id	sid	tid	token	lemma	pos
cord-016293-pyb00pt5	1	1	key	key	NNP
cord-016293-pyb00pt5	1	2	:	:	:
cord-016293-pyb00pt5	1	3	cord-016293-pyb00pt5	cord-016293-pyb00pt5	JJ
cord-016293-pyb00pt5	1	4	authors	author	NNS
cord-016293-pyb00pt5	1	5	:	:	:
cord-016293-pyb00pt5	1	6	Newell	Newell	NNP
cord-016293-pyb00pt5	1	7	-	-	HYPH
cord-016293-pyb00pt5	1	8	McGloughlin	McGloughlin	NNP
cord-016293-pyb00pt5	1	9	,	,	,
cord-016293-pyb00pt5	1	10	Martina	Martina	NNP
cord-016293-pyb00pt5	1	11	;	;	:
cord-016293-pyb00pt5	2	1	Re	re	UH
cord-016293-pyb00pt5	2	2	,	,	,
cord-016293-pyb00pt5	2	3	Edward	Edward	NNP
cord-016293-pyb00pt5	2	4	title	title	NN
cord-016293-pyb00pt5	2	5	:	:	:
cord-016293-pyb00pt5	2	6	The	the	DT
cord-016293-pyb00pt5	2	7	flowering	flowering	NN
cord-016293-pyb00pt5	2	8	of	of	IN
cord-016293-pyb00pt5	2	9	the	the	DT
cord-016293-pyb00pt5	2	10	age	age	NN
cord-016293-pyb00pt5	2	11	of	of	IN
cord-016293-pyb00pt5	2	12	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	2	13	1990–2000	1990–2000	CD
cord-016293-pyb00pt5	2	14	date	date	NN
cord-016293-pyb00pt5	2	15	:	:	:
cord-016293-pyb00pt5	3	1	2006	2006	CD
cord-016293-pyb00pt5	3	2	journal	journal	NNP
cord-016293-pyb00pt5	3	3	:	:	:
cord-016293-pyb00pt5	4	1	The	the	DT
cord-016293-pyb00pt5	4	2	Evolution	Evolution	NNP
cord-016293-pyb00pt5	4	3	of	of	IN
cord-016293-pyb00pt5	4	4	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	4	5	DOI	DOI	NNP
cord-016293-pyb00pt5	4	6	:	:	:
cord-016293-pyb00pt5	4	7	10.1007/1	10.1007/1	CD
cord-016293-pyb00pt5	4	8	-	-	HYPH
cord-016293-pyb00pt5	4	9	4020	4020	CD
cord-016293-pyb00pt5	4	10	-	-	HYPH
cord-016293-pyb00pt5	4	11	5149	5149	CD
cord-016293-pyb00pt5	4	12	-	-	SYM
cord-016293-pyb00pt5	4	13	2_4	2_4	CD
cord-016293-pyb00pt5	5	1	sha	sha	NNP
cord-016293-pyb00pt5	5	2	:	:	:
cord-016293-pyb00pt5	5	3	a7c4e3c86bfc3e71f49020102a6b260d20aeda5b	a7c4e3c86bfc3e71f49020102a6b260d20aeda5b	NNP
cord-016293-pyb00pt5	5	4	doc_id	doc_id	CD
cord-016293-pyb00pt5	5	5	:	:	:
cord-016293-pyb00pt5	5	6	16293	16293	CD
cord-016293-pyb00pt5	5	7	cord_uid	cord_uid	NNS
cord-016293-pyb00pt5	5	8	:	:	:
cord-016293-pyb00pt5	5	9	pyb00pt5	pyb00pt5	NNP
cord-016293-pyb00pt5	5	10	nan	nan	NNP
cord-016293-pyb00pt5	6	1	the	the	DT
cord-016293-pyb00pt5	6	2	significance	significance	NN
cord-016293-pyb00pt5	6	3	of	of	IN
cord-016293-pyb00pt5	6	4	developing	develop	VBG
cord-016293-pyb00pt5	6	5	genetic	genetic	JJ
cord-016293-pyb00pt5	6	6	and	and	CC
cord-016293-pyb00pt5	6	7	physical	physical	JJ
cord-016293-pyb00pt5	6	8	maps	map	NNS
cord-016293-pyb00pt5	6	9	of	of	IN
cord-016293-pyb00pt5	6	10	the	the	DT
cord-016293-pyb00pt5	6	11	genome	genome	NN
cord-016293-pyb00pt5	6	12	,	,	,
cord-016293-pyb00pt5	6	13	and	and	CC
cord-016293-pyb00pt5	6	14	the	the	DT
cord-016293-pyb00pt5	6	15	importance	importance	NN
cord-016293-pyb00pt5	6	16	of	of	IN
cord-016293-pyb00pt5	6	17	comparing	compare	VBG
cord-016293-pyb00pt5	6	18	the	the	DT
cord-016293-pyb00pt5	6	19	human	human	JJ
cord-016293-pyb00pt5	6	20	genome	genome	NN
cord-016293-pyb00pt5	6	21	with	with	IN
cord-016293-pyb00pt5	6	22	those	those	DT
cord-016293-pyb00pt5	6	23	of	of	IN
cord-016293-pyb00pt5	6	24	other	other	JJ
cord-016293-pyb00pt5	6	25	species	specie	NNS
cord-016293-pyb00pt5	6	26	.	.	.
cord-016293-pyb00pt5	7	1	It	-PRON-	PRP
cord-016293-pyb00pt5	7	2	also	also	RB
cord-016293-pyb00pt5	7	3	suggested	suggest	VBD
cord-016293-pyb00pt5	7	4	a	a	DT
cord-016293-pyb00pt5	7	5	preliminary	preliminary	JJ
cord-016293-pyb00pt5	7	6	focus	focus	NN
cord-016293-pyb00pt5	7	7	on	on	IN
cord-016293-pyb00pt5	7	8	improving	improve	VBG
cord-016293-pyb00pt5	7	9	current	current	JJ
cord-016293-pyb00pt5	7	10	technology	technology	NN
cord-016293-pyb00pt5	7	11	.	.	.
cord-016293-pyb00pt5	8	1	At	at	IN
cord-016293-pyb00pt5	8	2	the	the	DT
cord-016293-pyb00pt5	8	3	request	request	NN
cord-016293-pyb00pt5	8	4	of	of	IN
cord-016293-pyb00pt5	8	5	the	the	DT
cord-016293-pyb00pt5	8	6	U.S.	U.S.	NNP
cord-016293-pyb00pt5	8	7	Congress	Congress	NNP
cord-016293-pyb00pt5	8	8	,	,	,
cord-016293-pyb00pt5	8	9	the	the	DT
cord-016293-pyb00pt5	8	10	Office	Office	NNP
cord-016293-pyb00pt5	8	11	of	of	IN
cord-016293-pyb00pt5	8	12	Technology	Technology	NNP
cord-016293-pyb00pt5	8	13	Assessment	Assessment	NNP
cord-016293-pyb00pt5	8	14	(	(	-LRB-
cord-016293-pyb00pt5	8	15	OTA	OTA	NNP
cord-016293-pyb00pt5	8	16	)	)	-RRB-
cord-016293-pyb00pt5	8	17	also	also	RB
cord-016293-pyb00pt5	8	18	studied	study	VBD
cord-016293-pyb00pt5	8	19	the	the	DT
cord-016293-pyb00pt5	8	20	issue	issue	NN
cord-016293-pyb00pt5	8	21	,	,	,
cord-016293-pyb00pt5	8	22	and	and	CC
cord-016293-pyb00pt5	8	23	issued	issue	VBD
cord-016293-pyb00pt5	8	24	a	a	DT
cord-016293-pyb00pt5	8	25	document	document	NN
cord-016293-pyb00pt5	8	26	in	in	IN
cord-016293-pyb00pt5	8	27	1987	1987	CD
cord-016293-pyb00pt5	8	28	-within	-within	JJ
cord-016293-pyb00pt5	8	29	days	day	NNS
cord-016293-pyb00pt5	8	30	of	of	IN
cord-016293-pyb00pt5	8	31	the	the	DT
cord-016293-pyb00pt5	8	32	NRC	NRC	NNP
cord-016293-pyb00pt5	8	33	report	report	NN
cord-016293-pyb00pt5	8	34	-that	-that	WDT
cord-016293-pyb00pt5	8	35	was	be	VBD
cord-016293-pyb00pt5	8	36	similarly	similarly	RB
cord-016293-pyb00pt5	8	37	supportive	supportive	JJ
cord-016293-pyb00pt5	8	38	.	.	.
cord-016293-pyb00pt5	9	1	The	the	DT
cord-016293-pyb00pt5	9	2	OTA	OTA	NNP
cord-016293-pyb00pt5	9	3	report	report	NN
cord-016293-pyb00pt5	9	4	discussed	discuss	VBD
cord-016293-pyb00pt5	9	5	,	,	,
cord-016293-pyb00pt5	9	6	in	in	IN
cord-016293-pyb00pt5	9	7	addition	addition	NN
cord-016293-pyb00pt5	9	8	to	to	IN
cord-016293-pyb00pt5	9	9	scientific	scientific	JJ
cord-016293-pyb00pt5	9	10	issues	issue	NNS
cord-016293-pyb00pt5	9	11	,	,	,
cord-016293-pyb00pt5	9	12	social	social	JJ
cord-016293-pyb00pt5	9	13	and	and	CC
cord-016293-pyb00pt5	9	14	ethical	ethical	JJ
cord-016293-pyb00pt5	9	15	implications	implication	NNS
cord-016293-pyb00pt5	9	16	of	of	IN
cord-016293-pyb00pt5	9	17	a	a	DT
cord-016293-pyb00pt5	9	18	genome	genome	NN
cord-016293-pyb00pt5	9	19	program	program	NN
cord-016293-pyb00pt5	9	20	together	together	RB
cord-016293-pyb00pt5	9	21	with	with	IN
cord-016293-pyb00pt5	9	22	problems	problem	NNS
cord-016293-pyb00pt5	9	23	of	of	IN
cord-016293-pyb00pt5	9	24	managing	manage	VBG
cord-016293-pyb00pt5	9	25	funding	funding	NN
cord-016293-pyb00pt5	9	26	,	,	,
cord-016293-pyb00pt5	9	27	negotiating	negotiate	VBG
cord-016293-pyb00pt5	9	28	policy	policy	NN
cord-016293-pyb00pt5	9	29	and	and	CC
cord-016293-pyb00pt5	9	30	coordinating	coordinate	VBG
cord-016293-pyb00pt5	9	31	research	research	NN
cord-016293-pyb00pt5	9	32	efforts	effort	NNS
cord-016293-pyb00pt5	9	33	.	.	.
cord-016293-pyb00pt5	10	1	Prompted	prompt	VBN
cord-016293-pyb00pt5	10	2	by	by	IN
cord-016293-pyb00pt5	10	3	advisers	adviser	NNS
cord-016293-pyb00pt5	10	4	at	at	IN
cord-016293-pyb00pt5	10	5	a	a	DT
cord-016293-pyb00pt5	10	6	1988	1988	CD
cord-016293-pyb00pt5	10	7	meeting	meeting	NN
cord-016293-pyb00pt5	10	8	in	in	IN
cord-016293-pyb00pt5	10	9	Reston	Reston	NNP
cord-016293-pyb00pt5	10	10	,	,	,
cord-016293-pyb00pt5	10	11	Virginia	Virginia	NNP
cord-016293-pyb00pt5	10	12	,	,	,
cord-016293-pyb00pt5	10	13	James	James	NNP
cord-016293-pyb00pt5	10	14	Wyngaarden	Wyngaarden	NNP
cord-016293-pyb00pt5	10	15	,	,	,
cord-016293-pyb00pt5	10	16	then	then	RB
cord-016293-pyb00pt5	10	17	director	director	NN
cord-016293-pyb00pt5	10	18	of	of	IN
cord-016293-pyb00pt5	10	19	the	the	DT
cord-016293-pyb00pt5	10	20	National	National	NNP
cord-016293-pyb00pt5	10	21	Institutes	Institutes	NNPS
cord-016293-pyb00pt5	10	22	of	of	IN
cord-016293-pyb00pt5	10	23	Health	Health	NNP
cord-016293-pyb00pt5	10	24	(	(	-LRB-
cord-016293-pyb00pt5	10	25	NIH	NIH	NNP
cord-016293-pyb00pt5	10	26	)	)	-RRB-
cord-016293-pyb00pt5	10	27	,	,	,
cord-016293-pyb00pt5	10	28	decided	decide	VBD
cord-016293-pyb00pt5	10	29	that	that	IN
cord-016293-pyb00pt5	10	30	the	the	DT
cord-016293-pyb00pt5	10	31	agency	agency	NN
cord-016293-pyb00pt5	10	32	should	should	MD
cord-016293-pyb00pt5	10	33	be	be	VB
cord-016293-pyb00pt5	10	34	a	a	DT
cord-016293-pyb00pt5	10	35	major	major	JJ
cord-016293-pyb00pt5	10	36	player	player	NN
cord-016293-pyb00pt5	10	37	in	in	IN
cord-016293-pyb00pt5	10	38	the	the	DT
cord-016293-pyb00pt5	10	39	HGP	HGP	NNP
cord-016293-pyb00pt5	10	40	,	,	,
cord-016293-pyb00pt5	10	41	effectively	effectively	RB
cord-016293-pyb00pt5	10	42	seizing	seize	VBG
cord-016293-pyb00pt5	10	43	the	the	DT
cord-016293-pyb00pt5	10	44	lead	lead	NN
cord-016293-pyb00pt5	10	45	from	from	IN
cord-016293-pyb00pt5	10	46	DOE	DOE	NNP
cord-016293-pyb00pt5	10	47	.	.	.
cord-016293-pyb00pt5	11	1	The	the	DT
cord-016293-pyb00pt5	11	2	start	start	NN
cord-016293-pyb00pt5	11	3	of	of	IN
cord-016293-pyb00pt5	11	4	the	the	DT
cord-016293-pyb00pt5	11	5	joint	joint	JJ
cord-016293-pyb00pt5	11	6	effort	effort	NN
cord-016293-pyb00pt5	11	7	was	be	VBD
cord-016293-pyb00pt5	11	8	in	in	IN
cord-016293-pyb00pt5	11	9	May	May	NNP
cord-016293-pyb00pt5	11	10	1990	1990	CD
cord-016293-pyb00pt5	11	11	(	(	-LRB-
cord-016293-pyb00pt5	11	12	with	with	IN
cord-016293-pyb00pt5	11	13	an	an	DT
cord-016293-pyb00pt5	11	14	"	"	``
cord-016293-pyb00pt5	11	15	official	official	JJ
cord-016293-pyb00pt5	11	16	"	"	''
cord-016293-pyb00pt5	11	17	start	start	NN
cord-016293-pyb00pt5	11	18	in	in	IN
cord-016293-pyb00pt5	11	19	October	October	NNP
cord-016293-pyb00pt5	11	20	)	)	-RRB-
cord-016293-pyb00pt5	11	21	when	when	WRB
cord-016293-pyb00pt5	11	22	a	a	DT
cord-016293-pyb00pt5	11	23	5-year	5-year	CD
cord-016293-pyb00pt5	11	24	plan	plan	NN
cord-016293-pyb00pt5	11	25	detailing	detail	VBG
cord-016293-pyb00pt5	11	26	the	the	DT
cord-016293-pyb00pt5	11	27	goals	goal	NNS
cord-016293-pyb00pt5	11	28	of	of	IN
cord-016293-pyb00pt5	11	29	the	the	DT
cord-016293-pyb00pt5	11	30	U.S.	U.S.	NNP
cord-016293-pyb00pt5	11	31	Human	Human	NNP
cord-016293-pyb00pt5	11	32	Genome	Genome	NNP
cord-016293-pyb00pt5	11	33	Project	Project	NNP
cord-016293-pyb00pt5	11	34	was	be	VBD
cord-016293-pyb00pt5	11	35	presented	present	VBN
cord-016293-pyb00pt5	11	36	to	to	IN
cord-016293-pyb00pt5	11	37	members	member	NNS
cord-016293-pyb00pt5	11	38	of	of	IN
cord-016293-pyb00pt5	11	39	congressional	congressional	JJ
cord-016293-pyb00pt5	11	40	appropriations	appropriation	NNS
cord-016293-pyb00pt5	11	41	committees	committee	NNS
cord-016293-pyb00pt5	11	42	in	in	IN
cord-016293-pyb00pt5	11	43	mid	mid	NNP
cord-016293-pyb00pt5	11	44	-	-	NNP
cord-016293-pyb00pt5	11	45	February	February	NNP
cord-016293-pyb00pt5	11	46	.	.	.
cord-016293-pyb00pt5	12	1	This	this	DT
cord-016293-pyb00pt5	12	2	document	document	NN
cord-016293-pyb00pt5	12	3	co	co	VBD
cord-016293-pyb00pt5	12	4	-	-	VBN
cord-016293-pyb00pt5	12	5	authored	author	VBN
cord-016293-pyb00pt5	12	6	by	by	IN
cord-016293-pyb00pt5	12	7	DOE	DOE	NNP
cord-016293-pyb00pt5	12	8	and	and	CC
cord-016293-pyb00pt5	12	9	NIH	NIH	NNP
cord-016293-pyb00pt5	12	10	and	and	CC
cord-016293-pyb00pt5	12	11	titled	title	VBD
cord-016293-pyb00pt5	12	12	"	"	``
cord-016293-pyb00pt5	12	13	Understanding	understand	VBG
cord-016293-pyb00pt5	12	14	Our	-PRON-	PRP$
cord-016293-pyb00pt5	12	15	Genetic	genetic	JJ
cord-016293-pyb00pt5	12	16	Inheritance	Inheritance	NNP
cord-016293-pyb00pt5	12	17	,	,	,
cord-016293-pyb00pt5	12	18	the	the	DT
cord-016293-pyb00pt5	12	19	U.S.	U.S.	NNP
cord-016293-pyb00pt5	12	20	Human	Human	NNP
cord-016293-pyb00pt5	12	21	Genome	Genome	NNP
cord-016293-pyb00pt5	12	22	Project	Project	NNP
cord-016293-pyb00pt5	12	23	:	:	:
cord-016293-pyb00pt5	12	24	The	the	DT
cord-016293-pyb00pt5	12	25	First	First	NNP
cord-016293-pyb00pt5	12	26	Five	Five	NNP
cord-016293-pyb00pt5	12	27	Years	Years	NNPS
cord-016293-pyb00pt5	12	28	"	"	''
cord-016293-pyb00pt5	12	29	examined	examine	VBD
cord-016293-pyb00pt5	12	30	the	the	DT
cord-016293-pyb00pt5	12	31	then	then	RB
cord-016293-pyb00pt5	12	32	current	current	JJ
cord-016293-pyb00pt5	12	33	state	state	NN
cord-016293-pyb00pt5	12	34	of	of	IN
cord-016293-pyb00pt5	12	35	genome	genome	NN
cord-016293-pyb00pt5	12	36	science	science	NN
cord-016293-pyb00pt5	12	37	.	.	.
cord-016293-pyb00pt5	13	1	The	the	DT
cord-016293-pyb00pt5	13	2	plan	plan	NN
cord-016293-pyb00pt5	13	3	also	also	RB
cord-016293-pyb00pt5	13	4	set	set	VBD
cord-016293-pyb00pt5	13	5	forth	forth	RP
cord-016293-pyb00pt5	13	6	complementary	complementary	JJ
cord-016293-pyb00pt5	13	7	approaches	approach	NNS
cord-016293-pyb00pt5	13	8	of	of	IN
cord-016293-pyb00pt5	13	9	the	the	DT
cord-016293-pyb00pt5	13	10	two	two	CD
cord-016293-pyb00pt5	13	11	agencies	agency	NNS
cord-016293-pyb00pt5	13	12	for	for	IN
cord-016293-pyb00pt5	13	13	attaining	attain	VBG
cord-016293-pyb00pt5	13	14	scientific	scientific	JJ
cord-016293-pyb00pt5	13	15	goals	goal	NNS
cord-016293-pyb00pt5	13	16	and	and	CC
cord-016293-pyb00pt5	13	17	presented	present	VBD
cord-016293-pyb00pt5	13	18	plans	plan	NNS
cord-016293-pyb00pt5	13	19	for	for	IN
cord-016293-pyb00pt5	13	20	administering	administer	VBG
cord-016293-pyb00pt5	13	21	research	research	NN
cord-016293-pyb00pt5	13	22	agenda	agenda	NN
cord-016293-pyb00pt5	13	23	;	;	:
cord-016293-pyb00pt5	13	24	it	-PRON-	PRP
cord-016293-pyb00pt5	13	25	described	describe	VBD
cord-016293-pyb00pt5	13	26	collaboration	collaboration	NN
cord-016293-pyb00pt5	13	27	between	between	IN
cord-016293-pyb00pt5	13	28	U.S.	U.S.	NNP
cord-016293-pyb00pt5	13	29	and	and	CC
cord-016293-pyb00pt5	13	30	international	international	JJ
cord-016293-pyb00pt5	13	31	agencies	agency	NNS
cord-016293-pyb00pt5	13	32	and	and	CC
cord-016293-pyb00pt5	13	33	presented	present	VBD
cord-016293-pyb00pt5	13	34	budget	budget	NN
cord-016293-pyb00pt5	13	35	projections	projection	NNS
cord-016293-pyb00pt5	13	36	for	for	IN
cord-016293-pyb00pt5	13	37	the	the	DT
cord-016293-pyb00pt5	13	38	project	project	NN
cord-016293-pyb00pt5	13	39	.	.	.
cord-016293-pyb00pt5	14	1	According	accord	VBG
cord-016293-pyb00pt5	14	2	to	to	IN
cord-016293-pyb00pt5	14	3	the	the	DT
cord-016293-pyb00pt5	14	4	document	document	NN
cord-016293-pyb00pt5	14	5	,	,	,
cord-016293-pyb00pt5	14	6	"	"	''
cord-016293-pyb00pt5	14	7	a	a	DT
cord-016293-pyb00pt5	14	8	centrally	centrally	RB
cord-016293-pyb00pt5	14	9	coordinated	coordinate	VBN
cord-016293-pyb00pt5	14	10	project	project	NN
cord-016293-pyb00pt5	14	11	,	,	,
cord-016293-pyb00pt5	14	12	focused	focus	VBN
cord-016293-pyb00pt5	14	13	on	on	IN
cord-016293-pyb00pt5	14	14	specific	specific	JJ
cord-016293-pyb00pt5	14	15	objectives	objective	NNS
cord-016293-pyb00pt5	14	16	,	,	,
cord-016293-pyb00pt5	14	17	is	be	VBZ
cord-016293-pyb00pt5	14	18	believed	believe	VBN
cord-016293-pyb00pt5	14	19	to	to	TO
cord-016293-pyb00pt5	14	20	be	be	VB
cord-016293-pyb00pt5	14	21	the	the	DT
cord-016293-pyb00pt5	14	22	most	most	RBS
cord-016293-pyb00pt5	14	23	efficient	efficient	JJ
cord-016293-pyb00pt5	14	24	and	and	CC
cord-016293-pyb00pt5	14	25	least	least	JJS
cord-016293-pyb00pt5	14	26	expensive	expensive	JJ
cord-016293-pyb00pt5	14	27	way	way	NN
cord-016293-pyb00pt5	14	28	"	"	''
cord-016293-pyb00pt5	14	29	to	to	TO
cord-016293-pyb00pt5	14	30	obtain	obtain	VB
cord-016293-pyb00pt5	14	31	the	the	DT
cord-016293-pyb00pt5	14	32	3-billion	3-billion	CD
cord-016293-pyb00pt5	14	33	base	base	NN
cord-016293-pyb00pt5	14	34	pair	pair	NN
cord-016293-pyb00pt5	14	35	map	map	NN
cord-016293-pyb00pt5	14	36	of	of	IN
cord-016293-pyb00pt5	14	37	the	the	DT
cord-016293-pyb00pt5	14	38	human	human	JJ
cord-016293-pyb00pt5	14	39	genome	genome	NN
cord-016293-pyb00pt5	14	40	.	.	.
cord-016293-pyb00pt5	15	1	In	in	IN
cord-016293-pyb00pt5	15	2	the	the	DT
cord-016293-pyb00pt5	15	3	course	course	NN
cord-016293-pyb00pt5	15	4	of	of	IN
cord-016293-pyb00pt5	15	5	the	the	DT
cord-016293-pyb00pt5	15	6	project	project	NN
cord-016293-pyb00pt5	15	7	,	,	,
cord-016293-pyb00pt5	15	8	especially	especially	RB
cord-016293-pyb00pt5	15	9	in	in	IN
cord-016293-pyb00pt5	15	10	the	the	DT
cord-016293-pyb00pt5	15	11	early	early	JJ
cord-016293-pyb00pt5	15	12	years	year	NNS
cord-016293-pyb00pt5	15	13	,	,	,
cord-016293-pyb00pt5	15	14	the	the	DT
cord-016293-pyb00pt5	15	15	plan	plan	NN
cord-016293-pyb00pt5	15	16	stated	state	VBD
cord-016293-pyb00pt5	15	17	that	that	IN
cord-016293-pyb00pt5	15	18	"	"	``
cord-016293-pyb00pt5	15	19	much	much	JJ
cord-016293-pyb00pt5	15	20	new	new	JJ
cord-016293-pyb00pt5	15	21	technology	technology	NN
cord-016293-pyb00pt5	15	22	will	will	MD
cord-016293-pyb00pt5	15	23	be	be	VB
cord-016293-pyb00pt5	15	24	developed	develop	VBN
cord-016293-pyb00pt5	15	25	that	that	WDT
cord-016293-pyb00pt5	15	26	will	will	MD
cord-016293-pyb00pt5	15	27	facilitate	facilitate	VB
cord-016293-pyb00pt5	15	28	biomedical	biomedical	JJ
cord-016293-pyb00pt5	15	29	and	and	CC
cord-016293-pyb00pt5	15	30	a	a	DT
cord-016293-pyb00pt5	15	31	broad	broad	JJ
cord-016293-pyb00pt5	15	32	range	range	NN
cord-016293-pyb00pt5	15	33	of	of	IN
cord-016293-pyb00pt5	15	34	biological	biological	JJ
cord-016293-pyb00pt5	15	35	research	research	NN
cord-016293-pyb00pt5	15	36	,	,	,
cord-016293-pyb00pt5	15	37	bring	bring	VB
cord-016293-pyb00pt5	15	38	down	down	RP
cord-016293-pyb00pt5	15	39	the	the	DT
cord-016293-pyb00pt5	15	40	cost	cost	NN
cord-016293-pyb00pt5	15	41	of	of	IN
cord-016293-pyb00pt5	15	42	many	many	JJ
cord-016293-pyb00pt5	15	43	experiments	experiment	NNS
cord-016293-pyb00pt5	15	44	(	(	-LRB-
cord-016293-pyb00pt5	15	45	mapping	mapping	NN
cord-016293-pyb00pt5	15	46	and	and	CC
cord-016293-pyb00pt5	15	47	sequencing	sequencing	NN
cord-016293-pyb00pt5	15	48	)	)	-RRB-
cord-016293-pyb00pt5	15	49	,	,	,
cord-016293-pyb00pt5	15	50	and	and	CC
cord-016293-pyb00pt5	15	51	finding	find	VBG
cord-016293-pyb00pt5	15	52	applications	application	NNS
cord-016293-pyb00pt5	15	53	in	in	IN
cord-016293-pyb00pt5	15	54	numerous	numerous	JJ
cord-016293-pyb00pt5	15	55	other	other	JJ
cord-016293-pyb00pt5	15	56	fields	field	NNS
cord-016293-pyb00pt5	15	57	.	.	.
cord-016293-pyb00pt5	16	1	"	"	''
cord-016293-pyb00pt5	17	1	The	the	DT
cord-016293-pyb00pt5	17	2	plan	plan	NN
cord-016293-pyb00pt5	17	3	built	build	VBN
cord-016293-pyb00pt5	17	4	upon	upon	IN
cord-016293-pyb00pt5	17	5	the	the	DT
cord-016293-pyb00pt5	17	6	1988	1988	CD
cord-016293-pyb00pt5	17	7	reports	report	NNS
cord-016293-pyb00pt5	17	8	of	of	IN
cord-016293-pyb00pt5	17	9	the	the	DT
cord-016293-pyb00pt5	17	10	Office	Office	NNP
cord-016293-pyb00pt5	17	11	of	of	IN
cord-016293-pyb00pt5	17	12	Technology	Technology	NNP
cord-016293-pyb00pt5	17	13	Assessment	Assessment	NNP
cord-016293-pyb00pt5	17	14	and	and	CC
cord-016293-pyb00pt5	17	15	the	the	DT
cord-016293-pyb00pt5	17	16	National	National	NNP
cord-016293-pyb00pt5	17	17	Research	Research	NNP
cord-016293-pyb00pt5	17	18	Council	Council	NNP
cord-016293-pyb00pt5	17	19	on	on	IN
cord-016293-pyb00pt5	17	20	mapping	mapping	NN
cord-016293-pyb00pt5	17	21	and	and	CC
cord-016293-pyb00pt5	17	22	sequencing	sequence	VBG
cord-016293-pyb00pt5	17	23	the	the	DT
cord-016293-pyb00pt5	17	24	human	human	JJ
cord-016293-pyb00pt5	17	25	genome	genome	NN
cord-016293-pyb00pt5	17	26	.	.	.
cord-016293-pyb00pt5	18	1	"	"	''
cord-016293-pyb00pt5	19	1	In	in	IN
cord-016293-pyb00pt5	19	2	the	the	DT
cord-016293-pyb00pt5	19	3	intervening	intervene	VBG
cord-016293-pyb00pt5	19	4	two	two	CD
cord-016293-pyb00pt5	19	5	years	year	NNS
cord-016293-pyb00pt5	19	6	,	,	,
cord-016293-pyb00pt5	19	7	"	"	''
cord-016293-pyb00pt5	19	8	the	the	DT
cord-016293-pyb00pt5	19	9	document	document	NN
cord-016293-pyb00pt5	19	10	said	say	VBD
cord-016293-pyb00pt5	19	11	,	,	,
cord-016293-pyb00pt5	19	12	"	"	``
cord-016293-pyb00pt5	19	13	improvements	improvement	NNS
cord-016293-pyb00pt5	19	14	in	in	IN
cord-016293-pyb00pt5	19	15	technology	technology	NN
cord-016293-pyb00pt5	19	16	for	for	IN
cord-016293-pyb00pt5	19	17	almost	almost	RB
cord-016293-pyb00pt5	19	18	every	every	DT
cord-016293-pyb00pt5	19	19	aspect	aspect	NN
cord-016293-pyb00pt5	19	20	of	of	IN
cord-016293-pyb00pt5	19	21	genomics	genomic	NNS
cord-016293-pyb00pt5	19	22	research	research	NN
cord-016293-pyb00pt5	19	23	have	have	VBP
cord-016293-pyb00pt5	19	24	taken	take	VBN
cord-016293-pyb00pt5	19	25	place	place	NN
cord-016293-pyb00pt5	19	26	.	.	.
cord-016293-pyb00pt5	20	1	As	as	IN
cord-016293-pyb00pt5	20	2	a	a	DT
cord-016293-pyb00pt5	20	3	result	result	NN
cord-016293-pyb00pt5	20	4	,	,	,
cord-016293-pyb00pt5	20	5	more	more	RBR
cord-016293-pyb00pt5	20	6	specific	specific	JJ
cord-016293-pyb00pt5	20	7	goals	goal	NNS
cord-016293-pyb00pt5	20	8	can	can	MD
cord-016293-pyb00pt5	20	9	now	now	RB
cord-016293-pyb00pt5	20	10	be	be	VB
cord-016293-pyb00pt5	20	11	set	set	VBN
cord-016293-pyb00pt5	20	12	for	for	IN
cord-016293-pyb00pt5	20	13	the	the	DT
cord-016293-pyb00pt5	20	14	project	project	NN
cord-016293-pyb00pt5	20	15	.	.	.
cord-016293-pyb00pt5	21	1	"	"	''
cord-016293-pyb00pt5	22	1	The	the	DT
cord-016293-pyb00pt5	22	2	document	document	NN
cord-016293-pyb00pt5	22	3	describes	describe	VBZ
cord-016293-pyb00pt5	22	4	objectives	objective	NNS
cord-016293-pyb00pt5	22	5	in	in	IN
cord-016293-pyb00pt5	22	6	the	the	DT
cord-016293-pyb00pt5	22	7	following	follow	VBG
cord-016293-pyb00pt5	22	8	areas	area	NNS
cord-016293-pyb00pt5	22	9	mapping	mapping	NN
cord-016293-pyb00pt5	22	10	and	and	CC
cord-016293-pyb00pt5	22	11	sequencing	sequence	VBG
cord-016293-pyb00pt5	22	12	the	the	DT
cord-016293-pyb00pt5	22	13	human	human	JJ
cord-016293-pyb00pt5	22	14	genome	genome	NN
cord-016293-pyb00pt5	22	15	and	and	CC
cord-016293-pyb00pt5	22	16	the	the	DT
cord-016293-pyb00pt5	22	17	genomes	genome	NNS
cord-016293-pyb00pt5	22	18	of	of	IN
cord-016293-pyb00pt5	22	19	model	model	NN
cord-016293-pyb00pt5	22	20	organisms	organism	NNS
cord-016293-pyb00pt5	22	21	;	;	:
cord-016293-pyb00pt5	22	22	data	datum	NNS
cord-016293-pyb00pt5	22	23	collection	collection	NN
cord-016293-pyb00pt5	22	24	and	and	CC
cord-016293-pyb00pt5	22	25	distribution	distribution	NN
cord-016293-pyb00pt5	22	26	;	;	,
cord-016293-pyb00pt5	22	27	ethical	ethical	JJ
cord-016293-pyb00pt5	22	28	,	,	,
cord-016293-pyb00pt5	22	29	legal	legal	JJ
cord-016293-pyb00pt5	22	30	,	,	,
cord-016293-pyb00pt5	22	31	and	and	CC
cord-016293-pyb00pt5	22	32	social	social	JJ
cord-016293-pyb00pt5	22	33	considerations	consideration	NNS
cord-016293-pyb00pt5	22	34	;	;	:
cord-016293-pyb00pt5	22	35	research	research	NN
cord-016293-pyb00pt5	22	36	training	training	NN
cord-016293-pyb00pt5	22	37	;	;	:
cord-016293-pyb00pt5	22	38	technology	technology	NN
cord-016293-pyb00pt5	22	39	development	development	NN
cord-016293-pyb00pt5	22	40	;	;	:
cord-016293-pyb00pt5	22	41	and	and	CC
cord-016293-pyb00pt5	22	42	technology	technology	NN
cord-016293-pyb00pt5	22	43	transfer	transfer	NN
cord-016293-pyb00pt5	22	44	.	.	.
cord-016293-pyb00pt5	23	1	These	these	DT
cord-016293-pyb00pt5	23	2	goals	goal	NNS
cord-016293-pyb00pt5	23	3	were	be	VBD
cord-016293-pyb00pt5	23	4	to	to	TO
cord-016293-pyb00pt5	23	5	be	be	VB
cord-016293-pyb00pt5	23	6	reviewed	review	VBN
cord-016293-pyb00pt5	23	7	each	each	DT
cord-016293-pyb00pt5	23	8	year	year	NN
cord-016293-pyb00pt5	23	9	and	and	CC
cord-016293-pyb00pt5	23	10	updated	update	VBD
cord-016293-pyb00pt5	23	11	as	as	IN
cord-016293-pyb00pt5	23	12	further	further	JJ
cord-016293-pyb00pt5	23	13	advances	advance	NNS
cord-016293-pyb00pt5	23	14	occured	occur	VBD
cord-016293-pyb00pt5	23	15	in	in	IN
cord-016293-pyb00pt5	23	16	the	the	DT
cord-016293-pyb00pt5	23	17	underlying	underlie	VBG
cord-016293-pyb00pt5	23	18	technologies	technology	NNS
cord-016293-pyb00pt5	23	19	.	.	.
cord-016293-pyb00pt5	24	1	They	-PRON-	PRP
cord-016293-pyb00pt5	24	2	identified	identify	VBD
cord-016293-pyb00pt5	24	3	the	the	DT
cord-016293-pyb00pt5	24	4	overall	overall	JJ
cord-016293-pyb00pt5	24	5	budget	budget	NN
cord-016293-pyb00pt5	24	6	needs	need	VBZ
cord-016293-pyb00pt5	24	7	to	to	TO
cord-016293-pyb00pt5	24	8	be	be	VB
cord-016293-pyb00pt5	24	9	the	the	DT
cord-016293-pyb00pt5	24	10	same	same	JJ
cord-016293-pyb00pt5	24	11	as	as	IN
cord-016293-pyb00pt5	24	12	those	those	DT
cord-016293-pyb00pt5	24	13	identified	identify	VBN
cord-016293-pyb00pt5	24	14	by	by	IN
cord-016293-pyb00pt5	24	15	OTA	OTA	NNP
cord-016293-pyb00pt5	24	16	and	and	CC
cord-016293-pyb00pt5	24	17	NRC	NRC	NNP
cord-016293-pyb00pt5	24	18	,	,	,
cord-016293-pyb00pt5	24	19	namely	namely	RB
cord-016293-pyb00pt5	24	20	about	about	RB
cord-016293-pyb00pt5	24	21	$	$	$
cord-016293-pyb00pt5	24	22	200	200	CD
cord-016293-pyb00pt5	24	23	million	million	CD
cord-016293-pyb00pt5	24	24	per	per	IN
cord-016293-pyb00pt5	24	25	year	year	NN
cord-016293-pyb00pt5	24	26	for	for	IN
cord-016293-pyb00pt5	24	27	approximately	approximately	RB
cord-016293-pyb00pt5	24	28	15	15	CD
cord-016293-pyb00pt5	24	29	years	year	NNS
cord-016293-pyb00pt5	24	30	.	.	.
cord-016293-pyb00pt5	25	1	This	this	DT
cord-016293-pyb00pt5	25	2	came	come	VBD
cord-016293-pyb00pt5	25	3	to	to	IN
cord-016293-pyb00pt5	25	4	$	$	$
cord-016293-pyb00pt5	25	5	13	13	CD
cord-016293-pyb00pt5	25	6	billion	billion	CD
cord-016293-pyb00pt5	25	7	over	over	IN
cord-016293-pyb00pt5	25	8	the	the	DT
cord-016293-pyb00pt5	25	9	entire	entire	JJ
cord-016293-pyb00pt5	25	10	period	period	NN
cord-016293-pyb00pt5	25	11	of	of	IN
cord-016293-pyb00pt5	25	12	the	the	DT
cord-016293-pyb00pt5	25	13	project	project	NN
cord-016293-pyb00pt5	25	14	.	.	.
cord-016293-pyb00pt5	26	1	Considering	consider	VBG
cord-016293-pyb00pt5	26	2	that	that	IN
cord-016293-pyb00pt5	26	3	in	in	IN
cord-016293-pyb00pt5	26	4	July	July	NNP
cord-016293-pyb00pt5	26	5	1990	1990	CD
cord-016293-pyb00pt5	26	6	,	,	,
cord-016293-pyb00pt5	26	7	the	the	DT
cord-016293-pyb00pt5	26	8	DNA	dna	NN
cord-016293-pyb00pt5	26	9	databases	database	NNS
cord-016293-pyb00pt5	26	10	contained	contain	VBN
cord-016293-pyb00pt5	26	11	only	only	RB
cord-016293-pyb00pt5	26	12	seven	seven	CD
cord-016293-pyb00pt5	26	13	sequences	sequence	NNS
cord-016293-pyb00pt5	26	14	greater	great	JJR
cord-016293-pyb00pt5	26	15	than	than	IN
cord-016293-pyb00pt5	26	16	0.1	0.1	CD
cord-016293-pyb00pt5	26	17	Mb	Mb	NNS
cord-016293-pyb00pt5	27	1	this	this	DT
cord-016293-pyb00pt5	27	2	was	be	VBD
cord-016293-pyb00pt5	27	3	a	a	DT
cord-016293-pyb00pt5	27	4	major	major	JJ
cord-016293-pyb00pt5	27	5	leap	leap	NN
cord-016293-pyb00pt5	27	6	of	of	IN
cord-016293-pyb00pt5	27	7	faith	faith	NN
cord-016293-pyb00pt5	27	8	.	.	.
cord-016293-pyb00pt5	28	1	This	this	DT
cord-016293-pyb00pt5	28	2	approach	approach	NN
cord-016293-pyb00pt5	28	3	was	be	VBD
cord-016293-pyb00pt5	28	4	a	a	DT
cord-016293-pyb00pt5	28	5	major	major	JJ
cord-016293-pyb00pt5	28	6	departure	departure	NN
cord-016293-pyb00pt5	28	7	from	from	IN
cord-016293-pyb00pt5	28	8	the	the	DT
cord-016293-pyb00pt5	28	9	single	single	JJ
cord-016293-pyb00pt5	28	10	-	-	HYPH
cord-016293-pyb00pt5	28	11	investigator	investigator	NN
cord-016293-pyb00pt5	28	12	-	-	HYPH
cord-016293-pyb00pt5	28	13	based	base	VBN
cord-016293-pyb00pt5	28	14	gene	gene	NN
cord-016293-pyb00pt5	28	15	of	of	IN
cord-016293-pyb00pt5	28	16	interest	interest	NN
cord-016293-pyb00pt5	28	17	focus	focus	NN
cord-016293-pyb00pt5	28	18	that	that	DT
cord-016293-pyb00pt5	28	19	research	research	NN
cord-016293-pyb00pt5	28	20	took	take	VBD
cord-016293-pyb00pt5	28	21	hitherto	hitherto	VBN
cord-016293-pyb00pt5	28	22	.	.	.
cord-016293-pyb00pt5	29	1	This	this	DT
cord-016293-pyb00pt5	29	2	sparked	spark	VBD
cord-016293-pyb00pt5	29	3	much	much	JJ
cord-016293-pyb00pt5	29	4	controversy	controversy	NN
cord-016293-pyb00pt5	29	5	both	both	CC
cord-016293-pyb00pt5	29	6	before	before	IN
cord-016293-pyb00pt5	29	7	and	and	CC
cord-016293-pyb00pt5	29	8	after	after	IN
cord-016293-pyb00pt5	29	9	its	-PRON-	PRP$
cord-016293-pyb00pt5	29	10	inception	inception	NN
cord-016293-pyb00pt5	29	11	.	.	.
cord-016293-pyb00pt5	30	1	Critics	critic	NNS
cord-016293-pyb00pt5	30	2	questioned	question	VBD
cord-016293-pyb00pt5	30	3	the	the	DT
cord-016293-pyb00pt5	30	4	usefulness	usefulness	NN
cord-016293-pyb00pt5	30	5	of	of	IN
cord-016293-pyb00pt5	30	6	genomic	genomic	JJ
cord-016293-pyb00pt5	30	7	sequencing	sequencing	NN
cord-016293-pyb00pt5	30	8	,	,	,
cord-016293-pyb00pt5	30	9	they	-PRON-	PRP
cord-016293-pyb00pt5	30	10	objected	object	VBD
cord-016293-pyb00pt5	30	11	to	to	IN
cord-016293-pyb00pt5	30	12	the	the	DT
cord-016293-pyb00pt5	30	13	high	high	JJ
cord-016293-pyb00pt5	30	14	cost	cost	NN
cord-016293-pyb00pt5	30	15	and	and	CC
cord-016293-pyb00pt5	30	16	suggested	suggest	VBD
cord-016293-pyb00pt5	30	17	it	-PRON-	PRP
cord-016293-pyb00pt5	30	18	might	may	MD
cord-016293-pyb00pt5	30	19	divert	divert	VB
cord-016293-pyb00pt5	30	20	funds	fund	NNS
cord-016293-pyb00pt5	30	21	from	from	IN
cord-016293-pyb00pt5	30	22	other	other	JJ
cord-016293-pyb00pt5	30	23	,	,	,
cord-016293-pyb00pt5	30	24	more	more	RBR
cord-016293-pyb00pt5	30	25	focused	focused	JJ
cord-016293-pyb00pt5	30	26	,	,	,
cord-016293-pyb00pt5	30	27	basic	basic	JJ
cord-016293-pyb00pt5	30	28	research	research	NN
cord-016293-pyb00pt5	30	29	.	.	.
cord-016293-pyb00pt5	31	1	The	the	DT
cord-016293-pyb00pt5	31	2	prime	prime	JJ
cord-016293-pyb00pt5	31	3	argument	argument	NN
cord-016293-pyb00pt5	31	4	to	to	TO
cord-016293-pyb00pt5	31	5	support	support	VB
cord-016293-pyb00pt5	31	6	the	the	DT
cord-016293-pyb00pt5	31	7	latter	latter	JJ
cord-016293-pyb00pt5	31	8	position	position	NN
cord-016293-pyb00pt5	31	9	is	be	VBZ
cord-016293-pyb00pt5	31	10	that	that	IN
cord-016293-pyb00pt5	31	11	there	there	EX
cord-016293-pyb00pt5	31	12	appeared	appear	VBD
cord-016293-pyb00pt5	31	13	to	to	TO
cord-016293-pyb00pt5	31	14	be	be	VB
cord-016293-pyb00pt5	31	15	are	be	VBP
cord-016293-pyb00pt5	31	16	far	far	RB
cord-016293-pyb00pt5	31	17	less	less	JJR
cord-016293-pyb00pt5	31	18	genes	gene	NNS
cord-016293-pyb00pt5	31	19	than	than	IN
cord-016293-pyb00pt5	31	20	accounted	account	VBN
cord-016293-pyb00pt5	31	21	for	for	IN
cord-016293-pyb00pt5	31	22	by	by	IN
cord-016293-pyb00pt5	31	23	the	the	DT
cord-016293-pyb00pt5	31	24	mass	mass	NN
cord-016293-pyb00pt5	31	25	of	of	IN
cord-016293-pyb00pt5	31	26	DNA	DNA	NNP
cord-016293-pyb00pt5	31	27	which	which	WDT
cord-016293-pyb00pt5	31	28	would	would	MD
cord-016293-pyb00pt5	31	29	suggest	suggest	VB
cord-016293-pyb00pt5	31	30	that	that	IN
cord-016293-pyb00pt5	31	31	the	the	DT
cord-016293-pyb00pt5	31	32	major	major	JJ
cord-016293-pyb00pt5	31	33	part	part	NN
cord-016293-pyb00pt5	31	34	of	of	IN
cord-016293-pyb00pt5	31	35	the	the	DT
cord-016293-pyb00pt5	31	36	sequencing	sequencing	NN
cord-016293-pyb00pt5	31	37	effort	effort	NN
cord-016293-pyb00pt5	31	38	would	would	MD
cord-016293-pyb00pt5	31	39	be	be	VB
cord-016293-pyb00pt5	31	40	of	of	IN
cord-016293-pyb00pt5	31	41	long	long	JJ
cord-016293-pyb00pt5	31	42	stretches	stretch	NNS
cord-016293-pyb00pt5	31	43	of	of	IN
cord-016293-pyb00pt5	31	44	base	base	NN
cord-016293-pyb00pt5	31	45	pairs	pair	NNS
cord-016293-pyb00pt5	31	46	with	with	IN
cord-016293-pyb00pt5	31	47	no	no	DT
cord-016293-pyb00pt5	31	48	known	know	VBN
cord-016293-pyb00pt5	31	49	function	function	NN
cord-016293-pyb00pt5	31	50	,	,	,
cord-016293-pyb00pt5	31	51	the	the	DT
cord-016293-pyb00pt5	31	52	so	so	RB
cord-016293-pyb00pt5	31	53	-	-	HYPH
cord-016293-pyb00pt5	31	54	called	call	VBN
cord-016293-pyb00pt5	31	55	"	"	``
cord-016293-pyb00pt5	31	56	junk	junk	NN
cord-016293-pyb00pt5	31	57	DNA	dna	NN
cord-016293-pyb00pt5	31	58	.	.	.
cord-016293-pyb00pt5	31	59	"	"	''
cord-016293-pyb00pt5	32	1	And	and	CC
cord-016293-pyb00pt5	32	2	that	that	DT
cord-016293-pyb00pt5	32	3	was	be	VBD
cord-016293-pyb00pt5	32	4	in	in	IN
cord-016293-pyb00pt5	32	5	the	the	DT
cord-016293-pyb00pt5	32	6	days	day	NNS
cord-016293-pyb00pt5	32	7	when	when	WRB
cord-016293-pyb00pt5	32	8	the	the	DT
cord-016293-pyb00pt5	32	9	number	number	NN
cord-016293-pyb00pt5	32	10	of	of	IN
cord-016293-pyb00pt5	32	11	genes	gene	NNS
cord-016293-pyb00pt5	32	12	was	be	VBD
cord-016293-pyb00pt5	32	13	presumed	presume	VBN
cord-016293-pyb00pt5	32	14	to	to	TO
cord-016293-pyb00pt5	32	15	be	be	VB
cord-016293-pyb00pt5	32	16	80	80	CD
cord-016293-pyb00pt5	32	17	-	-	SYM
cord-016293-pyb00pt5	32	18	100,000	100,000	CD
cord-016293-pyb00pt5	32	19	.	.	.
cord-016293-pyb00pt5	33	1	If	if	IN
cord-016293-pyb00pt5	33	2	,	,	,
cord-016293-pyb00pt5	33	3	at	at	IN
cord-016293-pyb00pt5	33	4	that	that	DT
cord-016293-pyb00pt5	33	5	stage	stage	NN
cord-016293-pyb00pt5	33	6	,	,	,
cord-016293-pyb00pt5	33	7	the	the	DT
cord-016293-pyb00pt5	33	8	estimated	estimate	VBN
cord-016293-pyb00pt5	33	9	number	number	NN
cord-016293-pyb00pt5	33	10	was	be	VBD
cord-016293-pyb00pt5	33	11	guessed	guess	VBN
cord-016293-pyb00pt5	33	12	to	to	TO
cord-016293-pyb00pt5	33	13	be	be	VB
cord-016293-pyb00pt5	33	14	closer	close	JJR
cord-016293-pyb00pt5	33	15	to	to	IN
cord-016293-pyb00pt5	33	16	the	the	DT
cord-016293-pyb00pt5	33	17	actual	actual	JJ
cord-016293-pyb00pt5	33	18	estimate	estimate	NN
cord-016293-pyb00pt5	33	19	of	of	IN
cord-016293-pyb00pt5	33	20	35	35	CD
cord-016293-pyb00pt5	33	21	-	-	SYM
cord-016293-pyb00pt5	33	22	40,000	40,000	CD
cord-016293-pyb00pt5	33	23	(	(	-LRB-
cord-016293-pyb00pt5	33	24	later	later	RB
cord-016293-pyb00pt5	33	25	reduced	reduce	VBN
cord-016293-pyb00pt5	33	26	to	to	IN
cord-016293-pyb00pt5	33	27	20	20	CD
cord-016293-pyb00pt5	33	28	-	-	SYM
cord-016293-pyb00pt5	33	29	25,000	25,000	CD
cord-016293-pyb00pt5	33	30	)	)	-RRB-
cord-016293-pyb00pt5	34	1	this	this	DT
cord-016293-pyb00pt5	34	2	would	would	MD
cord-016293-pyb00pt5	34	3	have	have	VB
cord-016293-pyb00pt5	34	4	made	make	VBN
cord-016293-pyb00pt5	34	5	the	the	DT
cord-016293-pyb00pt5	34	6	task	task	NN
cord-016293-pyb00pt5	34	7	seem	seem	VB
cord-016293-pyb00pt5	34	8	even	even	RB
cord-016293-pyb00pt5	34	9	more	more	RBR
cord-016293-pyb00pt5	34	10	foolhardy	foolhardy	JJ
cord-016293-pyb00pt5	34	11	and	and	CC
cord-016293-pyb00pt5	34	12	less	less	RBR
cord-016293-pyb00pt5	34	13	worthwhile	worthwhile	JJ
cord-016293-pyb00pt5	34	14	to	to	IN
cord-016293-pyb00pt5	34	15	some	some	DT
cord-016293-pyb00pt5	34	16	.	.	.
cord-016293-pyb00pt5	35	1	However	however	RB
cord-016293-pyb00pt5	35	2	,	,	,
cord-016293-pyb00pt5	35	3	the	the	DT
cord-016293-pyb00pt5	35	4	ever	ever	RB
cord-016293-pyb00pt5	35	5	-	-	HYPH
cord-016293-pyb00pt5	35	6	powerful	powerful	JJ
cord-016293-pyb00pt5	35	7	incentive	incentive	NN
cord-016293-pyb00pt5	35	8	of	of	IN
cord-016293-pyb00pt5	35	9	new	new	JJ
cord-016293-pyb00pt5	35	10	diagnostics	diagnostic	NNS
cord-016293-pyb00pt5	35	11	and	and	CC
cord-016293-pyb00pt5	35	12	treatments	treatment	NNS
cord-016293-pyb00pt5	35	13	for	for	IN
cord-016293-pyb00pt5	35	14	human	human	JJ
cord-016293-pyb00pt5	35	15	disease	disease	NN
cord-016293-pyb00pt5	35	16	beyond	beyond	IN
cord-016293-pyb00pt5	35	17	what	what	WP
cord-016293-pyb00pt5	35	18	could	could	MD
cord-016293-pyb00pt5	35	19	be	be	VB
cord-016293-pyb00pt5	35	20	gleaned	glean	VBN
cord-016293-pyb00pt5	35	21	from	from	IN
cord-016293-pyb00pt5	35	22	the	the	DT
cord-016293-pyb00pt5	35	23	gene	gene	NN
cord-016293-pyb00pt5	35	24	-	-	HYPH
cord-016293-pyb00pt5	35	25	by	by	IN
cord-016293-pyb00pt5	35	26	-	-	HYPH
cord-016293-pyb00pt5	35	27	gene	gene	NN
cord-016293-pyb00pt5	35	28	approach	approach	NN
cord-016293-pyb00pt5	35	29	and	and	CC
cord-016293-pyb00pt5	35	30	the	the	DT
cord-016293-pyb00pt5	35	31	rapidly	rapidly	RB
cord-016293-pyb00pt5	35	32	evolving	evolve	VBG
cord-016293-pyb00pt5	35	33	technologies	technology	NNS
cord-016293-pyb00pt5	35	34	,	,	,
cord-016293-pyb00pt5	35	35	especially	especially	RB
cord-016293-pyb00pt5	35	36	that	that	DT
cord-016293-pyb00pt5	35	37	of	of	IN
cord-016293-pyb00pt5	35	38	automated	automate	VBN
cord-016293-pyb00pt5	35	39	sequencing	sequencing	NN
cord-016293-pyb00pt5	35	40	,	,	,
cord-016293-pyb00pt5	35	41	made	make	VBD
cord-016293-pyb00pt5	35	42	it	-PRON-	PRP
cord-016293-pyb00pt5	35	43	both	both	CC
cord-016293-pyb00pt5	35	44	an	an	DT
cord-016293-pyb00pt5	35	45	attractive	attractive	JJ
cord-016293-pyb00pt5	35	46	and	and	CC
cord-016293-pyb00pt5	35	47	plausible	plausible	JJ
cord-016293-pyb00pt5	35	48	aim	aim	NN
cord-016293-pyb00pt5	35	49	.	.	.
cord-016293-pyb00pt5	36	1	Charles	Charles	NNP
cord-016293-pyb00pt5	36	2	Cantor	Cantor	NNP
cord-016293-pyb00pt5	36	3	(	(	-LRB-
cord-016293-pyb00pt5	36	4	1990	1990	CD
cord-016293-pyb00pt5	36	5	)	)	-RRB-
cord-016293-pyb00pt5	36	6	,	,	,
cord-016293-pyb00pt5	36	7	a	a	DT
cord-016293-pyb00pt5	36	8	principal	principal	JJ
cord-016293-pyb00pt5	36	9	scientist	scientist	NN
cord-016293-pyb00pt5	36	10	for	for	IN
cord-016293-pyb00pt5	36	11	the	the	DT
cord-016293-pyb00pt5	36	12	Department	Department	NNP
cord-016293-pyb00pt5	36	13	of	of	IN
cord-016293-pyb00pt5	36	14	Energy	Energy	NNP
cord-016293-pyb00pt5	36	15	's	's	POS
cord-016293-pyb00pt5	36	16	genome	genome	NN
cord-016293-pyb00pt5	36	17	project	project	NN
cord-016293-pyb00pt5	36	18	contended	contend	VBD
cord-016293-pyb00pt5	36	19	that	that	IN
cord-016293-pyb00pt5	36	20	DOE	DOE	NNP
cord-016293-pyb00pt5	36	21	and	and	CC
cord-016293-pyb00pt5	36	22	NIH	NIH	NNP
cord-016293-pyb00pt5	36	23	were	be	VBD
cord-016293-pyb00pt5	36	24	cooperating	cooperate	VBG
cord-016293-pyb00pt5	36	25	effectively	effectively	RB
cord-016293-pyb00pt5	36	26	to	to	TO
cord-016293-pyb00pt5	36	27	develop	develop	VB
cord-016293-pyb00pt5	36	28	organizational	organizational	JJ
cord-016293-pyb00pt5	36	29	structures	structure	NNS
cord-016293-pyb00pt5	36	30	and	and	CC
cord-016293-pyb00pt5	36	31	scientific	scientific	JJ
cord-016293-pyb00pt5	36	32	priorities	priority	NNS
cord-016293-pyb00pt5	36	33	that	that	WDT
cord-016293-pyb00pt5	36	34	would	would	MD
cord-016293-pyb00pt5	36	35	keep	keep	VB
cord-016293-pyb00pt5	36	36	the	the	DT
cord-016293-pyb00pt5	36	37	project	project	NN
cord-016293-pyb00pt5	36	38	on	on	IN
cord-016293-pyb00pt5	36	39	schedule	schedule	NN
cord-016293-pyb00pt5	36	40	and	and	CC
cord-016293-pyb00pt5	36	41	within	within	IN
cord-016293-pyb00pt5	36	42	its	-PRON-	PRP$
cord-016293-pyb00pt5	36	43	budget	budget	NN
cord-016293-pyb00pt5	36	44	.	.	.
cord-016293-pyb00pt5	37	1	He	-PRON-	PRP
cord-016293-pyb00pt5	37	2	noted	note	VBD
cord-016293-pyb00pt5	37	3	that	that	IN
cord-016293-pyb00pt5	37	4	there	there	EX
cord-016293-pyb00pt5	37	5	would	would	MD
cord-016293-pyb00pt5	37	6	be	be	VB
cord-016293-pyb00pt5	37	7	small	small	JJ
cord-016293-pyb00pt5	37	8	short	short	JJ
cord-016293-pyb00pt5	37	9	-	-	HYPH
cord-016293-pyb00pt5	37	10	term	term	NN
cord-016293-pyb00pt5	37	11	costs	cost	NNS
cord-016293-pyb00pt5	37	12	to	to	IN
cord-016293-pyb00pt5	37	13	traditional	traditional	JJ
cord-016293-pyb00pt5	37	14	biology	biology	NN
cord-016293-pyb00pt5	37	15	,	,	,
cord-016293-pyb00pt5	37	16	but	but	CC
cord-016293-pyb00pt5	37	17	that	that	IN
cord-016293-pyb00pt5	37	18	the	the	DT
cord-016293-pyb00pt5	37	19	long	long	JJ
cord-016293-pyb00pt5	37	20	-	-	HYPH
cord-016293-pyb00pt5	37	21	term	term	NN
cord-016293-pyb00pt5	37	22	benefits	benefit	NNS
cord-016293-pyb00pt5	37	23	would	would	MD
cord-016293-pyb00pt5	37	24	be	be	VB
cord-016293-pyb00pt5	37	25	immeasurable	immeasurable	JJ
cord-016293-pyb00pt5	37	26	.	.	.
cord-016293-pyb00pt5	38	1	Genome	genome	NN
cord-016293-pyb00pt5	38	2	projects	project	NNS
cord-016293-pyb00pt5	38	3	were	be	VBD
cord-016293-pyb00pt5	38	4	also	also	RB
cord-016293-pyb00pt5	38	5	discussed	discuss	VBN
cord-016293-pyb00pt5	38	6	and	and	CC
cord-016293-pyb00pt5	38	7	developed	develop	VBN
cord-016293-pyb00pt5	38	8	in	in	IN
cord-016293-pyb00pt5	38	9	other	other	JJ
cord-016293-pyb00pt5	38	10	countries	country	NNS
cord-016293-pyb00pt5	38	11	and	and	CC
cord-016293-pyb00pt5	38	12	sequencing	sequencing	NN
cord-016293-pyb00pt5	38	13	efforts	effort	NNS
cord-016293-pyb00pt5	38	14	began	begin	VBD
cord-016293-pyb00pt5	38	15	in	in	IN
cord-016293-pyb00pt5	38	16	Japan	Japan	NNP
cord-016293-pyb00pt5	38	17	,	,	,
cord-016293-pyb00pt5	38	18	France	France	NNP
cord-016293-pyb00pt5	38	19	,	,	,
cord-016293-pyb00pt5	38	20	Italy	Italy	NNP
cord-016293-pyb00pt5	38	21	,	,	,
cord-016293-pyb00pt5	38	22	the	the	DT
cord-016293-pyb00pt5	38	23	United	United	NNP
cord-016293-pyb00pt5	38	24	Kingdom	Kingdom	NNP
cord-016293-pyb00pt5	38	25	,	,	,
cord-016293-pyb00pt5	38	26	and	and	CC
cord-016293-pyb00pt5	38	27	Canada	Canada	NNP
cord-016293-pyb00pt5	38	28	.	.	.
cord-016293-pyb00pt5	39	1	Even	even	RB
cord-016293-pyb00pt5	39	2	as	as	IN
cord-016293-pyb00pt5	39	3	the	the	DT
cord-016293-pyb00pt5	39	4	Soviet	Soviet	NNP
cord-016293-pyb00pt5	39	5	Union	Union	NNP
cord-016293-pyb00pt5	39	6	collapsed	collapse	VBD
cord-016293-pyb00pt5	39	7	,	,	,
cord-016293-pyb00pt5	39	8	a	a	DT
cord-016293-pyb00pt5	39	9	genome	genome	NN
cord-016293-pyb00pt5	39	10	project	project	NN
cord-016293-pyb00pt5	39	11	survived	survive	VBD
cord-016293-pyb00pt5	39	12	as	as	IN
cord-016293-pyb00pt5	39	13	part	part	NN
cord-016293-pyb00pt5	39	14	of	of	IN
cord-016293-pyb00pt5	39	15	the	the	DT
cord-016293-pyb00pt5	39	16	Russian	russian	JJ
cord-016293-pyb00pt5	39	17	science	science	NN
cord-016293-pyb00pt5	39	18	program	program	NN
cord-016293-pyb00pt5	39	19	.	.	.
cord-016293-pyb00pt5	40	1	The	the	DT
cord-016293-pyb00pt5	40	2	scale	scale	NN
cord-016293-pyb00pt5	40	3	of	of	IN
cord-016293-pyb00pt5	40	4	the	the	DT
cord-016293-pyb00pt5	40	5	venture	venture	NN
cord-016293-pyb00pt5	40	6	and	and	CC
cord-016293-pyb00pt5	40	7	the	the	DT
cord-016293-pyb00pt5	40	8	manageable	manageable	JJ
cord-016293-pyb00pt5	40	9	prospect	prospect	NN
cord-016293-pyb00pt5	40	10	for	for	IN
cord-016293-pyb00pt5	40	11	pooling	pool	VBG
cord-016293-pyb00pt5	40	12	data	datum	NNS
cord-016293-pyb00pt5	40	13	via	via	IN
cord-016293-pyb00pt5	40	14	computer	computer	NN
cord-016293-pyb00pt5	40	15	made	make	VBD
cord-016293-pyb00pt5	40	16	sequencing	sequence	VBG
cord-016293-pyb00pt5	40	17	the	the	DT
cord-016293-pyb00pt5	40	18	human	human	JJ
cord-016293-pyb00pt5	40	19	genome	genome	NN
cord-016293-pyb00pt5	40	20	a	a	DT
cord-016293-pyb00pt5	40	21	truly	truly	RB
cord-016293-pyb00pt5	40	22	international	international	JJ
cord-016293-pyb00pt5	40	23	initiative	initiative	NN
cord-016293-pyb00pt5	40	24	.	.	.
cord-016293-pyb00pt5	41	1	In	in	IN
cord-016293-pyb00pt5	41	2	an	an	DT
cord-016293-pyb00pt5	41	3	effort	effort	NN
cord-016293-pyb00pt5	41	4	to	to	TO
cord-016293-pyb00pt5	41	5	include	include	VB
cord-016293-pyb00pt5	41	6	developing	develop	VBG
cord-016293-pyb00pt5	41	7	countries	country	NNS
cord-016293-pyb00pt5	41	8	in	in	IN
cord-016293-pyb00pt5	41	9	the	the	DT
cord-016293-pyb00pt5	41	10	project	project	NN
cord-016293-pyb00pt5	41	11	UNESCO	UNESCO	NNP
cord-016293-pyb00pt5	41	12	assembled	assemble	VBD
cord-016293-pyb00pt5	41	13	an	an	DT
cord-016293-pyb00pt5	41	14	advisory	advisory	JJ
cord-016293-pyb00pt5	41	15	committee	committee	NN
cord-016293-pyb00pt5	41	16	in	in	IN
cord-016293-pyb00pt5	41	17	1988	1988	CD
cord-016293-pyb00pt5	41	18	to	to	TO
cord-016293-pyb00pt5	41	19	examine	examine	VB
cord-016293-pyb00pt5	41	20	UNESCO	UNESCO	NNP
cord-016293-pyb00pt5	41	21	's	's	POS
cord-016293-pyb00pt5	41	22	role	role	NN
cord-016293-pyb00pt5	41	23	in	in	IN
cord-016293-pyb00pt5	41	24	facilitating	facilitate	VBG
cord-016293-pyb00pt5	41	25	international	international	JJ
cord-016293-pyb00pt5	41	26	dialogue	dialogue	NN
cord-016293-pyb00pt5	41	27	and	and	CC
cord-016293-pyb00pt5	41	28	cooperation	cooperation	NN
cord-016293-pyb00pt5	41	29	.	.	.
cord-016293-pyb00pt5	42	1	A	a	DT
cord-016293-pyb00pt5	42	2	privately	privately	RB
cord-016293-pyb00pt5	42	3	-	-	HYPH
cord-016293-pyb00pt5	42	4	funded	fund	VBN
cord-016293-pyb00pt5	42	5	Human	Human	NNP
cord-016293-pyb00pt5	42	6	Genome	Genome	NNP
cord-016293-pyb00pt5	42	7	Organization	Organization	NNP
cord-016293-pyb00pt5	42	8	(	(	-LRB-
cord-016293-pyb00pt5	42	9	HUGO	HUGO	NNP
cord-016293-pyb00pt5	42	10	)	)	-RRB-
cord-016293-pyb00pt5	42	11	had	have	VBD
cord-016293-pyb00pt5	42	12	been	be	VBN
cord-016293-pyb00pt5	42	13	founded	found	VBN
cord-016293-pyb00pt5	42	14	in	in	IN
cord-016293-pyb00pt5	42	15	1988	1988	CD
cord-016293-pyb00pt5	42	16	to	to	TO
cord-016293-pyb00pt5	42	17	coordinate	coordinate	VB
cord-016293-pyb00pt5	42	18	international	international	JJ
cord-016293-pyb00pt5	42	19	efforts	effort	NNS
cord-016293-pyb00pt5	42	20	and	and	CC
cord-016293-pyb00pt5	42	21	serve	serve	VB
cord-016293-pyb00pt5	42	22	as	as	IN
cord-016293-pyb00pt5	42	23	a	a	DT
cord-016293-pyb00pt5	42	24	clearinghouse	clearinghouse	NN
cord-016293-pyb00pt5	42	25	for	for	IN
cord-016293-pyb00pt5	42	26	data	datum	NNS
cord-016293-pyb00pt5	42	27	.	.	.
cord-016293-pyb00pt5	43	1	In	in	IN
cord-016293-pyb00pt5	43	2	that	that	DT
cord-016293-pyb00pt5	43	3	same	same	JJ
cord-016293-pyb00pt5	43	4	year	year	NN
cord-016293-pyb00pt5	43	5	the	the	DT
cord-016293-pyb00pt5	43	6	European	European	NNP
cord-016293-pyb00pt5	43	7	Commission	Commission	NNP
cord-016293-pyb00pt5	43	8	(	(	-LRB-
cord-016293-pyb00pt5	43	9	EC	EC	NNP
cord-016293-pyb00pt5	43	10	)	)	-RRB-
cord-016293-pyb00pt5	43	11	introduced	introduce	VBD
cord-016293-pyb00pt5	43	12	a	a	DT
cord-016293-pyb00pt5	43	13	proposal	proposal	NN
cord-016293-pyb00pt5	43	14	entitled	entitle	VBN
cord-016293-pyb00pt5	43	15	the	the	DT
cord-016293-pyb00pt5	43	16	"	"	``
cord-016293-pyb00pt5	43	17	Predictive	Predictive	NNP
cord-016293-pyb00pt5	43	18	Medicine	Medicine	NNP
cord-016293-pyb00pt5	43	19	Programme	Programme	NNP
cord-016293-pyb00pt5	43	20	.	.	.
cord-016293-pyb00pt5	44	1	"	"	''
cord-016293-pyb00pt5	45	1	A	a	DT
cord-016293-pyb00pt5	45	2	few	few	JJ
cord-016293-pyb00pt5	45	3	EC	EC	NNP
cord-016293-pyb00pt5	45	4	countries	country	NNS
cord-016293-pyb00pt5	45	5	,	,	,
cord-016293-pyb00pt5	45	6	notably	notably	RB
cord-016293-pyb00pt5	45	7	Germany	Germany	NNP
cord-016293-pyb00pt5	45	8	and	and	CC
cord-016293-pyb00pt5	45	9	Denmark	Denmark	NNP
cord-016293-pyb00pt5	45	10	,	,	,
cord-016293-pyb00pt5	45	11	claimed	claim	VBD
cord-016293-pyb00pt5	45	12	the	the	DT
cord-016293-pyb00pt5	45	13	proposal	proposal	NN
cord-016293-pyb00pt5	45	14	lacked	lack	VBD
cord-016293-pyb00pt5	45	15	ethical	ethical	JJ
cord-016293-pyb00pt5	45	16	sensitivity	sensitivity	NN
cord-016293-pyb00pt5	45	17	;	;	:
cord-016293-pyb00pt5	45	18	objections	objection	NNS
cord-016293-pyb00pt5	45	19	to	to	IN
cord-016293-pyb00pt5	45	20	the	the	DT
cord-016293-pyb00pt5	45	21	possible	possible	JJ
cord-016293-pyb00pt5	45	22	eugenic	eugenic	JJ
cord-016293-pyb00pt5	45	23	implications	implication	NNS
cord-016293-pyb00pt5	45	24	of	of	IN
cord-016293-pyb00pt5	45	25	the	the	DT
cord-016293-pyb00pt5	45	26	program	program	NN
cord-016293-pyb00pt5	45	27	were	be	VBD
cord-016293-pyb00pt5	45	28	especially	especially	RB
cord-016293-pyb00pt5	45	29	strong	strong	JJ
cord-016293-pyb00pt5	45	30	in	in	IN
cord-016293-pyb00pt5	45	31	Germany	Germany	NNP
cord-016293-pyb00pt5	45	32	(	(	-LRB-
cord-016293-pyb00pt5	45	33	Dickson	Dickson	NNP
cord-016293-pyb00pt5	45	34	1989	1989	CD
cord-016293-pyb00pt5	45	35	)	)	-RRB-
cord-016293-pyb00pt5	45	36	.	.	.
cord-016293-pyb00pt5	46	1	The	the	DT
cord-016293-pyb00pt5	46	2	initial	initial	JJ
cord-016293-pyb00pt5	46	3	proposal	proposal	NN
cord-016293-pyb00pt5	46	4	was	be	VBD
cord-016293-pyb00pt5	46	5	dropped	drop	VBN
cord-016293-pyb00pt5	46	6	but	but	CC
cord-016293-pyb00pt5	46	7	later	later	RB
cord-016293-pyb00pt5	46	8	modified	modify	VBN
cord-016293-pyb00pt5	46	9	and	and	CC
cord-016293-pyb00pt5	46	10	adopted	adopt	VBN
cord-016293-pyb00pt5	46	11	in	in	IN
cord-016293-pyb00pt5	46	12	1990	1990	CD
cord-016293-pyb00pt5	46	13	as	as	IN
cord-016293-pyb00pt5	46	14	the	the	DT
cord-016293-pyb00pt5	46	15	"	"	``
cord-016293-pyb00pt5	46	16	Human	Human	NNP
cord-016293-pyb00pt5	46	17	Genome	Genome	NNP
cord-016293-pyb00pt5	46	18	Analysis	Analysis	NNP
cord-016293-pyb00pt5	46	19	Programme	Programme	NNP
cord-016293-pyb00pt5	46	20	"	"	''
cord-016293-pyb00pt5	46	21	(	(	-LRB-
cord-016293-pyb00pt5	46	22	Dickman	Dickman	NNP
cord-016293-pyb00pt5	46	23	and	and	CC
cord-016293-pyb00pt5	46	24	Aldhous	Aldhous	NNP
cord-016293-pyb00pt5	46	25	1991	1991	CD
cord-016293-pyb00pt5	46	26	)	)	-RRB-
cord-016293-pyb00pt5	46	27	.	.	.
cord-016293-pyb00pt5	47	1	This	this	DT
cord-016293-pyb00pt5	47	2	program	program	NN
cord-016293-pyb00pt5	47	3	committed	commit	VBD
cord-016293-pyb00pt5	47	4	substantial	substantial	JJ
cord-016293-pyb00pt5	47	5	resources	resource	NNS
cord-016293-pyb00pt5	47	6	to	to	IN
cord-016293-pyb00pt5	47	7	the	the	DT
cord-016293-pyb00pt5	47	8	study	study	NN
cord-016293-pyb00pt5	47	9	of	of	IN
cord-016293-pyb00pt5	47	10	ethical	ethical	JJ
cord-016293-pyb00pt5	47	11	issues	issue	NNS
cord-016293-pyb00pt5	47	12	.	.	.
cord-016293-pyb00pt5	48	1	The	the	DT
cord-016293-pyb00pt5	48	2	need	need	NN
cord-016293-pyb00pt5	48	3	for	for	IN
cord-016293-pyb00pt5	48	4	an	an	DT
cord-016293-pyb00pt5	48	5	organization	organization	NN
cord-016293-pyb00pt5	48	6	to	to	TO
cord-016293-pyb00pt5	48	7	coordinate	coordinate	VB
cord-016293-pyb00pt5	48	8	these	these	DT
cord-016293-pyb00pt5	48	9	multiple	multiple	JJ
cord-016293-pyb00pt5	48	10	international	international	JJ
cord-016293-pyb00pt5	48	11	efforts	effort	NNS
cord-016293-pyb00pt5	48	12	quickly	quickly	RB
cord-016293-pyb00pt5	48	13	became	become	VBD
cord-016293-pyb00pt5	48	14	apparent	apparent	JJ
cord-016293-pyb00pt5	48	15	.	.	.
cord-016293-pyb00pt5	49	1	Thus	thus	RB
cord-016293-pyb00pt5	49	2	the	the	DT
cord-016293-pyb00pt5	49	3	Human	Human	NNP
cord-016293-pyb00pt5	49	4	Genome	Genome	NNP
cord-016293-pyb00pt5	49	5	Organization	Organization	NNP
cord-016293-pyb00pt5	49	6	(	(	-LRB-
cord-016293-pyb00pt5	49	7	HUGO	HUGO	NNP
cord-016293-pyb00pt5	49	8	)	)	-RRB-
cord-016293-pyb00pt5	49	9	,	,	,
cord-016293-pyb00pt5	49	10	which	which	WDT
cord-016293-pyb00pt5	49	11	has	have	VBZ
cord-016293-pyb00pt5	49	12	been	be	VBN
cord-016293-pyb00pt5	49	13	called	call	VBN
cord-016293-pyb00pt5	49	14	the	the	DT
cord-016293-pyb00pt5	49	15	"	"	``
cord-016293-pyb00pt5	49	16	U.N.	U.N.	NNP
cord-016293-pyb00pt5	49	17	for	for	IN
cord-016293-pyb00pt5	49	18	the	the	DT
cord-016293-pyb00pt5	49	19	human	human	JJ
cord-016293-pyb00pt5	49	20	genome	genome	NN
cord-016293-pyb00pt5	49	21	,	,	,
cord-016293-pyb00pt5	49	22	"	"	''
cord-016293-pyb00pt5	49	23	was	be	VBD
cord-016293-pyb00pt5	49	24	born	bear	VBN
cord-016293-pyb00pt5	49	25	in	in	IN
cord-016293-pyb00pt5	49	26	the	the	DT
cord-016293-pyb00pt5	49	27	spring	spring	NN
cord-016293-pyb00pt5	49	28	of	of	IN
cord-016293-pyb00pt5	49	29	1988	1988	CD
cord-016293-pyb00pt5	49	30	.	.	.
cord-016293-pyb00pt5	50	1	Composed	compose	VBN
cord-016293-pyb00pt5	50	2	of	of	IN
cord-016293-pyb00pt5	50	3	a	a	DT
cord-016293-pyb00pt5	50	4	founding	found	VBG
cord-016293-pyb00pt5	50	5	council	council	NN
cord-016293-pyb00pt5	50	6	of	of	IN
cord-016293-pyb00pt5	50	7	scientists	scientist	NNS
cord-016293-pyb00pt5	50	8	from	from	IN
cord-016293-pyb00pt5	50	9	seventeen	seventeen	CD
cord-016293-pyb00pt5	50	10	countries	country	NNS
cord-016293-pyb00pt5	50	11	,	,	,
cord-016293-pyb00pt5	50	12	HUGO	HUGO	NNP
cord-016293-pyb00pt5	50	13	's	's	POS
cord-016293-pyb00pt5	50	14	goal	goal	NN
cord-016293-pyb00pt5	50	15	was	be	VBD
cord-016293-pyb00pt5	50	16	to	to	TO
cord-016293-pyb00pt5	50	17	encourage	encourage	VB
cord-016293-pyb00pt5	50	18	international	international	JJ
cord-016293-pyb00pt5	50	19	collaboration	collaboration	NN
cord-016293-pyb00pt5	50	20	through	through	IN
cord-016293-pyb00pt5	50	21	coordination	coordination	NN
cord-016293-pyb00pt5	50	22	of	of	IN
cord-016293-pyb00pt5	50	23	research	research	NN
cord-016293-pyb00pt5	50	24	,	,	,
cord-016293-pyb00pt5	50	25	exchange	exchange	NN
cord-016293-pyb00pt5	50	26	of	of	IN
cord-016293-pyb00pt5	50	27	data	datum	NNS
cord-016293-pyb00pt5	50	28	and	and	CC
cord-016293-pyb00pt5	50	29	research	research	NN
cord-016293-pyb00pt5	50	30	techniques	technique	NNS
cord-016293-pyb00pt5	50	31	,	,	,
cord-016293-pyb00pt5	50	32	training	training	NN
cord-016293-pyb00pt5	50	33	,	,	,
cord-016293-pyb00pt5	50	34	and	and	CC
cord-016293-pyb00pt5	50	35	debates	debate	NNS
cord-016293-pyb00pt5	50	36	on	on	IN
cord-016293-pyb00pt5	50	37	the	the	DT
cord-016293-pyb00pt5	50	38	implications	implication	NNS
cord-016293-pyb00pt5	50	39	of	of	IN
cord-016293-pyb00pt5	50	40	the	the	DT
cord-016293-pyb00pt5	50	41	projects	project	NNS
cord-016293-pyb00pt5	50	42	(	(	-LRB-
cord-016293-pyb00pt5	50	43	Bodmer	Bodmer	NNP
cord-016293-pyb00pt5	50	44	1991	1991	CD
cord-016293-pyb00pt5	50	45	)	)	-RRB-
cord-016293-pyb00pt5	50	46	.	.	.
cord-016293-pyb00pt5	51	1	In	in	IN
cord-016293-pyb00pt5	51	2	August	August	NNP
cord-016293-pyb00pt5	51	3	1990	1990	CD
cord-016293-pyb00pt5	51	4	NIH	NIH	NNP
cord-016293-pyb00pt5	51	5	began	begin	VBD
cord-016293-pyb00pt5	51	6	large	large	JJ
cord-016293-pyb00pt5	51	7	-	-	HYPH
cord-016293-pyb00pt5	51	8	scale	scale	NN
cord-016293-pyb00pt5	51	9	sequencing	sequencing	NN
cord-016293-pyb00pt5	51	10	trials	trial	NNS
cord-016293-pyb00pt5	51	11	on	on	IN
cord-016293-pyb00pt5	51	12	four	four	CD
cord-016293-pyb00pt5	51	13	model	model	NN
cord-016293-pyb00pt5	51	14	organisms	organism	NNS
cord-016293-pyb00pt5	51	15	:	:	:
cord-016293-pyb00pt5	51	16	the	the	DT
cord-016293-pyb00pt5	51	17	parasitic	parasitic	JJ
cord-016293-pyb00pt5	51	18	,	,	,
cord-016293-pyb00pt5	51	19	cell	cell	NN
cord-016293-pyb00pt5	51	20	-	-	HYPH
cord-016293-pyb00pt5	51	21	wall	wall	NN
cord-016293-pyb00pt5	51	22	lacking	lack	VBG
cord-016293-pyb00pt5	51	23	pathogenic	pathogenic	JJ
cord-016293-pyb00pt5	51	24	microbe	microbe	NN
cord-016293-pyb00pt5	51	25	Mycoplasma	Mycoplasma	NNP
cord-016293-pyb00pt5	51	26	capricolum	capricolum	NN
cord-016293-pyb00pt5	51	27	,	,	,
cord-016293-pyb00pt5	51	28	the	the	DT
cord-016293-pyb00pt5	51	29	prokaryotic	prokaryotic	JJ
cord-016293-pyb00pt5	51	30	microbial	microbial	JJ
cord-016293-pyb00pt5	51	31	lab	lab	NN
cord-016293-pyb00pt5	51	32	rat	rat	NN
cord-016293-pyb00pt5	51	33	Escherichia	Escherichia	NNP
cord-016293-pyb00pt5	51	34	coli	coli	NNS
cord-016293-pyb00pt5	51	35	,	,	,
cord-016293-pyb00pt5	51	36	the	the	DT
cord-016293-pyb00pt5	51	37	most	most	RBS
cord-016293-pyb00pt5	51	38	simple	simple	JJ
cord-016293-pyb00pt5	51	39	animal	animal	NN
cord-016293-pyb00pt5	51	40	Caenorhabditis	Caenorhabditis	NNP
cord-016293-pyb00pt5	51	41	elegans	elegan	NNS
cord-016293-pyb00pt5	51	42	,	,	,
cord-016293-pyb00pt5	51	43	and	and	CC
cord-016293-pyb00pt5	51	44	the	the	DT
cord-016293-pyb00pt5	51	45	eukaryotic	eukaryotic	JJ
cord-016293-pyb00pt5	51	46	microbial	microbial	JJ
cord-016293-pyb00pt5	51	47	lab	lab	NN
cord-016293-pyb00pt5	51	48	rat	rat	NN
cord-016293-pyb00pt5	51	49	Saccharomyces	Saccharomyces	NNP
cord-016293-pyb00pt5	51	50	cerevisiae	cerevisiae	NNS
cord-016293-pyb00pt5	51	51	.	.	.
cord-016293-pyb00pt5	52	1	Each	each	DT
cord-016293-pyb00pt5	52	2	research	research	NN
cord-016293-pyb00pt5	52	3	group	group	NN
cord-016293-pyb00pt5	52	4	agreed	agree	VBD
cord-016293-pyb00pt5	52	5	to	to	TO
cord-016293-pyb00pt5	52	6	sequence	sequence	VB
cord-016293-pyb00pt5	52	7	3	3	CD
cord-016293-pyb00pt5	52	8	megabases	megabase	NNS
cord-016293-pyb00pt5	52	9	(	(	-LRB-
cord-016293-pyb00pt5	52	10	Mb	Mb	NNP
cord-016293-pyb00pt5	52	11	)	)	-RRB-
cord-016293-pyb00pt5	52	12	at	at	IN
cord-016293-pyb00pt5	52	13	75	75	CD
cord-016293-pyb00pt5	52	14	cents	cent	NNS
cord-016293-pyb00pt5	52	15	a	a	DT
cord-016293-pyb00pt5	52	16	base	base	NN
cord-016293-pyb00pt5	52	17	within	within	IN
cord-016293-pyb00pt5	52	18	3	3	CD
cord-016293-pyb00pt5	52	19	years	year	NNS
cord-016293-pyb00pt5	52	20	.	.	.
cord-016293-pyb00pt5	53	1	A	a	DT
cord-016293-pyb00pt5	53	2	sub	sub	NN
cord-016293-pyb00pt5	53	3	living	live	VBG
cord-016293-pyb00pt5	53	4	organism	organism	NN
cord-016293-pyb00pt5	53	5	was	be	VBD
cord-016293-pyb00pt5	53	6	actually	actually	RB
cord-016293-pyb00pt5	53	7	fully	fully	RB
cord-016293-pyb00pt5	53	8	sequenced	sequence	VBN
cord-016293-pyb00pt5	53	9	and	and	CC
cord-016293-pyb00pt5	53	10	the	the	DT
cord-016293-pyb00pt5	53	11	complete	complete	JJ
cord-016293-pyb00pt5	53	12	sequence	sequence	NN
cord-016293-pyb00pt5	53	13	of	of	IN
cord-016293-pyb00pt5	53	14	that	that	DT
cord-016293-pyb00pt5	53	15	genome	genome	NN
cord-016293-pyb00pt5	53	16	,	,	,
cord-016293-pyb00pt5	54	1	the	the	DT
cord-016293-pyb00pt5	54	2	human	human	JJ
cord-016293-pyb00pt5	54	3	cytomegalovirus	cytomegalovirus	NN
cord-016293-pyb00pt5	54	4	(	(	-LRB-
cord-016293-pyb00pt5	54	5	HCMV	HCMV	NNP
cord-016293-pyb00pt5	54	6	)	)	-RRB-
cord-016293-pyb00pt5	54	7	genome	genome	NN
cord-016293-pyb00pt5	54	8	was	be	VBD
cord-016293-pyb00pt5	54	9	0.23	0.23	CD
cord-016293-pyb00pt5	54	10	Mb	Mb	NNS
cord-016293-pyb00pt5	54	11	.	.	.
cord-016293-pyb00pt5	55	1	That	that	DT
cord-016293-pyb00pt5	55	2	year	year	NN
cord-016293-pyb00pt5	55	3	also	also	RB
cord-016293-pyb00pt5	55	4	saw	see	VBD
cord-016293-pyb00pt5	55	5	the	the	DT
cord-016293-pyb00pt5	55	6	casting	casting	NN
cord-016293-pyb00pt5	55	7	of	of	IN
cord-016293-pyb00pt5	55	8	the	the	DT
cord-016293-pyb00pt5	55	9	first	first	JJ
cord-016293-pyb00pt5	55	10	salvo	salvo	NN
cord-016293-pyb00pt5	55	11	in	in	IN
cord-016293-pyb00pt5	55	12	the	the	DT
cord-016293-pyb00pt5	55	13	protracted	protracted	JJ
cord-016293-pyb00pt5	55	14	debate	debate	NN
cord-016293-pyb00pt5	55	15	on	on	IN
cord-016293-pyb00pt5	55	16	"	"	``
cord-016293-pyb00pt5	55	17	ownership	ownership	NN
cord-016293-pyb00pt5	55	18	"	"	''
cord-016293-pyb00pt5	55	19	of	of	IN
cord-016293-pyb00pt5	55	20	genetic	genetic	JJ
cord-016293-pyb00pt5	55	21	information	information	NN
cord-016293-pyb00pt5	55	22	beginning	begin	VBG
cord-016293-pyb00pt5	55	23	with	with	IN
cord-016293-pyb00pt5	55	24	the	the	DT
cord-016293-pyb00pt5	55	25	more	more	RBR
cord-016293-pyb00pt5	55	26	tangible	tangible	JJ
cord-016293-pyb00pt5	55	27	question	question	NN
cord-016293-pyb00pt5	55	28	of	of	IN
cord-016293-pyb00pt5	55	29	ownership	ownership	NN
cord-016293-pyb00pt5	55	30	of	of	IN
cord-016293-pyb00pt5	55	31	cells	cell	NNS
cord-016293-pyb00pt5	55	32	.	.	.
cord-016293-pyb00pt5	56	1	And	and	CC
cord-016293-pyb00pt5	56	2	,	,	,
cord-016293-pyb00pt5	56	3	as	as	IN
cord-016293-pyb00pt5	56	4	with	with	IN
cord-016293-pyb00pt5	56	5	the	the	DT
cord-016293-pyb00pt5	56	6	debates	debate	NNS
cord-016293-pyb00pt5	56	7	of	of	IN
cord-016293-pyb00pt5	56	8	the	the	DT
cord-016293-pyb00pt5	56	9	early	early	JJ
cord-016293-pyb00pt5	56	10	eighties	eighty	NNS
cord-016293-pyb00pt5	56	11	,	,	,
cord-016293-pyb00pt5	56	12	which	which	WDT
cord-016293-pyb00pt5	56	13	were	be	VBD
cord-016293-pyb00pt5	56	14	to	to	TO
cord-016293-pyb00pt5	56	15	be	be	VB
cord-016293-pyb00pt5	56	16	revisited	revisit	VBN
cord-016293-pyb00pt5	56	17	later	later	RB
cord-016293-pyb00pt5	56	18	in	in	IN
cord-016293-pyb00pt5	56	19	the	the	DT
cord-016293-pyb00pt5	56	20	nineties	ninety	NNS
cord-016293-pyb00pt5	56	21	,	,	,
cord-016293-pyb00pt5	56	22	the	the	DT
cord-016293-pyb00pt5	56	23	respondent	respondent	NN
cord-016293-pyb00pt5	56	24	was	be	VBD
cord-016293-pyb00pt5	56	25	the	the	DT
cord-016293-pyb00pt5	56	26	University	University	NNP
cord-016293-pyb00pt5	56	27	of	of	IN
cord-016293-pyb00pt5	56	28	California	California	NNP
cord-016293-pyb00pt5	56	29	.	.	.
cord-016293-pyb00pt5	57	1	Moore	Moore	NNP
cord-016293-pyb00pt5	57	2	v.	v.	IN
cord-016293-pyb00pt5	57	3	Regents	Regents	NNPS
cord-016293-pyb00pt5	57	4	of	of	IN
cord-016293-pyb00pt5	57	5	the	the	DT
cord-016293-pyb00pt5	57	6	University	University	NNP
cord-016293-pyb00pt5	57	7	of	of	IN
cord-016293-pyb00pt5	57	8	California	California	NNP
cord-016293-pyb00pt5	57	9	was	be	VBD
cord-016293-pyb00pt5	57	10	the	the	DT
cord-016293-pyb00pt5	57	11	first	first	JJ
cord-016293-pyb00pt5	57	12	case	case	NN
cord-016293-pyb00pt5	57	13	in	in	IN
cord-016293-pyb00pt5	57	14	the	the	DT
cord-016293-pyb00pt5	57	15	United	United	NNP
cord-016293-pyb00pt5	57	16	States	States	NNP
cord-016293-pyb00pt5	57	17	to	to	TO
cord-016293-pyb00pt5	57	18	address	address	VB
cord-016293-pyb00pt5	57	19	the	the	DT
cord-016293-pyb00pt5	57	20	issue	issue	NN
cord-016293-pyb00pt5	57	21	of	of	IN
cord-016293-pyb00pt5	57	22	who	who	WP
cord-016293-pyb00pt5	57	23	owns	own	VBZ
cord-016293-pyb00pt5	57	24	the	the	DT
cord-016293-pyb00pt5	57	25	rights	right	NNS
cord-016293-pyb00pt5	57	26	to	to	IN
cord-016293-pyb00pt5	57	27	an	an	DT
cord-016293-pyb00pt5	57	28	individual	individual	NN
cord-016293-pyb00pt5	57	29	's	's	POS
cord-016293-pyb00pt5	57	30	cells	cell	NNS
cord-016293-pyb00pt5	57	31	.	.	.
cord-016293-pyb00pt5	58	1	Diagnosed	diagnose	VBN
cord-016293-pyb00pt5	58	2	with	with	IN
cord-016293-pyb00pt5	58	3	leukemia	leukemia	NN
cord-016293-pyb00pt5	58	4	,	,	,
cord-016293-pyb00pt5	58	5	John	John	NNP
cord-016293-pyb00pt5	58	6	Moore	Moore	NNP
cord-016293-pyb00pt5	58	7	had	have	VBD
cord-016293-pyb00pt5	58	8	blood	blood	NN
cord-016293-pyb00pt5	58	9	and	and	CC
cord-016293-pyb00pt5	58	10	bone	bone	NN
cord-016293-pyb00pt5	58	11	marrow	marrow	NN
cord-016293-pyb00pt5	58	12	withdrawn	withdraw	VBN
cord-016293-pyb00pt5	58	13	for	for	IN
cord-016293-pyb00pt5	58	14	medical	medical	JJ
cord-016293-pyb00pt5	58	15	tests	test	NNS
cord-016293-pyb00pt5	58	16	.	.	.
cord-016293-pyb00pt5	59	1	Suspicious	suspicious	JJ
cord-016293-pyb00pt5	59	2	of	of	IN
cord-016293-pyb00pt5	59	3	repeated	repeat	VBN
cord-016293-pyb00pt5	59	4	requests	request	NNS
cord-016293-pyb00pt5	59	5	to	to	TO
cord-016293-pyb00pt5	59	6	give	give	VB
cord-016293-pyb00pt5	59	7	samples	sample	NNS
cord-016293-pyb00pt5	59	8	because	because	IN
cord-016293-pyb00pt5	59	9	he	-PRON-	PRP
cord-016293-pyb00pt5	59	10	had	have	VBD
cord-016293-pyb00pt5	59	11	already	already	RB
cord-016293-pyb00pt5	59	12	been	be	VBN
cord-016293-pyb00pt5	59	13	cured	cure	VBN
cord-016293-pyb00pt5	59	14	,	,	,
cord-016293-pyb00pt5	59	15	Moore	Moore	NNP
cord-016293-pyb00pt5	59	16	discovered	discover	VBD
cord-016293-pyb00pt5	59	17	that	that	IN
cord-016293-pyb00pt5	59	18	his	-PRON-	PRP$
cord-016293-pyb00pt5	59	19	doctors	doctor	NNS
cord-016293-pyb00pt5	59	20	had	have	VBD
cord-016293-pyb00pt5	59	21	patented	patent	VBN
cord-016293-pyb00pt5	59	22	a	a	DT
cord-016293-pyb00pt5	59	23	cell	cell	NN
cord-016293-pyb00pt5	59	24	line	line	NN
cord-016293-pyb00pt5	59	25	derived	derive	VBN
cord-016293-pyb00pt5	59	26	from	from	IN
cord-016293-pyb00pt5	59	27	his	-PRON-	PRP$
cord-016293-pyb00pt5	59	28	cells	cell	NNS
cord-016293-pyb00pt5	59	29	and	and	CC
cord-016293-pyb00pt5	59	30	so	so	RB
cord-016293-pyb00pt5	59	31	he	-PRON-	PRP
cord-016293-pyb00pt5	59	32	sued	sue	VBD
cord-016293-pyb00pt5	59	33	.	.	.
cord-016293-pyb00pt5	60	1	The	the	DT
cord-016293-pyb00pt5	60	2	California	California	NNP
cord-016293-pyb00pt5	60	3	Supreme	Supreme	NNP
cord-016293-pyb00pt5	60	4	Court	Court	NNP
cord-016293-pyb00pt5	60	5	found	find	VBD
cord-016293-pyb00pt5	60	6	that	that	IN
cord-016293-pyb00pt5	60	7	Moore	Moore	NNP
cord-016293-pyb00pt5	60	8	's	's	POS
cord-016293-pyb00pt5	60	9	doctor	doctor	NN
cord-016293-pyb00pt5	60	10	did	do	VBD
cord-016293-pyb00pt5	60	11	not	not	RB
cord-016293-pyb00pt5	60	12	obtain	obtain	VB
cord-016293-pyb00pt5	60	13	proper	proper	JJ
cord-016293-pyb00pt5	60	14	informed	informed	JJ
cord-016293-pyb00pt5	60	15	consent	consent	NN
cord-016293-pyb00pt5	60	16	,	,	,
cord-016293-pyb00pt5	60	17	but	but	CC
cord-016293-pyb00pt5	60	18	,	,	,
cord-016293-pyb00pt5	60	19	however	however	RB
cord-016293-pyb00pt5	60	20	,	,	,
cord-016293-pyb00pt5	60	21	they	-PRON-	PRP
cord-016293-pyb00pt5	60	22	also	also	RB
cord-016293-pyb00pt5	60	23	found	find	VBD
cord-016293-pyb00pt5	60	24	that	that	IN
cord-016293-pyb00pt5	60	25	Moore	Moore	NNP
cord-016293-pyb00pt5	60	26	can	can	MD
cord-016293-pyb00pt5	60	27	not	not	RB
cord-016293-pyb00pt5	60	28	claim	claim	VB
cord-016293-pyb00pt5	60	29	property	property	NN
cord-016293-pyb00pt5	60	30	rights	right	NNS
cord-016293-pyb00pt5	60	31	over	over	IN
cord-016293-pyb00pt5	60	32	his	-PRON-	PRP$
cord-016293-pyb00pt5	60	33	body	body	NN
cord-016293-pyb00pt5	60	34	.	.	.
cord-016293-pyb00pt5	61	1	The	the	DT
cord-016293-pyb00pt5	61	2	quest	quest	NN
cord-016293-pyb00pt5	61	3	for	for	IN
cord-016293-pyb00pt5	61	4	the	the	DT
cord-016293-pyb00pt5	61	5	holy	holy	NNP
cord-016293-pyb00pt5	61	6	grail	grail	NNP
cord-016293-pyb00pt5	61	7	of	of	IN
cord-016293-pyb00pt5	61	8	the	the	DT
cord-016293-pyb00pt5	61	9	human	human	JJ
cord-016293-pyb00pt5	61	10	genome	genome	NN
cord-016293-pyb00pt5	61	11	was	be	VBD
cord-016293-pyb00pt5	61	12	both	both	DT
cord-016293-pyb00pt5	61	13	inspired	inspire	VBN
cord-016293-pyb00pt5	61	14	by	by	IN
cord-016293-pyb00pt5	61	15	the	the	DT
cord-016293-pyb00pt5	61	16	rapidly	rapidly	RB
cord-016293-pyb00pt5	61	17	evolving	evolve	VBG
cord-016293-pyb00pt5	61	18	technologies	technology	NNS
cord-016293-pyb00pt5	61	19	for	for	IN
cord-016293-pyb00pt5	61	20	mapping	mapping	NN
cord-016293-pyb00pt5	61	21	and	and	CC
cord-016293-pyb00pt5	61	22	sequencing	sequencing	NN
cord-016293-pyb00pt5	61	23	and	and	CC
cord-016293-pyb00pt5	61	24	subsequently	subsequently	RB
cord-016293-pyb00pt5	61	25	spurred	spur	VBD
cord-016293-pyb00pt5	61	26	on	on	IN
cord-016293-pyb00pt5	61	27	the	the	DT
cord-016293-pyb00pt5	61	28	development	development	NN
cord-016293-pyb00pt5	61	29	of	of	IN
cord-016293-pyb00pt5	61	30	ever	ever	RB
cord-016293-pyb00pt5	61	31	more	more	RBR
cord-016293-pyb00pt5	61	32	efficient	efficient	JJ
cord-016293-pyb00pt5	61	33	tools	tool	NNS
cord-016293-pyb00pt5	61	34	and	and	CC
cord-016293-pyb00pt5	61	35	techniques	technique	NNS
cord-016293-pyb00pt5	61	36	.	.	.
cord-016293-pyb00pt5	62	1	Advances	advance	NNS
cord-016293-pyb00pt5	62	2	in	in	IN
cord-016293-pyb00pt5	62	3	analytical	analytical	JJ
cord-016293-pyb00pt5	62	4	tools	tool	NNS
cord-016293-pyb00pt5	62	5	,	,	,
cord-016293-pyb00pt5	62	6	automation	automation	NN
cord-016293-pyb00pt5	62	7	,	,	,
cord-016293-pyb00pt5	62	8	and	and	CC
cord-016293-pyb00pt5	62	9	chemistries	chemistry	NNS
cord-016293-pyb00pt5	62	10	as	as	RB
cord-016293-pyb00pt5	62	11	well	well	RB
cord-016293-pyb00pt5	62	12	as	as	IN
cord-016293-pyb00pt5	62	13	computational	computational	JJ
cord-016293-pyb00pt5	62	14	power	power	NN
cord-016293-pyb00pt5	62	15	and	and	CC
cord-016293-pyb00pt5	62	16	algorithms	algorithm	NNS
cord-016293-pyb00pt5	62	17	revolutionized	revolutionize	VBD
cord-016293-pyb00pt5	62	18	the	the	DT
cord-016293-pyb00pt5	62	19	ability	ability	NN
cord-016293-pyb00pt5	62	20	to	to	TO
cord-016293-pyb00pt5	62	21	generate	generate	VB
cord-016293-pyb00pt5	62	22	and	and	CC
cord-016293-pyb00pt5	62	23	analyze	analyze	VB
cord-016293-pyb00pt5	62	24	immense	immense	JJ
cord-016293-pyb00pt5	62	25	amounts	amount	NNS
cord-016293-pyb00pt5	62	26	of	of	IN
cord-016293-pyb00pt5	62	27	DNA	dna	NN
cord-016293-pyb00pt5	62	28	sequence	sequence	NN
cord-016293-pyb00pt5	62	29	and	and	CC
cord-016293-pyb00pt5	62	30	genotype	genotype	NN
cord-016293-pyb00pt5	62	31	information	information	NN
cord-016293-pyb00pt5	62	32	.	.	.
cord-016293-pyb00pt5	63	1	In	in	IN
cord-016293-pyb00pt5	63	2	addition	addition	NN
cord-016293-pyb00pt5	63	3	to	to	IN
cord-016293-pyb00pt5	63	4	leading	lead	VBG
cord-016293-pyb00pt5	63	5	to	to	IN
cord-016293-pyb00pt5	63	6	the	the	DT
cord-016293-pyb00pt5	63	7	determination	determination	NN
cord-016293-pyb00pt5	63	8	of	of	IN
cord-016293-pyb00pt5	63	9	the	the	DT
cord-016293-pyb00pt5	63	10	complete	complete	JJ
cord-016293-pyb00pt5	63	11	sequences	sequence	NNS
cord-016293-pyb00pt5	63	12	of	of	IN
cord-016293-pyb00pt5	63	13	a	a	DT
cord-016293-pyb00pt5	63	14	variety	variety	NN
cord-016293-pyb00pt5	63	15	of	of	IN
cord-016293-pyb00pt5	63	16	microorganisms	microorganism	NNS
cord-016293-pyb00pt5	63	17	and	and	CC
cord-016293-pyb00pt5	63	18	a	a	DT
cord-016293-pyb00pt5	63	19	rapidly	rapidly	RB
cord-016293-pyb00pt5	63	20	increasing	increase	VBG
cord-016293-pyb00pt5	63	21	number	number	NN
cord-016293-pyb00pt5	63	22	of	of	IN
cord-016293-pyb00pt5	63	23	model	model	NN
cord-016293-pyb00pt5	63	24	organisms	organism	NNS
cord-016293-pyb00pt5	63	25	,	,	,
cord-016293-pyb00pt5	63	26	these	these	DT
cord-016293-pyb00pt5	63	27	technologies	technology	NNS
cord-016293-pyb00pt5	63	28	have	have	VBP
cord-016293-pyb00pt5	63	29	provided	provide	VBN
cord-016293-pyb00pt5	63	30	insights	insight	NNS
cord-016293-pyb00pt5	63	31	into	into	IN
cord-016293-pyb00pt5	63	32	the	the	DT
cord-016293-pyb00pt5	63	33	repertoire	repertoire	NN
cord-016293-pyb00pt5	63	34	of	of	IN
cord-016293-pyb00pt5	63	35	genes	gene	NNS
cord-016293-pyb00pt5	63	36	that	that	WDT
cord-016293-pyb00pt5	63	37	are	be	VBP
cord-016293-pyb00pt5	63	38	required	require	VBN
cord-016293-pyb00pt5	63	39	for	for	IN
cord-016293-pyb00pt5	63	40	life	life	NN
cord-016293-pyb00pt5	63	41	,	,	,
cord-016293-pyb00pt5	63	42	and	and	CC
cord-016293-pyb00pt5	63	43	their	-PRON-	PRP$
cord-016293-pyb00pt5	63	44	allelic	allelic	JJ
cord-016293-pyb00pt5	63	45	diversity	diversity	NN
cord-016293-pyb00pt5	63	46	as	as	RB
cord-016293-pyb00pt5	63	47	well	well	RB
cord-016293-pyb00pt5	63	48	as	as	IN
cord-016293-pyb00pt5	63	49	their	-PRON-	PRP$
cord-016293-pyb00pt5	63	50	organization	organization	NN
cord-016293-pyb00pt5	63	51	in	in	IN
cord-016293-pyb00pt5	63	52	the	the	DT
cord-016293-pyb00pt5	63	53	genome	genome	NN
cord-016293-pyb00pt5	63	54	.	.	.
cord-016293-pyb00pt5	64	1	But	but	CC
cord-016293-pyb00pt5	64	2	back	back	RB
cord-016293-pyb00pt5	64	3	in	in	IN
cord-016293-pyb00pt5	64	4	1990	1990	CD
cord-016293-pyb00pt5	64	5	many	many	JJ
cord-016293-pyb00pt5	64	6	of	of	IN
cord-016293-pyb00pt5	64	7	these	these	DT
cord-016293-pyb00pt5	64	8	were	be	VBD
cord-016293-pyb00pt5	64	9	still	still	RB
cord-016293-pyb00pt5	64	10	nascent	nascent	JJ
cord-016293-pyb00pt5	64	11	technologies	technology	NNS
cord-016293-pyb00pt5	64	12	.	.	.
cord-016293-pyb00pt5	65	1	The	the	DT
cord-016293-pyb00pt5	65	2	technologies	technology	NNS
cord-016293-pyb00pt5	65	3	required	require	VBN
cord-016293-pyb00pt5	65	4	to	to	TO
cord-016293-pyb00pt5	65	5	achieve	achieve	VB
cord-016293-pyb00pt5	65	6	this	this	DT
cord-016293-pyb00pt5	65	7	end	end	NN
cord-016293-pyb00pt5	65	8	could	could	MD
cord-016293-pyb00pt5	65	9	be	be	VB
cord-016293-pyb00pt5	65	10	broadly	broadly	RB
cord-016293-pyb00pt5	65	11	divided	divide	VBN
cord-016293-pyb00pt5	65	12	into	into	IN
cord-016293-pyb00pt5	65	13	three	three	CD
cord-016293-pyb00pt5	65	14	categories	category	NNS
cord-016293-pyb00pt5	65	15	:	:	:
cord-016293-pyb00pt5	65	16	equipment	equipment	NN
cord-016293-pyb00pt5	65	17	,	,	,
cord-016293-pyb00pt5	65	18	techniques	technique	NNS
cord-016293-pyb00pt5	65	19	,	,	,
cord-016293-pyb00pt5	65	20	and	and	CC
cord-016293-pyb00pt5	65	21	computational	computational	JJ
cord-016293-pyb00pt5	65	22	analysis	analysis	NN
cord-016293-pyb00pt5	65	23	.	.	.
cord-016293-pyb00pt5	66	1	These	these	DT
cord-016293-pyb00pt5	66	2	are	be	VBP
cord-016293-pyb00pt5	66	3	not	not	RB
cord-016293-pyb00pt5	66	4	truly	truly	RB
cord-016293-pyb00pt5	66	5	discrete	discrete	JJ
cord-016293-pyb00pt5	66	6	divisions	division	NNS
cord-016293-pyb00pt5	66	7	and	and	CC
cord-016293-pyb00pt5	66	8	there	there	EX
cord-016293-pyb00pt5	66	9	was	be	VBD
cord-016293-pyb00pt5	66	10	much	much	JJ
cord-016293-pyb00pt5	66	11	overlap	overlap	NN
cord-016293-pyb00pt5	66	12	in	in	IN
cord-016293-pyb00pt5	66	13	their	-PRON-	PRP$
cord-016293-pyb00pt5	66	14	influence	influence	NN
cord-016293-pyb00pt5	66	15	on	on	IN
cord-016293-pyb00pt5	66	16	each	each	DT
cord-016293-pyb00pt5	66	17	other	other	JJ
cord-016293-pyb00pt5	66	18	.	.	.
cord-016293-pyb00pt5	67	1	As	as	IN
cord-016293-pyb00pt5	67	2	noted	note	VBN
cord-016293-pyb00pt5	67	3	,	,	,
cord-016293-pyb00pt5	67	4	Lloyd	Lloyd	NNP
cord-016293-pyb00pt5	67	5	Smith	Smith	NNP
cord-016293-pyb00pt5	67	6	,	,	,
cord-016293-pyb00pt5	67	7	Michael	Michael	NNP
cord-016293-pyb00pt5	67	8	and	and	CC
cord-016293-pyb00pt5	67	9	Tim	Tim	NNP
cord-016293-pyb00pt5	67	10	Hunkapiller	Hunkapiller	NNP
cord-016293-pyb00pt5	67	11	,	,	,
cord-016293-pyb00pt5	67	12	and	and	CC
cord-016293-pyb00pt5	67	13	Leroy	Leroy	NNP
cord-016293-pyb00pt5	67	14	Hood	Hood	NNP
cord-016293-pyb00pt5	67	15	conceived	conceive	VBD
cord-016293-pyb00pt5	67	16	the	the	DT
cord-016293-pyb00pt5	67	17	automated	automate	VBN
cord-016293-pyb00pt5	67	18	sequencer	sequencer	NN
cord-016293-pyb00pt5	67	19	and	and	CC
cord-016293-pyb00pt5	67	20	Applied	Applied	NNP
cord-016293-pyb00pt5	67	21	Biosystems	Biosystems	NNP
cord-016293-pyb00pt5	67	22	Inc.	Inc.	NNP
cord-016293-pyb00pt5	67	23	brought	bring	VBD
cord-016293-pyb00pt5	67	24	it	-PRON-	PRP
cord-016293-pyb00pt5	67	25	to	to	IN
cord-016293-pyb00pt5	67	26	market	market	NN
cord-016293-pyb00pt5	67	27	in	in	IN
cord-016293-pyb00pt5	67	28	June	June	NNP
cord-016293-pyb00pt5	67	29	1986	1986	CD
cord-016293-pyb00pt5	67	30	.	.	.
cord-016293-pyb00pt5	68	1	There	there	EX
cord-016293-pyb00pt5	68	2	is	be	VBZ
cord-016293-pyb00pt5	68	3	no	no	DT
cord-016293-pyb00pt5	68	4	much	much	JJ
cord-016293-pyb00pt5	68	5	doubt	doubt	NN
cord-016293-pyb00pt5	68	6	that	that	IN
cord-016293-pyb00pt5	68	7	when	when	WRB
cord-016293-pyb00pt5	68	8	Applied	Applied	NNP
cord-016293-pyb00pt5	68	9	Biosystems	Biosystems	NNP
cord-016293-pyb00pt5	68	10	Inc.	Inc.	NNP
cord-016293-pyb00pt5	68	11	put	put	VBD
cord-016293-pyb00pt5	68	12	it	-PRON-	PRP
cord-016293-pyb00pt5	68	13	on	on	IN
cord-016293-pyb00pt5	68	14	the	the	DT
cord-016293-pyb00pt5	68	15	market	market	NN
cord-016293-pyb00pt5	68	16	that	that	WDT
cord-016293-pyb00pt5	68	17	which	which	WDT
cord-016293-pyb00pt5	68	18	had	have	VBD
cord-016293-pyb00pt5	68	19	been	be	VBN
cord-016293-pyb00pt5	68	20	a	a	DT
cord-016293-pyb00pt5	68	21	dream	dream	NN
cord-016293-pyb00pt5	68	22	became	become	VBD
cord-016293-pyb00pt5	68	23	decidedly	decidedly	RB
cord-016293-pyb00pt5	68	24	closer	close	JJR
cord-016293-pyb00pt5	68	25	to	to	IN
cord-016293-pyb00pt5	68	26	an	an	DT
cord-016293-pyb00pt5	68	27	achievable	achievable	JJ
cord-016293-pyb00pt5	68	28	reality	reality	NN
cord-016293-pyb00pt5	68	29	.	.	.
cord-016293-pyb00pt5	69	1	In	in	IN
cord-016293-pyb00pt5	69	2	automating	automate	VBG
cord-016293-pyb00pt5	69	3	Sangers	Sangers	NNP
cord-016293-pyb00pt5	69	4	chain	chain	NN
cord-016293-pyb00pt5	69	5	termination	termination	NN
cord-016293-pyb00pt5	69	6	sequencing	sequencing	NN
cord-016293-pyb00pt5	69	7	system	system	NN
cord-016293-pyb00pt5	69	8	,	,	,
cord-016293-pyb00pt5	69	9	Hood	Hood	NNP
cord-016293-pyb00pt5	69	10	modified	modify	VBD
cord-016293-pyb00pt5	69	11	both	both	CC
cord-016293-pyb00pt5	69	12	the	the	DT
cord-016293-pyb00pt5	69	13	chemistry	chemistry	NN
cord-016293-pyb00pt5	69	14	and	and	CC
cord-016293-pyb00pt5	69	15	the	the	DT
cord-016293-pyb00pt5	69	16	data	data	NN
cord-016293-pyb00pt5	69	17	-	-	HYPH
cord-016293-pyb00pt5	69	18	gathering	gather	VBG
cord-016293-pyb00pt5	69	19	processes	process	NNS
cord-016293-pyb00pt5	69	20	.	.	.
cord-016293-pyb00pt5	70	1	In	in	IN
cord-016293-pyb00pt5	70	2	the	the	DT
cord-016293-pyb00pt5	70	3	sequencing	sequencing	NN
cord-016293-pyb00pt5	70	4	reaction	reaction	NN
cord-016293-pyb00pt5	70	5	itself	-PRON-	PRP
cord-016293-pyb00pt5	70	6	,	,	,
cord-016293-pyb00pt5	70	7	he	-PRON-	PRP
cord-016293-pyb00pt5	70	8	replaced	replace	VBD
cord-016293-pyb00pt5	70	9	radioactive	radioactive	JJ
cord-016293-pyb00pt5	70	10	labels	label	NNS
cord-016293-pyb00pt5	70	11	,	,	,
cord-016293-pyb00pt5	70	12	which	which	WDT
cord-016293-pyb00pt5	70	13	were	be	VBD
cord-016293-pyb00pt5	70	14	unstable	unstable	JJ
cord-016293-pyb00pt5	70	15	,	,	,
cord-016293-pyb00pt5	70	16	posed	pose	VBD
cord-016293-pyb00pt5	70	17	a	a	DT
cord-016293-pyb00pt5	70	18	health	health	NN
cord-016293-pyb00pt5	70	19	hazard	hazard	NN
cord-016293-pyb00pt5	70	20	,	,	,
cord-016293-pyb00pt5	70	21	and	and	CC
cord-016293-pyb00pt5	70	22	required	require	VBD
cord-016293-pyb00pt5	70	23	separate	separate	JJ
cord-016293-pyb00pt5	70	24	gels	gel	NNS
cord-016293-pyb00pt5	70	25	for	for	IN
cord-016293-pyb00pt5	70	26	each	each	DT
cord-016293-pyb00pt5	70	27	of	of	IN
cord-016293-pyb00pt5	70	28	the	the	DT
cord-016293-pyb00pt5	70	29	four	four	CD
cord-016293-pyb00pt5	70	30	bases	basis	NNS
cord-016293-pyb00pt5	70	31	.	.	.
cord-016293-pyb00pt5	71	1	Hood	Hood	NNP
cord-016293-pyb00pt5	71	2	developed	develop	VBD
cord-016293-pyb00pt5	71	3	chemistry	chemistry	NN
cord-016293-pyb00pt5	71	4	that	that	WDT
cord-016293-pyb00pt5	71	5	used	use	VBD
cord-016293-pyb00pt5	71	6	fluorescent	fluorescent	JJ
cord-016293-pyb00pt5	71	7	dyes	dye	NNS
cord-016293-pyb00pt5	71	8	of	of	IN
cord-016293-pyb00pt5	71	9	different	different	JJ
cord-016293-pyb00pt5	71	10	colors	color	NNS
cord-016293-pyb00pt5	71	11	for	for	IN
cord-016293-pyb00pt5	71	12	each	each	DT
cord-016293-pyb00pt5	71	13	of	of	IN
cord-016293-pyb00pt5	71	14	the	the	DT
cord-016293-pyb00pt5	71	15	four	four	CD
cord-016293-pyb00pt5	71	16	DNA	dna	NN
cord-016293-pyb00pt5	71	17	bases	basis	NNS
cord-016293-pyb00pt5	71	18	.	.	.
cord-016293-pyb00pt5	72	1	This	this	DT
cord-016293-pyb00pt5	72	2	system	system	NN
cord-016293-pyb00pt5	72	3	of	of	IN
cord-016293-pyb00pt5	72	4	"	"	``
cord-016293-pyb00pt5	72	5	color	color	NN
cord-016293-pyb00pt5	72	6	-	-	HYPH
cord-016293-pyb00pt5	72	7	coding	code	VBG
cord-016293-pyb00pt5	72	8	"	"	''
cord-016293-pyb00pt5	72	9	eliminated	eliminate	VBD
cord-016293-pyb00pt5	72	10	the	the	DT
cord-016293-pyb00pt5	72	11	need	need	NN
cord-016293-pyb00pt5	72	12	to	to	TO
cord-016293-pyb00pt5	72	13	run	run	VB
cord-016293-pyb00pt5	72	14	several	several	JJ
cord-016293-pyb00pt5	72	15	reactions	reaction	NNS
cord-016293-pyb00pt5	72	16	in	in	IN
cord-016293-pyb00pt5	72	17	overlapping	overlap	VBG
cord-016293-pyb00pt5	72	18	gels	gel	NNS
cord-016293-pyb00pt5	72	19	.	.	.
cord-016293-pyb00pt5	73	1	The	the	DT
cord-016293-pyb00pt5	73	2	fluorescent	fluorescent	NN
cord-016293-pyb00pt5	73	3	labels	label	NNS
cord-016293-pyb00pt5	73	4	addressed	address	VBD
cord-016293-pyb00pt5	73	5	another	another	DT
cord-016293-pyb00pt5	73	6	issue	issue	NN
cord-016293-pyb00pt5	73	7	which	which	WDT
cord-016293-pyb00pt5	73	8	contributed	contribute	VBD
cord-016293-pyb00pt5	73	9	to	to	IN
cord-016293-pyb00pt5	73	10	one	one	CD
cord-016293-pyb00pt5	73	11	of	of	IN
cord-016293-pyb00pt5	73	12	the	the	DT
cord-016293-pyb00pt5	73	13	major	major	JJ
cord-016293-pyb00pt5	73	14	concerns	concern	NNS
cord-016293-pyb00pt5	73	15	of	of	IN
cord-016293-pyb00pt5	73	16	sequencing	sequence	VBG
cord-016293-pyb00pt5	73	17	-data	-data	NNS
cord-016293-pyb00pt5	73	18	gathering	gathering	NN
cord-016293-pyb00pt5	73	19	.	.	.
cord-016293-pyb00pt5	74	1	Hood	hood	NN
cord-016293-pyb00pt5	74	2	integrated	integrate	VBN
cord-016293-pyb00pt5	74	3	laser	laser	NN
cord-016293-pyb00pt5	74	4	and	and	CC
cord-016293-pyb00pt5	74	5	computer	computer	NN
cord-016293-pyb00pt5	74	6	technology	technology	NN
cord-016293-pyb00pt5	74	7	,	,	,
cord-016293-pyb00pt5	74	8	eliminating	eliminate	VBG
cord-016293-pyb00pt5	74	9	the	the	DT
cord-016293-pyb00pt5	74	10	tedious	tedious	JJ
cord-016293-pyb00pt5	74	11	process	process	NN
cord-016293-pyb00pt5	74	12	of	of	IN
cord-016293-pyb00pt5	74	13	information	information	NN
cord-016293-pyb00pt5	74	14	-	-	HYPH
cord-016293-pyb00pt5	74	15	gathering	gathering	NN
cord-016293-pyb00pt5	74	16	by	by	IN
cord-016293-pyb00pt5	74	17	hand	hand	NN
cord-016293-pyb00pt5	74	18	.	.	.
cord-016293-pyb00pt5	75	1	As	as	IN
cord-016293-pyb00pt5	75	2	the	the	DT
cord-016293-pyb00pt5	75	3	fragments	fragment	NNS
cord-016293-pyb00pt5	75	4	of	of	IN
cord-016293-pyb00pt5	75	5	DNA	DNA	NNP
cord-016293-pyb00pt5	75	6	passed	pass	VBD
cord-016293-pyb00pt5	75	7	a	a	DT
cord-016293-pyb00pt5	75	8	laser	laser	NN
cord-016293-pyb00pt5	75	9	beam	beam	NN
cord-016293-pyb00pt5	75	10	on	on	IN
cord-016293-pyb00pt5	75	11	their	-PRON-	PRP$
cord-016293-pyb00pt5	75	12	way	way	NN
cord-016293-pyb00pt5	75	13	through	through	IN
cord-016293-pyb00pt5	75	14	the	the	DT
cord-016293-pyb00pt5	75	15	gel	gel	NN
cord-016293-pyb00pt5	75	16	the	the	DT
cord-016293-pyb00pt5	75	17	fluorescent	fluorescent	JJ
cord-016293-pyb00pt5	75	18	labels	label	NNS
cord-016293-pyb00pt5	75	19	were	be	VBD
cord-016293-pyb00pt5	75	20	stimulated	stimulate	VBN
cord-016293-pyb00pt5	75	21	to	to	TO
cord-016293-pyb00pt5	75	22	emit	emit	VB
cord-016293-pyb00pt5	75	23	light	light	NN
cord-016293-pyb00pt5	75	24	.	.	.
cord-016293-pyb00pt5	76	1	The	the	DT
cord-016293-pyb00pt5	76	2	emitted	emitted	JJ
cord-016293-pyb00pt5	76	3	light	light	NN
cord-016293-pyb00pt5	76	4	was	be	VBD
cord-016293-pyb00pt5	76	5	transmitted	transmit	VBN
cord-016293-pyb00pt5	76	6	by	by	IN
cord-016293-pyb00pt5	76	7	a	a	DT
cord-016293-pyb00pt5	76	8	lens	lens	NN
cord-016293-pyb00pt5	76	9	and	and	CC
cord-016293-pyb00pt5	76	10	the	the	DT
cord-016293-pyb00pt5	76	11	intensity	intensity	NN
cord-016293-pyb00pt5	76	12	and	and	CC
cord-016293-pyb00pt5	76	13	spectral	spectral	JJ
cord-016293-pyb00pt5	76	14	characteristics	characteristic	NNS
cord-016293-pyb00pt5	76	15	of	of	IN
cord-016293-pyb00pt5	76	16	the	the	DT
cord-016293-pyb00pt5	76	17	fluorescence	fluorescence	NN
cord-016293-pyb00pt5	76	18	are	be	VBP
cord-016293-pyb00pt5	76	19	measured	measure	VBN
cord-016293-pyb00pt5	76	20	by	by	IN
cord-016293-pyb00pt5	76	21	a	a	DT
cord-016293-pyb00pt5	76	22	photomultiplier	photomultiplier	NN
cord-016293-pyb00pt5	76	23	tube	tube	NN
cord-016293-pyb00pt5	76	24	and	and	CC
cord-016293-pyb00pt5	76	25	converted	convert	VBD
cord-016293-pyb00pt5	76	26	to	to	IN
cord-016293-pyb00pt5	76	27	a	a	DT
cord-016293-pyb00pt5	76	28	digital	digital	JJ
cord-016293-pyb00pt5	76	29	format	format	NN
cord-016293-pyb00pt5	76	30	that	that	WDT
cord-016293-pyb00pt5	76	31	could	could	MD
cord-016293-pyb00pt5	76	32	be	be	VB
cord-016293-pyb00pt5	76	33	read	read	VBN
cord-016293-pyb00pt5	76	34	directly	directly	RB
cord-016293-pyb00pt5	76	35	into	into	IN
cord-016293-pyb00pt5	76	36	a	a	DT
cord-016293-pyb00pt5	76	37	computer	computer	NN
cord-016293-pyb00pt5	76	38	.	.	.
cord-016293-pyb00pt5	77	1	During	during	IN
cord-016293-pyb00pt5	77	2	the	the	DT
cord-016293-pyb00pt5	77	3	next	next	JJ
cord-016293-pyb00pt5	77	4	thirteen	thirteen	CD
cord-016293-pyb00pt5	77	5	years	year	NNS
cord-016293-pyb00pt5	77	6	,	,	,
cord-016293-pyb00pt5	77	7	the	the	DT
cord-016293-pyb00pt5	77	8	machine	machine	NN
cord-016293-pyb00pt5	77	9	was	be	VBD
cord-016293-pyb00pt5	77	10	constantly	constantly	RB
cord-016293-pyb00pt5	77	11	improved	improve	VBN
cord-016293-pyb00pt5	77	12	,	,	,
cord-016293-pyb00pt5	77	13	and	and	CC
cord-016293-pyb00pt5	77	14	by	by	IN
cord-016293-pyb00pt5	77	15	1999	1999	CD
cord-016293-pyb00pt5	77	16	a	a	DT
cord-016293-pyb00pt5	77	17	fully	fully	RB
cord-016293-pyb00pt5	77	18	automated	automate	VBN
cord-016293-pyb00pt5	77	19	instrument	instrument	NN
cord-016293-pyb00pt5	77	20	could	could	MD
cord-016293-pyb00pt5	77	21	sequence	sequence	VB
cord-016293-pyb00pt5	77	22	up	up	RP
cord-016293-pyb00pt5	77	23	to	to	IN
cord-016293-pyb00pt5	77	24	150,000,000	150,000,000	CD
cord-016293-pyb00pt5	77	25	base	base	NN
cord-016293-pyb00pt5	77	26	pairs	pair	NNS
cord-016293-pyb00pt5	77	27	per	per	IN
cord-016293-pyb00pt5	77	28	year	year	NN
cord-016293-pyb00pt5	77	29	.	.	.
cord-016293-pyb00pt5	78	1	In	in	IN
cord-016293-pyb00pt5	78	2	1990	1990	CD
cord-016293-pyb00pt5	78	3	three	three	CD
cord-016293-pyb00pt5	78	4	groups	group	NNS
cord-016293-pyb00pt5	78	5	came	come	VBD
cord-016293-pyb00pt5	78	6	up	up	RP
cord-016293-pyb00pt5	78	7	with	with	IN
cord-016293-pyb00pt5	78	8	a	a	DT
cord-016293-pyb00pt5	78	9	variation	variation	NN
cord-016293-pyb00pt5	78	10	on	on	IN
cord-016293-pyb00pt5	78	11	this	this	DT
cord-016293-pyb00pt5	78	12	approach	approach	NN
cord-016293-pyb00pt5	78	13	.	.	.
cord-016293-pyb00pt5	79	1	They	-PRON-	PRP
cord-016293-pyb00pt5	79	2	developed	develop	VBD
cord-016293-pyb00pt5	79	3	what	what	WP
cord-016293-pyb00pt5	79	4	is	be	VBZ
cord-016293-pyb00pt5	79	5	termed	term	VBN
cord-016293-pyb00pt5	79	6	capillary	capillary	JJ
cord-016293-pyb00pt5	79	7	electrophoresis	electrophoresis	NN
cord-016293-pyb00pt5	79	8	,	,	,
cord-016293-pyb00pt5	79	9	one	one	CD
cord-016293-pyb00pt5	79	10	team	team	NN
cord-016293-pyb00pt5	79	11	was	be	VBD
cord-016293-pyb00pt5	79	12	led	lead	VBN
cord-016293-pyb00pt5	79	13	by	by	IN
cord-016293-pyb00pt5	79	14	Lloyd	Lloyd	NNP
cord-016293-pyb00pt5	79	15	Smith	Smith	NNP
cord-016293-pyb00pt5	79	16	(	(	-LRB-
cord-016293-pyb00pt5	79	17	Luckey	Luckey	NNP
cord-016293-pyb00pt5	79	18	,	,	,
cord-016293-pyb00pt5	79	19	1990	1990	CD
cord-016293-pyb00pt5	79	20	)	)	-RRB-
cord-016293-pyb00pt5	79	21	,	,	,
cord-016293-pyb00pt5	79	22	the	the	DT
cord-016293-pyb00pt5	79	23	second	second	JJ
cord-016293-pyb00pt5	79	24	by	by	IN
cord-016293-pyb00pt5	79	25	Barry	Barry	NNP
cord-016293-pyb00pt5	79	26	Karger	Karger	NNP
cord-016293-pyb00pt5	79	27	,	,	,
cord-016293-pyb00pt5	79	28	and	and	CC
cord-016293-pyb00pt5	79	29	the	the	DT
cord-016293-pyb00pt5	79	30	third	third	JJ
cord-016293-pyb00pt5	79	31	by	by	IN
cord-016293-pyb00pt5	79	32	Norman	Norman	NNP
cord-016293-pyb00pt5	79	33	Dovichi	Dovichi	NNP
cord-016293-pyb00pt5	79	34	.	.	.
cord-016293-pyb00pt5	80	1	In	in	IN
cord-016293-pyb00pt5	80	2	1997	1997	CD
cord-016293-pyb00pt5	80	3	Molecular	Molecular	NNP
cord-016293-pyb00pt5	80	4	Dynamics	Dynamics	NNP
cord-016293-pyb00pt5	80	5	introduced	introduce	VBD
cord-016293-pyb00pt5	80	6	the	the	DT
cord-016293-pyb00pt5	80	7	MegaBACE	MegaBACE	NNP
cord-016293-pyb00pt5	80	8	,	,	,
cord-016293-pyb00pt5	80	9	a	a	DT
cord-016293-pyb00pt5	80	10	capillary	capillary	JJ
cord-016293-pyb00pt5	80	11	sequencing	sequencing	NN
cord-016293-pyb00pt5	80	12	machine	machine	NN
cord-016293-pyb00pt5	80	13	.	.	.
cord-016293-pyb00pt5	81	1	And	and	CC
cord-016293-pyb00pt5	81	2	not	not	RB
cord-016293-pyb00pt5	81	3	to	to	TO
cord-016293-pyb00pt5	81	4	be	be	VB
cord-016293-pyb00pt5	81	5	outdone	outdo	VBN
cord-016293-pyb00pt5	81	6	the	the	DT
cord-016293-pyb00pt5	81	7	following	following	JJ
cord-016293-pyb00pt5	81	8	year	year	NN
cord-016293-pyb00pt5	81	9	in	in	IN
cord-016293-pyb00pt5	81	10	1998	1998	CD
cord-016293-pyb00pt5	82	1	,	,	,
cord-016293-pyb00pt5	82	2	the	the	DT
cord-016293-pyb00pt5	82	3	original	original	NN
cord-016293-pyb00pt5	82	4	of	of	IN
cord-016293-pyb00pt5	82	5	the	the	DT
cord-016293-pyb00pt5	82	6	species	specie	NNS
cord-016293-pyb00pt5	82	7	came	come	VBD
cord-016293-pyb00pt5	82	8	up	up	RP
cord-016293-pyb00pt5	82	9	with	with	IN
cord-016293-pyb00pt5	82	10	the	the	DT
cord-016293-pyb00pt5	82	11	ABI	ABI	NNP
cord-016293-pyb00pt5	82	12	Prism	Prism	NNP
cord-016293-pyb00pt5	82	13	3700	3700	CD
cord-016293-pyb00pt5	82	14	sequencing	sequencing	NN
cord-016293-pyb00pt5	82	15	machine	machine	NN
cord-016293-pyb00pt5	82	16	.	.	.
cord-016293-pyb00pt5	83	1	The	the	DT
cord-016293-pyb00pt5	83	2	3700	3700	CD
cord-016293-pyb00pt5	83	3	is	be	VBZ
cord-016293-pyb00pt5	83	4	also	also	RB
cord-016293-pyb00pt5	83	5	a	a	DT
cord-016293-pyb00pt5	83	6	capillary	capillary	NN
cord-016293-pyb00pt5	83	7	-	-	HYPH
cord-016293-pyb00pt5	83	8	based	base	VBN
cord-016293-pyb00pt5	83	9	machine	machine	NN
cord-016293-pyb00pt5	83	10	designed	design	VBN
cord-016293-pyb00pt5	83	11	to	to	TO
cord-016293-pyb00pt5	83	12	run	run	VB
cord-016293-pyb00pt5	83	13	about	about	RB
cord-016293-pyb00pt5	83	14	eight	eight	CD
cord-016293-pyb00pt5	83	15	sets	set	NNS
cord-016293-pyb00pt5	83	16	of	of	IN
cord-016293-pyb00pt5	83	17	96	96	CD
cord-016293-pyb00pt5	83	18	sequence	sequence	NN
cord-016293-pyb00pt5	83	19	reactions	reaction	NNS
cord-016293-pyb00pt5	83	20	per	per	IN
cord-016293-pyb00pt5	83	21	day	day	NN
cord-016293-pyb00pt5	83	22	.	.	.
cord-016293-pyb00pt5	84	1	On	on	IN
cord-016293-pyb00pt5	84	2	the	the	DT
cord-016293-pyb00pt5	84	3	biology	biology	NN
cord-016293-pyb00pt5	84	4	side	side	NN
cord-016293-pyb00pt5	84	5	,	,	,
cord-016293-pyb00pt5	84	6	one	one	CD
cord-016293-pyb00pt5	84	7	of	of	IN
cord-016293-pyb00pt5	84	8	the	the	DT
cord-016293-pyb00pt5	84	9	biggest	big	JJS
cord-016293-pyb00pt5	84	10	challenges	challenge	NNS
cord-016293-pyb00pt5	84	11	was	be	VBD
cord-016293-pyb00pt5	84	12	the	the	DT
cord-016293-pyb00pt5	84	13	construction	construction	NN
cord-016293-pyb00pt5	84	14	of	of	IN
cord-016293-pyb00pt5	84	15	a	a	DT
cord-016293-pyb00pt5	84	16	physical	physical	JJ
cord-016293-pyb00pt5	84	17	map	map	NN
cord-016293-pyb00pt5	84	18	to	to	TO
cord-016293-pyb00pt5	84	19	be	be	VB
cord-016293-pyb00pt5	84	20	compiled	compile	VBN
cord-016293-pyb00pt5	84	21	from	from	IN
cord-016293-pyb00pt5	84	22	many	many	JJ
cord-016293-pyb00pt5	84	23	diverse	diverse	JJ
cord-016293-pyb00pt5	84	24	sources	source	NNS
cord-016293-pyb00pt5	84	25	and	and	CC
cord-016293-pyb00pt5	84	26	approaches	approach	NNS
cord-016293-pyb00pt5	84	27	in	in	IN
cord-016293-pyb00pt5	84	28	such	such	PDT
cord-016293-pyb00pt5	84	29	a	a	DT
cord-016293-pyb00pt5	84	30	way	way	NN
cord-016293-pyb00pt5	84	31	as	as	IN
cord-016293-pyb00pt5	84	32	to	to	TO
cord-016293-pyb00pt5	84	33	insure	insure	VB
cord-016293-pyb00pt5	84	34	continuity	continuity	NN
cord-016293-pyb00pt5	84	35	of	of	IN
cord-016293-pyb00pt5	84	36	physical	physical	JJ
cord-016293-pyb00pt5	84	37	mapping	mapping	NN
cord-016293-pyb00pt5	84	38	data	datum	NNS
cord-016293-pyb00pt5	84	39	over	over	IN
cord-016293-pyb00pt5	84	40	long	long	JJ
cord-016293-pyb00pt5	84	41	stretches	stretch	NNS
cord-016293-pyb00pt5	84	42	of	of	IN
cord-016293-pyb00pt5	84	43	DNA	dna	NN
cord-016293-pyb00pt5	84	44	.	.	.
cord-016293-pyb00pt5	85	1	The	the	DT
cord-016293-pyb00pt5	85	2	development	development	NN
cord-016293-pyb00pt5	85	3	of	of	IN
cord-016293-pyb00pt5	85	4	DNA	dna	NN
cord-016293-pyb00pt5	85	5	Sequence	sequence	NN
cord-016293-pyb00pt5	85	6	Tagged	Tagged	NNP
cord-016293-pyb00pt5	85	7	Sites	Sites	NNPS
cord-016293-pyb00pt5	85	8	(	(	-LRB-
cord-016293-pyb00pt5	85	9	STSs	STSs	NNP
cord-016293-pyb00pt5	85	10	)	)	-RRB-
cord-016293-pyb00pt5	85	11	to	to	TO
cord-016293-pyb00pt5	85	12	correlate	correlate	VB
cord-016293-pyb00pt5	85	13	diverse	diverse	JJ
cord-016293-pyb00pt5	85	14	types	type	NNS
cord-016293-pyb00pt5	85	15	of	of	IN
cord-016293-pyb00pt5	85	16	DNA	dna	NN
cord-016293-pyb00pt5	85	17	clones	clone	NNS
cord-016293-pyb00pt5	85	18	aided	aid	VBD
cord-016293-pyb00pt5	85	19	this	this	DT
cord-016293-pyb00pt5	85	20	standardization	standardization	NN
cord-016293-pyb00pt5	85	21	of	of	IN
cord-016293-pyb00pt5	85	22	the	the	DT
cord-016293-pyb00pt5	85	23	mapping	mapping	NN
cord-016293-pyb00pt5	85	24	component	component	NN
cord-016293-pyb00pt5	85	25	by	by	IN
cord-016293-pyb00pt5	85	26	providing	provide	VBG
cord-016293-pyb00pt5	85	27	mappers	mapper	NNS
cord-016293-pyb00pt5	85	28	with	with	IN
cord-016293-pyb00pt5	85	29	a	a	DT
cord-016293-pyb00pt5	85	30	common	common	JJ
cord-016293-pyb00pt5	85	31	language	language	NN
cord-016293-pyb00pt5	85	32	and	and	CC
cord-016293-pyb00pt5	85	33	a	a	DT
cord-016293-pyb00pt5	85	34	system	system	NN
cord-016293-pyb00pt5	85	35	of	of	IN
cord-016293-pyb00pt5	85	36	landmarks	landmark	NNS
cord-016293-pyb00pt5	85	37	for	for	IN
cord-016293-pyb00pt5	85	38	all	all	PDT
cord-016293-pyb00pt5	85	39	the	the	DT
cord-016293-pyb00pt5	85	40	libraries	library	NNS
cord-016293-pyb00pt5	85	41	from	from	IN
cord-016293-pyb00pt5	85	42	such	such	JJ
cord-016293-pyb00pt5	85	43	varied	varied	JJ
cord-016293-pyb00pt5	85	44	sources	source	NNS
cord-016293-pyb00pt5	85	45	as	as	IN
cord-016293-pyb00pt5	85	46	cosmids	cosmid	NNS
cord-016293-pyb00pt5	85	47	,	,	,
cord-016293-pyb00pt5	85	48	yeast	yeast	NN
cord-016293-pyb00pt5	85	49	artificial	artificial	JJ
cord-016293-pyb00pt5	85	50	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	85	51	(	(	-LRB-
cord-016293-pyb00pt5	85	52	YACs	YACs	NNP
cord-016293-pyb00pt5	85	53	)	)	-RRB-
cord-016293-pyb00pt5	85	54	and	and	CC
cord-016293-pyb00pt5	85	55	other	other	JJ
cord-016293-pyb00pt5	85	56	rDNAs	rdnas	CD
cord-016293-pyb00pt5	85	57	clones	clone	NNS
cord-016293-pyb00pt5	85	58	.	.	.
cord-016293-pyb00pt5	86	1	This	this	DT
cord-016293-pyb00pt5	86	2	way	way	NN
cord-016293-pyb00pt5	86	3	each	each	DT
cord-016293-pyb00pt5	86	4	mapped	map	VBN
cord-016293-pyb00pt5	86	5	element	element	NN
cord-016293-pyb00pt5	86	6	(	(	-LRB-
cord-016293-pyb00pt5	86	7	individual	individual	JJ
cord-016293-pyb00pt5	86	8	clone	clone	NN
cord-016293-pyb00pt5	86	9	,	,	,
cord-016293-pyb00pt5	86	10	contig	contig	NN
cord-016293-pyb00pt5	86	11	,	,	,
cord-016293-pyb00pt5	86	12	or	or	CC
cord-016293-pyb00pt5	86	13	sequenced	sequence	VBN
cord-016293-pyb00pt5	86	14	region	region	NN
cord-016293-pyb00pt5	86	15	)	)	-RRB-
cord-016293-pyb00pt5	86	16	would	would	MD
cord-016293-pyb00pt5	86	17	be	be	VB
cord-016293-pyb00pt5	86	18	defined	define	VBN
cord-016293-pyb00pt5	86	19	by	by	IN
cord-016293-pyb00pt5	86	20	a	a	DT
cord-016293-pyb00pt5	86	21	unique	unique	JJ
cord-016293-pyb00pt5	86	22	STS	sts	NN
cord-016293-pyb00pt5	86	23	.	.	.
cord-016293-pyb00pt5	87	1	A	a	DT
cord-016293-pyb00pt5	87	2	crude	crude	JJ
cord-016293-pyb00pt5	87	3	map	map	NN
cord-016293-pyb00pt5	87	4	of	of	IN
cord-016293-pyb00pt5	87	5	the	the	DT
cord-016293-pyb00pt5	87	6	entire	entire	JJ
cord-016293-pyb00pt5	87	7	genome	genome	NN
cord-016293-pyb00pt5	87	8	,	,	,
cord-016293-pyb00pt5	87	9	showing	show	VBG
cord-016293-pyb00pt5	87	10	the	the	DT
cord-016293-pyb00pt5	87	11	order	order	NN
cord-016293-pyb00pt5	87	12	and	and	CC
cord-016293-pyb00pt5	87	13	spacing	spacing	NN
cord-016293-pyb00pt5	87	14	of	of	IN
cord-016293-pyb00pt5	87	15	STSs	sts	NNS
cord-016293-pyb00pt5	87	16	,	,	,
cord-016293-pyb00pt5	87	17	could	could	MD
cord-016293-pyb00pt5	87	18	then	then	RB
cord-016293-pyb00pt5	87	19	be	be	VB
cord-016293-pyb00pt5	87	20	constructed	construct	VBN
cord-016293-pyb00pt5	87	21	.	.	.
cord-016293-pyb00pt5	88	1	The	the	DT
cord-016293-pyb00pt5	88	2	order	order	NN
cord-016293-pyb00pt5	88	3	and	and	CC
cord-016293-pyb00pt5	88	4	spacing	spacing	NN
cord-016293-pyb00pt5	88	5	of	of	IN
cord-016293-pyb00pt5	88	6	these	these	DT
cord-016293-pyb00pt5	88	7	unique	unique	JJ
cord-016293-pyb00pt5	88	8	identifier	identifier	NN
cord-016293-pyb00pt5	88	9	sequences	sequence	NNS
cord-016293-pyb00pt5	88	10	composing	compose	VBG
cord-016293-pyb00pt5	88	11	an	an	DT
cord-016293-pyb00pt5	88	12	STS	sts	NN
cord-016293-pyb00pt5	88	13	map	map	NN
cord-016293-pyb00pt5	88	14	was	be	VBD
cord-016293-pyb00pt5	88	15	made	make	VBN
cord-016293-pyb00pt5	88	16	possible	possible	JJ
cord-016293-pyb00pt5	88	17	by	by	IN
cord-016293-pyb00pt5	88	18	development	development	NN
cord-016293-pyb00pt5	88	19	of	of	IN
cord-016293-pyb00pt5	88	20	Mullis	Mullis	NNP
cord-016293-pyb00pt5	88	21	'	'	POS
cord-016293-pyb00pt5	88	22	polymerase	polymerase	NN
cord-016293-pyb00pt5	88	23	chain	chain	NN
cord-016293-pyb00pt5	88	24	reaction	reaction	NN
cord-016293-pyb00pt5	88	25	(	(	-LRB-
cord-016293-pyb00pt5	88	26	PCR	PCR	NNP
cord-016293-pyb00pt5	88	27	)	)	-RRB-
cord-016293-pyb00pt5	88	28	,	,	,
cord-016293-pyb00pt5	88	29	which	which	WDT
cord-016293-pyb00pt5	88	30	allows	allow	VBZ
cord-016293-pyb00pt5	88	31	rapid	rapid	JJ
cord-016293-pyb00pt5	88	32	production	production	NN
cord-016293-pyb00pt5	88	33	of	of	IN
cord-016293-pyb00pt5	88	34	multiple	multiple	JJ
cord-016293-pyb00pt5	88	35	copies	copy	NNS
cord-016293-pyb00pt5	88	36	of	of	IN
cord-016293-pyb00pt5	88	37	a	a	DT
cord-016293-pyb00pt5	88	38	specific	specific	JJ
cord-016293-pyb00pt5	88	39	DNA	dna	NN
cord-016293-pyb00pt5	88	40	fragment	fragment	NN
cord-016293-pyb00pt5	88	41	,	,	,
cord-016293-pyb00pt5	88	42	for	for	IN
cord-016293-pyb00pt5	88	43	example	example	NN
cord-016293-pyb00pt5	88	44	,	,	,
cord-016293-pyb00pt5	88	45	an	an	DT
cord-016293-pyb00pt5	88	46	STS	sts	NN
cord-016293-pyb00pt5	88	47	fragment	fragment	NN
cord-016293-pyb00pt5	88	48	.	.	.
cord-016293-pyb00pt5	89	1	Sequence	sequence	NN
cord-016293-pyb00pt5	89	2	information	information	NN
cord-016293-pyb00pt5	89	3	generated	generate	VBN
cord-016293-pyb00pt5	89	4	in	in	IN
cord-016293-pyb00pt5	89	5	this	this	DT
cord-016293-pyb00pt5	89	6	way	way	NN
cord-016293-pyb00pt5	89	7	could	could	MD
cord-016293-pyb00pt5	89	8	be	be	VB
cord-016293-pyb00pt5	89	9	recalled	recall	VBN
cord-016293-pyb00pt5	89	10	easily	easily	RB
cord-016293-pyb00pt5	89	11	and	and	CC
cord-016293-pyb00pt5	89	12	,	,	,
cord-016293-pyb00pt5	89	13	once	once	RB
cord-016293-pyb00pt5	89	14	reported	report	VBD
cord-016293-pyb00pt5	89	15	to	to	IN
cord-016293-pyb00pt5	89	16	a	a	DT
cord-016293-pyb00pt5	89	17	database	database	NN
cord-016293-pyb00pt5	89	18	,	,	,
cord-016293-pyb00pt5	89	19	would	would	MD
cord-016293-pyb00pt5	89	20	be	be	VB
cord-016293-pyb00pt5	89	21	available	available	JJ
cord-016293-pyb00pt5	89	22	to	to	IN
cord-016293-pyb00pt5	89	23	other	other	JJ
cord-016293-pyb00pt5	89	24	investigators	investigator	NNS
cord-016293-pyb00pt5	89	25	.	.	.
cord-016293-pyb00pt5	90	1	With	with	IN
cord-016293-pyb00pt5	90	2	the	the	DT
cord-016293-pyb00pt5	90	3	STS	sts	NN
cord-016293-pyb00pt5	90	4	sequence	sequence	NN
cord-016293-pyb00pt5	90	5	stored	store	VBN
cord-016293-pyb00pt5	90	6	electronically	electronically	RB
cord-016293-pyb00pt5	90	7	,	,	,
cord-016293-pyb00pt5	90	8	there	there	EX
cord-016293-pyb00pt5	90	9	would	would	MD
cord-016293-pyb00pt5	90	10	be	be	VB
cord-016293-pyb00pt5	90	11	no	no	DT
cord-016293-pyb00pt5	90	12	need	need	NN
cord-016293-pyb00pt5	90	13	to	to	TO
cord-016293-pyb00pt5	90	14	obtain	obtain	VB
cord-016293-pyb00pt5	90	15	a	a	DT
cord-016293-pyb00pt5	90	16	probe	probe	NN
cord-016293-pyb00pt5	90	17	or	or	CC
cord-016293-pyb00pt5	90	18	any	any	DT
cord-016293-pyb00pt5	90	19	other	other	JJ
cord-016293-pyb00pt5	90	20	reagents	reagent	NNS
cord-016293-pyb00pt5	90	21	from	from	IN
cord-016293-pyb00pt5	90	22	the	the	DT
cord-016293-pyb00pt5	90	23	original	original	JJ
cord-016293-pyb00pt5	90	24	investigator	investigator	NN
cord-016293-pyb00pt5	90	25	.	.	.
cord-016293-pyb00pt5	91	1	No	no	RB
cord-016293-pyb00pt5	91	2	longer	long	RBR
cord-016293-pyb00pt5	91	3	would	would	MD
cord-016293-pyb00pt5	91	4	it	-PRON-	PRP
cord-016293-pyb00pt5	91	5	be	be	VB
cord-016293-pyb00pt5	91	6	necessary	necessary	JJ
cord-016293-pyb00pt5	91	7	to	to	TO
cord-016293-pyb00pt5	91	8	exchange	exchange	VB
cord-016293-pyb00pt5	91	9	and	and	CC
cord-016293-pyb00pt5	91	10	store	store	VB
cord-016293-pyb00pt5	91	11	hundreds	hundred	NNS
cord-016293-pyb00pt5	91	12	of	of	IN
cord-016293-pyb00pt5	91	13	thousands	thousand	NNS
cord-016293-pyb00pt5	91	14	of	of	IN
cord-016293-pyb00pt5	91	15	clones	clone	NNS
cord-016293-pyb00pt5	91	16	for	for	IN
cord-016293-pyb00pt5	91	17	full	full	JJ
cord-016293-pyb00pt5	91	18	-	-	HYPH
cord-016293-pyb00pt5	91	19	scale	scale	NN
cord-016293-pyb00pt5	91	20	sequencing	sequencing	NN
cord-016293-pyb00pt5	91	21	of	of	IN
cord-016293-pyb00pt5	91	22	the	the	DT
cord-016293-pyb00pt5	91	23	human	human	JJ
cord-016293-pyb00pt5	91	24	genome	genome	NN
cord-016293-pyb00pt5	91	25	-	-	:
cord-016293-pyb00pt5	91	26	a	a	DT
cord-016293-pyb00pt5	91	27	significant	significant	JJ
cord-016293-pyb00pt5	91	28	saving	saving	NN
cord-016293-pyb00pt5	91	29	of	of	IN
cord-016293-pyb00pt5	91	30	money	money	NN
cord-016293-pyb00pt5	91	31	,	,	,
cord-016293-pyb00pt5	91	32	effort	effort	NN
cord-016293-pyb00pt5	91	33	,	,	,
cord-016293-pyb00pt5	91	34	and	and	CC
cord-016293-pyb00pt5	91	35	time	time	NN
cord-016293-pyb00pt5	91	36	.	.	.
cord-016293-pyb00pt5	92	1	By	by	IN
cord-016293-pyb00pt5	92	2	providing	provide	VBG
cord-016293-pyb00pt5	92	3	a	a	DT
cord-016293-pyb00pt5	92	4	common	common	JJ
cord-016293-pyb00pt5	92	5	language	language	NN
cord-016293-pyb00pt5	92	6	and	and	CC
cord-016293-pyb00pt5	92	7	landmarks	landmark	NNS
cord-016293-pyb00pt5	92	8	for	for	IN
cord-016293-pyb00pt5	92	9	mapping	mapping	NN
cord-016293-pyb00pt5	92	10	,	,	,
cord-016293-pyb00pt5	92	11	STS	STS	NNP
cord-016293-pyb00pt5	92	12	's	's	POS
cord-016293-pyb00pt5	92	13	allowed	allow	VBN
cord-016293-pyb00pt5	92	14	genetic	genetic	JJ
cord-016293-pyb00pt5	92	15	and	and	CC
cord-016293-pyb00pt5	92	16	physical	physical	JJ
cord-016293-pyb00pt5	92	17	maps	map	NNS
cord-016293-pyb00pt5	92	18	to	to	TO
cord-016293-pyb00pt5	92	19	be	be	VB
cord-016293-pyb00pt5	92	20	cross	cros	VBN
cord-016293-pyb00pt5	92	21	-	-	VBN
cord-016293-pyb00pt5	92	22	referenced	reference	VBN
cord-016293-pyb00pt5	92	23	.	.	.
cord-016293-pyb00pt5	93	1	With	with	IN
cord-016293-pyb00pt5	93	2	a	a	DT
cord-016293-pyb00pt5	93	3	refinement	refinement	NN
cord-016293-pyb00pt5	93	4	on	on	IN
cord-016293-pyb00pt5	93	5	this	this	DT
cord-016293-pyb00pt5	93	6	technique	technique	NN
cord-016293-pyb00pt5	93	7	to	to	TO
cord-016293-pyb00pt5	93	8	go	go	VB
cord-016293-pyb00pt5	93	9	after	after	IN
cord-016293-pyb00pt5	93	10	actual	actual	JJ
cord-016293-pyb00pt5	93	11	genes	gene	NNS
cord-016293-pyb00pt5	93	12	,	,	,
cord-016293-pyb00pt5	93	13	Sydney	Sydney	NNP
cord-016293-pyb00pt5	93	14	Brenner	Brenner	NNP
cord-016293-pyb00pt5	93	15	proposed	propose	VBD
cord-016293-pyb00pt5	93	16	sequencing	sequencing	NN
cord-016293-pyb00pt5	93	17	human	human	NN
cord-016293-pyb00pt5	93	18	cDNAs	cdna	NNS
cord-016293-pyb00pt5	93	19	to	to	TO
cord-016293-pyb00pt5	93	20	provide	provide	VB
cord-016293-pyb00pt5	93	21	rapid	rapid	JJ
cord-016293-pyb00pt5	93	22	access	access	NN
cord-016293-pyb00pt5	93	23	to	to	IN
cord-016293-pyb00pt5	93	24	the	the	DT
cord-016293-pyb00pt5	93	25	genes	gene	NNS
cord-016293-pyb00pt5	93	26	stating	state	VBG
cord-016293-pyb00pt5	93	27	that	that	IN
cord-016293-pyb00pt5	93	28	'	'	``
cord-016293-pyb00pt5	93	29	One	one	CD
cord-016293-pyb00pt5	93	30	obvious	obvious	JJ
cord-016293-pyb00pt5	93	31	way	way	NN
cord-016293-pyb00pt5	93	32	of	of	IN
cord-016293-pyb00pt5	93	33	finding	find	VBG
cord-016293-pyb00pt5	93	34	at	at	IN
cord-016293-pyb00pt5	93	35	least	least	JJS
cord-016293-pyb00pt5	93	36	a	a	DT
cord-016293-pyb00pt5	93	37	large	large	JJ
cord-016293-pyb00pt5	93	38	part	part	NN
cord-016293-pyb00pt5	93	39	of	of	IN
cord-016293-pyb00pt5	93	40	the	the	DT
cord-016293-pyb00pt5	93	41	important	important	JJ
cord-016293-pyb00pt5	93	42	[	[	-LRB-
cord-016293-pyb00pt5	93	43	fraction	fraction	NN
cord-016293-pyb00pt5	93	44	]	]	-RRB-
cord-016293-pyb00pt5	93	45	of	of	IN
cord-016293-pyb00pt5	93	46	the	the	DT
cord-016293-pyb00pt5	93	47	human	human	JJ
cord-016293-pyb00pt5	93	48	genome	genome	NN
cord-016293-pyb00pt5	93	49	is	be	VBZ
cord-016293-pyb00pt5	93	50	to	to	TO
cord-016293-pyb00pt5	93	51	look	look	VB
cord-016293-pyb00pt5	93	52	at	at	IN
cord-016293-pyb00pt5	93	53	the	the	DT
cord-016293-pyb00pt5	93	54	sequences	sequence	NNS
cord-016293-pyb00pt5	93	55	of	of	IN
cord-016293-pyb00pt5	93	56	the	the	DT
cord-016293-pyb00pt5	93	57	messenger	messenger	NN
cord-016293-pyb00pt5	93	58	RNA	RNA	NNP
cord-016293-pyb00pt5	93	59	's	's	POS
cord-016293-pyb00pt5	93	60	of	of	IN
cord-016293-pyb00pt5	93	61	expressed	express	VBN
cord-016293-pyb00pt5	93	62	genes	gene	NNS
cord-016293-pyb00pt5	93	63	'	'	POS
cord-016293-pyb00pt5	93	64	(	(	-LRB-
cord-016293-pyb00pt5	93	65	Brenner	Brenner	NNP
cord-016293-pyb00pt5	93	66	,	,	,
cord-016293-pyb00pt5	93	67	1990	1990	CD
cord-016293-pyb00pt5	93	68	)	)	-RRB-
cord-016293-pyb00pt5	93	69	.	.	.
cord-016293-pyb00pt5	94	1	The	the	DT
cord-016293-pyb00pt5	94	2	following	following	JJ
cord-016293-pyb00pt5	94	3	year	year	NN
cord-016293-pyb00pt5	94	4	the	the	DT
cord-016293-pyb00pt5	94	5	man	man	NN
cord-016293-pyb00pt5	94	6	who	who	WP
cord-016293-pyb00pt5	94	7	was	be	VBD
cord-016293-pyb00pt5	94	8	to	to	TO
cord-016293-pyb00pt5	94	9	play	play	VB
cord-016293-pyb00pt5	94	10	a	a	DT
cord-016293-pyb00pt5	94	11	pivotal	pivotal	JJ
cord-016293-pyb00pt5	94	12	role	role	NN
cord-016293-pyb00pt5	94	13	on	on	IN
cord-016293-pyb00pt5	94	14	the	the	DT
cord-016293-pyb00pt5	94	15	world	world	NN
cord-016293-pyb00pt5	94	16	stage	stage	NN
cord-016293-pyb00pt5	94	17	that	that	WDT
cord-016293-pyb00pt5	94	18	became	become	VBD
cord-016293-pyb00pt5	94	19	the	the	DT
cord-016293-pyb00pt5	94	20	human	human	JJ
cord-016293-pyb00pt5	94	21	genome	genome	NN
cord-016293-pyb00pt5	94	22	project	project	NN
cord-016293-pyb00pt5	94	23	suggested	suggest	VBD
cord-016293-pyb00pt5	94	24	a	a	DT
cord-016293-pyb00pt5	94	25	way	way	NN
cord-016293-pyb00pt5	94	26	to	to	TO
cord-016293-pyb00pt5	94	27	implement	implement	VB
cord-016293-pyb00pt5	94	28	Sydney	Sydney	NNP
cord-016293-pyb00pt5	94	29	's	's	POS
cord-016293-pyb00pt5	94	30	approach	approach	NN
cord-016293-pyb00pt5	94	31	.	.	.
cord-016293-pyb00pt5	95	1	That	that	DT
cord-016293-pyb00pt5	95	2	player	player	NN
cord-016293-pyb00pt5	95	3	,	,	,
cord-016293-pyb00pt5	95	4	NIH	NIH	NNP
cord-016293-pyb00pt5	95	5	biologist	biologist	NN
cord-016293-pyb00pt5	95	6	J.	J.	NNP
cord-016293-pyb00pt5	95	7	Craig	Craig	NNP
cord-016293-pyb00pt5	95	8	Venter	Venter	NNP
cord-016293-pyb00pt5	95	9	announced	announce	VBD
cord-016293-pyb00pt5	95	10	a	a	DT
cord-016293-pyb00pt5	95	11	strategy	strategy	NN
cord-016293-pyb00pt5	95	12	to	to	TO
cord-016293-pyb00pt5	95	13	find	find	VB
cord-016293-pyb00pt5	95	14	expressed	express	VBN
cord-016293-pyb00pt5	95	15	genes	gene	NNS
cord-016293-pyb00pt5	95	16	,	,	,
cord-016293-pyb00pt5	95	17	using	use	VBG
cord-016293-pyb00pt5	95	18	ESTs	ESTs	NNP
cord-016293-pyb00pt5	95	19	(	(	-LRB-
cord-016293-pyb00pt5	95	20	Expressed	express	VBN
cord-016293-pyb00pt5	95	21	Sequence	sequence	NN
cord-016293-pyb00pt5	95	22	Tag	tag	NN
cord-016293-pyb00pt5	95	23	)	)	-RRB-
cord-016293-pyb00pt5	95	24	(	(	-LRB-
cord-016293-pyb00pt5	95	25	Adams	Adams	NNP
cord-016293-pyb00pt5	95	26	,	,	,
cord-016293-pyb00pt5	95	27	1991	1991	CD
cord-016293-pyb00pt5	95	28	)	)	-RRB-
cord-016293-pyb00pt5	95	29	.	.	.
cord-016293-pyb00pt5	96	1	These	these	DT
cord-016293-pyb00pt5	96	2	so	so	RB
cord-016293-pyb00pt5	96	3	called	call	VBN
cord-016293-pyb00pt5	96	4	ESTs	ESTs	NNP
cord-016293-pyb00pt5	96	5	represent	represent	VBP
cord-016293-pyb00pt5	96	6	a	a	DT
cord-016293-pyb00pt5	96	7	unique	unique	JJ
cord-016293-pyb00pt5	96	8	stretch	stretch	NN
cord-016293-pyb00pt5	96	9	of	of	IN
cord-016293-pyb00pt5	96	10	DNA	dna	NN
cord-016293-pyb00pt5	96	11	within	within	IN
cord-016293-pyb00pt5	96	12	a	a	DT
cord-016293-pyb00pt5	96	13	coding	code	VBG
cord-016293-pyb00pt5	96	14	region	region	NN
cord-016293-pyb00pt5	96	15	of	of	IN
cord-016293-pyb00pt5	96	16	a	a	DT
cord-016293-pyb00pt5	96	17	gene	gene	NN
cord-016293-pyb00pt5	96	18	,	,	,
cord-016293-pyb00pt5	96	19	which	which	WDT
cord-016293-pyb00pt5	96	20	as	as	IN
cord-016293-pyb00pt5	96	21	Sydney	Sydney	NNP
cord-016293-pyb00pt5	96	22	suggested	suggest	VBD
cord-016293-pyb00pt5	96	23	would	would	MD
cord-016293-pyb00pt5	96	24	be	be	VB
cord-016293-pyb00pt5	96	25	useful	useful	JJ
cord-016293-pyb00pt5	96	26	for	for	IN
cord-016293-pyb00pt5	96	27	identifying	identify	VBG
cord-016293-pyb00pt5	96	28	full	full	JJ
cord-016293-pyb00pt5	96	29	-	-	HYPH
cord-016293-pyb00pt5	96	30	length	length	NN
cord-016293-pyb00pt5	96	31	genes	gene	NNS
cord-016293-pyb00pt5	96	32	and	and	CC
cord-016293-pyb00pt5	96	33	as	as	IN
cord-016293-pyb00pt5	96	34	a	a	DT
cord-016293-pyb00pt5	96	35	landmark	landmark	NN
cord-016293-pyb00pt5	96	36	for	for	IN
cord-016293-pyb00pt5	96	37	mapping	mapping	NN
cord-016293-pyb00pt5	96	38	.	.	.
cord-016293-pyb00pt5	97	1	So	so	CC
cord-016293-pyb00pt5	97	2	using	use	VBG
cord-016293-pyb00pt5	97	3	this	this	DT
cord-016293-pyb00pt5	97	4	approach	approach	NN
cord-016293-pyb00pt5	97	5	projects	project	NNS
cord-016293-pyb00pt5	97	6	were	be	VBD
cord-016293-pyb00pt5	97	7	begun	begin	VBN
cord-016293-pyb00pt5	97	8	to	to	TO
cord-016293-pyb00pt5	97	9	mark	mark	VB
cord-016293-pyb00pt5	97	10	gene	gene	NN
cord-016293-pyb00pt5	97	11	sites	site	NNS
cord-016293-pyb00pt5	97	12	on	on	IN
cord-016293-pyb00pt5	97	13	chromosome	chromosome	NN
cord-016293-pyb00pt5	97	14	maps	map	NNS
cord-016293-pyb00pt5	97	15	as	as	IN
cord-016293-pyb00pt5	97	16	sites	site	NNS
cord-016293-pyb00pt5	97	17	of	of	IN
cord-016293-pyb00pt5	97	18	mRNA	mRNA	NNP
cord-016293-pyb00pt5	97	19	expression	expression	NN
cord-016293-pyb00pt5	97	20	.	.	.
cord-016293-pyb00pt5	98	1	To	to	TO
cord-016293-pyb00pt5	98	2	help	help	VB
cord-016293-pyb00pt5	98	3	with	with	IN
cord-016293-pyb00pt5	98	4	this	this	DT
cord-016293-pyb00pt5	98	5	a	a	DT
cord-016293-pyb00pt5	98	6	more	more	RBR
cord-016293-pyb00pt5	98	7	efficient	efficient	JJ
cord-016293-pyb00pt5	98	8	method	method	NN
cord-016293-pyb00pt5	98	9	of	of	IN
cord-016293-pyb00pt5	98	10	handling	handle	VBG
cord-016293-pyb00pt5	98	11	large	large	JJ
cord-016293-pyb00pt5	98	12	chunks	chunk	NNS
cord-016293-pyb00pt5	98	13	of	of	IN
cord-016293-pyb00pt5	98	14	sequences	sequence	NNS
cord-016293-pyb00pt5	98	15	was	be	VBD
cord-016293-pyb00pt5	98	16	needed	need	VBN
cord-016293-pyb00pt5	98	17	and	and	CC
cord-016293-pyb00pt5	98	18	two	two	CD
cord-016293-pyb00pt5	98	19	approaches	approach	NNS
cord-016293-pyb00pt5	98	20	were	be	VBD
cord-016293-pyb00pt5	98	21	developed	develop	VBN
cord-016293-pyb00pt5	98	22	.	.	.
cord-016293-pyb00pt5	99	1	Yeast	yeast	NN
cord-016293-pyb00pt5	99	2	artificial	artificial	JJ
cord-016293-pyb00pt5	99	3	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	99	4	,	,	,
cord-016293-pyb00pt5	99	5	which	which	WDT
cord-016293-pyb00pt5	99	6	were	be	VBD
cord-016293-pyb00pt5	99	7	developed	develop	VBN
cord-016293-pyb00pt5	99	8	by	by	IN
cord-016293-pyb00pt5	99	9	David	David	NNP
cord-016293-pyb00pt5	99	10	Burke	Burke	NNP
cord-016293-pyb00pt5	99	11	,	,	,
cord-016293-pyb00pt5	99	12	Maynard	Maynard	NNP
cord-016293-pyb00pt5	99	13	Olson	Olson	NNP
cord-016293-pyb00pt5	99	14	,	,	,
cord-016293-pyb00pt5	99	15	and	and	CC
cord-016293-pyb00pt5	99	16	George	George	NNP
cord-016293-pyb00pt5	99	17	Carle	Carle	NNP
cord-016293-pyb00pt5	99	18	,	,	,
cord-016293-pyb00pt5	99	19	increased	increase	VBD
cord-016293-pyb00pt5	99	20	insert	insert	NN
cord-016293-pyb00pt5	99	21	size	size	NN
cord-016293-pyb00pt5	99	22	10-fold	10-fold	JJ
cord-016293-pyb00pt5	100	1	(	(	-LRB-
cord-016293-pyb00pt5	100	2	David	David	NNP
cord-016293-pyb00pt5	100	3	T.	T.	NNP
cord-016293-pyb00pt5	100	4	Burke	Burke	NNP
cord-016293-pyb00pt5	100	5	et	et	NNP
cord-016293-pyb00pt5	100	6	al	al	NNP
cord-016293-pyb00pt5	100	7	.	.	NNP
cord-016293-pyb00pt5	100	8	,	,	,
cord-016293-pyb00pt5	100	9	1987	1987	CD
cord-016293-pyb00pt5	100	10	)	)	-RRB-
cord-016293-pyb00pt5	100	11	.	.	.
cord-016293-pyb00pt5	101	1	Caltech	Caltech	NNP
cord-016293-pyb00pt5	101	2	's	's	POS
cord-016293-pyb00pt5	101	3	second	second	JJ
cord-016293-pyb00pt5	101	4	major	major	JJ
cord-016293-pyb00pt5	101	5	contribution	contribution	NN
cord-016293-pyb00pt5	101	6	to	to	IN
cord-016293-pyb00pt5	101	7	the	the	DT
cord-016293-pyb00pt5	101	8	genome	genome	NN
cord-016293-pyb00pt5	101	9	project	project	NN
cord-016293-pyb00pt5	101	10	was	be	VBD
cord-016293-pyb00pt5	101	11	developed	develop	VBN
cord-016293-pyb00pt5	101	12	by	by	IN
cord-016293-pyb00pt5	101	13	Melvin	Melvin	NNP
cord-016293-pyb00pt5	101	14	Simon	Simon	NNP
cord-016293-pyb00pt5	101	15	,	,	,
cord-016293-pyb00pt5	101	16	and	and	CC
cord-016293-pyb00pt5	101	17	Hiroaki	Hiroaki	NNP
cord-016293-pyb00pt5	101	18	Shizuya	Shizuya	NNP
cord-016293-pyb00pt5	101	19	.	.	.
cord-016293-pyb00pt5	102	1	Their	-PRON-	PRP$
cord-016293-pyb00pt5	102	2	approach	approach	NN
cord-016293-pyb00pt5	102	3	to	to	IN
cord-016293-pyb00pt5	102	4	handling	handle	VBG
cord-016293-pyb00pt5	102	5	large	large	JJ
cord-016293-pyb00pt5	102	6	DNA	dna	NN
cord-016293-pyb00pt5	102	7	segments	segment	NNS
cord-016293-pyb00pt5	102	8	was	be	VBD
cord-016293-pyb00pt5	102	9	to	to	TO
cord-016293-pyb00pt5	102	10	develop	develop	VB
cord-016293-pyb00pt5	102	11	"	"	``
cord-016293-pyb00pt5	102	12	bacterial	bacterial	JJ
cord-016293-pyb00pt5	102	13	artificial	artificial	JJ
cord-016293-pyb00pt5	102	14	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	102	15	"	"	''
cord-016293-pyb00pt5	102	16	(	(	-LRB-
cord-016293-pyb00pt5	102	17	BACs	BACs	NNP
cord-016293-pyb00pt5	102	18	)	)	-RRB-
cord-016293-pyb00pt5	102	19	,	,	,
cord-016293-pyb00pt5	102	20	which	which	WDT
cord-016293-pyb00pt5	102	21	basically	basically	RB
cord-016293-pyb00pt5	102	22	allow	allow	VBP
cord-016293-pyb00pt5	102	23	bacteria	bacteria	NNS
cord-016293-pyb00pt5	102	24	to	to	TO
cord-016293-pyb00pt5	102	25	replicate	replicate	VB
cord-016293-pyb00pt5	102	26	chunks	chunk	NNS
cord-016293-pyb00pt5	102	27	greater	great	JJR
cord-016293-pyb00pt5	102	28	than	than	IN
cord-016293-pyb00pt5	102	29	100,000	100,000	CD
cord-016293-pyb00pt5	102	30	base	base	NN
cord-016293-pyb00pt5	102	31	pairs	pair	NNS
cord-016293-pyb00pt5	102	32	in	in	IN
cord-016293-pyb00pt5	102	33	length	length	NN
cord-016293-pyb00pt5	102	34	.	.	.
cord-016293-pyb00pt5	103	1	This	this	DT
cord-016293-pyb00pt5	103	2	efficient	efficient	JJ
cord-016293-pyb00pt5	103	3	production	production	NN
cord-016293-pyb00pt5	103	4	of	of	IN
cord-016293-pyb00pt5	103	5	more	more	RBR
cord-016293-pyb00pt5	103	6	stable	stable	JJ
cord-016293-pyb00pt5	103	7	,	,	,
cord-016293-pyb00pt5	103	8	large	large	JJ
cord-016293-pyb00pt5	103	9	-	-	HYPH
cord-016293-pyb00pt5	103	10	insert	insert	NN
cord-016293-pyb00pt5	103	11	BACs	bac	NNS
cord-016293-pyb00pt5	103	12	made	make	VBD
cord-016293-pyb00pt5	103	13	the	the	DT
cord-016293-pyb00pt5	103	14	latter	latter	JJ
cord-016293-pyb00pt5	103	15	an	an	DT
cord-016293-pyb00pt5	103	16	even	even	RB
cord-016293-pyb00pt5	103	17	more	more	RBR
cord-016293-pyb00pt5	103	18	attractive	attractive	JJ
cord-016293-pyb00pt5	103	19	option	option	NN
cord-016293-pyb00pt5	103	20	,	,	,
cord-016293-pyb00pt5	103	21	as	as	IN
cord-016293-pyb00pt5	103	22	they	-PRON-	PRP
cord-016293-pyb00pt5	103	23	had	have	VBD
cord-016293-pyb00pt5	103	24	greater	great	JJR
cord-016293-pyb00pt5	103	25	flexibility	flexibility	NN
cord-016293-pyb00pt5	103	26	than	than	IN
cord-016293-pyb00pt5	103	27	YACs	yac	NNS
cord-016293-pyb00pt5	103	28	.	.	.
cord-016293-pyb00pt5	104	1	In	in	IN
cord-016293-pyb00pt5	104	2	1994	1994	CD
cord-016293-pyb00pt5	104	3	in	in	IN
cord-016293-pyb00pt5	104	4	a	a	DT
cord-016293-pyb00pt5	104	5	collaboration	collaboration	NN
cord-016293-pyb00pt5	104	6	that	that	WDT
cord-016293-pyb00pt5	104	7	presages	presage	VBZ
cord-016293-pyb00pt5	104	8	the	the	DT
cord-016293-pyb00pt5	104	9	SNP	SNP	NNP
cord-016293-pyb00pt5	104	10	Consortium	Consortium	NNP
cord-016293-pyb00pt5	104	11	,	,	,
cord-016293-pyb00pt5	104	12	Washington	Washington	NNP
cord-016293-pyb00pt5	104	13	University	University	NNP
cord-016293-pyb00pt5	104	14	,	,	,
cord-016293-pyb00pt5	104	15	St	St	NNP
cord-016293-pyb00pt5	104	16	Louis	Louis	NNP
cord-016293-pyb00pt5	104	17	MO	MO	NNP
cord-016293-pyb00pt5	104	18	,	,	,
cord-016293-pyb00pt5	104	19	was	be	VBD
cord-016293-pyb00pt5	104	20	funded	fund	VBN
cord-016293-pyb00pt5	104	21	by	by	IN
cord-016293-pyb00pt5	104	22	the	the	DT
cord-016293-pyb00pt5	104	23	pharmaceutical	pharmaceutical	JJ
cord-016293-pyb00pt5	104	24	company	company	NN
cord-016293-pyb00pt5	104	25	Merck	Merck	NNP
cord-016293-pyb00pt5	104	26	and	and	CC
cord-016293-pyb00pt5	104	27	the	the	DT
cord-016293-pyb00pt5	104	28	National	National	NNP
cord-016293-pyb00pt5	104	29	Cancer	Cancer	NNP
cord-016293-pyb00pt5	104	30	Institute	Institute	NNP
cord-016293-pyb00pt5	104	31	to	to	TO
cord-016293-pyb00pt5	104	32	provide	provide	VB
cord-016293-pyb00pt5	104	33	sequence	sequence	NN
cord-016293-pyb00pt5	104	34	from	from	IN
cord-016293-pyb00pt5	104	35	those	those	DT
cord-016293-pyb00pt5	104	36	ESTs	est	NNS
cord-016293-pyb00pt5	104	37	.	.	.
cord-016293-pyb00pt5	105	1	More	More	JJR
cord-016293-pyb00pt5	105	2	than	than	IN
cord-016293-pyb00pt5	105	3	half	half	PDT
cord-016293-pyb00pt5	105	4	a	a	DT
cord-016293-pyb00pt5	105	5	million	million	CD
cord-016293-pyb00pt5	105	6	ESTs	est	NNS
cord-016293-pyb00pt5	105	7	were	be	VBD
cord-016293-pyb00pt5	105	8	submitted	submit	VBN
cord-016293-pyb00pt5	105	9	during	during	IN
cord-016293-pyb00pt5	105	10	the	the	DT
cord-016293-pyb00pt5	105	11	project	project	NN
cord-016293-pyb00pt5	105	12	(	(	-LRB-
cord-016293-pyb00pt5	105	13	Murr	Murr	NNP
cord-016293-pyb00pt5	105	14	L	L	NNP
cord-016293-pyb00pt5	105	15	et	et	NNP
cord-016293-pyb00pt5	105	16	al	al	NNP
cord-016293-pyb00pt5	105	17	.	.	NNP
cord-016293-pyb00pt5	105	18	,	,	,
cord-016293-pyb00pt5	105	19	1996	1996	CD
cord-016293-pyb00pt5	105	20	)	)	-RRB-
cord-016293-pyb00pt5	105	21	.	.	.
cord-016293-pyb00pt5	106	1	On	on	IN
cord-016293-pyb00pt5	106	2	the	the	DT
cord-016293-pyb00pt5	106	3	analysis	analysis	NN
cord-016293-pyb00pt5	106	4	side	side	NN
cord-016293-pyb00pt5	106	5	was	be	VBD
cord-016293-pyb00pt5	106	6	the	the	DT
cord-016293-pyb00pt5	106	7	major	major	JJ
cord-016293-pyb00pt5	106	8	challenge	challenge	NN
cord-016293-pyb00pt5	106	9	to	to	TO
cord-016293-pyb00pt5	106	10	manage	manage	VB
cord-016293-pyb00pt5	106	11	and	and	CC
cord-016293-pyb00pt5	106	12	mine	mine	VB
cord-016293-pyb00pt5	106	13	the	the	DT
cord-016293-pyb00pt5	106	14	vast	vast	JJ
cord-016293-pyb00pt5	106	15	amount	amount	NN
cord-016293-pyb00pt5	106	16	of	of	IN
cord-016293-pyb00pt5	106	17	DNA	dna	NN
cord-016293-pyb00pt5	106	18	sequence	sequence	NN
cord-016293-pyb00pt5	106	19	data	datum	NNS
cord-016293-pyb00pt5	106	20	being	be	VBG
cord-016293-pyb00pt5	106	21	generated	generate	VBN
cord-016293-pyb00pt5	106	22	.	.	.
cord-016293-pyb00pt5	107	1	A	a	DT
cord-016293-pyb00pt5	107	2	rate	rate	NN
cord-016293-pyb00pt5	107	3	-	-	HYPH
cord-016293-pyb00pt5	107	4	limiting	limit	VBG
cord-016293-pyb00pt5	107	5	step	step	NN
cord-016293-pyb00pt5	107	6	was	be	VBD
cord-016293-pyb00pt5	107	7	the	the	DT
cord-016293-pyb00pt5	107	8	need	need	NN
cord-016293-pyb00pt5	107	9	to	to	TO
cord-016293-pyb00pt5	107	10	develop	develop	VB
cord-016293-pyb00pt5	107	11	semi	semi	JJ
cord-016293-pyb00pt5	107	12	-	-	JJ
cord-016293-pyb00pt5	107	13	intelligent	intelligent	JJ
cord-016293-pyb00pt5	107	14	algorithms	algorithm	NNS
cord-016293-pyb00pt5	107	15	to	to	TO
cord-016293-pyb00pt5	107	16	achieve	achieve	VB
cord-016293-pyb00pt5	107	17	this	this	DT
cord-016293-pyb00pt5	107	18	Herculean	herculean	JJ
cord-016293-pyb00pt5	107	19	task	task	NN
cord-016293-pyb00pt5	107	20	.	.	.
cord-016293-pyb00pt5	108	1	This	this	DT
cord-016293-pyb00pt5	108	2	is	be	VBZ
cord-016293-pyb00pt5	108	3	where	where	WRB
cord-016293-pyb00pt5	108	4	the	the	DT
cord-016293-pyb00pt5	108	5	discipline	discipline	NN
cord-016293-pyb00pt5	108	6	of	of	IN
cord-016293-pyb00pt5	108	7	bioinformatics	bioinformatic	NNS
cord-016293-pyb00pt5	108	8	came	come	VBD
cord-016293-pyb00pt5	108	9	into	into	IN
cord-016293-pyb00pt5	108	10	play	play	NN
cord-016293-pyb00pt5	108	11	.	.	.
cord-016293-pyb00pt5	109	1	It	-PRON-	PRP
cord-016293-pyb00pt5	109	2	had	have	VBD
cord-016293-pyb00pt5	109	3	been	be	VBN
cord-016293-pyb00pt5	109	4	evolving	evolve	VBG
cord-016293-pyb00pt5	109	5	as	as	IN
cord-016293-pyb00pt5	109	6	a	a	DT
cord-016293-pyb00pt5	109	7	discipline	discipline	NN
cord-016293-pyb00pt5	109	8	since	since	IN
cord-016293-pyb00pt5	109	9	Margaret	Margaret	NNP
cord-016293-pyb00pt5	109	10	Oakley	Oakley	NNP
cord-016293-pyb00pt5	109	11	Dayhoff	Dayhoff	NNP
cord-016293-pyb00pt5	109	12	used	use	VBD
cord-016293-pyb00pt5	109	13	her	-PRON-	PRP$
cord-016293-pyb00pt5	109	14	knowledge	knowledge	NN
cord-016293-pyb00pt5	109	15	of	of	IN
cord-016293-pyb00pt5	109	16	chemistry	chemistry	NN
cord-016293-pyb00pt5	109	17	,	,	,
cord-016293-pyb00pt5	109	18	mathematics	mathematic	NNS
cord-016293-pyb00pt5	109	19	,	,	,
cord-016293-pyb00pt5	109	20	biology	biology	NN
cord-016293-pyb00pt5	109	21	and	and	CC
cord-016293-pyb00pt5	109	22	computer	computer	NN
cord-016293-pyb00pt5	109	23	science	science	NN
cord-016293-pyb00pt5	109	24	to	to	TO
cord-016293-pyb00pt5	109	25	develop	develop	VB
cord-016293-pyb00pt5	109	26	this	this	DT
cord-016293-pyb00pt5	109	27	entirely	entirely	RB
cord-016293-pyb00pt5	109	28	new	new	JJ
cord-016293-pyb00pt5	109	29	field	field	NN
cord-016293-pyb00pt5	109	30	in	in	IN
cord-016293-pyb00pt5	109	31	the	the	DT
cord-016293-pyb00pt5	109	32	early	early	JJ
cord-016293-pyb00pt5	109	33	sixties	sixty	NNS
cord-016293-pyb00pt5	109	34	.	.	.
cord-016293-pyb00pt5	110	1	She	-PRON-	PRP
cord-016293-pyb00pt5	110	2	is	be	VBZ
cord-016293-pyb00pt5	110	3	in	in	IN
cord-016293-pyb00pt5	110	4	fact	fact	NN
cord-016293-pyb00pt5	110	5	credited	credit	VBN
cord-016293-pyb00pt5	110	6	today	today	NN
cord-016293-pyb00pt5	110	7	as	as	IN
cord-016293-pyb00pt5	110	8	a	a	DT
cord-016293-pyb00pt5	110	9	founder	founder	NN
cord-016293-pyb00pt5	110	10	of	of	IN
cord-016293-pyb00pt5	110	11	the	the	DT
cord-016293-pyb00pt5	110	12	field	field	NN
cord-016293-pyb00pt5	110	13	of	of	IN
cord-016293-pyb00pt5	110	14	bioinformatics	bioinformatic	NNS
cord-016293-pyb00pt5	110	15	in	in	IN
cord-016293-pyb00pt5	110	16	which	which	WDT
cord-016293-pyb00pt5	110	17	biology	biology	NN
cord-016293-pyb00pt5	110	18	,	,	,
cord-016293-pyb00pt5	110	19	computer	computer	NN
cord-016293-pyb00pt5	110	20	science	science	NN
cord-016293-pyb00pt5	110	21	,	,	,
cord-016293-pyb00pt5	110	22	and	and	CC
cord-016293-pyb00pt5	110	23	information	information	NN
cord-016293-pyb00pt5	110	24	technology	technology	NN
cord-016293-pyb00pt5	110	25	merge	merge	VBP
cord-016293-pyb00pt5	110	26	into	into	IN
cord-016293-pyb00pt5	110	27	a	a	DT
cord-016293-pyb00pt5	110	28	single	single	JJ
cord-016293-pyb00pt5	110	29	discipline	discipline	NN
cord-016293-pyb00pt5	110	30	.	.	.
cord-016293-pyb00pt5	111	1	The	the	DT
cord-016293-pyb00pt5	111	2	ultimate	ultimate	JJ
cord-016293-pyb00pt5	111	3	goal	goal	NN
cord-016293-pyb00pt5	111	4	of	of	IN
cord-016293-pyb00pt5	111	5	the	the	DT
cord-016293-pyb00pt5	111	6	field	field	NN
cord-016293-pyb00pt5	111	7	is	be	VBZ
cord-016293-pyb00pt5	111	8	to	to	TO
cord-016293-pyb00pt5	111	9	enable	enable	VB
cord-016293-pyb00pt5	111	10	the	the	DT
cord-016293-pyb00pt5	111	11	discovery	discovery	NN
cord-016293-pyb00pt5	111	12	of	of	IN
cord-016293-pyb00pt5	111	13	new	new	JJ
cord-016293-pyb00pt5	111	14	biological	biological	JJ
cord-016293-pyb00pt5	111	15	insights	insight	NNS
cord-016293-pyb00pt5	111	16	as	as	RB
cord-016293-pyb00pt5	111	17	well	well	RB
cord-016293-pyb00pt5	111	18	as	as	IN
cord-016293-pyb00pt5	111	19	to	to	TO
cord-016293-pyb00pt5	111	20	create	create	VB
cord-016293-pyb00pt5	111	21	a	a	DT
cord-016293-pyb00pt5	111	22	global	global	JJ
cord-016293-pyb00pt5	111	23	perspective	perspective	NN
cord-016293-pyb00pt5	111	24	from	from	IN
cord-016293-pyb00pt5	111	25	which	which	WDT
cord-016293-pyb00pt5	111	26	unifying	unifying	JJ
cord-016293-pyb00pt5	111	27	principles	principle	NNS
cord-016293-pyb00pt5	111	28	in	in	IN
cord-016293-pyb00pt5	111	29	biology	biology	NN
cord-016293-pyb00pt5	111	30	can	can	MD
cord-016293-pyb00pt5	111	31	be	be	VB
cord-016293-pyb00pt5	111	32	discerned	discern	VBN
cord-016293-pyb00pt5	111	33	.	.	.
cord-016293-pyb00pt5	112	1	There	there	EX
cord-016293-pyb00pt5	112	2	are	be	VBP
cord-016293-pyb00pt5	112	3	three	three	CD
cord-016293-pyb00pt5	112	4	important	important	JJ
cord-016293-pyb00pt5	112	5	sub	sub	NN
cord-016293-pyb00pt5	112	6	-	-	NNS
cord-016293-pyb00pt5	112	7	disciplines	discipline	NNS
cord-016293-pyb00pt5	112	8	within	within	IN
cord-016293-pyb00pt5	112	9	bioinformatics	bioinformatic	NNS
cord-016293-pyb00pt5	112	10	:	:	:
cord-016293-pyb00pt5	112	11	the	the	DT
cord-016293-pyb00pt5	112	12	development	development	NN
cord-016293-pyb00pt5	112	13	of	of	IN
cord-016293-pyb00pt5	112	14	new	new	JJ
cord-016293-pyb00pt5	112	15	algorithms	algorithm	NNS
cord-016293-pyb00pt5	112	16	and	and	CC
cord-016293-pyb00pt5	112	17	statistics	statistic	NNS
cord-016293-pyb00pt5	112	18	with	with	IN
cord-016293-pyb00pt5	112	19	which	which	WDT
cord-016293-pyb00pt5	112	20	to	to	TO
cord-016293-pyb00pt5	112	21	assess	assess	VB
cord-016293-pyb00pt5	112	22	relationships	relationship	NNS
cord-016293-pyb00pt5	112	23	among	among	IN
cord-016293-pyb00pt5	112	24	members	member	NNS
cord-016293-pyb00pt5	112	25	of	of	IN
cord-016293-pyb00pt5	112	26	large	large	JJ
cord-016293-pyb00pt5	112	27	data	data	NN
cord-016293-pyb00pt5	112	28	sets	set	NNS
cord-016293-pyb00pt5	112	29	;	;	:
cord-016293-pyb00pt5	112	30	the	the	DT
cord-016293-pyb00pt5	112	31	analysis	analysis	NN
cord-016293-pyb00pt5	112	32	and	and	CC
cord-016293-pyb00pt5	112	33	interpretation	interpretation	NN
cord-016293-pyb00pt5	112	34	of	of	IN
cord-016293-pyb00pt5	112	35	various	various	JJ
cord-016293-pyb00pt5	112	36	types	type	NNS
cord-016293-pyb00pt5	112	37	of	of	IN
cord-016293-pyb00pt5	112	38	data	datum	NNS
cord-016293-pyb00pt5	112	39	including	include	VBG
cord-016293-pyb00pt5	112	40	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	112	41	and	and	CC
cord-016293-pyb00pt5	112	42	amino	amino	NN
cord-016293-pyb00pt5	112	43	acid	acid	NN
cord-016293-pyb00pt5	112	44	sequences	sequence	NNS
cord-016293-pyb00pt5	112	45	,	,	,
cord-016293-pyb00pt5	112	46	protein	protein	NN
cord-016293-pyb00pt5	112	47	domains	domain	NNS
cord-016293-pyb00pt5	112	48	,	,	,
cord-016293-pyb00pt5	112	49	and	and	CC
cord-016293-pyb00pt5	112	50	protein	protein	NN
cord-016293-pyb00pt5	112	51	structures	structure	NNS
cord-016293-pyb00pt5	112	52	;	;	:
cord-016293-pyb00pt5	112	53	and	and	CC
cord-016293-pyb00pt5	112	54	the	the	DT
cord-016293-pyb00pt5	112	55	development	development	NN
cord-016293-pyb00pt5	112	56	and	and	CC
cord-016293-pyb00pt5	112	57	implementation	implementation	NN
cord-016293-pyb00pt5	112	58	of	of	IN
cord-016293-pyb00pt5	112	59	tools	tool	NNS
cord-016293-pyb00pt5	112	60	that	that	WDT
cord-016293-pyb00pt5	112	61	enable	enable	VBP
cord-016293-pyb00pt5	112	62	efficient	efficient	JJ
cord-016293-pyb00pt5	112	63	access	access	NN
cord-016293-pyb00pt5	112	64	and	and	CC
cord-016293-pyb00pt5	112	65	management	management	NN
cord-016293-pyb00pt5	112	66	of	of	IN
cord-016293-pyb00pt5	112	67	different	different	JJ
cord-016293-pyb00pt5	112	68	types	type	NNS
cord-016293-pyb00pt5	112	69	of	of	IN
cord-016293-pyb00pt5	112	70	information	information	NN
cord-016293-pyb00pt5	112	71	.	.	.
cord-016293-pyb00pt5	113	1	Paralleling	parallel	VBG
cord-016293-pyb00pt5	113	2	the	the	DT
cord-016293-pyb00pt5	113	3	rapid	rapid	JJ
cord-016293-pyb00pt5	113	4	and	and	CC
cord-016293-pyb00pt5	113	5	very	very	RB
cord-016293-pyb00pt5	113	6	public	public	JJ
cord-016293-pyb00pt5	113	7	ascent	ascent	NN
cord-016293-pyb00pt5	113	8	of	of	IN
cord-016293-pyb00pt5	113	9	recombinant	recombinant	JJ
cord-016293-pyb00pt5	113	10	DNA	dna	NN
cord-016293-pyb00pt5	113	11	technology	technology	NN
cord-016293-pyb00pt5	113	12	during	during	IN
cord-016293-pyb00pt5	113	13	the	the	DT
cord-016293-pyb00pt5	113	14	previous	previous	JJ
cord-016293-pyb00pt5	113	15	two	two	CD
cord-016293-pyb00pt5	113	16	decades	decade	NNS
cord-016293-pyb00pt5	113	17	,	,	,
cord-016293-pyb00pt5	113	18	the	the	DT
cord-016293-pyb00pt5	113	19	analytic	analytic	JJ
cord-016293-pyb00pt5	113	20	and	and	CC
cord-016293-pyb00pt5	113	21	management	management	NN
cord-016293-pyb00pt5	113	22	tools	tool	NNS
cord-016293-pyb00pt5	113	23	of	of	IN
cord-016293-pyb00pt5	113	24	the	the	DT
cord-016293-pyb00pt5	113	25	discipline	discipline	NN
cord-016293-pyb00pt5	113	26	that	that	WDT
cord-016293-pyb00pt5	113	27	was	be	VBD
cord-016293-pyb00pt5	113	28	to	to	TO
cord-016293-pyb00pt5	113	29	become	become	VB
cord-016293-pyb00pt5	113	30	bioinformatics	bioinformatic	NNS
cord-016293-pyb00pt5	113	31	evolved	evolve	VBN
cord-016293-pyb00pt5	113	32	at	at	IN
cord-016293-pyb00pt5	113	33	a	a	DT
cord-016293-pyb00pt5	113	34	more	more	RBR
cord-016293-pyb00pt5	113	35	subdued	subdued	JJ
cord-016293-pyb00pt5	113	36	but	but	CC
cord-016293-pyb00pt5	113	37	equally	equally	RB
cord-016293-pyb00pt5	113	38	impressive	impressive	JJ
cord-016293-pyb00pt5	113	39	pace	pace	NN
cord-016293-pyb00pt5	113	40	.	.	.
cord-016293-pyb00pt5	114	1	Some	some	DT
cord-016293-pyb00pt5	114	2	of	of	IN
cord-016293-pyb00pt5	114	3	the	the	DT
cord-016293-pyb00pt5	114	4	key	key	JJ
cord-016293-pyb00pt5	114	5	developments	development	NNS
cord-016293-pyb00pt5	114	6	included	include	VBD
cord-016293-pyb00pt5	114	7	tools	tool	NNS
cord-016293-pyb00pt5	114	8	such	such	JJ
cord-016293-pyb00pt5	114	9	as	as	IN
cord-016293-pyb00pt5	114	10	the	the	DT
cord-016293-pyb00pt5	114	11	Needleman	Needleman	NNP
cord-016293-pyb00pt5	114	12	-	-	HYPH
cord-016293-pyb00pt5	114	13	Wunsch	Wunsch	NNP
cord-016293-pyb00pt5	114	14	algorithm	algorithm	NN
cord-016293-pyb00pt5	114	15	for	for	IN
cord-016293-pyb00pt5	114	16	sequence	sequence	NN
cord-016293-pyb00pt5	114	17	comparison	comparison	NN
cord-016293-pyb00pt5	114	18	which	which	WDT
cord-016293-pyb00pt5	114	19	appeared	appear	VBD
cord-016293-pyb00pt5	114	20	even	even	RB
cord-016293-pyb00pt5	114	21	before	before	IN
cord-016293-pyb00pt5	114	22	recombinant	recombinant	JJ
cord-016293-pyb00pt5	114	23	DNA	dna	NN
cord-016293-pyb00pt5	114	24	technology	technology	NN
cord-016293-pyb00pt5	114	25	had	have	VBD
cord-016293-pyb00pt5	114	26	been	be	VBN
cord-016293-pyb00pt5	114	27	demonstrated	demonstrate	VBN
cord-016293-pyb00pt5	114	28	as	as	RB
cord-016293-pyb00pt5	114	29	early	early	RB
cord-016293-pyb00pt5	114	30	as	as	IN
cord-016293-pyb00pt5	114	31	1970	1970	CD
cord-016293-pyb00pt5	114	32	;	;	:
cord-016293-pyb00pt5	114	33	the	the	DT
cord-016293-pyb00pt5	114	34	Smith	Smith	NNP
cord-016293-pyb00pt5	114	35	-	-	HYPH
cord-016293-pyb00pt5	114	36	Waterman	Waterman	NNP
cord-016293-pyb00pt5	114	37	algorithm	algorithm	NN
cord-016293-pyb00pt5	114	38	for	for	IN
cord-016293-pyb00pt5	114	39	sequence	sequence	NN
cord-016293-pyb00pt5	114	40	alignment	alignment	NN
cord-016293-pyb00pt5	114	41	(	(	-LRB-
cord-016293-pyb00pt5	114	42	1974	1974	CD
cord-016293-pyb00pt5	114	43	)	)	-RRB-
cord-016293-pyb00pt5	114	44	;	;	:
cord-016293-pyb00pt5	114	45	the	the	DT
cord-016293-pyb00pt5	114	46	FASTP	FASTP	NNP
cord-016293-pyb00pt5	114	47	algorithm	algorithm	NN
cord-016293-pyb00pt5	114	48	(	(	-LRB-
cord-016293-pyb00pt5	114	49	1985	1985	CD
cord-016293-pyb00pt5	114	50	)	)	-RRB-
cord-016293-pyb00pt5	114	51	and	and	CC
cord-016293-pyb00pt5	114	52	the	the	DT
cord-016293-pyb00pt5	114	53	FASTA	FASTA	NNP
cord-016293-pyb00pt5	114	54	algorithm	algorithm	NN
cord-016293-pyb00pt5	114	55	for	for	IN
cord-016293-pyb00pt5	114	56	sequence	sequence	NN
cord-016293-pyb00pt5	114	57	comparison	comparison	NN
cord-016293-pyb00pt5	114	58	by	by	IN
cord-016293-pyb00pt5	114	59	Pearson	Pearson	NNP
cord-016293-pyb00pt5	114	60	and	and	CC
cord-016293-pyb00pt5	114	61	Lupman	Lupman	NNP
cord-016293-pyb00pt5	114	62	in	in	IN
cord-016293-pyb00pt5	114	63	1988	1988	CD
cord-016293-pyb00pt5	114	64	and	and	CC
cord-016293-pyb00pt5	114	65	Perl	Perl	NNP
cord-016293-pyb00pt5	114	66	(	(	-LRB-
cord-016293-pyb00pt5	114	67	Practical	Practical	NNP
cord-016293-pyb00pt5	114	68	Extraction	Extraction	NNP
cord-016293-pyb00pt5	114	69	Report	Report	NNP
cord-016293-pyb00pt5	114	70	Language	Language	NNP
cord-016293-pyb00pt5	114	71	)	)	-RRB-
cord-016293-pyb00pt5	114	72	released	release	VBN
cord-016293-pyb00pt5	114	73	by	by	IN
cord-016293-pyb00pt5	114	74	Larry	Larry	NNP
cord-016293-pyb00pt5	114	75	Wall	Wall	NNP
cord-016293-pyb00pt5	114	76	in	in	IN
cord-016293-pyb00pt5	114	77	1987	1987	CD
cord-016293-pyb00pt5	114	78	.	.	.
cord-016293-pyb00pt5	115	1	On	on	IN
cord-016293-pyb00pt5	115	2	the	the	DT
cord-016293-pyb00pt5	115	3	data	data	NN
cord-016293-pyb00pt5	115	4	management	management	NN
cord-016293-pyb00pt5	115	5	side	side	NN
cord-016293-pyb00pt5	115	6	several	several	JJ
cord-016293-pyb00pt5	115	7	databases	database	NNS
cord-016293-pyb00pt5	115	8	with	with	IN
cord-016293-pyb00pt5	115	9	ever	ever	RB
cord-016293-pyb00pt5	115	10	more	more	RBR
cord-016293-pyb00pt5	115	11	effective	effective	JJ
cord-016293-pyb00pt5	115	12	storage	storage	NN
cord-016293-pyb00pt5	115	13	and	and	CC
cord-016293-pyb00pt5	115	14	mining	mining	NN
cord-016293-pyb00pt5	115	15	capabilities	capability	NNS
cord-016293-pyb00pt5	115	16	were	be	VBD
cord-016293-pyb00pt5	115	17	developed	develop	VBN
cord-016293-pyb00pt5	115	18	over	over	IN
cord-016293-pyb00pt5	115	19	the	the	DT
cord-016293-pyb00pt5	115	20	same	same	JJ
cord-016293-pyb00pt5	115	21	period	period	NN
cord-016293-pyb00pt5	115	22	.	.	.
cord-016293-pyb00pt5	116	1	The	the	DT
cord-016293-pyb00pt5	116	2	first	first	JJ
cord-016293-pyb00pt5	116	3	bioinformatic	bioinformatic	JJ
cord-016293-pyb00pt5	116	4	/	/	SYM
cord-016293-pyb00pt5	116	5	biological	biological	JJ
cord-016293-pyb00pt5	116	6	databases	database	NNS
cord-016293-pyb00pt5	116	7	were	be	VBD
cord-016293-pyb00pt5	116	8	constructed	construct	VBN
cord-016293-pyb00pt5	116	9	a	a	DT
cord-016293-pyb00pt5	116	10	few	few	JJ
cord-016293-pyb00pt5	116	11	years	year	NNS
cord-016293-pyb00pt5	116	12	after	after	IN
cord-016293-pyb00pt5	116	13	the	the	DT
cord-016293-pyb00pt5	116	14	first	first	JJ
cord-016293-pyb00pt5	116	15	protein	protein	NN
cord-016293-pyb00pt5	116	16	sequences	sequence	NNS
cord-016293-pyb00pt5	116	17	began	begin	VBD
cord-016293-pyb00pt5	116	18	to	to	TO
cord-016293-pyb00pt5	116	19	become	become	VB
cord-016293-pyb00pt5	116	20	available	available	JJ
cord-016293-pyb00pt5	116	21	.	.	.
