id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-281179-k7630is6	Brown, Meredith A.	Genetic determinants of pathogenesis by feline infectious peritonitis virus	2011-10-15		.txt	text/plain	3212	169	45	Feline infectious peritonitis (FIP) is a fatal, immune-augmented, and progressive viral disease of cats associated with feline coronavirus (FCoV). Feline infectious peritonitis (FIP) is a fatal, immune-augmented, and progressive viral disease of cats associated with feline coronavirus (FCoV). Mutational transition in viral pathogenesis has been shown in HIV infection, where specific amino acid changes in the envelope gene determine which coreceptor (CCR5 or CXCR4) is used and hence virus success in cell entry (Hartley et al., 2005) . However, more recent in vitro studies of cathepsin B and cathepsin L activity in different isolates of FCoV showed that FECV isolates were able to induce a specific cleavage event in the spike protein in contrast to FIPV isolates, suggesting that cathepsin activity on the spike gene may play a role in viral pathogenesis at the level of cell entry .	./cache/cord-281179-k7630is6.txt	./txt/cord-281179-k7630is6.txt