Carrel name: keyword-group-cord Creating study carrel named keyword-group-cord Initializing database parallel: Warning: Only enough available processes to run 59 jobs in parallel. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf parallel: Warning: or /proc/sys/kernel/pid_max may help. file: cache/cord-004091-gex0zvoa.json key: cord-004091-gex0zvoa authors: Abdulkareem, Shaheen A.; Augustijn, Ellen-Wien; Filatova, Tatiana; Musial, Katarzyna; Mustafa, Yaseen T. title: Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date: 2020-01-06 journal: PLoS One DOI: 10.1371/journal.pone.0226483 sha: doc_id: 4091 cord_uid: gex0zvoa file: cache/cord-001236-cgiok0ce.json key: cord-001236-cgiok0ce authors: Binjawadagi, Basavaraj; Dwivedi, Varun; Manickam, Cordelia; Ouyang, Kang; Torrelles, Jordi B; Renukaradhya, Gourapura J title: An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination date: 2014-03-24 journal: Int J Nanomedicine DOI: 10.2147/ijn.s59924 sha: doc_id: 1236 cord_uid: cgiok0ce file: cache/cord-003825-tkqxb1ql.json key: cord-003825-tkqxb1ql authors: Toman, Miroslav; Celer, Vladimir; Kavanová, Lenka; Levá, Lenka; Frolichova, Jitka; Ondráčková, Petra; Kudláčková, Hana; Nechvátalová, Kateřina; Salat, Jiri; Faldyna, Martin title: Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus date: 2019-08-06 journal: Front Immunol DOI: 10.3389/fimmu.2019.01689 sha: doc_id: 3825 cord_uid: tkqxb1ql file: cache/cord-004373-nmnssoeb.json key: cord-004373-nmnssoeb authors: Wall, Jonathan T.; Kaiser, Bonnie N.; Friis-Healy, Elsa A.; Ayuku, David; Puffer, Eve S. title: What about lay counselors’ experiences of task-shifting mental health interventions? Example from a family-based intervention in Kenya date: 2020-02-20 journal: Int J Ment Health Syst DOI: 10.1186/s13033-020-00343-0 sha: doc_id: 4373 cord_uid: nmnssoeb file: cache/cord-003673-u7711eb4.json key: cord-003673-u7711eb4 authors: Xiong, Xiao-Li; Ding, Yan; Chen, Zhi-Lin; Wang, Yao; Liu, Pan; Qin, Huan; Zhou, Li-Shan; Zhang, Ling-Ling; Huang, Juan; Zhao, Lei title: Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile date: 2019-05-22 journal: Front Pharmacol DOI: 10.3389/fphar.2019.00522 sha: doc_id: 3673 cord_uid: u7711eb4 file: cache/cord-003913-jr9hj0bs.json key: cord-003913-jr9hj0bs authors: Park, Hyeong-Jun; Ko, Hae Li; Won, Dong-Hoon; Hwang, Da-Bin; Shin, Yoo-Sub; Kwak, Hye-Won; Kim, Hye-Jung; Yun, Jun-Won; Nam, Jae-Hwan title: Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant date: 2019-09-07 journal: Pharmaceutics DOI: 10.3390/pharmaceutics11090464 sha: doc_id: 3913 cord_uid: jr9hj0bs file: cache/cord-004342-9uok77wb.json key: cord-004342-9uok77wb authors: Lin, Chun-Yu; Lu, Cheng-Hui; Lee, Hsiu-An; See, Lai-Chu; Wu, Meng-Yu; Han, Yi; Tseng, Chi-Nan; Su, I-Li; Li, Han-Yan; Tsai, Feng-Chun title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 journal: Sci Rep DOI: 10.1038/s41598-020-59657-1 sha: doc_id: 4342 cord_uid: 9uok77wb file: cache/cord-005379-5x4deimg.json key: cord-005379-5x4deimg authors: Xu, Jing-Xiu; Zhang, Cong; Cao, Chang-Yu; Zhu, Shi-Yong; Li, Hui; Sun, Yan-Chun; Li, Jin-Long title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels date: 2015-08-19 journal: Biol Trace Elem Res DOI: 10.1007/s12011-015-0470-9 sha: doc_id: 5379 cord_uid: 5x4deimg file: cache/cord-003024-17f1evh3.json key: cord-003024-17f1evh3 authors: Nunes, Márcio Roberto Teixeira; de Souza, William Marciel; Acrani, Gustavo Olszanski; Cardoso, Jedson Ferreira; da Silva, Sandro Patroca; Badra, Soraya Jabur; Figueiredo, Luiz Tadeu Moraes; Vasconcelos, Pedro Fernando da Costa title: Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas date: 2018-05-24 journal: PLoS One DOI: 10.1371/journal.pone.0197294 sha: doc_id: 3024 cord_uid: 17f1evh3 file: cache/cord-006578-wv3wc0ct.json key: cord-006578-wv3wc0ct authors: Stevens, D. L. title: Invasive streptococcal infections date: 2001 journal: J Infect Chemother DOI: 10.1007/s101560100012 sha: doc_id: 6578 cord_uid: wv3wc0ct file: cache/cord-001809-azb7nie3.json key: cord-001809-azb7nie3 authors: Qvarnstrom, Yvonne; Nerad, Thomas A.; Visvesvara, Govinda S. title: Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis date: 2013-07-24 journal: J Eukaryot Microbiol DOI: 10.1111/jeu.12069 sha: doc_id: 1809 cord_uid: azb7nie3 file: cache/cord-002774-tpqsjjet.json key: cord-002774-tpqsjjet authors: nan title: Section II: Poster Sessions date: 2017-12-01 journal: J Urban Health DOI: 10.1093/jurban/jti137 sha: doc_id: 2774 cord_uid: tpqsjjet file: cache/cord-009797-8mdie73v.json key: cord-009797-8mdie73v authors: Valle, Denis; Albuquerque, Pedro; Zhao, Qing; Barberan, Albert; Fletcher, Robert J. title: Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change date: 2018-08-26 journal: Glob Chang Biol DOI: 10.1111/gcb.14412 sha: doc_id: 9797 cord_uid: 8mdie73v file: cache/cord-007580-qwh8ei60.json key: cord-007580-qwh8ei60 authors: Knopf, Harry L.S.; Hierholzer, John C. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 journal: Am J Ophthalmol DOI: 10.1016/0002-9394(75)90398-0 sha: doc_id: 7580 cord_uid: qwh8ei60 file: cache/cord-010390-lc22hp3o.json key: cord-010390-lc22hp3o authors: Nenna, Raffaella; Frassanito, Antonella; Petrarca, Laura; Di Mattia, Greta; Midulla, Fabio title: Age Limit in Bronchiolitis Diagnosis: 6 or 12 Months? date: 2020-04-20 journal: Front Pediatr DOI: 10.3389/fped.2020.00144 sha: doc_id: 10390 cord_uid: lc22hp3o file: cache/cord-010501-kd95xvsg.json key: cord-010501-kd95xvsg authors: Zenetos, Argyro; Papathanassiou, Evangelos; Aartsen, Jacobus J. Van title: Analysis of Benthic Communities in the Cyclades Plateau (Aegean Sea) Using Ecological and Paleoecological Data Sets date: 2008-06-28 journal: Mar Ecol (Berl) DOI: 10.1111/j.1439-0485.1991.tb00247.x sha: doc_id: 10501 cord_uid: kd95xvsg file: cache/cord-006987-1hf8vyhz.json key: cord-006987-1hf8vyhz authors: Abass, Ahmed O; Kamel, Nancy N; Khalifa, Walaa H; Gouda, G F; El-Manylawi, M A F; Mehaisen, Gamal M K; Mashaly, Magdi M title: Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults date: 2017-10-05 journal: Poult Sci DOI: 10.3382/ps/pex248 sha: doc_id: 6987 cord_uid: 1hf8vyhz file: cache/cord-013263-xw611i8k.json key: cord-013263-xw611i8k authors: Dederichs, Melina; Weber, Jeannette; Muth, Thomas; Angerer, Peter; Loerbroks, Adrian title: Students’ perspectives on interventions to reduce stress in medical school: A qualitative study date: 2020-10-15 journal: PLoS One DOI: 10.1371/journal.pone.0240587 sha: doc_id: 13263 cord_uid: xw611i8k file: cache/cord-006984-x1r99rlm.json key: cord-006984-x1r99rlm authors: Yokhana, J. S.; Parkinson, G.; Frankel, T. L. title: Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry date: 2015-11-14 journal: Poult Sci DOI: 10.3382/ps/pev336 sha: doc_id: 6984 cord_uid: x1r99rlm file: cache/cord-009962-k3opc553.json key: cord-009962-k3opc553 authors: Stjernquist‐Desatnik, Anna; Orrling, Arne title: Pharyngotonsillitis date: 2008-12-17 journal: Periodontol 2000 DOI: 10.1111/j.1600-0757.2008.00282.x sha: doc_id: 9962 cord_uid: k3opc553 file: cache/cord-010530-w8ir0e07.json key: cord-010530-w8ir0e07 authors: MOURA, HERCULES; WALLACE, SARA; VISVESVARA, GOVINDA S. title: Acanthamoeba healyi N. Sp. and the Isoenzyme and Immunoblot Profiles of Acanthamoeba spp., Groups 1 and 3 date: 2007-05-01 journal: J Protozool DOI: 10.1111/j.1550-7408.1992.tb04853.x sha: doc_id: 10530 cord_uid: w8ir0e07 file: cache/cord-012537-49v45di6.json key: cord-012537-49v45di6 authors: El-Ghandour, Mamdouh; Hammad, Bahaa; Ghanem, Mohamed; Antonios, Manal A. M. title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial date: 2020-08-28 journal: Paediatr Drugs DOI: 10.1007/s40272-020-00412-4 sha: doc_id: 12537 cord_uid: 49v45di6 file: cache/cord-006864-t5qsjyfi.json key: cord-006864-t5qsjyfi authors: Norris, S.; Collins, C.; Hegarty, J.; O’Farrelly, C.; Carton, J.; Madrigal, L.; O’Donoghue, D. P.; O’Farrelly, C.; Holloway, H.; Fielding, J. F.; Mullins, W.; Hone, S. W.; Donnelly, M.; Powell, F.; Blayney, A. W.; Cahill, E. A.; Daly, S. F.; Turner, M. J.; Sullivan, P. A.; McLoughlin, M.; Skelly, M. M.; Mulcahy, H. E.; Connell, T.; O’Donoghue, D. P.; Duggan, C.; Duffy, M. J.; Troy, A.; Sheahan, K.; Whelan, A.; Herra, C. M.; Keane, C. T.; Johnson, H.; Lee, B.; Doherty, E.; McDonnell, T.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Hassett, H. M.; Boyce, A.; Greig, V.; O’Herlihy, C.; Smyth, P. P. A.; Roche, E. F.; McCormack, I.; Tempany, E.; Cullen, M. J.; Smith, D. F.; Smyth, P. P. A.; McBrinn, Y.; Murray, B.; Freaney, R.; Keating, D.; McKenna, M. J.; O’Hare, J. A.; Alam, H.; Raza, Q.; Geoghegan, M.; Killalea, S.; Hall, M.; Feely, J.; Kyne, L.; O’Hara, B.; Cullen, M.; Rea, I. M.; Donnelly, J. P.; Stout, R. W.; Lacey, P.; Donnelly, M. J.; McGrath, J.; Hennessy, T. P.; Timon, C. V. I.; Hyde, D.; Xia, H. X.; Keane, C. T.; Buckley, M.; O’Morain, C.; Buckley, M.; Keating, S.; Xia, H.; Hyde, D.; O’Morain, C.; McGrath, J. P.; Stuart, R. C.; Lawlor, P.; Byrne, P. J.; Walsh, T. N.; Hennessy, T. P. J.; Skelly, M. M.; Mulcahy, H. E.; Connell, T.; O’Donoghue, D. P.; Duggan, C.; Duffy, M.; Troy, A.; Sheahan, K.; Norris, S.; Tubridy, M.; Redmond, J.; Hegarty, J.; Holloway, H.; Fielding, J. F.; Mullins, W.; Monahan, K.; Murphy, R. P.; Headon, D. R.; O’Gorman, T.; O’Reilly, F. M.; Darby, C.; Fielding, J. F.; Murphy, G. M.; Murphy, A.; Codd, M.; Powell, F.; Dervan, P.; Lawlor, D.; Loughlin, S. O.; Flanagan, N.; Watson, R.; Barnes, L.; Flanagan, N.; Watson, R.; Kilgallen, C.; Sweeney, E.; Mynes, A.; Mooney, D.; Donoghue, I.; Browne, O.; Kirrane, J. A.; Murphy, G. M.; McKenna, D.; Young, M.; McKenna, D.; Young, M.; O’Toole, E.; Young, M.; O’Briain, S.; Srinivasan, U.; Feighery, C.; Leonard, N.; Jones, E.; O’Farrelly, C.; Moloney, M. A.; O’Farrelly, C.; Weir, D. G.; Lawler, M.; O’Neill, A.; Gowing, H.; Pamphilon, D.; McCann, S. R.; O’Toole, G.; Orren, A.; Seifer, C. M.; Crowley, D. C.; Sheehan, G. J.; Deignan, T.; Kelly, J.; O’Farrelly, C.; Tormey, V. J.; Faul, J.; Leonard, C.; Burke, C. M.; Poulter, L. W.; Collins, C.; Lynch, S.; Madrigal, L.; Norris, S.; McEntee, G.; Traynor, O.; Hegarty, J.; O’Farrelly, C.; Barry, E.; Collins, C.; Costello, P.; Keavney, A.; O’Donoghue, D. P.; O’Farrelly, C.; Willoughby, R.; Feighery, C.; O’Donnell, C.; Cahill, M.; Earley, A.; Eustace, P.; Osborne, R.; Cahill, M.; Saidlear, C.; Holmes, B.; Early, A.; Eustace, P.; Moran, A. P.; Neisser, A.; Polt, R. J.; Bernheimer, H.; Kainz, M.; Schwerer, B.; Gallagher, L.; Cahill, M.; Saidlear, C.; Early, A.; Firth, R.; Eustace, P.; Kennedy, N.; McGilloway, E.; Redmond, J.; McGilloway, E.; Kennedy, N.; Tubridy, N.; Shields, K.; Cullen, W. K.; Rowan, M. J.; Moore, A. R.; Rowan, M.; Feely, J.; Coakley, D.; Lawlor, B.; Swanwick, G.; Al-Naeemi, R.; Redmond, J.; Murphy, R.; Feely, J.; Codd, N. M.; Goggins, M.; Kennedy, N. P.; Mallon, B. L.; Kennedy, N. P.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Mulcahy, H.; Skelly, M.; Donoghue, D. O.; McCarthy, D.; Saunders, A.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Veale, D. J.; Belch, J. J. F.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Veale, D. J.; Belch, J. J. F.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Costello, P.; Breathnach, D.; Murphy, E.; Mulherin, D.; FitzGerald, O.; Bresnihan, B.; Breathnach, D.; Costello, P.; Mulherin, D.; Bresnihan, B.; FitzGerald, O.; Breathnach, D.; Mulherin, D.; Costello, P.; Bresnihan, B.; FitzGerald, O.; Kernohan, G.; Gibson, K.; Wilson, A. G.; Duff, G. W.; de Vries, N.; van de Putte, L. B. A.; Donoghue, J.; O’Kelly, F.; Johnson, Z.; Maher, T.; Kyne, L.; Moran, A.; Keane, C.; O’Neill, D.; Horgan, N.; Barragry, J. M.; O’Neill, D.; O’Herlihy, C.; Campbell, D. M.; Behan, M.; O’Connell, P. R.; Donnelly, V. S.; Crowley, D.; Geary, M.; Boylan, P.; Geary, M.; Fanagan, M.; Boylan, P.; Hickey, K.; Teoh, T.; Doyle, M.; Harrison, R.; Hickey, K.; Lyons, D.; Shenouda, Y.; Coughlan, M.; McKenna, P.; Hickey, K.; Shenouda, Y.; Lyons, D.; McKenna, P.; Coughlan, M.; Lenehan, P.; Foley, M.; Kelehan, P.; Ravichandran, P.; Kelly, M.; Conroy, A.; Fitzpatrick, C.; Egan, D.; Regan, C. L.; McAdam, B. V.; McParland, P.; Boylan, P.; FitzGerald, G. A.; Fitzgerald, D. J.; Sharma, S. C.; Foran, K.; Barry-Kinsella, C.; Harrison, R. F.; Gillespie, F. J.; O’Mahony, P.; Boyle, M.; White, M. J.; Donohoe, F.; Birrane, Y.; Naughton, M.; Tempany, E.; Fitzsimons, R. B.; Piracha, M.; McConkey, S.; Griffin, E.; Hayes, E.; Clarke, T.; Parfrey, N.; Butler, K.; Fitzpatrick, C.; Malone, A. J.; Kearney, P. J.; Duggan, P. F.; Lane, A.; Keville, R.; Turner, M.; Barry, S.; Sloan, D.; Gallagher, S.; Darby, M.; Galligan, P.; Stack, J.; Walsh, N.; O’Sullivan, M.; Fitzgerald, M.; O’Sullivan, M.; Meagher, D.; Sloan, D.; Browne, S.; Meagher, D.; Larkin, C.; Lane, A.; Casey, P.; O’Callaghan, E.; Walsh, N.; Rooney, S.; Walsh, E.; Morris, M.; Lane, A.; Burke, T.; Larkin, C.; O’Callaghan, E.; Browne, S.; Roe, M.; Lane, A.; Larkin, C.; O’Callaghan, E.; Maher, C.; Wrigley, M.; Gill, M.; Burgess, M.; Corcoran, E.; Walsh, D.; Gilmer, B.; Johnson, H.; Hayes, C. B.; Thornton, L.; Fogarty, J.; Lyons, R.; O’Connor, M.; Delaney, V.; Buckley, K.; Johnson, Z.; Johnson, Z.; Lillis, D.; Delany, V.; Hayes, C.; Dack, P.; Igoe, D.; Gilmer, B.; O’Neill, H. J.; Johnson, H.; Igoe, D.; Delaney, V.; Johnson, Z.; Kelly, P.; McKeown, D.; Clancy, L.; Varghese, G.; Hennessy, S.; Codd, M.; Gilmartin, J. J.; Birthistle, K.; Carrington, D.; Maguire, H.; Atkinson, P.; Foley-Nolan, C.; Lynch, M.; Cryan, B.; Whyte, D.; Cryan, B.; Conlon, C.; Foley-Nolan, C.; Johnson, Z.; Hayes, C.; Delany, V.; Kucinskas, V.; Usinskiene, U.; Sakalyte, I.; Johnson, Z.; Hayes, C.; Delaney, V.; Dack, P.; Gill, M.; Dawson, E.; Molloy, K.; Goulden, N.; Lawler, M.; McCann, S. R.; Doyle, J.; Lawlor, E.; Lawler, M.; Harrington, M. G.; El-Nageh, N.; Nolan, M. -L.; El-Nageh, N.; Nolan, M. -L.; Harrington, M. G.; Lawlor, E.; O’Riordan, J.; McCann, S. R.; Judge, G.; Crotty, G.; Finch, T.; Borton, M.; Barnes, T.; Gilligan, O.; Lee, G.; Limmer, R.; Madden, M.; Whyte, D.; Cryan, B.; Bergin, C.; O’Leary, A.; Keating, S.; Mulcahy, F.; Wallis, F.; Glennon, M.; Cormican, M.; NiRiain, U.; Heiginbothom, M.; Gannon, F.; Smith, T.; O’Sullivan, C.; Hone, R.; Orren, A.; Caugant, D. A.; Fijen, C. A. P.; Van Schalkwyk, E. J.; Coetzee, G. J.; Lynch, M.; Cryan, B.; Riain, U. Ni; Cormican, M. G.; Park, L.; Flynn, J.; Glennon, M.; O’Connor, M.; Regazzoli, V.; O’Connor, M.; Hayes, M.; Nicholson, G.; Higgins, P.; NiRiain, U.; Flynn, N.; Corbett-Feeney, G.; Conway, D. J.; Sheahan, K.; O’Higgins, N. J.; Smyth, P. P. A.; Rajendiran, S.; Byrne, J.; Kilfeather, E.; Dingle, P.; Hunter, M.; Kelehan, P.; Al-Ghazal, S. K.; Stanley, P.; Palmer, J.; Hong, A.; Al-Ghazal, S. K.; Saxby, P.; Al-Ghazal, S. K.; Saxby, P.; McConkey, S.; Sheehan, D.; Regan, I.; O’Mullane, J.; Chaoimh, M. Ni; Leahy, M.; Heffron, J. J.; Lehane, M.; Keohane, C.; O’Leary, N.; Sheehan, M.; Renny-Walsh, E.; Whelton, M. J.; Doyle, C. T.; Webster, J.; Benjamin, N.; Lyons, D.; FitzGerald, S.; Chadha, J. S.; FitzGerald, M. G.; FitzGerald, G. R.; Hemeryck, L.; McGettigan, P.; Feely, J.; McGettigan, P.; Feely, J.; McGettigan, P.; Golden, J.; Feely, J.; Arthur, N.; Wen, S. Y.; Killalea, S.; Deegan, P.; McGettigan, P.; Feely, J.; Cooke, T.; Adebayo, G. I.; Feely, J.; Gaffney, P.; Sinnot, M.; O’Riordan, D.; Hayes, T.; O’Connor, C. M.; FitzGerald, M. X.; Costello, C.; Finlay, G.; Hayes, J.; O’Connor, C.; FitzGerald, M. X.; McMahon, K.; O’Farrelly, C.; O’Connor, C.; FitzGerald, M. X.; Donnelly, M. J.; Hone, S.; Robertson, J.; Coakley, R.; O’Neill, S.; Walsh, M.; McCarthy, J.; Lannon, D.; Wood, A. E.; Sharkey, R.; Mulloy, E.; Long, M.; Kilgallen, I.; O’Neill, S.; Faul, J.; Tormey, V.; Leonard, C.; Burke, C. M.; Poulter, L. W.; Horne, S.; Tormey, V. J.; Faul, J.; Leonard, C.; Burke, C. M.; Feeney, T.; Muiré, Ó. Ó; Gilmartin, J. J.; Griffin, M. J.; Hughes, D.; Knaggs, A.; Magee, D.; Donnelly, M.; McCrory, C.; March, B.; Hone, R.; Phelan, D.; White, M.; Fabry, J.; Lynch, M.; Buggy, D.; Cooney, C.; Hughes, D.; McCrory, C.; Aziz, E.; O’Herlihy, C.; Kelly, J.; O’Keefe, D.; McShane, A. J.; Boylan, J.; Tobin, E.; Smith, T.; Motherway, C.; Colreavy, F.; Denish, N.; Dwyer, R.; Bergin, A.; O’Brien, K.; MacSullivan, R.; Carson, K. D.; Blunnie, W. P.; Moriarty, D. C.; Carson, K. D.; Blunnie, W. P.; Moriarty, D. C.; Kinirons, B.; Lyons, B.; Cregg, N.; Casey, W.; Moore, K. P.; Colbert, S. A.; Ecoffey, C.; O’Gorman, D.; Fitzgerald, J.; Phelan, D.; Diamond, P.; Codd, M. B.; Sugrue, D. D.; Kellett, J.; Tighe, M.; McKenna, C. J.; Galvin, J.; McCann, H. A.; Sugrue, D. D.; McKenna, C. J.; Codd, M. B.; McCann, H. A.; Sugrue, D. D.; Scallon, A.; Buckley, M.; Fraser, A.; Norton, M.; Tomkin, G.; Graham, I.; Byrne, A.; Maher, M.; Moran, N.; Fitzgerald, D.; O’Callaghan, D.; Coyle, D.; Nugent, A. G.; McGurk, C.; Johnston, G. D.; McGurk, C.; Nugent, A.; Silke, B.; Nugent, A. G.; Johnston, G. D.; Murphy, N.; Jennings, L.; Pratico, D.; Doyle, C.; Fitzgerald, D.; Hennessy, T.; McCann, H.; Sugrue, D.; Hennessy, T.; Codd, M.; Donnelly, S.; Hennessy, A.; Hartigan, C.; McCann, H.; Sugrue, D.; Hennessy, T.; Codd, M.; Donnelly, S.; Hennessy, A.; Hartigan, C.; McCann, H.; Sugrue, D.; Hennessy, T.; MacDonald, D.; Blake, S.; McCann, H.; Sugrue, D.; Hennessy, T.; Sugrue, D.; McCann, H.; Hennessy, T.; McCann, H.; Sugrue, D.; Hennessy, T.; McDonald, D.; Blake, S.; Dominque, D.; Sugrue, D.; McMechan, S. R.; MacKenzie, G.; Allen, J.; Wright, G. T.; Dempsey, G. J.; Crawley, M.; Anderson, J.; Adgey, A. A. J.; Harbinson, M. T.; Campbell, N. P. S.; Wilson, C. M.; Ellis, P. K.; McIlrath, E. M.; Freaney, R.; McShane, A.; Keaveny, T. V.; McKenna, M. J.; Rabenstein, K.; Scheller, F.; Pfeiffer, D.; Urban, C.; Moser, I.; Jobst, G.; Manz, A.; Verpoorte, S.; Dempsey, F.; Diamond, D.; Smyth, M.; Rabenstein, K.; Dempsey, E.; McShane, A.; Keaveny, T. V.; McKenna, M. J.; Freaney, R.; Hamilton, V.; Dwyer, R.; Twomey, J.; Crowley, R.; Fenelon, L.; Walsh, F.; McCann, J.; McDonagh, P.; White, M.; McGovern, E.; Luke, D.; Phelan, D.; McCrory, C.; Crowley, K.; Lyons, B.; Mannion, D.; Wood, A. E.; Casey, W.; Murphy, D.; Clarkson, K.; Carton, E.; Higgins, P.; Leonard, I.; O’Toole, D.; Staunton, M.; Phelan, D.; Srinivasan, U.; Leonard, N.; Jones, E.; Moloney, M. A.; Weir, D. G.; O’Farrelly, C.; Feighery, C.; Griffin, M.; Owens, D.; Collins, P.; Johnson, A.; Tomkin, G. H.; Herity, N. A.; Allen, J. D.; Silke, B.; Adgey, A. A. J.; O’Reilly, F. M.; Darby, C.; O’Moore, R.; Fielding, J. F.; Murphy, G. M.; Crotty, G. M.; Judge, G.; McCann, S. R.; DeArce, M.; Nugent, A. G.; McGurk, C.; Johnston, G. D.; Nikookam, K.; Keenan, P.; Cregan, D.; Firth, R.; O’Meara, N.; Forman, S.; Cusack, D. A.; Farrell, B. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 journal: Ir J Med Sci DOI: 10.1007/bf02967283 sha: doc_id: 6864 cord_uid: t5qsjyfi file: cache/cord-011147-55whf8md.json key: cord-011147-55whf8md authors: Sun, Hengchang; Shang, Mei; Tang, Zeli; Jiang, Hongye; Dong, Huimin; Zhou, Xinyi; Lin, Zhipeng; Shi, Cunbin; Ren, Pengli; Zhao, Lu; Shi, Mengchen; Zhou, Lina; Pan, Houjun; Chang, Ouqin; Li, Xuerong; Huang, Yan; Yu, Xinbing title: Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection date: 2020-01-07 journal: Appl Microbiol Biotechnol DOI: 10.1007/s00253-019-10316-0 sha: doc_id: 11147 cord_uid: 55whf8md file: cache/cord-014868-kg96uvpi.json key: cord-014868-kg96uvpi authors: Vita, S.; Dalessandri, A.; Alfonzetti, T.; Britti, D.; Boari, A. title: Evaluation of Total Proteins and Serum Protein Fractions in Cats Naturally Infected by Leishmania infantum–A Preliminary Study date: 2006 journal: Vet Res Commun DOI: 10.1007/s11259-006-0073-1 sha: doc_id: 14868 cord_uid: kg96uvpi file: cache/cord-006391-esnsa4u5.json key: cord-006391-esnsa4u5 authors: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 journal: Langenbecks Arch Chir DOI: 10.1007/bf01279099 sha: doc_id: 6391 cord_uid: esnsa4u5 file: cache/cord-005777-6rvfsx4p.json key: cord-005777-6rvfsx4p authors: nan title: PS 0420-0716 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0823-8 sha: doc_id: 5777 cord_uid: 6rvfsx4p file: cache/cord-013444-5aei9kaz.json key: cord-013444-5aei9kaz authors: Ruzauskas, Modestas; Bartkiene, Elena; Stankevicius, Arunas; Bernatoniene, Jurga; Zadeike, Daiva; Lele, Vita; Starkute, Vytaute; Zavistanaviciute, Paulina; Grigas, Juozas; Zokaityte, Egle; Pautienius, Arnoldas; Juodeikiene, Grazina; Jakstas, Valdas title: The Influence of Essential Oils on Gut Microbial Profiles in Pigs date: 2020-09-24 journal: Animals (Basel) DOI: 10.3390/ani10101734 sha: doc_id: 13444 cord_uid: 5aei9kaz file: cache/cord-007367-e31zhty6.json key: cord-007367-e31zhty6 authors: Tassier, Troy; Polgreen, Philip; Segre, Alberto title: Network position and health care worker infections date: 2015-09-07 journal: J Econ Interact Coord DOI: 10.1007/s11403-015-0166-4 sha: doc_id: 7367 cord_uid: e31zhty6 file: cache/cord-009969-ln91qfg4.json key: cord-009969-ln91qfg4 authors: Bertolesi, Gabriel E.; Zhang, John Zhijia; McFarlane, Sarah title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl date: 2019-03-10 journal: Pigment Cell Melanoma Res DOI: 10.1111/pcmr.12776 sha: doc_id: 9969 cord_uid: ln91qfg4 file: cache/cord-010305-z5c7zgp7.json key: cord-010305-z5c7zgp7 authors: GARDEN, JENNI G.; MCALPINE, CLIVE A.; POSSINGHAM, HUGH P.; JONES, DARRYL N. title: Habitat structure is more important than vegetation composition for local‐level management of native terrestrial reptile and small mammal species living in urban remnants: A case study from Brisbane, Australia date: 2007-08-06 journal: Austral Ecol DOI: 10.1111/j.1442-9993.2007.01750.x sha: doc_id: 10305 cord_uid: z5c7zgp7 file: cache/cord-012518-ncrdwtdg.json key: cord-012518-ncrdwtdg authors: nan title: Abstractband DOG 2020 date: 2020-08-24 journal: Ophthalmologe DOI: 10.1007/s00347-020-01197-0 sha: doc_id: 12518 cord_uid: ncrdwtdg file: cache/cord-003532-lcgeingz.json key: cord-003532-lcgeingz authors: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 journal: Crit Care DOI: 10.1186/s13054-019-2358-0 sha: doc_id: 3532 cord_uid: lcgeingz file: cache/cord-005646-xhx9pzhj.json key: cord-005646-xhx9pzhj authors: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 journal: Intensive Care Med DOI: 10.1007/bf02316512 sha: doc_id: 5646 cord_uid: xhx9pzhj file: cache/cord-014670-e31g8lns.json key: cord-014670-e31g8lns authors: nan title: Poster Sessions 313-503 date: 2004-10-05 journal: Intensive Care Med DOI: 10.1007/s00134-004-2406-2 sha: doc_id: 14670 cord_uid: e31g8lns file: cache/cord-005816-i54q5gsu.json key: cord-005816-i54q5gsu authors: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-009-8001-z sha: doc_id: 5816 cord_uid: i54q5gsu file: cache/cord-014538-6a2pviol.json key: cord-014538-6a2pviol authors: Kamilia, Chtara; Regaieg, Kais; Baccouch, Najeh; Chelly, Hedi; Bahloul, Mabrouk; Bouaziz, Mounir; Jendoubi, Ali; Abbes, Ahmed; Belhaouane, Houda; Nasri, Oussama; Jenzri, Layla; Ghedira, Salma; Houissa, Mohamed; Belkadi, Kamal; Harti, Youness; Nsiri, Afak; Khaleq, Khalid; Hamoudi, Driss; Harrar, Rachid; Thieffry, Camille; Wallet, Frédéric; Parmentier-Decrucq, Erika; Favory, Raphaël; Mathieu, Daniel; Poissy, Julien; Lafon, Thomas; Vignon, Philippe; Begot, Emmanuelle; Appert, Alexandra; Hadj, Mathilde; Claverie, Paul; Matt, Morgan; Barraud, Olivier; François, Bruno; Jamoussi, Amira; Jazia, Amira Ben; Marhbène, Takoua; Lakhdhar, Dhouha; Khelil, Jalila Ben; Besbes, Mohamed; Goutay, Julien; Blazejewski, Caroline; Joly-Durand, Isabelle; Pirlet, Isabelle; Weillaert, Marie Pierre; Beague, Sebastien; Aziz, Soufi; Hafiane, Reda; Hattabi, Khalid; Bouhouri, Mohamed Aziz; Hammoudi, Driss; Fadil, Abdelaziz; Harrar, Rachid Al; Zerouali, Khalid; Medhioub, Fatma Kaaniche; Allela, Rania; Algia, Najla Ben; Cherif, Samar; Slaoui, Mohamed Taoufik; Boubia, Souhail; Hafiani, Y.; Khaoudi, A.; Cherkab, R.; Elallam, W.; Elkettani, C.; Barrou, L.; Ridaii, M.; Mehdi, Rihi El; Schimpf, Caroline; Mizrahi, Assaf; Pilmis, Benoît; Le Monnier, Alban; Tiercelet, Kelly; Cherin, Mélanie; Bruel, Cédric; Philippart, Francois; Bailly, Sébastien; Lucet, Jc; Lepape, Alain; L’hériteau, François; Aupée, Martine; Bervas, Caroline; Boussat, Sandrine; Berger-Carbonne, Anne; Machut, Anaïs; Savey, Anne; Timsit, Jean-François; Razazi, Keyvan; Rosman, Jérémy; de Prost, Nicolas; Carteaux, Guillaume; Jansen, Chloe; Decousser, Jean Winoc; Brun-Buisson, Christian; Dessap, Armand Mekontso; M’rad, Aymen; Ouali, Zouhour; Barghouth, Manel; Kouatchet, Achille; Mahieu, Rafael; Weiss, Emmanuel; Schnell, David; Zahar, Jean-Ralph; Artiguenave, Margaux; Sophie, Paktoris-Papine; Espinasse, Florence; Sayed, Faten El; Dinh, Aurélien; Charron, Cyril; Geri, Guillaume; Vieillard-Baron, Antoine; Repessé, Xavier; Kallel, Hatem; Mayence, Claire; Houcke, Stéphanie; Guegueniat, Pascal; Hommel, Didier; Dhifaoui, Kaouther; Hajjej, Zied; Fatnassi, Amira; Sellami, Walid; Labbene, Iheb; Ferjani, Mustapha; Dachraoui, Fahmi; Nakkaa, Sabrine; M’ghirbi, Abdelwaheb; Adhieb, Ali; Braiek, Dhouha Ben; Hraiech, Kmar; Ousji, Ali; Ouanes, Islem; Zaineb, Hammouda; Abdallah, Saousen Ben; Ouanes-Besbes, Lamia; Abroug, Fekri; Klein, Simon; Miquet, Mattéo; Thouret, Jean-Marc; Peigne, Vincent; Daban, Jean-Louis; Boutonnet, Mathieu; Lenoir, Bernard; Merhbene, Takoua; Derreumaux, Celine; Seguin, Thierry; Conil, Jean-Marie; Kelway, Charlotte; Blasco, Valery; Nafati, Cyril; Harti, Karim; Reydellet, Laurent; Albanese, Jacques; Aicha, Narjess Ben; Meddeb, Khaoula; Khedher, Ahmed; Ayachi, Jihene; Fraj, Nesrine; Sma, Nesrine; Chouchene, Imed; Boussarsar, Mohamed; Yedder, Soumaya Ben; Samoud, Walid; Radhouene, Bousselmi; Mariem, Bousselmi; Ammar, Asma; Cheikh, Asma Ben; Lakhal, Hend Ben; Khelfa, Messaouda; Hamdaoui, Yamina; Bouafia, Nabiha; Trampont, Timothée; Daix, Thomas; Legarçon, Vincent; Karam, Henri Hani; Pichon, Nicolas; Essafi, Fatma; Foudhaili, Nasreddine; Thabet, Hafedh; Blel, Youssef; Brahmi, Nozha; Ezzouine, Hanane; Kerrous, Mahmoud; Haoui, Saad El; Ahdil, Soufiane; Benslama, Abdellatif; Abidi, Khalid; Dendane, Tarek; Oussama, Ssouni; Belayachi, Jihane; Madani, Naoufal; Abouqal, Redouane; Zeggwagh, Amine Ali; Ghadhoune, Hatem; Chaari, Anis; Jihene, Guissouma; Allouche, Hend; Trabelsi, Insaf; Brahmi, Habib; Samet, Mohamed; Ghord, Hatem El; Habiba, Ben Sik Ali; Hajer, Nouira; Tilouch, Najla; Yaakoubi, Sondes; Jaoued, Oussama; Gharbi, Rim; Hassen, Mohamed Fekih; Elatrous, Souheil; Arcizet, Julien; Leroy, Bertrand; Abdulmalack, Caroline; Renzullo, Catherine; Hamet, Maël; Doise, Jean-Marc; Coutet, Jérôme; Cheikh, Chaigar Mohammed; Quechar, Zakaria; Joris, Magalie; Beauport, Dimitri Titeca; Kontar, Loay; Lebon, Delphine; Gruson, Bérengère; Slama, Michel; Marolleau, Jean-Pierre; Maizel, Julien; Gorham, Julie; Ameye, Lieveke; Berghmans, Thierry; Paesmans, Marianne; Sculier, Jean-Paul; Meert, Anne-Pascale; Guillot, Max; Ledoux, Marie-Pierre; Braun, Thierry; Maestraggi, Quentin; Michard, Baptiste; Castelain, Vincent; Herbrecht, Raoul; Schneider, Francis; Couffin, Severine; Lobo, David; Mongardon, Nicolas; Dhonneur, Gilles; Mounier, Roman; Le Borgne, Pierrick; Couraud, Sophie; Herbrecht, Jean-Etienne; Boivin, Alexandra; Lefebvre, François; Bilbault, Pascal; Zelmat, Setti-Aouicha; Batouche, Djamila-Djahida; Mazour, Fatima; Chaffi, Belkacem; Benatta, Nadia; Sik, Ali Habiba; Talik, I.; Perrier, Maxime; Gouteix, Eliane; Koubi, Claude; Escavy, Annabelle; Guilbaut, Victoria; Fosse, Jean-Philippe; Jazia, Rahma Ben; Abdelghani, Ahmed; Cungi, Pierre-Julien; Bordes, Julien; Nguyen, Cédric; Pierrou, Candice; Cruc, Maximilien; Benois, Alain; Duprez, Frédéric; Bonus, Thierry; Cuvelier, Grégory; Ollieuz, Sandra; Machayekhi, Sharam; Paciorkowski, Frédéric; Reychler, Gregory; Coudroy, Remi; Thille, Arnaud W.; Drouot, Xavier; Diaz, Véronique; Meurice, Jean-Claude; Robert, René; Turki, Olfa; Ben, Hmida Chokri; Assefi, Mona; Deransy, Romain; Brisson, Hélène; Monsel, Antoine; Conti, Filomena; Scatton, Olivier; Langeron, Olivier; Ghezala, Hassen Ben; Snouda, Salah; Ben, Chiekh Imen; Kaddour, Moez; Armel, Anwar; Youness, Lafrikh; Abdelhak, Bensaid; Youssef, Miloudi; Najib, Al Harrar; Mustapha, Amouzoun; Noufel, Mtioui; Mohamed, Zamd; Salma, El Khayat; Ghizlane, Medkouri; Mohamed, Benghanam; Benyounes, Ramdani; Montini, Florent; Moschietto, Sébastien; Gregoire, Emilien; Claisse, Guillaume; Guiot, Julien; Morimont, Philippe; Krzesinski, Jean-Marie; Mariat, Christophe; Lambermont, Bernard; Cavalier, Etienne; Delanaye, Pierre; Benbernou, Soumia; Ilies, Sofiane; Azza, Abdelkader; Bouyacoub, Khalida; Louail, Meriem; Mokhtari-Djebli, Houria; Arrestier, Romain; Daviaud, Fabrice; Francois, Xavier Laborne; Brocas, Elsa; Choukroun, Gérald; Peñuelas, Oscar; Lorente, José-Angel; Cardinal-Fernandez, Pablo; Rodriguez, José-Maria; Aramburu, José-Antonio; Esteban, Andres; Frutos-Vivar, Fernando; Bitker, Laurent; Costes, Nicolas; Le Bars, Didier; Lavenne, Franck; Devouassoux, Mojgan; Richard, Jean-Christophe; Mechati, Malika; Gainnier, Marc; Papazian, Laurent; Guervilly, Christophe; Garnero, Aude; Arnal, Jean Michel; Roze, Hadrien; Richard, Jean Christophe; Repusseau, Benjamin; Dewitte, Antoine; Joannes-Boyau, Olivier; Ouattara, Alexandre; Harbouze, Nadia; Amine, A. M.; Olandzobo, A. G.; Herbland, Alexandre; Richard, Marie; Girard, Nicolas; Lambron, Lucile; Lesieur, Olivier; Wainschtein, Sarah; Hubert, Sidonie; Hugues, Albane; Tran, Marc; Bouillard, Philippe; Loteanu, Vlad; Leloup, Maxime; Laurent, Alexandra; Lheureux, Florent; Prestifilippo, Alessia; Cruz, Martin Delgado Maria; Romain, Rigal; Antonelli, Massimo; Blanch, Torra Lluis; Bonnetain, Franck; Grazzia-Bocci, Maria; Mancebo, Jordi; Samain, Emmanuel; Paul, Hebert; Capellier, Gilles; Zavgorodniaia, Taissa; Soichot, Marion; Malissin, Isabelle; Voicu, Sebastian; Garçon, Pierre; Goury, Antoine; Kerdjana, Lamia; Deye, Nicolas; Bourgogne, Emmanuel; Megarbane, Bruno; Mejri, Olfa; Hmida, Marwa Ben; Tannous, Salma; Chevillard, Lucie; Labat, Laurence; Risede, Patricia; Fredj, Hana; Léger, Maxime; Brunet, Marion; Le Roux, Gaël; Boels, David; Lerolle, Nicolas; Farah, Souaad; Amiel-Niemann, Hélène; Kubis, Nathalie; Declèves, Xavier; Peyraux, Nicoals; Baud, Frederic; Serafini, Micaela; Alvarez, Jean-Claude; Heinzelman, Annette; Jozwiak, Mathieu; Millasseau, Sandrine; Teboul, Jean-Louis; Alphonsine, Jean-Emmanuel; Depret, François; Richard, Nathalie; Attal, Pierre; Richard, Christian; Monnet, Xavier; Chemla, Denis; Jerbi, Salma; Khedhiri, Wafa; Necib, Hatem; Scarfo, Paolo; Chevalier, Charles; Piagnerelli, Michael; Lafont, Alexandre; Galy, Antoine; Mancia, Claire; Zerhouni, Amel; Tabeliouna, Kheira; Gaja, Ali; Hamrouni, Bassem; Malouch, Abir; Fourati, Sami; Messaoud, Rihab; Zarrouki, Youssef; Ziadi, Amra; Rhezali, Manal; Zouizra, Zahira; Boumzebra, Drissi; Samkaoui, Mohamed Abdennasser; Brunet, Jennifer; Canoville, Bertrand; Verrier, Pierre; Ivascau, Calin; Seguin, Amélie; Valette, Xavier; Du Cheyron, Damien; Daubin, Cedric; Bougouin, Wulfran; Aissaoui, Nadia; Lamhaut, Lionel; Jost, Daniel; Maupain, Carole; Beganton, Frankie; Bouglé, Adrien; Dumas, Florence; Marijon, Eloi; Jouven, Xavier; Cariou, Alain; Poirson, Florent; Chaput, Ulriikka; Beeken, Thomas; Maxime, Leclerc; Haikel, Oueslati; Vodovar, Dominique; Chelly, Jonathan; Marteau, Philippe; Chocron, Richard; Juvin, Philippe; Loeb, Thomas; Adnet, Frederic; Lecarpentier, Eric; Riviere, Antoine; De Cagny, Bertand; Soupison, Thierry; Privat, Elodie; Escutnaire, Joséphine; Dumont, Cyrielle; Baert, Valentine; Vilhelm, Christian; Hubert, Hervé; Leteurtre, Stéphane; Fresco, Marion; Bubenheim, Michael; Beduneau, Gaetan; Carpentier, Dorothée; Grange, Steven; Artaud-Macari, Elise; Misset, Benoit; Tamion, Fabienne; Girault, Christophe; Dumas, Guillaume; Chevret, Sylvie; Lemiale, Virginie; Mokart, Djamel; Mayaux, Julien; Pène, Frédéric; Nyunga, Martine; Perez, Pierre; Moreau, Anne-Sophie; Bruneel, Fabrice; Vincent, François; Klouche, Kada; Reignier, Jean; Rabbat, Antoine; Azoulay, Elie; Frat, Jean-Pierre; Ragot, Stéphanie; Constantin, Jean-Michel; Prat, Gwenael; Mercat, Alain; Boulain, Thierry; Demoule, Alexandre; Devaquet, Jérôme; Nseir, Saad; Charpentier, Julien; Argaud, Laurent; Beuret, Pascal; Ricard, Jean-Damien; Teiten, Christelle; Marjanovic, Nicolas; Palamin, Nicola; L’Her, Erwan; Bailly, Arthur; Boisramé-Helms, Julie; Champigneulle, Benoit; Kamel, Toufik; Mercier, Emmanuelle; Le Thuaut, Aurélie; Lascarrou, Jean-Baptiste; Rolle, Amélie; De Jong, Audrey; Chanques, Gérald; Jaber, Samir; Hariri, Geoffroy; Baudel, Jean-Luc; Dubée, Vincent; Preda, Gabriel; Bourcier, Simon; Joffre, Jeremie; Bigé, Naïke; Ait-Oufella, Hafid; Maury, Eric; Mater, Houda; Merdji, Hamid; Grimaldi, David; Rousseau, Christophe; Mira, Jean-Paul; Chiche, Jean-Daniel; Sedghiani, Ines; Benabderrahim, A.; Hamdi, Dhekra; Jendoubi, Asma; Cherif, Mohamed Ali; Hechmi, Youssef Zied El; Zouheir, Jerbi; Bagate, François; Bousselmi, Radhwen; Schortgen, Frédérique; Asfar, Pierre; Guérot, Emmanuel; Fabien, Grelon; Anguel, Nadia; Sigismond, Lasocki; Matthieu, Henry-Lagarrigue; Gonzalez, Frédéric; François, Legay; Guitton, Christophe; Schenck, Maleka; Jean-Marc, Doise; Dreyfuss, Didier; Radermacher, Peter; Frère, Antoine; Martin-Lefèvre, Laurent; Colin, Gwenhaël; Fiancette, Maud; Henry-Laguarrigue, Matthieu; Lacherade, Jean-Claude; Lebert, Christine; Vinatier, Isabelle; Yehia, Aihem; Joret, Aurélie; Menunier-Beillard, Nicolas; Benzekri-Lefevre, Dalila; Desachy, Arnaud; Bellec, Fréderic; Plantefève, Gaëtan; Quenot, Jean-Pierre; Meziani, Ferhat; Tavernier, Elsa; Ehrmann, Stephan; Chudeau, Nicolas; Raveau, Tommy; Moal, Valérie; Houillier, Pascal; Rouve, Emmanuelle; Lakhal, Karim; Gandonnière, Charlotte Salmon; Jouan, Youenn; Bodet-Contentin, Laetitia; Balmier, Adrien; Messika, Jonathan; De Montmollin, Etienne; Pouyet, Victorine; Sztrymf, Benjamin; Thiagarajah, Abirami; Roux, Damien; De Chambrun, Marc Pineton; Luyt, Charles-Edouard; Beloncle, François; Zapella, Nathalie; Ledochowsky, Stanislas; Terzi, Nicolas; Mazou, Jean-Marc; Sonneville, Romain; Paulus, Sylvie; Fedun, Yannick; Landais, Mickael; Raphalen, Jean-Herlé; Combes, Alain; Amoura, Zahir; Jacquemin, Aemilia; Guerrero, Felipe; Marcheix, Bertrand; Hernandez, Nicolas; Fourcade, Olivier; Georges, Bernard; Delmas, Clément; Makoudi, Sarah; Genton, Audrey; Bernard, Rémy; Lebreton, Guillaume; Amour, Julien; Mazet, Charlotte; Bounes, Fanny; Murat, Gurbuz; Cronier, Laure; Robin, Guillaume; Biendel, Caroline; Silva, Stein; Boubeche, Samia; Abriou, Caroline; Wurtz, Véronique; Scherrer, Vincent; Rey, Nathalie; Gastaldi, Gioia; Veber, Benoit; Doguet, Fabien; Gay, Arnaud; Dureuil, Bertrand; Besnier, Emmanuel; Rouget, Antoine; Gantois, Guillaume; Magalhaes, Eric; Wanono, Ruben; Smonig, Roland; Lermuzeaux, Mathilde; Lebut, Jordane; Olivier, Andremont; Dupuis, Claire; Radjou, Aguila; Mourvillier, Bruno; Neuville, Mathilde; D’ortho, Marie Pia; Bouadma, Lila; Rouvel-Tallec, Anny; Rudler, Marika; Weiss, Nicolas; Perlbarg, Vincent; Galanaud, Damien; Thabut, Dominique; Rachdi, Emna; Mhamdi, Ghada; Trifi, Ahlem; Abdelmalek, Rim; Abdellatif, Sami; Daly, Foued; Nasri, Rochdi; Tiouiri, Hanene; Lakhal, Salah Ben; Rousseau, Geoffroy; Asmolov, Romain; Grammatico-Guillon, Leslie; Auvet, Adrien; Laribi, Said; Garot, Denis; Dequin, Pierre François; Guillon, Antoine; Fergé, Jean-Louis; Abgrall, Gwénolé; Hinault, Ronan; Vally, Shazima; Roze, Benoit; Chaplain, Agathe; Chabartier, Cyrille; Savidan, Anne-Charlotte; Marie, Sabia; Cabie, Andre; Resiere, Dabor; Valentino, Ruddy; Mehdaoui, Hossein; Benarous, Lucas; Soda-Diop, Marième; Bouzana, Fouad; Perrin, Gilles; Bourenne, Jeremy; Eon, Béatrice; Lambert, Dominique; Trebuchon, Agnes; Poncelet, Géraldine; Le Bourgeois, Fleur; Michael, Levy; Camille, Guillot; Naudin, Jérôme; Deho, Anna; Dauger, Stéphane; Sauthier, Michaël; Bergeron-Gallant, Krystale; Emeriaud, Guillaume; Jouvet, Philippe; Tiebergien, Nicolas; Jacquet-Lagrèze, Matthias; Fellahi, Jean-Luc; Baudin, Florent; Essouri, Sandrine; Javouhey, Etienne; Guérin, Claude; Lampin, Marie; Mamouri, Ouardia; Devos, Patrick; Karaca-Altintas, Yasemin; Vinchon, Matthieu; Brossier, David; Eltaani, Redha; Teyssedre, Sonia; Sabine, Meyet; Bouchut, Jean-Christophe; Peguet, Olivier; Petitdemange, Lucie; Guilbert, Anne Sophie; Aoul, Nabil Tabet; Addou, Zakaria; Aouffen, Nabil; Anas, Benqqa; Kalouch, Samira; Yaqini, Khalid; Chlilek, Aziz; Abdou, Rchi; Gravellier, Perrine; Chantreuil, Julie; Travers, Nadine; Listrat, Antoine; Le Reun, Claire; Favrais, Geraldine; Coppere, Zoe; Blanot, Stéphane; Montmayeur, Juliette; Bronchard, Régis; Rolando, Stephane; Orliaguet, Gilles; Leger, Pierre-Louis; Rambaud, Jérôme; Thueux, Emilie; De Larrard, Alexandra; Berthelot, Véronique; Denot, Julien; Reymond, Marie; Amblard, Alain; Morin-Zorman, Sarah; Lengliné, Etienne; Pichereau, Claire; Mariotte, Eric; Emmanuel, Canet; Poujade, Julien; Trumpff, Guillaume; Janssen-Langenstein, Ralf; Harlay, Marie-Line; Zaid, Noorah; Ait-Ammar, Nawel; Bonnal, Christine; Merle, Jean-Claude; Botterel, Francoise; Levesque, Eric; Riad, Zakaria; Mezidi, Mehdi; Yonis, Hodane; Aublanc, Mylène; Perinel-Ragey, Sophie; Lissonde, Floriane; Louf-Durier, Aurore; Tapponnier, Romain; Louis, Bruno; Forel, Jean-Marie; Bisbal, Magali; Lehingue, Samuel; Rambaud, Romain; Adda, Mélanie; Hraiech, Sami; Marchi, Elisa; Roch, Antoine; Guerin, Vincent; Rozencwajg, Sacha; Schmidt, Matthieu; Hekimian, Guillaume; Bréchot, Nicolas; Trouillet, Jean Louis; Besset, Sébastien; Franchineau, Guillaume; Nieszkowska, Ania; Pascal, Leprince; Loiselle, Maud; Sarah, Chemam; Laurence, Dangers; Guillemette, Thomas; Jacquens, Alice; Kerever, Sebastien; Guidet, Bertrand; Aegerter, Philippe; Das, Vincent; Fartoukh, Muriel; Hayon, Jan; Desmard, Mathieu; Fulgencio, Jean-Pierre; Zuber, Benjamin; Soufi, A.; Khaleq, K.; Hamoudi, D.; Garret, Charlotte; Peron, Matthieu; Coron, Emmanuel; Bretonnière, Cédric; Audureau, Etienne; Audrey, Winters; Christophe, Duvoux; Christian, Jacquelinet; Daniel, Azoulay; Cyrille, Feray; Aissaoui, Wissal; Rghioui, Kawtar; Haddad, Wafae; Barrou, Houcine; Carteaux-Taeib, Anna; Lupinacci, Renato; Manceau, Gilles; Jeune, Florence; Tresallet, Christophe; Habacha, Sahar; Fathallah, Ines; Zoubli, Aymen; Aloui, Rafaa; Kouraichi, Nadia; Jouet, Emilie; Badin, Julie; Fermier, Brice; Feller, Marc; Serie, Mathieu; Pillot, Jérôme; Marie, William; Gisbert-Mora, Chloé; Vinclair, Camille; Lesbordes, Pierre; Mathieu, Pascal; De Brabant, Fabienne; Muller, Emmanuel; Robaux, Marie-Aline; Giabicani, Mikhael; Marchalot, Antoine; Gelinotte, Stéphanie; Declercq, Pierre Louis; Eraldi, Jean-Pierre; Bougerol, François; Meunier-Beillard, Nicolas; Devilliers, Hervé; Rigaud, Jean-Philippe; Verrière, Camille; Ardisson, Fanny; Kentish-Barnes, Nancy; Jacq, Gwenaëlle; Chermak, Akli; Lautrette, Alexandre; Legrand, Matthieu; Soummer, Alexis; Thiery, Guillaume; Cottereau, Alice; Canet, Emmanuel; Caujolle, Marie; Allyn, Jérôme; Valance, Dorothée; Brulliard, Caroline; Martinet, Olivier; Jabot, Julien; Gallas, Thomas; Vandroux, David; Allou, Nicolas; Durand, Arthur; Nevière, Rémi; Delguste, Florian; Boulanger, Eric; Preau, Sebastien; Martin, Ruste; Cochet, Hélène; Ponthus, Jean Pierre; Amilien, Virginie; Tchir, Martial; Barsam, Elise; Ayoub, Mohsen; Georger, Jean Francois; Guillame, Izaute; Assaraf, Julie; Tripon, Simona; Mallet, Maxime; Barbara, Guilaume; Louis, Guillaume; Gaudry, Stéphane; Barbarot, Nicolas; Jamet, Angéline; Outin, Hervé; Gibot, Sébastien; Bollaert, Pierre-Edouard; Holleville, Mathilde; Legriel, Stéphane; Chateauneuf, Anne Laure; Cavelot, Sébastien; Moyer, Jean-Denis; Bedos, Jean Pierre; Merle, Philippe; Laine, Aurelie; Natalie, De Sa; Cornuault, Mathieu; Libot, Jérome; Asehnoune, Karim; Rozec, Bertrand; Dantal, Jacques; Videcoq, Michel; Degroote, Thècle; Jaillette, Emmanuelle; Zerimech, Farid; Malika, Balduyck; Llitjos, Jean-François; Amara, Marlène; Lacave, Guillaume; Pangon, Béatrice; Mavinga, José; Makunza, Joseph Nsiala; Mafuta, M. E.; Yanga, Yves; Eric, Amisi; Ilunga, Jp; Kilembe, Ma; Alby-Laurent, Fanny; Toubiana, Julie; Mokline, Amel; Laajili, Achraf; Amri, Helmi; Rahmani, Imene; Mensi, Nidhal; Gharsallah, Lazheri; Tlaili, Sofiene; Gasri, Bahija; Hammouda, Rym; Messadi, Amen Allah; Allain, Pierre-Antoine; Gault, Nathallie; Paugam-Burtz, Catherine; Foucrier, Arnaud; Chatbri, Bassem; Bourbiaa, Yousra; Thabet, Lamia; Neuschwander, Arthur; Vincent, Looten; Beck, Jennifer; Vibol, Chhor; Amelie, Yavchitz; Resche-Rigon, Matthieu; Pirracchio, Jean MantzRomain; Bureau, Côme; Decavèle, Maxens; Campion, Sébastien; Ainsouya, Roukia; Niérat, Marie-Cécile; Prodanovic, Hélène; Raux, Mathieu; Similowski, Thomas; Dubé, Bruno-Pierre; Demiri, Suela; Dres, Martin; May, Faten; Quintard, Hervé; Kounis, Ilias; Saliba, Faouzi; André, Stephane; Boudon, Marc; Ichai, Philippe; Younes, Aline; Nakad, Lionel; Coilly, Audrey; Antonini, Teresa; Sobesky, Rodolphe; De Martin, Eleonora; Samuel, Didier; Hubert, Noemie; Nay, Mai-Anh; Auchabie, Johann; Giraudeau, Bruno; Jean, Reignier; Darmon, Michaël; Ruckly, Stephane; Garrouste-Orgeas, Maïté; Gratia, Elisabeth; Goldgran-Toledano, Dany; Jamali, Samir; Dumenil, Anne Sylvie; Schwebel, Carole; Brisard, Laurent; Bizouarn, Philippe; Lepoivre, Thierry; Nicolet, Johanna; Rigal, Jean Christophe; Roussel, Jean Christian; Cheurfa, Cherifa; Abily, Julien; Lescot, Thomas; Page, Isaline; Warnier, Stéphanie; Nys, Monique; Rousseau, Anne-Françoise; Damas, Pierre; Uhel, Fabrice; Lesouhaitier, Mathieu; Grégoire, Murielle; Gaudriot, Baptiste; Gacouin, Arnaud; Le Tulzo, Yves; Flecher, Erwan; Tarte, Karin; Tadié, Jean-Marc; Georges, Quentin; Soares, M.; Jeon, Kyeongman; Oeyen, Sandra; Rhee, Chin Kook; Gruber, Pascale; Ostermann, Marlies; Hill, Quentin; Depuydt, Peter; Ferra, Christelle; Muller, Alice; Aurelie, Bourmaud; Niles, Christopher; Herbert, Fabien; Pied, Sylviane; Loridant, Séverine; François, Nadine; Bignon, Anne; Sendid, Boualem; Lemaitre, Caroline; Dupre, Celine; Zayene, Aymen; Portier, Lucie; De Freitas Caires, Nathalie; Lassalle, Philippe; Le Neindre, Aymeric; Selot, Pascal; Ferreiro, Daniel; Bonarek, Maria; Henriot, Stépahen; Rodriguez, Julie; Taddei, Mara; Di Bari, Mauro; Hickmann, Cheryl; Castanares-Zapatero, Diego; Deldicque, Louise; Van Den Bergh, Peter; Caty, Gilles; Roeseler, Jean; Francaux, Marc; Laterre, Pierre-François; Dupuis, Bastien; Machayeckhi, Sharam; Sarfati, Celine; Moore, Alex; Mendialdua, Paula; Rodet, Emilie; Pilorge, Catherine; Stephan, Francois; Rezaiguia-Delclaux, Saida; Dugernier, Jonathan; Hesse, Michel; Jumetz, Thibaud; Bialais, Emilie; Depoortere, Virginie; Michotte, Jean Bernard; Wittebole, Xavier; Jamar, François title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 journal: Ann Intensive Care DOI: 10.1186/s13613-016-0224-7 sha: doc_id: 14538 cord_uid: 6a2pviol file: cache/cord-005881-oswgjaxz.json key: cord-005881-oswgjaxz authors: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-010-8888-z sha: doc_id: 5881 cord_uid: oswgjaxz file: cache/cord-015082-l629n8is.json key: cord-015082-l629n8is authors: nan title: Poster Sessions 323-461 date: 2002-08-29 journal: Intensive Care Med DOI: 10.1007/s00134-002-1455-7 sha: doc_id: 15082 cord_uid: l629n8is file: cache/cord-014996-p6q0f37c.json key: cord-014996-p6q0f37c authors: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 journal: Intensive Care Med DOI: 10.1007/s00134-009-1593-2 sha: doc_id: 14996 cord_uid: p6q0f37c file: cache/cord-011062-ukz4hnmy.json key: cord-011062-ukz4hnmy authors: nan title: Poster date: 2020-03-11 journal: J Frailty Aging DOI: 10.14283/jfa.2020.9 sha: doc_id: 11062 cord_uid: ukz4hnmy file: cache/cord-014516-r59usk02.json key: cord-014516-r59usk02 authors: nan title: Research Communications of the 24th ECVIM‐CA Congress date: 2015-01-10 journal: J Vet Intern Med DOI: 10.1111/jvim.12491 sha: doc_id: 14516 cord_uid: r59usk02 file: cache/cord-016559-tqd7m2i1.json key: cord-016559-tqd7m2i1 authors: Zheng, Yi; Zhang, Xuewen; Guo, Jiaoli title: Application in Medicine Systems date: 2014-10-28 journal: Dan Shen (Salvia miltiorrhiza) in Medicine DOI: 10.1007/978-94-017-9466-4_1 sha: doc_id: 16559 cord_uid: tqd7m2i1 file: cache/cord-018813-9hoksa86.json key: cord-018813-9hoksa86 authors: Waito, Marianne; Walsh, Scott R.; Rasiuk, Alexandra; Bridle, Byram W.; Willms, Allan R. title: A Mathematical Model of Cytokine Dynamics During a Cytokine Storm date: 2016-02-17 journal: Mathematical and Computational Approaches in Advancing Modern Science and Engineering DOI: 10.1007/978-3-319-30379-6_31 sha: doc_id: 18813 cord_uid: 9hoksa86 file: cache/cord-015126-cyhcbk1j.json key: cord-015126-cyhcbk1j authors: nan title: PS 0036-0344 date: 2007-08-25 journal: Intensive Care Med DOI: 10.1007/s00134-007-0820-y sha: doc_id: 15126 cord_uid: cyhcbk1j file: cache/cord-017067-19eawrjt.json key: cord-017067-19eawrjt authors: Ogbondah, Chris Wolumati; Agbese, Pita Ogaba title: Terrorists and Social Media Messages: A Critical Analysis of Boko Haram’s Messages and Messaging Techniques date: 2017-10-24 journal: The Palgrave Handbook of Media and Communication Research in Africa DOI: 10.1007/978-3-319-70443-2_18 sha: doc_id: 17067 cord_uid: 19eawrjt file: cache/cord-014533-6qfecv5h.json key: cord-014533-6qfecv5h authors: Velasquez, T.; Mackey, G.; Lusk, J.; Kyle, U. G.; Fontenot, T.; Marshall, P.; Shekerdemian, L. S.; Coss-Bu, J. A.; Nishigaki, A.; Yatabe, T.; Tamura, T.; Yamashita, K.; Yokoyama, M.; Ruiz-Rodriguez, J. C.; Encina, B.; Belmonte, R.; Troncoso, I.; Tormos, P.; Riveiro, M.; Baena, J.; Sanchez, A.; Bañeras, J.; Cordón, J.; Duran, N.; Ruiz, A.; Caballero, J.; Nuvials, X.; Riera, J.; Serra, J.; Rutten, A. M. F.; van Ieperen, S. N. M.; Der Kinderen, E. P. H. M.; Van Logten, T.; Kovacikova, L.; Skrak, P.; Zahorec, M.; Kyle, U. G.; Akcan-Arikan, A.; Silva, J. C.; Mackey, G.; Lusk, J.; Goldsworthy, M.; Shekerdemian, L. S.; Coss-Bu, J. A.; Wood, D.; Harrison, D.; Parslow, R.; Davis, P.; Pappachan, J.; Goodwin, S.; Ramnarayan, P.; Chernyshuk, S.; Yemets, H.; Zhovnir, V.; Pulitano’, S. M.; De Rosa, S.; Mancino, A.; Villa, G.; Tosi, F.; Franchi, P.; Conti, G.; Patel, B.; Khine, H.; Shah, A.; Sung, D.; Singer, L.; Haghbin, S.; Inaloo, S.; Serati, Z.; Idei, M.; Nomura, T.; Yamamoto, N.; Sakai, Y.; Yoshida, T.; Matsuda, Y.; Yamaguchi, Y.; Takaki, S.; Yamaguchi, O.; Goto, T.; Longani, N.; Medar, S.; Abdel-Aal, I. R.; El Adawy, A. S.; Mohammed, H. M. E. H.; Mohamed, A. N.; Parry, S. M.; Knight, L. D.; Denehy, L.; De Morton, N.; Baldwin, C. E.; Sani, D.; Kayambu, G.; da Silva, V. Z. M.; Phongpagdi, P.; Puthucheary, Z. A.; Granger, C. L.; Rydingsward, J. E.; Horkan, C. M.; Christopher, K. B.; McWilliams, D.; Jones, C.; Reeves, E.; Atkins, G.; Snelson, C.; Aitken, L. M.; Rattray, J.; Kenardy, J.; Hull, A. M.; Ullman, A.; Le Brocque, R.; Mitchell, M.; Davis, C.; Macfarlane, B.; Azevedo, J. C.; Rocha, L. L.; De Freitas, F. F. M.; Cavalheiro, A. M.; Lucinio, N. M.; Lobato, M. S.; Ebeling, G.; Kraegpoeth, A.; Laerkner, E.; De Brito-Ashurst, I.; White, C.; Gregory, S.; Forni, L. G.; Flowers, E.; Curtis, A.; Wood, C. A.; Siu, K.; Venkatesan, K.; Muhammad, J. B. H.; Ng, L.; Seet, E.; Baptista, N.; Escoval, A.; Tomas, E.; Agrawal, R.; Mathew, R.; Varma, A.; Dima, E.; Charitidou, E.; Perivolioti, E.; Pratikaki, M.; Vrettou, C.; Giannopoulos, A.; Zakynthinos, S.; Routsi, C.; Atchade, E.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Genève, C.; Tanaka, S.; Lortat-Jacob, B.; Augustin, P.; Desmard, M.; Montravers, P.; de Molina, F. J. González; Barbadillo, S.; Alejandro, R.; Álvarez-Lerma, F.; Vallés, J.; Catalán, R. M.; Palencia, E.; Jareño, A.; Granada, R. M.; Ignacio, M. L.; Cui, N.; Liu, D.; Wang, H.; Su, L.; Qiu, H.; Li, R.; Jaffal, K.; Rouzé, A.; Poissy, J.; Sendid, B.; Nseir, S.; Paramythiotou, E.; Rizos, M.; Frantzeskaki, F.; Antoniadou, A.; Vourli, S.; Zerva, L.; Armaganidis, A.; Riera, J.; Gottlieb, J.; Greer, M.; Wiesner, O.; Martínez, M.; Acuña, M.; Rello, J.; Welte, T.; Atchade, E.; Mignot, T.; Houzé, S.; Jean-Baptiste, S.; Thabut, G.; Lortat-Jacob, B.; Tanaka, S.; Augustin, P.; Desmard, M.; Montravers, P.; Soussi, S.; Dudoignon, E.; Ferry, A.; Chaussard, M.; Benyamina, M.; Alanio, A.; Touratier, S.; Chaouat, M.; Lafaurie, M.; Mimoun, M.; Mebazaa, A.; Legrand, M.; Sheils, M. A.; Patel, C.; Mohankumar, L.; Akhtar, N.; Noriega, S. K. Pacheco; Aldana, N. Navarrete; León, J. L. Ávila; Baquero, J. Durand; Bernal, F. Fernández; Ahmadnia, E.; Hadley, J. S.; Millar, M.; Hall, D.; Hewitt, H.; Yasuda, H.; Sanui, M.; Komuro, T.; Kawano, S.; Andoh, K.; Yamamoto, H.; Noda, E.; Hatakeyama, J.; Saitou, N.; Okamoto, H.; Kobayashi, A.; Takei, T.; Matsukubo, S.; Rotzel, H. B.; Lázaro, A. Serrano; Prada, D. Aguillón; Gimillo, M. Rodriguez; Barinas, O. Diaz; Cortes, M. L. Blasco; Franco, J. Ferreres; Roca, J. M. Segura; Carratalá, A.; Gonçalves, B.; Turon, R.; Mendes, A.; Miranda, F.; Mata, P. J.; Cavalcanti, D.; Melo, N.; Lacerda, P.; Kurtz, P.; Righy, C.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Irazabal, J. M. Guergué; Spatenkova, V.; Bradac, O.; Suchomel, P.; Urli, T.; Lazzeri, E. Heusch; Aspide, R.; Zanello, M.; Perez-Borrero, L.; Garcia-Alvarez, J. M.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Rivera-Fernandez, R.; Mora-Ordoñez, J.; De La Fuente-Martos, C.; Castillo-Lorente, E.; Guerrero-Lopez, F.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Pertuz, E. D. Díaz; Hernández, A. Ansotegui; Romero, J. C. García; Sánchez, M. J. Gómez; Herrera, A. N. García; Ramírez, J. Roldán; Sanz, E. Regidor; Hualde, J. Barado; León, J. P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. L.; Pérez, H.; Calpe, P.; Alcala, M. A.; Robaglia, D.; Perez, C.; Lan, S. K.; Cunha, M. M.; Moreira, T.; Santos, F.; Lafuente, E.; Fernandes, M. J.; Silva, J. G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Herrera, A. N. García; Romero, J. C. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Echeverría, J. G. Armando; Hernández, A. Ansotegui; Hualde, J. Barado; Podlepich, V.; Sokolova, E.; Alexandrova, E.; Lapteva, K.; Kurtz, P.; Shuinotsuka, C.; Rabello, L.; Vianna, G.; Reis, A.; Cairus, C.; Salluh, J.; Bozza, F.; Torres, J. C. Barrios; Araujo, N. J. Fernández; García-Olivares, P.; Keough, E.; Dalorzo, M.; Tang, L. K.; De Sousa, I.; Díaz, M.; Marcos-Zambrano, L. J.; Guerrero, J. E.; Gomez, S. E. Zamora; Lopez, G. D. Hernandez; Cuellar, A. I. Vazquez; Nieto, O. R. Perez; Gonzalez, J. A. Castanon; Bhasin, D.; Rai, S.; Singh, H.; Gupta, O.; Bhattal, M. K.; Sampley, S.; Sekhri, K.; Nandha, R.; Aliaga, F. A.; Olivares, F.; Appiani, F.; Farias, P.; Alberto, F.; Hernández, A.; Pons, S.; Sonneville, R.; Bouadma, L.; Neuville, M.; Mariotte, E.; Radjou, A.; Lebut, J.; Chemam, S.; Voiriot, G.; Dilly, M. P.; Mourvillier, B.; Dorent, R.; Nataf, P.; Wolff, M.; Timsit, J. F.; Ediboglu, O.; Ataman, S.; Ozkarakas, H.; Kirakli, C.; Vakalos, A.; Avramidis, V.; Obukhova, O.; Kurmukov, I. A.; Kashiya, S.; Golovnya, E.; Baikova, V. N.; Ageeva, T.; Haritydi, T.; Kulaga, E. V.; Rios-Toro, J. J.; Perez-Borrero, L.; Aguilar-Alonso, E.; Arias-Verdu, M. D.; Garcia-Alvarez, J. M.; Lopez-Caler, C.; De La Fuente-Martos, C.; Rodriguez-Fernandez, S.; Sanchez-Orézzoli, M. Gomez; Martin-Gallardo, F.; Nikhilesh, J.; Joshi, V.; Villarreal, E.; Ruiz, J.; Gordon, M.; Quinza, A.; Gimenez, J.; Piñol, M.; Castellanos, A.; Ramirez, P.; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Shah, H.; Kellner, F.; Rezai, F.; Mistry, N.; Yodice, P.; Ovnanian, V.; Fless, K.; Handler, E.; Alejos, R. Martínez; Romeu, J. D. Martí; Antón, D. González; Quinart, A.; Martí, A. Torres; Llaurado-Serra, M.; Lobo-Civico, A.; Ventura-Rosado, A.; Piñol-Tena, A.; Pi-Guerrero, M.; Paños-Espinosa, C.; Peralvo-Bernat, M.; Marine-Vidal, J.; Gonzalez-Engroba, R.; Montesinos-Cerro, N.; Treso-Geira, M.; Valeiras-Valero, A.; Martinez-Reyes, L.; Sandiumenge, A.; Jimenez-Herrera, M. F.; Helyar, S.; Riozzi, P.; Noon, A.; Hallows, G.; Cotton, H.; Keep, J.; Hopkins, P. A.; Taggu, A.; Renuka, S.; Sampath, S.; Rood, P. J. T.; Frenzel, T.; Verhage, R.; Bonn, M.; Pickkers, P.; van der Hoeven, J. G.; van den Boogaard, M.; Corradi, F.; Melnyk, L.; Moggia, F.; Pienovi, R.; Adriano, G.; Brusasco, C.; Mariotti, L.; Lattuada, M.; Bloomer, M. J.; Coombs, M.; Ranse, K.; Endacott, R.; Maertens, B.; Blot, K.; Blot, S.; Amerongen, M. P. van Nieuw; van der Heiden, E. S.; Twisk, J. W. R.; Girbes, A. R. J.; Spijkstra, J. J.; Riozzi, P.; Helyar, S.; Cotton, H.; Hallows, G.; Noon, A.; Bell, C.; Peters, K.; Feehan, A.; Keep, J.; Hopkins, P. A.; Churchill, K.; Hawkins, K.; Brook, R.; Paver, N.; Endacott, R.; Maistry, N.; van Wijk, A.; Rouw, N.; van Galen, T.; Evelein-Brugman, S.; Taggu, A.; Krishna, B.; Sampath, S.; Putzu, A.; Fang, M.; Berto, M. Boscolo; Belletti, A.; Cassina, T.; Cabrini, L.; Mistry, M.; Alhamdi, Y.; Welters, I.; Abrams, S. T.; Toh, C. H.; Han, H. S.; Gil, E. M.; Lee, D. S.; Park, C. M.; Winder-Rhodes, S.; Lotay, R.; Doyle, J.; Ke, M. W.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Shu, C. W.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Dubó, S.; Aquevedo, A.; Jibaja, M.; Berrutti, D.; Labra, C.; Lagos, R.; García, M. F.; Ramirez, V.; Tobar, M.; Picoita, F.; Peláez, C.; Carpio, D.; Alegría, L.; Hidalgo, C.; Godoy, K.; Bakker, J.; Hernández, G.; Sadamoto, Y.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Marin-Mateos, H.; Perez-Vela, J. L.; Garcia-Gigorro, R.; Peiretti, M. A. Corres; Lopez-Gude, M. J.; Chacon-Alves, S.; Renes-Carreño, E.; Montejo-González, J. C.; Parlevliet, K. L.; Touw, H. R. W.; Beerepoot, M.; Boer, C.; Elbers, P. W. G.; Tuinman, P. R.; Abdelmonem, S. A.; Helmy, T. A.; El Sayed, I.; Ghazal, S.; Akhlagh, S. H.; Masjedi, M.; Hozhabri, K.; Kamali, E.; Zýková, I.; Paldusová, B.; Sedlák, P.; Morman, D.; Youn, A. M.; Ohta, Y.; Sakuma, M.; Bates, D.; Morimoto, T.; Su, P. L.; Chang, W. Y.; Lin, W. C.; Chen, C. W.; Facchin, F.; Zarantonello, F.; Panciera, G.; De Cassai, A.; Venrdramin, A.; Ballin, A.; Tonetti, T.; Persona, P.; Ori, C.; Del Sorbo, L.; Rossi, S.; Vergani, G.; Cressoni, M.; Chiumello, D.; Chiurazzi, C.; Brioni, M.; Algieri, I.; Tonetti, T.; Guanziroli, M.; Colombo, A.; Tomic, I.; Colombo, A.; Crimella, F.; Carlesso, E.; Gasparovic, V.; Gattinoni, L.; Neto, A. Serpa; Schmidt, M.; Pham, T.; Combes, A.; de Abreu, M. Gama; Pelosi, P.; Schultz, M. J.; Katira, B. H.; Engelberts, D.; Giesinger, R. E.; Ackerley, C.; Yoshida, T.; Zabini, D.; Otulakowski, G.; Post, M.; Kuebler, W. M.; McNamara, P. J.; Kavanagh, B. P.; Pirracchio, R.; Rigon, M. Resche; Carone, M.; Chevret, S.; Annane, D.; Eladawy, S.; El-Hamamsy, M.; Bazan, N.; Elgendy, M.; De Pascale, G.; Vallecoccia, M. S.; Cutuli, S. L.; Di Gravio, V.; Pennisi, M. A.; Conti, G.; Antonelli, M.; Andreis, D. T.; Khaliq, W.; Singer, M.; Hartmann, J.; Harm, S.; Carmona, S. Alcantara; Almudevar, P. Matia; Abellán, A. Naharro; Ramos, J. Veganzones; Pérez, L. Pérez; Valbuena, B. Lobo; Sanz, N. Martínez; Simón, I. Fernández; Arrigo, M.; Feliot, E.; Deye, N.; Cariou, A.; Guidet, B.; Jaber, S.; Leone, M.; Resche-Rigon, M.; Baron, A. Vieillard; Legrand, M.; Gayat, E.; Mebazaa, A.; Balik, M.; Kolnikova, I.; Maly, M.; Waldauf, P.; Tavazzi, G.; Kristof, J.; Herpain, A.; Su, F.; Post, E.; Taccone, F.; Vincent, J. L.; Creteur, J.; Lee, C.; Hatib, F.; Jian, Z.; Buddi, S.; Cannesson, M.; Fileković, S.; Turel, M.; Knafelj, R.; Gorjup, V.; Stanić, R.; Gradišek, P.; Cerović, O.; Mirković, T.; Noč, M.; Tirkkonen, J.; Hellevuo, H.; Olkkola, K. T.; Hoppu, S.; Lin, K. C.; Hung, W. T.; Chiang, C. C.; Huang, W. C.; Juan, W. C.; Lin, S. C.; Cheng, C. C.; Lin, P. H.; Fong, K. Y.; Hou, D. S.; Kang, P. L.; Wann, S. R.; Chen, Y. S.; Mar, G. Y.; Liu, C. P.; Paul, M.; Bougouin, W.; Geri, G.; Dumas, F.; Champigneulle, B.; Legriel, S.; Charpentier, J.; Mira, J. P.; Sandroni, C.; Cariou, A.; Zimmerman, J.; Sullivan, E.; Noursadeghi, M.; Fox, B.; Sampson, D.; McHugh, L.; Yager, T.; Cermelli, S.; Seldon, T.; Bhide, S.; Brandon, R. A.; Brandon, R. B.; Zwaag, J.; Beunders, R.; Pickkers, P.; Kox, M.; Gul, F.; Arslantas, M. K.; Genc, D.; Zibandah, N.; Topcu, L.; Akkoc, T.; Cinel, I.; Greco, E.; Lauretta, M. P.; Andreis, D. T.; Singer, M.; Garcia, I. Palacios; Cordero, M.; Martin, A. Diaz; Pallás, T. Aldabó; Montero, J. Garnacho; Rey, J. Revuelto; Malo, L. Roman; Montoya, A. A. Tanaka; Martinez, A. D. C. Amador; Ayala, L. Y. Delgado; Zepeda, E. Monares; Granillo, J. Franco; Sanchez, J. Aguirre; Alejo, G. Camarena; Cabrera, A. Rugerio; Montenegro, A. Pedraza; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Soilemezi, E.; Koco, E.; Savvidou, S.; Nouris, C.; Matamis, D.; Di Mussi, R.; Spadaro, S.; Volta, C. A.; Mariani, M.; Colaprico, A.; Antonio, C.; Bruno, F.; Grasso, S.; Rodriguez, A.; Martín-Loeches, I.; Díaz, E.; Masclans, J. R.; Gordo, F.; Solé-Violán, J.; Bodí, M.; Avilés-Jurado, F. X.; Trefler, S.; Magret, M.; Reyes, L. F.; Marín-Corral, J.; Yebenes, J. C.; Esteban, A.; Anzueto, A.; Aliberti, S.; Restrepo, M. I.; Larsson, J. Skytte; Redfors, B.; Ricksten, S. E.; Haines, R.; Powell-Tuck, J.; Leonard, H.; Ostermann, M.; Berthelsen, R. E.; Itenov, T. S.; Perner, A.; Jensen, J. U.; Ibsen, M.; Jensen, A. E. K.; Bestle, M. H.; Bucknall, T.; Dixon, J.; Boa, F.; MacPhee, I.; Philips, B. J.; Doyle, J.; Saadat, F.; Samuels, T.; Huddart, S.; McCormick, B.; DeBrunnar, R.; Preece, J.; Swart, M.; Peden, C.; Richardson, S.; Forni, L.; Kalfon, P.; Baumstarck, K.; Estagnasie, P.; Geantot, M. A.; Berric, A.; Simon, G.; Floccard, B.; Signouret, T.; Boucekine, M.; Fromentin, M.; Nyunga, M.; Sossou, A.; Venot, M.; Robert, R.; Follin, A.; Renault, A.; Garrouste, M.; Collange, O.; Levrat, Q.; Villard, I.; Thévenin, D.; Pottecher, J.; Patrigeon, R. G.; Revel, N.; Vigne, C.; Mimoz, O.; Auquier, P.; Pawar, S.; Jacques, T.; Deshpande, K.; Pusapati, R.; Wood, B.; Pulham, R. A.; Wray, J.; Brown, K.; Pierce, C.; Nadel, S.; Ramnarayan, P.; Azevedo, J. R.; Montenegro, W. S.; Rodrigues, D. P.; Sousa, S. C.; Araujo, V. F.; Leitao, A. L.; Prazeres, P. H.; Mendonca, A. V.; Paula, M. P.; Das Neves, A.; Loudet, C. I.; Busico, M.; Vazquez, D.; Villalba, D.; Lischinsky, A.; Veronesi, M.; Emmerich, M.; Descotte, E.; Juliarena, A.; Bisso, M. Carboni; Grando, M.; Tapia, A.; Camargo, M.; Ulla, D. Villani; Corzo, L.; dos Santos, H. Placido; Ramos, A.; Doglia, J. A.; Estenssoro, E.; Carbonara, M.; Magnoni, S.; Donald, C. L. Mac; Shimony, J. S.; Conte, V.; Triulzi, F.; Stretti, F.; Macrì, M.; Snyder, A. Z.; Stocchetti, N.; Brody, D. L.; Podlepich, V.; Shimanskiy, V.; Savin, I.; Lapteva, K.; Chumaev, A.; Tjepkema-Cloostermans, M. C.; Hofmeijer, J.; Beishuizen, A.; Hom, H.; Blans, M. J.; van Putten, M. J. A. M.; Longhi, L.; Frigeni, B.; Curinga, M.; Mingone, D.; Beretta, S.; Patruno, A.; Gandini, L.; Vargiolu, A.; Ferri, F.; Ceriani, R.; Rottoli, M. R.; Lorini, L.; Citerio, G.; Pifferi, S.; Battistini, M.; Cordolcini, V.; Agarossi, A.; Di Rosso, R.; Ortolano, F.; Stocchetti, N.; Lourido, C. Mora; Cabrera, J. L. Santana; Santana, J. D. Martín; Alzola, L. Melián; del Rosario, C. García; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Eslami, S.; Dalhuisen, A.; Fiks, T.; Schultz, M. J.; Hanna, A. Abu; Spronk, P. E.; Wood, M.; Maslove, D.; Muscedere, J.; Scott, S. H.; Saha, T.; Hamilton, A.; Petsikas, D.; Payne, D.; Boyd, J. G.; Puthucheary, Z. A.; McNelly, A. S.; Rawal, J.; Connolly, B.; McPhail, M. J.; Sidhu, P.; Rowlerson, A.; Moxham, J.; Harridge, S. D.; Hart, N.; Montgomery, H. E.; Jovaisa, T.; Thomas, B.; Gupta, D.; Wijayatilake, D. S.; Shum, H. P.; King, H. S.; Chan, K. C.; Tang, K. B.; Yan, W. W.; Arias, C. Castro; Latorre, J.; De La Rica, A. Suárez; Garrido, E. Maseda; Feijoo, A. Montero; Gancedo, C. Hernández; Tofiño, A. López; Rodríguez, F. Gilsanz; Gemmell, L. K.; Campbell, R.; Doherty, P.; MacKay, A.; Singh, N.; Vitaller, S.; Nagib, H.; Prieto, J.; Del Arco, A.; Zayas, B.; Gomez, C.; Tirumala, S.; Pasha, S. A.; Kumari, B. K.; Martinez-Lopez, P.; Puerto-Morlán, A.; Nuevo-Ortega, P.; Pujol, L. Martinez; Dolset, R. Algarte; González, B. Sánchez; Riera, S. Quintana; Álvarez, J. Trenado; Quintana, S.; Martínez, L.; Algarte, R.; Sánchez, B.; Trenado, J.; Tomas, E.; Brock, N.; Viegas, E.; Filipe, E.; Cottle, D.; Traynor, T.; Martínez, M. V. Trasmonte; Márquez, M. Pérez; Gómez, L. Colino; Martínez, N. Arias; Muñoz, J. M. Milicua; Bellver, B. Quesada; Varea, M. Muñoz; Llorente, M. Á. Alcalá; Calvo, C. Pérez; Hillier, S. D.; Faulds, M. C.; Hendra, H.; Lawrence, N.; Maekawa, K.; Hayakawa, M.; Ono, Y.; Kodate, A.; Sadamoto, Y.; Tominaga, N.; Mizugaki, A.; Murakami, H.; Yoshida, T.; Katabami, K.; Wada, T.; Sawamura, A.; Gando, S.; Silva, S.; Kerhuel, L.; Malagurski, B.; Citerio, G.; Chabanne, R.; Laureys, S.; Puybasset, L.; Nobile, L.; Pognuz, E. R.; Rossetti, A. O.; Verginella, F.; Gaspard, N.; Creteur, J.; Ben-Hamouda, N.; Oddo, M.; Taccone, F. S.; Ono, Y.; Hayakawa, M.; Iijima, H.; Maekawa, K.; Kodate, A.; Sadamoto, Y.; Mizugaki, A.; Murakami, H.; Katabami, K.; Wada, T.; Sawamura, A.; Gando, S.; Kodate, A.; Katabami, K.; Wada, T.; Ono, Y.; Maekawa, K.; Hayakawa, M.; Sawamura, A.; Gando, S.; Andersen, L. W.; Raymond, T.; Berg, R.; Nadkarni, V.; Grossestreuer, A.; Kurth, T.; Donnino, M.; Krüger, A.; Ostadal, P.; Janotka, M.; Vondrakova, D.; Kongpolprom, N.; Cholkraisuwat, J.; Pekkarinen, P. T.; Ristagno, G.; Masson, S.; Latini, R.; Bendel, S.; Ala-Kokko, T.; Varpula, T.; Vaahersalo, J.; Hoppu, S.; Tiainen, M.; Mion, M. M.; Plebani, M.; Pettilä, V.; Skrifvars, M.B.; Son, Y.; Kim, K. S.; Suh, G. J.; Kwon, W. Y.; Ko, J. I.; Park, M. J.; Cavicchi, F. Zama; Iesu, E.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Tanaka, H.; Otani, N.; Ode, S.; Ishimatsu, S.; Martínez, L.; Algarte, R.; Sánchez, B.; Romero, I.; Martínez, F.; Quintana, S.; Trenado, J.; Vondrakova, D.; Ostadal, P.; Kruger, A.; Janotka, M.; Malek, F.; Neuzil, P.; Yeh, Y. C.; Chen, Y. S.; Wang, C. H.; Huang, C. H.; Chao, A.; Lee, C. T.; Lai, C. H.; Chan, W. S.; Cheng, Y. J.; Sun, W. Z.; Kaese, S.; Horstmann, C.; Lebiedz, P.; Mourad, M.; Gaudard, P.; Eliet, J.; Zeroual, N.; Colson, P.; Ostadal, P.; Mlcek, M.; Hrachovina, M.; Kruger, A.; Vondrakova, D.; Janotka, M.; Mates, M.; Hala, P.; Kittnar, O.; Neuzil, P.; Jacky, A.; Rudiger, A.; Spahn, D. R.; Bettex, D. A.; Kara, A.; Akin, S.; Dos reis Miranda, D.; Struijs, A.; Caliskan, K.; van Thiel, R. J.; Dubois, E. A.; de Wilde, W.; Zijlstra, F.; Gommers, D.; Ince, C.; Marca, L.; Xini, A.; Mongkolpun, W.; Cordeiro, C. P. R.; Leite, R. T.; Lheureux, O.; Bader, A.; Rincon, L.; Santacruz, C.; Preiser, J. C.; Chao, A.; Chao, A. S.; Chen, Y. S.; Kim, W.; Ahn, C.; Cho, Y.; Lim, T. H.; Oh, J.; Choi, K. S.; Jang, B. H.; Ha, J. K.; Mecklenburg, A.; Stamm, J.; Soeffker, G.; Kubik, M.; Sydow, K.; Reichenspurner, H.; Kluge, S.; Braune, S.; Bergantino, B.; Ruberto, F.; Magnanimi, E.; Privato, E.; Zullino, V.; Bruno, K.; Pugliese, F.; Sales, G.; Girotto, V.; Vittone, F.; Brazzi, L.; Fritz, C.; Kimmoun, A.; Vanhuyse, F.; Trifan, B.; Orlowski, S.; Albuisson, E.; Tran, N.; Levy, B.; Chhor, V.; Joachim, J.; Follin, A.; Champigneulle, B.; Chatelon, J.; Fave, G.; Mantz, J.; Pirracchio, R.; Diaz, D. Díaz; Villanova, M.; Aguirregabyria, M.; Andrade, G.; López, L.; Palencia, E.; John, G.; Cowan, R.; Hart, R.; Lake, K.; Litchfield, K.; Song, J. W.; Lee, Y. J.; Cho, Y. J.; Choi, S.; Vermeir, P.; Vandijck, D.; Blot, S.; Mariman, A.; Verhaeghe, R.; Deveugele, M.; Vogelaers, D.; Chok, L.; Bachli, E. B.; Bettex, D.; Cottini, S. R.; Keller, E.; Maggiorini, M.; Schuepbach, R.; Fiks, T.; Stiphout, C.; Grevelink, M.; Vaneker, I.; Ruijter, A.; Buise, M.; Spronk, P. E.; Tena, S. Altaba; Barrachina, L. Galarza; Portillo, J. H. Rodriguez; Aznar, G. Pagés; Campos, L. Mateu; Sellés, M. D. Ferrándiz; Tomás, M. Arlandis; Muncharaz, A. Belenguer; Skinner, L.; Monsalvo, S.; Olavarria, E.; Stümpfle, R.; Na, S. J.; Park, J.; Chung, C. R.; Park, C. M.; Suh, G. Y.; Yang, J. H.; Witter, T.; Brousseau, C.; Butler, M. B.; Erdogan, M.; Dougall, P. C. Mac; Green, R. S.; Abbott, T. E. F.; Torrance, H. D. T.; Cron, N.; Vaid, N.; Emmanuel, J.; Siddiqui, S. S.; Prabu, N.; Chaudhari, H. K.; Patil, V. P.; Divatia, J. V.; Solanki, S.; Kulkarni, A. P.; Gutierrez, L. A. Rincon; Bader, A.; Brasseur, A.; Lheureux, O.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Hempel, D.; Stauffert, N.; Recker, F.; Schröder, T.; Reusch, S.; Schleifer, J.; Breitkreutz, R.; Sjövall, F.; Perner, A.; Møller, M. Hylander; Moraes, R. B.; Borges, F. K.; Guillen, J. A. V.; Zabaletta, W. J. C.; Ruiz-Ramos, J.; Ramirez, P.; Marqués-Miñana, M. R.; Villarreal, E.; Gordon, M.; Sosa, M.; Concha, P.; Castellanos, A.; Menendez, R.; Ramírez, C. Sánchez; Santana, M. Cabrera; Balcázar, L. Caipe; Escalada, S. Hípola; Viera, M. A. Hernández; Vázquez, C. F. Lübbe; Díaz, J. J. Díaz; Campelo, F. Artiles; Monroy, N. Sangil; Santana, P. Saavedra; Santana, S. Ruiz; Gutiérrez-Pizarraya, A.; Garnacho-Montero, J.; Martin, C.; Baumstarck, K.; Leone, M.; Martín-Loeches, I.; Pirracchio, R.; Legrand, M.; Mainardi, J. L.; Mantz, J.; Cholley, B.; Hubbard, A.; Frontera, P. Ruiz; Vega, L. M. Claraco; Miguelena, P. Ruiz de Gopegui; Usón, M. C. Villuendas; López, A. Rezusta; Clemente, E. Aurensanz; Ibañes, P. Gutiérrez; Aguilar, A. L. Ruiz; Palomar, M.; Olaechea, P.; Uriona, S.; Vallverdu, M.; Catalan, M.; Nuvials, X.; Aragon, C.; Lerma, F. Alvarez; Jeon, Y. D.; Jeong, W. Y.; Kim, M. H.; Jeong, I. Y.; Ahn, M. Y.; Ahn, J. Y.; Han, S. H.; Choi, J. Y.; Song, Y. G.; Kim, J. M.; Ku, N. S.; Bassi, G. Li; Xiol, E. Aguilera; Senussi, T.; Idone, F. A.; Motos, A.; Chiurazzi, C.; Travierso, C.; Fernández-Barat, L.; Amaro, R.; Hua, Y.; Ranzani, O. T.; Bobi, Q.; Rigol, M.; Torres, A.; Fernández, I. Fuentes; Soler, E. Andreu; de Vera, A. Pareja Rodríguez; Pastor, E. Escudero; Hernandis, V.; Ros Martínez, J.; Rubio, R. Jara; Torner, M. Miralbés; Brugger, S. Carvalho; Eroles, A. Aragones; Moles, S. Iglesias; Cabello, J. Trujillano; Schoenenberger, J. A.; Casals, X. Nuvials; Vidal, M. Vallverdu; Garrido, B. Balsera; Martinez, M. Palomar; Mirabella, L.; Cotoia, A.; Tullo, L.; Stella, A.; Di Bello, F.; Di Gregorio, A.; Dambrosio, M.; Cinnella, G.; Rosario, L. E. de la Cruz; Lesmes, S. P. Gómez; Romero, J. C. García; Herrera, A. N. García; Pertuz, E. D. Díaz; Sánchez, M. J. Gómez; Sanz, E. Regidor; Hualde, J. Barado; Hernández, A. Ansotegui; Ramirez, J. Roldán; Takahashi, H.; Kazutoshi, F.; Okada, Y.; Oobayashi, W.; Naito, T.; Baidya, D. K.; Maitra, S.; Anand, R. K.; Ray, B. R.; Arora, M. K.; Ruffini, C.; Rota, L.; Corona, A.; Sesana, G.; Ravasi, S.; Catena, E.; Naumann, D. N.; Mellis, C.; Husheer, S. L.; Bishop, J.; Midwinter, M. J.; Hutchings, S.; Corradi, F.; Brusasco, C.; Manca, T.; Ramelli, A.; Lattuada, M.; Nicolini, F.; Gherli, T.; Vezzani, A.; Young, A.; Carmona, A. Fernández; Santiago, A. Iglesias; Guillamon, L. Navarro; Delgado, M. J. García; Delgado-Amaya, M.; Curiel-Balsera, E.; Rivera-Romero, L.; Castillo-Lorente, E.; Carrero-Gómez, F.; Aguayo-DeHoyos, E.; Healey, A. J.; Cameron, C.; Jiao, L.R.; Stümpfle, R.; Pérez, A.; Martin, S.; del Moral, O. Lopez; Toval, S.; Rico, J.; Aldecoa, C.; Oguzhan, K.; Demirkiran, O.; Kirman, M.; Bozbay, S.; Kosuk, M. E.; Asyralyyeva, G.; Dilek, M.; Duzgun, M.; Telli, S.; Aydin, M.; Yilmazer, F.; Hodgson, L. E.; Dimitrov, B. D.; Stubbs, C.; Forni, L. G.; Venn, R.; Vedage, D.; Shawaf, S.; Naran, P.; Sirisena, N.; Kinnear, J.; Dimitrov, B. D.; Hodgson, L. E.; Stubbs, C.; Forni, L. G.; Venn, R.; Londoño, J. Gonzalez; Cardenas, C. Lorencio; Ginés, A. Sánchez; Gubianas, C. Murcia; Sánchez, E. Clapes; Sirvent, J. M.; Panafidina, V.; Shlyk, I.; Ilyina, V.; Judickas, S.; Kezyte, G.; Urbanaviciute, I.; Serpytis, M.; Gaizauskas, E.; Sipylaite, J.; Sprung, C. L.; Munteanu, G.; Morales, R. C.; Kasdan, H.; Volker, T.; Reiter, A.; Cohen, Y.; Himmel, Y.; Meissonnier, J.; Banderas-Bravo, M. E.; Gómez-Jiménez, C.; García-Martínez, M. V.; Martínez-Carmona, J. F.; Fernández-Ortega, J. F.; O‘Dwyer, M. J.; Starczewska, M.; Wilks, M.; Vincent, J. L.; Torsvik, M.; Gustad, L. T.; Bangstad, I. L.; Vinje, L. J.; Damås, J. K.; Solligård, E.; Mehl, A.; Tsunoda, M.; Kang, M.; Saito, M.; Saito, N.; Akizuki, N.; Namiki, M.; Takeda, M.; Yuzawa, J.; Yaguchi, A.; Frantzeskaki, F.; Tsirigotis, P.; Chondropoulos, S.; Paramythiotou, E.; Theodorakopoulou, M.; Stamouli, M.; Gkirkas, K.; Dimopoulou, I. K.; Makiko, S.; Tsunoda, M.; Kang, M.; Yuzawa, J.; Akiduki, N.; Namiki, M.; Takeda, M.; Yaguchi, A.; Preau, S.; Ambler, M.; Sigurta, A.; Saeed, S.; Singer, M.; Jochmans, S.; Chelly, J.; Vong, L. V. P.; Sy, O.; Serbource-Goguel, J.; Rolin, N.; Weyer, C. M.; Abdallah, R. I.; Adrie, C.; Vinsonneau, C.; Monchi, M.; Mayr, U.; Huber, W.; Karsten, E.; Lahmer, T.; Thies, P.; Henschel, B.; Fischer, G.; Schmid, R. M.; Ediboglu, O.; Ataman, S.; Naz, I.; Yaman, G.; Kirakli, C.; Su, P. L.; Kou, P. S.; Lin, W. C.; Chen, C. W.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Riad, Z.; Mezidi, M.; Aublanc, M.; Perinel, S.; Lissonde, F.; Louf-Durier, A.; Yonis, H.; Tapponnier, R.; Richard, J. C.; Louis, B.; Guérin, C.; Mezidi, M.; Yonis, H.; Aublanc, M.; Lissonde, F.; Louf-Durier, A.; Perinel, S.; Tapponnier, R.; Richard, J. C.; Guérin, C.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Loizou, C.; Soilemezi, E.; Matamis, D.; Somhorst, P.; Gommers, D.; Hayashi, K.; Hirayama, T.; Yumoto, T.; Tsukahara, K.; Iida, A.; Nosaka, N.; Sato, K.; Ugawa, T.; Nakao, A.; Ujike, Y.; Hirohata, S.; Mojoli, F.; Torriglia, F.; Giannantonio, M.; Orlando, A.; Bianzina, S.; Tavazzi, G.; Mongodi, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Jansen, D.; Gadgil, S.; Doorduin, J.; Roesthuis, L.; van der Hoeven, J. G.; Heunks, L. M. A.; Chen, G. Q.; Sun, X. M.; He, X.; Yang, Y. L.; Shi, Z. H.; Xu, M.; Zhou, J. X.; Pereira, S. M.; Tucci, M. R.; Tonelotto, B. F. F.; Simoes, C. M.; Morais, C. C. A.; Pompeo, M. S.; Kay, F. U.; Amato, M. B. P.; Vieira, J. E.; Suzuki, S.; Mihara, Y.; Hikasa, Y.; Okahara, S.; Morimatsu, H.; Kwon, H. M.; Moon, Y. J.; Lee, S. H.; Jung, K. W.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. S.; Lee, S.; Moon, Y. J.; Kwon, H. M.; Jung, K.; Shin, W. J.; Jun, I. G.; Song, J. G.; Hwang, G. S.; Ramelli, A.; Manca, T.; Corradi, F.; Brusasco, C.; Nicolini, F.; Gherli, T.; Brianti, R.; Fanzaghi, P.; Vezzani, A.; Tudor, B. A.; Klaus, D. A.; Lebherz-Eichinger, D.; Lechner, C.; Schwarz, C.; Bodingbauer, M.; Seemann, R.; Kaczirek, K.; Fleischmann, E.; Roth, G. A.; Krenn, C. G.; Malyshev, A.; Sergey, S.; Yamaguchi, Y.; Nomura, T.; Yoshitake, E.; Idei, M.; Yoshida, T.; Takaki, S.; Yamaguchi, O.; Kaneko, M.; Goto, T.; Tencé, N.; Zaien, I.; Wolf, M.; Trouiller, P.; Jacobs, F. M.; Kelly, J. M.; Veigas, P.; Hollands, S.; Min, A.; Rizoli, S.; Robles, C. M. Coronado; de Oca Sandoval, M. A. Montes; Tarabrin, O.; Gavrychenko, D.; Mazurenko, G.; Tarabrin, P.; Garcia, I. Palacios; Martin, A. Diaz; Mendez, M. Casado; orden, V. Arellano; Noval, R. Leal; McCue, C.; Gemmell, L.; MacKay, A.; Luján, J.; Villa, P.; Llorente, B.; Molina, R.; Alcázar, L.; Juanas, C. Arenillas; Rogero, S.; Pascual, T.; Cambronero, J. A.; Almudévar, P. Matía; Domínguez, J. Palamidessi; Carmona, S. Alcántara; Castañeda, D. Palacios; Abellán, A. Naharro; Lucendo, A. Pérez; Pérez, L. Pérez; Rivas, R. Fernández; Sanz, N. Martínez; Ramos, J. Veganzones; Villamizar, P. Rodríguez; Javadpour, S.; Kalani, N.; Amininejad, T.; Jamali, S.; Sobhanian, S.; Laurent, A.; Bonnet, M.; Rigal, R.; Aslanian, P.; Hebert, P.; Capellier, G.; Contreras, M. R. Diaz; Mejías, C. Rodriguez; Ruiz, F. C. Santiago; Lombardo, M. Duro; Perez, J. Castaño; de Hoyos, E. Aguayo; Estella, A.; Viciana, R.; Fontaiña, L. Perez; Rico, T.; Madueño, V. Perez; Recuerda, M.; Fernández, L.; Sandiumenge, A.; Bonet, S.; Mazo, C.; Rubiera, M.; Ruiz-Rodríguez, J. C.; Gracia, R. M.; Espinel, E.; Pont, T.; Kotsopoulos, A.; Jansen, N.; Abdo, W. F.; Gopcevic, A.; Gavranovic, Z.; Vucic, M.; Glogoski, M. Zlatic; Penavic, L. Videc; Horvat, A.; Martin-Villen, L.; Egea-Guerero, J. J.; Revuelto-Rey, J.; Aldabo-Pallas, T.; Correa-Chamorro, E.; Gallego-Corpa, A. I.; Granados, P. Ruiz del Portal-Ruiz; Faivre, V.; Wildenberg, L.; Huot, B.; Lukaszewicz, A. C.; Simsir, M.; Mengelle, C.; Payen, D.; Sanz, N. Martinez; Valbuena, B. Lobo; de la Fuente, M. Valdivia; Almudena, P. Matía; Pérez, L. Pérez; Carmona, S. Alcántara; Abellán, A. Navarro; Simón, I. Fernández; Muñoz, J. J. Rubio; Ramos, J. Veganzones; Carmona, S. Alcantara; Almudevar, P. Matia; Abellan, A. Naharro; Lucendo, M. A. Perez; Perez, L. Perez; Dominguez, J. Palamidessi; Rivas, R. Fernandez; Villamizar, P. Rodriguez; Wee, S.; Ong, C.; Lau, Y. H.; Wong, Y.; Banderas-Bravo, M. E.; Olea-Jiménez, V.; Mora-Ordóñez, J. M.; Gómez-Jiménez, C.; Muñoz-Muñoz, J. L.; Vallejo-Báez, J.; Daga-Ruiz, D.; Lebrón-Gallardo, M.; Rialp, G.; Raurich, J. M.; Morán, I.; Martín, M. C.; Heras, G.; Mas, A.; Vallverdú, I.; Hraiech, S.; Bourenne, J.; Guervilly, C.; Forel, J. M.; Adda, M.; Sylla, P.; Mouaci, A.; Gainnier, M.; Papazian, L.; Bauer, P. R.; Kumbamu, A.; Wilson, M. E.; Pannu, J. K.; Egginton, J. S.; Kashyap, R.; Gajic, O.; Yoshihiro, S.; Sakuraya, M.; Hayakawa, M.; Hirata, A.; Kawamura, N.; Tsutui, T.; Yoshida, K.; Hashimoto, Y.; Chang, C. H.; Hu, H. C.; Chiu, L. C.; Hung, C. Y.; Li, S. H.; Kao, K. C.; Sibley, S.; Drover, J.; D’Arsigny, C.; Parker, C.; Howes, D.; Moffatt, S.; Erb, J.; Ilan, R.; Messenger, D.; Ball, I.; Boyd, J. G.; Harrison, M.; Ridi, S.; Muscedere, J.; Andrade, A. H.; Costa, R. C.; Souza, V. A.; Gonzalez, V.; Amorim, V.; Rolla, F.; Filho, C. A. C. Abreu; Miranda, R.; Atchasiri, S.; Buranavanich, P.; Wathanawatthu, T.; Suwanpasu, S.; Bureau, C.; Rolland-Debord, C.; Poitou, T.; Clavel, M.; Perbet, S.; Terzi, N.; Kouatchet, A.; Similowski, T.; Demoule, A.; Diaz, P.; Nunes, J.; Escórcio, S.; Silva, G.; Chaves, S.; Jardim, M.; Câmara, M.; Fernandes, N.; Duarte, R.; Jardim, J. J.; Pereira, C. A.; Nóbrega, J. J.; Chen, C. M.; Lai, C. C.; Cheng, K. C.; Chou, W.; Lee, S. J.; Cha, Y. S.; Lee, W. Y.; Onodera, M.; Nakataki, E.; Oto, J.; Imanaka, H.; Nishimura, M.; Khadjibaev, A.; Sabirov, D.; Rosstalnaya, A.; Akalaev, R.; Parpibaev, F.; Antonucci, E.; Rossini, P.; Gandolfi, S.; Montini, E.; Orlando, S.; van Nes, M.; Karachi, F.; Hanekom, S.; Andrade, A. H.; Pereira, U. V.; Filho, C. A. C. Abreu; Costa, R. C.; Parkin, M. S. W.; Moore, M.; Andrade, A. H.; Costa, R. C.; Carvalho, K. V. Silva; Filho, C. A. C. Abreu; Min, H. J.; Kim, H. J.; Lee, D. S.; Choi, Y. Y.; Lee, E. Y.; Song, I.; Kim, D. J.; E, Y. Y.; Kim, J. W.; Park, J. S.; Cho, Y. J.; Lee, J. H.; Suh, J. W.; Jo, Y. H.; Kim, K. S.; Lee, Y. J.; Ferrero-Calleja, J.; Merino-Vega, D.; González-Jiménez, A. I.; Sigcha, M. Sigcha; Hernández-Tejedor, A.; Martin-Vivas, A.; Gabán-Díez, Á.; Luna, R. Ruiz-de; De la Calle-Pedrosa, N.; Temprano-Gómez, I.; Afonso-Rivero, D.; Pellin-Ariño, J. I.; Algora-Weber, A.; Fumis, R. R. L.; Ferraz, A. B.; Junior, J. M. Vieira; Kirca, H.; Cakin, O.; Unal, M.; Mutlu, H.; Ramazanoglu, A.; Cengiz, M.; Nicolini, E. A.; Pelisson, F. G. F.; Nunes, R. S.; da Silva, S. L.; Carreira, M. M.; Bellissimo-Rodrigues, F.; Ferez, M. A.; Basile-Filho, A.; Chao, H. C.; Chen, C. M.; Chen, L.; Hravnak, M.; Clermont, G.; Pinsky, M.; Dubrawski, A.; Varas, J. Luján; Montero, R. Molina; Sánchez-Elvira, L. Alcázar; Díaz, P. Villa; Delgado, C. Pintado; Ruiz, B. Llorente; Guerrero, A. Pardo; Galache, J. A. Cambronero; Sherif, H.; Hassanin, H.; El Hossainy, R.; Samy, W.; Ly, H.; David, H.; Burtin, P.; Charpentier, C.; Barral, M.; Courant, P.; Fournel, E.; Gaide-Chevronnay, L.; Durand, M.; Albaladejo, P.; Payen, J. F.; Chavanon, O.; Ortiz, A. Blandino; Pozzebon, S.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Fumagalli, F.; Scala, S.; Affatato, R.; De Maglie, M.; Zani, D.; Novelli, D.; Marra, C.; Luciani, A.; De Zani, D.; Luini, M.; Letizia, T.; Pravettoni, D.; Staszewsky, L.; Masson, S.; Belloli, A.; Di Giancamillo, M.; Scanziani, E.; Latini, R.; Ristagno, G.; Kye, Y. C.; Suh, G. J.; Kwon, W. Y.; Kim, K. S.; Yu, K. M.; Babini, G.; Ristagno, G.; Grassi, L.; Fumagalli, F.; Bendel, S.; De Maglie, M.; Affatato, R.; Masson, S.; Latini, R.; Scanziani, E.; Reinikainen, M.; Skrifvars, M.; Kappler, F.; Blobner, M.; Schaller, S. J.; Roasio, A.; Costanzo, E.; Cardellino, S.; Iesu, E.; Cavicchi, F. Zama; Fontana, V.; Nobile, L.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Park, M.; You, K. M.; Suh, G. J.; Kwon, W. Y.; Ko, S. B.; Kim, K. S.; Xini, A.; Marca, L.; Lheureux, O.; Brasseur, A.; Vincent, J. L.; Creteur, J.; Taccone, F. S.; Beane, A.; Thilakasiri, M. C. K. T.; De Silva, A. P.; Stephens, T.; Sigera, C. S.; Athapattu, P.; Jayasinghe, S.; Padeniya, A.; Haniffa, R.; Santiago, A. Iglesias; Sáez, V. Chica; Ruiz-Ruano, R. de la Chica; González, A. Sánchez; Kunze-Szikszay, N.; Wand, S.; Klapsing, P.; Wetz, A.; Heyne, T.; Schwerdtfeger, K.; Troeltzsch, M.; Bauer, M.; Quintel, M.; Moerer, O.; Cook, D. J.; Rutherford, W. B.; Scales, D. C.; Adhikari, N. K.; Cuthbertson, B. H.; Suzuki, T.; Takei, T.; Fushimi, K.; Iwamoto, M.; Nakagawa, S.; Mendsaikhan, N.; Begzjav, T.; Lundeg, G.; Dünser, M. W.; Romero, D. González; Cabrera, J. L. Santana; Santana, J. D. Martín; Padilla, Y. Santana; Pérez, H. Rodríguez; Torrent, R. Lorenzo; Kleinpell, R.; Chouris, I.; Radu, V.; Stougianni, M.; Lavrentieva, A.; Lagonidis, D.; Price, R. D. T.; Day, A.; Arora, N.; Henderson, M. A.; Hickey, S.; Costa, M. I. Almeida; Carvalho, J. P.; Gomes, A. A.; Mergulhão, P. J.; Chan, K. K. C.; Shum, H. P.; Yan, W. W.; Maghsoudi, B.; Tabei, S. H.; Masjedi, M.; Sabetian, G.; Tabatabaei, H. R.; Akbarzadeh, A.; Saigal, S.; Pakhare, A.; Joshi, R.; Pattnaik, S. K.; Ray, B.; Rousseau, A. F.; Michel, L.; Bawin, M.; Cavalier, E.; Reginster, J. Y.; Damas, P.; Bruyere, O.; Zhou, J. C.; Cauwenberghs, H.; De Backer, A.; Neels, H.; Deblier, I.; Berghmans, J.; Himpe, D.; Barea-Mendoza, J. A.; Portillo, I. Prieto; Fernández, M. Valiente; Gigorro, R. Garcia; Vela, J. L. Perez; Mateos, H. Marín; Alves, S. Chacón; Varas, G. Morales; Rodriguez-Biendicho, A.; Carreño, E. Renes; González, J. C. Montejo; Yang, J. S.; Chiang, C. H.; Hung, W. T.; Huang, W. C.; Cheng, C. C.; Lin, K. C.; Lin, S. C.; Chiou, K. R.; Wann, S. R.; Lin, K. L.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Zhou, J. C.; Choi, Y. J.; Yoon, S. Z.; Gordillo-Brenes, A.; Fernandez-Zamora, M. D.; Perez-Borrero, L.; Arias-Verdu, M. D.; Aguilar-Alonso, E.; Herruzo-Aviles, A.; Garcia-Delgado, M.; Hinojosa-Perez, R.; Curiel-Balsera, E.; Rivera-Fernandez, R.; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Herrera, A. N. García; Sanz, E. Regidor; Sánchez, M. J. Gómez; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Irazabal, J. M. Guergue; Pérez, A. González; Fernández, P. Alvarez; Amor, L. Lopéz; Albaiceta, G. Muñiz; Lesmes, S. P. Gómez; Rosario, L. E. De la Cruz; Hernández, A. Ansotegui; Sanz, E. Regidor; Sánchez, M. J. Gómez; Calvo, S. Aldunate; Herrera, A. N. García; Hualde, J. Barado; Pascual, O. Agudo; León, J. P. Tirapu; Corona, A.; Ruffini, C.; Spazzadeschi, A.; Marrazzo, F.; Gandola, A.; Sciurti, R.; Savi, C.; Catena, E.; Ke, M. W.; Cheng, C. C.; Huang, W. C.; Chiang, C. H.; Hung, W. T.; Lin, K. C.; Lin, S. C.; Wann, S. R.; Chiou, K. R.; Tseng, C. J.; Kang, P. L.; Mar, G. Y.; Liu, C. P.; Bertini, P.; De Sanctis, F.; Guarracino, F.; Bertini, P.; Baldassarri, R.; Guarracino, F.; Buitinck, S. H.; van der Voort, P. H. J.; Oto, J.; Nakataki, E.; Tsunano, Y.; Izawa, M.; Tane, N.; Onodera, M.; Nishimura, M.; Ghosh, S.; Gupta, A.; De Gasperi, A.; Mazza, E.; Limuti, R.; Prosperi, M.; Bissenova, N.; Yergaliyeva, A.; Talan, L.; Yılmaz, G.; Güven, G.; Yoruk, F.; Altıntas, N. D.; Mukherjee, D. N.; Agarwal, L. K.; Mandal, K.; Palomar, M.; Balsera, B.; Vallverdu, M.; Martinez, M.; Garcia, M.; Castellana, D.; Lopez, R.; Barcenilla, F.; Kaminsky, G. E.; Carreño, R.; Escribá, A.; Fuentes, M.; Gálvez, V.; Del Olmo, R.; Nieto, B.; Vaquerizo, C.; Alvarez, J.; De la Torre, M. A.; Torres, E.; Bogossian, E.; Nouer, S. Aranha; Salgado, D. Ribeiro; Brugger, S. Carvalho; Jiménez, G. Jiménez; Torner, M. Miralbés; Vidal, M. Vallverdú; Garrido, B. Balsera; Casals, X. Nuvials; Gaite, F. Barcenilla; Cabello, J. Trujillano; Martínez, M. Palomar; Doganci, M.; Izdes, S.; Besevli, S. Guzeldag; Alkan, A.; Kayaaslan, B.; Ramírez, C. Sánchez; Balcázar, L. Caipe; Santana, M. Cabrera; Viera, M. A. Hernández; Escalada, S. Hípola; Vázquez, C. F. Lübbe; Penichet, S. M. Marrero; Campelo, F. Artiles; López, M. A. De La Cal; Santana, P. Saavedra; Santana, S. Ruíz; Repessé, X.; Artiguenave, M.; Paktoris-Papine, S.; Espinasse, F.; Dinh, A.; El Sayed, F.; Charron, C.; Géri, G.; Vieillard-Baron, A.; Marmanidou, K.; Oikonomou, M.; Nouris, C.; Dimitroulakis, K.; Soilemezi, E.; Matamis, D.; Ferré, A.; Guillot, M.; Teboul, J. L.; Lichtenstein, D.; Mézière, G.; Richard, C.; Monnet, X.; Pham, T.; Beduneau, G.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Prīdāne, S.; Sabeļņikovs, O.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Beduneau, G.; Pham, T.; Schortgen, F.; Piquilloud, L.; Zogheib, E.; Jonas, M.; Grelon, F.; Runge, I.; Terzi, N.; Grangé, S.; Barberet, G.; Guitard, P. G.; Frat, J. P.; Constan, A.; Chrétien, J. M.; Mancebo, J.; Mercat, A.; Richard, J. C. M.; Brochard, L.; Kondili, E.; Psarologakis, C.; Kokkini, S.; Amargianitakis, V.; Babalis, D.; Chytas, A.; Chouvarda, I.; Vaporidi, K.; Georgopoulos, D.; Trapp, O.; Kalenka, A.; Mojoli, F.; Orlando, A.; Bianchi, I.; Torriglia, F.; Bianzina, S.; Pozzi, M.; Iotti, G. A.; Braschi, A.; Lozano, J. A. Benítez; Sánchez, P. Carmona; Francioni, J. E. Barrueco; Ferrón, F. Ruiz; Simón, J. M. Serrano; Spadaro, S.; Karbing, D. S.; Gioia, A.; Moro, F.; Corte, F. Dalla; Mauri, T.; Volta, C. A.; Rees, S. E.; Petrova, M. V.; Mohan, R.; Butrov, A. V.; Beeharry, S. D.; Vatsik, M. V.; Sakieva, F. I.; Gobert, F.; Yonis, H.; Tapponnier, R.; Fernandez, R.; Labaune, M. A.; Burle, J. F.; Barbier, J.; Vincent, B.; Cleyet, M.; Richard, J. C.; Guérin, C.; Shinotsuka, C. Righy; Creteur, J.; Taccone, F. S.; Törnblom, S.; Nisula, S.; Vaara, S.; Poukkanen, M.; Andersson, S.; Pettilä, V.; Pesonen, E.; Xie, Z.; Liao, X.; Kang, Y.; Zhang, J.; Kubota, K.; Egi, M.; Mizobuchi, S.; Hegazy, S.; El-Keraie, A.; El Sayed, E.; El Hamid, M. Abd; Rodrigues, N. J.; Pereira, M.; Godinho, I.; Gameiro, J.; Neves, M.; Gouveia, J.; e Silva, Z. Costa; Lopes, J. A.; Mckinlay, J.; Kostalas, M.; Kooner, G.; Dudas, G.; Horton, A.; Kerr, C.; Karanjia, N.; Creagh-Brown, B.; Forni, L.; Yamazaki, A.; Ganuza, M. Sanz; Molina, J. A. Martinez; Martinez, F. Hidalgo; Freile, M. T. Chiquito; Fernandez, N. Garcia; Travieso, P. Medrano; Bandert, A.; Frithiof, R.; Lipcsey, M.; Smekal, D.; Schlaepfer, P.; Durovray, J. D.; Plouhinec, V.; Chiappa, C.; Bellomo, R.; Schneider, A. G.; Mitchell, S.; Durrant, J.; Street, H.; Dunthorne, E.; Shears, J.; Caballero, C. Hernandez; Hutchison, R.; Schwarze, S.; Ghabina, S.; Thompson, E.; Prowle, J. R.; Kirwan, C. J.; Gonzalez, C. A.; Pinto, J. L.; Orozco, V.; Patiño, J. A.; Garcia, P. K.; Contreras, K. M.; Rodriguez, P.; Echeverri, J. E. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 journal: Intensive Care Med Exp DOI: 10.1186/s40635-016-0100-7 sha: doc_id: 14533 cord_uid: 6qfecv5h file: cache/cord-005497-w81ysjf9.json key: cord-005497-w81ysjf9 authors: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 journal: Crit Care DOI: 10.1186/s13054-020-2772-3 sha: doc_id: 5497 cord_uid: w81ysjf9 file: cache/cord-005105-twsy61oq.json key: cord-005105-twsy61oq authors: nan title: SIU 2015 Abstracts date: 2015-09-21 journal: World J Urol DOI: 10.1007/s00345-015-1684-3 sha: doc_id: 5105 cord_uid: twsy61oq file: cache/cord-005727-li8pwigg.json key: cord-005727-li8pwigg authors: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-1999-x sha: doc_id: 5727 cord_uid: li8pwigg file: cache/cord-022879-j6cecioe.json key: cord-022879-j6cecioe authors: Fager, Edward W. title: Determination and Analysis of Recurrent Groups date: 1957-10-01 journal: Ecology DOI: 10.2307/1943124 sha: doc_id: 22879 cord_uid: j6cecioe file: cache/cord-015024-2xzc0uc5.json key: cord-015024-2xzc0uc5 authors: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 journal: Intensive Care Med DOI: 10.1007/s00134-010-2001-7 sha: doc_id: 15024 cord_uid: 2xzc0uc5 file: cache/cord-016842-sow7k53m.json key: cord-016842-sow7k53m authors: An, Jisun; Kwak, Haewoon title: Multidimensional Analysis of the News Consumption of Different Demographic Groups on a Nationwide Scale date: 2017-08-02 journal: Social Informatics DOI: 10.1007/978-3-319-67217-5_9 sha: doc_id: 16842 cord_uid: sow7k53m file: cache/cord-015372-76xvzvdg.json key: cord-015372-76xvzvdg authors: nan title: National scientific medical meeting 1996 abstracts date: 1996 journal: Ir J Med Sci DOI: 10.1007/bf02945204 sha: doc_id: 15372 cord_uid: 76xvzvdg file: cache/cord-006854-o2e5na78.json key: cord-006854-o2e5na78 authors: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 journal: Surg Endosc DOI: 10.1007/s00464-018-6121-4 sha: doc_id: 6854 cord_uid: o2e5na78 file: cache/cord-010980-sizuef1v.json key: cord-010980-sizuef1v authors: nan title: ECTES Abstracts 2020 date: 2020-05-11 journal: Eur J Trauma Emerg Surg DOI: 10.1007/s00068-020-01343-y sha: doc_id: 10980 cord_uid: sizuef1v file: cache/cord-014464-m5n250r2.json key: cord-014464-m5n250r2 authors: Sole-Violan, J; Sologuren, I; Betancor, E; Zhang, S; Pérez, C; Herrera-Ramos, E; Martínez-Saavedra, M; López-Rodríguez, M; Pestano, J; Ruiz-Hernández, J; Ferrer, J; Rodríguez de Castro, F; Casanova, J; Rodríguez-Gallego, C title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 journal: Crit Care DOI: 10.1186/cc11953 sha: doc_id: 14464 cord_uid: m5n250r2 file: cache/cord-014527-nvzfpntu.json key: cord-014527-nvzfpntu authors: nan title: Research Communications of the 25th ECVIM‐CA Congress date: 2015-11-09 journal: J Vet Intern Med DOI: 10.1111/jvim.13647 sha: doc_id: 14527 cord_uid: nvzfpntu file: cache/cord-022643-2j559muh.json key: cord-022643-2j559muh authors: Chance, Gail D.; Bacon, John D. title: SYSTEMATIC IMPLICATIONS OF SEED COAT MORPHOLOGY IN NAMA (HYDROPHYLLACEAE) date: 1984-07-01 journal: Am J Bot DOI: 10.1002/j.1537-2197.1984.tb14148.x sha: doc_id: 22643 cord_uid: 2j559muh file: cache/cord-022973-soaz8b74.json key: cord-022973-soaz8b74 authors: Trivellini, Guido; Polidori, Carlo; Pasquaretta, Cristian; Orsenigo, Simone; Bogliani, Giuseppe title: Nestedness of habitat specialists within habitat generalists in a butterfly assemblage date: 2016-09-25 journal: Insect Conserv Divers DOI: 10.1111/icad.12193 sha: doc_id: 22973 cord_uid: soaz8b74 file: cache/cord-000083-3p81yr4n.json key: cord-000083-3p81yr4n authors: nan title: Poster Exhibition date: 2009-01-31 journal: Hepatol Int DOI: 10.1007/s12072-009-9123-4 sha: doc_id: 83 cord_uid: 3p81yr4n file: cache/cord-026983-36n7bm3j.json key: cord-026983-36n7bm3j authors: Gillani, Syeda Shaista; Munawar, Munawar Ali; Khan, Khalid Mohammed; Chaudhary, Jamil Anwar title: Synthesis, characterization and applications of poly-aliphatic amine dendrimers and dendrons date: 2020-06-17 journal: J IRAN CHEM SOC DOI: 10.1007/s13738-020-01973-4 sha: doc_id: 26983 cord_uid: 36n7bm3j file: cache/cord-006849-vgjz74ts.json key: cord-006849-vgjz74ts authors: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 journal: Surg Endosc DOI: 10.1007/s00464-019-07109-x sha: doc_id: 6849 cord_uid: vgjz74ts file: cache/cord-021419-nypnib0h.json key: cord-021419-nypnib0h authors: Olsufyeva, Evgenia N.; Yankovskaya, Valentina S. title: Main trends in the design of semi-synthetic antibiotics of a new generation date: 2020-03-17 journal: nan DOI: 10.1070/rcr4892 sha: doc_id: 21419 cord_uid: nypnib0h file: cache/cord-022281-xn0cf33a.json key: cord-022281-xn0cf33a authors: Tanz, Robert R.; Shulman, Stanford T. title: Sore Throat date: 2009-05-15 journal: Practical Strategies in Pediatric Diagnosis and Therapy DOI: 10.1016/b978-0-7216-9131-2.50005-1 sha: doc_id: 22281 cord_uid: xn0cf33a file: cache/cord-024461-xo75855r.json key: cord-024461-xo75855r authors: Zhang, Yuanzhe; Luo, Ling; Wang, Yang; Wang, Zhiyong title: FCP Filter: A Dynamic Clustering-Prediction Framework for Customer Behavior date: 2020-04-17 journal: Advances in Knowledge Discovery and Data Mining DOI: 10.1007/978-3-030-47426-3_45 sha: doc_id: 24461 cord_uid: xo75855r file: cache/cord-032657-1egdwe26.json key: cord-032657-1egdwe26 authors: Gouda, Walaa; Yasin, Rabab title: COVID-19 disease: CT Pneumonia Analysis prototype by using artificial intelligence, predicting the disease severity date: 2020-09-25 journal: Egypt J Radiol Nucl Med DOI: 10.1186/s43055-020-00309-9 sha: doc_id: 32657 cord_uid: 1egdwe26 file: cache/cord-023186-gqltd6u0.json key: cord-023186-gqltd6u0 authors: nan title: Poster Sessions date: 2019-06-27 journal: Pediatr Pulmonol DOI: 10.1002/ppul.24373 sha: doc_id: 23186 cord_uid: gqltd6u0 file: cache/cord-023225-5quigar4.json key: cord-023225-5quigar4 authors: nan title: Posters date: 2012-08-21 journal: J Pept Sci DOI: 10.1002/psc.2449 sha: doc_id: 23225 cord_uid: 5quigar4 file: cache/cord-032410-g546hez9.json key: cord-032410-g546hez9 authors: Hu, Yuan; Liu, Xu; Zhang, Tianyi; Chen, Chao; Dong, Xianzhe; Can, Yan; Liu, Ping title: Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depression date: 2020-08-27 journal: Front Pharmacol DOI: 10.3389/fphar.2020.561817 sha: doc_id: 32410 cord_uid: g546hez9 file: cache/cord-015368-a0qz4tb9.json key: cord-015368-a0qz4tb9 authors: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 journal: Eur Surg DOI: 10.1007/s10353-007-0330-8 sha: doc_id: 15368 cord_uid: a0qz4tb9 file: cache/cord-026493-z2hthkgy.json key: cord-026493-z2hthkgy authors: Newsom, Megan; Bashyam, Arjun M.; Balogh, Esther A.; Feldman, Steven R.; Strowd, Lindsay C. title: New and Emerging Systemic Treatments for Atopic Dermatitis date: 2020-06-09 journal: Drugs DOI: 10.1007/s40265-020-01335-7 sha: doc_id: 26493 cord_uid: z2hthkgy file: cache/cord-023311-7wqdlha4.json key: cord-023311-7wqdlha4 authors: nan title: Oral Session date: 2010-11-24 journal: Respirology DOI: 10.1111/j.1440-1843.2010.01864.x sha: doc_id: 23311 cord_uid: 7wqdlha4 file: cache/cord-024698-jrnw1i07.json key: cord-024698-jrnw1i07 authors: Hogan, Kevin; Shan, Fei; Ravichandran, Monikka; Bagmar, Aadesh; Wang, James; Sarsony, Adam; Purtilo, James title: Decidio: A Pilot Implementation and User Study of a Novel Decision-Support System date: 2020-04-25 journal: Group Decision and Negotiation: A Multidisciplinary Perspective DOI: 10.1007/978-3-030-48641-9_14 sha: doc_id: 24698 cord_uid: jrnw1i07 file: cache/cord-023134-y665agnh.json key: cord-023134-y665agnh authors: nan title: Oral Research Communications of the 22(nd) ECVIM‐CA Congress date: 2012-11-20 journal: J Vet Intern Med DOI: 10.1111/jvim.12000 sha: doc_id: 23134 cord_uid: y665agnh file: cache/cord-030277-x9zvx3fp.json key: cord-030277-x9zvx3fp authors: Ohta, Yoshinori; Miyamoto, Kyohei; Kawazoe, Yu; Yamamura, Hitoshi; Morimoto, Takeshi title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial date: 2020-08-10 journal: Crit Care DOI: 10.1186/s13054-020-03207-8 sha: doc_id: 30277 cord_uid: x9zvx3fp file: cache/cord-023017-k6edtg58.json key: cord-023017-k6edtg58 authors: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 journal: Hepatology DOI: 10.1002/hep.1840380505 sha: doc_id: 23017 cord_uid: k6edtg58 file: cache/cord-048469-xa9a5p0q.json key: cord-048469-xa9a5p0q authors: Klune, John R; Dhupar, Rajeev; Cardinal, Jon; Billiar, Timothy R; Tsung, Allan title: HMGB1: Endogenous Danger Signaling date: 2008-04-11 journal: Mol Med DOI: 10.2119/2008-00034.klune sha: doc_id: 48469 cord_uid: xa9a5p0q file: cache/cord-015306-us58wwmp.json key: cord-015306-us58wwmp authors: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 journal: Pediatr Nephrol DOI: 10.1007/s00467-013-2518-4 sha: doc_id: 15306 cord_uid: us58wwmp file: cache/cord-022653-qa1uph35.json key: cord-022653-qa1uph35 authors: nan title: Poster Discussion Session PDS date: 2017-08-30 journal: Allergy DOI: 10.1111/all.13251 sha: doc_id: 22653 cord_uid: qa1uph35 file: cache/cord-034714-6e37yylk.json key: cord-034714-6e37yylk authors: Alleg, Manel; Solis, Morgane; Baloglu, Seyyid; Cotton, François; Kerschen, Philippe; Bourre, Bertrand; Ahle, Guido; Pruvo, Jean-Pierre; Leclerc, Xavier; Vermersch, Patrick; Papeix, Caroline; Maillart, Élisabeth; Houillier, Caroline; Chabrot, Cécile Moluçon; Claise, Béatrice; Malak, Sandra; Martin-Blondel, Guillaume; Bonneville, Fabrice; Caulier, Alexis; Marolleau, Jean-Pierre; Bonnefoy, Jérôme Tamburini; Agape, Philippe; Kennel, Céline; Roussel, Xavier; Chauchet, Adrien; De Seze, Jérôme; Fafi-Kremer, Samira; Kremer, Stéphane title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML date: 2020-11-06 journal: Eur Radiol DOI: 10.1007/s00330-020-07362-y sha: doc_id: 34714 cord_uid: 6e37yylk file: cache/cord-035024-kx9jfssi.json key: cord-035024-kx9jfssi authors: Elmelhat, Ahmed; Elbourai, Essam; Dewedar, Hany; Elgergawi, Taghrid; Alkhanbouli, Maryam; Ahmed, Salwa; Malik, Zoiya; Nugud, Alaa; Mohammed, Shadha; Mohammad, Hozaifah; Husain, Abdullah title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 journal: nan DOI: 10.1159/000511163 sha: doc_id: 35024 cord_uid: kx9jfssi file: cache/cord-209697-bfc4h4b3.json key: cord-209697-bfc4h4b3 authors: Shanthakumar, Swaroop Gowdra; Seetharam, Anand; Ramesh, Arti title: Analyzing Societal Impact of COVID-19: A Study During the Early Days of the Pandemic date: 2020-10-27 journal: nan DOI: nan sha: doc_id: 209697 cord_uid: bfc4h4b3 file: cache/cord-193497-qqrhvlm5.json key: cord-193497-qqrhvlm5 authors: Shoghri, Ahmad El; Liebig, Jessica; Jurdak, Raja; Gardner, Lauren; Science, Salil S. Kanhere School of Computer; Engineering,; Wales, University of New South; Sydney,; Australia,; Data61,; Scientific, Commonwealth; Organization, Industrial Research; Brisbane,; Science, School of Computer; Technology, Queensland University of; Civil, Department of; Engineering, Systems; University, Johns Hopkins; Baltimore,; USA,; Innovation, Research Center for Integrated Transport; Sydney, UNSW title: Identifying highly influential travellers for spreading disease on a public transport system date: 2020-04-03 journal: nan DOI: nan sha: doc_id: 193497 cord_uid: qqrhvlm5 file: cache/cord-032979-jle66lmn.json key: cord-032979-jle66lmn authors: ROMMEREIM, D. N.; ROMMEREIM, R. L.; SIKOV, M. R.; BUSCHBOM, R. L.; ANDERSON, L. E. title: Reproduction, Growth, and Development of Rats during Chronic Exposure to Multiple Field Strengths of 60-Hz Electric Fields date: 1990-04-17 journal: Fundam Appl Toxicol DOI: 10.1093/toxsci/14.3.608 sha: doc_id: 32979 cord_uid: jle66lmn file: cache/cord-000977-ka4261wc.json key: cord-000977-ka4261wc authors: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 journal: Insights Imaging DOI: 10.1007/s13244-013-0228-x sha: doc_id: 977 cord_uid: ka4261wc file: cache/cord-234996-hah19vmk.json key: cord-234996-hah19vmk authors: Kabiri, Aliakbar; Darzi, Aref; Zhou, Weiyi; Sun, Qianqian; Zhang, Lei title: How different age groups responded to the COVID-19 pandemic in terms of mobility behaviors: a case study of the United States date: 2020-07-20 journal: nan DOI: nan sha: doc_id: 234996 cord_uid: hah19vmk file: cache/cord-253308-wgseqk4t.json key: cord-253308-wgseqk4t authors: Liu, Chang; Liu, Yunchao; Feng, Hua; Zhao, Baolei; Chen, Yumei; Huang, Huimin; Wang, Pan; Deng, Ruiguang; Zhang, Gaiping title: PCV cap proteins fused with calreticulin expressed into polymers in Escherichia coli with high immunogenicity in mice date: 2020-08-27 journal: BMC Vet Res DOI: 10.1186/s12917-020-02527-9 sha: doc_id: 253308 cord_uid: wgseqk4t file: cache/cord-103538-vh6ma7k7.json key: cord-103538-vh6ma7k7 authors: Smaldino, Paul E.; Jones, James Holland title: Coupled Dynamics of Behavior and Disease Contagion Among Antagonistic Groups date: 2020-10-05 journal: bioRxiv DOI: 10.1101/2020.06.17.157511 sha: doc_id: 103538 cord_uid: vh6ma7k7 file: cache/cord-259128-s27086aj.json key: cord-259128-s27086aj authors: Solano, Gloria I.; Segalés, Joaquim; Collins, James E.; Molitor, Thomas W.; Pijoan, Carlos title: Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with Haemophilus parasuis date: 1997-04-30 journal: Veterinary Microbiology DOI: 10.1016/s0378-1135(96)01325-9 sha: doc_id: 259128 cord_uid: s27086aj file: cache/cord-259996-uhrhsrky.json key: cord-259996-uhrhsrky authors: Lee, Seul Bee; Choi, Han Seul; Son, Sejung; Hong, Young Mi title: Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms date: 2015-07-16 journal: Korean Circ J DOI: 10.4070/kcj.2015.45.4.317 sha: doc_id: 259996 cord_uid: uhrhsrky file: cache/cord-014794-yppi30a0.json key: cord-014794-yppi30a0 authors: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 journal: Virchows Arch DOI: 10.1007/s00428-003-0864-5 sha: doc_id: 14794 cord_uid: yppi30a0 file: cache/cord-261163-n9tp9nx7.json key: cord-261163-n9tp9nx7 authors: Ko, Jae-Hoon; Müller, Marcel A.; Seok, Hyeri; Park, Ga Eun; Lee, Ji Yeon; Cho, Sun Young; Ha, Young Eun; Baek, Jin Yang; Kim, So Hyun; Kang, Ji-Man; Kim, Yae-Jean; Jo, Ik Joon; Chung, Chi Ryang; Hahn, Myong-Joon; Drosten, Christian; Kang, Cheol-In; Chung, Doo Ryeon; Song, Jae-Hoon; Kang, Eun-Suk; Peck, Kyong Ran title: Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity date: 2017-10-31 journal: Diagnostic Microbiology and Infectious Disease DOI: 10.1016/j.diagmicrobio.2017.07.006 sha: doc_id: 261163 cord_uid: n9tp9nx7 file: cache/cord-266597-v5glur2c.json key: cord-266597-v5glur2c authors: Sheng, Hui H; Zhang, Ge G; Cheung, Wing Hoi WH; Chan, Chun Wai CW; Wang, Yi Xiang YX; Lee, Kwong Man KM; Wang, Hong Fu HF; Leung, Kwok Sui KS; Qin, Ling L title: Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development date: 2007-10-15 journal: J Orthop Surg DOI: 10.1186/1749-799x-2-15 sha: doc_id: 266597 cord_uid: v5glur2c file: cache/cord-009567-osstpum6.json key: cord-009567-osstpum6 authors: nan title: Abstracts Oral date: 2008-04-23 journal: Am J Transplant DOI: 10.1111/j.1600-6143.2008.02254.x sha: doc_id: 9567 cord_uid: osstpum6 file: cache/cord-256165-cc3ph5e5.json key: cord-256165-cc3ph5e5 authors: Cree-Green, Melanie; Carreau, Anne-Marie; Davis, Shanlee M; Frohnert, Brigitte I; Kaar, Jill L; Ma, Nina S; Nokoff, Natalie J; Reusch, Jane E B; Simon, Stacey L; Nadeau, Kristen J title: Peer mentoring for professional and personal growth in academic medicine date: 2020-07-07 journal: J Investig Med DOI: 10.1136/jim-2020-001391 sha: doc_id: 256165 cord_uid: cc3ph5e5 file: cache/cord-264607-5vnaifi6.json key: cord-264607-5vnaifi6 authors: Chen, Wenyu; Yao, Ming; Fang, Zhixian; Lv, Xiaodong; Deng, Min; Wu, Zhen title: A study on clinical effect of Arbidol combined with adjuvant therapy on COVID‐19 date: 2020-06-08 journal: J Med Virol DOI: 10.1002/jmv.26142 sha: doc_id: 264607 cord_uid: 5vnaifi6 file: cache/cord-103779-qobzttqa.json key: cord-103779-qobzttqa authors: Rachwal, S.; Katritzky, A. R. title: 5.01 1,2,3-Triazoles date: 2008-12-31 journal: nan DOI: 10.1016/b978-008044992-0.00501-0 sha: doc_id: 103779 cord_uid: qobzttqa file: cache/cord-239632-dyvhzvmm.json key: cord-239632-dyvhzvmm authors: McGuigan, Michael title: Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning date: 2020-08-03 journal: nan DOI: nan sha: doc_id: 239632 cord_uid: dyvhzvmm file: cache/cord-261073-s0qpiovr.json key: cord-261073-s0qpiovr authors: Ehrengut, W.; Sarateanu, D. E. title: A two year serological surveillance of coronavirus infections in Hamburg date: 1980 journal: Infection DOI: 10.1007/bf01639150 sha: doc_id: 261073 cord_uid: s0qpiovr file: cache/cord-262716-hea84shy.json key: cord-262716-hea84shy authors: Pourali, Fatemeh; Afshari, Mahdi; Alizadeh-Navaei, Reza; Javidnia, Javad; Moosazadeh, Mahmood; Hessami, Amirhossein title: Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis date: 2020-08-11 journal: New Microbes New Infect DOI: 10.1016/j.nmni.2020.100743 sha: doc_id: 262716 cord_uid: hea84shy file: cache/cord-260272-645g3to1.json key: cord-260272-645g3to1 authors: Haddad, Kevin; Potter, Brian J.; Matteau, Alexis; Gobeil, François; Mansour, Samer title: COVID-19 implications on STEMI care date: 2020-09-19 journal: Cardiovasc Revasc Med DOI: 10.1016/j.carrev.2020.09.024 sha: doc_id: 260272 cord_uid: 645g3to1 file: cache/cord-270727-2dd3b7di.json key: cord-270727-2dd3b7di authors: Rivera-Benitez, José Francisco; De la Luz-Armendáriz, Jazmín; Saavedra-Montañez, Manuel; Jasso-Escutia, Miguel Ángel; Sánchez-Betancourt, Ivan; Pérez-Torres, Armando; Reyes-Leyva, Julio; Hernández, Jesús; Martínez-Lara, Atalo; Ramírez-Mendoza, Humberto title: Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus date: 2016-02-29 journal: Vet Microbiol DOI: 10.1016/j.vetmic.2016.01.005 sha: doc_id: 270727 cord_uid: 2dd3b7di file: cache/cord-266722-qfn2dc1q.json key: cord-266722-qfn2dc1q authors: Wormser, Gary P.; Nunez, Miguel; Horn, David title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 journal: Clinics in Dermatology DOI: 10.1016/0738-081x(87)90013-7 sha: doc_id: 266722 cord_uid: qfn2dc1q file: cache/cord-270210-gfy2ytg5.json key: cord-270210-gfy2ytg5 authors: Drent, Marjolein; Elfferich, Marjon; Breedveld, Ellen; Vries, Jolanda De; Strookappe, Bert title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 journal: J Pers Med DOI: 10.3390/jpm10030097 sha: doc_id: 270210 cord_uid: gfy2ytg5 file: cache/cord-274396-l611eisi.json key: cord-274396-l611eisi authors: Park, Su-Jin; Yu, Kwang-Min; Kim, Young-Il; Kim, Se-Mi; Kim, Eun-Ha; Kim, Seong-Gyu; Kim, Eun Ji; Casel, Mark Anthony B.; Rollon, Rare; Jang, Seung-Gyu; Lee, Min-Hyeok; Chang, Jae-Hyung; Song, Min-Suk; Jeong, Hye Won; Choi, Younho; Chen, Weiqiang; Shin, Woo-Jin; Jung, Jae U.; Choi, Young Ki title: Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets date: 2020-05-22 journal: mBio DOI: 10.1128/mbio.01114-20 sha: doc_id: 274396 cord_uid: l611eisi file: cache/cord-261380-xms5su6w.json key: cord-261380-xms5su6w authors: Rahmani, Hamid; Davoudi-Monfared, Effat; Nourian, Anahid; Khalili, Hossein; Hajizadeh, Nooshin; zarei Jalalabadi, Narjes; Reza Fazeli, Mohammad; Ghazaeian, Monireh; Saeed Yekaninejad, Mir title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 journal: Int Immunopharmacol DOI: 10.1016/j.intimp.2020.106903 sha: doc_id: 261380 cord_uid: xms5su6w file: cache/cord-271106-srym2kh4.json key: cord-271106-srym2kh4 authors: De Rosa, Nicoletta; Giampaolino, Pierluigi; Lavitola, Giada; Morra, Ilaria; Formisano, Carmen; Nappi, Carmine; Bifulco, Giuseppe title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study date: 2019-04-11 journal: Biomed Res Int DOI: 10.1155/2019/3548396 sha: doc_id: 271106 cord_uid: srym2kh4 file: cache/cord-270998-1adloi3o.json key: cord-270998-1adloi3o authors: Cunha, Rafes D. S.; da Silva Junior, Camilo