cord-016293-pyb00pt5	117	1	The	the	DT
cord-016293-pyb00pt5	117	2	first	first	JJ
cord-016293-pyb00pt5	117	3	protein	protein	NN
cord-016293-pyb00pt5	117	4	sequence	sequence	NN
cord-016293-pyb00pt5	117	5	reported	report	VBD
cord-016293-pyb00pt5	117	6	was	be	VBD
cord-016293-pyb00pt5	117	7	that	that	DT
cord-016293-pyb00pt5	117	8	of	of	IN
cord-016293-pyb00pt5	117	9	bovine	bovine	JJ
cord-016293-pyb00pt5	117	10	insulin	insulin	NN
cord-016293-pyb00pt5	117	11	in	in	IN
cord-016293-pyb00pt5	117	12	1956	1956	CD
cord-016293-pyb00pt5	117	13	,	,	,
cord-016293-pyb00pt5	117	14	consisting	consist	VBG
cord-016293-pyb00pt5	117	15	of	of	IN
cord-016293-pyb00pt5	117	16	51	51	CD
cord-016293-pyb00pt5	117	17	residues	residue	NNS
cord-016293-pyb00pt5	117	18	.	.	.
cord-016293-pyb00pt5	118	1	Nearly	nearly	RB
cord-016293-pyb00pt5	118	2	a	a	DT
cord-016293-pyb00pt5	118	3	decade	decade	NN
cord-016293-pyb00pt5	118	4	later	later	RB
cord-016293-pyb00pt5	118	5	,	,	,
cord-016293-pyb00pt5	118	6	the	the	DT
cord-016293-pyb00pt5	118	7	first	first	JJ
cord-016293-pyb00pt5	118	8	nucleic	nucleic	JJ
cord-016293-pyb00pt5	118	9	acid	acid	NN
cord-016293-pyb00pt5	118	10	sequence	sequence	NN
cord-016293-pyb00pt5	118	11	was	be	VBD
cord-016293-pyb00pt5	118	12	reported	report	VBN
cord-016293-pyb00pt5	118	13	,	,	,
cord-016293-pyb00pt5	118	14	that	that	DT
cord-016293-pyb00pt5	118	15	of	of	IN
cord-016293-pyb00pt5	118	16	yeast	yeast	NNP
cord-016293-pyb00pt5	118	17	alanine	alanine	NNP
cord-016293-pyb00pt5	118	18	tRNA	tRNA	NNP
cord-016293-pyb00pt5	118	19	with	with	IN
cord-016293-pyb00pt5	118	20	77	77	CD
cord-016293-pyb00pt5	118	21	bases	basis	NNS
cord-016293-pyb00pt5	118	22	.	.	.
cord-016293-pyb00pt5	119	1	Just	just	RB
cord-016293-pyb00pt5	119	2	one	one	CD
cord-016293-pyb00pt5	119	3	year	year	NN
cord-016293-pyb00pt5	119	4	later	later	RB
cord-016293-pyb00pt5	119	5	,	,	,
cord-016293-pyb00pt5	119	6	Dayhoff	Dayhoff	NNP
cord-016293-pyb00pt5	119	7	gathered	gather	VBD
cord-016293-pyb00pt5	119	8	all	all	PDT
cord-016293-pyb00pt5	119	9	the	the	DT
cord-016293-pyb00pt5	119	10	available	available	JJ
cord-016293-pyb00pt5	119	11	sequence	sequence	NN
cord-016293-pyb00pt5	119	12	data	datum	NNS
cord-016293-pyb00pt5	119	13	to	to	TO
cord-016293-pyb00pt5	119	14	create	create	VB
cord-016293-pyb00pt5	119	15	the	the	DT
cord-016293-pyb00pt5	119	16	first	first	JJ
cord-016293-pyb00pt5	119	17	bioinformatic	bioinformatic	JJ
cord-016293-pyb00pt5	119	18	database	database	NN
cord-016293-pyb00pt5	119	19	.	.	.
cord-016293-pyb00pt5	120	1	One	one	CD
cord-016293-pyb00pt5	120	2	of	of	IN
cord-016293-pyb00pt5	120	3	the	the	DT
cord-016293-pyb00pt5	120	4	first	first	JJ
cord-016293-pyb00pt5	120	5	dedicated	dedicated	JJ
cord-016293-pyb00pt5	120	6	databases	database	NNS
cord-016293-pyb00pt5	120	7	was	be	VBD
cord-016293-pyb00pt5	120	8	the	the	DT
cord-016293-pyb00pt5	120	9	Brookhaven	Brookhaven	NNP
cord-016293-pyb00pt5	120	10	Protein	Protein	NNP
cord-016293-pyb00pt5	120	11	DataBank	DataBank	NNP
cord-016293-pyb00pt5	120	12	whose	whose	WP$
cord-016293-pyb00pt5	120	13	collection	collection	NN
cord-016293-pyb00pt5	120	14	consisted	consist	VBD
cord-016293-pyb00pt5	120	15	of	of	IN
cord-016293-pyb00pt5	120	16	ten	ten	CD
cord-016293-pyb00pt5	120	17	X	x	NN
cord-016293-pyb00pt5	120	18	-	-	NN
cord-016293-pyb00pt5	120	19	ray	ray	JJ
cord-016293-pyb00pt5	120	20	crystallographic	crystallographic	JJ
cord-016293-pyb00pt5	120	21	protein	protein	NN
cord-016293-pyb00pt5	120	22	structures	structure	NNS
cord-016293-pyb00pt5	120	23	(	(	-LRB-
cord-016293-pyb00pt5	120	24	Acta	Acta	NNP
cord-016293-pyb00pt5	120	25	.	.	.
cord-016293-pyb00pt5	121	1	Cryst	Cryst	NNP
cord-016293-pyb00pt5	121	2	.	.	.
cord-016293-pyb00pt5	122	1	B	b	NN
cord-016293-pyb00pt5	122	2	,	,	,
cord-016293-pyb00pt5	122	3	1973	1973	CD
cord-016293-pyb00pt5	122	4	)	)	-RRB-
cord-016293-pyb00pt5	122	5	.	.	.
cord-016293-pyb00pt5	123	1	The	the	DT
cord-016293-pyb00pt5	123	2	year	year	NN
cord-016293-pyb00pt5	123	3	1982	1982	CD
cord-016293-pyb00pt5	123	4	saw	see	VBD
cord-016293-pyb00pt5	123	5	the	the	DT
cord-016293-pyb00pt5	123	6	creation	creation	NN
cord-016293-pyb00pt5	123	7	of	of	IN
cord-016293-pyb00pt5	123	8	the	the	DT
cord-016293-pyb00pt5	123	9	Genetics	Genetics	NNP
cord-016293-pyb00pt5	123	10	Computer	Computer	NNP
cord-016293-pyb00pt5	123	11	Group	Group	NNP
cord-016293-pyb00pt5	123	12	(	(	-LRB-
cord-016293-pyb00pt5	123	13	GCG	GCG	NNP
cord-016293-pyb00pt5	123	14	)	)	-RRB-
cord-016293-pyb00pt5	123	15	as	as	IN
cord-016293-pyb00pt5	123	16	a	a	DT
cord-016293-pyb00pt5	123	17	part	part	NN
cord-016293-pyb00pt5	123	18	of	of	IN
cord-016293-pyb00pt5	123	19	the	the	DT
cord-016293-pyb00pt5	123	20	University	University	NNP
cord-016293-pyb00pt5	123	21	of	of	IN
cord-016293-pyb00pt5	123	22	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	123	23	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	123	24	Center	Center	NNP
cord-016293-pyb00pt5	123	25	.	.	.
cord-016293-pyb00pt5	124	1	The	the	DT
cord-016293-pyb00pt5	124	2	group	group	NN
cord-016293-pyb00pt5	124	3	's	's	POS
cord-016293-pyb00pt5	124	4	primary	primary	JJ
cord-016293-pyb00pt5	124	5	and	and	CC
cord-016293-pyb00pt5	124	6	much	much	JJ
cord-016293-pyb00pt5	124	7	used	use	VBN
cord-016293-pyb00pt5	124	8	product	product	NN
cord-016293-pyb00pt5	124	9	was	be	VBD
cord-016293-pyb00pt5	124	10	the	the	DT
cord-016293-pyb00pt5	124	11	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	124	12	Suite	Suite	NNP
cord-016293-pyb00pt5	124	13	of	of	IN
cord-016293-pyb00pt5	124	14	molecular	molecular	JJ
cord-016293-pyb00pt5	124	15	biology	biology	NN
cord-016293-pyb00pt5	124	16	tools	tool	NNS
cord-016293-pyb00pt5	124	17	.	.	.
cord-016293-pyb00pt5	125	1	It	-PRON-	PRP
cord-016293-pyb00pt5	125	2	was	be	VBD
cord-016293-pyb00pt5	125	3	spun	spin	VBN
cord-016293-pyb00pt5	125	4	off	off	RP
cord-016293-pyb00pt5	125	5	as	as	IN
cord-016293-pyb00pt5	125	6	a	a	DT
cord-016293-pyb00pt5	125	7	private	private	JJ
cord-016293-pyb00pt5	125	8	company	company	NN
cord-016293-pyb00pt5	125	9	in	in	IN
cord-016293-pyb00pt5	125	10	1989	1989	CD
cord-016293-pyb00pt5	125	11	.	.	.
cord-016293-pyb00pt5	126	1	The	the	DT
cord-016293-pyb00pt5	126	2	SWISS	swiss	JJ
cord-016293-pyb00pt5	126	3	-	-	HYPH
cord-016293-pyb00pt5	126	4	PROT	prot	NN
cord-016293-pyb00pt5	126	5	database	database	NN
cord-016293-pyb00pt5	126	6	made	make	VBD
cord-016293-pyb00pt5	126	7	its	-PRON-	PRP$
cord-016293-pyb00pt5	126	8	debut	debut	NN
cord-016293-pyb00pt5	126	9	in	in	IN
cord-016293-pyb00pt5	126	10	1986	1986	CD
cord-016293-pyb00pt5	126	11	in	in	IN
cord-016293-pyb00pt5	126	12	Europe	Europe	NNP
cord-016293-pyb00pt5	126	13	at	at	IN
cord-016293-pyb00pt5	126	14	the	the	DT
cord-016293-pyb00pt5	126	15	Department	Department	NNP
cord-016293-pyb00pt5	126	16	of	of	IN
cord-016293-pyb00pt5	126	17	Medical	Medical	NNP
cord-016293-pyb00pt5	126	18	Biochemistry	Biochemistry	NNP
cord-016293-pyb00pt5	126	19	of	of	IN
cord-016293-pyb00pt5	126	20	the	the	DT
cord-016293-pyb00pt5	126	21	University	University	NNP
cord-016293-pyb00pt5	126	22	of	of	IN
cord-016293-pyb00pt5	126	23	Geneva	Geneva	NNP
cord-016293-pyb00pt5	126	24	and	and	CC
cord-016293-pyb00pt5	126	25	the	the	DT
cord-016293-pyb00pt5	126	26	European	European	NNP
cord-016293-pyb00pt5	126	27	Molecular	Molecular	NNP
cord-016293-pyb00pt5	126	28	Biology	Biology	NNP
cord-016293-pyb00pt5	126	29	Laboratory	Laboratory	NNP
cord-016293-pyb00pt5	126	30	(	(	-LRB-
cord-016293-pyb00pt5	126	31	EMBL	EMBL	NNP
cord-016293-pyb00pt5	126	32	)	)	-RRB-
cord-016293-pyb00pt5	126	33	.	.	.
cord-016293-pyb00pt5	127	1	The	the	DT
cord-016293-pyb00pt5	127	2	first	first	JJ
cord-016293-pyb00pt5	127	3	dedicated	dedicated	JJ
cord-016293-pyb00pt5	127	4	"	"	``
cord-016293-pyb00pt5	127	5	bioinformatics	bioinformatic	NNS
cord-016293-pyb00pt5	127	6	"	"	''
cord-016293-pyb00pt5	127	7	company	company	NN
cord-016293-pyb00pt5	127	8	IntelliGenetics	IntelliGenetics	NNP
cord-016293-pyb00pt5	127	9	,	,	,
cord-016293-pyb00pt5	127	10	Inc.	Inc.	NNP
cord-016293-pyb00pt5	127	11	was	be	VBD
cord-016293-pyb00pt5	127	12	founded	found	VBN
cord-016293-pyb00pt5	127	13	in	in	IN
cord-016293-pyb00pt5	127	14	California	California	NNP
cord-016293-pyb00pt5	127	15	in	in	IN
cord-016293-pyb00pt5	127	16	1980	1980	CD
cord-016293-pyb00pt5	127	17	.	.	.
cord-016293-pyb00pt5	128	1	Their	-PRON-	PRP$
cord-016293-pyb00pt5	128	2	primary	primary	JJ
cord-016293-pyb00pt5	128	3	product	product	NN
cord-016293-pyb00pt5	128	4	was	be	VBD
cord-016293-pyb00pt5	128	5	the	the	DT
cord-016293-pyb00pt5	128	6	IntelliGenetics	IntelliGenetics	NNP
cord-016293-pyb00pt5	128	7	Suite	Suite	NNP
cord-016293-pyb00pt5	128	8	of	of	IN
cord-016293-pyb00pt5	128	9	programs	program	NNS
cord-016293-pyb00pt5	128	10	for	for	IN
cord-016293-pyb00pt5	128	11	DNA	dna	NN
cord-016293-pyb00pt5	128	12	and	and	CC
cord-016293-pyb00pt5	128	13	protein	protein	NN
cord-016293-pyb00pt5	128	14	sequence	sequence	NN
cord-016293-pyb00pt5	128	15	analysis	analysis	NN
cord-016293-pyb00pt5	128	16	.	.	.
cord-016293-pyb00pt5	129	1	The	the	DT
cord-016293-pyb00pt5	129	2	first	first	JJ
cord-016293-pyb00pt5	129	3	unified	unified	JJ
cord-016293-pyb00pt5	129	4	federal	federal	JJ
cord-016293-pyb00pt5	129	5	effort	effort	NN
cord-016293-pyb00pt5	129	6	,	,	,
cord-016293-pyb00pt5	129	7	the	the	DT
cord-016293-pyb00pt5	129	8	National	National	NNP
cord-016293-pyb00pt5	129	9	Center	Center	NNP
cord-016293-pyb00pt5	129	10	for	for	IN
cord-016293-pyb00pt5	129	11	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	129	12	Information	Information	NNP
cord-016293-pyb00pt5	129	13	(	(	-LRB-
cord-016293-pyb00pt5	129	14	NCBI	NCBI	NNP
cord-016293-pyb00pt5	129	15	)	)	-RRB-
cord-016293-pyb00pt5	129	16	was	be	VBD
cord-016293-pyb00pt5	129	17	created	create	VBN
cord-016293-pyb00pt5	129	18	at	at	IN
cord-016293-pyb00pt5	129	19	NIH	NIH	NNP
cord-016293-pyb00pt5	129	20	/	/	SYM
cord-016293-pyb00pt5	129	21	NLM	NLM	NNP
cord-016293-pyb00pt5	129	22	in	in	IN
cord-016293-pyb00pt5	129	23	1988	1988	CD
cord-016293-pyb00pt5	129	24	and	and	CC
cord-016293-pyb00pt5	129	25	it	-PRON-	PRP
cord-016293-pyb00pt5	129	26	was	be	VBD
cord-016293-pyb00pt5	129	27	to	to	TO
cord-016293-pyb00pt5	129	28	play	play	VB
cord-016293-pyb00pt5	129	29	a	a	DT
cord-016293-pyb00pt5	129	30	crucial	crucial	JJ
cord-016293-pyb00pt5	129	31	part	part	NN
cord-016293-pyb00pt5	129	32	in	in	IN
cord-016293-pyb00pt5	129	33	coordinating	coordinate	VBG
cord-016293-pyb00pt5	129	34	public	public	JJ
cord-016293-pyb00pt5	129	35	databases	database	NNS
cord-016293-pyb00pt5	129	36	,	,	,
cord-016293-pyb00pt5	129	37	developing	develop	VBG
cord-016293-pyb00pt5	129	38	software	software	NN
cord-016293-pyb00pt5	129	39	tools	tool	NNS
cord-016293-pyb00pt5	129	40	for	for	IN
cord-016293-pyb00pt5	129	41	analyzing	analyze	VBG
cord-016293-pyb00pt5	129	42	genome	genome	NN
cord-016293-pyb00pt5	129	43	data	datum	NNS
cord-016293-pyb00pt5	129	44	,	,	,
cord-016293-pyb00pt5	129	45	and	and	CC
cord-016293-pyb00pt5	129	46	disseminating	disseminate	VBG
cord-016293-pyb00pt5	129	47	information	information	NN
cord-016293-pyb00pt5	129	48	.	.	.
cord-016293-pyb00pt5	130	1	And	and	CC
cord-016293-pyb00pt5	130	2	on	on	IN
cord-016293-pyb00pt5	130	3	the	the	DT
cord-016293-pyb00pt5	130	4	other	other	JJ
cord-016293-pyb00pt5	130	5	side	side	NN
cord-016293-pyb00pt5	130	6	of	of	IN
cord-016293-pyb00pt5	130	7	the	the	DT
cord-016293-pyb00pt5	130	8	Atlantic	Atlantic	NNP
cord-016293-pyb00pt5	130	9	,	,	,
cord-016293-pyb00pt5	130	10	Oxford	Oxford	NNP
cord-016293-pyb00pt5	130	11	Molecular	Molecular	NNP
cord-016293-pyb00pt5	130	12	Group	Group	NNP
cord-016293-pyb00pt5	130	13	,	,	,
cord-016293-pyb00pt5	130	14	Ltd.	Ltd.	NNP
cord-016293-pyb00pt5	130	15	(	(	-LRB-
cord-016293-pyb00pt5	130	16	OMG	omg	UH
cord-016293-pyb00pt5	130	17	)	)	-RRB-
cord-016293-pyb00pt5	130	18	was	be	VBD
cord-016293-pyb00pt5	130	19	founded	found	VBN
cord-016293-pyb00pt5	130	20	in	in	IN
cord-016293-pyb00pt5	130	21	Oxford	Oxford	NNP
cord-016293-pyb00pt5	130	22	,	,	,
cord-016293-pyb00pt5	130	23	UK	UK	NNP
cord-016293-pyb00pt5	130	24	by	by	IN
cord-016293-pyb00pt5	130	25	Anthony	Anthony	NNP
cord-016293-pyb00pt5	130	26	Marchington	Marchington	NNP
cord-016293-pyb00pt5	130	27	,	,	,
cord-016293-pyb00pt5	130	28	David	David	NNP
cord-016293-pyb00pt5	130	29	Ricketts	Ricketts	NNP
cord-016293-pyb00pt5	130	30	,	,	,
cord-016293-pyb00pt5	130	31	James	James	NNP
cord-016293-pyb00pt5	130	32	Hiddleston	Hiddleston	NNP
cord-016293-pyb00pt5	130	33	,	,	,
cord-016293-pyb00pt5	130	34	Anthony	Anthony	NNP
cord-016293-pyb00pt5	130	35	Rees	Rees	NNP
cord-016293-pyb00pt5	130	36	,	,	,
cord-016293-pyb00pt5	130	37	and	and	CC
cord-016293-pyb00pt5	130	38	W.	W.	NNP
cord-016293-pyb00pt5	130	39	Graham	Graham	NNP
cord-016293-pyb00pt5	130	40	Richards	Richards	NNP
cord-016293-pyb00pt5	130	41	.	.	.
cord-016293-pyb00pt5	131	1	Their	-PRON-	PRP$
cord-016293-pyb00pt5	131	2	primary	primary	JJ
cord-016293-pyb00pt5	131	3	focus	focus	NN
cord-016293-pyb00pt5	131	4	was	be	VBD
cord-016293-pyb00pt5	131	5	on	on	IN
cord-016293-pyb00pt5	131	6	rational	rational	JJ
cord-016293-pyb00pt5	131	7	drug	drug	NN
cord-016293-pyb00pt5	131	8	design	design	NN
cord-016293-pyb00pt5	131	9	and	and	CC
cord-016293-pyb00pt5	131	10	their	-PRON-	PRP$
cord-016293-pyb00pt5	131	11	products	product	NNS
cord-016293-pyb00pt5	131	12	such	such	JJ
cord-016293-pyb00pt5	131	13	as	as	IN
cord-016293-pyb00pt5	131	14	Anaconda	Anaconda	NNP
cord-016293-pyb00pt5	131	15	,	,	,
cord-016293-pyb00pt5	131	16	Asp	Asp	NNP
cord-016293-pyb00pt5	131	17	,	,	,
cord-016293-pyb00pt5	131	18	and	and	CC
cord-016293-pyb00pt5	131	19	Chameleon	Chameleon	NNP
cord-016293-pyb00pt5	131	20	obviously	obviously	RB
cord-016293-pyb00pt5	131	21	reflected	reflect	VBD
cord-016293-pyb00pt5	131	22	this	this	DT
cord-016293-pyb00pt5	131	23	as	as	IN
cord-016293-pyb00pt5	131	24	they	-PRON-	PRP
cord-016293-pyb00pt5	131	25	were	be	VBD
cord-016293-pyb00pt5	131	26	applied	apply	VBN
cord-016293-pyb00pt5	131	27	in	in	IN
cord-016293-pyb00pt5	131	28	molecular	molecular	JJ
cord-016293-pyb00pt5	131	29	modeling	modeling	NN
cord-016293-pyb00pt5	131	30	,	,	,
cord-016293-pyb00pt5	131	31	and	and	CC
cord-016293-pyb00pt5	131	32	protein	protein	NN
cord-016293-pyb00pt5	131	33	design	design	NN
cord-016293-pyb00pt5	131	34	engineering	engineering	NN
cord-016293-pyb00pt5	131	35	.	.	.
cord-016293-pyb00pt5	132	1	Within	within	IN
cord-016293-pyb00pt5	132	2	two	two	CD
cord-016293-pyb00pt5	132	3	years	year	NNS
cord-016293-pyb00pt5	132	4	NCBI	NCBI	NNP
cord-016293-pyb00pt5	132	5	were	be	VBD
cord-016293-pyb00pt5	132	6	making	make	VBG
cord-016293-pyb00pt5	132	7	their	-PRON-	PRP$
cord-016293-pyb00pt5	132	8	mark	mark	NN
cord-016293-pyb00pt5	132	9	when	when	WRB
cord-016293-pyb00pt5	132	10	David	David	NNP
cord-016293-pyb00pt5	132	11	Lipman	Lipman	NNP
cord-016293-pyb00pt5	132	12	,	,	,
cord-016293-pyb00pt5	132	13	Eugene	Eugene	NNP
cord-016293-pyb00pt5	132	14	Myers	Myers	NNP
cord-016293-pyb00pt5	132	15	,	,	,
cord-016293-pyb00pt5	132	16	and	and	CC
cord-016293-pyb00pt5	132	17	colleagues	colleague	NNS
cord-016293-pyb00pt5	132	18	at	at	IN
cord-016293-pyb00pt5	132	19	the	the	DT
cord-016293-pyb00pt5	132	20	NCBI	NCBI	NNP
cord-016293-pyb00pt5	132	21	published	publish	VBD
cord-016293-pyb00pt5	132	22	the	the	DT
cord-016293-pyb00pt5	132	23	Basic	Basic	NNP
cord-016293-pyb00pt5	132	24	Local	Local	NNP
cord-016293-pyb00pt5	132	25	Alignment	Alignment	NNP
cord-016293-pyb00pt5	132	26	Search	Search	NNP
cord-016293-pyb00pt5	132	27	Tool	Tool	NNP
cord-016293-pyb00pt5	132	28	BLAST	blast	NN
cord-016293-pyb00pt5	132	29	algorithm	algorithm	NN
cord-016293-pyb00pt5	132	30	for	for	IN
cord-016293-pyb00pt5	132	31	aligning	align	VBG
cord-016293-pyb00pt5	132	32	sequences	sequence	NNS
cord-016293-pyb00pt5	132	33	(	(	-LRB-
cord-016293-pyb00pt5	132	34	Altschul	Altschul	NNP
cord-016293-pyb00pt5	132	35	et	et	FW
cord-016293-pyb00pt5	132	36	al	al	NNP
cord-016293-pyb00pt5	132	37	.	.	NNP
cord-016293-pyb00pt5	132	38	,	,	,
cord-016293-pyb00pt5	132	39	1990	1990	CD
cord-016293-pyb00pt5	132	40	)	)	-RRB-
cord-016293-pyb00pt5	132	41	.	.	.
cord-016293-pyb00pt5	133	1	It	-PRON-	PRP
cord-016293-pyb00pt5	133	2	is	be	VBZ
cord-016293-pyb00pt5	133	3	used	use	VBN
cord-016293-pyb00pt5	133	4	to	to	TO
cord-016293-pyb00pt5	133	5	compare	compare	VB
cord-016293-pyb00pt5	133	6	a	a	DT
cord-016293-pyb00pt5	133	7	novel	novel	JJ
cord-016293-pyb00pt5	133	8	sequence	sequence	NN
cord-016293-pyb00pt5	133	9	with	with	IN
cord-016293-pyb00pt5	133	10	those	those	DT
cord-016293-pyb00pt5	133	11	contained	contain	VBN
cord-016293-pyb00pt5	133	12	in	in	IN
cord-016293-pyb00pt5	133	13	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	133	14	and	and	CC
cord-016293-pyb00pt5	133	15	protein	protein	NN
cord-016293-pyb00pt5	133	16	databases	database	NNS
cord-016293-pyb00pt5	133	17	by	by	IN
cord-016293-pyb00pt5	133	18	aligning	align	VBG
cord-016293-pyb00pt5	133	19	the	the	DT
cord-016293-pyb00pt5	133	20	novel	novel	JJ
cord-016293-pyb00pt5	133	21	sequence	sequence	NN
cord-016293-pyb00pt5	133	22	with	with	IN
cord-016293-pyb00pt5	133	23	previously	previously	RB
cord-016293-pyb00pt5	133	24	characterized	characterize	VBN
cord-016293-pyb00pt5	133	25	genes	gene	NNS
cord-016293-pyb00pt5	133	26	.	.	.
cord-016293-pyb00pt5	134	1	The	the	DT
cord-016293-pyb00pt5	134	2	emphasis	emphasis	NN
cord-016293-pyb00pt5	134	3	of	of	IN
cord-016293-pyb00pt5	134	4	this	this	DT
cord-016293-pyb00pt5	134	5	tool	tool	NN
cord-016293-pyb00pt5	134	6	is	be	VBZ
cord-016293-pyb00pt5	134	7	to	to	TO
cord-016293-pyb00pt5	134	8	find	find	VB
cord-016293-pyb00pt5	134	9	regions	region	NNS
cord-016293-pyb00pt5	134	10	of	of	IN
cord-016293-pyb00pt5	134	11	sequence	sequence	NN
cord-016293-pyb00pt5	134	12	similarity	similarity	NN
cord-016293-pyb00pt5	134	13	,	,	,
cord-016293-pyb00pt5	134	14	which	which	WDT
cord-016293-pyb00pt5	134	15	will	will	MD
cord-016293-pyb00pt5	134	16	yield	yield	VB
cord-016293-pyb00pt5	134	17	functional	functional	JJ
cord-016293-pyb00pt5	134	18	and	and	CC
cord-016293-pyb00pt5	134	19	evolutionary	evolutionary	JJ
cord-016293-pyb00pt5	134	20	clues	clue	NNS
cord-016293-pyb00pt5	134	21	about	about	IN
cord-016293-pyb00pt5	134	22	the	the	DT
cord-016293-pyb00pt5	134	23	structure	structure	NN
cord-016293-pyb00pt5	134	24	and	and	CC
cord-016293-pyb00pt5	134	25	function	function	NN
cord-016293-pyb00pt5	134	26	of	of	IN
cord-016293-pyb00pt5	134	27	this	this	DT
cord-016293-pyb00pt5	134	28	novel	novel	JJ
cord-016293-pyb00pt5	134	29	sequence	sequence	NN
cord-016293-pyb00pt5	134	30	.	.	.
cord-016293-pyb00pt5	135	1	Regions	region	NNS
cord-016293-pyb00pt5	135	2	of	of	IN
cord-016293-pyb00pt5	135	3	similarity	similarity	NN
cord-016293-pyb00pt5	135	4	detected	detect	VBN
cord-016293-pyb00pt5	135	5	via	via	IN
cord-016293-pyb00pt5	135	6	this	this	DT
cord-016293-pyb00pt5	135	7	type	type	NN
cord-016293-pyb00pt5	135	8	of	of	IN
cord-016293-pyb00pt5	135	9	alignment	alignment	NN
cord-016293-pyb00pt5	135	10	tool	tool	NN
cord-016293-pyb00pt5	135	11	can	can	MD
cord-016293-pyb00pt5	135	12	be	be	VB
cord-016293-pyb00pt5	135	13	either	either	CC
cord-016293-pyb00pt5	135	14	local	local	JJ
cord-016293-pyb00pt5	135	15	,	,	,
cord-016293-pyb00pt5	135	16	where	where	WRB
cord-016293-pyb00pt5	135	17	the	the	DT
cord-016293-pyb00pt5	135	18	region	region	NN
cord-016293-pyb00pt5	135	19	of	of	IN
cord-016293-pyb00pt5	135	20	similarity	similarity	NN
cord-016293-pyb00pt5	135	21	is	be	VBZ
cord-016293-pyb00pt5	135	22	based	base	VBN
cord-016293-pyb00pt5	135	23	in	in	IN
cord-016293-pyb00pt5	135	24	one	one	CD
cord-016293-pyb00pt5	135	25	location	location	NN
cord-016293-pyb00pt5	135	26	,	,	,
cord-016293-pyb00pt5	135	27	or	or	CC
cord-016293-pyb00pt5	135	28	global	global	JJ
cord-016293-pyb00pt5	135	29	,	,	,
cord-016293-pyb00pt5	135	30	where	where	WRB
cord-016293-pyb00pt5	135	31	regions	region	NNS
cord-016293-pyb00pt5	135	32	of	of	IN
cord-016293-pyb00pt5	135	33	similarity	similarity	NN
cord-016293-pyb00pt5	135	34	can	can	MD
cord-016293-pyb00pt5	135	35	be	be	VB
cord-016293-pyb00pt5	135	36	detected	detect	VBN
cord-016293-pyb00pt5	135	37	across	across	IN
cord-016293-pyb00pt5	135	38	otherwise	otherwise	RB
cord-016293-pyb00pt5	135	39	unrelated	unrelated	JJ
cord-016293-pyb00pt5	135	40	genetic	genetic	JJ
cord-016293-pyb00pt5	135	41	code	code	NN
cord-016293-pyb00pt5	135	42	.	.	.
cord-016293-pyb00pt5	136	1	The	the	DT
cord-016293-pyb00pt5	136	2	fundamental	fundamental	JJ
cord-016293-pyb00pt5	136	3	unit	unit	NN
cord-016293-pyb00pt5	136	4	of	of	IN
cord-016293-pyb00pt5	136	5	BLAST	blast	NN
cord-016293-pyb00pt5	136	6	algorithm	algorithm	NN
cord-016293-pyb00pt5	136	7	output	output	NN
cord-016293-pyb00pt5	136	8	is	be	VBZ
cord-016293-pyb00pt5	136	9	the	the	DT
cord-016293-pyb00pt5	136	10	High	High	NNP
cord-016293-pyb00pt5	136	11	-	-	HYPH
cord-016293-pyb00pt5	136	12	scoring	score	VBG
cord-016293-pyb00pt5	136	13	Segment	Segment	NNP
cord-016293-pyb00pt5	136	14	Pair	Pair	NNP
cord-016293-pyb00pt5	136	15	(	(	-LRB-
cord-016293-pyb00pt5	136	16	HSP	HSP	NNP
cord-016293-pyb00pt5	136	17	)	)	-RRB-
cord-016293-pyb00pt5	136	18	.	.	.
cord-016293-pyb00pt5	137	1	An	an	DT
cord-016293-pyb00pt5	137	2	HSP	HSP	NNP
cord-016293-pyb00pt5	137	3	consists	consist	VBZ
cord-016293-pyb00pt5	137	4	of	of	IN
cord-016293-pyb00pt5	137	5	two	two	CD
cord-016293-pyb00pt5	137	6	sequence	sequence	NN
cord-016293-pyb00pt5	137	7	fragments	fragment	NNS
cord-016293-pyb00pt5	137	8	of	of	IN
cord-016293-pyb00pt5	137	9	arbitrary	arbitrary	JJ
cord-016293-pyb00pt5	137	10	but	but	CC
cord-016293-pyb00pt5	137	11	equal	equal	JJ
cord-016293-pyb00pt5	137	12	length	length	NN
cord-016293-pyb00pt5	137	13	whose	whose	WP$
cord-016293-pyb00pt5	137	14	alignment	alignment	NN
cord-016293-pyb00pt5	137	15	is	be	VBZ
cord-016293-pyb00pt5	137	16	locally	locally	RB
cord-016293-pyb00pt5	137	17	maximal	maximal	JJ
cord-016293-pyb00pt5	137	18	and	and	CC
cord-016293-pyb00pt5	137	19	for	for	IN
cord-016293-pyb00pt5	137	20	which	which	WDT
cord-016293-pyb00pt5	137	21	the	the	DT
cord-016293-pyb00pt5	137	22	alignment	alignment	NN
cord-016293-pyb00pt5	137	23	score	score	NN
cord-016293-pyb00pt5	137	24	meets	meet	VBZ
cord-016293-pyb00pt5	137	25	or	or	CC
cord-016293-pyb00pt5	137	26	exceeds	exceed	VBZ
cord-016293-pyb00pt5	137	27	a	a	DT
cord-016293-pyb00pt5	137	28	threshold	threshold	NN
cord-016293-pyb00pt5	137	29	or	or	CC
cord-016293-pyb00pt5	137	30	cutoff	cutoff	NN
cord-016293-pyb00pt5	137	31	score	score	NN
cord-016293-pyb00pt5	137	32	.	.	.
cord-016293-pyb00pt5	138	1	This	this	DT
cord-016293-pyb00pt5	138	2	system	system	NN
cord-016293-pyb00pt5	138	3	has	have	VBZ
cord-016293-pyb00pt5	138	4	been	be	VBN
cord-016293-pyb00pt5	138	5	refined	refine	VBN
cord-016293-pyb00pt5	138	6	and	and	CC
cord-016293-pyb00pt5	138	7	modified	modify	VBN
cord-016293-pyb00pt5	138	8	over	over	IN
cord-016293-pyb00pt5	138	9	the	the	DT
cord-016293-pyb00pt5	138	10	years	year	NNS
cord-016293-pyb00pt5	138	11	the	the	DT
cord-016293-pyb00pt5	138	12	two	two	CD
cord-016293-pyb00pt5	138	13	principal	principal	JJ
cord-016293-pyb00pt5	138	14	variants	variant	NNS
cord-016293-pyb00pt5	138	15	presently	presently	RB
cord-016293-pyb00pt5	138	16	in	in	IN
cord-016293-pyb00pt5	138	17	use	use	NN
cord-016293-pyb00pt5	138	18	being	be	VBG
cord-016293-pyb00pt5	138	19	the	the	DT
cord-016293-pyb00pt5	138	20	NCBI	NCBI	NNP
cord-016293-pyb00pt5	138	21	BLAST	blast	NN
cord-016293-pyb00pt5	138	22	and	and	CC
cord-016293-pyb00pt5	138	23	WU	WU	NNP
cord-016293-pyb00pt5	138	24	-	-	HYPH
cord-016293-pyb00pt5	138	25	BLAST	BLAST	NNP
cord-016293-pyb00pt5	138	26	(	(	-LRB-
cord-016293-pyb00pt5	138	27	WU	WU	NNP
cord-016293-pyb00pt5	138	28	signifying	signify	VBG
cord-016293-pyb00pt5	138	29	Washington	Washington	NNP
cord-016293-pyb00pt5	138	30	University	University	NNP
cord-016293-pyb00pt5	138	31	)	)	-RRB-
cord-016293-pyb00pt5	138	32	.	.	.
cord-016293-pyb00pt5	139	1	The	the	DT
cord-016293-pyb00pt5	139	2	same	same	JJ
cord-016293-pyb00pt5	139	3	year	year	NN
cord-016293-pyb00pt5	139	4	that	that	WDT
cord-016293-pyb00pt5	139	5	BLAST	blast	NN
cord-016293-pyb00pt5	139	6	was	be	VBD
cord-016293-pyb00pt5	139	7	launched	launch	VBN
cord-016293-pyb00pt5	139	8	two	two	CD
cord-016293-pyb00pt5	139	9	other	other	JJ
cord-016293-pyb00pt5	139	10	bioinformatics	bioinformatics	NN
cord-016293-pyb00pt5	139	11	companies	company	NNS
cord-016293-pyb00pt5	139	12	were	be	VBD
cord-016293-pyb00pt5	139	13	launched	launch	VBN
cord-016293-pyb00pt5	139	14	.	.	.
cord-016293-pyb00pt5	140	1	One	one	CD
cord-016293-pyb00pt5	140	2	was	be	VBD
cord-016293-pyb00pt5	140	3	InforMax	InforMax	NNP
cord-016293-pyb00pt5	140	4	in	in	IN
cord-016293-pyb00pt5	140	5	Bethesda	Bethesda	NNP
cord-016293-pyb00pt5	140	6	,	,	,
cord-016293-pyb00pt5	140	7	MD	MD	NNP
cord-016293-pyb00pt5	140	8	whose	whose	WP$
cord-016293-pyb00pt5	140	9	products	product	NNS
cord-016293-pyb00pt5	140	10	addressed	address	VBD
cord-016293-pyb00pt5	140	11	sequence	sequence	NN
cord-016293-pyb00pt5	140	12	analysis	analysis	NN
cord-016293-pyb00pt5	140	13	,	,	,
cord-016293-pyb00pt5	140	14	database	database	NN
cord-016293-pyb00pt5	140	15	and	and	CC
cord-016293-pyb00pt5	140	16	data	datum	NNS
cord-016293-pyb00pt5	140	17	management	management	NN
cord-016293-pyb00pt5	140	18	,	,	,
cord-016293-pyb00pt5	140	19	searching	searching	NN
cord-016293-pyb00pt5	140	20	,	,	,
cord-016293-pyb00pt5	140	21	publication	publication	NN
cord-016293-pyb00pt5	140	22	graphics	graphic	NNS
cord-016293-pyb00pt5	140	23	,	,	,
cord-016293-pyb00pt5	140	24	clone	clone	NN
cord-016293-pyb00pt5	140	25	construction	construction	NN
cord-016293-pyb00pt5	140	26	,	,	,
cord-016293-pyb00pt5	140	27	mapping	mapping	NN
cord-016293-pyb00pt5	140	28	and	and	CC
cord-016293-pyb00pt5	140	29	primer	primer	NN
cord-016293-pyb00pt5	140	30	design	design	NN
cord-016293-pyb00pt5	140	31	.	.	.
cord-016293-pyb00pt5	141	1	The	the	DT
cord-016293-pyb00pt5	141	2	second	second	JJ
cord-016293-pyb00pt5	141	3	,	,	,
cord-016293-pyb00pt5	141	4	Molecular	Molecular	NNP
cord-016293-pyb00pt5	141	5	Applications	Applications	NNPS
cord-016293-pyb00pt5	141	6	Group	Group	NNP
cord-016293-pyb00pt5	141	7	in	in	IN
cord-016293-pyb00pt5	141	8	California	California	NNP
cord-016293-pyb00pt5	141	9	,	,	,
cord-016293-pyb00pt5	141	10	was	be	VBD
cord-016293-pyb00pt5	141	11	to	to	TO
cord-016293-pyb00pt5	141	12	play	play	VB
cord-016293-pyb00pt5	141	13	a	a	DT
cord-016293-pyb00pt5	141	14	bigger	big	JJR
cord-016293-pyb00pt5	141	15	part	part	NN
cord-016293-pyb00pt5	141	16	on	on	IN
cord-016293-pyb00pt5	141	17	the	the	DT
cord-016293-pyb00pt5	141	18	proteomics	proteomic	NNS
cord-016293-pyb00pt5	141	19	end	end	NN
cord-016293-pyb00pt5	142	1	(	(	-LRB-
cord-016293-pyb00pt5	142	2	Michael	Michael	NNP
cord-016293-pyb00pt5	142	3	Levitt	Levitt	NNP
cord-016293-pyb00pt5	142	4	and	and	CC
cord-016293-pyb00pt5	142	5	Chris	Chris	NNP
cord-016293-pyb00pt5	142	6	Lee	Lee	NNP
cord-016293-pyb00pt5	142	7	)	)	-RRB-
cord-016293-pyb00pt5	142	8	.	.	.
cord-016293-pyb00pt5	143	1	Their	-PRON-	PRP$
cord-016293-pyb00pt5	143	2	primary	primary	JJ
cord-016293-pyb00pt5	143	3	products	product	NNS
cord-016293-pyb00pt5	143	4	were	be	VBD
cord-016293-pyb00pt5	143	5	Look	look	VB
cord-016293-pyb00pt5	143	6	and	and	CC
cord-016293-pyb00pt5	143	7	SegMod	SegMod	NNP
cord-016293-pyb00pt5	143	8	which	which	WDT
cord-016293-pyb00pt5	143	9	are	be	VBP
cord-016293-pyb00pt5	143	10	used	use	VBN
cord-016293-pyb00pt5	143	11	for	for	IN
cord-016293-pyb00pt5	143	12	molecular	molecular	JJ
cord-016293-pyb00pt5	143	13	modeling	modeling	NN
cord-016293-pyb00pt5	143	14	and	and	CC
cord-016293-pyb00pt5	143	15	protein	protein	NN
cord-016293-pyb00pt5	143	16	design	design	NN
cord-016293-pyb00pt5	143	17	.	.	.
cord-016293-pyb00pt5	144	1	The	the	DT
cord-016293-pyb00pt5	144	2	following	following	JJ
cord-016293-pyb00pt5	144	3	year	year	NN
cord-016293-pyb00pt5	144	4	in	in	IN
cord-016293-pyb00pt5	144	5	1991	1991	CD
cord-016293-pyb00pt5	144	6	the	the	DT
cord-016293-pyb00pt5	144	7	Human	Human	NNP
cord-016293-pyb00pt5	144	8	chromosome	chromosome	NN
cord-016293-pyb00pt5	144	9	mapping	mapping	NN
cord-016293-pyb00pt5	144	10	data	datum	NNS
cord-016293-pyb00pt5	144	11	repository	repository	NN
cord-016293-pyb00pt5	144	12	,	,	,
cord-016293-pyb00pt5	144	13	Genome	Genome	NNP
cord-016293-pyb00pt5	144	14	Data	Data	NNP
cord-016293-pyb00pt5	144	15	Base	Base	NNP
cord-016293-pyb00pt5	144	16	(	(	-LRB-
cord-016293-pyb00pt5	144	17	GDB	GDB	NNP
cord-016293-pyb00pt5	144	18	)	)	-RRB-
cord-016293-pyb00pt5	144	19	was	be	VBD
cord-016293-pyb00pt5	144	20	established	establish	VBN
cord-016293-pyb00pt5	144	21	.	.	.
cord-016293-pyb00pt5	145	1	On	on	IN
cord-016293-pyb00pt5	145	2	a	a	DT
cord-016293-pyb00pt5	145	3	more	more	RBR
cord-016293-pyb00pt5	145	4	global	global	JJ
cord-016293-pyb00pt5	145	5	level	level	NN
cord-016293-pyb00pt5	145	6	,	,	,
cord-016293-pyb00pt5	145	7	the	the	DT
cord-016293-pyb00pt5	145	8	development	development	NN
cord-016293-pyb00pt5	145	9	of	of	IN
cord-016293-pyb00pt5	145	10	computational	computational	JJ
cord-016293-pyb00pt5	145	11	capabilities	capability	NNS
cord-016293-pyb00pt5	145	12	in	in	IN
cord-016293-pyb00pt5	145	13	general	general	JJ
cord-016293-pyb00pt5	145	14	and	and	CC
cord-016293-pyb00pt5	145	15	the	the	DT
cord-016293-pyb00pt5	145	16	Internet	internet	NN
cord-016293-pyb00pt5	145	17	in	in	IN
cord-016293-pyb00pt5	145	18	specific	specific	JJ
cord-016293-pyb00pt5	145	19	was	be	VBD
cord-016293-pyb00pt5	145	20	also	also	RB
cord-016293-pyb00pt5	145	21	to	to	TO
cord-016293-pyb00pt5	145	22	play	play	VB
cord-016293-pyb00pt5	145	23	a	a	DT
cord-016293-pyb00pt5	145	24	considerable	considerable	JJ
cord-016293-pyb00pt5	145	25	part	part	NN
cord-016293-pyb00pt5	145	26	in	in	IN
cord-016293-pyb00pt5	145	27	the	the	DT
cord-016293-pyb00pt5	145	28	sharing	sharing	NN
cord-016293-pyb00pt5	145	29	of	of	IN
cord-016293-pyb00pt5	145	30	data	datum	NNS
cord-016293-pyb00pt5	145	31	and	and	CC
cord-016293-pyb00pt5	145	32	access	access	NN
cord-016293-pyb00pt5	145	33	to	to	IN
cord-016293-pyb00pt5	145	34	databases	database	NNS
cord-016293-pyb00pt5	145	35	that	that	WDT
cord-016293-pyb00pt5	145	36	rendered	render	VBD
cord-016293-pyb00pt5	145	37	the	the	DT
cord-016293-pyb00pt5	145	38	rapidity	rapidity	NN
cord-016293-pyb00pt5	145	39	of	of	IN
cord-016293-pyb00pt5	145	40	the	the	DT
cord-016293-pyb00pt5	145	41	forward	forward	JJ
cord-016293-pyb00pt5	145	42	momentum	momentum	NN
cord-016293-pyb00pt5	145	43	of	of	IN
cord-016293-pyb00pt5	145	44	the	the	DT
cord-016293-pyb00pt5	145	45	HGP	HGP	NNP
cord-016293-pyb00pt5	145	46	possible	possible	JJ
cord-016293-pyb00pt5	145	47	.	.	.
cord-016293-pyb00pt5	146	1	Also	also	RB
cord-016293-pyb00pt5	146	2	in	in	IN
cord-016293-pyb00pt5	146	3	1991	1991	CD
cord-016293-pyb00pt5	146	4	Edward	Edward	NNP
cord-016293-pyb00pt5	146	5	Uberbacher	Uberbacher	NNP
cord-016293-pyb00pt5	146	6	of	of	IN
cord-016293-pyb00pt5	146	7	Oak	Oak	NNP
cord-016293-pyb00pt5	146	8	Ridge	Ridge	NNP
cord-016293-pyb00pt5	146	9	National	National	NNP
cord-016293-pyb00pt5	146	10	Laboratory	Laboratory	NNP
cord-016293-pyb00pt5	146	11	in	in	IN
cord-016293-pyb00pt5	146	12	Tennessee	Tennessee	NNP
cord-016293-pyb00pt5	146	13	developed	develop	VBD
cord-016293-pyb00pt5	146	14	GRAIL	GRAIL	NNP
cord-016293-pyb00pt5	146	15	,	,	,
cord-016293-pyb00pt5	146	16	the	the	DT
cord-016293-pyb00pt5	146	17	first	first	JJ
cord-016293-pyb00pt5	146	18	of	of	IN
cord-016293-pyb00pt5	146	19	many	many	JJ
cord-016293-pyb00pt5	146	20	gene	gene	NN
cord-016293-pyb00pt5	146	21	-	-	HYPH
cord-016293-pyb00pt5	146	22	finding	find	VBG
cord-016293-pyb00pt5	146	23	programs	program	NNS
cord-016293-pyb00pt5	146	24	.	.	.
cord-016293-pyb00pt5	147	1	In	in	IN
cord-016293-pyb00pt5	147	2	1992	1992	CD
cord-016293-pyb00pt5	147	3	the	the	DT
cord-016293-pyb00pt5	147	4	first	first	JJ
cord-016293-pyb00pt5	147	5	two	two	CD
cord-016293-pyb00pt5	147	6	"	"	``
cord-016293-pyb00pt5	147	7	genomics	genomic	NNS
cord-016293-pyb00pt5	147	8	"	"	''
cord-016293-pyb00pt5	147	9	companies	company	NNS
cord-016293-pyb00pt5	147	10	made	make	VBD
cord-016293-pyb00pt5	147	11	their	-PRON-	PRP$
cord-016293-pyb00pt5	147	12	appearance	appearance	NN
cord-016293-pyb00pt5	147	13	.	.	.
cord-016293-pyb00pt5	148	1	Incyte	Incyte	NNP
cord-016293-pyb00pt5	148	2	Pharmaceuticals	Pharmaceuticals	NNP
cord-016293-pyb00pt5	148	3	,	,	,
cord-016293-pyb00pt5	148	4	a	a	DT
cord-016293-pyb00pt5	148	5	genomics	genomic	NNS
cord-016293-pyb00pt5	148	6	company	company	NN
cord-016293-pyb00pt5	148	7	headquartered	headquarter	VBN
cord-016293-pyb00pt5	148	8	in	in	IN
cord-016293-pyb00pt5	148	9	Palo	Palo	NNP
cord-016293-pyb00pt5	148	10	Alto	Alto	NNP
cord-016293-pyb00pt5	148	11	,	,	,
cord-016293-pyb00pt5	148	12	California	California	NNP
cord-016293-pyb00pt5	148	13	,	,	,
cord-016293-pyb00pt5	148	14	was	be	VBD
cord-016293-pyb00pt5	148	15	formed	form	VBN
cord-016293-pyb00pt5	148	16	and	and	CC
cord-016293-pyb00pt5	148	17	Myriad	Myriad	NNP
cord-016293-pyb00pt5	148	18	Genetics	Genetics	NNP
cord-016293-pyb00pt5	148	19	,	,	,
cord-016293-pyb00pt5	148	20	Inc.	Inc.	NNP
cord-016293-pyb00pt5	148	21	was	be	VBD
cord-016293-pyb00pt5	148	22	founded	found	VBN
cord-016293-pyb00pt5	148	23	in	in	IN
cord-016293-pyb00pt5	148	24	Utah	Utah	NNP
cord-016293-pyb00pt5	148	25	.	.	.
cord-016293-pyb00pt5	149	1	Incyte	Incyte	NNP
cord-016293-pyb00pt5	149	2	's	's	POS
cord-016293-pyb00pt5	149	3	stated	state	VBN
cord-016293-pyb00pt5	149	4	goal	goal	NN
cord-016293-pyb00pt5	149	5	was	be	VBD
cord-016293-pyb00pt5	149	6	to	to	TO
cord-016293-pyb00pt5	149	7	lead	lead	VB
cord-016293-pyb00pt5	149	8	in	in	IN
cord-016293-pyb00pt5	149	9	the	the	DT
cord-016293-pyb00pt5	149	10	discovery	discovery	NN
cord-016293-pyb00pt5	149	11	of	of	IN
cord-016293-pyb00pt5	149	12	major	major	JJ
cord-016293-pyb00pt5	149	13	common	common	JJ
cord-016293-pyb00pt5	149	14	human	human	JJ
cord-016293-pyb00pt5	149	15	disease	disease	NN
cord-016293-pyb00pt5	149	16	genes	gene	NNS
cord-016293-pyb00pt5	149	17	and	and	CC
cord-016293-pyb00pt5	149	18	their	-PRON-	PRP$
cord-016293-pyb00pt5	149	19	related	related	JJ
cord-016293-pyb00pt5	149	20	pathways	pathway	NNS
cord-016293-pyb00pt5	149	21	.	.	.
cord-016293-pyb00pt5	150	1	The	the	DT
cord-016293-pyb00pt5	150	2	company	company	NN
cord-016293-pyb00pt5	150	3	discovered	discover	VBD
cord-016293-pyb00pt5	150	4	and	and	CC
cord-016293-pyb00pt5	150	5	sequenced	sequence	VBN
cord-016293-pyb00pt5	150	6	,	,	,
cord-016293-pyb00pt5	150	7	with	with	IN
cord-016293-pyb00pt5	150	8	its	-PRON-	PRP$
cord-016293-pyb00pt5	150	9	academic	academic	JJ
cord-016293-pyb00pt5	150	10	collaborators	collaborator	NNS
cord-016293-pyb00pt5	150	11	(	(	-LRB-
cord-016293-pyb00pt5	150	12	originally	originally	RB
cord-016293-pyb00pt5	150	13	Synteni	Synteni	NNP
cord-016293-pyb00pt5	150	14	from	from	IN
cord-016293-pyb00pt5	150	15	Pat	Pat	NNP
cord-016293-pyb00pt5	150	16	Brown	Brown	NNP
cord-016293-pyb00pt5	150	17	's	's	POS
cord-016293-pyb00pt5	150	18	lab	lab	NN
cord-016293-pyb00pt5	150	19	at	at	IN
cord-016293-pyb00pt5	150	20	Stanford	Stanford	NNP
cord-016293-pyb00pt5	150	21	)	)	-RRB-
cord-016293-pyb00pt5	150	22	,	,	,
cord-016293-pyb00pt5	150	23	a	a	DT
cord-016293-pyb00pt5	150	24	number	number	NN
cord-016293-pyb00pt5	150	25	of	of	IN
cord-016293-pyb00pt5	150	26	important	important	JJ
cord-016293-pyb00pt5	150	27	genes	gene	NNS
cord-016293-pyb00pt5	150	28	including	include	VBG
cord-016293-pyb00pt5	150	29	BRCA1	BRCA1	NNP
cord-016293-pyb00pt5	150	30	and	and	CC
cord-016293-pyb00pt5	150	31	BRCA2	brca2	XX
cord-016293-pyb00pt5	150	32	,	,	,
cord-016293-pyb00pt5	150	33	with	with	IN
cord-016293-pyb00pt5	150	34	Mary	Mary	NNP
cord-016293-pyb00pt5	150	35	Claire	Claire	NNP
cord-016293-pyb00pt5	150	36	King	King	NNP
cord-016293-pyb00pt5	150	37	,	,	,
cord-016293-pyb00pt5	150	38	epidemiologist	epidemiologist	NN
cord-016293-pyb00pt5	150	39	at	at	IN
cord-016293-pyb00pt5	150	40	UC	UC	NNP
cord-016293-pyb00pt5	150	41	-	-	HYPH
cord-016293-pyb00pt5	150	42	Berkeley	Berkeley	NNP
cord-016293-pyb00pt5	150	43	,	,	,
cord-016293-pyb00pt5	150	44	the	the	DT
cord-016293-pyb00pt5	150	45	genes	gene	NNS
cord-016293-pyb00pt5	150	46	linked	link	VBN
cord-016293-pyb00pt5	150	47	to	to	IN
cord-016293-pyb00pt5	150	48	breast	breast	NN
cord-016293-pyb00pt5	150	49	cancer	cancer	NN
cord-016293-pyb00pt5	150	50	in	in	IN
cord-016293-pyb00pt5	150	51	families	family	NNS
cord-016293-pyb00pt5	150	52	with	with	IN
cord-016293-pyb00pt5	150	53	a	a	DT
cord-016293-pyb00pt5	150	54	high	high	JJ
cord-016293-pyb00pt5	150	55	degree	degree	NN
cord-016293-pyb00pt5	150	56	of	of	IN
cord-016293-pyb00pt5	150	57	incidence	incidence	NN
cord-016293-pyb00pt5	150	58	before	before	IN
cord-016293-pyb00pt5	150	59	age	age	NN
cord-016293-pyb00pt5	150	60	45	45	CD
cord-016293-pyb00pt5	150	61	.	.	.
cord-016293-pyb00pt5	151	1	By	by	IN
cord-016293-pyb00pt5	151	2	1992	1992	CD
cord-016293-pyb00pt5	151	3	a	a	DT
cord-016293-pyb00pt5	151	4	low	low	JJ
cord-016293-pyb00pt5	151	5	-	-	HYPH
cord-016293-pyb00pt5	151	6	resolution	resolution	NN
cord-016293-pyb00pt5	151	7	genetic	genetic	JJ
cord-016293-pyb00pt5	151	8	linkage	linkage	NN
cord-016293-pyb00pt5	151	9	map	map	NN
cord-016293-pyb00pt5	151	10	of	of	IN
cord-016293-pyb00pt5	151	11	the	the	DT
cord-016293-pyb00pt5	151	12	entire	entire	JJ
cord-016293-pyb00pt5	151	13	human	human	JJ
cord-016293-pyb00pt5	151	14	genome	genome	NN
cord-016293-pyb00pt5	151	15	was	be	VBD
cord-016293-pyb00pt5	151	16	published	publish	VBN
cord-016293-pyb00pt5	151	17	and	and	CC
cord-016293-pyb00pt5	151	18	U.S.	U.S.	NNP
cord-016293-pyb00pt5	151	19	and	and	CC
cord-016293-pyb00pt5	151	20	French	french	JJ
cord-016293-pyb00pt5	151	21	teams	team	NNS
cord-016293-pyb00pt5	151	22	completed	complete	VBD
cord-016293-pyb00pt5	151	23	genetic	genetic	JJ
cord-016293-pyb00pt5	151	24	maps	map	NNS
cord-016293-pyb00pt5	151	25	of	of	IN
cord-016293-pyb00pt5	151	26	both	both	DT
cord-016293-pyb00pt5	151	27	mouse	mouse	NN
cord-016293-pyb00pt5	151	28	and	and	CC
cord-016293-pyb00pt5	151	29	man	man	NN
cord-016293-pyb00pt5	151	30	.	.	.
cord-016293-pyb00pt5	152	1	The	the	DT
cord-016293-pyb00pt5	152	2	mouse	mouse	NN
cord-016293-pyb00pt5	152	3	with	with	IN
cord-016293-pyb00pt5	152	4	an	an	DT
cord-016293-pyb00pt5	152	5	average	average	JJ
cord-016293-pyb00pt5	152	6	marker	marker	NN
cord-016293-pyb00pt5	152	7	spacing	spacing	NN
cord-016293-pyb00pt5	152	8	of	of	IN
cord-016293-pyb00pt5	152	9	4.3	4.3	CD
cord-016293-pyb00pt5	152	10	cM	cM	NNS
cord-016293-pyb00pt5	152	11	as	as	IN
cord-016293-pyb00pt5	152	12	determined	determine	VBN
cord-016293-pyb00pt5	152	13	by	by	IN
cord-016293-pyb00pt5	152	14	Eric	Eric	NNP
cord-016293-pyb00pt5	152	15	Lander	Lander	NNP
cord-016293-pyb00pt5	152	16	and	and	CC
cord-016293-pyb00pt5	152	17	colleagues	colleague	NNS
cord-016293-pyb00pt5	152	18	at	at	IN
cord-016293-pyb00pt5	152	19	Whitehead	Whitehead	NNP
cord-016293-pyb00pt5	152	20	and	and	CC
cord-016293-pyb00pt5	152	21	the	the	DT
cord-016293-pyb00pt5	152	22	human	human	NN
cord-016293-pyb00pt5	152	23	,	,	,
cord-016293-pyb00pt5	152	24	with	with	IN
cord-016293-pyb00pt5	152	25	an	an	DT
cord-016293-pyb00pt5	152	26	average	average	JJ
cord-016293-pyb00pt5	152	27	marker	marker	NN
cord-016293-pyb00pt5	152	28	spacing	spacing	NN
cord-016293-pyb00pt5	152	29	of	of	IN
cord-016293-pyb00pt5	152	30	5	5	CD
cord-016293-pyb00pt5	152	31	cM	cM	NNS
cord-016293-pyb00pt5	152	32	by	by	IN
cord-016293-pyb00pt5	152	33	Jean	Jean	NNP
cord-016293-pyb00pt5	152	34	Weissenbach	Weissenbach	NNP
cord-016293-pyb00pt5	152	35	and	and	CC
cord-016293-pyb00pt5	152	36	colleagues	colleague	NNS
cord-016293-pyb00pt5	152	37	at	at	IN
cord-016293-pyb00pt5	152	38	CEPH	CEPH	NNP
cord-016293-pyb00pt5	152	39	(	(	-LRB-
cord-016293-pyb00pt5	152	40	Centre	Centre	NNP
cord-016293-pyb00pt5	152	41	d'Etude	d'Etude	NNP
cord-016293-pyb00pt5	152	42	du	du	NNP
cord-016293-pyb00pt5	152	43	Polymorphisme	Polymorphisme	NNP
cord-016293-pyb00pt5	152	44	Humaine	Humaine	NNP
cord-016293-pyb00pt5	152	45	)	)	-RRB-
cord-016293-pyb00pt5	152	46	.	.	.
cord-016293-pyb00pt5	153	1	The	the	DT
cord-016293-pyb00pt5	153	2	latter	latter	JJ
cord-016293-pyb00pt5	153	3	institute	institute	NN
cord-016293-pyb00pt5	153	4	was	be	VBD
cord-016293-pyb00pt5	153	5	the	the	DT
cord-016293-pyb00pt5	153	6	subject	subject	NN
cord-016293-pyb00pt5	153	7	of	of	IN
cord-016293-pyb00pt5	153	8	a	a	DT
cord-016293-pyb00pt5	153	9	rather	rather	RB
cord-016293-pyb00pt5	153	10	scathing	scathing	JJ
cord-016293-pyb00pt5	153	11	book	book	NN
cord-016293-pyb00pt5	153	12	by	by	IN
cord-016293-pyb00pt5	153	13	Paul	Paul	NNP
cord-016293-pyb00pt5	153	14	Rabinow	Rabinow	NNP
cord-016293-pyb00pt5	153	15	(	(	-LRB-
cord-016293-pyb00pt5	153	16	1999	1999	CD
cord-016293-pyb00pt5	153	17	)	)	-RRB-
cord-016293-pyb00pt5	153	18	based	base	VBN
cord-016293-pyb00pt5	153	19	on	on	IN
cord-016293-pyb00pt5	153	20	what	what	WP
cord-016293-pyb00pt5	153	21	they	-PRON-	PRP
cord-016293-pyb00pt5	153	22	did	do	VBD
cord-016293-pyb00pt5	153	23	with	with	IN
cord-016293-pyb00pt5	153	24	this	this	DT
cord-016293-pyb00pt5	153	25	genome	genome	NN
cord-016293-pyb00pt5	153	26	map	map	NN
cord-016293-pyb00pt5	153	27	.	.	.
cord-016293-pyb00pt5	154	1	In	in	IN
cord-016293-pyb00pt5	154	2	1993	1993	CD
cord-016293-pyb00pt5	154	3	,	,	,
cord-016293-pyb00pt5	154	4	an	an	DT
cord-016293-pyb00pt5	154	5	American	american	JJ
cord-016293-pyb00pt5	154	6	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	154	7	company	company	NN
cord-016293-pyb00pt5	154	8	,	,	,
cord-016293-pyb00pt5	154	9	Millennium	Millennium	NNP
cord-016293-pyb00pt5	154	10	Pharmaceuticals	Pharmaceuticals	NNPS
cord-016293-pyb00pt5	154	11	,	,	,
cord-016293-pyb00pt5	154	12	and	and	CC
cord-016293-pyb00pt5	154	13	the	the	DT
cord-016293-pyb00pt5	154	14	CEPH	CEPH	NNP
cord-016293-pyb00pt5	154	15	,	,	,
cord-016293-pyb00pt5	154	16	developed	develop	VBD
cord-016293-pyb00pt5	154	17	plans	plan	NNS
cord-016293-pyb00pt5	154	18	for	for	IN
cord-016293-pyb00pt5	154	19	a	a	DT
cord-016293-pyb00pt5	154	20	collaborative	collaborative	JJ
cord-016293-pyb00pt5	154	21	effort	effort	NN
cord-016293-pyb00pt5	154	22	to	to	TO
cord-016293-pyb00pt5	154	23	discover	discover	VB
cord-016293-pyb00pt5	154	24	diabetes	diabetes	NN
cord-016293-pyb00pt5	154	25	genes	gene	NNS
cord-016293-pyb00pt5	154	26	.	.	.
cord-016293-pyb00pt5	155	1	The	the	DT
cord-016293-pyb00pt5	155	2	results	result	NNS
cord-016293-pyb00pt5	155	3	of	of	IN
cord-016293-pyb00pt5	155	4	this	this	DT
cord-016293-pyb00pt5	155	5	collaboration	collaboration	NN
cord-016293-pyb00pt5	155	6	could	could	MD
cord-016293-pyb00pt5	155	7	have	have	VB
cord-016293-pyb00pt5	155	8	been	be	VBN
cord-016293-pyb00pt5	155	9	medically	medically	RB
cord-016293-pyb00pt5	155	10	significant	significant	JJ
cord-016293-pyb00pt5	155	11	and	and	CC
cord-016293-pyb00pt5	155	12	financially	financially	RB
cord-016293-pyb00pt5	155	13	lucrative	lucrative	JJ
cord-016293-pyb00pt5	155	14	.	.	.
cord-016293-pyb00pt5	156	1	The	the	DT
cord-016293-pyb00pt5	156	2	two	two	CD
cord-016293-pyb00pt5	156	3	parties	party	NNS
cord-016293-pyb00pt5	156	4	had	have	VBD
cord-016293-pyb00pt5	156	5	agreed	agree	VBN
cord-016293-pyb00pt5	156	6	that	that	IN
cord-016293-pyb00pt5	156	7	CEPH	CEPH	NNP
cord-016293-pyb00pt5	156	8	would	would	MD
cord-016293-pyb00pt5	156	9	supply	supply	VB
cord-016293-pyb00pt5	156	10	Millennium	Millennium	NNP
cord-016293-pyb00pt5	156	11	with	with	IN
cord-016293-pyb00pt5	156	12	germplasm	germplasm	NN
cord-016293-pyb00pt5	156	13	collected	collect	VBN
cord-016293-pyb00pt5	156	14	from	from	IN
cord-016293-pyb00pt5	156	15	a	a	DT
cord-016293-pyb00pt5	156	16	large	large	JJ
cord-016293-pyb00pt5	156	17	coterie	coterie	NN
cord-016293-pyb00pt5	156	18	of	of	IN
cord-016293-pyb00pt5	156	19	French	french	JJ
cord-016293-pyb00pt5	156	20	families	family	NNS
cord-016293-pyb00pt5	156	21	,	,	,
cord-016293-pyb00pt5	156	22	and	and	CC
cord-016293-pyb00pt5	156	23	Millennium	Millennium	NNP
cord-016293-pyb00pt5	156	24	would	would	MD
cord-016293-pyb00pt5	156	25	supply	supply	VB
cord-016293-pyb00pt5	156	26	funding	funding	NN
cord-016293-pyb00pt5	156	27	and	and	CC
cord-016293-pyb00pt5	156	28	expertise	expertise	NN
cord-016293-pyb00pt5	156	29	in	in	IN
cord-016293-pyb00pt5	156	30	new	new	JJ
cord-016293-pyb00pt5	156	31	technologies	technology	NNS
cord-016293-pyb00pt5	156	32	to	to	TO
cord-016293-pyb00pt5	156	33	accelerate	accelerate	VB
cord-016293-pyb00pt5	156	34	the	the	DT
cord-016293-pyb00pt5	156	35	identification	identification	NN
cord-016293-pyb00pt5	156	36	of	of	IN
cord-016293-pyb00pt5	156	37	the	the	DT
cord-016293-pyb00pt5	156	38	genes	gene	NNS
cord-016293-pyb00pt5	156	39	,	,	,
cord-016293-pyb00pt5	156	40	terms	term	NNS
cord-016293-pyb00pt5	156	41	to	to	IN
cord-016293-pyb00pt5	156	42	which	which	WDT
cord-016293-pyb00pt5	156	43	the	the	DT
cord-016293-pyb00pt5	156	44	French	french	JJ
cord-016293-pyb00pt5	156	45	government	government	NN
cord-016293-pyb00pt5	156	46	had	have	VBD
cord-016293-pyb00pt5	156	47	agreed	agree	VBN
cord-016293-pyb00pt5	156	48	.	.	.
cord-016293-pyb00pt5	157	1	But	but	CC
cord-016293-pyb00pt5	157	2	in	in	IN
cord-016293-pyb00pt5	157	3	early	early	JJ
cord-016293-pyb00pt5	157	4	1994	1994	CD
cord-016293-pyb00pt5	157	5	,	,	,
cord-016293-pyb00pt5	157	6	just	just	RB
cord-016293-pyb00pt5	157	7	as	as	IN
cord-016293-pyb00pt5	157	8	the	the	DT
cord-016293-pyb00pt5	157	9	collaboration	collaboration	NN
cord-016293-pyb00pt5	157	10	was	be	VBD
cord-016293-pyb00pt5	157	11	to	to	TO
cord-016293-pyb00pt5	157	12	begin	begin	VB
cord-016293-pyb00pt5	157	13	,	,	,
cord-016293-pyb00pt5	157	14	the	the	DT
cord-016293-pyb00pt5	157	15	French	french	JJ
cord-016293-pyb00pt5	157	16	government	government	NN
cord-016293-pyb00pt5	157	17	cried	cry	VBD
cord-016293-pyb00pt5	157	18	halt	halt	VB
cord-016293-pyb00pt5	157	19	!	!	.
cord-016293-pyb00pt5	158	1	The	the	DT
cord-016293-pyb00pt5	158	2	government	government	NN
cord-016293-pyb00pt5	158	3	explained	explain	VBD
cord-016293-pyb00pt5	158	4	that	that	IN
cord-016293-pyb00pt5	158	5	the	the	DT
cord-016293-pyb00pt5	158	6	CEPH	CEPH	NNP
cord-016293-pyb00pt5	158	7	could	could	MD
cord-016293-pyb00pt5	158	8	not	not	RB
cord-016293-pyb00pt5	158	9	be	be	VB
cord-016293-pyb00pt5	158	10	permitted	permit	VBN
cord-016293-pyb00pt5	158	11	to	to	TO
cord-016293-pyb00pt5	158	12	give	give	VB
cord-016293-pyb00pt5	158	13	the	the	DT
cord-016293-pyb00pt5	158	14	Americans	Americans	NNPS
cord-016293-pyb00pt5	158	15	that	that	WDT
cord-016293-pyb00pt5	158	16	most	most	RBS
cord-016293-pyb00pt5	158	17	precious	precious	JJ
cord-016293-pyb00pt5	158	18	of	of	IN
cord-016293-pyb00pt5	158	19	substances	substance	NNS
cord-016293-pyb00pt5	158	20	for	for	IN
cord-016293-pyb00pt5	158	21	which	which	WDT
cord-016293-pyb00pt5	158	22	there	there	EX
cord-016293-pyb00pt5	158	23	was	be	VBD
cord-016293-pyb00pt5	158	24	no	no	DT
cord-016293-pyb00pt5	158	25	precedent	precedent	NN
cord-016293-pyb00pt5	158	26	in	in	IN
cord-016293-pyb00pt5	158	27	law	law	NN
cord-016293-pyb00pt5	158	28	-French	-french	CD
cord-016293-pyb00pt5	158	29	DNA	DNA	NNP
cord-016293-pyb00pt5	158	30	.	.	.
cord-016293-pyb00pt5	159	1	Rabinow	Rabinow	NNP
cord-016293-pyb00pt5	159	2	's	's	POS
cord-016293-pyb00pt5	159	3	book	book	NN
cord-016293-pyb00pt5	159	4	discusses	discuss	VBZ
cord-016293-pyb00pt5	159	5	the	the	DT
cord-016293-pyb00pt5	159	6	tangled	tangled	JJ
cord-016293-pyb00pt5	159	7	relations	relation	NNS
cord-016293-pyb00pt5	159	8	and	and	CC
cord-016293-pyb00pt5	159	9	conceptions	conception	NNS
cord-016293-pyb00pt5	159	10	such	such	JJ
cord-016293-pyb00pt5	159	11	as	as	IN
cord-016293-pyb00pt5	159	12	,	,	,
cord-016293-pyb00pt5	159	13	can	can	MD
cord-016293-pyb00pt5	159	14	a	a	DT
cord-016293-pyb00pt5	159	15	country	country	NN
cord-016293-pyb00pt5	159	16	be	be	VB
cord-016293-pyb00pt5	159	17	said	say	VBN
cord-016293-pyb00pt5	159	18	to	to	TO
cord-016293-pyb00pt5	159	19	have	have	VB
cord-016293-pyb00pt5	159	20	its	-PRON-	PRP$
cord-016293-pyb00pt5	159	21	own	own	JJ
cord-016293-pyb00pt5	159	22	genetic	genetic	JJ
cord-016293-pyb00pt5	159	23	material	material	NN
cord-016293-pyb00pt5	159	24	,	,	,
cord-016293-pyb00pt5	159	25	the	the	DT
cord-016293-pyb00pt5	159	26	first	first	JJ
cord-016293-pyb00pt5	159	27	but	but	CC
cord-016293-pyb00pt5	159	28	hardly	hardly	RB
cord-016293-pyb00pt5	159	29	the	the	DT
cord-016293-pyb00pt5	159	30	last	last	JJ
cord-016293-pyb00pt5	159	31	Franco	Franco	NNP
cord-016293-pyb00pt5	159	32	-	-	HYPH
cord-016293-pyb00pt5	159	33	American	american	JJ
cord-016293-pyb00pt5	159	34	disavowal	disavowal	NN
cord-016293-pyb00pt5	159	35	of	of	IN
cord-016293-pyb00pt5	159	36	détente	détente	NN
cord-016293-pyb00pt5	159	37	(	(	-LRB-
cord-016293-pyb00pt5	159	38	Paul	Paul	NNP
cord-016293-pyb00pt5	159	39	Rabinow	Rabinow	NNP
cord-016293-pyb00pt5	159	40	,	,	,
cord-016293-pyb00pt5	159	41	1999	1999	CD
cord-016293-pyb00pt5	159	42	)	)	-RRB-
cord-016293-pyb00pt5	159	43	.	.	.
cord-016293-pyb00pt5	160	1	The	the	DT
cord-016293-pyb00pt5	160	2	latest	late	JJS
cord-016293-pyb00pt5	160	3	facilities	facility	NNS
cord-016293-pyb00pt5	160	4	such	such	JJ
cord-016293-pyb00pt5	160	5	as	as	IN
cord-016293-pyb00pt5	160	6	the	the	DT
cord-016293-pyb00pt5	160	7	Joint	Joint	NNP
cord-016293-pyb00pt5	160	8	Genome	Genome	NNP
cord-016293-pyb00pt5	160	9	Institute	Institute	NNP
cord-016293-pyb00pt5	160	10	(	(	-LRB-
cord-016293-pyb00pt5	160	11	JGI	JGI	NNP
cord-016293-pyb00pt5	160	12	)	)	-RRB-
cord-016293-pyb00pt5	160	13	,	,	,
cord-016293-pyb00pt5	160	14	Walnut	Walnut	NNP
cord-016293-pyb00pt5	160	15	Creek	Creek	NNP
cord-016293-pyb00pt5	160	16	,	,	,
cord-016293-pyb00pt5	160	17	CA	CA	NNP
cord-016293-pyb00pt5	160	18	are	be	VBP
cord-016293-pyb00pt5	160	19	now	now	RB
cord-016293-pyb00pt5	160	20	able	able	JJ
cord-016293-pyb00pt5	160	21	to	to	TO
cord-016293-pyb00pt5	160	22	sequence	sequence	VB
cord-016293-pyb00pt5	160	23	up	up	RP
cord-016293-pyb00pt5	160	24	to	to	IN
cord-016293-pyb00pt5	160	25	10Mb	10mb	CD
cord-016293-pyb00pt5	160	26	per	per	IN
cord-016293-pyb00pt5	160	27	day	day	NN
cord-016293-pyb00pt5	160	28	which	which	WDT
cord-016293-pyb00pt5	160	29	makes	make	VBZ
cord-016293-pyb00pt5	160	30	it	-PRON-	PRP
cord-016293-pyb00pt5	160	31	possible	possible	JJ
cord-016293-pyb00pt5	160	32	to	to	TO
cord-016293-pyb00pt5	160	33	sequence	sequence	VB
cord-016293-pyb00pt5	160	34	whole	whole	JJ
cord-016293-pyb00pt5	160	35	microbial	microbial	JJ
cord-016293-pyb00pt5	160	36	genomes	genome	NNS
cord-016293-pyb00pt5	160	37	within	within	IN
cord-016293-pyb00pt5	160	38	a	a	DT
cord-016293-pyb00pt5	160	39	day	day	NN
cord-016293-pyb00pt5	160	40	.	.	.
cord-016293-pyb00pt5	161	1	Technologies	technology	NNS
cord-016293-pyb00pt5	161	2	currently	currently	RB
cord-016293-pyb00pt5	161	3	under	under	IN
cord-016293-pyb00pt5	161	4	development	development	NN
cord-016293-pyb00pt5	161	5	will	will	MD
cord-016293-pyb00pt5	161	6	probably	probably	RB
cord-016293-pyb00pt5	161	7	increase	increase	VB
cord-016293-pyb00pt5	161	8	this	this	DT
cord-016293-pyb00pt5	161	9	capacity	capacity	NN
cord-016293-pyb00pt5	161	10	yet	yet	RB
cord-016293-pyb00pt5	161	11	further	far	RBR
cord-016293-pyb00pt5	161	12	through	through	IN
cord-016293-pyb00pt5	161	13	massively	massively	RB
cord-016293-pyb00pt5	161	14	parallel	parallel	JJ
cord-016293-pyb00pt5	161	15	sequencing	sequencing	NN
cord-016293-pyb00pt5	161	16	and/or	and/or	CC
cord-016293-pyb00pt5	161	17	microfluidic	microfluidic	JJ
cord-016293-pyb00pt5	161	18	processing	processing	NN
cord-016293-pyb00pt5	161	19	making	make	VBG
cord-016293-pyb00pt5	161	20	it	-PRON-	PRP
cord-016293-pyb00pt5	161	21	possible	possible	JJ
cord-016293-pyb00pt5	161	22	to	to	TO
cord-016293-pyb00pt5	161	23	sequence	sequence	VB
cord-016293-pyb00pt5	161	24	multiple	multiple	JJ
cord-016293-pyb00pt5	161	25	genotypes	genotype	NNS
cord-016293-pyb00pt5	161	26	from	from	IN
cord-016293-pyb00pt5	161	27	several	several	JJ
cord-016293-pyb00pt5	161	28	species	specie	NNS
cord-016293-pyb00pt5	161	29	.	.	.
cord-016293-pyb00pt5	162	1	Nineteen	nineteen	CD
cord-016293-pyb00pt5	162	2	ninety	ninety	CD
cord-016293-pyb00pt5	162	3	-	-	HYPH
cord-016293-pyb00pt5	162	4	two	two	CD
cord-016293-pyb00pt5	162	5	saw	see	VBD
cord-016293-pyb00pt5	162	6	one	one	CD
cord-016293-pyb00pt5	162	7	of	of	IN
cord-016293-pyb00pt5	162	8	the	the	DT
cord-016293-pyb00pt5	162	9	first	first	JJ
cord-016293-pyb00pt5	162	10	shakeups	shakeup	NNS
cord-016293-pyb00pt5	162	11	in	in	IN
cord-016293-pyb00pt5	162	12	the	the	DT
cord-016293-pyb00pt5	162	13	progress	progress	NN
cord-016293-pyb00pt5	162	14	of	of	IN
cord-016293-pyb00pt5	162	15	the	the	DT
cord-016293-pyb00pt5	162	16	HGP	HGP	NNP
cord-016293-pyb00pt5	162	17	.	.	.
cord-016293-pyb00pt5	163	1	That	that	DT
cord-016293-pyb00pt5	163	2	was	be	VBD
cord-016293-pyb00pt5	163	3	the	the	DT
cord-016293-pyb00pt5	163	4	year	year	NN
cord-016293-pyb00pt5	163	5	that	that	WDT
cord-016293-pyb00pt5	163	6	the	the	DT
cord-016293-pyb00pt5	163	7	first	first	JJ
cord-016293-pyb00pt5	163	8	major	major	JJ
cord-016293-pyb00pt5	163	9	outsider	outsider	NN
cord-016293-pyb00pt5	163	10	entered	enter	VBD
cord-016293-pyb00pt5	163	11	the	the	DT
cord-016293-pyb00pt5	163	12	race	race	NN
cord-016293-pyb00pt5	163	13	when	when	WRB
cord-016293-pyb00pt5	163	14	Britain	Britain	NNP
cord-016293-pyb00pt5	163	15	's	's	POS
cord-016293-pyb00pt5	163	16	Wellcome	Wellcome	NNP
cord-016293-pyb00pt5	163	17	Trust	Trust	NNP
cord-016293-pyb00pt5	163	18	plunked	plunk	VBD
cord-016293-pyb00pt5	163	19	down	down	RP
cord-016293-pyb00pt5	163	20	$	$	$
cord-016293-pyb00pt5	163	21	95	95	CD
cord-016293-pyb00pt5	163	22	million	million	CD
cord-016293-pyb00pt5	163	23	to	to	TO
cord-016293-pyb00pt5	163	24	join	join	VB
cord-016293-pyb00pt5	163	25	the	the	DT
cord-016293-pyb00pt5	163	26	HGP	hgp	NN
cord-016293-pyb00pt5	163	27	.	.	.
cord-016293-pyb00pt5	164	1	This	this	DT
cord-016293-pyb00pt5	164	2	caused	cause	VBD
cord-016293-pyb00pt5	164	3	a	a	DT
cord-016293-pyb00pt5	164	4	mere	mere	JJ
cord-016293-pyb00pt5	164	5	ripple	ripple	NN
cord-016293-pyb00pt5	164	6	while	while	IN
cord-016293-pyb00pt5	164	7	the	the	DT
cord-016293-pyb00pt5	164	8	principal	principal	JJ
cord-016293-pyb00pt5	164	9	shake	shake	NN
cord-016293-pyb00pt5	164	10	-	-	HYPH
cord-016293-pyb00pt5	164	11	ups	up	NNS
cord-016293-pyb00pt5	164	12	occurred	occur	VBD
cord-016293-pyb00pt5	164	13	stateside	stateside	RB
cord-016293-pyb00pt5	164	14	.	.	.
cord-016293-pyb00pt5	165	1	Much	much	JJ
cord-016293-pyb00pt5	165	2	of	of	IN
cord-016293-pyb00pt5	165	3	the	the	DT
cord-016293-pyb00pt5	165	4	debate	debate	NN
cord-016293-pyb00pt5	165	5	and	and	CC
cord-016293-pyb00pt5	165	6	subsequently	subsequently	RB
cord-016293-pyb00pt5	165	7	the	the	DT
cord-016293-pyb00pt5	165	8	direction	direction	NN
cord-016293-pyb00pt5	165	9	all	all	PDT
cord-016293-pyb00pt5	165	10	the	the	DT
cord-016293-pyb00pt5	165	11	way	way	NN
cord-016293-pyb00pt5	165	12	through	through	IN
cord-016293-pyb00pt5	165	13	the	the	DT
cord-016293-pyb00pt5	165	14	HGP	hgp	NN
cord-016293-pyb00pt5	165	15	process	process	NN
cord-016293-pyb00pt5	165	16	was	be	VBD
cord-016293-pyb00pt5	165	17	shaped	shape	VBN
cord-016293-pyb00pt5	165	18	by	by	IN
cord-016293-pyb00pt5	165	19	the	the	DT
cord-016293-pyb00pt5	165	20	personalities	personality	NNS
cord-016293-pyb00pt5	165	21	involved	involve	VBN
cord-016293-pyb00pt5	165	22	.	.	.
cord-016293-pyb00pt5	166	1	As	as	IN
cord-016293-pyb00pt5	166	2	noted	note	VBD
cord-016293-pyb00pt5	166	3	the	the	DT
cord-016293-pyb00pt5	166	4	application	application	NN
cord-016293-pyb00pt5	166	5	of	of	IN
cord-016293-pyb00pt5	166	6	one	one	CD
cord-016293-pyb00pt5	166	7	of	of	IN
cord-016293-pyb00pt5	166	8	the	the	DT
cord-016293-pyb00pt5	166	9	innovative	innovative	JJ
cord-016293-pyb00pt5	166	10	techniques	technique	NNS
cord-016293-pyb00pt5	166	11	,	,	,
cord-016293-pyb00pt5	166	12	namely	namely	RB
cord-016293-pyb00pt5	166	13	ESTs	ESTs	NNP
cord-016293-pyb00pt5	166	14	,	,	,
cord-016293-pyb00pt5	166	15	to	to	TO
cord-016293-pyb00pt5	166	16	do	do	VB
cord-016293-pyb00pt5	166	17	an	an	DT
cord-016293-pyb00pt5	166	18	end	end	NN
cord-016293-pyb00pt5	166	19	run	run	VBN
cord-016293-pyb00pt5	166	20	on	on	IN
cord-016293-pyb00pt5	166	21	patenting	patent	VBG
cord-016293-pyb00pt5	166	22	introduced	introduce	VBN
cord-016293-pyb00pt5	166	23	one	one	CD
cord-016293-pyb00pt5	166	24	of	of	IN
cord-016293-pyb00pt5	166	25	those	those	DT
cord-016293-pyb00pt5	166	26	major	major	JJ
cord-016293-pyb00pt5	166	27	players	player	NNS
cord-016293-pyb00pt5	166	28	to	to	IN
cord-016293-pyb00pt5	166	29	the	the	DT
cord-016293-pyb00pt5	166	30	fray	fray	NN
cord-016293-pyb00pt5	166	31	,	,	,
cord-016293-pyb00pt5	166	32	Craig	Craig	NNP
cord-016293-pyb00pt5	166	33	Venter	Venter	NNP
cord-016293-pyb00pt5	166	34	.	.	.
cord-016293-pyb00pt5	167	1	Venter	Venter	NNP
cord-016293-pyb00pt5	167	2	,	,	,
cord-016293-pyb00pt5	167	3	the	the	DT
cord-016293-pyb00pt5	167	4	high	high	JJ
cord-016293-pyb00pt5	167	5	school	school	NN
cord-016293-pyb00pt5	167	6	drop	drop	NN
cord-016293-pyb00pt5	167	7	out	out	RP
cord-016293-pyb00pt5	167	8	who	who	WP
cord-016293-pyb00pt5	167	9	reached	reach	VBD
cord-016293-pyb00pt5	167	10	the	the	DT
cord-016293-pyb00pt5	167	11	age	age	NN
cord-016293-pyb00pt5	167	12	of	of	IN
cord-016293-pyb00pt5	167	13	majority	majority	NN
cord-016293-pyb00pt5	167	14	in	in	IN
cord-016293-pyb00pt5	167	15	the	the	DT
cord-016293-pyb00pt5	167	16	killing	kill	VBG
cord-016293-pyb00pt5	167	17	fields	field	NNS
cord-016293-pyb00pt5	167	18	of	of	IN
cord-016293-pyb00pt5	167	19	Vietnam	Vietnam	NNP
cord-016293-pyb00pt5	167	20	was	be	VBD
cord-016293-pyb00pt5	167	21	to	to	TO
cord-016293-pyb00pt5	167	22	play	play	VB
cord-016293-pyb00pt5	167	23	a	a	DT
cord-016293-pyb00pt5	167	24	pivotal	pivotal	JJ
cord-016293-pyb00pt5	167	25	role	role	NN
cord-016293-pyb00pt5	167	26	in	in	IN
cord-016293-pyb00pt5	167	27	a	a	DT
cord-016293-pyb00pt5	167	28	more	more	RBR
cord-016293-pyb00pt5	167	29	"	"	``
cord-016293-pyb00pt5	167	30	civilized	civilized	JJ
cord-016293-pyb00pt5	167	31	"	"	''
cord-016293-pyb00pt5	167	32	but	but	CC
cord-016293-pyb00pt5	167	33	no	no	DT
cord-016293-pyb00pt5	167	34	less	less	RBR
cord-016293-pyb00pt5	167	35	combative	combative	JJ
cord-016293-pyb00pt5	167	36	field	field	NN
cord-016293-pyb00pt5	167	37	of	of	IN
cord-016293-pyb00pt5	167	38	human	human	JJ
cord-016293-pyb00pt5	167	39	endeavor	endeavor	NN
cord-016293-pyb00pt5	167	40	.	.	.
cord-016293-pyb00pt5	168	1	He	-PRON-	PRP
cord-016293-pyb00pt5	168	2	came	come	VBD
cord-016293-pyb00pt5	168	3	onto	onto	IN
cord-016293-pyb00pt5	168	4	the	the	DT
cord-016293-pyb00pt5	168	5	world	world	NN
cord-016293-pyb00pt5	168	6	stage	stage	NN
cord-016293-pyb00pt5	168	7	through	through	IN
cord-016293-pyb00pt5	168	8	his	-PRON-	PRP$
cord-016293-pyb00pt5	168	9	initial	initial	JJ
cord-016293-pyb00pt5	168	10	work	work	NN
cord-016293-pyb00pt5	168	11	on	on	IN
cord-016293-pyb00pt5	168	12	ESTs	est	NNS
cord-016293-pyb00pt5	168	13	while	while	IN
cord-016293-pyb00pt5	168	14	at	at	IN
cord-016293-pyb00pt5	168	15	the	the	DT
cord-016293-pyb00pt5	168	16	National	National	NNP
cord-016293-pyb00pt5	168	17	Institute	Institute	NNP
cord-016293-pyb00pt5	168	18	of	of	IN
cord-016293-pyb00pt5	168	19	Neurological	Neurological	NNP
cord-016293-pyb00pt5	168	20	Disorders	Disorders	NNPS
cord-016293-pyb00pt5	168	21	and	and	CC
cord-016293-pyb00pt5	168	22	Stroke	Stroke	NNP
cord-016293-pyb00pt5	168	23	(	(	-LRB-
cord-016293-pyb00pt5	168	24	NINDS	NINDS	NNP
cord-016293-pyb00pt5	168	25	)	)	-RRB-
cord-016293-pyb00pt5	168	26	from	from	IN
cord-016293-pyb00pt5	168	27	1984	1984	CD
cord-016293-pyb00pt5	168	28	to	to	IN
cord-016293-pyb00pt5	168	29	1992	1992	CD
cord-016293-pyb00pt5	168	30	.	.	.
cord-016293-pyb00pt5	169	1	He	-PRON-	PRP
cord-016293-pyb00pt5	169	2	noted	note	VBD
cord-016293-pyb00pt5	169	3	in	in	IN
cord-016293-pyb00pt5	169	4	an	an	DT
cord-016293-pyb00pt5	169	5	interview	interview	NN
cord-016293-pyb00pt5	169	6	with	with	IN
cord-016293-pyb00pt5	169	7	The	the	DT
cord-016293-pyb00pt5	169	8	Scientist	Scientist	NNP
cord-016293-pyb00pt5	169	9	magazine	magazine	NN
cord-016293-pyb00pt5	169	10	in	in	IN
cord-016293-pyb00pt5	169	11	1995	1995	CD
cord-016293-pyb00pt5	169	12	,	,	,
cord-016293-pyb00pt5	169	13	that	that	IN
cord-016293-pyb00pt5	169	14	there	there	EX
cord-016293-pyb00pt5	169	15	was	be	VBD
cord-016293-pyb00pt5	169	16	a	a	DT
cord-016293-pyb00pt5	169	17	degree	degree	NN
cord-016293-pyb00pt5	169	18	of	of	IN
cord-016293-pyb00pt5	169	19	ambiguity	ambiguity	NN
cord-016293-pyb00pt5	169	20	at	at	IN
cord-016293-pyb00pt5	169	21	NINDS	NINDS	NNP
cord-016293-pyb00pt5	169	22	about	about	IN
cord-016293-pyb00pt5	169	23	his	-PRON-	PRP$
cord-016293-pyb00pt5	169	24	venturing	venture	VBG
cord-016293-pyb00pt5	169	25	into	into	IN
cord-016293-pyb00pt5	169	26	the	the	DT
cord-016293-pyb00pt5	169	27	field	field	NN
cord-016293-pyb00pt5	169	28	of	of	IN
cord-016293-pyb00pt5	169	29	genomics	genomic	NNS
cord-016293-pyb00pt5	169	30	,	,	,
cord-016293-pyb00pt5	169	31	while	while	IN
cord-016293-pyb00pt5	169	32	they	-PRON-	PRP
cord-016293-pyb00pt5	169	33	liked	like	VBD
cord-016293-pyb00pt5	169	34	the	the	DT
cord-016293-pyb00pt5	169	35	prestige	prestige	NN
cord-016293-pyb00pt5	169	36	of	of	IN
cord-016293-pyb00pt5	169	37	hosting	host	VBG
cord-016293-pyb00pt5	169	38	one	one	CD
cord-016293-pyb00pt5	169	39	of	of	IN
cord-016293-pyb00pt5	169	40	the	the	DT
cord-016293-pyb00pt5	169	41	leaders	leader	NNS
cord-016293-pyb00pt5	169	42	and	and	CC
cord-016293-pyb00pt5	169	43	innovators	innovator	NNS
cord-016293-pyb00pt5	169	44	in	in	IN
cord-016293-pyb00pt5	169	45	his	-PRON-	PRP$
cord-016293-pyb00pt5	169	46	newly	newly	RB
cord-016293-pyb00pt5	169	47	emerging	emerging	JJ
cord-016293-pyb00pt5	169	48	field	field	NN
cord-016293-pyb00pt5	169	49	,	,	,
cord-016293-pyb00pt5	169	50	they	-PRON-	PRP
cord-016293-pyb00pt5	169	51	were	be	VBD
cord-016293-pyb00pt5	169	52	concerned	concerned	JJ
cord-016293-pyb00pt5	169	53	about	about	IN
cord-016293-pyb00pt5	169	54	him	-PRON-	PRP
cord-016293-pyb00pt5	169	55	moving	move	VBG
cord-016293-pyb00pt5	169	56	outside	outside	IN
cord-016293-pyb00pt5	169	57	the	the	DT
cord-016293-pyb00pt5	169	58	NIND	NIND	NNP
cord-016293-pyb00pt5	169	59	purview	purview	NN
cord-016293-pyb00pt5	169	60	of	of	IN
cord-016293-pyb00pt5	169	61	the	the	DT
cord-016293-pyb00pt5	169	62	human	human	JJ
cord-016293-pyb00pt5	169	63	brain	brain	NN
cord-016293-pyb00pt5	169	64	and	and	CC
cord-016293-pyb00pt5	169	65	nervous	nervous	JJ
cord-016293-pyb00pt5	169	66	system	system	NN
cord-016293-pyb00pt5	169	67	.	.	.
cord-016293-pyb00pt5	170	1	Ultimately	ultimately	RB
cord-016293-pyb00pt5	170	2	,	,	,
cord-016293-pyb00pt5	170	3	while	while	IN
cord-016293-pyb00pt5	170	4	he	-PRON-	PRP
cord-016293-pyb00pt5	170	5	proclaimed	proclaim	VBD
cord-016293-pyb00pt5	170	6	to	to	IN
cord-016293-pyb00pt5	170	7	like	like	VB
cord-016293-pyb00pt5	170	8	the	the	DT
cord-016293-pyb00pt5	170	9	security	security	NN
cord-016293-pyb00pt5	170	10	and	and	CC
cord-016293-pyb00pt5	170	11	service	service	NN
cord-016293-pyb00pt5	170	12	infrastructure	infrastructure	NN
cord-016293-pyb00pt5	170	13	this	this	DT
cord-016293-pyb00pt5	170	14	institute	institute	NN
cord-016293-pyb00pt5	170	15	afforded	afford	VBD
cord-016293-pyb00pt5	170	16	him	-PRON-	PRP
cord-016293-pyb00pt5	170	17	,	,	,
cord-016293-pyb00pt5	170	18	that	that	DT
cord-016293-pyb00pt5	170	19	same	same	JJ
cord-016293-pyb00pt5	170	20	system	system	NN
cord-016293-pyb00pt5	170	21	became	become	VBD
cord-016293-pyb00pt5	170	22	too	too	RB
cord-016293-pyb00pt5	170	23	restrictive	restrictive	JJ
cord-016293-pyb00pt5	170	24	for	for	IN
cord-016293-pyb00pt5	170	25	his	-PRON-	PRP$
cord-016293-pyb00pt5	170	26	interests	interest	NNS
cord-016293-pyb00pt5	170	27	and	and	CC
cord-016293-pyb00pt5	170	28	talent	talent	NN
cord-016293-pyb00pt5	170	29	.	.	.
cord-016293-pyb00pt5	171	1	He	-PRON-	PRP
cord-016293-pyb00pt5	171	2	wanted	want	VBD
cord-016293-pyb00pt5	171	3	the	the	DT
cord-016293-pyb00pt5	171	4	whole	whole	JJ
cord-016293-pyb00pt5	171	5	canvas	canvas	NN
cord-016293-pyb00pt5	171	6	of	of	IN
cord-016293-pyb00pt5	171	7	human	human	JJ
cord-016293-pyb00pt5	171	8	-	-	HYPH
cord-016293-pyb00pt5	171	9	gene	gene	NN
cord-016293-pyb00pt5	171	10	expression	expression	NN
cord-016293-pyb00pt5	171	11	to	to	TO
cord-016293-pyb00pt5	171	12	be	be	VB
cord-016293-pyb00pt5	171	13	his	-PRON-	PRP$
cord-016293-pyb00pt5	171	14	universe	universe	NN
cord-016293-pyb00pt5	171	15	,	,	,
cord-016293-pyb00pt5	171	16	not	not	RB
cord-016293-pyb00pt5	171	17	just	just	RB
cord-016293-pyb00pt5	171	18	what	what	WP
cord-016293-pyb00pt5	171	19	was	be	VBD
cord-016293-pyb00pt5	171	20	confined	confine	VBN
cord-016293-pyb00pt5	171	21	to	to	IN
cord-016293-pyb00pt5	171	22	the	the	DT
cord-016293-pyb00pt5	171	23	central	central	JJ
cord-016293-pyb00pt5	171	24	nervous	nervous	JJ
cord-016293-pyb00pt5	171	25	system	system	NN
cord-016293-pyb00pt5	171	26	.	.	.
cord-016293-pyb00pt5	172	1	He	-PRON-	PRP
cord-016293-pyb00pt5	172	2	was	be	VBD
cord-016293-pyb00pt5	172	3	becoming	become	VBG
cord-016293-pyb00pt5	172	4	more	more	RBR
cord-016293-pyb00pt5	172	5	interested	interested	JJ
cord-016293-pyb00pt5	172	6	in	in	IN
cord-016293-pyb00pt5	172	7	taking	take	VBG
cord-016293-pyb00pt5	172	8	a	a	DT
cord-016293-pyb00pt5	172	9	whole	whole	JJ
cord-016293-pyb00pt5	172	10	genome	genome	NN
cord-016293-pyb00pt5	172	11	approach	approach	NN
cord-016293-pyb00pt5	172	12	to	to	IN
cord-016293-pyb00pt5	172	13	understanding	understand	VBG
cord-016293-pyb00pt5	172	14	the	the	DT
cord-016293-pyb00pt5	172	15	overall	overall	JJ
cord-016293-pyb00pt5	172	16	structure	structure	NN
cord-016293-pyb00pt5	172	17	of	of	IN
cord-016293-pyb00pt5	172	18	genomes	genome	NNS
cord-016293-pyb00pt5	172	19	and	and	CC
cord-016293-pyb00pt5	172	20	genome	genome	NN
cord-016293-pyb00pt5	172	21	evolution	evolution	NN
cord-016293-pyb00pt5	172	22	,	,	,
cord-016293-pyb00pt5	172	23	which	which	WDT
cord-016293-pyb00pt5	172	24	was	be	VBD
cord-016293-pyb00pt5	172	25	much	much	RB
cord-016293-pyb00pt5	172	26	broader	broad	JJR
cord-016293-pyb00pt5	172	27	than	than	IN
cord-016293-pyb00pt5	172	28	the	the	DT
cord-016293-pyb00pt5	172	29	mission	mission	NN
cord-016293-pyb00pt5	172	30	of	of	IN
cord-016293-pyb00pt5	172	31	NINDS	NINDS	NNP
cord-016293-pyb00pt5	172	32	.	.	.
cord-016293-pyb00pt5	173	1	He	-PRON-	PRP
cord-016293-pyb00pt5	173	2	noted	note	VBD
cord-016293-pyb00pt5	173	3	,	,	,
cord-016293-pyb00pt5	173	4	with	with	IN
cord-016293-pyb00pt5	173	5	some	some	DT
cord-016293-pyb00pt5	173	6	irony	irony	NN
cord-016293-pyb00pt5	173	7	,	,	,
cord-016293-pyb00pt5	173	8	in	in	IN
cord-016293-pyb00pt5	173	9	later	later	JJ
cord-016293-pyb00pt5	173	10	years	year	NNS
cord-016293-pyb00pt5	173	11	that	that	IN
cord-016293-pyb00pt5	173	12	the	the	DT
cord-016293-pyb00pt5	173	13	then	then	RB
cord-016293-pyb00pt5	173	14	current	current	JJ
cord-016293-pyb00pt5	173	15	NIH	NIH	NNP
cord-016293-pyb00pt5	173	16	director	director	NN
cord-016293-pyb00pt5	173	17	Harold	Harold	NNP
cord-016293-pyb00pt5	173	18	Varmus	Varmus	NNP
cord-016293-pyb00pt5	173	19	had	have	VBD
cord-016293-pyb00pt5	173	20	wished	wish	VBN
cord-016293-pyb00pt5	173	21	in	in	IN
cord-016293-pyb00pt5	173	22	hindsight	hindsight	NN
cord-016293-pyb00pt5	173	23	that	that	IN
cord-016293-pyb00pt5	173	24	NIH	NIH	NNP
cord-016293-pyb00pt5	173	25	had	have	VBD
cord-016293-pyb00pt5	173	26	pushed	push	VBN
cord-016293-pyb00pt5	173	27	to	to	TO
cord-016293-pyb00pt5	173	28	do	do	VB
cord-016293-pyb00pt5	173	29	a	a	DT
cord-016293-pyb00pt5	173	30	similar	similar	JJ
cord-016293-pyb00pt5	173	31	database	database	NN
cord-016293-pyb00pt5	173	32	in	in	IN
cord-016293-pyb00pt5	173	33	the	the	DT
cord-016293-pyb00pt5	173	34	public	public	JJ
cord-016293-pyb00pt5	173	35	domain	domain	NN
cord-016293-pyb00pt5	173	36	,	,	,
cord-016293-pyb00pt5	173	37	clearly	clearly	RB
cord-016293-pyb00pt5	173	38	in	in	IN
cord-016293-pyb00pt5	173	39	Venter	Venter	NNP
cord-016293-pyb00pt5	173	40	's	's	POS
cord-016293-pyb00pt5	173	41	opinion	opinion	NN
cord-016293-pyb00pt5	174	1	Varmus	Varmus	NNP
cord-016293-pyb00pt5	174	2	was	be	VBD
cord-016293-pyb00pt5	174	3	in	in	IN
cord-016293-pyb00pt5	174	4	need	need	NN
cord-016293-pyb00pt5	174	5	of	of	IN
cord-016293-pyb00pt5	174	6	a	a	DT
cord-016293-pyb00pt5	174	7	refresher	refresher	NN
cord-016293-pyb00pt5	174	8	course	course	NN
cord-016293-pyb00pt5	174	9	in	in	IN
cord-016293-pyb00pt5	174	10	history	history	NN
cord-016293-pyb00pt5	174	11	!	!	.
cord-016293-pyb00pt5	175	1	Bernadine	Bernadine	NNP
cord-016293-pyb00pt5	175	2	Healy	Healy	NNP
cord-016293-pyb00pt5	175	3	,	,	,
cord-016293-pyb00pt5	175	4	NIH	NIH	NNP
cord-016293-pyb00pt5	175	5	director	director	NN
cord-016293-pyb00pt5	175	6	in	in	IN
cord-016293-pyb00pt5	175	7	1994	1994	CD
cord-016293-pyb00pt5	175	8	,	,	,
cord-016293-pyb00pt5	175	9	was	be	VBD
cord-016293-pyb00pt5	175	10	one	one	CD
cord-016293-pyb00pt5	175	11	of	of	IN
cord-016293-pyb00pt5	175	12	the	the	DT
cord-016293-pyb00pt5	175	13	few	few	JJ
cord-016293-pyb00pt5	175	14	in	in	IN
cord-016293-pyb00pt5	175	15	a	a	DT
cord-016293-pyb00pt5	175	16	leadership	leadership	NN
cord-016293-pyb00pt5	175	17	role	role	NN
cord-016293-pyb00pt5	175	18	who	who	WP
cord-016293-pyb00pt5	175	19	saw	see	VBD
cord-016293-pyb00pt5	175	20	the	the	DT
cord-016293-pyb00pt5	175	21	technical	technical	JJ
cord-016293-pyb00pt5	175	22	and	and	CC
cord-016293-pyb00pt5	175	23	fiscal	fiscal	JJ
cord-016293-pyb00pt5	175	24	promise	promise	NN
cord-016293-pyb00pt5	175	25	of	of	IN
cord-016293-pyb00pt5	175	26	Venter	Venter	NNP
cord-016293-pyb00pt5	175	27	's	's	POS
cord-016293-pyb00pt5	175	28	work	work	NN
cord-016293-pyb00pt5	175	29	and	and	CC
cord-016293-pyb00pt5	175	30	,	,	,
cord-016293-pyb00pt5	175	31	like	like	IN
cord-016293-pyb00pt5	175	32	all	all	DT
cord-016293-pyb00pt5	175	33	good	good	JJ
cord-016293-pyb00pt5	175	34	administrators	administrator	NNS
cord-016293-pyb00pt5	175	35	,	,	,
cord-016293-pyb00pt5	175	36	it	-PRON-	PRP
cord-016293-pyb00pt5	175	37	also	also	RB
cord-016293-pyb00pt5	175	38	presented	present	VBD
cord-016293-pyb00pt5	175	39	an	an	DT
cord-016293-pyb00pt5	175	40	opportunity	opportunity	NN
cord-016293-pyb00pt5	175	41	to	to	TO
cord-016293-pyb00pt5	175	42	resolve	resolve	VB
cord-016293-pyb00pt5	175	43	a	a	DT
cord-016293-pyb00pt5	175	44	thorny	thorny	JJ
cord-016293-pyb00pt5	175	45	"	"	``
cord-016293-pyb00pt5	175	46	personnel	personnel	NNS
cord-016293-pyb00pt5	175	47	"	"	''
cord-016293-pyb00pt5	175	48	issue	issue	NN
cord-016293-pyb00pt5	175	49	.	.	.
cord-016293-pyb00pt5	176	1	She	-PRON-	PRP
cord-016293-pyb00pt5	176	2	appointed	appoint	VBD
cord-016293-pyb00pt5	176	3	him	-PRON-	PRP
cord-016293-pyb00pt5	176	4	head	head	NN
cord-016293-pyb00pt5	176	5	of	of	IN
cord-016293-pyb00pt5	176	6	the	the	DT
cord-016293-pyb00pt5	176	7	ad	ad	FW
cord-016293-pyb00pt5	176	8	hoc	hoc	FW
cord-016293-pyb00pt5	176	9	committee	committee	NN
cord-016293-pyb00pt5	176	10	to	to	TO
cord-016293-pyb00pt5	176	11	have	have	VB
cord-016293-pyb00pt5	176	12	an	an	DT
cord-016293-pyb00pt5	176	13	intramural	intramural	JJ
cord-016293-pyb00pt5	176	14	genome	genome	NN
cord-016293-pyb00pt5	176	15	program	program	NN
cord-016293-pyb00pt5	176	16	at	at	IN
cord-016293-pyb00pt5	176	17	NIH	NIH	NNP
cord-016293-pyb00pt5	176	18	to	to	TO
cord-016293-pyb00pt5	176	19	give	give	VB
cord-016293-pyb00pt5	176	20	the	the	DT
cord-016293-pyb00pt5	176	21	head	head	NN
cord-016293-pyb00pt5	176	22	of	of	IN
cord-016293-pyb00pt5	176	23	the	the	DT
cord-016293-pyb00pt5	176	24	HGP	HGP	NNP
cord-016293-pyb00pt5	176	25	(	(	-LRB-
cord-016293-pyb00pt5	176	26	that	that	IN
cord-016293-pyb00pt5	176	27	other	other	JJ
cord-016293-pyb00pt5	176	28	larger	large	JJR
cord-016293-pyb00pt5	176	29	than	than	IN
cord-016293-pyb00pt5	176	30	life	life	NN
cord-016293-pyb00pt5	176	31	personality	personality	NN
cord-016293-pyb00pt5	176	32	Jim	Jim	NNP
cord-016293-pyb00pt5	176	33	Watson	Watson	NNP
cord-016293-pyb00pt5	176	34	)	)	-RRB-
cord-016293-pyb00pt5	176	35	notice	notice	VBP
cord-016293-pyb00pt5	176	36	that	that	IN
cord-016293-pyb00pt5	176	37	he	-PRON-	PRP
cord-016293-pyb00pt5	176	38	was	be	VBD
cord-016293-pyb00pt5	176	39	not	not	RB
cord-016293-pyb00pt5	176	40	the	the	DT
cord-016293-pyb00pt5	176	41	sole	sole	JJ
cord-016293-pyb00pt5	176	42	arbitrator	arbitrator	NN
cord-016293-pyb00pt5	176	43	of	of	IN
cord-016293-pyb00pt5	176	44	the	the	DT
cord-016293-pyb00pt5	176	45	direction	direction	NN
cord-016293-pyb00pt5	176	46	for	for	IN
cord-016293-pyb00pt5	176	47	the	the	DT
cord-016293-pyb00pt5	176	48	Human	Human	NNP
cord-016293-pyb00pt5	176	49	Genome	Genome	NNP
cord-016293-pyb00pt5	176	50	Project	Project	NNP
cord-016293-pyb00pt5	176	51	.	.	.
cord-016293-pyb00pt5	177	1	However	however	RB
cord-016293-pyb00pt5	177	2	Venter	Venter	NNP
cord-016293-pyb00pt5	177	3	very	very	RB
cord-016293-pyb00pt5	177	4	soon	soon	RB
cord-016293-pyb00pt5	177	5	established	establish	VBD
cord-016293-pyb00pt5	177	6	himself	-PRON-	PRP
cord-016293-pyb00pt5	177	7	as	as	IN
cord-016293-pyb00pt5	177	8	an	an	DT
cord-016293-pyb00pt5	177	9	equally	equally	RB
cord-016293-pyb00pt5	177	10	non	non	JJ
cord-016293-pyb00pt5	177	11	-	-	JJ
cord-016293-pyb00pt5	177	12	conformist	conformist	JJ
cord-016293-pyb00pt5	177	13	character	character	NN
cord-016293-pyb00pt5	177	14	and	and	CC
cord-016293-pyb00pt5	177	15	with	with	IN
cord-016293-pyb00pt5	177	16	the	the	DT
cord-016293-pyb00pt5	177	17	tacit	tacit	JJ
cord-016293-pyb00pt5	177	18	consent	consent	NN
cord-016293-pyb00pt5	177	19	of	of	IN
cord-016293-pyb00pt5	177	20	his	-PRON-	PRP$
cord-016293-pyb00pt5	177	21	erstwhile	erstwhile	JJ
cord-016293-pyb00pt5	177	22	benefactor	benefactor	NN
cord-016293-pyb00pt5	177	23	.	.	.
cord-016293-pyb00pt5	178	1	He	-PRON-	PRP
cord-016293-pyb00pt5	178	2	initially	initially	RB
cord-016293-pyb00pt5	178	3	assumed	assume	VBD
cord-016293-pyb00pt5	178	4	the	the	DT
cord-016293-pyb00pt5	178	5	mantle	mantle	NN
cord-016293-pyb00pt5	178	6	of	of	IN
cord-016293-pyb00pt5	178	7	a	a	DT
cord-016293-pyb00pt5	178	8	non	non	JJ
cord-016293-pyb00pt5	178	9	-	-	JJ
cord-016293-pyb00pt5	178	10	conformist	conformist	JJ
cord-016293-pyb00pt5	178	11	through	through	IN
cord-016293-pyb00pt5	178	12	guilt	guilt	NN
cord-016293-pyb00pt5	178	13	by	by	IN
cord-016293-pyb00pt5	178	14	association	association	NN
cord-016293-pyb00pt5	178	15	rather	rather	RB
cord-016293-pyb00pt5	178	16	than	than	IN
cord-016293-pyb00pt5	178	17	direct	direct	JJ
cord-016293-pyb00pt5	178	18	actions	action	NNS
cord-016293-pyb00pt5	178	19	when	when	WRB
cord-016293-pyb00pt5	178	20	it	-PRON-	PRP
cord-016293-pyb00pt5	178	21	was	be	VBD
cord-016293-pyb00pt5	178	22	revealed	reveal	VBN
cord-016293-pyb00pt5	178	23	that	that	IN
cord-016293-pyb00pt5	178	24	NIH	NIH	NNP
cord-016293-pyb00pt5	178	25	was	be	VBD
cord-016293-pyb00pt5	178	26	filing	file	VBG
cord-016293-pyb00pt5	178	27	patent	patent	NN
cord-016293-pyb00pt5	178	28	applications	application	NNS
cord-016293-pyb00pt5	178	29	on	on	IN
cord-016293-pyb00pt5	178	30	thousands	thousand	NNS
cord-016293-pyb00pt5	178	31	of	of	IN
cord-016293-pyb00pt5	178	32	these	these	DT
cord-016293-pyb00pt5	178	33	partial	partial	JJ
cord-016293-pyb00pt5	178	34	genes	gene	NNS
cord-016293-pyb00pt5	178	35	based	base	VBN
cord-016293-pyb00pt5	178	36	on	on	IN
cord-016293-pyb00pt5	178	37	his	-PRON-	PRP$
cord-016293-pyb00pt5	178	38	ESTs	est	NNS
cord-016293-pyb00pt5	178	39	catalyzing	catalyze	VBG
cord-016293-pyb00pt5	178	40	the	the	DT
cord-016293-pyb00pt5	178	41	first	first	JJ
cord-016293-pyb00pt5	178	42	HGP	HGP	NNP
cord-016293-pyb00pt5	178	43	fight	fight	NN
cord-016293-pyb00pt5	178	44	at	at	IN
cord-016293-pyb00pt5	178	45	a	a	DT
cord-016293-pyb00pt5	178	46	congressional	congressional	JJ
cord-016293-pyb00pt5	178	47	hearing	hearing	NN
cord-016293-pyb00pt5	178	48	.	.	.
cord-016293-pyb00pt5	179	1	NIH	NIH	NNP
cord-016293-pyb00pt5	179	2	's	's	POS
cord-016293-pyb00pt5	179	3	move	move	NN
cord-016293-pyb00pt5	179	4	was	be	VBD
cord-016293-pyb00pt5	179	5	widely	widely	RB
cord-016293-pyb00pt5	179	6	criticized	criticize	VBN
cord-016293-pyb00pt5	179	7	by	by	IN
cord-016293-pyb00pt5	179	8	the	the	DT
cord-016293-pyb00pt5	179	9	scientific	scientific	JJ
cord-016293-pyb00pt5	179	10	community	community	NN
cord-016293-pyb00pt5	179	11	because	because	IN
cord-016293-pyb00pt5	179	12	,	,	,
cord-016293-pyb00pt5	179	13	at	at	IN
cord-016293-pyb00pt5	179	14	the	the	DT
cord-016293-pyb00pt5	179	15	time	time	NN
cord-016293-pyb00pt5	179	16	,	,	,
cord-016293-pyb00pt5	179	17	the	the	DT
cord-016293-pyb00pt5	179	18	function	function	NN
cord-016293-pyb00pt5	179	19	of	of	IN
cord-016293-pyb00pt5	179	20	genes	gene	NNS
cord-016293-pyb00pt5	179	21	associated	associate	VBN
cord-016293-pyb00pt5	179	22	with	with	IN
cord-016293-pyb00pt5	179	23	the	the	DT
cord-016293-pyb00pt5	179	24	partial	partial	JJ
cord-016293-pyb00pt5	179	25	sequences	sequence	NNS
cord-016293-pyb00pt5	179	26	was	be	VBD
cord-016293-pyb00pt5	179	27	unknown	unknown	JJ
cord-016293-pyb00pt5	179	28	.	.	.
cord-016293-pyb00pt5	180	1	Critics	critic	NNS
cord-016293-pyb00pt5	180	2	charged	charge	VBD
cord-016293-pyb00pt5	180	3	that	that	IN
cord-016293-pyb00pt5	180	4	patent	patent	NN
cord-016293-pyb00pt5	180	5	protection	protection	NN
cord-016293-pyb00pt5	180	6	for	for	IN
cord-016293-pyb00pt5	180	7	the	the	DT
cord-016293-pyb00pt5	180	8	gene	gene	NN
cord-016293-pyb00pt5	180	9	segments	segment	NNS
cord-016293-pyb00pt5	180	10	would	would	MD
cord-016293-pyb00pt5	180	11	forestall	forestall	VB
cord-016293-pyb00pt5	180	12	future	future	JJ
cord-016293-pyb00pt5	180	13	research	research	NN
cord-016293-pyb00pt5	180	14	on	on	IN
cord-016293-pyb00pt5	180	15	them	-PRON-	PRP
cord-016293-pyb00pt5	180	16	.	.	.
cord-016293-pyb00pt5	181	1	The	the	DT
cord-016293-pyb00pt5	181	2	Patent	Patent	NNP
cord-016293-pyb00pt5	181	3	Office	Office	NNP
cord-016293-pyb00pt5	181	4	eventually	eventually	RB
cord-016293-pyb00pt5	181	5	rejected	reject	VBD
cord-016293-pyb00pt5	181	6	the	the	DT
cord-016293-pyb00pt5	181	7	patents	patent	NNS
cord-016293-pyb00pt5	181	8	,	,	,
cord-016293-pyb00pt5	181	9	but	but	CC
cord-016293-pyb00pt5	181	10	the	the	DT
cord-016293-pyb00pt5	181	11	applications	application	NNS
cord-016293-pyb00pt5	181	12	sparked	spark	VBD
cord-016293-pyb00pt5	181	13	an	an	DT
cord-016293-pyb00pt5	181	14	international	international	JJ
cord-016293-pyb00pt5	181	15	controversy	controversy	NN
cord-016293-pyb00pt5	181	16	over	over	IN
cord-016293-pyb00pt5	181	17	patenting	patent	VBG
cord-016293-pyb00pt5	181	18	genes	gene	NNS
cord-016293-pyb00pt5	181	19	whose	whose	WP$
cord-016293-pyb00pt5	181	20	functions	function	NNS
cord-016293-pyb00pt5	181	21	were	be	VBD
cord-016293-pyb00pt5	181	22	still	still	RB
cord-016293-pyb00pt5	181	23	unknown	unknown	JJ
cord-016293-pyb00pt5	181	24	.	.	.
cord-016293-pyb00pt5	182	1	Interestingly	interestingly	RB
cord-016293-pyb00pt5	182	2	enough	enough	RB
cord-016293-pyb00pt5	182	3	despite	despite	IN
cord-016293-pyb00pt5	182	4	NIH	NIH	NNP
cord-016293-pyb00pt5	182	5	's	's	POS
cord-016293-pyb00pt5	182	6	reliance	reliance	NN
cord-016293-pyb00pt5	182	7	on	on	IN
cord-016293-pyb00pt5	182	8	the	the	DT
cord-016293-pyb00pt5	182	9	EST	EST	NNP
cord-016293-pyb00pt5	182	10	/	/	SYM
cord-016293-pyb00pt5	182	11	cDNA	cdna	NN
cord-016293-pyb00pt5	182	12	technique	technique	NN
cord-016293-pyb00pt5	182	13	,	,	,
cord-016293-pyb00pt5	182	14	Venter	Venter	NNP
cord-016293-pyb00pt5	182	15	,	,	,
cord-016293-pyb00pt5	182	16	who	who	WP
cord-016293-pyb00pt5	182	17	was	be	VBD
cord-016293-pyb00pt5	182	18	now	now	RB
cord-016293-pyb00pt5	182	19	clearly	clearly	RB
cord-016293-pyb00pt5	182	20	venturing	venture	VBG
cord-016293-pyb00pt5	182	21	outside	outside	IN
cord-016293-pyb00pt5	182	22	the	the	DT
cord-016293-pyb00pt5	182	23	NINDS	NINDS	NNP
cord-016293-pyb00pt5	182	24	mandated	mandate	VBN
cord-016293-pyb00pt5	182	25	rubric	rubric	NN
cord-016293-pyb00pt5	182	26	,	,	,
cord-016293-pyb00pt5	182	27	could	could	MD
cord-016293-pyb00pt5	182	28	not	not	RB
cord-016293-pyb00pt5	182	29	obtain	obtain	VB
cord-016293-pyb00pt5	182	30	government	government	NN
cord-016293-pyb00pt5	182	31	funding	funding	NN
cord-016293-pyb00pt5	182	32	to	to	TO
cord-016293-pyb00pt5	182	33	expand	expand	VB
cord-016293-pyb00pt5	182	34	his	-PRON-	PRP$
cord-016293-pyb00pt5	182	35	research	research	NN
cord-016293-pyb00pt5	182	36	,	,	,
cord-016293-pyb00pt5	182	37	prompting	prompt	VBG
cord-016293-pyb00pt5	182	38	him	-PRON-	PRP
cord-016293-pyb00pt5	182	39	to	to	TO
cord-016293-pyb00pt5	182	40	leave	leave	VB
cord-016293-pyb00pt5	182	41	NIH	NIH	NNP
cord-016293-pyb00pt5	182	42	in	in	IN
cord-016293-pyb00pt5	182	43	1992	1992	CD
cord-016293-pyb00pt5	182	44	.	.	.
cord-016293-pyb00pt5	183	1	He	-PRON-	PRP
cord-016293-pyb00pt5	183	2	moved	move	VBD
cord-016293-pyb00pt5	183	3	on	on	RP
cord-016293-pyb00pt5	183	4	to	to	TO
cord-016293-pyb00pt5	183	5	become	become	VB
cord-016293-pyb00pt5	183	6	president	president	NN
cord-016293-pyb00pt5	183	7	and	and	CC
cord-016293-pyb00pt5	183	8	director	director	NN
cord-016293-pyb00pt5	183	9	of	of	IN
cord-016293-pyb00pt5	183	10	The	the	DT
cord-016293-pyb00pt5	183	11	Institute	Institute	NNP
cord-016293-pyb00pt5	183	12	for	for	IN
cord-016293-pyb00pt5	183	13	Genomic	Genomic	NNP
cord-016293-pyb00pt5	183	14	Research	Research	NNP
cord-016293-pyb00pt5	183	15	(	(	-LRB-
cord-016293-pyb00pt5	183	16	TIGR	TIGR	NNP
cord-016293-pyb00pt5	183	17	)	)	-RRB-
cord-016293-pyb00pt5	183	18	,	,	,
cord-016293-pyb00pt5	183	19	a	a	DT
cord-016293-pyb00pt5	183	20	nonprofit	nonprofit	JJ
cord-016293-pyb00pt5	183	21	research	research	NN
cord-016293-pyb00pt5	183	22	center	center	NN
cord-016293-pyb00pt5	183	23	based	base	VBN
cord-016293-pyb00pt5	183	24	in	in	IN
cord-016293-pyb00pt5	183	25	Gaithersburg	Gaithersburg	NNP
cord-016293-pyb00pt5	183	26	,	,	,
cord-016293-pyb00pt5	184	1	Md.	Md.	NNP
cord-016293-pyb00pt5	184	2	At	at	IN
cord-016293-pyb00pt5	184	3	the	the	DT
cord-016293-pyb00pt5	184	4	same	same	JJ
cord-016293-pyb00pt5	184	5	time	time	NN
cord-016293-pyb00pt5	184	6	William	William	NNP
cord-016293-pyb00pt5	184	7	Haseltine	Haseltine	NNP
cord-016293-pyb00pt5	184	8	formed	form	VBD
cord-016293-pyb00pt5	184	9	a	a	DT
cord-016293-pyb00pt5	184	10	sister	sister	NN
cord-016293-pyb00pt5	184	11	company	company	NN
cord-016293-pyb00pt5	184	12	,	,	,
cord-016293-pyb00pt5	184	13	Human	Human	NNP
cord-016293-pyb00pt5	184	14	Genome	Genome	NNP
cord-016293-pyb00pt5	184	15	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	184	16	(	(	-LRB-
cord-016293-pyb00pt5	184	17	HGS	HGS	NNP
cord-016293-pyb00pt5	184	18	)	)	-RRB-
cord-016293-pyb00pt5	184	19	,	,	,
cord-016293-pyb00pt5	184	20	to	to	TO
cord-016293-pyb00pt5	184	21	commercialize	commercialize	VB
cord-016293-pyb00pt5	184	22	TIGR	TIGR	NNP
cord-016293-pyb00pt5	184	23	products	product	NNS
cord-016293-pyb00pt5	184	24	.	.	.
cord-016293-pyb00pt5	185	1	Venter	Venter	NNP
cord-016293-pyb00pt5	185	2	continued	continue	VBD
cord-016293-pyb00pt5	185	3	EST	est	NN
cord-016293-pyb00pt5	185	4	work	work	NN
cord-016293-pyb00pt5	185	5	at	at	IN
cord-016293-pyb00pt5	185	6	TIGR	TIGR	NNP
cord-016293-pyb00pt5	185	7	,	,	,
cord-016293-pyb00pt5	185	8	but	but	CC
cord-016293-pyb00pt5	185	9	also	also	RB
cord-016293-pyb00pt5	185	10	began	begin	VBD
cord-016293-pyb00pt5	185	11	thinking	think	VBG
cord-016293-pyb00pt5	185	12	about	about	IN
cord-016293-pyb00pt5	185	13	sequencing	sequence	VBG
cord-016293-pyb00pt5	185	14	entire	entire	JJ
cord-016293-pyb00pt5	185	15	genomes	genome	NNS
cord-016293-pyb00pt5	185	16	.	.	.
cord-016293-pyb00pt5	186	1	Again	again	RB
cord-016293-pyb00pt5	186	2	,	,	,
cord-016293-pyb00pt5	186	3	he	-PRON-	PRP
cord-016293-pyb00pt5	186	4	came	come	VBD
cord-016293-pyb00pt5	186	5	up	up	RP
cord-016293-pyb00pt5	186	6	with	with	IN
cord-016293-pyb00pt5	186	7	a	a	DT
cord-016293-pyb00pt5	186	8	quicker	quick	JJR
cord-016293-pyb00pt5	186	9	and	and	CC
cord-016293-pyb00pt5	186	10	faster	fast	JJR
cord-016293-pyb00pt5	186	11	method	method	NN
cord-016293-pyb00pt5	186	12	:	:	:
cord-016293-pyb00pt5	186	13	whole	whole	JJ
cord-016293-pyb00pt5	186	14	genome	genome	NN
cord-016293-pyb00pt5	186	15	shotgun	shotgun	NN
cord-016293-pyb00pt5	186	16	sequencing	sequencing	NN
cord-016293-pyb00pt5	186	17	.	.	.
cord-016293-pyb00pt5	187	1	He	-PRON-	PRP
cord-016293-pyb00pt5	187	2	applied	apply	VBD
cord-016293-pyb00pt5	187	3	for	for	IN
cord-016293-pyb00pt5	187	4	an	an	DT
cord-016293-pyb00pt5	187	5	NIH	NIH	NNP
cord-016293-pyb00pt5	187	6	grant	grant	NN
cord-016293-pyb00pt5	187	7	to	to	TO
cord-016293-pyb00pt5	187	8	use	use	VB
cord-016293-pyb00pt5	187	9	the	the	DT
cord-016293-pyb00pt5	187	10	method	method	NN
cord-016293-pyb00pt5	187	11	on	on	IN
cord-016293-pyb00pt5	187	12	Hemophilus	Hemophilus	NNP
cord-016293-pyb00pt5	187	13	influenzae	influenzae	NN
cord-016293-pyb00pt5	187	14	,	,	,
cord-016293-pyb00pt5	187	15	but	but	CC
cord-016293-pyb00pt5	187	16	started	start	VBD
cord-016293-pyb00pt5	187	17	the	the	DT
cord-016293-pyb00pt5	187	18	project	project	NN
cord-016293-pyb00pt5	187	19	before	before	IN
cord-016293-pyb00pt5	187	20	the	the	DT
cord-016293-pyb00pt5	187	21	funding	funding	NN
cord-016293-pyb00pt5	187	22	decision	decision	NN
cord-016293-pyb00pt5	187	23	was	be	VBD
cord-016293-pyb00pt5	187	24	returned	return	VBN
cord-016293-pyb00pt5	187	25	.	.	.
cord-016293-pyb00pt5	188	1	When	when	WRB
cord-016293-pyb00pt5	188	2	the	the	DT
cord-016293-pyb00pt5	188	3	genome	genome	NN
cord-016293-pyb00pt5	188	4	was	be	VBD
cord-016293-pyb00pt5	188	5	nearly	nearly	RB
cord-016293-pyb00pt5	188	6	complete	complete	JJ
cord-016293-pyb00pt5	188	7	,	,	,
cord-016293-pyb00pt5	188	8	NIH	NIH	NNP
cord-016293-pyb00pt5	188	9	rejected	reject	VBD
cord-016293-pyb00pt5	188	10	his	-PRON-	PRP$
cord-016293-pyb00pt5	188	11	proposal	proposal	NN
cord-016293-pyb00pt5	188	12	saying	say	VBG
cord-016293-pyb00pt5	188	13	the	the	DT
cord-016293-pyb00pt5	188	14	method	method	NN
cord-016293-pyb00pt5	188	15	would	would	MD
cord-016293-pyb00pt5	188	16	not	not	RB
cord-016293-pyb00pt5	188	17	work	work	VB
cord-016293-pyb00pt5	188	18	.	.	.
cord-016293-pyb00pt5	189	1	In	in	IN
cord-016293-pyb00pt5	189	2	a	a	DT
cord-016293-pyb00pt5	189	3	triumphal	triumphal	JJ
cord-016293-pyb00pt5	189	4	flurry	flurry	NN
cord-016293-pyb00pt5	189	5	in	in	IN
cord-016293-pyb00pt5	189	6	late	late	JJ
cord-016293-pyb00pt5	189	7	May	May	NNP
cord-016293-pyb00pt5	189	8	1995	1995	CD
cord-016293-pyb00pt5	189	9	and	and	CC
cord-016293-pyb00pt5	189	10	with	with	IN
cord-016293-pyb00pt5	189	11	a	a	DT
cord-016293-pyb00pt5	189	12	metaphorical	metaphorical	JJ
cord-016293-pyb00pt5	189	13	nose	nose	NN
cord-016293-pyb00pt5	189	14	-	-	HYPH
cord-016293-pyb00pt5	189	15	thumbing	thumbing	NN
cord-016293-pyb00pt5	189	16	at	at	IN
cord-016293-pyb00pt5	189	17	his	-PRON-	PRP$
cord-016293-pyb00pt5	189	18	recently	recently	RB
cord-016293-pyb00pt5	189	19	rejected	reject	VBN
cord-016293-pyb00pt5	189	20	"	"	``
cord-016293-pyb00pt5	189	21	unworkable	unworkable	JJ
cord-016293-pyb00pt5	189	22	"	"	''
cord-016293-pyb00pt5	189	23	grant	grant	NN
cord-016293-pyb00pt5	190	1	Venter	Venter	NNP
cord-016293-pyb00pt5	190	2	announced	announce	VBD
cord-016293-pyb00pt5	190	3	that	that	IN
cord-016293-pyb00pt5	190	4	TIGR	TIGR	NNP
cord-016293-pyb00pt5	190	5	and	and	CC
cord-016293-pyb00pt5	190	6	collaborators	collaborator	NNS
cord-016293-pyb00pt5	190	7	had	have	VBD
cord-016293-pyb00pt5	190	8	fully	fully	RB
cord-016293-pyb00pt5	190	9	sequenced	sequence	VBN
cord-016293-pyb00pt5	190	10	the	the	DT
cord-016293-pyb00pt5	190	11	first	first	JJ
cord-016293-pyb00pt5	190	12	free	free	JJ
cord-016293-pyb00pt5	190	13	-	-	HYPH
cord-016293-pyb00pt5	190	14	living	live	VBG
cord-016293-pyb00pt5	190	15	organism	organism	NN
cord-016293-pyb00pt5	190	16	-Haemophilus	-Haemophilus	.
cord-016293-pyb00pt5	190	17	influenzae	influenzae	NN
cord-016293-pyb00pt5	190	18	.	.	.
cord-016293-pyb00pt5	191	1	In	in	IN
cord-016293-pyb00pt5	191	2	November	November	NNP
cord-016293-pyb00pt5	191	3	1994	1994	CD
cord-016293-pyb00pt5	191	4	,	,	,
cord-016293-pyb00pt5	191	5	controversy	controversy	NN
cord-016293-pyb00pt5	191	6	surrounding	surround	VBG
cord-016293-pyb00pt5	191	7	Venter	Venter	NNP
cord-016293-pyb00pt5	191	8	's	's	POS
cord-016293-pyb00pt5	191	9	research	research	NN
cord-016293-pyb00pt5	191	10	escalated	escalate	VBD
cord-016293-pyb00pt5	191	11	.	.	.
cord-016293-pyb00pt5	192	1	Access	access	NN
cord-016293-pyb00pt5	192	2	restrictions	restriction	NNS
cord-016293-pyb00pt5	192	3	associated	associate	VBN
cord-016293-pyb00pt5	192	4	with	with	IN
cord-016293-pyb00pt5	192	5	a	a	DT
cord-016293-pyb00pt5	192	6	cDNA	cdna	NN
cord-016293-pyb00pt5	192	7	database	database	NN
cord-016293-pyb00pt5	192	8	developed	develop	VBN
cord-016293-pyb00pt5	192	9	by	by	IN
cord-016293-pyb00pt5	192	10	TIGR	TIGR	NNP
cord-016293-pyb00pt5	192	11	and	and	CC
cord-016293-pyb00pt5	193	1	its	-PRON-	PRP$
cord-016293-pyb00pt5	193	2	Rockville	Rockville	NNP
cord-016293-pyb00pt5	193	3	,	,	,
cord-016293-pyb00pt5	193	4	Md.-based	md.-based	JJ
cord-016293-pyb00pt5	193	5	biotech	biotech	NN
cord-016293-pyb00pt5	193	6	associate	associate	NN
cord-016293-pyb00pt5	193	7	,	,	,
cord-016293-pyb00pt5	193	8	Human	Human	NNP
cord-016293-pyb00pt5	193	9	Genome	Genome	NNP
cord-016293-pyb00pt5	193	10	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	193	11	(	(	-LRB-
cord-016293-pyb00pt5	193	12	HGS	HGS	NNP
cord-016293-pyb00pt5	193	13	)	)	-RRB-
cord-016293-pyb00pt5	193	14	Inc.	Inc.	NNP
cord-016293-pyb00pt5	194	1	-including	-include	VBG
cord-016293-pyb00pt5	195	1	HGS	HGS	NNP
cord-016293-pyb00pt5	195	2	's	's	POS
cord-016293-pyb00pt5	195	3	right	right	NN
cord-016293-pyb00pt5	195	4	to	to	TO
cord-016293-pyb00pt5	195	5	preview	preview	VB
cord-016293-pyb00pt5	195	6	papers	paper	NNS
cord-016293-pyb00pt5	195	7	on	on	IN
cord-016293-pyb00pt5	195	8	resulting	result	VBG
cord-016293-pyb00pt5	195	9	discoveries	discovery	NNS
cord-016293-pyb00pt5	195	10	and	and	CC
cord-016293-pyb00pt5	195	11	for	for	IN
cord-016293-pyb00pt5	195	12	first	first	JJ
cord-016293-pyb00pt5	195	13	options	option	NNS
cord-016293-pyb00pt5	195	14	to	to	TO
cord-016293-pyb00pt5	195	15	license	license	VB
cord-016293-pyb00pt5	195	16	products	product	NNS
cord-016293-pyb00pt5	195	17	-prompted	-prompte	VBD
cord-016293-pyb00pt5	195	18	Merck	Merck	NNP
cord-016293-pyb00pt5	195	19	and	and	CC
cord-016293-pyb00pt5	195	20	Co.	Co.	NNP
cord-016293-pyb00pt5	195	21	Inc.	Inc.	NNP
cord-016293-pyb00pt5	195	22	to	to	TO
cord-016293-pyb00pt5	195	23	fund	fund	VB
cord-016293-pyb00pt5	195	24	a	a	DT
cord-016293-pyb00pt5	195	25	rival	rival	JJ
cord-016293-pyb00pt5	195	26	database	database	NN
cord-016293-pyb00pt5	195	27	project	project	NN
cord-016293-pyb00pt5	195	28	.	.	.
cord-016293-pyb00pt5	196	1	In	in	IN
cord-016293-pyb00pt5	196	2	that	that	DT
cord-016293-pyb00pt5	196	3	year	year	NN
cord-016293-pyb00pt5	196	4	also	also	RB
cord-016293-pyb00pt5	196	5	Britain	Britain	NNP
cord-016293-pyb00pt5	196	6	"	"	``
cord-016293-pyb00pt5	196	7	officially	officially	RB
cord-016293-pyb00pt5	196	8	"	"	''
cord-016293-pyb00pt5	196	9	entered	enter	VBD
cord-016293-pyb00pt5	196	10	the	the	DT
cord-016293-pyb00pt5	196	11	HGP	hgp	NN
cord-016293-pyb00pt5	196	12	race	race	NN
cord-016293-pyb00pt5	196	13	when	when	WRB
cord-016293-pyb00pt5	196	14	the	the	DT
cord-016293-pyb00pt5	196	15	Wellcome	Wellcome	NNP
cord-016293-pyb00pt5	196	16	Trust	Trust	NNP
cord-016293-pyb00pt5	196	17	trumped	trump	VBD
cord-016293-pyb00pt5	196	18	down	down	RP
cord-016293-pyb00pt5	196	19	$	$	$
cord-016293-pyb00pt5	196	20	95	95	CD
cord-016293-pyb00pt5	196	21	million	million	CD
cord-016293-pyb00pt5	196	22	(	(	-LRB-
cord-016293-pyb00pt5	196	23	as	as	IN
cord-016293-pyb00pt5	196	24	mentioned	mention	VBN
cord-016293-pyb00pt5	196	25	earlier	early	RBR
cord-016293-pyb00pt5	196	26	)	)	-RRB-
cord-016293-pyb00pt5	196	27	.	.	.
cord-016293-pyb00pt5	197	1	The	the	DT
cord-016293-pyb00pt5	197	2	following	following	JJ
cord-016293-pyb00pt5	197	3	year	year	NN
cord-016293-pyb00pt5	197	4	HGS	HGS	NNP
cord-016293-pyb00pt5	197	5	was	be	VBD
cord-016293-pyb00pt5	197	6	involved	involve	VBN
cord-016293-pyb00pt5	197	7	in	in	IN
cord-016293-pyb00pt5	197	8	yet	yet	RB
cord-016293-pyb00pt5	197	9	another	another	DT
cord-016293-pyb00pt5	197	10	patenting	patenting	NN
cord-016293-pyb00pt5	197	11	debacle	debacle	NN
cord-016293-pyb00pt5	197	12	forced	force	VBN
cord-016293-pyb00pt5	197	13	by	by	IN
cord-016293-pyb00pt5	197	14	the	the	DT
cord-016293-pyb00pt5	197	15	rapid	rapid	JJ
cord-016293-pyb00pt5	197	16	march	march	NN
cord-016293-pyb00pt5	197	17	of	of	IN
cord-016293-pyb00pt5	197	18	technology	technology	NN
cord-016293-pyb00pt5	197	19	into	into	IN
cord-016293-pyb00pt5	197	20	uncharted	uncharted	JJ
cord-016293-pyb00pt5	197	21	patent	patent	NN
cord-016293-pyb00pt5	197	22	law	law	NN
cord-016293-pyb00pt5	197	23	territory	territory	NN
cord-016293-pyb00pt5	197	24	.	.	.
cord-016293-pyb00pt5	198	1	On	on	IN
cord-016293-pyb00pt5	198	2	June	June	NNP
cord-016293-pyb00pt5	198	3	5	5	CD
cord-016293-pyb00pt5	198	4	,	,	,
cord-016293-pyb00pt5	198	5	1995	1995	CD
cord-016293-pyb00pt5	198	6	HGS	hgs	NN
cord-016293-pyb00pt5	198	7	applied	apply	VBD
cord-016293-pyb00pt5	198	8	for	for	IN
cord-016293-pyb00pt5	198	9	a	a	DT
cord-016293-pyb00pt5	198	10	patent	patent	NN
cord-016293-pyb00pt5	198	11	on	on	IN
cord-016293-pyb00pt5	198	12	a	a	DT
cord-016293-pyb00pt5	198	13	gene	gene	NN
cord-016293-pyb00pt5	198	14	that	that	WDT
cord-016293-pyb00pt5	198	15	produces	produce	VBZ
cord-016293-pyb00pt5	198	16	a	a	DT
cord-016293-pyb00pt5	198	17	"	"	``
cord-016293-pyb00pt5	198	18	receptor	receptor	NN
cord-016293-pyb00pt5	198	19	"	"	''
cord-016293-pyb00pt5	198	20	protein	protein	NN
cord-016293-pyb00pt5	198	21	that	that	WDT
cord-016293-pyb00pt5	198	22	is	be	VBZ
cord-016293-pyb00pt5	198	23	later	later	RB
cord-016293-pyb00pt5	198	24	called	call	VBN
cord-016293-pyb00pt5	198	25	CCR5	CCR5	NNP
cord-016293-pyb00pt5	198	26	.	.	.
cord-016293-pyb00pt5	199	1	At	at	IN
cord-016293-pyb00pt5	199	2	that	that	DT
cord-016293-pyb00pt5	199	3	time	time	NN
cord-016293-pyb00pt5	199	4	HGS	HGS	NNP
cord-016293-pyb00pt5	199	5	has	have	VBZ
cord-016293-pyb00pt5	199	6	no	no	DT
cord-016293-pyb00pt5	199	7	idea	idea	NN
cord-016293-pyb00pt5	199	8	that	that	IN
cord-016293-pyb00pt5	199	9	CCR5	CCR5	NNP
cord-016293-pyb00pt5	199	10	is	be	VBZ
cord-016293-pyb00pt5	199	11	an	an	DT
cord-016293-pyb00pt5	199	12	HIV	HIV	NNP
cord-016293-pyb00pt5	199	13	receptor	receptor	NN
cord-016293-pyb00pt5	199	14	.	.	.
cord-016293-pyb00pt5	200	1	In	in	IN
cord-016293-pyb00pt5	200	2	December	December	NNP
cord-016293-pyb00pt5	200	3	1995	1995	CD
cord-016293-pyb00pt5	200	4	,	,	,
cord-016293-pyb00pt5	200	5	U.S.	U.S.	NNP
cord-016293-pyb00pt5	200	6	researcher	researcher	NN
cord-016293-pyb00pt5	200	7	Robert	Robert	NNP
cord-016293-pyb00pt5	200	8	Gallo	Gallo	NNP
cord-016293-pyb00pt5	200	9	,	,	,
cord-016293-pyb00pt5	200	10	the	the	DT
cord-016293-pyb00pt5	200	11	co	co	NN
cord-016293-pyb00pt5	200	12	-	-	NN
cord-016293-pyb00pt5	200	13	discoverer	discoverer	NN
cord-016293-pyb00pt5	200	14	of	of	IN
cord-016293-pyb00pt5	200	15	HIV	HIV	NNP
cord-016293-pyb00pt5	200	16	,	,	,
cord-016293-pyb00pt5	200	17	and	and	CC
cord-016293-pyb00pt5	200	18	colleagues	colleague	NNS
cord-016293-pyb00pt5	200	19	found	find	VBD
cord-016293-pyb00pt5	200	20	three	three	CD
cord-016293-pyb00pt5	200	21	chemicals	chemical	NNS
cord-016293-pyb00pt5	200	22	that	that	WDT
cord-016293-pyb00pt5	200	23	inhibit	inhibit	VBP
cord-016293-pyb00pt5	200	24	the	the	DT
cord-016293-pyb00pt5	200	25	AIDS	AIDS	NNP
cord-016293-pyb00pt5	200	26	virus	virus	NN
cord-016293-pyb00pt5	201	1	but	but	CC
cord-016293-pyb00pt5	201	2	they	-PRON-	PRP
cord-016293-pyb00pt5	201	3	did	do	VBD
cord-016293-pyb00pt5	201	4	not	not	RB
cord-016293-pyb00pt5	201	5	know	know	VB
cord-016293-pyb00pt5	201	6	how	how	WRB
cord-016293-pyb00pt5	201	7	the	the	DT
cord-016293-pyb00pt5	201	8	chemicals	chemical	NNS
cord-016293-pyb00pt5	201	9	work	work	VBP
cord-016293-pyb00pt5	201	10	.	.	.
cord-016293-pyb00pt5	202	1	In	in	IN
cord-016293-pyb00pt5	202	2	February	February	NNP
cord-016293-pyb00pt5	202	3	1996	1996	CD
cord-016293-pyb00pt5	202	4	,	,	,
cord-016293-pyb00pt5	202	5	Edward	Edward	NNP
cord-016293-pyb00pt5	202	6	Berger	Berger	NNP
cord-016293-pyb00pt5	202	7	at	at	IN
cord-016293-pyb00pt5	202	8	the	the	DT
cord-016293-pyb00pt5	202	9	NIH	NIH	NNP
cord-016293-pyb00pt5	202	10	discovered	discover	VBD
cord-016293-pyb00pt5	202	11	that	that	IN
cord-016293-pyb00pt5	202	12	Gallo	Gallo	NNP
cord-016293-pyb00pt5	202	13	's	's	POS
cord-016293-pyb00pt5	202	14	inhibitors	inhibitor	NNS
cord-016293-pyb00pt5	202	15	work	work	VBP
cord-016293-pyb00pt5	202	16	in	in	IN
cord-016293-pyb00pt5	202	17	late	late	JJ
cord-016293-pyb00pt5	202	18	-	-	HYPH
cord-016293-pyb00pt5	202	19	stage	stage	NN
cord-016293-pyb00pt5	202	20	AIDS	AIDS	NNP
cord-016293-pyb00pt5	202	21	by	by	IN
cord-016293-pyb00pt5	202	22	blocking	block	VBG
cord-016293-pyb00pt5	202	23	a	a	DT
cord-016293-pyb00pt5	202	24	receptor	receptor	NN
cord-016293-pyb00pt5	202	25	on	on	IN
cord-016293-pyb00pt5	202	26	the	the	DT
cord-016293-pyb00pt5	202	27	surface	surface	NN
cord-016293-pyb00pt5	202	28	of	of	IN
cord-016293-pyb00pt5	202	29	T	t	NN
cord-016293-pyb00pt5	202	30	-	-	HYPH
cord-016293-pyb00pt5	202	31	cells	cell	NNS
cord-016293-pyb00pt5	202	32	.	.	.
cord-016293-pyb00pt5	203	1	In	in	IN
cord-016293-pyb00pt5	203	2	June	June	NNP
cord-016293-pyb00pt5	203	3	of	of	IN
cord-016293-pyb00pt5	203	4	that	that	DT
cord-016293-pyb00pt5	203	5	year	year	NN
cord-016293-pyb00pt5	203	6	in	in	IN
cord-016293-pyb00pt5	203	7	a	a	DT
cord-016293-pyb00pt5	203	8	period	period	NN
cord-016293-pyb00pt5	203	9	of	of	IN
cord-016293-pyb00pt5	203	10	just	just	RB
cord-016293-pyb00pt5	203	11	10	10	CD
cord-016293-pyb00pt5	203	12	days	day	NNS
cord-016293-pyb00pt5	203	13	,	,	,
cord-016293-pyb00pt5	203	14	five	five	CD
cord-016293-pyb00pt5	203	15	groups	group	NNS
cord-016293-pyb00pt5	203	16	of	of	IN
cord-016293-pyb00pt5	203	17	scientists	scientist	NNS
cord-016293-pyb00pt5	203	18	published	publish	VBD
cord-016293-pyb00pt5	203	19	papers	paper	NNS
cord-016293-pyb00pt5	203	20	saying	say	VBG
cord-016293-pyb00pt5	203	21	CCR5	CCR5	NNP
cord-016293-pyb00pt5	203	22	is	be	VBZ
cord-016293-pyb00pt5	203	23	the	the	DT
cord-016293-pyb00pt5	203	24	receptor	receptor	NN
cord-016293-pyb00pt5	203	25	for	for	IN
cord-016293-pyb00pt5	203	26	virtually	virtually	RB
cord-016293-pyb00pt5	203	27	all	all	DT
cord-016293-pyb00pt5	203	28	strains	strain	NNS
cord-016293-pyb00pt5	203	29	of	of	IN
cord-016293-pyb00pt5	203	30	HIV	HIV	NNP
cord-016293-pyb00pt5	203	31	.	.	.
cord-016293-pyb00pt5	204	1	In	in	IN
cord-016293-pyb00pt5	204	2	January	January	NNP
cord-016293-pyb00pt5	204	3	2000	2000	CD
cord-016293-pyb00pt5	204	4	,	,	,
cord-016293-pyb00pt5	204	5	Schering	Schering	NNP
cord-016293-pyb00pt5	204	6	-	-	HYPH
cord-016293-pyb00pt5	204	7	Plough	Plough	NNP
cord-016293-pyb00pt5	204	8	researchers	researcher	NNS
cord-016293-pyb00pt5	204	9	told	tell	VBD
cord-016293-pyb00pt5	204	10	a	a	DT
cord-016293-pyb00pt5	204	11	San	San	NNP
cord-016293-pyb00pt5	204	12	Francisco	Francisco	NNP
cord-016293-pyb00pt5	204	13	AIDS	AIDS	NNP
cord-016293-pyb00pt5	204	14	conference	conference	NN
cord-016293-pyb00pt5	204	15	that	that	IN
cord-016293-pyb00pt5	204	16	they	-PRON-	PRP
cord-016293-pyb00pt5	204	17	have	have	VBP
cord-016293-pyb00pt5	204	18	discovered	discover	VBN
cord-016293-pyb00pt5	204	19	new	new	JJ
cord-016293-pyb00pt5	204	20	inhibitors	inhibitor	NNS
cord-016293-pyb00pt5	204	21	.	.	.
cord-016293-pyb00pt5	205	1	They	-PRON-	PRP
cord-016293-pyb00pt5	205	2	knew	know	VBD
cord-016293-pyb00pt5	205	3	that	that	IN
cord-016293-pyb00pt5	205	4	Merck	Merck	NNP
cord-016293-pyb00pt5	205	5	researchers	researcher	NNS
cord-016293-pyb00pt5	205	6	had	have	VBD
cord-016293-pyb00pt5	205	7	made	make	VBN
cord-016293-pyb00pt5	205	8	similar	similar	JJ
cord-016293-pyb00pt5	205	9	discoveries	discovery	NNS
cord-016293-pyb00pt5	205	10	.	.	.
cord-016293-pyb00pt5	206	1	As	as	IN
cord-016293-pyb00pt5	206	2	a	a	DT
cord-016293-pyb00pt5	206	3	significant	significant	JJ
cord-016293-pyb00pt5	206	4	Valentine	Valentine	NNP
cord-016293-pyb00pt5	206	5	in	in	IN
cord-016293-pyb00pt5	206	6	2000	2000	CD
cord-016293-pyb00pt5	206	7	the	the	DT
cord-016293-pyb00pt5	206	8	U.S.	U.S.	NNP
cord-016293-pyb00pt5	206	9	Patent	Patent	NNP
cord-016293-pyb00pt5	206	10	and	and	CC
cord-016293-pyb00pt5	206	11	Trademark	Trademark	NNP
cord-016293-pyb00pt5	206	12	Office	Office	NNP
cord-016293-pyb00pt5	206	13	(	(	-LRB-
cord-016293-pyb00pt5	206	14	USPTO	USPTO	NNP
cord-016293-pyb00pt5	206	15	)	)	-RRB-
cord-016293-pyb00pt5	206	16	grants	grant	VBZ
cord-016293-pyb00pt5	206	17	HGS	HGS	NNP
cord-016293-pyb00pt5	206	18	a	a	DT
cord-016293-pyb00pt5	206	19	patent	patent	NN
cord-016293-pyb00pt5	206	20	on	on	IN
cord-016293-pyb00pt5	206	21	the	the	DT
cord-016293-pyb00pt5	206	22	gene	gene	NN
cord-016293-pyb00pt5	206	23	that	that	WDT
cord-016293-pyb00pt5	206	24	makes	make	VBZ
cord-016293-pyb00pt5	206	25	CCR5	CCR5	NNP
cord-016293-pyb00pt5	206	26	and	and	CC
cord-016293-pyb00pt5	206	27	on	on	IN
cord-016293-pyb00pt5	206	28	techniques	technique	NNS
cord-016293-pyb00pt5	206	29	for	for	IN
cord-016293-pyb00pt5	206	30	producing	produce	VBG
cord-016293-pyb00pt5	206	31	CCR5	CCR5	NNP
cord-016293-pyb00pt5	206	32	artificially	artificially	RB
cord-016293-pyb00pt5	206	33	.	.	.
cord-016293-pyb00pt5	207	1	The	the	DT
cord-016293-pyb00pt5	207	2	decision	decision	NN
cord-016293-pyb00pt5	207	3	sent	send	VBD
cord-016293-pyb00pt5	207	4	HGS	HGS	NNP
cord-016293-pyb00pt5	207	5	stock	stock	NN
cord-016293-pyb00pt5	207	6	flying	fly	VBG
cord-016293-pyb00pt5	207	7	and	and	CC
cord-016293-pyb00pt5	207	8	dismayed	dismayed	JJ
cord-016293-pyb00pt5	207	9	researchers	researcher	NNS
cord-016293-pyb00pt5	207	10	.	.	.
cord-016293-pyb00pt5	208	1	It	-PRON-	PRP
cord-016293-pyb00pt5	208	2	also	also	RB
cord-016293-pyb00pt5	208	3	caused	cause	VBD
cord-016293-pyb00pt5	208	4	the	the	DT
cord-016293-pyb00pt5	208	5	USPTO	USPTO	NNP
cord-016293-pyb00pt5	208	6	to	to	TO
cord-016293-pyb00pt5	208	7	revise	revise	VB
cord-016293-pyb00pt5	208	8	its	-PRON-	PRP$
cord-016293-pyb00pt5	208	9	definition	definition	NN
cord-016293-pyb00pt5	208	10	of	of	IN
cord-016293-pyb00pt5	208	11	a	a	DT
cord-016293-pyb00pt5	208	12	"	"	``
cord-016293-pyb00pt5	208	13	patentable	patentable	JJ
cord-016293-pyb00pt5	208	14	"	"	''
cord-016293-pyb00pt5	208	15	drug	drug	NN
cord-016293-pyb00pt5	208	16	target	target	NN
cord-016293-pyb00pt5	208	17	.	.	.
cord-016293-pyb00pt5	209	1	In	in	IN
cord-016293-pyb00pt5	209	2	the	the	DT
cord-016293-pyb00pt5	209	3	meantime	meantime	NN
cord-016293-pyb00pt5	209	4	Haseltine	Haseltine	NNP
cord-016293-pyb00pt5	209	5	's	's	POS
cord-016293-pyb00pt5	209	6	partner	partner	NN
cord-016293-pyb00pt5	209	7	in	in	IN
cord-016293-pyb00pt5	209	8	rewriting	rewrite	VBG
cord-016293-pyb00pt5	209	9	patenting	patent	VBG
cord-016293-pyb00pt5	209	10	history	history	NN
cord-016293-pyb00pt5	209	11	,	,	,
cord-016293-pyb00pt5	209	12	Venter	Venter	NNP
cord-016293-pyb00pt5	209	13	turned	turn	VBD
cord-016293-pyb00pt5	209	14	his	-PRON-	PRP$
cord-016293-pyb00pt5	209	15	focus	focus	NN
cord-016293-pyb00pt5	209	16	to	to	IN
cord-016293-pyb00pt5	209	17	the	the	DT
cord-016293-pyb00pt5	209	18	human	human	JJ
cord-016293-pyb00pt5	209	19	genome	genome	NN
cord-016293-pyb00pt5	209	20	.	.	.
cord-016293-pyb00pt5	210	1	He	-PRON-	PRP
cord-016293-pyb00pt5	210	2	left	leave	VBD
cord-016293-pyb00pt5	210	3	TIGR	TIGR	NNP
cord-016293-pyb00pt5	210	4	and	and	CC
cord-016293-pyb00pt5	210	5	started	start	VBD
cord-016293-pyb00pt5	210	6	the	the	DT
cord-016293-pyb00pt5	210	7	for	for	IN
cord-016293-pyb00pt5	210	8	-	-	HYPH
cord-016293-pyb00pt5	210	9	profit	profit	NN
cord-016293-pyb00pt5	210	10	company	company	NN
cord-016293-pyb00pt5	210	11	Celera	Celera	NNP
cord-016293-pyb00pt5	210	12	,	,	,
cord-016293-pyb00pt5	210	13	a	a	DT
cord-016293-pyb00pt5	210	14	division	division	NN
cord-016293-pyb00pt5	210	15	of	of	IN
cord-016293-pyb00pt5	210	16	PE	PE	NNP
cord-016293-pyb00pt5	210	17	Biosystems	Biosystems	NNP
cord-016293-pyb00pt5	210	18	,	,	,
cord-016293-pyb00pt5	210	19	the	the	DT
cord-016293-pyb00pt5	210	20	company	company	NN
cord-016293-pyb00pt5	210	21	that	that	IN
cord-016293-pyb00pt5	210	22	at	at	IN
cord-016293-pyb00pt5	210	23	times	time	NNS
cord-016293-pyb00pt5	210	24	,	,	,
cord-016293-pyb00pt5	210	25	thanks	thank	NNS
cord-016293-pyb00pt5	210	26	to	to	IN
cord-016293-pyb00pt5	210	27	Hood	Hood	NNP
cord-016293-pyb00pt5	210	28	and	and	CC
cord-016293-pyb00pt5	210	29	Hunkapillar	Hunkapillar	NNP
cord-016293-pyb00pt5	210	30	,	,	,
cord-016293-pyb00pt5	210	31	led	lead	VBD
cord-016293-pyb00pt5	210	32	the	the	DT
cord-016293-pyb00pt5	210	33	world	world	NN
cord-016293-pyb00pt5	210	34	in	in	IN
cord-016293-pyb00pt5	210	35	the	the	DT
cord-016293-pyb00pt5	210	36	production	production	NN
cord-016293-pyb00pt5	210	37	of	of	IN
cord-016293-pyb00pt5	210	38	sequencing	sequence	VBG
cord-016293-pyb00pt5	210	39	machines	machine	NNS
cord-016293-pyb00pt5	210	40	.	.	.
cord-016293-pyb00pt5	211	1	Using	use	VBG
cord-016293-pyb00pt5	211	2	these	these	DT
cord-016293-pyb00pt5	211	3	machines	machine	NNS
cord-016293-pyb00pt5	211	4	,	,	,
cord-016293-pyb00pt5	211	5	and	and	CC
cord-016293-pyb00pt5	211	6	the	the	DT
cord-016293-pyb00pt5	211	7	world	world	NN
cord-016293-pyb00pt5	211	8	's	's	POS
cord-016293-pyb00pt5	211	9	largest	large	JJS
cord-016293-pyb00pt5	211	10	civilian	civilian	JJ
cord-016293-pyb00pt5	211	11	supercomputer	supercomputer	NN
cord-016293-pyb00pt5	211	12	,	,	,
cord-016293-pyb00pt5	211	13	Venter	Venter	NNP
cord-016293-pyb00pt5	211	14	finished	finish	VBD
cord-016293-pyb00pt5	211	15	assembling	assemble	VBG
cord-016293-pyb00pt5	211	16	the	the	DT
cord-016293-pyb00pt5	211	17	human	human	JJ
cord-016293-pyb00pt5	211	18	genome	genome	NN
cord-016293-pyb00pt5	211	19	in	in	IN
cord-016293-pyb00pt5	211	20	just	just	RB
cord-016293-pyb00pt5	211	21	three	three	CD
cord-016293-pyb00pt5	211	22	years	year	NNS
cord-016293-pyb00pt5	211	23	.	.	.
cord-016293-pyb00pt5	212	1	Following	follow	VBG
cord-016293-pyb00pt5	212	2	the	the	DT
cord-016293-pyb00pt5	212	3	debacle	debacle	NN
cord-016293-pyb00pt5	212	4	with	with	IN
cord-016293-pyb00pt5	212	5	the	the	DT
cord-016293-pyb00pt5	212	6	then	then	RB
cord-016293-pyb00pt5	212	7	NIH	NIH	NNP
cord-016293-pyb00pt5	212	8	director	director	NN
cord-016293-pyb00pt5	212	9	Bernine	Bernine	NNP
cord-016293-pyb00pt5	212	10	Healy	Healy	NNP
cord-016293-pyb00pt5	212	11	over	over	IN
cord-016293-pyb00pt5	212	12	patenting	patent	VBG
cord-016293-pyb00pt5	212	13	the	the	DT
cord-016293-pyb00pt5	212	14	partial	partial	JJ
cord-016293-pyb00pt5	212	15	genes	gene	NNS
cord-016293-pyb00pt5	212	16	that	that	WDT
cord-016293-pyb00pt5	212	17	resulted	result	VBD
cord-016293-pyb00pt5	212	18	from	from	IN
cord-016293-pyb00pt5	212	19	EST	EST	NNP
cord-016293-pyb00pt5	212	20	analysis	analysis	NN
cord-016293-pyb00pt5	212	21	,	,	,
cord-016293-pyb00pt5	212	22	another	another	DT
cord-016293-pyb00pt5	212	23	major	major	JJ
cord-016293-pyb00pt5	212	24	personality	personality	NN
cord-016293-pyb00pt5	212	25	-	-	HYPH
cord-016293-pyb00pt5	212	26	driven	drive	VBN
cord-016293-pyb00pt5	212	27	event	event	NN
cord-016293-pyb00pt5	212	28	in	in	IN
cord-016293-pyb00pt5	212	29	that	that	DT
cord-016293-pyb00pt5	212	30	same	same	JJ
cord-016293-pyb00pt5	212	31	year	year	NN
cord-016293-pyb00pt5	212	32	occurred	occur	VBD
cord-016293-pyb00pt5	212	33	.	.	.
cord-016293-pyb00pt5	213	1	Watson	Watson	NNP
cord-016293-pyb00pt5	213	2	strongly	strongly	RB
cord-016293-pyb00pt5	213	3	opposed	oppose	VBD
cord-016293-pyb00pt5	213	4	the	the	DT
cord-016293-pyb00pt5	213	5	idea	idea	NN
cord-016293-pyb00pt5	213	6	of	of	IN
cord-016293-pyb00pt5	213	7	patenting	patent	VBG
cord-016293-pyb00pt5	213	8	gene	gene	NN
cord-016293-pyb00pt5	213	9	fragments	fragment	NNS
cord-016293-pyb00pt5	213	10	fearing	fear	VBG
cord-016293-pyb00pt5	213	11	that	that	IN
cord-016293-pyb00pt5	213	12	it	-PRON-	PRP
cord-016293-pyb00pt5	213	13	would	would	MD
cord-016293-pyb00pt5	213	14	discourage	discourage	VB
cord-016293-pyb00pt5	213	15	research	research	NN
cord-016293-pyb00pt5	213	16	,	,	,
cord-016293-pyb00pt5	213	17	and	and	CC
cord-016293-pyb00pt5	213	18	commented	comment	VBD
cord-016293-pyb00pt5	213	19	that	that	IN
cord-016293-pyb00pt5	213	20	"	"	``
cord-016293-pyb00pt5	213	21	the	the	DT
cord-016293-pyb00pt5	213	22	automated	automate	VBN
cord-016293-pyb00pt5	213	23	sequencing	sequencing	NN
cord-016293-pyb00pt5	213	24	machines	machine	NNS
cord-016293-pyb00pt5	213	25	'	'	POS
cord-016293-pyb00pt5	213	26	could	could	MD
cord-016293-pyb00pt5	213	27	be	be	VB
cord-016293-pyb00pt5	213	28	run	run	VBN
cord-016293-pyb00pt5	213	29	by	by	IN
cord-016293-pyb00pt5	213	30	monkeys	monkey	NNS
cord-016293-pyb00pt5	213	31	.	.	.
cord-016293-pyb00pt5	213	32	'	'	''
cord-016293-pyb00pt5	213	33	"	"	''
cord-016293-pyb00pt5	214	1	(	(	-LRB-
cord-016293-pyb00pt5	214	2	Nature	Nature	NNP
cord-016293-pyb00pt5	214	3	June	June	NNP
cord-016293-pyb00pt5	214	4	29	29	CD
cord-016293-pyb00pt5	214	5	,	,	,
cord-016293-pyb00pt5	214	6	2000	2000	CD
cord-016293-pyb00pt5	214	7	)	)	-RRB-
cord-016293-pyb00pt5	214	8	with	with	IN
cord-016293-pyb00pt5	214	9	this	this	DT
cord-016293-pyb00pt5	214	10	dismissal	dismissal	NN
cord-016293-pyb00pt5	215	1	Watson	Watson	NNP
cord-016293-pyb00pt5	215	2	resigned	resign	VBD
cord-016293-pyb00pt5	215	3	his	-PRON-	PRP$
cord-016293-pyb00pt5	215	4	NIH	NIH	NNP
cord-016293-pyb00pt5	215	5	NCHGR	NCHGR	NNP
cord-016293-pyb00pt5	215	6	post	post	NN
cord-016293-pyb00pt5	215	7	in	in	IN
cord-016293-pyb00pt5	215	8	1992	1992	CD
cord-016293-pyb00pt5	215	9	to	to	TO
cord-016293-pyb00pt5	215	10	devote	devote	VB
cord-016293-pyb00pt5	215	11	his	-PRON-	PRP$
cord-016293-pyb00pt5	215	12	full	full	JJ
cord-016293-pyb00pt5	215	13	-	-	HYPH
cord-016293-pyb00pt5	215	14	time	time	NN
cord-016293-pyb00pt5	215	15	effort	effort	NN
cord-016293-pyb00pt5	215	16	to	to	IN
cord-016293-pyb00pt5	215	17	directing	direct	VBG
cord-016293-pyb00pt5	215	18	Cold	Cold	NNP
cord-016293-pyb00pt5	215	19	Spring	Spring	NNP
cord-016293-pyb00pt5	215	20	Harbor	Harbor	NNP
cord-016293-pyb00pt5	215	21	Laboratory	Laboratory	NNP
cord-016293-pyb00pt5	215	22	.	.	.
cord-016293-pyb00pt5	216	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	216	2	replacement	replacement	NN
cord-016293-pyb00pt5	216	3	was	be	VBD
cord-016293-pyb00pt5	216	4	of	of	IN
cord-016293-pyb00pt5	216	5	a	a	DT
cord-016293-pyb00pt5	216	6	rather	rather	RB
cord-016293-pyb00pt5	216	7	more	more	RBR
cord-016293-pyb00pt5	216	8	pragmatic	pragmatic	JJ
cord-016293-pyb00pt5	216	9	,	,	,
cord-016293-pyb00pt5	216	10	less	less	RBR
cord-016293-pyb00pt5	216	11	flamboyant	flamboyant	JJ
cord-016293-pyb00pt5	216	12	nature	nature	NN
cord-016293-pyb00pt5	216	13	.	.	.
cord-016293-pyb00pt5	217	1	While	while	IN
cord-016293-pyb00pt5	217	2	Venter	Venter	NNP
cord-016293-pyb00pt5	217	3	maybe	maybe	RB
cord-016293-pyb00pt5	217	4	was	be	VBD
cord-016293-pyb00pt5	217	5	described	describe	VBN
cord-016293-pyb00pt5	217	6	as	as	IN
cord-016293-pyb00pt5	217	7	an	an	DT
cord-016293-pyb00pt5	217	8	idiosyncratic	idiosyncratic	JJ
cord-016293-pyb00pt5	217	9	Shogun	Shogun	NNP
cord-016293-pyb00pt5	217	10	of	of	IN
cord-016293-pyb00pt5	217	11	the	the	DT
cord-016293-pyb00pt5	217	12	shotgun	shotgun	NN
cord-016293-pyb00pt5	217	13	,	,	,
cord-016293-pyb00pt5	217	14	Francis	Francis	NNP
cord-016293-pyb00pt5	217	15	Collins	Collins	NNP
cord-016293-pyb00pt5	217	16	was	be	VBD
cord-016293-pyb00pt5	217	17	once	once	RB
cord-016293-pyb00pt5	217	18	described	describe	VBN
cord-016293-pyb00pt5	217	19	as	as	IN
cord-016293-pyb00pt5	217	20	the	the	DT
cord-016293-pyb00pt5	217	21	King	King	NNP
cord-016293-pyb00pt5	217	22	Arthur	Arthur	NNP
cord-016293-pyb00pt5	217	23	of	of	IN
cord-016293-pyb00pt5	217	24	the	the	DT
cord-016293-pyb00pt5	217	25	Holy	Holy	NNP
cord-016293-pyb00pt5	217	26	Grail	Grail	NNP
cord-016293-pyb00pt5	217	27	that	that	WDT
cord-016293-pyb00pt5	217	28	is	be	VBZ
cord-016293-pyb00pt5	217	29	the	the	DT
cord-016293-pyb00pt5	217	30	Human	Human	NNP
cord-016293-pyb00pt5	217	31	Genome	Genome	NNP
cord-016293-pyb00pt5	217	32	Project	Project	NNP
cord-016293-pyb00pt5	217	33	.	.	.
cord-016293-pyb00pt5	218	1	Collins	Collins	NNP
cord-016293-pyb00pt5	218	2	became	become	VBD
cord-016293-pyb00pt5	218	3	the	the	DT
cord-016293-pyb00pt5	218	4	Director	Director	NNP
cord-016293-pyb00pt5	218	5	of	of	IN
cord-016293-pyb00pt5	218	6	the	the	DT
cord-016293-pyb00pt5	218	7	National	National	NNP
cord-016293-pyb00pt5	218	8	Human	Human	NNP
cord-016293-pyb00pt5	218	9	Genome	Genome	NNP
cord-016293-pyb00pt5	218	10	Research	Research	NNP
cord-016293-pyb00pt5	218	11	Institute	Institute	NNP
cord-016293-pyb00pt5	218	12	in	in	IN
cord-016293-pyb00pt5	218	13	1993	1993	CD
cord-016293-pyb00pt5	218	14	.	.	.
cord-016293-pyb00pt5	219	1	He	-PRON-	PRP
cord-016293-pyb00pt5	219	2	was	be	VBD
cord-016293-pyb00pt5	219	3	considered	consider	VBN
cord-016293-pyb00pt5	219	4	the	the	DT
cord-016293-pyb00pt5	219	5	right	right	JJ
cord-016293-pyb00pt5	219	6	man	man	NN
cord-016293-pyb00pt5	219	7	for	for	IN
cord-016293-pyb00pt5	219	8	the	the	DT
cord-016293-pyb00pt5	219	9	job	job	NN
cord-016293-pyb00pt5	219	10	following	follow	VBG
cord-016293-pyb00pt5	219	11	his	-PRON-	PRP$
cord-016293-pyb00pt5	219	12	1989	1989	CD
cord-016293-pyb00pt5	219	13	success	success	NN
cord-016293-pyb00pt5	219	14	(	(	-LRB-
cord-016293-pyb00pt5	219	15	along	along	IN
cord-016293-pyb00pt5	219	16	with	with	IN
cord-016293-pyb00pt5	219	17	Lap	Lap	NNP
cord-016293-pyb00pt5	219	18	-	-	HYPH
cord-016293-pyb00pt5	219	19	Chee	Chee	NNP
cord-016293-pyb00pt5	219	20	Tsui	Tsui	NNP
cord-016293-pyb00pt5	219	21	)	)	-RRB-
cord-016293-pyb00pt5	219	22	in	in	IN
cord-016293-pyb00pt5	219	23	identifying	identify	VBG
cord-016293-pyb00pt5	219	24	the	the	DT
cord-016293-pyb00pt5	219	25	gene	gene	NN
cord-016293-pyb00pt5	219	26	for	for	IN
cord-016293-pyb00pt5	219	27	the	the	DT
cord-016293-pyb00pt5	219	28	cystic	cystic	JJ
cord-016293-pyb00pt5	219	29	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	219	30	transmembrane	transmembrane	NNP
cord-016293-pyb00pt5	219	31	(	(	-LRB-
cord-016293-pyb00pt5	219	32	CFTR	CFTR	NNP
cord-016293-pyb00pt5	219	33	)	)	-RRB-
cord-016293-pyb00pt5	219	34	chloride	chloride	NN
cord-016293-pyb00pt5	219	35	channel	channel	NN
cord-016293-pyb00pt5	219	36	receptor	receptor	NN
cord-016293-pyb00pt5	219	37	that	that	WDT
cord-016293-pyb00pt5	219	38	,	,	,
cord-016293-pyb00pt5	219	39	when	when	WRB
cord-016293-pyb00pt5	219	40	mutated	mutate	VBN
cord-016293-pyb00pt5	219	41	,	,	,
cord-016293-pyb00pt5	219	42	can	can	MD
cord-016293-pyb00pt5	219	43	lead	lead	VB
cord-016293-pyb00pt5	219	44	to	to	IN
cord-016293-pyb00pt5	219	45	the	the	DT
cord-016293-pyb00pt5	219	46	onset	onset	NN
cord-016293-pyb00pt5	219	47	of	of	IN
cord-016293-pyb00pt5	219	48	cystic	cystic	JJ
cord-016293-pyb00pt5	219	49	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	219	50	.	.	.
cord-016293-pyb00pt5	220	1	Although	although	IN
cord-016293-pyb00pt5	220	2	now	now	RB
cord-016293-pyb00pt5	220	3	indelibly	indelibly	RB
cord-016293-pyb00pt5	220	4	connected	connect	VBN
cord-016293-pyb00pt5	220	5	with	with	IN
cord-016293-pyb00pt5	220	6	the	the	DT
cord-016293-pyb00pt5	220	7	topic	topic	NN
cord-016293-pyb00pt5	220	8	non	non	JJ
cord-016293-pyb00pt5	220	9	-	-	JJ
cord-016293-pyb00pt5	220	10	plus	plus	CC
cord-016293-pyb00pt5	220	11	tout	tout	NN
cord-016293-pyb00pt5	220	12	in	in	IN
cord-016293-pyb00pt5	220	13	biology	biology	NN
cord-016293-pyb00pt5	220	14	,	,	,
cord-016293-pyb00pt5	220	15	like	like	IN
cord-016293-pyb00pt5	220	16	many	many	JJ
cord-016293-pyb00pt5	220	17	great	great	JJ
cord-016293-pyb00pt5	220	18	innovators	innovator	NNS
cord-016293-pyb00pt5	220	19	in	in	IN
cord-016293-pyb00pt5	220	20	this	this	DT
cord-016293-pyb00pt5	220	21	field	field	NN
cord-016293-pyb00pt5	220	22	before	before	IN
cord-016293-pyb00pt5	220	23	him	-PRON-	PRP
cord-016293-pyb00pt5	220	24	,	,	,
cord-016293-pyb00pt5	220	25	Francis	Francis	NNP
cord-016293-pyb00pt5	220	26	Collins	Collins	NNP
cord-016293-pyb00pt5	220	27	had	have	VBD
cord-016293-pyb00pt5	220	28	little	little	JJ
cord-016293-pyb00pt5	220	29	interest	interest	NN
cord-016293-pyb00pt5	220	30	in	in	IN
cord-016293-pyb00pt5	220	31	biology	biology	NN
cord-016293-pyb00pt5	220	32	as	as	IN
cord-016293-pyb00pt5	220	33	he	-PRON-	PRP
cord-016293-pyb00pt5	220	34	grew	grow	VBD
cord-016293-pyb00pt5	220	35	up	up	RP
cord-016293-pyb00pt5	220	36	on	on	IN
cord-016293-pyb00pt5	220	37	a	a	DT
cord-016293-pyb00pt5	220	38	farm	farm	NN
cord-016293-pyb00pt5	220	39	in	in	IN
cord-016293-pyb00pt5	220	40	the	the	DT
cord-016293-pyb00pt5	220	41	Shenandoah	Shenandoah	NNP
cord-016293-pyb00pt5	220	42	Valley	Valley	NNP
cord-016293-pyb00pt5	220	43	of	of	IN
cord-016293-pyb00pt5	220	44	Virginia	Virginia	NNP
cord-016293-pyb00pt5	220	45	.	.	.
cord-016293-pyb00pt5	221	1	From	from	IN
cord-016293-pyb00pt5	221	2	his	-PRON-	PRP$
cord-016293-pyb00pt5	221	3	childhood	childhood	NN
cord-016293-pyb00pt5	221	4	he	-PRON-	PRP
cord-016293-pyb00pt5	221	5	seemed	seem	VBD
cord-016293-pyb00pt5	221	6	destined	destine	VBN
cord-016293-pyb00pt5	221	7	to	to	TO
cord-016293-pyb00pt5	221	8	be	be	VB
cord-016293-pyb00pt5	221	9	at	at	IN
cord-016293-pyb00pt5	221	10	the	the	DT
cord-016293-pyb00pt5	221	11	center	center	NN
cord-016293-pyb00pt5	221	12	of	of	IN
cord-016293-pyb00pt5	221	13	drama	drama	NN
cord-016293-pyb00pt5	221	14	,	,	,
cord-016293-pyb00pt5	221	15	his	-PRON-	PRP$
cord-016293-pyb00pt5	221	16	father	father	NN
cord-016293-pyb00pt5	221	17	was	be	VBD
cord-016293-pyb00pt5	221	18	professor	professor	NN
cord-016293-pyb00pt5	221	19	of	of	IN
cord-016293-pyb00pt5	221	20	dramatic	dramatic	JJ
cord-016293-pyb00pt5	221	21	arts	art	NNS
cord-016293-pyb00pt5	221	22	at	at	IN
cord-016293-pyb00pt5	221	23	Mary	Mary	NNP
cord-016293-pyb00pt5	221	24	Baldwin	Baldwin	NNP
cord-016293-pyb00pt5	221	25	College	College	NNP
cord-016293-pyb00pt5	221	26	and	and	CC
cord-016293-pyb00pt5	221	27	the	the	DT
cord-016293-pyb00pt5	221	28	early	early	JJ
cord-016293-pyb00pt5	221	29	stage	stage	NN
cord-016293-pyb00pt5	221	30	management	management	NN
cord-016293-pyb00pt5	221	31	of	of	IN
cord-016293-pyb00pt5	221	32	career	career	NN
cord-016293-pyb00pt5	221	33	was	be	VBD
cord-016293-pyb00pt5	221	34	performed	perform	VBN
cord-016293-pyb00pt5	221	35	on	on	IN
cord-016293-pyb00pt5	221	36	a	a	DT
cord-016293-pyb00pt5	221	37	stage	stage	NN
cord-016293-pyb00pt5	221	38	he	-PRON-	PRP
cord-016293-pyb00pt5	221	39	built	build	VBD
cord-016293-pyb00pt5	221	40	on	on	IN
cord-016293-pyb00pt5	221	41	the	the	DT
cord-016293-pyb00pt5	221	42	farm	farm	NN
cord-016293-pyb00pt5	221	43	.	.	.
cord-016293-pyb00pt5	222	1	While	while	IN
cord-016293-pyb00pt5	222	2	the	the	DT
cord-016293-pyb00pt5	222	3	physical	physical	JJ
cord-016293-pyb00pt5	222	4	and	and	CC
cord-016293-pyb00pt5	222	5	mathematical	mathematical	JJ
cord-016293-pyb00pt5	222	6	sciences	science	NNS
cord-016293-pyb00pt5	222	7	held	hold	VBD
cord-016293-pyb00pt5	222	8	appeal	appeal	NN
cord-016293-pyb00pt5	222	9	for	for	IN
cord-016293-pyb00pt5	222	10	him	-PRON-	PRP
cord-016293-pyb00pt5	222	11	,	,	,
cord-016293-pyb00pt5	222	12	being	be	VBG
cord-016293-pyb00pt5	222	13	possessed	possess	VBN
cord-016293-pyb00pt5	222	14	of	of	IN
cord-016293-pyb00pt5	222	15	a	a	DT
cord-016293-pyb00pt5	222	16	highly	highly	RB
cord-016293-pyb00pt5	222	17	logical	logical	JJ
cord-016293-pyb00pt5	222	18	mind	mind	NN
cord-016293-pyb00pt5	222	19	,	,	,
cord-016293-pyb00pt5	222	20	Collins	Collins	NNP
cord-016293-pyb00pt5	222	21	found	find	VBD
cord-016293-pyb00pt5	222	22	the	the	DT
cord-016293-pyb00pt5	222	23	format	format	NN
cord-016293-pyb00pt5	222	24	in	in	IN
cord-016293-pyb00pt5	222	25	which	which	WDT
cord-016293-pyb00pt5	222	26	biology	biology	NN
cord-016293-pyb00pt5	222	27	was	be	VBD
cord-016293-pyb00pt5	222	28	taught	teach	VBN
cord-016293-pyb00pt5	222	29	in	in	IN
cord-016293-pyb00pt5	222	30	the	the	DT
cord-016293-pyb00pt5	222	31	high	high	JJ
cord-016293-pyb00pt5	222	32	school	school	NN
cord-016293-pyb00pt5	222	33	of	of	IN
cord-016293-pyb00pt5	222	34	his	-PRON-	PRP$
cord-016293-pyb00pt5	222	35	day	day	NN
cord-016293-pyb00pt5	222	36	mind	mind	NN
cord-016293-pyb00pt5	222	37	-	-	:
cord-016293-pyb00pt5	222	38	numbingly	numbingly	RB
cord-016293-pyb00pt5	222	39	boring	boring	JJ
cord-016293-pyb00pt5	222	40	,	,	,
cord-016293-pyb00pt5	222	41	filled	fill	VBN
cord-016293-pyb00pt5	222	42	with	with	IN
cord-016293-pyb00pt5	222	43	dissections	dissection	NNS
cord-016293-pyb00pt5	222	44	and	and	CC
cord-016293-pyb00pt5	222	45	rote	rote	JJ
cord-016293-pyb00pt5	222	46	memorization	memorization	NN
cord-016293-pyb00pt5	222	47	.	.	.
cord-016293-pyb00pt5	223	1	He	-PRON-	PRP
cord-016293-pyb00pt5	223	2	found	find	VBD
cord-016293-pyb00pt5	223	3	the	the	DT
cord-016293-pyb00pt5	223	4	contemplation	contemplation	NN
cord-016293-pyb00pt5	223	5	of	of	IN
cord-016293-pyb00pt5	223	6	the	the	DT
cord-016293-pyb00pt5	223	7	infinite	infinite	JJ
cord-016293-pyb00pt5	223	8	outcomes	outcome	NNS
cord-016293-pyb00pt5	223	9	of	of	IN
cord-016293-pyb00pt5	223	10	dividing	divide	VBG
cord-016293-pyb00pt5	223	11	by	by	IN
cord-016293-pyb00pt5	223	12	zero	zero	CD
cord-016293-pyb00pt5	223	13	(	(	-LRB-
cord-016293-pyb00pt5	223	14	done	do	VBN
cord-016293-pyb00pt5	223	15	deliberately	deliberately	RB
cord-016293-pyb00pt5	223	16	rather	rather	RB
cord-016293-pyb00pt5	223	17	than	than	IN
cord-016293-pyb00pt5	223	18	by	by	IN
cord-016293-pyb00pt5	223	19	accident	accident	NN
cord-016293-pyb00pt5	223	20	as	as	IN
cord-016293-pyb00pt5	223	21	in	in	IN
cord-016293-pyb00pt5	223	22	Einstein	Einstein	NNP
cord-016293-pyb00pt5	223	23	's	's	POS
cord-016293-pyb00pt5	223	24	case	case	NN
cord-016293-pyb00pt5	223	25	)	)	-RRB-
cord-016293-pyb00pt5	223	26	far	far	RB
cord-016293-pyb00pt5	223	27	more	more	RBR
cord-016293-pyb00pt5	223	28	appealing	appealing	JJ
cord-016293-pyb00pt5	223	29	than	than	IN
cord-016293-pyb00pt5	223	30	contemplating	contemplate	VBG
cord-016293-pyb00pt5	223	31	the	the	DT
cord-016293-pyb00pt5	223	32	innards	innard	NNS
cord-016293-pyb00pt5	223	33	of	of	IN
cord-016293-pyb00pt5	223	34	a	a	DT
cord-016293-pyb00pt5	223	35	frog	frog	NN
cord-016293-pyb00pt5	223	36	.	.	.
cord-016293-pyb00pt5	224	1	That	that	DT
cord-016293-pyb00pt5	224	2	biology	biology	NN
cord-016293-pyb00pt5	224	3	could	could	MD
cord-016293-pyb00pt5	224	4	be	be	VB
cord-016293-pyb00pt5	224	5	gloriously	gloriously	RB
cord-016293-pyb00pt5	224	6	logical	logical	JJ
cord-016293-pyb00pt5	224	7	only	only	RB
cord-016293-pyb00pt5	224	8	became	become	VBD
cord-016293-pyb00pt5	224	9	clear	clear	JJ
cord-016293-pyb00pt5	224	10	to	to	IN
cord-016293-pyb00pt5	224	11	Collins	Collins	NNP
cord-016293-pyb00pt5	224	12	when	when	WRB
cord-016293-pyb00pt5	224	13	,	,	,
cord-016293-pyb00pt5	224	14	in	in	IN
cord-016293-pyb00pt5	224	15	1970	1970	CD
cord-016293-pyb00pt5	224	16	,	,	,
cord-016293-pyb00pt5	224	17	he	-PRON-	PRP
cord-016293-pyb00pt5	224	18	entered	enter	VBD
cord-016293-pyb00pt5	224	19	Yale	Yale	NNP
cord-016293-pyb00pt5	224	20	with	with	IN
cord-016293-pyb00pt5	224	21	a	a	DT
cord-016293-pyb00pt5	224	22	degree	degree	NN
cord-016293-pyb00pt5	224	23	in	in	IN
cord-016293-pyb00pt5	224	24	chemistry	chemistry	NN
cord-016293-pyb00pt5	224	25	from	from	IN
cord-016293-pyb00pt5	224	26	the	the	DT
cord-016293-pyb00pt5	224	27	University	University	NNP
cord-016293-pyb00pt5	224	28	of	of	IN
cord-016293-pyb00pt5	224	29	Virginia	Virginia	NNP
cord-016293-pyb00pt5	224	30	and	and	CC
cord-016293-pyb00pt5	224	31	was	be	VBD
cord-016293-pyb00pt5	224	32	first	first	RB
cord-016293-pyb00pt5	224	33	exposed	expose	VBN
cord-016293-pyb00pt5	224	34	to	to	IN
cord-016293-pyb00pt5	224	35	the	the	DT
cord-016293-pyb00pt5	224	36	nascent	nascent	JJ
cord-016293-pyb00pt5	224	37	field	field	NN
cord-016293-pyb00pt5	224	38	of	of	IN
cord-016293-pyb00pt5	224	39	molecular	molecular	JJ
cord-016293-pyb00pt5	224	40	biology	biology	NN
cord-016293-pyb00pt5	224	41	.	.	.
cord-016293-pyb00pt5	225	1	Anecdotally	anecdotally	RB
cord-016293-pyb00pt5	225	2	it	-PRON-	PRP
cord-016293-pyb00pt5	225	3	was	be	VBD
cord-016293-pyb00pt5	225	4	the	the	DT
cord-016293-pyb00pt5	225	5	tome	tome	NN
cord-016293-pyb00pt5	225	6	,	,	,
cord-016293-pyb00pt5	225	7	the	the	DT
cord-016293-pyb00pt5	225	8	Book	Book	NNP
cord-016293-pyb00pt5	225	9	of	of	IN
cord-016293-pyb00pt5	225	10	Life	Life	NNP
cord-016293-pyb00pt5	225	11	,	,	,
cord-016293-pyb00pt5	225	12	penned	pen	VBN
cord-016293-pyb00pt5	225	13	by	by	IN
cord-016293-pyb00pt5	225	14	the	the	DT
cord-016293-pyb00pt5	225	15	theoretical	theoretical	JJ
cord-016293-pyb00pt5	225	16	physicist	physicist	NN
cord-016293-pyb00pt5	225	17	father	father	NN
cord-016293-pyb00pt5	225	18	of	of	IN
cord-016293-pyb00pt5	225	19	molecular	molecular	JJ
cord-016293-pyb00pt5	225	20	biology	biology	NN
cord-016293-pyb00pt5	225	21	,	,	,
cord-016293-pyb00pt5	225	22	Edwin	Edwin	NNP
cord-016293-pyb00pt5	225	23	Schrodinger	Schrodinger	NNP
cord-016293-pyb00pt5	225	24	,	,	,
cord-016293-pyb00pt5	225	25	while	while	IN
cord-016293-pyb00pt5	225	26	exiled	exile	VBN
cord-016293-pyb00pt5	225	27	in	in	IN
cord-016293-pyb00pt5	225	28	Trinity	Trinity	NNP
cord-016293-pyb00pt5	225	29	College	College	NNP
cord-016293-pyb00pt5	225	30	Dublin	Dublin	NNP
cord-016293-pyb00pt5	225	31	in	in	IN
cord-016293-pyb00pt5	225	32	1942	1942	CD
cord-016293-pyb00pt5	225	33	that	that	WDT
cord-016293-pyb00pt5	225	34	was	be	VBD
cord-016293-pyb00pt5	225	35	the	the	DT
cord-016293-pyb00pt5	225	36	catalyst	catalyst	NN
cord-016293-pyb00pt5	225	37	for	for	IN
cord-016293-pyb00pt5	225	38	his	-PRON-	PRP$
cord-016293-pyb00pt5	225	39	conversion	conversion	NN
cord-016293-pyb00pt5	225	40	.	.	.
cord-016293-pyb00pt5	226	1	Like	like	IN
cord-016293-pyb00pt5	226	2	Schrodinger	Schrodinger	NNP
cord-016293-pyb00pt5	226	3	he	-PRON-	PRP
cord-016293-pyb00pt5	226	4	wanted	want	VBD
cord-016293-pyb00pt5	226	5	to	to	TO
cord-016293-pyb00pt5	226	6	do	do	VB
cord-016293-pyb00pt5	226	7	something	something	NN
cord-016293-pyb00pt5	226	8	more	more	RBR
cord-016293-pyb00pt5	226	9	obviously	obviously	RB
cord-016293-pyb00pt5	226	10	meaningful	meaningful	JJ
cord-016293-pyb00pt5	226	11	(	(	-LRB-
cord-016293-pyb00pt5	226	12	for	for	IN
cord-016293-pyb00pt5	226	13	less	less	JJR
cord-016293-pyb00pt5	226	14	than	than	IN
cord-016293-pyb00pt5	226	15	hardcore	hardcore	JJ
cord-016293-pyb00pt5	226	16	physicists	physicist	NNS
cord-016293-pyb00pt5	226	17	at	at	IN
cord-016293-pyb00pt5	226	18	least	least	JJS
cord-016293-pyb00pt5	226	19	!	!	.
cord-016293-pyb00pt5	226	20	)	)	-RRB-
cord-016293-pyb00pt5	227	1	than	than	IN
cord-016293-pyb00pt5	227	2	theoretical	theoretical	JJ
cord-016293-pyb00pt5	227	3	physics	physics	NN
cord-016293-pyb00pt5	227	4	,	,	,
cord-016293-pyb00pt5	227	5	so	so	RB
cord-016293-pyb00pt5	227	6	he	-PRON-	PRP
cord-016293-pyb00pt5	227	7	went	go	VBD
cord-016293-pyb00pt5	227	8	to	to	IN
cord-016293-pyb00pt5	227	9	medical	medical	JJ
cord-016293-pyb00pt5	227	10	school	school	NN
cord-016293-pyb00pt5	227	11	at	at	IN
cord-016293-pyb00pt5	227	12	UNC	UNC	NNP
cord-016293-pyb00pt5	227	13	-	-	HYPH
cord-016293-pyb00pt5	227	14	Chapel	Chapel	NNP
cord-016293-pyb00pt5	227	15	Hill	Hill	NNP
cord-016293-pyb00pt5	227	16	after	after	IN
cord-016293-pyb00pt5	227	17	completing	complete	VBG
cord-016293-pyb00pt5	227	18	his	-PRON-	PRP$
cord-016293-pyb00pt5	227	19	chemistry	chemistry	NN
cord-016293-pyb00pt5	227	20	doctorate	doctorate	NN
cord-016293-pyb00pt5	227	21	in	in	IN
cord-016293-pyb00pt5	227	22	Yale	Yale	NNP
cord-016293-pyb00pt5	227	23	,	,	,
cord-016293-pyb00pt5	227	24	and	and	CC
cord-016293-pyb00pt5	227	25	returned	return	VBD
cord-016293-pyb00pt5	227	26	to	to	IN
cord-016293-pyb00pt5	227	27	the	the	DT
cord-016293-pyb00pt5	227	28	site	site	NN
cord-016293-pyb00pt5	227	29	of	of	IN
cord-016293-pyb00pt5	227	30	his	-PRON-	PRP$
cord-016293-pyb00pt5	227	31	road	road	NN
cord-016293-pyb00pt5	227	32	to	to	IN
cord-016293-pyb00pt5	227	33	Damascus	Damascus	NNP
cord-016293-pyb00pt5	227	34	for	for	IN
cord-016293-pyb00pt5	227	35	post	post	JJ
cord-016293-pyb00pt5	227	36	-	-	JJ
cord-016293-pyb00pt5	227	37	doctoral	doctoral	JJ
cord-016293-pyb00pt5	227	38	study	study	NN
cord-016293-pyb00pt5	227	39	in	in	IN
cord-016293-pyb00pt5	227	40	the	the	DT
cord-016293-pyb00pt5	227	41	application	application	NN
cord-016293-pyb00pt5	227	42	of	of	IN
cord-016293-pyb00pt5	227	43	his	-PRON-	PRP$
cord-016293-pyb00pt5	227	44	newfound	newfound	NN
cord-016293-pyb00pt5	227	45	interest	interest	NN
cord-016293-pyb00pt5	227	46	in	in	IN
cord-016293-pyb00pt5	227	47	human	human	JJ
cord-016293-pyb00pt5	227	48	genetics	genetic	NNS
cord-016293-pyb00pt5	227	49	.	.	.
cord-016293-pyb00pt5	228	1	During	during	IN
cord-016293-pyb00pt5	228	2	this	this	DT
cord-016293-pyb00pt5	228	3	sojourn	sojourn	NN
cord-016293-pyb00pt5	228	4	at	at	IN
cord-016293-pyb00pt5	228	5	Yale	Yale	NNP
cord-016293-pyb00pt5	228	6	,	,	,
cord-016293-pyb00pt5	228	7	Collins	Collins	NNP
cord-016293-pyb00pt5	228	8	began	begin	VBD
cord-016293-pyb00pt5	228	9	working	work	VBG
cord-016293-pyb00pt5	228	10	on	on	IN
cord-016293-pyb00pt5	228	11	developing	develop	VBG
cord-016293-pyb00pt5	228	12	novel	novel	JJ
cord-016293-pyb00pt5	228	13	tools	tool	NNS
cord-016293-pyb00pt5	228	14	to	to	TO
cord-016293-pyb00pt5	228	15	search	search	VB
cord-016293-pyb00pt5	228	16	the	the	DT
cord-016293-pyb00pt5	228	17	genome	genome	NN
cord-016293-pyb00pt5	228	18	for	for	IN
cord-016293-pyb00pt5	228	19	genes	gene	NNS
cord-016293-pyb00pt5	228	20	that	that	WDT
cord-016293-pyb00pt5	228	21	cause	cause	VBP
cord-016293-pyb00pt5	228	22	human	human	JJ
cord-016293-pyb00pt5	228	23	disease	disease	NN
cord-016293-pyb00pt5	228	24	.	.	.
cord-016293-pyb00pt5	229	1	He	-PRON-	PRP
cord-016293-pyb00pt5	229	2	continued	continue	VBD
cord-016293-pyb00pt5	229	3	this	this	DT
cord-016293-pyb00pt5	229	4	work	work	NN
cord-016293-pyb00pt5	229	5	,	,	,
cord-016293-pyb00pt5	229	6	which	which	WDT
cord-016293-pyb00pt5	229	7	he	-PRON-	PRP
cord-016293-pyb00pt5	229	8	dubbed	dub	VBD
cord-016293-pyb00pt5	229	9	"	"	``
cord-016293-pyb00pt5	229	10	positional	positional	JJ
cord-016293-pyb00pt5	229	11	cloning	cloning	NN
cord-016293-pyb00pt5	229	12	,	,	,
cord-016293-pyb00pt5	229	13	"	"	''
cord-016293-pyb00pt5	229	14	after	after	IN
cord-016293-pyb00pt5	229	15	moving	move	VBG
cord-016293-pyb00pt5	229	16	to	to	IN
cord-016293-pyb00pt5	229	17	the	the	DT
cord-016293-pyb00pt5	229	18	University	University	NNP
cord-016293-pyb00pt5	229	19	of	of	IN
cord-016293-pyb00pt5	229	20	Michigan	Michigan	NNP
cord-016293-pyb00pt5	229	21	as	as	IN
cord-016293-pyb00pt5	229	22	a	a	DT
cord-016293-pyb00pt5	229	23	professor	professor	NN
cord-016293-pyb00pt5	229	24	in	in	IN
cord-016293-pyb00pt5	229	25	1984	1984	CD
cord-016293-pyb00pt5	229	26	.	.	.
cord-016293-pyb00pt5	230	1	He	-PRON-	PRP
cord-016293-pyb00pt5	230	2	placed	place	VBD
cord-016293-pyb00pt5	230	3	himself	-PRON-	PRP
cord-016293-pyb00pt5	230	4	on	on	IN
cord-016293-pyb00pt5	230	5	the	the	DT
cord-016293-pyb00pt5	230	6	genetic	genetic	JJ
cord-016293-pyb00pt5	230	7	map	map	NN
cord-016293-pyb00pt5	230	8	when	when	WRB
cord-016293-pyb00pt5	230	9	he	-PRON-	PRP
cord-016293-pyb00pt5	230	10	succeeded	succeed	VBD
cord-016293-pyb00pt5	230	11	in	in	IN
cord-016293-pyb00pt5	230	12	using	use	VBG
cord-016293-pyb00pt5	230	13	this	this	DT
cord-016293-pyb00pt5	230	14	method	method	NN
cord-016293-pyb00pt5	230	15	to	to	TO
cord-016293-pyb00pt5	230	16	put	put	VB
cord-016293-pyb00pt5	230	17	the	the	DT
cord-016293-pyb00pt5	230	18	gene	gene	NN
cord-016293-pyb00pt5	230	19	that	that	WDT
cord-016293-pyb00pt5	230	20	causes	cause	VBZ
cord-016293-pyb00pt5	230	21	cystic	cystic	JJ
cord-016293-pyb00pt5	230	22	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	230	23	on	on	IN
cord-016293-pyb00pt5	230	24	the	the	DT
cord-016293-pyb00pt5	230	25	physical	physical	JJ
cord-016293-pyb00pt5	230	26	map	map	NN
cord-016293-pyb00pt5	230	27	.	.	.
cord-016293-pyb00pt5	231	1	While	while	IN
cord-016293-pyb00pt5	231	2	a	a	DT
cord-016293-pyb00pt5	231	3	less	less	RBR
cord-016293-pyb00pt5	231	4	colorful	colorful	JJ
cord-016293-pyb00pt5	231	5	-	-	HYPH
cord-016293-pyb00pt5	231	6	in	in	IN
cord-016293-pyb00pt5	231	7	-	-	HYPH
cord-016293-pyb00pt5	231	8	your	-PRON-	PRP$
cord-016293-pyb00pt5	231	9	-	-	HYPH
cord-016293-pyb00pt5	231	10	face	face	NN
cord-016293-pyb00pt5	231	11	character	character	NN
cord-016293-pyb00pt5	231	12	than	than	IN
cord-016293-pyb00pt5	231	13	Venter	Venter	NNP
cord-016293-pyb00pt5	232	1	he	-PRON-	PRP
cord-016293-pyb00pt5	232	2	has	have	VBZ
cord-016293-pyb00pt5	232	3	his	-PRON-	PRP$
cord-016293-pyb00pt5	232	4	own	own	JJ
cord-016293-pyb00pt5	232	5	personality	personality	NN
cord-016293-pyb00pt5	232	6	quirks	quirk	NNS
cord-016293-pyb00pt5	232	7	,	,	,
cord-016293-pyb00pt5	233	1	for	for	IN
cord-016293-pyb00pt5	233	2	example	example	NN
cord-016293-pyb00pt5	233	3	,	,	,
cord-016293-pyb00pt5	233	4	he	-PRON-	PRP
cord-016293-pyb00pt5	233	5	pastes	paste	VBZ
cord-016293-pyb00pt5	233	6	a	a	DT
cord-016293-pyb00pt5	233	7	new	new	JJ
cord-016293-pyb00pt5	233	8	sticker	sticker	NN
cord-016293-pyb00pt5	233	9	onto	onto	IN
cord-016293-pyb00pt5	233	10	the	the	DT
cord-016293-pyb00pt5	233	11	back	back	NN
cord-016293-pyb00pt5	233	12	of	of	IN
cord-016293-pyb00pt5	233	13	his	-PRON-	PRP$
cord-016293-pyb00pt5	233	14	motorcycle	motorcycle	NN
cord-016293-pyb00pt5	233	15	helmet	helmet	NN
cord-016293-pyb00pt5	233	16	every	every	DT
cord-016293-pyb00pt5	233	17	time	time	NN
cord-016293-pyb00pt5	233	18	he	-PRON-	PRP
cord-016293-pyb00pt5	233	19	finds	find	VBZ
cord-016293-pyb00pt5	233	20	a	a	DT
cord-016293-pyb00pt5	233	21	new	new	JJ
cord-016293-pyb00pt5	233	22	disease	disease	NN
cord-016293-pyb00pt5	233	23	gene	gene	NN
cord-016293-pyb00pt5	233	24	.	.	.
cord-016293-pyb00pt5	234	1	One	one	PRP
cord-016293-pyb00pt5	234	2	imagines	imagine	VBZ
cord-016293-pyb00pt5	234	3	that	that	DT
cord-016293-pyb00pt5	234	4	particular	particular	JJ
cord-016293-pyb00pt5	234	5	piece	piece	NN
cord-016293-pyb00pt5	234	6	of	of	IN
cord-016293-pyb00pt5	234	7	really	really	RB
cord-016293-pyb00pt5	234	8	estate	estate	NN
cord-016293-pyb00pt5	234	9	is	be	VBZ
cord-016293-pyb00pt5	234	10	getting	get	VBG
cord-016293-pyb00pt5	234	11	rather	rather	RB
cord-016293-pyb00pt5	234	12	crowded	crowded	JJ
cord-016293-pyb00pt5	234	13	.	.	.
