id sid tid token lemma pos cord-022053-idft1p6d 1 1 key key NN cord-022053-idft1p6d 1 2 : : : cord-022053-idft1p6d 1 3 cord-022053-idft1p6d cord-022053-idft1p6d ADD cord-022053-idft1p6d 2 1 authors author NNS cord-022053-idft1p6d 2 2 : : : cord-022053-idft1p6d 2 3 Pecora Pecora NNP cord-022053-idft1p6d 2 4 , , , cord-022053-idft1p6d 2 5 Nicole Nicole NNP cord-022053-idft1p6d 2 6 ; ; : cord-022053-idft1p6d 2 7 Milner Milner NNP cord-022053-idft1p6d 2 8 , , , cord-022053-idft1p6d 2 9 Danny Danny NNP cord-022053-idft1p6d 2 10 A. a. NN cord-022053-idft1p6d 2 11 title title NN cord-022053-idft1p6d 2 12 : : : cord-022053-idft1p6d 2 13 New New NNP cord-022053-idft1p6d 2 14 Technologies Technologies NNPS cord-022053-idft1p6d 2 15 for for IN cord-022053-idft1p6d 2 16 the the DT cord-022053-idft1p6d 2 17 Diagnosis Diagnosis NNP cord-022053-idft1p6d 2 18 of of IN cord-022053-idft1p6d 2 19 Infection Infection NNP cord-022053-idft1p6d 2 20 date date NN cord-022053-idft1p6d 2 21 : : : cord-022053-idft1p6d 2 22 2017 2017 CD cord-022053-idft1p6d 2 23 - - HYPH cord-022053-idft1p6d 2 24 07 07 CD cord-022053-idft1p6d 2 25 - - SYM cord-022053-idft1p6d 2 26 21 21 CD cord-022053-idft1p6d 2 27 journal journal NN cord-022053-idft1p6d 2 28 : : : cord-022053-idft1p6d 2 29 Diagnostic Diagnostic NNP cord-022053-idft1p6d 2 30 Pathology Pathology NNP cord-022053-idft1p6d 2 31 of of IN cord-022053-idft1p6d 2 32 Infectious Infectious NNP cord-022053-idft1p6d 2 33 Disease Disease NNP cord-022053-idft1p6d 2 34 DOI DOI NNP cord-022053-idft1p6d 2 35 : : : cord-022053-idft1p6d 3 1 10.1016 10.1016 CD cord-022053-idft1p6d 3 2 / / SYM cord-022053-idft1p6d 3 3 b978 b978 NNP cord-022053-idft1p6d 3 4 - - HYPH cord-022053-idft1p6d 3 5 0 0 CD cord-022053-idft1p6d 3 6 - - HYPH cord-022053-idft1p6d 3 7 323 323 CD cord-022053-idft1p6d 3 8 - - HYPH cord-022053-idft1p6d 3 9 44585 44585 CD cord-022053-idft1p6d 3 10 - - HYPH cord-022053-idft1p6d 3 11 6.00006 6.00006 CD cord-022053-idft1p6d 3 12 - - SYM cord-022053-idft1p6d 3 13 0 0 CD cord-022053-idft1p6d 3 14 sha sha NN cord-022053-idft1p6d 3 15 : : : cord-022053-idft1p6d 3 16 e6d4a58ec347043bf1de03ce82f2a0c93371be18 e6d4a58ec347043bf1de03ce82f2a0c93371be18 . cord-022053-idft1p6d 4 1 doc_id doc_id CD cord-022053-idft1p6d 4 2 : : : cord-022053-idft1p6d 5 1 22053 22053 CD cord-022053-idft1p6d 5 2 cord_uid cord_uid NNS cord-022053-idft1p6d 5 3 : : : cord-022053-idft1p6d 6 1 idft1p6d idft1p6d NNP cord-022053-idft1p6d 7 1 nan nan NNP cord-022053-idft1p6d 7 2 FilmArray FilmArray NNP cord-022053-idft1p6d 7 3 ( ( -LRB- cord-022053-idft1p6d 7 4 BioFire BioFire NNP cord-022053-idft1p6d 7 5 / / SYM cord-022053-idft1p6d 7 6 BioMérieux BioMérieux NNP cord-022053-idft1p6d 7 7 ) ) -RRB- cord-022053-idft1p6d 8 1 BD BD NNP cord-022053-idft1p6d 8 2 Max Max NNP cord-022053-idft1p6d 8 3 ( ( -LRB- cord-022053-idft1p6d 8 4 BD BD NNP cord-022053-idft1p6d 8 5 Diagnostics Diagnostics NNP cord-022053-idft1p6d 8 6 ) ) -RRB- cord-022053-idft1p6d 9 1 Luminex Luminex NNP cord-022053-idft1p6d 9 2 Next Next NNP cord-022053-idft1p6d 9 3 - - HYPH cord-022053-idft1p6d 9 4 Generation Generation NNP cord-022053-idft1p6d 9 5 Sequencing Sequencing NNP cord-022053-idft1p6d 9 6 Conclusion Conclusion NNP cord-022053-idft1p6d 9 7 T t NN cord-022053-idft1p6d 9 8 he -PRON- PRP cord-022053-idft1p6d 10 1 clinical clinical JJ cord-022053-idft1p6d 10 2 microbiology microbiology NN cord-022053-idft1p6d 10 3 laboratory laboratory NN cord-022053-idft1p6d 10 4 is be VBZ cord-022053-idft1p6d 10 5 constantly constantly RB cord-022053-idft1p6d 10 6 evolving evolve VBG cord-022053-idft1p6d 10 7 and and CC cord-022053-idft1p6d 10 8 progressing progress VBG cord-022053-idft1p6d 10 9 . . . cord-022053-idft1p6d 11 1 New new JJ cord-022053-idft1p6d 11 2 technologies technology NNS cord-022053-idft1p6d 11 3 have have VBP cord-022053-idft1p6d 11 4 revolutionized revolutionize VBN cord-022053-idft1p6d 11 5 the the DT cord-022053-idft1p6d 11 6 characterization characterization NN cord-022053-idft1p6d 11 7 and and CC cord-022053-idft1p6d 11 8 diagnosis diagnosis NN cord-022053-idft1p6d 11 9 of of IN cord-022053-idft1p6d 11 10 pathogens pathogen NNS cord-022053-idft1p6d 11 11 . . . cord-022053-idft1p6d 12 1 The the DT cord-022053-idft1p6d 12 2 purpose purpose NN cord-022053-idft1p6d 12 3 of of IN cord-022053-idft1p6d 12 4 this this DT cord-022053-idft1p6d 12 5 chapter chapter NN cord-022053-idft1p6d 12 6 is be VBZ cord-022053-idft1p6d 12 7 to to TO cord-022053-idft1p6d 12 8 review review VB cord-022053-idft1p6d 12 9 the the DT cord-022053-idft1p6d 12 10 features feature NNS cord-022053-idft1p6d 12 11 , , , cord-022053-idft1p6d 12 12 benefits benefit NNS cord-022053-idft1p6d 12 13 , , , cord-022053-idft1p6d 12 14 and and CC cord-022053-idft1p6d 12 15 limitations limitation NNS cord-022053-idft1p6d 12 16 of of IN cord-022053-idft1p6d 12 17 some some DT cord-022053-idft1p6d 12 18 of of IN cord-022053-idft1p6d 12 19 the the DT cord-022053-idft1p6d 12 20 key key JJ cord-022053-idft1p6d 12 21 new new JJ cord-022053-idft1p6d 12 22 methodologies methodology NNS cord-022053-idft1p6d 12 23 in in IN cord-022053-idft1p6d 12 24 infectious infectious JJ cord-022053-idft1p6d 12 25 disease disease NN cord-022053-idft1p6d 12 26 diagnostics diagnostic NNS cord-022053-idft1p6d 12 27 . . . cord-022053-idft1p6d 13 1 The the DT cord-022053-idft1p6d 13 2 chapter chapter NN cord-022053-idft1p6d 13 3 will will MD cord-022053-idft1p6d 13 4 be be VB cord-022053-idft1p6d 13 5 organized organize VBN cord-022053-idft1p6d 13 6 by by IN cord-022053-idft1p6d 13 7 technology technology NN cord-022053-idft1p6d 13 8 . . . cord-022053-idft1p6d 14 1 New new JJ cord-022053-idft1p6d 14 2 technologies technology NNS cord-022053-idft1p6d 14 3 have have VBP cord-022053-idft1p6d 14 4 the the DT cord-022053-idft1p6d 14 5 most most JJS cord-022053-idft1p6d 14 6 impact impact NN cord-022053-idft1p6d 14 7 in in IN cord-022053-idft1p6d 14 8 the the DT cord-022053-idft1p6d 14 9 fields field NNS cord-022053-idft1p6d 14 10 of of IN cord-022053-idft1p6d 14 11 bacteriology bacteriology NN cord-022053-idft1p6d 14 12 and and CC cord-022053-idft1p6d 14 13 virology virology NN cord-022053-idft1p6d 14 14 , , , cord-022053-idft1p6d 14 15 but but CC cord-022053-idft1p6d 14 16 there there EX cord-022053-idft1p6d 14 17 are be VBP cord-022053-idft1p6d 14 18 also also RB cord-022053-idft1p6d 14 19 promising promise VBG cord-022053-idft1p6d 14 20 new new JJ cord-022053-idft1p6d 14 21 developments development NNS cord-022053-idft1p6d 14 22 in in IN cord-022053-idft1p6d 14 23 mycology mycology NN cord-022053-idft1p6d 14 24 and and CC cord-022053-idft1p6d 14 25 parasitology parasitology NN cord-022053-idft1p6d 14 26 . . . cord-022053-idft1p6d 15 1 The the DT cord-022053-idft1p6d 15 2 mainstay mainstay NN cord-022053-idft1p6d 15 3 of of IN cord-022053-idft1p6d 15 4 bacterial bacterial JJ cord-022053-idft1p6d 15 5 and and CC cord-022053-idft1p6d 15 6 mycologic mycologic JJ cord-022053-idft1p6d 15 7 diagnosis diagnosis NN cord-022053-idft1p6d 15 8 continues continue VBZ cord-022053-idft1p6d 15 9 to to TO cord-022053-idft1p6d 15 10 be be VB cord-022053-idft1p6d 15 11 culture culture NN cord-022053-idft1p6d 15 12 by by IN cord-022053-idft1p6d 15 13 traditional traditional JJ cord-022053-idft1p6d 15 14 techniques technique NNS cord-022053-idft1p6d 15 15 , , , cord-022053-idft1p6d 15 16 although although IN cord-022053-idft1p6d 15 17 increasingly increasingly RB cord-022053-idft1p6d 15 18 these these DT cord-022053-idft1p6d 15 19 are be VBP cord-022053-idft1p6d 15 20 automated automate VBN cord-022053-idft1p6d 15 21 ( ( -LRB- cord-022053-idft1p6d 15 22 Fig fig NN cord-022053-idft1p6d 15 23 . . . cord-022053-idft1p6d 15 24 6.1 6.1 CD cord-022053-idft1p6d 15 25 ) ) -RRB- cord-022053-idft1p6d 15 26 . . . cord-022053-idft1p6d 16 1 After after IN cord-022053-idft1p6d 16 2 an an DT cord-022053-idft1p6d 16 3 organism organism NN cord-022053-idft1p6d 16 4 is be VBZ cord-022053-idft1p6d 16 5 isolated isolate VBN cord-022053-idft1p6d 16 6 , , , cord-022053-idft1p6d 16 7 however however RB cord-022053-idft1p6d 16 8 , , , cord-022053-idft1p6d 16 9 a a DT cord-022053-idft1p6d 16 10 host host NN cord-022053-idft1p6d 16 11 of of IN cord-022053-idft1p6d 16 12 newer new JJR cord-022053-idft1p6d 16 13 diagnostics diagnostic NNS cord-022053-idft1p6d 16 14 have have VBP cord-022053-idft1p6d 16 15 enhanced enhance VBN cord-022053-idft1p6d 16 16 , , , cord-022053-idft1p6d 16 17 and and CC cord-022053-idft1p6d 16 18 in in IN cord-022053-idft1p6d 16 19 some some DT cord-022053-idft1p6d 16 20 cases case NNS cord-022053-idft1p6d 16 21 replaced replace VBN cord-022053-idft1p6d 16 22 , , , cord-022053-idft1p6d 16 23 the the DT cord-022053-idft1p6d 16 24 biochemical biochemical JJ cord-022053-idft1p6d 16 25 test test NN cord-022053-idft1p6d 16 26 algorithm algorithm NN cord-022053-idft1p6d 16 27 that that WDT cord-022053-idft1p6d 16 28 has have VBZ cord-022053-idft1p6d 16 29 historically historically RB cord-022053-idft1p6d 16 30 defined define VBN cord-022053-idft1p6d 16 31 clinical clinical JJ cord-022053-idft1p6d 16 32 bacteriology bacteriology NN cord-022053-idft1p6d 16 33 . . . cord-022053-idft1p6d 17 1 The the DT cord-022053-idft1p6d 17 2 advent advent NN cord-022053-idft1p6d 17 3 of of IN cord-022053-idft1p6d 17 4 matrix matrix NN cord-022053-idft1p6d 17 5 - - HYPH cord-022053-idft1p6d 17 6 assisted assist VBN cord-022053-idft1p6d 17 7 laser laser NN cord-022053-idft1p6d 17 8 desorption desorption NN cord-022053-idft1p6d 17 9 time time NN cord-022053-idft1p6d 17 10 of of IN cord-022053-idft1p6d 17 11 flight flight NN cord-022053-idft1p6d 17 12 ( ( -LRB- cord-022053-idft1p6d 17 13 MALDI MALDI NNP cord-022053-idft1p6d 17 14 - - HYPH cord-022053-idft1p6d 17 15 TOF TOF NNP cord-022053-idft1p6d 17 16 ) ) -RRB- cord-022053-idft1p6d 17 17 mass mass NN cord-022053-idft1p6d 17 18 spectrometry spectrometry NN cord-022053-idft1p6d 17 19 is be VBZ cord-022053-idft1p6d 17 20 one one CD cord-022053-idft1p6d 17 21 of of IN cord-022053-idft1p6d 17 22 the the DT cord-022053-idft1p6d 17 23 main main JJ cord-022053-idft1p6d 17 24 forces force NNS cord-022053-idft1p6d 17 25 behind behind IN cord-022053-idft1p6d 17 26 this this DT cord-022053-idft1p6d 17 27 shift shift NN cord-022053-idft1p6d 17 28 , , , cord-022053-idft1p6d 17 29 allowing allow VBG cord-022053-idft1p6d 17 30 a a DT cord-022053-idft1p6d 17 31 cultured cultured JJ cord-022053-idft1p6d 17 32 organism organism NN cord-022053-idft1p6d 17 33 to to TO cord-022053-idft1p6d 17 34 be be VB cord-022053-idft1p6d 17 35 identified identify VBN cord-022053-idft1p6d 17 36 in in IN cord-022053-idft1p6d 17 37 minutes minute NNS cord-022053-idft1p6d 17 38 instead instead RB cord-022053-idft1p6d 17 39 of of IN cord-022053-idft1p6d 17 40 hours hour NNS cord-022053-idft1p6d 17 41 to to IN cord-022053-idft1p6d 17 42 days day NNS cord-022053-idft1p6d 17 43 or or CC cord-022053-idft1p6d 17 44 even even RB cord-022053-idft1p6d 17 45 weeks week NNS cord-022053-idft1p6d 17 46 in in IN cord-022053-idft1p6d 17 47 the the DT cord-022053-idft1p6d 17 48 case case NN cord-022053-idft1p6d 17 49 of of IN cord-022053-idft1p6d 17 50 very very RB cord-022053-idft1p6d 17 51 slow slow RB cord-022053-idft1p6d 17 52 - - HYPH cord-022053-idft1p6d 17 53 growing grow VBG cord-022053-idft1p6d 17 54 organisms organism NNS cord-022053-idft1p6d 17 55 , , , cord-022053-idft1p6d 17 56 such such JJ cord-022053-idft1p6d 17 57 as as IN cord-022053-idft1p6d 17 58 mycobacteria mycobacterium NNS cord-022053-idft1p6d 17 59 . . . cord-022053-idft1p6d 18 1 Although although IN cord-022053-idft1p6d 18 2 still still RB cord-022053-idft1p6d 18 3 not not RB cord-022053-idft1p6d 18 4 in in IN cord-022053-idft1p6d 18 5 routine routine JJ cord-022053-idft1p6d 18 6 clinical clinical JJ cord-022053-idft1p6d 18 7 use use NN cord-022053-idft1p6d 18 8 , , , cord-022053-idft1p6d 18 9 the the DT cord-022053-idft1p6d 18 10 application application NN cord-022053-idft1p6d 18 11 of of IN cord-022053-idft1p6d 18 12 MALDI MALDI NNP cord-022053-idft1p6d 18 13 - - HYPH cord-022053-idft1p6d 18 14 TOF TOF NNP cord-022053-idft1p6d 18 15 to to TO cord-022053-idft1p6d 18 16 direct direct JJ cord-022053-idft1p6d 18 17 patient patient NN cord-022053-idft1p6d 18 18 samples sample NNS cord-022053-idft1p6d 18 19 , , , cord-022053-idft1p6d 18 20 such such JJ cord-022053-idft1p6d 18 21 as as IN cord-022053-idft1p6d 18 22 blood blood NN cord-022053-idft1p6d 18 23 and and CC cord-022053-idft1p6d 18 24 urine urine NN cord-022053-idft1p6d 18 25 , , , cord-022053-idft1p6d 18 26 and and CC cord-022053-idft1p6d 18 27 applications application NNS cord-022053-idft1p6d 18 28 such such JJ cord-022053-idft1p6d 18 29 as as IN cord-022053-idft1p6d 18 30 antibiotic antibiotic JJ cord-022053-idft1p6d 18 31 resistance resistance NN cord-022053-idft1p6d 18 32 are be VBP cord-022053-idft1p6d 18 33 exciting exciting JJ cord-022053-idft1p6d 18 34 developments development NNS cord-022053-idft1p6d 18 35 . . . cord-022053-idft1p6d 19 1 Beyond beyond IN cord-022053-idft1p6d 19 2 bacteria bacteria NNS cord-022053-idft1p6d 19 3 , , , cord-022053-idft1p6d 19 4 MALDI MALDI NNP cord-022053-idft1p6d 19 5 - - HYPH cord-022053-idft1p6d 19 6 TOF TOF NNP cord-022053-idft1p6d 19 7 is be VBZ cord-022053-idft1p6d 19 8 becoming become VBG cord-022053-idft1p6d 19 9 established establish VBN cord-022053-idft1p6d 19 10 for for IN cord-022053-idft1p6d 19 11 the the DT cord-022053-idft1p6d 19 12 identification identification NN cord-022053-idft1p6d 19 13 of of IN cord-022053-idft1p6d 19 14 yeasts yeast NNS cord-022053-idft1p6d 19 15 and and CC cord-022053-idft1p6d 19 16 , , , cord-022053-idft1p6d 19 17 with with IN cord-022053-idft1p6d 19 18 the the DT cord-022053-idft1p6d 19 19 development development NN cord-022053-idft1p6d 19 20 of of IN cord-022053-idft1p6d 19 21 more more RBR cord-022053-idft1p6d 19 22 extensive extensive JJ cord-022053-idft1p6d 19 23 and and CC cord-022053-idft1p6d 19 24 higher high JJR cord-022053-idft1p6d 19 25 quality quality NN cord-022053-idft1p6d 19 26 libraries library NNS cord-022053-idft1p6d 19 27 , , , cord-022053-idft1p6d 19 28 is be VBZ cord-022053-idft1p6d 19 29 expected expect VBN cord-022053-idft1p6d 19 30 to to TO cord-022053-idft1p6d 19 31 also also RB cord-022053-idft1p6d 19 32 do do VB cord-022053-idft1p6d 19 33 so so RB cord-022053-idft1p6d 19 34 for for IN cord-022053-idft1p6d 19 35 other other JJ cord-022053-idft1p6d 19 36 fungi fungus NNS cord-022053-idft1p6d 19 37 . . . cord-022053-idft1p6d 20 1 Nucleic nucleic JJ cord-022053-idft1p6d 20 2 acid acid NN cord-022053-idft1p6d 20 3 - - HYPH cord-022053-idft1p6d 20 4 based base VBN cord-022053-idft1p6d 20 5 technologies technology NNS cord-022053-idft1p6d 20 6 have have VBP cord-022053-idft1p6d 20 7 also also RB cord-022053-idft1p6d 20 8 had have VBN cord-022053-idft1p6d 20 9 a a DT cord-022053-idft1p6d 20 10 big big JJ cord-022053-idft1p6d 20 11 impact impact NN cord-022053-idft1p6d 20 12 . . . cord-022053-idft1p6d 21 1 In in IN cord-022053-idft1p6d 21 2 particular particular JJ cord-022053-idft1p6d 21 3 , , , cord-022053-idft1p6d 21 4 there there EX cord-022053-idft1p6d 21 5 are be VBP cord-022053-idft1p6d 21 6 a a DT cord-022053-idft1p6d 21 7 growing grow VBG cord-022053-idft1p6d 21 8 number number NN cord-022053-idft1p6d 21 9 of of IN cord-022053-idft1p6d 21 10 test test NN cord-022053-idft1p6d 21 11 platforms platform NNS cord-022053-idft1p6d 21 12 that that WDT cord-022053-idft1p6d 21 13 provide provide VBP cord-022053-idft1p6d 21 14 rapid rapid JJ cord-022053-idft1p6d 21 15 diagnostics diagnostic NNS cord-022053-idft1p6d 21 16 directly directly RB cord-022053-idft1p6d 21 17 from from IN cord-022053-idft1p6d 21 18 primary primary JJ cord-022053-idft1p6d 21 19 specimens specimen NNS cord-022053-idft1p6d 21 20 . . . cord-022053-idft1p6d 22 1 Many many JJ cord-022053-idft1p6d 22 2 of of IN cord-022053-idft1p6d 22 3 these these DT cord-022053-idft1p6d 22 4 are be VBP cord-022053-idft1p6d 22 5 multiplexed multiplexe VBN cord-022053-idft1p6d 22 6 to to TO cord-022053-idft1p6d 22 7 look look VB cord-022053-idft1p6d 22 8 at at IN cord-022053-idft1p6d 22 9 several several JJ cord-022053-idft1p6d 22 10 pathogens pathogen NNS cord-022053-idft1p6d 22 11 at at IN cord-022053-idft1p6d 22 12 one one CD cord-022053-idft1p6d 22 13 time time NN cord-022053-idft1p6d 22 14 . . . cord-022053-idft1p6d 23 1 The the DT cord-022053-idft1p6d 23 2 sequencing sequencing NN cord-022053-idft1p6d 23 3 of of IN cord-022053-idft1p6d 23 4 the the DT cord-022053-idft1p6d 23 5 regions region NNS cord-022053-idft1p6d 23 6 of of IN cord-022053-idft1p6d 23 7 ribosomal ribosomal JJ cord-022053-idft1p6d 23 8 RNA RNA NNP cord-022053-idft1p6d 23 9 ( ( -LRB- cord-022053-idft1p6d 23 10 rRNA rRNA NNP cord-022053-idft1p6d 23 11 ) ) -RRB- cord-022053-idft1p6d 23 12 , , , cord-022053-idft1p6d 23 13 such such JJ cord-022053-idft1p6d 23 14 as as IN cord-022053-idft1p6d 23 15 the the DT cord-022053-idft1p6d 23 16 16S 16S NNP cord-022053-idft1p6d 23 17 rRNA rrna NN cord-022053-idft1p6d 23 18 gene gene NN cord-022053-idft1p6d 23 19 in in IN cord-022053-idft1p6d 23 20 bacteria bacteria NNS cord-022053-idft1p6d 23 21 , , , cord-022053-idft1p6d 23 22 already already RB cord-022053-idft1p6d 23 23 considered consider VBN cord-022053-idft1p6d 23 24 the the DT cord-022053-idft1p6d 23 25 gold gold JJ cord-022053-idft1p6d 23 26 standard standard NN cord-022053-idft1p6d 23 27 for for IN cord-022053-idft1p6d 23 28 bacterial bacterial JJ cord-022053-idft1p6d 23 29 identification identification NN cord-022053-idft1p6d 23 30 , , , cord-022053-idft1p6d 23 31 is be VBZ cord-022053-idft1p6d 23 32 entering enter VBG cord-022053-idft1p6d 23 33 more more JJR cord-022053-idft1p6d 23 34 and and CC cord-022053-idft1p6d 23 35 more more RBR cord-022053-idft1p6d 23 36 into into IN cord-022053-idft1p6d 23 37 clinical clinical JJ cord-022053-idft1p6d 23 38 diagnostics diagnostic NNS cord-022053-idft1p6d 23 39 ( ( -LRB- cord-022053-idft1p6d 23 40 Fig fig NN cord-022053-idft1p6d 23 41 . . . cord-022053-idft1p6d 23 42 6.2 6.2 CD cord-022053-idft1p6d 23 43 ) ) -RRB- cord-022053-idft1p6d 23 44 . . . cord-022053-idft1p6d 24 1 Similarly similarly RB cord-022053-idft1p6d 24 2 , , , cord-022053-idft1p6d 24 3 the the DT cord-022053-idft1p6d 24 4 routine routine JJ cord-022053-idft1p6d 24 5 sequencing sequencing NN cord-022053-idft1p6d 24 6 of of IN cord-022053-idft1p6d 24 7 the the DT cord-022053-idft1p6d 24 8 intergenic intergenic JJ cord-022053-idft1p6d 24 9 transcribed transcribe VBN cord-022053-idft1p6d 24 10 spacer spacer NN cord-022053-idft1p6d 24 11 ( ( -LRB- cord-022053-idft1p6d 24 12 ITS its PRP$ cord-022053-idft1p6d 24 13 ) ) -RRB- cord-022053-idft1p6d 24 14 and and CC cord-022053-idft1p6d 24 15 28S 28S NNP cord-022053-idft1p6d 24 16 rRNA rRNA NNP cord-022053-idft1p6d 24 17 regions region NNS cord-022053-idft1p6d 24 18 in in IN cord-022053-idft1p6d 24 19 fungi fungus NNS cord-022053-idft1p6d 24 20 is be VBZ cord-022053-idft1p6d 24 21 a a DT cord-022053-idft1p6d 24 22 welcome welcome JJ cord-022053-idft1p6d 24 23 addition addition NN cord-022053-idft1p6d 24 24 to to IN cord-022053-idft1p6d 24 25 current current JJ cord-022053-idft1p6d 24 26 laborious laborious JJ cord-022053-idft1p6d 24 27 and and CC cord-022053-idft1p6d 24 28 morphology morphology NN cord-022053-idft1p6d 24 29 - - HYPH cord-022053-idft1p6d 24 30 heavy heavy JJ cord-022053-idft1p6d 24 31 techniques technique NNS cord-022053-idft1p6d 24 32 for for IN cord-022053-idft1p6d 24 33 diagnosing diagnose VBG cord-022053-idft1p6d 24 34 fungal fungal JJ cord-022053-idft1p6d 24 35 illnesses illness NNS cord-022053-idft1p6d 24 36 . . . cord-022053-idft1p6d 25 1 The the DT cord-022053-idft1p6d 25 2 entry entry NN cord-022053-idft1p6d 25 3 of of IN cord-022053-idft1p6d 25 4 next next JJ cord-022053-idft1p6d 25 5 - - HYPH cord-022053-idft1p6d 25 6 generation generation NN cord-022053-idft1p6d 25 7 sequencing sequencing NN cord-022053-idft1p6d 25 8 ( ( -LRB- cord-022053-idft1p6d 25 9 NGS NGS NNP cord-022053-idft1p6d 25 10 ) ) -RRB- cord-022053-idft1p6d 25 11 into into IN cord-022053-idft1p6d 25 12 clinical clinical JJ cord-022053-idft1p6d 25 13 microbiology microbiology NN cord-022053-idft1p6d 25 14 has have VBZ cord-022053-idft1p6d 25 15 also also RB cord-022053-idft1p6d 25 16 had have VBN cord-022053-idft1p6d 25 17 a a DT cord-022053-idft1p6d 25 18 dramatic dramatic JJ cord-022053-idft1p6d 25 19 effect effect NN cord-022053-idft1p6d 25 20 on on IN cord-022053-idft1p6d 25 21 both both CC cord-022053-idft1p6d 25 22 the the DT cord-022053-idft1p6d 25 23 profiling profiling NN cord-022053-idft1p6d 25 24 of of IN cord-022053-idft1p6d 25 25 individual individual JJ cord-022053-idft1p6d 25 26 specimens specimen NNS cord-022053-idft1p6d 25 27 ( ( -LRB- cord-022053-idft1p6d 25 28 i.e. i.e. FW cord-022053-idft1p6d 25 29 , , , cord-022053-idft1p6d 25 30 members member NNS cord-022053-idft1p6d 25 31 of of IN cord-022053-idft1p6d 25 32 a a DT cord-022053-idft1p6d 25 33 potential potential JJ cord-022053-idft1p6d 25 34 outbreak outbreak NN cord-022053-idft1p6d 25 35 or or CC cord-022053-idft1p6d 25 36 highly highly RB cord-022053-idft1p6d 25 37 drug drug NN cord-022053-idft1p6d 25 38 resistant resistant JJ cord-022053-idft1p6d 25 39 strains strain NNS cord-022053-idft1p6d 25 40 ) ) -RRB- cord-022053-idft1p6d 25 41 as as RB cord-022053-idft1p6d 25 42 well well RB cord-022053-idft1p6d 25 43 as as IN cord-022053-idft1p6d 25 44 communities community NNS cord-022053-idft1p6d 25 45 ( ( -LRB- cord-022053-idft1p6d 25 46 i.e. i.e. FW cord-022053-idft1p6d 25 47 , , , cord-022053-idft1p6d 25 48 microbiome microbiome NN cord-022053-idft1p6d 25 49 analysis analysis NN cord-022053-idft1p6d 25 50 in in IN cord-022053-idft1p6d 25 51 health health NN cord-022053-idft1p6d 25 52 and and CC cord-022053-idft1p6d 25 53 disease disease NN cord-022053-idft1p6d 25 54 ) ) -RRB- cord-022053-idft1p6d 25 55 . . . cord-022053-idft1p6d 26 1 Finally finally RB cord-022053-idft1p6d 26 2 , , , cord-022053-idft1p6d 26 3 the the DT cord-022053-idft1p6d 26 4 emerging emerge VBG cord-022053-idft1p6d 26 5 technology technology NN cord-022053-idft1p6d 26 6 of of IN cord-022053-idft1p6d 26 7 polymerase polymerase NN cord-022053-idft1p6d 26 8 chain chain NN cord-022053-idft1p6d 26 9 reaction reaction NN cord-022053-idft1p6d 26 10 ( ( -LRB- cord-022053-idft1p6d 26 11 PCR)-electrospray pcr)-electrospray JJ cord-022053-idft1p6d 26 12 ionization ionization NN cord-022053-idft1p6d 26 13 ( ( -LRB- cord-022053-idft1p6d 26 14 ESI ESI NNP cord-022053-idft1p6d 26 15 ) ) -RRB- cord-022053-idft1p6d 26 16 mass mass NN cord-022053-idft1p6d 26 17 spectrometry spectrometry NN cord-022053-idft1p6d 26 18 holds hold VBZ cord-022053-idft1p6d 26 19 great great JJ cord-022053-idft1p6d 26 20 promise promise NN cord-022053-idft1p6d 26 21 for for IN cord-022053-idft1p6d 26 22 all all DT cord-022053-idft1p6d 26 23 major major JJ cord-022053-idft1p6d 26 24 phyla phylum NNS cord-022053-idft1p6d 26 25 of of IN cord-022053-idft1p6d 26 26 pathogens pathogen NNS cord-022053-idft1p6d 26 27 . . . cord-022053-idft1p6d 27 1 ITS its PRP$ cord-022053-idft1p6d 27 2 _SP cord-022053-idft1p6d 27 3 ITS1 ITS1 NNP cord-022053-idft1p6d 27 4 _SP cord-022053-idft1p6d 28 1 ITS2 its2 NN cord-022053-idft1p6d 28 2 _SP cord-022053-idft1p6d 29 1 ITS5 ITS5 NNP cord-022053-idft1p6d 29 2 _SP cord-022053-idft1p6d 30 1 ITS1 ITS1 NNP cord-022053-idft1p6d 30 2 _SP cord-022053-idft1p6d 31 1 ITS2 ITS2 NNP cord-022053-idft1p6d 31 2 _SP cord-022053-idft1p6d 32 1 ITS3 ITS3 NNP cord-022053-idft1p6d 32 2 _SP cord-022053-idft1p6d 33 1 ITS4 ITS4 NNP cord-022053-idft1p6d 33 2 _SP cord-022053-idft1p6d 34 1 NL1 NL1 NNP cord-022053-idft1p6d 34 2 _SP cord-022053-idft1p6d 35 1 NL4 NL4 NNP cord-022053-idft1p6d 35 2 _SP cord-022053-idft1p6d 36 1 ITS1 ITS1 NNP cord-022053-idft1p6d 36 2 _SP cord-022053-idft1p6d 37 1 ITS2 its2 JJ cord-022053-idft1p6d 37 2 _SP cord-022053-idft1p6d 37 3 D1/ d1/ JJ cord-022053-idft1p6d 37 4 testing testing NN cord-022053-idft1p6d 37 5 . . . cord-022053-idft1p6d 38 1 Immunohistochemistry Immunohistochemistry NNP cord-022053-idft1p6d 38 2 ( ( -LRB- cord-022053-idft1p6d 38 3 IHC IHC NNP cord-022053-idft1p6d 38 4 ) ) -RRB- cord-022053-idft1p6d 38 5 in in IN cord-022053-idft1p6d 38 6 anatomic anatomic JJ cord-022053-idft1p6d 38 7 pathology pathology NN cord-022053-idft1p6d 38 8 is be VBZ cord-022053-idft1p6d 38 9 based base VBN cord-022053-idft1p6d 38 10 on on IN cord-022053-idft1p6d 38 11 the the DT cord-022053-idft1p6d 38 12 same same JJ cord-022053-idft1p6d 38 13 principle principle NN cord-022053-idft1p6d 38 14 as as IN cord-022053-idft1p6d 38 15 these these DT cord-022053-idft1p6d 38 16 rapid rapid JJ cord-022053-idft1p6d 38 17 tests test NNS cord-022053-idft1p6d 38 18 and and CC cord-022053-idft1p6d 38 19 has have VBZ cord-022053-idft1p6d 38 20 a a DT cord-022053-idft1p6d 38 21 wide wide JJ cord-022053-idft1p6d 38 22 range range NN cord-022053-idft1p6d 38 23 of of IN cord-022053-idft1p6d 38 24 uses use NNS cord-022053-idft1p6d 38 25 for for IN cord-022053-idft1p6d 38 26 the the DT cord-022053-idft1p6d 38 27 detection detection NN cord-022053-idft1p6d 38 28 and and CC cord-022053-idft1p6d 38 29 sometimes sometimes RB cord-022053-idft1p6d 38 30 speciation speciation NN cord-022053-idft1p6d 38 31 of of IN cord-022053-idft1p6d 38 32 organisms organism NNS cord-022053-idft1p6d 38 33 in in IN cord-022053-idft1p6d 38 34 formalin formalin NN cord-022053-idft1p6d 38 35 - - HYPH cord-022053-idft1p6d 38 36 fixed fix VBN cord-022053-idft1p6d 38 37 , , , cord-022053-idft1p6d 38 38 paraffin paraffin NN cord-022053-idft1p6d 38 39 - - HYPH cord-022053-idft1p6d 38 40 embedded embed VBN cord-022053-idft1p6d 38 41 tissue tissue NN cord-022053-idft1p6d 38 42 ( ( -LRB- cord-022053-idft1p6d 38 43 FFPE FFPE NNP cord-022053-idft1p6d 38 44 ) ) -RRB- cord-022053-idft1p6d 38 45 sections section NNS cord-022053-idft1p6d 38 46 . . . cord-022053-idft1p6d 39 1 Organisms organism NNS cord-022053-idft1p6d 39 2 commonly commonly RB cord-022053-idft1p6d 39 3 identified identify VBD cord-022053-idft1p6d 39 4 this this DT cord-022053-idft1p6d 39 5 way way NN cord-022053-idft1p6d 39 6 include include VBP cord-022053-idft1p6d 39 7 spirochetes spirochete NNS cord-022053-idft1p6d 39 8 , , , cord-022053-idft1p6d 39 9 mycobacteria mycobacterium NNS cord-022053-idft1p6d 39 10 , , , cord-022053-idft1p6d 39 11 DNA dna NN cord-022053-idft1p6d 39 12 viruses virus NNS cord-022053-idft1p6d 39 13 , , , cord-022053-idft1p6d 39 14 Aspergillus aspergillus NN cord-022053-idft1p6d 39 15 , , , cord-022053-idft1p6d 39 16 Candida Candida NNP cord-022053-idft1p6d 39 17 , , , cord-022053-idft1p6d 39 18 and and CC cord-022053-idft1p6d 39 19 Toxoplasma toxoplasma NN cord-022053-idft1p6d 39 20 , , , cord-022053-idft1p6d 39 21 although although IN cord-022053-idft1p6d 39 22 special special JJ cord-022053-idft1p6d 39 23 reference reference NN cord-022053-idft1p6d 39 24 laboratories laboratory NNS cord-022053-idft1p6d 39 25 ( ( -LRB- cord-022053-idft1p6d 39 26 e.g. e.g. RB cord-022053-idft1p6d 39 27 , , , cord-022053-idft1p6d 39 28 The the DT cord-022053-idft1p6d 39 29 Infectious Infectious NNP cord-022053-idft1p6d 39 30 Disease Disease NNP cord-022053-idft1p6d 39 31 Pathology Pathology NNP cord-022053-idft1p6d 39 32 Branch Branch NNP cord-022053-idft1p6d 39 33 at at IN cord-022053-idft1p6d 39 34 the the DT cord-022053-idft1p6d 39 35 Centers Centers NNPS cord-022053-idft1p6d 39 36 for for IN cord-022053-idft1p6d 39 37 Disease Disease NNP cord-022053-idft1p6d 39 38 Control Control NNP cord-022053-idft1p6d 39 39 and and CC cord-022053-idft1p6d 39 40 Prevention Prevention NNP cord-022053-idft1p6d 39 41 ) ) -RRB- cord-022053-idft1p6d 39 42 have have VBP cord-022053-idft1p6d 39 43 a a DT cord-022053-idft1p6d 39 44 wide wide JJ cord-022053-idft1p6d 39 45 range range NN cord-022053-idft1p6d 39 46 of of IN cord-022053-idft1p6d 39 47 antibodies antibody NNS cord-022053-idft1p6d 39 48 for for IN cord-022053-idft1p6d 39 49 common common JJ cord-022053-idft1p6d 39 50 to to IN cord-022053-idft1p6d 39 51 exotic exotic JJ cord-022053-idft1p6d 39 52 pathogens pathogen NNS cord-022053-idft1p6d 39 53 for for IN cord-022053-idft1p6d 39 54 tissue tissue NN cord-022053-idft1p6d 39 55 confirmation confirmation NN cord-022053-idft1p6d 39 56 . . . cord-022053-idft1p6d 40 1 MALDI MALDI NNP cord-022053-idft1p6d 40 2 - - HYPH cord-022053-idft1p6d 40 3 TOF TOF NNP cord-022053-idft1p6d 40 4 , , , cord-022053-idft1p6d 40 5 a a DT cord-022053-idft1p6d 40 6 mass mass NN cord-022053-idft1p6d 40 7 spectrometry spectrometry NN cord-022053-idft1p6d 40 8 - - HYPH cord-022053-idft1p6d 40 9 based base VBN cord-022053-idft1p6d 40 10 method method NN cord-022053-idft1p6d 40 11 , , , cord-022053-idft1p6d 40 12 allows allow VBZ cord-022053-idft1p6d 40 13 for for IN cord-022053-idft1p6d 40 14 a a DT cord-022053-idft1p6d 40 15 rapid rapid JJ cord-022053-idft1p6d 40 16 ( ( -LRB- cord-022053-idft1p6d 40 17 minutes minute NNS cord-022053-idft1p6d 40 18 ) ) -RRB- cord-022053-idft1p6d 40 19 assessment assessment NN cord-022053-idft1p6d 40 20 of of IN cord-022053-idft1p6d 40 21 the the DT cord-022053-idft1p6d 40 22 characteristic characteristic JJ cord-022053-idft1p6d 40 23 complement complement NN cord-022053-idft1p6d 40 24 of of IN cord-022053-idft1p6d 40 25 ribosomal ribosomal JJ cord-022053-idft1p6d 40 26 proteins protein NNS cord-022053-idft1p6d 40 27 in in IN cord-022053-idft1p6d 40 28 an an DT cord-022053-idft1p6d 40 29 isolate isolate NN cord-022053-idft1p6d 40 30 , , , cord-022053-idft1p6d 40 31 providing provide VBG cord-022053-idft1p6d 40 32 a a DT cord-022053-idft1p6d 40 33 species species NN cord-022053-idft1p6d 40 34 - - HYPH cord-022053-idft1p6d 40 35 level level NN cord-022053-idft1p6d 40 36 identification identification NN cord-022053-idft1p6d 40 37 in in IN cord-022053-idft1p6d 40 38 many many JJ cord-022053-idft1p6d 40 39 cases case NNS cord-022053-idft1p6d 40 40 . . . cord-022053-idft1p6d 41 1 After after IN cord-022053-idft1p6d 41 2 a a DT cord-022053-idft1p6d 41 3 microbial microbial JJ cord-022053-idft1p6d 41 4 colony colony NN cord-022053-idft1p6d 41 5 forms form NNS cord-022053-idft1p6d 41 6 , , , cord-022053-idft1p6d 41 7 it -PRON- PRP cord-022053-idft1p6d 41 8 can can MD cord-022053-idft1p6d 41 9 be be VB cord-022053-idft1p6d 41 10 spotted spot VBN cord-022053-idft1p6d 41 11 onto onto IN cord-022053-idft1p6d 41 12 a a DT cord-022053-idft1p6d 41 13 MALDI MALDI NNP cord-022053-idft1p6d 41 14 plate plate NN cord-022053-idft1p6d 41 15 in in IN cord-022053-idft1p6d 41 16 matrix matrix NN cord-022053-idft1p6d 41 17 compound compound NN cord-022053-idft1p6d 41 18 and and CC cord-022053-idft1p6d 41 19 loaded load VBN cord-022053-idft1p6d 41 20 onto onto IN cord-022053-idft1p6d 41 21 the the DT cord-022053-idft1p6d 41 22 mass mass NN cord-022053-idft1p6d 41 23 spectrophotometer spectrophotometer NN cord-022053-idft1p6d 41 24 . . . cord-022053-idft1p6d 42 1 This this DT cord-022053-idft1p6d 42 2 topic topic NN cord-022053-idft1p6d 42 3 has have VBZ cord-022053-idft1p6d 42 4 been be VBN cord-022053-idft1p6d 42 5 reviewed review VBN cord-022053-idft1p6d 42 6 in in IN cord-022053-idft1p6d 42 7 great great JJ cord-022053-idft1p6d 42 8 detail detail NN cord-022053-idft1p6d 42 9 . . . cord-022053-idft1p6d 43 1 [ [ -LRB- cord-022053-idft1p6d 43 2 3 3 CD cord-022053-idft1p6d 43 3 ] ] -RRB- cord-022053-idft1p6d 43 4 [ [ -LRB- cord-022053-idft1p6d 43 5 4 4 CD cord-022053-idft1p6d 43 6 ] ] -RRB- cord-022053-idft1p6d 43 7 [ [ -LRB- cord-022053-idft1p6d 43 8 5 5 CD cord-022053-idft1p6d 43 9 ] ] -RRB- cord-022053-idft1p6d 44 1 Briefly briefly RB cord-022053-idft1p6d 44 2 , , , cord-022053-idft1p6d 44 3 a a DT cord-022053-idft1p6d 44 4 laser laser NN cord-022053-idft1p6d 44 5 is be VBZ cord-022053-idft1p6d 44 6 focused focus VBN cord-022053-idft1p6d 44 7 onto onto IN cord-022053-idft1p6d 44 8 the the DT cord-022053-idft1p6d 44 9 sample sample NN cord-022053-idft1p6d 44 10 / / SYM cord-022053-idft1p6d 44 11 matrix matrix NN cord-022053-idft1p6d 44 12 spot spot NN cord-022053-idft1p6d 44 13 , , , cord-022053-idft1p6d 44 14 causing cause VBG cord-022053-idft1p6d 44 15 sublimation sublimation NN cord-022053-idft1p6d 44 16 , , , cord-022053-idft1p6d 44 17 ionization ionization NN cord-022053-idft1p6d 44 18 , , , cord-022053-idft1p6d 44 19 migration migration NN cord-022053-idft1p6d 44 20 through through IN cord-022053-idft1p6d 44 21 a a DT cord-022053-idft1p6d 44 22 time time NN cord-022053-idft1p6d 44 23 of of IN cord-022053-idft1p6d 44 24 flight flight NN cord-022053-idft1p6d 44 25 tube tube NN cord-022053-idft1p6d 44 26 , , , cord-022053-idft1p6d 44 27 and and CC cord-022053-idft1p6d 44 28 detection detection NN cord-022053-idft1p6d 44 29 by by IN cord-022053-idft1p6d 44 30 a a DT cord-022053-idft1p6d 44 31 mass mass NN cord-022053-idft1p6d 44 32 spectrometer spectrometer NN cord-022053-idft1p6d 44 33 ( ( -LRB- cord-022053-idft1p6d 44 34 MS).The MS).The NNP cord-022053-idft1p6d 44 35 readout readout NN cord-022053-idft1p6d 44 36 is be VBZ cord-022053-idft1p6d 44 37 a a DT cord-022053-idft1p6d 44 38 spectrum spectrum NN cord-022053-idft1p6d 44 39 of of IN cord-022053-idft1p6d 44 40 peaks peak NNS cord-022053-idft1p6d 44 41 representing represent VBG cord-022053-idft1p6d 44 42 mass mass NN cord-022053-idft1p6d 44 43 to to TO cord-022053-idft1p6d 44 44 charge charge VB cord-022053-idft1p6d 44 45 ratios ratio NNS cord-022053-idft1p6d 44 46 ( ( -LRB- cord-022053-idft1p6d 44 47 M M NNP cord-022053-idft1p6d 44 48 / / SYM cord-022053-idft1p6d 44 49 Z Z NNP cord-022053-idft1p6d 44 50 ) ) -RRB- cord-022053-idft1p6d 44 51 of of IN cord-022053-idft1p6d 44 52 different different JJ cord-022053-idft1p6d 44 53 analytes analyte NNS cord-022053-idft1p6d 44 54 . . . cord-022053-idft1p6d 45 1 The the DT cord-022053-idft1p6d 45 2 mass mass NN cord-022053-idft1p6d 45 3 range range NN cord-022053-idft1p6d 45 4 ( ( -LRB- cord-022053-idft1p6d 45 5 approximately approximately RB cord-022053-idft1p6d 45 6 2 2 CD cord-022053-idft1p6d 45 7 to to TO cord-022053-idft1p6d 45 8 20 20 CD cord-022053-idft1p6d 45 9 kDa kDa NNS cord-022053-idft1p6d 45 10 ) ) -RRB- cord-022053-idft1p6d 45 11 is be VBZ cord-022053-idft1p6d 45 12 highly highly RB cord-022053-idft1p6d 45 13 enriched enrich VBN cord-022053-idft1p6d 45 14 for for IN cord-022053-idft1p6d 45 15 ribosomal ribosomal JJ cord-022053-idft1p6d 45 16 proteins protein NNS cord-022053-idft1p6d 45 17 , , , cord-022053-idft1p6d 45 18 which which WDT cord-022053-idft1p6d 45 19 make make VBP cord-022053-idft1p6d 45 20 up up RP cord-022053-idft1p6d 45 21 a a DT cord-022053-idft1p6d 45 22 large large JJ cord-022053-idft1p6d 45 23 share share NN cord-022053-idft1p6d 45 24 of of IN cord-022053-idft1p6d 45 25 the the DT cord-022053-idft1p6d 45 26 typical typical JJ cord-022053-idft1p6d 45 27 MALDI MALDI NNP cord-022053-idft1p6d 45 28 spectra spectrum NNS cord-022053-idft1p6d 45 29 on on IN cord-022053-idft1p6d 45 30 clinical clinical JJ cord-022053-idft1p6d 45 31 instruments instrument NNS cord-022053-idft1p6d 45 32 . . . cord-022053-idft1p6d 46 1 Spectra Spectra NNP cord-022053-idft1p6d 46 2 are be VBP cord-022053-idft1p6d 46 3 compared compare VBN cord-022053-idft1p6d 46 4 with with IN cord-022053-idft1p6d 46 5 curated curate VBN cord-022053-idft1p6d 46 6 databases database NNS cord-022053-idft1p6d 46 7 and and CC cord-022053-idft1p6d 46 8 the the DT cord-022053-idft1p6d 46 9 result result NN cord-022053-idft1p6d 46 10 is be VBZ cord-022053-idft1p6d 46 11 returned return VBN cord-022053-idft1p6d 46 12 along along RP cord-022053-idft1p6d 46 13 with with IN cord-022053-idft1p6d 46 14 a a DT cord-022053-idft1p6d 46 15 metric metric JJ cord-022053-idft1p6d 46 16 describing describe VBG cord-022053-idft1p6d 46 17 the the DT cord-022053-idft1p6d 46 18 strength strength NN cord-022053-idft1p6d 46 19 of of IN cord-022053-idft1p6d 46 20 the the DT cord-022053-idft1p6d 46 21 identification identification NN cord-022053-idft1p6d 46 22 . . . cord-022053-idft1p6d 47 1 This this DT cord-022053-idft1p6d 47 2 technology technology NN cord-022053-idft1p6d 47 3 has have VBZ cord-022053-idft1p6d 47 4 been be VBN cord-022053-idft1p6d 47 5 widely widely RB cord-022053-idft1p6d 47 6 adopted adopt VBN cord-022053-idft1p6d 47 7 in in IN cord-022053-idft1p6d 47 8 Europe Europe NNP cord-022053-idft1p6d 47 9 and and CC cord-022053-idft1p6d 47 10 is be VBZ cord-022053-idft1p6d 47 11 gradually gradually RB cord-022053-idft1p6d 47 12 entering enter VBG cord-022053-idft1p6d 47 13 clinical clinical JJ cord-022053-idft1p6d 47 14 microbiology microbiology NN cord-022053-idft1p6d 47 15 labs lab NNS cord-022053-idft1p6d 47 16 in in IN cord-022053-idft1p6d 47 17 the the DT cord-022053-idft1p6d 47 18 United United NNP cord-022053-idft1p6d 47 19 States States NNP cord-022053-idft1p6d 47 20 . . . cord-022053-idft1p6d 48 1 There there EX cord-022053-idft1p6d 48 2 are be VBP cord-022053-idft1p6d 48 3 currently currently RB cord-022053-idft1p6d 48 4 two two CD cord-022053-idft1p6d 48 5 US US NNP cord-022053-idft1p6d 48 6 Food Food NNP cord-022053-idft1p6d 48 7 and and CC cord-022053-idft1p6d 48 8 Drug Drug NNP cord-022053-idft1p6d 48 9 Administration Administration NNP cord-022053-idft1p6d 48 10 ( ( -LRB- cord-022053-idft1p6d 48 11 FDA)-approved FDA)-approved NNP cord-022053-idft1p6d 48 12 systems system NNS cord-022053-idft1p6d 48 13 : : : cord-022053-idft1p6d 48 14 the the DT cord-022053-idft1p6d 48 15 Vitek Vitek NNP cord-022053-idft1p6d 48 16 MS MS NNP cord-022053-idft1p6d 48 17 ( ( -LRB- cord-022053-idft1p6d 48 18 BioMérieux BioMérieux NNP cord-022053-idft1p6d 48 19 , , , cord-022053-idft1p6d 48 20 Durham Durham NNP cord-022053-idft1p6d 48 21 , , , cord-022053-idft1p6d 48 22 North North NNP cord-022053-idft1p6d 48 23 Carolina Carolina NNP cord-022053-idft1p6d 48 24 ) ) -RRB- cord-022053-idft1p6d 48 25 and and CC cord-022053-idft1p6d 48 26 the the DT cord-022053-idft1p6d 48 27 MALDI MALDI NNP cord-022053-idft1p6d 48 28 Biotyper Biotyper NNP cord-022053-idft1p6d 48 29 ( ( -LRB- cord-022053-idft1p6d 48 30 Bruker Bruker NNP cord-022053-idft1p6d 48 31 Daltonics Daltonics NNP cord-022053-idft1p6d 48 32 Inc. Inc. NNP cord-022053-idft1p6d 48 33 , , , cord-022053-idft1p6d 48 34 Billerica Billerica NNP cord-022053-idft1p6d 48 35 , , , cord-022053-idft1p6d 48 36 Massachusetts Massachusetts NNP cord-022053-idft1p6d 48 37 ) ) -RRB- cord-022053-idft1p6d 48 38 . . . cord-022053-idft1p6d 49 1 Although although IN cord-022053-idft1p6d 49 2 the the DT cord-022053-idft1p6d 49 3 technology technology NN cord-022053-idft1p6d 49 4 behind behind IN cord-022053-idft1p6d 49 5 these these DT cord-022053-idft1p6d 49 6 two two CD cord-022053-idft1p6d 49 7 systems system NNS cord-022053-idft1p6d 49 8 is be VBZ cord-022053-idft1p6d 49 9 essentially essentially RB cord-022053-idft1p6d 49 10 equivalent equivalent JJ cord-022053-idft1p6d 49 11 , , , cord-022053-idft1p6d 49 12 they -PRON- PRP cord-022053-idft1p6d 49 13 differ differ VBP cord-022053-idft1p6d 49 14 in in IN cord-022053-idft1p6d 49 15 their -PRON- PRP$ cord-022053-idft1p6d 49 16 curated curate VBN cord-022053-idft1p6d 49 17 libraries library NNS cord-022053-idft1p6d 49 18 , , , cord-022053-idft1p6d 49 19 software software NN cord-022053-idft1p6d 49 20 , , , cord-022053-idft1p6d 49 21 identification identification NN cord-022053-idft1p6d 49 22 algorithms algorithm NNS cord-022053-idft1p6d 49 23 , , , cord-022053-idft1p6d 49 24 and and CC cord-022053-idft1p6d 49 25 scoring score VBG cord-022053-idft1p6d 49 26 systems system NNS cord-022053-idft1p6d 49 27 . . . cord-022053-idft1p6d 50 1 5 5 LS cord-022053-idft1p6d 51 1 For for IN cord-022053-idft1p6d 51 2 example example NN cord-022053-idft1p6d 51 3 , , , cord-022053-idft1p6d 51 4 the the DT cord-022053-idft1p6d 51 5 Vitek Vitek NNP cord-022053-idft1p6d 51 6 MS MS NNP cord-022053-idft1p6d 51 7 reports report VBZ cord-022053-idft1p6d 51 8 isolates isolate NNS cord-022053-idft1p6d 51 9 with with IN cord-022053-idft1p6d 51 10 a a DT cord-022053-idft1p6d 51 11 confidence confidence NN cord-022053-idft1p6d 51 12 value value NN cord-022053-idft1p6d 51 13 of of IN cord-022053-idft1p6d 51 14 1 1 CD cord-022053-idft1p6d 51 15 % % NN cord-022053-idft1p6d 51 16 to to TO cord-022053-idft1p6d 51 17 100 100 CD cord-022053-idft1p6d 51 18 % % NN cord-022053-idft1p6d 51 19 , , , cord-022053-idft1p6d 51 20 whereas whereas IN cord-022053-idft1p6d 51 21 the the DT cord-022053-idft1p6d 51 22 Biotyper Biotyper NNP cord-022053-idft1p6d 51 23 returns return VBZ cord-022053-idft1p6d 51 24 a a DT cord-022053-idft1p6d 51 25 score score NN cord-022053-idft1p6d 51 26 that that WDT cord-022053-idft1p6d 51 27 can can MD cord-022053-idft1p6d 51 28 range range VB cord-022053-idft1p6d 51 29 from from IN cord-022053-idft1p6d 51 30 0 0 CD cord-022053-idft1p6d 51 31 to to IN cord-022053-idft1p6d 51 32 3.000 3.000 CD cord-022053-idft1p6d 51 33 . . . cord-022053-idft1p6d 52 1 For for IN cord-022053-idft1p6d 52 2 most most JJS cord-022053-idft1p6d 52 3 applications application NNS cord-022053-idft1p6d 52 4 a a DT cord-022053-idft1p6d 52 5 score score NN cord-022053-idft1p6d 52 6 of of IN cord-022053-idft1p6d 52 7 2.000 2.000 CD cord-022053-idft1p6d 52 8 or or CC cord-022053-idft1p6d 52 9 greater great JJR cord-022053-idft1p6d 52 10 is be VBZ cord-022053-idft1p6d 52 11 necessary necessary JJ cord-022053-idft1p6d 52 12 for for IN cord-022053-idft1p6d 52 13 a a DT cord-022053-idft1p6d 52 14 species species NN cord-022053-idft1p6d 52 15 level level NN cord-022053-idft1p6d 52 16 identification identification NN cord-022053-idft1p6d 52 17 . . . cord-022053-idft1p6d 53 1 Because because IN cord-022053-idft1p6d 53 2 of of IN cord-022053-idft1p6d 53 3 this this DT cord-022053-idft1p6d 53 4 , , , cord-022053-idft1p6d 53 5 it -PRON- PRP cord-022053-idft1p6d 53 6 can can MD cord-022053-idft1p6d 53 7 be be VB cord-022053-idft1p6d 53 8 difficult difficult JJ cord-022053-idft1p6d 53 9 to to TO cord-022053-idft1p6d 53 10 directly directly RB cord-022053-idft1p6d 53 11 compare compare VB cord-022053-idft1p6d 53 12 results result NNS cord-022053-idft1p6d 53 13 between between IN cord-022053-idft1p6d 53 14 the the DT cord-022053-idft1p6d 53 15 two two CD cord-022053-idft1p6d 53 16 systems system NNS cord-022053-idft1p6d 53 17 . . . cord-022053-idft1p6d 54 1 There there EX cord-022053-idft1p6d 54 2 have have VBP cord-022053-idft1p6d 54 3 been be VBN cord-022053-idft1p6d 54 4 several several JJ cord-022053-idft1p6d 54 5 studies study NNS cord-022053-idft1p6d 54 6 using use VBG cord-022053-idft1p6d 54 7 both both DT cord-022053-idft1p6d 54 8 platforms platform NNS cord-022053-idft1p6d 54 9 back back RB cord-022053-idft1p6d 54 10 to to IN cord-022053-idft1p6d 54 11 back back NN cord-022053-idft1p6d 54 12 . . . cord-022053-idft1p6d 55 1 One one CD cord-022053-idft1p6d 55 2 study study NN cord-022053-idft1p6d 55 3 on on IN cord-022053-idft1p6d 55 4 a a DT cord-022053-idft1p6d 55 5 large large JJ cord-022053-idft1p6d 55 6 collection collection NN cord-022053-idft1p6d 55 7 of of IN cord-022053-idft1p6d 55 8 642 642 CD cord-022053-idft1p6d 55 9 strains strain NNS cord-022053-idft1p6d 55 10 of of IN cord-022053-idft1p6d 55 11 bacteria bacteria NNS cord-022053-idft1p6d 55 12 , , , cord-022053-idft1p6d 55 13 yeasts yeast NNS cord-022053-idft1p6d 55 14 , , , cord-022053-idft1p6d 55 15 and and CC cord-022053-idft1p6d 55 16 molds mold NNS cord-022053-idft1p6d 55 17 demonstrated demonstrate VBD cord-022053-idft1p6d 55 18 comparable comparable JJ cord-022053-idft1p6d 55 19 performance performance NN cord-022053-idft1p6d 55 20 , , , cord-022053-idft1p6d 55 21 although although IN cord-022053-idft1p6d 55 22 noting note VBG cord-022053-idft1p6d 55 23 that that IN cord-022053-idft1p6d 55 24 the the DT cord-022053-idft1p6d 55 25 library library NN cord-022053-idft1p6d 55 26 coverage coverage NN cord-022053-idft1p6d 55 27 of of IN cord-022053-idft1p6d 55 28 the the DT cord-022053-idft1p6d 55 29 test test NN cord-022053-idft1p6d 55 30 cohort cohort NN cord-022053-idft1p6d 55 31 was be VBD cord-022053-idft1p6d 55 32 greater great JJR cord-022053-idft1p6d 55 33 with with IN cord-022053-idft1p6d 55 34 the the DT cord-022053-idft1p6d 55 35 Biotyper Biotyper NNP cord-022053-idft1p6d 55 36 ( ( -LRB- cord-022053-idft1p6d 55 37 572 572 CD cord-022053-idft1p6d 55 38 strains strain NNS cord-022053-idft1p6d 55 39 ) ) -RRB- cord-022053-idft1p6d 55 40 than than IN cord-022053-idft1p6d 55 41 the the DT cord-022053-idft1p6d 55 42 Vitek Vitek NNP cord-022053-idft1p6d 55 43 MS MS NNP cord-022053-idft1p6d 55 44 ( ( -LRB- cord-022053-idft1p6d 55 45 406 406 CD cord-022053-idft1p6d 55 46 ) ) -RRB- cord-022053-idft1p6d 55 47 and and CC cord-022053-idft1p6d 55 48 that that IN cord-022053-idft1p6d 55 49 the the DT cord-022053-idft1p6d 55 50 Vitek Vitek NNP cord-022053-idft1p6d 55 51 was be VBD cord-022053-idft1p6d 55 52 more more RBR cord-022053-idft1p6d 55 53 likely likely JJ cord-022053-idft1p6d 55 54 to to TO cord-022053-idft1p6d 55 55 output output VB cord-022053-idft1p6d 55 56 a a DT cord-022053-idft1p6d 55 57 misidentification misidentification NN cord-022053-idft1p6d 55 58 for for IN cord-022053-idft1p6d 55 59 strains strain NNS cord-022053-idft1p6d 55 60 not not RB cord-022053-idft1p6d 55 61 represented represent VBN cord-022053-idft1p6d 55 62 in in IN cord-022053-idft1p6d 55 63 the the DT cord-022053-idft1p6d 55 64 library library NN cord-022053-idft1p6d 55 65 . . . cord-022053-idft1p6d 56 1 6 6 CD cord-022053-idft1p6d 57 1 For for IN cord-022053-idft1p6d 57 2 FDA FDA NNP cord-022053-idft1p6d 57 3 - - HYPH cord-022053-idft1p6d 57 4 approved approve VBN cord-022053-idft1p6d 57 5 applications application NNS cord-022053-idft1p6d 57 6 , , , cord-022053-idft1p6d 57 7 both both CC cord-022053-idft1p6d 57 8 the the DT cord-022053-idft1p6d 57 9 Vitek Vitek NNP cord-022053-idft1p6d 57 10 MS MS NNP cord-022053-idft1p6d 57 11 and and CC cord-022053-idft1p6d 57 12 the the DT cord-022053-idft1p6d 57 13 Bruker Bruker NNP cord-022053-idft1p6d 57 14 may may MD cord-022053-idft1p6d 57 15 be be VB cord-022053-idft1p6d 57 16 used use VBN cord-022053-idft1p6d 57 17 for for IN cord-022053-idft1p6d 57 18 a a DT cord-022053-idft1p6d 57 19 large large JJ cord-022053-idft1p6d 57 20 library library NN cord-022053-idft1p6d 57 21 of of IN cord-022053-idft1p6d 57 22 aerobic aerobic JJ cord-022053-idft1p6d 57 23 gram gram NN cord-022053-idft1p6d 57 24 - - HYPH cord-022053-idft1p6d 57 25 negative negative JJ cord-022053-idft1p6d 57 26 and and CC cord-022053-idft1p6d 57 27 gram gram NN cord-022053-idft1p6d 57 28 - - HYPH cord-022053-idft1p6d 57 29 positive positive JJ cord-022053-idft1p6d 57 30 organisms organism NNS cord-022053-idft1p6d 57 31 , , , cord-022053-idft1p6d 57 32 as as RB cord-022053-idft1p6d 57 33 well well RB cord-022053-idft1p6d 57 34 as as IN cord-022053-idft1p6d 57 35 several several JJ cord-022053-idft1p6d 57 36 anaerobes anaerobe NNS cord-022053-idft1p6d 57 37 and and CC cord-022053-idft1p6d 57 38 yeast yeast NN cord-022053-idft1p6d 57 39 . . . cord-022053-idft1p6d 58 1 In in IN cord-022053-idft1p6d 58 2 general general JJ cord-022053-idft1p6d 58 3 , , , cord-022053-idft1p6d 58 4 performance performance NN cord-022053-idft1p6d 58 5 has have VBZ cord-022053-idft1p6d 58 6 been be VBN cord-022053-idft1p6d 58 7 reported report VBN cord-022053-idft1p6d 58 8 to to TO cord-022053-idft1p6d 58 9 equal equal VB cord-022053-idft1p6d 58 10 or or CC cord-022053-idft1p6d 58 11 exceed exceed VB cord-022053-idft1p6d 58 12 traditional traditional JJ cord-022053-idft1p6d 58 13 biochemical biochemical JJ cord-022053-idft1p6d 58 14 systems system NNS cord-022053-idft1p6d 58 15 , , , cord-022053-idft1p6d 58 16 although although IN cord-022053-idft1p6d 58 17 it -PRON- PRP cord-022053-idft1p6d 58 18 seems seem VBZ cord-022053-idft1p6d 58 19 to to TO cord-022053-idft1p6d 58 20 be be VB cord-022053-idft1p6d 58 21 stronger strong JJR cord-022053-idft1p6d 58 22 for for IN cord-022053-idft1p6d 58 23 gram gram NN cord-022053-idft1p6d 58 24 - - HYPH cord-022053-idft1p6d 58 25 negative negative JJ cord-022053-idft1p6d 58 26 than than IN cord-022053-idft1p6d 58 27 gram gram NN cord-022053-idft1p6d 58 28 - - HYPH cord-022053-idft1p6d 58 29 positive positive JJ cord-022053-idft1p6d 58 30 organisms organism NNS cord-022053-idft1p6d 58 31 . . . cord-022053-idft1p6d 59 1 5 5 LS cord-022053-idft1p6d 59 2 , , , cord-022053-idft1p6d 59 3 7 7 CD cord-022053-idft1p6d 59 4 Lackluster lackluster JJ cord-022053-idft1p6d 59 5 performance performance NN cord-022053-idft1p6d 59 6 , , , cord-022053-idft1p6d 59 7 in in IN cord-022053-idft1p6d 59 8 particular particular JJ cord-022053-idft1p6d 59 9 , , , cord-022053-idft1p6d 59 10 has have VBZ cord-022053-idft1p6d 59 11 been be VBN cord-022053-idft1p6d 59 12 noted note VBN cord-022053-idft1p6d 59 13 for for IN cord-022053-idft1p6d 59 14 several several JJ cord-022053-idft1p6d 59 15 grampositive grampositive JJ cord-022053-idft1p6d 59 16 rods rod NNS cord-022053-idft1p6d 59 17 . . . cord-022053-idft1p6d 60 1 In in IN cord-022053-idft1p6d 60 2 a a DT cord-022053-idft1p6d 60 3 study study NN cord-022053-idft1p6d 60 4 with with IN cord-022053-idft1p6d 60 5 the the DT cord-022053-idft1p6d 60 6 Biotyper Biotyper NNP cord-022053-idft1p6d 60 7 , , , cord-022053-idft1p6d 60 8 the the DT cord-022053-idft1p6d 60 9 system system NN cord-022053-idft1p6d 60 10 was be VBD cord-022053-idft1p6d 60 11 unable unable JJ cord-022053-idft1p6d 60 12 to to TO cord-022053-idft1p6d 60 13 identify identify VB cord-022053-idft1p6d 60 14 several several JJ cord-022053-idft1p6d 60 15 isolates isolate NNS cord-022053-idft1p6d 60 16 of of IN cord-022053-idft1p6d 60 17 Nocardia Nocardia NNP cord-022053-idft1p6d 60 18 , , , cord-022053-idft1p6d 60 19 Tsukamurella Tsukamurella NNP cord-022053-idft1p6d 60 20 , , , cord-022053-idft1p6d 60 21 Kocuria Kocuria NNP cord-022053-idft1p6d 60 22 , , , cord-022053-idft1p6d 60 23 or or CC cord-022053-idft1p6d 60 24 Gordonia Gordonia NNP cord-022053-idft1p6d 60 25 , , , cord-022053-idft1p6d 60 26 although although IN cord-022053-idft1p6d 60 27 89.7 89.7 CD cord-022053-idft1p6d 60 28 % % NN cord-022053-idft1p6d 60 29 of of IN cord-022053-idft1p6d 60 30 Listeria Listeria NNP cord-022053-idft1p6d 60 31 and and CC cord-022053-idft1p6d 60 32 80 80 CD cord-022053-idft1p6d 60 33 % % NN cord-022053-idft1p6d 60 34 of of IN cord-022053-idft1p6d 60 35 Rhodococcus Rhodococcus NNP cord-022053-idft1p6d 60 36 were be VBD cord-022053-idft1p6d 60 37 correctly correctly RB cord-022053-idft1p6d 60 38 classified classify VBN cord-022053-idft1p6d 60 39 . . . cord-022053-idft1p6d 61 1 8 8 CD cord-022053-idft1p6d 61 2 Members member NNS cord-022053-idft1p6d 61 3 of of IN cord-022053-idft1p6d 61 4 Corynebacteria Corynebacteria NNP cord-022053-idft1p6d 61 5 , , , cord-022053-idft1p6d 61 6 Lactobacillus Lactobacillus NNP cord-022053-idft1p6d 61 7 , , , cord-022053-idft1p6d 61 8 and and CC cord-022053-idft1p6d 61 9 some some DT cord-022053-idft1p6d 61 10 Listeria Listeria NNP cord-022053-idft1p6d 61 11 also also RB cord-022053-idft1p6d 61 12 seem seem VBP cord-022053-idft1p6d 61 13 to to TO cord-022053-idft1p6d 61 14 present present VB cord-022053-idft1p6d 61 15 some some DT cord-022053-idft1p6d 61 16 difficulty difficulty NN cord-022053-idft1p6d 61 17 , , , cord-022053-idft1p6d 61 18 both both CC cord-022053-idft1p6d 61 19 in in IN cord-022053-idft1p6d 61 20 terms term NNS cord-022053-idft1p6d 61 21 of of IN cord-022053-idft1p6d 61 22 difficulty difficulty NN cord-022053-idft1p6d 61 23 discriminating discriminate VBG cord-022053-idft1p6d 61 24 between between IN cord-022053-idft1p6d 61 25 species specie NNS cord-022053-idft1p6d 61 26 and and CC cord-022053-idft1p6d 61 27 in in IN cord-022053-idft1p6d 61 28 requiring require VBG cord-022053-idft1p6d 61 29 a a DT cord-022053-idft1p6d 61 30 lowered lower VBN cord-022053-idft1p6d 61 31 score score NN cord-022053-idft1p6d 61 32 cutoff cutoff NN cord-022053-idft1p6d 61 33 ( ( -LRB- cord-022053-idft1p6d 61 34 1.7 1.7 CD cord-022053-idft1p6d 61 35 ) ) -RRB- cord-022053-idft1p6d 61 36 for for IN cord-022053-idft1p6d 61 37 species species NN cord-022053-idft1p6d 61 38 - - HYPH cord-022053-idft1p6d 61 39 level level NN cord-022053-idft1p6d 61 40 identification identification NN cord-022053-idft1p6d 61 41 . . . cord-022053-idft1p6d 62 1 9 9 CD cord-022053-idft1p6d 63 1 In in IN cord-022053-idft1p6d 63 2 similar similar JJ cord-022053-idft1p6d 63 3 studies study NNS cord-022053-idft1p6d 63 4 using use VBG cord-022053-idft1p6d 63 5 the the DT cord-022053-idft1p6d 63 6 Vitek Vitek NNP cord-022053-idft1p6d 63 7 platform platform NN cord-022053-idft1p6d 63 8 , , , cord-022053-idft1p6d 63 9 there there EX cord-022053-idft1p6d 63 10 were be VBD cord-022053-idft1p6d 63 11 also also RB cord-022053-idft1p6d 63 12 reported report VBN cord-022053-idft1p6d 63 13 problems problem NNS cord-022053-idft1p6d 63 14 in in IN cord-022053-idft1p6d 63 15 speciation speciation NN cord-022053-idft1p6d 63 16 of of IN cord-022053-idft1p6d 63 17 Listeria Listeria NNP cord-022053-idft1p6d 63 18 . . . cord-022053-idft1p6d 64 1 10 10 CD cord-022053-idft1p6d 65 1 The the DT cord-022053-idft1p6d 65 2 misidentification misidentification NN cord-022053-idft1p6d 65 3 of of IN cord-022053-idft1p6d 65 4 a a DT cord-022053-idft1p6d 65 5 Kocuria Kocuria NNP cord-022053-idft1p6d 65 6 as as IN cord-022053-idft1p6d 65 7 a a DT cord-022053-idft1p6d 65 8 Corynebacterium Corynebacterium NNP cord-022053-idft1p6d 65 9 has have VBZ cord-022053-idft1p6d 65 10 also also RB cord-022053-idft1p6d 65 11 been be VBN cord-022053-idft1p6d 65 12 reported report VBN cord-022053-idft1p6d 65 13 . . . cord-022053-idft1p6d 66 1 11 11 CD cord-022053-idft1p6d 67 1 Among among IN cord-022053-idft1p6d 67 2 both both DT cord-022053-idft1p6d 67 3 gram gram NN cord-022053-idft1p6d 67 4 - - HYPH cord-022053-idft1p6d 67 5 positive positive JJ cord-022053-idft1p6d 67 6 and and CC cord-022053-idft1p6d 67 7 gram gram JJ cord-022053-idft1p6d 67 8 - - HYPH cord-022053-idft1p6d 67 9 negative negative JJ cord-022053-idft1p6d 67 10 organisms organism NNS cord-022053-idft1p6d 67 11 , , , cord-022053-idft1p6d 67 12 MALDI MALDI NNP cord-022053-idft1p6d 67 13 - - HYPH cord-022053-idft1p6d 67 14 TOF TOF NNP cord-022053-idft1p6d 67 15 has have VBZ cord-022053-idft1p6d 67 16 several several JJ cord-022053-idft1p6d 67 17 well well RB cord-022053-idft1p6d 67 18 - - HYPH cord-022053-idft1p6d 67 19 characterized characterize VBN cord-022053-idft1p6d 67 20 difficulties difficulty NNS cord-022053-idft1p6d 67 21 discriminating discriminate VBG cord-022053-idft1p6d 67 22 certain certain JJ cord-022053-idft1p6d 67 23 species specie NNS cord-022053-idft1p6d 67 24 and and CC cord-022053-idft1p6d 67 25 complexes complex NNS cord-022053-idft1p6d 67 26 , , , cord-022053-idft1p6d 67 27 including include VBG cord-022053-idft1p6d 67 28 Streptococcus streptococcus NN cord-022053-idft1p6d 67 29 pneumoniae/ pneumoniae/ NN cord-022053-idft1p6d 67 30 Streptococcus Streptococcus NNP cord-022053-idft1p6d 67 31 mitis mitis NN cord-022053-idft1p6d 67 32 , , , cord-022053-idft1p6d 67 33 Escherichia Escherichia NNP cord-022053-idft1p6d 67 34 coli coli NNS cord-022053-idft1p6d 67 35 / / SYM cord-022053-idft1p6d 67 36 Shigella Shigella NNP cord-022053-idft1p6d 67 37 , , , cord-022053-idft1p6d 67 38 and and CC cord-022053-idft1p6d 67 39 members member NNS cord-022053-idft1p6d 67 40 of of IN cord-022053-idft1p6d 67 41 the the DT cord-022053-idft1p6d 67 42 Enterobacter Enterobacter NNP cord-022053-idft1p6d 67 43 cloacae cloacae NN cord-022053-idft1p6d 67 44 complex complex NN cord-022053-idft1p6d 67 45 . . . cord-022053-idft1p6d 68 1 3 3 CD cord-022053-idft1p6d 68 2 Finally finally RB cord-022053-idft1p6d 68 3 , , , cord-022053-idft1p6d 68 4 it -PRON- PRP cord-022053-idft1p6d 68 5 is be VBZ cord-022053-idft1p6d 68 6 important important JJ cord-022053-idft1p6d 68 7 to to TO cord-022053-idft1p6d 68 8 note note VB cord-022053-idft1p6d 68 9 that that IN cord-022053-idft1p6d 68 10 the the DT cord-022053-idft1p6d 68 11 Biotyper Biotyper NNP cord-022053-idft1p6d 68 12 requires require VBZ cord-022053-idft1p6d 68 13 a a DT cord-022053-idft1p6d 68 14 Security Security NNP cord-022053-idft1p6d 68 15 - - HYPH cord-022053-idft1p6d 68 16 Relevant Relevant NNP cord-022053-idft1p6d 68 17 Library Library NNP cord-022053-idft1p6d 68 18 for for IN cord-022053-idft1p6d 68 19 the the DT cord-022053-idft1p6d 68 20 identification identification NN cord-022053-idft1p6d 68 21 of of IN cord-022053-idft1p6d 68 22 such such JJ cord-022053-idft1p6d 68 23 organisms organism NNS cord-022053-idft1p6d 68 24 as as IN cord-022053-idft1p6d 68 25 Francisella Francisella NNP cord-022053-idft1p6d 68 26 tularensis tularensis NNP cord-022053-idft1p6d 68 27 , , , cord-022053-idft1p6d 68 28 Burkholderia Burkholderia NNP cord-022053-idft1p6d 68 29 pseudomallei pseudomallei NN cord-022053-idft1p6d 68 30 , , , cord-022053-idft1p6d 68 31 and and CC cord-022053-idft1p6d 68 32 Brucella Brucella NNP cord-022053-idft1p6d 68 33 spp spp NNS cord-022053-idft1p6d 68 34 . . . cord-022053-idft1p6d 69 1 12 12 CD cord-022053-idft1p6d 69 2 MALDI MALDI NNS cord-022053-idft1p6d 69 3 is be VBZ cord-022053-idft1p6d 69 4 rapidly rapidly RB cord-022053-idft1p6d 69 5 becoming become VBG cord-022053-idft1p6d 69 6 the the DT cord-022053-idft1p6d 69 7 method method NN cord-022053-idft1p6d 69 8 of of IN cord-022053-idft1p6d 69 9 choice choice NN cord-022053-idft1p6d 69 10 for for IN cord-022053-idft1p6d 69 11 identifying identify VBG cord-022053-idft1p6d 69 12 anaerobic anaerobic JJ cord-022053-idft1p6d 69 13 bacteria bacteria NNS cord-022053-idft1p6d 69 14 . . . cord-022053-idft1p6d 70 1 13 13 CD cord-022053-idft1p6d 71 1 Several several JJ cord-022053-idft1p6d 71 2 studies study NNS cord-022053-idft1p6d 71 3 using use VBG cord-022053-idft1p6d 71 4 large large JJ cord-022053-idft1p6d 71 5 , , , cord-022053-idft1p6d 71 6 diverse diverse JJ cord-022053-idft1p6d 71 7 collections collection NNS cord-022053-idft1p6d 71 8 of of IN cord-022053-idft1p6d 71 9 anaerobes anaerobe NNS cord-022053-idft1p6d 71 10 have have VBP cord-022053-idft1p6d 71 11 demonstrated demonstrate VBN cord-022053-idft1p6d 71 12 strong strong JJ cord-022053-idft1p6d 71 13 performances performance NNS cord-022053-idft1p6d 71 14 by by IN cord-022053-idft1p6d 71 15 both both CC cord-022053-idft1p6d 71 16 the the DT cord-022053-idft1p6d 71 17 BioTyper BioTyper NNP cord-022053-idft1p6d 71 18 and and CC cord-022053-idft1p6d 71 19 the the DT cord-022053-idft1p6d 71 20 Vitek Vitek NNP cord-022053-idft1p6d 71 21 MS MS NNP cord-022053-idft1p6d 71 22 . . . cord-022053-idft1p6d 72 1 5 5 LS cord-022053-idft1p6d 73 1 In in IN cord-022053-idft1p6d 73 2 one one CD cord-022053-idft1p6d 73 3 recent recent JJ cord-022053-idft1p6d 73 4 multicenter multicenter JJ cord-022053-idft1p6d 73 5 trial trial NN cord-022053-idft1p6d 73 6 bringing bring VBG cord-022053-idft1p6d 73 7 together together RB cord-022053-idft1p6d 73 8 651 651 CD cord-022053-idft1p6d 73 9 anaerobic anaerobic JJ cord-022053-idft1p6d 73 10 isolates isolate NNS cord-022053-idft1p6d 73 11 for for IN cord-022053-idft1p6d 73 12 analysis analysis NN cord-022053-idft1p6d 73 13 by by IN cord-022053-idft1p6d 73 14 the the DT cord-022053-idft1p6d 73 15 Vitek Vitek NNP cord-022053-idft1p6d 73 16 MS MS NNP cord-022053-idft1p6d 73 17 2.0 2.0 CD cord-022053-idft1p6d 73 18 , , , cord-022053-idft1p6d 73 19 91.2 91.2 CD cord-022053-idft1p6d 73 20 % % NN cord-022053-idft1p6d 73 21 of of IN cord-022053-idft1p6d 73 22 the the DT cord-022053-idft1p6d 73 23 isolates isolate NNS cord-022053-idft1p6d 73 24 were be VBD cord-022053-idft1p6d 73 25 correctly correctly RB cord-022053-idft1p6d 73 26 identified identify VBN cord-022053-idft1p6d 73 27 to to IN cord-022053-idft1p6d 73 28 species species NN cord-022053-idft1p6d 73 29 level level NN cord-022053-idft1p6d 73 30 . . . cord-022053-idft1p6d 74 1 14 14 CD cord-022053-idft1p6d 75 1 The the DT cord-022053-idft1p6d 75 2 most most RBS cord-022053-idft1p6d 75 3 notable notable JJ cord-022053-idft1p6d 75 4 difficulty difficulty NN cord-022053-idft1p6d 75 5 was be VBD cord-022053-idft1p6d 75 6 in in IN cord-022053-idft1p6d 75 7 identifying identify VBG cord-022053-idft1p6d 75 8 Fusobacterium Fusobacterium NNP cord-022053-idft1p6d 75 9 nucleatum nucleatum NN cord-022053-idft1p6d 75 10 ( ( -LRB- cord-022053-idft1p6d 75 11 42.9 42.9 CD cord-022053-idft1p6d 75 12 % % NN cord-022053-idft1p6d 75 13 identified identify VBN cord-022053-idft1p6d 75 14 correctly correctly RB cord-022053-idft1p6d 75 15 ) ) -RRB- cord-022053-idft1p6d 75 16 . . . cord-022053-idft1p6d 76 1 The the DT cord-022053-idft1p6d 76 2 system system NN cord-022053-idft1p6d 76 3 also also RB cord-022053-idft1p6d 76 4 showed show VBD cord-022053-idft1p6d 76 5 lower low JJR cord-022053-idft1p6d 76 6 performance performance NN cord-022053-idft1p6d 76 7 for for IN cord-022053-idft1p6d 76 8 certain certain JJ cord-022053-idft1p6d 76 9 species specie NNS cord-022053-idft1p6d 76 10 of of IN cord-022053-idft1p6d 76 11 Bacteroides Bacteroides NNP cord-022053-idft1p6d 76 12 , , , cord-022053-idft1p6d 76 13 Actinomyces Actinomyces NNP cord-022053-idft1p6d 76 14 , , , cord-022053-idft1p6d 76 15 and and CC cord-022053-idft1p6d 76 16 Prevotella Prevotella NNP cord-022053-idft1p6d 76 17 . . . cord-022053-idft1p6d 77 1 Similarly similarly RB cord-022053-idft1p6d 77 2 , , , cord-022053-idft1p6d 77 3 in in IN cord-022053-idft1p6d 77 4 a a DT cord-022053-idft1p6d 77 5 study study NN cord-022053-idft1p6d 77 6 using use VBG cord-022053-idft1p6d 77 7 the the DT cord-022053-idft1p6d 77 8 Biotyper Biotyper NNP cord-022053-idft1p6d 77 9 platform platform NN cord-022053-idft1p6d 77 10 to to TO cord-022053-idft1p6d 77 11 identify identify VB cord-022053-idft1p6d 77 12 197 197 CD cord-022053-idft1p6d 77 13 anaerobes anaerobe NNS cord-022053-idft1p6d 77 14 isolated isolate VBN cord-022053-idft1p6d 77 15 from from IN cord-022053-idft1p6d 77 16 blood blood NN cord-022053-idft1p6d 77 17 cultures culture NNS cord-022053-idft1p6d 77 18 , , , cord-022053-idft1p6d 77 19 86.8 86.8 CD cord-022053-idft1p6d 77 20 % % NN cord-022053-idft1p6d 77 21 of of IN cord-022053-idft1p6d 77 22 the the DT cord-022053-idft1p6d 77 23 strains strain NNS cord-022053-idft1p6d 77 24 were be VBD cord-022053-idft1p6d 77 25 correctly correctly RB cord-022053-idft1p6d 77 26 identified identify VBN cord-022053-idft1p6d 77 27 to to IN cord-022053-idft1p6d 77 28 the the DT cord-022053-idft1p6d 77 29 species species NN cord-022053-idft1p6d 77 30 level level NN cord-022053-idft1p6d 77 31 ( ( -LRB- cord-022053-idft1p6d 77 32 using use VBG cord-022053-idft1p6d 77 33 a a DT cord-022053-idft1p6d 77 34 score score NN cord-022053-idft1p6d 77 35 of of IN cord-022053-idft1p6d 77 36 2 2 CD cord-022053-idft1p6d 77 37 ) ) -RRB- cord-022053-idft1p6d 77 38 and and CC cord-022053-idft1p6d 77 39 94.9 94.9 CD cord-022053-idft1p6d 77 40 % % NN cord-022053-idft1p6d 77 41 to to IN cord-022053-idft1p6d 77 42 the the DT cord-022053-idft1p6d 77 43 genus genus NN cord-022053-idft1p6d 77 44 level level NN cord-022053-idft1p6d 77 45 . . . cord-022053-idft1p6d 78 1 15 15 CD cord-022053-idft1p6d 79 1 Fusobacterium Fusobacterium NNP cord-022053-idft1p6d 79 2 spp spp NNS cord-022053-idft1p6d 79 3 . . . cord-022053-idft1p6d 80 1 was be VBD cord-022053-idft1p6d 80 2 again again RB cord-022053-idft1p6d 80 3 problematic problematic JJ cord-022053-idft1p6d 80 4 , , , cord-022053-idft1p6d 80 5 with with IN cord-022053-idft1p6d 80 6 only only RB cord-022053-idft1p6d 80 7 23 23 CD cord-022053-idft1p6d 80 8 % % NN cord-022053-idft1p6d 80 9 being be VBG cord-022053-idft1p6d 80 10 correctly correctly RB cord-022053-idft1p6d 80 11 identified identify VBN cord-022053-idft1p6d 80 12 to to IN cord-022053-idft1p6d 80 13 the the DT cord-022053-idft1p6d 80 14 species species NN cord-022053-idft1p6d 80 15 level level NN cord-022053-idft1p6d 80 16 . . . cord-022053-idft1p6d 81 1 With with IN cord-022053-idft1p6d 81 2 formic formic JJ cord-022053-idft1p6d 81 3 acid acid NN cord-022053-idft1p6d 81 4 / / SYM cord-022053-idft1p6d 81 5 ethanol ethanol NN cord-022053-idft1p6d 81 6 pretreatment pretreatment NN cord-022053-idft1p6d 81 7 , , , cord-022053-idft1p6d 81 8 this this DT cord-022053-idft1p6d 81 9 number number NN cord-022053-idft1p6d 81 10 increased increase VBD cord-022053-idft1p6d 81 11 to to IN cord-022053-idft1p6d 81 12 76.9 76.9 CD cord-022053-idft1p6d 81 13 % % NN cord-022053-idft1p6d 81 14 . . . cord-022053-idft1p6d 82 1 In in IN cord-022053-idft1p6d 82 2 addition addition NN cord-022053-idft1p6d 82 3 , , , cord-022053-idft1p6d 82 4 20.8 20.8 CD cord-022053-idft1p6d 82 5 % % NN cord-022053-idft1p6d 82 6 of of IN cord-022053-idft1p6d 82 7 the the DT cord-022053-idft1p6d 82 8 non non JJ cord-022053-idft1p6d 82 9 - - JJ cord-022053-idft1p6d 82 10 fragilis fragilis JJ cord-022053-idft1p6d 82 11 Bacteroides Bacteroides NNP cord-022053-idft1p6d 82 12 spp spp NNS cord-022053-idft1p6d 82 13 . . . cord-022053-idft1p6d 82 14 was be VBD cord-022053-idft1p6d 82 15 misidentified misidentifie VBN cord-022053-idft1p6d 82 16 as as IN cord-022053-idft1p6d 82 17 other other JJ cord-022053-idft1p6d 82 18 Bacteroides Bacteroides NNP cord-022053-idft1p6d 82 19 , , , cord-022053-idft1p6d 82 20 with with IN cord-022053-idft1p6d 82 21 high high JJ cord-022053-idft1p6d 82 22 confidence confidence NN cord-022053-idft1p6d 82 23 scores score NNS cord-022053-idft1p6d 82 24 , , , cord-022053-idft1p6d 82 25 and and CC cord-022053-idft1p6d 82 26 only only RB cord-022053-idft1p6d 82 27 52.9 52.9 CD cord-022053-idft1p6d 82 28 % % NN cord-022053-idft1p6d 82 29 of of IN cord-022053-idft1p6d 82 30 the the DT cord-022053-idft1p6d 82 31 gram gram NN cord-022053-idft1p6d 82 32 - - HYPH cord-022053-idft1p6d 82 33 positive positive JJ cord-022053-idft1p6d 82 34 anaerobic anaerobic JJ cord-022053-idft1p6d 82 35 cocci coccus NNS cord-022053-idft1p6d 82 36 were be VBD cord-022053-idft1p6d 82 37 correctly correctly RB cord-022053-idft1p6d 82 38 identified identify VBN cord-022053-idft1p6d 82 39 to to IN cord-022053-idft1p6d 82 40 the the DT cord-022053-idft1p6d 82 41 species species NN cord-022053-idft1p6d 82 42 level level NN cord-022053-idft1p6d 82 43 . . . cord-022053-idft1p6d 83 1 The the DT cord-022053-idft1p6d 83 2 latter latter JJ cord-022053-idft1p6d 83 3 was be VBD cord-022053-idft1p6d 83 4 mostly mostly RB cord-022053-idft1p6d 83 5 a a DT cord-022053-idft1p6d 83 6 function function NN cord-022053-idft1p6d 83 7 of of IN cord-022053-idft1p6d 83 8 poor poor JJ cord-022053-idft1p6d 83 9 performance performance NN cord-022053-idft1p6d 83 10 on on IN cord-022053-idft1p6d 83 11 several several JJ cord-022053-idft1p6d 83 12 species specie NNS cord-022053-idft1p6d 83 13 of of IN cord-022053-idft1p6d 83 14 Peptoniphilus Peptoniphilus NNP cord-022053-idft1p6d 83 15 . . . cord-022053-idft1p6d 84 1 15 15 CD cord-022053-idft1p6d 85 1 Interestingly interestingly RB cord-022053-idft1p6d 85 2 , , , cord-022053-idft1p6d 85 3 in in IN cord-022053-idft1p6d 85 4 a a DT cord-022053-idft1p6d 85 5 dedicated dedicated JJ cord-022053-idft1p6d 85 6 study study NN cord-022053-idft1p6d 85 7 looking look VBG cord-022053-idft1p6d 85 8 at at IN cord-022053-idft1p6d 85 9 the the DT cord-022053-idft1p6d 85 10 performance performance NN cord-022053-idft1p6d 85 11 of of IN cord-022053-idft1p6d 85 12 the the DT cord-022053-idft1p6d 85 13 Biotyper Biotyper NNP cord-022053-idft1p6d 85 14 ( ( -LRB- cord-022053-idft1p6d 85 15 2.0 2.0 CD cord-022053-idft1p6d 85 16 ) ) -RRB- cord-022053-idft1p6d 85 17 on on IN cord-022053-idft1p6d 85 18 a a DT cord-022053-idft1p6d 85 19 collection collection NN cord-022053-idft1p6d 85 20 of of IN cord-022053-idft1p6d 85 21 277 277 CD cord-022053-idft1p6d 85 22 isolates isolate NNS cord-022053-idft1p6d 85 23 of of IN cord-022053-idft1p6d 85 24 Bacteroides Bacteroides NNP cord-022053-idft1p6d 85 25 spp spp NNS cord-022053-idft1p6d 85 26 . . . cord-022053-idft1p6d 86 1 , , , cord-022053-idft1p6d 86 2 97.5 97.5 CD cord-022053-idft1p6d 86 3 % % NN cord-022053-idft1p6d 86 4 were be VBD cord-022053-idft1p6d 86 5 correctly correctly RB cord-022053-idft1p6d 86 6 identified identify VBN cord-022053-idft1p6d 86 7 to to IN cord-022053-idft1p6d 86 8 the the DT cord-022053-idft1p6d 86 9 species species NN cord-022053-idft1p6d 86 10 level level NN cord-022053-idft1p6d 86 11 . . . cord-022053-idft1p6d 87 1 16 16 CD cord-022053-idft1p6d 88 1 The the DT cord-022053-idft1p6d 88 2 identification identification NN cord-022053-idft1p6d 88 3 of of IN cord-022053-idft1p6d 88 4 yeasts yeast NNS cord-022053-idft1p6d 88 5 is be VBZ cord-022053-idft1p6d 88 6 an an DT cord-022053-idft1p6d 88 7 FDA FDA NNP cord-022053-idft1p6d 88 8 - - HYPH cord-022053-idft1p6d 88 9 approved approve VBN cord-022053-idft1p6d 88 10 application application NN cord-022053-idft1p6d 88 11 for for IN cord-022053-idft1p6d 88 12 both both CC cord-022053-idft1p6d 88 13 the the DT cord-022053-idft1p6d 88 14 Biotyper Biotyper NNP cord-022053-idft1p6d 88 15 and and CC cord-022053-idft1p6d 88 16 Vitek Vitek NNP cord-022053-idft1p6d 88 17 MS MS NNP cord-022053-idft1p6d 88 18 . . . cord-022053-idft1p6d 89 1 Both both DT cord-022053-idft1p6d 89 2 systems system NNS cord-022053-idft1p6d 89 3 have have VBP cord-022053-idft1p6d 89 4 demonstrated demonstrate VBN cord-022053-idft1p6d 89 5 strong strong JJ cord-022053-idft1p6d 89 6 performance performance NN cord-022053-idft1p6d 89 7 in in IN cord-022053-idft1p6d 89 8 multiple multiple JJ cord-022053-idft1p6d 89 9 studies study NNS cord-022053-idft1p6d 89 10 , , , cord-022053-idft1p6d 89 11 reviewed review VBN cord-022053-idft1p6d 89 12 by by IN cord-022053-idft1p6d 89 13 Cassagne Cassagne NNP cord-022053-idft1p6d 89 14 et et FW cord-022053-idft1p6d 89 15 al al NNP cord-022053-idft1p6d 89 16 . . . cord-022053-idft1p6d 90 1 17 17 CD cord-022053-idft1p6d 91 1 One one CD cord-022053-idft1p6d 91 2 recent recent JJ cord-022053-idft1p6d 91 3 study study NN cord-022053-idft1p6d 91 4 with with IN cord-022053-idft1p6d 91 5 the the DT cord-022053-idft1p6d 91 6 Biotyper Biotyper NNP cord-022053-idft1p6d 91 7 , , , cord-022053-idft1p6d 91 8 for for IN cord-022053-idft1p6d 91 9 example example NN cord-022053-idft1p6d 91 10 , , , cord-022053-idft1p6d 91 11 used use VBD cord-022053-idft1p6d 91 12 a a DT cord-022053-idft1p6d 91 13 library library NN cord-022053-idft1p6d 91 14 of of IN cord-022053-idft1p6d 91 15 303 303 CD cord-022053-idft1p6d 91 16 clinical clinical JJ cord-022053-idft1p6d 91 17 isolates isolate NNS cord-022053-idft1p6d 91 18 representing represent VBG cord-022053-idft1p6d 91 19 a a DT cord-022053-idft1p6d 91 20 diverse diverse JJ cord-022053-idft1p6d 91 21 array array NN cord-022053-idft1p6d 91 22 of of IN cord-022053-idft1p6d 91 23 yeasts yeast NNS cord-022053-idft1p6d 91 24 and and CC cord-022053-idft1p6d 91 25 found find VBD cord-022053-idft1p6d 91 26 an an DT cord-022053-idft1p6d 91 27 agreement agreement NN cord-022053-idft1p6d 91 28 with with IN cord-022053-idft1p6d 91 29 standard standard JJ cord-022053-idft1p6d 91 30 methods method NNS cord-022053-idft1p6d 91 31 in in IN cord-022053-idft1p6d 91 32 84.8 84.8 CD cord-022053-idft1p6d 91 33 % % NN cord-022053-idft1p6d 91 34 . . . cord-022053-idft1p6d 92 1 18 18 CD cord-022053-idft1p6d 93 1 In in IN cord-022053-idft1p6d 93 2 an an DT cord-022053-idft1p6d 93 3 additional additional JJ cord-022053-idft1p6d 93 4 26 26 CD cord-022053-idft1p6d 93 5 isolates isolate NNS cord-022053-idft1p6d 93 6 the the DT cord-022053-idft1p6d 93 7 Biotyper Biotyper NNP cord-022053-idft1p6d 93 8 returned return VBD cord-022053-idft1p6d 93 9 a a DT cord-022053-idft1p6d 93 10 result result NN cord-022053-idft1p6d 93 11 that that WDT cord-022053-idft1p6d 93 12 was be VBD cord-022053-idft1p6d 93 13 confirmed confirm VBN cord-022053-idft1p6d 93 14 as as IN cord-022053-idft1p6d 93 15 true true JJ cord-022053-idft1p6d 93 16 by by IN cord-022053-idft1p6d 