id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001365-6u80p5sj	Weger-Lucarelli, James	A Novel MVA Vectored Chikungunya Virus Vaccine Elicits Protective Immunity in Mice	2014-07-24		.txt	text/plain	8471	426	51	Despite the presence of high levels of neutralizing antibodies elicited by most of the VACV vectored VEEV vaccine candidates, they were ineffective in providing protection against airborne infection, suggesting they were unable to elicit a sufficient T cell mediated immune response, which has been shown to be critical for protection against lethal VEEV encephalitis [34, 35] . Most importantly, depletion of CD4 + T cells in vaccinated mice resulted in loss of protection, with 100% succumbing to infection upon challenge with wild-type CHIKV, indicating an indispensable role of MVA-CHIK immune CD4+ T cells in protection. Expression of E2 was observed in the supernatant of CHIKV infected cells, but there Prior to boost (where applicable) and challenge, mice were bled and serum was monitored for both total Ig(G+M) and neutralizing activity by TCID 50 was no detection of E2 expression in MVA-CHIK, suggesting that the protein was not being secreted.	./cache/cord-001365-6u80p5sj.txt	./txt/cord-001365-6u80p5sj.txt