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Helen; Specchio, Nicola; Nabbout, Rima title: An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic date: 2020-08-31 journal: Epilepsy Behav DOI: 10.1016/j.yebeh.2020.107376 sha: doc_id: 285187 cord_uid: 1h5tjs0r file: cache/cord-264203-7dnz9yaa.json key: cord-264203-7dnz9yaa authors: Coldefy, Magali; Curtis, Sarah E. title: The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness date: 2010-10-10 journal: Soc Sci Med DOI: 10.1016/j.socscimed.2010.09.028 sha: doc_id: 264203 cord_uid: 7dnz9yaa file: cache/cord-252950-eiphxwmn.json key: cord-252950-eiphxwmn authors: Trouillet-Assant, Sophie; Viel, Sebastien; Gaymard, Alexandre; Pons, Sylvie; Richard, Jean-Christophe; Perret, Magali; Villard, Marine; Brengel-Pesce, Karen; Lina, Bruno; Mezidi, Mehdi; Bitker, Laurent; Belot, Alexandre title: Type I IFN immunoprofiling in COVID-19 patients date: 2020-04-29 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2020.04.029 sha: doc_id: 252950 cord_uid: eiphxwmn file: cache/cord-272085-4mqc8mqd.json key: cord-272085-4mqc8mqd authors: Roques, Lionel; Klein, Etienne K.; Papaïx, Julien; Sar, Antoine; Soubeyrand, Samuel title: Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France date: 2020-06-05 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00274 sha: doc_id: 272085 cord_uid: 4mqc8mqd file: cache/cord-021158-075vh5jg.json key: cord-021158-075vh5jg authors: Fortané, Nicolas title: Antimicrobial resistance: preventive approaches to the rescue? 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F. title: Study of Coronavirus Impact on Parisian Population from April to June using Twitter and Text Mining Approach date: 2020-08-18 journal: nan DOI: 10.1101/2020.08.15.20175810 sha: doc_id: 319418 cord_uid: ao0df0q7 file: cache/cord-016095-jop2rx61.json key: cord-016095-jop2rx61 authors: Vignais, Pierre V.; Vignais, Paulette M. title: Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century date: 2010-06-08 journal: Discovering Life, Manufacturing Life DOI: 10.1007/978-90-481-3767-1_5 sha: doc_id: 16095 cord_uid: jop2rx61 file: cache/cord-318701-f9j13fsc.json key: cord-318701-f9j13fsc authors: Chamboredon, P.; Roman, C.; Colson, S. title: COVID‐19 pandemic in France: health emergency experiences from the field date: 2020-06-22 journal: Int Nurs Rev DOI: 10.1111/inr.12604 sha: doc_id: 318701 cord_uid: f9j13fsc file: cache/cord-335297-vxhta6a4.json key: cord-335297-vxhta6a4 authors: Véran, Emilie; Gallay-Lepoutre, Julie; Gory, Guillaume; Guillaumot, Pierre; Duboy, Julie title: Chyloabdomen in a cat with pancreatic carcinoma date: 2018-11-24 journal: Open Vet J DOI: 10.4314/ovj.v8i4.16 sha: doc_id: 335297 cord_uid: vxhta6a4 file: cache/cord-292475-jrl1fowa.json key: cord-292475-jrl1fowa authors: Abry, Patrice; Pustelnik, Nelly; Roux, Stéphane; Jensen, Pablo; Flandrin, Patrick; Gribonval, Rémi; Lucas, Charles-Gérard; Guichard, Éric; Borgnat, Pierre; Garnier, Nicolas title: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization date: 2020-08-20 journal: PLoS One DOI: 10.1371/journal.pone.0237901 sha: doc_id: 292475 cord_uid: jrl1fowa file: cache/cord-282095-cbfyydi3.json key: cord-282095-cbfyydi3 authors: Pierron, Denis; Pereda-Loth, Veronica; Mantel, Marylou; Moranges, Maëlle; Bignon, Emmanuelle; Alva, Omar; Kabous, Julie; Heiske, Margit; Pacalon, Jody; David, Renaud; Dinnella, Caterina; Spinelli, Sara; Monteleone, Erminio; Farruggia, Michael C.; Cooper, Keiland W.; 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Brown, Paul; Bernard, Cécilia; Blanchard, Yannick; Grasland, Béatrice title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR date: 2020-05-31 journal: J Virol Methods DOI: 10.1016/j.jviromet.2020.113906 sha: doc_id: 331509 cord_uid: p19dg1jw file: cache/cord-335215-h9p4kmss.json key: cord-335215-h9p4kmss authors: Follet, Jérôme; Guyot, Karine; Leruste, Hélène; Follet-Dumoulin, Anne; Hammouma-Ghelboun, Ourida; Certad, Gabriela; Dei-Cas, Eduardo; Halama, Patrice title: Cryptosporidium infection in a veal calf cohort in France: molecular characterization of species in a longitudinal study date: 2011-12-02 journal: Vet Res DOI: 10.1186/1297-9716-42-116 sha: doc_id: 335215 cord_uid: h9p4kmss file: cache/cord-014538-6a2pviol.json key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; 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Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-339820-x8r27w14.json key: cord-339820-x8r27w14 authors: Guan, L.; Prieur, C.; Zhang, L.; Georges, D.; Bellemain, P. title: Transport effect of COVID-19 pandemic in France date: 2020-07-29 journal: nan DOI: 10.1101/2020.07.27.20161430 sha: doc_id: 339820 cord_uid: x8r27w14 file: cache/cord-344984-mg779mix.json key: cord-344984-mg779mix authors: Bitar, Dounia; Tarantola, Arnaud; Capek, Isabelle; Barboza, Philippe; Che, Didier title: Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse date: 2009-11-30 journal: Bulletin de l'Académie Nationale de Médecine DOI: 10.1016/s0001-4079(19)32418-5 sha: doc_id: 344984 cord_uid: mg779mix file: cache/cord-344020-8poerd09.json key: cord-344020-8poerd09 authors: Vermeulen, Tom D; Reimerink, Johan; Reusken, Chantal; Giron, Sandra; de Vries, Peter J title: Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020 date: 2020-10-01 journal: Euro Surveill DOI: 10.2807/1560-7917.es.2020.25.39.2001670 sha: doc_id: 344020 cord_uid: 8poerd09 file: cache/cord-015334-8p124rwp.json key: cord-015334-8p124rwp authors: nan title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 journal: Pharm World Sci DOI: 10.1007/s11096-008-9226-3 sha: doc_id: 15334 cord_uid: 8p124rwp file: cache/cord-337744-g17qe8fi.json key: cord-337744-g17qe8fi authors: Pullano, G.; Valdano, E.; Scarpa, N.; Rubrichi, S.; Colizza, V. title: Population mobility reductions during COVID-19 epidemic in France under lockdown date: 2020-06-01 journal: nan DOI: 10.1101/2020.05.29.20097097 sha: doc_id: 337744 cord_uid: g17qe8fi file: cache/cord-335252-med3c01q.json key: cord-335252-med3c01q authors: Fovet, Thomas; Lancelevee, Camille; Eck, Marion; Scouflaire, Tatiana; Becache, Eve; Dandelot, Dominique; Giravalli, Pascale; Guillard, Alexandre; Horrach, Pierre; Lacambre, Mathieu; Lefebvre, Tiphaine; Moncany, Anne-Hélène; Touitou, David; David, Michel; Thomas, Pierre title: Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France? date: 2020-05-08 journal: Encephale DOI: 10.1016/j.encep.2020.05.002 sha: doc_id: 335252 cord_uid: med3c01q file: cache/cord-340298-0l4pec0z.json key: cord-340298-0l4pec0z authors: Terriau, A.; Albertini, J.; Poirier, A.; LE BASTARD, Q. title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model date: 2020-05-01 journal: nan DOI: 10.1101/2020.04.26.20080531 sha: doc_id: 340298 cord_uid: 0l4pec0z file: cache/cord-355549-6xnjj5h5.json key: cord-355549-6xnjj5h5 authors: Cécile, Couchoud; Florian, Bayer; Carole, Ayav; Clémence, Béchade; Philippe, Brunet; François, Chantrel; Luc, Frimat; Roula, Galland; Maryvonne, Hourmant; Emmanuelle, Laurain; Thierry, Lobbedez; Lucile, Mercadal; Olivier, Moranne title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 journal: Kidney Int DOI: 10.1016/j.kint.2020.07.042 sha: doc_id: 355549 cord_uid: 6xnjj5h5 file: cache/cord-347244-abxv2mkz.json key: cord-347244-abxv2mkz authors: Izopet, Jacques; Dubois, Martine; Bertagnoli, Stéphane; Lhomme, Sébastien; Marchandeau, Stéphane; Boucher, Samuel; Kamar, Nassim; Abravanel, Florence; Guérin, Jean-Luc title: Hepatitis E Virus Strains in Rabbits and Evidence of a Closely Related Strain in Humans, France date: 2012-08-17 journal: Emerg Infect Dis DOI: 10.3201/eid1808.120057 sha: doc_id: 347244 cord_uid: abxv2mkz file: cache/cord-004534-jqm1hxps.json key: cord-004534-jqm1hxps authors: nan title: Abstract date: 2009-06-09 journal: Eur Biophys J DOI: 10.1007/s00249-009-0478-1 sha: doc_id: 4534 cord_uid: jqm1hxps file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox file: cache/cord-350571-6tapkjb6.json key: cord-350571-6tapkjb6 authors: nan title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 journal: Int J Clin Pharm DOI: 10.1007/s11096-016-0404-4 sha: doc_id: 350571 cord_uid: 6tapkjb6 file: cache/cord-023049-fio7cjj5.json key: cord-023049-fio7cjj5 authors: nan title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 journal: J Peripher Nerv Syst DOI: 10.1111/jns.12225 sha: doc_id: 23049 cord_uid: fio7cjj5 file: cache/cord-007890-bie1veti.json key: cord-007890-bie1veti authors: nan title: ECC-4 Abstracts date: 2002-04-16 journal: Int J Antimicrob Agents DOI: 10.1016/s0924-8579(02)00033-x sha: doc_id: 7890 cord_uid: bie1veti Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-france-cord /data-disk/reader-compute/reader-cord/bin/map.sh: fork: retry: Resource temporarily unavailable parallel: Warning: Only enough available processes to run 5 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18981 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18084 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 17849 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 17914 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18157 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 17926 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 18290 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 17946 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-284616-jgtsl06q author: Harkouk, Hakim title: Urgent development of an anaesthesiology-based intensive care unit for critical COVID-19 infected patients date: 2020-05-04 pages: extension: .txt txt: ./txt/cord-284616-jgtsl06q.txt cache: ./cache/cord-284616-jgtsl06q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-284616-jgtsl06q.txt' === file2bib.sh === id: cord-252950-eiphxwmn author: Trouillet-Assant, Sophie title: Type I IFN immunoprofiling in COVID-19 patients date: 2020-04-29 pages: extension: .txt txt: ./txt/cord-252950-eiphxwmn.txt cache: ./cache/cord-252950-eiphxwmn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-252950-eiphxwmn.txt' === file2bib.sh === id: cord-314884-110nqkej author: Lansiaux, Édouard title: Covid-19 And Vit-D: Disease Mortality Negatively Correlates With Sunlight Exposure date: 2020-07-23 pages: extension: .txt txt: ./txt/cord-314884-110nqkej.txt cache: ./cache/cord-314884-110nqkej.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-314884-110nqkej.txt' === file2bib.sh === id: cord-344020-8poerd09 author: Vermeulen, Tom D title: Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020 date: 2020-10-01 pages: extension: .txt txt: ./txt/cord-344020-8poerd09.txt cache: ./cache/cord-344020-8poerd09.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344020-8poerd09.txt' === file2bib.sh === id: cord-257325-pvf0uon3 author: Zeitoun, Jean-David title: Impact of Local Care Environment and Social Characteristics on Aggregated Hospital-Fatality Rate from COVID-19 in France: Nationwide Observational Study date: 2020-10-10 pages: extension: .txt txt: ./txt/cord-257325-pvf0uon3.txt cache: ./cache/cord-257325-pvf0uon3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-257325-pvf0uon3.txt' === file2bib.sh === id: cord-253801-y1nherse author: Lepelletier, Didier title: Risque d’introduction et voies d’importation par l’homme de maladies infectieuses exotiques : cas particulier de l’émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l’occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l’étranger date: 2009-11-30 pages: extension: .txt txt: ./txt/cord-253801-y1nherse.txt cache: ./cache/cord-253801-y1nherse.