93 17 sequencing sequence VBG cord-022053-idft1p6d 93 18 in in IN cord-022053-idft1p6d 93 19 21 21 CD cord-022053-idft1p6d 93 20 . . . cord-022053-idft1p6d 94 1 The the DT cord-022053-idft1p6d 94 2 Biotyper Biotyper NNP cord-022053-idft1p6d 94 3 failed fail VBD cord-022053-idft1p6d 94 4 to to TO cord-022053-idft1p6d 94 5 make make VB cord-022053-idft1p6d 94 6 identification identification NN cord-022053-idft1p6d 94 7 in in IN cord-022053-idft1p6d 94 8 an an DT cord-022053-idft1p6d 94 9 additional additional JJ cord-022053-idft1p6d 94 10 20 20 CD cord-022053-idft1p6d 94 11 isolates isolate NNS cord-022053-idft1p6d 94 12 . . . cord-022053-idft1p6d 95 1 Bader Bader NNP cord-022053-idft1p6d 95 2 et et NNP cord-022053-idft1p6d 95 3 al al NNP cord-022053-idft1p6d 95 4 . . NNP cord-022053-idft1p6d 95 5 used use VBD cord-022053-idft1p6d 95 6 an an DT cord-022053-idft1p6d 95 7 even even RB cord-022053-idft1p6d 95 8 larger large JJR cord-022053-idft1p6d 95 9 cohort cohort NN cord-022053-idft1p6d 95 10 of of IN cord-022053-idft1p6d 95 11 clinical clinical JJ cord-022053-idft1p6d 95 12 yeast yeast NN cord-022053-idft1p6d 95 13 isolates isolate NNS cord-022053-idft1p6d 95 14 ( ( -LRB- cord-022053-idft1p6d 95 15 1192 1192 CD cord-022053-idft1p6d 95 16 ) ) -RRB- cord-022053-idft1p6d 95 17 to to TO cord-022053-idft1p6d 95 18 compare compare VB cord-022053-idft1p6d 95 19 the the DT cord-022053-idft1p6d 95 20 performance performance NN cord-022053-idft1p6d 95 21 of of IN cord-022053-idft1p6d 95 22 traditional traditional JJ cord-022053-idft1p6d 95 23 methods method NNS cord-022053-idft1p6d 95 24 with with IN cord-022053-idft1p6d 95 25 the the DT cord-022053-idft1p6d 95 26 Bruker Bruker NNP cord-022053-idft1p6d 95 27 Biotyper Biotyper NNP cord-022053-idft1p6d 95 28 and and CC cord-022053-idft1p6d 95 29 the the DT cord-022053-idft1p6d 95 30 Vitek Vitek NNP cord-022053-idft1p6d 95 31 SARAMIS SARAMIS NNP cord-022053-idft1p6d 95 32 ( ( -LRB- cord-022053-idft1p6d 95 33 research research NN cord-022053-idft1p6d 95 34 use use NN cord-022053-idft1p6d 95 35 only only RB cord-022053-idft1p6d 95 36 database database NN cord-022053-idft1p6d 95 37 ) ) -RRB- cord-022053-idft1p6d 95 38 . . . cord-022053-idft1p6d 96 1 They -PRON- PRP cord-022053-idft1p6d 96 2 found find VBD cord-022053-idft1p6d 96 3 an an DT cord-022053-idft1p6d 96 4 overall overall JJ cord-022053-idft1p6d 96 5 agreement agreement NN cord-022053-idft1p6d 96 6 between between IN cord-022053-idft1p6d 96 7 the the DT cord-022053-idft1p6d 96 8 methods method NNS cord-022053-idft1p6d 96 9 of of IN cord-022053-idft1p6d 96 10 95.1 95.1 CD cord-022053-idft1p6d 96 11 % % NN cord-022053-idft1p6d 96 12 and and CC cord-022053-idft1p6d 96 13 noted note VBD cord-022053-idft1p6d 96 14 not not RB cord-022053-idft1p6d 96 15 only only RB cord-022053-idft1p6d 96 16 that that IN cord-022053-idft1p6d 96 17 both both DT cord-022053-idft1p6d 96 18 MALDI MALDI NNS cord-022053-idft1p6d 96 19 methods method NNS cord-022053-idft1p6d 96 20 were be VBD cord-022053-idft1p6d 96 21 able able JJ cord-022053-idft1p6d 96 22 to to TO cord-022053-idft1p6d 96 23 discriminate discriminate VB cord-022053-idft1p6d 96 24 species specie NNS cord-022053-idft1p6d 96 25 that that IN cord-022053-idft1p6d 96 26 traditional traditional JJ cord-022053-idft1p6d 96 27 methods method NNS cord-022053-idft1p6d 96 28 could could MD cord-022053-idft1p6d 96 29 not not RB cord-022053-idft1p6d 96 30 , , , cord-022053-idft1p6d 96 31 but but CC cord-022053-idft1p6d 96 32 that that IN cord-022053-idft1p6d 96 33 the the DT cord-022053-idft1p6d 96 34 savings saving NNS cord-022053-idft1p6d 96 35 in in IN cord-022053-idft1p6d 96 36 time time NN cord-022053-idft1p6d 96 37 and and CC cord-022053-idft1p6d 96 38 money money NN cord-022053-idft1p6d 96 39 were be VBD cord-022053-idft1p6d 96 40 substantial substantial JJ cord-022053-idft1p6d 96 41 . . . cord-022053-idft1p6d 97 1 19 19 CD cord-022053-idft1p6d 98 1 More more RBR cord-022053-idft1p6d 98 2 recently recently RB cord-022053-idft1p6d 98 3 , , , cord-022053-idft1p6d 98 4 Chao Chao NNP cord-022053-idft1p6d 98 5 et et NNP cord-022053-idft1p6d 98 6 al al NNP cord-022053-idft1p6d 98 7 . . . cord-022053-idft1p6d 98 8 analyzed analyze VBD cord-022053-idft1p6d 98 9 a a DT cord-022053-idft1p6d 98 10 collection collection NN cord-022053-idft1p6d 98 11 of of IN cord-022053-idft1p6d 98 12 200 200 CD cord-022053-idft1p6d 98 13 clinical clinical JJ cord-022053-idft1p6d 98 14 yeast yeast NN cord-022053-idft1p6d 98 15 isolates isolate NNS cord-022053-idft1p6d 98 16 with with IN cord-022053-idft1p6d 98 17 both both CC cord-022053-idft1p6d 98 18 the the DT cord-022053-idft1p6d 98 19 Biotyper Biotyper NNP cord-022053-idft1p6d 98 20 and and CC cord-022053-idft1p6d 98 21 the the DT cord-022053-idft1p6d 98 22 Vitek Vitek NNP cord-022053-idft1p6d 98 23 MS MS NNP cord-022053-idft1p6d 98 24 . . . cord-022053-idft1p6d 99 1 20 20 CD cord-022053-idft1p6d 100 1 They -PRON- PRP cord-022053-idft1p6d 100 2 found find VBD cord-022053-idft1p6d 100 3 that that IN cord-022053-idft1p6d 100 4 the the DT cord-022053-idft1p6d 100 5 Biotyper Biotyper NNP cord-022053-idft1p6d 100 6 slightly slightly RB cord-022053-idft1p6d 100 7 outperformed outperform VBD cord-022053-idft1p6d 100 8 the the DT cord-022053-idft1p6d 100 9 Vitek Vitek NNP cord-022053-idft1p6d 100 10 MS MS NNP cord-022053-idft1p6d 100 11 ( ( -LRB- cord-022053-idft1p6d 100 12 92.5 92.5 CD cord-022053-idft1p6d 100 13 % % NN cord-022053-idft1p6d 100 14 vs vs IN cord-022053-idft1p6d 100 15 79.5 79.5 CD cord-022053-idft1p6d 100 16 % % NN cord-022053-idft1p6d 100 17 correctly correctly RB cord-022053-idft1p6d 100 18 identified identify VBN cord-022053-idft1p6d 100 19 to to IN cord-022053-idft1p6d 100 20 the the DT cord-022053-idft1p6d 100 21 species specie NNS cord-022053-idft1p6d 100 22 or or CC cord-022053-idft1p6d 100 23 complex complex JJ cord-022053-idft1p6d 100 24 level level NN cord-022053-idft1p6d 100 25 ) ) -RRB- cord-022053-idft1p6d 100 26 . . . cord-022053-idft1p6d 101 1 This this DT cord-022053-idft1p6d 101 2 compared compare VBN cord-022053-idft1p6d 101 3 with with IN cord-022053-idft1p6d 101 4 rates rate NNS cord-022053-idft1p6d 101 5 of of IN cord-022053-idft1p6d 101 6 89 89 CD cord-022053-idft1p6d 101 7 % % NN cord-022053-idft1p6d 101 8 and and CC cord-022053-idft1p6d 101 9 74 74 CD cord-022053-idft1p6d 101 10 % % NN cord-022053-idft1p6d 101 11 for for IN cord-022053-idft1p6d 101 12 two two CD cord-022053-idft1p6d 101 13 common common JJ cord-022053-idft1p6d 101 14 phenotypic phenotypic JJ cord-022053-idft1p6d 101 15 methods method NNS cord-022053-idft1p6d 101 16 ( ( -LRB- cord-022053-idft1p6d 101 17 Phoenix Phoenix NNP cord-022053-idft1p6d 101 18 100 100 CD cord-022053-idft1p6d 101 19 YBC YBC NNP cord-022053-idft1p6d 101 20 and and CC cord-022053-idft1p6d 101 21 the the DT cord-022053-idft1p6d 101 22 Vitek Vitek NNP cord-022053-idft1p6d 101 23 2 2 CD cord-022053-idft1p6d 101 24 Yeast Yeast NNP cord-022053-idft1p6d 101 25 ID ID NNP cord-022053-idft1p6d 101 26 , , , cord-022053-idft1p6d 101 27 respectively respectively RB cord-022053-idft1p6d 101 28 ) ) -RRB- cord-022053-idft1p6d 101 29 . . . cord-022053-idft1p6d 102 1 This this DT cord-022053-idft1p6d 102 2 trend trend NN cord-022053-idft1p6d 102 3 was be VBD cord-022053-idft1p6d 102 4 also also RB cord-022053-idft1p6d 102 5 observed observe VBN cord-022053-idft1p6d 102 6 by by IN cord-022053-idft1p6d 102 7 Mancini Mancini NNP cord-022053-idft1p6d 102 8 et et NNP cord-022053-idft1p6d 102 9 al al NNP cord-022053-idft1p6d 102 10 . . NNP cord-022053-idft1p6d 102 11 , , , cord-022053-idft1p6d 102 12 who who WP cord-022053-idft1p6d 102 13 used use VBD cord-022053-idft1p6d 102 14 a a DT cord-022053-idft1p6d 102 15 collection collection NN cord-022053-idft1p6d 102 16 of of IN cord-022053-idft1p6d 102 17 197 197 CD cord-022053-idft1p6d 102 18 clinical clinical JJ cord-022053-idft1p6d 102 19 yeast yeast NN cord-022053-idft1p6d 102 20 isolates isolate NNS cord-022053-idft1p6d 102 21 , , , cord-022053-idft1p6d 102 22 which which WDT cord-022053-idft1p6d 102 23 included include VBD cord-022053-idft1p6d 102 24 157 157 CD cord-022053-idft1p6d 102 25 Candida Candida NNP cord-022053-idft1p6d 102 26 or or CC cord-022053-idft1p6d 102 27 related relate VBN cord-022053-idft1p6d 102 28 species specie NNS cord-022053-idft1p6d 102 29 and and CC cord-022053-idft1p6d 102 30 40 40 CD cord-022053-idft1p6d 102 31 non non JJ cord-022053-idft1p6d 102 32 - - JJ cord-022053-idft1p6d 102 33 Candida candida JJ cord-022053-idft1p6d 102 34 species specie NNS cord-022053-idft1p6d 102 35 . . . cord-022053-idft1p6d 103 1 They -PRON- PRP cord-022053-idft1p6d 103 2 found find VBD cord-022053-idft1p6d 103 3 that that IN cord-022053-idft1p6d 103 4 the the DT cord-022053-idft1p6d 103 5 Biotyper Biotyper NNP cord-022053-idft1p6d 103 6 identified identify VBD cord-022053-idft1p6d 103 7 89.8 89.8 CD cord-022053-idft1p6d 103 8 % % NN cord-022053-idft1p6d 103 9 of of IN cord-022053-idft1p6d 103 10 isolates isolate NNS cord-022053-idft1p6d 103 11 , , , cord-022053-idft1p6d 103 12 whereas whereas IN cord-022053-idft1p6d 103 13 the the DT cord-022053-idft1p6d 103 14 Vitek Vitek NNP cord-022053-idft1p6d 103 15 MS MS NNP cord-022053-idft1p6d 103 16 identified identify VBD cord-022053-idft1p6d 103 17 84.3 84.3 CD cord-022053-idft1p6d 103 18 % % NN cord-022053-idft1p6d 103 19 using use VBG cord-022053-idft1p6d 103 20 the the DT cord-022053-idft1p6d 103 21 standard standard NN cord-022053-idft1p6d 103 22 commercially commercially RB cord-022053-idft1p6d 103 23 available available JJ cord-022053-idft1p6d 103 24 database database NN cord-022053-idft1p6d 103 25 . . . cord-022053-idft1p6d 104 1 Importantly importantly RB cord-022053-idft1p6d 104 2 , , , cord-022053-idft1p6d 104 3 the the DT cord-022053-idft1p6d 104 4 Vitek Vitek NNP cord-022053-idft1p6d 104 5 MS MS NNP cord-022053-idft1p6d 104 6 had have VBD cord-022053-idft1p6d 104 7 a a DT cord-022053-idft1p6d 104 8 much much RB cord-022053-idft1p6d 104 9 higher high JJR cord-022053-idft1p6d 104 10 rate rate NN cord-022053-idft1p6d 104 11 of of IN cord-022053-idft1p6d 104 12 misidentification misidentification NN cord-022053-idft1p6d 104 13 ( ( -LRB- cord-022053-idft1p6d 104 14 12.1 12.1 CD cord-022053-idft1p6d 104 15 % % NN cord-022053-idft1p6d 104 16 vs vs IN cord-022053-idft1p6d 104 17 1 1 CD cord-022053-idft1p6d 104 18 % % NN cord-022053-idft1p6d 104 19 ) ) -RRB- cord-022053-idft1p6d 104 20 . . . cord-022053-idft1p6d 105 1 21 21 CD cord-022053-idft1p6d 106 1 In in IN cord-022053-idft1p6d 106 2 general general JJ cord-022053-idft1p6d 106 3 , , , cord-022053-idft1p6d 106 4 it -PRON- PRP cord-022053-idft1p6d 106 5 has have VBZ cord-022053-idft1p6d 106 6 been be VBN cord-022053-idft1p6d 106 7 found find VBN cord-022053-idft1p6d 106 8 that that IN cord-022053-idft1p6d 106 9 a a DT cord-022053-idft1p6d 106 10 formic formic JJ cord-022053-idft1p6d 106 11 acid acid NN cord-022053-idft1p6d 106 12 / / SYM cord-022053-idft1p6d 106 13 ethanol ethanol NN cord-022053-idft1p6d 106 14 on on IN cord-022053-idft1p6d 106 15 the the DT cord-022053-idft1p6d 106 16 organism organism NN cord-022053-idft1p6d 106 17 in in IN cord-022053-idft1p6d 106 18 question question NN cord-022053-idft1p6d 106 19 ) ) -RRB- cord-022053-idft1p6d 106 20 . . . cord-022053-idft1p6d 107 1 5 5 LS cord-022053-idft1p6d 107 2 , , , cord-022053-idft1p6d 107 3 7 7 CD cord-022053-idft1p6d 107 4 Other other JJ cord-022053-idft1p6d 107 5 benefits benefit NNS cord-022053-idft1p6d 107 6 to to IN cord-022053-idft1p6d 107 7 MALDI MALDI NNS cord-022053-idft1p6d 107 8 in in IN cord-022053-idft1p6d 107 9 routine routine JJ cord-022053-idft1p6d 107 10 clinical clinical JJ cord-022053-idft1p6d 107 11 microbiology microbiology NN cord-022053-idft1p6d 107 12 include include VBP cord-022053-idft1p6d 107 13 low low JJ cord-022053-idft1p6d 107 14 costs cost NNS cord-022053-idft1p6d 107 15 of of IN cord-022053-idft1p6d 107 16 reagents reagent NNS cord-022053-idft1p6d 107 17 and and CC cord-022053-idft1p6d 107 18 less less JJR cord-022053-idft1p6d 107 19 production production NN cord-022053-idft1p6d 107 20 of of IN cord-022053-idft1p6d 107 21 waste waste NN cord-022053-idft1p6d 107 22 materials material NNS cord-022053-idft1p6d 107 23 ( ( -LRB- cord-022053-idft1p6d 107 24 reduced reduce VBN cord-022053-idft1p6d 107 25 consumables consumable NNS cord-022053-idft1p6d 107 26 ) ) -RRB- cord-022053-idft1p6d 107 27 . . . cord-022053-idft1p6d 108 1 There there EX cord-022053-idft1p6d 108 2 are be VBP cord-022053-idft1p6d 108 3 a a DT cord-022053-idft1p6d 108 4 few few JJ cord-022053-idft1p6d 108 5 shortcomings shortcoming NNS cord-022053-idft1p6d 108 6 of of IN cord-022053-idft1p6d 108 7 this this DT cord-022053-idft1p6d 108 8 technology technology NN cord-022053-idft1p6d 108 9 . . . cord-022053-idft1p6d 109 1 For for IN cord-022053-idft1p6d 109 2 the the DT cord-022053-idft1p6d 109 3 most most JJS cord-022053-idft1p6d 109 4 part part NN cord-022053-idft1p6d 109 5 , , , cord-022053-idft1p6d 109 6 MALDI MALDI NNP cord-022053-idft1p6d 109 7 is be VBZ cord-022053-idft1p6d 109 8 limited limit VBN cord-022053-idft1p6d 109 9 to to IN cord-022053-idft1p6d 109 10 cultured cultured JJ cord-022053-idft1p6d 109 11 isolates isolate NNS cord-022053-idft1p6d 109 12 , , , cord-022053-idft1p6d 109 13 so so IN cord-022053-idft1p6d 109 14 although although IN cord-022053-idft1p6d 109 15 it -PRON- PRP cord-022053-idft1p6d 109 16 offers offer VBZ cord-022053-idft1p6d 109 17 tremendous tremendous JJ cord-022053-idft1p6d 109 18 TAT tat NN cord-022053-idft1p6d 109 19 advantages advantage NNS cord-022053-idft1p6d 109 20 it -PRON- PRP cord-022053-idft1p6d 109 21 is be VBZ cord-022053-idft1p6d 109 22 inherently inherently RB cord-022053-idft1p6d 109 23 limited limit VBN cord-022053-idft1p6d 109 24 by by IN cord-022053-idft1p6d 109 25 the the DT cord-022053-idft1p6d 109 26 time time NN cord-022053-idft1p6d 109 27 to to IN cord-022053-idft1p6d 109 28 growth growth NN cord-022053-idft1p6d 109 29 of of IN cord-022053-idft1p6d 109 30 the the DT cord-022053-idft1p6d 109 31 organism organism NN cord-022053-idft1p6d 109 32 . . . cord-022053-idft1p6d 110 1 Sparse sparse JJ cord-022053-idft1p6d 110 2 database database NN cord-022053-idft1p6d 110 3 coverage coverage NN cord-022053-idft1p6d 110 4 over over IN cord-022053-idft1p6d 110 5 certain certain JJ cord-022053-idft1p6d 110 6 phyla phylum NNS cord-022053-idft1p6d 110 7 ( ( -LRB- cord-022053-idft1p6d 110 8 e.g. e.g. RB cord-022053-idft1p6d 110 9 , , , cord-022053-idft1p6d 110 10 filamentous filamentous JJ cord-022053-idft1p6d 110 11 fungi fungus NNS cord-022053-idft1p6d 110 12 , , , cord-022053-idft1p6d 110 13 some some DT cord-022053-idft1p6d 110 14 anaerobes anaerobe NNS cord-022053-idft1p6d 110 15 ) ) -RRB- cord-022053-idft1p6d 110 16 presents present VBZ cord-022053-idft1p6d 110 17 an an DT cord-022053-idft1p6d 110 18 issue issue NN cord-022053-idft1p6d 110 19 in in IN cord-022053-idft1p6d 110 20 some some DT cord-022053-idft1p6d 110 21 cases case NNS cord-022053-idft1p6d 110 22 , , , cord-022053-idft1p6d 110 23 although although IN cord-022053-idft1p6d 110 24 commercially commercially RB cord-022053-idft1p6d 110 25 available available JJ cord-022053-idft1p6d 110 26 libraries library NNS cord-022053-idft1p6d 110 27 continue continue VBP cord-022053-idft1p6d 110 28 to to TO cord-022053-idft1p6d 110 29 be be VB cord-022053-idft1p6d 110 30 expanded expand VBN cord-022053-idft1p6d 110 31 . . . cord-022053-idft1p6d 111 1 Another another DT cord-022053-idft1p6d 111 2 major major JJ cord-022053-idft1p6d 111 3 caveat caveat NN cord-022053-idft1p6d 111 4 of of IN cord-022053-idft1p6d 111 5 MALDI MALDI NNP cord-022053-idft1p6d 111 6 is be VBZ cord-022053-idft1p6d 111 7 that that IN cord-022053-idft1p6d 111 8 it -PRON- PRP cord-022053-idft1p6d 111 9 is be VBZ cord-022053-idft1p6d 111 10 not not RB cord-022053-idft1p6d 111 11 yet yet RB cord-022053-idft1p6d 111 12 a a DT cord-022053-idft1p6d 111 13 practical practical JJ cord-022053-idft1p6d 111 14 method method NN cord-022053-idft1p6d 111 15 for for IN cord-022053-idft1p6d 111 16 assessing assess VBG cord-022053-idft1p6d 111 17 antibiotic antibiotic JJ cord-022053-idft1p6d 111 18 resistance resistance NN cord-022053-idft1p6d 111 19 . . . cord-022053-idft1p6d 112 1 Direct direct JJ cord-022053-idft1p6d 112 2 detection detection NN cord-022053-idft1p6d 112 3 of of IN cord-022053-idft1p6d 112 4 resistance resistance NN cord-022053-idft1p6d 112 5 - - HYPH cord-022053-idft1p6d 112 6 conferring confer VBG cord-022053-idft1p6d 112 7 enzymes enzyme NNS cord-022053-idft1p6d 112 8 is be VBZ cord-022053-idft1p6d 112 9 not not RB cord-022053-idft1p6d 112 10 practical practical JJ cord-022053-idft1p6d 112 11 within within IN cord-022053-idft1p6d 112 12 the the DT cord-022053-idft1p6d 112 13 assay assay NN cord-022053-idft1p6d 112 14 's 's POS cord-022053-idft1p6d 112 15 limits limit NNS cord-022053-idft1p6d 112 16 of of IN cord-022053-idft1p6d 112 17 detection detection NN cord-022053-idft1p6d 112 18 ; ; : cord-022053-idft1p6d 112 19 however however RB cord-022053-idft1p6d 112 20 , , , cord-022053-idft1p6d 112 21 some some DT cord-022053-idft1p6d 112 22 promising promising JJ cord-022053-idft1p6d 112 23 studies study NNS cord-022053-idft1p6d 112 24 have have VBP cord-022053-idft1p6d 112 25 been be VBN cord-022053-idft1p6d 112 26 published publish VBN cord-022053-idft1p6d 112 27 looking look VBG cord-022053-idft1p6d 112 28 at at IN cord-022053-idft1p6d 112 29 the the DT cord-022053-idft1p6d 112 30 ability ability NN cord-022053-idft1p6d 112 31 of of IN cord-022053-idft1p6d 112 32 MALDI MALDI NNS cord-022053-idft1p6d 112 33 to to TO cord-022053-idft1p6d 112 34 detect detect VB cord-022053-idft1p6d 112 35 breakdown breakdown NN cord-022053-idft1p6d 112 36 products product NNS cord-022053-idft1p6d 112 37 after after IN cord-022053-idft1p6d 112 38 incubation incubation NN cord-022053-idft1p6d 112 39 in in IN cord-022053-idft1p6d 112 40 the the DT cord-022053-idft1p6d 112 41 presence presence NN cord-022053-idft1p6d 112 42 of of IN cord-022053-idft1p6d 112 43 antibiotic antibiotic NN cord-022053-idft1p6d 112 44 . . . cord-022053-idft1p6d 113 1 3 3 LS cord-022053-idft1p6d 114 1 However however RB cord-022053-idft1p6d 114 2 , , , cord-022053-idft1p6d 114 3 resistance resistance NN cord-022053-idft1p6d 114 4 testing testing NN cord-022053-idft1p6d 114 5 is be VBZ cord-022053-idft1p6d 114 6 unlikely unlikely JJ cord-022053-idft1p6d 114 7 to to TO cord-022053-idft1p6d 114 8 be be VB cord-022053-idft1p6d 114 9 incorporated incorporate VBN cord-022053-idft1p6d 114 10 into into IN cord-022053-idft1p6d 114 11 a a DT cord-022053-idft1p6d 114 12 standard standard JJ cord-022053-idft1p6d 114 13 MALDI MALDI NNP cord-022053-idft1p6d 114 14 microbial microbial JJ cord-022053-idft1p6d 114 15 identification identification NN cord-022053-idft1p6d 114 16 platform platform NN cord-022053-idft1p6d 114 17 in in IN cord-022053-idft1p6d 114 18 the the DT cord-022053-idft1p6d 114 19 near near JJ cord-022053-idft1p6d 114 20 future future NN cord-022053-idft1p6d 114 21 . . . cord-022053-idft1p6d 115 1 Mass mass NN cord-022053-idft1p6d 115 2 spectroscopy spectroscopy NN cord-022053-idft1p6d 115 3 has have VBZ cord-022053-idft1p6d 115 4 been be VBN cord-022053-idft1p6d 115 5 applied apply VBN cord-022053-idft1p6d 115 6 to to IN cord-022053-idft1p6d 115 7 human human JJ cord-022053-idft1p6d 115 8 tissues tissue NNS cord-022053-idft1p6d 115 9 , , , cord-022053-idft1p6d 115 10 including include VBG cord-022053-idft1p6d 115 11 FFPE FFPE NNP cord-022053-idft1p6d 115 12 , , , cord-022053-idft1p6d 115 13 for for IN cord-022053-idft1p6d 115 14 a a DT cord-022053-idft1p6d 115 15 variety variety NN cord-022053-idft1p6d 115 16 of of IN cord-022053-idft1p6d 115 17 purposes purpose NNS cord-022053-idft1p6d 115 18 , , , cord-022053-idft1p6d 115 19 but but CC cord-022053-idft1p6d 115 20 , , , cord-022053-idft1p6d 115 21 to to IN cord-022053-idft1p6d 115 22 date date NN cord-022053-idft1p6d 115 23 , , , cord-022053-idft1p6d 115 24 there there EX cord-022053-idft1p6d 115 25 is be VBZ cord-022053-idft1p6d 115 26 not not RB cord-022053-idft1p6d 115 27 a a DT cord-022053-idft1p6d 115 28 commercially commercially RB cord-022053-idft1p6d 115 29 available available JJ cord-022053-idft1p6d 115 30 or or CC cord-022053-idft1p6d 115 31 routine routine JJ cord-022053-idft1p6d 115 32 method method NN cord-022053-idft1p6d 115 33 for for IN cord-022053-idft1p6d 115 34 using use VBG cord-022053-idft1p6d 115 35 MS MS NNP cord-022053-idft1p6d 115 36 in in IN cord-022053-idft1p6d 115 37 the the DT cord-022053-idft1p6d 115 38 detection detection NN cord-022053-idft1p6d 115 39 of of IN cord-022053-idft1p6d 115 40 organisms organism NNS cord-022053-idft1p6d 115 41 in in IN cord-022053-idft1p6d 115 42 FFPE FFPE NNP cord-022053-idft1p6d 115 43 . . . cord-022053-idft1p6d 116 1 44 44 CD cord-022053-idft1p6d 116 2 , , , cord-022053-idft1p6d 116 3 45 45 CD cord-022053-idft1p6d 117 1 With with IN cord-022053-idft1p6d 117 2 the the DT cord-022053-idft1p6d 117 3 advent advent NN cord-022053-idft1p6d 117 4 of of IN cord-022053-idft1p6d 117 5 rapid rapid JJ cord-022053-idft1p6d 117 6 and and CC cord-022053-idft1p6d 117 7 inexpensive inexpensive JJ cord-022053-idft1p6d 117 8 nucleic nucleic JJ cord-022053-idft1p6d 117 9 acid acid NN cord-022053-idft1p6d 117 10 methods method NNS cord-022053-idft1p6d 117 11 for for IN cord-022053-idft1p6d 117 12 FFPE FFPE NNP cord-022053-idft1p6d 117 13 , , , cord-022053-idft1p6d 117 14 this this DT cord-022053-idft1p6d 117 15 field field NN cord-022053-idft1p6d 117 16 largely largely RB cord-022053-idft1p6d 117 17 lies lie VBZ cord-022053-idft1p6d 117 18 dormant dormant JJ cord-022053-idft1p6d 117 19 , , , cord-022053-idft1p6d 117 20 although although IN cord-022053-idft1p6d 117 21 incredible incredible JJ cord-022053-idft1p6d 117 22 potential potential NN cord-022053-idft1p6d 117 23 for for IN cord-022053-idft1p6d 117 24 detection detection NN cord-022053-idft1p6d 117 25 and and CC cord-022053-idft1p6d 117 26 other other JJ cord-022053-idft1p6d 117 27 data data NN cord-022053-idft1p6d 117 28 extraction extraction NN cord-022053-idft1p6d 117 29 from from IN cord-022053-idft1p6d 117 30 FFPE FFPE NNP cord-022053-idft1p6d 117 31 through through IN cord-022053-idft1p6d 117 32 MS MS NNP cord-022053-idft1p6d 117 33 may may MD cord-022053-idft1p6d 117 34 be be VB cord-022053-idft1p6d 117 35 possible possible JJ cord-022053-idft1p6d 117 36 in in IN cord-022053-idft1p6d 117 37 the the DT cord-022053-idft1p6d 117 38 future future NN cord-022053-idft1p6d 117 39 . . . cord-022053-idft1p6d 118 1 For for IN cord-022053-idft1p6d 118 2 more more JJR cord-022053-idft1p6d 118 3 than than IN cord-022053-idft1p6d 118 4 30 30 CD cord-022053-idft1p6d 118 5 years year NNS cord-022053-idft1p6d 118 6 , , , cord-022053-idft1p6d 118 7 a a DT cord-022053-idft1p6d 118 8 wide wide JJ cord-022053-idft1p6d 118 9 spectrum spectrum NN cord-022053-idft1p6d 118 10 of of IN cord-022053-idft1p6d 118 11 assays assay NNS cord-022053-idft1p6d 118 12 based base VBN cord-022053-idft1p6d 118 13 on on IN cord-022053-idft1p6d 118 14 the the DT cord-022053-idft1p6d 118 15 detection detection NN cord-022053-idft1p6d 118 16 of of IN cord-022053-idft1p6d 118 17 nucleic nucleic JJ cord-022053-idft1p6d 118 18 acids acid NNS cord-022053-idft1p6d 118 19 has have VBZ cord-022053-idft1p6d 118 20 been be VBN cord-022053-idft1p6d 118 21 developed develop VBN cord-022053-idft1p6d 118 22 for for IN cord-022053-idft1p6d 118 23 the the DT cord-022053-idft1p6d 118 24 diagnostics diagnostic NNS cord-022053-idft1p6d 118 25 of of IN cord-022053-idft1p6d 118 26 infectious infectious JJ cord-022053-idft1p6d 118 27 disease disease NN cord-022053-idft1p6d 118 28 . . . cord-022053-idft1p6d 119 1 They -PRON- PRP cord-022053-idft1p6d 119 2 range range VBP cord-022053-idft1p6d 119 3 from from IN cord-022053-idft1p6d 119 4 simple simple JJ cord-022053-idft1p6d 119 5 probes probe NNS cord-022053-idft1p6d 119 6 to to IN cord-022053-idft1p6d 119 7 qualitative qualitative JJ cord-022053-idft1p6d 119 8 and and CC cord-022053-idft1p6d 119 9 quantitative quantitative JJ cord-022053-idft1p6d 119 10 target target NN cord-022053-idft1p6d 119 11 amplification amplification NN cord-022053-idft1p6d 119 12 to to IN cord-022053-idft1p6d 119 13 sequencing sequencing NN cord-022053-idft1p6d 119 14 . . . cord-022053-idft1p6d 120 1 For for IN cord-022053-idft1p6d 120 2 example example NN cord-022053-idft1p6d 120 3 , , , cord-022053-idft1p6d 120 4 the the DT cord-022053-idft1p6d 120 5 first first JJ cord-022053-idft1p6d 120 6 nucleic nucleic JJ cord-022053-idft1p6d 120 7 acid acid NN cord-022053-idft1p6d 120 8 probe probe NN cord-022053-idft1p6d 120 9 - - HYPH cord-022053-idft1p6d 120 10 based base VBN cord-022053-idft1p6d 120 11 assay assay NN cord-022053-idft1p6d 120 12 was be VBD cord-022053-idft1p6d 120 13 launched launch VBN cord-022053-idft1p6d 120 14 in in IN cord-022053-idft1p6d 120 15 1985 1985 CD cord-022053-idft1p6d 120 16 to to TO cord-022053-idft1p6d 120 17 test test VB cord-022053-idft1p6d 120 18 for for IN cord-022053-idft1p6d 120 19 legionnaires legionnaire NNS cord-022053-idft1p6d 120 20 ' ' POS cord-022053-idft1p6d 120 21 disease disease NN cord-022053-idft1p6d 120 22 ( ( -LRB- cord-022053-idft1p6d 120 23 Gen Gen NNP cord-022053-idft1p6d 120 24 - - HYPH cord-022053-idft1p6d 120 25 Probe Probe NNP cord-022053-idft1p6d 120 26 ) ) -RRB- cord-022053-idft1p6d 120 27 . . . cord-022053-idft1p6d 121 1 Real real JJ cord-022053-idft1p6d 121 2 - - HYPH cord-022053-idft1p6d 121 3 time time NN cord-022053-idft1p6d 121 4 platforms platform NNS cord-022053-idft1p6d 121 5 , , , cord-022053-idft1p6d 121 6 such such JJ cord-022053-idft1p6d 121 7 as as IN cord-022053-idft1p6d 121 8 the the DT cord-022053-idft1p6d 121 9 Smartcycler Smartcycler NNP cord-022053-idft1p6d 121 10 and and CC cord-022053-idft1p6d 121 11 the the DT cord-022053-idft1p6d 121 12 Lightcycler Lightcycler NNP cord-022053-idft1p6d 121 13 , , , cord-022053-idft1p6d 121 14 have have VBP cord-022053-idft1p6d 121 15 an an DT cord-022053-idft1p6d 121 16 established establish VBN cord-022053-idft1p6d 121 17 place place NN cord-022053-idft1p6d 121 18 in in IN cord-022053-idft1p6d 121 19 both both DT cord-022053-idft1p6d 121 20 detection detection NN cord-022053-idft1p6d 121 21 and and CC cord-022053-idft1p6d 121 22 quantification quantification NN cord-022053-idft1p6d 121 23 of of IN cord-022053-idft1p6d 121 24 pathogens pathogen NNS cord-022053-idft1p6d 121 25 , , , cord-022053-idft1p6d 121 26 although although IN cord-022053-idft1p6d 121 27 the the DT cord-022053-idft1p6d 121 28 major major JJ cord-022053-idft1p6d 121 29 impact impact NN cord-022053-idft1p6d 121 30 has have VBZ cord-022053-idft1p6d 121 31 mostly mostly RB cord-022053-idft1p6d 121 32 been be VBN cord-022053-idft1p6d 121 33 in in IN cord-022053-idft1p6d 121 34 virology virology NN cord-022053-idft1p6d 121 35 , , , cord-022053-idft1p6d 121 36 where where WRB cord-022053-idft1p6d 121 37 the the DT cord-022053-idft1p6d 121 38 nucleic nucleic JJ cord-022053-idft1p6d 121 39 acid acid NN cord-022053-idft1p6d 121 40 - - HYPH cord-022053-idft1p6d 121 41 based base VBN cord-022053-idft1p6d 121 42 techniques technique NNS cord-022053-idft1p6d 121 43 were be VBD cord-022053-idft1p6d 121 44 quickly quickly RB cord-022053-idft1p6d 121 45 adopted adopt VBN cord-022053-idft1p6d 121 46 to to TO cord-022053-idft1p6d 121 47 overcome overcome VB cord-022053-idft1p6d 121 48 the the DT cord-022053-idft1p6d 121 49 difficulties difficulty NNS cord-022053-idft1p6d 121 50 inherent inherent JJ cord-022053-idft1p6d 121 51 in in IN cord-022053-idft1p6d 121 52 viral viral JJ cord-022053-idft1p6d 121 53 culture culture NN cord-022053-idft1p6d 121 54 . . . cord-022053-idft1p6d 122 1 For for IN cord-022053-idft1p6d 122 2 example example NN cord-022053-idft1p6d 122 3 , , , cord-022053-idft1p6d 122 4 hepatitis hepatitis NN cord-022053-idft1p6d 122 5 C C NNP cord-022053-idft1p6d 122 6 virus virus NN cord-022053-idft1p6d 122 7 ( ( -LRB- cord-022053-idft1p6d 122 8 HCV HCV NNP cord-022053-idft1p6d 122 9 ) ) -RRB- cord-022053-idft1p6d 122 10 and and CC cord-022053-idft1p6d 122 11 HIV HIV NNP cord-022053-idft1p6d 122 12 viral viral JJ cord-022053-idft1p6d 122 13 loads load NNS cord-022053-idft1p6d 122 14 are be VBP cord-022053-idft1p6d 122 15 routine routine JJ cord-022053-idft1p6d 122 16 applications application NNS cord-022053-idft1p6d 122 17 of of IN cord-022053-idft1p6d 122 18 these these DT cord-022053-idft1p6d 122 19 technologies technology NNS cord-022053-idft1p6d 122 20 . . . cord-022053-idft1p6d 123 1 There there EX cord-022053-idft1p6d 123 2 have have VBP cord-022053-idft1p6d 123 3 been be VBN cord-022053-idft1p6d 123 4 a a DT cord-022053-idft1p6d 123 5 number number NN cord-022053-idft1p6d 123 6 of of IN cord-022053-idft1p6d 123 7 newer new JJR cord-022053-idft1p6d 123 8 nucleic nucleic JJ cord-022053-idft1p6d 123 9 acid acid NN cord-022053-idft1p6d 123 10 - - HYPH cord-022053-idft1p6d 123 11 based base VBN cord-022053-idft1p6d 123 12 technologies technology NNS cord-022053-idft1p6d 123 13 that that WDT cord-022053-idft1p6d 123 14 have have VBP cord-022053-idft1p6d 123 15 had have VBN cord-022053-idft1p6d 123 16 a a DT cord-022053-idft1p6d 123 17 tremendous tremendous JJ cord-022053-idft1p6d 123 18 impact impact NN cord-022053-idft1p6d 123 19 on on IN cord-022053-idft1p6d 123 20 microbial microbial JJ cord-022053-idft1p6d 123 21 diagnostics diagnostic NNS cord-022053-idft1p6d 123 22 , , , cord-022053-idft1p6d 123 23 many many JJ cord-022053-idft1p6d 123 24 of of IN cord-022053-idft1p6d 123 25 which which WDT cord-022053-idft1p6d 123 26 are be VBP cord-022053-idft1p6d 123 27 also also RB cord-022053-idft1p6d 123 28 geared gear VBN cord-022053-idft1p6d 123 29 towards towards IN cord-022053-idft1p6d 123 30 bacterial bacterial JJ cord-022053-idft1p6d 123 31 pathogens pathogen NNS cord-022053-idft1p6d 123 32 . . . cord-022053-idft1p6d 124 1 These these DT cord-022053-idft1p6d 124 2 include include VBP cord-022053-idft1p6d 124 3 highly highly RB cord-022053-idft1p6d 124 4 sensitive sensitive JJ cord-022053-idft1p6d 124 5 probes probe NNS cord-022053-idft1p6d 124 6 for for IN cord-022053-idft1p6d 124 7 use use NN cord-022053-idft1p6d 124 8 in in IN cord-022053-idft1p6d 124 9 direct direct JJ cord-022053-idft1p6d 124 10 specimens specimen NNS cord-022053-idft1p6d 124 11 , , , cord-022053-idft1p6d 124 12 to to IN cord-022053-idft1p6d 124 13 alternative alternative JJ cord-022053-idft1p6d 124 14 amplification amplification NN cord-022053-idft1p6d 124 15 methods method NNS cord-022053-idft1p6d 124 16 , , , cord-022053-idft1p6d 124 17 rapid rapid JJ cord-022053-idft1p6d 124 18 assays assay NNS cord-022053-idft1p6d 124 19 of of IN cord-022053-idft1p6d 124 20 single single JJ cord-022053-idft1p6d 124 21 targets target NNS cord-022053-idft1p6d 124 22 , , , cord-022053-idft1p6d 124 23 and and CC cord-022053-idft1p6d 124 24 multiplexed multiplexed JJ cord-022053-idft1p6d 124 25 systems system NNS cord-022053-idft1p6d 124 26 that that WDT cord-022053-idft1p6d 124 27 allow allow VBP cord-022053-idft1p6d 124 28 for for IN cord-022053-idft1p6d 124 29 the the DT cord-022053-idft1p6d 124 30 detection detection NN cord-022053-idft1p6d 124 31 of of IN cord-022053-idft1p6d 124 32 many many JJ cord-022053-idft1p6d 124 33 organisms organism NNS cord-022053-idft1p6d 124 34 in in IN cord-022053-idft1p6d 124 35 one one CD cord-022053-idft1p6d 124 36 assay assay NN cord-022053-idft1p6d 124 37 . . . cord-022053-idft1p6d 125 1 Sequencing sequencing NN cord-022053-idft1p6d 125 2 assays assay NNS cord-022053-idft1p6d 125 3 are be VBP cord-022053-idft1p6d 125 4 becoming become VBG cord-022053-idft1p6d 125 5 more more RBR cord-022053-idft1p6d 125 6 commonplace commonplace JJ cord-022053-idft1p6d 125 7 , , , cord-022053-idft1p6d 125 8 with with IN cord-022053-idft1p6d 125 9 targets target NNS cord-022053-idft1p6d 125 10 ranging range VBG cord-022053-idft1p6d 125 11 from from IN cord-022053-idft1p6d 125 12 16S 16S NNP cord-022053-idft1p6d 125 13 rRNA rrna NN cord-022053-idft1p6d 125 14 to to IN cord-022053-idft1p6d 125 15 whole whole JJ cord-022053-idft1p6d 125 16 genomes genome NNS cord-022053-idft1p6d 125 17 and and CC cord-022053-idft1p6d 125 18 even even RB cord-022053-idft1p6d 125 19 metagenomic metagenomic JJ cord-022053-idft1p6d 125 20 studies study NNS cord-022053-idft1p6d 125 21 looking look VBG cord-022053-idft1p6d 125 22 at at IN cord-022053-idft1p6d 125 23 the the DT cord-022053-idft1p6d 125 24 make make NN cord-022053-idft1p6d 125 25 - - HYPH cord-022053-idft1p6d 125 26 up up NN cord-022053-idft1p6d 125 27 of of IN cord-022053-idft1p6d 125 28 complex complex JJ cord-022053-idft1p6d 125 29 microbial microbial JJ cord-022053-idft1p6d 125 30 ecosystems ecosystem NNS cord-022053-idft1p6d 125 31 within within IN cord-022053-idft1p6d 125 32 the the DT cord-022053-idft1p6d 125 33 human human JJ cord-022053-idft1p6d 125 34 host host NN cord-022053-idft1p6d 125 35 . . . cord-022053-idft1p6d 126 1 In in IN cord-022053-idft1p6d 126 2 this this DT cord-022053-idft1p6d 126 3 section section NN cord-022053-idft1p6d 126 4 the the DT cord-022053-idft1p6d 126 5 technologies technology NNS cord-022053-idft1p6d 126 6 behind behind IN cord-022053-idft1p6d 126 7 several several JJ cord-022053-idft1p6d 126 8 of of IN cord-022053-idft1p6d 126 9 the the DT cord-022053-idft1p6d 126 10 most most RBS cord-022053-idft1p6d 126 11 important important JJ cord-022053-idft1p6d 126 12 new new JJ cord-022053-idft1p6d 126 13 assays assay NNS cord-022053-idft1p6d 126 14 will will MD cord-022053-idft1p6d 126 15 be be VB cord-022053-idft1p6d 126 16 briefly briefly RB cord-022053-idft1p6d 126 17 introduced introduce VBN cord-022053-idft1p6d 126 18 , , , cord-022053-idft1p6d 126 19 followed follow VBN cord-022053-idft1p6d 126 20 by by IN cord-022053-idft1p6d 126 21 a a DT cord-022053-idft1p6d 126 22 discussion discussion NN cord-022053-idft1p6d 126 23 of of IN cord-022053-idft1p6d 126 24 their -PRON- PRP$ cord-022053-idft1p6d 126 25 application application NN cord-022053-idft1p6d 126 26 to to IN cord-022053-idft1p6d 126 27 clinical clinical JJ cord-022053-idft1p6d 126 28 syndromes syndrome NNS cord-022053-idft1p6d 126 29 , , , cord-022053-idft1p6d 126 30 such such JJ cord-022053-idft1p6d 126 31 as as IN cord-022053-idft1p6d 126 32 respiratory respiratory JJ cord-022053-idft1p6d 126 33 and and CC cord-022053-idft1p6d 126 34 gastrointestinal gastrointestinal JJ cord-022053-idft1p6d 126 35 ( ( -LRB- cord-022053-idft1p6d 126 36 GI GI NNP cord-022053-idft1p6d 126 37 ) ) -RRB- cord-022053-idft1p6d 126 38 disease disease NN cord-022053-idft1p6d 126 39 , , , cord-022053-idft1p6d 126 40 bloodstream bloodstream NN cord-022053-idft1p6d 126 41 infections infection NNS cord-022053-idft1p6d 126 42 , , , cord-022053-idft1p6d 126 43 meningitis meningitis NN cord-022053-idft1p6d 126 44 , , , cord-022053-idft1p6d 126 45 and and CC cord-022053-idft1p6d 126 46 reproductive reproductive JJ cord-022053-idft1p6d 126 47 health health NN cord-022053-idft1p6d 126 48 / / , cord-022053-idft1p6d 126 49 sexually sexually RB cord-022053-idft1p6d 126 50 transmitted transmit VBN cord-022053-idft1p6d 126 51 disease disease NN cord-022053-idft1p6d 126 52 . . . cord-022053-idft1p6d 127 1 Probe probe NN cord-022053-idft1p6d 127 2 hybridization hybridization NN cord-022053-idft1p6d 127 3 assays assay NNS cord-022053-idft1p6d 127 4 were be VBD cord-022053-idft1p6d 127 5 one one CD cord-022053-idft1p6d 127 6 of of IN cord-022053-idft1p6d 127 7 the the DT cord-022053-idft1p6d 127 8 earliest early JJS cord-022053-idft1p6d 127 9 diagnostic diagnostic JJ cord-022053-idft1p6d 127 10 techniques technique NNS cord-022053-idft1p6d 127 11 using use VBG cord-022053-idft1p6d 127 12 nucleic nucleic JJ cord-022053-idft1p6d 127 13 acids acid NNS cord-022053-idft1p6d 127 14 as as IN cord-022053-idft1p6d 127 15 a a DT cord-022053-idft1p6d 127 16 target target NN cord-022053-idft1p6d 127 17 . . . cord-022053-idft1p6d 128 1 The the DT cord-022053-idft1p6d 128 2 most most RBS cord-022053-idft1p6d 128 3 commonly commonly RB cord-022053-idft1p6d 128 4 used use VBN cord-022053-idft1p6d 128 5 probes probe NNS cord-022053-idft1p6d 128 6 are be VBP cord-022053-idft1p6d 128 7 marketed market VBN cord-022053-idft1p6d 128 8 by by IN cord-022053-idft1p6d 128 9 Hologic Hologic NNP cord-022053-idft1p6d 128 10 Gen Gen NNP cord-022053-idft1p6d 128 11 - - HYPH cord-022053-idft1p6d 128 12 Probe Probe NNP cord-022053-idft1p6d 128 13 Inc. Inc. NNP cord-022053-idft1p6d 128 14 ( ( -LRB- cord-022053-idft1p6d 128 15 Marlborough Marlborough NNP cord-022053-idft1p6d 128 16 , , , cord-022053-idft1p6d 128 17 extraction extraction NN cord-022053-idft1p6d 128 18 method method NN cord-022053-idft1p6d 128 19 and and CC cord-022053-idft1p6d 128 20 lowered lower VBD cord-022053-idft1p6d 128 21 identity identity NN cord-022053-idft1p6d 128 22 cutoffs cutoff NNS cord-022053-idft1p6d 128 23 ( ( -LRB- cord-022053-idft1p6d 128 24 i.e. i.e. FW cord-022053-idft1p6d 128 25 , , , cord-022053-idft1p6d 128 26 1.7 1.7 CD cord-022053-idft1p6d 128 27 on on IN cord-022053-idft1p6d 128 28 the the DT cord-022053-idft1p6d 128 29 Biotyper Biotyper NNP cord-022053-idft1p6d 128 30 ) ) -RRB- cord-022053-idft1p6d 128 31 are be VBP cord-022053-idft1p6d 128 32 optimal optimal JJ cord-022053-idft1p6d 128 33 for for IN cord-022053-idft1p6d 128 34 the the DT cord-022053-idft1p6d 128 35 analysis analysis NN cord-022053-idft1p6d 128 36 of of IN cord-022053-idft1p6d 128 37 yeasts yeast NNS cord-022053-idft1p6d 128 38 . . . cord-022053-idft1p6d 129 1 22 22 CD cord-022053-idft1p6d 130 1 Although although IN cord-022053-idft1p6d 130 2 not not RB cord-022053-idft1p6d 130 3 an an DT cord-022053-idft1p6d 130 4 FDA FDA NNP cord-022053-idft1p6d 130 5 - - HYPH cord-022053-idft1p6d 130 6 approved approve VBN cord-022053-idft1p6d 130 7 application application NN cord-022053-idft1p6d 130 8 , , , cord-022053-idft1p6d 130 9 MALDI MALDI NNP cord-022053-idft1p6d 130 10 has have VBZ cord-022053-idft1p6d 130 11 tremendous tremendous JJ cord-022053-idft1p6d 130 12 promise promise NN cord-022053-idft1p6d 130 13 for for IN cord-022053-idft1p6d 130 14 the the DT cord-022053-idft1p6d 130 15 identification identification NN cord-022053-idft1p6d 130 16 of of IN cord-022053-idft1p6d 130 17 mycobacteria mycobacterium NNS cord-022053-idft1p6d 130 18 and and CC cord-022053-idft1p6d 130 19 is be VBZ cord-022053-idft1p6d 130 20 already already RB cord-022053-idft1p6d 130 21 the the DT cord-022053-idft1p6d 130 22 preferred preferred JJ cord-022053-idft1p6d 130 23 identification identification NN cord-022053-idft1p6d 130 24 method method NN cord-022053-idft1p6d 130 25 of of IN cord-022053-idft1p6d 130 26 choice choice NN cord-022053-idft1p6d 130 27 for for IN cord-022053-idft1p6d 130 28 these these DT cord-022053-idft1p6d 130 29 organisms organism NNS cord-022053-idft1p6d 130 30 in in IN cord-022053-idft1p6d 130 31 some some DT cord-022053-idft1p6d 130 32 clinical clinical JJ cord-022053-idft1p6d 130 33 laboratories laboratory NNS cord-022053-idft1p6d 130 34 . . . cord-022053-idft1p6d 131 1 5 5 LS cord-022053-idft1p6d 132 1 Caveats caveat NNS cord-022053-idft1p6d 132 2 include include VBP cord-022053-idft1p6d 132 3 the the DT cord-022053-idft1p6d 132 4 need need NN cord-022053-idft1p6d 132 5 for for IN cord-022053-idft1p6d 132 6 enhanced enhance VBN cord-022053-idft1p6d 132 7 sample sample NN cord-022053-idft1p6d 132 8 preparation preparation NN cord-022053-idft1p6d 132 9 methods method NNS cord-022053-idft1p6d 132 10 for for IN cord-022053-idft1p6d 132 11 efficient efficient JJ cord-022053-idft1p6d 132 12 cell cell NN cord-022053-idft1p6d 132 13 breakage breakage NN cord-022053-idft1p6d 132 14 for for IN cord-022053-idft1p6d 132 15 biosafety biosafety NN cord-022053-idft1p6d 132 16 reasons reason NNS cord-022053-idft1p6d 132 17 and and CC cord-022053-idft1p6d 132 18 to to TO cord-022053-idft1p6d 132 19 ensure ensure VB cord-022053-idft1p6d 132 20 high high JJ cord-022053-idft1p6d 132 21 - - HYPH cord-022053-idft1p6d 132 22 quality quality NN cord-022053-idft1p6d 132 23 spectra spectrum NNS cord-022053-idft1p6d 132 24 . . . cord-022053-idft1p6d 133 1 3 3 CD cord-022053-idft1p6d 133 2 , , , cord-022053-idft1p6d 133 3 23 23 CD cord-022053-idft1p6d 133 4 , , , cord-022053-idft1p6d 133 5 24 24 CD cord-022053-idft1p6d 133 6 Several several JJ cord-022053-idft1p6d 133 7 studies study NNS cord-022053-idft1p6d 133 8 have have VBP cord-022053-idft1p6d 133 9 shown show VBN cord-022053-idft1p6d 133 10 promising promising JJ cord-022053-idft1p6d 133 11 results result NNS cord-022053-idft1p6d 133 12 . . . cord-022053-idft1p6d 134 1 Using use VBG cord-022053-idft1p6d 134 2 the the DT cord-022053-idft1p6d 134 3 Biotyper Biotyper NNP cord-022053-idft1p6d 134 4 equipped equip VBN cord-022053-idft1p6d 134 5 with with IN cord-022053-idft1p6d 134 6 the the DT cord-022053-idft1p6d 134 7 mycobacterial mycobacterial NNP cord-022053-idft1p6d 134 8 library library NNP cord-022053-idft1p6d 134 9 version version NN cord-022053-idft1p6d 134 10 1.0 1.0 CD cord-022053-idft1p6d 134 11 and and CC cord-022053-idft1p6d 134 12 the the DT cord-022053-idft1p6d 134 13 Vitek Vitek NNP cord-022053-idft1p6d 134 14 MS MS NNP cord-022053-idft1p6d 134 15 , , , cord-022053-idft1p6d 134 16 84.7 84.7 CD cord-022053-idft1p6d 134 17 % % NN cord-022053-idft1p6d 134 18 to to IN cord-022053-idft1p6d 134 19 93.8 93.8 CD cord-022053-idft1p6d 134 20 % % NN cord-022053-idft1p6d 134 21 of of IN cord-022053-idft1p6d 134 22 isolates isolate NNS cord-022053-idft1p6d 134 23 were be VBD cord-022053-idft1p6d 134 24 identified identify VBN cord-022053-idft1p6d 134 25 correctly correctly RB cord-022053-idft1p6d 134 26 to to IN cord-022053-idft1p6d 134 27 the the DT cord-022053-idft1p6d 134 28 species species NN cord-022053-idft1p6d 134 29 level level NN cord-022053-idft1p6d 134 30 . . . cord-022053-idft1p6d 135 1 24 24 CD cord-022053-idft1p6d 135 2 , , , cord-022053-idft1p6d 135 3 25 25 CD cord-022053-idft1p6d 135 4 Bruker Bruker NNP cord-022053-idft1p6d 135 5 has have VBZ cord-022053-idft1p6d 135 6 subsequently subsequently RB cord-022053-idft1p6d 135 7 released release VBN cord-022053-idft1p6d 135 8 a a DT cord-022053-idft1p6d 135 9 new new JJ cord-022053-idft1p6d 135 10 version version NN cord-022053-idft1p6d 135 11 of of IN cord-022053-idft1p6d 135 12 the the DT cord-022053-idft1p6d 135 13 mycobacterial mycobacterial NNP cord-022053-idft1p6d 135 14 library library NNP cord-022053-idft1p6d 135 15 , , , cord-022053-idft1p6d 135 16 version version NN cord-022053-idft1p6d 135 17 3.0 3.0 CD cord-022053-idft1p6d 135 18 , , , cord-022053-idft1p6d 135 19 containing contain VBG cord-022053-idft1p6d 135 20 149 149 CD cord-022053-idft1p6d 135 21 different different JJ cord-022053-idft1p6d 135 22 species specie NNS cord-022053-idft1p6d 135 23 . . . cord-022053-idft1p6d 136 1 It -PRON- PRP cord-022053-idft1p6d 136 2 reportedly reportedly RB cord-022053-idft1p6d 136 3 demonstrated demonstrate VBD cord-022053-idft1p6d 136 4 high high JJ cord-022053-idft1p6d 136 5 performance performance NN cord-022053-idft1p6d 136 6 ( ( -LRB- cord-022053-idft1p6d 136 7 > > NFP cord-022053-idft1p6d 136 8 95 95 CD cord-022053-idft1p6d 136 9 % % NN cord-022053-idft1p6d 136 10 correct correct JJ cord-022053-idft1p6d 136 11 identification identification NN cord-022053-idft1p6d 136 12 to to IN cord-022053-idft1p6d 136 13 species species NN cord-022053-idft1p6d 136 14 level level NN cord-022053-idft1p6d 136 15 ) ) -RRB- cord-022053-idft1p6d 136 16 in in IN cord-022053-idft1p6d 136 17 a a DT cord-022053-idft1p6d 136 18 group group NN cord-022053-idft1p6d 136 19 of of IN cord-022053-idft1p6d 136 20 1045 1045 CD cord-022053-idft1p6d 136 21 clinical clinical JJ cord-022053-idft1p6d 136 22 samples sample NNS cord-022053-idft1p6d 136 23 . . . cord-022053-idft1p6d 137 1 26 26 CD cord-022053-idft1p6d 137 2 Version version NN cord-022053-idft1p6d 137 3 3.0 3.0 CD cord-022053-idft1p6d 137 4 of of IN cord-022053-idft1p6d 137 5 the the DT cord-022053-idft1p6d 137 6 Biotyper Biotyper NNP cord-022053-idft1p6d 137 7 mycobacterial mycobacterial NNP cord-022053-idft1p6d 137 8 library library NN cord-022053-idft1p6d 137 9 was be VBD cord-022053-idft1p6d 137 10 also also RB cord-022053-idft1p6d 137 11 described describe VBN cord-022053-idft1p6d 137 12 by by IN cord-022053-idft1p6d 137 13 Rodriguez Rodriguez NNP cord-022053-idft1p6d 137 14 - - HYPH cord-022053-idft1p6d 137 15 Sanchez Sanchez NNP cord-022053-idft1p6d 137 16 et et NNP cord-022053-idft1p6d 137 17 al al NNP cord-022053-idft1p6d 137 18 . . NNP cord-022053-idft1p6d 137 19 , , , cord-022053-idft1p6d 137 20 who who WP cord-022053-idft1p6d 137 21 found find VBD cord-022053-idft1p6d 137 22 91.7 91.7 CD cord-022053-idft1p6d 137 23 % % NN cord-022053-idft1p6d 137 24 identification identification NN cord-022053-idft1p6d 137 25 to to IN cord-022053-idft1p6d 137 26 species species NN cord-022053-idft1p6d 137 27 level level NN cord-022053-idft1p6d 137 28 on on IN cord-022053-idft1p6d 137 29 a a DT cord-022053-idft1p6d 137 30 group group NN cord-022053-idft1p6d 137 31 of of IN cord-022053-idft1p6d 137 32 109 109 CD cord-022053-idft1p6d 137 33 non non JJ cord-022053-idft1p6d 137 34 - - JJ cord-022053-idft1p6d 137 35 tuberculosis tuberculosis JJ cord-022053-idft1p6d 137 36 mycobacteria mycobacterium NNS cord-022053-idft1p6d 137 37 . . . cord-022053-idft1p6d 138 1 27 27 CD cord-022053-idft1p6d 139 1 There there EX cord-022053-idft1p6d 139 2 is be VBZ cord-022053-idft1p6d 139 3 a a DT cord-022053-idft1p6d 139 4 great great JJ cord-022053-idft1p6d 139 5 deal deal NN cord-022053-idft1p6d 139 6 of of IN cord-022053-idft1p6d 139 7 interest interest NN cord-022053-idft1p6d 139 8 in in IN cord-022053-idft1p6d 139 9 the the DT cord-022053-idft1p6d 139 10 identification identification NN cord-022053-idft1p6d 139 11 of of IN cord-022053-idft1p6d 139 12 fungi fungus NNS cord-022053-idft1p6d 139 13 other other JJ cord-022053-idft1p6d 139 14 than than IN cord-022053-idft1p6d 139 15 yeast yeast NN cord-022053-idft1p6d 139 16 by by IN cord-022053-idft1p6d 139 17 MALDI MALDI NNS cord-022053-idft1p6d 139 18 , , , cord-022053-idft1p6d 139 19 also also RB cord-022053-idft1p6d 139 20 not not RB cord-022053-idft1p6d 139 21 an an DT cord-022053-idft1p6d 139 22 FDA FDA NNP cord-022053-idft1p6d 139 23 - - HYPH cord-022053-idft1p6d 139 24 approved approve VBN cord-022053-idft1p6d 139 25 application application NN cord-022053-idft1p6d 139 26 . . . cord-022053-idft1p6d 140 1 Concerns concern NNS cord-022053-idft1p6d 140 2 with with IN cord-022053-idft1p6d 140 3 this this DT cord-022053-idft1p6d 140 4 group group NN cord-022053-idft1p6d 140 5 include include VBP cord-022053-idft1p6d 140 6 not not RB cord-022053-idft1p6d 140 7 only only RB cord-022053-idft1p6d 140 8 efficient efficient JJ cord-022053-idft1p6d 140 9 cell cell NN cord-022053-idft1p6d 140 10 lysis lysis NN cord-022053-idft1p6d 140 11 but but CC cord-022053-idft1p6d 140 12 also also RB cord-022053-idft1p6d 140 13 the the DT cord-022053-idft1p6d 140 14 need need NN cord-022053-idft1p6d 140 15 for for IN cord-022053-idft1p6d 140 16 higher high JJR cord-022053-idft1p6d 140 17 - - HYPH cord-022053-idft1p6d 140 18 quality quality NN cord-022053-idft1p6d 140 19 reference reference NN cord-022053-idft1p6d 140 20 databases database NNS cord-022053-idft1p6d 140 21 . . . cord-022053-idft1p6d 141 1 17 17 CD cord-022053-idft1p6d 142 1 Few few JJ cord-022053-idft1p6d 142 2 studies study NNS cord-022053-idft1p6d 142 3 have have VBP cord-022053-idft1p6d 142 4 assessed assess VBN cord-022053-idft1p6d 142 5 the the DT cord-022053-idft1p6d 142 6 Biotyper Biotyper NNP cord-022053-idft1p6d 142 7 or or CC cord-022053-idft1p6d 142 8 Vitek Vitek NNP cord-022053-idft1p6d 142 9 MS MS NNP cord-022053-idft1p6d 142 10 platforms platform NNS cord-022053-idft1p6d 142 11 on on IN cord-022053-idft1p6d 142 12 fungal fungal JJ cord-022053-idft1p6d 142 13 isolates isolate NNS cord-022053-idft1p6d 142 14 using use VBG cord-022053-idft1p6d 142 15 only only RB cord-022053-idft1p6d 142 16 the the DT cord-022053-idft1p6d 142 17 commercially commercially RB cord-022053-idft1p6d 142 18 available available JJ cord-022053-idft1p6d 142 19 databases database NNS cord-022053-idft1p6d 142 20 . . . cord-022053-idft1p6d 143 1 Iriart Iriart NNP cord-022053-idft1p6d 143 2 et et NNP cord-022053-idft1p6d 143 3 al al NNP cord-022053-idft1p6d 143 4 . . . cord-022053-idft1p6d 143 5 analyzed analyze VBD cord-022053-idft1p6d 143 6 a a DT cord-022053-idft1p6d 143 7 group group NN cord-022053-idft1p6d 143 8 of of IN cord-022053-idft1p6d 143 9 236 236 CD cord-022053-idft1p6d 143 10 clinical clinical JJ cord-022053-idft1p6d 143 11 isolates isolate NNS cord-022053-idft1p6d 143 12 with with IN cord-022053-idft1p6d 143 13 the the DT cord-022053-idft1p6d 143 14 Vitek Vitek NNP cord-022053-idft1p6d 143 15 MS MS NNP cord-022053-idft1p6d 143 16 ( ( -LRB- cord-022053-idft1p6d 143 17 192 192 CD cord-022053-idft1p6d 143 18 yeast yeast NN cord-022053-idft1p6d 143 19 and and CC cord-022053-idft1p6d 143 20 44 44 CD cord-022053-idft1p6d 143 21 Aspergillus aspergillus NN cord-022053-idft1p6d 143 22 ) ) -RRB- cord-022053-idft1p6d 143 23 and and CC cord-022053-idft1p6d 143 24 found find VBD cord-022053-idft1p6d 143 25 that that IN cord-022053-idft1p6d 143 26 93.2 93.2 CD cord-022053-idft1p6d 143 27 % % NN cord-022053-idft1p6d 143 28 of of IN cord-022053-idft1p6d 143 29 the the DT cord-022053-idft1p6d 143 30 isolates isolate NNS cord-022053-idft1p6d 143 31 were be VBD cord-022053-idft1p6d 143 32 correctly correctly RB cord-022053-idft1p6d 143 33 identified identify VBN cord-022053-idft1p6d 143 34 , , , cord-022053-idft1p6d 143 35 including include VBG cord-022053-idft1p6d 143 36 81.8 81.8 CD cord-022053-idft1p6d 143 37 % % NN cord-022053-idft1p6d 143 38 of of IN cord-022053-idft1p6d 143 39 the the DT cord-022053-idft1p6d 143 40 Aspergillus aspergillus NN cord-022053-idft1p6d 143 41 . . . cord-022053-idft1p6d 144 1 28 28 CD cord-022053-idft1p6d 145 1 This this DT cord-022053-idft1p6d 145 2 compared compare VBN cord-022053-idft1p6d 145 3 with with IN cord-022053-idft1p6d 145 4 94.1 94.1 CD cord-022053-idft1p6d 145 5 % % NN cord-022053-idft1p6d 145 6 and and CC cord-022053-idft1p6d 145 7 88.6 88.6 CD cord-022053-idft1p6d 145 8 % % NN cord-022053-idft1p6d 145 9 , , , cord-022053-idft1p6d 145 10 respectively respectively RB cord-022053-idft1p6d 145 11 , , , cord-022053-idft1p6d 145 12 by by IN cord-022053-idft1p6d 145 13 routine routine JJ cord-022053-idft1p6d 145 14 laboratory laboratory NN cord-022053-idft1p6d 145 15 methods method NNS cord-022053-idft1p6d 145 16 . . . cord-022053-idft1p6d 146 1 When when WRB cord-022053-idft1p6d 146 2 the the DT cord-022053-idft1p6d 146 3 authors author NNS cord-022053-idft1p6d 146 4 limited limit VBD cord-022053-idft1p6d 146 5 the the DT cord-022053-idft1p6d 146 6 study study NN cord-022053-idft1p6d 146 7 to to IN cord-022053-idft1p6d 146 8 only only RB cord-022053-idft1p6d 146 9 those those DT cord-022053-idft1p6d 146 10 species specie NNS cord-022053-idft1p6d 146 11 that that WDT cord-022053-idft1p6d 146 12 were be VBD cord-022053-idft1p6d 146 13 present present JJ cord-022053-idft1p6d 146 14 in in IN cord-022053-idft1p6d 146 15 the the DT cord-022053-idft1p6d 146 16 database database NN cord-022053-idft1p6d 146 17 , , , cord-022053-idft1p6d 146 18 100 100 CD cord-022053-idft1p6d 146 19 % % NN cord-022053-idft1p6d 146 20 of of IN cord-022053-idft1p6d 146 21 the the DT cord-022053-idft1p6d 146 22 Aspergillus aspergillus NN cord-022053-idft1p6d 146 23 isolates isolate NNS cord-022053-idft1p6d 146 24 were be VBD cord-022053-idft1p6d 146 25 correctly correctly RB cord-022053-idft1p6d 146 26 identified identify VBN cord-022053-idft1p6d 146 27 . . . cord-022053-idft1p6d 147 1 28 28 CD cord-022053-idft1p6d 148 1 In in IN cord-022053-idft1p6d 148 2 another another DT cord-022053-idft1p6d 148 3 study study NN cord-022053-idft1p6d 148 4 the the DT cord-022053-idft1p6d 148 5 Vitek Vitek NNP cord-022053-idft1p6d 148 6 MS MS NNP cord-022053-idft1p6d 148 7 was be VBD cord-022053-idft1p6d 148 8 able able JJ cord-022053-idft1p6d 148 9 to to TO cord-022053-idft1p6d 148 10 correctly correctly RB cord-022053-idft1p6d 148 11 discriminate discriminate VB cord-022053-idft1p6d 148 12 closely closely RB cord-022053-idft1p6d 148 13 related related JJ cord-022053-idft1p6d 148 14 Aspergillus aspergillus NN cord-022053-idft1p6d 148 15 species specie NNS cord-022053-idft1p6d 148 16 , , , cord-022053-idft1p6d 148 17 Aspergillus aspergillus NN cord-022053-idft1p6d 148 18 fumigatus fumigatus NN cord-022053-idft1p6d 148 19 and and CC cord-022053-idft1p6d 148 20 Aspergillus aspergillus NN cord-022053-idft1p6d 148 21 lentulus lentulus NN cord-022053-idft1p6d 148 22 . . . cord-022053-idft1p6d 149 1 29 29 CD cord-022053-idft1p6d 150 1 Schulthess Schulthess NNP cord-022053-idft1p6d 150 2 et et NNP cord-022053-idft1p6d 150 3 al al NNP cord-022053-idft1p6d 150 4 . . . cord-022053-idft1p6d 151 1 did do VBD cord-022053-idft1p6d 151 2 a a DT cord-022053-idft1p6d 151 3 prospective prospective JJ cord-022053-idft1p6d 151 4 study study NN cord-022053-idft1p6d 151 5 on on IN cord-022053-idft1p6d 151 6 200 200 CD cord-022053-idft1p6d 151 7 isolates isolate NNS cord-022053-idft1p6d 151 8 using use VBG cord-022053-idft1p6d 151 9 the the DT cord-022053-idft1p6d 151 10 Biotyper Biotyper NNP cord-022053-idft1p6d 151 11 / / SYM cord-022053-idft1p6d 151 12 Filamentous Filamentous NNP cord-022053-idft1p6d 151 13 Fungi Fungi NNP cord-022053-idft1p6d 151 14 Library Library NNP cord-022053-idft1p6d 151 15 1.0 1.0 CD cord-022053-idft1p6d 151 16 . . . cord-022053-idft1p6d 152 1 They -PRON- PRP cord-022053-idft1p6d 152 2 achieved achieve VBD cord-022053-idft1p6d 152 3 a a DT cord-022053-idft1p6d 152 4 79 79 CD cord-022053-idft1p6d 152 5 % % NN cord-022053-idft1p6d 152 6 species specie NNS cord-022053-idft1p6d 152 7 and and CC cord-022053-idft1p6d 152 8 83.5 83.5 CD cord-022053-idft1p6d 152 9 % % NN cord-022053-idft1p6d 152 10 genus genus NN cord-022053-idft1p6d 152 11 level level NN cord-022053-idft1p6d 152 12 identification identification NN cord-022053-idft1p6d 152 13 . . . cord-022053-idft1p6d 153 1 Particularly particularly RB cord-022053-idft1p6d 153 2 poor poor JJ cord-022053-idft1p6d 153 3 performance performance NN cord-022053-idft1p6d 153 4 was be VBD cord-022053-idft1p6d 153 5 noted note VBN cord-022053-idft1p6d 153 6 for for IN cord-022053-idft1p6d 153 7 Mucor Mucor NNP cord-022053-idft1p6d 153 8 and and CC cord-022053-idft1p6d 153 9 Scopulariposis Scopulariposis NNP cord-022053-idft1p6d 153 10 . . . cord-022053-idft1p6d 154 1 30 30 CD cord-022053-idft1p6d 154 2 Chen Chen NNP cord-022053-idft1p6d 154 3 et et NNP cord-022053-idft1p6d 154 4 al al NNP cord-022053-idft1p6d 154 5 . . . cord-022053-idft1p6d 155 1 evaluated evaluate VBN cord-022053-idft1p6d 155 2 50 50 CD cord-022053-idft1p6d 155 3 clinical clinical JJ cord-022053-idft1p6d 155 4 mold mold NN cord-022053-idft1p6d 155 5 isolates isolate VBZ cord-022053-idft1p6d 155 6 with with IN cord-022053-idft1p6d 155 7 the the DT cord-022053-idft1p6d 155 8 Biotyper Biotyper NNP cord-022053-idft1p6d 155 9 and and CC cord-022053-idft1p6d 155 10 found find VBD cord-022053-idft1p6d 155 11 that that IN cord-022053-idft1p6d 155 12 several several JJ cord-022053-idft1p6d 155 13 were be VBD cord-022053-idft1p6d 155 14 not not RB cord-022053-idft1p6d 155 15 identified identify VBN cord-022053-idft1p6d 155 16 or or CC cord-022053-idft1p6d 155 17 identified identify VBN cord-022053-idft1p6d 155 18 with with IN cord-022053-idft1p6d 155 19 a a DT cord-022053-idft1p6d 155 20 low low JJ cord-022053-idft1p6d 155 21 score score NN cord-022053-idft1p6d 155 22 ( ( -LRB- cord-022053-idft1p6d 155 23 < < NNP cord-022053-idft1p6d 155 24 1.7 1.7 CD cord-022053-idft1p6d 155 25 ) ) -RRB- cord-022053-idft1p6d 155 26 . . . cord-022053-idft1p6d 156 1 31 31 CD cord-022053-idft1p6d 156 2 Twenty twenty CD cord-022053-idft1p6d 156 3 - - HYPH cord-022053-idft1p6d 156 4 eight eight CD cord-022053-idft1p6d 156 5 isolates isolate NNS cord-022053-idft1p6d 156 6 of of IN cord-022053-idft1p6d 156 7 Penicillium Penicillium NNP cord-022053-idft1p6d 156 8 marneffei marneffei NNP cord-022053-idft1p6d 156 9 were be VBD cord-022053-idft1p6d 156 10 not not RB cord-022053-idft1p6d 156 11 identified identify VBN cord-022053-idft1p6d 156 12 due due IN cord-022053-idft1p6d 156 13 to to IN cord-022053-idft1p6d 156 14 the the DT cord-022053-idft1p6d 156 15 lack lack NN cord-022053-idft1p6d 156 16 of of IN cord-022053-idft1p6d 156 17 reference reference NN cord-022053-idft1p6d 156 18 spectra spectrum NNS cord-022053-idft1p6d 156 19 in in IN cord-022053-idft1p6d 156 20 the the DT cord-022053-idft1p6d 156 21 database database NN cord-022053-idft1p6d 156 22 ; ; : cord-022053-idft1p6d 156 23 however however RB cord-022053-idft1p6d 156 24 , , , cord-022053-idft1p6d 156 25 the the DT cord-022053-idft1p6d 156 26 rate rate NN cord-022053-idft1p6d 156 27 of of IN cord-022053-idft1p6d 156 28 identification identification NN cord-022053-idft1p6d 156 29 went go VBD cord-022053-idft1p6d 156 30 up up IN cord-022053-idft1p6d 156 31 to to IN cord-022053-idft1p6d 156 32 85.7 85.7 CD cord-022053-idft1p6d 156 33 % % NN cord-022053-idft1p6d 156 34 after after IN cord-022053-idft1p6d 156 35 a a DT cord-022053-idft1p6d 156 36 single single JJ cord-022053-idft1p6d 156 37 P. P. NNP cord-022053-idft1p6d 156 38 marneffei marneffei NNP cord-022053-idft1p6d 156 39 spectrum spectrum NN cord-022053-idft1p6d 156 40 was be VBD cord-022053-idft1p6d 156 41 added add VBN cord-022053-idft1p6d 156 42 to to IN cord-022053-idft1p6d 156 43 the the DT cord-022053-idft1p6d 156 44 database database NN cord-022053-idft1p6d 156 45 . . . cord-022053-idft1p6d 157 1 This this DT cord-022053-idft1p6d 157 2 result result NN cord-022053-idft1p6d 157 3 is be VBZ cord-022053-idft1p6d 157 4 consistent consistent JJ cord-022053-idft1p6d 157 5 with with IN cord-022053-idft1p6d 157 6 a a DT cord-022053-idft1p6d 157 7 number number NN cord-022053-idft1p6d 157 8 of of IN cord-022053-idft1p6d 157 9 studies study NNS cord-022053-idft1p6d 157 10 indicating indicate VBG cord-022053-idft1p6d 157 11 high high JJ cord-022053-idft1p6d 157 12 performance performance NN cord-022053-idft1p6d 157 13 of of IN cord-022053-idft1p6d 157 14 MALDI MALDI NNS cord-022053-idft1p6d 157 15 on on IN cord-022053-idft1p6d 157 16 fungal fungal NN cord-022053-idft1p6d 157 17 isolates isolate NNS cord-022053-idft1p6d 157 18 using use VBG cord-022053-idft1p6d 157 19 custom custom NN cord-022053-idft1p6d 157 20 databases database NNS cord-022053-idft1p6d 157 21 . . . cord-022053-idft1p6d 158 1 [ [ -LRB- cord-022053-idft1p6d 158 2 32 32 CD cord-022053-idft1p6d 158 3 ] ] -RRB- cord-022053-idft1p6d 158 4 [ [ -LRB- cord-022053-idft1p6d 158 5 33 33 CD cord-022053-idft1p6d 158 6 ] ] -RRB- cord-022053-idft1p6d 159 1 [ [ -LRB- cord-022053-idft1p6d 159 2 34 34 CD cord-022053-idft1p6d 159 3 ] ] -RRB- cord-022053-idft1p6d 159 4 [ [ -LRB- cord-022053-idft1p6d 159 5 35 35 CD cord-022053-idft1p6d 159 6 ] ] -RRB- cord-022053-idft1p6d 159 7 [ [ -LRB- cord-022053-idft1p6d 159 8 36 36 CD cord-022053-idft1p6d 159 9 ] ] -RRB- cord-022053-idft1p6d 160 1 [ [ -LRB- cord-022053-idft1p6d 160 2 37 37 CD cord-022053-idft1p6d 160 3 ] ] -RRB- cord-022053-idft1p6d 161 1 Although although IN cord-022053-idft1p6d 161 2 the the DT cord-022053-idft1p6d 161 3 use use NN cord-022053-idft1p6d 161 4 of of IN cord-022053-idft1p6d 161 5 MALDI MALDI NNP cord-022053-idft1p6d 161 6 - - HYPH cord-022053-idft1p6d 161 7 TOF TOF NNP cord-022053-idft1p6d 161 8 in in IN cord-022053-idft1p6d 161 9 the the DT cord-022053-idft1p6d 161 10 microbiology microbiology NN cord-022053-idft1p6d 161 11 lab lab NN cord-022053-idft1p6d 161 12 has have VBZ cord-022053-idft1p6d 161 13 been be VBN cord-022053-idft1p6d 161 14 confined confine VBN cord-022053-idft1p6d 161 15 , , , cord-022053-idft1p6d 161 16 for for IN cord-022053-idft1p6d 161 17 the the DT cord-022053-idft1p6d 161 18 most most JJS cord-022053-idft1p6d 161 19 part part NN cord-022053-idft1p6d 161 20 , , , cord-022053-idft1p6d 161 21 to to IN cord-022053-idft1p6d 161 22 cultured cultured JJ cord-022053-idft1p6d 161 23 organisms organism NNS cord-022053-idft1p6d 161 24 , , , cord-022053-idft1p6d 161 25 there there EX cord-022053-idft1p6d 161 26 have have VBP cord-022053-idft1p6d 161 27 been be VBN cord-022053-idft1p6d 161 28 several several JJ cord-022053-idft1p6d 161 29 studies study NNS cord-022053-idft1p6d 161 30 exploring explore VBG cord-022053-idft1p6d 161 31 the the DT cord-022053-idft1p6d 161 32 feasibility feasibility NN cord-022053-idft1p6d 161 33 of of IN cord-022053-idft1p6d 161 34 its -PRON- PRP$ cord-022053-idft1p6d 161 35 use use NN cord-022053-idft1p6d 161 36 in in IN cord-022053-idft1p6d 161 37 primary primary JJ cord-022053-idft1p6d 161 38 samples sample NNS cord-022053-idft1p6d 161 39 . . . cord-022053-idft1p6d 162 1 For for IN cord-022053-idft1p6d 162 2 example example NN cord-022053-idft1p6d 162 3 , , , cord-022053-idft1p6d 162 4 the the DT cord-022053-idft1p6d 162 5 use use NN cord-022053-idft1p6d 162 6 of of IN cord-022053-idft1p6d 162 7 MALDI MALDI NNS cord-022053-idft1p6d 162 8 directly directly RB cord-022053-idft1p6d 162 9 on on IN cord-022053-idft1p6d 162 10 positive positive JJ cord-022053-idft1p6d 162 11 blood blood NN cord-022053-idft1p6d 162 12 cultures culture NNS cord-022053-idft1p6d 162 13 is be VBZ cord-022053-idft1p6d 162 14 attractive attractive JJ cord-022053-idft1p6d 162 15 for for IN cord-022053-idft1p6d 162 16 both both CC cord-022053-idft1p6d 162 17 its -PRON- PRP$ cord-022053-idft1p6d 162 18 rapidity rapidity NN cord-022053-idft1p6d 162 19 and and CC cord-022053-idft1p6d 162 20 the the DT cord-022053-idft1p6d 162 21 breadth breadth NN cord-022053-idft1p6d 162 22 of of IN cord-022053-idft1p6d 162 23 detection detection NN cord-022053-idft1p6d 162 24 possible possible JJ cord-022053-idft1p6d 162 25 with with IN cord-022053-idft1p6d 162 26 an an DT cord-022053-idft1p6d 162 27 open open JJ cord-022053-idft1p6d 162 28 system system NN cord-022053-idft1p6d 162 29 . . . cord-022053-idft1p6d 163 1 Sample sample NN cord-022053-idft1p6d 163 2 processing processing NN cord-022053-idft1p6d 163 3 directly directly RB cord-022053-idft1p6d 163 4 from from IN cord-022053-idft1p6d 163 5 blood blood NN cord-022053-idft1p6d 163 6 is be VBZ cord-022053-idft1p6d 163 7 not not RB cord-022053-idft1p6d 163 8 trivial trivial JJ cord-022053-idft1p6d 163 9 and and CC cord-022053-idft1p6d 163 10 not not RB cord-022053-idft1p6d 163 11 yet yet RB cord-022053-idft1p6d 163 12 FDA FDA NNP cord-022053-idft1p6d 163 13 approved approve VBD cord-022053-idft1p6d 163 14 , , , cord-022053-idft1p6d 163 15 but but CC cord-022053-idft1p6d 163 16 each each DT cord-022053-idft1p6d 163 17 major major JJ cord-022053-idft1p6d 163 18 platform platform NN cord-022053-idft1p6d 163 19 has have VBZ cord-022053-idft1p6d 163 20 a a DT cord-022053-idft1p6d 163 21 dedicated dedicated JJ cord-022053-idft1p6d 163 22 process process NN cord-022053-idft1p6d 163 23 and and CC cord-022053-idft1p6d 163 24 the the DT cord-022053-idft1p6d 163 25 results result NNS cord-022053-idft1p6d 163 26 are be VBP cord-022053-idft1p6d 163 27 promising promise VBG cord-022053-idft1p6d 163 28 with with IN cord-022053-idft1p6d 163 29 high high JJ cord-022053-idft1p6d 163 30 clinical clinical JJ cord-022053-idft1p6d 163 31 accuracy accuracy NN cord-022053-idft1p6d 163 32 ( ( -LRB- cord-022053-idft1p6d 163 33 80 80 CD cord-022053-idft1p6d 163 34 % % NN cord-022053-idft1p6d 163 35 to to TO cord-022053-idft1p6d 163 36 90 90 CD cord-022053-idft1p6d 163 37 % % NN cord-022053-idft1p6d 163 38 ) ) -RRB- cord-022053-idft1p6d 163 39 . . . cord-022053-idft1p6d 164 1 3 3 CD cord-022053-idft1p6d 164 2 , , , cord-022053-idft1p6d 164 3 38 38 CD cord-022053-idft1p6d 164 4 , , , cord-022053-idft1p6d 164 5 39 39 CD cord-022053-idft1p6d 164 6 Other other JJ cord-022053-idft1p6d 164 7 promising promising JJ cord-022053-idft1p6d 164 8 applications application NNS cord-022053-idft1p6d 164 9 include include VBP cord-022053-idft1p6d 164 10 direct direct JJ cord-022053-idft1p6d 164 11 analysis analysis NN cord-022053-idft1p6d 164 12 of of IN cord-022053-idft1p6d 164 13 urine urine NN cord-022053-idft1p6d 164 14 and and CC cord-022053-idft1p6d 164 15 cerebrospinal cerebrospinal NN cord-022053-idft1p6d 164 16 fluid fluid NN cord-022053-idft1p6d 164 17 ( ( -LRB- cord-022053-idft1p6d 164 18 CSF CSF NNP cord-022053-idft1p6d 164 19 ) ) -RRB- cord-022053-idft1p6d 164 20 , , , cord-022053-idft1p6d 164 21 although although IN cord-022053-idft1p6d 164 22 , , , cord-022053-idft1p6d 164 23 as as IN cord-022053-idft1p6d 164 24 with with IN cord-022053-idft1p6d 164 25 blood blood NN cord-022053-idft1p6d 164 26 , , , cord-022053-idft1p6d 164 27 additional additional JJ cord-022053-idft1p6d 164 28 screening screening NN cord-022053-idft1p6d 164 29 and and CC cord-022053-idft1p6d 164 30 processing processing NN cord-022053-idft1p6d 164 31 steps step NNS cord-022053-idft1p6d 164 32 are be VBP cord-022053-idft1p6d 164 33 required require VBN cord-022053-idft1p6d 164 34 . . . cord-022053-idft1p6d 165 1 3 3 LS cord-022053-idft1p6d 165 2 , , , cord-022053-idft1p6d 165 3 [ [ -LRB- cord-022053-idft1p6d 165 4 40 40 CD cord-022053-idft1p6d 165 5 ] ] -RRB- cord-022053-idft1p6d 165 6 [ [ -LRB- cord-022053-idft1p6d 165 7 41 41 CD cord-022053-idft1p6d 165 8 ] ] -RRB- cord-022053-idft1p6d 166 1 [ [ -LRB- cord-022053-idft1p6d 166 2 42 42 CD cord-022053-idft1p6d 166 3 ] ] -RRB- cord-022053-idft1p6d 166 4 [ [ -LRB- cord-022053-idft1p6d 166 5 43 43 CD cord-022053-idft1p6d 166 6 ] ] -RRB- cord-022053-idft1p6d 167 1 In in IN cord-022053-idft1p6d 167 2 summary summary NN cord-022053-idft1p6d 167 3 , , , cord-022053-idft1p6d 167 4 MALDI MALDI NNP cord-022053-idft1p6d 167 5 - - HYPH cord-022053-idft1p6d 167 6 TOF TOF NNP cord-022053-idft1p6d 167 7 in in IN cord-022053-idft1p6d 167 8 the the DT cord-022053-idft1p6d 167 9 clinical clinical JJ cord-022053-idft1p6d 167 10 microbiology microbiology NN cord-022053-idft1p6d 167 11 lab lab NN cord-022053-idft1p6d 167 12 has have VBZ cord-022053-idft1p6d 167 13 been be VBN cord-022053-idft1p6d 167 14 developed develop VBN cord-022053-idft1p6d 167 15 to to TO cord-022053-idft1p6d 167 16 complement complement VB cord-022053-idft1p6d 167 17 and and CC cord-022053-idft1p6d 167 18 in in IN cord-022053-idft1p6d 167 19 many many JJ cord-022053-idft1p6d 167 20 cases case NNS cord-022053-idft1p6d 167 21 replace replace VBP cord-022053-idft1p6d 167 22 the the DT cord-022053-idft1p6d 167 23 traditional traditional JJ cord-022053-idft1p6d 167 24 biochemical biochemical JJ cord-022053-idft1p6d 167 25 diagnosis diagnosis NN cord-022053-idft1p6d 167 26 of of IN cord-022053-idft1p6d 167 27 bacteria bacteria NNS cord-022053-idft1p6d 167 28 and and CC cord-022053-idft1p6d 167 29 yeasts yeast NNS cord-022053-idft1p6d 167 30 and and CC cord-022053-idft1p6d 167 31 can can MD cord-022053-idft1p6d 167 32 shorten shorten VB cord-022053-idft1p6d 167 33 turnaround turnaround NN cord-022053-idft1p6d 167 34 time time NN cord-022053-idft1p6d 168 1 ( ( -LRB- cord-022053-idft1p6d 168 2 TAT tat NN cord-022053-idft1p6d 168 3 ) ) -RRB- cord-022053-idft1p6d 168 4 by by IN cord-022053-idft1p6d 168 5 hours hour NNS cord-022053-idft1p6d 168 6 to to IN cord-022053-idft1p6d 168 7 days day NNS cord-022053-idft1p6d 169 1 ( ( -LRB- cord-022053-idft1p6d 169 2 depending depend VBG cord-022053-idft1p6d 169 3 There there EX cord-022053-idft1p6d 169 4 are be VBP cord-022053-idft1p6d 169 5 a a DT cord-022053-idft1p6d 169 6 variety variety NN cord-022053-idft1p6d 169 7 of of IN cord-022053-idft1p6d 169 8 focused focused JJ cord-022053-idft1p6d 169 9 assays assay NNS cord-022053-idft1p6d 169 10 in in IN cord-022053-idft1p6d 169 11 the the DT cord-022053-idft1p6d 169 12 clinical clinical JJ cord-022053-idft1p6d 169 13 microbiology microbiology NN cord-022053-idft1p6d 169 14 lab lab NN cord-022053-idft1p6d 169 15 and and CC cord-022053-idft1p6d 169 16 anatomic anatomic JJ cord-022053-idft1p6d 169 17 pathology pathology NN cord-022053-idft1p6d 169 18 samples sample NNS cord-022053-idft1p6d 169 19 that that WDT cord-022053-idft1p6d 169 20 query query VBP cord-022053-idft1p6d 169 21 one one CD cord-022053-idft1p6d 169 22 or or CC cord-022053-idft1p6d 169 23 a a DT cord-022053-idft1p6d 169 24 handful handful NN cord-022053-idft1p6d 169 25 of of IN cord-022053-idft1p6d 169 26 genes gene NNS cord-022053-idft1p6d 169 27 by by IN cord-022053-idft1p6d 169 28 amplification amplification NN cord-022053-idft1p6d 169 29 of of IN cord-022053-idft1p6d 169 30 the the DT cord-022053-idft1p6d 169 31 target target NN cord-022053-idft1p6d 169 32 . . . cord-022053-idft1p6d 170 1 The the DT cord-022053-idft1p6d 170 2 majority majority NN cord-022053-idft1p6d 170 3 of of IN cord-022053-idft1p6d 170 4 these these DT cord-022053-idft1p6d 170 5 relies relie NNS cord-022053-idft1p6d 170 6 on on IN cord-022053-idft1p6d 170 7 the the DT cord-022053-idft1p6d 170 8 PCR PCR NNP cord-022053-idft1p6d 170 9 and and CC cord-022053-idft1p6d 170 10 includes include VBZ cord-022053-idft1p6d 170 11 both both DT cord-022053-idft1p6d 170 12 qualitative qualitative JJ cord-022053-idft1p6d 170 13 and and CC cord-022053-idft1p6d 170 14 quantitative quantitative JJ cord-022053-idft1p6d 170 15 assays assay NNS cord-022053-idft1p6d 170 16 , , , cord-022053-idft1p6d 170 17 such such JJ cord-022053-idft1p6d 170 18 as as IN cord-022053-idft1p6d 170 19 those those DT cord-022053-idft1p6d 170 20 run run VBN cord-022053-idft1p6d 170 21 on on IN cord-022053-idft1p6d 170 22 real real JJ cord-022053-idft1p6d 170 23 - - HYPH cord-022053-idft1p6d 170 24 time time NN cord-022053-idft1p6d 170 25 PCR PCR NNP cord-022053-idft1p6d 170 26 platforms platform NNS cord-022053-idft1p6d 170 27 ( ( -LRB- cord-022053-idft1p6d 170 28 i.e. i.e. FW cord-022053-idft1p6d 170 29 , , , cord-022053-idft1p6d 170 30 the the DT cord-022053-idft1p6d 170 31 Lightcycler Lightcycler NNP cord-022053-idft1p6d 170 32 [ [ -LRB- cord-022053-idft1p6d 170 33 Roche Roche NNP cord-022053-idft1p6d 170 34 Diagnostics Diagnostics NNP cord-022053-idft1p6d 170 35 , , , cord-022053-idft1p6d 170 36 Indianapolis Indianapolis NNP cord-022053-idft1p6d 170 37 , , , cord-022053-idft1p6d 170 38 Indiana Indiana NNP cord-022053-idft1p6d 170 39 ] ] -RRB- cord-022053-idft1p6d 170 40 and and CC cord-022053-idft1p6d 170 41 the the DT cord-022053-idft1p6d 170 42 Smartcycler Smartcycler NNP cord-022053-idft1p6d 170 43 [ [ -LRB- cord-022053-idft1p6d 170 44 Cepheid Cepheid NNP cord-022053-idft1p6d 170 45 , , , cord-022053-idft1p6d 170 46 Sunnyvale Sunnyvale NNP cord-022053-idft1p6d 170 47 , , , cord-022053-idft1p6d 170 48 California California NNP cord-022053-idft1p6d 170 49 ] ] -RRB- cord-022053-idft1p6d 170 50 ) ) -RRB- cord-022053-idft1p6d 170 51 . . . cord-022053-idft1p6d 171 1 Target target NN cord-022053-idft1p6d 171 2 detection detection NN cord-022053-idft1p6d 171 3 is be VBZ cord-022053-idft1p6d 171 4 typically typically RB cord-022053-idft1p6d 171 5 by by IN cord-022053-idft1p6d 171 6 fluorescent fluorescent JJ cord-022053-idft1p6d 171 7 probes probe NNS cord-022053-idft1p6d 171 8 , , , cord-022053-idft1p6d 171 9 such such JJ cord-022053-idft1p6d 171 10 as as IN cord-022053-idft1p6d 171 11 TaqMan TaqMan NNP cord-022053-idft1p6d 171 12 . . . cord-022053-idft1p6d 172 1 60 60 CD cord-022053-idft1p6d 172 2 Single single JJ cord-022053-idft1p6d 172 3 - - HYPH cord-022053-idft1p6d 172 4 target target NN cord-022053-idft1p6d 172 5 PCR PCR NNP cord-022053-idft1p6d 172 6 has have VBZ cord-022053-idft1p6d 172 7 been be VBN cord-022053-idft1p6d 172 8 applied apply VBN cord-022053-idft1p6d 172 9 to to IN cord-022053-idft1p6d 