id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001123-n2e4s7bu	Lin, Yue-Zhi	The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells	2013-11-22		.txt	text/plain	5827	282	51	title: The Soluble Form of the EIAV Receptor Encoded by an Alternative Splicing Variant Inhibits EIAV Infection of Target Cells In addition to the previously described membrane-associated form of ELR1, two other major alternative splicing variant mRNAs were identified in equine monocyte-derived macrophages (eMDMs). This result strongly indicated that overexpressed recombinant sELR1 was able to inhibit EIAV infection in vitro, probably by competing with the membrane-associated receptor for the binding of virions on target cells. Thus, the soluble form of ELR1, tagged with HA, was overexpressed in FED cells, a major target of EIAV in vitro, by transfection with the sELR1 expression vector pcDNA3.1-ELR1-IN. The regulated expression levels of both the soluble and membrane-associated forms of ELR1 by EIAV reveal the possible role of sELR1 in the interaction between virus and host.	./cache/cord-001123-n2e4s7bu.txt	./txt/cord-001123-n2e4s7bu.txt