cord-016293-pyb00pt5	235	1	Interestingly	interestingly	RB
cord-016293-pyb00pt5	235	2	it	-PRON-	PRP
cord-016293-pyb00pt5	235	3	was	be	VBD
cord-016293-pyb00pt5	235	4	not	not	RB
cord-016293-pyb00pt5	235	5	these	these	DT
cord-016293-pyb00pt5	235	6	four	four	CD
cord-016293-pyb00pt5	235	7	hundred	hundred	CD
cord-016293-pyb00pt5	235	8	pound	pound	NN
cord-016293-pyb00pt5	235	9	US	US	NNP
cord-016293-pyb00pt5	235	10	gorillas	gorilla	NNS
cord-016293-pyb00pt5	235	11	who	who	WP
cord-016293-pyb00pt5	235	12	proposed	propose	VBD
cord-016293-pyb00pt5	235	13	the	the	DT
cord-016293-pyb00pt5	235	14	eventually	eventually	RB
cord-016293-pyb00pt5	235	15	prescient	prescient	JJ
cord-016293-pyb00pt5	235	16	timeline	timeline	NN
cord-016293-pyb00pt5	235	17	for	for	IN
cord-016293-pyb00pt5	235	18	a	a	DT
cord-016293-pyb00pt5	235	19	working	work	VBG
cord-016293-pyb00pt5	235	20	draft	draft	NN
cord-016293-pyb00pt5	236	1	but	but	CC
cord-016293-pyb00pt5	236	2	two	two	CD
cord-016293-pyb00pt5	236	3	from	from	IN
cord-016293-pyb00pt5	236	4	the	the	DT
cord-016293-pyb00pt5	236	5	old	old	JJ
cord-016293-pyb00pt5	236	6	power	power	NN
cord-016293-pyb00pt5	236	7	base	base	NN
cord-016293-pyb00pt5	236	8	.	.	.
cord-016293-pyb00pt5	237	1	In	in	IN
cord-016293-pyb00pt5	237	2	meetings	meeting	NNS
cord-016293-pyb00pt5	237	3	in	in	IN
cord-016293-pyb00pt5	237	4	the	the	DT
cord-016293-pyb00pt5	237	5	US	US	NNP
cord-016293-pyb00pt5	237	6	in	in	IN
cord-016293-pyb00pt5	237	7	1994	1994	CD
cord-016293-pyb00pt5	237	8	,	,	,
cord-016293-pyb00pt5	237	9	John	John	NNP
cord-016293-pyb00pt5	237	10	Sulston	Sulston	NNP
cord-016293-pyb00pt5	237	11	and	and	CC
cord-016293-pyb00pt5	237	12	Bob	Bob	NNP
cord-016293-pyb00pt5	237	13	Waterston	Waterston	NNP
cord-016293-pyb00pt5	237	14	proposed	propose	VBD
cord-016293-pyb00pt5	237	15	to	to	TO
cord-016293-pyb00pt5	237	16	produce	produce	VB
cord-016293-pyb00pt5	237	17	a	a	DT
cord-016293-pyb00pt5	237	18	'	'	``
cord-016293-pyb00pt5	237	19	draft	draft	NN
cord-016293-pyb00pt5	237	20	'	'	''
cord-016293-pyb00pt5	237	21	sequence	sequence	NN
cord-016293-pyb00pt5	237	22	of	of	IN
cord-016293-pyb00pt5	237	23	the	the	DT
cord-016293-pyb00pt5	237	24	human	human	JJ
cord-016293-pyb00pt5	237	25	genome	genome	NN
cord-016293-pyb00pt5	237	26	by	by	IN
cord-016293-pyb00pt5	237	27	2000	2000	CD
cord-016293-pyb00pt5	237	28	,	,	,
cord-016293-pyb00pt5	237	29	a	a	DT
cord-016293-pyb00pt5	237	30	full	full	JJ
cord-016293-pyb00pt5	237	31	five	five	CD
cord-016293-pyb00pt5	237	32	years	year	NNS
cord-016293-pyb00pt5	237	33	ahead	ahead	RB
cord-016293-pyb00pt5	237	34	of	of	IN
cord-016293-pyb00pt5	237	35	schedule	schedule	NN
cord-016293-pyb00pt5	237	36	.	.	.
cord-016293-pyb00pt5	238	1	While	while	IN
cord-016293-pyb00pt5	238	2	agreed	agree	VBN
cord-016293-pyb00pt5	238	3	by	by	IN
cord-016293-pyb00pt5	238	4	most	most	JJS
cord-016293-pyb00pt5	238	5	to	to	TO
cord-016293-pyb00pt5	238	6	be	be	VB
cord-016293-pyb00pt5	238	7	feasible	feasible	JJ
cord-016293-pyb00pt5	238	8	it	-PRON-	PRP
cord-016293-pyb00pt5	238	9	meant	mean	VBD
cord-016293-pyb00pt5	238	10	a	a	DT
cord-016293-pyb00pt5	238	11	rethinking	rethinking	NN
cord-016293-pyb00pt5	238	12	of	of	IN
cord-016293-pyb00pt5	238	13	strategy	strategy	NN
cord-016293-pyb00pt5	238	14	and	and	CC
cord-016293-pyb00pt5	238	15	involved	involve	VBN
cord-016293-pyb00pt5	238	16	focusing	focus	VBG
cord-016293-pyb00pt5	238	17	resources	resource	NNS
cord-016293-pyb00pt5	238	18	on	on	IN
cord-016293-pyb00pt5	238	19	larger	large	JJR
cord-016293-pyb00pt5	238	20	centers	center	NNS
cord-016293-pyb00pt5	238	21	and	and	CC
cord-016293-pyb00pt5	238	22	emphasizing	emphasize	VBG
cord-016293-pyb00pt5	238	23	sequence	sequence	NN
cord-016293-pyb00pt5	238	24	acquisition	acquisition	NN
cord-016293-pyb00pt5	238	25	.	.	.
cord-016293-pyb00pt5	239	1	Just	just	RB
cord-016293-pyb00pt5	239	2	as	as	IN
cord-016293-pyb00pt5	239	3	important	important	JJ
cord-016293-pyb00pt5	239	4	,	,	,
cord-016293-pyb00pt5	239	5	it	-PRON-	PRP
cord-016293-pyb00pt5	239	6	asserts	assert	VBZ
cord-016293-pyb00pt5	239	7	the	the	DT
cord-016293-pyb00pt5	239	8	value	value	NN
cord-016293-pyb00pt5	239	9	of	of	IN
cord-016293-pyb00pt5	239	10	draft	draft	NN
cord-016293-pyb00pt5	239	11	quality	quality	NN
cord-016293-pyb00pt5	239	12	sequence	sequence	NN
cord-016293-pyb00pt5	239	13	to	to	IN
cord-016293-pyb00pt5	239	14	biomedical	biomedical	JJ
cord-016293-pyb00pt5	239	15	research	research	NN
cord-016293-pyb00pt5	239	16	.	.	.
cord-016293-pyb00pt5	240	1	Discussion	discussion	NN
cord-016293-pyb00pt5	240	2	started	start	VBD
cord-016293-pyb00pt5	240	3	with	with	IN
cord-016293-pyb00pt5	240	4	the	the	DT
cord-016293-pyb00pt5	240	5	British	British	NNP
cord-016293-pyb00pt5	240	6	based	base	VBN
cord-016293-pyb00pt5	240	7	Wellcome	Wellcome	NNP
cord-016293-pyb00pt5	240	8	Trust	Trust	NNP
cord-016293-pyb00pt5	240	9	as	as	IN
cord-016293-pyb00pt5	240	10	possible	possible	JJ
cord-016293-pyb00pt5	240	11	sponsors	sponsor	NNS
cord-016293-pyb00pt5	240	12	(	(	-LRB-
cord-016293-pyb00pt5	240	13	Marshall	Marshall	NNP
cord-016293-pyb00pt5	240	14	E.	E.	NNP
cord-016293-pyb00pt5	240	15	1995	1995	CD
cord-016293-pyb00pt5	240	16	)	)	-RRB-
cord-016293-pyb00pt5	240	17	.	.	.
cord-016293-pyb00pt5	241	1	By	by	IN
cord-016293-pyb00pt5	241	2	1995	1995	CD
cord-016293-pyb00pt5	241	3	a	a	DT
cord-016293-pyb00pt5	241	4	rough	rough	JJ
cord-016293-pyb00pt5	241	5	draft	draft	NN
cord-016293-pyb00pt5	241	6	of	of	IN
cord-016293-pyb00pt5	241	7	the	the	DT
cord-016293-pyb00pt5	241	8	human	human	JJ
cord-016293-pyb00pt5	241	9	genome	genome	NN
cord-016293-pyb00pt5	241	10	map	map	NN
cord-016293-pyb00pt5	241	11	was	be	VBD
cord-016293-pyb00pt5	241	12	produced	produce	VBN
cord-016293-pyb00pt5	241	13	showing	show	VBG
cord-016293-pyb00pt5	241	14	the	the	DT
cord-016293-pyb00pt5	241	15	locations	location	NNS
cord-016293-pyb00pt5	241	16	of	of	IN
cord-016293-pyb00pt5	241	17	more	more	JJR
cord-016293-pyb00pt5	241	18	than	than	IN
cord-016293-pyb00pt5	241	19	30,000	30,000	CD
cord-016293-pyb00pt5	241	20	genes	gene	NNS
cord-016293-pyb00pt5	241	21	.	.	.
cord-016293-pyb00pt5	242	1	The	the	DT
cord-016293-pyb00pt5	242	2	map	map	NN
cord-016293-pyb00pt5	242	3	was	be	VBD
cord-016293-pyb00pt5	242	4	produced	produce	VBN
cord-016293-pyb00pt5	242	5	using	use	VBG
cord-016293-pyb00pt5	242	6	yeast	yeast	NN
cord-016293-pyb00pt5	242	7	artificial	artificial	JJ
cord-016293-pyb00pt5	242	8	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	242	9	and	and	CC
cord-016293-pyb00pt5	242	10	some	some	DT
cord-016293-pyb00pt5	242	11	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	242	12	-notably	-notably	RB
cord-016293-pyb00pt5	243	1	the	the	DT
cord-016293-pyb00pt5	243	2	littlest	little	JJS
cord-016293-pyb00pt5	243	3	22	22	CD
cord-016293-pyb00pt5	243	4	-were	-were	RB
cord-016293-pyb00pt5	243	5	mapped	map	VBN
cord-016293-pyb00pt5	243	6	in	in	IN
cord-016293-pyb00pt5	243	7	finer	fine	JJR
cord-016293-pyb00pt5	243	8	detail	detail	NN
cord-016293-pyb00pt5	243	9	.	.	.
cord-016293-pyb00pt5	244	1	These	these	DT
cord-016293-pyb00pt5	244	2	maps	map	NNS
cord-016293-pyb00pt5	244	3	marked	mark	VBD
cord-016293-pyb00pt5	244	4	an	an	DT
cord-016293-pyb00pt5	244	5	important	important	JJ
cord-016293-pyb00pt5	244	6	step	step	NN
cord-016293-pyb00pt5	244	7	toward	toward	IN
cord-016293-pyb00pt5	244	8	clone	clone	NN
cord-016293-pyb00pt5	244	9	-	-	HYPH
cord-016293-pyb00pt5	244	10	based	base	VBN
cord-016293-pyb00pt5	244	11	sequencing	sequencing	NN
cord-016293-pyb00pt5	244	12	.	.	.
cord-016293-pyb00pt5	245	1	The	the	DT
cord-016293-pyb00pt5	245	2	importance	importance	NN
cord-016293-pyb00pt5	245	3	was	be	VBD
cord-016293-pyb00pt5	245	4	illustrated	illustrate	VBN
cord-016293-pyb00pt5	245	5	in	in	IN
cord-016293-pyb00pt5	245	6	the	the	DT
cord-016293-pyb00pt5	245	7	devotion	devotion	NN
cord-016293-pyb00pt5	245	8	of	of	IN
cord-016293-pyb00pt5	245	9	an	an	DT
cord-016293-pyb00pt5	245	10	entire	entire	JJ
cord-016293-pyb00pt5	245	11	edition	edition	NN
cord-016293-pyb00pt5	245	12	of	of	IN
cord-016293-pyb00pt5	245	13	the	the	DT
cord-016293-pyb00pt5	245	14	journal	journal	NN
cord-016293-pyb00pt5	245	15	Nature	Nature	NNP
cord-016293-pyb00pt5	245	16	to	to	IN
cord-016293-pyb00pt5	245	17	the	the	DT
cord-016293-pyb00pt5	245	18	subject	subject	NN
cord-016293-pyb00pt5	245	19	.	.	.
cord-016293-pyb00pt5	246	1	(	(	-LRB-
cord-016293-pyb00pt5	246	2	Nature	nature	NN
cord-016293-pyb00pt5	246	3	377	377	CD
cord-016293-pyb00pt5	246	4	:	:	:
cord-016293-pyb00pt5	246	5	175	175	CD
cord-016293-pyb00pt5	246	6	-	-	SYM
cord-016293-pyb00pt5	246	7	379	379	CD
cord-016293-pyb00pt5	246	8	1995	1995	CD
cord-016293-pyb00pt5	246	9	)	)	-RRB-
cord-016293-pyb00pt5	247	1	The	the	DT
cord-016293-pyb00pt5	247	2	duel	duel	NN
cord-016293-pyb00pt5	247	3	between	between	IN
cord-016293-pyb00pt5	247	4	the	the	DT
cord-016293-pyb00pt5	247	5	public	public	JJ
cord-016293-pyb00pt5	247	6	and	and	CC
cord-016293-pyb00pt5	247	7	private	private	JJ
cord-016293-pyb00pt5	247	8	face	face	NN
cord-016293-pyb00pt5	247	9	of	of	IN
cord-016293-pyb00pt5	247	10	the	the	DT
cord-016293-pyb00pt5	247	11	HGP	hgp	NN
cord-016293-pyb00pt5	247	12	progressed	progress	VBD
cord-016293-pyb00pt5	247	13	at	at	IN
cord-016293-pyb00pt5	247	14	a	a	DT
cord-016293-pyb00pt5	247	15	pace	pace	NN
cord-016293-pyb00pt5	247	16	over	over	IN
cord-016293-pyb00pt5	247	17	the	the	DT
cord-016293-pyb00pt5	247	18	next	next	JJ
cord-016293-pyb00pt5	247	19	five	five	CD
cord-016293-pyb00pt5	247	20	years	year	NNS
cord-016293-pyb00pt5	247	21	.	.	.
cord-016293-pyb00pt5	248	1	Following	follow	VBG
cord-016293-pyb00pt5	248	2	release	release	NN
cord-016293-pyb00pt5	248	3	of	of	IN
cord-016293-pyb00pt5	248	4	the	the	DT
cord-016293-pyb00pt5	248	5	mapping	mapping	NN
cord-016293-pyb00pt5	248	6	data	datum	NNS
cord-016293-pyb00pt5	248	7	some	some	DT
cord-016293-pyb00pt5	248	8	level	level	NN
cord-016293-pyb00pt5	248	9	of	of	IN
cord-016293-pyb00pt5	248	10	international	international	JJ
cord-016293-pyb00pt5	248	11	agreement	agreement	NN
cord-016293-pyb00pt5	248	12	was	be	VBD
cord-016293-pyb00pt5	248	13	decided	decide	VBN
cord-016293-pyb00pt5	248	14	on	on	IN
cord-016293-pyb00pt5	248	15	sequence	sequence	NN
cord-016293-pyb00pt5	248	16	data	data	NN
cord-016293-pyb00pt5	248	17	release	release	NN
cord-016293-pyb00pt5	248	18	and	and	CC
cord-016293-pyb00pt5	248	19	databases	database	NNS
cord-016293-pyb00pt5	248	20	.	.	.
cord-016293-pyb00pt5	249	1	They	-PRON-	PRP
cord-016293-pyb00pt5	249	2	agreed	agree	VBD
cord-016293-pyb00pt5	249	3	on	on	IN
cord-016293-pyb00pt5	249	4	the	the	DT
cord-016293-pyb00pt5	249	5	release	release	NN
cord-016293-pyb00pt5	249	6	of	of	IN
cord-016293-pyb00pt5	249	7	sequence	sequence	NN
cord-016293-pyb00pt5	249	8	data	datum	NNS
cord-016293-pyb00pt5	249	9	,	,	,
cord-016293-pyb00pt5	249	10	specifically	specifically	RB
cord-016293-pyb00pt5	249	11	,	,	,
cord-016293-pyb00pt5	249	12	that	that	IN
cord-016293-pyb00pt5	249	13	Primary	Primary	NNP
cord-016293-pyb00pt5	249	14	Genomic	Genomic	NNP
cord-016293-pyb00pt5	249	15	Sequence	sequence	NN
cord-016293-pyb00pt5	249	16	should	should	MD
cord-016293-pyb00pt5	249	17	be	be	VB
cord-016293-pyb00pt5	249	18	in	in	IN
cord-016293-pyb00pt5	249	19	the	the	DT
cord-016293-pyb00pt5	249	20	Public	Public	NNP
cord-016293-pyb00pt5	249	21	Domain	Domain	NNP
cord-016293-pyb00pt5	249	22	to	to	TO
cord-016293-pyb00pt5	249	23	encourage	encourage	VB
cord-016293-pyb00pt5	249	24	research	research	NN
cord-016293-pyb00pt5	249	25	and	and	CC
cord-016293-pyb00pt5	249	26	development	development	NN
cord-016293-pyb00pt5	249	27	to	to	TO
cord-016293-pyb00pt5	249	28	maximize	maximize	VB
cord-016293-pyb00pt5	249	29	its	-PRON-	PRP$
cord-016293-pyb00pt5	249	30	benefit	benefit	NN
cord-016293-pyb00pt5	249	31	to	to	IN
cord-016293-pyb00pt5	249	32	society	society	NN
cord-016293-pyb00pt5	249	33	.	.	.
cord-016293-pyb00pt5	250	1	Also	also	RB
cord-016293-pyb00pt5	250	2	that	that	IN
cord-016293-pyb00pt5	250	3	it	-PRON-	PRP
cord-016293-pyb00pt5	250	4	be	be	VB
cord-016293-pyb00pt5	250	5	rapidly	rapidly	RB
cord-016293-pyb00pt5	250	6	released	release	VBN
cord-016293-pyb00pt5	250	7	on	on	IN
cord-016293-pyb00pt5	250	8	a	a	DT
cord-016293-pyb00pt5	250	9	daily	daily	JJ
cord-016293-pyb00pt5	250	10	basis	basis	NN
cord-016293-pyb00pt5	250	11	with	with	IN
cord-016293-pyb00pt5	250	12	assemblies	assembly	NNS
cord-016293-pyb00pt5	250	13	of	of	IN
cord-016293-pyb00pt5	250	14	greater	great	JJR
cord-016293-pyb00pt5	250	15	than	than	IN
cord-016293-pyb00pt5	250	16	1	1	CD
cord-016293-pyb00pt5	250	17	Kb	Kb	NNP
cord-016293-pyb00pt5	250	18	and	and	CC
cord-016293-pyb00pt5	250	19	that	that	IN
cord-016293-pyb00pt5	250	20	the	the	DT
cord-016293-pyb00pt5	250	21	finished	finished	JJ
cord-016293-pyb00pt5	250	22	annotated	annotated	JJ
cord-016293-pyb00pt5	250	23	sequence	sequence	NN
cord-016293-pyb00pt5	250	24	should	should	MD
cord-016293-pyb00pt5	250	25	be	be	VB
cord-016293-pyb00pt5	250	26	submitted	submit	VBN
cord-016293-pyb00pt5	250	27	immediately	immediately	RB
cord-016293-pyb00pt5	250	28	to	to	IN
cord-016293-pyb00pt5	250	29	the	the	DT
cord-016293-pyb00pt5	250	30	public	public	JJ
cord-016293-pyb00pt5	250	31	databases	database	NNS
cord-016293-pyb00pt5	250	32	.	.	.
cord-016293-pyb00pt5	251	1	In	in	IN
cord-016293-pyb00pt5	251	2	1996	1996	CD
cord-016293-pyb00pt5	251	3	an	an	DT
cord-016293-pyb00pt5	251	4	international	international	JJ
cord-016293-pyb00pt5	251	5	consortium	consortium	NN
cord-016293-pyb00pt5	251	6	completed	complete	VBD
cord-016293-pyb00pt5	251	7	the	the	DT
cord-016293-pyb00pt5	251	8	sequence	sequence	NN
cord-016293-pyb00pt5	251	9	of	of	IN
cord-016293-pyb00pt5	251	10	the	the	DT
cord-016293-pyb00pt5	251	11	genome	genome	NN
cord-016293-pyb00pt5	251	12	of	of	IN
cord-016293-pyb00pt5	251	13	the	the	DT
cord-016293-pyb00pt5	251	14	workhorse	workhorse	JJ
cord-016293-pyb00pt5	251	15	yeast	yeast	NN
cord-016293-pyb00pt5	251	16	Saccharomyces	Saccharomyces	NNP
cord-016293-pyb00pt5	251	17	cerevisiae	cerevisiae	NNS
cord-016293-pyb00pt5	251	18	.	.	.
cord-016293-pyb00pt5	252	1	Data	datum	NNS
cord-016293-pyb00pt5	252	2	had	have	VBD
cord-016293-pyb00pt5	252	3	been	be	VBN
cord-016293-pyb00pt5	252	4	released	release	VBN
cord-016293-pyb00pt5	252	5	as	as	IN
cord-016293-pyb00pt5	252	6	the	the	DT
cord-016293-pyb00pt5	252	7	individual	individual	JJ
cord-016293-pyb00pt5	252	8	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	252	9	were	be	VBD
cord-016293-pyb00pt5	252	10	completed	complete	VBN
cord-016293-pyb00pt5	252	11	.	.	.
cord-016293-pyb00pt5	253	1	The	the	DT
cord-016293-pyb00pt5	253	2	Saccharomyces	Saccharomyces	NNP
cord-016293-pyb00pt5	253	3	Genome	Genome	NNP
cord-016293-pyb00pt5	253	4	Database	Database	NNP
cord-016293-pyb00pt5	253	5	(	(	-LRB-
cord-016293-pyb00pt5	253	6	SGD	SGD	NNP
cord-016293-pyb00pt5	253	7	)	)	-RRB-
cord-016293-pyb00pt5	253	8	was	be	VBD
cord-016293-pyb00pt5	253	9	created	create	VBN
cord-016293-pyb00pt5	253	10	to	to	TO
cord-016293-pyb00pt5	253	11	curate	curate	VB
cord-016293-pyb00pt5	253	12	this	this	DT
cord-016293-pyb00pt5	253	13	information	information	NN
cord-016293-pyb00pt5	253	14	.	.	.
cord-016293-pyb00pt5	254	1	The	the	DT
cord-016293-pyb00pt5	254	2	project	project	NN
cord-016293-pyb00pt5	254	3	collects	collect	VBZ
cord-016293-pyb00pt5	254	4	information	information	NN
cord-016293-pyb00pt5	254	5	and	and	CC
cord-016293-pyb00pt5	254	6	maintains	maintain	VBZ
cord-016293-pyb00pt5	254	7	a	a	DT
cord-016293-pyb00pt5	254	8	database	database	NN
cord-016293-pyb00pt5	254	9	of	of	IN
cord-016293-pyb00pt5	254	10	the	the	DT
cord-016293-pyb00pt5	254	11	molecular	molecular	JJ
cord-016293-pyb00pt5	254	12	biology	biology	NN
cord-016293-pyb00pt5	254	13	of	of	IN
cord-016293-pyb00pt5	254	14	S.	S.	NNP
cord-016293-pyb00pt5	254	15	cerevisiae	cerevisiae	NNS
cord-016293-pyb00pt5	254	16	.	.	.
cord-016293-pyb00pt5	255	1	This	this	DT
cord-016293-pyb00pt5	255	2	database	database	NN
cord-016293-pyb00pt5	255	3	includes	include	VBZ
cord-016293-pyb00pt5	255	4	a	a	DT
cord-016293-pyb00pt5	255	5	variety	variety	NN
cord-016293-pyb00pt5	255	6	of	of	IN
cord-016293-pyb00pt5	255	7	genomic	genomic	JJ
cord-016293-pyb00pt5	255	8	and	and	CC
cord-016293-pyb00pt5	255	9	biological	biological	JJ
cord-016293-pyb00pt5	255	10	information	information	NN
cord-016293-pyb00pt5	255	11	and	and	CC
cord-016293-pyb00pt5	255	12	is	be	VBZ
cord-016293-pyb00pt5	255	13	maintained	maintain	VBN
cord-016293-pyb00pt5	255	14	and	and	CC
cord-016293-pyb00pt5	255	15	updated	update	VBN
cord-016293-pyb00pt5	255	16	by	by	IN
cord-016293-pyb00pt5	255	17	SGD	SGD	NNP
cord-016293-pyb00pt5	255	18	curators	curator	NNS
cord-016293-pyb00pt5	255	19	.	.	.
cord-016293-pyb00pt5	256	1	The	the	DT
cord-016293-pyb00pt5	256	2	SGD	SGD	NNP
cord-016293-pyb00pt5	256	3	also	also	RB
cord-016293-pyb00pt5	256	4	maintains	maintain	VBZ
cord-016293-pyb00pt5	256	5	the	the	DT
cord-016293-pyb00pt5	256	6	S.	S.	NNP
cord-016293-pyb00pt5	256	7	cerevisiae	cerevisiae	NN
cord-016293-pyb00pt5	256	8	Gene	Gene	NNP
cord-016293-pyb00pt5	256	9	Name	Name	NNP
cord-016293-pyb00pt5	256	10	Registry	Registry	NNP
cord-016293-pyb00pt5	256	11	,	,	,
cord-016293-pyb00pt5	256	12	a	a	DT
cord-016293-pyb00pt5	256	13	complete	complete	JJ
cord-016293-pyb00pt5	256	14	list	list	NN
cord-016293-pyb00pt5	256	15	of	of	IN
cord-016293-pyb00pt5	256	16	all	all	DT
cord-016293-pyb00pt5	256	17	gene	gene	NN
cord-016293-pyb00pt5	256	18	names	name	NNS
cord-016293-pyb00pt5	256	19	used	use	VBN
cord-016293-pyb00pt5	256	20	in	in	IN
cord-016293-pyb00pt5	256	21	S.	S.	NNP
cord-016293-pyb00pt5	256	22	cerevisiae	cerevisiae	NNS
cord-016293-pyb00pt5	256	23	.	.	.
cord-016293-pyb00pt5	257	1	In	in	IN
cord-016293-pyb00pt5	257	2	1997	1997	CD
cord-016293-pyb00pt5	257	3	a	a	DT
cord-016293-pyb00pt5	257	4	new	new	JJ
cord-016293-pyb00pt5	257	5	more	more	RBR
cord-016293-pyb00pt5	257	6	powerful	powerful	JJ
cord-016293-pyb00pt5	257	7	diagnostic	diagnostic	JJ
cord-016293-pyb00pt5	257	8	tool	tool	NN
cord-016293-pyb00pt5	257	9	termed	term	VBN
cord-016293-pyb00pt5	257	10	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	257	11	(	(	-LRB-
cord-016293-pyb00pt5	257	12	Single	Single	NNP
cord-016293-pyb00pt5	257	13	Nucleotide	Nucleotide	NNP
cord-016293-pyb00pt5	257	14	Polymorphisms	Polymorphisms	NNPS
cord-016293-pyb00pt5	257	15	)	)	-RRB-
cord-016293-pyb00pt5	257	16	was	be	VBD
cord-016293-pyb00pt5	257	17	developed	develop	VBN
cord-016293-pyb00pt5	257	18	.	.	.
cord-016293-pyb00pt5	258	1	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	258	2	are	be	VBP
cord-016293-pyb00pt5	258	3	changes	change	NNS
cord-016293-pyb00pt5	258	4	in	in	IN
cord-016293-pyb00pt5	258	5	single	single	JJ
cord-016293-pyb00pt5	258	6	letters	letter	NNS
cord-016293-pyb00pt5	258	7	in	in	IN
cord-016293-pyb00pt5	258	8	our	-PRON-	PRP$
cord-016293-pyb00pt5	258	9	DNA	dna	NN
cord-016293-pyb00pt5	258	10	code	code	NN
cord-016293-pyb00pt5	258	11	that	that	WDT
cord-016293-pyb00pt5	258	12	can	can	MD
cord-016293-pyb00pt5	258	13	act	act	VB
cord-016293-pyb00pt5	258	14	as	as	IN
cord-016293-pyb00pt5	258	15	markers	marker	NNS
cord-016293-pyb00pt5	258	16	in	in	IN
cord-016293-pyb00pt5	258	17	the	the	DT
cord-016293-pyb00pt5	258	18	DNA	dna	NN
cord-016293-pyb00pt5	258	19	landscape	landscape	NN
cord-016293-pyb00pt5	258	20	.	.	.
cord-016293-pyb00pt5	259	1	Some	some	DT
cord-016293-pyb00pt5	259	2	SNPs	snp	NNS
cord-016293-pyb00pt5	259	3	are	be	VBP
cord-016293-pyb00pt5	259	4	associated	associate	VBN
cord-016293-pyb00pt5	259	5	closely	closely	RB
cord-016293-pyb00pt5	259	6	with	with	IN
cord-016293-pyb00pt5	259	7	susceptibility	susceptibility	NN
cord-016293-pyb00pt5	259	8	to	to	IN
cord-016293-pyb00pt5	259	9	genetic	genetic	JJ
cord-016293-pyb00pt5	259	10	disease	disease	NN
cord-016293-pyb00pt5	259	11	,	,	,
cord-016293-pyb00pt5	259	12	our	-PRON-	PRP$
cord-016293-pyb00pt5	259	13	response	response	NN
cord-016293-pyb00pt5	259	14	to	to	IN
cord-016293-pyb00pt5	259	15	drugs	drug	NNS
cord-016293-pyb00pt5	259	16	or	or	CC
cord-016293-pyb00pt5	259	17	our	-PRON-	PRP$
cord-016293-pyb00pt5	259	18	ability	ability	NN
cord-016293-pyb00pt5	259	19	to	to	TO
cord-016293-pyb00pt5	259	20	remove	remove	VB
cord-016293-pyb00pt5	259	21	toxins	toxin	NNS
cord-016293-pyb00pt5	259	22	.	.	.
cord-016293-pyb00pt5	260	1	The	the	DT
cord-016293-pyb00pt5	260	2	SNP	SNP	NNP
cord-016293-pyb00pt5	260	3	Consortium	Consortium	NNP
cord-016293-pyb00pt5	260	4	although	although	IN
cord-016293-pyb00pt5	260	5	designated	designate	VBD
cord-016293-pyb00pt5	260	6	a	a	DT
cord-016293-pyb00pt5	260	7	limited	limited	JJ
cord-016293-pyb00pt5	260	8	company	company	NN
cord-016293-pyb00pt5	260	9	is	be	VBZ
cord-016293-pyb00pt5	260	10	a	a	DT
cord-016293-pyb00pt5	260	11	nonprofit	nonprofit	JJ
cord-016293-pyb00pt5	260	12	foundation	foundation	NN
cord-016293-pyb00pt5	260	13	organized	organize	VBN
cord-016293-pyb00pt5	260	14	for	for	IN
cord-016293-pyb00pt5	260	15	the	the	DT
cord-016293-pyb00pt5	260	16	purpose	purpose	NN
cord-016293-pyb00pt5	260	17	of	of	IN
cord-016293-pyb00pt5	260	18	providing	provide	VBG
cord-016293-pyb00pt5	260	19	public	public	JJ
cord-016293-pyb00pt5	260	20	genomic	genomic	JJ
cord-016293-pyb00pt5	260	21	data	datum	NNS
cord-016293-pyb00pt5	260	22	.	.	.
cord-016293-pyb00pt5	261	1	It	-PRON-	PRP
cord-016293-pyb00pt5	261	2	is	be	VBZ
cord-016293-pyb00pt5	261	3	a	a	DT
cord-016293-pyb00pt5	261	4	collaborative	collaborative	JJ
cord-016293-pyb00pt5	261	5	effort	effort	NN
cord-016293-pyb00pt5	261	6	between	between	IN
cord-016293-pyb00pt5	261	7	pharmaceutical	pharmaceutical	JJ
cord-016293-pyb00pt5	261	8	companies	company	NNS
cord-016293-pyb00pt5	261	9	and	and	CC
cord-016293-pyb00pt5	261	10	the	the	DT
cord-016293-pyb00pt5	261	11	Wellcome	Wellcome	NNP
cord-016293-pyb00pt5	261	12	Trust	Trust	NNP
cord-016293-pyb00pt5	261	13	with	with	IN
cord-016293-pyb00pt5	261	14	the	the	DT
cord-016293-pyb00pt5	261	15	idea	idea	NN
cord-016293-pyb00pt5	261	16	of	of	IN
cord-016293-pyb00pt5	261	17	making	make	VBG
cord-016293-pyb00pt5	261	18	available	available	JJ
cord-016293-pyb00pt5	261	19	widely	widely	RB
cord-016293-pyb00pt5	261	20	accepted	accept	VBN
cord-016293-pyb00pt5	261	21	,	,	,
cord-016293-pyb00pt5	261	22	high	high	JJ
cord-016293-pyb00pt5	261	23	-	-	HYPH
cord-016293-pyb00pt5	261	24	quality	quality	NN
cord-016293-pyb00pt5	261	25	,	,	,
cord-016293-pyb00pt5	261	26	extensive	extensive	JJ
cord-016293-pyb00pt5	261	27	,	,	,
cord-016293-pyb00pt5	261	28	and	and	CC
cord-016293-pyb00pt5	261	29	publicly	publicly	RB
cord-016293-pyb00pt5	261	30	accessible	accessible	JJ
cord-016293-pyb00pt5	261	31	SNP	SNP	NNP
cord-016293-pyb00pt5	261	32	map	map	NN
cord-016293-pyb00pt5	261	33	.	.	.
cord-016293-pyb00pt5	262	1	Its	-PRON-	PRP$
cord-016293-pyb00pt5	262	2	mission	mission	NN
cord-016293-pyb00pt5	262	3	was	be	VBD
cord-016293-pyb00pt5	262	4	to	to	TO
cord-016293-pyb00pt5	262	5	develop	develop	VB
cord-016293-pyb00pt5	262	6	up	up	IN
cord-016293-pyb00pt5	262	7	to	to	TO
cord-016293-pyb00pt5	262	8	300,000	300,000	CD
cord-016293-pyb00pt5	262	9	SNPs	snp	NNS
cord-016293-pyb00pt5	262	10	distributed	distribute	VBN
cord-016293-pyb00pt5	262	11	evenly	evenly	RB
cord-016293-pyb00pt5	262	12	throughout	throughout	IN
cord-016293-pyb00pt5	262	13	the	the	DT
cord-016293-pyb00pt5	262	14	human	human	JJ
cord-016293-pyb00pt5	262	15	genome	genome	NN
cord-016293-pyb00pt5	262	16	and	and	CC
cord-016293-pyb00pt5	262	17	to	to	TO
cord-016293-pyb00pt5	262	18	make	make	VB
cord-016293-pyb00pt5	262	19	the	the	DT
cord-016293-pyb00pt5	262	20	information	information	NN
cord-016293-pyb00pt5	262	21	related	relate	VBN
cord-016293-pyb00pt5	262	22	to	to	IN
cord-016293-pyb00pt5	262	23	these	these	DT
cord-016293-pyb00pt5	262	24	SNPs	snp	NNS
cord-016293-pyb00pt5	262	25	available	available	JJ
cord-016293-pyb00pt5	262	26	to	to	IN
cord-016293-pyb00pt5	262	27	the	the	DT
cord-016293-pyb00pt5	262	28	public	public	NN
cord-016293-pyb00pt5	262	29	without	without	IN
cord-016293-pyb00pt5	262	30	intellectual	intellectual	JJ
cord-016293-pyb00pt5	262	31	property	property	NN
cord-016293-pyb00pt5	262	32	restrictions	restriction	NNS
cord-016293-pyb00pt5	262	33	.	.	.
cord-016293-pyb00pt5	263	1	The	the	DT
cord-016293-pyb00pt5	263	2	project	project	NN
cord-016293-pyb00pt5	263	3	started	start	VBD
cord-016293-pyb00pt5	263	4	in	in	IN
cord-016293-pyb00pt5	263	5	April	April	NNP
cord-016293-pyb00pt5	263	6	1999	1999	CD
cord-016293-pyb00pt5	263	7	and	and	CC
cord-016293-pyb00pt5	263	8	was	be	VBD
cord-016293-pyb00pt5	263	9	anticipated	anticipate	VBN
cord-016293-pyb00pt5	263	10	to	to	TO
cord-016293-pyb00pt5	263	11	continue	continue	VB
cord-016293-pyb00pt5	263	12	until	until	IN
cord-016293-pyb00pt5	263	13	the	the	DT
cord-016293-pyb00pt5	263	14	end	end	NN
cord-016293-pyb00pt5	263	15	of	of	IN
cord-016293-pyb00pt5	263	16	2001	2001	CD
cord-016293-pyb00pt5	263	17	.	.	.
cord-016293-pyb00pt5	264	1	In	in	IN
cord-016293-pyb00pt5	264	2	the	the	DT
cord-016293-pyb00pt5	264	3	end	end	NN
cord-016293-pyb00pt5	264	4	,	,	,
cord-016293-pyb00pt5	264	5	many	many	JJ
cord-016293-pyb00pt5	264	6	more	more	JJR
cord-016293-pyb00pt5	264	7	SNPs	snp	NNS
cord-016293-pyb00pt5	264	8	,	,	,
cord-016293-pyb00pt5	264	9	about	about	RB
cord-016293-pyb00pt5	264	10	1.5	1.5	CD
cord-016293-pyb00pt5	264	11	million	million	CD
cord-016293-pyb00pt5	264	12	total	total	NN
cord-016293-pyb00pt5	264	13	,	,	,
cord-016293-pyb00pt5	264	14	were	be	VBD
cord-016293-pyb00pt5	264	15	discovered	discover	VBN
cord-016293-pyb00pt5	264	16	than	than	IN
cord-016293-pyb00pt5	264	17	was	be	VBD
cord-016293-pyb00pt5	264	18	originally	originally	RB
cord-016293-pyb00pt5	264	19	planned	plan	VBN
cord-016293-pyb00pt5	264	20	.	.	.
cord-016293-pyb00pt5	265	1	By	by	IN
cord-016293-pyb00pt5	265	2	1998	1998	CD
cord-016293-pyb00pt5	265	3	the	the	DT
cord-016293-pyb00pt5	265	4	complete	complete	JJ
cord-016293-pyb00pt5	265	5	genome	genome	NN
cord-016293-pyb00pt5	265	6	sequence	sequence	NN
cord-016293-pyb00pt5	265	7	of	of	IN
cord-016293-pyb00pt5	265	8	Mycobacterium	Mycobacterium	NNP
cord-016293-pyb00pt5	265	9	tuberculosis	tuberculosis	NN
cord-016293-pyb00pt5	265	10	was	be	VBD
cord-016293-pyb00pt5	265	11	published	publish	VBN
cord-016293-pyb00pt5	265	12	by	by	IN
cord-016293-pyb00pt5	265	13	teams	team	NNS
cord-016293-pyb00pt5	265	14	from	from	IN
cord-016293-pyb00pt5	265	15	the	the	DT
cord-016293-pyb00pt5	265	16	UK	UK	NNP
cord-016293-pyb00pt5	265	17	,	,	,
cord-016293-pyb00pt5	265	18	France	France	NNP
cord-016293-pyb00pt5	265	19	,	,	,
cord-016293-pyb00pt5	265	20	US	US	NNP
cord-016293-pyb00pt5	265	21	and	and	CC
cord-016293-pyb00pt5	265	22	Denmark	Denmark	NNP
cord-016293-pyb00pt5	265	23	in	in	IN
cord-016293-pyb00pt5	265	24	June	June	NNP
cord-016293-pyb00pt5	265	25	1998	1998	CD
cord-016293-pyb00pt5	265	26	.	.	.
cord-016293-pyb00pt5	266	1	The	the	DT
cord-016293-pyb00pt5	266	2	ABI	ABI	NNP
cord-016293-pyb00pt5	266	3	Prism	Prism	NNP
cord-016293-pyb00pt5	266	4	3700	3700	CD
cord-016293-pyb00pt5	266	5	sequencing	sequencing	NN
cord-016293-pyb00pt5	266	6	machine	machine	NN
cord-016293-pyb00pt5	266	7	,	,	,
cord-016293-pyb00pt5	266	8	a	a	DT
cord-016293-pyb00pt5	266	9	capillary	capillary	NN
cord-016293-pyb00pt5	266	10	-	-	HYPH
cord-016293-pyb00pt5	266	11	based	base	VBN
cord-016293-pyb00pt5	266	12	machine	machine	NN
cord-016293-pyb00pt5	266	13	designed	design	VBN
cord-016293-pyb00pt5	266	14	to	to	TO
cord-016293-pyb00pt5	266	15	run	run	VB
cord-016293-pyb00pt5	266	16	about	about	RB
cord-016293-pyb00pt5	266	17	eight	eight	CD
cord-016293-pyb00pt5	266	18	sets	set	NNS
cord-016293-pyb00pt5	266	19	of	of	IN
cord-016293-pyb00pt5	266	20	96	96	CD
cord-016293-pyb00pt5	266	21	sequence	sequence	NN
cord-016293-pyb00pt5	266	22	reactions	reaction	NNS
cord-016293-pyb00pt5	266	23	per	per	IN
cord-016293-pyb00pt5	266	24	day	day	NN
cord-016293-pyb00pt5	266	25	also	also	RB
cord-016293-pyb00pt5	266	26	reached	reach	VBD
cord-016293-pyb00pt5	266	27	the	the	DT
cord-016293-pyb00pt5	266	28	market	market	NN
cord-016293-pyb00pt5	266	29	that	that	DT
cord-016293-pyb00pt5	266	30	year	year	NN
cord-016293-pyb00pt5	266	31	.	.	.
cord-016293-pyb00pt5	267	1	That	that	DT
cord-016293-pyb00pt5	267	2	same	same	JJ
cord-016293-pyb00pt5	267	3	year	year	NN
cord-016293-pyb00pt5	267	4	the	the	DT
cord-016293-pyb00pt5	267	5	genome	genome	NN
cord-016293-pyb00pt5	267	6	sequence	sequence	NN
cord-016293-pyb00pt5	267	7	of	of	IN
cord-016293-pyb00pt5	267	8	the	the	DT
cord-016293-pyb00pt5	267	9	first	first	JJ
cord-016293-pyb00pt5	267	10	multicellular	multicellular	JJ
cord-016293-pyb00pt5	267	11	organism	organism	NN
cord-016293-pyb00pt5	267	12	,	,	,
cord-016293-pyb00pt5	267	13	C.	C.	NNP
cord-016293-pyb00pt5	267	14	elegans	elegan	NNS
cord-016293-pyb00pt5	267	15	was	be	VBD
cord-016293-pyb00pt5	267	16	completed	complete	VBN
cord-016293-pyb00pt5	267	17	.	.	.
cord-016293-pyb00pt5	268	1	C.	C.	NNP
cord-016293-pyb00pt5	268	2	elegans	elegan	NNS
cord-016293-pyb00pt5	268	3	has	have	VBZ
cord-016293-pyb00pt5	268	4	a	a	DT
cord-016293-pyb00pt5	268	5	genome	genome	NN
cord-016293-pyb00pt5	268	6	of	of	IN
cord-016293-pyb00pt5	268	7	about	about	RB
cord-016293-pyb00pt5	268	8	100	100	CD
cord-016293-pyb00pt5	268	9	Mb	Mb	NNS
cord-016293-pyb00pt5	268	10	and	and	CC
cord-016293-pyb00pt5	268	11	,	,	,
cord-016293-pyb00pt5	268	12	as	as	IN
cord-016293-pyb00pt5	268	13	noted	note	VBN
cord-016293-pyb00pt5	268	14	,	,	,
cord-016293-pyb00pt5	268	15	is	be	VBZ
cord-016293-pyb00pt5	268	16	a	a	DT
cord-016293-pyb00pt5	268	17	primitive	primitive	JJ
cord-016293-pyb00pt5	268	18	animal	animal	NN
cord-016293-pyb00pt5	268	19	model	model	NN
cord-016293-pyb00pt5	268	20	organism	organism	NN
cord-016293-pyb00pt5	268	21	used	use	VBN
cord-016293-pyb00pt5	268	22	in	in	IN
cord-016293-pyb00pt5	268	23	a	a	DT
cord-016293-pyb00pt5	268	24	range	range	NN
cord-016293-pyb00pt5	268	25	of	of	IN
cord-016293-pyb00pt5	268	26	biological	biological	JJ
cord-016293-pyb00pt5	268	27	disciplines	discipline	NNS
cord-016293-pyb00pt5	268	28	.	.	.
cord-016293-pyb00pt5	269	1	By	by	IN
cord-016293-pyb00pt5	269	2	November	November	NNP
cord-016293-pyb00pt5	269	3	1999	1999	CD
cord-016293-pyb00pt5	269	4	the	the	DT
cord-016293-pyb00pt5	269	5	human	human	JJ
cord-016293-pyb00pt5	269	6	genome	genome	NN
cord-016293-pyb00pt5	269	7	draft	draft	NN
cord-016293-pyb00pt5	269	8	sequence	sequence	NN
cord-016293-pyb00pt5	269	9	reached	reach	VBD
cord-016293-pyb00pt5	269	10	1000	1000	CD
cord-016293-pyb00pt5	269	11	Mb	Mb	NNS
cord-016293-pyb00pt5	269	12	and	and	CC
cord-016293-pyb00pt5	269	13	the	the	DT
cord-016293-pyb00pt5	269	14	first	first	JJ
cord-016293-pyb00pt5	269	15	complete	complete	JJ
cord-016293-pyb00pt5	269	16	human	human	JJ
cord-016293-pyb00pt5	269	17	chromosome	chromosome	NN
cord-016293-pyb00pt5	269	18	was	be	VBD
cord-016293-pyb00pt5	269	19	sequenced	sequence	VBN
cord-016293-pyb00pt5	269	20	-this	-this	NN
cord-016293-pyb00pt5	269	21	first	first	RB
cord-016293-pyb00pt5	269	22	was	be	VBD
cord-016293-pyb00pt5	269	23	reached	reach	VBN
cord-016293-pyb00pt5	269	24	on	on	IN
cord-016293-pyb00pt5	269	25	the	the	DT
cord-016293-pyb00pt5	269	26	East	East	NNP
cord-016293-pyb00pt5	269	27	side	side	NN
cord-016293-pyb00pt5	269	28	of	of	IN
cord-016293-pyb00pt5	269	29	the	the	DT
cord-016293-pyb00pt5	269	30	Atlantic	Atlantic	NNP
cord-016293-pyb00pt5	269	31	by	by	IN
cord-016293-pyb00pt5	269	32	the	the	DT
cord-016293-pyb00pt5	269	33	HGP	HGP	NNP
cord-016293-pyb00pt5	269	34	team	team	NN
cord-016293-pyb00pt5	269	35	led	lead	VBN
cord-016293-pyb00pt5	269	36	by	by	IN
cord-016293-pyb00pt5	269	37	the	the	DT
cord-016293-pyb00pt5	269	38	Sanger	Sanger	NNP
cord-016293-pyb00pt5	269	39	Centre	Centre	NNP
cord-016293-pyb00pt5	269	40	,	,	,
cord-016293-pyb00pt5	269	41	producing	produce	VBG
cord-016293-pyb00pt5	269	42	a	a	DT
cord-016293-pyb00pt5	269	43	finished	finished	JJ
cord-016293-pyb00pt5	269	44	sequence	sequence	NN
cord-016293-pyb00pt5	269	45	for	for	IN
cord-016293-pyb00pt5	269	46	chromosome	chromosome	NN
cord-016293-pyb00pt5	269	47	22	22	CD
cord-016293-pyb00pt5	269	48	,	,	,
cord-016293-pyb00pt5	269	49	which	which	WDT
cord-016293-pyb00pt5	269	50	is	be	VBZ
cord-016293-pyb00pt5	269	51	about	about	RB
cord-016293-pyb00pt5	269	52	34	34	CD
cord-016293-pyb00pt5	269	53	million	million	CD
cord-016293-pyb00pt5	269	54	base	base	NN
cord-016293-pyb00pt5	269	55	-	-	HYPH
cord-016293-pyb00pt5	269	56	pairs	pair	NNS
cord-016293-pyb00pt5	269	57	and	and	CC
cord-016293-pyb00pt5	269	58	includes	include	VBZ
cord-016293-pyb00pt5	269	59	at	at	IN
cord-016293-pyb00pt5	269	60	least	least	RBS
cord-016293-pyb00pt5	269	61	550	550	CD
cord-016293-pyb00pt5	269	62	genes	gene	NNS
cord-016293-pyb00pt5	269	63	.	.	.
cord-016293-pyb00pt5	270	1	According	accord	VBG
cord-016293-pyb00pt5	270	2	to	to	IN
cord-016293-pyb00pt5	270	3	anecdotal	anecdotal	JJ
cord-016293-pyb00pt5	270	4	evidence	evidence	NN
cord-016293-pyb00pt5	270	5	when	when	WRB
cord-016293-pyb00pt5	270	6	visiting	visit	VBG
cord-016293-pyb00pt5	270	7	his	-PRON-	PRP$
cord-016293-pyb00pt5	270	8	namesake	namesake	NN
cord-016293-pyb00pt5	270	9	centre	centre	NN
cord-016293-pyb00pt5	270	10	,	,	,
cord-016293-pyb00pt5	270	11	Sanger	Sanger	NNP
cord-016293-pyb00pt5	270	12	asked	ask	VBD
cord-016293-pyb00pt5	270	13	:	:	:
cord-016293-pyb00pt5	270	14	"	"	``
cord-016293-pyb00pt5	270	15	What	what	WP
cord-016293-pyb00pt5	270	16	does	do	VBZ
cord-016293-pyb00pt5	270	17	this	this	DT
cord-016293-pyb00pt5	270	18	machine	machine	NN
cord-016293-pyb00pt5	270	19	do	do	VB
cord-016293-pyb00pt5	270	20	then	then	RB
cord-016293-pyb00pt5	270	21	?	?	.
cord-016293-pyb00pt5	270	22	"	"	''
cord-016293-pyb00pt5	270	23	"	"	``
cord-016293-pyb00pt5	270	24	Dideoxy	Dideoxy	NNP
cord-016293-pyb00pt5	270	25	sequencing	sequencing	NN
cord-016293-pyb00pt5	270	26	"	"	''
cord-016293-pyb00pt5	270	27	came	come	VBD
cord-016293-pyb00pt5	270	28	the	the	DT
cord-016293-pyb00pt5	270	29	reply	reply	NN
cord-016293-pyb00pt5	270	30	,	,	,
cord-016293-pyb00pt5	270	31	to	to	TO
cord-016293-pyb00pt5	270	32	which	which	WDT
cord-016293-pyb00pt5	270	33	Fred	Fred	NNP
cord-016293-pyb00pt5	270	34	retorted	retort	VBD
cord-016293-pyb00pt5	270	35	:	:	:
cord-016293-pyb00pt5	270	36	"	"	``
cord-016293-pyb00pt5	270	37	Have	have	VBP
cord-016293-pyb00pt5	270	38	n't	not	RB
cord-016293-pyb00pt5	270	39	they	-PRON-	PRP
cord-016293-pyb00pt5	270	40	come	come	VB
cord-016293-pyb00pt5	270	41	up	up	RP
cord-016293-pyb00pt5	270	42	with	with	IN
cord-016293-pyb00pt5	270	43	anything	anything	NN
cord-016293-pyb00pt5	270	44	better	well	JJR
cord-016293-pyb00pt5	270	45	yet	yet	RB
cord-016293-pyb00pt5	270	46	?	?	.
cord-016293-pyb00pt5	270	47	"	"	''
cord-016293-pyb00pt5	271	1	As	as	IN
cord-016293-pyb00pt5	271	2	will	will	MD
cord-016293-pyb00pt5	271	3	be	be	VB
cord-016293-pyb00pt5	271	4	elaborated	elaborate	VBN
cord-016293-pyb00pt5	271	5	in	in	IN
cord-016293-pyb00pt5	271	6	the	the	DT
cord-016293-pyb00pt5	271	7	final	final	JJ
cord-016293-pyb00pt5	271	8	chapter	chapter	NN
cord-016293-pyb00pt5	271	9	the	the	DT
cord-016293-pyb00pt5	271	10	real	real	JJ
cord-016293-pyb00pt5	271	11	highlight	highlight	NN
cord-016293-pyb00pt5	271	12	of	of	IN
cord-016293-pyb00pt5	271	13	2000	2000	CD
cord-016293-pyb00pt5	271	14	was	be	VBD
cord-016293-pyb00pt5	271	15	production	production	NN
cord-016293-pyb00pt5	271	16	of	of	IN
cord-016293-pyb00pt5	271	17	a	a	DT
cord-016293-pyb00pt5	271	18	'	'	``
cord-016293-pyb00pt5	271	19	working	working	NN
cord-016293-pyb00pt5	271	20	draft	draft	NN
cord-016293-pyb00pt5	271	21	'	'	''
cord-016293-pyb00pt5	271	22	sequence	sequence	NN
cord-016293-pyb00pt5	271	23	of	of	IN
cord-016293-pyb00pt5	271	24	the	the	DT
cord-016293-pyb00pt5	271	25	human	human	JJ
cord-016293-pyb00pt5	271	26	genome	genome	NN
cord-016293-pyb00pt5	271	27	,	,	,
cord-016293-pyb00pt5	271	28	which	which	WDT
cord-016293-pyb00pt5	271	29	was	be	VBD
cord-016293-pyb00pt5	271	30	announced	announce	VBN
cord-016293-pyb00pt5	271	31	simultaneously	simultaneously	RB
cord-016293-pyb00pt5	271	32	in	in	IN
cord-016293-pyb00pt5	271	33	the	the	DT
cord-016293-pyb00pt5	271	34	US	US	NNP
cord-016293-pyb00pt5	271	35	and	and	CC
cord-016293-pyb00pt5	271	36	the	the	DT
cord-016293-pyb00pt5	271	37	UK	UK	NNP
cord-016293-pyb00pt5	271	38	.	.	.
cord-016293-pyb00pt5	272	1	In	in	IN
cord-016293-pyb00pt5	272	2	a	a	DT
cord-016293-pyb00pt5	272	3	joint	joint	JJ
cord-016293-pyb00pt5	272	4	event	event	NN
cord-016293-pyb00pt5	272	5	,	,	,
cord-016293-pyb00pt5	272	6	Celera	Celera	NNP
cord-016293-pyb00pt5	272	7	Genomics	Genomics	NNP
cord-016293-pyb00pt5	272	8	announced	announce	VBD
cord-016293-pyb00pt5	272	9	completion	completion	NN
cord-016293-pyb00pt5	272	10	of	of	IN
cord-016293-pyb00pt5	272	11	their	-PRON-	PRP$
cord-016293-pyb00pt5	272	12	'	'	``
cord-016293-pyb00pt5	272	13	first	first	JJ
cord-016293-pyb00pt5	272	14	assembly	assembly	NN
cord-016293-pyb00pt5	272	15	'	'	''
cord-016293-pyb00pt5	272	16	of	of	IN
cord-016293-pyb00pt5	272	17	the	the	DT
cord-016293-pyb00pt5	272	18	genome	genome	NN
cord-016293-pyb00pt5	272	19	.	.	.
cord-016293-pyb00pt5	273	1	In	in	IN
cord-016293-pyb00pt5	273	2	a	a	DT
cord-016293-pyb00pt5	273	3	remarkable	remarkable	JJ
cord-016293-pyb00pt5	273	4	special	special	JJ
cord-016293-pyb00pt5	273	5	issue	issue	NN
cord-016293-pyb00pt5	273	6	,	,	,
cord-016293-pyb00pt5	273	7	Nature	Nature	NNP
cord-016293-pyb00pt5	273	8	included	include	VBD
cord-016293-pyb00pt5	273	9	a	a	DT
cord-016293-pyb00pt5	273	10	60-page	60-page	JJ
cord-016293-pyb00pt5	273	11	article	article	NN
cord-016293-pyb00pt5	273	12	by	by	IN
cord-016293-pyb00pt5	273	13	the	the	DT
cord-016293-pyb00pt5	273	14	Human	Human	NNP
cord-016293-pyb00pt5	273	15	Genome	Genome	NNP
cord-016293-pyb00pt5	273	16	Project	Project	NNP
cord-016293-pyb00pt5	273	17	partners	partner	NNS
cord-016293-pyb00pt5	273	18	,	,	,
cord-016293-pyb00pt5	273	19	studies	study	NNS
cord-016293-pyb00pt5	273	20	of	of	IN
cord-016293-pyb00pt5	273	21	mapping	mapping	NN
cord-016293-pyb00pt5	273	22	and	and	CC
cord-016293-pyb00pt5	273	23	variation	variation	NN
cord-016293-pyb00pt5	273	24	,	,	,
cord-016293-pyb00pt5	273	25	as	as	RB
cord-016293-pyb00pt5	273	26	well	well	RB
cord-016293-pyb00pt5	273	27	as	as	IN
cord-016293-pyb00pt5	273	28	analysis	analysis	NN
cord-016293-pyb00pt5	273	29	of	of	IN
cord-016293-pyb00pt5	273	30	the	the	DT
cord-016293-pyb00pt5	273	31	sequence	sequence	NN
cord-016293-pyb00pt5	273	32	by	by	IN
cord-016293-pyb00pt5	273	33	experts	expert	NNS
cord-016293-pyb00pt5	273	34	in	in	IN
cord-016293-pyb00pt5	273	35	different	different	JJ
cord-016293-pyb00pt5	273	36	areas	area	NNS
cord-016293-pyb00pt5	273	37	of	of	IN
cord-016293-pyb00pt5	273	38	biology	biology	NN
cord-016293-pyb00pt5	273	39	.	.	.
cord-016293-pyb00pt5	274	1	Science	science	NN
cord-016293-pyb00pt5	274	2	published	publish	VBD
cord-016293-pyb00pt5	274	3	the	the	DT
cord-016293-pyb00pt5	274	4	article	article	NN
cord-016293-pyb00pt5	274	5	by	by	IN
cord-016293-pyb00pt5	274	6	Celera	Celera	NNP
cord-016293-pyb00pt5	274	7	on	on	IN
cord-016293-pyb00pt5	274	8	their	-PRON-	PRP$
cord-016293-pyb00pt5	274	9	assembly	assembly	NN
cord-016293-pyb00pt5	274	10	of	of	IN
cord-016293-pyb00pt5	274	11	HGP	HGP	NNP
cord-016293-pyb00pt5	274	12	and	and	CC
cord-016293-pyb00pt5	274	13	Celera	Celera	NNP
cord-016293-pyb00pt5	274	14	data	datum	NNS
cord-016293-pyb00pt5	274	15	as	as	RB
cord-016293-pyb00pt5	274	16	well	well	RB
cord-016293-pyb00pt5	274	17	as	as	IN
cord-016293-pyb00pt5	274	18	analyses	analysis	NNS
cord-016293-pyb00pt5	274	19	of	of	IN
cord-016293-pyb00pt5	274	20	the	the	DT
cord-016293-pyb00pt5	274	21	use	use	NN
cord-016293-pyb00pt5	274	22	of	of	IN
cord-016293-pyb00pt5	274	23	the	the	DT
cord-016293-pyb00pt5	274	24	sequence	sequence	NN
cord-016293-pyb00pt5	274	25	.	.	.
cord-016293-pyb00pt5	275	1	However	however	RB
cord-016293-pyb00pt5	275	2	to	to	TO
cord-016293-pyb00pt5	275	3	demonstrate	demonstrate	VB
cord-016293-pyb00pt5	275	4	the	the	DT
cord-016293-pyb00pt5	275	5	sensitivity	sensitivity	NN
cord-016293-pyb00pt5	275	6	of	of	IN
cord-016293-pyb00pt5	275	7	the	the	DT
cord-016293-pyb00pt5	275	8	market	market	NN
cord-016293-pyb00pt5	275	9	place	place	NN
cord-016293-pyb00pt5	275	10	to	to	IN
cord-016293-pyb00pt5	275	11	presidential	presidential	JJ
cord-016293-pyb00pt5	275	12	utterances	utterance	NNS
cord-016293-pyb00pt5	275	13	the	the	DT
cord-016293-pyb00pt5	275	14	joint	joint	JJ
cord-016293-pyb00pt5	275	15	appearances	appearance	NNS
cord-016293-pyb00pt5	275	16	by	by	IN
cord-016293-pyb00pt5	275	17	Bill	Bill	NNP
cord-016293-pyb00pt5	275	18	Clinton	Clinton	NNP
cord-016293-pyb00pt5	275	19	and	and	CC
cord-016293-pyb00pt5	275	20	Tony	Tony	NNP
cord-016293-pyb00pt5	275	21	Blair	Blair	NNP
cord-016293-pyb00pt5	275	22	touting	tout	VBG
cord-016293-pyb00pt5	275	23	this	this	DT
cord-016293-pyb00pt5	275	24	major	major	JJ
cord-016293-pyb00pt5	275	25	milestone	milestone	NN
cord-016293-pyb00pt5	275	26	turned	turn	VBD
cord-016293-pyb00pt5	275	27	into	into	IN
cord-016293-pyb00pt5	275	28	a	a	DT
cord-016293-pyb00pt5	275	29	major	major	JJ
cord-016293-pyb00pt5	275	30	cold	cold	JJ
cord-016293-pyb00pt5	275	31	shower	shower	NN
cord-016293-pyb00pt5	275	32	when	when	WRB
cord-016293-pyb00pt5	275	33	Clinton	Clinton	NNP
cord-016293-pyb00pt5	275	34	's	's	POS
cord-016293-pyb00pt5	275	35	reassurance	reassurance	NN
cord-016293-pyb00pt5	275	36	of	of	IN
cord-016293-pyb00pt5	275	37	access	access	NN
cord-016293-pyb00pt5	275	38	of	of	IN
cord-016293-pyb00pt5	275	39	the	the	DT
cord-016293-pyb00pt5	275	40	people	people	NNS
cord-016293-pyb00pt5	275	41	to	to	IN
cord-016293-pyb00pt5	275	42	their	-PRON-	PRP$
cord-016293-pyb00pt5	275	43	genetic	genetic	JJ
cord-016293-pyb00pt5	275	44	information	information	NN
cord-016293-pyb00pt5	275	45	caused	cause	VBD
cord-016293-pyb00pt5	275	46	a	a	DT
cord-016293-pyb00pt5	275	47	precipitous	precipitous	JJ
cord-016293-pyb00pt5	275	48	drop	drop	NN
cord-016293-pyb00pt5	275	49	in	in	IN
cord-016293-pyb00pt5	275	50	Celera	Celera	NNP
cord-016293-pyb00pt5	275	51	's	's	POS
cord-016293-pyb00pt5	275	52	share	share	NN
cord-016293-pyb00pt5	275	53	value	value	NN
cord-016293-pyb00pt5	275	54	overnight	overnight	RB
cord-016293-pyb00pt5	275	55	.	.	.
cord-016293-pyb00pt5	276	1	Clinton	Clinton	NNP
cord-016293-pyb00pt5	276	2	's	's	POS
cord-016293-pyb00pt5	276	3	assurance	assurance	NN
cord-016293-pyb00pt5	276	4	that	that	IN
cord-016293-pyb00pt5	276	5	,	,	,
cord-016293-pyb00pt5	276	6	"	"	``
cord-016293-pyb00pt5	276	7	The	the	DT
cord-016293-pyb00pt5	276	8	effort	effort	NN
cord-016293-pyb00pt5	276	9	to	to	TO
cord-016293-pyb00pt5	276	10	decipher	decipher	VB
cord-016293-pyb00pt5	276	11	the	the	DT
cord-016293-pyb00pt5	276	12	human	human	JJ
cord-016293-pyb00pt5	276	13	genome	genome	NN
cord-016293-pyb00pt5	276	14	will	will	MD
cord-016293-pyb00pt5	276	15	be	be	VB
cord-016293-pyb00pt5	276	16	the	the	DT
cord-016293-pyb00pt5	276	17	scientific	scientific	JJ
cord-016293-pyb00pt5	276	18	breakthrough	breakthrough	NN
cord-016293-pyb00pt5	276	19	of	of	IN
cord-016293-pyb00pt5	276	20	the	the	DT
cord-016293-pyb00pt5	276	21	century	century	NN
cord-016293-pyb00pt5	276	22	-perhaps	-perhaps	NN
cord-016293-pyb00pt5	276	23	of	of	IN
cord-016293-pyb00pt5	276	24	all	all	DT
cord-016293-pyb00pt5	276	25	time	time	NN
cord-016293-pyb00pt5	276	26	.	.	.
cord-016293-pyb00pt5	277	1	We	-PRON-	PRP
cord-016293-pyb00pt5	277	2	have	have	VBP
cord-016293-pyb00pt5	277	3	a	a	DT
cord-016293-pyb00pt5	277	4	profound	profound	JJ
cord-016293-pyb00pt5	277	5	responsibility	responsibility	NN
cord-016293-pyb00pt5	277	6	to	to	TO
cord-016293-pyb00pt5	277	7	ensure	ensure	VB
cord-016293-pyb00pt5	277	8	that	that	IN
cord-016293-pyb00pt5	277	9	the	the	DT
cord-016293-pyb00pt5	277	10	life	life	NN
cord-016293-pyb00pt5	277	11	-	-	HYPH
cord-016293-pyb00pt5	277	12	saving	save	VBG
cord-016293-pyb00pt5	277	13	benefits	benefit	NNS
cord-016293-pyb00pt5	277	14	of	of	IN
cord-016293-pyb00pt5	277	15	any	any	DT
cord-016293-pyb00pt5	277	16	cutting	cutting	JJ
cord-016293-pyb00pt5	277	17	-	-	HYPH
cord-016293-pyb00pt5	277	18	edge	edge	NN
cord-016293-pyb00pt5	277	19	research	research	NN
cord-016293-pyb00pt5	277	20	are	be	VBP
cord-016293-pyb00pt5	277	21	available	available	JJ
cord-016293-pyb00pt5	277	22	to	to	IN
cord-016293-pyb00pt5	277	23	all	all	DT
cord-016293-pyb00pt5	277	24	human	human	JJ
cord-016293-pyb00pt5	277	25	beings	being	NNS
cord-016293-pyb00pt5	277	26	.	.	.
cord-016293-pyb00pt5	277	27	"	"	''
cord-016293-pyb00pt5	278	1	(	(	-LRB-
cord-016293-pyb00pt5	278	2	President	President	NNP
cord-016293-pyb00pt5	278	3	Bill	Bill	NNP
cord-016293-pyb00pt5	278	4	Clinton	Clinton	NNP
cord-016293-pyb00pt5	278	5	,	,	,
cord-016293-pyb00pt5	278	6	Wednesday	Wednesday	NNP
cord-016293-pyb00pt5	278	7	,	,	,
cord-016293-pyb00pt5	278	8	March	March	NNP
cord-016293-pyb00pt5	278	9	14	14	CD
cord-016293-pyb00pt5	278	10	,	,	,
cord-016293-pyb00pt5	278	11	2000	2000	CD
cord-016293-pyb00pt5	278	12	)	)	-RRB-
cord-016293-pyb00pt5	278	13	stands	stand	VBZ
cord-016293-pyb00pt5	278	14	in	in	IN
cord-016293-pyb00pt5	278	15	sharp	sharp	JJ
cord-016293-pyb00pt5	278	16	contrast	contrast	NN
cord-016293-pyb00pt5	278	17	to	to	IN
cord-016293-pyb00pt5	278	18	the	the	DT
cord-016293-pyb00pt5	278	19	statement	statement	NN
cord-016293-pyb00pt5	278	20	from	from	IN
cord-016293-pyb00pt5	278	21	Venter	Venter	NNP
cord-016293-pyb00pt5	278	22	's	's	POS
cord-016293-pyb00pt5	278	23	Colleague	colleague	NN
cord-016293-pyb00pt5	278	24	that	that	IN
cord-016293-pyb00pt5	278	25	"	"	``
cord-016293-pyb00pt5	278	26	Any	any	DT
cord-016293-pyb00pt5	278	27	company	company	NN
cord-016293-pyb00pt5	278	28	that	that	WDT
cord-016293-pyb00pt5	278	29	wants	want	VBZ
cord-016293-pyb00pt5	278	30	to	to	TO
cord-016293-pyb00pt5	278	31	be	be	VB
cord-016293-pyb00pt5	278	32	in	in	IN
cord-016293-pyb00pt5	278	33	the	the	DT
cord-016293-pyb00pt5	278	34	business	business	NN
cord-016293-pyb00pt5	278	35	of	of	IN
cord-016293-pyb00pt5	278	36	using	use	VBG
cord-016293-pyb00pt5	278	37	genes	gene	NNS
cord-016293-pyb00pt5	278	38	,	,	,
cord-016293-pyb00pt5	278	39	proteins	protein	NNS
cord-016293-pyb00pt5	278	40	,	,	,
cord-016293-pyb00pt5	278	41	or	or	CC
cord-016293-pyb00pt5	278	42	antibodies	antibody	NNS
cord-016293-pyb00pt5	278	43	as	as	IN
cord-016293-pyb00pt5	278	44	drugs	drug	NNS
cord-016293-pyb00pt5	278	45	has	have	VBZ
cord-016293-pyb00pt5	278	46	a	a	DT
cord-016293-pyb00pt5	278	47	very	very	RB
cord-016293-pyb00pt5	278	48	high	high	JJ
cord-016293-pyb00pt5	278	49	probability	probability	NN
cord-016293-pyb00pt5	278	50	of	of	IN
cord-016293-pyb00pt5	278	51	running	run	VBG
cord-016293-pyb00pt5	278	52	afoul	afoul	IN
cord-016293-pyb00pt5	278	53	of	of	IN
cord-016293-pyb00pt5	278	54	our	-PRON-	PRP$
cord-016293-pyb00pt5	278	55	patents	patent	NNS
cord-016293-pyb00pt5	278	56	.	.	.
cord-016293-pyb00pt5	279	1	From	from	IN
cord-016293-pyb00pt5	279	2	a	a	DT
cord-016293-pyb00pt5	279	3	commercial	commercial	JJ
cord-016293-pyb00pt5	279	4	point	point	NN
cord-016293-pyb00pt5	279	5	of	of	IN
cord-016293-pyb00pt5	279	6	view	view	NN
cord-016293-pyb00pt5	279	7	,	,	,
cord-016293-pyb00pt5	279	8	they	-PRON-	PRP
cord-016293-pyb00pt5	279	9	are	be	VBP
cord-016293-pyb00pt5	279	10	severely	severely	RB
cord-016293-pyb00pt5	279	11	constrained	constrain	VBN
cord-016293-pyb00pt5	279	12	-and	-and	:
cord-016293-pyb00pt5	279	13	far	far	RB
cord-016293-pyb00pt5	279	14	more	more	JJR
cord-016293-pyb00pt5	279	15	than	than	IN
cord-016293-pyb00pt5	279	16	they	-PRON-	PRP
cord-016293-pyb00pt5	279	17	realize	realize	VBP
cord-016293-pyb00pt5	279	18	.	.	.
cord-016293-pyb00pt5	279	19	"	"	''
cord-016293-pyb00pt5	280	1	(	(	-LRB-
cord-016293-pyb00pt5	280	2	William	William	NNP
cord-016293-pyb00pt5	280	3	A.	A.	NNP
cord-016293-pyb00pt5	280	4	Haseltine	Haseltine	NNP
cord-016293-pyb00pt5	280	5	,	,	,
cord-016293-pyb00pt5	280	6	Chairman	Chairman	NNP
cord-016293-pyb00pt5	280	7	and	and	CC
cord-016293-pyb00pt5	280	8	CEO	CEO	NNP
cord-016293-pyb00pt5	280	9	,	,	,
cord-016293-pyb00pt5	280	10	Human	Human	NNP
cord-016293-pyb00pt5	280	11	Genome	Genome	NNP
cord-016293-pyb00pt5	280	12	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	280	13	)	)	-RRB-
cord-016293-pyb00pt5	280	14	.	.	.
cord-016293-pyb00pt5	281	1	The	the	DT
cord-016293-pyb00pt5	281	2	huge	huge	JJ
cord-016293-pyb00pt5	281	3	sell	sell	NN
cord-016293-pyb00pt5	281	4	-	-	HYPH
cord-016293-pyb00pt5	281	5	off	off	NN
cord-016293-pyb00pt5	281	6	in	in	IN
cord-016293-pyb00pt5	281	7	stocks	stock	NNS
cord-016293-pyb00pt5	281	8	ended	end	VBD
cord-016293-pyb00pt5	281	9	weeks	week	NNS
cord-016293-pyb00pt5	281	10	of	of	IN
cord-016293-pyb00pt5	281	11	biotech	biotech	NN
cord-016293-pyb00pt5	281	12	buying	buying	NN
cord-016293-pyb00pt5	281	13	in	in	IN
cord-016293-pyb00pt5	281	14	which	which	WDT
cord-016293-pyb00pt5	281	15	those	those	DT
cord-016293-pyb00pt5	281	16	same	same	JJ
cord-016293-pyb00pt5	281	17	stocks	stock	NNS
cord-016293-pyb00pt5	281	18	soared	soar	VBD
cord-016293-pyb00pt5	281	19	to	to	IN
cord-016293-pyb00pt5	281	20	unprecedented	unprecedented	JJ
cord-016293-pyb00pt5	281	21	highs	high	NNS
cord-016293-pyb00pt5	281	22	.	.	.
cord-016293-pyb00pt5	282	1	By	by	IN
cord-016293-pyb00pt5	282	2	the	the	DT
cord-016293-pyb00pt5	282	3	next	next	JJ
cord-016293-pyb00pt5	282	4	day	day	NN
cord-016293-pyb00pt5	282	5	,	,	,
cord-016293-pyb00pt5	282	6	however	however	RB
cord-016293-pyb00pt5	282	7	,	,	,
cord-016293-pyb00pt5	282	8	the	the	DT
cord-016293-pyb00pt5	282	9	genomic	genomic	JJ
cord-016293-pyb00pt5	282	10	company	company	NN
cord-016293-pyb00pt5	282	11	spin	spin	VBP
cord-016293-pyb00pt5	282	12	doctors	doctor	NNS
cord-016293-pyb00pt5	282	13	began	begin	VBD
cord-016293-pyb00pt5	282	14	to	to	TO
cord-016293-pyb00pt5	282	15	recover	recover	VB
cord-016293-pyb00pt5	282	16	ground	ground	NN
cord-016293-pyb00pt5	282	17	in	in	IN
cord-016293-pyb00pt5	282	18	a	a	DT
cord-016293-pyb00pt5	282	19	brilliant	brilliant	JJ
cord-016293-pyb00pt5	282	20	move	move	NN
cord-016293-pyb00pt5	282	21	which	which	WDT
cord-016293-pyb00pt5	282	22	turned	turn	VBD
cord-016293-pyb00pt5	282	23	the	the	DT
cord-016293-pyb00pt5	282	24	Clinton	Clinton	NNP
cord-016293-pyb00pt5	282	25	announcement	announcement	NN
cord-016293-pyb00pt5	282	26	into	into	IN
cord-016293-pyb00pt5	282	27	a	a	DT
cord-016293-pyb00pt5	282	28	public	public	JJ
cord-016293-pyb00pt5	282	29	relations	relation	NNS
cord-016293-pyb00pt5	282	30	coup	coup	NN
cord-016293-pyb00pt5	282	31	.	.	.
cord-016293-pyb00pt5	283	1	All	all	DT
cord-016293-pyb00pt5	283	2	major	major	JJ
cord-016293-pyb00pt5	283	3	genomics	genomic	NNS
cord-016293-pyb00pt5	283	4	companies	company	NNS
cord-016293-pyb00pt5	283	5	issued	issue	VBD
cord-016293-pyb00pt5	283	6	press	press	NN
cord-016293-pyb00pt5	283	7	releases	release	NNS
cord-016293-pyb00pt5	283	8	applauding	applaud	VBG
cord-016293-pyb00pt5	283	9	President	President	NNP
cord-016293-pyb00pt5	283	10	Clinton	Clinton	NNP
cord-016293-pyb00pt5	283	11	's	's	POS
cord-016293-pyb00pt5	283	12	announcement	announcement	NN
cord-016293-pyb00pt5	283	13	.	.	.
cord-016293-pyb00pt5	284	1	The	the	DT
cord-016293-pyb00pt5	284	2	real	real	JJ
cord-016293-pyb00pt5	284	3	news	news	NN
cord-016293-pyb00pt5	284	4	they	-PRON-	PRP
cord-016293-pyb00pt5	284	5	argued	argue	VBD
cord-016293-pyb00pt5	284	6	,	,	,
cord-016293-pyb00pt5	284	7	was	be	VBD
cord-016293-pyb00pt5	284	8	that	that	IN
cord-016293-pyb00pt5	284	9	"	"	``
cord-016293-pyb00pt5	284	10	for	for	IN
cord-016293-pyb00pt5	284	11	the	the	DT
cord-016293-pyb00pt5	284	12	first	first	JJ
cord-016293-pyb00pt5	284	13	time	time	NN
cord-016293-pyb00pt5	284	14	a	a	DT
cord-016293-pyb00pt5	284	15	President	President	NNP
cord-016293-pyb00pt5	284	16	strongly	strongly	RB
cord-016293-pyb00pt5	284	17	affirmed	affirm	VBD
cord-016293-pyb00pt5	284	18	the	the	DT
cord-016293-pyb00pt5	284	19	importance	importance	NN
cord-016293-pyb00pt5	284	20	of	of	IN
cord-016293-pyb00pt5	284	21	gene	gene	NN
cord-016293-pyb00pt5	284	22	based	base	VBN
cord-016293-pyb00pt5	284	23	patents	patent	NNS
cord-016293-pyb00pt5	284	24	.	.	.
cord-016293-pyb00pt5	284	25	"	"	''
cord-016293-pyb00pt5	285	1	And	and	CC
cord-016293-pyb00pt5	285	2	the	the	DT
cord-016293-pyb00pt5	285	3	same	same	JJ
cord-016293-pyb00pt5	285	4	Bill	Bill	NNP
cord-016293-pyb00pt5	285	5	Haseltine	Haseltine	NNP
cord-016293-pyb00pt5	285	6	of	of	IN
cord-016293-pyb00pt5	285	7	Human	Human	NNP
cord-016293-pyb00pt5	285	8	Genome	Genome	NNP
cord-016293-pyb00pt5	285	9	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	285	10	positively	positively	RB
cord-016293-pyb00pt5	285	11	gushed	gush	VBD
cord-016293-pyb00pt5	285	12	as	as	IN
cord-016293-pyb00pt5	285	13	he	-PRON-	PRP
cord-016293-pyb00pt5	285	14	happily	happily	RB
cord-016293-pyb00pt5	285	15	pointed	point	VBD
cord-016293-pyb00pt5	285	16	out	out	RP
cord-016293-pyb00pt5	285	17	that	that	IN
cord-016293-pyb00pt5	285	18	he	-PRON-	PRP
cord-016293-pyb00pt5	285	19	"	"	``
cord-016293-pyb00pt5	285	20	could	could	MD
cord-016293-pyb00pt5	285	21	begin	begin	VB
cord-016293-pyb00pt5	285	22	his	-PRON-	PRP$
cord-016293-pyb00pt5	285	23	next	next	JJ
cord-016293-pyb00pt5	285	24	annual	annual	JJ
cord-016293-pyb00pt5	285	25	report	report	NN
cord-016293-pyb00pt5	285	26	with	with	IN
cord-016293-pyb00pt5	285	27	the	the	DT
cord-016293-pyb00pt5	285	28	[	[	-LRB-
cord-016293-pyb00pt5	285	29	President	President	NNP
cord-016293-pyb00pt5	285	30	's	's	POS
cord-016293-pyb00pt5	285	31	]	]	-RRB-
cord-016293-pyb00pt5	285	32	monumental	monumental	JJ
cord-016293-pyb00pt5	285	33	statement	statement	NN
cord-016293-pyb00pt5	285	34	,	,	,
cord-016293-pyb00pt5	285	35	and	and	CC
cord-016293-pyb00pt5	285	36	quote	quote	UH
cord-016293-pyb00pt5	285	37	today	today	NN
cord-016293-pyb00pt5	285	38	as	as	IN
cord-016293-pyb00pt5	285	39	a	a	DT
cord-016293-pyb00pt5	285	40	monumental	monumental	JJ
cord-016293-pyb00pt5	285	41	day	day	NN
cord-016293-pyb00pt5	285	42	.	.	.
cord-016293-pyb00pt5	285	43	"	"	''
cord-016293-pyb00pt5	286	1	As	as	IN
cord-016293-pyb00pt5	286	2	distinguished	distinguished	JJ
cord-016293-pyb00pt5	286	3	Harvard	Harvard	NNP
cord-016293-pyb00pt5	286	4	biologist	biologist	NN
cord-016293-pyb00pt5	286	5	Richard	Richard	NNP
cord-016293-pyb00pt5	286	6	Lewontin	Lewontin	NNP
cord-016293-pyb00pt5	286	7	notes	note	VBZ
cord-016293-pyb00pt5	286	8	:	:	:
cord-016293-pyb00pt5	286	9	"	"	``
cord-016293-pyb00pt5	286	10	No	no	DT
cord-016293-pyb00pt5	286	11	prominent	prominent	JJ
cord-016293-pyb00pt5	286	12	molecular	molecular	JJ
cord-016293-pyb00pt5	286	13	biologist	biologist	NN
cord-016293-pyb00pt5	286	14	of	of	IN
cord-016293-pyb00pt5	286	15	my	-PRON-	PRP$
cord-016293-pyb00pt5	286	16	acquaintance	acquaintance	NN
cord-016293-pyb00pt5	286	17	is	be	VBZ
cord-016293-pyb00pt5	286	18	without	without	IN
cord-016293-pyb00pt5	286	19	a	a	DT
cord-016293-pyb00pt5	286	20	financial	financial	JJ
cord-016293-pyb00pt5	286	21	stake	stake	NN
cord-016293-pyb00pt5	286	22	in	in	IN
cord-016293-pyb00pt5	286	23	the	the	DT
cord-016293-pyb00pt5	286	24	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	286	25	business	business	NN
cord-016293-pyb00pt5	286	26	.	.	.
cord-016293-pyb00pt5	287	1	As	as	IN
cord-016293-pyb00pt5	287	2	a	a	DT
cord-016293-pyb00pt5	287	3	result	result	NN
cord-016293-pyb00pt5	287	4	,	,	,
cord-016293-pyb00pt5	287	5	serious	serious	JJ
cord-016293-pyb00pt5	287	6	conflicts	conflict	NNS
cord-016293-pyb00pt5	287	7	of	of	IN
cord-016293-pyb00pt5	287	8	interest	interest	NN
cord-016293-pyb00pt5	287	9	have	have	VBP
cord-016293-pyb00pt5	287	10	emerged	emerge	VBN
cord-016293-pyb00pt5	287	11	in	in	IN
cord-016293-pyb00pt5	287	12	universities	university	NNS
cord-016293-pyb00pt5	287	13	and	and	CC
cord-016293-pyb00pt5	287	14	in	in	IN
cord-016293-pyb00pt5	287	15	government	government	NN
cord-016293-pyb00pt5	287	16	service	service	NN
cord-016293-pyb00pt5	287	17	(	(	-LRB-
cord-016293-pyb00pt5	287	18	Lewontin	Lewontin	NNP
cord-016293-pyb00pt5	287	19	,	,	,
cord-016293-pyb00pt5	287	20	2000	2000	CD
cord-016293-pyb00pt5	287	21	)	)	-RRB-
cord-016293-pyb00pt5	287	22	.	.	.
cord-016293-pyb00pt5	288	1	Away	away	RB
cord-016293-pyb00pt5	288	2	from	from	IN
cord-016293-pyb00pt5	288	3	the	the	DT
cord-016293-pyb00pt5	288	4	spin	spin	NN
cord-016293-pyb00pt5	288	5	doctors	doctor	NNS
cord-016293-pyb00pt5	288	6	perhaps	perhaps	RB
cord-016293-pyb00pt5	288	7	Eric	Eric	NNP
cord-016293-pyb00pt5	288	8	Lander	Lander	NNP
cord-016293-pyb00pt5	288	9	may	may	MD
cord-016293-pyb00pt5	288	10	have	have	VB
cord-016293-pyb00pt5	288	11	best	well	RBS
cord-016293-pyb00pt5	288	12	summed	sum	VBN
cord-016293-pyb00pt5	288	13	up	up	RP
cord-016293-pyb00pt5	288	14	the	the	DT
cord-016293-pyb00pt5	288	15	Herculean	herculean	JJ
cord-016293-pyb00pt5	288	16	effort	effort	NN
cord-016293-pyb00pt5	288	17	when	when	WRB
cord-016293-pyb00pt5	288	18	he	-PRON-	PRP
cord-016293-pyb00pt5	288	19	opined	opine	VBD
cord-016293-pyb00pt5	288	20	that	that	IN
cord-016293-pyb00pt5	288	21	for	for	IN
cord-016293-pyb00pt5	288	22	him	-PRON-	PRP
cord-016293-pyb00pt5	288	23	"	"	``
cord-016293-pyb00pt5	288	24	the	the	DT
cord-016293-pyb00pt5	288	25	Human	Human	NNP
cord-016293-pyb00pt5	288	26	Genome	Genome	NNP
cord-016293-pyb00pt5	288	27	Project	Project	NNP
cord-016293-pyb00pt5	288	28	has	have	VBZ
cord-016293-pyb00pt5	288	29	been	be	VBN
cord-016293-pyb00pt5	288	30	the	the	DT
cord-016293-pyb00pt5	288	31	ultimate	ultimate	JJ
cord-016293-pyb00pt5	288	32	fulfilment	fulfilment	NN
cord-016293-pyb00pt5	288	33	:	:	:
cord-016293-pyb00pt5	288	34	the	the	DT
cord-016293-pyb00pt5	288	35	chance	chance	NN
cord-016293-pyb00pt5	288	36	to	to	TO
cord-016293-pyb00pt5	288	37	share	share	VB
cord-016293-pyb00pt5	288	38	common	common	JJ
cord-016293-pyb00pt5	288	39	purpose	purpose	NN
cord-016293-pyb00pt5	288	40	with	with	IN
cord-016293-pyb00pt5	288	41	hundreds	hundred	NNS
cord-016293-pyb00pt5	288	42	of	of	IN
cord-016293-pyb00pt5	288	43	wonderful	wonderful	JJ
cord-016293-pyb00pt5	288	44	colleagues	colleague	NNS
cord-016293-pyb00pt5	288	45	towards	towards	IN
cord-016293-pyb00pt5	288	46	a	a	DT
cord-016293-pyb00pt5	288	47	goal	goal	NN
cord-016293-pyb00pt5	288	48	larger	large	JJR
cord-016293-pyb00pt5	288	49	than	than	IN
cord-016293-pyb00pt5	288	50	ourselves	-PRON-	PRP
cord-016293-pyb00pt5	288	51	.	.	.
cord-016293-pyb00pt5	289	1	In	in	IN
cord-016293-pyb00pt5	289	2	the	the	DT
cord-016293-pyb00pt5	289	3	long	long	JJ
cord-016293-pyb00pt5	289	4	run	run	NN
cord-016293-pyb00pt5	289	5	,	,	,
cord-016293-pyb00pt5	289	6	the	the	DT
cord-016293-pyb00pt5	289	7	Human	Human	NNP
cord-016293-pyb00pt5	289	8	Genome	Genome	NNP
cord-016293-pyb00pt5	289	9	Project	Project	NNP
cord-016293-pyb00pt5	289	10	's	's	POS
cord-016293-pyb00pt5	289	11	greatest	great	JJS
cord-016293-pyb00pt5	289	12	impact	impact	NN
cord-016293-pyb00pt5	289	13	might	may	MD
cord-016293-pyb00pt5	289	14	not	not	RB
cord-016293-pyb00pt5	289	15	be	be	VB
cord-016293-pyb00pt5	289	16	the	the	DT
cord-016293-pyb00pt5	289	17	three	three	CD
cord-016293-pyb00pt5	289	18	billion	billion	CD
cord-016293-pyb00pt5	289	19	nucleotides	nucleotide	NNS
cord-016293-pyb00pt5	289	20	of	of	IN
cord-016293-pyb00pt5	289	21	the	the	DT
cord-016293-pyb00pt5	289	22	human	human	JJ
cord-016293-pyb00pt5	289	23	chromosomes	chromosome	NNS
cord-016293-pyb00pt5	289	24	,	,	,
cord-016293-pyb00pt5	289	25	but	but	CC
cord-016293-pyb00pt5	289	26	its	-PRON-	PRP$
cord-016293-pyb00pt5	289	27	model	model	NN
cord-016293-pyb00pt5	289	28	of	of	IN
cord-016293-pyb00pt5	289	29	scientific	scientific	JJ
cord-016293-pyb00pt5	289	30	community	community	NN
cord-016293-pyb00pt5	289	31	.	.	.
cord-016293-pyb00pt5	289	32	"	"	''
cord-016293-pyb00pt5	290	1	(	(	-LRB-
cord-016293-pyb00pt5	290	2	Ridley	Ridley	NNP
cord-016293-pyb00pt5	290	3	,	,	,
cord-016293-pyb00pt5	290	4	2000	2000	CD
cord-016293-pyb00pt5	290	5	)	)	-RRB-
cord-016293-pyb00pt5	290	6	6	6	CD
cord-016293-pyb00pt5	290	7	.	.	.
cord-016293-pyb00pt5	291	1	GENE	gene	NN
cord-016293-pyb00pt5	291	2	THERAPY	THERAPY	NNP
cord-016293-pyb00pt5	292	1	The	the	DT
cord-016293-pyb00pt5	292	2	year	year	NN
cord-016293-pyb00pt5	292	3	1990	1990	CD
cord-016293-pyb00pt5	292	4	also	also	RB
cord-016293-pyb00pt5	292	5	marked	mark	VBD
cord-016293-pyb00pt5	292	6	the	the	DT
cord-016293-pyb00pt5	292	7	passing	passing	NN
cord-016293-pyb00pt5	292	8	of	of	IN
cord-016293-pyb00pt5	292	9	another	another	DT
cord-016293-pyb00pt5	292	10	milestone	milestone	NN
cord-016293-pyb00pt5	292	11	that	that	WDT
cord-016293-pyb00pt5	292	12	was	be	VBD
cord-016293-pyb00pt5	292	13	intimately	intimately	RB
cord-016293-pyb00pt5	292	14	connected	connect	VBN
cord-016293-pyb00pt5	292	15	to	to	IN
cord-016293-pyb00pt5	292	16	one	one	CD
cord-016293-pyb00pt5	292	17	of	of	IN
cord-016293-pyb00pt5	292	18	the	the	DT
cord-016293-pyb00pt5	292	19	fundamental	fundamental	JJ
cord-016293-pyb00pt5	292	20	drivers	driver	NNS
cord-016293-pyb00pt5	292	21	of	of	IN
cord-016293-pyb00pt5	292	22	the	the	DT
cord-016293-pyb00pt5	292	23	HGP	HGP	NNP
cord-016293-pyb00pt5	292	24	.	.	.
cord-016293-pyb00pt5	293	1	The	the	DT
cord-016293-pyb00pt5	293	2	California	California	NNP
cord-016293-pyb00pt5	293	3	Hereditary	Hereditary	NNP
cord-016293-pyb00pt5	293	4	Disorders	Disorders	NNPS
cord-016293-pyb00pt5	293	5	Act	Act	NNP
cord-016293-pyb00pt5	293	6	came	come	VBD
cord-016293-pyb00pt5	293	7	into	into	IN
cord-016293-pyb00pt5	293	8	force	force	NN
cord-016293-pyb00pt5	293	9	and	and	CC
cord-016293-pyb00pt5	293	10	with	with	IN
cord-016293-pyb00pt5	293	11	it	-PRON-	PRP
cord-016293-pyb00pt5	293	12	one	one	CD
cord-016293-pyb00pt5	293	13	of	of	IN
cord-016293-pyb00pt5	293	14	the	the	DT
cord-016293-pyb00pt5	293	15	potential	potential	JJ
cord-016293-pyb00pt5	293	16	solutions	solution	NNS
cord-016293-pyb00pt5	293	17	for	for	IN
cord-016293-pyb00pt5	293	18	human	human	JJ
cord-016293-pyb00pt5	293	19	hereditary	hereditary	JJ
cord-016293-pyb00pt5	293	20	disorders	disorder	NNS
cord-016293-pyb00pt5	293	21	.	.	.
cord-016293-pyb00pt5	294	1	W.	W.	NNP
cord-016293-pyb00pt5	294	2	French	French	NNP
cord-016293-pyb00pt5	294	3	Anderson	Anderson	NNP
cord-016293-pyb00pt5	294	4	in	in	IN
cord-016293-pyb00pt5	294	5	the	the	DT
cord-016293-pyb00pt5	294	6	USA	USA	NNP
cord-016293-pyb00pt5	294	7	reported	report	VBD
cord-016293-pyb00pt5	294	8	the	the	DT
cord-016293-pyb00pt5	294	9	first	first	JJ
cord-016293-pyb00pt5	294	10	successful	successful	JJ
cord-016293-pyb00pt5	294	11	application	application	NN
cord-016293-pyb00pt5	294	12	of	of	IN
cord-016293-pyb00pt5	294	13	gene	gene	NN
cord-016293-pyb00pt5	294	14	therapy	therapy	NN
cord-016293-pyb00pt5	294	15	in	in	IN
cord-016293-pyb00pt5	294	16	humans	human	NNS
cord-016293-pyb00pt5	294	17	.	.	.
cord-016293-pyb00pt5	295	1	The	the	DT
cord-016293-pyb00pt5	295	2	first	first	JJ
cord-016293-pyb00pt5	295	3	successful	successful	JJ
cord-016293-pyb00pt5	295	4	gene	gene	NN
cord-016293-pyb00pt5	295	5	therapy	therapy	NN
cord-016293-pyb00pt5	295	6	for	for	IN
cord-016293-pyb00pt5	295	7	a	a	DT
cord-016293-pyb00pt5	295	8	human	human	JJ
cord-016293-pyb00pt5	295	9	disease	disease	NN
cord-016293-pyb00pt5	295	10	was	be	VBD
cord-016293-pyb00pt5	295	11	successfully	successfully	RB
cord-016293-pyb00pt5	295	12	achieved	achieve	VBN
cord-016293-pyb00pt5	295	13	for	for	IN
cord-016293-pyb00pt5	295	14	Severe	severe	JJ
cord-016293-pyb00pt5	295	15	Combined	combined	JJ
cord-016293-pyb00pt5	295	16	Immune	immune	JJ
cord-016293-pyb00pt5	295	17	Deficiency	deficiency	NN
cord-016293-pyb00pt5	295	18	(	(	-LRB-
cord-016293-pyb00pt5	295	19	SCID	SCID	NNP
cord-016293-pyb00pt5	295	20	)	)	-RRB-
cord-016293-pyb00pt5	295	21	by	by	IN
cord-016293-pyb00pt5	295	22	introducing	introduce	VBG
cord-016293-pyb00pt5	295	23	the	the	DT
cord-016293-pyb00pt5	295	24	missing	miss	VBG
cord-016293-pyb00pt5	295	25	gene	gene	NN
cord-016293-pyb00pt5	295	26	,	,	,
cord-016293-pyb00pt5	295	27	adenosine	adenosine	NN
cord-016293-pyb00pt5	295	28	deaminase	deaminase	NNP
cord-016293-pyb00pt5	295	29	deficiency	deficiency	NN
cord-016293-pyb00pt5	295	30	(	(	-LRB-
cord-016293-pyb00pt5	295	31	ADA	ADA	NNP
cord-016293-pyb00pt5	295	32	)	)	-RRB-
cord-016293-pyb00pt5	295	33	into	into	IN
cord-016293-pyb00pt5	295	34	the	the	DT
cord-016293-pyb00pt5	295	35	peripheral	peripheral	JJ
cord-016293-pyb00pt5	295	36	lymphocytes	lymphocyte	NNS
cord-016293-pyb00pt5	295	37	of	of	IN
cord-016293-pyb00pt5	295	38	a	a	DT
cord-016293-pyb00pt5	295	39	4-year	4-year	JJ
cord-016293-pyb00pt5	295	40	-	-	HYPH
cord-016293-pyb00pt5	295	41	old	old	JJ
cord-016293-pyb00pt5	295	42	girl	girl	NN
cord-016293-pyb00pt5	295	43	and	and	CC
cord-016293-pyb00pt5	295	44	returning	return	VBG
cord-016293-pyb00pt5	295	45	modified	modify	VBN
cord-016293-pyb00pt5	295	46	lymphocytes	lymphocyte	NNS
cord-016293-pyb00pt5	295	47	to	to	IN
cord-016293-pyb00pt5	295	48	her	-PRON-	PRP
cord-016293-pyb00pt5	295	49	.	.	.
cord-016293-pyb00pt5	296	1	Although	although	IN
cord-016293-pyb00pt5	296	2	the	the	DT
cord-016293-pyb00pt5	296	3	results	result	NNS
cord-016293-pyb00pt5	296	4	are	be	VBP
cord-016293-pyb00pt5	296	5	difficult	difficult	JJ
cord-016293-pyb00pt5	296	6	to	to	TO
cord-016293-pyb00pt5	296	7	interpret	interpret	VB
cord-016293-pyb00pt5	296	8	because	because	IN
cord-016293-pyb00pt5	296	9	of	of	IN
cord-016293-pyb00pt5	296	10	the	the	DT
cord-016293-pyb00pt5	296	11	concurrent	concurrent	JJ
cord-016293-pyb00pt5	296	12	use	use	NN
cord-016293-pyb00pt5	296	13	of	of	IN
cord-016293-pyb00pt5	296	14	polyethylene	polyethylene	NN
cord-016293-pyb00pt5	296	15	glycol	glycol	NN
cord-016293-pyb00pt5	296	16	-	-	HYPH
cord-016293-pyb00pt5	296	17	conjugated	conjugate	VBN
cord-016293-pyb00pt5	296	18	ADA	ADA	NNP
cord-016293-pyb00pt5	296	19	commonly	commonly	RB
cord-016293-pyb00pt5	296	20	referred	refer	VBD
cord-016293-pyb00pt5	296	21	to	to	IN
cord-016293-pyb00pt5	296	22	as	as	RB
cord-016293-pyb00pt5	296	23	pegylated	pegylate	VBN
cord-016293-pyb00pt5	296	24	ADA	ADA	NNP
cord-016293-pyb00pt5	296	25	(	(	-LRB-
cord-016293-pyb00pt5	296	26	PGLA	PGLA	NNP
cord-016293-pyb00pt5	296	27	)	)	-RRB-
cord-016293-pyb00pt5	296	28	in	in	IN
cord-016293-pyb00pt5	296	29	all	all	DT
cord-016293-pyb00pt5	296	30	patients	patient	NNS
cord-016293-pyb00pt5	296	31	,	,	,
cord-016293-pyb00pt5	296	32	strong	strong	JJ
cord-016293-pyb00pt5	296	33	evidence	evidence	NN
cord-016293-pyb00pt5	296	34	for	for	IN
cord-016293-pyb00pt5	296	35	in	in	IN
cord-016293-pyb00pt5	296	36	vivo	vivo	NN
cord-016293-pyb00pt5	296	37	efficacy	efficacy	NN
cord-016293-pyb00pt5	296	38	was	be	VBD
cord-016293-pyb00pt5	296	39	demonstrated	demonstrate	VBN
cord-016293-pyb00pt5	296	40	.	.	.
cord-016293-pyb00pt5	297	1	ADA	ADA	NNP
cord-016293-pyb00pt5	297	2	-	-	HYPH
cord-016293-pyb00pt5	297	3	modified	modify	VBN
cord-016293-pyb00pt5	297	4	T	T	NNP
cord-016293-pyb00pt5	297	5	cells	cell	NNS
cord-016293-pyb00pt5	297	6	persisted	persist	VBD
cord-016293-pyb00pt5	297	7	in	in	IN
cord-016293-pyb00pt5	297	8	vivo	vivo	NN
cord-016293-pyb00pt5	297	9	for	for	IN
cord-016293-pyb00pt5	297	10	up	up	IN
cord-016293-pyb00pt5	297	11	to	to	TO
cord-016293-pyb00pt5	297	12	three	three	CD
cord-016293-pyb00pt5	297	13	years	year	NNS
cord-016293-pyb00pt5	297	14	and	and	CC
cord-016293-pyb00pt5	297	15	were	be	VBD
cord-016293-pyb00pt5	297	16	associated	associate	VBN
cord-016293-pyb00pt5	297	17	with	with	IN
cord-016293-pyb00pt5	297	18	increases	increase	NNS
cord-016293-pyb00pt5	297	19	in	in	IN
cord-016293-pyb00pt5	297	20	T	t	NN
cord-016293-pyb00pt5	297	21	-	-	HYPH
cord-016293-pyb00pt5	297	22	cell	cell	NN
cord-016293-pyb00pt5	297	23	number	number	NN
cord-016293-pyb00pt5	297	24	and	and	CC
cord-016293-pyb00pt5	297	25	ADA	ADA	NNP
cord-016293-pyb00pt5	297	26	enzyme	enzyme	NN
cord-016293-pyb00pt5	297	27	levels	level	NNS
cord-016293-pyb00pt5	297	28	,	,	,
cord-016293-pyb00pt5	297	29	T	t	NN
cord-016293-pyb00pt5	297	30	cells	cell	NNS
cord-016293-pyb00pt5	297	31	derived	derive	VBN
cord-016293-pyb00pt5	297	32	from	from	IN
cord-016293-pyb00pt5	297	33	transduced	transduce	VBN
cord-016293-pyb00pt5	297	34	PGLA	PGLA	NNP
cord-016293-pyb00pt5	297	35	were	be	VBD
cord-016293-pyb00pt5	297	36	progressively	progressively	RB
cord-016293-pyb00pt5	297	37	replaced	replace	VBN
cord-016293-pyb00pt5	297	38	by	by	IN
cord-016293-pyb00pt5	297	39	marrow	marrow	NN
cord-016293-pyb00pt5	297	40	-	-	HYPH
cord-016293-pyb00pt5	297	41	derived	derive	VBN
cord-016293-pyb00pt5	297	42	T	t	NN
cord-016293-pyb00pt5	297	43	cells	cell	NNS
cord-016293-pyb00pt5	297	44	,	,	,
cord-016293-pyb00pt5	297	45	confirming	confirm	VBG
cord-016293-pyb00pt5	297	46	successful	successful	JJ
cord-016293-pyb00pt5	297	47	gene	gene	NN
cord-016293-pyb00pt5	297	48	transfer	transfer	NN
cord-016293-pyb00pt5	297	49	into	into	IN
cord-016293-pyb00pt5	297	50	long	long	RB
cord-016293-pyb00pt5	297	51	-	-	HYPH
cord-016293-pyb00pt5	297	52	lived	live	VBN
cord-016293-pyb00pt5	297	53	progenitor	progenitor	NN
cord-016293-pyb00pt5	297	54	cells	cell	NNS
cord-016293-pyb00pt5	297	55	.	.	.
cord-016293-pyb00pt5	298	1	Ashanthi	Ashanthi	NNP
cord-016293-pyb00pt5	298	2	DeSilva	DeSilva	NNP
cord-016293-pyb00pt5	298	3	,	,	,
cord-016293-pyb00pt5	298	4	the	the	DT
cord-016293-pyb00pt5	298	5	girl	girl	NN
cord-016293-pyb00pt5	298	6	who	who	WP
cord-016293-pyb00pt5	298	7	received	receive	VBD
cord-016293-pyb00pt5	298	8	the	the	DT
cord-016293-pyb00pt5	298	9	first	first	JJ
cord-016293-pyb00pt5	298	10	credible	credible	JJ
cord-016293-pyb00pt5	298	11	gene	gene	NN
cord-016293-pyb00pt5	298	12	therapy	therapy	NN
cord-016293-pyb00pt5	298	13	,	,	,
cord-016293-pyb00pt5	298	14	continues	continue	VBZ
cord-016293-pyb00pt5	298	15	to	to	TO
cord-016293-pyb00pt5	298	16	do	do	VB
cord-016293-pyb00pt5	298	17	well	well	RB
cord-016293-pyb00pt5	298	18	more	more	JJR
cord-016293-pyb00pt5	298	19	than	than	IN
cord-016293-pyb00pt5	298	20	a	a	DT
cord-016293-pyb00pt5	298	21	decade	decade	NN
cord-016293-pyb00pt5	298	22	later	later	RB
cord-016293-pyb00pt5	298	23	.	.	.
cord-016293-pyb00pt5	299	1	Cynthia	Cynthia	NNP
cord-016293-pyb00pt5	299	2	Cutshall	Cutshall	NNP
cord-016293-pyb00pt5	299	3	,	,	,
cord-016293-pyb00pt5	299	4	the	the	DT
cord-016293-pyb00pt5	299	5	second	second	JJ
cord-016293-pyb00pt5	299	6	child	child	NN
cord-016293-pyb00pt5	299	7	to	to	TO
cord-016293-pyb00pt5	299	8	receive	receive	VB
cord-016293-pyb00pt5	299	9	gene	gene	NN
cord-016293-pyb00pt5	299	10	therapy	therapy	NN
cord-016293-pyb00pt5	299	11	for	for	IN
cord-016293-pyb00pt5	299	12	the	the	DT
cord-016293-pyb00pt5	299	13	same	same	JJ
cord-016293-pyb00pt5	299	14	disorder	disorder	NN
cord-016293-pyb00pt5	299	15	as	as	IN
cord-016293-pyb00pt5	299	16	DeSilva	DeSilva	NNP
cord-016293-pyb00pt5	299	17	,	,	,
cord-016293-pyb00pt5	299	18	also	also	RB
cord-016293-pyb00pt5	299	19	continues	continue	VBZ
cord-016293-pyb00pt5	299	20	to	to	TO
cord-016293-pyb00pt5	299	21	do	do	VB
cord-016293-pyb00pt5	299	22	well	well	RB
cord-016293-pyb00pt5	299	23	.	.	.
cord-016293-pyb00pt5	300	1	Within	within	IN
cord-016293-pyb00pt5	300	2	10	10	CD
cord-016293-pyb00pt5	300	3	years	year	NNS
cord-016293-pyb00pt5	300	4	(	(	-LRB-
cord-016293-pyb00pt5	300	5	by	by	IN
cord-016293-pyb00pt5	300	6	January	January	NNP
cord-016293-pyb00pt5	300	7	2000	2000	CD
cord-016293-pyb00pt5	300	8	)	)	-RRB-
cord-016293-pyb00pt5	300	9	,	,	,
cord-016293-pyb00pt5	300	10	more	more	JJR
cord-016293-pyb00pt5	300	11	than	than	IN
cord-016293-pyb00pt5	300	12	350	350	CD
cord-016293-pyb00pt5	300	13	gene	gene	NN
cord-016293-pyb00pt5	300	14	therapy	therapy	NN
cord-016293-pyb00pt5	300	15	protocols	protocol	NNS
cord-016293-pyb00pt5	300	16	had	have	VBD
cord-016293-pyb00pt5	300	17	been	be	VBN
cord-016293-pyb00pt5	300	18	approved	approve	VBN
cord-016293-pyb00pt5	300	19	in	in	IN
cord-016293-pyb00pt5	300	20	the	the	DT
cord-016293-pyb00pt5	300	21	US	US	NNP
cord-016293-pyb00pt5	300	22	and	and	CC
cord-016293-pyb00pt5	300	23	worldwide	worldwide	RB
cord-016293-pyb00pt5	300	24	,	,	,
cord-016293-pyb00pt5	300	25	researchers	researcher	NNS
cord-016293-pyb00pt5	300	26	launched	launch	VBD
cord-016293-pyb00pt5	300	27	more	more	JJR
cord-016293-pyb00pt5	300	28	than	than	IN
cord-016293-pyb00pt5	300	29	400	400	CD
cord-016293-pyb00pt5	300	30	clinical	clinical	JJ
cord-016293-pyb00pt5	300	31	trials	trial	NNS
cord-016293-pyb00pt5	300	32	to	to	TO
cord-016293-pyb00pt5	300	33	test	test	VB
cord-016293-pyb00pt5	300	34	gene	gene	NN
cord-016293-pyb00pt5	300	35	therapy	therapy	NN
cord-016293-pyb00pt5	300	36	against	against	IN
cord-016293-pyb00pt5	300	37	a	a	DT
cord-016293-pyb00pt5	300	38	wide	wide	JJ
cord-016293-pyb00pt5	300	39	array	array	NN
cord-016293-pyb00pt5	300	40	of	of	IN
cord-016293-pyb00pt5	300	41	illnesses	illness	NNS
cord-016293-pyb00pt5	300	42	.	.	.
cord-016293-pyb00pt5	301	1	Surprisingly	surprisingly	RB
cord-016293-pyb00pt5	301	2	,	,	,
cord-016293-pyb00pt5	301	3	a	a	DT
cord-016293-pyb00pt5	301	4	disease	disease	NN
cord-016293-pyb00pt5	301	5	not	not	RB
cord-016293-pyb00pt5	301	6	typically	typically	RB
cord-016293-pyb00pt5	301	7	heading	head	VBG
cord-016293-pyb00pt5	301	8	the	the	DT
cord-016293-pyb00pt5	301	9	charts	chart	NNS
cord-016293-pyb00pt5	301	10	of	of	IN
cord-016293-pyb00pt5	301	11	heritable	heritable	JJ
cord-016293-pyb00pt5	301	12	disorders	disorder	NNS
cord-016293-pyb00pt5	301	13	,	,	,
cord-016293-pyb00pt5	301	14	cancer	cancer	NN
cord-016293-pyb00pt5	301	15	has	have	VBZ
cord-016293-pyb00pt5	301	16	dominated	dominate	VBN
cord-016293-pyb00pt5	301	17	the	the	DT
cord-016293-pyb00pt5	301	18	research	research	NN
cord-016293-pyb00pt5	301	19	.	.	.
cord-016293-pyb00pt5	302	1	In	in	IN
cord-016293-pyb00pt5	302	2	1994	1994	CD
cord-016293-pyb00pt5	302	3	cancer	cancer	NN
cord-016293-pyb00pt5	302	4	patients	patient	NNS
cord-016293-pyb00pt5	302	5	were	be	VBD
cord-016293-pyb00pt5	302	6	treated	treat	VBN
cord-016293-pyb00pt5	302	7	with	with	IN
cord-016293-pyb00pt5	302	8	the	the	DT
cord-016293-pyb00pt5	302	9	tumor	tumor	NN
cord-016293-pyb00pt5	302	10	necrosis	necrosis	NN
cord-016293-pyb00pt5	302	11	factor	factor	NN
cord-016293-pyb00pt5	302	12	gene	gene	NN
cord-016293-pyb00pt5	302	13	,	,	,
cord-016293-pyb00pt5	302	14	a	a	DT
cord-016293-pyb00pt5	302	15	natural	natural	JJ
cord-016293-pyb00pt5	302	16	tumor	tumor	NN
cord-016293-pyb00pt5	302	17	fighting	fight	VBG
cord-016293-pyb00pt5	302	18	protein	protein	NN
cord-016293-pyb00pt5	302	19	which	which	WDT
cord-016293-pyb00pt5	302	20	worked	work	VBD
cord-016293-pyb00pt5	302	21	to	to	IN
cord-016293-pyb00pt5	302	22	a	a	DT
cord-016293-pyb00pt5	302	23	limited	limited	JJ
cord-016293-pyb00pt5	302	24	extent	extent	NN
cord-016293-pyb00pt5	302	25	.	.	.
cord-016293-pyb00pt5	303	1	Even	even	RB
cord-016293-pyb00pt5	303	2	more	more	RBR
cord-016293-pyb00pt5	303	3	surprisingly	surprisingly	RB
cord-016293-pyb00pt5	303	4	,	,	,
cord-016293-pyb00pt5	303	5	after	after	IN
cord-016293-pyb00pt5	303	6	the	the	DT
cord-016293-pyb00pt5	303	7	initial	initial	JJ
cord-016293-pyb00pt5	303	8	flurry	flurry	NN
cord-016293-pyb00pt5	303	9	of	of	IN
cord-016293-pyb00pt5	303	10	success	success	NN
cord-016293-pyb00pt5	303	11	little	little	JJ
cord-016293-pyb00pt5	303	12	has	have	VBZ
cord-016293-pyb00pt5	303	13	worked	work	VBN
cord-016293-pyb00pt5	303	14	.	.	.
cord-016293-pyb00pt5	304	1	Gene	gene	NN
cord-016293-pyb00pt5	304	2	therapy	therapy	NN
cord-016293-pyb00pt5	304	3	,	,	,
cord-016293-pyb00pt5	304	4	the	the	DT
cord-016293-pyb00pt5	304	5	promising	promising	JJ
cord-016293-pyb00pt5	304	6	miracle	miracle	NN
cord-016293-pyb00pt5	304	7	of	of	IN
cord-016293-pyb00pt5	304	8	1990	1990	CD
cord-016293-pyb00pt5	304	9	failed	fail	VBD
cord-016293-pyb00pt5	304	10	to	to	TO
cord-016293-pyb00pt5	304	11	deliver	deliver	VB
cord-016293-pyb00pt5	304	12	on	on	IN
cord-016293-pyb00pt5	304	13	its	-PRON-	PRP$
cord-016293-pyb00pt5	304	14	early	early	JJ
cord-016293-pyb00pt5	304	15	promise	promise	NN
cord-016293-pyb00pt5	304	16	over	over	IN
cord-016293-pyb00pt5	304	17	the	the	DT
cord-016293-pyb00pt5	304	18	decade	decade	NN
cord-016293-pyb00pt5	304	19	.	.	.
cord-016293-pyb00pt5	305	1	Apart	apart	RB
cord-016293-pyb00pt5	305	2	from	from	IN
cord-016293-pyb00pt5	305	3	those	those	DT
cord-016293-pyb00pt5	305	4	examples	example	NNS
cord-016293-pyb00pt5	305	5	,	,	,
cord-016293-pyb00pt5	305	6	there	there	EX
cord-016293-pyb00pt5	305	7	are	be	VBP
cord-016293-pyb00pt5	305	8	many	many	JJ
cord-016293-pyb00pt5	305	9	diseases	disease	NNS
cord-016293-pyb00pt5	305	10	whose	whose	WP$
cord-016293-pyb00pt5	305	11	molecular	molecular	JJ
cord-016293-pyb00pt5	305	12	pathology	pathology	NN
cord-016293-pyb00pt5	305	13	is	be	VBZ
cord-016293-pyb00pt5	305	14	,	,	,
cord-016293-pyb00pt5	305	15	or	or	CC
cord-016293-pyb00pt5	305	16	soon	soon	RB
cord-016293-pyb00pt5	305	17	will	will	MD
cord-016293-pyb00pt5	305	18	be	be	VB
cord-016293-pyb00pt5	305	19	,	,	,
cord-016293-pyb00pt5	305	20	well	well	RB
cord-016293-pyb00pt5	305	21	understood	understand	VBN
cord-016293-pyb00pt5	305	22	,	,	,
cord-016293-pyb00pt5	305	23	but	but	CC
cord-016293-pyb00pt5	305	24	for	for	IN
cord-016293-pyb00pt5	305	25	which	which	WDT
cord-016293-pyb00pt5	305	26	no	no	DT
cord-016293-pyb00pt5	305	27	satisfactory	satisfactory	JJ
cord-016293-pyb00pt5	305	28	treatments	treatment	NNS
cord-016293-pyb00pt5	305	29	have	have	VBP
cord-016293-pyb00pt5	305	30	yet	yet	RB
cord-016293-pyb00pt5	305	31	been	be	VBN
cord-016293-pyb00pt5	305	32	developed	develop	VBN
cord-016293-pyb00pt5	305	33	.	.	.
cord-016293-pyb00pt5	306	1	At	at	IN
cord-016293-pyb00pt5	306	2	the	the	DT
cord-016293-pyb00pt5	306	3	beginning	beginning	NN
cord-016293-pyb00pt5	306	4	of	of	IN
cord-016293-pyb00pt5	306	5	the	the	DT
cord-016293-pyb00pt5	306	6	nineties	ninety	NNS
cord-016293-pyb00pt5	306	7	it	-PRON-	PRP
cord-016293-pyb00pt5	306	8	appeared	appear	VBD
cord-016293-pyb00pt5	306	9	that	that	IN
cord-016293-pyb00pt5	306	10	gene	gene	NN
cord-016293-pyb00pt5	306	11	therapy	therapy	NN
cord-016293-pyb00pt5	306	12	did	do	VBD
cord-016293-pyb00pt5	306	13	offer	offer	VB
cord-016293-pyb00pt5	306	14	new	new	JJ
cord-016293-pyb00pt5	306	15	opportunities	opportunity	NNS
cord-016293-pyb00pt5	306	16	to	to	TO
cord-016293-pyb00pt5	306	17	treat	treat	VB
cord-016293-pyb00pt5	306	18	these	these	DT
cord-016293-pyb00pt5	306	19	disorders	disorder	NNS
cord-016293-pyb00pt5	306	20	both	both	DT
cord-016293-pyb00pt5	306	21	by	by	IN
cord-016293-pyb00pt5	306	22	restoring	restore	VBG
cord-016293-pyb00pt5	306	23	gene	gene	NN
cord-016293-pyb00pt5	306	24	functions	function	NNS
cord-016293-pyb00pt5	306	25	that	that	WDT
cord-016293-pyb00pt5	306	26	have	have	VBP
cord-016293-pyb00pt5	306	27	been	be	VBN
cord-016293-pyb00pt5	306	28	lost	lose	VBN
cord-016293-pyb00pt5	306	29	through	through	IN
cord-016293-pyb00pt5	306	30	mutation	mutation	NN
cord-016293-pyb00pt5	306	31	and	and	CC
cord-016293-pyb00pt5	306	32	by	by	IN
cord-016293-pyb00pt5	306	33	introducing	introduce	VBG
cord-016293-pyb00pt5	306	34	genes	gene	NNS
cord-016293-pyb00pt5	306	35	that	that	WDT
cord-016293-pyb00pt5	306	36	can	can	MD
cord-016293-pyb00pt5	306	37	inhibit	inhibit	VB
cord-016293-pyb00pt5	306	38	the	the	DT
cord-016293-pyb00pt5	306	39	replication	replication	NN
cord-016293-pyb00pt5	306	40	of	of	IN
cord-016293-pyb00pt5	306	41	infectious	infectious	JJ
cord-016293-pyb00pt5	306	42	agents	agent	NNS
cord-016293-pyb00pt5	306	43	,	,	,
cord-016293-pyb00pt5	306	44	render	render	VB
cord-016293-pyb00pt5	306	45	cells	cell	NNS
cord-016293-pyb00pt5	306	46	resistant	resistant	JJ
cord-016293-pyb00pt5	306	47	to	to	IN
cord-016293-pyb00pt5	306	48	cytotoxic	cytotoxic	JJ
cord-016293-pyb00pt5	306	49	drugs	drug	NNS
cord-016293-pyb00pt5	306	50	,	,	,
cord-016293-pyb00pt5	306	51	or	or	CC
cord-016293-pyb00pt5	306	52	cause	cause	VB
cord-016293-pyb00pt5	306	53	the	the	DT
cord-016293-pyb00pt5	306	54	elimination	elimination	NN
cord-016293-pyb00pt5	306	55	of	of	IN
cord-016293-pyb00pt5	306	56	aberrant	aberrant	JJ
cord-016293-pyb00pt5	306	57	cells	cell	NNS
cord-016293-pyb00pt5	306	58	.	.	.
cord-016293-pyb00pt5	307	1	From	from	IN
cord-016293-pyb00pt5	307	2	this	this	DT
cord-016293-pyb00pt5	307	3	"	"	``
cord-016293-pyb00pt5	307	4	genomic	genomic	JJ
cord-016293-pyb00pt5	307	5	"	"	''
cord-016293-pyb00pt5	307	6	viewpoint	viewpoint	NN
cord-016293-pyb00pt5	307	7	genes	gene	NNS
cord-016293-pyb00pt5	307	8	could	could	MD
cord-016293-pyb00pt5	307	9	be	be	VB
cord-016293-pyb00pt5	307	10	said	say	VBN
cord-016293-pyb00pt5	307	11	to	to	TO
cord-016293-pyb00pt5	307	12	be	be	VB
cord-016293-pyb00pt5	307	13	viewed	view	VBN
cord-016293-pyb00pt5	307	14	as	as	IN
cord-016293-pyb00pt5	307	15	medicines	medicine	NNS
cord-016293-pyb00pt5	307	16	,	,	,
cord-016293-pyb00pt5	307	17	and	and	CC
cord-016293-pyb00pt5	307	18	their	-PRON-	PRP$
cord-016293-pyb00pt5	307	19	development	development	NN
cord-016293-pyb00pt5	307	20	as	as	IN
cord-016293-pyb00pt5	307	21	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	307	22	should	should	MD
cord-016293-pyb00pt5	307	23	embrace	embrace	VB
cord-016293-pyb00pt5	307	24	the	the	DT
cord-016293-pyb00pt5	307	25	issues	issue	NNS
cord-016293-pyb00pt5	307	26	facing	face	VBG
cord-016293-pyb00pt5	307	27	the	the	DT
cord-016293-pyb00pt5	307	28	development	development	NN
cord-016293-pyb00pt5	307	29	of	of	IN
cord-016293-pyb00pt5	307	30	small	small	JJ
cord-016293-pyb00pt5	307	31	-	-	HYPH
cord-016293-pyb00pt5	307	32	molecule	molecule	NN
cord-016293-pyb00pt5	307	33	and	and	CC
cord-016293-pyb00pt5	307	34	protein	protein	NN
cord-016293-pyb00pt5	307	35	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	307	36	such	such	JJ
cord-016293-pyb00pt5	307	37	as	as	IN
cord-016293-pyb00pt5	307	38	bioavailability	bioavailability	NN
cord-016293-pyb00pt5	307	39	,	,	,
cord-016293-pyb00pt5	307	40	specificity	specificity	NN
cord-016293-pyb00pt5	307	41	,	,	,
cord-016293-pyb00pt5	307	42	toxicity	toxicity	NN
cord-016293-pyb00pt5	307	43	,	,	,
cord-016293-pyb00pt5	307	44	potency	potency	NN
cord-016293-pyb00pt5	307	45	,	,	,
cord-016293-pyb00pt5	307	46	and	and	CC
cord-016293-pyb00pt5	307	47	the	the	DT
cord-016293-pyb00pt5	307	48	ability	ability	NN
cord-016293-pyb00pt5	307	49	to	to	TO
cord-016293-pyb00pt5	307	50	be	be	VB
cord-016293-pyb00pt5	307	51	manufactured	manufacture	VBN
cord-016293-pyb00pt5	307	52	at	at	IN
cord-016293-pyb00pt5	307	53	large	large	JJ
cord-016293-pyb00pt5	307	54	scale	scale	NN
cord-016293-pyb00pt5	307	55	in	in	IN
cord-016293-pyb00pt5	307	56	a	a	DT
cord-016293-pyb00pt5	307	57	cost	cost	NN
cord-016293-pyb00pt5	307	58	-	-	HYPH
cord-016293-pyb00pt5	307	59	effective	effective	JJ
cord-016293-pyb00pt5	307	60	manner	manner	NN
cord-016293-pyb00pt5	307	61	.	.	.
cord-016293-pyb00pt5	308	1	Of	of	RB
cord-016293-pyb00pt5	308	2	course	course	RB
cord-016293-pyb00pt5	308	3	for	for	IN
cord-016293-pyb00pt5	308	4	such	such	PDT
cord-016293-pyb00pt5	308	5	a	a	DT
cord-016293-pyb00pt5	308	6	radical	radical	JJ
cord-016293-pyb00pt5	308	7	approach	approach	NN
cord-016293-pyb00pt5	308	8	certain	certain	JJ
cord-016293-pyb00pt5	308	9	basal	basal	JJ
cord-016293-pyb00pt5	308	10	level	level	NN
cord-016293-pyb00pt5	308	11	criteria	criterion	NNS
cord-016293-pyb00pt5	308	12	needed	need	VBN
cord-016293-pyb00pt5	308	13	to	to	TO
cord-016293-pyb00pt5	308	14	be	be	VB
cord-016293-pyb00pt5	308	15	established	establish	VBN
cord-016293-pyb00pt5	308	16	for	for	IN
cord-016293-pyb00pt5	308	17	selecting	select	VBG
cord-016293-pyb00pt5	308	18	disease	disease	NN
cord-016293-pyb00pt5	308	19	candidates	candidate	NNS
cord-016293-pyb00pt5	308	20	for	for	IN
cord-016293-pyb00pt5	308	21	human	human	JJ
cord-016293-pyb00pt5	308	22	gene	gene	NN
cord-016293-pyb00pt5	308	23	therapy	therapy	NN
cord-016293-pyb00pt5	308	24	.	.	.
cord-016293-pyb00pt5	309	1	These	these	DT
cord-016293-pyb00pt5	309	2	include	include	VBP
cord-016293-pyb00pt5	309	3	,	,	,
cord-016293-pyb00pt5	309	4	such	such	JJ
cord-016293-pyb00pt5	309	5	factors	factor	NNS
cord-016293-pyb00pt5	309	6	as	as	IN
cord-016293-pyb00pt5	309	7	the	the	DT
cord-016293-pyb00pt5	309	8	disease	disease	NN
cord-016293-pyb00pt5	309	9	is	be	VBZ
cord-016293-pyb00pt5	309	10	an	an	DT
cord-016293-pyb00pt5	309	11	incurable	incurable	JJ
cord-016293-pyb00pt5	309	12	,	,	,
cord-016293-pyb00pt5	309	13	life	life	NN
cord-016293-pyb00pt5	309	14	-	-	HYPH
cord-016293-pyb00pt5	309	15	threatening	threaten	VBG
cord-016293-pyb00pt5	309	16	disease	disease	NN
cord-016293-pyb00pt5	309	17	;	;	:
cord-016293-pyb00pt5	309	18	organ	organ	NN
cord-016293-pyb00pt5	309	19	,	,	,
cord-016293-pyb00pt5	309	20	tissue	tissue	NN
cord-016293-pyb00pt5	309	21	,	,	,
cord-016293-pyb00pt5	309	22	and	and	CC
cord-016293-pyb00pt5	309	23	cell	cell	NN
cord-016293-pyb00pt5	309	24	types	type	NNS
cord-016293-pyb00pt5	309	25	affected	affect	VBN
cord-016293-pyb00pt5	309	26	by	by	IN
cord-016293-pyb00pt5	309	27	the	the	DT
cord-016293-pyb00pt5	309	28	disease	disease	NN
cord-016293-pyb00pt5	309	29	have	have	VBP
cord-016293-pyb00pt5	309	30	been	be	VBN
cord-016293-pyb00pt5	309	31	identified	identify	VBN
cord-016293-pyb00pt5	309	32	;	;	:
cord-016293-pyb00pt5	309	33	the	the	DT
cord-016293-pyb00pt5	309	34	normal	normal	JJ
cord-016293-pyb00pt5	309	35	counterpart	counterpart	NN
cord-016293-pyb00pt5	309	36	of	of	IN
cord-016293-pyb00pt5	309	37	the	the	DT
cord-016293-pyb00pt5	309	38	defective	defective	JJ
cord-016293-pyb00pt5	309	39	gene	gene	NN
cord-016293-pyb00pt5	309	40	has	have	VBZ
cord-016293-pyb00pt5	309	41	been	be	VBN
cord-016293-pyb00pt5	309	42	isolated	isolate	VBN
cord-016293-pyb00pt5	309	43	and	and	CC
cord-016293-pyb00pt5	309	44	cloned	clone	VBN
cord-016293-pyb00pt5	309	45	;	;	:
cord-016293-pyb00pt5	309	46	either	either	CC
cord-016293-pyb00pt5	309	47	the	the	DT
cord-016293-pyb00pt5	309	48	normal	normal	JJ
cord-016293-pyb00pt5	309	49	gene	gene	NN
cord-016293-pyb00pt5	309	50	can	can	MD
cord-016293-pyb00pt5	309	51	be	be	VB
cord-016293-pyb00pt5	309	52	introduced	introduce	VBN
cord-016293-pyb00pt5	309	53	into	into	IN
cord-016293-pyb00pt5	309	54	a	a	DT
cord-016293-pyb00pt5	309	55	substantial	substantial	JJ
cord-016293-pyb00pt5	309	56	subfraction	subfraction	NN
cord-016293-pyb00pt5	309	57	of	of	IN
cord-016293-pyb00pt5	309	58	the	the	DT
cord-016293-pyb00pt5	309	59	cells	cell	NNS
cord-016293-pyb00pt5	309	60	from	from	IN
cord-016293-pyb00pt5	309	61	the	the	DT
cord-016293-pyb00pt5	309	62	affected	affect	VBN
cord-016293-pyb00pt5	309	63	tissue	tissue	NN
cord-016293-pyb00pt5	309	64	,	,	,
cord-016293-pyb00pt5	309	65	or	or	CC
cord-016293-pyb00pt5	309	66	the	the	DT
cord-016293-pyb00pt5	309	67	introduction	introduction	NN
cord-016293-pyb00pt5	309	68	of	of	IN
cord-016293-pyb00pt5	309	69	the	the	DT
cord-016293-pyb00pt5	309	70	gene	gene	NN
cord-016293-pyb00pt5	309	71	into	into	IN
cord-016293-pyb00pt5	309	72	the	the	DT
cord-016293-pyb00pt5	309	73	available	available	JJ
cord-016293-pyb00pt5	309	74	target	target	NN
cord-016293-pyb00pt5	309	75	tissue	tissue	NN
cord-016293-pyb00pt5	309	76	,	,	,
cord-016293-pyb00pt5	309	77	such	such	JJ
cord-016293-pyb00pt5	309	78	as	as	IN
cord-016293-pyb00pt5	309	79	bone	bone	NN
cord-016293-pyb00pt5	309	80	marrow	marrow	NN
cord-016293-pyb00pt5	309	81	,	,	,
cord-016293-pyb00pt5	309	82	will	will	MD
cord-016293-pyb00pt5	309	83	somehow	somehow	RB
cord-016293-pyb00pt5	309	84	alter	alter	VB
cord-016293-pyb00pt5	309	85	the	the	DT
cord-016293-pyb00pt5	309	86	disease	disease	NN
cord-016293-pyb00pt5	309	87	process	process	NN
cord-016293-pyb00pt5	309	88	in	in	IN
cord-016293-pyb00pt5	309	89	the	the	DT
cord-016293-pyb00pt5	309	90	tissue	tissue	NN
cord-016293-pyb00pt5	309	91	affected	affect	VBN
cord-016293-pyb00pt5	309	92	by	by	IN
cord-016293-pyb00pt5	309	93	the	the	DT
cord-016293-pyb00pt5	309	94	disease	disease	NN
cord-016293-pyb00pt5	309	95	;	;	:
cord-016293-pyb00pt5	309	96	the	the	DT
cord-016293-pyb00pt5	309	97	gene	gene	NN
cord-016293-pyb00pt5	309	98	can	can	MD
cord-016293-pyb00pt5	309	99	be	be	VB
cord-016293-pyb00pt5	309	100	expressed	express	VBN
cord-016293-pyb00pt5	309	101	adequately	adequately	RB
cord-016293-pyb00pt5	310	1	(	(	-LRB-
cord-016293-pyb00pt5	310	2	it	-PRON-	PRP
cord-016293-pyb00pt5	310	3	will	will	MD
cord-016293-pyb00pt5	310	4	direct	direct	VB
cord-016293-pyb00pt5	310	5	the	the	DT
cord-016293-pyb00pt5	310	6	production	production	NN
cord-016293-pyb00pt5	310	7	of	of	IN
cord-016293-pyb00pt5	310	8	enough	enough	JJ
cord-016293-pyb00pt5	310	9	normal	normal	JJ
cord-016293-pyb00pt5	310	10	protein	protein	NN
cord-016293-pyb00pt5	310	11	to	to	TO
cord-016293-pyb00pt5	310	12	make	make	VB
cord-016293-pyb00pt5	310	13	a	a	DT
cord-016293-pyb00pt5	310	14	difference	difference	NN
cord-016293-pyb00pt5	310	15	)	)	-RRB-
cord-016293-pyb00pt5	310	16	;	;	:
cord-016293-pyb00pt5	310	17	and	and	CC
cord-016293-pyb00pt5	310	18	techniques	technique	NNS
cord-016293-pyb00pt5	310	19	are	be	VBP
cord-016293-pyb00pt5	310	20	available	available	JJ
cord-016293-pyb00pt5	310	21	to	to	TO
cord-016293-pyb00pt5	310	22	verify	verify	VB
cord-016293-pyb00pt5	310	23	the	the	DT
cord-016293-pyb00pt5	310	24	safety	safety	NN
cord-016293-pyb00pt5	310	25	of	of	IN
cord-016293-pyb00pt5	310	26	the	the	DT
cord-016293-pyb00pt5	310	27	procedure	procedure	NN
cord-016293-pyb00pt5	310	28	.	.	.
cord-016293-pyb00pt5	311	1	An	an	DT
cord-016293-pyb00pt5	311	2	ideal	ideal	JJ
cord-016293-pyb00pt5	311	3	gene	gene	NN
cord-016293-pyb00pt5	311	4	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	311	5	should	should	MD
cord-016293-pyb00pt5	311	6	,	,	,
cord-016293-pyb00pt5	311	7	therefore	therefore	RB
cord-016293-pyb00pt5	311	8	,	,	,
cord-016293-pyb00pt5	311	9	be	be	VB
cord-016293-pyb00pt5	311	10	stably	stably	RB
cord-016293-pyb00pt5	311	11	formulated	formulate	VBN
cord-016293-pyb00pt5	311	12	at	at	IN
cord-016293-pyb00pt5	311	13	room	room	NN
cord-016293-pyb00pt5	311	14	temperature	temperature	NN
cord-016293-pyb00pt5	311	15	and	and	CC
cord-016293-pyb00pt5	311	16	amenable	amenable	JJ
cord-016293-pyb00pt5	311	17	to	to	IN
cord-016293-pyb00pt5	311	18	administration	administration	NN
cord-016293-pyb00pt5	311	19	either	either	CC
cord-016293-pyb00pt5	311	20	as	as	IN
cord-016293-pyb00pt5	311	21	an	an	DT
cord-016293-pyb00pt5	311	22	injectable	injectable	JJ
cord-016293-pyb00pt5	311	23	or	or	CC
cord-016293-pyb00pt5	311	24	aerosol	aerosol	NN
cord-016293-pyb00pt5	311	25	or	or	CC
cord-016293-pyb00pt5	311	26	by	by	IN
cord-016293-pyb00pt5	311	27	oral	oral	JJ
cord-016293-pyb00pt5	311	28	delivery	delivery	NN
cord-016293-pyb00pt5	311	29	in	in	IN
cord-016293-pyb00pt5	311	30	liquid	liquid	NN
cord-016293-pyb00pt5	311	31	or	or	CC
cord-016293-pyb00pt5	311	32	capsule	capsule	NN
cord-016293-pyb00pt5	311	33	form	form	NN
cord-016293-pyb00pt5	311	34	.	.	.
cord-016293-pyb00pt5	312	1	The	the	DT
cord-016293-pyb00pt5	312	2	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	312	3	should	should	MD
cord-016293-pyb00pt5	312	4	also	also	RB
cord-016293-pyb00pt5	312	5	be	be	VB
cord-016293-pyb00pt5	312	6	suitable	suitable	JJ
cord-016293-pyb00pt5	312	7	for	for	IN
cord-016293-pyb00pt5	312	8	repeat	repeat	NN
cord-016293-pyb00pt5	312	9	therapy	therapy	NN
cord-016293-pyb00pt5	312	10	,	,	,
cord-016293-pyb00pt5	312	11	and	and	CC
cord-016293-pyb00pt5	312	12	when	when	WRB
cord-016293-pyb00pt5	312	13	delivered	deliver	VBN
cord-016293-pyb00pt5	312	14	,	,	,
cord-016293-pyb00pt5	312	15	it	-PRON-	PRP
cord-016293-pyb00pt5	312	16	should	should	MD
cord-016293-pyb00pt5	312	17	neither	neither	CC
cord-016293-pyb00pt5	312	18	generate	generate	VB
cord-016293-pyb00pt5	312	19	an	an	DT
cord-016293-pyb00pt5	312	20	immune	immune	JJ
cord-016293-pyb00pt5	312	21	response	response	NN
cord-016293-pyb00pt5	312	22	nor	nor	CC
cord-016293-pyb00pt5	312	23	be	be	VB
cord-016293-pyb00pt5	312	24	destroyed	destroy	VBN
cord-016293-pyb00pt5	312	25	by	by	IN
cord-016293-pyb00pt5	312	26	tissue	tissue	NN
cord-016293-pyb00pt5	312	27	-	-	HYPH
cord-016293-pyb00pt5	312	28	scavenging	scavenging	NN
cord-016293-pyb00pt5	312	29	mechanisms	mechanism	NNS
cord-016293-pyb00pt5	312	30	.	.	.
cord-016293-pyb00pt5	313	1	When	when	WRB
cord-016293-pyb00pt5	313	2	delivered	deliver	VBN
cord-016293-pyb00pt5	313	3	to	to	IN
cord-016293-pyb00pt5	313	4	the	the	DT
cord-016293-pyb00pt5	313	5	target	target	NN
cord-016293-pyb00pt5	313	6	cell	cell	NN
cord-016293-pyb00pt5	313	7	,	,	,
cord-016293-pyb00pt5	313	8	the	the	DT
cord-016293-pyb00pt5	313	9	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	313	10	gene	gene	NN
cord-016293-pyb00pt5	313	11	should	should	MD
cord-016293-pyb00pt5	313	12	then	then	RB
cord-016293-pyb00pt5	313	13	be	be	VB
cord-016293-pyb00pt5	313	14	transported	transport	VBN
cord-016293-pyb00pt5	313	15	to	to	IN
cord-016293-pyb00pt5	313	16	the	the	DT
cord-016293-pyb00pt5	313	17	nucleus	nucleus	NN
cord-016293-pyb00pt5	313	18	,	,	,
cord-016293-pyb00pt5	313	19	where	where	WRB
cord-016293-pyb00pt5	313	20	it	-PRON-	PRP
cord-016293-pyb00pt5	313	21	should	should	MD
cord-016293-pyb00pt5	313	22	be	be	VB
cord-016293-pyb00pt5	313	23	maintained	maintain	VBN
cord-016293-pyb00pt5	313	24	as	as	IN
cord-016293-pyb00pt5	313	25	a	a	DT
cord-016293-pyb00pt5	313	26	stable	stable	JJ
cord-016293-pyb00pt5	313	27	plasmid	plasmid	NN
cord-016293-pyb00pt5	313	28	or	or	CC
cord-016293-pyb00pt5	313	29	chromosomal	chromosomal	JJ
cord-016293-pyb00pt5	313	30	integrant	integrant	NN
cord-016293-pyb00pt5	313	31	,	,	,
cord-016293-pyb00pt5	313	32	and	and	CC
cord-016293-pyb00pt5	313	33	be	be	VB
cord-016293-pyb00pt5	313	34	expressed	express	VBN
cord-016293-pyb00pt5	313	35	in	in	IN
cord-016293-pyb00pt5	313	36	a	a	DT
cord-016293-pyb00pt5	313	37	predictable	predictable	JJ
cord-016293-pyb00pt5	313	38	,	,	,
cord-016293-pyb00pt5	313	39	controlled	controlled	JJ
cord-016293-pyb00pt5	313	40	fashion	fashion	NN
cord-016293-pyb00pt5	313	41	at	at	IN
cord-016293-pyb00pt5	313	42	the	the	DT
cord-016293-pyb00pt5	313	43	desired	desire	VBN
cord-016293-pyb00pt5	313	44	potency	potency	NN
cord-016293-pyb00pt5	313	45	in	in	IN
cord-016293-pyb00pt5	313	46	a	a	DT
cord-016293-pyb00pt5	313	47	cell	cell	NN
cord-016293-pyb00pt5	313	48	-	-	HYPH
cord-016293-pyb00pt5	313	49	specific	specific	JJ
cord-016293-pyb00pt5	313	50	or	or	CC
cord-016293-pyb00pt5	313	51	tissue	tissue	NN
cord-016293-pyb00pt5	313	52	-	-	HYPH
cord-016293-pyb00pt5	313	53	specific	specific	JJ
cord-016293-pyb00pt5	313	54	manner	manner	NN
cord-016293-pyb00pt5	313	55	.	.	.
cord-016293-pyb00pt5	314	1	In	in	IN
cord-016293-pyb00pt5	314	2	addition	addition	NN
cord-016293-pyb00pt5	314	3	to	to	IN
cord-016293-pyb00pt5	314	4	the	the	DT
cord-016293-pyb00pt5	314	5	ADA	ADA	NNP
cord-016293-pyb00pt5	314	6	gene	gene	NN
cord-016293-pyb00pt5	314	7	transfer	transfer	NN
cord-016293-pyb00pt5	314	8	in	in	IN
cord-016293-pyb00pt5	314	9	children	child	NNS
cord-016293-pyb00pt5	314	10	with	with	IN
cord-016293-pyb00pt5	314	11	severe	severe	JJ
cord-016293-pyb00pt5	314	12	combined	combine	VBN
cord-016293-pyb00pt5	314	13	immunodeficiency	immunodeficiency	NN
cord-016293-pyb00pt5	314	14	syndrome	syndrome	NN
cord-016293-pyb00pt5	314	15	,	,	,
cord-016293-pyb00pt5	314	16	a	a	DT
cord-016293-pyb00pt5	314	17	gene	gene	NN
cord-016293-pyb00pt5	314	18	-	-	HYPH
cord-016293-pyb00pt5	314	19	marking	mark	VBG
cord-016293-pyb00pt5	314	20	study	study	NN
cord-016293-pyb00pt5	314	21	of	of	IN
cord-016293-pyb00pt5	314	22	Epstein	Epstein	NNP
cord-016293-pyb00pt5	314	23	-	-	HYPH
cord-016293-pyb00pt5	314	24	Barr	Barr	NNP
cord-016293-pyb00pt5	314	25	virus	virus	NN
cord-016293-pyb00pt5	314	26	-	-	HYPH
cord-016293-pyb00pt5	314	27	specific	specific	JJ
cord-016293-pyb00pt5	314	28	cytotoxic	cytotoxic	JJ
cord-016293-pyb00pt5	314	29	T	t	NN
cord-016293-pyb00pt5	314	30	cells	cell	NNS
cord-016293-pyb00pt5	314	31	,	,	,
cord-016293-pyb00pt5	314	32	and	and	CC
cord-016293-pyb00pt5	314	33	trials	trial	NNS
cord-016293-pyb00pt5	314	34	of	of	IN
cord-016293-pyb00pt5	314	35	gene	gene	NN
cord-016293-pyb00pt5	314	36	-	-	HYPH
cord-016293-pyb00pt5	314	37	modified	modify	VBN
cord-016293-pyb00pt5	314	38	T	T	NNP
cord-016293-pyb00pt5	314	39	cells	cell	NNS
cord-016293-pyb00pt5	314	40	expressing	express	VBG
cord-016293-pyb00pt5	314	41	suicide	suicide	NN
cord-016293-pyb00pt5	314	42	or	or	CC
cord-016293-pyb00pt5	314	43	viral	viral	JJ
cord-016293-pyb00pt5	314	44	resistance	resistance	NN
cord-016293-pyb00pt5	314	45	genes	gene	NNS
cord-016293-pyb00pt5	314	46	in	in	IN
cord-016293-pyb00pt5	314	47	patients	patient	NNS
cord-016293-pyb00pt5	314	48	infected	infect	VBN
cord-016293-pyb00pt5	314	49	with	with	IN
cord-016293-pyb00pt5	314	50	HIV	HIV	NNP
cord-016293-pyb00pt5	314	51	were	be	VBD
cord-016293-pyb00pt5	314	52	studied	study	VBN
cord-016293-pyb00pt5	314	53	in	in	IN
cord-016293-pyb00pt5	314	54	the	the	DT
cord-016293-pyb00pt5	314	55	early	early	JJ
cord-016293-pyb00pt5	314	56	nineties	ninety	NNS
cord-016293-pyb00pt5	314	57	.	.	.
cord-016293-pyb00pt5	315	1	Additional	additional	JJ
cord-016293-pyb00pt5	315	2	strategies	strategy	NNS
cord-016293-pyb00pt5	315	3	for	for	IN
cord-016293-pyb00pt5	315	4	T	t	NN
cord-016293-pyb00pt5	315	5	-	-	HYPH
cord-016293-pyb00pt5	315	6	cell	cell	NN
cord-016293-pyb00pt5	315	7	gene	gene	NN
cord-016293-pyb00pt5	315	8	therapy	therapy	NN
cord-016293-pyb00pt5	315	9	which	which	WDT
cord-016293-pyb00pt5	315	10	were	be	VBD
cord-016293-pyb00pt5	315	11	pursued	pursue	VBN
cord-016293-pyb00pt5	315	12	later	later	RB
cord-016293-pyb00pt5	315	13	in	in	IN
cord-016293-pyb00pt5	315	14	the	the	DT
cord-016293-pyb00pt5	315	15	decade	decade	NN
cord-016293-pyb00pt5	315	16	involve	involve	VBP
cord-016293-pyb00pt5	315	17	the	the	DT
cord-016293-pyb00pt5	315	18	engineering	engineering	NN
cord-016293-pyb00pt5	315	19	of	of	IN
cord-016293-pyb00pt5	315	20	novel	novel	JJ
cord-016293-pyb00pt5	315	21	T	t	NN
cord-016293-pyb00pt5	315	22	-	-	HYPH
cord-016293-pyb00pt5	315	23	cell	cell	NN
cord-016293-pyb00pt5	315	24	receptors	receptor	NNS
cord-016293-pyb00pt5	315	25	that	that	WDT
cord-016293-pyb00pt5	315	26	impart	impart	VBP
cord-016293-pyb00pt5	315	27	antigen	antigen	NN
cord-016293-pyb00pt5	315	28	specificity	specificity	NN
cord-016293-pyb00pt5	315	29	for	for	IN
cord-016293-pyb00pt5	315	30	virally	virally	RB
cord-016293-pyb00pt5	315	31	infected	infect	VBN
cord-016293-pyb00pt5	315	32	or	or	CC
cord-016293-pyb00pt5	315	33	malignant	malignant	JJ
cord-016293-pyb00pt5	315	34	cells	cell	NNS
cord-016293-pyb00pt5	315	35	.	.	.
cord-016293-pyb00pt5	316	1	Issues	issue	NNS
cord-016293-pyb00pt5	316	2	which	which	WDT
cord-016293-pyb00pt5	316	3	still	still	RB
cord-016293-pyb00pt5	316	4	are	be	VBP
cord-016293-pyb00pt5	316	5	not	not	RB
cord-016293-pyb00pt5	316	6	resolved	resolve	VBN
cord-016293-pyb00pt5	316	7	include	include	VBP
cord-016293-pyb00pt5	316	8	nuclear	nuclear	JJ
cord-016293-pyb00pt5	316	9	transport	transport	NN
cord-016293-pyb00pt5	316	10	,	,	,
cord-016293-pyb00pt5	316	11	integration	integration	NN
cord-016293-pyb00pt5	316	12	,	,	,
cord-016293-pyb00pt5	316	13	regulated	regulated	JJ
cord-016293-pyb00pt5	316	14	gene	gene	NN
cord-016293-pyb00pt5	316	15	expression	expression	NN
cord-016293-pyb00pt5	316	16	and	and	CC
cord-016293-pyb00pt5	316	17	immune	immune	JJ
cord-016293-pyb00pt5	316	18	surveillance	surveillance	NN
cord-016293-pyb00pt5	316	19	.	.	.
cord-016293-pyb00pt5	317	1	This	this	DT
cord-016293-pyb00pt5	317	2	knowledge	knowledge	NN
cord-016293-pyb00pt5	317	3	,	,	,
cord-016293-pyb00pt5	317	4	when	when	WRB
cord-016293-pyb00pt5	317	5	finally	finally	RB
cord-016293-pyb00pt5	317	6	understood	understand	VBD
cord-016293-pyb00pt5	317	7	and	and	CC
cord-016293-pyb00pt5	317	8	applied	apply	VBN
cord-016293-pyb00pt5	317	9	to	to	IN
cord-016293-pyb00pt5	317	10	the	the	DT
cord-016293-pyb00pt5	317	11	design	design	NN
cord-016293-pyb00pt5	317	12	of	of	IN
cord-016293-pyb00pt5	317	13	delivery	delivery	NN
cord-016293-pyb00pt5	317	14	vehicles	vehicle	NNS
cord-016293-pyb00pt5	317	15	of	of	IN
cord-016293-pyb00pt5	317	16	either	either	DT
cord-016293-pyb00pt5	317	17	viral	viral	JJ
cord-016293-pyb00pt5	317	18	or	or	CC
cord-016293-pyb00pt5	317	19	non	non	JJ
cord-016293-pyb00pt5	317	20	-	-	JJ
cord-016293-pyb00pt5	317	21	viral	viral	JJ
cord-016293-pyb00pt5	317	22	origin	origin	NN
cord-016293-pyb00pt5	317	23	,	,	,
cord-016293-pyb00pt5	317	24	will	will	MD
cord-016293-pyb00pt5	317	25	assist	assist	VB
cord-016293-pyb00pt5	317	26	in	in	IN
cord-016293-pyb00pt5	317	27	the	the	DT
cord-016293-pyb00pt5	317	28	realization	realization	NN
cord-016293-pyb00pt5	317	29	of	of	IN
cord-016293-pyb00pt5	317	30	gene	gene	NN
cord-016293-pyb00pt5	317	31	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	317	32	as	as	IN
cord-016293-pyb00pt5	317	33	safe	safe	JJ
cord-016293-pyb00pt5	317	34	and	and	CC
cord-016293-pyb00pt5	317	35	beneficial	beneficial	JJ
cord-016293-pyb00pt5	317	36	medicines	medicine	NNS
cord-016293-pyb00pt5	317	37	that	that	WDT
cord-016293-pyb00pt5	317	38	are	be	VBP
cord-016293-pyb00pt5	317	39	suited	suit	VBN
cord-016293-pyb00pt5	317	40	to	to	IN
cord-016293-pyb00pt5	317	41	the	the	DT
cord-016293-pyb00pt5	317	42	routine	routine	JJ
cord-016293-pyb00pt5	317	43	management	management	NN
cord-016293-pyb00pt5	317	44	of	of	IN
cord-016293-pyb00pt5	317	45	human	human	JJ
cord-016293-pyb00pt5	317	46	health	health	NN
cord-016293-pyb00pt5	317	47	.	.	.
cord-016293-pyb00pt5	318	1	Scientists	scientist	NNS
cord-016293-pyb00pt5	318	2	are	be	VBP
cord-016293-pyb00pt5	318	3	also	also	RB
cord-016293-pyb00pt5	318	4	working	work	VBG
cord-016293-pyb00pt5	318	5	on	on	IN
cord-016293-pyb00pt5	318	6	using	use	VBG
cord-016293-pyb00pt5	318	7	gene	gene	NN
cord-016293-pyb00pt5	318	8	therapy	therapy	NN
cord-016293-pyb00pt5	318	9	to	to	TO
cord-016293-pyb00pt5	318	10	generate	generate	VB
cord-016293-pyb00pt5	318	11	antibodies	antibody	NNS
cord-016293-pyb00pt5	318	12	directly	directly	RB
cord-016293-pyb00pt5	318	13	inside	inside	IN
cord-016293-pyb00pt5	318	14	cells	cell	NNS
cord-016293-pyb00pt5	318	15	to	to	TO
cord-016293-pyb00pt5	318	16	block	block	VB
cord-016293-pyb00pt5	318	17	the	the	DT
cord-016293-pyb00pt5	318	18	production	production	NN
cord-016293-pyb00pt5	318	19	of	of	IN
cord-016293-pyb00pt5	318	20	harmful	harmful	JJ
cord-016293-pyb00pt5	318	21	viruses	virus	NNS
cord-016293-pyb00pt5	318	22	such	such	JJ
cord-016293-pyb00pt5	318	23	as	as	IN
cord-016293-pyb00pt5	318	24	HIV	HIV	NNP
cord-016293-pyb00pt5	318	25	or	or	CC
cord-016293-pyb00pt5	318	26	even	even	RB
cord-016293-pyb00pt5	318	27	cancer	cancer	NN
cord-016293-pyb00pt5	318	28	-	-	HYPH
cord-016293-pyb00pt5	318	29	inducing	induce	VBG
cord-016293-pyb00pt5	318	30	proteins	protein	NNS
cord-016293-pyb00pt5	318	31	.	.	.
cord-016293-pyb00pt5	319	1	There	there	EX
cord-016293-pyb00pt5	319	2	is	be	VBZ
cord-016293-pyb00pt5	319	3	a	a	DT
cord-016293-pyb00pt5	319	4	specific	specific	JJ
cord-016293-pyb00pt5	319	5	connection	connection	NN
cord-016293-pyb00pt5	319	6	with	with	IN
cord-016293-pyb00pt5	319	7	Francis	Francis	NNP
cord-016293-pyb00pt5	319	8	Collins	Collins	NNP
cord-016293-pyb00pt5	319	9	,	,	,
cord-016293-pyb00pt5	319	10	as	as	IN
cord-016293-pyb00pt5	319	11	his	-PRON-	PRP$
cord-016293-pyb00pt5	319	12	motivation	motivation	NN
cord-016293-pyb00pt5	319	13	for	for	IN
cord-016293-pyb00pt5	319	14	pursuing	pursue	VBG
cord-016293-pyb00pt5	319	15	the	the	DT
cord-016293-pyb00pt5	319	16	HGP	HGP	NNP
cord-016293-pyb00pt5	319	17	was	be	VBD
cord-016293-pyb00pt5	319	18	his	-PRON-	PRP$
cord-016293-pyb00pt5	319	19	pursuit	pursuit	NN
cord-016293-pyb00pt5	319	20	of	of	IN
cord-016293-pyb00pt5	319	21	defective	defective	JJ
cord-016293-pyb00pt5	319	22	genes	gene	NNS
cord-016293-pyb00pt5	319	23	beginning	begin	VBG
cord-016293-pyb00pt5	319	24	with	with	IN
cord-016293-pyb00pt5	319	25	the	the	DT
cord-016293-pyb00pt5	319	26	cystic	cystic	JJ
cord-016293-pyb00pt5	319	27	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	319	28	gene	gene	NN
cord-016293-pyb00pt5	319	29	.	.	.
cord-016293-pyb00pt5	320	1	This	this	DT
cord-016293-pyb00pt5	320	2	gene	gene	NN
cord-016293-pyb00pt5	320	3	,	,	,
cord-016293-pyb00pt5	320	4	called	call	VBD
cord-016293-pyb00pt5	320	5	the	the	DT
cord-016293-pyb00pt5	320	6	CF	CF	NNP
cord-016293-pyb00pt5	320	7	transmembrane	transmembrane	NN
cord-016293-pyb00pt5	320	8	conductance	conductance	NN
cord-016293-pyb00pt5	320	9	regulator	regulator	NN
cord-016293-pyb00pt5	320	10	,	,	,
cord-016293-pyb00pt5	320	11	codes	code	NNS
cord-016293-pyb00pt5	320	12	for	for	IN
cord-016293-pyb00pt5	320	13	an	an	DT
cord-016293-pyb00pt5	320	14	ion	ion	NN
cord-016293-pyb00pt5	320	15	channel	channel	NN
cord-016293-pyb00pt5	320	16	protein	protein	NN
cord-016293-pyb00pt5	320	17	that	that	WDT
cord-016293-pyb00pt5	320	18	regulates	regulate	VBZ
cord-016293-pyb00pt5	320	19	salts	salt	NNS
cord-016293-pyb00pt5	320	20	in	in	IN
cord-016293-pyb00pt5	320	21	the	the	DT
cord-016293-pyb00pt5	320	22	lung	lung	NN
cord-016293-pyb00pt5	320	23	tissue	tissue	NN
cord-016293-pyb00pt5	320	24	.	.	.
cord-016293-pyb00pt5	321	1	The	the	DT
cord-016293-pyb00pt5	321	2	faulty	faulty	JJ
cord-016293-pyb00pt5	321	3	gene	gene	NN
cord-016293-pyb00pt5	321	4	prevents	prevent	VBZ
cord-016293-pyb00pt5	321	5	cells	cell	NNS
cord-016293-pyb00pt5	321	6	from	from	IN
cord-016293-pyb00pt5	321	7	excreting	excrete	VBG
cord-016293-pyb00pt5	321	8	salt	salt	NN
cord-016293-pyb00pt5	321	9	properly	properly	RB
cord-016293-pyb00pt5	321	10	causing	cause	VBG
cord-016293-pyb00pt5	321	11	a	a	DT
cord-016293-pyb00pt5	321	12	thick	thick	JJ
cord-016293-pyb00pt5	321	13	sticky	sticky	JJ
cord-016293-pyb00pt5	321	14	mucus	mucus	NN
cord-016293-pyb00pt5	321	15	to	to	TO
cord-016293-pyb00pt5	321	16	build	build	VB
cord-016293-pyb00pt5	321	17	up	up	RP
cord-016293-pyb00pt5	321	18	and	and	CC
cord-016293-pyb00pt5	321	19	destroy	destroy	VB
cord-016293-pyb00pt5	321	20	lung	lung	NN
cord-016293-pyb00pt5	321	21	tissue	tissue	NN
cord-016293-pyb00pt5	321	22	.	.	.
cord-016293-pyb00pt5	322	1	Scientists	scientist	NNS
cord-016293-pyb00pt5	322	2	have	have	VBP
cord-016293-pyb00pt5	322	3	spliced	splice	VBN
cord-016293-pyb00pt5	322	4	copies	copy	NNS
cord-016293-pyb00pt5	322	5	of	of	IN
cord-016293-pyb00pt5	322	6	the	the	DT
cord-016293-pyb00pt5	322	7	normal	normal	JJ
cord-016293-pyb00pt5	322	8	genes	gene	NNS
cord-016293-pyb00pt5	322	9	into	into	IN
cord-016293-pyb00pt5	322	10	disabled	disabled	JJ
cord-016293-pyb00pt5	322	11	adeno	adeno	NN
cord-016293-pyb00pt5	322	12	viruses	virus	NNS
cord-016293-pyb00pt5	322	13	that	that	WDT
cord-016293-pyb00pt5	322	14	target	target	VBP
cord-016293-pyb00pt5	322	15	lung	lung	NN
cord-016293-pyb00pt5	322	16	tissues	tissue	NNS
cord-016293-pyb00pt5	322	17	and	and	CC
cord-016293-pyb00pt5	322	18	have	have	VBP
cord-016293-pyb00pt5	322	19	used	use	VBN
cord-016293-pyb00pt5	322	20	bronchioscopes	bronchioscope	NNS
cord-016293-pyb00pt5	322	21	to	to	TO
cord-016293-pyb00pt5	322	22	deliver	deliver	VB
cord-016293-pyb00pt5	322	23	them	-PRON-	PRP
cord-016293-pyb00pt5	322	24	to	to	IN
cord-016293-pyb00pt5	322	25	the	the	DT
cord-016293-pyb00pt5	322	26	lungs	lung	NNS
cord-016293-pyb00pt5	322	27	.	.	.
cord-016293-pyb00pt5	323	1	The	the	DT
cord-016293-pyb00pt5	323	2	procedure	procedure	NN
cord-016293-pyb00pt5	323	3	worked	work	VBD
cord-016293-pyb00pt5	323	4	well	well	RB
cord-016293-pyb00pt5	323	5	in	in	IN
cord-016293-pyb00pt5	323	6	animal	animal	NN
cord-016293-pyb00pt5	323	7	studies	study	NNS
cord-016293-pyb00pt5	323	8	however	however	RB
cord-016293-pyb00pt5	323	9	clinical	clinical	JJ
cord-016293-pyb00pt5	323	10	trials	trial	NNS
cord-016293-pyb00pt5	323	11	in	in	IN
cord-016293-pyb00pt5	323	12	humans	human	NNS
cord-016293-pyb00pt5	323	13	were	be	VBD
cord-016293-pyb00pt5	323	14	not	not	RB
cord-016293-pyb00pt5	323	15	an	an	DT
cord-016293-pyb00pt5	323	16	unmitigated	unmitigated	JJ
cord-016293-pyb00pt5	323	17	success	success	NN
cord-016293-pyb00pt5	323	18	.	.	.
cord-016293-pyb00pt5	324	1	Because	because	IN
cord-016293-pyb00pt5	324	2	the	the	DT
cord-016293-pyb00pt5	324	3	cells	cell	NNS
cord-016293-pyb00pt5	324	4	lining	line	VBG
cord-016293-pyb00pt5	324	5	the	the	DT
cord-016293-pyb00pt5	324	6	lungs	lung	NNS
cord-016293-pyb00pt5	324	7	are	be	VBP
cord-016293-pyb00pt5	324	8	continuously	continuously	RB
cord-016293-pyb00pt5	324	9	being	be	VBG
cord-016293-pyb00pt5	324	10	replaced	replace	VBN
cord-016293-pyb00pt5	324	11	the	the	DT
cord-016293-pyb00pt5	324	12	effect	effect	NN
cord-016293-pyb00pt5	324	13	is	be	VBZ
cord-016293-pyb00pt5	324	14	not	not	RB
cord-016293-pyb00pt5	324	15	permanent	permanent	JJ
cord-016293-pyb00pt5	324	16	and	and	CC
cord-016293-pyb00pt5	324	17	must	must	MD
cord-016293-pyb00pt5	324	18	be	be	VB
cord-016293-pyb00pt5	324	19	repeated	repeat	VBN
cord-016293-pyb00pt5	324	20	.	.	.
cord-016293-pyb00pt5	325	1	Studies	study	NNS
cord-016293-pyb00pt5	325	2	are	be	VBP
cord-016293-pyb00pt5	325	3	underway	underway	JJ
cord-016293-pyb00pt5	325	4	to	to	TO
cord-016293-pyb00pt5	325	5	develop	develop	VB
cord-016293-pyb00pt5	325	6	gene	gene	NN
cord-016293-pyb00pt5	325	7	therapy	therapy	NN
cord-016293-pyb00pt5	325	8	techniques	technique	NNS
cord-016293-pyb00pt5	325	9	to	to	TO
cord-016293-pyb00pt5	325	10	replace	replace	VB
cord-016293-pyb00pt5	325	11	other	other	JJ
cord-016293-pyb00pt5	325	12	faulty	faulty	JJ
cord-016293-pyb00pt5	325	13	genes	gene	NNS
cord-016293-pyb00pt5	325	14	.	.	.
cord-016293-pyb00pt5	326	1	For	for	IN
cord-016293-pyb00pt5	326	2	example	example	NN
cord-016293-pyb00pt5	326	3	,	,	,
cord-016293-pyb00pt5	326	4	to	to	TO
cord-016293-pyb00pt5	326	5	replace	replace	VB
cord-016293-pyb00pt5	326	6	the	the	DT
cord-016293-pyb00pt5	326	7	genes	gene	NNS
cord-016293-pyb00pt5	326	8	responsible	responsible	JJ
cord-016293-pyb00pt5	326	9	for	for	IN
cord-016293-pyb00pt5	326	10	factor	factor	NN
cord-016293-pyb00pt5	326	11	VIII	VIII	NNP
cord-016293-pyb00pt5	326	12	and	and	CC
cord-016293-pyb00pt5	326	13	factor	factor	NN
cord-016293-pyb00pt5	326	14	IX	IX	NNP
cord-016293-pyb00pt5	326	15	production	production	NN
cord-016293-pyb00pt5	326	16	whose	whose	WP$
cord-016293-pyb00pt5	326	17	malfunctioning	malfunctioning	NN
cord-016293-pyb00pt5	326	18	causes	cause	VBZ
cord-016293-pyb00pt5	326	19	hemophilia	hemophilia	NN
cord-016293-pyb00pt5	326	20	A	a	NN
cord-016293-pyb00pt5	326	21	and	and	CC
cord-016293-pyb00pt5	326	22	B	b	NN
cord-016293-pyb00pt5	326	23	respectively	respectively	RB
cord-016293-pyb00pt5	326	24	;	;	:
cord-016293-pyb00pt5	326	25	and	and	CC
cord-016293-pyb00pt5	326	26	to	to	TO
cord-016293-pyb00pt5	326	27	alleviate	alleviate	VB
cord-016293-pyb00pt5	326	28	the	the	DT
cord-016293-pyb00pt5	326	29	effects	effect	NNS
cord-016293-pyb00pt5	326	30	of	of	IN
cord-016293-pyb00pt5	326	31	the	the	DT
cord-016293-pyb00pt5	326	32	faulty	faulty	JJ
cord-016293-pyb00pt5	326	33	gene	gene	NN
cord-016293-pyb00pt5	326	34	in	in	IN
cord-016293-pyb00pt5	326	35	dopamine	dopamine	NN
cord-016293-pyb00pt5	326	36	production	production	NN
cord-016293-pyb00pt5	326	37	that	that	WDT
cord-016293-pyb00pt5	326	38	results	result	VBZ
cord-016293-pyb00pt5	326	39	in	in	IN
cord-016293-pyb00pt5	326	40	Parkinson	Parkinson	NNP
cord-016293-pyb00pt5	326	41	's	's	POS
cord-016293-pyb00pt5	326	42	disease	disease	NN
cord-016293-pyb00pt5	326	43	.	.	.
cord-016293-pyb00pt5	327	1	Apart	apart	RB
cord-016293-pyb00pt5	327	2	from	from	IN
cord-016293-pyb00pt5	327	3	technical	technical	JJ
cord-016293-pyb00pt5	327	4	challenges	challenge	NNS
cord-016293-pyb00pt5	327	5	such	such	PDT
cord-016293-pyb00pt5	327	6	a	a	DT
cord-016293-pyb00pt5	327	7	radical	radical	JJ
cord-016293-pyb00pt5	327	8	therapy	therapy	NN
cord-016293-pyb00pt5	327	9	also	also	RB
cord-016293-pyb00pt5	327	10	engenders	engender	VBZ
cord-016293-pyb00pt5	327	11	ethical	ethical	JJ
cord-016293-pyb00pt5	327	12	debate	debate	NN
cord-016293-pyb00pt5	327	13	.	.	.
cord-016293-pyb00pt5	328	1	Many	many	JJ
cord-016293-pyb00pt5	328	2	persons	person	NNS
cord-016293-pyb00pt5	328	3	who	who	WP
cord-016293-pyb00pt5	328	4	voice	voice	VBP
cord-016293-pyb00pt5	328	5	concerns	concern	NNS
cord-016293-pyb00pt5	328	6	about	about	IN
cord-016293-pyb00pt5	328	7	somatic	somatic	JJ
cord-016293-pyb00pt5	328	8	-	-	HYPH
cord-016293-pyb00pt5	328	9	cell	cell	NN
cord-016293-pyb00pt5	328	10	gene	gene	NN
cord-016293-pyb00pt5	328	11	therapy	therapy	NN
cord-016293-pyb00pt5	328	12	use	use	VBP
cord-016293-pyb00pt5	328	13	a	a	DT
cord-016293-pyb00pt5	328	14	"	"	``
cord-016293-pyb00pt5	328	15	slippery	slippery	JJ
cord-016293-pyb00pt5	328	16	slope	slope	NN
cord-016293-pyb00pt5	328	17	"	"	''
cord-016293-pyb00pt5	328	18	argument	argument	NN
cord-016293-pyb00pt5	328	19	.	.	.
cord-016293-pyb00pt5	329	1	It	-PRON-	PRP
cord-016293-pyb00pt5	329	2	sounds	sound	VBZ
cord-016293-pyb00pt5	329	3	good	good	JJ
cord-016293-pyb00pt5	329	4	in	in	IN
cord-016293-pyb00pt5	329	5	theory	theory	NN
cord-016293-pyb00pt5	329	6	but	but	CC
cord-016293-pyb00pt5	329	7	where	where	WRB
cord-016293-pyb00pt5	329	8	does	do	VBZ
cord-016293-pyb00pt5	329	9	one	one	PRP
cord-016293-pyb00pt5	329	10	draw	draw	VB
cord-016293-pyb00pt5	329	11	the	the	DT
cord-016293-pyb00pt5	329	12	line	line	NN
cord-016293-pyb00pt5	329	13	.	.	.
cord-016293-pyb00pt5	330	1	There	there	EX
cord-016293-pyb00pt5	330	2	are	be	VBP
cord-016293-pyb00pt5	330	3	many	many	JJ
cord-016293-pyb00pt5	330	4	issues	issue	NNS
cord-016293-pyb00pt5	330	5	yet	yet	RB
cord-016293-pyb00pt5	330	6	to	to	TO
cord-016293-pyb00pt5	330	7	be	be	VB
cord-016293-pyb00pt5	330	8	resolved	resolve	VBN
cord-016293-pyb00pt5	330	9	in	in	IN
cord-016293-pyb00pt5	330	10	this	this	DT
cord-016293-pyb00pt5	330	11	field	field	NN
cord-016293-pyb00pt5	330	12	of	of	IN
cord-016293-pyb00pt5	330	13	thorny	thorny	JJ
cord-016293-pyb00pt5	330	14	ethics	ethic	NNS
cord-016293-pyb00pt5	330	15	"	"	``
cord-016293-pyb00pt5	330	16	good	good	JJ
cord-016293-pyb00pt5	330	17	"	"	''
cord-016293-pyb00pt5	330	18	and	and	CC
cord-016293-pyb00pt5	330	19	"	"	``
cord-016293-pyb00pt5	330	20	bad	bad	JJ
cord-016293-pyb00pt5	330	21	"	"	''
cord-016293-pyb00pt5	330	22	uses	use	NNS
cord-016293-pyb00pt5	330	23	of	of	IN
cord-016293-pyb00pt5	330	24	the	the	DT
cord-016293-pyb00pt5	330	25	gene	gene	NN
cord-016293-pyb00pt5	330	26	modification	modification	NN
cord-016293-pyb00pt5	330	27	,	,	,
cord-016293-pyb00pt5	330	28	difficulty	difficulty	NN
cord-016293-pyb00pt5	330	29	of	of	IN
cord-016293-pyb00pt5	330	30	following	follow	VBG
cord-016293-pyb00pt5	330	31	patients	patient	NNS
cord-016293-pyb00pt5	330	32	in	in	IN
cord-016293-pyb00pt5	330	33	long	long	JJ
cord-016293-pyb00pt5	330	34	-	-	HYPH
cord-016293-pyb00pt5	330	35	term	term	NN
cord-016293-pyb00pt5	330	36	clinical	clinical	JJ
cord-016293-pyb00pt5	330	37	research	research	NN
cord-016293-pyb00pt5	330	38	and	and	CC
cord-016293-pyb00pt5	330	39	such	such	JJ
cord-016293-pyb00pt5	330	40	.	.	.
cord-016293-pyb00pt5	331	1	Many	many	JJ
cord-016293-pyb00pt5	331	2	gene	gene	NN
cord-016293-pyb00pt5	331	3	therapy	therapy	NN
cord-016293-pyb00pt5	331	4	candidates	candidate	NNS
cord-016293-pyb00pt5	331	5	are	be	VBP
cord-016293-pyb00pt5	331	6	children	child	NNS
cord-016293-pyb00pt5	331	7	who	who	WP
cord-016293-pyb00pt5	331	8	are	be	VBP
cord-016293-pyb00pt5	331	9	too	too	RB
cord-016293-pyb00pt5	331	10	young	young	JJ
cord-016293-pyb00pt5	331	11	to	to	TO
cord-016293-pyb00pt5	331	12	understand	understand	VB
cord-016293-pyb00pt5	331	13	the	the	DT
cord-016293-pyb00pt5	331	14	ramifications	ramification	NNS
cord-016293-pyb00pt5	331	15	of	of	IN
cord-016293-pyb00pt5	331	16	this	this	DT
cord-016293-pyb00pt5	331	17	treatment	treatment	NN
cord-016293-pyb00pt5	331	18	:	:	:
cord-016293-pyb00pt5	331	19	Conflict	conflict	NN
cord-016293-pyb00pt5	331	20	of	of	IN
cord-016293-pyb00pt5	331	21	interest	interest	NN
cord-016293-pyb00pt5	331	22	-pits	-pits	:
cord-016293-pyb00pt5	331	23	individuals	individual	NNS
cord-016293-pyb00pt5	331	24	'	'	POS
cord-016293-pyb00pt5	331	25	reproductive	reproductive	JJ
cord-016293-pyb00pt5	331	26	liberties	liberty	NNS
cord-016293-pyb00pt5	331	27	and	and	CC
cord-016293-pyb00pt5	331	28	privacy	privacy	NN
cord-016293-pyb00pt5	331	29	interests	interest	NNS
cord-016293-pyb00pt5	331	30	against	against	IN
cord-016293-pyb00pt5	331	31	the	the	DT
cord-016293-pyb00pt5	331	32	interests	interest	NNS
cord-016293-pyb00pt5	331	33	of	of	IN
cord-016293-pyb00pt5	331	34	insurance	insurance	NN
cord-016293-pyb00pt5	331	35	companies	company	NNS
cord-016293-pyb00pt5	331	36	or	or	CC
cord-016293-pyb00pt5	331	37	society	society	NN
cord-016293-pyb00pt5	331	38	.	.	.
cord-016293-pyb00pt5	332	1	One	one	CD
cord-016293-pyb00pt5	332	2	issue	issue	NN
cord-016293-pyb00pt5	332	3	that	that	WDT
cord-016293-pyb00pt5	332	4	is	be	VBZ
cord-016293-pyb00pt5	332	5	unlikely	unlikely	JJ
cord-016293-pyb00pt5	332	6	to	to	TO
cord-016293-pyb00pt5	332	7	ever	ever	RB
cord-016293-pyb00pt5	332	8	gain	gain	VB
cord-016293-pyb00pt5	332	9	acceptance	acceptance	NN
cord-016293-pyb00pt5	332	10	is	be	VBZ
cord-016293-pyb00pt5	332	11	germline	germline	JJ
cord-016293-pyb00pt5	332	12	therapy	therapy	NN
cord-016293-pyb00pt5	332	13	,	,	,
cord-016293-pyb00pt5	332	14	the	the	DT
cord-016293-pyb00pt5	332	15	removal	removal	NN
cord-016293-pyb00pt5	332	16	of	of	IN
cord-016293-pyb00pt5	332	17	deleterious	deleterious	JJ
cord-016293-pyb00pt5	332	18	genes	gene	NNS
cord-016293-pyb00pt5	332	19	from	from	IN
cord-016293-pyb00pt5	332	20	the	the	DT
cord-016293-pyb00pt5	332	21	population	population	NN
cord-016293-pyb00pt5	332	22	.	.	.
cord-016293-pyb00pt5	333	1	Issues	issue	NNS
cord-016293-pyb00pt5	333	2	of	of	IN
cord-016293-pyb00pt5	333	3	justice	justice	NN
cord-016293-pyb00pt5	333	4	and	and	CC
cord-016293-pyb00pt5	333	5	resource	resource	NN
cord-016293-pyb00pt5	333	6	allocation	allocation	NN
cord-016293-pyb00pt5	333	7	also	also	RB
cord-016293-pyb00pt5	333	8	have	have	VBP
cord-016293-pyb00pt5	333	9	been	be	VBN
cord-016293-pyb00pt5	333	10	raised	raise	VBN
cord-016293-pyb00pt5	333	11	:	:	:
cord-016293-pyb00pt5	333	12	In	in	IN
cord-016293-pyb00pt5	333	13	a	a	DT
cord-016293-pyb00pt5	333	14	time	time	NN
cord-016293-pyb00pt5	333	15	of	of	IN
cord-016293-pyb00pt5	333	16	strain	strain	NN
cord-016293-pyb00pt5	333	17	on	on	IN
cord-016293-pyb00pt5	333	18	our	-PRON-	PRP$
cord-016293-pyb00pt5	333	19	health	health	NN
cord-016293-pyb00pt5	333	20	care	care	NN
cord-016293-pyb00pt5	333	21	system	system	NN
cord-016293-pyb00pt5	333	22	,	,	,
cord-016293-pyb00pt5	333	23	can	can	MD
cord-016293-pyb00pt5	333	24	we	-PRON-	PRP
cord-016293-pyb00pt5	333	25	afford	afford	VB
cord-016293-pyb00pt5	333	26	such	such	JJ
cord-016293-pyb00pt5	333	27	expensive	expensive	JJ
cord-016293-pyb00pt5	333	28	therapy	therapy	NN
cord-016293-pyb00pt5	333	29	?	?	.
cord-016293-pyb00pt5	334	1	Who	who	WP
cord-016293-pyb00pt5	334	2	should	should	MD
cord-016293-pyb00pt5	334	3	receive	receive	VB
cord-016293-pyb00pt5	334	4	gene	gene	NN
cord-016293-pyb00pt5	334	5	therapy	therapy	NN
cord-016293-pyb00pt5	334	6	?	?	.
cord-016293-pyb00pt5	335	1	If	if	IN
cord-016293-pyb00pt5	335	2	it	-PRON-	PRP
cord-016293-pyb00pt5	335	3	is	be	VBZ
cord-016293-pyb00pt5	335	4	made	make	VBN
cord-016293-pyb00pt5	335	5	available	available	JJ
cord-016293-pyb00pt5	335	6	only	only	RB
cord-016293-pyb00pt5	335	7	to	to	IN
cord-016293-pyb00pt5	335	8	those	those	DT
cord-016293-pyb00pt5	335	9	who	who	WP
cord-016293-pyb00pt5	335	10	can	can	MD
cord-016293-pyb00pt5	335	11	afford	afford	VB
cord-016293-pyb00pt5	335	12	it	-PRON-	PRP
cord-016293-pyb00pt5	335	13	,	,	,
cord-016293-pyb00pt5	335	14	then	then	RB
cord-016293-pyb00pt5	335	15	a	a	DT
cord-016293-pyb00pt5	335	16	number	number	NN
cord-016293-pyb00pt5	335	17	of	of	IN
cord-016293-pyb00pt5	335	18	civil	civil	JJ
cord-016293-pyb00pt5	335	19	rights	right	NNS
cord-016293-pyb00pt5	335	20	groups	group	NNS
cord-016293-pyb00pt5	335	21	claim	claim	VBP
cord-016293-pyb00pt5	335	22	that	that	IN
cord-016293-pyb00pt5	335	23	the	the	DT
cord-016293-pyb00pt5	335	24	distribution	distribution	NN
cord-016293-pyb00pt5	335	25	of	of	IN
cord-016293-pyb00pt5	335	26	desirable	desirable	JJ
cord-016293-pyb00pt5	335	27	biological	biological	JJ
cord-016293-pyb00pt5	335	28	traits	trait	NNS
cord-016293-pyb00pt5	335	29	among	among	IN
cord-016293-pyb00pt5	335	30	different	different	JJ
cord-016293-pyb00pt5	335	31	socioeconomic	socioeconomic	JJ
cord-016293-pyb00pt5	335	32	and	and	CC
cord-016293-pyb00pt5	335	33	ethnic	ethnic	JJ
cord-016293-pyb00pt5	335	34	groups	group	NNS
cord-016293-pyb00pt5	335	35	would	would	MD
cord-016293-pyb00pt5	335	36	become	become	VB
cord-016293-pyb00pt5	335	37	badly	badly	RB
cord-016293-pyb00pt5	335	38	skewed	skewed	JJ
cord-016293-pyb00pt5	335	39	adding	add	VBG
cord-016293-pyb00pt5	335	40	a	a	DT
cord-016293-pyb00pt5	335	41	new	new	JJ
cord-016293-pyb00pt5	335	42	and	and	CC
cord-016293-pyb00pt5	335	43	disturbing	disturbing	JJ
cord-016293-pyb00pt5	335	44	layer	layer	NN
cord-016293-pyb00pt5	335	45	of	of	IN
cord-016293-pyb00pt5	335	46	discriminatory	discriminatory	JJ
cord-016293-pyb00pt5	335	47	behavior	behavior	NN
cord-016293-pyb00pt5	335	48	.	.	.
cord-016293-pyb00pt5	336	1	Indeed	indeed	RB
cord-016293-pyb00pt5	336	2	a	a	DT
cord-016293-pyb00pt5	336	3	major	major	JJ
cord-016293-pyb00pt5	336	4	setback	setback	NN
cord-016293-pyb00pt5	336	5	occurred	occur	VBD
cord-016293-pyb00pt5	336	6	before	before	IN
cord-016293-pyb00pt5	336	7	the	the	DT
cord-016293-pyb00pt5	336	8	end	end	NN
cord-016293-pyb00pt5	336	9	of	of	IN
cord-016293-pyb00pt5	336	10	the	the	DT
cord-016293-pyb00pt5	336	11	decade	decade	NN
cord-016293-pyb00pt5	336	12	in	in	IN
cord-016293-pyb00pt5	336	13	1999	1999	CD
cord-016293-pyb00pt5	336	14	.	.	.
cord-016293-pyb00pt5	337	1	Jesse	Jesse	NNP
cord-016293-pyb00pt5	337	2	Gelsinger	Gelsinger	NNP
cord-016293-pyb00pt5	337	3	was	be	VBD
cord-016293-pyb00pt5	337	4	the	the	DT
cord-016293-pyb00pt5	337	5	first	first	JJ
cord-016293-pyb00pt5	337	6	person	person	NN
cord-016293-pyb00pt5	337	7	to	to	TO
cord-016293-pyb00pt5	337	8	die	die	VB
cord-016293-pyb00pt5	337	9	from	from	IN
cord-016293-pyb00pt5	337	10	gene	gene	NN
cord-016293-pyb00pt5	337	11	therapy	therapy	NN
cord-016293-pyb00pt5	337	12	,	,	,
cord-016293-pyb00pt5	337	13	on	on	IN
cord-016293-pyb00pt5	337	14	September	September	NNP
cord-016293-pyb00pt5	337	15	17	17	CD
cord-016293-pyb00pt5	337	16	,	,	,
cord-016293-pyb00pt5	337	17	1999	1999	CD
cord-016293-pyb00pt5	337	18	,	,	,
cord-016293-pyb00pt5	337	19	and	and	CC
cord-016293-pyb00pt5	337	20	his	-PRON-	PRP$
cord-016293-pyb00pt5	337	21	death	death	NN
cord-016293-pyb00pt5	337	22	created	create	VBD
cord-016293-pyb00pt5	337	23	another	another	DT
cord-016293-pyb00pt5	337	24	unprecedented	unprecedented	JJ
cord-016293-pyb00pt5	337	25	situation	situation	NN
cord-016293-pyb00pt5	337	26	when	when	WRB
cord-016293-pyb00pt5	337	27	his	-PRON-	PRP$
cord-016293-pyb00pt5	337	28	family	family	NN
cord-016293-pyb00pt5	337	29	sued	sue	VBD
cord-016293-pyb00pt5	337	30	not	not	RB
cord-016293-pyb00pt5	337	31	only	only	RB
cord-016293-pyb00pt5	337	32	the	the	DT
cord-016293-pyb00pt5	337	33	research	research	NN
cord-016293-pyb00pt5	337	34	team	team	NN
cord-016293-pyb00pt5	337	35	involved	involve	VBN
cord-016293-pyb00pt5	337	36	in	in	IN
cord-016293-pyb00pt5	337	37	the	the	DT
cord-016293-pyb00pt5	337	38	experiment	experiment	NN
cord-016293-pyb00pt5	337	39	(	(	-LRB-
cord-016293-pyb00pt5	337	40	U	U	NNP
cord-016293-pyb00pt5	337	41	Penn	Penn	NNP
cord-016293-pyb00pt5	337	42	)	)	-RRB-
cord-016293-pyb00pt5	337	43	,	,	,
cord-016293-pyb00pt5	337	44	the	the	DT
cord-016293-pyb00pt5	337	45	company	company	NN
cord-016293-pyb00pt5	337	46	Genovo	Genovo	NNP
cord-016293-pyb00pt5	337	47	Inc.	Inc.	NNP
cord-016293-pyb00pt5	337	48	,	,	,
cord-016293-pyb00pt5	337	49	but	but	CC
cord-016293-pyb00pt5	337	50	also	also	RB
cord-016293-pyb00pt5	337	51	the	the	DT
cord-016293-pyb00pt5	337	52	ethicist	ethicist	NN
cord-016293-pyb00pt5	337	53	who	who	WP
cord-016293-pyb00pt5	337	54	offered	offer	VBD
cord-016293-pyb00pt5	337	55	moral	moral	JJ
cord-016293-pyb00pt5	337	56	advice	advice	NN
cord-016293-pyb00pt5	337	57	on	on	IN
cord-016293-pyb00pt5	337	58	the	the	DT
cord-016293-pyb00pt5	337	59	controversial	controversial	JJ
cord-016293-pyb00pt5	337	60	project	project	NN
cord-016293-pyb00pt5	337	61	.	.	.
cord-016293-pyb00pt5	338	1	This	this	DT
cord-016293-pyb00pt5	338	2	inclusion	inclusion	NN
cord-016293-pyb00pt5	338	3	of	of	IN
cord-016293-pyb00pt5	338	4	the	the	DT
cord-016293-pyb00pt5	338	5	ethicist	ethicist	NN
cord-016293-pyb00pt5	338	6	as	as	IN
cord-016293-pyb00pt5	338	7	a	a	DT
cord-016293-pyb00pt5	338	8	defendant	defendant	NN
cord-016293-pyb00pt5	338	9	alongside	alongside	IN
cord-016293-pyb00pt5	338	10	the	the	DT
cord-016293-pyb00pt5	338	11	scientists	scientist	NNS
cord-016293-pyb00pt5	338	12	and	and	CC
cord-016293-pyb00pt5	338	13	school	school	NN
cord-016293-pyb00pt5	338	14	was	be	VBD
cord-016293-pyb00pt5	338	15	a	a	DT
cord-016293-pyb00pt5	338	16	surprising	surprising	JJ
cord-016293-pyb00pt5	338	17	legal	legal	JJ
cord-016293-pyb00pt5	338	18	move	move	NN
cord-016293-pyb00pt5	338	19	that	that	WDT
cord-016293-pyb00pt5	338	20	puts	put	VBZ
cord-016293-pyb00pt5	338	21	this	this	DT
cord-016293-pyb00pt5	338	22	specialty	specialty	NN
cord-016293-pyb00pt5	338	23	on	on	IN
cord-016293-pyb00pt5	338	24	notice	notice	NN
cord-016293-pyb00pt5	338	25	,	,	,
cord-016293-pyb00pt5	338	26	as	as	IN
cord-016293-pyb00pt5	338	27	will	will	MD
cord-016293-pyb00pt5	338	28	no	no	RB
cord-016293-pyb00pt5	338	29	doubt	doubt	RB
cord-016293-pyb00pt5	338	30	be	be	VB
cord-016293-pyb00pt5	338	31	the	the	DT
cord-016293-pyb00pt5	338	32	case	case	NN
cord-016293-pyb00pt5	338	33	with	with	IN
cord-016293-pyb00pt5	338	34	other	other	JJ
cord-016293-pyb00pt5	338	35	evolving	evolve	VBG
cord-016293-pyb00pt5	338	36	technologies	technology	NNS
cord-016293-pyb00pt5	338	37	such	such	JJ
cord-016293-pyb00pt5	338	38	as	as	IN
cord-016293-pyb00pt5	338	39	stem	stem	NN
cord-016293-pyb00pt5	338	40	cells	cell	NNS
cord-016293-pyb00pt5	338	41	and	and	CC
cord-016293-pyb00pt5	338	42	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	338	43	cloning	cloning	NN
cord-016293-pyb00pt5	338	44	,	,	,
cord-016293-pyb00pt5	338	45	that	that	IN
cord-016293-pyb00pt5	338	46	its	-PRON-	PRP$
cord-016293-pyb00pt5	338	47	members	member	NNS
cord-016293-pyb00pt5	338	48	could	could	MD
cord-016293-pyb00pt5	338	49	be	be	VB
cord-016293-pyb00pt5	338	50	vulnerable	vulnerable	JJ
cord-016293-pyb00pt5	338	51	to	to	IN
cord-016293-pyb00pt5	338	52	litigation	litigation	NN
cord-016293-pyb00pt5	338	53	over	over	IN
cord-016293-pyb00pt5	338	54	the	the	DT
cord-016293-pyb00pt5	338	55	philosophical	philosophical	JJ
cord-016293-pyb00pt5	338	56	guidance	guidance	NN
cord-016293-pyb00pt5	338	57	they	-PRON-	PRP
cord-016293-pyb00pt5	338	58	provide	provide	VBP
cord-016293-pyb00pt5	338	59	to	to	IN
cord-016293-pyb00pt5	338	60	researchers	researcher	NNS
cord-016293-pyb00pt5	338	61	.	.	.
cord-016293-pyb00pt5	339	1	The	the	DT
cord-016293-pyb00pt5	339	2	Penn	Penn	NNP
cord-016293-pyb00pt5	339	3	group	group	NN
cord-016293-pyb00pt5	339	4	principal	principal	JJ
cord-016293-pyb00pt5	339	5	investigator	investigator	NN
cord-016293-pyb00pt5	339	6	James	James	NNP
cord-016293-pyb00pt5	339	7	Wilson	Wilson	NNP
cord-016293-pyb00pt5	339	8	approached	approach	VBD
cord-016293-pyb00pt5	339	9	ethicist	ethicist	NN
cord-016293-pyb00pt5	339	10	Arthur	Arthur	NNP
cord-016293-pyb00pt5	339	11	Caplan	Caplan	NNP
cord-016293-pyb00pt5	339	12	about	about	IN
cord-016293-pyb00pt5	339	13	their	-PRON-	PRP$
cord-016293-pyb00pt5	339	14	plans	plan	NNS
cord-016293-pyb00pt5	339	15	to	to	TO
cord-016293-pyb00pt5	339	16	test	test	VB
cord-016293-pyb00pt5	339	17	the	the	DT
cord-016293-pyb00pt5	339	18	safety	safety	NN
cord-016293-pyb00pt5	339	19	of	of	IN
cord-016293-pyb00pt5	339	20	a	a	DT
cord-016293-pyb00pt5	339	21	genetically	genetically	RB
cord-016293-pyb00pt5	339	22	engineered	engineer	VBN
cord-016293-pyb00pt5	339	23	virus	virus	NN
cord-016293-pyb00pt5	339	24	on	on	IN
cord-016293-pyb00pt5	339	25	babies	baby	NNS
cord-016293-pyb00pt5	339	26	with	with	IN
cord-016293-pyb00pt5	339	27	a	a	DT
cord-016293-pyb00pt5	339	28	deadly	deadly	JJ
cord-016293-pyb00pt5	339	29	form	form	NN
cord-016293-pyb00pt5	339	30	of	of	IN
cord-016293-pyb00pt5	339	31	the	the	DT
cord-016293-pyb00pt5	339	32	liver	liver	NN
cord-016293-pyb00pt5	339	33	disorder	disorder	NN
cord-016293-pyb00pt5	339	34	,	,	,
cord-016293-pyb00pt5	339	35	ornithine	ornithine	NN
cord-016293-pyb00pt5	339	36	transcarbamylase	transcarbamylase	NN
cord-016293-pyb00pt5	339	37	deficiency	deficiency	NN
cord-016293-pyb00pt5	339	38	.	.	.
cord-016293-pyb00pt5	340	1	The	the	DT
cord-016293-pyb00pt5	340	2	disorder	disorder	NN
cord-016293-pyb00pt5	340	3	allows	allow	VBZ
cord-016293-pyb00pt5	340	4	poisonous	poisonous	JJ
cord-016293-pyb00pt5	340	5	levels	level	NNS
cord-016293-pyb00pt5	340	6	of	of	IN
cord-016293-pyb00pt5	340	7	ammonia	ammonia	NN
cord-016293-pyb00pt5	340	8	to	to	TO
cord-016293-pyb00pt5	340	9	build	build	VB
cord-016293-pyb00pt5	340	10	up	up	RP
cord-016293-pyb00pt5	340	11	in	in	IN
cord-016293-pyb00pt5	340	12	the	the	DT
cord-016293-pyb00pt5	340	13	blood	blood	NN
cord-016293-pyb00pt5	340	14	system	system	NN
cord-016293-pyb00pt5	340	15	.	.	.
cord-016293-pyb00pt5	341	1	Caplan	Caplan	NNP
cord-016293-pyb00pt5	341	2	steered	steer	VBD
cord-016293-pyb00pt5	341	3	the	the	DT
cord-016293-pyb00pt5	341	4	researchers	researcher	NNS
cord-016293-pyb00pt5	341	5	away	away	RB
cord-016293-pyb00pt5	341	6	from	from	IN
cord-016293-pyb00pt5	341	7	sick	sick	JJ
cord-016293-pyb00pt5	341	8	infants	infant	NNS
cord-016293-pyb00pt5	341	9	,	,	,
cord-016293-pyb00pt5	341	10	arguing	argue	VBG
cord-016293-pyb00pt5	341	11	that	that	IN
cord-016293-pyb00pt5	341	12	desperate	desperate	JJ
cord-016293-pyb00pt5	341	13	parents	parent	NNS
cord-016293-pyb00pt5	341	14	could	could	MD
cord-016293-pyb00pt5	341	15	not	not	RB
cord-016293-pyb00pt5	341	16	provide	provide	VB
cord-016293-pyb00pt5	341	17	true	true	JJ
cord-016293-pyb00pt5	341	18	informed	informed	JJ
cord-016293-pyb00pt5	341	19	consent	consent	NN
cord-016293-pyb00pt5	341	20	.	.	.
cord-016293-pyb00pt5	342	1	He	-PRON-	PRP
cord-016293-pyb00pt5	342	2	said	say	VBD
cord-016293-pyb00pt5	342	3	it	-PRON-	PRP
cord-016293-pyb00pt5	342	4	would	would	MD
cord-016293-pyb00pt5	342	5	be	be	VB
cord-016293-pyb00pt5	342	6	better	well	JJR
cord-016293-pyb00pt5	342	7	to	to	TO
cord-016293-pyb00pt5	342	8	experiment	experiment	VB
cord-016293-pyb00pt5	342	9	on	on	IN
cord-016293-pyb00pt5	342	10	adults	adult	NNS
cord-016293-pyb00pt5	342	11	with	with	IN
cord-016293-pyb00pt5	342	12	a	a	DT
cord-016293-pyb00pt5	342	13	less	less	RBR
cord-016293-pyb00pt5	342	14	lethal	lethal	JJ
cord-016293-pyb00pt5	342	15	form	form	NN
cord-016293-pyb00pt5	342	16	of	of	IN
cord-016293-pyb00pt5	342	17	the	the	DT
cord-016293-pyb00pt5	342	18	disease	disease	NN
cord-016293-pyb00pt5	342	19	who	who	WP
cord-016293-pyb00pt5	342	20	were	be	VBD
cord-016293-pyb00pt5	342	21	relatively	relatively	RB
cord-016293-pyb00pt5	342	22	healthy	healthy	JJ
cord-016293-pyb00pt5	342	23	.	.	.
cord-016293-pyb00pt5	343	1	Gelsinger	Gelsinger	NNP
cord-016293-pyb00pt5	343	2	fell	fall	VBD
cord-016293-pyb00pt5	343	3	into	into	IN
cord-016293-pyb00pt5	343	4	that	that	DT
cord-016293-pyb00pt5	343	5	category	category	NN
cord-016293-pyb00pt5	343	6	.	.	.
cord-016293-pyb00pt5	344	1	Although	although	IN
cord-016293-pyb00pt5	344	2	he	-PRON-	PRP
cord-016293-pyb00pt5	344	3	had	have	VBD
cord-016293-pyb00pt5	344	4	suffered	suffer	VBN
cord-016293-pyb00pt5	344	5	serious	serious	JJ
cord-016293-pyb00pt5	344	6	bouts	bout	NNS
cord-016293-pyb00pt5	344	7	of	of	IN
cord-016293-pyb00pt5	344	8	ammonia	ammonia	NN
cord-016293-pyb00pt5	344	9	buildup	buildup	NN
cord-016293-pyb00pt5	344	10	,	,	,
cord-016293-pyb00pt5	344	11	he	-PRON-	PRP
cord-016293-pyb00pt5	344	12	was	be	VBD
cord-016293-pyb00pt5	344	13	doing	do	VBG
cord-016293-pyb00pt5	344	14	well	well	RB
cord-016293-pyb00pt5	344	15	on	on	IN
cord-016293-pyb00pt5	344	16	a	a	DT
cord-016293-pyb00pt5	344	17	special	special	JJ
cord-016293-pyb00pt5	344	18	drug	drug	NN
cord-016293-pyb00pt5	344	19	and	and	CC
cord-016293-pyb00pt5	344	20	diet	diet	NN
cord-016293-pyb00pt5	344	21	regimen	regimen	NN
cord-016293-pyb00pt5	344	22	.	.	.
cord-016293-pyb00pt5	345	1	The	the	DT
cord-016293-pyb00pt5	345	2	decision	decision	NN
cord-016293-pyb00pt5	345	3	to	to	TO
cord-016293-pyb00pt5	345	4	use	use	VB
cord-016293-pyb00pt5	345	5	relatively	relatively	RB
cord-016293-pyb00pt5	345	6	healthy	healthy	JJ
cord-016293-pyb00pt5	345	7	adults	adult	NNS
cord-016293-pyb00pt5	345	8	was	be	VBD
cord-016293-pyb00pt5	345	9	controversial	controversial	JJ
cord-016293-pyb00pt5	345	10	because	because	IN
cord-016293-pyb00pt5	345	11	risky	risky	JJ
cord-016293-pyb00pt5	345	12	,	,	,
cord-016293-pyb00pt5	345	13	unproven	unproven	JJ
cord-016293-pyb00pt5	345	14	experimental	experimental	JJ
cord-016293-pyb00pt5	345	15	protocols	protocol	NNS
cord-016293-pyb00pt5	345	16	generally	generally	RB
cord-016293-pyb00pt5	345	17	use	use	VBP
cord-016293-pyb00pt5	345	18	very	very	RB
cord-016293-pyb00pt5	345	19	ill	ill	JJ
cord-016293-pyb00pt5	345	20	people	people	NNS
cord-016293-pyb00pt5	345	21	who	who	WP
cord-016293-pyb00pt5	345	22	have	have	VBP
cord-016293-pyb00pt5	345	23	exhausted	exhaust	VBN
cord-016293-pyb00pt5	345	24	more	more	RBR
cord-016293-pyb00pt5	345	25	traditional	traditional	JJ
cord-016293-pyb00pt5	345	26	treatments	treatment	NNS
cord-016293-pyb00pt5	345	27	,	,	,
cord-016293-pyb00pt5	345	28	so	so	RB
cord-016293-pyb00pt5	345	29	have	have	VBP
cord-016293-pyb00pt5	345	30	little	little	JJ
cord-016293-pyb00pt5	345	31	to	to	TO
cord-016293-pyb00pt5	345	32	lose	lose	VB
cord-016293-pyb00pt5	345	33	.	.	.
cord-016293-pyb00pt5	346	1	In	in	IN
cord-016293-pyb00pt5	346	2	this	this	DT
cord-016293-pyb00pt5	346	3	case	case	NN
cord-016293-pyb00pt5	346	4	,	,	,
cord-016293-pyb00pt5	346	5	the	the	DT
cord-016293-pyb00pt5	346	6	virus	virus	NN
cord-016293-pyb00pt5	346	7	used	use	VBD
cord-016293-pyb00pt5	346	8	to	to	TO
cord-016293-pyb00pt5	346	9	deliver	deliver	VB
cord-016293-pyb00pt5	346	10	the	the	DT
cord-016293-pyb00pt5	346	11	genes	gene	NNS
cord-016293-pyb00pt5	346	12	was	be	VBD
cord-016293-pyb00pt5	346	13	known	know	VBN
cord-016293-pyb00pt5	346	14	to	to	TO
cord-016293-pyb00pt5	346	15	cause	cause	VB
cord-016293-pyb00pt5	346	16	liver	liver	NN
cord-016293-pyb00pt5	346	17	damage	damage	NN
cord-016293-pyb00pt5	346	18	,	,	,
cord-016293-pyb00pt5	346	19	so	so	IN
cord-016293-pyb00pt5	346	20	some	some	DT
cord-016293-pyb00pt5	346	21	scientists	scientist	NNS
cord-016293-pyb00pt5	346	22	were	be	VBD
cord-016293-pyb00pt5	346	23	concerned	concern	VBN
cord-016293-pyb00pt5	346	24	it	-PRON-	PRP
cord-016293-pyb00pt5	346	25	might	may	MD
cord-016293-pyb00pt5	346	26	trigger	trigger	VB
cord-016293-pyb00pt5	346	27	an	an	DT
cord-016293-pyb00pt5	346	28	ammonia	ammonia	NN
cord-016293-pyb00pt5	346	29	crisis	crisis	NN
cord-016293-pyb00pt5	346	30	in	in	IN
cord-016293-pyb00pt5	346	31	the	the	DT
cord-016293-pyb00pt5	346	32	adults	adult	NNS
cord-016293-pyb00pt5	346	33	.	.	.