172 10 fresh fresh JJ cord-022053-idft1p6d 172 11 , , , cord-022053-idft1p6d 172 12 frozen frozen JJ cord-022053-idft1p6d 172 13 , , , cord-022053-idft1p6d 172 14 and and CC cord-022053-idft1p6d 172 15 FFPE FFPE NNP cord-022053-idft1p6d 172 16 in in IN cord-022053-idft1p6d 172 17 anatomic anatomic JJ cord-022053-idft1p6d 172 18 pathology pathology NN cord-022053-idft1p6d 172 19 for for IN cord-022053-idft1p6d 172 20 a a DT cord-022053-idft1p6d 172 21 large large JJ cord-022053-idft1p6d 172 22 range range NN cord-022053-idft1p6d 172 23 of of IN cord-022053-idft1p6d 172 24 microorganisms microorganism NNS cord-022053-idft1p6d 172 25 but but CC cord-022053-idft1p6d 172 26 largely largely RB cord-022053-idft1p6d 172 27 through through IN cord-022053-idft1p6d 172 28 home home NN cord-022053-idft1p6d 172 29 - - HYPH cord-022053-idft1p6d 172 30 brew brew NN cord-022053-idft1p6d 172 31 or or CC cord-022053-idft1p6d 172 32 in in IN cord-022053-idft1p6d 172 33 - - HYPH cord-022053-idft1p6d 172 34 house house NN cord-022053-idft1p6d 172 35 assays assay NNS cord-022053-idft1p6d 172 36 and/or and/or CC cord-022053-idft1p6d 172 37 performance performance NN cord-022053-idft1p6d 172 38 by by IN cord-022053-idft1p6d 172 39 large large JJ cord-022053-idft1p6d 172 40 specialty specialty NN cord-022053-idft1p6d 172 41 reference reference NN cord-022053-idft1p6d 172 42 labs lab NNS cord-022053-idft1p6d 172 43 , , , cord-022053-idft1p6d 172 44 due due IN cord-022053-idft1p6d 172 45 to to IN cord-022053-idft1p6d 172 46 the the DT cord-022053-idft1p6d 172 47 challenges challenge NNS cord-022053-idft1p6d 172 48 of of IN cord-022053-idft1p6d 172 49 control control NN cord-022053-idft1p6d 172 50 tissue tissue NN cord-022053-idft1p6d 172 51 , , , cord-022053-idft1p6d 172 52 validation validation NN cord-022053-idft1p6d 172 53 , , , cord-022053-idft1p6d 172 54 and and CC cord-022053-idft1p6d 172 55 complexity complexity NN cord-022053-idft1p6d 172 56 of of IN cord-022053-idft1p6d 172 57 interpretation interpretation NN cord-022053-idft1p6d 172 58 . . . cord-022053-idft1p6d 173 1 Recent recent JJ cord-022053-idft1p6d 173 2 developments development NNS cord-022053-idft1p6d 173 3 in in IN cord-022053-idft1p6d 173 4 this this DT cord-022053-idft1p6d 173 5 area area NN cord-022053-idft1p6d 173 6 are be VBP cord-022053-idft1p6d 173 7 based base VBN cord-022053-idft1p6d 173 8 on on IN cord-022053-idft1p6d 173 9 the the DT cord-022053-idft1p6d 173 10 same same JJ cord-022053-idft1p6d 173 11 technology technology NN cord-022053-idft1p6d 173 12 but but CC cord-022053-idft1p6d 173 13 are be VBP cord-022053-idft1p6d 173 14 innovative innovative JJ cord-022053-idft1p6d 173 15 in in IN cord-022053-idft1p6d 173 16 their -PRON- PRP$ cord-022053-idft1p6d 173 17 convenience convenience NN cord-022053-idft1p6d 173 18 , , , cord-022053-idft1p6d 173 19 detection detection NN cord-022053-idft1p6d 173 20 method method NN cord-022053-idft1p6d 173 21 , , , cord-022053-idft1p6d 173 22 and and CC cord-022053-idft1p6d 173 23 , , , cord-022053-idft1p6d 173 24 in in IN cord-022053-idft1p6d 173 25 some some DT cord-022053-idft1p6d 173 26 instances instance NNS cord-022053-idft1p6d 173 27 , , , cord-022053-idft1p6d 173 28 sensitivity sensitivity NN cord-022053-idft1p6d 173 29 . . . cord-022053-idft1p6d 174 1 For for IN cord-022053-idft1p6d 174 2 example example NN cord-022053-idft1p6d 174 3 , , , cord-022053-idft1p6d 174 4 using use VBG cord-022053-idft1p6d 174 5 standard standard JJ cord-022053-idft1p6d 174 6 real real JJ cord-022053-idft1p6d 174 7 - - HYPH cord-022053-idft1p6d 174 8 time time NN cord-022053-idft1p6d 174 9 PCR pcr NN cord-022053-idft1p6d 174 10 technology technology NN cord-022053-idft1p6d 174 11 , , , cord-022053-idft1p6d 174 12 FDA FDA NNP cord-022053-idft1p6d 174 13 - - HYPH cord-022053-idft1p6d 174 14 approved approve VBN cord-022053-idft1p6d 174 15 assays assay NNS cord-022053-idft1p6d 174 16 , , , cord-022053-idft1p6d 174 17 such such JJ cord-022053-idft1p6d 174 18 as as IN cord-022053-idft1p6d 174 19 the the DT cord-022053-idft1p6d 174 20 Prodesse Prodesse NNP cord-022053-idft1p6d 174 21 kits kit NNS cord-022053-idft1p6d 174 22 ( ( -LRB- cord-022053-idft1p6d 174 23 Hologic Hologic NNP cord-022053-idft1p6d 174 24 Gen Gen NNP cord-022053-idft1p6d 174 25 - - HYPH cord-022053-idft1p6d 174 26 Probe Probe NNP cord-022053-idft1p6d 174 27 ) ) -RRB- cord-022053-idft1p6d 174 28 , , , cord-022053-idft1p6d 174 29 provide provide VB cord-022053-idft1p6d 174 30 convenient convenient JJ cord-022053-idft1p6d 174 31 detection detection NN cord-022053-idft1p6d 174 32 of of IN cord-022053-idft1p6d 174 33 small small JJ cord-022053-idft1p6d 174 34 sets set NNS cord-022053-idft1p6d 174 35 of of IN cord-022053-idft1p6d 174 36 respiratory respiratory JJ cord-022053-idft1p6d 174 37 viruses virus NNS cord-022053-idft1p6d 174 38 . . . cord-022053-idft1p6d 175 1 The the DT cord-022053-idft1p6d 175 2 Xpert Xpert NNP cord-022053-idft1p6d 175 3 system system NN cord-022053-idft1p6d 175 4 ( ( -LRB- cord-022053-idft1p6d 175 5 Cepheid Cepheid NNP cord-022053-idft1p6d 175 6 ) ) -RRB- cord-022053-idft1p6d 175 7 has have VBZ cord-022053-idft1p6d 175 8 had have VBN cord-022053-idft1p6d 175 9 a a DT cord-022053-idft1p6d 175 10 large large JJ cord-022053-idft1p6d 175 11 impact impact NN cord-022053-idft1p6d 175 12 on on IN cord-022053-idft1p6d 175 13 the the DT cord-022053-idft1p6d 175 14 clinical clinical JJ cord-022053-idft1p6d 175 15 lab lab NN cord-022053-idft1p6d 175 16 due due IN cord-022053-idft1p6d 175 17 to to IN cord-022053-idft1p6d 175 18 its -PRON- PRP$ cord-022053-idft1p6d 175 19 ease ease NN cord-022053-idft1p6d 175 20 of of IN cord-022053-idft1p6d 175 21 use use NN cord-022053-idft1p6d 175 22 ( ( -LRB- cord-022053-idft1p6d 175 23 sample sample NN cord-022053-idft1p6d 175 24 - - HYPH cord-022053-idft1p6d 175 25 to to IN cord-022053-idft1p6d 175 26 - - HYPH cord-022053-idft1p6d 175 27 result result NN cord-022053-idft1p6d 175 28 platform platform NN cord-022053-idft1p6d 175 29 ) ) -RRB- cord-022053-idft1p6d 175 30 , , , cord-022053-idft1p6d 175 31 excellent excellent JJ cord-022053-idft1p6d 175 32 performance performance NN cord-022053-idft1p6d 175 33 , , , cord-022053-idft1p6d 175 34 and and CC cord-022053-idft1p6d 175 35 rapid rapid JJ cord-022053-idft1p6d 175 36 TAT TAT NNP cord-022053-idft1p6d 175 37 ( ( -LRB- cord-022053-idft1p6d 175 38 approximately approximately RB cord-022053-idft1p6d 175 39 1 1 CD cord-022053-idft1p6d 175 40 hour hour NN cord-022053-idft1p6d 175 41 ) ) -RRB- cord-022053-idft1p6d 175 42 . . . cord-022053-idft1p6d 176 1 Detection detection NN cord-022053-idft1p6d 176 2 is be VBZ cord-022053-idft1p6d 176 3 by by IN cord-022053-idft1p6d 176 4 melt melt NN cord-022053-idft1p6d 176 5 curve curve NN cord-022053-idft1p6d 176 6 analysis analysis NN cord-022053-idft1p6d 176 7 rather rather RB cord-022053-idft1p6d 176 8 than than IN cord-022053-idft1p6d 176 9 fluorescence fluorescence NN cord-022053-idft1p6d 176 10 . . . cord-022053-idft1p6d 177 1 This this DT cord-022053-idft1p6d 177 2 platform platform NN cord-022053-idft1p6d 177 3 offers offer VBZ cord-022053-idft1p6d 177 4 a a DT cord-022053-idft1p6d 177 5 variety variety NN cord-022053-idft1p6d 177 6 of of IN cord-022053-idft1p6d 177 7 cartridges cartridge NNS cord-022053-idft1p6d 177 8 ( ( -LRB- cord-022053-idft1p6d 177 9 e.g. e.g. RB cord-022053-idft1p6d 177 10 , , , cord-022053-idft1p6d 177 11 C. C. NNP cord-022053-idft1p6d 177 12 difficile difficile NN cord-022053-idft1p6d 177 13 , , , cord-022053-idft1p6d 177 14 MRSA MRSA NNP cord-022053-idft1p6d 177 15 , , , cord-022053-idft1p6d 177 16 MTB MTB NNP cord-022053-idft1p6d 177 17 / / SYM cord-022053-idft1p6d 177 18 RIF RIF NNP cord-022053-idft1p6d 177 19 ) ) -RRB- cord-022053-idft1p6d 177 20 focused focus VBD cord-022053-idft1p6d 177 21 on on IN cord-022053-idft1p6d 177 22 quick quick JJ cord-022053-idft1p6d 177 23 answers answer NNS cord-022053-idft1p6d 177 24 to to IN cord-022053-idft1p6d 177 25 major major JJ cord-022053-idft1p6d 177 26 clinical clinical JJ cord-022053-idft1p6d 177 27 decision decision NN cord-022053-idft1p6d 177 28 points point NNS cord-022053-idft1p6d 177 29 . . . cord-022053-idft1p6d 178 1 [ [ -LRB- cord-022053-idft1p6d 178 2 61 61 CD cord-022053-idft1p6d 178 3 ] ] -RRB- cord-022053-idft1p6d 178 4 [ [ -LRB- cord-022053-idft1p6d 178 5 62 62 CD cord-022053-idft1p6d 178 6 ] ] -RRB- cord-022053-idft1p6d 178 7 [ [ -LRB- cord-022053-idft1p6d 178 8 63 63 CD cord-022053-idft1p6d 178 9 ] ] -RRB- cord-022053-idft1p6d 178 10 [ [ -LRB- cord-022053-idft1p6d 178 11 64 64 CD cord-022053-idft1p6d 178 12 ] ] -RRB- cord-022053-idft1p6d 179 1 Newer new JJR cord-022053-idft1p6d 179 2 assays assay NNS cord-022053-idft1p6d 179 3 from from IN cord-022053-idft1p6d 179 4 Cepheid Cepheid NNP cord-022053-idft1p6d 179 5 are be VBP cord-022053-idft1p6d 179 6 in in IN cord-022053-idft1p6d 179 7 development development NN cord-022053-idft1p6d 179 8 for for IN cord-022053-idft1p6d 179 9 FFPE FFPE NNP cord-022053-idft1p6d 179 10 , , , cord-022053-idft1p6d 179 11 which which WDT cord-022053-idft1p6d 179 12 will will MD cord-022053-idft1p6d 179 13 include include VB cord-022053-idft1p6d 179 14 microbiologic microbiologic JJ cord-022053-idft1p6d 179 15 applications application NNS cord-022053-idft1p6d 179 16 . . . cord-022053-idft1p6d 180 1 For for IN cord-022053-idft1p6d 180 2 novel novel JJ cord-022053-idft1p6d 180 3 detection detection NN cord-022053-idft1p6d 180 4 methods method NNS cord-022053-idft1p6d 180 5 and and CC cord-022053-idft1p6d 180 6 increased increase VBN cord-022053-idft1p6d 180 7 sensitivity sensitivity NN cord-022053-idft1p6d 180 8 , , , cord-022053-idft1p6d 180 9 the the DT cord-022053-idft1p6d 180 10 T2MR T2MR NNP cord-022053-idft1p6d 180 11 platform platform NN cord-022053-idft1p6d 180 12 ( ( -LRB- cord-022053-idft1p6d 180 13 T2 T2 NNP cord-022053-idft1p6d 180 14 Biosystems Biosystems NNP cord-022053-idft1p6d 180 15 , , , cord-022053-idft1p6d 180 16 Lexington Lexington NNP cord-022053-idft1p6d 180 17 , , , cord-022053-idft1p6d 180 18 Massachusetts Massachusetts NNP cord-022053-idft1p6d 180 19 ) ) -RRB- cord-022053-idft1p6d 180 20 is be VBZ cord-022053-idft1p6d 180 21 one one CD cord-022053-idft1p6d 180 22 of of IN cord-022053-idft1p6d 180 23 the the DT cord-022053-idft1p6d 180 24 most most RBS cord-022053-idft1p6d 180 25 innovative innovative JJ cord-022053-idft1p6d 180 26 technologies technology NNS cord-022053-idft1p6d 180 27 . . . cord-022053-idft1p6d 181 1 It -PRON- PRP cord-022053-idft1p6d 181 2 is be VBZ cord-022053-idft1p6d 181 3 a a DT cord-022053-idft1p6d 181 4 complete complete JJ cord-022053-idft1p6d 181 5 sampleto sampleto NN cord-022053-idft1p6d 181 6 - - HYPH cord-022053-idft1p6d 181 7 result result NN cord-022053-idft1p6d 181 8 platform platform NN cord-022053-idft1p6d 181 9 that that WDT cord-022053-idft1p6d 181 10 relies rely VBZ cord-022053-idft1p6d 181 11 on on IN cord-022053-idft1p6d 181 12 detection detection NN cord-022053-idft1p6d 181 13 of of IN cord-022053-idft1p6d 181 14 pathogen pathogen NN cord-022053-idft1p6d 181 15 - - HYPH cord-022053-idft1p6d 181 16 specific specific JJ cord-022053-idft1p6d 181 17 amplicons amplicon NNS cord-022053-idft1p6d 181 18 by by IN cord-022053-idft1p6d 181 19 hybridization hybridization NN cord-022053-idft1p6d 181 20 with with IN cord-022053-idft1p6d 181 21 tagged tagged JJ cord-022053-idft1p6d 181 22 superparamagnetic superparamagnetic NNP cord-022053-idft1p6d 181 23 particles particle NNS cord-022053-idft1p6d 181 24 . . . cord-022053-idft1p6d 182 1 65 65 CD cord-022053-idft1p6d 183 1 The the DT cord-022053-idft1p6d 183 2 T2Candida T2Candida NNP cord-022053-idft1p6d 183 3 Panel Panel NNP cord-022053-idft1p6d 183 4 ( ( -LRB- cord-022053-idft1p6d 183 5 T2 T2 NNP cord-022053-idft1p6d 183 6 Biosystems Biosystems NNP cord-022053-idft1p6d 183 7 ) ) -RRB- cord-022053-idft1p6d 183 8 is be VBZ cord-022053-idft1p6d 183 9 the the DT cord-022053-idft1p6d 183 10 only only JJ cord-022053-idft1p6d 183 11 FDA FDA NNP cord-022053-idft1p6d 183 12 - - HYPH cord-022053-idft1p6d 183 13 approved approve VBN cord-022053-idft1p6d 183 14 system system NN cord-022053-idft1p6d 183 15 that that WDT cord-022053-idft1p6d 183 16 directly directly RB cord-022053-idft1p6d 183 17 analyzes analyze VBZ cord-022053-idft1p6d 183 18 blood blood NN cord-022053-idft1p6d 183 19 ( ( -LRB- cord-022053-idft1p6d 183 20 without without IN cord-022053-idft1p6d 183 21 culturing culture VBG cord-022053-idft1p6d 183 22 ) ) -RRB- cord-022053-idft1p6d 183 23 and and CC cord-022053-idft1p6d 183 24 has have VBZ cord-022053-idft1p6d 183 25 demonstrated demonstrate VBN cord-022053-idft1p6d 183 26 impressive impressive JJ cord-022053-idft1p6d 183 27 results result NNS cord-022053-idft1p6d 183 28 in in IN cord-022053-idft1p6d 183 29 clinical clinical JJ cord-022053-idft1p6d 183 30 trials trial NNS cord-022053-idft1p6d 183 31 ( ( -LRB- cord-022053-idft1p6d 183 32 91 91 CD cord-022053-idft1p6d 183 33 % % NN cord-022053-idft1p6d 183 34 sensitivity sensitivity NN cord-022053-idft1p6d 183 35 with with IN cord-022053-idft1p6d 183 36 a a DT cord-022053-idft1p6d 183 37 4.2-hour 4.2-hour CD cord-022053-idft1p6d 183 38 TAT tat NN cord-022053-idft1p6d 183 39 ) ) -RRB- cord-022053-idft1p6d 183 40 . . . cord-022053-idft1p6d 184 1 66 66 CD cord-022053-idft1p6d 185 1 T2 T2 NNP cord-022053-idft1p6d 185 2 Biosystems Biosystems NNP cord-022053-idft1p6d 185 3 is be VBZ cord-022053-idft1p6d 185 4 currently currently RB cord-022053-idft1p6d 185 5 developing develop VBG cord-022053-idft1p6d 185 6 a a DT cord-022053-idft1p6d 185 7 bacterial bacterial JJ cord-022053-idft1p6d 185 8 panel panel NN cord-022053-idft1p6d 185 9 as as RB cord-022053-idft1p6d 185 10 well well RB cord-022053-idft1p6d 185 11 , , , cord-022053-idft1p6d 185 12 which which WDT cord-022053-idft1p6d 185 13 is be VBZ cord-022053-idft1p6d 185 14 reported report VBN cord-022053-idft1p6d 185 15 to to TO cord-022053-idft1p6d 185 16 target target VB cord-022053-idft1p6d 185 17 Acinetobacter Acinetobacter NNP cord-022053-idft1p6d 185 18 baumannii baumannii NN cord-022053-idft1p6d 185 19 , , , cord-022053-idft1p6d 185 20 E. E. NNP cord-022053-idft1p6d 185 21 faecium faecium NNP cord-022053-idft1p6d 185 22 , , , cord-022053-idft1p6d 185 23 K. K. NNP cord-022053-idft1p6d 185 24 pneumoniae pneumoniae NN cord-022053-idft1p6d 185 25 , , , cord-022053-idft1p6d 185 26 P. P. NNP cord-022053-idft1p6d 185 27 aeruginosa aeruginosa NN cord-022053-idft1p6d 185 28 , , , cord-022053-idft1p6d 185 29 and and CC cord-022053-idft1p6d 185 30 SA SA NNP cord-022053-idft1p6d 185 31 . . . cord-022053-idft1p6d 186 1 67 67 CD cord-022053-idft1p6d 187 1 Although although IN cord-022053-idft1p6d 187 2 PCR PCR NNP cord-022053-idft1p6d 187 3 remains remain VBZ cord-022053-idft1p6d 187 4 the the DT cord-022053-idft1p6d 187 5 most most RBS cord-022053-idft1p6d 187 6 common common JJ cord-022053-idft1p6d 187 7 means mean NNS cord-022053-idft1p6d 187 8 of of IN cord-022053-idft1p6d 187 9 nucleic nucleic JJ cord-022053-idft1p6d 187 10 acid acid NN cord-022053-idft1p6d 187 11 amplification amplification NN cord-022053-idft1p6d 187 12 , , , cord-022053-idft1p6d 187 13 other other JJ cord-022053-idft1p6d 187 14 technologies technology NNS cord-022053-idft1p6d 187 15 have have VBP cord-022053-idft1p6d 187 16 been be VBN cord-022053-idft1p6d 187 17 developed develop VBN cord-022053-idft1p6d 187 18 that that WDT cord-022053-idft1p6d 187 19 address address NN cord-022053-idft1p6d 187 20 the the DT cord-022053-idft1p6d 187 21 presence presence NN cord-022053-idft1p6d 187 22 of of IN cord-022053-idft1p6d 187 23 single single JJ cord-022053-idft1p6d 187 24 targets target NNS cord-022053-idft1p6d 187 25 . . . cord-022053-idft1p6d 188 1 Transcription transcription NN cord-022053-idft1p6d 188 2 - - HYPH cord-022053-idft1p6d 188 3 mediated mediate VBN cord-022053-idft1p6d 188 4 amplification amplification NN cord-022053-idft1p6d 188 5 ( ( -LRB- cord-022053-idft1p6d 188 6 TMA TMA NNP cord-022053-idft1p6d 188 7 ) ) -RRB- cord-022053-idft1p6d 188 8 has have VBZ cord-022053-idft1p6d 188 9 been be VBN cord-022053-idft1p6d 188 10 applied apply VBN cord-022053-idft1p6d 188 11 to to IN cord-022053-idft1p6d 188 12 mycobacteria mycobacterium NNS cord-022053-idft1p6d 188 13 , , , cord-022053-idft1p6d 188 14 HCV HCV NNP cord-022053-idft1p6d 188 15 , , , cord-022053-idft1p6d 188 16 E. E. NNP cord-022053-idft1p6d 188 17 coli coli NNS cord-022053-idft1p6d 188 18 , , , cord-022053-idft1p6d 188 19 and and CC cord-022053-idft1p6d 188 20 Listeria Listeria NNP cord-022053-idft1p6d 188 21 , , , cord-022053-idft1p6d 188 22 where where WRB cord-022053-idft1p6d 188 23 RNA RNA NNP cord-022053-idft1p6d 188 24 is be VBZ cord-022053-idft1p6d 188 25 bound bind VBN cord-022053-idft1p6d 188 26 by by IN cord-022053-idft1p6d 188 27 a a DT cord-022053-idft1p6d 188 28 target target NN cord-022053-idft1p6d 188 29 oligo oligo NN cord-022053-idft1p6d 188 30 and and CC cord-022053-idft1p6d 188 31 then then RB cord-022053-idft1p6d 188 32 acted act VBD cord-022053-idft1p6d 188 33 upon upon IN cord-022053-idft1p6d 188 34 , , , cord-022053-idft1p6d 188 35 in in IN cord-022053-idft1p6d 188 36 sequence sequence NN cord-022053-idft1p6d 188 37 , , , cord-022053-idft1p6d 188 38 by by IN cord-022053-idft1p6d 188 39 reverse reverse JJ cord-022053-idft1p6d 188 40 transcriptase transcriptase NN cord-022053-idft1p6d 188 41 ( ( -LRB- cord-022053-idft1p6d 188 42 RT RT NNP cord-022053-idft1p6d 188 43 ) ) -RRB- cord-022053-idft1p6d 188 44 ( ( -LRB- cord-022053-idft1p6d 188 45 to to TO cord-022053-idft1p6d 188 46 produce produce VB cord-022053-idft1p6d 188 47 cDNA cDNA NNP cord-022053-idft1p6d 188 48 ) ) -RRB- cord-022053-idft1p6d 188 49 , , , cord-022053-idft1p6d 188 50 RNase rnase NN cord-022053-idft1p6d 188 51 H h NN cord-022053-idft1p6d 188 52 ( ( -LRB- cord-022053-idft1p6d 188 53 to to TO cord-022053-idft1p6d 188 54 degrade degrade VB cord-022053-idft1p6d 188 55 RNA RNA NNP cord-022053-idft1p6d 188 56 template template NN cord-022053-idft1p6d 188 57 ) ) -RRB- cord-022053-idft1p6d 188 58 , , , cord-022053-idft1p6d 188 59 RT RT NNP cord-022053-idft1p6d 188 60 again again RB cord-022053-idft1p6d 188 61 to to TO cord-022053-idft1p6d 188 62 produce produce VB cord-022053-idft1p6d 188 63 a a DT cord-022053-idft1p6d 188 64 double double RB cord-022053-idft1p6d 188 65 - - HYPH cord-022053-idft1p6d 188 66 stranded strand VBN cord-022053-idft1p6d 188 67 DNA dna NN cord-022053-idft1p6d 188 68 promoter promoter NN cord-022053-idft1p6d 188 69 sequence sequence NN cord-022053-idft1p6d 188 70 , , , cord-022053-idft1p6d 188 71 and and CC cord-022053-idft1p6d 188 72 then then RB cord-022053-idft1p6d 188 73 RNA RNA NNP cord-022053-idft1p6d 188 74 polymerase polymerase NN cord-022053-idft1p6d 188 75 to to TO cord-022053-idft1p6d 188 76 produce produce VB cord-022053-idft1p6d 188 77 many many JJ cord-022053-idft1p6d 188 78 copies copy NNS cord-022053-idft1p6d 188 79 of of IN cord-022053-idft1p6d 188 80 single single RB cord-022053-idft1p6d 188 81 - - HYPH cord-022053-idft1p6d 188 82 stranded strand VBN cord-022053-idft1p6d 188 83 RNA RNA NNP cord-022053-idft1p6d 188 84 - - : cord-022053-idft1p6d 188 85 then then RB cord-022053-idft1p6d 188 86 the the DT cord-022053-idft1p6d 188 87 process process NN cord-022053-idft1p6d 188 88 repeats repeat VBZ cord-022053-idft1p6d 188 89 itself -PRON- PRP cord-022053-idft1p6d 188 90 . . . cord-022053-idft1p6d 189 1 Another another DT cord-022053-idft1p6d 189 2 isothermal isothermal JJ cord-022053-idft1p6d 189 3 reaction reaction NN cord-022053-idft1p6d 189 4 occurs occur VBZ cord-022053-idft1p6d 189 5 in in IN cord-022053-idft1p6d 189 6 loop loop NN cord-022053-idft1p6d 189 7 - - HYPH cord-022053-idft1p6d 189 8 mediated mediate VBN cord-022053-idft1p6d 189 9 isothermal isothermal JJ cord-022053-idft1p6d 189 10 amplification amplification NN cord-022053-idft1p6d 189 11 , , , cord-022053-idft1p6d 189 12 which which WDT cord-022053-idft1p6d 189 13 uses use VBZ cord-022053-idft1p6d 189 14 a a DT cord-022053-idft1p6d 189 15 group group NN cord-022053-idft1p6d 189 16 of of IN cord-022053-idft1p6d 189 17 four four CD cord-022053-idft1p6d 189 18 to to TO cord-022053-idft1p6d 189 19 six six CD cord-022053-idft1p6d 189 20 primers primer NNS cord-022053-idft1p6d 189 21 and and CC cord-022053-idft1p6d 189 22 Bst Bst NNP cord-022053-idft1p6d 189 23 DNA DNA NNP cord-022053-idft1p6d 189 24 polymerase polymerase NN cord-022053-idft1p6d 189 25 , , , cord-022053-idft1p6d 189 26 with with IN cord-022053-idft1p6d 189 27 the the DT cord-022053-idft1p6d 189 28 creation creation NN cord-022053-idft1p6d 189 29 of of IN cord-022053-idft1p6d 189 30 complimentary complimentary JJ cord-022053-idft1p6d 189 31 sites site NNS cord-022053-idft1p6d 189 32 to to TO cord-022053-idft1p6d 189 33 generate generate VB cord-022053-idft1p6d 189 34 exponentially exponentially RB cord-022053-idft1p6d 189 35 amplified amplify VBN cord-022053-idft1p6d 189 36 loop loop NN cord-022053-idft1p6d 189 37 structures structure NNS cord-022053-idft1p6d 189 38 . . . cord-022053-idft1p6d 190 1 These these DT cord-022053-idft1p6d 190 2 assays assay NNS cord-022053-idft1p6d 190 3 have have VBP cord-022053-idft1p6d 190 4 been be VBN cord-022053-idft1p6d 190 5 developed develop VBN cord-022053-idft1p6d 190 6 for for IN cord-022053-idft1p6d 190 7 a a DT cord-022053-idft1p6d 190 8 wide wide JJ cord-022053-idft1p6d 190 9 range range NN cord-022053-idft1p6d 190 10 of of IN cord-022053-idft1p6d 190 11 targets target NNS cord-022053-idft1p6d 190 12 and and CC cord-022053-idft1p6d 190 13 produce produce VB cord-022053-idft1p6d 190 14 larger large JJR cord-022053-idft1p6d 190 15 quantities quantity NNS cord-022053-idft1p6d 190 16 of of IN cord-022053-idft1p6d 190 17 DNA dna NN cord-022053-idft1p6d 190 18 than than IN cord-022053-idft1p6d 190 19 traditional traditional JJ cord-022053-idft1p6d 190 20 PCR pcr NN cord-022053-idft1p6d 190 21 in in IN cord-022053-idft1p6d 190 22 a a DT cord-022053-idft1p6d 190 23 matter matter NN cord-022053-idft1p6d 190 24 of of IN cord-022053-idft1p6d 190 25 minutes minute NNS cord-022053-idft1p6d 190 26 to to IN cord-022053-idft1p6d 190 27 hours hour NNS cord-022053-idft1p6d 190 28 . . . cord-022053-idft1p6d 191 1 This this DT cord-022053-idft1p6d 191 2 technique technique NN cord-022053-idft1p6d 191 3 has have VBZ cord-022053-idft1p6d 191 4 been be VBN cord-022053-idft1p6d 191 5 applied apply VBN cord-022053-idft1p6d 191 6 to to IN cord-022053-idft1p6d 191 7 viruses virus NNS cord-022053-idft1p6d 191 8 , , , cord-022053-idft1p6d 191 9 bacteria bacteria NNS cord-022053-idft1p6d 191 10 , , , cord-022053-idft1p6d 191 11 protists protist NNS cord-022053-idft1p6d 191 12 , , , cord-022053-idft1p6d 191 13 fungi fungus NNS cord-022053-idft1p6d 191 14 , , , cord-022053-idft1p6d 191 15 and and CC cord-022053-idft1p6d 191 16 mycobacteria mycobacterium NNS cord-022053-idft1p6d 191 17 in in IN cord-022053-idft1p6d 191 18 a a DT cord-022053-idft1p6d 191 19 point point NN cord-022053-idft1p6d 191 20 of of IN cord-022053-idft1p6d 191 21 care care NN cord-022053-idft1p6d 191 22 manner manner NN cord-022053-idft1p6d 191 23 . . . cord-022053-idft1p6d 192 1 [ [ -LRB- cord-022053-idft1p6d 192 2 68 68 CD cord-022053-idft1p6d 192 3 ] ] -RRB- cord-022053-idft1p6d 192 4 [ [ -LRB- cord-022053-idft1p6d 192 5 69 69 CD cord-022053-idft1p6d 192 6 ] ] -RRB- cord-022053-idft1p6d 192 7 [ [ -LRB- cord-022053-idft1p6d 192 8 70 70 CD cord-022053-idft1p6d 192 9 ] ] -RRB- cord-022053-idft1p6d 192 10 [ [ -LRB- cord-022053-idft1p6d 192 11 71 71 CD cord-022053-idft1p6d 192 12 ] ] -RRB- cord-022053-idft1p6d 193 1 [ [ -LRB- cord-022053-idft1p6d 193 2 72 72 CD cord-022053-idft1p6d 193 3 ] ] -RRB- cord-022053-idft1p6d 193 4 LAMP lamp NN cord-022053-idft1p6d 193 5 techniques technique NNS cord-022053-idft1p6d 193 6 are be VBP cord-022053-idft1p6d 193 7 limited limit VBN cord-022053-idft1p6d 193 8 by by IN cord-022053-idft1p6d 193 9 the the DT cord-022053-idft1p6d 193 10 challenges challenge NNS cord-022053-idft1p6d 193 11 of of IN cord-022053-idft1p6d 193 12 complex complex JJ cord-022053-idft1p6d 193 13 primer primer NN cord-022053-idft1p6d 193 14 design design NN cord-022053-idft1p6d 193 15 , , , cord-022053-idft1p6d 193 16 limited limited JJ cord-022053-idft1p6d 193 17 ability ability NN cord-022053-idft1p6d 193 18 to to TO cord-022053-idft1p6d 193 19 multiplex multiplex NN cord-022053-idft1p6d 193 20 , , , cord-022053-idft1p6d 193 21 and and CC cord-022053-idft1p6d 193 22 common common JJ cord-022053-idft1p6d 193 23 inhibitors inhibitor NNS cord-022053-idft1p6d 193 24 of of IN cord-022053-idft1p6d 193 25 the the DT cord-022053-idft1p6d 193 26 enzymes enzyme NNS cord-022053-idft1p6d 193 27 in in IN cord-022053-idft1p6d 193 28 certain certain JJ cord-022053-idft1p6d 193 29 human human JJ cord-022053-idft1p6d 193 30 samples sample NNS cord-022053-idft1p6d 193 31 , , , cord-022053-idft1p6d 193 32 including include VBG cord-022053-idft1p6d 193 33 blood blood NN cord-022053-idft1p6d 193 34 . . . cord-022053-idft1p6d 194 1 A a DT cord-022053-idft1p6d 194 2 last last JJ cord-022053-idft1p6d 194 3 isothermal isothermal JJ cord-022053-idft1p6d 194 4 amplification amplification NN cord-022053-idft1p6d 194 5 is be VBZ cord-022053-idft1p6d 194 6 Massachusetts Massachusetts NNP cord-022053-idft1p6d 194 7 ) ) -RRB- cord-022053-idft1p6d 194 8 and and CC cord-022053-idft1p6d 194 9 consist consist VBP cord-022053-idft1p6d 194 10 of of IN cord-022053-idft1p6d 194 11 single single RB cord-022053-idft1p6d 194 12 - - HYPH cord-022053-idft1p6d 194 13 stranded strand VBN cord-022053-idft1p6d 194 14 DNA dna NN cord-022053-idft1p6d 194 15 probes probe NNS cord-022053-idft1p6d 194 16 tagged tag VBN cord-022053-idft1p6d 194 17 with with IN cord-022053-idft1p6d 194 18 acridinium acridinium NNP cord-022053-idft1p6d 194 19 esters ester NNS cord-022053-idft1p6d 194 20 that that WDT cord-022053-idft1p6d 194 21 hybridize hybridize VBP cord-022053-idft1p6d 194 22 to to IN cord-022053-idft1p6d 194 23 rRNA rRNA NNP cord-022053-idft1p6d 194 24 . . . cord-022053-idft1p6d 195 1 Tests test NNS cord-022053-idft1p6d 195 2 are be VBP cord-022053-idft1p6d 195 3 read read VBN cord-022053-idft1p6d 195 4 in in IN cord-022053-idft1p6d 195 5 a a DT cord-022053-idft1p6d 195 6 luminometer luminometer NN cord-022053-idft1p6d 195 7 . . . cord-022053-idft1p6d 196 1 Because because IN cord-022053-idft1p6d 196 2 there there EX cord-022053-idft1p6d 196 3 is be VBZ cord-022053-idft1p6d 196 4 no no DT cord-022053-idft1p6d 196 5 amplification amplification NN cord-022053-idft1p6d 196 6 , , , cord-022053-idft1p6d 196 7 probe probe NN cord-022053-idft1p6d 196 8 - - HYPH cord-022053-idft1p6d 196 9 based base VBN cord-022053-idft1p6d 196 10 assays assay NNS cord-022053-idft1p6d 196 11 generally generally RB cord-022053-idft1p6d 196 12 suffer suffer VBP cord-022053-idft1p6d 196 13 low low JJ cord-022053-idft1p6d 196 14 sensitivity sensitivity NN cord-022053-idft1p6d 196 15 and and CC cord-022053-idft1p6d 196 16 are be VBP cord-022053-idft1p6d 196 17 reserved reserve VBN cord-022053-idft1p6d 196 18 for for IN cord-022053-idft1p6d 196 19 culture culture NN cord-022053-idft1p6d 196 20 confirmation confirmation NN cord-022053-idft1p6d 196 21 , , , cord-022053-idft1p6d 196 22 where where WRB cord-022053-idft1p6d 196 23 organisms organism NNS cord-022053-idft1p6d 196 24 are be VBP cord-022053-idft1p6d 196 25 present present JJ cord-022053-idft1p6d 196 26 in in IN cord-022053-idft1p6d 196 27 high high JJ cord-022053-idft1p6d 196 28 numbers number NNS cord-022053-idft1p6d 196 29 . . . cord-022053-idft1p6d 197 1 AdvanDX advandx NN cord-022053-idft1p6d 197 2 ( ( -LRB- cord-022053-idft1p6d 197 3 Woburn Woburn NNP cord-022053-idft1p6d 197 4 , , , cord-022053-idft1p6d 197 5 Massachusetts Massachusetts NNP cord-022053-idft1p6d 197 6 ) ) -RRB- cord-022053-idft1p6d 197 7 has have VBZ cord-022053-idft1p6d 197 8 produced produce VBN cord-022053-idft1p6d 197 9 a a DT cord-022053-idft1p6d 197 10 series series NN cord-022053-idft1p6d 197 11 of of IN cord-022053-idft1p6d 197 12 probe probe NN cord-022053-idft1p6d 197 13 - - HYPH cord-022053-idft1p6d 197 14 based base VBN cord-022053-idft1p6d 197 15 assays assay NNS cord-022053-idft1p6d 197 16 using use VBG cord-022053-idft1p6d 197 17 peptide peptide NN cord-022053-idft1p6d 197 18 nucleic nucleic JJ cord-022053-idft1p6d 197 19 acid acid NN cord-022053-idft1p6d 197 20 ( ( -LRB- cord-022053-idft1p6d 197 21 PNA PNA NNP cord-022053-idft1p6d 197 22 ) ) -RRB- cord-022053-idft1p6d 197 23 probes probe NNS cord-022053-idft1p6d 197 24 tagged tag VBN cord-022053-idft1p6d 197 25 with with IN cord-022053-idft1p6d 197 26 fluorescent fluorescent JJ cord-022053-idft1p6d 197 27 markers marker NNS cord-022053-idft1p6d 197 28 . . . cord-022053-idft1p6d 198 1 46 46 CD cord-022053-idft1p6d 198 2 PNA PNA NNP cord-022053-idft1p6d 198 3 probes probe NNS cord-022053-idft1p6d 198 4 have have VBP cord-022053-idft1p6d 198 5 several several JJ cord-022053-idft1p6d 198 6 advantages advantage NNS cord-022053-idft1p6d 198 7 over over IN cord-022053-idft1p6d 198 8 traditional traditional JJ cord-022053-idft1p6d 198 9 DNA dna NN cord-022053-idft1p6d 198 10 probes probe NNS cord-022053-idft1p6d 198 11 , , , cord-022053-idft1p6d 198 12 such such JJ cord-022053-idft1p6d 198 13 as as IN cord-022053-idft1p6d 198 14 increased increase VBN cord-022053-idft1p6d 198 15 stability stability NN cord-022053-idft1p6d 198 16 and and CC cord-022053-idft1p6d 198 17 ability ability NN cord-022053-idft1p6d 198 18 to to TO cord-022053-idft1p6d 198 19 penetrate penetrate VB cord-022053-idft1p6d 198 20 the the DT cord-022053-idft1p6d 198 21 bacterial bacterial JJ cord-022053-idft1p6d 198 22 cell cell NN cord-022053-idft1p6d 198 23 wall wall NN cord-022053-idft1p6d 198 24 . . . cord-022053-idft1p6d 199 1 Fluorescent fluorescent JJ cord-022053-idft1p6d 199 2 tags tag NNS cord-022053-idft1p6d 199 3 have have VBP cord-022053-idft1p6d 199 4 the the DT cord-022053-idft1p6d 199 5 added add VBN cord-022053-idft1p6d 199 6 advantage advantage NN cord-022053-idft1p6d 199 7 of of IN cord-022053-idft1p6d 199 8 allowing allow VBG cord-022053-idft1p6d 199 9 for for IN cord-022053-idft1p6d 199 10 multicolor multicolor JJ cord-022053-idft1p6d 199 11 detection detection NN cord-022053-idft1p6d 199 12 and and CC cord-022053-idft1p6d 199 13 the the DT cord-022053-idft1p6d 199 14 creation creation NN cord-022053-idft1p6d 199 15 of of IN cord-022053-idft1p6d 199 16 limited limited JJ cord-022053-idft1p6d 199 17 panels panel NNS cord-022053-idft1p6d 199 18 . . . cord-022053-idft1p6d 200 1 These these DT cord-022053-idft1p6d 200 2 are be VBP cord-022053-idft1p6d 200 3 rapid rapid JJ cord-022053-idft1p6d 200 4 assays assay NNS cord-022053-idft1p6d 200 5 ( ( -LRB- cord-022053-idft1p6d 200 6 less less JJR cord-022053-idft1p6d 200 7 than than IN cord-022053-idft1p6d 200 8 1 1 CD cord-022053-idft1p6d 200 9 hour hour NN cord-022053-idft1p6d 200 10 ) ) -RRB- cord-022053-idft1p6d 200 11 and and CC cord-022053-idft1p6d 200 12 are be VBP cord-022053-idft1p6d 200 13 mostly mostly RB cord-022053-idft1p6d 200 14 targeted target VBN cord-022053-idft1p6d 200 15 towards towards IN cord-022053-idft1p6d 200 16 rapid rapid JJ cord-022053-idft1p6d 200 17 diagnostics diagnostic NNS cord-022053-idft1p6d 200 18 of of IN cord-022053-idft1p6d 200 19 positive positive JJ cord-022053-idft1p6d 200 20 blood blood NN cord-022053-idft1p6d 200 21 culture culture NN cord-022053-idft1p6d 200 22 bottles bottle NNS cord-022053-idft1p6d 200 23 . . . cord-022053-idft1p6d 201 1 [ [ -LRB- cord-022053-idft1p6d 201 2 51 51 CD cord-022053-idft1p6d 201 3 ] ] -RRB- cord-022053-idft1p6d 201 4 [ [ -LRB- cord-022053-idft1p6d 201 5 52 52 CD cord-022053-idft1p6d 201 6 ] ] -RRB- cord-022053-idft1p6d 202 1 [ [ -LRB- cord-022053-idft1p6d 202 2 53 53 CD cord-022053-idft1p6d 202 3 ] ] -RRB- cord-022053-idft1p6d 202 4 [ [ -LRB- cord-022053-idft1p6d 202 5 54 54 CD cord-022053-idft1p6d 202 6 ] ] -RRB- cord-022053-idft1p6d 203 1 In in IN cord-022053-idft1p6d 203 2 situ situ NN cord-022053-idft1p6d 203 3 hybridization hybridization NN cord-022053-idft1p6d 203 4 ( ( -LRB- cord-022053-idft1p6d 203 5 ISH ISH NNP cord-022053-idft1p6d 203 6 ) ) -RRB- cord-022053-idft1p6d 203 7 of of IN cord-022053-idft1p6d 203 8 Epstein Epstein NNP cord-022053-idft1p6d 203 9 Barr Barr NNP cord-022053-idft1p6d 203 10 encoding encoding NN cord-022053-idft1p6d 203 11 region region NN cord-022053-idft1p6d 203 12 for for IN cord-022053-idft1p6d 203 13 confirmation confirmation NN cord-022053-idft1p6d 203 14 of of IN cord-022053-idft1p6d 203 15 Epstein Epstein NNP cord-022053-idft1p6d 203 16 - - HYPH cord-022053-idft1p6d 203 17 Barr Barr NNP cord-022053-idft1p6d 203 18 virus virus NN cord-022053-idft1p6d 203 19 infection infection NN cord-022053-idft1p6d 203 20 on on IN cord-022053-idft1p6d 203 21 FFPE FFPE NNP cord-022053-idft1p6d 203 22 is be VBZ cord-022053-idft1p6d 203 23 routinely routinely RB cord-022053-idft1p6d 203 24 used use VBN cord-022053-idft1p6d 203 25 in in IN cord-022053-idft1p6d 203 26 cancer cancer NN cord-022053-idft1p6d 203 27 diagnostics diagnostic NNS cord-022053-idft1p6d 203 28 , , , cord-022053-idft1p6d 203 29 but but CC cord-022053-idft1p6d 203 30 few few JJ cord-022053-idft1p6d 203 31 , , , cord-022053-idft1p6d 203 32 if if IN cord-022053-idft1p6d 203 33 any any DT cord-022053-idft1p6d 203 34 , , , cord-022053-idft1p6d 203 35 other other JJ cord-022053-idft1p6d 203 36 common common JJ cord-022053-idft1p6d 203 37 viral viral JJ cord-022053-idft1p6d 203 38 infections infection NNS cord-022053-idft1p6d 203 39 are be VBP cord-022053-idft1p6d 203 40 confirmed confirm VBN cord-022053-idft1p6d 203 41 this this DT cord-022053-idft1p6d 203 42 way way NN cord-022053-idft1p6d 203 43 , , , cord-022053-idft1p6d 203 44 with with IN cord-022053-idft1p6d 203 45 IHC IHC NNP cord-022053-idft1p6d 203 46 being be VBG cord-022053-idft1p6d 203 47 preferred prefer VBN cord-022053-idft1p6d 203 48 . . . cord-022053-idft1p6d 204 1 Application Application NNP cord-022053-idft1p6d 204 2 of of IN cord-022053-idft1p6d 204 3 RNA RNA NNP cord-022053-idft1p6d 204 4 - - HYPH cord-022053-idft1p6d 204 5 ISH ISH NNP cord-022053-idft1p6d 204 6 to to IN cord-022053-idft1p6d 204 7 Aspergillus aspergillus NN cord-022053-idft1p6d 204 8 and and CC cord-022053-idft1p6d 204 9 Candida Candida NNP cord-022053-idft1p6d 204 10 in in IN cord-022053-idft1p6d 204 11 FFPE FFPE NNP cord-022053-idft1p6d 204 12 showed show VBD cord-022053-idft1p6d 204 13 less less JJR cord-022053-idft1p6d 204 14 sensitivity sensitivity NN cord-022053-idft1p6d 204 15 than than IN cord-022053-idft1p6d 204 16 real real JJ cord-022053-idft1p6d 204 17 - - HYPH cord-022053-idft1p6d 204 18 time time NN cord-022053-idft1p6d 204 19 PCR pcr NN cord-022053-idft1p6d 204 20 with with IN cord-022053-idft1p6d 204 21 sequencing sequencing NN cord-022053-idft1p6d 204 22 ( ( -LRB- cord-022053-idft1p6d 204 23 gold gold NN cord-022053-idft1p6d 204 24 standard standard NN cord-022053-idft1p6d 204 25 ) ) -RRB- cord-022053-idft1p6d 204 26 , , , cord-022053-idft1p6d 204 27 although although IN cord-022053-idft1p6d 204 28 some some DT cord-022053-idft1p6d 204 29 FISH fish NN cord-022053-idft1p6d 204 30 - - HYPH cord-022053-idft1p6d 204 31 positive positive JJ cord-022053-idft1p6d 204 32 , , , cord-022053-idft1p6d 204 33 PCRnegative pcrnegative JJ cord-022053-idft1p6d 204 34 cases case NNS cord-022053-idft1p6d 204 35 with with IN cord-022053-idft1p6d 204 36 obvious obvious JJ cord-022053-idft1p6d 204 37 fungal fungal JJ cord-022053-idft1p6d 204 38 elements element NNS cord-022053-idft1p6d 204 39 were be VBD cord-022053-idft1p6d 204 40 seen see VBN cord-022053-idft1p6d 204 41 , , , cord-022053-idft1p6d 204 42 suggesting suggest VBG cord-022053-idft1p6d 204 43 refinements refinement NNS cord-022053-idft1p6d 204 44 of of IN cord-022053-idft1p6d 204 45 this this DT cord-022053-idft1p6d 204 46 technique technique NN cord-022053-idft1p6d 204 47 may may MD cord-022053-idft1p6d 204 48 be be VB cord-022053-idft1p6d 204 49 valuable valuable JJ cord-022053-idft1p6d 204 50 for for IN cord-022053-idft1p6d 204 51 rapid rapid JJ cord-022053-idft1p6d 204 52 identification identification NN cord-022053-idft1p6d 204 53 of of IN cord-022053-idft1p6d 204 54 these these DT cord-022053-idft1p6d 204 55 common common JJ cord-022053-idft1p6d 204 56 organisms organism NNS cord-022053-idft1p6d 204 57 , , , cord-022053-idft1p6d 204 58 especially especially RB cord-022053-idft1p6d 204 59 if if IN cord-022053-idft1p6d 204 60 mucormycosis mucormycosis NN cord-022053-idft1p6d 204 61 is be VBZ cord-022053-idft1p6d 204 62 in in IN cord-022053-idft1p6d 204 63 the the DT cord-022053-idft1p6d 204 64 differential differential NN cord-022053-idft1p6d 204 65 . . . cord-022053-idft1p6d 205 1 55 55 CD cord-022053-idft1p6d 206 1 A a DT cord-022053-idft1p6d 206 2 unique unique JJ cord-022053-idft1p6d 206 3 probe probe NN cord-022053-idft1p6d 206 4 - - HYPH cord-022053-idft1p6d 206 5 based base VBN cord-022053-idft1p6d 206 6 approached approach VBD cord-022053-idft1p6d 206 7 to to IN cord-022053-idft1p6d 206 8 nucleic nucleic JJ cord-022053-idft1p6d 206 9 acid acid NN cord-022053-idft1p6d 206 10 detection detection NN cord-022053-idft1p6d 206 11 is be VBZ cord-022053-idft1p6d 206 12 the the DT cord-022053-idft1p6d 206 13 RNA RNA NNP cord-022053-idft1p6d 206 14 hybridization hybridization NN cord-022053-idft1p6d 206 15 and and CC cord-022053-idft1p6d 206 16 digital digital JJ cord-022053-idft1p6d 206 17 counting counting NN cord-022053-idft1p6d 206 18 technology technology NN cord-022053-idft1p6d 206 19 offered offer VBN cord-022053-idft1p6d 206 20 by by IN cord-022053-idft1p6d 206 21 NanoString NanoString NNP cord-022053-idft1p6d 206 22 ( ( -LRB- cord-022053-idft1p6d 206 23 Seattle Seattle NNP cord-022053-idft1p6d 206 24 , , , cord-022053-idft1p6d 206 25 Washington Washington NNP cord-022053-idft1p6d 206 26 ) ) -RRB- cord-022053-idft1p6d 206 27 . . . cord-022053-idft1p6d 207 1 This this DT cord-022053-idft1p6d 207 2 method method NN cord-022053-idft1p6d 207 3 uses use VBZ cord-022053-idft1p6d 207 4 a a DT cord-022053-idft1p6d 207 5 capture capture NN cord-022053-idft1p6d 207 6 probe probe NN cord-022053-idft1p6d 207 7 ( ( -LRB- cord-022053-idft1p6d 207 8 usually usually RB cord-022053-idft1p6d 207 9 a a DT cord-022053-idft1p6d 207 10 specific specific JJ cord-022053-idft1p6d 207 11 50-mer 50-mer CD cord-022053-idft1p6d 207 12 ) ) -RRB- cord-022053-idft1p6d 207 13 and and CC cord-022053-idft1p6d 207 14 a a DT cord-022053-idft1p6d 207 15 reporter reporter NN cord-022053-idft1p6d 207 16 probe probe NN cord-022053-idft1p6d 207 17 ( ( -LRB- cord-022053-idft1p6d 207 18 a a DT cord-022053-idft1p6d 207 19 second second JJ cord-022053-idft1p6d 207 20 , , , cord-022053-idft1p6d 207 21 adjacent adjacent JJ cord-022053-idft1p6d 207 22 , , , cord-022053-idft1p6d 207 23 specific specific JJ cord-022053-idft1p6d 207 24 50-mer 50-mer CD cord-022053-idft1p6d 207 25 attached attach VBN cord-022053-idft1p6d 207 26 to to IN cord-022053-idft1p6d 207 27 a a DT cord-022053-idft1p6d 207 28 unique unique JJ cord-022053-idft1p6d 207 29 molecular molecular JJ cord-022053-idft1p6d 207 30 color color NN cord-022053-idft1p6d 207 31 barcode barcode NN cord-022053-idft1p6d 207 32 ) ) -RRB- cord-022053-idft1p6d 207 33 to to TO cord-022053-idft1p6d 207 34 bind bind VB cord-022053-idft1p6d 207 35 up up RP cord-022053-idft1p6d 207 36 individual individual JJ cord-022053-idft1p6d 207 37 molecules molecule NNS cord-022053-idft1p6d 207 38 of of IN cord-022053-idft1p6d 207 39 RNA RNA NNP cord-022053-idft1p6d 207 40 in in IN cord-022053-idft1p6d 207 41 a a DT cord-022053-idft1p6d 207 42 sample sample NN cord-022053-idft1p6d 207 43 , , , cord-022053-idft1p6d 207 44 capture capture VB cord-022053-idft1p6d 207 45 them -PRON- PRP cord-022053-idft1p6d 207 46 on on IN cord-022053-idft1p6d 207 47 a a DT cord-022053-idft1p6d 207 48 solid solid JJ cord-022053-idft1p6d 207 49 state state NN cord-022053-idft1p6d 207 50 matrix matrix NN cord-022053-idft1p6d 207 51 , , , cord-022053-idft1p6d 207 52 and and CC cord-022053-idft1p6d 207 53 use use VB cord-022053-idft1p6d 207 54 digital digital JJ cord-022053-idft1p6d 207 55 imaging imaging NN cord-022053-idft1p6d 207 56 to to TO cord-022053-idft1p6d 207 57 count count VB cord-022053-idft1p6d 207 58 the the DT cord-022053-idft1p6d 207 59 barcodes barcode NNS cord-022053-idft1p6d 207 60 in in IN cord-022053-idft1p6d 207 61 the the DT cord-022053-idft1p6d 207 62 sample sample NN cord-022053-idft1p6d 207 63 . . . cord-022053-idft1p6d 208 1 The the DT cord-022053-idft1p6d 208 2 current current JJ cord-022053-idft1p6d 208 3 version version NN cord-022053-idft1p6d 208 4 can can MD cord-022053-idft1p6d 208 5 measure measure VB cord-022053-idft1p6d 208 6 up up RP cord-022053-idft1p6d 208 7 to to TO cord-022053-idft1p6d 208 8 500 500 CD cord-022053-idft1p6d 208 9 independent independent JJ cord-022053-idft1p6d 208 10 capture capture NN cord-022053-idft1p6d 208 11 : : : cord-022053-idft1p6d 208 12 reporter reporter NN cord-022053-idft1p6d 208 13 pairs pair NNS cord-022053-idft1p6d 208 14 . . . cord-022053-idft1p6d 209 1 The the DT cord-022053-idft1p6d 209 2 technology technology NN cord-022053-idft1p6d 209 3 can can MD cord-022053-idft1p6d 209 4 be be VB cord-022053-idft1p6d 209 5 applied apply VBN cord-022053-idft1p6d 209 6 to to IN cord-022053-idft1p6d 209 7 any any DT cord-022053-idft1p6d 209 8 RNA RNA NNP cord-022053-idft1p6d 209 9 target target NN cord-022053-idft1p6d 209 10 ( ( -LRB- cord-022053-idft1p6d 209 11 human human JJ cord-022053-idft1p6d 209 12 or or CC cord-022053-idft1p6d 209 13 microbial microbial JJ cord-022053-idft1p6d 209 14 ) ) -RRB- cord-022053-idft1p6d 209 15 , , , cord-022053-idft1p6d 209 16 and and CC cord-022053-idft1p6d 209 17 the the DT cord-022053-idft1p6d 209 18 great great JJ cord-022053-idft1p6d 209 19 advantage advantage NN cord-022053-idft1p6d 209 20 in in IN cord-022053-idft1p6d 209 21 infectious infectious JJ cord-022053-idft1p6d 209 22 disease disease NN cord-022053-idft1p6d 209 23 is be VBZ cord-022053-idft1p6d 209 24 the the DT cord-022053-idft1p6d 209 25 extremely extremely RB cord-022053-idft1p6d 209 26 low low JJ cord-022053-idft1p6d 209 27 input input NN cord-022053-idft1p6d 209 28 quantities quantity NNS cord-022053-idft1p6d 209 29 that that WDT cord-022053-idft1p6d 209 30 can can MD cord-022053-idft1p6d 209 31 be be VB cord-022053-idft1p6d 209 32 detected detect VBN cord-022053-idft1p6d 209 33 without without IN cord-022053-idft1p6d 209 34 interference interference NN cord-022053-idft1p6d 209 35 from from IN cord-022053-idft1p6d 209 36 other other JJ cord-022053-idft1p6d 209 37 RNA RNA NNP cord-022053-idft1p6d 209 38 . . . cord-022053-idft1p6d 210 1 Because because IN cord-022053-idft1p6d 210 2 of of IN cord-022053-idft1p6d 210 3 the the DT cord-022053-idft1p6d 210 4 counting counting NN cord-022053-idft1p6d 210 5 algorithm algorithm NN cord-022053-idft1p6d 210 6 , , , cord-022053-idft1p6d 210 7 with with IN cord-022053-idft1p6d 210 8 proper proper JJ cord-022053-idft1p6d 210 9 probe probe NN cord-022053-idft1p6d 210 10 selection selection NN cord-022053-idft1p6d 210 11 in in IN cord-022053-idft1p6d 210 12 a a DT cord-022053-idft1p6d 210 13 given give VBN cord-022053-idft1p6d 210 14 mixture mixture NN cord-022053-idft1p6d 210 15 , , , cord-022053-idft1p6d 210 16 accurate accurate JJ cord-022053-idft1p6d 210 17 quantification quantification NN cord-022053-idft1p6d 210 18 of of IN cord-022053-idft1p6d 210 19 RNA RNA NNP cord-022053-idft1p6d 210 20 is be VBZ cord-022053-idft1p6d 210 21 possible possible JJ cord-022053-idft1p6d 210 22 without without IN cord-022053-idft1p6d 210 23 amplification amplification NN cord-022053-idft1p6d 210 24 . . . cord-022053-idft1p6d 211 1 One one CD cord-022053-idft1p6d 211 2 pitfall pitfall NN cord-022053-idft1p6d 211 3 to to IN cord-022053-idft1p6d 211 4 this this DT cord-022053-idft1p6d 211 5 technology technology NN cord-022053-idft1p6d 211 6 is be VBZ cord-022053-idft1p6d 211 7 that that IN cord-022053-idft1p6d 211 8 the the DT cord-022053-idft1p6d 211 9 presence presence NN cord-022053-idft1p6d 211 10 of of IN cord-022053-idft1p6d 211 11 any any DT cord-022053-idft1p6d 211 12 given give VBN cord-022053-idft1p6d 211 13 target target NN cord-022053-idft1p6d 211 14 in in IN cord-022053-idft1p6d 211 15 a a DT cord-022053-idft1p6d 211 16 disproportionate disproportionate JJ cord-022053-idft1p6d 211 17 ratio ratio NN cord-022053-idft1p6d 211 18 to to IN cord-022053-idft1p6d 211 19 other other JJ cord-022053-idft1p6d 211 20 targets target NNS cord-022053-idft1p6d 211 21 will will MD cord-022053-idft1p6d 211 22 flood flood VB cord-022053-idft1p6d 211 23 the the DT cord-022053-idft1p6d 211 24 digital digital JJ cord-022053-idft1p6d 211 25 analysis analysis NN cord-022053-idft1p6d 211 26 ( ( -LRB- cord-022053-idft1p6d 211 27 i.e. i.e. FW cord-022053-idft1p6d 211 28 , , , cord-022053-idft1p6d 211 29 consider consider VB cord-022053-idft1p6d 211 30 hemoglobin hemoglobin NN cord-022053-idft1p6d 211 31 relative relative JJ cord-022053-idft1p6d 211 32 to to IN cord-022053-idft1p6d 211 33 cytokines cytokine NNS cord-022053-idft1p6d 211 34 in in IN cord-022053-idft1p6d 211 35 peripheral peripheral JJ cord-022053-idft1p6d 211 36 blood blood NN cord-022053-idft1p6d 211 37 ) ) -RRB- cord-022053-idft1p6d 211 38 . . . cord-022053-idft1p6d 212 1 Relative relative JJ cord-022053-idft1p6d 212 2 to to IN cord-022053-idft1p6d 212 3 sequencing sequencing NN cord-022053-idft1p6d 212 4 , , , cord-022053-idft1p6d 212 5 the the DT cord-022053-idft1p6d 212 6 technology technology NN cord-022053-idft1p6d 212 7 remains remain VBZ cord-022053-idft1p6d 212 8 expensive expensive JJ cord-022053-idft1p6d 212 9 , , , cord-022053-idft1p6d 212 10 but but CC cord-022053-idft1p6d 212 11 the the DT cord-022053-idft1p6d 212 12 benefit benefit NN cord-022053-idft1p6d 212 13 of of IN cord-022053-idft1p6d 212 14 quantification quantification NN cord-022053-idft1p6d 212 15 of of IN cord-022053-idft1p6d 212 16 extremely extremely RB cord-022053-idft1p6d 212 17 limited limited JJ cord-022053-idft1p6d 212 18 sample sample NN cord-022053-idft1p6d 212 19 with with IN cord-022053-idft1p6d 212 20 minimal minimal JJ cord-022053-idft1p6d 212 21 processing processing NN cord-022053-idft1p6d 212 22 makes make VBZ cord-022053-idft1p6d 212 23 this this DT cord-022053-idft1p6d 212 24 an an DT cord-022053-idft1p6d 212 25 attractive attractive JJ cord-022053-idft1p6d 212 26 target target NN cord-022053-idft1p6d 212 27 for for IN cord-022053-idft1p6d 212 28 future future JJ cord-022053-idft1p6d 212 29 test test NN cord-022053-idft1p6d 212 30 development development NN cord-022053-idft1p6d 212 31 . . . cord-022053-idft1p6d 213 1 For for IN cord-022053-idft1p6d 213 2 microorganisms microorganism NNS cord-022053-idft1p6d 213 3 , , , cord-022053-idft1p6d 213 4 broad broad JJ cord-022053-idft1p6d 213 5 panels panel NNS cord-022053-idft1p6d 213 6 using use VBG cord-022053-idft1p6d 213 7 signature signature NN cord-022053-idft1p6d 213 8 genes gene NNS cord-022053-idft1p6d 214 1 and/or and/or CC cord-022053-idft1p6d 214 2 focused focused JJ cord-022053-idft1p6d 214 3 panels panel NNS cord-022053-idft1p6d 214 4 using use VBG cord-022053-idft1p6d 214 5 genes gene NNS cord-022053-idft1p6d 214 6 in in IN cord-022053-idft1p6d 214 7 antibiotic antibiotic JJ cord-022053-idft1p6d 214 8 metabolism metabolism NN cord-022053-idft1p6d 214 9 pathways pathway NNS cord-022053-idft1p6d 214 10 can can MD cord-022053-idft1p6d 214 11 be be VB cord-022053-idft1p6d 214 12 created create VBN cord-022053-idft1p6d 214 13 . . . cord-022053-idft1p6d 215 1 Studies study NNS cord-022053-idft1p6d 215 2 in in IN cord-022053-idft1p6d 215 3 a a DT cord-022053-idft1p6d 215 4 range range NN cord-022053-idft1p6d 215 5 of of IN cord-022053-idft1p6d 215 6 diseases disease NNS cord-022053-idft1p6d 215 7 have have VBP cord-022053-idft1p6d 215 8 shown show VBN cord-022053-idft1p6d 215 9 that that IN cord-022053-idft1p6d 215 10 RNA RNA NNP cord-022053-idft1p6d 215 11 from from IN cord-022053-idft1p6d 215 12 any any DT cord-022053-idft1p6d 215 13 source source NN cord-022053-idft1p6d 215 14 , , , cord-022053-idft1p6d 215 15 including include VBG cord-022053-idft1p6d 215 16 FFPE FFPE NNP cord-022053-idft1p6d 215 17 , , , cord-022053-idft1p6d 215 18 is be VBZ cord-022053-idft1p6d 215 19 sufficient sufficient JJ cord-022053-idft1p6d 215 20 for for IN cord-022053-idft1p6d 215 21 NanoString NanoString NNP cord-022053-idft1p6d 215 22 analysis analysis NN cord-022053-idft1p6d 215 23 , , , cord-022053-idft1p6d 215 24 [ [ -LRB- cord-022053-idft1p6d 215 25 56 56 CD cord-022053-idft1p6d 215 26 ] ] -RRB- cord-022053-idft1p6d 215 27 [ [ -LRB- cord-022053-idft1p6d 215 28 57 57 CD cord-022053-idft1p6d 215 29 ] ] -RRB- cord-022053-idft1p6d 215 30 [ [ -LRB- cord-022053-idft1p6d 215 31 58 58 CD cord-022053-idft1p6d 215 32 ] ] -RRB- cord-022053-idft1p6d 216 1 In in IN cord-022053-idft1p6d 216 2 one one CD cord-022053-idft1p6d 216 3 study study NN cord-022053-idft1p6d 216 4 , , , cord-022053-idft1p6d 216 5 quantitative quantitative JJ cord-022053-idft1p6d 216 6 expression expression NN cord-022053-idft1p6d 216 7 of of IN cord-022053-idft1p6d 216 8 Plasmodium Plasmodium NNP cord-022053-idft1p6d 216 9 falciparum falciparum NN cord-022053-idft1p6d 216 10 schizonts schizont NNS cord-022053-idft1p6d 216 11 from from IN cord-022053-idft1p6d 216 12 human human JJ cord-022053-idft1p6d 216 13 tissue tissue NN cord-022053-idft1p6d 216 14 ( ( -LRB- cord-022053-idft1p6d 216 15 both both DT cord-022053-idft1p6d 216 16 frozen frozen JJ cord-022053-idft1p6d 216 17 and and CC cord-022053-idft1p6d 216 18 FFPE FFPE NNP cord-022053-idft1p6d 216 19 ) ) -RRB- cord-022053-idft1p6d 216 20 were be VBD cord-022053-idft1p6d 216 21 measured measure VBN cord-022053-idft1p6d 216 22 and and CC cord-022053-idft1p6d 216 23 , , , cord-022053-idft1p6d 216 24 using use VBG cord-022053-idft1p6d 216 25 imputation imputation NN cord-022053-idft1p6d 216 26 , , , cord-022053-idft1p6d 216 27 the the DT cord-022053-idft1p6d 216 28 entire entire JJ cord-022053-idft1p6d 216 29 expression expression NN cord-022053-idft1p6d 216 30 profile profile NN cord-022053-idft1p6d 216 31 for for IN cord-022053-idft1p6d 216 32 the the DT cord-022053-idft1p6d 216 33 organisms organism NNS cord-022053-idft1p6d 216 34 determined determine VBN cord-022053-idft1p6d 216 35 . . . cord-022053-idft1p6d 217 1 59 59 CD cord-022053-idft1p6d 217 2 pathogens pathogen NNS cord-022053-idft1p6d 217 3 include include VBP cord-022053-idft1p6d 217 4 E. E. NNP cord-022053-idft1p6d 217 5 coli coli NNS cord-022053-idft1p6d 217 6 and and CC cord-022053-idft1p6d 217 7 Shigella Shigella NNP cord-022053-idft1p6d 217 8 , , , cord-022053-idft1p6d 217 9 Salmonella Salmonella NNP cord-022053-idft1p6d 217 10 , , , cord-022053-idft1p6d 217 11 Campylobacter Campylobacter NNP cord-022053-idft1p6d 217 12 , , , cord-022053-idft1p6d 217 13 and and CC cord-022053-idft1p6d 217 14 Clostridium clostridium NN cord-022053-idft1p6d 217 15 perfringens perfringen NNS cord-022053-idft1p6d 217 16 . . . cord-022053-idft1p6d 218 1 Typical typical JJ cord-022053-idft1p6d 218 2 viral viral JJ cord-022053-idft1p6d 218 3 pathogens pathogen NNS cord-022053-idft1p6d 218 4 included include VBN cord-022053-idft1p6d 218 5 in in IN cord-022053-idft1p6d 218 6 these these DT cord-022053-idft1p6d 218 7 panels panel NNS cord-022053-idft1p6d 218 8 are be VBP cord-022053-idft1p6d 218 9 adenovirus adenovirus NN cord-022053-idft1p6d 218 10 , , , cord-022053-idft1p6d 218 11 norovirus norovirus NN cord-022053-idft1p6d 218 12 , , , cord-022053-idft1p6d 218 13 and and CC cord-022053-idft1p6d 218 14 rotavirus rotavirus NN cord-022053-idft1p6d 218 15 , , , cord-022053-idft1p6d 218 16 representing represent VBG cord-022053-idft1p6d 218 17 the the DT cord-022053-idft1p6d 218 18 three three CD cord-022053-idft1p6d 218 19 most most RBS cord-022053-idft1p6d 218 20 common common JJ cord-022053-idft1p6d 218 21 symptomatic symptomatic JJ cord-022053-idft1p6d 218 22 viral viral JJ cord-022053-idft1p6d 218 23 diarrheas diarrhea NNS cord-022053-idft1p6d 218 24 . . . cord-022053-idft1p6d 219 1 Diagnosis diagnosis NN cord-022053-idft1p6d 219 2 is be VBZ cord-022053-idft1p6d 219 3 moving move VBG cord-022053-idft1p6d 219 4 more more JJR cord-022053-idft1p6d 219 5 and and CC cord-022053-idft1p6d 219 6 more more RBR cord-022053-idft1p6d 219 7 towards towards IN cord-022053-idft1p6d 219 8 multiplex multiplex JJ cord-022053-idft1p6d 219 9 panels panel NNS cord-022053-idft1p6d 219 10 that that WDT cord-022053-idft1p6d 219 11 cover cover VBP cord-022053-idft1p6d 219 12 major major JJ cord-022053-idft1p6d 219 13 bacterial bacterial JJ cord-022053-idft1p6d 219 14 pathogens pathogen NNS cord-022053-idft1p6d 219 15 , , , cord-022053-idft1p6d 219 16 as as RB cord-022053-idft1p6d 219 17 well well RB cord-022053-idft1p6d 219 18 as as IN cord-022053-idft1p6d 219 19 some some DT cord-022053-idft1p6d 219 20 parasitic parasitic JJ cord-022053-idft1p6d 219 21 and and CC cord-022053-idft1p6d 219 22 viral viral JJ cord-022053-idft1p6d 219 23 agents agent NNS cord-022053-idft1p6d 219 24 . . . cord-022053-idft1p6d 220 1 [ [ -LRB- cord-022053-idft1p6d 220 2 84 84 CD cord-022053-idft1p6d 220 3 ] ] -RRB- cord-022053-idft1p6d 220 4 [ [ -LRB- cord-022053-idft1p6d 220 5 85 85 CD cord-022053-idft1p6d 220 6 ] ] -RRB- cord-022053-idft1p6d 220 7 [ [ -LRB- cord-022053-idft1p6d 220 8 86 86 CD cord-022053-idft1p6d 220 9 ] ] -RRB- cord-022053-idft1p6d 221 1 In in IN cord-022053-idft1p6d 221 2 addition addition NN cord-022053-idft1p6d 221 3 to to IN cord-022053-idft1p6d 221 4 standard standard JJ cord-022053-idft1p6d 221 5 agents agent NNS cord-022053-idft1p6d 221 6 of of IN cord-022053-idft1p6d 221 7 infectious infectious JJ cord-022053-idft1p6d 221 8 diarrhea diarrhea NN cord-022053-idft1p6d 221 9 , , , cord-022053-idft1p6d 221 10 there there EX cord-022053-idft1p6d 221 11 are be VBP cord-022053-idft1p6d 221 12 special special JJ cord-022053-idft1p6d 221 13 considerations consideration NNS cord-022053-idft1p6d 221 14 when when WRB cord-022053-idft1p6d 221 15 testing test VBG cord-022053-idft1p6d 221 16 for for IN cord-022053-idft1p6d 221 17 disease disease NN cord-022053-idft1p6d 221 18 caused cause VBN cord-022053-idft1p6d 221 19 by by IN cord-022053-idft1p6d 221 20 C. C. NNP cord-022053-idft1p6d 221 21 difficile difficile NNP cord-022053-idft1p6d 221 22 . . . cord-022053-idft1p6d 222 1 These these DT cord-022053-idft1p6d 222 2 panels panel NNS cord-022053-idft1p6d 222 3 are be VBP cord-022053-idft1p6d 222 4 , , , cord-022053-idft1p6d 222 5 again again RB cord-022053-idft1p6d 222 6 , , , cord-022053-idft1p6d 222 7 extremely extremely RB cord-022053-idft1p6d 222 8 valuable valuable JJ cord-022053-idft1p6d 222 9 because because IN cord-022053-idft1p6d 222 10 the the DT cord-022053-idft1p6d 222 11 tools tool NNS cord-022053-idft1p6d 222 12 to to TO cord-022053-idft1p6d 222 13 diagnose diagnose VB cord-022053-idft1p6d 222 14 these these DT cord-022053-idft1p6d 222 15 disease disease NN cord-022053-idft1p6d 222 16 in in IN cord-022053-idft1p6d 222 17 anatomic anatomic JJ cord-022053-idft1p6d 222 18 pathology pathology NN cord-022053-idft1p6d 222 19 are be VBP cord-022053-idft1p6d 222 20 often often RB cord-022053-idft1p6d 222 21 very very RB cord-022053-idft1p6d 222 22 limited limited JJ cord-022053-idft1p6d 222 23 and and CC cord-022053-idft1p6d 222 24 too too RB cord-022053-idft1p6d 222 25 invasive invasive JJ cord-022053-idft1p6d 222 26 for for IN cord-022053-idft1p6d 222 27 most most JJS cord-022053-idft1p6d 222 28 patient patient JJ cord-022053-idft1p6d 222 29 situations situation NNS cord-022053-idft1p6d 222 30 . . . cord-022053-idft1p6d 223 1 Parasitic parasitic JJ cord-022053-idft1p6d 223 2 enteric enteric JJ cord-022053-idft1p6d 223 3 infections infection NNS cord-022053-idft1p6d 223 4 represent represent VBP cord-022053-idft1p6d 223 5 a a DT cord-022053-idft1p6d 223 6 major major JJ cord-022053-idft1p6d 223 7 challenge challenge NN cord-022053-idft1p6d 223 8 in in IN cord-022053-idft1p6d 223 9 developing develop VBG cord-022053-idft1p6d 223 10 countries country NNS cord-022053-idft1p6d 223 11 but but CC cord-022053-idft1p6d 223 12 remain remain VBP cord-022053-idft1p6d 223 13 rare rare JJ cord-022053-idft1p6d 223 14 in in IN cord-022053-idft1p6d 223 15 countries country NNS cord-022053-idft1p6d 223 16 in in IN cord-022053-idft1p6d 223 17 which which WDT cord-022053-idft1p6d 223 18 most most JJS cord-022053-idft1p6d 223 19 new new JJ cord-022053-idft1p6d 223 20 technologies technology NNS cord-022053-idft1p6d 223 21 are be VBP cord-022053-idft1p6d 223 22 being be VBG cord-022053-idft1p6d 223 23 developed develop VBN cord-022053-idft1p6d 223 24 . . . cord-022053-idft1p6d 224 1 Despite despite IN cord-022053-idft1p6d 224 2 this this DT cord-022053-idft1p6d 224 3 disparate disparate JJ cord-022053-idft1p6d 224 4 situation situation NN cord-022053-idft1p6d 224 5 , , , cord-022053-idft1p6d 224 6 efforts effort NNS cord-022053-idft1p6d 224 7 have have VBP cord-022053-idft1p6d 224 8 been be VBN cord-022053-idft1p6d 224 9 made make VBN cord-022053-idft1p6d 224 10 to to TO cord-022053-idft1p6d 224 11 approach approach VB cord-022053-idft1p6d 224 12 parasitic parasitic JJ cord-022053-idft1p6d 224 13 infections infection NNS cord-022053-idft1p6d 224 14 , , , cord-022053-idft1p6d 224 15 and and CC cord-022053-idft1p6d 224 16 thus thus RB cord-022053-idft1p6d 224 17 the the DT cord-022053-idft1p6d 224 18 inherent inherent JJ cord-022053-idft1p6d 224 19 challenges challenge NNS cord-022053-idft1p6d 224 20 have have VBP cord-022053-idft1p6d 224 21 become become VBN cord-022053-idft1p6d 224 22 apparent apparent JJ cord-022053-idft1p6d 224 23 . . . cord-022053-idft1p6d 225 1 Extraction extraction NN cord-022053-idft1p6d 225 2 from from IN cord-022053-idft1p6d 225 3 stool stool NN cord-022053-idft1p6d 225 4 for for IN cord-022053-idft1p6d 225 5 suspected suspect VBN cord-022053-idft1p6d 225 6 parasite parasite NN cord-022053-idft1p6d 225 7 infections infection NNS cord-022053-idft1p6d 225 8 requires require VBZ cord-022053-idft1p6d 225 9 that that IN cord-022053-idft1p6d 225 10 protists protist NNS cord-022053-idft1p6d 225 11 ( ( -LRB- cord-022053-idft1p6d 225 12 ciliates ciliate NNS cord-022053-idft1p6d 225 13 , , , cord-022053-idft1p6d 225 14 ameoba ameoba NN cord-022053-idft1p6d 225 15 , , , cord-022053-idft1p6d 225 16 flagellates flagellate NNS cord-022053-idft1p6d 225 17 , , , cord-022053-idft1p6d 225 18 coccidia coccidia NN cord-022053-idft1p6d 225 19 ) ) -RRB- cord-022053-idft1p6d 225 20 , , , cord-022053-idft1p6d 225 21 helminth helminth JJ cord-022053-idft1p6d 225 22 larvae larva NNS cord-022053-idft1p6d 225 23 ( ( -LRB- cord-022053-idft1p6d 225 24 nematodes nematode NNS cord-022053-idft1p6d 225 25 ) ) -RRB- cord-022053-idft1p6d 225 26 , , , cord-022053-idft1p6d 225 27 and and CC cord-022053-idft1p6d 225 28 helminth helminth JJ cord-022053-idft1p6d 225 29 eggs egg NNS cord-022053-idft1p6d 225 30 ( ( -LRB- cord-022053-idft1p6d 225 31 nematode nematode NN cord-022053-idft1p6d 225 32 , , , cord-022053-idft1p6d 225 33 trematode trematode NN cord-022053-idft1p6d 225 34 , , , cord-022053-idft1p6d 225 35 and and CC cord-022053-idft1p6d 225 36 cestode cestode NNP cord-022053-idft1p6d 225 37 ) ) -RRB- cord-022053-idft1p6d 225 38 be be VB cord-022053-idft1p6d 225 39 lysed lyse VBN cord-022053-idft1p6d 225 40 sufficiently sufficiently RB cord-022053-idft1p6d 225 41 to to TO cord-022053-idft1p6d 225 42 release release VB cord-022053-idft1p6d 225 43 DNA dna NN cord-022053-idft1p6d 225 44 efficiently efficiently RB cord-022053-idft1p6d 225 45 . . . cord-022053-idft1p6d 226 1 This this DT cord-022053-idft1p6d 226 2 challenge challenge NN cord-022053-idft1p6d 226 3 has have VBZ cord-022053-idft1p6d 226 4 led lead VBN cord-022053-idft1p6d 226 5 to to IN cord-022053-idft1p6d 226 6 eight eight CD cord-022053-idft1p6d 226 7 or or CC cord-022053-idft1p6d 226 8 more more JJR cord-022053-idft1p6d 226 9 different different JJ cord-022053-idft1p6d 226 10 extraction extraction NN cord-022053-idft1p6d 226 11 protocols protocol NNS cord-022053-idft1p6d 226 12 with with IN cord-022053-idft1p6d 226 13 a a DT cord-022053-idft1p6d 226 14 range range NN cord-022053-idft1p6d 226 15 of of IN cord-022053-idft1p6d 226 16 preparation preparation NN cord-022053-idft1p6d 226 17 requirements requirement NNS cord-022053-idft1p6d 226 18 , , , cord-022053-idft1p6d 226 19 including include VBG cord-022053-idft1p6d 226 20 spin spin NN cord-022053-idft1p6d 226 21 columns column NNS cord-022053-idft1p6d 226 22 , , , cord-022053-idft1p6d 226 23 automated automate VBN cord-022053-idft1p6d 226 24 magnetic magnetic JJ cord-022053-idft1p6d 226 25 bead bead NN cord-022053-idft1p6d 226 26 assays assay NNS cord-022053-idft1p6d 226 27 , , , cord-022053-idft1p6d 226 28 and and CC cord-022053-idft1p6d 226 29 " " `` cord-022053-idft1p6d 226 30 bead bead NN cord-022053-idft1p6d 226 31 beating beat VBG cord-022053-idft1p6d 226 32 " " '' cord-022053-idft1p6d 226 33 methods method NNS cord-022053-idft1p6d 226 34 . . . cord-022053-idft1p6d 227 1 Molecular molecular JJ cord-022053-idft1p6d 227 2 targets target NNS cord-022053-idft1p6d 227 3 for for IN cord-022053-idft1p6d 227 4 subsequent subsequent JJ cord-022053-idft1p6d 227 5 detection detection NN cord-022053-idft1p6d 227 6 assays assay NNS cord-022053-idft1p6d 227 7 as as IN cord-022053-idft1p6d 227 8 specific specific JJ cord-022053-idft1p6d 227 9 single single JJ cord-022053-idft1p6d 227 10 targets target NNS cord-022053-idft1p6d 227 11 across across IN cord-022053-idft1p6d 227 12 this this DT cord-022053-idft1p6d 227 13 range range NN cord-022053-idft1p6d 227 14 of of IN cord-022053-idft1p6d 227 15 organisms organism NNS cord-022053-idft1p6d 227 16 has have VBZ cord-022053-idft1p6d 227 17 included include VBN cord-022053-idft1p6d 227 18 18S 18S NNP cord-022053-idft1p6d 227 19 rDNA rDNA NNP cord-022053-idft1p6d 227 20 , , , cord-022053-idft1p6d 227 21 ITS ITS NNP cord-022053-idft1p6d 227 22 , , , cord-022053-idft1p6d 227 23 COX COX NNP cord-022053-idft1p6d 227 24 1 1 CD cord-022053-idft1p6d 227 25 , , , cord-022053-idft1p6d 227 26 pOV-46 pov-46 NN cord-022053-idft1p6d 227 27 , , , cord-022053-idft1p6d 227 28 5.8S 5.8s NN cord-022053-idft1p6d 227 29 rDNA rdna NN cord-022053-idft1p6d 227 30 , , , cord-022053-idft1p6d 227 31 Segment Segment NNP cord-022053-idft1p6d 227 32 A A NNP cord-022053-idft1p6d 227 33 , , , cord-022053-idft1p6d 227 34 COWP COWP NNP cord-022053-idft1p6d 227 35 , , , cord-022053-idft1p6d 227 36 actin actin NN cord-022053-idft1p6d 227 37 , , , cord-022053-idft1p6d 227 38 HDP2 HDP2 NNPS cord-022053-idft1p6d 227 39 , , , cord-022053-idft1p6d 227 40 DL1 DL1 NNP cord-022053-idft1p6d 227 41 , , , cord-022053-idft1p6d 227 42 and and CC cord-022053-idft1p6d 227 43 28S 28S NNP cord-022053-idft1p6d 227 44 rDNA rDNA NNP cord-022053-idft1p6d 227 45 . . . cord-022053-idft1p6d 227 46 87 87 CD cord-022053-idft1p6d 228 1 In in IN cord-022053-idft1p6d 228 2 commercially commercially RB cord-022053-idft1p6d 228 3 available available JJ cord-022053-idft1p6d 228 4 , , , cord-022053-idft1p6d 228 5 multiplex multiplex JJ cord-022053-idft1p6d 228 6 PCR pcr NN cord-022053-idft1p6d 228 7 assays assay NNS cord-022053-idft1p6d 228 8 , , , cord-022053-idft1p6d 228 9 the the DT cord-022053-idft1p6d 228 10 majority majority NN cord-022053-idft1p6d 228 11 of of IN cord-022053-idft1p6d 228 12 the the DT cord-022053-idft1p6d 228 13 platforms platform NNS cord-022053-idft1p6d 228 14 target target VB cord-022053-idft1p6d 228 15 only only RB cord-022053-idft1p6d 228 16 Cryptosporidium cryptosporidium NN cord-022053-idft1p6d 228 17 , , , cord-022053-idft1p6d 228 18 Giardia Giardia NNP cord-022053-idft1p6d 228 19 , , , cord-022053-idft1p6d 228 20 Entamoeba Entamoeba NNP cord-022053-idft1p6d 228 21 histolytica histolytica NNP cord-022053-idft1p6d 228 22 , , , cord-022053-idft1p6d 228 23 and and CC cord-022053-idft1p6d 228 24 , , , cord-022053-idft1p6d 228 25 rarely rarely RB cord-022053-idft1p6d 228 26 , , , cord-022053-idft1p6d 228 27 Cyclospora Cyclospora NNP cord-022053-idft1p6d 228 28 . . . cord-022053-idft1p6d 229 1 Because because IN cord-022053-idft1p6d 229 2 these these DT cord-022053-idft1p6d 229 3 first first JJ cord-022053-idft1p6d 229 4 three three CD cord-022053-idft1p6d 229 5 represent represent VBP cord-022053-idft1p6d 229 6 80 80 CD cord-022053-idft1p6d 229 7 % % NN cord-022053-idft1p6d 229 8 to to TO cord-022053-idft1p6d 229 9 99 99 CD cord-022053-idft1p6d 229 10 % % NN cord-022053-idft1p6d 229 11 of of IN cord-022053-idft1p6d 229 12 parasites parasite NNS cord-022053-idft1p6d 229 13 isolated isolate VBN cord-022053-idft1p6d 229 14 by by IN cord-022053-idft1p6d 229 15 all all DT cord-022053-idft1p6d 229 16 methods method NNS cord-022053-idft1p6d 229 17 from from IN cord-022053-idft1p6d 229 18 stool stool NN cord-022053-idft1p6d 229 19 in in IN cord-022053-idft1p6d 229 20 developed develop VBN cord-022053-idft1p6d 229 21 nations nation NNS cord-022053-idft1p6d 229 22 , , , cord-022053-idft1p6d 229 23 additions addition NNS cord-022053-idft1p6d 229 24 of of IN cord-022053-idft1p6d 229 25 other other JJ cord-022053-idft1p6d 229 26 much much RB cord-022053-idft1p6d 229 27 less less JJR cord-022053-idft1p6d 229 28 common common JJ cord-022053-idft1p6d 229 29 pathogens pathogen NNS cord-022053-idft1p6d 229 30 is be VBZ cord-022053-idft1p6d 229 31 not not RB cord-022053-idft1p6d 229 32 common common JJ cord-022053-idft1p6d 229 33 . . . cord-022053-idft1p6d 230 1 Inclusion inclusion NN cord-022053-idft1p6d 230 2 of of IN cord-022053-idft1p6d 230 3 nonpathogenic nonpathogenic NNP cord-022053-idft1p6d 230 4 ameba ameba NNP cord-022053-idft1p6d 230 5 is be VBZ cord-022053-idft1p6d 230 6 common common JJ cord-022053-idft1p6d 230 7 in in IN cord-022053-idft1p6d 230 8 these these DT cord-022053-idft1p6d 230 9 assays assay NNS cord-022053-idft1p6d 230 10 but but CC cord-022053-idft1p6d 230 11 of of IN cord-022053-idft1p6d 230 12 questionable questionable JJ cord-022053-idft1p6d 230 13 value value NN cord-022053-idft1p6d 230 14 . . . cord-022053-idft1p6d 231 1 Genitourinary genitourinary JJ cord-022053-idft1p6d 231 2 samples sample NNS cord-022053-idft1p6d 231 3 ( ( -LRB- cord-022053-idft1p6d 231 4 fluid fluid NN cord-022053-idft1p6d 231 5 from from IN cord-022053-idft1p6d 231 6 cervical cervical JJ cord-022053-idft1p6d 231 7 samples sample NNS cord-022053-idft1p6d 231 8 , , , cord-022053-idft1p6d 231 9 urethral urethral JJ cord-022053-idft1p6d 231 10 swabs swab NNS cord-022053-idft1p6d 231 11 ) ) -RRB- cord-022053-idft1p6d 231 12 are be VBP cord-022053-idft1p6d 231 13 another another DT cord-022053-idft1p6d 231 14 sample sample NN cord-022053-idft1p6d 231 15 that that WDT cord-022053-idft1p6d 231 16 benefits benefit VBZ cord-022053-idft1p6d 231 17 from from IN cord-022053-idft1p6d 231 18 multiplex multiplex JJ cord-022053-idft1p6d 231 19 testing testing NN cord-022053-idft1p6d 231 20 as as IN cord-022053-idft1p6d 231 21 public public JJ cord-022053-idft1p6d 231 22 health health NN cord-022053-idft1p6d 231 23 screening screening NN cord-022053-idft1p6d 231 24 of of IN cord-022053-idft1p6d 231 25 sexually sexually RB cord-022053-idft1p6d 231 26 transmitted transmit VBN cord-022053-idft1p6d 231 27 diseases disease NNS cord-022053-idft1p6d 231 28 are be VBP cord-022053-idft1p6d 231 29 extremely extremely RB cord-022053-idft1p6d 231 30 valuable valuable JJ cord-022053-idft1p6d 231 31 for for IN cord-022053-idft1p6d 231 32 individual individual JJ cord-022053-idft1p6d 231 33 patient patient NN cord-022053-idft1p6d 231 34 diagnosis diagnosis NN cord-022053-idft1p6d 231 35 , , , cord-022053-idft1p6d 231 36 as as RB cord-022053-idft1p6d 231 37 well well RB cord-022053-idft1p6d 231 38 as as IN cord-022053-idft1p6d 231 39 epidemiologic epidemiologic JJ cord-022053-idft1p6d 231 40 survey survey NN cord-022053-idft1p6d 231 41 , , , cord-022053-idft1p6d 231 42 especially especially RB cord-022053-idft1p6d 231 43 with with IN cord-022053-idft1p6d 231 44 the the DT cord-022053-idft1p6d 231 45 inclusion inclusion NN cord-022053-idft1p6d 231 46 of of IN cord-022053-idft1p6d 231 47 HIV HIV NNP cord-022053-idft1p6d 231 48 . . . cord-022053-idft1p6d 232 1 Neisseria Neisseria NNP cord-022053-idft1p6d 232 2 gonorrhea gonorrhea NN cord-022053-idft1p6d 232 3 , , , cord-022053-idft1p6d 232 4 Chlamydia Chlamydia NNP cord-022053-idft1p6d 232 5 trachomatis trachomatis NN cord-022053-idft1p6d 232 6 , , , cord-022053-idft1p6d 232 7 and and CC cord-022053-idft1p6d 232 8 HPV hpv NN cord-022053-idft1p6d 232 9 in in IN cord-022053-idft1p6d 232 10 the the DT cord-022053-idft1p6d 232 11 Hologic Hologic NNP cord-022053-idft1p6d 232 12 Panther Panther NNP cord-022053-idft1p6d 232 13 system system NN cord-022053-idft1p6d 232 14 can can MD cord-022053-idft1p6d 232 15 be be VB cord-022053-idft1p6d 232 16 performed perform VBN cord-022053-idft1p6d 232 17 on on IN cord-022053-idft1p6d 232 18 a a DT cord-022053-idft1p6d 232 19 single single JJ cord-022053-idft1p6d 232 20 sample sample NN cord-022053-idft1p6d 232 21 , , , cord-022053-idft1p6d 232 22 and and CC cord-022053-idft1p6d 232 23 this this DT cord-022053-idft1p6d 232 24 system system NN cord-022053-idft1p6d 232 25 also also RB cord-022053-idft1p6d 232 26 can can MD cord-022053-idft1p6d 232 27 test test VB cord-022053-idft1p6d 232 28 for for IN cord-022053-idft1p6d 232 29 Trichomonas Trichomonas NNP cord-022053-idft1p6d 232 30 . . . cord-022053-idft1p6d 233 1 The the DT cord-022053-idft1p6d 233 2 FilmArray FilmArray NNP cord-022053-idft1p6d 233 3 from from IN cord-022053-idft1p6d 233 4 BioFire BioFire NNP cord-022053-idft1p6d 233 5 ( ( -LRB- cord-022053-idft1p6d 233 6 Salt Salt NNP cord-022053-idft1p6d 233 7 Lake Lake NNP cord-022053-idft1p6d 233 8 City City NNP cord-022053-idft1p6d 233 9 , , , cord-022053-idft1p6d 233 10 Utah Utah NNP cord-022053-idft1p6d 233 11 ) ) -RRB- cord-022053-idft1p6d 233 12 detects detect VBZ cord-022053-idft1p6d 233 13 Chlamydia Chlamydia NNP cord-022053-idft1p6d 233 14 , , , cord-022053-idft1p6d 233 15 Neisseria Neisseria NNP cord-022053-idft1p6d 233 16 , , , cord-022053-idft1p6d 233 17 syphilis syphili NNS cord-022053-idft1p6d 233 18 , , , cord-022053-idft1p6d 233 19 Trichomonas Trichomonas NNP cord-022053-idft1p6d 233 20 , , , cord-022053-idft1p6d 233 21 Mycoplasma Mycoplasma NNP cord-022053-idft1p6d 233 22 / / SYM cord-022053-idft1p6d 233 23 Ureaplasma Ureaplasma NNP cord-022053-idft1p6d 233 24 , , , cord-022053-idft1p6d 233 25 herpes herpes NN cord-022053-idft1p6d 233 26 simplex simplex NN cord-022053-idft1p6d 233 27 , , , cord-022053-idft1p6d 233 28 and and CC cord-022053-idft1p6d 233 29 chancroid chancroid NN cord-022053-idft1p6d 233 30 in in IN cord-022053-idft1p6d 233 31 a a DT cord-022053-idft1p6d 233 32 single single JJ cord-022053-idft1p6d 233 33 sample sample NN cord-022053-idft1p6d 233 34 . . . cord-022053-idft1p6d 234 1 88 88 CD cord-022053-idft1p6d 235 1 Although although IN cord-022053-idft1p6d 235 2 relatively relatively RB cord-022053-idft1p6d 235 3 uncommon uncommon JJ cord-022053-idft1p6d 235 4 , , , cord-022053-idft1p6d 235 5 meningitis meningitis NN cord-022053-idft1p6d 235 6 and and CC cord-022053-idft1p6d 235 7 encephalitis encephalitis JJ cord-022053-idft1p6d 235 8 ( ( -LRB- cord-022053-idft1p6d 235 9 both both DT cord-022053-idft1p6d 235 10 nosocomial nosocomial JJ cord-022053-idft1p6d 235 11 and and CC cord-022053-idft1p6d 235 12 community community NN cord-022053-idft1p6d 235 13 - - HYPH cord-022053-idft1p6d 235 14 acquired acquire VBN cord-022053-idft1p6d 235 15 ) ) -RRB- cord-022053-idft1p6d 235 16 carry carry VB cord-022053-idft1p6d 235 17 high high JJ cord-022053-idft1p6d 235 18 morbidity morbidity NN cord-022053-idft1p6d 235 19 and and CC