id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005432-mqyvpepo	Ma, Z	Redirecting adenovirus to pulmonary endothelium by cationic liposomes	2002-02-22		.txt	text/plain	3980	235	50	A recent study has shown that the use of a bispecific antibody to endothelial cells and Ad vectors efficiently redirects Ad vectors to pulmonary endothelium and improves gene expression in the lung. 10 To test whether preinjection of cationic liposomes can also enhance Ad vector-mediated pulmonary gene transfer, groups of six mice received tail vein injection of various amounts of DOTAP:cholesterol liposomes followed by injection of AdCMVLuc. Gene expression was assayed 3 days following the injection. 12 To Gene Therapy examine whether lipid complexation can similarly enhance pulmonary gene transfer by Ad vectors via the vascular route, AdCMVLuc was mixed with various amounts of DOTAP:cholesterol liposomes and gene expression was assayed 3 days following the injection of the complexed AdCMVLuc. In contrast to sequential injection, premixing of cationic liposomes with AdCM-VLuc resulted in a decreased gene expression in all major organs examined ( Figure 2 ).	./cache/cord-005432-mqyvpepo.txt	./txt/cord-005432-mqyvpepo.txt