cord-016293-pyb00pt5	347	1	Wilson	Wilson	NNP
cord-016293-pyb00pt5	347	2	underestimated	underestimate	VBD
cord-016293-pyb00pt5	347	3	the	the	DT
cord-016293-pyb00pt5	347	4	risk	risk	NN
cord-016293-pyb00pt5	347	5	of	of	IN
cord-016293-pyb00pt5	347	6	the	the	DT
cord-016293-pyb00pt5	347	7	experiment	experiment	NN
cord-016293-pyb00pt5	347	8	,	,	,
cord-016293-pyb00pt5	347	9	omitted	omit	VBD
cord-016293-pyb00pt5	347	10	the	the	DT
cord-016293-pyb00pt5	347	11	disclosure	disclosure	NN
cord-016293-pyb00pt5	347	12	about	about	IN
cord-016293-pyb00pt5	347	13	possible	possible	JJ
cord-016293-pyb00pt5	347	14	liver	liver	NN
cord-016293-pyb00pt5	347	15	damage	damage	NN
cord-016293-pyb00pt5	347	16	in	in	IN
cord-016293-pyb00pt5	347	17	earlier	early	JJR
cord-016293-pyb00pt5	347	18	volunteers	volunteer	NNS
cord-016293-pyb00pt5	347	19	in	in	IN
cord-016293-pyb00pt5	347	20	the	the	DT
cord-016293-pyb00pt5	347	21	experiment	experiment	NN
cord-016293-pyb00pt5	347	22	and	and	CC
cord-016293-pyb00pt5	347	23	failed	fail	VBD
cord-016293-pyb00pt5	347	24	to	to	TO
cord-016293-pyb00pt5	347	25	mention	mention	VB
cord-016293-pyb00pt5	347	26	the	the	DT
cord-016293-pyb00pt5	347	27	deaths	death	NNS
cord-016293-pyb00pt5	347	28	of	of	IN
cord-016293-pyb00pt5	347	29	monkeys	monkey	NNS
cord-016293-pyb00pt5	347	30	given	give	VBN
cord-016293-pyb00pt5	347	31	a	a	DT
cord-016293-pyb00pt5	347	32	similar	similar	JJ
cord-016293-pyb00pt5	347	33	treatment	treatment	NN
cord-016293-pyb00pt5	347	34	during	during	IN
cord-016293-pyb00pt5	347	35	pre	pre	JJ
cord-016293-pyb00pt5	347	36	-	-	JJ
cord-016293-pyb00pt5	347	37	clinical	clinical	JJ
cord-016293-pyb00pt5	347	38	studies	study	NNS
cord-016293-pyb00pt5	347	39	.	.	.
cord-016293-pyb00pt5	348	1	A	a	DT
cord-016293-pyb00pt5	348	2	Food	Food	NNP
cord-016293-pyb00pt5	348	3	and	and	CC
cord-016293-pyb00pt5	348	4	Drug	Drug	NNP
cord-016293-pyb00pt5	348	5	Administration	Administration	NNP
cord-016293-pyb00pt5	348	6	investigation	investigation	NN
cord-016293-pyb00pt5	348	7	after	after	IN
cord-016293-pyb00pt5	348	8	Gelsinger	Gelsinger	NNP
cord-016293-pyb00pt5	348	9	's	's	POS
cord-016293-pyb00pt5	348	10	death	death	NN
cord-016293-pyb00pt5	348	11	found	find	VBD
cord-016293-pyb00pt5	348	12	numerous	numerous	JJ
cord-016293-pyb00pt5	348	13	regulatory	regulatory	JJ
cord-016293-pyb00pt5	348	14	violations	violation	NNS
cord-016293-pyb00pt5	348	15	by	by	IN
cord-016293-pyb00pt5	348	16	Wilson	Wilson	NNP
cord-016293-pyb00pt5	348	17	's	's	POS
cord-016293-pyb00pt5	348	18	team	team	NN
cord-016293-pyb00pt5	348	19	,	,	,
cord-016293-pyb00pt5	348	20	including	include	VBG
cord-016293-pyb00pt5	348	21	the	the	DT
cord-016293-pyb00pt5	348	22	failure	failure	NN
cord-016293-pyb00pt5	348	23	to	to	TO
cord-016293-pyb00pt5	348	24	stop	stop	VB
cord-016293-pyb00pt5	348	25	the	the	DT
cord-016293-pyb00pt5	348	26	experiment	experiment	NN
cord-016293-pyb00pt5	348	27	and	and	CC
cord-016293-pyb00pt5	348	28	inform	inform	VB
cord-016293-pyb00pt5	348	29	the	the	DT
cord-016293-pyb00pt5	348	30	FDA	FDA	NNP
cord-016293-pyb00pt5	348	31	after	after	IN
cord-016293-pyb00pt5	348	32	four	four	CD
cord-016293-pyb00pt5	348	33	successive	successive	JJ
cord-016293-pyb00pt5	348	34	volunteers	volunteer	NNS
cord-016293-pyb00pt5	348	35	suffered	suffer	VBD
cord-016293-pyb00pt5	348	36	serious	serious	JJ
cord-016293-pyb00pt5	348	37	liver	liver	NN
cord-016293-pyb00pt5	348	38	damage	damage	NN
cord-016293-pyb00pt5	348	39	prior	prior	RB
cord-016293-pyb00pt5	348	40	to	to	IN
cord-016293-pyb00pt5	348	41	the	the	DT
cord-016293-pyb00pt5	348	42	teen	teen	NN
cord-016293-pyb00pt5	348	43	's	's	POS
cord-016293-pyb00pt5	348	44	treatment	treatment	NN
cord-016293-pyb00pt5	348	45	.	.	.
cord-016293-pyb00pt5	349	1	In	in	IN
cord-016293-pyb00pt5	349	2	addition	addition	NN
cord-016293-pyb00pt5	349	3	,	,	,
cord-016293-pyb00pt5	349	4	the	the	DT
cord-016293-pyb00pt5	349	5	FDA	FDA	NNP
cord-016293-pyb00pt5	349	6	said	say	VBD
cord-016293-pyb00pt5	349	7	Gelsinger	Gelsinger	NNP
cord-016293-pyb00pt5	349	8	did	do	VBD
cord-016293-pyb00pt5	349	9	not	not	RB
cord-016293-pyb00pt5	349	10	qualify	qualify	VB
cord-016293-pyb00pt5	349	11	for	for	IN
cord-016293-pyb00pt5	349	12	the	the	DT
cord-016293-pyb00pt5	349	13	experiment	experiment	NN
cord-016293-pyb00pt5	349	14	,	,	,
cord-016293-pyb00pt5	349	15	because	because	IN
cord-016293-pyb00pt5	349	16	his	-PRON-	PRP$
cord-016293-pyb00pt5	349	17	blood	blood	NN
cord-016293-pyb00pt5	349	18	ammonia	ammonia	NN
cord-016293-pyb00pt5	349	19	levels	level	NNS
cord-016293-pyb00pt5	349	20	were	be	VBD
cord-016293-pyb00pt5	349	21	too	too	RB
cord-016293-pyb00pt5	349	22	high	high	JJ
cord-016293-pyb00pt5	349	23	just	just	RB
cord-016293-pyb00pt5	349	24	before	before	IN
cord-016293-pyb00pt5	349	25	he	-PRON-	PRP
cord-016293-pyb00pt5	349	26	underwent	undergo	VBD
cord-016293-pyb00pt5	349	27	the	the	DT
cord-016293-pyb00pt5	349	28	infusion	infusion	NN
cord-016293-pyb00pt5	349	29	of	of	IN
cord-016293-pyb00pt5	349	30	genetic	genetic	JJ
cord-016293-pyb00pt5	349	31	material	material	NN
cord-016293-pyb00pt5	349	32	.	.	.
cord-016293-pyb00pt5	350	1	The	the	DT
cord-016293-pyb00pt5	350	2	FDA	FDA	NNP
cord-016293-pyb00pt5	350	3	suspended	suspend	VBD
cord-016293-pyb00pt5	350	4	all	all	DT
cord-016293-pyb00pt5	350	5	human	human	JJ
cord-016293-pyb00pt5	350	6	gene	gene	NN
cord-016293-pyb00pt5	350	7	experiments	experiment	NNS
cord-016293-pyb00pt5	350	8	by	by	IN
cord-016293-pyb00pt5	350	9	Wilson	Wilson	NNP
cord-016293-pyb00pt5	350	10	and	and	CC
cord-016293-pyb00pt5	350	11	the	the	DT
cord-016293-pyb00pt5	350	12	University	University	NNP
cord-016293-pyb00pt5	350	13	of	of	IN
cord-016293-pyb00pt5	350	14	Penn	Penn	NNP
cord-016293-pyb00pt5	350	15	subsequently	subsequently	RB
cord-016293-pyb00pt5	350	16	restricting	restrict	VBG
cord-016293-pyb00pt5	350	17	him	-PRON-	PRP
cord-016293-pyb00pt5	350	18	solely	solely	RB
cord-016293-pyb00pt5	350	19	to	to	IN
cord-016293-pyb00pt5	350	20	animal	animal	NN
cord-016293-pyb00pt5	350	21	studies	study	NNS
cord-016293-pyb00pt5	350	22	.	.	.
cord-016293-pyb00pt5	351	1	A	a	DT
cord-016293-pyb00pt5	351	2	follow	follow	VB
cord-016293-pyb00pt5	351	3	-	-	HYPH
cord-016293-pyb00pt5	351	4	up	up	RP
cord-016293-pyb00pt5	351	5	FDA	FDA	NNP
cord-016293-pyb00pt5	351	6	investigation	investigation	NN
cord-016293-pyb00pt5	351	7	subsequently	subsequently	RB
cord-016293-pyb00pt5	351	8	alleged	allege	VBD
cord-016293-pyb00pt5	351	9	he	-PRON-	PRP
cord-016293-pyb00pt5	351	10	improperly	improperly	RB
cord-016293-pyb00pt5	351	11	tested	test	VBD
cord-016293-pyb00pt5	351	12	the	the	DT
cord-016293-pyb00pt5	351	13	experimental	experimental	JJ
cord-016293-pyb00pt5	351	14	treatment	treatment	NN
cord-016293-pyb00pt5	351	15	on	on	IN
cord-016293-pyb00pt5	351	16	animals	animal	NNS
cord-016293-pyb00pt5	351	17	.	.	.
cord-016293-pyb00pt5	352	1	Financial	financial	JJ
cord-016293-pyb00pt5	352	2	conflicts	conflict	NNS
cord-016293-pyb00pt5	352	3	of	of	IN
cord-016293-pyb00pt5	352	4	interest	interest	NN
cord-016293-pyb00pt5	352	5	also	also	RB
cord-016293-pyb00pt5	352	6	surrounded	surround	VBD
cord-016293-pyb00pt5	352	7	James	James	NNP
cord-016293-pyb00pt5	352	8	Wilson	Wilson	NNP
cord-016293-pyb00pt5	352	9	,	,	,
cord-016293-pyb00pt5	352	10	who	who	WP
cord-016293-pyb00pt5	352	11	stood	stand	VBD
cord-016293-pyb00pt5	352	12	to	to	TO
cord-016293-pyb00pt5	352	13	personally	personally	RB
cord-016293-pyb00pt5	352	14	profit	profit	VB
cord-016293-pyb00pt5	352	15	from	from	IN
cord-016293-pyb00pt5	352	16	the	the	DT
cord-016293-pyb00pt5	352	17	experiment	experiment	NN
cord-016293-pyb00pt5	352	18	through	through	IN
cord-016293-pyb00pt5	352	19	Genovo	Genovo	NNP
cord-016293-pyb00pt5	352	20	his	-PRON-	PRP$
cord-016293-pyb00pt5	352	21	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	352	22	company	company	NN
cord-016293-pyb00pt5	352	23	.	.	.
cord-016293-pyb00pt5	353	1	The	the	DT
cord-016293-pyb00pt5	353	2	lawsuit	lawsuit	NN
cord-016293-pyb00pt5	353	3	was	be	VBD
cord-016293-pyb00pt5	353	4	settled	settle	VBN
cord-016293-pyb00pt5	353	5	out	out	IN
cord-016293-pyb00pt5	353	6	of	of	IN
cord-016293-pyb00pt5	353	7	court	court	NN
cord-016293-pyb00pt5	353	8	for	for	IN
cord-016293-pyb00pt5	353	9	undisclosed	undisclosed	JJ
cord-016293-pyb00pt5	353	10	terms	term	NNS
cord-016293-pyb00pt5	353	11	in	in	IN
cord-016293-pyb00pt5	353	12	November	November	NNP
cord-016293-pyb00pt5	353	13	2000	2000	CD
cord-016293-pyb00pt5	353	14	.	.	.
cord-016293-pyb00pt5	354	1	The	the	DT
cord-016293-pyb00pt5	354	2	FDA	FDA	NNP
cord-016293-pyb00pt5	354	3	also	also	RB
cord-016293-pyb00pt5	354	4	suspended	suspend	VBD
cord-016293-pyb00pt5	354	5	gene	gene	NN
cord-016293-pyb00pt5	354	6	therapy	therapy	NN
cord-016293-pyb00pt5	354	7	trials	trial	NNS
cord-016293-pyb00pt5	354	8	at	at	IN
cord-016293-pyb00pt5	354	9	St.	St.	NNP
cord-016293-pyb00pt5	354	10	Elizabeth	Elizabeth	NNP
cord-016293-pyb00pt5	354	11	's	's	POS
cord-016293-pyb00pt5	354	12	Medical	Medical	NNP
cord-016293-pyb00pt5	354	13	Center	Center	NNP
cord-016293-pyb00pt5	354	14	in	in	IN
cord-016293-pyb00pt5	354	15	Boston	Boston	NNP
cord-016293-pyb00pt5	354	16	,	,	,
cord-016293-pyb00pt5	354	17	a	a	DT
cord-016293-pyb00pt5	354	18	major	major	JJ
cord-016293-pyb00pt5	354	19	teaching	teaching	NN
cord-016293-pyb00pt5	354	20	affiliate	affiliate	NN
cord-016293-pyb00pt5	354	21	of	of	IN
cord-016293-pyb00pt5	354	22	Tufts	Tufts	NNP
cord-016293-pyb00pt5	354	23	University	University	NNP
cord-016293-pyb00pt5	354	24	School	School	NNP
cord-016293-pyb00pt5	354	25	of	of	IN
cord-016293-pyb00pt5	354	26	Medicine	Medicine	NNP
cord-016293-pyb00pt5	354	27	,	,	,
cord-016293-pyb00pt5	354	28	which	which	WDT
cord-016293-pyb00pt5	354	29	sought	seek	VBD
cord-016293-pyb00pt5	354	30	to	to	TO
cord-016293-pyb00pt5	354	31	use	use	VB
cord-016293-pyb00pt5	354	32	gene	gene	NN
cord-016293-pyb00pt5	354	33	therapy	therapy	NN
cord-016293-pyb00pt5	354	34	to	to	TO
cord-016293-pyb00pt5	354	35	reverse	reverse	VB
cord-016293-pyb00pt5	354	36	heart	heart	NN
cord-016293-pyb00pt5	354	37	disease	disease	NN
cord-016293-pyb00pt5	354	38	,	,	,
cord-016293-pyb00pt5	354	39	because	because	IN
cord-016293-pyb00pt5	354	40	scientists	scientist	NNS
cord-016293-pyb00pt5	354	41	there	there	RB
cord-016293-pyb00pt5	354	42	failed	fail	VBD
cord-016293-pyb00pt5	354	43	to	to	TO
cord-016293-pyb00pt5	354	44	follow	follow	VB
cord-016293-pyb00pt5	354	45	protocols	protocol	NNS
cord-016293-pyb00pt5	354	46	and	and	CC
cord-016293-pyb00pt5	354	47	may	may	MD
cord-016293-pyb00pt5	354	48	have	have	VB
cord-016293-pyb00pt5	354	49	contributed	contribute	VBN
cord-016293-pyb00pt5	354	50	to	to	IN
cord-016293-pyb00pt5	354	51	at	at	RB
cord-016293-pyb00pt5	354	52	least	least	RBS
cord-016293-pyb00pt5	354	53	one	one	CD
cord-016293-pyb00pt5	354	54	patient	patient	JJ
cord-016293-pyb00pt5	354	55	death	death	NN
cord-016293-pyb00pt5	354	56	.	.	.
cord-016293-pyb00pt5	355	1	In	in	IN
cord-016293-pyb00pt5	355	2	addition	addition	NN
cord-016293-pyb00pt5	355	3	,	,	,
cord-016293-pyb00pt5	355	4	the	the	DT
cord-016293-pyb00pt5	355	5	FDA	FDA	NNP
cord-016293-pyb00pt5	355	6	temporarily	temporarily	RB
cord-016293-pyb00pt5	355	7	suspended	suspend	VBD
cord-016293-pyb00pt5	355	8	two	two	CD
cord-016293-pyb00pt5	355	9	liver	liver	NN
cord-016293-pyb00pt5	355	10	cancer	cancer	NN
cord-016293-pyb00pt5	355	11	studies	study	NNS
cord-016293-pyb00pt5	355	12	sponsored	sponsor	VBN
cord-016293-pyb00pt5	355	13	by	by	IN
cord-016293-pyb00pt5	355	14	the	the	DT
cord-016293-pyb00pt5	355	15	Schering	Schering	NNP
cord-016293-pyb00pt5	355	16	-	-	HYPH
cord-016293-pyb00pt5	355	17	Plough	Plough	NNP
cord-016293-pyb00pt5	355	18	Corporation	Corporation	NNP
cord-016293-pyb00pt5	355	19	because	because	IN
cord-016293-pyb00pt5	355	20	of	of	IN
cord-016293-pyb00pt5	355	21	technical	technical	JJ
cord-016293-pyb00pt5	355	22	similarities	similarity	NNS
cord-016293-pyb00pt5	355	23	to	to	IN
cord-016293-pyb00pt5	355	24	the	the	DT
cord-016293-pyb00pt5	355	25	University	University	NNP
cord-016293-pyb00pt5	355	26	of	of	IN
cord-016293-pyb00pt5	355	27	Pennsylvania	Pennsylvania	NNP
cord-016293-pyb00pt5	355	28	study	study	NN
cord-016293-pyb00pt5	355	29	.	.	.
cord-016293-pyb00pt5	356	1	Some	some	DT
cord-016293-pyb00pt5	356	2	research	research	NN
cord-016293-pyb00pt5	356	3	groups	group	NNS
cord-016293-pyb00pt5	356	4	voluntarily	voluntarily	RB
cord-016293-pyb00pt5	356	5	suspended	suspend	VBD
cord-016293-pyb00pt5	356	6	gene	gene	NN
cord-016293-pyb00pt5	356	7	therapy	therapy	NN
cord-016293-pyb00pt5	356	8	studies	study	NNS
cord-016293-pyb00pt5	356	9	,	,	,
cord-016293-pyb00pt5	356	10	including	include	VBG
cord-016293-pyb00pt5	356	11	two	two	CD
cord-016293-pyb00pt5	356	12	experiments	experiment	NNS
cord-016293-pyb00pt5	356	13	sponsored	sponsor	VBN
cord-016293-pyb00pt5	356	14	by	by	IN
cord-016293-pyb00pt5	356	15	the	the	DT
cord-016293-pyb00pt5	356	16	Cystic	Cystic	NNP
cord-016293-pyb00pt5	356	17	Fibrosis	Fibrosis	NNP
cord-016293-pyb00pt5	356	18	Foundation	Foundation	NNP
cord-016293-pyb00pt5	356	19	and	and	CC
cord-016293-pyb00pt5	356	20	studies	study	NNS
cord-016293-pyb00pt5	356	21	at	at	IN
cord-016293-pyb00pt5	356	22	Beth	Beth	NNP
cord-016293-pyb00pt5	356	23	Israel	Israel	NNP
cord-016293-pyb00pt5	356	24	Deaconess	Deaconess	NNP
cord-016293-pyb00pt5	356	25	Medical	Medical	NNP
cord-016293-pyb00pt5	356	26	Center	Center	NNP
cord-016293-pyb00pt5	356	27	in	in	IN
cord-016293-pyb00pt5	356	28	Boston	Boston	NNP
cord-016293-pyb00pt5	356	29	aimed	aim	VBN
cord-016293-pyb00pt5	356	30	at	at	IN
cord-016293-pyb00pt5	356	31	hemophilia	hemophilia	NN
cord-016293-pyb00pt5	356	32	.	.	.
cord-016293-pyb00pt5	357	1	The	the	DT
cord-016293-pyb00pt5	357	2	scientists	scientist	NNS
cord-016293-pyb00pt5	357	3	paused	pause	VBD
cord-016293-pyb00pt5	357	4	to	to	TO
cord-016293-pyb00pt5	357	5	make	make	VB
cord-016293-pyb00pt5	357	6	sure	sure	JJ
cord-016293-pyb00pt5	357	7	they	-PRON-	PRP
cord-016293-pyb00pt5	357	8	learned	learn	VBD
cord-016293-pyb00pt5	357	9	from	from	IN
cord-016293-pyb00pt5	357	10	the	the	DT
cord-016293-pyb00pt5	357	11	mistakes	mistake	NNS
cord-016293-pyb00pt5	357	12	.	.	.
cord-016293-pyb00pt5	358	1	The	the	DT
cord-016293-pyb00pt5	358	2	nineties	ninety	NNS
cord-016293-pyb00pt5	358	3	also	also	RB
cord-016293-pyb00pt5	358	4	saw	see	VBD
cord-016293-pyb00pt5	358	5	the	the	DT
cord-016293-pyb00pt5	358	6	development	development	NN
cord-016293-pyb00pt5	358	7	of	of	IN
cord-016293-pyb00pt5	358	8	another	another	DT
cord-016293-pyb00pt5	358	9	"	"	``
cord-016293-pyb00pt5	358	10	high	high	JJ
cord-016293-pyb00pt5	358	11	-	-	HYPH
cord-016293-pyb00pt5	358	12	thoughput	thoughput	NN
cord-016293-pyb00pt5	358	13	"	"	''
cord-016293-pyb00pt5	358	14	breakthrough	breakthrough	NN
cord-016293-pyb00pt5	358	15	,	,	,
cord-016293-pyb00pt5	358	16	a	a	DT
cord-016293-pyb00pt5	358	17	derivative	derivative	NN
cord-016293-pyb00pt5	358	18	of	of	IN
cord-016293-pyb00pt5	358	19	the	the	DT
cord-016293-pyb00pt5	358	20	other	other	JJ
cord-016293-pyb00pt5	358	21	high	high	JJ
cord-016293-pyb00pt5	358	22	tech	tech	NN
cord-016293-pyb00pt5	358	23	revolution	revolution	NN
cord-016293-pyb00pt5	358	24	namely	namely	RB
cord-016293-pyb00pt5	358	25	DNA	dna	NN
cord-016293-pyb00pt5	358	26	chips	chip	NNS
cord-016293-pyb00pt5	358	27	.	.	.
cord-016293-pyb00pt5	359	1	In	in	IN
cord-016293-pyb00pt5	359	2	1991	1991	CD
cord-016293-pyb00pt5	359	3	Biochips	Biochips	NNP
cord-016293-pyb00pt5	359	4	were	be	VBD
cord-016293-pyb00pt5	359	5	developed	develop	VBN
cord-016293-pyb00pt5	359	6	for	for	IN
cord-016293-pyb00pt5	359	7	commercial	commercial	JJ
cord-016293-pyb00pt5	359	8	use	use	NN
cord-016293-pyb00pt5	359	9	under	under	IN
cord-016293-pyb00pt5	359	10	the	the	DT
cord-016293-pyb00pt5	359	11	guidance	guidance	NN
cord-016293-pyb00pt5	359	12	of	of	IN
cord-016293-pyb00pt5	359	13	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	359	14	.	.	.
cord-016293-pyb00pt5	360	1	DNA	dna	NN
cord-016293-pyb00pt5	360	2	chips	chip	NNS
cord-016293-pyb00pt5	360	3	or	or	CC
cord-016293-pyb00pt5	360	4	microarrays	microarray	NNS
cord-016293-pyb00pt5	360	5	represent	represent	VBP
cord-016293-pyb00pt5	360	6	a	a	DT
cord-016293-pyb00pt5	360	7	"	"	``
cord-016293-pyb00pt5	360	8	massively	massively	RB
cord-016293-pyb00pt5	360	9	parallel	parallel	JJ
cord-016293-pyb00pt5	360	10	"	"	''
cord-016293-pyb00pt5	360	11	genomic	genomic	JJ
cord-016293-pyb00pt5	360	12	technology	technology	NN
cord-016293-pyb00pt5	360	13	.	.	.
cord-016293-pyb00pt5	361	1	They	-PRON-	PRP
cord-016293-pyb00pt5	361	2	facilitate	facilitate	VBP
cord-016293-pyb00pt5	361	3	high	high	JJ
cord-016293-pyb00pt5	361	4	throughput	throughput	NN
cord-016293-pyb00pt5	361	5	analysis	analysis	NN
cord-016293-pyb00pt5	361	6	of	of	IN
cord-016293-pyb00pt5	361	7	thousands	thousand	NNS
cord-016293-pyb00pt5	361	8	of	of	IN
cord-016293-pyb00pt5	361	9	genes	gene	NNS
cord-016293-pyb00pt5	361	10	simultaneously	simultaneously	RB
cord-016293-pyb00pt5	361	11	,	,	,
cord-016293-pyb00pt5	361	12	and	and	CC
cord-016293-pyb00pt5	361	13	are	be	VBP
cord-016293-pyb00pt5	361	14	thus	thus	RB
cord-016293-pyb00pt5	361	15	potentially	potentially	RB
cord-016293-pyb00pt5	361	16	very	very	RB
cord-016293-pyb00pt5	361	17	powerful	powerful	JJ
cord-016293-pyb00pt5	361	18	tools	tool	NNS
cord-016293-pyb00pt5	361	19	for	for	IN
cord-016293-pyb00pt5	361	20	gaining	gain	VBG
cord-016293-pyb00pt5	361	21	insight	insight	NN
cord-016293-pyb00pt5	361	22	into	into	IN
cord-016293-pyb00pt5	361	23	the	the	DT
cord-016293-pyb00pt5	361	24	complexities	complexity	NNS
cord-016293-pyb00pt5	361	25	of	of	IN
cord-016293-pyb00pt5	361	26	higher	high	JJR
cord-016293-pyb00pt5	361	27	organisms	organism	NNS
cord-016293-pyb00pt5	361	28	including	include	VBG
cord-016293-pyb00pt5	361	29	analysis	analysis	NN
cord-016293-pyb00pt5	361	30	of	of	IN
cord-016293-pyb00pt5	361	31	gene	gene	NN
cord-016293-pyb00pt5	361	32	expression	expression	NN
cord-016293-pyb00pt5	361	33	,	,	,
cord-016293-pyb00pt5	361	34	detecting	detect	VBG
cord-016293-pyb00pt5	361	35	genetic	genetic	JJ
cord-016293-pyb00pt5	361	36	variation	variation	NN
cord-016293-pyb00pt5	361	37	,	,	,
cord-016293-pyb00pt5	361	38	making	make	VBG
cord-016293-pyb00pt5	361	39	new	new	JJ
cord-016293-pyb00pt5	361	40	gene	gene	NN
cord-016293-pyb00pt5	361	41	discoveries	discovery	NNS
cord-016293-pyb00pt5	361	42	,	,	,
cord-016293-pyb00pt5	361	43	fingerprinting	fingerprinting	NN
cord-016293-pyb00pt5	361	44	strains	strain	NNS
cord-016293-pyb00pt5	361	45	and	and	CC
cord-016293-pyb00pt5	361	46	developing	develop	VBG
cord-016293-pyb00pt5	361	47	new	new	JJ
cord-016293-pyb00pt5	361	48	diagnostic	diagnostic	JJ
cord-016293-pyb00pt5	361	49	tools	tool	NNS
cord-016293-pyb00pt5	361	50	.	.	.
cord-016293-pyb00pt5	362	1	These	these	DT
cord-016293-pyb00pt5	362	2	technologies	technology	NNS
cord-016293-pyb00pt5	362	3	permit	permit	VBP
cord-016293-pyb00pt5	362	4	scientists	scientist	NNS
cord-016293-pyb00pt5	362	5	to	to	TO
cord-016293-pyb00pt5	362	6	conduct	conduct	VB
cord-016293-pyb00pt5	362	7	large	large	JJ
cord-016293-pyb00pt5	362	8	scale	scale	NN
cord-016293-pyb00pt5	362	9	surveys	survey	NNS
cord-016293-pyb00pt5	362	10	of	of	IN
cord-016293-pyb00pt5	362	11	gene	gene	NN
cord-016293-pyb00pt5	362	12	expression	expression	NN
cord-016293-pyb00pt5	362	13	in	in	IN
cord-016293-pyb00pt5	362	14	organisms	organism	NNS
cord-016293-pyb00pt5	362	15	,	,	,
cord-016293-pyb00pt5	362	16	thus	thus	RB
cord-016293-pyb00pt5	362	17	adding	add	VBG
cord-016293-pyb00pt5	362	18	to	to	IN
cord-016293-pyb00pt5	362	19	our	-PRON-	PRP$
cord-016293-pyb00pt5	362	20	knowledge	knowledge	NN
cord-016293-pyb00pt5	362	21	of	of	IN
cord-016293-pyb00pt5	362	22	how	how	WRB
cord-016293-pyb00pt5	362	23	they	-PRON-	PRP
cord-016293-pyb00pt5	362	24	develop	develop	VBP
cord-016293-pyb00pt5	362	25	over	over	IN
cord-016293-pyb00pt5	362	26	time	time	NN
cord-016293-pyb00pt5	362	27	or	or	CC
cord-016293-pyb00pt5	362	28	respond	respond	VB
cord-016293-pyb00pt5	362	29	to	to	IN
cord-016293-pyb00pt5	362	30	various	various	JJ
cord-016293-pyb00pt5	362	31	environmental	environmental	JJ
cord-016293-pyb00pt5	362	32	stimuli	stimulus	NNS
cord-016293-pyb00pt5	362	33	.	.	.
cord-016293-pyb00pt5	363	1	These	these	DT
cord-016293-pyb00pt5	363	2	techniques	technique	NNS
cord-016293-pyb00pt5	363	3	are	be	VBP
cord-016293-pyb00pt5	363	4	especially	especially	RB
cord-016293-pyb00pt5	363	5	useful	useful	JJ
cord-016293-pyb00pt5	363	6	in	in	IN
cord-016293-pyb00pt5	363	7	gaining	gain	VBG
cord-016293-pyb00pt5	363	8	an	an	DT
cord-016293-pyb00pt5	363	9	integrated	integrated	JJ
cord-016293-pyb00pt5	363	10	view	view	NN
cord-016293-pyb00pt5	363	11	of	of	IN
cord-016293-pyb00pt5	363	12	how	how	WRB
cord-016293-pyb00pt5	363	13	multiple	multiple	JJ
cord-016293-pyb00pt5	363	14	genes	gene	NNS
cord-016293-pyb00pt5	363	15	are	be	VBP
cord-016293-pyb00pt5	363	16	expressed	express	VBN
cord-016293-pyb00pt5	363	17	in	in	IN
cord-016293-pyb00pt5	363	18	a	a	DT
cord-016293-pyb00pt5	363	19	coordinated	coordinated	JJ
cord-016293-pyb00pt5	363	20	manner	manner	NN
cord-016293-pyb00pt5	363	21	.	.	.
cord-016293-pyb00pt5	364	1	These	these	DT
cord-016293-pyb00pt5	364	2	DNA	dna	NN
cord-016293-pyb00pt5	364	3	chips	chip	NNS
cord-016293-pyb00pt5	364	4	have	have	VBP
cord-016293-pyb00pt5	364	5	broad	broad	JJ
cord-016293-pyb00pt5	364	6	commercial	commercial	JJ
cord-016293-pyb00pt5	364	7	applications	application	NNS
cord-016293-pyb00pt5	364	8	and	and	CC
cord-016293-pyb00pt5	364	9	are	be	VBP
cord-016293-pyb00pt5	364	10	now	now	RB
cord-016293-pyb00pt5	364	11	used	use	VBN
cord-016293-pyb00pt5	364	12	in	in	IN
cord-016293-pyb00pt5	364	13	many	many	JJ
cord-016293-pyb00pt5	364	14	areas	area	NNS
cord-016293-pyb00pt5	364	15	of	of	IN
cord-016293-pyb00pt5	364	16	basic	basic	JJ
cord-016293-pyb00pt5	364	17	and	and	CC
cord-016293-pyb00pt5	364	18	clinical	clinical	JJ
cord-016293-pyb00pt5	364	19	research	research	NN
cord-016293-pyb00pt5	364	20	including	include	VBG
cord-016293-pyb00pt5	364	21	the	the	DT
cord-016293-pyb00pt5	364	22	detection	detection	NN
cord-016293-pyb00pt5	364	23	of	of	IN
cord-016293-pyb00pt5	364	24	drug	drug	NN
cord-016293-pyb00pt5	364	25	resistance	resistance	NN
cord-016293-pyb00pt5	364	26	mutations	mutation	NNS
cord-016293-pyb00pt5	364	27	in	in	IN
cord-016293-pyb00pt5	364	28	infectious	infectious	JJ
cord-016293-pyb00pt5	364	29	organisms	organism	NNS
cord-016293-pyb00pt5	364	30	,	,	,
cord-016293-pyb00pt5	364	31	direct	direct	JJ
cord-016293-pyb00pt5	364	32	DNA	dna	NN
cord-016293-pyb00pt5	364	33	sequence	sequence	NN
cord-016293-pyb00pt5	364	34	comparison	comparison	NN
cord-016293-pyb00pt5	364	35	of	of	IN
cord-016293-pyb00pt5	364	36	large	large	JJ
cord-016293-pyb00pt5	364	37	segments	segment	NNS
cord-016293-pyb00pt5	364	38	of	of	IN
cord-016293-pyb00pt5	364	39	the	the	DT
cord-016293-pyb00pt5	364	40	human	human	JJ
cord-016293-pyb00pt5	364	41	genome	genome	NN
cord-016293-pyb00pt5	364	42	,	,	,
cord-016293-pyb00pt5	364	43	the	the	DT
cord-016293-pyb00pt5	364	44	monitoring	monitoring	NN
cord-016293-pyb00pt5	364	45	of	of	IN
cord-016293-pyb00pt5	364	46	multiple	multiple	JJ
cord-016293-pyb00pt5	364	47	human	human	JJ
cord-016293-pyb00pt5	364	48	genes	gene	NNS
cord-016293-pyb00pt5	364	49	for	for	IN
cord-016293-pyb00pt5	364	50	disease	disease	NN
cord-016293-pyb00pt5	364	51	associated	associate	VBN
cord-016293-pyb00pt5	364	52	mutations	mutation	NNS
cord-016293-pyb00pt5	364	53	,	,	,
cord-016293-pyb00pt5	364	54	the	the	DT
cord-016293-pyb00pt5	364	55	quantitative	quantitative	JJ
cord-016293-pyb00pt5	364	56	and	and	CC
cord-016293-pyb00pt5	364	57	parallel	parallel	JJ
cord-016293-pyb00pt5	364	58	measurement	measurement	NN
cord-016293-pyb00pt5	364	59	of	of	IN
cord-016293-pyb00pt5	364	60	mRNA	mRNA	NNP
cord-016293-pyb00pt5	364	61	expression	expression	NN
cord-016293-pyb00pt5	364	62	for	for	IN
cord-016293-pyb00pt5	364	63	thousands	thousand	NNS
cord-016293-pyb00pt5	364	64	of	of	IN
cord-016293-pyb00pt5	364	65	human	human	JJ
cord-016293-pyb00pt5	364	66	genes	gene	NNS
cord-016293-pyb00pt5	364	67	,	,	,
cord-016293-pyb00pt5	364	68	and	and	CC
cord-016293-pyb00pt5	364	69	the	the	DT
cord-016293-pyb00pt5	364	70	physical	physical	JJ
cord-016293-pyb00pt5	364	71	and	and	CC
cord-016293-pyb00pt5	364	72	genetic	genetic	JJ
cord-016293-pyb00pt5	364	73	mapping	mapping	NN
cord-016293-pyb00pt5	364	74	of	of	IN
cord-016293-pyb00pt5	364	75	genomes	genome	NNS
cord-016293-pyb00pt5	364	76	.	.	.
cord-016293-pyb00pt5	365	1	However	however	RB
cord-016293-pyb00pt5	365	2	the	the	DT
cord-016293-pyb00pt5	365	3	initial	initial	JJ
cord-016293-pyb00pt5	365	4	technologies	technology	NNS
cord-016293-pyb00pt5	365	5	,	,	,
cord-016293-pyb00pt5	365	6	or	or	CC
cord-016293-pyb00pt5	365	7	more	more	RBR
cord-016293-pyb00pt5	365	8	accurately	accurately	RB
cord-016293-pyb00pt5	365	9	the	the	DT
cord-016293-pyb00pt5	365	10	algorithms	algorithm	NNS
cord-016293-pyb00pt5	365	11	used	use	VBD
cord-016293-pyb00pt5	365	12	to	to	TO
cord-016293-pyb00pt5	365	13	extract	extract	VB
cord-016293-pyb00pt5	365	14	information	information	NN
cord-016293-pyb00pt5	365	15	,	,	,
cord-016293-pyb00pt5	365	16	were	be	VBD
cord-016293-pyb00pt5	365	17	far	far	RB
cord-016293-pyb00pt5	365	18	from	from	IN
cord-016293-pyb00pt5	365	19	robust	robust	JJ
cord-016293-pyb00pt5	365	20	and	and	CC
cord-016293-pyb00pt5	365	21	reproducible	reproducible	JJ
cord-016293-pyb00pt5	365	22	.	.	.
cord-016293-pyb00pt5	366	1	The	the	DT
cord-016293-pyb00pt5	366	2	erstwhile	erstwhile	JJ
cord-016293-pyb00pt5	366	3	serial	serial	JJ
cord-016293-pyb00pt5	366	4	entrepreneur	entrepreneur	NN
cord-016293-pyb00pt5	366	5	,	,	,
cord-016293-pyb00pt5	366	6	Al	Al	NNP
cord-016293-pyb00pt5	366	7	Zaffaroni	Zaffaroni	NNP
cord-016293-pyb00pt5	366	8	(	(	-LRB-
cord-016293-pyb00pt5	366	9	the	the	DT
cord-016293-pyb00pt5	366	10	rebel	rebel	NN
cord-016293-pyb00pt5	366	11	who	who	WP
cord-016293-pyb00pt5	366	12	in	in	IN
cord-016293-pyb00pt5	366	13	1968	1968	CD
cord-016293-pyb00pt5	366	14	founded	found	VBD
cord-016293-pyb00pt5	366	15	Alza	Alza	NNP
cord-016293-pyb00pt5	366	16	when	when	WRB
cord-016293-pyb00pt5	366	17	Syntex	Syntex	NNP
cord-016293-pyb00pt5	366	18	ignored	ignore	VBD
cord-016293-pyb00pt5	366	19	his	-PRON-	PRP$
cord-016293-pyb00pt5	366	20	interest	interest	NN
cord-016293-pyb00pt5	366	21	in	in	IN
cord-016293-pyb00pt5	366	22	developing	develop	VBG
cord-016293-pyb00pt5	366	23	new	new	JJ
cord-016293-pyb00pt5	366	24	ways	way	NNS
cord-016293-pyb00pt5	366	25	to	to	TO
cord-016293-pyb00pt5	366	26	deliver	deliver	VB
cord-016293-pyb00pt5	366	27	drugs	drug	NNS
cord-016293-pyb00pt5	366	28	)	)	-RRB-
cord-016293-pyb00pt5	366	29	founded	found	VBN
cord-016293-pyb00pt5	366	30	yet	yet	RB
cord-016293-pyb00pt5	366	31	another	another	DT
cord-016293-pyb00pt5	366	32	company	company	NN
cord-016293-pyb00pt5	366	33	,	,	,
cord-016293-pyb00pt5	366	34	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	366	35	,	,	,
cord-016293-pyb00pt5	366	36	under	under	IN
cord-016293-pyb00pt5	366	37	the	the	DT
cord-016293-pyb00pt5	366	38	stewardship	stewardship	NN
cord-016293-pyb00pt5	366	39	of	of	IN
cord-016293-pyb00pt5	366	40	Stephen	Stephen	NNP
cord-016293-pyb00pt5	366	41	Fodor	Fodor	NNP
cord-016293-pyb00pt5	366	42	,	,	,
cord-016293-pyb00pt5	366	43	which	which	WDT
cord-016293-pyb00pt5	366	44	was	be	VBD
cord-016293-pyb00pt5	366	45	subject	subject	JJ
cord-016293-pyb00pt5	366	46	to	to	IN
cord-016293-pyb00pt5	366	47	much	much	JJ
cord-016293-pyb00pt5	366	48	abuse	abuse	NN
cord-016293-pyb00pt5	366	49	for	for	IN
cord-016293-pyb00pt5	366	50	providing	provide	VBG
cord-016293-pyb00pt5	366	51	final	final	JJ
cord-016293-pyb00pt5	366	52	extracted	extract	VBN
cord-016293-pyb00pt5	366	53	data	datum	NNS
cord-016293-pyb00pt5	366	54	and	and	CC
cord-016293-pyb00pt5	366	55	not	not	RB
cord-016293-pyb00pt5	366	56	allowing	allow	VBG
cord-016293-pyb00pt5	366	57	access	access	NN
cord-016293-pyb00pt5	366	58	to	to	IN
cord-016293-pyb00pt5	366	59	raw	raw	JJ
cord-016293-pyb00pt5	366	60	data	datum	NNS
cord-016293-pyb00pt5	366	61	.	.	.
cord-016293-pyb00pt5	367	1	As	as	IN
cord-016293-pyb00pt5	367	2	with	with	IN
cord-016293-pyb00pt5	367	3	other	other	JJ
cord-016293-pyb00pt5	367	4	personalities	personality	NNS
cord-016293-pyb00pt5	367	5	of	of	IN
cord-016293-pyb00pt5	367	6	this	this	DT
cord-016293-pyb00pt5	367	7	high	high	JJ
cord-016293-pyb00pt5	367	8	through	through	IN
cord-016293-pyb00pt5	367	9	put	put	NN
cord-016293-pyb00pt5	367	10	era	era	NN
cord-016293-pyb00pt5	367	11	,	,	,
cord-016293-pyb00pt5	367	12	Seattle	Seattle	NNP
cord-016293-pyb00pt5	367	13	-	-	HYPH
cord-016293-pyb00pt5	367	14	bred	breed	VBN
cord-016293-pyb00pt5	367	15	Steve	Steve	NNP
cord-016293-pyb00pt5	367	16	Fodor	Fodor	NNP
cord-016293-pyb00pt5	367	17	was	be	VBD
cord-016293-pyb00pt5	367	18	also	also	RB
cord-016293-pyb00pt5	367	19	somewhat	somewhat	RB
cord-016293-pyb00pt5	367	20	of	of	IN
cord-016293-pyb00pt5	367	21	a	a	DT
cord-016293-pyb00pt5	367	22	polymath	polymath	NN
cord-016293-pyb00pt5	367	23	having	have	VBG
cord-016293-pyb00pt5	367	24	contributed	contribute	VBN
cord-016293-pyb00pt5	367	25	to	to	IN
cord-016293-pyb00pt5	367	26	two	two	CD
cord-016293-pyb00pt5	367	27	major	major	JJ
cord-016293-pyb00pt5	367	28	technologies	technology	NNS
cord-016293-pyb00pt5	367	29	,	,	,
cord-016293-pyb00pt5	367	30	microarrays	microarray	NNS
cord-016293-pyb00pt5	367	31	and	and	CC
cord-016293-pyb00pt5	367	32	combinatorial	combinatorial	JJ
cord-016293-pyb00pt5	367	33	chemistry	chemistry	NN
cord-016293-pyb00pt5	367	34	,	,	,
cord-016293-pyb00pt5	367	35	the	the	DT
cord-016293-pyb00pt5	367	36	former	former	JJ
cord-016293-pyb00pt5	367	37	has	have	VBZ
cord-016293-pyb00pt5	367	38	delivered	deliver	VBN
cord-016293-pyb00pt5	367	39	on	on	IN
cord-016293-pyb00pt5	368	1	it	-PRON-	PRP
cord-016293-pyb00pt5	368	2	's	be	VBZ
cord-016293-pyb00pt5	368	3	,	,	,
cord-016293-pyb00pt5	368	4	promise	promise	VBP
cord-016293-pyb00pt5	368	5	while	while	IN
cord-016293-pyb00pt5	368	6	the	the	DT
cord-016293-pyb00pt5	368	7	latter	latter	JJ
cord-016293-pyb00pt5	368	8	,	,	,
cord-016293-pyb00pt5	368	9	like	like	IN
cord-016293-pyb00pt5	368	10	gene	gene	NN
cord-016293-pyb00pt5	368	11	therapy	therapy	NN
cord-016293-pyb00pt5	368	12	,	,	,
cord-016293-pyb00pt5	368	13	is	be	VBZ
cord-016293-pyb00pt5	368	14	still	still	RB
cord-016293-pyb00pt5	368	15	in	in	IN
cord-016293-pyb00pt5	368	16	a	a	DT
cord-016293-pyb00pt5	368	17	somewhat	somewhat	RB
cord-016293-pyb00pt5	368	18	extended	extended	JJ
cord-016293-pyb00pt5	368	19	gestation	gestation	NN
cord-016293-pyb00pt5	368	20	.	.	.
cord-016293-pyb00pt5	369	1	And	and	CC
cord-016293-pyb00pt5	369	2	despite	despite	IN
cord-016293-pyb00pt5	369	3	the	the	DT
cord-016293-pyb00pt5	369	4	limitations	limitation	NNS
cord-016293-pyb00pt5	369	5	of	of	IN
cord-016293-pyb00pt5	369	6	being	be	VBG
cord-016293-pyb00pt5	369	7	an	an	DT
cord-016293-pyb00pt5	369	8	industrial	industrial	JJ
cord-016293-pyb00pt5	369	9	scientist	scientist	NN
cord-016293-pyb00pt5	369	10	he	-PRON-	PRP
cord-016293-pyb00pt5	369	11	has	have	VBZ
cord-016293-pyb00pt5	369	12	had	have	VBN
cord-016293-pyb00pt5	369	13	a	a	DT
cord-016293-pyb00pt5	369	14	rather	rather	RB
cord-016293-pyb00pt5	369	15	prolific	prolific	JJ
cord-016293-pyb00pt5	369	16	portfolio	portfolio	NN
cord-016293-pyb00pt5	369	17	of	of	IN
cord-016293-pyb00pt5	369	18	publications	publication	NNS
cord-016293-pyb00pt5	369	19	.	.	.
cord-016293-pyb00pt5	370	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	370	2	seminal	seminal	JJ
cord-016293-pyb00pt5	370	3	manuscripts	manuscript	NNS
cord-016293-pyb00pt5	370	4	describing	describe	VBG
cord-016293-pyb00pt5	370	5	this	this	DT
cord-016293-pyb00pt5	370	6	work	work	NN
cord-016293-pyb00pt5	370	7	have	have	VBP
cord-016293-pyb00pt5	370	8	been	be	VBN
cord-016293-pyb00pt5	370	9	published	publish	VBN
cord-016293-pyb00pt5	370	10	in	in	IN
cord-016293-pyb00pt5	370	11	all	all	PDT
cord-016293-pyb00pt5	370	12	the	the	DT
cord-016293-pyb00pt5	370	13	journals	journal	NNS
cord-016293-pyb00pt5	370	14	of	of	IN
cord-016293-pyb00pt5	370	15	note	note	NN
cord-016293-pyb00pt5	370	16	,	,	,
cord-016293-pyb00pt5	370	17	Science	Science	NNP
cord-016293-pyb00pt5	370	18	,	,	,
cord-016293-pyb00pt5	370	19	Nature	Nature	NNP
cord-016293-pyb00pt5	370	20	and	and	CC
cord-016293-pyb00pt5	370	21	PNAS	PNAS	NNP
cord-016293-pyb00pt5	370	22	and	and	CC
cord-016293-pyb00pt5	370	23	was	be	VBD
cord-016293-pyb00pt5	370	24	recognized	recognize	VBN
cord-016293-pyb00pt5	370	25	in	in	IN
cord-016293-pyb00pt5	370	26	1992	1992	CD
cord-016293-pyb00pt5	370	27	by	by	IN
cord-016293-pyb00pt5	370	28	the	the	DT
cord-016293-pyb00pt5	370	29	AAAS	AAAS	NNP
cord-016293-pyb00pt5	370	30	by	by	IN
cord-016293-pyb00pt5	370	31	receiving	receive	VBG
cord-016293-pyb00pt5	370	32	the	the	DT
cord-016293-pyb00pt5	370	33	Newcomb	Newcomb	NNP
cord-016293-pyb00pt5	370	34	-	-	HYPH
cord-016293-pyb00pt5	370	35	Cleveland	Cleveland	NNP
cord-016293-pyb00pt5	370	36	Award	Award	NNP
cord-016293-pyb00pt5	370	37	for	for	IN
cord-016293-pyb00pt5	370	38	an	an	DT
cord-016293-pyb00pt5	370	39	outstanding	outstanding	JJ
cord-016293-pyb00pt5	370	40	paper	paper	NN
cord-016293-pyb00pt5	370	41	published	publish	VBN
cord-016293-pyb00pt5	370	42	in	in	IN
cord-016293-pyb00pt5	370	43	Science	Science	NNP
cord-016293-pyb00pt5	370	44	.	.	.
cord-016293-pyb00pt5	371	1	Fodor	Fodor	NNP
cord-016293-pyb00pt5	371	2	began	begin	VBD
cord-016293-pyb00pt5	371	3	his	-PRON-	PRP$
cord-016293-pyb00pt5	371	4	industrial	industrial	JJ
cord-016293-pyb00pt5	371	5	career	career	NN
cord-016293-pyb00pt5	371	6	in	in	IN
cord-016293-pyb00pt5	371	7	yet	yet	RB
cord-016293-pyb00pt5	371	8	another	another	DT
cord-016293-pyb00pt5	371	9	Zaffaroni	Zaffaroni	NNP
cord-016293-pyb00pt5	371	10	firm	firm	NN
cord-016293-pyb00pt5	371	11	.	.	.
cord-016293-pyb00pt5	372	1	In	in	IN
cord-016293-pyb00pt5	372	2	1989	1989	CD
cord-016293-pyb00pt5	372	3	he	-PRON-	PRP
cord-016293-pyb00pt5	372	4	was	be	VBD
cord-016293-pyb00pt5	372	5	recruited	recruit	VBN
cord-016293-pyb00pt5	372	6	to	to	IN
cord-016293-pyb00pt5	372	7	the	the	DT
cord-016293-pyb00pt5	372	8	Affymax	Affymax	NNP
cord-016293-pyb00pt5	372	9	Research	Research	NNP
cord-016293-pyb00pt5	372	10	Institute	Institute	NNP
cord-016293-pyb00pt5	372	11	in	in	IN
cord-016293-pyb00pt5	372	12	Palo	Palo	NNP
cord-016293-pyb00pt5	372	13	Alto	Alto	NNP
cord-016293-pyb00pt5	372	14	where	where	WRB
cord-016293-pyb00pt5	372	15	he	-PRON-	PRP
cord-016293-pyb00pt5	372	16	spearheaded	spearhead	VBD
cord-016293-pyb00pt5	372	17	the	the	DT
cord-016293-pyb00pt5	372	18	effort	effort	NN
cord-016293-pyb00pt5	372	19	to	to	TO
cord-016293-pyb00pt5	372	20	develop	develop	VB
cord-016293-pyb00pt5	372	21	high	high	JJ
cord-016293-pyb00pt5	372	22	-	-	HYPH
cord-016293-pyb00pt5	372	23	density	density	NN
cord-016293-pyb00pt5	372	24	arrays	array	NNS
cord-016293-pyb00pt5	372	25	of	of	IN
cord-016293-pyb00pt5	372	26	biological	biological	JJ
cord-016293-pyb00pt5	372	27	compounds	compound	NNS
cord-016293-pyb00pt5	372	28	.	.	.
cord-016293-pyb00pt5	373	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	373	2	initial	initial	JJ
cord-016293-pyb00pt5	373	3	interest	interest	NN
cord-016293-pyb00pt5	373	4	was	be	VBD
cord-016293-pyb00pt5	373	5	in	in	IN
cord-016293-pyb00pt5	373	6	the	the	DT
cord-016293-pyb00pt5	373	7	broad	broad	JJ
cord-016293-pyb00pt5	373	8	area	area	NN
cord-016293-pyb00pt5	373	9	of	of	IN
cord-016293-pyb00pt5	373	10	what	what	WP
cord-016293-pyb00pt5	373	11	came	come	VBD
cord-016293-pyb00pt5	373	12	to	to	TO
cord-016293-pyb00pt5	373	13	be	be	VB
cord-016293-pyb00pt5	373	14	called	call	VBN
cord-016293-pyb00pt5	373	15	combinatorial	combinatorial	JJ
cord-016293-pyb00pt5	373	16	chemistry	chemistry	NN
cord-016293-pyb00pt5	373	17	.	.	.
cord-016293-pyb00pt5	374	1	Of	of	IN
cord-016293-pyb00pt5	374	2	the	the	DT
cord-016293-pyb00pt5	374	3	techniques	technique	NNS
cord-016293-pyb00pt5	374	4	developed	develop	VBN
cord-016293-pyb00pt5	374	5	,	,	,
cord-016293-pyb00pt5	374	6	one	one	CD
cord-016293-pyb00pt5	374	7	approach	approach	NN
cord-016293-pyb00pt5	374	8	permitted	permit	VBD
cord-016293-pyb00pt5	374	9	high	high	JJ
cord-016293-pyb00pt5	374	10	resolution	resolution	NN
cord-016293-pyb00pt5	374	11	chemical	chemical	NN
cord-016293-pyb00pt5	374	12	synthesis	synthesis	NN
cord-016293-pyb00pt5	374	13	in	in	IN
cord-016293-pyb00pt5	374	14	a	a	DT
cord-016293-pyb00pt5	374	15	light	light	NN
cord-016293-pyb00pt5	374	16	-	-	HYPH
cord-016293-pyb00pt5	374	17	directed	direct	VBN
cord-016293-pyb00pt5	374	18	,	,	,
cord-016293-pyb00pt5	374	19	spatially	spatially	RB
cord-016293-pyb00pt5	374	20	-	-	HYPH
cord-016293-pyb00pt5	374	21	defined	define	VBN
cord-016293-pyb00pt5	374	22	format	format	NN
cord-016293-pyb00pt5	374	23	.	.	.
cord-016293-pyb00pt5	375	1	In	in	IN
cord-016293-pyb00pt5	375	2	the	the	DT
cord-016293-pyb00pt5	375	3	days	day	NNS
cord-016293-pyb00pt5	375	4	before	before	IN
cord-016293-pyb00pt5	375	5	positive	positive	JJ
cord-016293-pyb00pt5	375	6	selection	selection	NN
cord-016293-pyb00pt5	375	7	vectors	vector	NNS
cord-016293-pyb00pt5	375	8	,	,	,
cord-016293-pyb00pt5	375	9	a	a	DT
cord-016293-pyb00pt5	375	10	researcher	researcher	NN
cord-016293-pyb00pt5	375	11	might	may	MD
cord-016293-pyb00pt5	375	12	have	have	VB
cord-016293-pyb00pt5	375	13	screened	screen	VBN
cord-016293-pyb00pt5	375	14	thousands	thousand	NNS
cord-016293-pyb00pt5	375	15	of	of	IN
cord-016293-pyb00pt5	375	16	clones	clone	NNS
cord-016293-pyb00pt5	375	17	by	by	IN
cord-016293-pyb00pt5	375	18	hand	hand	NN
cord-016293-pyb00pt5	375	19	with	with	IN
cord-016293-pyb00pt5	375	20	an	an	DT
cord-016293-pyb00pt5	375	21	oligonucleotide	oligonucleotide	JJ
cord-016293-pyb00pt5	375	22	probe	probe	NN
cord-016293-pyb00pt5	375	23	just	just	RB
cord-016293-pyb00pt5	375	24	to	to	TO
cord-016293-pyb00pt5	375	25	find	find	VB
cord-016293-pyb00pt5	375	26	one	one	CD
cord-016293-pyb00pt5	375	27	elusive	elusive	JJ
cord-016293-pyb00pt5	375	28	insert	insert	NN
cord-016293-pyb00pt5	375	29	.	.	.
cord-016293-pyb00pt5	376	1	Fodor	Fodor	NNP
cord-016293-pyb00pt5	376	2	's	's	POS
cord-016293-pyb00pt5	376	3	(	(	-LRB-
cord-016293-pyb00pt5	376	4	and	and	CC
cord-016293-pyb00pt5	376	5	his	-PRON-	PRP$
cord-016293-pyb00pt5	376	6	successors	successor	NNS
cord-016293-pyb00pt5	376	7	)	)	-RRB-
cord-016293-pyb00pt5	376	8	DNA	dna	NN
cord-016293-pyb00pt5	376	9	array	array	NN
cord-016293-pyb00pt5	376	10	technology	technology	NN
cord-016293-pyb00pt5	376	11	reverses	reverse	VBZ
cord-016293-pyb00pt5	376	12	that	that	DT
cord-016293-pyb00pt5	376	13	approach	approach	NN
cord-016293-pyb00pt5	376	14	.	.	.
cord-016293-pyb00pt5	377	1	Instead	instead	RB
cord-016293-pyb00pt5	377	2	of	of	IN
cord-016293-pyb00pt5	377	3	screening	screen	VBG
cord-016293-pyb00pt5	377	4	an	an	DT
cord-016293-pyb00pt5	377	5	array	array	NN
cord-016293-pyb00pt5	377	6	of	of	IN
cord-016293-pyb00pt5	377	7	unknowns	unknown	NNS
cord-016293-pyb00pt5	377	8	with	with	IN
cord-016293-pyb00pt5	377	9	a	a	DT
cord-016293-pyb00pt5	377	10	defined	define	VBN
cord-016293-pyb00pt5	377	11	probe	probe	NN
cord-016293-pyb00pt5	377	12	-a	-a	HYPH
cord-016293-pyb00pt5	377	13	cloned	clone	VBN
cord-016293-pyb00pt5	377	14	gene	gene	NN
cord-016293-pyb00pt5	377	15	,	,	,
cord-016293-pyb00pt5	377	16	PCR	PCR	NNP
cord-016293-pyb00pt5	377	17	product	product	NN
cord-016293-pyb00pt5	377	18	,	,	,
cord-016293-pyb00pt5	377	19	or	or	CC
cord-016293-pyb00pt5	377	20	synthetic	synthetic	JJ
cord-016293-pyb00pt5	377	21	oligonucleotide	oligonucleotide	JJ
cord-016293-pyb00pt5	377	22	-each	-each	NN
cord-016293-pyb00pt5	377	23	position	position	NN
cord-016293-pyb00pt5	377	24	or	or	CC
cord-016293-pyb00pt5	377	25	"	"	``
cord-016293-pyb00pt5	377	26	probe	probe	NN
cord-016293-pyb00pt5	377	27	cell	cell	NN
cord-016293-pyb00pt5	377	28	"	"	''
cord-016293-pyb00pt5	377	29	in	in	IN
cord-016293-pyb00pt5	377	30	the	the	DT
cord-016293-pyb00pt5	377	31	array	array	NN
cord-016293-pyb00pt5	377	32	is	be	VBZ
cord-016293-pyb00pt5	377	33	occupied	occupy	VBN
cord-016293-pyb00pt5	377	34	by	by	IN
cord-016293-pyb00pt5	377	35	a	a	DT
cord-016293-pyb00pt5	377	36	defined	define	VBN
cord-016293-pyb00pt5	377	37	DNA	dna	NN
cord-016293-pyb00pt5	377	38	fragment	fragment	NN
cord-016293-pyb00pt5	377	39	,	,	,
cord-016293-pyb00pt5	377	40	and	and	CC
cord-016293-pyb00pt5	377	41	the	the	DT
cord-016293-pyb00pt5	377	42	array	array	NN
cord-016293-pyb00pt5	377	43	is	be	VBZ
cord-016293-pyb00pt5	377	44	probed	probe	VBN
cord-016293-pyb00pt5	377	45	with	with	IN
cord-016293-pyb00pt5	377	46	the	the	DT
cord-016293-pyb00pt5	377	47	unknown	unknown	JJ
cord-016293-pyb00pt5	377	48	sample	sample	NN
cord-016293-pyb00pt5	377	49	.	.	.
cord-016293-pyb00pt5	378	1	Fodor	Fodor	NNP
cord-016293-pyb00pt5	378	2	used	use	VBD
cord-016293-pyb00pt5	378	3	his	-PRON-	PRP$
cord-016293-pyb00pt5	378	4	chemistry	chemistry	NN
cord-016293-pyb00pt5	378	5	and	and	CC
cord-016293-pyb00pt5	378	6	biophysics	biophysic	NNS
cord-016293-pyb00pt5	378	7	background	background	VBP
cord-016293-pyb00pt5	378	8	to	to	TO
cord-016293-pyb00pt5	378	9	develop	develop	VB
cord-016293-pyb00pt5	378	10	very	very	RB
cord-016293-pyb00pt5	378	11	dense	dense	JJ
cord-016293-pyb00pt5	378	12	arrays	array	NNS
cord-016293-pyb00pt5	378	13	of	of	IN
cord-016293-pyb00pt5	378	14	these	these	DT
cord-016293-pyb00pt5	378	15	biomolecules	biomolecule	NNS
cord-016293-pyb00pt5	378	16	by	by	IN
cord-016293-pyb00pt5	378	17	combining	combine	VBG
cord-016293-pyb00pt5	378	18	photolithographic	photolithographic	JJ
cord-016293-pyb00pt5	378	19	methods	method	NNS
cord-016293-pyb00pt5	378	20	with	with	IN
cord-016293-pyb00pt5	378	21	traditional	traditional	JJ
cord-016293-pyb00pt5	378	22	chemical	chemical	NN
cord-016293-pyb00pt5	378	23	techniques	technique	NNS
cord-016293-pyb00pt5	378	24	.	.	.
cord-016293-pyb00pt5	379	1	The	the	DT
cord-016293-pyb00pt5	379	2	typical	typical	JJ
cord-016293-pyb00pt5	379	3	array	array	NN
cord-016293-pyb00pt5	379	4	may	may	MD
cord-016293-pyb00pt5	379	5	contain	contain	VB
cord-016293-pyb00pt5	379	6	all	all	DT
cord-016293-pyb00pt5	379	7	possible	possible	JJ
cord-016293-pyb00pt5	379	8	combinations	combination	NNS
cord-016293-pyb00pt5	379	9	of	of	IN
cord-016293-pyb00pt5	379	10	all	all	DT
cord-016293-pyb00pt5	379	11	possible	possible	JJ
cord-016293-pyb00pt5	379	12	oligonucleotides	oligonucleotide	NNS
cord-016293-pyb00pt5	379	13	(	(	-LRB-
cord-016293-pyb00pt5	379	14	8-mers	8-mers	CD
cord-016293-pyb00pt5	379	15	,	,	,
cord-016293-pyb00pt5	379	16	for	for	IN
cord-016293-pyb00pt5	379	17	example	example	NN
cord-016293-pyb00pt5	379	18	)	)	-RRB-
cord-016293-pyb00pt5	379	19	that	that	WDT
cord-016293-pyb00pt5	379	20	occur	occur	VBP
cord-016293-pyb00pt5	379	21	as	as	IN
cord-016293-pyb00pt5	379	22	a	a	DT
cord-016293-pyb00pt5	379	23	"	"	``
cord-016293-pyb00pt5	379	24	window	window	NN
cord-016293-pyb00pt5	379	25	"	"	''
cord-016293-pyb00pt5	379	26	which	which	WDT
cord-016293-pyb00pt5	379	27	is	be	VBZ
cord-016293-pyb00pt5	379	28	tracked	track	VBN
cord-016293-pyb00pt5	379	29	along	along	IN
cord-016293-pyb00pt5	379	30	a	a	DT
cord-016293-pyb00pt5	379	31	DNA	dna	NN
cord-016293-pyb00pt5	379	32	sequence	sequence	NN
cord-016293-pyb00pt5	379	33	.	.	.
cord-016293-pyb00pt5	380	1	It	-PRON-	PRP
cord-016293-pyb00pt5	380	2	might	may	MD
cord-016293-pyb00pt5	380	3	contain	contain	VB
cord-016293-pyb00pt5	380	4	longer	long	JJR
cord-016293-pyb00pt5	380	5	oligonucleotides	oligonucleotide	NNS
cord-016293-pyb00pt5	380	6	designed	design	VBN
cord-016293-pyb00pt5	380	7	from	from	IN
cord-016293-pyb00pt5	380	8	all	all	PDT
cord-016293-pyb00pt5	380	9	the	the	DT
cord-016293-pyb00pt5	380	10	open	open	JJ
cord-016293-pyb00pt5	380	11	reading	reading	NN
cord-016293-pyb00pt5	380	12	frames	frame	NNS
cord-016293-pyb00pt5	380	13	identified	identify	VBN
cord-016293-pyb00pt5	380	14	from	from	IN
cord-016293-pyb00pt5	380	15	a	a	DT
cord-016293-pyb00pt5	380	16	complete	complete	JJ
cord-016293-pyb00pt5	380	17	genome	genome	NN
cord-016293-pyb00pt5	380	18	sequence	sequence	NN
cord-016293-pyb00pt5	380	19	.	.	.
cord-016293-pyb00pt5	381	1	Or	or	CC
cord-016293-pyb00pt5	381	2	it	-PRON-	PRP
cord-016293-pyb00pt5	381	3	might	may	MD
cord-016293-pyb00pt5	381	4	contain	contain	VB
cord-016293-pyb00pt5	381	5	cDNAs	cDNAs	NNPS
cord-016293-pyb00pt5	381	6	-of	-of	ADD
cord-016293-pyb00pt5	381	7	known	know	VBN
cord-016293-pyb00pt5	381	8	or	or	CC
cord-016293-pyb00pt5	381	9	unknown	unknown	JJ
cord-016293-pyb00pt5	381	10	sequence	sequence	NN
cord-016293-pyb00pt5	381	11	-or	-or	:
cord-016293-pyb00pt5	381	12	PCR	PCR	NNP
cord-016293-pyb00pt5	381	13	products	product	NNS
cord-016293-pyb00pt5	381	14	.	.	.
cord-016293-pyb00pt5	382	1	Of	of	RB
cord-016293-pyb00pt5	382	2	course	course	RB
cord-016293-pyb00pt5	382	3	it	-PRON-	PRP
cord-016293-pyb00pt5	382	4	is	be	VBZ
cord-016293-pyb00pt5	382	5	one	one	CD
cord-016293-pyb00pt5	382	6	thing	thing	NN
cord-016293-pyb00pt5	382	7	to	to	TO
cord-016293-pyb00pt5	382	8	produce	produce	VB
cord-016293-pyb00pt5	382	9	data	datum	NNS
cord-016293-pyb00pt5	383	1	it	-PRON-	PRP
cord-016293-pyb00pt5	383	2	is	be	VBZ
cord-016293-pyb00pt5	383	3	quite	quite	PDT
cord-016293-pyb00pt5	383	4	another	another	DT
cord-016293-pyb00pt5	383	5	to	to	TO
cord-016293-pyb00pt5	383	6	extract	extract	VB
cord-016293-pyb00pt5	383	7	it	-PRON-	PRP
cord-016293-pyb00pt5	383	8	in	in	IN
cord-016293-pyb00pt5	383	9	a	a	DT
cord-016293-pyb00pt5	383	10	meaningful	meaningful	JJ
cord-016293-pyb00pt5	383	11	manner	manner	NN
cord-016293-pyb00pt5	383	12	.	.	.
cord-016293-pyb00pt5	384	1	Fodor	Fodor	NNP
cord-016293-pyb00pt5	384	2	's	's	POS
cord-016293-pyb00pt5	384	3	group	group	NN
cord-016293-pyb00pt5	384	4	also	also	RB
cord-016293-pyb00pt5	384	5	developed	develop	VBD
cord-016293-pyb00pt5	384	6	techniques	technique	NNS
cord-016293-pyb00pt5	384	7	to	to	TO
cord-016293-pyb00pt5	384	8	read	read	VB
cord-016293-pyb00pt5	384	9	these	these	DT
cord-016293-pyb00pt5	384	10	arrays	array	NNS
cord-016293-pyb00pt5	384	11	,	,	,
cord-016293-pyb00pt5	384	12	employing	employ	VBG
cord-016293-pyb00pt5	384	13	fluorescent	fluorescent	JJ
cord-016293-pyb00pt5	384	14	labeling	labeling	NN
cord-016293-pyb00pt5	384	15	methods	method	NNS
cord-016293-pyb00pt5	384	16	and	and	CC
cord-016293-pyb00pt5	384	17	confocal	confocal	JJ
cord-016293-pyb00pt5	384	18	laser	laser	NN
cord-016293-pyb00pt5	384	19	scanning	scanning	NN
cord-016293-pyb00pt5	384	20	to	to	TO
cord-016293-pyb00pt5	384	21	measure	measure	VB
cord-016293-pyb00pt5	384	22	each	each	DT
cord-016293-pyb00pt5	384	23	individual	individual	JJ
cord-016293-pyb00pt5	384	24	binding	bind	VBG
cord-016293-pyb00pt5	384	25	event	event	NN
cord-016293-pyb00pt5	384	26	on	on	IN
cord-016293-pyb00pt5	384	27	the	the	DT
cord-016293-pyb00pt5	384	28	surface	surface	NN
cord-016293-pyb00pt5	384	29	of	of	IN
cord-016293-pyb00pt5	384	30	the	the	DT
cord-016293-pyb00pt5	384	31	chip	chip	NN
cord-016293-pyb00pt5	384	32	with	with	IN
cord-016293-pyb00pt5	384	33	extraordinary	extraordinary	JJ
cord-016293-pyb00pt5	384	34	sensitivity	sensitivity	NN
cord-016293-pyb00pt5	384	35	and	and	CC
cord-016293-pyb00pt5	384	36	precision	precision	NN
cord-016293-pyb00pt5	384	37	.	.	.
cord-016293-pyb00pt5	385	1	This	this	DT
cord-016293-pyb00pt5	385	2	general	general	JJ
cord-016293-pyb00pt5	385	3	platform	platform	NN
cord-016293-pyb00pt5	385	4	of	of	IN
cord-016293-pyb00pt5	385	5	microarray	microarray	NN
cord-016293-pyb00pt5	385	6	based	base	VBN
cord-016293-pyb00pt5	385	7	analysis	analysis	NN
cord-016293-pyb00pt5	385	8	coupled	couple	VBN
cord-016293-pyb00pt5	385	9	to	to	IN
cord-016293-pyb00pt5	385	10	confocal	confocal	JJ
cord-016293-pyb00pt5	385	11	laser	laser	NN
cord-016293-pyb00pt5	385	12	scanning	scanning	NN
cord-016293-pyb00pt5	385	13	has	have	VBZ
cord-016293-pyb00pt5	385	14	become	become	VBN
cord-016293-pyb00pt5	385	15	the	the	DT
cord-016293-pyb00pt5	385	16	standard	standard	NN
cord-016293-pyb00pt5	385	17	in	in	IN
cord-016293-pyb00pt5	385	18	industry	industry	NN
cord-016293-pyb00pt5	385	19	and	and	CC
cord-016293-pyb00pt5	385	20	academia	academia	NN
cord-016293-pyb00pt5	385	21	for	for	IN
cord-016293-pyb00pt5	385	22	large	large	JJ
cord-016293-pyb00pt5	385	23	-	-	HYPH
cord-016293-pyb00pt5	385	24	scale	scale	NN
cord-016293-pyb00pt5	385	25	genomics	genomic	NNS
cord-016293-pyb00pt5	385	26	studies	study	NNS
cord-016293-pyb00pt5	385	27	.	.	.
cord-016293-pyb00pt5	386	1	In	in	IN
cord-016293-pyb00pt5	386	2	1993	1993	CD
cord-016293-pyb00pt5	386	3	,	,	,
cord-016293-pyb00pt5	386	4	Fodor	Fodor	NNP
cord-016293-pyb00pt5	386	5	co	co	VBD
cord-016293-pyb00pt5	386	6	-	-	VBD
cord-016293-pyb00pt5	386	7	founded	found	VBN
cord-016293-pyb00pt5	386	8	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	386	9	where	where	WRB
cord-016293-pyb00pt5	386	10	the	the	DT
cord-016293-pyb00pt5	386	11	chip	chip	NN
cord-016293-pyb00pt5	386	12	technology	technology	NN
cord-016293-pyb00pt5	386	13	has	have	VBZ
cord-016293-pyb00pt5	386	14	been	be	VBN
cord-016293-pyb00pt5	386	15	used	use	VBN
cord-016293-pyb00pt5	386	16	to	to	TO
cord-016293-pyb00pt5	386	17	synthesize	synthesize	VB
cord-016293-pyb00pt5	386	18	many	many	JJ
cord-016293-pyb00pt5	386	19	varieties	variety	NNS
cord-016293-pyb00pt5	386	20	of	of	IN
cord-016293-pyb00pt5	386	21	high	high	JJ
cord-016293-pyb00pt5	386	22	density	density	NN
cord-016293-pyb00pt5	386	23	oligonucleotide	oligonucleotide	NN
cord-016293-pyb00pt5	386	24	arrays	array	NNS
cord-016293-pyb00pt5	386	25	containing	contain	VBG
cord-016293-pyb00pt5	386	26	hundreds	hundred	NNS
cord-016293-pyb00pt5	386	27	of	of	IN
cord-016293-pyb00pt5	386	28	thousands	thousand	NNS
cord-016293-pyb00pt5	386	29	of	of	IN
cord-016293-pyb00pt5	386	30	DNA	dna	NN
cord-016293-pyb00pt5	386	31	probes	probe	NNS
cord-016293-pyb00pt5	386	32	.	.	.
cord-016293-pyb00pt5	387	1	In	in	IN
cord-016293-pyb00pt5	387	2	2001	2001	CD
cord-016293-pyb00pt5	387	3	,	,	,
cord-016293-pyb00pt5	387	4	Steve	Steve	NNP
cord-016293-pyb00pt5	387	5	Fodor	Fodor	NNP
cord-016293-pyb00pt5	387	6	founded	found	VBD
cord-016293-pyb00pt5	387	7	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	387	8	,	,	,
cord-016293-pyb00pt5	387	9	Inc.	Inc.	NNP
cord-016293-pyb00pt5	387	10	,	,	,
cord-016293-pyb00pt5	387	11	a	a	DT
cord-016293-pyb00pt5	387	12	new	new	JJ
cord-016293-pyb00pt5	387	13	venture	venture	NN
cord-016293-pyb00pt5	387	14	that	that	WDT
cord-016293-pyb00pt5	387	15	applied	apply	VBD
cord-016293-pyb00pt5	387	16	the	the	DT
cord-016293-pyb00pt5	387	17	chip	chip	NN
cord-016293-pyb00pt5	387	18	technology	technology	NN
cord-016293-pyb00pt5	387	19	towards	towards	IN
cord-016293-pyb00pt5	387	20	uncovering	uncover	VBG
cord-016293-pyb00pt5	387	21	the	the	DT
cord-016293-pyb00pt5	387	22	basic	basic	JJ
cord-016293-pyb00pt5	387	23	patterns	pattern	NNS
cord-016293-pyb00pt5	387	24	of	of	IN
cord-016293-pyb00pt5	387	25	human	human	JJ
cord-016293-pyb00pt5	387	26	diversity	diversity	NN
cord-016293-pyb00pt5	387	27	.	.	.
cord-016293-pyb00pt5	388	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	388	2	company	company	NN
cord-016293-pyb00pt5	388	3	's	's	POS
cord-016293-pyb00pt5	388	4	stated	state	VBN
cord-016293-pyb00pt5	388	5	goals	goal	NNS
cord-016293-pyb00pt5	388	6	are	be	VBP
cord-016293-pyb00pt5	388	7	to	to	TO
cord-016293-pyb00pt5	388	8	analyze	analyze	VB
cord-016293-pyb00pt5	388	9	more	more	JJR
cord-016293-pyb00pt5	388	10	than	than	IN
cord-016293-pyb00pt5	388	11	one	one	CD
cord-016293-pyb00pt5	388	12	million	million	CD
cord-016293-pyb00pt5	388	13	genetic	genetic	JJ
cord-016293-pyb00pt5	388	14	variations	variation	NNS
cord-016293-pyb00pt5	388	15	in	in	IN
cord-016293-pyb00pt5	388	16	clinical	clinical	JJ
cord-016293-pyb00pt5	388	17	trial	trial	NN
cord-016293-pyb00pt5	388	18	participants	participant	NNS
cord-016293-pyb00pt5	388	19	to	to	TO
cord-016293-pyb00pt5	388	20	explain	explain	VB
cord-016293-pyb00pt5	388	21	and	and	CC
cord-016293-pyb00pt5	388	22	predict	predict	VB
cord-016293-pyb00pt5	388	23	the	the	DT
cord-016293-pyb00pt5	388	24	efficacy	efficacy	NN
cord-016293-pyb00pt5	388	25	and	and	CC
cord-016293-pyb00pt5	388	26	adverse	adverse	JJ
cord-016293-pyb00pt5	388	27	effect	effect	NN
cord-016293-pyb00pt5	388	28	profiles	profile	NNS
cord-016293-pyb00pt5	388	29	of	of	IN
cord-016293-pyb00pt5	388	30	prescription	prescription	NN
cord-016293-pyb00pt5	388	31	drugs	drug	NNS
cord-016293-pyb00pt5	388	32	.	.	.
cord-016293-pyb00pt5	389	1	In	in	IN
cord-016293-pyb00pt5	389	2	addition	addition	NN
cord-016293-pyb00pt5	389	3	,	,	,
cord-016293-pyb00pt5	389	4	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	389	5	also	also	RB
cord-016293-pyb00pt5	389	6	applies	apply	VBZ
cord-016293-pyb00pt5	389	7	this	this	DT
cord-016293-pyb00pt5	389	8	expertise	expertise	NN
cord-016293-pyb00pt5	389	9	to	to	IN
cord-016293-pyb00pt5	389	10	discovering	discover	VBG
cord-016293-pyb00pt5	389	11	genetic	genetic	JJ
cord-016293-pyb00pt5	389	12	variants	variant	NNS
cord-016293-pyb00pt5	389	13	associated	associate	VBN
cord-016293-pyb00pt5	389	14	with	with	IN
cord-016293-pyb00pt5	389	15	disease	disease	NN
cord-016293-pyb00pt5	389	16	in	in	IN
cord-016293-pyb00pt5	389	17	order	order	NN
cord-016293-pyb00pt5	389	18	to	to	TO
cord-016293-pyb00pt5	389	19	pave	pave	VB
cord-016293-pyb00pt5	389	20	the	the	DT
cord-016293-pyb00pt5	389	21	way	way	NN
cord-016293-pyb00pt5	389	22	for	for	IN
cord-016293-pyb00pt5	389	23	new	new	JJ
cord-016293-pyb00pt5	389	24	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	389	25	and	and	CC
cord-016293-pyb00pt5	389	26	diagnostics	diagnostic	NNS
cord-016293-pyb00pt5	389	27	.	.	.
cord-016293-pyb00pt5	390	1	Fodor	Fodor	NNP
cord-016293-pyb00pt5	390	2	's	's	POS
cord-016293-pyb00pt5	390	3	former	former	JJ
cord-016293-pyb00pt5	390	4	company	company	NN
cord-016293-pyb00pt5	390	5	diversified	diversify	VBD
cord-016293-pyb00pt5	390	6	into	into	IN
cord-016293-pyb00pt5	390	7	plant	plant	NN
cord-016293-pyb00pt5	390	8	applications	application	NNS
cord-016293-pyb00pt5	390	9	by	by	IN
cord-016293-pyb00pt5	390	10	developing	develop	VBG
cord-016293-pyb00pt5	390	11	a	a	DT
cord-016293-pyb00pt5	390	12	chip	chip	NN
cord-016293-pyb00pt5	390	13	of	of	IN
cord-016293-pyb00pt5	390	14	the	the	DT
cord-016293-pyb00pt5	390	15	archetypal	archetypal	JJ
cord-016293-pyb00pt5	390	16	model	model	NN
cord-016293-pyb00pt5	390	17	of	of	IN
cord-016293-pyb00pt5	390	18	plant	plant	NN
cord-016293-pyb00pt5	390	19	systems	system	NNS
cord-016293-pyb00pt5	390	20	Arabidopsis	Arabidopsis	NNP
cord-016293-pyb00pt5	390	21	and	and	CC
cord-016293-pyb00pt5	390	22	supplied	supply	VBD
cord-016293-pyb00pt5	390	23	Pioneer	Pioneer	NNP
cord-016293-pyb00pt5	390	24	Hi	Hi	NNP
cord-016293-pyb00pt5	390	25	Bred	breed	VBD
cord-016293-pyb00pt5	390	26	with	with	IN
cord-016293-pyb00pt5	390	27	custom	custom	NN
cord-016293-pyb00pt5	390	28	DNA	dna	NN
cord-016293-pyb00pt5	390	29	chips	chip	NNS
cord-016293-pyb00pt5	390	30	for	for	IN
cord-016293-pyb00pt5	390	31	monitoring	monitor	VBG
cord-016293-pyb00pt5	390	32	maize	maize	NN
cord-016293-pyb00pt5	390	33	gene	gene	NN
cord-016293-pyb00pt5	390	34	expression	expression	NN
cord-016293-pyb00pt5	390	35	.	.	.
cord-016293-pyb00pt5	391	1	They	-PRON-	PRP
cord-016293-pyb00pt5	391	2	(	(	-LRB-
cord-016293-pyb00pt5	391	3	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	391	4	)	)	-RRB-
cord-016293-pyb00pt5	391	5	have	have	VBP
cord-016293-pyb00pt5	391	6	established	establish	VBN
cord-016293-pyb00pt5	391	7	programs	program	NNS
cord-016293-pyb00pt5	391	8	where	where	WRB
cord-016293-pyb00pt5	391	9	academic	academic	JJ
cord-016293-pyb00pt5	391	10	scientists	scientist	NNS
cord-016293-pyb00pt5	391	11	can	can	MD
cord-016293-pyb00pt5	391	12	use	use	VB
cord-016293-pyb00pt5	391	13	company	company	NN
cord-016293-pyb00pt5	391	14	facilities	facility	NNS
cord-016293-pyb00pt5	391	15	at	at	IN
cord-016293-pyb00pt5	391	16	a	a	DT
cord-016293-pyb00pt5	391	17	reduced	reduce	VBN
cord-016293-pyb00pt5	391	18	price	price	NN
cord-016293-pyb00pt5	391	19	and	and	CC
cord-016293-pyb00pt5	391	20	set	set	VB
cord-016293-pyb00pt5	391	21	up	up	RP
cord-016293-pyb00pt5	391	22	'	'	''
cord-016293-pyb00pt5	391	23	user	user	NN
cord-016293-pyb00pt5	391	24	centers	center	NNS
cord-016293-pyb00pt5	391	25	'	'	''
cord-016293-pyb00pt5	391	26	at	at	IN
cord-016293-pyb00pt5	391	27	selected	select	VBN
cord-016293-pyb00pt5	391	28	universities	university	NNS
cord-016293-pyb00pt5	391	29	.	.	.
cord-016293-pyb00pt5	392	1	A	a	DT
cord-016293-pyb00pt5	392	2	related	related	JJ
cord-016293-pyb00pt5	392	3	but	but	CC
cord-016293-pyb00pt5	392	4	less	less	RBR
cord-016293-pyb00pt5	392	5	complex	complex	JJ
cord-016293-pyb00pt5	392	6	technology	technology	NN
cord-016293-pyb00pt5	392	7	called	call	VBN
cord-016293-pyb00pt5	392	8	'	'	``
cord-016293-pyb00pt5	392	9	spotted	spot	VBD
cord-016293-pyb00pt5	392	10	'	'	''
cord-016293-pyb00pt5	392	11	DNA	dna	NN
cord-016293-pyb00pt5	392	12	chips	chip	NNS
cord-016293-pyb00pt5	392	13	involves	involve	VBZ
cord-016293-pyb00pt5	392	14	precisely	precisely	RB
cord-016293-pyb00pt5	392	15	spotting	spot	VBG
cord-016293-pyb00pt5	392	16	very	very	RB
cord-016293-pyb00pt5	392	17	small	small	JJ
cord-016293-pyb00pt5	392	18	droplets	droplet	NNS
cord-016293-pyb00pt5	392	19	of	of	IN
cord-016293-pyb00pt5	392	20	genomic	genomic	JJ
cord-016293-pyb00pt5	392	21	or	or	CC
cord-016293-pyb00pt5	392	22	cDNA	cdna	NN
cord-016293-pyb00pt5	392	23	clones	clone	NNS
cord-016293-pyb00pt5	392	24	or	or	CC
cord-016293-pyb00pt5	392	25	PCR	PCR	NNP
cord-016293-pyb00pt5	392	26	samples	sample	NNS
cord-016293-pyb00pt5	392	27	on	on	IN
cord-016293-pyb00pt5	392	28	a	a	DT
cord-016293-pyb00pt5	392	29	microscope	microscope	NN
cord-016293-pyb00pt5	392	30	slide	slide	NN
cord-016293-pyb00pt5	392	31	.	.	.
cord-016293-pyb00pt5	393	1	The	the	DT
cord-016293-pyb00pt5	393	2	process	process	NN
cord-016293-pyb00pt5	393	3	uses	use	VBZ
cord-016293-pyb00pt5	393	4	a	a	DT
cord-016293-pyb00pt5	393	5	robotic	robotic	JJ
cord-016293-pyb00pt5	393	6	device	device	NN
cord-016293-pyb00pt5	393	7	with	with	IN
cord-016293-pyb00pt5	393	8	a	a	DT
cord-016293-pyb00pt5	393	9	print	print	NN
cord-016293-pyb00pt5	393	10	head	head	NN
cord-016293-pyb00pt5	393	11	bearing	bear	VBG
cord-016293-pyb00pt5	393	12	fine	fine	RB
cord-016293-pyb00pt5	393	13	"	"	``
cord-016293-pyb00pt5	393	14	repeatograph	repeatograph	JJ
cord-016293-pyb00pt5	393	15	"	"	''
cord-016293-pyb00pt5	393	16	tips	tip	NNS
cord-016293-pyb00pt5	393	17	that	that	WDT
cord-016293-pyb00pt5	393	18	work	work	VBP
cord-016293-pyb00pt5	393	19	like	like	IN
cord-016293-pyb00pt5	393	20	fountain	fountain	NN
cord-016293-pyb00pt5	393	21	pens	pen	NNS
cord-016293-pyb00pt5	393	22	to	to	TO
cord-016293-pyb00pt5	393	23	draw	draw	VB
cord-016293-pyb00pt5	393	24	up	up	RP
cord-016293-pyb00pt5	393	25	DNA	dna	NN
cord-016293-pyb00pt5	393	26	samples	sample	NNS
cord-016293-pyb00pt5	393	27	from	from	IN
cord-016293-pyb00pt5	393	28	a	a	DT
cord-016293-pyb00pt5	393	29	96-well	96-well	CD
cord-016293-pyb00pt5	393	30	plate	plate	NN
cord-016293-pyb00pt5	393	31	and	and	CC
cord-016293-pyb00pt5	393	32	spot	spot	VB
cord-016293-pyb00pt5	393	33	tiny	tiny	JJ
cord-016293-pyb00pt5	393	34	amounts	amount	NNS
cord-016293-pyb00pt5	393	35	on	on	IN
cord-016293-pyb00pt5	393	36	a	a	DT
cord-016293-pyb00pt5	393	37	slide	slide	NN
cord-016293-pyb00pt5	393	38	.	.	.
cord-016293-pyb00pt5	394	1	Up	up	IN
cord-016293-pyb00pt5	394	2	to	to	TO
cord-016293-pyb00pt5	394	3	10,000	10,000	CD
cord-016293-pyb00pt5	394	4	individual	individual	JJ
cord-016293-pyb00pt5	394	5	clones	clone	NNS
cord-016293-pyb00pt5	394	6	can	can	MD
cord-016293-pyb00pt5	394	7	be	be	VB
cord-016293-pyb00pt5	394	8	spotted	spot	VBN
cord-016293-pyb00pt5	394	9	in	in	IN
cord-016293-pyb00pt5	394	10	a	a	DT
cord-016293-pyb00pt5	394	11	dense	dense	JJ
cord-016293-pyb00pt5	394	12	array	array	NN
cord-016293-pyb00pt5	394	13	within	within	IN
cord-016293-pyb00pt5	394	14	one	one	CD
cord-016293-pyb00pt5	394	15	square	square	JJ
cord-016293-pyb00pt5	394	16	centimeter	centimeter	NN
cord-016293-pyb00pt5	394	17	on	on	IN
cord-016293-pyb00pt5	394	18	a	a	DT
cord-016293-pyb00pt5	394	19	glass	glass	NN
cord-016293-pyb00pt5	394	20	slide	slide	NN
cord-016293-pyb00pt5	394	21	.	.	.
cord-016293-pyb00pt5	395	1	After	after	IN
cord-016293-pyb00pt5	395	2	hybridization	hybridization	NN
cord-016293-pyb00pt5	395	3	with	with	IN
cord-016293-pyb00pt5	395	4	a	a	DT
cord-016293-pyb00pt5	395	5	fluorescent	fluorescent	NN
cord-016293-pyb00pt5	395	6	target	target	NN
cord-016293-pyb00pt5	395	7	mRNA	mrna	NN
cord-016293-pyb00pt5	395	8	,	,	,
cord-016293-pyb00pt5	395	9	signals	signal	NNS
cord-016293-pyb00pt5	395	10	are	be	VBP
cord-016293-pyb00pt5	395	11	detected	detect	VBN
cord-016293-pyb00pt5	395	12	by	by	IN
cord-016293-pyb00pt5	395	13	a	a	DT
cord-016293-pyb00pt5	395	14	custom	custom	NN
cord-016293-pyb00pt5	395	15	scanner	scanner	NN
cord-016293-pyb00pt5	395	16	.	.	.
cord-016293-pyb00pt5	396	1	This	this	DT
cord-016293-pyb00pt5	396	2	is	be	VBZ
cord-016293-pyb00pt5	396	3	the	the	DT
cord-016293-pyb00pt5	396	4	basis	basis	NN
cord-016293-pyb00pt5	396	5	of	of	IN
cord-016293-pyb00pt5	396	6	the	the	DT
cord-016293-pyb00pt5	396	7	systems	system	NNS
cord-016293-pyb00pt5	396	8	used	use	VBN
cord-016293-pyb00pt5	396	9	by	by	IN
cord-016293-pyb00pt5	396	10	Molecular	Molecular	NNP
cord-016293-pyb00pt5	396	11	Dynamics	Dynamics	NNP
cord-016293-pyb00pt5	396	12	and	and	CC
cord-016293-pyb00pt5	396	13	Incyte	Incyte	NNP
cord-016293-pyb00pt5	396	14	(	(	-LRB-
cord-016293-pyb00pt5	396	15	who	who	WP
cord-016293-pyb00pt5	396	16	acquired	acquire	VBD
cord-016293-pyb00pt5	396	17	this	this	DT
cord-016293-pyb00pt5	396	18	technology	technology	NN
cord-016293-pyb00pt5	396	19	when	when	WRB
cord-016293-pyb00pt5	396	20	it	-PRON-	PRP
cord-016293-pyb00pt5	396	21	took	take	VBD
cord-016293-pyb00pt5	396	22	over	over	RP
cord-016293-pyb00pt5	396	23	Synteni	Synteni	NNP
cord-016293-pyb00pt5	396	24	)	)	-RRB-
cord-016293-pyb00pt5	396	25	.	.	.
cord-016293-pyb00pt5	397	1	In	in	IN
cord-016293-pyb00pt5	397	2	1997	1997	CD
cord-016293-pyb00pt5	397	3	,	,	,
cord-016293-pyb00pt5	397	4	Incyte	Incyte	NNP
cord-016293-pyb00pt5	397	5	was	be	VBD
cord-016293-pyb00pt5	397	6	looking	look	VBG
cord-016293-pyb00pt5	397	7	to	to	TO
cord-016293-pyb00pt5	397	8	gather	gather	VB
cord-016293-pyb00pt5	397	9	more	more	JJR
cord-016293-pyb00pt5	397	10	data	datum	NNS
cord-016293-pyb00pt5	397	11	for	for	IN
cord-016293-pyb00pt5	397	12	its	-PRON-	PRP$
cord-016293-pyb00pt5	397	13	library	library	NN
cord-016293-pyb00pt5	397	14	and	and	CC
cord-016293-pyb00pt5	397	15	perform	perform	VB
cord-016293-pyb00pt5	397	16	experiments	experiment	NNS
cord-016293-pyb00pt5	397	17	for	for	IN
cord-016293-pyb00pt5	397	18	corporate	corporate	JJ
cord-016293-pyb00pt5	397	19	subscribers	subscriber	NNS
cord-016293-pyb00pt5	397	20	.	.	.
cord-016293-pyb00pt5	398	1	The	the	DT
cord-016293-pyb00pt5	398	2	company	company	NN
cord-016293-pyb00pt5	398	3	considered	consider	VBD
cord-016293-pyb00pt5	398	4	buying	buy	VBG
cord-016293-pyb00pt5	398	5	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	398	6	GeneChips	GeneChips	NNP
cord-016293-pyb00pt5	398	7	but	but	CC
cord-016293-pyb00pt5	398	8	opted	opt	VBD
cord-016293-pyb00pt5	398	9	instead	instead	RB
cord-016293-pyb00pt5	398	10	to	to	TO
cord-016293-pyb00pt5	398	11	purchase	purchase	VB
cord-016293-pyb00pt5	398	12	the	the	DT
cord-016293-pyb00pt5	398	13	smaller	small	JJR
cord-016293-pyb00pt5	398	14	Synteni	Synteni	NNP
cord-016293-pyb00pt5	398	15	,	,	,
cord-016293-pyb00pt5	398	16	which	which	WDT
cord-016293-pyb00pt5	398	17	had	have	VBD
cord-016293-pyb00pt5	398	18	sprung	spring	VBN
cord-016293-pyb00pt5	398	19	out	out	IN
cord-016293-pyb00pt5	398	20	of	of	IN
cord-016293-pyb00pt5	398	21	Pat	Pat	NNP
cord-016293-pyb00pt5	398	22	Brown	Brown	NNP
cord-016293-pyb00pt5	398	23	's	's	POS
cord-016293-pyb00pt5	398	24	Stanford	Stanford	NNP
cord-016293-pyb00pt5	398	25	array	array	NN
cord-016293-pyb00pt5	398	26	effort	effort	NN
cord-016293-pyb00pt5	398	27	.	.	.
cord-016293-pyb00pt5	399	1	Synteni	Synteni	NNP
cord-016293-pyb00pt5	399	2	's	's	POS
cord-016293-pyb00pt5	399	3	contact	contact	NN
cord-016293-pyb00pt5	399	4	printing	printing	NN
cord-016293-pyb00pt5	399	5	technology	technology	NN
cord-016293-pyb00pt5	399	6	resulted	result	VBD
cord-016293-pyb00pt5	399	7	in	in	IN
cord-016293-pyb00pt5	399	8	dense	dense	JJ
cord-016293-pyb00pt5	399	9	-and	-and	CC
cord-016293-pyb00pt5	399	10	cheaper	cheap	JJR
cord-016293-pyb00pt5	399	11	-arrays	-array	NNS
cord-016293-pyb00pt5	399	12	.	.	.
cord-016293-pyb00pt5	400	1	Though	Though	NNP
cord-016293-pyb00pt5	400	2	Incyte	Incyte	NNP
cord-016293-pyb00pt5	400	3	used	use	VBD
cord-016293-pyb00pt5	400	4	the	the	DT
cord-016293-pyb00pt5	400	5	chips	chip	NNS
cord-016293-pyb00pt5	400	6	only	only	RB
cord-016293-pyb00pt5	400	7	internally	internally	RB
cord-016293-pyb00pt5	400	8	,	,	,
cord-016293-pyb00pt5	400	9	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	400	10	sued	sue	VBD
cord-016293-pyb00pt5	400	11	,	,	,
cord-016293-pyb00pt5	400	12	claiming	claim	VBG
cord-016293-pyb00pt5	400	13	Synteni	Synteni	NNP
cord-016293-pyb00pt5	400	14	/	/	SYM
cord-016293-pyb00pt5	400	15	Incyte	Incyte	NNP
cord-016293-pyb00pt5	400	16	was	be	VBD
cord-016293-pyb00pt5	400	17	infringing	infringe	VBG
cord-016293-pyb00pt5	400	18	on	on	IN
cord-016293-pyb00pt5	400	19	its	-PRON-	PRP$
cord-016293-pyb00pt5	400	20	chip	chip	NN
cord-016293-pyb00pt5	400	21	density	density	NN
cord-016293-pyb00pt5	400	22	patents	patent	NNS
cord-016293-pyb00pt5	400	23	.	.	.
cord-016293-pyb00pt5	401	1	The	the	DT
cord-016293-pyb00pt5	401	2	suit	suit	NN
cord-016293-pyb00pt5	401	3	argued	argue	VBD
cord-016293-pyb00pt5	401	4	that	that	IN
cord-016293-pyb00pt5	401	5	dense	dense	JJ
cord-016293-pyb00pt5	401	6	biochips	biochip	NNS
cord-016293-pyb00pt5	401	7	-regardless	-regardless	NN
cord-016293-pyb00pt5	401	8	of	of	IN
cord-016293-pyb00pt5	401	9	whether	whether	IN
cord-016293-pyb00pt5	401	10	they	-PRON-	PRP
cord-016293-pyb00pt5	401	11	use	use	VBP
cord-016293-pyb00pt5	401	12	photolithography	photolithography	NN
cord-016293-pyb00pt5	402	1	-cannot	-cannot	:
cord-016293-pyb00pt5	402	2	be	be	VB
cord-016293-pyb00pt5	402	3	made	make	VBN
cord-016293-pyb00pt5	402	4	without	without	IN
cord-016293-pyb00pt5	402	5	a	a	DT
cord-016293-pyb00pt5	402	6	license	license	NN
cord-016293-pyb00pt5	402	7	from	from	IN
cord-016293-pyb00pt5	402	8	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	402	9	!	!	.
cord-016293-pyb00pt5	403	1	And	and	CC
cord-016293-pyb00pt5	403	2	in	in	IN
cord-016293-pyb00pt5	403	3	a	a	DT
cord-016293-pyb00pt5	403	4	litigious	litigious	JJ
cord-016293-pyb00pt5	403	5	Congo	Congo	NNP
cord-016293-pyb00pt5	403	6	line	line	NN
cord-016293-pyb00pt5	403	7	endemic	endemic	JJ
cord-016293-pyb00pt5	403	8	of	of	IN
cord-016293-pyb00pt5	403	9	this	this	DT
cord-016293-pyb00pt5	403	10	hi	hi	JJ
cord-016293-pyb00pt5	403	11	-	-	HYPH
cord-016293-pyb00pt5	403	12	tech	tech	NN
cord-016293-pyb00pt5	403	13	era	era	NN
cord-016293-pyb00pt5	403	14	Incyte	Incyte	NNP
cord-016293-pyb00pt5	403	15	countersued	countersue	VBD
cord-016293-pyb00pt5	403	16	and	and	CC
cord-016293-pyb00pt5	403	17	for	for	IN
cord-016293-pyb00pt5	403	18	good	good	JJ
cord-016293-pyb00pt5	403	19	measure	measure	NN
cord-016293-pyb00pt5	403	20	also	also	RB
cord-016293-pyb00pt5	403	21	filed	file	VBN
cord-016293-pyb00pt5	403	22	against	against	IN
cord-016293-pyb00pt5	403	23	genetic	genetic	JJ
cord-016293-pyb00pt5	403	24	database	database	NN
cord-016293-pyb00pt5	403	25	competitor	competitor	NN
cord-016293-pyb00pt5	403	26	Gene	Gene	NNP
cord-016293-pyb00pt5	403	27	Logic	Logic	NNP
cord-016293-pyb00pt5	403	28	for	for	IN
cord-016293-pyb00pt5	403	29	infringing	infringe	VBG
cord-016293-pyb00pt5	403	30	Incyte	Incyte	NNP
cord-016293-pyb00pt5	403	31	's	's	POS
cord-016293-pyb00pt5	403	32	patents	patent	NNS
cord-016293-pyb00pt5	403	33	on	on	IN
cord-016293-pyb00pt5	403	34	database	database	NN
cord-016293-pyb00pt5	403	35	building	building	NN
cord-016293-pyb00pt5	403	36	.	.	.
cord-016293-pyb00pt5	404	1	Meanwhile	meanwhile	RB
cord-016293-pyb00pt5	404	2	,	,	,
cord-016293-pyb00pt5	404	3	Hyseq	Hyseq	NNP
cord-016293-pyb00pt5	404	4	sued	sue	VBD
cord-016293-pyb00pt5	404	5	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	404	6	,	,	,
cord-016293-pyb00pt5	404	7	claiming	claim	VBG
cord-016293-pyb00pt5	404	8	infringement	infringement	NN
cord-016293-pyb00pt5	404	9	of	of	IN
cord-016293-pyb00pt5	404	10	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	404	11	hybridization	hybridization	NN
cord-016293-pyb00pt5	404	12	patents	patent	NNS
cord-016293-pyb00pt5	404	13	obtained	obtain	VBN
cord-016293-pyb00pt5	404	14	by	by	IN
cord-016293-pyb00pt5	404	15	its	-PRON-	PRP$
cord-016293-pyb00pt5	404	16	CSO	CSO	NNP
cord-016293-pyb00pt5	404	17	.	.	.
cord-016293-pyb00pt5	405	1	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	405	2	,	,	,
cord-016293-pyb00pt5	405	3	in	in	IN
cord-016293-pyb00pt5	405	4	turn	turn	NN
cord-016293-pyb00pt5	405	5	,	,	,
cord-016293-pyb00pt5	405	6	filed	file	VBD
cord-016293-pyb00pt5	405	7	a	a	DT
cord-016293-pyb00pt5	405	8	countersuit	countersuit	NN
cord-016293-pyb00pt5	405	9	,	,	,
cord-016293-pyb00pt5	405	10	claiming	claim	VBG
cord-016293-pyb00pt5	405	11	Hyseq	Hyseq	NNP
cord-016293-pyb00pt5	405	12	infringed	infringe	VBD
cord-016293-pyb00pt5	405	13	the	the	DT
cord-016293-pyb00pt5	405	14	spotted	spot	VBN
cord-016293-pyb00pt5	405	15	array	array	NN
cord-016293-pyb00pt5	405	16	patents	patent	NNS
cord-016293-pyb00pt5	405	17	.	.	.
cord-016293-pyb00pt5	406	1	Hyseq	Hyseq	NNP
cord-016293-pyb00pt5	406	2	then	then	RB
cord-016293-pyb00pt5	406	3	reached	reach	VBD
cord-016293-pyb00pt5	406	4	back	back	RB
cord-016293-pyb00pt5	406	5	and	and	CC
cord-016293-pyb00pt5	406	6	found	find	VBD
cord-016293-pyb00pt5	406	7	an	an	DT
cord-016293-pyb00pt5	406	8	additional	additional	JJ
cord-016293-pyb00pt5	406	9	hybridization	hybridization	NN
cord-016293-pyb00pt5	406	10	patent	patent	NN
cord-016293-pyb00pt5	406	11	it	-PRON-	PRP
cord-016293-pyb00pt5	406	12	claimed	claim	VBD
cord-016293-pyb00pt5	406	13	that	that	IN
cord-016293-pyb00pt5	406	14	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	406	15	had	have	VBD
cord-016293-pyb00pt5	406	16	infringed	infringe	VBN
cord-016293-pyb00pt5	406	17	.	.	.
cord-016293-pyb00pt5	407	1	And	and	CC
cord-016293-pyb00pt5	407	2	so	so	RB
cord-016293-pyb00pt5	407	3	on	on	RB
cord-016293-pyb00pt5	407	4	into	into	IN
cord-016293-pyb00pt5	407	5	the	the	DT
cord-016293-pyb00pt5	407	6	next	next	JJ
cord-016293-pyb00pt5	407	7	millennium	millennium	NN
cord-016293-pyb00pt5	407	8	!	!	.
cord-016293-pyb00pt5	408	1	In	in	IN
cord-016293-pyb00pt5	408	2	part	part	NN
cord-016293-pyb00pt5	408	3	to	to	TO
cord-016293-pyb00pt5	408	4	avoid	avoid	VB
cord-016293-pyb00pt5	408	5	all	all	DT
cord-016293-pyb00pt5	408	6	of	of	IN
cord-016293-pyb00pt5	408	7	this	this	DT
cord-016293-pyb00pt5	408	8	another	another	DT
cord-016293-pyb00pt5	408	9	California	California	NNP
cord-016293-pyb00pt5	408	10	company	company	NN
cord-016293-pyb00pt5	408	11	Nanogen	Nanogen	NNP
cord-016293-pyb00pt5	408	12	,	,	,
cord-016293-pyb00pt5	408	13	Inc.	Inc.	NNP
cord-016293-pyb00pt5	408	14	took	take	VBD
cord-016293-pyb00pt5	408	15	a	a	DT
cord-016293-pyb00pt5	408	16	different	different	JJ
cord-016293-pyb00pt5	408	17	approach	approach	NN
cord-016293-pyb00pt5	408	18	to	to	IN
cord-016293-pyb00pt5	408	19	single	single	JJ
cord-016293-pyb00pt5	408	20	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	408	21	polymorphism	polymorphism	NN
cord-016293-pyb00pt5	408	22	discrimination	discrimination	NN
cord-016293-pyb00pt5	408	23	technology	technology	NN
cord-016293-pyb00pt5	408	24	.	.	.
cord-016293-pyb00pt5	409	1	In	in	IN
cord-016293-pyb00pt5	409	2	an	an	DT
cord-016293-pyb00pt5	409	3	article	article	NN
cord-016293-pyb00pt5	409	4	in	in	IN
cord-016293-pyb00pt5	409	5	the	the	DT
cord-016293-pyb00pt5	409	6	April	April	NNP
cord-016293-pyb00pt5	409	7	2000	2000	CD
cord-016293-pyb00pt5	409	8	edition	edition	NN
cord-016293-pyb00pt5	409	9	of	of	IN
cord-016293-pyb00pt5	409	10	Nature	Nature	NNP
cord-016293-pyb00pt5	409	11	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	409	12	,	,	,
cord-016293-pyb00pt5	409	13	entitled	entitle	VBN
cord-016293-pyb00pt5	409	14	"	"	``
cord-016293-pyb00pt5	409	15	Single	single	JJ
cord-016293-pyb00pt5	409	16	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	409	17	polymorphic	polymorphic	JJ
cord-016293-pyb00pt5	409	18	discrimination	discrimination	NN
cord-016293-pyb00pt5	409	19	by	by	IN
cord-016293-pyb00pt5	409	20	an	an	DT
cord-016293-pyb00pt5	409	21	electronic	electronic	JJ
cord-016293-pyb00pt5	409	22	dot	dot	NN
cord-016293-pyb00pt5	409	23	blot	blot	NN
cord-016293-pyb00pt5	409	24	assay	assay	NN
cord-016293-pyb00pt5	409	25	on	on	IN
cord-016293-pyb00pt5	409	26	semiconductor	semiconductor	NN
cord-016293-pyb00pt5	409	27	microchips	microchip	NNS
cord-016293-pyb00pt5	409	28	,	,	,
cord-016293-pyb00pt5	409	29	"	"	''
cord-016293-pyb00pt5	409	30	Nanogen	Nanogen	NNP
cord-016293-pyb00pt5	409	31	describes	describe	VBZ
cord-016293-pyb00pt5	409	32	the	the	DT
cord-016293-pyb00pt5	409	33	use	use	NN
cord-016293-pyb00pt5	409	34	of	of	IN
cord-016293-pyb00pt5	409	35	microchips	microchip	NNS
cord-016293-pyb00pt5	409	36	to	to	TO
cord-016293-pyb00pt5	409	37	identify	identify	VB
cord-016293-pyb00pt5	409	38	variants	variant	NNS
cord-016293-pyb00pt5	409	39	of	of	IN
cord-016293-pyb00pt5	409	40	the	the	DT
cord-016293-pyb00pt5	409	41	mannose	mannose	NN
cord-016293-pyb00pt5	409	42	binding	bind	VBG
cord-016293-pyb00pt5	409	43	protein	protein	NN
cord-016293-pyb00pt5	409	44	gene	gene	NN
cord-016293-pyb00pt5	409	45	that	that	WDT
cord-016293-pyb00pt5	409	46	differ	differ	VBP
cord-016293-pyb00pt5	409	47	from	from	IN
cord-016293-pyb00pt5	409	48	one	one	CD
cord-016293-pyb00pt5	409	49	another	another	DT
cord-016293-pyb00pt5	409	50	by	by	IN
cord-016293-pyb00pt5	409	51	only	only	RB
cord-016293-pyb00pt5	409	52	a	a	DT
cord-016293-pyb00pt5	409	53	single	single	JJ
cord-016293-pyb00pt5	409	54	DNA	dna	NN
cord-016293-pyb00pt5	409	55	base	base	NN
cord-016293-pyb00pt5	409	56	.	.	.
cord-016293-pyb00pt5	410	1	The	the	DT
cord-016293-pyb00pt5	410	2	mannose	mannose	NN
cord-016293-pyb00pt5	410	3	binding	bind	VBG
cord-016293-pyb00pt5	410	4	protein	protein	NN
cord-016293-pyb00pt5	410	5	(	(	-LRB-
cord-016293-pyb00pt5	410	6	MBP	MBP	NNP
cord-016293-pyb00pt5	410	7	)	)	-RRB-
cord-016293-pyb00pt5	410	8	is	be	VBZ
cord-016293-pyb00pt5	410	9	a	a	DT
cord-016293-pyb00pt5	410	10	key	key	JJ
cord-016293-pyb00pt5	410	11	component	component	NN
cord-016293-pyb00pt5	410	12	of	of	IN
cord-016293-pyb00pt5	410	13	the	the	DT
cord-016293-pyb00pt5	410	14	innate	innate	JJ
cord-016293-pyb00pt5	410	15	immune	immune	JJ
cord-016293-pyb00pt5	410	16	system	system	NN
cord-016293-pyb00pt5	410	17	in	in	IN
cord-016293-pyb00pt5	410	18	children	child	NNS
cord-016293-pyb00pt5	410	19	who	who	WP
cord-016293-pyb00pt5	410	20	have	have	VBP
cord-016293-pyb00pt5	410	21	not	not	RB
cord-016293-pyb00pt5	410	22	yet	yet	RB
cord-016293-pyb00pt5	410	23	developed	develop	VBN
cord-016293-pyb00pt5	410	24	immunity	immunity	NN
cord-016293-pyb00pt5	410	25	to	to	IN
cord-016293-pyb00pt5	410	26	a	a	DT
cord-016293-pyb00pt5	410	27	variety	variety	NN
cord-016293-pyb00pt5	410	28	of	of	IN
cord-016293-pyb00pt5	410	29	pathogens	pathogen	NNS
cord-016293-pyb00pt5	410	30	.	.	.
cord-016293-pyb00pt5	411	1	To	to	IN
cord-016293-pyb00pt5	411	2	date	date	NN
cord-016293-pyb00pt5	411	3	,	,	,
cord-016293-pyb00pt5	411	4	four	four	CD
cord-016293-pyb00pt5	411	5	distinct	distinct	JJ
cord-016293-pyb00pt5	411	6	variants	variant	NNS
cord-016293-pyb00pt5	411	7	(	(	-LRB-
cord-016293-pyb00pt5	411	8	alleles	allele	NNS
cord-016293-pyb00pt5	411	9	)	)	-RRB-
cord-016293-pyb00pt5	411	10	of	of	IN
cord-016293-pyb00pt5	411	11	this	this	DT
cord-016293-pyb00pt5	411	12	gene	gene	NN
cord-016293-pyb00pt5	411	13	have	have	VBP
cord-016293-pyb00pt5	411	14	been	be	VBN
cord-016293-pyb00pt5	411	15	identified	identify	VBN
cord-016293-pyb00pt5	411	16	,	,	,
cord-016293-pyb00pt5	411	17	all	all	DT
cord-016293-pyb00pt5	411	18	differing	differ	VBG
cord-016293-pyb00pt5	411	19	by	by	IN
cord-016293-pyb00pt5	411	20	only	only	RB
cord-016293-pyb00pt5	411	21	a	a	DT
cord-016293-pyb00pt5	411	22	single	single	JJ
cord-016293-pyb00pt5	411	23	nucleotide	nucleotide	NN
cord-016293-pyb00pt5	411	24	of	of	IN
cord-016293-pyb00pt5	411	25	DNA	dna	NN
cord-016293-pyb00pt5	411	26	.	.	.
cord-016293-pyb00pt5	412	1	MBP	MBP	NNP
cord-016293-pyb00pt5	412	2	was	be	VBD
cord-016293-pyb00pt5	412	3	selected	select	VBN
cord-016293-pyb00pt5	412	4	for	for	IN
cord-016293-pyb00pt5	412	5	this	this	DT
cord-016293-pyb00pt5	412	6	study	study	NN
cord-016293-pyb00pt5	412	7	because	because	IN
cord-016293-pyb00pt5	412	8	of	of	IN
cord-016293-pyb00pt5	412	9	its	-PRON-	PRP$
cord-016293-pyb00pt5	412	10	potential	potential	JJ
cord-016293-pyb00pt5	412	11	clinical	clinical	JJ
cord-016293-pyb00pt5	412	12	relevance	relevance	NN
cord-016293-pyb00pt5	412	13	and	and	CC
cord-016293-pyb00pt5	412	14	its	-PRON-	PRP$
cord-016293-pyb00pt5	412	15	genetic	genetic	JJ
cord-016293-pyb00pt5	412	16	complexity	complexity	NN
cord-016293-pyb00pt5	412	17	.	.	.
cord-016293-pyb00pt5	413	1	The	the	DT
cord-016293-pyb00pt5	413	2	samples	sample	NNS
cord-016293-pyb00pt5	413	3	were	be	VBD
cord-016293-pyb00pt5	413	4	assembled	assemble	VBN
cord-016293-pyb00pt5	413	5	at	at	IN
cord-016293-pyb00pt5	413	6	the	the	DT
cord-016293-pyb00pt5	413	7	NCI	NCI	NNP
cord-016293-pyb00pt5	413	8	laboratory	laboratory	NN
cord-016293-pyb00pt5	413	9	in	in	IN
cord-016293-pyb00pt5	413	10	conjunction	conjunction	NN
cord-016293-pyb00pt5	413	11	with	with	IN
cord-016293-pyb00pt5	413	12	the	the	DT
cord-016293-pyb00pt5	413	13	National	National	NNP
cord-016293-pyb00pt5	413	14	Institutes	Institutes	NNPS
cord-016293-pyb00pt5	413	15	of	of	IN
cord-016293-pyb00pt5	413	16	Health	Health	NNP
cord-016293-pyb00pt5	413	17	and	and	CC
cord-016293-pyb00pt5	413	18	transferred	transfer	VBN
cord-016293-pyb00pt5	413	19	to	to	IN
cord-016293-pyb00pt5	413	20	Nanogen	Nanogen	NNP
cord-016293-pyb00pt5	413	21	for	for	IN
cord-016293-pyb00pt5	413	22	analysis	analysis	NN
cord-016293-pyb00pt5	413	23	.	.	.
cord-016293-pyb00pt5	414	1	However	however	RB
cord-016293-pyb00pt5	414	2	,	,	,
cord-016293-pyb00pt5	414	3	from	from	IN
cord-016293-pyb00pt5	414	4	a	a	DT
cord-016293-pyb00pt5	414	5	high	high	JJ
cord-016293-pyb00pt5	414	6	throughput	throughput	NN
cord-016293-pyb00pt5	414	7	perspective	perspective	NN
cord-016293-pyb00pt5	414	8	there	there	EX
cord-016293-pyb00pt5	414	9	is	be	VBZ
cord-016293-pyb00pt5	414	10	a	a	DT
cord-016293-pyb00pt5	414	11	question	question	NN
cord-016293-pyb00pt5	414	12	mark	mark	NN
cord-016293-pyb00pt5	414	13	over	over	IN
cord-016293-pyb00pt5	414	14	microarrays	microarray	NNS
cord-016293-pyb00pt5	414	15	.	.	.
cord-016293-pyb00pt5	415	1	Mark	Mark	NNP
cord-016293-pyb00pt5	415	2	Benjamin	Benjamin	NNP
cord-016293-pyb00pt5	415	3	,	,	,
cord-016293-pyb00pt5	415	4	senior	senior	JJ
cord-016293-pyb00pt5	415	5	director	director	NN
cord-016293-pyb00pt5	415	6	of	of	IN
cord-016293-pyb00pt5	415	7	business	business	NN
cord-016293-pyb00pt5	415	8	development	development	NN
cord-016293-pyb00pt5	415	9	at	at	IN
cord-016293-pyb00pt5	415	10	Rosetta	Rosetta	NNP
cord-016293-pyb00pt5	415	11	Inpharmatics	Inpharmatics	NNP
cord-016293-pyb00pt5	415	12	(	(	-LRB-
cord-016293-pyb00pt5	415	13	Kirkland	Kirkland	NNP
cord-016293-pyb00pt5	415	14	,	,	,
cord-016293-pyb00pt5	415	15	WA	WA	NNP
cord-016293-pyb00pt5	415	16	)	)	-RRB-
cord-016293-pyb00pt5	415	17	,	,	,
cord-016293-pyb00pt5	415	18	is	be	VBZ
cord-016293-pyb00pt5	415	19	skeptical	skeptical	JJ
cord-016293-pyb00pt5	415	20	about	about	IN
cord-016293-pyb00pt5	415	21	the	the	DT
cord-016293-pyb00pt5	415	22	long	long	JJ
cord-016293-pyb00pt5	415	23	-	-	HYPH
cord-016293-pyb00pt5	415	24	term	term	NN
cord-016293-pyb00pt5	415	25	prospects	prospect	NNS
cord-016293-pyb00pt5	415	26	for	for	IN
cord-016293-pyb00pt5	415	27	standard	standard	JJ
cord-016293-pyb00pt5	415	28	DNA	dna	NN
cord-016293-pyb00pt5	415	29	arrays	array	NNS
cord-016293-pyb00pt5	415	30	in	in	IN
cord-016293-pyb00pt5	415	31	high	high	JJ
cord-016293-pyb00pt5	415	32	-	-	HYPH
cord-016293-pyb00pt5	415	33	throughput	throughput	NN
cord-016293-pyb00pt5	415	34	screening	screening	NN
cord-016293-pyb00pt5	415	35	as	as	IN
cord-016293-pyb00pt5	415	36	the	the	DT
cord-016293-pyb00pt5	415	37	first	first	JJ
cord-016293-pyb00pt5	415	38	steps	step	NNS
cord-016293-pyb00pt5	415	39	require	require	VBP
cord-016293-pyb00pt5	415	40	exposing	expose	VBG
cord-016293-pyb00pt5	415	41	cells	cell	NNS
cord-016293-pyb00pt5	415	42	and	and	CC
cord-016293-pyb00pt5	415	43	then	then	RB
cord-016293-pyb00pt5	415	44	isolating	isolate	VBG
cord-016293-pyb00pt5	415	45	RNA	RNA	NNP
cord-016293-pyb00pt5	415	46	,	,	,
cord-016293-pyb00pt5	415	47	which	which	WDT
cord-016293-pyb00pt5	415	48	is	be	VBZ
cord-016293-pyb00pt5	415	49	something	something	NN
cord-016293-pyb00pt5	415	50	that	that	WDT
cord-016293-pyb00pt5	415	51	is	be	VBZ
cord-016293-pyb00pt5	415	52	very	very	RB
cord-016293-pyb00pt5	415	53	hard	hard	JJ
cord-016293-pyb00pt5	415	54	to	to	TO
cord-016293-pyb00pt5	415	55	do	do	VB
cord-016293-pyb00pt5	415	56	in	in	IN
cord-016293-pyb00pt5	415	57	a	a	DT
cord-016293-pyb00pt5	415	58	high	high	JJ
cord-016293-pyb00pt5	415	59	-	-	HYPH
cord-016293-pyb00pt5	415	60	throughput	throughput	NN
cord-016293-pyb00pt5	415	61	format	format	NN
cord-016293-pyb00pt5	415	62	.	.	.
cord-016293-pyb00pt5	416	1	Another	another	DT
cord-016293-pyb00pt5	416	2	drawback	drawback	NN
cord-016293-pyb00pt5	416	3	is	be	VBZ
cord-016293-pyb00pt5	416	4	that	that	IN
cord-016293-pyb00pt5	416	5	most	most	JJS
cord-016293-pyb00pt5	416	6	of	of	IN
cord-016293-pyb00pt5	416	7	the	the	DT
cord-016293-pyb00pt5	416	8	useful	useful	JJ
cord-016293-pyb00pt5	416	9	targets	target	NNS
cord-016293-pyb00pt5	416	10	are	be	VBP
cord-016293-pyb00pt5	416	11	likely	likely	JJ
cord-016293-pyb00pt5	416	12	to	to	TO
cord-016293-pyb00pt5	416	13	be	be	VB
cord-016293-pyb00pt5	416	14	unknown	unknown	JJ
cord-016293-pyb00pt5	416	15	(	(	-LRB-
cord-016293-pyb00pt5	416	16	particularly	particularly	RB
cord-016293-pyb00pt5	416	17	in	in	IN
cord-016293-pyb00pt5	416	18	the	the	DT
cord-016293-pyb00pt5	416	19	agricultural	agricultural	JJ
cord-016293-pyb00pt5	416	20	sciences	science	NNS
cord-016293-pyb00pt5	416	21	where	where	WRB
cord-016293-pyb00pt5	416	22	genome	genome	NN
cord-016293-pyb00pt5	416	23	sequencing	sequencing	NN
cord-016293-pyb00pt5	416	24	is	be	VBZ
cord-016293-pyb00pt5	416	25	still	still	RB
cord-016293-pyb00pt5	416	26	in	in	IN
cord-016293-pyb00pt5	416	27	its	-PRON-	PRP$
cord-016293-pyb00pt5	416	28	infancy	infancy	NN
cord-016293-pyb00pt5	416	29	)	)	-RRB-
cord-016293-pyb00pt5	416	30	,	,	,
cord-016293-pyb00pt5	416	31	and	and	CC
cord-016293-pyb00pt5	416	32	DNA	dna	NN
cord-016293-pyb00pt5	416	33	arrays	array	NNS
cord-016293-pyb00pt5	416	34	that	that	WDT
cord-016293-pyb00pt5	416	35	are	be	VBP
cord-016293-pyb00pt5	416	36	currently	currently	RB
cord-016293-pyb00pt5	416	37	available	available	JJ
cord-016293-pyb00pt5	416	38	test	test	NN
cord-016293-pyb00pt5	416	39	only	only	RB
cord-016293-pyb00pt5	416	40	for	for	IN
cord-016293-pyb00pt5	416	41	previously	previously	RB
cord-016293-pyb00pt5	416	42	sequenced	sequence	VBN
cord-016293-pyb00pt5	416	43	genes	gene	NNS
cord-016293-pyb00pt5	416	44	.	.	.
cord-016293-pyb00pt5	417	1	Indeed	indeed	RB
cord-016293-pyb00pt5	417	2	,	,	,
cord-016293-pyb00pt5	417	3	some	some	DT
cord-016293-pyb00pt5	417	4	argue	argue	VBP
cord-016293-pyb00pt5	417	5	that	that	IN
cord-016293-pyb00pt5	417	6	current	current	JJ
cord-016293-pyb00pt5	417	7	DNA	dna	NN
cord-016293-pyb00pt5	417	8	arrays	array	NNS
cord-016293-pyb00pt5	417	9	may	may	MD
cord-016293-pyb00pt5	417	10	not	not	RB
cord-016293-pyb00pt5	417	11	be	be	VB
cord-016293-pyb00pt5	417	12	sufficiently	sufficiently	RB
cord-016293-pyb00pt5	417	13	sensitive	sensitive	JJ
cord-016293-pyb00pt5	417	14	to	to	TO
cord-016293-pyb00pt5	417	15	detect	detect	VB
cord-016293-pyb00pt5	417	16	the	the	DT
cord-016293-pyb00pt5	417	17	low	low	JJ
cord-016293-pyb00pt5	417	18	expression	expression	NN
cord-016293-pyb00pt5	417	19	levels	level	NNS
cord-016293-pyb00pt5	417	20	of	of	IN
cord-016293-pyb00pt5	417	21	genes	gene	NNS
cord-016293-pyb00pt5	417	22	encoding	encode	VBG
cord-016293-pyb00pt5	417	23	targets	target	NNS
cord-016293-pyb00pt5	417	24	of	of	IN
cord-016293-pyb00pt5	417	25	particular	particular	JJ
cord-016293-pyb00pt5	417	26	interest	interest	NN
cord-016293-pyb00pt5	417	27	.	.	.
cord-016293-pyb00pt5	418	1	And	and	CC
cord-016293-pyb00pt5	418	2	the	the	DT
cord-016293-pyb00pt5	418	3	added	add	VBN
cord-016293-pyb00pt5	418	4	complication	complication	NN
cord-016293-pyb00pt5	418	5	of	of	IN
cord-016293-pyb00pt5	418	6	the	the	DT
cord-016293-pyb00pt5	418	7	companies	company	NNS
cord-016293-pyb00pt5	418	8	'	'	POS
cord-016293-pyb00pt5	418	9	reluctance	reluctance	NN
cord-016293-pyb00pt5	418	10	to	to	TO
cord-016293-pyb00pt5	418	11	provide	provide	VB
cord-016293-pyb00pt5	418	12	"	"	``
cord-016293-pyb00pt5	418	13	raw	raw	JJ
cord-016293-pyb00pt5	418	14	data	datum	NNS
cord-016293-pyb00pt5	418	15	"	"	''
cord-016293-pyb00pt5	418	16	means	mean	VBZ
cord-016293-pyb00pt5	418	17	that	that	IN
cord-016293-pyb00pt5	418	18	derived	derive	VBN
cord-016293-pyb00pt5	418	19	data	data	NN
cord-016293-pyb00pt5	418	20	sets	set	NNS
cord-016293-pyb00pt5	418	21	may	may	MD
cord-016293-pyb00pt5	418	22	be	be	VB
cord-016293-pyb00pt5	418	23	created	create	VBN
cord-016293-pyb00pt5	418	24	with	with	IN
cord-016293-pyb00pt5	418	25	less	less	JJR
cord-016293-pyb00pt5	418	26	than	than	IN
cord-016293-pyb00pt5	418	27	optimum	optimum	JJ
cord-016293-pyb00pt5	418	28	algorithims	algorithim	NNS
cord-016293-pyb00pt5	418	29	thereby	thereby	RB
cord-016293-pyb00pt5	418	30	irretrievably	irretrievably	RB
cord-016293-pyb00pt5	418	31	losing	lose	VBG
cord-016293-pyb00pt5	418	32	potentially	potentially	RB
cord-016293-pyb00pt5	418	33	valuable	valuable	JJ
cord-016293-pyb00pt5	418	34	information	information	NN
cord-016293-pyb00pt5	418	35	from	from	IN
cord-016293-pyb00pt5	418	36	the	the	DT
cord-016293-pyb00pt5	418	37	starting	starting	NN
cord-016293-pyb00pt5	418	38	material	material	NN
cord-016293-pyb00pt5	418	39	.	.	.
cord-016293-pyb00pt5	419	1	Reverse	reverse	JJ
cord-016293-pyb00pt5	419	2	engineering	engineering	NN
cord-016293-pyb00pt5	419	3	is	be	VBZ
cord-016293-pyb00pt5	419	4	a	a	DT
cord-016293-pyb00pt5	419	5	possible	possible	JJ
cord-016293-pyb00pt5	419	6	approach	approach	NN
cord-016293-pyb00pt5	419	7	but	but	CC
cord-016293-pyb00pt5	419	8	this	this	DT
cord-016293-pyb00pt5	419	9	is	be	VBZ
cord-016293-pyb00pt5	419	10	laborious	laborious	JJ
cord-016293-pyb00pt5	419	11	and	and	CC
cord-016293-pyb00pt5	419	12	time	time	NN
cord-016293-pyb00pt5	419	13	consuming	consume	VBG
cord-016293-pyb00pt5	419	14	and	and	CC
cord-016293-pyb00pt5	419	15	being	be	VBG
cord-016293-pyb00pt5	419	16	prohibited	prohibit	VBN
cord-016293-pyb00pt5	419	17	by	by	IN
cord-016293-pyb00pt5	419	18	many	many	JJ
cord-016293-pyb00pt5	419	19	contracts	contract	NNS
cord-016293-pyb00pt5	419	20	may	may	MD
cord-016293-pyb00pt5	419	21	arouse	arouse	VB
cord-016293-pyb00pt5	419	22	the	the	DT
cord-016293-pyb00pt5	419	23	interest	interest	NN
cord-016293-pyb00pt5	419	24	of	of	IN
cord-016293-pyb00pt5	419	25	the	the	DT
cord-016293-pyb00pt5	419	26	ever	ever	RB
cord-016293-pyb00pt5	419	27	-	-	HYPH
cord-016293-pyb00pt5	419	28	vigilant	vigilant	JJ
cord-016293-pyb00pt5	419	29	corporate	corporate	JJ
cord-016293-pyb00pt5	419	30	lawyers	lawyer	NNS
cord-016293-pyb00pt5	419	31	.	.	.
cord-016293-pyb00pt5	420	1	Over	over	IN
cord-016293-pyb00pt5	420	2	the	the	DT
cord-016293-pyb00pt5	420	3	course	course	NN
cord-016293-pyb00pt5	420	4	of	of	IN
cord-016293-pyb00pt5	420	5	the	the	DT
cord-016293-pyb00pt5	420	6	nineties	ninety	NNS
cord-016293-pyb00pt5	420	7	,	,	,
cord-016293-pyb00pt5	420	8	outgrowths	outgrowth	NNS
cord-016293-pyb00pt5	420	9	of	of	IN
cord-016293-pyb00pt5	420	10	functional	functional	JJ
cord-016293-pyb00pt5	420	11	genomics	genomic	NNS
cord-016293-pyb00pt5	420	12	have	have	VBP
cord-016293-pyb00pt5	420	13	been	be	VBN
cord-016293-pyb00pt5	420	14	termed	term	VBN
cord-016293-pyb00pt5	420	15	proteomics	proteomic	NNS
cord-016293-pyb00pt5	420	16	and	and	CC
cord-016293-pyb00pt5	420	17	metabolomics	metabolomic	NNS
cord-016293-pyb00pt5	420	18	,	,	,
cord-016293-pyb00pt5	420	19	which	which	WDT
cord-016293-pyb00pt5	420	20	are	be	VBP
cord-016293-pyb00pt5	420	21	the	the	DT
cord-016293-pyb00pt5	420	22	global	global	JJ
cord-016293-pyb00pt5	420	23	studies	study	NNS
cord-016293-pyb00pt5	420	24	of	of	IN
cord-016293-pyb00pt5	420	25	gene	gene	NN
cord-016293-pyb00pt5	420	26	expression	expression	NN
cord-016293-pyb00pt5	420	27	at	at	IN
cord-016293-pyb00pt5	420	28	the	the	DT
cord-016293-pyb00pt5	420	29	protein	protein	NN
cord-016293-pyb00pt5	420	30	and	and	CC
cord-016293-pyb00pt5	420	31	metabolite	metabolite	JJ
cord-016293-pyb00pt5	420	32	levels	level	NNS
cord-016293-pyb00pt5	420	33	respectively	respectively	RB
cord-016293-pyb00pt5	420	34	.	.	.
cord-016293-pyb00pt5	421	1	The	the	DT
cord-016293-pyb00pt5	421	2	study	study	NN
cord-016293-pyb00pt5	421	3	of	of	IN
cord-016293-pyb00pt5	421	4	the	the	DT
cord-016293-pyb00pt5	421	5	integration	integration	NN
cord-016293-pyb00pt5	421	6	of	of	IN
cord-016293-pyb00pt5	421	7	information	information	NN
cord-016293-pyb00pt5	421	8	flow	flow	NN
cord-016293-pyb00pt5	421	9	within	within	IN
cord-016293-pyb00pt5	421	10	an	an	DT
cord-016293-pyb00pt5	421	11	organism	organism	NN
cord-016293-pyb00pt5	421	12	is	be	VBZ
cord-016293-pyb00pt5	421	13	emerging	emerge	VBG
cord-016293-pyb00pt5	421	14	as	as	IN
cord-016293-pyb00pt5	421	15	the	the	DT
cord-016293-pyb00pt5	421	16	field	field	NN
cord-016293-pyb00pt5	421	17	of	of	IN
cord-016293-pyb00pt5	421	18	systems	system	NNS
cord-016293-pyb00pt5	421	19	biology	biology	NN
cord-016293-pyb00pt5	421	20	.	.	.
cord-016293-pyb00pt5	422	1	In	in	IN
cord-016293-pyb00pt5	422	2	the	the	DT
cord-016293-pyb00pt5	422	3	area	area	NN
cord-016293-pyb00pt5	422	4	of	of	IN
cord-016293-pyb00pt5	422	5	proteomics	proteomic	NNS
cord-016293-pyb00pt5	422	6	,	,	,
cord-016293-pyb00pt5	422	7	the	the	DT
cord-016293-pyb00pt5	422	8	methods	method	NNS
cord-016293-pyb00pt5	422	9	for	for	IN
cord-016293-pyb00pt5	422	10	global	global	JJ
cord-016293-pyb00pt5	422	11	analysis	analysis	NN
cord-016293-pyb00pt5	422	12	of	of	IN
cord-016293-pyb00pt5	422	13	protein	protein	NN
cord-016293-pyb00pt5	422	14	profiles	profile	NNS
cord-016293-pyb00pt5	422	15	and	and	CC
cord-016293-pyb00pt5	422	16	cataloging	catalog	VBG
cord-016293-pyb00pt5	422	17	protein	protein	NN
cord-016293-pyb00pt5	422	18	-	-	HYPH
cord-016293-pyb00pt5	422	19	protein	protein	NN
cord-016293-pyb00pt5	422	20	interactions	interaction	NNS
cord-016293-pyb00pt5	422	21	on	on	IN
cord-016293-pyb00pt5	422	22	a	a	DT
cord-016293-pyb00pt5	422	23	genome	genome	NN
cord-016293-pyb00pt5	422	24	-	-	HYPH
cord-016293-pyb00pt5	422	25	wide	wide	JJ
cord-016293-pyb00pt5	422	26	scale	scale	NN
cord-016293-pyb00pt5	422	27	are	be	VBP
cord-016293-pyb00pt5	422	28	technically	technically	RB
cord-016293-pyb00pt5	422	29	more	more	RBR
cord-016293-pyb00pt5	422	30	difficult	difficult	JJ
cord-016293-pyb00pt5	422	31	but	but	CC
cord-016293-pyb00pt5	422	32	improving	improve	VBG
cord-016293-pyb00pt5	422	33	rapidly	rapidly	RB
cord-016293-pyb00pt5	422	34	,	,	,
cord-016293-pyb00pt5	422	35	especially	especially	RB
cord-016293-pyb00pt5	422	36	for	for	IN
cord-016293-pyb00pt5	422	37	microbes	microbe	NNS
cord-016293-pyb00pt5	422	38	.	.	.
cord-016293-pyb00pt5	423	1	These	these	DT
cord-016293-pyb00pt5	423	2	approaches	approach	NNS
cord-016293-pyb00pt5	423	3	generate	generate	VBP
cord-016293-pyb00pt5	423	4	vast	vast	JJ
cord-016293-pyb00pt5	423	5	amounts	amount	NNS
cord-016293-pyb00pt5	423	6	of	of	IN
cord-016293-pyb00pt5	423	7	quantitative	quantitative	JJ
cord-016293-pyb00pt5	423	8	data	datum	NNS
cord-016293-pyb00pt5	423	9	.	.	.
cord-016293-pyb00pt5	424	1	The	the	DT
cord-016293-pyb00pt5	424	2	amount	amount	NN
cord-016293-pyb00pt5	424	3	of	of	IN
cord-016293-pyb00pt5	424	4	expression	expression	NN
cord-016293-pyb00pt5	424	5	data	datum	NNS
cord-016293-pyb00pt5	424	6	becoming	become	VBG
cord-016293-pyb00pt5	424	7	available	available	JJ
cord-016293-pyb00pt5	424	8	in	in	IN
cord-016293-pyb00pt5	424	9	the	the	DT
cord-016293-pyb00pt5	424	10	public	public	JJ
cord-016293-pyb00pt5	424	11	and	and	CC
cord-016293-pyb00pt5	424	12	private	private	JJ
cord-016293-pyb00pt5	424	13	sectors	sector	NNS
cord-016293-pyb00pt5	424	14	is	be	VBZ
cord-016293-pyb00pt5	424	15	already	already	RB
cord-016293-pyb00pt5	424	16	increasing	increase	VBG
cord-016293-pyb00pt5	424	17	exponentially	exponentially	RB
cord-016293-pyb00pt5	424	18	.	.	.
cord-016293-pyb00pt5	425	1	Gene	gene	NN
cord-016293-pyb00pt5	425	2	and	and	CC
cord-016293-pyb00pt5	425	3	protein	protein	NN
cord-016293-pyb00pt5	425	4	expression	expression	NN
cord-016293-pyb00pt5	425	5	data	datum	NNS
cord-016293-pyb00pt5	425	6	rapidly	rapidly	RB
cord-016293-pyb00pt5	425	7	dwarfed	dwarf	VBD
cord-016293-pyb00pt5	425	8	the	the	DT
cord-016293-pyb00pt5	425	9	DNA	dna	NN
cord-016293-pyb00pt5	425	10	sequence	sequence	NN
cord-016293-pyb00pt5	425	11	data	datum	NNS
cord-016293-pyb00pt5	425	12	and	and	CC
cord-016293-pyb00pt5	425	13	is	be	VBZ
cord-016293-pyb00pt5	425	14	considerably	considerably	RB
cord-016293-pyb00pt5	425	15	more	more	RBR
cord-016293-pyb00pt5	425	16	difficult	difficult	JJ
cord-016293-pyb00pt5	425	17	to	to	TO
cord-016293-pyb00pt5	425	18	manage	manage	VB
cord-016293-pyb00pt5	425	19	and	and	CC
cord-016293-pyb00pt5	425	20	exploit	exploit	VB
cord-016293-pyb00pt5	425	21	.	.	.
cord-016293-pyb00pt5	426	1	In	in	IN
cord-016293-pyb00pt5	426	2	microbes	microbe	NNS
cord-016293-pyb00pt5	426	3	,	,	,
cord-016293-pyb00pt5	426	4	the	the	DT
cord-016293-pyb00pt5	426	5	small	small	JJ
cord-016293-pyb00pt5	426	6	sizes	size	NNS
cord-016293-pyb00pt5	426	7	of	of	IN
cord-016293-pyb00pt5	426	8	the	the	DT
cord-016293-pyb00pt5	426	9	genomes	genome	NNS
cord-016293-pyb00pt5	426	10	and	and	CC
cord-016293-pyb00pt5	426	11	the	the	DT
cord-016293-pyb00pt5	426	12	ease	ease	NN
cord-016293-pyb00pt5	426	13	of	of	IN
cord-016293-pyb00pt5	426	14	handling	handle	VBG
cord-016293-pyb00pt5	426	15	microbial	microbial	JJ
cord-016293-pyb00pt5	426	16	cultures	culture	NNS
cord-016293-pyb00pt5	426	17	,	,	,
cord-016293-pyb00pt5	426	18	will	will	MD
cord-016293-pyb00pt5	426	19	enable	enable	VB
cord-016293-pyb00pt5	426	20	high	high	JJ
cord-016293-pyb00pt5	426	21	throughput	throughput	NN
cord-016293-pyb00pt5	426	22	,	,	,
cord-016293-pyb00pt5	426	23	targeted	target	VBN
cord-016293-pyb00pt5	426	24	deletion	deletion	NN
cord-016293-pyb00pt5	426	25	of	of	IN
cord-016293-pyb00pt5	426	26	every	every	DT
cord-016293-pyb00pt5	426	27	gene	gene	NN
cord-016293-pyb00pt5	426	28	in	in	IN
cord-016293-pyb00pt5	426	29	a	a	DT
cord-016293-pyb00pt5	426	30	genome	genome	NN
cord-016293-pyb00pt5	426	31	,	,	,
cord-016293-pyb00pt5	426	32	individually	individually	RB
cord-016293-pyb00pt5	426	33	and	and	CC
cord-016293-pyb00pt5	426	34	in	in	IN
cord-016293-pyb00pt5	426	35	combinations	combination	NNS
cord-016293-pyb00pt5	426	36	.	.	.
cord-016293-pyb00pt5	427	1	This	this	DT
cord-016293-pyb00pt5	427	2	is	be	VBZ
cord-016293-pyb00pt5	427	3	already	already	RB
cord-016293-pyb00pt5	427	4	available	available	JJ
cord-016293-pyb00pt5	427	5	on	on	IN
cord-016293-pyb00pt5	427	6	a	a	DT
cord-016293-pyb00pt5	427	7	moderate	moderate	JJ
cord-016293-pyb00pt5	427	8	throughput	throughput	NN
cord-016293-pyb00pt5	427	9	scale	scale	NN
cord-016293-pyb00pt5	427	10	in	in	IN
cord-016293-pyb00pt5	427	11	model	model	NN
cord-016293-pyb00pt5	427	12	microbes	microbe	NNS
cord-016293-pyb00pt5	427	13	such	such	JJ
cord-016293-pyb00pt5	427	14	as	as	IN
cord-016293-pyb00pt5	427	15	E.	E.	NNP
cord-016293-pyb00pt5	427	16	coli	coli	NNS
cord-016293-pyb00pt5	427	17	and	and	CC
cord-016293-pyb00pt5	427	18	yeast	yeast	NN
cord-016293-pyb00pt5	427	19	.	.	.
cord-016293-pyb00pt5	428	1	Combining	combine	VBG
cord-016293-pyb00pt5	428	2	targeted	target	VBN
cord-016293-pyb00pt5	428	3	gene	gene	NN
cord-016293-pyb00pt5	428	4	deletions	deletion	NNS
cord-016293-pyb00pt5	428	5	and	and	CC
cord-016293-pyb00pt5	428	6	modifications	modification	NNS
cord-016293-pyb00pt5	428	7	with	with	IN
cord-016293-pyb00pt5	428	8	genome	genome	NN
cord-016293-pyb00pt5	428	9	-	-	HYPH
cord-016293-pyb00pt5	428	10	wide	wide	JJ
cord-016293-pyb00pt5	428	11	assay	assay	NN
cord-016293-pyb00pt5	428	12	of	of	IN
cord-016293-pyb00pt5	428	13	mRNA	mrna	NN
cord-016293-pyb00pt5	428	14	and	and	CC
cord-016293-pyb00pt5	428	15	protein	protein	NN
cord-016293-pyb00pt5	428	16	levels	level	NNS
cord-016293-pyb00pt5	428	17	will	will	MD
cord-016293-pyb00pt5	428	18	enable	enable	VB
cord-016293-pyb00pt5	428	19	intricate	intricate	JJ
cord-016293-pyb00pt5	428	20	inter	inter	JJ
cord-016293-pyb00pt5	428	21	-	-	NNS
cord-016293-pyb00pt5	428	22	dependencies	dependency	NNS
cord-016293-pyb00pt5	428	23	among	among	IN
cord-016293-pyb00pt5	428	24	genes	gene	NNS
cord-016293-pyb00pt5	428	25	to	to	TO
cord-016293-pyb00pt5	428	26	be	be	VB
cord-016293-pyb00pt5	428	27	unraveled	unravel	VBN
cord-016293-pyb00pt5	428	28	.	.	.
cord-016293-pyb00pt5	429	1	Simultaneous	simultaneous	JJ
cord-016293-pyb00pt5	429	2	measurement	measurement	NN
cord-016293-pyb00pt5	429	3	of	of	IN
cord-016293-pyb00pt5	429	4	many	many	JJ
cord-016293-pyb00pt5	429	5	metabolites	metabolite	NNS
cord-016293-pyb00pt5	429	6	,	,	,
cord-016293-pyb00pt5	429	7	particularly	particularly	RB
cord-016293-pyb00pt5	429	8	in	in	IN
cord-016293-pyb00pt5	429	9	microbes	microbe	NNS
cord-016293-pyb00pt5	429	10	,	,	,
cord-016293-pyb00pt5	429	11	is	be	VBZ
cord-016293-pyb00pt5	429	12	beginning	begin	VBG
cord-016293-pyb00pt5	429	13	to	to	TO
cord-016293-pyb00pt5	429	14	allow	allow	VB
cord-016293-pyb00pt5	429	15	the	the	DT
cord-016293-pyb00pt5	429	16	comprehensive	comprehensive	JJ
cord-016293-pyb00pt5	429	17	modeling	modeling	NN
cord-016293-pyb00pt5	429	18	and	and	CC
cord-016293-pyb00pt5	429	19	regulation	regulation	NN
cord-016293-pyb00pt5	429	20	of	of	IN
cord-016293-pyb00pt5	429	21	fluxes	flux	NNS
cord-016293-pyb00pt5	429	22	through	through	IN
cord-016293-pyb00pt5	429	23	interdependent	interdependent	JJ
cord-016293-pyb00pt5	429	24	pathways	pathway	NNS
cord-016293-pyb00pt5	429	25	.	.	.
cord-016293-pyb00pt5	430	1	Metabolomics	metabolomic	NNS
cord-016293-pyb00pt5	430	2	can	can	MD
cord-016293-pyb00pt5	430	3	be	be	VB
cord-016293-pyb00pt5	430	4	defined	define	VBN
cord-016293-pyb00pt5	430	5	as	as	IN
cord-016293-pyb00pt5	430	6	the	the	DT
cord-016293-pyb00pt5	430	7	quantitative	quantitative	JJ
cord-016293-pyb00pt5	430	8	measurement	measurement	NN
cord-016293-pyb00pt5	430	9	of	of	IN
cord-016293-pyb00pt5	430	10	all	all	DT
cord-016293-pyb00pt5	430	11	low	low	JJ
cord-016293-pyb00pt5	430	12	molecular	molecular	JJ
cord-016293-pyb00pt5	430	13	weight	weight	NN
cord-016293-pyb00pt5	430	14	metabolites	metabolite	NNS
cord-016293-pyb00pt5	430	15	in	in	IN
cord-016293-pyb00pt5	430	16	an	an	DT
cord-016293-pyb00pt5	430	17	organism	organism	NN
cord-016293-pyb00pt5	430	18	's	's	POS
cord-016293-pyb00pt5	430	19	cells	cell	NNS
cord-016293-pyb00pt5	430	20	at	at	IN
cord-016293-pyb00pt5	430	21	a	a	DT
cord-016293-pyb00pt5	430	22	specified	specify	VBN
cord-016293-pyb00pt5	430	23	time	time	NN
cord-016293-pyb00pt5	430	24	under	under	IN
cord-016293-pyb00pt5	430	25	specific	specific	JJ
cord-016293-pyb00pt5	430	26	environmental	environmental	JJ
cord-016293-pyb00pt5	430	27	conditions	condition	NNS
cord-016293-pyb00pt5	430	28	.	.	.
cord-016293-pyb00pt5	431	1	Combining	combine	VBG
cord-016293-pyb00pt5	431	2	information	information	NN
cord-016293-pyb00pt5	431	3	from	from	IN
cord-016293-pyb00pt5	431	4	metabolomics	metabolomic	NNS
cord-016293-pyb00pt5	431	5	,	,	,
cord-016293-pyb00pt5	431	6	proteomics	proteomic	NNS
cord-016293-pyb00pt5	431	7	and	and	CC
cord-016293-pyb00pt5	431	8	genomics	genomic	NNS
cord-016293-pyb00pt5	431	9	will	will	MD
cord-016293-pyb00pt5	431	10	help	help	VB
cord-016293-pyb00pt5	431	11	us	-PRON-	PRP
cord-016293-pyb00pt5	431	12	to	to	TO
cord-016293-pyb00pt5	431	13	obtain	obtain	VB
cord-016293-pyb00pt5	431	14	an	an	DT
cord-016293-pyb00pt5	431	15	integrated	integrated	JJ
cord-016293-pyb00pt5	431	16	understanding	understanding	NN
cord-016293-pyb00pt5	431	17	of	of	IN
cord-016293-pyb00pt5	431	18	cell	cell	NN
cord-016293-pyb00pt5	431	19	biology	biology	NN
cord-016293-pyb00pt5	431	20	.	.	.
cord-016293-pyb00pt5	432	1	The	the	DT
cord-016293-pyb00pt5	432	2	next	next	JJ
cord-016293-pyb00pt5	432	3	hierarchical	hierarchical	JJ
cord-016293-pyb00pt5	432	4	level	level	NN
cord-016293-pyb00pt5	432	5	of	of	IN
cord-016293-pyb00pt5	432	6	phenotype	phenotype	NN
cord-016293-pyb00pt5	432	7	considers	consider	VBZ
cord-016293-pyb00pt5	432	8	how	how	WRB
cord-016293-pyb00pt5	432	9	the	the	DT
cord-016293-pyb00pt5	432	10	proteome	proteome	NN
cord-016293-pyb00pt5	432	11	within	within	IN
cord-016293-pyb00pt5	432	12	and	and	CC
cord-016293-pyb00pt5	432	13	among	among	IN
cord-016293-pyb00pt5	432	14	cells	cell	NNS
cord-016293-pyb00pt5	432	15	cooperates	cooperate	VBZ
cord-016293-pyb00pt5	432	16	to	to	TO
cord-016293-pyb00pt5	432	17	produce	produce	VB
cord-016293-pyb00pt5	432	18	the	the	DT
cord-016293-pyb00pt5	432	19	biochemistry	biochemistry	NN
cord-016293-pyb00pt5	432	20	and	and	CC
cord-016293-pyb00pt5	432	21	physiology	physiology	NN
cord-016293-pyb00pt5	432	22	of	of	IN
cord-016293-pyb00pt5	432	23	individual	individual	JJ
cord-016293-pyb00pt5	432	24	cells	cell	NNS
cord-016293-pyb00pt5	432	25	and	and	CC
cord-016293-pyb00pt5	432	26	organisms	organism	NNS
cord-016293-pyb00pt5	432	27	.	.	.
cord-016293-pyb00pt5	433	1	Several	several	JJ
cord-016293-pyb00pt5	433	2	authors	author	NNS
cord-016293-pyb00pt5	433	3	have	have	VBP
cord-016293-pyb00pt5	433	4	tentatively	tentatively	RB
cord-016293-pyb00pt5	433	5	offered	offer	VBN
cord-016293-pyb00pt5	433	6	"	"	``
cord-016293-pyb00pt5	433	7	physiomics	physiomic	NNS
cord-016293-pyb00pt5	433	8	"	"	''
cord-016293-pyb00pt5	433	9	as	as	IN
cord-016293-pyb00pt5	433	10	a	a	DT
cord-016293-pyb00pt5	433	11	descriptor	descriptor	NN
cord-016293-pyb00pt5	433	12	for	for	IN
cord-016293-pyb00pt5	433	13	this	this	DT
cord-016293-pyb00pt5	433	14	approach	approach	NN
cord-016293-pyb00pt5	433	15	.	.	.
cord-016293-pyb00pt5	434	1	The	the	DT
cord-016293-pyb00pt5	434	2	final	final	JJ
cord-016293-pyb00pt5	434	3	hierarchical	hierarchical	JJ
cord-016293-pyb00pt5	434	4	levels	level	NNS
cord-016293-pyb00pt5	434	5	of	of	IN
cord-016293-pyb00pt5	434	6	phenotype	phenotype	NN
cord-016293-pyb00pt5	434	7	include	include	VBP
cord-016293-pyb00pt5	434	8	anatomy	anatomy	NN
cord-016293-pyb00pt5	434	9	and	and	CC
cord-016293-pyb00pt5	434	10	function	function	NN
cord-016293-pyb00pt5	434	11	for	for	IN
cord-016293-pyb00pt5	434	12	cells	cell	NNS
cord-016293-pyb00pt5	434	13	and	and	CC
cord-016293-pyb00pt5	434	14	whole	whole	JJ
cord-016293-pyb00pt5	434	15	organisms	organism	NNS
cord-016293-pyb00pt5	434	16	.	.	.
cord-016293-pyb00pt5	435	1	The	the	DT
cord-016293-pyb00pt5	435	2	term	term	NN
cord-016293-pyb00pt5	435	3	"	"	``
cord-016293-pyb00pt5	435	4	phenomics	phenomic	NNS
cord-016293-pyb00pt5	435	5	"	"	''
cord-016293-pyb00pt5	435	6	has	have	VBZ
cord-016293-pyb00pt5	435	7	been	be	VBN
cord-016293-pyb00pt5	435	8	applied	apply	VBN
cord-016293-pyb00pt5	435	9	to	to	IN
cord-016293-pyb00pt5	435	10	this	this	DT
cord-016293-pyb00pt5	435	11	level	level	NN
cord-016293-pyb00pt5	435	12	of	of	IN
cord-016293-pyb00pt5	435	13	study	study	NN
cord-016293-pyb00pt5	435	14	and	and	CC
cord-016293-pyb00pt5	435	15	unquestionably	unquestionably	RB
cord-016293-pyb00pt5	435	16	the	the	DT
cord-016293-pyb00pt5	435	17	more	more	RBR
cord-016293-pyb00pt5	435	18	well	well	RB
cord-016293-pyb00pt5	435	19	known	know	VBN
cord-016293-pyb00pt5	435	20	omics	omic	NNS
cord-016293-pyb00pt5	435	21	namely	namely	RB
cord-016293-pyb00pt5	435	22	economics	economics	NNP
cord-016293-pyb00pt5	435	23	,	,	,
cord-016293-pyb00pt5	435	24	has	have	VBZ
cord-016293-pyb00pt5	435	25	application	application	NN
cord-016293-pyb00pt5	435	26	across	across	IN
cord-016293-pyb00pt5	435	27	all	all	PDT
cord-016293-pyb00pt5	435	28	those	those	DT
cord-016293-pyb00pt5	435	29	fields	field	NNS
cord-016293-pyb00pt5	435	30	.	.	.
cord-016293-pyb00pt5	436	1	And	and	CC
cord-016293-pyb00pt5	436	2	,	,	,
cord-016293-pyb00pt5	436	3	coming	come	VBG
cord-016293-pyb00pt5	436	4	slightly	slightly	RB
cord-016293-pyb00pt5	436	5	out	out	IN
cord-016293-pyb00pt5	436	6	of	of	IN
cord-016293-pyb00pt5	436	7	left	left	JJ
cord-016293-pyb00pt5	436	8	field	field	NN
cord-016293-pyb00pt5	436	9	this	this	DT
cord-016293-pyb00pt5	436	10	time	time	NN
cord-016293-pyb00pt5	436	11	,	,	,
cord-016293-pyb00pt5	436	12	the	the	DT
cord-016293-pyb00pt5	436	13	spectre	spectre	NN
cord-016293-pyb00pt5	436	14	of	of	IN
cord-016293-pyb00pt5	436	15	eugenics	eugenics	NN
cord-016293-pyb00pt5	436	16	needless	needless	JJ
cord-016293-pyb00pt5	436	17	to	to	TO
cord-016293-pyb00pt5	436	18	say	say	VB
cord-016293-pyb00pt5	436	19	was	be	VBD
cord-016293-pyb00pt5	436	20	raised	raise	VBN
cord-016293-pyb00pt5	436	21	in	in	IN
cord-016293-pyb00pt5	436	22	the	the	DT
cord-016293-pyb00pt5	436	23	omics	omic	NNS
cord-016293-pyb00pt5	436	24	era	era	NN
cord-016293-pyb00pt5	436	25	.	.	.
cord-016293-pyb00pt5	437	1	In	in	IN
cord-016293-pyb00pt5	437	2	the	the	DT
cord-016293-pyb00pt5	437	3	year	year	NN
cord-016293-pyb00pt5	437	4	1992	1992	CD
cord-016293-pyb00pt5	437	5	American	american	JJ
cord-016293-pyb00pt5	437	6	and	and	CC
cord-016293-pyb00pt5	437	7	British	british	JJ
cord-016293-pyb00pt5	437	8	scientists	scientist	NNS
cord-016293-pyb00pt5	437	9	unveiled	unveil	VBD
cord-016293-pyb00pt5	437	10	a	a	DT
cord-016293-pyb00pt5	437	11	technique	technique	NN
cord-016293-pyb00pt5	437	12	which	which	WDT
cord-016293-pyb00pt5	437	13	has	have	VBZ
cord-016293-pyb00pt5	437	14	come	come	VBN
cord-016293-pyb00pt5	437	15	to	to	TO
cord-016293-pyb00pt5	437	16	be	be	VB
cord-016293-pyb00pt5	437	17	known	know	VBN
cord-016293-pyb00pt5	437	18	as	as	IN
cord-016293-pyb00pt5	437	19	pre	pre	JJ
cord-016293-pyb00pt5	437	20	-	-	JJ
cord-016293-pyb00pt5	437	21	implantation	implantation	JJ
cord-016293-pyb00pt5	437	22	genetic	genetic	JJ
cord-016293-pyb00pt5	437	23	diagnosis	diagnosis	NN
cord-016293-pyb00pt5	437	24	(	(	-LRB-
cord-016293-pyb00pt5	437	25	PID	PID	NNP
cord-016293-pyb00pt5	437	26	)	)	-RRB-
cord-016293-pyb00pt5	437	27	for	for	IN
cord-016293-pyb00pt5	437	28	testing	test	VBG
cord-016293-pyb00pt5	437	29	embryos	embryo	NNS
cord-016293-pyb00pt5	437	30	in	in	IN
cord-016293-pyb00pt5	437	31	vitro	vitro	FW
cord-016293-pyb00pt5	437	32	for	for	IN
cord-016293-pyb00pt5	437	33	genetic	genetic	JJ
cord-016293-pyb00pt5	437	34	abnormalities	abnormality	NNS
cord-016293-pyb00pt5	437	35	such	such	JJ
cord-016293-pyb00pt5	437	36	as	as	IN
cord-016293-pyb00pt5	437	37	cystic	cystic	JJ
cord-016293-pyb00pt5	437	38	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	437	39	,	,	,
cord-016293-pyb00pt5	437	40	hemophilia	hemophilia	NN
cord-016293-pyb00pt5	437	41	,	,	,
cord-016293-pyb00pt5	437	42	and	and	CC
cord-016293-pyb00pt5	437	43	Down	Down	NNP
cord-016293-pyb00pt5	437	44	's	's	POS
cord-016293-pyb00pt5	437	45	Syndrome	Syndrome	NNP
cord-016293-pyb00pt5	437	46	(	(	-LRB-
cord-016293-pyb00pt5	437	47	Wald	Wald	NNP
cord-016293-pyb00pt5	437	48	,	,	,
cord-016293-pyb00pt5	437	49	1992	1992	CD
cord-016293-pyb00pt5	437	50	)	)	-RRB-
cord-016293-pyb00pt5	437	51	.	.	.
cord-016293-pyb00pt5	438	1	This	this	DT
cord-016293-pyb00pt5	438	2	might	may	MD
cord-016293-pyb00pt5	438	3	be	be	VB
cord-016293-pyb00pt5	438	4	seen	see	VBN
cord-016293-pyb00pt5	438	5	by	by	IN
cord-016293-pyb00pt5	438	6	most	most	JJS
cord-016293-pyb00pt5	438	7	as	as	IN
cord-016293-pyb00pt5	438	8	a	a	DT
cord-016293-pyb00pt5	438	9	step	step	NN
cord-016293-pyb00pt5	438	10	forward	forward	RB
cord-016293-pyb00pt5	438	11	,	,	,
cord-016293-pyb00pt5	438	12	but	but	CC
cord-016293-pyb00pt5	438	13	it	-PRON-	PRP
cord-016293-pyb00pt5	438	14	led	lead	VBD
cord-016293-pyb00pt5	438	15	ethicist	ethicist	NN
cord-016293-pyb00pt5	438	16	David	David	NNP
cord-016293-pyb00pt5	438	17	S.	S.	NNP
cord-016293-pyb00pt5	438	18	King	King	NNP
cord-016293-pyb00pt5	438	19	(	(	-LRB-
cord-016293-pyb00pt5	438	20	1999	1999	CD
cord-016293-pyb00pt5	438	21	)	)	-RRB-
cord-016293-pyb00pt5	438	22	to	to	TO
cord-016293-pyb00pt5	438	23	decry	decry	VB
cord-016293-pyb00pt5	438	24	PID	PID	NNP
cord-016293-pyb00pt5	438	25	as	as	IN
cord-016293-pyb00pt5	438	26	a	a	DT
cord-016293-pyb00pt5	438	27	technology	technology	NN
cord-016293-pyb00pt5	438	28	that	that	WDT
cord-016293-pyb00pt5	438	29	could	could	MD
cord-016293-pyb00pt5	438	30	exacerbate	exacerbate	VB
cord-016293-pyb00pt5	438	31	the	the	DT
cord-016293-pyb00pt5	438	32	eugenic	eugenic	JJ
cord-016293-pyb00pt5	438	33	features	feature	NNS
cord-016293-pyb00pt5	438	34	of	of	IN
cord-016293-pyb00pt5	438	35	prenatal	prenatal	JJ
cord-016293-pyb00pt5	438	36	testing	testing	NN
cord-016293-pyb00pt5	438	37	and	and	CC
cord-016293-pyb00pt5	438	38	make	make	VB
cord-016293-pyb00pt5	438	39	possible	possible	JJ
cord-016293-pyb00pt5	438	40	an	an	DT
cord-016293-pyb00pt5	438	41	expanded	expand	VBN
cord-016293-pyb00pt5	438	42	form	form	NN
cord-016293-pyb00pt5	438	43	of	of	IN
cord-016293-pyb00pt5	438	44	free	free	JJ
cord-016293-pyb00pt5	438	45	-	-	HYPH
cord-016293-pyb00pt5	438	46	market	market	NN
cord-016293-pyb00pt5	438	47	eugenics	eugenics	NN
cord-016293-pyb00pt5	438	48	.	.	.
cord-016293-pyb00pt5	439	1	He	-PRON-	PRP
cord-016293-pyb00pt5	439	2	further	further	RB
cord-016293-pyb00pt5	439	3	argues	argue	VBZ
cord-016293-pyb00pt5	439	4	that	that	IN
cord-016293-pyb00pt5	439	5	due	due	IN
cord-016293-pyb00pt5	439	6	to	to	IN
cord-016293-pyb00pt5	439	7	social	social	JJ
cord-016293-pyb00pt5	439	8	pressures	pressure	NNS
cord-016293-pyb00pt5	439	9	and	and	CC
cord-016293-pyb00pt5	439	10	eugenic	eugenic	JJ
cord-016293-pyb00pt5	439	11	attitudes	attitude	NNS
cord-016293-pyb00pt5	439	12	held	hold	VBN
cord-016293-pyb00pt5	439	13	by	by	IN
cord-016293-pyb00pt5	439	14	clinical	clinical	JJ
cord-016293-pyb00pt5	439	15	geneticists	geneticist	NNS
cord-016293-pyb00pt5	439	16	in	in	IN
cord-016293-pyb00pt5	439	17	most	most	JJS
cord-016293-pyb00pt5	439	18	countries	country	NNS
cord-016293-pyb00pt5	439	19	,	,	,
cord-016293-pyb00pt5	439	20	it	-PRON-	PRP
cord-016293-pyb00pt5	439	21	results	result	VBZ
cord-016293-pyb00pt5	439	22	in	in	IN
cord-016293-pyb00pt5	439	23	eugenic	eugenic	JJ
cord-016293-pyb00pt5	439	24	outcomes	outcome	NNS
cord-016293-pyb00pt5	439	25	even	even	RB
cord-016293-pyb00pt5	439	26	though	though	IN
cord-016293-pyb00pt5	439	27	no	no	DT
cord-016293-pyb00pt5	439	28	state	state	NN
cord-016293-pyb00pt5	439	29	coercion	coercion	NN
cord-016293-pyb00pt5	439	30	is	be	VBZ
cord-016293-pyb00pt5	439	31	involved	involve	VBN
cord-016293-pyb00pt5	439	32	and	and	CC
cord-016293-pyb00pt5	439	33	that	that	IN
cord-016293-pyb00pt5	439	34	,	,	,
cord-016293-pyb00pt5	439	35	as	as	IN
cord-016293-pyb00pt5	439	36	abortion	abortion	NN
cord-016293-pyb00pt5	439	37	is	be	VBZ
cord-016293-pyb00pt5	439	38	not	not	RB
cord-016293-pyb00pt5	439	39	involved	involve	VBN
cord-016293-pyb00pt5	439	40	,	,	,
cord-016293-pyb00pt5	439	41	and	and	CC
cord-016293-pyb00pt5	439	42	multiple	multiple	JJ
cord-016293-pyb00pt5	439	43	embryos	embryo	NNS
cord-016293-pyb00pt5	439	44	are	be	VBP
cord-016293-pyb00pt5	439	45	available	available	JJ
cord-016293-pyb00pt5	439	46	,	,	,
cord-016293-pyb00pt5	439	47	PID	PID	NNP
cord-016293-pyb00pt5	439	48	is	be	VBZ
cord-016293-pyb00pt5	439	49	radically	radically	RB
cord-016293-pyb00pt5	439	50	more	more	RBR
cord-016293-pyb00pt5	439	51	effective	effective	JJ
cord-016293-pyb00pt5	439	52	as	as	IN
cord-016293-pyb00pt5	439	53	a	a	DT
cord-016293-pyb00pt5	439	54	tool	tool	NN
cord-016293-pyb00pt5	439	55	of	of	IN
cord-016293-pyb00pt5	439	56	genetic	genetic	JJ
cord-016293-pyb00pt5	439	57	selection	selection	NN
cord-016293-pyb00pt5	439	58	.	.	.
cord-016293-pyb00pt5	440	1	The	the	DT
cord-016293-pyb00pt5	440	2	first	first	JJ
cord-016293-pyb00pt5	440	3	regulatory	regulatory	JJ
cord-016293-pyb00pt5	440	4	approval	approval	NN
cord-016293-pyb00pt5	440	5	of	of	IN
cord-016293-pyb00pt5	440	6	a	a	DT
cord-016293-pyb00pt5	440	7	recombinant	recombinant	JJ
cord-016293-pyb00pt5	440	8	DNA	dna	NN
cord-016293-pyb00pt5	440	9	technology	technology	NN
cord-016293-pyb00pt5	440	10	in	in	IN
cord-016293-pyb00pt5	440	11	the	the	DT
cord-016293-pyb00pt5	440	12	U.S.	U.S.	NNP
cord-016293-pyb00pt5	440	13	food	food	NN
cord-016293-pyb00pt5	440	14	supply	supply	NN
cord-016293-pyb00pt5	440	15	was	be	VBD
cord-016293-pyb00pt5	440	16	not	not	RB
cord-016293-pyb00pt5	440	17	a	a	DT
cord-016293-pyb00pt5	440	18	plant	plant	NN
cord-016293-pyb00pt5	440	19	but	but	CC
cord-016293-pyb00pt5	440	20	an	an	DT
cord-016293-pyb00pt5	440	21	industrial	industrial	JJ
cord-016293-pyb00pt5	440	22	enzyme	enzyme	NN
cord-016293-pyb00pt5	440	23	that	that	WDT
cord-016293-pyb00pt5	440	24	has	have	VBZ
cord-016293-pyb00pt5	440	25	become	become	VBN
cord-016293-pyb00pt5	440	26	the	the	DT
cord-016293-pyb00pt5	440	27	hallmark	hallmark	NN
cord-016293-pyb00pt5	440	28	of	of	IN
cord-016293-pyb00pt5	440	29	food	food	NN
cord-016293-pyb00pt5	440	30	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	440	31	success	success	NN
cord-016293-pyb00pt5	440	32	.	.	.
cord-016293-pyb00pt5	441	1	Enzymes	enzyme	NNS
cord-016293-pyb00pt5	441	2	were	be	VBD
cord-016293-pyb00pt5	441	3	important	important	JJ
cord-016293-pyb00pt5	441	4	agents	agent	NNS
cord-016293-pyb00pt5	441	5	in	in	IN
cord-016293-pyb00pt5	441	6	food	food	NN
cord-016293-pyb00pt5	441	7	production	production	NN
cord-016293-pyb00pt5	441	8	long	long	RB
cord-016293-pyb00pt5	441	9	before	before	IN
cord-016293-pyb00pt5	441	10	modern	modern	JJ
cord-016293-pyb00pt5	441	11	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	441	12	was	be	VBD
cord-016293-pyb00pt5	441	13	developed	develop	VBN
cord-016293-pyb00pt5	441	14	.	.	.
cord-016293-pyb00pt5	442	1	They	-PRON-	PRP
cord-016293-pyb00pt5	442	2	were	be	VBD
cord-016293-pyb00pt5	442	3	used	use	VBN
cord-016293-pyb00pt5	442	4	,	,	,
cord-016293-pyb00pt5	442	5	for	for	IN
cord-016293-pyb00pt5	442	6	instance	instance	NN
cord-016293-pyb00pt5	442	7	,	,	,
cord-016293-pyb00pt5	442	8	in	in	IN
cord-016293-pyb00pt5	442	9	the	the	DT
cord-016293-pyb00pt5	442	10	clotting	clotting	NN
cord-016293-pyb00pt5	442	11	of	of	IN
cord-016293-pyb00pt5	442	12	milk	milk	NN
cord-016293-pyb00pt5	442	13	to	to	TO
cord-016293-pyb00pt5	442	14	prepare	prepare	VB
cord-016293-pyb00pt5	442	15	cheese	cheese	NN
cord-016293-pyb00pt5	442	16	,	,	,
cord-016293-pyb00pt5	442	17	the	the	DT
cord-016293-pyb00pt5	442	18	production	production	NN
cord-016293-pyb00pt5	442	19	of	of	IN
cord-016293-pyb00pt5	442	20	bread	bread	NN
cord-016293-pyb00pt5	442	21	and	and	CC
cord-016293-pyb00pt5	442	22	the	the	DT
cord-016293-pyb00pt5	442	23	production	production	NN
cord-016293-pyb00pt5	442	24	of	of	IN
cord-016293-pyb00pt5	442	25	alcoholic	alcoholic	JJ
cord-016293-pyb00pt5	442	26	beverages	beverage	NNS
cord-016293-pyb00pt5	442	27	.	.	.
cord-016293-pyb00pt5	443	1	Nowadays	nowadays	RB
cord-016293-pyb00pt5	443	2	,	,	,
cord-016293-pyb00pt5	443	3	enzymes	enzyme	NNS
cord-016293-pyb00pt5	443	4	are	be	VBP
cord-016293-pyb00pt5	443	5	indispensable	indispensable	JJ
cord-016293-pyb00pt5	443	6	to	to	IN
cord-016293-pyb00pt5	443	7	modern	modern	JJ
cord-016293-pyb00pt5	443	8	food	food	NN
cord-016293-pyb00pt5	443	9	processing	processing	NN
cord-016293-pyb00pt5	443	10	technology	technology	NN
cord-016293-pyb00pt5	443	11	and	and	CC
cord-016293-pyb00pt5	443	12	have	have	VBP
cord-016293-pyb00pt5	443	13	a	a	DT
cord-016293-pyb00pt5	443	14	great	great	JJ
cord-016293-pyb00pt5	443	15	variety	variety	NN
cord-016293-pyb00pt5	443	16	of	of	IN
cord-016293-pyb00pt5	443	17	functions	function	NNS
cord-016293-pyb00pt5	443	18	.	.	.
cord-016293-pyb00pt5	444	1	They	-PRON-	PRP
cord-016293-pyb00pt5	444	2	are	be	VBP
cord-016293-pyb00pt5	444	3	used	use	VBN
cord-016293-pyb00pt5	444	4	in	in	IN
cord-016293-pyb00pt5	444	5	almost	almost	RB
cord-016293-pyb00pt5	444	6	all	all	DT
cord-016293-pyb00pt5	444	7	areas	area	NNS
cord-016293-pyb00pt5	444	8	of	of	IN
cord-016293-pyb00pt5	444	9	food	food	NN
cord-016293-pyb00pt5	444	10	production	production	NN
cord-016293-pyb00pt5	444	11	including	include	VBG
cord-016293-pyb00pt5	444	12	grain	grain	NN
cord-016293-pyb00pt5	444	13	processing	processing	NN
cord-016293-pyb00pt5	444	14	,	,	,
cord-016293-pyb00pt5	444	15	milk	milk	NN
cord-016293-pyb00pt5	444	16	products	product	NNS
cord-016293-pyb00pt5	444	17	,	,	,
cord-016293-pyb00pt5	444	18	beer	beer	NN
cord-016293-pyb00pt5	444	19	,	,	,
cord-016293-pyb00pt5	444	20	juices	juice	NNS
cord-016293-pyb00pt5	444	21	,	,	,
cord-016293-pyb00pt5	444	22	wine	wine	NN
cord-016293-pyb00pt5	444	23	,	,	,
cord-016293-pyb00pt5	444	24	sugar	sugar	NN
cord-016293-pyb00pt5	444	25	and	and	CC
cord-016293-pyb00pt5	444	26	meat	meat	NN
cord-016293-pyb00pt5	444	27	.	.	.
cord-016293-pyb00pt5	445	1	Chymosin	Chymosin	NNP
cord-016293-pyb00pt5	445	2	,	,	,
cord-016293-pyb00pt5	445	3	known	know	VBN
cord-016293-pyb00pt5	445	4	also	also	RB
cord-016293-pyb00pt5	445	5	as	as	IN
cord-016293-pyb00pt5	445	6	rennin	rennin	NN
cord-016293-pyb00pt5	445	7	,	,	,
cord-016293-pyb00pt5	445	8	is	be	VBZ
cord-016293-pyb00pt5	445	9	a	a	DT
cord-016293-pyb00pt5	445	10	proteolytic	proteolytic	JJ
cord-016293-pyb00pt5	445	11	enzyme	enzyme	NN
cord-016293-pyb00pt5	445	12	whose	whose	WP$
cord-016293-pyb00pt5	445	13	role	role	NN
cord-016293-pyb00pt5	445	14	in	in	IN
cord-016293-pyb00pt5	445	15	digestion	digestion	NN
cord-016293-pyb00pt5	445	16	is	be	VBZ
cord-016293-pyb00pt5	445	17	to	to	TO
cord-016293-pyb00pt5	445	18	curdle	curdle	VB
cord-016293-pyb00pt5	445	19	or	or	CC
cord-016293-pyb00pt5	445	20	coagulate	coagulate	VB
cord-016293-pyb00pt5	445	21	milk	milk	NN
cord-016293-pyb00pt5	445	22	in	in	IN
cord-016293-pyb00pt5	445	23	the	the	DT
cord-016293-pyb00pt5	445	24	stomach	stomach	NN
cord-016293-pyb00pt5	445	25	,	,	,
cord-016293-pyb00pt5	445	26	efficiently	efficiently	RB
cord-016293-pyb00pt5	445	27	converting	convert	VBG
cord-016293-pyb00pt5	445	28	liquid	liquid	JJ
cord-016293-pyb00pt5	445	29	milk	milk	NN
cord-016293-pyb00pt5	445	30	to	to	IN
cord-016293-pyb00pt5	445	31	a	a	DT
cord-016293-pyb00pt5	445	32	semisolid	semisolid	NN
cord-016293-pyb00pt5	445	33	like	like	IN
cord-016293-pyb00pt5	445	34	cottage	cottage	NN
cord-016293-pyb00pt5	445	35	cheese	cheese	NN
cord-016293-pyb00pt5	445	36	,	,	,
cord-016293-pyb00pt5	445	37	allowing	allow	VBG
cord-016293-pyb00pt5	445	38	it	-PRON-	PRP
cord-016293-pyb00pt5	445	39	to	to	TO
cord-016293-pyb00pt5	445	40	be	be	VB
cord-016293-pyb00pt5	445	41	retained	retain	VBN
cord-016293-pyb00pt5	445	42	for	for	IN
cord-016293-pyb00pt5	445	43	longer	long	JJR
cord-016293-pyb00pt5	445	44	periods	period	NNS
cord-016293-pyb00pt5	445	45	in	in	IN
cord-016293-pyb00pt5	445	46	a	a	DT
cord-016293-pyb00pt5	445	47	neonate	neonate	NN
cord-016293-pyb00pt5	445	48	's	's	POS
cord-016293-pyb00pt5	445	49	stomach	stomach	NN
cord-016293-pyb00pt5	445	50	.	.	.
cord-016293-pyb00pt5	446	1	The	the	DT
cord-016293-pyb00pt5	446	2	dairy	dairy	NN
cord-016293-pyb00pt5	446	3	industry	industry	NN
cord-016293-pyb00pt5	446	4	takes	take	VBZ
cord-016293-pyb00pt5	446	5	advantage	advantage	NN
cord-016293-pyb00pt5	446	6	of	of	IN
cord-016293-pyb00pt5	446	7	this	this	DT
cord-016293-pyb00pt5	446	8	property	property	NN
cord-016293-pyb00pt5	446	9	to	to	TO
cord-016293-pyb00pt5	446	10	conduct	conduct	VB
cord-016293-pyb00pt5	446	11	the	the	DT
cord-016293-pyb00pt5	446	12	first	first	JJ
cord-016293-pyb00pt5	446	13	step	step	NN
cord-016293-pyb00pt5	446	14	in	in	IN
cord-016293-pyb00pt5	446	15	cheese	cheese	NN
cord-016293-pyb00pt5	446	16	production	production	NN
cord-016293-pyb00pt5	446	17	.	.	.
cord-016293-pyb00pt5	447	1	Chy	Chy	NNP
cord-016293-pyb00pt5	447	2	-	-	HYPH
cord-016293-pyb00pt5	447	3	Max	Max	NNP
cord-016293-pyb00pt5	447	4	™	™	NN
cord-016293-pyb00pt5	447	5	,	,	,
cord-016293-pyb00pt5	447	6	an	an	DT
cord-016293-pyb00pt5	447	7	artificially	artificially	RB
cord-016293-pyb00pt5	447	8	produced	produce	VBN
cord-016293-pyb00pt5	447	9	form	form	NN
cord-016293-pyb00pt5	447	10	of	of	IN
cord-016293-pyb00pt5	447	11	the	the	DT
cord-016293-pyb00pt5	447	12	chymosin	chymosin	NNP
cord-016293-pyb00pt5	447	13	enzyme	enzyme	NN
cord-016293-pyb00pt5	447	14	for	for	IN
cord-016293-pyb00pt5	447	15	cheese	cheese	NN
cord-016293-pyb00pt5	447	16	-	-	HYPH
cord-016293-pyb00pt5	447	17	making	making	NN
cord-016293-pyb00pt5	447	18	,	,	,
cord-016293-pyb00pt5	447	19	was	be	VBD
cord-016293-pyb00pt5	447	20	approved	approve	VBN
cord-016293-pyb00pt5	447	21	in	in	IN
cord-016293-pyb00pt5	447	22	1990	1990	CD
cord-016293-pyb00pt5	447	23	.	.	.
cord-016293-pyb00pt5	448	1	In	in	IN
cord-016293-pyb00pt5	448	2	some	some	DT
cord-016293-pyb00pt5	448	3	instances	instance	NNS
cord-016293-pyb00pt5	448	4	they	-PRON-	PRP
cord-016293-pyb00pt5	448	5	replace	replace	VBP
cord-016293-pyb00pt5	448	6	less	less	RBR
cord-016293-pyb00pt5	448	7	acceptable	acceptable	JJ
cord-016293-pyb00pt5	448	8	"	"	``
cord-016293-pyb00pt5	448	9	older	old	JJR
cord-016293-pyb00pt5	448	10	"	"	''
cord-016293-pyb00pt5	448	11	technology	technology	NN
cord-016293-pyb00pt5	448	12	,	,	,
cord-016293-pyb00pt5	448	13	for	for	IN
cord-016293-pyb00pt5	448	14	example	example	NN
cord-016293-pyb00pt5	448	15	the	the	DT
cord-016293-pyb00pt5	448	16	enzyme	enzyme	NN
cord-016293-pyb00pt5	448	17	chymosin	chymosin	NNP
cord-016293-pyb00pt5	448	18	.	.	.
cord-016293-pyb00pt5	449	1	Unlike	unlike	IN
cord-016293-pyb00pt5	449	2	crops	crop	NNS
cord-016293-pyb00pt5	449	3	industrial	industrial	JJ
cord-016293-pyb00pt5	449	4	enzymes	enzyme	NNS
cord-016293-pyb00pt5	449	5	have	have	VBP
cord-016293-pyb00pt5	449	6	had	have	VBN
cord-016293-pyb00pt5	449	7	relatively	relatively	RB
cord-016293-pyb00pt5	449	8	easy	easy	JJ
cord-016293-pyb00pt5	449	9	passage	passage	NN
cord-016293-pyb00pt5	449	10	to	to	IN
cord-016293-pyb00pt5	449	11	acceptance	acceptance	NN
cord-016293-pyb00pt5	449	12	for	for	IN
cord-016293-pyb00pt5	449	13	a	a	DT
cord-016293-pyb00pt5	449	14	number	number	NN
cord-016293-pyb00pt5	449	15	of	of	IN
cord-016293-pyb00pt5	449	16	reasons	reason	NNS
cord-016293-pyb00pt5	449	17	.	.	.
cord-016293-pyb00pt5	450	1	As	as	IN
cord-016293-pyb00pt5	450	2	noted	note	VBN
cord-016293-pyb00pt5	450	3	they	-PRON-	PRP
cord-016293-pyb00pt5	450	4	are	be	VBP
cord-016293-pyb00pt5	450	5	part	part	NN
cord-016293-pyb00pt5	450	6	of	of	IN
cord-016293-pyb00pt5	450	7	the	the	DT
cord-016293-pyb00pt5	450	8	processing	processing	NN
cord-016293-pyb00pt5	450	9	system	system	NN
cord-016293-pyb00pt5	450	10	and	and	CC
cord-016293-pyb00pt5	450	11	theoretically	theoretically	RB
cord-016293-pyb00pt5	450	12	do	do	VBP
cord-016293-pyb00pt5	450	13	not	not	RB
cord-016293-pyb00pt5	450	14	appear	appear	VB
cord-016293-pyb00pt5	450	15	in	in	IN
cord-016293-pyb00pt5	450	16	the	the	DT
cord-016293-pyb00pt5	450	17	final	final	JJ
cord-016293-pyb00pt5	450	18	product	product	NN
cord-016293-pyb00pt5	450	19	.	.	.
cord-016293-pyb00pt5	451	1	Today	today	NN
cord-016293-pyb00pt5	451	2	about	about	IN
cord-016293-pyb00pt5	451	3	90	90	CD
cord-016293-pyb00pt5	451	4	%	%	NN
cord-016293-pyb00pt5	451	5	of	of	IN
cord-016293-pyb00pt5	451	6	the	the	DT
cord-016293-pyb00pt5	451	7	hard	hard	JJ
cord-016293-pyb00pt5	451	8	cheese	cheese	NN
cord-016293-pyb00pt5	451	9	in	in	IN
cord-016293-pyb00pt5	451	10	the	the	DT
cord-016293-pyb00pt5	451	11	US	US	NNP
cord-016293-pyb00pt5	451	12	and	and	CC
cord-016293-pyb00pt5	451	13	UK	UK	NNP
cord-016293-pyb00pt5	451	14	is	be	VBZ
cord-016293-pyb00pt5	451	15	made	make	VBN
cord-016293-pyb00pt5	451	16	using	use	VBG
cord-016293-pyb00pt5	451	17	chymosin	chymosin	NNP
cord-016293-pyb00pt5	451	18	from	from	IN
cord-016293-pyb00pt5	451	19	geneticallymodified	geneticallymodifie	VBN
cord-016293-pyb00pt5	451	20	microbes	microbe	NNS
cord-016293-pyb00pt5	451	21	.	.	.
cord-016293-pyb00pt5	452	1	It	-PRON-	PRP
cord-016293-pyb00pt5	452	2	is	be	VBZ
cord-016293-pyb00pt5	452	3	easier	easy	JJR
cord-016293-pyb00pt5	452	4	to	to	TO
cord-016293-pyb00pt5	452	5	purify	purify	VB
cord-016293-pyb00pt5	452	6	,	,	,
cord-016293-pyb00pt5	452	7	more	more	RBR
cord-016293-pyb00pt5	452	8	active	active	JJ
cord-016293-pyb00pt5	452	9	(	(	-LRB-
cord-016293-pyb00pt5	452	10	95	95	CD
cord-016293-pyb00pt5	452	11	%	%	NN
cord-016293-pyb00pt5	452	12	as	as	IN
cord-016293-pyb00pt5	452	13	compared	compare	VBN
cord-016293-pyb00pt5	452	14	to	to	IN
cord-016293-pyb00pt5	452	15	5	5	CD
cord-016293-pyb00pt5	452	16	%	%	NN
cord-016293-pyb00pt5	452	17	)	)	-RRB-
cord-016293-pyb00pt5	452	18	and	and	CC
cord-016293-pyb00pt5	452	19	less	less	RBR
cord-016293-pyb00pt5	452	20	expensive	expensive	JJ
cord-016293-pyb00pt5	452	21	to	to	TO
cord-016293-pyb00pt5	452	22	produce	produce	VB
cord-016293-pyb00pt5	453	1	(	(	-LRB-
cord-016293-pyb00pt5	453	2	Microbes	microbe	NNS
cord-016293-pyb00pt5	453	3	are	be	VBP
cord-016293-pyb00pt5	453	4	more	more	RBR
cord-016293-pyb00pt5	453	5	prolific	prolific	JJ
cord-016293-pyb00pt5	453	6	,	,	,
cord-016293-pyb00pt5	453	7	more	more	RBR
cord-016293-pyb00pt5	453	8	productive	productive	JJ
cord-016293-pyb00pt5	453	9	and	and	CC
cord-016293-pyb00pt5	453	10	cheaper	cheap	JJR
cord-016293-pyb00pt5	453	11	to	to	TO
cord-016293-pyb00pt5	453	12	keep	keep	VB
cord-016293-pyb00pt5	453	13	than	than	IN
cord-016293-pyb00pt5	453	14	calves	calf	NNS
cord-016293-pyb00pt5	453	15	)	)	-RRB-
cord-016293-pyb00pt5	453	16	.	.	.
cord-016293-pyb00pt5	454	1	Like	like	IN
cord-016293-pyb00pt5	454	2	all	all	DT
cord-016293-pyb00pt5	454	3	enzymes	enzyme	NNS
cord-016293-pyb00pt5	454	4	it	-PRON-	PRP
cord-016293-pyb00pt5	454	5	is	be	VBZ
cord-016293-pyb00pt5	454	6	required	require	VBN
cord-016293-pyb00pt5	454	7	only	only	RB
cord-016293-pyb00pt5	454	8	in	in	IN
cord-016293-pyb00pt5	454	9	very	very	RB
cord-016293-pyb00pt5	454	10	small	small	JJ
cord-016293-pyb00pt5	454	11	quantities	quantity	NNS
cord-016293-pyb00pt5	454	12	and	and	CC
cord-016293-pyb00pt5	454	13	because	because	IN
cord-016293-pyb00pt5	454	14	it	-PRON-	PRP
cord-016293-pyb00pt5	454	15	is	be	VBZ
cord-016293-pyb00pt5	454	16	a	a	DT
cord-016293-pyb00pt5	454	17	relatively	relatively	RB
cord-016293-pyb00pt5	454	18	unstable	unstable	JJ
cord-016293-pyb00pt5	454	19	protein	protein	NN
cord-016293-pyb00pt5	454	20	it	-PRON-	PRP
cord-016293-pyb00pt5	454	21	breaks	break	VBZ
cord-016293-pyb00pt5	454	22	down	down	RP
cord-016293-pyb00pt5	454	23	as	as	IN
cord-016293-pyb00pt5	454	24	the	the	DT
cord-016293-pyb00pt5	454	25	cheese	cheese	NN
cord-016293-pyb00pt5	454	26	matures	mature	VBZ
cord-016293-pyb00pt5	454	27	.	.	.
cord-016293-pyb00pt5	455	1	Indeed	indeed	RB
cord-016293-pyb00pt5	455	2	,	,	,
cord-016293-pyb00pt5	455	3	if	if	IN
cord-016293-pyb00pt5	455	4	the	the	DT
cord-016293-pyb00pt5	455	5	enzyme	enzyme	NN
cord-016293-pyb00pt5	455	6	remained	remain	VBD
cord-016293-pyb00pt5	455	7	active	active	JJ
cord-016293-pyb00pt5	455	8	for	for	IN
cord-016293-pyb00pt5	455	9	too	too	RB
cord-016293-pyb00pt5	455	10	long	long	RB
cord-016293-pyb00pt5	455	11	it	-PRON-	PRP
cord-016293-pyb00pt5	455	12	would	would	MD
cord-016293-pyb00pt5	455	13	adversely	adversely	RB
cord-016293-pyb00pt5	455	14	affect	affect	VB
cord-016293-pyb00pt5	455	15	the	the	DT
cord-016293-pyb00pt5	455	16	development	development	NN
cord-016293-pyb00pt5	455	17	of	of	IN
cord-016293-pyb00pt5	455	18	the	the	DT
cord-016293-pyb00pt5	455	19	cheese	cheese	NN
cord-016293-pyb00pt5	455	20	,	,	,
cord-016293-pyb00pt5	455	21	as	as	IN
cord-016293-pyb00pt5	455	22	it	-PRON-	PRP
cord-016293-pyb00pt5	455	23	would	would	MD
cord-016293-pyb00pt5	455	24	degrade	degrade	VB
cord-016293-pyb00pt5	455	25	the	the	DT
cord-016293-pyb00pt5	455	26	milk	milk	NN
cord-016293-pyb00pt5	455	27	proteins	protein	NNS
cord-016293-pyb00pt5	455	28	to	to	IN
cord-016293-pyb00pt5	455	29	too	too	RB
cord-016293-pyb00pt5	455	30	great	great	JJ
cord-016293-pyb00pt5	455	31	a	a	DT
cord-016293-pyb00pt5	455	32	degree	degree	NN
cord-016293-pyb00pt5	455	33	.	.	.
cord-016293-pyb00pt5	456	1	Such	such	JJ
cord-016293-pyb00pt5	456	2	enzymes	enzyme	NNS
cord-016293-pyb00pt5	456	3	have	have	VBP
cord-016293-pyb00pt5	456	4	gained	gain	VBN
cord-016293-pyb00pt5	456	5	the	the	DT
cord-016293-pyb00pt5	456	6	support	support	NN
cord-016293-pyb00pt5	456	7	of	of	IN
cord-016293-pyb00pt5	456	8	vegetarian	vegetarian	JJ
cord-016293-pyb00pt5	456	9	organizations	organization	NNS
cord-016293-pyb00pt5	456	10	and	and	CC
cord-016293-pyb00pt5	456	11	of	of	IN
cord-016293-pyb00pt5	456	12	some	some	DT
cord-016293-pyb00pt5	456	13	religious	religious	JJ
cord-016293-pyb00pt5	456	14	authorities	authority	NNS
cord-016293-pyb00pt5	456	15	.	.	.
cord-016293-pyb00pt5	457	1	For	for	IN
cord-016293-pyb00pt5	457	2	plants	plant	NNS
cord-016293-pyb00pt5	457	3	the	the	DT
cord-016293-pyb00pt5	457	4	nineties	ninety	NNS
cord-016293-pyb00pt5	457	5	was	be	VBD
cord-016293-pyb00pt5	457	6	the	the	DT
cord-016293-pyb00pt5	457	7	era	era	NN
cord-016293-pyb00pt5	457	8	of	of	IN
cord-016293-pyb00pt5	457	9	the	the	DT
cord-016293-pyb00pt5	457	10	first	first	JJ
cord-016293-pyb00pt5	457	11	widespread	widespread	JJ
cord-016293-pyb00pt5	457	12	commercialization	commercialization	NN
cord-016293-pyb00pt5	457	13	of	of	IN
cord-016293-pyb00pt5	457	14	what	what	WP
cord-016293-pyb00pt5	457	15	came	come	VBD
cord-016293-pyb00pt5	457	16	to	to	TO
cord-016293-pyb00pt5	457	17	be	be	VB
cord-016293-pyb00pt5	457	18	known	know	VBN
cord-016293-pyb00pt5	457	19	in	in	IN
cord-016293-pyb00pt5	457	20	often	often	RB
cord-016293-pyb00pt5	457	21	deprecating	deprecating	JJ
cord-016293-pyb00pt5	457	22	and	and	CC
cord-016293-pyb00pt5	457	23	literally	literally	RB
cord-016293-pyb00pt5	457	24	inaccurate	inaccurate	JJ
cord-016293-pyb00pt5	457	25	terms	term	NNS
cord-016293-pyb00pt5	457	26	as	as	IN
cord-016293-pyb00pt5	457	27	GMOs	gmo	NNS
cord-016293-pyb00pt5	457	28	(	(	-LRB-
cord-016293-pyb00pt5	457	29	Genetically	genetically	RB
cord-016293-pyb00pt5	457	30	Modified	modify	VBN
cord-016293-pyb00pt5	457	31	Organisms	organism	NNS
cord-016293-pyb00pt5	457	32	)	)	-RRB-
cord-016293-pyb00pt5	457	33	.	.	.
cord-016293-pyb00pt5	458	1	When	when	WRB
cord-016293-pyb00pt5	458	2	the	the	DT
cord-016293-pyb00pt5	458	3	nineties	ninety	NNS
cord-016293-pyb00pt5	458	4	dawned	dawn	VBD
cord-016293-pyb00pt5	458	5	dicotyledonous	dicotyledonous	JJ
cord-016293-pyb00pt5	458	6	plants	plant	NNS
cord-016293-pyb00pt5	458	7	were	be	VBD
cord-016293-pyb00pt5	458	8	relatively	relatively	RB
cord-016293-pyb00pt5	458	9	easily	easily	RB
cord-016293-pyb00pt5	458	10	transformed	transform	VBN
cord-016293-pyb00pt5	458	11	with	with	IN
cord-016293-pyb00pt5	458	12	Agrobacterium	agrobacterium	NN
cord-016293-pyb00pt5	458	13	tumefaciens	tumefacien	NNS
cord-016293-pyb00pt5	458	14	but	but	CC
cord-016293-pyb00pt5	458	15	many	many	JJ
cord-016293-pyb00pt5	458	16	economically	economically	RB
cord-016293-pyb00pt5	458	17	important	important	JJ
cord-016293-pyb00pt5	458	18	plants	plant	NNS
cord-016293-pyb00pt5	458	19	,	,	,
cord-016293-pyb00pt5	458	20	including	include	VBG
cord-016293-pyb00pt5	458	21	the	the	DT
cord-016293-pyb00pt5	458	22	cereals	cereal	NNS
cord-016293-pyb00pt5	458	23	,	,	,
cord-016293-pyb00pt5	458	24	remained	remain	VBD
cord-016293-pyb00pt5	458	25	inaccessible	inaccessible	JJ
cord-016293-pyb00pt5	458	26	for	for	IN
cord-016293-pyb00pt5	458	27	genetic	genetic	JJ
cord-016293-pyb00pt5	458	28	manipulation	manipulation	NN
cord-016293-pyb00pt5	458	29	because	because	IN
cord-016293-pyb00pt5	458	30	of	of	IN
cord-016293-pyb00pt5	458	31	lack	lack	NN
cord-016293-pyb00pt5	458	32	of	of	IN
cord-016293-pyb00pt5	458	33	effective	effective	JJ
cord-016293-pyb00pt5	458	34	transformation	transformation	NN
cord-016293-pyb00pt5	458	35	techniques	technique	NNS
cord-016293-pyb00pt5	458	36	.	.	.
cord-016293-pyb00pt5	459	1	In	in	IN
cord-016293-pyb00pt5	459	2	1990	1990	CD
cord-016293-pyb00pt5	459	3	this	this	DT
cord-016293-pyb00pt5	459	4	changed	change	VBD
cord-016293-pyb00pt5	459	5	with	with	IN
cord-016293-pyb00pt5	459	6	the	the	DT
cord-016293-pyb00pt5	459	7	technology	technology	NN
cord-016293-pyb00pt5	459	8	that	that	WDT
cord-016293-pyb00pt5	459	9	overcame	overcome	VBD
cord-016293-pyb00pt5	459	10	this	this	DT
cord-016293-pyb00pt5	459	11	limitation	limitation	NN
cord-016293-pyb00pt5	459	12	.	.	.
cord-016293-pyb00pt5	460	1	Michael	Michael	NNP
cord-016293-pyb00pt5	460	2	Fromm	Fromm	NNP
cord-016293-pyb00pt5	460	3	,	,	,
cord-016293-pyb00pt5	460	4	a	a	DT
cord-016293-pyb00pt5	460	5	molecular	molecular	JJ
cord-016293-pyb00pt5	460	6	biologist	biologist	NN
cord-016293-pyb00pt5	460	7	at	at	IN
cord-016293-pyb00pt5	460	8	the	the	DT
cord-016293-pyb00pt5	460	9	Plant	Plant	NNP
cord-016293-pyb00pt5	460	10	Gene	Gene	NNP
cord-016293-pyb00pt5	460	11	Expression	Expression	NNP
cord-016293-pyb00pt5	460	12	Center	Center	NNP
cord-016293-pyb00pt5	460	13	,	,	,
cord-016293-pyb00pt5	460	14	reported	report	VBD
cord-016293-pyb00pt5	460	15	the	the	DT
cord-016293-pyb00pt5	460	16	stable	stable	JJ
cord-016293-pyb00pt5	460	17	transformation	transformation	NN
cord-016293-pyb00pt5	460	18	of	of	IN
cord-016293-pyb00pt5	460	19	corn	corn	NN
cord-016293-pyb00pt5	460	20	using	use	VBG
cord-016293-pyb00pt5	460	21	a	a	DT
cord-016293-pyb00pt5	460	22	high	high	JJ
cord-016293-pyb00pt5	460	23	-	-	HYPH
cord-016293-pyb00pt5	460	24	speed	speed	NN
cord-016293-pyb00pt5	460	25	gene	gene	NN
cord-016293-pyb00pt5	460	26	gun	gun	NN
cord-016293-pyb00pt5	460	27	.	.	.
cord-016293-pyb00pt5	461	1	The	the	DT
cord-016293-pyb00pt5	461	2	method	method	NN
cord-016293-pyb00pt5	461	3	known	know	VBN
cord-016293-pyb00pt5	461	4	as	as	IN
cord-016293-pyb00pt5	461	5	biolistics	biolistic	NNS
cord-016293-pyb00pt5	461	6	uses	use	VBZ
cord-016293-pyb00pt5	461	7	a	a	DT
cord-016293-pyb00pt5	461	8	"	"	``
cord-016293-pyb00pt5	461	9	particle	particle	NN
cord-016293-pyb00pt5	461	10	gun	gun	NN
cord-016293-pyb00pt5	461	11	"	"	''
cord-016293-pyb00pt5	461	12	to	to	TO
cord-016293-pyb00pt5	461	13	shoot	shoot	VB
cord-016293-pyb00pt5	461	14	metal	metal	NN
cord-016293-pyb00pt5	461	15	particles	particle	NNS
cord-016293-pyb00pt5	461	16	coated	coat	VBN
cord-016293-pyb00pt5	461	17	with	with	IN
cord-016293-pyb00pt5	461	18	DNA	DNA	NNP
cord-016293-pyb00pt5	461	19	into	into	IN
cord-016293-pyb00pt5	461	20	cells	cell	NNS
cord-016293-pyb00pt5	461	21	.	.	.
cord-016293-pyb00pt5	462	1	Initially	initially	RB
cord-016293-pyb00pt5	462	2	a	a	DT
cord-016293-pyb00pt5	462	3	gunpowder	gunpowder	NN
cord-016293-pyb00pt5	462	4	charge	charge	NN
cord-016293-pyb00pt5	462	5	subsequently	subsequently	RB
cord-016293-pyb00pt5	462	6	replaced	replace	VBN
cord-016293-pyb00pt5	462	7	by	by	IN
cord-016293-pyb00pt5	462	8	helium	helium	NN
cord-016293-pyb00pt5	462	9	gas	gas	NN
cord-016293-pyb00pt5	462	10	was	be	VBD
cord-016293-pyb00pt5	462	11	used	use	VBN
cord-016293-pyb00pt5	462	12	to	to	TO
cord-016293-pyb00pt5	462	13	accelerate	accelerate	VB
cord-016293-pyb00pt5	462	14	the	the	DT
cord-016293-pyb00pt5	462	15	particles	particle	NNS
cord-016293-pyb00pt5	462	16	in	in	IN
cord-016293-pyb00pt5	462	17	the	the	DT
cord-016293-pyb00pt5	462	18	gun	gun	NN
cord-016293-pyb00pt5	462	19	.	.	.
cord-016293-pyb00pt5	463	1	There	there	EX
cord-016293-pyb00pt5	463	2	is	be	VBZ
cord-016293-pyb00pt5	463	3	a	a	DT
cord-016293-pyb00pt5	463	4	minimal	minimal	JJ
cord-016293-pyb00pt5	463	5	disruption	disruption	NN
cord-016293-pyb00pt5	463	6	of	of	IN
cord-016293-pyb00pt5	463	7	tissue	tissue	NN
cord-016293-pyb00pt5	463	8	and	and	CC
cord-016293-pyb00pt5	464	1	the	the	DT
cord-016293-pyb00pt5	464	2	success	success	NN
cord-016293-pyb00pt5	464	3	rate	rate	NN
cord-016293-pyb00pt5	464	4	has	have	VBZ
cord-016293-pyb00pt5	464	5	been	be	VBN
cord-016293-pyb00pt5	464	6	extremely	extremely	RB
cord-016293-pyb00pt5	464	7	high	high	JJ
cord-016293-pyb00pt5	464	8	for	for	IN
cord-016293-pyb00pt5	464	9	applications	application	NNS
cord-016293-pyb00pt5	464	10	in	in	IN
cord-016293-pyb00pt5	464	11	several	several	JJ
cord-016293-pyb00pt5	464	12	plant	plant	NN
cord-016293-pyb00pt5	464	13	species	specie	NNS
cord-016293-pyb00pt5	464	14	.	.	.
cord-016293-pyb00pt5	465	1	The	the	DT
cord-016293-pyb00pt5	465	2	technology	technology	NN
cord-016293-pyb00pt5	465	3	rights	right	NNS
cord-016293-pyb00pt5	465	4	are	be	VBP
cord-016293-pyb00pt5	465	5	now	now	RB
cord-016293-pyb00pt5	465	6	owned	own	VBN
cord-016293-pyb00pt5	465	7	by	by	IN
cord-016293-pyb00pt5	465	8	DuPont	DuPont	NNP
cord-016293-pyb00pt5	465	9	.	.	.