L.; Costa, Camilla A.; de Aguiar, Hulliana M.; Junqueira Júnior, Danilo G. title: Comparison of immunity against canine distemper, adenovirus and parvovirus after vaccination with two multivalent canine vaccines date: 2020-04-27 journal: Vet Med Sci DOI: 10.1002/vms3.274 sha: doc_id: 270998 cord_uid: 1adloi3o file: cache/cord-023364-ut56gczm.json key: cord-023364-ut56gczm authors: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00651.x sha: doc_id: 23364 cord_uid: ut56gczm file: cache/cord-272497-ww9o1kjr.json key: cord-272497-ww9o1kjr authors: Al-Anzi, Bader S.; Alenizi, Mohammad; Al Dallal, Jehad; Abookleesh, Frage Lhadi; Ullah, Aman title: An Overview of the World Current and Future Assessment of Novel COVID-19 Trajectory, Impact, and Potential Preventive Strategies at Healthcare Settings date: 2020-09-25 journal: Int J Environ Res Public Health DOI: 10.3390/ijerph17197016 sha: doc_id: 272497 cord_uid: ww9o1kjr file: cache/cord-274121-3w6kc0c9.json key: cord-274121-3w6kc0c9 authors: Ramiro, Sofia; Mostard, Rémy L M; Magro-Checa, César; van Dongen, Christel M P; Dormans, Tom; Buijs, Jacqueline; Gronenschild, Michiel; de Kruif, Martijn D; van Haren, Eric H J; van Kraaij, Tom; Leers, Mathie P G; Peeters, Ralph; Wong, Dennis R; Landewé, Robert B M title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 journal: Ann Rheum Dis DOI: 10.1136/annrheumdis-2020-218479 sha: doc_id: 274121 cord_uid: 3w6kc0c9 file: cache/cord-019347-tj3ye1mx.json key: cord-019347-tj3ye1mx authors: nan title: ABSTRACT BOOK date: 2010-02-19 journal: Ann Allergy Asthma Immunol DOI: 10.1016/s1081-1206(10)61294-x sha: doc_id: 19347 cord_uid: tj3ye1mx file: cache/cord-273839-oasgagpc.json key: cord-273839-oasgagpc authors: Bisno, Alan L.; Gerber, Michael A.; Jack M., Gwaltney; Kaplan, Edward L.; Schwartz, Richard H. title: Diagnosis and Management of Group A Streptococcal Pharyngitis: A Practice Guideline date: 1997-09-17 journal: Clin Infect Dis DOI: 10.1086/513768 sha: doc_id: 273839 cord_uid: oasgagpc file: cache/cord-274563-jimw6skv.json key: cord-274563-jimw6skv authors: Fiumara, Agata; Lanzafame, Giuseppina; Arena, Alessia; Sapuppo, Annamaria; Raudino, Federica; Praticò, Andrea; Pavone, Piero; Barone, Rita title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 journal: J Clin Med DOI: 10.3390/jcm9092716 sha: doc_id: 274563 cord_uid: jimw6skv file: cache/cord-022650-phsr10jp.json key: cord-022650-phsr10jp authors: nan title: Abstracts TPS date: 2018-08-14 journal: Allergy DOI: 10.1111/all.13539 sha: doc_id: 22650 cord_uid: phsr10jp file: cache/cord-274497-tqceazdp.json key: cord-274497-tqceazdp authors: N. Nuñez, Luis Fabian; Santander-Parra, Silvana H.; De la Torre, David I.; de Sá, Lilian R. M.; Buim, Marcos R.; Astolfi-Ferreira, Claudete S.; Piantino Ferreira, Antonio J. title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 journal: Pathogens DOI: 10.3390/pathogens9080606 sha: doc_id: 274497 cord_uid: tqceazdp file: cache/cord-280055-5iwo6tlb.json key: cord-280055-5iwo6tlb authors: Vieira, Tiago title: The lose-lose dilemmas of Barcelona’s platform delivery workers in the age of COVID-19 date: 2020-12-31 journal: Social Sciences & Humanities Open DOI: 10.1016/j.ssaho.2020.100059 sha: doc_id: 280055 cord_uid: 5iwo6tlb file: cache/cord-275499-25dp6u68.json key: cord-275499-25dp6u68 authors: Tan, Zhen; Dong, Wanting; Ding, Yaqun; Ding, Xiangdong; Zhang, Qin; Jiang, Li title: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets date: 2019-12-30 journal: Genes (Basel) DOI: 10.3390/genes11010044 sha: doc_id: 275499 cord_uid: 25dp6u68 file: cache/cord-275162-2239dk45.json key: cord-275162-2239dk45 authors: Gulla, Krishna Mohan; Balaji, Arvind; Mukherjee, Aparna; Jat, Kana Ram; Sankar, Jhuma; Lodha, Rakesh; Kabra, Sushil K title: Course of Illness after Viral Infection in Indian Children with Cystic Fibrosis date: 2018-06-09 journal: J Trop Pediatr DOI: 10.1093/tropej/fmy033 sha: doc_id: 275162 cord_uid: 2239dk45 file: cache/cord-278032-27ikx97x.json key: cord-278032-27ikx97x authors: GÖKER, Hakan; ALADAĞ-KARAKULAK, Elifcan; DEMİROĞLU, Haluk; AYAZ, Cağlayan Merve; BÜYÜKAŞIK, Yahya; İNKAYA, Ahmet Cağkan; AKSU, Salih; SAYINALP, Nilgün; C. HAZNEDAROĞLU, İbrahim; UZUN, Ömrüm; AKOVA, Murat; ÖZCEBE, Osman; ÜNAL, Serhat title: The effects of blood group types on the risk of COVID-19 infection and its clinical outcome date: 2020-06-23 journal: Turk J Med Sci DOI: 10.3906/sag-2005-395 sha: doc_id: 278032 cord_uid: 27ikx97x file: cache/cord-281309-c9y7m5do.json key: cord-281309-c9y7m5do authors: Guo, Baoqing; Lager, Kelly M.; Henningson, Jamie N.; Miller, Laura C.; Schlink, Sarah N.; Kappes, Matthew A.; Kehrli, Marcus E.; Brockmeier, Susan L.; Nicholson, Tracy L.; Yang, Han-Chun; Faaberg, Kay S. title: Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus date: 2013-01-20 journal: Virology DOI: 10.1016/j.virol.2012.09.013 sha: doc_id: 281309 cord_uid: c9y7m5do file: cache/cord-022633-fr55uod6.json key: cord-022633-fr55uod6 authors: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 journal: Acad Emerg Med DOI: 10.1111/j.1553-2712.2012.01332.x sha: doc_id: 22633 cord_uid: fr55uod6 file: cache/cord-023346-8sqbqjm1.json key: cord-023346-8sqbqjm1 authors: nan title: MONDAY: POSTERS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00652.x sha: doc_id: 23346 cord_uid: 8sqbqjm1 file: cache/cord-276288-upv2o8f6.json key: cord-276288-upv2o8f6 authors: Prior, Sarah Jane; Mather, Carey; Ford, Karen; Bywaters, Danielle; Campbell, Steven title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 journal: BMJ Open Qual DOI: 10.1136/bmjoq-2020-000912 sha: doc_id: 276288 cord_uid: upv2o8f6 file: cache/cord-015021-pol2qm74.json key: cord-015021-pol2qm74 authors: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 journal: Intensive Care Med DOI: 10.1007/bf02258437 sha: doc_id: 15021 cord_uid: pol2qm74 file: cache/cord-280064-rz8cglyt.json key: cord-280064-rz8cglyt authors: Gwizdałła, Tomasz title: Viral disease spreading in grouped population date: 2020-08-27 journal: Comput Methods Programs Biomed DOI: 10.1016/j.cmpb.2020.105715 sha: doc_id: 280064 cord_uid: rz8cglyt file: cache/cord-023354-f2ciho6o.json key: cord-023354-f2ciho6o authors: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 journal: Vox Sang DOI: 10.1111/j.1423-0410.2005.00654.x sha: doc_id: 23354 cord_uid: f2ciho6o file: cache/cord-275427-00bwhaga.json key: cord-275427-00bwhaga authors: Aydogdu, Ugur; Coskun, Alparslan; Atas, Ahmet Duran; Basbug, Onur; Agaoglu, Zahid Tevfik title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 journal: Small Ruminant Research DOI: 10.1016/j.smallrumres.2019.09.021 sha: doc_id: 275427 cord_uid: 00bwhaga file: cache/cord-280097-f7ky61ds.json key: cord-280097-f7ky61ds authors: Zarogoulidis, Paul; Constantinidis, Theodoros; Steiropoulos, Paschalis; Papanas, Nikolaos; Zarogoulidis, Kostas; Maltezos, Efstratios title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 journal: BMC Res Notes DOI: 10.1186/1756-0500-4-4 sha: doc_id: 280097 cord_uid: f7ky61ds file: cache/cord-282879-28nhr1hv.json key: cord-282879-28nhr1hv authors: Patel, Samir N.; Hsu, Jason; Sivalingam, Meera D.; Chiang, Allen; Kaiser, Richard S.; Mehta, Sonia; Park, Carl H.; Regillo, Carl D.; Sivalingam, Arunan; Vander, James F.; Ho, Allen C.; Garg, Sunir J. title: The impact of physician face mask use on endophthalmitis after intravitreal anti-vascular endothelial growth factor injections date: 2020-09-02 journal: Am J Ophthalmol DOI: 10.1016/j.ajo.2020.08.013 sha: doc_id: 282879 cord_uid: 28nhr1hv file: cache/cord-280036-ev82fzly.json key: cord-280036-ev82fzly authors: Almawly, J.; Prattley, D.; French, N.P.; Lopez-Villalobos, N.; Hedgespeth, B.; Grinberg, A. title: Utility of halofuginone lactate for the prevention of natural cryptosporidiosis of calves, in the presence of co-infection with rotavirus and Salmonella Typhimurium date: 2013-10-18 journal: Vet Parasitol DOI: 10.1016/j.vetpar.2013.04.029 sha: doc_id: 280036 cord_uid: ev82fzly file: cache/cord-278802-bverdk5w.json key: cord-278802-bverdk5w authors: Zhou, Yefei; Zhou, Meixian; Zhang, Dunlin; Zhang, Honglin; Zhang, Liyang title: Immune response of AA broilers to IBV H120 vaccine and sodium new houttuyfonate date: 2010-12-31 journal: Research in Veterinary Science DOI: 10.1016/j.rvsc.2010.04.010 sha: doc_id: 278802 cord_uid: bverdk5w file: cache/cord-284266-tbndldhr.json key: cord-284266-tbndldhr authors: Schippa, Serena; Frassanito, Antonella; Marazzato, Massimiliano; Nenna, Raffaella; Petrarca, Laura; Neroni, Bruna; Bonfiglio, Giulia; Guerrieri, Francesca; Frasca, Federica; Oliveto, Giuseppe; Pierangeli, Alessandra; Midulla, Fabio title: Nasal Microbiota in RSV Bronchiolitis date: 2020-05-13 journal: Microorganisms DOI: 10.3390/microorganisms8050731 sha: doc_id: 284266 cord_uid: tbndldhr file: cache/cord-284804-6i5zbmm1.json key: cord-284804-6i5zbmm1 authors: Pan, Feng; Yang, Lian; Li, Yuncheng; Liang, Bo; Li, Lin; Ye, Tianhe; Li, Lingli; Liu, Dehan; Gui, Shan; Hu, Yu; Zheng, Chuansheng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 journal: Int J Med Sci DOI: 10.7150/ijms.46614 sha: doc_id: 284804 cord_uid: 6i5zbmm1 file: cache/cord-283177-qwinggg4.json key: cord-283177-qwinggg4 authors: Viswanathan, Ramaswamy; Myers, Michael; Fanous, Ayman title: Support Groups and Individual Mental Health Care via Video Conferencing for Frontline Clinicians during the COVID-19 Pandemic date: 2020-06-23 journal: Psychosomatics DOI: 10.1016/j.psym.2020.06.014 sha: doc_id: 283177 cord_uid: qwinggg4 file: cache/cord-285136-07jcccv9.json key: cord-285136-07jcccv9 authors: Woo, Yu Ri; Park, Seo-Yeon; Choi, Keonwoo; Hong, Eun Sun; Kim, Sungjoo; Kim, Hei Sung title: Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM(10)) on an AD Mouse-Model date: 2020-08-24 journal: Int J Mol Sci DOI: 10.3390/ijms21176079 sha: doc_id: 285136 cord_uid: 07jcccv9 file: cache/cord-285323-473d7zvg.json key: cord-285323-473d7zvg authors: Jang, Hyesun; Koo, Bon-Sang; Jeon, Eun-Ok; Lee, Hae-Rim; Lee, Sang-Myeong; Mo, In-Pil title: Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus date: 2013-09-01 journal: Poult Sci DOI: 10.3382/ps.2013-03116 sha: doc_id: 285323 cord_uid: 473d7zvg file: cache/cord-284301-fg3hk94b.json key: cord-284301-fg3hk94b authors: Umemura, Yutaka; Yamakawa, Kazuma; Kiguchi, Takeyuki; Nishida, Takeshi; Kawada, Masahiro; Fujimi, Satoshi title: Hematological Phenotype of COVID-19-Induced Coagulopathy: Far from Typical Sepsis-Induced Coagulopathy date: 2020-09-05 journal: J Clin Med DOI: 10.3390/jcm9092875 sha: doc_id: 284301 cord_uid: fg3hk94b file: cache/cord-284635-79cgct71.json key: cord-284635-79cgct71 authors: Zanuzzi, C.N.; Nishida, F.; Portiansky, E.L.; Fontana, P.A.; Gimeno, E.J.; Barbeito, C.G. title: Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits date: 2011-08-20 journal: Res Vet Sci DOI: 10.1016/j.rvsc.2011.07.018 sha: doc_id: 284635 cord_uid: 79cgct71 file: cache/cord-023157-0lqlx2rv.json key: cord-023157-0lqlx2rv authors: nan title: Poster Sessions date: 2013-04-18 journal: J Diabetes DOI: 10.1111/1753-0407.12032_1 sha: doc_id: 23157 cord_uid: 0lqlx2rv file: cache/cord-286779-si3qml42.json key: cord-286779-si3qml42 authors: Li, Hai-yan; Zhang, Hong-lei; zhao, Fu-jie; Wang, Shi-qiong; Wang, Zhi-xiang; Wei, Zhan-yong title: Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks date: 2020-06-04 journal: Front Microbiol DOI: 10.3389/fmicb.2020.00897 sha: doc_id: 286779 cord_uid: si3qml42 file: cache/cord-023095-4dannjjm.json key: cord-023095-4dannjjm authors: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 journal: J Vet Intern Med DOI: 10.1111/j.1939-1676.2011.0726.x sha: doc_id: 23095 cord_uid: 4dannjjm file: cache/cord-286479-p9d78t6v.json key: cord-286479-p9d78t6v authors: nan title: NeoCORE Conference Abstracts date: 2020-07-09 journal: Indian J Pediatr DOI: 10.1007/s12098-020-03376-y sha: doc_id: 286479 cord_uid: p9d78t6v file: cache/cord-287431-bq0675h1.json key: cord-287431-bq0675h1 authors: Romano, Mario R.; Ferrara, Mariantonia; Rocha-de-Lossada, Carlos; Angi, Martina; Govetto, Andrea; Mastropasqua, Rodolfo; Romano, Vito title: Active e-learning in ophthalmology through live webinars: back to the theatre date: 2020-10-28 journal: Eye (Lond) DOI: 10.1038/s41433-020-01239-6 sha: doc_id: 287431 cord_uid: bq0675h1 file: cache/cord-288528-f6oz6zyz.json key: cord-288528-f6oz6zyz authors: Pastakia, Sonak D.; Braitstein, Paula; Galárraga, Omar; Genberg, Becky; Said, Jamil; Vedanthan, Rajesh; Wachira, Juddy; Hogan, Joseph W. title: Preserving 2 decades of healthcare gains for Africa in the coronavirus disease 2019 era date: 2020-10-01 journal: AIDS DOI: 10.1097/qad.0000000000002605 sha: doc_id: 288528 cord_uid: f6oz6zyz file: cache/cord-286539-3sr4djft.json key: cord-286539-3sr4djft authors: Mentus, Cassidy; Romeo, Martin; DiPaola, Christian title: Analysis and Applications of Adaptive Group Testing Methods for COVID-19 date: 2020-04-07 journal: nan DOI: 10.1101/2020.04.05.20050245 sha: doc_id: 286539 cord_uid: 3sr4djft file: cache/cord-288552-7lp07v5i.json key: cord-288552-7lp07v5i authors: Vahedi, Ensieh; Ghanei, Mostafa; Ghazvini, Ali; Azadi, Hossein; Izadi, Morteza; Panahi, Yunes; Fathi, Saeid; Salesi, Mahmood; Saadat, Seyed Hassan; Ghazale, Amir Hossein; Rezapour, Mohammad; Mozafari, Abolfazl; Zand, Nahid; Parsaei, Mohammadreza Raesi; Ranjkesh, Mohammad Hossein; Jafari, Ramezan; Movaseghi, Fatemeh; Darabi, Enayat title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 journal: Daru DOI: 10.1007/s40199-020-00353-w sha: doc_id: 288552 cord_uid: 7lp07v5i file: cache/cord-005814-ak5pq312.json key: cord-005814-ak5pq312 authors: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 journal: Intensive Care Med DOI: 10.1007/bf02426401 sha: doc_id: 5814 cord_uid: ak5pq312 file: cache/cord-289865-36ai2xgy.json key: cord-289865-36ai2xgy authors: Paddon, Laura Isobel title: Therapeutic or detrimental mobilities? Walking groups for older adults date: 2020-04-28 journal: Health Place DOI: 10.1016/j.healthplace.2020.102346 sha: doc_id: 289865 cord_uid: 36ai2xgy file: cache/cord-294175-nu6q2ddu.json key: cord-294175-nu6q2ddu authors: Saitoh, Masayuki; Tsuchida, Masanori; Koike, Terumoto; Satoh, Koichi; Haga, Manabu; Aoki, Tadashi; Toyabe, Shin-ichi; Hayashi, Jun-ichi title: Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation date: 2006-12-31 journal: The Journal of Thoracic and Cardiovascular Surgery DOI: 10.1016/j.jtcvs.2006.08.020 sha: doc_id: 294175 cord_uid: nu6q2ddu file: cache/cord-298569-174bzxdh.json key: cord-298569-174bzxdh authors: Gånheim, Charina; Alenius, Stefan; Persson Waller, Karin title: Acute phase proteins as indicators of calf herd health date: 2006-03-20 journal: Vet J DOI: 10.1016/j.tvjl.2006.01.011 sha: doc_id: 298569 cord_uid: 174bzxdh file: cache/cord-294839-qxn22td0.json key: cord-294839-qxn22td0 authors: Ibfelt, T.; Engelund, E.H.; Schultz, A.C.; Andersen, L.P. title: Effect of cleaning and disinfection of toys on infectious diseases and micro-organisms in daycare nurseries date: 2014-12-01 journal: J Hosp Infect DOI: 10.1016/j.jhin.2014.10.007 sha: doc_id: 294839 cord_uid: qxn22td0 file: cache/cord-290465-tvegf0kt.json key: cord-290465-tvegf0kt authors: Brook, Judy; Leanne Aitken; MacLaren, Dr Julie; Debra Salmon title: Co-production of an intervention to increase retention of early career nurses: Acceptability and feasibility date: 2020-08-15 journal: Nurse Educ Pract DOI: 10.1016/j.nepr.2020.102861 sha: doc_id: 290465 cord_uid: tvegf0kt file: cache/cord-290256-mkfg7nar.json key: cord-290256-mkfg7nar authors: Ren, Zhigang; Luo, Hong; Yu, Zujiang; Song, Jingchao; Liang, Lan; Wang, Ling; Wang, Haiyu; Cui, Guangying; Liu, Yong; Wang, Jin; Li, Qingquan; Zeng, Zhaohai; Yang, Shengkun; Pei, Guangzhong; Zhu, Yonghui; Song, Wenbin; Yu, Wenquan; Song, Chuanjun; Dong, Lihong; Hu, Chuansong; Du, Jinfa; Chang, Junbiao title: A Randomized, Open‐label, Controlled Clinical Trial of Azvudine Tablets in the Treatment of Mild and Common COVID‐19, A Pilot Study date: 2020-07-14 journal: Adv Sci (Weinh) DOI: 10.1002/advs.202001435 sha: doc_id: 290256 cord_uid: mkfg7nar file: cache/cord-296606-aizjzglo.json key: cord-296606-aizjzglo authors: Guo, Tingting; Liu, Xiaoming; Xu, Cihao; Wang, Jiazheng; Yang, Lian; Shi, Heshui; Dai, Meng title: Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients date: 2020-07-30 journal: Int J Med Sci DOI: 10.7150/ijms.48074 sha: doc_id: 296606 cord_uid: aizjzglo file: cache/cord-301687-wadf3c3i.json key: cord-301687-wadf3c3i authors: Li, Yan; Yang, Zhenlu; Ai, Tao; Wu, Shandong; Xia, Liming title: Association of “initial CT” findings with mortality in older patients with coronavirus disease 2019 (COVID-19) date: 2020-06-10 journal: Eur Radiol DOI: 10.1007/s00330-020-06969-5 sha: doc_id: 301687 cord_uid: wadf3c3i file: cache/cord-299691-jton1oig.json key: cord-299691-jton1oig authors: Jové-Blanco, A.; Solís-García, G.; Torres-Soblechero, L.; Escobar-Castellanos, M.; Mora-Capín, A.; Rivas-García, A.; Castro-Rodríguez, C.; Marañón, R. title: Video discharge instructions for pediatric gastroenteritis in an emergency department: a randomized, controlled trial date: 2020-10-08 journal: Eur J Pediatr DOI: 10.1007/s00431-020-03827-w sha: doc_id: 299691 cord_uid: jton1oig file: cache/cord-298582-25qn9d15.json key: cord-298582-25qn9d15 authors: Snyder, N.L.; Seeberger, P.H.; Mukosera, G.T.; Held, E.M.K. title: 9.05 Technology-Enabled Synthesis of Carbohydrates date: 2014-02-18 journal: Comprehensive Organic Synthesis II DOI: 10.1016/b978-0-08-097742-3.00914-9 sha: doc_id: 298582 cord_uid: 25qn9d15 file: cache/cord-297138-t8b3914h.json key: cord-297138-t8b3914h authors: Duijker, G.; Bertsias, A.; Symvoulakis, E. K.; Moschandreas, J.; Malliaraki, N.; Derdas, S. P.; Tsikalas, G. K.; Katerinopoulos, H. E.; Pirintsos, S. A.; Sourvinos, G.; Castanas, E.; Lionis, C. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 journal: Journal of Ethnopharmacology DOI: 10.1016/j.jep.2015.01.030 sha: doc_id: 297138 cord_uid: t8b3914h file: cache/cord-303378-cfbvka30.json key: cord-303378-cfbvka30 authors: Zhang, Shi-Jin; Chen, Zhuo; Li, Guo-Wen; Wang, Bo-Liang title: Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia date: 2013-08-31 journal: Asian Pacific Journal of Tropical Medicine DOI: 10.1016/s1995-7645(13)60113-3 sha: doc_id: 303378 cord_uid: cfbvka30 file: cache/cord-295987-die9jmbv.json key: cord-295987-die9jmbv authors: Chabre, Yoann M.; Roy, René title: Design and Creativity in Synthesis of Multivalent Neoglycoconjugates date: 2010-04-08 journal: Adv Carbohydr Chem Biochem DOI: 10.1016/s0065-2318(10)63006-5 sha: doc_id: 295987 cord_uid: die9jmbv file: cache/cord-305092-q4tlj1jd.json key: cord-305092-q4tlj1jd authors: Lu, Jingjing; Yin, Qi; Li, Quan; Fu, Gang; Hu, Xueping; Huang, Jianhao; Chen, Lin; Li, Qiang; Guo, Zhongliang title: Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China date: 2020-08-29 journal: J Clin Lab Anal DOI: 10.1002/jcla.23534 sha: doc_id: 305092 cord_uid: q4tlj1jd file: cache/cord-302305-xr067v2n.json key: cord-302305-xr067v2n authors: van Aalst, Jan title: Distinguishing knowledge-sharing, knowledge-construction, and knowledge-creation discourses date: 2009-06-20 journal: Int J Comput Support Collab Learn DOI: 10.1007/s11412-009-9069-5 sha: doc_id: 302305 cord_uid: xr067v2n file: cache/cord-302079-pby3i6wq.json key: cord-302079-pby3i6wq authors: Deng, Yan; Liu, Wei; Liu, Kui; Fang, Yuan-Yuan; Shang, Jin; Zhou, Ling; Wang, Ke; Leng, Fan; Wei, Shuang; Chen, Lei; Liu, Hui-Guo title: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study date: 2020-06-05 journal: Chin Med J (Engl) DOI: 10.1097/cm9.0000000000000824 sha: doc_id: 302079 cord_uid: pby3i6wq file: cache/cord-298534-1j8jkfn9.json key: cord-298534-1j8jkfn9 authors: Zhu, H.; Qu, G.; Yu, H.; Huang, G.; Chen, L.; Zhang, M.; Wan, S.; Pei, B. title: Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study date: 2020-11-03 journal: nan DOI: 10.1101/2020.10.29.20222612 sha: doc_id: 298534 cord_uid: 1j8jkfn9 file: cache/cord-302695-vyo3w2a4.json key: cord-302695-vyo3w2a4 authors: Albertini, Laetitia; Soletchnik, Mickael; Razurel, Anais; Cohen, Johana; Bidegain, Frédéric; Fauvelle, Francis; Safrano, Geoffroy; Piquet, Jacques; Maurer, Cyril; Goldgran-Toledano, Dany title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 journal: Eur J Hosp Pharm DOI: 10.1136/ejhpharm-2020-002414 sha: doc_id: 302695 cord_uid: vyo3w2a4 file: cache/cord-303807-fka9svzu.json key: cord-303807-fka9svzu authors: Gerber, Michael A. title: Diagnosis and Treatment of Pharyngitis in Children date: 2005-05-28 journal: Pediatr Clin North Am DOI: 10.1016/j.pcl.2005.02.004 sha: doc_id: 303807 cord_uid: fka9svzu file: cache/cord-304208-jwlc8fxj.json key: cord-304208-jwlc8fxj authors: Vagni, Monia; Maiorano, Tiziana; Giostra, Valeria; Pajardi, Daniela title: Coping With COVID-19: Emergency Stress, Secondary Trauma and Self-Efficacy in Healthcare and Emergency Workers in Italy date: 2020-09-03 journal: Front Psychol DOI: 10.3389/fpsyg.2020.566912 sha: doc_id: 304208 cord_uid: jwlc8fxj file: cache/cord-298931-n1se3ajb.json key: cord-298931-n1se3ajb authors: Stańdo, Mirella; Piatek, Paweł; Namiecinska, Magdalena; Lewkowicz, Przemysław; Lewkowicz, Natalia title: Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial date: 2020-08-27 journal: Nutrients DOI: 10.3390/nu12092614 sha: doc_id: 298931 cord_uid: n1se3ajb file: cache/cord-318248-y2vkpuv3.json key: cord-318248-y2vkpuv3 authors: nan title: Global Initiative for Chronic Obstructive Lung Disease strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: An Asia–Pacific perspective date: 2005-02-03 journal: Respirology DOI: 10.1111/j.1440-1843.2005.00692.x sha: doc_id: 318248 cord_uid: y2vkpuv3 file: cache/cord-300046-orlga9qf.json key: cord-300046-orlga9qf authors: Gomes da Silva, J.; Sofia Silva, C.; Alexandre, B.; Morgado, P. title: Health literacy of inland population in the mitigation phase 3.2. of COVID-19's pandemic in Portugal - a descriptive cohort study date: 2020-05-14 journal: nan DOI: 10.1101/2020.05.11.20098061 sha: doc_id: 300046 cord_uid: orlga9qf file: cache/cord-312497-6cd7dolj.json key: cord-312497-6cd7dolj authors: Mishra, Anurag; Bains, Lovenish; Jesudin, Gnanaraj; Aruparayil, Noel; Singh, Rajdeep; Shashi title: Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Low- to Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study date: 2020-08-19 journal: J Am Coll Surg DOI: 10.1016/j.jamcollsurg.2020.07.783 sha: doc_id: 312497 cord_uid: 6cd7dolj file: cache/cord-299881-weptfpa2.json key: cord-299881-weptfpa2 authors: Halvachizadeh, Sascha; Teuben, Michel; Berk, Till; Neuhaus, Valentin; Pape, Hans-Christoph; Pfeifer, Roman title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 journal: Int Orthop DOI: 10.1007/s00264-020-04740-5 sha: doc_id: 299881 cord_uid: weptfpa2 file: cache/cord-317410-hc06yo32.json key: cord-317410-hc06yo32 authors: Muthanna, Abdulrahman; Salim, Hani Syahida; Hamat, Rukman Awang; Shamsuddin, Nurainul Hana; Zakariah, Siti Zulaikha title: Clinical Screening Tools to Diagnose Group A Streptococcal Pharyngotonsillitis in Primary Care Clinics to Improve Prescribing Habits date: 2018-12-28 journal: Malays J Med Sci DOI: 10.21315/mjms2018.25.6.2 sha: doc_id: 317410 cord_uid: hc06yo32 file: cache/cord-317347-by8albr9.json key: cord-317347-by8albr9 authors: van Ginkel, Frederik W.; Padgett, Justin; Martinez-Romero, Gisela; Miller, Matthew S.; Joiner, Kellye S.; Gulley, Stephen L. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 journal: Vaccine DOI: 10.1016/j.vaccine.2015.04.026 sha: doc_id: 317347 cord_uid: by8albr9 file: cache/cord-312695-1uw8xcxw.json key: cord-312695-1uw8xcxw authors: Sugiarto, Sarah; Spiri, Andrea M.; Riond, Barbara; Novacco, Marilisa; Oestmann, Angelina; de Miranda, Luisa H. Monteiro; Meli, Marina L.; Boretti, Felicitas S.; Hofmann-Lehmann, Regina; Willi, Barbara title: Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis date: 2016-08-05 journal: Vet Res DOI: 10.1186/s13567-016-0361-x sha: doc_id: 312695 cord_uid: 1uw8xcxw file: cache/cord-306145-5uf0hj6a.json key: cord-306145-5uf0hj6a authors: Nalbantoglu, Ozkan Ufuk title: Group testing performance evaluation for SARS-CoV-2 massive scale screening and testing date: 2020-07-02 journal: BMC Med Res Methodol DOI: 10.1186/s12874-020-01048-1 sha: doc_id: 306145 cord_uid: 5uf0hj6a file: cache/cord-322789-9elfpx0e.json key: cord-322789-9elfpx0e authors: Abbaspour Kasgari, Hamideh; Moradi, Siavash; Shabani, Amir Mohammad; Babamahmoodi, Farhang; Davoudi Badabi, Ali Reza; Davoudi, Lotfollah; Alikhani, Ahmad; Hedayatizadeh Omran, Akbar; Saeedi, Majid; Merat, Shahin; Wentzel, Hannah; Garratt, Anna; Levi, Jacob; Simmons, Bryony; Hill, Andrew; Tirgar Fakheri, Hafez title: Evaluation of the efficacy of sofosbuvir plus daclatasvir in combination with ribavirin for hospitalized COVID-19 patients with moderate disease compared with standard care: a single-centre, randomized controlled trial date: 2020-08-19 journal: J Antimicrob Chemother DOI: 10.1093/jac/dkaa332 sha: doc_id: 322789 cord_uid: 9elfpx0e file: cache/cord-317344-wznzmssz.json key: cord-317344-wznzmssz authors: Iannitti, T.; Palmieri, B. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 journal: Clin Nutr DOI: 10.1016/j.clnu.2010.05.004 sha: doc_id: 317344 cord_uid: wznzmssz file: cache/cord-324326-q014b5ym.json key: cord-324326-q014b5ym authors: MURAKAMI, Makoto title: Lipoquality control by phospholipase A(2) enzymes date: 2017-11-10 journal: Proc Jpn Acad Ser B Phys Biol Sci DOI: 10.2183/pjab.93.043 sha: doc_id: 324326 cord_uid: q014b5ym file: cache/cord-326431-42luhd4s.json key: cord-326431-42luhd4s authors: Järvelä, Sanna; Rosé, Carolyn P. title: Advocating for group interaction in the age of COVID-19 date: 2020-07-08 journal: Int J Comput Support Collab Learn DOI: 10.1007/s11412-020-09324-4 sha: doc_id: 326431 cord_uid: 42luhd4s file: cache/cord-329468-vjsurl60.json key: cord-329468-vjsurl60 authors: Okino, Cintia Hiromi; Mores, Marcos Antônio Zanella; Trevisol, Iara Maria; Coldebella, Arlei; Montassier, Hélio José; Brentano, Liana title: Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles date: 2017-02-15 journal: PLoS One DOI: 10.1371/journal.pone.0172275 sha: doc_id: 329468 cord_uid: vjsurl60 file: cache/cord-329669-z3t7plvh.json key: cord-329669-z3t7plvh authors: Poulton, Kay; Wright, Paul; Hughes, Pamela; Savic, Sinisa; Welberry Smith, Matthew; Guiver, Malcolm; Morton, Muir; van Dellen, David; Tholouli, Eleni; Wynn, Robert; Clark, Brendan title: A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients date: 2020-07-05 journal: Int J Immunogenet DOI: 10.1111/iji.12505 sha: doc_id: 329669 cord_uid: z3t7plvh file: cache/cord-326747-zwp13awk.json key: cord-326747-zwp13awk authors: Sever, Mustafa; Mordeniz, Cengiz; Sever, Fidan; Dokur, Mehmet title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 journal: J Clin Med Res DOI: 10.4021/jocmr2009.12.1283 sha: doc_id: 326747 cord_uid: zwp13awk file: cache/cord-323906-ro078y52.json key: cord-323906-ro078y52 authors: Sardu, Celestino; Marfella, Raffaele; Maggi, Paolo; Messina, Vincenzo; Cirillo, Paolo; Codella, Vinicio; Gambardella, Jessica; Sardu, Antonio; Gatta, Gianluca; Santulli, Gaetano; Paolisso, Giuseppe title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 journal: BMC Cardiovasc Disord DOI: 10.1186/s12872-020-01658-z sha: doc_id: 323906 cord_uid: ro078y52 file: cache/cord-326723-jiauk4fq.json key: cord-326723-jiauk4fq authors: Risalde, María A; Molina, Verónica; Sánchez-Cordón, Pedro J; Romero-Palomo, Fernando; Pedrera, Miriam; Garfia, Bartolomé; Gómez-Villamandos, José C title: Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1 date: 2013-03-18 journal: Vet Res DOI: 10.1186/1297-9716-44-20 sha: doc_id: 326723 cord_uid: jiauk4fq file: cache/cord-332735-vfnbs2jn.json key: cord-332735-vfnbs2jn authors: Rebmann, Terri; Wagner, William title: Infection preventionists' experience during the first months of the 2009 novel H1N1 influenza A pandemic date: 2009-12-31 journal: American Journal of Infection Control DOI: 10.1016/j.ajic.2009.09.003 sha: doc_id: 332735 cord_uid: vfnbs2jn file: cache/cord-333334-90q1xkld.json key: cord-333334-90q1xkld authors: Shengchen, D.; Gu, X.; Fan, G.; Sun, R.; Wang, Y.; Yu, D.; Li, H.; Zhou, F.; Xiong, Z.; Lu, B.; Zhu, G.; Cao, B. title: Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial date: 2019-06-20 journal: Clin Microbiol Infect DOI: 10.1016/j.cmi.2019.06.012 sha: doc_id: 333334 cord_uid: 90q1xkld file: cache/cord-329856-0m5mc320.json key: cord-329856-0m5mc320 authors: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 journal: Inform Med Unlocked DOI: 10.1016/j.imu.2020.100364 sha: doc_id: 329856 cord_uid: 0m5mc320 file: cache/cord-333745-nwnt2tde.json key: cord-333745-nwnt2tde authors: Wang, Yi; Yao, Lin; Zhang, Jian-Ping; Tang, Pei-Jun; Ye, Zhi-Jian; Shen, Xing-Hua; Xu, Jun-Chi; Wu, Mei-Ying; Yu, Xin title: Clinical characteristics and laboratory indicator analysis of 67 COVID-19 pneumonia patients in Suzhou, China date: 2020-10-12 journal: BMC Infect Dis DOI: 10.1186/s12879-020-05468-8 sha: doc_id: 333745 cord_uid: nwnt2tde file: cache/cord-331270-12zx0o2p.json key: cord-331270-12zx0o2p authors: Rico, Timóteo Matthies; dos Santos Machado, Karina; Fernandes, Vanessa Pellegrini; Madruga, Samanta Winck; Santin, Mateus Madail; Petrarca, Cristiane Rios; Dumith, Samuel Carvalho title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 journal: J Med Syst DOI: 10.1007/s10916-020-01663-x sha: doc_id: 331270 cord_uid: 12zx0o2p file: cache/cord-342381-i63r6los.json key: cord-342381-i63r6los authors: Wu, Huiyue; Cai, Tong; Liu, Yingxin; Luo, Dan; Zhang, Zhian title: Design and development of an immersive virtual reality news application: a case study of the SARS event date: 2020-09-17 journal: Multimed Tools Appl DOI: 10.1007/s11042-020-09863-w sha: doc_id: 342381 cord_uid: i63r6los file: cache/cord-337644-aobdzwpx.json key: cord-337644-aobdzwpx authors: Pianta, L.; Vinciguerra, A.; Bertazzoni, G.; Morello, R.; Mangiatordi, F.; Lund, V. J.; Trimarchi, M. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 journal: Eur Arch Otorhinolaryngol DOI: 10.1007/s00405-020-06067-8 sha: doc_id: 337644 cord_uid: aobdzwpx file: cache/cord-341397-gl8xzzdv.json key: cord-341397-gl8xzzdv authors: Bhavani, Sivasubramanium V.; Huang, Elbert S.; Verhoef, Philip A.; Churpek, Matthew M. title: Novel Temperature Trajectory Subphenotypes in COVID-19 date: 2020-07-21 journal: Chest DOI: 10.1016/j.chest.2020.07.027 sha: doc_id: 341397 cord_uid: gl8xzzdv file: cache/cord-343418-519vkzci.json key: cord-343418-519vkzci authors: Li, Hao; Shi, Yongmin title: Study on the Performance Degradation of Sandstone under Acidification date: 2020-10-21 journal: ACS Omega DOI: 10.1021/acsomega.0c04312 sha: doc_id: 343418 cord_uid: 519vkzci file: cache/cord-336192-5uxq5xrs.json key: cord-336192-5uxq5xrs authors: Alavi, Maryam; Moghanibashi-Mansourieh, Amir; Radfar, Seyed Ramin; Alizadeh, Sepideh; Bahramabadian, Fatemeh; Esmizade, Sara; Dore, Gregory J.; Sedeh, Farid Barati; Deilamizade, Abbas title: Coordination, cooperation, and creativity within harm reduction networks in Iran: COVID-19 prevention and control among people who use drugs date: 2020-08-17 journal: Int J Drug Policy DOI: 10.1016/j.drugpo.2020.102908 sha: doc_id: 336192 cord_uid: 5uxq5xrs file: cache/cord-344121-k58c0jf3.json key: cord-344121-k58c0jf3 authors: Lundgren, A.-L.; Johannisson, A.; Zimmermann, W.; Bode, L.; Rozell, B.; Muluneh, A.; Lindberg, R.; Ludwig, H. title: Neurological disease and encephalitis in cats experimentally infected with Borna disease virus date: 1997 journal: Acta Neuropathol DOI: 10.1007/s004010050630 sha: doc_id: 344121 cord_uid: k58c0jf3 file: cache/cord-347960-vl5zhxyh.json key: cord-347960-vl5zhxyh authors: Giallonardo, Vincenzo; Sampogna, Gaia; Del Vecchio, Valeria; Luciano, Mario; Albert, Umberto; Carmassi, Claudia; Carrà, Giuseppe; Cirulli, Francesca; Dell’Osso, Bernardo; Nanni, Maria Giulia; Pompili, Maurizio; Sani, Gabriele; Tortorella, Alfonso; Volpe, Umberto; Fiorillo, Andrea title: The Impact of Quarantine and Physical Distancing Following COVID-19 on Mental Health: Study Protocol of a Multicentric Italian Population Trial date: 2020-06-05 journal: Front Psychiatry DOI: 10.3389/fpsyt.2020.00533 sha: doc_id: 347960 cord_uid: vl5zhxyh file: cache/cord-339705-x8l3zgfd.json key: cord-339705-x8l3zgfd authors: Patil, Vijaykumar; Ingle, D. R. title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 journal: Artif Intell Rev DOI: 10.1007/s10462-020-09891-w sha: doc_id: 339705 cord_uid: x8l3zgfd file: cache/cord-342391-arp07mck.json key: cord-342391-arp07mck authors: Magiorkinis, G.; Magiorkinis, E.; Paraskevis, D.; Vandamme, A.M.; Van Ranst, M.; Moulton, V.; Hatzakis, A. title: Phylogenetic analysis of the full‐length SARS‐CoV sequences: Evidence for phylogenetic discordance in three genomic regions date: 2004-09-14 journal: J Med Virol DOI: 10.1002/jmv.20187 sha: doc_id: 342391 cord_uid: arp07mck file: cache/cord-342210-r8vxz5vu.json key: cord-342210-r8vxz5vu authors: Mukherjee, Pranab K.; Esper, Frank; Buchheit, Ken; Arters, Karen; Adkins, Ina; Ghannoum, Mahmoud A.; Salata, Robert A. title: Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections date: 2017-01-14 journal: BMC Infect Dis DOI: 10.1186/s12879-016-2177-8 sha: doc_id: 342210 cord_uid: r8vxz5vu file: cache/cord-353256-7nfklun9.json key: cord-353256-7nfklun9 authors: Eroglu‐Ertugrul, Nesibe Gevher; Yalcin, Ebru; Oguz, Berna; Ocal, Turgay; Kuskonmaz, Baris; Emiralioglu, Nagehan; Dogru‐Ersoz, Deniz; Ozcelik, Ugur; Tezcan, Ilhan; Kiper, Nural title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 journal: Clin Respir J DOI: 10.1111/crj.13103 sha: doc_id: 353256 cord_uid: 7nfklun9 file: cache/cord-344411-lkgcxjya.json key: cord-344411-lkgcxjya authors: Huang, Qiqi; Gao, Xiaona; Liu, Ping; Lin, Huayuan; Liu, Weilian; Liu, Guohui; Zhang, Jin; Deng, Guangfu; Zhang, Caiying; Cao, Huabin; Guo, Xiaoquan; Hu, Guoliang title: The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens date: 2017-06-01 journal: Poultry Science DOI: 10.3382/ps/pew455 sha: doc_id: 344411 cord_uid: lkgcxjya file: cache/cord-335975-m6lkrehi.json key: cord-335975-m6lkrehi authors: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 journal: Ann Intensive Care DOI: 10.1186/s13613-017-0345-7 sha: doc_id: 335975 cord_uid: m6lkrehi file: cache/cord-348785-f67amppy.json key: cord-348785-f67amppy authors: Kapicibaşi, Hasan Oğuz; Kiraz, Hasan Ali; Demir, Emin Tunç; Adali, Yasemen; Elmas, Sait title: Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model date: 2020-07-13 journal: Acta cirurgica brasileira DOI: 10.1590/s0102-865020200060000004 sha: doc_id: 348785 cord_uid: f67amppy file: cache/cord-355190-ytdw1d5v.json key: cord-355190-ytdw1d5v authors: Mok, Chi Chiu; Ho, Ling Yin; Chan, Kar Li; Tse, Sau Mei; To, Chi Hung title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 journal: Front Med (Lausanne) DOI: 10.3389/fmed.2020.00552 sha: doc_id: 355190 cord_uid: ytdw1d5v file: cache/cord-349720-2lxab3u2.json key: cord-349720-2lxab3u2 authors: Qin, Ling; Yao, Dong; Zheng, Lizhen; Liu, Wai-Ching; Liu, Zhong; Lei, Ming; Huang, Le; Xie, Xinhui; Wang, Xinluan; Chen, Yang; Yao, Xinsheng; Peng, Jiang; Gong, He; Griffith, James F.; Huang, Yanping; Zheng, Yongping; Feng, Jian Q.; Liu, Ying; Chen, Shihui; Xiao, Deming; Wang, Daping; Xiong, Jiangyi; Pei, Duanqing; Zhang, Peng; Pan, Xiaohua; Wang, Xiaohong; Lee, Kwong-Man; Cheng, Chun-Yiu title: Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits date: 2015-05-15 journal: Biomaterials DOI: 10.1016/j.biomaterials.2015.04.038 sha: doc_id: 349720 cord_uid: 2lxab3u2 file: cache/cord-009997-oecpqf1j.json key: cord-009997-oecpqf1j authors: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 journal: Pediatr Blood Cancer DOI: 10.1002/pbc.27057 sha: doc_id: 9997 cord_uid: oecpqf1j file: cache/cord-355038-o2hr5mox.json key: cord-355038-o2hr5mox authors: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 journal: Ann Intensive Care DOI: 10.1186/s13613-020-0623-7 sha: doc_id: 355038 cord_uid: o2hr5mox file: cache/cord-341063-3rqnu5bu.json key: cord-341063-3rqnu5bu authors: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 journal: Crit Care DOI: 10.1186/s13054-018-1973-5 sha: doc_id: 341063 cord_uid: 3rqnu5bu file: cache/cord-015354-yknwveyz.json key: cord-015354-yknwveyz authors: nan title: Abstracts_Poster presentations date: 2007-09-18 journal: Eur J Nucl Med Mol Imaging DOI: 10.1007/s00259-007-0544-9 sha: doc_id: 15354 cord_uid: yknwveyz file: cache/cord-015324-y44sfr0c.json key: cord-015324-y44sfr0c authors: nan title: Scientific Programme date: 2007-09-01 journal: Pediatr Nephrol DOI: 10.1007/s00467-007-0558-3 sha: doc_id: 15324 cord_uid: y44sfr0c file: cache/cord-010092-uftc8inx.json key: cord-010092-uftc8inx authors: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 journal: Vox Sang DOI: 10.1111/vox.12792 sha: doc_id: 10092 cord_uid: uftc8inx file: cache/cord-022940-atbjwpo5.json key: cord-022940-atbjwpo5 authors: nan title: Poster Sessions date: 2016-09-07 journal: FEBS J DOI: 10.1111/febs.13808 sha: doc_id: 22940 cord_uid: atbjwpo5 file: cache/cord-005453-4057qib7.json key: cord-005453-4057qib7 authors: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 journal: Bone Marrow Transplant DOI: 10.1038/s41409-019-0559-4 sha: doc_id: 5453 cord_uid: 4057qib7 Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-group-cord parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26302 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 25678 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24805 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26456 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23388 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 25792 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 24339 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 25464 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26254 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/cordpos2carrel.sh: fork: retry: No child processes /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26159 Aborted $FILE2BIB "$FILE" > "$OUTPUT" /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. parallel: Warning: No more processes: Decreasing number of running jobs to 94. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26516 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 26252 Aborted $FILE2BIB "$FILE" > "$OUTPUT" parallel: Warning: No more processes: Decreasing number of running jobs to 95. parallel: Warning: Raising ulimit -u or /etc/security/limits.conf may help. /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: Resource temporarily unavailable /data-disk/reader-compute/reader-cord/bin/txt2urls.sh: fork: retry: No child processes === file2bib.sh === id: cord-014868-kg96uvpi author: Vita, S. title: Evaluation of Total Proteins and Serum Protein Fractions in Cats Naturally Infected by Leishmania infantum–A Preliminary Study date: 2006 pages: extension: .txt txt: ./txt/cord-014868-kg96uvpi.txt cache: ./cache/cord-014868-kg96uvpi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-014868-kg96uvpi.txt' === file2bib.sh === id: cord-010390-lc22hp3o author: Nenna, Raffaella title: Age Limit in Bronchiolitis Diagnosis: 6 or 12 Months? date: 2020-04-20 pages: extension: .txt txt: ./txt/cord-010390-lc22hp3o.txt cache: ./cache/cord-010390-lc22hp3o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010390-lc22hp3o.txt' === file2bib.sh === id: cord-012537-49v45di6 author: El-Ghandour, Mamdouh title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial date: 2020-08-28 pages: extension: .txt txt: ./txt/cord-012537-49v45di6.txt cache: ./cache/cord-012537-49v45di6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-012537-49v45di6.txt' === file2bib.sh === id: cord-010501-kd95xvsg author: Zenetos, Argyro title: Analysis of Benthic Communities in the Cyclades Plateau (Aegean Sea) Using Ecological and Paleoecological Data Sets date: 2008-06-28 pages: extension: .txt txt: ./txt/cord-010501-kd95xvsg.txt cache: ./cache/cord-010501-kd95xvsg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010501-kd95xvsg.txt' === file2bib.sh === id: cord-004342-9uok77wb author: Lin, Chun-Yu title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 pages: extension: .txt txt: ./txt/cord-004342-9uok77wb.txt cache: ./cache/cord-004342-9uok77wb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004342-9uok77wb.txt' === file2bib.sh === id: cord-026493-z2hthkgy author: Newsom, Megan title: New and Emerging Systemic Treatments for Atopic Dermatitis date: 2020-06-09 pages: extension: .txt txt: ./txt/cord-026493-z2hthkgy.txt cache: ./cache/cord-026493-z2hthkgy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-026493-z2hthkgy.txt' === file2bib.sh === id: cord-003024-17f1evh3 author: Nunes, Márcio Roberto Teixeira title: Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas date: 2018-05-24 pages: extension: .txt txt: ./txt/cord-003024-17f1evh3.txt cache: ./cache/cord-003024-17f1evh3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003024-17f1evh3.txt' === file2bib.sh === id: cord-010530-w8ir0e07 author: MOURA, HERCULES title: Acanthamoeba healyi N. Sp. and the Isoenzyme and Immunoblot Profiles of Acanthamoeba spp., Groups 1 and 3 date: 2007-05-01 pages: extension: .txt txt: ./txt/cord-010530-w8ir0e07.txt cache: ./cache/cord-010530-w8ir0e07.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-010530-w8ir0e07.txt' === file2bib.sh === id: cord-018813-9hoksa86 author: Waito, Marianne title: A Mathematical Model of Cytokine Dynamics During a Cytokine Storm date: 2016-02-17 pages: extension: .txt txt: ./txt/cord-018813-9hoksa86.txt cache: ./cache/cord-018813-9hoksa86.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-018813-9hoksa86.txt' === file2bib.sh === id: cord-001809-azb7nie3 author: Qvarnstrom, Yvonne title: Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis date: 2013-07-24 pages: extension: .txt txt: ./txt/cord-001809-azb7nie3.txt cache: ./cache/cord-001809-azb7nie3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001809-azb7nie3.txt' === file2bib.sh === id: cord-024461-xo75855r author: Zhang, Yuanzhe title: FCP Filter: A Dynamic Clustering-Prediction Framework for Customer Behavior date: 2020-04-17 pages: extension: .txt txt: ./txt/cord-024461-xo75855r.txt cache: ./cache/cord-024461-xo75855r.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-024461-xo75855r.txt' === file2bib.sh === id: cord-234996-hah19vmk author: Kabiri, Aliakbar title: How different age groups responded to the COVID-19 pandemic in terms of mobility behaviors: a case study of the United States date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-234996-hah19vmk.txt cache: ./cache/cord-234996-hah19vmk.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-234996-hah19vmk.txt' === file2bib.sh === id: cord-261163-n9tp9nx7 author: Ko, Jae-Hoon title: Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity date: 2017-10-31 pages: extension: .txt txt: ./txt/cord-261163-n9tp9nx7.txt cache: ./cache/cord-261163-n9tp9nx7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-261163-n9tp9nx7.txt' === file2bib.sh === id: cord-034714-6e37yylk author: Alleg, Manel title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML date: 2020-11-06 pages: extension: .txt txt: ./txt/cord-034714-6e37yylk.txt cache: ./cache/cord-034714-6e37yylk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-034714-6e37yylk.txt' === file2bib.sh === id: cord-030277-x9zvx3fp author: Ohta, Yoshinori title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial date: 2020-08-10 pages: extension: .txt txt: ./txt/cord-030277-x9zvx3fp.txt cache: ./cache/cord-030277-x9zvx3fp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-030277-x9zvx3fp.txt' === file2bib.sh === id: cord-024698-jrnw1i07 author: Hogan, Kevin title: Decidio: A Pilot Implementation and User Study of a Novel Decision-Support System date: 2020-04-25 pages: extension: .txt txt: ./txt/cord-024698-jrnw1i07.txt cache: ./cache/cord-024698-jrnw1i07.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-024698-jrnw1i07.txt' === file2bib.sh === id: cord-005379-5x4deimg author: Xu, Jing-Xiu title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels date: 2015-08-19 pages: extension: .txt txt: ./txt/cord-005379-5x4deimg.txt cache: ./cache/cord-005379-5x4deimg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-005379-5x4deimg.txt' === file2bib.sh === id: cord-009797-8mdie73v author: Valle, Denis title: Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change date: 2018-08-26 pages: extension: .txt txt: ./txt/cord-009797-8mdie73v.txt cache: ./cache/cord-009797-8mdie73v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009797-8mdie73v.txt' === file2bib.sh === id: cord-007580-qwh8ei60 author: Knopf, Harry L.S. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 pages: extension: .txt txt: ./txt/cord-007580-qwh8ei60.txt cache: ./cache/cord-007580-qwh8ei60.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-007580-qwh8ei60.txt' === file2bib.sh === id: cord-022643-2j559muh author: Chance, Gail D. title: SYSTEMATIC IMPLICATIONS OF SEED COAT MORPHOLOGY IN NAMA (HYDROPHYLLACEAE) date: 1984-07-01 pages: extension: .txt txt: ./txt/cord-022643-2j559muh.txt cache: ./cache/cord-022643-2j559muh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022643-2j559muh.txt' === file2bib.sh === id: cord-193497-qqrhvlm5 author: Shoghri, Ahmad El title: Identifying highly influential travellers for spreading disease on a public transport system date: 2020-04-03 pages: extension: .txt txt: ./txt/cord-193497-qqrhvlm5.txt cache: ./cache/cord-193497-qqrhvlm5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-193497-qqrhvlm5.txt' === file2bib.sh === id: cord-009962-k3opc553 author: Stjernquist‐Desatnik, Anna title: Pharyngotonsillitis date: 2008-12-17 pages: extension: .txt txt: ./txt/cord-009962-k3opc553.txt cache: ./cache/cord-009962-k3opc553.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-009962-k3opc553.txt' === file2bib.sh === id: cord-032657-1egdwe26 author: Gouda, Walaa title: COVID-19 disease: CT Pneumonia Analysis prototype by using artificial intelligence, predicting the disease severity date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-032657-1egdwe26.txt cache: ./cache/cord-032657-1egdwe26.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-032657-1egdwe26.txt' === file2bib.sh === id: cord-006987-1hf8vyhz author: Abass, Ahmed O title: Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults date: 2017-10-05 pages: extension: .txt txt: ./txt/cord-006987-1hf8vyhz.txt cache: ./cache/cord-006987-1hf8vyhz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006987-1hf8vyhz.txt' === file2bib.sh === id: cord-013263-xw611i8k author: Dederichs, Melina title: Students’ perspectives on interventions to reduce stress in medical school: A qualitative study date: 2020-10-15 pages: extension: .txt txt: ./txt/cord-013263-xw611i8k.txt cache: ./cache/cord-013263-xw611i8k.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-013263-xw611i8k.txt' === file2bib.sh === id: cord-003673-u7711eb4 author: Xiong, Xiao-Li title: Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile date: 2019-05-22 pages: extension: .txt txt: ./txt/cord-003673-u7711eb4.txt cache: ./cache/cord-003673-u7711eb4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003673-u7711eb4.txt' === file2bib.sh === id: cord-003825-tkqxb1ql author: Toman, Miroslav title: Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus date: 2019-08-06 pages: extension: .txt txt: ./txt/cord-003825-tkqxb1ql.txt cache: ./cache/cord-003825-tkqxb1ql.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-003825-tkqxb1ql.txt' === file2bib.sh === id: cord-022973-soaz8b74 author: Trivellini, Guido title: Nestedness of habitat specialists within habitat generalists in a butterfly assemblage date: 2016-09-25 pages: extension: .txt txt: ./txt/cord-022973-soaz8b74.txt cache: ./cache/cord-022973-soaz8b74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022973-soaz8b74.txt' === file2bib.sh === id: cord-032410-g546hez9 author: Hu, Yuan title: Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depression date: 2020-08-27 pages: extension: .txt txt: ./txt/cord-032410-g546hez9.txt cache: ./cache/cord-032410-g546hez9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-032410-g546hez9.txt' === file2bib.sh === id: cord-032979-jle66lmn author: ROMMEREIM, D. N. title: Reproduction, Growth, and Development of Rats during Chronic Exposure to Multiple Field Strengths of 60-Hz Electric Fields date: 1990-04-17 pages: extension: .txt txt: ./txt/cord-032979-jle66lmn.txt cache: ./cache/cord-032979-jle66lmn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-032979-jle66lmn.txt' === file2bib.sh === id: cord-264607-5vnaifi6 author: Chen, Wenyu title: A study on clinical effect of Arbidol combined with adjuvant therapy on COVID‐19 date: 2020-06-08 pages: extension: .txt txt: ./txt/cord-264607-5vnaifi6.txt cache: ./cache/cord-264607-5vnaifi6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-264607-5vnaifi6.txt' === file2bib.sh === id: cord-261073-s0qpiovr author: Ehrengut, W. title: A two year serological surveillance of coronavirus infections in Hamburg date: 1980 pages: extension: .txt txt: ./txt/cord-261073-s0qpiovr.txt cache: ./cache/cord-261073-s0qpiovr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261073-s0qpiovr.txt' === file2bib.sh === id: cord-006578-wv3wc0ct author: Stevens, D. L. title: Invasive streptococcal infections date: 2001 pages: extension: .txt txt: ./txt/cord-006578-wv3wc0ct.txt cache: ./cache/cord-006578-wv3wc0ct.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-006578-wv3wc0ct.txt' === file2bib.sh === id: cord-004091-gex0zvoa author: Abdulkareem, Shaheen A. title: Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date: 2020-01-06 pages: extension: .txt txt: ./txt/cord-004091-gex0zvoa.txt cache: ./cache/cord-004091-gex0zvoa.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004091-gex0zvoa.txt' === file2bib.sh === id: cord-013444-5aei9kaz author: Ruzauskas, Modestas title: The Influence of Essential Oils on Gut Microbial Profiles in Pigs date: 2020-09-24 pages: extension: .txt txt: ./txt/cord-013444-5aei9kaz.txt cache: ./cache/cord-013444-5aei9kaz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-013444-5aei9kaz.txt' === file2bib.sh === id: cord-006984-x1r99rlm author: Yokhana, J. S. title: Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry date: 2015-11-14 pages: extension: .txt txt: ./txt/cord-006984-x1r99rlm.txt cache: ./cache/cord-006984-x1r99rlm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-006984-x1r99rlm.txt' === file2bib.sh === id: cord-022879-j6cecioe author: Fager, Edward W. title: Determination and Analysis of Recurrent Groups date: 1957-10-01 pages: extension: .txt txt: ./txt/cord-022879-j6cecioe.txt cache: ./cache/cord-022879-j6cecioe.