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-253801-y1nherse.txt' === file2bib.sh === id: cord-262046-bb8ekgdm author: Unlu, E. title: Epidemic analysis of COVID-19 Outbreak and Counter-Measures in France date: 2020-05-01 pages: extension: .txt txt: ./txt/cord-262046-bb8ekgdm.txt cache: ./cache/cord-262046-bb8ekgdm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-262046-bb8ekgdm.txt' === file2bib.sh === id: cord-272085-4mqc8mqd author: Roques, Lionel title: Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-272085-4mqc8mqd.txt cache: ./cache/cord-272085-4mqc8mqd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272085-4mqc8mqd.txt' === file2bib.sh === id: cord-331509-p19dg1jw author: Bigault, Lionel title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR date: 2020-05-31 pages: extension: .txt txt: ./txt/cord-331509-p19dg1jw.txt cache: ./cache/cord-331509-p19dg1jw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-331509-p19dg1jw.txt' === file2bib.sh === id: cord-335297-vxhta6a4 author: Véran, Emilie title: Chyloabdomen in a cat with pancreatic carcinoma date: 2018-11-24 pages: extension: .txt txt: ./txt/cord-335297-vxhta6a4.txt cache: ./cache/cord-335297-vxhta6a4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-335297-vxhta6a4.txt' === file2bib.sh === id: cord-335252-med3c01q author: Fovet, Thomas title: Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France? date: 2020-05-08 pages: extension: .txt txt: ./txt/cord-335252-med3c01q.txt cache: ./cache/cord-335252-med3c01q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-335252-med3c01q.txt' === file2bib.sh === id: cord-318701-f9j13fsc author: Chamboredon, P. title: COVID‐19 pandemic in France: health emergency experiences from the field date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-318701-f9j13fsc.txt cache: ./cache/cord-318701-f9j13fsc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-318701-f9j13fsc.txt' === file2bib.sh === id: cord-340298-0l4pec0z author: Terriau, A. title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model date: 2020-05-01 pages: extension: .txt txt: ./txt/cord-340298-0l4pec0z.txt cache: ./cache/cord-340298-0l4pec0z.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-340298-0l4pec0z.txt' === file2bib.sh === id: cord-275827-r86ygqmy author: Lapeyre-Mestre, Maryse title: Addictovigilance contribution during COVID-19 epidemic and lockdown in France date: 2020-06-23 pages: extension: .txt txt: ./txt/cord-275827-r86ygqmy.txt cache: ./cache/cord-275827-r86ygqmy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-275827-r86ygqmy.txt' === file2bib.sh === id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 pages: extension: .txt txt: ./txt/cord-355549-6xnjj5h5.txt cache: ./cache/cord-355549-6xnjj5h5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-355549-6xnjj5h5.txt' === file2bib.sh === id: cord-320636-mvtux07x author: Pullano, G. title: Underdetection of COVID-19 cases in France in the exit phase following lockdown date: 2020-08-12 pages: extension: .txt txt: ./txt/cord-320636-mvtux07x.txt cache: ./cache/cord-320636-mvtux07x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-320636-mvtux07x.txt' === file2bib.sh === id: cord-337744-g17qe8fi author: Pullano, G. title: Population mobility reductions during COVID-19 epidemic in France under lockdown date: 2020-06-01 pages: extension: .txt txt: ./txt/cord-337744-g17qe8fi.txt cache: ./cache/cord-337744-g17qe8fi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-337744-g17qe8fi.txt' === file2bib.sh === id: cord-339820-x8r27w14 author: Guan, L. title: Transport effect of COVID-19 pandemic in France date: 2020-07-29 pages: extension: .txt txt: ./txt/cord-339820-x8r27w14.txt cache: ./cache/cord-339820-x8r27w14.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339820-x8r27w14.txt' === file2bib.sh === id: cord-285187-1h5tjs0r author: Kuchenbuch, Mathieu title: An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic date: 2020-08-31 pages: extension: .txt txt: ./txt/cord-285187-1h5tjs0r.txt cache: ./cache/cord-285187-1h5tjs0r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285187-1h5tjs0r.txt' === file2bib.sh === id: cord-320773-zisujjsx author: Sabat, Iryna title: United but divided: policy responses and people's perceptions in the EU during the COVID-19 outbreak date: 2020-06-22 pages: extension: .txt txt: ./txt/cord-320773-zisujjsx.txt cache: ./cache/cord-320773-zisujjsx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-320773-zisujjsx.txt' === file2bib.sh === id: cord-299846-yx18oyv6 author: Amar, Patrick title: Pandæsim: An Epidemic Spreading Stochastic Simulator date: 2020-09-18 pages: extension: .txt txt: ./txt/cord-299846-yx18oyv6.txt cache: ./cache/cord-299846-yx18oyv6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-299846-yx18oyv6.txt' === file2bib.sh === id: cord-000425-isw6jeir author: Flori, Laurence title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date: 2011-07-29 pages: extension: .txt txt: ./txt/cord-000425-isw6jeir.txt cache: ./cache/cord-000425-isw6jeir.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-000425-isw6jeir.txt' === file2bib.sh === id: cord-267867-q52nvn0n author: Chevalier, Christophe title: Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs date: 2016-12-14 pages: extension: .txt txt: ./txt/cord-267867-q52nvn0n.txt cache: ./cache/cord-267867-q52nvn0n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-267867-q52nvn0n.txt' === file2bib.sh === id: cord-288079-rr8h5dgy author: Prague, Melanie title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate date: 2020-04-24 pages: extension: .txt txt: ./txt/cord-288079-rr8h5dgy.txt cache: ./cache/cord-288079-rr8h5dgy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-288079-rr8h5dgy.txt' === file2bib.sh === id: cord-264203-7dnz9yaa author: Coldefy, Magali title: The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness date: 2010-10-10 pages: extension: .txt txt: ./txt/cord-264203-7dnz9yaa.txt cache: ./cache/cord-264203-7dnz9yaa.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-264203-7dnz9yaa.txt' === file2bib.sh === id: cord-021158-075vh5jg author: Fortané, Nicolas title: Antimicrobial resistance: preventive approaches to the rescue? Professional expertise and business model of French “industrial” veterinarians date: 2020-01-06 pages: extension: .txt txt: ./txt/cord-021158-075vh5jg.txt cache: ./cache/cord-021158-075vh5jg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-021158-075vh5jg.txt' === file2bib.sh === id: cord-014685-ihh30q6f author: nan title: Posters P788 - P999 date: 2005-09-21 pages: extension: .txt txt: ./txt/cord-014685-ihh30q6f.txt cache: ./cache/cord-014685-ihh30q6f.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-014685-ihh30q6f.txt' === file2bib.sh === id: cord-016095-jop2rx61 author: Vignais, Pierre V. title: Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century date: 2010-06-08 pages: extension: .txt txt: ./txt/cord-016095-jop2rx61.txt cache: ./cache/cord-016095-jop2rx61.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-016095-jop2rx61.txt' === file2bib.sh === id: cord-015334-8p124rwp author: nan title: ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date: 2008-06-11 pages: extension: .txt txt: ./txt/cord-015334-8p124rwp.txt cache: ./cache/cord-015334-8p124rwp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-015334-8p124rwp.txt' === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-007890-bie1veti author: nan title: ECC-4 Abstracts date: 2002-04-16 pages: extension: .txt txt: ./txt/cord-007890-bie1veti.txt cache: ./cache/cord-007890-bie1veti.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-007890-bie1veti.txt' === file2bib.sh === id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 pages: extension: .txt txt: ./txt/cord-355038-o2hr5mox.txt cache: ./cache/cord-355038-o2hr5mox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-355038-o2hr5mox.txt' === file2bib.sh === id: cord-350571-6tapkjb6 author: nan title: 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-350571-6tapkjb6.txt cache: ./cache/cord-350571-6tapkjb6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 13 resourceName b'cord-350571-6tapkjb6.txt' === file2bib.sh === id: cord-004534-jqm1hxps author: nan title: Abstract date: 2009-06-09 pages: extension: .txt txt: ./txt/cord-004534-jqm1hxps.txt cache: ./cache/cord-004534-jqm1hxps.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 24 resourceName b'cord-004534-jqm1hxps.txt' === file2bib.sh === id: cord-023049-fio7cjj5 author: nan title: 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date: 2017-06-22 pages: extension: .txt txt: ./txt/cord-023049-fio7cjj5.txt cache: ./cache/cord-023049-fio7cjj5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-023049-fio7cjj5.txt' Que is empty; done keyword-france-cord === reduce.pl bib === id = cord-262046-bb8ekgdm author = Unlu, E. title = Epidemic analysis of COVID-19 Outbreak and Counter-Measures in France date = 2020-05-01 pages = extension = .txt mime = text/plain words = 2879 sentences = 160 flesch = 54 summary = We propose to use a variant of the well known SEIR model to analyze the spread of COVID-19 in France, by taking in to account the national lockdown declared in March 11, 2020. As number of confirmed cases shall not be fully representative due to low testing especially in the first phases of the outbreak, we present that basing the model optimisation on the fatalities can provide legitimate results. Note that, with this approach the initial state values are also defined in terms of proportion of fatalities, hence they also are parameters of the PSO optimization. Using the developed model we predict that if lockdown continues with strict measures, the total number of COVID-19 fatalities should topple below 50,000 (which is currently around 20,000) by late August, 2020; where the effects of the epidemic start to significantly diminish. cache = ./cache/cord-262046-bb8ekgdm.txt txt = ./txt/cord-262046-bb8ekgdm.txt === reduce.pl bib === id = cord-284616-jgtsl06q author = Harkouk, Hakim title = Urgent development of an anaesthesiology-based intensive care unit for critical COVID-19 infected patients date = 2020-05-04 pages = extension = .txt mime = text/plain words = 1045 sentences = 58 flesch = 44 summary = A regulatory team headed by an anaesthesiologist with the help of surgeons, usually meeting once a week, decides a new organisation evaluating rapidly both management of critical negative and positive COVID-19 patients and surgical activity; chronological details are listed in Table 1 The man-power includes 40 anaesthetist nurses and RR nurses and 10 anaesthesiologists (2 anaesthesiologists present 24 hours a day). This radical reorganisation within 2 weeks of an operating theatre and a RR relies on the professional, structural and material resources of an anaesthesia department to create an ICU with 10 beds dedicated to critical COVID-19 infected patients while maintaining the management of selected scheduled and emergency surgery. We report our experience with mobilisation of an anaesthesia team and use of existing structures for urgent creation of an ICU managing critical COVID-19 patients in a pandemic which exceeds the usual resources of resuscitation structures. cache = ./cache/cord-284616-jgtsl06q.txt txt = ./txt/cord-284616-jgtsl06q.txt === reduce.pl bib === id = cord-000425-isw6jeir author = Flori, Laurence title = Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date = 2011-07-29 pages = extension = .txt mime = text/plain words = 7831 sentences = 388 flesch = 46 summary = A study on Yorkshire pigs selected for eight generations for high and low adaptive IR (HIR and LIR, respectively) on an index combining four standardized measures of specific antibodies and cellmediated IR, after stimulation with specific antigens (bacillus Calmette-Guérin and hen egg white lysozyme), has revealed that HIR and LIR animals differ in response to immunization and infection [2, 11, 12, 13, 14] . Finally, several significant QTLs for total leukocyte count ( [20, 21] ; Animal-QTLdb, http://www.animalgenome.org/cgi-bin/QTLdb/index), mitogen-induced proliferation [20] , antibody response [20, 22] , cytokine production (IL10 and IFNc) [23] , complement activity [22] , and acute phase protein serum concentration [22] have been detected and mapped to different pig chromosomes. In this report, we present the results of a global genetic study, combining principal component analysis (PCA), and genetic parameter