cord-016293-pyb00pt5	466	1	In	in	IN
cord-016293-pyb00pt5	466	2	1990	1990	CD
cord-016293-pyb00pt5	466	3	some	some	DT
cord-016293-pyb00pt5	466	4	of	of	IN
cord-016293-pyb00pt5	466	5	the	the	DT
cord-016293-pyb00pt5	466	6	first	first	JJ
cord-016293-pyb00pt5	466	7	of	of	IN
cord-016293-pyb00pt5	466	8	the	the	DT
cord-016293-pyb00pt5	466	9	field	field	NN
cord-016293-pyb00pt5	466	10	trials	trial	NNS
cord-016293-pyb00pt5	466	11	of	of	IN
cord-016293-pyb00pt5	466	12	the	the	DT
cord-016293-pyb00pt5	466	13	crops	crop	NNS
cord-016293-pyb00pt5	466	14	that	that	WDT
cord-016293-pyb00pt5	466	15	would	would	MD
cord-016293-pyb00pt5	466	16	dominate	dominate	VB
cord-016293-pyb00pt5	466	17	the	the	DT
cord-016293-pyb00pt5	466	18	second	second	JJ
cord-016293-pyb00pt5	466	19	half	half	NN
cord-016293-pyb00pt5	466	20	of	of	IN
cord-016293-pyb00pt5	466	21	the	the	DT
cord-016293-pyb00pt5	466	22	nineties	ninety	NNS
cord-016293-pyb00pt5	466	23	began	begin	VBD
cord-016293-pyb00pt5	466	24	,	,	,
cord-016293-pyb00pt5	466	25	including	include	VBG
cord-016293-pyb00pt5	466	26	Bt	Bt	NNP
cord-016293-pyb00pt5	466	27	corn	corn	NN
cord-016293-pyb00pt5	466	28	(	(	-LRB-
cord-016293-pyb00pt5	466	29	with	with	IN
cord-016293-pyb00pt5	466	30	the	the	DT
cord-016293-pyb00pt5	466	31	Bacillus	Bacillus	NNP
cord-016293-pyb00pt5	466	32	thuriengenesis	thuriengenesis	NN
cord-016293-pyb00pt5	466	33	Cry	Cry	NNP
cord-016293-pyb00pt5	466	34	protein	protein	NN
cord-016293-pyb00pt5	466	35	discussed	discuss	VBD
cord-016293-pyb00pt5	466	36	in	in	IN
cord-016293-pyb00pt5	466	37	chapter	chapter	NN
cord-016293-pyb00pt5	466	38	three	three	CD
cord-016293-pyb00pt5	466	39	)	)	-RRB-
cord-016293-pyb00pt5	466	40	.	.	.
cord-016293-pyb00pt5	467	1	In	in	IN
cord-016293-pyb00pt5	467	2	1992	1992	CD
cord-016293-pyb00pt5	467	3	the	the	DT
cord-016293-pyb00pt5	467	4	FDA	FDA	NNP
cord-016293-pyb00pt5	467	5	declared	declare	VBD
cord-016293-pyb00pt5	467	6	that	that	IN
cord-016293-pyb00pt5	467	7	genetically	genetically	RB
cord-016293-pyb00pt5	467	8	engineered	engineer	VBN
cord-016293-pyb00pt5	467	9	foods	food	NNS
cord-016293-pyb00pt5	467	10	are	be	VBP
cord-016293-pyb00pt5	467	11	"	"	``
cord-016293-pyb00pt5	467	12	not	not	RB
cord-016293-pyb00pt5	467	13	inherently	inherently	RB
cord-016293-pyb00pt5	467	14	dangerous	dangerous	JJ
cord-016293-pyb00pt5	467	15	"	"	''
cord-016293-pyb00pt5	467	16	and	and	CC
cord-016293-pyb00pt5	467	17	do	do	VBP
cord-016293-pyb00pt5	467	18	not	not	RB
cord-016293-pyb00pt5	467	19	require	require	VB
cord-016293-pyb00pt5	467	20	special	special	JJ
cord-016293-pyb00pt5	467	21	regulation	regulation	NN
cord-016293-pyb00pt5	467	22	.	.	.
cord-016293-pyb00pt5	468	1	Since	since	IN
cord-016293-pyb00pt5	468	2	1992	1992	CD
cord-016293-pyb00pt5	468	3	,	,	,
cord-016293-pyb00pt5	468	4	researchers	researcher	NNS
cord-016293-pyb00pt5	468	5	have	have	VBP
cord-016293-pyb00pt5	468	6	pinpointed	pinpoint	VBN
cord-016293-pyb00pt5	468	7	and	and	CC
cord-016293-pyb00pt5	468	8	cloned	clone	VBN
cord-016293-pyb00pt5	468	9	several	several	JJ
cord-016293-pyb00pt5	468	10	of	of	IN
cord-016293-pyb00pt5	468	11	the	the	DT
cord-016293-pyb00pt5	468	12	genes	gene	NNS
cord-016293-pyb00pt5	468	13	that	that	WDT
cord-016293-pyb00pt5	468	14	make	make	VBP
cord-016293-pyb00pt5	468	15	selected	select	VBN
cord-016293-pyb00pt5	468	16	plants	plant	NNS
cord-016293-pyb00pt5	468	17	resistant	resistant	JJ
cord-016293-pyb00pt5	468	18	to	to	IN
cord-016293-pyb00pt5	468	19	certain	certain	JJ
cord-016293-pyb00pt5	468	20	bacterial	bacterial	JJ
cord-016293-pyb00pt5	468	21	and	and	CC
cord-016293-pyb00pt5	468	22	fungal	fungal	JJ
cord-016293-pyb00pt5	468	23	infections	infection	NNS
cord-016293-pyb00pt5	468	24	;	;	:
cord-016293-pyb00pt5	468	25	some	some	DT
cord-016293-pyb00pt5	468	26	of	of	IN
cord-016293-pyb00pt5	468	27	these	these	DT
cord-016293-pyb00pt5	468	28	genes	gene	NNS
cord-016293-pyb00pt5	468	29	have	have	VBP
cord-016293-pyb00pt5	468	30	been	be	VBN
cord-016293-pyb00pt5	468	31	successfully	successfully	RB
cord-016293-pyb00pt5	468	32	inserted	insert	VBN
cord-016293-pyb00pt5	468	33	into	into	IN
cord-016293-pyb00pt5	468	34	crop	crop	NN
cord-016293-pyb00pt5	468	35	plants	plant	NNS
cord-016293-pyb00pt5	468	36	that	that	WDT
cord-016293-pyb00pt5	468	37	lack	lack	VBP
cord-016293-pyb00pt5	468	38	them	-PRON-	PRP
cord-016293-pyb00pt5	468	39	.	.	.
cord-016293-pyb00pt5	469	1	Many	many	JJ
cord-016293-pyb00pt5	469	2	more	more	JJR
cord-016293-pyb00pt5	469	3	infection	infection	NN
cord-016293-pyb00pt5	469	4	-	-	HYPH
cord-016293-pyb00pt5	469	5	resistant	resistant	JJ
cord-016293-pyb00pt5	469	6	crops	crop	NNS
cord-016293-pyb00pt5	469	7	are	be	VBP
cord-016293-pyb00pt5	469	8	expected	expect	VBN
cord-016293-pyb00pt5	469	9	in	in	IN
cord-016293-pyb00pt5	469	10	the	the	DT
cord-016293-pyb00pt5	469	11	near	near	JJ
cord-016293-pyb00pt5	469	12	future	future	NN
cord-016293-pyb00pt5	469	13	,	,	,
cord-016293-pyb00pt5	469	14	as	as	IN
cord-016293-pyb00pt5	469	15	scientists	scientist	NNS
cord-016293-pyb00pt5	469	16	find	find	VBP
cord-016293-pyb00pt5	469	17	more	more	JJR
cord-016293-pyb00pt5	469	18	plant	plant	NN
cord-016293-pyb00pt5	469	19	genes	gene	NNS
cord-016293-pyb00pt5	469	20	in	in	IN
cord-016293-pyb00pt5	469	21	nature	nature	NN
cord-016293-pyb00pt5	469	22	that	that	WDT
cord-016293-pyb00pt5	469	23	make	make	VBP
cord-016293-pyb00pt5	469	24	plants	plant	NNS
cord-016293-pyb00pt5	469	25	resistant	resistant	JJ
cord-016293-pyb00pt5	469	26	to	to	IN
cord-016293-pyb00pt5	469	27	pests	pest	NNS
cord-016293-pyb00pt5	469	28	.	.	.
cord-016293-pyb00pt5	470	1	Plant	plant	NN
cord-016293-pyb00pt5	470	2	genes	gene	NNS
cord-016293-pyb00pt5	470	3	,	,	,
cord-016293-pyb00pt5	470	4	however	however	RB
cord-016293-pyb00pt5	470	5	,	,	,
cord-016293-pyb00pt5	470	6	are	be	VBP
cord-016293-pyb00pt5	470	7	just	just	RB
cord-016293-pyb00pt5	470	8	a	a	DT
cord-016293-pyb00pt5	470	9	portion	portion	NN
cord-016293-pyb00pt5	470	10	of	of	IN
cord-016293-pyb00pt5	470	11	the	the	DT
cord-016293-pyb00pt5	470	12	arsenal	arsenal	NN
cord-016293-pyb00pt5	470	13	;	;	:
cord-016293-pyb00pt5	470	14	microorganisms	microorganism	NNS
cord-016293-pyb00pt5	470	15	other	other	JJ
cord-016293-pyb00pt5	470	16	than	than	IN
cord-016293-pyb00pt5	470	17	Bt	Bt	NNP
cord-016293-pyb00pt5	470	18	also	also	RB
cord-016293-pyb00pt5	470	19	are	be	VBP
cord-016293-pyb00pt5	470	20	being	be	VBG
cord-016293-pyb00pt5	470	21	mined	mine	VBN
cord-016293-pyb00pt5	470	22	for	for	IN
cord-016293-pyb00pt5	470	23	genes	gene	NNS
cord-016293-pyb00pt5	470	24	that	that	WDT
cord-016293-pyb00pt5	470	25	could	could	MD
cord-016293-pyb00pt5	470	26	help	help	VB
cord-016293-pyb00pt5	470	27	plants	plant	NNS
cord-016293-pyb00pt5	470	28	fend	fend	VB
cord-016293-pyb00pt5	470	29	off	off	RP
cord-016293-pyb00pt5	470	30	invaders	invader	NNS
cord-016293-pyb00pt5	470	31	that	that	WDT
cord-016293-pyb00pt5	470	32	cause	cause	VBP
cord-016293-pyb00pt5	470	33	crop	crop	NN
cord-016293-pyb00pt5	470	34	damage	damage	NN
cord-016293-pyb00pt5	470	35	.	.	.
cord-016293-pyb00pt5	471	1	The	the	DT
cord-016293-pyb00pt5	471	2	major	major	JJ
cord-016293-pyb00pt5	471	3	milestone	milestone	NN
cord-016293-pyb00pt5	471	4	of	of	IN
cord-016293-pyb00pt5	471	5	the	the	DT
cord-016293-pyb00pt5	471	6	decade	decade	NN
cord-016293-pyb00pt5	471	7	in	in	IN
cord-016293-pyb00pt5	471	8	crop	crop	NN
cord-016293-pyb00pt5	471	9	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	471	10	was	be	VBD
cord-016293-pyb00pt5	471	11	approval	approval	NN
cord-016293-pyb00pt5	471	12	of	of	IN
cord-016293-pyb00pt5	471	13	the	the	DT
cord-016293-pyb00pt5	471	14	first	first	JJ
cord-016293-pyb00pt5	471	15	bioengineered	bioengineered	JJ
cord-016293-pyb00pt5	471	16	crop	crop	NN
cord-016293-pyb00pt5	471	17	plant	plant	NN
cord-016293-pyb00pt5	471	18	in	in	IN
cord-016293-pyb00pt5	471	19	1994	1994	CD
cord-016293-pyb00pt5	471	20	.	.	.
cord-016293-pyb00pt5	472	1	It	-PRON-	PRP
cord-016293-pyb00pt5	472	2	represented	represent	VBD
cord-016293-pyb00pt5	472	3	a	a	DT
cord-016293-pyb00pt5	472	4	double	double	JJ
cord-016293-pyb00pt5	472	5	first	first	JJ
cord-016293-pyb00pt5	472	6	not	not	RB
cord-016293-pyb00pt5	472	7	just	just	RB
cord-016293-pyb00pt5	472	8	of	of	IN
cord-016293-pyb00pt5	472	9	the	the	DT
cord-016293-pyb00pt5	472	10	first	first	JJ
cord-016293-pyb00pt5	472	11	approved	approve	VBN
cord-016293-pyb00pt5	472	12	food	food	NN
cord-016293-pyb00pt5	472	13	crop	crop	NN
cord-016293-pyb00pt5	472	14	but	but	CC
cord-016293-pyb00pt5	472	15	also	also	RB
cord-016293-pyb00pt5	472	16	of	of	IN
cord-016293-pyb00pt5	472	17	the	the	DT
cord-016293-pyb00pt5	472	18	first	first	JJ
cord-016293-pyb00pt5	472	19	commercial	commercial	JJ
cord-016293-pyb00pt5	472	20	validation	validation	NN
cord-016293-pyb00pt5	472	21	of	of	IN
cord-016293-pyb00pt5	472	22	a	a	DT
cord-016293-pyb00pt5	472	23	technology	technology	NN
cord-016293-pyb00pt5	472	24	which	which	WDT
cord-016293-pyb00pt5	472	25	was	be	VBD
cord-016293-pyb00pt5	472	26	to	to	TO
cord-016293-pyb00pt5	472	27	be	be	VB
cord-016293-pyb00pt5	472	28	surpassed	surpass	VBN
cord-016293-pyb00pt5	472	29	later	later	RB
cord-016293-pyb00pt5	472	30	in	in	IN
cord-016293-pyb00pt5	472	31	the	the	DT
cord-016293-pyb00pt5	472	32	decade	decade	NN
cord-016293-pyb00pt5	472	33	.	.	.
cord-016293-pyb00pt5	473	1	That	that	DT
cord-016293-pyb00pt5	473	2	technology	technology	NN
cord-016293-pyb00pt5	473	3	,	,	,
cord-016293-pyb00pt5	473	4	antisense	antisense	NN
cord-016293-pyb00pt5	473	5	technology	technology	NN
cord-016293-pyb00pt5	473	6	works	work	VBZ
cord-016293-pyb00pt5	473	7	because	because	IN
cord-016293-pyb00pt5	473	8	nucleic	nucleic	JJ
cord-016293-pyb00pt5	473	9	acids	acid	NNS
cord-016293-pyb00pt5	473	10	have	have	VBP
cord-016293-pyb00pt5	473	11	a	a	DT
cord-016293-pyb00pt5	473	12	natural	natural	JJ
cord-016293-pyb00pt5	473	13	affinity	affinity	NN
cord-016293-pyb00pt5	473	14	for	for	IN
cord-016293-pyb00pt5	473	15	each	each	DT
cord-016293-pyb00pt5	473	16	other	other	JJ
cord-016293-pyb00pt5	473	17	.	.	.
cord-016293-pyb00pt5	474	1	When	when	WRB
cord-016293-pyb00pt5	474	2	a	a	DT
cord-016293-pyb00pt5	474	3	gene	gene	NN
cord-016293-pyb00pt5	474	4	coding	code	VBG
cord-016293-pyb00pt5	474	5	for	for	IN
cord-016293-pyb00pt5	474	6	the	the	DT
cord-016293-pyb00pt5	474	7	target	target	NN
cord-016293-pyb00pt5	474	8	in	in	IN
cord-016293-pyb00pt5	474	9	the	the	DT
cord-016293-pyb00pt5	474	10	genome	genome	NN
cord-016293-pyb00pt5	474	11	is	be	VBZ
cord-016293-pyb00pt5	474	12	introduced	introduce	VBN
cord-016293-pyb00pt5	474	13	in	in	IN
cord-016293-pyb00pt5	474	14	the	the	DT
cord-016293-pyb00pt5	474	15	opposite	opposite	JJ
cord-016293-pyb00pt5	474	16	orientation	orientation	NN
cord-016293-pyb00pt5	474	17	,	,	,
cord-016293-pyb00pt5	474	18	the	the	DT
cord-016293-pyb00pt5	474	19	reverse	reverse	JJ
cord-016293-pyb00pt5	474	20	RNA	RNA	NNP
cord-016293-pyb00pt5	474	21	strand	strand	NN
cord-016293-pyb00pt5	474	22	anneals	anneal	NNS
cord-016293-pyb00pt5	474	23	and	and	CC
cord-016293-pyb00pt5	474	24	effectively	effectively	RB
cord-016293-pyb00pt5	474	25	blocks	block	VBZ
cord-016293-pyb00pt5	474	26	expression	expression	NN
cord-016293-pyb00pt5	474	27	of	of	IN
cord-016293-pyb00pt5	474	28	the	the	DT
cord-016293-pyb00pt5	474	29	enzyme	enzyme	NN
cord-016293-pyb00pt5	474	30	.	.	.
cord-016293-pyb00pt5	475	1	This	this	DT
cord-016293-pyb00pt5	475	2	technology	technology	NN
cord-016293-pyb00pt5	475	3	was	be	VBD
cord-016293-pyb00pt5	475	4	patented	patent	VBN
cord-016293-pyb00pt5	475	5	by	by	IN
cord-016293-pyb00pt5	475	6	Calgene	Calgene	NNP
cord-016293-pyb00pt5	475	7	for	for	IN
cord-016293-pyb00pt5	475	8	plant	plant	NN
cord-016293-pyb00pt5	475	9	applications	application	NNS
cord-016293-pyb00pt5	475	10	and	and	CC
cord-016293-pyb00pt5	475	11	was	be	VBD
cord-016293-pyb00pt5	475	12	the	the	DT
cord-016293-pyb00pt5	475	13	technology	technology	NN
cord-016293-pyb00pt5	475	14	behind	behind	IN
cord-016293-pyb00pt5	475	15	the	the	DT
cord-016293-pyb00pt5	475	16	famous	famous	JJ
cord-016293-pyb00pt5	475	17	FLAVR	FLAVR	NNP
cord-016293-pyb00pt5	475	18	SAVR	SAVR	NNP
cord-016293-pyb00pt5	475	19	tomatoes	tomato	NNS
cord-016293-pyb00pt5	475	20	.	.	.
cord-016293-pyb00pt5	476	1	The	the	DT
cord-016293-pyb00pt5	476	2	first	first	JJ
cord-016293-pyb00pt5	476	3	success	success	NN
cord-016293-pyb00pt5	476	4	for	for	IN
cord-016293-pyb00pt5	476	5	antisense	antisense	NN
cord-016293-pyb00pt5	476	6	in	in	IN
cord-016293-pyb00pt5	476	7	medicine	medicine	NN
cord-016293-pyb00pt5	476	8	was	be	VBD
cord-016293-pyb00pt5	476	9	in	in	IN
cord-016293-pyb00pt5	476	10	1998	1998	CD
cord-016293-pyb00pt5	476	11	when	when	WRB
cord-016293-pyb00pt5	476	12	the	the	DT
cord-016293-pyb00pt5	476	13	U.S.	U.S.	NNP
cord-016293-pyb00pt5	476	14	Food	Food	NNP
cord-016293-pyb00pt5	476	15	and	and	CC
cord-016293-pyb00pt5	476	16	Drug	Drug	NNP
cord-016293-pyb00pt5	476	17	Administration	Administration	NNP
cord-016293-pyb00pt5	476	18	gave	give	VBD
cord-016293-pyb00pt5	476	19	the	the	DT
cord-016293-pyb00pt5	476	20	go	go	NN
cord-016293-pyb00pt5	476	21	-	-	HYPH
cord-016293-pyb00pt5	476	22	ahead	ahead	NN
cord-016293-pyb00pt5	476	23	to	to	IN
cord-016293-pyb00pt5	476	24	the	the	DT
cord-016293-pyb00pt5	476	25	cytomegalovirus	cytomegalovirus	NN
cord-016293-pyb00pt5	476	26	(	(	-LRB-
cord-016293-pyb00pt5	476	27	CMV	CMV	NNP
cord-016293-pyb00pt5	476	28	)	)	-RRB-
cord-016293-pyb00pt5	476	29	inhibitor	inhibitor	NNP
cord-016293-pyb00pt5	476	30	fomivirsen	fomivirsen	NNP
cord-016293-pyb00pt5	476	31	,	,	,
cord-016293-pyb00pt5	476	32	a	a	DT
cord-016293-pyb00pt5	476	33	phosphorothionate	phosphorothionate	NN
cord-016293-pyb00pt5	476	34	antiviral	antiviral	JJ
cord-016293-pyb00pt5	476	35	for	for	IN
cord-016293-pyb00pt5	476	36	the	the	DT
cord-016293-pyb00pt5	476	37	AIDS	AIDS	NNP
cord-016293-pyb00pt5	476	38	-	-	HYPH
cord-016293-pyb00pt5	476	39	related	relate	VBN
cord-016293-pyb00pt5	476	40	condition	condition	NN
cord-016293-pyb00pt5	476	41	CMV	CMV	NNP
cord-016293-pyb00pt5	476	42	retinitis	retinitis	NN
cord-016293-pyb00pt5	476	43	making	make	VBG
cord-016293-pyb00pt5	476	44	it	-PRON-	PRP
cord-016293-pyb00pt5	476	45	the	the	DT
cord-016293-pyb00pt5	476	46	first	first	JJ
cord-016293-pyb00pt5	476	47	drug	drug	NN
cord-016293-pyb00pt5	476	48	belonging	belong	VBG
cord-016293-pyb00pt5	476	49	to	to	IN
cord-016293-pyb00pt5	476	50	Isis	Isis	NNP
cord-016293-pyb00pt5	476	51	,	,	,
cord-016293-pyb00pt5	476	52	and	and	CC
cord-016293-pyb00pt5	476	53	the	the	DT
cord-016293-pyb00pt5	476	54	first	first	JJ
cord-016293-pyb00pt5	476	55	antisense	antisense	NN
cord-016293-pyb00pt5	476	56	drug	drug	NN
cord-016293-pyb00pt5	476	57	ever	ever	RB
cord-016293-pyb00pt5	476	58	,	,	,
cord-016293-pyb00pt5	476	59	to	to	TO
cord-016293-pyb00pt5	476	60	be	be	VB
cord-016293-pyb00pt5	476	61	approved	approve	VBN
cord-016293-pyb00pt5	476	62	.	.	.
cord-016293-pyb00pt5	477	1	Another	another	DT
cord-016293-pyb00pt5	477	2	technology	technology	NN
cord-016293-pyb00pt5	477	3	,	,	,
cord-016293-pyb00pt5	477	4	although	although	IN
cord-016293-pyb00pt5	477	5	not	not	RB
cord-016293-pyb00pt5	477	6	apparent	apparent	JJ
cord-016293-pyb00pt5	477	7	at	at	IN
cord-016293-pyb00pt5	477	8	the	the	DT
cord-016293-pyb00pt5	477	9	time	time	NN
cord-016293-pyb00pt5	477	10	was	be	VBD
cord-016293-pyb00pt5	477	11	behind	behind	IN
cord-016293-pyb00pt5	477	12	the	the	DT
cord-016293-pyb00pt5	477	13	second	second	JJ
cord-016293-pyb00pt5	477	14	approval	approval	NN
cord-016293-pyb00pt5	477	15	and	and	CC
cord-016293-pyb00pt5	477	16	also	also	RB
cord-016293-pyb00pt5	477	17	the	the	DT
cord-016293-pyb00pt5	477	18	first	first	JJ
cord-016293-pyb00pt5	477	19	and	and	CC
cord-016293-pyb00pt5	477	20	only	only	RB
cord-016293-pyb00pt5	477	21	successful	successful	JJ
cord-016293-pyb00pt5	477	22	to	to	IN
cord-016293-pyb00pt5	477	23	date	date	NN
cord-016293-pyb00pt5	477	24	in	in	IN
cord-016293-pyb00pt5	477	25	a	a	DT
cord-016293-pyb00pt5	477	26	commercial	commercial	JJ
cord-016293-pyb00pt5	477	27	tree	tree	NN
cord-016293-pyb00pt5	477	28	fruit	fruit	NN
cord-016293-pyb00pt5	477	29	biotech	biotech	NNP
cord-016293-pyb00pt5	477	30	application	application	NN
cord-016293-pyb00pt5	477	31	.	.	.
cord-016293-pyb00pt5	478	1	The	the	DT
cord-016293-pyb00pt5	478	2	former	former	JJ
cord-016293-pyb00pt5	478	3	was	be	VBD
cord-016293-pyb00pt5	478	4	a	a	DT
cord-016293-pyb00pt5	478	5	virus	virus	NN
cord-016293-pyb00pt5	478	6	resistant	resistant	JJ
cord-016293-pyb00pt5	478	7	squash	squash	NN
cord-016293-pyb00pt5	478	8	the	the	DT
cord-016293-pyb00pt5	478	9	second	second	JJ
cord-016293-pyb00pt5	478	10	the	the	DT
cord-016293-pyb00pt5	478	11	papaya	papaya	NN
cord-016293-pyb00pt5	478	12	ringspot	ringspot	NN
cord-016293-pyb00pt5	478	13	resistant	resistant	JJ
cord-016293-pyb00pt5	478	14	papaya	papaya	NN
cord-016293-pyb00pt5	478	15	.	.	.
cord-016293-pyb00pt5	479	1	Both	both	DT
cord-016293-pyb00pt5	479	2	owed	owe	VBD
cord-016293-pyb00pt5	479	3	their	-PRON-	PRP$
cord-016293-pyb00pt5	479	4	existence	existence	NN
cord-016293-pyb00pt5	479	5	as	as	RB
cord-016293-pyb00pt5	479	6	much	much	JJ
cord-016293-pyb00pt5	479	7	to	to	TO
cord-016293-pyb00pt5	479	8	historic	historic	JJ
cord-016293-pyb00pt5	479	9	experience	experience	NN
cord-016293-pyb00pt5	479	10	as	as	IN
cord-016293-pyb00pt5	479	11	modern	modern	JJ
cord-016293-pyb00pt5	479	12	technology	technology	NN
cord-016293-pyb00pt5	479	13	.	.	.
cord-016293-pyb00pt5	480	1	Genetically	genetically	RB
cord-016293-pyb00pt5	480	2	engineered	engineer	VBN
cord-016293-pyb00pt5	480	3	virus	virus	NN
cord-016293-pyb00pt5	480	4	-	-	HYPH
cord-016293-pyb00pt5	480	5	resistant	resistant	JJ
cord-016293-pyb00pt5	480	6	strains	strain	NNS
cord-016293-pyb00pt5	480	7	of	of	IN
cord-016293-pyb00pt5	480	8	squash	squash	NN
cord-016293-pyb00pt5	480	9	and	and	CC
cord-016293-pyb00pt5	480	10	cantaloupe	cantaloupe	NN
cord-016293-pyb00pt5	480	11	,	,	,
cord-016293-pyb00pt5	480	12	for	for	IN
cord-016293-pyb00pt5	480	13	example	example	NN
cord-016293-pyb00pt5	480	14	,	,	,
cord-016293-pyb00pt5	480	15	would	would	MD
cord-016293-pyb00pt5	480	16	never	never	RB
cord-016293-pyb00pt5	480	17	have	have	VB
cord-016293-pyb00pt5	480	18	made	make	VBN
cord-016293-pyb00pt5	480	19	it	-PRON-	PRP
cord-016293-pyb00pt5	480	20	to	to	IN
cord-016293-pyb00pt5	480	21	farmers	farmer	NNS
cord-016293-pyb00pt5	480	22	'	'	POS
cord-016293-pyb00pt5	480	23	fields	field	NNS
cord-016293-pyb00pt5	480	24	if	if	IN
cord-016293-pyb00pt5	480	25	plant	plant	NN
cord-016293-pyb00pt5	480	26	breeders	breeder	NNS
cord-016293-pyb00pt5	480	27	in	in	IN
cord-016293-pyb00pt5	480	28	the	the	DT
cord-016293-pyb00pt5	480	29	1930	1930	CD
cord-016293-pyb00pt5	480	30	's	's	POS
cord-016293-pyb00pt5	480	31	had	have	VBD
cord-016293-pyb00pt5	480	32	not	not	RB
cord-016293-pyb00pt5	480	33	noticed	notice	VBN
cord-016293-pyb00pt5	480	34	that	that	IN
cord-016293-pyb00pt5	480	35	plants	plant	NNS
cord-016293-pyb00pt5	480	36	infected	infect	VBN
cord-016293-pyb00pt5	480	37	with	with	IN
cord-016293-pyb00pt5	480	38	a	a	DT
cord-016293-pyb00pt5	480	39	mild	mild	JJ
cord-016293-pyb00pt5	480	40	strain	strain	NN
cord-016293-pyb00pt5	480	41	of	of	IN
cord-016293-pyb00pt5	480	42	a	a	DT
cord-016293-pyb00pt5	480	43	virus	virus	NN
cord-016293-pyb00pt5	480	44	do	do	VBP
cord-016293-pyb00pt5	480	45	not	not	RB
cord-016293-pyb00pt5	480	46	succumb	succumb	VB
cord-016293-pyb00pt5	480	47	to	to	IN
cord-016293-pyb00pt5	480	48	more	more	RBR
cord-016293-pyb00pt5	480	49	destructive	destructive	JJ
cord-016293-pyb00pt5	480	50	strains	strain	NNS
cord-016293-pyb00pt5	480	51	of	of	IN
cord-016293-pyb00pt5	480	52	the	the	DT
cord-016293-pyb00pt5	480	53	same	same	JJ
cord-016293-pyb00pt5	480	54	virus	virus	NN
cord-016293-pyb00pt5	480	55	.	.	.
cord-016293-pyb00pt5	481	1	That	that	DT
cord-016293-pyb00pt5	481	2	finding	finding	NN
cord-016293-pyb00pt5	481	3	led	lead	VBN
cord-016293-pyb00pt5	481	4	plant	plant	NN
cord-016293-pyb00pt5	481	5	pathologist	pathologist	NN
cord-016293-pyb00pt5	481	6	Roger	Roger	NNP
cord-016293-pyb00pt5	481	7	Beachy	Beachy	NNP
cord-016293-pyb00pt5	481	8	,	,	,
cord-016293-pyb00pt5	481	9	then	then	RB
cord-016293-pyb00pt5	481	10	at	at	IN
cord-016293-pyb00pt5	481	11	Washington	Washington	NNP
cord-016293-pyb00pt5	481	12	University	University	NNP
cord-016293-pyb00pt5	481	13	in	in	IN
cord-016293-pyb00pt5	481	14	Saint	Saint	NNP
cord-016293-pyb00pt5	481	15	Louis	Louis	NNP
cord-016293-pyb00pt5	481	16	,	,	,
cord-016293-pyb00pt5	481	17	to	to	TO
cord-016293-pyb00pt5	481	18	wonder	wonder	VB
cord-016293-pyb00pt5	481	19	exactly	exactly	RB
cord-016293-pyb00pt5	481	20	how	how	WRB
cord-016293-pyb00pt5	481	21	such	such	JJ
cord-016293-pyb00pt5	481	22	"	"	``
cord-016293-pyb00pt5	481	23	cross	cross	NN
cord-016293-pyb00pt5	481	24	-	-	NN
cord-016293-pyb00pt5	481	25	protection	protection	JJ
cord-016293-pyb00pt5	481	26	"	"	''
cord-016293-pyb00pt5	481	27	worked	work	VBD
cord-016293-pyb00pt5	481	28	-did	-did	CD
cord-016293-pyb00pt5	481	29	part	part	NN
cord-016293-pyb00pt5	481	30	of	of	IN
cord-016293-pyb00pt5	481	31	the	the	DT
cord-016293-pyb00pt5	481	32	virus	virus	NN
cord-016293-pyb00pt5	481	33	prompt	prompt	VB
cord-016293-pyb00pt5	481	34	it	-PRON-	PRP
cord-016293-pyb00pt5	481	35	?	?	.
cord-016293-pyb00pt5	482	1	In	in	IN
cord-016293-pyb00pt5	482	2	collaboration	collaboration	NN
cord-016293-pyb00pt5	482	3	with	with	IN
cord-016293-pyb00pt5	482	4	researchers	researcher	NNS
cord-016293-pyb00pt5	482	5	at	at	IN
cord-016293-pyb00pt5	482	6	Monsanto	Monsanto	NNP
cord-016293-pyb00pt5	482	7	,	,	,
cord-016293-pyb00pt5	482	8	Beachy	Beachy	NNP
cord-016293-pyb00pt5	482	9	used	use	VBD
cord-016293-pyb00pt5	482	10	an	an	DT
cord-016293-pyb00pt5	482	11	A.	a.	NN
cord-016293-pyb00pt5	482	12	tumefaciens	tumefaciens	NN
cord-016293-pyb00pt5	482	13	vector	vector	NN
cord-016293-pyb00pt5	482	14	to	to	TO
cord-016293-pyb00pt5	482	15	insert	insert	VB
cord-016293-pyb00pt5	482	16	into	into	IN
cord-016293-pyb00pt5	482	17	tomato	tomato	NN
cord-016293-pyb00pt5	482	18	plants	plant	NNS
cord-016293-pyb00pt5	482	19	a	a	DT
cord-016293-pyb00pt5	482	20	gene	gene	NN
cord-016293-pyb00pt5	482	21	that	that	WDT
cord-016293-pyb00pt5	482	22	produces	produce	VBZ
cord-016293-pyb00pt5	482	23	one	one	CD
cord-016293-pyb00pt5	482	24	of	of	IN
cord-016293-pyb00pt5	482	25	the	the	DT
cord-016293-pyb00pt5	482	26	proteins	protein	NNS
cord-016293-pyb00pt5	482	27	that	that	WDT
cord-016293-pyb00pt5	482	28	makes	make	VBZ
cord-016293-pyb00pt5	482	29	up	up	RP
cord-016293-pyb00pt5	482	30	the	the	DT
cord-016293-pyb00pt5	482	31	protein	protein	NN
cord-016293-pyb00pt5	482	32	coat	coat	NN
cord-016293-pyb00pt5	482	33	of	of	IN
cord-016293-pyb00pt5	482	34	the	the	DT
cord-016293-pyb00pt5	482	35	tobacco	tobacco	NN
cord-016293-pyb00pt5	482	36	mosaic	mosaic	NN
cord-016293-pyb00pt5	482	37	virus	virus	NN
cord-016293-pyb00pt5	482	38	.	.	.
cord-016293-pyb00pt5	483	1	He	-PRON-	PRP
cord-016293-pyb00pt5	483	2	then	then	RB
cord-016293-pyb00pt5	483	3	inoculated	inoculate	VBD
cord-016293-pyb00pt5	483	4	these	these	DT
cord-016293-pyb00pt5	483	5	plants	plant	NNS
cord-016293-pyb00pt5	483	6	with	with	IN
cord-016293-pyb00pt5	483	7	the	the	DT
cord-016293-pyb00pt5	483	8	virus	virus	NN
cord-016293-pyb00pt5	483	9	and	and	CC
cord-016293-pyb00pt5	483	10	was	be	VBD
cord-016293-pyb00pt5	483	11	pleased	pleased	JJ
cord-016293-pyb00pt5	483	12	to	to	TO
cord-016293-pyb00pt5	483	13	discover	discover	VB
cord-016293-pyb00pt5	483	14	,	,	,
cord-016293-pyb00pt5	483	15	as	as	IN
cord-016293-pyb00pt5	483	16	reported	report	VBN
cord-016293-pyb00pt5	483	17	in	in	IN
cord-016293-pyb00pt5	483	18	1986	1986	CD
cord-016293-pyb00pt5	483	19	,	,	,
cord-016293-pyb00pt5	483	20	that	that	IN
cord-016293-pyb00pt5	483	21	the	the	DT
cord-016293-pyb00pt5	483	22	vast	vast	JJ
cord-016293-pyb00pt5	483	23	majority	majority	NN
cord-016293-pyb00pt5	483	24	of	of	IN
cord-016293-pyb00pt5	483	25	plants	plant	NNS
cord-016293-pyb00pt5	483	26	did	do	VBD
cord-016293-pyb00pt5	483	27	not	not	RB
cord-016293-pyb00pt5	483	28	succumb	succumb	VB
cord-016293-pyb00pt5	483	29	to	to	IN
cord-016293-pyb00pt5	483	30	the	the	DT
cord-016293-pyb00pt5	483	31	virus	virus	NN
cord-016293-pyb00pt5	483	32	.	.	.
cord-016293-pyb00pt5	484	1	Eight	eight	CD
cord-016293-pyb00pt5	484	2	years	year	NNS
cord-016293-pyb00pt5	484	3	later	later	RB
cord-016293-pyb00pt5	484	4	,	,	,
cord-016293-pyb00pt5	484	5	in	in	IN
cord-016293-pyb00pt5	484	6	1994	1994	CD
cord-016293-pyb00pt5	484	7	,	,	,
cord-016293-pyb00pt5	484	8	virus	virus	NN
cord-016293-pyb00pt5	484	9	-	-	HYPH
cord-016293-pyb00pt5	484	10	resistant	resistant	JJ
cord-016293-pyb00pt5	484	11	squash	squash	NN
cord-016293-pyb00pt5	484	12	seeds	seed	NNS
cord-016293-pyb00pt5	484	13	created	create	VBN
cord-016293-pyb00pt5	484	14	with	with	IN
cord-016293-pyb00pt5	484	15	Beachy	Beachy	NNP
cord-016293-pyb00pt5	484	16	's	's	POS
cord-016293-pyb00pt5	484	17	method	method	NN
cord-016293-pyb00pt5	484	18	reached	reach	VBD
cord-016293-pyb00pt5	484	19	the	the	DT
cord-016293-pyb00pt5	484	20	market	market	NN
cord-016293-pyb00pt5	484	21	,	,	,
cord-016293-pyb00pt5	484	22	to	to	TO
cord-016293-pyb00pt5	484	23	be	be	VB
cord-016293-pyb00pt5	484	24	followed	follow	VBN
cord-016293-pyb00pt5	484	25	soon	soon	RB
cord-016293-pyb00pt5	484	26	by	by	IN
cord-016293-pyb00pt5	484	27	bioengineered	bioengineere	VBN
cord-016293-pyb00pt5	484	28	virus	virus	NN
cord-016293-pyb00pt5	484	29	-	-	HYPH
cord-016293-pyb00pt5	484	30	resistant	resistant	JJ
cord-016293-pyb00pt5	484	31	seeds	seed	NNS
cord-016293-pyb00pt5	484	32	for	for	IN
cord-016293-pyb00pt5	484	33	cantaloupes	cantaloupe	NNS
cord-016293-pyb00pt5	484	34	,	,	,
cord-016293-pyb00pt5	484	35	potatoes	potato	NNS
cord-016293-pyb00pt5	484	36	,	,	,
cord-016293-pyb00pt5	484	37	and	and	CC
cord-016293-pyb00pt5	484	38	papayas	papayas	NN
cord-016293-pyb00pt5	484	39	.	.	.
cord-016293-pyb00pt5	485	1	(	(	-LRB-
cord-016293-pyb00pt5	485	2	Breeders	breeder	NNS
cord-016293-pyb00pt5	485	3	had	have	VBD
cord-016293-pyb00pt5	485	4	already	already	RB
cord-016293-pyb00pt5	485	5	created	create	VBN
cord-016293-pyb00pt5	485	6	virusresistant	virusresistant	JJ
cord-016293-pyb00pt5	485	7	tomato	tomato	NN
cord-016293-pyb00pt5	485	8	seeds	seed	NNS
cord-016293-pyb00pt5	485	9	by	by	IN
cord-016293-pyb00pt5	485	10	using	use	VBG
cord-016293-pyb00pt5	485	11	traditional	traditional	JJ
cord-016293-pyb00pt5	485	12	techniques	technique	NNS
cord-016293-pyb00pt5	485	13	.	.	.
cord-016293-pyb00pt5	485	14	)	)	-RRB-
cord-016293-pyb00pt5	486	1	And	and	CC
cord-016293-pyb00pt5	486	2	the	the	DT
cord-016293-pyb00pt5	486	3	method	method	NN
cord-016293-pyb00pt5	486	4	of	of	IN
cord-016293-pyb00pt5	486	5	protection	protection	NN
cord-016293-pyb00pt5	486	6	still	still	RB
cord-016293-pyb00pt5	486	7	remained	remain	VBD
cord-016293-pyb00pt5	486	8	a	a	DT
cord-016293-pyb00pt5	486	9	mystery	mystery	NN
cord-016293-pyb00pt5	486	10	when	when	WRB
cord-016293-pyb00pt5	486	11	the	the	DT
cord-016293-pyb00pt5	486	12	first	first	JJ
cord-016293-pyb00pt5	486	13	approvals	approval	NNS
cord-016293-pyb00pt5	486	14	were	be	VBD
cord-016293-pyb00pt5	486	15	given	give	VBN
cord-016293-pyb00pt5	486	16	in	in	IN
cord-016293-pyb00pt5	486	17	1994	1994	CD
cord-016293-pyb00pt5	486	18	and	and	CC
cord-016293-pyb00pt5	486	19	1996	1996	CD
cord-016293-pyb00pt5	486	20	.	.	.
cord-016293-pyb00pt5	487	1	Gene	gene	NN
cord-016293-pyb00pt5	487	2	silencing	silencing	NN
cord-016293-pyb00pt5	487	3	was	be	VBD
cord-016293-pyb00pt5	487	4	perceived	perceive	VBN
cord-016293-pyb00pt5	487	5	initially	initially	RB
cord-016293-pyb00pt5	487	6	as	as	IN
cord-016293-pyb00pt5	487	7	an	an	DT
cord-016293-pyb00pt5	487	8	unpredictable	unpredictable	JJ
cord-016293-pyb00pt5	487	9	and	and	CC
cord-016293-pyb00pt5	487	10	inconvenient	inconvenient	JJ
cord-016293-pyb00pt5	487	11	side	side	NN
cord-016293-pyb00pt5	487	12	effect	effect	NN
cord-016293-pyb00pt5	487	13	of	of	IN
cord-016293-pyb00pt5	487	14	introducing	introduce	VBG
cord-016293-pyb00pt5	487	15	transgenes	transgene	NNS
cord-016293-pyb00pt5	487	16	into	into	IN
cord-016293-pyb00pt5	487	17	plants	plant	NNS
cord-016293-pyb00pt5	487	18	.	.	.
cord-016293-pyb00pt5	488	1	It	-PRON-	PRP
cord-016293-pyb00pt5	488	2	now	now	RB
cord-016293-pyb00pt5	488	3	seems	seem	VBZ
cord-016293-pyb00pt5	488	4	that	that	IN
cord-016293-pyb00pt5	488	5	it	-PRON-	PRP
cord-016293-pyb00pt5	488	6	is	be	VBZ
cord-016293-pyb00pt5	488	7	the	the	DT
cord-016293-pyb00pt5	488	8	consequence	consequence	NN
cord-016293-pyb00pt5	488	9	of	of	IN
cord-016293-pyb00pt5	488	10	accidentally	accidentally	RB
cord-016293-pyb00pt5	488	11	triggering	trigger	VBG
cord-016293-pyb00pt5	488	12	the	the	DT
cord-016293-pyb00pt5	488	13	plant	plant	NN
cord-016293-pyb00pt5	488	14	's	's	POS
cord-016293-pyb00pt5	488	15	adaptive	adaptive	JJ
cord-016293-pyb00pt5	488	16	defense	defense	NN
cord-016293-pyb00pt5	488	17	mechanism	mechanism	NN
cord-016293-pyb00pt5	488	18	against	against	IN
cord-016293-pyb00pt5	488	19	viruses	virus	NNS
cord-016293-pyb00pt5	488	20	and	and	CC
cord-016293-pyb00pt5	488	21	transposable	transposable	JJ
cord-016293-pyb00pt5	488	22	elements	element	NNS
cord-016293-pyb00pt5	488	23	.	.	.
cord-016293-pyb00pt5	489	1	This	this	DT
cord-016293-pyb00pt5	489	2	recently	recently	RB
cord-016293-pyb00pt5	489	3	discovered	discover	VBN
cord-016293-pyb00pt5	489	4	mechanism	mechanism	NN
cord-016293-pyb00pt5	489	5	,	,	,
cord-016293-pyb00pt5	489	6	although	although	IN
cord-016293-pyb00pt5	489	7	mechanistically	mechanistically	RB
cord-016293-pyb00pt5	489	8	different	different	JJ
cord-016293-pyb00pt5	489	9	,	,	,
cord-016293-pyb00pt5	489	10	has	have	VBZ
cord-016293-pyb00pt5	489	11	a	a	DT
cord-016293-pyb00pt5	489	12	number	number	NN
cord-016293-pyb00pt5	489	13	of	of	IN
cord-016293-pyb00pt5	489	14	parallels	parallel	NNS
cord-016293-pyb00pt5	489	15	with	with	IN
cord-016293-pyb00pt5	489	16	the	the	DT
cord-016293-pyb00pt5	489	17	immune	immune	JJ
cord-016293-pyb00pt5	489	18	system	system	NN
cord-016293-pyb00pt5	489	19	of	of	IN
cord-016293-pyb00pt5	489	20	mammals	mammal	NNS
cord-016293-pyb00pt5	489	21	.	.	.
cord-016293-pyb00pt5	490	1	How	how	WRB
cord-016293-pyb00pt5	490	2	this	this	DT
cord-016293-pyb00pt5	490	3	system	system	NN
cord-016293-pyb00pt5	490	4	worked	work	VBD
cord-016293-pyb00pt5	490	5	was	be	VBD
cord-016293-pyb00pt5	490	6	not	not	RB
cord-016293-pyb00pt5	490	7	elucidated	elucidate	VBN
cord-016293-pyb00pt5	490	8	until	until	IN
cord-016293-pyb00pt5	490	9	later	later	RB
cord-016293-pyb00pt5	490	10	in	in	IN
cord-016293-pyb00pt5	490	11	the	the	DT
cord-016293-pyb00pt5	490	12	decade	decade	NN
cord-016293-pyb00pt5	490	13	by	by	IN
cord-016293-pyb00pt5	490	14	a	a	DT
cord-016293-pyb00pt5	490	15	researcher	researcher	NN
cord-016293-pyb00pt5	490	16	who	who	WP
cord-016293-pyb00pt5	490	17	was	be	VBD
cord-016293-pyb00pt5	490	18	seeking	seek	VBG
cord-016293-pyb00pt5	490	19	a	a	DT
cord-016293-pyb00pt5	490	20	very	very	RB
cord-016293-pyb00pt5	490	21	different	different	JJ
cord-016293-pyb00pt5	490	22	holy	holy	NNP
cord-016293-pyb00pt5	490	23	grail	grail	NNP
cord-016293-pyb00pt5	490	24	-the	-the	DT
cord-016293-pyb00pt5	490	25	black	black	NNP
cord-016293-pyb00pt5	490	26	rose	rise	VBD
cord-016293-pyb00pt5	490	27	!	!	.
cord-016293-pyb00pt5	491	1	Rick	Rick	NNP
cord-016293-pyb00pt5	491	2	Jorgensen	Jorgensen	NNP
cord-016293-pyb00pt5	491	3	,	,	,
cord-016293-pyb00pt5	491	4	at	at	IN
cord-016293-pyb00pt5	491	5	that	that	DT
cord-016293-pyb00pt5	491	6	time	time	NN
cord-016293-pyb00pt5	491	7	at	at	IN
cord-016293-pyb00pt5	491	8	DNA	DNA	NNP
cord-016293-pyb00pt5	491	9	Plant	Plant	NNP
cord-016293-pyb00pt5	491	10	Technologies	Technologies	NNPS
cord-016293-pyb00pt5	491	11	in	in	IN
cord-016293-pyb00pt5	491	12	Oakland	Oakland	NNP
cord-016293-pyb00pt5	491	13	,	,	,
cord-016293-pyb00pt5	491	14	CA	CA	NNP
cord-016293-pyb00pt5	491	15	and	and	CC
cord-016293-pyb00pt5	491	16	subsequently	subsequently	RB
cord-016293-pyb00pt5	491	17	of	of	IN
cord-016293-pyb00pt5	491	18	,	,	,
cord-016293-pyb00pt5	491	19	of	of	IN
cord-016293-pyb00pt5	491	20	the	the	DT
cord-016293-pyb00pt5	491	21	University	University	NNP
cord-016293-pyb00pt5	491	22	of	of	IN
cord-016293-pyb00pt5	491	23	California	California	NNP
cord-016293-pyb00pt5	491	24	Davis	Davis	NNP
cord-016293-pyb00pt5	491	25	attempted	attempt	VBD
cord-016293-pyb00pt5	491	26	to	to	TO
cord-016293-pyb00pt5	491	27	overexpress	overexpress	VB
cord-016293-pyb00pt5	491	28	the	the	DT
cord-016293-pyb00pt5	491	29	chalcone	chalcone	NNP
cord-016293-pyb00pt5	491	30	synthase	synthase	NN
cord-016293-pyb00pt5	491	31	gene	gene	NN
cord-016293-pyb00pt5	491	32	by	by	IN
cord-016293-pyb00pt5	491	33	introducing	introduce	VBG
cord-016293-pyb00pt5	491	34	a	a	DT
cord-016293-pyb00pt5	491	35	modified	modify	VBN
cord-016293-pyb00pt5	491	36	copy	copy	NN
cord-016293-pyb00pt5	491	37	under	under	IN
cord-016293-pyb00pt5	491	38	a	a	DT
cord-016293-pyb00pt5	491	39	strong	strong	JJ
cord-016293-pyb00pt5	491	40	promoter	promoter	NN
cord-016293-pyb00pt5	491	41	.	.	.
cord-016293-pyb00pt5	492	1	Surprisingly	surprisingly	RB
cord-016293-pyb00pt5	492	2	he	-PRON-	PRP
cord-016293-pyb00pt5	492	3	obtained	obtain	VBD
cord-016293-pyb00pt5	492	4	white	white	JJ
cord-016293-pyb00pt5	492	5	flowers	flower	NNS
cord-016293-pyb00pt5	492	6	,	,	,
cord-016293-pyb00pt5	492	7	and	and	CC
cord-016293-pyb00pt5	492	8	many	many	JJ
cord-016293-pyb00pt5	492	9	strange	strange	JJ
cord-016293-pyb00pt5	492	10	variegated	variegated	JJ
cord-016293-pyb00pt5	492	11	purple	purple	NN
cord-016293-pyb00pt5	492	12	and	and	CC
cord-016293-pyb00pt5	492	13	white	white	JJ
cord-016293-pyb00pt5	492	14	variations	variation	NNS
cord-016293-pyb00pt5	492	15	in	in	IN
cord-016293-pyb00pt5	492	16	between	between	IN
cord-016293-pyb00pt5	492	17	.	.	.
cord-016293-pyb00pt5	493	1	This	this	DT
cord-016293-pyb00pt5	493	2	was	be	VBD
cord-016293-pyb00pt5	493	3	the	the	DT
cord-016293-pyb00pt5	493	4	first	first	JJ
cord-016293-pyb00pt5	493	5	demonstration	demonstration	NN
cord-016293-pyb00pt5	493	6	of	of	IN
cord-016293-pyb00pt5	493	7	what	what	WP
cord-016293-pyb00pt5	493	8	has	have	VBZ
cord-016293-pyb00pt5	493	9	come	come	VBN
cord-016293-pyb00pt5	493	10	to	to	TO
cord-016293-pyb00pt5	493	11	be	be	VB
cord-016293-pyb00pt5	493	12	known	know	VBN
cord-016293-pyb00pt5	493	13	as	as	IN
cord-016293-pyb00pt5	493	14	post	post	JJ
cord-016293-pyb00pt5	493	15	-	-	JJ
cord-016293-pyb00pt5	493	16	transcriptional	transcriptional	JJ
cord-016293-pyb00pt5	493	17	gene	gene	NN
cord-016293-pyb00pt5	493	18	silencing	silencing	NN
cord-016293-pyb00pt5	493	19	(	(	-LRB-
cord-016293-pyb00pt5	493	20	PTGS	PTGS	NNP
cord-016293-pyb00pt5	493	21	)	)	-RRB-
cord-016293-pyb00pt5	493	22	.	.	.
cord-016293-pyb00pt5	494	1	While	while	IN
cord-016293-pyb00pt5	494	2	initially	initially	RB
cord-016293-pyb00pt5	494	3	it	-PRON-	PRP
cord-016293-pyb00pt5	494	4	was	be	VBD
cord-016293-pyb00pt5	494	5	considered	consider	VBN
cord-016293-pyb00pt5	494	6	a	a	DT
cord-016293-pyb00pt5	494	7	strange	strange	JJ
cord-016293-pyb00pt5	494	8	phenomenon	phenomenon	NN
cord-016293-pyb00pt5	494	9	limited	limit	VBN
cord-016293-pyb00pt5	494	10	to	to	IN
cord-016293-pyb00pt5	494	11	petunias	petunia	NNS
cord-016293-pyb00pt5	494	12	and	and	CC
cord-016293-pyb00pt5	494	13	a	a	DT
cord-016293-pyb00pt5	494	14	few	few	JJ
cord-016293-pyb00pt5	494	15	other	other	JJ
cord-016293-pyb00pt5	494	16	plant	plant	NN
cord-016293-pyb00pt5	494	17	species	specie	NNS
cord-016293-pyb00pt5	494	18	,	,	,
cord-016293-pyb00pt5	494	19	it	-PRON-	PRP
cord-016293-pyb00pt5	494	20	is	be	VBZ
cord-016293-pyb00pt5	494	21	now	now	RB
cord-016293-pyb00pt5	494	22	one	one	CD
cord-016293-pyb00pt5	494	23	of	of	IN
cord-016293-pyb00pt5	494	24	the	the	DT
cord-016293-pyb00pt5	494	25	hottest	hot	JJS
cord-016293-pyb00pt5	494	26	topics	topic	NNS
cord-016293-pyb00pt5	494	27	in	in	IN
cord-016293-pyb00pt5	494	28	molecular	molecular	JJ
cord-016293-pyb00pt5	494	29	biology	biology	NN
cord-016293-pyb00pt5	494	30	.	.	.
cord-016293-pyb00pt5	495	1	RNA	RNA	NNP
cord-016293-pyb00pt5	495	2	interference	interference	NN
cord-016293-pyb00pt5	495	3	(	(	-LRB-
cord-016293-pyb00pt5	495	4	RNAi	RNAi	NNP
cord-016293-pyb00pt5	495	5	)	)	-RRB-
cord-016293-pyb00pt5	495	6	in	in	IN
cord-016293-pyb00pt5	495	7	animals	animal	NNS
cord-016293-pyb00pt5	495	8	and	and	CC
cord-016293-pyb00pt5	495	9	basal	basal	NN
cord-016293-pyb00pt5	495	10	eukaryotes	eukaryote	NNS
cord-016293-pyb00pt5	495	11	,	,	,
cord-016293-pyb00pt5	495	12	quelling	quell	VBG
cord-016293-pyb00pt5	495	13	in	in	IN
cord-016293-pyb00pt5	495	14	fungi	fungus	NNS
cord-016293-pyb00pt5	495	15	,	,	,
cord-016293-pyb00pt5	495	16	and	and	CC
cord-016293-pyb00pt5	495	17	PTGS	ptg	NNS
cord-016293-pyb00pt5	495	18	in	in	IN
cord-016293-pyb00pt5	495	19	plants	plant	NNS
cord-016293-pyb00pt5	495	20	are	be	VBP
cord-016293-pyb00pt5	495	21	examples	example	NNS
cord-016293-pyb00pt5	495	22	of	of	IN
cord-016293-pyb00pt5	495	23	a	a	DT
cord-016293-pyb00pt5	495	24	broad	broad	JJ
cord-016293-pyb00pt5	495	25	family	family	NN
cord-016293-pyb00pt5	495	26	of	of	IN
cord-016293-pyb00pt5	495	27	phenomena	phenomenon	NNS
cord-016293-pyb00pt5	495	28	collectively	collectively	RB
cord-016293-pyb00pt5	495	29	called	call	VBN
cord-016293-pyb00pt5	495	30	RNA	RNA	NNP
cord-016293-pyb00pt5	495	31	silencing	silence	VBG
cord-016293-pyb00pt5	495	32	(	(	-LRB-
cord-016293-pyb00pt5	495	33	Hannon	Hannon	NNP
cord-016293-pyb00pt5	495	34	2002	2002	CD
cord-016293-pyb00pt5	495	35	;	;	:
cord-016293-pyb00pt5	495	36	Plasterk	Plasterk	NNP
cord-016293-pyb00pt5	495	37	2002	2002	CD
cord-016293-pyb00pt5	495	38	)	)	-RRB-
cord-016293-pyb00pt5	495	39	.	.	.
cord-016293-pyb00pt5	496	1	In	in	IN
cord-016293-pyb00pt5	496	2	addition	addition	NN
cord-016293-pyb00pt5	496	3	to	to	IN
cord-016293-pyb00pt5	496	4	its	-PRON-	PRP$
cord-016293-pyb00pt5	496	5	occurrence	occurrence	NN
cord-016293-pyb00pt5	496	6	in	in	IN
cord-016293-pyb00pt5	496	7	these	these	DT
cord-016293-pyb00pt5	496	8	species	specie	NNS
cord-016293-pyb00pt5	496	9	it	-PRON-	PRP
cord-016293-pyb00pt5	496	10	has	have	VBZ
cord-016293-pyb00pt5	496	11	roles	role	NNS
cord-016293-pyb00pt5	496	12	in	in	IN
cord-016293-pyb00pt5	496	13	viral	viral	JJ
cord-016293-pyb00pt5	496	14	defense	defense	NN
cord-016293-pyb00pt5	496	15	(	(	-LRB-
cord-016293-pyb00pt5	496	16	as	as	IN
cord-016293-pyb00pt5	496	17	demonstrated	demonstrate	VBN
cord-016293-pyb00pt5	496	18	by	by	IN
cord-016293-pyb00pt5	496	19	Beachy	Beachy	NNP
cord-016293-pyb00pt5	496	20	)	)	-RRB-
cord-016293-pyb00pt5	496	21	and	and	CC
cord-016293-pyb00pt5	496	22	transposon	transposon	NN
cord-016293-pyb00pt5	496	23	silencing	silencing	NN
cord-016293-pyb00pt5	496	24	mechanisms	mechanism	NNS
cord-016293-pyb00pt5	496	25	among	among	IN
cord-016293-pyb00pt5	496	26	other	other	JJ
cord-016293-pyb00pt5	496	27	things	thing	NNS
cord-016293-pyb00pt5	496	28	.	.	.
cord-016293-pyb00pt5	497	1	Perhaps	perhaps	RB
cord-016293-pyb00pt5	497	2	most	most	RBS
cord-016293-pyb00pt5	497	3	exciting	exciting	JJ
cord-016293-pyb00pt5	497	4	,	,	,
cord-016293-pyb00pt5	497	5	however	however	RB
cord-016293-pyb00pt5	497	6	,	,	,
cord-016293-pyb00pt5	497	7	is	be	VBZ
cord-016293-pyb00pt5	497	8	the	the	DT
cord-016293-pyb00pt5	497	9	emerging	emerge	VBG
cord-016293-pyb00pt5	497	10	use	use	NN
cord-016293-pyb00pt5	497	11	of	of	IN
cord-016293-pyb00pt5	497	12	PTGS	ptg	NNS
cord-016293-pyb00pt5	497	13	and	and	CC
cord-016293-pyb00pt5	497	14	,	,	,
cord-016293-pyb00pt5	497	15	in	in	IN
cord-016293-pyb00pt5	497	16	particular	particular	JJ
cord-016293-pyb00pt5	497	17	,	,	,
cord-016293-pyb00pt5	497	18	RNAi	RNAi	NNP
cord-016293-pyb00pt5	497	19	-PTGS	-ptg	VBZ
cord-016293-pyb00pt5	497	20	initiated	initiate	VBN
cord-016293-pyb00pt5	497	21	by	by	IN
cord-016293-pyb00pt5	497	22	the	the	DT
cord-016293-pyb00pt5	497	23	introduction	introduction	NN
cord-016293-pyb00pt5	497	24	of	of	IN
cord-016293-pyb00pt5	497	25	double	double	RB
cord-016293-pyb00pt5	497	26	-	-	HYPH
cord-016293-pyb00pt5	497	27	stranded	strand	VBN
cord-016293-pyb00pt5	497	28	RNA	RNA	NNP
cord-016293-pyb00pt5	497	29	(	(	-LRB-
cord-016293-pyb00pt5	497	30	dsRNA	dsrna	NN
cord-016293-pyb00pt5	497	31	)	)	-RRB-
cord-016293-pyb00pt5	498	1	-as	-as	NFP
cord-016293-pyb00pt5	499	1	a	a	DT
cord-016293-pyb00pt5	499	2	tool	tool	NN
cord-016293-pyb00pt5	499	3	to	to	TO
cord-016293-pyb00pt5	499	4	knock	knock	VB
cord-016293-pyb00pt5	499	5	out	out	RP
cord-016293-pyb00pt5	499	6	expression	expression	NN
cord-016293-pyb00pt5	499	7	of	of	IN
cord-016293-pyb00pt5	499	8	specific	specific	JJ
cord-016293-pyb00pt5	499	9	genes	gene	NNS
cord-016293-pyb00pt5	499	10	in	in	IN
cord-016293-pyb00pt5	499	11	a	a	DT
cord-016293-pyb00pt5	499	12	variety	variety	NN
cord-016293-pyb00pt5	499	13	of	of	IN
cord-016293-pyb00pt5	499	14	organisms	organism	NNS
cord-016293-pyb00pt5	499	15	.	.	.
cord-016293-pyb00pt5	500	1	Nineteen	nineteen	CD
cord-016293-pyb00pt5	500	2	ninety	ninety	CD
cord-016293-pyb00pt5	500	3	one	one	CD
cord-016293-pyb00pt5	500	4	also	also	RB
cord-016293-pyb00pt5	500	5	heralded	herald	VBD
cord-016293-pyb00pt5	500	6	yet	yet	RB
cord-016293-pyb00pt5	500	7	another	another	DT
cord-016293-pyb00pt5	500	8	first	first	JJ
cord-016293-pyb00pt5	500	9	.	.	.
cord-016293-pyb00pt5	501	1	The	the	DT
cord-016293-pyb00pt5	501	2	February	February	NNP
cord-016293-pyb00pt5	501	3	1	1	CD
cord-016293-pyb00pt5	501	4	,	,	,
cord-016293-pyb00pt5	501	5	1991	1991	CD
cord-016293-pyb00pt5	501	6	issue	issue	NN
cord-016293-pyb00pt5	501	7	of	of	IN
cord-016293-pyb00pt5	501	8	Science	Science	NNP
cord-016293-pyb00pt5	501	9	reported	report	VBD
cord-016293-pyb00pt5	501	10	the	the	DT
cord-016293-pyb00pt5	501	11	patenting	patenting	NN
cord-016293-pyb00pt5	501	12	of	of	IN
cord-016293-pyb00pt5	501	13	"	"	``
cord-016293-pyb00pt5	501	14	molecular	molecular	JJ
cord-016293-pyb00pt5	501	15	scissors	scissor	NNS
cord-016293-pyb00pt5	501	16	"	"	''
cord-016293-pyb00pt5	501	17	:	:	:
cord-016293-pyb00pt5	501	18	the	the	DT
cord-016293-pyb00pt5	501	19	Nobel	Nobel	NNP
cord-016293-pyb00pt5	501	20	-	-	HYPH
cord-016293-pyb00pt5	501	21	prize	prize	NNP
cord-016293-pyb00pt5	501	22	winning	winning	NN
cord-016293-pyb00pt5	501	23	discovery	discovery	NN
cord-016293-pyb00pt5	501	24	of	of	IN
cord-016293-pyb00pt5	501	25	enzymatic	enzymatic	JJ
cord-016293-pyb00pt5	501	26	RNA	RNA	NNP
cord-016293-pyb00pt5	501	27	,	,	,
cord-016293-pyb00pt5	501	28	or	or	CC
cord-016293-pyb00pt5	501	29	"	"	``
cord-016293-pyb00pt5	501	30	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	501	31	,	,	,
cord-016293-pyb00pt5	501	32	"	"	''
cord-016293-pyb00pt5	501	33	by	by	IN
cord-016293-pyb00pt5	501	34	Thomas	Thomas	NNP
cord-016293-pyb00pt5	501	35	Czech	Czech	NNP
cord-016293-pyb00pt5	501	36	of	of	IN
cord-016293-pyb00pt5	501	37	the	the	DT
cord-016293-pyb00pt5	501	38	University	University	NNP
cord-016293-pyb00pt5	501	39	of	of	IN
cord-016293-pyb00pt5	501	40	Colorado	Colorado	NNP
cord-016293-pyb00pt5	501	41	.	.	.
cord-016293-pyb00pt5	502	1	It	-PRON-	PRP
cord-016293-pyb00pt5	502	2	was	be	VBD
cord-016293-pyb00pt5	502	3	noted	note	VBN
cord-016293-pyb00pt5	502	4	that	that	IN
cord-016293-pyb00pt5	502	5	the	the	DT
cord-016293-pyb00pt5	502	6	U.S.	U.S.	NNP
cord-016293-pyb00pt5	502	7	Patent	Patent	NNP
cord-016293-pyb00pt5	502	8	and	and	CC
cord-016293-pyb00pt5	502	9	Trademark	Trademark	NNP
cord-016293-pyb00pt5	502	10	Office	Office	NNP
cord-016293-pyb00pt5	502	11	had	have	VBD
cord-016293-pyb00pt5	502	12	awarded	award	VBN
cord-016293-pyb00pt5	502	13	an	an	DT
cord-016293-pyb00pt5	502	14	"	"	``
cord-016293-pyb00pt5	502	15	unusually	unusually	RB
cord-016293-pyb00pt5	502	16	broad	broad	JJ
cord-016293-pyb00pt5	502	17	"	"	''
cord-016293-pyb00pt5	502	18	patent	patent	NN
cord-016293-pyb00pt5	502	19	for	for	IN
cord-016293-pyb00pt5	502	20	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	502	21	.	.	.
cord-016293-pyb00pt5	503	1	The	the	DT
cord-016293-pyb00pt5	503	2	patent	patent	NN
cord-016293-pyb00pt5	503	3	is	be	VBZ
cord-016293-pyb00pt5	504	1	U.S.	U.S.	NNP
cord-016293-pyb00pt5	504	2	Patent	Patent	NNP
cord-016293-pyb00pt5	504	3	No	No	NNP
cord-016293-pyb00pt5	504	4	.	.	NN
cord-016293-pyb00pt5	504	5	4,987,071	4,987,071	CD
cord-016293-pyb00pt5	504	6	,	,	,
cord-016293-pyb00pt5	504	7	claim	claim	NN
cord-016293-pyb00pt5	504	8	1	1	CD
cord-016293-pyb00pt5	504	9	of	of	IN
cord-016293-pyb00pt5	504	10	which	which	WDT
cord-016293-pyb00pt5	504	11	reads	read	VBZ
cord-016293-pyb00pt5	504	12	as	as	IN
cord-016293-pyb00pt5	504	13	follows	follow	VBZ
cord-016293-pyb00pt5	504	14	:	:	:
cord-016293-pyb00pt5	504	15	"	"	``
cord-016293-pyb00pt5	504	16	An	an	DT
cord-016293-pyb00pt5	504	17	enzymatic	enzymatic	JJ
cord-016293-pyb00pt5	504	18	RNA	RNA	NNP
cord-016293-pyb00pt5	504	19	molecule	molecule	NN
cord-016293-pyb00pt5	504	20	not	not	RB
cord-016293-pyb00pt5	504	21	naturally	naturally	RB
cord-016293-pyb00pt5	504	22	occurring	occur	VBG
cord-016293-pyb00pt5	504	23	in	in	IN
cord-016293-pyb00pt5	504	24	nature	nature	NN
cord-016293-pyb00pt5	504	25	having	have	VBG
cord-016293-pyb00pt5	504	26	an	an	DT
cord-016293-pyb00pt5	504	27	endonuclease	endonuclease	NN
cord-016293-pyb00pt5	504	28	activity	activity	NN
cord-016293-pyb00pt5	504	29	independent	independent	JJ
cord-016293-pyb00pt5	504	30	of	of	IN
cord-016293-pyb00pt5	504	31	any	any	DT
cord-016293-pyb00pt5	504	32	protein	protein	NN
cord-016293-pyb00pt5	504	33	,	,	,
cord-016293-pyb00pt5	504	34	said	say	VBD
cord-016293-pyb00pt5	504	35	endonuclease	endonuclease	NN
cord-016293-pyb00pt5	504	36	activity	activity	NN
cord-016293-pyb00pt5	504	37	being	be	VBG
cord-016293-pyb00pt5	504	38	specific	specific	JJ
cord-016293-pyb00pt5	504	39	for	for	IN
cord-016293-pyb00pt5	504	40	a	a	DT
cord-016293-pyb00pt5	504	41	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	504	42	sequence	sequence	NN
cord-016293-pyb00pt5	504	43	defining	define	VBG
cord-016293-pyb00pt5	504	44	a	a	DT
cord-016293-pyb00pt5	504	45	cleavage	cleavage	NN
cord-016293-pyb00pt5	504	46	site	site	NN
cord-016293-pyb00pt5	504	47	comprising	comprise	VBG
cord-016293-pyb00pt5	504	48	single	single	RB
cord-016293-pyb00pt5	504	49	-	-	HYPH
cord-016293-pyb00pt5	504	50	stranded	strand	VBN
cord-016293-pyb00pt5	504	51	RNA	RNA	NNP
cord-016293-pyb00pt5	504	52	in	in	IN
cord-016293-pyb00pt5	504	53	a	a	DT
cord-016293-pyb00pt5	504	54	separate	separate	JJ
cord-016293-pyb00pt5	504	55	RNA	rna	NN
cord-016293-pyb00pt5	504	56	molecule	molecule	NN
cord-016293-pyb00pt5	504	57	,	,	,
cord-016293-pyb00pt5	504	58	and	and	CC
cord-016293-pyb00pt5	504	59	causing	cause	VBG
cord-016293-pyb00pt5	504	60	cleavage	cleavage	NN
cord-016293-pyb00pt5	504	61	at	at	IN
cord-016293-pyb00pt5	504	62	said	say	VBD
cord-016293-pyb00pt5	504	63	cleavage	cleavage	NN
cord-016293-pyb00pt5	504	64	site	site	NN
cord-016293-pyb00pt5	504	65	by	by	IN
cord-016293-pyb00pt5	504	66	a	a	DT
cord-016293-pyb00pt5	504	67	transesterification	transesterification	NN
cord-016293-pyb00pt5	504	68	reaction	reaction	NN
cord-016293-pyb00pt5	504	69	.	.	.
cord-016293-pyb00pt5	504	70	"	"	''
cord-016293-pyb00pt5	505	1	Although	although	IN
cord-016293-pyb00pt5	505	2	enzymes	enzyme	NNS
cord-016293-pyb00pt5	505	3	made	make	VBN
cord-016293-pyb00pt5	505	4	of	of	IN
cord-016293-pyb00pt5	505	5	protein	protein	NN
cord-016293-pyb00pt5	505	6	are	be	VBP
cord-016293-pyb00pt5	505	7	the	the	DT
cord-016293-pyb00pt5	505	8	dominant	dominant	JJ
cord-016293-pyb00pt5	505	9	form	form	NN
cord-016293-pyb00pt5	505	10	of	of	IN
cord-016293-pyb00pt5	505	11	biocatalyst	biocatalyst	NN
cord-016293-pyb00pt5	505	12	in	in	IN
cord-016293-pyb00pt5	505	13	modern	modern	JJ
cord-016293-pyb00pt5	505	14	cells	cell	NNS
cord-016293-pyb00pt5	505	15	,	,	,
cord-016293-pyb00pt5	505	16	there	there	EX
cord-016293-pyb00pt5	505	17	are	be	VBP
cord-016293-pyb00pt5	505	18	at	at	RB
cord-016293-pyb00pt5	505	19	least	least	RBS
cord-016293-pyb00pt5	505	20	eight	eight	CD
cord-016293-pyb00pt5	505	21	natural	natural	JJ
cord-016293-pyb00pt5	505	22	RNA	RNA	NNP
cord-016293-pyb00pt5	505	23	enzymes	enzyme	NNS
cord-016293-pyb00pt5	505	24	,	,	,
cord-016293-pyb00pt5	505	25	or	or	CC
cord-016293-pyb00pt5	505	26	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	505	27	,	,	,
cord-016293-pyb00pt5	505	28	that	that	WDT
cord-016293-pyb00pt5	505	29	catalyze	catalyze	VBP
cord-016293-pyb00pt5	505	30	fundamental	fundamental	JJ
cord-016293-pyb00pt5	505	31	biological	biological	JJ
cord-016293-pyb00pt5	505	32	processes	process	NNS
cord-016293-pyb00pt5	505	33	.	.	.
cord-016293-pyb00pt5	506	1	One	one	CD
cord-016293-pyb00pt5	506	2	of	of	IN
cord-016293-pyb00pt5	506	3	which	which	WDT
cord-016293-pyb00pt5	506	4	was	be	VBD
cord-016293-pyb00pt5	506	5	yet	yet	RB
cord-016293-pyb00pt5	506	6	another	another	DT
cord-016293-pyb00pt5	506	7	discovery	discovery	NN
cord-016293-pyb00pt5	506	8	by	by	IN
cord-016293-pyb00pt5	506	9	plant	plant	NN
cord-016293-pyb00pt5	506	10	virologists	virologist	NNS
cord-016293-pyb00pt5	506	11	,	,	,
cord-016293-pyb00pt5	506	12	in	in	IN
cord-016293-pyb00pt5	506	13	this	this	DT
cord-016293-pyb00pt5	506	14	instance	instance	NN
cord-016293-pyb00pt5	506	15	the	the	DT
cord-016293-pyb00pt5	506	16	hairpin	hairpin	NN
cord-016293-pyb00pt5	506	17	ribozyme	ribozyme	NNS
cord-016293-pyb00pt5	506	18	was	be	VBD
cord-016293-pyb00pt5	506	19	discovered	discover	VBN
cord-016293-pyb00pt5	506	20	by	by	IN
cord-016293-pyb00pt5	506	21	George	George	NNP
cord-016293-pyb00pt5	506	22	Bruening	Bruening	NNP
cord-016293-pyb00pt5	506	23	at	at	IN
cord-016293-pyb00pt5	506	24	UC	UC	NNP
cord-016293-pyb00pt5	506	25	Davis	Davis	NNP
cord-016293-pyb00pt5	506	26	.	.	.
cord-016293-pyb00pt5	507	1	The	the	DT
cord-016293-pyb00pt5	507	2	self	self	NN
cord-016293-pyb00pt5	507	3	-	-	HYPH
cord-016293-pyb00pt5	507	4	cleavage	cleavage	NN
cord-016293-pyb00pt5	507	5	structure	structure	NN
cord-016293-pyb00pt5	507	6	was	be	VBD
cord-016293-pyb00pt5	507	7	originally	originally	RB
cord-016293-pyb00pt5	507	8	called	call	VBN
cord-016293-pyb00pt5	507	9	a	a	DT
cord-016293-pyb00pt5	507	10	paperclip	paperclip	NN
cord-016293-pyb00pt5	507	11	,	,	,
cord-016293-pyb00pt5	507	12	by	by	IN
cord-016293-pyb00pt5	507	13	the	the	DT
cord-016293-pyb00pt5	507	14	Bruening	Bruening	NNP
cord-016293-pyb00pt5	507	15	laboratory	laboratory	NN
cord-016293-pyb00pt5	507	16	which	which	WDT
cord-016293-pyb00pt5	507	17	discovered	discover	VBD
cord-016293-pyb00pt5	507	18	the	the	DT
cord-016293-pyb00pt5	507	19	reactions	reaction	NNS
cord-016293-pyb00pt5	507	20	.	.	.
cord-016293-pyb00pt5	508	1	As	as	IN
cord-016293-pyb00pt5	508	2	mentioned	mention	VBN
cord-016293-pyb00pt5	508	3	in	in	IN
cord-016293-pyb00pt5	508	4	chapter	chapter	NN
cord-016293-pyb00pt5	508	5	3	3	CD
cord-016293-pyb00pt5	508	6	,	,	,
cord-016293-pyb00pt5	508	7	it	-PRON-	PRP
cord-016293-pyb00pt5	508	8	is	be	VBZ
cord-016293-pyb00pt5	508	9	believed	believe	VBN
cord-016293-pyb00pt5	508	10	that	that	IN
cord-016293-pyb00pt5	508	11	these	these	DT
cord-016293-pyb00pt5	508	12	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	508	13	might	may	MD
cord-016293-pyb00pt5	508	14	be	be	VB
cord-016293-pyb00pt5	508	15	the	the	DT
cord-016293-pyb00pt5	508	16	remnants	remnant	NNS
cord-016293-pyb00pt5	508	17	of	of	IN
cord-016293-pyb00pt5	508	18	an	an	DT
cord-016293-pyb00pt5	508	19	ancient	ancient	JJ
cord-016293-pyb00pt5	508	20	form	form	NN
cord-016293-pyb00pt5	508	21	of	of	IN
cord-016293-pyb00pt5	508	22	life	life	NN
cord-016293-pyb00pt5	508	23	that	that	WDT
cord-016293-pyb00pt5	508	24	was	be	VBD
cord-016293-pyb00pt5	508	25	guided	guide	VBN
cord-016293-pyb00pt5	508	26	entirely	entirely	RB
cord-016293-pyb00pt5	508	27	by	by	IN
cord-016293-pyb00pt5	508	28	RNA	RNA	NNP
cord-016293-pyb00pt5	508	29	.	.	.
cord-016293-pyb00pt5	509	1	Since	since	IN
cord-016293-pyb00pt5	509	2	a	a	DT
cord-016293-pyb00pt5	509	3	ribozyme	ribozyme	NN
cord-016293-pyb00pt5	509	4	is	be	VBZ
cord-016293-pyb00pt5	509	5	a	a	DT
cord-016293-pyb00pt5	509	6	catalytic	catalytic	JJ
cord-016293-pyb00pt5	509	7	RNA	RNA	NNP
cord-016293-pyb00pt5	509	8	molecule	molecule	NN
cord-016293-pyb00pt5	509	9	capable	capable	JJ
cord-016293-pyb00pt5	509	10	of	of	IN
cord-016293-pyb00pt5	509	11	cleaving	cleave	VBG
cord-016293-pyb00pt5	509	12	itself	-PRON-	PRP
cord-016293-pyb00pt5	509	13	and	and	CC
cord-016293-pyb00pt5	510	1	other	other	JJ
cord-016293-pyb00pt5	510	2	target	target	NN
cord-016293-pyb00pt5	510	3	RNAs	rna	NNS
cord-016293-pyb00pt5	511	1	it	-PRON-	PRP
cord-016293-pyb00pt5	511	2	therefore	therefore	RB
cord-016293-pyb00pt5	511	3	can	can	MD
cord-016293-pyb00pt5	511	4	be	be	VB
cord-016293-pyb00pt5	511	5	useful	useful	JJ
cord-016293-pyb00pt5	511	6	as	as	IN
cord-016293-pyb00pt5	511	7	a	a	DT
cord-016293-pyb00pt5	511	8	control	control	NN
cord-016293-pyb00pt5	511	9	system	system	NN
cord-016293-pyb00pt5	511	10	for	for	IN
cord-016293-pyb00pt5	511	11	turning	turn	VBG
cord-016293-pyb00pt5	511	12	off	off	RP
cord-016293-pyb00pt5	511	13	genes	gene	NNS
cord-016293-pyb00pt5	511	14	or	or	CC
cord-016293-pyb00pt5	511	15	targeting	target	VBG
cord-016293-pyb00pt5	511	16	viruses	virus	NNS
cord-016293-pyb00pt5	511	17	.	.	.
cord-016293-pyb00pt5	512	1	The	the	DT
cord-016293-pyb00pt5	512	2	possibility	possibility	NN
cord-016293-pyb00pt5	512	3	of	of	IN
cord-016293-pyb00pt5	512	4	designing	design	VBG
cord-016293-pyb00pt5	512	5	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	512	6	to	to	TO
cord-016293-pyb00pt5	512	7	cleave	cleave	VB
cord-016293-pyb00pt5	512	8	any	any	DT
cord-016293-pyb00pt5	512	9	specific	specific	JJ
cord-016293-pyb00pt5	512	10	target	target	NN
cord-016293-pyb00pt5	512	11	RNA	RNA	NNP
cord-016293-pyb00pt5	512	12	has	have	VBZ
cord-016293-pyb00pt5	512	13	rendered	render	VBN
cord-016293-pyb00pt5	512	14	them	-PRON-	PRP
cord-016293-pyb00pt5	512	15	valuable	valuable	JJ
cord-016293-pyb00pt5	512	16	tools	tool	NNS
cord-016293-pyb00pt5	512	17	in	in	IN
cord-016293-pyb00pt5	512	18	both	both	CC
cord-016293-pyb00pt5	512	19	basic	basic	JJ
cord-016293-pyb00pt5	512	20	research	research	NN
cord-016293-pyb00pt5	512	21	and	and	CC
cord-016293-pyb00pt5	512	22	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	512	23	applications	application	NNS
cord-016293-pyb00pt5	512	24	.	.	.
cord-016293-pyb00pt5	513	1	In	in	IN
cord-016293-pyb00pt5	513	2	the	the	DT
cord-016293-pyb00pt5	513	3	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	513	4	area	area	NN
cord-016293-pyb00pt5	513	5	,	,	,
cord-016293-pyb00pt5	513	6	they	-PRON-	PRP
cord-016293-pyb00pt5	513	7	have	have	VBP
cord-016293-pyb00pt5	513	8	been	be	VBN
cord-016293-pyb00pt5	513	9	exploited	exploit	VBN
cord-016293-pyb00pt5	513	10	to	to	TO
cord-016293-pyb00pt5	513	11	target	target	VB
cord-016293-pyb00pt5	513	12	viral	viral	JJ
cord-016293-pyb00pt5	513	13	RNAs	rna	NNS
cord-016293-pyb00pt5	513	14	in	in	IN
cord-016293-pyb00pt5	513	15	infectious	infectious	JJ
cord-016293-pyb00pt5	513	16	diseases	disease	NNS
cord-016293-pyb00pt5	513	17	,	,	,
cord-016293-pyb00pt5	513	18	dominant	dominant	JJ
cord-016293-pyb00pt5	513	19	oncogenes	oncogene	NNS
cord-016293-pyb00pt5	513	20	in	in	IN
cord-016293-pyb00pt5	513	21	cancers	cancer	NNS
cord-016293-pyb00pt5	513	22	and	and	CC
cord-016293-pyb00pt5	513	23	specific	specific	JJ
cord-016293-pyb00pt5	513	24	somatic	somatic	JJ
cord-016293-pyb00pt5	513	25	mutations	mutation	NNS
cord-016293-pyb00pt5	513	26	in	in	IN
cord-016293-pyb00pt5	513	27	genetic	genetic	JJ
cord-016293-pyb00pt5	513	28	disorders	disorder	NNS
cord-016293-pyb00pt5	513	29	.	.	.
cord-016293-pyb00pt5	514	1	Most	most	RBS
cord-016293-pyb00pt5	514	2	notably	notably	RB
cord-016293-pyb00pt5	514	3	,	,	,
cord-016293-pyb00pt5	514	4	several	several	JJ
cord-016293-pyb00pt5	514	5	ribozyme	ribozyme	NN
cord-016293-pyb00pt5	514	6	gene	gene	NN
cord-016293-pyb00pt5	514	7	therapy	therapy	NN
cord-016293-pyb00pt5	514	8	protocols	protocol	NNS
cord-016293-pyb00pt5	514	9	for	for	IN
cord-016293-pyb00pt5	514	10	HIV	HIV	NNP
cord-016293-pyb00pt5	514	11	patients	patient	NNS
cord-016293-pyb00pt5	514	12	are	be	VBP
cord-016293-pyb00pt5	514	13	already	already	RB
cord-016293-pyb00pt5	514	14	in	in	IN
cord-016293-pyb00pt5	514	15	Phase	phase	NN
cord-016293-pyb00pt5	514	16	1	1	CD
cord-016293-pyb00pt5	514	17	trials	trial	NNS
cord-016293-pyb00pt5	514	18	.	.	.
cord-016293-pyb00pt5	515	1	More	more	RBR
cord-016293-pyb00pt5	515	2	recently	recently	RB
cord-016293-pyb00pt5	515	3	,	,	,
cord-016293-pyb00pt5	515	4	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	515	5	have	have	VBP
cord-016293-pyb00pt5	515	6	been	be	VBN
cord-016293-pyb00pt5	515	7	used	use	VBN
cord-016293-pyb00pt5	515	8	for	for	IN
cord-016293-pyb00pt5	515	9	transgenic	transgenic	JJ
cord-016293-pyb00pt5	515	10	animal	animal	NN
cord-016293-pyb00pt5	515	11	research	research	NN
cord-016293-pyb00pt5	515	12	,	,	,
cord-016293-pyb00pt5	515	13	gene	gene	NN
cord-016293-pyb00pt5	515	14	target	target	NN
cord-016293-pyb00pt5	515	15	validation	validation	NN
cord-016293-pyb00pt5	515	16	and	and	CC
cord-016293-pyb00pt5	515	17	pathway	pathway	NN
cord-016293-pyb00pt5	515	18	elucidation	elucidation	NN
cord-016293-pyb00pt5	515	19	.	.	.
cord-016293-pyb00pt5	516	1	However	however	RB
cord-016293-pyb00pt5	516	2	,	,	,
cord-016293-pyb00pt5	516	3	targeting	target	VBG
cord-016293-pyb00pt5	516	4	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	516	5	to	to	IN
cord-016293-pyb00pt5	516	6	the	the	DT
cord-016293-pyb00pt5	516	7	cellular	cellular	JJ
cord-016293-pyb00pt5	516	8	compartment	compartment	NN
cord-016293-pyb00pt5	516	9	containing	contain	VBG
cord-016293-pyb00pt5	516	10	their	-PRON-	PRP$
cord-016293-pyb00pt5	516	11	target	target	NN
cord-016293-pyb00pt5	516	12	RNAs	rna	NNS
cord-016293-pyb00pt5	516	13	has	have	VBZ
cord-016293-pyb00pt5	516	14	proved	prove	VBN
cord-016293-pyb00pt5	516	15	a	a	DT
cord-016293-pyb00pt5	516	16	challenge	challenge	NN
cord-016293-pyb00pt5	516	17	.	.	.
cord-016293-pyb00pt5	517	1	At	at	IN
cord-016293-pyb00pt5	517	2	the	the	DT
cord-016293-pyb00pt5	517	3	other	other	JJ
cord-016293-pyb00pt5	517	4	bookend	bookend	NN
cord-016293-pyb00pt5	517	5	of	of	IN
cord-016293-pyb00pt5	517	6	the	the	DT
cord-016293-pyb00pt5	517	7	decade	decade	NN
cord-016293-pyb00pt5	517	8	in	in	IN
cord-016293-pyb00pt5	517	9	2000	2000	CD
cord-016293-pyb00pt5	517	10	,	,	,
cord-016293-pyb00pt5	517	11	Samarsky	Samarsky	NNP
cord-016293-pyb00pt5	517	12	et	et	NNP
cord-016293-pyb00pt5	517	13	al	al	NNP
cord-016293-pyb00pt5	517	14	.	.	NNP
cord-016293-pyb00pt5	517	15	reported	report	VBD
cord-016293-pyb00pt5	517	16	that	that	IN
cord-016293-pyb00pt5	517	17	a	a	DT
cord-016293-pyb00pt5	517	18	family	family	NN
cord-016293-pyb00pt5	517	19	of	of	IN
cord-016293-pyb00pt5	517	20	small	small	JJ
cord-016293-pyb00pt5	517	21	RNAs	rna	NNS
cord-016293-pyb00pt5	517	22	in	in	IN
cord-016293-pyb00pt5	517	23	the	the	DT
cord-016293-pyb00pt5	517	24	nucleolus	nucleolus	NN
cord-016293-pyb00pt5	517	25	(	(	-LRB-
cord-016293-pyb00pt5	517	26	snoRNAs	snornas	NN
cord-016293-pyb00pt5	517	27	)	)	-RRB-
cord-016293-pyb00pt5	517	28	can	can	MD
cord-016293-pyb00pt5	517	29	readily	readily	RB
cord-016293-pyb00pt5	517	30	transport	transport	VB
cord-016293-pyb00pt5	517	31	ribozymes	ribozyme	NNS
cord-016293-pyb00pt5	517	32	into	into	IN
cord-016293-pyb00pt5	517	33	this	this	DT
cord-016293-pyb00pt5	517	34	subcellular	subcellular	JJ
cord-016293-pyb00pt5	517	35	organelle	organelle	NN
cord-016293-pyb00pt5	517	36	.	.	.
cord-016293-pyb00pt5	518	1	In	in	IN
cord-016293-pyb00pt5	518	2	addition	addition	NN
cord-016293-pyb00pt5	518	3	to	to	IN
cord-016293-pyb00pt5	518	4	the	the	DT
cord-016293-pyb00pt5	518	5	already	already	RB
cord-016293-pyb00pt5	518	6	extensive	extensive	JJ
cord-016293-pyb00pt5	518	7	panoply	panoply	NN
cord-016293-pyb00pt5	518	8	of	of	IN
cord-016293-pyb00pt5	518	9	RNA	RNA	NNP
cord-016293-pyb00pt5	518	10	entities	entity	NNS
cord-016293-pyb00pt5	518	11	yet	yet	RB
cord-016293-pyb00pt5	518	12	another	another	DT
cord-016293-pyb00pt5	518	13	has	have	VBZ
cord-016293-pyb00pt5	518	14	potential	potential	NN
cord-016293-pyb00pt5	518	15	for	for	IN
cord-016293-pyb00pt5	518	16	mischief	mischief	NN
cord-016293-pyb00pt5	518	17	.	.	.
cord-016293-pyb00pt5	519	1	Viroids	Viroids	NNP
cord-016293-pyb00pt5	519	2	are	be	VBP
cord-016293-pyb00pt5	519	3	small	small	JJ
cord-016293-pyb00pt5	519	4	,	,	,
cord-016293-pyb00pt5	519	5	single	single	JJ
cord-016293-pyb00pt5	519	6	-	-	HYPH
cord-016293-pyb00pt5	519	7	stranded	stranded	JJ
cord-016293-pyb00pt5	519	8	,	,	,
cord-016293-pyb00pt5	519	9	circular	circular	JJ
cord-016293-pyb00pt5	519	10	RNAs	rna	NNS
cord-016293-pyb00pt5	519	11	containing	contain	VBG
cord-016293-pyb00pt5	519	12	246	246	CD
cord-016293-pyb00pt5	519	13	-	-	SYM
cord-016293-pyb00pt5	519	14	463	463	CD
cord-016293-pyb00pt5	519	15	nucleotides	nucleotide	NNS
cord-016293-pyb00pt5	519	16	arranged	arrange	VBN
cord-016293-pyb00pt5	519	17	in	in	IN
cord-016293-pyb00pt5	519	18	a	a	DT
cord-016293-pyb00pt5	519	19	rod	rod	NN
cord-016293-pyb00pt5	519	20	-	-	HYPH
cord-016293-pyb00pt5	519	21	like	like	JJ
cord-016293-pyb00pt5	519	22	secondary	secondary	JJ
cord-016293-pyb00pt5	519	23	structure	structure	NN
cord-016293-pyb00pt5	519	24	and	and	CC
cord-016293-pyb00pt5	519	25	are	be	VBP
cord-016293-pyb00pt5	519	26	the	the	DT
cord-016293-pyb00pt5	519	27	smallest	small	JJS
cord-016293-pyb00pt5	519	28	pathogenic	pathogenic	JJ
cord-016293-pyb00pt5	519	29	agents	agent	NNS
cord-016293-pyb00pt5	519	30	yet	yet	RB
cord-016293-pyb00pt5	519	31	described	describe	VBN
cord-016293-pyb00pt5	519	32	.	.	.
cord-016293-pyb00pt5	520	1	The	the	DT
cord-016293-pyb00pt5	520	2	smallest	small	JJS
cord-016293-pyb00pt5	520	3	viroid	viroid	NN
cord-016293-pyb00pt5	520	4	characterized	characterize	VBN
cord-016293-pyb00pt5	520	5	to	to	IN
cord-016293-pyb00pt5	520	6	date	date	NN
cord-016293-pyb00pt5	520	7	is	be	VBZ
cord-016293-pyb00pt5	520	8	rice	rice	NN
cord-016293-pyb00pt5	520	9	yellow	yellow	JJ
cord-016293-pyb00pt5	520	10	mottle	mottle	NN
cord-016293-pyb00pt5	520	11	sobemovirus	sobemovirus	NNP
cord-016293-pyb00pt5	520	12	(	(	-LRB-
cord-016293-pyb00pt5	520	13	RYMV	RYMV	NNP
cord-016293-pyb00pt5	520	14	)	)	-RRB-
cord-016293-pyb00pt5	520	15	,	,	,
cord-016293-pyb00pt5	520	16	at	at	IN
cord-016293-pyb00pt5	520	17	220	220	CD
cord-016293-pyb00pt5	520	18	nucleotides	nucleotide	NNS
cord-016293-pyb00pt5	520	19	.	.	.
cord-016293-pyb00pt5	521	1	In	in	IN
cord-016293-pyb00pt5	521	2	comparison	comparison	NN
cord-016293-pyb00pt5	521	3	,	,	,
cord-016293-pyb00pt5	521	4	the	the	DT
cord-016293-pyb00pt5	521	5	genome	genome	NN
cord-016293-pyb00pt5	521	6	of	of	IN
cord-016293-pyb00pt5	521	7	the	the	DT
cord-016293-pyb00pt5	521	8	smallest	small	JJS
cord-016293-pyb00pt5	521	9	known	know	VBN
cord-016293-pyb00pt5	521	10	viruses	virus	NNS
cord-016293-pyb00pt5	521	11	capable	capable	JJ
cord-016293-pyb00pt5	521	12	of	of	IN
cord-016293-pyb00pt5	521	13	causing	cause	VBG
cord-016293-pyb00pt5	521	14	an	an	DT
cord-016293-pyb00pt5	521	15	infection	infection	NN
cord-016293-pyb00pt5	521	16	by	by	IN
cord-016293-pyb00pt5	521	17	themselves	-PRON-	PRP
cord-016293-pyb00pt5	521	18	,	,	,
cord-016293-pyb00pt5	521	19	the	the	DT
cord-016293-pyb00pt5	521	20	single	single	RB
cord-016293-pyb00pt5	521	21	-	-	HYPH
cord-016293-pyb00pt5	521	22	stranded	strand	VBN
cord-016293-pyb00pt5	521	23	circular	circular	JJ
cord-016293-pyb00pt5	521	24	DNA	dna	NN
cord-016293-pyb00pt5	521	25	of	of	IN
cord-016293-pyb00pt5	521	26	circoviruses	circoviruse	NNS
cord-016293-pyb00pt5	521	27	,	,	,
cord-016293-pyb00pt5	521	28	is	be	VBZ
cord-016293-pyb00pt5	521	29	around	around	RB
cord-016293-pyb00pt5	521	30	2	2	CD
cord-016293-pyb00pt5	521	31	kilobases	kilobase	NNS
cord-016293-pyb00pt5	521	32	in	in	IN
cord-016293-pyb00pt5	521	33	size	size	NN
cord-016293-pyb00pt5	521	34	.	.	.
cord-016293-pyb00pt5	522	1	The	the	DT
cord-016293-pyb00pt5	522	2	first	first	JJ
cord-016293-pyb00pt5	522	3	viroid	viroid	NN
cord-016293-pyb00pt5	522	4	to	to	TO
cord-016293-pyb00pt5	522	5	be	be	VB
cord-016293-pyb00pt5	522	6	identified	identify	VBN
cord-016293-pyb00pt5	522	7	was	be	VBD
cord-016293-pyb00pt5	522	8	the	the	DT
cord-016293-pyb00pt5	522	9	Potato	Potato	NNP
cord-016293-pyb00pt5	522	10	spindle	spindle	NN
cord-016293-pyb00pt5	522	11	tuber	tuber	NN
cord-016293-pyb00pt5	522	12	viroid	viroid	NN
cord-016293-pyb00pt5	522	13	(	(	-LRB-
cord-016293-pyb00pt5	522	14	PSTVd	PSTVd	NNP
cord-016293-pyb00pt5	522	15	)	)	-RRB-
cord-016293-pyb00pt5	522	16	.	.	.
cord-016293-pyb00pt5	523	1	Some	some	DT
cord-016293-pyb00pt5	523	2	33	33	CD
cord-016293-pyb00pt5	523	3	species	specie	NNS
cord-016293-pyb00pt5	523	4	have	have	VBP
cord-016293-pyb00pt5	523	5	been	be	VBN
cord-016293-pyb00pt5	523	6	identified	identify	VBN
cord-016293-pyb00pt5	523	7	to	to	IN
cord-016293-pyb00pt5	523	8	date	date	NN
cord-016293-pyb00pt5	523	9	.	.	.
cord-016293-pyb00pt5	524	1	Unlike	unlike	IN
cord-016293-pyb00pt5	524	2	the	the	DT
cord-016293-pyb00pt5	524	3	many	many	JJ
cord-016293-pyb00pt5	524	4	satellite	satellite	NN
cord-016293-pyb00pt5	524	5	or	or	CC
cord-016293-pyb00pt5	524	6	defective	defective	JJ
cord-016293-pyb00pt5	524	7	interfering	interfere	VBG
cord-016293-pyb00pt5	524	8	RNAs	rna	NNS
cord-016293-pyb00pt5	524	9	associated	associate	VBN
cord-016293-pyb00pt5	524	10	with	with	IN
cord-016293-pyb00pt5	524	11	plant	plant	NN
cord-016293-pyb00pt5	524	12	viruses	virus	NNS
cord-016293-pyb00pt5	524	13	,	,	,
cord-016293-pyb00pt5	524	14	viroids	viroid	NNS
cord-016293-pyb00pt5	524	15	replicate	replicate	VBP
cord-016293-pyb00pt5	524	16	autonomously	autonomously	RB
cord-016293-pyb00pt5	524	17	on	on	IN
cord-016293-pyb00pt5	524	18	inoculation	inoculation	NN
cord-016293-pyb00pt5	524	19	of	of	IN
cord-016293-pyb00pt5	524	20	a	a	DT
cord-016293-pyb00pt5	524	21	susceptible	susceptible	JJ
cord-016293-pyb00pt5	524	22	host	host	NN
cord-016293-pyb00pt5	524	23	.	.	.
cord-016293-pyb00pt5	525	1	The	the	DT
cord-016293-pyb00pt5	525	2	absence	absence	NN
cord-016293-pyb00pt5	525	3	of	of	IN
cord-016293-pyb00pt5	525	4	a	a	DT
cord-016293-pyb00pt5	525	5	protein	protein	NN
cord-016293-pyb00pt5	525	6	capsid	capsid	NN
cord-016293-pyb00pt5	525	7	and	and	CC
cord-016293-pyb00pt5	525	8	of	of	IN
cord-016293-pyb00pt5	525	9	detectable	detectable	JJ
cord-016293-pyb00pt5	525	10	messenger	messenger	NN
cord-016293-pyb00pt5	525	11	RNA	RNA	NNP
cord-016293-pyb00pt5	525	12	activity	activity	NN
cord-016293-pyb00pt5	525	13	implies	imply	VBZ
cord-016293-pyb00pt5	525	14	that	that	IN
cord-016293-pyb00pt5	525	15	the	the	DT
cord-016293-pyb00pt5	525	16	information	information	NN
cord-016293-pyb00pt5	525	17	necessary	necessary	JJ
cord-016293-pyb00pt5	525	18	for	for	IN
cord-016293-pyb00pt5	525	19	replication	replication	NN
cord-016293-pyb00pt5	525	20	and	and	CC
cord-016293-pyb00pt5	525	21	pathogenesis	pathogenesis	NN
cord-016293-pyb00pt5	525	22	resides	reside	VBZ
cord-016293-pyb00pt5	525	23	within	within	IN
cord-016293-pyb00pt5	525	24	the	the	DT
cord-016293-pyb00pt5	525	25	unusual	unusual	JJ
cord-016293-pyb00pt5	525	26	structure	structure	NN
cord-016293-pyb00pt5	525	27	of	of	IN
cord-016293-pyb00pt5	525	28	the	the	DT
cord-016293-pyb00pt5	525	29	viroid	viroid	NNP
cord-016293-pyb00pt5	525	30	genome	genome	NN
cord-016293-pyb00pt5	525	31	.	.	.
cord-016293-pyb00pt5	526	1	The	the	DT
cord-016293-pyb00pt5	526	2	replication	replication	NN
cord-016293-pyb00pt5	526	3	mechanism	mechanism	NN
cord-016293-pyb00pt5	526	4	actually	actually	RB
cord-016293-pyb00pt5	526	5	involves	involve	VBZ
cord-016293-pyb00pt5	526	6	interaction	interaction	NN
cord-016293-pyb00pt5	526	7	with	with	IN
cord-016293-pyb00pt5	526	8	RNA	RNA	NNP
cord-016293-pyb00pt5	526	9	polymerase	polymerase	NN
cord-016293-pyb00pt5	526	10	II	II	NNP
cord-016293-pyb00pt5	526	11	,	,	,
cord-016293-pyb00pt5	526	12	an	an	DT
cord-016293-pyb00pt5	526	13	enzyme	enzyme	NN
cord-016293-pyb00pt5	526	14	normally	normally	RB
cord-016293-pyb00pt5	526	15	associated	associate	VBN
cord-016293-pyb00pt5	526	16	with	with	IN
cord-016293-pyb00pt5	526	17	synthesis	synthesis	NN
cord-016293-pyb00pt5	526	18	of	of	IN
cord-016293-pyb00pt5	526	19	messenger	messenger	NNP
cord-016293-pyb00pt5	526	20	RNA	RNA	NNP
cord-016293-pyb00pt5	526	21	,	,	,
cord-016293-pyb00pt5	526	22	and	and	CC
cord-016293-pyb00pt5	526	23	"	"	``
cord-016293-pyb00pt5	526	24	rolling	rolling	JJ
cord-016293-pyb00pt5	526	25	circle	circle	NN
cord-016293-pyb00pt5	526	26	"	"	''
cord-016293-pyb00pt5	526	27	synthesis	synthesis	NN
cord-016293-pyb00pt5	526	28	of	of	IN
cord-016293-pyb00pt5	526	29	new	new	NNP
cord-016293-pyb00pt5	526	30	RNA	RNA	NNP
cord-016293-pyb00pt5	526	31	.	.	.
cord-016293-pyb00pt5	527	1	Some	some	DT
cord-016293-pyb00pt5	527	2	viroids	viroid	NNS
cord-016293-pyb00pt5	527	3	have	have	VBP
cord-016293-pyb00pt5	527	4	ribozyme	ribozyme	NN
cord-016293-pyb00pt5	527	5	activity	activity	NN
cord-016293-pyb00pt5	527	6	which	which	WDT
cord-016293-pyb00pt5	527	7	allow	allow	VBP
cord-016293-pyb00pt5	527	8	self	self	NN
cord-016293-pyb00pt5	527	9	-	-	HYPH
cord-016293-pyb00pt5	527	10	cleavage	cleavage	NN
cord-016293-pyb00pt5	527	11	and	and	CC
cord-016293-pyb00pt5	527	12	ligation	ligation	NN
cord-016293-pyb00pt5	527	13	of	of	IN
cord-016293-pyb00pt5	527	14	unit	unit	NN
cord-016293-pyb00pt5	527	15	-	-	HYPH
cord-016293-pyb00pt5	527	16	size	size	NN
cord-016293-pyb00pt5	527	17	genomes	genome	NNS
cord-016293-pyb00pt5	527	18	from	from	IN
cord-016293-pyb00pt5	527	19	larger	large	JJR
cord-016293-pyb00pt5	527	20	replication	replication	NN
cord-016293-pyb00pt5	527	21	intermediates	intermediate	NNS
cord-016293-pyb00pt5	527	22	.	.	.
cord-016293-pyb00pt5	528	1	It	-PRON-	PRP
cord-016293-pyb00pt5	528	2	has	have	VBZ
cord-016293-pyb00pt5	528	3	been	be	VBN
cord-016293-pyb00pt5	528	4	proposed	propose	VBN
cord-016293-pyb00pt5	528	5	that	that	IN
cord-016293-pyb00pt5	528	6	viroids	viroid	NNS
cord-016293-pyb00pt5	528	7	are	be	VBP
cord-016293-pyb00pt5	528	8	"	"	``
cord-016293-pyb00pt5	528	9	escaped	escape	VBN
cord-016293-pyb00pt5	528	10	introns	intron	NNS
cord-016293-pyb00pt5	528	11	"	"	''
cord-016293-pyb00pt5	528	12	.	.	.
cord-016293-pyb00pt5	529	1	Viroids	Viroids	NNP
cord-016293-pyb00pt5	529	2	are	be	VBP
cord-016293-pyb00pt5	529	3	usually	usually	RB
cord-016293-pyb00pt5	529	4	transmitted	transmit	VBN
cord-016293-pyb00pt5	529	5	by	by	IN
cord-016293-pyb00pt5	529	6	seed	seed	NN
cord-016293-pyb00pt5	529	7	or	or	CC
cord-016293-pyb00pt5	529	8	pollen	pollen	NN
cord-016293-pyb00pt5	529	9	.	.	.
cord-016293-pyb00pt5	530	1	Infected	infected	JJ
cord-016293-pyb00pt5	530	2	plants	plant	NNS
cord-016293-pyb00pt5	530	3	can	can	MD
cord-016293-pyb00pt5	530	4	show	show	VB
cord-016293-pyb00pt5	530	5	distorted	distorted	JJ
cord-016293-pyb00pt5	530	6	growth	growth	NN
cord-016293-pyb00pt5	530	7	.	.	.
cord-016293-pyb00pt5	531	1	From	from	IN
cord-016293-pyb00pt5	531	2	its	-PRON-	PRP$
cord-016293-pyb00pt5	531	3	earliest	early	JJS
cord-016293-pyb00pt5	531	4	years	year	NNS
cord-016293-pyb00pt5	531	5	,	,	,
cord-016293-pyb00pt5	531	6	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	531	7	attracted	attract	VBD
cord-016293-pyb00pt5	531	8	interest	interest	NN
cord-016293-pyb00pt5	531	9	outside	outside	IN
cord-016293-pyb00pt5	531	10	scientific	scientific	JJ
cord-016293-pyb00pt5	531	11	circles	circle	NNS
cord-016293-pyb00pt5	531	12	.	.	.
cord-016293-pyb00pt5	532	1	Initially	initially	RB
cord-016293-pyb00pt5	532	2	the	the	DT
cord-016293-pyb00pt5	532	3	main	main	JJ
cord-016293-pyb00pt5	532	4	focus	focus	NN
cord-016293-pyb00pt5	532	5	of	of	IN
cord-016293-pyb00pt5	532	6	public	public	JJ
cord-016293-pyb00pt5	532	7	interest	interest	NN
cord-016293-pyb00pt5	532	8	was	be	VBD
cord-016293-pyb00pt5	532	9	on	on	IN
cord-016293-pyb00pt5	532	10	the	the	DT
cord-016293-pyb00pt5	532	11	safety	safety	NN
cord-016293-pyb00pt5	532	12	of	of	IN
cord-016293-pyb00pt5	532	13	recombinant	recombinant	JJ
cord-016293-pyb00pt5	532	14	DNA	dna	NN
cord-016293-pyb00pt5	532	15	technology	technology	NN
cord-016293-pyb00pt5	532	16	,	,	,
cord-016293-pyb00pt5	532	17	and	and	CC
cord-016293-pyb00pt5	532	18	of	of	IN
cord-016293-pyb00pt5	532	19	the	the	DT
cord-016293-pyb00pt5	532	20	possible	possible	JJ
cord-016293-pyb00pt5	532	21	risks	risk	NNS
cord-016293-pyb00pt5	532	22	of	of	IN
cord-016293-pyb00pt5	532	23	creating	create	VBG
cord-016293-pyb00pt5	532	24	uncontrollable	uncontrollable	JJ
cord-016293-pyb00pt5	532	25	and	and	CC
cord-016293-pyb00pt5	532	26	harmful	harmful	JJ
cord-016293-pyb00pt5	532	27	novel	novel	JJ
cord-016293-pyb00pt5	532	28	organisms	organism	NNS
cord-016293-pyb00pt5	532	29	(	(	-LRB-
cord-016293-pyb00pt5	532	30	Berg	Berg	NNP
cord-016293-pyb00pt5	532	31	,	,	,
cord-016293-pyb00pt5	532	32	1975	1975	CD
cord-016293-pyb00pt5	532	33	)	)	-RRB-
cord-016293-pyb00pt5	532	34	.	.	.
cord-016293-pyb00pt5	533	1	The	the	DT
cord-016293-pyb00pt5	533	2	debate	debate	NN
cord-016293-pyb00pt5	533	3	on	on	IN
cord-016293-pyb00pt5	533	4	the	the	DT
cord-016293-pyb00pt5	533	5	deliberate	deliberate	JJ
cord-016293-pyb00pt5	533	6	release	release	NN
cord-016293-pyb00pt5	533	7	of	of	IN
cord-016293-pyb00pt5	533	8	genetically	genetically	RB
cord-016293-pyb00pt5	533	9	modified	modify	VBN
cord-016293-pyb00pt5	533	10	organisms	organism	NNS
cord-016293-pyb00pt5	533	11	,	,	,
cord-016293-pyb00pt5	533	12	and	and	CC
cord-016293-pyb00pt5	533	13	on	on	IN
cord-016293-pyb00pt5	533	14	consumer	consumer	NN
cord-016293-pyb00pt5	533	15	products	product	NNS
cord-016293-pyb00pt5	533	16	containing	contain	VBG
cord-016293-pyb00pt5	533	17	or	or	CC
cord-016293-pyb00pt5	533	18	comprising	comprise	VBG
cord-016293-pyb00pt5	533	19	them	-PRON-	PRP
cord-016293-pyb00pt5	533	20	,	,	,
cord-016293-pyb00pt5	533	21	followed	follow	VBD
cord-016293-pyb00pt5	533	22	some	some	DT
cord-016293-pyb00pt5	533	23	years	year	NNS
cord-016293-pyb00pt5	533	24	later	later	RB
cord-016293-pyb00pt5	533	25	(	(	-LRB-
cord-016293-pyb00pt5	533	26	NAS	NAS	NNP
cord-016293-pyb00pt5	533	27	,	,	,
cord-016293-pyb00pt5	533	28	1987	1987	CD
cord-016293-pyb00pt5	533	29	)	)	-RRB-
cord-016293-pyb00pt5	533	30	.	.	.
cord-016293-pyb00pt5	534	1	It	-PRON-	PRP
cord-016293-pyb00pt5	534	2	is	be	VBZ
cord-016293-pyb00pt5	534	3	interesting	interesting	JJ
cord-016293-pyb00pt5	534	4	to	to	TO
cord-016293-pyb00pt5	534	5	note	note	VB
cord-016293-pyb00pt5	534	6	that	that	IN
cord-016293-pyb00pt5	534	7	within	within	IN
cord-016293-pyb00pt5	534	8	the	the	DT
cord-016293-pyb00pt5	534	9	broad	broad	JJ
cord-016293-pyb00pt5	534	10	ethical	ethical	JJ
cord-016293-pyb00pt5	534	11	tableau	tableau	NN
cord-016293-pyb00pt5	534	12	of	of	IN
cord-016293-pyb00pt5	534	13	potential	potential	JJ
cord-016293-pyb00pt5	534	14	issues	issue	NNS
cord-016293-pyb00pt5	534	15	within	within	IN
cord-016293-pyb00pt5	534	16	the	the	DT
cord-016293-pyb00pt5	534	17	science	science	NN
cord-016293-pyb00pt5	534	18	and	and	CC
cord-016293-pyb00pt5	534	19	products	product	NNS
cord-016293-pyb00pt5	534	20	of	of	IN
cord-016293-pyb00pt5	534	21	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	534	22	,	,	,
cord-016293-pyb00pt5	534	23	the	the	DT
cord-016293-pyb00pt5	534	24	seemingly	seemingly	RB
cord-016293-pyb00pt5	534	25	innocuous	innocuous	JJ
cord-016293-pyb00pt5	534	26	field	field	NN
cord-016293-pyb00pt5	534	27	of	of	IN
cord-016293-pyb00pt5	534	28	plant	plant	NN
cord-016293-pyb00pt5	534	29	modification	modification	NN
cord-016293-pyb00pt5	534	30	has	have	VBZ
cord-016293-pyb00pt5	534	31	been	be	VBN
cord-016293-pyb00pt5	534	32	one	one	CD
cord-016293-pyb00pt5	534	33	of	of	IN
cord-016293-pyb00pt5	534	34	the	the	DT
cord-016293-pyb00pt5	534	35	major	major	JJ
cord-016293-pyb00pt5	534	36	players	player	NNS
cord-016293-pyb00pt5	534	37	of	of	IN
cord-016293-pyb00pt5	534	38	the	the	DT
cord-016293-pyb00pt5	534	39	1990	1990	CD
cord-016293-pyb00pt5	534	40	's	's	POS
cord-016293-pyb00pt5	534	41	.	.	.
cord-016293-pyb00pt5	535	1	The	the	DT
cord-016293-pyb00pt5	535	2	success	success	NN
cord-016293-pyb00pt5	535	3	of	of	IN
cord-016293-pyb00pt5	535	4	agricultural	agricultural	JJ
cord-016293-pyb00pt5	535	5	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	535	6	is	be	VBZ
cord-016293-pyb00pt5	535	7	heavily	heavily	RB
cord-016293-pyb00pt5	535	8	dependent	dependent	JJ
cord-016293-pyb00pt5	535	9	on	on	IN
cord-016293-pyb00pt5	535	10	its	-PRON-	PRP$
cord-016293-pyb00pt5	535	11	acceptance	acceptance	NN
cord-016293-pyb00pt5	535	12	by	by	IN
cord-016293-pyb00pt5	535	13	the	the	DT
cord-016293-pyb00pt5	535	14	public	public	NN
cord-016293-pyb00pt5	535	15	,	,	,
cord-016293-pyb00pt5	535	16	and	and	CC
cord-016293-pyb00pt5	535	17	the	the	DT
cord-016293-pyb00pt5	535	18	regulatory	regulatory	JJ
cord-016293-pyb00pt5	535	19	framework	framework	NN
cord-016293-pyb00pt5	535	20	in	in	IN
cord-016293-pyb00pt5	535	21	which	which	WDT
cord-016293-pyb00pt5	535	22	the	the	DT
cord-016293-pyb00pt5	535	23	industry	industry	NN
cord-016293-pyb00pt5	535	24	operates	operate	VBZ
cord-016293-pyb00pt5	535	25	is	be	VBZ
cord-016293-pyb00pt5	535	26	also	also	RB
cord-016293-pyb00pt5	535	27	influenced	influence	VBN
cord-016293-pyb00pt5	535	28	by	by	IN
cord-016293-pyb00pt5	535	29	public	public	JJ
cord-016293-pyb00pt5	535	30	opinion	opinion	NN
cord-016293-pyb00pt5	535	31	.	.	.
cord-016293-pyb00pt5	536	1	As	as	IN
cord-016293-pyb00pt5	536	2	the	the	DT
cord-016293-pyb00pt5	536	3	focus	focus	NN
cord-016293-pyb00pt5	536	4	for	for	IN
cord-016293-pyb00pt5	536	5	molecular	molecular	JJ
cord-016293-pyb00pt5	536	6	biology	biology	NN
cord-016293-pyb00pt5	536	7	research	research	NN
cord-016293-pyb00pt5	536	8	shifted	shift	VBD
cord-016293-pyb00pt5	536	9	from	from	IN
cord-016293-pyb00pt5	536	10	the	the	DT
cord-016293-pyb00pt5	536	11	basic	basic	JJ
cord-016293-pyb00pt5	536	12	pursuit	pursuit	NN
cord-016293-pyb00pt5	536	13	of	of	IN
cord-016293-pyb00pt5	536	14	knowledge	knowledge	NN
cord-016293-pyb00pt5	536	15	to	to	IN
cord-016293-pyb00pt5	536	16	the	the	DT
cord-016293-pyb00pt5	536	17	pursuit	pursuit	NN
cord-016293-pyb00pt5	536	18	of	of	IN
cord-016293-pyb00pt5	536	19	lucrative	lucrative	JJ
cord-016293-pyb00pt5	536	20	applications	application	NNS
cord-016293-pyb00pt5	536	21	,	,	,
cord-016293-pyb00pt5	536	22	once	once	RB
cord-016293-pyb00pt5	536	23	again	again	RB
cord-016293-pyb00pt5	536	24	as	as	IN
cord-016293-pyb00pt5	536	25	in	in	IN
cord-016293-pyb00pt5	536	26	the	the	DT
cord-016293-pyb00pt5	536	27	previous	previous	JJ
cord-016293-pyb00pt5	536	28	two	two	CD
cord-016293-pyb00pt5	536	29	decades	decade	NNS
cord-016293-pyb00pt5	536	30	the	the	DT
cord-016293-pyb00pt5	536	31	specter	specter	NN
cord-016293-pyb00pt5	536	32	of	of	IN
cord-016293-pyb00pt5	536	33	risk	risk	NN
cord-016293-pyb00pt5	536	34	arose	arise	VBD
cord-016293-pyb00pt5	536	35	as	as	IN
cord-016293-pyb00pt5	536	36	the	the	DT
cord-016293-pyb00pt5	536	37	potential	potential	NN
cord-016293-pyb00pt5	536	38	of	of	IN
cord-016293-pyb00pt5	536	39	new	new	JJ
cord-016293-pyb00pt5	536	40	products	product	NNS
cord-016293-pyb00pt5	536	41	and	and	CC
cord-016293-pyb00pt5	536	42	applications	application	NNS
cord-016293-pyb00pt5	536	43	had	have	VBD
cord-016293-pyb00pt5	536	44	to	to	TO
cord-016293-pyb00pt5	536	45	be	be	VB
cord-016293-pyb00pt5	536	46	evaluated	evaluate	VBN
cord-016293-pyb00pt5	536	47	outside	outside	IN
cord-016293-pyb00pt5	536	48	the	the	DT
cord-016293-pyb00pt5	536	49	confines	confine	NNS
cord-016293-pyb00pt5	536	50	of	of	IN
cord-016293-pyb00pt5	536	51	a	a	DT
cord-016293-pyb00pt5	536	52	laboratory	laboratory	NN
cord-016293-pyb00pt5	536	53	.	.	.
cord-016293-pyb00pt5	537	1	However	however	RB
cord-016293-pyb00pt5	537	2	,	,	,
cord-016293-pyb00pt5	537	3	the	the	DT
cord-016293-pyb00pt5	537	4	specter	specter	NN
cord-016293-pyb00pt5	537	5	now	now	RB
cord-016293-pyb00pt5	537	6	became	become	VBD
cord-016293-pyb00pt5	537	7	far	far	RB
cord-016293-pyb00pt5	537	8	more	more	RBR
cord-016293-pyb00pt5	537	9	global	global	JJ
cord-016293-pyb00pt5	537	10	as	as	IN
cord-016293-pyb00pt5	537	11	the	the	DT
cord-016293-pyb00pt5	537	12	implications	implication	NNS
cord-016293-pyb00pt5	537	13	of	of	IN
cord-016293-pyb00pt5	537	14	commercial	commercial	JJ
cord-016293-pyb00pt5	537	15	applications	application	NNS
cord-016293-pyb00pt5	537	16	brought	bring	VBN
cord-016293-pyb00pt5	537	17	not	not	RB
cord-016293-pyb00pt5	537	18	just	just	RB
cord-016293-pyb00pt5	537	19	worker	worker	NN
cord-016293-pyb00pt5	537	20	safety	safety	NN
cord-016293-pyb00pt5	537	21	into	into	IN
cord-016293-pyb00pt5	537	22	the	the	DT
cord-016293-pyb00pt5	537	23	loop	loop	NN
cord-016293-pyb00pt5	537	24	but	but	CC
cord-016293-pyb00pt5	537	25	also	also	RB
cord-016293-pyb00pt5	537	26	,	,	,
cord-016293-pyb00pt5	537	27	the	the	DT
cord-016293-pyb00pt5	537	28	environment	environment	NN
cord-016293-pyb00pt5	537	29	,	,	,
cord-016293-pyb00pt5	537	30	agricultural	agricultural	JJ
cord-016293-pyb00pt5	537	31	and	and	CC
cord-016293-pyb00pt5	537	32	industrial	industrial	JJ
cord-016293-pyb00pt5	537	33	products	product	NNS
cord-016293-pyb00pt5	537	34	and	and	CC
cord-016293-pyb00pt5	537	35	the	the	DT
cord-016293-pyb00pt5	537	36	safety	safety	NN
cord-016293-pyb00pt5	537	37	and	and	CC
cord-016293-pyb00pt5	537	38	well	well	RB
cord-016293-pyb00pt5	537	39	being	be	VBG
cord-016293-pyb00pt5	537	40	of	of	IN
cord-016293-pyb00pt5	537	41	all	all	DT
cord-016293-pyb00pt5	537	42	living	live	VBG
cord-016293-pyb00pt5	537	43	things	thing	NNS
cord-016293-pyb00pt5	537	44	.	.	.
cord-016293-pyb00pt5	538	1	Beyond	beyond	IN
cord-016293-pyb00pt5	538	2	"	"	``
cord-016293-pyb00pt5	538	3	deliberate	deliberate	JJ
cord-016293-pyb00pt5	538	4	"	"	''
cord-016293-pyb00pt5	538	5	release	release	NN
cord-016293-pyb00pt5	538	6	,	,	,
cord-016293-pyb00pt5	538	7	the	the	DT
cord-016293-pyb00pt5	538	8	RAC	RAC	NNP
cord-016293-pyb00pt5	538	9	guidelines	guideline	NNS
cord-016293-pyb00pt5	538	10	were	be	VBD
cord-016293-pyb00pt5	538	11	not	not	RB
cord-016293-pyb00pt5	538	12	designed	design	VBN
cord-016293-pyb00pt5	538	13	to	to	TO
cord-016293-pyb00pt5	538	14	address	address	VB
cord-016293-pyb00pt5	538	15	these	these	DT
cord-016293-pyb00pt5	538	16	issues	issue	NNS
cord-016293-pyb00pt5	538	17	,	,	,
cord-016293-pyb00pt5	538	18	so	so	CC
cord-016293-pyb00pt5	538	19	the	the	DT
cord-016293-pyb00pt5	538	20	matter	matter	NN
cord-016293-pyb00pt5	538	21	moved	move	VBD
cord-016293-pyb00pt5	538	22	into	into	IN
cord-016293-pyb00pt5	538	23	the	the	DT
cord-016293-pyb00pt5	538	24	realm	realm	NN
cord-016293-pyb00pt5	538	25	of	of	IN
cord-016293-pyb00pt5	538	26	the	the	DT
cord-016293-pyb00pt5	538	27	federal	federal	JJ
cord-016293-pyb00pt5	538	28	agencies	agency	NNS
cord-016293-pyb00pt5	538	29	who	who	WP
cord-016293-pyb00pt5	538	30	had	have	VBD
cord-016293-pyb00pt5	538	31	regulatory	regulatory	JJ
cord-016293-pyb00pt5	538	32	authority	authority	NN
cord-016293-pyb00pt5	538	33	which	which	WDT
cord-016293-pyb00pt5	538	34	could	could	MD
cord-016293-pyb00pt5	538	35	be	be	VB
cord-016293-pyb00pt5	538	36	interpreted	interpret	VBN
cord-016293-pyb00pt5	538	37	to	to	TO
cord-016293-pyb00pt5	538	38	oversee	oversee	VB
cord-016293-pyb00pt5	538	39	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	538	40	issues	issue	NNS
cord-016293-pyb00pt5	538	41	.	.	.
cord-016293-pyb00pt5	539	1	This	this	DT
cord-016293-pyb00pt5	539	2	adaptation	adaptation	NN
cord-016293-pyb00pt5	539	3	of	of	IN
cord-016293-pyb00pt5	539	4	oversight	oversight	NN
cord-016293-pyb00pt5	539	5	is	be	VBZ
cord-016293-pyb00pt5	539	6	very	very	RB
cord-016293-pyb00pt5	539	7	much	much	RB
cord-016293-pyb00pt5	539	8	a	a	DT
cord-016293-pyb00pt5	539	9	dynamic	dynamic	JJ
cord-016293-pyb00pt5	539	10	process	process	NN
cord-016293-pyb00pt5	539	11	as	as	IN
cord-016293-pyb00pt5	539	12	the	the	DT
cord-016293-pyb00pt5	539	13	various	various	JJ
cord-016293-pyb00pt5	539	14	agencies	agency	NNS
cord-016293-pyb00pt5	539	15	wrestle	wrestle	VBP
cord-016293-pyb00pt5	539	16	with	with	IN
cord-016293-pyb00pt5	539	17	the	the	DT
cord-016293-pyb00pt5	539	18	task	task	NN
cord-016293-pyb00pt5	539	19	of	of	IN
cord-016293-pyb00pt5	539	20	applying	apply	VBG
cord-016293-pyb00pt5	539	21	existing	exist	VBG
cord-016293-pyb00pt5	539	22	regulations	regulation	NNS
cord-016293-pyb00pt5	539	23	and	and	CC
cord-016293-pyb00pt5	539	24	developing	develop	VBG
cord-016293-pyb00pt5	539	25	new	new	JJ
cord-016293-pyb00pt5	539	26	ones	one	NNS
cord-016293-pyb00pt5	539	27	for	for	IN
cord-016293-pyb00pt5	539	28	oversight	oversight	NN
cord-016293-pyb00pt5	539	29	of	of	IN
cord-016293-pyb00pt5	539	30	this	this	DT
cord-016293-pyb00pt5	539	31	technology	technology	NN
cord-016293-pyb00pt5	539	32	in	in	IN
cord-016293-pyb00pt5	539	33	transition	transition	NN
cord-016293-pyb00pt5	539	34	.	.	.
cord-016293-pyb00pt5	540	1	As	as	IN
cord-016293-pyb00pt5	540	2	the	the	DT
cord-016293-pyb00pt5	540	3	decade	decade	NN
cord-016293-pyb00pt5	540	4	progressed	progress	VBD
cord-016293-pyb00pt5	540	5	focus	focus	NN
cord-016293-pyb00pt5	540	6	shifted	shift	VBD
cord-016293-pyb00pt5	540	7	from	from	IN
cord-016293-pyb00pt5	540	8	basic	basic	JJ
cord-016293-pyb00pt5	540	9	biotic	biotic	JJ
cord-016293-pyb00pt5	540	10	stress	stress	NN
cord-016293-pyb00pt5	540	11	resistance	resistance	NN
cord-016293-pyb00pt5	540	12	to	to	IN
cord-016293-pyb00pt5	540	13	more	more	JJR
cord-016293-pyb00pt5	540	14	complex	complex	JJ
cord-016293-pyb00pt5	540	15	modifications	modification	NNS
cord-016293-pyb00pt5	540	16	The	the	DT
cord-016293-pyb00pt5	540	17	next	next	JJ
cord-016293-pyb00pt5	540	18	generation	generation	NN
cord-016293-pyb00pt5	540	19	of	of	IN
cord-016293-pyb00pt5	540	20	plants	plant	NNS
cord-016293-pyb00pt5	540	21	will	will	MD
cord-016293-pyb00pt5	540	22	focus	focus	VB
cord-016293-pyb00pt5	540	23	on	on	IN
cord-016293-pyb00pt5	540	24	value	value	NN
cord-016293-pyb00pt5	540	25	added	add	VBN
cord-016293-pyb00pt5	540	26	traits	trait	NNS
cord-016293-pyb00pt5	540	27	in	in	IN
cord-016293-pyb00pt5	540	28	which	which	WDT
cord-016293-pyb00pt5	540	29	valuable	valuable	JJ
cord-016293-pyb00pt5	540	30	genes	gene	NNS
cord-016293-pyb00pt5	540	31	and	and	CC
cord-016293-pyb00pt5	540	32	metabolites	metabolite	NNS
cord-016293-pyb00pt5	540	33	will	will	MD
cord-016293-pyb00pt5	540	34	be	be	VB
cord-016293-pyb00pt5	540	35	identified	identify	VBN
cord-016293-pyb00pt5	540	36	and	and	CC
cord-016293-pyb00pt5	540	37	isolated	isolate	VBN
cord-016293-pyb00pt5	540	38	,	,	,
cord-016293-pyb00pt5	540	39	with	with	IN
cord-016293-pyb00pt5	540	40	some	some	DT
cord-016293-pyb00pt5	540	41	of	of	IN
cord-016293-pyb00pt5	540	42	the	the	DT
cord-016293-pyb00pt5	540	43	later	later	JJ
cord-016293-pyb00pt5	540	44	compounds	compound	NNS
cord-016293-pyb00pt5	540	45	being	be	VBG
cord-016293-pyb00pt5	540	46	produced	produce	VBN
cord-016293-pyb00pt5	540	47	in	in	IN
cord-016293-pyb00pt5	540	48	mass	mass	JJ
cord-016293-pyb00pt5	540	49	quantities	quantity	NNS
cord-016293-pyb00pt5	540	50	for	for	IN
cord-016293-pyb00pt5	540	51	niche	niche	NN
cord-016293-pyb00pt5	540	52	markets	market	NNS
cord-016293-pyb00pt5	540	53	.	.	.
cord-016293-pyb00pt5	541	1	Two	two	CD
cord-016293-pyb00pt5	541	2	of	of	IN
cord-016293-pyb00pt5	541	3	the	the	DT
cord-016293-pyb00pt5	541	4	more	more	RBR
cord-016293-pyb00pt5	541	5	promising	promising	JJ
cord-016293-pyb00pt5	541	6	markets	market	NNS
cord-016293-pyb00pt5	541	7	are	be	VBP
cord-016293-pyb00pt5	541	8	nutraceuticals	nutraceutical	NNS
cord-016293-pyb00pt5	541	9	or	or	CC
cord-016293-pyb00pt5	541	10	so	so	RB
cord-016293-pyb00pt5	541	11	-	-	HYPH
cord-016293-pyb00pt5	541	12	called	call	VBN
cord-016293-pyb00pt5	541	13	"	"	``
cord-016293-pyb00pt5	541	14	Functional	Functional	NNP
cord-016293-pyb00pt5	541	15	Foods	Foods	NNPS
cord-016293-pyb00pt5	541	16	"	"	''
cord-016293-pyb00pt5	541	17	and	and	CC
cord-016293-pyb00pt5	541	18	plants	plant	NNS
cord-016293-pyb00pt5	541	19	developed	develop	VBN
cord-016293-pyb00pt5	541	20	as	as	IN
cord-016293-pyb00pt5	541	21	bioreactors	bioreactor	NNS
cord-016293-pyb00pt5	541	22	for	for	IN
cord-016293-pyb00pt5	541	23	the	the	DT
cord-016293-pyb00pt5	541	24	production	production	NN
cord-016293-pyb00pt5	541	25	of	of	IN
cord-016293-pyb00pt5	541	26	valuable	valuable	JJ
cord-016293-pyb00pt5	541	27	proteins	protein	NNS
cord-016293-pyb00pt5	541	28	and	and	CC
cord-016293-pyb00pt5	541	29	compounds	compound	NNS
cord-016293-pyb00pt5	541	30	,	,	,
cord-016293-pyb00pt5	541	31	a	a	DT
cord-016293-pyb00pt5	541	32	field	field	NN
cord-016293-pyb00pt5	541	33	known	know	VBN
cord-016293-pyb00pt5	541	34	as	as	IN
cord-016293-pyb00pt5	541	35	Plant	Plant	NNP
cord-016293-pyb00pt5	541	36	Molecular	Molecular	NNP
cord-016293-pyb00pt5	541	37	Farming	Farming	NNP
cord-016293-pyb00pt5	541	38	.	.	.
cord-016293-pyb00pt5	542	1	Developing	develop	VBG
cord-016293-pyb00pt5	542	2	plants	plant	NNS
cord-016293-pyb00pt5	542	3	with	with	IN
cord-016293-pyb00pt5	542	4	improved	improved	JJ
cord-016293-pyb00pt5	542	5	quality	quality	NN
cord-016293-pyb00pt5	542	6	traits	trait	NNS
cord-016293-pyb00pt5	542	7	involves	involve	VBZ
cord-016293-pyb00pt5	542	8	overcoming	overcome	VBG
cord-016293-pyb00pt5	542	9	a	a	DT
cord-016293-pyb00pt5	542	10	variety	variety	NN
cord-016293-pyb00pt5	542	11	of	of	IN
cord-016293-pyb00pt5	542	12	technical	technical	JJ
cord-016293-pyb00pt5	542	13	challenges	challenge	NNS
cord-016293-pyb00pt5	542	14	inherent	inherent	JJ
cord-016293-pyb00pt5	542	15	to	to	IN
cord-016293-pyb00pt5	542	16	metabolic	metabolic	JJ
cord-016293-pyb00pt5	542	17	engineering	engineering	NN
cord-016293-pyb00pt5	542	18	programs	program	NNS
cord-016293-pyb00pt5	542	19	.	.	.
cord-016293-pyb00pt5	543	1	Both	both	DT
cord-016293-pyb00pt5	543	2	traditional	traditional	JJ
cord-016293-pyb00pt5	543	3	plant	plant	NN
cord-016293-pyb00pt5	543	4	breeding	breeding	NN
cord-016293-pyb00pt5	543	5	and	and	CC
cord-016293-pyb00pt5	543	6	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	543	7	techniques	technique	NNS
cord-016293-pyb00pt5	543	8	are	be	VBP
cord-016293-pyb00pt5	543	9	needed	need	VBN
cord-016293-pyb00pt5	543	10	to	to	TO
cord-016293-pyb00pt5	543	11	produce	produce	VB
cord-016293-pyb00pt5	543	12	plants	plant	NNS
cord-016293-pyb00pt5	543	13	carrying	carry	VBG
cord-016293-pyb00pt5	543	14	the	the	DT
cord-016293-pyb00pt5	543	15	desired	desire	VBN
cord-016293-pyb00pt5	543	16	quality	quality	NN
cord-016293-pyb00pt5	543	17	traits	trait	NNS
cord-016293-pyb00pt5	543	18	.	.	.
cord-016293-pyb00pt5	544	1	Continuing	continue	VBG
cord-016293-pyb00pt5	544	2	improvements	improvement	NNS
cord-016293-pyb00pt5	544	3	in	in	IN
cord-016293-pyb00pt5	544	4	molecular	molecular	JJ
cord-016293-pyb00pt5	544	5	and	and	CC
cord-016293-pyb00pt5	544	6	genomic	genomic	JJ
cord-016293-pyb00pt5	544	7	technologies	technology	NNS
cord-016293-pyb00pt5	544	8	are	be	VBP
cord-016293-pyb00pt5	544	9	contributing	contribute	VBG
cord-016293-pyb00pt5	544	10	to	to	IN
cord-016293-pyb00pt5	544	11	the	the	DT
cord-016293-pyb00pt5	544	12	acceleration	acceleration	NN
cord-016293-pyb00pt5	544	13	of	of	IN
cord-016293-pyb00pt5	544	14	product	product	NN
cord-016293-pyb00pt5	544	15	development	development	NN
cord-016293-pyb00pt5	544	16	in	in	IN
cord-016293-pyb00pt5	544	17	this	this	DT
cord-016293-pyb00pt5	544	18	space	space	NN
cord-016293-pyb00pt5	544	19	.	.	.
cord-016293-pyb00pt5	545	1	By	by	IN
cord-016293-pyb00pt5	545	2	the	the	DT
cord-016293-pyb00pt5	545	3	end	end	NN
cord-016293-pyb00pt5	545	4	of	of	IN
cord-016293-pyb00pt5	545	5	the	the	DT
cord-016293-pyb00pt5	545	6	decade	decade	NN
cord-016293-pyb00pt5	545	7	in	in	IN
cord-016293-pyb00pt5	545	8	1999	1999	CD
cord-016293-pyb00pt5	545	9	,	,	,
cord-016293-pyb00pt5	545	10	applying	apply	VBG
cord-016293-pyb00pt5	545	11	nutritional	nutritional	JJ
cord-016293-pyb00pt5	545	12	genomics	genomic	NNS
cord-016293-pyb00pt5	545	13	,	,	,
cord-016293-pyb00pt5	545	14	Della	Della	NNP
cord-016293-pyb00pt5	545	15	Penna	Penna	NNP
cord-016293-pyb00pt5	545	16	(	(	-LRB-
cord-016293-pyb00pt5	545	17	1999	1999	CD
cord-016293-pyb00pt5	545	18	)	)	-RRB-
cord-016293-pyb00pt5	545	19	isolated	isolate	VBD
cord-016293-pyb00pt5	545	20	a	a	DT
cord-016293-pyb00pt5	545	21	gene	gene	NN
cord-016293-pyb00pt5	545	22	,	,	,
cord-016293-pyb00pt5	545	23	which	which	WDT
cord-016293-pyb00pt5	545	24	converts	convert	VBZ
cord-016293-pyb00pt5	545	25	the	the	DT
cord-016293-pyb00pt5	545	26	lower	low	JJR
cord-016293-pyb00pt5	545	27	activity	activity	NN
cord-016293-pyb00pt5	545	28	precursors	precursor	NNS
cord-016293-pyb00pt5	545	29	to	to	IN
cord-016293-pyb00pt5	545	30	the	the	DT
cord-016293-pyb00pt5	545	31	highest	high	JJS
cord-016293-pyb00pt5	545	32	activity	activity	NN
cord-016293-pyb00pt5	545	33	vitamin	vitamin	NN
cord-016293-pyb00pt5	545	34	E	e	NN
cord-016293-pyb00pt5	545	35	compound	compound	NN
cord-016293-pyb00pt5	545	36	,	,	,
cord-016293-pyb00pt5	545	37	alpha	alpha	NN
cord-016293-pyb00pt5	545	38	-	-	HYPH
cord-016293-pyb00pt5	545	39	tocopherol	tocopherol	NN
cord-016293-pyb00pt5	545	40	.	.	.
cord-016293-pyb00pt5	546	1	With	with	IN
cord-016293-pyb00pt5	546	2	this	this	DT
cord-016293-pyb00pt5	546	3	technology	technology	NN
cord-016293-pyb00pt5	546	4	,	,	,
cord-016293-pyb00pt5	546	5	the	the	DT
cord-016293-pyb00pt5	546	6	vitamin	vitamin	NN
cord-016293-pyb00pt5	546	7	E	e	NN
cord-016293-pyb00pt5	546	8	content	content	NN
cord-016293-pyb00pt5	546	9	of	of	IN
cord-016293-pyb00pt5	546	10	Arabidopsis	Arabidopsis	NNP
cord-016293-pyb00pt5	546	11	seed	seed	NN
cord-016293-pyb00pt5	546	12	oil	oil	NN
cord-016293-pyb00pt5	546	13	has	have	VBZ
cord-016293-pyb00pt5	546	14	been	be	VBN
cord-016293-pyb00pt5	546	15	increased	increase	VBN
cord-016293-pyb00pt5	546	16	nearly	nearly	RB
cord-016293-pyb00pt5	546	17	10-fold	10-fold	JJ
cord-016293-pyb00pt5	546	18	and	and	CC
cord-016293-pyb00pt5	546	19	progress	progress	NN
cord-016293-pyb00pt5	546	20	has	have	VBZ
cord-016293-pyb00pt5	546	21	been	be	VBN
cord-016293-pyb00pt5	546	22	made	make	VBN
cord-016293-pyb00pt5	546	23	to	to	TO
cord-016293-pyb00pt5	546	24	move	move	VB
cord-016293-pyb00pt5	546	25	the	the	DT
cord-016293-pyb00pt5	546	26	technology	technology	NN
cord-016293-pyb00pt5	546	27	to	to	IN
cord-016293-pyb00pt5	546	28	crops	crop	NNS
cord-016293-pyb00pt5	546	29	such	such	JJ
cord-016293-pyb00pt5	546	30	as	as	IN
cord-016293-pyb00pt5	546	31	soybean	soybean	NN
cord-016293-pyb00pt5	546	32	,	,	,
cord-016293-pyb00pt5	546	33	maize	maize	NN
cord-016293-pyb00pt5	546	34	,	,	,
cord-016293-pyb00pt5	546	35	and	and	CC
cord-016293-pyb00pt5	546	36	canola	canola	NN
cord-016293-pyb00pt5	546	37	.	.	.
cord-016293-pyb00pt5	547	1	This	this	DT
cord-016293-pyb00pt5	547	2	has	have	VBZ
cord-016293-pyb00pt5	547	3	also	also	RB
cord-016293-pyb00pt5	547	4	been	be	VBN
cord-016293-pyb00pt5	547	5	done	do	VBN
cord-016293-pyb00pt5	547	6	for	for	IN
cord-016293-pyb00pt5	547	7	folates	folate	NNS
cord-016293-pyb00pt5	547	8	in	in	IN
cord-016293-pyb00pt5	547	9	rice	rice	NN
cord-016293-pyb00pt5	547	10	.	.	.
cord-016293-pyb00pt5	548	1	Omega	omega	NN
cord-016293-pyb00pt5	548	2	three	three	CD
cord-016293-pyb00pt5	548	3	fatty	fatty	JJ
cord-016293-pyb00pt5	548	4	acids	acid	NNS
cord-016293-pyb00pt5	548	5	play	play	VBP
cord-016293-pyb00pt5	548	6	a	a	DT
cord-016293-pyb00pt5	548	7	significant	significant	JJ
cord-016293-pyb00pt5	548	8	role	role	NN
cord-016293-pyb00pt5	548	9	in	in	IN
cord-016293-pyb00pt5	548	10	human	human	JJ
cord-016293-pyb00pt5	548	11	health	health	NN
cord-016293-pyb00pt5	548	12	,	,	,
cord-016293-pyb00pt5	548	13	eicosapentaenoic	eicosapentaenoic	JJ
cord-016293-pyb00pt5	548	14	acid	acid	NN
cord-016293-pyb00pt5	548	15	(	(	-LRB-
cord-016293-pyb00pt5	548	16	EPA	EPA	NNP
cord-016293-pyb00pt5	548	17	)	)	-RRB-
cord-016293-pyb00pt5	548	18	and	and	CC
cord-016293-pyb00pt5	548	19	docosahexaenoic	docosahexaenoic	NNP
cord-016293-pyb00pt5	548	20	acid	acid	NNP
cord-016293-pyb00pt5	548	21	(	(	-LRB-
cord-016293-pyb00pt5	548	22	DHA	DHA	NNP
cord-016293-pyb00pt5	548	23	)	)	-RRB-
cord-016293-pyb00pt5	548	24	,	,	,
cord-016293-pyb00pt5	548	25	which	which	WDT
cord-016293-pyb00pt5	548	26	are	be	VBP
cord-016293-pyb00pt5	548	27	present	present	JJ
cord-016293-pyb00pt5	548	28	in	in	IN
cord-016293-pyb00pt5	548	29	the	the	DT
cord-016293-pyb00pt5	548	30	retina	retina	NN
cord-016293-pyb00pt5	548	31	of	of	IN
cord-016293-pyb00pt5	548	32	the	the	DT
cord-016293-pyb00pt5	548	33	eye	eye	NN
cord-016293-pyb00pt5	548	34	and	and	CC
cord-016293-pyb00pt5	548	35	cerebral	cerebral	JJ
cord-016293-pyb00pt5	548	36	cortex	cortex	NN
cord-016293-pyb00pt5	548	37	of	of	IN
cord-016293-pyb00pt5	548	38	the	the	DT
cord-016293-pyb00pt5	548	39	brain	brain	NN
cord-016293-pyb00pt5	548	40	,	,	,
cord-016293-pyb00pt5	548	41	respectively	respectively	RB
cord-016293-pyb00pt5	548	42	,	,	,
cord-016293-pyb00pt5	548	43	are	be	VBP
cord-016293-pyb00pt5	548	44	some	some	DT
cord-016293-pyb00pt5	548	45	of	of	IN
cord-016293-pyb00pt5	548	46	the	the	DT
cord-016293-pyb00pt5	548	47	most	most	RBS
cord-016293-pyb00pt5	548	48	well	well	RB
cord-016293-pyb00pt5	548	49	documented	document	VBN
cord-016293-pyb00pt5	548	50	from	from	IN
cord-016293-pyb00pt5	548	51	a	a	DT
cord-016293-pyb00pt5	548	52	clinical	clinical	JJ
cord-016293-pyb00pt5	548	53	perspective	perspective	NN
cord-016293-pyb00pt5	548	54	.	.	.
cord-016293-pyb00pt5	549	1	It	-PRON-	PRP
cord-016293-pyb00pt5	549	2	is	be	VBZ
cord-016293-pyb00pt5	549	3	believed	believe	VBN
cord-016293-pyb00pt5	549	4	that	that	IN
cord-016293-pyb00pt5	549	5	EPA	EPA	NNP
cord-016293-pyb00pt5	549	6	and	and	CC
cord-016293-pyb00pt5	549	7	DHA	DHA	NNP
cord-016293-pyb00pt5	549	8	play	play	VBP
cord-016293-pyb00pt5	549	9	an	an	DT
cord-016293-pyb00pt5	549	10	important	important	JJ
cord-016293-pyb00pt5	549	11	role	role	NN
cord-016293-pyb00pt5	549	12	in	in	IN
cord-016293-pyb00pt5	549	13	the	the	DT
cord-016293-pyb00pt5	549	14	regulation	regulation	NN
cord-016293-pyb00pt5	549	15	of	of	IN
cord-016293-pyb00pt5	549	16	inflammatory	inflammatory	JJ
cord-016293-pyb00pt5	549	17	immune	immune	JJ
cord-016293-pyb00pt5	549	18	reactions	reaction	NNS
cord-016293-pyb00pt5	549	19	and	and	CC
cord-016293-pyb00pt5	549	20	blood	blood	NN
cord-016293-pyb00pt5	549	21	pressure	pressure	NN
cord-016293-pyb00pt5	549	22	,	,	,
cord-016293-pyb00pt5	549	23	treatment	treatment	NN
cord-016293-pyb00pt5	549	24	of	of	IN
cord-016293-pyb00pt5	549	25	conditions	condition	NNS
cord-016293-pyb00pt5	549	26	such	such	JJ
cord-016293-pyb00pt5	549	27	as	as	IN
cord-016293-pyb00pt5	549	28	cardiovascular	cardiovascular	JJ
cord-016293-pyb00pt5	549	29	disease	disease	NN
cord-016293-pyb00pt5	549	30	and	and	CC
cord-016293-pyb00pt5	549	31	cystic	cystic	JJ
cord-016293-pyb00pt5	549	32	fibrosis	fibrosis	NN
cord-016293-pyb00pt5	549	33	,	,	,
cord-016293-pyb00pt5	549	34	brain	brain	NN
cord-016293-pyb00pt5	549	35	development	development	NN
cord-016293-pyb00pt5	549	36	in	in	IN
cord-016293-pyb00pt5	549	37	utero	utero	NN
cord-016293-pyb00pt5	549	38	,	,	,
cord-016293-pyb00pt5	549	39	and	and	CC
cord-016293-pyb00pt5	549	40	,	,	,
cord-016293-pyb00pt5	549	41	in	in	IN
cord-016293-pyb00pt5	549	42	early	early	JJ
cord-016293-pyb00pt5	549	43	postnatal	postnatal	JJ
cord-016293-pyb00pt5	549	44	life	life	NN
cord-016293-pyb00pt5	549	45	,	,	,
cord-016293-pyb00pt5	549	46	the	the	DT
cord-016293-pyb00pt5	549	47	development	development	NN
cord-016293-pyb00pt5	549	48	of	of	IN
cord-016293-pyb00pt5	549	49	cognitive	cognitive	JJ
cord-016293-pyb00pt5	549	50	function	function	NN
cord-016293-pyb00pt5	549	51	.	.	.
cord-016293-pyb00pt5	550	1	They	-PRON-	PRP
cord-016293-pyb00pt5	550	2	are	be	VBP
cord-016293-pyb00pt5	550	3	mainly	mainly	RB
cord-016293-pyb00pt5	550	4	found	find	VBN
cord-016293-pyb00pt5	550	5	in	in	IN
cord-016293-pyb00pt5	550	6	fish	fish	NN
cord-016293-pyb00pt5	550	7	oil	oil	NN
cord-016293-pyb00pt5	550	8	and	and	CC
cord-016293-pyb00pt5	550	9	the	the	DT
cord-016293-pyb00pt5	550	10	supply	supply	NN
cord-016293-pyb00pt5	550	11	is	be	VBZ
cord-016293-pyb00pt5	550	12	limited	limit	VBN
cord-016293-pyb00pt5	550	13	.	.	.
cord-016293-pyb00pt5	551	1	By	by	IN
cord-016293-pyb00pt5	551	2	the	the	DT
cord-016293-pyb00pt5	551	3	end	end	NN
cord-016293-pyb00pt5	551	4	of	of	IN
cord-016293-pyb00pt5	551	5	the	the	DT
cord-016293-pyb00pt5	551	6	decade	decade	NN
cord-016293-pyb00pt5	551	7	Ursin	Ursin	NNP
cord-016293-pyb00pt5	551	8	(	(	-LRB-
cord-016293-pyb00pt5	551	9	2000	2000	CD
cord-016293-pyb00pt5	551	10	)	)	-RRB-
cord-016293-pyb00pt5	551	11	had	have	VBD
cord-016293-pyb00pt5	551	12	succeeded	succeed	VBN
cord-016293-pyb00pt5	551	13	in	in	IN
cord-016293-pyb00pt5	551	14	engineering	engineering	NN
cord-016293-pyb00pt5	551	15	canola	canola	NN
cord-016293-pyb00pt5	551	16	to	to	TO
cord-016293-pyb00pt5	551	17	produce	produce	VB
cord-016293-pyb00pt5	551	18	these	these	DT
cord-016293-pyb00pt5	551	19	fatty	fatty	JJ
cord-016293-pyb00pt5	551	20	acids	acid	NNS
cord-016293-pyb00pt5	551	21	.	.	.
cord-016293-pyb00pt5	552	1	From	from	IN
cord-016293-pyb00pt5	552	2	a	a	DT
cord-016293-pyb00pt5	552	3	global	global	JJ
cord-016293-pyb00pt5	552	4	perspective	perspective	NN
cord-016293-pyb00pt5	552	5	another	another	DT
cord-016293-pyb00pt5	552	6	value	value	NN
cord-016293-pyb00pt5	552	7	-	-	HYPH
cord-016293-pyb00pt5	552	8	added	add	VBN
cord-016293-pyb00pt5	552	9	development	development	NN
cord-016293-pyb00pt5	552	10	had	have	VBD
cord-016293-pyb00pt5	552	11	far	far	RB
cord-016293-pyb00pt5	552	12	greater	great	JJR
cord-016293-pyb00pt5	552	13	impact	impact	NN
cord-016293-pyb00pt5	552	14	both	both	CC
cord-016293-pyb00pt5	552	15	technologically	technologically	JJ
cord-016293-pyb00pt5	552	16	and	and	CC
cord-016293-pyb00pt5	552	17	socio	socio	JJ
cord-016293-pyb00pt5	552	18	-	-	JJ
cord-016293-pyb00pt5	552	19	economically	economically	RB
cord-016293-pyb00pt5	552	20	.	.	.
cord-016293-pyb00pt5	553	1	A	a	DT
cord-016293-pyb00pt5	553	2	team	team	NN
cord-016293-pyb00pt5	553	3	led	lead	VBN
cord-016293-pyb00pt5	553	4	by	by	IN
cord-016293-pyb00pt5	553	5	Ingo	Ingo	NNP
cord-016293-pyb00pt5	553	6	Potrykus	Potrykus	NNP
cord-016293-pyb00pt5	553	7	(	(	-LRB-
cord-016293-pyb00pt5	553	8	1999	1999	CD
cord-016293-pyb00pt5	553	9	)	)	-RRB-
cord-016293-pyb00pt5	553	10	engineered	engineer	VBD
cord-016293-pyb00pt5	553	11	rice	rice	NN
cord-016293-pyb00pt5	553	12	to	to	TO
cord-016293-pyb00pt5	553	13	produce	produce	VB
cord-016293-pyb00pt5	553	14	pro	pro	JJ
cord-016293-pyb00pt5	553	15	-	-	JJ
cord-016293-pyb00pt5	553	16	Vitamin	vitamin	JJ
cord-016293-pyb00pt5	553	17	A	a	NN
cord-016293-pyb00pt5	553	18	,	,	,
cord-016293-pyb00pt5	553	19	which	which	WDT
cord-016293-pyb00pt5	553	20	is	be	VBZ
cord-016293-pyb00pt5	553	21	an	an	DT
cord-016293-pyb00pt5	553	22	essential	essential	JJ
cord-016293-pyb00pt5	553	23	micronutrient	micronutrient	NN
cord-016293-pyb00pt5	553	24	.	.	.
cord-016293-pyb00pt5	554	1	Widespread	widespread	JJ
cord-016293-pyb00pt5	554	2	dietary	dietary	JJ
cord-016293-pyb00pt5	554	3	deficiency	deficiency	NN
cord-016293-pyb00pt5	554	4	of	of	IN
cord-016293-pyb00pt5	554	5	this	this	DT
cord-016293-pyb00pt5	554	6	vitamin	vitamin	NN
cord-016293-pyb00pt5	554	7	in	in	IN
cord-016293-pyb00pt5	554	8	rice	rice	NN
cord-016293-pyb00pt5	554	9	-	-	HYPH
cord-016293-pyb00pt5	554	10	eating	eat	VBG
cord-016293-pyb00pt5	554	11	Asian	asian	JJ
cord-016293-pyb00pt5	554	12	countries	country	NNS
cord-016293-pyb00pt5	554	13	,	,	,
cord-016293-pyb00pt5	554	14	which	which	WDT
cord-016293-pyb00pt5	554	15	predisposes	predispose	VBZ
cord-016293-pyb00pt5	554	16	children	child	NNS
cord-016293-pyb00pt5	554	17	to	to	IN
cord-016293-pyb00pt5	554	18	diseases	disease	NNS
cord-016293-pyb00pt5	554	19	such	such	JJ
cord-016293-pyb00pt5	554	20	as	as	IN
cord-016293-pyb00pt5	554	21	blindness	blindness	NN
cord-016293-pyb00pt5	554	22	and	and	CC
cord-016293-pyb00pt5	554	23	measles	measle	NNS
cord-016293-pyb00pt5	554	24	,	,	,
cord-016293-pyb00pt5	554	25	has	have	VBZ
cord-016293-pyb00pt5	554	26	tragic	tragic	JJ
cord-016293-pyb00pt5	554	27	consequences	consequence	NNS
cord-016293-pyb00pt5	554	28	.	.	.
cord-016293-pyb00pt5	555	1	Improved	improve	VBN
cord-016293-pyb00pt5	555	2	vitamin	vitamin	NN
cord-016293-pyb00pt5	555	3	A	a	DT
cord-016293-pyb00pt5	555	4	nutrition	nutrition	NN
cord-016293-pyb00pt5	555	5	would	would	MD
cord-016293-pyb00pt5	555	6	alleviate	alleviate	VB
cord-016293-pyb00pt5	555	7	serious	serious	JJ
cord-016293-pyb00pt5	555	8	health	health	NN
cord-016293-pyb00pt5	555	9	problems	problem	NNS
cord-016293-pyb00pt5	555	10	and	and	CC
cord-016293-pyb00pt5	555	11	,	,	,
cord-016293-pyb00pt5	555	12	according	accord	VBG
cord-016293-pyb00pt5	555	13	to	to	IN
cord-016293-pyb00pt5	555	14	UNICEF	UNICEF	NNP
cord-016293-pyb00pt5	555	15	,	,	,
cord-016293-pyb00pt5	555	16	could	could	MD
cord-016293-pyb00pt5	555	17	also	also	RB
cord-016293-pyb00pt5	555	18	prevent	prevent	VB
cord-016293-pyb00pt5	555	19	up	up	RP
cord-016293-pyb00pt5	555	20	to	to	TO
cord-016293-pyb00pt5	555	21	two	two	CD
cord-016293-pyb00pt5	555	22	million	million	CD
cord-016293-pyb00pt5	555	23	infant	infant	NN
cord-016293-pyb00pt5	555	24	deaths	death	NNS
cord-016293-pyb00pt5	555	25	due	due	JJ
cord-016293-pyb00pt5	555	26	to	to	IN
cord-016293-pyb00pt5	555	27	vitamin	vitamin	NN
cord-016293-pyb00pt5	555	28	A	a	DT
cord-016293-pyb00pt5	555	29	deficiency	deficiency	NN
cord-016293-pyb00pt5	555	30	.	.	.
cord-016293-pyb00pt5	556	1	Adoption	adoption	NN
cord-016293-pyb00pt5	556	2	of	of	IN
cord-016293-pyb00pt5	556	3	the	the	DT
cord-016293-pyb00pt5	556	4	next	next	JJ
cord-016293-pyb00pt5	556	5	stage	stage	NN
cord-016293-pyb00pt5	556	6	of	of	IN
cord-016293-pyb00pt5	556	7	GM	GM	NNP
cord-016293-pyb00pt5	556	8	crops	crop	NNS
cord-016293-pyb00pt5	556	9	may	may	MD
cord-016293-pyb00pt5	556	10	proceed	proceed	VB
cord-016293-pyb00pt5	556	11	more	more	RBR
cord-016293-pyb00pt5	556	12	slowly	slowly	RB
cord-016293-pyb00pt5	556	13	,	,	,
cord-016293-pyb00pt5	556	14	as	as	IN
cord-016293-pyb00pt5	556	15	the	the	DT
cord-016293-pyb00pt5	556	16	market	market	NN
cord-016293-pyb00pt5	556	17	confronts	confront	VBZ
cord-016293-pyb00pt5	556	18	issues	issue	NNS
cord-016293-pyb00pt5	556	19	of	of	IN
cord-016293-pyb00pt5	556	20	how	how	WRB
cord-016293-pyb00pt5	556	21	to	to	TO
cord-016293-pyb00pt5	556	22	determine	determine	VB
cord-016293-pyb00pt5	556	23	price	price	NN
cord-016293-pyb00pt5	556	24	,	,	,
cord-016293-pyb00pt5	556	25	share	share	NN
cord-016293-pyb00pt5	556	26	value	value	NN
cord-016293-pyb00pt5	556	27	,	,	,
cord-016293-pyb00pt5	556	28	and	and	CC
cord-016293-pyb00pt5	556	29	adjust	adjust	VB
cord-016293-pyb00pt5	556	30	marketing	marketing	NN
cord-016293-pyb00pt5	556	31	and	and	CC
cord-016293-pyb00pt5	556	32	handling	handling	NN
cord-016293-pyb00pt5	556	33	to	to	TO
cord-016293-pyb00pt5	556	34	accommodate	accommodate	VB
cord-016293-pyb00pt5	556	35	specialized	specialized	JJ
cord-016293-pyb00pt5	556	36	end	end	NN
cord-016293-pyb00pt5	556	37	-	-	HYPH
cord-016293-pyb00pt5	556	38	use	use	NN
cord-016293-pyb00pt5	556	39	characteristics	characteristic	NNS
cord-016293-pyb00pt5	556	40	.	.	.
cord-016293-pyb00pt5	557	1	Furthermore	furthermore	RB
cord-016293-pyb00pt5	557	2	,	,	,
cord-016293-pyb00pt5	557	3	competition	competition	NN
cord-016293-pyb00pt5	557	4	from	from	IN
cord-016293-pyb00pt5	557	5	existing	exist	VBG
cord-016293-pyb00pt5	557	6	products	product	NNS
cord-016293-pyb00pt5	557	7	will	will	MD
cord-016293-pyb00pt5	557	8	not	not	RB
cord-016293-pyb00pt5	557	9	evaporate	evaporate	VB
cord-016293-pyb00pt5	557	10	.	.	.
cord-016293-pyb00pt5	558	1	Challenges	challenge	NNS
cord-016293-pyb00pt5	558	2	that	that	WDT
cord-016293-pyb00pt5	558	3	have	have	VBP
cord-016293-pyb00pt5	558	4	accompanied	accompany	VBN
cord-016293-pyb00pt5	558	5	GM	GM	NNP
cord-016293-pyb00pt5	558	6	crops	crop	NNS
cord-016293-pyb00pt5	558	7	with	with	IN
cord-016293-pyb00pt5	558	8	improved	improve	VBN
cord-016293-pyb00pt5	558	9	agronomic	agronomic	JJ
cord-016293-pyb00pt5	558	10	traits	trait	NNS
cord-016293-pyb00pt5	558	11	,	,	,
cord-016293-pyb00pt5	558	12	such	such	JJ
cord-016293-pyb00pt5	558	13	as	as	IN
cord-016293-pyb00pt5	558	14	the	the	DT
cord-016293-pyb00pt5	558	15	stalled	stall	VBN
cord-016293-pyb00pt5	558	16	regulatory	regulatory	JJ
cord-016293-pyb00pt5	558	17	processes	process	NNS
cord-016293-pyb00pt5	558	18	in	in	IN
cord-016293-pyb00pt5	558	19	Europe	Europe	NNP
cord-016293-pyb00pt5	558	20	,	,	,
cord-016293-pyb00pt5	558	21	will	will	MD
cord-016293-pyb00pt5	558	22	also	also	RB
cord-016293-pyb00pt5	558	23	affect	affect	VB
cord-016293-pyb00pt5	558	24	adoption	adoption	NN
cord-016293-pyb00pt5	558	25	of	of	IN
cord-016293-pyb00pt5	558	26	nutritionally	nutritionally	RB
cord-016293-pyb00pt5	558	27	improved	improve	VBN
cord-016293-pyb00pt5	558	28	GM	GM	NNP
cord-016293-pyb00pt5	558	29	products	product	NNS
cord-016293-pyb00pt5	558	30	.	.	.
cord-016293-pyb00pt5	559	1	Beyond	beyond	IN
cord-016293-pyb00pt5	559	2	all	all	DT
cord-016293-pyb00pt5	559	3	of	of	IN
cord-016293-pyb00pt5	559	4	this	this	DT
cord-016293-pyb00pt5	559	5	,	,	,
cord-016293-pyb00pt5	559	6	credible	credible	JJ
cord-016293-pyb00pt5	559	7	scientific	scientific	JJ
cord-016293-pyb00pt5	559	8	research	research	NN
cord-016293-pyb00pt5	559	9	is	be	VBZ
cord-016293-pyb00pt5	559	10	still	still	RB
cord-016293-pyb00pt5	559	11	needed	need	VBN
cord-016293-pyb00pt5	559	12	to	to	TO
cord-016293-pyb00pt5	559	13	confirm	confirm	VB
cord-016293-pyb00pt5	559	14	the	the	DT
cord-016293-pyb00pt5	559	15	benefits	benefit	NNS
cord-016293-pyb00pt5	559	16	of	of	IN
cord-016293-pyb00pt5	559	17	any	any	DT
cord-016293-pyb00pt5	559	18	particular	particular	JJ
cord-016293-pyb00pt5	559	19	food	food	NN
cord-016293-pyb00pt5	559	20	or	or	CC
cord-016293-pyb00pt5	559	21	component	component	NN
cord-016293-pyb00pt5	559	22	.	.	.
cord-016293-pyb00pt5	560	1	For	for	IN
cord-016293-pyb00pt5	560	2	functional	functional	JJ
cord-016293-pyb00pt5	560	3	foods	food	NNS
cord-016293-pyb00pt5	560	4	to	to	TO
cord-016293-pyb00pt5	560	5	deliver	deliver	VB
cord-016293-pyb00pt5	560	6	their	-PRON-	PRP$
cord-016293-pyb00pt5	560	7	potential	potential	JJ
cord-016293-pyb00pt5	560	8	public	public	JJ
cord-016293-pyb00pt5	560	9	health	health	NN
cord-016293-pyb00pt5	560	10	benefits	benefit	NNS
cord-016293-pyb00pt5	560	11	,	,	,
cord-016293-pyb00pt5	560	12	consumers	consumer	NNS
cord-016293-pyb00pt5	560	13	must	must	MD
cord-016293-pyb00pt5	560	14	have	have	VB
cord-016293-pyb00pt5	560	15	a	a	DT
cord-016293-pyb00pt5	560	16	clear	clear	JJ
cord-016293-pyb00pt5	560	17	understanding	understanding	NN
cord-016293-pyb00pt5	560	18	of	of	IN
cord-016293-pyb00pt5	560	19	,	,	,
cord-016293-pyb00pt5	560	20	and	and	CC
cord-016293-pyb00pt5	560	21	a	a	DT
cord-016293-pyb00pt5	560	22	strong	strong	JJ
cord-016293-pyb00pt5	560	23	confidence	confidence	NN
cord-016293-pyb00pt5	560	24	level	level	NN
cord-016293-pyb00pt5	560	25	in	in	IN
cord-016293-pyb00pt5	560	26	,	,	,
cord-016293-pyb00pt5	560	27	the	the	DT
cord-016293-pyb00pt5	560	28	scientific	scientific	JJ
cord-016293-pyb00pt5	560	29	criteria	criterion	NNS
cord-016293-pyb00pt5	560	30	that	that	WDT
cord-016293-pyb00pt5	560	31	are	be	VBP
cord-016293-pyb00pt5	560	32	used	use	VBN
cord-016293-pyb00pt5	560	33	to	to	TO
cord-016293-pyb00pt5	560	34	document	document	VB
cord-016293-pyb00pt5	560	35	health	health	NN
cord-016293-pyb00pt5	560	36	effects	effect	NNS
cord-016293-pyb00pt5	560	37	and	and	CC
cord-016293-pyb00pt5	560	38	claims	claim	NNS
cord-016293-pyb00pt5	560	39	.	.	.
cord-016293-pyb00pt5	561	1	Because	because	IN
cord-016293-pyb00pt5	561	2	these	these	DT
cord-016293-pyb00pt5	561	3	decisions	decision	NNS
cord-016293-pyb00pt5	561	4	will	will	MD
cord-016293-pyb00pt5	561	5	require	require	VB
cord-016293-pyb00pt5	561	6	an	an	DT
cord-016293-pyb00pt5	561	7	understanding	understanding	NN
cord-016293-pyb00pt5	561	8	of	of	IN
cord-016293-pyb00pt5	561	9	plant	plant	NN
cord-016293-pyb00pt5	561	10	biochemistry	biochemistry	NN
cord-016293-pyb00pt5	561	11	,	,	,
cord-016293-pyb00pt5	561	12	mammalian	mammalian	JJ
cord-016293-pyb00pt5	561	13	physiology	physiology	NN
cord-016293-pyb00pt5	561	14	,	,	,
cord-016293-pyb00pt5	561	15	and	and	CC
cord-016293-pyb00pt5	561	16	food	food	NN
cord-016293-pyb00pt5	561	17	chemistry	chemistry	NN
cord-016293-pyb00pt5	561	18	,	,	,
cord-016293-pyb00pt5	561	19	strong	strong	JJ
cord-016293-pyb00pt5	561	20	interdisciplinary	interdisciplinary	JJ
cord-016293-pyb00pt5	561	21	collaborations	collaboration	NNS
cord-016293-pyb00pt5	561	22	will	will	MD
cord-016293-pyb00pt5	561	23	be	be	VB
cord-016293-pyb00pt5	561	24	needed	need	VBN
cord-016293-pyb00pt5	561	25	among	among	IN
cord-016293-pyb00pt5	561	26	plant	plant	NN
cord-016293-pyb00pt5	561	27	scientists	scientist	NNS
cord-016293-pyb00pt5	561	28	,	,	,
cord-016293-pyb00pt5	561	29	nutritionists	nutritionist	NNS
cord-016293-pyb00pt5	561	30	,	,	,
cord-016293-pyb00pt5	561	31	and	and	CC
cord-016293-pyb00pt5	561	32	food	food	NN
cord-016293-pyb00pt5	561	33	scientists	scientist	NNS
cord-016293-pyb00pt5	561	34	to	to	TO
cord-016293-pyb00pt5	561	35	ensure	ensure	VB
cord-016293-pyb00pt5	561	36	a	a	DT
cord-016293-pyb00pt5	561	37	safe	safe	JJ
cord-016293-pyb00pt5	561	38	and	and	CC
cord-016293-pyb00pt5	561	39	healthful	healthful	JJ
cord-016293-pyb00pt5	561	40	food	food	NN
cord-016293-pyb00pt5	561	41	supply	supply	NN
cord-016293-pyb00pt5	561	42	.	.	.
cord-016293-pyb00pt5	562	1	In	in	IN
cord-016293-pyb00pt5	562	2	addition	addition	NN
cord-016293-pyb00pt5	562	3	to	to	IN
cord-016293-pyb00pt5	562	4	being	be	VBG
cord-016293-pyb00pt5	562	5	a	a	DT
cord-016293-pyb00pt5	562	6	source	source	NN
cord-016293-pyb00pt5	562	7	of	of	IN
cord-016293-pyb00pt5	562	8	nutrition	nutrition	NN
cord-016293-pyb00pt5	562	9	,	,	,
cord-016293-pyb00pt5	562	10	plants	plant	NNS
cord-016293-pyb00pt5	562	11	have	have	VBP
cord-016293-pyb00pt5	562	12	been	be	VBN
cord-016293-pyb00pt5	562	13	a	a	DT
cord-016293-pyb00pt5	562	14	valuable	valuable	JJ
cord-016293-pyb00pt5	562	15	wellspring	wellspring	NN
cord-016293-pyb00pt5	562	16	of	of	IN
cord-016293-pyb00pt5	562	17	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	562	18	for	for	IN
cord-016293-pyb00pt5	562	19	centuries	century	NNS
cord-016293-pyb00pt5	562	20	.	.	.
cord-016293-pyb00pt5	563	1	During	during	IN
cord-016293-pyb00pt5	563	2	the	the	DT
cord-016293-pyb00pt5	563	3	nineties	ninety	NNS
cord-016293-pyb00pt5	563	4	,	,	,
cord-016293-pyb00pt5	563	5	however	however	RB
cord-016293-pyb00pt5	563	6	,	,	,
cord-016293-pyb00pt5	563	7	intensive	intensive	JJ
cord-016293-pyb00pt5	563	8	research	research	NN
cord-016293-pyb00pt5	563	9	has	have	VBZ
cord-016293-pyb00pt5	563	10	focused	focus	VBN
cord-016293-pyb00pt5	563	11	on	on	IN
cord-016293-pyb00pt5	563	12	expanding	expand	VBG
cord-016293-pyb00pt5	563	13	this	this	DT
cord-016293-pyb00pt5	563	14	source	source	NN
cord-016293-pyb00pt5	563	15	through	through	IN
cord-016293-pyb00pt5	563	16	rDNA	rdna	JJ
cord-016293-pyb00pt5	563	17	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	563	18	and	and	CC
cord-016293-pyb00pt5	563	19	essentially	essentially	RB
cord-016293-pyb00pt5	563	20	using	use	VBG
cord-016293-pyb00pt5	563	21	plants	plant	NNS
cord-016293-pyb00pt5	563	22	and	and	CC
cord-016293-pyb00pt5	563	23	animals	animal	NNS
cord-016293-pyb00pt5	563	24	as	as	IN
cord-016293-pyb00pt5	563	25	living	live	VBG
cord-016293-pyb00pt5	563	26	factories	factory	NNS
cord-016293-pyb00pt5	563	27	for	for	IN
cord-016293-pyb00pt5	563	28	the	the	DT
cord-016293-pyb00pt5	563	29	commercial	commercial	JJ
cord-016293-pyb00pt5	563	30	production	production	NN
cord-016293-pyb00pt5	563	31	of	of	IN
cord-016293-pyb00pt5	563	32	vaccines	vaccine	NNS
cord-016293-pyb00pt5	563	33	,	,	,
cord-016293-pyb00pt5	563	34	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	563	35	and	and	CC
cord-016293-pyb00pt5	563	36	other	other	JJ
cord-016293-pyb00pt5	563	37	valuable	valuable	JJ
cord-016293-pyb00pt5	563	38	products	product	NNS
cord-016293-pyb00pt5	563	39	such	such	JJ
cord-016293-pyb00pt5	563	40	as	as	IN
cord-016293-pyb00pt5	563	41	industrial	industrial	JJ
cord-016293-pyb00pt5	563	42	enzymes	enzyme	NNS
cord-016293-pyb00pt5	563	43	and	and	CC
cord-016293-pyb00pt5	563	44	biosynthetic	biosynthetic	JJ
cord-016293-pyb00pt5	563	45	feedstocks	feedstock	NNS
cord-016293-pyb00pt5	563	46	.	.	.
cord-016293-pyb00pt5	564	1	Possibilities	possibility	NNS
cord-016293-pyb00pt5	564	2	in	in	IN
cord-016293-pyb00pt5	564	3	the	the	DT
cord-016293-pyb00pt5	564	4	medical	medical	JJ
cord-016293-pyb00pt5	564	5	field	field	NN
cord-016293-pyb00pt5	564	6	include	include	VBP
cord-016293-pyb00pt5	564	7	a	a	DT
cord-016293-pyb00pt5	564	8	wide	wide	JJ
cord-016293-pyb00pt5	564	9	variety	variety	NN
cord-016293-pyb00pt5	564	10	of	of	IN
cord-016293-pyb00pt5	564	11	compounds	compound	NNS
cord-016293-pyb00pt5	564	12	,	,	,
cord-016293-pyb00pt5	564	13	ranging	range	VBG
cord-016293-pyb00pt5	564	14	from	from	IN
cord-016293-pyb00pt5	564	15	edible	edible	JJ
cord-016293-pyb00pt5	564	16	vaccine	vaccine	NN
cord-016293-pyb00pt5	564	17	antigens	antigen	NNS
cord-016293-pyb00pt5	564	18	against	against	IN
cord-016293-pyb00pt5	564	19	hepatitis	hepatitis	NNP
cord-016293-pyb00pt5	564	20	B	B	NNP
cord-016293-pyb00pt5	564	21	and	and	CC
cord-016293-pyb00pt5	564	22	Norwalk	Norwalk	NNP
cord-016293-pyb00pt5	564	23	viruses	virus	NNS
cord-016293-pyb00pt5	564	24	(	(	-LRB-
cord-016293-pyb00pt5	564	25	Arntzen	Arntzen	NNP
cord-016293-pyb00pt5	564	26	,	,	,
cord-016293-pyb00pt5	564	27	1997	1997	CD
cord-016293-pyb00pt5	564	28	)	)	-RRB-
cord-016293-pyb00pt5	564	29	and	and	CC
cord-016293-pyb00pt5	564	30	Pseudomonas	Pseudomonas	NNP
cord-016293-pyb00pt5	564	31	aeruginosa	aeruginosa	NN
cord-016293-pyb00pt5	564	32	and	and	CC
cord-016293-pyb00pt5	564	33	Staphylococcus	Staphylococcus	NNP
cord-016293-pyb00pt5	564	34	aureus	aureus	NN
cord-016293-pyb00pt5	564	35	to	to	IN
cord-016293-pyb00pt5	564	36	vaccines	vaccine	NNS
cord-016293-pyb00pt5	564	37	against	against	IN
cord-016293-pyb00pt5	564	38	cancer	cancer	NN
cord-016293-pyb00pt5	564	39	and	and	CC
cord-016293-pyb00pt5	564	40	diabetes	diabetes	NN
cord-016293-pyb00pt5	564	41	,	,	,
cord-016293-pyb00pt5	564	42	enzymes	enzyme	NNS
cord-016293-pyb00pt5	564	43	,	,	,
cord-016293-pyb00pt5	564	44	hormones	hormone	NNS
cord-016293-pyb00pt5	564	45	,	,	,
cord-016293-pyb00pt5	564	46	cytokines	cytokine	NNS
cord-016293-pyb00pt5	564	47	,	,	,
cord-016293-pyb00pt5	564	48	interleukins	interleukin	NNS
cord-016293-pyb00pt5	564	49	,	,	,
cord-016293-pyb00pt5	564	50	plasma	plasma	NN
cord-016293-pyb00pt5	564	51	proteins	protein	NNS
cord-016293-pyb00pt5	564	52	,	,	,
cord-016293-pyb00pt5	564	53	and	and	CC
cord-016293-pyb00pt5	564	54	human	human	JJ
cord-016293-pyb00pt5	564	55	alpha-1-antitrypsin	alpha-1-antitrypsin	NNP
cord-016293-pyb00pt5	564	56	.	.	.
cord-016293-pyb00pt5	565	1	Thus	thus	RB
cord-016293-pyb00pt5	565	2	,	,	,
cord-016293-pyb00pt5	565	3	plant	plant	NN
cord-016293-pyb00pt5	565	4	cells	cell	NNS
cord-016293-pyb00pt5	565	5	are	be	VBP
cord-016293-pyb00pt5	565	6	capable	capable	JJ
cord-016293-pyb00pt5	565	7	of	of	IN
cord-016293-pyb00pt5	565	8	expressing	express	VBG
cord-016293-pyb00pt5	565	9	a	a	DT
cord-016293-pyb00pt5	565	10	large	large	JJ
cord-016293-pyb00pt5	565	11	variety	variety	NN
cord-016293-pyb00pt5	565	12	of	of	IN
cord-016293-pyb00pt5	565	13	recombinant	recombinant	JJ
cord-016293-pyb00pt5	565	14	proteins	protein	NNS
cord-016293-pyb00pt5	565	15	and	and	CC
cord-016293-pyb00pt5	565	16	protein	protein	NN
cord-016293-pyb00pt5	565	17	complexes	complex	NNS
cord-016293-pyb00pt5	565	18	.	.	.
cord-016293-pyb00pt5	566	1	Therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	566	2	produced	produce	VBN
cord-016293-pyb00pt5	566	3	in	in	IN
cord-016293-pyb00pt5	566	4	this	this	DT
cord-016293-pyb00pt5	566	5	way	way	NN
cord-016293-pyb00pt5	566	6	are	be	VBP
cord-016293-pyb00pt5	566	7	termed	term	VBN
cord-016293-pyb00pt5	566	8	plant	plant	NN
cord-016293-pyb00pt5	566	9	made	make	VBD
cord-016293-pyb00pt5	566	10	pharmaceuticals	pharmaceutical	NNS
cord-016293-pyb00pt5	566	11	(	(	-LRB-
cord-016293-pyb00pt5	566	12	PMPs	PMPs	NNP
cord-016293-pyb00pt5	566	13	)	)	-RRB-
cord-016293-pyb00pt5	566	14	.	.	.
cord-016293-pyb00pt5	567	1	And	and	CC
cord-016293-pyb00pt5	567	2	non	non	JJ
cord-016293-pyb00pt5	567	3	-	-	NNS
cord-016293-pyb00pt5	567	4	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	567	5	are	be	VBP
cord-016293-pyb00pt5	567	6	termed	term	VBN
cord-016293-pyb00pt5	567	7	plant	plant	NN
cord-016293-pyb00pt5	567	8	made	make	VBD
cord-016293-pyb00pt5	567	9	industrial	industrial	JJ
cord-016293-pyb00pt5	567	10	products	product	NNS
cord-016293-pyb00pt5	567	11	(	(	-LRB-
cord-016293-pyb00pt5	567	12	PMIPs	pmip	NNS
cord-016293-pyb00pt5	567	13	)	)	-RRB-
cord-016293-pyb00pt5	568	1	(	(	-LRB-
cord-016293-pyb00pt5	568	2	Newell	Newell	NNP
cord-016293-pyb00pt5	568	3	-	-	HYPH
cord-016293-pyb00pt5	568	4	McGloughlin	McGloughlin	NNP
cord-016293-pyb00pt5	568	5	,	,	,
cord-016293-pyb00pt5	568	6	2006	2006	CD
cord-016293-pyb00pt5	568	7	)	)	-RRB-
cord-016293-pyb00pt5	568	8	.	.	.
cord-016293-pyb00pt5	569	1	The	the	DT
cord-016293-pyb00pt5	569	2	first	first	JJ
cord-016293-pyb00pt5	569	3	reported	report	VBN
cord-016293-pyb00pt5	569	4	results	result	NNS
cord-016293-pyb00pt5	569	5	of	of	IN
cord-016293-pyb00pt5	569	6	successful	successful	JJ
cord-016293-pyb00pt5	569	7	human	human	JJ
cord-016293-pyb00pt5	569	8	clinical	clinical	JJ
cord-016293-pyb00pt5	569	9	trials	trial	NNS
cord-016293-pyb00pt5	569	10	with	with	IN
cord-016293-pyb00pt5	569	11	their	-PRON-	PRP$
cord-016293-pyb00pt5	569	12	transgenic	transgenic	JJ
cord-016293-pyb00pt5	569	13	plant	plant	NN
cord-016293-pyb00pt5	569	14	-	-	HYPH
cord-016293-pyb00pt5	569	15	derived	derive	VBN
cord-016293-pyb00pt5	569	16	pharmaceuticals	pharmaceutical	NNS
cord-016293-pyb00pt5	569	17	were	be	VBD
cord-016293-pyb00pt5	569	18	published	publish	VBN
cord-016293-pyb00pt5	569	19	in	in	IN
cord-016293-pyb00pt5	569	20	1998	1998	CD
cord-016293-pyb00pt5	569	21	.	.	.
cord-016293-pyb00pt5	570	1	They	-PRON-	PRP
cord-016293-pyb00pt5	570	2	were	be	VBD
cord-016293-pyb00pt5	570	3	an	an	DT
cord-016293-pyb00pt5	570	4	edible	edible	JJ
cord-016293-pyb00pt5	570	5	vaccine	vaccine	NN
cord-016293-pyb00pt5	570	6	against	against	IN
cord-016293-pyb00pt5	570	7	E.	E.	NNP
cord-016293-pyb00pt5	570	8	coli	coli	NNS
cord-016293-pyb00pt5	570	9	-	-	HYPH
cord-016293-pyb00pt5	570	10	induced	induce	VBN
cord-016293-pyb00pt5	570	11	diarrhea	diarrhea	NN
cord-016293-pyb00pt5	570	12	and	and	CC
cord-016293-pyb00pt5	570	13	a	a	DT
cord-016293-pyb00pt5	570	14	secretory	secretory	JJ
cord-016293-pyb00pt5	570	15	monoclonal	monoclonal	JJ
cord-016293-pyb00pt5	570	16	antibody	antibody	NN
cord-016293-pyb00pt5	570	17	directed	direct	VBN
cord-016293-pyb00pt5	570	18	against	against	IN
cord-016293-pyb00pt5	570	19	Streptococcus	streptococcus	NN
cord-016293-pyb00pt5	570	20	mutans	mutan	NNS
cord-016293-pyb00pt5	570	21	,	,	,
cord-016293-pyb00pt5	570	22	for	for	IN
cord-016293-pyb00pt5	570	23	preventative	preventative	JJ
cord-016293-pyb00pt5	570	24	immunotherapy	immunotherapy	NN
cord-016293-pyb00pt5	570	25	to	to	TO
cord-016293-pyb00pt5	570	26	reduce	reduce	VB
cord-016293-pyb00pt5	570	27	incidence	incidence	NN
cord-016293-pyb00pt5	570	28	of	of	IN
cord-016293-pyb00pt5	570	29	dental	dental	JJ
cord-016293-pyb00pt5	570	30	caries	carie	NNS
cord-016293-pyb00pt5	570	31	.	.	.
cord-016293-pyb00pt5	571	1	Haq	Haq	NNP
cord-016293-pyb00pt5	571	2	et	et	NNP
cord-016293-pyb00pt5	571	3	al	al	NNP
cord-016293-pyb00pt5	571	4	.	.	.
cord-016293-pyb00pt5	572	1	(	(	-LRB-
cord-016293-pyb00pt5	572	2	1995	1995	CD
cord-016293-pyb00pt5	572	3	)	)	-RRB-
cord-016293-pyb00pt5	572	4	reported	report	VBD
cord-016293-pyb00pt5	572	5	the	the	DT
cord-016293-pyb00pt5	572	6	expression	expression	NN
cord-016293-pyb00pt5	572	7	in	in	IN
cord-016293-pyb00pt5	572	8	potato	potato	NN
cord-016293-pyb00pt5	572	9	plants	plant	NNS
cord-016293-pyb00pt5	572	10	of	of	IN
cord-016293-pyb00pt5	572	11	a	a	DT
cord-016293-pyb00pt5	572	12	vaccine	vaccine	NN
cord-016293-pyb00pt5	572	13	against	against	IN
cord-016293-pyb00pt5	572	14	E.	E.	NNP
cord-016293-pyb00pt5	572	15	coli	coli	NNS
cord-016293-pyb00pt5	572	16	enterotoxin	enterotoxin	NNP
cord-016293-pyb00pt5	572	17	(	(	-LRB-
cord-016293-pyb00pt5	572	18	ETEC	ETEC	NNP
cord-016293-pyb00pt5	572	19	)	)	-RRB-
cord-016293-pyb00pt5	572	20	that	that	WDT
cord-016293-pyb00pt5	572	21	provided	provide	VBD
cord-016293-pyb00pt5	572	22	an	an	DT
cord-016293-pyb00pt5	572	23	immune	immune	JJ
cord-016293-pyb00pt5	572	24	response	response	NN
cord-016293-pyb00pt5	572	25	against	against	IN
cord-016293-pyb00pt5	572	26	the	the	DT
cord-016293-pyb00pt5	572	27	toxin	toxin	NN
cord-016293-pyb00pt5	572	28	in	in	IN
cord-016293-pyb00pt5	572	29	mice	mouse	NNS
cord-016293-pyb00pt5	572	30	.	.	.
cord-016293-pyb00pt5	573	1	Human	human	JJ
cord-016293-pyb00pt5	573	2	clinical	clinical	JJ
cord-016293-pyb00pt5	573	3	trials	trial	NNS
cord-016293-pyb00pt5	573	4	suggest	suggest	VBP
cord-016293-pyb00pt5	573	5	that	that	IN
cord-016293-pyb00pt5	573	6	oral	oral	JJ
cord-016293-pyb00pt5	573	7	vaccination	vaccination	NN
cord-016293-pyb00pt5	573	8	against	against	IN
cord-016293-pyb00pt5	573	9	either	either	DT
cord-016293-pyb00pt5	573	10	of	of	IN
cord-016293-pyb00pt5	573	11	the	the	DT
cord-016293-pyb00pt5	573	12	closely	closely	RB
cord-016293-pyb00pt5	573	13	related	related	JJ
cord-016293-pyb00pt5	573	14	enterotoxins	enterotoxin	NNS
cord-016293-pyb00pt5	573	15	of	of	IN
cord-016293-pyb00pt5	573	16	Vibrio	Vibrio	NNP
cord-016293-pyb00pt5	573	17	cholerae	cholerae	NN
cord-016293-pyb00pt5	573	18	and	and	CC
cord-016293-pyb00pt5	573	19	E.	E.	NNP
cord-016293-pyb00pt5	573	20	coli	coli	NNS
cord-016293-pyb00pt5	573	21	induces	induce	VBZ
cord-016293-pyb00pt5	573	22	production	production	NN
cord-016293-pyb00pt5	573	23	of	of	IN
cord-016293-pyb00pt5	573	24	antibodies	antibody	NNS
cord-016293-pyb00pt5	573	25	that	that	WDT
cord-016293-pyb00pt5	573	26	can	can	MD
cord-016293-pyb00pt5	573	27	neutralize	neutralize	VB
cord-016293-pyb00pt5	573	28	the	the	DT
cord-016293-pyb00pt5	573	29	respective	respective	JJ
cord-016293-pyb00pt5	573	30	toxins	toxin	NNS
cord-016293-pyb00pt5	573	31	by	by	IN
cord-016293-pyb00pt5	573	32	preventing	prevent	VBG
cord-016293-pyb00pt5	573	33	them	-PRON-	PRP
cord-016293-pyb00pt5	573	34	from	from	IN
cord-016293-pyb00pt5	573	35	binding	bind	VBG
cord-016293-pyb00pt5	573	36	to	to	IN
cord-016293-pyb00pt5	573	37	gut	gut	NN
cord-016293-pyb00pt5	573	38	cells	cell	NNS
cord-016293-pyb00pt5	573	39	.	.	.
cord-016293-pyb00pt5	574	1	Similar	similar	JJ
cord-016293-pyb00pt5	574	2	results	result	NNS
cord-016293-pyb00pt5	574	3	were	be	VBD
cord-016293-pyb00pt5	574	4	found	find	VBN
cord-016293-pyb00pt5	574	5	for	for	IN
cord-016293-pyb00pt5	574	6	Norwalk	Norwalk	NNP
cord-016293-pyb00pt5	574	7	virus	virus	NN
cord-016293-pyb00pt5	574	8	oral	oral	JJ
cord-016293-pyb00pt5	574	9	vaccines	vaccine	NNS
cord-016293-pyb00pt5	574	10	in	in	IN
cord-016293-pyb00pt5	574	11	potatoes	potato	NNS
cord-016293-pyb00pt5	574	12	.	.	.
cord-016293-pyb00pt5	575	1	For	for	IN
cord-016293-pyb00pt5	575	2	developing	develop	VBG
cord-016293-pyb00pt5	575	3	countries	country	NNS
cord-016293-pyb00pt5	575	4	,	,	,
cord-016293-pyb00pt5	575	5	the	the	DT
cord-016293-pyb00pt5	575	6	intention	intention	NN
cord-016293-pyb00pt5	575	7	is	be	VBZ
cord-016293-pyb00pt5	575	8	to	to	TO
cord-016293-pyb00pt5	575	9	deliver	deliver	VB
cord-016293-pyb00pt5	575	10	them	-PRON-	PRP
cord-016293-pyb00pt5	575	11	in	in	IN
cord-016293-pyb00pt5	575	12	bananas	banana	NNS
cord-016293-pyb00pt5	575	13	or	or	CC
cord-016293-pyb00pt5	575	14	tomatoes	tomato	NNS
cord-016293-pyb00pt5	576	1	(	(	-LRB-
cord-016293-pyb00pt5	576	2	Newell	Newell	NNP
cord-016293-pyb00pt5	576	3	-	-	HYPH
cord-016293-pyb00pt5	576	4	McGloughlin	McGloughlin	NNP
cord-016293-pyb00pt5	576	5	,	,	,
cord-016293-pyb00pt5	576	6	2006	2006	CD
cord-016293-pyb00pt5	576	7	)	)	-RRB-
cord-016293-pyb00pt5	576	8	.	.	.
cord-016293-pyb00pt5	577	1	Plants	plant	NNS
cord-016293-pyb00pt5	577	2	are	be	VBP
cord-016293-pyb00pt5	577	3	also	also	RB
cord-016293-pyb00pt5	577	4	faster	fast	JJR
cord-016293-pyb00pt5	577	5	,	,	,
cord-016293-pyb00pt5	577	6	cheaper	cheap	JJR
cord-016293-pyb00pt5	577	7	,	,	,
cord-016293-pyb00pt5	577	8	more	more	RBR
cord-016293-pyb00pt5	577	9	convenient	convenient	JJ
cord-016293-pyb00pt5	577	10	and	and	CC
cord-016293-pyb00pt5	577	11	more	more	RBR
cord-016293-pyb00pt5	577	12	efficient	efficient	JJ
cord-016293-pyb00pt5	577	13	than	than	IN
cord-016293-pyb00pt5	577	14	the	the	DT
cord-016293-pyb00pt5	577	15	principal	principal	JJ
cord-016293-pyb00pt5	577	16	eukaryotic	eukaryotic	JJ
cord-016293-pyb00pt5	577	17	production	production	NN
cord-016293-pyb00pt5	577	18	system	system	NN
cord-016293-pyb00pt5	577	19	,	,	,
cord-016293-pyb00pt5	577	20	namely	namely	RB
cord-016293-pyb00pt5	577	21	Chinese	chinese	JJ
cord-016293-pyb00pt5	577	22	Hamster	Hamster	NNP
cord-016293-pyb00pt5	577	23	Ovary	Ovary	NNP
cord-016293-pyb00pt5	577	24	(	(	-LRB-
cord-016293-pyb00pt5	577	25	CHO	CHO	NNP
cord-016293-pyb00pt5	577	26	)	)	-RRB-
cord-016293-pyb00pt5	577	27	cells	cell	NNS
cord-016293-pyb00pt5	577	28	for	for	IN
cord-016293-pyb00pt5	577	29	the	the	DT
cord-016293-pyb00pt5	577	30	production	production	NN
cord-016293-pyb00pt5	577	31	of	of	IN
cord-016293-pyb00pt5	577	32	pharmaceuticals	pharmaceutical	NNS
cord-016293-pyb00pt5	577	33	.	.	.
cord-016293-pyb00pt5	578	1	Hundreds	hundred	NNS
cord-016293-pyb00pt5	578	2	of	of	IN
cord-016293-pyb00pt5	578	3	acres	acre	NNS
cord-016293-pyb00pt5	578	4	of	of	IN
cord-016293-pyb00pt5	578	5	protein	protein	NN
cord-016293-pyb00pt5	578	6	-	-	HYPH
cord-016293-pyb00pt5	578	7	containing	contain	VBG
cord-016293-pyb00pt5	578	8	seeds	seed	NNS
cord-016293-pyb00pt5	578	9	could	could	MD
cord-016293-pyb00pt5	578	10	inexpensively	inexpensively	RB
cord-016293-pyb00pt5	578	11	double	double	VB
cord-016293-pyb00pt5	578	12	the	the	DT
cord-016293-pyb00pt5	578	13	production	production	NN
cord-016293-pyb00pt5	578	14	of	of	IN
cord-016293-pyb00pt5	578	15	a	a	DT
cord-016293-pyb00pt5	578	16	CHO	CHO	NNP
cord-016293-pyb00pt5	578	17	bioreactor	bioreactor	NN
cord-016293-pyb00pt5	578	18	factory	factory	NN
cord-016293-pyb00pt5	578	19	.	.	.
cord-016293-pyb00pt5	579	1	In	in	IN
cord-016293-pyb00pt5	579	2	addition	addition	NN
cord-016293-pyb00pt5	579	3	,	,	,
cord-016293-pyb00pt5	579	4	proteins	protein	NNS
cord-016293-pyb00pt5	579	5	can	can	MD
cord-016293-pyb00pt5	579	6	be	be	VB
cord-016293-pyb00pt5	579	7	expressed	express	VBN
cord-016293-pyb00pt5	579	8	at	at	IN
cord-016293-pyb00pt5	579	9	the	the	DT
cord-016293-pyb00pt5	579	10	highest	high	JJS
cord-016293-pyb00pt5	579	11	levels	level	NNS
cord-016293-pyb00pt5	579	12	in	in	IN
cord-016293-pyb00pt5	579	13	the	the	DT
cord-016293-pyb00pt5	579	14	harvestable	harvestable	JJ
cord-016293-pyb00pt5	579	15	seed	seed	NN
cord-016293-pyb00pt5	579	16	and	and	CC
cord-016293-pyb00pt5	579	17	plant	plant	NN
cord-016293-pyb00pt5	579	18	-	-	HYPH
cord-016293-pyb00pt5	579	19	made	make	VBN
cord-016293-pyb00pt5	579	20	proteins	protein	NNS
cord-016293-pyb00pt5	579	21	and	and	CC
cord-016293-pyb00pt5	579	22	enzymes	enzyme	NNS
cord-016293-pyb00pt5	579	23	formulated	formulate	VBN
cord-016293-pyb00pt5	579	24	in	in	IN
cord-016293-pyb00pt5	579	25	seeds	seed	NNS
cord-016293-pyb00pt5	579	26	have	have	VBP
cord-016293-pyb00pt5	579	27	been	be	VBN
cord-016293-pyb00pt5	579	28	found	find	VBN
cord-016293-pyb00pt5	579	29	to	to	TO
cord-016293-pyb00pt5	579	30	be	be	VB
cord-016293-pyb00pt5	579	31	extremely	extremely	RB
cord-016293-pyb00pt5	579	32	stable	stable	JJ
cord-016293-pyb00pt5	579	33	,	,	,
cord-016293-pyb00pt5	579	34	reducing	reduce	VBG
cord-016293-pyb00pt5	579	35	storage	storage	NN
cord-016293-pyb00pt5	579	36	and	and	CC
cord-016293-pyb00pt5	579	37	shipping	shipping	NN
cord-016293-pyb00pt5	579	38	costs	cost	NNS
cord-016293-pyb00pt5	579	39	.	.	.
cord-016293-pyb00pt5	580	1	Pharming	Pharming	NNP
cord-016293-pyb00pt5	580	2	may	may	MD
cord-016293-pyb00pt5	580	3	also	also	RB
cord-016293-pyb00pt5	580	4	enable	enable	VB
cord-016293-pyb00pt5	580	5	research	research	NN
cord-016293-pyb00pt5	580	6	on	on	IN
cord-016293-pyb00pt5	580	7	drugs	drug	NNS
cord-016293-pyb00pt5	580	8	that	that	WDT
cord-016293-pyb00pt5	580	9	can	can	MD
cord-016293-pyb00pt5	580	10	not	not	RB
cord-016293-pyb00pt5	580	11	currently	currently	RB
cord-016293-pyb00pt5	580	12	be	be	VB
cord-016293-pyb00pt5	580	13	produced	produce	VBN
cord-016293-pyb00pt5	580	14	.	.	.
cord-016293-pyb00pt5	581	1	For	for	IN
cord-016293-pyb00pt5	581	2	example	example	NN
cord-016293-pyb00pt5	581	3	,	,	,
cord-016293-pyb00pt5	581	4	CropTech	CropTech	NNP
cord-016293-pyb00pt5	581	5	in	in	IN
cord-016293-pyb00pt5	581	6	Blacksburg	Blacksburg	NNP
cord-016293-pyb00pt5	581	7	,	,	,
cord-016293-pyb00pt5	581	8	Va.	Virginia	NNP
cord-016293-pyb00pt5	581	9	,	,	,
cord-016293-pyb00pt5	581	10	is	be	VBZ
cord-016293-pyb00pt5	581	11	investigating	investigate	VBG
cord-016293-pyb00pt5	581	12	a	a	DT
cord-016293-pyb00pt5	581	13	protein	protein	NN
cord-016293-pyb00pt5	581	14	that	that	WDT
cord-016293-pyb00pt5	581	15	seems	seem	VBZ
cord-016293-pyb00pt5	581	16	to	to	TO
cord-016293-pyb00pt5	581	17	be	be	VB
cord-016293-pyb00pt5	581	18	a	a	DT
cord-016293-pyb00pt5	581	19	very	very	RB
cord-016293-pyb00pt5	581	20	effective	effective	JJ
cord-016293-pyb00pt5	581	21	anticancer	anticancer	JJ
cord-016293-pyb00pt5	581	22	agent	agent	NN
cord-016293-pyb00pt5	581	23	.	.	.
cord-016293-pyb00pt5	582	1	The	the	DT
cord-016293-pyb00pt5	582	2	problem	problem	NN
cord-016293-pyb00pt5	582	3	is	be	VBZ
cord-016293-pyb00pt5	582	4	that	that	IN
cord-016293-pyb00pt5	582	5	this	this	DT
cord-016293-pyb00pt5	582	6	protein	protein	NN
cord-016293-pyb00pt5	582	7	is	be	VBZ
cord-016293-pyb00pt5	582	8	difficult	difficult	JJ
cord-016293-pyb00pt5	582	9	to	to	TO
cord-016293-pyb00pt5	582	10	produce	produce	VB
cord-016293-pyb00pt5	582	11	in	in	IN
cord-016293-pyb00pt5	582	12	mammalian	mammalian	JJ
cord-016293-pyb00pt5	582	13	cell	cell	NN
cord-016293-pyb00pt5	582	14	culture	culture	NN
cord-016293-pyb00pt5	582	15	systems	system	NNS
cord-016293-pyb00pt5	582	16	as	as	IN
cord-016293-pyb00pt5	582	17	it	-PRON-	PRP
cord-016293-pyb00pt5	582	18	inhibits	inhibit	VBZ
cord-016293-pyb00pt5	582	19	cell	cell	NN
cord-016293-pyb00pt5	582	20	growth	growth	NN
cord-016293-pyb00pt5	582	21	.	.	.
cord-016293-pyb00pt5	583	1	This	this	DT
cord-016293-pyb00pt5	583	2	should	should	MD
cord-016293-pyb00pt5	583	3	not	not	RB
cord-016293-pyb00pt5	583	4	be	be	VB
cord-016293-pyb00pt5	583	5	a	a	DT
cord-016293-pyb00pt5	583	6	problem	problem	NN
cord-016293-pyb00pt5	583	7	in	in	IN
cord-016293-pyb00pt5	583	8	plants	plant	NNS
cord-016293-pyb00pt5	583	9	.	.	.
cord-016293-pyb00pt5	584	1	Furthermore	furthermore	RB
cord-016293-pyb00pt5	584	2	,	,	,
cord-016293-pyb00pt5	584	3	production	production	NN
cord-016293-pyb00pt5	584	4	size	size	NN
cord-016293-pyb00pt5	584	5	is	be	VBZ
cord-016293-pyb00pt5	584	6	flexible	flexible	JJ
cord-016293-pyb00pt5	584	7	and	and	CC
cord-016293-pyb00pt5	584	8	easily	easily	RB
cord-016293-pyb00pt5	584	9	adjustable	adjustable	JJ
cord-016293-pyb00pt5	584	10	to	to	IN
cord-016293-pyb00pt5	584	11	the	the	DT
cord-016293-pyb00pt5	584	12	needs	need	NNS
cord-016293-pyb00pt5	584	13	of	of	IN
cord-016293-pyb00pt5	584	14	changing	change	VBG
cord-016293-pyb00pt5	584	15	markets	market	NNS
cord-016293-pyb00pt5	584	16	.	.	.
