id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-302695-vyo3w2a4	Albertini, Laetitia	Observational study on off-label use of tocilizumab in patients with severe COVID-19	2020-09-10		.txt	text/plain	5025	294	62	This is a single-centre observational cohort study of patients infected with COVID-19 and treated with TCZ between 6 April and 21 April 2020 at our general hospital. The criteria for receiving TCZ were: ► Hospitalised patients with a positive diagnosis of COVID-19 (by real-time PCR on nasopharyngeal swabs) ► Extensive bilateral lesions in the lungs ► Severe respiratory insufficiency needing oxygen supplementation (≥5 L) ► Clinical aggravation ► Increased CRP level ► No major contraindications to the drug. On day 14, in the TCZ group two patients required invasive ventilation compared with six in the control group (95% CI −0.4 to 0.05) (p=0.12) (figure 1). Indeed, on day 14 of follow-up, two patients in the TCZ group required invasive ventilation compared with six in the control group. The need for oxygen was reduced in the TCZ group despite the fact that this group had more severe clinical and radiological impairment of COVID-19 at the beginning of the study.	./cache/cord-302695-vyo3w2a4.txt	./txt/cord-302695-vyo3w2a4.txt