estimation applied to a large number of innate and adaptive ITs in a pig population vaccinated against Mycoplasma hyopneumoniae (M. cache = ./cache/cord-000425-isw6jeir.txt txt = ./txt/cord-000425-isw6jeir.txt === reduce.pl bib === id = cord-285187-1h5tjs0r author = Kuchenbuch, Mathieu title = An accelerated shift in the use of remote systems in epilepsy due to the COVID-19 pandemic date = 2020-08-31 pages = extension = .txt mime = text/plain words = 4826 sentences = 248 flesch = 51 summary = PURPOSE: The purpose of the study was to describe epileptologists' opinion on the increased use of remote systems implemented during the COVID-19 pandemic across clinics, education, and scientific meetings activities. Interestingly, before the COVID-19 pandemic, remote systems were significantly more frequently used in China for clinical activity compared with France or Italy. The aim of this study was to assess the impact of the COVID-19 pandemic on the acute use of remote systems in clinics, education, and scientific meetings in the field of epilepsy and to explore the users' satisfaction and the perspectives of future use. We conducted a cross-sectional, electronic survey of epileptologists, neurologists, and pediatric neurologists mainly involved in the epilepsy field to determine the use of remote work during the COVID-19 pandemic (supplementary data). Before the COVID-19 pandemic, the rate of respondents who had experienced remote working systems was higher in China than in the two other countries (91.6% versus 61.7% for France and 25% for Italy, p = 10 −4 ). cache = ./cache/cord-285187-1h5tjs0r.txt txt = ./txt/cord-285187-1h5tjs0r.txt === reduce.pl bib === id = cord-264203-7dnz9yaa author = Coldefy, Magali title = The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness date = 2010-10-10 pages = extension = .txt mime = text/plain words = 11259 sentences = 493 flesch = 43 summary = It seems that trends depend on national context since a rather contrasting American study (Hunter, Shannon, & Sambrook, 1986) , reports the emergence and diffusion of public 'lunatic asylums' in the United States during the 19th century, demonstrating how over time the establishment of these facilities spread from the north-east to the west of the country. To investigate spatial diffusion of psychiatric hospitals in France from the 19th century to the present day, the initial task involved building an original historical database of psychiatric hospitals, their location and date of establishment, indicating the points at which, in different parts of France, asylum facilities were first adopted as innovative care institutions for the mentally ill. For example, a psychiatric ward in a general hospital, could have constituted an 'acceptable' way of caring for people with mental health problems in a département and such provision may have resulted in a delay in the establishment of a dedicated asylum facility in that area, or progressive independent institutions may have played a role in the dissemination of alienist ideas in psychiatry. cache = ./cache/cord-264203-7dnz9yaa.txt txt = ./txt/cord-264203-7dnz9yaa.txt === reduce.pl bib === id = cord-272085-4mqc8mqd author = Roques, Lionel title = Impact of Lockdown on the Epidemic Dynamics of COVID-19 in France date = 2020-06-05 pages = extension = .txt mime = text/plain words = 4239 sentences = 247 flesch = 59 summary = Here, we develop a new mechanistic-statistical approach, based on a SIRD model (D being the dead cases compartment), in the aim of • estimating the effect of the lockdown in France on the contact rate and the effective reproduction number R e ; The computation of the solution of (1) with the posterior distribution of the parameters leads to a number of infectious I(t f ) = 7.0 · 10 5 and a total number of infected cases (including recovered) (I + R)(t f ) = 2.0 · 10 6 at the end of the observation period (April 14). We obtained an effective reproduction number that was divided by a factor 7, compared to the estimate of the R 0 carried out in France at the early stage of the epidemic, before the country went into lockdown [a value R 0 = 3.2 was obtained in (15) ]. cache = ./cache/cord-272085-4mqc8mqd.txt txt = ./txt/cord-272085-4mqc8mqd.txt === reduce.pl bib === id = cord-252950-eiphxwmn author = Trouillet-Assant, Sophie title = Type I IFN immunoprofiling in COVID-19 patients date = 2020-04-29 pages = extension = .txt mime = text/plain words = 1555 sentences = 118 flesch = 53 summary = COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous IFN-α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the immune response heterogeneity and opening avenues for targeted therapies. 42 Capsule summary: 43 COVID patients in ICU present a high mortality rate and immunoprofiling reveals heterogeneous α2 production with about 20% of critically-ill patients unable to produce IFN-α2, highlighting the 45 immune response heterogeneity and opening avenues for targeted therapies. Various immunosuppressive drugs, including IL-6 blockers or JAK-STAT signaling inhibitors have been 56 suggested for the treatment of SARS-COV-2 infection 2 whereas additional clinical trials are evaluating 57 the use of recombinant interferon to foster host antiviral response. To date, IFN-I response has not been evaluated in COVID-19 60 patients and its contribution to the viral control and inflammation is unknown. We further explored a larger cohort of 26 critically ill COVID patients from one of the intensive care 75 unit (ICU) at Hospices Civils de Lyon (Lyon, France). cache = ./cache/cord-252950-eiphxwmn.txt txt = ./txt/cord-252950-eiphxwmn.txt === reduce.pl bib === id = cord-021158-075vh5jg author = Fortané, Nicolas title = Antimicrobial resistance: preventive approaches to the rescue? Professional expertise and business model of French “industrial” veterinarians date = 2020-01-06 pages = extension = .txt mime = text/plain words = 12209 sentences = 563 flesch = 53 summary = Using recent debates on the AMR problem, it proposes to examine the relationship between the development of professional veterinary expertise and of the drug market, based on the case of a specific segment of the profession, namely veterinarians specializing in industrial poultry and pig production in western France. Indeed, it is common to hear professional organizations or public authorities state that in order to reduce their economic dependence on antibiotic sales, vets must rethink their activity by favouring preventive approaches to animal health which would involve a diversified range of services and would contribute to placing vets in an advisory role with a holistic vision of livestock farming or even of the food supply chain (VetFuturs France 2018) . cache = ./cache/cord-021158-075vh5jg.txt txt = ./txt/cord-021158-075vh5jg.txt === reduce.pl bib === id = cord-275827-r86ygqmy author = Lapeyre-Mestre, Maryse title = Addictovigilance contribution during COVID-19 epidemic and lockdown in France date = 2020-06-23 pages = extension = .txt mime = text/plain words = 5005 sentences = 217 flesch = 39 summary = In addition to this passive monitoring subject to under-reporting, other sources of information have been developed to improve vigilance: systematic data collection on falsified prescriptions from pharmacies ("ordonnances suspectes indicateur d'abus possible", OSIAP survey) [11, 12] and on secure prescription forms for narcotic drug prescriptions ( "antalgiques stupéfiants et ordonnances sécurisées", ASOS survey) [13] , systematic data collection from patients seen in addiction specialized structures ("observatoire des produits psychotropes illicites ou détournés de leur usage médicamenteux", OPPIDUM survey) [14] , analysis of toxicological data on chemical submission [15] or on deaths in a medico-legal framework ("décès en relation avec l'abus de médicaments et de substances", DRAMES survey) [16] . These early signals have been transmitted to national health authorities, leading to the implementation of a weekly specific monitoring of noteworthy cases or events related to the COVID-19, related to the lockdown, and of all falsified or abnormal prescription forms reported through the OSIAP survey during the period. cache = ./cache/cord-275827-r86ygqmy.txt txt = ./txt/cord-275827-r86ygqmy.txt === reduce.pl bib === id = cord-267867-q52nvn0n author = Chevalier, Christophe title = Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs date = 2016-12-14 pages = extension = .txt mime = text/plain words = 8001 sentences = 395 flesch = 48 summary = Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. We sought to determine whether the siRNAs si240-1a, si244, and si313, shown to be the most efficient in inhibiting the replication of HCV subgenomic replicons both transiently and under selective pressure, are also capable of efficiently blocking virus infection in cell culture. cache = ./cache/cord-267867-q52nvn0n.txt txt = ./txt/cord-267867-q52nvn0n.txt === reduce.pl bib === id = cord-288079-rr8h5dgy author = Prague, Melanie title = Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate date = 2020-04-24 pages = extension = .txt mime = text/plain words = 8628 sentences = 522 flesch = 58 summary = title: Population modeling of early COVID-19 epidemic dynamics in French regions and estimation of the lockdown impact on infection rate Combining several French public datasets on the early dynamics of the epidemic, we estimate region-specific key parameters conditionally on this mechanistic model through Stochastic Approximation Expectation Maximization (SAEM) optimization using Monolix software. While traditional compartment models do not account for spatiality, we propose to take it into account by: i) modeling the epidemic at a finer, more homogeneous geographical scale (this is particularly important once lockdown is in place); ii) by using a population approach with random effects across French regions which allows each region to have relatively different dynamics while taking all information into account for the estimation of model parameters iii) aligning the initial starting time of the epidemic for all regions. cache = ./cache/cord-288079-rr8h5dgy.txt txt = ./txt/cord-288079-rr8h5dgy.txt === reduce.pl bib === id = cord-257325-pvf0uon3 author = Zeitoun, Jean-David title = Impact of Local Care Environment and Social Characteristics on Aggregated Hospital-Fatality Rate from COVID-19 in France: Nationwide Observational Study date = 2020-10-10 pages = extension = .txt mime = text/plain words = 2371 sentences = 127 flesch = 53 summary = Objectives We aimed to investigate possible differences in aggregated hospital-fatality rate from COVID-19 in France at the early phase of the outbreak, and to determine whether factors related to population or healthcare supply before the pandemic could be associated with outcome differences. After multivariable analysis, four factors were independently associated with a significantly higher aggregated hospital-fatality rate: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001), and the ratio of people over 75 (estimate=0.91; p=0.0023). Apart from the population, four factors were independently associated with a significantly higher aggregated hospital-fatality rate from Covid-19: a higher ICU capacity at baseline (estimate=1.47; p=0.00791), a lower density of general practitioners (estimate=0.95; p=0.0205), a higher fraction of activity from the for-profit private sector (estimate=0.99; p<0.001) and the ratio of people over 75 (estimate=0.91; p=0.0023). cache = ./cache/cord-257325-pvf0uon3.txt txt = ./txt/cord-257325-pvf0uon3.txt === reduce.pl bib === id = cord-320636-mvtux07x author = Pullano, G. title = Underdetection of COVID-19 cases in France in the exit phase following lockdown date = 2020-08-12 pages = extension = .txt mime = text/plain words = 5252 sentences = 319 flesch = 48 summary = Using age-stratified transmission models parameterized to behavioral data and calibrated to regional hospital admissions, we estimated