cord-016293-pyb00pt5	585	1	Making	make	VBG
cord-016293-pyb00pt5	585	2	pharmaceuticals	pharmaceutical	NNS
cord-016293-pyb00pt5	585	3	from	from	IN
cord-016293-pyb00pt5	585	4	plants	plant	NNS
cord-016293-pyb00pt5	585	5	is	be	VBZ
cord-016293-pyb00pt5	585	6	also	also	RB
cord-016293-pyb00pt5	585	7	a	a	DT
cord-016293-pyb00pt5	585	8	sustainable	sustainable	JJ
cord-016293-pyb00pt5	585	9	process	process	NN
cord-016293-pyb00pt5	585	10	,	,	,
cord-016293-pyb00pt5	585	11	because	because	IN
cord-016293-pyb00pt5	585	12	the	the	DT
cord-016293-pyb00pt5	585	13	plants	plant	NNS
cord-016293-pyb00pt5	585	14	and	and	CC
cord-016293-pyb00pt5	585	15	crops	crop	NNS
cord-016293-pyb00pt5	585	16	used	use	VBN
cord-016293-pyb00pt5	585	17	as	as	IN
cord-016293-pyb00pt5	585	18	raw	raw	JJ
cord-016293-pyb00pt5	585	19	materials	material	NNS
cord-016293-pyb00pt5	585	20	are	be	VBP
cord-016293-pyb00pt5	585	21	renewable	renewable	JJ
cord-016293-pyb00pt5	585	22	.	.	.
cord-016293-pyb00pt5	586	1	The	the	DT
cord-016293-pyb00pt5	586	2	system	system	NN
cord-016293-pyb00pt5	586	3	also	also	RB
cord-016293-pyb00pt5	586	4	has	have	VBZ
cord-016293-pyb00pt5	586	5	the	the	DT
cord-016293-pyb00pt5	586	6	potential	potential	NN
cord-016293-pyb00pt5	586	7	to	to	TO
cord-016293-pyb00pt5	586	8	address	address	VB
cord-016293-pyb00pt5	586	9	problems	problem	NNS
cord-016293-pyb00pt5	586	10	associated	associate	VBN
cord-016293-pyb00pt5	586	11	with	with	IN
cord-016293-pyb00pt5	586	12	provision	provision	NN
cord-016293-pyb00pt5	586	13	of	of	IN
cord-016293-pyb00pt5	586	14	vaccines	vaccine	NNS
cord-016293-pyb00pt5	586	15	to	to	IN
cord-016293-pyb00pt5	586	16	people	people	NNS
cord-016293-pyb00pt5	586	17	in	in	IN
cord-016293-pyb00pt5	586	18	developing	develop	VBG
cord-016293-pyb00pt5	586	19	countries	country	NNS
cord-016293-pyb00pt5	586	20	.	.	.
cord-016293-pyb00pt5	587	1	Products	product	NNS
cord-016293-pyb00pt5	587	2	from	from	IN
cord-016293-pyb00pt5	587	3	these	these	DT
cord-016293-pyb00pt5	587	4	alternative	alternative	JJ
cord-016293-pyb00pt5	587	5	sources	source	NNS
cord-016293-pyb00pt5	587	6	do	do	VBP
cord-016293-pyb00pt5	587	7	not	not	RB
cord-016293-pyb00pt5	587	8	require	require	VB
cord-016293-pyb00pt5	587	9	a	a	DT
cord-016293-pyb00pt5	587	10	so	so	RB
cord-016293-pyb00pt5	587	11	-	-	HYPH
cord-016293-pyb00pt5	587	12	called	call	VBN
cord-016293-pyb00pt5	587	13	"	"	``
cord-016293-pyb00pt5	587	14	cold	cold	JJ
cord-016293-pyb00pt5	587	15	chain	chain	NN
cord-016293-pyb00pt5	587	16	"	"	''
cord-016293-pyb00pt5	587	17	for	for	IN
cord-016293-pyb00pt5	587	18	refrigerated	refrigerated	JJ
cord-016293-pyb00pt5	587	19	transport	transport	NN
cord-016293-pyb00pt5	587	20	and	and	CC
cord-016293-pyb00pt5	587	21	storage	storage	NN
cord-016293-pyb00pt5	587	22	.	.	.
cord-016293-pyb00pt5	588	1	Those	those	DT
cord-016293-pyb00pt5	588	2	being	be	VBG
cord-016293-pyb00pt5	588	3	developed	develop	VBN
cord-016293-pyb00pt5	588	4	for	for	IN
cord-016293-pyb00pt5	588	5	oral	oral	JJ
cord-016293-pyb00pt5	588	6	delivery	delivery	NN
cord-016293-pyb00pt5	588	7	obviates	obviate	VBZ
cord-016293-pyb00pt5	588	8	the	the	DT
cord-016293-pyb00pt5	588	9	need	need	NN
cord-016293-pyb00pt5	588	10	for	for	IN
cord-016293-pyb00pt5	588	11	needles	needle	NNS
cord-016293-pyb00pt5	588	12	and	and	CC
cord-016293-pyb00pt5	588	13	aspectic	aspectic	JJ
cord-016293-pyb00pt5	588	14	conditions	condition	NNS
cord-016293-pyb00pt5	588	15	which	which	WDT
cord-016293-pyb00pt5	588	16	often	often	RB
cord-016293-pyb00pt5	588	17	are	be	VBP
cord-016293-pyb00pt5	588	18	a	a	DT
cord-016293-pyb00pt5	588	19	problem	problem	NN
cord-016293-pyb00pt5	588	20	in	in	IN
cord-016293-pyb00pt5	588	21	those	those	DT
cord-016293-pyb00pt5	588	22	areas	area	NNS
cord-016293-pyb00pt5	588	23	.	.	.
cord-016293-pyb00pt5	589	1	Apart	apart	RB
cord-016293-pyb00pt5	589	2	from	from	IN
cord-016293-pyb00pt5	589	3	those	those	DT
cord-016293-pyb00pt5	589	4	specific	specific	JJ
cord-016293-pyb00pt5	589	5	applications	application	NNS
cord-016293-pyb00pt5	589	6	where	where	WRB
cord-016293-pyb00pt5	589	7	the	the	DT
cord-016293-pyb00pt5	589	8	plant	plant	NN
cord-016293-pyb00pt5	589	9	system	system	NN
cord-016293-pyb00pt5	589	10	is	be	VBZ
cord-016293-pyb00pt5	589	11	optimum	optimum	JJ
cord-016293-pyb00pt5	589	12	there	there	EX
cord-016293-pyb00pt5	589	13	are	be	VBP
cord-016293-pyb00pt5	589	14	many	many	JJ
cord-016293-pyb00pt5	589	15	other	other	JJ
cord-016293-pyb00pt5	589	16	advantages	advantage	NNS
cord-016293-pyb00pt5	589	17	to	to	IN
cord-016293-pyb00pt5	589	18	using	use	VBG
cord-016293-pyb00pt5	589	19	plant	plant	NN
cord-016293-pyb00pt5	589	20	production	production	NN
cord-016293-pyb00pt5	589	21	.	.	.
cord-016293-pyb00pt5	590	1	Many	many	JJ
cord-016293-pyb00pt5	590	2	new	new	JJ
cord-016293-pyb00pt5	590	3	pharmaceuticals	pharmaceutical	NNS
cord-016293-pyb00pt5	590	4	based	base	VBN
cord-016293-pyb00pt5	590	5	on	on	IN
cord-016293-pyb00pt5	590	6	recombinant	recombinant	JJ
cord-016293-pyb00pt5	590	7	proteins	protein	NNS
cord-016293-pyb00pt5	590	8	will	will	MD
cord-016293-pyb00pt5	590	9	receive	receive	VB
cord-016293-pyb00pt5	590	10	regulatory	regulatory	JJ
cord-016293-pyb00pt5	590	11	approval	approval	NN
cord-016293-pyb00pt5	590	12	from	from	IN
cord-016293-pyb00pt5	590	13	the	the	DT
cord-016293-pyb00pt5	590	14	United	United	NNP
cord-016293-pyb00pt5	590	15	States	States	NNP
cord-016293-pyb00pt5	590	16	Food	Food	NNP
cord-016293-pyb00pt5	590	17	and	and	CC
cord-016293-pyb00pt5	590	18	Drug	Drug	NNP
cord-016293-pyb00pt5	590	19	Administration	Administration	NNP
cord-016293-pyb00pt5	590	20	(	(	-LRB-
cord-016293-pyb00pt5	590	21	FDA	FDA	NNP
cord-016293-pyb00pt5	590	22	)	)	-RRB-
cord-016293-pyb00pt5	590	23	in	in	IN
cord-016293-pyb00pt5	590	24	the	the	DT
cord-016293-pyb00pt5	590	25	next	next	JJ
cord-016293-pyb00pt5	590	26	few	few	JJ
cord-016293-pyb00pt5	590	27	years	year	NNS
cord-016293-pyb00pt5	590	28	.	.	.
cord-016293-pyb00pt5	591	1	As	as	IN
cord-016293-pyb00pt5	591	2	these	these	DT
cord-016293-pyb00pt5	591	3	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	591	4	make	make	VBP
cord-016293-pyb00pt5	591	5	their	-PRON-	PRP$
cord-016293-pyb00pt5	591	6	way	way	NN
cord-016293-pyb00pt5	591	7	through	through	IN
cord-016293-pyb00pt5	591	8	clinical	clinical	JJ
cord-016293-pyb00pt5	591	9	trials	trial	NNS
cord-016293-pyb00pt5	591	10	and	and	CC
cord-016293-pyb00pt5	591	11	evaluation	evaluation	NN
cord-016293-pyb00pt5	591	12	,	,	,
cord-016293-pyb00pt5	591	13	the	the	DT
cord-016293-pyb00pt5	591	14	pharmaceutical	pharmaceutical	NN
cord-016293-pyb00pt5	591	15	industry	industry	NN
cord-016293-pyb00pt5	591	16	faces	face	VBZ
cord-016293-pyb00pt5	591	17	a	a	DT
cord-016293-pyb00pt5	591	18	production	production	NN
cord-016293-pyb00pt5	591	19	capacity	capacity	NN
cord-016293-pyb00pt5	591	20	challenge	challenge	NN
cord-016293-pyb00pt5	591	21	.	.	.
cord-016293-pyb00pt5	592	1	Pharmaceutical	pharmaceutical	JJ
cord-016293-pyb00pt5	592	2	discovery	discovery	NN
cord-016293-pyb00pt5	592	3	companies	company	NNS
cord-016293-pyb00pt5	592	4	are	be	VBP
cord-016293-pyb00pt5	592	5	exploring	explore	VBG
cord-016293-pyb00pt5	592	6	plant	plant	NN
cord-016293-pyb00pt5	592	7	-	-	HYPH
cord-016293-pyb00pt5	592	8	based	base	VBN
cord-016293-pyb00pt5	592	9	production	production	NN
cord-016293-pyb00pt5	592	10	to	to	TO
cord-016293-pyb00pt5	592	11	overcome	overcome	VB
cord-016293-pyb00pt5	592	12	capacity	capacity	NN
cord-016293-pyb00pt5	592	13	limitations	limitation	NNS
cord-016293-pyb00pt5	592	14	,	,	,
cord-016293-pyb00pt5	592	15	enable	enable	VB
cord-016293-pyb00pt5	592	16	production	production	NN
cord-016293-pyb00pt5	592	17	of	of	IN
cord-016293-pyb00pt5	592	18	complex	complex	JJ
cord-016293-pyb00pt5	592	19	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	592	20	proteins	protein	NNS
cord-016293-pyb00pt5	592	21	,	,	,
cord-016293-pyb00pt5	592	22	and	and	CC
cord-016293-pyb00pt5	592	23	fully	fully	RB
cord-016293-pyb00pt5	592	24	realize	realize	VB
cord-016293-pyb00pt5	592	25	the	the	DT
cord-016293-pyb00pt5	592	26	commercial	commercial	JJ
cord-016293-pyb00pt5	592	27	potential	potential	NN
cord-016293-pyb00pt5	592	28	of	of	IN
cord-016293-pyb00pt5	592	29	their	-PRON-	PRP$
cord-016293-pyb00pt5	592	30	biopharmaceuticals	biopharmaceutical	NNS
cord-016293-pyb00pt5	592	31	(	(	-LRB-
cord-016293-pyb00pt5	592	32	Newell	Newell	NNP
cord-016293-pyb00pt5	592	33	-	-	HYPH
cord-016293-pyb00pt5	592	34	McGloughlin	McGloughlin	NNP
cord-016293-pyb00pt5	592	35	,	,	,
cord-016293-pyb00pt5	592	36	2006	2006	CD
cord-016293-pyb00pt5	592	37	)	)	-RRB-
cord-016293-pyb00pt5	592	38	.	.	.
cord-016293-pyb00pt5	593	1	Nineteen	nineteen	CD
cord-016293-pyb00pt5	593	2	ninety	ninety	CD
cord-016293-pyb00pt5	593	3	also	also	RB
cord-016293-pyb00pt5	593	4	marked	mark	VBD
cord-016293-pyb00pt5	593	5	a	a	DT
cord-016293-pyb00pt5	593	6	major	major	JJ
cord-016293-pyb00pt5	593	7	milestone	milestone	NN
cord-016293-pyb00pt5	593	8	in	in	IN
cord-016293-pyb00pt5	593	9	the	the	DT
cord-016293-pyb00pt5	593	10	animal	animal	NN
cord-016293-pyb00pt5	593	11	biotech	biotech	NN
cord-016293-pyb00pt5	593	12	world	world	NN
cord-016293-pyb00pt5	593	13	when	when	WRB
cord-016293-pyb00pt5	593	14	Herman	Herman	NNP
cord-016293-pyb00pt5	593	15	made	make	VBD
cord-016293-pyb00pt5	593	16	his	-PRON-	PRP$
cord-016293-pyb00pt5	593	17	appearance	appearance	NN
cord-016293-pyb00pt5	593	18	on	on	IN
cord-016293-pyb00pt5	593	19	the	the	DT
cord-016293-pyb00pt5	593	20	world	world	NN
cord-016293-pyb00pt5	593	21	's	's	POS
cord-016293-pyb00pt5	593	22	stage	stage	NN
cord-016293-pyb00pt5	593	23	.	.	.
cord-016293-pyb00pt5	594	1	Since	since	IN
cord-016293-pyb00pt5	594	2	the	the	DT
cord-016293-pyb00pt5	594	3	Palmiter	Palmiter	NNP
cord-016293-pyb00pt5	594	4	's	's	POS
cord-016293-pyb00pt5	594	5	mouse	mouse	NN
cord-016293-pyb00pt5	594	6	,	,	,
cord-016293-pyb00pt5	594	7	transgenic	transgenic	JJ
cord-016293-pyb00pt5	594	8	technology	technology	NN
cord-016293-pyb00pt5	594	9	has	have	VBZ
cord-016293-pyb00pt5	594	10	been	be	VBN
cord-016293-pyb00pt5	594	11	applied	apply	VBN
cord-016293-pyb00pt5	594	12	to	to	IN
cord-016293-pyb00pt5	594	13	several	several	JJ
cord-016293-pyb00pt5	594	14	species	specie	NNS
cord-016293-pyb00pt5	594	15	including	include	VBG
cord-016293-pyb00pt5	594	16	agricultural	agricultural	JJ
cord-016293-pyb00pt5	594	17	species	specie	NNS
cord-016293-pyb00pt5	594	18	such	such	JJ
cord-016293-pyb00pt5	594	19	as	as	IN
cord-016293-pyb00pt5	594	20	sheep	sheep	NN
cord-016293-pyb00pt5	594	21	,	,	,
cord-016293-pyb00pt5	594	22	cattle	cattle	NNS
cord-016293-pyb00pt5	594	23	,	,	,
cord-016293-pyb00pt5	594	24	goats	goat	NNS
cord-016293-pyb00pt5	594	25	,	,	,
cord-016293-pyb00pt5	594	26	pigs	pig	NNS
cord-016293-pyb00pt5	594	27	,	,	,
cord-016293-pyb00pt5	594	28	rabbits	rabbit	NNS
cord-016293-pyb00pt5	594	29	,	,	,
cord-016293-pyb00pt5	594	30	poultry	poultry	NN
cord-016293-pyb00pt5	594	31	,	,	,
cord-016293-pyb00pt5	594	32	and	and	CC
cord-016293-pyb00pt5	594	33	fish	fish	NN
cord-016293-pyb00pt5	594	34	.	.	.
cord-016293-pyb00pt5	595	1	Herman	Herman	NNP
cord-016293-pyb00pt5	595	2	was	be	VBD
cord-016293-pyb00pt5	595	3	the	the	DT
cord-016293-pyb00pt5	595	4	first	first	JJ
cord-016293-pyb00pt5	595	5	transgenic	transgenic	JJ
cord-016293-pyb00pt5	595	6	bovine	bovine	NN
cord-016293-pyb00pt5	595	7	created	create	VBN
cord-016293-pyb00pt5	595	8	by	by	IN
cord-016293-pyb00pt5	595	9	GenPharm	GenPharm	NNP
cord-016293-pyb00pt5	595	10	International	International	NNP
cord-016293-pyb00pt5	595	11	,	,	,
cord-016293-pyb00pt5	595	12	Inc.	Inc.	NNP
cord-016293-pyb00pt5	595	13	,	,	,
cord-016293-pyb00pt5	595	14	in	in	IN
cord-016293-pyb00pt5	595	15	a	a	DT
cord-016293-pyb00pt5	595	16	laboratory	laboratory	NN
cord-016293-pyb00pt5	595	17	in	in	IN
cord-016293-pyb00pt5	595	18	the	the	DT
cord-016293-pyb00pt5	595	19	Netherlands	Netherlands	NNP
cord-016293-pyb00pt5	595	20	at	at	IN
cord-016293-pyb00pt5	595	21	the	the	DT
cord-016293-pyb00pt5	595	22	early	early	JJ
cord-016293-pyb00pt5	595	23	embryo	embryo	NN
cord-016293-pyb00pt5	595	24	stage	stage	NN
cord-016293-pyb00pt5	595	25	.	.	.
cord-016293-pyb00pt5	596	1	Scientist	Scientist	NNP
cord-016293-pyb00pt5	596	2	's	's	POS
cord-016293-pyb00pt5	596	3	microinjected	microinjecte	VBN
cord-016293-pyb00pt5	596	4	recently	recently	RB
cord-016293-pyb00pt5	596	5	fertilized	fertilize	VBN
cord-016293-pyb00pt5	596	6	eggs	egg	NNS
cord-016293-pyb00pt5	596	7	with	with	IN
cord-016293-pyb00pt5	596	8	the	the	DT
cord-016293-pyb00pt5	596	9	gene	gene	NN
cord-016293-pyb00pt5	596	10	coding	code	VBG
cord-016293-pyb00pt5	596	11	for	for	IN
cord-016293-pyb00pt5	596	12	human	human	JJ
cord-016293-pyb00pt5	596	13	lactoferrin	lactoferrin	NNP
cord-016293-pyb00pt5	596	14	.	.	.
cord-016293-pyb00pt5	597	1	The	the	DT
cord-016293-pyb00pt5	597	2	scientists	scientist	NNS
cord-016293-pyb00pt5	597	3	then	then	RB
cord-016293-pyb00pt5	597	4	cultured	culture	VBD
cord-016293-pyb00pt5	597	5	the	the	DT
cord-016293-pyb00pt5	597	6	cells	cell	NNS
cord-016293-pyb00pt5	597	7	in	in	IN
cord-016293-pyb00pt5	597	8	vitro	vitro	FW
cord-016293-pyb00pt5	597	9	to	to	IN
cord-016293-pyb00pt5	597	10	the	the	DT
cord-016293-pyb00pt5	597	11	embryo	embryo	NN
cord-016293-pyb00pt5	597	12	stage	stage	NN
cord-016293-pyb00pt5	597	13	and	and	CC
cord-016293-pyb00pt5	597	14	transferred	transfer	VBD
cord-016293-pyb00pt5	597	15	them	-PRON-	PRP
cord-016293-pyb00pt5	597	16	to	to	IN
cord-016293-pyb00pt5	597	17	recipient	recipient	NN
cord-016293-pyb00pt5	597	18	cattle	cattle	NNS
cord-016293-pyb00pt5	597	19	.	.	.
cord-016293-pyb00pt5	598	1	Lactoferrin	Lactoferrin	NNP
cord-016293-pyb00pt5	598	2	,	,	,
cord-016293-pyb00pt5	598	3	an	an	DT
cord-016293-pyb00pt5	598	4	iron	iron	NN
cord-016293-pyb00pt5	598	5	-	-	HYPH
cord-016293-pyb00pt5	598	6	containing	contain	VBG
cord-016293-pyb00pt5	598	7	anti	anti	JJ
cord-016293-pyb00pt5	598	8	-	-	JJ
cord-016293-pyb00pt5	598	9	bacterial	bacterial	JJ
cord-016293-pyb00pt5	598	10	protein	protein	NN
cord-016293-pyb00pt5	598	11	is	be	VBZ
cord-016293-pyb00pt5	598	12	essential	essential	JJ
cord-016293-pyb00pt5	598	13	for	for	IN
cord-016293-pyb00pt5	598	14	infant	infant	JJ
cord-016293-pyb00pt5	598	15	growth	growth	NN
cord-016293-pyb00pt5	598	16	.	.	.
cord-016293-pyb00pt5	599	1	Since	since	IN
cord-016293-pyb00pt5	599	2	cow	cow	NN
cord-016293-pyb00pt5	599	3	's	's	POS
cord-016293-pyb00pt5	599	4	milk	milk	NN
cord-016293-pyb00pt5	599	5	does	do	VBZ
cord-016293-pyb00pt5	599	6	n't	not	RB
cord-016293-pyb00pt5	599	7	contain	contain	VB
cord-016293-pyb00pt5	599	8	lactoferrin	lactoferrin	NNS
cord-016293-pyb00pt5	599	9	,	,	,
cord-016293-pyb00pt5	599	10	infants	infant	NNS
cord-016293-pyb00pt5	599	11	must	must	MD
cord-016293-pyb00pt5	599	12	be	be	VB
cord-016293-pyb00pt5	599	13	fed	feed	VBN
cord-016293-pyb00pt5	599	14	from	from	IN
cord-016293-pyb00pt5	599	15	other	other	JJ
cord-016293-pyb00pt5	599	16	sources	source	NNS
cord-016293-pyb00pt5	599	17	that	that	WDT
cord-016293-pyb00pt5	599	18	are	be	VBP
cord-016293-pyb00pt5	599	19	rich	rich	JJ
cord-016293-pyb00pt5	599	20	in	in	IN
cord-016293-pyb00pt5	599	21	iron	iron	NN
cord-016293-pyb00pt5	599	22	-formula	-formula	NN
cord-016293-pyb00pt5	599	23	or	or	CC
cord-016293-pyb00pt5	599	24	mother	mother	NN
cord-016293-pyb00pt5	599	25	's	's	POS
cord-016293-pyb00pt5	599	26	milk	milk	NN
cord-016293-pyb00pt5	599	27	(	(	-LRB-
cord-016293-pyb00pt5	599	28	Newell	Newell	NNP
cord-016293-pyb00pt5	599	29	-	-	HYPH
cord-016293-pyb00pt5	599	30	McGloughlin	McGloughlin	NNP
cord-016293-pyb00pt5	599	31	,	,	,
cord-016293-pyb00pt5	599	32	2001	2001	CD
cord-016293-pyb00pt5	599	33	)	)	-RRB-
cord-016293-pyb00pt5	599	34	.	.	.
cord-016293-pyb00pt5	600	1	As	as	IN
cord-016293-pyb00pt5	600	2	Herman	Herman	NNP
cord-016293-pyb00pt5	600	3	was	be	VBD
cord-016293-pyb00pt5	600	4	a	a	DT
cord-016293-pyb00pt5	600	5	boy	boy	NN
cord-016293-pyb00pt5	600	6	he	-PRON-	PRP
cord-016293-pyb00pt5	600	7	would	would	MD
cord-016293-pyb00pt5	600	8	be	be	VB
cord-016293-pyb00pt5	600	9	unable	unable	JJ
cord-016293-pyb00pt5	600	10	to	to	TO
cord-016293-pyb00pt5	600	11	provide	provide	VB
cord-016293-pyb00pt5	600	12	the	the	DT
cord-016293-pyb00pt5	600	13	source	source	NN
cord-016293-pyb00pt5	600	14	,	,	,
cord-016293-pyb00pt5	600	15	that	that	WDT
cord-016293-pyb00pt5	600	16	would	would	MD
cord-016293-pyb00pt5	600	17	require	require	VB
cord-016293-pyb00pt5	600	18	the	the	DT
cord-016293-pyb00pt5	600	19	production	production	NN
cord-016293-pyb00pt5	600	20	of	of	IN
cord-016293-pyb00pt5	600	21	daughters	daughter	NNS
cord-016293-pyb00pt5	600	22	which	which	WDT
cord-016293-pyb00pt5	600	23	was	be	VBD
cord-016293-pyb00pt5	600	24	not	not	RB
cord-016293-pyb00pt5	600	25	necessarily	necessarily	RB
cord-016293-pyb00pt5	600	26	a	a	DT
cord-016293-pyb00pt5	600	27	straightforward	straightforward	JJ
cord-016293-pyb00pt5	600	28	process	process	NN
cord-016293-pyb00pt5	600	29	.	.	.
cord-016293-pyb00pt5	601	1	The	the	DT
cord-016293-pyb00pt5	601	2	Dutch	dutch	JJ
cord-016293-pyb00pt5	601	3	parliments	parliment	NNS
cord-016293-pyb00pt5	601	4	permission	permission	NN
cord-016293-pyb00pt5	601	5	was	be	VBD
cord-016293-pyb00pt5	601	6	required	require	VBN
cord-016293-pyb00pt5	601	7	.	.	.
cord-016293-pyb00pt5	602	1	In	in	IN
cord-016293-pyb00pt5	602	2	1992	1992	CD
cord-016293-pyb00pt5	602	3	they	-PRON-	PRP
cord-016293-pyb00pt5	602	4	finally	finally	RB
cord-016293-pyb00pt5	602	5	approved	approve	VBD
cord-016293-pyb00pt5	602	6	a	a	DT
cord-016293-pyb00pt5	602	7	measure	measure	NN
cord-016293-pyb00pt5	602	8	that	that	WDT
cord-016293-pyb00pt5	602	9	permitted	permit	VBD
cord-016293-pyb00pt5	602	10	the	the	DT
cord-016293-pyb00pt5	602	11	world	world	NN
cord-016293-pyb00pt5	602	12	's	's	POS
cord-016293-pyb00pt5	602	13	first	first	JJ
cord-016293-pyb00pt5	602	14	genetically	genetically	RB
cord-016293-pyb00pt5	602	15	engineered	engineer	VBN
cord-016293-pyb00pt5	602	16	bull	bull	NN
cord-016293-pyb00pt5	602	17	to	to	TO
cord-016293-pyb00pt5	602	18	reproduce	reproduce	VB
cord-016293-pyb00pt5	602	19	.	.	.
cord-016293-pyb00pt5	603	1	The	the	DT
cord-016293-pyb00pt5	603	2	Leiden	Leiden	NNP
cord-016293-pyb00pt5	603	3	-	-	HYPH
cord-016293-pyb00pt5	603	4	based	base	VBN
cord-016293-pyb00pt5	603	5	Gene	Gene	NNP
cord-016293-pyb00pt5	603	6	Pharming	Pharming	NNP
cord-016293-pyb00pt5	603	7	proceeded	proceed	VBD
cord-016293-pyb00pt5	603	8	to	to	TO
cord-016293-pyb00pt5	603	9	artificially	artificially	RB
cord-016293-pyb00pt5	603	10	inseminate	inseminate	VB
cord-016293-pyb00pt5	603	11	60	60	CD
cord-016293-pyb00pt5	603	12	cows	cow	NNS
cord-016293-pyb00pt5	603	13	with	with	IN
cord-016293-pyb00pt5	603	14	Herman	Herman	NNP
cord-016293-pyb00pt5	603	15	's	's	POS
cord-016293-pyb00pt5	603	16	sperm	sperm	NN
cord-016293-pyb00pt5	603	17	.	.	.
cord-016293-pyb00pt5	604	1	With	with	IN
cord-016293-pyb00pt5	604	2	a	a	DT
cord-016293-pyb00pt5	604	3	promise	promise	NN
cord-016293-pyb00pt5	604	4	that	that	WDT
cord-016293-pyb00pt5	604	5	the	the	DT
cord-016293-pyb00pt5	604	6	protein	protein	NN
cord-016293-pyb00pt5	604	7	,	,	,
cord-016293-pyb00pt5	604	8	lactoferrin	lactoferrin	NNP
cord-016293-pyb00pt5	604	9	,	,	,
cord-016293-pyb00pt5	604	10	would	would	MD
cord-016293-pyb00pt5	604	11	be	be	VB
cord-016293-pyb00pt5	604	12	the	the	DT
cord-016293-pyb00pt5	604	13	first	first	JJ
cord-016293-pyb00pt5	604	14	in	in	IN
cord-016293-pyb00pt5	604	15	a	a	DT
cord-016293-pyb00pt5	604	16	new	new	JJ
cord-016293-pyb00pt5	604	17	generation	generation	NN
cord-016293-pyb00pt5	604	18	of	of	IN
cord-016293-pyb00pt5	604	19	inexpensive	inexpensive	JJ
cord-016293-pyb00pt5	604	20	,	,	,
cord-016293-pyb00pt5	604	21	high	high	JJ
cord-016293-pyb00pt5	604	22	-	-	HYPH
cord-016293-pyb00pt5	604	23	tech	tech	NN
cord-016293-pyb00pt5	604	24	drugs	drug	NNS
cord-016293-pyb00pt5	604	25	derived	derive	VBN
cord-016293-pyb00pt5	604	26	from	from	IN
cord-016293-pyb00pt5	604	27	cows	cow	NNS
cord-016293-pyb00pt5	604	28	'	'	POS
cord-016293-pyb00pt5	604	29	milk	milk	NN
cord-016293-pyb00pt5	604	30	to	to	TO
cord-016293-pyb00pt5	604	31	treat	treat	VB
cord-016293-pyb00pt5	604	32	complex	complex	JJ
cord-016293-pyb00pt5	604	33	diseases	disease	NNS
cord-016293-pyb00pt5	604	34	like	like	IN
cord-016293-pyb00pt5	604	35	AIDS	AIDS	NNP
cord-016293-pyb00pt5	604	36	and	and	CC
cord-016293-pyb00pt5	604	37	cancer	cancer	NN
cord-016293-pyb00pt5	604	38	.	.	.
cord-016293-pyb00pt5	605	1	Herman	Herman	NNP
cord-016293-pyb00pt5	605	2	,	,	,
cord-016293-pyb00pt5	605	3	became	become	VBD
cord-016293-pyb00pt5	605	4	the	the	DT
cord-016293-pyb00pt5	605	5	father	father	NN
cord-016293-pyb00pt5	605	6	of	of	IN
cord-016293-pyb00pt5	605	7	at	at	RB
cord-016293-pyb00pt5	605	8	least	least	RBS
cord-016293-pyb00pt5	605	9	eight	eight	CD
cord-016293-pyb00pt5	605	10	female	female	JJ
cord-016293-pyb00pt5	605	11	calves	calf	NNS
cord-016293-pyb00pt5	605	12	in	in	IN
cord-016293-pyb00pt5	605	13	1994	1994	CD
cord-016293-pyb00pt5	605	14	,	,	,
cord-016293-pyb00pt5	605	15	and	and	CC
cord-016293-pyb00pt5	605	16	each	each	DT
cord-016293-pyb00pt5	605	17	one	one	NN
cord-016293-pyb00pt5	605	18	inherited	inherit	VBD
cord-016293-pyb00pt5	605	19	the	the	DT
cord-016293-pyb00pt5	605	20	gene	gene	NN
cord-016293-pyb00pt5	605	21	for	for	IN
cord-016293-pyb00pt5	605	22	lactoferrin	lactoferrin	NNP
cord-016293-pyb00pt5	605	23	production	production	NN
cord-016293-pyb00pt5	605	24	.	.	.
cord-016293-pyb00pt5	606	1	While	while	IN
cord-016293-pyb00pt5	606	2	their	-PRON-	PRP$
cord-016293-pyb00pt5	606	3	birth	birth	NN
cord-016293-pyb00pt5	606	4	was	be	VBD
cord-016293-pyb00pt5	606	5	initially	initially	RB
cord-016293-pyb00pt5	606	6	greeted	greet	VBN
cord-016293-pyb00pt5	606	7	as	as	IN
cord-016293-pyb00pt5	606	8	a	a	DT
cord-016293-pyb00pt5	606	9	scientific	scientific	JJ
cord-016293-pyb00pt5	606	10	advancement	advancement	NN
cord-016293-pyb00pt5	606	11	that	that	WDT
cord-016293-pyb00pt5	606	12	could	could	MD
cord-016293-pyb00pt5	606	13	have	have	VB
cord-016293-pyb00pt5	606	14	far	far	RB
cord-016293-pyb00pt5	606	15	-	-	HYPH
cord-016293-pyb00pt5	606	16	reaching	reach	VBG
cord-016293-pyb00pt5	606	17	effects	effect	NNS
cord-016293-pyb00pt5	606	18	for	for	IN
cord-016293-pyb00pt5	606	19	children	child	NNS
cord-016293-pyb00pt5	606	20	in	in	IN
cord-016293-pyb00pt5	606	21	developing	develop	VBG
cord-016293-pyb00pt5	606	22	nations	nation	NNS
cord-016293-pyb00pt5	606	23	,	,	,
cord-016293-pyb00pt5	606	24	the	the	DT
cord-016293-pyb00pt5	606	25	levels	level	NNS
cord-016293-pyb00pt5	606	26	of	of	IN
cord-016293-pyb00pt5	606	27	expression	expression	NN
cord-016293-pyb00pt5	606	28	were	be	VBD
cord-016293-pyb00pt5	606	29	too	too	RB
cord-016293-pyb00pt5	606	30	low	low	JJ
cord-016293-pyb00pt5	606	31	to	to	TO
cord-016293-pyb00pt5	606	32	be	be	VB
cord-016293-pyb00pt5	606	33	commercially	commercially	RB
cord-016293-pyb00pt5	606	34	viable	viable	JJ
cord-016293-pyb00pt5	606	35	.	.	.
cord-016293-pyb00pt5	607	1	By	by	IN
cord-016293-pyb00pt5	607	2	2002	2002	CD
cord-016293-pyb00pt5	607	3	,	,	,
cord-016293-pyb00pt5	607	4	Herman	Herman	NNP
cord-016293-pyb00pt5	607	5	,	,	,
cord-016293-pyb00pt5	607	6	who	who	WP
cord-016293-pyb00pt5	607	7	likes	like	VBZ
cord-016293-pyb00pt5	607	8	to	to	TO
cord-016293-pyb00pt5	607	9	listen	listen	VB
cord-016293-pyb00pt5	607	10	to	to	IN
cord-016293-pyb00pt5	607	11	rap	rap	NN
cord-016293-pyb00pt5	607	12	music	music	NN
cord-016293-pyb00pt5	607	13	to	to	TO
cord-016293-pyb00pt5	607	14	relax	relax	VB
cord-016293-pyb00pt5	607	15	,	,	,
cord-016293-pyb00pt5	607	16	had	have	VBD
cord-016293-pyb00pt5	607	17	sired	sire	VBN
cord-016293-pyb00pt5	607	18	55	55	CD
cord-016293-pyb00pt5	607	19	calves	calf	NNS
cord-016293-pyb00pt5	607	20	and	and	CC
cord-016293-pyb00pt5	607	21	outlived	outlive	VBD
cord-016293-pyb00pt5	607	22	them	-PRON-	PRP
cord-016293-pyb00pt5	607	23	all	all	DT
cord-016293-pyb00pt5	607	24	.	.	.
cord-016293-pyb00pt5	608	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	608	2	offspring	offspring	NN
cord-016293-pyb00pt5	608	3	were	be	VBD
cord-016293-pyb00pt5	608	4	all	all	DT
cord-016293-pyb00pt5	608	5	killed	kill	VBN
cord-016293-pyb00pt5	608	6	and	and	CC
cord-016293-pyb00pt5	608	7	destroyed	destroy	VBN
cord-016293-pyb00pt5	608	8	after	after	IN
cord-016293-pyb00pt5	608	9	the	the	DT
cord-016293-pyb00pt5	608	10	end	end	NN
cord-016293-pyb00pt5	608	11	of	of	IN
cord-016293-pyb00pt5	608	12	the	the	DT
cord-016293-pyb00pt5	608	13	experiment	experiment	NN
cord-016293-pyb00pt5	608	14	,	,	,
cord-016293-pyb00pt5	608	15	in	in	IN
cord-016293-pyb00pt5	608	16	line	line	NN
cord-016293-pyb00pt5	608	17	with	with	IN
cord-016293-pyb00pt5	608	18	Dutch	dutch	JJ
cord-016293-pyb00pt5	608	19	health	health	NN
cord-016293-pyb00pt5	608	20	legislation	legislation	NN
cord-016293-pyb00pt5	608	21	.	.	.
cord-016293-pyb00pt5	609	1	Herman	Herman	NNP
cord-016293-pyb00pt5	609	2	was	be	VBD
cord-016293-pyb00pt5	609	3	also	also	RB
cord-016293-pyb00pt5	609	4	slated	slate	VBN
cord-016293-pyb00pt5	609	5	for	for	IN
cord-016293-pyb00pt5	609	6	the	the	DT
cord-016293-pyb00pt5	609	7	abattoir	abattoir	NN
cord-016293-pyb00pt5	609	8	,	,	,
cord-016293-pyb00pt5	609	9	but	but	CC
cord-016293-pyb00pt5	609	10	the	the	DT
cord-016293-pyb00pt5	609	11	Dutch	dutch	JJ
cord-016293-pyb00pt5	609	12	public	public	NN
cord-016293-pyb00pt5	609	13	-proud	-proud	$
cord-016293-pyb00pt5	609	14	of	of	IN
cord-016293-pyb00pt5	609	15	making	make	VBG
cord-016293-pyb00pt5	609	16	history	history	NN
cord-016293-pyb00pt5	609	17	with	with	IN
cord-016293-pyb00pt5	609	18	Herman	Herman	NNP
cord-016293-pyb00pt5	609	19	-rose	-rose	VBD
cord-016293-pyb00pt5	609	20	up	up	RP
cord-016293-pyb00pt5	609	21	in	in	IN
cord-016293-pyb00pt5	609	22	protest	protest	NN
cord-016293-pyb00pt5	609	23	,	,	,
cord-016293-pyb00pt5	609	24	especially	especially	RB
cord-016293-pyb00pt5	609	25	after	after	IN
cord-016293-pyb00pt5	609	26	a	a	DT
cord-016293-pyb00pt5	609	27	television	television	NN
cord-016293-pyb00pt5	609	28	program	program	NN
cord-016293-pyb00pt5	609	29	screened	screen	VBD
cord-016293-pyb00pt5	609	30	footage	footage	NN
cord-016293-pyb00pt5	609	31	showing	show	VBG
cord-016293-pyb00pt5	609	32	the	the	DT
cord-016293-pyb00pt5	609	33	amiable	amiable	JJ
cord-016293-pyb00pt5	609	34	bull	bull	NN
cord-016293-pyb00pt5	609	35	licking	lick	VBG
cord-016293-pyb00pt5	609	36	a	a	DT
cord-016293-pyb00pt5	609	37	kitten	kitten	NN
cord-016293-pyb00pt5	609	38	.	.	.
cord-016293-pyb00pt5	610	1	Herman	Herman	NNP
cord-016293-pyb00pt5	610	2	won	win	VBD
cord-016293-pyb00pt5	610	3	a	a	DT
cord-016293-pyb00pt5	610	4	bill	bill	NN
cord-016293-pyb00pt5	610	5	of	of	IN
cord-016293-pyb00pt5	610	6	clemency	clemency	NN
cord-016293-pyb00pt5	610	7	from	from	IN
cord-016293-pyb00pt5	610	8	parliament	parliament	NN
cord-016293-pyb00pt5	610	9	.	.	.
cord-016293-pyb00pt5	611	1	However	however	RB
cord-016293-pyb00pt5	611	2	,	,	,
cord-016293-pyb00pt5	611	3	instead	instead	RB
cord-016293-pyb00pt5	611	4	of	of	IN
cord-016293-pyb00pt5	611	5	retirement	retirement	NN
cord-016293-pyb00pt5	611	6	on	on	IN
cord-016293-pyb00pt5	611	7	a	a	DT
cord-016293-pyb00pt5	611	8	comfortable	comfortable	JJ
cord-016293-pyb00pt5	611	9	bed	bed	NN
cord-016293-pyb00pt5	611	10	of	of	IN
cord-016293-pyb00pt5	611	11	straw	straw	NN
cord-016293-pyb00pt5	611	12	,	,	,
cord-016293-pyb00pt5	611	13	listening	listen	VBG
cord-016293-pyb00pt5	611	14	to	to	IN
cord-016293-pyb00pt5	611	15	rap	rap	NN
cord-016293-pyb00pt5	611	16	music	music	NN
cord-016293-pyb00pt5	611	17	,	,	,
cord-016293-pyb00pt5	611	18	Herman	Herman	NNP
cord-016293-pyb00pt5	611	19	was	be	VBD
cord-016293-pyb00pt5	611	20	pressed	press	VBN
cord-016293-pyb00pt5	611	21	into	into	IN
cord-016293-pyb00pt5	611	22	service	service	NN
cord-016293-pyb00pt5	611	23	again	again	RB
cord-016293-pyb00pt5	611	24	.	.	.
cord-016293-pyb00pt5	612	1	He	-PRON-	PRP
cord-016293-pyb00pt5	612	2	now	now	RB
cord-016293-pyb00pt5	612	3	stars	star	VBZ
cord-016293-pyb00pt5	612	4	at	at	IN
cord-016293-pyb00pt5	612	5	a	a	DT
cord-016293-pyb00pt5	612	6	permanent	permanent	JJ
cord-016293-pyb00pt5	612	7	biotech	biotech	JJ
cord-016293-pyb00pt5	612	8	exhibit	exhibit	NN
cord-016293-pyb00pt5	612	9	in	in	IN
cord-016293-pyb00pt5	612	10	Naturalis	Naturalis	NNP
cord-016293-pyb00pt5	612	11	,	,	,
cord-016293-pyb00pt5	612	12	a	a	DT
cord-016293-pyb00pt5	612	13	natural	natural	JJ
cord-016293-pyb00pt5	612	14	history	history	NN
cord-016293-pyb00pt5	612	15	museum	museum	NN
cord-016293-pyb00pt5	612	16	in	in	IN
cord-016293-pyb00pt5	612	17	the	the	DT
cord-016293-pyb00pt5	612	18	Dutch	dutch	JJ
cord-016293-pyb00pt5	612	19	city	city	NN
cord-016293-pyb00pt5	612	20	of	of	IN
cord-016293-pyb00pt5	612	21	Leiden	Leiden	NNP
cord-016293-pyb00pt5	612	22	.	.	.
cord-016293-pyb00pt5	613	1	After	after	IN
cord-016293-pyb00pt5	613	2	his	-PRON-	PRP$
cord-016293-pyb00pt5	613	3	death	death	NN
cord-016293-pyb00pt5	613	4	,	,	,
cord-016293-pyb00pt5	613	5	he	-PRON-	PRP
cord-016293-pyb00pt5	613	6	will	will	MD
cord-016293-pyb00pt5	613	7	be	be	VB
cord-016293-pyb00pt5	613	8	stuffed	stuff	VBN
cord-016293-pyb00pt5	613	9	and	and	CC
cord-016293-pyb00pt5	613	10	remain	remain	VB
cord-016293-pyb00pt5	613	11	in	in	IN
cord-016293-pyb00pt5	613	12	the	the	DT
cord-016293-pyb00pt5	613	13	museum	museum	NN
cord-016293-pyb00pt5	613	14	in	in	IN
cord-016293-pyb00pt5	613	15	perpetuity	perpetuity	NN
cord-016293-pyb00pt5	613	16	(	(	-LRB-
cord-016293-pyb00pt5	613	17	A	a	DT
cord-016293-pyb00pt5	613	18	fate	fate	NN
cord-016293-pyb00pt5	613	19	similar	similar	JJ
cord-016293-pyb00pt5	613	20	to	to	IN
cord-016293-pyb00pt5	613	21	what	what	WP
cord-016293-pyb00pt5	613	22	awaited	await	VBD
cord-016293-pyb00pt5	613	23	an	an	DT
cord-016293-pyb00pt5	613	24	even	even	RB
cord-016293-pyb00pt5	613	25	more	more	RBR
cord-016293-pyb00pt5	613	26	famous	famous	JJ
cord-016293-pyb00pt5	613	27	mammalian	mammalian	JJ
cord-016293-pyb00pt5	613	28	first	first	RB
cord-016293-pyb00pt5	613	29	born	bear	VBN
cord-016293-pyb00pt5	613	30	later	later	RB
cord-016293-pyb00pt5	613	31	in	in	IN
cord-016293-pyb00pt5	613	32	the	the	DT
cord-016293-pyb00pt5	613	33	decade	decade	NN
cord-016293-pyb00pt5	613	34	)	)	-RRB-
cord-016293-pyb00pt5	613	35	.	.	.
cord-016293-pyb00pt5	614	1	The	the	DT
cord-016293-pyb00pt5	614	2	applications	application	NNS
cord-016293-pyb00pt5	614	3	for	for	IN
cord-016293-pyb00pt5	614	4	transgenic	transgenic	JJ
cord-016293-pyb00pt5	614	5	animal	animal	NN
cord-016293-pyb00pt5	614	6	research	research	NN
cord-016293-pyb00pt5	614	7	fall	fall	VBP
cord-016293-pyb00pt5	614	8	broadly	broadly	RB
cord-016293-pyb00pt5	614	9	into	into	IN
cord-016293-pyb00pt5	614	10	two	two	CD
cord-016293-pyb00pt5	614	11	distinct	distinct	JJ
cord-016293-pyb00pt5	614	12	areas	area	NNS
cord-016293-pyb00pt5	614	13	,	,	,
cord-016293-pyb00pt5	614	14	namely	namely	RB
cord-016293-pyb00pt5	614	15	medical	medical	JJ
cord-016293-pyb00pt5	614	16	and	and	CC
cord-016293-pyb00pt5	614	17	agricultural	agricultural	JJ
cord-016293-pyb00pt5	614	18	applications	application	NNS
cord-016293-pyb00pt5	614	19	.	.	.
cord-016293-pyb00pt5	615	1	The	the	DT
cord-016293-pyb00pt5	615	2	recent	recent	JJ
cord-016293-pyb00pt5	615	3	focus	focus	NN
cord-016293-pyb00pt5	615	4	on	on	IN
cord-016293-pyb00pt5	615	5	developing	develop	VBG
cord-016293-pyb00pt5	615	6	animals	animal	NNS
cord-016293-pyb00pt5	615	7	as	as	IN
cord-016293-pyb00pt5	615	8	bioreactors	bioreactor	NNS
cord-016293-pyb00pt5	615	9	to	to	TO
cord-016293-pyb00pt5	615	10	produce	produce	VB
cord-016293-pyb00pt5	615	11	valuable	valuable	JJ
cord-016293-pyb00pt5	615	12	proteins	protein	NNS
cord-016293-pyb00pt5	615	13	in	in	IN
cord-016293-pyb00pt5	615	14	their	-PRON-	PRP$
cord-016293-pyb00pt5	615	15	milk	milk	NN
cord-016293-pyb00pt5	615	16	can	can	MD
cord-016293-pyb00pt5	615	17	be	be	VB
cord-016293-pyb00pt5	615	18	catalogued	catalogue	VBN
cord-016293-pyb00pt5	615	19	under	under	IN
cord-016293-pyb00pt5	615	20	both	both	DT
cord-016293-pyb00pt5	615	21	areas	area	NNS
cord-016293-pyb00pt5	615	22	.	.	.
cord-016293-pyb00pt5	616	1	Underlying	underlie	VBG
cord-016293-pyb00pt5	616	2	each	each	DT
cord-016293-pyb00pt5	616	3	of	of	IN
cord-016293-pyb00pt5	616	4	these	these	DT
cord-016293-pyb00pt5	616	5	,	,	,
cord-016293-pyb00pt5	616	6	of	of	IN
cord-016293-pyb00pt5	616	7	course	course	NN
cord-016293-pyb00pt5	616	8	,	,	,
cord-016293-pyb00pt5	616	9	is	be	VBZ
cord-016293-pyb00pt5	616	10	a	a	DT
cord-016293-pyb00pt5	616	11	more	more	RBR
cord-016293-pyb00pt5	616	12	fundamental	fundamental	JJ
cord-016293-pyb00pt5	616	13	application	application	NN
cord-016293-pyb00pt5	616	14	,	,	,
cord-016293-pyb00pt5	616	15	that	that	DT
cord-016293-pyb00pt5	616	16	is	be	VBZ
cord-016293-pyb00pt5	616	17	the	the	DT
cord-016293-pyb00pt5	616	18	use	use	NN
cord-016293-pyb00pt5	616	19	of	of	IN
cord-016293-pyb00pt5	616	20	those	those	DT
cord-016293-pyb00pt5	616	21	techniques	technique	NNS
cord-016293-pyb00pt5	616	22	as	as	IN
cord-016293-pyb00pt5	616	23	tools	tool	NNS
cord-016293-pyb00pt5	616	24	to	to	TO
cord-016293-pyb00pt5	616	25	ascertain	ascertain	VB
cord-016293-pyb00pt5	616	26	the	the	DT
cord-016293-pyb00pt5	616	27	molecular	molecular	JJ
cord-016293-pyb00pt5	616	28	and	and	CC
cord-016293-pyb00pt5	616	29	physiological	physiological	JJ
cord-016293-pyb00pt5	616	30	bases	basis	NNS
cord-016293-pyb00pt5	616	31	of	of	IN
cord-016293-pyb00pt5	616	32	gene	gene	NN
cord-016293-pyb00pt5	616	33	expression	expression	NN
cord-016293-pyb00pt5	616	34	and	and	CC
cord-016293-pyb00pt5	616	35	animal	animal	NN
cord-016293-pyb00pt5	616	36	development	development	NN
cord-016293-pyb00pt5	616	37	.	.	.
cord-016293-pyb00pt5	617	1	This	this	DT
cord-016293-pyb00pt5	617	2	understanding	understanding	NN
cord-016293-pyb00pt5	617	3	can	can	MD
cord-016293-pyb00pt5	617	4	then	then	RB
cord-016293-pyb00pt5	617	5	lead	lead	VB
cord-016293-pyb00pt5	617	6	to	to	IN
cord-016293-pyb00pt5	617	7	the	the	DT
cord-016293-pyb00pt5	617	8	creation	creation	NN
cord-016293-pyb00pt5	617	9	of	of	IN
cord-016293-pyb00pt5	617	10	techniques	technique	NNS
cord-016293-pyb00pt5	617	11	to	to	TO
cord-016293-pyb00pt5	617	12	modify	modify	VB
cord-016293-pyb00pt5	617	13	development	development	NN
cord-016293-pyb00pt5	617	14	pathways	pathway	NNS
cord-016293-pyb00pt5	617	15	.	.	.
cord-016293-pyb00pt5	618	1	In	in	IN
cord-016293-pyb00pt5	618	2	1992	1992	CD
cord-016293-pyb00pt5	618	3	a	a	DT
cord-016293-pyb00pt5	618	4	European	european	JJ
cord-016293-pyb00pt5	618	5	decision	decision	NN
cord-016293-pyb00pt5	618	6	with	with	IN
cord-016293-pyb00pt5	618	7	rather	rather	RB
cord-016293-pyb00pt5	618	8	more	more	RBR
cord-016293-pyb00pt5	618	9	far	far	RB
cord-016293-pyb00pt5	618	10	-	-	HYPH
cord-016293-pyb00pt5	618	11	reaching	reach	VBG
cord-016293-pyb00pt5	618	12	implications	implication	NNS
cord-016293-pyb00pt5	618	13	than	than	IN
cord-016293-pyb00pt5	618	14	Hermans	Hermans	NNP
cord-016293-pyb00pt5	618	15	sex	sex	NN
cord-016293-pyb00pt5	618	16	life	life	NN
cord-016293-pyb00pt5	618	17	was	be	VBD
cord-016293-pyb00pt5	618	18	made	make	VBN
cord-016293-pyb00pt5	618	19	.	.	.
cord-016293-pyb00pt5	619	1	The	the	DT
cord-016293-pyb00pt5	619	2	first	first	JJ
cord-016293-pyb00pt5	619	3	European	european	JJ
cord-016293-pyb00pt5	619	4	patent	patent	NN
cord-016293-pyb00pt5	619	5	on	on	IN
cord-016293-pyb00pt5	619	6	a	a	DT
cord-016293-pyb00pt5	619	7	transgenic	transgenic	JJ
cord-016293-pyb00pt5	619	8	animal	animal	NN
cord-016293-pyb00pt5	619	9	was	be	VBD
cord-016293-pyb00pt5	619	10	issued	issue	VBN
cord-016293-pyb00pt5	619	11	for	for	IN
cord-016293-pyb00pt5	619	12	a	a	DT
cord-016293-pyb00pt5	619	13	transgenic	transgenic	JJ
cord-016293-pyb00pt5	619	14	mouse	mouse	NN
cord-016293-pyb00pt5	619	15	sensitive	sensitive	JJ
cord-016293-pyb00pt5	619	16	to	to	IN
cord-016293-pyb00pt5	619	17	carcinogens	carcinogen	NNS
cord-016293-pyb00pt5	620	1	-Harvard	-Harvard	NNP
cord-016293-pyb00pt5	620	2	's	's	POS
cord-016293-pyb00pt5	620	3	"	"	``
cord-016293-pyb00pt5	620	4	Oncomouse	Oncomouse	NNP
cord-016293-pyb00pt5	620	5	"	"	''
cord-016293-pyb00pt5	620	6	.	.	.
cord-016293-pyb00pt5	621	1	The	the	DT
cord-016293-pyb00pt5	621	2	oncomouse	oncomouse	NNP
cord-016293-pyb00pt5	621	3	patent	patent	NN
cord-016293-pyb00pt5	621	4	application	application	NN
cord-016293-pyb00pt5	621	5	was	be	VBD
cord-016293-pyb00pt5	621	6	refused	refuse	VBN
cord-016293-pyb00pt5	621	7	in	in	IN
cord-016293-pyb00pt5	621	8	Europe	Europe	NNP
cord-016293-pyb00pt5	621	9	in	in	IN
cord-016293-pyb00pt5	621	10	1989	1989	CD
cord-016293-pyb00pt5	621	11	due	due	JJ
cord-016293-pyb00pt5	621	12	primarily	primarily	RB
cord-016293-pyb00pt5	621	13	to	to	IN
cord-016293-pyb00pt5	621	14	an	an	DT
cord-016293-pyb00pt5	621	15	established	establish	VBN
cord-016293-pyb00pt5	621	16	ban	ban	NN
cord-016293-pyb00pt5	621	17	on	on	IN
cord-016293-pyb00pt5	621	18	animal	animal	NN
cord-016293-pyb00pt5	621	19	patenting	patenting	NN
cord-016293-pyb00pt5	621	20	.	.	.
cord-016293-pyb00pt5	622	1	The	the	DT
cord-016293-pyb00pt5	622	2	application	application	NN
cord-016293-pyb00pt5	622	3	was	be	VBD
cord-016293-pyb00pt5	622	4	revised	revise	VBN
cord-016293-pyb00pt5	622	5	to	to	TO
cord-016293-pyb00pt5	622	6	make	make	VB
cord-016293-pyb00pt5	622	7	narrower	narrow	JJR
cord-016293-pyb00pt5	622	8	claims	claim	NNS
cord-016293-pyb00pt5	622	9	,	,	,
cord-016293-pyb00pt5	622	10	and	and	CC
cord-016293-pyb00pt5	622	11	the	the	DT
cord-016293-pyb00pt5	622	12	patent	patent	NN
cord-016293-pyb00pt5	622	13	was	be	VBD
cord-016293-pyb00pt5	622	14	granted	grant	VBN
cord-016293-pyb00pt5	622	15	in	in	IN
cord-016293-pyb00pt5	622	16	1992	1992	CD
cord-016293-pyb00pt5	622	17	.	.	.
cord-016293-pyb00pt5	623	1	This	this	DT
cord-016293-pyb00pt5	623	2	has	have	VBZ
cord-016293-pyb00pt5	623	3	since	since	IN
cord-016293-pyb00pt5	623	4	been	be	VBN
cord-016293-pyb00pt5	623	5	repeatedly	repeatedly	RB
cord-016293-pyb00pt5	623	6	challenged	challenge	VBN
cord-016293-pyb00pt5	623	7	,	,	,
cord-016293-pyb00pt5	623	8	primarily	primarily	RB
cord-016293-pyb00pt5	623	9	by	by	IN
cord-016293-pyb00pt5	623	10	groups	group	NNS
cord-016293-pyb00pt5	623	11	objecting	object	VBG
cord-016293-pyb00pt5	623	12	to	to	IN
cord-016293-pyb00pt5	623	13	the	the	DT
cord-016293-pyb00pt5	623	14	judgement	judgement	NN
cord-016293-pyb00pt5	623	15	that	that	WDT
cord-016293-pyb00pt5	623	16	benefits	benefit	VBZ
cord-016293-pyb00pt5	623	17	to	to	IN
cord-016293-pyb00pt5	623	18	humans	human	NNS
cord-016293-pyb00pt5	623	19	outweigh	outweigh	VBP
cord-016293-pyb00pt5	623	20	the	the	DT
cord-016293-pyb00pt5	623	21	suffering	suffering	NN
cord-016293-pyb00pt5	623	22	of	of	IN
cord-016293-pyb00pt5	623	23	the	the	DT
cord-016293-pyb00pt5	623	24	animal	animal	NN
cord-016293-pyb00pt5	623	25	.	.	.
cord-016293-pyb00pt5	624	1	Currently	currently	RB
cord-016293-pyb00pt5	624	2	,	,	,
cord-016293-pyb00pt5	624	3	the	the	DT
cord-016293-pyb00pt5	624	4	patent	patent	NN
cord-016293-pyb00pt5	624	5	applicant	applicant	NN
cord-016293-pyb00pt5	624	6	is	be	VBZ
cord-016293-pyb00pt5	624	7	awaiting	await	VBG
cord-016293-pyb00pt5	624	8	protestors	protestor	NNS
cord-016293-pyb00pt5	624	9	'	'	POS
cord-016293-pyb00pt5	624	10	responses	response	NNS
cord-016293-pyb00pt5	624	11	to	to	IN
cord-016293-pyb00pt5	624	12	a	a	DT
cord-016293-pyb00pt5	624	13	series	series	NN
cord-016293-pyb00pt5	624	14	of	of	IN
cord-016293-pyb00pt5	624	15	possible	possible	JJ
cord-016293-pyb00pt5	624	16	modifications	modification	NNS
cord-016293-pyb00pt5	624	17	to	to	IN
cord-016293-pyb00pt5	624	18	the	the	DT
cord-016293-pyb00pt5	624	19	application	application	NN
cord-016293-pyb00pt5	624	20	.	.	.
cord-016293-pyb00pt5	625	1	Predictions	prediction	NNS
cord-016293-pyb00pt5	625	2	are	be	VBP
cord-016293-pyb00pt5	625	3	that	that	DT
cord-016293-pyb00pt5	625	4	agreement	agreement	NN
cord-016293-pyb00pt5	625	5	will	will	MD
cord-016293-pyb00pt5	625	6	not	not	RB
cord-016293-pyb00pt5	625	7	likely	likely	RB
cord-016293-pyb00pt5	625	8	be	be	VB
cord-016293-pyb00pt5	625	9	forthcoming	forthcoming	JJ
cord-016293-pyb00pt5	625	10	and	and	CC
cord-016293-pyb00pt5	625	11	that	that	IN
cord-016293-pyb00pt5	625	12	the	the	DT
cord-016293-pyb00pt5	625	13	legal	legal	JJ
cord-016293-pyb00pt5	625	14	wrangling	wrangling	NN
cord-016293-pyb00pt5	625	15	will	will	MD
cord-016293-pyb00pt5	625	16	continue	continue	VB
cord-016293-pyb00pt5	625	17	into	into	IN
cord-016293-pyb00pt5	625	18	the	the	DT
cord-016293-pyb00pt5	625	19	future	future	NN
cord-016293-pyb00pt5	625	20	.	.	.
cord-016293-pyb00pt5	626	1	Bringing	bring	VBG
cord-016293-pyb00pt5	626	2	animals	animal	NNS
cord-016293-pyb00pt5	626	3	into	into	IN
cord-016293-pyb00pt5	626	4	the	the	DT
cord-016293-pyb00pt5	626	5	field	field	NN
cord-016293-pyb00pt5	626	6	of	of	IN
cord-016293-pyb00pt5	626	7	controversy	controversy	NN
cord-016293-pyb00pt5	626	8	starting	start	VBG
cord-016293-pyb00pt5	626	9	to	to	TO
cord-016293-pyb00pt5	626	10	swirl	swirl	VB
cord-016293-pyb00pt5	626	11	around	around	RP
cord-016293-pyb00pt5	626	12	GMOs	gmo	NNS
cord-016293-pyb00pt5	626	13	and	and	CC
cord-016293-pyb00pt5	626	14	preceding	precede	VBG
cord-016293-pyb00pt5	626	15	the	the	DT
cord-016293-pyb00pt5	626	16	latter	latter	NN
cord-016293-pyb00pt5	626	17	's	's	POS
cord-016293-pyb00pt5	626	18	commercialization	commercialization	NN
cord-016293-pyb00pt5	626	19	,	,	,
cord-016293-pyb00pt5	626	20	was	be	VBD
cord-016293-pyb00pt5	626	21	the	the	DT
cord-016293-pyb00pt5	626	22	approval	approval	NN
cord-016293-pyb00pt5	626	23	by	by	IN
cord-016293-pyb00pt5	626	24	the	the	DT
cord-016293-pyb00pt5	626	25	FDA	FDA	NNP
cord-016293-pyb00pt5	626	26	of	of	IN
cord-016293-pyb00pt5	626	27	bovine	bovine	JJ
cord-016293-pyb00pt5	626	28	somatotropin	somatotropin	NN
cord-016293-pyb00pt5	626	29	(	(	-LRB-
cord-016293-pyb00pt5	626	30	BST	BST	NNP
cord-016293-pyb00pt5	626	31	)	)	-RRB-
cord-016293-pyb00pt5	626	32	for	for	IN
cord-016293-pyb00pt5	626	33	increased	increase	VBN
cord-016293-pyb00pt5	626	34	milk	milk	NN
cord-016293-pyb00pt5	626	35	production	production	NN
cord-016293-pyb00pt5	626	36	in	in	IN
cord-016293-pyb00pt5	626	37	dairy	dairy	NN
cord-016293-pyb00pt5	626	38	cows	cow	NNS
cord-016293-pyb00pt5	626	39	.	.	.
cord-016293-pyb00pt5	627	1	The	the	DT
cord-016293-pyb00pt5	627	2	FDA	FDA	NNP
cord-016293-pyb00pt5	627	3	's	's	POS
cord-016293-pyb00pt5	627	4	Center	Center	NNP
cord-016293-pyb00pt5	627	5	for	for	IN
cord-016293-pyb00pt5	627	6	Veterinary	Veterinary	NNP
cord-016293-pyb00pt5	627	7	Medicine	Medicine	NNP
cord-016293-pyb00pt5	627	8	(	(	-LRB-
cord-016293-pyb00pt5	627	9	CVM	CVM	NNP
cord-016293-pyb00pt5	627	10	)	)	-RRB-
cord-016293-pyb00pt5	627	11	regulates	regulate	VBZ
cord-016293-pyb00pt5	627	12	the	the	DT
cord-016293-pyb00pt5	627	13	manufacture	manufacture	NN
cord-016293-pyb00pt5	627	14	and	and	CC
cord-016293-pyb00pt5	627	15	distribution	distribution	NN
cord-016293-pyb00pt5	627	16	of	of	IN
cord-016293-pyb00pt5	627	17	food	food	NN
cord-016293-pyb00pt5	627	18	additives	additive	NNS
cord-016293-pyb00pt5	627	19	and	and	CC
cord-016293-pyb00pt5	627	20	drugs	drug	NNS
cord-016293-pyb00pt5	627	21	that	that	WDT
cord-016293-pyb00pt5	627	22	will	will	MD
cord-016293-pyb00pt5	627	23	be	be	VB
cord-016293-pyb00pt5	627	24	given	give	VBN
cord-016293-pyb00pt5	627	25	to	to	IN
cord-016293-pyb00pt5	627	26	animals	animal	NNS
cord-016293-pyb00pt5	627	27	.	.	.
cord-016293-pyb00pt5	628	1	Biotechnology	biotechnology	NN
cord-016293-pyb00pt5	628	2	products	product	NNS
cord-016293-pyb00pt5	628	3	are	be	VBP
cord-016293-pyb00pt5	628	4	a	a	DT
cord-016293-pyb00pt5	628	5	growing	grow	VBG
cord-016293-pyb00pt5	628	6	proportion	proportion	NN
cord-016293-pyb00pt5	628	7	of	of	IN
cord-016293-pyb00pt5	628	8	the	the	DT
cord-016293-pyb00pt5	628	9	animal	animal	NN
cord-016293-pyb00pt5	628	10	health	health	NN
cord-016293-pyb00pt5	628	11	products	product	NNS
cord-016293-pyb00pt5	628	12	and	and	CC
cord-016293-pyb00pt5	628	13	feed	feed	VB
cord-016293-pyb00pt5	628	14	components	component	NNS
cord-016293-pyb00pt5	628	15	regulated	regulate	VBN
cord-016293-pyb00pt5	628	16	by	by	IN
cord-016293-pyb00pt5	628	17	the	the	DT
cord-016293-pyb00pt5	628	18	CVM	CVM	NNP
cord-016293-pyb00pt5	628	19	.	.	.
cord-016293-pyb00pt5	629	1	The	the	DT
cord-016293-pyb00pt5	629	2	Center	Center	NNP
cord-016293-pyb00pt5	629	3	requires	require	VBZ
cord-016293-pyb00pt5	629	4	that	that	IN
cord-016293-pyb00pt5	629	5	food	food	NN
cord-016293-pyb00pt5	629	6	products	product	NNS
cord-016293-pyb00pt5	629	7	from	from	IN
cord-016293-pyb00pt5	629	8	treated	treat	VBN
cord-016293-pyb00pt5	629	9	animals	animal	NNS
cord-016293-pyb00pt5	629	10	must	must	MD
cord-016293-pyb00pt5	629	11	be	be	VB
cord-016293-pyb00pt5	629	12	shown	show	VBN
cord-016293-pyb00pt5	629	13	to	to	TO
cord-016293-pyb00pt5	629	14	be	be	VB
cord-016293-pyb00pt5	629	15	safe	safe	JJ
cord-016293-pyb00pt5	629	16	for	for	IN
cord-016293-pyb00pt5	629	17	human	human	JJ
cord-016293-pyb00pt5	629	18	consumption	consumption	NN
cord-016293-pyb00pt5	629	19	.	.	.
cord-016293-pyb00pt5	630	1	Applicants	applicant	NNS
cord-016293-pyb00pt5	630	2	must	must	MD
cord-016293-pyb00pt5	630	3	show	show	VB
cord-016293-pyb00pt5	630	4	that	that	IN
cord-016293-pyb00pt5	630	5	the	the	DT
cord-016293-pyb00pt5	630	6	drug	drug	NN
cord-016293-pyb00pt5	630	7	is	be	VBZ
cord-016293-pyb00pt5	630	8	effective	effective	JJ
cord-016293-pyb00pt5	630	9	and	and	CC
cord-016293-pyb00pt5	630	10	safe	safe	JJ
cord-016293-pyb00pt5	630	11	for	for	IN
cord-016293-pyb00pt5	630	12	the	the	DT
cord-016293-pyb00pt5	630	13	animal	animal	NN
cord-016293-pyb00pt5	630	14	and	and	CC
cord-016293-pyb00pt5	630	15	that	that	IN
cord-016293-pyb00pt5	630	16	its	-PRON-	PRP$
cord-016293-pyb00pt5	630	17	manufacture	manufacture	NN
cord-016293-pyb00pt5	630	18	will	will	MD
cord-016293-pyb00pt5	630	19	not	not	RB
cord-016293-pyb00pt5	630	20	affect	affect	VB
cord-016293-pyb00pt5	630	21	the	the	DT
cord-016293-pyb00pt5	630	22	environment	environment	NN
cord-016293-pyb00pt5	630	23	.	.	.
cord-016293-pyb00pt5	631	1	They	-PRON-	PRP
cord-016293-pyb00pt5	631	2	must	must	MD
cord-016293-pyb00pt5	631	3	also	also	RB
cord-016293-pyb00pt5	631	4	conduct	conduct	VB
cord-016293-pyb00pt5	631	5	geographically	geographically	RB
cord-016293-pyb00pt5	631	6	dispersed	disperse	VBN
cord-016293-pyb00pt5	631	7	clinical	clinical	JJ
cord-016293-pyb00pt5	631	8	trials	trial	NNS
cord-016293-pyb00pt5	631	9	under	under	IN
cord-016293-pyb00pt5	631	10	an	an	DT
cord-016293-pyb00pt5	631	11	Investigational	Investigational	NNP
cord-016293-pyb00pt5	631	12	New	New	NNP
cord-016293-pyb00pt5	631	13	Animal	Animal	NNP
cord-016293-pyb00pt5	631	14	Drug	Drug	NNP
cord-016293-pyb00pt5	631	15	application	application	NN
cord-016293-pyb00pt5	631	16	with	with	IN
cord-016293-pyb00pt5	631	17	the	the	DT
cord-016293-pyb00pt5	631	18	FDA	FDA	NNP
cord-016293-pyb00pt5	631	19	through	through	IN
cord-016293-pyb00pt5	631	20	which	which	WDT
cord-016293-pyb00pt5	631	21	the	the	DT
cord-016293-pyb00pt5	631	22	agency	agency	NN
cord-016293-pyb00pt5	631	23	controls	control	VBZ
cord-016293-pyb00pt5	631	24	the	the	DT
cord-016293-pyb00pt5	631	25	use	use	NN
cord-016293-pyb00pt5	631	26	of	of	IN
cord-016293-pyb00pt5	631	27	the	the	DT
cord-016293-pyb00pt5	631	28	unapproved	unapproved	JJ
cord-016293-pyb00pt5	631	29	compound	compound	NN
cord-016293-pyb00pt5	631	30	in	in	IN
cord-016293-pyb00pt5	631	31	food	food	NN
cord-016293-pyb00pt5	631	32	animals	animal	NNS
cord-016293-pyb00pt5	631	33	.	.	.
cord-016293-pyb00pt5	632	1	Unlike	unlike	IN
cord-016293-pyb00pt5	632	2	within	within	IN
cord-016293-pyb00pt5	632	3	the	the	DT
cord-016293-pyb00pt5	632	4	EU	EU	NNP
cord-016293-pyb00pt5	632	5	,	,	,
cord-016293-pyb00pt5	632	6	possible	possible	JJ
cord-016293-pyb00pt5	632	7	economic	economic	JJ
cord-016293-pyb00pt5	632	8	and	and	CC
cord-016293-pyb00pt5	632	9	social	social	JJ
cord-016293-pyb00pt5	632	10	issues	issue	NNS
cord-016293-pyb00pt5	632	11	can	can	MD
cord-016293-pyb00pt5	632	12	not	not	RB
cord-016293-pyb00pt5	632	13	be	be	VB
cord-016293-pyb00pt5	632	14	taken	take	VBN
cord-016293-pyb00pt5	632	15	into	into	IN
cord-016293-pyb00pt5	632	16	consideration	consideration	NN
cord-016293-pyb00pt5	632	17	by	by	IN
cord-016293-pyb00pt5	632	18	the	the	DT
cord-016293-pyb00pt5	632	19	FDA	FDA	NNP
cord-016293-pyb00pt5	632	20	in	in	IN
cord-016293-pyb00pt5	632	21	the	the	DT
cord-016293-pyb00pt5	632	22	premarket	premarket	NN
cord-016293-pyb00pt5	632	23	drug	drug	NN
cord-016293-pyb00pt5	632	24	approval	approval	NN
cord-016293-pyb00pt5	632	25	process	process	NN
cord-016293-pyb00pt5	632	26	.	.	.
cord-016293-pyb00pt5	633	1	Under	under	IN
cord-016293-pyb00pt5	633	2	these	these	DT
cord-016293-pyb00pt5	633	3	considerations	consideration	NNS
cord-016293-pyb00pt5	633	4	the	the	DT
cord-016293-pyb00pt5	633	5	safety	safety	NN
cord-016293-pyb00pt5	633	6	and	and	CC
cord-016293-pyb00pt5	633	7	efficacy	efficacy	NN
cord-016293-pyb00pt5	633	8	of	of	IN
cord-016293-pyb00pt5	633	9	rBST	rbst	NN
cord-016293-pyb00pt5	633	10	was	be	VBD
cord-016293-pyb00pt5	633	11	determined	determine	VBN
cord-016293-pyb00pt5	633	12	.	.	.
cord-016293-pyb00pt5	634	1	It	-PRON-	PRP
cord-016293-pyb00pt5	634	2	was	be	VBD
cord-016293-pyb00pt5	634	3	also	also	RB
cord-016293-pyb00pt5	634	4	determined	determine	VBN
cord-016293-pyb00pt5	634	5	that	that	IN
cord-016293-pyb00pt5	634	6	special	special	JJ
cord-016293-pyb00pt5	634	7	labeling	labeling	NN
cord-016293-pyb00pt5	634	8	for	for	IN
cord-016293-pyb00pt5	634	9	milk	milk	NN
cord-016293-pyb00pt5	634	10	derived	derive	VBN
cord-016293-pyb00pt5	634	11	from	from	IN
cord-016293-pyb00pt5	634	12	cows	cow	NNS
cord-016293-pyb00pt5	634	13	that	that	WDT
cord-016293-pyb00pt5	634	14	had	have	VBD
cord-016293-pyb00pt5	634	15	been	be	VBN
cord-016293-pyb00pt5	634	16	treated	treat	VBN
cord-016293-pyb00pt5	634	17	with	with	IN
cord-016293-pyb00pt5	634	18	rBST	rbst	JJ
cord-016293-pyb00pt5	634	19	is	be	VBZ
cord-016293-pyb00pt5	634	20	not	not	RB
cord-016293-pyb00pt5	634	21	required	require	VBN
cord-016293-pyb00pt5	634	22	under	under	IN
cord-016293-pyb00pt5	634	23	FDA	FDA	NNP
cord-016293-pyb00pt5	634	24	food	food	NN
cord-016293-pyb00pt5	634	25	labeling	labeling	NN
cord-016293-pyb00pt5	634	26	laws	law	NNS
cord-016293-pyb00pt5	634	27	because	because	IN
cord-016293-pyb00pt5	634	28	the	the	DT
cord-016293-pyb00pt5	634	29	use	use	NN
cord-016293-pyb00pt5	634	30	of	of	IN
cord-016293-pyb00pt5	634	31	rBST	rbst	NN
cord-016293-pyb00pt5	634	32	does	do	VBZ
cord-016293-pyb00pt5	634	33	not	not	RB
cord-016293-pyb00pt5	634	34	effect	effect	VB
cord-016293-pyb00pt5	634	35	the	the	DT
cord-016293-pyb00pt5	634	36	quality	quality	NN
cord-016293-pyb00pt5	634	37	or	or	CC
cord-016293-pyb00pt5	634	38	the	the	DT
cord-016293-pyb00pt5	634	39	composition	composition	NN
cord-016293-pyb00pt5	634	40	of	of	IN
cord-016293-pyb00pt5	634	41	the	the	DT
cord-016293-pyb00pt5	634	42	milk	milk	NN
cord-016293-pyb00pt5	634	43	.	.	.
cord-016293-pyb00pt5	635	1	Work	work	VB
cord-016293-pyb00pt5	635	2	with	with	IN
cord-016293-pyb00pt5	635	3	fish	fish	NN
cord-016293-pyb00pt5	635	4	proceeded	proceed	VBD
cord-016293-pyb00pt5	635	5	a	a	DT
cord-016293-pyb00pt5	635	6	pace	pace	NN
cord-016293-pyb00pt5	635	7	throughout	throughout	IN
cord-016293-pyb00pt5	635	8	the	the	DT
cord-016293-pyb00pt5	635	9	decade	decade	NN
cord-016293-pyb00pt5	635	10	.	.	.
cord-016293-pyb00pt5	636	1	Gene	gene	NN
cord-016293-pyb00pt5	636	2	transfer	transfer	NN
cord-016293-pyb00pt5	636	3	techniques	technique	NNS
cord-016293-pyb00pt5	636	4	have	have	VBP
cord-016293-pyb00pt5	636	5	been	be	VBN
cord-016293-pyb00pt5	636	6	applied	apply	VBN
cord-016293-pyb00pt5	636	7	to	to	IN
cord-016293-pyb00pt5	636	8	a	a	DT
cord-016293-pyb00pt5	636	9	large	large	JJ
cord-016293-pyb00pt5	636	10	number	number	NN
cord-016293-pyb00pt5	636	11	of	of	IN
cord-016293-pyb00pt5	636	12	aquatic	aquatic	JJ
cord-016293-pyb00pt5	636	13	organisms	organism	NNS
cord-016293-pyb00pt5	636	14	,	,	,
cord-016293-pyb00pt5	636	15	both	both	DT
cord-016293-pyb00pt5	636	16	vertebrates	vertebrate	NNS
cord-016293-pyb00pt5	636	17	and	and	CC
cord-016293-pyb00pt5	636	18	invertebrates	invertebrate	NNS
cord-016293-pyb00pt5	636	19	.	.	.
cord-016293-pyb00pt5	637	1	Gene	gene	NN
cord-016293-pyb00pt5	637	2	transfer	transfer	NN
cord-016293-pyb00pt5	637	3	experiments	experiment	NNS
cord-016293-pyb00pt5	637	4	have	have	VBP
cord-016293-pyb00pt5	637	5	targeted	target	VBN
cord-016293-pyb00pt5	637	6	a	a	DT
cord-016293-pyb00pt5	637	7	wide	wide	JJ
cord-016293-pyb00pt5	637	8	variety	variety	NN
cord-016293-pyb00pt5	637	9	of	of	IN
cord-016293-pyb00pt5	637	10	applications	application	NNS
cord-016293-pyb00pt5	637	11	,	,	,
cord-016293-pyb00pt5	637	12	including	include	VBG
cord-016293-pyb00pt5	637	13	the	the	DT
cord-016293-pyb00pt5	637	14	study	study	NN
cord-016293-pyb00pt5	637	15	of	of	IN
cord-016293-pyb00pt5	637	16	gene	gene	NN
cord-016293-pyb00pt5	637	17	structure	structure	NN
cord-016293-pyb00pt5	637	18	and	and	CC
cord-016293-pyb00pt5	637	19	function	function	NN
cord-016293-pyb00pt5	637	20	,	,	,
cord-016293-pyb00pt5	637	21	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	637	22	production	production	NN
cord-016293-pyb00pt5	637	23	,	,	,
cord-016293-pyb00pt5	637	24	and	and	CC
cord-016293-pyb00pt5	637	25	use	use	VB
cord-016293-pyb00pt5	637	26	in	in	IN
cord-016293-pyb00pt5	637	27	fisheries	fishery	NNS
cord-016293-pyb00pt5	637	28	management	management	NN
cord-016293-pyb00pt5	637	29	programs	program	NNS
cord-016293-pyb00pt5	637	30	.	.	.
cord-016293-pyb00pt5	638	1	Because	because	IN
cord-016293-pyb00pt5	638	2	fish	fish	NN
cord-016293-pyb00pt5	638	3	have	have	VBP
cord-016293-pyb00pt5	638	4	high	high	JJ
cord-016293-pyb00pt5	638	5	fecundity	fecundity	NN
cord-016293-pyb00pt5	638	6	,	,	,
cord-016293-pyb00pt5	638	7	large	large	JJ
cord-016293-pyb00pt5	638	8	eggs	egg	NNS
cord-016293-pyb00pt5	638	9	,	,	,
cord-016293-pyb00pt5	638	10	and	and	CC
cord-016293-pyb00pt5	638	11	do	do	VBP
cord-016293-pyb00pt5	638	12	not	not	RB
cord-016293-pyb00pt5	638	13	require	require	VB
cord-016293-pyb00pt5	638	14	reimplantation	reimplantation	NN
cord-016293-pyb00pt5	638	15	of	of	IN
cord-016293-pyb00pt5	638	16	embryos	embryo	NNS
cord-016293-pyb00pt5	638	17	,	,	,
cord-016293-pyb00pt5	638	18	transgenic	transgenic	JJ
cord-016293-pyb00pt5	638	19	fish	fish	NN
cord-016293-pyb00pt5	638	20	prove	prove	VBP
cord-016293-pyb00pt5	638	21	attractive	attractive	JJ
cord-016293-pyb00pt5	638	22	model	model	NN
cord-016293-pyb00pt5	638	23	systems	system	NNS
cord-016293-pyb00pt5	638	24	in	in	IN
cord-016293-pyb00pt5	638	25	which	which	WDT
cord-016293-pyb00pt5	638	26	to	to	TO
cord-016293-pyb00pt5	638	27	study	study	VB
cord-016293-pyb00pt5	638	28	gene	gene	NN
cord-016293-pyb00pt5	638	29	expression	expression	NN
cord-016293-pyb00pt5	638	30	.	.	.
cord-016293-pyb00pt5	639	1	Transgenic	transgenic	JJ
cord-016293-pyb00pt5	639	2	zebrafish	zebrafish	NN
cord-016293-pyb00pt5	639	3	have	have	VBP
cord-016293-pyb00pt5	639	4	found	find	VBN
cord-016293-pyb00pt5	639	5	utility	utility	NN
cord-016293-pyb00pt5	639	6	in	in	IN
cord-016293-pyb00pt5	639	7	studies	study	NNS
cord-016293-pyb00pt5	639	8	of	of	IN
cord-016293-pyb00pt5	639	9	embryogenesis	embryogenesis	NN
cord-016293-pyb00pt5	639	10	,	,	,
cord-016293-pyb00pt5	639	11	with	with	IN
cord-016293-pyb00pt5	639	12	expression	expression	NN
cord-016293-pyb00pt5	639	13	of	of	IN
cord-016293-pyb00pt5	639	14	transgenes	transgene	NNS
cord-016293-pyb00pt5	639	15	marking	mark	VBG
cord-016293-pyb00pt5	639	16	cell	cell	NN
cord-016293-pyb00pt5	639	17	lineages	lineage	NNS
cord-016293-pyb00pt5	639	18	or	or	CC
cord-016293-pyb00pt5	639	19	providing	provide	VBG
cord-016293-pyb00pt5	639	20	the	the	DT
cord-016293-pyb00pt5	639	21	basis	basis	NN
cord-016293-pyb00pt5	639	22	for	for	IN
cord-016293-pyb00pt5	639	23	study	study	NN
cord-016293-pyb00pt5	639	24	of	of	IN
cord-016293-pyb00pt5	639	25	promoter	promoter	NN
cord-016293-pyb00pt5	639	26	or	or	CC
cord-016293-pyb00pt5	639	27	structural	structural	JJ
cord-016293-pyb00pt5	639	28	gene	gene	NN
cord-016293-pyb00pt5	639	29	function	function	NN
cord-016293-pyb00pt5	639	30	.	.	.
cord-016293-pyb00pt5	640	1	Although	although	IN
cord-016293-pyb00pt5	640	2	not	not	RB
cord-016293-pyb00pt5	640	3	as	as	RB
cord-016293-pyb00pt5	640	4	widely	widely	RB
cord-016293-pyb00pt5	640	5	used	use	VBN
cord-016293-pyb00pt5	640	6	as	as	IN
cord-016293-pyb00pt5	640	7	zebrafish	zebrafish	NN
cord-016293-pyb00pt5	640	8	,	,	,
cord-016293-pyb00pt5	640	9	transgenic	transgenic	JJ
cord-016293-pyb00pt5	640	10	medaka	medaka	NN
cord-016293-pyb00pt5	640	11	and	and	CC
cord-016293-pyb00pt5	640	12	goldfish	goldfish	NN
cord-016293-pyb00pt5	640	13	have	have	VBP
cord-016293-pyb00pt5	640	14	been	be	VBN
cord-016293-pyb00pt5	640	15	used	use	VBN
cord-016293-pyb00pt5	640	16	for	for	IN
cord-016293-pyb00pt5	640	17	studies	study	NNS
cord-016293-pyb00pt5	640	18	of	of	IN
cord-016293-pyb00pt5	640	19	promoter	promoter	NN
cord-016293-pyb00pt5	640	20	function	function	NN
cord-016293-pyb00pt5	640	21	.	.	.
cord-016293-pyb00pt5	641	1	This	this	DT
cord-016293-pyb00pt5	641	2	body	body	NN
cord-016293-pyb00pt5	641	3	of	of	IN
cord-016293-pyb00pt5	641	4	research	research	NN
cord-016293-pyb00pt5	641	5	indicates	indicate	VBZ
cord-016293-pyb00pt5	641	6	that	that	IN
cord-016293-pyb00pt5	641	7	transgenic	transgenic	JJ
cord-016293-pyb00pt5	641	8	fish	fish	NN
cord-016293-pyb00pt5	641	9	provide	provide	VBP
cord-016293-pyb00pt5	641	10	useful	useful	JJ
cord-016293-pyb00pt5	641	11	models	model	NNS
cord-016293-pyb00pt5	641	12	of	of	IN
cord-016293-pyb00pt5	641	13	gene	gene	NN
cord-016293-pyb00pt5	641	14	expression	expression	NN
cord-016293-pyb00pt5	641	15	,	,	,
cord-016293-pyb00pt5	641	16	reliably	reliably	RB
cord-016293-pyb00pt5	641	17	modeling	model	VBG
cord-016293-pyb00pt5	641	18	that	that	DT
cord-016293-pyb00pt5	641	19	in	in	IN
cord-016293-pyb00pt5	641	20	"	"	``
cord-016293-pyb00pt5	641	21	higher	high	JJR
cord-016293-pyb00pt5	641	22	"	"	''
cord-016293-pyb00pt5	641	23	vertebrates	vertebrate	NNS
cord-016293-pyb00pt5	641	24	.	.	.
cord-016293-pyb00pt5	642	1	Perhaps	perhaps	RB
cord-016293-pyb00pt5	642	2	the	the	DT
cord-016293-pyb00pt5	642	3	largest	large	JJS
cord-016293-pyb00pt5	642	4	number	number	NN
cord-016293-pyb00pt5	642	5	of	of	IN
cord-016293-pyb00pt5	642	6	gene	gene	NN
cord-016293-pyb00pt5	642	7	transfer	transfer	NN
cord-016293-pyb00pt5	642	8	experiments	experiment	NNS
cord-016293-pyb00pt5	642	9	address	address	VBP
cord-016293-pyb00pt5	642	10	the	the	DT
cord-016293-pyb00pt5	642	11	goal	goal	NN
cord-016293-pyb00pt5	642	12	of	of	IN
cord-016293-pyb00pt5	642	13	genetic	genetic	JJ
cord-016293-pyb00pt5	642	14	improvement	improvement	NN
cord-016293-pyb00pt5	642	15	for	for	IN
cord-016293-pyb00pt5	642	16	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	642	17	production	production	NN
cord-016293-pyb00pt5	642	18	purposes	purpose	NNS
cord-016293-pyb00pt5	642	19	.	.	.
cord-016293-pyb00pt5	643	1	The	the	DT
cord-016293-pyb00pt5	643	2	principal	principal	JJ
cord-016293-pyb00pt5	643	3	area	area	NN
cord-016293-pyb00pt5	643	4	of	of	IN
cord-016293-pyb00pt5	643	5	research	research	NN
cord-016293-pyb00pt5	643	6	has	have	VBZ
cord-016293-pyb00pt5	643	7	focused	focus	VBN
cord-016293-pyb00pt5	643	8	on	on	IN
cord-016293-pyb00pt5	643	9	growth	growth	NN
cord-016293-pyb00pt5	643	10	performance	performance	NN
cord-016293-pyb00pt5	643	11	,	,	,
cord-016293-pyb00pt5	643	12	and	and	CC
cord-016293-pyb00pt5	643	13	initial	initial	JJ
cord-016293-pyb00pt5	643	14	transgenic	transgenic	JJ
cord-016293-pyb00pt5	643	15	growth	growth	NN
cord-016293-pyb00pt5	643	16	hormone	hormone	NN
cord-016293-pyb00pt5	643	17	(	(	-LRB-
cord-016293-pyb00pt5	643	18	GH	gh	NN
cord-016293-pyb00pt5	643	19	)	)	-RRB-
cord-016293-pyb00pt5	643	20	fish	fish	NN
cord-016293-pyb00pt5	643	21	models	model	NNS
cord-016293-pyb00pt5	643	22	have	have	VBP
cord-016293-pyb00pt5	643	23	demonstrated	demonstrate	VBN
cord-016293-pyb00pt5	643	24	accelerated	accelerate	VBN
cord-016293-pyb00pt5	643	25	and	and	CC
cord-016293-pyb00pt5	643	26	beneficial	beneficial	JJ
cord-016293-pyb00pt5	643	27	phenotypes	phenotype	NNS
cord-016293-pyb00pt5	643	28	.	.	.
cord-016293-pyb00pt5	644	1	DNA	dna	NN
cord-016293-pyb00pt5	644	2	microinjection	microinjection	NN
cord-016293-pyb00pt5	644	3	methods	method	NNS
cord-016293-pyb00pt5	644	4	have	have	VBP
cord-016293-pyb00pt5	644	5	propelled	propel	VBN
cord-016293-pyb00pt5	644	6	the	the	DT
cord-016293-pyb00pt5	644	7	many	many	JJ
cord-016293-pyb00pt5	644	8	studies	study	NNS
cord-016293-pyb00pt5	644	9	reported	report	VBD
cord-016293-pyb00pt5	644	10	and	and	CC
cord-016293-pyb00pt5	644	11	have	have	VBP
cord-016293-pyb00pt5	644	12	been	be	VBN
cord-016293-pyb00pt5	644	13	most	most	RBS
cord-016293-pyb00pt5	644	14	effective	effective	JJ
cord-016293-pyb00pt5	644	15	due	due	IN
cord-016293-pyb00pt5	644	16	to	to	IN
cord-016293-pyb00pt5	644	17	the	the	DT
cord-016293-pyb00pt5	644	18	relative	relative	JJ
cord-016293-pyb00pt5	644	19	ease	ease	NN
cord-016293-pyb00pt5	644	20	of	of	IN
cord-016293-pyb00pt5	644	21	working	work	VBG
cord-016293-pyb00pt5	644	22	with	with	IN
cord-016293-pyb00pt5	644	23	fish	fish	NN
cord-016293-pyb00pt5	644	24	embryos	embryo	NNS
cord-016293-pyb00pt5	644	25	.	.	.
cord-016293-pyb00pt5	645	1	Bob	Bob	NNP
cord-016293-pyb00pt5	645	2	Devlins	Devlins	NNP
cord-016293-pyb00pt5	645	3	'	'	POS
cord-016293-pyb00pt5	645	4	group	group	NN
cord-016293-pyb00pt5	645	5	in	in	IN
cord-016293-pyb00pt5	645	6	Vancouver	Vancouver	NNP
cord-016293-pyb00pt5	645	7	has	have	VBZ
cord-016293-pyb00pt5	645	8	demonstrated	demonstrate	VBN
cord-016293-pyb00pt5	645	9	extraordinary	extraordinary	JJ
cord-016293-pyb00pt5	645	10	growth	growth	NN
cord-016293-pyb00pt5	645	11	rate	rate	NN
cord-016293-pyb00pt5	645	12	in	in	IN
cord-016293-pyb00pt5	645	13	coho	coho	NNS
cord-016293-pyb00pt5	645	14	salmon	salmon	NN
cord-016293-pyb00pt5	645	15	which	which	WDT
cord-016293-pyb00pt5	645	16	were	be	VBD
cord-016293-pyb00pt5	645	17	transformed	transform	VBN
cord-016293-pyb00pt5	645	18	with	with	IN
cord-016293-pyb00pt5	645	19	a	a	DT
cord-016293-pyb00pt5	645	20	growth	growth	NN
cord-016293-pyb00pt5	645	21	hormone	hormone	NN
cord-016293-pyb00pt5	645	22	from	from	IN
cord-016293-pyb00pt5	645	23	sockeye	sockeye	NN
cord-016293-pyb00pt5	645	24	salmon	salmon	NN
cord-016293-pyb00pt5	645	25	.	.	.
cord-016293-pyb00pt5	646	1	The	the	DT
cord-016293-pyb00pt5	646	2	transgenics	transgenic	NNS
cord-016293-pyb00pt5	646	3	achieve	achieve	VBP
cord-016293-pyb00pt5	646	4	up	up	IN
cord-016293-pyb00pt5	646	5	to	to	IN
cord-016293-pyb00pt5	646	6	eleven	eleven	CD
cord-016293-pyb00pt5	646	7	times	time	NNS
cord-016293-pyb00pt5	646	8	the	the	DT
cord-016293-pyb00pt5	646	9	size	size	NN
cord-016293-pyb00pt5	646	10	of	of	IN
cord-016293-pyb00pt5	646	11	their	-PRON-	PRP$
cord-016293-pyb00pt5	646	12	littermates	littermate	NNS
cord-016293-pyb00pt5	646	13	within	within	IN
cord-016293-pyb00pt5	646	14	six	six	CD
cord-016293-pyb00pt5	646	15	months	month	NNS
cord-016293-pyb00pt5	646	16	,	,	,
cord-016293-pyb00pt5	646	17	reaching	reach	VBG
cord-016293-pyb00pt5	646	18	maturity	maturity	NN
cord-016293-pyb00pt5	646	19	in	in	IN
cord-016293-pyb00pt5	646	20	about	about	IN
cord-016293-pyb00pt5	646	21	half	half	PDT
cord-016293-pyb00pt5	646	22	the	the	DT
cord-016293-pyb00pt5	646	23	time	time	NN
cord-016293-pyb00pt5	646	24	.	.	.
cord-016293-pyb00pt5	647	1	Interestingly	interestingly	RB
cord-016293-pyb00pt5	647	2	this	this	DT
cord-016293-pyb00pt5	647	3	dramatic	dramatic	JJ
cord-016293-pyb00pt5	647	4	effect	effect	NN
cord-016293-pyb00pt5	647	5	is	be	VBZ
cord-016293-pyb00pt5	647	6	only	only	RB
cord-016293-pyb00pt5	647	7	observed	observe	VBN
cord-016293-pyb00pt5	647	8	in	in	IN
cord-016293-pyb00pt5	647	9	feeding	feed	VBG
cord-016293-pyb00pt5	647	10	pins	pin	NNS
cord-016293-pyb00pt5	647	11	where	where	WRB
cord-016293-pyb00pt5	647	12	the	the	DT
cord-016293-pyb00pt5	647	13	transgenics	transgenic	NNS
cord-016293-pyb00pt5	647	14	'	'	POS
cord-016293-pyb00pt5	647	15	ferocious	ferocious	JJ
cord-016293-pyb00pt5	647	16	appetites	appetite	NNS
cord-016293-pyb00pt5	647	17	demands	demand	VBZ
cord-016293-pyb00pt5	647	18	constant	constant	JJ
cord-016293-pyb00pt5	647	19	feeding	feeding	NN
cord-016293-pyb00pt5	647	20	.	.	.
cord-016293-pyb00pt5	648	1	If	if	IN
cord-016293-pyb00pt5	648	2	the	the	DT
cord-016293-pyb00pt5	648	3	fish	fish	NN
cord-016293-pyb00pt5	648	4	are	be	VBP
cord-016293-pyb00pt5	648	5	left	leave	VBN
cord-016293-pyb00pt5	648	6	to	to	IN
cord-016293-pyb00pt5	648	7	their	-PRON-	PRP$
cord-016293-pyb00pt5	648	8	own	own	JJ
cord-016293-pyb00pt5	648	9	devices	device	NNS
cord-016293-pyb00pt5	648	10	and	and	CC
cord-016293-pyb00pt5	648	11	must	must	MD
cord-016293-pyb00pt5	648	12	forage	forage	VB
cord-016293-pyb00pt5	648	13	for	for	IN
cord-016293-pyb00pt5	648	14	themselves	-PRON-	PRP
cord-016293-pyb00pt5	648	15	,	,	,
cord-016293-pyb00pt5	648	16	they	-PRON-	PRP
cord-016293-pyb00pt5	648	17	appear	appear	VBP
cord-016293-pyb00pt5	648	18	to	to	TO
cord-016293-pyb00pt5	648	19	be	be	VB
cord-016293-pyb00pt5	648	20	out	out	RB
cord-016293-pyb00pt5	648	21	-	-	HYPH
cord-016293-pyb00pt5	648	22	competed	compete	VBN
cord-016293-pyb00pt5	648	23	by	by	IN
cord-016293-pyb00pt5	648	24	their	-PRON-	PRP$
cord-016293-pyb00pt5	648	25	smarter	smart	JJR
cord-016293-pyb00pt5	648	26	siblings	sibling	NNS
cord-016293-pyb00pt5	648	27	.	.	.
cord-016293-pyb00pt5	649	1	However	however	RB
cord-016293-pyb00pt5	649	2	most	most	JJS
cord-016293-pyb00pt5	649	3	studies	study	NNS
cord-016293-pyb00pt5	649	4	,	,	,
cord-016293-pyb00pt5	649	5	such	such	JJ
cord-016293-pyb00pt5	649	6	as	as	IN
cord-016293-pyb00pt5	649	7	those	those	DT
cord-016293-pyb00pt5	649	8	involving	involve	VBG
cord-016293-pyb00pt5	649	9	transgenic	transgenic	JJ
cord-016293-pyb00pt5	649	10	Atlantic	Atlantic	NNP
cord-016293-pyb00pt5	649	11	salmon	salmon	NN
cord-016293-pyb00pt5	649	12	and	and	CC
cord-016293-pyb00pt5	649	13	channel	channel	NN
cord-016293-pyb00pt5	649	14	catfish	catfish	NNS
cord-016293-pyb00pt5	649	15	,	,	,
cord-016293-pyb00pt5	649	16	report	report	VBP
cord-016293-pyb00pt5	649	17	growth	growth	NN
cord-016293-pyb00pt5	649	18	rate	rate	NN
cord-016293-pyb00pt5	649	19	enhancement	enhancement	NN
cord-016293-pyb00pt5	649	20	on	on	IN
cord-016293-pyb00pt5	649	21	the	the	DT
cord-016293-pyb00pt5	649	22	order	order	NN
cord-016293-pyb00pt5	649	23	of	of	IN
cord-016293-pyb00pt5	649	24	30	30	CD
cord-016293-pyb00pt5	649	25	-	-	SYM
cord-016293-pyb00pt5	649	26	60	60	CD
cord-016293-pyb00pt5	649	27	%	%	NN
cord-016293-pyb00pt5	649	28	.	.	.
cord-016293-pyb00pt5	650	1	In	in	IN
cord-016293-pyb00pt5	650	2	addition	addition	NN
cord-016293-pyb00pt5	650	3	to	to	IN
cord-016293-pyb00pt5	650	4	the	the	DT
cord-016293-pyb00pt5	650	5	species	specie	NNS
cord-016293-pyb00pt5	650	6	mentioned	mention	VBN
cord-016293-pyb00pt5	650	7	,	,	,
cord-016293-pyb00pt5	650	8	GH	GH	NNP
cord-016293-pyb00pt5	650	9	genes	gene	NNS
cord-016293-pyb00pt5	650	10	also	also	RB
cord-016293-pyb00pt5	650	11	have	have	VBP
cord-016293-pyb00pt5	650	12	been	be	VBN
cord-016293-pyb00pt5	650	13	transferred	transfer	VBN
cord-016293-pyb00pt5	650	14	into	into	IN
cord-016293-pyb00pt5	650	15	striped	striped	JJ
cord-016293-pyb00pt5	650	16	bass	bass	NN
cord-016293-pyb00pt5	650	17	,	,	,
cord-016293-pyb00pt5	650	18	tilapia	tilapia	NN
cord-016293-pyb00pt5	650	19	,	,	,
cord-016293-pyb00pt5	650	20	rainbow	rainbow	NN
cord-016293-pyb00pt5	650	21	trout	trout	NNS
cord-016293-pyb00pt5	650	22	,	,	,
cord-016293-pyb00pt5	650	23	gilthead	gilthead	NNP
cord-016293-pyb00pt5	650	24	sea	sea	NN
cord-016293-pyb00pt5	650	25	bream	bream	NN
cord-016293-pyb00pt5	650	26	,	,	,
cord-016293-pyb00pt5	650	27	common	common	JJ
cord-016293-pyb00pt5	650	28	carp	carp	NN
cord-016293-pyb00pt5	650	29	,	,	,
cord-016293-pyb00pt5	650	30	bluntnose	bluntnose	NNP
cord-016293-pyb00pt5	650	31	bream	bream	NN
cord-016293-pyb00pt5	650	32	,	,	,
cord-016293-pyb00pt5	650	33	loach	loach	NN
cord-016293-pyb00pt5	650	34	,	,	,
cord-016293-pyb00pt5	650	35	and	and	CC
cord-016293-pyb00pt5	650	36	other	other	JJ
cord-016293-pyb00pt5	650	37	fishes	fish	NNS
cord-016293-pyb00pt5	650	38	.	.	.
cord-016293-pyb00pt5	651	1	Shellfish	shellfish	NN
cord-016293-pyb00pt5	651	2	also	also	RB
cord-016293-pyb00pt5	651	3	are	be	VBP
cord-016293-pyb00pt5	651	4	subject	subject	JJ
cord-016293-pyb00pt5	651	5	to	to	IN
cord-016293-pyb00pt5	651	6	gene	gene	NN
cord-016293-pyb00pt5	651	7	transfer	transfer	NN
cord-016293-pyb00pt5	651	8	toward	toward	IN
cord-016293-pyb00pt5	651	9	the	the	DT
cord-016293-pyb00pt5	651	10	goal	goal	NN
cord-016293-pyb00pt5	651	11	of	of	IN
cord-016293-pyb00pt5	651	12	intensifying	intensify	VBG
cord-016293-pyb00pt5	651	13	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	651	14	production	production	NN
cord-016293-pyb00pt5	651	15	.	.	.
cord-016293-pyb00pt5	652	1	Growth	growth	NN
cord-016293-pyb00pt5	652	2	of	of	IN
cord-016293-pyb00pt5	652	3	abalone	abalone	NN
cord-016293-pyb00pt5	652	4	expressing	express	VBG
cord-016293-pyb00pt5	652	5	an	an	DT
cord-016293-pyb00pt5	652	6	introduced	introduce	VBN
cord-016293-pyb00pt5	652	7	GH	GH	NNP
cord-016293-pyb00pt5	652	8	gene	gene	NN
cord-016293-pyb00pt5	652	9	is	be	VBZ
cord-016293-pyb00pt5	652	10	being	be	VBG
cord-016293-pyb00pt5	652	11	evaluated	evaluate	VBN
cord-016293-pyb00pt5	652	12	;	;	:
cord-016293-pyb00pt5	652	13	accelerated	accelerated	JJ
cord-016293-pyb00pt5	652	14	growth	growth	NN
cord-016293-pyb00pt5	652	15	would	would	MD
cord-016293-pyb00pt5	652	16	prove	prove	VB
cord-016293-pyb00pt5	652	17	a	a	DT
cord-016293-pyb00pt5	652	18	boon	boon	NN
cord-016293-pyb00pt5	652	19	for	for	IN
cord-016293-pyb00pt5	652	20	culture	culture	NN
cord-016293-pyb00pt5	652	21	of	of	IN
cord-016293-pyb00pt5	652	22	the	the	DT
cord-016293-pyb00pt5	652	23	slowgrowing	slowgrowe	VBG
cord-016293-pyb00pt5	652	24	mollusk	mollusk	NN
cord-016293-pyb00pt5	652	25	.	.	.
cord-016293-pyb00pt5	653	1	A	a	DT
cord-016293-pyb00pt5	653	2	marker	marker	NN
cord-016293-pyb00pt5	653	3	gene	gene	NN
cord-016293-pyb00pt5	653	4	was	be	VBD
cord-016293-pyb00pt5	653	5	introduced	introduce	VBN
cord-016293-pyb00pt5	653	6	successfully	successfully	RB
cord-016293-pyb00pt5	653	7	into	into	IN
cord-016293-pyb00pt5	653	8	giant	giant	JJ
cord-016293-pyb00pt5	653	9	prawn	prawn	NN
cord-016293-pyb00pt5	653	10	,	,	,
cord-016293-pyb00pt5	653	11	demonstrating	demonstrate	VBG
cord-016293-pyb00pt5	653	12	feasibility	feasibility	NN
cord-016293-pyb00pt5	653	13	of	of	IN
cord-016293-pyb00pt5	653	14	gene	gene	NN
cord-016293-pyb00pt5	653	15	transfer	transfer	NN
cord-016293-pyb00pt5	653	16	in	in	IN
cord-016293-pyb00pt5	653	17	crustaceans	crustacean	NNS
cord-016293-pyb00pt5	653	18	,	,	,
cord-016293-pyb00pt5	653	19	and	and	CC
cord-016293-pyb00pt5	653	20	opening	open	VBG
cord-016293-pyb00pt5	653	21	the	the	DT
cord-016293-pyb00pt5	653	22	possibility	possibility	NN
cord-016293-pyb00pt5	653	23	of	of	IN
cord-016293-pyb00pt5	653	24	work	work	NN
cord-016293-pyb00pt5	653	25	involving	involve	VBG
cord-016293-pyb00pt5	653	26	genes	gene	NNS
cord-016293-pyb00pt5	653	27	affecting	affect	VBG
cord-016293-pyb00pt5	653	28	economically	economically	RB
cord-016293-pyb00pt5	653	29	important	important	JJ
cord-016293-pyb00pt5	653	30	traits	trait	NNS
cord-016293-pyb00pt5	653	31	.	.	.
cord-016293-pyb00pt5	654	1	In	in	IN
cord-016293-pyb00pt5	654	2	the	the	DT
cord-016293-pyb00pt5	654	3	ornamental	ornamental	JJ
cord-016293-pyb00pt5	654	4	fish	fish	NN
cord-016293-pyb00pt5	654	5	sector	sector	NN
cord-016293-pyb00pt5	654	6	of	of	IN
cord-016293-pyb00pt5	654	7	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	654	8	,	,	,
cord-016293-pyb00pt5	654	9	ongoing	ongoing	JJ
cord-016293-pyb00pt5	654	10	work	work	NN
cord-016293-pyb00pt5	654	11	addresses	address	VBZ
cord-016293-pyb00pt5	654	12	the	the	DT
cord-016293-pyb00pt5	654	13	development	development	NN
cord-016293-pyb00pt5	654	14	of	of	IN
cord-016293-pyb00pt5	654	15	fish	fish	NN
cord-016293-pyb00pt5	654	16	with	with	IN
cord-016293-pyb00pt5	654	17	unique	unique	JJ
cord-016293-pyb00pt5	654	18	coloring	coloring	NN
cord-016293-pyb00pt5	654	19	or	or	CC
cord-016293-pyb00pt5	654	20	patterning	patterning	NN
cord-016293-pyb00pt5	654	21	.	.	.
cord-016293-pyb00pt5	655	1	A	a	DT
cord-016293-pyb00pt5	655	2	number	number	NN
cord-016293-pyb00pt5	655	3	of	of	IN
cord-016293-pyb00pt5	655	4	companies	company	NNS
cord-016293-pyb00pt5	655	5	have	have	VBP
cord-016293-pyb00pt5	655	6	been	be	VBN
cord-016293-pyb00pt5	655	7	founded	found	VBN
cord-016293-pyb00pt5	655	8	to	to	TO
cord-016293-pyb00pt5	655	9	pursue	pursue	VB
cord-016293-pyb00pt5	655	10	commercialization	commercialization	NN
cord-016293-pyb00pt5	655	11	of	of	IN
cord-016293-pyb00pt5	655	12	transgenics	transgenic	NNS
cord-016293-pyb00pt5	655	13	for	for	IN
cord-016293-pyb00pt5	655	14	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	655	15	.	.	.
cord-016293-pyb00pt5	656	1	As	as	IN
cord-016293-pyb00pt5	656	2	most	most	JJS
cord-016293-pyb00pt5	656	3	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	656	4	species	specie	NNS
cord-016293-pyb00pt5	656	5	mature	mature	VBP
cord-016293-pyb00pt5	656	6	at	at	IN
cord-016293-pyb00pt5	656	7	2	2	CD
cord-016293-pyb00pt5	656	8	-	-	SYM
cord-016293-pyb00pt5	656	9	3	3	CD
cord-016293-pyb00pt5	656	10	years	year	NNS
cord-016293-pyb00pt5	656	11	of	of	IN
cord-016293-pyb00pt5	656	12	age	age	NN
cord-016293-pyb00pt5	656	13	,	,	,
cord-016293-pyb00pt5	656	14	most	most	JJS
cord-016293-pyb00pt5	656	15	transgenic	transgenic	JJ
cord-016293-pyb00pt5	656	16	lines	line	NNS
cord-016293-pyb00pt5	656	17	are	be	VBP
cord-016293-pyb00pt5	656	18	still	still	RB
cord-016293-pyb00pt5	656	19	in	in	IN
cord-016293-pyb00pt5	656	20	development	development	NN
cord-016293-pyb00pt5	656	21	and	and	CC
cord-016293-pyb00pt5	656	22	have	have	VBP
cord-016293-pyb00pt5	656	23	yet	yet	RB
cord-016293-pyb00pt5	656	24	to	to	TO
cord-016293-pyb00pt5	656	25	be	be	VB
cord-016293-pyb00pt5	656	26	tested	test	VBN
cord-016293-pyb00pt5	656	27	for	for	IN
cord-016293-pyb00pt5	656	28	performance	performance	NN
cord-016293-pyb00pt5	656	29	under	under	IN
cord-016293-pyb00pt5	656	30	culture	culture	NN
cord-016293-pyb00pt5	656	31	conditions	condition	NNS
cord-016293-pyb00pt5	656	32	.	.	.
cord-016293-pyb00pt5	657	1	Extending	extend	VBG
cord-016293-pyb00pt5	657	2	earlier	early	JJR
cord-016293-pyb00pt5	657	3	research	research	NN
cord-016293-pyb00pt5	657	4	that	that	WDT
cord-016293-pyb00pt5	657	5	identified	identify	VBD
cord-016293-pyb00pt5	657	6	methylfarnesoate	methylfarnesoate	JJ
cord-016293-pyb00pt5	657	7	(	(	-LRB-
cord-016293-pyb00pt5	657	8	MF	MF	NNP
cord-016293-pyb00pt5	657	9	)	)	-RRB-
cord-016293-pyb00pt5	657	10	as	as	IN
cord-016293-pyb00pt5	657	11	a	a	DT
cord-016293-pyb00pt5	657	12	juvenile	juvenile	JJ
cord-016293-pyb00pt5	657	13	hormone	hormone	NN
cord-016293-pyb00pt5	657	14	in	in	IN
cord-016293-pyb00pt5	657	15	crustaceans	crustacean	NNS
cord-016293-pyb00pt5	657	16	and	and	CC
cord-016293-pyb00pt5	657	17	determined	determine	VBD
cord-016293-pyb00pt5	657	18	its	-PRON-	PRP$
cord-016293-pyb00pt5	657	19	role	role	NN
cord-016293-pyb00pt5	657	20	in	in	IN
cord-016293-pyb00pt5	657	21	reproduction	reproduction	NN
cord-016293-pyb00pt5	657	22	,	,	,
cord-016293-pyb00pt5	657	23	researchers	researcher	NNS
cord-016293-pyb00pt5	657	24	at	at	IN
cord-016293-pyb00pt5	657	25	the	the	DT
cord-016293-pyb00pt5	657	26	University	University	NNP
cord-016293-pyb00pt5	657	27	of	of	IN
cord-016293-pyb00pt5	657	28	Connecticut	Connecticut	NNP
cord-016293-pyb00pt5	657	29	have	have	VBP
cord-016293-pyb00pt5	657	30	developed	develop	VBN
cord-016293-pyb00pt5	657	31	technology	technology	NN
cord-016293-pyb00pt5	657	32	to	to	TO
cord-016293-pyb00pt5	657	33	synchronize	synchronize	VB
cord-016293-pyb00pt5	657	34	shrimp	shrimp	NN
cord-016293-pyb00pt5	657	35	egg	egg	NN
cord-016293-pyb00pt5	657	36	production	production	NN
cord-016293-pyb00pt5	657	37	and	and	CC
cord-016293-pyb00pt5	657	38	to	to	TO
cord-016293-pyb00pt5	657	39	increase	increase	VB
cord-016293-pyb00pt5	657	40	the	the	DT
cord-016293-pyb00pt5	657	41	number	number	NN
cord-016293-pyb00pt5	657	42	and	and	CC
cord-016293-pyb00pt5	657	43	quality	quality	NN
cord-016293-pyb00pt5	657	44	of	of	IN
cord-016293-pyb00pt5	657	45	eggs	egg	NNS
cord-016293-pyb00pt5	657	46	produced	produce	VBN
cord-016293-pyb00pt5	657	47	.	.	.
cord-016293-pyb00pt5	658	1	Females	female	NNS
cord-016293-pyb00pt5	658	2	injected	inject	VBN
cord-016293-pyb00pt5	658	3	with	with	IN
cord-016293-pyb00pt5	658	4	MF	MF	NNP
cord-016293-pyb00pt5	658	5	are	be	VBP
cord-016293-pyb00pt5	658	6	stimulated	stimulate	VBN
cord-016293-pyb00pt5	658	7	to	to	TO
cord-016293-pyb00pt5	658	8	produce	produce	VB
cord-016293-pyb00pt5	658	9	eggs	egg	NNS
cord-016293-pyb00pt5	658	10	ready	ready	JJ
cord-016293-pyb00pt5	658	11	for	for	IN
cord-016293-pyb00pt5	658	12	fertilization	fertilization	NN
cord-016293-pyb00pt5	658	13	.	.	.
cord-016293-pyb00pt5	659	1	The	the	DT
cord-016293-pyb00pt5	659	2	procedure	procedure	NN
cord-016293-pyb00pt5	659	3	produces	produce	VBZ
cord-016293-pyb00pt5	659	4	180	180	CD
cord-016293-pyb00pt5	659	5	percent	percent	NN
cord-016293-pyb00pt5	659	6	more	more	JJR
cord-016293-pyb00pt5	659	7	eggs	egg	NNS
cord-016293-pyb00pt5	659	8	than	than	IN
cord-016293-pyb00pt5	659	9	the	the	DT
cord-016293-pyb00pt5	659	10	traditional	traditional	JJ
cord-016293-pyb00pt5	659	11	crude	crude	JJ
cord-016293-pyb00pt5	659	12	method	method	NN
cord-016293-pyb00pt5	659	13	of	of	IN
cord-016293-pyb00pt5	659	14	removing	remove	VBG
cord-016293-pyb00pt5	659	15	the	the	DT
cord-016293-pyb00pt5	659	16	eyestalk	eyestalk	NN
cord-016293-pyb00pt5	659	17	gland	gland	NN
cord-016293-pyb00pt5	659	18	.	.	.
cord-016293-pyb00pt5	660	1	This	this	DT
cord-016293-pyb00pt5	660	2	will	will	MD
cord-016293-pyb00pt5	660	3	increase	increase	VB
cord-016293-pyb00pt5	660	4	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	660	5	efficiency	efficiency	NN
cord-016293-pyb00pt5	660	6	.	.	.
cord-016293-pyb00pt5	661	1	A	a	DT
cord-016293-pyb00pt5	661	2	number	number	NN
cord-016293-pyb00pt5	661	3	of	of	IN
cord-016293-pyb00pt5	661	4	experiments	experiment	NNS
cord-016293-pyb00pt5	661	5	utilize	utilize	VBP
cord-016293-pyb00pt5	661	6	gene	gene	NN
cord-016293-pyb00pt5	661	7	transfer	transfer	NN
cord-016293-pyb00pt5	661	8	to	to	TO
cord-016293-pyb00pt5	661	9	develop	develop	VB
cord-016293-pyb00pt5	661	10	genetic	genetic	JJ
cord-016293-pyb00pt5	661	11	lines	line	NNS
cord-016293-pyb00pt5	661	12	of	of	IN
cord-016293-pyb00pt5	661	13	potential	potential	JJ
cord-016293-pyb00pt5	661	14	utility	utility	NN
cord-016293-pyb00pt5	661	15	in	in	IN
cord-016293-pyb00pt5	661	16	fisheries	fishery	NNS
cord-016293-pyb00pt5	661	17	management	management	NN
cord-016293-pyb00pt5	661	18	.	.	.
cord-016293-pyb00pt5	662	1	Transfer	transfer	NN
cord-016293-pyb00pt5	662	2	of	of	IN
cord-016293-pyb00pt5	662	3	GH	GH	NNP
cord-016293-pyb00pt5	662	4	genes	gene	NNS
cord-016293-pyb00pt5	662	5	into	into	IN
cord-016293-pyb00pt5	662	6	northern	northern	JJ
cord-016293-pyb00pt5	662	7	pike	pike	NN
cord-016293-pyb00pt5	662	8	,	,	,
cord-016293-pyb00pt5	662	9	walleye	walleye	NN
cord-016293-pyb00pt5	662	10	,	,	,
cord-016293-pyb00pt5	662	11	and	and	CC
cord-016293-pyb00pt5	662	12	largemouth	largemouth	NN
cord-016293-pyb00pt5	662	13	bass	bass	NN
cord-016293-pyb00pt5	662	14	are	be	VBP
cord-016293-pyb00pt5	662	15	aimed	aim	VBN
cord-016293-pyb00pt5	662	16	at	at	IN
cord-016293-pyb00pt5	662	17	improving	improve	VBG
cord-016293-pyb00pt5	662	18	the	the	DT
cord-016293-pyb00pt5	662	19	growth	growth	NN
cord-016293-pyb00pt5	662	20	rate	rate	NN
cord-016293-pyb00pt5	662	21	of	of	IN
cord-016293-pyb00pt5	662	22	sport	sport	NN
cord-016293-pyb00pt5	662	23	fishes	fish	NNS
cord-016293-pyb00pt5	662	24	.	.	.
cord-016293-pyb00pt5	663	1	Gene	gene	NN
cord-016293-pyb00pt5	663	2	transfer	transfer	NN
cord-016293-pyb00pt5	663	3	has	have	VBZ
cord-016293-pyb00pt5	663	4	been	be	VBN
cord-016293-pyb00pt5	663	5	posed	pose	VBN
cord-016293-pyb00pt5	663	6	as	as	IN
cord-016293-pyb00pt5	663	7	an	an	DT
cord-016293-pyb00pt5	663	8	option	option	NN
cord-016293-pyb00pt5	663	9	for	for	IN
cord-016293-pyb00pt5	663	10	reducing	reduce	VBG
cord-016293-pyb00pt5	663	11	losses	loss	NNS
cord-016293-pyb00pt5	663	12	of	of	IN
cord-016293-pyb00pt5	663	13	rainbow	rainbow	NN
cord-016293-pyb00pt5	663	14	trout	trout	NNS
cord-016293-pyb00pt5	663	15	to	to	IN
cord-016293-pyb00pt5	663	16	whirling	whirl	VBG
cord-016293-pyb00pt5	663	17	disease	disease	NN
cord-016293-pyb00pt5	663	18	,	,	,
cord-016293-pyb00pt5	663	19	although	although	IN
cord-016293-pyb00pt5	663	20	suitable	suitable	JJ
cord-016293-pyb00pt5	663	21	candidate	candidate	NN
cord-016293-pyb00pt5	663	22	genes	gene	NNS
cord-016293-pyb00pt5	663	23	have	have	VBP
cord-016293-pyb00pt5	663	24	yet	yet	RB
cord-016293-pyb00pt5	663	25	to	to	TO
cord-016293-pyb00pt5	663	26	be	be	VB
cord-016293-pyb00pt5	663	27	identified	identify	VBN
cord-016293-pyb00pt5	663	28	.	.	.
cord-016293-pyb00pt5	664	1	Richard	Richard	NNP
cord-016293-pyb00pt5	664	2	Winn	Winn	NNP
cord-016293-pyb00pt5	664	3	of	of	IN
cord-016293-pyb00pt5	664	4	the	the	DT
cord-016293-pyb00pt5	664	5	University	University	NNP
cord-016293-pyb00pt5	664	6	of	of	IN
cord-016293-pyb00pt5	664	7	Georgia	Georgia	NNP
cord-016293-pyb00pt5	664	8	is	be	VBZ
cord-016293-pyb00pt5	664	9	developing	develop	VBG
cord-016293-pyb00pt5	664	10	transgenic	transgenic	JJ
cord-016293-pyb00pt5	664	11	killifish	killifish	NN
cord-016293-pyb00pt5	664	12	and	and	CC
cord-016293-pyb00pt5	664	13	medaka	medaka	NN
cord-016293-pyb00pt5	664	14	as	as	IN
cord-016293-pyb00pt5	664	15	biomonitors	biomonitor	NNS
cord-016293-pyb00pt5	664	16	for	for	IN
cord-016293-pyb00pt5	664	17	environmental	environmental	JJ
cord-016293-pyb00pt5	664	18	mutagens	mutagen	NNS
cord-016293-pyb00pt5	664	19	,	,	,
cord-016293-pyb00pt5	664	20	which	which	WDT
cord-016293-pyb00pt5	664	21	carry	carry	VBP
cord-016293-pyb00pt5	664	22	the	the	DT
cord-016293-pyb00pt5	664	23	bacteriophage	bacteriophage	NN
cord-016293-pyb00pt5	664	24	phi	phi	NN
cord-016293-pyb00pt5	664	25	X	X	NNP
cord-016293-pyb00pt5	664	26	174	174	CD
cord-016293-pyb00pt5	664	27	as	as	IN
cord-016293-pyb00pt5	664	28	a	a	DT
cord-016293-pyb00pt5	664	29	target	target	NN
cord-016293-pyb00pt5	664	30	for	for	IN
cord-016293-pyb00pt5	664	31	mutation	mutation	NN
cord-016293-pyb00pt5	664	32	detection	detection	NN
cord-016293-pyb00pt5	664	33	.	.	.
cord-016293-pyb00pt5	665	1	Development	development	NN
cord-016293-pyb00pt5	665	2	of	of	IN
cord-016293-pyb00pt5	665	3	transgenic	transgenic	JJ
cord-016293-pyb00pt5	665	4	lines	line	NNS
cord-016293-pyb00pt5	665	5	for	for	IN
cord-016293-pyb00pt5	665	6	fisheries	fisheries	NN
cord-016293-pyb00pt5	665	7	management	management	NN
cord-016293-pyb00pt5	665	8	applications	application	NNS
cord-016293-pyb00pt5	665	9	generally	generally	RB
cord-016293-pyb00pt5	665	10	is	be	VBZ
cord-016293-pyb00pt5	665	11	at	at	IN
cord-016293-pyb00pt5	665	12	an	an	DT
cord-016293-pyb00pt5	665	13	early	early	JJ
cord-016293-pyb00pt5	665	14	stage	stage	NN
cord-016293-pyb00pt5	665	15	,	,	,
cord-016293-pyb00pt5	665	16	often	often	RB
cord-016293-pyb00pt5	665	17	at	at	IN
cord-016293-pyb00pt5	665	18	the	the	DT
cord-016293-pyb00pt5	665	19	founder	founder	NN
cord-016293-pyb00pt5	665	20	or	or	CC
cord-016293-pyb00pt5	665	21	F1	F1	NNP
cord-016293-pyb00pt5	665	22	generation	generation	NN
cord-016293-pyb00pt5	665	23	.	.	.
cord-016293-pyb00pt5	666	1	Broad	broad	JJ
cord-016293-pyb00pt5	666	2	application	application	NN
cord-016293-pyb00pt5	666	3	of	of	IN
cord-016293-pyb00pt5	666	4	transgenic	transgenic	JJ
cord-016293-pyb00pt5	666	5	aquatic	aquatic	JJ
cord-016293-pyb00pt5	666	6	organisms	organism	NNS
cord-016293-pyb00pt5	666	7	in	in	IN
cord-016293-pyb00pt5	666	8	aquaculture	aquaculture	NN
cord-016293-pyb00pt5	666	9	and	and	CC
cord-016293-pyb00pt5	666	10	fisheries	fishery	NNS
cord-016293-pyb00pt5	666	11	management	management	NN
cord-016293-pyb00pt5	666	12	will	will	MD
cord-016293-pyb00pt5	666	13	depend	depend	VB
cord-016293-pyb00pt5	666	14	on	on	IN
cord-016293-pyb00pt5	666	15	showing	show	VBG
cord-016293-pyb00pt5	666	16	that	that	IN
cord-016293-pyb00pt5	666	17	particular	particular	JJ
cord-016293-pyb00pt5	666	18	GMOs	GMOs	NNPS
cord-016293-pyb00pt5	666	19	can	can	MD
cord-016293-pyb00pt5	666	20	be	be	VB
cord-016293-pyb00pt5	666	21	used	use	VBN
cord-016293-pyb00pt5	666	22	in	in	IN
cord-016293-pyb00pt5	666	23	the	the	DT
cord-016293-pyb00pt5	666	24	environment	environment	NN
cord-016293-pyb00pt5	666	25	both	both	CC
cord-016293-pyb00pt5	666	26	effectively	effectively	RB
cord-016293-pyb00pt5	666	27	and	and	CC
cord-016293-pyb00pt5	666	28	safely	safely	RB
cord-016293-pyb00pt5	666	29	.	.	.
cord-016293-pyb00pt5	667	1	Although	although	IN
cord-016293-pyb00pt5	667	2	our	-PRON-	PRP$
cord-016293-pyb00pt5	667	3	base	base	NN
cord-016293-pyb00pt5	667	4	of	of	IN
cord-016293-pyb00pt5	667	5	knowledge	knowledge	NN
cord-016293-pyb00pt5	667	6	for	for	IN
cord-016293-pyb00pt5	667	7	assessing	assess	VBG
cord-016293-pyb00pt5	667	8	ecological	ecological	JJ
cord-016293-pyb00pt5	667	9	and	and	CC
cord-016293-pyb00pt5	667	10	genetic	genetic	JJ
cord-016293-pyb00pt5	667	11	safety	safety	NN
cord-016293-pyb00pt5	667	12	of	of	IN
cord-016293-pyb00pt5	667	13	aquatic	aquatic	JJ
cord-016293-pyb00pt5	667	14	GMOs	GMOs	NNPS
cord-016293-pyb00pt5	667	15	currently	currently	RB
cord-016293-pyb00pt5	667	16	is	be	VBZ
cord-016293-pyb00pt5	667	17	limited	limit	VBN
cord-016293-pyb00pt5	667	18	,	,	,
cord-016293-pyb00pt5	667	19	some	some	DT
cord-016293-pyb00pt5	667	20	early	early	JJ
cord-016293-pyb00pt5	667	21	studies	study	NNS
cord-016293-pyb00pt5	667	22	supported	support	VBN
cord-016293-pyb00pt5	667	23	by	by	IN
cord-016293-pyb00pt5	667	24	the	the	DT
cord-016293-pyb00pt5	667	25	USDA	USDA	NNP
cord-016293-pyb00pt5	667	26	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	667	27	risk	risk	NN
cord-016293-pyb00pt5	667	28	assessment	assessment	NN
cord-016293-pyb00pt5	667	29	program	program	NN
cord-016293-pyb00pt5	667	30	have	have	VBP
cord-016293-pyb00pt5	667	31	yielded	yield	VBN
cord-016293-pyb00pt5	667	32	results	result	NNS
cord-016293-pyb00pt5	667	33	.	.	.
cord-016293-pyb00pt5	668	1	Data	datum	NNS
cord-016293-pyb00pt5	668	2	from	from	IN
cord-016293-pyb00pt5	668	3	outdoor	outdoor	JJ
cord-016293-pyb00pt5	668	4	pond	pond	NN
cord-016293-pyb00pt5	668	5	-	-	HYPH
cord-016293-pyb00pt5	668	6	based	base	VBN
cord-016293-pyb00pt5	668	7	studies	study	NNS
cord-016293-pyb00pt5	668	8	on	on	IN
cord-016293-pyb00pt5	668	9	transgenic	transgenic	JJ
cord-016293-pyb00pt5	668	10	catfish	catfish	NNS
cord-016293-pyb00pt5	668	11	reported	report	VBN
cord-016293-pyb00pt5	668	12	by	by	IN
cord-016293-pyb00pt5	668	13	Rex	Rex	NNP
cord-016293-pyb00pt5	668	14	Dunham	Dunham	NNP
cord-016293-pyb00pt5	668	15	of	of	IN
cord-016293-pyb00pt5	668	16	Auburn	Auburn	NNP
cord-016293-pyb00pt5	668	17	University	University	NNP
cord-016293-pyb00pt5	668	18	show	show	VBP
cord-016293-pyb00pt5	668	19	that	that	IN
cord-016293-pyb00pt5	668	20	transgenic	transgenic	JJ
cord-016293-pyb00pt5	668	21	and	and	CC
cord-016293-pyb00pt5	668	22	non	non	JJ
cord-016293-pyb00pt5	668	23	-	-	JJ
cord-016293-pyb00pt5	668	24	transgenic	transgenic	JJ
cord-016293-pyb00pt5	668	25	individuals	individual	NNS
cord-016293-pyb00pt5	668	26	interbreed	interbreed	VBP
cord-016293-pyb00pt5	668	27	freely	freely	RB
cord-016293-pyb00pt5	668	28	,	,	,
cord-016293-pyb00pt5	668	29	that	that	IN
cord-016293-pyb00pt5	668	30	survival	survival	NN
cord-016293-pyb00pt5	668	31	and	and	CC
cord-016293-pyb00pt5	668	32	growth	growth	NN
cord-016293-pyb00pt5	668	33	of	of	IN
cord-016293-pyb00pt5	668	34	transgenics	transgenic	NNS
cord-016293-pyb00pt5	668	35	in	in	IN
cord-016293-pyb00pt5	668	36	unfed	unfed	JJ
cord-016293-pyb00pt5	668	37	ponds	pond	NNS
cord-016293-pyb00pt5	668	38	was	be	VBD
cord-016293-pyb00pt5	668	39	equal	equal	JJ
cord-016293-pyb00pt5	668	40	to	to	IN
cord-016293-pyb00pt5	668	41	or	or	CC
cord-016293-pyb00pt5	668	42	less	less	JJR
cord-016293-pyb00pt5	668	43	than	than	IN
cord-016293-pyb00pt5	668	44	that	that	DT
cord-016293-pyb00pt5	668	45	of	of	IN
cord-016293-pyb00pt5	668	46	non	non	JJ
cord-016293-pyb00pt5	668	47	-	-	NNS
cord-016293-pyb00pt5	668	48	transgenics	transgenic	NNS
cord-016293-pyb00pt5	668	49	,	,	,
cord-016293-pyb00pt5	668	50	and	and	CC
cord-016293-pyb00pt5	668	51	that	that	IN
cord-016293-pyb00pt5	668	52	predator	predator	NN
cord-016293-pyb00pt5	668	53	avoidance	avoidance	NN
cord-016293-pyb00pt5	668	54	is	be	VBZ
cord-016293-pyb00pt5	668	55	not	not	RB
cord-016293-pyb00pt5	668	56	affected	affect	VBN
cord-016293-pyb00pt5	668	57	by	by	IN
cord-016293-pyb00pt5	668	58	expression	expression	NN
cord-016293-pyb00pt5	668	59	of	of	IN
cord-016293-pyb00pt5	668	60	the	the	DT
cord-016293-pyb00pt5	668	61	transgene	transgene	NN
cord-016293-pyb00pt5	668	62	.	.	.
cord-016293-pyb00pt5	669	1	However	however	RB
cord-016293-pyb00pt5	669	2	,	,	,
cord-016293-pyb00pt5	669	3	unquestionably	unquestionably	RB
cord-016293-pyb00pt5	669	4	the	the	DT
cord-016293-pyb00pt5	669	5	seminal	seminal	JJ
cord-016293-pyb00pt5	669	6	event	event	NN
cord-016293-pyb00pt5	669	7	for	for	IN
cord-016293-pyb00pt5	669	8	animal	animal	NN
cord-016293-pyb00pt5	669	9	biotech	biotech	NN
cord-016293-pyb00pt5	669	10	in	in	IN
cord-016293-pyb00pt5	669	11	the	the	DT
cord-016293-pyb00pt5	669	12	nineties	ninety	NNS
cord-016293-pyb00pt5	669	13	was	be	VBD
cord-016293-pyb00pt5	669	14	Ian	Ian	NNP
cord-016293-pyb00pt5	669	15	Wilmut	Wilmut	NNP
cord-016293-pyb00pt5	669	16	's	's	POS
cord-016293-pyb00pt5	669	17	landmark	landmark	NN
cord-016293-pyb00pt5	669	18	work	work	NN
cord-016293-pyb00pt5	669	19	using	use	VBG
cord-016293-pyb00pt5	669	20	nuclear	nuclear	JJ
cord-016293-pyb00pt5	669	21	transfer	transfer	NN
cord-016293-pyb00pt5	669	22	technology	technology	NN
cord-016293-pyb00pt5	669	23	to	to	TO
cord-016293-pyb00pt5	669	24	generate	generate	VB
cord-016293-pyb00pt5	669	25	the	the	DT
cord-016293-pyb00pt5	669	26	lambs	lamb	NNS
cord-016293-pyb00pt5	669	27	Morag	Morag	NNP
cord-016293-pyb00pt5	669	28	and	and	CC
cord-016293-pyb00pt5	669	29	Megan	Megan	NNP
cord-016293-pyb00pt5	669	30	reported	report	VBD
cord-016293-pyb00pt5	669	31	in	in	IN
cord-016293-pyb00pt5	669	32	1996	1996	CD
cord-016293-pyb00pt5	669	33	(	(	-LRB-
cord-016293-pyb00pt5	669	34	from	from	IN
cord-016293-pyb00pt5	669	35	an	an	DT
cord-016293-pyb00pt5	669	36	embryonic	embryonic	JJ
cord-016293-pyb00pt5	669	37	cell	cell	NN
cord-016293-pyb00pt5	669	38	nuclei	nucleus	NNS
cord-016293-pyb00pt5	669	39	)	)	-RRB-
cord-016293-pyb00pt5	669	40	and	and	CC
cord-016293-pyb00pt5	669	41	the	the	DT
cord-016293-pyb00pt5	669	42	truly	truly	RB
cord-016293-pyb00pt5	669	43	ground	ground	NN
cord-016293-pyb00pt5	669	44	-	-	HYPH
cord-016293-pyb00pt5	669	45	breaking	break	VBG
cord-016293-pyb00pt5	669	46	work	work	NN
cord-016293-pyb00pt5	669	47	of	of	IN
cord-016293-pyb00pt5	669	48	creating	create	VBG
cord-016293-pyb00pt5	669	49	Dolly	Dolly	NNP
cord-016293-pyb00pt5	669	50	from	from	IN
cord-016293-pyb00pt5	669	51	an	an	DT
cord-016293-pyb00pt5	669	52	adult	adult	NN
cord-016293-pyb00pt5	669	53	somatic	somatic	JJ
cord-016293-pyb00pt5	669	54	cell	cell	NN
cord-016293-pyb00pt5	669	55	nucleus	nucleus	NN
cord-016293-pyb00pt5	669	56	,	,	,
cord-016293-pyb00pt5	669	57	reported	report	VBN
cord-016293-pyb00pt5	669	58	in	in	IN
cord-016293-pyb00pt5	669	59	February	February	NNP
cord-016293-pyb00pt5	669	60	,	,	,
cord-016293-pyb00pt5	669	61	1997	1997	CD
cord-016293-pyb00pt5	669	62	(	(	-LRB-
cord-016293-pyb00pt5	669	63	Wilmut	Wilmut	NNP
cord-016293-pyb00pt5	669	64	,	,	,
cord-016293-pyb00pt5	669	65	1997	1997	CD
cord-016293-pyb00pt5	669	66	)	)	-RRB-
cord-016293-pyb00pt5	669	67	.	.	.
cord-016293-pyb00pt5	670	1	Wilmut	Wilmut	NNP
cord-016293-pyb00pt5	670	2	and	and	CC
cord-016293-pyb00pt5	670	3	his	-PRON-	PRP$
cord-016293-pyb00pt5	670	4	colleagues	colleague	NNS
cord-016293-pyb00pt5	670	5	at	at	IN
cord-016293-pyb00pt5	670	6	the	the	DT
cord-016293-pyb00pt5	670	7	Roslin	Roslin	NNP
cord-016293-pyb00pt5	670	8	Institute	Institute	NNP
cord-016293-pyb00pt5	670	9	demonstrated	demonstrate	VBD
cord-016293-pyb00pt5	670	10	for	for	IN
cord-016293-pyb00pt5	670	11	the	the	DT
cord-016293-pyb00pt5	670	12	first	first	JJ
cord-016293-pyb00pt5	670	13	time	time	NN
cord-016293-pyb00pt5	670	14	with	with	IN
cord-016293-pyb00pt5	670	15	the	the	DT
cord-016293-pyb00pt5	670	16	birth	birth	NN
cord-016293-pyb00pt5	670	17	of	of	IN
cord-016293-pyb00pt5	670	18	Dolly	Dolly	NNP
cord-016293-pyb00pt5	670	19	the	the	DT
cord-016293-pyb00pt5	670	20	sheep	sheep	NN
cord-016293-pyb00pt5	670	21	that	that	WDT
cord-016293-pyb00pt5	670	22	the	the	DT
cord-016293-pyb00pt5	670	23	nucleus	nucleus	NN
cord-016293-pyb00pt5	670	24	of	of	IN
cord-016293-pyb00pt5	670	25	an	an	DT
cord-016293-pyb00pt5	670	26	adult	adult	NN
cord-016293-pyb00pt5	670	27	somatic	somatic	JJ
cord-016293-pyb00pt5	670	28	cell	cell	NN
cord-016293-pyb00pt5	670	29	can	can	MD
cord-016293-pyb00pt5	670	30	be	be	VB
cord-016293-pyb00pt5	670	31	transferred	transfer	VBN
cord-016293-pyb00pt5	670	32	to	to	IN
cord-016293-pyb00pt5	670	33	an	an	DT
cord-016293-pyb00pt5	670	34	enucleated	enucleated	JJ
cord-016293-pyb00pt5	670	35	egg	egg	NN
cord-016293-pyb00pt5	670	36	to	to	TO
cord-016293-pyb00pt5	670	37	create	create	VB
cord-016293-pyb00pt5	670	38	cloned	clone	VBN
cord-016293-pyb00pt5	670	39	offspring	offspring	NN
cord-016293-pyb00pt5	670	40	.	.	.
cord-016293-pyb00pt5	671	1	It	-PRON-	PRP
cord-016293-pyb00pt5	671	2	had	have	VBD
cord-016293-pyb00pt5	671	3	been	be	VBN
cord-016293-pyb00pt5	671	4	assumed	assume	VBN
cord-016293-pyb00pt5	671	5	for	for	IN
cord-016293-pyb00pt5	671	6	some	some	DT
cord-016293-pyb00pt5	671	7	time	time	NN
cord-016293-pyb00pt5	671	8	that	that	IN
cord-016293-pyb00pt5	671	9	only	only	JJ
cord-016293-pyb00pt5	671	10	embryonic	embryonic	JJ
cord-016293-pyb00pt5	671	11	cells	cell	NNS
cord-016293-pyb00pt5	671	12	could	could	MD
cord-016293-pyb00pt5	671	13	be	be	VB
cord-016293-pyb00pt5	671	14	used	use	VBN
cord-016293-pyb00pt5	671	15	as	as	IN
cord-016293-pyb00pt5	671	16	the	the	DT
cord-016293-pyb00pt5	671	17	cellular	cellular	JJ
cord-016293-pyb00pt5	671	18	source	source	NN
cord-016293-pyb00pt5	671	19	for	for	IN
cord-016293-pyb00pt5	671	20	nuclear	nuclear	JJ
cord-016293-pyb00pt5	671	21	transfer	transfer	NN
cord-016293-pyb00pt5	671	22	.	.	.
cord-016293-pyb00pt5	672	1	This	this	DT
cord-016293-pyb00pt5	672	2	assumption	assumption	NN
cord-016293-pyb00pt5	672	3	was	be	VBD
cord-016293-pyb00pt5	672	4	shattered	shatter	VBN
cord-016293-pyb00pt5	672	5	with	with	IN
cord-016293-pyb00pt5	672	6	the	the	DT
cord-016293-pyb00pt5	672	7	birth	birth	NN
cord-016293-pyb00pt5	672	8	of	of	IN
cord-016293-pyb00pt5	672	9	Dolly	Dolly	NNP
cord-016293-pyb00pt5	672	10	.	.	.
cord-016293-pyb00pt5	673	1	This	this	DT
cord-016293-pyb00pt5	673	2	example	example	NN
cord-016293-pyb00pt5	673	3	of	of	IN
cord-016293-pyb00pt5	673	4	cloning	clone	VBG
cord-016293-pyb00pt5	673	5	an	an	DT
cord-016293-pyb00pt5	673	6	animal	animal	NN
cord-016293-pyb00pt5	673	7	using	use	VBG
cord-016293-pyb00pt5	673	8	the	the	DT
cord-016293-pyb00pt5	673	9	nucleus	nucleus	NN
cord-016293-pyb00pt5	673	10	of	of	IN
cord-016293-pyb00pt5	673	11	an	an	DT
cord-016293-pyb00pt5	673	12	adult	adult	NN
cord-016293-pyb00pt5	673	13	cell	cell	NN
cord-016293-pyb00pt5	673	14	was	be	VBD
cord-016293-pyb00pt5	673	15	significant	significant	JJ
cord-016293-pyb00pt5	673	16	because	because	IN
cord-016293-pyb00pt5	673	17	it	-PRON-	PRP
cord-016293-pyb00pt5	673	18	demonstrated	demonstrate	VBD
cord-016293-pyb00pt5	673	19	the	the	DT
cord-016293-pyb00pt5	673	20	ability	ability	NN
cord-016293-pyb00pt5	673	21	of	of	IN
cord-016293-pyb00pt5	673	22	egg	egg	NN
cord-016293-pyb00pt5	673	23	cell	cell	NN
cord-016293-pyb00pt5	673	24	cytoplasm	cytoplasm	NN
cord-016293-pyb00pt5	673	25	to	to	IN
cord-016293-pyb00pt5	673	26	"	"	``
cord-016293-pyb00pt5	673	27	reprogram	reprogram	VB
cord-016293-pyb00pt5	673	28	"	"	''
cord-016293-pyb00pt5	673	29	an	an	DT
cord-016293-pyb00pt5	673	30	adult	adult	NN
cord-016293-pyb00pt5	673	31	nucleus	nucleus	NN
cord-016293-pyb00pt5	673	32	.	.	.
cord-016293-pyb00pt5	674	1	When	when	WRB
cord-016293-pyb00pt5	674	2	cells	cell	NNS
cord-016293-pyb00pt5	674	3	differentiate	differentiate	VBP
cord-016293-pyb00pt5	674	4	,	,	,
cord-016293-pyb00pt5	674	5	that	that	RB
cord-016293-pyb00pt5	674	6	is	is	RB
cord-016293-pyb00pt5	674	7	,	,	,
cord-016293-pyb00pt5	674	8	evolve	evolve	VBP
cord-016293-pyb00pt5	674	9	from	from	IN
cord-016293-pyb00pt5	674	10	primitive	primitive	JJ
cord-016293-pyb00pt5	674	11	embryonic	embryonic	JJ
cord-016293-pyb00pt5	674	12	cells	cell	NNS
cord-016293-pyb00pt5	674	13	to	to	IN
cord-016293-pyb00pt5	674	14	functionally	functionally	RB
cord-016293-pyb00pt5	674	15	defined	define	VBN
cord-016293-pyb00pt5	674	16	adult	adult	NN
cord-016293-pyb00pt5	674	17	cells	cell	NNS
cord-016293-pyb00pt5	674	18	,	,	,
cord-016293-pyb00pt5	674	19	they	-PRON-	PRP
cord-016293-pyb00pt5	674	20	lose	lose	VBP
cord-016293-pyb00pt5	674	21	the	the	DT
cord-016293-pyb00pt5	674	22	ability	ability	NN
cord-016293-pyb00pt5	674	23	to	to	TO
cord-016293-pyb00pt5	674	24	express	express	VB
cord-016293-pyb00pt5	674	25	most	most	JJS
cord-016293-pyb00pt5	674	26	genes	gene	NNS
cord-016293-pyb00pt5	674	27	and	and	CC
cord-016293-pyb00pt5	674	28	can	can	MD
cord-016293-pyb00pt5	674	29	only	only	RB
cord-016293-pyb00pt5	674	30	express	express	VB
cord-016293-pyb00pt5	674	31	those	those	DT
cord-016293-pyb00pt5	674	32	genes	gene	NNS
cord-016293-pyb00pt5	674	33	necessary	necessary	JJ
cord-016293-pyb00pt5	674	34	for	for	IN
cord-016293-pyb00pt5	674	35	the	the	DT
cord-016293-pyb00pt5	674	36	cell	cell	NN
cord-016293-pyb00pt5	674	37	's	's	POS
cord-016293-pyb00pt5	674	38	differentiated	differentiated	JJ
cord-016293-pyb00pt5	674	39	function	function	NN
cord-016293-pyb00pt5	674	40	.	.	.
cord-016293-pyb00pt5	675	1	For	for	IN
cord-016293-pyb00pt5	675	2	example	example	NN
cord-016293-pyb00pt5	675	3	,	,	,
cord-016293-pyb00pt5	675	4	skin	skin	NN
cord-016293-pyb00pt5	675	5	cells	cell	NNS
cord-016293-pyb00pt5	675	6	only	only	RB
cord-016293-pyb00pt5	675	7	express	express	VBP
cord-016293-pyb00pt5	675	8	genes	gene	NNS
cord-016293-pyb00pt5	675	9	necessary	necessary	JJ
cord-016293-pyb00pt5	675	10	for	for	IN
cord-016293-pyb00pt5	675	11	skin	skin	NN
cord-016293-pyb00pt5	675	12	function	function	NN
cord-016293-pyb00pt5	675	13	,	,	,
cord-016293-pyb00pt5	675	14	and	and	CC
cord-016293-pyb00pt5	675	15	brain	brain	NN
cord-016293-pyb00pt5	675	16	cells	cell	NNS
cord-016293-pyb00pt5	675	17	only	only	RB
cord-016293-pyb00pt5	675	18	express	express	VBP
cord-016293-pyb00pt5	675	19	genes	gene	NNS
cord-016293-pyb00pt5	675	20	necessary	necessary	JJ
cord-016293-pyb00pt5	675	21	for	for	IN
cord-016293-pyb00pt5	675	22	brain	brain	NN
cord-016293-pyb00pt5	675	23	function	function	NN
cord-016293-pyb00pt5	675	24	.	.	.
cord-016293-pyb00pt5	676	1	The	the	DT
cord-016293-pyb00pt5	676	2	procedure	procedure	NN
cord-016293-pyb00pt5	676	3	that	that	WDT
cord-016293-pyb00pt5	676	4	produced	produce	VBD
cord-016293-pyb00pt5	676	5	Dolly	Dolly	NNP
cord-016293-pyb00pt5	676	6	demonstrated	demonstrate	VBD
cord-016293-pyb00pt5	676	7	that	that	IN
cord-016293-pyb00pt5	676	8	egg	egg	NN
cord-016293-pyb00pt5	676	9	cytoplasm	cytoplasm	NN
cord-016293-pyb00pt5	676	10	is	be	VBZ
cord-016293-pyb00pt5	676	11	capable	capable	JJ
cord-016293-pyb00pt5	676	12	of	of	IN
cord-016293-pyb00pt5	676	13	reprogramming	reprogramme	VBG
cord-016293-pyb00pt5	676	14	an	an	DT
cord-016293-pyb00pt5	676	15	adult	adult	NN
cord-016293-pyb00pt5	676	16	differentiated	differentiated	JJ
cord-016293-pyb00pt5	676	17	cell	cell	NN
cord-016293-pyb00pt5	676	18	(	(	-LRB-
cord-016293-pyb00pt5	676	19	which	which	WDT
cord-016293-pyb00pt5	676	20	is	be	VBZ
cord-016293-pyb00pt5	676	21	only	only	RB
cord-016293-pyb00pt5	676	22	expressing	express	VBG
cord-016293-pyb00pt5	676	23	genes	gene	NNS
cord-016293-pyb00pt5	676	24	related	relate	VBN
cord-016293-pyb00pt5	676	25	to	to	IN
cord-016293-pyb00pt5	676	26	the	the	DT
cord-016293-pyb00pt5	676	27	function	function	NN
cord-016293-pyb00pt5	676	28	of	of	IN
cord-016293-pyb00pt5	676	29	that	that	DT
cord-016293-pyb00pt5	676	30	cell	cell	NN
cord-016293-pyb00pt5	676	31	type	type	NN
cord-016293-pyb00pt5	676	32	)	)	-RRB-
cord-016293-pyb00pt5	676	33	.	.	.
cord-016293-pyb00pt5	677	1	This	this	DT
cord-016293-pyb00pt5	677	2	reprogramming	reprogramming	NN
cord-016293-pyb00pt5	677	3	enables	enable	VBZ
cord-016293-pyb00pt5	677	4	the	the	DT
cord-016293-pyb00pt5	677	5	differentiated	differentiated	JJ
cord-016293-pyb00pt5	677	6	cell	cell	NN
cord-016293-pyb00pt5	677	7	nucleus	nucleus	NN
cord-016293-pyb00pt5	677	8	to	to	IN
cord-016293-pyb00pt5	677	9	once	once	RB
cord-016293-pyb00pt5	677	10	again	again	RB
cord-016293-pyb00pt5	677	11	express	express	VB
cord-016293-pyb00pt5	677	12	all	all	PDT
cord-016293-pyb00pt5	677	13	the	the	DT
cord-016293-pyb00pt5	677	14	genes	gene	NNS
cord-016293-pyb00pt5	677	15	required	require	VBN
cord-016293-pyb00pt5	677	16	for	for	IN
cord-016293-pyb00pt5	677	17	the	the	DT
cord-016293-pyb00pt5	677	18	full	full	JJ
cord-016293-pyb00pt5	677	19	embryonic	embryonic	JJ
cord-016293-pyb00pt5	677	20	development	development	NN
cord-016293-pyb00pt5	677	21	of	of	IN
cord-016293-pyb00pt5	677	22	the	the	DT
cord-016293-pyb00pt5	677	23	adult	adult	NN
cord-016293-pyb00pt5	677	24	animal	animal	NN
cord-016293-pyb00pt5	677	25	.	.	.
cord-016293-pyb00pt5	678	1	Since	since	IN
cord-016293-pyb00pt5	678	2	Dolly	Dolly	NNP
cord-016293-pyb00pt5	678	3	was	be	VBD
cord-016293-pyb00pt5	678	4	cloned	clone	VBN
cord-016293-pyb00pt5	678	5	,	,	,
cord-016293-pyb00pt5	678	6	similar	similar	JJ
cord-016293-pyb00pt5	678	7	techniques	technique	NNS
cord-016293-pyb00pt5	678	8	have	have	VBP
cord-016293-pyb00pt5	678	9	been	be	VBN
cord-016293-pyb00pt5	678	10	used	use	VBN
cord-016293-pyb00pt5	678	11	to	to	TO
cord-016293-pyb00pt5	678	12	clone	clone	VB
cord-016293-pyb00pt5	678	13	a	a	DT
cord-016293-pyb00pt5	678	14	veritable	veritable	JJ
cord-016293-pyb00pt5	678	15	zoo	zoo	NN
cord-016293-pyb00pt5	678	16	of	of	IN
cord-016293-pyb00pt5	678	17	vertebrates	vertebrate	NNS
cord-016293-pyb00pt5	678	18	including	include	VBG
cord-016293-pyb00pt5	678	19	mice	mouse	NNS
cord-016293-pyb00pt5	678	20	,	,	,
cord-016293-pyb00pt5	678	21	cattle	cattle	NNS
cord-016293-pyb00pt5	678	22	,	,	,
cord-016293-pyb00pt5	678	23	rabbitts	rabbitt	NNS
cord-016293-pyb00pt5	678	24	,	,	,
cord-016293-pyb00pt5	678	25	mules	mule	NNS
cord-016293-pyb00pt5	678	26	,	,	,
cord-016293-pyb00pt5	678	27	horses	horse	NNS
cord-016293-pyb00pt5	678	28	,	,	,
cord-016293-pyb00pt5	678	29	fish	fish	NN
cord-016293-pyb00pt5	678	30	,	,	,
cord-016293-pyb00pt5	678	31	cats	cat	NNS
cord-016293-pyb00pt5	678	32	and	and	CC
cord-016293-pyb00pt5	678	33	dogs	dog	NNS
cord-016293-pyb00pt5	678	34	from	from	IN
cord-016293-pyb00pt5	678	35	donor	donor	NN
cord-016293-pyb00pt5	678	36	cells	cell	NNS
cord-016293-pyb00pt5	678	37	obtained	obtain	VBN
cord-016293-pyb00pt5	678	38	from	from	IN
cord-016293-pyb00pt5	678	39	adult	adult	NN
cord-016293-pyb00pt5	678	40	animals	animal	NNS
cord-016293-pyb00pt5	678	41	.	.	.
cord-016293-pyb00pt5	679	1	These	these	DT
cord-016293-pyb00pt5	679	2	spectacular	spectacular	JJ
cord-016293-pyb00pt5	679	3	examples	example	NNS
cord-016293-pyb00pt5	679	4	of	of	IN
cord-016293-pyb00pt5	679	5	cloning	clone	VBG
cord-016293-pyb00pt5	679	6	normal	normal	JJ
cord-016293-pyb00pt5	679	7	animals	animal	NNS
cord-016293-pyb00pt5	679	8	from	from	IN
cord-016293-pyb00pt5	679	9	fully	fully	RB
cord-016293-pyb00pt5	679	10	differentiated	differentiate	VBN
cord-016293-pyb00pt5	679	11	adult	adult	NN
cord-016293-pyb00pt5	679	12	cells	cell	NNS
cord-016293-pyb00pt5	679	13	demonstrate	demonstrate	VBP
cord-016293-pyb00pt5	679	14	the	the	DT
cord-016293-pyb00pt5	679	15	universality	universality	NN
cord-016293-pyb00pt5	679	16	of	of	IN
cord-016293-pyb00pt5	679	17	nuclear	nuclear	JJ
cord-016293-pyb00pt5	679	18	reprogramming	reprogramming	NN
cord-016293-pyb00pt5	679	19	although	although	IN
cord-016293-pyb00pt5	679	20	the	the	DT
cord-016293-pyb00pt5	679	21	next	next	JJ
cord-016293-pyb00pt5	679	22	decade	decade	NN
cord-016293-pyb00pt5	679	23	called	call	VBN
cord-016293-pyb00pt5	679	24	some	some	DT
cord-016293-pyb00pt5	679	25	of	of	IN
cord-016293-pyb00pt5	679	26	these	these	DT
cord-016293-pyb00pt5	679	27	assumptions	assumption	NNS
cord-016293-pyb00pt5	679	28	into	into	IN
cord-016293-pyb00pt5	679	29	question	question	NN
cord-016293-pyb00pt5	679	30	.	.	.
cord-016293-pyb00pt5	680	1	This	this	DT
cord-016293-pyb00pt5	680	2	technology	technology	NN
cord-016293-pyb00pt5	680	3	supports	support	VBZ
cord-016293-pyb00pt5	680	4	the	the	DT
cord-016293-pyb00pt5	680	5	production	production	NN
cord-016293-pyb00pt5	680	6	of	of	IN
cord-016293-pyb00pt5	680	7	genetically	genetically	RB
cord-016293-pyb00pt5	680	8	identical	identical	JJ
cord-016293-pyb00pt5	680	9	and	and	CC
cord-016293-pyb00pt5	680	10	genetically	genetically	RB
cord-016293-pyb00pt5	680	11	modified	modify	VBN
cord-016293-pyb00pt5	680	12	animals	animal	NNS
cord-016293-pyb00pt5	680	13	.	.	.
cord-016293-pyb00pt5	681	1	Thus	thus	RB
cord-016293-pyb00pt5	681	2	,	,	,
cord-016293-pyb00pt5	681	3	the	the	DT
cord-016293-pyb00pt5	681	4	successful	successful	JJ
cord-016293-pyb00pt5	681	5	"	"	``
cord-016293-pyb00pt5	681	6	cloning	clone	VBG
cord-016293-pyb00pt5	681	7	"	"	''
cord-016293-pyb00pt5	681	8	of	of	IN
cord-016293-pyb00pt5	681	9	Dolly	Dolly	NNP
cord-016293-pyb00pt5	681	10	has	have	VBZ
cord-016293-pyb00pt5	681	11	captured	capture	VBN
cord-016293-pyb00pt5	681	12	the	the	DT
cord-016293-pyb00pt5	681	13	imagination	imagination	NN
cord-016293-pyb00pt5	681	14	of	of	IN
cord-016293-pyb00pt5	681	15	researchers	researcher	NNS
cord-016293-pyb00pt5	681	16	around	around	IN
cord-016293-pyb00pt5	681	17	the	the	DT
cord-016293-pyb00pt5	681	18	world	world	NN
cord-016293-pyb00pt5	681	19	.	.	.
cord-016293-pyb00pt5	682	1	This	this	DT
cord-016293-pyb00pt5	682	2	technological	technological	JJ
cord-016293-pyb00pt5	682	3	breakthrough	breakthrough	NN
cord-016293-pyb00pt5	682	4	should	should	MD
cord-016293-pyb00pt5	682	5	play	play	VB
cord-016293-pyb00pt5	682	6	a	a	DT
cord-016293-pyb00pt5	682	7	significant	significant	JJ
cord-016293-pyb00pt5	682	8	role	role	NN
cord-016293-pyb00pt5	682	9	in	in	IN
cord-016293-pyb00pt5	682	10	the	the	DT
cord-016293-pyb00pt5	682	11	development	development	NN
cord-016293-pyb00pt5	682	12	of	of	IN
cord-016293-pyb00pt5	682	13	new	new	JJ
cord-016293-pyb00pt5	682	14	procedures	procedure	NNS
cord-016293-pyb00pt5	682	15	for	for	IN
cord-016293-pyb00pt5	682	16	genetic	genetic	JJ
cord-016293-pyb00pt5	682	17	engineering	engineering	NN
cord-016293-pyb00pt5	682	18	in	in	IN
cord-016293-pyb00pt5	682	19	a	a	DT
cord-016293-pyb00pt5	682	20	number	number	NN
cord-016293-pyb00pt5	682	21	of	of	IN
cord-016293-pyb00pt5	682	22	mammalian	mammalian	JJ
cord-016293-pyb00pt5	682	23	species	specie	NNS
cord-016293-pyb00pt5	682	24	.	.	.
cord-016293-pyb00pt5	683	1	It	-PRON-	PRP
cord-016293-pyb00pt5	683	2	should	should	MD
cord-016293-pyb00pt5	683	3	be	be	VB
cord-016293-pyb00pt5	683	4	noted	note	VBN
cord-016293-pyb00pt5	683	5	that	that	IN
cord-016293-pyb00pt5	683	6	nuclear	nuclear	JJ
cord-016293-pyb00pt5	683	7	cloning	cloning	NN
cord-016293-pyb00pt5	683	8	,	,	,
cord-016293-pyb00pt5	683	9	with	with	IN
cord-016293-pyb00pt5	683	10	nuclei	nucleus	NNS
cord-016293-pyb00pt5	683	11	obtained	obtain	VBN
cord-016293-pyb00pt5	683	12	from	from	IN
cord-016293-pyb00pt5	683	13	either	either	DT
cord-016293-pyb00pt5	683	14	mammalian	mammalian	JJ
cord-016293-pyb00pt5	683	15	stem	stem	NN
cord-016293-pyb00pt5	683	16	cells	cell	NNS
cord-016293-pyb00pt5	683	17	or	or	CC
cord-016293-pyb00pt5	683	18	differentiated	differentiate	VBN
cord-016293-pyb00pt5	683	19	"	"	``
cord-016293-pyb00pt5	683	20	adult	adult	NN
cord-016293-pyb00pt5	683	21	"	"	''
cord-016293-pyb00pt5	683	22	cells	cell	NNS
cord-016293-pyb00pt5	683	23	,	,	,
cord-016293-pyb00pt5	683	24	is	be	VBZ
cord-016293-pyb00pt5	683	25	an	an	DT
cord-016293-pyb00pt5	683	26	especially	especially	RB
cord-016293-pyb00pt5	683	27	important	important	JJ
cord-016293-pyb00pt5	683	28	development	development	NN
cord-016293-pyb00pt5	683	29	for	for	IN
cord-016293-pyb00pt5	683	30	transgenic	transgenic	JJ
cord-016293-pyb00pt5	683	31	animal	animal	NN
cord-016293-pyb00pt5	683	32	research	research	NN
cord-016293-pyb00pt5	683	33	.	.	.
cord-016293-pyb00pt5	684	1	As	as	IN
cord-016293-pyb00pt5	684	2	the	the	DT
cord-016293-pyb00pt5	684	3	decade	decade	NN
cord-016293-pyb00pt5	684	4	reached	reach	VBD
cord-016293-pyb00pt5	684	5	its	-PRON-	PRP$
cord-016293-pyb00pt5	684	6	end	end	NN
cord-016293-pyb00pt5	684	7	the	the	DT
cord-016293-pyb00pt5	684	8	clones	clone	NNS
cord-016293-pyb00pt5	684	9	began	begin	VBD
cord-016293-pyb00pt5	684	10	arriving	arrive	VBG
cord-016293-pyb00pt5	684	11	rapidly	rapidly	RB
cord-016293-pyb00pt5	684	12	with	with	IN
cord-016293-pyb00pt5	684	13	specific	specific	JJ
cord-016293-pyb00pt5	684	14	advances	advance	NNS
cord-016293-pyb00pt5	684	15	made	make	VBN
cord-016293-pyb00pt5	684	16	by	by	IN
cord-016293-pyb00pt5	684	17	a	a	DT
cord-016293-pyb00pt5	684	18	Japanese	japanese	JJ
cord-016293-pyb00pt5	684	19	group	group	NN
cord-016293-pyb00pt5	684	20	who	who	WP
cord-016293-pyb00pt5	684	21	used	use	VBD
cord-016293-pyb00pt5	684	22	cumulus	cumulus	NN
cord-016293-pyb00pt5	684	23	cells	cell	NNS
cord-016293-pyb00pt5	684	24	rather	rather	RB
cord-016293-pyb00pt5	684	25	than	than	IN
cord-016293-pyb00pt5	684	26	fibroblasts	fibroblast	NNS
cord-016293-pyb00pt5	684	27	to	to	TO
cord-016293-pyb00pt5	684	28	clone	clone	VB
cord-016293-pyb00pt5	684	29	calves	calf	NNS
cord-016293-pyb00pt5	684	30	.	.	.
cord-016293-pyb00pt5	685	1	They	-PRON-	PRP
cord-016293-pyb00pt5	685	2	found	find	VBD
cord-016293-pyb00pt5	685	3	that	that	IN
cord-016293-pyb00pt5	685	4	the	the	DT
cord-016293-pyb00pt5	685	5	percentage	percentage	NN
cord-016293-pyb00pt5	685	6	of	of	IN
cord-016293-pyb00pt5	685	7	cultured	cultured	JJ
cord-016293-pyb00pt5	685	8	,	,	,
cord-016293-pyb00pt5	685	9	reconstructed	reconstruct	VBN
cord-016293-pyb00pt5	685	10	eggs	egg	NNS
cord-016293-pyb00pt5	685	11	that	that	WDT
cord-016293-pyb00pt5	685	12	developed	develop	VBD
cord-016293-pyb00pt5	685	13	into	into	IN
cord-016293-pyb00pt5	685	14	blastocysts	blastocyst	NNS
cord-016293-pyb00pt5	685	15	was	be	VBD
cord-016293-pyb00pt5	685	16	49	49	CD
cord-016293-pyb00pt5	685	17	%	%	NN
cord-016293-pyb00pt5	685	18	for	for	IN
cord-016293-pyb00pt5	685	19	cumulus	cumulus	NN
cord-016293-pyb00pt5	685	20	cells	cell	NNS
cord-016293-pyb00pt5	685	21	and	and	CC
cord-016293-pyb00pt5	685	22	23	23	CD
cord-016293-pyb00pt5	685	23	%	%	NN
cord-016293-pyb00pt5	685	24	for	for	IN
cord-016293-pyb00pt5	685	25	oviductal	oviductal	JJ
cord-016293-pyb00pt5	685	26	cells	cell	NNS
cord-016293-pyb00pt5	685	27	.	.	.
cord-016293-pyb00pt5	686	1	These	these	DT
cord-016293-pyb00pt5	686	2	rates	rate	NNS
cord-016293-pyb00pt5	686	3	are	be	VBP
cord-016293-pyb00pt5	686	4	higher	high	JJR
cord-016293-pyb00pt5	686	5	than	than	IN
cord-016293-pyb00pt5	686	6	the	the	DT
cord-016293-pyb00pt5	686	7	12	12	CD
cord-016293-pyb00pt5	686	8	%	%	NN
cord-016293-pyb00pt5	686	9	previously	previously	RB
cord-016293-pyb00pt5	686	10	reported	report	VBN
cord-016293-pyb00pt5	686	11	for	for	IN
cord-016293-pyb00pt5	686	12	transfer	transfer	NN
cord-016293-pyb00pt5	686	13	of	of	IN
cord-016293-pyb00pt5	686	14	nuclei	nucleus	NNS
cord-016293-pyb00pt5	686	15	from	from	IN
cord-016293-pyb00pt5	686	16	bovine	bovine	JJ
cord-016293-pyb00pt5	686	17	fetal	fetal	JJ
cord-016293-pyb00pt5	686	18	fibroblasts	fibroblast	NNS
cord-016293-pyb00pt5	686	19	.	.	.
cord-016293-pyb00pt5	687	1	Following	follow	VBG
cord-016293-pyb00pt5	687	2	on	on	IN
cord-016293-pyb00pt5	687	3	the	the	DT
cord-016293-pyb00pt5	687	4	heels	heel	NNS
cord-016293-pyb00pt5	687	5	of	of	IN
cord-016293-pyb00pt5	687	6	Dolly	Dolly	NNP
cord-016293-pyb00pt5	687	7	,	,	,
cord-016293-pyb00pt5	687	8	Polly	Polly	NNP
cord-016293-pyb00pt5	687	9	and	and	CC
cord-016293-pyb00pt5	687	10	Molly	Molly	NNP
cord-016293-pyb00pt5	687	11	became	become	VBD
cord-016293-pyb00pt5	687	12	the	the	DT
cord-016293-pyb00pt5	687	13	first	first	JJ
cord-016293-pyb00pt5	687	14	genetically	genetically	RB
cord-016293-pyb00pt5	687	15	engineered	engineer	VBN
cord-016293-pyb00pt5	687	16	transgenic	transgenic	JJ
cord-016293-pyb00pt5	687	17	sheep	sheep	NNS
cord-016293-pyb00pt5	687	18	produced	produce	VBN
cord-016293-pyb00pt5	687	19	through	through	IN
cord-016293-pyb00pt5	687	20	nuclear	nuclear	JJ
cord-016293-pyb00pt5	687	21	transfer	transfer	NN
cord-016293-pyb00pt5	687	22	technology	technology	NN
cord-016293-pyb00pt5	687	23	.	.	.
cord-016293-pyb00pt5	688	1	Polly	Polly	NNP
cord-016293-pyb00pt5	688	2	and	and	CC
cord-016293-pyb00pt5	688	3	Molly	Molly	NNP
cord-016293-pyb00pt5	688	4	were	be	VBD
cord-016293-pyb00pt5	688	5	engineered	engineer	VBN
cord-016293-pyb00pt5	688	6	to	to	TO
cord-016293-pyb00pt5	688	7	produce	produce	VB
cord-016293-pyb00pt5	688	8	human	human	JJ
cord-016293-pyb00pt5	688	9	factor	factor	NN
cord-016293-pyb00pt5	688	10	IX	IX	NNP
cord-016293-pyb00pt5	688	11	(	(	-LRB-
cord-016293-pyb00pt5	688	12	for	for	IN
cord-016293-pyb00pt5	688	13	hemophiliacs	hemophiliac	NNS
cord-016293-pyb00pt5	688	14	)	)	-RRB-
cord-016293-pyb00pt5	688	15	by	by	IN
cord-016293-pyb00pt5	688	16	transfer	transfer	NN
cord-016293-pyb00pt5	688	17	of	of	IN
cord-016293-pyb00pt5	688	18	nuclei	nucleus	NNS
cord-016293-pyb00pt5	688	19	from	from	IN
cord-016293-pyb00pt5	688	20	transfected	transfecte	VBN
cord-016293-pyb00pt5	688	21	fetal	fetal	JJ
cord-016293-pyb00pt5	688	22	fibroblasts	fibroblast	NNS
cord-016293-pyb00pt5	688	23	.	.	.
cord-016293-pyb00pt5	689	1	Until	until	IN
cord-016293-pyb00pt5	689	2	then	then	RB
cord-016293-pyb00pt5	689	3	germline	germline	JJ
cord-016293-pyb00pt5	689	4	competent	competent	JJ
cord-016293-pyb00pt5	689	5	transgenics	transgenic	NNS
cord-016293-pyb00pt5	689	6	had	have	VBD
cord-016293-pyb00pt5	689	7	only	only	RB
cord-016293-pyb00pt5	689	8	been	be	VBN
cord-016293-pyb00pt5	689	9	produced	produce	VBN
cord-016293-pyb00pt5	689	10	in	in	IN
cord-016293-pyb00pt5	689	11	mammalian	mammalian	JJ
cord-016293-pyb00pt5	689	12	species	specie	NNS
cord-016293-pyb00pt5	689	13	,	,	,
cord-016293-pyb00pt5	689	14	other	other	JJ
cord-016293-pyb00pt5	689	15	than	than	IN
cord-016293-pyb00pt5	689	16	mice	mouse	NNS
cord-016293-pyb00pt5	689	17	,	,	,
cord-016293-pyb00pt5	689	18	using	use	VBG
cord-016293-pyb00pt5	689	19	DNA	dna	NN
cord-016293-pyb00pt5	689	20	microinjection	microinjection	NN
cord-016293-pyb00pt5	689	21	.	.	.
cord-016293-pyb00pt5	690	1	Researchers	researcher	NNS
cord-016293-pyb00pt5	690	2	at	at	IN
cord-016293-pyb00pt5	690	3	the	the	DT
cord-016293-pyb00pt5	690	4	University	University	NNP
cord-016293-pyb00pt5	690	5	of	of	IN
cord-016293-pyb00pt5	690	6	Massachusetts	Massachusetts	NNP
cord-016293-pyb00pt5	690	7	and	and	CC
cord-016293-pyb00pt5	690	8	Advanced	Advanced	NNP
cord-016293-pyb00pt5	690	9	Cell	Cell	NNP
cord-016293-pyb00pt5	690	10	Technology	Technology	NNP
cord-016293-pyb00pt5	690	11	(	(	-LRB-
cord-016293-pyb00pt5	690	12	Worcester	Worcester	NNP
cord-016293-pyb00pt5	690	13	,	,	,
cord-016293-pyb00pt5	690	14	MA	MA	NNP
cord-016293-pyb00pt5	690	15	)	)	-RRB-
cord-016293-pyb00pt5	690	16	teamed	team	VBD
cord-016293-pyb00pt5	690	17	up	up	RP
cord-016293-pyb00pt5	690	18	to	to	TO
cord-016293-pyb00pt5	690	19	produce	produce	VB
cord-016293-pyb00pt5	690	20	genetically	genetically	RB
cord-016293-pyb00pt5	690	21	identical	identical	JJ
cord-016293-pyb00pt5	690	22	calves	calf	NNS
cord-016293-pyb00pt5	690	23	utilizing	utilize	VBG
cord-016293-pyb00pt5	690	24	a	a	DT
cord-016293-pyb00pt5	690	25	strategy	strategy	NN
cord-016293-pyb00pt5	690	26	similar	similar	JJ
cord-016293-pyb00pt5	690	27	to	to	IN
cord-016293-pyb00pt5	690	28	that	that	DT
cord-016293-pyb00pt5	690	29	used	use	VBN
cord-016293-pyb00pt5	690	30	to	to	TO
cord-016293-pyb00pt5	690	31	produce	produce	VB
cord-016293-pyb00pt5	690	32	transgenic	transgenic	JJ
cord-016293-pyb00pt5	690	33	sheep	sheep	NNS
cord-016293-pyb00pt5	690	34	.	.	.
cord-016293-pyb00pt5	691	1	In	in	IN
cord-016293-pyb00pt5	691	2	contrast	contrast	NN
cord-016293-pyb00pt5	691	3	to	to	IN
cord-016293-pyb00pt5	691	4	the	the	DT
cord-016293-pyb00pt5	691	5	sheep	sheep	NN
cord-016293-pyb00pt5	691	6	cloning	clone	VBG
cord-016293-pyb00pt5	691	7	experiment	experiment	NN
cord-016293-pyb00pt5	691	8	,	,	,
cord-016293-pyb00pt5	691	9	the	the	DT
cord-016293-pyb00pt5	691	10	bovine	bovine	JJ
cord-016293-pyb00pt5	691	11	experiment	experiment	NN
cord-016293-pyb00pt5	691	12	involved	involve	VBD
cord-016293-pyb00pt5	691	13	the	the	DT
cord-016293-pyb00pt5	691	14	transfer	transfer	NN
cord-016293-pyb00pt5	691	15	of	of	IN
cord-016293-pyb00pt5	691	16	nuclei	nucleus	NNS
cord-016293-pyb00pt5	691	17	from	from	IN
cord-016293-pyb00pt5	691	18	an	an	DT
cord-016293-pyb00pt5	691	19	actively	actively	RB
cord-016293-pyb00pt5	691	20	dividing	divide	VBG
cord-016293-pyb00pt5	691	21	population	population	NN
cord-016293-pyb00pt5	691	22	of	of	IN
cord-016293-pyb00pt5	691	23	cells	cell	NNS
cord-016293-pyb00pt5	691	24	.	.	.
cord-016293-pyb00pt5	692	1	Previous	previous	JJ
cord-016293-pyb00pt5	692	2	results	result	NNS
cord-016293-pyb00pt5	692	3	from	from	IN
cord-016293-pyb00pt5	692	4	the	the	DT
cord-016293-pyb00pt5	692	5	sheep	sheep	NN
cord-016293-pyb00pt5	692	6	experiments	experiment	NNS
cord-016293-pyb00pt5	692	7	suggested	suggest	VBD
cord-016293-pyb00pt5	692	8	that	that	IN
cord-016293-pyb00pt5	692	9	induction	induction	NN
cord-016293-pyb00pt5	692	10	of	of	IN
cord-016293-pyb00pt5	692	11	quiescence	quiescence	NN
cord-016293-pyb00pt5	692	12	by	by	IN
cord-016293-pyb00pt5	692	13	serum	serum	NN
cord-016293-pyb00pt5	692	14	starvation	starvation	NN
cord-016293-pyb00pt5	692	15	was	be	VBD
cord-016293-pyb00pt5	692	16	required	require	VBN
cord-016293-pyb00pt5	692	17	to	to	TO
cord-016293-pyb00pt5	692	18	reprogram	reprogram	VB
cord-016293-pyb00pt5	692	19	the	the	DT
cord-016293-pyb00pt5	692	20	donor	donor	NN
cord-016293-pyb00pt5	692	21	nuclei	nucleus	NNS
cord-016293-pyb00pt5	692	22	for	for	IN
cord-016293-pyb00pt5	692	23	successful	successful	JJ
cord-016293-pyb00pt5	692	24	nuclear	nuclear	JJ
cord-016293-pyb00pt5	692	25	transfer	transfer	NN
cord-016293-pyb00pt5	692	26	.	.	.
cord-016293-pyb00pt5	693	1	The	the	DT
cord-016293-pyb00pt5	693	2	current	current	JJ
cord-016293-pyb00pt5	693	3	bovine	bovine	JJ
cord-016293-pyb00pt5	693	4	experiments	experiment	NNS
cord-016293-pyb00pt5	693	5	indicate	indicate	VBP
cord-016293-pyb00pt5	693	6	that	that	IN
cord-016293-pyb00pt5	693	7	this	this	DT
cord-016293-pyb00pt5	693	8	step	step	NN
cord-016293-pyb00pt5	693	9	may	may	MD
cord-016293-pyb00pt5	693	10	not	not	RB
cord-016293-pyb00pt5	693	11	be	be	VB
cord-016293-pyb00pt5	693	12	necessary	necessary	JJ
cord-016293-pyb00pt5	693	13	.	.	.
cord-016293-pyb00pt5	694	1	Typically	typically	RB
cord-016293-pyb00pt5	694	2	about	about	IN
cord-016293-pyb00pt5	694	3	500	500	CD
cord-016293-pyb00pt5	694	4	embryos	embryo	NNS
cord-016293-pyb00pt5	694	5	needed	need	VBN
cord-016293-pyb00pt5	694	6	to	to	TO
cord-016293-pyb00pt5	694	7	be	be	VB
cord-016293-pyb00pt5	694	8	microinjected	microinjecte	VBN
cord-016293-pyb00pt5	694	9	to	to	TO
cord-016293-pyb00pt5	694	10	obtain	obtain	VB
cord-016293-pyb00pt5	694	11	one	one	CD
cord-016293-pyb00pt5	694	12	transgenic	transgenic	JJ
cord-016293-pyb00pt5	694	13	cow	cow	NN
cord-016293-pyb00pt5	694	14	,	,	,
cord-016293-pyb00pt5	694	15	whereas	whereas	IN
cord-016293-pyb00pt5	694	16	nuclear	nuclear	JJ
cord-016293-pyb00pt5	694	17	transfer	transfer	NN
cord-016293-pyb00pt5	694	18	produced	produce	VBD
cord-016293-pyb00pt5	694	19	three	three	CD
cord-016293-pyb00pt5	694	20	transgenic	transgenic	JJ
cord-016293-pyb00pt5	694	21	calves	calf	NNS
cord-016293-pyb00pt5	694	22	from	from	IN
cord-016293-pyb00pt5	694	23	276	276	CD
cord-016293-pyb00pt5	694	24	reconstructed	reconstruct	VBN
cord-016293-pyb00pt5	694	25	embryos	embryo	NNS
cord-016293-pyb00pt5	694	26	.	.	.
cord-016293-pyb00pt5	695	1	This	this	DT
cord-016293-pyb00pt5	695	2	efficiency	efficiency	NN
cord-016293-pyb00pt5	695	3	is	be	VBZ
cord-016293-pyb00pt5	695	4	comparable	comparable	JJ
cord-016293-pyb00pt5	695	5	to	to	IN
cord-016293-pyb00pt5	695	6	the	the	DT
cord-016293-pyb00pt5	695	7	previous	previous	JJ
cord-016293-pyb00pt5	695	8	sheep	sheep	NN
cord-016293-pyb00pt5	695	9	research	research	NN
cord-016293-pyb00pt5	695	10	where	where	WRB
cord-016293-pyb00pt5	695	11	six	six	CD
cord-016293-pyb00pt5	695	12	transgenic	transgenic	JJ
cord-016293-pyb00pt5	695	13	lambs	lamb	NNS
cord-016293-pyb00pt5	695	14	were	be	VBD
cord-016293-pyb00pt5	695	15	produced	produce	VBN
cord-016293-pyb00pt5	695	16	from	from	IN
cord-016293-pyb00pt5	695	17	425	425	CD
cord-016293-pyb00pt5	695	18	reconstructed	reconstruct	VBN
cord-016293-pyb00pt5	695	19	embryos	embryo	NNS
cord-016293-pyb00pt5	695	20	.	.	.
cord-016293-pyb00pt5	696	1	The	the	DT
cord-016293-pyb00pt5	696	2	ability	ability	NN
cord-016293-pyb00pt5	696	3	to	to	TO
cord-016293-pyb00pt5	696	4	select	select	VB
cord-016293-pyb00pt5	696	5	for	for	IN
cord-016293-pyb00pt5	696	6	genetically	genetically	RB
cord-016293-pyb00pt5	696	7	modified	modify	VBN
cord-016293-pyb00pt5	696	8	cells	cell	NNS
cord-016293-pyb00pt5	696	9	in	in	IN
cord-016293-pyb00pt5	696	10	culture	culture	NN
cord-016293-pyb00pt5	696	11	prior	prior	RB
cord-016293-pyb00pt5	696	12	to	to	IN
cord-016293-pyb00pt5	696	13	nuclear	nuclear	JJ
cord-016293-pyb00pt5	696	14	transfer	transfer	NN
cord-016293-pyb00pt5	696	15	opens	open	VBZ
cord-016293-pyb00pt5	696	16	up	up	RP
cord-016293-pyb00pt5	696	17	the	the	DT
cord-016293-pyb00pt5	696	18	possibility	possibility	NN
cord-016293-pyb00pt5	696	19	of	of	IN
cord-016293-pyb00pt5	696	20	applying	apply	VBG
cord-016293-pyb00pt5	696	21	the	the	DT
cord-016293-pyb00pt5	696	22	powerful	powerful	JJ
cord-016293-pyb00pt5	696	23	gene	gene	NN
cord-016293-pyb00pt5	696	24	targeting	target	VBG
cord-016293-pyb00pt5	696	25	techniques	technique	NNS
cord-016293-pyb00pt5	696	26	that	that	WDT
cord-016293-pyb00pt5	696	27	have	have	VBP
cord-016293-pyb00pt5	696	28	been	be	VBN
cord-016293-pyb00pt5	696	29	developed	develop	VBN
cord-016293-pyb00pt5	696	30	for	for	IN
cord-016293-pyb00pt5	696	31	mice	mouse	NNS
cord-016293-pyb00pt5	696	32	.	.	.
cord-016293-pyb00pt5	697	1	One	one	CD
cord-016293-pyb00pt5	697	2	of	of	IN
cord-016293-pyb00pt5	697	3	the	the	DT
cord-016293-pyb00pt5	697	4	limitations	limitation	NNS
cord-016293-pyb00pt5	697	5	of	of	IN
cord-016293-pyb00pt5	697	6	using	use	VBG
cord-016293-pyb00pt5	697	7	primary	primary	JJ
cord-016293-pyb00pt5	697	8	cells	cell	NNS
cord-016293-pyb00pt5	697	9	,	,	,
cord-016293-pyb00pt5	697	10	however	however	RB
cord-016293-pyb00pt5	697	11	,	,	,
cord-016293-pyb00pt5	697	12	is	be	VBZ
cord-016293-pyb00pt5	697	13	their	-PRON-	PRP$
cord-016293-pyb00pt5	697	14	limited	limited	JJ
cord-016293-pyb00pt5	697	15	lifespan	lifespan	NN
cord-016293-pyb00pt5	697	16	in	in	IN
cord-016293-pyb00pt5	697	17	culture	culture	NN
cord-016293-pyb00pt5	697	18	.	.	.
cord-016293-pyb00pt5	698	1	Primary	primary	JJ
cord-016293-pyb00pt5	698	2	cell	cell	NN
cord-016293-pyb00pt5	698	3	cultures	culture	NNS
cord-016293-pyb00pt5	698	4	such	such	JJ
cord-016293-pyb00pt5	698	5	as	as	IN
cord-016293-pyb00pt5	698	6	the	the	DT
cord-016293-pyb00pt5	698	7	fetal	fetal	JJ
cord-016293-pyb00pt5	698	8	fibroblasts	fibroblast	NNS
cord-016293-pyb00pt5	698	9	can	can	MD
cord-016293-pyb00pt5	698	10	only	only	RB
cord-016293-pyb00pt5	698	11	undergo	undergo	VB
cord-016293-pyb00pt5	698	12	about	about	RB
cord-016293-pyb00pt5	698	13	30	30	CD
cord-016293-pyb00pt5	698	14	population	population	NN
cord-016293-pyb00pt5	698	15	doublings	doubling	NNS
cord-016293-pyb00pt5	698	16	before	before	IN
cord-016293-pyb00pt5	698	17	they	-PRON-	PRP
cord-016293-pyb00pt5	698	18	senesce	senesce	VBP
cord-016293-pyb00pt5	698	19	.	.	.
cord-016293-pyb00pt5	699	1	This	this	DT
cord-016293-pyb00pt5	699	2	limited	limited	JJ
cord-016293-pyb00pt5	699	3	lifespan	lifespan	NN
cord-016293-pyb00pt5	699	4	would	would	MD
cord-016293-pyb00pt5	699	5	preclude	preclude	VB
cord-016293-pyb00pt5	699	6	the	the	DT
cord-016293-pyb00pt5	699	7	ability	ability	NN
cord-016293-pyb00pt5	699	8	to	to	TO
cord-016293-pyb00pt5	699	9	perform	perform	VB
cord-016293-pyb00pt5	699	10	multiple	multiple	JJ
cord-016293-pyb00pt5	699	11	rounds	round	NNS
cord-016293-pyb00pt5	699	12	of	of	IN
cord-016293-pyb00pt5	699	13	selection	selection	NN
cord-016293-pyb00pt5	699	14	.	.	.
cord-016293-pyb00pt5	700	1	To	to	TO
cord-016293-pyb00pt5	700	2	overcome	overcome	VB
cord-016293-pyb00pt5	700	3	this	this	DT
cord-016293-pyb00pt5	700	4	problem	problem	NN
cord-016293-pyb00pt5	700	5	of	of	IN
cord-016293-pyb00pt5	700	6	cell	cell	NN
cord-016293-pyb00pt5	700	7	senescence	senescence	NN
cord-016293-pyb00pt5	700	8	,	,	,
cord-016293-pyb00pt5	700	9	these	these	DT
cord-016293-pyb00pt5	700	10	researchers	researcher	NNS
cord-016293-pyb00pt5	700	11	showed	show	VBD
cord-016293-pyb00pt5	700	12	that	that	IN
cord-016293-pyb00pt5	700	13	fibroblast	fibroblast	NN
cord-016293-pyb00pt5	700	14	lifespan	lifespan	NN
cord-016293-pyb00pt5	700	15	could	could	MD
cord-016293-pyb00pt5	700	16	be	be	VB
cord-016293-pyb00pt5	700	17	prolonged	prolong	VBN
cord-016293-pyb00pt5	700	18	by	by	IN
cord-016293-pyb00pt5	700	19	nuclear	nuclear	JJ
cord-016293-pyb00pt5	700	20	transfer	transfer	NN
cord-016293-pyb00pt5	700	21	.	.	.
cord-016293-pyb00pt5	701	1	A	a	DT
cord-016293-pyb00pt5	701	2	fetus	fetus	NN
cord-016293-pyb00pt5	701	3	,	,	,
cord-016293-pyb00pt5	701	4	which	which	WDT
cord-016293-pyb00pt5	701	5	was	be	VBD
cord-016293-pyb00pt5	701	6	developed	develop	VBN
cord-016293-pyb00pt5	701	7	by	by	IN
cord-016293-pyb00pt5	701	8	nuclear	nuclear	JJ
cord-016293-pyb00pt5	701	9	transfer	transfer	NN
cord-016293-pyb00pt5	701	10	from	from	IN
cord-016293-pyb00pt5	701	11	genetically	genetically	RB
cord-016293-pyb00pt5	701	12	modified	modify	VBN
cord-016293-pyb00pt5	701	13	cells	cell	NNS
cord-016293-pyb00pt5	701	14	,	,	,
cord-016293-pyb00pt5	701	15	could	could	MD
cord-016293-pyb00pt5	701	16	in	in	IN
cord-016293-pyb00pt5	701	17	turn	turn	NN
cord-016293-pyb00pt5	701	18	be	be	VB
cord-016293-pyb00pt5	701	19	used	use	VBN
cord-016293-pyb00pt5	701	20	to	to	TO
cord-016293-pyb00pt5	701	21	establish	establish	VB
cord-016293-pyb00pt5	701	22	a	a	DT
cord-016293-pyb00pt5	701	23	second	second	JJ
cord-016293-pyb00pt5	701	24	generation	generation	NN
cord-016293-pyb00pt5	701	25	of	of	IN
cord-016293-pyb00pt5	701	26	fetal	fetal	JJ
cord-016293-pyb00pt5	701	27	fibroblasts	fibroblast	NNS
cord-016293-pyb00pt5	701	28	.	.	.
cord-016293-pyb00pt5	702	1	These	these	DT
cord-016293-pyb00pt5	702	2	fetal	fetal	JJ
cord-016293-pyb00pt5	702	3	cells	cell	NNS
cord-016293-pyb00pt5	702	4	would	would	MD
cord-016293-pyb00pt5	702	5	then	then	RB
cord-016293-pyb00pt5	702	6	be	be	VB
cord-016293-pyb00pt5	702	7	capable	capable	JJ
cord-016293-pyb00pt5	702	8	of	of	IN
cord-016293-pyb00pt5	702	9	undergoing	undergo	VBG
cord-016293-pyb00pt5	702	10	another	another	DT
cord-016293-pyb00pt5	702	11	30	30	CD
cord-016293-pyb00pt5	702	12	population	population	NN
cord-016293-pyb00pt5	702	13	doublings	doubling	NNS
cord-016293-pyb00pt5	702	14	,	,	,
cord-016293-pyb00pt5	702	15	which	which	WDT
cord-016293-pyb00pt5	702	16	would	would	MD
cord-016293-pyb00pt5	702	17	provide	provide	VB
cord-016293-pyb00pt5	702	18	sufficient	sufficient	JJ
cord-016293-pyb00pt5	702	19	time	time	NN
cord-016293-pyb00pt5	702	20	for	for	IN
cord-016293-pyb00pt5	702	21	selection	selection	NN
cord-016293-pyb00pt5	702	22	of	of	IN
cord-016293-pyb00pt5	702	23	a	a	DT
cord-016293-pyb00pt5	702	24	second	second	JJ
cord-016293-pyb00pt5	702	25	genetic	genetic	JJ
cord-016293-pyb00pt5	702	26	modification	modification	NN
cord-016293-pyb00pt5	702	27	.	.	.
cord-016293-pyb00pt5	703	1	As	as	IN
cord-016293-pyb00pt5	703	2	noted	note	VBN
cord-016293-pyb00pt5	703	3	,	,	,
cord-016293-pyb00pt5	703	4	there	there	EX
cord-016293-pyb00pt5	703	5	is	be	VBZ
cord-016293-pyb00pt5	703	6	still	still	RB
cord-016293-pyb00pt5	703	7	some	some	DT
cord-016293-pyb00pt5	703	8	uncertainty	uncertainty	NN
cord-016293-pyb00pt5	703	9	over	over	IN
cord-016293-pyb00pt5	703	10	whether	whether	IN
cord-016293-pyb00pt5	703	11	quiescent	quiescent	JJ
cord-016293-pyb00pt5	703	12	cells	cell	NNS
cord-016293-pyb00pt5	703	13	are	be	VBP
cord-016293-pyb00pt5	703	14	required	require	VBN
cord-016293-pyb00pt5	703	15	for	for	IN
cord-016293-pyb00pt5	703	16	successful	successful	JJ
cord-016293-pyb00pt5	703	17	nuclear	nuclear	JJ
cord-016293-pyb00pt5	703	18	transfer	transfer	NN
cord-016293-pyb00pt5	703	19	.	.	.
cord-016293-pyb00pt5	704	1	Induction	induction	NN
cord-016293-pyb00pt5	704	2	into	into	IN
cord-016293-pyb00pt5	704	3	quiescence	quiescence	NN
cord-016293-pyb00pt5	704	4	was	be	VBD
cord-016293-pyb00pt5	704	5	originally	originally	RB
cord-016293-pyb00pt5	704	6	thought	think	VBN
cord-016293-pyb00pt5	704	7	to	to	TO
cord-016293-pyb00pt5	704	8	be	be	VB
cord-016293-pyb00pt5	704	9	necessary	necessary	JJ
cord-016293-pyb00pt5	704	10	for	for	IN
cord-016293-pyb00pt5	704	11	successful	successful	JJ
cord-016293-pyb00pt5	704	12	nuclear	nuclear	JJ
cord-016293-pyb00pt5	704	13	reprogramming	reprogramming	NN
cord-016293-pyb00pt5	704	14	of	of	IN
cord-016293-pyb00pt5	704	15	the	the	DT
cord-016293-pyb00pt5	704	16	donor	donor	NN
cord-016293-pyb00pt5	704	17	nucleus	nucleus	NN
cord-016293-pyb00pt5	704	18	.	.	.
cord-016293-pyb00pt5	705	1	However	however	RB
cord-016293-pyb00pt5	705	2	,	,	,
cord-016293-pyb00pt5	705	3	cloned	clone	VBN
cord-016293-pyb00pt5	705	4	calves	calf	NNS
cord-016293-pyb00pt5	705	5	have	have	VBP
cord-016293-pyb00pt5	705	6	been	be	VBN
cord-016293-pyb00pt5	705	7	previously	previously	RB
cord-016293-pyb00pt5	705	8	produced	produce	VBN
cord-016293-pyb00pt5	705	9	using	use	VBG
cord-016293-pyb00pt5	705	10	non	non	JJ
cord-016293-pyb00pt5	705	11	-	-	JJ
cord-016293-pyb00pt5	705	12	quiescent	quiescent	JJ
cord-016293-pyb00pt5	705	13	fetal	fetal	JJ
cord-016293-pyb00pt5	705	14	cells	cell	NNS
cord-016293-pyb00pt5	705	15	.	.	.
cord-016293-pyb00pt5	706	1	Furthermore	furthermore	RB
cord-016293-pyb00pt5	706	2	,	,	,
cord-016293-pyb00pt5	706	3	transfer	transfer	NN
cord-016293-pyb00pt5	706	4	of	of	IN
cord-016293-pyb00pt5	706	5	nuclei	nucleus	NNS
cord-016293-pyb00pt5	706	6	from	from	IN
cord-016293-pyb00pt5	706	7	Sertoli	Sertoli	NNP
cord-016293-pyb00pt5	706	8	and	and	CC
cord-016293-pyb00pt5	706	9	neuronal	neuronal	JJ
cord-016293-pyb00pt5	706	10	cells	cell	NNS
cord-016293-pyb00pt5	706	11	,	,	,
cord-016293-pyb00pt5	706	12	which	which	WDT
cord-016293-pyb00pt5	706	13	do	do	VBP
cord-016293-pyb00pt5	706	14	not	not	RB
cord-016293-pyb00pt5	706	15	normally	normally	RB
cord-016293-pyb00pt5	706	16	divide	divide	VB
cord-016293-pyb00pt5	706	17	in	in	IN
cord-016293-pyb00pt5	706	18	adults	adult	NNS
cord-016293-pyb00pt5	706	19	,	,	,
cord-016293-pyb00pt5	706	20	did	do	VBD
cord-016293-pyb00pt5	706	21	not	not	RB
cord-016293-pyb00pt5	706	22	produce	produce	VB
cord-016293-pyb00pt5	706	23	a	a	DT
cord-016293-pyb00pt5	706	24	liveborn	liveborn	NN
cord-016293-pyb00pt5	706	25	mouse	mouse	NN
cord-016293-pyb00pt5	706	26	;	;	:
cord-016293-pyb00pt5	706	27	whereas	whereas	IN
cord-016293-pyb00pt5	706	28	nuclei	nucleus	NNS
cord-016293-pyb00pt5	706	29	transferred	transfer	VBN
cord-016293-pyb00pt5	706	30	from	from	IN
cord-016293-pyb00pt5	706	31	actively	actively	RB
cord-016293-pyb00pt5	706	32	dividing	divide	VBG
cord-016293-pyb00pt5	706	33	cumulus	cumulus	NN
cord-016293-pyb00pt5	706	34	cells	cell	NNS
cord-016293-pyb00pt5	706	35	did	do	VBD
cord-016293-pyb00pt5	706	36	produce	produce	VB
cord-016293-pyb00pt5	706	37	cloned	clone	VBN
cord-016293-pyb00pt5	706	38	mice	mouse	NNS
cord-016293-pyb00pt5	706	39	.	.	.
cord-016293-pyb00pt5	707	1	The	the	DT
cord-016293-pyb00pt5	707	2	fetuses	fetus	NNS
cord-016293-pyb00pt5	707	3	used	use	VBN
cord-016293-pyb00pt5	707	4	for	for	IN
cord-016293-pyb00pt5	707	5	establishing	establish	VBG
cord-016293-pyb00pt5	707	6	fetal	fetal	JJ
cord-016293-pyb00pt5	707	7	cell	cell	NN
cord-016293-pyb00pt5	707	8	lines	line	NNS
cord-016293-pyb00pt5	707	9	in	in	IN
cord-016293-pyb00pt5	707	10	a	a	DT
cord-016293-pyb00pt5	707	11	Tufts	Tufts	NNP
cord-016293-pyb00pt5	707	12	goat	goat	NN
cord-016293-pyb00pt5	707	13	study	study	NN
cord-016293-pyb00pt5	707	14	were	be	VBD
cord-016293-pyb00pt5	707	15	generated	generate	VBN
cord-016293-pyb00pt5	707	16	by	by	IN
cord-016293-pyb00pt5	707	17	mating	mate	VBG
cord-016293-pyb00pt5	707	18	nontransgenic	nontransgenic	NNP
cord-016293-pyb00pt5	707	19	females	female	NNS
cord-016293-pyb00pt5	707	20	to	to	IN
cord-016293-pyb00pt5	707	21	a	a	DT
cord-016293-pyb00pt5	707	22	transgenic	transgenic	JJ
cord-016293-pyb00pt5	707	23	male	male	NN
cord-016293-pyb00pt5	707	24	containing	contain	VBG
cord-016293-pyb00pt5	707	25	a	a	DT
cord-016293-pyb00pt5	707	26	human	human	JJ
cord-016293-pyb00pt5	707	27	antithrombin	antithrombin	NN
cord-016293-pyb00pt5	707	28	(	(	-LRB-
cord-016293-pyb00pt5	707	29	AT	AT	NNP
cord-016293-pyb00pt5	707	30	)	)	-RRB-
cord-016293-pyb00pt5	707	31	III	iii	CD
cord-016293-pyb00pt5	707	32	transgene	transgene	NN
cord-016293-pyb00pt5	707	33	.	.	.
cord-016293-pyb00pt5	708	1	This	this	DT
cord-016293-pyb00pt5	708	2	AT	AT	NNP
cord-016293-pyb00pt5	708	3	transgene	transgene	NN
cord-016293-pyb00pt5	708	4	directs	direct	VBZ
cord-016293-pyb00pt5	708	5	high	high	JJ
cord-016293-pyb00pt5	708	6	level	level	NN
cord-016293-pyb00pt5	708	7	expression	expression	NN
cord-016293-pyb00pt5	708	8	of	of	IN
cord-016293-pyb00pt5	708	9	human	human	NN
cord-016293-pyb00pt5	708	10	AT	at	IN
cord-016293-pyb00pt5	708	11	into	into	IN
cord-016293-pyb00pt5	708	12	milk	milk	NN
cord-016293-pyb00pt5	708	13	of	of	IN
cord-016293-pyb00pt5	708	14	lactating	lactate	VBG
cord-016293-pyb00pt5	708	15	transgenic	transgenic	JJ
cord-016293-pyb00pt5	708	16	females	female	NNS
cord-016293-pyb00pt5	708	17	.	.	.
cord-016293-pyb00pt5	709	1	As	as	IN
cord-016293-pyb00pt5	709	2	expected	expect	VBN
cord-016293-pyb00pt5	709	3	,	,	,
cord-016293-pyb00pt5	709	4	all	all	DT
cord-016293-pyb00pt5	709	5	three	three	CD
cord-016293-pyb00pt5	709	6	offspring	offspring	NN
cord-016293-pyb00pt5	709	7	derived	derive	VBN
cord-016293-pyb00pt5	709	8	from	from	IN
cord-016293-pyb00pt5	709	9	female	female	JJ
cord-016293-pyb00pt5	709	10	fetal	fetal	JJ
cord-016293-pyb00pt5	709	11	cells	cell	NNS
cord-016293-pyb00pt5	709	12	were	be	VBD
cord-016293-pyb00pt5	709	13	females	female	NNS
cord-016293-pyb00pt5	709	14	.	.	.
cord-016293-pyb00pt5	710	1	One	one	CD
cord-016293-pyb00pt5	710	2	of	of	IN
cord-016293-pyb00pt5	710	3	these	these	DT
cord-016293-pyb00pt5	710	4	cloned	clone	VBN
cord-016293-pyb00pt5	710	5	goats	goat	NNS
cord-016293-pyb00pt5	710	6	was	be	VBD
cord-016293-pyb00pt5	710	7	hormonally	hormonally	RB
cord-016293-pyb00pt5	710	8	induced	induce	VBN
cord-016293-pyb00pt5	710	9	to	to	TO
cord-016293-pyb00pt5	710	10	lactate	lactate	VB
cord-016293-pyb00pt5	710	11	.	.	.
cord-016293-pyb00pt5	711	1	This	this	DT
cord-016293-pyb00pt5	711	2	goat	goat	NN
cord-016293-pyb00pt5	711	3	secreted	secrete	VBD
cord-016293-pyb00pt5	711	4	3.7	3.7	CD
cord-016293-pyb00pt5	711	5	-	-	SYM
cord-016293-pyb00pt5	711	6	5.8	5.8	CD
cord-016293-pyb00pt5	711	7	grams	gram	NNS
cord-016293-pyb00pt5	711	8	per	per	IN
cord-016293-pyb00pt5	711	9	liter	liter	NN
cord-016293-pyb00pt5	711	10	of	of	IN
cord-016293-pyb00pt5	711	11	AT	at	NN
cord-016293-pyb00pt5	711	12	in	in	IN
cord-016293-pyb00pt5	711	13	her	-PRON-	PRP$
cord-016293-pyb00pt5	711	14	milk	milk	NN
cord-016293-pyb00pt5	711	15	.	.	.