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-022879-j6cecioe.txt' === file2bib.sh === id: cord-026983-36n7bm3j author: Gillani, Syeda Shaista title: Synthesis, characterization and applications of poly-aliphatic amine dendrimers and dendrons date: 2020-06-17 pages: extension: .txt txt: ./txt/cord-026983-36n7bm3j.txt cache: ./cache/cord-026983-36n7bm3j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-026983-36n7bm3j.txt' === file2bib.sh === id: cord-271106-srym2kh4 author: De Rosa, Nicoletta title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study date: 2019-04-11 pages: extension: .txt txt: ./txt/cord-271106-srym2kh4.txt cache: ./cache/cord-271106-srym2kh4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-271106-srym2kh4.txt' === file2bib.sh === id: cord-260272-645g3to1 author: Haddad, Kevin title: COVID-19 implications on STEMI care date: 2020-09-19 pages: extension: .txt txt: ./txt/cord-260272-645g3to1.txt cache: ./cache/cord-260272-645g3to1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-260272-645g3to1.txt' === file2bib.sh === id: cord-011147-55whf8md author: Sun, Hengchang title: Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection date: 2020-01-07 pages: extension: .txt txt: ./txt/cord-011147-55whf8md.txt cache: ./cache/cord-011147-55whf8md.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-011147-55whf8md.txt' === file2bib.sh === id: cord-001236-cgiok0ce author: Binjawadagi, Basavaraj title: An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination date: 2014-03-24 pages: extension: .txt txt: ./txt/cord-001236-cgiok0ce.txt cache: ./cache/cord-001236-cgiok0ce.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-001236-cgiok0ce.txt' === file2bib.sh === id: cord-003913-jr9hj0bs author: Park, Hyeong-Jun title: Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant date: 2019-09-07 pages: extension: .txt txt: ./txt/cord-003913-jr9hj0bs.txt cache: ./cache/cord-003913-jr9hj0bs.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-003913-jr9hj0bs.txt' === file2bib.sh === id: cord-261380-xms5su6w author: Rahmani, Hamid title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-261380-xms5su6w.txt cache: ./cache/cord-261380-xms5su6w.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-261380-xms5su6w.txt' === file2bib.sh === id: cord-262716-hea84shy author: Pourali, Fatemeh title: Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis date: 2020-08-11 pages: extension: .txt txt: ./txt/cord-262716-hea84shy.txt cache: ./cache/cord-262716-hea84shy.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-262716-hea84shy.txt' === file2bib.sh === id: cord-239632-dyvhzvmm author: McGuigan, Michael title: Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning date: 2020-08-03 pages: extension: .txt txt: ./txt/cord-239632-dyvhzvmm.txt cache: ./cache/cord-239632-dyvhzvmm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-239632-dyvhzvmm.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 41796 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-004373-nmnssoeb author: Wall, Jonathan T. title: What about lay counselors’ experiences of task-shifting mental health interventions? Example from a family-based intervention in Kenya date: 2020-02-20 pages: extension: .txt txt: ./txt/cord-004373-nmnssoeb.txt cache: ./cache/cord-004373-nmnssoeb.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-004373-nmnssoeb.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 41517 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42100 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-266722-qfn2dc1q author: Wormser, Gary P. title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 pages: extension: .txt txt: ./txt/cord-266722-qfn2dc1q.txt cache: ./cache/cord-266722-qfn2dc1q.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-266722-qfn2dc1q.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42004 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-007367-e31zhty6 author: Tassier, Troy title: Network position and health care worker infections date: 2015-09-07 pages: extension: .txt txt: ./txt/cord-007367-e31zhty6.txt cache: ./cache/cord-007367-e31zhty6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-007367-e31zhty6.txt' === file2bib.sh === id: cord-274396-l611eisi author: Park, Su-Jin title: Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets date: 2020-05-22 pages: extension: .txt txt: ./txt/cord-274396-l611eisi.txt cache: ./cache/cord-274396-l611eisi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274396-l611eisi.txt' === file2bib.sh === id: cord-270210-gfy2ytg5 author: Drent, Marjolein title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-270210-gfy2ytg5.txt cache: ./cache/cord-270210-gfy2ytg5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270210-gfy2ytg5.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42322 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43017 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42820 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42868 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43059 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42869 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 42767 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43104 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43278 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-270998-1adloi3o author: Cunha, Rafes D. S. title: Comparison of immunity against canine distemper, adenovirus and parvovirus after vaccination with two multivalent canine vaccines date: 2020-04-27 pages: extension: .txt txt: ./txt/cord-270998-1adloi3o.txt cache: ./cache/cord-270998-1adloi3o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-270998-1adloi3o.txt' === file2bib.sh === id: cord-270727-2dd3b7di author: Rivera-Benitez, José Francisco title: Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus date: 2016-02-29 pages: extension: .txt txt: ./txt/cord-270727-2dd3b7di.txt cache: ./cache/cord-270727-2dd3b7di.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270727-2dd3b7di.txt' === file2bib.sh === id: cord-009969-ln91qfg4 author: Bertolesi, Gabriel E. title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl date: 2019-03-10 pages: extension: .txt txt: ./txt/cord-009969-ln91qfg4.txt cache: ./cache/cord-009969-ln91qfg4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009969-ln91qfg4.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43798 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43319 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 46150 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 45312 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 43945 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 45038 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-017067-19eawrjt author: Ogbondah, Chris Wolumati title: Terrorists and Social Media Messages: A Critical Analysis of Boko Haram’s Messages and Messaging Techniques date: 2017-10-24 pages: extension: .txt txt: ./txt/cord-017067-19eawrjt.txt cache: ./cache/cord-017067-19eawrjt.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-017067-19eawrjt.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 47084 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 45019 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 46000 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 32441 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 47360 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 48285 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 48238 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 49405 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 pages: extension: .txt txt: ./txt/cord-274563-jimw6skv.txt cache: ./cache/cord-274563-jimw6skv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274563-jimw6skv.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 49098 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 50546 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 pages: extension: .txt txt: ./txt/cord-274121-3w6kc0c9.txt cache: ./cache/cord-274121-3w6kc0c9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-274121-3w6kc0c9.txt' === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 50634 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-021419-nypnib0h author: Olsufyeva, Evgenia N. title: Main trends in the design of semi-synthetic antibiotics of a new generation date: 2020-03-17 pages: extension: .txt txt: ./txt/cord-021419-nypnib0h.txt cache: ./cache/cord-021419-nypnib0h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-021419-nypnib0h.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23146 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51287 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51288 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-274497-tqceazdp author: N. Nuñez, Luis Fabian title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 pages: extension: .txt txt: ./txt/cord-274497-tqceazdp.txt cache: ./cache/cord-274497-tqceazdp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-274497-tqceazdp.txt' === file2bib.sh === id: cord-275499-25dp6u68 author: Tan, Zhen title: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets date: 2019-12-30 pages: extension: .txt txt: ./txt/cord-275499-25dp6u68.txt cache: ./cache/cord-275499-25dp6u68.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-275499-25dp6u68.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52962 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-273839-oasgagpc author: Bisno, Alan L. title: Diagnosis and Management of Group A Streptococcal Pharyngitis: A Practice Guideline date: 1997-09-17 pages: extension: .txt txt: ./txt/cord-273839-oasgagpc.txt cache: ./cache/cord-273839-oasgagpc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-273839-oasgagpc.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51747 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 51826 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52852 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23443 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === /data-disk/reader-compute/reader-cord/bin/file2bib.sh: fork: retry: No child processes OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52726 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52166 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52231 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-023186-gqltd6u0 author: nan title: Poster Sessions date: 2019-06-27 pages: extension: .txt txt: ./txt/cord-023186-gqltd6u0.txt cache: ./cache/cord-023186-gqltd6u0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023186-gqltd6u0.txt' === file2bib.sh === id: cord-272497-ww9o1kjr author: Al-Anzi, Bader S. title: An Overview of the World Current and Future Assessment of Novel COVID-19 Trajectory, Impact, and Potential Preventive Strategies at Healthcare Settings date: 2020-09-25 pages: extension: .txt txt: ./txt/cord-272497-ww9o1kjr.txt cache: ./cache/cord-272497-ww9o1kjr.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-272497-ww9o1kjr.txt' === file2bib.sh === id: cord-305092-q4tlj1jd author: Lu, Jingjing title: Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China date: 2020-08-29 pages: extension: .txt txt: ./txt/cord-305092-q4tlj1jd.txt cache: ./cache/cord-305092-q4tlj1jd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-305092-q4tlj1jd.txt' === file2bib.sh === id: cord-285323-473d7zvg author: Jang, Hyesun title: Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus date: 2013-09-01 pages: extension: .txt txt: ./txt/cord-285323-473d7zvg.txt cache: ./cache/cord-285323-473d7zvg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-285323-473d7zvg.txt' === file2bib.sh === id: cord-023311-7wqdlha4 author: nan title: Oral Session date: 2010-11-24 pages: extension: .txt txt: ./txt/cord-023311-7wqdlha4.txt cache: ./cache/cord-023311-7wqdlha4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023311-7wqdlha4.txt' === file2bib.sh === id: cord-303378-cfbvka30 author: Zhang, Shi-Jin title: Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia date: 2013-08-31 pages: extension: .txt txt: ./txt/cord-303378-cfbvka30.txt cache: ./cache/cord-303378-cfbvka30.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-303378-cfbvka30.txt' === file2bib.sh === id: cord-301687-wadf3c3i author: Li, Yan title: Association of “initial CT” findings with mortality in older patients with coronavirus disease 2019 (COVID-19) date: 2020-06-10 pages: extension: .txt txt: ./txt/cord-301687-wadf3c3i.txt cache: ./cache/cord-301687-wadf3c3i.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-301687-wadf3c3i.txt' === file2bib.sh === id: cord-299691-jton1oig author: Jové-Blanco, A. title: Video discharge instructions for pediatric gastroenteritis in an emergency department: a randomized, controlled trial date: 2020-10-08 pages: extension: .txt txt: ./txt/cord-299691-jton1oig.txt cache: ./cache/cord-299691-jton1oig.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-299691-jton1oig.txt' === file2bib.sh === id: cord-286779-si3qml42 author: Li, Hai-yan title: Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-286779-si3qml42.txt cache: ./cache/cord-286779-si3qml42.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-286779-si3qml42.txt' === file2bib.sh === id: cord-296606-aizjzglo author: Guo, Tingting title: Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients date: 2020-07-30 pages: extension: .txt txt: ./txt/cord-296606-aizjzglo.txt cache: ./cache/cord-296606-aizjzglo.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-296606-aizjzglo.txt' === file2bib.sh === id: cord-298534-1j8jkfn9 author: Zhu, H. title: Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study date: 2020-11-03 pages: extension: .txt txt: ./txt/cord-298534-1j8jkfn9.txt cache: ./cache/cord-298534-1j8jkfn9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-298534-1j8jkfn9.txt' === file2bib.sh === id: cord-312497-6cd7dolj author: Mishra, Anurag title: Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Low- to Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study date: 2020-08-19 pages: extension: .txt txt: ./txt/cord-312497-6cd7dolj.txt cache: ./cache/cord-312497-6cd7dolj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312497-6cd7dolj.txt' === file2bib.sh === id: cord-329669-z3t7plvh author: Poulton, Kay title: A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients date: 2020-07-05 pages: extension: .txt txt: ./txt/cord-329669-z3t7plvh.txt cache: ./cache/cord-329669-z3t7plvh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329669-z3t7plvh.txt' === file2bib.sh === id: cord-302079-pby3i6wq author: Deng, Yan title: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-302079-pby3i6wq.txt cache: ./cache/cord-302079-pby3i6wq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302079-pby3i6wq.txt' === file2bib.sh === id: cord-280036-ev82fzly author: Almawly, J. title: Utility of halofuginone lactate for the prevention of natural cryptosporidiosis of calves, in the presence of co-infection with rotavirus and Salmonella Typhimurium date: 2013-10-18 pages: extension: .txt txt: ./txt/cord-280036-ev82fzly.txt cache: ./cache/cord-280036-ev82fzly.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-280036-ev82fzly.txt' === file2bib.sh === id: cord-302695-vyo3w2a4 author: Albertini, Laetitia title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 pages: extension: .txt txt: ./txt/cord-302695-vyo3w2a4.txt cache: ./cache/cord-302695-vyo3w2a4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-302695-vyo3w2a4.txt' === file2bib.sh === id: cord-337644-aobdzwpx author: Pianta, L. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 pages: extension: .txt txt: ./txt/cord-337644-aobdzwpx.txt cache: ./cache/cord-337644-aobdzwpx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-337644-aobdzwpx.txt' === file2bib.sh === id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 pages: extension: .txt txt: ./txt/cord-016559-tqd7m2i1.txt cache: ./cache/cord-016559-tqd7m2i1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-016559-tqd7m2i1.txt' === file2bib.sh === id: cord-326747-zwp13awk author: Sever, Mustafa title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 pages: extension: .txt txt: ./txt/cord-326747-zwp13awk.txt cache: ./cache/cord-326747-zwp13awk.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-326747-zwp13awk.txt' === file2bib.sh === id: cord-341397-gl8xzzdv author: Bhavani, Sivasubramanium V. title: Novel Temperature Trajectory Subphenotypes in COVID-19 date: 2020-07-21 pages: extension: .txt txt: ./txt/cord-341397-gl8xzzdv.txt cache: ./cache/cord-341397-gl8xzzdv.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-341397-gl8xzzdv.txt' === file2bib.sh === id: cord-303807-fka9svzu author: Gerber, Michael A. title: Diagnosis and Treatment of Pharyngitis in Children date: 2005-05-28 pages: extension: .txt txt: ./txt/cord-303807-fka9svzu.txt cache: ./cache/cord-303807-fka9svzu.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-303807-fka9svzu.txt' === file2bib.sh === id: cord-329856-0m5mc320 author: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 pages: extension: .txt txt: ./txt/cord-329856-0m5mc320.txt cache: ./cache/cord-329856-0m5mc320.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-329856-0m5mc320.txt' === file2bib.sh === id: cord-300046-orlga9qf author: Gomes da Silva, J. title: Health literacy of inland population in the mitigation phase 3.2. of COVID-19's pandemic in Portugal - a descriptive cohort study date: 2020-05-14 pages: extension: .txt txt: ./txt/cord-300046-orlga9qf.txt cache: ./cache/cord-300046-orlga9qf.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-300046-orlga9qf.txt' === file2bib.sh === id: cord-333745-nwnt2tde author: Wang, Yi title: Clinical characteristics and laboratory indicator analysis of 67 COVID-19 pneumonia patients in Suzhou, China date: 2020-10-12 pages: extension: .txt txt: ./txt/cord-333745-nwnt2tde.txt cache: ./cache/cord-333745-nwnt2tde.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333745-nwnt2tde.txt' === file2bib.sh === id: cord-333334-90q1xkld author: Shengchen, D. title: Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial date: 2019-06-20 pages: extension: .txt txt: ./txt/cord-333334-90q1xkld.txt cache: ./cache/cord-333334-90q1xkld.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-333334-90q1xkld.txt' === file2bib.sh === id: cord-342391-arp07mck author: Magiorkinis, G. title: Phylogenetic analysis of the full‐length SARS‐CoV sequences: Evidence for phylogenetic discordance in three genomic regions date: 2004-09-14 pages: extension: .txt txt: ./txt/cord-342391-arp07mck.txt cache: ./cache/cord-342391-arp07mck.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342391-arp07mck.txt' === file2bib.sh === id: cord-317347-by8albr9 author: van Ginkel, Frederik W. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 pages: extension: .txt txt: ./txt/cord-317347-by8albr9.txt cache: ./cache/cord-317347-by8albr9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-317347-by8albr9.txt' === file2bib.sh === id: cord-336192-5uxq5xrs author: Alavi, Maryam title: Coordination, cooperation, and creativity within harm reduction networks in Iran: COVID-19 prevention and control among people who use drugs date: 2020-08-17 pages: extension: .txt txt: ./txt/cord-336192-5uxq5xrs.txt cache: ./cache/cord-336192-5uxq5xrs.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336192-5uxq5xrs.txt' === file2bib.sh === id: cord-343418-519vkzci author: Li, Hao title: Study on the Performance Degradation of Sandstone under Acidification date: 2020-10-21 pages: extension: .txt txt: ./txt/cord-343418-519vkzci.txt cache: ./cache/cord-343418-519vkzci.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-343418-519vkzci.txt' === file2bib.sh === id: cord-348785-f67amppy author: Kapicibaşi, Hasan Oğuz title: Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model date: 2020-07-13 pages: extension: .txt txt: ./txt/cord-348785-f67amppy.txt cache: ./cache/cord-348785-f67amppy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-348785-f67amppy.txt' === file2bib.sh === id: cord-312695-1uw8xcxw author: Sugiarto, Sarah title: Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis date: 2016-08-05 pages: extension: .txt txt: ./txt/cord-312695-1uw8xcxw.txt cache: ./cache/cord-312695-1uw8xcxw.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-312695-1uw8xcxw.txt' === file2bib.sh === id: cord-353256-7nfklun9 author: Eroglu‐Ertugrul, Nesibe Gevher title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 pages: extension: .txt txt: ./txt/cord-353256-7nfklun9.txt cache: ./cache/cord-353256-7nfklun9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-353256-7nfklun9.txt' === file2bib.sh === id: cord-326723-jiauk4fq author: Risalde, María A title: Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1 date: 2013-03-18 pages: extension: .txt txt: ./txt/cord-326723-jiauk4fq.txt cache: ./cache/cord-326723-jiauk4fq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-326723-jiauk4fq.txt' === file2bib.sh === id: cord-324326-q014b5ym author: MURAKAMI, Makoto title: Lipoquality control by phospholipase A(2) enzymes date: 2017-11-10 pages: extension: .txt txt: ./txt/cord-324326-q014b5ym.txt cache: ./cache/cord-324326-q014b5ym.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-324326-q014b5ym.txt' === file2bib.sh === id: cord-332735-vfnbs2jn author: Rebmann, Terri title: Infection preventionists' experience during the first months of the 2009 novel H1N1 influenza A pandemic date: 2009-12-31 pages: extension: .txt txt: ./txt/cord-332735-vfnbs2jn.txt cache: ./cache/cord-332735-vfnbs2jn.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-332735-vfnbs2jn.txt' === file2bib.sh === id: cord-304208-jwlc8fxj author: Vagni, Monia title: Coping With COVID-19: Emergency Stress, Secondary Trauma and Self-Efficacy in Healthcare and Emergency Workers in Italy date: 2020-09-03 pages: extension: .txt txt: ./txt/cord-304208-jwlc8fxj.txt cache: ./cache/cord-304208-jwlc8fxj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-304208-jwlc8fxj.txt' === file2bib.sh === id: cord-342210-r8vxz5vu author: Mukherjee, Pranab K. title: Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections date: 2017-01-14 pages: extension: .txt txt: ./txt/cord-342210-r8vxz5vu.txt cache: ./cache/cord-342210-r8vxz5vu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-342210-r8vxz5vu.txt' === file2bib.sh === id: cord-331270-12zx0o2p author: Rico, Timóteo Matthies title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 pages: extension: .txt txt: ./txt/cord-331270-12zx0o2p.txt cache: ./cache/cord-331270-12zx0o2p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-331270-12zx0o2p.txt' === file2bib.sh === id: cord-355190-ytdw1d5v author: Mok, Chi Chiu title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 pages: extension: .txt txt: ./txt/cord-355190-ytdw1d5v.txt cache: ./cache/cord-355190-ytdw1d5v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-355190-ytdw1d5v.txt' === file2bib.sh === id: cord-347960-vl5zhxyh author: Giallonardo, Vincenzo title: The Impact of Quarantine and Physical Distancing Following COVID-19 on Mental Health: Study Protocol of a Multicentric Italian Population Trial date: 2020-06-05 pages: extension: .txt txt: ./txt/cord-347960-vl5zhxyh.txt cache: ./cache/cord-347960-vl5zhxyh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-347960-vl5zhxyh.txt' === file2bib.sh === id: cord-344121-k58c0jf3 author: Lundgren, A.-L. title: Neurological disease and encephalitis in cats experimentally infected with Borna disease virus date: 1997 pages: extension: .txt txt: ./txt/cord-344121-k58c0jf3.txt cache: ./cache/cord-344121-k58c0jf3.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-344121-k58c0jf3.txt' === file2bib.sh === id: cord-302305-xr067v2n author: van Aalst, Jan title: Distinguishing knowledge-sharing, knowledge-construction, and knowledge-creation discourses date: 2009-06-20 pages: extension: .txt txt: ./txt/cord-302305-xr067v2n.txt cache: ./cache/cord-302305-xr067v2n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-302305-xr067v2n.txt' === file2bib.sh === id: cord-344411-lkgcxjya author: Huang, Qiqi title: The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens date: 2017-06-01 pages: extension: .txt txt: ./txt/cord-344411-lkgcxjya.txt cache: ./cache/cord-344411-lkgcxjya.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-344411-lkgcxjya.txt' === file2bib.sh === id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 pages: extension: .txt txt: ./txt/cord-015082-l629n8is.txt cache: ./cache/cord-015082-l629n8is.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015082-l629n8is.txt' === file2bib.sh === id: cord-342381-i63r6los author: Wu, Huiyue title: Design and development of an immersive virtual reality news application: a case study of the SARS event date: 2020-09-17 pages: extension: .txt txt: ./txt/cord-342381-i63r6los.txt cache: ./cache/cord-342381-i63r6los.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-342381-i63r6los.txt' === file2bib.sh === id: cord-014670-e31g8lns author: nan title: Poster Sessions 313-503 date: 2004-10-05 pages: extension: .txt txt: ./txt/cord-014670-e31g8lns.txt cache: ./cache/cord-014670-e31g8lns.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-014670-e31g8lns.txt' === file2bib.sh === id: cord-023134-y665agnh author: nan title: Oral Research Communications of the 22(nd) ECVIM‐CA Congress date: 2012-11-20 pages: extension: .txt txt: ./txt/cord-023134-y665agnh.txt cache: ./cache/cord-023134-y665agnh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-023134-y665agnh.txt' === file2bib.sh === id: cord-349720-2lxab3u2 author: Qin, Ling title: Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits date: 2015-05-15 pages: extension: .txt txt: ./txt/cord-349720-2lxab3u2.txt cache: ./cache/cord-349720-2lxab3u2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-349720-2lxab3u2.txt' === file2bib.sh === id: cord-012518-ncrdwtdg author: nan title: Abstractband DOG 2020 date: 2020-08-24 pages: extension: .txt txt: ./txt/cord-012518-ncrdwtdg.txt cache: ./cache/cord-012518-ncrdwtdg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-012518-ncrdwtdg.txt' === file2bib.sh === id: cord-339705-x8l3zgfd author: Patil, Vijaykumar title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 pages: extension: .txt txt: ./txt/cord-339705-x8l3zgfd.txt cache: ./cache/cord-339705-x8l3zgfd.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-339705-x8l3zgfd.txt' === file2bib.sh === id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 pages: extension: .txt txt: ./txt/cord-317344-wznzmssz.txt cache: ./cache/cord-317344-wznzmssz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-317344-wznzmssz.txt' === file2bib.sh === id: cord-015372-76xvzvdg author: nan title: National scientific medical meeting 1996 abstracts date: 1996 pages: extension: .txt txt: ./txt/cord-015372-76xvzvdg.txt cache: ./cache/cord-015372-76xvzvdg.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-015372-76xvzvdg.txt' === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 23485 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 25643 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-014516-r59usk02 author: nan title: Research Communications of the 24th ECVIM‐CA Congress date: 2015-01-10 pages: extension: .txt txt: ./txt/cord-014516-r59usk02.txt cache: ./cache/cord-014516-r59usk02.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-014516-r59usk02.txt' === file2bib.sh === id: cord-022653-qa1uph35 author: nan title: Poster Discussion Session PDS date: 2017-08-30 pages: extension: .txt txt: ./txt/cord-022653-qa1uph35.txt cache: ./cache/cord-022653-qa1uph35.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-022653-qa1uph35.txt' === file2bib.sh === id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 pages: extension: .txt txt: ./txt/cord-014538-6a2pviol.txt cache: ./cache/cord-014538-6a2pviol.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-014538-6a2pviol.txt' === file2bib.sh === id: cord-295987-die9jmbv author: Chabre, Yoann M. title: Design and Creativity in Synthesis of Multivalent Neoglycoconjugates date: 2010-04-08 pages: extension: .txt txt: ./txt/cord-295987-die9jmbv.txt cache: ./cache/cord-295987-die9jmbv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-295987-die9jmbv.txt' === file2bib.sh === id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 pages: extension: .txt txt: ./txt/cord-023017-k6edtg58.txt cache: ./cache/cord-023017-k6edtg58.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023017-k6edtg58.txt' === file2bib.sh === id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 pages: extension: .txt txt: ./txt/cord-005777-6rvfsx4p.txt cache: ./cache/cord-005777-6rvfsx4p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-005777-6rvfsx4p.txt' === file2bib.sh === id: cord-015126-cyhcbk1j author: nan title: PS 0036-0344 date: 2007-08-25 pages: extension: .txt txt: ./txt/cord-015126-cyhcbk1j.txt cache: ./cache/cord-015126-cyhcbk1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-015126-cyhcbk1j.txt' === file2bib.sh === id: cord-023225-5quigar4 author: nan title: Posters date: 2012-08-21 pages: extension: .txt txt: ./txt/cord-023225-5quigar4.txt cache: ./cache/cord-023225-5quigar4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-023225-5quigar4.txt' === file2bib.sh === id: cord-014527-nvzfpntu author: nan title: Research Communications of the 25th ECVIM‐CA Congress date: 2015-11-09 pages: extension: .txt txt: ./txt/cord-014527-nvzfpntu.txt cache: ./cache/cord-014527-nvzfpntu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-014527-nvzfpntu.txt' === file2bib.sh === id: cord-005881-oswgjaxz author: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 pages: extension: .txt txt: ./txt/cord-005881-oswgjaxz.txt cache: ./cache/cord-005881-oswgjaxz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-005881-oswgjaxz.txt' === file2bib.sh === id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 pages: extension: .txt txt: ./txt/cord-003532-lcgeingz.txt cache: ./cache/cord-003532-lcgeingz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-003532-lcgeingz.txt' === file2bib.sh === id: cord-002774-tpqsjjet author: nan title: Section II: Poster Sessions date: 2017-12-01 pages: extension: .txt txt: ./txt/cord-002774-tpqsjjet.txt cache: ./cache/cord-002774-tpqsjjet.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-002774-tpqsjjet.txt' === file2bib.sh === id: cord-014996-p6q0f37c author: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 pages: extension: .txt txt: ./txt/cord-014996-p6q0f37c.txt cache: ./cache/cord-014996-p6q0f37c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-014996-p6q0f37c.txt' === file2bib.sh === id: cord-015368-a0qz4tb9 author: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 pages: extension: .txt txt: ./txt/cord-015368-a0qz4tb9.txt cache: ./cache/cord-015368-a0qz4tb9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-015368-a0qz4tb9.txt' === file2bib.sh === id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-015024-2xzc0uc5.txt cache: ./cache/cord-015024-2xzc0uc5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-015024-2xzc0uc5.txt' === file2bib.sh === id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 pages: extension: .txt txt: ./txt/cord-005816-i54q5gsu.txt cache: ./cache/cord-005816-i54q5gsu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-005816-i54q5gsu.txt' === file2bib.sh === id: cord-011062-ukz4hnmy author: nan title: Poster date: 2020-03-11 pages: extension: .txt txt: ./txt/cord-011062-ukz4hnmy.txt cache: ./cache/cord-011062-ukz4hnmy.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-011062-ukz4hnmy.txt' === file2bib.sh === id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 pages: extension: .txt txt: ./txt/cord-014533-6qfecv5h.txt cache: ./cache/cord-014533-6qfecv5h.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-014533-6qfecv5h.txt' === file2bib.sh === id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 pages: extension: .txt txt: ./txt/cord-335975-m6lkrehi.txt cache: ./cache/cord-335975-m6lkrehi.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-335975-m6lkrehi.txt' === file2bib.sh === id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 pages: extension: .txt txt: ./txt/cord-005727-li8pwigg.txt cache: ./cache/cord-005727-li8pwigg.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-005727-li8pwigg.txt' === file2bib.sh === id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 pages: extension: .txt txt: ./txt/cord-014464-m5n250r2.txt cache: ./cache/cord-014464-m5n250r2.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 17 resourceName b'cord-014464-m5n250r2.txt' === file2bib.sh === id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 pages: extension: .txt txt: ./txt/cord-005497-w81ysjf9.txt cache: ./cache/cord-005497-w81ysjf9.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-005497-w81ysjf9.txt' === file2bib.sh === id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 pages: extension: .txt txt: ./txt/cord-355038-o2hr5mox.txt cache: ./cache/cord-355038-o2hr5mox.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-355038-o2hr5mox.txt' === file2bib.sh === id: cord-019347-tj3ye1mx author: nan title: ABSTRACT BOOK date: 2010-02-19 pages: extension: .txt txt: ./txt/cord-019347-tj3ye1mx.txt cache: ./cache/cord-019347-tj3ye1mx.txt Content-Encoding ISO-8859-1 Content-Type text/plain; charset=ISO-8859-1 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 7 resourceName b'cord-019347-tj3ye1mx.txt' === file2bib.sh === id: cord-000083-3p81yr4n author: nan title: Poster Exhibition date: 2009-01-31 pages: extension: .txt txt: ./txt/cord-000083-3p81yr4n.txt cache: ./cache/cord-000083-3p81yr4n.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-000083-3p81yr4n.txt' === file2bib.sh === id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 pages: extension: .txt txt: ./txt/cord-341063-3rqnu5bu.txt cache: ./cache/cord-341063-3rqnu5bu.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 8 resourceName b'cord-341063-3rqnu5bu.txt' === file2bib.sh === id: cord-023354-f2ciho6o author: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023354-f2ciho6o.txt cache: ./cache/cord-023354-f2ciho6o.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-023354-f2ciho6o.txt' === file2bib.sh === id: cord-005105-twsy61oq author: nan title: SIU 2015 Abstracts date: 2015-09-21 pages: extension: .txt txt: ./txt/cord-005105-twsy61oq.txt cache: ./cache/cord-005105-twsy61oq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 20 resourceName b'cord-005105-twsy61oq.txt' === file2bib.sh === id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 pages: extension: .txt txt: ./txt/cord-022650-phsr10jp.txt cache: ./cache/cord-022650-phsr10jp.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 22 resourceName b'cord-022650-phsr10jp.txt' === file2bib.sh === id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 pages: extension: .txt txt: ./txt/cord-023157-0lqlx2rv.txt cache: ./cache/cord-023157-0lqlx2rv.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 10 resourceName b'cord-023157-0lqlx2rv.txt' === file2bib.sh === id: cord-023364-ut56gczm author: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023364-ut56gczm.txt cache: ./cache/cord-023364-ut56gczm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-023364-ut56gczm.txt' === file2bib.sh === id: cord-023346-8sqbqjm1 author: nan title: MONDAY: POSTERS date: 2005-06-08 pages: extension: .txt txt: ./txt/cord-023346-8sqbqjm1.txt cache: ./cache/cord-023346-8sqbqjm1.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 23 resourceName b'cord-023346-8sqbqjm1.txt' === file2bib.sh === id: cord-009567-osstpum6 author: nan title: Abstracts Oral date: 2008-04-23 pages: extension: .txt txt: ./txt/cord-009567-osstpum6.txt cache: ./cache/cord-009567-osstpum6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-009567-osstpum6.txt' === file2bib.sh === id: cord-023095-4dannjjm author: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 pages: extension: .txt txt: ./txt/cord-023095-4dannjjm.txt cache: ./cache/cord-023095-4dannjjm.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-023095-4dannjjm.txt' === file2bib.sh === id: cord-000977-ka4261wc author: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 pages: extension: .txt txt: ./txt/cord-000977-ka4261wc.txt cache: ./cache/cord-000977-ka4261wc.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 19 resourceName b'cord-000977-ka4261wc.txt' === file2bib.sh === id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 pages: extension: .txt txt: ./txt/cord-022633-fr55uod6.txt cache: ./cache/cord-022633-fr55uod6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-022633-fr55uod6.txt' === file2bib.sh === id: cord-010980-sizuef1v author: nan title: ECTES Abstracts 2020 date: 2020-05-11 pages: extension: .txt txt: ./txt/cord-010980-sizuef1v.txt cache: ./cache/cord-010980-sizuef1v.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 12 resourceName b'cord-010980-sizuef1v.txt' === file2bib.sh === id: cord-014794-yppi30a0 author: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 pages: extension: .txt txt: ./txt/cord-014794-yppi30a0.txt cache: ./cache/cord-014794-yppi30a0.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 9 resourceName b'cord-014794-yppi30a0.txt' === file2bib.sh === id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 pages: extension: .txt txt: ./txt/cord-015021-pol2qm74.txt cache: ./cache/cord-015021-pol2qm74.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 11 resourceName b'cord-015021-pol2qm74.txt' === file2bib.sh === id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 pages: extension: .txt txt: ./txt/cord-005814-ak5pq312.txt cache: ./cache/cord-005814-ak5pq312.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 23 resourceName b'cord-005814-ak5pq312.txt' === file2bib.sh === id: cord-006854-o2e5na78 author: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 pages: extension: .txt txt: ./txt/cord-006854-o2e5na78.txt cache: ./cache/cord-006854-o2e5na78.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 13 resourceName b'cord-006854-o2e5na78.txt' === file2bib.sh === id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 pages: extension: .txt txt: ./txt/cord-009997-oecpqf1j.txt cache: ./cache/cord-009997-oecpqf1j.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 14 resourceName b'cord-009997-oecpqf1j.txt' === file2bib.sh === id: cord-015324-y44sfr0c author: nan title: Scientific Programme date: 2007-09-01 pages: extension: .txt txt: ./txt/cord-015324-y44sfr0c.txt cache: ./cache/cord-015324-y44sfr0c.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 17 resourceName b'cord-015324-y44sfr0c.txt' === file2bib.sh === id: cord-010092-uftc8inx author: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 pages: extension: .txt txt: ./txt/cord-010092-uftc8inx.txt cache: ./cache/cord-010092-uftc8inx.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 26 resourceName b'cord-010092-uftc8inx.txt' === file2bib.sh === id: cord-015354-yknwveyz author: nan title: Abstracts_Poster presentations date: 2007-09-18 pages: extension: .txt txt: ./txt/cord-015354-yknwveyz.txt cache: ./cache/cord-015354-yknwveyz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 16 resourceName b'cord-015354-yknwveyz.txt' === file2bib.sh === id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 pages: extension: .txt txt: ./txt/cord-006849-vgjz74ts.txt cache: ./cache/cord-006849-vgjz74ts.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 15 resourceName b'cord-006849-vgjz74ts.txt' === file2bib.sh === id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 pages: extension: .txt txt: ./txt/cord-022940-atbjwpo5.txt cache: ./cache/cord-022940-atbjwpo5.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 31 resourceName b'cord-022940-atbjwpo5.txt' === file2bib.sh === id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 pages: extension: .txt txt: ./txt/cord-005453-4057qib7.txt cache: ./cache/cord-005453-4057qib7.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 52 resourceName b'cord-005453-4057qib7.txt' Que is empty; done keyword-group-cord === reduce.pl bib === id = cord-004091-gex0zvoa author = Abdulkareem, Shaheen A. title = Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date = 2020-01-06 pages = extension = .txt mime = text/plain words = 8379 sentences = 432 flesch = 50 summary = For this study, we ran eight ABMs to test various combinations of individual and group learning, using different information sources-with or without interactions among agents-as factors in the BNs. We investigate the extent to which the epidemic spreads, depending on these different learning approaches regarding risk perception and coping decisions. The empirically-driven BNs model a two-stage decision process of people facing a disease risk: learning to update risk perceptions (threat appraisal, BN1 in Fig 1) and making decisions about how to adapt their behavior during the epidemic (coping appraisal, BN2 in Fig 1) . To evaluate the impact of individual and social intelligence on agents' learning processes regarding risk perception and coping appraisal and the resulting patterns of disease spread, we used four output measures: disease diffusion, risk perception, spatial patterns, and model performance. Finally, in M7, where household agents learned risk perception in decentralized groups and learned to cope individually, 2,911 infected cases were recorded (Table 3) . cache = ./cache/cord-004091-gex0zvoa.txt txt = ./txt/cord-004091-gex0zvoa.txt === reduce.pl bib === id = cord-003825-tkqxb1ql author = Toman, Miroslav title = Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus date = 2019-08-06 pages = extension = .txt mime = text/plain words = 6723 sentences = 395 flesch = 49 summary = The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. Comparison of serum and oral fluid antibody responses after vaccination with modified live (MLV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in PRRS endemic farms cache = ./cache/cord-003825-tkqxb1ql.txt txt = ./txt/cord-003825-tkqxb1ql.txt === reduce.pl bib === id = cord-001236-cgiok0ce author = Binjawadagi, Basavaraj title = An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination date = 2014-03-24 pages = extension = .txt mime = text/plain words = 7565 sentences = 389 flesch = 47 summary = title: An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination Therefore, we attempted to strengthen the immunogenicity of inactivated/killed PRRSV vaccine antigens (KAg), especially in the pig respiratory system, through: 1) entrapping the KAg in biodegradable poly(lactic-co-glycolic acid) nanoparticles (NP-KAg); 2) coupling the NP-KAg with a potent mucosal adjuvant, whole cell lysate of Mycobacterium tuberculosis (M. 32 In adjuvanted NP-KAgvaccinated pigs, increased avidity of virus-specific IgA was detected in both BAL fluid (both low and high doses) and lung homogenate (only low dose) samples compared to other tested groups (Figure 2A-C) . Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs cache = ./cache/cord-001236-cgiok0ce.txt txt = ./txt/cord-001236-cgiok0ce.txt === reduce.pl bib === id = cord-003913-jr9hj0bs author = Park, Hyeong-Jun title = Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant date = 2019-09-07 pages = extension = .txt mime = text/plain words = 7537 sentences = 429 flesch = 53 summary = Furthermore, poly I:C induced higher pro-inflammatory cytokines than those of ssRNA nanostructure adjuvant in RAW 264.7 cells, which are a mouse macrophage cell line ( Figure S3 , detailed in supplementary methods), indicating poly I:C may stimulate a stronger inflammation response compared to that of the ssRNA nano-structure adjuvant. Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ). Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ). cache = ./cache/cord-003913-jr9hj0bs.txt txt = ./txt/cord-003913-jr9hj0bs.txt === reduce.pl bib === id = cord-004373-nmnssoeb author = Wall, Jonathan T. title = What about lay counselors’ experiences of task-shifting mental health interventions? Example from a family-based intervention in Kenya date = 2020-02-20 pages = extension = .txt mime = text/plain words = 9305 sentences = 436 flesch = 46 summary = We aimed to describe how lay counselors experience role shifts and associated outcomes, such as Keywords: Mental health, Lay counselors, Task shifting, Africa, Burnout, Motivation, Self-efficacy, Stress, Family therapy, Children Intrinsic and extrinsic forces, beliefs, and ideals that incline an individual to pursue and maintain their position as a lay counselor [22] An individual's perceptions and assessments of their capability to be competent and effective in their counseling role [23] The physical, psychological, emotional, and social consequences that affect a lay counselor due to trying to fulfill the duties and responsibilities expected of them by their clients, supervisors, and communities Because the intervention was designed with the goal of minimizing the added burden for lay providers (described below), it offers a helpful lens and case study for understanding the specific contribution of role shifts in relation to other stressors associated with lay counselor experiences. cache = ./cache/cord-004373-nmnssoeb.txt txt = ./txt/cord-004373-nmnssoeb.txt === reduce.pl bib === id = cord-003024-17f1evh3 author = Nunes, Márcio Roberto Teixeira title = Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas date = 2018-05-24 pages = extension = .txt mime = text/plain words = 3449 sentences = 166 flesch = 47 summary = Maximum likelihood (ML) phylogenetic trees were constructed using nucleotide and amino acids sequences of viruses reported in our study and additional sequences of members of Group C viruses with complete coding sequences (S, M, and L) available in the GenBank database (http://www.ncbi.nlm.nih.gov/) until 10 th of April of 2018. Our results showed that the complete SRNA segments of Group C viruses ranged from 1,003 to 1,111 nucleotides (nt) and presents the open reading frame (ORF) of the nucleocapsid (N) protein, with a conserved size of 235 amino acids (aa) and 26.72 to 27.03 kDa for all viruses (Fig 1) . To better understand the genetic relationships among group C viruses, we conducted the ML trees based on the complete coding sequences in nucleotide and amino acids level for all segments (Fig 3 and S1 Fig) . cache = ./cache/cord-003024-17f1evh3.txt txt = ./txt/cord-003024-17f1evh3.txt === reduce.pl bib === id = cord-006578-wv3wc0ct author = Stevens, D. L. title = Invasive streptococcal infections date = 2001 pages = extension = .txt mime = text/plain words = 8839 sentences = 531 flesch = 45 summary = The risk for secondary cases is likely related to close or intimate contact and crowding, as well as host factors such as: (1) active viral infections such as varicella or influenza; (2) recent surgical wounds and childbirth (author's unpublished observations); (3) absence of type specific opsonic antibody against the group A streptococcus causing the index case; and (4) absence of neutralizing antibody against pyrogenic exotoxin A or B. 17 Streptococcal pyrogenic exotoxins A and B induce human mononuclear cells to synthesize not only TNFα 75 but also IL-1 76 and IL-6, [76] [77] [78] suggesting that TNF could mediate the fever, shock, and organ failure observed in patients with StrepTSS. Multi-locus enzyme electrophoresis demonstrates two patterns, which correspond to M-1 and M-3 type organisms that produce pyrogenic exotoxin A, a finding that fits epidemiologic studies implicating these strains in invasive group A streptococcal infections 54 in the United States. cache = ./cache/cord-006578-wv3wc0ct.txt txt = ./txt/cord-006578-wv3wc0ct.txt === reduce.pl bib === id = cord-002774-tpqsjjet author = nan title = Section II: Poster Sessions date = 2017-12-01 pages = extension = .txt mime = text/plain words = 83515 sentences = 5162 flesch = 54 summary = Results: The CHIP Framework The CHIP framework aims to improve the health and wellness of the urban communities served by St. Josephs Health Centre through four intersecting pillars: • Raising Community Voices provides an infrastructure and process that supports community stakeholder input into health care service planning, decision-making, and delivery by the hospital and across the continuum of care; • Sharing Reciprocal Capacity promotes healthy communities through the sharing of our intellectual and physical capacity with our community partners; • Cultivating Integration Initiatives facilitates vertical, horizontal, and intersectoral integration initiatives in support of community-identified needs and gaps; and • Facilitating Healthy Exchange develops best practices in community integration through community-based research, and facilitates community voice in informing public policy. cache = ./cache/cord-002774-tpqsjjet.txt txt = ./txt/cord-002774-tpqsjjet.txt === reduce.pl bib === id = cord-009797-8mdie73v author = Valle, Denis title = Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change date = 2018-08-26 pages = extension = .txt mime = text/plain words = 5624 sentences = 244 flesch = 50 summary = title: Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change The Latent Dirichlet Allocation (LDA) model is a mixed‐membership method that can represent gradual changes in community structure by delineating overlapping groups of species, but its use has been limited because it requires abundance data and requires users to a priori set the number of groups. Furthermore, by comparing the estimated proportion of each group for two time periods (1997–2002 and 2010–2015), our results indicate that nine (of 18) breeding bird groups exhibited an expansion northward and contraction southward of their ranges, revealing subtle but important community‐level biodiversity changes at a continental scale that are consistent with those expected under climate change. It is important to note that even in the absence of MM sampling units, LDA can still estimate well the true number of groups and has similar fit to the data as the other clustering approaches (results not shown). cache = ./cache/cord-009797-8mdie73v.txt txt = ./txt/cord-009797-8mdie73v.txt === reduce.pl bib === id = cord-005379-5x4deimg author = Xu, Jing-Xiu title = Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels date = 2015-08-19 pages = extension = .txt mime = text/plain words = 5602 sentences = 342 flesch = 48 summary = title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels To determine dietary selenium (Se) status regulates the transcriptions of selenoproteome and activities of selenoenzymes in chicken kidney, 1-day-old chickens received low Se (0.028 mg Se per kg of diet) or super-nutritional Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. Low Se significantly reduced total antioxidant capability (T-AOC), glutathione (GSH) content, but malondialdehyde (MDA) content in the kidney increased and decreased glutathione peroxidase (Gpx) and thioredoxin reductase (TrxR) activity with changes in their mRNA levels. Se could protect the renal antioxidant function from oxidative damage [14] , and Se deficiency or excess causes a lot of selenoprotein resultant metabolic disorders in pig kidney [15] . cache = ./cache/cord-005379-5x4deimg.txt txt = ./txt/cord-005379-5x4deimg.txt === reduce.pl bib === id = cord-007580-qwh8ei60 author = Knopf, Harry L.S. title = Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date = 2014-09-26 pages = extension = .txt mime = text/plain words = 5104 sentences = 320 flesch = 53 summary = We had three major goals: to determine the rate of viral recovery from cases of nonepidemic acute or subacute follicular conjunc tivitis; to compare the accuracy of clinical diagnoses with that achieved by culture or serologic studies, or both; and to explore the possible role of serum antibody in the forma tion and maintenance of corneal subepithelial infiltrates. 