that 69,115 [58,072-77,449] COVID-19 symptomatic cases occurred, suggesting that 9 out of 10 cases with symptoms were not ascertained. In France, the surveillance strategy implemented by authorities to exit lockdown on May 11, 2020 was multifold 2,3 and based on an expanded case definition for COVID-19 suspect cases to guide clinical diagnosis 4 ; recommendations to the general population to seek healthcare even in presence of mild symptoms; prescription of diagnostic tests to suspect cases by general practitioners for systematic and comprehensive testing; isolation of confirmed cases and tracing of their contacts. Here we estimated the rate of detection of COVID-19 symptomatic cases in France in May-June 2020 after lockdown, through the use of virological and participatory syndromic surveillance data coupled with mathematical transmission models calibrated to regional hospitalizations. cache = ./cache/cord-320636-mvtux07x.txt txt = ./txt/cord-320636-mvtux07x.txt === reduce.pl bib === id = cord-014685-ihh30q6f author = nan title = Posters P788 - P999 date = 2005-09-21 pages = extension = .txt mime = text/plain words = 38354 sentences = 1784 flesch = 45 summary = This study has attempted to analyse the structural properties of membrane peptides and proteins through the use of model systems that have been designed to mimic their natural counterparts: Podlubnaya 2 1 Institute of Theoretical and Experimental Biophysics RAS, 2 Pushchino State University Amyloid brils are formed by proteins or their peptides in the result of a conformational transition from alpha helix into beta-sheet structure. Analysis of the results of such studies indicate that folding of SNase fragments is dominated by developing the local and non-local nucleation sites from native-like secondary structures and by intensifying the longrange interactions of residues at nucleation sites with residues further removed in sequence. The results show that at different pH values the aggregation processes of both proteins follow different pathways determined by the variations in the native structure and by the details of the involved conformational changes. cache = ./cache/cord-014685-ihh30q6f.txt txt = ./txt/cord-014685-ihh30q6f.txt === reduce.pl bib === id = cord-299846-yx18oyv6 author = Amar, Patrick title = Pandæsim: An Epidemic Spreading Stochastic Simulator date = 2020-09-18 pages = extension = .txt mime = text/plain words = 6358 sentences = 332 flesch = 56 summary = The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. The number of people of each age slice leaving their home sub-regions is a stochastic sample (or averaged value for the deterministic continuous solver) of a percentage of the population of this sub-region. Starting from an initial state (number of contagious people in each sub-region), the simulation algorithm iterates the following process at each timestep until either the epidemic ends or the maximum duration of the simulation is reached (defaults to 720 days). When the initial number of contagious people was relatively high, for example, in the Val-de-Marne sub-region (180), the results for both solvers were nearly identical: 5207 deaths for the average of 1000 stochastic runs and 5204 deaths for a deterministic run (Figures 2 and 3) . cache = ./cache/cord-299846-yx18oyv6.txt txt = ./txt/cord-299846-yx18oyv6.txt === reduce.pl bib === === reduce.pl bib === id = cord-314884-110nqkej author = Lansiaux, Édouard title = Covid-19 And Vit-D: Disease Mortality Negatively Correlates With Sunlight Exposure date = 2020-07-23 pages = extension = .txt mime = text/plain words = 1552 sentences = 97 flesch = 44 summary = In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. In the current study, we applied a Pearson correlation test to public health as well as weather data, in order to assess the linear relationship between COVID-19 mortality rate and the sunlight exposure. For instance in continental metropolitan France, average annual sunlight hours are significantly (for a p-value of 1.532x10 -32 ) correlated to the COVID-19 mortality rate, with a Pearson coefficient of -0.636. Specifically in the context of continental metropolitan France, the correlation between sunlight exposure and SARS-CoV-2 infection will be studied in this article, by using an adjusted Pearson test applied to public health and weather data [13] [14] [15] . cache = ./cache/cord-314884-110nqkej.txt txt = ./txt/cord-314884-110nqkej.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-016095-jop2rx61 author = Vignais, Pierre V. title = Challenges for Experimentation on Living Beings at the Dawn of the 21(st) Century date = 2010-06-08 pages = extension = .txt mime = text/plain words = 42843 sentences = 1503 flesch = 43 summary = Instead of setting out to discover unknown mechanisms by analyzing effects that are dependent on specific causes, with some uncertainty as to the possible success of the enterprise being undertaken, which is the foundation stone of the Bernardian paradigm of the experimental method, many current research projects give themselves achievable and programmable objectives that depend upon the means available to them: sequencing of genomes with a view to comparing them, recognition of sequence similarities in proteins coded for by genes belonging to different species, with the aim of putting together phylogenetic trees, synthesis of interesting proteins in transgenic animals and plants, analysis of the three-dimensional structure of proteins, in order to find sites that are likely to fix medicinal substances, and synthesis of molecular species able to recognize pathogenic targets. cache = ./cache/cord-016095-jop2rx61.txt txt = ./txt/cord-016095-jop2rx61.txt === reduce.pl bib === === reduce.pl bib === id = cord-318701-f9j13fsc author = Chamboredon, P. title = COVID‐19 pandemic in France: health emergency experiences from the field date = 2020-06-22 pages = extension = .txt mime = text/plain words = 4674 sentences = 224 flesch = 51 summary = On 12 March 2020, when WHO declared the status of a pandemic concerning the novel coronavirus (WHO 2020e), crisis measures were taken by the President of the French Republic (2020a) and his government, to control the epidemic and manage the health situation, namely, the closure of the nurseries, schools and universities for users as of 16 March 2020 ; the introduction of short-time work hours for employees whose companies cannot carry out their activities and of teleworking for all employees who have this possibility of adjusting the exercise of their profession (Ministry of Solidarity & Health 2020c). The health context made it possible to create the first telecare procedure related to the management of patients with COVID-19 by home nurses during the period of the state of health emergency (High Authority of Health 2020; Prime Minister of the French Government 2020c). cache = ./cache/cord-318701-f9j13fsc.txt txt = ./txt/cord-318701-f9j13fsc.txt === reduce.pl bib === id = cord-335297-vxhta6a4 author = Véran, Emilie title = Chyloabdomen in a cat with pancreatic carcinoma date = 2018-11-24 pages = extension = .txt mime = text/plain words = 2544 sentences = 179 flesch = 46 summary = Cases in dogs were reported in association with intestinal lymphangiectasia (Peterson, 1996) , mediastinal lymphangiosarcoma (Myers et al., 1966) , acute pancreatitis (Lott et al., 2015) , abdominal lymphatic rupture (Fossum et al., 1992) , complication of mesenteric lymphangiography for chylothorax (Fossum et al., 1992) , and lymphatic obstruction secondary to thrombus formation (Fossum et al., 1992) . A case of chylous pleural and peritoneal effusion with no underlying cause was described in a cat, with no postmortem examination performed (Thompson and Carr, 2002) . (2013) previously reported 34 feline cases of pancreatic carcinoma; chylous ascites was present in one cat in this series. By analogy, rutin has been unsuccessfully used in a case of chyloabdomen secondary to hypertrophic cardiomyopathy and a chylous pleural and peritoneal effusion with no underlying condition (Nelson, 2001; Thompson and Carr, 2002) . cache = ./cache/cord-335297-vxhta6a4.txt txt = ./txt/cord-335297-vxhta6a4.txt === reduce.pl bib === id = cord-320773-zisujjsx author = Sabat, Iryna title = United but divided: policy responses and people's perceptions in the EU during the COVID-19 outbreak date = 2020-06-22 pages = extension = .txt mime = text/plain words = 5637 sentences = 243 flesch = 50 summary = It was particularly pronounced for intrusive policy measures, such as mobile data use for movement tracking, economic concerns, and trust in the information from the national government. In order to understand the public sentiment towards the COVID-19 containment measures and to inform future policy development, we collected information on people's support for these policies, their worries in relation to the unfolding epidemic, and their trust in different sources of information. Overall, a north-south gradient could often be noticed in the EU regarding policy support: people living in the southern states (Portugal, Italy, and France) tended to approve of the containment policies more than residents in the northern countries (Denmark, Germany and the Netherlands). The first insights obtained from the data showed that containment and mitigating policies undertaken by national governments in response to the initial stages of the COVID-19 pandemic were generally wellreceived by the population in all countries covered by the survey. cache = ./cache/cord-320773-zisujjsx.txt txt = ./txt/cord-320773-zisujjsx.txt === reduce.pl bib === === reduce.pl bib === id = cord-253801-y1nherse author = Lepelletier, Didier title = Risque d’introduction et voies d’importation par l’homme de maladies infectieuses exotiques : cas particulier de l’émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l’occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l’étranger date = 2009-11-30 pages = extension = .txt mime = text/plain words = 2263 sentences = 212 flesch = 55 summary = title: Risque d'introduction et voies d'importation par l'homme de maladies infectieuses exotiques : cas particulier de l'émergence de bactéries pathogènes multirésistantes aux antibiotiques, importées en France à l'occasion de voyages internationaux ou du rapatriement de patients hospitalisés à l'étranger Le rapatriement sanitaire de français hospitalisés à l'étranger, mais aussi les simples retours de voyage et la prise en charge sanitaire d'étrangers en voyage en France, quelle que soit leur nationalité, expose donc la population française à des bactéries multirésistantes aux antibiotiques qui auraient pu être acquises dans des zones de haute prévalence de résistance. On sait toutefois qu'il est réel et des évènements sporadiques ou épidémiques ont été observés concernant des pathogènes tels que Mycobacterium tuberculosis multirésistant, Clostridium difficile de ribotype 027, Klebsiella pneumoniae productrice de carbapénèmase, Acinetobacter baumannii multirésistant, Staphylococcus aureus résistant à la méticilline commu-Bull. cache = ./cache/cord-253801-y1nherse.txt txt = ./txt/cord-253801-y1nherse.txt === reduce.pl bib === id = cord-331509-p19dg1jw author = Bigault, Lionel title = Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR date = 2020-05-31 pages = extension = .txt mime = text/plain words = 4317 sentences = 240 flesch = 60 summary = title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. For a rapid, accurate and reliable diagnosis of PED in the veterinary laboratory, a method for the detection of PEDV viral RNA has been developed and more importantly validated according to the "Association Francaise de NORmalisation" (AFNOR) French NF U47-600 norm entitled "requirement and recommendation for the implementation, development and validation of PCR in animal health" (AFNOR, 2015a; AFNOR, 2015b) . This method should help harmonize detection and quantification of viral RNA from PEDV belonging to both S-non-INDEL and