cord-016293-pyb00pt5	712	1	This	this	DT
cord-016293-pyb00pt5	712	2	level	level	NN
cord-016293-pyb00pt5	712	3	of	of	IN
cord-016293-pyb00pt5	712	4	AT	at	IN
cord-016293-pyb00pt5	712	5	expression	expression	NN
cord-016293-pyb00pt5	712	6	was	be	VBD
cord-016293-pyb00pt5	712	7	comparable	comparable	JJ
cord-016293-pyb00pt5	712	8	to	to	IN
cord-016293-pyb00pt5	712	9	that	that	DT
cord-016293-pyb00pt5	712	10	detected	detect	VBN
cord-016293-pyb00pt5	712	11	in	in	IN
cord-016293-pyb00pt5	712	12	the	the	DT
cord-016293-pyb00pt5	712	13	milk	milk	NN
cord-016293-pyb00pt5	712	14	of	of	IN
cord-016293-pyb00pt5	712	15	transgenic	transgenic	JJ
cord-016293-pyb00pt5	712	16	goats	goat	NNS
cord-016293-pyb00pt5	712	17	from	from	IN
cord-016293-pyb00pt5	712	18	the	the	DT
cord-016293-pyb00pt5	712	19	same	same	JJ
cord-016293-pyb00pt5	712	20	line	line	NN
cord-016293-pyb00pt5	712	21	obtained	obtain	VBN
cord-016293-pyb00pt5	712	22	by	by	IN
cord-016293-pyb00pt5	712	23	natural	natural	JJ
cord-016293-pyb00pt5	712	24	breeding	breeding	NN
cord-016293-pyb00pt5	712	25	.	.	.
cord-016293-pyb00pt5	713	1	The	the	DT
cord-016293-pyb00pt5	713	2	successful	successful	JJ
cord-016293-pyb00pt5	713	3	secretion	secretion	NN
cord-016293-pyb00pt5	713	4	of	of	IN
cord-016293-pyb00pt5	713	5	AT	at	NN
cord-016293-pyb00pt5	713	6	in	in	IN
cord-016293-pyb00pt5	713	7	milk	milk	NN
cord-016293-pyb00pt5	713	8	was	be	VBD
cord-016293-pyb00pt5	713	9	a	a	DT
cord-016293-pyb00pt5	713	10	key	key	JJ
cord-016293-pyb00pt5	713	11	result	result	NN
cord-016293-pyb00pt5	713	12	because	because	IN
cord-016293-pyb00pt5	713	13	it	-PRON-	PRP
cord-016293-pyb00pt5	713	14	showed	show	VBD
cord-016293-pyb00pt5	713	15	that	that	IN
cord-016293-pyb00pt5	713	16	a	a	DT
cord-016293-pyb00pt5	713	17	cloned	clone	VBN
cord-016293-pyb00pt5	713	18	animal	animal	NN
cord-016293-pyb00pt5	713	19	could	could	MD
cord-016293-pyb00pt5	713	20	still	still	RB
cord-016293-pyb00pt5	713	21	synthesize	synthesize	VB
cord-016293-pyb00pt5	713	22	and	and	CC
cord-016293-pyb00pt5	713	23	secrete	secrete	VB
cord-016293-pyb00pt5	713	24	a	a	DT
cord-016293-pyb00pt5	713	25	foreign	foreign	JJ
cord-016293-pyb00pt5	713	26	protein	protein	NN
cord-016293-pyb00pt5	713	27	at	at	IN
cord-016293-pyb00pt5	713	28	the	the	DT
cord-016293-pyb00pt5	713	29	expected	expect	VBN
cord-016293-pyb00pt5	713	30	level	level	NN
cord-016293-pyb00pt5	713	31	.	.	.
cord-016293-pyb00pt5	714	1	It	-PRON-	PRP
cord-016293-pyb00pt5	714	2	will	will	MD
cord-016293-pyb00pt5	714	3	be	be	VB
cord-016293-pyb00pt5	714	4	interesting	interesting	JJ
cord-016293-pyb00pt5	714	5	to	to	TO
cord-016293-pyb00pt5	714	6	see	see	VB
cord-016293-pyb00pt5	714	7	if	if	IN
cord-016293-pyb00pt5	714	8	all	all	DT
cord-016293-pyb00pt5	714	9	three	three	CD
cord-016293-pyb00pt5	714	10	cloned	clone	VBN
cord-016293-pyb00pt5	714	11	goats	goat	NNS
cord-016293-pyb00pt5	714	12	secrete	secrete	VBP
cord-016293-pyb00pt5	714	13	human	human	NN
cord-016293-pyb00pt5	714	14	AT	at	IN
cord-016293-pyb00pt5	714	15	at	at	IN
cord-016293-pyb00pt5	714	16	the	the	DT
cord-016293-pyb00pt5	714	17	identical	identical	JJ
cord-016293-pyb00pt5	714	18	level	level	NN
cord-016293-pyb00pt5	714	19	.	.	.
cord-016293-pyb00pt5	715	1	If	if	IN
cord-016293-pyb00pt5	715	2	so	so	RB
cord-016293-pyb00pt5	715	3	,	,	,
cord-016293-pyb00pt5	715	4	then	then	RB
cord-016293-pyb00pt5	715	5	the	the	DT
cord-016293-pyb00pt5	715	6	goal	goal	NN
cord-016293-pyb00pt5	715	7	of	of	IN
cord-016293-pyb00pt5	715	8	creating	create	VBG
cord-016293-pyb00pt5	715	9	a	a	DT
cord-016293-pyb00pt5	715	10	herd	herd	NN
cord-016293-pyb00pt5	715	11	identical	identical	JJ
cord-016293-pyb00pt5	715	12	transgenic	transgenic	JJ
cord-016293-pyb00pt5	715	13	animals	animal	NNS
cord-016293-pyb00pt5	715	14	,	,	,
cord-016293-pyb00pt5	715	15	which	which	WDT
cord-016293-pyb00pt5	715	16	secrete	secrete	VBP
cord-016293-pyb00pt5	715	17	identical	identical	JJ
cord-016293-pyb00pt5	715	18	levels	level	NNS
cord-016293-pyb00pt5	715	19	of	of	IN
cord-016293-pyb00pt5	715	20	an	an	DT
cord-016293-pyb00pt5	715	21	important	important	JJ
cord-016293-pyb00pt5	715	22	pharmaceutical	pharmaceutical	NN
cord-016293-pyb00pt5	715	23	,	,	,
cord-016293-pyb00pt5	715	24	would	would	MD
cord-016293-pyb00pt5	715	25	become	become	VB
cord-016293-pyb00pt5	715	26	a	a	DT
cord-016293-pyb00pt5	715	27	reality	reality	NN
cord-016293-pyb00pt5	715	28	.	.	.
cord-016293-pyb00pt5	716	1	No	no	RB
cord-016293-pyb00pt5	716	2	longer	long	RBR
cord-016293-pyb00pt5	716	3	would	would	MD
cord-016293-pyb00pt5	716	4	variable	variable	VB
cord-016293-pyb00pt5	716	5	production	production	NN
cord-016293-pyb00pt5	716	6	levels	level	NNS
cord-016293-pyb00pt5	716	7	exist	exist	VBP
cord-016293-pyb00pt5	716	8	in	in	IN
cord-016293-pyb00pt5	716	9	subsequent	subsequent	JJ
cord-016293-pyb00pt5	716	10	generations	generation	NNS
cord-016293-pyb00pt5	716	11	due	due	JJ
cord-016293-pyb00pt5	716	12	to	to	IN
cord-016293-pyb00pt5	716	13	genetically	genetically	RB
cord-016293-pyb00pt5	716	14	similar	similar	JJ
cord-016293-pyb00pt5	716	15	but	but	CC
cord-016293-pyb00pt5	716	16	not	not	RB
cord-016293-pyb00pt5	716	17	identical	identical	JJ
cord-016293-pyb00pt5	716	18	animals	animal	NNS
cord-016293-pyb00pt5	716	19	.	.	.
cord-016293-pyb00pt5	717	1	This	this	DT
cord-016293-pyb00pt5	717	2	homogeneity	homogeneity	NN
cord-016293-pyb00pt5	717	3	would	would	MD
cord-016293-pyb00pt5	717	4	greatly	greatly	RB
cord-016293-pyb00pt5	717	5	aid	aid	VB
cord-016293-pyb00pt5	717	6	in	in	IN
cord-016293-pyb00pt5	717	7	the	the	DT
cord-016293-pyb00pt5	717	8	production	production	NN
cord-016293-pyb00pt5	717	9	and	and	CC
cord-016293-pyb00pt5	717	10	processing	processing	NN
cord-016293-pyb00pt5	717	11	of	of	IN
cord-016293-pyb00pt5	717	12	a	a	DT
cord-016293-pyb00pt5	717	13	uniform	uniform	JJ
cord-016293-pyb00pt5	717	14	product	product	NN
cord-016293-pyb00pt5	717	15	.	.	.
cord-016293-pyb00pt5	718	1	As	as	IN
cord-016293-pyb00pt5	718	2	nuclear	nuclear	JJ
cord-016293-pyb00pt5	718	3	transfer	transfer	NN
cord-016293-pyb00pt5	718	4	technology	technology	NN
cord-016293-pyb00pt5	718	5	continues	continue	VBZ
cord-016293-pyb00pt5	718	6	to	to	TO
cord-016293-pyb00pt5	718	7	be	be	VB
cord-016293-pyb00pt5	718	8	refined	refine	VBN
cord-016293-pyb00pt5	718	9	and	and	CC
cord-016293-pyb00pt5	718	10	applied	apply	VBN
cord-016293-pyb00pt5	718	11	to	to	IN
cord-016293-pyb00pt5	718	12	other	other	JJ
cord-016293-pyb00pt5	718	13	species	specie	NNS
cord-016293-pyb00pt5	718	14	,	,	,
cord-016293-pyb00pt5	718	15	it	-PRON-	PRP
cord-016293-pyb00pt5	718	16	may	may	MD
cord-016293-pyb00pt5	718	17	eventually	eventually	RB
cord-016293-pyb00pt5	718	18	replace	replace	VB
cord-016293-pyb00pt5	718	19	microinjection	microinjection	NN
cord-016293-pyb00pt5	718	20	as	as	IN
cord-016293-pyb00pt5	718	21	the	the	DT
cord-016293-pyb00pt5	718	22	method	method	NN
cord-016293-pyb00pt5	718	23	of	of	IN
cord-016293-pyb00pt5	718	24	choice	choice	NN
cord-016293-pyb00pt5	718	25	for	for	IN
cord-016293-pyb00pt5	718	26	generating	generate	VBG
cord-016293-pyb00pt5	718	27	transgenic	transgenic	JJ
cord-016293-pyb00pt5	718	28	livestock	livestock	NN
cord-016293-pyb00pt5	718	29	.	.	.
cord-016293-pyb00pt5	719	1	Nuclear	nuclear	JJ
cord-016293-pyb00pt5	719	2	transfer	transfer	NN
cord-016293-pyb00pt5	719	3	has	have	VBZ
cord-016293-pyb00pt5	719	4	a	a	DT
cord-016293-pyb00pt5	719	5	number	number	NN
cord-016293-pyb00pt5	719	6	of	of	IN
cord-016293-pyb00pt5	719	7	advantages	advantage	NNS
cord-016293-pyb00pt5	719	8	:	:	:
cord-016293-pyb00pt5	719	9	1	1	LS
cord-016293-pyb00pt5	719	10	)	)	-RRB-
cord-016293-pyb00pt5	719	11	nuclear	nuclear	JJ
cord-016293-pyb00pt5	719	12	transfer	transfer	NN
cord-016293-pyb00pt5	719	13	is	be	VBZ
cord-016293-pyb00pt5	719	14	more	more	RBR
cord-016293-pyb00pt5	719	15	efficient	efficient	JJ
cord-016293-pyb00pt5	719	16	than	than	IN
cord-016293-pyb00pt5	719	17	microinjection	microinjection	NN
cord-016293-pyb00pt5	719	18	at	at	IN
cord-016293-pyb00pt5	719	19	producing	produce	VBG
cord-016293-pyb00pt5	719	20	a	a	DT
cord-016293-pyb00pt5	719	21	transgenic	transgenic	JJ
cord-016293-pyb00pt5	719	22	animal	animal	NN
cord-016293-pyb00pt5	719	23	,	,	,
cord-016293-pyb00pt5	719	24	2	2	CD
cord-016293-pyb00pt5	719	25	)	)	-RRB-
cord-016293-pyb00pt5	720	1	the	the	DT
cord-016293-pyb00pt5	720	2	fate	fate	NN
cord-016293-pyb00pt5	720	3	of	of	IN
cord-016293-pyb00pt5	720	4	the	the	DT
cord-016293-pyb00pt5	720	5	integrated	integrate	VBN
cord-016293-pyb00pt5	720	6	foreign	foreign	JJ
cord-016293-pyb00pt5	720	7	DNA	dna	NN
cord-016293-pyb00pt5	720	8	can	can	MD
cord-016293-pyb00pt5	720	9	be	be	VB
cord-016293-pyb00pt5	720	10	examined	examine	VBN
cord-016293-pyb00pt5	720	11	prior	prior	RB
cord-016293-pyb00pt5	720	12	to	to	IN
cord-016293-pyb00pt5	720	13	production	production	NN
cord-016293-pyb00pt5	720	14	of	of	IN
cord-016293-pyb00pt5	720	15	the	the	DT
cord-016293-pyb00pt5	720	16	transgenic	transgenic	JJ
cord-016293-pyb00pt5	720	17	animal	animal	NN
cord-016293-pyb00pt5	720	18	,	,	,
cord-016293-pyb00pt5	720	19	3	3	LS
cord-016293-pyb00pt5	720	20	)	)	-RRB-
cord-016293-pyb00pt5	720	21	the	the	DT
cord-016293-pyb00pt5	720	22	sex	sex	NN
cord-016293-pyb00pt5	720	23	of	of	IN
cord-016293-pyb00pt5	720	24	the	the	DT
cord-016293-pyb00pt5	720	25	transgenic	transgenic	JJ
cord-016293-pyb00pt5	720	26	animal	animal	NN
cord-016293-pyb00pt5	720	27	can	can	MD
cord-016293-pyb00pt5	720	28	be	be	VB
cord-016293-pyb00pt5	720	29	predetermined	predetermine	VBN
cord-016293-pyb00pt5	720	30	,	,	,
cord-016293-pyb00pt5	720	31	and	and	CC
cord-016293-pyb00pt5	720	32	4	4	LS
cord-016293-pyb00pt5	720	33	)	)	-RRB-
cord-016293-pyb00pt5	720	34	the	the	DT
cord-016293-pyb00pt5	720	35	problem	problem	NN
cord-016293-pyb00pt5	720	36	of	of	IN
cord-016293-pyb00pt5	720	37	mosaicism	mosaicism	NN
cord-016293-pyb00pt5	720	38	in	in	IN
cord-016293-pyb00pt5	720	39	first	first	JJ
cord-016293-pyb00pt5	720	40	generation	generation	NN
cord-016293-pyb00pt5	720	41	transgenic	transgenic	JJ
cord-016293-pyb00pt5	720	42	animals	animal	NNS
cord-016293-pyb00pt5	720	43	can	can	MD
cord-016293-pyb00pt5	720	44	be	be	VB
cord-016293-pyb00pt5	720	45	eliminated	eliminate	VBN
cord-016293-pyb00pt5	720	46	.	.	.
cord-016293-pyb00pt5	721	1	DNA	dna	NN
cord-016293-pyb00pt5	721	2	microinjection	microinjection	NN
cord-016293-pyb00pt5	721	3	has	have	VBZ
cord-016293-pyb00pt5	721	4	not	not	RB
cord-016293-pyb00pt5	721	5	been	be	VBN
cord-016293-pyb00pt5	721	6	a	a	DT
cord-016293-pyb00pt5	721	7	very	very	RB
cord-016293-pyb00pt5	721	8	efficient	efficient	JJ
cord-016293-pyb00pt5	721	9	mechanism	mechanism	NN
cord-016293-pyb00pt5	721	10	to	to	TO
cord-016293-pyb00pt5	721	11	produce	produce	VB
cord-016293-pyb00pt5	721	12	transgenic	transgenic	JJ
cord-016293-pyb00pt5	721	13	mammals	mammal	NNS
cord-016293-pyb00pt5	721	14	.	.	.
cord-016293-pyb00pt5	722	1	However	however	RB
cord-016293-pyb00pt5	722	2	,	,	,
cord-016293-pyb00pt5	722	3	in	in	IN
cord-016293-pyb00pt5	722	4	November	November	NNP
cord-016293-pyb00pt5	722	5	,	,	,
cord-016293-pyb00pt5	722	6	1998	1998	CD
cord-016293-pyb00pt5	722	7	,	,	,
cord-016293-pyb00pt5	722	8	a	a	DT
cord-016293-pyb00pt5	722	9	team	team	NN
cord-016293-pyb00pt5	722	10	of	of	IN
cord-016293-pyb00pt5	722	11	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	722	12	researchers	researcher	NNS
cord-016293-pyb00pt5	722	13	reported	report	VBD
cord-016293-pyb00pt5	722	14	a	a	DT
cord-016293-pyb00pt5	722	15	nearly	nearly	RB
cord-016293-pyb00pt5	722	16	100	100	CD
cord-016293-pyb00pt5	722	17	%	%	NN
cord-016293-pyb00pt5	722	18	efficient	efficient	JJ
cord-016293-pyb00pt5	722	19	method	method	NN
cord-016293-pyb00pt5	722	20	for	for	IN
cord-016293-pyb00pt5	722	21	generating	generate	VBG
cord-016293-pyb00pt5	722	22	transgenic	transgenic	JJ
cord-016293-pyb00pt5	722	23	cattle	cattle	NNS
cord-016293-pyb00pt5	722	24	.	.	.
cord-016293-pyb00pt5	723	1	The	the	DT
cord-016293-pyb00pt5	723	2	established	establish	VBN
cord-016293-pyb00pt5	723	3	method	method	NN
cord-016293-pyb00pt5	723	4	of	of	IN
cord-016293-pyb00pt5	723	5	cattle	cattle	NNS
cord-016293-pyb00pt5	723	6	transgenes	transgene	NNS
cord-016293-pyb00pt5	723	7	involves	involve	VBZ
cord-016293-pyb00pt5	723	8	injecting	inject	VBG
cord-016293-pyb00pt5	723	9	DNA	DNA	NNP
cord-016293-pyb00pt5	723	10	into	into	IN
cord-016293-pyb00pt5	723	11	the	the	DT
cord-016293-pyb00pt5	723	12	pronuclei	pronuclei	NN
cord-016293-pyb00pt5	723	13	of	of	IN
cord-016293-pyb00pt5	723	14	a	a	DT
cord-016293-pyb00pt5	723	15	fertilized	fertilize	VBN
cord-016293-pyb00pt5	723	16	egg	egg	NN
cord-016293-pyb00pt5	723	17	or	or	CC
cord-016293-pyb00pt5	723	18	zygote	zygote	NN
cord-016293-pyb00pt5	723	19	.	.	.
cord-016293-pyb00pt5	724	1	In	in	IN
cord-016293-pyb00pt5	724	2	contrast	contrast	NN
cord-016293-pyb00pt5	724	3	,	,	,
cord-016293-pyb00pt5	724	4	the	the	DT
cord-016293-pyb00pt5	724	5	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	724	6	team	team	NN
cord-016293-pyb00pt5	724	7	injected	inject	VBD
cord-016293-pyb00pt5	724	8	a	a	DT
cord-016293-pyb00pt5	724	9	replication	replication	NN
cord-016293-pyb00pt5	724	10	-	-	HYPH
cord-016293-pyb00pt5	724	11	defective	defective	JJ
cord-016293-pyb00pt5	724	12	retroviral	retroviral	NN
cord-016293-pyb00pt5	724	13	vector	vector	NN
cord-016293-pyb00pt5	724	14	into	into	IN
cord-016293-pyb00pt5	724	15	the	the	DT
cord-016293-pyb00pt5	724	16	perivitelline	perivitelline	JJ
cord-016293-pyb00pt5	724	17	space	space	NN
cord-016293-pyb00pt5	724	18	of	of	IN
cord-016293-pyb00pt5	724	19	an	an	DT
cord-016293-pyb00pt5	724	20	unfertilized	unfertilized	JJ
cord-016293-pyb00pt5	724	21	oocyte	oocyte	NN
cord-016293-pyb00pt5	724	22	.	.	.
cord-016293-pyb00pt5	725	1	The	the	DT
cord-016293-pyb00pt5	725	2	perivitelline	perivitelline	NN
cord-016293-pyb00pt5	725	3	space	space	NN
cord-016293-pyb00pt5	725	4	is	be	VBZ
cord-016293-pyb00pt5	725	5	the	the	DT
cord-016293-pyb00pt5	725	6	region	region	NN
cord-016293-pyb00pt5	725	7	between	between	IN
cord-016293-pyb00pt5	725	8	the	the	DT
cord-016293-pyb00pt5	725	9	oocyte	oocyte	NN
cord-016293-pyb00pt5	725	10	membrane	membrane	NN
cord-016293-pyb00pt5	725	11	and	and	CC
cord-016293-pyb00pt5	725	12	the	the	DT
cord-016293-pyb00pt5	725	13	protective	protective	JJ
cord-016293-pyb00pt5	725	14	coating	coating	NN
cord-016293-pyb00pt5	725	15	surrounding	surround	VBG
cord-016293-pyb00pt5	725	16	the	the	DT
cord-016293-pyb00pt5	725	17	oocyte	oocyte	NN
cord-016293-pyb00pt5	725	18	known	know	VBN
cord-016293-pyb00pt5	725	19	as	as	IN
cord-016293-pyb00pt5	725	20	the	the	DT
cord-016293-pyb00pt5	725	21	zona	zona	NNP
cord-016293-pyb00pt5	725	22	pellucida	pellucida	NN
cord-016293-pyb00pt5	725	23	.	.	.
cord-016293-pyb00pt5	726	1	In	in	IN
cord-016293-pyb00pt5	726	2	addition	addition	NN
cord-016293-pyb00pt5	726	3	to	to	IN
cord-016293-pyb00pt5	726	4	ES	ES	NNP
cord-016293-pyb00pt5	726	5	(	(	-LRB-
cord-016293-pyb00pt5	726	6	embryonic	embryonic	JJ
cord-016293-pyb00pt5	726	7	stem	stem	NN
cord-016293-pyb00pt5	726	8	)	)	-RRB-
cord-016293-pyb00pt5	726	9	cells	cell	NNS
cord-016293-pyb00pt5	727	1	other	other	JJ
cord-016293-pyb00pt5	727	2	sources	source	NNS
cord-016293-pyb00pt5	727	3	of	of	IN
cord-016293-pyb00pt5	727	4	donor	donor	NN
cord-016293-pyb00pt5	727	5	nuclei	nucleus	NNS
cord-016293-pyb00pt5	727	6	for	for	IN
cord-016293-pyb00pt5	727	7	nuclear	nuclear	JJ
cord-016293-pyb00pt5	727	8	transfer	transfer	NN
cord-016293-pyb00pt5	727	9	might	may	MD
cord-016293-pyb00pt5	727	10	be	be	VB
cord-016293-pyb00pt5	727	11	used	use	VBN
cord-016293-pyb00pt5	727	12	such	such	JJ
cord-016293-pyb00pt5	727	13	as	as	IN
cord-016293-pyb00pt5	727	14	embryonic	embryonic	JJ
cord-016293-pyb00pt5	727	15	cell	cell	NN
cord-016293-pyb00pt5	727	16	lines	line	NNS
cord-016293-pyb00pt5	727	17	,	,	,
cord-016293-pyb00pt5	727	18	primordial	primordial	JJ
cord-016293-pyb00pt5	727	19	germ	germ	NN
cord-016293-pyb00pt5	727	20	cells	cell	NNS
cord-016293-pyb00pt5	727	21	,	,	,
cord-016293-pyb00pt5	727	22	or	or	CC
cord-016293-pyb00pt5	727	23	spermatogonia	spermatogonia	NNP
cord-016293-pyb00pt5	727	24	to	to	TO
cord-016293-pyb00pt5	727	25	produce	produce	VB
cord-016293-pyb00pt5	727	26	offspring	offspring	NN
cord-016293-pyb00pt5	727	27	.	.	.
cord-016293-pyb00pt5	728	1	The	the	DT
cord-016293-pyb00pt5	728	2	utility	utility	NN
cord-016293-pyb00pt5	728	3	of	of	IN
cord-016293-pyb00pt5	728	4	ES	ES	NNP
cord-016293-pyb00pt5	728	5	cells	cell	NNS
cord-016293-pyb00pt5	728	6	or	or	CC
cord-016293-pyb00pt5	728	7	related	relate	VBN
cord-016293-pyb00pt5	728	8	methodologies	methodology	NNS
cord-016293-pyb00pt5	728	9	to	to	TO
cord-016293-pyb00pt5	728	10	provide	provide	VB
cord-016293-pyb00pt5	728	11	efficient	efficient	JJ
cord-016293-pyb00pt5	728	12	and	and	CC
cord-016293-pyb00pt5	728	13	targeted	target	VBN
cord-016293-pyb00pt5	728	14	in	in	IN
cord-016293-pyb00pt5	728	15	vivo	vivo	NN
cord-016293-pyb00pt5	728	16	genetic	genetic	JJ
cord-016293-pyb00pt5	728	17	manipulations	manipulation	NNS
cord-016293-pyb00pt5	728	18	offer	offer	VBP
cord-016293-pyb00pt5	728	19	the	the	DT
cord-016293-pyb00pt5	728	20	prospects	prospect	NNS
cord-016293-pyb00pt5	728	21	of	of	IN
cord-016293-pyb00pt5	728	22	profoundly	profoundly	RB
cord-016293-pyb00pt5	728	23	useful	useful	JJ
cord-016293-pyb00pt5	728	24	animal	animal	NN
cord-016293-pyb00pt5	728	25	models	model	NNS
cord-016293-pyb00pt5	728	26	for	for	IN
cord-016293-pyb00pt5	728	27	biomedical	biomedical	JJ
cord-016293-pyb00pt5	728	28	,	,	,
cord-016293-pyb00pt5	728	29	biological	biological	JJ
cord-016293-pyb00pt5	728	30	and	and	CC
cord-016293-pyb00pt5	728	31	agricultural	agricultural	JJ
cord-016293-pyb00pt5	728	32	applications	application	NNS
cord-016293-pyb00pt5	728	33	.	.	.
cord-016293-pyb00pt5	729	1	The	the	DT
cord-016293-pyb00pt5	729	2	road	road	NN
cord-016293-pyb00pt5	729	3	to	to	IN
cord-016293-pyb00pt5	729	4	such	such	JJ
cord-016293-pyb00pt5	729	5	success	success	NN
cord-016293-pyb00pt5	729	6	has	have	VBZ
cord-016293-pyb00pt5	729	7	been	be	VBN
cord-016293-pyb00pt5	729	8	most	most	RBS
cord-016293-pyb00pt5	729	9	challenging	challenging	JJ
cord-016293-pyb00pt5	729	10	,	,	,
cord-016293-pyb00pt5	729	11	but	but	CC
cord-016293-pyb00pt5	729	12	recent	recent	JJ
cord-016293-pyb00pt5	729	13	developments	development	NNS
cord-016293-pyb00pt5	729	14	in	in	IN
cord-016293-pyb00pt5	729	15	this	this	DT
cord-016293-pyb00pt5	729	16	field	field	NN
cord-016293-pyb00pt5	729	17	are	be	VBP
cord-016293-pyb00pt5	729	18	extremely	extremely	RB
cord-016293-pyb00pt5	729	19	encouraging	encouraging	JJ
cord-016293-pyb00pt5	729	20	.	.	.
cord-016293-pyb00pt5	730	1	With	with	IN
cord-016293-pyb00pt5	730	2	the	the	DT
cord-016293-pyb00pt5	730	3	May	May	NNP
cord-016293-pyb00pt5	730	4	1999	1999	CD
cord-016293-pyb00pt5	730	5	announcement	announcement	NN
cord-016293-pyb00pt5	730	6	of	of	IN
cord-016293-pyb00pt5	730	7	Geron	Geron	NNP
cord-016293-pyb00pt5	730	8	buying	buy	VBG
cord-016293-pyb00pt5	730	9	out	out	RP
cord-016293-pyb00pt5	730	10	Ian	Ian	NNP
cord-016293-pyb00pt5	730	11	Wilmuts	Wilmuts	NNP
cord-016293-pyb00pt5	730	12	company	company	NN
cord-016293-pyb00pt5	730	13	Roslin	Roslin	NNP
cord-016293-pyb00pt5	730	14	BioMed	BioMed	NNP
cord-016293-pyb00pt5	730	15	,	,	,
cord-016293-pyb00pt5	730	16	they	-PRON-	PRP
cord-016293-pyb00pt5	730	17	declared	declare	VBD
cord-016293-pyb00pt5	730	18	it	-PRON-	PRP
cord-016293-pyb00pt5	730	19	the	the	DT
cord-016293-pyb00pt5	730	20	dawn	dawn	NN
cord-016293-pyb00pt5	730	21	of	of	IN
cord-016293-pyb00pt5	730	22	an	an	DT
cord-016293-pyb00pt5	730	23	new	new	JJ
cord-016293-pyb00pt5	730	24	era	era	NN
cord-016293-pyb00pt5	730	25	in	in	IN
cord-016293-pyb00pt5	730	26	biomedical	biomedical	JJ
cord-016293-pyb00pt5	730	27	research	research	NN
cord-016293-pyb00pt5	730	28	.	.	.
cord-016293-pyb00pt5	731	1	Geron	Geron	NNP
cord-016293-pyb00pt5	731	2	's	's	POS
cord-016293-pyb00pt5	731	3	technologies	technology	NNS
cord-016293-pyb00pt5	731	4	for	for	IN
cord-016293-pyb00pt5	731	5	deriving	derive	VBG
cord-016293-pyb00pt5	731	6	transplantable	transplantable	JJ
cord-016293-pyb00pt5	731	7	cells	cell	NNS
cord-016293-pyb00pt5	731	8	from	from	IN
cord-016293-pyb00pt5	731	9	human	human	JJ
cord-016293-pyb00pt5	731	10	pluripotent	pluripotent	JJ
cord-016293-pyb00pt5	731	11	stem	stem	NN
cord-016293-pyb00pt5	731	12	cells	cell	NNS
cord-016293-pyb00pt5	731	13	(	(	-LRB-
cord-016293-pyb00pt5	731	14	hPSCs	hpscs	$
cord-016293-pyb00pt5	731	15	)	)	-RRB-
cord-016293-pyb00pt5	731	16	and	and	CC
cord-016293-pyb00pt5	731	17	extending	extend	VBG
cord-016293-pyb00pt5	731	18	their	-PRON-	PRP$
cord-016293-pyb00pt5	731	19	replicative	replicative	JJ
cord-016293-pyb00pt5	731	20	capacity	capacity	NN
cord-016293-pyb00pt5	731	21	with	with	IN
cord-016293-pyb00pt5	731	22	telomerase	telomerase	NN
cord-016293-pyb00pt5	731	23	was	be	VBD
cord-016293-pyb00pt5	731	24	combined	combine	VBN
cord-016293-pyb00pt5	731	25	with	with	IN
cord-016293-pyb00pt5	731	26	the	the	DT
cord-016293-pyb00pt5	731	27	Roslin	Roslin	NNP
cord-016293-pyb00pt5	731	28	Institute	Institute	NNP
cord-016293-pyb00pt5	731	29	nuclear	nuclear	JJ
cord-016293-pyb00pt5	731	30	transfer	transfer	NN
cord-016293-pyb00pt5	731	31	technology	technology	NN
cord-016293-pyb00pt5	731	32	,	,	,
cord-016293-pyb00pt5	731	33	the	the	DT
cord-016293-pyb00pt5	731	34	technology	technology	NN
cord-016293-pyb00pt5	731	35	that	that	WDT
cord-016293-pyb00pt5	731	36	produced	produce	VBD
cord-016293-pyb00pt5	731	37	Dolly	Dolly	NNP
cord-016293-pyb00pt5	731	38	the	the	DT
cord-016293-pyb00pt5	731	39	cloned	clone	VBN
cord-016293-pyb00pt5	731	40	sheep	sheep	NN
cord-016293-pyb00pt5	731	41	.	.	.
cord-016293-pyb00pt5	732	1	The	the	DT
cord-016293-pyb00pt5	732	2	goal	goal	NN
cord-016293-pyb00pt5	732	3	was	be	VBD
cord-016293-pyb00pt5	732	4	to	to	TO
cord-016293-pyb00pt5	732	5	produce	produce	VB
cord-016293-pyb00pt5	732	6	transplantable	transplantable	JJ
cord-016293-pyb00pt5	732	7	,	,	,
cord-016293-pyb00pt5	732	8	tissue	tissue	NN
cord-016293-pyb00pt5	732	9	-	-	HYPH
cord-016293-pyb00pt5	732	10	matched	match	VBN
cord-016293-pyb00pt5	732	11	cells	cell	NNS
cord-016293-pyb00pt5	732	12	that	that	WDT
cord-016293-pyb00pt5	732	13	provide	provide	VBP
cord-016293-pyb00pt5	732	14	extended	extended	JJ
cord-016293-pyb00pt5	732	15	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	732	16	benefits	benefit	NNS
cord-016293-pyb00pt5	732	17	without	without	IN
cord-016293-pyb00pt5	732	18	triggering	trigger	VBG
cord-016293-pyb00pt5	732	19	immune	immune	JJ
cord-016293-pyb00pt5	732	20	rejection	rejection	NN
cord-016293-pyb00pt5	732	21	.	.	.
cord-016293-pyb00pt5	733	1	Such	such	JJ
cord-016293-pyb00pt5	733	2	cells	cell	NNS
cord-016293-pyb00pt5	733	3	could	could	MD
cord-016293-pyb00pt5	733	4	be	be	VB
cord-016293-pyb00pt5	733	5	used	use	VBN
cord-016293-pyb00pt5	733	6	to	to	TO
cord-016293-pyb00pt5	733	7	treat	treat	VB
cord-016293-pyb00pt5	733	8	numerous	numerous	JJ
cord-016293-pyb00pt5	733	9	major	major	JJ
cord-016293-pyb00pt5	733	10	chronic	chronic	JJ
cord-016293-pyb00pt5	733	11	degenerative	degenerative	JJ
cord-016293-pyb00pt5	733	12	diseases	disease	NNS
cord-016293-pyb00pt5	733	13	and	and	CC
cord-016293-pyb00pt5	733	14	conditions	condition	NNS
cord-016293-pyb00pt5	733	15	such	such	JJ
cord-016293-pyb00pt5	733	16	as	as	IN
cord-016293-pyb00pt5	733	17	heart	heart	NN
cord-016293-pyb00pt5	733	18	disease	disease	NN
cord-016293-pyb00pt5	733	19	,	,	,
cord-016293-pyb00pt5	733	20	stroke	stroke	NN
cord-016293-pyb00pt5	733	21	,	,	,
cord-016293-pyb00pt5	733	22	Parkinson	Parkinson	NNP
cord-016293-pyb00pt5	733	23	's	's	POS
cord-016293-pyb00pt5	733	24	disease	disease	NN
cord-016293-pyb00pt5	733	25	,	,	,
cord-016293-pyb00pt5	733	26	Alzheimer	Alzheimer	NNP
cord-016293-pyb00pt5	733	27	's	's	POS
cord-016293-pyb00pt5	733	28	disease	disease	NN
cord-016293-pyb00pt5	733	29	,	,	,
cord-016293-pyb00pt5	733	30	spinal	spinal	JJ
cord-016293-pyb00pt5	733	31	cord	cord	NN
cord-016293-pyb00pt5	733	32	injury	injury	NN
cord-016293-pyb00pt5	733	33	,	,	,
cord-016293-pyb00pt5	733	34	diabetes	diabetes	NN
cord-016293-pyb00pt5	733	35	,	,	,
cord-016293-pyb00pt5	733	36	osteoarthritis	osteoarthritis	NN
cord-016293-pyb00pt5	733	37	,	,	,
cord-016293-pyb00pt5	733	38	bone	bone	NN
cord-016293-pyb00pt5	733	39	marrow	marrow	NN
cord-016293-pyb00pt5	733	40	failure	failure	NN
cord-016293-pyb00pt5	733	41	and	and	CC
cord-016293-pyb00pt5	733	42	burns	burn	NNS
cord-016293-pyb00pt5	733	43	.	.	.
cord-016293-pyb00pt5	734	1	The	the	DT
cord-016293-pyb00pt5	734	2	stem	stem	NN
cord-016293-pyb00pt5	734	3	cell	cell	NN
cord-016293-pyb00pt5	734	4	is	be	VBZ
cord-016293-pyb00pt5	734	5	a	a	DT
cord-016293-pyb00pt5	734	6	unique	unique	JJ
cord-016293-pyb00pt5	734	7	and	and	CC
cord-016293-pyb00pt5	734	8	essential	essential	JJ
cord-016293-pyb00pt5	734	9	cell	cell	NN
cord-016293-pyb00pt5	734	10	type	type	NN
cord-016293-pyb00pt5	734	11	found	find	VBN
cord-016293-pyb00pt5	734	12	in	in	IN
cord-016293-pyb00pt5	734	13	animals	animal	NNS
cord-016293-pyb00pt5	734	14	.	.	.
cord-016293-pyb00pt5	735	1	Many	many	JJ
cord-016293-pyb00pt5	735	2	kinds	kind	NNS
cord-016293-pyb00pt5	735	3	of	of	IN
cord-016293-pyb00pt5	735	4	stem	stem	NN
cord-016293-pyb00pt5	735	5	cells	cell	NNS
cord-016293-pyb00pt5	735	6	are	be	VBP
cord-016293-pyb00pt5	735	7	found	find	VBN
cord-016293-pyb00pt5	735	8	in	in	IN
cord-016293-pyb00pt5	735	9	the	the	DT
cord-016293-pyb00pt5	735	10	body	body	NN
cord-016293-pyb00pt5	735	11	,	,	,
cord-016293-pyb00pt5	735	12	with	with	IN
cord-016293-pyb00pt5	735	13	some	some	DT
cord-016293-pyb00pt5	735	14	more	more	RBR
cord-016293-pyb00pt5	735	15	differentiated	differentiated	JJ
cord-016293-pyb00pt5	735	16	,	,	,
cord-016293-pyb00pt5	735	17	or	or	CC
cord-016293-pyb00pt5	735	18	committed	commit	VBD
cord-016293-pyb00pt5	735	19	,	,	,
cord-016293-pyb00pt5	735	20	to	to	IN
cord-016293-pyb00pt5	735	21	a	a	DT
cord-016293-pyb00pt5	735	22	particular	particular	JJ
cord-016293-pyb00pt5	735	23	function	function	NN
cord-016293-pyb00pt5	735	24	than	than	IN
cord-016293-pyb00pt5	735	25	others	other	NNS
cord-016293-pyb00pt5	735	26	.	.	.
cord-016293-pyb00pt5	736	1	In	in	IN
cord-016293-pyb00pt5	736	2	other	other	JJ
cord-016293-pyb00pt5	736	3	words	word	NNS
cord-016293-pyb00pt5	736	4	,	,	,
cord-016293-pyb00pt5	736	5	when	when	WRB
cord-016293-pyb00pt5	736	6	stem	stem	NN
cord-016293-pyb00pt5	736	7	cells	cell	NNS
cord-016293-pyb00pt5	736	8	divide	divide	VBP
cord-016293-pyb00pt5	736	9	,	,	,
cord-016293-pyb00pt5	736	10	some	some	DT
cord-016293-pyb00pt5	736	11	of	of	IN
cord-016293-pyb00pt5	736	12	the	the	DT
cord-016293-pyb00pt5	736	13	progeny	progeny	NN
cord-016293-pyb00pt5	736	14	mature	mature	VBP
cord-016293-pyb00pt5	736	15	into	into	IN
cord-016293-pyb00pt5	736	16	cells	cell	NNS
cord-016293-pyb00pt5	736	17	of	of	IN
cord-016293-pyb00pt5	736	18	a	a	DT
cord-016293-pyb00pt5	736	19	specific	specific	JJ
cord-016293-pyb00pt5	736	20	type	type	NN
cord-016293-pyb00pt5	736	21	(	(	-LRB-
cord-016293-pyb00pt5	736	22	heart	heart	NN
cord-016293-pyb00pt5	736	23	,	,	,
cord-016293-pyb00pt5	736	24	muscle	muscle	NN
cord-016293-pyb00pt5	736	25	,	,	,
cord-016293-pyb00pt5	736	26	blood	blood	NN
cord-016293-pyb00pt5	736	27	,	,	,
cord-016293-pyb00pt5	736	28	or	or	CC
cord-016293-pyb00pt5	736	29	brain	brain	NN
cord-016293-pyb00pt5	736	30	cells	cell	NNS
cord-016293-pyb00pt5	736	31	)	)	-RRB-
cord-016293-pyb00pt5	736	32	,	,	,
cord-016293-pyb00pt5	736	33	while	while	IN
cord-016293-pyb00pt5	736	34	others	other	NNS
cord-016293-pyb00pt5	736	35	remain	remain	VBP
cord-016293-pyb00pt5	736	36	stem	stem	NN
cord-016293-pyb00pt5	736	37	cells	cell	NNS
cord-016293-pyb00pt5	736	38	,	,	,
cord-016293-pyb00pt5	736	39	ready	ready	JJ
cord-016293-pyb00pt5	736	40	to	to	TO
cord-016293-pyb00pt5	736	41	repair	repair	VB
cord-016293-pyb00pt5	736	42	some	some	DT
cord-016293-pyb00pt5	736	43	of	of	IN
cord-016293-pyb00pt5	736	44	the	the	DT
cord-016293-pyb00pt5	736	45	everyday	everyday	JJ
cord-016293-pyb00pt5	736	46	wear	wear	NN
cord-016293-pyb00pt5	736	47	and	and	CC
cord-016293-pyb00pt5	736	48	tear	tear	VB
cord-016293-pyb00pt5	736	49	undergone	undergone	NN
cord-016293-pyb00pt5	736	50	by	by	IN
cord-016293-pyb00pt5	736	51	our	-PRON-	PRP$
cord-016293-pyb00pt5	736	52	bodies	body	NNS
cord-016293-pyb00pt5	736	53	.	.	.
cord-016293-pyb00pt5	737	1	These	these	DT
cord-016293-pyb00pt5	737	2	stem	stem	NN
cord-016293-pyb00pt5	737	3	cells	cell	NNS
cord-016293-pyb00pt5	737	4	are	be	VBP
cord-016293-pyb00pt5	737	5	capable	capable	JJ
cord-016293-pyb00pt5	737	6	of	of	IN
cord-016293-pyb00pt5	737	7	continually	continually	RB
cord-016293-pyb00pt5	737	8	reproducing	reproduce	VBG
cord-016293-pyb00pt5	737	9	themselves	-PRON-	PRP
cord-016293-pyb00pt5	737	10	and	and	CC
cord-016293-pyb00pt5	737	11	serve	serve	VB
cord-016293-pyb00pt5	737	12	to	to	TO
cord-016293-pyb00pt5	737	13	renew	renew	VB
cord-016293-pyb00pt5	737	14	tissue	tissue	NN
cord-016293-pyb00pt5	737	15	throughout	throughout	IN
cord-016293-pyb00pt5	737	16	an	an	DT
cord-016293-pyb00pt5	737	17	individual	individual	NN
cord-016293-pyb00pt5	737	18	's	's	POS
cord-016293-pyb00pt5	737	19	life	life	NN
cord-016293-pyb00pt5	737	20	.	.	.
cord-016293-pyb00pt5	738	1	For	for	IN
cord-016293-pyb00pt5	738	2	example	example	NN
cord-016293-pyb00pt5	738	3	,	,	,
cord-016293-pyb00pt5	738	4	they	-PRON-	PRP
cord-016293-pyb00pt5	738	5	continually	continually	RB
cord-016293-pyb00pt5	738	6	regenerate	regenerate	VBP
cord-016293-pyb00pt5	738	7	the	the	DT
cord-016293-pyb00pt5	738	8	lining	lining	NN
cord-016293-pyb00pt5	738	9	of	of	IN
cord-016293-pyb00pt5	738	10	the	the	DT
cord-016293-pyb00pt5	738	11	gut	gut	NN
cord-016293-pyb00pt5	738	12	,	,	,
cord-016293-pyb00pt5	738	13	revitalize	revitalize	VB
cord-016293-pyb00pt5	738	14	skin	skin	NN
cord-016293-pyb00pt5	738	15	,	,	,
cord-016293-pyb00pt5	738	16	and	and	CC
cord-016293-pyb00pt5	738	17	produce	produce	VB
cord-016293-pyb00pt5	738	18	a	a	DT
cord-016293-pyb00pt5	738	19	whole	whole	JJ
cord-016293-pyb00pt5	738	20	range	range	NN
cord-016293-pyb00pt5	738	21	of	of	IN
cord-016293-pyb00pt5	738	22	blood	blood	NN
cord-016293-pyb00pt5	738	23	cells	cell	NNS
cord-016293-pyb00pt5	738	24	.	.	.
cord-016293-pyb00pt5	739	1	Although	although	IN
cord-016293-pyb00pt5	739	2	the	the	DT
cord-016293-pyb00pt5	739	3	term	term	NN
cord-016293-pyb00pt5	739	4	"	"	``
cord-016293-pyb00pt5	739	5	stem	stem	NN
cord-016293-pyb00pt5	739	6	cell	cell	NN
cord-016293-pyb00pt5	739	7	"	"	''
cord-016293-pyb00pt5	739	8	commonly	commonly	RB
cord-016293-pyb00pt5	739	9	is	be	VBZ
cord-016293-pyb00pt5	739	10	used	use	VBN
cord-016293-pyb00pt5	739	11	to	to	TO
cord-016293-pyb00pt5	739	12	refer	refer	VB
cord-016293-pyb00pt5	739	13	to	to	IN
cord-016293-pyb00pt5	739	14	the	the	DT
cord-016293-pyb00pt5	739	15	cells	cell	NNS
cord-016293-pyb00pt5	739	16	within	within	IN
cord-016293-pyb00pt5	739	17	the	the	DT
cord-016293-pyb00pt5	739	18	adult	adult	NN
cord-016293-pyb00pt5	739	19	organism	organism	NN
cord-016293-pyb00pt5	739	20	that	that	WDT
cord-016293-pyb00pt5	739	21	renew	renew	VBP
cord-016293-pyb00pt5	739	22	tissue	tissue	NN
cord-016293-pyb00pt5	739	23	(	(	-LRB-
cord-016293-pyb00pt5	739	24	e.g.	e.g.	RB
cord-016293-pyb00pt5	739	25	,	,	,
cord-016293-pyb00pt5	739	26	hematopoietic	hematopoietic	JJ
cord-016293-pyb00pt5	739	27	stem	stem	NN
cord-016293-pyb00pt5	739	28	cells	cell	NNS
cord-016293-pyb00pt5	739	29	,	,	,
cord-016293-pyb00pt5	739	30	a	a	DT
cord-016293-pyb00pt5	739	31	type	type	NN
cord-016293-pyb00pt5	739	32	of	of	IN
cord-016293-pyb00pt5	739	33	cell	cell	NN
cord-016293-pyb00pt5	739	34	found	find	VBN
cord-016293-pyb00pt5	739	35	in	in	IN
cord-016293-pyb00pt5	739	36	the	the	DT
cord-016293-pyb00pt5	739	37	blood	blood	NN
cord-016293-pyb00pt5	739	38	)	)	-RRB-
cord-016293-pyb00pt5	739	39	,	,	,
cord-016293-pyb00pt5	739	40	the	the	DT
cord-016293-pyb00pt5	739	41	most	most	RBS
cord-016293-pyb00pt5	739	42	fundamental	fundamental	JJ
cord-016293-pyb00pt5	739	43	and	and	CC
cord-016293-pyb00pt5	739	44	extraordinary	extraordinary	JJ
cord-016293-pyb00pt5	739	45	of	of	IN
cord-016293-pyb00pt5	739	46	the	the	DT
cord-016293-pyb00pt5	739	47	stem	stem	NN
cord-016293-pyb00pt5	739	48	cells	cell	NNS
cord-016293-pyb00pt5	739	49	are	be	VBP
cord-016293-pyb00pt5	739	50	found	find	VBN
cord-016293-pyb00pt5	739	51	in	in	IN
cord-016293-pyb00pt5	739	52	the	the	DT
cord-016293-pyb00pt5	739	53	early	early	JJ
cord-016293-pyb00pt5	739	54	-	-	HYPH
cord-016293-pyb00pt5	739	55	stage	stage	NN
cord-016293-pyb00pt5	739	56	embryo	embryo	NN
cord-016293-pyb00pt5	739	57	.	.	.
cord-016293-pyb00pt5	740	1	These	these	DT
cord-016293-pyb00pt5	740	2	embryonic	embryonic	JJ
cord-016293-pyb00pt5	740	3	stem	stem	NN
cord-016293-pyb00pt5	740	4	(	(	-LRB-
cord-016293-pyb00pt5	740	5	ES	ES	NNP
cord-016293-pyb00pt5	740	6	)	)	-RRB-
cord-016293-pyb00pt5	740	7	cells	cell	NNS
cord-016293-pyb00pt5	740	8	,	,	,
cord-016293-pyb00pt5	740	9	unlike	unlike	IN
cord-016293-pyb00pt5	740	10	the	the	DT
cord-016293-pyb00pt5	740	11	more	more	RBR
cord-016293-pyb00pt5	740	12	differentiated	differentiated	JJ
cord-016293-pyb00pt5	740	13	adult	adult	NN
cord-016293-pyb00pt5	740	14	stem	stem	NN
cord-016293-pyb00pt5	740	15	cells	cell	NNS
cord-016293-pyb00pt5	740	16	or	or	CC
cord-016293-pyb00pt5	740	17	other	other	JJ
cord-016293-pyb00pt5	740	18	cell	cell	NN
cord-016293-pyb00pt5	740	19	types	type	NNS
cord-016293-pyb00pt5	740	20	,	,	,
cord-016293-pyb00pt5	740	21	retain	retain	VB
cord-016293-pyb00pt5	740	22	the	the	DT
cord-016293-pyb00pt5	740	23	special	special	JJ
cord-016293-pyb00pt5	740	24	ability	ability	NN
cord-016293-pyb00pt5	740	25	to	to	TO
cord-016293-pyb00pt5	740	26	develop	develop	VB
cord-016293-pyb00pt5	740	27	into	into	IN
cord-016293-pyb00pt5	740	28	nearly	nearly	RB
cord-016293-pyb00pt5	740	29	any	any	DT
cord-016293-pyb00pt5	740	30	cell	cell	NN
cord-016293-pyb00pt5	740	31	type	type	NN
cord-016293-pyb00pt5	740	32	.	.	.
cord-016293-pyb00pt5	741	1	Embryonic	embryonic	JJ
cord-016293-pyb00pt5	741	2	germ	germ	NN
cord-016293-pyb00pt5	741	3	(	(	-LRB-
cord-016293-pyb00pt5	741	4	EG	EG	NNP
cord-016293-pyb00pt5	741	5	)	)	-RRB-
cord-016293-pyb00pt5	741	6	cells	cell	NNS
cord-016293-pyb00pt5	741	7	,	,	,
cord-016293-pyb00pt5	741	8	which	which	WDT
cord-016293-pyb00pt5	741	9	originate	originate	VBP
cord-016293-pyb00pt5	741	10	from	from	IN
cord-016293-pyb00pt5	741	11	the	the	DT
cord-016293-pyb00pt5	741	12	primordial	primordial	JJ
cord-016293-pyb00pt5	741	13	reproductive	reproductive	JJ
cord-016293-pyb00pt5	741	14	cells	cell	NNS
cord-016293-pyb00pt5	741	15	of	of	IN
cord-016293-pyb00pt5	741	16	the	the	DT
cord-016293-pyb00pt5	741	17	developing	develop	VBG
cord-016293-pyb00pt5	741	18	fetus	fetus	NN
cord-016293-pyb00pt5	741	19	,	,	,
cord-016293-pyb00pt5	741	20	have	have	VBP
cord-016293-pyb00pt5	741	21	properties	property	NNS
cord-016293-pyb00pt5	741	22	similar	similar	JJ
cord-016293-pyb00pt5	741	23	to	to	IN
cord-016293-pyb00pt5	741	24	ES	ES	NNP
cord-016293-pyb00pt5	741	25	cells	cell	NNS
cord-016293-pyb00pt5	741	26	.	.	.
cord-016293-pyb00pt5	742	1	It	-PRON-	PRP
cord-016293-pyb00pt5	742	2	is	be	VBZ
cord-016293-pyb00pt5	742	3	the	the	DT
cord-016293-pyb00pt5	742	4	potentially	potentially	RB
cord-016293-pyb00pt5	742	5	unique	unique	JJ
cord-016293-pyb00pt5	742	6	versatility	versatility	NN
cord-016293-pyb00pt5	742	7	of	of	IN
cord-016293-pyb00pt5	742	8	the	the	DT
cord-016293-pyb00pt5	742	9	ES	es	NN
cord-016293-pyb00pt5	742	10	and	and	CC
cord-016293-pyb00pt5	742	11	EG	EG	NNP
cord-016293-pyb00pt5	742	12	cells	cell	NNS
cord-016293-pyb00pt5	742	13	derived	derive	VBN
cord-016293-pyb00pt5	742	14	,	,	,
cord-016293-pyb00pt5	742	15	respectively	respectively	RB
cord-016293-pyb00pt5	742	16	,	,	,
cord-016293-pyb00pt5	742	17	from	from	IN
cord-016293-pyb00pt5	742	18	the	the	DT
cord-016293-pyb00pt5	742	19	early	early	JJ
cord-016293-pyb00pt5	742	20	-	-	HYPH
cord-016293-pyb00pt5	742	21	stage	stage	NN
cord-016293-pyb00pt5	742	22	embryo	embryo	NN
cord-016293-pyb00pt5	742	23	and	and	CC
cord-016293-pyb00pt5	742	24	cadaveric	cadaveric	JJ
cord-016293-pyb00pt5	742	25	fetal	fetal	JJ
cord-016293-pyb00pt5	742	26	tissue	tissue	NN
cord-016293-pyb00pt5	742	27	that	that	WDT
cord-016293-pyb00pt5	742	28	presents	present	VBZ
cord-016293-pyb00pt5	742	29	such	such	JJ
cord-016293-pyb00pt5	742	30	unusual	unusual	JJ
cord-016293-pyb00pt5	742	31	scientific	scientific	JJ
cord-016293-pyb00pt5	742	32	and	and	CC
cord-016293-pyb00pt5	742	33	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	742	34	promise	promise	NN
cord-016293-pyb00pt5	742	35	.	.	.
cord-016293-pyb00pt5	743	1	Indeed	indeed	RB
cord-016293-pyb00pt5	743	2	,	,	,
cord-016293-pyb00pt5	743	3	scientists	scientist	NNS
cord-016293-pyb00pt5	743	4	have	have	VBP
cord-016293-pyb00pt5	743	5	long	long	RB
cord-016293-pyb00pt5	743	6	recognized	recognize	VBN
cord-016293-pyb00pt5	743	7	the	the	DT
cord-016293-pyb00pt5	743	8	possibility	possibility	NN
cord-016293-pyb00pt5	743	9	of	of	IN
cord-016293-pyb00pt5	743	10	using	use	VBG
cord-016293-pyb00pt5	743	11	such	such	JJ
cord-016293-pyb00pt5	743	12	cells	cell	NNS
cord-016293-pyb00pt5	743	13	to	to	TO
cord-016293-pyb00pt5	743	14	generate	generate	VB
cord-016293-pyb00pt5	743	15	more	more	JJR
cord-016293-pyb00pt5	743	16	specialized	specialized	JJ
cord-016293-pyb00pt5	743	17	cells	cell	NNS
cord-016293-pyb00pt5	743	18	or	or	CC
cord-016293-pyb00pt5	743	19	tissue	tissue	NN
cord-016293-pyb00pt5	743	20	,	,	,
cord-016293-pyb00pt5	743	21	which	which	WDT
cord-016293-pyb00pt5	743	22	could	could	MD
cord-016293-pyb00pt5	743	23	allow	allow	VB
cord-016293-pyb00pt5	743	24	the	the	DT
cord-016293-pyb00pt5	743	25	generation	generation	NN
cord-016293-pyb00pt5	743	26	of	of	IN
cord-016293-pyb00pt5	743	27	new	new	JJ
cord-016293-pyb00pt5	743	28	cells	cell	NNS
cord-016293-pyb00pt5	743	29	to	to	TO
cord-016293-pyb00pt5	743	30	be	be	VB
cord-016293-pyb00pt5	743	31	used	use	VBN
cord-016293-pyb00pt5	743	32	to	to	TO
cord-016293-pyb00pt5	743	33	treat	treat	VB
cord-016293-pyb00pt5	743	34	injuries	injury	NNS
cord-016293-pyb00pt5	743	35	or	or	CC
cord-016293-pyb00pt5	743	36	diseases	disease	NNS
cord-016293-pyb00pt5	743	37	,	,	,
cord-016293-pyb00pt5	743	38	such	such	JJ
cord-016293-pyb00pt5	743	39	as	as	IN
cord-016293-pyb00pt5	743	40	Alzheimer	Alzheimer	NNP
cord-016293-pyb00pt5	743	41	's	's	POS
cord-016293-pyb00pt5	743	42	disease	disease	NN
cord-016293-pyb00pt5	743	43	,	,	,
cord-016293-pyb00pt5	743	44	Parkinson	Parkinson	NNP
cord-016293-pyb00pt5	743	45	's	's	POS
cord-016293-pyb00pt5	743	46	disease	disease	NN
cord-016293-pyb00pt5	743	47	,	,	,
cord-016293-pyb00pt5	743	48	heart	heart	NN
cord-016293-pyb00pt5	743	49	disease	disease	NN
cord-016293-pyb00pt5	743	50	,	,	,
cord-016293-pyb00pt5	743	51	and	and	CC
cord-016293-pyb00pt5	743	52	kidney	kidney	NN
cord-016293-pyb00pt5	743	53	failure	failure	NN
cord-016293-pyb00pt5	743	54	.	.	.
cord-016293-pyb00pt5	744	1	Likewise	likewise	RB
cord-016293-pyb00pt5	744	2	,	,	,
cord-016293-pyb00pt5	744	3	scientists	scientist	NNS
cord-016293-pyb00pt5	744	4	regard	regard	VBP
cord-016293-pyb00pt5	744	5	these	these	DT
cord-016293-pyb00pt5	744	6	cells	cell	NNS
cord-016293-pyb00pt5	744	7	as	as	IN
cord-016293-pyb00pt5	744	8	an	an	DT
cord-016293-pyb00pt5	744	9	important	important	JJ
cord-016293-pyb00pt5	744	10	-perhaps	-perhaps	HYPH
cord-016293-pyb00pt5	744	11	essential	essential	JJ
cord-016293-pyb00pt5	744	12	-means	-mean	NNS
cord-016293-pyb00pt5	744	13	for	for	IN
cord-016293-pyb00pt5	744	14	understanding	understand	VBG
cord-016293-pyb00pt5	744	15	the	the	DT
cord-016293-pyb00pt5	744	16	earliest	early	JJS
cord-016293-pyb00pt5	744	17	stages	stage	NNS
cord-016293-pyb00pt5	744	18	of	of	IN
cord-016293-pyb00pt5	744	19	human	human	JJ
cord-016293-pyb00pt5	744	20	development	development	NN
cord-016293-pyb00pt5	744	21	and	and	CC
cord-016293-pyb00pt5	744	22	as	as	IN
cord-016293-pyb00pt5	744	23	an	an	DT
cord-016293-pyb00pt5	744	24	important	important	JJ
cord-016293-pyb00pt5	744	25	tool	tool	NN
cord-016293-pyb00pt5	744	26	in	in	IN
cord-016293-pyb00pt5	744	27	the	the	DT
cord-016293-pyb00pt5	744	28	development	development	NN
cord-016293-pyb00pt5	744	29	of	of	IN
cord-016293-pyb00pt5	744	30	life	life	NN
cord-016293-pyb00pt5	744	31	-	-	HYPH
cord-016293-pyb00pt5	744	32	saving	save	VBG
cord-016293-pyb00pt5	744	33	drugs	drug	NNS
cord-016293-pyb00pt5	744	34	and	and	CC
cord-016293-pyb00pt5	744	35	cell	cell	NN
cord-016293-pyb00pt5	744	36	-	-	HYPH
cord-016293-pyb00pt5	744	37	replacement	replacement	NN
cord-016293-pyb00pt5	744	38	therapies	therapy	NNS
cord-016293-pyb00pt5	744	39	to	to	TO
cord-016293-pyb00pt5	744	40	treat	treat	VB
cord-016293-pyb00pt5	744	41	disorders	disorder	NNS
cord-016293-pyb00pt5	744	42	caused	cause	VBN
cord-016293-pyb00pt5	744	43	by	by	IN
cord-016293-pyb00pt5	744	44	early	early	JJ
cord-016293-pyb00pt5	744	45	cell	cell	NN
cord-016293-pyb00pt5	744	46	death	death	NN
cord-016293-pyb00pt5	744	47	or	or	CC
cord-016293-pyb00pt5	744	48	impairment	impairment	NN
cord-016293-pyb00pt5	744	49	.	.	.
cord-016293-pyb00pt5	745	1	Geron	Geron	NNP
cord-016293-pyb00pt5	745	2	Corporation	Corporation	NNP
cord-016293-pyb00pt5	745	3	and	and	CC
cord-016293-pyb00pt5	745	4	its	-PRON-	PRP$
cord-016293-pyb00pt5	745	5	collaborators	collaborator	NNS
cord-016293-pyb00pt5	745	6	at	at	IN
cord-016293-pyb00pt5	745	7	the	the	DT
cord-016293-pyb00pt5	745	8	University	University	NNP
cord-016293-pyb00pt5	745	9	of	of	IN
cord-016293-pyb00pt5	745	10	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	746	1	-Madison	-Madison	NNP
cord-016293-pyb00pt5	747	1	(	(	-LRB-
cord-016293-pyb00pt5	747	2	Dr.	Dr.	NNP
cord-016293-pyb00pt5	747	3	James	James	NNP
cord-016293-pyb00pt5	747	4	A.	A.	NNP
cord-016293-pyb00pt5	747	5	Thomson	Thomson	NNP
cord-016293-pyb00pt5	747	6	)	)	-RRB-
cord-016293-pyb00pt5	747	7	and	and	CC
cord-016293-pyb00pt5	747	8	Johns	Johns	NNP
cord-016293-pyb00pt5	747	9	Hopkins	Hopkins	NNP
cord-016293-pyb00pt5	747	10	University	University	NNP
cord-016293-pyb00pt5	748	1	(	(	-LRB-
cord-016293-pyb00pt5	748	2	Dr.	Dr.	NNP
cord-016293-pyb00pt5	748	3	John	John	NNP
cord-016293-pyb00pt5	748	4	D.	D.	NNP
cord-016293-pyb00pt5	748	5	Gearhart	Gearhart	NNP
cord-016293-pyb00pt5	748	6	)	)	-RRB-
cord-016293-pyb00pt5	748	7	announced	announce	VBD
cord-016293-pyb00pt5	748	8	in	in	IN
cord-016293-pyb00pt5	748	9	November	November	NNP
cord-016293-pyb00pt5	748	10	1998	1998	CD
cord-016293-pyb00pt5	748	11	the	the	DT
cord-016293-pyb00pt5	748	12	first	first	JJ
cord-016293-pyb00pt5	748	13	successful	successful	JJ
cord-016293-pyb00pt5	748	14	derivation	derivation	NN
cord-016293-pyb00pt5	748	15	of	of	IN
cord-016293-pyb00pt5	748	16	hPSCs	hpscs	NN
cord-016293-pyb00pt5	748	17	from	from	IN
cord-016293-pyb00pt5	748	18	two	two	CD
cord-016293-pyb00pt5	748	19	sources	source	NNS
cord-016293-pyb00pt5	748	20	:	:	:
cord-016293-pyb00pt5	749	1	(	(	-LRB-
cord-016293-pyb00pt5	749	2	i	i	NN
cord-016293-pyb00pt5	749	3	)	)	-RRB-
cord-016293-pyb00pt5	749	4	human	human	JJ
cord-016293-pyb00pt5	749	5	embryonic	embryonic	JJ
cord-016293-pyb00pt5	749	6	stem	stem	NN
cord-016293-pyb00pt5	749	7	(	(	-LRB-
cord-016293-pyb00pt5	749	8	hES	hes	NN
cord-016293-pyb00pt5	749	9	)	)	-RRB-
cord-016293-pyb00pt5	749	10	cells	cell	NNS
cord-016293-pyb00pt5	749	11	derived	derive	VBN
cord-016293-pyb00pt5	749	12	from	from	IN
cord-016293-pyb00pt5	749	13	in	in	IN
cord-016293-pyb00pt5	749	14	vitro	vitro	FW
cord-016293-pyb00pt5	749	15	fertilized	fertilize	VBN
cord-016293-pyb00pt5	749	16	blastocysts	blastocyst	NNS
cord-016293-pyb00pt5	749	17	(	(	-LRB-
cord-016293-pyb00pt5	749	18	Thomson	Thomson	NNP
cord-016293-pyb00pt5	749	19	1998	1998	CD
cord-016293-pyb00pt5	749	20	)	)	-RRB-
cord-016293-pyb00pt5	749	21	and	and	CC
cord-016293-pyb00pt5	749	22	(	(	-LRB-
cord-016293-pyb00pt5	749	23	ii	ii	NN
cord-016293-pyb00pt5	749	24	)	)	-RRB-
cord-016293-pyb00pt5	749	25	human	human	JJ
cord-016293-pyb00pt5	749	26	embryonic	embryonic	JJ
cord-016293-pyb00pt5	749	27	germ	germ	NN
cord-016293-pyb00pt5	749	28	(	(	-LRB-
cord-016293-pyb00pt5	749	29	hEG	heg	NN
cord-016293-pyb00pt5	749	30	)	)	-RRB-
cord-016293-pyb00pt5	749	31	cells	cell	NNS
cord-016293-pyb00pt5	749	32	derived	derive	VBN
cord-016293-pyb00pt5	749	33	from	from	IN
cord-016293-pyb00pt5	749	34	fetal	fetal	JJ
cord-016293-pyb00pt5	749	35	material	material	NN
cord-016293-pyb00pt5	749	36	obtained	obtain	VBN
cord-016293-pyb00pt5	749	37	from	from	IN
cord-016293-pyb00pt5	749	38	medically	medically	RB
cord-016293-pyb00pt5	749	39	terminated	terminate	VBN
cord-016293-pyb00pt5	749	40	pregnancies	pregnancy	NNS
cord-016293-pyb00pt5	749	41	(	(	-LRB-
cord-016293-pyb00pt5	749	42	Shamblott	Shamblott	NNP
cord-016293-pyb00pt5	749	43	et	et	NNP
cord-016293-pyb00pt5	749	44	al	al	NNP
cord-016293-pyb00pt5	749	45	.	.	.
cord-016293-pyb00pt5	749	46	1998	1998	CD
cord-016293-pyb00pt5	749	47	)	)	-RRB-
cord-016293-pyb00pt5	749	48	.	.	.
cord-016293-pyb00pt5	750	1	Although	although	IN
cord-016293-pyb00pt5	750	2	derived	derive	VBN
cord-016293-pyb00pt5	750	3	from	from	IN
cord-016293-pyb00pt5	750	4	different	different	JJ
cord-016293-pyb00pt5	750	5	sources	source	NNS
cord-016293-pyb00pt5	750	6	by	by	IN
cord-016293-pyb00pt5	750	7	different	different	JJ
cord-016293-pyb00pt5	750	8	laboratory	laboratory	NN
cord-016293-pyb00pt5	750	9	processes	process	NNS
cord-016293-pyb00pt5	750	10	,	,	,
cord-016293-pyb00pt5	750	11	these	these	DT
cord-016293-pyb00pt5	750	12	two	two	CD
cord-016293-pyb00pt5	750	13	cell	cell	NN
cord-016293-pyb00pt5	750	14	types	type	NNS
cord-016293-pyb00pt5	750	15	share	share	VBP
cord-016293-pyb00pt5	750	16	certain	certain	JJ
cord-016293-pyb00pt5	750	17	characteristics	characteristic	NNS
cord-016293-pyb00pt5	750	18	but	but	CC
cord-016293-pyb00pt5	750	19	are	be	VBP
cord-016293-pyb00pt5	750	20	referred	refer	VBN
cord-016293-pyb00pt5	750	21	to	to	TO
cord-016293-pyb00pt5	750	22	collectively	collectively	RB
cord-016293-pyb00pt5	750	23	as	as	IN
cord-016293-pyb00pt5	750	24	human	human	JJ
cord-016293-pyb00pt5	750	25	pluripotent	pluripotent	JJ
cord-016293-pyb00pt5	750	26	stem	stem	NN
cord-016293-pyb00pt5	750	27	cells	cell	NNS
cord-016293-pyb00pt5	750	28	(	(	-LRB-
cord-016293-pyb00pt5	750	29	hPSCs	hpscs	CD
cord-016293-pyb00pt5	750	30	)	)	-RRB-
cord-016293-pyb00pt5	750	31	.	.	.
cord-016293-pyb00pt5	751	1	Because	because	IN
cord-016293-pyb00pt5	751	2	hES	hes	NN
cord-016293-pyb00pt5	751	3	cells	cell	NNS
cord-016293-pyb00pt5	751	4	have	have	VBP
cord-016293-pyb00pt5	751	5	been	be	VBN
cord-016293-pyb00pt5	751	6	more	more	RBR
cord-016293-pyb00pt5	751	7	thoroughly	thoroughly	RB
cord-016293-pyb00pt5	751	8	studied	study	VBN
cord-016293-pyb00pt5	751	9	,	,	,
cord-016293-pyb00pt5	751	10	the	the	DT
cord-016293-pyb00pt5	751	11	characteristics	characteristic	NNS
cord-016293-pyb00pt5	751	12	of	of	IN
cord-016293-pyb00pt5	751	13	hPSCs	hpsc	VBG
cord-016293-pyb00pt5	751	14	most	most	RBS
cord-016293-pyb00pt5	751	15	closely	closely	RB
cord-016293-pyb00pt5	751	16	describe	describe	VB
cord-016293-pyb00pt5	751	17	the	the	DT
cord-016293-pyb00pt5	751	18	known	know	VBN
cord-016293-pyb00pt5	751	19	properties	property	NNS
cord-016293-pyb00pt5	751	20	of	of	IN
cord-016293-pyb00pt5	751	21	hES	hes	NN
cord-016293-pyb00pt5	751	22	cells	cell	NNS
cord-016293-pyb00pt5	751	23	.	.	.
cord-016293-pyb00pt5	752	1	Stem	stem	NN
cord-016293-pyb00pt5	752	2	cells	cell	NNS
cord-016293-pyb00pt5	752	3	represent	represent	VBP
cord-016293-pyb00pt5	752	4	a	a	DT
cord-016293-pyb00pt5	752	5	tremendous	tremendous	JJ
cord-016293-pyb00pt5	752	6	scientific	scientific	JJ
cord-016293-pyb00pt5	752	7	advancement	advancement	NN
cord-016293-pyb00pt5	752	8	in	in	IN
cord-016293-pyb00pt5	752	9	two	two	CD
cord-016293-pyb00pt5	752	10	ways	way	NNS
cord-016293-pyb00pt5	752	11	:	:	:
cord-016293-pyb00pt5	752	12	first	first	RB
cord-016293-pyb00pt5	752	13	,	,	,
cord-016293-pyb00pt5	752	14	as	as	IN
cord-016293-pyb00pt5	752	15	a	a	DT
cord-016293-pyb00pt5	752	16	tool	tool	NN
cord-016293-pyb00pt5	752	17	to	to	TO
cord-016293-pyb00pt5	752	18	study	study	VB
cord-016293-pyb00pt5	752	19	developmental	developmental	JJ
cord-016293-pyb00pt5	752	20	and	and	CC
cord-016293-pyb00pt5	752	21	cell	cell	NN
cord-016293-pyb00pt5	752	22	biology	biology	NN
cord-016293-pyb00pt5	752	23	;	;	:
cord-016293-pyb00pt5	752	24	and	and	CC
cord-016293-pyb00pt5	752	25	second	second	RB
cord-016293-pyb00pt5	752	26	,	,	,
cord-016293-pyb00pt5	752	27	as	as	IN
cord-016293-pyb00pt5	752	28	the	the	DT
cord-016293-pyb00pt5	752	29	starting	starting	NN
cord-016293-pyb00pt5	752	30	point	point	NN
cord-016293-pyb00pt5	752	31	for	for	IN
cord-016293-pyb00pt5	752	32	therapies	therapy	NNS
cord-016293-pyb00pt5	752	33	to	to	TO
cord-016293-pyb00pt5	752	34	develop	develop	VB
cord-016293-pyb00pt5	752	35	medications	medication	NNS
cord-016293-pyb00pt5	752	36	to	to	TO
cord-016293-pyb00pt5	752	37	treat	treat	VB
cord-016293-pyb00pt5	752	38	some	some	DT
cord-016293-pyb00pt5	752	39	of	of	IN
cord-016293-pyb00pt5	752	40	the	the	DT
cord-016293-pyb00pt5	752	41	most	most	RBS
cord-016293-pyb00pt5	752	42	deadly	deadly	JJ
cord-016293-pyb00pt5	752	43	diseases	disease	NNS
cord-016293-pyb00pt5	752	44	.	.	.
cord-016293-pyb00pt5	753	1	The	the	DT
cord-016293-pyb00pt5	753	2	derivation	derivation	NN
cord-016293-pyb00pt5	753	3	of	of	IN
cord-016293-pyb00pt5	753	4	stem	stem	NN
cord-016293-pyb00pt5	753	5	cells	cell	NNS
cord-016293-pyb00pt5	753	6	is	be	VBZ
cord-016293-pyb00pt5	753	7	fundamental	fundamental	JJ
cord-016293-pyb00pt5	753	8	to	to	IN
cord-016293-pyb00pt5	753	9	scientific	scientific	JJ
cord-016293-pyb00pt5	753	10	research	research	NN
cord-016293-pyb00pt5	753	11	in	in	IN
cord-016293-pyb00pt5	753	12	understanding	understand	VBG
cord-016293-pyb00pt5	753	13	basic	basic	JJ
cord-016293-pyb00pt5	753	14	cellular	cellular	JJ
cord-016293-pyb00pt5	753	15	and	and	CC
cord-016293-pyb00pt5	753	16	embryonic	embryonic	JJ
cord-016293-pyb00pt5	753	17	development	development	NN
cord-016293-pyb00pt5	753	18	.	.	.
cord-016293-pyb00pt5	754	1	Observing	observe	VBG
cord-016293-pyb00pt5	754	2	the	the	DT
cord-016293-pyb00pt5	754	3	development	development	NN
cord-016293-pyb00pt5	754	4	of	of	IN
cord-016293-pyb00pt5	754	5	stem	stem	NN
cord-016293-pyb00pt5	754	6	cells	cell	NNS
cord-016293-pyb00pt5	754	7	as	as	IN
cord-016293-pyb00pt5	754	8	they	-PRON-	PRP
cord-016293-pyb00pt5	754	9	differentiate	differentiate	VBP
cord-016293-pyb00pt5	754	10	into	into	IN
cord-016293-pyb00pt5	754	11	a	a	DT
cord-016293-pyb00pt5	754	12	number	number	NN
cord-016293-pyb00pt5	754	13	of	of	IN
cord-016293-pyb00pt5	754	14	cell	cell	NN
cord-016293-pyb00pt5	754	15	types	type	NNS
cord-016293-pyb00pt5	754	16	will	will	MD
cord-016293-pyb00pt5	754	17	enable	enable	VB
cord-016293-pyb00pt5	754	18	scientists	scientist	NNS
cord-016293-pyb00pt5	754	19	to	to	TO
cord-016293-pyb00pt5	754	20	better	better	RB
cord-016293-pyb00pt5	754	21	understand	understand	VB
cord-016293-pyb00pt5	754	22	cellular	cellular	JJ
cord-016293-pyb00pt5	754	23	processes	process	NNS
cord-016293-pyb00pt5	754	24	and	and	CC
cord-016293-pyb00pt5	754	25	ways	way	NNS
cord-016293-pyb00pt5	754	26	to	to	TO
cord-016293-pyb00pt5	754	27	repair	repair	VB
cord-016293-pyb00pt5	754	28	cells	cell	NNS
cord-016293-pyb00pt5	754	29	when	when	WRB
cord-016293-pyb00pt5	754	30	they	-PRON-	PRP
cord-016293-pyb00pt5	754	31	malfunction	malfunction	VBP
cord-016293-pyb00pt5	754	32	.	.	.
cord-016293-pyb00pt5	755	1	It	-PRON-	PRP
cord-016293-pyb00pt5	755	2	also	also	RB
cord-016293-pyb00pt5	755	3	holds	hold	VBZ
cord-016293-pyb00pt5	755	4	great	great	JJ
cord-016293-pyb00pt5	755	5	potential	potential	NN
cord-016293-pyb00pt5	755	6	to	to	TO
cord-016293-pyb00pt5	755	7	yield	yield	VB
cord-016293-pyb00pt5	755	8	revolutionary	revolutionary	JJ
cord-016293-pyb00pt5	755	9	treatments	treatment	NNS
cord-016293-pyb00pt5	755	10	by	by	IN
cord-016293-pyb00pt5	755	11	transplanting	transplant	VBG
cord-016293-pyb00pt5	755	12	new	new	JJ
cord-016293-pyb00pt5	755	13	tissue	tissue	NN
cord-016293-pyb00pt5	755	14	to	to	TO
cord-016293-pyb00pt5	755	15	treat	treat	VB
cord-016293-pyb00pt5	755	16	heart	heart	NN
cord-016293-pyb00pt5	755	17	disease	disease	NN
cord-016293-pyb00pt5	755	18	,	,	,
cord-016293-pyb00pt5	755	19	atherosclerosis	atherosclerosis	NN
cord-016293-pyb00pt5	755	20	,	,	,
cord-016293-pyb00pt5	755	21	blood	blood	NN
cord-016293-pyb00pt5	755	22	disorders	disorder	NNS
cord-016293-pyb00pt5	755	23	,	,	,
cord-016293-pyb00pt5	755	24	diabetes	diabetes	NN
cord-016293-pyb00pt5	755	25	,	,	,
cord-016293-pyb00pt5	755	26	Parkinson	Parkinson	NNP
cord-016293-pyb00pt5	755	27	's	's	POS
cord-016293-pyb00pt5	755	28	,	,	,
cord-016293-pyb00pt5	755	29	Alzheimer	Alzheimer	NNP
cord-016293-pyb00pt5	755	30	's	's	POS
cord-016293-pyb00pt5	755	31	,	,	,
cord-016293-pyb00pt5	755	32	stroke	stroke	NN
cord-016293-pyb00pt5	755	33	,	,	,
cord-016293-pyb00pt5	755	34	spinal	spinal	JJ
cord-016293-pyb00pt5	755	35	cord	cord	NN
cord-016293-pyb00pt5	755	36	injuries	injury	NNS
cord-016293-pyb00pt5	755	37	,	,	,
cord-016293-pyb00pt5	755	38	rheumatoid	rheumatoid	JJ
cord-016293-pyb00pt5	755	39	arthritis	arthritis	NN
cord-016293-pyb00pt5	755	40	,	,	,
cord-016293-pyb00pt5	755	41	and	and	CC
cord-016293-pyb00pt5	755	42	many	many	JJ
cord-016293-pyb00pt5	755	43	other	other	JJ
cord-016293-pyb00pt5	755	44	diseases	disease	NNS
cord-016293-pyb00pt5	755	45	.	.	.
cord-016293-pyb00pt5	756	1	By	by	IN
cord-016293-pyb00pt5	756	2	using	use	VBG
cord-016293-pyb00pt5	756	3	stem	stem	NN
cord-016293-pyb00pt5	756	4	cells	cell	NNS
cord-016293-pyb00pt5	756	5	,	,	,
cord-016293-pyb00pt5	756	6	scientists	scientist	NNS
cord-016293-pyb00pt5	756	7	may	may	MD
cord-016293-pyb00pt5	756	8	be	be	VB
cord-016293-pyb00pt5	756	9	able	able	JJ
cord-016293-pyb00pt5	756	10	to	to	TO
cord-016293-pyb00pt5	756	11	grow	grow	VB
cord-016293-pyb00pt5	756	12	human	human	JJ
cord-016293-pyb00pt5	756	13	skin	skin	NN
cord-016293-pyb00pt5	756	14	cells	cell	NNS
cord-016293-pyb00pt5	756	15	to	to	TO
cord-016293-pyb00pt5	756	16	treat	treat	VB
cord-016293-pyb00pt5	756	17	wounds	wound	NNS
cord-016293-pyb00pt5	756	18	and	and	CC
cord-016293-pyb00pt5	756	19	burns	burn	NNS
cord-016293-pyb00pt5	756	20	.	.	.
cord-016293-pyb00pt5	757	1	And	and	CC
cord-016293-pyb00pt5	757	2	,	,	,
cord-016293-pyb00pt5	757	3	it	-PRON-	PRP
cord-016293-pyb00pt5	757	4	will	will	MD
cord-016293-pyb00pt5	757	5	aid	aid	VB
cord-016293-pyb00pt5	757	6	the	the	DT
cord-016293-pyb00pt5	757	7	understanding	understanding	NN
cord-016293-pyb00pt5	757	8	of	of	IN
cord-016293-pyb00pt5	757	9	fertility	fertility	NN
cord-016293-pyb00pt5	757	10	disorders	disorder	NNS
cord-016293-pyb00pt5	757	11	.	.	.
cord-016293-pyb00pt5	758	1	Many	many	JJ
cord-016293-pyb00pt5	758	2	patient	patient	JJ
cord-016293-pyb00pt5	758	3	and	and	CC
cord-016293-pyb00pt5	758	4	scientific	scientific	JJ
cord-016293-pyb00pt5	758	5	organizations	organization	NNS
cord-016293-pyb00pt5	758	6	recognize	recognize	VBP
cord-016293-pyb00pt5	758	7	the	the	DT
cord-016293-pyb00pt5	758	8	vast	vast	JJ
cord-016293-pyb00pt5	758	9	potential	potential	NN
cord-016293-pyb00pt5	758	10	of	of	IN
cord-016293-pyb00pt5	758	11	stem	stem	NN
cord-016293-pyb00pt5	758	12	cell	cell	NN
cord-016293-pyb00pt5	758	13	research	research	NN
cord-016293-pyb00pt5	758	14	.	.	.
cord-016293-pyb00pt5	759	1	Another	another	DT
cord-016293-pyb00pt5	759	2	possible	possible	JJ
cord-016293-pyb00pt5	759	3	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	759	4	technique	technique	NN
cord-016293-pyb00pt5	759	5	is	be	VBZ
cord-016293-pyb00pt5	759	6	the	the	DT
cord-016293-pyb00pt5	759	7	generation	generation	NN
cord-016293-pyb00pt5	759	8	of	of	IN
cord-016293-pyb00pt5	759	9	"	"	``
cord-016293-pyb00pt5	759	10	customized	customized	JJ
cord-016293-pyb00pt5	759	11	"	"	''
cord-016293-pyb00pt5	759	12	stem	stem	NN
cord-016293-pyb00pt5	759	13	cells	cell	NNS
cord-016293-pyb00pt5	759	14	.	.	.
cord-016293-pyb00pt5	760	1	A	a	DT
cord-016293-pyb00pt5	760	2	researcher	researcher	NN
cord-016293-pyb00pt5	760	3	or	or	CC
cord-016293-pyb00pt5	760	4	doctor	doctor	NN
cord-016293-pyb00pt5	760	5	might	may	MD
cord-016293-pyb00pt5	760	6	need	need	VB
cord-016293-pyb00pt5	760	7	to	to	TO
cord-016293-pyb00pt5	760	8	develop	develop	VB
cord-016293-pyb00pt5	760	9	a	a	DT
cord-016293-pyb00pt5	760	10	special	special	JJ
cord-016293-pyb00pt5	760	11	cell	cell	NN
cord-016293-pyb00pt5	760	12	line	line	NN
cord-016293-pyb00pt5	760	13	that	that	WDT
cord-016293-pyb00pt5	760	14	contains	contain	VBZ
cord-016293-pyb00pt5	760	15	the	the	DT
cord-016293-pyb00pt5	760	16	DNA	dna	NN
cord-016293-pyb00pt5	760	17	of	of	IN
cord-016293-pyb00pt5	760	18	a	a	DT
cord-016293-pyb00pt5	760	19	person	person	NN
cord-016293-pyb00pt5	760	20	living	live	VBG
cord-016293-pyb00pt5	760	21	with	with	IN
cord-016293-pyb00pt5	760	22	a	a	DT
cord-016293-pyb00pt5	760	23	disease	disease	NN
cord-016293-pyb00pt5	760	24	.	.	.
cord-016293-pyb00pt5	761	1	By	by	IN
cord-016293-pyb00pt5	761	2	using	use	VBG
cord-016293-pyb00pt5	761	3	a	a	DT
cord-016293-pyb00pt5	761	4	technique	technique	NN
cord-016293-pyb00pt5	761	5	called	call	VBN
cord-016293-pyb00pt5	761	6	"	"	``
cord-016293-pyb00pt5	761	7	somatic	somatic	JJ
cord-016293-pyb00pt5	761	8	cell	cell	NN
cord-016293-pyb00pt5	761	9	nuclear	nuclear	JJ
cord-016293-pyb00pt5	761	10	transfer	transfer	NN
cord-016293-pyb00pt5	761	11	"	"	''
cord-016293-pyb00pt5	761	12	the	the	DT
cord-016293-pyb00pt5	761	13	researcher	researcher	NN
cord-016293-pyb00pt5	761	14	can	can	MD
cord-016293-pyb00pt5	761	15	transfer	transfer	VB
cord-016293-pyb00pt5	761	16	a	a	DT
cord-016293-pyb00pt5	761	17	nucleus	nucleus	NN
cord-016293-pyb00pt5	761	18	from	from	IN
cord-016293-pyb00pt5	761	19	the	the	DT
cord-016293-pyb00pt5	761	20	patient	patient	NN
cord-016293-pyb00pt5	761	21	into	into	IN
cord-016293-pyb00pt5	761	22	an	an	DT
cord-016293-pyb00pt5	761	23	enucleated	enucleated	JJ
cord-016293-pyb00pt5	761	24	human	human	JJ
cord-016293-pyb00pt5	761	25	egg	egg	NN
cord-016293-pyb00pt5	761	26	cell	cell	NN
cord-016293-pyb00pt5	761	27	.	.	.
cord-016293-pyb00pt5	762	1	This	this	DT
cord-016293-pyb00pt5	762	2	reformed	reform	VBN
cord-016293-pyb00pt5	762	3	cell	cell	NN
cord-016293-pyb00pt5	762	4	can	can	MD
cord-016293-pyb00pt5	762	5	then	then	RB
cord-016293-pyb00pt5	762	6	be	be	VB
cord-016293-pyb00pt5	762	7	activated	activate	VBN
cord-016293-pyb00pt5	762	8	to	to	TO
cord-016293-pyb00pt5	762	9	form	form	VB
cord-016293-pyb00pt5	762	10	a	a	DT
cord-016293-pyb00pt5	762	11	blastocyst	blastocyst	NN
cord-016293-pyb00pt5	762	12	from	from	IN
cord-016293-pyb00pt5	762	13	which	which	WDT
cord-016293-pyb00pt5	762	14	customized	customize	VBN
cord-016293-pyb00pt5	762	15	stem	stem	NN
cord-016293-pyb00pt5	762	16	cell	cell	NN
cord-016293-pyb00pt5	762	17	lines	line	NNS
cord-016293-pyb00pt5	762	18	can	can	MD
cord-016293-pyb00pt5	762	19	be	be	VB
cord-016293-pyb00pt5	762	20	derived	derive	VBN
cord-016293-pyb00pt5	762	21	to	to	TO
cord-016293-pyb00pt5	762	22	treat	treat	VB
cord-016293-pyb00pt5	762	23	the	the	DT
cord-016293-pyb00pt5	762	24	individual	individual	NN
cord-016293-pyb00pt5	762	25	from	from	IN
cord-016293-pyb00pt5	762	26	whom	whom	WP
cord-016293-pyb00pt5	762	27	the	the	DT
cord-016293-pyb00pt5	762	28	nucleus	nucleus	NN
cord-016293-pyb00pt5	762	29	was	be	VBD
cord-016293-pyb00pt5	762	30	extracted	extract	VBN
cord-016293-pyb00pt5	762	31	.	.	.
cord-016293-pyb00pt5	763	1	By	by	IN
cord-016293-pyb00pt5	763	2	using	use	VBG
cord-016293-pyb00pt5	763	3	the	the	DT
cord-016293-pyb00pt5	763	4	individual	individual	NN
cord-016293-pyb00pt5	763	5	's	's	POS
cord-016293-pyb00pt5	763	6	own	own	JJ
cord-016293-pyb00pt5	763	7	DNA	dna	NN
cord-016293-pyb00pt5	763	8	,	,	,
cord-016293-pyb00pt5	763	9	the	the	DT
cord-016293-pyb00pt5	763	10	stem	stem	NN
cord-016293-pyb00pt5	763	11	cell	cell	NN
cord-016293-pyb00pt5	763	12	line	line	NN
cord-016293-pyb00pt5	763	13	would	would	MD
cord-016293-pyb00pt5	763	14	be	be	VB
cord-016293-pyb00pt5	763	15	fully	fully	RB
cord-016293-pyb00pt5	763	16	compatible	compatible	JJ
cord-016293-pyb00pt5	763	17	and	and	CC
cord-016293-pyb00pt5	763	18	not	not	RB
cord-016293-pyb00pt5	763	19	be	be	VB
cord-016293-pyb00pt5	763	20	rejected	reject	VBN
cord-016293-pyb00pt5	763	21	by	by	IN
cord-016293-pyb00pt5	763	22	the	the	DT
cord-016293-pyb00pt5	763	23	person	person	NN
cord-016293-pyb00pt5	763	24	when	when	WRB
cord-016293-pyb00pt5	763	25	the	the	DT
cord-016293-pyb00pt5	763	26	stem	stem	NN
cord-016293-pyb00pt5	763	27	cells	cell	NNS
cord-016293-pyb00pt5	763	28	are	be	VBP
cord-016293-pyb00pt5	763	29	transferred	transfer	VBN
cord-016293-pyb00pt5	763	30	back	back	RB
cord-016293-pyb00pt5	763	31	to	to	IN
cord-016293-pyb00pt5	763	32	that	that	DT
cord-016293-pyb00pt5	763	33	person	person	NN
cord-016293-pyb00pt5	763	34	for	for	IN
cord-016293-pyb00pt5	763	35	the	the	DT
cord-016293-pyb00pt5	763	36	treatment	treatment	NN
cord-016293-pyb00pt5	763	37	.	.	.
cord-016293-pyb00pt5	764	1	Preliminary	preliminary	JJ
cord-016293-pyb00pt5	764	2	research	research	NN
cord-016293-pyb00pt5	764	3	is	be	VBZ
cord-016293-pyb00pt5	764	4	occurring	occur	VBG
cord-016293-pyb00pt5	764	5	on	on	IN
cord-016293-pyb00pt5	764	6	other	other	JJ
cord-016293-pyb00pt5	764	7	approaches	approach	NNS
cord-016293-pyb00pt5	764	8	to	to	TO
cord-016293-pyb00pt5	764	9	produce	produce	VB
cord-016293-pyb00pt5	764	10	pluripotent	pluripotent	JJ
cord-016293-pyb00pt5	764	11	human	human	JJ
cord-016293-pyb00pt5	764	12	ES	es	NN
cord-016293-pyb00pt5	764	13	cells	cell	NNS
cord-016293-pyb00pt5	764	14	without	without	IN
cord-016293-pyb00pt5	764	15	the	the	DT
cord-016293-pyb00pt5	764	16	need	need	NN
cord-016293-pyb00pt5	764	17	to	to	TO
cord-016293-pyb00pt5	764	18	use	use	VB
cord-016293-pyb00pt5	764	19	human	human	JJ
cord-016293-pyb00pt5	764	20	oocytes	oocyte	NNS
cord-016293-pyb00pt5	764	21	.	.	.
cord-016293-pyb00pt5	765	1	Human	human	JJ
cord-016293-pyb00pt5	765	2	oocytes	oocyte	NNS
cord-016293-pyb00pt5	765	3	may	may	MD
cord-016293-pyb00pt5	765	4	not	not	RB
cord-016293-pyb00pt5	765	5	be	be	VB
cord-016293-pyb00pt5	765	6	available	available	JJ
cord-016293-pyb00pt5	765	7	in	in	IN
cord-016293-pyb00pt5	765	8	quantities	quantity	NNS
cord-016293-pyb00pt5	765	9	that	that	WDT
cord-016293-pyb00pt5	765	10	would	would	MD
cord-016293-pyb00pt5	765	11	meet	meet	VB
cord-016293-pyb00pt5	765	12	the	the	DT
cord-016293-pyb00pt5	765	13	needs	need	NNS
cord-016293-pyb00pt5	765	14	of	of	IN
cord-016293-pyb00pt5	765	15	millions	million	NNS
cord-016293-pyb00pt5	765	16	of	of	IN
cord-016293-pyb00pt5	765	17	potential	potential	JJ
cord-016293-pyb00pt5	765	18	patients	patient	NNS
cord-016293-pyb00pt5	765	19	.	.	.
cord-016293-pyb00pt5	766	1	However	however	RB
cord-016293-pyb00pt5	766	2	,	,	,
cord-016293-pyb00pt5	766	3	no	no	DT
cord-016293-pyb00pt5	766	4	peer	peer	NN
cord-016293-pyb00pt5	766	5	-	-	HYPH
cord-016293-pyb00pt5	766	6	reviewed	review	VBN
cord-016293-pyb00pt5	766	7	papers	paper	NNS
cord-016293-pyb00pt5	766	8	have	have	VBP
cord-016293-pyb00pt5	766	9	yet	yet	RB
cord-016293-pyb00pt5	766	10	appeared	appear	VBN
cord-016293-pyb00pt5	766	11	from	from	IN
cord-016293-pyb00pt5	766	12	which	which	WDT
cord-016293-pyb00pt5	766	13	to	to	TO
cord-016293-pyb00pt5	766	14	judge	judge	VB
cord-016293-pyb00pt5	766	15	whether	whether	IN
cord-016293-pyb00pt5	766	16	animal	animal	NN
cord-016293-pyb00pt5	766	17	oocytes	oocyte	NNS
cord-016293-pyb00pt5	766	18	could	could	MD
cord-016293-pyb00pt5	766	19	be	be	VB
cord-016293-pyb00pt5	766	20	used	use	VBN
cord-016293-pyb00pt5	766	21	to	to	TO
cord-016293-pyb00pt5	766	22	manufacture	manufacture	VB
cord-016293-pyb00pt5	766	23	"	"	``
cord-016293-pyb00pt5	766	24	customized	customized	JJ
cord-016293-pyb00pt5	766	25	"	"	''
cord-016293-pyb00pt5	766	26	human	human	JJ
cord-016293-pyb00pt5	766	27	ES	ES	NNP
cord-016293-pyb00pt5	766	28	cells	cell	NNS
cord-016293-pyb00pt5	766	29	and	and	CC
cord-016293-pyb00pt5	766	30	whether	whether	IN
cord-016293-pyb00pt5	766	31	they	-PRON-	PRP
cord-016293-pyb00pt5	766	32	can	can	MD
cord-016293-pyb00pt5	766	33	be	be	VB
cord-016293-pyb00pt5	766	34	developed	develop	VBN
cord-016293-pyb00pt5	766	35	on	on	IN
cord-016293-pyb00pt5	766	36	a	a	DT
cord-016293-pyb00pt5	766	37	realistic	realistic	JJ
cord-016293-pyb00pt5	766	38	timescale	timescale	NN
cord-016293-pyb00pt5	766	39	.	.	.
cord-016293-pyb00pt5	767	1	Additional	additional	JJ
cord-016293-pyb00pt5	767	2	approaches	approach	NNS
cord-016293-pyb00pt5	767	3	under	under	IN
cord-016293-pyb00pt5	767	4	consideration	consideration	NN
cord-016293-pyb00pt5	767	5	include	include	VBP
cord-016293-pyb00pt5	767	6	early	early	JJ
cord-016293-pyb00pt5	767	7	experimental	experimental	JJ
cord-016293-pyb00pt5	767	8	studies	study	NNS
cord-016293-pyb00pt5	767	9	on	on	IN
cord-016293-pyb00pt5	767	10	the	the	DT
cord-016293-pyb00pt5	767	11	use	use	NN
cord-016293-pyb00pt5	767	12	of	of	IN
cord-016293-pyb00pt5	767	13	cytoplasmic	cytoplasmic	JJ
cord-016293-pyb00pt5	767	14	-	-	HYPH
cord-016293-pyb00pt5	767	15	like	like	JJ
cord-016293-pyb00pt5	767	16	media	medium	NNS
cord-016293-pyb00pt5	767	17	that	that	WDT
cord-016293-pyb00pt5	767	18	might	may	MD
cord-016293-pyb00pt5	767	19	allow	allow	VB
cord-016293-pyb00pt5	767	20	a	a	DT
cord-016293-pyb00pt5	767	21	viable	viable	JJ
cord-016293-pyb00pt5	767	22	approach	approach	NN
cord-016293-pyb00pt5	767	23	in	in	IN
cord-016293-pyb00pt5	767	24	laboratory	laboratory	NN
cord-016293-pyb00pt5	767	25	cultures	culture	NNS
cord-016293-pyb00pt5	767	26	.	.	.
cord-016293-pyb00pt5	768	1	On	on	IN
cord-016293-pyb00pt5	768	2	a	a	DT
cord-016293-pyb00pt5	768	3	much	much	RB
cord-016293-pyb00pt5	768	4	longer	long	JJR
cord-016293-pyb00pt5	768	5	timeline	timeline	NN
cord-016293-pyb00pt5	768	6	,	,	,
cord-016293-pyb00pt5	768	7	it	-PRON-	PRP
cord-016293-pyb00pt5	768	8	may	may	MD
cord-016293-pyb00pt5	768	9	be	be	VB
cord-016293-pyb00pt5	768	10	possible	possible	JJ
cord-016293-pyb00pt5	768	11	to	to	TO
cord-016293-pyb00pt5	768	12	use	use	VB
cord-016293-pyb00pt5	768	13	sophisticated	sophisticated	JJ
cord-016293-pyb00pt5	768	14	genetic	genetic	JJ
cord-016293-pyb00pt5	768	15	modification	modification	NN
cord-016293-pyb00pt5	768	16	techniques	technique	NNS
cord-016293-pyb00pt5	768	17	to	to	TO
cord-016293-pyb00pt5	768	18	eliminate	eliminate	VB
cord-016293-pyb00pt5	768	19	the	the	DT
cord-016293-pyb00pt5	768	20	major	major	JJ
cord-016293-pyb00pt5	768	21	histocompatibility	histocompatibility	NN
cord-016293-pyb00pt5	768	22	complexes	complex	NNS
cord-016293-pyb00pt5	768	23	and	and	CC
cord-016293-pyb00pt5	768	24	other	other	JJ
cord-016293-pyb00pt5	768	25	cell	cell	NN
cord-016293-pyb00pt5	768	26	-	-	HYPH
cord-016293-pyb00pt5	768	27	surface	surface	NN
cord-016293-pyb00pt5	768	28	antigens	antigen	NNS
cord-016293-pyb00pt5	768	29	from	from	IN
cord-016293-pyb00pt5	768	30	foreign	foreign	JJ
cord-016293-pyb00pt5	768	31	cells	cell	NNS
cord-016293-pyb00pt5	768	32	to	to	TO
cord-016293-pyb00pt5	768	33	prepare	prepare	VB
cord-016293-pyb00pt5	768	34	master	master	NN
cord-016293-pyb00pt5	768	35	stem	stem	NN
cord-016293-pyb00pt5	768	36	cell	cell	NN
cord-016293-pyb00pt5	768	37	lines	line	NNS
cord-016293-pyb00pt5	768	38	with	with	IN
cord-016293-pyb00pt5	768	39	less	less	JJR
cord-016293-pyb00pt5	768	40	likelihood	likelihood	NN
cord-016293-pyb00pt5	768	41	of	of	IN
cord-016293-pyb00pt5	768	42	rejection	rejection	NN
cord-016293-pyb00pt5	768	43	.	.	.
cord-016293-pyb00pt5	769	1	This	this	DT
cord-016293-pyb00pt5	769	2	could	could	MD
cord-016293-pyb00pt5	769	3	lead	lead	VB
cord-016293-pyb00pt5	769	4	to	to	IN
cord-016293-pyb00pt5	769	5	the	the	DT
cord-016293-pyb00pt5	769	6	development	development	NN
cord-016293-pyb00pt5	769	7	of	of	IN
cord-016293-pyb00pt5	769	8	a	a	DT
cord-016293-pyb00pt5	769	9	bank	bank	NN
cord-016293-pyb00pt5	769	10	of	of	IN
cord-016293-pyb00pt5	769	11	universal	universal	JJ
cord-016293-pyb00pt5	769	12	donor	donor	NN
cord-016293-pyb00pt5	769	13	cells	cell	NNS
cord-016293-pyb00pt5	769	14	or	or	CC
cord-016293-pyb00pt5	769	15	multiple	multiple	JJ
cord-016293-pyb00pt5	769	16	types	type	NNS
cord-016293-pyb00pt5	769	17	of	of	IN
cord-016293-pyb00pt5	769	18	compatible	compatible	JJ
cord-016293-pyb00pt5	769	19	donor	donor	NN
cord-016293-pyb00pt5	769	20	cells	cell	NNS
cord-016293-pyb00pt5	769	21	of	of	IN
cord-016293-pyb00pt5	769	22	invaluable	invaluable	JJ
cord-016293-pyb00pt5	769	23	benefit	benefit	NN
cord-016293-pyb00pt5	769	24	to	to	TO
cord-016293-pyb00pt5	769	25	treat	treat	VB
cord-016293-pyb00pt5	769	26	all	all	DT
cord-016293-pyb00pt5	769	27	patients	patient	NNS
cord-016293-pyb00pt5	769	28	.	.	.
cord-016293-pyb00pt5	770	1	However	however	RB
cord-016293-pyb00pt5	770	2	,	,	,
cord-016293-pyb00pt5	770	3	the	the	DT
cord-016293-pyb00pt5	770	4	human	human	JJ
cord-016293-pyb00pt5	770	5	immune	immune	NN
cord-016293-pyb00pt5	770	6	system	system	NN
cord-016293-pyb00pt5	770	7	is	be	VBZ
cord-016293-pyb00pt5	770	8	sensitive	sensitive	JJ
cord-016293-pyb00pt5	770	9	to	to	IN
cord-016293-pyb00pt5	770	10	many	many	JJ
cord-016293-pyb00pt5	770	11	minor	minor	JJ
cord-016293-pyb00pt5	770	12	histocompatibility	histocompatibility	NN
cord-016293-pyb00pt5	770	13	complexes	complex	NNS
cord-016293-pyb00pt5	770	14	and	and	CC
cord-016293-pyb00pt5	770	15	immunosuppressive	immunosuppressive	JJ
cord-016293-pyb00pt5	770	16	therapy	therapy	NN
cord-016293-pyb00pt5	770	17	carries	carry	VBZ
cord-016293-pyb00pt5	770	18	life	life	NN
cord-016293-pyb00pt5	770	19	-	-	HYPH
cord-016293-pyb00pt5	770	20	threatening	threaten	VBG
cord-016293-pyb00pt5	770	21	complications	complication	NNS
cord-016293-pyb00pt5	770	22	.	.	.
cord-016293-pyb00pt5	771	1	Stem	stem	NN
cord-016293-pyb00pt5	771	2	cells	cell	NNS
cord-016293-pyb00pt5	771	3	also	also	RB
cord-016293-pyb00pt5	771	4	show	show	VBP
cord-016293-pyb00pt5	771	5	great	great	JJ
cord-016293-pyb00pt5	771	6	potential	potential	NN
cord-016293-pyb00pt5	771	7	to	to	TO
cord-016293-pyb00pt5	771	8	aid	aid	VB
cord-016293-pyb00pt5	771	9	research	research	NN
cord-016293-pyb00pt5	771	10	and	and	CC
cord-016293-pyb00pt5	771	11	development	development	NN
cord-016293-pyb00pt5	771	12	of	of	IN
cord-016293-pyb00pt5	771	13	new	new	JJ
cord-016293-pyb00pt5	771	14	drugs	drug	NNS
cord-016293-pyb00pt5	771	15	and	and	CC
cord-016293-pyb00pt5	771	16	biologics	biologic	NNS
cord-016293-pyb00pt5	771	17	.	.	.
cord-016293-pyb00pt5	772	1	Now	now	RB
cord-016293-pyb00pt5	772	2	,	,	,
cord-016293-pyb00pt5	772	3	stem	stem	NN
cord-016293-pyb00pt5	772	4	cells	cell	NNS
cord-016293-pyb00pt5	772	5	can	can	MD
cord-016293-pyb00pt5	772	6	serve	serve	VB
cord-016293-pyb00pt5	772	7	as	as	IN
cord-016293-pyb00pt5	772	8	a	a	DT
cord-016293-pyb00pt5	772	9	source	source	NN
cord-016293-pyb00pt5	772	10	for	for	IN
cord-016293-pyb00pt5	772	11	normal	normal	JJ
cord-016293-pyb00pt5	772	12	human	human	JJ
cord-016293-pyb00pt5	772	13	differentiated	differentiated	JJ
cord-016293-pyb00pt5	772	14	cells	cell	NNS
cord-016293-pyb00pt5	772	15	to	to	TO
cord-016293-pyb00pt5	772	16	be	be	VB
cord-016293-pyb00pt5	772	17	used	use	VBN
cord-016293-pyb00pt5	772	18	for	for	IN
cord-016293-pyb00pt5	772	19	drug	drug	NN
cord-016293-pyb00pt5	772	20	screening	screening	NN
cord-016293-pyb00pt5	772	21	and	and	CC
cord-016293-pyb00pt5	772	22	testing	testing	NN
cord-016293-pyb00pt5	772	23	,	,	,
cord-016293-pyb00pt5	772	24	drug	drug	NN
cord-016293-pyb00pt5	772	25	toxicology	toxicology	NN
cord-016293-pyb00pt5	772	26	studies	study	NNS
cord-016293-pyb00pt5	772	27	and	and	CC
cord-016293-pyb00pt5	772	28	to	to	TO
cord-016293-pyb00pt5	772	29	identify	identify	VB
cord-016293-pyb00pt5	772	30	new	new	JJ
cord-016293-pyb00pt5	772	31	drug	drug	NN
cord-016293-pyb00pt5	772	32	targets	target	NNS
cord-016293-pyb00pt5	772	33	.	.	.
cord-016293-pyb00pt5	773	1	The	the	DT
cord-016293-pyb00pt5	773	2	ability	ability	NN
cord-016293-pyb00pt5	773	3	to	to	TO
cord-016293-pyb00pt5	773	4	evaluate	evaluate	VB
cord-016293-pyb00pt5	773	5	drug	drug	NN
cord-016293-pyb00pt5	773	6	toxicity	toxicity	NN
cord-016293-pyb00pt5	773	7	in	in	IN
cord-016293-pyb00pt5	773	8	human	human	JJ
cord-016293-pyb00pt5	773	9	cell	cell	NN
cord-016293-pyb00pt5	773	10	lines	line	NNS
cord-016293-pyb00pt5	773	11	grown	grow	VBN
cord-016293-pyb00pt5	773	12	from	from	IN
cord-016293-pyb00pt5	773	13	stem	stem	NN
cord-016293-pyb00pt5	773	14	cells	cell	NNS
cord-016293-pyb00pt5	773	15	could	could	MD
cord-016293-pyb00pt5	773	16	significantly	significantly	RB
cord-016293-pyb00pt5	773	17	reduce	reduce	VB
cord-016293-pyb00pt5	773	18	the	the	DT
cord-016293-pyb00pt5	773	19	need	need	NN
cord-016293-pyb00pt5	773	20	to	to	TO
cord-016293-pyb00pt5	773	21	test	test	VB
cord-016293-pyb00pt5	773	22	a	a	DT
cord-016293-pyb00pt5	773	23	drug	drug	NN
cord-016293-pyb00pt5	773	24	's	's	POS
cord-016293-pyb00pt5	773	25	safety	safety	NN
cord-016293-pyb00pt5	773	26	in	in	IN
cord-016293-pyb00pt5	773	27	animal	animal	NN
cord-016293-pyb00pt5	773	28	models	model	NNS
cord-016293-pyb00pt5	773	29	.	.	.
cord-016293-pyb00pt5	774	1	There	there	EX
cord-016293-pyb00pt5	774	2	are	be	VBP
cord-016293-pyb00pt5	774	3	other	other	JJ
cord-016293-pyb00pt5	774	4	sources	source	NNS
cord-016293-pyb00pt5	774	5	of	of	IN
cord-016293-pyb00pt5	774	6	stem	stem	NN
cord-016293-pyb00pt5	774	7	cells	cell	NNS
cord-016293-pyb00pt5	774	8	,	,	,
cord-016293-pyb00pt5	774	9	including	include	VBG
cord-016293-pyb00pt5	774	10	stem	stem	NN
cord-016293-pyb00pt5	774	11	cells	cell	NNS
cord-016293-pyb00pt5	774	12	that	that	WDT
cord-016293-pyb00pt5	774	13	are	be	VBP
cord-016293-pyb00pt5	774	14	found	find	VBN
cord-016293-pyb00pt5	774	15	in	in	IN
cord-016293-pyb00pt5	774	16	blood	blood	NN
cord-016293-pyb00pt5	774	17	.	.	.
cord-016293-pyb00pt5	775	1	Recent	recent	JJ
cord-016293-pyb00pt5	775	2	reports	report	NNS
cord-016293-pyb00pt5	775	3	note	note	VBP
cord-016293-pyb00pt5	775	4	the	the	DT
cord-016293-pyb00pt5	775	5	possible	possible	JJ
cord-016293-pyb00pt5	775	6	isolation	isolation	NN
cord-016293-pyb00pt5	775	7	of	of	IN
cord-016293-pyb00pt5	775	8	stem	stem	NN
cord-016293-pyb00pt5	775	9	cells	cell	NNS
cord-016293-pyb00pt5	775	10	for	for	IN
cord-016293-pyb00pt5	775	11	the	the	DT
cord-016293-pyb00pt5	775	12	brain	brain	NN
cord-016293-pyb00pt5	775	13	from	from	IN
cord-016293-pyb00pt5	775	14	the	the	DT
cord-016293-pyb00pt5	775	15	lining	lining	NN
cord-016293-pyb00pt5	775	16	of	of	IN
cord-016293-pyb00pt5	775	17	the	the	DT
cord-016293-pyb00pt5	775	18	spinal	spinal	JJ
cord-016293-pyb00pt5	775	19	cord	cord	NN
cord-016293-pyb00pt5	775	20	.	.	.
cord-016293-pyb00pt5	776	1	Other	other	JJ
cord-016293-pyb00pt5	776	2	reports	report	NNS
cord-016293-pyb00pt5	776	3	indicate	indicate	VBP
cord-016293-pyb00pt5	776	4	that	that	IN
cord-016293-pyb00pt5	776	5	some	some	DT
cord-016293-pyb00pt5	776	6	stem	stem	NN
cord-016293-pyb00pt5	776	7	cells	cell	NNS
cord-016293-pyb00pt5	776	8	that	that	WDT
cord-016293-pyb00pt5	776	9	were	be	VBD
cord-016293-pyb00pt5	776	10	thought	think	VBN
cord-016293-pyb00pt5	776	11	to	to	TO
cord-016293-pyb00pt5	776	12	have	have	VB
cord-016293-pyb00pt5	776	13	differentiated	differentiate	VBN
cord-016293-pyb00pt5	776	14	into	into	IN
cord-016293-pyb00pt5	776	15	one	one	CD
cord-016293-pyb00pt5	776	16	type	type	NN
cord-016293-pyb00pt5	776	17	of	of	IN
cord-016293-pyb00pt5	776	18	cell	cell	NN
cord-016293-pyb00pt5	776	19	can	can	MD
cord-016293-pyb00pt5	776	20	also	also	RB
cord-016293-pyb00pt5	776	21	become	become	VB
cord-016293-pyb00pt5	776	22	other	other	JJ
cord-016293-pyb00pt5	776	23	types	type	NNS
cord-016293-pyb00pt5	776	24	of	of	IN
cord-016293-pyb00pt5	776	25	cells	cell	NNS
cord-016293-pyb00pt5	776	26	,	,	,
cord-016293-pyb00pt5	776	27	in	in	IN
cord-016293-pyb00pt5	776	28	particular	particular	JJ
cord-016293-pyb00pt5	776	29	brain	brain	NN
cord-016293-pyb00pt5	776	30	stem	stem	NN
cord-016293-pyb00pt5	776	31	cells	cell	NNS
cord-016293-pyb00pt5	776	32	with	with	IN
cord-016293-pyb00pt5	776	33	the	the	DT
cord-016293-pyb00pt5	776	34	potential	potential	NN
cord-016293-pyb00pt5	776	35	to	to	TO
cord-016293-pyb00pt5	776	36	become	become	VB
cord-016293-pyb00pt5	776	37	blood	blood	NN
cord-016293-pyb00pt5	776	38	cells	cell	NNS
cord-016293-pyb00pt5	776	39	.	.	.
cord-016293-pyb00pt5	777	1	However	however	RB
cord-016293-pyb00pt5	777	2	,	,	,
cord-016293-pyb00pt5	777	3	since	since	IN
cord-016293-pyb00pt5	777	4	these	these	DT
cord-016293-pyb00pt5	777	5	reports	report	NNS
cord-016293-pyb00pt5	777	6	reflect	reflect	VBP
cord-016293-pyb00pt5	777	7	very	very	RB
cord-016293-pyb00pt5	777	8	early	early	JJ
cord-016293-pyb00pt5	777	9	cellular	cellular	JJ
cord-016293-pyb00pt5	777	10	research	research	NN
cord-016293-pyb00pt5	777	11	about	about	IN
cord-016293-pyb00pt5	777	12	which	which	WDT
cord-016293-pyb00pt5	777	13	little	little	JJ
cord-016293-pyb00pt5	777	14	is	be	VBZ
cord-016293-pyb00pt5	777	15	known	know	VBN
cord-016293-pyb00pt5	777	16	,	,	,
cord-016293-pyb00pt5	777	17	we	-PRON-	PRP
cord-016293-pyb00pt5	777	18	should	should	MD
cord-016293-pyb00pt5	777	19	continue	continue	VB
cord-016293-pyb00pt5	777	20	to	to	TO
cord-016293-pyb00pt5	777	21	pursue	pursue	VB
cord-016293-pyb00pt5	777	22	basic	basic	JJ
cord-016293-pyb00pt5	777	23	research	research	NN
cord-016293-pyb00pt5	777	24	on	on	IN
cord-016293-pyb00pt5	777	25	all	all	DT
cord-016293-pyb00pt5	777	26	types	type	NNS
cord-016293-pyb00pt5	777	27	of	of	IN
cord-016293-pyb00pt5	777	28	stem	stem	NN
cord-016293-pyb00pt5	777	29	cells	cell	NNS
cord-016293-pyb00pt5	777	30	.	.	.
cord-016293-pyb00pt5	778	1	Some	some	DT
cord-016293-pyb00pt5	778	2	religious	religious	JJ
cord-016293-pyb00pt5	778	3	leaders	leader	NNS
cord-016293-pyb00pt5	778	4	will	will	MD
cord-016293-pyb00pt5	778	5	advocate	advocate	VB
cord-016293-pyb00pt5	778	6	that	that	IN
cord-016293-pyb00pt5	778	7	researchers	researcher	NNS
cord-016293-pyb00pt5	778	8	should	should	MD
cord-016293-pyb00pt5	778	9	only	only	RB
cord-016293-pyb00pt5	778	10	use	use	VB
cord-016293-pyb00pt5	778	11	certain	certain	JJ
cord-016293-pyb00pt5	778	12	types	type	NNS
cord-016293-pyb00pt5	778	13	of	of	IN
cord-016293-pyb00pt5	778	14	stem	stem	NN
cord-016293-pyb00pt5	778	15	cells	cell	NNS
cord-016293-pyb00pt5	778	16	.	.	.
cord-016293-pyb00pt5	779	1	However	however	RB
cord-016293-pyb00pt5	779	2	,	,	,
cord-016293-pyb00pt5	779	3	because	because	IN
cord-016293-pyb00pt5	779	4	human	human	JJ
cord-016293-pyb00pt5	779	5	embryonic	embryonic	JJ
cord-016293-pyb00pt5	779	6	stem	stem	NN
cord-016293-pyb00pt5	779	7	cells	cell	NNS
cord-016293-pyb00pt5	779	8	hold	hold	VBP
cord-016293-pyb00pt5	779	9	the	the	DT
cord-016293-pyb00pt5	779	10	potential	potential	NN
cord-016293-pyb00pt5	779	11	to	to	TO
cord-016293-pyb00pt5	779	12	differentiate	differentiate	VB
cord-016293-pyb00pt5	779	13	into	into	IN
cord-016293-pyb00pt5	779	14	any	any	DT
cord-016293-pyb00pt5	779	15	type	type	NN
cord-016293-pyb00pt5	779	16	of	of	IN
cord-016293-pyb00pt5	779	17	cell	cell	NN
cord-016293-pyb00pt5	779	18	in	in	IN
cord-016293-pyb00pt5	779	19	the	the	DT
cord-016293-pyb00pt5	779	20	human	human	JJ
cord-016293-pyb00pt5	779	21	body	body	NN
cord-016293-pyb00pt5	779	22	,	,	,
cord-016293-pyb00pt5	779	23	no	no	DT
cord-016293-pyb00pt5	779	24	avenue	avenue	NN
cord-016293-pyb00pt5	779	25	of	of	IN
cord-016293-pyb00pt5	779	26	research	research	NN
cord-016293-pyb00pt5	779	27	should	should	MD
cord-016293-pyb00pt5	779	28	be	be	VB
cord-016293-pyb00pt5	779	29	foreclosed	foreclose	VBN
cord-016293-pyb00pt5	779	30	.	.	.
cord-016293-pyb00pt5	780	1	Rather	rather	RB
cord-016293-pyb00pt5	780	2	,	,	,
cord-016293-pyb00pt5	780	3	we	-PRON-	PRP
cord-016293-pyb00pt5	780	4	must	must	MD
cord-016293-pyb00pt5	780	5	find	find	VB
cord-016293-pyb00pt5	780	6	ways	way	NNS
cord-016293-pyb00pt5	780	7	to	to	TO
cord-016293-pyb00pt5	780	8	facilitate	facilitate	VB
cord-016293-pyb00pt5	780	9	the	the	DT
cord-016293-pyb00pt5	780	10	pursuit	pursuit	NN
cord-016293-pyb00pt5	780	11	of	of	IN
cord-016293-pyb00pt5	780	12	all	all	DT
cord-016293-pyb00pt5	780	13	research	research	NN
cord-016293-pyb00pt5	780	14	using	use	VBG
cord-016293-pyb00pt5	780	15	stem	stem	NN
cord-016293-pyb00pt5	780	16	cells	cell	NNS
cord-016293-pyb00pt5	780	17	while	while	IN
cord-016293-pyb00pt5	780	18	addressing	address	VBG
cord-016293-pyb00pt5	780	19	the	the	DT
cord-016293-pyb00pt5	780	20	ethical	ethical	JJ
cord-016293-pyb00pt5	780	21	concerns	concern	NNS
cord-016293-pyb00pt5	780	22	that	that	WDT
cord-016293-pyb00pt5	780	23	may	may	MD
cord-016293-pyb00pt5	780	24	be	be	VB
cord-016293-pyb00pt5	780	25	raised	raise	VBN
cord-016293-pyb00pt5	780	26	.	.	.
cord-016293-pyb00pt5	781	1	Another	another	DT
cord-016293-pyb00pt5	781	2	seminal	seminal	JJ
cord-016293-pyb00pt5	781	3	and	and	CC
cord-016293-pyb00pt5	781	4	intimately	intimately	RB
cord-016293-pyb00pt5	781	5	related	related	JJ
cord-016293-pyb00pt5	781	6	event	event	NN
cord-016293-pyb00pt5	781	7	at	at	IN
cord-016293-pyb00pt5	781	8	the	the	DT
cord-016293-pyb00pt5	781	9	end	end	NN
cord-016293-pyb00pt5	781	10	of	of	IN
cord-016293-pyb00pt5	781	11	the	the	DT
cord-016293-pyb00pt5	781	12	nineties	ninety	NNS
cord-016293-pyb00pt5	781	13	occurred	occur	VBD
cord-016293-pyb00pt5	781	14	in	in	IN
cord-016293-pyb00pt5	781	15	Madison	Madison	NNP
cord-016293-pyb00pt5	781	16	Wisconsin	Wisconsin	NNP
cord-016293-pyb00pt5	781	17	.	.	.
cord-016293-pyb00pt5	782	1	Up	up	IN
cord-016293-pyb00pt5	782	2	until	until	IN
cord-016293-pyb00pt5	782	3	November	November	NNP
cord-016293-pyb00pt5	782	4	of	of	IN
cord-016293-pyb00pt5	782	5	1998	1998	CD
cord-016293-pyb00pt5	782	6	,	,	,
cord-016293-pyb00pt5	782	7	isolating	isolate	VBG
cord-016293-pyb00pt5	782	8	ES	ES	NNP
cord-016293-pyb00pt5	782	9	cells	cell	NNS
cord-016293-pyb00pt5	782	10	in	in	IN
cord-016293-pyb00pt5	782	11	mammals	mammal	NNS
cord-016293-pyb00pt5	782	12	other	other	JJ
cord-016293-pyb00pt5	782	13	than	than	IN
cord-016293-pyb00pt5	782	14	mice	mouse	NNS
cord-016293-pyb00pt5	782	15	proved	prove	VBD
cord-016293-pyb00pt5	782	16	elusive	elusive	JJ
cord-016293-pyb00pt5	782	17	,	,	,
cord-016293-pyb00pt5	782	18	but	but	CC
cord-016293-pyb00pt5	782	19	in	in	IN
cord-016293-pyb00pt5	782	20	a	a	DT
cord-016293-pyb00pt5	782	21	milestone	milestone	NN
cord-016293-pyb00pt5	782	22	paper	paper	NN
cord-016293-pyb00pt5	782	23	in	in	IN
cord-016293-pyb00pt5	782	24	the	the	DT
cord-016293-pyb00pt5	782	25	November	November	NNP
cord-016293-pyb00pt5	782	26	5	5	CD
cord-016293-pyb00pt5	782	27	,	,	,
cord-016293-pyb00pt5	782	28	1998	1998	CD
cord-016293-pyb00pt5	782	29	issue	issue	NN
cord-016293-pyb00pt5	782	30	of	of	IN
cord-016293-pyb00pt5	782	31	Science	Science	NNP
cord-016293-pyb00pt5	782	32	,	,	,
cord-016293-pyb00pt5	782	33	James	James	NNP
cord-016293-pyb00pt5	782	34	A.	A.	NNP
cord-016293-pyb00pt5	782	35	Thomson	Thomson	NNP
cord-016293-pyb00pt5	782	36	,	,	,
cord-016293-pyb00pt5	782	37	(	(	-LRB-
cord-016293-pyb00pt5	782	38	1998	1998	CD
cord-016293-pyb00pt5	782	39	)	)	-RRB-
cord-016293-pyb00pt5	782	40	a	a	DT
cord-016293-pyb00pt5	782	41	developmental	developmental	JJ
cord-016293-pyb00pt5	782	42	biologist	biologist	NN
cord-016293-pyb00pt5	782	43	at	at	IN
cord-016293-pyb00pt5	782	44	UW	UW	NNP
cord-016293-pyb00pt5	782	45	-	-	HYPH
cord-016293-pyb00pt5	782	46	Madison	Madison	NNP
cord-016293-pyb00pt5	782	47	reported	report	VBD
cord-016293-pyb00pt5	782	48	the	the	DT
cord-016293-pyb00pt5	782	49	first	first	JJ
cord-016293-pyb00pt5	782	50	successful	successful	JJ
cord-016293-pyb00pt5	782	51	isolation	isolation	NN
cord-016293-pyb00pt5	782	52	,	,	,
cord-016293-pyb00pt5	782	53	derivation	derivation	NN
cord-016293-pyb00pt5	782	54	and	and	CC
cord-016293-pyb00pt5	782	55	maintenance	maintenance	NN
cord-016293-pyb00pt5	782	56	of	of	IN
cord-016293-pyb00pt5	782	57	a	a	DT
cord-016293-pyb00pt5	782	58	culture	culture	NN
cord-016293-pyb00pt5	782	59	of	of	IN
cord-016293-pyb00pt5	782	60	human	human	JJ
cord-016293-pyb00pt5	782	61	embryonic	embryonic	JJ
cord-016293-pyb00pt5	782	62	stem	stem	NN
cord-016293-pyb00pt5	782	63	cells	cell	NNS
cord-016293-pyb00pt5	782	64	(	(	-LRB-
cord-016293-pyb00pt5	782	65	hES	hes	NN
cord-016293-pyb00pt5	782	66	cells	cell	NNS
cord-016293-pyb00pt5	782	67	)	)	-RRB-
cord-016293-pyb00pt5	782	68	.	.	.
cord-016293-pyb00pt5	783	1	It	-PRON-	PRP
cord-016293-pyb00pt5	783	2	is	be	VBZ
cord-016293-pyb00pt5	783	3	interesting	interesting	JJ
cord-016293-pyb00pt5	783	4	to	to	TO
cord-016293-pyb00pt5	783	5	note	note	VB
cord-016293-pyb00pt5	783	6	that	that	IN
cord-016293-pyb00pt5	783	7	this	this	DT
cord-016293-pyb00pt5	783	8	leap	leap	NN
cord-016293-pyb00pt5	783	9	was	be	VBD
cord-016293-pyb00pt5	783	10	made	make	VBN
cord-016293-pyb00pt5	783	11	from	from	IN
cord-016293-pyb00pt5	783	12	mouse	mouse	NN
cord-016293-pyb00pt5	783	13	to	to	IN
cord-016293-pyb00pt5	783	14	man	man	NN
cord-016293-pyb00pt5	783	15	.	.	.
cord-016293-pyb00pt5	784	1	As	as	IN
cord-016293-pyb00pt5	784	2	Thomson	Thomson	NNP
cord-016293-pyb00pt5	784	3	himself	-PRON-	PRP
cord-016293-pyb00pt5	784	4	put	put	VBD
cord-016293-pyb00pt5	784	5	it	-PRON-	PRP
cord-016293-pyb00pt5	784	6	,	,	,
cord-016293-pyb00pt5	784	7	these	these	DT
cord-016293-pyb00pt5	784	8	cells	cell	NNS
cord-016293-pyb00pt5	784	9	are	be	VBP
cord-016293-pyb00pt5	784	10	different	different	JJ
cord-016293-pyb00pt5	784	11	from	from	IN
cord-016293-pyb00pt5	784	12	all	all	DT
cord-016293-pyb00pt5	784	13	other	other	JJ
cord-016293-pyb00pt5	784	14	human	human	JJ
cord-016293-pyb00pt5	784	15	stem	stem	NN
cord-016293-pyb00pt5	784	16	cells	cell	NNS
cord-016293-pyb00pt5	784	17	isolated	isolate	VBN
cord-016293-pyb00pt5	784	18	to	to	IN
cord-016293-pyb00pt5	784	19	date	date	NN
cord-016293-pyb00pt5	784	20	and	and	CC
cord-016293-pyb00pt5	784	21	as	as	IN
cord-016293-pyb00pt5	784	22	the	the	DT
cord-016293-pyb00pt5	784	23	source	source	NN
cord-016293-pyb00pt5	784	24	of	of	IN
cord-016293-pyb00pt5	784	25	all	all	DT
cord-016293-pyb00pt5	784	26	cell	cell	NN
cord-016293-pyb00pt5	784	27	types	type	NNS
cord-016293-pyb00pt5	784	28	,	,	,
cord-016293-pyb00pt5	784	29	they	-PRON-	PRP
cord-016293-pyb00pt5	784	30	hold	hold	VBP
cord-016293-pyb00pt5	784	31	great	great	JJ
cord-016293-pyb00pt5	784	32	promise	promise	NN
cord-016293-pyb00pt5	784	33	for	for	IN
cord-016293-pyb00pt5	784	34	use	use	NN
cord-016293-pyb00pt5	784	35	in	in	IN
cord-016293-pyb00pt5	784	36	transplantation	transplantation	NN
cord-016293-pyb00pt5	784	37	medicine	medicine	NN
cord-016293-pyb00pt5	784	38	,	,	,
cord-016293-pyb00pt5	784	39	drug	drug	NN
cord-016293-pyb00pt5	784	40	discovery	discovery	NN
cord-016293-pyb00pt5	784	41	and	and	CC
cord-016293-pyb00pt5	784	42	development	development	NN
cord-016293-pyb00pt5	784	43	,	,	,
cord-016293-pyb00pt5	784	44	and	and	CC
cord-016293-pyb00pt5	784	45	the	the	DT
cord-016293-pyb00pt5	784	46	study	study	NN
cord-016293-pyb00pt5	784	47	of	of	IN
cord-016293-pyb00pt5	784	48	human	human	JJ
cord-016293-pyb00pt5	784	49	developmental	developmental	JJ
cord-016293-pyb00pt5	784	50	biology	biology	NN
cord-016293-pyb00pt5	784	51	.	.	.
cord-016293-pyb00pt5	785	1	The	the	DT
cord-016293-pyb00pt5	785	2	new	new	JJ
cord-016293-pyb00pt5	785	3	century	century	NN
cord-016293-pyb00pt5	785	4	is	be	VBZ
cord-016293-pyb00pt5	785	5	rapidly	rapidly	RB
cord-016293-pyb00pt5	785	6	exploiting	exploit	VBG
cord-016293-pyb00pt5	785	7	this	this	DT
cord-016293-pyb00pt5	785	8	vision	vision	NN
cord-016293-pyb00pt5	785	9	.	.	.
cord-016293-pyb00pt5	786	1	When	when	WRB
cord-016293-pyb00pt5	786	2	Steve	Steve	NNP
cord-016293-pyb00pt5	786	3	Fodor	Fodor	NNP
cord-016293-pyb00pt5	786	4	was	be	VBD
cord-016293-pyb00pt5	786	5	asked	ask	VBN
cord-016293-pyb00pt5	786	6	in	in	IN
cord-016293-pyb00pt5	786	7	2003	2003	CD
cord-016293-pyb00pt5	786	8	"	"	``
cord-016293-pyb00pt5	786	9	How	how	WRB
cord-016293-pyb00pt5	786	10	do	do	VBP
cord-016293-pyb00pt5	786	11	you	-PRON-	PRP
cord-016293-pyb00pt5	786	12	really	really	RB
cord-016293-pyb00pt5	786	13	take	take	VB
cord-016293-pyb00pt5	786	14	the	the	DT
cord-016293-pyb00pt5	786	15	Human	Human	NNP
cord-016293-pyb00pt5	786	16	genome	genome	NN
cord-016293-pyb00pt5	786	17	sequence	sequence	NN
cord-016293-pyb00pt5	786	18	and	and	CC
cord-016293-pyb00pt5	786	19	transform	transform	VB
cord-016293-pyb00pt5	786	20	it	-PRON-	PRP
cord-016293-pyb00pt5	786	21	into	into	IN
cord-016293-pyb00pt5	786	22	knowledge	knowledge	NN
cord-016293-pyb00pt5	786	23	?	?	.
cord-016293-pyb00pt5	786	24	"	"	''
cord-016293-pyb00pt5	787	1	he	-PRON-	PRP
cord-016293-pyb00pt5	787	2	answered	answer	VBD
cord-016293-pyb00pt5	787	3	from	from	IN
cord-016293-pyb00pt5	787	4	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	787	5	's	's	POS
cord-016293-pyb00pt5	787	6	perspective	perspective	NN
cord-016293-pyb00pt5	787	7	,	,	,
cord-016293-pyb00pt5	787	8	it	-PRON-	PRP
cord-016293-pyb00pt5	787	9	is	be	VBZ
cord-016293-pyb00pt5	787	10	a	a	DT
cord-016293-pyb00pt5	787	11	technology	technology	NN
cord-016293-pyb00pt5	787	12	development	development	NN
cord-016293-pyb00pt5	787	13	task	task	NN
cord-016293-pyb00pt5	787	14	.	.	.
cord-016293-pyb00pt5	788	1	He	-PRON-	PRP
cord-016293-pyb00pt5	788	2	sees	see	VBZ
cord-016293-pyb00pt5	788	3	the	the	DT
cord-016293-pyb00pt5	788	4	colloquially	colloquially	RB
cord-016293-pyb00pt5	788	5	named	name	VBN
cord-016293-pyb00pt5	788	6	affychips	affychip	NNS
cord-016293-pyb00pt5	788	7	being	be	VBG
cord-016293-pyb00pt5	788	8	the	the	DT
cord-016293-pyb00pt5	788	9	equivalent	equivalent	NN
cord-016293-pyb00pt5	788	10	of	of	IN
cord-016293-pyb00pt5	788	11	a	a	DT
cord-016293-pyb00pt5	788	12	CD	cd	NN
cord-016293-pyb00pt5	788	13	-	-	HYPH
cord-016293-pyb00pt5	788	14	ROM	rom	NN
cord-016293-pyb00pt5	788	15	of	of	IN
cord-016293-pyb00pt5	788	16	the	the	DT
cord-016293-pyb00pt5	788	17	genome	genome	NN
cord-016293-pyb00pt5	788	18	.	.	.
cord-016293-pyb00pt5	789	1	They	-PRON-	PRP
cord-016293-pyb00pt5	789	2	take	take	VBP
cord-016293-pyb00pt5	789	3	information	information	NN
cord-016293-pyb00pt5	789	4	from	from	IN
cord-016293-pyb00pt5	789	5	the	the	DT
cord-016293-pyb00pt5	789	6	genome	genome	NN
cord-016293-pyb00pt5	789	7	and	and	CC
cord-016293-pyb00pt5	789	8	write	write	VB
cord-016293-pyb00pt5	789	9	it	-PRON-	PRP
cord-016293-pyb00pt5	789	10	down	down	RP
cord-016293-pyb00pt5	789	11	.	.	.
cord-016293-pyb00pt5	790	1	The	the	DT
cord-016293-pyb00pt5	790	2	company	company	NN
cord-016293-pyb00pt5	790	3	has	have	VBZ
cord-016293-pyb00pt5	790	4	come	come	VBN
cord-016293-pyb00pt5	790	5	a	a	DT
cord-016293-pyb00pt5	790	6	long	long	JJ
cord-016293-pyb00pt5	790	7	way	way	NN
cord-016293-pyb00pt5	790	8	from	from	IN
cord-016293-pyb00pt5	790	9	the	the	DT
cord-016293-pyb00pt5	790	10	early	early	JJ
cord-016293-pyb00pt5	790	11	days	day	NNS
cord-016293-pyb00pt5	790	12	of	of	IN
cord-016293-pyb00pt5	790	13	Venter	Venter	NNP
cord-016293-pyb00pt5	790	14	's	's	POS
cord-016293-pyb00pt5	790	15	ESTs	est	NNS
cord-016293-pyb00pt5	790	16	and	and	CC
cord-016293-pyb00pt5	790	17	less	less	JJR
cord-016293-pyb00pt5	790	18	than	than	IN
cord-016293-pyb00pt5	790	19	robust	robust	JJ
cord-016293-pyb00pt5	790	20	algorithms	algorithm	NNS
cord-016293-pyb00pt5	790	21	as	as	IN
cord-016293-pyb00pt5	790	22	described	describe	VBN
cord-016293-pyb00pt5	790	23	earlier	early	RBR
cord-016293-pyb00pt5	790	24	.	.	.
cord-016293-pyb00pt5	791	1	One	one	CD
cord-016293-pyb00pt5	791	2	surprising	surprising	JJ
cord-016293-pyb00pt5	791	3	fact	fact	NN
cord-016293-pyb00pt5	791	4	unearthed	unearth	VBN
cord-016293-pyb00pt5	791	5	by	by	IN
cord-016293-pyb00pt5	791	6	the	the	DT
cord-016293-pyb00pt5	791	7	newer	newer	RBR
cord-016293-pyb00pt5	791	8	more	more	RBR
cord-016293-pyb00pt5	791	9	sophisticated	sophisticated	JJ
cord-016293-pyb00pt5	791	10	generation	generation	NN
cord-016293-pyb00pt5	791	11	of	of	IN
cord-016293-pyb00pt5	791	12	chips	chip	NNS
cord-016293-pyb00pt5	791	13	is	be	VBZ
cord-016293-pyb00pt5	791	14	that	that	IN
cord-016293-pyb00pt5	791	15	30	30	CD
cord-016293-pyb00pt5	791	16	to	to	TO
cord-016293-pyb00pt5	791	17	35	35	CD
cord-016293-pyb00pt5	791	18	percent	percent	NN
cord-016293-pyb00pt5	791	19	of	of	IN
cord-016293-pyb00pt5	791	20	the	the	DT
cord-016293-pyb00pt5	791	21	non	non	JJ
cord-016293-pyb00pt5	791	22	-	-	JJ
cord-016293-pyb00pt5	791	23	repetitive	repetitive	JJ
cord-016293-pyb00pt5	791	24	DNA	dna	NN
cord-016293-pyb00pt5	791	25	is	be	VBZ
cord-016293-pyb00pt5	791	26	being	be	VBG
cord-016293-pyb00pt5	791	27	expressed	express	VBN
cord-016293-pyb00pt5	791	28	as	as	IN
cord-016293-pyb00pt5	791	29	accepted	accept	VBN
cord-016293-pyb00pt5	791	30	knowledge	knowledge	NN
cord-016293-pyb00pt5	791	31	was	be	VBD
cord-016293-pyb00pt5	791	32	that	that	IN
cord-016293-pyb00pt5	791	33	only	only	RB
cord-016293-pyb00pt5	791	34	1.5	1.5	CD
cord-016293-pyb00pt5	791	35	to	to	TO
cord-016293-pyb00pt5	791	36	2	2	CD
cord-016293-pyb00pt5	791	37	percent	percent	NN
cord-016293-pyb00pt5	791	38	of	of	IN
cord-016293-pyb00pt5	791	39	the	the	DT
cord-016293-pyb00pt5	791	40	genome	genome	NN
cord-016293-pyb00pt5	791	41	would	would	MD
cord-016293-pyb00pt5	791	42	be	be	VB
cord-016293-pyb00pt5	791	43	expressed	express	VBN
cord-016293-pyb00pt5	791	44	.	.	.
cord-016293-pyb00pt5	792	1	Since	since	IN
cord-016293-pyb00pt5	792	2	much	much	JJ
cord-016293-pyb00pt5	792	3	of	of	IN
cord-016293-pyb00pt5	792	4	that	that	DT
cord-016293-pyb00pt5	792	5	sequence	sequence	NN
cord-016293-pyb00pt5	792	6	has	have	VBZ
cord-016293-pyb00pt5	792	7	no	no	DT
cord-016293-pyb00pt5	792	8	protein	protein	NN
cord-016293-pyb00pt5	792	9	-	-	HYPH
cord-016293-pyb00pt5	792	10	coding	code	VBG
cord-016293-pyb00pt5	792	11	capacity	capacity	NN
cord-016293-pyb00pt5	793	1	it	-PRON-	PRP
cord-016293-pyb00pt5	793	2	is	be	VBZ
cord-016293-pyb00pt5	793	3	most	most	RBS
cord-016293-pyb00pt5	793	4	likely	likely	RB
cord-016293-pyb00pt5	793	5	coding	code	VBG
cord-016293-pyb00pt5	793	6	for	for	IN
cord-016293-pyb00pt5	793	7	regulatory	regulatory	JJ
cord-016293-pyb00pt5	793	8	functions	function	NNS
cord-016293-pyb00pt5	793	9	.	.	.
cord-016293-pyb00pt5	794	1	In	in	IN
cord-016293-pyb00pt5	794	2	a	a	DT
cord-016293-pyb00pt5	794	3	parallel	parallel	NN
cord-016293-pyb00pt5	794	4	to	to	IN
cord-016293-pyb00pt5	794	5	astrophysics	astrophysic	NNS
cord-016293-pyb00pt5	794	6	this	this	DT
cord-016293-pyb00pt5	794	7	is	be	VBZ
cord-016293-pyb00pt5	794	8	often	often	RB
cord-016293-pyb00pt5	794	9	referred	refer	VBN
cord-016293-pyb00pt5	794	10	to	to	IN
cord-016293-pyb00pt5	794	11	in	in	IN
cord-016293-pyb00pt5	794	12	common	common	JJ
cord-016293-pyb00pt5	794	13	parlance	parlance	NN
cord-016293-pyb00pt5	794	14	as	as	IN
cord-016293-pyb00pt5	794	15	the	the	DT
cord-016293-pyb00pt5	794	16	"	"	``
cord-016293-pyb00pt5	794	17	dark	dark	JJ
cord-016293-pyb00pt5	794	18	matter	matter	NN
cord-016293-pyb00pt5	794	19	of	of	IN
cord-016293-pyb00pt5	794	20	the	the	DT
cord-016293-pyb00pt5	794	21	genome	genome	NN
cord-016293-pyb00pt5	794	22	"	"	''
cord-016293-pyb00pt5	794	23	and	and	CC
cord-016293-pyb00pt5	794	24	like	like	IN
cord-016293-pyb00pt5	794	25	dark	dark	JJ
cord-016293-pyb00pt5	794	26	matter	matter	NN
cord-016293-pyb00pt5	794	27	for	for	IN
cord-016293-pyb00pt5	794	28	many	many	JJ
cord-016293-pyb00pt5	794	29	it	-PRON-	PRP
cord-016293-pyb00pt5	794	30	is	be	VBZ
cord-016293-pyb00pt5	794	31	the	the	DT
cord-016293-pyb00pt5	794	32	most	most	RBS
cord-016293-pyb00pt5	794	33	exciting	exciting	JJ
cord-016293-pyb00pt5	794	34	and	and	CC
cord-016293-pyb00pt5	794	35	challenging	challenging	JJ
cord-016293-pyb00pt5	794	36	aspect	aspect	NN
cord-016293-pyb00pt5	794	37	of	of	IN
cord-016293-pyb00pt5	794	38	uncovering	uncover	VBG
cord-016293-pyb00pt5	794	39	the	the	DT
cord-016293-pyb00pt5	794	40	occult	occult	JJ
cord-016293-pyb00pt5	794	41	genome	genome	NN
cord-016293-pyb00pt5	794	42	.	.	.
cord-016293-pyb00pt5	795	1	It	-PRON-	PRP
cord-016293-pyb00pt5	795	2	could	could	MD
cord-016293-pyb00pt5	795	3	be	be	VB
cord-016293-pyb00pt5	795	4	,	,	,
cord-016293-pyb00pt5	795	5	and	and	CC
cord-016293-pyb00pt5	795	6	most	most	RBS
cord-016293-pyb00pt5	795	7	probably	probably	RB
cord-016293-pyb00pt5	795	8	is	be	VBZ
cord-016293-pyb00pt5	795	9	,	,	,
cord-016293-pyb00pt5	795	10	involved	involve	VBN
cord-016293-pyb00pt5	795	11	in	in	IN
cord-016293-pyb00pt5	795	12	regulatory	regulatory	JJ
cord-016293-pyb00pt5	795	13	functions	function	NNS
cord-016293-pyb00pt5	795	14	,	,	,
cord-016293-pyb00pt5	795	15	networks	network	NNS
cord-016293-pyb00pt5	795	16	,	,	,
cord-016293-pyb00pt5	795	17	or	or	CC
cord-016293-pyb00pt5	795	18	development	development	NN
cord-016293-pyb00pt5	795	19	.	.	.
cord-016293-pyb00pt5	796	1	And	and	CC
cord-016293-pyb00pt5	796	2	like	like	IN
cord-016293-pyb00pt5	796	3	physical	physical	JJ
cord-016293-pyb00pt5	796	4	dark	dark	NN
cord-016293-pyb00pt5	796	5	matter	matter	NN
cord-016293-pyb00pt5	796	6	it	-PRON-	PRP
cord-016293-pyb00pt5	796	7	may	may	MD
cord-016293-pyb00pt5	796	8	change	change	VB
cord-016293-pyb00pt5	796	9	our	-PRON-	PRP$
cord-016293-pyb00pt5	796	10	whole	whole	JJ
cord-016293-pyb00pt5	796	11	concept	concept	NN
cord-016293-pyb00pt5	796	12	of	of	IN
cord-016293-pyb00pt5	796	13	what	what	WP
cord-016293-pyb00pt5	796	14	exactly	exactly	RB
cord-016293-pyb00pt5	796	15	a	a	DT
cord-016293-pyb00pt5	796	16	gene	gene	NN
cord-016293-pyb00pt5	796	17	is	be	VBZ
cord-016293-pyb00pt5	796	18	or	or	CC
cord-016293-pyb00pt5	796	19	is	be	VBZ
cord-016293-pyb00pt5	796	20	not	not	RB
cord-016293-pyb00pt5	796	21	!	!	.
cord-016293-pyb00pt5	797	1	Since	since	IN
cord-016293-pyb00pt5	797	2	Beadle	Beadle	NNP
cord-016293-pyb00pt5	797	3	and	and	CC
cord-016293-pyb00pt5	797	4	Tatum	Tatum	NNP
cord-016293-pyb00pt5	797	5	's	's	POS
cord-016293-pyb00pt5	797	6	circumspect	circumspect	JJ
cord-016293-pyb00pt5	797	7	view	view	NN
cord-016293-pyb00pt5	797	8	of	of	IN
cord-016293-pyb00pt5	797	9	the	the	DT
cord-016293-pyb00pt5	797	10	protein	protein	NN
cord-016293-pyb00pt5	797	11	world	world	NN
cord-016293-pyb00pt5	797	12	no	no	RB
cord-016293-pyb00pt5	797	13	longer	long	RBR
cord-016293-pyb00pt5	797	14	holds	hold	VBZ
cord-016293-pyb00pt5	797	15	true	true	JJ
cord-016293-pyb00pt5	797	16	it	-PRON-	PRP
cord-016293-pyb00pt5	797	17	adds	add	VBZ
cord-016293-pyb00pt5	797	18	a	a	DT
cord-016293-pyb00pt5	797	19	layer	layer	NN
cord-016293-pyb00pt5	797	20	of	of	IN
cord-016293-pyb00pt5	797	21	complexity	complexity	NN
cord-016293-pyb00pt5	797	22	to	to	IN
cord-016293-pyb00pt5	797	23	organizing	organize	VBG
cord-016293-pyb00pt5	797	24	chip	chip	NN
cord-016293-pyb00pt5	797	25	design	design	NN
cord-016293-pyb00pt5	797	26	.	.	.
cord-016293-pyb00pt5	798	1	Depending	depend	VBG
cord-016293-pyb00pt5	798	2	on	on	IN
cord-016293-pyb00pt5	798	3	which	which	WDT
cord-016293-pyb00pt5	798	4	sequences	sequence	NNS
cord-016293-pyb00pt5	798	5	are	be	VBP
cord-016293-pyb00pt5	798	6	present	present	JJ
cord-016293-pyb00pt5	798	7	in	in	IN
cord-016293-pyb00pt5	798	8	a	a	DT
cord-016293-pyb00pt5	798	9	particular	particular	JJ
cord-016293-pyb00pt5	798	10	transcript	transcript	NN
cord-016293-pyb00pt5	798	11	,	,	,
cord-016293-pyb00pt5	798	12	you	-PRON-	PRP
cord-016293-pyb00pt5	798	13	can	can	MD
cord-016293-pyb00pt5	798	14	,	,	,
cord-016293-pyb00pt5	798	15	theoretically	theoretically	RB
cord-016293-pyb00pt5	798	16	,	,	,
cord-016293-pyb00pt5	798	17	design	design	VB
cord-016293-pyb00pt5	798	18	a	a	DT
cord-016293-pyb00pt5	798	19	set	set	NN
cord-016293-pyb00pt5	798	20	of	of	IN
cord-016293-pyb00pt5	798	21	probes	probe	NNS
cord-016293-pyb00pt5	798	22	to	to	TO
cord-016293-pyb00pt5	798	23	uniquely	uniquely	RB
cord-016293-pyb00pt5	798	24	distinguish	distinguish	VB
cord-016293-pyb00pt5	798	25	that	that	DT
cord-016293-pyb00pt5	798	26	variant	variant	NN
cord-016293-pyb00pt5	798	27	.	.	.
cord-016293-pyb00pt5	799	1	At	at	IN
cord-016293-pyb00pt5	799	2	the	the	DT
cord-016293-pyb00pt5	799	3	DNA	dna	NN
cord-016293-pyb00pt5	799	4	level	level	NN
cord-016293-pyb00pt5	799	5	itself	-PRON-	PRP
cord-016293-pyb00pt5	799	6	there	there	EX
cord-016293-pyb00pt5	799	7	is	be	VBZ
cord-016293-pyb00pt5	799	8	much	much	JJ
cord-016293-pyb00pt5	799	9	potential	potential	NN
cord-016293-pyb00pt5	799	10	for	for	IN
cord-016293-pyb00pt5	799	11	looking	look	VBG
cord-016293-pyb00pt5	799	12	at	at	IN
cord-016293-pyb00pt5	799	13	variants	variant	NNS
cord-016293-pyb00pt5	799	14	either	either	CC
cord-016293-pyb00pt5	799	15	expressed	express	VBD
cord-016293-pyb00pt5	799	16	or	or	CC
cord-016293-pyb00pt5	799	17	not	not	RB
cord-016293-pyb00pt5	799	18	at	at	IN
cord-016293-pyb00pt5	799	19	a	a	DT
cord-016293-pyb00pt5	799	20	very	very	RB
cord-016293-pyb00pt5	799	21	basic	basic	JJ
cord-016293-pyb00pt5	799	22	level	level	NN
cord-016293-pyb00pt5	799	23	as	as	IN
cord-016293-pyb00pt5	799	24	a	a	DT
cord-016293-pyb00pt5	799	25	diagnostic	diagnostic	JJ
cord-016293-pyb00pt5	799	26	system	system	NN
cord-016293-pyb00pt5	799	27	,	,	,
cord-016293-pyb00pt5	799	28	but	but	CC
cord-016293-pyb00pt5	799	29	ultimately	ultimately	RB
cord-016293-pyb00pt5	799	30	the	the	DT
cord-016293-pyb00pt5	799	31	real	real	JJ
cord-016293-pyb00pt5	799	32	paydirt	paydirt	NN
cord-016293-pyb00pt5	799	33	is	be	VBZ
cord-016293-pyb00pt5	799	34	the	the	DT
cord-016293-pyb00pt5	799	35	information	information	NN
cord-016293-pyb00pt5	799	36	that	that	WDT
cord-016293-pyb00pt5	799	37	can	can	MD
cord-016293-pyb00pt5	799	38	be	be	VB
cord-016293-pyb00pt5	799	39	gained	gain	VBN
cord-016293-pyb00pt5	799	40	from	from	IN
cord-016293-pyb00pt5	799	41	looking	look	VBG
cord-016293-pyb00pt5	799	42	at	at	IN
cord-016293-pyb00pt5	799	43	the	the	DT
cord-016293-pyb00pt5	799	44	consequence	consequence	NN
cord-016293-pyb00pt5	799	45	of	of	IN
cord-016293-pyb00pt5	799	46	non	non	JJ
cord-016293-pyb00pt5	799	47	-	-	JJ
cord-016293-pyb00pt5	799	48	coding	coding	JJ
cord-016293-pyb00pt5	799	49	sequence	sequence	NN
cord-016293-pyb00pt5	799	50	variation	variation	NN
cord-016293-pyb00pt5	799	51	on	on	IN
cord-016293-pyb00pt5	799	52	the	the	DT
cord-016293-pyb00pt5	799	53	transcriptome	transcriptome	NN
cord-016293-pyb00pt5	799	54	itself	-PRON-	PRP
cord-016293-pyb00pt5	799	55	.	.	.
cord-016293-pyb00pt5	800	1	And	and	CC
cord-016293-pyb00pt5	800	2	fine	fine	JJ
cord-016293-pyb00pt5	800	3	tuning	tuning	NN
cord-016293-pyb00pt5	800	4	when	when	WRB
cord-016293-pyb00pt5	800	5	this	this	DT
cord-016293-pyb00pt5	800	6	matters	matter	VBZ
cord-016293-pyb00pt5	800	7	and	and	CC
cord-016293-pyb00pt5	800	8	when	when	WRB
cord-016293-pyb00pt5	800	9	it	-PRON-	PRP
cord-016293-pyb00pt5	800	10	is	be	VBZ
cord-016293-pyb00pt5	800	11	irrelevant	irrelevant	JJ
cord-016293-pyb00pt5	800	12	as	as	IN
cord-016293-pyb00pt5	800	13	a	a	DT
cord-016293-pyb00pt5	800	14	predicative	predicative	JJ
cord-016293-pyb00pt5	800	15	model	model	NN
cord-016293-pyb00pt5	800	16	is	be	VBZ
cord-016293-pyb00pt5	800	17	the	the	DT
cord-016293-pyb00pt5	800	18	auspices	auspex	NNS
cord-016293-pyb00pt5	800	19	of	of	IN
cord-016293-pyb00pt5	800	20	the	the	DT
cord-016293-pyb00pt5	800	21	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	800	22	spin	spin	NN
cord-016293-pyb00pt5	800	23	-	-	HYPH
cord-016293-pyb00pt5	800	24	off	off	RP
cord-016293-pyb00pt5	800	25	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	800	26	.	.	.
cord-016293-pyb00pt5	801	1	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	801	2	came	come	VBD
cord-016293-pyb00pt5	801	3	into	into	IN
cord-016293-pyb00pt5	801	4	being	being	NN
cord-016293-pyb00pt5	801	5	in	in	IN
cord-016293-pyb00pt5	801	6	late	late	JJ
cord-016293-pyb00pt5	801	7	2000	2000	CD
cord-016293-pyb00pt5	801	8	to	to	TO
cord-016293-pyb00pt5	801	9	accelerate	accelerate	VB
cord-016293-pyb00pt5	801	10	the	the	DT
cord-016293-pyb00pt5	801	11	development	development	NN
cord-016293-pyb00pt5	801	12	of	of	IN
cord-016293-pyb00pt5	801	13	high	high	JJ
cord-016293-pyb00pt5	801	14	-	-	HYPH
cord-016293-pyb00pt5	801	15	resolution	resolution	NN
cord-016293-pyb00pt5	801	16	,	,	,
cord-016293-pyb00pt5	801	17	whole	whole	JJ
cord-016293-pyb00pt5	801	18	genome	genome	NN
cord-016293-pyb00pt5	801	19	scanning	scanning	NN
cord-016293-pyb00pt5	801	20	.	.	.
cord-016293-pyb00pt5	802	1	And	and	CC
cord-016293-pyb00pt5	802	2	they	-PRON-	PRP
cord-016293-pyb00pt5	802	3	have	have	VBP
cord-016293-pyb00pt5	802	4	stuck	stick	VBN
cord-016293-pyb00pt5	802	5	to	to	IN
cord-016293-pyb00pt5	802	6	that	that	DT
cord-016293-pyb00pt5	802	7	purity	purity	NN
cord-016293-pyb00pt5	802	8	of	of	IN
cord-016293-pyb00pt5	802	9	purpose	purpose	NN
cord-016293-pyb00pt5	802	10	.	.	.
cord-016293-pyb00pt5	803	1	To	to	TO
cord-016293-pyb00pt5	803	2	paraphrase	paraphrase	VB
cord-016293-pyb00pt5	803	3	Dragnet	Dragnet	NNP
cord-016293-pyb00pt5	803	4	's	's	POS
cord-016293-pyb00pt5	803	5	Sergeant	Sergeant	NNP
cord-016293-pyb00pt5	803	6	Joe	Joe	NNP
cord-016293-pyb00pt5	803	7	Friday	Friday	NNP
cord-016293-pyb00pt5	803	8	,	,	,
cord-016293-pyb00pt5	803	9	they	-PRON-	PRP
cord-016293-pyb00pt5	803	10	focus	focus	VBP
cord-016293-pyb00pt5	803	11	on	on	IN
cord-016293-pyb00pt5	803	12	the	the	DT
cord-016293-pyb00pt5	803	13	facts	fact	NNS
cord-016293-pyb00pt5	803	14	of	of	IN
cord-016293-pyb00pt5	803	15	DNA	DNA	NNP
cord-016293-pyb00pt5	803	16	just	just	RB
cord-016293-pyb00pt5	803	17	the	the	DT
cord-016293-pyb00pt5	803	18	DNA	dna	NN
cord-016293-pyb00pt5	803	19	.	.	.
cord-016293-pyb00pt5	804	1	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	804	2	owes	owe	VBZ
cord-016293-pyb00pt5	804	3	its	-PRON-	PRP$
cord-016293-pyb00pt5	804	4	true	true	JJ
cord-016293-pyb00pt5	804	5	genesis	genesis	NN
cord-016293-pyb00pt5	804	6	to	to	IN
cord-016293-pyb00pt5	804	7	the	the	DT
cord-016293-pyb00pt5	804	8	desire	desire	NN
cord-016293-pyb00pt5	804	9	of	of	IN
cord-016293-pyb00pt5	804	10	one	one	CD
cord-016293-pyb00pt5	804	11	of	of	IN
cord-016293-pyb00pt5	804	12	its	-PRON-	PRP$
cord-016293-pyb00pt5	804	13	cofounders	cofounder	NNS
cord-016293-pyb00pt5	804	14	to	to	TO
cord-016293-pyb00pt5	804	15	use	use	VB
cord-016293-pyb00pt5	804	16	DNA	dna	NN
cord-016293-pyb00pt5	804	17	chips	chip	NNS
cord-016293-pyb00pt5	804	18	to	to	TO
cord-016293-pyb00pt5	804	19	help	help	VB
cord-016293-pyb00pt5	804	20	understand	understand	VB
cord-016293-pyb00pt5	804	21	the	the	DT
cord-016293-pyb00pt5	804	22	dynamics	dynamic	NNS
cord-016293-pyb00pt5	804	23	underlying	underlie	VBG
cord-016293-pyb00pt5	804	24	genetic	genetic	JJ
cord-016293-pyb00pt5	804	25	diseases	disease	NNS
cord-016293-pyb00pt5	804	26	.	.	.
cord-016293-pyb00pt5	805	1	Brad	Brad	NNP
cord-016293-pyb00pt5	805	2	Margus	Margus	NNP
cord-016293-pyb00pt5	805	3	'	'	POS
cord-016293-pyb00pt5	805	4	two	two	CD
cord-016293-pyb00pt5	805	5	sons	son	NNS
cord-016293-pyb00pt5	805	6	have	have	VBP
cord-016293-pyb00pt5	805	7	the	the	DT
cord-016293-pyb00pt5	805	8	rare	rare	JJ
cord-016293-pyb00pt5	805	9	disease	disease	NN
cord-016293-pyb00pt5	805	10	"	"	''
cord-016293-pyb00pt5	805	11	ataxia	ataxia	NNP
cord-016293-pyb00pt5	805	12	telangiectasia	telangiectasia	NNP
cord-016293-pyb00pt5	805	13	"	"	''
cord-016293-pyb00pt5	805	14	(	(	-LRB-
cord-016293-pyb00pt5	805	15	A	A	NNP
cord-016293-pyb00pt5	805	16	-	-	HYPH
cord-016293-pyb00pt5	805	17	T	T	NNP
cord-016293-pyb00pt5	805	18	)	)	-RRB-
cord-016293-pyb00pt5	805	19	.	.	.
cord-016293-pyb00pt5	806	1	A	a	LS
cord-016293-pyb00pt5	806	2	-	-	HYPH
cord-016293-pyb00pt5	806	3	T	T	NNP
cord-016293-pyb00pt5	806	4	is	be	VBZ
cord-016293-pyb00pt5	806	5	a	a	DT
cord-016293-pyb00pt5	806	6	progressive	progressive	JJ
cord-016293-pyb00pt5	806	7	,	,	,
cord-016293-pyb00pt5	806	8	neurodegenerative	neurodegenerative	JJ
cord-016293-pyb00pt5	806	9	childhood	childhood	NN
cord-016293-pyb00pt5	806	10	disease	disease	NN
cord-016293-pyb00pt5	806	11	that	that	WDT
cord-016293-pyb00pt5	806	12	affects	affect	VBZ
cord-016293-pyb00pt5	806	13	the	the	DT
cord-016293-pyb00pt5	806	14	brain	brain	NN
cord-016293-pyb00pt5	806	15	and	and	CC
cord-016293-pyb00pt5	806	16	other	other	JJ
cord-016293-pyb00pt5	806	17	body	body	NN
cord-016293-pyb00pt5	806	18	systems	system	NNS
cord-016293-pyb00pt5	806	19	.	.	.
cord-016293-pyb00pt5	807	1	The	the	DT
cord-016293-pyb00pt5	807	2	first	first	JJ
cord-016293-pyb00pt5	807	3	signs	sign	NNS
cord-016293-pyb00pt5	807	4	of	of	IN
cord-016293-pyb00pt5	807	5	the	the	DT
cord-016293-pyb00pt5	807	6	disease	disease	NN
cord-016293-pyb00pt5	807	7	,	,	,
cord-016293-pyb00pt5	807	8	which	which	WDT
cord-016293-pyb00pt5	807	9	include	include	VBP
cord-016293-pyb00pt5	807	10	delayed	delay	VBN
cord-016293-pyb00pt5	807	11	development	development	NN
cord-016293-pyb00pt5	807	12	of	of	IN
cord-016293-pyb00pt5	807	13	motor	motor	NN
cord-016293-pyb00pt5	807	14	skills	skill	NNS
cord-016293-pyb00pt5	807	15	,	,	,
cord-016293-pyb00pt5	807	16	poor	poor	JJ
cord-016293-pyb00pt5	807	17	balance	balance	NN
cord-016293-pyb00pt5	807	18	,	,	,
cord-016293-pyb00pt5	807	19	and	and	CC
cord-016293-pyb00pt5	807	20	slurred	slur	VBD
cord-016293-pyb00pt5	807	21	speech	speech	NN
cord-016293-pyb00pt5	807	22	,	,	,
cord-016293-pyb00pt5	807	23	usually	usually	RB
cord-016293-pyb00pt5	807	24	occur	occur	VBP
cord-016293-pyb00pt5	807	25	during	during	IN
cord-016293-pyb00pt5	807	26	the	the	DT
cord-016293-pyb00pt5	807	27	first	first	JJ
cord-016293-pyb00pt5	807	28	decade	decade	NN
cord-016293-pyb00pt5	807	29	of	of	IN
cord-016293-pyb00pt5	807	30	life	life	NN
cord-016293-pyb00pt5	807	31	.	.	.
cord-016293-pyb00pt5	808	1	Telangiectasias	Telangiectasias	NNP
cord-016293-pyb00pt5	808	2	(	(	-LRB-
cord-016293-pyb00pt5	808	3	tiny	tiny	JJ
cord-016293-pyb00pt5	808	4	,	,	,
cord-016293-pyb00pt5	808	5	red	red	JJ
cord-016293-pyb00pt5	808	6	"	"	``
cord-016293-pyb00pt5	808	7	spider	spider	NN
cord-016293-pyb00pt5	808	8	"	"	''
cord-016293-pyb00pt5	808	9	veins	vein	NNS
cord-016293-pyb00pt5	808	10	)	)	-RRB-
cord-016293-pyb00pt5	808	11	,	,	,
cord-016293-pyb00pt5	808	12	which	which	WDT
cord-016293-pyb00pt5	808	13	appear	appear	VBP
cord-016293-pyb00pt5	808	14	in	in	IN
cord-016293-pyb00pt5	808	15	the	the	DT
cord-016293-pyb00pt5	808	16	corners	corner	NNS
cord-016293-pyb00pt5	808	17	of	of	IN
cord-016293-pyb00pt5	808	18	the	the	DT
cord-016293-pyb00pt5	808	19	eyes	eye	NNS
cord-016293-pyb00pt5	808	20	or	or	CC
cord-016293-pyb00pt5	808	21	on	on	IN
cord-016293-pyb00pt5	808	22	the	the	DT
cord-016293-pyb00pt5	808	23	surface	surface	NN
cord-016293-pyb00pt5	808	24	of	of	IN
cord-016293-pyb00pt5	808	25	the	the	DT
cord-016293-pyb00pt5	808	26	ears	ear	NNS
cord-016293-pyb00pt5	808	27	and	and	CC
cord-016293-pyb00pt5	808	28	cheeks	cheek	NNS
cord-016293-pyb00pt5	808	29	,	,	,
cord-016293-pyb00pt5	808	30	are	be	VBP
cord-016293-pyb00pt5	808	31	characteristic	characteristic	JJ
cord-016293-pyb00pt5	808	32	of	of	IN
cord-016293-pyb00pt5	808	33	the	the	DT
cord-016293-pyb00pt5	808	34	disease	disease	NN
cord-016293-pyb00pt5	808	35	,	,	,
cord-016293-pyb00pt5	808	36	but	but	CC
cord-016293-pyb00pt5	808	37	are	be	VBP
cord-016293-pyb00pt5	808	38	not	not	RB
cord-016293-pyb00pt5	808	39	always	always	RB
cord-016293-pyb00pt5	808	40	present	present	JJ
cord-016293-pyb00pt5	808	41	.	.	.
cord-016293-pyb00pt5	809	1	Many	many	JJ
cord-016293-pyb00pt5	809	2	individuals	individual	NNS
cord-016293-pyb00pt5	809	3	with	with	IN
cord-016293-pyb00pt5	809	4	A	A	NNP
cord-016293-pyb00pt5	809	5	-	-	HYPH
cord-016293-pyb00pt5	809	6	T	t	NN
cord-016293-pyb00pt5	809	7	have	have	VBP
cord-016293-pyb00pt5	809	8	a	a	DT
cord-016293-pyb00pt5	809	9	weakened	weaken	VBN
cord-016293-pyb00pt5	809	10	immune	immune	JJ
cord-016293-pyb00pt5	809	11	system	system	NN
cord-016293-pyb00pt5	809	12	,	,	,
cord-016293-pyb00pt5	809	13	making	make	VBG
cord-016293-pyb00pt5	809	14	them	-PRON-	PRP
cord-016293-pyb00pt5	809	15	susceptible	susceptible	JJ
cord-016293-pyb00pt5	809	16	to	to	IN
cord-016293-pyb00pt5	809	17	recurrent	recurrent	JJ
cord-016293-pyb00pt5	809	18	respiratory	respiratory	JJ
cord-016293-pyb00pt5	809	19	infections	infection	NNS
cord-016293-pyb00pt5	809	20	.	.	.
cord-016293-pyb00pt5	810	1	About	about	RB
cord-016293-pyb00pt5	810	2	20	20	CD
cord-016293-pyb00pt5	810	3	%	%	NN
cord-016293-pyb00pt5	810	4	of	of	IN
cord-016293-pyb00pt5	810	5	those	those	DT
cord-016293-pyb00pt5	810	6	with	with	IN
cord-016293-pyb00pt5	810	7	A	A	NNP
cord-016293-pyb00pt5	810	8	-	-	HYPH
cord-016293-pyb00pt5	810	9	T	t	NN
cord-016293-pyb00pt5	810	10	develop	develop	VB
cord-016293-pyb00pt5	810	11	cancer	cancer	NN
cord-016293-pyb00pt5	810	12	,	,	,
cord-016293-pyb00pt5	810	13	most	most	RBS
cord-016293-pyb00pt5	810	14	frequently	frequently	RB
cord-016293-pyb00pt5	810	15	acute	acute	JJ
cord-016293-pyb00pt5	810	16	lymphocytic	lymphocytic	JJ
cord-016293-pyb00pt5	810	17	leukemia	leukemia	NN
cord-016293-pyb00pt5	810	18	or	or	CC
cord-016293-pyb00pt5	810	19	lymphoma	lymphoma	NN
cord-016293-pyb00pt5	810	20	suggesting	suggest	VBG
cord-016293-pyb00pt5	810	21	that	that	IN
cord-016293-pyb00pt5	810	22	the	the	DT
cord-016293-pyb00pt5	810	23	sentinel	sentinel	JJ
cord-016293-pyb00pt5	810	24	competence	competence	NN
cord-016293-pyb00pt5	810	25	of	of	IN
cord-016293-pyb00pt5	810	26	the	the	DT
cord-016293-pyb00pt5	810	27	immune	immune	JJ
cord-016293-pyb00pt5	810	28	system	system	NN
cord-016293-pyb00pt5	810	29	is	be	VBZ
cord-016293-pyb00pt5	810	30	compromised	compromise	VBN
cord-016293-pyb00pt5	810	31	.	.	.
cord-016293-pyb00pt5	811	1	Having	have	VBG
cord-016293-pyb00pt5	811	2	a	a	DT
cord-016293-pyb00pt5	811	3	focus	focus	NN
cord-016293-pyb00pt5	811	4	so	so	RB
cord-016293-pyb00pt5	811	5	close	close	JJ
cord-016293-pyb00pt5	811	6	to	to	IN
cord-016293-pyb00pt5	811	7	home	home	NN
cord-016293-pyb00pt5	811	8	is	be	VBZ
cord-016293-pyb00pt5	811	9	a	a	DT
cord-016293-pyb00pt5	811	10	powerful	powerful	JJ
cord-016293-pyb00pt5	811	11	driver	driver	NN
cord-016293-pyb00pt5	811	12	for	for	IN
cord-016293-pyb00pt5	811	13	any	any	DT
cord-016293-pyb00pt5	811	14	scientist	scientist	NN
cord-016293-pyb00pt5	811	15	.	.	.
cord-016293-pyb00pt5	812	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	812	2	co	co	NN
cord-016293-pyb00pt5	812	3	-	-	NN
cord-016293-pyb00pt5	812	4	founder	founder	NN
cord-016293-pyb00pt5	812	5	David	David	NNP
cord-016293-pyb00pt5	812	6	Cox	Cox	NNP
cord-016293-pyb00pt5	812	7	is	be	VBZ
cord-016293-pyb00pt5	812	8	a	a	DT
cord-016293-pyb00pt5	812	9	polymath	polymath	NN
cord-016293-pyb00pt5	812	10	pediatrician	pediatrician	NN
cord-016293-pyb00pt5	812	11	whose	whose	WP$
cord-016293-pyb00pt5	812	12	training	training	NN
cord-016293-pyb00pt5	812	13	in	in	IN
cord-016293-pyb00pt5	812	14	the	the	DT
cord-016293-pyb00pt5	812	15	latter	latter	NN
cord-016293-pyb00pt5	812	16	informs	inform	VBZ
cord-016293-pyb00pt5	812	17	his	-PRON-	PRP$
cord-016293-pyb00pt5	812	18	application	application	NN
cord-016293-pyb00pt5	812	19	of	of	IN
cord-016293-pyb00pt5	812	20	the	the	DT
cord-016293-pyb00pt5	812	21	former	former	JJ
cord-016293-pyb00pt5	812	22	in	in	IN
cord-016293-pyb00pt5	812	23	the	the	DT
cord-016293-pyb00pt5	812	24	development	development	NN
cord-016293-pyb00pt5	812	25	of	of	IN
cord-016293-pyb00pt5	812	26	patient	patient	NN
cord-016293-pyb00pt5	812	27	-	-	HYPH
cord-016293-pyb00pt5	812	28	centered	center	VBN
cord-016293-pyb00pt5	812	29	tools	tool	NNS
cord-016293-pyb00pt5	812	30	.	.	.
cord-016293-pyb00pt5	813	1	From	from	IN
cord-016293-pyb00pt5	813	2	that	that	DT
cord-016293-pyb00pt5	813	3	perspective	perspective	NN
cord-016293-pyb00pt5	813	4	,	,	,
cord-016293-pyb00pt5	813	5	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	813	6	's	's	POS
cord-016293-pyb00pt5	813	7	stated	state	VBN
cord-016293-pyb00pt5	813	8	mission	mission	NN
cord-016293-pyb00pt5	813	9	is	be	VBZ
cord-016293-pyb00pt5	813	10	to	to	TO
cord-016293-pyb00pt5	813	11	collaborate	collaborate	VB
cord-016293-pyb00pt5	813	12	with	with	IN
cord-016293-pyb00pt5	813	13	partners	partner	NNS
cord-016293-pyb00pt5	813	14	to	to	TO
cord-016293-pyb00pt5	813	15	rescue	rescue	VB
cord-016293-pyb00pt5	813	16	or	or	CC
cord-016293-pyb00pt5	813	17	improve	improve	VB
cord-016293-pyb00pt5	813	18	drugs	drug	NNS
cord-016293-pyb00pt5	813	19	and	and	CC
cord-016293-pyb00pt5	813	20	to	to	TO
cord-016293-pyb00pt5	813	21	uncover	uncover	VB
cord-016293-pyb00pt5	813	22	the	the	DT
cord-016293-pyb00pt5	813	23	genetic	genetic	JJ
cord-016293-pyb00pt5	813	24	bases	basis	NNS
cord-016293-pyb00pt5	813	25	of	of	IN
cord-016293-pyb00pt5	813	26	diseases	disease	NNS
cord-016293-pyb00pt5	813	27	.	.	.
cord-016293-pyb00pt5	814	1	They	-PRON-	PRP
cord-016293-pyb00pt5	814	2	have	have	VBP
cord-016293-pyb00pt5	814	3	created	create	VBN
cord-016293-pyb00pt5	814	4	a	a	DT
cord-016293-pyb00pt5	814	5	whole	whole	JJ
cord-016293-pyb00pt5	814	6	genome	genome	NN
cord-016293-pyb00pt5	814	7	association	association	NN
cord-016293-pyb00pt5	814	8	approach	approach	NN
cord-016293-pyb00pt5	814	9	that	that	WDT
cord-016293-pyb00pt5	814	10	enables	enable	VBZ
cord-016293-pyb00pt5	814	11	them	-PRON-	PRP
cord-016293-pyb00pt5	814	12	to	to	TO
cord-016293-pyb00pt5	814	13	genotype	genotype	VB
cord-016293-pyb00pt5	814	14	millions	million	NNS
cord-016293-pyb00pt5	814	15	of	of	IN
cord-016293-pyb00pt5	814	16	unique	unique	JJ
cord-016293-pyb00pt5	814	17	SNPs	snp	NNS
cord-016293-pyb00pt5	814	18	in	in	IN
cord-016293-pyb00pt5	814	19	thousands	thousand	NNS
cord-016293-pyb00pt5	814	20	of	of	IN
cord-016293-pyb00pt5	814	21	cases	case	NNS
cord-016293-pyb00pt5	814	22	and	and	CC
cord-016293-pyb00pt5	814	23	controls	control	NNS
cord-016293-pyb00pt5	814	24	in	in	IN
cord-016293-pyb00pt5	814	25	a	a	DT
cord-016293-pyb00pt5	814	26	timeframe	timeframe	NN
cord-016293-pyb00pt5	814	27	of	of	IN
cord-016293-pyb00pt5	814	28	months	month	NNS
cord-016293-pyb00pt5	814	29	rather	rather	RB
cord-016293-pyb00pt5	814	30	than	than	IN
cord-016293-pyb00pt5	814	31	years	year	NNS
cord-016293-pyb00pt5	814	32	.	.	.
cord-016293-pyb00pt5	815	1	As	as	IN
cord-016293-pyb00pt5	815	2	mentioned	mention	VBN
cord-016293-pyb00pt5	815	3	previously	previously	RB
cord-016293-pyb00pt5	815	4	,	,	,
cord-016293-pyb00pt5	815	5	SNP	SNP	NNP
cord-016293-pyb00pt5	815	6	(	(	-LRB-
cord-016293-pyb00pt5	815	7	single	single	JJ
cord-016293-pyb00pt5	815	8	nucleotide	nucleotide	JJ
cord-016293-pyb00pt5	815	9	polymorphism	polymorphism	NN
cord-016293-pyb00pt5	815	10	)	)	-RRB-
cord-016293-pyb00pt5	815	11	markers	marker	NNS
cord-016293-pyb00pt5	815	12	are	be	VBP
cord-016293-pyb00pt5	815	13	preferred	prefer	VBN
cord-016293-pyb00pt5	815	14	over	over	IN
cord-016293-pyb00pt5	815	15	microsatellite	microsatellite	JJ
cord-016293-pyb00pt5	815	16	markers	marker	NNS
cord-016293-pyb00pt5	815	17	for	for	IN
cord-016293-pyb00pt5	815	18	association	association	NN
cord-016293-pyb00pt5	815	19	studies	study	NNS
cord-016293-pyb00pt5	815	20	because	because	IN
cord-016293-pyb00pt5	815	21	of	of	IN
cord-016293-pyb00pt5	815	22	their	-PRON-	PRP$
cord-016293-pyb00pt5	815	23	abundance	abundance	NN
cord-016293-pyb00pt5	815	24	along	along	IN
cord-016293-pyb00pt5	815	25	the	the	DT
cord-016293-pyb00pt5	815	26	human	human	JJ
cord-016293-pyb00pt5	815	27	genome	genome	NN
cord-016293-pyb00pt5	815	28	,	,	,
cord-016293-pyb00pt5	815	29	the	the	DT
cord-016293-pyb00pt5	815	30	low	low	JJ
cord-016293-pyb00pt5	815	31	mutation	mutation	NN
cord-016293-pyb00pt5	815	32	rate	rate	NN
cord-016293-pyb00pt5	815	33	,	,	,
cord-016293-pyb00pt5	815	34	and	and	CC
cord-016293-pyb00pt5	815	35	accessibilities	accessibility	NNS
cord-016293-pyb00pt5	815	36	to	to	IN
cord-016293-pyb00pt5	815	37	high	high	JJ
cord-016293-pyb00pt5	815	38	-	-	HYPH
cord-016293-pyb00pt5	815	39	throughput	throughput	NN
cord-016293-pyb00pt5	815	40	genotyping	genotyping	NN
cord-016293-pyb00pt5	815	41	.	.	.
cord-016293-pyb00pt5	816	1	Since	since	IN
cord-016293-pyb00pt5	816	2	most	most	JJS
cord-016293-pyb00pt5	816	3	diseases	disease	NNS
cord-016293-pyb00pt5	816	4	,	,	,
cord-016293-pyb00pt5	816	5	and	and	CC
cord-016293-pyb00pt5	816	6	indeed	indeed	RB
cord-016293-pyb00pt5	816	7	responses	response	NNS
cord-016293-pyb00pt5	816	8	to	to	IN
cord-016293-pyb00pt5	816	9	drug	drug	NN
cord-016293-pyb00pt5	816	10	interventions	intervention	NNS
cord-016293-pyb00pt5	816	11	,	,	,
cord-016293-pyb00pt5	816	12	are	be	VBP
cord-016293-pyb00pt5	816	13	the	the	DT
cord-016293-pyb00pt5	816	14	products	product	NNS
cord-016293-pyb00pt5	816	15	of	of	IN
cord-016293-pyb00pt5	816	16	multiple	multiple	JJ
cord-016293-pyb00pt5	816	17	genetic	genetic	JJ
cord-016293-pyb00pt5	816	18	and	and	CC
cord-016293-pyb00pt5	816	19	environmental	environmental	JJ
cord-016293-pyb00pt5	816	20	factors	factor	NNS
cord-016293-pyb00pt5	816	21	it	-PRON-	PRP
cord-016293-pyb00pt5	816	22	is	be	VBZ
cord-016293-pyb00pt5	816	23	a	a	DT
cord-016293-pyb00pt5	816	24	challenge	challenge	NN
cord-016293-pyb00pt5	816	25	to	to	TO
cord-016293-pyb00pt5	816	26	develop	develop	VB
cord-016293-pyb00pt5	816	27	discriminating	discriminate	VBG
cord-016293-pyb00pt5	816	28	diagnostics	diagnostic	NNS
cord-016293-pyb00pt5	816	29	and	and	CC
cord-016293-pyb00pt5	816	30	,	,	,
cord-016293-pyb00pt5	816	31	even	even	RB
cord-016293-pyb00pt5	816	32	more	more	RBR
cord-016293-pyb00pt5	816	33	so	so	RB
cord-016293-pyb00pt5	816	34	,	,	,
cord-016293-pyb00pt5	816	35	targetedtherapeutics	targetedtherapeutic	NNS
cord-016293-pyb00pt5	816	36	.	.	.
cord-016293-pyb00pt5	817	1	Because	because	IN
cord-016293-pyb00pt5	817	2	mutations	mutation	NNS
cord-016293-pyb00pt5	817	3	involved	involve	VBN
cord-016293-pyb00pt5	817	4	in	in	IN
cord-016293-pyb00pt5	817	5	complex	complex	JJ
cord-016293-pyb00pt5	817	6	diseases	disease	NNS
cord-016293-pyb00pt5	817	7	act	act	NN
cord-016293-pyb00pt5	817	8	probabilisticallythat	probabilisticallythat	RB
cord-016293-pyb00pt5	817	9	is	is	RB
cord-016293-pyb00pt5	817	10	,	,	,
cord-016293-pyb00pt5	817	11	the	the	DT
cord-016293-pyb00pt5	817	12	clinical	clinical	JJ
cord-016293-pyb00pt5	817	13	outcome	outcome	NN
cord-016293-pyb00pt5	817	14	depends	depend	VBZ
cord-016293-pyb00pt5	817	15	on	on	IN
cord-016293-pyb00pt5	817	16	many	many	JJ
cord-016293-pyb00pt5	817	17	factors	factor	NNS
cord-016293-pyb00pt5	817	18	in	in	IN
cord-016293-pyb00pt5	817	19	addition	addition	NN
cord-016293-pyb00pt5	817	20	to	to	IN
cord-016293-pyb00pt5	817	21	variation	variation	NN
cord-016293-pyb00pt5	817	22	in	in	IN
cord-016293-pyb00pt5	817	23	the	the	DT
cord-016293-pyb00pt5	817	24	sequence	sequence	NN
cord-016293-pyb00pt5	817	25	of	of	IN
cord-016293-pyb00pt5	817	26	a	a	DT
cord-016293-pyb00pt5	817	27	single	single	JJ
cord-016293-pyb00pt5	817	28	gene	gene	NN
cord-016293-pyb00pt5	817	29	-the	-the	DT
cord-016293-pyb00pt5	817	30	effect	effect	NN
cord-016293-pyb00pt5	817	31	of	of	IN
cord-016293-pyb00pt5	817	32	any	any	DT
cord-016293-pyb00pt5	817	33	specific	specific	JJ
cord-016293-pyb00pt5	817	34	mutation	mutation	NN
cord-016293-pyb00pt5	817	35	is	be	VBZ
cord-016293-pyb00pt5	817	36	smaller	small	JJR
cord-016293-pyb00pt5	817	37	.	.	.
cord-016293-pyb00pt5	818	1	Thus	thus	RB
cord-016293-pyb00pt5	818	2	,	,	,
cord-016293-pyb00pt5	818	3	such	such	JJ
cord-016293-pyb00pt5	818	4	effects	effect	NNS
cord-016293-pyb00pt5	818	5	can	can	MD
cord-016293-pyb00pt5	818	6	only	only	RB
cord-016293-pyb00pt5	818	7	be	be	VB
cord-016293-pyb00pt5	818	8	revealed	reveal	VBN
cord-016293-pyb00pt5	818	9	by	by	IN
cord-016293-pyb00pt5	818	10	searching	search	VBG
cord-016293-pyb00pt5	818	11	for	for	IN
cord-016293-pyb00pt5	818	12	variants	variant	NNS
cord-016293-pyb00pt5	818	13	that	that	WDT
cord-016293-pyb00pt5	818	14	differ	differ	VBP
cord-016293-pyb00pt5	818	15	in	in	IN
cord-016293-pyb00pt5	818	16	frequency	frequency	NN
cord-016293-pyb00pt5	818	17	among	among	IN
cord-016293-pyb00pt5	818	18	large	large	JJ
cord-016293-pyb00pt5	818	19	numbers	number	NNS
cord-016293-pyb00pt5	818	20	of	of	IN
cord-016293-pyb00pt5	818	21	patients	patient	NNS
cord-016293-pyb00pt5	818	22	and	and	CC
cord-016293-pyb00pt5	818	23	controls	control	NNS
cord-016293-pyb00pt5	818	24	drawn	draw	VBN
cord-016293-pyb00pt5	818	25	from	from	IN
cord-016293-pyb00pt5	818	26	the	the	DT
cord-016293-pyb00pt5	818	27	general	general	JJ
cord-016293-pyb00pt5	818	28	population	population	NN
cord-016293-pyb00pt5	818	29	.	.	.
cord-016293-pyb00pt5	819	1	Analysis	analysis	NN
cord-016293-pyb00pt5	819	2	of	of	IN
cord-016293-pyb00pt5	819	3	these	these	DT
cord-016293-pyb00pt5	819	4	SNP	SNP	NNP
cord-016293-pyb00pt5	819	5	patterns	pattern	NNS
cord-016293-pyb00pt5	819	6	provides	provide	VBZ
cord-016293-pyb00pt5	819	7	a	a	DT
cord-016293-pyb00pt5	819	8	powerful	powerful	JJ
cord-016293-pyb00pt5	819	9	tool	tool	NN
cord-016293-pyb00pt5	819	10	to	to	TO
cord-016293-pyb00pt5	819	11	help	help	VB
cord-016293-pyb00pt5	819	12	achieve	achieve	VB
cord-016293-pyb00pt5	819	13	this	this	DT
cord-016293-pyb00pt5	819	14	goal	goal	NN
cord-016293-pyb00pt5	819	15	.	.	.
cord-016293-pyb00pt5	820	1	Although	although	IN
cord-016293-pyb00pt5	820	2	most	most	JJS
cord-016293-pyb00pt5	820	3	bi	bi	JJ
cord-016293-pyb00pt5	820	4	-	-	JJ
cord-016293-pyb00pt5	820	5	alleic	alleic	NNS
cord-016293-pyb00pt5	820	6	SNPs	snp	NNS
cord-016293-pyb00pt5	820	7	are	be	VBP
cord-016293-pyb00pt5	820	8	rare	rare	JJ
cord-016293-pyb00pt5	820	9	,	,	,
cord-016293-pyb00pt5	820	10	it	-PRON-	PRP
cord-016293-pyb00pt5	820	11	has	have	VBZ
cord-016293-pyb00pt5	820	12	been	be	VBN
cord-016293-pyb00pt5	820	13	estimated	estimate	VBN
cord-016293-pyb00pt5	820	14	that	that	IN
cord-016293-pyb00pt5	820	15	just	just	RB
cord-016293-pyb00pt5	820	16	over	over	IN
cord-016293-pyb00pt5	820	17	5	5	CD
cord-016293-pyb00pt5	820	18	million	million	CD
cord-016293-pyb00pt5	820	19	common	common	JJ
cord-016293-pyb00pt5	820	20	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	820	21	,	,	,
cord-016293-pyb00pt5	820	22	each	each	DT
cord-016293-pyb00pt5	820	23	with	with	IN
cord-016293-pyb00pt5	820	24	a	a	DT
cord-016293-pyb00pt5	820	25	frequency	frequency	NN
cord-016293-pyb00pt5	820	26	of	of	IN
cord-016293-pyb00pt5	820	27	between	between	IN
cord-016293-pyb00pt5	820	28	10	10	CD
cord-016293-pyb00pt5	820	29	and	and	CC
cord-016293-pyb00pt5	820	30	50	50	CD
cord-016293-pyb00pt5	820	31	%	%	NN
cord-016293-pyb00pt5	820	32	,	,	,
cord-016293-pyb00pt5	820	33	account	account	VBP
cord-016293-pyb00pt5	820	34	for	for	IN
cord-016293-pyb00pt5	820	35	the	the	DT
cord-016293-pyb00pt5	820	36	bulk	bulk	NN
cord-016293-pyb00pt5	820	37	of	of	IN
cord-016293-pyb00pt5	820	38	the	the	DT
cord-016293-pyb00pt5	820	39	DNA	dna	NN
cord-016293-pyb00pt5	820	40	sequence	sequence	NN
cord-016293-pyb00pt5	820	41	difference	difference	NN
cord-016293-pyb00pt5	820	42	between	between	IN
cord-016293-pyb00pt5	820	43	humans	human	NNS
cord-016293-pyb00pt5	820	44	.	.	.
cord-016293-pyb00pt5	821	1	Such	such	JJ
cord-016293-pyb00pt5	821	2	SNPs	snp	NNS
cord-016293-pyb00pt5	821	3	are	be	VBP
cord-016293-pyb00pt5	821	4	present	present	JJ
cord-016293-pyb00pt5	821	5	in	in	IN
cord-016293-pyb00pt5	821	6	the	the	DT
cord-016293-pyb00pt5	821	7	human	human	JJ
cord-016293-pyb00pt5	821	8	genome	genome	NN
cord-016293-pyb00pt5	821	9	once	once	RB
cord-016293-pyb00pt5	821	10	every	every	DT
cord-016293-pyb00pt5	821	11	600	600	CD
cord-016293-pyb00pt5	821	12	base	base	NN
cord-016293-pyb00pt5	821	13	pairs	pair	NNS
cord-016293-pyb00pt5	821	14	or	or	CC
cord-016293-pyb00pt5	821	15	so	so	RB
cord-016293-pyb00pt5	821	16	.	.	.
cord-016293-pyb00pt5	822	1	As	as	IN
cord-016293-pyb00pt5	822	2	is	be	VBZ
cord-016293-pyb00pt5	822	3	to	to	TO
cord-016293-pyb00pt5	822	4	be	be	VB
cord-016293-pyb00pt5	822	5	expected	expect	VBN
cord-016293-pyb00pt5	822	6	from	from	IN
cord-016293-pyb00pt5	822	7	linkage	linkage	NN
cord-016293-pyb00pt5	822	8	disequilibrium	disequilibrium	NN
cord-016293-pyb00pt5	822	9	studies	study	NNS
cord-016293-pyb00pt5	822	10	,	,	,
cord-016293-pyb00pt5	822	11	alleles	allele	NNS
cord-016293-pyb00pt5	822	12	making	make	VBG
cord-016293-pyb00pt5	822	13	up	up	RP
cord-016293-pyb00pt5	822	14	blocks	block	NNS
cord-016293-pyb00pt5	822	15	of	of	IN
cord-016293-pyb00pt5	822	16	such	such	JJ
cord-016293-pyb00pt5	822	17	SNPs	snp	NNS
cord-016293-pyb00pt5	822	18	in	in	IN
cord-016293-pyb00pt5	822	19	close	close	JJ
cord-016293-pyb00pt5	822	20	physical	physical	JJ
cord-016293-pyb00pt5	822	21	proximity	proximity	NN
cord-016293-pyb00pt5	822	22	are	be	VBP
cord-016293-pyb00pt5	822	23	often	often	RB
cord-016293-pyb00pt5	822	24	correlated	correlate	VBN
cord-016293-pyb00pt5	822	25	,	,	,
cord-016293-pyb00pt5	822	26	resulting	result	VBG
cord-016293-pyb00pt5	822	27	in	in	IN
cord-016293-pyb00pt5	822	28	reduced	reduce	VBN
cord-016293-pyb00pt5	822	29	genetic	genetic	JJ
cord-016293-pyb00pt5	822	30	variability	variability	NN
cord-016293-pyb00pt5	822	31	and	and	CC
cord-016293-pyb00pt5	822	32	defining	define	VBG
cord-016293-pyb00pt5	822	33	a	a	DT
cord-016293-pyb00pt5	822	34	limited	limited	JJ
cord-016293-pyb00pt5	822	35	number	number	NN
cord-016293-pyb00pt5	822	36	of	of	IN
cord-016293-pyb00pt5	822	37	"	"	``
cord-016293-pyb00pt5	822	38	SNP	SNP	NNP
cord-016293-pyb00pt5	822	39	haplotypes	haplotype	NNS
cord-016293-pyb00pt5	822	40	,	,	,
cord-016293-pyb00pt5	822	41	"	"	``
cord-016293-pyb00pt5	822	42	each	each	DT
cord-016293-pyb00pt5	822	43	of	of	IN
cord-016293-pyb00pt5	822	44	which	which	WDT
cord-016293-pyb00pt5	822	45	reflects	reflect	VBZ
cord-016293-pyb00pt5	822	46	descent	descent	NN
cord-016293-pyb00pt5	822	47	from	from	IN
cord-016293-pyb00pt5	822	48	a	a	DT
cord-016293-pyb00pt5	822	49	single	single	JJ
cord-016293-pyb00pt5	822	50	,	,	,
cord-016293-pyb00pt5	822	51	ancient	ancient	JJ
cord-016293-pyb00pt5	822	52	ancestral	ancestral	JJ
cord-016293-pyb00pt5	822	53	chromosome	chromosome	NN
cord-016293-pyb00pt5	822	54	.	.	.
cord-016293-pyb00pt5	823	1	In	in	IN
cord-016293-pyb00pt5	823	2	2001	2001	CD
cord-016293-pyb00pt5	823	3	Cox	Cox	NNP
cord-016293-pyb00pt5	823	4	's	's	POS
cord-016293-pyb00pt5	823	5	group	group	NN
cord-016293-pyb00pt5	823	6	,	,	,
cord-016293-pyb00pt5	823	7	using	use	VBG
cord-016293-pyb00pt5	823	8	high	high	JJ
cord-016293-pyb00pt5	823	9	level	level	NN
cord-016293-pyb00pt5	823	10	scanning	scanning	NN
cord-016293-pyb00pt5	823	11	with	with	IN
cord-016293-pyb00pt5	823	12	some	some	DT
cord-016293-pyb00pt5	823	13	old	old	JJ
cord-016293-pyb00pt5	823	14	-	-	HYPH
cord-016293-pyb00pt5	823	15	fashioned	fashioned	JJ
cord-016293-pyb00pt5	823	16	somatic	somatic	JJ
cord-016293-pyb00pt5	823	17	cell	cell	NN
cord-016293-pyb00pt5	823	18	genetics	genetic	NNS
cord-016293-pyb00pt5	823	19	,	,	,
cord-016293-pyb00pt5	823	20	constructed	construct	VBD
cord-016293-pyb00pt5	823	21	the	the	DT
cord-016293-pyb00pt5	823	22	SNP	SNP	NNP
cord-016293-pyb00pt5	823	23	map	map	NN
cord-016293-pyb00pt5	823	24	of	of	IN
cord-016293-pyb00pt5	823	25	Chromosome	chromosome	NN
cord-016293-pyb00pt5	823	26	21.The	21.the	CD
cord-016293-pyb00pt5	823	27	surprising	surprising	JJ
cord-016293-pyb00pt5	823	28	findings	finding	NNS
cord-016293-pyb00pt5	823	29	were	be	VBD
cord-016293-pyb00pt5	823	30	blocks	block	NNS
cord-016293-pyb00pt5	823	31	of	of	IN
cord-016293-pyb00pt5	823	32	limited	limited	JJ
cord-016293-pyb00pt5	823	33	haplotype	haplotype	NN
cord-016293-pyb00pt5	823	34	diversity	diversity	NN
cord-016293-pyb00pt5	823	35	in	in	IN
cord-016293-pyb00pt5	823	36	which	which	WDT
cord-016293-pyb00pt5	823	37	more	more	JJR
cord-016293-pyb00pt5	823	38	than	than	IN
cord-016293-pyb00pt5	823	39	80	80	CD
cord-016293-pyb00pt5	823	40	%	%	NN
cord-016293-pyb00pt5	823	41	of	of	IN
cord-016293-pyb00pt5	823	42	a	a	DT
cord-016293-pyb00pt5	823	43	global	global	JJ
cord-016293-pyb00pt5	823	44	human	human	JJ
cord-016293-pyb00pt5	823	45	sample	sample	NN
cord-016293-pyb00pt5	823	46	can	can	MD
cord-016293-pyb00pt5	823	47	typically	typically	RB
cord-016293-pyb00pt5	823	48	be	be	VB
cord-016293-pyb00pt5	823	49	characterized	characterize	VBN
cord-016293-pyb00pt5	823	50	by	by	IN
cord-016293-pyb00pt5	823	51	only	only	RB
cord-016293-pyb00pt5	823	52	three	three	CD
cord-016293-pyb00pt5	823	53	common	common	JJ
cord-016293-pyb00pt5	823	54	haplotypes	haplotype	NNS
cord-016293-pyb00pt5	823	55	(	(	-LRB-
cord-016293-pyb00pt5	823	56	interestingly	interestingly	RB
cord-016293-pyb00pt5	823	57	enough	enough	RB
cord-016293-pyb00pt5	823	58	the	the	DT
cord-016293-pyb00pt5	823	59	prevalence	prevalence	NN
cord-016293-pyb00pt5	823	60	of	of	IN
cord-016293-pyb00pt5	823	61	each	each	DT
cord-016293-pyb00pt5	823	62	hapolytype	hapolytype	NN
cord-016293-pyb00pt5	823	63	in	in	IN
cord-016293-pyb00pt5	823	64	the	the	DT
cord-016293-pyb00pt5	823	65	examined	examine	VBN
cord-016293-pyb00pt5	823	66	population	population	NN
cord-016293-pyb00pt5	823	67	was	be	VBD
cord-016293-pyb00pt5	823	68	in	in	IN
cord-016293-pyb00pt5	823	69	the	the	DT
cord-016293-pyb00pt5	823	70	ratio	ratio	NN
cord-016293-pyb00pt5	824	1	50:25:12.5).From	50:25:12.5).from	CD
cord-016293-pyb00pt5	825	1	this	this	DT
cord-016293-pyb00pt5	825	2	the	the	DT
cord-016293-pyb00pt5	825	3	conclusion	conclusion	NN
cord-016293-pyb00pt5	825	4	could	could	MD
cord-016293-pyb00pt5	825	5	be	be	VB
cord-016293-pyb00pt5	825	6	drawn	draw	VBN
cord-016293-pyb00pt5	825	7	that	that	IN
cord-016293-pyb00pt5	825	8	by	by	IN
cord-016293-pyb00pt5	825	9	comparing	compare	VBG
cord-016293-pyb00pt5	825	10	the	the	DT
cord-016293-pyb00pt5	825	11	frequency	frequency	NN
cord-016293-pyb00pt5	825	12	of	of	IN
cord-016293-pyb00pt5	825	13	genetic	genetic	JJ
cord-016293-pyb00pt5	825	14	variants	variant	NNS
cord-016293-pyb00pt5	825	15	in	in	IN
cord-016293-pyb00pt5	825	16	unrelated	unrelated	JJ
cord-016293-pyb00pt5	825	17	cases	case	NNS
cord-016293-pyb00pt5	825	18	and	and	CC
cord-016293-pyb00pt5	825	19	controls	control	NNS
cord-016293-pyb00pt5	825	20	,	,	,
cord-016293-pyb00pt5	825	21	genetic	genetic	JJ
cord-016293-pyb00pt5	825	22	association	association	NN
cord-016293-pyb00pt5	825	23	studies	study	NNS
cord-016293-pyb00pt5	825	24	could	could	MD
cord-016293-pyb00pt5	825	25	potentially	potentially	RB
cord-016293-pyb00pt5	825	26	identify	identify	VB
cord-016293-pyb00pt5	825	27	specific	specific	JJ
cord-016293-pyb00pt5	825	28	haplotypes	haplotype	NNS
cord-016293-pyb00pt5	825	29	in	in	IN
cord-016293-pyb00pt5	825	30	the	the	DT
cord-016293-pyb00pt5	825	31	human	human	JJ
cord-016293-pyb00pt5	825	32	genome	genome	NN
cord-016293-pyb00pt5	825	33	that	that	WDT
cord-016293-pyb00pt5	825	34	play	play	VBP
cord-016293-pyb00pt5	825	35	important	important	JJ
cord-016293-pyb00pt5	825	36	roles	role	NNS
cord-016293-pyb00pt5	825	37	in	in	IN
cord-016293-pyb00pt5	825	38	disease	disease	NN
cord-016293-pyb00pt5	825	39	,	,	,
cord-016293-pyb00pt5	825	40	without	without	IN
cord-016293-pyb00pt5	825	41	need	need	NN
cord-016293-pyb00pt5	825	42	of	of	IN
cord-016293-pyb00pt5	825	43	knowledge	knowledge	NN
cord-016293-pyb00pt5	825	44	of	of	IN
cord-016293-pyb00pt5	825	45	the	the	DT
cord-016293-pyb00pt5	825	46	history	history	NN
cord-016293-pyb00pt5	825	47	or	or	CC
cord-016293-pyb00pt5	825	48	source	source	NN
cord-016293-pyb00pt5	825	49	of	of	IN
cord-016293-pyb00pt5	825	50	the	the	DT
cord-016293-pyb00pt5	825	51	underlying	underlying	JJ
cord-016293-pyb00pt5	825	52	sequence	sequence	NN
cord-016293-pyb00pt5	825	53	,	,	,
cord-016293-pyb00pt5	825	54	which	which	WDT
cord-016293-pyb00pt5	825	55	hypothesis	hypothesis	NN
cord-016293-pyb00pt5	825	56	they	-PRON-	PRP
cord-016293-pyb00pt5	825	57	subsequently	subsequently	RB
cord-016293-pyb00pt5	825	58	went	go	VBD
cord-016293-pyb00pt5	825	59	on	on	RP
cord-016293-pyb00pt5	825	60	to	to	TO
cord-016293-pyb00pt5	825	61	prove	prove	VB
cord-016293-pyb00pt5	825	62	.	.	.
cord-016293-pyb00pt5	826	1	Following	follow	VBG
cord-016293-pyb00pt5	826	2	Cox	Cox	NNP
cord-016293-pyb00pt5	826	3	et	et	NNP
cord-016293-pyb00pt5	826	4	al	al	NNP
cord-016293-pyb00pt5	826	5	.	.	.
