id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-265581-pbv8mjfc	Tong, Yaojun	An aurora of natural products-based drug discovery is coming	2020-06-06		.txt	text/plain	3077	155	46	With recent scientific advances combining metabolic sciences and technology, multi-omics, big data, combinatorial biosynthesis, synthetic biology, genome editing technology (such as CRISPR), artificial intelligence (AI), and 3D printing, the "high-hanging fruit" is becoming more and more accessible with reduced costs. The incredible rate of development in genome sequencing, modern metabolic engineering, synthetic biology, advanced genome editing, big data, artificial intelligence (AI), and 3D printing together with the growing microbial strain collections enable us to access the previously inaccessible natural products. It starts with genome mining (the analysis of high quality whole genome information), which requires bioinformatics, big data, and even AI; to pathway cloning (refactoring), expression and fermentation, which needs design-buildtest-learn (DBTL) cycle-based metabolic engineering; to the target natural product identification, which requires modern chemical analysis; and to later compound modification and clinical studies, which needs biochemistry and cell biology.	./cache/cord-265581-pbv8mjfc.txt	./txt/cord-265581-pbv8mjfc.txt