S-INDEL strains in both field and experimental settings. cache = ./cache/cord-331509-p19dg1jw.txt txt = ./txt/cord-331509-p19dg1jw.txt === reduce.pl bib === === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-339820-x8r27w14 author = Guan, L. title = Transport effect of COVID-19 pandemic in France date = 2020-07-29 pages = extension = .txt mime = text/plain words = 5388 sentences = 379 flesch = 61 summary = 50 Based on regional model analysis before and after the lockdown, we present a network model to characterize the pandemic transmission between regions in France after lockdown and evaluate the transport effect of COVID-19 pandemic, when considering all age classes together. In this section, regional scales of France are considered and all age classes are summed to calibrate the parameters of the pandemic model (6)-(13) during 12 All rights reserved. In this section, the general form of an integro-differential model capable of integrating different age classes and areas is introduced to discuss the transport effect of COVID-19 in France after lockdown. . https://doi.org/10.1101/2020.07.27.20161430 doi: medRxiv preprint Equation (40) describes the network dynamics of COVID-19 pandemic after lockdown and the transport effect on different age class on the basis of the regional pandemic transmission dynamics during lockdown. cache = ./cache/cord-339820-x8r27w14.txt txt = ./txt/cord-339820-x8r27w14.txt === reduce.pl bib === === reduce.pl bib === id = cord-344020-8poerd09 author = Vermeulen, Tom D title = Autochthonous dengue in two Dutch tourists visiting Département Var, southern France, July 2020 date = 2020-10-01 pages = extension = .txt mime = text/plain words = 1827 sentences = 110 flesch = 54 summary = We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. We report dengue virus (DENV) infection in two Dutch tourists who visited Département Var, southern France, in July and August 2020. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. As some autochthonous dengue cases have occurred in Europe in recent years, awareness among physicians and public health experts about possible intermittent presence of DENV in southern Europe is important to minimise delay in diagnosis and treatment. On August 27, upon confirmation of the serological results, Patient 1 was reported by the RIVM to the French authorities through the Early Warning and Response System of the European Union as an autochthonous DENV infection probably acquired in France with cross-border implication. cache = ./cache/cord-344020-8poerd09.txt txt = ./txt/cord-344020-8poerd09.txt === reduce.pl bib === id = cord-015334-8p124rwp author = nan title = ESCP 36th European Symposium on Clinical Pharmacy ‘Implementing Clinical Pharmacy in Community and Hospital Settings: Sharing the Experience’, Istanbul, Turkey 25–27 October 2007; Abstracts date = 2008-06-11 pages = extension = .txt mime = text/plain words = 51143 sentences = 3291 flesch = 51 summary = Based on the results of the pharmacoeconomic analysis, development of clinical pharmacy and CIVAS for some drugs will be discussed with the paediatric department Background and Objective: Studies show that up to 38% of patients starting treatment with antidepressants fill only a single prescription at the pharmacy, apparently not accepting treatment. Main Outcome Measures: Data collected were: nurses' profile (age, length of service, competencies' self-assessment), knowledge on drugs prescribed to their patients (usage, administration, side-effects, drug interactions…), use of existing tools (i.e. drugs database) and possible tools to be developed by the pharmacy ward to help them in their daily practice. The objectives were:(1)To identify the most relevant minor ailments, agreeing on the specific criteria for referral to the GP.(2)To select the non-prescription drugs, with evidence of safety and effectiveness, for the treatment of the identified minor ailments Design: Qualitative study with an expert panel which was made up of 2 primary care physician from SEMFYC and six community pharmacists (two members of SEFAC and four members of GIAF-UGR). cache = ./cache/cord-015334-8p124rwp.txt txt = ./txt/cord-015334-8p124rwp.txt === reduce.pl bib === id = cord-337744-g17qe8fi author = Pullano, G. title = Population mobility reductions during COVID-19 epidemic in France under lockdown date = 2020-06-01 pages = extension = .txt mime = text/plain words = 6646 sentences = 390 flesch = 52 summary = Lockdown caused a 65% reduction in countrywide number of displacements, and was particularly effective in reducing work-related short-range mobility, especially during rush hours, and recreational long-range trips. Accurately measuring changes in human mobility under these restrictions is essential to (i) quantitatively determine how imposed measures and recommendations (e.g. regarding telework where possible, ban of leisure trips) translated into reduced mobility at specific scales and times, (ii) inform models estimating the effectiveness of the ongoing lockdown in reducing the epidemic spread 3,4 , (iii) help devising social distancing measures needed for the post-lockdown phase. The impact of nationwide lockdown in the reduction of outgoing mobility per region was strongly associated with the fraction of the population in the most active age range (24-59 y.o.) 24 (Pearson r = 0.91, p < 0.01) and the fraction of workers employed in sectors that substantially modified their organization during lockdown, due to telework, partial or full closure of activities (Pearson r = 0.80, p < 0.01) (Table 1 and Figure 4) . cache = ./cache/cord-337744-g17qe8fi.txt txt = ./txt/cord-337744-g17qe8fi.txt === reduce.pl bib === id = cord-335252-med3c01q author = Fovet, Thomas title = Prisons confinées: quelles conséquences pour les soins psychiatriques et la santé mentale des personnes détenues en France? date = 2020-05-08 pages = extension = .txt mime = text/plain words = 3647 sentences = 303 flesch = 52 summary = L'objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d'interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L'objectif de cet article est de décrire la réorganisation des soins psychiatriques en milieu pénitentiaire en contexte de pandémie de Covid-19 et d'interroger les conséquences du confinement et des libérations anticipées sur la santé mentale des personnes détenues. L'épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important. L'épidémie de Covid-19 semble avoir été plutôt contenue dans les prisons françaises au cours de la période de confinement mais le poids des mesures mises en place sur la population carcérale est important. cache = ./cache/cord-335252-med3c01q.txt txt = ./txt/cord-335252-med3c01q.txt === reduce.pl bib === id = cord-340298-0l4pec0z author = Terriau, A. title = Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model date = 2020-05-01 pages = extension = .txt mime = text/plain words = 3971 sentences = 257 flesch = 55 summary = title: Impact of virus testing on COVID-19 case fatality rate: estimate using a fixed-effects model Methods We use data on inpatients across French geographic areas and propose a novel methodology that exploits policy discontinuities at region borders to estimate the effect of COVID-19 tests on the case-fatality rate. Screening policies and mortality rate might be related to the fact that testing allows authorities to detect and isolate infected people and to prevent them from transmitting the virus; and also enables early treatment, thus increasing the chances of cure. We used a fixed-effects model to assess the impact of the number of tests performed over time at a local geographical level (department) on fatality-cases. Our strategy consisted in comparing all contiguous department pairs sharing a region border (See Figure 1 for an example) to identify the effect of testing on the case fatality rate. cache = ./cache/cord-340298-0l4pec0z.txt txt = ./txt/cord-340298-0l4pec0z.txt === reduce.pl bib === id = cord-355549-6xnjj5h5 author = Cécile, Couchoud title = Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date = 2020-08-25 pages = extension = .txt mime = text/plain words = 4006 sentences = 211 flesch = 50 summary = The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. The aim of this first report from the French REIN registry is to describe the population of infected dialysis patients and their course of illness, estimate the incidence and lethality of COVID-19 disease and identify the risk factors associated with the probability of death. This can also be associated with the implementation of all the necessary preventive actions prone by the SFNDT, including 1/wearing a mask during transport and for the entire period of care, 2/systematic tracking of patients and screening at the entrance to dialysis units based on fever and symptoms or contact with an infected person and 3/restricting areas for COVID-19 cases (18),. cache = ./cache/cord-355549-6xnjj5h5.txt txt = ./txt/cord-355549-6xnjj5h5.txt === reduce.pl bib === id = cord-004534-jqm1hxps author = nan title = Abstract date = 2009-06-09 pages = extension = .txt mime = text/plain words = 139023 sentences = 6450 flesch = 42 summary = HIV-1 to efficiently complete a replication cycle has to integrate its genome into the host cellular DNA.After HIV-1 enters target cells,neosynthesized viral DNA forms along with other proteins the pre-integration complex (PIC).PICs are then transported into the nucleus where integration,catalyzed by the viral integrase,takes place.HIV-1 viral particles engineered to incorporate integrase fused to EGFP have proven effective to study PICs within nuclei of infected cells.In this study we report the live imaging analysis of nuclear PIC dynamics obtained by time-lapse microscopy.Intranuclear trajectories of IN-EGFP-labeled PIC were collected in three dimensions and examined by both mean squared displacement (MSD) and cage diameter (CD) analysis.In CD the maximum distances measured between two positions occupied by a PIC in a time window of 2 minutes were calculated while in our MSD analysis 5-minute long trajectory segments were considered.Remarkably,MSD revealed the presence of an underlying active transport mechanism.To test the possible role of actin filaments,PIC nuclear trafficking was analyzed in cells treated with latrunculin B (actin polymerization inhibitor).Preliminary results suggest that the disruption of actin function impairs the active nuclear movement of PICs. Second harmonic generation microscopy reveals sarcomere contractile dynamics of cardiomyocytes N. cache = ./cache/cord-004534-jqm1hxps.txt txt = ./txt/cord-004534-jqm1hxps.txt === reduce.pl bib === === reduce.pl bib === id = cord-350571-6tapkjb6 author = nan title = 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 date = 2017-01-10 pages = extension = .txt mime = text/plain words = 106013 sentences = 6203 flesch = 48 summary = Possible solutions might be to use shared communication tools like Internet based communication programs and to introduce the patient as a participant at the IMRs. Please specify your abstract type: Research abstract Background and objective: International good pharmacy practice guidelines describe how pharmacists should counsel the patients about their medicines, offer additional services where needed, and intervene at drug related problems. Please specify your abstract type: Descriptive abstract (for projects) Background and objective: In order to improve the medication reconciliation and to implement training programs for the medical team in an associated to general hospital nursing (ASNH) home we measured the discrepancies between pharmacy registered treatments (PRT) and medical prescriptions (MP), and we analysed potentially inappropriate prescriptions according to ''American Geriatrics Society 2015 Beers Criteria'' and ''STOPP-START 2014 criteria. cache = ./cache/cord-350571-6tapkjb6.txt txt = ./txt/cord-350571-6tapkjb6.txt === reduce.pl bib === id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 