cord-016293-pyb00pt5	827	1	pioneering	pioneer	VBG
cord-016293-pyb00pt5	827	2	work	work	NN
cord-016293-pyb00pt5	827	3	on	on	IN
cord-016293-pyb00pt5	827	4	"	"	``
cord-016293-pyb00pt5	827	5	blocking	block	VBG
cord-016293-pyb00pt5	827	6	"	"	''
cord-016293-pyb00pt5	827	7	Chromosome	chromosome	NN
cord-016293-pyb00pt5	827	8	21	21	CD
cord-016293-pyb00pt5	827	9	into	into	IN
cord-016293-pyb00pt5	827	10	characteristic	characteristic	JJ
cord-016293-pyb00pt5	827	11	haplotypes	haplotype	NNS
cord-016293-pyb00pt5	828	1	,	,	,
cord-016293-pyb00pt5	828	2	Tien	Tien	NNP
cord-016293-pyb00pt5	828	3	Chen	Chen	NNP
cord-016293-pyb00pt5	828	4	came	come	VBD
cord-016293-pyb00pt5	828	5	to	to	TO
cord-016293-pyb00pt5	828	6	visit	visit	VB
cord-016293-pyb00pt5	828	7	him	-PRON-	PRP
cord-016293-pyb00pt5	828	8	from	from	IN
cord-016293-pyb00pt5	828	9	University	University	NNP
cord-016293-pyb00pt5	828	10	of	of	IN
cord-016293-pyb00pt5	828	11	Southern	Southern	NNP
cord-016293-pyb00pt5	828	12	California	California	NNP
cord-016293-pyb00pt5	828	13	and	and	CC
cord-016293-pyb00pt5	828	14	following	follow	VBG
cord-016293-pyb00pt5	828	15	the	the	DT
cord-016293-pyb00pt5	828	16	visit	visit	NN
cord-016293-pyb00pt5	828	17	his	-PRON-	PRP$
cord-016293-pyb00pt5	828	18	group	group	NN
cord-016293-pyb00pt5	828	19	developed	develop	VBD
cord-016293-pyb00pt5	828	20	discriminating	discriminate	VBG
cord-016293-pyb00pt5	828	21	algorithms	algorithm	NNS
cord-016293-pyb00pt5	828	22	which	which	WDT
cord-016293-pyb00pt5	828	23	took	take	VBD
cord-016293-pyb00pt5	828	24	advantage	advantage	NN
cord-016293-pyb00pt5	828	25	of	of	IN
cord-016293-pyb00pt5	828	26	the	the	DT
cord-016293-pyb00pt5	828	27	fact	fact	NN
cord-016293-pyb00pt5	828	28	that	that	IN
cord-016293-pyb00pt5	828	29	the	the	DT
cord-016293-pyb00pt5	828	30	haplotype	haplotype	NN
cord-016293-pyb00pt5	828	31	block	block	NN
cord-016293-pyb00pt5	828	32	structure	structure	NN
cord-016293-pyb00pt5	828	33	can	can	MD
cord-016293-pyb00pt5	828	34	be	be	VB
cord-016293-pyb00pt5	828	35	decomposed	decompose	VBN
cord-016293-pyb00pt5	828	36	into	into	IN
cord-016293-pyb00pt5	828	37	large	large	JJ
cord-016293-pyb00pt5	828	38	blocks	block	NNS
cord-016293-pyb00pt5	828	39	with	with	IN
cord-016293-pyb00pt5	828	40	high	high	JJ
cord-016293-pyb00pt5	828	41	linkage	linkage	NN
cord-016293-pyb00pt5	828	42	disequilibrium	disequilibrium	NN
cord-016293-pyb00pt5	828	43	and	and	CC
cord-016293-pyb00pt5	828	44	relatively	relatively	RB
cord-016293-pyb00pt5	828	45	limited	limited	JJ
cord-016293-pyb00pt5	828	46	haplotype	haplotype	NN
cord-016293-pyb00pt5	828	47	diversity	diversity	NN
cord-016293-pyb00pt5	828	48	,	,	,
cord-016293-pyb00pt5	828	49	separated	separate	VBN
cord-016293-pyb00pt5	828	50	by	by	IN
cord-016293-pyb00pt5	828	51	short	short	JJ
cord-016293-pyb00pt5	828	52	regions	region	NNS
cord-016293-pyb00pt5	828	53	of	of	IN
cord-016293-pyb00pt5	828	54	low	low	JJ
cord-016293-pyb00pt5	828	55	disequilibrium	disequilibrium	NN
cord-016293-pyb00pt5	828	56	.	.	.
cord-016293-pyb00pt5	829	1	One	one	CD
cord-016293-pyb00pt5	829	2	of	of	IN
cord-016293-pyb00pt5	829	3	the	the	DT
cord-016293-pyb00pt5	829	4	practical	practical	JJ
cord-016293-pyb00pt5	829	5	implications	implication	NNS
cord-016293-pyb00pt5	829	6	of	of	IN
cord-016293-pyb00pt5	829	7	this	this	DT
cord-016293-pyb00pt5	829	8	observation	observation	NN
cord-016293-pyb00pt5	829	9	is	be	VBZ
cord-016293-pyb00pt5	829	10	as	as	RB
cord-016293-pyb00pt5	829	11	suggested	suggest	VBN
cord-016293-pyb00pt5	829	12	by	by	IN
cord-016293-pyb00pt5	829	13	Cox	Cox	NNP
cord-016293-pyb00pt5	829	14	that	that	IN
cord-016293-pyb00pt5	829	15	only	only	RB
cord-016293-pyb00pt5	829	16	a	a	DT
cord-016293-pyb00pt5	829	17	small	small	JJ
cord-016293-pyb00pt5	829	18	fraction	fraction	NN
cord-016293-pyb00pt5	829	19	of	of	IN
cord-016293-pyb00pt5	829	20	all	all	PDT
cord-016293-pyb00pt5	829	21	the	the	DT
cord-016293-pyb00pt5	829	22	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	829	23	they	-PRON-	PRP
cord-016293-pyb00pt5	829	24	refer	refer	VBP
cord-016293-pyb00pt5	829	25	to	to	IN
cord-016293-pyb00pt5	829	26	as	as	IN
cord-016293-pyb00pt5	829	27	"	"	``
cord-016293-pyb00pt5	829	28	tag	tag	NN
cord-016293-pyb00pt5	829	29	"	"	''
cord-016293-pyb00pt5	829	30	SNPs	snp	NNS
cord-016293-pyb00pt5	829	31	can	can	MD
cord-016293-pyb00pt5	829	32	be	be	VB
cord-016293-pyb00pt5	829	33	chosen	choose	VBN
cord-016293-pyb00pt5	829	34	for	for	IN
cord-016293-pyb00pt5	829	35	mapping	mapping	NN
cord-016293-pyb00pt5	829	36	genes	gene	NNS
cord-016293-pyb00pt5	829	37	responsible	responsible	JJ
cord-016293-pyb00pt5	829	38	for	for	IN
cord-016293-pyb00pt5	829	39	complex	complex	JJ
cord-016293-pyb00pt5	829	40	human	human	JJ
cord-016293-pyb00pt5	829	41	diseases	disease	NNS
cord-016293-pyb00pt5	829	42	,	,	,
cord-016293-pyb00pt5	829	43	which	which	WDT
cord-016293-pyb00pt5	829	44	can	can	MD
cord-016293-pyb00pt5	829	45	significantly	significantly	RB
cord-016293-pyb00pt5	829	46	reduce	reduce	VB
cord-016293-pyb00pt5	829	47	genotyping	genotyping	NN
cord-016293-pyb00pt5	829	48	effort	effort	NN
cord-016293-pyb00pt5	829	49	,	,	,
cord-016293-pyb00pt5	829	50	without	without	IN
cord-016293-pyb00pt5	829	51	much	much	JJ
cord-016293-pyb00pt5	829	52	loss	loss	NN
cord-016293-pyb00pt5	829	53	of	of	IN
cord-016293-pyb00pt5	829	54	power	power	NN
cord-016293-pyb00pt5	829	55	.	.	.
cord-016293-pyb00pt5	830	1	They	-PRON-	PRP
cord-016293-pyb00pt5	830	2	developed	develop	VBD
cord-016293-pyb00pt5	830	3	algorithms	algorithm	NNS
cord-016293-pyb00pt5	830	4	to	to	TO
cord-016293-pyb00pt5	830	5	partition	partition	VB
cord-016293-pyb00pt5	830	6	haplotypes	haplotype	NNS
cord-016293-pyb00pt5	830	7	into	into	IN
cord-016293-pyb00pt5	830	8	blocks	block	NNS
cord-016293-pyb00pt5	830	9	with	with	IN
cord-016293-pyb00pt5	830	10	the	the	DT
cord-016293-pyb00pt5	830	11	minimum	minimum	JJ
cord-016293-pyb00pt5	830	12	number	number	NN
cord-016293-pyb00pt5	830	13	of	of	IN
cord-016293-pyb00pt5	830	14	tag	tag	NN
cord-016293-pyb00pt5	830	15	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	830	16	for	for	IN
cord-016293-pyb00pt5	830	17	an	an	DT
cord-016293-pyb00pt5	830	18	entire	entire	JJ
cord-016293-pyb00pt5	830	19	chromosome	chromosome	NN
cord-016293-pyb00pt5	830	20	.	.	.
cord-016293-pyb00pt5	831	1	In	in	IN
cord-016293-pyb00pt5	831	2	2005	2005	CD
cord-016293-pyb00pt5	831	3	they	-PRON-	PRP
cord-016293-pyb00pt5	831	4	reported	report	VBD
cord-016293-pyb00pt5	831	5	that	that	IN
cord-016293-pyb00pt5	831	6	they	-PRON-	PRP
cord-016293-pyb00pt5	831	7	had	have	VBD
cord-016293-pyb00pt5	831	8	developed	develop	VBN
cord-016293-pyb00pt5	831	9	an	an	DT
cord-016293-pyb00pt5	831	10	optimized	optimize	VBN
cord-016293-pyb00pt5	831	11	suite	suite	NN
cord-016293-pyb00pt5	831	12	of	of	IN
cord-016293-pyb00pt5	831	13	programs	program	NNS
cord-016293-pyb00pt5	831	14	to	to	TO
cord-016293-pyb00pt5	831	15	analyze	analyze	VB
cord-016293-pyb00pt5	831	16	these	these	DT
cord-016293-pyb00pt5	831	17	block	block	NN
cord-016293-pyb00pt5	831	18	linkage	linkage	NN
cord-016293-pyb00pt5	831	19	disequilibrium	disequilibrium	NN
cord-016293-pyb00pt5	831	20	patterns	pattern	NNS
cord-016293-pyb00pt5	831	21	and	and	CC
cord-016293-pyb00pt5	831	22	to	to	TO
cord-016293-pyb00pt5	831	23	select	select	VB
cord-016293-pyb00pt5	831	24	the	the	DT
cord-016293-pyb00pt5	831	25	corresponding	corresponding	JJ
cord-016293-pyb00pt5	831	26	tag	tag	NN
cord-016293-pyb00pt5	831	27	SNPs	snp	NNS
cord-016293-pyb00pt5	831	28	that	that	WDT
cord-016293-pyb00pt5	831	29	will	will	MD
cord-016293-pyb00pt5	831	30	pick	pick	VB
cord-016293-pyb00pt5	831	31	the	the	DT
cord-016293-pyb00pt5	831	32	minimum	minimum	JJ
cord-016293-pyb00pt5	831	33	number	number	NN
cord-016293-pyb00pt5	831	34	of	of	IN
cord-016293-pyb00pt5	831	35	tags	tag	NNS
cord-016293-pyb00pt5	831	36	for	for	IN
cord-016293-pyb00pt5	831	37	the	the	DT
cord-016293-pyb00pt5	831	38	given	give	VBN
cord-016293-pyb00pt5	831	39	criteria	criterion	NNS
cord-016293-pyb00pt5	831	40	.	.	.
cord-016293-pyb00pt5	832	1	In	in	IN
cord-016293-pyb00pt5	832	2	addition	addition	NN
cord-016293-pyb00pt5	832	3	the	the	DT
cord-016293-pyb00pt5	832	4	updated	update	VBN
cord-016293-pyb00pt5	832	5	suite	suite	NN
cord-016293-pyb00pt5	832	6	allows	allow	VBZ
cord-016293-pyb00pt5	832	7	haplotype	haplotype	NNP
cord-016293-pyb00pt5	832	8	data	datum	NNS
cord-016293-pyb00pt5	832	9	and	and	CC
cord-016293-pyb00pt5	832	10	genotype	genotype	NN
cord-016293-pyb00pt5	832	11	data	datum	NNS
cord-016293-pyb00pt5	832	12	from	from	IN
cord-016293-pyb00pt5	832	13	unrelated	unrelated	JJ
cord-016293-pyb00pt5	832	14	individuals	individual	NNS
cord-016293-pyb00pt5	832	15	and	and	CC
cord-016293-pyb00pt5	832	16	from	from	IN
cord-016293-pyb00pt5	832	17	general	general	JJ
cord-016293-pyb00pt5	832	18	pedigrees	pedigree	NNS
cord-016293-pyb00pt5	832	19	to	to	TO
cord-016293-pyb00pt5	832	20	be	be	VB
cord-016293-pyb00pt5	832	21	analyzed	analyze	VBN
cord-016293-pyb00pt5	832	22	.	.	.
cord-016293-pyb00pt5	833	1	Using	use	VBG
cord-016293-pyb00pt5	833	2	an	an	DT
cord-016293-pyb00pt5	833	3	approach	approach	NN
cord-016293-pyb00pt5	833	4	similar	similar	JJ
cord-016293-pyb00pt5	833	5	to	to	IN
cord-016293-pyb00pt5	833	6	Richard	Richard	NNP
cord-016293-pyb00pt5	833	7	Michelmore	Michelmore	NNP
cord-016293-pyb00pt5	833	8	's	's	POS
cord-016293-pyb00pt5	833	9	bulk	bulk	JJ
cord-016293-pyb00pt5	833	10	segregant	segregant	NN
cord-016293-pyb00pt5	833	11	analysis	analysis	NN
cord-016293-pyb00pt5	833	12	in	in	IN
cord-016293-pyb00pt5	833	13	plants	plant	NNS
cord-016293-pyb00pt5	833	14	of	of	IN
cord-016293-pyb00pt5	833	15	more	more	JJR
cord-016293-pyb00pt5	833	16	than	than	IN
cord-016293-pyb00pt5	833	17	a	a	DT
cord-016293-pyb00pt5	833	18	decade	decade	NN
cord-016293-pyb00pt5	833	19	previously	previously	RB
cord-016293-pyb00pt5	833	20	,	,	,
cord-016293-pyb00pt5	833	21	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	833	22	subsequently	subsequently	RB
cord-016293-pyb00pt5	833	23	made	make	VBD
cord-016293-pyb00pt5	833	24	use	use	NN
cord-016293-pyb00pt5	833	25	of	of	IN
cord-016293-pyb00pt5	833	26	these	these	DT
cord-016293-pyb00pt5	833	27	SNP	SNP	NNP
cord-016293-pyb00pt5	833	28	haplotype	haplotype	NN
cord-016293-pyb00pt5	833	29	and	and	CC
cord-016293-pyb00pt5	833	30	statistical	statistical	JJ
cord-016293-pyb00pt5	833	31	probability	probability	NN
cord-016293-pyb00pt5	833	32	tools	tool	NNS
cord-016293-pyb00pt5	833	33	to	to	TO
cord-016293-pyb00pt5	833	34	estimate	estimate	VB
cord-016293-pyb00pt5	833	35	total	total	JJ
cord-016293-pyb00pt5	833	36	genetic	genetic	JJ
cord-016293-pyb00pt5	833	37	variability	variability	NN
cord-016293-pyb00pt5	833	38	of	of	IN
cord-016293-pyb00pt5	833	39	a	a	DT
cord-016293-pyb00pt5	833	40	particular	particular	JJ
cord-016293-pyb00pt5	833	41	complex	complex	JJ
cord-016293-pyb00pt5	833	42	trait	trait	NN
cord-016293-pyb00pt5	833	43	coded	code	VBN
cord-016293-pyb00pt5	833	44	for	for	IN
cord-016293-pyb00pt5	833	45	by	by	IN
cord-016293-pyb00pt5	833	46	many	many	JJ
cord-016293-pyb00pt5	833	47	genes	gene	NNS
cord-016293-pyb00pt5	833	48	,	,	,
cord-016293-pyb00pt5	833	49	with	with	IN
cord-016293-pyb00pt5	833	50	any	any	DT
cord-016293-pyb00pt5	833	51	single	single	JJ
cord-016293-pyb00pt5	833	52	gene	gene	NN
cord-016293-pyb00pt5	833	53	accounting	accounting	NN
cord-016293-pyb00pt5	833	54	for	for	IN
cord-016293-pyb00pt5	833	55	no	no	DT
cord-016293-pyb00pt5	833	56	more	more	JJR
cord-016293-pyb00pt5	833	57	than	than	IN
cord-016293-pyb00pt5	833	58	a	a	DT
cord-016293-pyb00pt5	833	59	few	few	JJ
cord-016293-pyb00pt5	833	60	percent	percent	NN
cord-016293-pyb00pt5	833	61	of	of	IN
cord-016293-pyb00pt5	833	62	the	the	DT
cord-016293-pyb00pt5	833	63	overall	overall	JJ
cord-016293-pyb00pt5	833	64	variability	variability	NN
cord-016293-pyb00pt5	833	65	of	of	IN
cord-016293-pyb00pt5	833	66	the	the	DT
cord-016293-pyb00pt5	833	67	trait	trait	NN
cord-016293-pyb00pt5	833	68	.	.	.
cord-016293-pyb00pt5	834	1	Cox	Cox	NNP
cord-016293-pyb00pt5	834	2	's	's	POS
cord-016293-pyb00pt5	834	3	group	group	NN
cord-016293-pyb00pt5	834	4	have	have	VBP
cord-016293-pyb00pt5	834	5	determined	determine	VBN
cord-016293-pyb00pt5	834	6	that	that	IN
cord-016293-pyb00pt5	834	7	fewer	few	JJR
cord-016293-pyb00pt5	834	8	than	than	IN
cord-016293-pyb00pt5	834	9	1000	1000	CD
cord-016293-pyb00pt5	834	10	total	total	JJ
cord-016293-pyb00pt5	834	11	individuals	individual	NNS
cord-016293-pyb00pt5	834	12	provide	provide	VBP
cord-016293-pyb00pt5	834	13	adequate	adequate	JJ
cord-016293-pyb00pt5	834	14	power	power	NN
cord-016293-pyb00pt5	834	15	to	to	TO
cord-016293-pyb00pt5	834	16	identify	identify	VB
cord-016293-pyb00pt5	834	17	genes	gene	NNS
cord-016293-pyb00pt5	834	18	accounting	account	VBG
cord-016293-pyb00pt5	834	19	for	for	IN
cord-016293-pyb00pt5	834	20	only	only	RB
cord-016293-pyb00pt5	834	21	a	a	DT
cord-016293-pyb00pt5	834	22	few	few	JJ
cord-016293-pyb00pt5	834	23	percent	percent	NN
cord-016293-pyb00pt5	834	24	of	of	IN
cord-016293-pyb00pt5	834	25	the	the	DT
cord-016293-pyb00pt5	834	26	overall	overall	JJ
cord-016293-pyb00pt5	834	27	genetic	genetic	JJ
cord-016293-pyb00pt5	834	28	variability	variability	NN
cord-016293-pyb00pt5	834	29	of	of	IN
cord-016293-pyb00pt5	834	30	a	a	DT
cord-016293-pyb00pt5	834	31	complex	complex	JJ
cord-016293-pyb00pt5	834	32	trait	trait	NN
cord-016293-pyb00pt5	834	33	,	,	,
cord-016293-pyb00pt5	834	34	even	even	RB
cord-016293-pyb00pt5	834	35	using	use	VBG
cord-016293-pyb00pt5	834	36	the	the	DT
cord-016293-pyb00pt5	834	37	very	very	RB
cord-016293-pyb00pt5	834	38	stringent	stringent	JJ
cord-016293-pyb00pt5	834	39	significance	significance	NN
cord-016293-pyb00pt5	834	40	levels	level	NNS
cord-016293-pyb00pt5	834	41	required	require	VBN
cord-016293-pyb00pt5	834	42	when	when	WRB
cord-016293-pyb00pt5	834	43	testing	test	VBG
cord-016293-pyb00pt5	834	44	large	large	JJ
cord-016293-pyb00pt5	834	45	numbers	number	NNS
cord-016293-pyb00pt5	834	46	of	of	IN
cord-016293-pyb00pt5	834	47	DNA	dna	NN
cord-016293-pyb00pt5	834	48	variants	variant	NNS
cord-016293-pyb00pt5	834	49	.	.	.
cord-016293-pyb00pt5	835	1	From	from	IN
cord-016293-pyb00pt5	835	2	this	this	DT
cord-016293-pyb00pt5	835	3	it	-PRON-	PRP
cord-016293-pyb00pt5	835	4	is	be	VBZ
cord-016293-pyb00pt5	835	5	possible	possible	JJ
cord-016293-pyb00pt5	835	6	to	to	TO
cord-016293-pyb00pt5	835	7	identify	identify	VB
cord-016293-pyb00pt5	835	8	the	the	DT
cord-016293-pyb00pt5	835	9	set	set	NN
cord-016293-pyb00pt5	835	10	of	of	IN
cord-016293-pyb00pt5	835	11	major	major	JJ
cord-016293-pyb00pt5	835	12	genetic	genetic	JJ
cord-016293-pyb00pt5	835	13	risk	risk	NN
cord-016293-pyb00pt5	835	14	factors	factor	NNS
cord-016293-pyb00pt5	835	15	contributing	contribute	VBG
cord-016293-pyb00pt5	835	16	to	to	IN
cord-016293-pyb00pt5	835	17	the	the	DT
cord-016293-pyb00pt5	835	18	variability	variability	NN
cord-016293-pyb00pt5	835	19	of	of	IN
cord-016293-pyb00pt5	835	20	a	a	DT
cord-016293-pyb00pt5	835	21	complex	complex	JJ
cord-016293-pyb00pt5	835	22	disease	disease	NN
cord-016293-pyb00pt5	835	23	and/or	and/or	CC
cord-016293-pyb00pt5	835	24	treatment	treatment	NN
cord-016293-pyb00pt5	835	25	response	response	NN
cord-016293-pyb00pt5	835	26	.	.	.
cord-016293-pyb00pt5	836	1	So	so	RB
cord-016293-pyb00pt5	836	2	,	,	,
cord-016293-pyb00pt5	836	3	while	while	IN
cord-016293-pyb00pt5	836	4	a	a	DT
cord-016293-pyb00pt5	836	5	single	single	JJ
cord-016293-pyb00pt5	836	6	genetic	genetic	JJ
cord-016293-pyb00pt5	836	7	risk	risk	NN
cord-016293-pyb00pt5	836	8	factor	factor	NN
cord-016293-pyb00pt5	836	9	is	be	VBZ
cord-016293-pyb00pt5	836	10	not	not	RB
cord-016293-pyb00pt5	836	11	a	a	DT
cord-016293-pyb00pt5	836	12	good	good	JJ
cord-016293-pyb00pt5	836	13	predictor	predictor	NN
cord-016293-pyb00pt5	836	14	of	of	IN
cord-016293-pyb00pt5	836	15	treatment	treatment	NN
cord-016293-pyb00pt5	836	16	outcome	outcome	NN
cord-016293-pyb00pt5	836	17	,	,	,
cord-016293-pyb00pt5	836	18	the	the	DT
cord-016293-pyb00pt5	836	19	sum	sum	NN
cord-016293-pyb00pt5	836	20	of	of	IN
cord-016293-pyb00pt5	836	21	a	a	DT
cord-016293-pyb00pt5	836	22	large	large	JJ
cord-016293-pyb00pt5	836	23	fraction	fraction	NN
cord-016293-pyb00pt5	836	24	of	of	IN
cord-016293-pyb00pt5	836	25	risk	risk	NN
cord-016293-pyb00pt5	836	26	factors	factor	NNS
cord-016293-pyb00pt5	836	27	contributing	contribute	VBG
cord-016293-pyb00pt5	836	28	to	to	IN
cord-016293-pyb00pt5	836	29	a	a	DT
cord-016293-pyb00pt5	836	30	treatment	treatment	NN
cord-016293-pyb00pt5	836	31	response	response	NN
cord-016293-pyb00pt5	836	32	or	or	CC
cord-016293-pyb00pt5	836	33	common	common	JJ
cord-016293-pyb00pt5	836	34	disease	disease	NN
cord-016293-pyb00pt5	836	35	can	can	MD
cord-016293-pyb00pt5	836	36	be	be	VB
cord-016293-pyb00pt5	836	37	used	use	VBN
cord-016293-pyb00pt5	836	38	to	to	TO
cord-016293-pyb00pt5	836	39	optimize	optimize	VB
cord-016293-pyb00pt5	836	40	personalized	personalized	JJ
cord-016293-pyb00pt5	836	41	treatments	treatment	NNS
cord-016293-pyb00pt5	836	42	without	without	IN
cord-016293-pyb00pt5	836	43	requiring	require	VBG
cord-016293-pyb00pt5	836	44	knowledge	knowledge	NN
cord-016293-pyb00pt5	836	45	of	of	IN
cord-016293-pyb00pt5	836	46	the	the	DT
cord-016293-pyb00pt5	836	47	underlying	underlie	VBG
cord-016293-pyb00pt5	836	48	mechanisms	mechanism	NNS
cord-016293-pyb00pt5	836	49	of	of	IN
cord-016293-pyb00pt5	836	50	the	the	DT
cord-016293-pyb00pt5	836	51	disease	disease	NN
cord-016293-pyb00pt5	836	52	.	.	.
cord-016293-pyb00pt5	837	1	They	-PRON-	PRP
cord-016293-pyb00pt5	837	2	feel	feel	VBP
cord-016293-pyb00pt5	837	3	that	that	IN
cord-016293-pyb00pt5	837	4	a	a	DT
cord-016293-pyb00pt5	837	5	saturating	saturate	VBG
cord-016293-pyb00pt5	837	6	level	level	NN
cord-016293-pyb00pt5	837	7	of	of	IN
cord-016293-pyb00pt5	837	8	coverage	coverage	NN
cord-016293-pyb00pt5	837	9	is	be	VBZ
cord-016293-pyb00pt5	837	10	required	require	VBN
cord-016293-pyb00pt5	837	11	to	to	TO
cord-016293-pyb00pt5	837	12	produce	produce	VB
cord-016293-pyb00pt5	837	13	repeatable	repeatable	JJ
cord-016293-pyb00pt5	837	14	prediction	prediction	NN
cord-016293-pyb00pt5	837	15	of	of	IN
cord-016293-pyb00pt5	837	16	response	response	NN
cord-016293-pyb00pt5	837	17	to	to	IN
cord-016293-pyb00pt5	837	18	medication	medication	NN
cord-016293-pyb00pt5	837	19	or	or	CC
cord-016293-pyb00pt5	837	20	predisposition	predisposition	NN
cord-016293-pyb00pt5	837	21	to	to	IN
cord-016293-pyb00pt5	837	22	disease	disease	NN
cord-016293-pyb00pt5	837	23	and	and	CC
cord-016293-pyb00pt5	837	24	that	that	IN
cord-016293-pyb00pt5	837	25	taking	take	VBG
cord-016293-pyb00pt5	837	26	shortcuts	shortcut	NNS
cord-016293-pyb00pt5	837	27	will	will	MD
cord-016293-pyb00pt5	837	28	for	for	IN
cord-016293-pyb00pt5	837	29	the	the	DT
cord-016293-pyb00pt5	837	30	most	most	JJS
cord-016293-pyb00pt5	837	31	part	part	NN
cord-016293-pyb00pt5	837	32	lead	lead	VB
cord-016293-pyb00pt5	837	33	to	to	IN
cord-016293-pyb00pt5	837	34	incomplete	incomplete	JJ
cord-016293-pyb00pt5	837	35	,	,	,
cord-016293-pyb00pt5	837	36	clinically	clinically	RB
cord-016293-pyb00pt5	837	37	-	-	HYPH
cord-016293-pyb00pt5	837	38	irrelevant	irrelevant	JJ
cord-016293-pyb00pt5	837	39	results	result	NNS
cord-016293-pyb00pt5	837	40	.	.	.
cord-016293-pyb00pt5	838	1	In	in	IN
cord-016293-pyb00pt5	838	2	2005	2005	CD
cord-016293-pyb00pt5	838	3	Hinds	Hinds	NNP
cord-016293-pyb00pt5	838	4	et	et	NNP
cord-016293-pyb00pt5	838	5	al	al	NNP
cord-016293-pyb00pt5	838	6	.	.	.
cord-016293-pyb00pt5	839	1	in	in	IN
cord-016293-pyb00pt5	839	2	Science	Science	NNP
cord-016293-pyb00pt5	839	3	describe	describe	VBP
cord-016293-pyb00pt5	839	4	even	even	RB
cord-016293-pyb00pt5	839	5	more	more	RBR
cord-016293-pyb00pt5	839	6	dramatic	dramatic	JJ
cord-016293-pyb00pt5	839	7	progresss	progress	NNS
cord-016293-pyb00pt5	839	8	.	.	.
cord-016293-pyb00pt5	840	1	They	-PRON-	PRP
cord-016293-pyb00pt5	840	2	describe	describe	VBP
cord-016293-pyb00pt5	840	3	a	a	DT
cord-016293-pyb00pt5	840	4	publicly	publicly	RB
cord-016293-pyb00pt5	840	5	available	available	JJ
cord-016293-pyb00pt5	840	6	,	,	,
cord-016293-pyb00pt5	840	7	genome	genome	NN
cord-016293-pyb00pt5	840	8	-	-	HYPH
cord-016293-pyb00pt5	840	9	wide	wide	JJ
cord-016293-pyb00pt5	840	10	data	datum	NNS
cord-016293-pyb00pt5	840	11	set	set	VBN
cord-016293-pyb00pt5	840	12	of	of	IN
cord-016293-pyb00pt5	840	13	1.58	1.58	CD
cord-016293-pyb00pt5	840	14	million	million	CD
cord-016293-pyb00pt5	840	15	common	common	JJ
cord-016293-pyb00pt5	840	16	singlenucleotide	singlenucleotide	NN
cord-016293-pyb00pt5	840	17	polymorphisms	polymorphism	NNS
cord-016293-pyb00pt5	840	18	(	(	-LRB-
cord-016293-pyb00pt5	840	19	SNPs	SNPs	NNP
cord-016293-pyb00pt5	840	20	)	)	-RRB-
cord-016293-pyb00pt5	840	21	that	that	WDT
cord-016293-pyb00pt5	840	22	have	have	VBP
cord-016293-pyb00pt5	840	23	been	be	VBN
cord-016293-pyb00pt5	840	24	accurately	accurately	RB
cord-016293-pyb00pt5	840	25	genotyped	genotype	VBN
cord-016293-pyb00pt5	840	26	in	in	IN
cord-016293-pyb00pt5	840	27	each	each	DT
cord-016293-pyb00pt5	840	28	of	of	IN
cord-016293-pyb00pt5	840	29	71	71	CD
cord-016293-pyb00pt5	840	30	people	people	NNS
cord-016293-pyb00pt5	840	31	from	from	IN
cord-016293-pyb00pt5	840	32	three	three	CD
cord-016293-pyb00pt5	840	33	population	population	NN
cord-016293-pyb00pt5	840	34	samples	sample	NNS
cord-016293-pyb00pt5	840	35	.	.	.
cord-016293-pyb00pt5	841	1	A	a	DT
cord-016293-pyb00pt5	841	2	second	second	JJ
cord-016293-pyb00pt5	841	3	public	public	JJ
cord-016293-pyb00pt5	841	4	data	data	NN
cord-016293-pyb00pt5	841	5	set	set	VBN
cord-016293-pyb00pt5	841	6	of	of	IN
cord-016293-pyb00pt5	841	7	more	more	JJR
cord-016293-pyb00pt5	841	8	than	than	IN
cord-016293-pyb00pt5	841	9	1	1	CD
cord-016293-pyb00pt5	841	10	million	million	CD
cord-016293-pyb00pt5	841	11	SNPs	SNPs	NNPS
cord-016293-pyb00pt5	841	12	typed	type	VBN
cord-016293-pyb00pt5	841	13	in	in	IN
cord-016293-pyb00pt5	841	14	each	each	DT
cord-016293-pyb00pt5	841	15	of	of	IN
cord-016293-pyb00pt5	841	16	270	270	CD
cord-016293-pyb00pt5	841	17	people	people	NNS
cord-016293-pyb00pt5	841	18	has	have	VBZ
cord-016293-pyb00pt5	841	19	been	be	VBN
cord-016293-pyb00pt5	841	20	generated	generate	VBN
cord-016293-pyb00pt5	841	21	by	by	IN
cord-016293-pyb00pt5	841	22	the	the	DT
cord-016293-pyb00pt5	841	23	International	International	NNP
cord-016293-pyb00pt5	841	24	Haplotype	Haplotype	NNP
cord-016293-pyb00pt5	841	25	Map	Map	NNP
cord-016293-pyb00pt5	841	26	(	(	-LRB-
cord-016293-pyb00pt5	841	27	HapMap	HapMap	NNP
cord-016293-pyb00pt5	841	28	)	)	-RRB-
cord-016293-pyb00pt5	841	29	Project	Project	NNP
cord-016293-pyb00pt5	841	30	.	.	.
cord-016293-pyb00pt5	842	1	These	these	DT
cord-016293-pyb00pt5	842	2	two	two	CD
cord-016293-pyb00pt5	842	3	public	public	JJ
cord-016293-pyb00pt5	842	4	data	data	NN
cord-016293-pyb00pt5	842	5	sets	set	NNS
cord-016293-pyb00pt5	842	6	,	,	,
cord-016293-pyb00pt5	842	7	combined	combine	VBN
cord-016293-pyb00pt5	842	8	with	with	IN
cord-016293-pyb00pt5	842	9	multiple	multiple	JJ
cord-016293-pyb00pt5	842	10	new	new	JJ
cord-016293-pyb00pt5	842	11	technologies	technology	NNS
cord-016293-pyb00pt5	842	12	for	for	IN
cord-016293-pyb00pt5	842	13	rapid	rapid	JJ
cord-016293-pyb00pt5	842	14	and	and	CC
cord-016293-pyb00pt5	842	15	inexpensive	inexpensive	JJ
cord-016293-pyb00pt5	842	16	SNP	SNP	NNP
cord-016293-pyb00pt5	842	17	genotyping	genotyping	NN
cord-016293-pyb00pt5	842	18	,	,	,
cord-016293-pyb00pt5	842	19	are	be	VBP
cord-016293-pyb00pt5	842	20	paving	pave	VBG
cord-016293-pyb00pt5	842	21	the	the	DT
cord-016293-pyb00pt5	842	22	way	way	NN
cord-016293-pyb00pt5	842	23	for	for	IN
cord-016293-pyb00pt5	842	24	comprehensive	comprehensive	NNP
cord-016293-pyb00pt5	842	25	association	association	NN
cord-016293-pyb00pt5	842	26	studies	study	NNS
cord-016293-pyb00pt5	842	27	involving	involve	VBG
cord-016293-pyb00pt5	842	28	common	common	JJ
cord-016293-pyb00pt5	842	29	human	human	JJ
cord-016293-pyb00pt5	842	30	genetic	genetic	JJ
cord-016293-pyb00pt5	842	31	variations	variation	NNS
cord-016293-pyb00pt5	842	32	.	.	.
cord-016293-pyb00pt5	843	1	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	843	2	basically	basically	RB
cord-016293-pyb00pt5	843	3	is	be	VBZ
cord-016293-pyb00pt5	843	4	taking	take	VBG
cord-016293-pyb00pt5	843	5	to	to	IN
cord-016293-pyb00pt5	843	6	the	the	DT
cord-016293-pyb00pt5	843	7	next	next	JJ
cord-016293-pyb00pt5	843	8	level	level	NN
cord-016293-pyb00pt5	843	9	Fodor	Fodor	NNP
cord-016293-pyb00pt5	843	10	's	's	POS
cord-016293-pyb00pt5	843	11	stated	state	VBN
cord-016293-pyb00pt5	843	12	reason	reason	NN
cord-016293-pyb00pt5	843	13	for	for	IN
cord-016293-pyb00pt5	843	14	the	the	DT
cord-016293-pyb00pt5	843	15	creation	creation	NN
cord-016293-pyb00pt5	843	16	of	of	IN
cord-016293-pyb00pt5	843	17	Affymetrix	Affymetrix	NNP
cord-016293-pyb00pt5	843	18	,	,	,
cord-016293-pyb00pt5	843	19	the	the	DT
cord-016293-pyb00pt5	843	20	belief	belief	NN
cord-016293-pyb00pt5	843	21	that	that	IN
cord-016293-pyb00pt5	843	22	understanding	understand	VBG
cord-016293-pyb00pt5	843	23	the	the	DT
cord-016293-pyb00pt5	843	24	correlation	correlation	NN
cord-016293-pyb00pt5	843	25	between	between	IN
cord-016293-pyb00pt5	843	26	genetic	genetic	JJ
cord-016293-pyb00pt5	843	27	variability	variability	NN
cord-016293-pyb00pt5	843	28	and	and	CC
cord-016293-pyb00pt5	843	29	its	-PRON-	PRP$
cord-016293-pyb00pt5	843	30	role	role	NN
cord-016293-pyb00pt5	843	31	in	in	IN
cord-016293-pyb00pt5	843	32	health	health	NN
cord-016293-pyb00pt5	843	33	and	and	CC
cord-016293-pyb00pt5	843	34	disease	disease	NN
cord-016293-pyb00pt5	843	35	would	would	MD
cord-016293-pyb00pt5	843	36	be	be	VB
cord-016293-pyb00pt5	843	37	the	the	DT
cord-016293-pyb00pt5	843	38	next	next	JJ
cord-016293-pyb00pt5	843	39	step	step	NN
cord-016293-pyb00pt5	843	40	in	in	IN
cord-016293-pyb00pt5	843	41	the	the	DT
cord-016293-pyb00pt5	843	42	genomics	genomic	NNS
cord-016293-pyb00pt5	843	43	revolution	revolution	NN
cord-016293-pyb00pt5	843	44	.	.	.
cord-016293-pyb00pt5	844	1	The	the	DT
cord-016293-pyb00pt5	844	2	other	other	JJ
cord-016293-pyb00pt5	844	3	interesting	interesting	JJ
cord-016293-pyb00pt5	844	4	aspect	aspect	NN
cord-016293-pyb00pt5	844	5	of	of	IN
cord-016293-pyb00pt5	844	6	this	this	DT
cord-016293-pyb00pt5	844	7	level	level	NN
cord-016293-pyb00pt5	844	8	of	of	IN
cord-016293-pyb00pt5	844	9	coverage	coverage	NN
cord-016293-pyb00pt5	844	10	is	be	VBZ
cord-016293-pyb00pt5	844	11	,	,	,
cord-016293-pyb00pt5	844	12	of	of	IN
cord-016293-pyb00pt5	844	13	course	course	NN
cord-016293-pyb00pt5	844	14	,	,	,
cord-016293-pyb00pt5	844	15	the	the	DT
cord-016293-pyb00pt5	844	16	notion	notion	NN
cord-016293-pyb00pt5	844	17	of	of	IN
cord-016293-pyb00pt5	844	18	discrete	discrete	JJ
cord-016293-pyb00pt5	844	19	identifiable	identifiable	JJ
cord-016293-pyb00pt5	844	20	groups	group	NNS
cord-016293-pyb00pt5	844	21	based	base	VBN
cord-016293-pyb00pt5	844	22	on	on	IN
cord-016293-pyb00pt5	844	23	ethnicity	ethnicity	NN
cord-016293-pyb00pt5	844	24	,	,	,
cord-016293-pyb00pt5	844	25	centers	center	NNS
cord-016293-pyb00pt5	844	26	of	of	IN
cord-016293-pyb00pt5	844	27	origin	origin	NN
cord-016293-pyb00pt5	844	28	and	and	CC
cord-016293-pyb00pt5	844	29	such	such	JJ
cord-016293-pyb00pt5	844	30	breaks	break	NNS
cord-016293-pyb00pt5	844	31	down	down	RP
cord-016293-pyb00pt5	844	32	and	and	CC
cord-016293-pyb00pt5	844	33	a	a	DT
cord-016293-pyb00pt5	844	34	spectrum	spectrum	NN
cord-016293-pyb00pt5	844	35	of	of	IN
cord-016293-pyb00pt5	844	36	variation	variation	NN
cord-016293-pyb00pt5	844	37	arises	arise	VBZ
cord-016293-pyb00pt5	844	38	across	across	IN
cord-016293-pyb00pt5	844	39	all	all	DT
cord-016293-pyb00pt5	844	40	populations	population	NNS
cord-016293-pyb00pt5	844	41	which	which	WDT
cord-016293-pyb00pt5	844	42	makes	make	VBZ
cord-016293-pyb00pt5	844	43	the	the	DT
cord-016293-pyb00pt5	844	44	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	844	45	chip	chip	NN
cord-016293-pyb00pt5	844	46	,	,	,
cord-016293-pyb00pt5	844	47	at	at	IN
cord-016293-pyb00pt5	844	48	one	one	CD
cord-016293-pyb00pt5	844	49	level	level	NN
cord-016293-pyb00pt5	844	50	,	,	,
cord-016293-pyb00pt5	844	51	a	a	DT
cord-016293-pyb00pt5	844	52	true	true	JJ
cord-016293-pyb00pt5	844	53	unifier	unifier	NN
cord-016293-pyb00pt5	844	54	of	of	IN
cord-016293-pyb00pt5	844	55	humanity	humanity	NN
cord-016293-pyb00pt5	844	56	but	but	CC
cord-016293-pyb00pt5	844	57	at	at	IN
cord-016293-pyb00pt5	844	58	another	another	DT
cord-016293-pyb00pt5	844	59	adds	add	VBZ
cord-016293-pyb00pt5	844	60	a	a	DT
cord-016293-pyb00pt5	844	61	whole	whole	JJ
cord-016293-pyb00pt5	844	62	layer	layer	NN
cord-016293-pyb00pt5	844	63	of	of	IN
cord-016293-pyb00pt5	844	64	complexity	complexity	NN
cord-016293-pyb00pt5	844	65	for	for	IN
cord-016293-pyb00pt5	844	66	HMOs	hmo	NNS
cord-016293-pyb00pt5	844	67	!	!	.
cord-016293-pyb00pt5	845	1	At	at	IN
cord-016293-pyb00pt5	845	2	the	the	DT
cord-016293-pyb00pt5	845	3	turn	turn	NN
cord-016293-pyb00pt5	845	4	of	of	IN
cord-016293-pyb00pt5	845	5	the	the	DT
cord-016293-pyb00pt5	845	6	century	century	NN
cord-016293-pyb00pt5	845	7	,	,	,
cord-016293-pyb00pt5	845	8	this	this	DT
cord-016293-pyb00pt5	845	9	personalized	personalized	JJ
cord-016293-pyb00pt5	845	10	chip	chip	NN
cord-016293-pyb00pt5	845	11	approach	approach	NN
cord-016293-pyb00pt5	845	12	to	to	IN
cord-016293-pyb00pt5	845	13	medicine	medicine	NN
cord-016293-pyb00pt5	845	14	received	receive	VBD
cord-016293-pyb00pt5	845	15	some	some	DT
cord-016293-pyb00pt5	845	16	validation	validation	NN
cord-016293-pyb00pt5	845	17	at	at	IN
cord-016293-pyb00pt5	845	18	a	a	DT
cord-016293-pyb00pt5	845	19	simpler	simple	JJR
cord-016293-pyb00pt5	845	20	level	level	NN
cord-016293-pyb00pt5	845	21	in	in	IN
cord-016293-pyb00pt5	845	22	a	a	DT
cord-016293-pyb00pt5	845	23	closely	closely	RB
cord-016293-pyb00pt5	845	24	related	related	JJ
cord-016293-pyb00pt5	845	25	disease	disease	NN
cord-016293-pyb00pt5	845	26	area	area	NN
cord-016293-pyb00pt5	845	27	to	to	IN
cord-016293-pyb00pt5	845	28	the	the	DT
cord-016293-pyb00pt5	845	29	one	one	NN
cord-016293-pyb00pt5	845	30	to	to	TO
cord-016293-pyb00pt5	845	31	which	which	WDT
cord-016293-pyb00pt5	845	32	one	one	CD
cord-016293-pyb00pt5	845	33	fifth	fifth	NN
cord-016293-pyb00pt5	845	34	of	of	IN
cord-016293-pyb00pt5	845	35	A	A	NNP
cord-016293-pyb00pt5	845	36	-	-	HYPH
cord-016293-pyb00pt5	845	37	T	t	NN
cord-016293-pyb00pt5	845	38	patients	patient	NNS
cord-016293-pyb00pt5	845	39	ultimately	ultimately	RB
cord-016293-pyb00pt5	845	40	succumb	succumb	VBP
cord-016293-pyb00pt5	845	41	when	when	WRB
cord-016293-pyb00pt5	845	42	researchers	researcher	NNS
cord-016293-pyb00pt5	845	43	at	at	IN
cord-016293-pyb00pt5	845	44	the	the	DT
cord-016293-pyb00pt5	845	45	Whitehead	Whitehead	NNP
cord-016293-pyb00pt5	845	46	Institute	Institute	NNP
cord-016293-pyb00pt5	845	47	used	use	VBD
cord-016293-pyb00pt5	845	48	DNA	dna	NN
cord-016293-pyb00pt5	845	49	chips	chip	NNS
cord-016293-pyb00pt5	845	50	to	to	TO
cord-016293-pyb00pt5	845	51	distinguish	distinguish	VB
cord-016293-pyb00pt5	845	52	different	different	JJ
cord-016293-pyb00pt5	845	53	forms	form	NNS
cord-016293-pyb00pt5	845	54	of	of	IN
cord-016293-pyb00pt5	845	55	leukemia	leukemia	NN
cord-016293-pyb00pt5	845	56	based	base	VBN
cord-016293-pyb00pt5	845	57	on	on	IN
cord-016293-pyb00pt5	845	58	patterns	pattern	NNS
cord-016293-pyb00pt5	845	59	of	of	IN
cord-016293-pyb00pt5	845	60	gene	gene	NN
cord-016293-pyb00pt5	845	61	expression	expression	NN
cord-016293-pyb00pt5	845	62	in	in	IN
cord-016293-pyb00pt5	845	63	different	different	JJ
cord-016293-pyb00pt5	845	64	populations	population	NNS
cord-016293-pyb00pt5	845	65	of	of	IN
cord-016293-pyb00pt5	845	66	cells	cell	NNS
cord-016293-pyb00pt5	845	67	.	.	.
cord-016293-pyb00pt5	846	1	Moving	move	VBG
cord-016293-pyb00pt5	846	2	cancer	cancer	NN
cord-016293-pyb00pt5	846	3	diagnosis	diagnosis	NN
cord-016293-pyb00pt5	846	4	away	away	RB
cord-016293-pyb00pt5	846	5	from	from	IN
cord-016293-pyb00pt5	846	6	visually	visually	RB
cord-016293-pyb00pt5	846	7	based	base	VBN
cord-016293-pyb00pt5	846	8	systems	system	NNS
cord-016293-pyb00pt5	846	9	to	to	IN
cord-016293-pyb00pt5	846	10	such	such	JJ
cord-016293-pyb00pt5	846	11	molecular	molecular	JJ
cord-016293-pyb00pt5	846	12	based	base	VBN
cord-016293-pyb00pt5	846	13	systems	system	NNS
cord-016293-pyb00pt5	846	14	is	be	VBZ
cord-016293-pyb00pt5	846	15	a	a	DT
cord-016293-pyb00pt5	846	16	major	major	JJ
cord-016293-pyb00pt5	846	17	goal	goal	NN
cord-016293-pyb00pt5	846	18	of	of	IN
cord-016293-pyb00pt5	846	19	the	the	DT
cord-016293-pyb00pt5	846	20	National	National	NNP
cord-016293-pyb00pt5	846	21	Cancer	Cancer	NNP
cord-016293-pyb00pt5	846	22	Institute	Institute	NNP
cord-016293-pyb00pt5	846	23	.	.	.
cord-016293-pyb00pt5	847	1	In	in	IN
cord-016293-pyb00pt5	847	2	the	the	DT
cord-016293-pyb00pt5	847	3	study	study	NN
cord-016293-pyb00pt5	847	4	,	,	,
cord-016293-pyb00pt5	847	5	scientists	scientist	NNS
cord-016293-pyb00pt5	847	6	used	use	VBD
cord-016293-pyb00pt5	847	7	a	a	DT
cord-016293-pyb00pt5	847	8	DNA	dna	NN
cord-016293-pyb00pt5	847	9	chip	chip	NN
cord-016293-pyb00pt5	847	10	to	to	TO
cord-016293-pyb00pt5	847	11	examine	examine	VB
cord-016293-pyb00pt5	847	12	gene	gene	NN
cord-016293-pyb00pt5	847	13	activity	activity	NN
cord-016293-pyb00pt5	847	14	in	in	IN
cord-016293-pyb00pt5	847	15	bone	bone	NN
cord-016293-pyb00pt5	847	16	marrow	marrow	NN
cord-016293-pyb00pt5	847	17	samples	sample	NNS
cord-016293-pyb00pt5	847	18	from	from	IN
cord-016293-pyb00pt5	847	19	patients	patient	NNS
cord-016293-pyb00pt5	847	20	with	with	IN
cord-016293-pyb00pt5	847	21	two	two	CD
cord-016293-pyb00pt5	847	22	different	different	JJ
cord-016293-pyb00pt5	847	23	types	type	NNS
cord-016293-pyb00pt5	847	24	of	of	IN
cord-016293-pyb00pt5	847	25	acute	acute	JJ
cord-016293-pyb00pt5	847	26	leukemia	leukemia	NN
cord-016293-pyb00pt5	847	27	-acute	-acute	CD
cord-016293-pyb00pt5	847	28	myeloid	myeloid	NN
cord-016293-pyb00pt5	847	29	leukemia	leukemia	NN
cord-016293-pyb00pt5	847	30	(	(	-LRB-
cord-016293-pyb00pt5	847	31	AML	AML	NNP
cord-016293-pyb00pt5	847	32	)	)	-RRB-
cord-016293-pyb00pt5	847	33	and	and	CC
cord-016293-pyb00pt5	847	34	acute	acute	JJ
cord-016293-pyb00pt5	847	35	lymphoblastic	lymphoblastic	JJ
cord-016293-pyb00pt5	847	36	leukemia	leukemia	NN
cord-016293-pyb00pt5	847	37	(	(	-LRB-
cord-016293-pyb00pt5	847	38	ALL	all	DT
cord-016293-pyb00pt5	847	39	)	)	-RRB-
cord-016293-pyb00pt5	847	40	.	.	.
cord-016293-pyb00pt5	848	1	Then	then	RB
cord-016293-pyb00pt5	848	2	,	,	,
cord-016293-pyb00pt5	848	3	using	use	VBG
cord-016293-pyb00pt5	848	4	an	an	DT
cord-016293-pyb00pt5	848	5	algorithm	algorithm	NN
cord-016293-pyb00pt5	848	6	,	,	,
cord-016293-pyb00pt5	848	7	developed	develop	VBN
cord-016293-pyb00pt5	848	8	at	at	IN
cord-016293-pyb00pt5	848	9	the	the	DT
cord-016293-pyb00pt5	848	10	Whitehead	Whitehead	NNP
cord-016293-pyb00pt5	848	11	,	,	,
cord-016293-pyb00pt5	848	12	they	-PRON-	PRP
cord-016293-pyb00pt5	848	13	identified	identify	VBD
cord-016293-pyb00pt5	848	14	signature	signature	NN
cord-016293-pyb00pt5	848	15	patterns	pattern	NNS
cord-016293-pyb00pt5	848	16	that	that	WDT
cord-016293-pyb00pt5	848	17	could	could	MD
cord-016293-pyb00pt5	848	18	distinguish	distinguish	VB
cord-016293-pyb00pt5	848	19	the	the	DT
cord-016293-pyb00pt5	848	20	two	two	CD
cord-016293-pyb00pt5	848	21	types	type	NNS
cord-016293-pyb00pt5	848	22	.	.	.
cord-016293-pyb00pt5	849	1	When	when	WRB
cord-016293-pyb00pt5	849	2	they	-PRON-	PRP
cord-016293-pyb00pt5	849	3	cross	cross	VBP
cord-016293-pyb00pt5	849	4	-	-	VBD
cord-016293-pyb00pt5	849	5	checked	check	VBD
cord-016293-pyb00pt5	849	6	the	the	DT
cord-016293-pyb00pt5	849	7	diagnoses	diagnosis	NNS
cord-016293-pyb00pt5	849	8	made	make	VBN
cord-016293-pyb00pt5	849	9	by	by	IN
cord-016293-pyb00pt5	849	10	the	the	DT
cord-016293-pyb00pt5	849	11	chip	chip	NN
cord-016293-pyb00pt5	849	12	against	against	IN
cord-016293-pyb00pt5	849	13	known	know	VBN
cord-016293-pyb00pt5	849	14	differences	difference	NNS
cord-016293-pyb00pt5	849	15	in	in	IN
cord-016293-pyb00pt5	849	16	the	the	DT
cord-016293-pyb00pt5	849	17	two	two	CD
cord-016293-pyb00pt5	849	18	types	type	NNS
cord-016293-pyb00pt5	849	19	of	of	IN
cord-016293-pyb00pt5	849	20	leukemia	leukemia	NN
cord-016293-pyb00pt5	849	21	,	,	,
cord-016293-pyb00pt5	849	22	they	-PRON-	PRP
cord-016293-pyb00pt5	849	23	found	find	VBD
cord-016293-pyb00pt5	849	24	that	that	IN
cord-016293-pyb00pt5	849	25	the	the	DT
cord-016293-pyb00pt5	849	26	chip	chip	NN
cord-016293-pyb00pt5	849	27	method	method	NN
cord-016293-pyb00pt5	849	28	could	could	MD
cord-016293-pyb00pt5	849	29	automatically	automatically	RB
cord-016293-pyb00pt5	849	30	make	make	VB
cord-016293-pyb00pt5	849	31	the	the	DT
cord-016293-pyb00pt5	849	32	distinction	distinction	NN
cord-016293-pyb00pt5	849	33	between	between	IN
cord-016293-pyb00pt5	849	34	AML	AML	NNP
cord-016293-pyb00pt5	849	35	and	and	CC
cord-016293-pyb00pt5	849	36	ALL	all	DT
cord-016293-pyb00pt5	849	37	without	without	IN
cord-016293-pyb00pt5	849	38	previous	previous	JJ
cord-016293-pyb00pt5	849	39	knowledge	knowledge	NN
cord-016293-pyb00pt5	849	40	of	of	IN
cord-016293-pyb00pt5	849	41	these	these	DT
cord-016293-pyb00pt5	849	42	classes	class	NNS
cord-016293-pyb00pt5	849	43	.	.	.
cord-016293-pyb00pt5	850	1	Taking	take	VBG
cord-016293-pyb00pt5	850	2	it	-PRON-	PRP
cord-016293-pyb00pt5	850	3	to	to	IN
cord-016293-pyb00pt5	850	4	a	a	DT
cord-016293-pyb00pt5	850	5	level	level	NN
cord-016293-pyb00pt5	850	6	beyond	beyond	IN
cord-016293-pyb00pt5	850	7	where	where	WRB
cord-016293-pyb00pt5	850	8	Perlegen	Perlegen	NNP
cord-016293-pyb00pt5	850	9	are	be	VBP
cord-016293-pyb00pt5	850	10	initially	initially	RB
cord-016293-pyb00pt5	850	11	aiming	aim	VBG
cord-016293-pyb00pt5	850	12	,	,	,
cord-016293-pyb00pt5	850	13	Eric	Eric	NNP
cord-016293-pyb00pt5	850	14	Lander	Lander	NNP
cord-016293-pyb00pt5	850	15	,	,	,
cord-016293-pyb00pt5	850	16	leader	leader	NN
cord-016293-pyb00pt5	850	17	of	of	IN
cord-016293-pyb00pt5	850	18	the	the	DT
cord-016293-pyb00pt5	850	19	study	study	NN
cord-016293-pyb00pt5	850	20	said	say	VBD
cord-016293-pyb00pt5	850	21	,	,	,
cord-016293-pyb00pt5	850	22	mapping	mapping	NN
cord-016293-pyb00pt5	850	23	not	not	RB
cord-016293-pyb00pt5	850	24	only	only	RB
cord-016293-pyb00pt5	850	25	what	what	WP
cord-016293-pyb00pt5	850	26	is	be	VBZ
cord-016293-pyb00pt5	850	27	in	in	IN
cord-016293-pyb00pt5	850	28	the	the	DT
cord-016293-pyb00pt5	850	29	genome	genome	NN
cord-016293-pyb00pt5	850	30	,	,	,
cord-016293-pyb00pt5	850	31	but	but	CC
cord-016293-pyb00pt5	850	32	also	also	RB
cord-016293-pyb00pt5	850	33	what	what	WP
cord-016293-pyb00pt5	850	34	the	the	DT
cord-016293-pyb00pt5	850	35	things	thing	NNS
cord-016293-pyb00pt5	850	36	in	in	IN
cord-016293-pyb00pt5	850	37	the	the	DT
cord-016293-pyb00pt5	850	38	genome	genome	NN
cord-016293-pyb00pt5	850	39	do	do	VBP
cord-016293-pyb00pt5	850	40	,	,	,
cord-016293-pyb00pt5	850	41	is	be	VBZ
cord-016293-pyb00pt5	850	42	the	the	DT
cord-016293-pyb00pt5	850	43	real	real	JJ
cord-016293-pyb00pt5	850	44	secret	secret	NN
cord-016293-pyb00pt5	850	45	to	to	IN
cord-016293-pyb00pt5	850	46	comprehending	comprehend	VBG
cord-016293-pyb00pt5	850	47	and	and	CC
cord-016293-pyb00pt5	850	48	ultimately	ultimately	RB
cord-016293-pyb00pt5	850	49	curing	cure	VBG
cord-016293-pyb00pt5	850	50	cancer	cancer	NN
cord-016293-pyb00pt5	850	51	and	and	CC
cord-016293-pyb00pt5	850	52	other	other	JJ
cord-016293-pyb00pt5	850	53	diseases	disease	NNS
cord-016293-pyb00pt5	850	54	.	.	.
cord-016293-pyb00pt5	851	1	Chips	chip	NNS
cord-016293-pyb00pt5	851	2	gained	gain	VBD
cord-016293-pyb00pt5	851	3	recognition	recognition	NN
cord-016293-pyb00pt5	851	4	on	on	IN
cord-016293-pyb00pt5	851	5	the	the	DT
cord-016293-pyb00pt5	851	6	world	world	NN
cord-016293-pyb00pt5	851	7	stage	stage	NN
cord-016293-pyb00pt5	851	8	in	in	IN
cord-016293-pyb00pt5	851	9	2003	2003	CD
cord-016293-pyb00pt5	851	10	when	when	WRB
cord-016293-pyb00pt5	851	11	they	-PRON-	PRP
cord-016293-pyb00pt5	851	12	played	play	VBD
cord-016293-pyb00pt5	851	13	a	a	DT
cord-016293-pyb00pt5	851	14	key	key	JJ
cord-016293-pyb00pt5	851	15	role	role	NN
cord-016293-pyb00pt5	851	16	in	in	IN
cord-016293-pyb00pt5	851	17	the	the	DT
cord-016293-pyb00pt5	851	18	search	search	NN
cord-016293-pyb00pt5	851	19	for	for	IN
cord-016293-pyb00pt5	851	20	the	the	DT
cord-016293-pyb00pt5	851	21	cause	cause	NN
cord-016293-pyb00pt5	851	22	of	of	IN
cord-016293-pyb00pt5	851	23	Severe	severe	JJ
cord-016293-pyb00pt5	851	24	Acute	acute	JJ
cord-016293-pyb00pt5	851	25	Respiratory	Respiratory	NNP
cord-016293-pyb00pt5	851	26	Syndrome	Syndrome	NNP
cord-016293-pyb00pt5	851	27	(	(	-LRB-
cord-016293-pyb00pt5	851	28	SARS	SARS	NNP
cord-016293-pyb00pt5	851	29	)	)	-RRB-
cord-016293-pyb00pt5	851	30	and	and	CC
cord-016293-pyb00pt5	851	31	probably	probably	RB
cord-016293-pyb00pt5	851	32	won	win	VBD
cord-016293-pyb00pt5	851	33	a	a	DT
cord-016293-pyb00pt5	851	34	McArthur	McArthur	NNP
cord-016293-pyb00pt5	851	35	genius	genius	NN
cord-016293-pyb00pt5	851	36	award	award	NN
cord-016293-pyb00pt5	851	37	for	for	IN
cord-016293-pyb00pt5	851	38	their	-PRON-	PRP$
cord-016293-pyb00pt5	851	39	creator	creator	NN
cord-016293-pyb00pt5	851	40	.	.	.
cord-016293-pyb00pt5	852	1	UCSF	UCSF	NNP
cord-016293-pyb00pt5	852	2	Assistant	Assistant	NNP
cord-016293-pyb00pt5	852	3	Professor	Professor	NNP
cord-016293-pyb00pt5	852	4	Joseph	Joseph	NNP
cord-016293-pyb00pt5	852	5	DeRisi	DeRisi	NNP
cord-016293-pyb00pt5	852	6	,	,	,
cord-016293-pyb00pt5	852	7	already	already	RB
cord-016293-pyb00pt5	852	8	famous	famous	JJ
cord-016293-pyb00pt5	852	9	in	in	IN
cord-016293-pyb00pt5	852	10	the	the	DT
cord-016293-pyb00pt5	852	11	scientific	scientific	JJ
cord-016293-pyb00pt5	852	12	community	community	NN
cord-016293-pyb00pt5	852	13	as	as	IN
cord-016293-pyb00pt5	852	14	the	the	DT
cord-016293-pyb00pt5	852	15	wunderkind	wunderkind	NN
cord-016293-pyb00pt5	852	16	originator	originator	NN
cord-016293-pyb00pt5	852	17	of	of	IN
cord-016293-pyb00pt5	852	18	the	the	DT
cord-016293-pyb00pt5	852	19	online	online	JJ
cord-016293-pyb00pt5	852	20	DIY	diy	NN
cord-016293-pyb00pt5	852	21	chip	chip	NN
cord-016293-pyb00pt5	852	22	maker	maker	NN
cord-016293-pyb00pt5	852	23	in	in	IN
cord-016293-pyb00pt5	852	24	Pat	Pat	NNP
cord-016293-pyb00pt5	852	25	Brown	Brown	NNP
cord-016293-pyb00pt5	852	26	's	's	POS
cord-016293-pyb00pt5	852	27	lab	lab	NN
cord-016293-pyb00pt5	852	28	at	at	IN
cord-016293-pyb00pt5	852	29	Stanford	Stanford	NNP
cord-016293-pyb00pt5	852	30	,	,	,
cord-016293-pyb00pt5	852	31	built	build	VBD
cord-016293-pyb00pt5	852	32	a	a	DT
cord-016293-pyb00pt5	852	33	gene	gene	NN
cord-016293-pyb00pt5	852	34	microarray	microarray	NN
cord-016293-pyb00pt5	852	35	containing	contain	VBG
cord-016293-pyb00pt5	852	36	all	all	DT
cord-016293-pyb00pt5	852	37	known	know	VBN
cord-016293-pyb00pt5	852	38	completely	completely	RB
cord-016293-pyb00pt5	852	39	sequenced	sequence	VBN
cord-016293-pyb00pt5	852	40	viruses	virus	NNS
cord-016293-pyb00pt5	852	41	(	(	-LRB-
cord-016293-pyb00pt5	852	42	12,000	12,000	CD
cord-016293-pyb00pt5	852	43	of	of	IN
cord-016293-pyb00pt5	852	44	them	-PRON-	PRP
cord-016293-pyb00pt5	852	45	)	)	-RRB-
cord-016293-pyb00pt5	852	46	and	and	CC
cord-016293-pyb00pt5	852	47	,	,	,
cord-016293-pyb00pt5	852	48	using	use	VBG
cord-016293-pyb00pt5	852	49	a	a	DT
cord-016293-pyb00pt5	852	50	robot	robot	NN
cord-016293-pyb00pt5	852	51	arm	arm	NN
cord-016293-pyb00pt5	852	52	that	that	WDT
cord-016293-pyb00pt5	852	53	he	-PRON-	PRP
cord-016293-pyb00pt5	852	54	also	also	RB
cord-016293-pyb00pt5	852	55	customized	customize	VBD
cord-016293-pyb00pt5	852	56	,	,	,
cord-016293-pyb00pt5	852	57	in	in	IN
cord-016293-pyb00pt5	852	58	a	a	DT
cord-016293-pyb00pt5	852	59	three	three	CD
cord-016293-pyb00pt5	852	60	day	day	NN
cord-016293-pyb00pt5	852	61	period	period	NN
cord-016293-pyb00pt5	852	62	used	use	VBD
cord-016293-pyb00pt5	852	63	it	-PRON-	PRP
cord-016293-pyb00pt5	852	64	to	to	TO
cord-016293-pyb00pt5	852	65	classify	classify	VB
cord-016293-pyb00pt5	852	66	a	a	DT
cord-016293-pyb00pt5	852	67	pathogen	pathogen	NN
cord-016293-pyb00pt5	852	68	isolated	isolate	VBN
cord-016293-pyb00pt5	852	69	from	from	IN
cord-016293-pyb00pt5	852	70	SARS	SARS	NNP
cord-016293-pyb00pt5	852	71	patients	patient	NNS
cord-016293-pyb00pt5	852	72	as	as	IN
cord-016293-pyb00pt5	852	73	a	a	DT
cord-016293-pyb00pt5	852	74	novel	novel	JJ
cord-016293-pyb00pt5	852	75	coronavirus	coronavirus	NN
cord-016293-pyb00pt5	852	76	.	.	.
cord-016293-pyb00pt5	853	1	When	when	WRB
cord-016293-pyb00pt5	853	2	a	a	DT
cord-016293-pyb00pt5	853	3	whole	whole	JJ
cord-016293-pyb00pt5	853	4	galaxy	galaxy	NN
cord-016293-pyb00pt5	853	5	of	of	IN
cord-016293-pyb00pt5	853	6	dots	dot	NNS
cord-016293-pyb00pt5	853	7	lit	light	VBN
cord-016293-pyb00pt5	853	8	up	up	RP
cord-016293-pyb00pt5	853	9	across	across	IN
cord-016293-pyb00pt5	853	10	the	the	DT
cord-016293-pyb00pt5	853	11	spectrum	spectrum	NN
cord-016293-pyb00pt5	853	12	of	of	IN
cord-016293-pyb00pt5	853	13	known	know	VBN
cord-016293-pyb00pt5	853	14	vertebrate	vertebrate	NN
cord-016293-pyb00pt5	853	15	cornoviruses	cornoviruse	NNS
cord-016293-pyb00pt5	854	1	DeRisis	DeRisis	NNP
cord-016293-pyb00pt5	854	2	knew	know	VBD
cord-016293-pyb00pt5	854	3	this	this	DT
cord-016293-pyb00pt5	854	4	was	be	VBD
cord-016293-pyb00pt5	854	5	a	a	DT
cord-016293-pyb00pt5	854	6	new	new	JJ
cord-016293-pyb00pt5	854	7	variant	variant	NN
cord-016293-pyb00pt5	854	8	.	.	.
cord-016293-pyb00pt5	855	1	Interestingly	interestingly	RB
cord-016293-pyb00pt5	855	2	the	the	DT
cord-016293-pyb00pt5	855	3	sequence	sequence	NN
cord-016293-pyb00pt5	855	4	had	have	VBD
cord-016293-pyb00pt5	855	5	the	the	DT
cord-016293-pyb00pt5	855	6	hottest	hot	JJS
cord-016293-pyb00pt5	855	7	signal	signal	NN
cord-016293-pyb00pt5	855	8	with	with	IN
cord-016293-pyb00pt5	855	9	Avian	avian	JJ
cord-016293-pyb00pt5	855	10	Infectious	Infectious	NNP
cord-016293-pyb00pt5	855	11	Bronchitis	Bronchitis	NNP
cord-016293-pyb00pt5	855	12	Virus	Virus	NNP
cord-016293-pyb00pt5	855	13	.	.	.
cord-016293-pyb00pt5	856	1	His	-PRON-	PRP$
cord-016293-pyb00pt5	856	2	work	work	NN
cord-016293-pyb00pt5	856	3	subsequently	subsequently	RB
cord-016293-pyb00pt5	856	4	led	lead	VBD
cord-016293-pyb00pt5	856	5	epidemiologists	epidemiologist	NNS
cord-016293-pyb00pt5	856	6	to	to	TO
cord-016293-pyb00pt5	856	7	target	target	VB
cord-016293-pyb00pt5	856	8	the	the	DT
cord-016293-pyb00pt5	856	9	masked	masked	JJ
cord-016293-pyb00pt5	856	10	palm	palm	NN
cord-016293-pyb00pt5	856	11	civet	civet	NN
cord-016293-pyb00pt5	856	12	,	,	,
cord-016293-pyb00pt5	856	13	a	a	DT
cord-016293-pyb00pt5	856	14	tree	tree	NN
cord-016293-pyb00pt5	856	15	-	-	HYPH
cord-016293-pyb00pt5	856	16	dwelling	dwell	VBG
cord-016293-pyb00pt5	856	17	animal	animal	NN
cord-016293-pyb00pt5	856	18	with	with	IN
cord-016293-pyb00pt5	856	19	a	a	DT
cord-016293-pyb00pt5	856	20	weasel	weasel	NN
cord-016293-pyb00pt5	856	21	-	-	HYPH
cord-016293-pyb00pt5	856	22	like	like	JJ
cord-016293-pyb00pt5	856	23	face	face	NN
cord-016293-pyb00pt5	856	24	and	and	CC
cord-016293-pyb00pt5	856	25	a	a	DT
cord-016293-pyb00pt5	856	26	catlike	catlike	JJ
cord-016293-pyb00pt5	856	27	body	body	NN
cord-016293-pyb00pt5	856	28	as	as	IN
cord-016293-pyb00pt5	856	29	the	the	DT
cord-016293-pyb00pt5	856	30	probable	probable	JJ
cord-016293-pyb00pt5	856	31	primary	primary	JJ
cord-016293-pyb00pt5	856	32	host	host	NN
cord-016293-pyb00pt5	856	33	.	.	.
cord-016293-pyb00pt5	857	1	The	the	DT
cord-016293-pyb00pt5	857	2	role	role	NN
cord-016293-pyb00pt5	857	3	that	that	WDT
cord-016293-pyb00pt5	857	4	DeRisi	DeRisi	NNP
cord-016293-pyb00pt5	857	5	's	's	POS
cord-016293-pyb00pt5	857	6	team	team	NN
cord-016293-pyb00pt5	857	7	at	at	IN
cord-016293-pyb00pt5	857	8	UCSF	UCSF	NNP
cord-016293-pyb00pt5	857	9	played	play	VBD
cord-016293-pyb00pt5	857	10	in	in	IN
cord-016293-pyb00pt5	857	11	identifying	identify	VBG
cord-016293-pyb00pt5	857	12	a	a	DT
cord-016293-pyb00pt5	857	13	coronavirus	coronavirus	NN
cord-016293-pyb00pt5	857	14	as	as	IN
cord-016293-pyb00pt5	857	15	a	a	DT
cord-016293-pyb00pt5	857	16	suspected	suspect	VBN
cord-016293-pyb00pt5	857	17	cause	cause	NN
cord-016293-pyb00pt5	857	18	of	of	IN
cord-016293-pyb00pt5	857	19	SARS	SARS	NNP
cord-016293-pyb00pt5	857	20	came	come	VBD
cord-016293-pyb00pt5	857	21	to	to	IN
cord-016293-pyb00pt5	857	22	the	the	DT
cord-016293-pyb00pt5	857	23	attention	attention	NN
cord-016293-pyb00pt5	857	24	of	of	IN
cord-016293-pyb00pt5	857	25	the	the	DT
cord-016293-pyb00pt5	857	26	national	national	JJ
cord-016293-pyb00pt5	857	27	media	medium	NNS
cord-016293-pyb00pt5	857	28	when	when	WRB
cord-016293-pyb00pt5	857	29	CDC	CDC	NNP
cord-016293-pyb00pt5	857	30	Director	Director	NNP
cord-016293-pyb00pt5	857	31	Dr.	Dr.	NNP
cord-016293-pyb00pt5	857	32	Julie	Julie	NNP
cord-016293-pyb00pt5	857	33	Gerberding	Gerberding	NNP
cord-016293-pyb00pt5	857	34	recognized	recognize	VBD
cord-016293-pyb00pt5	857	35	Joe	Joe	NNP
cord-016293-pyb00pt5	857	36	in	in	IN
cord-016293-pyb00pt5	857	37	March	March	NNP
cord-016293-pyb00pt5	857	38	24	24	CD
cord-016293-pyb00pt5	857	39	,	,	,
cord-016293-pyb00pt5	857	40	2003	2003	CD
cord-016293-pyb00pt5	857	41	press	press	NN
cord-016293-pyb00pt5	857	42	conference	conference	NN
cord-016293-pyb00pt5	857	43	and	and	CC
cord-016293-pyb00pt5	857	44	in	in	IN
cord-016293-pyb00pt5	857	45	2004	2004	CD
cord-016293-pyb00pt5	857	46	when	when	WRB
cord-016293-pyb00pt5	857	47	Joe	Joe	NNP
cord-016293-pyb00pt5	857	48	was	be	VBD
cord-016293-pyb00pt5	857	49	honored	honor	VBN
cord-016293-pyb00pt5	857	50	with	with	IN
cord-016293-pyb00pt5	857	51	one	one	CD
cord-016293-pyb00pt5	857	52	of	of	IN
cord-016293-pyb00pt5	857	53	the	the	DT
cord-016293-pyb00pt5	857	54	coveted	coveted	JJ
cord-016293-pyb00pt5	857	55	McArthur	McArthur	NNP
cord-016293-pyb00pt5	857	56	genius	genius	NN
cord-016293-pyb00pt5	857	57	awards	award	NNS
cord-016293-pyb00pt5	857	58	.	.	.
cord-016293-pyb00pt5	858	1	This	this	DT
cord-016293-pyb00pt5	858	2	and	and	CC
cord-016293-pyb00pt5	858	3	other	other	JJ
cord-016293-pyb00pt5	858	4	tools	tool	NNS
cord-016293-pyb00pt5	858	5	arising	arise	VBG
cord-016293-pyb00pt5	858	6	from	from	IN
cord-016293-pyb00pt5	858	7	information	information	NN
cord-016293-pyb00pt5	858	8	gathered	gather	VBN
cord-016293-pyb00pt5	858	9	from	from	IN
cord-016293-pyb00pt5	858	10	the	the	DT
cord-016293-pyb00pt5	858	11	human	human	JJ
cord-016293-pyb00pt5	858	12	genome	genome	NN
cord-016293-pyb00pt5	858	13	sequence	sequence	NN
cord-016293-pyb00pt5	858	14	and	and	CC
cord-016293-pyb00pt5	858	15	complementary	complementary	JJ
cord-016293-pyb00pt5	858	16	discoveries	discovery	NNS
cord-016293-pyb00pt5	858	17	in	in	IN
cord-016293-pyb00pt5	858	18	cell	cell	NN
cord-016293-pyb00pt5	858	19	and	and	CC
cord-016293-pyb00pt5	858	20	molecular	molecular	JJ
cord-016293-pyb00pt5	858	21	biology	biology	NN
cord-016293-pyb00pt5	858	22	,	,	,
cord-016293-pyb00pt5	858	23	new	new	JJ
cord-016293-pyb00pt5	858	24	tools	tool	NNS
cord-016293-pyb00pt5	858	25	such	such	JJ
cord-016293-pyb00pt5	858	26	as	as	IN
cord-016293-pyb00pt5	858	27	gene	gene	NN
cord-016293-pyb00pt5	858	28	-	-	HYPH
cord-016293-pyb00pt5	858	29	expression	expression	NN
cord-016293-pyb00pt5	858	30	profiling	profiling	NN
cord-016293-pyb00pt5	858	31	,	,	,
cord-016293-pyb00pt5	858	32	and	and	CC
cord-016293-pyb00pt5	858	33	proteomics	proteomic	NNS
cord-016293-pyb00pt5	858	34	analysis	analysis	NN
cord-016293-pyb00pt5	858	35	are	be	VBP
cord-016293-pyb00pt5	858	36	converging	converge	VBG
cord-016293-pyb00pt5	858	37	to	to	TO
cord-016293-pyb00pt5	858	38	finally	finally	RB
cord-016293-pyb00pt5	858	39	show	show	VB
cord-016293-pyb00pt5	858	40	that	that	IN
cord-016293-pyb00pt5	858	41	rapid	rapid	JJ
cord-016293-pyb00pt5	858	42	robust	robust	JJ
cord-016293-pyb00pt5	858	43	diagnostics	diagnostic	NNS
cord-016293-pyb00pt5	858	44	and	and	CC
cord-016293-pyb00pt5	858	45	"	"	``
cord-016293-pyb00pt5	858	46	rational	rational	JJ
cord-016293-pyb00pt5	858	47	"	"	''
cord-016293-pyb00pt5	858	48	drug	drug	NN
cord-016293-pyb00pt5	858	49	design	design	NN
cord-016293-pyb00pt5	858	50	has	have	VBZ
cord-016293-pyb00pt5	858	51	a	a	DT
cord-016293-pyb00pt5	858	52	future	future	NN
cord-016293-pyb00pt5	858	53	in	in	IN
cord-016293-pyb00pt5	858	54	disease	disease	NN
cord-016293-pyb00pt5	858	55	research	research	NN
cord-016293-pyb00pt5	858	56	.	.	.
cord-016293-pyb00pt5	859	1	Another	another	DT
cord-016293-pyb00pt5	859	2	virus	virus	NN
cord-016293-pyb00pt5	859	3	that	that	WDT
cord-016293-pyb00pt5	859	4	puts	put	VBZ
cord-016293-pyb00pt5	859	5	SARS	SARS	NNP
cord-016293-pyb00pt5	859	6	deaths	death	NNS
cord-016293-pyb00pt5	859	7	in	in	IN
cord-016293-pyb00pt5	859	8	perspective	perspective	NN
cord-016293-pyb00pt5	859	9	benefitted	benefit	VBN
cord-016293-pyb00pt5	859	10	from	from	IN
cord-016293-pyb00pt5	859	11	rational	rational	JJ
cord-016293-pyb00pt5	859	12	drug	drug	NN
cord-016293-pyb00pt5	859	13	design	design	NN
cord-016293-pyb00pt5	859	14	at	at	IN
cord-016293-pyb00pt5	859	15	the	the	DT
cord-016293-pyb00pt5	859	16	turn	turn	NN
cord-016293-pyb00pt5	859	17	of	of	IN
cord-016293-pyb00pt5	859	18	the	the	DT
cord-016293-pyb00pt5	859	19	century	century	NN
cord-016293-pyb00pt5	859	20	.	.	.
cord-016293-pyb00pt5	860	1	Influenza	influenza	NN
cord-016293-pyb00pt5	860	2	,	,	,
cord-016293-pyb00pt5	860	3	or	or	CC
cord-016293-pyb00pt5	860	4	flu	flu	NN
cord-016293-pyb00pt5	860	5	,	,	,
cord-016293-pyb00pt5	860	6	is	be	VBZ
cord-016293-pyb00pt5	860	7	an	an	DT
cord-016293-pyb00pt5	860	8	acute	acute	JJ
cord-016293-pyb00pt5	860	9	respiratory	respiratory	JJ
cord-016293-pyb00pt5	860	10	infection	infection	NN
cord-016293-pyb00pt5	860	11	caused	cause	VBN
cord-016293-pyb00pt5	860	12	by	by	IN
cord-016293-pyb00pt5	860	13	a	a	DT
cord-016293-pyb00pt5	860	14	variety	variety	NN
cord-016293-pyb00pt5	860	15	of	of	IN
cord-016293-pyb00pt5	860	16	influenza	influenza	NN
cord-016293-pyb00pt5	860	17	viruses	virus	NNS
cord-016293-pyb00pt5	860	18	.	.	.
cord-016293-pyb00pt5	861	1	Each	each	DT
cord-016293-pyb00pt5	861	2	year	year	NN
cord-016293-pyb00pt5	861	3	,	,	,
cord-016293-pyb00pt5	861	4	up	up	IN
cord-016293-pyb00pt5	861	5	to	to	TO
cord-016293-pyb00pt5	861	6	40	40	CD
cord-016293-pyb00pt5	861	7	million	million	CD
cord-016293-pyb00pt5	861	8	Americans	Americans	NNPS
cord-016293-pyb00pt5	861	9	develop	develop	VBP
cord-016293-pyb00pt5	861	10	the	the	DT
cord-016293-pyb00pt5	861	11	flu	flu	NN
cord-016293-pyb00pt5	861	12	,	,	,
cord-016293-pyb00pt5	861	13	with	with	IN
cord-016293-pyb00pt5	861	14	an	an	DT
cord-016293-pyb00pt5	861	15	average	average	NN
cord-016293-pyb00pt5	861	16	of	of	IN
cord-016293-pyb00pt5	861	17	about	about	IN
cord-016293-pyb00pt5	861	18	150,000	150,000	CD
cord-016293-pyb00pt5	861	19	being	be	VBG
cord-016293-pyb00pt5	861	20	hospitalized	hospitalize	VBN
cord-016293-pyb00pt5	861	21	and	and	CC
cord-016293-pyb00pt5	861	22	10,000	10,000	CD
cord-016293-pyb00pt5	861	23	to	to	TO
cord-016293-pyb00pt5	861	24	40,000	40,000	CD
cord-016293-pyb00pt5	861	25	people	people	NNS
cord-016293-pyb00pt5	861	26	dying	die	VBG
cord-016293-pyb00pt5	861	27	from	from	IN
cord-016293-pyb00pt5	861	28	influenza	influenza	NN
cord-016293-pyb00pt5	861	29	and	and	CC
cord-016293-pyb00pt5	861	30	its	-PRON-	PRP$
cord-016293-pyb00pt5	861	31	complications	complication	NNS
cord-016293-pyb00pt5	861	32	.	.	.
cord-016293-pyb00pt5	862	1	The	the	DT
cord-016293-pyb00pt5	862	2	use	use	NN
cord-016293-pyb00pt5	862	3	of	of	IN
cord-016293-pyb00pt5	862	4	current	current	JJ
cord-016293-pyb00pt5	862	5	influenza	influenza	NN
cord-016293-pyb00pt5	862	6	treatments	treatment	NNS
cord-016293-pyb00pt5	862	7	has	have	VBZ
cord-016293-pyb00pt5	862	8	been	be	VBN
cord-016293-pyb00pt5	862	9	limited	limit	VBN
cord-016293-pyb00pt5	862	10	due	due	IN
cord-016293-pyb00pt5	862	11	to	to	IN
cord-016293-pyb00pt5	862	12	a	a	DT
cord-016293-pyb00pt5	862	13	lack	lack	NN
cord-016293-pyb00pt5	862	14	of	of	IN
cord-016293-pyb00pt5	862	15	activity	activity	NN
cord-016293-pyb00pt5	862	16	against	against	IN
cord-016293-pyb00pt5	862	17	all	all	DT
cord-016293-pyb00pt5	862	18	influenza	influenza	NN
cord-016293-pyb00pt5	862	19	strains	strain	NNS
cord-016293-pyb00pt5	862	20	,	,	,
cord-016293-pyb00pt5	862	21	adverse	adverse	JJ
cord-016293-pyb00pt5	862	22	side	side	NN
cord-016293-pyb00pt5	862	23	effects	effect	NNS
cord-016293-pyb00pt5	862	24	,	,	,
cord-016293-pyb00pt5	862	25	and	and	CC
cord-016293-pyb00pt5	862	26	rapid	rapid	JJ
cord-016293-pyb00pt5	862	27	development	development	NN
cord-016293-pyb00pt5	862	28	of	of	IN
cord-016293-pyb00pt5	862	29	viral	viral	JJ
cord-016293-pyb00pt5	862	30	resistance	resistance	NN
cord-016293-pyb00pt5	862	31	.	.	.
cord-016293-pyb00pt5	863	1	Influenza	influenza	NN
cord-016293-pyb00pt5	863	2	costs	cost	VBZ
cord-016293-pyb00pt5	863	3	the	the	DT
cord-016293-pyb00pt5	863	4	United	United	NNP
cord-016293-pyb00pt5	863	5	States	States	NNP
cord-016293-pyb00pt5	863	6	an	an	DT
cord-016293-pyb00pt5	863	7	annual	annual	JJ
cord-016293-pyb00pt5	863	8	$	$	$
cord-016293-pyb00pt5	863	9	14.6	14.6	CD
cord-016293-pyb00pt5	863	10	billion	billion	CD
cord-016293-pyb00pt5	863	11	in	in	IN
cord-016293-pyb00pt5	863	12	physician	physician	NN
cord-016293-pyb00pt5	863	13	visits	visit	NNS
cord-016293-pyb00pt5	863	14	,	,	,
cord-016293-pyb00pt5	863	15	lost	lose	VBD
cord-016293-pyb00pt5	863	16	productivity	productivity	NN
cord-016293-pyb00pt5	863	17	and	and	CC
cord-016293-pyb00pt5	863	18	lost	lost	JJ
cord-016293-pyb00pt5	863	19	wages	wage	NNS
cord-016293-pyb00pt5	863	20	.	.	.
cord-016293-pyb00pt5	864	1	And	and	CC
cord-016293-pyb00pt5	864	2	least	least	JJS
cord-016293-pyb00pt5	864	3	we	-PRON-	PRP
cord-016293-pyb00pt5	864	4	still	still	RB
cord-016293-pyb00pt5	864	5	dismiss	dismiss	VBP
cord-016293-pyb00pt5	864	6	it	-PRON-	PRP
cord-016293-pyb00pt5	864	7	as	as	IN
cord-016293-pyb00pt5	864	8	a	a	DT
cord-016293-pyb00pt5	864	9	nuisance	nuisance	NN
cord-016293-pyb00pt5	864	10	we	-PRON-	PRP
cord-016293-pyb00pt5	864	11	are	be	VBP
cord-016293-pyb00pt5	864	12	well	well	JJ
cord-016293-pyb00pt5	864	13	to	to	TO
cord-016293-pyb00pt5	864	14	remember	remember	VB
cord-016293-pyb00pt5	864	15	that	that	IN
cord-016293-pyb00pt5	864	16	the	the	DT
cord-016293-pyb00pt5	864	17	"	"	``
cord-016293-pyb00pt5	864	18	Spanish	spanish	JJ
cord-016293-pyb00pt5	864	19	"	"	''
cord-016293-pyb00pt5	864	20	influenza	influenza	NN
cord-016293-pyb00pt5	864	21	pandemic	pandemic	NN
cord-016293-pyb00pt5	864	22	killed	kill	VBN
cord-016293-pyb00pt5	864	23	over	over	IN
cord-016293-pyb00pt5	864	24	20	20	CD
cord-016293-pyb00pt5	864	25	million	million	CD
cord-016293-pyb00pt5	864	26	people	people	NNS
cord-016293-pyb00pt5	864	27	in	in	IN
cord-016293-pyb00pt5	864	28	1918	1918	CD
cord-016293-pyb00pt5	864	29	and	and	CC
cord-016293-pyb00pt5	864	30	1919	1919	CD
cord-016293-pyb00pt5	864	31	,	,	,
cord-016293-pyb00pt5	864	32	making	make	VBG
cord-016293-pyb00pt5	864	33	it	-PRON-	PRP
cord-016293-pyb00pt5	864	34	the	the	DT
cord-016293-pyb00pt5	864	35	worst	bad	JJS
cord-016293-pyb00pt5	864	36	infectious	infectious	JJ
cord-016293-pyb00pt5	864	37	pandemic	pandemic	NN
cord-016293-pyb00pt5	864	38	in	in	IN
cord-016293-pyb00pt5	864	39	history	history	NN
cord-016293-pyb00pt5	864	40	beating	beat	VBG
cord-016293-pyb00pt5	864	41	out	out	RP
cord-016293-pyb00pt5	864	42	even	even	RB
cord-016293-pyb00pt5	864	43	the	the	DT
cord-016293-pyb00pt5	864	44	more	more	RBR
cord-016293-pyb00pt5	864	45	notorious	notorious	JJ
cord-016293-pyb00pt5	864	46	black	black	JJ
cord-016293-pyb00pt5	864	47	death	death	NN
cord-016293-pyb00pt5	864	48	of	of	IN
cord-016293-pyb00pt5	864	49	the	the	DT
cord-016293-pyb00pt5	864	50	Middle	Middle	NNP
cord-016293-pyb00pt5	864	51	Ages	Ages	NNPS
cord-016293-pyb00pt5	864	52	.	.	.
cord-016293-pyb00pt5	865	1	This	this	DT
cord-016293-pyb00pt5	865	2	fear	fear	NN
cord-016293-pyb00pt5	865	3	has	have	VBZ
cord-016293-pyb00pt5	865	4	been	be	VBN
cord-016293-pyb00pt5	865	5	rekindled	rekindle	VBN
cord-016293-pyb00pt5	865	6	as	as	IN
cord-016293-pyb00pt5	865	7	the	the	DT
cord-016293-pyb00pt5	865	8	dreaded	dreaded	JJ
cord-016293-pyb00pt5	865	9	H5N1	H5N1	NNP
cord-016293-pyb00pt5	865	10	(	(	-LRB-
cord-016293-pyb00pt5	865	11	H	H	NNP
cord-016293-pyb00pt5	865	12	for	for	IN
cord-016293-pyb00pt5	865	13	haemaglutenin	haemaglutenin	NNP
cord-016293-pyb00pt5	865	14	and	and	CC
cord-016293-pyb00pt5	865	15	N	N	NNP
cord-016293-pyb00pt5	865	16	for	for	IN
cord-016293-pyb00pt5	865	17	neuraminidase	neuraminidase	NN
cord-016293-pyb00pt5	865	18	as	as	IN
cord-016293-pyb00pt5	865	19	described	describe	VBN
cord-016293-pyb00pt5	865	20	below	below	IN
cord-016293-pyb00pt5	865	21	)	)	-RRB-
cord-016293-pyb00pt5	865	22	strain	strain	NN
cord-016293-pyb00pt5	865	23	of	of	IN
cord-016293-pyb00pt5	865	24	bird	bird	NN
cord-016293-pyb00pt5	865	25	flu	flu	NN
cord-016293-pyb00pt5	865	26	has	have	VBZ
cord-016293-pyb00pt5	865	27	the	the	DT
cord-016293-pyb00pt5	865	28	potential	potential	NN
cord-016293-pyb00pt5	865	29	to	to	TO
cord-016293-pyb00pt5	865	30	mutate	mutate	VB
cord-016293-pyb00pt5	865	31	and	and	CC
cord-016293-pyb00pt5	865	32	recognise	recognise	VB
cord-016293-pyb00pt5	865	33	homo	homo	NN
cord-016293-pyb00pt5	865	34	sapiens	sapiens	NNP
cord-016293-pyb00pt5	865	35	as	as	IN
cord-016293-pyb00pt5	865	36	a	a	DT
cord-016293-pyb00pt5	865	37	desirable	desirable	JJ
cord-016293-pyb00pt5	865	38	host	host	NN
cord-016293-pyb00pt5	865	39	.	.	.
cord-016293-pyb00pt5	866	1	Since	since	IN
cord-016293-pyb00pt5	866	2	RNA	RNA	NNP
cord-016293-pyb00pt5	866	3	viruses	virus	NNS
cord-016293-pyb00pt5	866	4	are	be	VBP
cord-016293-pyb00pt5	866	5	notoriously	notoriously	RB
cord-016293-pyb00pt5	866	6	faulty	faulty	JJ
cord-016293-pyb00pt5	866	7	in	in	IN
cord-016293-pyb00pt5	866	8	their	-PRON-	PRP$
cord-016293-pyb00pt5	866	9	replication	replication	NN
cord-016293-pyb00pt5	866	10	this	this	DT
cord-016293-pyb00pt5	866	11	accelerated	accelerate	VBN
cord-016293-pyb00pt5	866	12	evolutionary	evolutionary	JJ
cord-016293-pyb00pt5	866	13	process	process	NN
cord-016293-pyb00pt5	866	14	gives	give	VBZ
cord-016293-pyb00pt5	866	15	then	then	RB
cord-016293-pyb00pt5	866	16	a	a	DT
cord-016293-pyb00pt5	866	17	distinct	distinct	JJ
cord-016293-pyb00pt5	866	18	advantage	advantage	NN
cord-016293-pyb00pt5	866	19	when	when	WRB
cord-016293-pyb00pt5	866	20	adapting	adapt	VBG
cord-016293-pyb00pt5	866	21	to	to	IN
cord-016293-pyb00pt5	866	22	new	new	JJ
cord-016293-pyb00pt5	866	23	environments	environment	NNS
cord-016293-pyb00pt5	866	24	and	and	CC
cord-016293-pyb00pt5	866	25	therefore	therefore	RB
cord-016293-pyb00pt5	866	26	finding	find	VBG
cord-016293-pyb00pt5	866	27	more	more	RBR
cord-016293-pyb00pt5	866	28	amenable	amenable	JJ
cord-016293-pyb00pt5	866	29	hosts	host	NNS
cord-016293-pyb00pt5	866	30	.	.	.
cord-016293-pyb00pt5	867	1	Although	although	IN
cord-016293-pyb00pt5	867	2	inactivated	inactivate	VBN
cord-016293-pyb00pt5	867	3	influenza	influenza	NN
cord-016293-pyb00pt5	867	4	vaccines	vaccine	NNS
cord-016293-pyb00pt5	867	5	are	be	VBP
cord-016293-pyb00pt5	867	6	available	available	JJ
cord-016293-pyb00pt5	867	7	,	,	,
cord-016293-pyb00pt5	867	8	their	-PRON-	PRP$
cord-016293-pyb00pt5	867	9	efficacy	efficacy	NN
cord-016293-pyb00pt5	867	10	is	be	VBZ
cord-016293-pyb00pt5	867	11	suboptimal	suboptimal	JJ
cord-016293-pyb00pt5	867	12	partly	partly	RB
cord-016293-pyb00pt5	867	13	because	because	IN
cord-016293-pyb00pt5	867	14	of	of	IN
cord-016293-pyb00pt5	867	15	their	-PRON-	PRP$
cord-016293-pyb00pt5	867	16	limited	limited	JJ
cord-016293-pyb00pt5	867	17	ability	ability	NN
cord-016293-pyb00pt5	867	18	to	to	TO
cord-016293-pyb00pt5	867	19	elicit	elicit	VB
cord-016293-pyb00pt5	867	20	local	local	JJ
cord-016293-pyb00pt5	867	21	IgA	iga	NN
cord-016293-pyb00pt5	867	22	and	and	CC
cord-016293-pyb00pt5	867	23	cytotoxic	cytotoxic	JJ
cord-016293-pyb00pt5	867	24	T	T	NNP
cord-016293-pyb00pt5	867	25	cell	cell	NN
cord-016293-pyb00pt5	867	26	responses	response	NNS
cord-016293-pyb00pt5	867	27	.	.	.
cord-016293-pyb00pt5	868	1	The	the	DT
cord-016293-pyb00pt5	868	2	choices	choice	NNS
cord-016293-pyb00pt5	868	3	of	of	IN
cord-016293-pyb00pt5	868	4	treatments	treatment	NNS
cord-016293-pyb00pt5	868	5	and	and	CC
cord-016293-pyb00pt5	868	6	preventions	prevention	NNS
cord-016293-pyb00pt5	868	7	for	for	IN
cord-016293-pyb00pt5	868	8	influenza	influenza	NN
cord-016293-pyb00pt5	868	9	hold	hold	VBP
cord-016293-pyb00pt5	868	10	much	much	RB
cord-016293-pyb00pt5	868	11	more	more	JJR
cord-016293-pyb00pt5	868	12	promise	promise	NN
cord-016293-pyb00pt5	868	13	in	in	IN
cord-016293-pyb00pt5	868	14	this	this	DT
cord-016293-pyb00pt5	868	15	millennium	millennium	NN
cord-016293-pyb00pt5	868	16	.	.	.
cord-016293-pyb00pt5	869	1	Clinical	clinical	JJ
cord-016293-pyb00pt5	869	2	trials	trial	NNS
cord-016293-pyb00pt5	869	3	of	of	IN
cord-016293-pyb00pt5	869	4	cold	cold	NN
cord-016293-pyb00pt5	869	5	-	-	HYPH
cord-016293-pyb00pt5	869	6	adapted	adapt	VBN
cord-016293-pyb00pt5	869	7	live	live	JJ
cord-016293-pyb00pt5	869	8	influenza	influenza	NN
cord-016293-pyb00pt5	869	9	vaccines	vaccine	NNS
cord-016293-pyb00pt5	869	10	now	now	RB
cord-016293-pyb00pt5	869	11	under	under	IN
cord-016293-pyb00pt5	869	12	way	way	NN
cord-016293-pyb00pt5	869	13	suggest	suggest	VBP
cord-016293-pyb00pt5	869	14	that	that	IN
cord-016293-pyb00pt5	869	15	such	such	JJ
cord-016293-pyb00pt5	869	16	vaccines	vaccine	NNS
cord-016293-pyb00pt5	869	17	are	be	VBP
cord-016293-pyb00pt5	869	18	optimally	optimally	RB
cord-016293-pyb00pt5	869	19	attenuated	attenuate	VBN
cord-016293-pyb00pt5	869	20	,	,	,
cord-016293-pyb00pt5	869	21	so	so	IN
cord-016293-pyb00pt5	869	22	that	that	IN
cord-016293-pyb00pt5	869	23	they	-PRON-	PRP
cord-016293-pyb00pt5	869	24	will	will	MD
cord-016293-pyb00pt5	869	25	not	not	RB
cord-016293-pyb00pt5	869	26	cause	cause	VB
cord-016293-pyb00pt5	869	27	influenza	influenza	NN
cord-016293-pyb00pt5	869	28	symptoms	symptom	NNS
cord-016293-pyb00pt5	869	29	but	but	CC
cord-016293-pyb00pt5	869	30	will	will	MD
cord-016293-pyb00pt5	869	31	still	still	RB
cord-016293-pyb00pt5	869	32	induce	induce	VB
cord-016293-pyb00pt5	869	33	protective	protective	JJ
cord-016293-pyb00pt5	869	34	immunity	immunity	NN
cord-016293-pyb00pt5	869	35	.	.	.
cord-016293-pyb00pt5	870	1	Aviron	Aviron	NNP
cord-016293-pyb00pt5	870	2	(	(	-LRB-
cord-016293-pyb00pt5	870	3	Mountain	Mountain	NNP
cord-016293-pyb00pt5	870	4	View	View	NNP
cord-016293-pyb00pt5	870	5	,	,	,
cord-016293-pyb00pt5	870	6	CA	CA	NNP
cord-016293-pyb00pt5	870	7	)	)	-RRB-
cord-016293-pyb00pt5	870	8	,	,	,
cord-016293-pyb00pt5	870	9	BioChem	BioChem	NNP
cord-016293-pyb00pt5	870	10	Pharma	Pharma	NNP
cord-016293-pyb00pt5	870	11	(	(	-LRB-
cord-016293-pyb00pt5	870	12	Laval	Laval	NNP
cord-016293-pyb00pt5	870	13	,	,	,
cord-016293-pyb00pt5	870	14	Quebec	Quebec	NNP
cord-016293-pyb00pt5	870	15	,	,	,
cord-016293-pyb00pt5	870	16	Canada	Canada	NNP
cord-016293-pyb00pt5	870	17	)	)	-RRB-
cord-016293-pyb00pt5	870	18	,	,	,
cord-016293-pyb00pt5	870	19	Merck	Merck	NNP
cord-016293-pyb00pt5	870	20	(	(	-LRB-
cord-016293-pyb00pt5	870	21	Whitehouse	Whitehouse	NNP
cord-016293-pyb00pt5	870	22	Station	Station	NNP
cord-016293-pyb00pt5	870	23	,	,	,
cord-016293-pyb00pt5	870	24	NJ	NJ	NNP
cord-016293-pyb00pt5	870	25	)	)	-RRB-
cord-016293-pyb00pt5	870	26	,	,	,
cord-016293-pyb00pt5	870	27	Chiron	Chiron	NNP
cord-016293-pyb00pt5	870	28	(	(	-LRB-
cord-016293-pyb00pt5	870	29	Emeryville	Emeryville	NNP
cord-016293-pyb00pt5	870	30	,	,	,
cord-016293-pyb00pt5	870	31	CA	CA	NNP
cord-016293-pyb00pt5	870	32	)	)	-RRB-
cord-016293-pyb00pt5	870	33	,	,	,
cord-016293-pyb00pt5	870	34	and	and	CC
cord-016293-pyb00pt5	870	35	Cortecs	Cortecs	NNP
cord-016293-pyb00pt5	870	36	(	(	-LRB-
cord-016293-pyb00pt5	870	37	London	London	NNP
cord-016293-pyb00pt5	870	38	)	)	-RRB-
cord-016293-pyb00pt5	870	39	,	,	,
cord-016293-pyb00pt5	870	40	all	all	DT
cord-016293-pyb00pt5	870	41	had	have	VBD
cord-016293-pyb00pt5	870	42	influenza	influenza	NN
cord-016293-pyb00pt5	870	43	vaccines	vaccine	NNS
cord-016293-pyb00pt5	870	44	in	in	IN
cord-016293-pyb00pt5	870	45	the	the	DT
cord-016293-pyb00pt5	870	46	clinic	clinic	NN
cord-016293-pyb00pt5	870	47	at	at	IN
cord-016293-pyb00pt5	870	48	the	the	DT
cord-016293-pyb00pt5	870	49	turn	turn	NN
cord-016293-pyb00pt5	870	50	of	of	IN
cord-016293-pyb00pt5	870	51	the	the	DT
cord-016293-pyb00pt5	870	52	century	century	NN
cord-016293-pyb00pt5	870	53	,	,	,
cord-016293-pyb00pt5	870	54	with	with	IN
cord-016293-pyb00pt5	870	55	some	some	DT
cord-016293-pyb00pt5	870	56	of	of	IN
cord-016293-pyb00pt5	870	57	them	-PRON-	PRP
cord-016293-pyb00pt5	870	58	given	give	VBN
cord-016293-pyb00pt5	870	59	intra	intra	RB
cord-016293-pyb00pt5	870	60	-	-	JJ
cord-016293-pyb00pt5	870	61	nasally	nasally	RB
cord-016293-pyb00pt5	870	62	or	or	CC
cord-016293-pyb00pt5	870	63	orally	orally	RB
cord-016293-pyb00pt5	870	64	.	.	.
cord-016293-pyb00pt5	871	1	Meanwhile	meanwhile	RB
cord-016293-pyb00pt5	871	2	,	,	,
cord-016293-pyb00pt5	871	3	the	the	DT
cord-016293-pyb00pt5	871	4	team	team	NN
cord-016293-pyb00pt5	871	5	of	of	IN
cord-016293-pyb00pt5	871	6	Gilead	Gilead	NNP
cord-016293-pyb00pt5	871	7	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	871	8	(	(	-LRB-
cord-016293-pyb00pt5	871	9	Foster	Foster	NNP
cord-016293-pyb00pt5	871	10	City	City	NNP
cord-016293-pyb00pt5	871	11	,	,	,
cord-016293-pyb00pt5	871	12	CA	CA	NNP
cord-016293-pyb00pt5	871	13	)	)	-RRB-
cord-016293-pyb00pt5	871	14	and	and	CC
cord-016293-pyb00pt5	871	15	Hoffmann	Hoffmann	NNP
cord-016293-pyb00pt5	871	16	-	-	HYPH
cord-016293-pyb00pt5	871	17	La	La	NNP
cord-016293-pyb00pt5	871	18	Roche	Roche	NNP
cord-016293-pyb00pt5	871	19	(	(	-LRB-
cord-016293-pyb00pt5	871	20	Basel	Basel	NNP
cord-016293-pyb00pt5	871	21	,	,	,
cord-016293-pyb00pt5	871	22	Switzerland	Switzerland	NNP
cord-016293-pyb00pt5	871	23	)	)	-RRB-
cord-016293-pyb00pt5	871	24	and	and	CC
cord-016293-pyb00pt5	871	25	also	also	RB
cord-016293-pyb00pt5	871	26	GlaxoWellcome	GlaxoWellcome	NNP
cord-016293-pyb00pt5	871	27	(	(	-LRB-
cord-016293-pyb00pt5	871	28	London	London	NNP
cord-016293-pyb00pt5	871	29	)	)	-RRB-
cord-016293-pyb00pt5	871	30	in	in	IN
cord-016293-pyb00pt5	871	31	2000	2000	CD
cord-016293-pyb00pt5	871	32	put	put	VBD
cord-016293-pyb00pt5	871	33	on	on	IN
cord-016293-pyb00pt5	871	34	the	the	DT
cord-016293-pyb00pt5	871	35	market	market	NN
cord-016293-pyb00pt5	871	36	neuraminidase	neuraminidase	FW
cord-016293-pyb00pt5	871	37	inhibitors	inhibitor	NNS
cord-016293-pyb00pt5	871	38	that	that	WDT
cord-016293-pyb00pt5	871	39	block	block	VBP
cord-016293-pyb00pt5	871	40	the	the	DT
cord-016293-pyb00pt5	871	41	replication	replication	NN
cord-016293-pyb00pt5	871	42	of	of	IN
cord-016293-pyb00pt5	871	43	the	the	DT
cord-016293-pyb00pt5	871	44	influenza	influenza	NN
cord-016293-pyb00pt5	871	45	virus	virus	NN
cord-016293-pyb00pt5	871	46	.	.	.
cord-016293-pyb00pt5	872	1	Gilead	Gilead	NNP
cord-016293-pyb00pt5	872	2	was	be	VBD
cord-016293-pyb00pt5	872	3	one	one	CD
cord-016293-pyb00pt5	872	4	of	of	IN
cord-016293-pyb00pt5	872	5	the	the	DT
cord-016293-pyb00pt5	872	6	first	first	JJ
cord-016293-pyb00pt5	872	7	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	872	8	companies	company	NNS
cord-016293-pyb00pt5	872	9	to	to	TO
cord-016293-pyb00pt5	872	10	come	come	VB
cord-016293-pyb00pt5	872	11	out	out	RP
cord-016293-pyb00pt5	872	12	with	with	IN
cord-016293-pyb00pt5	872	13	an	an	DT
cord-016293-pyb00pt5	872	14	anti	anti	JJ
cord-016293-pyb00pt5	872	15	-	-	JJ
cord-016293-pyb00pt5	872	16	flu	flu	JJ
cord-016293-pyb00pt5	872	17	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	872	18	.	.	.
cord-016293-pyb00pt5	873	1	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	873	2	™	™	,
cord-016293-pyb00pt5	873	3	(	(	-LRB-
cord-016293-pyb00pt5	873	4	oseltamivir	oseltamivir	FW
cord-016293-pyb00pt5	873	5	phosphate	phosphate	NN
cord-016293-pyb00pt5	873	6	)	)	-RRB-
cord-016293-pyb00pt5	873	7	was	be	VBD
cord-016293-pyb00pt5	873	8	the	the	DT
cord-016293-pyb00pt5	873	9	first	first	JJ
cord-016293-pyb00pt5	873	10	flu	flu	NN
cord-016293-pyb00pt5	873	11	pill	pill	NN
cord-016293-pyb00pt5	873	12	from	from	IN
cord-016293-pyb00pt5	873	13	this	this	DT
cord-016293-pyb00pt5	873	14	new	new	JJ
cord-016293-pyb00pt5	873	15	class	class	NN
cord-016293-pyb00pt5	873	16	of	of	IN
cord-016293-pyb00pt5	873	17	drugs	drug	NNS
cord-016293-pyb00pt5	873	18	called	call	VBN
cord-016293-pyb00pt5	873	19	neuraminidase	neuraminidase	NN
cord-016293-pyb00pt5	873	20	inhibitors	inhibitor	NNS
cord-016293-pyb00pt5	873	21	(	(	-LRB-
cord-016293-pyb00pt5	873	22	NI	NI	NNP
cord-016293-pyb00pt5	873	23	)	)	-RRB-
cord-016293-pyb00pt5	873	24	that	that	WDT
cord-016293-pyb00pt5	873	25	are	be	VBP
cord-016293-pyb00pt5	873	26	designed	design	VBN
cord-016293-pyb00pt5	873	27	to	to	TO
cord-016293-pyb00pt5	873	28	be	be	VB
cord-016293-pyb00pt5	873	29	active	active	JJ
cord-016293-pyb00pt5	873	30	against	against	IN
cord-016293-pyb00pt5	873	31	all	all	DT
cord-016293-pyb00pt5	873	32	common	common	JJ
cord-016293-pyb00pt5	873	33	strains	strain	NNS
cord-016293-pyb00pt5	873	34	of	of	IN
cord-016293-pyb00pt5	873	35	the	the	DT
cord-016293-pyb00pt5	873	36	influenza	influenza	NN
cord-016293-pyb00pt5	873	37	virus	virus	NN
cord-016293-pyb00pt5	873	38	.	.	.
cord-016293-pyb00pt5	874	1	Neuraminidase	Neuraminidase	NNP
cord-016293-pyb00pt5	874	2	inhibitors	inhibitor	NNS
cord-016293-pyb00pt5	874	3	block	block	VBP
cord-016293-pyb00pt5	874	4	viral	viral	JJ
cord-016293-pyb00pt5	874	5	replication	replication	NN
cord-016293-pyb00pt5	874	6	by	by	IN
cord-016293-pyb00pt5	874	7	targeting	target	VBG
cord-016293-pyb00pt5	874	8	a	a	DT
cord-016293-pyb00pt5	874	9	site	site	NN
cord-016293-pyb00pt5	874	10	on	on	IN
cord-016293-pyb00pt5	874	11	one	one	CD
cord-016293-pyb00pt5	874	12	of	of	IN
cord-016293-pyb00pt5	874	13	the	the	DT
cord-016293-pyb00pt5	874	14	two	two	CD
cord-016293-pyb00pt5	874	15	main	main	JJ
cord-016293-pyb00pt5	874	16	surface	surface	NN
cord-016293-pyb00pt5	874	17	structures	structure	NNS
cord-016293-pyb00pt5	874	18	of	of	IN
cord-016293-pyb00pt5	874	19	the	the	DT
cord-016293-pyb00pt5	874	20	influenza	influenza	NN
cord-016293-pyb00pt5	874	21	virus	virus	NN
cord-016293-pyb00pt5	874	22	,	,	,
cord-016293-pyb00pt5	874	23	preventing	prevent	VBG
cord-016293-pyb00pt5	874	24	the	the	DT
cord-016293-pyb00pt5	874	25	virus	virus	NN
cord-016293-pyb00pt5	874	26	from	from	IN
cord-016293-pyb00pt5	874	27	infecting	infect	VBG
cord-016293-pyb00pt5	874	28	new	new	JJ
cord-016293-pyb00pt5	874	29	cells	cell	NNS
cord-016293-pyb00pt5	874	30	.	.	.
cord-016293-pyb00pt5	875	1	Neuraminidase	Neuraminidase	NNP
cord-016293-pyb00pt5	875	2	is	be	VBZ
cord-016293-pyb00pt5	875	3	found	find	VBN
cord-016293-pyb00pt5	875	4	protruding	protrude	VBG
cord-016293-pyb00pt5	875	5	from	from	IN
cord-016293-pyb00pt5	875	6	the	the	DT
cord-016293-pyb00pt5	875	7	surface	surface	NN
cord-016293-pyb00pt5	875	8	of	of	IN
cord-016293-pyb00pt5	875	9	the	the	DT
cord-016293-pyb00pt5	875	10	two	two	CD
cord-016293-pyb00pt5	875	11	main	main	JJ
cord-016293-pyb00pt5	875	12	types	type	NNS
cord-016293-pyb00pt5	875	13	of	of	IN
cord-016293-pyb00pt5	875	14	influenza	influenza	NN
cord-016293-pyb00pt5	875	15	virus	virus	NN
cord-016293-pyb00pt5	875	16	,	,	,
cord-016293-pyb00pt5	875	17	type	type	NN
cord-016293-pyb00pt5	875	18	A	a	NN
cord-016293-pyb00pt5	875	19	and	and	CC
cord-016293-pyb00pt5	875	20	type	type	NN
cord-016293-pyb00pt5	876	1	B.	B.	NNP
cord-016293-pyb00pt5	877	1	It	-PRON-	PRP
cord-016293-pyb00pt5	877	2	enables	enable	VBZ
cord-016293-pyb00pt5	877	3	newly	newly	RB
cord-016293-pyb00pt5	877	4	formed	form	VBN
cord-016293-pyb00pt5	877	5	viral	viral	JJ
cord-016293-pyb00pt5	877	6	particles	particle	NNS
cord-016293-pyb00pt5	877	7	to	to	TO
cord-016293-pyb00pt5	877	8	travel	travel	VB
cord-016293-pyb00pt5	877	9	from	from	IN
cord-016293-pyb00pt5	877	10	one	one	CD
cord-016293-pyb00pt5	877	11	cell	cell	NN
cord-016293-pyb00pt5	877	12	to	to	IN
cord-016293-pyb00pt5	877	13	another	another	DT
cord-016293-pyb00pt5	877	14	in	in	IN
cord-016293-pyb00pt5	877	15	the	the	DT
cord-016293-pyb00pt5	877	16	body	body	NN
cord-016293-pyb00pt5	877	17	.	.	.
cord-016293-pyb00pt5	878	1	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	878	2	is	be	VBZ
cord-016293-pyb00pt5	878	3	designed	design	VBN
cord-016293-pyb00pt5	878	4	to	to	TO
cord-016293-pyb00pt5	878	5	prevent	prevent	VB
cord-016293-pyb00pt5	878	6	all	all	DT
cord-016293-pyb00pt5	878	7	common	common	JJ
cord-016293-pyb00pt5	878	8	strains	strain	NNS
cord-016293-pyb00pt5	878	9	of	of	IN
cord-016293-pyb00pt5	878	10	the	the	DT
cord-016293-pyb00pt5	878	11	influenza	influenza	NN
cord-016293-pyb00pt5	878	12	virus	virus	NN
cord-016293-pyb00pt5	878	13	from	from	IN
cord-016293-pyb00pt5	878	14	replicating	replicate	VBG
cord-016293-pyb00pt5	878	15	.	.	.
cord-016293-pyb00pt5	879	1	The	the	DT
cord-016293-pyb00pt5	879	2	replication	replication	NN
cord-016293-pyb00pt5	879	3	process	process	NN
cord-016293-pyb00pt5	879	4	is	be	VBZ
cord-016293-pyb00pt5	879	5	what	what	WP
cord-016293-pyb00pt5	879	6	contributes	contribute	VBZ
cord-016293-pyb00pt5	879	7	to	to	IN
cord-016293-pyb00pt5	879	8	the	the	DT
cord-016293-pyb00pt5	879	9	worsening	worsen	VBG
cord-016293-pyb00pt5	879	10	of	of	IN
cord-016293-pyb00pt5	879	11	symptoms	symptom	NNS
cord-016293-pyb00pt5	879	12	in	in	IN
cord-016293-pyb00pt5	879	13	a	a	DT
cord-016293-pyb00pt5	879	14	person	person	NN
cord-016293-pyb00pt5	879	15	infected	infect	VBN
cord-016293-pyb00pt5	879	16	with	with	IN
cord-016293-pyb00pt5	879	17	the	the	DT
cord-016293-pyb00pt5	879	18	influenza	influenza	NN
cord-016293-pyb00pt5	879	19	virus	virus	NN
cord-016293-pyb00pt5	879	20	.	.	.
cord-016293-pyb00pt5	880	1	By	by	IN
cord-016293-pyb00pt5	880	2	inactivating	inactivate	VBG
cord-016293-pyb00pt5	880	3	neuraminidase	neuraminidase	NN
cord-016293-pyb00pt5	880	4	,	,	,
cord-016293-pyb00pt5	880	5	viral	viral	JJ
cord-016293-pyb00pt5	880	6	replication	replication	NN
cord-016293-pyb00pt5	880	7	is	be	VBZ
cord-016293-pyb00pt5	880	8	stopped	stop	VBN
cord-016293-pyb00pt5	880	9	,	,	,
cord-016293-pyb00pt5	880	10	halting	halt	VBG
cord-016293-pyb00pt5	880	11	the	the	DT
cord-016293-pyb00pt5	880	12	influenza	influenza	NN
cord-016293-pyb00pt5	880	13	virus	virus	NN
cord-016293-pyb00pt5	880	14	in	in	IN
cord-016293-pyb00pt5	880	15	its	-PRON-	PRP$
cord-016293-pyb00pt5	880	16	tracks	track	NNS
cord-016293-pyb00pt5	880	17	.	.	.
cord-016293-pyb00pt5	881	1	In	in	IN
cord-016293-pyb00pt5	881	2	marked	marked	JJ
cord-016293-pyb00pt5	881	3	contrast	contrast	NN
cord-016293-pyb00pt5	881	4	to	to	IN
cord-016293-pyb00pt5	881	5	the	the	DT
cord-016293-pyb00pt5	881	6	usual	usual	JJ
cord-016293-pyb00pt5	881	7	protracted	protracted	JJ
cord-016293-pyb00pt5	881	8	process	process	NN
cord-016293-pyb00pt5	881	9	of	of	IN
cord-016293-pyb00pt5	881	10	clinical	clinical	JJ
cord-016293-pyb00pt5	881	11	trials	trial	NNS
cord-016293-pyb00pt5	881	12	for	for	IN
cord-016293-pyb00pt5	881	13	new	new	JJ
cord-016293-pyb00pt5	881	14	therapeutics	therapeutic	NNS
cord-016293-pyb00pt5	881	15	,	,	,
cord-016293-pyb00pt5	881	16	the	the	DT
cord-016293-pyb00pt5	881	17	road	road	NN
cord-016293-pyb00pt5	881	18	from	from	IN
cord-016293-pyb00pt5	881	19	conception	conception	NN
cord-016293-pyb00pt5	881	20	to	to	TO
cord-016293-pyb00pt5	881	21	application	application	NN
cord-016293-pyb00pt5	881	22	for	for	IN
cord-016293-pyb00pt5	881	23	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	881	24	was	be	VBD
cord-016293-pyb00pt5	881	25	remarkably	remarkably	RB
cord-016293-pyb00pt5	881	26	expeditious	expeditious	JJ
cord-016293-pyb00pt5	881	27	.	.	.
cord-016293-pyb00pt5	882	1	In	in	IN
cord-016293-pyb00pt5	882	2	1996	1996	CD
cord-016293-pyb00pt5	882	3	,	,	,
cord-016293-pyb00pt5	882	4	Gilead	Gilead	NNP
cord-016293-pyb00pt5	882	5	and	and	CC
cord-016293-pyb00pt5	882	6	Hoffmann	Hoffmann	NNP
cord-016293-pyb00pt5	882	7	-	-	HYPH
cord-016293-pyb00pt5	882	8	La	La	NNP
cord-016293-pyb00pt5	882	9	Roche	Roche	NNP
cord-016293-pyb00pt5	882	10	entered	enter	VBD
cord-016293-pyb00pt5	882	11	into	into	IN
cord-016293-pyb00pt5	882	12	a	a	DT
cord-016293-pyb00pt5	882	13	collaborative	collaborative	JJ
cord-016293-pyb00pt5	882	14	agreement	agreement	NN
cord-016293-pyb00pt5	882	15	to	to	TO
cord-016293-pyb00pt5	882	16	develop	develop	VB
cord-016293-pyb00pt5	882	17	and	and	CC
cord-016293-pyb00pt5	882	18	market	market	NN
cord-016293-pyb00pt5	882	19	therapies	therapy	NNS
cord-016293-pyb00pt5	882	20	that	that	WDT
cord-016293-pyb00pt5	882	21	treat	treat	VBP
cord-016293-pyb00pt5	882	22	and	and	CC
cord-016293-pyb00pt5	882	23	prevent	prevent	VB
cord-016293-pyb00pt5	882	24	viral	viral	JJ
cord-016293-pyb00pt5	882	25	influenza	influenza	NN
cord-016293-pyb00pt5	882	26	.	.	.
cord-016293-pyb00pt5	883	1	In	in	IN
cord-016293-pyb00pt5	883	2	1999	1999	CD
cord-016293-pyb00pt5	883	3	,	,	,
cord-016293-pyb00pt5	883	4	as	as	IN
cord-016293-pyb00pt5	883	5	Gilead	Gilead	NNP
cord-016293-pyb00pt5	883	6	's	's	POS
cord-016293-pyb00pt5	883	7	worldwide	worldwide	JJ
cord-016293-pyb00pt5	883	8	development	development	NN
cord-016293-pyb00pt5	883	9	and	and	CC
cord-016293-pyb00pt5	883	10	marketing	marketing	NN
cord-016293-pyb00pt5	883	11	partner	partner	NN
cord-016293-pyb00pt5	883	12	,	,	,
cord-016293-pyb00pt5	883	13	Roche	Roche	NNP
cord-016293-pyb00pt5	883	14	led	lead	VBD
cord-016293-pyb00pt5	883	15	the	the	DT
cord-016293-pyb00pt5	883	16	final	final	JJ
cord-016293-pyb00pt5	883	17	development	development	NN
cord-016293-pyb00pt5	883	18	of	of	IN
cord-016293-pyb00pt5	883	19	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	883	20	,	,	,
cord-016293-pyb00pt5	883	21	26	26	CD
cord-016293-pyb00pt5	883	22	months	month	NNS
cord-016293-pyb00pt5	883	23	after	after	IN
cord-016293-pyb00pt5	883	24	the	the	DT
cord-016293-pyb00pt5	883	25	first	first	JJ
cord-016293-pyb00pt5	883	26	patient	patient	NN
cord-016293-pyb00pt5	883	27	was	be	VBD
cord-016293-pyb00pt5	883	28	dosed	dose	VBN
cord-016293-pyb00pt5	883	29	in	in	IN
cord-016293-pyb00pt5	883	30	clinical	clinical	JJ
cord-016293-pyb00pt5	883	31	trials	trial	NNS
cord-016293-pyb00pt5	883	32	in	in	IN
cord-016293-pyb00pt5	883	33	April	April	NNP
cord-016293-pyb00pt5	883	34	1999	1999	CD
cord-016293-pyb00pt5	883	35	,	,	,
cord-016293-pyb00pt5	883	36	Roche	Roche	NNP
cord-016293-pyb00pt5	883	37	and	and	CC
cord-016293-pyb00pt5	883	38	Gilead	Gilead	NNP
cord-016293-pyb00pt5	883	39	announced	announce	VBD
cord-016293-pyb00pt5	883	40	the	the	DT
cord-016293-pyb00pt5	883	41	submission	submission	NN
cord-016293-pyb00pt5	883	42	of	of	IN
cord-016293-pyb00pt5	883	43	a	a	DT
cord-016293-pyb00pt5	883	44	New	New	NNP
cord-016293-pyb00pt5	883	45	Drug	Drug	NNP
cord-016293-pyb00pt5	883	46	Application	Application	NNP
cord-016293-pyb00pt5	883	47	to	to	IN
cord-016293-pyb00pt5	883	48	the	the	DT
cord-016293-pyb00pt5	883	49	U.S.	U.S.	NNP
cord-016293-pyb00pt5	883	50	Food	Food	NNP
cord-016293-pyb00pt5	883	51	and	and	CC
cord-016293-pyb00pt5	883	52	Drug	Drug	NNP
cord-016293-pyb00pt5	883	53	Administration	Administration	NNP
cord-016293-pyb00pt5	883	54	(	(	-LRB-
cord-016293-pyb00pt5	883	55	FDA	FDA	NNP
cord-016293-pyb00pt5	883	56	)	)	-RRB-
cord-016293-pyb00pt5	883	57	for	for	IN
cord-016293-pyb00pt5	883	58	the	the	DT
cord-016293-pyb00pt5	883	59	treatment	treatment	NN
cord-016293-pyb00pt5	883	60	of	of	IN
cord-016293-pyb00pt5	883	61	influenza	influenza	NN
cord-016293-pyb00pt5	883	62	.	.	.
cord-016293-pyb00pt5	884	1	Additionally	additionally	RB
cord-016293-pyb00pt5	884	2	,	,	,
cord-016293-pyb00pt5	884	3	Roche	Roche	NNP
cord-016293-pyb00pt5	884	4	filed	file	VBD
cord-016293-pyb00pt5	884	5	a	a	DT
cord-016293-pyb00pt5	884	6	Marketing	Marketing	NNP
cord-016293-pyb00pt5	884	7	Authorisation	Authorisation	NNP
cord-016293-pyb00pt5	884	8	Application	Application	NNP
cord-016293-pyb00pt5	884	9	(	(	-LRB-
cord-016293-pyb00pt5	884	10	MAA	MAA	NNP
cord-016293-pyb00pt5	884	11	)	)	-RRB-
cord-016293-pyb00pt5	884	12	in	in	IN
cord-016293-pyb00pt5	884	13	the	the	DT
cord-016293-pyb00pt5	884	14	European	European	NNP
cord-016293-pyb00pt5	884	15	Union	Union	NNP
cord-016293-pyb00pt5	884	16	under	under	IN
cord-016293-pyb00pt5	884	17	the	the	DT
cord-016293-pyb00pt5	884	18	centralized	centralized	JJ
cord-016293-pyb00pt5	884	19	procedure	procedure	NN
cord-016293-pyb00pt5	884	20	in	in	IN
cord-016293-pyb00pt5	884	21	early	early	JJ
cord-016293-pyb00pt5	884	22	May	May	NNP
cord-016293-pyb00pt5	884	23	1999	1999	CD
cord-016293-pyb00pt5	884	24	.	.	.
cord-016293-pyb00pt5	885	1	Six	six	CD
cord-016293-pyb00pt5	885	2	months	month	NNS
cord-016293-pyb00pt5	885	3	later	later	RB
cord-016293-pyb00pt5	885	4	in	in	IN
cord-016293-pyb00pt5	885	5	October	October	NNP
cord-016293-pyb00pt5	885	6	1999	1999	CD
cord-016293-pyb00pt5	885	7	,	,	,
cord-016293-pyb00pt5	885	8	Gilead	Gilead	NNP
cord-016293-pyb00pt5	885	9	and	and	CC
cord-016293-pyb00pt5	885	10	Roche	Roche	NNP
cord-016293-pyb00pt5	885	11	announced	announce	VBD
cord-016293-pyb00pt5	885	12	that	that	IN
cord-016293-pyb00pt5	885	13	the	the	DT
cord-016293-pyb00pt5	885	14	FDA	FDA	NNP
cord-016293-pyb00pt5	885	15	approved	approve	VBD
cord-016293-pyb00pt5	885	16	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	885	17	for	for	IN
cord-016293-pyb00pt5	885	18	the	the	DT
cord-016293-pyb00pt5	885	19	treatment	treatment	NN
cord-016293-pyb00pt5	885	20	of	of	IN
cord-016293-pyb00pt5	885	21	influenza	influenza	NN
cord-016293-pyb00pt5	885	22	A	a	NN
cord-016293-pyb00pt5	885	23	and	and	CC
cord-016293-pyb00pt5	885	24	B	b	NN
cord-016293-pyb00pt5	885	25	in	in	IN
cord-016293-pyb00pt5	885	26	adults	adult	NNS
cord-016293-pyb00pt5	885	27	.	.	.
cord-016293-pyb00pt5	886	1	These	these	DT
cord-016293-pyb00pt5	886	2	accelerated	accelerate	VBN
cord-016293-pyb00pt5	886	3	efforts	effort	NNS
cord-016293-pyb00pt5	886	4	allowed	allow	VBD
cord-016293-pyb00pt5	886	5	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	886	6	to	to	TO
cord-016293-pyb00pt5	886	7	reach	reach	VB
cord-016293-pyb00pt5	886	8	the	the	DT
cord-016293-pyb00pt5	886	9	U.S.	U.S.	NNP
cord-016293-pyb00pt5	886	10	market	market	NN
cord-016293-pyb00pt5	886	11	in	in	IN
cord-016293-pyb00pt5	886	12	time	time	NN
cord-016293-pyb00pt5	886	13	for	for	IN
cord-016293-pyb00pt5	886	14	the	the	DT
cord-016293-pyb00pt5	886	15	1999	1999	CD
cord-016293-pyb00pt5	886	16	-	-	SYM
cord-016293-pyb00pt5	886	17	2000	2000	CD
cord-016293-pyb00pt5	886	18	flu	flu	NN
cord-016293-pyb00pt5	886	19	season	season	NN
cord-016293-pyb00pt5	886	20	.	.	.
cord-016293-pyb00pt5	887	1	One	one	CD
cord-016293-pyb00pt5	887	2	of	of	IN
cord-016293-pyb00pt5	887	3	Gilead	Gilead	NNP
cord-016293-pyb00pt5	887	4	's	's	POS
cord-016293-pyb00pt5	887	5	studies	study	NNS
cord-016293-pyb00pt5	887	6	showed	show	VBD
cord-016293-pyb00pt5	887	7	an	an	DT
cord-016293-pyb00pt5	887	8	increase	increase	NN
cord-016293-pyb00pt5	887	9	in	in	IN
cord-016293-pyb00pt5	887	10	efficacy	efficacy	NN
cord-016293-pyb00pt5	887	11	from	from	IN
cord-016293-pyb00pt5	887	12	60	60	CD
cord-016293-pyb00pt5	887	13	%	%	NN
cord-016293-pyb00pt5	887	14	when	when	WRB
cord-016293-pyb00pt5	887	15	the	the	DT
cord-016293-pyb00pt5	887	16	vaccine	vaccine	NN
cord-016293-pyb00pt5	887	17	was	be	VBD
cord-016293-pyb00pt5	887	18	used	use	VBN
cord-016293-pyb00pt5	887	19	alone	alone	RB
cord-016293-pyb00pt5	887	20	to	to	IN
cord-016293-pyb00pt5	887	21	92	92	CD
cord-016293-pyb00pt5	887	22	%	%	NN
cord-016293-pyb00pt5	887	23	when	when	WRB
cord-016293-pyb00pt5	887	24	the	the	DT
cord-016293-pyb00pt5	887	25	vaccine	vaccine	NN
cord-016293-pyb00pt5	887	26	was	be	VBD
cord-016293-pyb00pt5	887	27	used	use	VBN
cord-016293-pyb00pt5	887	28	in	in	IN
cord-016293-pyb00pt5	887	29	conjunction	conjunction	NN
cord-016293-pyb00pt5	887	30	with	with	IN
cord-016293-pyb00pt5	887	31	a	a	DT
cord-016293-pyb00pt5	887	32	neuraminidase	neuraminidase	NN
cord-016293-pyb00pt5	887	33	inhibitor	inhibitor	NN
cord-016293-pyb00pt5	887	34	.	.	.
cord-016293-pyb00pt5	888	1	Outside	outside	IN
cord-016293-pyb00pt5	888	2	of	of	IN
cord-016293-pyb00pt5	888	3	the	the	DT
cord-016293-pyb00pt5	888	4	U.S.	U.S.	NNP
cord-016293-pyb00pt5	888	5	,	,	,
cord-016293-pyb00pt5	888	6	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	888	7	also	also	RB
cord-016293-pyb00pt5	888	8	has	have	VBZ
cord-016293-pyb00pt5	888	9	been	be	VBN
cord-016293-pyb00pt5	888	10	approved	approve	VBN
cord-016293-pyb00pt5	888	11	for	for	IN
cord-016293-pyb00pt5	888	12	the	the	DT
cord-016293-pyb00pt5	888	13	treatment	treatment	NN
cord-016293-pyb00pt5	888	14	of	of	IN
cord-016293-pyb00pt5	888	15	influenza	influenza	NN
cord-016293-pyb00pt5	888	16	A	a	NN
cord-016293-pyb00pt5	888	17	and	and	CC
cord-016293-pyb00pt5	888	18	B	B	NNP
cord-016293-pyb00pt5	888	19	in	in	IN
cord-016293-pyb00pt5	888	20	Argentina	Argentina	NNP
cord-016293-pyb00pt5	888	21	,	,	,
cord-016293-pyb00pt5	888	22	Brazil	Brazil	NNP
cord-016293-pyb00pt5	888	23	,	,	,
cord-016293-pyb00pt5	888	24	Canada	Canada	NNP
cord-016293-pyb00pt5	888	25	,	,	,
cord-016293-pyb00pt5	888	26	Mexico	Mexico	NNP
cord-016293-pyb00pt5	888	27	,	,	,
cord-016293-pyb00pt5	888	28	Peru	Peru	NNP
cord-016293-pyb00pt5	888	29	and	and	CC
cord-016293-pyb00pt5	888	30	Switzerland	Switzerland	NNP
cord-016293-pyb00pt5	888	31	.	.	.
cord-016293-pyb00pt5	889	1	Regulatory	regulatory	JJ
cord-016293-pyb00pt5	889	2	review	review	NN
cord-016293-pyb00pt5	889	3	of	of	IN
cord-016293-pyb00pt5	889	4	the	the	DT
cord-016293-pyb00pt5	889	5	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	889	6	MAA	MAA	NNP
cord-016293-pyb00pt5	889	7	by	by	IN
cord-016293-pyb00pt5	889	8	European	european	JJ
cord-016293-pyb00pt5	889	9	authorities	authority	NNS
cord-016293-pyb00pt5	889	10	is	be	VBZ
cord-016293-pyb00pt5	889	11	ongoing	ongoing	JJ
cord-016293-pyb00pt5	889	12	.	.	.
cord-016293-pyb00pt5	890	1	With	with	IN
cord-016293-pyb00pt5	890	2	the	the	DT
cord-016293-pyb00pt5	890	3	H5N1	H5N1	NNP
cord-016293-pyb00pt5	890	4	birdflu	birdflu	NNP
cord-016293-pyb00pt5	890	5	strain	strain	NN
cord-016293-pyb00pt5	890	6	's	's	POS
cord-016293-pyb00pt5	890	7	relentless	relentless	JJ
cord-016293-pyb00pt5	890	8	march	march	NN
cord-016293-pyb00pt5	890	9	(	(	-LRB-
cord-016293-pyb00pt5	890	10	or	or	CC
cord-016293-pyb00pt5	890	11	rather	rather	RB
cord-016293-pyb00pt5	890	12	flight	flight	NN
cord-016293-pyb00pt5	890	13	)	)	-RRB-
cord-016293-pyb00pt5	890	14	across	across	IN
cord-016293-pyb00pt5	890	15	Asia	Asia	NNP
cord-016293-pyb00pt5	890	16	,	,	,
cord-016293-pyb00pt5	890	17	in	in	IN
cord-016293-pyb00pt5	890	18	2006	2006	CD
cord-016293-pyb00pt5	890	19	through	through	IN
cord-016293-pyb00pt5	890	20	Eastern	Eastern	NNP
cord-016293-pyb00pt5	890	21	Europe	Europe	NNP
cord-016293-pyb00pt5	890	22	to	to	IN
cord-016293-pyb00pt5	890	23	a	a	DT
cord-016293-pyb00pt5	890	24	French	french	JJ
cord-016293-pyb00pt5	890	25	farmyard	farmyard	NN
cord-016293-pyb00pt5	890	26	,	,	,
cord-016293-pyb00pt5	890	27	an	an	DT
cord-016293-pyb00pt5	890	28	unwelcome	unwelcome	JJ
cord-016293-pyb00pt5	890	29	stowaway	stowaway	NN
cord-016293-pyb00pt5	890	30	on	on	IN
cord-016293-pyb00pt5	890	31	a	a	DT
cord-016293-pyb00pt5	890	32	winged	winged	JJ
cord-016293-pyb00pt5	890	33	migration	migration	NN
cord-016293-pyb00pt5	890	34	,	,	,
cord-016293-pyb00pt5	890	35	and	and	CC
cord-016293-pyb00pt5	890	36	no	no	DT
cord-016293-pyb00pt5	890	37	vaccine	vaccine	NN
cord-016293-pyb00pt5	890	38	in	in	IN
cord-016293-pyb00pt5	890	39	sight	sight	NN
cord-016293-pyb00pt5	890	40	,	,	,
cord-016293-pyb00pt5	890	41	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	890	42	,	,	,
cord-016293-pyb00pt5	890	43	although	although	IN
cord-016293-pyb00pt5	890	44	untested	untested	JJ
cord-016293-pyb00pt5	890	45	for	for	IN
cord-016293-pyb00pt5	890	46	this	this	DT
cord-016293-pyb00pt5	890	47	species	species	NN
cord-016293-pyb00pt5	890	48	,	,	,
cord-016293-pyb00pt5	890	49	seen	see	VBN
cord-016293-pyb00pt5	890	50	as	as	IN
cord-016293-pyb00pt5	890	51	the	the	DT
cord-016293-pyb00pt5	890	52	last	last	JJ
cord-016293-pyb00pt5	890	53	line	line	NN
cord-016293-pyb00pt5	890	54	of	of	IN
cord-016293-pyb00pt5	890	55	defense	defense	NN
cord-016293-pyb00pt5	890	56	is	be	VBZ
cord-016293-pyb00pt5	890	57	now	now	RB
cord-016293-pyb00pt5	890	58	being	be	VBG
cord-016293-pyb00pt5	890	59	horded	horde	VBN
cord-016293-pyb00pt5	890	60	and	and	CC
cord-016293-pyb00pt5	890	61	its	-PRON-	PRP$
cord-016293-pyb00pt5	890	62	patented	patent	VBN
cord-016293-pyb00pt5	890	63	production	production	NN
cord-016293-pyb00pt5	890	64	right	right	NN
cord-016293-pyb00pt5	890	65	's	be	VBZ
cord-016293-pyb00pt5	890	66	fought	fight	VBN
cord-016293-pyb00pt5	890	67	over	over	RP
cord-016293-pyb00pt5	890	68	like	like	IN
cord-016293-pyb00pt5	890	69	an	an	DT
cord-016293-pyb00pt5	890	70	alchemist	alchemist	NN
cord-016293-pyb00pt5	890	71	's	's	POS
cord-016293-pyb00pt5	890	72	formula	formula	NN
cord-016293-pyb00pt5	890	73	.	.	.
cord-016293-pyb00pt5	891	1	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	891	2	's	's	POS
cord-016293-pyb00pt5	891	3	main	main	JJ
cord-016293-pyb00pt5	891	4	competitor	competitor	NN
cord-016293-pyb00pt5	891	5	,	,	,
cord-016293-pyb00pt5	891	6	Zanamivir	Zanamivir	NNP
cord-016293-pyb00pt5	891	7	marketed	market	VBD
cord-016293-pyb00pt5	891	8	as	as	IN
cord-016293-pyb00pt5	891	9	Relenza	Relenza	NNP
cord-016293-pyb00pt5	891	10	™	™	NN
cord-016293-pyb00pt5	891	11	was	be	VBD
cord-016293-pyb00pt5	891	12	one	one	CD
cord-016293-pyb00pt5	891	13	of	of	IN
cord-016293-pyb00pt5	891	14	a	a	DT
cord-016293-pyb00pt5	891	15	group	group	NN
cord-016293-pyb00pt5	891	16	of	of	IN
cord-016293-pyb00pt5	891	17	molecules	molecule	NNS
cord-016293-pyb00pt5	891	18	developed	develop	VBN
cord-016293-pyb00pt5	891	19	by	by	IN
cord-016293-pyb00pt5	891	20	GlaxoWellcome	GlaxoWellcome	NNP
cord-016293-pyb00pt5	891	21	and	and	CC
cord-016293-pyb00pt5	891	22	academic	academic	JJ
cord-016293-pyb00pt5	891	23	collaborators	collaborator	NNS
cord-016293-pyb00pt5	891	24	using	use	VBG
cord-016293-pyb00pt5	891	25	structure	structure	NN
cord-016293-pyb00pt5	891	26	-	-	HYPH
cord-016293-pyb00pt5	891	27	based	base	VBN
cord-016293-pyb00pt5	891	28	drug	drug	NN
cord-016293-pyb00pt5	891	29	design	design	NN
cord-016293-pyb00pt5	891	30	methods	method	NNS
cord-016293-pyb00pt5	891	31	targeted	target	VBN
cord-016293-pyb00pt5	891	32	,	,	,
cord-016293-pyb00pt5	891	33	like	like	IN
cord-016293-pyb00pt5	891	34	Tamiflu	Tamiflu	NNP
cord-016293-pyb00pt5	891	35	,	,	,
cord-016293-pyb00pt5	891	36	at	at	IN
cord-016293-pyb00pt5	891	37	a	a	DT
cord-016293-pyb00pt5	891	38	region	region	NN
cord-016293-pyb00pt5	891	39	of	of	IN
cord-016293-pyb00pt5	891	40	the	the	DT
cord-016293-pyb00pt5	891	41	neuraminidase	neuraminidase	NN
cord-016293-pyb00pt5	891	42	surface	surface	NN
cord-016293-pyb00pt5	891	43	glycoprotein	glycoprotein	NN
cord-016293-pyb00pt5	891	44	of	of	IN
cord-016293-pyb00pt5	891	45	influenza	influenza	NN
cord-016293-pyb00pt5	891	46	viruses	virus	NNS
cord-016293-pyb00pt5	891	47	that	that	WDT
cord-016293-pyb00pt5	891	48	is	be	VBZ
cord-016293-pyb00pt5	891	49	highly	highly	RB
cord-016293-pyb00pt5	891	50	conserved	conserve	VBN
cord-016293-pyb00pt5	891	51	from	from	IN
cord-016293-pyb00pt5	891	52	strain	strain	NN
cord-016293-pyb00pt5	891	53	to	to	TO
cord-016293-pyb00pt5	891	54	strain	strain	VB
cord-016293-pyb00pt5	891	55	.	.	.
cord-016293-pyb00pt5	892	1	Glaxo	Glaxo	NNP
cord-016293-pyb00pt5	892	2	filed	file	VBD
cord-016293-pyb00pt5	892	3	for	for	IN
cord-016293-pyb00pt5	892	4	marketing	marketing	NN
cord-016293-pyb00pt5	892	5	approval	approval	NN
cord-016293-pyb00pt5	892	6	for	for	IN
cord-016293-pyb00pt5	892	7	Relenza	Relenza	NNP
cord-016293-pyb00pt5	892	8	in	in	IN
cord-016293-pyb00pt5	892	9	Europe	Europe	NNP
cord-016293-pyb00pt5	892	10	and	and	CC
cord-016293-pyb00pt5	892	11	Canada	Canada	NNP
cord-016293-pyb00pt5	892	12	.	.	.
cord-016293-pyb00pt5	893	1	The	the	DT
cord-016293-pyb00pt5	893	2	Food	Food	NNP
cord-016293-pyb00pt5	893	3	and	and	CC
cord-016293-pyb00pt5	893	4	Drug	Drug	NNP
cord-016293-pyb00pt5	893	5	Administration	Administration	NNP
cord-016293-pyb00pt5	893	6	's	's	POS
cord-016293-pyb00pt5	893	7	accelerated	accelerate	VBN
cord-016293-pyb00pt5	893	8	drug	drug	NN
cord-016293-pyb00pt5	893	9	-	-	HYPH
cord-016293-pyb00pt5	893	10	approval	approval	NN
cord-016293-pyb00pt5	893	11	timetable	timetable	NN
cord-016293-pyb00pt5	893	12	began	begin	VBD
cord-016293-pyb00pt5	893	13	to	to	TO
cord-016293-pyb00pt5	893	14	show	show	VB
cord-016293-pyb00pt5	893	15	results	result	NNS
cord-016293-pyb00pt5	893	16	by	by	IN
cord-016293-pyb00pt5	893	17	2001	2001	CD
cord-016293-pyb00pt5	893	18	,	,	,
cord-016293-pyb00pt5	893	19	its	-PRON-	PRP$
cord-016293-pyb00pt5	893	20	evaluation	evaluation	NN
cord-016293-pyb00pt5	893	21	of	of	IN
cord-016293-pyb00pt5	893	22	Novartis	Novartis	NNP
cord-016293-pyb00pt5	893	23	's	's	POS
cord-016293-pyb00pt5	893	24	Gleevec	Gleevec	NNP
cord-016293-pyb00pt5	893	25	took	take	VBD
cord-016293-pyb00pt5	893	26	just	just	RB
cord-016293-pyb00pt5	893	27	three	three	CD
cord-016293-pyb00pt5	893	28	months	month	NNS
cord-016293-pyb00pt5	893	29	compared	compare	VBN
cord-016293-pyb00pt5	893	30	with	with	IN
cord-016293-pyb00pt5	893	31	the	the	DT
cord-016293-pyb00pt5	893	32	standard	standard	JJ
cord-016293-pyb00pt5	893	33	10	10	CD
cord-016293-pyb00pt5	893	34	-	-	SYM
cord-016293-pyb00pt5	893	35	12	12	CD
cord-016293-pyb00pt5	893	36	months	month	NNS
cord-016293-pyb00pt5	893	37	.	.	.
cord-016293-pyb00pt5	894	1	Another	another	DT
cord-016293-pyb00pt5	894	2	factor	factor	NN
cord-016293-pyb00pt5	894	3	in	in	IN
cord-016293-pyb00pt5	894	4	improving	improve	VBG
cord-016293-pyb00pt5	894	5	biotherapeutic	biotherapeutic	JJ
cord-016293-pyb00pt5	894	6	fortunes	fortune	NNS
cord-016293-pyb00pt5	894	7	in	in	IN
cord-016293-pyb00pt5	894	8	the	the	DT
cord-016293-pyb00pt5	894	9	new	new	JJ
cord-016293-pyb00pt5	894	10	century	century	NN
cord-016293-pyb00pt5	894	11	was	be	VBD
cord-016293-pyb00pt5	894	12	the	the	DT
cord-016293-pyb00pt5	894	13	staggering	staggering	JJ
cord-016293-pyb00pt5	894	14	profits	profit	NNS
cord-016293-pyb00pt5	894	15	of	of	IN
cord-016293-pyb00pt5	894	16	early	early	JJ
cord-016293-pyb00pt5	894	17	successes	success	NNS
cord-016293-pyb00pt5	894	18	.	.	.
cord-016293-pyb00pt5	895	1	In	in	IN
cord-016293-pyb00pt5	895	2	2003	2003	CD
cord-016293-pyb00pt5	895	3	,	,	,
cord-016293-pyb00pt5	895	4	$	$	$
cord-016293-pyb00pt5	895	5	1.9	1.9	CD
cord-016293-pyb00pt5	895	6	billion	billion	CD
cord-016293-pyb00pt5	895	7	of	of	IN
cord-016293-pyb00pt5	895	8	the	the	DT
cord-016293-pyb00pt5	895	9	$	$	$
cord-016293-pyb00pt5	895	10	3.3	3.3	CD
cord-016293-pyb00pt5	895	11	billion	billion	CD
cord-016293-pyb00pt5	895	12	in	in	IN
cord-016293-pyb00pt5	895	13	revenue	revenue	NN
cord-016293-pyb00pt5	895	14	collected	collect	VBN
cord-016293-pyb00pt5	895	15	by	by	IN
cord-016293-pyb00pt5	895	16	Genentech	Genentech	NNP
cord-016293-pyb00pt5	895	17	in	in	IN
cord-016293-pyb00pt5	895	18	South	South	NNP
cord-016293-pyb00pt5	895	19	San	San	NNP
cord-016293-pyb00pt5	895	20	Francisco	Francisco	NNP
cord-016293-pyb00pt5	895	21	came	come	VBD
cord-016293-pyb00pt5	895	22	from	from	IN
cord-016293-pyb00pt5	895	23	oncology	oncology	NN
cord-016293-pyb00pt5	895	24	products	product	NNS
cord-016293-pyb00pt5	895	25	,	,	,
cord-016293-pyb00pt5	895	26	mostly	mostly	RB
cord-016293-pyb00pt5	895	27	the	the	DT
cord-016293-pyb00pt5	895	28	monoclonal	monoclonal	JJ
cord-016293-pyb00pt5	895	29	antibody	antibody	NN
cord-016293-pyb00pt5	895	30	-	-	HYPH
cord-016293-pyb00pt5	895	31	based	base	VBN
cord-016293-pyb00pt5	895	32	drugs	drug	NNS
cord-016293-pyb00pt5	895	33	Rituxan	Rituxan	NNP
cord-016293-pyb00pt5	895	34	,	,	,
cord-016293-pyb00pt5	895	35	used	use	VBN
cord-016293-pyb00pt5	895	36	to	to	TO
cord-016293-pyb00pt5	895	37	treat	treat	VB
cord-016293-pyb00pt5	895	38	non	non	JJ
cord-016293-pyb00pt5	895	39	-	-	JJ
cord-016293-pyb00pt5	895	40	Hodgkin	Hodgkin	NNP
cord-016293-pyb00pt5	895	41	's	's	POS
cord-016293-pyb00pt5	895	42	lymphoma	lymphoma	NN
cord-016293-pyb00pt5	895	43	,	,	,
cord-016293-pyb00pt5	895	44	and	and	CC
cord-016293-pyb00pt5	895	45	Herceptin	Herceptin	NNP
cord-016293-pyb00pt5	895	46	for	for	IN
cord-016293-pyb00pt5	895	47	breast	breast	NN
cord-016293-pyb00pt5	895	48	cancer	cancer	NN
cord-016293-pyb00pt5	895	49	.	.	.
cord-016293-pyb00pt5	896	1	In	in	IN
cord-016293-pyb00pt5	896	2	fact	fact	NN
cord-016293-pyb00pt5	896	3	two	two	CD
cord-016293-pyb00pt5	896	4	of	of	IN
cord-016293-pyb00pt5	896	5	the	the	DT
cord-016293-pyb00pt5	896	6	first	first	JJ
cord-016293-pyb00pt5	896	7	cancer	cancer	NN
cord-016293-pyb00pt5	896	8	drugs	drug	NNS
cord-016293-pyb00pt5	896	9	to	to	TO
cord-016293-pyb00pt5	896	10	use	use	VB
cord-016293-pyb00pt5	896	11	the	the	DT
cord-016293-pyb00pt5	896	12	new	new	JJ
cord-016293-pyb00pt5	896	13	tools	tool	NNS
cord-016293-pyb00pt5	896	14	for	for	IN
cord-016293-pyb00pt5	896	15	'	'	``
cord-016293-pyb00pt5	896	16	rational	rational	JJ
cord-016293-pyb00pt5	896	17	'	'	''
cord-016293-pyb00pt5	896	18	design	design	NN
cord-016293-pyb00pt5	896	19	Herceptin	Herceptin	NNP
cord-016293-pyb00pt5	896	20	and	and	CC
cord-016293-pyb00pt5	896	21	Gleevec	Gleevec	NNP
cord-016293-pyb00pt5	896	22	,	,	,
cord-016293-pyb00pt5	896	23	a	a	DT
cord-016293-pyb00pt5	896	24	small	small	JJ
cord-016293-pyb00pt5	896	25	-	-	HYPH
cord-016293-pyb00pt5	896	26	molecule	molecule	NN
cord-016293-pyb00pt5	896	27	chemotherapeutic	chemotherapeutic	JJ
cord-016293-pyb00pt5	896	28	for	for	IN
cord-016293-pyb00pt5	896	29	some	some	DT
cord-016293-pyb00pt5	896	30	forms	form	NNS
cord-016293-pyb00pt5	896	31	of	of	IN
cord-016293-pyb00pt5	896	32	leukemia	leukemia	NN
cord-016293-pyb00pt5	896	33	are	be	VBP
cord-016293-pyb00pt5	896	34	proving	prove	VBG
cord-016293-pyb00pt5	896	35	successful	successful	JJ
cord-016293-pyb00pt5	896	36	,	,	,
cord-016293-pyb00pt5	896	37	and	and	CC
cord-016293-pyb00pt5	896	38	others	other	NNS
cord-016293-pyb00pt5	896	39	such	such	JJ
cord-016293-pyb00pt5	896	40	as	as	IN
cord-016293-pyb00pt5	896	41	Avastin	Avastin	NNP
cord-016293-pyb00pt5	896	42	(	(	-LRB-
cord-016293-pyb00pt5	896	43	an	an	DT
cord-016293-pyb00pt5	896	44	anti	anti	JJ
cord-016293-pyb00pt5	896	45	-	-	JJ
cord-016293-pyb00pt5	896	46	vascular	vascular	JJ
cord-016293-pyb00pt5	896	47	endothelial	endothelial	JJ
cord-016293-pyb00pt5	896	48	growth	growth	NN
cord-016293-pyb00pt5	896	49	factor	factor	NN
cord-016293-pyb00pt5	896	50	)	)	-RRB-
cord-016293-pyb00pt5	896	51	for	for	IN
cord-016293-pyb00pt5	896	52	colon	colon	NN
cord-016293-pyb00pt5	896	53	cancer	cancer	NN
cord-016293-pyb00pt5	896	54	and	and	CC
cord-016293-pyb00pt5	896	55	Erbitux	Erbitux	NNP
cord-016293-pyb00pt5	896	56	are	be	VBP
cord-016293-pyb00pt5	896	57	already	already	RB
cord-016293-pyb00pt5	896	58	following	follow	VBG
cord-016293-pyb00pt5	896	59	in	in	IN
cord-016293-pyb00pt5	896	60	their	-PRON-	PRP$
cord-016293-pyb00pt5	896	61	footsteps	footstep	NNS
cord-016293-pyb00pt5	896	62	.	.	.
cord-016293-pyb00pt5	897	1	Gleevec	Gleevec	NNP
cord-016293-pyb00pt5	897	2	led	lead	VBD
cord-016293-pyb00pt5	897	3	the	the	DT
cord-016293-pyb00pt5	897	4	way	way	NN
cord-016293-pyb00pt5	897	5	in	in	IN
cord-016293-pyb00pt5	897	6	exploiting	exploit	VBG
cord-016293-pyb00pt5	897	7	signal	signal	NN
cord-016293-pyb00pt5	897	8	-	-	HYPH
cord-016293-pyb00pt5	897	9	transduction	transduction	NN
cord-016293-pyb00pt5	897	10	pathways	pathway	NNS
cord-016293-pyb00pt5	897	11	to	to	TO
cord-016293-pyb00pt5	897	12	treat	treat	VB
cord-016293-pyb00pt5	897	13	cancer	cancer	NN
cord-016293-pyb00pt5	897	14	as	as	IN
cord-016293-pyb00pt5	897	15	it	-PRON-	PRP
cord-016293-pyb00pt5	897	16	blocks	block	VBZ
cord-016293-pyb00pt5	897	17	a	a	DT
cord-016293-pyb00pt5	897	18	mutant	mutant	JJ
cord-016293-pyb00pt5	897	19	form	form	NN
cord-016293-pyb00pt5	897	20	of	of	IN
cord-016293-pyb00pt5	897	21	tyrosine	tyrosine	NN
cord-016293-pyb00pt5	897	22	kinase	kinase	NN
cord-016293-pyb00pt5	897	23	(	(	-LRB-
cord-016293-pyb00pt5	897	24	termed	term	VBN
cord-016293-pyb00pt5	897	25	the	the	DT
cord-016293-pyb00pt5	897	26	Philadelphia	Philadelphia	NNP
cord-016293-pyb00pt5	897	27	translocation	translocation	NN
cord-016293-pyb00pt5	897	28	recognized	recognize	VBN
cord-016293-pyb00pt5	897	29	in	in	IN
cord-016293-pyb00pt5	897	30	1960	1960	CD
cord-016293-pyb00pt5	897	31	's	's	POS
cord-016293-pyb00pt5	897	32	)	)	-RRB-
cord-016293-pyb00pt5	897	33	that	that	WDT
cord-016293-pyb00pt5	897	34	can	can	MD
cord-016293-pyb00pt5	897	35	help	help	VB
cord-016293-pyb00pt5	897	36	to	to	TO
cord-016293-pyb00pt5	897	37	trigger	trigger	VB
cord-016293-pyb00pt5	897	38	out	out	RP
cord-016293-pyb00pt5	897	39	-	-	HYPH
cord-016293-pyb00pt5	897	40	of	of	IN
cord-016293-pyb00pt5	897	41	-	-	HYPH
cord-016293-pyb00pt5	897	42	control	control	NN
cord-016293-pyb00pt5	897	43	cell	cell	NN
cord-016293-pyb00pt5	897	44	division	division	NN
cord-016293-pyb00pt5	897	45	.	.	.
cord-016293-pyb00pt5	898	1	About	about	RB
cord-016293-pyb00pt5	898	2	25	25	CD
cord-016293-pyb00pt5	898	3	%	%	NN
cord-016293-pyb00pt5	898	4	of	of	IN
cord-016293-pyb00pt5	898	5	biotech	biotech	JJ
cord-016293-pyb00pt5	898	6	companies	company	NNS
cord-016293-pyb00pt5	898	7	raising	raise	VBG
cord-016293-pyb00pt5	898	8	venture	venture	NN
cord-016293-pyb00pt5	898	9	capital	capital	NN
cord-016293-pyb00pt5	898	10	during	during	IN
cord-016293-pyb00pt5	898	11	the	the	DT
cord-016293-pyb00pt5	898	12	third	third	JJ
cord-016293-pyb00pt5	898	13	quarter	quarter	NN
cord-016293-pyb00pt5	898	14	of	of	IN
cord-016293-pyb00pt5	898	15	2003	2003	CD
cord-016293-pyb00pt5	898	16	listed	list	VBN
cord-016293-pyb00pt5	898	17	cancer	cancer	NN
cord-016293-pyb00pt5	898	18	as	as	IN
cord-016293-pyb00pt5	898	19	their	-PRON-	PRP$
cord-016293-pyb00pt5	898	20	primary	primary	JJ
cord-016293-pyb00pt5	898	21	focus	focus	NN
cord-016293-pyb00pt5	898	22	,	,	,
cord-016293-pyb00pt5	898	23	according	accord	VBG
cord-016293-pyb00pt5	898	24	to	to	IN
cord-016293-pyb00pt5	898	25	online	online	JJ
cord-016293-pyb00pt5	898	26	newsletter	newsletter	NN
cord-016293-pyb00pt5	898	27	VentureReporter	VentureReporter	NNP
cord-016293-pyb00pt5	898	28	.	.	.
cord-016293-pyb00pt5	899	1	By	by	IN
cord-016293-pyb00pt5	899	2	2002	2002	CD
cord-016293-pyb00pt5	899	3	according	accord	VBG
cord-016293-pyb00pt5	899	4	to	to	IN
cord-016293-pyb00pt5	899	5	the	the	DT
cord-016293-pyb00pt5	899	6	Pharmaceutical	Pharmaceutical	NNP
cord-016293-pyb00pt5	899	7	Research	Research	NNP
cord-016293-pyb00pt5	899	8	and	and	CC
cord-016293-pyb00pt5	899	9	Manufacturers	Manufacturers	NNPS
cord-016293-pyb00pt5	899	10	of	of	IN
cord-016293-pyb00pt5	899	11	America	America	NNP
cord-016293-pyb00pt5	899	12	,	,	,
cord-016293-pyb00pt5	899	13	402	402	CD
cord-016293-pyb00pt5	899	14	medicines	medicine	NNS
cord-016293-pyb00pt5	899	15	were	be	VBD
cord-016293-pyb00pt5	899	16	in	in	IN
cord-016293-pyb00pt5	899	17	development	development	NN
cord-016293-pyb00pt5	899	18	for	for	IN
cord-016293-pyb00pt5	899	19	cancer	cancer	NN
cord-016293-pyb00pt5	899	20	up	up	RB
cord-016293-pyb00pt5	899	21	from	from	IN
cord-016293-pyb00pt5	899	22	215	215	CD
cord-016293-pyb00pt5	899	23	in	in	IN
cord-016293-pyb00pt5	899	24	1996	1996	CD
cord-016293-pyb00pt5	899	25	.	.	.
cord-016293-pyb00pt5	900	1	Another	another	DT
cord-016293-pyb00pt5	900	2	new	new	JJ
cord-016293-pyb00pt5	900	3	avenue	avenue	NN
cord-016293-pyb00pt5	900	4	in	in	IN
cord-016293-pyb00pt5	900	5	cancer	cancer	NN
cord-016293-pyb00pt5	900	6	research	research	NN
cord-016293-pyb00pt5	900	7	is	be	VBZ
cord-016293-pyb00pt5	900	8	to	to	TO
cord-016293-pyb00pt5	900	9	combine	combine	VB
cord-016293-pyb00pt5	900	10	drugs	drug	NNS
cord-016293-pyb00pt5	900	11	.	.	.
cord-016293-pyb00pt5	901	1	Wyeth	Wyeth	NNP
cord-016293-pyb00pt5	901	2	's	's	POS
cord-016293-pyb00pt5	901	3	Mylotarg	Mylotarg	NNP
cord-016293-pyb00pt5	901	4	,	,	,
cord-016293-pyb00pt5	901	5	for	for	IN
cord-016293-pyb00pt5	901	6	instance	instance	NN
cord-016293-pyb00pt5	901	7	,	,	,
cord-016293-pyb00pt5	901	8	links	link	VBZ
cord-016293-pyb00pt5	901	9	an	an	DT
cord-016293-pyb00pt5	901	10	antibody	antibody	NN
cord-016293-pyb00pt5	901	11	to	to	IN
cord-016293-pyb00pt5	901	12	a	a	DT
cord-016293-pyb00pt5	901	13	chemotherapeutic	chemotherapeutic	JJ
cord-016293-pyb00pt5	901	14	,	,	,
cord-016293-pyb00pt5	901	15	and	and	CC
cord-016293-pyb00pt5	901	16	homes	home	NNS
cord-016293-pyb00pt5	901	17	in	in	IN
cord-016293-pyb00pt5	901	18	on	on	IN
cord-016293-pyb00pt5	901	19	CD33	CD33	NNP
cord-016293-pyb00pt5	901	20	receptors	receptor	NNS
cord-016293-pyb00pt5	901	21	on	on	IN
cord-016293-pyb00pt5	901	22	acute	acute	JJ
cord-016293-pyb00pt5	901	23	myeloid	myeloid	JJ
cord-016293-pyb00pt5	901	24	leukemia	leukemia	NN
cord-016293-pyb00pt5	901	25	cells	cell	NNS
cord-016293-pyb00pt5	901	26	.	.	.
cord-016293-pyb00pt5	902	1	Expertise	expertise	NN
cord-016293-pyb00pt5	902	2	in	in	IN
cord-016293-pyb00pt5	902	3	biochemistry	biochemistry	NN
cord-016293-pyb00pt5	902	4	,	,	,
cord-016293-pyb00pt5	902	5	cell	cell	NN
cord-016293-pyb00pt5	902	6	biology	biology	NN
cord-016293-pyb00pt5	902	7	and	and	CC
cord-016293-pyb00pt5	902	8	immunology	immunology	NN
cord-016293-pyb00pt5	902	9	is	be	VBZ
cord-016293-pyb00pt5	902	10	required	require	VBN
cord-016293-pyb00pt5	902	11	to	to	TO
cord-016293-pyb00pt5	902	12	develop	develop	VB
cord-016293-pyb00pt5	902	13	such	such	PDT
cord-016293-pyb00pt5	902	14	a	a	DT
cord-016293-pyb00pt5	902	15	drug	drug	NN
cord-016293-pyb00pt5	902	16	.	.	.
cord-016293-pyb00pt5	903	1	This	this	DT
cord-016293-pyb00pt5	903	2	trend	trend	NN
cord-016293-pyb00pt5	903	3	has	have	VBZ
cord-016293-pyb00pt5	903	4	created	create	VBN
cord-016293-pyb00pt5	903	5	some	some	DT
cord-016293-pyb00pt5	903	6	bright	bright	JJ
cord-016293-pyb00pt5	903	7	spots	spot	NNS
cord-016293-pyb00pt5	903	8	in	in	IN
cord-016293-pyb00pt5	903	9	cancer	cancer	NN
cord-016293-pyb00pt5	903	10	research	research	NN
cord-016293-pyb00pt5	903	11	and	and	CC
cord-016293-pyb00pt5	903	12	development	development	NN
cord-016293-pyb00pt5	903	13	,	,	,
cord-016293-pyb00pt5	903	14	even	even	RB
cord-016293-pyb00pt5	903	15	though	though	IN
cord-016293-pyb00pt5	903	16	drug	drug	NN
cord-016293-pyb00pt5	903	17	discovery	discovery	NN
cord-016293-pyb00pt5	903	18	in	in	IN
cord-016293-pyb00pt5	903	19	general	general	JJ
cord-016293-pyb00pt5	903	20	has	have	VBZ
cord-016293-pyb00pt5	903	21	been	be	VBN
cord-016293-pyb00pt5	903	22	adversely	adversely	RB
cord-016293-pyb00pt5	903	23	affected	affect	VBN
cord-016293-pyb00pt5	903	24	by	by	IN
cord-016293-pyb00pt5	903	25	mergers	merger	NNS
cord-016293-pyb00pt5	903	26	,	,	,
cord-016293-pyb00pt5	903	27	a	a	DT
cord-016293-pyb00pt5	903	28	few	few	JJ
cord-016293-pyb00pt5	903	29	high	high	JJ
cord-016293-pyb00pt5	903	30	-	-	HYPH
cord-016293-pyb00pt5	903	31	profile	profile	NN
cord-016293-pyb00pt5	903	32	failures	failure	NNS
cord-016293-pyb00pt5	903	33	and	and	CC
cord-016293-pyb00pt5	903	34	a	a	DT
cord-016293-pyb00pt5	903	35	shaky	shaky	JJ
cord-016293-pyb00pt5	903	36	US	US	NNP
cord-016293-pyb00pt5	903	37	economy	economy	NN
cord-016293-pyb00pt5	903	38	in	in	IN
cord-016293-pyb00pt5	903	39	the	the	DT
cord-016293-pyb00pt5	903	40	early	early	JJ
cord-016293-pyb00pt5	903	41	2000	2000	CD
cord-016293-pyb00pt5	903	42	's	's	POS
cord-016293-pyb00pt5	903	43	.	.	.
cord-016293-pyb00pt5	904	1	As	as	IN
cord-016293-pyb00pt5	904	2	the	the	DT
cord-016293-pyb00pt5	904	3	millennium	millennium	NN
cord-016293-pyb00pt5	904	4	approached	approach	VBD
cord-016293-pyb00pt5	904	5	observers	observer	NNS
cord-016293-pyb00pt5	904	6	as	as	RB
cord-016293-pyb00pt5	904	7	diverse	diverse	JJ
cord-016293-pyb00pt5	904	8	as	as	IN
cord-016293-pyb00pt5	904	9	Microsoft	Microsoft	NNP
cord-016293-pyb00pt5	904	10	's	's	POS
cord-016293-pyb00pt5	904	11	Bill	Bill	NNP
cord-016293-pyb00pt5	904	12	Gates	Gates	NNP
cord-016293-pyb00pt5	904	13	and	and	CC
cord-016293-pyb00pt5	904	14	President	President	NNP
cord-016293-pyb00pt5	904	15	Bill	Bill	NNP
cord-016293-pyb00pt5	904	16	Clinton	Clinton	NNP
cord-016293-pyb00pt5	904	17	predicted	predict	VBD
cord-016293-pyb00pt5	904	18	the	the	DT
cord-016293-pyb00pt5	904	19	21st	21st	JJ
cord-016293-pyb00pt5	904	20	century	century	NN
cord-016293-pyb00pt5	904	21	wiould	wiould	MD
cord-016293-pyb00pt5	904	22	be	be	VB
cord-016293-pyb00pt5	904	23	the	the	DT
cord-016293-pyb00pt5	904	24	"	"	``
cord-016293-pyb00pt5	904	25	biology	biology	NN
cord-016293-pyb00pt5	904	26	century	century	NN
cord-016293-pyb00pt5	904	27	"	"	''
cord-016293-pyb00pt5	904	28	.	.	.
cord-016293-pyb00pt5	905	1	By	by	IN
cord-016293-pyb00pt5	905	2	1999	1999	CD
cord-016293-pyb00pt5	905	3	the	the	DT
cord-016293-pyb00pt5	905	4	many	many	JJ
cord-016293-pyb00pt5	905	5	programs	program	NNS
cord-016293-pyb00pt5	905	6	and	and	CC
cord-016293-pyb00pt5	905	7	initiatives	initiative	NNS
cord-016293-pyb00pt5	905	8	underway	underway	JJ
cord-016293-pyb00pt5	905	9	at	at	IN
cord-016293-pyb00pt5	905	10	major	major	JJ
cord-016293-pyb00pt5	905	11	research	research	NN
cord-016293-pyb00pt5	905	12	institutions	institution	NNS
cord-016293-pyb00pt5	905	13	and	and	CC
cord-016293-pyb00pt5	905	14	leading	lead	VBG
cord-016293-pyb00pt5	905	15	companies	company	NNS
cord-016293-pyb00pt5	905	16	were	be	VBD
cord-016293-pyb00pt5	905	17	already	already	RB
cord-016293-pyb00pt5	905	18	giving	give	VBG
cord-016293-pyb00pt5	905	19	shape	shape	NN
cord-016293-pyb00pt5	905	20	to	to	IN
cord-016293-pyb00pt5	905	21	this	this	DT
cord-016293-pyb00pt5	905	22	assertion	assertion	NN
cord-016293-pyb00pt5	905	23	.	.	.
cord-016293-pyb00pt5	906	1	These	these	DT
cord-016293-pyb00pt5	906	2	initiatives	initiative	NNS
cord-016293-pyb00pt5	906	3	have	have	VBP
cord-016293-pyb00pt5	906	4	ushered	usher	VBN
cord-016293-pyb00pt5	906	5	in	in	IN
cord-016293-pyb00pt5	906	6	a	a	DT
cord-016293-pyb00pt5	906	7	new	new	JJ
cord-016293-pyb00pt5	906	8	era	era	NN
cord-016293-pyb00pt5	906	9	of	of	IN
cord-016293-pyb00pt5	906	10	biological	biological	JJ
cord-016293-pyb00pt5	906	11	research	research	NN
cord-016293-pyb00pt5	906	12	anticipated	anticipate	VBN
cord-016293-pyb00pt5	906	13	to	to	TO
cord-016293-pyb00pt5	906	14	generate	generate	VB
cord-016293-pyb00pt5	906	15	technological	technological	JJ
cord-016293-pyb00pt5	906	16	changes	change	NNS
cord-016293-pyb00pt5	906	17	of	of	IN
cord-016293-pyb00pt5	906	18	the	the	DT
cord-016293-pyb00pt5	906	19	magnitude	magnitude	NN
cord-016293-pyb00pt5	906	20	associated	associate	VBN
cord-016293-pyb00pt5	906	21	with	with	IN
cord-016293-pyb00pt5	906	22	the	the	DT
cord-016293-pyb00pt5	906	23	industrial	industrial	JJ
cord-016293-pyb00pt5	906	24	revolution	revolution	NN
cord-016293-pyb00pt5	906	25	and	and	CC
cord-016293-pyb00pt5	906	26	the	the	DT
cord-016293-pyb00pt5	906	27	computerbased	computerbased	JJ
cord-016293-pyb00pt5	906	28	information	information	NN
cord-016293-pyb00pt5	906	29	revolution	revolution	NN
cord-016293-pyb00pt5	906	30	.	.	.
cord-016293-pyb00pt5	907	1	Complementary	complementary	JJ
cord-016293-pyb00pt5	907	2	DNA	dna	NN
cord-016293-pyb00pt5	907	3	sequencing	sequencing	NN
cord-016293-pyb00pt5	907	4	:	:	:
cord-016293-pyb00pt5	907	5	expressed	express	VBD
cord-016293-pyb00pt5	907	6	sequence	sequence	NN
cord-016293-pyb00pt5	907	7	tags	tag	NNS
cord-016293-pyb00pt5	907	8	and	and	CC
cord-016293-pyb00pt5	907	9	human	human	JJ
cord-016293-pyb00pt5	907	10	genome	genome	NN
cord-016293-pyb00pt5	907	11	project	project	NN
cord-016293-pyb00pt5	908	1	Basic	basic	JJ
cord-016293-pyb00pt5	908	2	local	local	JJ
cord-016293-pyb00pt5	908	3	alignment	alignment	NN
cord-016293-pyb00pt5	908	4	search	search	NN
cord-016293-pyb00pt5	908	5	tool	tool	NN
cord-016293-pyb00pt5	909	1	High	high	JJ
cord-016293-pyb00pt5	909	2	-	-	HYPH
cord-016293-pyb00pt5	909	3	tech	tech	NN
cord-016293-pyb00pt5	909	4	herbal	herbal	JJ
cord-016293-pyb00pt5	909	5	medicine	medicine	NN
cord-016293-pyb00pt5	909	6	:	:	:
cord-016293-pyb00pt5	910	1	Plant	plant	NN
cord-016293-pyb00pt5	910	2	-	-	HYPH
cord-016293-pyb00pt5	910	3	Based	base	VBN
cord-016293-pyb00pt5	910	4	Vaccines	Vaccines	NNPS
cord-016293-pyb00pt5	910	5	Asilomar	Asilomar	NNP
cord-016293-pyb00pt5	910	6	conference	conference	NN
cord-016293-pyb00pt5	910	7	on	on	IN
cord-016293-pyb00pt5	910	8	recombinant	recombinant	JJ
cord-016293-pyb00pt5	910	9	DNA	dna	NN
cord-016293-pyb00pt5	910	10	molecules	molecule	NNS
cord-016293-pyb00pt5	911	1	Potential	potential	JJ
cord-016293-pyb00pt5	911	2	biohazards	biohazard	NNS
cord-016293-pyb00pt5	911	3	of	of	IN
cord-016293-pyb00pt5	911	4	recombinant	recombinant	JJ
cord-016293-pyb00pt5	911	5	DNA	dna	NN
cord-016293-pyb00pt5	911	6	molecules	molecule	NNS
cord-016293-pyb00pt5	911	7	HUGO	HUGO	NNP
cord-016293-pyb00pt5	911	8	:	:	:
cord-016293-pyb00pt5	912	1	The	the	DT
cord-016293-pyb00pt5	912	2	Human	Human	NNP
cord-016293-pyb00pt5	912	3	Genome	Genome	NNP
cord-016293-pyb00pt5	912	4	Organization	Organization	NNP
cord-016293-pyb00pt5	912	5	Chimeric	chimeric	JJ
cord-016293-pyb00pt5	912	6	plant	plant	NN
cord-016293-pyb00pt5	912	7	virus	virus	NN
cord-016293-pyb00pt5	912	8	particles	particle	NNS
cord-016293-pyb00pt5	912	9	administered	administer	VBN
cord-016293-pyb00pt5	912	10	nasally	nasally	RB
cord-016293-pyb00pt5	912	11	or	or	CC
cord-016293-pyb00pt5	912	12	orally	orally	RB
cord-016293-pyb00pt5	912	13	induce	induce	VBP
cord-016293-pyb00pt5	912	14	systemic	systemic	JJ
cord-016293-pyb00pt5	912	15	and	and	CC
cord-016293-pyb00pt5	912	16	mucosal	mucosal	JJ
cord-016293-pyb00pt5	912	17	immune	immune	JJ
cord-016293-pyb00pt5	912	18	responses	response	NNS
cord-016293-pyb00pt5	912	19	in	in	IN
cord-016293-pyb00pt5	912	20	mice	mouse	NNS
cord-016293-pyb00pt5	913	1	The	the	DT
cord-016293-pyb00pt5	913	2	human	human	JJ
cord-016293-pyb00pt5	913	3	genome	genome	NN
cord-016293-pyb00pt5	913	4	:	:	:
cord-016293-pyb00pt5	913	5	the	the	DT
cord-016293-pyb00pt5	913	6	nature	nature	NN
cord-016293-pyb00pt5	913	7	of	of	IN
cord-016293-pyb00pt5	913	8	the	the	DT
cord-016293-pyb00pt5	913	9	enterprise	enterprise	NN
cord-016293-pyb00pt5	913	10	Orchestrating	orchestrate	VBG
cord-016293-pyb00pt5	913	11	the	the	DT
cord-016293-pyb00pt5	913	12	Human	Human	NNP
cord-016293-pyb00pt5	913	13	Genome	Genome	NNP
cord-016293-pyb00pt5	913	14	Project	Project	NNP
cord-016293-pyb00pt5	913	15	Separation	Separation	NNP
cord-016293-pyb00pt5	913	16	and	and	CC
cord-016293-pyb00pt5	913	17	analysis	analysis	NN
cord-016293-pyb00pt5	913	18	of	of	IN
cord-016293-pyb00pt5	913	19	DNA	dna	NN
cord-016293-pyb00pt5	913	20	sequence	sequence	NN
cord-016293-pyb00pt5	913	21	reaction	reaction	NN
cord-016293-pyb00pt5	913	22	products	product	NNS
cord-016293-pyb00pt5	913	23	by	by	IN
cord-016293-pyb00pt5	913	24	capillary	capillary	JJ
cord-016293-pyb00pt5	913	25	gel	gel	NN
cord-016293-pyb00pt5	913	26	electrophoresis	electrophoresis	NN
cord-016293-pyb00pt5	913	27	Nutritional	nutritional	JJ
cord-016293-pyb00pt5	913	28	genomics	genomic	NNS
cord-016293-pyb00pt5	913	29	:	:	:
cord-016293-pyb00pt5	913	30	Manipulating	manipulate	VBG
cord-016293-pyb00pt5	913	31	plant	plant	NN
cord-016293-pyb00pt5	913	32	micronutrients	micronutrient	NNS
cord-016293-pyb00pt5	913	33	to	to	TO
cord-016293-pyb00pt5	913	34	improve	improve	VB
cord-016293-pyb00pt5	913	35	human	human	JJ
cord-016293-pyb00pt5	913	36	health	health	NN
cord-016293-pyb00pt5	914	1	Helping	help	VBG
cord-016293-pyb00pt5	914	2	Europe	Europe	NNP
cord-016293-pyb00pt5	914	3	compete	compete	VB
cord-016293-pyb00pt5	914	4	in	in	IN
cord-016293-pyb00pt5	914	5	human	human	JJ
cord-016293-pyb00pt5	914	6	genome	genome	NN
cord-016293-pyb00pt5	914	7	research	research	NN
cord-016293-pyb00pt5	914	8	Genome	Genome	NNP
cord-016293-pyb00pt5	914	9	project	project	NN
cord-016293-pyb00pt5	914	10	gets	get	VBZ
cord-016293-pyb00pt5	914	11	rough	rough	JJ
cord-016293-pyb00pt5	914	12	ride	ride	NN
cord-016293-pyb00pt5	914	13	in	in	IN
cord-016293-pyb00pt5	914	14	Europe	Europe	NNP
cord-016293-pyb00pt5	914	15	Construction	Construction	NNP
cord-016293-pyb00pt5	914	16	of	of	IN
cord-016293-pyb00pt5	914	17	a	a	DT
cord-016293-pyb00pt5	914	18	linkage	linkage	NN
cord-016293-pyb00pt5	914	19	map	map	NN
cord-016293-pyb00pt5	914	20	of	of	IN
cord-016293-pyb00pt5	914	21	the	the	DT
cord-016293-pyb00pt5	914	22	human	human	JJ
cord-016293-pyb00pt5	914	23	genome	genome	NN
cord-016293-pyb00pt5	914	24	,	,	,
cord-016293-pyb00pt5	914	25	and	and	CC
cord-016293-pyb00pt5	914	26	its	-PRON-	PRP$
cord-016293-pyb00pt5	914	27	application	application	NN
cord-016293-pyb00pt5	914	28	to	to	IN
cord-016293-pyb00pt5	914	29	mapping	map	VBG
cord-016293-pyb00pt5	914	30	genetic	genetic	JJ
cord-016293-pyb00pt5	914	31	diseases	disease	NNS
cord-016293-pyb00pt5	914	32	Separation	separation	NN
cord-016293-pyb00pt5	914	33	of	of	IN
cord-016293-pyb00pt5	914	34	DNA	dna	NN
cord-016293-pyb00pt5	914	35	restriction	restriction	NN
cord-016293-pyb00pt5	914	36	fragments	fragment	NNS
cord-016293-pyb00pt5	914	37	by	by	IN
cord-016293-pyb00pt5	914	38	high	high	JJ
cord-016293-pyb00pt5	914	39	performance	performance	NN
cord-016293-pyb00pt5	914	40	capillary	capillary	NN
cord-016293-pyb00pt5	914	41	electrophoresis	electrophoresis	NN
cord-016293-pyb00pt5	914	42	with	with	IN
cord-016293-pyb00pt5	914	43	low	low	JJ
cord-016293-pyb00pt5	914	44	and	and	CC
cord-016293-pyb00pt5	914	45	zero	zero	CD
cord-016293-pyb00pt5	914	46	crosslinked	crosslinke	VBN
cord-016293-pyb00pt5	914	47	polyacrylamide	polyacrylamide	NN
cord-016293-pyb00pt5	914	48	using	use	VBG
cord-016293-pyb00pt5	914	49	continuous	continuous	JJ
cord-016293-pyb00pt5	914	50	and	and	CC
cord-016293-pyb00pt5	914	51	pulsed	pulse	VBN
cord-016293-pyb00pt5	914	52	electric	electric	JJ
cord-016293-pyb00pt5	914	53	fields	field	NNS
cord-016293-pyb00pt5	914	54	Preimplantation	Preimplantation	NNP
cord-016293-pyb00pt5	914	55	and	and	CC
cord-016293-pyb00pt5	914	56	the	the	DT
cord-016293-pyb00pt5	914	57	'	'	``
cord-016293-pyb00pt5	914	58	new	new	JJ
cord-016293-pyb00pt5	914	59	'	'	''
cord-016293-pyb00pt5	914	60	genetics	genetic	NNS
cord-016293-pyb00pt5	914	61	A	a	DT
cord-016293-pyb00pt5	914	62	history	history	NN
cord-016293-pyb00pt5	914	63	human	human	JJ
cord-016293-pyb00pt5	914	64	genome	genome	NN
cord-016293-pyb00pt5	914	65	project	project	NN
cord-016293-pyb00pt5	915	1	It	-PRON-	PRP
cord-016293-pyb00pt5	915	2	ai	be	VBP
cord-016293-pyb00pt5	915	3	nt	not	RB
cord-016293-pyb00pt5	915	4	necessarily	necessarily	RB
cord-016293-pyb00pt5	915	5	so	so	RB
cord-016293-pyb00pt5	915	6	:	:	:
cord-016293-pyb00pt5	916	1	The	the	DT
cord-016293-pyb00pt5	916	2	dream	dream	NN
cord-016293-pyb00pt5	916	3	of	of	IN
cord-016293-pyb00pt5	916	4	the	the	DT
cord-016293-pyb00pt5	916	5	human	human	JJ
cord-016293-pyb00pt5	916	6	genome	genome	NN
cord-016293-pyb00pt5	916	7	and	and	CC
cord-016293-pyb00pt5	916	8	other	other	JJ
cord-016293-pyb00pt5	916	9	illusions	illusion	NNS
cord-016293-pyb00pt5	916	10	High	high	JJ
cord-016293-pyb00pt5	916	11	speed	speed	NN
cord-016293-pyb00pt5	916	12	DNA	dna	NN
cord-016293-pyb00pt5	916	13	sequencing	sequencing	NN
cord-016293-pyb00pt5	916	14	by	by	IN
cord-016293-pyb00pt5	916	15	capillary	capillary	JJ
cord-016293-pyb00pt5	916	16	electrophoresis	electrophoresis	NN
cord-016293-pyb00pt5	916	17	A	a	DT
cord-016293-pyb00pt5	916	18	strategy	strategy	NN
cord-016293-pyb00pt5	916	19	for	for	IN
cord-016293-pyb00pt5	916	20	sequencing	sequence	VBG
cord-016293-pyb00pt5	916	21	the	the	DT
cord-016293-pyb00pt5	916	22	genome	genome	NN
cord-016293-pyb00pt5	916	23	5	5	CD
cord-016293-pyb00pt5	916	24	years	year	NNS
cord-016293-pyb00pt5	916	25	early	early	JJ
cord-016293-pyb00pt5	916	26	Expression	expression	NN
cord-016293-pyb00pt5	916	27	of	of	IN
cord-016293-pyb00pt5	916	28	norwalk	norwalk	NNP
cord-016293-pyb00pt5	916	29	virus	virus	NNP
cord-016293-pyb00pt5	916	30	capsid	capsid	NN
cord-016293-pyb00pt5	916	31	protein	protein	NN
cord-016293-pyb00pt5	916	32	in	in	IN
cord-016293-pyb00pt5	916	33	transgenic	transgenic	JJ
cord-016293-pyb00pt5	916	34	tobacco	tobacco	NN
cord-016293-pyb00pt5	916	35	and	and	CC
cord-016293-pyb00pt5	916	36	potato	potato	NN
cord-016293-pyb00pt5	916	37	and	and	CC
cord-016293-pyb00pt5	916	38	its	-PRON-	PRP$
cord-016293-pyb00pt5	916	39	oral	oral	JJ
cord-016293-pyb00pt5	916	40	immunogenicity	immunogenicity	NN
cord-016293-pyb00pt5	916	41	in	in	IN
cord-016293-pyb00pt5	916	42	mice	mouse	NNS
cord-016293-pyb00pt5	916	43	Rapid	rapid	JJ
cord-016293-pyb00pt5	916	44	production	production	NN
cord-016293-pyb00pt5	916	45	of	of	IN
cord-016293-pyb00pt5	916	46	specific	specific	JJ
cord-016293-pyb00pt5	916	47	vaccines	vaccine	NNS
cord-016293-pyb00pt5	916	48	for	for	IN
cord-016293-pyb00pt5	916	49	lymphoma	lymphoma	NN
cord-016293-pyb00pt5	916	50	by	by	IN
cord-016293-pyb00pt5	916	51	expression	expression	NN
cord-016293-pyb00pt5	916	52	of	of	IN
cord-016293-pyb00pt5	916	53	the	the	DT
cord-016293-pyb00pt5	916	54	tumor	tumor	NN
cord-016293-pyb00pt5	916	55	-	-	HYPH
cord-016293-pyb00pt5	916	56	derived	derive	VBN
cord-016293-pyb00pt5	916	57	single	single	JJ
cord-016293-pyb00pt5	916	58	-	-	HYPH
cord-016293-pyb00pt5	916	59	chain	chain	NN
cord-016293-pyb00pt5	916	60	Fv	Fv	NNP
cord-016293-pyb00pt5	916	61	epitopes	epitope	NNS
cord-016293-pyb00pt5	916	62	in	in	IN
cord-016293-pyb00pt5	916	63	tobacco	tobacco	NN
cord-016293-pyb00pt5	916	64	plants	plant	NNS
cord-016293-pyb00pt5	916	65	Generation	generation	NN
cord-016293-pyb00pt5	916	66	and	and	CC
cord-016293-pyb00pt5	916	67	analysis	analysis	NN
cord-016293-pyb00pt5	916	68	of	of	IN
cord-016293-pyb00pt5	916	69	280,000	280,000	CD
cord-016293-pyb00pt5	916	70	human	human	NN
cord-016293-pyb00pt5	916	71	expressed	express	VBD
cord-016293-pyb00pt5	916	72	sequence	sequence	NN
cord-016293-pyb00pt5	916	73	tags	tags	NNP
cord-016293-pyb00pt5	916	74	National	National	NNP
cord-016293-pyb00pt5	916	75	Academy	Academy	NNP
cord-016293-pyb00pt5	916	76	of	of	IN
cord-016293-pyb00pt5	916	77	Sciences	Sciences	NNPS
cord-016293-pyb00pt5	916	78	.	.	.
cord-016293-pyb00pt5	917	1	Introduction	introduction	NN
cord-016293-pyb00pt5	917	2	of	of	IN
cord-016293-pyb00pt5	917	3	recombinant	recombinant	JJ
cord-016293-pyb00pt5	917	4	DNA	dna	NN
cord-016293-pyb00pt5	917	5	-	-	HYPH
cord-016293-pyb00pt5	917	6	engineered	engineer	VBN
cord-016293-pyb00pt5	917	7	organisms	organism	NNS
cord-016293-pyb00pt5	917	8	into	into	IN
cord-016293-pyb00pt5	917	9	the	the	DT
cord-016293-pyb00pt5	917	10	environment	environment	NN
cord-016293-pyb00pt5	917	11	:	:	:
cord-016293-pyb00pt5	917	12	key	key	JJ
cord-016293-pyb00pt5	917	13	issues	issue	NNS
cord-016293-pyb00pt5	917	14	Functional	Functional	NNP
cord-016293-pyb00pt5	917	15	Foods	Foods	NNPS
cord-016293-pyb00pt5	917	16	and	and	CC
cord-016293-pyb00pt5	917	17	Biopharmaceuticals	Biopharmaceuticals	NNPS
cord-016293-pyb00pt5	917	18	:	:	:
cord-016293-pyb00pt5	918	1	The	the	DT
cord-016293-pyb00pt5	918	2	Next	Next	NNP
cord-016293-pyb00pt5	918	3	Generation	Generation	NNP
cord-016293-pyb00pt5	918	4	of	of	IN
cord-016293-pyb00pt5	918	5	the	the	DT
cord-016293-pyb00pt5	918	6	GM	GM	NNP
cord-016293-pyb00pt5	918	7	Revolution	Revolution	NNP
cord-016293-pyb00pt5	918	8	in	in	IN
cord-016293-pyb00pt5	918	9	Let	let	VB
cord-016293-pyb00pt5	918	10	Them	-PRON-	PRP
cord-016293-pyb00pt5	918	11	Eat	eat	VB
cord-016293-pyb00pt5	918	12	Precaution	precaution	NN
cord-016293-pyb00pt5	918	13	Biotechnology	Biotechnology	NNP
cord-016293-pyb00pt5	918	14	:	:	:
cord-016293-pyb00pt5	918	15	A	a	DT
cord-016293-pyb00pt5	918	16	Review	Review	NNP
cord-016293-pyb00pt5	918	17	of	of	IN
cord-016293-pyb00pt5	918	18	Technological	Technological	NNP
cord-016293-pyb00pt5	918	19	Developments	Developments	NNPS
cord-016293-pyb00pt5	918	20	,	,	,
cord-016293-pyb00pt5	918	21	Publishers	Publishers	NNPS
cord-016293-pyb00pt5	918	22	Forfas	Forfas	NNP
cord-016293-pyb00pt5	918	23	Vitamin	vitamin	NN
cord-016293-pyb00pt5	918	24	-	-	HYPH
cord-016293-pyb00pt5	918	25	A	a	NN
cord-016293-pyb00pt5	918	26	and	and	CC
cord-016293-pyb00pt5	918	27	iron	iron	NN
cord-016293-pyb00pt5	918	28	-	-	HYPH
cord-016293-pyb00pt5	918	29	enriched	enrich	VBN
cord-016293-pyb00pt5	918	30	rices	rice	NNS
cord-016293-pyb00pt5	918	31	may	may	MD
cord-016293-pyb00pt5	918	32	hold	hold	VB
cord-016293-pyb00pt5	918	33	key	key	NN
cord-016293-pyb00pt5	918	34	to	to	IN
cord-016293-pyb00pt5	918	35	combating	combat	VBG
cord-016293-pyb00pt5	918	36	blindness	blindness	NN
cord-016293-pyb00pt5	918	37	and	and	CC
cord-016293-pyb00pt5	918	38	malnutrition	malnutrition	NN
cord-016293-pyb00pt5	918	39	:	:	:
cord-016293-pyb00pt5	918	40	a	a	DT
cord-016293-pyb00pt5	918	41	biotechnology	biotechnology	NN
cord-016293-pyb00pt5	918	42	advance	advance	NN
cord-016293-pyb00pt5	918	43	French	french	JJ
cord-016293-pyb00pt5	918	44	DNA	dna	NN
cord-016293-pyb00pt5	918	45	:	:	:
cord-016293-pyb00pt5	918	46	Trouble	trouble	NN
cord-016293-pyb00pt5	918	47	in	in	IN
cord-016293-pyb00pt5	918	48	Purgatory	Purgatory	NNP
cord-016293-pyb00pt5	918	49	Genome	Genome	NNP
cord-016293-pyb00pt5	918	50	:	:	:
cord-016293-pyb00pt5	918	51	The	the	DT
cord-016293-pyb00pt5	918	52	Autobiography	Autobiography	NNP
cord-016293-pyb00pt5	918	53	of	of	IN
cord-016293-pyb00pt5	918	54	a	a	DT
cord-016293-pyb00pt5	918	55	Species	species	NN
cord-016293-pyb00pt5	918	56	in	in	IN
cord-016293-pyb00pt5	918	57	23	23	CD
cord-016293-pyb00pt5	918	58	Chapters	Chapters	NNPS
cord-016293-pyb00pt5	918	59	Harper	Harper	NNP
cord-016293-pyb00pt5	918	60	Collins	Collins	NNP
cord-016293-pyb00pt5	918	61	Derivation	Derivation	NNP
cord-016293-pyb00pt5	918	62	of	of	IN
cord-016293-pyb00pt5	918	63	pluripotent	pluripotent	JJ
cord-016293-pyb00pt5	918	64	stem	stem	NN
cord-016293-pyb00pt5	918	65	cells	cell	NNS
cord-016293-pyb00pt5	918	66	from	from	IN
cord-016293-pyb00pt5	918	67	cultured	cultured	JJ
cord-016293-pyb00pt5	918	68	human	human	JJ
cord-016293-pyb00pt5	918	69	primordial	primordial	JJ
cord-016293-pyb00pt5	918	70	germ	germ	NN
cord-016293-pyb00pt5	918	71	cells	cell	NNS
cord-016293-pyb00pt5	918	72	Production	production	NN
cord-016293-pyb00pt5	918	73	of	of	IN
cord-016293-pyb00pt5	918	74	correctly	correctly	RB
cord-016293-pyb00pt5	918	75	processed	process	VBN
cord-016293-pyb00pt5	918	76	human	human	JJ
cord-016293-pyb00pt5	918	77	serum	serum	NN
cord-016293-pyb00pt5	918	78	albumin	albumin	NN
cord-016293-pyb00pt5	918	79	in	in	IN
cord-016293-pyb00pt5	918	80	transgenic	transgenic	JJ
cord-016293-pyb00pt5	918	81	plants	plant	NNS
cord-016293-pyb00pt5	918	82	High	high	JJ
cord-016293-pyb00pt5	918	83	-	-	HYPH
cord-016293-pyb00pt5	918	84	yield	yield	NN
cord-016293-pyb00pt5	918	85	production	production	NN
cord-016293-pyb00pt5	918	86	of	of	IN
cord-016293-pyb00pt5	918	87	a	a	DT
cord-016293-pyb00pt5	918	88	human	human	JJ
cord-016293-pyb00pt5	918	89	therapeutic	therapeutic	JJ
cord-016293-pyb00pt5	918	90	protein	protein	NN
cord-016293-pyb00pt5	918	91	in	in	IN
cord-016293-pyb00pt5	918	92	tobacco	tobacco	NN
cord-016293-pyb00pt5	918	93	chloroplasts	chloroplast	NNS
cord-016293-pyb00pt5	919	1	The	the	DT
cord-016293-pyb00pt5	919	2	common	common	JJ
cord-016293-pyb00pt5	919	3	thread	thread	NN
cord-016293-pyb00pt5	919	4	:	:	:
cord-016293-pyb00pt5	919	5	A	a	DT
cord-016293-pyb00pt5	919	6	story	story	NN
cord-016293-pyb00pt5	919	7	of	of	IN
cord-016293-pyb00pt5	919	8	science	science	NN
cord-016293-pyb00pt5	919	9	,	,	,
cord-016293-pyb00pt5	919	10	politics	politic	NNS
cord-016293-pyb00pt5	919	11	,	,	,
cord-016293-pyb00pt5	919	12	ethics	ethic	NNS
cord-016293-pyb00pt5	919	13	and	and	CC
cord-016293-pyb00pt5	919	14	the	the	DT
cord-016293-pyb00pt5	919	15	human	human	JJ
cord-016293-pyb00pt5	919	16	genome	genome	NN
cord-016293-pyb00pt5	919	17	Capillary	capillary	JJ
cord-016293-pyb00pt5	919	18	gel	gel	NN
cord-016293-pyb00pt5	919	19	electrophoresis	electrophoresis	NN
cord-016293-pyb00pt5	919	20	for	for	IN
cord-016293-pyb00pt5	919	21	DNA	dna	NN
cord-016293-pyb00pt5	919	22	sequencing	sequencing	NN
cord-016293-pyb00pt5	919	23	.	.	.
cord-016293-pyb00pt5	920	1	Laser	laser	NN
cord-016293-pyb00pt5	920	2	-	-	HYPH
cord-016293-pyb00pt5	920	3	induced	induce	VBN
cord-016293-pyb00pt5	920	4	fluorescence	fluorescence	NN
cord-016293-pyb00pt5	920	5	detection	detection	NN
cord-016293-pyb00pt5	920	6	with	with	IN
cord-016293-pyb00pt5	920	7	the	the	DT
cord-016293-pyb00pt5	920	8	sheath	sheath	NN
cord-016293-pyb00pt5	920	9	flow	flow	NN
cord-016293-pyb00pt5	920	10	cuvette	cuvette	NN
cord-016293-pyb00pt5	920	11	Production	production	NN
cord-016293-pyb00pt5	920	12	of	of	IN
cord-016293-pyb00pt5	920	13	functional	functional	JJ
cord-016293-pyb00pt5	920	14	human	human	JJ
cord-016293-pyb00pt5	920	15	alpha	alpha	NN
cord-016293-pyb00pt5	920	16	1-antitrypsin	1-antitrypsin	CD
cord-016293-pyb00pt5	920	17	by	by	IN
cord-016293-pyb00pt5	920	18	plant	plant	NN
cord-016293-pyb00pt5	920	19	cell	cell	NN
cord-016293-pyb00pt5	920	20	culture	culture	NN
cord-016293-pyb00pt5	920	21	Genetic	genetic	JJ
cord-016293-pyb00pt5	920	22	modification	modification	NN
cord-016293-pyb00pt5	920	23	of	of	IN
cord-016293-pyb00pt5	920	24	oils	oil	NNS
cord-016293-pyb00pt5	920	25	for	for	IN
cord-016293-pyb00pt5	920	26	improved	improved	JJ
cord-016293-pyb00pt5	920	27	health	health	NN
cord-016293-pyb00pt5	920	28	benefits	benefit	NNS
cord-016293-pyb00pt5	920	29	,	,	,
cord-016293-pyb00pt5	920	30	Presentation	presentation	NN
cord-016293-pyb00pt5	920	31	at	at	IN
cord-016293-pyb00pt5	920	32	conference	conference	NN
cord-016293-pyb00pt5	920	33	,	,	,
cord-016293-pyb00pt5	920	34	Dietary	dietary	JJ
cord-016293-pyb00pt5	920	35	Fatty	fatty	JJ
cord-016293-pyb00pt5	920	36	Acids	acid	NNS
cord-016293-pyb00pt5	920	37	and	and	CC
cord-016293-pyb00pt5	920	38	Cardiovascular	Cardiovascular	NNP
cord-016293-pyb00pt5	920	39	Health	Health	NNP
cord-016293-pyb00pt5	920	40	:	:	:
cord-016293-pyb00pt5	920	41	Dietary	dietary	JJ
cord-016293-pyb00pt5	920	42	Recommendations	Recommendations	NNPS
cord-016293-pyb00pt5	920	43	for	for	IN
cord-016293-pyb00pt5	920	44	Fatty	fatty	JJ
cord-016293-pyb00pt5	920	45	Acids	acid	NNS
cord-016293-pyb00pt5	921	1	:	:	:
cord-016293-pyb00pt5	921	2	Is	be	VBZ
cord-016293-pyb00pt5	921	3	There	there	EX
cord-016293-pyb00pt5	921	4	Ample	ample	JJ
cord-016293-pyb00pt5	921	5	Evidence	evidence	NN
cord-016293-pyb00pt5	921	6	?	?	.
cord-016293-pyb00pt5	922	1	Stable	stable	JJ
cord-016293-pyb00pt5	922	2	accumulation	accumulation	NN
cord-016293-pyb00pt5	922	3	of	of	IN
cord-016293-pyb00pt5	922	4	Aspergillus	Aspergillus	NNP
cord-016293-pyb00pt5	922	5	niger	niger	NNP
cord-016293-pyb00pt5	922	6	phytase	phytase	NN
cord-016293-pyb00pt5	922	7	in	in	IN
cord-016293-pyb00pt5	922	8	transgenic	transgenic	JJ
cord-016293-pyb00pt5	922	9	tobacco	tobacco	NN
cord-016293-pyb00pt5	922	10	leaves	leave	VBZ
cord-016293-pyb00pt5	922	11	Antenatal	Antenatal	NNP
cord-016293-pyb00pt5	922	12	maternal	maternal	JJ
cord-016293-pyb00pt5	922	13	serum	serum	NN
cord-016293-pyb00pt5	922	14	screening	screening	NN
cord-016293-pyb00pt5	922	15	for	for	IN
cord-016293-pyb00pt5	922	16	Down	Down	NNP
cord-016293-pyb00pt5	922	17	's	's	POS
cord-016293-pyb00pt5	922	18	syndrome	syndrome	NN
cord-016293-pyb00pt5	922	19	:	:	:
cord-016293-pyb00pt5	922	20	results	result	NNS
cord-016293-pyb00pt5	922	21	of	of	IN
cord-016293-pyb00pt5	922	22	a	a	DT
cord-016293-pyb00pt5	922	23	demonstration	demonstration	NN
cord-016293-pyb00pt5	922	24	project	project	NN
cord-016293-pyb00pt5	922	25	Viable	viable	JJ
cord-016293-pyb00pt5	922	26	offspring	offspring	NN
cord-016293-pyb00pt5	922	27	derived	derive	VBN
cord-016293-pyb00pt5	922	28	from	from	IN
cord-016293-pyb00pt5	922	29	fetal	fetal	JJ
cord-016293-pyb00pt5	922	30	and	and	CC
cord-016293-pyb00pt5	922	31	adult	adult	NN
cord-016293-pyb00pt5	922	32	mammalian	mammalian	JJ
cord-016293-pyb00pt5	922	33	cells	cell	NNS