cord-022053-idft1p6d 235 20 mortality mortality NN cord-022053-idft1p6d 235 21 . . . cord-022053-idft1p6d 236 1 [ [ -LRB- cord-022053-idft1p6d 236 2 89 89 CD cord-022053-idft1p6d 236 3 ] ] -RRB- cord-022053-idft1p6d 236 4 [ [ -LRB- cord-022053-idft1p6d 236 5 90 90 CD cord-022053-idft1p6d 236 6 ] ] -RRB- cord-022053-idft1p6d 237 1 [ [ -LRB- cord-022053-idft1p6d 237 2 91 91 CD cord-022053-idft1p6d 237 3 ] ] -RRB- cord-022053-idft1p6d 238 1 Time time NN cord-022053-idft1p6d 238 2 is be VBZ cord-022053-idft1p6d 238 3 of of IN cord-022053-idft1p6d 238 4 the the DT cord-022053-idft1p6d 238 5 essence essence NN cord-022053-idft1p6d 238 6 when when WRB cord-022053-idft1p6d 238 7 diagnosing diagnose VBG cord-022053-idft1p6d 238 8 a a DT cord-022053-idft1p6d 238 9 causative causative JJ cord-022053-idft1p6d 238 10 agent agent NN cord-022053-idft1p6d 238 11 , , , cord-022053-idft1p6d 238 12 particularly particularly RB cord-022053-idft1p6d 238 13 when when WRB cord-022053-idft1p6d 238 14 trying try VBG cord-022053-idft1p6d 238 15 to to TO cord-022053-idft1p6d 238 16 determine determine VB cord-022053-idft1p6d 238 17 whether whether IN cord-022053-idft1p6d 238 18 it -PRON- PRP cord-022053-idft1p6d 238 19 is be VBZ cord-022053-idft1p6d 238 20 a a DT cord-022053-idft1p6d 238 21 bacterial bacterial JJ cord-022053-idft1p6d 238 22 pathogen pathogen NN cord-022053-idft1p6d 238 23 that that WDT cord-022053-idft1p6d 238 24 needs need VBZ cord-022053-idft1p6d 238 25 immediate immediate JJ cord-022053-idft1p6d 238 26 antibiotic antibiotic JJ cord-022053-idft1p6d 238 27 coverage coverage NN cord-022053-idft1p6d 238 28 along along IN cord-022053-idft1p6d 238 29 with with IN cord-022053-idft1p6d 238 30 herpes herpes NNP cord-022053-idft1p6d 238 31 simplex simplex NNP cord-022053-idft1p6d 238 32 , , , cord-022053-idft1p6d 238 33 which which WDT cord-022053-idft1p6d 238 34 needs need VBZ cord-022053-idft1p6d 238 35 immediate immediate JJ cord-022053-idft1p6d 238 36 antivirals antiviral NNS cord-022053-idft1p6d 238 37 . . . cord-022053-idft1p6d 239 1 Common common JJ cord-022053-idft1p6d 239 2 bacterial bacterial JJ cord-022053-idft1p6d 239 3 pathogens pathogen NNS cord-022053-idft1p6d 239 4 include include VBP cord-022053-idft1p6d 239 5 S. S. NNP cord-022053-idft1p6d 239 6 pneumoniae pneumoniae NN cord-022053-idft1p6d 239 7 , , , cord-022053-idft1p6d 239 8 Streptococcus Streptococcus NNP cord-022053-idft1p6d 239 9 agalactiae agalactiae NN cord-022053-idft1p6d 239 10 , , , cord-022053-idft1p6d 239 11 Neisseria Neisseria NNP cord-022053-idft1p6d 239 12 meningitidis meningitidis NN cord-022053-idft1p6d 239 13 , , , cord-022053-idft1p6d 239 14 Haemophilus haemophilus JJ cord-022053-idft1p6d 239 15 influenzae influenzae NN cord-022053-idft1p6d 239 16 , , , cord-022053-idft1p6d 239 17 and and CC cord-022053-idft1p6d 239 18 Listeria Listeria NNP cord-022053-idft1p6d 239 19 monocytogenes monocytogene NNS cord-022053-idft1p6d 239 20 , , , cord-022053-idft1p6d 239 21 although although IN cord-022053-idft1p6d 239 22 there there EX cord-022053-idft1p6d 239 23 are be VBP cord-022053-idft1p6d 239 24 also also RB cord-022053-idft1p6d 239 25 several several JJ cord-022053-idft1p6d 239 26 other other JJ cord-022053-idft1p6d 239 27 , , , cord-022053-idft1p6d 239 28 less less RBR cord-022053-idft1p6d 239 29 frequently frequently RB cord-022053-idft1p6d 239 30 isolated isolate VBN cord-022053-idft1p6d 239 31 , , , cord-022053-idft1p6d 239 32 pathogens pathogen NNS cord-022053-idft1p6d 239 33 . . . cord-022053-idft1p6d 240 1 Viral viral JJ cord-022053-idft1p6d 240 2 pathogens pathogen NNS cord-022053-idft1p6d 240 3 in in IN cord-022053-idft1p6d 240 4 these these DT cord-022053-idft1p6d 240 5 panels panel NNS cord-022053-idft1p6d 240 6 include include VBP cord-022053-idft1p6d 240 7 the the DT cord-022053-idft1p6d 240 8 primary primary JJ cord-022053-idft1p6d 240 9 actionable actionable JJ cord-022053-idft1p6d 240 10 viruses virus NNS cord-022053-idft1p6d 240 11 ( ( -LRB- cord-022053-idft1p6d 240 12 Cytomegalovirus Cytomegalovirus NNP cord-022053-idft1p6d 240 13 , , , cord-022053-idft1p6d 240 14 herpes herpes NN cord-022053-idft1p6d 240 15 simplex simplex NN cord-022053-idft1p6d 240 16 , , , cord-022053-idft1p6d 240 17 varicella varicella NN cord-022053-idft1p6d 240 18 zoster zoster NNP cord-022053-idft1p6d 240 19 virus virus NN cord-022053-idft1p6d 240 20 ) ) -RRB- cord-022053-idft1p6d 240 21 , , , cord-022053-idft1p6d 240 22 as as RB cord-022053-idft1p6d 240 23 well well RB cord-022053-idft1p6d 240 24 as as IN cord-022053-idft1p6d 240 25 other other JJ cord-022053-idft1p6d 240 26 common common JJ cord-022053-idft1p6d 240 27 viruses virus NNS cord-022053-idft1p6d 240 28 ( ( -LRB- cord-022053-idft1p6d 240 29 Enterovirus enterovirus NN cord-022053-idft1p6d 240 30 , , , cord-022053-idft1p6d 240 31 Parechovirus Parechovirus NNP cord-022053-idft1p6d 240 32 , , , cord-022053-idft1p6d 240 33 and and CC cord-022053-idft1p6d 240 34 human human JJ cord-022053-idft1p6d 240 35 herpesvirus herpesvirus NN cord-022053-idft1p6d 240 36 ( ( -LRB- cord-022053-idft1p6d 240 37 HHV)-6 HHV)-6 NNP cord-022053-idft1p6d 240 38 ) ) -RRB- cord-022053-idft1p6d 240 39 . . . cord-022053-idft1p6d 241 1 Platforms platform NNS cord-022053-idft1p6d 241 2 also also RB cord-022053-idft1p6d 241 3 may may MD cord-022053-idft1p6d 241 4 include include VB cord-022053-idft1p6d 241 5 Cryptococcus Cryptococcus NNP cord-022053-idft1p6d 241 6 species specie NNS cord-022053-idft1p6d 241 7 of of IN cord-022053-idft1p6d 241 8 fungi fungus NNS cord-022053-idft1p6d 241 9 , , , cord-022053-idft1p6d 241 10 which which WDT cord-022053-idft1p6d 241 11 is be VBZ cord-022053-idft1p6d 241 12 very very RB cord-022053-idft1p6d 241 13 valuable valuable JJ cord-022053-idft1p6d 241 14 in in IN cord-022053-idft1p6d 241 15 immunosuppressed immunosuppressed JJ cord-022053-idft1p6d 241 16 populations population NNS cord-022053-idft1p6d 241 17 . . . cord-022053-idft1p6d 242 1 92 92 CD cord-022053-idft1p6d 242 2 Current current JJ cord-022053-idft1p6d 242 3 diagnostics diagnostic NNS cord-022053-idft1p6d 242 4 are be VBP cord-022053-idft1p6d 242 5 heavily heavily RB cord-022053-idft1p6d 242 6 focused focus VBN cord-022053-idft1p6d 242 7 on on IN cord-022053-idft1p6d 242 8 CSF CSF NNP cord-022053-idft1p6d 242 9 biochemical biochemical JJ cord-022053-idft1p6d 242 10 profile profile NN cord-022053-idft1p6d 242 11 ( ( -LRB- cord-022053-idft1p6d 242 12 glucose glucose NN cord-022053-idft1p6d 242 13 , , , cord-022053-idft1p6d 242 14 protein protein NN cord-022053-idft1p6d 242 15 , , , cord-022053-idft1p6d 242 16 lactate lactate NN cord-022053-idft1p6d 242 17 ) ) -RRB- cord-022053-idft1p6d 242 18 , , , cord-022053-idft1p6d 242 19 cell cell NN cord-022053-idft1p6d 242 20 count count NN cord-022053-idft1p6d 242 21 , , , cord-022053-idft1p6d 242 22 and and CC cord-022053-idft1p6d 242 23 Gram Gram NNP cord-022053-idft1p6d 242 24 stain stain NN cord-022053-idft1p6d 242 25 . . . cord-022053-idft1p6d 243 1 The the DT cord-022053-idft1p6d 243 2 latter latter JJ cord-022053-idft1p6d 243 3 is be VBZ cord-022053-idft1p6d 243 4 the the DT cord-022053-idft1p6d 243 5 most most RBS cord-022053-idft1p6d 243 6 specific specific JJ cord-022053-idft1p6d 243 7 , , , cord-022053-idft1p6d 243 8 but but CC cord-022053-idft1p6d 243 9 the the DT cord-022053-idft1p6d 243 10 limit limit NN cord-022053-idft1p6d 243 11 of of IN cord-022053-idft1p6d 243 12 detection detection NN cord-022053-idft1p6d 243 13 is be VBZ cord-022053-idft1p6d 243 14 approximately approximately RB cord-022053-idft1p6d 243 15 10 10 CD cord-022053-idft1p6d 243 16 ( ( -LRB- cord-022053-idft1p6d 243 17 4 4 CD cord-022053-idft1p6d 243 18 ) ) -RRB- cord-022053-idft1p6d 243 19 accomplished accomplish VBN cord-022053-idft1p6d 243 20 by by IN cord-022053-idft1p6d 243 21 the the DT cord-022053-idft1p6d 243 22 introduction introduction NN cord-022053-idft1p6d 243 23 of of IN cord-022053-idft1p6d 243 24 helicase helicase NN cord-022053-idft1p6d 243 25 , , , cord-022053-idft1p6d 243 26 which which WDT cord-022053-idft1p6d 243 27 unwinds unwind VBZ cord-022053-idft1p6d 243 28 DNA DNA NNP cord-022053-idft1p6d 243 29 , , , cord-022053-idft1p6d 243 30 and and CC cord-022053-idft1p6d 243 31 single single RB cord-022053-idft1p6d 243 32 - - HYPH cord-022053-idft1p6d 243 33 stranded strand VBN cord-022053-idft1p6d 243 34 DNA dna NN cord-022053-idft1p6d 243 35 binding binding NN cord-022053-idft1p6d 243 36 proteins protein NNS cord-022053-idft1p6d 243 37 , , , cord-022053-idft1p6d 243 38 which which WDT cord-022053-idft1p6d 243 39 keep keep VBP cord-022053-idft1p6d 243 40 the the DT cord-022053-idft1p6d 243 41 templates template NNS cord-022053-idft1p6d 243 42 separated separate VBN cord-022053-idft1p6d 243 43 . . . cord-022053-idft1p6d 244 1 This this DT cord-022053-idft1p6d 244 2 is be VBZ cord-022053-idft1p6d 244 3 followed follow VBN cord-022053-idft1p6d 244 4 by by IN cord-022053-idft1p6d 244 5 primer primer NN cord-022053-idft1p6d 244 6 hybridization hybridization NN cord-022053-idft1p6d 244 7 and and CC cord-022053-idft1p6d 244 8 amplification amplification NN cord-022053-idft1p6d 244 9 to to TO cord-022053-idft1p6d 244 10 produce produce VB cord-022053-idft1p6d 244 11 more more JJR cord-022053-idft1p6d 244 12 single single RB cord-022053-idft1p6d 244 13 - - HYPH cord-022053-idft1p6d 244 14 stranded strand VBN cord-022053-idft1p6d 244 15 DNA dna NN cord-022053-idft1p6d 244 16 and and CC cord-022053-idft1p6d 244 17 thus thus RB cord-022053-idft1p6d 244 18 a a DT cord-022053-idft1p6d 244 19 continuous continuous JJ cord-022053-idft1p6d 244 20 reaction reaction NN cord-022053-idft1p6d 244 21 . . . cord-022053-idft1p6d 245 1 Assays assay NNS cord-022053-idft1p6d 245 2 to to TO cord-022053-idft1p6d 245 3 measure measure VB cord-022053-idft1p6d 245 4 herpes herpes NN cord-022053-idft1p6d 245 5 simplex simplex NN cord-022053-idft1p6d 245 6 virus virus NN cord-022053-idft1p6d 246 1 ( ( -LRB- cord-022053-idft1p6d 246 2 HSV)-1 HSV)-1 NNP cord-022053-idft1p6d 246 3 and and CC cord-022053-idft1p6d 246 4 HSV-2 HSV-2 NNP cord-022053-idft1p6d 246 5 using use VBG cord-022053-idft1p6d 246 6 helicase helicase NNP cord-022053-idft1p6d 246 7 have have VBP cord-022053-idft1p6d 246 8 been be VBN cord-022053-idft1p6d 246 9 developed develop VBN cord-022053-idft1p6d 246 10 with with IN cord-022053-idft1p6d 246 11 similar similar JJ cord-022053-idft1p6d 246 12 performance performance NN cord-022053-idft1p6d 246 13 to to IN cord-022053-idft1p6d 246 14 traditional traditional JJ cord-022053-idft1p6d 246 15 molecular molecular JJ cord-022053-idft1p6d 246 16 methods method NNS cord-022053-idft1p6d 246 17 and and CC cord-022053-idft1p6d 246 18 assays assay NNS cord-022053-idft1p6d 246 19 are be VBP cord-022053-idft1p6d 246 20 available available JJ cord-022053-idft1p6d 246 21 for for IN cord-022053-idft1p6d 246 22 Bordetella Bordetella NNP cord-022053-idft1p6d 246 23 , , , cord-022053-idft1p6d 246 24 group group NN cord-022053-idft1p6d 246 25 A a DT cord-022053-idft1p6d 246 26 Streptococcus Streptococcus NNP cord-022053-idft1p6d 246 27 , , , cord-022053-idft1p6d 246 28 Trichomonas Trichomonas NNP cord-022053-idft1p6d 246 29 , , , cord-022053-idft1p6d 246 30 and and CC cord-022053-idft1p6d 246 31 malaria malaria NN cord-022053-idft1p6d 246 32 . . . cord-022053-idft1p6d 247 1 73 73 CD cord-022053-idft1p6d 247 2 Commonly commonly RB cord-022053-idft1p6d 247 3 used use VBN cord-022053-idft1p6d 247 4 platforms platform NNS cord-022053-idft1p6d 247 5 that that WDT cord-022053-idft1p6d 247 6 use use VBP cord-022053-idft1p6d 247 7 these these DT cord-022053-idft1p6d 247 8 technologies technology NNS cord-022053-idft1p6d 247 9 include include VBP cord-022053-idft1p6d 247 10 the the DT cord-022053-idft1p6d 247 11 Tigris Tigris NNP cord-022053-idft1p6d 247 12 and and CC cord-022053-idft1p6d 247 13 Panther Panther NNP cord-022053-idft1p6d 247 14 systems system NNS cord-022053-idft1p6d 247 15 by by IN cord-022053-idft1p6d 247 16 Gen Gen NNP cord-022053-idft1p6d 247 17 - - HYPH cord-022053-idft1p6d 247 18 Probe Probe NNP cord-022053-idft1p6d 247 19 , , , cord-022053-idft1p6d 247 20 which which WDT cord-022053-idft1p6d 247 21 are be VBP cord-022053-idft1p6d 247 22 based base VBN cord-022053-idft1p6d 247 23 on on IN cord-022053-idft1p6d 247 24 TMA TMA NNP cord-022053-idft1p6d 247 25 , , , cord-022053-idft1p6d 247 26 SmMIT SmMIT NNP cord-022053-idft1p6d 247 27 - - HYPH cord-022053-idft1p6d 247 28 LAMP LAMP NNP cord-022053-idft1p6d 247 29 based base VBN cord-022053-idft1p6d 247 30 on on IN cord-022053-idft1p6d 247 31 LAMP lamp NN cord-022053-idft1p6d 247 32 , , , cord-022053-idft1p6d 247 33 and and CC cord-022053-idft1p6d 247 34 Ampli Ampli NNP cord-022053-idft1p6d 247 35 - - HYPH cord-022053-idft1p6d 247 36 Vue Vue NNP cord-022053-idft1p6d 247 37 based base VBN cord-022053-idft1p6d 247 38 on on IN cord-022053-idft1p6d 247 39 helicase helicase NN cord-022053-idft1p6d 247 40 . . . cord-022053-idft1p6d 248 1 Use use NN cord-022053-idft1p6d 248 2 of of IN cord-022053-idft1p6d 248 3 these these DT cord-022053-idft1p6d 248 4 assays assay NNS cord-022053-idft1p6d 248 5 in in IN cord-022053-idft1p6d 248 6 FFPE FFPE NNP cord-022053-idft1p6d 248 7 tissue tissue NN cord-022053-idft1p6d 248 8 has have VBZ cord-022053-idft1p6d 248 9 shown show VBN cord-022053-idft1p6d 248 10 some some DT cord-022053-idft1p6d 248 11 promise promise NN cord-022053-idft1p6d 248 12 with with IN cord-022053-idft1p6d 248 13 improved improved JJ cord-022053-idft1p6d 248 14 performance performance NN cord-022053-idft1p6d 248 15 over over IN cord-022053-idft1p6d 248 16 PCR PCR NNP cord-022053-idft1p6d 248 17 for for IN cord-022053-idft1p6d 248 18 some some DT cord-022053-idft1p6d 248 19 organisms organism NNS cord-022053-idft1p6d 248 20 ( ( -LRB- cord-022053-idft1p6d 248 21 such such JJ cord-022053-idft1p6d 248 22 as as IN cord-022053-idft1p6d 248 23 HCV HCV NNP cord-022053-idft1p6d 248 24 in in IN cord-022053-idft1p6d 248 25 TMA TMA NNP cord-022053-idft1p6d 248 26 ) ) -RRB- cord-022053-idft1p6d 248 27 , , , cord-022053-idft1p6d 248 28 equivalent equivalent JJ cord-022053-idft1p6d 248 29 performance performance NN cord-022053-idft1p6d 248 30 to to IN cord-022053-idft1p6d 248 31 PCR PCR NNP cord-022053-idft1p6d 248 32 ( ( -LRB- cord-022053-idft1p6d 248 33 such such JJ cord-022053-idft1p6d 248 34 as as IN cord-022053-idft1p6d 248 35 human human JJ cord-022053-idft1p6d 248 36 papillomavirus papillomavirus NN cord-022053-idft1p6d 248 37 [ [ -LRB- cord-022053-idft1p6d 248 38 HPV HPV NNP cord-022053-idft1p6d 248 39 ] ] -RRB- cord-022053-idft1p6d 248 40 in in IN cord-022053-idft1p6d 248 41 head head NN cord-022053-idft1p6d 248 42 and and CC cord-022053-idft1p6d 248 43 neck neck NN cord-022053-idft1p6d 248 44 cancers cancer NNS cord-022053-idft1p6d 248 45 with with IN cord-022053-idft1p6d 248 46 LAMP LAMP NNP cord-022053-idft1p6d 248 47 ) ) -RRB- cord-022053-idft1p6d 248 48 , , , cord-022053-idft1p6d 248 49 and and CC cord-022053-idft1p6d 248 50 detection detection NN cord-022053-idft1p6d 248 51 of of IN cord-022053-idft1p6d 248 52 limited limited JJ cord-022053-idft1p6d 248 53 signatures signature NNS cord-022053-idft1p6d 248 54 ( ( -LRB- cord-022053-idft1p6d 248 55 such such JJ cord-022053-idft1p6d 248 56 as as IN cord-022053-idft1p6d 248 57 microcarcinomas microcarcinomas NN cord-022053-idft1p6d 248 58 in in IN cord-022053-idft1p6d 248 59 small small JJ cord-022053-idft1p6d 248 60 biopsies biopsy NNS cord-022053-idft1p6d 248 61 with with IN cord-022053-idft1p6d 248 62 helicase helicase NN cord-022053-idft1p6d 248 63 assays assay NNS cord-022053-idft1p6d 248 64 ) ) -RRB- cord-022053-idft1p6d 248 65 . . . cord-022053-idft1p6d 249 1 [ [ -LRB- cord-022053-idft1p6d 249 2 74 74 CD cord-022053-idft1p6d 249 3 ] ] -RRB- cord-022053-idft1p6d 249 4 [ [ -LRB- cord-022053-idft1p6d 249 5 75 75 CD cord-022053-idft1p6d 249 6 ] ] -RRB- cord-022053-idft1p6d 250 1 [ [ -LRB- cord-022053-idft1p6d 250 2 76 76 CD cord-022053-idft1p6d 250 3 ] ] -RRB- cord-022053-idft1p6d 250 4 _SP cord-022053-idft1p6d 251 1 The the DT cord-022053-idft1p6d 251 2 ability ability NN cord-022053-idft1p6d 251 3 to to TO cord-022053-idft1p6d 251 4 detect detect VB cord-022053-idft1p6d 251 5 multiple multiple JJ cord-022053-idft1p6d 251 6 organisms organism NNS cord-022053-idft1p6d 251 7 in in IN cord-022053-idft1p6d 251 8 primary primary JJ cord-022053-idft1p6d 251 9 samples sample NNS cord-022053-idft1p6d 251 10 using use VBG cord-022053-idft1p6d 251 11 PCR PCR NNP cord-022053-idft1p6d 251 12 - - HYPH cord-022053-idft1p6d 251 13 based base VBN cord-022053-idft1p6d 251 14 panels panel NNS cord-022053-idft1p6d 251 15 has have VBZ cord-022053-idft1p6d 251 16 both both DT cord-022053-idft1p6d 251 17 provided provide VBN cord-022053-idft1p6d 251 18 clinicians clinician NNS cord-022053-idft1p6d 251 19 with with IN cord-022053-idft1p6d 251 20 tremendous tremendous JJ cord-022053-idft1p6d 251 21 diagnostic diagnostic JJ cord-022053-idft1p6d 251 22 opportunities opportunity NNS cord-022053-idft1p6d 251 23 and and CC cord-022053-idft1p6d 251 24 presented present VBD cord-022053-idft1p6d 251 25 new new JJ cord-022053-idft1p6d 251 26 challenges challenge NNS cord-022053-idft1p6d 251 27 . . . cord-022053-idft1p6d 252 1 77 77 CD cord-022053-idft1p6d 252 2 Major major JJ cord-022053-idft1p6d 252 3 platforms platform NNS cord-022053-idft1p6d 252 4 include include VBP cord-022053-idft1p6d 252 5 FilmArray FilmArray NNP cord-022053-idft1p6d 252 6 ( ( -LRB- cord-022053-idft1p6d 252 7 BioMérieux BioMérieux NNP cord-022053-idft1p6d 252 8 ) ) -RRB- cord-022053-idft1p6d 252 9 , , , cord-022053-idft1p6d 252 10 Verigene Verigene NNP cord-022053-idft1p6d 252 11 ( ( -LRB- cord-022053-idft1p6d 252 12 Nanosphere Nanosphere NNP cord-022053-idft1p6d 252 13 ) ) -RRB- cord-022053-idft1p6d 252 14 , , , cord-022053-idft1p6d 252 15 xTAG xTAG VBN cord-022053-idft1p6d 252 16 / / SYM cord-022053-idft1p6d 252 17 xMAP xMAP . cord-022053-idft1p6d 253 1 ( ( -LRB- cord-022053-idft1p6d 253 2 Luminex Luminex NNP cord-022053-idft1p6d 253 3 , , , cord-022053-idft1p6d 253 4 Austin Austin NNP cord-022053-idft1p6d 253 5 , , , cord-022053-idft1p6d 253 6 Texas Texas NNP cord-022053-idft1p6d 253 7 ) ) -RRB- cord-022053-idft1p6d 253 8 , , , cord-022053-idft1p6d 253 9 with with IN cord-022053-idft1p6d 253 10 technologies technology NNS cord-022053-idft1p6d 253 11 that that WDT cord-022053-idft1p6d 253 12 range range VBP cord-022053-idft1p6d 253 13 from from IN cord-022053-idft1p6d 253 14 real real JJ cord-022053-idft1p6d 253 15 - - HYPH cord-022053-idft1p6d 253 16 time time NN cord-022053-idft1p6d 253 17 PCR PCR NNP cord-022053-idft1p6d 253 18 to to TO cord-022053-idft1p6d 253 19 solid solid JJ cord-022053-idft1p6d 253 20 and and CC cord-022053-idft1p6d 253 21 liquid liquid JJ cord-022053-idft1p6d 253 22 phase phase NN cord-022053-idft1p6d 253 23 arrays array NNS cord-022053-idft1p6d 253 24 . . . cord-022053-idft1p6d 254 1 For for IN cord-022053-idft1p6d 254 2 a a DT cord-022053-idft1p6d 254 3 comprehensive comprehensive JJ cord-022053-idft1p6d 254 4 listing listing NN cord-022053-idft1p6d 254 5 of of IN cord-022053-idft1p6d 254 6 platforms platform NNS cord-022053-idft1p6d 254 7 see see VB cord-022053-idft1p6d 254 8 www.captodayonline.com/ www.captodayonline.com/ NNP cord-022053-idft1p6d 254 9 productguides productguide NNS cord-022053-idft1p6d 254 10 . . . cord-022053-idft1p6d 255 1 For for IN cord-022053-idft1p6d 255 2 an an DT cord-022053-idft1p6d 255 3 in in IN cord-022053-idft1p6d 255 4 - - HYPH cord-022053-idft1p6d 255 5 depth depth NN cord-022053-idft1p6d 255 6 discussion discussion NN cord-022053-idft1p6d 255 7 of of IN cord-022053-idft1p6d 255 8 the the DT cord-022053-idft1p6d 255 9 major major JJ cord-022053-idft1p6d 255 10 technologies technology NNS cord-022053-idft1p6d 255 11 see see VBP cord-022053-idft1p6d 255 12 the the DT cord-022053-idft1p6d 255 13 articles article NNS cord-022053-idft1p6d 255 14 included include VBN cord-022053-idft1p6d 255 15 in in IN cord-022053-idft1p6d 255 16 the the DT cord-022053-idft1p6d 255 17 reference reference NN cord-022053-idft1p6d 255 18 list list NN cord-022053-idft1p6d 255 19 . . . cord-022053-idft1p6d 256 1 78 78 CD cord-022053-idft1p6d 256 2 , , , cord-022053-idft1p6d 256 3 79 79 CD cord-022053-idft1p6d 257 1 These these DT cord-022053-idft1p6d 257 2 systems system NNS cord-022053-idft1p6d 257 3 are be VBP cord-022053-idft1p6d 257 4 generally generally RB cord-022053-idft1p6d 257 5 geared gear VBN cord-022053-idft1p6d 257 6 towards towards IN cord-022053-idft1p6d 257 7 syndromic syndromic JJ cord-022053-idft1p6d 257 8 testing testing NN cord-022053-idft1p6d 257 9 , , , cord-022053-idft1p6d 257 10 with with IN cord-022053-idft1p6d 257 11 panels panel NNS cord-022053-idft1p6d 257 12 directed direct VBN cord-022053-idft1p6d 257 13 towards towards IN cord-022053-idft1p6d 257 14 respiratory respiratory JJ cord-022053-idft1p6d 257 15 , , , cord-022053-idft1p6d 257 16 GI GI NNP cord-022053-idft1p6d 257 17 , , , cord-022053-idft1p6d 257 18 and and CC cord-022053-idft1p6d 257 19 sexually sexually RB cord-022053-idft1p6d 257 20 transmitted transmit VBN cord-022053-idft1p6d 257 21 diseases disease NNS cord-022053-idft1p6d 257 22 , , , cord-022053-idft1p6d 257 23 as as RB cord-022053-idft1p6d 257 24 well well RB cord-022053-idft1p6d 257 25 as as IN cord-022053-idft1p6d 257 26 meningitis meningitis NN cord-022053-idft1p6d 257 27 and and CC cord-022053-idft1p6d 257 28 bloodstream bloodstream NN cord-022053-idft1p6d 257 29 infections infection NNS cord-022053-idft1p6d 257 30 . . . cord-022053-idft1p6d 258 1 After after IN cord-022053-idft1p6d 258 2 discussing discuss VBG cord-022053-idft1p6d 258 3 the the DT cord-022053-idft1p6d 258 4 specific specific JJ cord-022053-idft1p6d 258 5 challenges challenge NNS cord-022053-idft1p6d 258 6 of of IN cord-022053-idft1p6d 258 7 each each DT cord-022053-idft1p6d 258 8 of of IN cord-022053-idft1p6d 258 9 the the DT cord-022053-idft1p6d 258 10 major major JJ cord-022053-idft1p6d 258 11 syndromes syndrome NNS cord-022053-idft1p6d 258 12 , , , cord-022053-idft1p6d 258 13 this this DT cord-022053-idft1p6d 258 14 section section NN cord-022053-idft1p6d 258 15 will will MD cord-022053-idft1p6d 258 16 focus focus VB cord-022053-idft1p6d 258 17 on on IN cord-022053-idft1p6d 258 18 commonly commonly RB cord-022053-idft1p6d 258 19 used use VBN cord-022053-idft1p6d 258 20 FDA FDA NNP cord-022053-idft1p6d 258 21 - - HYPH cord-022053-idft1p6d 258 22 approved approve VBN cord-022053-idft1p6d 258 23 panels panel NNS cord-022053-idft1p6d 258 24 that that WDT cord-022053-idft1p6d 258 25 are be VBP cord-022053-idft1p6d 258 26 currently currently RB cord-022053-idft1p6d 258 27 available available JJ cord-022053-idft1p6d 258 28 from from IN cord-022053-idft1p6d 258 29 a a DT cord-022053-idft1p6d 258 30 number number NN cord-022053-idft1p6d 258 31 of of IN cord-022053-idft1p6d 258 32 manufacturers manufacturer NNS cord-022053-idft1p6d 258 33 and and CC cord-022053-idft1p6d 258 34 that that IN cord-022053-idft1p6d 258 35 scan scan NN cord-022053-idft1p6d 258 36 for for IN cord-022053-idft1p6d 258 37 a a DT cord-022053-idft1p6d 258 38 wide wide JJ cord-022053-idft1p6d 258 39 array array NN cord-022053-idft1p6d 258 40 of of IN cord-022053-idft1p6d 258 41 microbes microbe NNS cord-022053-idft1p6d 258 42 , , , cord-022053-idft1p6d 258 43 encompassing encompass VBG cord-022053-idft1p6d 258 44 viral viral JJ cord-022053-idft1p6d 258 45 , , , cord-022053-idft1p6d 258 46 bacterial bacterial JJ cord-022053-idft1p6d 258 47 , , , cord-022053-idft1p6d 258 48 and and CC cord-022053-idft1p6d 258 49 fungal fungal JJ cord-022053-idft1p6d 258 50 organisms organism NNS cord-022053-idft1p6d 258 51 . . . cord-022053-idft1p6d 259 1 Panels panel NNS cord-022053-idft1p6d 259 2 aimed aim VBN cord-022053-idft1p6d 259 3 at at IN cord-022053-idft1p6d 259 4 respiratory respiratory JJ cord-022053-idft1p6d 259 5 pathogens pathogen NNS cord-022053-idft1p6d 259 6 are be VBP cord-022053-idft1p6d 259 7 focused focus VBN cord-022053-idft1p6d 259 8 most most RBS cord-022053-idft1p6d 259 9 heavily heavily RB cord-022053-idft1p6d 259 10 on on IN cord-022053-idft1p6d 259 11 viruses virus NNS cord-022053-idft1p6d 259 12 but but CC cord-022053-idft1p6d 259 13 also also RB cord-022053-idft1p6d 259 14 incorporate incorporate VB cord-022053-idft1p6d 259 15 several several JJ cord-022053-idft1p6d 259 16 bacterial bacterial JJ cord-022053-idft1p6d 259 17 agents agent NNS cord-022053-idft1p6d 259 18 . . . cord-022053-idft1p6d 260 1 80 80 CD cord-022053-idft1p6d 260 2 , , , cord-022053-idft1p6d 260 3 81 81 CD cord-022053-idft1p6d 260 4 Commonly commonly RB cord-022053-idft1p6d 260 5 covered cover VBN cord-022053-idft1p6d 260 6 organisms organism NNS cord-022053-idft1p6d 260 7 include include VBP cord-022053-idft1p6d 260 8 Mycoplasma mycoplasma NN cord-022053-idft1p6d 260 9 pneumoniae pneumoniae NNS cord-022053-idft1p6d 260 10 , , , cord-022053-idft1p6d 260 11 Chlamydia Chlamydia NNP cord-022053-idft1p6d 260 12 pneumoniae pneumoniae NN cord-022053-idft1p6d 260 13 , , , cord-022053-idft1p6d 260 14 and and CC cord-022053-idft1p6d 260 15 Bordetella Bordetella NNP cord-022053-idft1p6d 260 16 species specie NNS cord-022053-idft1p6d 260 17 . . . cord-022053-idft1p6d 261 1 M. M. NNP cord-022053-idft1p6d 261 2 pneumoniae pneumoniae NN cord-022053-idft1p6d 261 3 and and CC cord-022053-idft1p6d 261 4 C. C. NNP cord-022053-idft1p6d 261 5 pneumoniae pneumoniae NNS cord-022053-idft1p6d 261 6 , , , cord-022053-idft1p6d 261 7 both both CC cord-022053-idft1p6d 261 8 very very RB cord-022053-idft1p6d 261 9 common common JJ cord-022053-idft1p6d 261 10 causes cause NNS cord-022053-idft1p6d 261 11 of of IN cord-022053-idft1p6d 261 12 communityacquired communityacquired JJ cord-022053-idft1p6d 261 13 pneumonia pneumonia NN cord-022053-idft1p6d 261 14 , , , cord-022053-idft1p6d 261 15 are be VBP cord-022053-idft1p6d 261 16 particularly particularly RB cord-022053-idft1p6d 261 17 well well RB cord-022053-idft1p6d 261 18 - - HYPH cord-022053-idft1p6d 261 19 suited suit VBN cord-022053-idft1p6d 261 20 to to IN cord-022053-idft1p6d 261 21 nucleic nucleic JJ cord-022053-idft1p6d 261 22 acid acid NN cord-022053-idft1p6d 261 23 amplification amplification NN cord-022053-idft1p6d 261 24 tests test NNS cord-022053-idft1p6d 261 25 because because IN cord-022053-idft1p6d 261 26 they -PRON- PRP cord-022053-idft1p6d 261 27 are be VBP cord-022053-idft1p6d 261 28 difficult difficult JJ cord-022053-idft1p6d 261 29 to to TO cord-022053-idft1p6d 261 30 culture culture NN cord-022053-idft1p6d 261 31 . . . cord-022053-idft1p6d 262 1 82 82 CD cord-022053-idft1p6d 263 1 Although although IN cord-022053-idft1p6d 263 2 less less RBR cord-022053-idft1p6d 263 3 common common JJ cord-022053-idft1p6d 263 4 , , , cord-022053-idft1p6d 263 5 Bordetella Bordetella NNP cord-022053-idft1p6d 263 6 pertussis pertussis NN cord-022053-idft1p6d 263 7 is be VBZ cord-022053-idft1p6d 263 8 considered consider VBN cord-022053-idft1p6d 263 9 to to TO cord-022053-idft1p6d 263 10 be be VB cord-022053-idft1p6d 263 11 the the DT cord-022053-idft1p6d 263 12 most most RBS cord-022053-idft1p6d 263 13 common common JJ cord-022053-idft1p6d 263 14 vaccine vaccine NN cord-022053-idft1p6d 263 15 - - HYPH cord-022053-idft1p6d 263 16 preventable preventable JJ cord-022053-idft1p6d 263 17 disease disease NN cord-022053-idft1p6d 263 18 in in IN cord-022053-idft1p6d 263 19 the the DT cord-022053-idft1p6d 263 20 United United NNP cord-022053-idft1p6d 263 21 States States NNP cord-022053-idft1p6d 263 22 , , , cord-022053-idft1p6d 263 23 is be VBZ cord-022053-idft1p6d 263 24 increasing increase VBG cord-022053-idft1p6d 263 25 in in IN cord-022053-idft1p6d 263 26 incidence incidence NN cord-022053-idft1p6d 263 27 , , , cord-022053-idft1p6d 263 28 and and CC cord-022053-idft1p6d 263 29 is be VBZ cord-022053-idft1p6d 263 30 also also RB cord-022053-idft1p6d 263 31 difficult difficult JJ cord-022053-idft1p6d 263 32 to to TO cord-022053-idft1p6d 263 33 culture culture NN cord-022053-idft1p6d 263 34 . . . cord-022053-idft1p6d 264 1 83 83 CD cord-022053-idft1p6d 265 1 The the DT cord-022053-idft1p6d 265 2 " " `` cord-022053-idft1p6d 265 3 bread bread NN cord-022053-idft1p6d 265 4 and and CC cord-022053-idft1p6d 265 5 butter butter NN cord-022053-idft1p6d 265 6 " " '' cord-022053-idft1p6d 265 7 of of IN cord-022053-idft1p6d 265 8 respiratory respiratory JJ cord-022053-idft1p6d 265 9 panels panel NNS cord-022053-idft1p6d 265 10 ( ( -LRB- cord-022053-idft1p6d 265 11 RPs rp NNS cord-022053-idft1p6d 265 12 ) ) -RRB- cord-022053-idft1p6d 265 13 focus focus VBP cord-022053-idft1p6d 265 14 on on IN cord-022053-idft1p6d 265 15 viruses virus NNS cord-022053-idft1p6d 265 16 with with IN cord-022053-idft1p6d 265 17 influenza influenza NN cord-022053-idft1p6d 265 18 A a NN cord-022053-idft1p6d 265 19 ( ( -LRB- cord-022053-idft1p6d 265 20 and and CC cord-022053-idft1p6d 265 21 B B NNP cord-022053-idft1p6d 265 22 ) ) -RRB- cord-022053-idft1p6d 265 23 , , , cord-022053-idft1p6d 265 24 adenovirus adenovirus NN cord-022053-idft1p6d 265 25 , , , cord-022053-idft1p6d 265 26 and and CC cord-022053-idft1p6d 265 27 respiratory respiratory JJ cord-022053-idft1p6d 265 28 syncytial syncytial JJ cord-022053-idft1p6d 265 29 virus virus NN cord-022053-idft1p6d 265 30 ( ( -LRB- cord-022053-idft1p6d 265 31 RSV RSV NNP cord-022053-idft1p6d 265 32 ) ) -RRB- cord-022053-idft1p6d 265 33 being be VBG cord-022053-idft1p6d 265 34 always always RB cord-022053-idft1p6d 265 35 including include VBG cord-022053-idft1p6d 265 36 , , , cord-022053-idft1p6d 265 37 along along IN cord-022053-idft1p6d 265 38 with with IN cord-022053-idft1p6d 265 39 a a DT cord-022053-idft1p6d 265 40 mixture mixture NN cord-022053-idft1p6d 265 41 of of IN cord-022053-idft1p6d 265 42 other other JJ cord-022053-idft1p6d 265 43 coronavirus coronavirus NN cord-022053-idft1p6d 265 44 , , , cord-022053-idft1p6d 265 45 enterovirus enterovirus NN cord-022053-idft1p6d 265 46 , , , cord-022053-idft1p6d 265 47 metapneumovirus metapneumovirus NNP cord-022053-idft1p6d 265 48 , , , cord-022053-idft1p6d 265 49 and and CC cord-022053-idft1p6d 265 50 the the DT cord-022053-idft1p6d 265 51 parainfluenza parainfluenza NNP cord-022053-idft1p6d 265 52 group group NNP cord-022053-idft1p6d 265 53 . . . cord-022053-idft1p6d 266 1 These these DT cord-022053-idft1p6d 266 2 panels panel NNS cord-022053-idft1p6d 266 3 are be VBP cord-022053-idft1p6d 266 4 extremely extremely RB cord-022053-idft1p6d 266 5 powerful powerful JJ cord-022053-idft1p6d 266 6 from from IN cord-022053-idft1p6d 266 7 the the DT cord-022053-idft1p6d 266 8 clinician clinician NN cord-022053-idft1p6d 266 9 's 's POS cord-022053-idft1p6d 266 10 point point NN cord-022053-idft1p6d 266 11 of of IN cord-022053-idft1p6d 266 12 view view NN cord-022053-idft1p6d 266 13 but but CC cord-022053-idft1p6d 266 14 also also RB cord-022053-idft1p6d 266 15 provide provide VB cord-022053-idft1p6d 266 16 a a DT cord-022053-idft1p6d 266 17 larger large JJR cord-022053-idft1p6d 266 18 range range NN cord-022053-idft1p6d 266 19 of of IN cord-022053-idft1p6d 266 20 diagnostics diagnostic NNS cord-022053-idft1p6d 266 21 for for IN cord-022053-idft1p6d 266 22 respiratory respiratory JJ cord-022053-idft1p6d 266 23 viruses virus NNS cord-022053-idft1p6d 266 24 than than IN cord-022053-idft1p6d 266 25 can can MD cord-022053-idft1p6d 266 26 be be VB cord-022053-idft1p6d 266 27 found find VBN cord-022053-idft1p6d 266 28 in in IN cord-022053-idft1p6d 266 29 most most JJS cord-022053-idft1p6d 266 30 anatomic anatomic JJ cord-022053-idft1p6d 266 31 pathology pathology NN cord-022053-idft1p6d 266 32 labs lab NNS cord-022053-idft1p6d 266 33 , , , cord-022053-idft1p6d 266 34 which which WDT cord-022053-idft1p6d 266 35 are be VBP cord-022053-idft1p6d 266 36 largely largely RB cord-022053-idft1p6d 266 37 limited limited JJ cord-022053-idft1p6d 266 38 to to IN cord-022053-idft1p6d 266 39 the the DT cord-022053-idft1p6d 266 40 DNA dna NN cord-022053-idft1p6d 266 41 viruses virus NNS cord-022053-idft1p6d 266 42 . . . cord-022053-idft1p6d 267 1 Although although IN cord-022053-idft1p6d 267 2 not not RB cord-022053-idft1p6d 267 3 all all DT cord-022053-idft1p6d 267 4 of of IN cord-022053-idft1p6d 267 5 these these DT cord-022053-idft1p6d 267 6 viral viral JJ cord-022053-idft1p6d 267 7 diagnoses diagnosis NNS cord-022053-idft1p6d 267 8 are be VBP cord-022053-idft1p6d 267 9 chemotherapeutically chemotherapeutically RB cord-022053-idft1p6d 267 10 actionable actionable JJ cord-022053-idft1p6d 267 11 , , , cord-022053-idft1p6d 267 12 confirmation confirmation NN cord-022053-idft1p6d 267 13 of of IN cord-022053-idft1p6d 267 14 a a DT cord-022053-idft1p6d 267 15 viral viral JJ cord-022053-idft1p6d 267 16 cause cause NN cord-022053-idft1p6d 267 17 is be VBZ cord-022053-idft1p6d 267 18 valuable valuable JJ cord-022053-idft1p6d 267 19 for for IN cord-022053-idft1p6d 267 20 prognosis prognosis NN cord-022053-idft1p6d 267 21 and and CC cord-022053-idft1p6d 267 22 resource resource NN cord-022053-idft1p6d 267 23 allocation allocation NN cord-022053-idft1p6d 267 24 . . . cord-022053-idft1p6d 268 1 Diarrheal diarrheal JJ cord-022053-idft1p6d 268 2 diseases disease NNS cord-022053-idft1p6d 268 3 are be VBP cord-022053-idft1p6d 268 4 a a DT cord-022053-idft1p6d 268 5 global global JJ cord-022053-idft1p6d 268 6 public public JJ cord-022053-idft1p6d 268 7 health health NN cord-022053-idft1p6d 268 8 concern concern NN cord-022053-idft1p6d 268 9 . . . cord-022053-idft1p6d 269 1 Although although IN cord-022053-idft1p6d 269 2 these these DT cord-022053-idft1p6d 269 3 diseases disease NNS cord-022053-idft1p6d 269 4 are be VBP cord-022053-idft1p6d 269 5 a a DT cord-022053-idft1p6d 269 6 common common JJ cord-022053-idft1p6d 269 7 cause cause NN cord-022053-idft1p6d 269 8 of of IN cord-022053-idft1p6d 269 9 illness illness NN cord-022053-idft1p6d 269 10 and and CC cord-022053-idft1p6d 269 11 hospitalization hospitalization NN cord-022053-idft1p6d 269 12 in in IN cord-022053-idft1p6d 269 13 the the DT cord-022053-idft1p6d 269 14 United United NNP cord-022053-idft1p6d 269 15 States States NNP cord-022053-idft1p6d 269 16 , , , cord-022053-idft1p6d 269 17 they -PRON- PRP cord-022053-idft1p6d 269 18 impose impose VBP cord-022053-idft1p6d 269 19 an an DT cord-022053-idft1p6d 269 20 enormous enormous JJ cord-022053-idft1p6d 269 21 toll toll NN cord-022053-idft1p6d 269 22 in in IN cord-022053-idft1p6d 269 23 the the DT cord-022053-idft1p6d 269 24 developing develop VBG cord-022053-idft1p6d 269 25 world world NN cord-022053-idft1p6d 269 26 , , , cord-022053-idft1p6d 269 27 particularly particularly RB cord-022053-idft1p6d 269 28 on on IN cord-022053-idft1p6d 269 29 children child NNS cord-022053-idft1p6d 269 30 . . . cord-022053-idft1p6d 270 1 The the DT cord-022053-idft1p6d 270 2 most most RBS cord-022053-idft1p6d 270 3 common common JJ cord-022053-idft1p6d 270 4 bacterial bacterial JJ cord-022053-idft1p6d 270 5 99.5 99.5 CD cord-022053-idft1p6d 270 6 % % NN cord-022053-idft1p6d 270 7 to to TO cord-022053-idft1p6d 270 8 100 100 CD cord-022053-idft1p6d 270 9 % % NN cord-022053-idft1p6d 270 10 ) ) -RRB- cord-022053-idft1p6d 270 11 , , . cord-022053-idft1p6d 271 1 but but CC cord-022053-idft1p6d 271 2 , , , cord-022053-idft1p6d 271 3 as as IN cord-022053-idft1p6d 271 4 has have VBZ cord-022053-idft1p6d 271 5 been be VBN cord-022053-idft1p6d 271 6 common common JJ cord-022053-idft1p6d 271 7 with with IN cord-022053-idft1p6d 271 8 many many JJ cord-022053-idft1p6d 271 9 panels panel NNS cord-022053-idft1p6d 271 10 and and CC cord-022053-idft1p6d 271 11 individual individual JJ cord-022053-idft1p6d 271 12 tests test NNS cord-022053-idft1p6d 271 13 , , , cord-022053-idft1p6d 271 14 laboratories laboratory NNS cord-022053-idft1p6d 271 15 have have VBP cord-022053-idft1p6d 271 16 difficulty difficulty NN cord-022053-idft1p6d 271 17 obtaining obtain VBG cord-022053-idft1p6d 271 18 natural natural JJ cord-022053-idft1p6d 271 19 clinical clinical JJ cord-022053-idft1p6d 271 20 cases case NNS cord-022053-idft1p6d 271 21 of of IN cord-022053-idft1p6d 271 22 E. E. NNP cord-022053-idft1p6d 271 23 histolytica histolytica NNP cord-022053-idft1p6d 271 24 . . . cord-022053-idft1p6d 272 1 103 103 CD cord-022053-idft1p6d 273 1 Currently currently RB cord-022053-idft1p6d 273 2 , , , cord-022053-idft1p6d 273 3 the the DT cord-022053-idft1p6d 273 4 only only JJ cord-022053-idft1p6d 273 5 FDA FDA NNP cord-022053-idft1p6d 273 6 - - HYPH cord-022053-idft1p6d 273 7 approved approve VBN cord-022053-idft1p6d 273 8 multiplex multiplex NN cord-022053-idft1p6d 273 9 assay assay NN cord-022053-idft1p6d 273 10 for for IN cord-022053-idft1p6d 273 11 agents agent NNS cord-022053-idft1p6d 273 12 of of IN cord-022053-idft1p6d 273 13 meningitis meningitis NN cord-022053-idft1p6d 273 14 and and CC cord-022053-idft1p6d 273 15 encephalitis encephalitis NN cord-022053-idft1p6d 273 16 is be VBZ cord-022053-idft1p6d 273 17 the the DT cord-022053-idft1p6d 273 18 FilmArray FilmArray NNP cord-022053-idft1p6d 273 19 meningitis meningitis NN cord-022053-idft1p6d 273 20 panel panel NN cord-022053-idft1p6d 273 21 . . . cord-022053-idft1p6d 274 1 It -PRON- PRP cord-022053-idft1p6d 274 2 covers cover VBZ cord-022053-idft1p6d 274 3 14 14 CD cord-022053-idft1p6d 274 4 pathogens pathogen NNS cord-022053-idft1p6d 274 5 , , , cord-022053-idft1p6d 274 6 including include VBG cord-022053-idft1p6d 274 7 the the DT cord-022053-idft1p6d 274 8 following follow VBG cord-022053-idft1p6d 274 9 bacteria bacteria NNS cord-022053-idft1p6d 274 10 : : : cord-022053-idft1p6d 274 11 E. E. NNP cord-022053-idft1p6d 274 12 coli coli VBZ cord-022053-idft1p6d 274 13 K1 K1 NNP cord-022053-idft1p6d 274 14 , , , cord-022053-idft1p6d 274 15 H. H. NNP cord-022053-idft1p6d 274 16 influenza influenza NN cord-022053-idft1p6d 274 17 , , , cord-022053-idft1p6d 274 18 L. L. NNP cord-022053-idft1p6d 274 19 monocytogenes monocytogenes NNP cord-022053-idft1p6d 274 20 , , , cord-022053-idft1p6d 274 21 N. N. NNP cord-022053-idft1p6d 274 22 meningitides meningitide NNS cord-022053-idft1p6d 274 23 , , , cord-022053-idft1p6d 274 24 S. S. NNP cord-022053-idft1p6d 274 25 agalactiae agalactiae NNP cord-022053-idft1p6d 274 26 , , , cord-022053-idft1p6d 274 27 and and CC cord-022053-idft1p6d 274 28 S. S. NNP cord-022053-idft1p6d 274 29 pneumoniae pneumoniae NN cord-022053-idft1p6d 274 30 . . . cord-022053-idft1p6d 275 1 Although although IN cord-022053-idft1p6d 275 2 the the DT cord-022053-idft1p6d 275 3 panel panel NN cord-022053-idft1p6d 275 4 was be VBD cord-022053-idft1p6d 275 5 only only RB cord-022053-idft1p6d 275 6 recently recently RB cord-022053-idft1p6d 275 7 approved approve VBN cord-022053-idft1p6d 275 8 by by IN cord-022053-idft1p6d 275 9 the the DT cord-022053-idft1p6d 275 10 FDA FDA NNP cord-022053-idft1p6d 275 11 ( ( -LRB- cord-022053-idft1p6d 275 12 October October NNP cord-022053-idft1p6d 275 13 2015 2015 CD cord-022053-idft1p6d 275 14 ) ) -RRB- cord-022053-idft1p6d 275 15 , , , cord-022053-idft1p6d 275 16 there there EX cord-022053-idft1p6d 275 17 are be VBP cord-022053-idft1p6d 275 18 a a DT cord-022053-idft1p6d 275 19 few few JJ cord-022053-idft1p6d 275 20 reports report NNS cord-022053-idft1p6d 275 21 of of IN cord-022053-idft1p6d 275 22 its -PRON- PRP$ cord-022053-idft1p6d 275 23 performance performance NN cord-022053-idft1p6d 275 24 . . . cord-022053-idft1p6d 276 1 The the DT cord-022053-idft1p6d 276 2 pre pre JJ cord-022053-idft1p6d 276 3 - - JJ cord-022053-idft1p6d 276 4 FDA FDA NNP cord-022053-idft1p6d 276 5 evaluation evaluation NN cord-022053-idft1p6d 276 6 was be VBD cord-022053-idft1p6d 276 7 conducted conduct VBN cord-022053-idft1p6d 276 8 both both CC cord-022053-idft1p6d 276 9 on on IN cord-022053-idft1p6d 276 10 archived archived JJ cord-022053-idft1p6d 276 11 samples sample NNS cord-022053-idft1p6d 276 12 and and CC cord-022053-idft1p6d 276 13 prospectively prospectively RB cord-022053-idft1p6d 276 14 on on IN cord-022053-idft1p6d 276 15 a a DT cord-022053-idft1p6d 276 16 multicenter multicenter JJ cord-022053-idft1p6d 276 17 collection collection NN cord-022053-idft1p6d 276 18 of of IN cord-022053-idft1p6d 276 19 1560 1560 CD cord-022053-idft1p6d 276 20 samples sample NNS cord-022053-idft1p6d 276 21 of of IN cord-022053-idft1p6d 276 22 CSF CSF NNP cord-022053-idft1p6d 276 23 . . . cord-022053-idft1p6d 277 1 Among among IN cord-022053-idft1p6d 277 2 235 235 CD cord-022053-idft1p6d 277 3 archived archived JJ cord-022053-idft1p6d 277 4 samples sample NNS cord-022053-idft1p6d 277 5 ( ( -LRB- cord-022053-idft1p6d 277 6 32 32 CD cord-022053-idft1p6d 277 7 with with IN cord-022053-idft1p6d 277 8 bacteria bacteria NNS cord-022053-idft1p6d 277 9 ) ) -RRB- cord-022053-idft1p6d 277 10 , , , cord-022053-idft1p6d 277 11 the the DT cord-022053-idft1p6d 277 12 percent percent NN cord-022053-idft1p6d 277 13 positive positive JJ cord-022053-idft1p6d 277 14 and and CC cord-022053-idft1p6d 277 15 negative negative JJ cord-022053-idft1p6d 277 16 agreement agreement NN cord-022053-idft1p6d 277 17 was be VBD cord-022053-idft1p6d 277 18 100 100 CD cord-022053-idft1p6d 277 19 % % NN cord-022053-idft1p6d 277 20 for for IN cord-022053-idft1p6d 277 21 bacterial bacterial JJ cord-022053-idft1p6d 277 22 targets target NNS cord-022053-idft1p6d 277 23 . . . cord-022053-idft1p6d 278 1 Among among IN cord-022053-idft1p6d 278 2 the the DT cord-022053-idft1p6d 278 3 1560 1560 CD cord-022053-idft1p6d 278 4 prospective prospective JJ cord-022053-idft1p6d 278 5 samples sample NNS cord-022053-idft1p6d 278 6 , , , cord-022053-idft1p6d 278 7 there there EX cord-022053-idft1p6d 278 8 were be VBD cord-022053-idft1p6d 278 9 only only RB cord-022053-idft1p6d 278 10 eight eight CD cord-022053-idft1p6d 278 11 with with IN cord-022053-idft1p6d 278 12 bacterial bacterial JJ cord-022053-idft1p6d 278 13 pathogens pathogen NNS cord-022053-idft1p6d 279 1 ( ( -LRB- cord-022053-idft1p6d 279 2 none none NN cord-022053-idft1p6d 279 3 with with IN cord-022053-idft1p6d 279 4 L. L. NNP cord-022053-idft1p6d 279 5 monocytogenes monocytogenes NNP cord-022053-idft1p6d 279 6 or or CC cord-022053-idft1p6d 279 7 N. N. NNP cord-022053-idft1p6d 279 8 meningitides meningitide NNS cord-022053-idft1p6d 279 9 ) ) -RRB- cord-022053-idft1p6d 279 10 . . . cord-022053-idft1p6d 280 1 Of of IN cord-022053-idft1p6d 280 2 those those DT cord-022053-idft1p6d 280 3 that that WDT cord-022053-idft1p6d 280 4 were be VBD cord-022053-idft1p6d 280 5 present present JJ cord-022053-idft1p6d 280 6 , , , cord-022053-idft1p6d 280 7 the the DT cord-022053-idft1p6d 280 8 FilmArray FilmArray NNP cord-022053-idft1p6d 280 9 ME ME NNP cord-022053-idft1p6d 280 10 panel panel NN cord-022053-idft1p6d 280 11 did do VBD cord-022053-idft1p6d 280 12 not not RB cord-022053-idft1p6d 280 13 identify identify VB cord-022053-idft1p6d 280 14 the the DT cord-022053-idft1p6d 280 15 only only JJ cord-022053-idft1p6d 280 16 S. S. NNP cord-022053-idft1p6d 280 17 agalactiae agalactiae NNP cord-022053-idft1p6d 280 18 . . . cord-022053-idft1p6d 281 1 The the DT cord-022053-idft1p6d 281 2 archived archived JJ cord-022053-idft1p6d 281 3 arm arm NN cord-022053-idft1p6d 281 4 of of IN cord-022053-idft1p6d 281 5 the the DT cord-022053-idft1p6d 281 6 evaluation evaluation NN cord-022053-idft1p6d 281 7 included include VBD cord-022053-idft1p6d 281 8 two two CD cord-022053-idft1p6d 281 9 S. S. NNP cord-022053-idft1p6d 281 10 agalactiae agalactiae NN cord-022053-idft1p6d 281 11 samples sample NNS cord-022053-idft1p6d 281 12 , , , cord-022053-idft1p6d 281 13 both both DT cord-022053-idft1p6d 281 14 of of IN cord-022053-idft1p6d 281 15 which which WDT cord-022053-idft1p6d 281 16 were be VBD cord-022053-idft1p6d 281 17 correctly correctly RB cord-022053-idft1p6d 281 18 identified identify VBN cord-022053-idft1p6d 281 19 . . . cord-022053-idft1p6d 282 1 106 106 CD cord-022053-idft1p6d 283 1 Since since IN cord-022053-idft1p6d 283 2 FDA FDA NNP cord-022053-idft1p6d 283 3 approval approval NN cord-022053-idft1p6d 283 4 , , , cord-022053-idft1p6d 283 5 one one CD cord-022053-idft1p6d 283 6 US US NNP cord-022053-idft1p6d 283 7 study study NN cord-022053-idft1p6d 283 8 has have VBZ cord-022053-idft1p6d 283 9 been be VBN cord-022053-idft1p6d 283 10 published publish VBN cord-022053-idft1p6d 283 11 on on IN cord-022053-idft1p6d 283 12 the the DT cord-022053-idft1p6d 283 13 performance performance NN cord-022053-idft1p6d 283 14 of of IN cord-022053-idft1p6d 283 15 the the DT cord-022053-idft1p6d 283 16 panel panel NN cord-022053-idft1p6d 283 17 in in IN cord-022053-idft1p6d 283 18 several several JJ cord-022053-idft1p6d 283 19 Texas Texas NNP cord-022053-idft1p6d 283 20 medical medical JJ cord-022053-idft1p6d 283 21 centers center NNS cord-022053-idft1p6d 283 22 . . . cord-022053-idft1p6d 284 1 In in IN cord-022053-idft1p6d 284 2 that that DT cord-022053-idft1p6d 284 3 study study NN cord-022053-idft1p6d 284 4 of of IN cord-022053-idft1p6d 284 5 48 48 CD cord-022053-idft1p6d 284 6 patients patient NNS cord-022053-idft1p6d 284 7 with with IN cord-022053-idft1p6d 284 8 community community NN cord-022053-idft1p6d 284 9 - - HYPH cord-022053-idft1p6d 284 10 acquired acquire VBN cord-022053-idft1p6d 284 11 meningitis meningitis NN cord-022053-idft1p6d 284 12 and and CC cord-022053-idft1p6d 284 13 a a DT cord-022053-idft1p6d 284 14 negative negative JJ cord-022053-idft1p6d 284 15 Gram gram NN cord-022053-idft1p6d 284 16 stain stain NN cord-022053-idft1p6d 284 17 , , , cord-022053-idft1p6d 284 18 the the DT cord-022053-idft1p6d 284 19 FilmArray FilmArray NNP cord-022053-idft1p6d 284 20 detected detect VBD cord-022053-idft1p6d 284 21 two two CD cord-022053-idft1p6d 284 22 samples sample NNS cord-022053-idft1p6d 284 23 with with IN cord-022053-idft1p6d 284 24 bacterial bacterial JJ cord-022053-idft1p6d 284 25 pathogens pathogen NNS cord-022053-idft1p6d 284 26 , , , cord-022053-idft1p6d 284 27 both both CC cord-022053-idft1p6d 284 28 S. S. NNP cord-022053-idft1p6d 284 29 pneumoniae pneumoniae NN cord-022053-idft1p6d 284 30 . . . cord-022053-idft1p6d 285 1 Culture culture NN cord-022053-idft1p6d 285 2 detected detect VBD cord-022053-idft1p6d 285 3 only only RB cord-022053-idft1p6d 285 4 one one CD cord-022053-idft1p6d 285 5 of of IN cord-022053-idft1p6d 285 6 these these DT cord-022053-idft1p6d 285 7 , , , cord-022053-idft1p6d 285 8 although although IN cord-022053-idft1p6d 285 9 the the DT cord-022053-idft1p6d 285 10 other other JJ cord-022053-idft1p6d 285 11 one one NN cord-022053-idft1p6d 285 12 was be VBD cord-022053-idft1p6d 285 13 positive positive JJ cord-022053-idft1p6d 285 14 for for IN cord-022053-idft1p6d 285 15 streptococcal streptococcal JJ cord-022053-idft1p6d 285 16 urinary urinary JJ cord-022053-idft1p6d 285 17 antigen antigen NN cord-022053-idft1p6d 285 18 . . . cord-022053-idft1p6d 286 1 107 107 CD cord-022053-idft1p6d 286 2 Finally finally RB cord-022053-idft1p6d 286 3 , , , cord-022053-idft1p6d 286 4 the the DT cord-022053-idft1p6d 286 5 FilmArray FilmArray NNP cord-022053-idft1p6d 286 6 blood blood NN cord-022053-idft1p6d 286 7 culture culture NN cord-022053-idft1p6d 286 8 identification identification NN cord-022053-idft1p6d 286 9 ( ( -LRB- cord-022053-idft1p6d 286 10 BCID BCID NNP cord-022053-idft1p6d 286 11 ) ) -RRB- cord-022053-idft1p6d 286 12 panel panel NN cord-022053-idft1p6d 286 13 tests test NNS cord-022053-idft1p6d 286 14 for for IN cord-022053-idft1p6d 286 15 an an DT cord-022053-idft1p6d 286 16 array array NN cord-022053-idft1p6d 286 17 of of IN cord-022053-idft1p6d 286 18 19 19 CD cord-022053-idft1p6d 286 19 bacterial bacterial JJ cord-022053-idft1p6d 286 20 targets target NNS cord-022053-idft1p6d 286 21 , , , cord-022053-idft1p6d 286 22 including include VBG cord-022053-idft1p6d 286 23 : : : cord-022053-idft1p6d 286 24 Enterococcus Enterococcus NNP cord-022053-idft1p6d 286 25 , , , cord-022053-idft1p6d 286 26 L. L. NNP cord-022053-idft1p6d 286 27 monocytogenes monocytogenes NNP cord-022053-idft1p6d 286 28 , , , cord-022053-idft1p6d 286 29 SA SA NNP cord-022053-idft1p6d 286 30 , , , cord-022053-idft1p6d 286 31 Streptococcus Streptococcus NNP cord-022053-idft1p6d 286 32 ( ( -LRB- cord-022053-idft1p6d 286 33 multiple multiple NN cord-022053-idft1p6d 286 34 ) ) -RRB- cord-022053-idft1p6d 286 35 , , , cord-022053-idft1p6d 286 36 A. a. NN cord-022053-idft1p6d 286 37 baumannii baumannii NNP cord-022053-idft1p6d 286 38 , , , cord-022053-idft1p6d 286 39 P. P. NNP cord-022053-idft1p6d 286 40 aeruginosa aeruginosa NN cord-022053-idft1p6d 286 41 , , , cord-022053-idft1p6d 286 42 E. E. NNP cord-022053-idft1p6d 286 43 coli coli NNS cord-022053-idft1p6d 286 44 , , , cord-022053-idft1p6d 286 45 and and CC cord-022053-idft1p6d 286 46 K. K. NNP cord-022053-idft1p6d 286 47 pneumoniae pneumoniae NNS cord-022053-idft1p6d 286 48 . . . cord-022053-idft1p6d 287 1 It -PRON- PRP cord-022053-idft1p6d 287 2 also also RB cord-022053-idft1p6d 287 3 tests test VBZ cord-022053-idft1p6d 287 4 for for IN cord-022053-idft1p6d 287 5 five five CD cord-022053-idft1p6d 287 6 species specie NNS cord-022053-idft1p6d 287 7 of of IN cord-022053-idft1p6d 287 8 Candida Candida NNP cord-022053-idft1p6d 287 9 and and CC cord-022053-idft1p6d 287 10 three three CD cord-022053-idft1p6d 287 11 bacterial bacterial JJ cord-022053-idft1p6d 287 12 resistance resistance NN cord-022053-idft1p6d 287 13 genes gene NNS cord-022053-idft1p6d 287 14 : : : cord-022053-idft1p6d 287 15 mecA mecA NNP cord-022053-idft1p6d 287 16 , , , cord-022053-idft1p6d 287 17 vanA vanA NNP cord-022053-idft1p6d 287 18 / / SYM cord-022053-idft1p6d 287 19 B B NNP cord-022053-idft1p6d 287 20 , , , cord-022053-idft1p6d 287 21 and and CC cord-022053-idft1p6d 287 22 kpc kpc NN cord-022053-idft1p6d 287 23 . . . cord-022053-idft1p6d 288 1 It -PRON- PRP cord-022053-idft1p6d 288 2 has have VBZ cord-022053-idft1p6d 288 3 performed perform VBN cord-022053-idft1p6d 288 4 well well RB cord-022053-idft1p6d 288 5 on on IN cord-022053-idft1p6d 288 6 both both CC cord-022053-idft1p6d 288 7 monomicrobial monomicrobial JJ cord-022053-idft1p6d 288 8 and and CC cord-022053-idft1p6d 288 9 polymicrobial polymicrobial JJ cord-022053-idft1p6d 288 10 specimens specimen NNS cord-022053-idft1p6d 288 11 in in IN cord-022053-idft1p6d 288 12 several several JJ cord-022053-idft1p6d 288 13 clinical clinical JJ cord-022053-idft1p6d 288 14 studies study NNS cord-022053-idft1p6d 288 15 . . . cord-022053-idft1p6d 289 1 108 108 CD cord-022053-idft1p6d 289 2 , , , cord-022053-idft1p6d 289 3 109 109 CD cord-022053-idft1p6d 289 4 _SP cord-022053-idft1p6d 290 1 The the DT cord-022053-idft1p6d 290 2 BD BD NNP cord-022053-idft1p6d 290 3 Max Max NNP cord-022053-idft1p6d 290 4 is be VBZ cord-022053-idft1p6d 290 5 a a DT cord-022053-idft1p6d 290 6 sample sample NN cord-022053-idft1p6d 290 7 - - HYPH cord-022053-idft1p6d 290 8 to to IN cord-022053-idft1p6d 290 9 - - HYPH cord-022053-idft1p6d 290 10 result result VB cord-022053-idft1p6d 290 11 real real JJ cord-022053-idft1p6d 290 12 - - HYPH cord-022053-idft1p6d 290 13 time time NN cord-022053-idft1p6d 290 14 PCR pcr NN cord-022053-idft1p6d 290 15 - - HYPH cord-022053-idft1p6d 290 16 based base VBN cord-022053-idft1p6d 290 17 platform platform NN cord-022053-idft1p6d 290 18 . . . cord-022053-idft1p6d 291 1 Amplicons amplicon NNS cord-022053-idft1p6d 291 2 are be VBP cord-022053-idft1p6d 291 3 detected detect VBN cord-022053-idft1p6d 291 4 via via IN cord-022053-idft1p6d 291 5 fluorescent fluorescent JJ cord-022053-idft1p6d 291 6 probes probe NNS cord-022053-idft1p6d 291 7 . . . cord-022053-idft1p6d 292 1 A a DT cord-022053-idft1p6d 292 2 distinguishing distinguishing JJ cord-022053-idft1p6d 292 3 feature feature NN cord-022053-idft1p6d 292 4 is be VBZ cord-022053-idft1p6d 292 5 the the DT cord-022053-idft1p6d 292 6 capability capability NN cord-022053-idft1p6d 292 7 to to TO cord-022053-idft1p6d 292 8 run run VB cord-022053-idft1p6d 292 9 laboratory laboratory NN cord-022053-idft1p6d 292 10 - - HYPH cord-022053-idft1p6d 292 11 developed develop VBN cord-022053-idft1p6d 292 12 tests test NNS cord-022053-idft1p6d 292 13 alongside alongside IN cord-022053-idft1p6d 292 14 FDA FDA NNP cord-022053-idft1p6d 292 15 - - HYPH cord-022053-idft1p6d 292 16 approved approve VBN cord-022053-idft1p6d 292 17 panels panel NNS cord-022053-idft1p6d 292 18 . . . cord-022053-idft1p6d 293 1 Current current JJ cord-022053-idft1p6d 293 2 FDA FDA NNP cord-022053-idft1p6d 293 3 - - HYPH cord-022053-idft1p6d 293 4 approved approve VBN cord-022053-idft1p6d 293 5 assays assay NNS cord-022053-idft1p6d 293 6 include include VBP cord-022053-idft1p6d 293 7 GBS GBS NNP cord-022053-idft1p6d 293 8 ( ( -LRB- cord-022053-idft1p6d 293 9 for for IN cord-022053-idft1p6d 293 10 group group NN cord-022053-idft1p6d 293 11 B B NNP cord-022053-idft1p6d 293 12 Streptococci Streptococci NNP cord-022053-idft1p6d 293 13 ) ) -RRB- cord-022053-idft1p6d 293 14 , , , cord-022053-idft1p6d 293 15 CT CT NNP cord-022053-idft1p6d 293 16 / / SYM cord-022053-idft1p6d 293 17 GC GC NNP cord-022053-idft1p6d 293 18 / / SYM cord-022053-idft1p6d 293 19 TV TV NNP cord-022053-idft1p6d 293 20 ( ( -LRB- cord-022053-idft1p6d 293 21 for for IN cord-022053-idft1p6d 293 22 vaginitis vaginitis NN cord-022053-idft1p6d 293 23 ) ) -RRB- cord-022053-idft1p6d 293 24 , , , cord-022053-idft1p6d 293 25 MRSA MRSA NNP cord-022053-idft1p6d 293 26 XT XT NNP cord-022053-idft1p6d 293 27 ( ( -LRB- cord-022053-idft1p6d 293 28 for for IN cord-022053-idft1p6d 293 29 extended extended JJ cord-022053-idft1p6d 293 30 MRSA MRSA NNP cord-022053-idft1p6d 293 31 coverage coverage NN cord-022053-idft1p6d 293 32 ) ) -RRB- cord-022053-idft1p6d 293 33 , , , cord-022053-idft1p6d 293 34 Cdiff Cdiff NNP cord-022053-idft1p6d 293 35 ( ( -LRB- cord-022053-idft1p6d 293 36 for for IN cord-022053-idft1p6d 293 37 C. C. NNP cord-022053-idft1p6d 293 38 difficile difficile NNP cord-022053-idft1p6d 293 39 ) ) -RRB- cord-022053-idft1p6d 293 40 , , , cord-022053-idft1p6d 293 41 and and CC cord-022053-idft1p6d 293 42 StaffSR StaffSR NNP cord-022053-idft1p6d 293 43 ( ( -LRB- cord-022053-idft1p6d 293 44 for for IN cord-022053-idft1p6d 293 45 Staphylococcus Staphylococcus NNP cord-022053-idft1p6d 293 46 aureas aureas NNP cord-022053-idft1p6d 293 47 and and CC cord-022053-idft1p6d 293 48 MRSA MRSA NNP cord-022053-idft1p6d 293 49 ) ) -RRB- cord-022053-idft1p6d 293 50 . . . cord-022053-idft1p6d 294 1 The the DT cord-022053-idft1p6d 294 2 bacterial bacterial JJ cord-022053-idft1p6d 294 3 panel panel NN cord-022053-idft1p6d 294 4 includes include VBZ cord-022053-idft1p6d 294 5 Salmonella Salmonella NNP cord-022053-idft1p6d 294 6 spp spp NNP cord-022053-idft1p6d 294 7 . . . cord-022053-idft1p6d 295 1 , , , cord-022053-idft1p6d 295 2 Campylobacter Campylobacter NNP cord-022053-idft1p6d 295 3 spp spp NNS cord-022053-idft1p6d 295 4 . . . cord-022053-idft1p6d 296 1 ( ( -LRB- cord-022053-idft1p6d 296 2 jejuni jejuni NNP cord-022053-idft1p6d 296 3 / / SYM cord-022053-idft1p6d 296 4 coli coli NNP cord-022053-idft1p6d 296 5 ) ) -RRB- cord-022053-idft1p6d 296 6 , , , cord-022053-idft1p6d 296 7 Shigellosis Shigellosis NNP cord-022053-idft1p6d 296 8 disease disease NN cord-022053-idft1p6d 296 9 - - HYPH cord-022053-idft1p6d 296 10 causing cause VBG cord-022053-idft1p6d 296 11 agents agent NNS cord-022053-idft1p6d 296 12 ( ( -LRB- cord-022053-idft1p6d 296 13 Shigella Shigella NNP cord-022053-idft1p6d 296 14 spp spp NNS cord-022053-idft1p6d 296 15 . . . cord-022053-idft1p6d 297 1 and and CC cord-022053-idft1p6d 297 2 EIEC EIEC NNP cord-022053-idft1p6d 297 3 ) ) -RRB- cord-022053-idft1p6d 297 4 , , , cord-022053-idft1p6d 297 5 as as RB cord-022053-idft1p6d 297 6 well well RB cord-022053-idft1p6d 297 7 as as IN cord-022053-idft1p6d 298 1 Shiga Shiga NNP cord-022053-idft1p6d 298 2 - - HYPH cord-022053-idft1p6d 298 3 toxin toxin NN cord-022053-idft1p6d 298 4 producing produce VBG cord-022053-idft1p6d 298 5 E. E. NNP cord-022053-idft1p6d 298 6 coli coli NNS cord-022053-idft1p6d 298 7 . . . cord-022053-idft1p6d 299 1 It -PRON- PRP cord-022053-idft1p6d 299 2 has have VBZ cord-022053-idft1p6d 299 3 demonstrated demonstrate VBN cord-022053-idft1p6d 299 4 high high JJ cord-022053-idft1p6d 299 5 sensitivity sensitivity NN cord-022053-idft1p6d 299 6 for for IN cord-022053-idft1p6d 299 7 the the DT cord-022053-idft1p6d 299 8 organisms organism NNS cord-022053-idft1p6d 299 9 in in IN cord-022053-idft1p6d 299 10 its -PRON- PRP$ cord-022053-idft1p6d 299 11 library library NN cord-022053-idft1p6d 299 12 in in IN cord-022053-idft1p6d 299 13 several several JJ cord-022053-idft1p6d 299 14 studies study NNS cord-022053-idft1p6d 299 15 . . . cord-022053-idft1p6d 300 1 [ [ -LRB- cord-022053-idft1p6d 300 2 110 110 CD cord-022053-idft1p6d 300 3 ] ] -RRB- cord-022053-idft1p6d 300 4 [ [ -LRB- cord-022053-idft1p6d 300 5 111 111 CD cord-022053-idft1p6d 300 6 ] ] -RRB- cord-022053-idft1p6d 301 1 [ [ -LRB- cord-022053-idft1p6d 301 2 112 112 CD cord-022053-idft1p6d 301 3 ] ] -RRB- cord-022053-idft1p6d 302 1 The the DT cord-022053-idft1p6d 302 2 parasite parasite NN cord-022053-idft1p6d 302 3 panel panel NN cord-022053-idft1p6d 302 4 includes include VBZ cord-022053-idft1p6d 302 5 the the DT cord-022053-idft1p6d 302 6 three three CD cord-022053-idft1p6d 302 7 most most RBS cord-022053-idft1p6d 302 8 common common JJ cord-022053-idft1p6d 302 9 protist protist NN cord-022053-idft1p6d 302 10 parasites parasite NNS cord-022053-idft1p6d 302 11 in in IN cord-022053-idft1p6d 302 12 humans human NNS cord-022053-idft1p6d 302 13 in in IN cord-022053-idft1p6d 302 14 developed develop VBN cord-022053-idft1p6d 302 15 countries country NNS cord-022053-idft1p6d 302 16 , , , cord-022053-idft1p6d 302 17 including include VBG cord-022053-idft1p6d 302 18 Giardia Giardia NNP cord-022053-idft1p6d 302 19 lamblia lamblia NNP cord-022053-idft1p6d 302 20 , , , cord-022053-idft1p6d 302 21 Cryptosporidium cryptosporidium NN cord-022053-idft1p6d 302 22 , , , cord-022053-idft1p6d 302 23 and and CC cord-022053-idft1p6d 302 24 E. E. NNP cord-022053-idft1p6d 302 25 histolytica histolytica NNP cord-022053-idft1p6d 302 26 , , , cord-022053-idft1p6d 302 27 but but CC cord-022053-idft1p6d 302 28 has have VBZ cord-022053-idft1p6d 302 29 the the DT cord-022053-idft1p6d 302 30 difficult difficult JJ cord-022053-idft1p6d 302 31 challenge challenge NN cord-022053-idft1p6d 302 32 of of IN cord-022053-idft1p6d 302 33 very very RB cord-022053-idft1p6d 302 34 low low JJ cord-022053-idft1p6d 302 35 population population NN cord-022053-idft1p6d 302 36 prevalence prevalence NN cord-022053-idft1p6d 302 37 relative relative JJ cord-022053-idft1p6d 302 38 to to IN cord-022053-idft1p6d 302 39 the the DT cord-022053-idft1p6d 302 40 bacterial bacterial JJ cord-022053-idft1p6d 302 41 assays assay NNS cord-022053-idft1p6d 302 42 , , , cord-022053-idft1p6d 302 43 making make VBG cord-022053-idft1p6d 302 44 cost cost VB cord-022053-idft1p6d 302 45 a a DT cord-022053-idft1p6d 302 46 challenge challenge NN cord-022053-idft1p6d 302 47 over over IN cord-022053-idft1p6d 302 48 other other JJ cord-022053-idft1p6d 302 49 methods method NNS cord-022053-idft1p6d 302 50 for for IN cord-022053-idft1p6d 302 51 uptake uptake NN cord-022053-idft1p6d 302 52 . . . cord-022053-idft1p6d 303 1 113 113 CD cord-022053-idft1p6d 303 2 Verigene Verigene NNP cord-022053-idft1p6d 303 3 is be VBZ cord-022053-idft1p6d 303 4 another another DT cord-022053-idft1p6d 303 5 widely widely RB cord-022053-idft1p6d 303 6 used use VBN cord-022053-idft1p6d 303 7 multiplex multiplex NN cord-022053-idft1p6d 303 8 PCR PCR NNP cord-022053-idft1p6d 303 9 platform platform NN cord-022053-idft1p6d 303 10 incorporating incorporate VBG cord-022053-idft1p6d 303 11 PCR PCR NNP cord-022053-idft1p6d 303 12 of of IN cord-022053-idft1p6d 303 13 multiple multiple JJ cord-022053-idft1p6d 303 14 viral viral JJ cord-022053-idft1p6d 303 15 and and CC cord-022053-idft1p6d 303 16 bacterial bacterial JJ cord-022053-idft1p6d 303 17 targets target NNS cord-022053-idft1p6d 303 18 followed follow VBN cord-022053-idft1p6d 303 19 by by IN cord-022053-idft1p6d 303 20 hybridization hybridization NN cord-022053-idft1p6d 303 21 to to IN cord-022053-idft1p6d 303 22 a a DT cord-022053-idft1p6d 303 23 solid solid JJ cord-022053-idft1p6d 303 24 - - HYPH cord-022053-idft1p6d 303 25 phase phase NN cord-022053-idft1p6d 303 26 microarray microarray NN cord-022053-idft1p6d 303 27 . . . cord-022053-idft1p6d 304 1 Detection detection NN cord-022053-idft1p6d 304 2 occurs occur VBZ cord-022053-idft1p6d 304 3 via via IN cord-022053-idft1p6d 304 4 sandwich sandwich NN cord-022053-idft1p6d 304 5 hybridization hybridization NN cord-022053-idft1p6d 304 6 with with IN cord-022053-idft1p6d 304 7 another another DT cord-022053-idft1p6d 304 8 analyte analyte RB cord-022053-idft1p6d 304 9 - - HYPH cord-022053-idft1p6d 304 10 specific specific JJ cord-022053-idft1p6d 304 11 probe probe NN cord-022053-idft1p6d 304 12 bound bind VBN cord-022053-idft1p6d 304 13 to to IN cord-022053-idft1p6d 304 14 a a DT cord-022053-idft1p6d 304 15 gold gold JJ cord-022053-idft1p6d 304 16 nanoparticle nanoparticle NN cord-022053-idft1p6d 304 17 . . . cord-022053-idft1p6d 305 1 The the DT cord-022053-idft1p6d 305 2 signal signal NN cord-022053-idft1p6d 305 3 is be VBZ cord-022053-idft1p6d 305 4 amplified amplify VBN cord-022053-idft1p6d 305 5 via via IN cord-022053-idft1p6d 305 6 deposition deposition NN cord-022053-idft1p6d 305 7 of of IN cord-022053-idft1p6d 305 8 colloidal colloidal JJ cord-022053-idft1p6d 305 9 silver silver NN cord-022053-idft1p6d 305 10 that that WDT cord-022053-idft1p6d 305 11 is be VBZ cord-022053-idft1p6d 305 12 then then RB cord-022053-idft1p6d 305 13 detected detect VBN cord-022053-idft1p6d 305 14 by by IN cord-022053-idft1p6d 305 15 light light JJ cord-022053-idft1p6d 305 16 diffraction diffraction NN cord-022053-idft1p6d 305 17 . . . cord-022053-idft1p6d 306 1 Verigene verigene JJ cord-022053-idft1p6d 306 2 organisms organism NNS cord-022053-idft1p6d 306 3 per per IN cord-022053-idft1p6d 306 4 milliliter milliliter NN cord-022053-idft1p6d 306 5 . . . cord-022053-idft1p6d 307 1 90 90 CD cord-022053-idft1p6d 308 1 There there EX cord-022053-idft1p6d 308 2 is be VBZ cord-022053-idft1p6d 308 3 a a DT cord-022053-idft1p6d 308 4 great great JJ cord-022053-idft1p6d 308 5 need need NN cord-022053-idft1p6d 308 6 for for IN cord-022053-idft1p6d 308 7 rapid rapid JJ cord-022053-idft1p6d 308 8 molecular molecular JJ cord-022053-idft1p6d 308 9 diagnostics diagnostic NNS cord-022053-idft1p6d 308 10 in in IN cord-022053-idft1p6d 308 11 this this DT cord-022053-idft1p6d 308 12 area area NN cord-022053-idft1p6d 308 13 . . . cord-022053-idft1p6d 309 1 In in IN cord-022053-idft1p6d 309 2 anatomic anatomic JJ cord-022053-idft1p6d 309 3 pathology pathology NN cord-022053-idft1p6d 309 4 , , , cord-022053-idft1p6d 309 5 sample sample NN cord-022053-idft1p6d 309 6 with with IN cord-022053-idft1p6d 309 7 culture culture NN cord-022053-idft1p6d 309 8 and/or and/or CC cord-022053-idft1p6d 309 9 morphology morphology NN cord-022053-idft1p6d 309 10 with with IN cord-022053-idft1p6d 309 11 special special JJ cord-022053-idft1p6d 309 12 stains stain NNS cord-022053-idft1p6d 309 13 and/or and/or CC cord-022053-idft1p6d 309 14 IHC IHC NNP cord-022053-idft1p6d 309 15 can can MD cord-022053-idft1p6d 309 16 resolve resolve VB cord-022053-idft1p6d 309 17 many many JJ cord-022053-idft1p6d 309 18 of of IN cord-022053-idft1p6d 309 19 these these DT cord-022053-idft1p6d 309 20 infections infection NNS cord-022053-idft1p6d 309 21 ; ; : cord-022053-idft1p6d 309 22 however however RB cord-022053-idft1p6d 309 23 , , , cord-022053-idft1p6d 309 24 optimal optimal JJ cord-022053-idft1p6d 309 25 patient patient NN cord-022053-idft1p6d 309 26 care care NN cord-022053-idft1p6d 309 27 and and CC cord-022053-idft1p6d 309 28 best good JJS cord-022053-idft1p6d 309 29 outcomes outcome NNS cord-022053-idft1p6d 309 30 occur occur VBP cord-022053-idft1p6d 309 31 in in IN cord-022053-idft1p6d 309 32 those those DT cord-022053-idft1p6d 309 33 patients patient NNS cord-022053-idft1p6d 309 34 who who WP cord-022053-idft1p6d 309 35 can can MD cord-022053-idft1p6d 309 36 be be VB cord-022053-idft1p6d 309 37 diagnosed diagnose VBN cord-022053-idft1p6d 309 38 early early RB cord-022053-idft1p6d 309 39 with with IN cord-022053-idft1p6d 309 40 these these DT cord-022053-idft1p6d 309 41 panels panel NNS cord-022053-idft1p6d 309 42 and and CC cord-022053-idft1p6d 309 43 not not RB cord-022053-idft1p6d 309 44 require require VB cord-022053-idft1p6d 309 45 an an DT cord-022053-idft1p6d 309 46 invasive invasive JJ cord-022053-idft1p6d 309 47 biopsy biopsy NN cord-022053-idft1p6d 309 48 . . . cord-022053-idft1p6d 310 1 Sepsis sepsis NN cord-022053-idft1p6d 310 2 continues continue VBZ cord-022053-idft1p6d 310 3 to to TO cord-022053-idft1p6d 310 4 be be VB cord-022053-idft1p6d 310 5 a a DT cord-022053-idft1p6d 310 6 tremendous tremendous JJ cord-022053-idft1p6d 310 7 cause cause NN cord-022053-idft1p6d 310 8 of of IN cord-022053-idft1p6d 310 9 mortality mortality NN cord-022053-idft1p6d 310 10 , , , cord-022053-idft1p6d 310 11 ranking rank VBG cord-022053-idft1p6d 310 12 as as IN cord-022053-idft1p6d 310 13 one one CD cord-022053-idft1p6d 310 14 of of IN cord-022053-idft1p6d 310 15 the the DT cord-022053-idft1p6d 310 16 top top JJ cord-022053-idft1p6d 310 17 10 10 CD cord-022053-idft1p6d 310 18 causes cause NNS cord-022053-idft1p6d 310 19 of of IN cord-022053-idft1p6d 310 20 death death NN cord-022053-idft1p6d 310 21 in in IN cord-022053-idft1p6d 310 22 the the DT cord-022053-idft1p6d 310 23 United United NNP cord-022053-idft1p6d 310 24 States States NNP cord-022053-idft1p6d 310 25 . . . cord-022053-idft1p6d 311 1 93 93 CD cord-022053-idft1p6d 312 1 Organisms organism NNS cord-022053-idft1p6d 312 2 commonly commonly RB cord-022053-idft1p6d 312 3 associated associate VBN cord-022053-idft1p6d 312 4 with with IN cord-022053-idft1p6d 312 5 bloodstream bloodstream NN cord-022053-idft1p6d 312 6 infections infection NNS cord-022053-idft1p6d 312 7 include include VBP cord-022053-idft1p6d 312 8 SA SA NNP cord-022053-idft1p6d 312 9 , , , cord-022053-idft1p6d 312 10 E. E. NNP cord-022053-idft1p6d 312 11 coli coli NNS cord-022053-idft1p6d 312 12 , , , cord-022053-idft1p6d 313 1 Enterococcus Enterococcus NNP cord-022053-idft1p6d 313 2 spp spp NNP cord-022053-idft1p6d 313 3 . . . cord-022053-idft1p6d 314 1 , , , cord-022053-idft1p6d 314 2 K. K. NNP cord-022053-idft1p6d 314 3 pneumoniae pneumoniae NN cord-022053-idft1p6d 314 4 , , , cord-022053-idft1p6d 314 5 CNS CNS NNP cord-022053-idft1p6d 314 6 , , , cord-022053-idft1p6d 314 7 P. P. NNP cord-022053-idft1p6d 314 8 aeruginosa aeruginosa NN cord-022053-idft1p6d 314 9 , , , cord-022053-idft1p6d 314 10 Candida Candida NNP cord-022053-idft1p6d 314 11 albicans albican NNS cord-022053-idft1p6d 314 12 , , , cord-022053-idft1p6d 314 13 E. E. NNP cord-022053-idft1p6d 314 14 cloacae cloacae NN cord-022053-idft1p6d 314 15 , , , cord-022053-idft1p6d 314 16 and and CC cord-022053-idft1p6d 314 17 Serratia Serratia NNP cord-022053-idft1p6d 314 18 marcescens marcescen NNS cord-022053-idft1p6d 314 19 . . . cord-022053-idft1p6d 314 20 94 94 CD cord-022053-idft1p6d 315 1 The the DT cord-022053-idft1p6d 315 2 current current JJ cord-022053-idft1p6d 315 3 gold gold NN cord-022053-idft1p6d 315 4 standard standard NN cord-022053-idft1p6d 315 5 for for IN cord-022053-idft1p6d 315 6 diagnosis diagnosis NN cord-022053-idft1p6d 315 7 is be VBZ cord-022053-idft1p6d 315 8 culture culture NN cord-022053-idft1p6d 315 9 , , , cord-022053-idft1p6d 315 10 with with IN cord-022053-idft1p6d 315 11 several several JJ cord-022053-idft1p6d 315 12 automated automate VBN cord-022053-idft1p6d 315 13 systems system NNS cord-022053-idft1p6d 315 14 ( ( -LRB- cord-022053-idft1p6d 315 15 such such JJ cord-022053-idft1p6d 315 16 as as IN cord-022053-idft1p6d 315 17 the the DT cord-022053-idft1p6d 315 18 BacT BacT NNP cord-022053-idft1p6d 315 19 / / SYM cord-022053-idft1p6d 315 20 Alert Alert NNP cord-022053-idft1p6d 315 21 [ [ -LRB- cord-022053-idft1p6d 315 22 BioMérieux BioMérieux NNP cord-022053-idft1p6d 315 23 Inc. Inc. NNP cord-022053-idft1p6d 315 24 ] ] -RRB- cord-022053-idft1p6d 315 25 ) ) -RRB- cord-022053-idft1p6d 315 26 available available JJ cord-022053-idft1p6d 315 27 to to IN cord-022053-idft1p6d 315 28 clinical clinical JJ cord-022053-idft1p6d 315 29 laboratories laboratory NNS cord-022053-idft1p6d 315 30 . . . cord-022053-idft1p6d 316 1 95 95 CD cord-022053-idft1p6d 317 1 Although although IN cord-022053-idft1p6d 317 2 these these DT cord-022053-idft1p6d 317 3 systems system NNS cord-022053-idft1p6d 317 4 are be VBP cord-022053-idft1p6d 317 5 quite quite RB cord-022053-idft1p6d 317 6 sensitive sensitive JJ cord-022053-idft1p6d 317 7 , , , cord-022053-idft1p6d 317 8 approximately approximately RB cord-022053-idft1p6d 317 9 only only RB cord-022053-idft1p6d 317 10 one one CD cord-022053-idft1p6d 317 11 - - HYPH cord-022053-idft1p6d 317 12 third third NN cord-022053-idft1p6d 317 13 of of IN cord-022053-idft1p6d 317 14 patients patient NNS cord-022053-idft1p6d 317 15 with with IN cord-022053-idft1p6d 317 16 sepsis sepsis NN cord-022053-idft1p6d 317 17 have have VBP cord-022053-idft1p6d 317 18 positive positive JJ cord-022053-idft1p6d 317 19 cultures culture NNS cord-022053-idft1p6d 317 20 . . . cord-022053-idft1p6d 318 1 96 96 CD cord-022053-idft1p6d 318 2 Some some DT cord-022053-idft1p6d 318 3 of of IN cord-022053-idft1p6d 318 4 this this DT cord-022053-idft1p6d 318 5 lack lack NN cord-022053-idft1p6d 318 6 of of IN cord-022053-idft1p6d 318 7 sensitivity sensitivity NN cord-022053-idft1p6d 318 8 may may MD cord-022053-idft1p6d 318 9 be be VB cord-022053-idft1p6d 318 10 due due JJ cord-022053-idft1p6d 318 11 to to IN cord-022053-idft1p6d 318 12 pretreatment pretreatment NN cord-022053-idft1p6d 318 13 with with IN cord-022053-idft1p6d 318 14 antibiotics antibiotic NNS cord-022053-idft1p6d 318 15 , , , cord-022053-idft1p6d 318 16 and and CC cord-022053-idft1p6d 318 17 some some DT cord-022053-idft1p6d 318 18 of of IN cord-022053-idft1p6d 318 19 it -PRON- PRP cord-022053-idft1p6d 318 20 may may MD cord-022053-idft1p6d 318 21 be be VB cord-022053-idft1p6d 318 22 due due JJ cord-022053-idft1p6d 318 23 to to IN cord-022053-idft1p6d 318 24 the the DT cord-022053-idft1p6d 318 25 low low JJ cord-022053-idft1p6d 318 26 numbers number NNS cord-022053-idft1p6d 318 27 of of IN cord-022053-idft1p6d 318 28 organisms organism NNS cord-022053-idft1p6d 318 29 present present JJ cord-022053-idft1p6d 318 30 in in IN cord-022053-idft1p6d 318 31 many many JJ cord-022053-idft1p6d 318 32 clinically clinically RB cord-022053-idft1p6d 318 33 significant significant JJ cord-022053-idft1p6d 318 34 bacteremias bacteremia NNS cord-022053-idft1p6d 318 35 . . . cord-022053-idft1p6d 319 1 97 97 CD cord-022053-idft1p6d 320 1 In in IN cord-022053-idft1p6d 320 2 addition addition NN cord-022053-idft1p6d 320 3 to to IN cord-022053-idft1p6d 320 4 sensitivity sensitivity NN cord-022053-idft1p6d 320 5 , , , cord-022053-idft1p6d 320 6 speed speed NN cord-022053-idft1p6d 320 7 is be VBZ cord-022053-idft1p6d 320 8 also also RB cord-022053-idft1p6d 320 9 a a DT cord-022053-idft1p6d 320 10 major major JJ cord-022053-idft1p6d 320 11 issue issue NN cord-022053-idft1p6d 320 12 . . . cord-022053-idft1p6d 321 1 The the DT cord-022053-idft1p6d 321 2 rapid rapid JJ cord-022053-idft1p6d 321 3 diagnosis diagnosis NN cord-022053-idft1p6d 321 4 of of IN cord-022053-idft1p6d 321 5 bloodstream bloodstream NN cord-022053-idft1p6d 321 6 infections infection NNS cord-022053-idft1p6d 321 7 is be VBZ cord-022053-idft1p6d 321 8 critical critical JJ cord-022053-idft1p6d 321 9 for for IN cord-022053-idft1p6d 321 10 patient patient JJ cord-022053-idft1p6d 321 11 outcomes outcome NNS cord-022053-idft1p6d 321 12 , , , cord-022053-idft1p6d 321 13 with