id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-018572-e2qq4ngq	Jackson, Catherine L.	Arf Proteins and Their Regulators: At the Interface Between Membrane Lipids and the Protein Trafficking Machinery	2014-05-22		.txt	text/plain	10461	515	48	This feature is conserved in modern organisms, for example, in humans, which have only 5 Arf proteins, yet at least 15 GEFs and 31 GAPs. Perhaps a clue as to the Arf4 TGN VxPx targeting motif AP adaptor protein, BAR Bin/Amphiphysin/Rvs, CC coiled-coil, COP coatomer protein, ER endoplasmic reticulum, ERGIC ER-Golgi intermediate compartment, GAT GGA (Golgi-localized, γ-adaptin homologous, ADP-ribosylation factor-binding protein) and TOM1 homologous, GRAB GRIP (golgin-97/RabBP2α/Imh1p/p230)-related Arf binding, PM plasma membrane, TGN trans-Golgi network; ND, not determined nature of the primordial Arf protein comes from the protozoan parasite Trypanosoma brucei, which expresses a single Arf protein that has characteristics of both Class I and Class III mammalian Arfs. How a single Arf protein can recruit multiple coats to different membrane sites in cells is still not fully understood, but one important contribution to specificity comes from the Arf GEFs. In both mammalian and yeast cells, GBF1 and Gea1/2, respectively, interact directly with COPI (Deng et al.	./cache/cord-018572-e2qq4ngq.txt	./txt/cord-018572-e2qq4ngq.txt