pages = extension = .txt mime = text/plain words = 102485 sentences = 7028 flesch = 52 summary = Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). cache = ./cache/cord-355038-o2hr5mox.txt txt = ./txt/cord-355038-o2hr5mox.txt === reduce.pl bib === id = cord-023049-fio7cjj5 author = nan title = 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain date = 2017-06-22 pages = extension = .txt mime = text/plain words = 145485 sentences = 7436 flesch = 48 summary = Clinical efficacy (Medical Research Council sum score, 10-m walk, modified Inflammatory Neuropathy Cause and Treatment score, Overall Neuropathy Limitations Scale, Romberg test) and patient-reported outcomes (36-item Short Form Health Survey , Life Quality Index [LQI] ) were assessed at baseline and at regular intervals until the final visit (10-14 months after switching). To explore the issue of early biomarkers in FAP, we performed skin biopsy and compared IENF density with parameters of nerve conduction studies (NCS) and quantitative sensory testing (QST) on 36 subjects (23 men, aged 55.1 ± 11.1 years) with genetic confirmation of TTR-A97S: 17 patients and 19 carriers. Results: The Gly112Ser mutation causing CMT1C is a mild form of CMT, as patients walked on time, had less weakness than those with Charcot-Marie-Tooth Disease type 1A (CMT1A), had a Charcot Marie Tooth neuropathy score (CMTNS) indicative of mild disease, and had faster ulnar and median motor nerve conduction velocities compared to those with CMT1A. cache = ./cache/cord-023049-fio7cjj5.txt txt = ./txt/cord-023049-fio7cjj5.txt === reduce.pl bib === id = cord-007890-bie1veti author = nan title = ECC-4 Abstracts date = 2002-04-16 pages = extension = .txt mime = text/plain words = 85992 sentences = 5665 flesch = 50 summary = Effects of Interferon alpha plus ribavirine therapy on frequencies of HCV, HIV and CMV specific CD4-T-cell responses in peripheral blood of HIV/HCV coinfected patients after 6 months of treatment SoA9.5 Methods: Two groups of patients with chronic HCV infection were studied: 26 HIV coinfected progressors with antiretroviral therapy and 13 HIV-negative controls. In order to assess the local temporal trend of antibiotic sensitivity of the most common urinary tract bacterial pathogen, all urine-cultured Escherichia coli isolates were reviewed as to susceptibility profile, and specimen source (community-versus hospital-acquired infection). Methods: A total of 87 penicillin resistant clinical strains isolated from patients at Hacettepe Children's Hospital, Ankara, Turkey between 1999 and 2001 were tested for their in vitro susceptibility to various antibiotics that are commonly used in the treatment of respiratory tract infections. cache = ./cache/cord-007890-bie1veti.txt txt = ./txt/cord-007890-bie1veti.txt ===== Reducing email addresses cord-014538-6a2pviol cord-004534-jqm1hxps cord-355038-o2hr5mox Creating transaction Updating adr table ===== Reducing keywords cord-000425-isw6jeir cord-284616-jgtsl06q cord-262046-bb8ekgdm cord-285187-1h5tjs0r cord-264203-7dnz9yaa cord-252950-eiphxwmn cord-272085-4mqc8mqd cord-021158-075vh5jg cord-275827-r86ygqmy cord-267867-q52nvn0n cord-288079-rr8h5dgy cord-257325-pvf0uon3 cord-320636-mvtux07x cord-014685-ihh30q6f cord-299846-yx18oyv6 cord-322943-lvdl7puw cord-296081-6coxz3l8 cord-314884-110nqkej cord-319418-ao0df0q7 cord-016095-jop2rx61 cord-335297-vxhta6a4 cord-318701-f9j13fsc cord-292475-jrl1fowa cord-320773-zisujjsx cord-282095-cbfyydi3 cord-253801-y1nherse cord-014538-6a2pviol cord-331509-p19dg1jw cord-335215-h9p4kmss cord-344020-8poerd09 cord-344984-mg779mix cord-339820-x8r27w14 cord-015334-8p124rwp cord-335252-med3c01q cord-337744-g17qe8fi cord-355549-6xnjj5h5 cord-347244-abxv2mkz cord-004534-jqm1hxps cord-340298-0l4pec0z cord-355038-o2hr5mox cord-023049-fio7cjj5 cord-350571-6tapkjb6 cord-007890-bie1veti Creating transaction Updating wrd table ===== Reducing urls cord-264203-7dnz9yaa cord-285187-1h5tjs0r cord-000425-isw6jeir cord-272085-4mqc8mqd cord-275827-r86ygqmy cord-288079-rr8h5dgy cord-320636-mvtux07x cord-014685-ihh30q6f cord-322943-lvdl7puw cord-296081-6coxz3l8 cord-319418-ao0df0q7 cord-335297-vxhta6a4 cord-292475-jrl1fowa cord-282095-cbfyydi3 cord-339820-x8r27w14 cord-344984-mg779mix cord-337744-g17qe8fi cord-340298-0l4pec0z cord-355549-6xnjj5h5 cord-004534-jqm1hxps cord-350571-6tapkjb6 Creating transaction Updating url table ===== Reducing named entities cord-284616-jgtsl06q cord-000425-isw6jeir cord-262046-bb8ekgdm cord-285187-1h5tjs0r cord-264203-7dnz9yaa cord-252950-eiphxwmn cord-272085-4mqc8mqd cord-021158-075vh5jg cord-275827-r86ygqmy cord-267867-q52nvn0n cord-288079-rr8h5dgy cord-257325-pvf0uon3 cord-320636-mvtux07x cord-299846-yx18oyv6 cord-322943-lvdl7puw cord-314884-110nqkej cord-319418-ao0df0q7 cord-296081-6coxz3l8 cord-318701-f9j13fsc cord-335297-vxhta6a4 cord-292475-jrl1fowa cord-320773-zisujjsx cord-282095-cbfyydi3 cord-014685-ihh30q6f cord-016095-jop2rx61 cord-253801-y1nherse cord-331509-p19dg1jw cord-335215-h9p4kmss cord-339820-x8r27w14 cord-344984-mg779mix cord-344020-8poerd09 cord-335252-med3c01q cord-337744-g17qe8fi cord-340298-0l4pec0z cord-355549-6xnjj5h5 cord-347244-abxv2mkz cord-014538-6a2pviol cord-015334-8p124rwp cord-350571-6tapkjb6 cord-355038-o2hr5mox cord-007890-bie1veti cord-004534-jqm1hxps cord-023049-fio7cjj5 Creating transaction Updating ent table ===== Reducing parts of speech cord-284616-jgtsl06q cord-262046-bb8ekgdm cord-252950-eiphxwmn cord-285187-1h5tjs0r cord-000425-isw6jeir cord-272085-4mqc8mqd cord-257325-pvf0uon3 cord-314884-110nqkej cord-319418-ao0df0q7 cord-275827-r86ygqmy cord-296081-6coxz3l8 cord-267867-q52nvn0n cord-320636-mvtux07x cord-322943-lvdl7puw cord-299846-yx18oyv6 cord-264203-7dnz9yaa cord-021158-075vh5jg cord-288079-rr8h5dgy cord-318701-f9j13fsc cord-335297-vxhta6a4 cord-320773-zisujjsx cord-253801-y1nherse cord-331509-p19dg1jw cord-292475-jrl1fowa cord-282095-cbfyydi3 cord-335215-h9p4kmss cord-339820-x8r27w14 cord-344020-8poerd09 cord-344984-mg779mix cord-335252-med3c01q cord-355549-6xnjj5h5 cord-340298-0l4pec0z cord-347244-abxv2mkz cord-337744-g17qe8fi cord-014685-ihh30q6f cord-016095-jop2rx61 cord-015334-8p124rwp cord-014538-6a2pviol cord-007890-bie1veti cord-355038-o2hr5mox cord-350571-6tapkjb6 cord-004534-jqm1hxps cord-023049-fio7cjj5 Creating transaction Updating pos table Building ./etc/reader.txt cord-007890-bie1veti cord-023049-fio7cjj5 cord-350571-6tapkjb6 cord-355038-o2hr5mox cord-350571-6tapkjb6 cord-014538-6a2pviol number of items: 43 sum of words: 900,336 average size in words: 25,723 average readability score: 50 nouns: patients; study; results; treatment; data; cases; time; care; protein; number; cells; analysis; patient; years; cell; age; drug; disease; group; use; hospital; model; days; rate; risk; studies; nerve; conclusion; type; membrane; therapy; mortality; infection; outcome; methods; health; period; proteins; drugs; case; system; medication; method; information; measures; effect; activity; changes; effects; population verbs: using; shown; include; associated; increased; compared; performing; identifying; based; following; report; find; study; observed; developed; assessed; evaluating; suggesting; received; related; determined; making; provided; treating; leading; present; take; obtained; considering; investigate; according; reduce; requires; allows; describe; induced; involved; giving; known; improve; remains; caused; measured; bound; decreasing; tested; detected; defined; collected; occurred adjectives: clinical; different; high; first; non; new; acute; main; significant; specific; higher; severe; medical; positive; low; anti; molecular; mean; respiratory; single; several; important; abstract; intensive; common; early; human; possible; resistant; peripheral; lower; therapeutic; french; large; available; median; similar; patient; sensory; antibiotic; chronic; small; total; potential; many; present; mechanical; major; negative; second adverbs: also; however; well; respectively; significantly; therefore; even; often; still; previously; highly; especially; mainly; recently; frequently; particularly; less; now; critically; moreover; finally; least; already; currently; furthermore; first; together; prior; strongly; directly; independently; clinically; later; far; almost; commonly; rather; potentially; indeed; usually; nevertheless; mostly; much; fully; relatively; n't; yet; better; statistically; rapidly pronouns: we; it; our; their; its; they; them; i; your; he; us; his; she; her; you; itself; themselves; my; one; him; me; himself; ourselves; igg4; u; pbp; mg; s; ours; ncs-4; imagej; esat-6; ĝ; yourself; uhfus; themself; theirs; t)dy; pm230; oneself; olhf).the; n=9; myself; ka.max; itg2a+; https://doi.org/10.1101/2020.08; herself; g)and; facieum; cord-322943-lvdl7puw proper nouns: France; ICU; University; mg; Hospital; _; CIDP; Department; C; S.; GBS; Italy; C.; RNA; COVID-19; CMT; M; Institute; A; M.; HCV; L; E.; A.; S; T; Germany; Medical; P.; January; DNA; ARDS; J.; HIV; Health; USA; E; B; D; ±; II; May; CI; K; J; March; National; L.; Fig; VAP keywords: france; covid-19; study; university; patient; rna; french; result; hospital; medicine; italy; institute; department; care; protein; january; icu; hcv; drug; dna; cell; vap; treatment; structure; research; prescription; pharmacy; pharmacist; objective; number; niv; mortality; membrane; medical; june; japan; international; ifn; hiv; high; group; ecmo; drp; day; conclusion; clinical; case; background; atp; ards one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146468/ titles(s): Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation three topics; one dimension: patients; protein; patients file(s): https://www.ncbi.nlm.nih.gov/pubmed/28074393/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079852/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166380/ titles(s): 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 | Abstract | 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain five topics; three dimensions: patients study results; protein cells membrane; patients nerve neuropathy; patients strains resistance; covid france number file(s): https://www.ncbi.nlm.nih.gov/pubmed/28074393/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079852/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166380/, https://www.sciencedirect.com/science/article/pii/S0001407919324185, https://www.ncbi.nlm.nih.gov/pubmed/21055855/ titles(s): 45th ESCP-NSF international symposium on clinical pharmacy: clinical pharmacy tackling inequalities and access to health care. Oslo, Norway, 5–7 October 2016 | Abstract | 2017 Peripheral Nerve Society Meeting July 8–12, 2017 Sitges, Barcelona, Spain | Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse | The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness Type: cord title: keyword-france-cord date: 2021-05-24 time: 23:51 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:france ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-292475-jrl1fowa author: Abry, Patrice title: Spatial and temporal regularization to estimate COVID-19 reproduction number R(t): Promoting piecewise smoothness via convex optimization date: 2020-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Among the different indicators that quantify the spread of an epidemic such as the on-going COVID-19, stands first the reproduction number which measures how many people can be contaminated by an infected person. In order to permit the monitoring of the evolution of this number, a new estimation procedure is proposed here, assuming a well-accepted model for current incidence data, based on past observations. The novelty of the proposed approach is twofold: 1) the estimation of the reproduction number is achieved by convex optimization within a proximal-based inverse problem formulation, with constraints aimed at promoting piecewise smoothness; 2) the approach is developed in a multivariate setting, allowing for the simultaneous handling of multiple time series attached