id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-264526-bxpzo2xu	Aydin, Malik	House Dust Mite Exposure Causes Increased Susceptibility of Nasal Epithelial Cells to Adenovirus Infection	2020-10-11		.txt	text/plain	5032	283	47	This ex vivo pilot study shows the impact of AdV infection and HDM exposition in a primary cell culture model for asthma. Although various studies have investigated the molecular roles of some respiratory viruses in allergic pathways [14, 15] , the relationship between AdV infection and HDM sensitization in asthma exacerbation has not been sufficiently analyzed. To analyze AdV infection in the context of HDM sensitization, we utilized primary nasal NAEPCs derived from our pediatric exacerbation study cohort in submerged 2D and organotypic 3D cell culture models. Especially on day 3 after HDM exposure, we observed an enhanced AdV mediated luciferase activity in HDM-provoked NAEPCs from asthmatics, compared to NAEPCs derived from healthy cells ( Figure 6 ). Here, we characterized the effects of HDM exposition on AdV infection in an ex vivo cell culture models of NAEPCs of exacerbated pediatric asthmatics and healthy controls from our pediatric exacerbation study.	./cache/cord-264526-bxpzo2xu.txt	./txt/cord-264526-bxpzo2xu.txt