4 VIRAL KERATOCONJUNCTIVITIS 663 antibody titers to vaccinia, herpes, coxsackievirus A-9, A-16, and A-21, and four strains of acute hemorrhagic conjunctivitis virus were similarly assayed by serum neutraliza tion tests in human diploid fibroblast tissue culture. Table 2* shows the difference between the number of positive isolates ob tained by culturing before or after the eighth * All of the data for the epidemic keratoconjunc tivitis group were published elsewhere, except for the corneal quantitative material in clinical studies.' day of illness. cache = ./cache/cord-007580-qwh8ei60.txt txt = ./txt/cord-007580-qwh8ei60.txt === reduce.pl bib === id = cord-003673-u7711eb4 author = Xiong, Xiao-Li title = Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile date = 2019-05-22 pages = extension = .txt mime = text/plain words = 6866 sentences = 470 flesch = 61 summary = Real-time PCR and Western blotting was employed to detect the mRNA and protein levels of BSEP in LO2 cell, rat primary hepatocytes and liver tissue. More importantly, our previous work revealed that emodin could alleviate intrahepatic cholestasis by promoting the expression of liver farnesoid X receptor (FXR), small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP), which are related to the synthesis, detoxification, and transportation process of Bas (Ding et al., 2016) . Therefore, this research used the LO2 cell line and ANIT-induced rat model to find how emodin interfered with the BSEP signaling pathway to alleviate intrahepatic cholestasis. As shown in Figure 8D , compared with the untreated cells, the emodin group showed significantly elevated mRNA levels of FXR and BSEP. For the LO2 cell experiment, the mRNA and protein expressions of FXR and BSEP were significantly elevated in the emodin group compared with control group. cache = ./cache/cord-003673-u7711eb4.txt txt = ./txt/cord-003673-u7711eb4.txt === reduce.pl bib === id = cord-013263-xw611i8k author = Dederichs, Melina title = Students’ perspectives on interventions to reduce stress in medical school: A qualitative study date = 2020-10-15 pages = extension = .txt mime = text/plain words = 5660 sentences = 351 flesch = 51 summary = title: Students' perspectives on interventions to reduce stress in medical school: A qualitative study 2. How do medical students perceive interventions that have been described in the literature (pass/fail grading, a peer-to-peer mentoring program, Balint groups, and self-management courses)? Possible solutions students brought up were for instance a mandatory lecture about stress related to medical school, coping strategies and support contacts. Participants proposed shortening clinical trainings, or to move them towards the end of the medical curriculum to avoid that students have to pass other exams right before the second state examination. In our eight focus groups, students suggested specific solutions to their perceived obstacles in medical school. Importantly, while setting-based interventions are sometimes considered expensive or difficult to implement [7] , most ideas in the focus groups (e.g. attendance rules, a new course selection procedure, teaching guidelines) seem easily feasible and resource-friendly and will not only improve wellbeing, but also academic performance. cache = ./cache/cord-013263-xw611i8k.txt txt = ./txt/cord-013263-xw611i8k.txt === reduce.pl bib === id = cord-004342-9uok77wb author = Lin, Chun-Yu title = Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date = 2020-02-14 pages = extension = .txt mime = text/plain words = 3003 sentences = 160 flesch = 36 summary = title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience This retrospective study aimed to clarify the shortand mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. In this single-centre study, a comparative cohort of patients who underwent surgical treatment for active LSNIE is presented, which includes 38 elderly patients aged >65 years. Due to the increase in average life expectancy and the higher incidence of cardiovascular disease with advancing age, more elderly patients nowadays present for cardiac surgery 22 . Therefore, we suggest that a guideline-directed surgical strategy according to the presence of complications, which include embolism events, large vegetation, heart failure, or uncontrolled infection, would be beneficial to improve the mid-term outcomes of elderly patients with LSNIE. cache = ./cache/cord-004342-9uok77wb.txt txt = ./txt/cord-004342-9uok77wb.txt === reduce.pl bib === id = cord-001809-azb7nie3 author = Qvarnstrom, Yvonne title = Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis date = 2013-07-24 pages = extension = .txt mime = text/plain words = 4509 sentences = 259 flesch = 57 summary = DNA sequence analysis, secondary structure prediction, and phylogenetic analysis of the 18S rRNA gene confirmed that this new strain belonged to Group 1, but that it was distinct from the other sequence types within that group. Amoebae belonging to Group 2 cause the majority of reported human infections (both AK and Acanthamoeba GAE) and also constitute the majority of the strains isolated from the environment. As a complement to the morphologic classification, molecular analyses using nuclear small subunit ribosomal RNA (18S rRNA) gene sequences have divided Acanthamoeba into 17 sequence types (designated T1-T17, also called ribotypes or genotypes) (Corsaro and Venditti 2010; Gast 2001; Gast et al. Molecular and structural analysis of the 18S rRNA gene concluded that it is genetically most similar to the other Group 1 species within the Acanthamoeba genus, confirming the description of CDC:V621 as a new Acanthamoeba Group I strain. cache = ./cache/cord-001809-azb7nie3.txt txt = ./txt/cord-001809-azb7nie3.txt === reduce.pl bib === id = cord-010390-lc22hp3o author = Nenna, Raffaella title = Age Limit in Bronchiolitis Diagnosis: 6 or 12 Months? date = 2020-04-20 pages = extension = .txt mime = text/plain words = 2048 sentences = 128 flesch = 51 summary = Bronchiolitis is a common cause of lower respiratory tract infection in infants and the major responsible factor of hospitalization under the age of one year, with the highest incidence occurring between December to March. The bivariate logistic regression designed to investigate the possible confounding factors (sex, clinical severity score, days of hospitalization and exposure to passive smoking, RSV, hBoV, and IV fluid) showed that the 6-12 months group had an odds ratio of hBoV detected at the NPA of 12.84 (95% CI 3.60-45.80) and the need of IV fluid of 0.45 (95% CI 0.20-0.99). According to our findings of a higher occurrence within the epidemic season and of the slightly higher frequency of recurrent wheezing at 36 months' follow-up, infants > 6 months seems represent a different group of patients hospitalized for bronchiolitis, who are more predisposed to childhood asthma. • Bronchiolitis is a common cause of lower respiratory tract infection in infants and the major responsible factor of hospitalization under the age of one year. cache = ./cache/cord-010390-lc22hp3o.txt txt = ./txt/cord-010390-lc22hp3o.txt === reduce.pl bib === id = cord-009962-k3opc553 author = Stjernquist‐Desatnik, Anna title = Pharyngotonsillitis date = 2008-12-17 pages = extension = .txt mime = text/plain words = 5501 sentences = 317 flesch = 32 summary = Acute rheumatic fever, the most serious nonsuppurative complication of beta-hemolytic group A streptococcal pharyngotonsillitis, is the leading cause of acquired heart disease among children in developing countries (5) . However, beta-hemolytic group A streptococci are amongst the most virulent human pathogens, and patients with pharyngotonsillitis caused by infection with this bacterium can be seriously affected with high fever, dysphagia and severe pain. The decline of acute rheumatic fever in the developed world may indeed be the result of routine antibiotic use for beta-hemolytic group A streptococcal pharyngotonsillitis, supporting the present principles of treatment. Penicillin V was detected in tonsillar surface fluid in a majority of patients on the first day of treatment of acute beta-hemolytic group A streptococcus pharyngotonsillitis, but despite a high concentration in serum, was rarely present on the 10th day or in healthy, treated subjects (81) . cache = ./cache/cord-009962-k3opc553.txt txt = ./txt/cord-009962-k3opc553.txt === reduce.pl bib === id = cord-006987-1hf8vyhz author = Abass, Ahmed O title = Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults date = 2017-10-05 pages = extension = .txt mime = text/plain words = 6779 sentences = 320 flesch = 46 summary = title: Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection. Thus, the current study was designed to investigate the effects of propolis supplementation on controlling the oxidative stress induced by paraquat injection to turkeys. In addition, growth performance of turkey birds was obtained under propolis supplementation in order to test whether it has the ability to reverse the negative effects of oxidative stress induced by paraquat. The current study also demonstrates that dietary propolis supplementation significantly increased plasma T 3 concentration in the PR+PQ group compared to PQ group which, consequently, alleviated the negative effect of paraquat injection on the growth performance of turkey poults. cache = ./cache/cord-006987-1hf8vyhz.txt txt = ./txt/cord-006987-1hf8vyhz.txt === reduce.pl bib === id = cord-006984-x1r99rlm author = Yokhana, J. S. title = Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry date = 2015-11-14 pages = extension = .txt mime = text/plain words = 7434 sentences = 400 flesch = 61 summary = At wk 10, relative weights of liver and gizzard of Group IF were heavier (P < 0.05) than other treatments; activities of pepsin, GP, trypsin and chymotrypsin of IF pullets were significantly greater than other treatments as was mRNA expression for pepsinogens A (25.9 vs. The first experiment was designed to determine whether the addition of a commercial IF product (Arbocel RC, JRS Co. Inc., Rosenberg, Germany) in the diets of young layer-strain pullets between the ages of 8 and 18 wk influenced supply organ growth and proteolytic enzyme activities in the proventriculus, pancreas, and small intestine. Feeding the IF diet to the older pullets (13 to 18 wk of age) for 5 wk (Group C-IF) had no significant effect (compared to controls) on activities of pepsin or the three pancreatic enzymes measured (Table 4 ). cache = ./cache/cord-006984-x1r99rlm.txt txt = ./txt/cord-006984-x1r99rlm.txt === reduce.pl bib === id = cord-010501-kd95xvsg author = Zenetos, Argyro title = Analysis of Benthic Communities in the Cyclades Plateau (Aegean Sea) Using Ecological and Paleoecological Data Sets date = 2008-06-28 pages = extension = .txt mime = text/plain words = 2856 sentences = 188 flesch = 54 summary = Standard multivariate analysis techniques were applied to both ecological (living benthic fauna) and paleoecological data sets in order to distinguish distribution patterns. The species richness, abundance, and diversity per station is given in Table 2 : the number of species ranged from 21 (station A23) to 100 (station A32), and the number of specimens from 152-m-2 (station A 17) to 432.m-2 (station A26 The dendrograms can be truncated at any level, but the areal presentation derived with MDS based on the total living fauna (Fig. 4 a) indicated that the more justified separation in terms of ecological sense was at the 4 groups level (25% similarity) (two dimensional stress = 0.141). The groups are based on the dendrogram of Fig. 2 Table 5 shows the results of the SPEARMAN rank correlation coefficient between the biotic parameters (number of macrofaunal species, number of specimens, and species diversity) and depth and sediment type. cache = ./cache/cord-010501-kd95xvsg.txt txt = ./txt/cord-010501-kd95xvsg.txt === reduce.pl bib === id = cord-012537-49v45di6 author = El-Ghandour, Mamdouh title = Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial date = 2020-08-28 pages = extension = .txt mime = text/plain words = 2825 sentences = 152 flesch = 46 summary = title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial OBJECTIVES: The current study aimed to investigate the efficacy of oral sildenafil and intravenous milrinone infusion and compare the effects of these drugs in combination versus as monotherapy in neonates with PPHN. In newborn care units lacking this gold standard therapy for PPHN, treatment comprises pulmonary vasodilators such as oral sildenafil or continuous intravenous infusion of milrinone. In the current randomized controlled trial, sildenafil combined with milrinone was more effective at normalizing pulmonary artery pressure and improving survival rates than treatment with either of the two drugs as monotherapy. Results from the current study showed that the combination of oral sildenafil and intravenous milrinone resulted in improved clinical outcomes, reflected by reduced mortality and a significant decrease in PASP. cache = ./cache/cord-012537-49v45di6.txt txt = ./txt/cord-012537-49v45di6.txt === reduce.pl bib === === reduce.pl bib === id = cord-010530-w8ir0e07 author = MOURA, HERCULES title = Acanthamoeba healyi N. Sp. and the Isoenzyme and Immunoblot Profiles of Acanthamoeba spp., Groups 1 and 3 date = 2007-05-01 pages = extension = .txt mime = text/plain words = 4382 sentences = 269 flesch = 62 summary = ABSTRACT Two strains of Acanthamoeba isolated from human brain tissue and a strain of Acanthamoeba isolated from a fish were compared with 10 species of Acanthamoeba belonging to groups 1, 2 and 3 based on their isoenzyme profiles and antigenic characteristics. The isoenzymes and antigens were electrophoretically separated on polyacrylamide gradient gels, and the patterns obtained were compared after appropriate staining for particular enzymes and reactivities with homologous and heterologous rabbit anti‐Acanthamoeba antisera. This paper presents the methods used to isolate Acanthamoeba from the CNS of humans and identify them to the species level based on morphologic characteristics and isoenzyme and antigenic profiles. A small piece of the biopsied brain tissue was frozen and sent to the Centers for Disease Control, where Acanthamoeba (CDC: 1283:V013) was isolated on non-nutrient agar plates seeded with Escherichia coli and MRC human lung cell culture [ 131. cache = ./cache/cord-010530-w8ir0e07.txt txt = ./txt/cord-010530-w8ir0e07.txt === reduce.pl bib === id = cord-011147-55whf8md author = Sun, Hengchang title = Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection date = 2020-01-07 pages = extension = .txt mime = text/plain words = 7864 sentences = 424 flesch = 56 summary = title: Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection Potential pathogenetic bacteria with lower abundance and higher abundances of candidate probiotics and bacteria associated with digestion in 1 × 10(11) CFU/g B.s-CotC-CsPmy spores administrated fishes could be detected compared with control group. In the present study, the specific IgM antibody levels in serum, bile, intestinal mucus, and skin mucus of grass carp orally administrated with different dosages of spores (B.s-CotC-CsPmy) were significantly increased with dosedependent from the 2nd week after the beginning of the immunization till to 6 weeks (Fig. 2) . Immune response induced by oral delivery of Bacillus subtilis spores expressing enolase of Clonorchis sinensis in grass carps (Ctenopharyngodon idellus) cache = ./cache/cord-011147-55whf8md.txt txt = ./txt/cord-011147-55whf8md.txt === reduce.pl bib === id = cord-014868-kg96uvpi author = Vita, S. title = Evaluation of Total Proteins and Serum Protein Fractions in Cats Naturally Infected by Leishmania infantum–A Preliminary Study date = 2006 pages = extension = .txt mime = text/plain words = 1264 sentences = 62 flesch = 52 summary = In canine leishmaniosis, laboratory parameters such as serum total proteins (TPs), albuminto-globulin (A/G) ratio, and single serum protein fractions have been proposed for their particular diagnostic significance and for monitoring the progress of the disease (Ceci and Petazzi, 1983; Bizzetti, 1998; Ciaramella and De Luna, 1999) . During the progress of feline leishmaniosis, some authors have observed increased serum TPs associated with hyper-γ-globulinemia and hypoalbuminemia with inversion of the A/G ratio and changes in the α-globulin fractions (Laurelle-Magalon and Toga, 1996 Hervas et al., 1999; Ozon et al., 1998; Pennisi, 2002; Poli et al., 2002) . To the best of our knowledge, the evaluation of serum protein changes has only been reported once for a group of FIV infected cats positive to PCR assay for Leishmania infantum (Pennisi et al., 2000) . The objective of this study was to evaluate serum TPs and some protein fractions in cats positive to Leishmania. cache = ./cache/cord-014868-kg96uvpi.txt txt = ./txt/cord-014868-kg96uvpi.txt === reduce.pl bib === id = cord-005777-6rvfsx4p author = nan title = PS 0420-0716 date = 2007-08-25 pages = extension = .txt mime = text/plain words = 59217 sentences = 3634 flesch = 53 summary = We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. cache = ./cache/cord-005777-6rvfsx4p.txt txt = ./txt/cord-005777-6rvfsx4p.txt === reduce.pl bib === id = cord-007367-e31zhty6 author = Tassier, Troy title = Network position and health care worker infections date = 2015-09-07 pages = extension = .txt mime = text/plain words = 11003 sentences = 567 flesch = 55 summary = We estimate, using an agent-based model, the effect of network position of different hospital worker groups on the spread of infectious diseases in a hospital. Following the theoretical discussion, we use our newly collected data on healthcare worker and patient contacts to model the spread of an infectious disease in a hospital setting. The model allows us to identify the healthcare worker groups that would be expected to play the largest role in the spread of infectious diseases, in terms of network position, in this hospital setting. Because of these difficulties we use a simulation approach to help us measure the average and marginal effects of individuals belonging to different worker groups in our hospital contact data. We discuss the data and use agent-based models to identify the healthcare workers whose position in the hospital contact network has the potential to create large numbers of infections in the hospital. cache = ./cache/cord-007367-e31zhty6.txt txt = ./txt/cord-007367-e31zhty6.txt === reduce.pl bib === id = cord-009969-ln91qfg4 author = Bertolesi, Gabriel E. title = Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl date = 2019-03-10 pages = extension = .txt mime = text/plain words = 9270 sentences = 487 flesch = 52 summary = We suggest an explanation for the differences in the mechanisms that evolved to regulate background adaptation by inferring ancestral relationships, and assessing associations with plastic colour change, the ability of α-MSH, MCH and MCHL peptides to be synthesized and secreted and to work as neuroendocrine hormones, as well as their effects on skin pigmentation. Interestingly, several species in this group lack the dual-hormonal mechanism, in that MCH/MCHL plasma levels but not α-MSH vary with background adaptation, including flounders (Verasper moseri and Platichthys flesus) (Gilham & Baker, 1984; Kang & Kim, 2013; Mizusawa et al., 2011) and tilapias from the genus Oreochromis (Nile and Mozambique) (Gröneveld, Balm, Martens et al., 1995a; Gröneveld, Balm, & Wendelaar Bonga, 1995b; van der Salm, Metz, Wendelaar Bonga, & Flik, 2005) . We used both the structure and presence of pomc, pmch and pmchl as a "genetic basis," alongside MCH/MCHL "hormonal status," to explain differences in the physiological mechanisms for background adaptation over evolution. cache = ./cache/cord-009969-ln91qfg4.txt txt = ./txt/cord-009969-ln91qfg4.txt === reduce.pl bib === === reduce.pl bib === id = cord-012518-ncrdwtdg author = nan title = Abstractband DOG 2020 date = 2020-08-24 pages = extension = .txt mime = text/plain words = 32627 sentences = 2475 flesch = 59 summary = The improvement in tear film quality (measured by TBUT) was shown after application of trehalose/hyaluronate tear substitute for one month in both, glaucoma and control group patients with mild to moderate dry eye symptoms. Methods: For 351 eyes (275 patients) who underwent DMEK for Fuchs endothelial corneal dystrophy (FECD), donor ECD decrease as compared to preoperative donor ECD was evaluated up to four years after surgery. The present study included fundus images of 111 individuals with a mean refractive error of -9.3 ± 3.8 diopters (range:-20.8, +1.75) and an axial length of 26.8 ± 1.9 mm (range: 22.55, 30.88) Results: The disc-fovea distance increased significantly with longer axial length, with a relatively flat slope in the non-highly myopic eyes (Disc-Fovea-Distance = 24.3 × Axial Length (mm)+514) and a steeper slope in the highly myopic group (Disc-Fovea-Distance = 58.7 × Axial Length (mm)-460). cache = ./cache/cord-012518-ncrdwtdg.txt txt = ./txt/cord-012518-ncrdwtdg.txt === reduce.pl bib === id = cord-013444-5aei9kaz author = Ruzauskas, Modestas title = The Influence of Essential Oils on Gut Microbial Profiles in Pigs date = 2020-09-24 pages = extension = .txt mime = text/plain words = 9199 sentences = 443 flesch = 45 summary = In this study, the microbial changes in pigs as experimental animals were assessed as influenced by consumption of oregano extract combination with peppermint and thyme essential oils. This study used pigs as an animal model for the assessment of the impact of consumption of Origanum vulgare plant extract combined with Mentha piperita and Thymus vulgaris essential oils on microbial profile in intestines. The results demonstrated that the combination of essential oils was non cytotoxic, and had a positive effect on the microbial composition in the large intestine of pigs due to significant increase in the number of probiotic bacteria. The aim of this study was to evaluate the cytotoxicity of Origanum vulgare plant extract, Mentha piperita, and Thymus vulgaris EOs and to evaluate microbial changes in the guts of pigs as experimental model by supplementing their diet with a combination of the aforementioned plant extract and two essential oils (EEOs) given in the form of bilayer coating tablets. cache = ./cache/cord-013444-5aei9kaz.txt txt = ./txt/cord-013444-5aei9kaz.txt === reduce.pl bib === id = cord-003532-lcgeingz author = nan title = 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date = 2019-03-19 pages = extension = .txt mime = text/plain words = 79997 sentences = 5146 flesch = 52 summary = It's proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. cache = ./cache/cord-003532-lcgeingz.txt txt = ./txt/cord-003532-lcgeingz.txt === reduce.pl bib === === reduce.pl bib === id = cord-014670-e31g8lns author = nan title = Poster Sessions 313-503 date = 2004-10-05 pages = extension = .txt mime = text/plain words = 28575 sentences = 1706 flesch = 55 summary = Over a 12-month period patients who needed reintubation after successful trial of weaning and planned extubation, in a polyvalent intensive care unit (ICU) were identified.Data including clinical features (age, sex, SAPS II on admission, Glasgow Coma Score (GCS) on day of extubation, type of patient, length of intubation and mechanical ventilation (MV) before extubation, length of ICU stay (LOS), ICU and hospital mortality) were collected.Moreover we considered two parameters that asses airway patency and protection like predictors of EF:cough strength and suctioning frequency after extubation.Cough strength on command was measured with a semiobjective scale of 0 to 5 (0= weak cough, 5= strong cough). (3/23)(13.2%), pulmonary embolism(1/23)(4.3%)and severe sepsis(1/23)(4.3%).Seven of patients who received reintubation a cause of defective airway manage needed at least one suctioning every two hours; moreover the same patients and other three with alteration in neurological function had weak cough (grade 0 to 2).The LOS of EF patients was 23±24.3 days, their ICU and hospital mortality were 39.1% and 47.8%, respectively, both higher when compared with not reintubated patients.Results of logistic regression showed that SAPS II is the only independent risk-factor of reintubation (odds ratio 1.056, sig. cache = ./cache/cord-014670-e31g8lns.txt txt = ./txt/cord-014670-e31g8lns.txt === reduce.pl bib === === reduce.pl bib === id = cord-014538-6a2pviol author = Kamilia, Chtara title = Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date = 2017-01-10 pages = extension = .txt mime = text/plain words = 61068 sentences = 3463 flesch = 49 summary = Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). cache = ./cache/cord-014538-6a2pviol.txt txt = ./txt/cord-014538-6a2pviol.txt === reduce.pl bib === id = cord-005816-i54q5gsu author = nan title = 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date = 2009-08-06 pages = extension = .txt mime = text/plain words = 83124 sentences = 5617 flesch = 53 summary = Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. cache = ./cache/cord-005816-i54q5gsu.txt txt = ./txt/cord-005816-i54q5gsu.txt === reduce.pl bib === id = cord-005881-oswgjaxz author = nan title = Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date = 2010 pages = extension = .txt mime = text/plain words = 71955 sentences = 4561 flesch = 52 summary = Prospective case series with historical control group.(Level III) Results: Preliminary data indicate: *a shorter time on ventilator than anticipated (based on comparisson to historical data) * a shorter time on ICU * less pneumoniae * no intra-operative complications * good healing results of the rib fractures * no implant failures * acceptable pain scores * good overal satisfaction * acceptable cosmetic results Conclusion: Internal fixation of rib fractures (flair chest or multiple sequential fractures with pulmonary function compromise) results in a earlier recuperation of pulmonary function with shortened ICU stay. (Regional Association Sanitary Emergencies) Material and Methods: The ARES, whose members are about 600, all over the nation, is configured as an extraordinary health resource, activated by the National Civil Defence operations centre, in according with the Regional centre of Marche, in disater situations Results: The main objectives of ARES are training and organization of medical staff and structures and its growth crosses several missions including: AE Earthquake in Molise, 2002 Introduction: Cephalomedullary nails rely on a large lag screw that provides fixation into the femoral head. cache = ./cache/cord-005881-oswgjaxz.txt txt = ./txt/cord-005881-oswgjaxz.txt === reduce.pl bib === id = cord-015082-l629n8is author = nan title = Poster Sessions 323-461 date = 2002-08-29 pages = extension = .txt mime = text/plain words = 26569 sentences = 1648 flesch = 52 summary = 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. cache = ./cache/cord-015082-l629n8is.txt txt = ./txt/cord-015082-l629n8is.txt === reduce.pl bib === id = cord-011062-ukz4hnmy author = nan title = Poster date = 2020-03-11 pages = extension = .txt mime = text/plain words = 88313 sentences = 5669 flesch = 55 summary = Ming-Yueh Chou 1,3 , Ying-Hsin Hsu 1 , Yu-Chun Wang 1 , Chih-Kuang Liang 1,3 , Li-Ning Peng 2,4 , Liang-Kung Chen 2,4 , Yu-Te Lin 1 ((1) Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; (3) Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; (4) Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan) Background: Older people with frailty are at risk of adverse outcomes, such as falls, functional decline and mortality, and multi-domain intervention program may prevent those. Conclusion: Our study showed that a multicomponent exercise program is effective for posthospitalization patients because after 24-week intervention there were significant reductions in frailty and improving results in muscle strength and physical performance. Methods: Cross-sectional analysis of 757 communitydwelling older adults who completed multi-domain geriatric screen assessing for social vulnerability, mood, cognition, functional performance, nutrition, physical frailty (FRAIL) and sarcopenia (SARC-F). cache = ./cache/cord-011062-ukz4hnmy.txt txt = ./txt/cord-011062-ukz4hnmy.txt === reduce.pl bib === id = cord-014996-p6q0f37c author = nan title = Posters_Monday_12 October 2009 date = 2009-08-06 pages = extension = .txt mime = text/plain words = 85190 sentences = 5288 flesch = 54 summary = Data recorded on admission were the patient demographics with, acute physiology and chronic health evaluation II score (APACHE II), and type of admission; during intensive care stay, sepsis-related organ failure assessment score (SOFA) and clinical concomitant factors and conditions. For each severe septic patient the following data was registered: time delay, APACHE II and SOFA scores at ICU admission, diagnosis, the rate of compliance with the resucitation and management bundles, microbiological data, evolution of levels of serum lactate, empiric antibiotic therapy, length of stay and mortality in ICU. Sepsis and septic shock remain the most important causes of acute kidney injury (AKI) in critically ill patients and account for more than 50% of cases of acute renal failure (ARF) in intensive care units (ICU). There were no significant differences between the demographic data (sex, age) or the data on admission to intensive care (APACHE II score, ratio of medical to surgical patients) and duration of mechanical ventilation between the two groups. cache = ./cache/cord-014996-p6q0f37c.txt txt = ./txt/cord-014996-p6q0f37c.txt === reduce.pl bib === id = cord-014516-r59usk02 author = nan title = Research Communications of the 24th ECVIM‐CA Congress date = 2015-01-10 pages = extension = .txt mime = text/plain words = 55041 sentences = 2919 flesch = 51 summary = Serum prolactin concentration measured in 22/23 dogs at time zero, 6 weeks and 6 months was 3.35 ng/ml (range, 1.4-6.36), 3.57 ng/ml (range, 1.87-7.39) and 3.92 ng/ml (range, 2.01-12.92) and did not differ significantly in either time period when compared with time zero (P = 0.99 and P = 0.52).Altogether, results of this study failed to demonstrate a significant role of thyroid supplementation on the majority of evaluated behavioural symptoms as well as neurohormonal status of hypothyroid dogs during 6 months of therapy. The aims of the present study were (1) to describe a clinical series of recent autochtonous cases and (2) to retrospectively assess Angiostrongylus vasorum qPCR in bronchoalveolar lavage fluid (BALF) samples, collected over the last 7 years from a larger series of dogs, healthy or with other respiratory conditions, in order to investigate the past prevalence of the disease in Belgium. cache = ./cache/cord-014516-r59usk02.txt txt = ./txt/cord-014516-r59usk02.txt === reduce.pl bib === id = cord-018813-9hoksa86 author = Waito, Marianne title = A Mathematical Model of Cytokine Dynamics During a Cytokine Storm date = 2016-02-17 pages = extension = .txt mime = text/plain words = 2893 sentences = 156 flesch = 52 summary = The dynamics of cytokines during normal immune responses and even more so during storms are highly complex and little is known about specific interactions [5, 27] . Combining these approaches can result in major advancements in both the understanding of cancer and immune system dynamics including cytokine interactions, with the potential to identify strategies to control toxic cytokine storms [26] . Following administration of a highly attenuated virus to mice with leukocytes lacking the type I IFN receptor, a deadly cytokine storm developed leading to death in only 24 h. Data was collected and provided by Dr. Byram Bridle, Dr. Scott Walsh and Alexandra Rasiuk who study the role of type I IFN signalling in the regulation of cytokine responses at the OVC. The model provides an accurate fit to the cytokine time series data for both IFNAR-knockout and wild-type mice (not shown). cache = ./cache/cord-018813-9hoksa86.txt txt = ./txt/cord-018813-9hoksa86.txt === reduce.pl bib === id = cord-015126-cyhcbk1j author = nan title = PS 0036-0344 date = 2007-08-25 pages = extension = .txt mime = text/plain words = 59175 sentences = 3672 flesch = 54 summary = We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. cache = ./cache/cord-015126-cyhcbk1j.txt txt = ./txt/cord-015126-cyhcbk1j.txt === reduce.pl bib === id = cord-017067-19eawrjt author = Ogbondah, Chris Wolumati title = Terrorists and Social Media Messages: A Critical Analysis of Boko Haram’s Messages and Messaging Techniques date = 2017-10-24 pages = extension = .txt mime = text/plain words = 11733 sentences = 617 flesch = 59 summary = An examination of Boko Haram's attempts to win the battle for the hearts and minds of Nigerians through a deliberate use of video propaganda as well as a critical analysis of the statements by its leader, Shekau, will provide governmental and institutional policymakers in Nigeria a deeper understanding of the nature and operations of Boko Haram. 1) This chapter is also significant because by analyzing the speeches made by Boko Haram's leader in the social media and in particular YouTube videos and major acts of terrorism carried out by the group, Nigerian and West African leaders and leaders elsewhere in the world might further understand how the minds of the leaders of terrorist organizations work. In one thirty-six-minute YouTube video that the authors accessed at https://www.youtube.com/watch?v=MgdKblgzggQ, Shekau boasts that the avalanche of weapons that Boko Haram captured from fleeing Nigerian soldiers including those seized during its attack on Baga in Borno State would be enough for the Jihadists to successfully prosecute the entire war. cache = ./cache/cord-017067-19eawrjt.txt txt = ./txt/cord-017067-19eawrjt.txt === reduce.pl bib === id = cord-016559-tqd7m2i1 author = Zheng, Yi title = Application in Medicine Systems date = 2014-10-28 pages = extension = .txt mime = text/plain words = 19346 sentences = 778 flesch = 48 summary = Danshen has the function of effectively dilating the coronary artery, increasing coronary blood flow, reducing heart rate, inhibiting platelet aggregation and thrombopoiesis induced by platelet activation factors, promoting the recovery of injured cardiac muscle, increasing cardiac contractility, and protecting cardiac muscle cells; thus it can be widely applied in treating the diseases of the circulation system. [7] reported the application of 0.5/ 250 ml of puerarin and glucose injection combined with 16 ml of CDI in the treatment of 44 patients with coronary heart disease and angina pectoris, and the results showed that in the treatment group there were 31 patients with a marked effect, 10 patients with an effect, 3 patients without effect, and the total effective rate was 93.2 %. Patients with cerebral hemorrhage were treated with CDI, and the rates of recovery and significant improvement in the treatment group were significantly better than those in the control group, and no side effects were observed. cache = ./cache/cord-016559-tqd7m2i1.txt txt = ./txt/cord-016559-tqd7m2i1.txt === reduce.pl bib === id = cord-014533-6qfecv5h author = Velasquez, T. title = ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date = 2016-09-29 pages = extension = .txt mime = text/plain words = 88380 sentences = 5139 flesch = 52 summary = P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. Methods: This descriptive observational study was conducted on consecutive 100 pediatric surgical patients who admitted to PSICUs at Cairo University Hospitals starting from 1/6-1/12/2015.After approval by research ethics committee,informed consents were obtained from parents and pediatric cases aged from 1 month-18 years and stayed for > 48 h were enrolled.MPV and PLC were obtained and recorded at baseline(preoperative values),on the day of ICU admission(day 0),1 st ,2 nd ,3 rd ,5 th and 7 th days.To measure daily MPV changes; (ΔMPV) was constructed and computed where ΔMPV = ([MPVday(X) − MPVday (0)]/MPVday(0) × 100 %. Results: The results obtained after analyzing the two homogeneous groups according to age, gender, type of admission and severity influencing the physiotherapy care in ICU quality indicators, in the Sagrada Esperança clinic, highlights the decrease of the average number of days with mechanical ventilation but it is not observed a significant relation between physical therapy and this indicator (p = 0:06). cache = ./cache/cord-014533-6qfecv5h.txt txt = ./txt/cord-014533-6qfecv5h.txt === reduce.pl bib === id = cord-005497-w81ysjf9 author = nan title = 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date = 2020-03-24 pages = extension = .txt mime = text/plain words = 103623 sentences = 6176 flesch = 53 summary = The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). cache = ./cache/cord-005497-w81ysjf9.txt txt = ./txt/cord-005497-w81ysjf9.txt === reduce.pl bib === id = cord-005105-twsy61oq author = nan title = SIU 2015 Abstracts date = 2015-09-21 pages = extension = .txt mime = text/plain words = 124096 sentences = 7584 flesch = 54 summary = Th e present study is based on a retrospective analysis of a database of over 600 patients (age range 17-57 years) who met the consensus criteria for bacterial prostatitis, 75% of whom had dysuria, 35% perineal discomfort, 60% had obstructive luts, 37% infertility of unknown etiology, 10% erectile dysfunction and 25% recurrent infection of the partner. Further research is needed to determine to assess whether localization of small volume disease on 68Ga-PSMA PET/CT can improve diagnostic algorithms and outcomes in patients with recurrent PCa. Introduction and Objective: To assess long-term results of salvage pelvic lymph node dissection (PLND) in prostate cancer (PC) patients (pts) with biochemical recurrence aft er primary local treatment and confi rmed solitary lymph node (LN) metastases. cache = ./cache/cord-005105-twsy61oq.txt txt = ./txt/cord-005105-twsy61oq.txt === reduce.pl bib === id = cord-022879-j6cecioe author = Fager, Edward W. title = Determination and Analysis of Recurrent Groups date = 1957-10-01 pages = extension = .txt mime = text/plain words = 6287 sentences = 279 flesch = 57 summary = Transformation of the data or the use of rank correlation could overcome this difficulty, but any method which involves a measure of abundance may, in certain cases, not lead to the desired results : two species may always occur together and never separately and yet, unless there is a nearly constant relation between the relative numbers of individuals of the two species, a correlation coefficient will indicate no relationship even though they are a constant part of each other's biological environment. The following example shows that it is not a satisfactory criterion for grouping if the groups are to be composed of species which form a nearly constant part of each other's biological environment: Species 1 and 2 show no evidence of association when examined by Cole's method and yet they nearly always occur together-over 80% of the occurrences of each are in company with the other -and should be considered together in any grouping based on this set of samples. cache = ./cache/cord-022879-j6cecioe.txt txt = ./txt/cord-022879-j6cecioe.txt === reduce.pl bib === id = cord-005727-li8pwigg author = nan title = ESICM 2010 MONDAY SESSIONS 11 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 102770 sentences = 6408 flesch = 53 summary = Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. cache = ./cache/cord-005727-li8pwigg.txt txt = ./txt/cord-005727-li8pwigg.txt === reduce.pl bib === id = cord-015024-2xzc0uc5 author = nan title = ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date = 2010-08-31 pages = extension = .txt mime = text/plain words = 84393 sentences = 5234 flesch = 52 summary = We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). cache = ./cache/cord-015024-2xzc0uc5.txt txt = ./txt/cord-015024-2xzc0uc5.txt === reduce.pl bib === id = cord-006854-o2e5na78 author = nan title = Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date = 2018-04-20 pages = extension = .txt mime = text/plain words = 166047 sentences = 10353 flesch = 47 summary = Totally Laparoscopic ALPPS Combined with the Microwave Ablation for a Patient with a Huge HCC Hua Zhang; Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting hepatic tumors that were previously considered unresectable due to the insufficient future liver remnant (FLR) which may result in postoperative liver failure (PLF). Not only does this case show that a large epiphrenic diverticulm can be successfully resected via the trans-abdominal laparoscopic approach, this case makes the argument that patients undergoing any minimally-invasive epiphrenic diverticulectomy and myotomy, with or without fundoplication, may be successfully managed with early post-operative contrast studies and dietary advancement, thus decreasing their length of hospitalization and overall cost of treatment. Introduction: There are reports of increased operative duration, blood loss and postoperative morbidity, caused by difficulties in obtaining good visualization and in controlling bleeding when laparoscopic resection is performed in obese patients with colon cancer. cache = ./cache/cord-006854-o2e5na78.txt txt = ./txt/cord-006854-o2e5na78.txt === reduce.pl bib === id = cord-015372-76xvzvdg author = nan title = National scientific medical meeting 1996 abstracts date = 1996 pages = extension = .txt mime = text/plain words = 36596 sentences = 2204 flesch = 53 summary = One, two and five-year survival rates were examined; age at diagnosis and lesion type were extremely significant factors in relation to patient outcome. Patients' age, sex, risk group, CDC stage, CD4 count, indication for therapy, complication rate and response to treatment are described. Fifty-eight patients (34 male, 24 female) ranging in age from 15 to 65 years (Mean + SD = 28.4 + 10.8) were included in the study. Among these 48 patients (mean age 68.0+12.7), after controlling for age and for the duration and continuity of subsequent antipsychotic treatment, increasing duration of initially untreated psychosis was associated with greater severity of negative symptoms (p<0.005) and with lower scores on the MMSE (p<0.05) but not with executive dysfunction on the EXIT (p=0.3). Conclusion Although not a population based study, care of IDDM in Ireland is almost totally hospital clinic based Cigarette smoking is identified as the major problem to be addressed Patients with diabetes meltitus (DM) are at a higher risk of developing vascular complications, including coronary artery disease (CAD). cache = ./cache/cord-015372-76xvzvdg.txt txt = ./txt/cord-015372-76xvzvdg.txt === reduce.pl bib === id = cord-014527-nvzfpntu author = nan title = Research Communications of the 25th ECVIM‐CA Congress date = 2015-11-09 pages = extension = .txt mime = text/plain words = 89238 sentences = 4996 flesch = 52 summary = A negative outcome was associated with higher fecal S100A12 concentrations in CE dogs, but the response to different forms of treatment and fecal S100A12 has not been reported, and this information will be important to further evaluate the utility of fecal S100A12 as a biomarker for gastrointestinal disease. Statistical analysis was performed using non-parametric 2-or multiple-group comparisons, the likelihood ratio to evaluate the association between groups of dogs and response to treatment, and a receiver operating characteristic curve to calculate sensitivity and specificity at the optimum cut-off concentration. The objectives of this study were to describe pulmonary transit time and myocardial perfusion normalized to heart rate (nPTT and nMP, respectively), evaluated by means of contrast echocardiography, in dogs with stable stage C ACVIM myxomatous mitral valve disease (MMVD), and to assess short-term effects of pimobendan on these parameters. cache = ./cache/cord-014527-nvzfpntu.txt txt = ./txt/cord-014527-nvzfpntu.txt === reduce.pl bib === id = cord-014464-m5n250r2 author = Sole-Violan, J title = Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date = 2013-03-19 pages = extension = .txt mime = text/plain words = 98961 sentences = 5553 flesch = 54 summary = Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. cache = ./cache/cord-014464-m5n250r2.txt txt = ./txt/cord-014464-m5n250r2.txt === reduce.pl bib === id = cord-010980-sizuef1v author = nan title = ECTES Abstracts 2020 date = 2020-05-11 pages = extension = .txt mime = text/plain words = 132644 sentences = 8727 flesch = 53 summary = We hypothesized that presentation to a PTC would yield increased mortality when subspecialty intervention was required and that this would be most pronounced at night when in-house attending coverage is absent at all state PTCs. Materials and methods: A review of the Pennsylvania Trauma Outcome Study (PTOS) database was performed to capture patients aged 12-18 who underwent any non-orthopedic trauma surgery. Traumatic subaxial cervical fractures: functional prognostic factors and survival analysis Introduction: The main goal of this study is to identify the risk factors for poor functional outcomes and to analyze the overall survival (OS) and complications rate in patients with traumatic cervical spinal cord injury (SCI) and subaxial cervical fracture (SACF) treated with open surgical fixation. After applying a multiple imputation on all the study variables, a logistic regression generalized estimating equation after adjustment for age, sex, mechanism of trauma, and the injury severity score as covariates and hospitals as a cluster assessed an association between quartile of patient volume in intensive care unit and hospital mortality. cache = ./cache/cord-010980-sizuef1v.txt txt = ./txt/cord-010980-sizuef1v.txt === reduce.pl bib === id = cord-022643-2j559muh author = Chance, Gail D. title = SYSTEMATIC IMPLICATIONS OF SEED COAT MORPHOLOGY IN NAMA (HYDROPHYLLACEAE) date = 1984-07-01 pages = extension = .txt mime = text/plain words = 4604 sentences = 282 flesch = 57 summary = Nevertheless, similarities among species in seed coat organization, particularly, outer testa anatomy and wall thickening‐pitting patterns allow the recognition of six groups among examined taxa; furthermore, seed coat features often suggest both intra‐group and inter‐group relationships. Hitchcock's (1933) observation that seeds of different species exhibit variously patterned surfaces offers a promising point of departure for studies aimed at elucidating relationships in Nama. Seed Group 3 (Fig.11-19 )-Thesixincluded species are characterized by a reticulate seed coat in which pits-perforations (Fig. 11 , 15) are found in radial walls of the reticulum cells. Seed Group 4 (Fig. 20-35 )-Each ofthe nine species in this group produces a chambered coat ranging from weakly to deeply reticulate; and all possess localized thickenings in the radial walls of reticulum cells (Fig. 22, 23, 27-29, 32, 35) . In contrast to other species ofits group, unbranched thickenings often traverse the floor of reticulum cells (Fig. 35) and are reminiscent of those found in Seed Group 5. cache = ./cache/cord-022643-2j559muh.txt txt = ./txt/cord-022643-2j559muh.txt === reduce.pl bib === === reduce.pl bib === id = cord-022973-soaz8b74 author = Trivellini, Guido title = Nestedness of habitat specialists within habitat generalists in a butterfly assemblage date = 2016-09-25 pages = extension = .txt mime = text/plain words = 5103 sentences = 251 flesch = 46 summary = Butterflies (Lepidoptera) are a well-studied insect group both taxonomically and ecologically (e.g. Gilbert, 1984; Kocher & Williams, 2000; Ghazoul, 2002; Stefanescu et al., 2004 Stefanescu et al., , 2011 , particularly because they interact with plants both as larval herbivores and adult pollinators (Borges et al., 2003; Hardy et al., 2007) and have different habitat requirements even at each life stage (New et al., 1995; Samways & Lu, 2007; Dennis, 2010) . E-mail: giuseppe.bogliani@unipv.it These largely specialised butterfly-habitat associations are influenced by many physical and biological factors (Leps & Spitzer, 1990; Spitzer et al., 1993) , including temperature, humidity, light levels, rainfall patterns, local microclimate conditions, grassland type and host-plant species richness and distribution (Hill et al., 2001; Meyer & Sisk, 2001; Collinge et al., 2003; Men endez et al., 2007) . To do this, we first defined the requirements, i.e., which habitat types positively or negatively correlate with species abundances, and then used a network-based approach (Bl€ uthgen et al., 2006) to analyse the degree of habitat use overlap within groups of species with similar habitat requirements. cache = ./cache/cord-022973-soaz8b74.txt txt = ./txt/cord-022973-soaz8b74.txt === reduce.pl bib === id = cord-000083-3p81yr4n author = nan title = Poster Exhibition date = 2009-01-31 pages = extension = .txt mime = text/plain words = 112815 sentences = 7542 flesch = 56 summary = R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. cache = ./cache/cord-000083-3p81yr4n.txt txt = ./txt/cord-000083-3p81yr4n.txt === reduce.pl bib === id = cord-026983-36n7bm3j author = Gillani, Syeda Shaista title = Synthesis, characterization and applications of poly-aliphatic amine dendrimers and dendrons date = 2020-06-17 pages = extension = .txt mime = text/plain words = 6437 sentences = 393 flesch = 51 summary = Figure 1 shows the well-defined structure of a dendrimer composed of various components: a) Multiple reactive sites originate from the central core which further grows into branches layer-by-layer in a symmetric fashion to form dendrimer generations. In PPI and PAMAM dendrimers, the number of pincers is half the amount of terminal surface groups as in these dendrimers, the chain disconnects into two chains in each focal point. Literature reveal the synthesis of a number of aliphatic polyamide amine dendrimers shown in PAMAM dendrons based silica-coated magnetic nanoparticles have been synthesized (Fig. 9 ). The structures and tunable surface functionalities of dendrimers allow for the encapsulation/complexation/conjugation of multiple entities, i.e. the drug molecules, and genetic materials, targeting agents and dyes, either in the core or on the surface, rendering them ideal carriers for various drugs. There are many examples where dendritic species including PAMAM dendrimers have been incorporated into scaffolds for the regeneration of a variety of tissues and cell types [127] . cache = ./cache/cord-026983-36n7bm3j.txt txt = ./txt/cord-026983-36n7bm3j.txt === reduce.pl bib === id = cord-006849-vgjz74ts author = nan title = 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date = 2019-09-13 pages = extension = .txt mime = text/plain words = 222162 sentences = 14023 flesch = 48 summary = Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient's evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. cache = ./cache/cord-006849-vgjz74ts.txt txt = ./txt/cord-006849-vgjz74ts.txt === reduce.pl bib === === reduce.pl bib === id = cord-021419-nypnib0h author = Olsufyeva, Evgenia N. title = Main trends in the design of semi-synthetic antibiotics of a new generation date = 2020-03-17 pages = extension = .txt mime = text/plain words = 16144 sentences = 923 flesch = 45 summary = In this review, the following classes of compounds are considered as scaffolds for the synthesis of new antibiotics: polycyclic glycopeptides of the vancomycin ± teicoplanin group, classical macrolides, macrolides of the amphotericin B ± oligomycin group, anthracyclines, aureolic acid derivatives, heliomycin, synthetic benzoxaboroles and some other antibiotics. 