to different geographical regions, together with a spatial (graph-based) regularization of their evolutions in time. The effectiveness of the approach is first supported by simulations, and two main applications to real COVID-19 data are then discussed. The first one refers to the comparative evolution of the reproduction number for a number of countries, while the second one focuses on French departments and their joint analysis, leading to dynamic maps revealing the temporal co-evolution of their reproduction numbers. url: https://www.ncbi.nlm.nih.gov/pubmed/32817697/ doi: 10.1371/journal.pone.0237901 id: cord-299846-yx18oyv6 author: Amar, Patrick title: Pandæsim: An Epidemic Spreading Stochastic Simulator date: 2020-09-18 words: 6358.0 sentences: 332.0 pages: flesch: 56.0 cache: ./cache/cord-299846-yx18oyv6.txt txt: ./txt/cord-299846-yx18oyv6.txt summary: The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. The number of people of each age slice leaving their home sub-regions is a stochastic sample (or averaged value for the deterministic continuous solver) of a percentage of the population of this sub-region. Starting from an initial state (number of contagious people in each sub-region), the simulation algorithm iterates the following process at each timestep until either the epidemic ends or the maximum duration of the simulation is reached (defaults to 720 days). When the initial number of contagious people was relatively high, for example, in the Val-de-Marne sub-region (180), the results for both solvers were nearly identical: 5207 deaths for the average of 1000 stochastic runs and 5204 deaths for a deterministic run (Figures 2 and 3) . abstract: SIMPLE SUMMARY: In order to study the efficiency of countermeasures used against the Covid-19 pandemic at the scale of a country, we designed a model and developed an efficient simulation program based on a well known discrete stochastic simulation framework along with a standard, coarse grain, spatial localisation extension. Our particular approach allows us also to implement deterministic continuous resolutions of the same model. We applied it to the Covid-19 epidemic in France where lockdown countermeasures were used. With the stochastic discrete method, we found good correlations between the simulation results and the statistics gathered from hospitals. In contrast, the deterministic continuous approach lead to very different results. We proposed an explanation based on the fact that the effects of discretisation are high for small values, but low for large values. When we add stochasticity, it can explain the differences in behaviour of those two approaches. This system is one more tool to study different countermeasures to epidemics, from lockdowns to social distancing, and also the effects of mass vaccination. It could be improved by including the possibility of individual reinfection. ABSTRACT: Many methods have been used to model epidemic spreading. They include ordinary differential equation systems for globally homogeneous environments and partial differential equation systems to take into account spatial localisation and inhomogeneity. Stochastic differential equations systems have been used to model the inherent stochasticity of epidemic spreading processes. In our case study, we wanted to model the numbers of individuals in different states of the disease, and their locations in the country. Among the many existing methods we used our own variant of the well known Gillespie stochastic algorithm, along with the sub-volumes method to take into account the spatial localisation. Our algorithm allows us to easily switch from stochastic discrete simulation to continuous deterministic resolution using mean values. We applied our approaches on the study of the Covid-19 epidemic in France. The stochastic discrete version of Pandæsim showed very good correlations between the simulation results and the statistics gathered from hospitals, both on day by day and on global numbers, including the effects of the lockdown. Moreover, we have highlighted interesting differences in behaviour between the continuous and discrete methods that may arise in some particular conditions. url: https://www.ncbi.nlm.nih.gov/pubmed/32962157/ doi: 10.3390/biology9090299 id: cord-331509-p19dg1jw author: Bigault, Lionel title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR date: 2020-05-31 words: 4317.0 sentences: 240.0 pages: flesch: 60.0 cache: ./cache/cord-331509-p19dg1jw.txt txt: ./txt/cord-331509-p19dg1jw.txt summary: title: Porcine epidemic diarrhea virus: Viral RNA detection and quantification using a validated one-step real time RT-PCR In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. For a rapid, accurate and reliable diagnosis of PED in the veterinary laboratory, a method for the detection of PEDV viral RNA has been developed and more importantly validated according to the "Association Francaise de NORmalisation" (AFNOR) French NF U47-600 norm entitled "requirement and recommendation for the implementation, development and validation of PCR in animal health" (AFNOR, 2015a; AFNOR, 2015b) . This method should help harmonize detection and quantification of viral RNA from PEDV belonging to both S-non-INDEL and S-INDEL strains in both field and experimental settings. abstract: Since 2014, porcine epidemic diarrhea virus (PEDV) has reemerged in Europe. RT-PCR methods have been described for the detection of PEDV, but none have been validated according to a norm. In this study we described the development and validation of a SYBR™ Green one-step RT-qPCR according to the French norm NF U47-600, for the detection and quantification of PEDV viral RNA. The method was validated from sample preparation (feces or jejunum) through to nucleic acid extraction and RT-qPCR detection. Specificity and sensitivity, limit of detection (LoD), limit of quantification (LQ), linearity, intra and inter assay variability were evaluated using transcribed RNA and fecal and jejunum matrices spiked with virus. The analytical and diagnostic specificities and sensitivities of this RT-qPCR were 100% in this study. A LoD of 50 genome copies/5 µl of extract from fecal matrices spiked with virus or RNA transcript and 100 genome copies/5 µl of extract from jejunum matrices spiked with virus were obtained. The Lower LQ (LLQ) was 100 genome copies/5 µl and the Upper LQ (ULQ) 10(8) copies/5 µl. This method is the first, validated according a norm for PEDV and may serve as a global reference method to harmonize detection and quantification of PEDV viral RNA in both field and experimental settings. url: https://www.sciencedirect.com/science/article/pii/S0166093420301580?v=s5 doi: 10.1016/j.jviromet.2020.113906 id: cord-344984-mg779mix author: Bitar, Dounia title: Risques d’importation des maladies infectieuses exotiques en France métropolitaine : détection, alerte et réponse date: 2009-11-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: SUMMARY The French public health institute is responsible for promoting and coordinating threats the detection and assessment of health risks, and for suggesting possible responses. Transmissible diseases affecting both human and animal health are the focus of surveillance networks. Early detection of potential infectious threats is based on the screening of “ alert signals “ identified through routine surveillance networks and other systems. The quality and accuracy of these signals is first verified, before assessing, through a multidisciplinary approach, the risk of introduction and dissemination. This article examines specific cases illustrating the process of detection, risk analysis and response, with respect to infectious threats that are endemic in tropical regions and have the potential to be imported into metropolitan France. For both novel pathogens and exotic diseases — which, not being endemic in France, are less well known — the analysis and response process must regularly be adapted to the latest epidemiological, clinical and biological findings, taking interactions between the pathogen, host, and environment into consideration. The need to improve reaction times and risk assessment is also discussed. url: https://www.sciencedirect.com/science/article/pii/S0001407919324185 doi: 10.1016/s0001-4079(19)32418-5 id: cord-318701-f9j13fsc author: Chamboredon, P. title: COVID‐19 pandemic in France: health emergency experiences from the field date: 2020-06-22 words: 4674.0 sentences: 224.0 pages: flesch: 51.0 cache: ./cache/cord-318701-f9j13fsc.txt txt: ./txt/cord-318701-f9j13fsc.txt summary: On 12 March 2020, when WHO declared the status of a pandemic concerning the novel coronavirus (WHO 2020e), crisis measures were taken by the President of the French Republic (2020a) and his government, to control the epidemic and manage the health situation, namely, the closure of the nurseries, schools and universities for users as of 16 March 2020 ; the introduction of short-time work hours for employees whose companies cannot carry out their activities and of teleworking for all employees who have this possibility of adjusting the exercise of their profession (Ministry of Solidarity & Health 2020c). The health context made it possible to create the first telecare procedure related to the management of patients with COVID-19 by home nurses during the period of the state of health emergency (High Authority of Health 2020; Prime Minister of the French Government 2020c). abstract: AIM: This paper describes the situation regarding COVID‐19 emergency in France as of early May 2020, the main policies to fight this virus, and the roles and responsibilities of nurses regarding their work at this time, as well as the challenges facing the profession. BACKGROUND: Europe continues to be affected by the COVID‐19 pandemic. At the time of writing France was the fourth country with the highest number of detected cases and cumulative deaths. SOURCES OF EVIDENCE: Websites of the World Health Organization, French Government, French Agency of Public Health, French National Council of Nurses and ClinicalTrials.gov database, as well as the experiences of the authors. DISCUSSION: The history of the development of the pandemic in France helps explain the establishment of the state of health emergency and containment of the population. Many decisions made had undesirable repercussions, particularly in terms of intra‐family violence, mental health disorders and the renunciation of care. Hospitals and primary care services, with significant investment by nurses, played a key role in the care of persons with and without COVID‐19. CONCLUSION: France has suffered a very high toll in terms of COVID‐19 morbidity and mortality, and effects on its people, health systems and health professionals, including nurses. IMPLICATIONS FOR NURSING PRACTICE: Nurses are recognized for their social usefulness in France. However, it is important to consider the collateral effects of this crisis on nurses and nursing and to integrate the health emergency nursing skills established during the pandemic into the standard field of nursing competence. IMPLICATIONS FOR NURSING POLICY: The nursing profession has expectations of a reflection on and revision of nursing skills as well as of its valorization in the French healthcare system, notably carried out by the French National Council Order of Nurses. url: https://www.ncbi.nlm.nih.gov/pubmed/32567057/ doi: 10.1111/inr.12604 id: cord-267867-q52nvn0n author: Chevalier, Christophe title: Inhibition of Hepatitis C Virus Infection in Cell Culture by Small Interfering RNAs date: 2016-12-14 words: 8001.0 sentences: 395.0 pages: flesch: 48.0 cache: ./cache/cord-267867-q52nvn0n.txt txt: ./txt/cord-267867-q52nvn0n.txt summary: Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. We sought to determine whether the siRNAs si240-1a, si244, and si313, shown to be the most efficient in inhibiting the replication of HCV subgenomic replicons both transiently and under selective pressure, are also