with IN cord-022053-idft1p6d 321 14 estimates estimate NNS cord-022053-idft1p6d 321 15 of of IN cord-022053-idft1p6d 321 16 a a DT cord-022053-idft1p6d 321 17 7.6 7.6 CD cord-022053-idft1p6d 321 18 % % NN cord-022053-idft1p6d 321 19 decrease decrease NN cord-022053-idft1p6d 321 20 in in IN cord-022053-idft1p6d 321 21 survival survival NN cord-022053-idft1p6d 321 22 for for IN cord-022053-idft1p6d 321 23 every every DT cord-022053-idft1p6d 321 24 hour hour NN cord-022053-idft1p6d 321 25 that that WDT cord-022053-idft1p6d 321 26 appropriate appropriate JJ cord-022053-idft1p6d 321 27 antimicrobials antimicrobial NNS cord-022053-idft1p6d 321 28 are be VBP cord-022053-idft1p6d 321 29 delayed delay VBN cord-022053-idft1p6d 321 30 after after IN cord-022053-idft1p6d 321 31 the the DT cord-022053-idft1p6d 321 32 onset onset NN cord-022053-idft1p6d 321 33 of of IN cord-022053-idft1p6d 321 34 hypotension hypotension NN cord-022053-idft1p6d 321 35 . . . cord-022053-idft1p6d 322 1 98 98 CD cord-022053-idft1p6d 323 1 The the DT cord-022053-idft1p6d 323 2 need need NN cord-022053-idft1p6d 323 3 for for IN cord-022053-idft1p6d 323 4 sensitive sensitive JJ cord-022053-idft1p6d 323 5 , , , cord-022053-idft1p6d 323 6 fast fast JJ cord-022053-idft1p6d 323 7 detection detection NN cord-022053-idft1p6d 323 8 , , , cord-022053-idft1p6d 323 9 ideally ideally RB cord-022053-idft1p6d 323 10 accompanied accompany VBN cord-022053-idft1p6d 323 11 by by IN cord-022053-idft1p6d 323 12 some some DT cord-022053-idft1p6d 323 13 assessment assessment NN cord-022053-idft1p6d 323 14 of of IN cord-022053-idft1p6d 323 15 antibiotic antibiotic JJ cord-022053-idft1p6d 323 16 resistance resistance NN cord-022053-idft1p6d 323 17 determinants determinant NNS cord-022053-idft1p6d 323 18 , , , cord-022053-idft1p6d 323 19 has have VBZ cord-022053-idft1p6d 323 20 inspired inspire VBN cord-022053-idft1p6d 323 21 a a DT cord-022053-idft1p6d 323 22 number number NN cord-022053-idft1p6d 323 23 of of IN cord-022053-idft1p6d 323 24 new new JJ cord-022053-idft1p6d 323 25 technologies technology NNS cord-022053-idft1p6d 323 26 geared gear VBN cord-022053-idft1p6d 323 27 towards towards IN cord-022053-idft1p6d 323 28 improved improved JJ cord-022053-idft1p6d 323 29 speed speed NN cord-022053-idft1p6d 323 30 and and CC cord-022053-idft1p6d 323 31 sensitivity sensitivity NN cord-022053-idft1p6d 323 32 of of IN cord-022053-idft1p6d 323 33 blood blood NN cord-022053-idft1p6d 323 34 culture culture NN cord-022053-idft1p6d 323 35 diagnostics diagnostic NNS cord-022053-idft1p6d 323 36 . . . cord-022053-idft1p6d 324 1 Several several JJ cord-022053-idft1p6d 324 2 of of IN cord-022053-idft1p6d 324 3 these these DT cord-022053-idft1p6d 324 4 have have VBP cord-022053-idft1p6d 324 5 been be VBN cord-022053-idft1p6d 324 6 reviewed review VBN cord-022053-idft1p6d 324 7 . . . cord-022053-idft1p6d 325 1 [ [ -LRB- cord-022053-idft1p6d 325 2 99 99 CD cord-022053-idft1p6d 325 3 ] ] -RRB- cord-022053-idft1p6d 325 4 [ [ -LRB- cord-022053-idft1p6d 325 5 100 100 CD cord-022053-idft1p6d 325 6 ] ] -RRB- cord-022053-idft1p6d 325 7 [ [ -LRB- cord-022053-idft1p6d 325 8 101 101 CD cord-022053-idft1p6d 325 9 ] ] -RRB- cord-022053-idft1p6d 326 1 Platforms platform NNS cord-022053-idft1p6d 326 2 and and CC cord-022053-idft1p6d 326 3 Technologies Technologies NNPS cord-022053-idft1p6d 326 4 FilmArray FilmArray NNP cord-022053-idft1p6d 326 5 ( ( -LRB- cord-022053-idft1p6d 326 6 BioFire BioFire NNP cord-022053-idft1p6d 326 7 / / SYM cord-022053-idft1p6d 326 8 BioMérieux BioMérieux NNP cord-022053-idft1p6d 326 9 ) ) -RRB- cord-022053-idft1p6d 327 1 The the DT cord-022053-idft1p6d 327 2 FilmArray FilmArray NNP cord-022053-idft1p6d 327 3 system system NN cord-022053-idft1p6d 327 4 consists consist VBZ cord-022053-idft1p6d 327 5 of of IN cord-022053-idft1p6d 327 6 nested nest VBN cord-022053-idft1p6d 327 7 PCR PCR NNP cord-022053-idft1p6d 327 8 followed follow VBN cord-022053-idft1p6d 327 9 by by IN cord-022053-idft1p6d 327 10 highresolution highresolution NNP cord-022053-idft1p6d 327 11 melt melt VB cord-022053-idft1p6d 327 12 curve curve NN cord-022053-idft1p6d 327 13 analysis analysis NN cord-022053-idft1p6d 327 14 . . . cord-022053-idft1p6d 328 1 102 102 CD cord-022053-idft1p6d 328 2 All all DT cord-022053-idft1p6d 328 3 steps step NNS cord-022053-idft1p6d 328 4 of of IN cord-022053-idft1p6d 328 5 the the DT cord-022053-idft1p6d 328 6 assay assay NN cord-022053-idft1p6d 328 7 , , , cord-022053-idft1p6d 328 8 from from IN cord-022053-idft1p6d 328 9 cell cell NN cord-022053-idft1p6d 328 10 lysis lysis NN cord-022053-idft1p6d 328 11 to to IN cord-022053-idft1p6d 328 12 the the DT cord-022053-idft1p6d 328 13 final final JJ cord-022053-idft1p6d 328 14 analysis analysis NN cord-022053-idft1p6d 328 15 , , , cord-022053-idft1p6d 328 16 take take VB cord-022053-idft1p6d 328 17 place place NN cord-022053-idft1p6d 328 18 within within IN cord-022053-idft1p6d 328 19 a a DT cord-022053-idft1p6d 328 20 pouch pouch NN cord-022053-idft1p6d 328 21 containing contain VBG cord-022053-idft1p6d 328 22 freeze freeze NN cord-022053-idft1p6d 328 23 - - HYPH cord-022053-idft1p6d 328 24 dried dry VBN cord-022053-idft1p6d 328 25 reagents reagent NNS cord-022053-idft1p6d 328 26 that that WDT cord-022053-idft1p6d 328 27 can can MD cord-022053-idft1p6d 328 28 be be VB cord-022053-idft1p6d 328 29 stored store VBN cord-022053-idft1p6d 328 30 at at IN cord-022053-idft1p6d 328 31 room room NN cord-022053-idft1p6d 328 32 temperature temperature NN cord-022053-idft1p6d 328 33 . . . cord-022053-idft1p6d 329 1 FilmArray FilmArray NNP cord-022053-idft1p6d 329 2 has have VBZ cord-022053-idft1p6d 329 3 a a DT cord-022053-idft1p6d 329 4 short short JJ cord-022053-idft1p6d 329 5 TAT tat NN cord-022053-idft1p6d 329 6 of of IN cord-022053-idft1p6d 329 7 approximately approximately RB cord-022053-idft1p6d 329 8 1 1 CD cord-022053-idft1p6d 329 9 hour hour NN cord-022053-idft1p6d 329 10 . . . cord-022053-idft1p6d 330 1 Disadvantages disadvantage NNS cord-022053-idft1p6d 330 2 of of IN cord-022053-idft1p6d 330 3 the the DT cord-022053-idft1p6d 330 4 system system NN cord-022053-idft1p6d 330 5 include include VBP cord-022053-idft1p6d 330 6 the the DT cord-022053-idft1p6d 330 7 relatively relatively RB cord-022053-idft1p6d 330 8 high high JJ cord-022053-idft1p6d 330 9 price price NN cord-022053-idft1p6d 330 10 of of IN cord-022053-idft1p6d 330 11 the the DT cord-022053-idft1p6d 330 12 pouches pouch NNS cord-022053-idft1p6d 330 13 and and CC cord-022053-idft1p6d 330 14 restriction restriction NN cord-022053-idft1p6d 330 15 of of IN cord-022053-idft1p6d 330 16 the the DT cord-022053-idft1p6d 330 17 platform platform NN cord-022053-idft1p6d 330 18 to to IN cord-022053-idft1p6d 330 19 one one CD cord-022053-idft1p6d 330 20 test test NN cord-022053-idft1p6d 330 21 at at IN cord-022053-idft1p6d 330 22 a a DT cord-022053-idft1p6d 330 23 time time NN cord-022053-idft1p6d 330 24 . . . cord-022053-idft1p6d 331 1 Laboratories laboratory NNS cord-022053-idft1p6d 331 2 must must MD cord-022053-idft1p6d 331 3 purchase purchase VB cord-022053-idft1p6d 331 4 multiple multiple JJ cord-022053-idft1p6d 331 5 FilmArray FilmArray NNP cord-022053-idft1p6d 331 6 platforms platform NNS cord-022053-idft1p6d 331 7 if if IN cord-022053-idft1p6d 331 8 they -PRON- PRP cord-022053-idft1p6d 331 9 desire desire VBP cord-022053-idft1p6d 331 10 to to TO cord-022053-idft1p6d 331 11 run run VB cord-022053-idft1p6d 331 12 tests test NNS cord-022053-idft1p6d 331 13 in in IN cord-022053-idft1p6d 331 14 parallel parallel NN cord-022053-idft1p6d 331 15 . . . cord-022053-idft1p6d 332 1 The the DT cord-022053-idft1p6d 332 2 FilmArray FilmArray NNP cord-022053-idft1p6d 332 3 panel panel NN cord-022053-idft1p6d 332 4 was be VBD cord-022053-idft1p6d 332 5 the the DT cord-022053-idft1p6d 332 6 first first JJ cord-022053-idft1p6d 332 7 FDA FDA NNP cord-022053-idft1p6d 332 8 - - HYPH cord-022053-idft1p6d 332 9 approved approve VBN cord-022053-idft1p6d 332 10 RP RP NNP cord-022053-idft1p6d 332 11 to to TO cord-022053-idft1p6d 332 12 include include VB cord-022053-idft1p6d 332 13 bacterial bacterial JJ cord-022053-idft1p6d 332 14 pathogens pathogen NNS cord-022053-idft1p6d 332 15 , , , cord-022053-idft1p6d 332 16 covering cover VBG cord-022053-idft1p6d 332 17 B. B. NNP cord-022053-idft1p6d 332 18 pertussis pertussis NN cord-022053-idft1p6d 332 19 , , , cord-022053-idft1p6d 332 20 C. C. NNP cord-022053-idft1p6d 332 21 pneumoniae pneumoniae NN cord-022053-idft1p6d 332 22 , , , cord-022053-idft1p6d 332 23 and and CC cord-022053-idft1p6d 332 24 M. M. NNP cord-022053-idft1p6d 332 25 pneumoniae pneumoniae NN cord-022053-idft1p6d 332 26 , , , cord-022053-idft1p6d 332 27 along along IN cord-022053-idft1p6d 332 28 with with IN cord-022053-idft1p6d 332 29 18 18 CD cord-022053-idft1p6d 332 30 common common JJ cord-022053-idft1p6d 332 31 respiratory respiratory JJ cord-022053-idft1p6d 332 32 viruses virus NNS cord-022053-idft1p6d 332 33 . . . cord-022053-idft1p6d 333 1 102 102 CD cord-022053-idft1p6d 334 1 For for IN cord-022053-idft1p6d 334 2 GI GI NNP cord-022053-idft1p6d 334 3 testing testing NN cord-022053-idft1p6d 334 4 , , , cord-022053-idft1p6d 334 5 the the DT cord-022053-idft1p6d 334 6 FilmArray FilmArray NNP cord-022053-idft1p6d 334 7 is be VBZ cord-022053-idft1p6d 334 8 the the DT cord-022053-idft1p6d 334 9 most most RBS cord-022053-idft1p6d 334 10 comprehensive comprehensive JJ cord-022053-idft1p6d 334 11 of of IN cord-022053-idft1p6d 334 12 the the DT cord-022053-idft1p6d 334 13 current current JJ cord-022053-idft1p6d 334 14 FDA FDA NNP cord-022053-idft1p6d 334 15 - - HYPH cord-022053-idft1p6d 334 16 approved approve VBN cord-022053-idft1p6d 334 17 panels panel NNS cord-022053-idft1p6d 334 18 , , , cord-022053-idft1p6d 334 19 covering cover VBG cord-022053-idft1p6d 334 20 an an DT cord-022053-idft1p6d 334 21 array array NN cord-022053-idft1p6d 334 22 of of IN cord-022053-idft1p6d 334 23 22 22 CD cord-022053-idft1p6d 334 24 bacteria bacteria NNS cord-022053-idft1p6d 334 25 , , , cord-022053-idft1p6d 334 26 viral viral JJ cord-022053-idft1p6d 334 27 , , , cord-022053-idft1p6d 334 28 and and CC cord-022053-idft1p6d 334 29 parasitic parasitic JJ cord-022053-idft1p6d 334 30 targets target NNS cord-022053-idft1p6d 334 31 , , , cord-022053-idft1p6d 334 32 including include VBG cord-022053-idft1p6d 334 33 the the DT cord-022053-idft1p6d 334 34 common common JJ cord-022053-idft1p6d 334 35 agents agent NNS cord-022053-idft1p6d 334 36 listed list VBN cord-022053-idft1p6d 334 37 above above RB cord-022053-idft1p6d 334 38 , , , cord-022053-idft1p6d 334 39 as as RB cord-022053-idft1p6d 334 40 well well RB cord-022053-idft1p6d 334 41 as as IN cord-022053-idft1p6d 334 42 Plesiomonas Plesiomonas NNP cord-022053-idft1p6d 334 43 shigelloides shigelloide NNS cord-022053-idft1p6d 334 44 , , , cord-022053-idft1p6d 334 45 Yersinia Yersinia NNP cord-022053-idft1p6d 334 46 enterocolitica enterocolitica NNP cord-022053-idft1p6d 334 47 , , , cord-022053-idft1p6d 334 48 and and CC cord-022053-idft1p6d 334 49 several several JJ cord-022053-idft1p6d 334 50 species specie NNS cord-022053-idft1p6d 334 51 of of IN cord-022053-idft1p6d 334 52 Vibrio vibrio NN cord-022053-idft1p6d 334 53 . . . cord-022053-idft1p6d 335 1 It -PRON- PRP cord-022053-idft1p6d 335 2 can can MD cord-022053-idft1p6d 335 3 also also RB cord-022053-idft1p6d 335 4 differentiate differentiate VB cord-022053-idft1p6d 335 5 between between IN cord-022053-idft1p6d 335 6 enteroaggregative enteroaggregative NNP cord-022053-idft1p6d 335 7 , , , cord-022053-idft1p6d 335 8 enteropathogenic enteropathogenic NNP cord-022053-idft1p6d 335 9 , , , cord-022053-idft1p6d 335 10 enterotoxigenic enterotoxigenic NNP cord-022053-idft1p6d 335 11 , , , cord-022053-idft1p6d 335 12 Shiga Shiga NNP cord-022053-idft1p6d 335 13 toxin toxin NN cord-022053-idft1p6d 335 14 - - HYPH cord-022053-idft1p6d 335 15 producing produce VBG cord-022053-idft1p6d 335 16 , , , cord-022053-idft1p6d 335 17 and and CC cord-022053-idft1p6d 335 18 enteroinvasive enteroinvasive JJ cord-022053-idft1p6d 335 19 E. E. NNP cord-022053-idft1p6d 335 20 coli coli NNS cord-022053-idft1p6d 335 21 ( ( -LRB- cord-022053-idft1p6d 335 22 EIEC EIEC NNP cord-022053-idft1p6d 335 23 ) ) -RRB- cord-022053-idft1p6d 335 24 . . . cord-022053-idft1p6d 336 1 Studies study NNS cord-022053-idft1p6d 336 2 have have VBP cord-022053-idft1p6d 336 3 shown show VBN cord-022053-idft1p6d 336 4 a a DT cord-022053-idft1p6d 336 5 sensitivity sensitivity NN cord-022053-idft1p6d 336 6 of of IN cord-022053-idft1p6d 336 7 95.9 95.9 CD cord-022053-idft1p6d 336 8 % % NN cord-022053-idft1p6d 336 9 to to IN cord-022053-idft1p6d 336 10 100 100 CD cord-022053-idft1p6d 336 11 % % NN cord-022053-idft1p6d 336 12 and and CC cord-022053-idft1p6d 336 13 a a DT cord-022053-idft1p6d 336 14 specificity specificity NN cord-022053-idft1p6d 336 15 of of IN cord-022053-idft1p6d 336 16 96.6 96.6 CD cord-022053-idft1p6d 336 17 % % NN cord-022053-idft1p6d 336 18 to to TO cord-022053-idft1p6d 336 19 100 100 CD cord-022053-idft1p6d 336 20 % % NN cord-022053-idft1p6d 336 21 for for IN cord-022053-idft1p6d 336 22 bacterial bacterial JJ cord-022053-idft1p6d 336 23 pathogens pathogen NNS cord-022053-idft1p6d 336 24 . . . cord-022053-idft1p6d 337 1 103 103 CD cord-022053-idft1p6d 337 2 , , , cord-022053-idft1p6d 337 3 104 104 CD cord-022053-idft1p6d 337 4 In in IN cord-022053-idft1p6d 337 5 many many JJ cord-022053-idft1p6d 337 6 cases case NNS cord-022053-idft1p6d 337 7 the the DT cord-022053-idft1p6d 337 8 FilmArray FilmArray NNP cord-022053-idft1p6d 337 9 detected detect VBD cord-022053-idft1p6d 337 10 pathogens pathogen NNS cord-022053-idft1p6d 337 11 in in IN cord-022053-idft1p6d 337 12 samples sample NNS cord-022053-idft1p6d 337 13 that that WDT cord-022053-idft1p6d 337 14 were be VBD cord-022053-idft1p6d 337 15 negative negative JJ cord-022053-idft1p6d 337 16 and and CC cord-022053-idft1p6d 337 17 was be VBD cord-022053-idft1p6d 337 18 far far RB cord-022053-idft1p6d 337 19 more more RBR cord-022053-idft1p6d 337 20 likely likely JJ cord-022053-idft1p6d 337 21 to to TO cord-022053-idft1p6d 337 22 diagnose diagnose VB cord-022053-idft1p6d 337 23 mixed mixed JJ cord-022053-idft1p6d 337 24 infections infection NNS cord-022053-idft1p6d 337 25 than than IN cord-022053-idft1p6d 337 26 standard standard JJ cord-022053-idft1p6d 337 27 techniques technique NNS cord-022053-idft1p6d 337 28 . . . cord-022053-idft1p6d 338 1 104 104 CD cord-022053-idft1p6d 338 2 , , , cord-022053-idft1p6d 338 3 105 105 CD cord-022053-idft1p6d 338 4 For for IN cord-022053-idft1p6d 338 5 viral viral JJ cord-022053-idft1p6d 338 6 pathogens pathogen NNS cord-022053-idft1p6d 338 7 the the DT cord-022053-idft1p6d 338 8 FilmArray FilmArray NNP cord-022053-idft1p6d 338 9 GI GI NNP cord-022053-idft1p6d 338 10 panel panel NN cord-022053-idft1p6d 338 11 has have VBZ cord-022053-idft1p6d 338 12 shown show VBN cord-022053-idft1p6d 338 13 value value NN cord-022053-idft1p6d 338 14 in in IN cord-022053-idft1p6d 338 15 the the DT cord-022053-idft1p6d 338 16 younger young JJR cord-022053-idft1p6d 338 17 age age NN cord-022053-idft1p6d 338 18 groups group NNS cord-022053-idft1p6d 338 19 ( ( -LRB- cord-022053-idft1p6d 338 20 patients patient NNS cord-022053-idft1p6d 338 21 younger young JJR cord-022053-idft1p6d 338 22 than than IN cord-022053-idft1p6d 338 23 12 12 CD cord-022053-idft1p6d 338 24 years year NNS cord-022053-idft1p6d 338 25 ) ) -RRB- cord-022053-idft1p6d 338 26 for for IN cord-022053-idft1p6d 338 27 most most RBS cord-022053-idft1p6d 338 28 tested test VBN cord-022053-idft1p6d 338 29 pathogens pathogen NNS cord-022053-idft1p6d 338 30 ( ( -LRB- cord-022053-idft1p6d 338 31 sensitivity sensitivity NN cord-022053-idft1p6d 338 32 : : : cord-022053-idft1p6d 338 33 95.5 95.5 CD cord-022053-idft1p6d 338 34 % % NN cord-022053-idft1p6d 338 35 to to IN cord-022053-idft1p6d 338 36 100 100 CD cord-022053-idft1p6d 338 37 % % NN cord-022053-idft1p6d 338 38 ; ; , cord-022053-idft1p6d 338 39 specificity specificity NN cord-022053-idft1p6d 338 40 : : : cord-022053-idft1p6d 338 41 99.1 99.1 CD cord-022053-idft1p6d 338 42 % % NN cord-022053-idft1p6d 338 43 to to IN cord-022053-idft1p6d 338 44 99.9 99.9 CD cord-022053-idft1p6d 338 45 % % NN cord-022053-idft1p6d 338 46 ) ) -RRB- cord-022053-idft1p6d 338 47 , , , cord-022053-idft1p6d 338 48 whereas whereas IN cord-022053-idft1p6d 338 49 Norovirus Norovirus NNP cord-022053-idft1p6d 338 50 appears appear VBZ cord-022053-idft1p6d 338 51 to to TO cord-022053-idft1p6d 338 52 be be VB cord-022053-idft1p6d 338 53 valuable valuable JJ cord-022053-idft1p6d 338 54 across across IN cord-022053-idft1p6d 338 55 all all DT cord-022053-idft1p6d 338 56 age age NN cord-022053-idft1p6d 338 57 groups group NNS cord-022053-idft1p6d 338 58 ( ( -LRB- cord-022053-idft1p6d 338 59 sensitivity sensitivity NN cord-022053-idft1p6d 338 60 : : : cord-022053-idft1p6d 338 61 94.5 94.5 CD cord-022053-idft1p6d 338 62 % % NN cord-022053-idft1p6d 338 63 ; ; : cord-022053-idft1p6d 338 64 specificity specificity NN cord-022053-idft1p6d 338 65 : : : cord-022053-idft1p6d 338 66 98.8 98.8 CD cord-022053-idft1p6d 338 67 % % NN cord-022053-idft1p6d 338 68 ) ) -RRB- cord-022053-idft1p6d 338 69 . . . cord-022053-idft1p6d 339 1 103 103 CD cord-022053-idft1p6d 339 2 Performance performance NN cord-022053-idft1p6d 339 3 for for IN cord-022053-idft1p6d 339 4 parasitic parasitic JJ cord-022053-idft1p6d 339 5 pathogens pathogen NNS cord-022053-idft1p6d 339 6 in in IN cord-022053-idft1p6d 339 7 this this DT cord-022053-idft1p6d 339 8 panel panel NN cord-022053-idft1p6d 339 9 is be VBZ cord-022053-idft1p6d 339 10 equally equally RB cord-022053-idft1p6d 339 11 high high JJ cord-022053-idft1p6d 339 12 for for IN cord-022053-idft1p6d 339 13 Cryptosporidium cryptosporidium NN cord-022053-idft1p6d 339 14 , , , cord-022053-idft1p6d 339 15 Cyclospora Cyclospora NNP cord-022053-idft1p6d 339 16 , , , cord-022053-idft1p6d 339 17 and and CC cord-022053-idft1p6d 339 18 Giardia Giardia NNP cord-022053-idft1p6d 339 19 ( ( -LRB- cord-022053-idft1p6d 339 20 sensitivity sensitivity NN cord-022053-idft1p6d 339 21 : : : cord-022053-idft1p6d 339 22 100 100 CD cord-022053-idft1p6d 339 23 % % NN cord-022053-idft1p6d 339 24 ; ; , cord-022053-idft1p6d 339 25 specificity specificity NN cord-022053-idft1p6d 339 26 : : : cord-022053-idft1p6d 339 27 Vibrio vibrio NN cord-022053-idft1p6d 339 28 cholerae cholerae NN cord-022053-idft1p6d 339 29 , , , cord-022053-idft1p6d 339 30 and and CC cord-022053-idft1p6d 339 31 Y. Y. NNP cord-022053-idft1p6d 339 32 enterocolitica enterocolitica NNP cord-022053-idft1p6d 339 33 . . . cord-022053-idft1p6d 340 1 In in IN cord-022053-idft1p6d 340 2 one one CD cord-022053-idft1p6d 340 3 study study NN cord-022053-idft1p6d 340 4 comparing compare VBG cord-022053-idft1p6d 340 5 the the DT cord-022053-idft1p6d 340 6 xTAG xtag NN cord-022053-idft1p6d 340 7 with with IN cord-022053-idft1p6d 340 8 the the DT cord-022053-idft1p6d 340 9 FilmArray FilmArray NNP cord-022053-idft1p6d 340 10 and and CC cord-022053-idft1p6d 340 11 conventional conventional JJ cord-022053-idft1p6d 340 12 techniques technique NNS cord-022053-idft1p6d 340 13 , , , cord-022053-idft1p6d 340 14 the the DT cord-022053-idft1p6d 340 15 two two CD cord-022053-idft1p6d 340 16 platforms platform NNS cord-022053-idft1p6d 340 17 behaved behave VBD cord-022053-idft1p6d 340 18 comparably comparably RB cord-022053-idft1p6d 340 19 , , , cord-022053-idft1p6d 340 20 with with IN cord-022053-idft1p6d 340 21 the the DT cord-022053-idft1p6d 340 22 xTAG xtag NN cord-022053-idft1p6d 340 23 slightly slightly RB cord-022053-idft1p6d 340 24 trailing trail VBG cord-022053-idft1p6d 340 25 the the DT cord-022053-idft1p6d 340 26 FilmArray FilmArray NNP cord-022053-idft1p6d 340 27 in in IN cord-022053-idft1p6d 340 28 the the DT cord-022053-idft1p6d 340 29 diagnosis diagnosis NN cord-022053-idft1p6d 340 30 of of IN cord-022053-idft1p6d 340 31 mixed mixed JJ cord-022053-idft1p6d 340 32 infections infection NNS cord-022053-idft1p6d 340 33 ( ( -LRB- cord-022053-idft1p6d 340 34 27 27 CD cord-022053-idft1p6d 340 35 % % NN cord-022053-idft1p6d 340 36 for for IN cord-022053-idft1p6d 340 37 Fil Fil NNP cord-022053-idft1p6d 340 38 - - HYPH cord-022053-idft1p6d 340 39 mArray mArray NNP cord-022053-idft1p6d 340 40 vs vs IN cord-022053-idft1p6d 340 41 14.1 14.1 CD cord-022053-idft1p6d 340 42 % % NN cord-022053-idft1p6d 340 43 for for IN cord-022053-idft1p6d 340 44 xTAG xTAG NNP cord-022053-idft1p6d 340 45 vs vs IN cord-022053-idft1p6d 340 46 8.3 8.3 CD cord-022053-idft1p6d 340 47 % % NN cord-022053-idft1p6d 340 48 for for IN cord-022053-idft1p6d 340 49 routine routine JJ cord-022053-idft1p6d 340 50 testing testing NN cord-022053-idft1p6d 340 51 ) ) -RRB- cord-022053-idft1p6d 340 52 . . . cord-022053-idft1p6d 341 1 104 104 CD cord-022053-idft1p6d 342 1 The the DT cord-022053-idft1p6d 342 2 performance performance NN cord-022053-idft1p6d 342 3 of of IN cord-022053-idft1p6d 342 4 xTAG xTAG NNP cord-022053-idft1p6d 342 5 for for IN cord-022053-idft1p6d 342 6 viral viral JJ cord-022053-idft1p6d 342 7 pathogens pathogen NNS cord-022053-idft1p6d 342 8 when when WRB cord-022053-idft1p6d 342 9 compared compare VBN cord-022053-idft1p6d 342 10 with with IN cord-022053-idft1p6d 342 11 realtime realtime JJ cord-022053-idft1p6d 342 12 RT RT NNP cord-022053-idft1p6d 342 13 - - HYPH cord-022053-idft1p6d 342 14 PCR PCR NNP cord-022053-idft1p6d 342 15 and and CC cord-022053-idft1p6d 342 16 multiplex multiplex JJ cord-022053-idft1p6d 342 17 realtime realtime NN cord-022053-idft1p6d 342 18 RT RT NNP cord-022053-idft1p6d 342 19 - - HYPH cord-022053-idft1p6d 342 20 PCR PCR NNP cord-022053-idft1p6d 342 21 , , , cord-022053-idft1p6d 342 22 showed show VBD cord-022053-idft1p6d 342 23 a a DT cord-022053-idft1p6d 342 24 wide wide JJ cord-022053-idft1p6d 342 25 variation variation NN cord-022053-idft1p6d 342 26 in in IN cord-022053-idft1p6d 342 27 sensitivity sensitivity NN cord-022053-idft1p6d 342 28 across across IN cord-022053-idft1p6d 342 29 viruses virus NNS cord-022053-idft1p6d 342 30 for for IN cord-022053-idft1p6d 342 31 xTAG xtag JJ cord-022053-idft1p6d 342 32 ( ( -LRB- cord-022053-idft1p6d 342 33 20 20 CD cord-022053-idft1p6d 342 34 % % NN cord-022053-idft1p6d 342 35 to to TO cord-022053-idft1p6d 342 36 100 100 CD cord-022053-idft1p6d 342 37 % % NN cord-022053-idft1p6d 342 38 ) ) -RRB- cord-022053-idft1p6d 342 39 , , , cord-022053-idft1p6d 342 40 with with IN cord-022053-idft1p6d 342 41 performance performance NN cord-022053-idft1p6d 342 42 for for IN cord-022053-idft1p6d 342 43 RSV RSV NNP cord-022053-idft1p6d 342 44 - - HYPH cord-022053-idft1p6d 342 45 A A NNP cord-022053-idft1p6d 342 46 , , , cord-022053-idft1p6d 342 47 RSV RSV NNP cord-022053-idft1p6d 342 48 - - HYPH cord-022053-idft1p6d 342 49 B B NNP cord-022053-idft1p6d 342 50 , , , cord-022053-idft1p6d 342 51 H1N1 H1N1 NNP cord-022053-idft1p6d 342 52 , , , cord-022053-idft1p6d 342 53 and and CC cord-022053-idft1p6d 342 54 influenza influenza NN cord-022053-idft1p6d 342 55 B b NN cord-022053-idft1p6d 342 56 being be VBG cord-022053-idft1p6d 342 57 13.3 13.3 CD cord-022053-idft1p6d 342 58 % % NN cord-022053-idft1p6d 342 59 , , , cord-022053-idft1p6d 342 60 47.3 47.3 CD cord-022053-idft1p6d 342 61 % % NN cord-022053-idft1p6d 342 62 , , , cord-022053-idft1p6d 342 63 54.2 54.2 CD cord-022053-idft1p6d 342 64 % % NN cord-022053-idft1p6d 342 65 , , , cord-022053-idft1p6d 342 66 and and CC cord-022053-idft1p6d 342 67 20 20 CD cord-022053-idft1p6d 342 68 % % NN cord-022053-idft1p6d 342 69 , , , cord-022053-idft1p6d 342 70 respectively respectively RB cord-022053-idft1p6d 342 71 . . . cord-022053-idft1p6d 343 1 121 121 CD cord-022053-idft1p6d 344 1 In in IN cord-022053-idft1p6d 344 2 headto headto NN cord-022053-idft1p6d 344 3 - - HYPH cord-022053-idft1p6d 344 4 head head NN cord-022053-idft1p6d 344 5 comparisons comparison NNS cord-022053-idft1p6d 344 6 of of IN cord-022053-idft1p6d 344 7 FilmArray FilmArray NNP cord-022053-idft1p6d 344 8 , , , cord-022053-idft1p6d 344 9 eSensor eSensor NNP cord-022053-idft1p6d 344 10 RVP RVP NNP cord-022053-idft1p6d 344 11 , , , cord-022053-idft1p6d 344 12 and and CC cord-022053-idft1p6d 344 13 xTAG xTAG VBD cord-022053-idft1p6d 344 14 , , , cord-022053-idft1p6d 344 15 the the DT cord-022053-idft1p6d 344 16 three three CD cord-022053-idft1p6d 344 17 methods method NNS cord-022053-idft1p6d 344 18 were be VBD cord-022053-idft1p6d 344 19 essentially essentially RB cord-022053-idft1p6d 344 20 equivalent equivalent JJ cord-022053-idft1p6d 344 21 , , , cord-022053-idft1p6d 344 22 with with IN cord-022053-idft1p6d 344 23 xTAG xTAG VBN cord-022053-idft1p6d 344 24 having have VBG cord-022053-idft1p6d 344 25 the the DT cord-022053-idft1p6d 344 26 best good JJS cord-022053-idft1p6d 344 27 performance performance NN cord-022053-idft1p6d 344 28 for for IN cord-022053-idft1p6d 344 29 influenza influenza NN cord-022053-idft1p6d 344 30 A. a. NN cord-022053-idft1p6d 345 1 122 122 LS cord-022053-idft1p6d 345 2 Some some DT cord-022053-idft1p6d 345 3 of of IN cord-022053-idft1p6d 345 4 the the DT cord-022053-idft1p6d 345 5 caveats caveat NNS cord-022053-idft1p6d 345 6 of of IN cord-022053-idft1p6d 345 7 the the DT cord-022053-idft1p6d 345 8 xTAG xtag JJ cord-022053-idft1p6d 345 9 system system NN cord-022053-idft1p6d 345 10 are be VBP cord-022053-idft1p6d 345 11 addressed address VBN cord-022053-idft1p6d 345 12 with with IN cord-022053-idft1p6d 345 13 newer new JJR cord-022053-idft1p6d 345 14 Luminex Luminex NNP cord-022053-idft1p6d 345 15 platforms platform NNS cord-022053-idft1p6d 345 16 , , , cord-022053-idft1p6d 345 17 such such JJ cord-022053-idft1p6d 345 18 as as IN cord-022053-idft1p6d 345 19 the the DT cord-022053-idft1p6d 345 20 Aries Aries NNP cord-022053-idft1p6d 345 21 , , , cord-022053-idft1p6d 345 22 which which WDT cord-022053-idft1p6d 345 23 is be VBZ cord-022053-idft1p6d 345 24 a a DT cord-022053-idft1p6d 345 25 sampleto sampleto NN cord-022053-idft1p6d 345 26 - - HYPH cord-022053-idft1p6d 345 27 result result JJ cord-022053-idft1p6d 345 28 platform platform NN cord-022053-idft1p6d 345 29 for for IN cord-022053-idft1p6d 345 30 testing test VBG cord-022053-idft1p6d 345 31 primary primary JJ cord-022053-idft1p6d 345 32 clinical clinical JJ cord-022053-idft1p6d 345 33 specimens specimen NNS cord-022053-idft1p6d 345 34 . . . cord-022053-idft1p6d 346 1 The the DT cord-022053-idft1p6d 346 2 assay assay NN cord-022053-idft1p6d 346 3 consists consist VBZ cord-022053-idft1p6d 346 4 of of IN cord-022053-idft1p6d 346 5 real real JJ cord-022053-idft1p6d 346 6 - - HYPH cord-022053-idft1p6d 346 7 time time NN cord-022053-idft1p6d 346 8 PCR pcr NN cord-022053-idft1p6d 346 9 using use VBG cord-022053-idft1p6d 346 10 the the DT cord-022053-idft1p6d 346 11 Luminex Luminex NNP cord-022053-idft1p6d 346 12 MultiCode MultiCode NNP cord-022053-idft1p6d 346 13 technology technology NN cord-022053-idft1p6d 346 14 . . . cord-022053-idft1p6d 347 1 This this DT cord-022053-idft1p6d 347 2 system system NN cord-022053-idft1p6d 347 3 uses use VBZ cord-022053-idft1p6d 347 4 primers primer NNS cord-022053-idft1p6d 347 5 that that WDT cord-022053-idft1p6d 347 6 incorporate incorporate VBP cord-022053-idft1p6d 347 7 isobases isobase NNS cord-022053-idft1p6d 347 8 , , , cord-022053-idft1p6d 347 9 isoC isoc NN cord-022053-idft1p6d 347 10 and and CC cord-022053-idft1p6d 347 11 isoG isog PRP cord-022053-idft1p6d 347 12 , , , cord-022053-idft1p6d 347 13 which which WDT cord-022053-idft1p6d 347 14 , , , cord-022053-idft1p6d 347 15 when when WRB cord-022053-idft1p6d 347 16 incorporated incorporate VBN cord-022053-idft1p6d 347 17 , , , cord-022053-idft1p6d 347 18 can can MD cord-022053-idft1p6d 347 19 pair pair VB cord-022053-idft1p6d 347 20 only only RB cord-022053-idft1p6d 347 21 with with IN cord-022053-idft1p6d 347 22 each each DT cord-022053-idft1p6d 347 23 other other JJ cord-022053-idft1p6d 347 24 . . . cord-022053-idft1p6d 348 1 One one CD cord-022053-idft1p6d 348 2 isobase isobase NN cord-022053-idft1p6d 348 3 is be VBZ cord-022053-idft1p6d 348 4 tagged tag VBN cord-022053-idft1p6d 348 5 with with IN cord-022053-idft1p6d 348 6 a a DT cord-022053-idft1p6d 348 7 fluorescent fluorescent JJ cord-022053-idft1p6d 348 8 reporter reporter NN cord-022053-idft1p6d 348 9 , , , cord-022053-idft1p6d 348 10 and and CC cord-022053-idft1p6d 348 11 the the DT cord-022053-idft1p6d 348 12 other other JJ cord-022053-idft1p6d 348 13 is be VBZ cord-022053-idft1p6d 348 14 tagged tag VBN cord-022053-idft1p6d 348 15 with with IN cord-022053-idft1p6d 348 16 a a DT cord-022053-idft1p6d 348 17 quencher quencher NN cord-022053-idft1p6d 348 18 . . . cord-022053-idft1p6d 349 1 Upon upon IN cord-022053-idft1p6d 349 2 the the DT cord-022053-idft1p6d 349 3 successful successful JJ cord-022053-idft1p6d 349 4 generation generation NN cord-022053-idft1p6d 349 5 of of IN cord-022053-idft1p6d 349 6 product product NN cord-022053-idft1p6d 349 7 , , , cord-022053-idft1p6d 349 8 both both DT cord-022053-idft1p6d 349 9 isobases isobase NNS cord-022053-idft1p6d 349 10 are be VBP cord-022053-idft1p6d 349 11 incorporated incorporate VBN cord-022053-idft1p6d 349 12 and and CC cord-022053-idft1p6d 349 13 fluorescence fluorescence NN cord-022053-idft1p6d 349 14 decreases decrease NNS cord-022053-idft1p6d 349 15 . . . cord-022053-idft1p6d 350 1 A a DT cord-022053-idft1p6d 350 2 subsequent subsequent JJ cord-022053-idft1p6d 350 3 melt melt NN cord-022053-idft1p6d 350 4 curve curve NN cord-022053-idft1p6d 350 5 analysis analysis NN cord-022053-idft1p6d 350 6 is be VBZ cord-022053-idft1p6d 350 7 performed perform VBN cord-022053-idft1p6d 350 8 , , , cord-022053-idft1p6d 350 9 and and CC cord-022053-idft1p6d 350 10 fluorescence fluorescence NN cord-022053-idft1p6d 350 11 is be VBZ cord-022053-idft1p6d 350 12 restored restore VBN cord-022053-idft1p6d 350 13 . . . cord-022053-idft1p6d 351 1 Unlike unlike IN cord-022053-idft1p6d 351 2 the the DT cord-022053-idft1p6d 351 3 xTAG xtag JJ cord-022053-idft1p6d 351 4 technology technology NN cord-022053-idft1p6d 351 5 , , , cord-022053-idft1p6d 351 6 Multi Multi NNP cord-022053-idft1p6d 351 7 - - NNP cord-022053-idft1p6d 351 8 Code Code NNP cord-022053-idft1p6d 351 9 can can MD cord-022053-idft1p6d 351 10 be be VB cord-022053-idft1p6d 351 11 run run VBN cord-022053-idft1p6d 351 12 on on IN cord-022053-idft1p6d 351 13 either either CC cord-022053-idft1p6d 351 14 commercially commercially RB cord-022053-idft1p6d 351 15 available available JJ cord-022053-idft1p6d 351 16 real real JJ cord-022053-idft1p6d 351 17 - - HYPH cord-022053-idft1p6d 351 18 time time NN cord-022053-idft1p6d 351 19 PCR PCR NNP cord-022053-idft1p6d 351 20 systems system NNS cord-022053-idft1p6d 351 21 or or CC cord-022053-idft1p6d 351 22 within within IN cord-022053-idft1p6d 351 23 the the DT cord-022053-idft1p6d 351 24 sample sample NN cord-022053-idft1p6d 351 25 - - HYPH cord-022053-idft1p6d 351 26 to to IN cord-022053-idft1p6d 351 27 - - HYPH cord-022053-idft1p6d 351 28 result result NN cord-022053-idft1p6d 351 29 Aries Aries NNP cord-022053-idft1p6d 351 30 platform platform NN cord-022053-idft1p6d 351 31 from from IN cord-022053-idft1p6d 351 32 BD BD NNP cord-022053-idft1p6d 351 33 . . . cord-022053-idft1p6d 352 1 There there EX cord-022053-idft1p6d 352 2 is be VBZ cord-022053-idft1p6d 352 3 only only RB cord-022053-idft1p6d 352 4 one one CD cord-022053-idft1p6d 352 5 FDA FDA NNP cord-022053-idft1p6d 352 6 - - HYPH cord-022053-idft1p6d 352 7 approved approve VBN cord-022053-idft1p6d 352 8 test test NN cord-022053-idft1p6d 352 9 for for IN cord-022053-idft1p6d 352 10 this this DT cord-022053-idft1p6d 352 11 panel panel NN cord-022053-idft1p6d 352 12 , , , cord-022053-idft1p6d 352 13 an an DT cord-022053-idft1p6d 352 14 HSV-1 HSV-1 NNP cord-022053-idft1p6d 352 15 and and CC cord-022053-idft1p6d 352 16 HSV-2 HSV-2 NNP cord-022053-idft1p6d 352 17 panel panel NN cord-022053-idft1p6d 352 18 for for IN cord-022053-idft1p6d 352 19 use use NN cord-022053-idft1p6d 352 20 in in IN cord-022053-idft1p6d 352 21 testing testing NN cord-022053-idft1p6d 352 22 cutaneous cutaneous JJ cord-022053-idft1p6d 352 23 and and CC cord-022053-idft1p6d 352 24 mucocutaneous mucocutaneous JJ cord-022053-idft1p6d 352 25 lesions lesion NNS cord-022053-idft1p6d 352 26 . . . cord-022053-idft1p6d 353 1 Although although IN cord-022053-idft1p6d 353 2 all all DT cord-022053-idft1p6d 353 3 of of IN cord-022053-idft1p6d 353 4 the the DT cord-022053-idft1p6d 353 5 nucleic nucleic JJ cord-022053-idft1p6d 353 6 acid acid NN cord-022053-idft1p6d 353 7 - - HYPH cord-022053-idft1p6d 353 8 based base VBN cord-022053-idft1p6d 353 9 systems system NNS cord-022053-idft1p6d 353 10 described describe VBN cord-022053-idft1p6d 353 11 above above IN cord-022053-idft1p6d 353 12 demonstrate demonstrate VBP cord-022053-idft1p6d 353 13 high high JJ cord-022053-idft1p6d 353 14 levels level NNS cord-022053-idft1p6d 353 15 of of IN cord-022053-idft1p6d 353 16 sensitivity sensitivity NN cord-022053-idft1p6d 353 17 and and CC cord-022053-idft1p6d 353 18 specificity specificity NN cord-022053-idft1p6d 353 19 , , , cord-022053-idft1p6d 353 20 they -PRON- PRP cord-022053-idft1p6d 353 21 are be VBP cord-022053-idft1p6d 353 22 all all DT cord-022053-idft1p6d 353 23 inherently inherently RB cord-022053-idft1p6d 353 24 limited limited JJ cord-022053-idft1p6d 353 25 to to IN cord-022053-idft1p6d 353 26 a a DT cord-022053-idft1p6d 353 27 select select JJ cord-022053-idft1p6d 353 28 group group NN cord-022053-idft1p6d 353 29 of of IN cord-022053-idft1p6d 353 30 organisms organism NNS cord-022053-idft1p6d 353 31 based base VBN cord-022053-idft1p6d 353 32 on on IN cord-022053-idft1p6d 353 33 the the DT cord-022053-idft1p6d 353 34 probe probe NN cord-022053-idft1p6d 353 35 / / SYM cord-022053-idft1p6d 353 36 primer primer NN cord-022053-idft1p6d 353 37 sets set NNS cord-022053-idft1p6d 353 38 they -PRON- PRP cord-022053-idft1p6d 353 39 contain contain VBP cord-022053-idft1p6d 353 40 . . . cord-022053-idft1p6d 354 1 Open open JJ cord-022053-idft1p6d 354 2 assays assay NNS cord-022053-idft1p6d 354 3 using use VBG cord-022053-idft1p6d 354 4 broad broad JJ cord-022053-idft1p6d 354 5 - - HYPH cord-022053-idft1p6d 354 6 range range NN cord-022053-idft1p6d 354 7 primers primer NNS cord-022053-idft1p6d 355 1 that that DT cord-022053-idft1p6d 355 2 target target VBP cord-022053-idft1p6d 355 3 nearly nearly RB cord-022053-idft1p6d 355 4 universal universal JJ cord-022053-idft1p6d 355 5 sequences sequence NNS cord-022053-idft1p6d 355 6 are be VBP cord-022053-idft1p6d 355 7 nearly nearly RB cord-022053-idft1p6d 355 8 all all DT cord-022053-idft1p6d 355 9 based base VBN cord-022053-idft1p6d 355 10 on on IN cord-022053-idft1p6d 355 11 the the DT cord-022053-idft1p6d 355 12 1977 1977 CD cord-022053-idft1p6d 355 13 discovery discovery NN cord-022053-idft1p6d 355 14 by by IN cord-022053-idft1p6d 355 15 Carl Carl NNP cord-022053-idft1p6d 355 16 Woese Woese NNP cord-022053-idft1p6d 355 17 that that IN cord-022053-idft1p6d 355 18 the the DT cord-022053-idft1p6d 355 19 16S 16S NNP cord-022053-idft1p6d 355 20 rRNA rRNA NNP cord-022053-idft1p6d 355 21 subunit subunit NN cord-022053-idft1p6d 355 22 could could MD cord-022053-idft1p6d 355 23 be be VB cord-022053-idft1p6d 355 24 used use VBN cord-022053-idft1p6d 355 25 to to TO cord-022053-idft1p6d 355 26 determine determine VB cord-022053-idft1p6d 355 27 the the DT cord-022053-idft1p6d 355 28 phylogenetic phylogenetic JJ cord-022053-idft1p6d 355 29 structure structure NN cord-022053-idft1p6d 355 30 of of IN cord-022053-idft1p6d 355 31 the the DT cord-022053-idft1p6d 355 32 domains domain NNS cord-022053-idft1p6d 355 33 of of IN cord-022053-idft1p6d 355 34 life life NN cord-022053-idft1p6d 355 35 . . . cord-022053-idft1p6d 356 1 123 123 CD cord-022053-idft1p6d 357 1 Although although IN cord-022053-idft1p6d 357 2 this this DT cord-022053-idft1p6d 357 3 idea idea NN cord-022053-idft1p6d 357 4 represented represent VBD cord-022053-idft1p6d 357 5 a a DT cord-022053-idft1p6d 357 6 fundamental fundamental JJ cord-022053-idft1p6d 357 7 shift shift NN cord-022053-idft1p6d 357 8 in in IN cord-022053-idft1p6d 357 9 bacteriology bacteriology NN cord-022053-idft1p6d 357 10 , , , cord-022053-idft1p6d 357 11 it -PRON- PRP cord-022053-idft1p6d 357 12 took take VBD cord-022053-idft1p6d 357 13 many many JJ cord-022053-idft1p6d 357 14 years year NNS cord-022053-idft1p6d 357 15 for for IN cord-022053-idft1p6d 357 16 it -PRON- PRP cord-022053-idft1p6d 357 17 to to TO cord-022053-idft1p6d 357 18 be be VB cord-022053-idft1p6d 357 19 widely widely RB cord-022053-idft1p6d 357 20 accepted accept VBN cord-022053-idft1p6d 357 21 , , , cord-022053-idft1p6d 357 22 and and CC cord-022053-idft1p6d 357 23 even even RB cord-022053-idft1p6d 357 24 longer long RBR cord-022053-idft1p6d 357 25 for for IN cord-022053-idft1p6d 357 26 the the DT cord-022053-idft1p6d 357 27 use use NN cord-022053-idft1p6d 357 28 of of IN cord-022053-idft1p6d 357 29 16S 16S NNP cord-022053-idft1p6d 357 30 rRNA rrna NN cord-022053-idft1p6d 357 31 sequencing sequencing NN cord-022053-idft1p6d 357 32 ( ( -LRB- cord-022053-idft1p6d 357 33 16Sseq 16sseq CD cord-022053-idft1p6d 357 34 ) ) -RRB- cord-022053-idft1p6d 357 35 to to TO cord-022053-idft1p6d 357 36 be be VB cord-022053-idft1p6d 357 37 used use VBN cord-022053-idft1p6d 357 38 as as IN cord-022053-idft1p6d 357 39 a a DT cord-022053-idft1p6d 357 40 standard standard JJ cord-022053-idft1p6d 357 41 means mean VBZ cord-022053-idft1p6d 357 42 for for IN cord-022053-idft1p6d 357 43 identifying identify VBG cord-022053-idft1p6d 357 44 bacteria bacteria NNS cord-022053-idft1p6d 357 45 in in IN cord-022053-idft1p6d 357 46 the the DT cord-022053-idft1p6d 357 47 clinical clinical JJ cord-022053-idft1p6d 357 48 laboratory laboratory NN cord-022053-idft1p6d 357 49 . . . cord-022053-idft1p6d 358 1 124 124 CD cord-022053-idft1p6d 359 1 However however RB cord-022053-idft1p6d 359 2 , , , cord-022053-idft1p6d 359 3 since since IN cord-022053-idft1p6d 359 4 2000 2000 CD cord-022053-idft1p6d 359 5 , , , cord-022053-idft1p6d 359 6 16Sseq 16Sseq NNP cord-022053-idft1p6d 359 7 has have VBZ cord-022053-idft1p6d 359 8 become become VBN cord-022053-idft1p6d 359 9 the the DT cord-022053-idft1p6d 359 10 gold gold NN cord-022053-idft1p6d 359 11 standard standard NN cord-022053-idft1p6d 359 12 for for IN cord-022053-idft1p6d 359 13 determining determine VBG cord-022053-idft1p6d 359 14 bacterial bacterial JJ cord-022053-idft1p6d 359 15 species specie NNS cord-022053-idft1p6d 359 16 , , , cord-022053-idft1p6d 359 17 and and CC cord-022053-idft1p6d 359 18 its -PRON- PRP$ cord-022053-idft1p6d 359 19 analysis analysis NN cord-022053-idft1p6d 359 20 has have VBZ cord-022053-idft1p6d 359 21 led lead VBN cord-022053-idft1p6d 359 22 to to IN cord-022053-idft1p6d 359 23 a a DT cord-022053-idft1p6d 359 24 great great JJ cord-022053-idft1p6d 359 25 deal deal NN cord-022053-idft1p6d 359 26 of of IN cord-022053-idft1p6d 359 27 restructuring restructure VBG cord-022053-idft1p6d 359 28 and and CC cord-022053-idft1p6d 359 29 renaming rename VBG cord-022053-idft1p6d 359 30 among among IN cord-022053-idft1p6d 359 31 phyla phylum NNS cord-022053-idft1p6d 359 32 . . . cord-022053-idft1p6d 360 1 125 125 CD cord-022053-idft1p6d 361 1 Briefly briefly RB cord-022053-idft1p6d 361 2 , , , cord-022053-idft1p6d 361 3 the the DT cord-022053-idft1p6d 361 4 16S 16S NNP cord-022053-idft1p6d 361 5 gene gene NN cord-022053-idft1p6d 361 6 encodes encode VBZ cord-022053-idft1p6d 361 7 a a DT cord-022053-idft1p6d 361 8 portion portion NN cord-022053-idft1p6d 361 9 of of IN cord-022053-idft1p6d 361 10 the the DT cord-022053-idft1p6d 361 11 small small JJ cord-022053-idft1p6d 361 12 ribosomal ribosomal NN cord-022053-idft1p6d 361 13 ( ( -LRB- cord-022053-idft1p6d 361 14 30S 30S NNP cord-022053-idft1p6d 361 15 ) ) -RRB- cord-022053-idft1p6d 361 16 subunit subunit NN cord-022053-idft1p6d 361 17 and and CC cord-022053-idft1p6d 361 18 is be VBZ cord-022053-idft1p6d 361 19 composed compose VBN cord-022053-idft1p6d 361 20 of of IN cord-022053-idft1p6d 361 21 nine nine CD cord-022053-idft1p6d 361 22 variable variable JJ cord-022053-idft1p6d 361 23 regions region NNS cord-022053-idft1p6d 361 24 alternating alternate VBG cord-022053-idft1p6d 361 25 with with IN cord-022053-idft1p6d 361 26 nine nine CD cord-022053-idft1p6d 361 27 conserved conserve VBN cord-022053-idft1p6d 361 28 regions region NNS cord-022053-idft1p6d 361 29 ( ( -LRB- cord-022053-idft1p6d 361 30 Fig fig NN cord-022053-idft1p6d 361 31 . . . cord-022053-idft1p6d 361 32 6.2 6.2 CD cord-022053-idft1p6d 361 33 ) ) -RRB- cord-022053-idft1p6d 361 34 . . . cord-022053-idft1p6d 362 1 The the DT cord-022053-idft1p6d 362 2 gene gene NN cord-022053-idft1p6d 362 3 is be VBZ cord-022053-idft1p6d 362 4 sequenced sequence VBN cord-022053-idft1p6d 362 5 using use VBG cord-022053-idft1p6d 362 6 primers primer NNS cord-022053-idft1p6d 362 7 that that WDT cord-022053-idft1p6d 362 8 bind bind VBP cord-022053-idft1p6d 362 9 to to IN cord-022053-idft1p6d 362 10 the the DT cord-022053-idft1p6d 362 11 highly highly RB cord-022053-idft1p6d 362 12 conserved conserved JJ cord-022053-idft1p6d 362 13 regions region NNS cord-022053-idft1p6d 362 14 and and CC cord-022053-idft1p6d 362 15 then then RB cord-022053-idft1p6d 362 16 compared compare VBN cord-022053-idft1p6d 362 17 with with IN cord-022053-idft1p6d 362 18 a a DT cord-022053-idft1p6d 362 19 reference reference NN cord-022053-idft1p6d 362 20 database database NN cord-022053-idft1p6d 362 21 to to TO cord-022053-idft1p6d 362 22 identify identify VB cord-022053-idft1p6d 362 23 an an DT cord-022053-idft1p6d 362 24 isolate isolate NN cord-022053-idft1p6d 362 25 . . . cord-022053-idft1p6d 363 1 The the DT cord-022053-idft1p6d 363 2 choice choice NN cord-022053-idft1p6d 363 3 of of IN cord-022053-idft1p6d 363 4 database database NN cord-022053-idft1p6d 363 5 is be VBZ cord-022053-idft1p6d 363 6 typically typically RB cord-022053-idft1p6d 363 7 the the DT cord-022053-idft1p6d 363 8 most most RBS cord-022053-idft1p6d 363 9 challenging challenging JJ cord-022053-idft1p6d 363 10 part part NN cord-022053-idft1p6d 363 11 of of IN cord-022053-idft1p6d 363 12 the the DT cord-022053-idft1p6d 363 13 assay assay NN cord-022053-idft1p6d 363 14 . . . cord-022053-idft1p6d 364 1 There there EX cord-022053-idft1p6d 364 2 are be VBP cord-022053-idft1p6d 364 3 a a DT cord-022053-idft1p6d 364 4 number number NN cord-022053-idft1p6d 364 5 of of IN cord-022053-idft1p6d 364 6 databases database NNS cord-022053-idft1p6d 364 7 that that WDT cord-022053-idft1p6d 364 8 can can MD cord-022053-idft1p6d 364 9 be be VB cord-022053-idft1p6d 364 10 used use VBN cord-022053-idft1p6d 364 11 to to TO cord-022053-idft1p6d 364 12 identify identify VB cord-022053-idft1p6d 364 13 the the DT cord-022053-idft1p6d 364 14 sequence sequence NN cord-022053-idft1p6d 364 15 , , , cord-022053-idft1p6d 364 16 ranging range VBG cord-022053-idft1p6d 364 17 from from IN cord-022053-idft1p6d 364 18 large large JJ cord-022053-idft1p6d 364 19 , , , cord-022053-idft1p6d 364 20 public public JJ cord-022053-idft1p6d 364 21 , , , cord-022053-idft1p6d 364 22 uncurated uncurated JJ cord-022053-idft1p6d 364 23 or or CC cord-022053-idft1p6d 364 24 partially partially RB cord-022053-idft1p6d 364 25 curated curate VBN cord-022053-idft1p6d 364 26 databases database NNS cord-022053-idft1p6d 364 27 , , , cord-022053-idft1p6d 364 28 such such JJ cord-022053-idft1p6d 364 29 as as IN cord-022053-idft1p6d 364 30 Genbank Genbank NNP cord-022053-idft1p6d 364 31 and and CC cord-022053-idft1p6d 364 32 the the DT cord-022053-idft1p6d 364 33 Ribosome Ribosome NNP cord-022053-idft1p6d 364 34 Database Database NNP cord-022053-idft1p6d 364 35 Project Project NNP cord-022053-idft1p6d 364 36 ( ( -LRB- cord-022053-idft1p6d 364 37 RDP RDP NNP cord-022053-idft1p6d 364 38 , , , cord-022053-idft1p6d 364 39 University University NNP cord-022053-idft1p6d 364 40 of of IN cord-022053-idft1p6d 364 41 Michigan Michigan NNP cord-022053-idft1p6d 364 42 ) ) -RRB- cord-022053-idft1p6d 364 43 to to IN cord-022053-idft1p6d 364 44 commercial commercial JJ cord-022053-idft1p6d 364 45 , , , cord-022053-idft1p6d 364 46 highly highly RB cord-022053-idft1p6d 364 47 curated curate VBN cord-022053-idft1p6d 364 48 collections collection NNS cord-022053-idft1p6d 364 49 with with IN cord-022053-idft1p6d 364 50 a a DT cord-022053-idft1p6d 364 51 much much RB cord-022053-idft1p6d 364 52 more more RBR cord-022053-idft1p6d 364 53 limited limited JJ cord-022053-idft1p6d 364 54 scope scope NN cord-022053-idft1p6d 364 55 . . . cord-022053-idft1p6d 365 1 Identification identification NN cord-022053-idft1p6d 365 2 algorithms algorithm NNS cord-022053-idft1p6d 365 3 include include VBP cord-022053-idft1p6d 365 4 Ripseq Ripseq NNP cord-022053-idft1p6d 365 5 ( ( -LRB- cord-022053-idft1p6d 365 6 Pathogenomix Pathogenomix NNP cord-022053-idft1p6d 365 7 , , , cord-022053-idft1p6d 365 8 Santa Santa NNP cord-022053-idft1p6d 365 9 Cruz Cruz NNP cord-022053-idft1p6d 365 10 , , , cord-022053-idft1p6d 365 11 California California NNP cord-022053-idft1p6d 365 12 ) ) -RRB- cord-022053-idft1p6d 365 13 , , . cord-022053-idft1p6d 366 1 the the DT cord-022053-idft1p6d 366 2 Integrated Integrated NNP cord-022053-idft1p6d 366 3 Database Database NNP cord-022053-idft1p6d 366 4 Network Network NNP cord-022053-idft1p6d 366 5 System System NNP cord-022053-idft1p6d 366 6 has have VBZ cord-022053-idft1p6d 366 7 a a DT cord-022053-idft1p6d 366 8 TAT tat NN cord-022053-idft1p6d 366 9 of of IN cord-022053-idft1p6d 366 10 approximately approximately RB cord-022053-idft1p6d 366 11 2 2 CD cord-022053-idft1p6d 366 12 hours hour NNS cord-022053-idft1p6d 366 13 and and CC cord-022053-idft1p6d 366 14 has have VBZ cord-022053-idft1p6d 366 15 the the DT cord-022053-idft1p6d 366 16 advantage advantage NN cord-022053-idft1p6d 366 17 of of IN cord-022053-idft1p6d 366 18 offering offer VBG cord-022053-idft1p6d 366 19 flexible flexible JJ cord-022053-idft1p6d 366 20 pricing pricing NN cord-022053-idft1p6d 366 21 by by IN cord-022053-idft1p6d 366 22 which which WDT cord-022053-idft1p6d 366 23 the the DT cord-022053-idft1p6d 366 24 laboratory laboratory NN cord-022053-idft1p6d 366 25 is be VBZ cord-022053-idft1p6d 366 26 charged charge VBN cord-022053-idft1p6d 366 27 only only RB cord-022053-idft1p6d 366 28 for for IN cord-022053-idft1p6d 366 29 the the DT cord-022053-idft1p6d 366 30 tests test NNS cord-022053-idft1p6d 366 31 they -PRON- PRP cord-022053-idft1p6d 366 32 request request VBP cord-022053-idft1p6d 366 33 , , , cord-022053-idft1p6d 366 34 instead instead RB cord-022053-idft1p6d 366 35 of of IN cord-022053-idft1p6d 366 36 the the DT cord-022053-idft1p6d 366 37 entire entire JJ cord-022053-idft1p6d 366 38 panel panel NN cord-022053-idft1p6d 366 39 . . . cord-022053-idft1p6d 367 1 Disadvantages disadvantage NNS cord-022053-idft1p6d 367 2 include include VBP cord-022053-idft1p6d 367 3 the the DT cord-022053-idft1p6d 367 4 need need NN cord-022053-idft1p6d 367 5 to to TO cord-022053-idft1p6d 367 6 select select VB cord-022053-idft1p6d 367 7 the the DT cord-022053-idft1p6d 367 8 appropriate appropriate JJ cord-022053-idft1p6d 367 9 cartridge cartridge NN cord-022053-idft1p6d 367 10 based base VBN cord-022053-idft1p6d 367 11 on on IN cord-022053-idft1p6d 367 12 Gram Gram NNP cord-022053-idft1p6d 367 13 stain stain NN cord-022053-idft1p6d 367 14 results result NNS cord-022053-idft1p6d 367 15 for for IN cord-022053-idft1p6d 367 16 bloodstream bloodstream NN cord-022053-idft1p6d 367 17 diagnostics diagnostic NNS cord-022053-idft1p6d 367 18 . . . cord-022053-idft1p6d 368 1 Respiratory respiratory JJ cord-022053-idft1p6d 368 2 , , , cord-022053-idft1p6d 368 3 GI GI NNP cord-022053-idft1p6d 368 4 , , , cord-022053-idft1p6d 368 5 and and CC cord-022053-idft1p6d 368 6 bloodstream bloodstream NN cord-022053-idft1p6d 368 7 panels panel NNS cord-022053-idft1p6d 368 8 are be VBP cord-022053-idft1p6d 368 9 available available JJ cord-022053-idft1p6d 368 10 . . . cord-022053-idft1p6d 369 1 The the DT cord-022053-idft1p6d 369 2 Verigene Verigene NNP cord-022053-idft1p6d 369 3 platform platform NN cord-022053-idft1p6d 369 4 can can MD cord-022053-idft1p6d 369 5 detect detect VB cord-022053-idft1p6d 369 6 13 13 CD cord-022053-idft1p6d 369 7 respiratory respiratory JJ cord-022053-idft1p6d 369 8 viruses virus NNS cord-022053-idft1p6d 369 9 with with IN cord-022053-idft1p6d 369 10 high high JJ cord-022053-idft1p6d 369 11 sensitivity sensitivity NN cord-022053-idft1p6d 369 12 ( ( -LRB- cord-022053-idft1p6d 369 13 including include VBG cord-022053-idft1p6d 369 14 multiple multiple JJ cord-022053-idft1p6d 369 15 types type NNS cord-022053-idft1p6d 369 16 of of IN cord-022053-idft1p6d 369 17 influenza influenza NN cord-022053-idft1p6d 369 18 , , , cord-022053-idft1p6d 369 19 parainfluenza parainfluenza NNP cord-022053-idft1p6d 369 20 ) ) -RRB- cord-022053-idft1p6d 369 21 and and CC cord-022053-idft1p6d 369 22 three three CD cord-022053-idft1p6d 369 23 Bordetella Bordetella NNP cord-022053-idft1p6d 369 24 species specie NNS cord-022053-idft1p6d 369 25 ( ( -LRB- cord-022053-idft1p6d 369 26 B. B. NNP cord-022053-idft1p6d 369 27 pertussis pertussis NN cord-022053-idft1p6d 369 28 , , , cord-022053-idft1p6d 369 29 Bordetella Bordetella NNP cord-022053-idft1p6d 369 30 parapertussis/ parapertussis/ POS cord-022053-idft1p6d 369 31 Bordetella Bordetella NNP cord-022053-idft1p6d 369 32 bronchiseptica bronchiseptica NNP cord-022053-idft1p6d 369 33 , , , cord-022053-idft1p6d 369 34 and and CC cord-022053-idft1p6d 369 35 Bordetella Bordetella NNP cord-022053-idft1p6d 369 36 holmesii holmesii NNP cord-022053-idft1p6d 369 37 ) ) -RRB- cord-022053-idft1p6d 369 38 , , , cord-022053-idft1p6d 369 39 114 114 CD cord-022053-idft1p6d 369 40 , , , cord-022053-idft1p6d 369 41 115 115 CD cord-022053-idft1p6d 369 42 although although IN cord-022053-idft1p6d 369 43 one one CD cord-022053-idft1p6d 369 44 advantage advantage NN cord-022053-idft1p6d 369 45 of of IN cord-022053-idft1p6d 369 46 this this DT cord-022053-idft1p6d 369 47 system system NN cord-022053-idft1p6d 369 48 is be VBZ cord-022053-idft1p6d 369 49 the the DT cord-022053-idft1p6d 369 50 flexibility flexibility NN cord-022053-idft1p6d 369 51 to to TO cord-022053-idft1p6d 369 52 test test VB cord-022053-idft1p6d 369 53 limited limited JJ cord-022053-idft1p6d 369 54 panels panel NNS cord-022053-idft1p6d 369 55 based base VBN cord-022053-idft1p6d 369 56 on on IN cord-022053-idft1p6d 369 57 a a DT cord-022053-idft1p6d 369 58 given give VBN cord-022053-idft1p6d 369 59 population population NN cord-022053-idft1p6d 369 60 . . . cord-022053-idft1p6d 370 1 The the DT cord-022053-idft1p6d 370 2 GI GI NNP cord-022053-idft1p6d 370 3 panel panel NN cord-022053-idft1p6d 370 4 is be VBZ cord-022053-idft1p6d 370 5 somewhat somewhat RB cord-022053-idft1p6d 370 6 more more RBR cord-022053-idft1p6d 370 7 limited limited JJ cord-022053-idft1p6d 370 8 than than IN cord-022053-idft1p6d 370 9 the the DT cord-022053-idft1p6d 370 10 FilmArray FilmArray NNP cord-022053-idft1p6d 370 11 , , , cord-022053-idft1p6d 370 12 covering cover VBG cord-022053-idft1p6d 370 13 22 22 CD cord-022053-idft1p6d 370 14 targets target NNS cord-022053-idft1p6d 370 15 , , , cord-022053-idft1p6d 370 16 including include VBG cord-022053-idft1p6d 370 17 13 13 CD cord-022053-idft1p6d 370 18 bacteria bacteria NNS cord-022053-idft1p6d 370 19 , , , cord-022053-idft1p6d 370 20 5 5 CD cord-022053-idft1p6d 370 21 viruses virus NNS cord-022053-idft1p6d 370 22 , , , cord-022053-idft1p6d 370 23 and and CC cord-022053-idft1p6d 370 24 4 4 CD cord-022053-idft1p6d 370 25 parasites parasite NNS cord-022053-idft1p6d 370 26 . . . cord-022053-idft1p6d 371 1 Bacteria Bacteria NNS cord-022053-idft1p6d 371 2 include include VBP cord-022053-idft1p6d 371 3 the the DT cord-022053-idft1p6d 371 4 Campylobacter Campylobacter NNP cord-022053-idft1p6d 371 5 group group NN cord-022053-idft1p6d 371 6 , , , cord-022053-idft1p6d 371 7 Salmonella Salmonella NNP cord-022053-idft1p6d 371 8 spp spp NNS cord-022053-idft1p6d 371 9 . . . cord-022053-idft1p6d 372 1 , , , cord-022053-idft1p6d 372 2 Shigella Shigella NNP cord-022053-idft1p6d 372 3 spp spp NNS cord-022053-idft1p6d 372 4 . . . cord-022053-idft1p6d 373 1 , , , cord-022053-idft1p6d 373 2 Vibrio Vibrio NNP cord-022053-idft1p6d 373 3 group group NN cord-022053-idft1p6d 373 4 , , , cord-022053-idft1p6d 373 5 and and CC cord-022053-idft1p6d 373 6 Y. Y. NNP cord-022053-idft1p6d 373 7 enterocolitica enterocolitica NNP cord-022053-idft1p6d 373 8 , , , cord-022053-idft1p6d 373 9 as as RB cord-022053-idft1p6d 373 10 well well RB cord-022053-idft1p6d 373 11 as as IN cord-022053-idft1p6d 373 12 Shiga Shiga NNP cord-022053-idft1p6d 373 13 toxin toxin NN cord-022053-idft1p6d 373 14 . . . cord-022053-idft1p6d 374 1 In in IN cord-022053-idft1p6d 374 2 one one CD cord-022053-idft1p6d 374 3 study study NN cord-022053-idft1p6d 374 4 of of IN cord-022053-idft1p6d 374 5 725 725 CD cord-022053-idft1p6d 374 6 stool stool NN cord-022053-idft1p6d 374 7 samples sample NNS cord-022053-idft1p6d 374 8 the the DT cord-022053-idft1p6d 374 9 Verigene Verigene NNP cord-022053-idft1p6d 374 10 demonstrated demonstrate VBD cord-022053-idft1p6d 374 11 a a DT cord-022053-idft1p6d 374 12 98.5 98.5 CD cord-022053-idft1p6d 374 13 % % NN cord-022053-idft1p6d 374 14 agreement agreement NN cord-022053-idft1p6d 374 15 rate rate NN cord-022053-idft1p6d 374 16 with with IN cord-022053-idft1p6d 374 17 culture culture NN cord-022053-idft1p6d 374 18 . . . cord-022053-idft1p6d 375 1 116 116 CD cord-022053-idft1p6d 376 1 For for IN cord-022053-idft1p6d 376 2 the the DT cord-022053-idft1p6d 376 3 diagnosis diagnosis NN cord-022053-idft1p6d 376 4 of of IN cord-022053-idft1p6d 376 5 bloodstream bloodstream NN cord-022053-idft1p6d 376 6 infections infection NNS cord-022053-idft1p6d 376 7 , , , cord-022053-idft1p6d 376 8 the the DT cord-022053-idft1p6d 376 9 Verigene Verigene NNP cord-022053-idft1p6d 376 10 system system NN cord-022053-idft1p6d 376 11 has have VBZ cord-022053-idft1p6d 376 12 separate separate JJ cord-022053-idft1p6d 376 13 cartridges cartridge NNS cord-022053-idft1p6d 376 14 for for IN cord-022053-idft1p6d 376 15 gram gram NN cord-022053-idft1p6d 376 16 - - HYPH cord-022053-idft1p6d 376 17 positive positive JJ cord-022053-idft1p6d 376 18 and and CC cord-022053-idft1p6d 376 19 gram gram JJ cord-022053-idft1p6d 376 20 - - HYPH cord-022053-idft1p6d 376 21 negative negative JJ cord-022053-idft1p6d 376 22 organisms organism NNS cord-022053-idft1p6d 376 23 , , , cord-022053-idft1p6d 376 24 necessitating necessitate VBG cord-022053-idft1p6d 376 25 an an DT cord-022053-idft1p6d 376 26 accurate accurate JJ cord-022053-idft1p6d 376 27 Gram gram NN cord-022053-idft1p6d 376 28 stain stain NN cord-022053-idft1p6d 376 29 to to TO cord-022053-idft1p6d 376 30 pick pick VB cord-022053-idft1p6d 376 31 the the DT cord-022053-idft1p6d 376 32 appropriate appropriate JJ cord-022053-idft1p6d 376 33 test test NN cord-022053-idft1p6d 376 34 and and CC cord-022053-idft1p6d 376 35 making make VBG cord-022053-idft1p6d 376 36 polymicrobial polymicrobial JJ cord-022053-idft1p6d 376 37 testing test VBG cord-022053-idft1p6d 376 38 a a DT cord-022053-idft1p6d 376 39 bit bit NN cord-022053-idft1p6d 376 40 more more RBR cord-022053-idft1p6d 376 41 complicated complicated JJ cord-022053-idft1p6d 376 42 . . . cord-022053-idft1p6d 377 1 Each each DT cord-022053-idft1p6d 377 2 panel panel NN cord-022053-idft1p6d 377 3 assesses assess VBZ cord-022053-idft1p6d 377 4 a a DT cord-022053-idft1p6d 377 5 few few JJ cord-022053-idft1p6d 377 6 extra extra JJ cord-022053-idft1p6d 377 7 organisms organism NNS cord-022053-idft1p6d 377 8 than than IN cord-022053-idft1p6d 377 9 the the DT cord-022053-idft1p6d 377 10 FilmArray FilmArray NNP cord-022053-idft1p6d 377 11 single single JJ cord-022053-idft1p6d 377 12 panel panel NN cord-022053-idft1p6d 377 13 . . . cord-022053-idft1p6d 378 1 In in IN cord-022053-idft1p6d 378 2 addition addition NN cord-022053-idft1p6d 378 3 , , , cord-022053-idft1p6d 378 4 the the DT cord-022053-idft1p6d 378 5 gram gram NN cord-022053-idft1p6d 378 6 - - HYPH cord-022053-idft1p6d 378 7 negative negative JJ cord-022053-idft1p6d 378 8 panel panel NN cord-022053-idft1p6d 378 9 queries query VBZ cord-022053-idft1p6d 378 10 several several JJ cord-022053-idft1p6d 378 11 more more JJR cord-022053-idft1p6d 378 12 resistance resistance NN cord-022053-idft1p6d 378 13 targets target NNS cord-022053-idft1p6d 378 14 than than IN cord-022053-idft1p6d 378 15 the the DT cord-022053-idft1p6d 378 16 FilmArray FilmArray NNP cord-022053-idft1p6d 378 17 , , , cord-022053-idft1p6d 378 18 including include VBG cord-022053-idft1p6d 378 19 CTX CTX NNP cord-022053-idft1p6d 378 20 - - HYPH cord-022053-idft1p6d 378 21 M M NNP cord-022053-idft1p6d 378 22 , , , cord-022053-idft1p6d 378 23 IMP IMP NNP cord-022053-idft1p6d 378 24 , , , cord-022053-idft1p6d 378 25 NDM NDM NNP cord-022053-idft1p6d 378 26 , , , cord-022053-idft1p6d 378 27 OXA OXA NNP cord-022053-idft1p6d 378 28 , , , cord-022053-idft1p6d 378 29 and and CC cord-022053-idft1p6d 378 30 VIM vim NN cord-022053-idft1p6d 378 31 . . . cord-022053-idft1p6d 379 1 117 117 CD cord-022053-idft1p6d 379 2 Verigene Verigene NNP cord-022053-idft1p6d 379 3 in in IN cord-022053-idft1p6d 379 4 RPs rp NNS cord-022053-idft1p6d 379 5 has have VBZ cord-022053-idft1p6d 379 6 excellent excellent JJ cord-022053-idft1p6d 379 7 performance performance NN cord-022053-idft1p6d 379 8 for for IN cord-022053-idft1p6d 379 9 the the DT cord-022053-idft1p6d 379 10 influenza influenza NN cord-022053-idft1p6d 379 11 viruses virus NNS cord-022053-idft1p6d 379 12 ( ( -LRB- cord-022053-idft1p6d 379 13 A a NN cord-022053-idft1p6d 379 14 and and CC cord-022053-idft1p6d 379 15 B B NNP cord-022053-idft1p6d 379 16 ) ) -RRB- cord-022053-idft1p6d 379 17 , , , cord-022053-idft1p6d 379 18 including include VBG cord-022053-idft1p6d 379 19 the the DT cord-022053-idft1p6d 379 20 ability ability NN cord-022053-idft1p6d 379 21 to to TO cord-022053-idft1p6d 379 22 subtype subtype NN cord-022053-idft1p6d 379 23 viruses virus NNS cord-022053-idft1p6d 379 24 with with IN cord-022053-idft1p6d 379 25 perfect perfect JJ cord-022053-idft1p6d 379 26 agreement agreement NN cord-022053-idft1p6d 379 27 with with IN cord-022053-idft1p6d 379 28 gold gold JJ cord-022053-idft1p6d 379 29 standard standard JJ cord-022053-idft1p6d 379 30 methods method NNS cord-022053-idft1p6d 379 31 ( ( -LRB- cord-022053-idft1p6d 379 32 molecular molecular JJ cord-022053-idft1p6d 379 33 ) ) -RRB- cord-022053-idft1p6d 379 34 ; ; : cord-022053-idft1p6d 379 35 however however RB cord-022053-idft1p6d 379 36 , , , cord-022053-idft1p6d 379 37 mixed mixed JJ cord-022053-idft1p6d 379 38 infections infection NNS cord-022053-idft1p6d 379 39 with with IN cord-022053-idft1p6d 379 40 non non JJ cord-022053-idft1p6d 379 41 - - JJ cord-022053-idft1p6d 379 42 influenza influenza JJ cord-022053-idft1p6d 379 43 viruses virus NNS cord-022053-idft1p6d 379 44 dampen dampen VBP cord-022053-idft1p6d 379 45 performance performance NN cord-022053-idft1p6d 379 46 . . . cord-022053-idft1p6d 380 1 118 118 CD cord-022053-idft1p6d 380 2 Headto Headto NNP cord-022053-idft1p6d 380 3 - - HYPH cord-022053-idft1p6d 380 4 head head NN cord-022053-idft1p6d 380 5 comparisons comparison NNS cord-022053-idft1p6d 380 6 of of IN cord-022053-idft1p6d 380 7 the the DT cord-022053-idft1p6d 380 8 limited limited JJ cord-022053-idft1p6d 380 9 Verigene Verigene NNP cord-022053-idft1p6d 380 10 panel panel NN cord-022053-idft1p6d 380 11 ( ( -LRB- cord-022053-idft1p6d 380 12 influenza influenza NN cord-022053-idft1p6d 380 13 A a NN cord-022053-idft1p6d 380 14 and and CC cord-022053-idft1p6d 380 15 B b NN cord-022053-idft1p6d 380 16 , , , cord-022053-idft1p6d 380 17 RSV RSV NNP cord-022053-idft1p6d 380 18 ) ) -RRB- cord-022053-idft1p6d 380 19 with with IN cord-022053-idft1p6d 380 20 FilmArray FilmArray NNP cord-022053-idft1p6d 380 21 RP RP NNP cord-022053-idft1p6d 380 22 showed show VBD cord-022053-idft1p6d 380 23 equivalent equivalent JJ cord-022053-idft1p6d 380 24 detection detection NN cord-022053-idft1p6d 380 25 of of IN cord-022053-idft1p6d 380 26 the the DT cord-022053-idft1p6d 380 27 three three CD cord-022053-idft1p6d 380 28 major major JJ cord-022053-idft1p6d 380 29 pathogens pathogen NNS cord-022053-idft1p6d 380 30 at at IN cord-022053-idft1p6d 380 31 a a DT cord-022053-idft1p6d 380 32 slightly slightly RB cord-022053-idft1p6d 380 33 reduced reduce VBN cord-022053-idft1p6d 380 34 cost cost NN cord-022053-idft1p6d 380 35 for for IN cord-022053-idft1p6d 380 36 the the DT cord-022053-idft1p6d 380 37 Verigene Verigene NNP cord-022053-idft1p6d 380 38 ; ; : cord-022053-idft1p6d 380 39 thus thus RB cord-022053-idft1p6d 380 40 analysis analysis NN cord-022053-idft1p6d 380 41 of of IN cord-022053-idft1p6d 380 42 the the DT cord-022053-idft1p6d 380 43 clinical clinical JJ cord-022053-idft1p6d 380 44 population population NN cord-022053-idft1p6d 380 45 and and CC cord-022053-idft1p6d 380 46 the the DT cord-022053-idft1p6d 380 47 desires desire NNS cord-022053-idft1p6d 380 48 of of IN cord-022053-idft1p6d 380 49 the the DT cord-022053-idft1p6d 380 50 local local JJ cord-022053-idft1p6d 380 51 clinical clinical JJ cord-022053-idft1p6d 380 52 team team NN cord-022053-idft1p6d 380 53 for for IN cord-022053-idft1p6d 380 54 reported report VBN cord-022053-idft1p6d 380 55 virus virus NN cord-022053-idft1p6d 380 56 and and CC cord-022053-idft1p6d 380 57 actionable actionable JJ cord-022053-idft1p6d 380 58 diagnoses diagnosis NNS cord-022053-idft1p6d 380 59 may may MD cord-022053-idft1p6d 380 60 help help VB cord-022053-idft1p6d 380 61 in in IN cord-022053-idft1p6d 380 62 choosing choose VBG cord-022053-idft1p6d 380 63 between between IN cord-022053-idft1p6d 380 64 these these DT cord-022053-idft1p6d 380 65 technologies technology NNS cord-022053-idft1p6d 380 66 . . . cord-022053-idft1p6d 381 1 114 114 CD cord-022053-idft1p6d 381 2 xTAG xTAG VBD cord-022053-idft1p6d 381 3 The the DT cord-022053-idft1p6d 381 4 xTAG xtag JJ cord-022053-idft1p6d 381 5 assay assay NN cord-022053-idft1p6d 381 6 system system NN cord-022053-idft1p6d 381 7 from from IN cord-022053-idft1p6d 381 8 Luminex Luminex NNP cord-022053-idft1p6d 381 9 is be VBZ cord-022053-idft1p6d 381 10 a a DT cord-022053-idft1p6d 381 11 liquid liquid JJ cord-022053-idft1p6d 381 12 array array NN cord-022053-idft1p6d 381 13 based base VBN cord-022053-idft1p6d 381 14 on on IN cord-022053-idft1p6d 381 15 multiplex multiplex NN cord-022053-idft1p6d 381 16 PCR PCR NNP cord-022053-idft1p6d 381 17 followed follow VBN cord-022053-idft1p6d 381 18 by by IN cord-022053-idft1p6d 381 19 amplicon amplicon NN cord-022053-idft1p6d 381 20 extension extension NN cord-022053-idft1p6d 381 21 using use VBG cord-022053-idft1p6d 381 22 a a DT cord-022053-idft1p6d 381 23 targetspecific targetspecific NN cord-022053-idft1p6d 381 24 primer primer NN cord-022053-idft1p6d 381 25 . . . cord-022053-idft1p6d 382 1 The the DT cord-022053-idft1p6d 382 2 extension extension NN cord-022053-idft1p6d 382 3 step step NN cord-022053-idft1p6d 382 4 incorporates incorporate VBZ cord-022053-idft1p6d 382 5 a a DT cord-022053-idft1p6d 382 6 hybridization hybridization NN cord-022053-idft1p6d 382 7 tag tag NN cord-022053-idft1p6d 382 8 onto onto IN cord-022053-idft1p6d 382 9 the the DT cord-022053-idft1p6d 382 10 amplicon amplicon NN cord-022053-idft1p6d 382 11 , , , cord-022053-idft1p6d 382 12 along along IN cord-022053-idft1p6d 382 13 with with IN cord-022053-idft1p6d 382 14 a a DT cord-022053-idft1p6d 382 15 biotin biotin NN cord-022053-idft1p6d 382 16 label label NN cord-022053-idft1p6d 382 17 . . . cord-022053-idft1p6d 383 1 Elongated elongated JJ cord-022053-idft1p6d 383 2 , , , cord-022053-idft1p6d 383 3 tagged tagged NNP cord-022053-idft1p6d 383 4 amplicons amplicon NNS cord-022053-idft1p6d 383 5 are be VBP cord-022053-idft1p6d 383 6 then then RB cord-022053-idft1p6d 383 7 incubated incubate VBN cord-022053-idft1p6d 383 8 with with IN cord-022053-idft1p6d 383 9 polystyrene polystyrene NN cord-022053-idft1p6d 383 10 microbeads microbead NNS cord-022053-idft1p6d 383 11 of of IN cord-022053-idft1p6d 383 12 various various JJ cord-022053-idft1p6d 383 13 fluorescent fluorescent NN cord-022053-idft1p6d 383 14 profiles profile NNS cord-022053-idft1p6d 383 15 , , , cord-022053-idft1p6d 383 16 each each DT cord-022053-idft1p6d 383 17 coated coat VBN cord-022053-idft1p6d 383 18 with with IN cord-022053-idft1p6d 383 19 a a DT cord-022053-idft1p6d 383 20 specific specific JJ cord-022053-idft1p6d 383 21 anti anti JJ cord-022053-idft1p6d 383 22 - - JJ cord-022053-idft1p6d 383 23 tag tag JJ cord-022053-idft1p6d 383 24 sequence sequence NN cord-022053-idft1p6d 383 25 . . . cord-022053-idft1p6d 384 1 Bead bead NN cord-022053-idft1p6d 384 2 / / SYM cord-022053-idft1p6d 384 3 amplicon amplicon NN cord-022053-idft1p6d 384 4 pairs pair NNS cord-022053-idft1p6d 384 5 are be VBP cord-022053-idft1p6d 384 6 then then RB cord-022053-idft1p6d 384 7 stained stain VBN cord-022053-idft1p6d 384 8 with with IN cord-022053-idft1p6d 384 9 another another DT cord-022053-idft1p6d 384 10 streptavidin streptavidin NN cord-022053-idft1p6d 384 11 - - HYPH cord-022053-idft1p6d 384 12 linked link VBN cord-022053-idft1p6d 384 13 fluorophore fluorophore NN cord-022053-idft1p6d 384 14 . . . cord-022053-idft1p6d 385 1 The the DT cord-022053-idft1p6d 385 2 beads bead NNS cord-022053-idft1p6d 385 3 are be VBP cord-022053-idft1p6d 385 4 analyzed analyze VBN cord-022053-idft1p6d 385 5 by by IN cord-022053-idft1p6d 385 6 a a DT cord-022053-idft1p6d 385 7 system system NN cord-022053-idft1p6d 385 8 of of IN cord-022053-idft1p6d 385 9 two two CD cord-022053-idft1p6d 385 10 lasers laser NNS cord-022053-idft1p6d 385 11 on on IN cord-022053-idft1p6d 385 12 the the DT cord-022053-idft1p6d 385 13 xMAP xmap JJ cord-022053-idft1p6d 385 14 instrument instrument NN cord-022053-idft1p6d 385 15 . . . cord-022053-idft1p6d 386 1 The the DT cord-022053-idft1p6d 386 2 first first JJ cord-022053-idft1p6d 386 3 determines determine VBZ cord-022053-idft1p6d 386 4 which which WDT cord-022053-idft1p6d 386 5 beads bead NNS cord-022053-idft1p6d 386 6 are be VBP cord-022053-idft1p6d 386 7 bound bind VBN cord-022053-idft1p6d 386 8 to to IN cord-022053-idft1p6d 386 9 amplicons amplicon NNS cord-022053-idft1p6d 386 10 by by IN cord-022053-idft1p6d 386 11 way way NN cord-022053-idft1p6d 386 12 of of IN cord-022053-idft1p6d 386 13 the the DT cord-022053-idft1p6d 386 14 streptavidinfluorophore streptavidinfluorophore NN cord-022053-idft1p6d 386 15 . . . cord-022053-idft1p6d 387 1 The the DT cord-022053-idft1p6d 387 2 second second JJ cord-022053-idft1p6d 387 3 laser laser NN cord-022053-idft1p6d 387 4 indicates indicate VBZ cord-022053-idft1p6d 387 5 which which WDT cord-022053-idft1p6d 387 6 specific specific JJ cord-022053-idft1p6d 387 7 target target NN cord-022053-idft1p6d 387 8 was be VBD cord-022053-idft1p6d 387 9 amplified amplify VBN cord-022053-idft1p6d 387 10 by by IN cord-022053-idft1p6d 387 11 way way NN cord-022053-idft1p6d 387 12 of of IN cord-022053-idft1p6d 387 13 the the DT cord-022053-idft1p6d 387 14 unique unique JJ cord-022053-idft1p6d 387 15 fluorescence fluorescence NN cord-022053-idft1p6d 387 16 of of IN cord-022053-idft1p6d 387 17 that that DT cord-022053-idft1p6d 387 18 bound bind VBN cord-022053-idft1p6d 387 19 bead bead NN cord-022053-idft1p6d 387 20 . . . cord-022053-idft1p6d 388 1 119 119 CD cord-022053-idft1p6d 389 1 Although although IN cord-022053-idft1p6d 389 2 the the DT cord-022053-idft1p6d 389 3 Luminex Luminex NNP cord-022053-idft1p6d 389 4 platforms platform NNS cord-022053-idft1p6d 389 5 generally generally RB cord-022053-idft1p6d 389 6 have have VBP cord-022053-idft1p6d 389 7 the the DT cord-022053-idft1p6d 389 8 potential potential NN cord-022053-idft1p6d 389 9 to to TO cord-022053-idft1p6d 389 10 detect detect VB cord-022053-idft1p6d 389 11 the the DT cord-022053-idft1p6d 389 12 greatest great JJS cord-022053-idft1p6d 389 13 number number NN cord-022053-idft1p6d 389 14 of of IN cord-022053-idft1p6d 389 15 targets target NNS cord-022053-idft1p6d 389 16 , , , cord-022053-idft1p6d 389 17 drawbacks drawback NNS cord-022053-idft1p6d 389 18 include include VBP cord-022053-idft1p6d 389 19 the the DT cord-022053-idft1p6d 389 20 need need NN cord-022053-idft1p6d 389 21 for for IN cord-022053-idft1p6d 389 22 a a DT cord-022053-idft1p6d 389 23 separate separate JJ cord-022053-idft1p6d 389 24 nucleic nucleic JJ cord-022053-idft1p6d 389 25 acid acid NN cord-022053-idft1p6d 389 26 extraction extraction NN cord-022053-idft1p6d 389 27 step step NN cord-022053-idft1p6d 389 28 and and CC cord-022053-idft1p6d 389 29 longer long RBR cord-022053-idft1p6d 389 30 TAT tat NN cord-022053-idft1p6d 389 31 ( ( -LRB- cord-022053-idft1p6d 389 32 4 4 CD cord-022053-idft1p6d 389 33 hours hour NNS cord-022053-idft1p6d 389 34 or or CC cord-022053-idft1p6d 389 35 longer long RBR cord-022053-idft1p6d 389 36 ) ) -RRB- cord-022053-idft1p6d 390 1 then then RB cord-022053-idft1p6d 390 2 the the DT cord-022053-idft1p6d 390 3 other other JJ cord-022053-idft1p6d 390 4 multiplex multiplex JJ cord-022053-idft1p6d 390 5 platforms platform NNS cord-022053-idft1p6d 390 6 . . . cord-022053-idft1p6d 391 1 There there EX cord-022053-idft1p6d 391 2 are be VBP cord-022053-idft1p6d 391 3 two two CD cord-022053-idft1p6d 391 4 xTAG xtag JJ cord-022053-idft1p6d 391 5 platforms platform NNS cord-022053-idft1p6d 391 6 focused focus VBN cord-022053-idft1p6d 391 7 on on IN cord-022053-idft1p6d 391 8 respiratory respiratory JJ cord-022053-idft1p6d 391 9 testing testing NN cord-022053-idft1p6d 391 10 : : : cord-022053-idft1p6d 391 11 the the DT cord-022053-idft1p6d 391 12 original original JJ cord-022053-idft1p6d 391 13 xTAG xtag JJ cord-022053-idft1p6d 391 14 platform platform NN cord-022053-idft1p6d 391 15 , , , cord-022053-idft1p6d 391 16 restricted restrict VBN cord-022053-idft1p6d 391 17 to to IN cord-022053-idft1p6d 391 18 viral viral JJ cord-022053-idft1p6d 391 19 pathogens pathogen NNS cord-022053-idft1p6d 391 20 , , , cord-022053-idft1p6d 391 21 and and CC cord-022053-idft1p6d 391 22 the the DT cord-022053-idft1p6d 391 23 next next JJ cord-022053-idft1p6d 391 24 - - HYPH cord-022053-idft1p6d 391 25 generation generation NN cord-022053-idft1p6d 391 26 system system NN cord-022053-idft1p6d 391 27 ( ( -LRB- cord-022053-idft1p6d 391 28 NxTAG NxTAG NNP cord-022053-idft1p6d 391 29 ) ) -RRB- cord-022053-idft1p6d 391 30 , , , cord-022053-idft1p6d 391 31 which which WDT cord-022053-idft1p6d 391 32 included include VBD cord-022053-idft1p6d 391 33 several several JJ cord-022053-idft1p6d 391 34 bacterial bacterial JJ cord-022053-idft1p6d 391 35 pathogens pathogen NNS cord-022053-idft1p6d 391 36 as as RB cord-022053-idft1p6d 391 37 well well RB cord-022053-idft1p6d 391 38 , , , cord-022053-idft1p6d 391 39 including include VBG cord-022053-idft1p6d 391 40 Legionella Legionella NNP cord-022053-idft1p6d 391 41 pneumophila pneumophila NN cord-022053-idft1p6d 391 42 . . . cord-022053-idft1p6d 392 1 120 120 CD cord-022053-idft1p6d 393 1 The the DT cord-022053-idft1p6d 393 2 xTAG xtag JJ cord-022053-idft1p6d 393 3 Gastrointestinal Gastrointestinal NNP cord-022053-idft1p6d 393 4 Pathogens Pathogens NNPS cord-022053-idft1p6d 393 5 Panel Panel NNP cord-022053-idft1p6d 393 6 ( ( -LRB- cord-022053-idft1p6d 393 7 GPP GPP NNP cord-022053-idft1p6d 393 8 ) ) -RRB- cord-022053-idft1p6d 393 9 tests test NNS cord-022053-idft1p6d 393 10 for for IN cord-022053-idft1p6d 393 11 nine nine CD cord-022053-idft1p6d 393 12 bacterial bacterial JJ cord-022053-idft1p6d 393 13 , , , cord-022053-idft1p6d 393 14 three three CD cord-022053-idft1p6d 393 15 viral viral JJ cord-022053-idft1p6d 393 16 , , , cord-022053-idft1p6d 393 17 and and CC cord-022053-idft1p6d 393 18 three three CD cord-022053-idft1p6d 393 19 parasitic parasitic JJ cord-022053-idft1p6d 393 20 targets target NNS cord-022053-idft1p6d 393 21 . . . cord-022053-idft1p6d 394 1 Among among IN cord-022053-idft1p6d 394 2 bacterial bacterial JJ cord-022053-idft1p6d 394 3 loci locus NNS cord-022053-idft1p6d 394 4 , , , cord-022053-idft1p6d 394 5 the the DT cord-022053-idft1p6d 394 6 Luminex Luminex NNP cord-022053-idft1p6d 394 7 xTAG xtag NN cord-022053-idft1p6d 394 8 covers cover VBZ cord-022053-idft1p6d 395 1 Campylobacter Campylobacter NNP cord-022053-idft1p6d 395 2 , , , cord-022053-idft1p6d 395 3 C. C. NNP cord-022053-idft1p6d 395 4 difficile difficile NN cord-022053-idft1p6d 395 5 toxin toxin NN cord-022053-idft1p6d 395 6 A a NN cord-022053-idft1p6d 395 7 / / SYM cord-022053-idft1p6d 395 8 B B NNP cord-022053-idft1p6d 395 9 , , , cord-022053-idft1p6d 395 10 E. E. NNP cord-022053-idft1p6d 395 11 coli coli NNP cord-022053-idft1p6d 395 12 O157 O157 NNP cord-022053-idft1p6d 395 13 , , , cord-022053-idft1p6d 395 14 enterotoxigenic enterotoxigenic NNP cord-022053-idft1p6d 395 15 E. E. NNP cord-022053-idft1p6d 395 16 coli coli NNS cord-022053-idft1p6d 395 17 ( ( -LRB- cord-022053-idft1p6d 395 18 ETEC ETEC NNP cord-022053-idft1p6d 395 19 ) ) -RRB- cord-022053-idft1p6d 395 20 LT LT NNP cord-022053-idft1p6d 395 21 / / SYM cord-022053-idft1p6d 395 22 ST ST NNP cord-022053-idft1p6d 395 23 , , , cord-022053-idft1p6d 395 24 Shiga Shiga NNP cord-022053-idft1p6d 395 25 toxin toxin NN cord-022053-idft1p6d 395 26 - - HYPH cord-022053-idft1p6d 395 27 producing produce VBG cord-022053-idft1p6d 395 28 E. E. NNP cord-022053-idft1p6d 395 29 coli coli NNS cord-022053-idft1p6d 395 30 ( ( -LRB- cord-022053-idft1p6d 395 31 STEC STEC NNP cord-022053-idft1p6d 395 32 ) ) -RRB- cord-022053-idft1p6d 396 1 stx1 stx1 NNP cord-022053-idft1p6d 396 2 / / SYM cord-022053-idft1p6d 396 3 stx2 stx2 NNP cord-022053-idft1p6d 396 4 , , , cord-022053-idft1p6d 396 5 Salmonella Salmonella NNP cord-022053-idft1p6d 396 6 , , , cord-022053-idft1p6d 396 7 Shigella Shigella NNP cord-022053-idft1p6d 396 8 , , , cord-022053-idft1p6d 396 9 Sanger Sanger NNP cord-022053-idft1p6d 396 10 sequencing sequencing NN cord-022053-idft1p6d 396 11 , , , cord-022053-idft1p6d 396 12 which which WDT cord-022053-idft1p6d 396 13 is be VBZ cord-022053-idft1p6d 396 14 generally generally RB cord-022053-idft1p6d 396 15 unable unable JJ cord-022053-idft1p6d 396 16 to to TO cord-022053-idft1p6d 396 17 assess assess VB cord-022053-idft1p6d 396 18 polymicrobial polymicrobial JJ cord-022053-idft1p6d 396 19 infections infection NNS cord-022053-idft1p6d 396 20 , , , cord-022053-idft1p6d 396 21 although although IN cord-022053-idft1p6d 396 22 some some DT cord-022053-idft1p6d 396 23 analysis analysis NN cord-022053-idft1p6d 396 24 software software NN cord-022053-idft1p6d 396 25 packages package NNS cord-022053-idft1p6d 396 26 have have VBP cord-022053-idft1p6d 396 27 algorithms algorithm NNS cord-022053-idft1p6d 396 28 to to TO cord-022053-idft1p6d 396 29 deconvolute deconvolute VB cord-022053-idft1p6d 396 30 traces trace NNS cord-022053-idft1p6d 396 31 of of IN cord-022053-idft1p6d 396 32 16Sseq 16sseq CD cord-022053-idft1p6d 396 33 from from IN cord-022053-idft1p6d 396 34 two two CD cord-022053-idft1p6d 396 35 or or CC cord-022053-idft1p6d 396 36 three three CD cord-022053-idft1p6d 396 37 different different JJ cord-022053-idft1p6d 396 38 organisms organism NNS cord-022053-idft1p6d 396 39 . . . cord-022053-idft1p6d 397 1 148 148 CD cord-022053-idft1p6d 397 2 NGS NGS NNP cord-022053-idft1p6d 397 3 is be VBZ cord-022053-idft1p6d 397 4 a a DT cord-022053-idft1p6d 397 5 high high JJ cord-022053-idft1p6d 397 6 - - HYPH cord-022053-idft1p6d 397 7 throughput throughput NN cord-022053-idft1p6d 397 8 method method NN cord-022053-idft1p6d 397 9 that that WDT cord-022053-idft1p6d 397 10 generally generally RB cord-022053-idft1p6d 397 11 refers refer VBZ cord-022053-idft1p6d 397 12 to to IN cord-022053-idft1p6d 397 13 a a DT cord-022053-idft1p6d 397 14 massively massively RB cord-022053-idft1p6d 397 15 parallel parallel JJ cord-022053-idft1p6d 397 16 process process NN cord-022053-idft1p6d 397 17 that that WDT cord-022053-idft1p6d 397 18 generates generate VBZ cord-022053-idft1p6d 397 19 tremendous tremendous JJ cord-022053-idft1p6d 397 20 quantities quantity NNS cord-022053-idft1p6d 397 21 of of IN cord-022053-idft1p6d 397 22 raw raw JJ cord-022053-idft1p6d 397 23 sequence sequence NN cord-022053-idft1p6d 397 24 reads read VBZ cord-022053-idft1p6d 397 25 . . . cord-022053-idft1p6d 398 1 There there EX cord-022053-idft1p6d 398 2 are be VBP cord-022053-idft1p6d 398 3 a a DT cord-022053-idft1p6d 398 4 number number NN cord-022053-idft1p6d 398 5 of of IN cord-022053-idft1p6d 398 6 commercially commercially RB cord-022053-idft1p6d 398 7 available available JJ cord-022053-idft1p6d 398 8 platforms platform NNS cord-022053-idft1p6d 398 9 that that WDT cord-022053-idft1p6d 398 10 vary vary VBP cord-022053-idft1p6d 398 11 in in IN cord-022053-idft1p6d 398 12 the the DT cord-022053-idft1p6d 398 13 quantity quantity NN cord-022053-idft1p6d 398 14 , , , cord-022053-idft1p6d 398 15 quality quality NN cord-022053-idft1p6d 398 16 , , , cord-022053-idft1p6d 398 17 and and CC cord-022053-idft1p6d 398 18 length length NN cord-022053-idft1p6d 398 19 of of IN cord-022053-idft1p6d 398 20 the the DT cord-022053-idft1p6d 398 21 reads read NNS cord-022053-idft1p6d 398 22 that that IN cord-022053-idft1p6d 398 23 they -PRON- PRP cord-022053-idft1p6d 398 24 produce produce VBP cord-022053-idft1p6d 398 25 . . . cord-022053-idft1p6d 399 1 The the DT cord-022053-idft1p6d 399 2 majority majority NN cord-022053-idft1p6d 399 3 of of IN cord-022053-idft1p6d 399 4 these these DT cord-022053-idft1p6d 399 5 include include VBP cord-022053-idft1p6d 399 6 a a DT cord-022053-idft1p6d 399 7 step step NN cord-022053-idft1p6d 399 8 for for IN cord-022053-idft1p6d 399 9 clonal clonal JJ cord-022053-idft1p6d 399 10 amplification amplification NN cord-022053-idft1p6d 399 11 of of IN cord-022053-idft1p6d 399 12 the the DT cord-022053-idft1p6d 399 13 template template NN cord-022053-idft1p6d 399 14 and and CC cord-022053-idft1p6d 399 15 produce produce VBP cord-022053-idft1p6d 399 16 short short JJ cord-022053-idft1p6d 399 17 ( ( -LRB- cord-022053-idft1p6d 399 18 50 50 CD cord-022053-idft1p6d 399 19 to to TO cord-022053-idft1p6d 399 20 400 400 CD cord-022053-idft1p6d 399 21 bp bp NNS cord-022053-idft1p6d 399 22 ) ) -RRB- cord-022053-idft1p6d 399 23 reads read VBZ cord-022053-idft1p6d 399 24 . . . cord-022053-idft1p6d 400 1 For for IN cord-022053-idft1p6d 400 2 excellent excellent JJ cord-022053-idft1p6d 400 3 reviews review NNS cord-022053-idft1p6d 400 4 see see VBP cord-022053-idft1p6d 400 5 articles article NNS cord-022053-idft1p6d 400 6 provided provide VBN cord-022053-idft1p6d 400 7 in in IN cord-022053-idft1p6d 400 8 the the DT cord-022053-idft1p6d 400 9 reference reference NN cord-022053-idft1p6d 400 10 list list NN cord-022053-idft1p6d 400 11 . . . cord-022053-idft1p6d 401 1 149 149 CD cord-022053-idft1p6d 401 2 , , , cord-022053-idft1p6d 401 3 150 150 CD cord-022053-idft1p6d 402 1 The the DT cord-022053-idft1p6d 402 2 advent advent NN cord-022053-idft1p6d 402 3 of of IN cord-022053-idft1p6d 402 4 NGS NGS NNP cord-022053-idft1p6d 402 5 was be VBD cord-022053-idft1p6d 402 6 a a DT cord-022053-idft1p6d 402 7 groundbreaking groundbreaking JJ cord-022053-idft1p6d 402 8 event event NN cord-022053-idft1p6d 402 9 in in IN cord-022053-idft1p6d 402 10 clinical clinical JJ cord-022053-idft1p6d 402 11 medicine medicine NN cord-022053-idft1p6d 402 12 and and CC cord-022053-idft1p6d 402 13 is be VBZ cord-022053-idft1p6d 402 14 a a DT cord-022053-idft1p6d 402 15 key key JJ cord-022053-idft1p6d 402 16 component component NN cord-022053-idft1p6d 402 17 of of IN cord-022053-idft1p6d 402 18 initiatives initiative NNS cord-022053-idft1p6d 402 19 for for IN cord-022053-idft1p6d 402 20 " " `` cord-022053-idft1p6d 402 21 precision precision NN cord-022053-idft1p6d 402 22 medicine medicine NN cord-022053-idft1p6d 402 23 " " '' cord-022053-idft1p6d 402 24 for for IN cord-022053-idft1p6d 402 25 cancer cancer NN cord-022053-idft1p6d 402 26 . . . cord-022053-idft1p6d 403 1 Beyond beyond IN cord-022053-idft1p6d 403 2 human human JJ cord-022053-idft1p6d 403 3 genomic genomic JJ cord-022053-idft1p6d 403 4 analysis analysis NN cord-022053-idft1p6d 403 5 , , , cord-022053-idft1p6d 403 6 NGS NGS NNP cord-022053-idft1p6d 403 7 has have VBZ cord-022053-idft1p6d 403 8 also also RB cord-022053-idft1p6d 403 9 had have VBN cord-022053-idft1p6d 403 10 a a DT cord-022053-idft1p6d 403 11 tremendous tremendous JJ cord-022053-idft1p6d 403 12 influence influence NN cord-022053-idft1p6d 403 13 on on IN cord-022053-idft1p6d 403 14 clinical clinical JJ cord-022053-idft1p6d 403 15 microbiology microbiology NN cord-022053-idft1p6d 403 16 that that WDT cord-022053-idft1p6d 403 17 extends extend VBZ cord-022053-idft1p6d 403 18 from from IN cord-022053-idft1p6d 403 19 infectious infectious JJ cord-022053-idft1p6d 403 20 disease disease NN cord-022053-idft1p6d 403 21 testing testing NN cord-022053-idft1p6d 403 22 and and CC cord-022053-idft1p6d 403 23 epidemiology epidemiology NN cord-022053-idft1p6d 403 24 to to IN cord-022053-idft1p6d 403 25 analysis analysis NN cord-022053-idft1p6d 403 26 of of IN cord-022053-idft1p6d 403 27 the the DT cord-022053-idft1p6d 403 28 human human JJ cord-022053-idft1p6d 403 29 microbiome microbiome NN cord-022053-idft1p6d 403 30 in in IN cord-022053-idft1p6d 403 31 health health NN cord-022053-idft1p6d 403 32 , , , cord-022053-idft1p6d 403 33 disease disease NN cord-022053-idft1p6d 403 34 , , , cord-022053-idft1p6d 403 35 and and CC cord-022053-idft1p6d 403 36 intervention intervention NN cord-022053-idft1p6d 403 37 . . . cord-022053-idft1p6d 404 1 [ [ -LRB- cord-022053-idft1p6d 404 2 151 151 CD cord-022053-idft1p6d 404 3 ] ] -RRB- cord-022053-idft1p6d 404 4 [ [ -LRB- cord-022053-idft1p6d 404 5 152 152 CD cord-022053-idft1p6d 404 6 ] ] -RRB- cord-022053-idft1p6d 404 7 [ [ -LRB- cord-022053-idft1p6d 404 8 153 153 CD cord-022053-idft1p6d 404 9 ] ] -RRB- cord-022053-idft1p6d 405 1 Within within IN cord-022053-idft1p6d 405 2 the the DT cord-022053-idft1p6d 405 3 diagnostic diagnostic JJ cord-022053-idft1p6d 405 4 clinical clinical JJ cord-022053-idft1p6d 405 5 microbiology microbiology NN cord-022053-idft1p6d 405 6 laboratory laboratory NN cord-022053-idft1p6d 405 7 , , , cord-022053-idft1p6d 405 8 NGS NGS NNP cord-022053-idft1p6d 405 9 of of IN cord-022053-idft1p6d 405 10 microbial microbial JJ cord-022053-idft1p6d 405 11 whole whole JJ cord-022053-idft1p6d 405 12 genomes genome NNS cord-022053-idft1p6d 405 13 has have VBZ cord-022053-idft1p6d 405 14 been be VBN cord-022053-idft1p6d 405 15 applied apply VBN cord-022053-idft1p6d 405 16 as as IN cord-022053-idft1p6d 405 17 an an DT cord-022053-idft1p6d 405 18 alternative alternative NN cord-022053-idft1p6d 405 19 to to IN cord-022053-idft1p6d 405 20 traditional traditional JJ cord-022053-idft1p6d 405 21 methods method NNS cord-022053-idft1p6d 405 22 , , , cord-022053-idft1p6d 405 23 such such JJ cord-022053-idft1p6d 405 24 as as IN cord-022053-idft1p6d 405 25 pulsed pulse VBN cord-022053-idft1p6d 405 26 - - HYPH cord-022053-idft1p6d 405 27 field field NN cord-022053-idft1p6d 405 28 gel gel NN cord-022053-idft1p6d 405 29 electrophoresis electrophoresis NN cord-022053-idft1p6d 405 30 , , , cord-022053-idft1p6d 405 31 for for IN cord-022053-idft1p6d 405 32 clonality clonality NN cord-022053-idft1p6d 405 33 analysis analysis NN cord-022053-idft1p6d 405 34 in in IN cord-022053-idft1p6d 405 35 outbreak outbreak NN cord-022053-idft1p6d 405 36 tracking tracking NN cord-022053-idft1p6d 405 37 . . . cord-022053-idft1p6d 406 1 154 154 CD cord-022053-idft1p6d 407 1 The the DT cord-022053-idft1p6d 407 2 refinement refinement NN cord-022053-idft1p6d 407 3 made make VBD cord-022053-idft1p6d 407 4 possible possible JJ cord-022053-idft1p6d 407 5 with with IN cord-022053-idft1p6d 407 6 total total JJ cord-022053-idft1p6d 407 7 chromosomal chromosomal JJ cord-022053-idft1p6d 407 8 single single JJ cord-022053-idft1p6d 407 9 - - HYPH cord-022053-idft1p6d 407 10 nucleotide nucleotide NN cord-022053-idft1p6d 407 11 polymorphism polymorphism NN cord-022053-idft1p6d 407 12 analysis analysis NN cord-022053-idft1p6d 407 13 , , , cord-022053-idft1p6d 407 14 for for IN cord-022053-idft1p6d 407 15 example example NN cord-022053-idft1p6d 407 16 , , , cord-022053-idft1p6d 407 17 allowed allow VBD cord-022053-idft1p6d 407 18 one one CD cord-022053-idft1p6d 407 19 group group NN cord-022053-idft1p6d 407 20 to to TO cord-022053-idft1p6d 407 21 assess assess VB cord-022053-idft1p6d 407 22 the the DT cord-022053-idft1p6d 407 23 spread spread NN cord-022053-idft1p6d 407 24 of of IN cord-022053-idft1p6d 407 25 variants variant NNS cord-022053-idft1p6d 407 26 of of IN cord-022053-idft1p6d 407 27 a a DT cord-022053-idft1p6d 407 28 colonizing colonize VBG cord-022053-idft1p6d 407 29 population population NN cord-022053-idft1p6d 407 30 of of IN cord-022053-idft1p6d 407 31 carbapenem carbapenem NNP cord-022053-idft1p6d 407 32 - - HYPH cord-022053-idft1p6d 407 33 resistant resistant JJ cord-022053-idft1p6d 407 34 K. K. NNP cord-022053-idft1p6d 407 35 pneumoniae pneumoniae NN cord-022053-idft1p6d 407 36 from from IN cord-022053-idft1p6d 407 37 one one CD cord-022053-idft1p6d 407 38 patient patient NN cord-022053-idft1p6d 407 39 to to IN cord-022053-idft1p6d 407 40 several several JJ cord-022053-idft1p6d 407 41 others other NNS cord-022053-idft1p6d 407 42 in in IN cord-022053-idft1p6d 407 43 multiple multiple JJ cord-022053-idft1p6d 407 44 transmission transmission NN cord-022053-idft1p6d 407 45 events event NNS cord-022053-idft1p6d 407 46 . . . cord-022053-idft1p6d 408 1 These these DT cord-022053-idft1p6d 408 2 variants variant NNS cord-022053-idft1p6d 408 3 were be VBD cord-022053-idft1p6d 408 4 differentiated differentiate VBN cord-022053-idft1p6d 408 5 from from IN cord-022053-idft1p6d 408 6 each each DT cord-022053-idft1p6d 408 7 other other JJ cord-022053-idft1p6d 408 8 by by IN cord-022053-idft1p6d 408 9 fewer few JJR cord-022053-idft1p6d 408 10 than than IN cord-022053-idft1p6d 408 11 a a DT cord-022053-idft1p6d 408 12 dozen dozen NN cord-022053-idft1p6d 408 13 nucleotides nucleotide NNS cord-022053-idft1p6d 408 14 . . . cord-022053-idft1p6d 409 1 155 155 CD cord-022053-idft1p6d 410 1 Other other JJ cord-022053-idft1p6d 410 2 applications application NNS cord-022053-idft1p6d 410 3 that that WDT cord-022053-idft1p6d 410 4 are be VBP cord-022053-idft1p6d 410 5 becoming become VBG cord-022053-idft1p6d 410 6 more more RBR cord-022053-idft1p6d 410 7 and and CC cord-022053-idft1p6d 410 8 more more RBR cord-022053-idft1p6d 410 9 routine routine JJ cord-022053-idft1p6d 410 10 include include VBP cord-022053-idft1p6d 410 11 the the DT cord-022053-idft1p6d 410 12 characterization characterization NN cord-022053-idft1p6d 410 13 of of IN cord-022053-idft1p6d 410 14 unusual unusual JJ cord-022053-idft1p6d 410 15 pathogens pathogen NNS cord-022053-idft1p6d 410 16 , , , cord-022053-idft1p6d 410 17 the the DT cord-022053-idft1p6d 410 18 tracking tracking NN cord-022053-idft1p6d 410 19 of of IN cord-022053-idft1p6d 410 20 antibiotic antibiotic JJ cord-022053-idft1p6d 410 21 resistance resistance NN cord-022053-idft1p6d 410 22 genes gene NNS cord-022053-idft1p6d 410 23 , , , cord-022053-idft1p6d 410 24 and and CC cord-022053-idft1p6d 410 25 even even RB cord-022053-idft1p6d 410 26 the the DT cord-022053-idft1p6d 410 27 characterization characterization NN cord-022053-idft1p6d 410 28 of of IN cord-022053-idft1p6d 410 29 the the DT cord-022053-idft1p6d 410 30 plasmids plasmid NNS cord-022053-idft1p6d 410 31 that that WDT cord-022053-idft1p6d 410 32 carry carry VBP cord-022053-idft1p6d 410 33 them -PRON- PRP cord-022053-idft1p6d 410 34 through through IN cord-022053-idft1p6d 410 35 horizontal horizontal JJ cord-022053-idft1p6d 410 36 gene gene NN cord-022053-idft1p6d 410 37 transfer transfer NN cord-022053-idft1p6d 410 38 . . . cord-022053-idft1p6d 411 1 [ [ -LRB- cord-022053-idft1p6d 411 2 156 156 CD cord-022053-idft1p6d 411 3 ] ] -RRB- cord-022053-idft1p6d 411 4 [ [ -LRB- cord-022053-idft1p6d 411 5 157 157 CD cord-022053-idft1p6d 411 6 ] ] -RRB- cord-022053-idft1p6d 411 7 [ [ -LRB- cord-022053-idft1p6d 411 8 158 158 CD cord-022053-idft1p6d 411 9 ] ] -RRB- cord-022053-idft1p6d 411 10 [ [ -LRB- cord-022053-idft1p6d 411 11 159 159 CD cord-022053-idft1p6d 411 12 ] ] -RRB- cord-022053-idft1p6d 412 1 Although although IN cord-022053-idft1p6d 412 2 not not RB cord-022053-idft1p6d 412 3 yet yet RB cord-022053-idft1p6d 412 4 routine routine JJ cord-022053-idft1p6d 412 5 , , , cord-022053-idft1p6d 412 6 NGS NGS NNP cord-022053-idft1p6d 412 7 has have VBZ cord-022053-idft1p6d 412 8 been be VBN cord-022053-idft1p6d 412 9 used use VBN cord-022053-idft1p6d 412 10 to to TO cord-022053-idft1p6d 412 11 diagnose diagnose VB cord-022053-idft1p6d 412 12 infections infection NNS cord-022053-idft1p6d 412 13 directly directly RB cord-022053-idft1p6d 412 14 from from IN cord-022053-idft1p6d 412 15 primary primary JJ cord-022053-idft1p6d 412 16 samples sample NNS cord-022053-idft1p6d 412 17 in in IN cord-022053-idft1p6d 412 18 cases case NNS cord-022053-idft1p6d 412 19 in in IN cord-022053-idft1p6d 412 20 which which WDT cord-022053-idft1p6d 412 21 all all DT cord-022053-idft1p6d 412 22 conventional conventional JJ cord-022053-idft1p6d 412 23 techniques technique NNS cord-022053-idft1p6d 412 24 have have VBP cord-022053-idft1p6d 412 25 failed fail VBN cord-022053-idft1p6d 412 26 . . . cord-022053-idft1p6d 413 1 160 160 CD cord-022053-idft1p6d 414 1 In in IN cord-022053-idft1p6d 414 2 one one CD cord-022053-idft1p6d 414 3 report report NN cord-022053-idft1p6d 414 4 , , , cord-022053-idft1p6d 414 5 after after IN cord-022053-idft1p6d 414 6 4 4 CD cord-022053-idft1p6d 414 7 months month NNS cord-022053-idft1p6d 414 8 of of IN cord-022053-idft1p6d 414 9 progressive progressive JJ cord-022053-idft1p6d 414 10 neurologic neurologic JJ cord-022053-idft1p6d 414 11 symptoms symptom NNS cord-022053-idft1p6d 414 12 and and CC cord-022053-idft1p6d 414 13 a a DT cord-022053-idft1p6d 414 14 thorough thorough JJ cord-022053-idft1p6d 414 15 but but CC cord-022053-idft1p6d 414 16 unrevealing unrevealing JJ cord-022053-idft1p6d 414 17 infectious infectious JJ cord-022053-idft1p6d 414 18 disease disease NN cord-022053-idft1p6d 414 19 workup workup NN cord-022053-idft1p6d 414 20 , , , cord-022053-idft1p6d 414 21 NGS NGS NNP cord-022053-idft1p6d 414 22 was be VBD cord-022053-idft1p6d 414 23 finally finally RB cord-022053-idft1p6d 414 24 able able JJ cord-022053-idft1p6d 414 25 to to TO cord-022053-idft1p6d 414 26 diagnose diagnose VB cord-022053-idft1p6d 414 27 a a DT cord-022053-idft1p6d 414 28 case case NN cord-022053-idft1p6d 414 29 of of IN cord-022053-idft1p6d 414 30 neuroleptospirosis neuroleptospirosis NN cord-022053-idft1p6d 414 31 directly directly RB cord-022053-idft1p6d 414 32 from from IN cord-022053-idft1p6d 414 33 the the DT cord-022053-idft1p6d 414 34 CSF CSF NNP cord-022053-idft1p6d 414 35 of of IN cord-022053-idft1p6d 414 36 a a DT cord-022053-idft1p6d 414 37 14-year 14-year JJ cord-022053-idft1p6d 414 38 - - HYPH cord-022053-idft1p6d 414 39 old old JJ cord-022053-idft1p6d 414 40 boy boy NN cord-022053-idft1p6d 414 41 . . . cord-022053-idft1p6d 415 1 161 161 CD cord-022053-idft1p6d 416 1 In in IN cord-022053-idft1p6d 416 2 addition addition NN cord-022053-idft1p6d 416 3 to to IN cord-022053-idft1p6d 416 4 the the DT cord-022053-idft1p6d 416 5 detection detection NN cord-022053-idft1p6d 416 6 and and CC cord-022053-idft1p6d 416 7 characterization characterization NN cord-022053-idft1p6d 416 8 of of IN cord-022053-idft1p6d 416 9 pathogens pathogen NNS cord-022053-idft1p6d 416 10 , , , cord-022053-idft1p6d 416 11 NGS NGS NNP cord-022053-idft1p6d 416 12 has have VBZ cord-022053-idft1p6d 416 13 also also RB cord-022053-idft1p6d 416 14 proven prove VBN cord-022053-idft1p6d 416 15 to to TO cord-022053-idft1p6d 416 16 be be VB cord-022053-idft1p6d 416 17 an an DT cord-022053-idft1p6d 416 18 invaluable invaluable JJ cord-022053-idft1p6d 416 19 tool tool NN cord-022053-idft1p6d 416 20 for for IN cord-022053-idft1p6d 416 21 the the DT cord-022053-idft1p6d 416 22 characterization characterization NN cord-022053-idft1p6d 416 23 of of IN cord-022053-idft1p6d 416 24 the the DT cord-022053-idft1p6d 416 25 human human JJ cord-022053-idft1p6d 416 26 microbiome microbiome NN cord-022053-idft1p6d 416 27 . . . cord-022053-idft1p6d 417 1 The the DT cord-022053-idft1p6d 417 2 influence influence NN cord-022053-idft1p6d 417 3 of of IN cord-022053-idft1p6d 417 4 the the DT cord-022053-idft1p6d 417 5 microbiome microbiome NN cord-022053-idft1p6d 417 6 on on IN cord-022053-idft1p6d 417 7 human human JJ cord-022053-idft1p6d 417 8 health health NN cord-022053-idft1p6d 417 9 and and CC cord-022053-idft1p6d 417 10 disease disease NN cord-022053-idft1p6d 417 11 has have VBZ cord-022053-idft1p6d 417 12 become become VBN cord-022053-idft1p6d 417 13 progressively progressively RB cord-022053-idft1p6d 417 14 more more RBR cord-022053-idft1p6d 417 15 established established JJ cord-022053-idft1p6d 417 16 . . . cord-022053-idft1p6d 418 1 Examples example NNS cord-022053-idft1p6d 418 2 are be VBP cord-022053-idft1p6d 418 3 many many JJ cord-022053-idft1p6d 418 4 and and CC cord-022053-idft1p6d 418 5 include include VBP cord-022053-idft1p6d 418 6 the the DT cord-022053-idft1p6d 418 7 development development NN cord-022053-idft1p6d 418 8 of of IN cord-022053-idft1p6d 418 9 obesity obesity NN cord-022053-idft1p6d 418 10 , , , cord-022053-idft1p6d 418 11 the the DT cord-022053-idft1p6d 418 12 metabolism metabolism NN cord-022053-idft1p6d 418 13 of of IN cord-022053-idft1p6d 418 14 therapeutic therapeutic JJ cord-022053-idft1p6d 418 15 drugs drug NNS cord-022053-idft1p6d 418 16 , , , cord-022053-idft1p6d 418 17 and and CC cord-022053-idft1p6d 418 18 the the DT cord-022053-idft1p6d 418 19 development development NN cord-022053-idft1p6d 418 20 of of IN cord-022053-idft1p6d 418 21 inflammatory inflammatory JJ cord-022053-idft1p6d 418 22 bowel bowel NN cord-022053-idft1p6d 418 23 disease disease NN cord-022053-idft1p6d 418 24 . . . cord-022053-idft1p6d 419 1 [ [ -LRB- cord-022053-idft1p6d 419 2 162 162 CD cord-022053-idft1p6d 419 3 ] ] -RRB- cord-022053-idft1p6d 419 4 [ [ -LRB- cord-022053-idft1p6d 419 5 163 163 CD cord-022053-idft1p6d 419 6 ] ] -RRB- cord-022053-idft1p6d 419 7 [ [ -LRB- cord-022053-idft1p6d 419 8 164 164 CD cord-022053-idft1p6d 419 9 ] ] -RRB- cord-022053-idft1p6d 420 1 The the DT cord-022053-idft1p6d 420 2 two two CD cord-022053-idft1p6d 420 3 most most RBS cord-022053-idft1p6d 420 4 common common JJ cord-022053-idft1p6d 420 5 ways way NNS cord-022053-idft1p6d 420 6 of of IN cord-022053-idft1p6d 420 7 assessing assess VBG cord-022053-idft1p6d 420 8 the the DT cord-022053-idft1p6d 420 9 microbiome microbiome NN cord-022053-idft1p6d 420 10 are be VBP cord-022053-idft1p6d 420 11 by by IN cord-022053-idft1p6d 420 12 16S 16S NNP cord-022053-idft1p6d 420 13 rRNA rRNA NNP cord-022053-idft1p6d 420 14 or or CC cord-022053-idft1p6d 420 15 shotgun shotgun NN cord-022053-idft1p6d 420 16 metagenomics metagenomic NNS cord-022053-idft1p6d 420 17 . . . cord-022053-idft1p6d 421 1 NGS NGS NNP cord-022053-idft1p6d 421 2 16S 16S NNP cord-022053-idft1p6d 421 3 analysis analysis NN cord-022053-idft1p6d 421 4 entails entail VBZ cord-022053-idft1p6d 421 5 sequencing sequence VBG cord-022053-idft1p6d 421 6 one one CD cord-022053-idft1p6d 421 7 portion portion NN cord-022053-idft1p6d 421 8 of of IN cord-022053-idft1p6d 421 9 16S 16S NNP cord-022053-idft1p6d 421 10 rRNA rrna NN cord-022053-idft1p6d 421 11 from from IN cord-022053-idft1p6d 421 12 a a DT cord-022053-idft1p6d 421 13 mixed mixed JJ cord-022053-idft1p6d 421 14 community community NN cord-022053-idft1p6d 421 15 ( ( -LRB- cord-022053-idft1p6d 421 16 e.g. e.g. RB cord-022053-idft1p6d 421 17 , , , cord-022053-idft1p6d 421 18 stool stool VB cord-022053-idft1p6d 421 19 sample sample NN cord-022053-idft1p6d 421 20 ) ) -RRB- cord-022053-idft1p6d 421 21 with with IN cord-022053-idft1p6d 421 22 subsequent subsequent JJ cord-022053-idft1p6d 421 23 clustering clustering NN cord-022053-idft1p6d 421 24 of of IN cord-022053-idft1p6d 421 25 sequences sequence NNS cord-022053-idft1p6d 421 26 either either CC cord-022053-idft1p6d 421 27 against against IN cord-022053-idft1p6d 421 28 a a DT cord-022053-idft1p6d 421 29 reference reference NN cord-022053-idft1p6d 421 30 dataset dataset NN cord-022053-idft1p6d 421 31 or or CC cord-022053-idft1p6d 421 32 into into IN cord-022053-idft1p6d 421 33 operational operational JJ cord-022053-idft1p6d 421 34 taxonomic taxonomic JJ cord-022053-idft1p6d 421 35 units unit NNS cord-022053-idft1p6d 421 36 ( ( -LRB- cord-022053-idft1p6d 421 37 OTUs OTUs NNPS cord-022053-idft1p6d 421 38 ) ) -RRB- cord-022053-idft1p6d 421 39 . . . cord-022053-idft1p6d 422 1 It -PRON- PRP cord-022053-idft1p6d 422 2 gives give VBZ cord-022053-idft1p6d 422 3 a a DT cord-022053-idft1p6d 422 4 picture picture NN cord-022053-idft1p6d 422 5 of of IN cord-022053-idft1p6d 422 6 taxonomic taxonomic JJ cord-022053-idft1p6d 422 7 diversity diversity NN cord-022053-idft1p6d 422 8 in in IN cord-022053-idft1p6d 422 9 a a DT cord-022053-idft1p6d 422 10 sample sample NN cord-022053-idft1p6d 422 11 and and CC cord-022053-idft1p6d 422 12 allows allow VBZ cord-022053-idft1p6d 422 13 for for IN cord-022053-idft1p6d 422 14 the the DT cord-022053-idft1p6d 422 15 analysis analysis NN cord-022053-idft1p6d 422 16 of of IN cord-022053-idft1p6d 422 17 changing change VBG cord-022053-idft1p6d 422 18 taxonomic taxonomic JJ cord-022053-idft1p6d 422 19 composition composition NN cord-022053-idft1p6d 422 20 in in IN cord-022053-idft1p6d 422 21 the the DT cord-022053-idft1p6d 422 22 face face NN cord-022053-idft1p6d 422 23 of of IN cord-022053-idft1p6d 422 24 various various JJ cord-022053-idft1p6d 422 25 perturbations perturbation NNS cord-022053-idft1p6d 422 26 and and CC cord-022053-idft1p6d 422 27 interventions intervention NNS cord-022053-idft1p6d 422 28 , , , cord-022053-idft1p6d 422 29 such such JJ cord-022053-idft1p6d 422 30 as as IN cord-022053-idft1p6d 422 31 antibiotic antibiotic JJ cord-022053-idft1p6d 422 32 administration administration NN cord-022053-idft1p6d 422 33 . . . cord-022053-idft1p6d 423 1 Shotgun shotgun NN cord-022053-idft1p6d 423 2 metagenomics metagenomic NNS cord-022053-idft1p6d 423 3 refers refer VBZ cord-022053-idft1p6d 423 4 to to IN cord-022053-idft1p6d 423 5 the the DT cord-022053-idft1p6d 423 6 sequencing sequencing NN cord-022053-idft1p6d 423 7 of of IN cord-022053-idft1p6d 423 8 total total JJ cord-022053-idft1p6d 423 9 DNA dna NN cord-022053-idft1p6d 423 10 from from IN cord-022053-idft1p6d 423 11 a a DT cord-022053-idft1p6d 423 12 mixed mixed JJ cord-022053-idft1p6d 423 13 community community NN cord-022053-idft1p6d 423 14 . . . cord-022053-idft1p6d 424 1 This this DT cord-022053-idft1p6d 424 2 technique technique NN cord-022053-idft1p6d 424 3 allows allow VBZ cord-022053-idft1p6d 424 4 for for IN cord-022053-idft1p6d 424 5 more more RBR cord-022053-idft1p6d 424 6 refined refined JJ cord-022053-idft1p6d 424 7 organism organism NN cord-022053-idft1p6d 424 8 identification identification NN cord-022053-idft1p6d 424 9 and and CC cord-022053-idft1p6d 424 10 an an DT cord-022053-idft1p6d 424 11 analysis analysis NN cord-022053-idft1p6d 424 12 of of IN cord-022053-idft1p6d 424 13 biochemical biochemical JJ cord-022053-idft1p6d 424 14 pathways pathway NNS cord-022053-idft1p6d 424 15 , , , cord-022053-idft1p6d 424 16 resistance resistance NN cord-022053-idft1p6d 424 17 genes gene NNS cord-022053-idft1p6d 424 18 , , , cord-022053-idft1p6d 424 19 etc etc FW cord-022053-idft1p6d 424 20 . . . cord-022053-idft1p6d 425 1 but but CC cord-022053-idft1p6d 425 2 requires require VBZ cord-022053-idft1p6d 425 3 a a DT cord-022053-idft1p6d 425 4 greater great JJR cord-022053-idft1p6d 425 5 amount amount NN cord-022053-idft1p6d 425 6 of of IN cord-022053-idft1p6d 425 7 raw raw JJ cord-022053-idft1p6d 425 8 sequence sequence NN cord-022053-idft1p6d 425 9 . . . cord-022053-idft1p6d 426 1 165 165 CD cord-022053-idft1p6d 426 2 , , , cord-022053-idft1p6d 426 3 166 166 CD cord-022053-idft1p6d 426 4 ( ( -LRB- cord-022053-idft1p6d 426 5 IDNS IDNS NNP cord-022053-idft1p6d 426 6 ) ) -RRB- cord-022053-idft1p6d 426 7 ( ( -LRB- cord-022053-idft1p6d 426 8 SmartGene SmartGene NNP cord-022053-idft1p6d 426 9 , , , cord-022053-idft1p6d 426 10 Raleigh Raleigh NNP cord-022053-idft1p6d 426 11 , , , cord-022053-idft1p6d 426 12 North North NNP cord-022053-idft1p6d 426 13 Carolina Carolina NNP cord-022053-idft1p6d 426 14 ) ) -RRB- cord-022053-idft1p6d 426 15 , , , cord-022053-idft1p6d 426 16 and and CC cord-022053-idft1p6d 426 17 MicroSEQ microseq NN cord-022053-idft1p6d 426 18 ( ( -LRB- cord-022053-idft1p6d 426 19 Applied Applied NNP cord-022053-idft1p6d 426 20 Biosystems Biosystems NNP cord-022053-idft1p6d 426 21 , , , cord-022053-idft1p6d 426 22 Thermo Thermo NNP cord-022053-idft1p6d 426 23 - - HYPH cord-022053-idft1p6d 426 24 Fisher Fisher NNP cord-022053-idft1p6d 426 25 , , , cord-022053-idft1p6d 426 26 Waltham Waltham NNP cord-022053-idft1p6d 426 27 , , , cord-022053-idft1p6d 426 28 Massachusetts Massachusetts NNP cord-022053-idft1p6d 426 29 ) ) -RRB- cord-022053-idft1p6d 426 30 . . . cord-022053-idft1p6d 427 1 The the DT cord-022053-idft1p6d 427 2 first first JJ cord-022053-idft1p6d 427 3 two two CD cord-022053-idft1p6d 427 4 products product NNS cord-022053-idft1p6d 427 5 are be VBP cord-022053-idft1p6d 427 6 solely solely RB cord-022053-idft1p6d 427 7 bioinformatic bioinformatic JJ cord-022053-idft1p6d 427 8 reference reference NN cord-022053-idft1p6d 427 9 solutions solution NNS cord-022053-idft1p6d 427 10 . . . cord-022053-idft1p6d 428 1 The the DT cord-022053-idft1p6d 428 2 last last JJ cord-022053-idft1p6d 428 3 includes include VBZ cord-022053-idft1p6d 428 4 both both DT cord-022053-idft1p6d 428 5 reagents reagent NNS cord-022053-idft1p6d 428 6 and and CC cord-022053-idft1p6d 428 7 access access NN cord-022053-idft1p6d 428 8 to to IN cord-022053-idft1p6d 428 9 a a DT cord-022053-idft1p6d 428 10 curated curate VBN cord-022053-idft1p6d 428 11 database database NN cord-022053-idft1p6d 428 12 . . . cord-022053-idft1p6d 429 1 None none NN cord-022053-idft1p6d 429 2 of of IN cord-022053-idft1p6d 429 3 these these DT cord-022053-idft1p6d 429 4 products product NNS cord-022053-idft1p6d 429 5 are be VBP cord-022053-idft1p6d 429 6 FDA FDA NNP cord-022053-idft1p6d 429 7 approved approve VBN cord-022053-idft1p6d 429 8 . . . cord-022053-idft1p6d 430 1 The the DT cord-022053-idft1p6d 430 2 Clinical Clinical NNP cord-022053-idft1p6d 430 3 and and CC cord-022053-idft1p6d 430 4 Laboratory Laboratory NNP cord-022053-idft1p6d 430 5 Standards Standards NNPS cord-022053-idft1p6d 430 6 Institute Institute NNP cord-022053-idft1p6d 430 7 ( ( -LRB- cord-022053-idft1p6d 430 8 CLSI CLSI NNP cord-022053-idft1p6d 430 9 ) ) -RRB- cord-022053-idft1p6d 430 10 has have VBZ cord-022053-idft1p6d 430 11 published publish VBN cord-022053-idft1p6d 430 12 guidelines guideline NNS cord-022053-idft1p6d 430 13 for for IN cord-022053-idft1p6d 430 14 the the DT cord-022053-idft1p6d 430 15 identification identification NN cord-022053-idft1p6d 430 16 of of IN cord-022053-idft1p6d 430 17 organisms organism NNS cord-022053-idft1p6d 430 18 by by IN cord-022053-idft1p6d 430 19 nucleic nucleic JJ cord-022053-idft1p6d 430 20 acid acid NN cord-022053-idft1p6d 430 21 sequencing sequencing NN cord-022053-idft1p6d 430 22 in in IN cord-022053-idft1p6d 430 23 which which WDT cord-022053-idft1p6d 430 24 the the DT cord-022053-idft1p6d 430 25 recommended recommend VBN cord-022053-idft1p6d 430 26 percentage percentage NN cord-022053-idft1p6d 430 27 identity identity NN cord-022053-idft1p6d 430 28 to to TO cord-022053-idft1p6d 430 29 make make VB cord-022053-idft1p6d 430 30 a a DT cord-022053-idft1p6d 430 31 match match NN cord-022053-idft1p6d 430 32 and and CC cord-022053-idft1p6d 430 33 guidance guidance NN cord-022053-idft1p6d 430 34 for for IN cord-022053-idft1p6d 430 35 organisms organism NNS cord-022053-idft1p6d 430 36 requiring require VBG cord-022053-idft1p6d 430 37 additional additional JJ cord-022053-idft1p6d 430 38 targets target NNS cord-022053-idft1p6d 430 39 ( ( -LRB- cord-022053-idft1p6d 430 40 e.g. e.g. RB cord-022053-idft1p6d 430 41 , , , cord-022053-idft1p6d 430 42 rpoB rpoB '' cord-022053-idft1p6d 430 43 , , , cord-022053-idft1p6d 430 44 hsp65 hsp65 ADD cord-022053-idft1p6d 430 45 ) ) -RRB- cord-022053-idft1p6d 430 46 for for IN cord-022053-idft1p6d 430 47 accurate accurate JJ cord-022053-idft1p6d 430 48 speciation speciation NN cord-022053-idft1p6d 430 49 are be VBP cord-022053-idft1p6d 430 50 laid lay VBN cord-022053-idft1p6d 430 51 forth forth RB cord-022053-idft1p6d 430 52 . . . cord-022053-idft1p6d 431 1 126 126 CD cord-022053-idft1p6d 432 1 The the DT cord-022053-idft1p6d 432 2 use use NN cord-022053-idft1p6d 432 3 of of IN cord-022053-idft1p6d 432 4 16Sseq 16sseq CD cord-022053-idft1p6d 432 5 in in IN cord-022053-idft1p6d 432 6 the the DT cord-022053-idft1p6d 432 7 clinical clinical JJ cord-022053-idft1p6d 432 8 microbiology microbiology NN cord-022053-idft1p6d 432 9 laboratory laboratory NN cord-022053-idft1p6d 432 10 has have VBZ cord-022053-idft1p6d 432 11 been be VBN cord-022053-idft1p6d 432 12 shown show VBN cord-022053-idft1p6d 432 13 to to TO cord-022053-idft1p6d 432 14 be be VB cord-022053-idft1p6d 432 15 particularly particularly RB cord-022053-idft1p6d 432 16 useful useful JJ cord-022053-idft1p6d 432 17 in in IN cord-022053-idft1p6d 432 18 such such JJ cord-022053-idft1p6d 432 19 applications application NNS cord-022053-idft1p6d 432 20 as as IN cord-022053-idft1p6d 432 21 the the DT cord-022053-idft1p6d 432 22 identification identification NN cord-022053-idft1p6d 432 23 of of IN cord-022053-idft1p6d 432 24 unusual unusual JJ cord-022053-idft1p6d 432 25 and/or and/or CC cord-022053-idft1p6d 432 26 slow slow RB cord-022053-idft1p6d 432 27 - - HYPH cord-022053-idft1p6d 432 28 growing grow VBG cord-022053-idft1p6d 432 29 organisms organism NNS cord-022053-idft1p6d 432 30 and and CC cord-022053-idft1p6d 432 31 the the DT cord-022053-idft1p6d 432 32 identification identification NN cord-022053-idft1p6d 432 33 of of IN cord-022053-idft1p6d 432 34 organisms organism NNS cord-022053-idft1p6d 432 35 from from IN cord-022053-idft1p6d 432 36 specimens specimen NNS cord-022053-idft1p6d 432 37 in in IN cord-022053-idft1p6d 432 38 which which WDT cord-022053-idft1p6d 432 39 culture culture NN cord-022053-idft1p6d 432 40 is be VBZ cord-022053-idft1p6d 432 41 not not RB cord-022053-idft1p6d 432 42 possible possible JJ cord-022053-idft1p6d 432 43 or or CC cord-022053-idft1p6d 432 44 has have VBZ cord-022053-idft1p6d 432 45 failed fail VBN cord-022053-idft1p6d 432 46 , , , cord-022053-idft1p6d 432 47 such such JJ cord-022053-idft1p6d 432 48 as as IN cord-022053-idft1p6d 432 49 in in IN cord-022053-idft1p6d 432 50 specimens specimen NNS cord-022053-idft1p6d 432 51 from from IN cord-022053-idft1p6d 432 52 antibiotictreated antibiotictreated JJ cord-022053-idft1p6d 432 53 patients patient NNS cord-022053-idft1p6d 432 54 and and CC cord-022053-idft1p6d 432 55 fixed fix VBN cord-022053-idft1p6d 432 56 specimens specimen NNS cord-022053-idft1p6d 432 57 . . . cord-022053-idft1p6d 433 1 [ [ -LRB- cord-022053-idft1p6d 433 2 127 127 CD cord-022053-idft1p6d 433 3 ] ] -RRB- cord-022053-idft1p6d 433 4 [ [ -LRB- cord-022053-idft1p6d 433 5 128 128 CD cord-022053-idft1p6d 433 6 ] ] -RRB- cord-022053-idft1p6d 433 7 [ [ -LRB- cord-022053-idft1p6d 433 8 129 129 CD cord-022053-idft1p6d 433 9 ] ] -RRB- cord-022053-idft1p6d 434 1 [ [ -LRB- cord-022053-idft1p6d 434 2 130 130 CD cord-022053-idft1p6d 434 3 ] ] -RRB- cord-022053-idft1p6d 435 1 For for IN cord-022053-idft1p6d 435 2 example example NN cord-022053-idft1p6d 435 3 , , , cord-022053-idft1p6d 435 4 the the DT cord-022053-idft1p6d 435 5 identification identification NN cord-022053-idft1p6d 435 6 of of IN cord-022053-idft1p6d 435 7 mycobacterial mycobacterial JJ cord-022053-idft1p6d 435 8 species specie NNS cord-022053-idft1p6d 435 9 identified identify VBN cord-022053-idft1p6d 435 10 by by IN cord-022053-idft1p6d 435 11 acid acid NN cord-022053-idft1p6d 435 12 - - HYPH cord-022053-idft1p6d 435 13 fast fast JJ cord-022053-idft1p6d 435 14 staining staining NN cord-022053-idft1p6d 435 15 of of IN cord-022053-idft1p6d 435 16 FFPE FFPE NNP cord-022053-idft1p6d 435 17 is be VBZ cord-022053-idft1p6d 435 18 a a DT cord-022053-idft1p6d 435 19 commonly commonly RB cord-022053-idft1p6d 435 20 used use VBN cord-022053-idft1p6d 435 21 application application NN cord-022053-idft1p6d 435 22 of of IN cord-022053-idft1p6d 435 23 16S 16S NNP cord-022053-idft1p6d 435 24 sequencing sequencing NN cord-022053-idft1p6d 435 25 , , , cord-022053-idft1p6d 435 26 although although IN cord-022053-idft1p6d 435 27 additional additional JJ cord-022053-idft1p6d 435 28 targets target NNS cord-022053-idft1p6d 435 29 , , , cord-022053-idft1p6d 435 30 such such JJ cord-022053-idft1p6d 435 31 as as IN cord-022053-idft1p6d 435 32 IS6110 IS6110 NNS cord-022053-idft1p6d 435 33 and and CC cord-022053-idft1p6d 435 34 hsp65 hsp65 NNS cord-022053-idft1p6d 435 35 , , , cord-022053-idft1p6d 435 36 are be VBP cord-022053-idft1p6d 435 37 often often RB cord-022053-idft1p6d 435 38 needed need VBN cord-022053-idft1p6d 435 39 to to TO cord-022053-idft1p6d 435 40 differentiate differentiate VB cord-022053-idft1p6d 435 41 species specie NNS cord-022053-idft1p6d 435 42 . . . cord-022053-idft1p6d 436 1 131 131 CD cord-022053-idft1p6d 436 2 , , , cord-022053-idft1p6d 436 3 132 132 CD cord-022053-idft1p6d 436 4 Specimen Specimen NNP cord-022053-idft1p6d 436 5 types type NNS cord-022053-idft1p6d 436 6 most most RBS cord-022053-idft1p6d 436 7 successfully successfully RB cord-022053-idft1p6d 436 8 analyzed analyze VBN cord-022053-idft1p6d 436 9 by by IN cord-022053-idft1p6d 436 10 direct direct JJ cord-022053-idft1p6d 436 11 16Sseq 16sseq CD cord-022053-idft1p6d 436 12 include include VBP cord-022053-idft1p6d 436 13 heart heart NN cord-022053-idft1p6d 436 14 valves valve NNS cord-022053-idft1p6d 436 15 , , , cord-022053-idft1p6d 436 16 CSF CSF NNP cord-022053-idft1p6d 436 17 , , , cord-022053-idft1p6d 436 18 and and CC cord-022053-idft1p6d 436 19 synovial synovial JJ cord-022053-idft1p6d 436 20 fluid fluid NN cord-022053-idft1p6d 436 21 . . . cord-022053-idft1p6d 437 1 [ [ -LRB- cord-022053-idft1p6d 437 2 133 133 CD cord-022053-idft1p6d 437 3 ] ] -RRB- cord-022053-idft1p6d 437 4 [ [ -LRB- cord-022053-idft1p6d 437 5 134 134 CD cord-022053-idft1p6d 437 6 ] ] -RRB- cord-022053-idft1p6d 437 7 [ [ -LRB- cord-022053-idft1p6d 437 8 135 135 CD cord-022053-idft1p6d 437 9 ] ] -RRB- cord-022053-idft1p6d 437 10 [ [ -LRB- cord-022053-idft1p6d 437 11 136 136 CD cord-022053-idft1p6d 437 12 ] ] -RRB- cord-022053-idft1p6d 437 13 [ [ -LRB- cord-022053-idft1p6d 437 14 137 137 CD cord-022053-idft1p6d 437 15 ] ] -RRB- cord-022053-idft1p6d 437 16 [ [ -LRB- cord-022053-idft1p6d 437 17 138 138 CD cord-022053-idft1p6d 437 18 ] ] -RRB- cord-022053-idft1p6d 438 1 Fungal fungal JJ cord-022053-idft1p6d 438 2 pathogens pathogen NNS cord-022053-idft1p6d 438 3 are be VBP cord-022053-idft1p6d 438 4 also also RB cord-022053-idft1p6d 438 5 identified identify VBN cord-022053-idft1p6d 438 6 using use VBG cord-022053-idft1p6d 438 7 rRNA rrna JJ cord-022053-idft1p6d 438 8 sequencing sequencing NN cord-022053-idft1p6d 438 9 , , , cord-022053-idft1p6d 438 10 although although IN cord-022053-idft1p6d 438 11 it -PRON- PRP cord-022053-idft1p6d 438 12 is be VBZ cord-022053-idft1p6d 438 13 a a DT cord-022053-idft1p6d 438 14 less less RBR cord-022053-idft1p6d 438 15 established established JJ cord-022053-idft1p6d 438 16 practice practice NN cord-022053-idft1p6d 438 17 than than IN cord-022053-idft1p6d 438 18 it -PRON- PRP cord-022053-idft1p6d 438 19 is be VBZ cord-022053-idft1p6d 438 20 for for IN cord-022053-idft1p6d 438 21 bacterial bacterial JJ cord-022053-idft1p6d 438 22 targets target NNS cord-022053-idft1p6d 438 23 . . . cord-022053-idft1p6d 439 1 The the DT cord-022053-idft1p6d 439 2 fungal fungal NN cord-022053-idft1p6d 439 3 rRNA rRNA NNP cord-022053-idft1p6d 439 4 18S 18S NNPS cord-022053-idft1p6d 439 5 corresponds correspond VBZ cord-022053-idft1p6d 439 6 to to IN cord-022053-idft1p6d 439 7 bacterial bacterial JJ cord-022053-idft1p6d 439 8 16S 16S NNPS cord-022053-idft1p6d 439 9 , , , cord-022053-idft1p6d 439 10 although although IN cord-022053-idft1p6d 439 11 it -PRON- PRP cord-022053-idft1p6d 439 12 has have VBZ cord-022053-idft1p6d 439 13 fewer few JJR cord-022053-idft1p6d 439 14 hypervariable hypervariable JJ cord-022053-idft1p6d 439 15 regions region NNS cord-022053-idft1p6d 439 16 and and CC cord-022053-idft1p6d 439 17 is be VBZ cord-022053-idft1p6d 439 18 generally generally RB cord-022053-idft1p6d 439 19 not not RB cord-022053-idft1p6d 439 20 as as RB cord-022053-idft1p6d 439 21 useful useful JJ cord-022053-idft1p6d 439 22 for for IN cord-022053-idft1p6d 439 23 isolate isolate NN cord-022053-idft1p6d 439 24 discrimination discrimination NN cord-022053-idft1p6d 439 25 . . . cord-022053-idft1p6d 440 1 139 139 CD cord-022053-idft1p6d 441 1 The the DT cord-022053-idft1p6d 441 2 most most RBS cord-022053-idft1p6d 441 3 common common JJ cord-022053-idft1p6d 441 4 regions region NNS cord-022053-idft1p6d 441 5 for for IN cord-022053-idft1p6d 441 6 fungal fungal JJ cord-022053-idft1p6d 441 7 identification identification NN cord-022053-idft1p6d 441 8 are be VBP cord-022053-idft1p6d 441 9 the the DT cord-022053-idft1p6d 441 10 ITS its PRP$ cord-022053-idft1p6d 441 11 regions region NNS cord-022053-idft1p6d 441 12 1 1 CD cord-022053-idft1p6d 441 13 and and CC cord-022053-idft1p6d 441 14 2 2 CD cord-022053-idft1p6d 441 15 , , , cord-022053-idft1p6d 441 16 as as RB cord-022053-idft1p6d 441 17 well well RB cord-022053-idft1p6d 441 18 as as IN cord-022053-idft1p6d 441 19 the the DT cord-022053-idft1p6d 441 20 D1 d1 NN cord-022053-idft1p6d 441 21 and and CC cord-022053-idft1p6d 441 22 D2 d2 NN cord-022053-idft1p6d 441 23 hypervariable hypervariable JJ cord-022053-idft1p6d 441 24 regions region NNS cord-022053-idft1p6d 441 25 of of IN cord-022053-idft1p6d 441 26 the the DT cord-022053-idft1p6d 441 27 28S 28S NNP cord-022053-idft1p6d 441 28 rRNA rRNA NNP cord-022053-idft1p6d 441 29 large large JJ cord-022053-idft1p6d 441 30 subunit subunit NN cord-022053-idft1p6d 441 31 component component NN cord-022053-idft1p6d 441 32 ( ( -LRB- cord-022053-idft1p6d 441 33 Fig Fig NNP cord-022053-idft1p6d 441 34 . . . cord-022053-idft1p6d 441 35 6.2 6.2 CD cord-022053-idft1p6d 441 36 ) ) -RRB- cord-022053-idft1p6d 441 37 . . . cord-022053-idft1p6d 442 1 [ [ -LRB- cord-022053-idft1p6d 442 2 139 139 CD cord-022053-idft1p6d 442 3 ] ] -RRB- cord-022053-idft1p6d 442 4 [ [ -LRB- cord-022053-idft1p6d 442 5 140 140 CD cord-022053-idft1p6d 442 6 ] ] -RRB- cord-022053-idft1p6d 443 1 [ [ -LRB- cord-022053-idft1p6d 443 2 141 141 CD cord-022053-idft1p6d 443 3 ] ] -RRB- cord-022053-idft1p6d 444 1 When when WRB cord-022053-idft1p6d 444 2 using use VBG cord-022053-idft1p6d 444 3 these these DT cord-022053-idft1p6d 444 4 targets target NNS cord-022053-idft1p6d 444 5 to to TO cord-022053-idft1p6d 444 6 identify identify VB cord-022053-idft1p6d 444 7 an an DT cord-022053-idft1p6d 444 8 isolate isolate NN cord-022053-idft1p6d 444 9 , , , cord-022053-idft1p6d 444 10 criteria criterion NNS cord-022053-idft1p6d 444 11 required require VBN cord-022053-idft1p6d 444 12 for for IN cord-022053-idft1p6d 444 13 percentage percentage NN cord-022053-idft1p6d 444 14 identity identity NN cord-022053-idft1p6d 444 15 and and CC cord-022053-idft1p6d 444 16 percentage percentage NN cord-022053-idft1p6d 444 17 difference difference NN cord-022053-idft1p6d 444 18 between between IN cord-022053-idft1p6d 444 19 competing compete VBG cord-022053-idft1p6d 444 20 matches match NNS cord-022053-idft1p6d 444 21 are be VBP cord-022053-idft1p6d 444 22 not not RB cord-022053-idft1p6d 444 23 as as RB cord-022053-idft1p6d 444 24 clear clear JJ cord-022053-idft1p6d 444 25 for for IN cord-022053-idft1p6d 444 26 fungi fungus NNS cord-022053-idft1p6d 444 27 as as IN cord-022053-idft1p6d 444 28 they -PRON- PRP cord-022053-idft1p6d 444 29 are be VBP cord-022053-idft1p6d 444 30 for for IN cord-022053-idft1p6d 444 31 bacteria bacteria NNS cord-022053-idft1p6d 444 32 . . . cord-022053-idft1p6d 445 1 126 126 CD cord-022053-idft1p6d 446 1 The the DT cord-022053-idft1p6d 446 2 lack lack NN cord-022053-idft1p6d 446 3 of of IN cord-022053-idft1p6d 446 4 high high JJ cord-022053-idft1p6d 446 5 - - HYPH cord-022053-idft1p6d 446 6 quality quality NN cord-022053-idft1p6d 446 7 databases database NNS cord-022053-idft1p6d 446 8 has have VBZ cord-022053-idft1p6d 446 9 been be VBN cord-022053-idft1p6d 446 10 a a DT cord-022053-idft1p6d 446 11 major major JJ cord-022053-idft1p6d 446 12 difficulty difficulty NN cord-022053-idft1p6d 446 13 in in IN cord-022053-idft1p6d 446 14 fungal fungal JJ cord-022053-idft1p6d 446 15 sequencing sequencing NN cord-022053-idft1p6d 446 16 , , , cord-022053-idft1p6d 446 17 with with IN cord-022053-idft1p6d 446 18 estimates estimate NNS cord-022053-idft1p6d 446 19 of of IN cord-022053-idft1p6d 446 20 up up IN cord-022053-idft1p6d 446 21 to to TO cord-022053-idft1p6d 446 22 20 20 CD cord-022053-idft1p6d 446 23 % % NN cord-022053-idft1p6d 446 24 of of IN cord-022053-idft1p6d 446 25 the the DT cord-022053-idft1p6d 446 26 entries entry NNS cord-022053-idft1p6d 446 27 in in IN cord-022053-idft1p6d 446 28 GenBank GenBank NNP cord-022053-idft1p6d 446 29 being be VBG cord-022053-idft1p6d 446 30 incorrectly incorrectly RB cord-022053-idft1p6d 446 31 identified identify VBN cord-022053-idft1p6d 446 32 down down RP cord-022053-idft1p6d 446 33 to to IN cord-022053-idft1p6d 446 34 species species NN cord-022053-idft1p6d 446 35 level level NN cord-022053-idft1p6d 446 36 . . . cord-022053-idft1p6d 447 1 142 142 CD cord-022053-idft1p6d 448 1 To to TO cord-022053-idft1p6d 448 2 address address VB cord-022053-idft1p6d 448 3 this this DT cord-022053-idft1p6d 448 4 , , , cord-022053-idft1p6d 448 5 several several JJ cord-022053-idft1p6d 448 6 of of IN cord-022053-idft1p6d 448 7 the the DT cord-022053-idft1p6d 448 8 private private JJ cord-022053-idft1p6d 448 9 databases database NNS cord-022053-idft1p6d 448 10 that that WDT cord-022053-idft1p6d 448 11 are be VBP cord-022053-idft1p6d 448 12 available available JJ cord-022053-idft1p6d 448 13 for for IN cord-022053-idft1p6d 448 14 bacterial bacterial JJ cord-022053-idft1p6d 448 15 sequencing sequencing NN cord-022053-idft1p6d 448 16 also also RB cord-022053-idft1p6d 448 17 include include VBP cord-022053-idft1p6d 448 18 curated curate VBN cord-022053-idft1p6d 448 19 or or CC cord-022053-idft1p6d 448 20 partially partially RB cord-022053-idft1p6d 448 21 curated curate VBN cord-022053-idft1p6d 448 22 fungal fungal NN cord-022053-idft1p6d 448 23 databases database NNS cord-022053-idft1p6d 448 24 ( ( -LRB- cord-022053-idft1p6d 448 25 IDNS IDNS NNP cord-022053-idft1p6d 448 26 and and CC cord-022053-idft1p6d 448 27 RipSeq RipSeq NNP cord-022053-idft1p6d 448 28 ) ) -RRB- cord-022053-idft1p6d 448 29 . . . cord-022053-idft1p6d 449 1 143 143 CD cord-022053-idft1p6d 450 1 The the DT cord-022053-idft1p6d 450 2 MicroSEQ microseq NN cord-022053-idft1p6d 450 3 system system NN cord-022053-idft1p6d 450 4 also also RB cord-022053-idft1p6d 450 5 includes include VBZ cord-022053-idft1p6d 450 6 a a DT cord-022053-idft1p6d 450 7 fungal fungal JJ cord-022053-idft1p6d 450 8 component component NN cord-022053-idft1p6d 450 9 , , , cord-022053-idft1p6d 450 10 but but CC cord-022053-idft1p6d 450 11 it -PRON- PRP cord-022053-idft1p6d 450 12 is be VBZ cord-022053-idft1p6d 450 13 limited limit VBN cord-022053-idft1p6d 450 14 to to IN cord-022053-idft1p6d 450 15 the the DT cord-022053-idft1p6d 450 16 D2 d2 NN cord-022053-idft1p6d 450 17 region region NN cord-022053-idft1p6d 450 18 of of IN cord-022053-idft1p6d 450 19 28S. 28s. CD cord-022053-idft1p6d 451 1 Recently recently RB cord-022053-idft1p6d 451 2 , , , cord-022053-idft1p6d 451 3 several several JJ cord-022053-idft1p6d 451 4 public public JJ cord-022053-idft1p6d 451 5 databases database NNS cord-022053-idft1p6d 451 6 have have VBP cord-022053-idft1p6d 451 7 become become VBN cord-022053-idft1p6d 451 8 available available JJ cord-022053-idft1p6d 451 9 with with IN cord-022053-idft1p6d 451 10 high high JJ cord-022053-idft1p6d 451 11 - - HYPH cord-022053-idft1p6d 451 12 quality quality NN cord-022053-idft1p6d 451 13 , , , cord-022053-idft1p6d 451 14 curated curate VBN cord-022053-idft1p6d 451 15 content content NN cord-022053-idft1p6d 451 16 . . . cord-022053-idft1p6d 452 1 Databases database NNS cord-022053-idft1p6d 452 2 that that WDT cord-022053-idft1p6d 452 3 are be VBP cord-022053-idft1p6d 452 4 most most RBS cord-022053-idft1p6d 452 5 focused focus VBN cord-022053-idft1p6d 452 6 on on IN cord-022053-idft1p6d 452 7 species specie NNS cord-022053-idft1p6d 452 8 of of IN cord-022053-idft1p6d 452 9 medical medical JJ cord-022053-idft1p6d 452 10 importance importance NN cord-022053-idft1p6d 452 11 include include VBP cord-022053-idft1p6d 452 12 the the DT cord-022053-idft1p6d 452 13 International International NNP cord-022053-idft1p6d 452 14 Society Society NNP cord-022053-idft1p6d 452 15 for for IN cord-022053-idft1p6d 452 16 Human Human NNP cord-022053-idft1p6d 452 17 and and CC cord-022053-idft1p6d 452 18 Animal Animal NNP cord-022053-idft1p6d 452 19 Mycology Mycology NNP cord-022053-idft1p6d 452 20 ( ( -LRB- cord-022053-idft1p6d 452 21 ISHAM ISHAM NNP cord-022053-idft1p6d 452 22 ) ) -RRB- cord-022053-idft1p6d 453 1 ITS its PRP$ cord-022053-idft1p6d 453 2 database database NN cord-022053-idft1p6d 453 3 contains contain VBZ cord-022053-idft1p6d 453 4 3200 3200 CD cord-022053-idft1p6d 453 5 sequences sequence NNS cord-022053-idft1p6d 453 6 representing represent VBG cord-022053-idft1p6d 453 7 524 524 CD cord-022053-idft1p6d 453 8 human/ human/ CD cord-022053-idft1p6d 453 9 animal animal NN cord-022053-idft1p6d 453 10 pathogenic pathogenic JJ cord-022053-idft1p6d 453 11 fungal fungal JJ cord-022053-idft1p6d 453 12 species specie NNS cord-022053-idft1p6d 453 13 and and CC cord-022053-idft1p6d 453 14 is be VBZ cord-022053-idft1p6d 453 15 a a DT cord-022053-idft1p6d 453 16 major major JJ cord-022053-idft1p6d 453 17 resource resource NN cord-022053-idft1p6d 453 18 for for IN cord-022053-idft1p6d 453 19 clinical clinical JJ cord-022053-idft1p6d 453 20 laboratories laboratory NNS cord-022053-idft1p6d 453 21 . . . cord-022053-idft1p6d 454 1 144 144 CD cord-022053-idft1p6d 455 1 It -PRON- PRP cord-022053-idft1p6d 455 2 can can MD cord-022053-idft1p6d 455 3 be be VB cord-022053-idft1p6d 455 4 searched search VBN cord-022053-idft1p6d 455 5 via via IN cord-022053-idft1p6d 455 6 a a DT cord-022053-idft1p6d 455 7 web web NN cord-022053-idft1p6d 455 8 - - HYPH cord-022053-idft1p6d 455 9 based base VBN cord-022053-idft1p6d 455 10 platform platform NN cord-022053-idft1p6d 455 11 ( ( -LRB- cord-022053-idft1p6d 455 12 its.mycologylab.org its.mycologylab.org NN cord-022053-idft1p6d 455 13 ) ) -RRB- cord-022053-idft1p6d 455 14 . . . cord-022053-idft1p6d 456 1 The the DT cord-022053-idft1p6d 456 2 National National NNP cord-022053-idft1p6d 456 3 Center Center NNP cord-022053-idft1p6d 456 4 for for IN cord-022053-idft1p6d 456 5 Biotechnology Biotechnology NNP cord-022053-idft1p6d 456 6 Information Information NNP cord-022053-idft1p6d 456 7 RefSeq RefSeq NNP cord-022053-idft1p6d 457 1 ITS its PRP$ cord-022053-idft1p6d 457 2 database database NN cord-022053-idft1p6d 457 3 contains contain VBZ cord-022053-idft1p6d 457 4 3060 3060 CD cord-022053-idft1p6d 457 5 sequences sequence NNS cord-022053-idft1p6d 457 6 representing represent VBG cord-022053-idft1p6d 457 7 270 270 CD cord-022053-idft1p6d 457 8 families family NNS cord-022053-idft1p6d 457 9 from from IN cord-022053-idft1p6d 457 10 39 39 CD cord-022053-idft1p6d 457 11 classes class NNS cord-022053-idft1p6d 457 12 . . . cord-022053-idft1p6d 458 1 The the DT cord-022053-idft1p6d 458 2 smaller small JJR cord-022053-idft1p6d 458 3 28S 28S NNP cord-022053-idft1p6d 458 4 RefSeq RefSeq NNP cord-022053-idft1p6d 458 5 database database NN cord-022053-idft1p6d 458 6 contains contain VBZ cord-022053-idft1p6d 458 7 approximately approximately RB cord-022053-idft1p6d 458 8 500 500 CD cord-022053-idft1p6d 458 9 , , , cord-022053-idft1p6d 458 10 representing represent VBG cord-022053-idft1p6d 458 11 greater great JJR cord-022053-idft1p6d 458 12 than than IN cord-022053-idft1p6d 458 13 100 100 CD cord-022053-idft1p6d 458 14 families family NNS cord-022053-idft1p6d 458 15 from from IN cord-022053-idft1p6d 458 16 21 21 CD cord-022053-idft1p6d 458 17 classes class NNS cord-022053-idft1p6d 458 18 . . . cord-022053-idft1p6d 459 1 145 145 CD cord-022053-idft1p6d 460 1 This this DT cord-022053-idft1p6d 460 2 technique technique NN cord-022053-idft1p6d 460 3 is be VBZ cord-022053-idft1p6d 460 4 particularly particularly RB cord-022053-idft1p6d 460 5 promising promising JJ cord-022053-idft1p6d 460 6 for for IN cord-022053-idft1p6d 460 7 identifying identify VBG cord-022053-idft1p6d 460 8 fungi fungus NNS cord-022053-idft1p6d 460 9 from from IN cord-022053-idft1p6d 460 10 fixed fix VBN cord-022053-idft1p6d 460 11 tissue tissue NN cord-022053-idft1p6d 460 12 . . . cord-022053-idft1p6d 461 1 55 55 CD cord-022053-idft1p6d 461 2 , , , cord-022053-idft1p6d 461 3 146 146 CD cord-022053-idft1p6d 461 4 , , , cord-022053-idft1p6d 461 5 147 147 CD cord-022053-idft1p6d 461 6 Important important JJ cord-022053-idft1p6d 461 7 caveats caveat NNS cord-022053-idft1p6d 461 8 of of IN cord-022053-idft1p6d 461 9 rRNA rrna JJ cord-022053-idft1p6d 461 10 sequencing sequencing NN cord-022053-idft1p6d 461 11 include include VBP cord-022053-idft1p6d 461 12 high high JJ cord-022053-idft1p6d 461 13 cost cost NN cord-022053-idft1p6d 461 14 and and CC cord-022053-idft1p6d 461 15 complexity complexity NN cord-022053-idft1p6d 461 16 , , , cord-022053-idft1p6d 461 17 issues issue NNS cord-022053-idft1p6d 461 18 with with IN cord-022053-idft1p6d 461 19 uncurated uncurated JJ cord-022053-idft1p6d 461 20 databases database NNS cord-022053-idft1p6d 461 21 ( ( -LRB- cord-022053-idft1p6d 461 22 described describe VBN cord-022053-idft1p6d 461 23 above above IN cord-022053-idft1p6d 461 24 ) ) -RRB- cord-022053-idft1p6d 461 25 , , , cord-022053-idft1p6d 461 26 and and CC cord-022053-idft1p6d 461 27 the the DT cord-022053-idft1p6d 461 28 potential potential NN cord-022053-idft1p6d 461 29 for for IN cord-022053-idft1p6d 461 30 false false JJ cord-022053-idft1p6d 461 31 positives positive NNS cord-022053-idft1p6d 461 32 . . . cord-022053-idft1p6d 462 1 This this DT cord-022053-idft1p6d 462 2 is be VBZ cord-022053-idft1p6d 462 3 particularly particularly RB cord-022053-idft1p6d 462 4 the the DT cord-022053-idft1p6d 462 5 case case NN cord-022053-idft1p6d 462 6 when when WRB cord-022053-idft1p6d 462 7 broad broad JJ cord-022053-idft1p6d 462 8 - - HYPH cord-022053-idft1p6d 462 9 range range NN cord-022053-idft1p6d 462 10 sequencing sequencing NN cord-022053-idft1p6d 462 11 is be VBZ cord-022053-idft1p6d 462 12 applied apply VBN cord-022053-idft1p6d 462 13 to to IN cord-022053-idft1p6d 462 14 primary primary JJ cord-022053-idft1p6d 462 15 specimens specimen NNS cord-022053-idft1p6d 462 16 to to TO cord-022053-idft1p6d 462 17 " " `` cord-022053-idft1p6d 462 18 fish fish NN cord-022053-idft1p6d 462 19 " " '' cord-022053-idft1p6d 462 20 for for IN cord-022053-idft1p6d 462 21 an an DT cord-022053-idft1p6d 462 22 infectious infectious JJ cord-022053-idft1p6d 462 23 agent agent NN cord-022053-idft1p6d 462 24 in in IN cord-022053-idft1p6d 462 25 the the DT cord-022053-idft1p6d 462 26 absence absence NN cord-022053-idft1p6d 462 27 of of IN cord-022053-idft1p6d 462 28 any any DT cord-022053-idft1p6d 462 29 corroborating corroborate VBG cord-022053-idft1p6d 462 30 culture culture NN cord-022053-idft1p6d 462 31 or or CC cord-022053-idft1p6d 462 32 gram gram NN cord-022053-idft1p6d 462 33 stain stain NN cord-022053-idft1p6d 462 34 . . . cord-022053-idft1p6d 463 1 Furthermore furthermore RB cord-022053-idft1p6d 463 2 , , , cord-022053-idft1p6d 463 3 rRNA rrna NN cord-022053-idft1p6d 463 4 should should MD cord-022053-idft1p6d 463 5 not not RB cord-022053-idft1p6d 463 6 be be VB cord-022053-idft1p6d 463 7 used use VBN cord-022053-idft1p6d 463 8 to to TO cord-022053-idft1p6d 463 9 determine determine VB cord-022053-idft1p6d 463 10 whether whether IN cord-022053-idft1p6d 463 11 an an DT cord-022053-idft1p6d 463 12 infection infection NN cord-022053-idft1p6d 463 13 has have VBZ cord-022053-idft1p6d 463 14 " " `` cord-022053-idft1p6d 463 15 cleared clear VBN cord-022053-idft1p6d 463 16 , , , cord-022053-idft1p6d 463 17 " " '' cord-022053-idft1p6d 463 18 due due IN cord-022053-idft1p6d 463 19 to to IN cord-022053-idft1p6d 463 20 the the DT cord-022053-idft1p6d 463 21 potential potential NN cord-022053-idft1p6d 463 22 for for IN cord-022053-idft1p6d 463 23 lingering linger VBG cord-022053-idft1p6d 463 24 nucleic nucleic JJ cord-022053-idft1p6d 463 25 acid acid NN cord-022053-idft1p6d 463 26 even even RB cord-022053-idft1p6d 463 27 in in IN cord-022053-idft1p6d 463 28 a a DT cord-022053-idft1p6d 463 29 successfully successfully RB cord-022053-idft1p6d 463 30 treated treat VBN cord-022053-idft1p6d 463 31 infection infection NN cord-022053-idft1p6d 463 32 . . . cord-022053-idft1p6d 464 1 Analysis analysis NN cord-022053-idft1p6d 464 2 should should MD cord-022053-idft1p6d 464 3 be be VB cord-022053-idft1p6d 464 4 restricted restrict VBN cord-022053-idft1p6d 464 5 to to IN cord-022053-idft1p6d 464 6 normally normally RB cord-022053-idft1p6d 464 7 sterile sterile JJ cord-022053-idft1p6d 464 8 sites site NNS cord-022053-idft1p6d 464 9 for for IN cord-022053-idft1p6d 464 10 tests test NNS cord-022053-idft1p6d 464 11 using use VBG cord-022053-idft1p6d 464 12 In in IN cord-022053-idft1p6d 464 13 FFPE FFPE NNP cord-022053-idft1p6d 464 14 in in IN cord-022053-idft1p6d 464 15 which which WDT cord-022053-idft1p6d 464 16 an an DT cord-022053-idft1p6d 464 17 organism organism NN cord-022053-idft1p6d 464 18 has have VBZ cord-022053-idft1p6d 464 19 been be VBN cord-022053-idft1p6d 464 20 seen see VBN cord-022053-idft1p6d 464 21 but but CC cord-022053-idft1p6d 464 22 not not RB cord-022053-idft1p6d 464 23 identified identify VBN cord-022053-idft1p6d 464 24 ( ( -LRB- cord-022053-idft1p6d 464 25 such such JJ cord-022053-idft1p6d 464 26 as as IN cord-022053-idft1p6d 464 27 bacteria bacteria NNS cord-022053-idft1p6d 464 28 , , , cord-022053-idft1p6d 464 29 fungal fungal JJ cord-022053-idft1p6d 464 30 elements element NNS cord-022053-idft1p6d 464 31 , , , cord-022053-idft1p6d 464 32 viral viral JJ cord-022053-idft1p6d 464 33 cytopathic cytopathic JJ cord-022053-idft1p6d 464 34 or or CC cord-022053-idft1p6d 464 35 necrotic necrotic JJ cord-022053-idft1p6d 464 36 effect effect NN cord-022053-idft1p6d 464 37 , , , cord-022053-idft1p6d 464 38 or or CC cord-022053-idft1p6d 464 39 unidentified unidentified JJ cord-022053-idft1p6d 464 40 parasitic parasitic JJ cord-022053-idft1p6d 464 41 elements element NNS cord-022053-idft1p6d 464 42 ) ) -RRB- cord-022053-idft1p6d 464 43 , , , cord-022053-idft1p6d 464 44 NGS NGS NNP cord-022053-idft1p6d 464 45 has have VBZ cord-022053-idft1p6d 464 46 enormous enormous JJ cord-022053-idft1p6d 464 47 potential potential NN cord-022053-idft1p6d 464 48 to to TO cord-022053-idft1p6d 464 49 rectify rectify VB cord-022053-idft1p6d 464 50 these these DT cord-022053-idft1p6d 464 51 s s NNS cord-022053-idft1p6d 464 52 diagnoses diagnosis NNS cord-022053-idft1p6d 464 53 but but CC cord-022053-idft1p6d 464 54 is be VBZ cord-022053-idft1p6d 464 55 currently currently RB cord-022053-idft1p6d 464 56 limited limit VBN cord-022053-idft1p6d 464 57 by by IN cord-022053-idft1p6d 464 58 cost cost NN cord-022053-idft1p6d 464 59 per per IN cord-022053-idft1p6d 464 60 sample sample NN cord-022053-idft1p6d 464 61 and and CC cord-022053-idft1p6d 464 62 the the DT cord-022053-idft1p6d 464 63 enormous enormous JJ cord-022053-idft1p6d 464 64 amounts amount NNS cord-022053-idft1p6d 464 65 of of IN cord-022053-idft1p6d 464 66 raw raw JJ cord-022053-idft1p6d 464 67 human human JJ cord-022053-idft1p6d 464 68 data datum NNS cord-022053-idft1p6d 464 69 in in IN cord-022053-idft1p6d 464 70 comparison comparison NN cord-022053-idft1p6d 464 71 with with IN cord-022053-idft1p6d 464 72 the the DT cord-022053-idft1p6d 464 73 relatively relatively RB cord-022053-idft1p6d 464 74 small small JJ cord-022053-idft1p6d 464 75 amount amount NN cord-022053-idft1p6d 464 76 of of IN cord-022053-idft1p6d 464 77 the the DT cord-022053-idft1p6d 464 78 organism organism NN cord-022053-idft1p6d 464 79 's 's POS cord-022053-idft1p6d 464 80 sequence sequence NN cord-022053-idft1p6d 464 81 . . . cord-022053-idft1p6d 465 1 As as IN cord-022053-idft1p6d 465 2 costs cost NNS cord-022053-idft1p6d 465 3 fall fall VBP cord-022053-idft1p6d 465 4 for for IN cord-022053-idft1p6d 465 5 sequencing sequence VBG cord-022053-idft1p6d 465 6 and and CC cord-022053-idft1p6d 465 7 rapid rapid JJ cord-022053-idft1p6d 465 8 bioinformatic bioinformatic JJ cord-022053-idft1p6d 465 9 methods method NNS cord-022053-idft1p6d 465 10 for for IN cord-022053-idft1p6d 465 11 elucidating elucidate VBG cord-022053-idft1p6d 465 12 causative causative JJ cord-022053-idft1p6d 465 13 sequence sequence NN cord-022053-idft1p6d 465 14 emerge emerge VB cord-022053-idft1p6d 465 15 , , , cord-022053-idft1p6d 465 16 NGS NGS NNP cord-022053-idft1p6d 465 17 will will MD cord-022053-idft1p6d 465 18 become become VB cord-022053-idft1p6d 465 19 a a DT cord-022053-idft1p6d 465 20 primary primary JJ cord-022053-idft1p6d 465 21 tool tool NN cord-022053-idft1p6d 465 22 for for IN cord-022053-idft1p6d 465 23 confirmation confirmation NN cord-022053-idft1p6d 465 24 of of IN cord-022053-idft1p6d 465 25 microbial microbial JJ cord-022053-idft1p6d 465 26 infections infection NNS cord-022053-idft1p6d 465 27 . . . cord-022053-idft1p6d 466 1 One one CD cord-022053-idft1p6d 466 2 last last JJ cord-022053-idft1p6d 466 3 technology technology NN cord-022053-idft1p6d 466 4 to to TO cord-022053-idft1p6d 466 5 consider consider VB cord-022053-idft1p6d 466 6 is be VBZ cord-022053-idft1p6d 466 7 the the DT cord-022053-idft1p6d 466 8 hybrid hybrid JJ cord-022053-idft1p6d 466 9 system system NN cord-022053-idft1p6d 466 10 , , , cord-022053-idft1p6d 466 11 PLEX PLEX NNP cord-022053-idft1p6d 466 12 - - HYPH cord-022053-idft1p6d 466 13 ID ID NNP cord-022053-idft1p6d 466 14 by by IN cord-022053-idft1p6d 466 15 Abbott Abbott NNP cord-022053-idft1p6d 466 16 , , , cord-022053-idft1p6d 466 17 which which WDT cord-022053-idft1p6d 466 18 combines combine VBZ cord-022053-idft1p6d 466 19 a a DT cord-022053-idft1p6d 466 20 PCR PCR NNP cord-022053-idft1p6d 466 21 step step NN cord-022053-idft1p6d 466 22 to to TO cord-022053-idft1p6d 466 23 amplify amplify VB cord-022053-idft1p6d 466 24 through through IN cord-022053-idft1p6d 466 25 a a DT cord-022053-idft1p6d 466 26 set set NN cord-022053-idft1p6d 466 27 of of IN cord-022053-idft1p6d 466 28 primers primer NNS cord-022053-idft1p6d 466 29 ( ( -LRB- cord-022053-idft1p6d 466 30 PLEX PLEX NNP cord-022053-idft1p6d 466 31 - - HYPH cord-022053-idft1p6d 466 32 ID ID NNP cord-022053-idft1p6d 466 33 Viral Viral NNP cord-022053-idft1p6d 466 34 IC IC NNP cord-022053-idft1p6d 466 35 , , , cord-022053-idft1p6d 466 36 PLEX PLEX NNP cord-022053-idft1p6d 466 37 - - HYPH cord-022053-idft1p6d 466 38 ID ID NNP cord-022053-idft1p6d 466 39 BAC BAC NNP cord-022053-idft1p6d 466 40 Spectrum Spectrum NNP cord-022053-idft1p6d 466 41 BC BC NNP cord-022053-idft1p6d 466 42 , , , cord-022053-idft1p6d 466 43 or or CC cord-022053-idft1p6d 466 44 PLEX PLEX NNP cord-022053-idft1p6d 466 45 - - HYPH cord-022053-idft1p6d 466 46 ID ID NNP cord-022053-idft1p6d 466 47 Flu Flu NNP cord-022053-idft1p6d 466 48 ) ) -RRB- cord-022053-idft1p6d 466 49 a a DT cord-022053-idft1p6d 466 50 broad broad JJ cord-022053-idft1p6d 466 51 range range NN cord-022053-idft1p6d 466 52 of of IN cord-022053-idft1p6d 466 53 organisms organism NNS cord-022053-idft1p6d 466 54 and and CC cord-022053-idft1p6d 466 55 then then RB cord-022053-idft1p6d 466 56 detects detect VBZ cord-022053-idft1p6d 466 57 the the DT cord-022053-idft1p6d 466 58 PCR PCR NNP cord-022053-idft1p6d 466 59 products product NNS cord-022053-idft1p6d 466 60 through through IN cord-022053-idft1p6d 466 61 mass mass NN cord-022053-idft1p6d 466 62 spectroscopy spectroscopy NN cord-022053-idft1p6d 466 63 . . . cord-022053-idft1p6d 467 1 This this DT cord-022053-idft1p6d 467 2 approach approach NN cord-022053-idft1p6d 467 3 combines combine VBZ cord-022053-idft1p6d 467 4 amplification amplification NN cord-022053-idft1p6d 467 5 of of IN cord-022053-idft1p6d 467 6 many many JJ cord-022053-idft1p6d 467 7 sample sample NN cord-022053-idft1p6d 467 8 types type NNS cord-022053-idft1p6d 467 9 , , , cord-022053-idft1p6d 467 10 including include VBG cord-022053-idft1p6d 467 11 body body NN cord-022053-idft1p6d 467 12 fluids fluid NNS cord-022053-idft1p6d 467 13 , , , cord-022053-idft1p6d 467 14 tissue tissue NN cord-022053-idft1p6d 467 15 , , , cord-022053-idft1p6d 467 16 FFPE ffpe NN cord-022053-idft1p6d 467 17 , , , cord-022053-idft1p6d 467 18 culture culture NN cord-022053-idft1p6d 467 19 isolates isolate NNS cord-022053-idft1p6d 467 20 , , , cord-022053-idft1p6d 467 21 and and CC cord-022053-idft1p6d 467 22 blood blood NN cord-022053-idft1p6d 467 23 , , , cord-022053-idft1p6d 467 24 with with IN cord-022053-idft1p6d 467 25 a a DT cord-022053-idft1p6d 467 26 highly highly RB cord-022053-idft1p6d 467 27 sensitive sensitive JJ cord-022053-idft1p6d 467 28 detection detection NN cord-022053-idft1p6d 467 29 system system NN cord-022053-idft1p6d 467 30 to to TO cord-022053-idft1p6d 467 31 make make VB cord-022053-idft1p6d 467 32 subtle subtle JJ cord-022053-idft1p6d 467 33 species species NN cord-022053-idft1p6d 467 34 determinations determination NNS cord-022053-idft1p6d 467 35 across across IN cord-022053-idft1p6d 467 36 organism organism NN cord-022053-idft1p6d 467 37 types type NNS cord-022053-idft1p6d 467 38 , , , cord-022053-idft1p6d 467 39 including include VBG cord-022053-idft1p6d 467 40 bacterial bacterial JJ cord-022053-idft1p6d 467 41 , , , cord-022053-idft1p6d 467 42 fungal fungal JJ cord-022053-idft1p6d 467 43 , , , cord-022053-idft1p6d 467 44 viral viral JJ cord-022053-idft1p6d 467 45 , , , cord-022053-idft1p6d 467 46 and and CC cord-022053-idft1p6d 467 47 some some DT cord-022053-idft1p6d 467 48 parasitic parasitic JJ cord-022053-idft1p6d 467 49 . . . cord-022053-idft1p6d 468 1 [ [ -LRB- cord-022053-idft1p6d 468 2 167 167 CD cord-022053-idft1p6d 468 3 ] ] -RRB- cord-022053-idft1p6d 468 4 [ [ -LRB- cord-022053-idft1p6d 468 5 168 168 CD cord-022053-idft1p6d 468 6 ] ] -RRB- cord-022053-idft1p6d 468 7 [ [ -LRB- cord-022053-idft1p6d 468 8 169 169 CD cord-022053-idft1p6d 468 9 ] ] -RRB- cord-022053-idft1p6d 469 1 [ [ -LRB- cord-022053-idft1p6d 469 2 170 170 CD cord-022053-idft1p6d 469 3 ] ] -RRB- cord-022053-idft1p6d 470 1 As as IN cord-022053-idft1p6d 470 2 the the DT cord-022053-idft1p6d 470 3 database database NN cord-022053-idft1p6d 470 4 of of IN cord-022053-idft1p6d 470 5 spectra spectra NNP cord-022053-idft1p6d 470 6 improves improve VBZ cord-022053-idft1p6d 470 7 and and CC cord-022053-idft1p6d 470 8 the the DT cord-022053-idft1p6d 470 9 multiplex multiplex NN cord-022053-idft1p6d 470 10 primers primer NNS cord-022053-idft1p6d 470 11 improve improve VBP cord-022053-idft1p6d 470 12 , , , cord-022053-idft1p6d 470 13 this this DT cord-022053-idft1p6d 470 14 system system NN cord-022053-idft1p6d 470 15 will will MD cord-022053-idft1p6d 470 16 gain gain VB cord-022053-idft1p6d 470 17 popularity popularity NN cord-022053-idft1p6d 470 18 , , , cord-022053-idft1p6d 470 19 although although IN cord-022053-idft1p6d 470 20 it -PRON- PRP cord-022053-idft1p6d 470 21 is be VBZ cord-022053-idft1p6d 470 22 still still RB cord-022053-idft1p6d 470 23 limited limit VBN cord-022053-idft1p6d 470 24 by by IN cord-022053-idft1p6d 470 25 initial initial JJ cord-022053-idft1p6d 470 26 organism organism NN cord-022053-idft1p6d 470 27 burden burden NN cord-022053-idft1p6d 470 28 and and CC cord-022053-idft1p6d 470 29 procedure procedure NN cord-022053-idft1p6d 470 30 time time NN cord-022053-idft1p6d 470 31 ( ( -LRB- cord-022053-idft1p6d 470 32 up up IN cord-022053-idft1p6d 470 33 to to TO cord-022053-idft1p6d 470 34 8 8 CD cord-022053-idft1p6d 470 35 hours hour NNS cord-022053-idft1p6d 470 36 ) ) -RRB- cord-022053-idft1p6d 470 37 . . . cord-022053-idft1p6d 471 1 The the DT cord-022053-idft1p6d 471 2 microbiology microbiology NN cord-022053-idft1p6d 471 3 laboratory laboratory NN cord-022053-idft1p6d 471 4 remains remain VBZ cord-022053-idft1p6d 471 5 the the DT cord-022053-idft1p6d 471 6 most most RBS cord-022053-idft1p6d 471 7 important important JJ cord-022053-idft1p6d 471 8 companion companion NN cord-022053-idft1p6d 471 9 for for IN cord-022053-idft1p6d 471 10 anatomic anatomic JJ cord-022053-idft1p6d 471 11 pathologists pathologist NNS cord-022053-idft1p6d 471 12 who who WP cord-022053-idft1p6d 471 13 have have VBP cord-022053-idft1p6d 471 14 a a DT cord-022053-idft1p6d 471 15 potentially potentially RB cord-022053-idft1p6d 471 16 infectious infectious JJ cord-022053-idft1p6d 471 17 diagnosis diagnosis NN cord-022053-idft1p6d 471 18 under under IN cord-022053-idft1p6d 471 19 the the DT cord-022053-idft1p6d 471 20 microscope microscope NN cord-022053-idft1p6d 471 21 . . . cord-022053-idft1p6d 472 1 Anecdotal anecdotal JJ cord-022053-idft1p6d 472 2 and and CC cord-022053-idft1p6d 472 3 small small JJ cord-022053-idft1p6d 472 4 studies study NNS cord-022053-idft1p6d 472 5 have have VBP cord-022053-idft1p6d 472 6 demonstrated demonstrate VBN cord-022053-idft1p6d 472 7 that that IN cord-022053-idft1p6d 472 8 the the DT cord-022053-idft1p6d 472 9 yield yield NN cord-022053-idft1p6d 472 10 from from IN cord-022053-idft1p6d 472 11 molecular molecular JJ cord-022053-idft1p6d 472 12 tests test NNS cord-022053-idft1p6d 472 13 that that WDT cord-022053-idft1p6d 472 14 are be VBP cord-022053-idft1p6d 472 15 performed perform VBN cord-022053-idft1p6d 472 16 blindly blindly RB cord-022053-idft1p6d 472 17 ( ( -LRB- cord-022053-idft1p6d 472 18 without without IN cord-022053-idft1p6d 472 19 visualization visualization NN cord-022053-idft1p6d 472 20 ) ) -RRB- cord-022053-idft1p6d 472 21 versus versus IN cord-022053-idft1p6d 472 22 with with IN cord-022053-idft1p6d 472 23 pathologist pathologist NN cord-022053-idft1p6d 472 24 's 's POS cord-022053-idft1p6d 472 25 review review NN cord-022053-idft1p6d 472 26 is be VBZ cord-022053-idft1p6d 472 27 miniscule miniscule JJ cord-022053-idft1p6d 472 28 and and CC cord-022053-idft1p6d 472 29 extremely extremely RB cord-022053-idft1p6d 472 30 expensive expensive JJ cord-022053-idft1p6d 472 31 . . . cord-022053-idft1p6d 473 1 Therefore therefore RB cord-022053-idft1p6d 473 2 anatomic anatomic JJ cord-022053-idft1p6d 473 3 pathologists pathologist NNS cord-022053-idft1p6d 473 4 and and CC cord-022053-idft1p6d 473 5 their -PRON- PRP$ cord-022053-idft1p6d 473 6 microbiologic microbiologic JJ cord-022053-idft1p6d 473 7 colleagues colleague NNS cord-022053-idft1p6d 473 8 must must MD cord-022053-idft1p6d 473 9 have have VB cord-022053-idft1p6d 473 10 a a DT cord-022053-idft1p6d 473 11 