42 Antibacterial activity of derivatives 52 ± 55 modified at the C(11)7OH group of the aglycone was evaluated compared to the starting antibiotics vancomycin (1) and azithromycin (30) on a panel of Gram-positive and Gramnegative bacterial strains (8 and 3 strains, respectively). In order to improve antifungal properties, cytotoxic and therapeutic characteristics and to study the mechanisms of action, series of new semi-synthetic derivatives based on AmB (63a) and bioengineered analogues S44HP (64a), BSG005 (65a), BSG022 (66a), BSG019 (67), BSG003 (68a) and BSG018 (69) were synthesized (in collaboration with the company BIOSERGEN, Norway) (Scheme 17). cache = ./cache/cord-021419-nypnib0h.txt txt = ./txt/cord-021419-nypnib0h.txt === reduce.pl bib === id = cord-024461-xo75855r author = Zhang, Yuanzhe title = FCP Filter: A Dynamic Clustering-Prediction Framework for Customer Behavior date = 2020-04-17 pages = extension = .txt mime = text/plain words = 3883 sentences = 227 flesch = 55 summary = In the meanwhile, Fragmentation and Coagulation Process (FCP), a stochastic partition model, has recently been proposed for identifying dynamic customer groups and modeling their purchase behavior. In our model, FCP clusters customers into groups by their temporal interests to filter random noise of individual transaction data. We conduct experiments on both synthetic and real-world datasets, demonstrating that our model is able to discover the latent group of individual customers and provides accurate predictions for dynamic purchase behavior. In order to track the customers' temporal shifting across groups, a novel Bayesian non-parametric customer segmentation model FC-CSM [7] based on a random partition process, Fragmentation and Coagulation Process (FCP) [1] , was proposed. We conducted experiments on synthetic and real-world datasets to illustrate that our model can (1) identify dynamic customer groups based on purchase behavior, (2) achieve more accurate prediction results by filtering individual random noise. cache = ./cache/cord-024461-xo75855r.txt txt = ./txt/cord-024461-xo75855r.txt === reduce.pl bib === id = cord-023186-gqltd6u0 author = nan title = Poster Sessions date = 2019-06-27 pages = extension = .txt mime = text/plain words = 14365 sentences = 814 flesch = 55 summary = Methods: This is a one-year retrospective study that was conducted in our pediatric intensive care unit (PICU) comparing the intervention failure rate of three different Noninvasive respiratory support modalities (bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP) and HFNC) for infants and young children between the ages of 1 month and 2 years admitted with the diagnosis of bronchiolitis. The aim of the study was to determine the association between Methods: Ninety children aged between > 28 days to < 5 years hospitalized with diagnosis of severe CAP in the Pediatric Department of West Nusa Tenggara Province General Hospital from January to October 2018 were enrolled. Arterial blood gases, respiratory rate, peak inspiratory pressure (PIP) and mean airway pressure (MAP) of rat lung during respiratory support, wetto-dry lung weight ratio, lung homogenate and/or bronchoalveolar lavage fluid tumor necrosis factor-α, macrophage inflammatory protein-2, interleukin-6 and total protein levels were measured and compared among groups after study completion. cache = ./cache/cord-023186-gqltd6u0.txt txt = ./txt/cord-023186-gqltd6u0.txt === reduce.pl bib === id = cord-032657-1egdwe26 author = Gouda, Walaa title = COVID-19 disease: CT Pneumonia Analysis prototype by using artificial intelligence, predicting the disease severity date = 2020-09-25 pages = extension = .txt mime = text/plain words = 4128 sentences = 205 flesch = 50 summary = Groups B and C showed significantly increased number of involved lung segments and lobes, frequencies of consolidation, crazy-paving pattern, and air bronchogram. CT severity score was estimated for each one of the five lung lobes by calculating the dissemination of the chest manifestations (opacity), namely the ground-glass opacities (GGO), consolidation, crazy-paving pattern, septal thickening, and pulmonary fibrosis giving score (0-4) for 0, 25, 50, and ≥ 75% involvement, respectively, with the sum representing the total severity scores for the whole lung (0-20). In our study, qualitative chest findings such as consolidation, air bronchogram, septal thickening, lung fibrosis, and pleural effusion showed a significant difference between group A and other groups (B and C) with P value < 0.001, but it could not differentiate between groups B and C. cache = ./cache/cord-032657-1egdwe26.txt txt = ./txt/cord-032657-1egdwe26.txt === reduce.pl bib === id = cord-026493-z2hthkgy author = Newsom, Megan title = New and Emerging Systemic Treatments for Atopic Dermatitis date = 2020-06-09 pages = extension = .txt mime = text/plain words = 4136 sentences = 198 flesch = 47 summary = In two phase III clinical trials, BREEZE-AD1 and BREEZE-AD2, by 16 weeks, a higher proportion of subjects in the treatment groups (1 mg, 2 mg, and 4 mg) achieved an IGA of 0 or 1, a ≥ 2-point improvement, and EASI-75 compared with the group receiving placebo (Table 1 ) [40] . In a phase IIb trial evaluating abrocitinib in moderate-to-severe AD by week 12, a higher proportion of subjects receiving 200 mg of drug and 100 mg of drug (43.8% and 29.6%) had an IGA of 0 or 1 plus a ≥ 2-point improvement from baseline compared with those receiving placebo (5.8%; p < 0.001 and p < 0.001, respectively) [41] . Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 Randomized Clinical Trial Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b Randomized Clinical Trial cache = ./cache/cord-026493-z2hthkgy.txt txt = ./txt/cord-026493-z2hthkgy.txt === reduce.pl bib === id = cord-023225-5quigar4 author = nan title = Posters date = 2012-08-21 pages = extension = .txt mime = text/plain words = 70251 sentences = 3367 flesch = 43 summary = To further explore the structure-function relationship, a viable synthesis strategy for pseudodesmin A analogues was developed, based on side-chain attachment of the first amino acid to the solid support, followed by stepwise Fmoc solid-phase synthesis of the linear peptide precursor and on-resin head-to-tail cyclization. The cases when the amino acid sequence of a fragment coincided with part of the primary structure of a natural oligopeptide were recorded in the Total protein chemical synthesis requires a case by case design and optimization which is governed by factors such as the solubility of the individual peptide segments, their primary sequence and in particular the presence of "difficult" amino acid residues at ligation junctions such as proline or the location of cysteines. In this study we present synthesis of two series of peptide libraries, which were designed by substitution of Leu in the P5, P6 position of our control peptide (Ac-LLLLRVKR-AMBA) with each of nineteen amino acid residues in order to verifying its influence on activity and selectivity of the resulting analogues. cache = ./cache/cord-023225-5quigar4.txt txt = ./txt/cord-023225-5quigar4.txt === reduce.pl bib === id = cord-015368-a0qz4tb9 author = nan title = 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date = 2007 pages = extension = .txt mime = text/plain words = 86620 sentences = 6042 flesch = 51 summary = Surgical treatment and evaluation, complications, short and long term patency of our patients were compared to interventional techniques and international literature. The aim of the study was to investigate: i) relevant and combined determinants of the development, management and outcome of a representative patient cohort (n ¼ 9.991) with acute appendicitis enrolled in a prospective unicenter study through a time period of 27 years (middle Europe), and ii) the frequency and impact of specific categories (e.g., characteristics of the medical history, clinical and intraoperative findings, complications), correlation and relative risk factors of the disease and its prognosis. From 01=1997 until 12=2006 198 TEM procedures were performed in 194 patients, 104 males, 90 females, mean age was 68.9 years (38-91), the median hospital stay was 8 days . No conversion to open technique had to be performed, no postoperative surgical complications were observed, one patient died 4 weeks postoperative due to liver failure following esophageal varices bleeding. cache = ./cache/cord-015368-a0qz4tb9.txt txt = ./txt/cord-015368-a0qz4tb9.txt === reduce.pl bib === id = cord-032410-g546hez9 author = Hu, Yuan title = Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depression date = 2020-08-27 pages = extension = .txt mime = text/plain words = 4639 sentences = 234 flesch = 48 summary = In the present study, we aimed to explore whether KXS had both antidepressive effects and cardioprotective functions in a rat model of myocardial ischemia (MI) with depression. RESULTS: After 7 weeks of experiment, depression-like behaviors were observed in all the groups except for control and KXS groups, and KXS treatment dramatically increased open-field test scores and sucrose consumption (P < 0.01 vs. However, after 28 days, the sucrose consumption and open-field test scores were significantly reduced in the depression and model groups (data not shown), and such results were consistent with previous study . In the present study, we found that KXS had antidepressive effect and cardioprotective function by a rat model of MI with depression. After KXS treatment, open-field test scores, and sucrose consumption, which are indicators for evaluating depression-like behaviors, were significantly increased compared with the model group. cache = ./cache/cord-032410-g546hez9.txt txt = ./txt/cord-032410-g546hez9.txt === reduce.pl bib === id = cord-030277-x9zvx3fp author = Ohta, Yoshinori title = Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial date = 2020-08-10 pages = extension = .txt mime = text/plain words = 4064 sentences = 215 flesch = 52 summary = title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitonin, and thus on inflammation, in patients with sepsis enrolled in a randomized clinical trial. METHODS: The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. We analyzed data derived from a randomized clinical trial and found that the administration of dexmedetomidine to patients with sepsis on ventilators improved CRP and PCT levels during the first 14 days in the ICU. In the present study, the use of dexmedetomidine for sedation reduced both CRP and PCT levels in patients with sepsis. Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial cache = ./cache/cord-030277-x9zvx3fp.txt txt = ./txt/cord-030277-x9zvx3fp.txt === reduce.pl bib === id = cord-023134-y665agnh author = nan title = Oral Research Communications of the 22(nd) ECVIM‐CA Congress date = 2012-11-20 pages = extension = .txt mime = text/plain words = 29595 sentences = 1548 flesch = 50 summary = Doppler echocardiographic indices of diastolic function of the right ventricle are good prognostic markers during left ventricular (LV) failure secondary to ischemic and dilated cardiomyopathy.The aims of the present study were: to assess LV and RV diastolic function by conventional Doppler and pulsed-wave tissue Doppler imaging (PW-TDI) in dogs with mitral valve disease (MVD), with or without pulmonary hypertension (PH); to test if echocardiographic parameters of LV and RV diastolic dysfunction correlate to the Doppler-estimated pulmonary artery systolic pressure (PASP).114 dogs were prospectively evaluated, including 86 dogs with MVD. The aims of the present study were to assess whether diabetic cats have pathological evidence of islet inflammation or pancreatitis and to define islet lesions in comparison to a well-matched control population.Formalin-fixed, paraffin-embedded pancreatic samples were collected from post-mortem examination performed on diabetic and control cats died due to any disease at the Clinic for Small Animal Internal Medicine, University of Zurich (Switzerland) between 1997 and 2009. cache = ./cache/cord-023134-y665agnh.txt txt = ./txt/cord-023134-y665agnh.txt === reduce.pl bib === === reduce.pl bib === id = cord-023017-k6edtg58 author = nan title = AASLD Abstracts (pp. 282A–382A) date = 2006-02-10 pages = extension = .txt mime = text/plain words = 65796 sentences = 3553 flesch = 51 summary = 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. cache = ./cache/cord-023017-k6edtg58.txt txt = ./txt/cord-023017-k6edtg58.txt === reduce.pl bib === id = cord-022653-qa1uph35 author = nan title = Poster Discussion Session PDS date = 2017-08-30 pages = extension = .txt mime = text/plain words = 58292 sentences = 3300 flesch = 53 summary = 0206 | G protein coupled receptor kinase 2 (GRK2) regulates endothelial permeability induced by Bradykinin 0208 | Pharmacokinetics (PK) and pharmacodynamics (PD) of c1 esterase inhibitor of chronic urticaria challenges most commonly identified were the following: time of onset of disease; frequency/duration of and provoking factors for wheals; diurnal variation; occurrence in relation to weekends, holidays, and foreign travel; shape, size, and distribution of wheals; associated angioedema; associated subjective symptoms of lesions; family and personal history regarding urticaria, atopy; previous or current allergies, infections, internal diseases, or other possible causes; psychosomatic and psychiatric diseases; surgical implantations and events during surgery; gastric/ intestinal problems; induction by physical agents or exercise; use of drugs; food allergies; relationship to the menstrual cycle; smoking habits; type of work, hobbies; stress; quality of life and emotional impact; previous therapy and response to therapy, and previous diagnostic procedures/results. cache = ./cache/cord-022653-qa1uph35.txt txt = ./txt/cord-022653-qa1uph35.txt === reduce.pl bib === id = cord-023311-7wqdlha4 author = nan title = Oral Session date = 2010-11-24 pages = extension = .txt mime = text/plain words = 17248 sentences = 956 flesch = 51 summary = Methods We determined the usefulness of preoperative lung function by spirometry in predicting regression of pulmonary hypertension after surgical correction of mitral stenosis among 20 patients who underwent mitral valve surgery at Philippine Heart Center from July to December 2009. Elderly patients exhibited a signifi cantly higher mortality rate that was independently associated with the following: age; residence status; confusion, urea, respiratory frequency and blood pressure (CURB) score; comorbid conditions; and failure of initial therapy. Methods A total of 40 patients (Male: 50%; Female: 50%) admitted and diagnosed with HAP at our Center were followed up to investigate the rate of adherence of physicians on the diagnosis and treatment of HAP based on Level I and II ATS/IDSA 2008 recommendations and to determine its association with outcome (mortality, mechanical ventilation, ICU stay, hospital stay). cache = ./cache/cord-023311-7wqdlha4.txt txt = ./txt/cord-023311-7wqdlha4.txt === reduce.pl bib === id = cord-024698-jrnw1i07 author = Hogan, Kevin title = Decidio: A Pilot Implementation and User Study of a Novel Decision-Support System date = 2020-04-25 pages = extension = .txt mime = text/plain words = 4017 sentences = 266 flesch = 58 summary = 3 we present the use case for the user study of Decidio and demonstrate how our tool was incorporated into an existing group decision-making process. Students logged into Decidio via their personal laptops and navigated to the group project ranking dashboard. Learn their process, methods, and strategies employed for decision-making when ranking projects as a group 3. An activity log file created for every user that captured their actions as a workflow diagram was used to understand how student groups used Decidio in their decision making process. Finally, it is difficult to generalize results about user behavior in the tool when each team consists of a different mix of personalities and individual ranking preferences. In this paper, we present Decidio, a software tool that supports collaborative decision making. The activity logs showed us the various workflows used by student groups for decision-making. cache = ./cache/cord-024698-jrnw1i07.txt txt = ./txt/cord-024698-jrnw1i07.txt === reduce.pl bib === id = cord-034714-6e37yylk author = Alleg, Manel title = Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML date = 2020-11-06 pages = extension = .txt mime = text/plain words = 3746 sentences = 170 flesch = 37 summary = title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximabthan natalizumab-associated PML OBJECTIVES: To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. Inclusion criteria were (1) a "definite" PML diagnosis according to the American Academy of Neurology criteria [19] including clinical and imaging-compatible features and detection of JCV DNA in the cerebrospinal fluid or in brain tissue by polymerase chain reaction (PCR) or immunohistochemistry; (2) HIV-infected patients or patients treated with immunomodulatory or immunosuppressive drugs such as natalizumab or rituximab, possibly in association with other drugs and whatever the initial illness; and (3) consent was provided for in the hospital's charter. This study aims to describe the MRI characteristics of PML associated with rituximab and natalizumab and in HIV infection while comparing imaging findings with the level of immunosuppression. cache = ./cache/cord-034714-6e37yylk.txt txt = ./txt/cord-034714-6e37yylk.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-193497-qqrhvlm5 author = Shoghri, Ahmad El title = Identifying highly influential travellers for spreading disease on a public transport system date = 2020-04-03 pages = extension = .txt mime = text/plain words = 5889 sentences = 299 flesch = 46 summary = For instance previous work has explored the impact of recurring patterns inherent in human mobility on disease spread, but has not considered other dimensions such as the distance travelled or the number of encounters. In this paper we study three aspects of mobility behaviour, i.e. the degree of exploration, the distance travelled and the number of encounters of passengers using the Sydney bus network in the context of infectious disease spread. An increase in the infection probability on the other hand, amplifies the spreading power of all mobility groups, especially for passengers who regularly visit the same places and travel short distances, until reaching a saturation point at a probability of 0.5. Interestingly, the averages of received infections per individual is nearly the same across all the groups with a value just divide individuals into explorers and returners, but to distinguish them further along other dimensions such as the distance travelled and the connectivity as their spreading abilities differ. cache = ./cache/cord-193497-qqrhvlm5.txt txt = ./txt/cord-193497-qqrhvlm5.txt === reduce.pl bib === id = cord-032979-jle66lmn author = ROMMEREIM, D. N. title = Reproduction, Growth, and Development of Rats during Chronic Exposure to Multiple Field Strengths of 60-Hz Electric Fields date = 1990-04-17 pages = extension = .txt mime = text/plain words = 6167 sentences = 325 flesch = 56 summary = journal: Fundam Appl Toxicol Female rats were mated, and sperm-positive animals randomly distributed among four groups: sham-exposed or exposed to 10, 65, or 130 kV/m, 60-Hz vertical electric fields. Female rats were mated, and sperm-positive animals randomly distributed among four groups: sham-exposed or exposed to 10, 65, or 130 kV/m, 60-Hz vertical electric fields. Accordingly, in the study reported here we tested for a treatment-related response, utilizing multiple exposure groups, including 65 -cV/m (effective field strength) as used in our arevious experiments; 130 kV/m which was :wice as strong as that used in the previous ,vork and had been shown to be tolerated by •ats (Rommereim et al, 1989) ; the lowest evel of exposure (10 kV/m) was chosen to deineate the response curve at lower field strengths or possibly to determine a no-obierved-effect level; and the fourth group was sham-exposed as a control. Mean number of live fetuses per litter was less in rats exposed to the 130 kV/m field, but it was not statistically different from the control group {p = 0.33). cache = ./cache/cord-032979-jle66lmn.txt txt = ./txt/cord-032979-jle66lmn.txt === reduce.pl bib === id = cord-000977-ka4261wc author = nan title = ECR 2013 Book of Abstracts - B - Scientific Sessions date = 2013-03-07 pages = extension = .txt mime = text/plain words = 132895 sentences = 8080 flesch = 50 summary = Methods and Materials: Mean attenuation, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) at abdominal aorta, right renal artery (RRA) and left renal artery (LRA) were measured in 24 kidney donors who had undergone CTA with tube current modulation, 120 kVp, filtered back projection reconstruction algorithm (Group A) and were compared with 24 BMI-matched kidney donors who had undergone CTA with automated kVp selection and SAFIRE (Group B Purpose: Cerebral small vessel disease (SVD) is a common cause of cognitive impairment. Overall average score of SSF reconstructed segments was significantly higher compared with STD reconstruction ( Purpose: To evaluate the feasibility and imaging quality of double prospectively ECG-triggered high-pitch spiral acquisition mode for coronary computed tomography angiography (CTCA) in patients with atrial fibrillation (AF). cache = ./cache/cord-000977-ka4261wc.txt txt = ./txt/cord-000977-ka4261wc.txt === reduce.pl bib === id = cord-234996-hah19vmk author = Kabiri, Aliakbar title = How different age groups responded to the COVID-19 pandemic in terms of mobility behaviors: a case study of the United States date = 2020-07-20 pages = extension = .txt mime = text/plain words = 3654 sentences = 155 flesch = 46 summary = In this paper, we attempt to fill the current gap in the literature by examining how different communities with different age groups performed social distancing by following orders such as the national emergency declaration on March 13, as well as how fast they started changing their behavior after the regulations were imposed. For this purpose, we calculated the behavior changes of people in different mobility metrics, such as percentage of people staying home during the study period (March, April, and May 2020), in different age groups in comparison to the days before the pandemic (January and February 2020), by utilizing anonymized and privacy-protected mobile device data. Several aspects of mobility patterns including percentage of people staying at home and social distancing index, have been investigated in this paper to illustrate how different age groups behave during the pandemic. cache = ./cache/cord-234996-hah19vmk.txt txt = ./txt/cord-234996-hah19vmk.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-014794-yppi30a0 author = nan title = 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date = 2003-07-31 pages = extension = .txt mime = text/plain words = 158059 sentences = 9041 flesch = 44 summary = These parts were in a high percentage associated with fibrosis and lymphocyte rich areas and showed a higher mitotic activity than usual PTCs. Discussion The differences in the occurrence of TCV and TCmorphology between the presented series and previously reported cases might result from until now not clearly defined tall cell morphology as well as from similarities to PTCs, such as the oxyphilic variant, which is extremely rare in our series, and maybe also from often described squamous changes within PTCs. Due to these data it is not clear which tumor parts have relevance for prognosis and which tumors should be treated more aggressively than others. The aims of this study were to characterize the group of patients with BSOT and evaluate the significance of various molecular markers expression versus serous papillary ovarian carcinomas (SPOC) Material and methods We analyzed a total of 102 cases including: 64 cystadenoma, 10 borderline and 28 cystadenocarcinoma. cache = ./cache/cord-014794-yppi30a0.txt txt = ./txt/cord-014794-yppi30a0.txt === reduce.pl bib === id = cord-261163-n9tp9nx7 author = Ko, Jae-Hoon title = Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity date = 2017-10-31 pages = extension = .txt mime = text/plain words = 3140 sentences = 144 flesch = 44 summary = Abstract We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). Based on these findings, we evaluated serologic response of 42 MERS-CoV-infected patients according to the disease severity to investigate potential role of serodiagnostic parameters as prognostic markers. Although different seroconversion rates depending on disease severity can be inferred from previous serologic investigation (Min et al., 2016) , the number of evaluated MERS patients was limited to 14 and neutralization testing was not performed. Serologic response was delayed in Group 3 patients, and negative seroconversion by the third week of illness was associated with fatal outcome among patients with MERS pneumonia (HR 27.83, 95% CI 2.76-280.21, P = 0.005). cache = ./cache/cord-261163-n9tp9nx7.txt txt = ./txt/cord-261163-n9tp9nx7.txt === reduce.pl bib === id = cord-009567-osstpum6 author = nan title = Abstracts Oral date = 2008-04-23 pages = extension = .txt mime = text/plain words = 131214 sentences = 7728 flesch = 53 summary = Introduction: Previously, it has been demonstrated that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during cardiac rejection, suggesting infiltration of regulatory T cells in the transplanted organ during an allogeneic response. Efficacy and safety parameters assessed at follow-up included: acute rejection; patient and graft survival; renal function, vital signs, basic lab results and immunosuppressive regimen for the patients 10 years after completion of the original study. We analyzed, for the first time, the expression of TLR4 in PBMC from kidney recipients with contrasted situations: operational tolerance and chronic immune-mediated rejection (Banff 2005), compared to patients with normal histology and stable graft function, non transplant patients with renal failure and healthy volunteers. cache = ./cache/cord-009567-osstpum6.txt txt = ./txt/cord-009567-osstpum6.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-264607-5vnaifi6 author = Chen, Wenyu title = A study on clinical effect of Arbidol combined with adjuvant therapy on COVID‐19 date = 2020-06-08 pages = extension = .txt mime = text/plain words = 2520 sentences = 137 flesch = 53 summary = OBJECTIVES: This study aims to explore the clinical effect of Arbidol (ARB) combined with adjuvant therapy on patients with coronavirus disease 2019 (COVID‐19). Various indexes in the two groups before and after treatment were observed and recorded, including fever, cough, hypodynamia, nasal obstruction, nasal discharge, diarrhea, C‐reactive protein (CRP), procalcitonin (PCT), blood routine indexes, blood biochemical indexes, time to achieve negative virus nucleic acid and so on. All clinical data of patients, including gender, hypertension, diabetes, CT, temperature, oxygen saturation, hemoglobin (HB) concentration, C-reactive protein (CRP) and so on, were listed in Table 1 Test group: ARB was additionally added on the basis of symptomatic treatment. Patient's clinical symptoms, such as fever, dry cough, nasal obstruction, nasal discharge, sore throat, hypodynamia, diarrhea, and some laboratory indexes including blood routine indexes, CRP, procalcitonin (PCT), blood biochemical indexes as well as the virus nucleic acid testing were observed and recorded during the treatment. cache = ./cache/cord-264607-5vnaifi6.txt txt = ./txt/cord-264607-5vnaifi6.txt === reduce.pl bib === === reduce.pl bib === id = cord-262716-hea84shy author = Pourali, Fatemeh title = Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis date = 2020-08-11 pages = extension = .txt mime = text/plain words = 3858 sentences = 208 flesch = 57 summary = The reported results were controversial, so the objective of the present study is to assess the relationship between different blood groups and the onset and mortality of COVID-19 infection using meta-analysis method. Note that there are limited primary evidence regarding the association between blood groups and COVID19 infection, upcoming relevant studies will be added to the results of the present meta-analysis. Of the evidence included in this meta-analysis, five studies had reported the frequency of blood group AB among COVID-19 infected people varied between 3.08% and 13.68%. Combining the results of this two evidence, applying random effect model (I-square=0%, Q=0.41, P=0.522), the odd ratio for death among COVID-19 infected people having blood group A was estimated as 1.12 (95% CI: 0.87, 1.45). Meta-analysis of studies showed no significant association between mortality and different blood groups in COVID-19 patients. cache = ./cache/cord-262716-hea84shy.txt txt = ./txt/cord-262716-hea84shy.txt === reduce.pl bib === id = cord-239632-dyvhzvmm author = McGuigan, Michael title = Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning date = 2020-08-03 pages = extension = .txt mime = text/plain words = 5028 sentences = 232 flesch = 55 summary = title: Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning Figure 6 : Infections as a function of time for two age groups (0 − 49) and 50+ where there is a nondiagonal contact matrix in the SIRD model describing the interaction between the two age groups during the pandemic. Figure 7 : Deaths as a function of time for two age groups (0 − 49) and 50+ where there is a nondiagonal contact matrix in the SIRD model describing the interaction between the two age groups during the pandemic. We put these features together in models with mixing between different age groups, mixing with different countries and the effect of waning of nonspecific vaccines that were designed for different diseases but can lessen the severity of infection and mortality for a pathogen associated with a pandemic. cache = ./cache/cord-239632-dyvhzvmm.txt txt = ./txt/cord-239632-dyvhzvmm.txt === reduce.pl bib === id = cord-260272-645g3to1 author = Haddad, Kevin title = COVID-19 implications on STEMI care date = 2020-09-19 pages = extension = .txt mime = text/plain words = 2058 sentences = 113 flesch = 56 summary = In the context of a global lockdown, both new organizational barriers and patients' fear of acquiring COVID-19 have led to major concerns of undue delays in seeking appropriate emergent care, in particular for ST-elevation myocardial infarction (STEMI) patients. A total of 167 patients with STEMI were included in our analysis (72 from the Cité-de-la-Santé Killip class at time of hospital presentation was more advanced for patients with a STEMI during the lockdown period compared to the pre-COVID era, with significantly more cases categorized as a Killip class >1 (Group A 18.3% vs. J o u r n a l P r e -p r o o f Journal Pre-proof MACE rates after the index procedure for patients admitted during the lockdown period were significantly higher than those observed in 2019 during the same period or the one recorded between January and mid-March 2020 (22.6% vs. Indeed, our study highlights that, during the lockdown period, delays in seeking care were associated with more advanced heart failure on presentation and significantly higher rates of inhospital MACE. cache = ./cache/cord-260272-645g3to1.txt txt = ./txt/cord-260272-645g3to1.txt === reduce.pl bib === id = cord-261073-s0qpiovr author = Ehrengut, W. title = A two year serological surveillance of coronavirus infections in Hamburg date = 1980 pages = extension = .txt mime = text/plain words = 1356 sentences = 81 flesch = 52 summary = The occurrence of OC-43 coronavirus-like infections in the population of Hamburg was determined by a monthly serological survey (hemagglutination inhibition test [HI]) undertaken between October 1974 and October 1976. Serological surveillance carried out at regular intervals on a large number of sera taken from representative groups reveals the total infection rates (apparent and non-apparent) and the level and distribution of the seroimmunity in the population. The following report of seroepidemiological studies of coronavirus infections is based upon observations made in the course of a surveillance programme in Hamburg (carried out since October 1974) in various sections of the population in which all age groups were represented. Serological study of coronavirus antibodies in Hamburg Occurrence of antibody against coronavirus (OC43) in the healthy population and in patients with a disease of the respiratory tract Seroepidemiologic survey of coronavirus (Strain OC 43) related infections in a children's population cache = ./cache/cord-261073-s0qpiovr.txt txt = ./txt/cord-261073-s0qpiovr.txt === reduce.pl bib === id = cord-270727-2dd3b7di author = Rivera-Benitez, José Francisco title = Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus date = 2016-02-29 pages = extension = .txt mime = text/plain words = 6469 sentences = 342 flesch = 55 summary = A Student's t-test assuming unequal variance and a significance level of P 0.05 was used to compare rectal temperatures and the viral load of PorPV and swH1N1 in different samples (nasal and oral swabs, respiratory tissues and SLO) between the single-infected groups to the co-infected group. In the nasal swabs, samples that tested positive for PorPV were detected from 24 h post-infection up to 28 DPI (PorPV/Mock and PorPV/swH1N1 groups) (Fig. 3a) , and there were no differences (P > 0.05) in the mean of viral loads at any time analysed for these two groups. The pigs in the Mock/swH1N1 group presented the lowest respiratory signs and rectal temperatures, with no pigs showing a difference in respiration or temperature after experimental infection, a finding that is in accordance with studies that used low-virulence swine influenza virus strains (Busquets et al., 2010) . cache = ./cache/cord-270727-2dd3b7di.txt txt = ./txt/cord-270727-2dd3b7di.txt === reduce.pl bib === id = cord-266722-qfn2dc1q author = Wormser, Gary P. title = Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date = 1987-06-30 pages = extension = .txt mime = text/plain words = 5482 sentences = 272 flesch = 38 summary = Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these "nonpathogens." This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). The skin lesions are tender and consist of papules and clear vesicles with a surrounding zone of erythema.617 Pharyngitis with tonsillar exudate persisting for 4 or more days with a negative throat culture for group A streptococci, or occurring in association with diffuse lymphadenopathy, splenomegaly or with many atypical lymphocytes on blood smear suggests the possibility of infectious mononucleosis (IM) (Epstein-Barr virus). cache = ./cache/cord-266722-qfn2dc1q.txt txt = ./txt/cord-266722-qfn2dc1q.txt === reduce.pl bib === id = cord-270210-gfy2ytg5 author = Drent, Marjolein title = Benefit of Wearing an Activity Tracker in Sarcoidosis date = 2020-08-22 pages = extension = .txt mime = text/plain words = 4444 sentences = 243 flesch = 51 summary = The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). The aim of this study was to estimate (1) the potential effect of continuous activity monitoring using an electronic AT, compared with a historical control group in a cohort study and (2) the effect of additional personal coaching of sarcoidosis patients in a randomized trial. Wearing an AT in general, even without personal coaching by a physical therapist, improved exercise capacity and reduced fatigue in sarcoidosis patients. cache = ./cache/cord-270210-gfy2ytg5.txt txt = ./txt/cord-270210-gfy2ytg5.txt === reduce.pl bib === id = cord-274396-l611eisi author = Park, Su-Jin title = Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets date = 2020-05-22 pages = extension = .txt mime = text/plain words = 4355 sentences = 208 flesch = 46 summary = While the lopinavir-ritonavir-, hydroxychloroquine sulfate-, or emtricitabine-tenofovir-treated group exhibited lower overall clinical scores than the phosphate-buffered saline (PBS)-treated control group, the virus titers in nasal washes, stool specimens, and respiratory tissues were similar between all three antiviral-candidate-treated groups and the PBS-treated control group. Compared to the PBS-treated control group, azathioprine-immunosuppressed ferrets exhibited a longer period of clinical illness, higher virus titers in nasal turbinate, delayed virus clearance, and significantly lower serum neutralization (SN) antibody titers. In order to determine the antiviral efficacies of lopinavir-ritonavir, hydroxychloroquine (HCQ) sulfate, or emtricitabine-tenofovir for treatment of SARS-CoV-2 infection, SARS-CoV-2 antibody-free ferrets (10/group) were inoculated with 10 5.8 50% tissue culture infective doses (TCID 50 )/ml of an NMC-nCoV02 strain through the intranasal (i.n.) route ( Fig. 1 ). Therefore, although clinical symptoms were attenuated in ferret groups treated with antiviral candidates, we also evaluated virus titers in respiratory and gastrointestinal tracts using nasal washes and stool samples, respectively, from SARS-CoV-2-infected ferrets. cache = ./cache/cord-274396-l611eisi.txt txt = ./txt/cord-274396-l611eisi.txt === reduce.pl bib === id = cord-271106-srym2kh4 author = De Rosa, Nicoletta title = Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study date = 2019-04-11 pages = extension = .txt mime = text/plain words = 3179 sentences = 162 flesch = 44 summary = title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study In conclusion, the presence of a latent infection causes condylomatosis relapse; in order to reduce the relapse risk an induction of a protective immune response seems to be essential to allow rapid viral clearance from genital areas surrounding lesion and treatment zones. EP and EA dry root extracts seem to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis. Therapy with HPVADL18 is effective in reducing relapse incidence of lesions in patients treated for genital condylomatosis. In conclusion, HPVADL185 seems to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis. cache = ./cache/cord-271106-srym2kh4.txt txt = ./txt/cord-271106-srym2kh4.txt === reduce.pl bib === id = cord-261380-xms5su6w author = Rahmani, Hamid title = Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date = 2020-08-24 pages = extension = .txt mime = text/plain words = 2770 sentences = 170 flesch = 51 summary = Among an open-label, randomized clinical trial, adult patients (≥ 18 years old) with severe COVID-19 were randomly assigned (1:1) to the IFN group or the control group. According to the presence of this evidence, IFN β was considered as a promising option for the treatment of In this open-label, randomized clinical trial, efficacy and safety of IFN β-1b in the treatment of patients with severe CoVID-19 were assessed. This open-label, randomized clinical trial was designed to evaluate the efficacy and safety of IFN β-1b in the treatment of patients with CoVID19 Adult patients (≥ 18 years old) with positive PCR and clinical symptoms/signs of pneumonia (including dyspnea, cough and fever), peripheral oxygen saturation (SPO 2 ) ≤ 93 % in ambient air or arterial oxygen partial pressure to fractional inspired oxygen (PaO 2 /FiO 2 ) < 300 or SPO 2 /FiO 2 < 315 and lung involvement in chest imaging were included. cache = ./cache/cord-261380-xms5su6w.txt txt = ./txt/cord-261380-xms5su6w.txt === reduce.pl bib === id = cord-023364-ut56gczm author = nan title = EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130049 sentences = 7334 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023364-ut56gczm.txt txt = ./txt/cord-023364-ut56gczm.txt === reduce.pl bib === id = cord-270998-1adloi3o author = Cunha, Rafes D. S. title = Comparison of immunity against canine distemper, adenovirus and parvovirus after vaccination with two multivalent canine vaccines date = 2020-04-27 pages = extension = .txt mime = text/plain words = 2424 sentences = 125 flesch = 50 summary = There is a belief among veterinary practitioners and even educational institutions that the vaccines made in Brazil against canine distemper virus (CDV), canine parvovirus (CPV) and canine adenovirus (CAV) are ineffective or only partially effective. METHODS: The study was carried out at the Animal Protection Association and a total of 60 adult mongrel dogs were selected and divided into two groups. RESULTS: In group A, the Elevencell vaccine generated a protective antibody titre against CDV in 26 out of 28 subjects (92.85%), CPV in 24 out of 28 subjects (85.71%) and CAV in 26 out of 28 subjects (92.85%). Before immunization, both groups of animals presented results of ≤2 on the colorimetric scale, which means that all of them were eligible to take part in the vaccination protocol. Evaluation of the humoral immune response induced by vaccination for canine distemper and parvovirus: A pilot study cache = ./cache/cord-270998-1adloi3o.txt txt = ./txt/cord-270998-1adloi3o.txt === reduce.pl bib === id = cord-272497-ww9o1kjr author = Al-Anzi, Bader S. title = An Overview of the World Current and Future Assessment of Novel COVID-19 Trajectory, Impact, and Potential Preventive Strategies at Healthcare Settings date = 2020-09-25 pages = extension = .txt mime = text/plain words = 8892 sentences = 396 flesch = 58 summary = The current study aims to assess the trajectory of the recent pandemic due to the COVID-19 outbreak utilizing a new splitting methodology of the selected countries into two groups and developing regression-based and SIR-based statistical models and tools that depict the actual recorded data of COVID-19. Figure 1 was generated to show the recorded daily total infected cases of the world over a certain timeframe (22 January 2020 until present), which shows that the COVID-19 disease started to increase slowly until about 11 March and then accelerated at a faster speed afterwards. Figure 1 was generated to show the recorded daily total infected cases of the world over a certain timeframe (22 January 2020 until present), which shows that the COVID-19 disease started to increase slowly until about 11 March and then accelerated at a faster speed afterwards. cache = ./cache/cord-272497-ww9o1kjr.txt txt = ./txt/cord-272497-ww9o1kjr.txt === reduce.pl bib === id = cord-274121-3w6kc0c9 author = Ramiro, Sofia title = Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date = 2020-07-20 pages = extension = .txt mime = text/plain words = 5757 sentences = 267 flesch = 47 summary = Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. ► A strategy involving a course of high-dose glucocorticoids, followed by tocilizumab if needed, has shown to accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation compared with supportive care only in COVID-19-associated CSS. cache = ./cache/cord-274121-3w6kc0c9.txt txt = ./txt/cord-274121-3w6kc0c9.txt === reduce.pl bib === id = cord-273839-oasgagpc author = Bisno, Alan L. title = Diagnosis and Management of Group A Streptococcal Pharyngitis: A Practice Guideline date = 1997-09-17 pages = extension = .txt mime = text/plain words = 5771 sentences = 295 flesch = 41 summary = Except under special circumstances, neither repeated bacteri-Evidence ologic testing (culture or RADT) of patients who have success-We reviewed a large number of clinical trials of diagnostic fully completed a course of antimicrobial therapy nor routine and treatment strategies for group A streptococcal pharyngitis. ple, studies of treatment were evaluated for randomization, A small percentage of patients will have recurrences of acute blinding, use of streptococcal typing to differentiate treatment pharyngitis that are associated with throat cultures (or RADTs) failures from new infections, duration and timing of follow-up positive for group A streptococci within a short period following examinations, and statistical power [1, 2] . Such tests are appropriate for streptococci in the upper respiratory tract and for the confirmation of the clinical diagnosis of acute streptococcal pharyngitis use by microbiology laboratory personnel, but most physicians who perform throat cultures would find it difficult to justify [12] (category A, grade II). cache = ./cache/cord-273839-oasgagpc.txt txt = ./txt/cord-273839-oasgagpc.txt === reduce.pl bib === id = cord-019347-tj3ye1mx author = nan title = ABSTRACT BOOK date = 2010-02-19 pages = extension = .txt mime = text/plain words = 107926 sentences = 6940 flesch = 53 summary = Method:Case Report:A 15y/o w/f athlete presented with a two month history of recurrent hives and angioedema which she associated with ingestion of Halloween candy .One week before evaluation she had hives with Coconut as well.Her history was othewise unremarkable except for recurrent UTI'S, annual sinusitis, pneumonia in 1998 as well as migraines.She denied sexual activity.Her physical exam was normal.Results:An evaluation for autoimmune disease revealed normal ESR, ANA, DSDNA, mono and hepatitis serology as well as lyme titers however her CH50 was low17u/ml(normal 26-58U/ml)and evaluation of complement revealed c4 14mg/dl(normal 16-47mg//dl)and c2 <1.3mg/dl(normal 1.6-3.5mg/dl)with normal c3, c5-c9.Her father had nor-malc4 but c2 was 1.4mg/dl (normal 1.6-3.5mg/dl)Her sister had c2 of 1.5mg/dl and normal c4 and her mother had normal c2 and c4.Her workup included positive prick skin test to ragweed, ash and grass and she was started on Rhinocort and Clarinex seasonally.She has been followed for one year with resolution of hives and is asymptomatic.Her diagnosis had been confirmed by a pediatric rheumatologist.Conclusion;We present an atypical case of C2 complement deficiency in an currently asymptomatic individual. cache = ./cache/cord-019347-tj3ye1mx.txt txt = ./txt/cord-019347-tj3ye1mx.txt === reduce.pl bib === id = cord-274563-jimw6skv author = Fiumara, Agata title = COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date = 2020-08-22 pages = extension = .txt mime = text/plain words = 3524 sentences = 163 flesch = 50 summary = During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Based on the feeling that our patients were experiencing profound distress, we designed a structured interview [3, 4] with the aim to evaluate how, and to which extent, the COVID-19 pandemic was changing our patients' behavior and feelings about their chronic disease, the impact on therapies, and their future expectations. cache = ./cache/cord-274563-jimw6skv.txt txt = ./txt/cord-274563-jimw6skv.txt === reduce.pl bib === id = cord-022650-phsr10jp author = nan title = Abstracts TPS date = 2018-08-14 pages = extension = .txt mime = text/plain words = 119675 sentences = 7010 flesch = 55 summary = 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. cache = ./cache/cord-022650-phsr10jp.txt txt = ./txt/cord-022650-phsr10jp.txt === reduce.pl bib === id = cord-274497-tqceazdp author = N. Nuñez, Luis Fabian title = Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date = 2020-07-25 pages = extension = .txt mime = text/plain words = 4123 sentences = 192 flesch = 47 summary = In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch's postulates according to our previous description [21] . In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch's postulates according to our previous description [21] . Experimental infections with isolated ChPV (ABU-P1) have demonstrated that the virus causes enteric diseases, resulting mainly in chickens with diarrhea, cloacal pasting, impaired growth, runting and stunting [32] . Lesions were previously described in commercial chicken flocks affected with RSS and reported by our own group [21] ; the duodenal loop presented the same features, demonstrating Koch's postulates in relation to ChPV and experimentally infected chickens. cache = ./cache/cord-274497-tqceazdp.txt txt = ./txt/cord-274497-tqceazdp.txt === reduce.pl bib === === reduce.pl bib === id = cord-275499-25dp6u68 author = Tan, Zhen title = Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets date = 2019-12-30 pages = extension = .txt mime = text/plain words = 4432 sentences = 244 flesch = 47 summary = In this study, we successfully demonstrated that the microbial community structure of colonic mucosa and content differed significantly between healthy and PEDV-infected piglets. Likewise, previous research has shown that the proportions of Escherichia-Shigella, Enterococcus, Fusobacterium, and Veillonella increased significantly in PEDV-infected piglets, while those of short-chain fatty acid (SCFA)-producing bacteria (e.g., Rikenellaceae_RC9_gut_group, Butyricimonas, and Alistipes) underwent a decrease [21] . Some bacteria from Firmicutes and Bacteroidetes were enriched in healthy piglets, while some from Proteobacteria and Fusobacteria were more abundant in PEDV-infected groups. To better characterize the intestinal microbiomes of healthy versus PEDV-infected piglets, we recommend that future studies fully examine virome diversity using a larger sample size and metagenomic de novo sequencing of the gut microbial genome. Dynamic change of gut microbiota during porcine epidemic diarrhea virus infection in suckling piglets Changes in cecal microbiota community of suckling piglets infected with porcine epidemic diarrhea virus cache = ./cache/cord-275499-25dp6u68.txt txt = ./txt/cord-275499-25dp6u68.