capable of efficiently blocking virus infection in cell culture. abstract: Hepatitis C virus (HCV) infection is a major cause of chronic liver disease and hepatocellular carcinoma, yet fully efficacious treatments are missing. In this study, we investigated RNA interference (RNAi), a specific gene silencing process mediated by small interfering RNA (siRNA) duplexes, as an antiviral strategy against HCV. Synthetic siRNAs were designed to target conserved sequences of the HCV 5′ nontranslated region (NTR) located in a functional, stem–loop structured domain of the HCV internal ribosome entry site (IRES), which is crucial for initiation of polyprotein translation. Several siRNAs dramatically reduced or even abrogated the replication of selectable subgenomic HCV replicons upon cotransfection of human hepatoma cells with viral target and siRNAs, or upon transfection of cells supporting autonomous replication of HCV replicon with siRNAs. Importantly, three siRNAs also proved capable of strongly inhibiting virus production in cell culture. One siRNA, targeting a sequence that is highly conserved across all genotypes and forms a critical pseudoknot structure involved in translation, was identified as the most promising therapeutic candidate. These results indicate that the HCV life cycle can be efficiently blocked by using properly-designed siRNAs that target functionally important, highly conserved sequences of the HCV IRES. This finding offers a novel approach towards developing IRES-based antiviral treatment for chronic HCV infections. url: https://www.sciencedirect.com/science/article/pii/S152500161632439X doi: 10.1038/sj.mt.6300186 id: cord-319418-ao0df0q7 author: Chire Saire, J. E. title: Study of Coronavirus Impact on Parisian Population from April to June using Twitter and Text Mining Approach date: 2020-08-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The fast spreading of coronavirus name covid19, generated the actual pandemic forcing to change daily activities. Health Councils of each country promote health policies, close borders and start a partial or total lockdown. One of the first countries in Europe with high impact was Italy. Besides at the end of April, one country with a shared border was on the top of 10 countries with more total cases, then France started with its own battle to beat coronavirus. This paper studies the impact of coronavirus in the poopulation of Paris, France from April 23 to June 18, using Text Mining approach, processing data collected from Social Network and using trends related of searching. First finding is a decreasing pattern of publications/interest, and second is related to health crisis and economical impact generated by coronavirus. url: https://doi.org/10.1101/2020.08.15.20175810 doi: 10.1101/2020.08.15.20175810 id: cord-264203-7dnz9yaa author: Coldefy, Magali title: The geography of institutional psychiatric care in France 1800–2000: Historical analysis of the spatial diffusion of specialised facilities for institutional care of mental illness date: 2010-10-10 words: 11259.0 sentences: 493.0 pages: flesch: 43.0 cache: ./cache/cord-264203-7dnz9yaa.txt txt: ./txt/cord-264203-7dnz9yaa.txt summary: It seems that trends depend on national context since a rather contrasting American study (Hunter, Shannon, & Sambrook, 1986) , reports the emergence and diffusion of public ''lunatic asylums'' in the United States during the 19th century, demonstrating how over time the establishment of these facilities spread from the north-east to the west of the country. To investigate spatial diffusion of psychiatric hospitals in France from the 19th century to the present day, the initial task involved building an original historical database of psychiatric hospitals, their location and date of establishment, indicating the points at which, in different parts of France, asylum facilities were first adopted as innovative care institutions for the mentally ill. For example, a psychiatric ward in a general hospital, could have constituted an ''acceptable'' way of caring for people with mental health problems in a département and such provision may have resulted in a delay in the establishment of a dedicated asylum facility in that area, or progressive independent institutions may have played a role in the dissemination of alienist ideas in psychiatry. abstract: As in other European countries, specialised psychiatric hospitals were established throughout France during the 19th Century. The construction of these hospitals can be considered as the concrete expression of a therapeutic innovation which recognized insanity as an illness that could be treated in such specialised institutions. The spatial diffusion of these innovative institutions through 19th and 20th century France is analysed and we explore how far this can be understood through theories of diffusion of innovations including geographical models of hierarchical and expansion diffusion (or whether other conceptual models are more appropriate). The research reported here particularly focuses on the period 1800–1961. It involved the construction of an original historical database of both psychiatric hospitals and information on the cities where these institutions were located. This was used to examine and interpret the different phases of development of psychiatric institutions and the parts of the country and types of geographical setting where they were concentrated. A multiple correspondence analysis was then performed to examine the connections between different aspects of the diffusion process. The study shows the limitations of classical models of spatial diffusion, which are found to be consistent with some, but not all aspects of the development of psychiatric institutions in France. An alternative political ecology approach seems more appropriate to conceptualise the various processes involved; national policies, social representations, medicalisation of care of mental illness, and urban and economic growth all seem to be associated with the emergence of a variable and complex pattern. This paper also opens a large field of research. Compared with other western countries, the geography of French psychiatric care is relatively under-researched, although there has been a strong spatial dimension to mental health policy in the country. This analysis provides a context for studies of more contemporary processes of French deinstitutionalisation, which is strongly structured by the past heritage of these large asylum facilities. url: https://www.ncbi.nlm.nih.gov/pubmed/21055855/ doi: 10.1016/j.socscimed.2010.09.028 id: cord-355549-6xnjj5h5 author: Cécile, Couchoud title: Low incidence of SARS-CoV-2, risk factors of mortality and the course of illness in the French national cohort of dialysis patients. date: 2020-08-25 words: 4006.0 sentences: 211.0 pages: flesch: 50.0 cache: ./cache/cord-355549-6xnjj5h5.txt txt: ./txt/cord-355549-6xnjj5h5.txt summary: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. The aim of this first report from the French REIN registry is to describe the population of infected dialysis patients and their course of illness, estimate the incidence and lethality of COVID-19 disease and identify the risk factors associated with the probability of death. This can also be associated with the implementation of all the necessary preventive actions prone by the SFNDT, including 1/wearing a mask during transport and for the entire period of care, 2/systematic tracking of patients and screening at the entrance to dialysis units based on fever and symptoms or contact with an infected person and 3/restricting areas for COVID-19 cases (18),. abstract: The aim of this study was to estimate the incidence of COVID-19 disease in the French national population of dialysis patients, their course of illness and to identify the risk factors associated with mortality. Our study included all patients on dialysis recorded in the French REIN Registry in April 2020. Clinical characteristics at last follow-up and the evolution of COVID-19 illness severity over time were recorded for diagnosed cases (either suspicious clinical symptoms, characteristic signs on the chest scan or a positive reverse transcription polymerase chain reaction) for SARS-CoV-2. A total of 1,621 infected patients were reported on the REIN registry from March 16th, 2020 to May 4th, 2020. Of these, 344 died. The prevalence of COVID-19 patients varied from less than 1% to 10% between regions. The probability of being a case was higher in males, patients with diabetes, those in need of assistance for transfer or treated at a self-care unit. Dialysis at home was associated with a lower probability of being infected as was being a smoker, a former smoker, having an active malignancy, or peripheral vascular disease. Mortality in diagnosed cases (21%) was associated with the same causes as in the general population. Higher age, hypoalbuminemia and the presence of an ischemic heart disease were statistically independently associated with a higher risk of death. Being treated at a selfcare unit was associated with a lower risk. Thus, our study showed a relatively low frequency of COVID-19 among dialysis patients contrary to what might have been assumed. url: https://www.sciencedirect.com/science/article/pii/S0085253820309595?v=s5 doi: 10.1016/j.kint.2020.07.042 id: cord-000425-isw6jeir author: Flori, Laurence title: Immunity Traits in Pigs: Substantial Genetic Variation and Limited Covariation date: 2011-07-29 words: 7831.0 sentences: 388.0 pages: flesch: 46.0 cache: ./cache/cord-000425-isw6jeir.txt txt: ./txt/cord-000425-isw6jeir.txt summary: A study on Yorkshire pigs selected for eight generations for high and low adaptive IR (HIR and LIR, respectively) on an index combining four standardized measures of specific antibodies and cellmediated IR, after stimulation with specific antigens (bacillus Calmette-Guérin and hen egg white lysozyme), has revealed that HIR and LIR animals differ in response to immunization and infection [2, 11, 12, 13, 14] . Finally, several significant QTLs for total leukocyte count ( [20, 21] ; Animal-QTLdb, http://www.animalgenome.org/cgi-bin/QTLdb/index), mitogen-induced proliferation [20] , antibody response [20, 22] , cytokine production (IL10 and IFNc) [23] , complement activity [22] , and acute phase protein serum concentration [22] have been detected and mapped to different pig chromosomes. In this report, we present the results of a global genetic study, combining principal component analysis (PCA), and genetic parameter estimation applied to a large number of innate and adaptive ITs in a pig population vaccinated against Mycoplasma hyopneumoniae (M. abstract: BACKGROUND: Increasing robustness via improvement of resistance to pathogens is a major selection objective in livestock breeding. As resistance traits are difficult or impossible to measure directly, potential indirect criteria are measures of immune traits (ITs). Our underlying hypothesis is that levels of ITs with no focus on specific pathogens define an individual's immunocompetence and thus predict response to pathogens in general. Since variation in ITs depends on genetic, environmental and probably epigenetic factors, our aim was to estimate the relative importance of genetics. In this report, we present a large genetic survey of innate and adaptive ITs in pig families bred in the same environment. METHODOLOGY/PRINCIPAL FINDINGS: Fifty four ITs were studied on 443 Large White pigs vaccinated against Mycoplasma hyopneumoniae and analyzed by combining a principal component analysis (PCA) and genetic parameter estimation. ITs include specific and non specific antibodies, seric inflammatory proteins, cell subsets by hemogram and flow cytometry, ex vivo production of cytokines (IFNα, TNFα, IL6, IL8, IL12, IFNγ, IL2, IL4, IL10), phagocytosis and lymphocyte proliferation. While six ITs had heritabilities that were weak or not significantly different from zero, 18 and 30 ITs had moderate (0.1