constant constant JJ cord-022053-idft1p6d 473 12 line line NN cord-022053-idft1p6d 473 13 of of IN cord-022053-idft1p6d 473 14 communication communication NN cord-022053-idft1p6d 473 15 from from IN cord-022053-idft1p6d 473 16 the the DT cord-022053-idft1p6d 473 17 moment moment NN cord-022053-idft1p6d 473 18 the the DT cord-022053-idft1p6d 473 19 specimen specimen NN cord-022053-idft1p6d 473 20 is be VBZ cord-022053-idft1p6d 473 21 collected collect VBN cord-022053-idft1p6d 473 22 until until IN cord-022053-idft1p6d 473 23 final final JJ cord-022053-idft1p6d 473 24 reporting reporting NN cord-022053-idft1p6d 473 25 to to TO cord-022053-idft1p6d 473 26 ensure ensure VB cord-022053-idft1p6d 473 27 interpretation interpretation NN cord-022053-idft1p6d 473 28 of of IN cord-022053-idft1p6d 473 29 all all DT cord-022053-idft1p6d 473 30 modalities modality NNS cord-022053-idft1p6d 473 31 is be VBZ cord-022053-idft1p6d 473 32 maximally maximally RB cord-022053-idft1p6d 473 33 beneficial beneficial JJ cord-022053-idft1p6d 473 34 to to IN cord-022053-idft1p6d 473 35 patient patient JJ cord-022053-idft1p6d 473 36 care care NN cord-022053-idft1p6d 473 37 . . . cord-022053-idft1p6d 474 1 This this DT cord-022053-idft1p6d 474 2 dialogue dialogue NN cord-022053-idft1p6d 474 3 should should MD cord-022053-idft1p6d 474 4 also also RB cord-022053-idft1p6d 474 5 include include VB cord-022053-idft1p6d 474 6 discussions discussion NNS cord-022053-idft1p6d 474 7 of of IN cord-022053-idft1p6d 474 8 molecular molecular JJ cord-022053-idft1p6d 474 9 modalities modality NNS cord-022053-idft1p6d 474 10 that that WDT cord-022053-idft1p6d 474 11 are be VBP cord-022053-idft1p6d 474 12 applied apply VBN cord-022053-idft1p6d 474 13 to to IN cord-022053-idft1p6d 474 14 clinical clinical JJ cord-022053-idft1p6d 474 15 and and CC cord-022053-idft1p6d 474 16 anatomic anatomic JJ cord-022053-idft1p6d 474 17 pathology pathology NN cord-022053-idft1p6d 474 18 specimens specimen NNS cord-022053-idft1p6d 474 19 and and CC cord-022053-idft1p6d 474 20 changes change NNS cord-022053-idft1p6d 474 21 , , , cord-022053-idft1p6d 474 22 advantages advantage NNS cord-022053-idft1p6d 474 23 , , , cord-022053-idft1p6d 474 24 pitfalls pitfall NNS cord-022053-idft1p6d 474 25 , , , cord-022053-idft1p6d 474 26 and and CC cord-022053-idft1p6d 474 27 benefits benefit NNS cord-022053-idft1p6d 474 28 of of IN cord-022053-idft1p6d 474 29 those those DT cord-022053-idft1p6d 474 30 modalities modality NNS cord-022053-idft1p6d 474 31 in in IN cord-022053-idft1p6d 474 32 an an DT cord-022053-idft1p6d 474 33 ever ever RB cord-022053-idft1p6d 474 34 - - HYPH cord-022053-idft1p6d 474 35 evolving evolve VBG cord-022053-idft1p6d 474 36 manner manner NN cord-022053-idft1p6d 474 37 . . . cord-022053-idft1p6d 475 1 As as IN cord-022053-idft1p6d 475 2 with with IN cord-022053-idft1p6d 475 3 any any DT cord-022053-idft1p6d 475 4 approach approach NN cord-022053-idft1p6d 475 5 to to IN cord-022053-idft1p6d 475 6 medicine medicine NN cord-022053-idft1p6d 475 7 , , , cord-022053-idft1p6d 475 8 evidence evidence NN cord-022053-idft1p6d 475 9 - - HYPH cord-022053-idft1p6d 475 10 based base VBN cord-022053-idft1p6d 475 11 use use NN cord-022053-idft1p6d 475 12 of of IN cord-022053-idft1p6d 475 13 the the DT cord-022053-idft1p6d 475 14 most most RBS cord-022053-idft1p6d 475 15 efficient efficient JJ cord-022053-idft1p6d 475 16 and and CC cord-022053-idft1p6d 475 17 inexpensive inexpensive JJ cord-022053-idft1p6d 475 18 method method NN cord-022053-idft1p6d 475 19 that that WDT cord-022053-idft1p6d 475 20 produces produce VBZ cord-022053-idft1p6d 475 21 the the DT cord-022053-idft1p6d 475 22 highest high JJS cord-022053-idft1p6d 475 23 - - HYPH cord-022053-idft1p6d 475 24 impact impact NN cord-022053-idft1p6d 475 25 result result NN cord-022053-idft1p6d 475 26 for for IN cord-022053-idft1p6d 475 27 the the DT cord-022053-idft1p6d 475 28 patient patient NN cord-022053-idft1p6d 475 29 is be VBZ cord-022053-idft1p6d 475 30 the the DT cord-022053-idft1p6d 475 31 constant constant JJ cord-022053-idft1p6d 475 32 goal goal NN cord-022053-idft1p6d 475 33 . . . cord-022053-idft1p6d 476 1 MS MS NNP cord-022053-idft1p6d 476 2 technology technology NN cord-022053-idft1p6d 476 3 for for IN cord-022053-idft1p6d 476 4 microorganism microorganism NN cord-022053-idft1p6d 476 5 identification identification NN cord-022053-idft1p6d 476 6 in in IN cord-022053-idft1p6d 476 7 a a DT cord-022053-idft1p6d 476 8 public public JJ cord-022053-idft1p6d 476 9 health health NN cord-022053-idft1p6d 476 10 reference reference NN cord-022053-idft1p6d 476 11 laboratory laboratory NN cord-022053-idft1p6d 477 1 Ongoing ongoing JJ cord-022053-idft1p6d 477 2 revolution revolution NN cord-022053-idft1p6d 477 3 in in IN cord-022053-idft1p6d 477 4 bacteriology bacteriology NN cord-022053-idft1p6d 477 5 : : : cord-022053-idft1p6d 477 6 routine routine JJ cord-022053-idft1p6d 477 7 identification identification NN cord-022053-idft1p6d 477 8 of of IN cord-022053-idft1p6d 477 9 bacteria bacteria NNS cord-022053-idft1p6d 477 10 by by IN cord-022053-idft1p6d 477 11 matrix matrix NN cord-022053-idft1p6d 477 12 - - HYPH cord-022053-idft1p6d 477 13 assisted assist VBN cord-022053-idft1p6d 477 14 laser laser NN cord-022053-idft1p6d 477 15 desorption desorption NN cord-022053-idft1p6d 477 16 ionization ionization NN cord-022053-idft1p6d 477 17 time time NN cord-022053-idft1p6d 477 18 - - HYPH cord-022053-idft1p6d 477 19 of of IN cord-022053-idft1p6d 477 20 - - HYPH cord-022053-idft1p6d 477 21 flight flight NN cord-022053-idft1p6d 477 22 mass mass NN cord-022053-idft1p6d 477 23 spectrometry spectrometry NN cord-022053-idft1p6d 477 24 Bruker Bruker NNP cord-022053-idft1p6d 477 25 biotyper biotyper NN cord-022053-idft1p6d 477 26 matrix matrix NN cord-022053-idft1p6d 477 27 - - HYPH cord-022053-idft1p6d 477 28 assisted assist VBN cord-022053-idft1p6d 477 29 laser laser NN cord-022053-idft1p6d 477 30 desorption desorption NN cord-022053-idft1p6d 477 31 ionization ionization NN cord-022053-idft1p6d 477 32 - - HYPH cord-022053-idft1p6d 477 33 time time NN cord-022053-idft1p6d 477 34 of of IN cord-022053-idft1p6d 477 35 flight flight NN cord-022053-idft1p6d 477 36 mass mass NN cord-022053-idft1p6d 477 37 spectrometry spectrometry NN cord-022053-idft1p6d 477 38 system system NN cord-022053-idft1p6d 477 39 for for IN cord-022053-idft1p6d 477 40 identification identification NN cord-022053-idft1p6d 477 41 of of IN cord-022053-idft1p6d 477 42 Nocardia Nocardia NNP cord-022053-idft1p6d 477 43 , , , cord-022053-idft1p6d 477 44 Rhodococcus Rhodococcus NNP cord-022053-idft1p6d 477 45 , , , cord-022053-idft1p6d 477 46 Kocuria Kocuria NNP cord-022053-idft1p6d 477 47 , , , cord-022053-idft1p6d 477 48 Gordonia Gordonia NNP cord-022053-idft1p6d 477 49 , , , cord-022053-idft1p6d 477 50 Tsukamurella Tsukamurella NNP cord-022053-idft1p6d 477 51 , , , cord-022053-idft1p6d 477 52 and and CC cord-022053-idft1p6d 477 53 Listeria Listeria NNP cord-022053-idft1p6d 477 54 species specie VBZ cord-022053-idft1p6d 477 55 Evaluation Evaluation NNP cord-022053-idft1p6d 477 56 of of IN cord-022053-idft1p6d 477 57 the the DT cord-022053-idft1p6d 477 58 Bruker Bruker NNP cord-022053-idft1p6d 477 59 MALDI MALDI NNP cord-022053-idft1p6d 477 60 Biotyper Biotyper NNP cord-022053-idft1p6d 477 61 for for IN cord-022053-idft1p6d 477 62 identification identification NN cord-022053-idft1p6d 477 63 of of IN cord-022053-idft1p6d 477 64 Gram gram NN cord-022053-idft1p6d 477 65 - - HYPH cord-022053-idft1p6d 477 66 positive positive JJ cord-022053-idft1p6d 477 67 rods rod NNS cord-022053-idft1p6d 477 68 : : : cord-022053-idft1p6d 477 69 development development NN cord-022053-idft1p6d 477 70 of of IN cord-022053-idft1p6d 477 71 a a DT cord-022053-idft1p6d 477 72 diagnostic diagnostic JJ cord-022053-idft1p6d 477 73 algorithm algorithm NN cord-022053-idft1p6d 477 74 for for IN cord-022053-idft1p6d 477 75 the the DT cord-022053-idft1p6d 477 76 clinical clinical JJ cord-022053-idft1p6d 477 77 laboratory laboratory NN cord-022053-idft1p6d 478 1 Multicenter multicenter JJ cord-022053-idft1p6d 478 2 evaluation evaluation NN cord-022053-idft1p6d 478 3 of of IN cord-022053-idft1p6d 478 4 the the DT cord-022053-idft1p6d 478 5 Vitek Vitek NNP cord-022053-idft1p6d 478 6 MS MS NNP cord-022053-idft1p6d 478 7 matrix matrix NN cord-022053-idft1p6d 478 8 - - HYPH cord-022053-idft1p6d 478 9 assisted assist VBN cord-022053-idft1p6d 478 10 laser laser NN cord-022053-idft1p6d 478 11 desorption desorption NN cord-022053-idft1p6d 478 12 ionization ionization NN cord-022053-idft1p6d 478 13 - - HYPH cord-022053-idft1p6d 478 14 time time NN cord-022053-idft1p6d 478 15 of of IN cord-022053-idft1p6d 478 16 flight flight NN cord-022053-idft1p6d 478 17 mass mass NN cord-022053-idft1p6d 478 18 spectrometry spectrometry NN cord-022053-idft1p6d 478 19 system system NN cord-022053-idft1p6d 478 20 for for IN cord-022053-idft1p6d 478 21 identification identification NN cord-022053-idft1p6d 478 22 of of IN cord-022053-idft1p6d 478 23 Gram gram NN cord-022053-idft1p6d 478 24 - - HYPH cord-022053-idft1p6d 478 25 positive positive JJ cord-022053-idft1p6d 478 26 aerobic aerobic JJ cord-022053-idft1p6d 478 27 bacteria bacteria NNS cord-022053-idft1p6d 478 28 Kocuria Kocuria NNP cord-022053-idft1p6d 478 29 rhizophila rhizophila NN cord-022053-idft1p6d 478 30 misidentified misidentifie VBN cord-022053-idft1p6d 478 31 as as IN cord-022053-idft1p6d 478 32 Corynebacterium Corynebacterium NNP cord-022053-idft1p6d 478 33 jeikeium jeikeium NN cord-022053-idft1p6d 478 34 and and CC cord-022053-idft1p6d 478 35 other other JJ cord-022053-idft1p6d 478 36 errors error NNS cord-022053-idft1p6d 478 37 caused cause VBN cord-022053-idft1p6d 478 38 by by IN cord-022053-idft1p6d 478 39 the the DT cord-022053-idft1p6d 478 40 Vitek Vitek NNP cord-022053-idft1p6d 478 41 MS MS NNP cord-022053-idft1p6d 478 42 system system NN cord-022053-idft1p6d 478 43 call call NN cord-022053-idft1p6d 478 44 for for IN cord-022053-idft1p6d 478 45 maintained maintain VBN cord-022053-idft1p6d 478 46 microbiological microbiological JJ cord-022053-idft1p6d 478 47 competence competence NN cord-022053-idft1p6d 478 48 in in IN cord-022053-idft1p6d 478 49 the the DT cord-022053-idft1p6d 478 50 era era NN cord-022053-idft1p6d 478 51 of of IN cord-022053-idft1p6d 478 52 matrix matrix NN cord-022053-idft1p6d 478 53 - - HYPH cord-022053-idft1p6d 478 54 assisted assist VBN cord-022053-idft1p6d 478 55 laser laser NN cord-022053-idft1p6d 478 56 desorption desorption NN cord-022053-idft1p6d 478 57 ionization ionization NN cord-022053-idft1p6d 478 58 - - HYPH cord-022053-idft1p6d 478 59 time time NN cord-022053-idft1p6d 478 60 of of IN cord-022053-idft1p6d 478 61 flight flight NN cord-022053-idft1p6d 478 62 mass mass NN cord-022053-idft1p6d 478 63 spectrometry spectrometry NN cord-022053-idft1p6d 478 64 Importance importance NN cord-022053-idft1p6d 478 65 of of IN cord-022053-idft1p6d 478 66 using use VBG cord-022053-idft1p6d 478 67 Bruker Bruker NNP cord-022053-idft1p6d 478 68 's 's POS cord-022053-idft1p6d 478 69 securityrelevant securityrelevant JJ cord-022053-idft1p6d 478 70 library library NN cord-022053-idft1p6d 478 71 for for IN cord-022053-idft1p6d 478 72 Biotyper Biotyper NNP cord-022053-idft1p6d 478 73 identification identification NN cord-022053-idft1p6d 478 74 of of IN cord-022053-idft1p6d 478 75 Burkholderia Burkholderia NNP cord-022053-idft1p6d 478 76 pseudomallei pseudomallei NN cord-022053-idft1p6d 478 77 , , , cord-022053-idft1p6d 478 78 Brucella Brucella NNP cord-022053-idft1p6d 478 79 species specie NNS cord-022053-idft1p6d 478 80 , , , cord-022053-idft1p6d 478 81 and and CC cord-022053-idft1p6d 478 82 Francisella Francisella NNP cord-022053-idft1p6d 478 83 tularensis tularensis NNP cord-022053-idft1p6d 478 84 Matrix Matrix NNP cord-022053-idft1p6d 478 85 - - HYPH cord-022053-idft1p6d 478 86 assisted assist VBN cord-022053-idft1p6d 478 87 laser laser NN cord-022053-idft1p6d 478 88 desorption desorption NN cord-022053-idft1p6d 478 89 / / SYM cord-022053-idft1p6d 478 90 ionization ionization NN cord-022053-idft1p6d 478 91 time time NN cord-022053-idft1p6d 478 92 - - HYPH cord-022053-idft1p6d 478 93 of of IN cord-022053-idft1p6d 478 94 - - HYPH cord-022053-idft1p6d 478 95 flight flight NN cord-022053-idft1p6d 478 96 mass mass NN cord-022053-idft1p6d 478 97 spectrometry spectrometry NN cord-022053-idft1p6d 478 98 : : : cord-022053-idft1p6d 478 99 a a DT cord-022053-idft1p6d 478 100 new new JJ cord-022053-idft1p6d 478 101 possibility possibility NN cord-022053-idft1p6d 478 102 for for IN cord-022053-idft1p6d 478 103 the the DT cord-022053-idft1p6d 478 104 identification identification NN cord-022053-idft1p6d 478 105 and and CC cord-022053-idft1p6d 478 106 typing typing NN cord-022053-idft1p6d 478 107 of of IN cord-022053-idft1p6d 478 108 anaerobic anaerobic JJ cord-022053-idft1p6d 478 109 bacteria bacteria NNS cord-022053-idft1p6d 478 110 Multi multi JJ cord-022053-idft1p6d 478 111 - - JJ cord-022053-idft1p6d 478 112 centre centre JJ cord-022053-idft1p6d 478 113 evaluation evaluation NN cord-022053-idft1p6d 478 114 of of IN cord-022053-idft1p6d 478 115 mass mass JJ cord-022053-idft1p6d 478 116 spectrometric spectrometric JJ cord-022053-idft1p6d 478 117 identification identification NN cord-022053-idft1p6d 478 118 of of IN cord-022053-idft1p6d 478 119 anaerobic anaerobic JJ cord-022053-idft1p6d 478 120 bacteria bacteria NNS cord-022053-idft1p6d 478 121 using use VBG cord-022053-idft1p6d 478 122 the the DT cord-022053-idft1p6d 478 123 VITEK(R vitek(r NN cord-022053-idft1p6d 478 124 ) ) -RRB- cord-022053-idft1p6d 479 1 MS MS NNP cord-022053-idft1p6d 479 2 system system NN cord-022053-idft1p6d 479 3 Anaerobic anaerobic JJ cord-022053-idft1p6d 479 4 blood blood NN cord-022053-idft1p6d 479 5 culture culture NN cord-022053-idft1p6d 479 6 isolates isolate VBZ cord-022053-idft1p6d 479 7 in in IN cord-022053-idft1p6d 479 8 a a DT cord-022053-idft1p6d 479 9 Norwegian norwegian JJ cord-022053-idft1p6d 479 10 university university NN cord-022053-idft1p6d 479 11 hospital hospital NN cord-022053-idft1p6d 479 12 : : : cord-022053-idft1p6d 479 13 identification identification NN cord-022053-idft1p6d 479 14 by by IN cord-022053-idft1p6d 479 15 MALDI MALDI NNP cord-022053-idft1p6d 479 16 - - HYPH cord-022053-idft1p6d 479 17 TOF TOF NNP cord-022053-idft1p6d 479 18 MS MS NNP cord-022053-idft1p6d 479 19 vs vs IN cord-022053-idft1p6d 480 1 16S 16S NNP cord-022053-idft1p6d 480 2 rRNA rrna NN cord-022053-idft1p6d 480 3 sequencing sequencing NN cord-022053-idft1p6d 480 4 and and CC cord-022053-idft1p6d 480 5 antimicrobial antimicrobial JJ cord-022053-idft1p6d 480 6 susceptibility susceptibility NN cord-022053-idft1p6d 480 7 profiles profile NNS cord-022053-idft1p6d 480 8 ESCMID ESCMID NNP cord-022053-idft1p6d 480 9 Study Study NNP cord-022053-idft1p6d 480 10 Group Group NNP cord-022053-idft1p6d 480 11 on on IN cord-022053-idft1p6d 480 12 Antimicrobial Antimicrobial NNP cord-022053-idft1p6d 480 13 Resistance Resistance NNP cord-022053-idft1p6d 480 14 in in IN cord-022053-idft1p6d 480 15 Anaerobic Anaerobic NNP cord-022053-idft1p6d 480 16 Bacteria Bacteria NNS cord-022053-idft1p6d 480 17 . . . cord-022053-idft1p6d 481 1 Species specie NNS cord-022053-idft1p6d 481 2 identification identification NN cord-022053-idft1p6d 481 3 of of IN cord-022053-idft1p6d 481 4 clinical clinical JJ cord-022053-idft1p6d 481 5 isolates isolate NNS cord-022053-idft1p6d 481 6 of of IN cord-022053-idft1p6d 481 7 Bacteroides Bacteroides NNP cord-022053-idft1p6d 481 8 by by IN cord-022053-idft1p6d 481 9 matrixassisted matrixassiste VBN cord-022053-idft1p6d 481 10 laser laser NN cord-022053-idft1p6d 481 11 - - HYPH cord-022053-idft1p6d 481 12 desorption desorption NN cord-022053-idft1p6d 481 13 / / SYM cord-022053-idft1p6d 481 14 ionization ionization NN cord-022053-idft1p6d 481 15 time time NN cord-022053-idft1p6d 481 16 - - HYPH cord-022053-idft1p6d 481 17 of of IN cord-022053-idft1p6d 481 18 - - HYPH cord-022053-idft1p6d 481 19 flight flight NN cord-022053-idft1p6d 481 20 mass mass NN cord-022053-idft1p6d 481 21 spectrometry spectrometry NN cord-022053-idft1p6d 481 22 Performance performance NN cord-022053-idft1p6d 481 23 of of IN cord-022053-idft1p6d 481 24 MALDI MALDI NNP cord-022053-idft1p6d 481 25 - - HYPH cord-022053-idft1p6d 481 26 TOF TOF NNP cord-022053-idft1p6d 481 27 MS MS NNP cord-022053-idft1p6d 481 28 platforms platform NNS cord-022053-idft1p6d 481 29 for for IN cord-022053-idft1p6d 481 30 fungal fungal JJ cord-022053-idft1p6d 481 31 identification identification NN cord-022053-idft1p6d 481 32 MALDI MALDI NNP cord-022053-idft1p6d 481 33 - - HYPH cord-022053-idft1p6d 481 34 TOF TOF NNP cord-022053-idft1p6d 481 35 mass mass NN cord-022053-idft1p6d 481 36 spectrometry spectrometry NN cord-022053-idft1p6d 481 37 proteomic proteomic NN cord-022053-idft1p6d 481 38 phenotyping phenotyping NN cord-022053-idft1p6d 481 39 of of IN cord-022053-idft1p6d 481 40 clinically clinically RB cord-022053-idft1p6d 481 41 relevant relevant JJ cord-022053-idft1p6d 481 42 fungi fungus NNS cord-022053-idft1p6d 481 43 Improved improve VBD cord-022053-idft1p6d 481 44 clinical clinical JJ cord-022053-idft1p6d 481 45 laboratory laboratory NN cord-022053-idft1p6d 481 46 identification identification NN cord-022053-idft1p6d 481 47 of of IN cord-022053-idft1p6d 481 48 human human JJ cord-022053-idft1p6d 481 49 pathogenic pathogenic JJ cord-022053-idft1p6d 481 50 yeasts yeast NNS cord-022053-idft1p6d 481 51 by by IN cord-022053-idft1p6d 481 52 matrix matrix NN cord-022053-idft1p6d 481 53 - - HYPH cord-022053-idft1p6d 481 54 assisted assist VBN cord-022053-idft1p6d 481 55 laser laser NN cord-022053-idft1p6d 481 56 desorption desorption NN cord-022053-idft1p6d 481 57 ionization ionization NN cord-022053-idft1p6d 481 58 time time NN cord-022053-idft1p6d 481 59 - - HYPH cord-022053-idft1p6d 481 60 offlight offlight VBN cord-022053-idft1p6d 481 61 mass mass NN cord-022053-idft1p6d 481 62 spectrometry spectrometry NN cord-022053-idft1p6d 481 63 Comparison comparison NN cord-022053-idft1p6d 481 64 of of IN cord-022053-idft1p6d 481 65 the the DT cord-022053-idft1p6d 481 66 accuracy accuracy NN cord-022053-idft1p6d 481 67 of of IN cord-022053-idft1p6d 481 68 two two CD cord-022053-idft1p6d 481 69 conventional conventional JJ cord-022053-idft1p6d 481 70 phenotypic phenotypic JJ cord-022053-idft1p6d 481 71 methods method NNS cord-022053-idft1p6d 481 72 and and CC cord-022053-idft1p6d 481 73 two two CD cord-022053-idft1p6d 481 74 MALDI MALDI NNS cord-022053-idft1p6d 481 75 - - HYPH cord-022053-idft1p6d 481 76 TOF TOF NNP cord-022053-idft1p6d 481 77 MS MS NNP cord-022053-idft1p6d 481 78 systems system NNS cord-022053-idft1p6d 481 79 with with IN cord-022053-idft1p6d 481 80 that that DT cord-022053-idft1p6d 481 81 of of IN cord-022053-idft1p6d 481 82 DNA dna NN cord-022053-idft1p6d 481 83 sequencing sequencing NN cord-022053-idft1p6d 481 84 analysis analysis NN cord-022053-idft1p6d 481 85 for for IN cord-022053-idft1p6d 481 86 correctly correctly RB cord-022053-idft1p6d 481 87 identifying identify VBG cord-022053-idft1p6d 481 88 clinically clinically RB cord-022053-idft1p6d 481 89 encountered encounter VBN cord-022053-idft1p6d 481 90 yeasts yeast NNS cord-022053-idft1p6d 481 91 Comparative comparative JJ cord-022053-idft1p6d 481 92 evaluation evaluation NN cord-022053-idft1p6d 481 93 of of IN cord-022053-idft1p6d 481 94 the the DT cord-022053-idft1p6d 481 95 Bruker Bruker NNP cord-022053-idft1p6d 481 96 Biotyper Biotyper NNP cord-022053-idft1p6d 481 97 and and CC cord-022053-idft1p6d 481 98 Vitek Vitek NNP cord-022053-idft1p6d 481 99 MS MS NNP cord-022053-idft1p6d 481 100 matrix matrix NN cord-022053-idft1p6d 481 101 - - HYPH cord-022053-idft1p6d 481 102 assisted assist VBN cord-022053-idft1p6d 481 103 laser laser NN cord-022053-idft1p6d 481 104 desorption desorption NN cord-022053-idft1p6d 481 105 ionization ionization NN cord-022053-idft1p6d 481 106 - - HYPH cord-022053-idft1p6d 481 107 time time NN cord-022053-idft1p6d 481 108 of of IN cord-022053-idft1p6d 481 109 flight flight NN cord-022053-idft1p6d 481 110 ( ( -LRB- cord-022053-idft1p6d 481 111 MALDI MALDI NNP cord-022053-idft1p6d 481 112 - - HYPH cord-022053-idft1p6d 481 113 TOF TOF NNP cord-022053-idft1p6d 481 114 ) ) -RRB- cord-022053-idft1p6d 481 115 mass mass NN cord-022053-idft1p6d 481 116 spectrometry spectrometry NN cord-022053-idft1p6d 481 117 systems system NNS cord-022053-idft1p6d 481 118 for for IN cord-022053-idft1p6d 481 119 identification identification NN cord-022053-idft1p6d 481 120 of of IN cord-022053-idft1p6d 481 121 yeasts yeast NNS cord-022053-idft1p6d 481 122 of of IN cord-022053-idft1p6d 481 123 medical medical JJ cord-022053-idft1p6d 481 124 importance importance NN cord-022053-idft1p6d 482 1 Interlaboratory interlaboratory JJ cord-022053-idft1p6d 482 2 comparison comparison NN cord-022053-idft1p6d 482 3 of of IN cord-022053-idft1p6d 482 4 sample sample NN cord-022053-idft1p6d 482 5 preparation preparation NN cord-022053-idft1p6d 482 6 methods method NNS cord-022053-idft1p6d 482 7 , , , cord-022053-idft1p6d 482 8 database database NN cord-022053-idft1p6d 482 9 expansions expansion NNS cord-022053-idft1p6d 482 10 , , , cord-022053-idft1p6d 482 11 and and CC cord-022053-idft1p6d 482 12 cutoff cutoff NN cord-022053-idft1p6d 482 13 values value NNS cord-022053-idft1p6d 482 14 for for IN cord-022053-idft1p6d 482 15 identification identification NN cord-022053-idft1p6d 482 16 of of IN cord-022053-idft1p6d 482 17 yeasts yeast NNS cord-022053-idft1p6d 482 18 by by IN cord-022053-idft1p6d 482 19 matrix matrix NN cord-022053-idft1p6d 482 20 - - HYPH cord-022053-idft1p6d 482 21 assisted assist VBN cord-022053-idft1p6d 482 22 laser laser NN cord-022053-idft1p6d 482 23 desorption desorption NN cord-022053-idft1p6d 482 24 ionization ionization NN cord-022053-idft1p6d 482 25 - - HYPH cord-022053-idft1p6d 482 26 time time NN cord-022053-idft1p6d 482 27 of of IN cord-022053-idft1p6d 482 28 flight flight NN cord-022053-idft1p6d 482 29 mass mass NN cord-022053-idft1p6d 482 30 spectrometry spectrometry NN cord-022053-idft1p6d 482 31 using use VBG cord-022053-idft1p6d 482 32 a a DT cord-022053-idft1p6d 482 33 yeast yeast NN cord-022053-idft1p6d 482 34 test test NN cord-022053-idft1p6d 482 35 panel panel NN cord-022053-idft1p6d 482 36 Clinical clinical JJ cord-022053-idft1p6d 482 37 performance performance NN cord-022053-idft1p6d 482 38 evaluation evaluation NN cord-022053-idft1p6d 482 39 of of IN cord-022053-idft1p6d 482 40 the the DT cord-022053-idft1p6d 482 41 Sofia Sofia NNP cord-022053-idft1p6d 482 42 RSV RSV NNP cord-022053-idft1p6d 482 43 FIA FIA NNP cord-022053-idft1p6d 482 44 rapid rapid JJ cord-022053-idft1p6d 482 45 antigen antigen NN cord-022053-idft1p6d 482 46 test test NN cord-022053-idft1p6d 482 47 for for IN cord-022053-idft1p6d 482 48 diagnosis diagnosis NN cord-022053-idft1p6d 482 49 of of IN cord-022053-idft1p6d 482 50 respiratory respiratory JJ cord-022053-idft1p6d 482 51 syncytial syncytial JJ cord-022053-idft1p6d 482 52 virus virus NN cord-022053-idft1p6d 482 53 infection infection NN cord-022053-idft1p6d 482 54 Serological serological JJ cord-022053-idft1p6d 482 55 markers marker NNS cord-022053-idft1p6d 482 56 in in IN cord-022053-idft1p6d 482 57 early early JJ cord-022053-idft1p6d 482 58 stages stage NNS cord-022053-idft1p6d 482 59 of of IN cord-022053-idft1p6d 482 60 human human JJ cord-022053-idft1p6d 482 61 immunodeficiency immunodeficiency NN cord-022053-idft1p6d 482 62 virus virus NN cord-022053-idft1p6d 482 63 infection infection NN cord-022053-idft1p6d 482 64 in in IN cord-022053-idft1p6d 482 65 haemophiliacs haemophiliacs NNP cord-022053-idft1p6d 482 66 Matrix Matrix NNP cord-022053-idft1p6d 482 67 - - HYPH cord-022053-idft1p6d 482 68 assisted assist VBN cord-022053-idft1p6d 482 69 laser laser NN cord-022053-idft1p6d 482 70 desorption desorption NN cord-022053-idft1p6d 482 71 ionization ionization NN cord-022053-idft1p6d 482 72 - - HYPH cord-022053-idft1p6d 482 73 time time NN cord-022053-idft1p6d 482 74 of of IN cord-022053-idft1p6d 482 75 flight flight NN cord-022053-idft1p6d 482 76 mass mass NN cord-022053-idft1p6d 482 77 spectrometry spectrometry NN cord-022053-idft1p6d 482 78 : : : cord-022053-idft1p6d 482 79 a a DT cord-022053-idft1p6d 482 80 fundamental fundamental JJ cord-022053-idft1p6d 482 81 shift shift NN cord-022053-idft1p6d 482 82 in in IN cord-022053-idft1p6d 482 83 the the DT cord-022053-idft1p6d 482 84 routine routine JJ cord-022053-idft1p6d 482 85 practice practice NN cord-022053-idft1p6d 482 86 of of IN cord-022053-idft1p6d 482 87 clinical clinical JJ cord-022053-idft1p6d 482 88 microbiology microbiology NN cord-022053-idft1p6d 482 89 Matrix Matrix NNP cord-022053-idft1p6d 482 90 - - HYPH cord-022053-idft1p6d 482 91 assisted assist VBN cord-022053-idft1p6d 482 92 laser laser NN cord-022053-idft1p6d 482 93 desorption desorption NN cord-022053-idft1p6d 482 94 ionization ionization NN cord-022053-idft1p6d 482 95 - - HYPH cord-022053-idft1p6d 482 96 time time NN cord-022053-idft1p6d 482 97 of of IN cord-022053-idft1p6d 482 98 flight flight NN cord-022053-idft1p6d 482 99 mass mass NN cord-022053-idft1p6d 482 100 spectrometry spectrometry NN cord-022053-idft1p6d 482 101 in in IN cord-022053-idft1p6d 482 102 clinical clinical JJ cord-022053-idft1p6d 482 103 microbiology microbiology NN cord-022053-idft1p6d 482 104 MS MS NNP cord-022053-idft1p6d 482 105 for for IN cord-022053-idft1p6d 482 106 the the DT cord-022053-idft1p6d 482 107 diagnosis diagnosis NN cord-022053-idft1p6d 482 108 of of IN cord-022053-idft1p6d 482 109 infectious infectious JJ cord-022053-idft1p6d 482 110 diseases disease NNS cord-022053-idft1p6d 483 1 A a DT cord-022053-idft1p6d 483 2 side side NN cord-022053-idft1p6d 483 3 by by IN cord-022053-idft1p6d 483 4 side side JJ cord-022053-idft1p6d 483 5 comparison comparison NN cord-022053-idft1p6d 483 6 of of IN cord-022053-idft1p6d 483 7 Bruker Bruker NNP cord-022053-idft1p6d 483 8 Biotyper Biotyper NNP cord-022053-idft1p6d 483 9 and and CC cord-022053-idft1p6d 483 10 VITEK VITEK NNP cord-022053-idft1p6d 483 11 MS MS NNP cord-022053-idft1p6d 483 12 : : : cord-022053-idft1p6d 483 13 utility utility NN cord-022053-idft1p6d 483 14 of of IN cord-022053-idft1p6d 483 15 screening screening NN cord-022053-idft1p6d 483 16 methods method NNS cord-022053-idft1p6d 483 17 and and CC cord-022053-idft1p6d 483 18 matrix matrix NN cord-022053-idft1p6d 483 19 - - HYPH cord-022053-idft1p6d 483 20 assisted assist VBN cord-022053-idft1p6d 483 21 laser laser NN cord-022053-idft1p6d 483 22 desorption desorption NN cord-022053-idft1p6d 483 23 ionizationtime ionizationtime NN cord-022053-idft1p6d 483 24 of of IN cord-022053-idft1p6d 483 25 flight flight NN cord-022053-idft1p6d 483 26 mass mass NN cord-022053-idft1p6d 483 27 spectrometry spectrometry NN cord-022053-idft1p6d 483 28 Direct direct JJ cord-022053-idft1p6d 483 29 identification identification NN cord-022053-idft1p6d 483 30 of of IN cord-022053-idft1p6d 483 31 urinary urinary JJ cord-022053-idft1p6d 483 32 tract tract NN cord-022053-idft1p6d 483 33 pathogens pathogen NNS cord-022053-idft1p6d 483 34 from from IN cord-022053-idft1p6d 483 35 urine urine NN cord-022053-idft1p6d 483 36 samples sample NNS cord-022053-idft1p6d 483 37 using use VBG cord-022053-idft1p6d 483 38 the the DT cord-022053-idft1p6d 483 39 Vitek Vitek NNP cord-022053-idft1p6d 483 40 MS MS NNP cord-022053-idft1p6d 483 41 system system NN cord-022053-idft1p6d 483 42 based base VBN cord-022053-idft1p6d 483 43 on on IN cord-022053-idft1p6d 483 44 matrix matrix NN cord-022053-idft1p6d 483 45 - - HYPH cord-022053-idft1p6d 483 46 assisted assist VBN cord-022053-idft1p6d 483 47 laser laser NN cord-022053-idft1p6d 483 48 desorption desorption NN cord-022053-idft1p6d 483 49 ionization ionization NN cord-022053-idft1p6d 483 50 - - HYPH cord-022053-idft1p6d 483 51 time time NN cord-022053-idft1p6d 483 52 of of IN cord-022053-idft1p6d 483 53 flight flight NN cord-022053-idft1p6d 483 54 mass mass NN cord-022053-idft1p6d 483 55 spectrometry spectrometry NN cord-022053-idft1p6d 483 56 Mass mass NN cord-022053-idft1p6d 483 57 spectrometry spectrometry NN cord-022053-idft1p6d 483 58 : : : cord-022053-idft1p6d 483 59 pneumococcal pneumococcal JJ cord-022053-idft1p6d 483 60 meningitis meningitis NN cord-022053-idft1p6d 483 61 verified verify VBN cord-022053-idft1p6d 483 62 and and CC cord-022053-idft1p6d 483 63 Brucella Brucella NNP cord-022053-idft1p6d 483 64 species specie NNS cord-022053-idft1p6d 483 65 identified identify VBN cord-022053-idft1p6d 483 66 in in IN cord-022053-idft1p6d 483 67 less less JJR cord-022053-idft1p6d 483 68 than than IN cord-022053-idft1p6d 483 69 half half PDT cord-022053-idft1p6d 483 70 an an DT cord-022053-idft1p6d 483 71 hour hour NN cord-022053-idft1p6d 483 72 Direct direct JJ cord-022053-idft1p6d 483 73 application application NN cord-022053-idft1p6d 483 74 of of IN cord-022053-idft1p6d 483 75 MALDI MALDI NNP cord-022053-idft1p6d 483 76 - - HYPH cord-022053-idft1p6d 483 77 TOF TOF NNP cord-022053-idft1p6d 483 78 mass mass NN cord-022053-idft1p6d 483 79 spectrometry spectrometry NN cord-022053-idft1p6d 483 80 to to IN cord-022053-idft1p6d 483 81 cerebrospinal cerebrospinal JJ cord-022053-idft1p6d 483 82 fluid fluid NN cord-022053-idft1p6d 483 83 for for IN cord-022053-idft1p6d 483 84 rapid rapid JJ cord-022053-idft1p6d 483 85 pathogen pathogen NN cord-022053-idft1p6d 483 86 identification identification NN cord-022053-idft1p6d 483 87 in in IN cord-022053-idft1p6d 483 88 a a DT cord-022053-idft1p6d 483 89 patient patient NN cord-022053-idft1p6d 483 90 with with IN cord-022053-idft1p6d 483 91 bacterial bacterial JJ cord-022053-idft1p6d 483 92 meningitis meningitis NN cord-022053-idft1p6d 483 93 Sample sample NN cord-022053-idft1p6d 483 94 preparation preparation NN cord-022053-idft1p6d 483 95 for for IN cord-022053-idft1p6d 483 96 mass mass JJ cord-022053-idft1p6d 483 97 spectrometry spectrometry NN cord-022053-idft1p6d 483 98 analysis analysis NN cord-022053-idft1p6d 483 99 of of IN cord-022053-idft1p6d 483 100 formalin formalin NN cord-022053-idft1p6d 483 101 - - HYPH cord-022053-idft1p6d 483 102 fixed fix VBN cord-022053-idft1p6d 483 103 paraffin paraffin NN cord-022053-idft1p6d 483 104 - - HYPH cord-022053-idft1p6d 483 105 embedded embed VBN cord-022053-idft1p6d 483 106 tissue tissue NN cord-022053-idft1p6d 483 107 : : : cord-022053-idft1p6d 483 108 proteomic proteomic JJ cord-022053-idft1p6d 483 109 analysis analysis NN cord-022053-idft1p6d 483 110 of of IN cord-022053-idft1p6d 483 111 formalin formalin NN cord-022053-idft1p6d 483 112 - - HYPH cord-022053-idft1p6d 483 113 fixed fix VBN cord-022053-idft1p6d 483 114 tissue tissue NN cord-022053-idft1p6d 483 115 Urinary urinary JJ cord-022053-idft1p6d 483 116 pellet pellet NN cord-022053-idft1p6d 483 117 sample sample NN cord-022053-idft1p6d 483 118 preparation preparation NN cord-022053-idft1p6d 483 119 for for IN cord-022053-idft1p6d 483 120 shotgun shotgun NN cord-022053-idft1p6d 483 121 proteomic proteomic JJ cord-022053-idft1p6d 483 122 analysis analysis NN cord-022053-idft1p6d 483 123 of of IN cord-022053-idft1p6d 483 124 microbial microbial JJ cord-022053-idft1p6d 483 125 infection infection NN cord-022053-idft1p6d 483 126 and and CC cord-022053-idft1p6d 484 1 host host NN cord-022053-idft1p6d 484 2 - - HYPH cord-022053-idft1p6d 484 3 pathogen pathogen NN cord-022053-idft1p6d 484 4 interactions interaction NNS cord-022053-idft1p6d 484 5 PNA PNA NNP cord-022053-idft1p6d 484 6 for for IN cord-022053-idft1p6d 484 7 rapid rapid JJ cord-022053-idft1p6d 484 8 microbiology microbiology NN cord-022053-idft1p6d 484 9 Peptide Peptide NNP cord-022053-idft1p6d 484 10 nucleic nucleic JJ cord-022053-idft1p6d 484 11 acid acid NN cord-022053-idft1p6d 484 12 fluorescence fluorescence NN cord-022053-idft1p6d 484 13 in in IN cord-022053-idft1p6d 484 14 situ situ JJ cord-022053-idft1p6d 484 15 hybridization hybridization NN cord-022053-idft1p6d 484 16 for for IN cord-022053-idft1p6d 484 17 rapid rapid JJ cord-022053-idft1p6d 484 18 detection detection NN cord-022053-idft1p6d 484 19 of of IN cord-022053-idft1p6d 484 20 Klebsiella Klebsiella NNP cord-022053-idft1p6d 484 21 pneumoniae pneumoniae NN cord-022053-idft1p6d 484 22 from from IN cord-022053-idft1p6d 484 23 positive positive JJ cord-022053-idft1p6d 484 24 blood blood NN cord-022053-idft1p6d 484 25 cultures culture NNS cord-022053-idft1p6d 484 26 Direct direct JJ cord-022053-idft1p6d 484 27 identification identification NN cord-022053-idft1p6d 484 28 of of IN cord-022053-idft1p6d 484 29 major major JJ cord-022053-idft1p6d 484 30 blood blood NN cord-022053-idft1p6d 484 31 culture culture NN cord-022053-idft1p6d 484 32 pathogens pathogen NNS cord-022053-idft1p6d 484 33 , , , cord-022053-idft1p6d 484 34 including include VBG cord-022053-idft1p6d 484 35 Pseudomonas Pseudomonas NNP cord-022053-idft1p6d 484 36 aeruginosa aeruginosa NN cord-022053-idft1p6d 484 37 and and CC cord-022053-idft1p6d 484 38 Escherichia Escherichia NNP cord-022053-idft1p6d 484 39 coli coli NNS cord-022053-idft1p6d 484 40 , , , cord-022053-idft1p6d 484 41 by by IN cord-022053-idft1p6d 484 42 a a DT cord-022053-idft1p6d 484 43 panel panel NN cord-022053-idft1p6d 484 44 of of IN cord-022053-idft1p6d 484 45 fluorescence fluorescence NN cord-022053-idft1p6d 484 46 in in IN cord-022053-idft1p6d 484 47 situ situ NN cord-022053-idft1p6d 484 48 hybridization hybridization NN cord-022053-idft1p6d 484 49 assays assay NNS cord-022053-idft1p6d 484 50 using use VBG cord-022053-idft1p6d 484 51 peptide peptide JJ cord-022053-idft1p6d 484 52 nucleic nucleic JJ cord-022053-idft1p6d 484 53 acid acid NN cord-022053-idft1p6d 484 54 probes probe NNS cord-022053-idft1p6d 484 55 Rapid rapid JJ cord-022053-idft1p6d 484 56 identification identification NN cord-022053-idft1p6d 484 57 of of IN cord-022053-idft1p6d 484 58 Staphylococcus Staphylococcus NNP cord-022053-idft1p6d 484 59 aureus aureu NNS cord-022053-idft1p6d 484 60 directly directly RB cord-022053-idft1p6d 484 61 from from IN cord-022053-idft1p6d 484 62 blood blood NN cord-022053-idft1p6d 484 63 cultures culture NNS cord-022053-idft1p6d 484 64 by by IN cord-022053-idft1p6d 484 65 fluorescence fluorescence NN cord-022053-idft1p6d 484 66 in in IN cord-022053-idft1p6d 484 67 situ situ NN cord-022053-idft1p6d 484 68 hybridization hybridization NN cord-022053-idft1p6d 484 69 with with IN cord-022053-idft1p6d 484 70 peptide peptide JJ cord-022053-idft1p6d 484 71 nucleic nucleic JJ cord-022053-idft1p6d 484 72 acid acid NN cord-022053-idft1p6d 484 73 probes probe NNS cord-022053-idft1p6d 484 74 Rapid rapid JJ cord-022053-idft1p6d 484 75 detection detection NN cord-022053-idft1p6d 484 76 of of IN cord-022053-idft1p6d 484 77 Enterococcus Enterococcus NNP cord-022053-idft1p6d 484 78 spp spp NNS cord-022053-idft1p6d 484 79 . . . cord-022053-idft1p6d 485 1 direct direct RB cord-022053-idft1p6d 485 2 from from IN cord-022053-idft1p6d 485 3 blood blood NN cord-022053-idft1p6d 485 4 culture culture NN cord-022053-idft1p6d 485 5 bottles bottle NNS cord-022053-idft1p6d 485 6 using use VBG cord-022053-idft1p6d 485 7 Enterococcus Enterococcus NNP cord-022053-idft1p6d 485 8 QuickFISH QuickFISH NNP cord-022053-idft1p6d 485 9 method method NN cord-022053-idft1p6d 485 10 : : : cord-022053-idft1p6d 485 11 a a DT cord-022053-idft1p6d 485 12 multicenter multicenter JJ cord-022053-idft1p6d 485 13 investigation investigation NN cord-022053-idft1p6d 485 14 Development Development NNP cord-022053-idft1p6d 485 15 of of IN cord-022053-idft1p6d 485 16 a a DT cord-022053-idft1p6d 485 17 peptide peptide NN cord-022053-idft1p6d 485 18 nucleic nucleic JJ cord-022053-idft1p6d 485 19 acid acid NN cord-022053-idft1p6d 485 20 probe probe NN cord-022053-idft1p6d 485 21 to to IN cord-022053-idft1p6d 485 22 Trichosporon Trichosporon NNP cord-022053-idft1p6d 485 23 species specie NNS cord-022053-idft1p6d 485 24 and and CC cord-022053-idft1p6d 485 25 identification identification NN cord-022053-idft1p6d 485 26 of of IN cord-022053-idft1p6d 485 27 trichosporonosis trichosporonosis NNP cord-022053-idft1p6d 485 28 by by IN cord-022053-idft1p6d 485 29 use use NN cord-022053-idft1p6d 485 30 of of IN cord-022053-idft1p6d 485 31 in in IN cord-022053-idft1p6d 485 32 situ situ NN cord-022053-idft1p6d 485 33 hybridization hybridization NN cord-022053-idft1p6d 485 34 in in IN cord-022053-idft1p6d 485 35 formalin formalin NN cord-022053-idft1p6d 485 36 - - HYPH cord-022053-idft1p6d 485 37 fixed fix VBN cord-022053-idft1p6d 485 38 and and CC cord-022053-idft1p6d 485 39 paraffin paraffin NN cord-022053-idft1p6d 485 40 - - HYPH cord-022053-idft1p6d 485 41 embedded embed VBN cord-022053-idft1p6d 485 42 ( ( -LRB- cord-022053-idft1p6d 485 43 FFPE FFPE NNP cord-022053-idft1p6d 485 44 ) ) -RRB- cord-022053-idft1p6d 485 45 sections section NNS cord-022053-idft1p6d 485 46 Design design NN cord-022053-idft1p6d 485 47 and and CC cord-022053-idft1p6d 485 48 evaluation evaluation NN cord-022053-idft1p6d 485 49 of of IN cord-022053-idft1p6d 485 50 peptide peptide JJ cord-022053-idft1p6d 485 51 nucleic nucleic JJ cord-022053-idft1p6d 485 52 acid acid NN cord-022053-idft1p6d 485 53 probes probe NNS cord-022053-idft1p6d 485 54 for for IN cord-022053-idft1p6d 485 55 specific specific JJ cord-022053-idft1p6d 485 56 identification identification NN cord-022053-idft1p6d 485 57 of of IN cord-022053-idft1p6d 485 58 Candida Candida NNP cord-022053-idft1p6d 485 59 albicans albican NNS cord-022053-idft1p6d 485 60 Identification identification NN cord-022053-idft1p6d 485 61 of of IN cord-022053-idft1p6d 485 62 Mycobacterium Mycobacterium NNP cord-022053-idft1p6d 485 63 species specie NNS cord-022053-idft1p6d 485 64 from from IN cord-022053-idft1p6d 485 65 BACTEC BACTEC NNP cord-022053-idft1p6d 485 66 MGIT MGIT NNP cord-022053-idft1p6d 485 67 positive positive JJ cord-022053-idft1p6d 485 68 cultures culture NNS cord-022053-idft1p6d 485 69 with with IN cord-022053-idft1p6d 485 70 Oligo Oligo NNP cord-022053-idft1p6d 485 71 - - HYPH cord-022053-idft1p6d 485 72 FISH FISH NNP cord-022053-idft1p6d 485 73 and and CC cord-022053-idft1p6d 485 74 PNA PNA NNP cord-022053-idft1p6d 485 75 - - HYPH cord-022053-idft1p6d 485 76 FISH fish NN cord-022053-idft1p6d 485 77 methods method NNS cord-022053-idft1p6d 485 78 Development development NN cord-022053-idft1p6d 485 79 and and CC cord-022053-idft1p6d 485 80 evaluation evaluation NN cord-022053-idft1p6d 485 81 of of IN cord-022053-idft1p6d 485 82 nucleic nucleic JJ cord-022053-idft1p6d 485 83 acid acid NN cord-022053-idft1p6d 485 84 - - HYPH cord-022053-idft1p6d 485 85 based base VBN cord-022053-idft1p6d 485 86 techniques technique NNS cord-022053-idft1p6d 485 87 for for IN cord-022053-idft1p6d 485 88 an an DT cord-022053-idft1p6d 485 89 auxiliary auxiliary JJ cord-022053-idft1p6d 485 90 diagnosis diagnosis NN cord-022053-idft1p6d 485 91 of of IN cord-022053-idft1p6d 485 92 invasive invasive JJ cord-022053-idft1p6d 485 93 fungal fungal JJ cord-022053-idft1p6d 485 94 infections infection NNS cord-022053-idft1p6d 485 95 in in IN cord-022053-idft1p6d 485 96 formalin formalin NN cord-022053-idft1p6d 485 97 - - HYPH cord-022053-idft1p6d 485 98 fixed fix VBN cord-022053-idft1p6d 485 99 and and CC cord-022053-idft1p6d 485 100 paraffin paraffin NN cord-022053-idft1p6d 485 101 - - HYPH cord-022053-idft1p6d 485 102 embedded embed VBN cord-022053-idft1p6d 485 103 ( ( -LRB- cord-022053-idft1p6d 485 104 FFPE FFPE NNP cord-022053-idft1p6d 485 105 ) ) -RRB- cord-022053-idft1p6d 485 106 tissues tissue VBZ cord-022053-idft1p6d 485 107 Comparison comparison NN cord-022053-idft1p6d 485 108 of of IN cord-022053-idft1p6d 485 109 quantitative quantitative JJ cord-022053-idft1p6d 485 110 real real JJ cord-022053-idft1p6d 485 111 time time NN cord-022053-idft1p6d 485 112 PCR PCR NNP cord-022053-idft1p6d 485 113 with with IN cord-022053-idft1p6d 485 114 sequencing sequencing NN cord-022053-idft1p6d 485 115 and and CC cord-022053-idft1p6d 485 116 ribosomal ribosomal JJ cord-022053-idft1p6d 485 117 RNA rna NN cord-022053-idft1p6d 485 118 - - HYPH cord-022053-idft1p6d 485 119 FISH FISH NNP cord-022053-idft1p6d 485 120 for for IN cord-022053-idft1p6d 485 121 the the DT cord-022053-idft1p6d 485 122 identification identification NN cord-022053-idft1p6d 485 123 of of IN cord-022053-idft1p6d 485 124 fungi fungus NNS cord-022053-idft1p6d 485 125 in in IN cord-022053-idft1p6d 485 126 formalin formalin NN cord-022053-idft1p6d 485 127 fixed fix VBN cord-022053-idft1p6d 485 128 , , , cord-022053-idft1p6d 485 129 paraffin paraffin NN cord-022053-idft1p6d 485 130 - - HYPH cord-022053-idft1p6d 485 131 embedded embed VBN cord-022053-idft1p6d 485 132 tissue tissue NN cord-022053-idft1p6d 485 133 specimens specimen NNS cord-022053-idft1p6d 485 134 Development development NN cord-022053-idft1p6d 485 135 and and CC cord-022053-idft1p6d 485 136 verification verification NN cord-022053-idft1p6d 485 137 of of IN cord-022053-idft1p6d 485 138 the the DT cord-022053-idft1p6d 485 139 PAM50-based PAM50-based NNP cord-022053-idft1p6d 485 140 Prosigna Prosigna NNP cord-022053-idft1p6d 485 141 breast breast NN cord-022053-idft1p6d 485 142 cancer cancer NN cord-022053-idft1p6d 485 143 gene gene NN cord-022053-idft1p6d 485 144 signature signature NN cord-022053-idft1p6d 485 145 assay assay NN cord-022053-idft1p6d 485 146 Evaluating evaluate VBG cord-022053-idft1p6d 485 147 robustness robustness NN cord-022053-idft1p6d 485 148 and and CC cord-022053-idft1p6d 485 149 sensitivity sensitivity NN cord-022053-idft1p6d 485 150 of of IN cord-022053-idft1p6d 485 151 the the DT cord-022053-idft1p6d 485 152 NanoString NanoString NNP cord-022053-idft1p6d 485 153 Technologies Technologies NNPS cord-022053-idft1p6d 485 154 nCounter nCounter NNP cord-022053-idft1p6d 485 155 Platform Platform NNP cord-022053-idft1p6d 485 156 to to TO cord-022053-idft1p6d 485 157 enable enable VB cord-022053-idft1p6d 485 158 multiplexed multiplexed JJ cord-022053-idft1p6d 485 159 gene gene NN cord-022053-idft1p6d 485 160 expression expression NN cord-022053-idft1p6d 485 161 analysis analysis NN cord-022053-idft1p6d 485 162 of of IN cord-022053-idft1p6d 485 163 clinical clinical JJ cord-022053-idft1p6d 485 164 samples sample NNS cord-022053-idft1p6d 485 165 Matrix Matrix NNP cord-022053-idft1p6d 485 166 - - HYPH cord-022053-idft1p6d 485 167 assisted assist VBN cord-022053-idft1p6d 485 168 laser laser NN cord-022053-idft1p6d 485 169 desorption desorption NN cord-022053-idft1p6d 485 170 / / SYM cord-022053-idft1p6d 485 171 ionization ionization NN cord-022053-idft1p6d 485 172 time time NN cord-022053-idft1p6d 485 173 - - HYPH cord-022053-idft1p6d 485 174 of of IN cord-022053-idft1p6d 485 175 - - HYPH cord-022053-idft1p6d 485 176 flight flight NN cord-022053-idft1p6d 485 177 mass mass NN cord-022053-idft1p6d 485 178 spectrometry spectrometry NN cord-022053-idft1p6d 485 179 identification identification NN cord-022053-idft1p6d 485 180 of of IN cord-022053-idft1p6d 485 181 mycobacteria mycobacterium NNS cord-022053-idft1p6d 485 182 in in IN cord-022053-idft1p6d 485 183 routine routine JJ cord-022053-idft1p6d 485 184 clinical clinical JJ cord-022053-idft1p6d 485 185 practice practice NN cord-022053-idft1p6d 485 186 Comparison comparison NN cord-022053-idft1p6d 485 187 of of IN cord-022053-idft1p6d 485 188 sample sample NN cord-022053-idft1p6d 485 189 preparation preparation NN cord-022053-idft1p6d 485 190 methods method NNS cord-022053-idft1p6d 485 191 , , , cord-022053-idft1p6d 485 192 instrumentation instrumentation NN cord-022053-idft1p6d 485 193 platforms platform NNS cord-022053-idft1p6d 485 194 , , , cord-022053-idft1p6d 485 195 and and CC cord-022053-idft1p6d 485 196 contemporary contemporary JJ cord-022053-idft1p6d 485 197 commercial commercial JJ cord-022053-idft1p6d 485 198 databases database NNS cord-022053-idft1p6d 485 199 for for IN cord-022053-idft1p6d 485 200 identification identification NN cord-022053-idft1p6d 485 201 of of IN cord-022053-idft1p6d 485 202 clinically clinically RB cord-022053-idft1p6d 485 203 relevant relevant JJ cord-022053-idft1p6d 485 204 mycobacteria mycobacterium NNS cord-022053-idft1p6d 485 205 by by IN cord-022053-idft1p6d 485 206 matrix matrix NN cord-022053-idft1p6d 485 207 - - HYPH cord-022053-idft1p6d 485 208 assisted assist VBN cord-022053-idft1p6d 485 209 laser laser NN cord-022053-idft1p6d 485 210 desorption desorption NN cord-022053-idft1p6d 485 211 ionization ionization NN cord-022053-idft1p6d 485 212 - - HYPH cord-022053-idft1p6d 485 213 time time NN cord-022053-idft1p6d 485 214 of of IN cord-022053-idft1p6d 485 215 flight flight NN cord-022053-idft1p6d 485 216 mass mass NN cord-022053-idft1p6d 485 217 spectrometry spectrometry NN cord-022053-idft1p6d 485 218 Identification identification NN cord-022053-idft1p6d 485 219 of of IN cord-022053-idft1p6d 485 220 mycobacteria mycobacterium NNS cord-022053-idft1p6d 485 221 from from IN cord-022053-idft1p6d 485 222 solid solid JJ cord-022053-idft1p6d 485 223 and and CC cord-022053-idft1p6d 485 224 liquid liquid JJ cord-022053-idft1p6d 485 225 media medium NNS cord-022053-idft1p6d 485 226 by by IN cord-022053-idft1p6d 485 227 matrix matrix NN cord-022053-idft1p6d 485 228 - - HYPH cord-022053-idft1p6d 485 229 assisted assist VBN cord-022053-idft1p6d 485 230 laser laser NN cord-022053-idft1p6d 485 231 desorption desorption NN cord-022053-idft1p6d 485 232 ionization ionization NN cord-022053-idft1p6d 485 233 - - HYPH cord-022053-idft1p6d 485 234 time time NN cord-022053-idft1p6d 485 235 of of IN cord-022053-idft1p6d 485 236 flight flight NN cord-022053-idft1p6d 485 237 mass mass NN cord-022053-idft1p6d 485 238 spectrometry spectrometry NN cord-022053-idft1p6d 485 239 in in IN cord-022053-idft1p6d 485 240 the the DT cord-022053-idft1p6d 485 241 clinical clinical JJ cord-022053-idft1p6d 485 242 laboratory laboratory NN cord-022053-idft1p6d 486 1 Poster poster NN cord-022053-idft1p6d 486 2 1190 1190 CD cord-022053-idft1p6d 486 3 : : : cord-022053-idft1p6d 487 1 Mycobacteria Mycobacteria NNP cord-022053-idft1p6d 487 2 Identification Identification NNP cord-022053-idft1p6d 487 3 by by IN cord-022053-idft1p6d 487 4 MALDI MALDI NNP cord-022053-idft1p6d 487 5 Biotyper Biotyper NNP cord-022053-idft1p6d 487 6 System System NNP cord-022053-idft1p6d 487 7 : : : cord-022053-idft1p6d 487 8 Evolution evolution NN cord-022053-idft1p6d 487 9 of of IN cord-022053-idft1p6d 487 10 Database Database NNP cord-022053-idft1p6d 487 11 Content Content NNP cord-022053-idft1p6d 487 12 and and CC cord-022053-idft1p6d 487 13 Evaluation Evaluation NNP cord-022053-idft1p6d 487 14 Criteria Criteria NNP cord-022053-idft1p6d 487 15 Evaluation Evaluation NNP cord-022053-idft1p6d 487 16 of of IN cord-022053-idft1p6d 487 17 MALDI MALDI NNS cord-022053-idft1p6d 488 1 Biotyper Biotyper NNP cord-022053-idft1p6d 488 2 Mycobacteria Mycobacteria NNP cord-022053-idft1p6d 488 3 Library Library NNP cord-022053-idft1p6d 488 4 v3.0 v3.0 NN cord-022053-idft1p6d 488 5 for for IN cord-022053-idft1p6d 488 6 identification identification NN cord-022053-idft1p6d 488 7 of of IN cord-022053-idft1p6d 488 8 nontuberculous nontuberculous JJ cord-022053-idft1p6d 488 9 mycobacteria mycobacterium NNS cord-022053-idft1p6d 488 10 Routine routine JJ cord-022053-idft1p6d 488 11 identification identification NN cord-022053-idft1p6d 488 12 of of IN cord-022053-idft1p6d 488 13 medical medical JJ cord-022053-idft1p6d 488 14 fungi fungus NNS cord-022053-idft1p6d 488 15 by by IN cord-022053-idft1p6d 488 16 the the DT cord-022053-idft1p6d 488 17 new new JJ cord-022053-idft1p6d 488 18 Vitek Vitek NNP cord-022053-idft1p6d 488 19 MS MS NNP cord-022053-idft1p6d 488 20 matrix matrix NN cord-022053-idft1p6d 488 21 - - HYPH cord-022053-idft1p6d 488 22 assisted assist VBN cord-022053-idft1p6d 488 23 laser laser NN cord-022053-idft1p6d 488 24 desorption desorption NN cord-022053-idft1p6d 488 25 ionization ionization NN cord-022053-idft1p6d 488 26 - - HYPH cord-022053-idft1p6d 488 27 time time NN cord-022053-idft1p6d 488 28 of of IN cord-022053-idft1p6d 488 29 flight flight NN cord-022053-idft1p6d 488 30 system system NN cord-022053-idft1p6d 488 31 with with IN cord-022053-idft1p6d 488 32 a a DT cord-022053-idft1p6d 488 33 new new JJ cord-022053-idft1p6d 488 34 time time NN cord-022053-idft1p6d 488 35 - - HYPH cord-022053-idft1p6d 488 36 effective effective JJ cord-022053-idft1p6d 488 37 strategy strategy NN cord-022053-idft1p6d 488 38 Discrimination discrimination NN cord-022053-idft1p6d 488 39 of of IN cord-022053-idft1p6d 488 40 Aspergillus Aspergillus NNP cord-022053-idft1p6d 488 41 lentulus lentulus NN cord-022053-idft1p6d 488 42 from from IN cord-022053-idft1p6d 488 43 Aspergillus aspergillus NN cord-022053-idft1p6d 488 44 fumigatus fumigatus NN cord-022053-idft1p6d 488 45 by by IN cord-022053-idft1p6d 488 46 Raman Raman NNP cord-022053-idft1p6d 488 47 spectroscopy spectroscopy NN cord-022053-idft1p6d 488 48 and and CC cord-022053-idft1p6d 488 49 MALDI MALDI NNS cord-022053-idft1p6d 488 50 - - HYPH cord-022053-idft1p6d 488 51 TOF TOF NNP cord-022053-idft1p6d 488 52 MS MS NNP cord-022053-idft1p6d 488 53 Use Use NNP cord-022053-idft1p6d 488 54 of of IN cord-022053-idft1p6d 488 55 the the DT cord-022053-idft1p6d 488 56 Bruker Bruker NNP cord-022053-idft1p6d 488 57 MALDI MALDI NNP cord-022053-idft1p6d 488 58 Biotyper Biotyper NNP cord-022053-idft1p6d 488 59 for for IN cord-022053-idft1p6d 488 60 identification identification NN cord-022053-idft1p6d 488 61 of of IN cord-022053-idft1p6d 488 62 molds mold NNS cord-022053-idft1p6d 488 63 in in IN cord-022053-idft1p6d 488 64 the the DT cord-022053-idft1p6d 488 65 clinical clinical JJ cord-022053-idft1p6d 488 66 mycology mycology NN cord-022053-idft1p6d 488 67 laboratory laboratory NNP cord-022053-idft1p6d 488 68 Evaluation Evaluation NNP cord-022053-idft1p6d 488 69 of of IN cord-022053-idft1p6d 488 70 the the DT cord-022053-idft1p6d 488 71 matrix matrix NN cord-022053-idft1p6d 488 72 - - HYPH cord-022053-idft1p6d 488 73 assisted assist VBN cord-022053-idft1p6d 488 74 laser laser NN cord-022053-idft1p6d 488 75 desorption desorption NN cord-022053-idft1p6d 488 76 / / SYM cord-022053-idft1p6d 488 77 ionization ionization NN cord-022053-idft1p6d 488 78 time time NN cord-022053-idft1p6d 488 79 - - HYPH cord-022053-idft1p6d 488 80 of of IN cord-022053-idft1p6d 488 81 - - HYPH cord-022053-idft1p6d 488 82 flight flight NN cord-022053-idft1p6d 488 83 mass mass NN cord-022053-idft1p6d 488 84 spectrometry spectrometry NN cord-022053-idft1p6d 488 85 Bruker Bruker NNP cord-022053-idft1p6d 488 86 Biotyper Biotyper NNP cord-022053-idft1p6d 488 87 for for IN cord-022053-idft1p6d 488 88 identification identification NN cord-022053-idft1p6d 488 89 of of IN cord-022053-idft1p6d 488 90 Penicillium Penicillium NNP cord-022053-idft1p6d 488 91 marneffei marneffei NNP cord-022053-idft1p6d 488 92 , , , cord-022053-idft1p6d 488 93 Paecilomyces Paecilomyces NNP cord-022053-idft1p6d 488 94 species specie NNS cord-022053-idft1p6d 488 95 , , , cord-022053-idft1p6d 488 96 Fusarium fusarium NN cord-022053-idft1p6d 488 97 solani solani NNS cord-022053-idft1p6d 488 98 , , , cord-022053-idft1p6d 488 99 Rhizopus Rhizopus NNP cord-022053-idft1p6d 488 100 species specie NNS cord-022053-idft1p6d 488 101 , , , cord-022053-idft1p6d 488 102 and and CC cord-022053-idft1p6d 488 103 Pseudallescheria Pseudallescheria NNP cord-022053-idft1p6d 488 104 boydii boydii NNP cord-022053-idft1p6d 488 105 Species Species NNP cord-022053-idft1p6d 488 106 identification identification NN cord-022053-idft1p6d 488 107 of of IN cord-022053-idft1p6d 488 108 Aspergillus aspergillus NN cord-022053-idft1p6d 488 109 , , , cord-022053-idft1p6d 488 110 Fusarium Fusarium NNP cord-022053-idft1p6d 488 111 and and CC cord-022053-idft1p6d 488 112 Mucorales Mucorales NNP cord-022053-idft1p6d 488 113 with with IN cord-022053-idft1p6d 488 114 direct direct JJ cord-022053-idft1p6d 488 115 surface surface NN cord-022053-idft1p6d 488 116 analysis analysis NN cord-022053-idft1p6d 488 117 by by IN cord-022053-idft1p6d 488 118 matrix matrix NN cord-022053-idft1p6d 488 119 - - HYPH cord-022053-idft1p6d 488 120 assisted assist VBN cord-022053-idft1p6d 488 121 laser laser NN cord-022053-idft1p6d 488 122 desorption desorption NN cord-022053-idft1p6d 488 123 ionization ionization NN cord-022053-idft1p6d 488 124 time time NN cord-022053-idft1p6d 488 125 - - HYPH cord-022053-idft1p6d 488 126 of of IN cord-022053-idft1p6d 488 127 - - HYPH cord-022053-idft1p6d 488 128 flight flight NN cord-022053-idft1p6d 488 129 mass mass NN cord-022053-idft1p6d 488 130 spectrometry spectrometry NN cord-022053-idft1p6d 488 131 Matrix Matrix NNP cord-022053-idft1p6d 488 132 - - HYPH cord-022053-idft1p6d 488 133 assisted assist VBN cord-022053-idft1p6d 488 134 laser laser NN cord-022053-idft1p6d 488 135 desorption desorption NN cord-022053-idft1p6d 488 136 ionization ionization NN cord-022053-idft1p6d 488 137 - - HYPH cord-022053-idft1p6d 488 138 time time NN cord-022053-idft1p6d 488 139 of of IN cord-022053-idft1p6d 488 140 flight flight NN cord-022053-idft1p6d 488 141 ( ( -LRB- cord-022053-idft1p6d 488 142 MALDI MALDI NNP cord-022053-idft1p6d 488 143 - - HYPH cord-022053-idft1p6d 488 144 TOF TOF NNP cord-022053-idft1p6d 488 145 ) ) -RRB- cord-022053-idft1p6d 488 146 mass mass NN cord-022053-idft1p6d 488 147 spectrometry spectrometry NN cord-022053-idft1p6d 488 148 using use VBG cord-022053-idft1p6d 488 149 the the DT cord-022053-idft1p6d 488 150 Vitek Vitek NNP cord-022053-idft1p6d 488 151 MS MS NNP cord-022053-idft1p6d 488 152 system system NN cord-022053-idft1p6d 488 153 for for IN cord-022053-idft1p6d 488 154 rapid rapid JJ cord-022053-idft1p6d 488 155 and and CC cord-022053-idft1p6d 488 156 accurate accurate JJ cord-022053-idft1p6d 488 157 identification identification NN cord-022053-idft1p6d 488 158 of of IN cord-022053-idft1p6d 488 159 dermatophytes dermatophyte NNS cord-022053-idft1p6d 488 160 on on IN cord-022053-idft1p6d 488 161 solid solid JJ cord-022053-idft1p6d 488 162 cultures culture NNS cord-022053-idft1p6d 489 1 Mould Mould NNP cord-022053-idft1p6d 489 2 routine routine JJ cord-022053-idft1p6d 489 3 identification identification NN cord-022053-idft1p6d 489 4 in in IN cord-022053-idft1p6d 489 5 the the DT cord-022053-idft1p6d 489 6 clinical clinical JJ cord-022053-idft1p6d 489 7 laboratory laboratory NN cord-022053-idft1p6d 489 8 by by IN cord-022053-idft1p6d 489 9 matrix matrix NN cord-022053-idft1p6d 489 10 - - HYPH cord-022053-idft1p6d 489 11 assisted assist VBN cord-022053-idft1p6d 489 12 laser laser NN cord-022053-idft1p6d 489 13 desorption desorption NN cord-022053-idft1p6d 489 14 ionization ionization NN cord-022053-idft1p6d 489 15 time time NN cord-022053-idft1p6d 489 16 - - HYPH cord-022053-idft1p6d 489 17 of of IN cord-022053-idft1p6d 489 18 - - HYPH cord-022053-idft1p6d 489 19 flight flight NN cord-022053-idft1p6d 489 20 mass mass NN cord-022053-idft1p6d 489 21 spectrometry spectrometry NN cord-022053-idft1p6d 489 22 MALDI MALDI NNP cord-022053-idft1p6d 489 23 - - HYPH cord-022053-idft1p6d 489 24 TOF TOF NNP cord-022053-idft1p6d 489 25 mass mass NN cord-022053-idft1p6d 489 26 spectrometry spectrometry NN cord-022053-idft1p6d 489 27 identification identification NN cord-022053-idft1p6d 489 28 of of IN cord-022053-idft1p6d 489 29 filamentous filamentous JJ cord-022053-idft1p6d 489 30 fungi fungus NNS cord-022053-idft1p6d 489 31 in in IN cord-022053-idft1p6d 489 32 the the DT cord-022053-idft1p6d 489 33 clinical clinical JJ cord-022053-idft1p6d 489 34 laboratory laboratory NN cord-022053-idft1p6d 489 35 Identification identification NN cord-022053-idft1p6d 489 36 of of IN cord-022053-idft1p6d 489 37 filamentous filamentous JJ cord-022053-idft1p6d 489 38 fungi fungi NN cord-022053-idft1p6d 489 39 isolates isolate NNS cord-022053-idft1p6d 489 40 by by IN cord-022053-idft1p6d 489 41 MALDI MALDI NNP cord-022053-idft1p6d 489 42 - - HYPH cord-022053-idft1p6d 489 43 TOF TOF NNP cord-022053-idft1p6d 489 44 mass mass NN cord-022053-idft1p6d 489 45 spectrometry spectrometry NN cord-022053-idft1p6d 489 46 : : : cord-022053-idft1p6d 489 47 clinical clinical JJ cord-022053-idft1p6d 489 48 evaluation evaluation NN cord-022053-idft1p6d 489 49 of of IN cord-022053-idft1p6d 489 50 an an DT cord-022053-idft1p6d 489 51 extended extended JJ cord-022053-idft1p6d 489 52 reference reference NN cord-022053-idft1p6d 489 53 spectra spectra NNP cord-022053-idft1p6d 489 54 library library NN cord-022053-idft1p6d 489 55 Assessment Assessment NNP cord-022053-idft1p6d 489 56 of of IN cord-022053-idft1p6d 489 57 various various JJ cord-022053-idft1p6d 489 58 parameters parameter NNS cord-022053-idft1p6d 489 59 to to TO cord-022053-idft1p6d 489 60 improve improve VB cord-022053-idft1p6d 489 61 MALDI MALDI NNP cord-022053-idft1p6d 489 62 - - HYPH cord-022053-idft1p6d 489 63 TOF TOF NNP cord-022053-idft1p6d 489 64 MS MS NNP cord-022053-idft1p6d 489 65 reference reference NN cord-022053-idft1p6d 489 66 spectra spectra NNP cord-022053-idft1p6d 489 67 libraries library NNS cord-022053-idft1p6d 489 68 constructed construct VBN cord-022053-idft1p6d 489 69 for for IN cord-022053-idft1p6d 489 70 the the DT cord-022053-idft1p6d 489 71 routine routine JJ cord-022053-idft1p6d 489 72 identification identification NN cord-022053-idft1p6d 489 73 of of IN cord-022053-idft1p6d 489 74 filamentous filamentous JJ cord-022053-idft1p6d 489 75 fungi fungus NNS cord-022053-idft1p6d 489 76 Detection detection NN cord-022053-idft1p6d 489 77 of of IN cord-022053-idft1p6d 489 78 microorganisms microorganism NNS cord-022053-idft1p6d 489 79 in in IN cord-022053-idft1p6d 489 80 blood blood NN cord-022053-idft1p6d 489 81 specimens specimen NNS cord-022053-idft1p6d 489 82 using use VBG cord-022053-idft1p6d 489 83 matrix matrix NN cord-022053-idft1p6d 489 84 - - HYPH cord-022053-idft1p6d 489 85 assisted assist VBN cord-022053-idft1p6d 489 86 laser laser NN cord-022053-idft1p6d 489 87 desorption desorption NN cord-022053-idft1p6d 489 88 ionization ionization NN cord-022053-idft1p6d 489 89 time time NN cord-022053-idft1p6d 489 90 - - HYPH cord-022053-idft1p6d 489 91 of of IN cord-022053-idft1p6d 489 92 - - HYPH cord-022053-idft1p6d 489 93 flight flight NN cord-022053-idft1p6d 489 94 mass mass NN cord-022053-idft1p6d 489 95 spectrometry spectrometry NN cord-022053-idft1p6d 489 96 : : : cord-022053-idft1p6d 489 97 a a DT cord-022053-idft1p6d 489 98 review review NN cord-022053-idft1p6d 489 99 Sepsis sepsis NN cord-022053-idft1p6d 489 100 : : : cord-022053-idft1p6d 489 101 a a DT cord-022053-idft1p6d 489 102 roadmap roadmap NN cord-022053-idft1p6d 489 103 for for IN cord-022053-idft1p6d 489 104 future future JJ cord-022053-idft1p6d 489 105 research research NN cord-022053-idft1p6d 489 106 Direct direct JJ cord-022053-idft1p6d 489 107 identification identification NN cord-022053-idft1p6d 489 108 of of IN cord-022053-idft1p6d 489 109 urinary urinary JJ cord-022053-idft1p6d 489 110 tract tract NN cord-022053-idft1p6d 489 111 pathogens pathogen NNS cord-022053-idft1p6d 489 112 from from IN cord-022053-idft1p6d 489 113 urine urine NN cord-022053-idft1p6d 489 114 samples sample NNS cord-022053-idft1p6d 489 115 , , , cord-022053-idft1p6d 489 116 combining combine VBG cord-022053-idft1p6d 489 117 urine urine NN cord-022053-idft1p6d 489 118 of of IN cord-022053-idft1p6d 489 119 human human JJ cord-022053-idft1p6d 489 120 papillomaviruses papillomaviruse NNS cord-022053-idft1p6d 489 121 ( ( -LRB- cord-022053-idft1p6d 489 122 HPV HPV NNP cord-022053-idft1p6d 489 123 ) ) -RRB- cord-022053-idft1p6d 489 124 in in IN cord-022053-idft1p6d 489 125 oropharyngeal oropharyngeal JJ cord-022053-idft1p6d 489 126 squamous squamous JJ cord-022053-idft1p6d 489 127 cell cell NN cord-022053-idft1p6d 489 128 carcinoma carcinoma NN cord-022053-idft1p6d 489 129 ( ( -LRB- cord-022053-idft1p6d 489 130 OPSCC OPSCC NNP cord-022053-idft1p6d 489 131 ) ) -RRB- cord-022053-idft1p6d 490 1 Isothermal isothermal JJ cord-022053-idft1p6d 490 2 multiple multiple JJ cord-022053-idft1p6d 490 3 displacement displacement NN cord-022053-idft1p6d 490 4 amplification amplification NN cord-022053-idft1p6d 490 5 : : : cord-022053-idft1p6d 490 6 a a DT cord-022053-idft1p6d 490 7 methodical methodical JJ cord-022053-idft1p6d 490 8 approach approach NN cord-022053-idft1p6d 490 9 enhancing enhance VBG cord-022053-idft1p6d 490 10 molecular molecular JJ cord-022053-idft1p6d 490 11 routine routine JJ cord-022053-idft1p6d 490 12 diagnostics diagnostic NNS cord-022053-idft1p6d 490 13 of of IN cord-022053-idft1p6d 490 14 microcarcinomas microcarcinomas NN cord-022053-idft1p6d 490 15 and and CC cord-022053-idft1p6d 490 16 small small JJ cord-022053-idft1p6d 490 17 biopsies biopsy NNS cord-022053-idft1p6d 490 18 Point point NN cord-022053-idft1p6d 490 19 - - HYPH cord-022053-idft1p6d 490 20 counterpoint counterpoint NN cord-022053-idft1p6d 490 21 : : : cord-022053-idft1p6d 490 22 large large JJ cord-022053-idft1p6d 490 23 multiplex multiplex NN cord-022053-idft1p6d 490 24 PCR pcr NN cord-022053-idft1p6d 490 25 panels panel NNS cord-022053-idft1p6d 490 26 should should MD cord-022053-idft1p6d 490 27 be be VB cord-022053-idft1p6d 490 28 first first JJ cord-022053-idft1p6d 490 29 - - HYPH cord-022053-idft1p6d 490 30 line line NN cord-022053-idft1p6d 490 31 tests test NNS cord-022053-idft1p6d 490 32 for for IN cord-022053-idft1p6d 490 33 detection detection NN cord-022053-idft1p6d 490 34 of of IN cord-022053-idft1p6d 490 35 respiratory respiratory JJ cord-022053-idft1p6d 490 36 and and CC cord-022053-idft1p6d 490 37 intestinal intestinal JJ cord-022053-idft1p6d 490 38 pathogens pathogen NNS cord-022053-idft1p6d 490 39 Emerging emerge VBG cord-022053-idft1p6d 490 40 technologies technology NNS cord-022053-idft1p6d 490 41 for for IN cord-022053-idft1p6d 490 42 the the DT cord-022053-idft1p6d 490 43 clinical clinical JJ cord-022053-idft1p6d 490 44 microbiology microbiology NN cord-022053-idft1p6d 490 45 laboratory laboratory NN cord-022053-idft1p6d 491 1 Basic basic JJ cord-022053-idft1p6d 491 2 concepts concept NNS cord-022053-idft1p6d 491 3 of of IN cord-022053-idft1p6d 491 4 microarrays microarray NNS cord-022053-idft1p6d 491 5 and and CC cord-022053-idft1p6d 491 6 potential potential JJ cord-022053-idft1p6d 491 7 applications application NNS cord-022053-idft1p6d 491 8 in in IN cord-022053-idft1p6d 491 9 clinical clinical JJ cord-022053-idft1p6d 491 10 microbiology microbiology NN cord-022053-idft1p6d 491 11 Molecular molecular JJ cord-022053-idft1p6d 491 12 diagnosis diagnosis NN cord-022053-idft1p6d 491 13 of of IN cord-022053-idft1p6d 491 14 respiratory respiratory JJ cord-022053-idft1p6d 491 15 viruses virus NNS cord-022053-idft1p6d 492 1 Molecular molecular JJ cord-022053-idft1p6d 492 2 Pathology Pathology NNP cord-022053-idft1p6d 492 3 in in IN cord-022053-idft1p6d 492 4 Clinical Clinical NNP cord-022053-idft1p6d 492 5 Practice Practice NNP cord-022053-idft1p6d 492 6 Community Community NNP cord-022053-idft1p6d 492 7 - - HYPH cord-022053-idft1p6d 492 8 acquired acquire VBN cord-022053-idft1p6d 492 9 pneumonia pneumonia NN cord-022053-idft1p6d 492 10 requiring require VBG cord-022053-idft1p6d 492 11 hospitalization hospitalization NN cord-022053-idft1p6d 492 12 among among IN cord-022053-idft1p6d 493 1 U.S. U.S. NNP cord-022053-idft1p6d 493 2 adults adult NNS cord-022053-idft1p6d 493 3 Pertussis pertussis NN cord-022053-idft1p6d 493 4 : : : cord-022053-idft1p6d 493 5 microbiology microbiology NN cord-022053-idft1p6d 493 6 , , , cord-022053-idft1p6d 493 7 disease disease NN cord-022053-idft1p6d 493 8 , , , cord-022053-idft1p6d 493 9 treatment treatment NN cord-022053-idft1p6d 493 10 , , , cord-022053-idft1p6d 493 11 and and CC cord-022053-idft1p6d 493 12 prevention prevention NN cord-022053-idft1p6d 493 13 Laboratory laboratory NN cord-022053-idft1p6d 493 14 diagnosis diagnosis NN cord-022053-idft1p6d 493 15 of of IN cord-022053-idft1p6d 493 16 bacterial bacterial JJ cord-022053-idft1p6d 493 17 gastroenteritis gastroenteritis NN cord-022053-idft1p6d 493 18 Molecular molecular JJ cord-022053-idft1p6d 493 19 testing testing NN cord-022053-idft1p6d 493 20 for for IN cord-022053-idft1p6d 493 21 viral viral JJ cord-022053-idft1p6d 493 22 and and CC cord-022053-idft1p6d 493 23 bacterial bacterial JJ cord-022053-idft1p6d 493 24 enteric enteric JJ cord-022053-idft1p6d 493 25 pathogens pathogen NNS cord-022053-idft1p6d 493 26 : : : cord-022053-idft1p6d 493 27 gold gold NN cord-022053-idft1p6d 493 28 standard standard NN cord-022053-idft1p6d 493 29 for for IN cord-022053-idft1p6d 493 30 viruses virus NNS cord-022053-idft1p6d 493 31 , , , cord-022053-idft1p6d 493 32 but but CC cord-022053-idft1p6d 493 33 do do VB cord-022053-idft1p6d 493 34 n't not RB cord-022053-idft1p6d 493 35 let let VB cord-022053-idft1p6d 493 36 culture culture NN cord-022053-idft1p6d 493 37 go go VB cord-022053-idft1p6d 493 38 just just RB cord-022053-idft1p6d 493 39 yet yet RB cord-022053-idft1p6d 493 40 ? ? . cord-022053-idft1p6d 494 1 Multiplex multiplex NN cord-022053-idft1p6d 494 2 polymerase polymerase NN cord-022053-idft1p6d 494 3 chain chain NN cord-022053-idft1p6d 494 4 reaction reaction NN cord-022053-idft1p6d 494 5 tests test NNS cord-022053-idft1p6d 494 6 for for IN cord-022053-idft1p6d 494 7 detection detection NN cord-022053-idft1p6d 494 8 of of IN cord-022053-idft1p6d 494 9 pathogens pathogen NNS cord-022053-idft1p6d 494 10 associated associate VBN cord-022053-idft1p6d 494 11 with with IN cord-022053-idft1p6d 494 12 gastroenteritis gastroenteritis JJ cord-022053-idft1p6d 494 13 Advances advance NNS cord-022053-idft1p6d 494 14 in in IN cord-022053-idft1p6d 494 15 molecular molecular JJ cord-022053-idft1p6d 494 16 diagnosis diagnosis NN cord-022053-idft1p6d 494 17 of of IN cord-022053-idft1p6d 494 18 parasitic parasitic JJ cord-022053-idft1p6d 494 19 enteropathogens enteropathogen NNS cord-022053-idft1p6d 494 20 Multiplex Multiplex NNP cord-022053-idft1p6d 494 21 PCR PCR NNP cord-022053-idft1p6d 494 22 testing testing NN cord-022053-idft1p6d 494 23 for for IN cord-022053-idft1p6d 494 24 nine nine CD cord-022053-idft1p6d 494 25 different different JJ cord-022053-idft1p6d 494 26 sexually sexually RB cord-022053-idft1p6d 494 27 transmitted transmit VBN cord-022053-idft1p6d 494 28 infections infection NNS cord-022053-idft1p6d 495 1 Nosocomial nosocomial JJ cord-022053-idft1p6d 495 2 bacterial bacterial JJ cord-022053-idft1p6d 495 3 meningitis meningitis NN cord-022053-idft1p6d 495 4 State state NN cord-022053-idft1p6d 495 5 - - HYPH cord-022053-idft1p6d 495 6 of of IN cord-022053-idft1p6d 495 7 - - HYPH cord-022053-idft1p6d 495 8 the the DT cord-022053-idft1p6d 495 9 - - HYPH cord-022053-idft1p6d 495 10 art art NN cord-022053-idft1p6d 495 11 microbiologic microbiologic JJ cord-022053-idft1p6d 495 12 testing testing NN cord-022053-idft1p6d 495 13 for for IN cord-022053-idft1p6d 495 14 community community NN cord-022053-idft1p6d 495 15 - - HYPH cord-022053-idft1p6d 495 16 acquired acquire VBN cord-022053-idft1p6d 495 17 meningitis meningitis NN cord-022053-idft1p6d 495 18 and and CC cord-022053-idft1p6d 495 19 encephalitis encephalitis NN cord-022053-idft1p6d 495 20 Epidemiology epidemiology NN cord-022053-idft1p6d 495 21 , , , cord-022053-idft1p6d 495 22 diagnosis diagnosis NN cord-022053-idft1p6d 495 23 , , , cord-022053-idft1p6d 495 24 and and CC cord-022053-idft1p6d 495 25 antimicrobial antimicrobial JJ cord-022053-idft1p6d 495 26 treatment treatment NN cord-022053-idft1p6d 495 27 of of IN cord-022053-idft1p6d 495 28 acute acute JJ cord-022053-idft1p6d 495 29 bacterial bacterial JJ cord-022053-idft1p6d 495 30 meningitis meningitis NN cord-022053-idft1p6d 495 31 Diagnostic diagnostic JJ cord-022053-idft1p6d 495 32 performance performance NN cord-022053-idft1p6d 495 33 of of IN cord-022053-idft1p6d 495 34 a a DT cord-022053-idft1p6d 495 35 multiplex multiplex JJ cord-022053-idft1p6d 495 36 PCR pcr NN cord-022053-idft1p6d 495 37 assay assay NN cord-022053-idft1p6d 495 38 for for IN cord-022053-idft1p6d 495 39 meningitis meningitis NN cord-022053-idft1p6d 495 40 in in IN cord-022053-idft1p6d 495 41 an an DT cord-022053-idft1p6d 495 42 HIV HIV NNP cord-022053-idft1p6d 495 43 - - HYPH cord-022053-idft1p6d 495 44 infected infect VBN cord-022053-idft1p6d 495 45 population population NN cord-022053-idft1p6d 495 46 in in IN cord-022053-idft1p6d 495 47 Uganda Uganda NNP cord-022053-idft1p6d 495 48 Two two CD cord-022053-idft1p6d 495 49 decades decade NNS cord-022053-idft1p6d 495 50 of of IN cord-022053-idft1p6d 495 51 mortality mortality NN cord-022053-idft1p6d 495 52 trends trend NNS cord-022053-idft1p6d 495 53 among among IN cord-022053-idft1p6d 495 54 patients patient NNS cord-022053-idft1p6d 495 55 with with IN cord-022053-idft1p6d 495 56 severe severe JJ cord-022053-idft1p6d 495 57 sepsis sepsis NN cord-022053-idft1p6d 495 58 : : : cord-022053-idft1p6d 495 59 a a DT cord-022053-idft1p6d 495 60 comparative comparative JJ cord-022053-idft1p6d 495 61 meta meta NN cord-022053-idft1p6d 495 62 - - HYPH cord-022053-idft1p6d 495 63 analysis analysis NN cord-022053-idft1p6d 496 1 The the DT cord-022053-idft1p6d 496 2 clinical clinical JJ cord-022053-idft1p6d 496 3 and and CC cord-022053-idft1p6d 496 4 prognostic prognostic JJ cord-022053-idft1p6d 496 5 importance importance NN cord-022053-idft1p6d 496 6 of of IN cord-022053-idft1p6d 496 7 positive positive JJ cord-022053-idft1p6d 496 8 blood blood NN cord-022053-idft1p6d 496 9 cultures culture NNS cord-022053-idft1p6d 496 10 in in IN cord-022053-idft1p6d 496 11 adults adult NNS cord-022053-idft1p6d 496 12 Laboratory Laboratory NNP cord-022053-idft1p6d 496 13 detection detection NN cord-022053-idft1p6d 496 14 of of IN cord-022053-idft1p6d 496 15 bacteremia bacteremia NN cord-022053-idft1p6d 496 16 and and CC cord-022053-idft1p6d 496 17 fungemia fungemia NN cord-022053-idft1p6d 497 1 Predicting predict VBG cord-022053-idft1p6d 497 2 bacteremia bacteremia NN cord-022053-idft1p6d 497 3 in in IN cord-022053-idft1p6d 497 4 patients patient NNS cord-022053-idft1p6d 497 5 with with IN cord-022053-idft1p6d 497 6 sepsis sepsis NN cord-022053-idft1p6d 497 7 syndrome syndrome NN cord-022053-idft1p6d 497 8 . . . cord-022053-idft1p6d 498 1 Academic Academic NNP cord-022053-idft1p6d 498 2 Medical Medical NNP cord-022053-idft1p6d 498 3 Center Center NNP cord-022053-idft1p6d 498 4 Consortium Consortium NNP cord-022053-idft1p6d 498 5 Sepsis Sepsis NNP cord-022053-idft1p6d 498 6 Project Project NNP cord-022053-idft1p6d 499 1 Working Working NNP cord-022053-idft1p6d 499 2 Group Group NNP cord-022053-idft1p6d 499 3 Quantitative Quantitative NNP cord-022053-idft1p6d 499 4 aspects aspect NNS cord-022053-idft1p6d 499 5 of of IN cord-022053-idft1p6d 499 6 septicemia septicemia NN cord-022053-idft1p6d 500 1 A a DT cord-022053-idft1p6d 500 2 cross cross JJ cord-022053-idft1p6d 500 3 comparison comparison NN cord-022053-idft1p6d 500 4 of of IN cord-022053-idft1p6d 500 5 technologies technology NNS cord-022053-idft1p6d 500 6 for for IN cord-022053-idft1p6d 500 7 the the DT cord-022053-idft1p6d 500 8 detection detection NN cord-022053-idft1p6d 500 9 of of IN cord-022053-idft1p6d 500 10 microRNAs microRNAs NNPS cord-022053-idft1p6d 500 11 in in IN cord-022053-idft1p6d 500 12 clinical clinical JJ cord-022053-idft1p6d 500 13 FFPE ffpe NN cord-022053-idft1p6d 500 14 samples sample NNS cord-022053-idft1p6d 500 15 of of IN cord-022053-idft1p6d 500 16 hepatoblastoma hepatoblastoma NNS cord-022053-idft1p6d 500 17 patients patient NNS cord-022053-idft1p6d 500 18 Plasmodium Plasmodium NNP cord-022053-idft1p6d 500 19 falciparum falciparum NN cord-022053-idft1p6d 500 20 gene gene NN cord-022053-idft1p6d 500 21 expression expression NN cord-022053-idft1p6d 500 22 measured measure VBN cord-022053-idft1p6d 500 23 directly directly RB cord-022053-idft1p6d 