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-022633-fr55uod6 author = nan title = SAEM Abstracts, Plenary Session date = 2012-04-26 pages = extension = .txt mime = text/plain words = 147405 sentences = 8927 flesch = 54 summary = Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. cache = ./cache/cord-022633-fr55uod6.txt txt = ./txt/cord-022633-fr55uod6.txt === reduce.pl bib === id = cord-023346-8sqbqjm1 author = nan title = MONDAY: POSTERS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130043 sentences = 7330 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023346-8sqbqjm1.txt txt = ./txt/cord-023346-8sqbqjm1.txt === reduce.pl bib === === reduce.pl bib === id = cord-023354-f2ciho6o author = nan title = TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date = 2005-06-08 pages = extension = .txt mime = text/plain words = 130046 sentences = 7333 flesch = 54 summary = • enhancement of automation/computerisation; • process control to provide an 'error-free pathway'; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody 'combi' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas' disease infection (for retrieval of otherwise wasted blood); • European Union's in vitro diagnostics directive: this has caused some problems and reduced flexibility. cache = ./cache/cord-023354-f2ciho6o.txt txt = ./txt/cord-023354-f2ciho6o.txt === reduce.pl bib === id = cord-015021-pol2qm74 author = nan title = Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date = 1994 pages = extension = .txt mime = text/plain words = 162327 sentences = 9379 flesch = 50 summary = It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. cache = ./cache/cord-015021-pol2qm74.txt txt = ./txt/cord-015021-pol2qm74.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-280036-ev82fzly author = Almawly, J. title = Utility of halofuginone lactate for the prevention of natural cryptosporidiosis of calves, in the presence of co-infection with rotavirus and Salmonella Typhimurium date = 2013-10-18 pages = extension = .txt mime = text/plain words = 5769 sentences = 290 flesch = 53 summary = We performed a randomized controlled field trial of the efficacy of HL for the prevention of natural calf cryptosporidiosis, in the presence of co-infection with rotavirus and Salmonella Typhimurium. Motivated by the need of more data on the utility HL in the presence of co-infections with other pathogens, we performed a randomized controlled field trial of the anti-Cryptosporidium preventive efficacy of the compound in calves on a New Zealand farm enzootically infected with C. In addition to the analysis for Cryptosporidium, 23 fecal specimens taken haphazardly from the three treatment groups were analyzed for the presence of rotavirus, coronavirus, enterotoxigenic K99 + Escherichia coli (K99) and Salmonella spp. The calves in Group 3 (control Group) showed an oocyst shedding curve which was typical for natural cryptosporidiosis, with the majority of the animals becoming parasitologically positive by Day 8 and again negative by Day 20 (Tables 1 and 2) . cache = ./cache/cord-280036-ev82fzly.txt txt = ./txt/cord-280036-ev82fzly.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-285323-473d7zvg author = Jang, Hyesun title = Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus date = 2013-09-01 pages = extension = .txt mime = text/plain words = 4802 sentences = 228 flesch = 49 summary = The KIIa genotype (Kr/ADL110002/2011) induced clinical signs accompanied by the excessive production of pro-inflammatory cytokines and a higher viral load. In chickens infected with this isolate, simultaneous peaks in the viral copy number and cytokine production were observed at 7 dpi in the trachea and 9 d postinoculation in the kidney. In chickens infected with this isolate, simultaneous peaks in the viral copy number and cytokine production were observed at 7 dpi in the trachea and 9 d postinoculation in the kidney. In this study, we observed changes in the transcriptional levels of 3 pro-inflammatory cytokines that are known to be involved in the innate immune response in chickens (Hong et al., 2006; Davison et al., 2008) after inoculation with 2 IB isolates. On the other hand, an active infection of the ChVI genotype isolate kr/ADL120003/2012, which resulted in an increase in serum AGP level at 9 dpi (Table 3) , evoked only a limited range of pro-inflammatory responses. cache = ./cache/cord-285323-473d7zvg.txt txt = ./txt/cord-285323-473d7zvg.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023157-0lqlx2rv author = nan title = Poster Sessions date = 2013-04-18 pages = extension = .txt mime = text/plain words = 128430 sentences = 7726 flesch = 55 summary = The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. cache = ./cache/cord-023157-0lqlx2rv.txt txt = ./txt/cord-023157-0lqlx2rv.txt === reduce.pl bib === id = cord-023095-4dannjjm author = nan title = Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date = 2011-05-03 pages = extension = .txt mime = text/plain words = 134226 sentences = 6834 flesch = 51 summary = The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! cache = ./cache/cord-023095-4dannjjm.txt txt = ./txt/cord-023095-4dannjjm.txt === reduce.pl bib === id = cord-286779-si3qml42 author = Li, Hai-yan title = Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks date = 2020-06-04 pages = extension = .txt mime = text/plain words = 5077 sentences = 263 flesch = 48 summary = title: Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks Results obtained using 16S rRNA sequencing showed that infection with PDCoV strain HNZK-02 significantly altered the composition of chick gut microbiota, with the reduced abundance of Eisenbergiella and Anaerotruncus genera at 5 days post-inoculation (dpi) (P < 0.05), and an increased abundance of Alistipes genus at 17 dpi (P < 0.05). The expression of inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and interleukin-10) was increased in the cecum tissue and serum of the PDCoV HNZK-02–infected chicks when detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Further analysis showed significant correlation between bacterial genera and SCFAs or inflammatory cytokines expression in cecum of the PDCoV infected chicks. Three hundred and seventeen OTUs of the total gut microbial richness (375) were shared between the samples of mock and PDCoV HNZK-02 groups at 17 dpi (Figure 1 ). cache = ./cache/cord-286779-si3qml42.txt txt = ./txt/cord-286779-si3qml42.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-005814-ak5pq312 author = nan title = 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date = 1995 pages = extension = .txt mime = text/plain words = 179164 sentences = 12028 flesch = 56 summary = Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. cache = ./cache/cord-005814-ak5pq312.txt txt = ./txt/cord-005814-ak5pq312.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-296606-aizjzglo author = Guo, Tingting title = Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients date = 2020-07-30 pages = extension = .txt mime = text/plain words = 3893 sentences = 220 flesch = 60 summary = Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course. Conclusion: Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2(nd) week, followed by persistence of high levels and a prolonged median disease course. Therefore, the similar peak time, despite the higher initial CT score, when compared to the previous reports might have revealed the progressive nature of the disease at the absence of complicated treatments in the fangcang shelter hospitals, which was also evidenced by the slow decrease and persistent high CT scores after the 2 nd week in our study that was suggestive of the slow absorption of the COVID-19 lung lesions. cache = ./cache/cord-296606-aizjzglo.txt txt = ./txt/cord-296606-aizjzglo.txt === reduce.pl bib === id = cord-301687-wadf3c3i author = Li, Yan title = Association of “initial CT” findings with mortality in older patients with coronavirus disease 2019 (COVID-19) date = 2020-06-10 pages = extension = .txt mime = text/plain words = 3441 sentences = 184 flesch = 56 summary = Although radiation dose [7, 8] needs to be considered, chest CT as reported previously plays an important role in disease diagnosis, monitoring, severity stratification, and evaluation of treatment response in patients with COVID-19 [9, 10] , which goes beyond the ability of reverse transcription polymerase chain reaction (RT-PCR). In this single-center study, aiming to further identify the value of chest CT in clinical management of COVID-19, we evaluated the association of initial chest CT findings obtained at admission with severity and clinical outcomes in older patients with COVID-19. In the survival (n = 52) and death (n = 46) groups, the patients were sub-grouped based on the time interval between symptom onset and the "initial CT" scan: subgroup1 (interval ≤ 5 days), subgroup2 (interval between 6 and 10 days), and subgroup3 (interval > 10 days). In subgroup1 and subgroup2, patients underwent CT scans within 10 days after symptom onsets, where the mean score of "initial CT" was statistically higher in the death group than in the survival group. cache = ./cache/cord-301687-wadf3c3i.txt txt = ./txt/cord-301687-wadf3c3i.txt === reduce.pl bib === id = cord-299691-jton1oig author = Jové-Blanco, A. title = Video discharge instructions for pediatric gastroenteritis in an emergency department: a randomized, controlled trial date = 2020-10-08 pages = extension = .txt mime = text/plain words = 3433 sentences = 182 flesch = 51 summary = The aim was to evaluate if the addition of video discharge instructions (VDIs) to usual verbal information improved the comprehension of information provided to caregivers of patients who consult for acute gastroenteritis (AGE). This study was designed to evaluate if the addition of VDI to usual verbal information improved the comprehension of the information provided to caregivers of patients who consult in PED for acute gastroenteritis. In the first group of subjects (control group), caregivers received, after completing the test and prior to discharge, the usual verbal information and recommendations about AGE following the guidelines of the Spanish Society of Pediatric Emergencies [16] . This test also included questions about subsequent visits to either emergency units or outpatient pediatric clinics, satisfaction with the information (caregivers were asked to evaluate information in a score 0-10) and a question about whether they perceived video instructions as potentially useful tool or not. cache = ./cache/cord-299691-jton1oig.txt txt = ./txt/cord-299691-jton1oig.txt === reduce.pl bib === === reduce.pl bib === id = cord-303378-cfbvka30 author = Zhang, Shi-Jin title = Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia date = 2013-08-31 pages = extension = .txt mime = text/plain words = 2936 sentences = 147 flesch = 54 summary = Abstract Objective To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. On the basis of related studies, we illustrated the advantages of Haoqinqingdan decoction in treating this disease and its role in regulating immunity through the comparison between the high, medium and low dose Haoqinqingdan decoction groups and the ribavirin group, which would provide basis for differential traditional Chinese medicine treatment of upper respiratory viral infection [6] . cache = ./cache/cord-303378-cfbvka30.txt txt = ./txt/cord-303378-cfbvka30.txt === reduce.pl bib === id = cord-295987-die9jmbv author = Chabre, Yoann M. title = Design and Creativity in Synthesis of Multivalent Neoglycoconjugates date = 2010-04-08 pages = extension = .txt mime = text/plain words = 51109 sentences = 2401 flesch = 36 summary = PAP-a-Glc, poly(p-N-acryloylamidophenyl) a-glucopyranoside; PBS, phosphate buffered saline; PePO, pentaerythrityl phosphodiester oligomer; PET, photoinduced electron transfer; PITC, phenylisothiocyanate; PDT, photodynamic therapy; POSS, polyhedral oligosilsesquioxane; PMBC, peripheral blood mononuclear cells; PPI, polypropyleneimine; PS, photosensitizer; PVK, poly(methyl vinyl ketone); PyBOP, benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate; QSAR, quantitative structure-activity relationship; RCA 120 , Ricinus communis agglutinin; RGP, radial growth polymerization; SCVCP, self-condensing vinyl copolymerization; SEM, scanning electron microscopy; SHC, Sonogashira-Heck-Cassar cross coupling reactions; SLT, Shiga-like toxin; SLT-Iie, Shiga-like toxin II edema variant; SPG-Lac, schizophyllan bearing lactosides; SPR, surface plasmon resonance; SPS, solid-phase synthesis; STEC, Shiga toxigenic group of Escherichia coli; Stx, Shiga toxin; SWNT, single-walled nanotube; TBAF, tetra-n-butylammonium fluoride; TBAH, tetra-n-butylammonium hydroxide; TBTU, 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; TEM, transmission electron microscopy; TEMPO, 2,2,6,6-tetramethylpiperidine-1-oxyl; TF, Thomsen-Friedenreich antigen; TFA, trifluoroacetic acid; TGA, thermogravimetric analysis; THF, tetrahydrofuran; TRIS, tris(hydroxymethyl)aminomethane; VAA, Viscum album agglutinin; VT, verotoxin; VV-HRP, horseradish peroxidase-labeled plant lectin V. cache = ./cache/cord-295987-die9jmbv.txt txt = ./txt/cord-295987-die9jmbv.txt === reduce.pl bib === === reduce.pl bib === id = cord-305092-q4tlj1jd author = Lu, Jingjing title = Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China date = 2020-08-29 pages = extension = .txt mime = text/plain words = 1210 sentences = 74 flesch = 51 summary = title: Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China The aim of this study was to articulate the clinical characteristics of COVID‐19 and to reveal possible factors that may affect the persistent time of positive SARS‐CoV‐2 nucleic acid test, so as to identify which patients may deteriorate or have poor prognoses as early as possible. RESULTS: In this study, patients were divided into two groups based on whether their SARS‐CoV‐2 nucleic acid tests in respiratory specimens turn negative within (Group Rapid or Group R) or over (Group Slow or Group S) a week. Clinical characteristics of COVID-19 include the exposure history and typical systemic symptoms such as fever, cough, fatigue, decreased WBC and lymphocyte counts, and infiltration in both lower lobes on CT imaging. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study cache = ./cache/cord-305092-q4tlj1jd.txt txt = ./txt/cord-305092-q4tlj1jd.txt === reduce.pl bib === id = cord-302305-xr067v2n author = van Aalst, Jan title = Distinguishing knowledge-sharing, knowledge-construction, and knowledge-creation discourses date = 2009-06-20 pages = extension = .txt mime = text/plain words = 12911 sentences = 548 flesch = 49 summary = Knowledge construction involves a range of cognitive processes, including the use of explanation-seeking questions and problems, interpreting and evaluating new information, sharing, critiquing, and testing ideas at different levels (e.g., conjectures versus explanations that refer to concepts and/or causal mechanisms), and efforts to rise above current levels of explanation, including summarization, synthesis, and the creation of new concepts. Important progress has been made in this direction by the development of a system of principles that describe the socio-cognitive and socio-technological dynamics of knowledge creation, including collective cognitive responsibility for knowledge advancement, real ideas/authentic problems, epistemic agency, improvable ideas, rise-above, and constructive use of authoritative sources (Scardamalia 2002) . However, more work is needed to characterize the innovation ecology, such as by determining the social practices that make collaboration possible, the overall school culture, and the community's experience at knowledge creation and its long-term goals (Bielaczyc 2006; Truong 2008) . cache = ./cache/cord-302305-xr067v2n.txt txt = ./txt/cord-302305-xr067v2n.txt === reduce.pl bib === id = cord-302695-vyo3w2a4 author = Albertini, Laetitia title = Observational study on off-label use of tocilizumab in patients with severe COVID-19 date = 2020-09-10 pages = extension = .txt mime = text/plain words = 5025 sentences = 294 flesch = 62 summary = This is a single-centre observational cohort study of patients infected with COVID-19 and treated with TCZ between 6 April and 21 April 2020 at our general hospital. The criteria for receiving TCZ were: ► Hospitalised patients with a positive diagnosis of COVID-19 (by real-time PCR on nasopharyngeal swabs) ► Extensive bilateral lesions in the lungs ► Severe respiratory insufficiency needing oxygen supplementation (≥5 L) ► Clinical aggravation ► Increased CRP level ► No major contraindications to the drug. On day 14, in the TCZ group two patients required invasive ventilation compared with six in the control group (95% CI −0.4 to 0.05) (p=0.12) (figure 1). Indeed, on day 14 of follow-up, two patients in the TCZ group required invasive ventilation compared with six in the control group. The need for oxygen was reduced in the TCZ group despite the fact that this group had more severe clinical and radiological impairment of COVID-19 at the beginning of the study. cache = ./cache/cord-302695-vyo3w2a4.txt txt = ./txt/cord-302695-vyo3w2a4.txt === reduce.pl bib === id = cord-302079-pby3i6wq author = Deng, Yan title = Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study date = 2020-06-05 pages = extension = .txt mime = text/plain words = 3332 sentences = 193 flesch = 57 summary = title: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and we compare them with recovered patients (recovered group). CONCLUSIONS: Compared to the recovered group, more patients in the death group exhibited characteristics of advanced age, pre-existing comorbidities, dyspnea, oxygen saturation decrease, increased WBC count, decreased lymphocytes, and elevated CRP levels. In our study, we found no significant difference between the death and recovered group in the percentage of patients complicated with diabetes. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study cache = ./cache/cord-302079-pby3i6wq.txt txt = ./txt/cord-302079-pby3i6wq.txt === reduce.pl bib === id = cord-298534-1j8jkfn9 author = Zhu, H. title = Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study date = 2020-11-03 pages = extension = .txt mime = text/plain words = 3580 sentences = 205 flesch = 63 summary = title: Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study At present, there is no study to systematically analyse the features of hydroxybutyrate dehydrogenase (alpha-HBDH) in COVID-19 patients with different ages, clinical types and outcomes. Methods: Electronic medical records including demographics, clinical manifestation, alpha-HBDH test results and outcomes of 131 hospitalized COVID-19 patients, with confirmed result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, were extracted and analyzed. In this 46 study, we analyzed the changes of α-HBDH values of COVID-19 patients with different ages, clinical types and outcomes. The effects of α-HBDH, age and gender on the clinical type of COVID-19 patients were quantified by the optimal scale regression model, so as to 48 achieve the purpose of early judging the severity of the disease. 58 The symptom onset data was designed as the first day of disease, the abnormal percentage, median and quartile interval of α-HBDH in different 59 ages, outcomes and clinical types were calculated. cache = ./cache/cord-298534-1j8jkfn9.txt txt = ./txt/cord-298534-1j8jkfn9.txt === reduce.pl bib === id = cord-303807-fka9svzu author = Gerber, Michael A. title = Diagnosis and Treatment of Pharyngitis in Children date = 2005-05-28 pages = extension = .txt mime = text/plain words = 7181 sentences = 319 flesch = 37 summary = Guidelines from the Infectious Diseases Society of America (IDSA) [10] , American Academy of Pediatrics [11] , and American Heart Association [12] indicate that microbiologic confirmation (with a throat culture or RADT) is required for the diagnosis of group A beta-hemolytic streptococcal pharyngitis. Culture of a specimen obtained by throat swab on a sheep blood agar plate is the standard laboratory procedure for the microbiologic confirmation of the clinical diagnosis of acute group A beta-hemolytic streptococcal pharyngitis [16] . Currently, two of the most important issues regarding the use of RADTs for the diagnosis of group A beta-hemolytic streptococcal pharyngitis are the relative sensitivities of the different tests and whether any RADTs are sensitive enough to mitigate against the need to perform throat cultures in patients with negative test results. In addition, without the repeat isolation of the infecting strain of GAS (ie, true bacteriologic treatment failure), it is particularly difficult to determine the clinical significance of persistent or recurrent signs or symptoms suggesting group A beta-hemolytic streptococcal pharyngitis. cache = ./cache/cord-303807-fka9svzu.txt txt = ./txt/cord-303807-fka9svzu.txt === reduce.pl bib === id = cord-304208-jwlc8fxj author = Vagni, Monia title = Coping With COVID-19: Emergency Stress, Secondary Trauma and Self-Efficacy in Healthcare and Emergency Workers in Italy date = 2020-09-03 pages = extension = .txt mime = text/plain words = 8630 sentences = 360 flesch = 48 summary = Hence, this study explores the relationship between coping strategies used by healthcare and emergency workers in Italy to manage the stress factors related to the COVID-19 emergency, which may result in the risk of developing secondary trauma. As regards the stress that they experience, the literature clearly explains that healthcare and emergency workers who intervene in emergency situations are exposed to the risk of developing dysfunctional reactions that can be identified at different levelsphysical and/or physiological (e.g., psychosomatic disorders, sleep/wake cycle alterations, and sense of tiredness); emotional (e.g., irritability, nervousness, agitation, anger, low self-esteem, and guilt); cognitive (e.g., distractibility, sense of ineffectiveness, and negative anticipation of events); and relational (e.g., increase in conflicts within emergency teams and/or with their organization/institution, and social withdrawal)-and may also develop reactions from secondary trauma (Del Missier et al., 2008; Sbattella, 2009; Argentero and Setti, 2011; Fraccaroli and Balducci, 2011; Bellelli and Di Schiena, 2012; Walton et al., 2020) . cache = ./cache/cord-304208-jwlc8fxj.txt txt = ./txt/cord-304208-jwlc8fxj.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-300046-orlga9qf author = Gomes da Silva, J. title = Health literacy of inland population in the mitigation phase 3.2. of COVID-19's pandemic in Portugal - a descriptive cohort study date = 2020-05-14 pages = extension = .txt mime = text/plain words = 5399 sentences = 273 flesch = 48 summary = Globally, younger individuals, females, graduates and the Non-Risk Group presented higher relative frequencies of the correct answer along COVID-19's Questionnaire. However, three exceptions were observed: the Undergraduate Group and the Risk-Group had a high relative frequency stating that COVID-19 has a cure and in mentioning "Social Isolation" as an important preventive measure to adopt when compared to the Graduate Group and the Non-Risk Group, respectively. Males have higher relative frequency in answering the correct number of SNS24 and in stating that children can get sick and transmit the infection by SARS-CoV-2 when compared to females ( Table 2 -Supplementary information). Nonparametric tests reveal a statistically significant association regarding variable "Age", "Gender" and "Risk Factor", with younger individuals, females and individuals from Risk-Group stating more often the correct answer. Nonparametric tests reveal a statistically significant association regarding variable "Gender" and "Risk Factor", with males and individuals from Non-Risk Group answering the correct number. cache = ./cache/cord-300046-orlga9qf.txt txt = ./txt/cord-300046-orlga9qf.txt === reduce.pl bib === id = cord-312497-6cd7dolj author = Mishra, Anurag title = Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Low- to Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study date = 2020-08-19 pages = extension = .txt mime = text/plain words = 2396 sentences = 160 flesch = 54 summary = title: Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Lowto Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study The current study compares GAL with conventional Laparoscopic surgeries [COL] for general surgical procedures METHODS: A single-centre, non-blinded randomized control trial [RCT] was conducted to evaluate non inferiority of GAL versus COL at a teaching hospital in New Delhi. The Gas Insufflation Less Laparoscopic Surgeries [GAL] offers a solution to the challenges associated with conventional laparoscopy [COL] . However, considering the ethical issues, we planned a non-inferiority study to compare GAL using Stan Laparoscopy Positioner device [SLP] (Fig 1) with conventional laparoscopy (COL) for general surgical procedures. In a paper form, data was recorded on demographics, clinical profile, operative times, vital signs, use of analgesia, efficiency, procedure safety, patient and surgeon satisfaction. cache = ./cache/cord-312497-6cd7dolj.txt txt = ./txt/cord-312497-6cd7dolj.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-312695-1uw8xcxw author = Sugiarto, Sarah title = Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis date = 2016-08-05 pages = extension = .txt mime = text/plain words = 8623 sentences = 370 flesch = 51 summary = In the present study we investigated whether the passive transfer of antibodies from Mhf-recovered cats to naïve recipient cats provided protection against bacteremia and clinical disease following homologous challenge with Mhf; moreover, we characterized the immune response in the recipient cats. The present study aimed to investigate whether the passive transfer of antibodies from Mhf-recovered to naïve recipient cats induced partial or complete protection against bacteremia and clinical disease following homologous challenge with Mhf. Different parameters addressing the humoral and cellular immune response were monitored in passively immunized and control cats. Our study demonstrated that the passive transfer of antibodies from Mhf-recovered to naïve SPF cats does not prevent infection, high bacterial loads and the development of clinical signs following homologous challenge with Mhf. The passively immunized and control cats showed no differences in the onset and extent of bacteremia and anemia during the course of Mhf infection. cache = ./cache/cord-312695-1uw8xcxw.txt txt = ./txt/cord-312695-1uw8xcxw.txt === reduce.pl bib === id = cord-317347-by8albr9 author = van Ginkel, Frederik W. title = Age-dependent immune responses and immune protection after avian coronavirus vaccination date = 2015-05-28 pages = extension = .txt mime = text/plain words = 5792 sentences = 288 flesch = 53 summary = The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. Therefore, the ability of SPF chickens of different age to induce an IBV-specific antibody response and protect against challenge with an IBV field strain was measured. In order to measure IgG (IgY), IgA and IgM antibody levels in plasma and tears of chicken, an IBV-specific enzyme-linked immunosorbent assay (ELISA) was developed as previously described [20] . These data are consistent with a delay in the IgA plasma response to IBV in birds vaccinated at a younger age and a non-significant decline in mean IgA titers in the 1-day-old group. This would be consistent with a drop of presumably natural maternal IBV-specific IgM antibodies in these SPF chickens in the day 7 control age group. cache = ./cache/cord-317347-by8albr9.txt txt = ./txt/cord-317347-by8albr9.txt === reduce.pl bib === === reduce.pl bib === id = cord-324326-q014b5ym author = MURAKAMI, Makoto title = Lipoquality control by phospholipase A(2) enzymes date = 2017-11-10 pages = extension = .txt mime = text/plain words = 8260 sentences = 556 flesch = 45 summary = The phospholipase A(2) (PLA(2)) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. In terms of signal transduction, the phospholipase A 2 (PLA 2 ) reaction, which hydrolyzes the sn-2 position of phospholipids to yield fatty acids and lysophospholipids, has been considered to be of particular importance, since arachidonic acid (AA, C20:4), one of the polyunsaturated fatty acids (PUFAs) released from membrane phospholipids by PLA 2 , is metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) to lipid mediators including prostaglandins (PGs) and leukotrienes (LTs), which are often referred to as eicosanoids (Fig. 1) . 36) cPLA 2 C (group IVE PLA 2 ) exhibits a unique transacylase activity that transfers sn-1 fatty acid of PC to an amino residue of phosphatidylethanolamine (PE) to form N-acyl-PE, a precursor of the endocannabinoid lipid mediator N-acylethanolamine. cache = ./cache/cord-324326-q014b5ym.txt txt = ./txt/cord-324326-q014b5ym.txt === reduce.pl bib === id = cord-317344-wznzmssz author = Iannitti, T. title = Therapeutical use of probiotic formulations in clinical practice date = 2010-06-23 pages = extension = .txt mime = text/plain words = 24517 sentences = 1157 flesch = 44 summary = Now we are going to report some of the several studies involving the use of probiotic formulations to evaluate their efficacy for the treatment of allergic diseases basing on their ability to change either the composition and/or the metabolic activities of the microbiota or modulate immune system reactivity in a way that benefits health. One hundred and sixteen patients with IBS fulfilling the Rome II criteria were randomized in a parallel group, double-blind study to receive a placebo or a probiotic combination (1  10 10 cfu) once daily for four weeks. This randomized double-blind placebo-controlled study aimed at determining the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhea associated with antibiotic use and caused by Clostridium difficile. cache = ./cache/cord-317344-wznzmssz.txt txt = ./txt/cord-317344-wznzmssz.txt === reduce.pl bib === === reduce.pl bib === id = cord-329669-z3t7plvh author = Poulton, Kay title = A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients date = 2020-07-05 pages = extension = .txt mime = text/plain words = 2270 sentences = 124 flesch = 50 summary = HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. This study investigated HLA profiles of patients admitted with PCR-confirmed SARS-CoV-2 infection to identify any potential HLA bias which might indicate an impaired capacity to mount an effective immune response to the infection. All patients included in the study had previously been HLA typed to support transplantation and required hospital treatment for COVID-19 disease, indicating that their symptoms were severe, requiring clinical support or intervention. Statistical analysis was performed using MedCalc v19.3 (MedCalc Software) to compare frequencies of allele group carriage between the patient and control populations using Fisher's exact test. cache = ./cache/cord-329669-z3t7plvh.txt txt = ./txt/cord-329669-z3t7plvh.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-326747-zwp13awk author = Sever, Mustafa title = Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date = 2009-12-28 pages = extension = .txt mime = text/plain words = 3975 sentences = 234 flesch = 48 summary = In this paper, the socio-demographic and clinical characteristics of 39 accidentally exposed patients to chlorine gas are reported and different emergency treatment modalities are also discussed. In this paper, the social and demographic characteristics, clinical and laboratory findings of patients which have been accidentally exposed to chlorine gas due to chlorine tank explosion in Southeast of Turkey are reported. All hospitals' emergency departments (ED) medical records which explain above were retrospectively analyzed for evaluation of accidental chlorine exposure patients for year 2007. Guloglu et al [9] reported that they preferred and recommended humidified O 2 and ß agonist combination applications to be the supportive therapy in their study group because of trachea-bronchitis and broncho-constriction and/ or pulmonary edema and Reactive Airway Dysfunction Syndrome effects of chlorine gas. cache = ./cache/cord-326747-zwp13awk.txt txt = ./txt/cord-326747-zwp13awk.txt === reduce.pl bib === === reduce.pl bib === id = cord-326723-jiauk4fq author = Risalde, María A title = Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1 date = 2013-03-18 pages = extension = .txt mime = text/plain words = 5800 sentences = 283 flesch = 44 summary = The aim of this study was to clarify the mechanisms responsible for vascular changes occurring in the lungs of calves infected with bovine viral diarrhea virus (BVDV) and challenged later with bovine herpesvirus type 1 (BHV-1), evaluating the role of MΦs in the development of pathological lesions in this organ. Therefore, the aim of this study was to clarify the mechanisms responsible for ultrastructural and histopathological changes occurring in the lungs of calves pre-infected with BVDV and challenged later with BHV-1, as well as to analyze the role of MΦs in the appearance of the lesions. According to this, in the course of certain acute viral infections, platelets may be activated in vivo, leading to their degranulation, Figure 6 Pro-inflammatory cytokines in the lungs of calves with and without pre-existing BVDV challenged with BHV-1.1. cache = ./cache/cord-326723-jiauk4fq.txt txt = ./txt/cord-326723-jiauk4fq.txt === reduce.pl bib === id = cord-332735-vfnbs2jn author = Rebmann, Terri title = Infection preventionists' experience during the first months of the 2009 novel H1N1 influenza A pandemic date = 2009-12-31 pages = extension = .txt mime = text/plain words = 7904 sentences = 412 flesch = 56 summary = Reference materials needed for current and future pandemics Topics that require development into quick reference materials ranked by order of importance* Infection prevention guidance for nonacute care settings (ambulatory care, home health, physician offices, and others) Infection prevention guidance related to occupational health issues Evidence-based information for physician education Patient and family educational materials that are brief (eg, 1-page fact sheet) and available in multiple languages Patient management materials that are brief (eg, patient placement/isolation, PPE use, and others) Isolation precautions materials that are brief and simple: electronic format preferred Communication procedures when supplies run out Infection prevention guidance for pediatric facilities Resource management tool for supply allocation during a variety of events Screening tools and forms that are simple to use Algorithm/check list outlining steps of an outbreak investigation *Order of importance determined by the Nominal Group Method. cache = ./cache/cord-332735-vfnbs2jn.txt txt = ./txt/cord-332735-vfnbs2jn.txt === reduce.pl bib === id = cord-333334-90q1xkld author = Shengchen, D. title = Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial date = 2019-06-20 pages = extension = .txt mime = text/plain words = 3880 sentences = 182 flesch = 38 summary = title: Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial OBJECTIVES: The primary objective was to evaluate whether a molecular point-of-care test (POCT) for viral and atypical pathogens added to routine real-time PCR could reduce duration of intravenous antibiotics in hospitalized patients with lower respiratory tract infection (LRTI) compared with routine real-time PCR. The median and interquartile range of the primary outcome (duration of intravenous antibiotics) and secondary outcomes, including length of hospital stay, cost of intravenous antibiotics and cost of hospitalization, were calculated and the difference between intervention and control group was compared using the Wilcoxon rank-sum test. In conclusion, this study found the addition of molecular POCT testing to routine real-time PCR testing for respiratory viruses and atypical pathogens might help to reduce intravenous antibiotic use in LRTI patients without resulting in adverse outcomes. cache = ./cache/cord-333334-90q1xkld.txt txt = ./txt/cord-333334-90q1xkld.txt === reduce.pl bib === id = cord-329856-0m5mc320 author = Ahmad, Shandar title = Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date = 2020-06-04 pages = extension = .txt mime = text/plain words = 3763 sentences = 161 flesch = 54 summary = This paper reports an the analysis of age distribution patterns in six groups of Indian COVID-19 patient populations based on their likely geographical origin of infection viz. Altogether this study provides a scalable framework to estimate the source of infection in a new population of COVID-19 patients with unknown origin. Although the exact reasons of these dramatically different mortality rates and possible differences in affected age groups are not very well understood, it is widely recognized that the collection and presentation of accurate clinical data as well as elaborate epidemiological studies are needed in order to understand and control both current and future outbreaks such as COVID-19 [8, 9] . However, despite these caveats, this study provides a framework to utilize rudimentary patient population profiles such as patient age distribution to segregate them in terms of source of infection, and potentially develop combative strategies informed by these differences. cache = ./cache/cord-329856-0m5mc320.txt txt = ./txt/cord-329856-0m5mc320.txt === reduce.pl bib === id = cord-333745-nwnt2tde author = Wang, Yi title = Clinical characteristics and laboratory indicator analysis of 67 COVID-19 pneumonia patients in Suzhou, China date = 2020-10-12 pages = extension = .txt mime = text/plain words = 4399 sentences = 209 flesch = 51 summary = RESULTS: The study found that fibrinogen (FIB) was increased in 45 (65.2%) patients, and when FIB reached a critical value of 4.805 g/L, the sensitivity and specificity、DA, helping to distinguish general and severe cases, were 100 and 14%、92.9%, respectively, which were significantly better than those for lymphocyte count and myoglobin. In a comparison of patients in Group A with patients in Group B, the lymphocyte count absolute value (L), myoglobin (MB) and fibrinogen of COVID-19 pneumonia patients in Group A were significantly higher than those in Group B, with statistically significant differences (P ≤ 0.001) ( Table 4 ). Laboratory data showed that the WBC, N%, and CRP in Group B COVID-19 pneumonia patients were significantly higher than those of Group A patients, and the differences were statistically significant (P < 0.05). cache = ./cache/cord-333745-nwnt2tde.txt txt = ./txt/cord-333745-nwnt2tde.txt === reduce.pl bib === id = cord-331270-12zx0o2p author = Rico, Timóteo Matthies title = Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date = 2020-09-30 pages = extension = .txt mime = text/plain words = 5886 sentences = 290 flesch = 50 summary = title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial All text messages were sent to the intervention group patients in an automated and tailored way by our app called cHEmotHErApp. Side effects experienced by patients were verified using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30). In our previous study, we showed the acceptance and perception of cancer patients undergoing chemotherapy on an outpatient basis receiving daily text messages about prevention and managing side effects, as well as emotional support [30] . To our knowledge, the present study is the first clinical trial employing text messaging (SMS) with preventative advice and side effect management tips sent to cancer patients in outpatient chemotherapy. cache = ./cache/cord-331270-12zx0o2p.txt txt = ./txt/cord-331270-12zx0o2p.txt === reduce.pl bib === id = cord-342381-i63r6los author = Wu, Huiyue title = Design and development of an immersive virtual reality news application: a case study of the SARS event date = 2020-09-17 pages = extension = .txt mime = text/plain words = 9052 sentences = 435 flesch = 48 summary = For example, virtual reality technology has raised new requirements for the traditional news production process [14, 28, 45] , and the change of perspective caused by the disappearance of the physical screen and the appearance of interactive elements brings a new challenge to the narrative frame of journalism [13] . 3 Regarding narrative frame, the production of VR news is moving away from the linear and planned storytelling structure adopted by traditional news: In immersive VR news, the audience can not only understand the whole news event from an omniscient perspective (e.g., Kiya) 4 but also participate in the news story as bystanders (e.g., Use of Force) 5 or even become the protagonist to experience the feelings of the parties involved (e.g., Across the Line). cache = ./cache/cord-342381-i63r6los.txt txt = ./txt/cord-342381-i63r6los.txt === reduce.pl bib === id = cord-337644-aobdzwpx author = Pianta, L. title = Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date = 2020-05-24 pages = extension = .txt mime = text/plain words = 1742 sentences = 94 flesch = 53 summary = CONCLUSIONS: Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation. Therefore, considering these antiviral properties and that the upper airways are the main site of SARS-CoV-2 entry and replication, we have explored the use of this historical therapy in early-stage cases of COVID-19 by evaluating patients who were administered a disinfecting formulation of acetic acid as an intranasal aerosol. Patients treated with off-label hydroxychloroquine and lopinavir/ritonavir, the standard treatment prescribed at that time, were included in group 1, whereas group 2 was composed of patients treated with hydroxychloroquine only, combined with acetic acid nasal disinfectant at a 0.34% concentration. Acetic acid disinfection could not only improve the clinical course of COVID-19, but also reduce viral load in the airway and in the droplets exhaled by infected individuals. cache = ./cache/cord-337644-aobdzwpx.txt txt = ./txt/cord-337644-aobdzwpx.txt === reduce.pl bib === id = cord-341397-gl8xzzdv author = Bhavani, Sivasubramanium V. title = Novel Temperature Trajectory Subphenotypes in COVID-19 date = 2020-07-21 pages = extension = .txt mime = text/plain words = 1395 sentences = 93 flesch = 44 summary = In contrast to other common viral infections, COVID-19 presents unique challenges with high rates of hypoxemic respiratory failure, hyperinflammatory cytokine storm, coagulation abnormalities, and cardiac and renal dysfunction 2, 3 . We have previously published a novel method of identifying subphenotypes in hospitalized patients with all-cause infection using longitudinal body temperature measurements 6 . We hypothesize that using a similar approach specific to COVID-19 patients would identify subphenotypes with unique clinical characteristics and inflammatory and coagulation abnormalities. The primary outcome was 30-day inpatient mortality, which was modeled on subphenotype using Cox regression analysis, controlling for demographics, comorbidities, and severity of illness. The high mortality rate seen in Group 1 and the organ dysfunction seen in Group 4 suggest that both subphenotypes have a dysregulated response to COVID-19. In conclusion, we found four distinct subphenotypes of COVID-19 patients with markedly different clinical characteristics and mortality rates. cache = ./cache/cord-341397-gl8xzzdv.txt txt = ./txt/cord-341397-gl8xzzdv.txt === reduce.pl bib === id = cord-343418-519vkzci author = Li, Hao title = Study on the Performance Degradation of Sandstone under Acidification date = 2020-10-21 pages = extension = .txt mime = text/plain words = 3993 sentences = 210 flesch = 52 summary = X-ray diffraction qualitative analysis of the composition and concentration of ions shows that the formation of white precipitates is citric acid and Mg promotes the conversion of amorphous calcium carbonate to high-crystallinity calcite, forming a white precipitate. Due to the influence of the Corona Virus Disease 2019 (COVID-19), the research period was extended to 93 days, and it was unexpectedly concluded that the citric acid action promoted the precipitation of regular carbonate in the sandstone, resulting in calcium crystals, and an experimental analysis of the reasons for precipitation. Group 5 shows a relatively high ion content, indicating that hydrochloric acid and acetic acid both react with minerals in the sandstone, although the cores used in groups 4 and 7 are the most damaged due to the formation of precipitated substances by weak acids. cache = ./cache/cord-343418-519vkzci.txt txt = ./txt/cord-343418-519vkzci.txt === reduce.pl bib === id = cord-336192-5uxq5xrs author = Alavi, Maryam title = Coordination, cooperation, and creativity within harm reduction networks in Iran: COVID-19 prevention and control among people who use drugs date = 2020-08-17 pages = extension = .txt mime = text/plain words = 3077 sentences = 128 flesch = 35 summary = These platforms provided an accessible space to discuss critical issues, including COVID-19 policy updates, scientific information and education, and service provision among peer-support workers and people attending community-based drop-in centres, homeless shelters, and mobile and outreach services. Direct care services for people who use drugs Between March 15 and April 13, the Working Group coordinated distribution of COVID-19 prevention equipment and education booklets, personal items, food, and water among 2577 people attending 20 community-based drop-in centres, 18 homeless shelters, and eight mobile and 27 outreach services (visiting 87 street-based drug markets) in four provinces. Working group policy advocacy Violation of physical distancing by PWUD and homeless people in Tehran in early April marked the beginning of a campaign by several government organisations, led by factions within the state Drug Control Headquarters, proposing swift capture and hold of these individuals in designated shelters for the duration of the pandemic. cache = ./cache/cord-336192-5uxq5xrs.txt txt = ./txt/cord-336192-5uxq5xrs.txt === reduce.pl bib === id = cord-344121-k58c0jf3 author = Lundgren, A.