500 24 from from IN cord-022053-idft1p6d 500 25 tissue tissue NN cord-022053-idft1p6d 500 26 during during IN cord-022053-idft1p6d 500 27 human human JJ cord-022053-idft1p6d 500 28 infection infection NN cord-022053-idft1p6d 501 1 Molecular molecular JJ cord-022053-idft1p6d 501 2 microbiology microbiology NN cord-022053-idft1p6d 501 3 Comparison comparison NN cord-022053-idft1p6d 501 4 of of IN cord-022053-idft1p6d 501 5 the the DT cord-022053-idft1p6d 501 6 next next JJ cord-022053-idft1p6d 501 7 - - HYPH cord-022053-idft1p6d 501 8 generation generation NN cord-022053-idft1p6d 501 9 Xpert Xpert NNP cord-022053-idft1p6d 501 10 MRSA MRSA NNP cord-022053-idft1p6d 501 11 / / SYM cord-022053-idft1p6d 501 12 SA SA NNP cord-022053-idft1p6d 501 13 BC BC NNP cord-022053-idft1p6d 501 14 assay assay NN cord-022053-idft1p6d 501 15 and and CC cord-022053-idft1p6d 501 16 the the DT cord-022053-idft1p6d 501 17 GeneOhm GeneOhm NNP cord-022053-idft1p6d 501 18 StaphSR StaphSR NNP cord-022053-idft1p6d 501 19 assay assay NN cord-022053-idft1p6d 501 20 to to IN cord-022053-idft1p6d 501 21 routine routine JJ cord-022053-idft1p6d 501 22 culture culture NN cord-022053-idft1p6d 501 23 for for IN cord-022053-idft1p6d 501 24 identification identification NN cord-022053-idft1p6d 501 25 of of IN cord-022053-idft1p6d 501 26 Staphylococcus Staphylococcus NNP cord-022053-idft1p6d 501 27 aureus aureus NN cord-022053-idft1p6d 501 28 and and CC cord-022053-idft1p6d 501 29 methicillin methicillin NN cord-022053-idft1p6d 501 30 - - HYPH cord-022053-idft1p6d 501 31 resistant resistant JJ cord-022053-idft1p6d 501 32 S. S. NNP cord-022053-idft1p6d 501 33 aureus aureus NN cord-022053-idft1p6d 501 34 in in IN cord-022053-idft1p6d 501 35 positive positive JJ cord-022053-idft1p6d 501 36 - - HYPH cord-022053-idft1p6d 501 37 blood blood NN cord-022053-idft1p6d 501 38 - - HYPH cord-022053-idft1p6d 501 39 culture culture NN cord-022053-idft1p6d 501 40 broths broth NNS cord-022053-idft1p6d 502 1 Multicenter multicenter JJ cord-022053-idft1p6d 502 2 evaluation evaluation NN cord-022053-idft1p6d 502 3 of of IN cord-022053-idft1p6d 502 4 the the DT cord-022053-idft1p6d 502 5 Xpert Xpert NNP cord-022053-idft1p6d 502 6 Norovirus Norovirus NNP cord-022053-idft1p6d 502 7 assay assay NN cord-022053-idft1p6d 502 8 for for IN cord-022053-idft1p6d 502 9 detection detection NN cord-022053-idft1p6d 502 10 of of IN cord-022053-idft1p6d 502 11 Norovirus Norovirus NNP cord-022053-idft1p6d 502 12 genogroups genogroup NNS cord-022053-idft1p6d 502 13 I -PRON- PRP cord-022053-idft1p6d 502 14 and and CC cord-022053-idft1p6d 502 15 II II NNP cord-022053-idft1p6d 502 16 in in IN cord-022053-idft1p6d 502 17 fecal fecal JJ cord-022053-idft1p6d 502 18 specimens specimen NNS cord-022053-idft1p6d 503 1 Multicenter multicenter JJ cord-022053-idft1p6d 503 2 evaluation evaluation NN cord-022053-idft1p6d 503 3 of of IN cord-022053-idft1p6d 503 4 the the DT cord-022053-idft1p6d 503 5 Cepheid Cepheid NNP cord-022053-idft1p6d 503 6 Xpert Xpert NNP cord-022053-idft1p6d 503 7 methicillin methicillin NN cord-022053-idft1p6d 503 8 - - HYPH cord-022053-idft1p6d 503 9 resistant resistant JJ cord-022053-idft1p6d 503 10 Staphylococcus Staphylococcus NNP cord-022053-idft1p6d 503 11 aureus aureus NN cord-022053-idft1p6d 503 12 ( ( -LRB- cord-022053-idft1p6d 503 13 MRSA MRSA NNP cord-022053-idft1p6d 503 14 ) ) -RRB- cord-022053-idft1p6d 503 15 test test NN cord-022053-idft1p6d 503 16 as as IN cord-022053-idft1p6d 503 17 a a DT cord-022053-idft1p6d 503 18 rapid rapid JJ cord-022053-idft1p6d 503 19 screening screening NN cord-022053-idft1p6d 503 20 method method NN cord-022053-idft1p6d 503 21 for for IN cord-022053-idft1p6d 503 22 detection detection NN cord-022053-idft1p6d 503 23 of of IN cord-022053-idft1p6d 503 24 MRSA MRSA NNP cord-022053-idft1p6d 503 25 in in IN cord-022053-idft1p6d 503 26 nares nares JJ cord-022053-idft1p6d 503 27 Charnot Charnot NNP cord-022053-idft1p6d 503 28 - - HYPH cord-022053-idft1p6d 503 29 Katsikas Katsikas NNP cord-022053-idft1p6d 503 30 A. a. NN cord-022053-idft1p6d 503 31 Comparison comparison NN cord-022053-idft1p6d 503 32 of of IN cord-022053-idft1p6d 503 33 Cepheid Cepheid NNP cord-022053-idft1p6d 503 34 Xpert(R Xpert(R NNP cord-022053-idft1p6d 503 35 ) ) -RRB- cord-022053-idft1p6d 504 1 Flu/ flu/ VB cord-022053-idft1p6d 505 1 RSV RSV NNP cord-022053-idft1p6d 505 2 XC XC NNP cord-022053-idft1p6d 505 3 and and CC cord-022053-idft1p6d 505 4 BioFire BioFire NNP cord-022053-idft1p6d 505 5 FilmArray(R filmarray(r ADD cord-022053-idft1p6d 505 6 ) ) -RRB- cord-022053-idft1p6d 506 1 for for IN cord-022053-idft1p6d 506 2 detection detection NN cord-022053-idft1p6d 506 3 of of IN cord-022053-idft1p6d 506 4 influenza influenza NN cord-022053-idft1p6d 506 5 A a NN cord-022053-idft1p6d 506 6 , , , cord-022053-idft1p6d 506 7 influenza influenza NN cord-022053-idft1p6d 506 8 B b NN cord-022053-idft1p6d 506 9 , , , cord-022053-idft1p6d 506 10 and and CC cord-022053-idft1p6d 506 11 respiratory respiratory JJ cord-022053-idft1p6d 506 12 syncytial syncytial JJ cord-022053-idft1p6d 506 13 virus virus NN cord-022053-idft1p6d 506 14 T2 t2 NN cord-022053-idft1p6d 506 15 magnetic magnetic JJ cord-022053-idft1p6d 506 16 resonance resonance NN cord-022053-idft1p6d 506 17 enables enable VBZ cord-022053-idft1p6d 506 18 nanoparticle nanoparticle NN cord-022053-idft1p6d 506 19 - - HYPH cord-022053-idft1p6d 506 20 mediated mediate VBN cord-022053-idft1p6d 506 21 rapid rapid JJ cord-022053-idft1p6d 506 22 detection detection NN cord-022053-idft1p6d 506 23 of of IN cord-022053-idft1p6d 506 24 candidemia candidemia NN cord-022053-idft1p6d 506 25 in in IN cord-022053-idft1p6d 506 26 whole whole JJ cord-022053-idft1p6d 506 27 blood blood NN cord-022053-idft1p6d 506 28 T2 T2 NNP cord-022053-idft1p6d 506 29 magnetic magnetic JJ cord-022053-idft1p6d 506 30 resonance resonance NN cord-022053-idft1p6d 506 31 assay assay NN cord-022053-idft1p6d 506 32 for for IN cord-022053-idft1p6d 506 33 the the DT cord-022053-idft1p6d 506 34 rapid rapid JJ cord-022053-idft1p6d 506 35 diagnosis diagnosis NN cord-022053-idft1p6d 506 36 of of IN cord-022053-idft1p6d 506 37 candidemia candidemia NN cord-022053-idft1p6d 506 38 in in IN cord-022053-idft1p6d 506 39 whole whole JJ cord-022053-idft1p6d 506 40 blood blood NN cord-022053-idft1p6d 506 41 : : : cord-022053-idft1p6d 506 42 a a DT cord-022053-idft1p6d 506 43 clinical clinical JJ cord-022053-idft1p6d 506 44 trial trial NN cord-022053-idft1p6d 506 45 T2Bacteria T2Bacteria NNS cord-022053-idft1p6d 506 46 : : : cord-022053-idft1p6d 506 47 rapid rapid JJ cord-022053-idft1p6d 506 48 and and CC cord-022053-idft1p6d 506 49 sensitive sensitive JJ cord-022053-idft1p6d 506 50 detection detection NN cord-022053-idft1p6d 506 51 and and CC cord-022053-idft1p6d 506 52 identification identification NN cord-022053-idft1p6d 506 53 of of IN cord-022053-idft1p6d 506 54 sepsis sepsis NN cord-022053-idft1p6d 506 55 pathogens pathogen NNS cord-022053-idft1p6d 506 56 in in IN cord-022053-idft1p6d 506 57 whole whole JJ cord-022053-idft1p6d 506 58 blood blood NN cord-022053-idft1p6d 506 59 specimens specimen NNS cord-022053-idft1p6d 506 60 by by IN cord-022053-idft1p6d 506 61 T2MR t2mr NN cord-022053-idft1p6d 507 1 ( ( -LRB- cord-022053-idft1p6d 507 2 poster poster NN cord-022053-idft1p6d 507 3 ) ) -RRB- cord-022053-idft1p6d 507 4 Evaluation Evaluation NNP cord-022053-idft1p6d 507 5 of of IN cord-022053-idft1p6d 507 6 two two CD cord-022053-idft1p6d 507 7 commercial commercial JJ cord-022053-idft1p6d 507 8 loop loop NN cord-022053-idft1p6d 507 9 - - HYPH cord-022053-idft1p6d 507 10 mediated mediate VBN cord-022053-idft1p6d 507 11 isothermal isothermal JJ cord-022053-idft1p6d 507 12 amplification amplification NN cord-022053-idft1p6d 507 13 assays assay NNS cord-022053-idft1p6d 507 14 for for IN cord-022053-idft1p6d 507 15 detection detection NN cord-022053-idft1p6d 507 16 of of IN cord-022053-idft1p6d 507 17 avian avian JJ cord-022053-idft1p6d 507 18 influenza influenza NN cord-022053-idft1p6d 507 19 H5 H5 NNP cord-022053-idft1p6d 507 20 and and CC cord-022053-idft1p6d 507 21 H7 H7 NNP cord-022053-idft1p6d 507 22 hemagglutinin hemagglutinin NN cord-022053-idft1p6d 507 23 genes gene NNS cord-022053-idft1p6d 508 1 A a DT cord-022053-idft1p6d 508 2 comparison comparison NN cord-022053-idft1p6d 508 3 of of IN cord-022053-idft1p6d 508 4 in in IN cord-022053-idft1p6d 508 5 - - HYPH cord-022053-idft1p6d 508 6 house house NN cord-022053-idft1p6d 508 7 real real JJ cord-022053-idft1p6d 508 8 - - HYPH cord-022053-idft1p6d 508 9 time time NN cord-022053-idft1p6d 508 10 LAMP lamp NN cord-022053-idft1p6d 508 11 assays assay NNS cord-022053-idft1p6d 508 12 with with IN cord-022053-idft1p6d 508 13 a a DT cord-022053-idft1p6d 508 14 commercial commercial JJ cord-022053-idft1p6d 508 15 assay assay NN cord-022053-idft1p6d 508 16 for for IN cord-022053-idft1p6d 508 17 the the DT cord-022053-idft1p6d 508 18 detection detection NN cord-022053-idft1p6d 508 19 of of IN cord-022053-idft1p6d 508 20 pathogenic pathogenic JJ cord-022053-idft1p6d 508 21 bacteria bacteria NNS cord-022053-idft1p6d 508 22 Loop loop NN cord-022053-idft1p6d 508 23 - - HYPH cord-022053-idft1p6d 508 24 mediated mediate VBN cord-022053-idft1p6d 508 25 isothermal isothermal JJ cord-022053-idft1p6d 508 26 amplification amplification NN cord-022053-idft1p6d 508 27 ( ( -LRB- cord-022053-idft1p6d 508 28 LAMP lamp NN cord-022053-idft1p6d 508 29 ) ) -RRB- cord-022053-idft1p6d 508 30 for for IN cord-022053-idft1p6d 508 31 point point NN cord-022053-idft1p6d 508 32 - - HYPH cord-022053-idft1p6d 508 33 of of IN cord-022053-idft1p6d 508 34 - - HYPH cord-022053-idft1p6d 508 35 care care NN cord-022053-idft1p6d 508 36 detection detection NN cord-022053-idft1p6d 508 37 of of IN cord-022053-idft1p6d 508 38 asymptomatic asymptomatic JJ cord-022053-idft1p6d 508 39 low low JJ cord-022053-idft1p6d 508 40 - - HYPH cord-022053-idft1p6d 508 41 density density NN cord-022053-idft1p6d 508 42 malaria malaria NN cord-022053-idft1p6d 508 43 parasite parasite NN cord-022053-idft1p6d 508 44 carriers carrier NNS cord-022053-idft1p6d 508 45 in in IN cord-022053-idft1p6d 508 46 Zanzibar Zanzibar NNP cord-022053-idft1p6d 508 47 Up Up NNP cord-022053-idft1p6d 508 48 - - HYPH cord-022053-idft1p6d 508 49 date date NN cord-022053-idft1p6d 508 50 on on IN cord-022053-idft1p6d 508 51 diagnostic diagnostic JJ cord-022053-idft1p6d 508 52 strategies strategy NNS cord-022053-idft1p6d 508 53 of of IN cord-022053-idft1p6d 508 54 invasive invasive JJ cord-022053-idft1p6d 508 55 aspergillosis aspergillosis NN cord-022053-idft1p6d 509 1 The the DT cord-022053-idft1p6d 509 2 Use Use NNP cord-022053-idft1p6d 509 3 of of IN cord-022053-idft1p6d 509 4 a a DT cord-022053-idft1p6d 509 5 Commercial Commercial NNP cord-022053-idft1p6d 509 6 Loop Loop NNP cord-022053-idft1p6d 509 7 - - HYPH cord-022053-idft1p6d 509 8 Mediated mediate VBN cord-022053-idft1p6d 509 9 Isothermal Isothermal NNP cord-022053-idft1p6d 509 10 Amplification Amplification NNP cord-022053-idft1p6d 509 11 Assay Assay NNP cord-022053-idft1p6d 509 12 ( ( -LRB- cord-022053-idft1p6d 509 13 TB TB NNP cord-022053-idft1p6d 509 14 - - HYPH cord-022053-idft1p6d 509 15 LAMP LAMP NNP cord-022053-idft1p6d 509 16 ) ) -RRB- cord-022053-idft1p6d 509 17 for for IN cord-022053-idft1p6d 509 18 the the DT cord-022053-idft1p6d 509 19 Detection Detection NNP cord-022053-idft1p6d 509 20 of of IN cord-022053-idft1p6d 509 21 Tuberculosis Tuberculosis NNP cord-022053-idft1p6d 509 22 Clinical clinical JJ cord-022053-idft1p6d 509 23 evaluation evaluation NN cord-022053-idft1p6d 509 24 of of IN cord-022053-idft1p6d 509 25 a a DT cord-022053-idft1p6d 509 26 helicase helicase NN cord-022053-idft1p6d 509 27 - - HYPH cord-022053-idft1p6d 509 28 dependant dependant JJ cord-022053-idft1p6d 509 29 amplification amplification NN cord-022053-idft1p6d 509 30 ( ( -LRB- cord-022053-idft1p6d 509 31 HDA)-based hda)-based JJ cord-022053-idft1p6d 509 32 commercial commercial JJ cord-022053-idft1p6d 509 33 assay assay NN cord-022053-idft1p6d 509 34 for for IN cord-022053-idft1p6d 509 35 the the DT cord-022053-idft1p6d 509 36 simultaneous simultaneous JJ cord-022053-idft1p6d 509 37 detection detection NN cord-022053-idft1p6d 509 38 of of IN cord-022053-idft1p6d 509 39 HSV-1 hsv-1 NN cord-022053-idft1p6d 509 40 and and CC cord-022053-idft1p6d 509 41 HSV-2 HSV-2 NNP cord-022053-idft1p6d 509 42 Comparison comparison NN cord-022053-idft1p6d 509 43 of of IN cord-022053-idft1p6d 509 44 transcription transcription NN cord-022053-idft1p6d 509 45 mediated mediate VBN cord-022053-idft1p6d 509 46 amplification amplification NN cord-022053-idft1p6d 509 47 ( ( -LRB- cord-022053-idft1p6d 509 48 TMA TMA NNP cord-022053-idft1p6d 509 49 ) ) -RRB- cord-022053-idft1p6d 509 50 and and CC cord-022053-idft1p6d 509 51 reverse reverse VB cord-022053-idft1p6d 509 52 transcription transcription NN cord-022053-idft1p6d 509 53 polymerase polymerase NN cord-022053-idft1p6d 509 54 chain chain NN cord-022053-idft1p6d 509 55 reaction reaction NN cord-022053-idft1p6d 509 56 ( ( -LRB- cord-022053-idft1p6d 509 57 RT RT NNP cord-022053-idft1p6d 509 58 - - HYPH cord-022053-idft1p6d 509 59 PCR PCR NNP cord-022053-idft1p6d 509 60 ) ) -RRB- cord-022053-idft1p6d 509 61 for for IN cord-022053-idft1p6d 509 62 detection detection NN cord-022053-idft1p6d 509 63 of of IN cord-022053-idft1p6d 509 64 hepatitis hepatitis NN cord-022053-idft1p6d 509 65 C C NNP cord-022053-idft1p6d 509 66 virus virus NN cord-022053-idft1p6d 509 67 RNA RNA NNP cord-022053-idft1p6d 509 68 in in IN cord-022053-idft1p6d 509 69 liver liver NN cord-022053-idft1p6d 509 70 tissue tissue NN cord-022053-idft1p6d 510 1 Comparative comparative JJ cord-022053-idft1p6d 510 2 evaluation evaluation NN cord-022053-idft1p6d 510 3 of of IN cord-022053-idft1p6d 510 4 the the DT cord-022053-idft1p6d 510 5 Nanosphere Nanosphere NNP cord-022053-idft1p6d 510 6 Verigene Verigene NNP cord-022053-idft1p6d 510 7 RV+ RV+ NNP cord-022053-idft1p6d 510 8 assay assay NN cord-022053-idft1p6d 510 9 and and CC cord-022053-idft1p6d 510 10 the the DT cord-022053-idft1p6d 510 11 Simplexa Simplexa NNP cord-022053-idft1p6d 510 12 Flu Flu NNP cord-022053-idft1p6d 510 13 A A NNP cord-022053-idft1p6d 510 14 / / SYM cord-022053-idft1p6d 510 15 B B NNP cord-022053-idft1p6d 510 16 & & CC cord-022053-idft1p6d 510 17 RSV RSV NNP cord-022053-idft1p6d 510 18 kit kit NN cord-022053-idft1p6d 510 19 for for IN cord-022053-idft1p6d 510 20 detection detection NN cord-022053-idft1p6d 510 21 of of IN cord-022053-idft1p6d 510 22 influenza influenza NN cord-022053-idft1p6d 510 23 and and CC cord-022053-idft1p6d 510 24 respiratory respiratory JJ cord-022053-idft1p6d 510 25 syncytial syncytial JJ cord-022053-idft1p6d 510 26 viruses virus NNS cord-022053-idft1p6d 510 27 Evaluation Evaluation NNP cord-022053-idft1p6d 510 28 of of IN cord-022053-idft1p6d 510 29 the the DT cord-022053-idft1p6d 510 30 Verigene Verigene NNP cord-022053-idft1p6d 510 31 EP EP NNP cord-022053-idft1p6d 510 32 IUO IUO NNP cord-022053-idft1p6d 510 33 test test NN cord-022053-idft1p6d 510 34 for for IN cord-022053-idft1p6d 510 35 the the DT cord-022053-idft1p6d 510 36 rapid rapid JJ cord-022053-idft1p6d 510 37 detection detection NN cord-022053-idft1p6d 510 38 of of IN cord-022053-idft1p6d 510 39 bacterial bacterial JJ cord-022053-idft1p6d 510 40 and and CC cord-022053-idft1p6d 510 41 toxin toxin NN cord-022053-idft1p6d 510 42 causes cause NNS cord-022053-idft1p6d 510 43 of of IN cord-022053-idft1p6d 510 44 gastrointestinal gastrointestinal JJ cord-022053-idft1p6d 510 45 infection infection NN cord-022053-idft1p6d 510 46 Evaluation Evaluation NNP cord-022053-idft1p6d 510 47 of of IN cord-022053-idft1p6d 510 48 FilmArray FilmArray NNP cord-022053-idft1p6d 510 49 and and CC cord-022053-idft1p6d 510 50 Verigene Verigene NNP cord-022053-idft1p6d 510 51 systems system NNS cord-022053-idft1p6d 510 52 for for IN cord-022053-idft1p6d 510 53 rapid rapid JJ cord-022053-idft1p6d 510 54 identification identification NN cord-022053-idft1p6d 510 55 of of IN cord-022053-idft1p6d 510 56 positive positive JJ cord-022053-idft1p6d 510 57 blood blood NN cord-022053-idft1p6d 510 58 cultures culture NNS cord-022053-idft1p6d 510 59 Evaluation evaluation NN cord-022053-idft1p6d 510 60 and and CC cord-022053-idft1p6d 510 61 verification verification NN cord-022053-idft1p6d 510 62 of of IN cord-022053-idft1p6d 510 63 the the DT cord-022053-idft1p6d 510 64 nanosphere nanosphere JJ cord-022053-idft1p6d 510 65 Verigene Verigene NNP cord-022053-idft1p6d 510 66 RV+ RV+ NNP cord-022053-idft1p6d 510 67 assay assay NN cord-022053-idft1p6d 510 68 for for IN cord-022053-idft1p6d 510 69 detection detection NN cord-022053-idft1p6d 510 70 of of IN cord-022053-idft1p6d 510 71 influenza influenza NN cord-022053-idft1p6d 510 72 A a NN cord-022053-idft1p6d 510 73 / / SYM cord-022053-idft1p6d 510 74 B b NN cord-022053-idft1p6d 510 75 and and CC cord-022053-idft1p6d 510 76 H1 H1 NNP cord-022053-idft1p6d 510 77 / / SYM cord-022053-idft1p6d 510 78 H3 H3 NNP cord-022053-idft1p6d 511 1 subtyping subtyping NN cord-022053-idft1p6d 511 2 Principles principle NNS cord-022053-idft1p6d 511 3 of of IN cord-022053-idft1p6d 511 4 the the DT cord-022053-idft1p6d 511 5 xTAG xtag JJ cord-022053-idft1p6d 511 6 respiratory respiratory JJ cord-022053-idft1p6d 511 7 viral viral JJ cord-022053-idft1p6d 511 8 panel panel NN cord-022053-idft1p6d 511 9 assay assay NN cord-022053-idft1p6d 511 10 ( ( -LRB- cord-022053-idft1p6d 511 11 RVP RVP NNP cord-022053-idft1p6d 511 12 Assay Assay NNP cord-022053-idft1p6d 511 13 ) ) -RRB- cord-022053-idft1p6d 512 1 Clinical clinical JJ cord-022053-idft1p6d 512 2 evaluation evaluation NN cord-022053-idft1p6d 512 3 of of IN cord-022053-idft1p6d 512 4 the the DT cord-022053-idft1p6d 512 5 Luminex Luminex NNP cord-022053-idft1p6d 512 6 NxTAG NxTAG NNP cord-022053-idft1p6d 512 7 respiratory respiratory JJ cord-022053-idft1p6d 512 8 pathogen pathogen NN cord-022053-idft1p6d 512 9 panel panel NN cord-022053-idft1p6d 512 10 Comparison comparison NN cord-022053-idft1p6d 512 11 of of IN cord-022053-idft1p6d 512 12 the the DT cord-022053-idft1p6d 512 13 conventional conventional JJ cord-022053-idft1p6d 512 14 multiplex multiplex NN cord-022053-idft1p6d 512 15 RT RT NNP cord-022053-idft1p6d 512 16 - - HYPH cord-022053-idft1p6d 512 17 PCR PCR NNP cord-022053-idft1p6d 512 18 , , , cord-022053-idft1p6d 512 19 real real JJ cord-022053-idft1p6d 512 20 time time NN cord-022053-idft1p6d 512 21 RT RT NNP cord-022053-idft1p6d 512 22 - - HYPH cord-022053-idft1p6d 512 23 PCR PCR NNP cord-022053-idft1p6d 512 24 and and CC cord-022053-idft1p6d 512 25 Luminex Luminex NNP cord-022053-idft1p6d 512 26 xTAG(R xTAG(R NNP cord-022053-idft1p6d 512 27 ) ) -RRB- cord-022053-idft1p6d 513 1 RVP RVP NNP cord-022053-idft1p6d 513 2 fast fast JJ cord-022053-idft1p6d 513 3 assay assay NN cord-022053-idft1p6d 513 4 for for IN cord-022053-idft1p6d 513 5 the the DT cord-022053-idft1p6d 513 6 detection detection NN cord-022053-idft1p6d 513 7 of of IN cord-022053-idft1p6d 513 8 respiratory respiratory JJ cord-022053-idft1p6d 513 9 viruses virus NNS cord-022053-idft1p6d 513 10 Comparison comparison NN cord-022053-idft1p6d 513 11 of of IN cord-022053-idft1p6d 513 12 the the DT cord-022053-idft1p6d 513 13 Biofire Biofire NNP cord-022053-idft1p6d 513 14 FilmArray FilmArray NNP cord-022053-idft1p6d 513 15 RP RP NNP cord-022053-idft1p6d 513 16 , , , cord-022053-idft1p6d 513 17 Genmark Genmark NNP cord-022053-idft1p6d 513 18 eSensor eSensor NNP cord-022053-idft1p6d 513 19 RVP RVP NNP cord-022053-idft1p6d 513 20 , , , cord-022053-idft1p6d 513 21 Luminex Luminex NNP cord-022053-idft1p6d 513 22 xTAG xTAG VBD cord-022053-idft1p6d 513 23 RVPv1 RVPv1 NNP cord-022053-idft1p6d 513 24 , , , cord-022053-idft1p6d 513 25 and and CC cord-022053-idft1p6d 513 26 Luminex Luminex NNP cord-022053-idft1p6d 513 27 xTAG xTAG VBD cord-022053-idft1p6d 513 28 RVP RVP NNP cord-022053-idft1p6d 513 29 fast fast JJ cord-022053-idft1p6d 513 30 multiplex multiplex JJ cord-022053-idft1p6d 513 31 assays assay NNS cord-022053-idft1p6d 513 32 for for IN cord-022053-idft1p6d 513 33 detection detection NN cord-022053-idft1p6d 513 34 of of IN cord-022053-idft1p6d 513 35 respiratory respiratory JJ cord-022053-idft1p6d 513 36 viruses virus NNS cord-022053-idft1p6d 513 37 Phylogenetic phylogenetic JJ cord-022053-idft1p6d 513 38 structure structure NN cord-022053-idft1p6d 513 39 of of IN cord-022053-idft1p6d 513 40 the the DT cord-022053-idft1p6d 513 41 prokaryotic prokaryotic JJ cord-022053-idft1p6d 513 42 domain domain NN cord-022053-idft1p6d 513 43 : : : cord-022053-idft1p6d 513 44 the the DT cord-022053-idft1p6d 513 45 primary primary JJ cord-022053-idft1p6d 513 46 kingdoms kingdom NNS cord-022053-idft1p6d 513 47 Then then RB cord-022053-idft1p6d 513 48 and and CC cord-022053-idft1p6d 513 49 now now RB cord-022053-idft1p6d 513 50 : : : cord-022053-idft1p6d 513 51 use use NN cord-022053-idft1p6d 513 52 of of IN cord-022053-idft1p6d 513 53 16S 16S NNP cord-022053-idft1p6d 513 54 rDNA rDNA NNP cord-022053-idft1p6d 513 55 gene gene NN cord-022053-idft1p6d 513 56 sequencing sequencing NN cord-022053-idft1p6d 513 57 for for IN cord-022053-idft1p6d 513 58 bacterial bacterial JJ cord-022053-idft1p6d 513 59 identification identification NN cord-022053-idft1p6d 513 60 and and CC cord-022053-idft1p6d 513 61 discovery discovery NN cord-022053-idft1p6d 513 62 of of IN cord-022053-idft1p6d 513 63 novel novel JJ cord-022053-idft1p6d 513 64 bacteria bacteria NNS cord-022053-idft1p6d 513 65 in in IN cord-022053-idft1p6d 513 66 clinical clinical JJ cord-022053-idft1p6d 513 67 microbiology microbiology NN cord-022053-idft1p6d 513 68 laboratories laboratories NNPS cord-022053-idft1p6d 513 69 Report Report NNP cord-022053-idft1p6d 513 70 of of IN cord-022053-idft1p6d 513 71 the the DT cord-022053-idft1p6d 513 72 ad ad FW cord-022053-idft1p6d 513 73 hoc hoc FW cord-022053-idft1p6d 513 74 committee committee NNP cord-022053-idft1p6d 513 75 for for IN cord-022053-idft1p6d 513 76 the the DT cord-022053-idft1p6d 513 77 re re NN cord-022053-idft1p6d 513 78 - - NN cord-022053-idft1p6d 513 79 evaluation evaluation NN cord-022053-idft1p6d 513 80 of of IN cord-022053-idft1p6d 513 81 the the DT cord-022053-idft1p6d 513 82 species specie NNS cord-022053-idft1p6d 513 83 definition definition NN cord-022053-idft1p6d 513 84 in in IN cord-022053-idft1p6d 513 85 bacteriology bacteriology NNP cord-022053-idft1p6d 513 86 Interpretive Interpretive NNP cord-022053-idft1p6d 513 87 Criteria Criteria NNP cord-022053-idft1p6d 513 88 for for IN cord-022053-idft1p6d 513 89 Identification identification NN cord-022053-idft1p6d 513 90 of of IN cord-022053-idft1p6d 513 91 Bacteria Bacteria NNS cord-022053-idft1p6d 513 92 and and CC cord-022053-idft1p6d 513 93 Fungi fungus NNS cord-022053-idft1p6d 513 94 by by IN cord-022053-idft1p6d 513 95 DNA DNA NNP cord-022053-idft1p6d 513 96 Target Target NNP cord-022053-idft1p6d 513 97 Sequencing Sequencing NNP cord-022053-idft1p6d 513 98 ; ; : cord-022053-idft1p6d 513 99 Approved Approved NNP cord-022053-idft1p6d 513 100 Guideline Guideline NNP cord-022053-idft1p6d 513 101 Broad Broad NNP cord-022053-idft1p6d 513 102 - - HYPH cord-022053-idft1p6d 513 103 range range NN cord-022053-idft1p6d 513 104 16S 16S NNPS cord-022053-idft1p6d 513 105 rRNA rrna NN cord-022053-idft1p6d 513 106 gene gene NN cord-022053-idft1p6d 513 107 polymerase polymerase NN cord-022053-idft1p6d 513 108 chain chain NN cord-022053-idft1p6d 513 109 reaction reaction NN cord-022053-idft1p6d 513 110 for for IN cord-022053-idft1p6d 513 111 diagnosis diagnosis NN cord-022053-idft1p6d 513 112 of of IN cord-022053-idft1p6d 513 113 culturenegative culturenegative JJ cord-022053-idft1p6d 513 114 bacterial bacterial JJ cord-022053-idft1p6d 513 115 infections infection NNS cord-022053-idft1p6d 513 116 Utility Utility NNP cord-022053-idft1p6d 513 117 of of IN cord-022053-idft1p6d 513 118 16S 16S NNP cord-022053-idft1p6d 513 119 rDNA rdna NN cord-022053-idft1p6d 513 120 sequencing sequencing NN cord-022053-idft1p6d 513 121 for for IN cord-022053-idft1p6d 513 122 identification identification NN cord-022053-idft1p6d 513 123 of of IN cord-022053-idft1p6d 513 124 rare rare JJ cord-022053-idft1p6d 513 125 pathogenic pathogenic JJ cord-022053-idft1p6d 513 126 bacteria bacteria NNS cord-022053-idft1p6d 513 127 Identification identification NN cord-022053-idft1p6d 513 128 of of IN cord-022053-idft1p6d 513 129 bacteria bacteria NNS cord-022053-idft1p6d 513 130 in in IN cord-022053-idft1p6d 513 131 formalin formalin NN cord-022053-idft1p6d 513 132 - - HYPH cord-022053-idft1p6d 513 133 fixed fix VBN cord-022053-idft1p6d 513 134 , , , cord-022053-idft1p6d 513 135 paraffin paraffin NN cord-022053-idft1p6d 513 136 - - HYPH cord-022053-idft1p6d 513 137 embedded embed VBN cord-022053-idft1p6d 513 138 heart heart NN cord-022053-idft1p6d 513 139 valve valve NN cord-022053-idft1p6d 513 140 tissue tissue NN cord-022053-idft1p6d 513 141 via via IN cord-022053-idft1p6d 513 142 16S 16S NNP cord-022053-idft1p6d 513 143 rRNA rrna NN cord-022053-idft1p6d 513 144 gene gene NN cord-022053-idft1p6d 513 145 nucleotide nucleotide JJ cord-022053-idft1p6d 513 146 sequencing sequencing NN cord-022053-idft1p6d 513 147 16S 16S NNP cord-022053-idft1p6d 513 148 rRNA rrna NN cord-022053-idft1p6d 513 149 sequencing sequencing NN cord-022053-idft1p6d 513 150 in in IN cord-022053-idft1p6d 513 151 routine routine JJ cord-022053-idft1p6d 513 152 bacterial bacterial JJ cord-022053-idft1p6d 513 153 identification identification NN cord-022053-idft1p6d 513 154 : : : cord-022053-idft1p6d 513 155 a a DT cord-022053-idft1p6d 513 156 30-month 30-month CD cord-022053-idft1p6d 513 157 experiment experiment NN cord-022053-idft1p6d 513 158 Improved improve VBN cord-022053-idft1p6d 513 159 diagnosis diagnosis NN cord-022053-idft1p6d 513 160 of of IN cord-022053-idft1p6d 513 161 mycobacterial mycobacterial JJ cord-022053-idft1p6d 513 162 infections infection NNS cord-022053-idft1p6d 513 163 in in IN cord-022053-idft1p6d 513 164 formalin formalin NN cord-022053-idft1p6d 513 165 - - HYPH cord-022053-idft1p6d 513 166 fixed fix VBN cord-022053-idft1p6d 513 167 and and CC cord-022053-idft1p6d 513 168 paraffin paraffin NN cord-022053-idft1p6d 513 169 - - HYPH cord-022053-idft1p6d 513 170 embedded embed VBN cord-022053-idft1p6d 513 171 sections section NNS cord-022053-idft1p6d 513 172 with with IN cord-022053-idft1p6d 513 173 nested nested JJ cord-022053-idft1p6d 513 174 polymerase polymerase NN cord-022053-idft1p6d 513 175 chain chain NN cord-022053-idft1p6d 513 176 reaction reaction NN cord-022053-idft1p6d 513 177 Rapid Rapid NNP cord-022053-idft1p6d 513 178 real real JJ cord-022053-idft1p6d 513 179 - - HYPH cord-022053-idft1p6d 513 180 time time NN cord-022053-idft1p6d 513 181 PCR pcr NN cord-022053-idft1p6d 513 182 for for IN cord-022053-idft1p6d 513 183 detection detection NN cord-022053-idft1p6d 513 184 of of IN cord-022053-idft1p6d 513 185 Mycobacterium Mycobacterium NNP cord-022053-idft1p6d 513 186 tuberculosis tuberculosis NN cord-022053-idft1p6d 513 187 complex complex JJ cord-022053-idft1p6d 513 188 DNA dna NN cord-022053-idft1p6d 513 189 in in IN cord-022053-idft1p6d 513 190 formalin formalin NN cord-022053-idft1p6d 513 191 - - HYPH cord-022053-idft1p6d 513 192 fixed fix VBN cord-022053-idft1p6d 513 193 paraffin paraffin NN cord-022053-idft1p6d 513 194 embedded embed VBN cord-022053-idft1p6d 513 195 tissues tissue NNS cord-022053-idft1p6d 513 196 : : : cord-022053-idft1p6d 514 1 16 16 CD cord-022053-idft1p6d 514 2 % % NN cord-022053-idft1p6d 514 3 of of IN cord-022053-idft1p6d 514 4 histological histological JJ cord-022053-idft1p6d 514 5 ' ' `` cord-022053-idft1p6d 514 6 sarcoid sarcoid NN cord-022053-idft1p6d 514 7 ' ' '' cord-022053-idft1p6d 514 8 may may MD cord-022053-idft1p6d 514 9 contain contain VB cord-022053-idft1p6d 514 10 such such JJ cord-022053-idft1p6d 514 11 DNA DNA NNP cord-022053-idft1p6d 514 12 Broad Broad NNP cord-022053-idft1p6d 514 13 - - HYPH cord-022053-idft1p6d 514 14 range range NN cord-022053-idft1p6d 514 15 PCR PCR NNP cord-022053-idft1p6d 514 16 and and CC cord-022053-idft1p6d 514 17 sequencing sequencing NN cord-022053-idft1p6d 514 18 in in IN cord-022053-idft1p6d 514 19 routine routine JJ cord-022053-idft1p6d 514 20 diagnosis diagnosis NN cord-022053-idft1p6d 514 21 of of IN cord-022053-idft1p6d 514 22 infective infective JJ cord-022053-idft1p6d 514 23 endocarditis endocarditis NN cord-022053-idft1p6d 514 24 Duration duration NN cord-022053-idft1p6d 514 25 of of IN cord-022053-idft1p6d 514 26 hypotension hypotension NN cord-022053-idft1p6d 514 27 before before IN cord-022053-idft1p6d 514 28 initiation initiation NN cord-022053-idft1p6d 514 29 of of IN cord-022053-idft1p6d 514 30 effective effective JJ cord-022053-idft1p6d 514 31 antimicrobial antimicrobial JJ cord-022053-idft1p6d 514 32 therapy therapy NN cord-022053-idft1p6d 514 33 is be VBZ cord-022053-idft1p6d 514 34 the the DT cord-022053-idft1p6d 514 35 critical critical JJ cord-022053-idft1p6d 514 36 determinant determinant NN cord-022053-idft1p6d 514 37 of of IN cord-022053-idft1p6d 514 38 survival survival NN cord-022053-idft1p6d 514 39 in in IN cord-022053-idft1p6d 514 40 human human JJ cord-022053-idft1p6d 514 41 septic septic JJ cord-022053-idft1p6d 514 42 shock shock NN cord-022053-idft1p6d 514 43 Emerging Emerging NNP cord-022053-idft1p6d 514 44 technologies technology NNS cord-022053-idft1p6d 514 45 for for IN cord-022053-idft1p6d 514 46 rapid rapid JJ cord-022053-idft1p6d 514 47 identification identification NN cord-022053-idft1p6d 514 48 of of IN cord-022053-idft1p6d 514 49 bloodstream bloodstream NN cord-022053-idft1p6d 514 50 pathogens pathogen NNS cord-022053-idft1p6d 514 51 ID ID NNP cord-022053-idft1p6d 514 52 learning learn VBG cord-022053-idft1p6d 514 53 unit unit NN cord-022053-idft1p6d 514 54 - - HYPH cord-022053-idft1p6d 514 55 diagnostics diagnostic NNS cord-022053-idft1p6d 514 56 update update NN cord-022053-idft1p6d 514 57 : : : cord-022053-idft1p6d 514 58 current current JJ cord-022053-idft1p6d 514 59 laboratory laboratory NN cord-022053-idft1p6d 514 60 methods method NNS cord-022053-idft1p6d 514 61 for for IN cord-022053-idft1p6d 514 62 rapid rapid JJ cord-022053-idft1p6d 514 63 pathogen pathogen NN cord-022053-idft1p6d 514 64 identification identification NN cord-022053-idft1p6d 514 65 in in IN cord-022053-idft1p6d 514 66 patients patient NNS cord-022053-idft1p6d 514 67 with with IN cord-022053-idft1p6d 514 68 bloodstream bloodstream NN cord-022053-idft1p6d 514 69 infections infection NNS cord-022053-idft1p6d 514 70 Nonculture Nonculture NNP cord-022053-idft1p6d 514 71 techniques technique NNS cord-022053-idft1p6d 514 72 for for IN cord-022053-idft1p6d 514 73 the the DT cord-022053-idft1p6d 514 74 detection detection NN cord-022053-idft1p6d 514 75 of of IN cord-022053-idft1p6d 514 76 bacteremia bacteremia NN cord-022053-idft1p6d 514 77 and and CC cord-022053-idft1p6d 514 78 fungemia fungemia NN cord-022053-idft1p6d 514 79 an an DT cord-022053-idft1p6d 514 80 automated automate VBN cord-022053-idft1p6d 514 81 nested nested JJ cord-022053-idft1p6d 514 82 multiplex multiplex NN cord-022053-idft1p6d 514 83 PCR pcr NN cord-022053-idft1p6d 514 84 system system NN cord-022053-idft1p6d 514 85 for for IN cord-022053-idft1p6d 514 86 multi multi JJ cord-022053-idft1p6d 514 87 - - JJ cord-022053-idft1p6d 514 88 pathogen pathogen NN cord-022053-idft1p6d 514 89 detection detection NN cord-022053-idft1p6d 514 90 : : : cord-022053-idft1p6d 514 91 development development NN cord-022053-idft1p6d 514 92 and and CC cord-022053-idft1p6d 514 93 application application NN cord-022053-idft1p6d 514 94 to to IN cord-022053-idft1p6d 514 95 respiratory respiratory JJ cord-022053-idft1p6d 514 96 tract tract NN cord-022053-idft1p6d 514 97 infection infection NN cord-022053-idft1p6d 515 1 Multicenter multicenter JJ cord-022053-idft1p6d 515 2 evaluation evaluation NN cord-022053-idft1p6d 515 3 of of IN cord-022053-idft1p6d 515 4 the the DT cord-022053-idft1p6d 515 5 BioFire BioFire NNP cord-022053-idft1p6d 515 6 FilmArray FilmArray NNP cord-022053-idft1p6d 515 7 gastrointestinal gastrointestinal JJ cord-022053-idft1p6d 515 8 panel panel NN cord-022053-idft1p6d 515 9 for for IN cord-022053-idft1p6d 515 10 etiologic etiologic JJ cord-022053-idft1p6d 515 11 diagnosis diagnosis NN cord-022053-idft1p6d 515 12 of of IN cord-022053-idft1p6d 515 13 infectious infectious JJ cord-022053-idft1p6d 515 14 gastroenteritis gastroenteritis NN cord-022053-idft1p6d 516 1 Comparative comparative JJ cord-022053-idft1p6d 516 2 evaluation evaluation NN cord-022053-idft1p6d 516 3 of of IN cord-022053-idft1p6d 516 4 two two CD cord-022053-idft1p6d 516 5 commercial commercial JJ cord-022053-idft1p6d 516 6 multiplex multiplex NN cord-022053-idft1p6d 516 7 panels panel NNS cord-022053-idft1p6d 516 8 for for IN cord-022053-idft1p6d 516 9 detection detection NN cord-022053-idft1p6d 516 10 of of IN cord-022053-idft1p6d 516 11 gastrointestinal gastrointestinal JJ cord-022053-idft1p6d 516 12 pathogens pathogen NNS cord-022053-idft1p6d 516 13 by by IN cord-022053-idft1p6d 516 14 use use NN cord-022053-idft1p6d 516 15 of of IN cord-022053-idft1p6d 516 16 clinical clinical JJ cord-022053-idft1p6d 516 17 stool stool NN cord-022053-idft1p6d 516 18 specimens specimen NNS cord-022053-idft1p6d 516 19 Spectrum Spectrum NNP cord-022053-idft1p6d 516 20 of of IN cord-022053-idft1p6d 516 21 enteropathogens enteropathogen NNS cord-022053-idft1p6d 516 22 detected detect VBN cord-022053-idft1p6d 516 23 by by IN cord-022053-idft1p6d 516 24 the the DT cord-022053-idft1p6d 516 25 FilmArray FilmArray NNP cord-022053-idft1p6d 516 26 GI GI NNP cord-022053-idft1p6d 516 27 panel panel NN cord-022053-idft1p6d 516 28 in in IN cord-022053-idft1p6d 516 29 a a DT cord-022053-idft1p6d 516 30 multicentre multicentre NNP cord-022053-idft1p6d 516 31 study study NN cord-022053-idft1p6d 516 32 of of IN cord-022053-idft1p6d 516 33 community community NN cord-022053-idft1p6d 516 34 - - HYPH cord-022053-idft1p6d 516 35 acquired acquire VBN cord-022053-idft1p6d 516 36 gastroenteritis gastroenteritis JJ cord-022053-idft1p6d 516 37 Multi multi JJ cord-022053-idft1p6d 516 38 - - JJ cord-022053-idft1p6d 516 39 center center JJ cord-022053-idft1p6d 516 40 clinical clinical JJ cord-022053-idft1p6d 516 41 evaluation evaluation NN cord-022053-idft1p6d 516 42 of of IN cord-022053-idft1p6d 516 43 a a DT cord-022053-idft1p6d 516 44 multiplex multiplex JJ cord-022053-idft1p6d 516 45 meningitis meningitis NN cord-022053-idft1p6d 516 46 / / , cord-022053-idft1p6d 516 47 encephalitis encephalitis RB cord-022053-idft1p6d 516 48 PCR PCR NNP cord-022053-idft1p6d 516 49 panel panel NN cord-022053-idft1p6d 516 50 for for IN cord-022053-idft1p6d 516 51 simultaneous simultaneous JJ cord-022053-idft1p6d 516 52 detection detection NN cord-022053-idft1p6d 516 53 of of IN cord-022053-idft1p6d 516 54 bacteria bacteria NNS cord-022053-idft1p6d 516 55 , , , cord-022053-idft1p6d 516 56 yeasts yeast NNS cord-022053-idft1p6d 516 57 and and CC cord-022053-idft1p6d 516 58 viruses virus NNS cord-022053-idft1p6d 516 59 in in IN cord-022053-idft1p6d 516 60 cerebrospinal cerebrospinal JJ cord-022053-idft1p6d 516 61 fluid fluid NN cord-022053-idft1p6d 516 62 specimens specimen NNS cord-022053-idft1p6d 516 63 General General NNP cord-022053-idft1p6d 516 64 Meeting Meeting NNP cord-022053-idft1p6d 516 65 Enhancing enhance VBG cord-022053-idft1p6d 516 66 pathogen pathogen NN cord-022053-idft1p6d 516 67 identification identification NN cord-022053-idft1p6d 516 68 in in IN cord-022053-idft1p6d 516 69 patients patient NNS cord-022053-idft1p6d 516 70 with with IN cord-022053-idft1p6d 516 71 meningitis meningitis NN cord-022053-idft1p6d 516 72 and and CC cord-022053-idft1p6d 516 73 a a DT cord-022053-idft1p6d 516 74 negative negative JJ cord-022053-idft1p6d 516 75 Gram gram NN cord-022053-idft1p6d 516 76 stain stain NN cord-022053-idft1p6d 516 77 using use VBG cord-022053-idft1p6d 517 1 the the DT cord-022053-idft1p6d 517 2 BioFire BioFire NNP cord-022053-idft1p6d 517 3 FilmArray((R FilmArray((R NNPS cord-022053-idft1p6d 517 4 ) ) -RRB- cord-022053-idft1p6d 517 5 ) ) -RRB- cord-022053-idft1p6d 517 6 meningitis/ meningitis/ CD cord-022053-idft1p6d 517 7 encephalitis encephalitis RB cord-022053-idft1p6d 517 8 panel panel NN cord-022053-idft1p6d 517 9 Performance performance NN cord-022053-idft1p6d 517 10 evaluation evaluation NN cord-022053-idft1p6d 517 11 of of IN cord-022053-idft1p6d 517 12 the the DT cord-022053-idft1p6d 517 13 Verigene(R verigene(r NN cord-022053-idft1p6d 517 14 ) ) -RRB- cord-022053-idft1p6d 518 1 ( ( -LRB- cord-022053-idft1p6d 518 2 Nanosphere Nanosphere NNP cord-022053-idft1p6d 518 3 ) ) -RRB- cord-022053-idft1p6d 518 4 and and CC cord-022053-idft1p6d 518 5 FilmArray(R filmarray(r ADD cord-022053-idft1p6d 518 6 ) ) -RRB- cord-022053-idft1p6d 519 1 ( ( -LRB- cord-022053-idft1p6d 519 2 BioFire(R BioFire(R NNP cord-022053-idft1p6d 519 3 ) ) -RRB- cord-022053-idft1p6d 519 4 ) ) -RRB- cord-022053-idft1p6d 520 1 molecular molecular JJ cord-022053-idft1p6d 520 2 assays assay NNS cord-022053-idft1p6d 520 3 for for IN cord-022053-idft1p6d 520 4 identification identification NN cord-022053-idft1p6d 520 5 of of IN cord-022053-idft1p6d 520 6 causative causative JJ cord-022053-idft1p6d 520 7 organisms organism NNS cord-022053-idft1p6d 520 8 in in IN cord-022053-idft1p6d 520 9 bacterial bacterial JJ cord-022053-idft1p6d 520 10 bloodstream bloodstream NN cord-022053-idft1p6d 520 11 infections infection NNS cord-022053-idft1p6d 521 1 Clinical clinical JJ cord-022053-idft1p6d 521 2 evaluation evaluation NN cord-022053-idft1p6d 521 3 of of IN cord-022053-idft1p6d 521 4 the the DT cord-022053-idft1p6d 521 5 FilmArray FilmArray NNP cord-022053-idft1p6d 521 6 blood blood NN cord-022053-idft1p6d 521 7 culture culture NN cord-022053-idft1p6d 521 8 identification identification NN cord-022053-idft1p6d 521 9 panel panel NN cord-022053-idft1p6d 521 10 in in IN cord-022053-idft1p6d 521 11 identification identification NN cord-022053-idft1p6d 521 12 of of IN cord-022053-idft1p6d 521 13 bacteria bacteria NNS cord-022053-idft1p6d 521 14 and and CC cord-022053-idft1p6d 521 15 yeasts yeast NNS cord-022053-idft1p6d 521 16 from from IN cord-022053-idft1p6d 521 17 positive positive JJ cord-022053-idft1p6d 521 18 blood blood NN cord-022053-idft1p6d 521 19 culture culture NN cord-022053-idft1p6d 521 20 bottles bottle NNS cord-022053-idft1p6d 522 1 Multicenter multicenter JJ cord-022053-idft1p6d 522 2 evaluation evaluation NN cord-022053-idft1p6d 522 3 of of IN cord-022053-idft1p6d 522 4 the the DT cord-022053-idft1p6d 522 5 BD BD NNP cord-022053-idft1p6d 522 6 max max NNP cord-022053-idft1p6d 522 7 enteric enteric JJ cord-022053-idft1p6d 522 8 bacterial bacterial JJ cord-022053-idft1p6d 522 9 panel panel NN cord-022053-idft1p6d 522 10 PCR PCR NNP cord-022053-idft1p6d 522 11 assay assay NN cord-022053-idft1p6d 522 12 for for IN cord-022053-idft1p6d 522 13 rapid rapid JJ cord-022053-idft1p6d 522 14 detection detection NN cord-022053-idft1p6d 522 15 of of IN cord-022053-idft1p6d 522 16 Salmonella Salmonella NNP cord-022053-idft1p6d 522 17 spp spp NNP cord-022053-idft1p6d 522 18 . . . cord-022053-idft1p6d 523 1 , , , cord-022053-idft1p6d 523 2 Shigella Shigella NNP cord-022053-idft1p6d 523 3 spp spp NNS cord-022053-idft1p6d 523 4 . . . cord-022053-idft1p6d 524 1 , , , cord-022053-idft1p6d 524 2 Campylobacter Campylobacter NNP cord-022053-idft1p6d 524 3 spp spp NNS cord-022053-idft1p6d 524 4 . . . cord-022053-idft1p6d 525 1 ( ( -LRB- cord-022053-idft1p6d 525 2 C. C. NNP cord-022053-idft1p6d 525 3 jejuni jejuni NNP cord-022053-idft1p6d 525 4 and and CC cord-022053-idft1p6d 525 5 C. C. NNP cord-022053-idft1p6d 525 6 coli coli NNS cord-022053-idft1p6d 525 7 ) ) -RRB- cord-022053-idft1p6d 525 8 , , , cord-022053-idft1p6d 525 9 and and CC cord-022053-idft1p6d 525 10 Shiga Shiga NNP cord-022053-idft1p6d 525 11 toxin toxin NN cord-022053-idft1p6d 526 1 1 1 CD cord-022053-idft1p6d 526 2 and and CC cord-022053-idft1p6d 526 3 2 2 CD cord-022053-idft1p6d 526 4 genes gene NNS cord-022053-idft1p6d 526 5 Comparison comparison NN cord-022053-idft1p6d 526 6 of of IN cord-022053-idft1p6d 526 7 the the DT cord-022053-idft1p6d 526 8 BD BD NNP cord-022053-idft1p6d 526 9 MAX MAX NNP cord-022053-idft1p6d 526 10 enteric enteric JJ cord-022053-idft1p6d 526 11 bacterial bacterial JJ cord-022053-idft1p6d 526 12 panel panel NN cord-022053-idft1p6d 526 13 to to IN cord-022053-idft1p6d 526 14 routine routine JJ cord-022053-idft1p6d 526 15 culture culture NN cord-022053-idft1p6d 526 16 methods method NNS cord-022053-idft1p6d 526 17 for for IN cord-022053-idft1p6d 526 18 detection detection NN cord-022053-idft1p6d 526 19 of of IN cord-022053-idft1p6d 526 20 Campylobacter Campylobacter NNP cord-022053-idft1p6d 526 21 , , , cord-022053-idft1p6d 526 22 enterohemorrhagic enterohemorrhagic JJ cord-022053-idft1p6d 526 23 Escherichia escherichia NN cord-022053-idft1p6d 526 24 coli coli NNS cord-022053-idft1p6d 526 25 ( ( -LRB- cord-022053-idft1p6d 526 26 O157 O157 NNP cord-022053-idft1p6d 526 27 ) ) -RRB- cord-022053-idft1p6d 526 28 , , , cord-022053-idft1p6d 526 29 Salmonella Salmonella NNP cord-022053-idft1p6d 526 30 , , , cord-022053-idft1p6d 526 31 and and CC cord-022053-idft1p6d 526 32 Shigella Shigella NNP cord-022053-idft1p6d 526 33 isolates isolate VBZ cord-022053-idft1p6d 526 34 in in IN cord-022053-idft1p6d 526 35 preserved preserve VBN cord-022053-idft1p6d 526 36 stool stool NN cord-022053-idft1p6d 526 37 specimens specimen NNS cord-022053-idft1p6d 526 38 Comparison comparison NN cord-022053-idft1p6d 526 39 of of IN cord-022053-idft1p6d 526 40 the the DT cord-022053-idft1p6d 526 41 BD BD NNP cord-022053-idft1p6d 526 42 MAX(R max(r CD cord-022053-idft1p6d 526 43 ) ) -RRB- cord-022053-idft1p6d 526 44 enteric enteric JJ cord-022053-idft1p6d 526 45 bacterial bacterial JJ cord-022053-idft1p6d 526 46 panel panel NN cord-022053-idft1p6d 526 47 assay assay NN cord-022053-idft1p6d 526 48 with with IN cord-022053-idft1p6d 526 49 conventional conventional JJ cord-022053-idft1p6d 526 50 diagnostic diagnostic JJ cord-022053-idft1p6d 526 51 procedures procedure NNS cord-022053-idft1p6d 526 52 in in IN cord-022053-idft1p6d 526 53 diarrheal diarrheal JJ cord-022053-idft1p6d 526 54 stool stool NN cord-022053-idft1p6d 526 55 samples sample NNS cord-022053-idft1p6d 526 56 Evaluation Evaluation NNP cord-022053-idft1p6d 526 57 of of IN cord-022053-idft1p6d 526 58 the the DT cord-022053-idft1p6d 526 59 BD BD NNP cord-022053-idft1p6d 526 60 Max Max NNP cord-022053-idft1p6d 526 61 enteric enteric JJ cord-022053-idft1p6d 526 62 parasite parasite NN cord-022053-idft1p6d 526 63 panel panel NN cord-022053-idft1p6d 526 64 for for IN cord-022053-idft1p6d 526 65 clinical clinical JJ cord-022053-idft1p6d 526 66 diagnostics diagnostic NNS cord-022053-idft1p6d 526 67 Comparison comparison NN cord-022053-idft1p6d 526 68 of of IN cord-022053-idft1p6d 526 69 three three CD cord-022053-idft1p6d 526 70 commercial commercial JJ cord-022053-idft1p6d 526 71 RT RT NNP cord-022053-idft1p6d 526 72 - - HYPH cord-022053-idft1p6d 526 73 PCR PCR NNP cord-022053-idft1p6d 526 74 systems system NNS cord-022053-idft1p6d 526 75 for for IN cord-022053-idft1p6d 526 76 the the DT cord-022053-idft1p6d 526 77 detection detection NN cord-022053-idft1p6d 526 78 of of IN cord-022053-idft1p6d 526 79 respiratory respiratory JJ cord-022053-idft1p6d 526 80 viruses virus NNS cord-022053-idft1p6d 526 81 Next next JJ cord-022053-idft1p6d 526 82 - - HYPH cord-022053-idft1p6d 526 83 generation generation NN cord-022053-idft1p6d 526 84 sequencing sequencing NN cord-022053-idft1p6d 526 85 for for IN cord-022053-idft1p6d 526 86 infectious infectious JJ cord-022053-idft1p6d 526 87 disease disease NN cord-022053-idft1p6d 526 88 diagnosis diagnosis NN cord-022053-idft1p6d 526 89 and and CC cord-022053-idft1p6d 526 90 management management NN cord-022053-idft1p6d 526 91 : : : cord-022053-idft1p6d 526 92 a a DT cord-022053-idft1p6d 526 93 report report NN cord-022053-idft1p6d 526 94 of of IN cord-022053-idft1p6d 526 95 the the DT cord-022053-idft1p6d 526 96 Association Association NNP cord-022053-idft1p6d 526 97 for for IN cord-022053-idft1p6d 526 98 Molecular Molecular NNP cord-022053-idft1p6d 526 99 Pathology Pathology NNP cord-022053-idft1p6d 526 100 Clinical clinical JJ cord-022053-idft1p6d 526 101 detection detection NN cord-022053-idft1p6d 526 102 and and CC cord-022053-idft1p6d 526 103 characterization characterization NN cord-022053-idft1p6d 526 104 of of IN cord-022053-idft1p6d 526 105 bacterial bacterial JJ cord-022053-idft1p6d 526 106 pathogens pathogen NNS cord-022053-idft1p6d 526 107 in in IN cord-022053-idft1p6d 526 108 the the DT cord-022053-idft1p6d 526 109 genomics genomic NNS cord-022053-idft1p6d 526 110 era era NN cord-022053-idft1p6d 526 111 Routine routine JJ cord-022053-idft1p6d 526 112 use use NN cord-022053-idft1p6d 526 113 of of IN cord-022053-idft1p6d 526 114 microbial microbial JJ cord-022053-idft1p6d 526 115 whole whole JJ cord-022053-idft1p6d 526 116 genome genome NN cord-022053-idft1p6d 526 117 sequencing sequencing NN cord-022053-idft1p6d 526 118 in in IN cord-022053-idft1p6d 526 119 diagnostic diagnostic JJ cord-022053-idft1p6d 526 120 and and CC cord-022053-idft1p6d 526 121 public public JJ cord-022053-idft1p6d 526 122 health health NN cord-022053-idft1p6d 526 123 microbiology microbiology NN cord-022053-idft1p6d 526 124 Tracking track VBG cord-022053-idft1p6d 526 125 a a DT cord-022053-idft1p6d 526 126 hospital hospital NN cord-022053-idft1p6d 526 127 outbreak outbreak NN cord-022053-idft1p6d 526 128 of of IN cord-022053-idft1p6d 526 129 carbapenem carbapenem JJ cord-022053-idft1p6d 526 130 - - HYPH cord-022053-idft1p6d 526 131 resistant resistant JJ cord-022053-idft1p6d 526 132 Klebsiella Klebsiella NNP cord-022053-idft1p6d 526 133 pneumoniae pneumoniae NN cord-022053-idft1p6d 526 134 with with IN cord-022053-idft1p6d 526 135 whole whole JJ cord-022053-idft1p6d 526 136 - - HYPH cord-022053-idft1p6d 526 137 genome genome NN cord-022053-idft1p6d 526 138 sequencing sequencing NN cord-022053-idft1p6d 526 139 Single single JJ cord-022053-idft1p6d 526 140 - - HYPH cord-022053-idft1p6d 526 141 molecule molecule NN cord-022053-idft1p6d 526 142 sequencing sequencing NN cord-022053-idft1p6d 526 143 to to TO cord-022053-idft1p6d 526 144 track track VB cord-022053-idft1p6d 526 145 plasmid plasmid NN cord-022053-idft1p6d 526 146 diversity diversity NN cord-022053-idft1p6d 526 147 of of IN cord-022053-idft1p6d 526 148 hospital hospital NN cord-022053-idft1p6d 526 149 - - HYPH cord-022053-idft1p6d 526 150 associated associate VBN cord-022053-idft1p6d 526 151 carbapenemaseproducing carbapenemaseproduce VBG cord-022053-idft1p6d 526 152 Enterobacteriaceae Enterobacteriaceae NNP cord-022053-idft1p6d 526 153 Klebsiella Klebsiella NNP cord-022053-idft1p6d 526 154 pneumoniae pneumoniae NN cord-022053-idft1p6d 526 155 Carbapenemase Carbapenemase NNP cord-022053-idft1p6d 527 1 ( ( -LRB- cord-022053-idft1p6d 527 2 KPC)-producing kpc)-produce VBG cord-022053-idft1p6d 527 3 K. K. NNP cord-022053-idft1p6d 527 4 pneumoniae pneumoniae NN cord-022053-idft1p6d 527 5 at at IN cord-022053-idft1p6d 527 6 a a DT cord-022053-idft1p6d 527 7 single single JJ cord-022053-idft1p6d 527 8 institution institution NN cord-022053-idft1p6d 527 9 : : : cord-022053-idft1p6d 528 1 insights insight NNS cord-022053-idft1p6d 528 2 into into IN cord-022053-idft1p6d 528 3 endemicity endemicity NN cord-022053-idft1p6d 528 4 from from IN cord-022053-idft1p6d 528 5 whole whole JJ cord-022053-idft1p6d 528 6 - - HYPH cord-022053-idft1p6d 528 7 genome genome NN cord-022053-idft1p6d 528 8 sequencing sequencing NN cord-022053-idft1p6d 528 9 Genomically genomically RB cord-022053-idft1p6d 528 10 informed informed JJ cord-022053-idft1p6d 528 11 surveillance surveillance NN cord-022053-idft1p6d 528 12 for for IN cord-022053-idft1p6d 528 13 carbapenem carbapenem JJ cord-022053-idft1p6d 528 14 - - HYPH cord-022053-idft1p6d 528 15 resistant resistant JJ cord-022053-idft1p6d 528 16 enterobacteriaceae enterobacteriaceae NNS cord-022053-idft1p6d 528 17 in in IN cord-022053-idft1p6d 528 18 a a DT cord-022053-idft1p6d 528 19 health health NN cord-022053-idft1p6d 528 20 care care NN cord-022053-idft1p6d 528 21 system system NN cord-022053-idft1p6d 528 22 Plasmid Plasmid NNP cord-022053-idft1p6d 528 23 flux flux NN cord-022053-idft1p6d 528 24 in in IN cord-022053-idft1p6d 528 25 Escherichia Escherichia NNP cord-022053-idft1p6d 528 26 coli coli NNS cord-022053-idft1p6d 529 1 ST131 ST131 NNP cord-022053-idft1p6d 529 2 sublineages sublineages NNP cord-022053-idft1p6d 529 3 , , , cord-022053-idft1p6d 529 4 analyzed analyze VBN cord-022053-idft1p6d 529 5 by by IN cord-022053-idft1p6d 529 6 plasmid plasmid NNP cord-022053-idft1p6d 529 7 constellation constellation NN cord-022053-idft1p6d 529 8 network network NN cord-022053-idft1p6d 529 9 ( ( -LRB- cord-022053-idft1p6d 529 10 PLACNET PLACNET NNP cord-022053-idft1p6d 529 11 ) ) -RRB- cord-022053-idft1p6d 529 12 , , , cord-022053-idft1p6d 529 13 a a DT cord-022053-idft1p6d 529 14 new new JJ cord-022053-idft1p6d 529 15 method method NN cord-022053-idft1p6d 529 16 for for IN cord-022053-idft1p6d 529 17 plasmid plasmid NN cord-022053-idft1p6d 529 18 reconstruction reconstruction NN cord-022053-idft1p6d 529 19 from from IN cord-022053-idft1p6d 529 20 whole whole JJ cord-022053-idft1p6d 529 21 genome genome NN cord-022053-idft1p6d 529 22 sequences sequence NNS cord-022053-idft1p6d 530 1 A a DT cord-022053-idft1p6d 530 2 cloudcompatible cloudcompatible JJ cord-022053-idft1p6d 530 3 bioinformatics bioinformatics NN cord-022053-idft1p6d 530 4 pipeline pipeline NN cord-022053-idft1p6d 530 5 for for IN cord-022053-idft1p6d 530 6 ultrarapid ultrarapid NNP cord-022053-idft1p6d 530 7 pathogen pathogen NN cord-022053-idft1p6d 530 8 identification identification NN cord-022053-idft1p6d 530 9 from from IN cord-022053-idft1p6d 530 10 next next JJ cord-022053-idft1p6d 530 11 - - HYPH cord-022053-idft1p6d 530 12 generation generation NN cord-022053-idft1p6d 530 13 sequencing sequencing NN cord-022053-idft1p6d 530 14 of of IN cord-022053-idft1p6d 530 15 clinical clinical JJ cord-022053-idft1p6d 530 16 samples sample NNS cord-022053-idft1p6d 531 1 Actionable actionable JJ cord-022053-idft1p6d 531 2 diagnosis diagnosis NN cord-022053-idft1p6d 531 3 of of IN cord-022053-idft1p6d 531 4 neuroleptospirosis neuroleptospirosis NN cord-022053-idft1p6d 531 5 by by IN cord-022053-idft1p6d 531 6 next next JJ cord-022053-idft1p6d 531 7 - - HYPH cord-022053-idft1p6d 531 8 generation generation NN cord-022053-idft1p6d 531 9 sequencing sequencing NN cord-022053-idft1p6d 531 10 Mirror Mirror NNP cord-022053-idft1p6d 531 11 , , , cord-022053-idft1p6d 531 12 mirror mirror NN cord-022053-idft1p6d 531 13 on on IN cord-022053-idft1p6d 531 14 the the DT cord-022053-idft1p6d 531 15 wall wall NN cord-022053-idft1p6d 531 16 : : : cord-022053-idft1p6d 531 17 which which WDT cord-022053-idft1p6d 531 18 microbiomes microbiome NNS cord-022053-idft1p6d 531 19 will will MD cord-022053-idft1p6d 531 20 help help VB cord-022053-idft1p6d 531 21 heal heal VB cord-022053-idft1p6d 531 22 them -PRON- PRP cord-022053-idft1p6d 531 23 all all PDT cord-022053-idft1p6d 531 24 The the DT cord-022053-idft1p6d 531 25 microbiome microbiome NN cord-022053-idft1p6d 531 26 revolution revolution NN cord-022053-idft1p6d 532 1 The the DT cord-022053-idft1p6d 532 2 human human JJ cord-022053-idft1p6d 532 3 microbiome microbiome NN cord-022053-idft1p6d 532 4 : : : cord-022053-idft1p6d 532 5 at at IN cord-022053-idft1p6d 532 6 the the DT cord-022053-idft1p6d 532 7 interface interface NN cord-022053-idft1p6d 532 8 of of IN cord-022053-idft1p6d 532 9 health health NN cord-022053-idft1p6d 532 10 and and CC cord-022053-idft1p6d 532 11 disease disease NN cord-022053-idft1p6d 532 12 Sequencing sequence VBG cord-022053-idft1p6d 532 13 the the DT cord-022053-idft1p6d 532 14 human human JJ cord-022053-idft1p6d 532 15 microbiome microbiome NN cord-022053-idft1p6d 532 16 in in IN cord-022053-idft1p6d 532 17 health health NN cord-022053-idft1p6d 532 18 and and CC cord-022053-idft1p6d 532 19 disease disease NN cord-022053-idft1p6d 532 20 Characterization characterization NN cord-022053-idft1p6d 532 21 of of IN cord-022053-idft1p6d 532 22 the the DT cord-022053-idft1p6d 532 23 gut gut NN cord-022053-idft1p6d 532 24 microbiome microbiome NN cord-022053-idft1p6d 532 25 using use VBG cord-022053-idft1p6d 532 26 16S 16s CD cord-022053-idft1p6d 532 27 or or CC cord-022053-idft1p6d 532 28 shotgun shotgun NN cord-022053-idft1p6d 532 29 metagenomics metagenomic NNS cord-022053-idft1p6d 532 30 Broad broad JJ cord-022053-idft1p6d 532 31 - - HYPH cord-022053-idft1p6d 532 32 range range VBP cord-022053-idft1p6d 532 33 direct direct JJ cord-022053-idft1p6d 532 34 detection detection NN cord-022053-idft1p6d 532 35 and and CC cord-022053-idft1p6d 532 36 identification identification NN cord-022053-idft1p6d 532 37 of of IN cord-022053-idft1p6d 532 38 fungi fungus NNS cord-022053-idft1p6d 532 39 by by IN cord-022053-idft1p6d 532 40 use use NN cord-022053-idft1p6d 532 41 of of IN cord-022053-idft1p6d 532 42 the the DT cord-022053-idft1p6d 532 43 PLEX PLEX NNP cord-022053-idft1p6d 532 44 - - HYPH cord-022053-idft1p6d 532 45 ID ID NNP cord-022053-idft1p6d 532 46 PCR PCR NNP cord-022053-idft1p6d 532 47 - - HYPH cord-022053-idft1p6d 532 48 electrospray electrospray JJ cord-022053-idft1p6d 532 49 ionization ionization NN cord-022053-idft1p6d 532 50 mass mass NN cord-022053-idft1p6d 532 51 spectrometry spectrometry NN cord-022053-idft1p6d 532 52 ( ( -LRB- cord-022053-idft1p6d 533 1 ESI ESI NNP cord-022053-idft1p6d 533 2 - - HYPH cord-022053-idft1p6d 533 3 MS MS NNP cord-022053-idft1p6d 533 4 ) ) -RRB- cord-022053-idft1p6d 533 5 system system NN cord-022053-idft1p6d 534 1 Polymerase polymerase NN cord-022053-idft1p6d 534 2 - - HYPH cord-022053-idft1p6d 534 3 chain chain NN cord-022053-idft1p6d 534 4 reaction reaction NN cord-022053-idft1p6d 534 5 / / SYM cord-022053-idft1p6d 534 6 electrospray electrospray JJ cord-022053-idft1p6d 534 7 ionization ionization NN cord-022053-idft1p6d 534 8 - - HYPH cord-022053-idft1p6d 534 9 mass mass NN cord-022053-idft1p6d 534 10 spectrometry spectrometry NN cord-022053-idft1p6d 534 11 for for IN cord-022053-idft1p6d 534 12 the the DT cord-022053-idft1p6d 534 13 detection detection NN cord-022053-idft1p6d 534 14 of of IN cord-022053-idft1p6d 534 15 bacteria bacteria NNS cord-022053-idft1p6d 534 16 and and CC cord-022053-idft1p6d 534 17 fungi fungus NNS cord-022053-idft1p6d 534 18 in in IN cord-022053-idft1p6d 534 19 bronchoalveolar bronchoalveolar JJ cord-022053-idft1p6d 534 20 lavage lavage NN cord-022053-idft1p6d 534 21 fluids fluid NNS cord-022053-idft1p6d 534 22 : : : cord-022053-idft1p6d 534 23 a a DT cord-022053-idft1p6d 534 24 prospective prospective JJ cord-022053-idft1p6d 534 25 observational observational JJ cord-022053-idft1p6d 534 26 study study NN cord-022053-idft1p6d 534 27 Broad Broad NNP cord-022053-idft1p6d 534 28 - - HYPH cord-022053-idft1p6d 534 29 range range NN cord-022053-idft1p6d 534 30 PCRelectrospray pcrelectrospray NN cord-022053-idft1p6d 534 31 ionization ionization NN cord-022053-idft1p6d 534 32 mass mass NN cord-022053-idft1p6d 534 33 spectrometry spectrometry NN cord-022053-idft1p6d 534 34 for for IN cord-022053-idft1p6d 534 35 detection detection NN cord-022053-idft1p6d 534 36 and and CC cord-022053-idft1p6d 534 37 typing typing NN cord-022053-idft1p6d 534 38 of of IN cord-022053-idft1p6d 534 39 adenovirus adenovirus NN cord-022053-idft1p6d 534 40 and and CC cord-022053-idft1p6d 534 41 other other JJ cord-022053-idft1p6d 534 42 opportunistic opportunistic JJ cord-022053-idft1p6d 534 43 viruses virus NNS cord-022053-idft1p6d 534 44 in in IN cord-022053-idft1p6d 534 45 stem stem NN cord-022053-idft1p6d 534 46 cell cell NN cord-022053-idft1p6d 534 47 transplant transplant NN cord-022053-idft1p6d 534 48 patients patient NNS cord-022053-idft1p6d 534 49 Detection detection NN cord-022053-idft1p6d 534 50 and and CC cord-022053-idft1p6d 534 51 identification identification NN cord-022053-idft1p6d 534 52 of of IN cord-022053-idft1p6d 534 53 yeasts yeast NNS cord-022053-idft1p6d 534 54 from from IN cord-022053-idft1p6d 534 55 formalin formalin NN cord-022053-idft1p6d 534 56 - - HYPH cord-022053-idft1p6d 534 57 fixed fix VBN cord-022053-idft1p6d 534 58 , , , cord-022053-idft1p6d 534 59 paraffinembedded paraffinembedded JJ cord-022053-idft1p6d 534 60 tissue tissue NN cord-022053-idft1p6d 534 61 by by IN cord-022053-idft1p6d 534 62 use use NN cord-022053-idft1p6d 534 63 of of IN cord-022053-idft1p6d 534 64 PCR pcr NN cord-022053-idft1p6d 534 65 - - HYPH cord-022053-idft1p6d 534 66 electrospray electrospray JJ cord-022053-idft1p6d 534 67 ionization ionization NN cord-022053-idft1p6d 534 68 mass mass NN cord-022053-idft1p6d 534 69 spectrometry spectrometry NN cord-022053-idft1p6d 534 70 Advantages advantage NNS cord-022053-idft1p6d 534 71 and and CC cord-022053-idft1p6d 534 72 limitations limitation NNS cord-022053-idft1p6d 534 73 of of IN cord-022053-idft1p6d 534 74 direct direct JJ cord-022053-idft1p6d 534 75 PCR pcr NN cord-022053-idft1p6d 534 76 amplification amplification NN cord-022053-idft1p6d 534 77 of of IN cord-022053-idft1p6d 534 78 bacterial bacterial JJ cord-022053-idft1p6d 534 79 16S 16S NNPS cord-022053-idft1p6d 534 80 - - HYPH cord-022053-idft1p6d 534 81 rDNA rdna NN cord-022053-idft1p6d 534 82 from from IN cord-022053-idft1p6d 534 83 resected resected JJ cord-022053-idft1p6d 534 84 heart heart NN cord-022053-idft1p6d 534 85 tissue tissue NN cord-022053-idft1p6d 534 86 or or CC cord-022053-idft1p6d 534 87 swabs swab NNS cord-022053-idft1p6d 534 88 followed follow VBN cord-022053-idft1p6d 534 89 by by IN cord-022053-idft1p6d 534 90 direct direct JJ cord-022053-idft1p6d 534 91 sequencing sequencing NN cord-022053-idft1p6d 534 92 for for IN cord-022053-idft1p6d 534 93 diagnosing diagnose VBG cord-022053-idft1p6d 534 94 infective infective JJ cord-022053-idft1p6d 534 95 endocarditis endocarditis NN cord-022053-idft1p6d 534 96 : : : cord-022053-idft1p6d 534 97 a a DT cord-022053-idft1p6d 534 98 retrospective retrospective JJ cord-022053-idft1p6d 534 99 analysis analysis NN cord-022053-idft1p6d 534 100 in in IN cord-022053-idft1p6d 534 101 the the DT cord-022053-idft1p6d 534 102 routine routine JJ cord-022053-idft1p6d 534 103 clinical clinical JJ cord-022053-idft1p6d 534 104 setting setting NN cord-022053-idft1p6d 534 105 Using use VBG cord-022053-idft1p6d 534 106 PCR PCR NNP cord-022053-idft1p6d 534 107 - - HYPH cord-022053-idft1p6d 534 108 based base VBN cord-022053-idft1p6d 534 109 detection detection NN cord-022053-idft1p6d 534 110 and and CC cord-022053-idft1p6d 534 111 genotyping genotyping NN cord-022053-idft1p6d 534 112 to to TO cord-022053-idft1p6d 534 113 trace trace VB cord-022053-idft1p6d 534 114 Streptococcus streptococcus NN cord-022053-idft1p6d 534 115 salivarius salivarius NN cord-022053-idft1p6d 534 116 meningitis meningitis NN cord-022053-idft1p6d 534 117 outbreak outbreak NN cord-022053-idft1p6d 534 118 strain strain NN cord-022053-idft1p6d 534 119 to to IN cord-022053-idft1p6d 534 120 oral oral JJ cord-022053-idft1p6d 534 121 flora flora NNS cord-022053-idft1p6d 534 122 of of IN cord-022053-idft1p6d 534 123 radiology radiology NN cord-022053-idft1p6d 534 124 physician physician NN cord-022053-idft1p6d 534 125 assistant assistant NN cord-022053-idft1p6d 534 126 Analysis Analysis NNP cord-022053-idft1p6d 534 127 of of IN cord-022053-idft1p6d 534 128 525 525 CD cord-022053-idft1p6d 534 129 samples sample NNS cord-022053-idft1p6d 534 130 to to TO cord-022053-idft1p6d 534 131 determine determine VB cord-022053-idft1p6d 534 132 the the DT cord-022053-idft1p6d 534 133 usefulness usefulness NN cord-022053-idft1p6d 534 134 of of IN cord-022053-idft1p6d 534 135 PCR PCR NNP cord-022053-idft1p6d 534 136 amplification amplification NN cord-022053-idft1p6d 534 137 and and CC cord-022053-idft1p6d 534 138 sequencing sequencing NN cord-022053-idft1p6d 534 139 of of IN cord-022053-idft1p6d 534 140 the the DT cord-022053-idft1p6d 534 141 16S 16S NNP cord-022053-idft1p6d 534 142 rRNA rrna NN cord-022053-idft1p6d 534 143 gene gene NN cord-022053-idft1p6d 534 144 for for IN cord-022053-idft1p6d 534 145 diagnosis diagnosis NN cord-022053-idft1p6d 534 146 of of IN cord-022053-idft1p6d 534 147 bone bone NN cord-022053-idft1p6d 534 148 and and CC cord-022053-idft1p6d 534 149 joint joint JJ cord-022053-idft1p6d 534 150 infections infection NNS cord-022053-idft1p6d 534 151 Whipple Whipple NNP cord-022053-idft1p6d 534 152 disease disease NN cord-022053-idft1p6d 534 153 diagnosed diagnose VBN cord-022053-idft1p6d 534 154 with with IN cord-022053-idft1p6d 534 155 PCR PCR NNP cord-022053-idft1p6d 534 156 using use VBG cord-022053-idft1p6d 534 157 formalin formalin NN cord-022053-idft1p6d 534 158 - - HYPH cord-022053-idft1p6d 534 159 fixed fix VBN cord-022053-idft1p6d 534 160 paraffin paraffin NN cord-022053-idft1p6d 534 161 - - HYPH cord-022053-idft1p6d 534 162 embedded embed VBN cord-022053-idft1p6d 534 163 specimens specimen NNS cord-022053-idft1p6d 534 164 of of IN cord-022053-idft1p6d 534 165 the the DT cord-022053-idft1p6d 534 166 intestinal intestinal JJ cord-022053-idft1p6d 534 167 mucosa mucosa NN cord-022053-idft1p6d 534 168 Use use NN cord-022053-idft1p6d 534 169 of of IN cord-022053-idft1p6d 534 170 broad broad JJ cord-022053-idft1p6d 534 171 range16S range16 VBG cord-022053-idft1p6d 534 172 rDNA rDNA NNP cord-022053-idft1p6d 534 173 PCR PCR NNP cord-022053-idft1p6d 534 174 in in IN cord-022053-idft1p6d 534 175 clinical clinical JJ cord-022053-idft1p6d 534 176 microbiology microbiology NN cord-022053-idft1p6d 534 177 Nuclear Nuclear NNP cord-022053-idft1p6d 534 178 ribosomal ribosomal JJ cord-022053-idft1p6d 534 179 internal internal JJ cord-022053-idft1p6d 534 180 transcribed transcribe VBN cord-022053-idft1p6d 534 181 spacer spacer NN cord-022053-idft1p6d 534 182 ( ( -LRB- cord-022053-idft1p6d 534 183 ITS its PRP$ cord-022053-idft1p6d 534 184 ) ) -RRB- cord-022053-idft1p6d 534 185 region region NN cord-022053-idft1p6d 534 186 as as IN cord-022053-idft1p6d 534 187 a a DT cord-022053-idft1p6d 534 188 universal universal JJ cord-022053-idft1p6d 534 189 DNA dna NN cord-022053-idft1p6d 534 190 barcode barcode NN cord-022053-idft1p6d 534 191 marker marker NN cord-022053-idft1p6d 534 192 for for IN cord-022053-idft1p6d 534 193 Fungi Fungi NNP cord-022053-idft1p6d 534 194 DNA DNA NNP cord-022053-idft1p6d 534 195 barcoding barcoding NN cord-022053-idft1p6d 534 196 of of IN cord-022053-idft1p6d 534 197 fungi fungus NNS cord-022053-idft1p6d 534 198 causing cause VBG cord-022053-idft1p6d 534 199 infections infection NNS cord-022053-idft1p6d 534 200 in in IN cord-022053-idft1p6d 534 201 humans human NNS cord-022053-idft1p6d 534 202 and and CC cord-022053-idft1p6d 534 203 animals animal NNS cord-022053-idft1p6d 534 204 Intraspecific Intraspecific NNP cord-022053-idft1p6d 535 1 ITS its PRP$ cord-022053-idft1p6d 535 2 variability variability NN cord-022053-idft1p6d 535 3 in in IN cord-022053-idft1p6d 535 4 the the DT cord-022053-idft1p6d 535 5 kingdom kingdom NN cord-022053-idft1p6d 535 6 fungi fungus NNS cord-022053-idft1p6d 535 7 as as IN cord-022053-idft1p6d 535 8 expressed express VBN cord-022053-idft1p6d 535 9 in in IN cord-022053-idft1p6d 535 10 the the DT cord-022053-idft1p6d 535 11 international international JJ cord-022053-idft1p6d 535 12 sequence sequence NN cord-022053-idft1p6d 535 13 databases database NNS cord-022053-idft1p6d 535 14 and and CC cord-022053-idft1p6d 535 15 its -PRON- PRP$ cord-022053-idft1p6d 535 16 implications implication NNS cord-022053-idft1p6d 535 17 for for IN cord-022053-idft1p6d 535 18 molecular molecular JJ cord-022053-idft1p6d 535 19 species specie NNS cord-022053-idft1p6d 535 20 identification identification NN cord-022053-idft1p6d 535 21 Taxonomic taxonomic JJ cord-022053-idft1p6d 535 22 reliability reliability NN cord-022053-idft1p6d 535 23 of of IN cord-022053-idft1p6d 535 24 DNA dna NN cord-022053-idft1p6d 535 25 sequences sequence NNS cord-022053-idft1p6d 535 26 in in IN cord-022053-idft1p6d 535 27 public public JJ cord-022053-idft1p6d 535 28 sequence sequence NN cord-022053-idft1p6d 535 29 databases database NNS cord-022053-idft1p6d 535 30 : : : cord-022053-idft1p6d 535 31 a a DT cord-022053-idft1p6d 535 32 fungal fungal NN cord-022053-idft1p6d 535 33 perspective perspective NN cord-022053-idft1p6d 535 34 Evaluation evaluation NN cord-022053-idft1p6d 535 35 of of IN cord-022053-idft1p6d 535 36 nucleic nucleic JJ cord-022053-idft1p6d 535 37 acid acid NN cord-022053-idft1p6d 535 38 sequencing sequencing NN cord-022053-idft1p6d 535 39 of of IN cord-022053-idft1p6d 535 40 the the DT cord-022053-idft1p6d 535 41 D1 d1 NN cord-022053-idft1p6d 535 42 / / SYM cord-022053-idft1p6d 535 43 D2 d2 NN cord-022053-idft1p6d 535 44 region region NN cord-022053-idft1p6d 535 45 of of IN cord-022053-idft1p6d 535 46 the the DT cord-022053-idft1p6d 535 47 large large JJ cord-022053-idft1p6d 535 48 subunit subunit NN cord-022053-idft1p6d 535 49 of of IN cord-022053-idft1p6d 535 50 the the DT cord-022053-idft1p6d 535 51 28S 28S NNP cord-022053-idft1p6d 535 52 rDNA rDNA NNP cord-022053-idft1p6d 535 53 and and CC cord-022053-idft1p6d 535 54 the the DT cord-022053-idft1p6d 535 55 internal internal JJ cord-022053-idft1p6d 535 56 transcribed transcribe VBN cord-022053-idft1p6d 535 57 spacer spacer NN cord-022053-idft1p6d 535 58 region region NN cord-022053-idft1p6d 535 59 using use VBG cord-022053-idft1p6d 535 60 SmartGene SmartGene NNP cord-022053-idft1p6d 535 61 IDNS IDNS NNP cord-022053-idft1p6d 535 62 [ [ -LRB- cord-022053-idft1p6d 535 63 corrected correct VBN cord-022053-idft1p6d 535 64 ] ] -RRB- cord-022053-idft1p6d 535 65 software software NN cord-022053-idft1p6d 535 66 for for IN cord-022053-idft1p6d 535 67 identification identification NN cord-022053-idft1p6d 535 68 of of IN cord-022053-idft1p6d 535 69 filamentous filamentous JJ cord-022053-idft1p6d 535 70 fungi fungus NNS cord-022053-idft1p6d 535 71 in in IN cord-022053-idft1p6d 535 72 a a DT cord-022053-idft1p6d 535 73 clinical clinical JJ cord-022053-idft1p6d 535 74 laboratory laboratory NN cord-022053-idft1p6d 535 75 International International NNP cord-022053-idft1p6d 535 76 Society Society NNP cord-022053-idft1p6d 535 77 of of IN cord-022053-idft1p6d 535 78 Human Human NNP cord-022053-idft1p6d 535 79 and and CC cord-022053-idft1p6d 535 80 Animal Animal NNP cord-022053-idft1p6d 535 81 Mycology Mycology NNP cord-022053-idft1p6d 536 1 ( ( -LRB- cord-022053-idft1p6d 536 2 ISHAM)-ITS ISHAM)-ITS NNP cord-022053-idft1p6d 536 3 reference reference NN cord-022053-idft1p6d 536 4 DNA dna NN cord-022053-idft1p6d 536 5 barcoding barcoding NN cord-022053-idft1p6d 536 6 database database NN cord-022053-idft1p6d 536 7 - - : cord-022053-idft1p6d 536 8 the the DT cord-022053-idft1p6d 536 9 quality quality NN cord-022053-idft1p6d 536 10 controlled control VBN cord-022053-idft1p6d 536 11 standard standard JJ cord-022053-idft1p6d 536 12 tool tool NN cord-022053-idft1p6d 536 13 for for IN cord-022053-idft1p6d 536 14 routine routine JJ cord-022053-idft1p6d 536 15 identification identification NN cord-022053-idft1p6d 536 16 of of IN cord-022053-idft1p6d 536 17 human human JJ cord-022053-idft1p6d 536 18 and and CC cord-022053-idft1p6d 536 19 animal animal NN cord-022053-idft1p6d 536 20 pathogenic pathogenic JJ cord-022053-idft1p6d 536 21 fungi fungus NNS cord-022053-idft1p6d 536 22 Reference reference NN cord-022053-idft1p6d 536 23 sequence sequence NN cord-022053-idft1p6d 536 24 ( ( -LRB- cord-022053-idft1p6d 536 25 RefSeq RefSeq NNP cord-022053-idft1p6d 536 26 ) ) -RRB- cord-022053-idft1p6d 536 27 database database NN cord-022053-idft1p6d 536 28 at at IN cord-022053-idft1p6d 536 29 NCBI NCBI NNP cord-022053-idft1p6d 536 30 : : : cord-022053-idft1p6d 536 31 current current JJ cord-022053-idft1p6d 536 32 status status NN cord-022053-idft1p6d 536 33 , , , cord-022053-idft1p6d 536 34 taxonomic taxonomic JJ cord-022053-idft1p6d 536 35 expansion expansion NN cord-022053-idft1p6d 536 36 , , , cord-022053-idft1p6d 536 37 and and CC cord-022053-idft1p6d 536 38 functional functional JJ cord-022053-idft1p6d 536 39 annotation annotation NN cord-022053-idft1p6d 536 40 Utility utility NN cord-022053-idft1p6d 536 41 of of IN cord-022053-idft1p6d 536 42 DNA dna NN cord-022053-idft1p6d 536 43 sequencing sequencing NN cord-022053-idft1p6d 536 44 for for IN cord-022053-idft1p6d 536 45 direct direct JJ cord-022053-idft1p6d 536 46 identification identification NN cord-022053-idft1p6d 536 47 of of IN cord-022053-idft1p6d 536 48 invasive invasive JJ cord-022053-idft1p6d 536 49 fungi fungus NNS cord-022053-idft1p6d 536 50 from from IN cord-022053-idft1p6d 536 51 fresh fresh JJ cord-022053-idft1p6d 536 52 and and CC cord-022053-idft1p6d 536 53 formalin formalin NN cord-022053-idft1p6d 536 54 - - HYPH cord-022053-idft1p6d 536 55 fixed fix VBN cord-022053-idft1p6d 536 56 specimens specimen NNS cord-022053-idft1p6d 536 57 Molecular molecular JJ cord-022053-idft1p6d 536 58 methods method NNS cord-022053-idft1p6d 536 59 to to TO cord-022053-idft1p6d 536 60 improve improve VB cord-022053-idft1p6d 536 61 diagnosis diagnosis NN cord-022053-idft1p6d 536 62 and and CC cord-022053-idft1p6d 536 63 identification identification NN cord-022053-idft1p6d 536 64 of of IN cord-022053-idft1p6d 536 65 mucormycosis mucormycosis FW cord-022053-idft1p6d 536 66 Direct direct JJ cord-022053-idft1p6d 536 67 sequencing sequencing NN cord-022053-idft1p6d 536 68 and and CC cord-022053-idft1p6d 536 69 RipSeq RipSeq NNP cord-022053-idft1p6d 536 70 interpretation interpretation NN cord-022053-idft1p6d 536 71 as as IN cord-022053-idft1p6d 536 72 a a DT cord-022053-idft1p6d 536 73 tool tool NN cord-022053-idft1p6d 536 74 for for IN cord-022053-idft1p6d 536 75 identification identification NN cord-022053-idft1p6d 536 76 of of IN cord-022053-idft1p6d 536 77 polymicrobial polymicrobial JJ cord-022053-idft1p6d 536 78 infections infection NNS cord-022053-idft1p6d 536 79 High high JJ cord-022053-idft1p6d 536 80 - - HYPH cord-022053-idft1p6d 536 81 throughput throughput NN cord-022053-idft1p6d 536 82 sequencing sequencing NN cord-022053-idft1p6d 536 83 technologies technology NNS cord-022053-idft1p6d 537 1 A a DT cord-022053-idft1p6d 537 2 glimpse glimpse NN cord-022053-idft1p6d 537 3 into into IN cord-022053-idft1p6d 537 4 past past NN cord-022053-idft1p6d 537 5 , , , cord-022053-idft1p6d 537 6 present present JJ cord-022053-idft1p6d 537 7 , , , cord-022053-idft1p6d 537 8 and and CC cord-022053-idft1p6d 537 9 future future JJ cord-022053-idft1p6d 537 10 DNA dna NN cord-022053-idft1p6d 537 11 sequencing sequencing NN cord-022053-idft1p6d 537 12 Making make VBG cord-022053-idft1p6d 537 13 the the DT cord-022053-idft1p6d 537 14 leap leap NN cord-022053-idft1p6d 537 15 from from IN cord-022053-idft1p6d 537 16 research research NN cord-022053-idft1p6d 537 17 laboratory laboratory NN cord-022053-idft1p6d 537 18 to to IN cord-022053-idft1p6d 537 19 clinic clinic NN cord-022053-idft1p6d 537 20 : : : cord-022053-idft1p6d 537 21 challenges challenge NNS cord-022053-idft1p6d 537 22 and and CC cord-022053-idft1p6d 537 23 opportunities opportunity NNS cord-022053-idft1p6d 537 24 for for IN cord-022053-idft1p6d 537 25 next next JJ cord-022053-idft1p6d 537 26 - - HYPH cord-022053-idft1p6d 537 27 generation generation NN cord-022053-idft1p6d 537 28 sequencing sequencing NN cord-022053-idft1p6d 537 29 in in IN cord-022053-idft1p6d 537 30 infectious infectious JJ cord-022053-idft1p6d 537 31 disease disease NN cord-022053-idft1p6d 537 32 diagnostics diagnostic NNS