-L. title = Neurological disease and encephalitis in cats experimentally infected with Borna disease virus date = 1997 pages = extension = .txt mime = text/plain words = 6161 sentences = 340 flesch = 52 summary = Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD. Of the cats in group II (cats inoculated with feline BDV), cat 6 had a few antigen-containing neurons and glial cells in the laterobasal temporal cortex, close to a region with several adventitial cuffs. cache = ./cache/cord-344121-k58c0jf3.txt txt = ./txt/cord-344121-k58c0jf3.txt === reduce.pl bib === id = cord-347960-vl5zhxyh author = Giallonardo, Vincenzo title = The Impact of Quarantine and Physical Distancing Following COVID-19 on Mental Health: Study Protocol of a Multicentric Italian Population Trial date = 2020-06-05 pages = extension = .txt mime = text/plain words = 6319 sentences = 282 flesch = 43 summary = The present study has been developed with the aims to: a) evaluate the impact of COVID-19 pandemic and its containment measures on mental health of the Italian population; b) to identify the main areas to be targeted by supportive long-term interventions for the different categories of people exposed to the pandemic. The survey includes the following self-reported questionnaires: the General Health Questionnaire -12 items (GHQ-12) (31); the Depression, Anxiety and Stress Scale -21 Items (DASS-21) (32); the Obsessive-Compulsive Inventory -Revised (OCI-R) (33); the Insomnia Severity Index (34) ; the Severity-of-Acute-Stress-Symptoms-Adult (35); the Suicidal Ideation Attributes Scale (SIDAS) (36); the Impact of Event Scale -6 items (37); the UCLA loneliness scale -short version (38) ; the Brief COPE (39); the Post Traumatic Growth Inventory short form (40) ; the Connor-Davidson Resilience Scaleshort form (41) ; the Multidimensional Scale of Perceived social support (42); the Pattern of Care Schedule (PCS)-modified version (43); the Maslach Burnout Inventory (only for health professionals) (44) . cache = ./cache/cord-347960-vl5zhxyh.txt txt = ./txt/cord-347960-vl5zhxyh.txt === reduce.pl bib === id = cord-339705-x8l3zgfd author = Patil, Vijaykumar title = An association between fingerprint patterns with blood group and lifestyle based diseases: a review date = 2020-08-18 pages = extension = .txt mime = text/plain words = 19191 sentences = 980 flesch = 52 summary = Due to the immense potential of fingerprints as an effective method of identification, the present research paper tries to investigate the problem of blood group identification and analysis of diseases those arises with aging like hypertension, type 2-diabetes and arthritis from a fingerprint by analyzing their patterns correlation with blood group and age of an individual. The fingerprint having basic four categories which are loop, whorl, arch and composites but also there are more than 100 interleaved ridge and valleys which explore unique characteristics of an individual which will help to design Deep Neural Network or Convolutional Neural Network (CNN) which predict blood group and common clinical diseases like hypertension, type 2-diabetes and arthritis. From the present investigation, the accompanying ends are drawn: (1) Loops are the most regularly discovered fingerprint pattern and arches are minimal normal in the two guys and females and furthermore in "ABO" blood groups. cache = ./cache/cord-339705-x8l3zgfd.txt txt = ./txt/cord-339705-x8l3zgfd.txt === reduce.pl bib === id = cord-342391-arp07mck author = Magiorkinis, G. title = Phylogenetic analysis of the full‐length SARS‐CoV sequences: Evidence for phylogenetic discordance in three genomic regions date = 2004-09-14 pages = extension = .txt mime = text/plain words = 1901 sentences = 81 flesch = 49 summary = Evidence based on Bayesian scanning plots and phylogenetic analysis using maximum likelihood (ML) and Bayesian methods indicates that SARS‐CoV, for the largest part of the genome (∼80%), is more closely related to Group II coronaviruses sequences, whereas in three regions in the ORF1ab gene it shows no apparent similarity to any of the previously characterized groups of coronaviruses. Bayesian scanning and subsequent phylogenetic analysis revealed that the SARS-CoV sequence was related more closely to Group II than the other two groups in most of its genome (e.g., at the region spanning amino acid positions 4309-5612 in reference to the murine hepatitis virus ORF1ab gene) (Fig. 1) . This clustering was supported by high quartet puzzling support values and high posterior probabilities under various substitution models, thus suggesting that 80% of the SARS-CoV genomic sequence is related more closely to coronaviruses Group II than any other members of this family. cache = ./cache/cord-342391-arp07mck.txt txt = ./txt/cord-342391-arp07mck.txt === reduce.pl bib === id = cord-342210-r8vxz5vu author = Mukherjee, Pranab K. title = Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections date = 2017-01-14 pages = extension = .txt mime = text/plain words = 4853 sentences = 247 flesch = 49 summary = We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. In the current study, we evaluated the safety and effectiveness of ARMS-I, a novel intra-oral formulation in the prevention of URIs in a randomized, double-blind, placebo-controlled proof-of-concept clinical trial in healthy adults. cache = ./cache/cord-342210-r8vxz5vu.txt txt = ./txt/cord-342210-r8vxz5vu.txt === reduce.pl bib === id = cord-353256-7nfklun9 author = Eroglu‐Ertugrul, Nesibe Gevher title = The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date = 2019-11-22 pages = extension = .txt mime = text/plain words = 3097 sentences = 178 flesch = 39 summary = OBJECTIVES: To demonstrate the value of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) when determining causes of lung infection in immunocompromised children; to investigate differences in causes and radiological features of lung infections following bone marrow transplantation (BMT) compared to other immunosuppressive conditions; to evaluate the reliability of radiological findings when predicting the pathogen. The purpose of the study was to demonstrate the value of FB and BAL in determining the cause of lung infections that develop in immunocompromised children, to investigate differences between the causes and radiological features of lung infections following BMT in comparison to other immunosuppressive conditions and to evaluate the reliability of radiological findings for predicting the causative pathogen. When all of the patients were considered together, a significant association was determined between the presence of viral pathogens (including CMV) and the radiological findings of interstitial infiltration and/or a ground-glass appearance (P = .003). cache = ./cache/cord-353256-7nfklun9.txt txt = ./txt/cord-353256-7nfklun9.txt === reduce.pl bib === id = cord-344411-lkgcxjya author = Huang, Qiqi title = The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens date = 2017-06-01 pages = extension = .txt mime = text/plain words = 5331 sentences = 265 flesch = 52 summary = title: The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens Abstract To examine the relationship of impairments of the liver and kidney with viral load after nephropathogenic infectious bronchitis virus (NIBV) infection in embryonic chickens, 120 specific-pathogen-free Leghorn embryonated chicken eggs were randomly divided into two groups (infected and control), with three replicates per group and 20 eggs in each replicate. This study attempted to infect embryonic chickens with NIBV and determine the plasma liver and kidney function indices and the tissue viral loads and to explore the relationships of the impairments in the liver and kidney with viral load. Our study demonstrated that liver and kidney damage were strongly related to the viral loads of the tissues following nephropathogenic infectious bronchitis virus infection in embryonic chickens. cache = ./cache/cord-344411-lkgcxjya.txt txt = ./txt/cord-344411-lkgcxjya.txt === reduce.pl bib === id = cord-335975-m6lkrehi author = nan title = Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date = 2018-02-05 pages = extension = .txt mime = text/plain words = 89374 sentences = 5327 flesch = 52 summary = A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. cache = ./cache/cord-335975-m6lkrehi.txt txt = ./txt/cord-335975-m6lkrehi.txt === reduce.pl bib === id = cord-348785-f67amppy author = Kapicibaşi, Hasan Oğuz title = Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model date = 2020-07-13 pages = extension = .txt mime = text/plain words = 2693 sentences = 171 flesch = 50 summary = PURPOSE: This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Based on the known positive and negative effects of ozone, in our study we aimed to assess the effect of two different doses of ozone therapy added to antibiotic treatment in an experimental sepsis model induced with Escherichia coli on the histopathologic findings observed in the inflammatory process in the lungs. In an experimental necrotizing pancreatitis model, ozone therapy was seen to be more effective to reduce oxidative stress levels, tissue injury and bacterial translocation rates compared to hyperbaric oxygen treatment 30 . Data obtained as a result of our study lead to the consideration that ozone therapy administered in addition to antibiotherapy may cause negative effects on lung tissue damaged due to sepsis. cache = ./cache/cord-348785-f67amppy.txt txt = ./txt/cord-348785-f67amppy.txt === reduce.pl bib === id = cord-355190-ytdw1d5v author = Mok, Chi Chiu title = Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date = 2020-09-11 pages = extension = .txt mime = text/plain words = 3763 sentences = 181 flesch = 50 summary = Organ damage as assessed by the Systemic Lupus International Collaborating Clinics (SLICC) damage index (SDI) and causes of death in the first 10 years of SLE onset was compared between the two groups. Cox regression showed that the age of SLE onset and damage score accrued at 10 years, but not the time period in which SLE was diagnosed, were significantly associated with mortality. Organ damage, mortality, and causes of death in the first 10 years of SLE diagnosis were also compared between the two groups. Covariates included in the model were age of SLE onset, sex, SDI score, renal involvement, ever use of hydroxychloroquine (HCQ) within 10 years of diagnosis, and time period in which patients were diagnosed. Long-term survival of southern Chinese patients with systemic lupus erythematosus: a prospective study of all age-groups Factors associated with damage accrual in patients with systemic lupus erythematosus with no clinical or serological disease activity: a multicentre cohort study cache = ./cache/cord-355190-ytdw1d5v.txt txt = ./txt/cord-355190-ytdw1d5v.txt === reduce.pl bib === id = cord-349720-2lxab3u2 author = Qin, Ling title = Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits date = 2015-05-15 pages = extension = .txt mime = text/plain words = 9960 sentences = 525 flesch = 52 summary = Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after surgical core-decompression (CD) to prevent femoral head collapse in a bipedal SAON animal model using emu (a large flightless bird). In conclusion, both efficacy and mechanistic studies show the potential of a bioactive composite porous P/T scaffold incorporating icaritin to enhance bone defect repair after surgical CD and prevent femoral head collapse in a bipedal SAON emu model. Applying a recently established bipedal emu SAON model with femoral head collapse similar to that typically observed in patients [23] , this study was designed to test the ability of our unique PLGA/ TCP/icaritin scaffold to enhance bone defect repair within a bone tunnel after surgical CD and to prevent femoral head collapse. cache = ./cache/cord-349720-2lxab3u2.txt txt = ./txt/cord-349720-2lxab3u2.txt === reduce.pl bib === id = cord-009997-oecpqf1j author = nan title = 2018 ASPHO ABSTRACTS date = 2018-03-31 pages = extension = .txt mime = text/plain words = 182060 sentences = 10342 flesch = 48 summary = Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher's Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children's Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. cache = ./cache/cord-009997-oecpqf1j.txt txt = ./txt/cord-009997-oecpqf1j.txt === reduce.pl bib === id = cord-355038-o2hr5mox author = nan title = Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date = 2020-02-11 pages = extension = .txt mime = text/plain words = 102485 sentences = 7028 flesch = 52 summary = Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). cache = ./cache/cord-355038-o2hr5mox.txt txt = ./txt/cord-355038-o2hr5mox.txt === reduce.pl bib === id = cord-341063-3rqnu5bu author = nan title = 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date = 2018-03-29 pages = extension = .txt mime = text/plain words = 98602 sentences = 6494 flesch = 52 summary = Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. cache = ./cache/cord-341063-3rqnu5bu.txt txt = ./txt/cord-341063-3rqnu5bu.txt === reduce.pl bib === id = cord-015354-yknwveyz author = nan title = Abstracts_Poster presentations date = 2007-09-18 pages = extension = .txt mime = text/plain words = 221428 sentences = 13119 flesch = 54 summary = Material and Methods: Fourteen individuals (mean age 47±19y range 21-75y; 4W, 10M; including 10 volunteers and 4 patients with angiographically proved CAD) underwent dynamic PET imaging studies (21 frames) at rest and during adenosine stress (0.14mg/kg/min for 6 min) after injection of 1100MBq of 82Rb (Discovery LS, GEMS). Methods:Twenty-nine patients (21 males,8 females;62±11 yrs) with recent AMI were studied.Within 6 days after AMI, the patients were performed Tl-201 R-RD perfusion SPECT using 4 mCi activity.CMR was carried out 5-20 minutes after 0,15 mmol/kg of iv.Gadobutrol injection.Myocardial perfusion and contrast enhancement was analyzed using a 17 segment model.Myocardial perfusion was scored in Tl-201 SPECT as follows:0=normal (70%-100% maximal myocardial activity(mma), 1= 69-50% mma, 2= 49-30% mma ,3=29-10% mma and 4=<10% mma ;Myocardial contrast enhancement on CMR images was graded as:0=no contrast enhancement, 1=hyperenhancement of 0-25% of the wall thickness(WT) 2=hyperenhancement of 26-50 % of the WT, 3=hyperenhancement of 51-75 % of WT and 4=hyperenhancement of 76-100 % of WT.In CMR the existence of microvascular obstruction(MO) was also evaluated.Total segment scores(TSS) in R,RD and CMR for each patient were calculated by summing of 17 segment score values. cache = ./cache/cord-015354-yknwveyz.txt txt = ./txt/cord-015354-yknwveyz.txt === reduce.pl bib === id = cord-015324-y44sfr0c author = nan title = Scientific Programme date = 2007-09-01 pages = extension = .txt mime = text/plain words = 197618 sentences = 12774 flesch = 53 summary = In order to further validate this approach, we performed a prospective randomized open-label multicenter trial in 41 low-risk pediatric renal transplant recipients (12 f, 29 m; mean age 10.1 yrs; range, 3.4 to 17.8) on CsA (target trough level 100-200 ng/ml), MMF (1200 mg/m 2 per day) and methylprednisolone (3) (4) mg/m 2 per day), who were randomly assigned >1 year posttransplant to continue steroids or to withdraw over a period of 3 months. We evaluated MMF in 15 children with LN, 11 F/4 M, mean age: 12.4±3.9 yrs, proteinuria >3 g/day, decreased C3 and increased anti-dsDNA serum levels, normal renal function. Patients and methods: 91 children and adolescents (60 male, 31 female, mean age at transplantation 9.7±5.2 years) with stable renal function and observation period exceeding 6 months were included. cache = ./cache/cord-015324-y44sfr0c.txt txt = ./txt/cord-015324-y44sfr0c.txt === reduce.pl bib === id = cord-010092-uftc8inx author = nan title = Abstract of 29th Regional Congress of the ISBT date = 2019-06-07 pages = extension = .txt mime = text/plain words = 233304 sentences = 13171 flesch = 54 summary = Prospective testing of blood donations in endemic areas of the U.S. revealed 0.38% of donors were positive for Babesia DNA or antibodies (Moritz, NEJM, 2016) Aims: -To report results of ongoing Babesia clinical trial -To explain significance of Babesia as a TT infection Methods: In cobas â Babesia for use on the cobas â 6800/8800 Systems, is a qualitative polymerase chain reaction nucleic acid amplification test, developed to detect in whole blood (WB) donor samples the 4 Babesia species that cause human disease: B. In sensitivity analyses, there were two discrepant results for HIV testing, three for HCV, and five for anti-HBc. Summary/Conclusions: Elecsys â infectious disease parameters on the cobas e 801 analyser demonstrate high specificity/sensitivity for screening first-time blood donor samples, with similar clinical performance to other commercially available assays. cache = ./cache/cord-010092-uftc8inx.txt txt = ./txt/cord-010092-uftc8inx.txt === reduce.pl bib === id = cord-022940-atbjwpo5 author = nan title = Poster Sessions date = 2016-09-07 pages = extension = .txt mime = text/plain words = 241182 sentences = 12746 flesch = 47 summary = We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. cache = ./cache/cord-022940-atbjwpo5.txt txt = ./txt/cord-022940-atbjwpo5.txt === reduce.pl bib === id = cord-005453-4057qib7 author = nan title = The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date = 2019-07-03 pages = extension = .txt mime = text/plain words = 275771 sentences = 16876 flesch = 56 summary = To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. cache = ./cache/cord-005453-4057qib7.txt txt = ./txt/cord-005453-4057qib7.txt ===== Reducing email addresses cord-005646-xhx9pzhj cord-014538-6a2pviol cord-022973-soaz8b74 cord-000977-ka4261wc cord-014794-yppi30a0 cord-280064-rz8cglyt cord-286479-p9d78t6v cord-335975-m6lkrehi cord-355038-o2hr5mox Creating transaction Updating adr table ===== Reducing keywords cord-001236-cgiok0ce cord-004091-gex0zvoa cord-003024-17f1evh3 cord-003673-u7711eb4 cord-003825-tkqxb1ql cord-003913-jr9hj0bs cord-004373-nmnssoeb cord-006578-wv3wc0ct cord-005379-5x4deimg cord-004342-9uok77wb cord-001809-azb7nie3 cord-002774-tpqsjjet cord-009797-8mdie73v cord-007580-qwh8ei60 cord-010501-kd95xvsg cord-010390-lc22hp3o cord-006987-1hf8vyhz cord-013263-xw611i8k cord-006984-x1r99rlm cord-009962-k3opc553 cord-010530-w8ir0e07 cord-014868-kg96uvpi cord-006864-t5qsjyfi cord-012537-49v45di6 cord-006391-esnsa4u5 cord-011147-55whf8md cord-005777-6rvfsx4p cord-013444-5aei9kaz cord-007367-e31zhty6 cord-009969-ln91qfg4 cord-010305-z5c7zgp7 cord-003532-lcgeingz cord-012518-ncrdwtdg cord-005646-xhx9pzhj cord-005816-i54q5gsu cord-014670-e31g8lns cord-014538-6a2pviol cord-005881-oswgjaxz cord-015082-l629n8is cord-014996-p6q0f37c cord-011062-ukz4hnmy cord-014516-r59usk02 cord-016559-tqd7m2i1 cord-018813-9hoksa86 cord-015126-cyhcbk1j cord-017067-19eawrjt cord-014533-6qfecv5h cord-005497-w81ysjf9 cord-005105-twsy61oq cord-005727-li8pwigg cord-022879-j6cecioe cord-015024-2xzc0uc5 cord-016842-sow7k53m cord-006854-o2e5na78 cord-010980-sizuef1v cord-015372-76xvzvdg cord-014464-m5n250r2 cord-014527-nvzfpntu cord-022643-2j559muh cord-006849-vgjz74ts cord-022973-soaz8b74 cord-000083-3p81yr4n cord-026983-36n7bm3j cord-021419-nypnib0h cord-024461-xo75855r cord-022281-xn0cf33a cord-032657-1egdwe26 cord-023186-gqltd6u0 cord-023225-5quigar4 cord-026493-z2hthkgy cord-032410-g546hez9 cord-015368-a0qz4tb9 cord-024698-jrnw1i07 cord-023311-7wqdlha4 cord-023017-k6edtg58 cord-023134-y665agnh cord-030277-x9zvx3fp cord-048469-xa9a5p0q cord-022653-qa1uph35 cord-015306-us58wwmp cord-034714-6e37yylk cord-035024-kx9jfssi cord-209697-bfc4h4b3 cord-193497-qqrhvlm5 cord-032979-jle66lmn cord-000977-ka4261wc cord-234996-hah19vmk cord-253308-wgseqk4t cord-259128-s27086aj cord-103538-vh6ma7k7 cord-259996-uhrhsrky cord-014794-yppi30a0 cord-261163-n9tp9nx7 cord-009567-osstpum6 cord-266597-v5glur2c cord-256165-cc3ph5e5 cord-103779-qobzttqa cord-264607-5vnaifi6 cord-262716-hea84shy cord-239632-dyvhzvmm cord-261073-s0qpiovr cord-260272-645g3to1 cord-270727-2dd3b7di cord-266722-qfn2dc1q cord-274396-l611eisi cord-270210-gfy2ytg5 cord-271106-srym2kh4 cord-023364-ut56gczm cord-272497-ww9o1kjr cord-273839-oasgagpc cord-270998-1adloi3o cord-261380-xms5su6w cord-274121-3w6kc0c9 cord-274497-tqceazdp cord-022650-phsr10jp cord-274563-jimw6skv cord-280055-5iwo6tlb cord-019347-tj3ye1mx cord-275499-25dp6u68 cord-275162-2239dk45 cord-281309-c9y7m5do cord-278032-27ikx97x cord-022633-fr55uod6 cord-023346-8sqbqjm1 cord-276288-upv2o8f6 cord-023354-f2ciho6o cord-280064-rz8cglyt cord-015021-pol2qm74 cord-280097-f7ky61ds cord-275427-00bwhaga cord-282879-28nhr1hv cord-280036-ev82fzly cord-278802-bverdk5w cord-284266-tbndldhr cord-285136-07jcccv9 cord-284804-6i5zbmm1 cord-284301-fg3hk94b cord-283177-qwinggg4 cord-285323-473d7zvg cord-284635-79cgct71 cord-286779-si3qml42 cord-023157-0lqlx2rv cord-288528-f6oz6zyz cord-023095-4dannjjm cord-286479-p9d78t6v cord-287431-bq0675h1 cord-286539-3sr4djft cord-288552-7lp07v5i cord-005814-ak5pq312 cord-289865-36ai2xgy cord-294175-nu6q2ddu cord-298569-174bzxdh cord-294839-qxn22td0 cord-290465-tvegf0kt cord-296606-aizjzglo cord-301687-wadf3c3i cord-290256-mkfg7nar cord-299691-jton1oig cord-298582-25qn9d15 cord-297138-t8b3914h cord-303378-cfbvka30 cord-295987-die9jmbv cord-305092-q4tlj1jd cord-302305-xr067v2n cord-302079-pby3i6wq cord-302695-vyo3w2a4 cord-298534-1j8jkfn9 cord-303807-fka9svzu cord-304208-jwlc8fxj cord-298931-n1se3ajb cord-318248-y2vkpuv3 cord-300046-orlga9qf cord-312497-6cd7dolj cord-299881-weptfpa2 cord-317410-hc06yo32 cord-317347-by8albr9 cord-312695-1uw8xcxw cord-322789-9elfpx0e cord-324326-q014b5ym cord-317344-wznzmssz cord-306145-5uf0hj6a cord-326431-42luhd4s cord-329669-z3t7plvh cord-326747-zwp13awk cord-329468-vjsurl60 cord-323906-ro078y52 cord-326723-jiauk4fq cord-332735-vfnbs2jn cord-333745-nwnt2tde cord-331270-12zx0o2p cord-333334-90q1xkld cord-329856-0m5mc320 cord-341397-gl8xzzdv cord-337644-aobdzwpx cord-342381-i63r6los cord-336192-5uxq5xrs cord-347960-vl5zhxyh cord-339705-x8l3zgfd cord-343418-519vkzci cord-342391-arp07mck cord-344121-k58c0jf3 cord-342210-r8vxz5vu cord-344411-lkgcxjya cord-353256-7nfklun9 cord-348785-f67amppy cord-335975-m6lkrehi cord-009997-oecpqf1j cord-349720-2lxab3u2 cord-355038-o2hr5mox cord-341063-3rqnu5bu cord-015354-yknwveyz cord-015324-y44sfr0c cord-010092-uftc8inx cord-022940-atbjwpo5 cord-005453-4057qib7 cord-355190-ytdw1d5v Creating transaction Updating wrd table ===== Reducing urls cord-003913-jr9hj0bs cord-004091-gex0zvoa cord-005379-5x4deimg cord-004342-9uok77wb cord-003024-17f1evh3 cord-009797-8mdie73v cord-011147-55whf8md cord-005777-6rvfsx4p cord-009969-ln91qfg4 cord-013444-5aei9kaz cord-011062-ukz4hnmy cord-014996-p6q0f37c cord-017067-19eawrjt cord-014533-6qfecv5h cord-010980-sizuef1v cord-006854-o2e5na78 cord-016842-sow7k53m cord-014464-m5n250r2 cord-022973-soaz8b74 cord-006849-vgjz74ts cord-032410-g546hez9 cord-030277-x9zvx3fp cord-253308-wgseqk4t cord-261163-n9tp9nx7 cord-270210-gfy2ytg5 cord-274396-l611eisi cord-256165-cc3ph5e5 cord-023364-ut56gczm cord-273839-oasgagpc cord-275499-25dp6u68 cord-023346-8sqbqjm1 cord-023354-f2ciho6o cord-280064-rz8cglyt cord-285136-07jcccv9 cord-280036-ev82fzly cord-284804-6i5zbmm1 cord-285323-473d7zvg cord-286539-3sr4djft cord-297138-t8b3914h cord-305092-q4tlj1jd cord-298534-1j8jkfn9 cord-300046-orlga9qf cord-317347-by8albr9 cord-299881-weptfpa2 cord-322789-9elfpx0e cord-329669-z3t7plvh cord-329468-vjsurl60 cord-329856-0m5mc320 cord-333334-90q1xkld cord-331270-12zx0o2p cord-336192-5uxq5xrs cord-347960-vl5zhxyh cord-342210-r8vxz5vu cord-009997-oecpqf1j cord-349720-2lxab3u2 cord-015354-yknwveyz cord-010092-uftc8inx cord-022940-atbjwpo5 cord-005453-4057qib7 Creating transaction Updating url table ===== Reducing named entities cord-003913-jr9hj0bs cord-004342-9uok77wb cord-004091-gex0zvoa cord-003673-u7711eb4 cord-003825-tkqxb1ql cord-001236-cgiok0ce cord-004373-nmnssoeb cord-005379-5x4deimg cord-006578-wv3wc0ct cord-003024-17f1evh3 cord-001809-azb7nie3 cord-007580-qwh8ei60 cord-009797-8mdie73v cord-010501-kd95xvsg cord-010390-lc22hp3o cord-006987-1hf8vyhz cord-006984-x1r99rlm cord-002774-tpqsjjet cord-013263-xw611i8k cord-010530-w8ir0e07 cord-012537-49v45di6 cord-009962-k3opc553 cord-011147-55whf8md cord-014868-kg96uvpi cord-007367-e31zhty6 cord-013444-5aei9kaz cord-006864-t5qsjyfi cord-009969-ln91qfg4 cord-010305-z5c7zgp7 cord-006391-esnsa4u5 cord-005777-6rvfsx4p cord-012518-ncrdwtdg cord-014670-e31g8lns cord-018813-9hoksa86 cord-015082-l629n8is cord-016559-tqd7m2i1 cord-017067-19eawrjt cord-014538-6a2pviol cord-003532-lcgeingz cord-005646-xhx9pzhj cord-005816-i54q5gsu cord-005881-oswgjaxz cord-015126-cyhcbk1j cord-011062-ukz4hnmy cord-014996-p6q0f37c cord-022879-j6cecioe cord-014516-r59usk02 cord-016842-sow7k53m cord-022643-2j559muh cord-015372-76xvzvdg cord-022973-soaz8b74 cord-014533-6qfecv5h cord-026983-36n7bm3j cord-015024-2xzc0uc5 cord-005497-w81ysjf9 cord-021419-nypnib0h cord-005727-li8pwigg cord-005105-twsy61oq cord-022281-xn0cf33a cord-024461-xo75855r cord-032657-1egdwe26 cord-023186-gqltd6u0 cord-014464-m5n250r2 cord-010980-sizuef1v cord-006854-o2e5na78 cord-014527-nvzfpntu cord-032410-g546hez9 cord-026493-z2hthkgy cord-023311-7wqdlha4 cord-024698-jrnw1i07 cord-023134-y665agnh cord-015368-a0qz4tb9 cord-030277-x9zvx3fp cord-023225-5quigar4 cord-048469-xa9a5p0q cord-034714-6e37yylk cord-035024-kx9jfssi cord-193497-qqrhvlm5 cord-006849-vgjz74ts cord-000083-3p81yr4n cord-022653-qa1uph35 cord-209697-bfc4h4b3 cord-015306-us58wwmp cord-023017-k6edtg58 cord-032979-jle66lmn cord-234996-hah19vmk cord-103538-vh6ma7k7 cord-259996-uhrhsrky cord-253308-wgseqk4t cord-259128-s27086aj cord-261163-n9tp9nx7 cord-266597-v5glur2c cord-256165-cc3ph5e5 cord-264607-5vnaifi6 cord-239632-dyvhzvmm cord-262716-hea84shy cord-103779-qobzttqa cord-261073-s0qpiovr cord-270727-2dd3b7di cord-000977-ka4261wc cord-260272-645g3to1 cord-266722-qfn2dc1q cord-270210-gfy2ytg5 cord-274396-l611eisi cord-271106-srym2kh4 cord-261380-xms5su6w cord-270998-1adloi3o cord-272497-ww9o1kjr cord-274121-3w6kc0c9 cord-273839-oasgagpc cord-274563-jimw6skv cord-274497-tqceazdp cord-280055-5iwo6tlb cord-275499-25dp6u68 cord-275162-2239dk45 cord-278032-27ikx97x cord-281309-c9y7m5do cord-009567-osstpum6 cord-276288-upv2o8f6 cord-280064-rz8cglyt cord-280097-f7ky61ds cord-280036-ev82fzly cord-023364-ut56gczm cord-014794-yppi30a0 cord-275427-00bwhaga cord-282879-28nhr1hv cord-019347-tj3ye1mx cord-278802-bverdk5w cord-022650-phsr10jp cord-284266-tbndldhr cord-023346-8sqbqjm1 cord-284804-6i5zbmm1 cord-285136-07jcccv9 cord-023354-f2ciho6o cord-022633-fr55uod6 cord-283177-qwinggg4 cord-285323-473d7zvg cord-284301-fg3hk94b cord-284635-79cgct71 cord-288528-f6oz6zyz cord-286779-si3qml42 cord-286479-p9d78t6v cord-286539-3sr4djft cord-287431-bq0675h1 cord-288552-7lp07v5i cord-289865-36ai2xgy cord-294175-nu6q2ddu cord-298569-174bzxdh cord-294839-qxn22td0 cord-290465-tvegf0kt cord-290256-mkfg7nar cord-296606-aizjzglo cord-301687-wadf3c3i cord-299691-jton1oig cord-298582-25qn9d15 cord-297138-t8b3914h cord-023157-0lqlx2rv cord-303378-cfbvka30 cord-305092-q4tlj1jd cord-295987-die9jmbv cord-302305-xr067v2n cord-015021-pol2qm74 cord-023095-4dannjjm cord-302079-pby3i6wq cord-302695-vyo3w2a4 cord-298534-1j8jkfn9 cord-303807-fka9svzu cord-304208-jwlc8fxj cord-298931-n1se3ajb cord-318248-y2vkpuv3 cord-300046-orlga9qf cord-312497-6cd7dolj cord-005814-ak5pq312 cord-299881-weptfpa2 cord-317410-hc06yo32 cord-317347-by8albr9 cord-312695-1uw8xcxw cord-322789-9elfpx0e cord-324326-q014b5ym cord-317344-wznzmssz cord-329669-z3t7plvh cord-326431-42luhd4s cord-329468-vjsurl60 cord-326747-zwp13awk cord-326723-jiauk4fq cord-323906-ro078y52 cord-332735-vfnbs2jn cord-306145-5uf0hj6a cord-333334-90q1xkld cord-333745-nwnt2tde cord-331270-12zx0o2p cord-329856-0m5mc320 cord-342381-i63r6los cord-337644-aobdzwpx cord-341397-gl8xzzdv cord-347960-vl5zhxyh cord-336192-5uxq5xrs cord-339705-x8l3zgfd cord-343418-519vkzci cord-344121-k58c0jf3 cord-342210-r8vxz5vu cord-353256-7nfklun9 cord-342391-arp07mck cord-344411-lkgcxjya cord-348785-f67amppy cord-349720-2lxab3u2 cord-355190-ytdw1d5v cord-335975-m6lkrehi cord-341063-3rqnu5bu cord-355038-o2hr5mox cord-009997-oecpqf1j cord-015354-yknwveyz cord-015324-y44sfr0c cord-010092-uftc8inx cord-022940-atbjwpo5 cord-005453-4057qib7 Creating transaction Updating ent table ===== Reducing parts of speech cord-004342-9uok77wb cord-010390-lc22hp3o cord-003825-tkqxb1ql cord-003024-17f1evh3 cord-004091-gex0zvoa cord-001236-cgiok0ce cord-003673-u7711eb4 cord-005379-5x4deimg cord-003913-jr9hj0bs cord-004373-nmnssoeb cord-006578-wv3wc0ct cord-001809-azb7nie3 cord-009797-8mdie73v cord-007580-qwh8ei60 cord-010530-w8ir0e07 cord-013263-xw611i8k cord-010501-kd95xvsg cord-009962-k3opc553 cord-006984-x1r99rlm cord-006987-1hf8vyhz cord-012537-49v45di6 cord-011147-55whf8md cord-014868-kg96uvpi cord-010305-z5c7zgp7 cord-013444-5aei9kaz cord-007367-e31zhty6 cord-009969-ln91qfg4 cord-018813-9hoksa86 cord-022879-j6cecioe cord-016842-sow7k53m cord-022973-soaz8b74 cord-017067-19eawrjt cord-022643-2j559muh cord-024461-xo75855r cord-026983-36n7bm3j cord-032657-1egdwe26 cord-016559-tqd7m2i1 cord-022281-xn0cf33a cord-032410-g546hez9 cord-026493-z2hthkgy cord-024698-jrnw1i07 cord-030277-x9zvx3fp cord-014670-e31g8lns cord-035024-kx9jfssi cord-048469-xa9a5p0q cord-034714-6e37yylk cord-209697-bfc4h4b3 cord-015082-l629n8is cord-032979-jle66lmn cord-234996-hah19vmk cord-193497-qqrhvlm5 cord-021419-nypnib0h cord-006864-t5qsjyfi cord-012518-ncrdwtdg cord-023186-gqltd6u0 cord-023311-7wqdlha4 cord-253308-wgseqk4t cord-259128-s27086aj cord-103538-vh6ma7k7 cord-259996-uhrhsrky cord-261163-n9tp9nx7 cord-266597-v5glur2c cord-256165-cc3ph5e5 cord-264607-5vnaifi6 cord-262716-hea84shy cord-006391-esnsa4u5 cord-239632-dyvhzvmm cord-260272-645g3to1 cord-261073-s0qpiovr cord-270727-2dd3b7di cord-270210-gfy2ytg5 cord-266722-qfn2dc1q cord-261380-xms5su6w cord-271106-srym2kh4 cord-274396-l611eisi cord-270998-1adloi3o cord-273839-oasgagpc cord-023134-y665agnh cord-274121-3w6kc0c9 cord-274563-jimw6skv cord-274497-tqceazdp cord-015372-76xvzvdg cord-005777-6rvfsx4p cord-272497-ww9o1kjr cord-275162-2239dk45 cord-280055-5iwo6tlb cord-275499-25dp6u68 cord-278032-27ikx97x cord-014516-r59usk02 cord-281309-c9y7m5do cord-276288-upv2o8f6 cord-280064-rz8cglyt cord-280097-f7ky61ds cord-282879-28nhr1hv cord-280036-ev82fzly cord-285323-473d7zvg cord-284266-tbndldhr cord-278802-bverdk5w cord-014538-6a2pviol cord-284804-6i5zbmm1 cord-103779-qobzttqa cord-285136-07jcccv9 cord-284301-fg3hk94b cord-284635-79cgct71 cord-005881-oswgjaxz cord-286779-si3qml42 cord-015126-cyhcbk1j cord-288528-f6oz6zyz cord-287431-bq0675h1 cord-286479-p9d78t6v cord-286539-3sr4djft cord-275427-00bwhaga cord-288552-7lp07v5i cord-002774-tpqsjjet cord-289865-36ai2xgy cord-283177-qwinggg4 cord-294175-nu6q2ddu cord-003532-lcgeingz cord-298569-174bzxdh cord-022653-qa1uph35 cord-290465-tvegf0kt cord-294839-qxn22td0 cord-290256-mkfg7nar cord-005816-i54q5gsu cord-005646-xhx9pzhj cord-296606-aizjzglo cord-301687-wadf3c3i cord-299691-jton1oig cord-298582-25qn9d15 cord-297138-t8b3914h cord-303378-cfbvka30 cord-305092-q4tlj1jd cord-302079-pby3i6wq cord-302305-xr067v2n cord-023225-5quigar4 cord-023017-k6edtg58 cord-302695-vyo3w2a4 cord-303807-fka9svzu cord-298534-1j8jkfn9 cord-304208-jwlc8fxj cord-015306-us58wwmp cord-014996-p6q0f37c cord-298931-n1se3ajb cord-318248-y2vkpuv3 cord-300046-orlga9qf cord-015024-2xzc0uc5 cord-312497-6cd7dolj cord-299881-weptfpa2 cord-011062-ukz4hnmy cord-317347-by8albr9 cord-317410-hc06yo32 cord-014527-nvzfpntu cord-312695-1uw8xcxw cord-322789-9elfpx0e cord-014533-6qfecv5h cord-306145-5uf0hj6a cord-324326-q014b5ym cord-326431-42luhd4s cord-326747-zwp13awk cord-329468-vjsurl60 cord-005727-li8pwigg cord-329669-z3t7plvh cord-323906-ro078y52 cord-326723-jiauk4fq cord-332735-vfnbs2jn cord-333334-90q1xkld cord-333745-nwnt2tde cord-329856-0m5mc320 cord-331270-12zx0o2p cord-342381-i63r6los cord-337644-aobdzwpx cord-343418-519vkzci cord-341397-gl8xzzdv cord-344121-k58c0jf3 cord-336192-5uxq5xrs cord-347960-vl5zhxyh cord-342391-arp07mck cord-344411-lkgcxjya cord-353256-7nfklun9 cord-342210-r8vxz5vu cord-355190-ytdw1d5v cord-348785-f67amppy cord-014464-m5n250r2 cord-015368-a0qz4tb9 cord-317344-wznzmssz cord-349720-2lxab3u2 cord-339705-x8l3zgfd cord-005497-w81ysjf9 cord-295987-die9jmbv cord-000083-3p81yr4n cord-010980-sizuef1v cord-019347-tj3ye1mx cord-005105-twsy61oq cord-022650-phsr10jp cord-023364-ut56gczm cord-009567-osstpum6 cord-000977-ka4261wc cord-023354-f2ciho6o cord-006854-o2e5na78 cord-014794-yppi30a0 cord-023095-4dannjjm cord-023157-0lqlx2rv cord-335975-m6lkrehi cord-023346-8sqbqjm1 cord-022633-fr55uod6 cord-341063-3rqnu5bu cord-355038-o2hr5mox cord-015021-pol2qm74 cord-006849-vgjz74ts cord-005814-ak5pq312 cord-009997-oecpqf1j cord-015324-y44sfr0c cord-015354-yknwveyz cord-010092-uftc8inx cord-022940-atbjwpo5 cord-005453-4057qib7 Creating transaction Updating pos table Building ./etc/reader.txt cord-005453-4057qib7 cord-009997-oecpqf1j cord-005105-twsy61oq cord-005497-w81ysjf9 cord-005814-ak5pq312 cord-005727-li8pwigg number of items: 216 sum of words: 6,604,304 average size in words: 41,020 average readability score: 50 nouns: patients; group; study; results; blood; treatment; methods; groups; cells; years; time; data; cases; age; patient; disease; cell; analysis; days; levels; risk; mortality; therapy; conclusion; day; rate; control; surgery; care; months; children; use; level; studies; infection; hospital; number; expression; test; ml; conclusions; period; diagnosis; serum; case; system; effect; method; response; factors verbs: using; shows; compared; included; performed; increasing; associated; following; found; evaluate; receive; treat; reported; based; determine; identify; assessed; observed; reducing; developed; presented; measured; undergoing; decreased; related; improve; obtain; requiring; suggest; provides; induced; detected; investigate; considered; analyzed; aimed; according; studying; occur; demonstrated; remains; give; collected; make; leading; indicated; need; describe; cause; reveals adjectives: clinical; significant; high; higher; positive; different; non; acute; mean; first; low; severe; renal; normal; lower; specific; total; negative; surgical; anti; median; respiratory; early; medical; common; new; important; cardiac; chronic; primary; old; similar; post; single; patient; human; present; laparoscopic; pulmonary; major; postoperative; effective; small; standard; average; healthy; initial; possible; long; pre adverbs: also; significantly; however; respectively; well; therefore; statistically; even; often; previously; especially; still; prior; critically; less; recently; highly; frequently; clinically; later; retrospectively; furthermore; mainly; currently; moreover; least; usually; commonly; alone; particularly; approximately; successfully; prospectively; potentially; finally; now; first; almost; relatively; directly; together; immediately; additionally; widely; rather; subsequently; initially; randomly; n't; strongly pronouns: we; our; it; their; its; they; them; i; he; she; his; her; us; one; you; itself; themselves; my; your; me; him; himself; s; ourselves; mg; ours; em; iga1; herself; oneself; p210bcr; myself; mrs; itma; theirs; hmsh2; rrt; r348; p24ag; imagej; igg4; y€; yourself; upa; u; thee; t2dm; siil-33; puc; pm.sec- proper nouns: ICU; mg; CT; C; II; Group; T; University; Hospital; AE; A; ±; CI; B; kg; ED; PCR; HCV; L; HSCT; Fig; M.; M; S.; HBV; January; C.; D; Care; IV; MRI; S; HIV; ARDS; RBC; BMI; TNF; Medical; LPS; RNA; Background; AKI; HLA; Department; Health; I; CMV; E.; L.; IL-6 keywords: group; patient; study; result; method; hospital; conclusion; university; icu; day; high; introduction; treatment; covid-19; care; cell; year; pcr; level; mortality; blood; january; case; ards; intensive; hiv; apache; aki; sofa; dna; vap; test; mean; increase; hcv; background; ecmo; disease; crp; table; rna; objective; hla; department; child; tbi; surgery; sepsis; score; peep one topic; one dimension: patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944362/ titles(s): Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning three topics; one dimension: patients; patients; blood file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103177/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913621/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167970/ titles(s): 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 | Research Communications of the 25th ECVIM‐CA Congress | Posters five topics; three dimensions: patients group study; patients results study; group groups cells; patients dogs study; blood transfusion patients file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101731/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103177/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167970/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913621/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169338/ titles(s): Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China | 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 | Posters | Research Communications of the 25th ECVIM‐CA Congress | EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS Type: cord title: keyword-group-cord date: 2021-05-24 time: 23:57 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:group ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-006987-1hf8vyhz author: Abass, Ahmed O title: Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults date: 2017-10-05 words: 6779.0 sentences: 320.0 pages: flesch: 46.0 cache: ./cache/cord-006987-1hf8vyhz.txt txt: ./txt/cord-006987-1hf8vyhz.txt summary: title: Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection. Thus, the current study was designed to investigate the effects of propolis supplementation on controlling the oxidative stress induced by paraquat injection to turkeys. In addition, growth performance of turkey birds was obtained under propolis supplementation in order to test whether it has the ability to reverse the negative effects of oxidative stress induced by paraquat. The current study also demonstrates that dietary propolis supplementation significantly increased plasma T 3 concentration in the PR+PQ group compared to PQ group which, consequently, alleviated the negative effect of paraquat injection on the growth performance of turkey poults. abstract: Paraquat (PQ) is used as a herbicide in agriculture and causes oxidative and inflammatory damage to animal tissues. The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection. Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0.5 mL sterile saline for 7 days (PR group); while the control poults received a basal diet with a daily subcutaneous saline injection for 7 consecutive days (C group). The productive performance in the PQ group showed a significant (P < 0.05) reduction in the weight gain (WG) and feed intake (FI), and impaired feed conversion ratio (FCR). Propolis supplementation in the PR+PQ group significantly ameliorated the PQ effects on WG and FCR. Turkey poults of the PQ and PR+PQ groups had a significant augmentation in the blood malondialdehyde (MDA), tumor necrosis factor-α (TNFα), and corticosterone levels, and in contrast, a significant reduction in the triiodothyronine (T(3)), when compared to the C group. While propolis significantly reduced the MDA and corticosterone, and increased the T(3) levels in the PR+PQ group compared to the PQ group. Furthermore, the dietary PR supplementation significantly limited the PQ-suppressive effects on cell- and humoral-mediated immunity and lymphocyte proliferation of turkey poults. In addition, propolis supplementation in the PR and PR+PQ groups markedly reversed the PQ-induced DNA fragmentation and heat shock protein 70 (Hsp70) over-expression in blood cells. It can be concluded that PR could improve turkey immunity and performance, particularly under inflammation and oxidative stress induced by PQ exposure. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107162/ doi: 10.3382/ps/pex248 id: cord-322789-9elfpx0e author: Abbaspour Kasgari, Hamideh title: Evaluation of the efficacy of sofosbuvir plus daclatasvir in combination with ribavirin for hospitalized COVID-19 patients with moderate disease compared with standard care: a single-centre, randomized controlled trial date: 2020-08-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: New therapeutic options are urgently needed to tackle the novel coronavirus disease 2019 (COVID-19). Repurposing existing pharmaceuticals provides an immediate treatment opportunity. We assessed the efficacy of sofosbuvir and daclatasvir with ribavirin for treating patients with COVID-19. METHODS: This was a single-centre, randomized controlled trial in adults with moderate COVID-19 admitted to the Ghaem Shahr Razi Hospital in Mazandaran Province, Iran. Patients were randomly assigned to 400 mg sofosbuvir, 60 mg daclatasvir and 1200 mg ribavirin (intervention group) or to standard care (control group). The primary endpoint of this study was length of hospital stay. This study is registered by IRCT.ir under the ID: IRCT20200328046886N1. RESULTS: Between 20 March 2020 and 8 April 2020, 48 patients were recruited; 24 patients were randomly assigned to the intervention group and 24 to the control group. The median duration of hospital stay was 6 days in both groups (P = 0.398). The number of ICU admissions in the sofosbuvir/daclatasvir/ribavirin group was not significantly lower than the control group (0 versus 4, P = 0.109). There was no difference in the number of deaths between the groups (0 versus 3, P = 0.234). The cumulative incidence of recovery was higher in the sofosbuvir/daclatasvir/ribavirin arm (Gray’s P = 0.033). CONCLUSIONS: This randomized trial was too small to make definitive conclusions. There were trends in favour of the sofosbuvir/daclatasvir/ribavirin arm for recovery and lower death rates. However, there was an imbalance in the baseline characteristics between the arms. Larger randomized trials should be conducted to investigate this treatment further. url: https://www.ncbi.nlm.nih.gov/pubmed/32812025/ doi: 10.1093/jac/dkaa332 id: cord-004091-gex0zvoa author: Abdulkareem, Shaheen A. title: Risk perception and behavioral change during epidemics: Comparing models of individual and collective learning date: 2020-01-06 words: 8379.0 sentences: 432.0 pages: flesch: 50.0 cache: ./cache/cord-004091-gex0zvoa.txt txt: ./txt/cord-004091-gex0zvoa.txt summary: For this study, we ran eight ABMs to test various combinations of individual and group learning, using different information sources-with or without interactions among agents-as factors in the BNs. We investigate the extent to which the epidemic spreads, depending on these different learning approaches regarding risk perception and coping decisions. The empirically-driven BNs model a two-stage decision process of people facing a disease risk: learning to update risk perceptions (threat appraisal, BN1 in Fig 1) and making decisions about how to adapt their behavior during the epidemic (coping appraisal, BN2 in Fig 1) . To evaluate the impact of individual and social intelligence on agents'' learning processes regarding risk perception and coping appraisal and the resulting patterns of disease spread, we used four output measures: disease diffusion, risk perception, spatial patterns, and model performance. Finally, in M7, where household agents learned risk perception in decentralized groups and learned to cope individually, 2,911 infected cases were recorded (Table 3) . abstract: Modern societies are exposed to a myriad of risks ranging from disease to natural hazards and technological disruptions. Exploring how the awareness of risk spreads and how it triggers a diffusion of coping strategies is prominent in the research agenda of various domains. It requires a deep understanding of how individuals perceive risks and communicate about the effectiveness of protective measures, highlighting learning and social interaction as the core mechanisms driving such processes. Methodological approaches that range from purely physics-based diffusion models to data-driven environmental methods rely on agent-based modeling to accommodate context-dependent learning and social interactions in a diffusion process. Mixing agent-based modeling with data-driven machine learning has become popularity. However, little attention has been paid to the role of intelligent learning in risk appraisal and protective decisions, whether used in an individual or a collective process. The differences between collective learning and individual learning have not been sufficiently explored in diffusion modeling in general and in agent-based models of socio-environmental systems in particular. To address this research gap, we explored the implications of intelligent learning on the gradient from individual to collective learning, using an agent-based model enhanced by machine learning. Our simulation experiments showed that individual intelligent judgement about risks and the selection of coping strategies by groups with majority votes were outperformed by leader-based groups and even individuals deciding alone. Social interactions appeared essential for both individual learning and group learning. The choice of how to represent social learning in an agent-based model could be driven by existing cultural and social norms prevalent in a modeled society. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944362/ doi: 10.1371/journal.pone.0226483 id: cord-329856-0m5mc320 author: Ahmad, Shandar title: Potential of age distribution profiles for the prediction of COVID-19 infection origin in a patient group date: 2020-06-04 words: 3763.0 sentences: 161.0 pages: flesch: 54.0 cache: ./cache/cord-329856-0m5mc320.txt txt: ./txt/cord-329856-0m5mc320.txt summary: This paper reports an the analysis of age distribution patterns in six groups of Indian COVID-19 patient populations based on their likely geographical origin of infection viz. Altogether this study provides a scalable framework to estimate the source of infection in a new population of COVID-19 patients with unknown origin. Although the exact reasons of these dramatically different mortality rates and possible differences in affected age groups are not very well understood, it is widely recognized that the collection and presentation of accurate clinical data as well as elaborate epidemiological studies are needed in order to understand and control both current and future outbreaks such as COVID-19 [8, 9] . However, despite these caveats, this study provides a framework to utilize rudimentary patient population profiles such as patient age distribution to segregate them in terms of source of infection, and potentially develop combative strategies informed by these differences. abstract: The COVID-19 pandemic is a serious and global public health concern. It is now well known that COVID-19 cases may result in mild symptoms leading to patient recovery. However, severity of infection, fatality rates, and treatment responses across different countries, age groups, and demographic groups suggest that the nature of infection is diverse, and a timely investigation of the same is needed for evolving sound treatment and preventive strategies. This paper reports an the analysis of age distribution patterns in six groups of Indian COVID-19 patient populations based on their likely geographical origin of infection viz. the United Kingdom, North America, the European Union, the Middle East, and Asian countries. It was observed that patient groups stratified in this way had a distinct age profile and that some of these groups e.g. patient groups from Asia, the European Union, and the United Kingdom formed a different cluster than those from North America, the Middle East, and other regions. Patient age profiles of a population were found to be highly predictive of the group they belong to, and there are indications of their distinct recovery and fatality rates across gender. Altogether this study provides a scalable framework to estimate the source of infection in a new population of COVID-19 patients with unknown origin. It is also concluded that greater public availability of age and other demographic profile details of patients may be helpful in gaining robust insights into COVID-19 infection origins. Datasets and scripts used in this work are shared at http://covid.sciwhylab.org. url: https://www.ncbi.nlm.nih.gov/pubmed/32835072/ doi: 10.1016/j.imu.2020.100364 id: cord-272497-ww9o1kjr author: Al-Anzi, Bader S. title: An Overview of the World Current and Future Assessment of Novel COVID-19 Trajectory, Impact, and Potential Preventive Strategies at Healthcare Settings date: 2020-09-25 words: 8892.0 sentences: 396.0 pages: flesch: 58.0 cache: ./cache/cord-272497-ww9o1kjr.txt txt: ./txt/cord-272497-ww9o1kjr.txt summary: The current study aims to assess the trajectory of the recent pandemic due to the COVID-19 outbreak utilizing a new splitting methodology of the selected countries into two groups and developing regression-based and SIR-based statistical models and tools that depict the actual recorded data of COVID-19. Figure 1 was generated to show the recorded daily total infected cases of the world over a certain timeframe (22 January 2020 until present), which shows that the COVID-19 disease started to increase slowly until about 11 March and then accelerated at a faster speed afterwards. Figure 1 was generated to show the recorded daily total infected cases of the world over a certain timeframe (22 January 2020 until present), which shows that the COVID-19 disease started to increase slowly until about 11 March and then accelerated at a faster speed afterwards. abstract: This study is an overview of the current and future trajectory, as well as the impact of the novel Coronavirus (COVID-19) in the world and selected countries including the state of Kuwait. The selected countries were divided into two groups: Group A (China, Switzerland, and Ireland) and Group B (USA, Brazil, and India) based on their outbreak containment of this virus. Then, the actual data for each country were fitted to a regression model utilizing the excel solver software to assess the current and future trajectory of novel COVID-19 and its impact. In addition, the data were fitted using the Susceptible–Infected–Recovered (SIR) Model. The Group A trajectory showed an “S” shape trend that suited a logistic function with r(2) > 0.97, which is an indication of the outbreak control. The SIR models for the countries in this group showed that they passed the expected 99% end of pandemic dates. Group B, however, exhibited a continuous increase of the total COVID-19 new cases, that best suited an exponential growth model with r(2) > 0.97, which meant that the outbreak is still uncontrolled. The SIR models for the countries in this group showed that they are still relatively far away from reaching the expected 97% end of pandemic dates. The maximum death percentage varied from 3.3% (India) to 7.2% with USA recording the highest death percentage, which is virtually equal to the maximum death percentage of the world (7.3%). The power of the exponential model determines the severity of the country’s trajectory that ranged from 11 to 19 with the USA and Brazil having the highest values. The maximum impact of this COVID-19 pandemic occurred during the uncontrolled stage (2), which mainly depended on the deceptive stage (1). Further, some novel potential containment strategies are discussed. Results from both models showed that the Group A countries contained the outbreak, whereas the Group B countries still have not reached this stage yet. Early measures and containment strategies are imperative in suppressing the spread of COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32992809/ doi: 10.3390/ijerph17197016 id: cord-336192-5uxq5xrs author: Alavi, Maryam title: Coordination, cooperation, and creativity within harm reduction networks in Iran: COVID-19 prevention and control among people who use drugs date: 2020-08-17 words: 3077.0 sentences: 128.0 pages: flesch: 35.0 cache: ./cache/cord-336192-5uxq5xrs.txt txt: ./txt/cord-336192-5uxq5xrs.txt summary: These platforms provided an accessible space to discuss critical issues, including COVID-19 policy updates, scientific information and education, and service provision among peer-support workers and people attending community-based drop-in centres, homeless shelters, and mobile and outreach services. Direct care services for people who use drugs Between March 15 and April 13, the Working Group coordinated distribution of COVID-19 prevention equipment and education booklets, personal items, food, and water among 2577 people attending 20 community-based drop-in centres, 18 homeless shelters, and eight mobile and 27 outreach services (visiting 87 street-based drug markets) in four provinces. Working group policy advocacy Violation of physical distancing by PWUD and homeless people in Tehran in early April marked the beginning of a campaign by several government organisations, led by factions within the state Drug Control Headquarters, proposing swift capture and hold of these individuals in designated shelters for the duration of the pandemic. abstract: An unprecedented public health crisis confronts the world. Iran is among the hardest-hit countries, where effects of the COVID-19 pandemic are stretched across society and felt by the most marginalised people. Among people who use drugs, a comprehensive response to the crisis calls for broad collaboration, coordination, and creativity involving multiple government and non-government organisations. This commentary provides early insights into an unfolding experience, demonstrating the operational and policy impact of an initiative, bringing together a diverse array of harm reduction stakeholders to address the pandemic. In the context of lived experiences of social and economic marginalization, this initiative intends to lead efforts in developing an equitable response to the COVID-19 pandemic. url: https://doi.org/10.1016/j.drugpo.2020.102908 doi: 10.1016/j.drugpo.2020.102908 id: cord-302695-vyo3w2a4 author: Albertini, Laetitia title: Observational study on off-label use of tocilizumab in patients with severe COVID-19 date: 2020-09-10 words: 5025.0 sentences: 294.0 pages: flesch: 62.0 cache: ./cache/cord-302695-vyo3w2a4.txt txt: ./txt/cord-302695-vyo3w2a4.txt summary: This is a single-centre observational cohort study of patients infected with COVID-19 and treated with TCZ between 6 April and 21 April 2020 at our general hospital. The criteria for receiving TCZ were: ► Hospitalised patients with a positive diagnosis of COVID-19 (by real-time PCR on nasopharyngeal swabs) ► Extensive bilateral lesions in the lungs ► Severe respiratory insufficiency needing oxygen supplementation (≥5 L) ► Clinical aggravation ► Increased CRP level ► No major contraindications to the drug. On day 14, in the TCZ group two patients required invasive ventilation compared with six in the control group (95% CI −0.4 to 0.05) (p=0.12) (figure 1). Indeed, on day 14 of follow-up, two patients in the TCZ group required invasive ventilation compared with six in the control group. The need for oxygen was reduced in the TCZ group despite the fact that this group had more severe clinical and radiological impairment of COVID-19 at the beginning of the study. abstract: BACKGROUND: In December 2019 a novel coronavirus designated SARS-CoV-2 was identified, and the disease COVID-19 has caused many deaths. SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which can cause lung damage and lack of oxygen. Tocilizumab (TCZ) inhibits ligand binding to the IL-6 receptor and may be a potential treatment for the hyperinflammation symptoms of COVID-19. However, data regarding the efficacy of TCZ in COVID-19 are lacking. The rapid spread of the pandemic in France, especially in the Paris region, constrained us to the off-label use of TCZ in patients with severe clinical conditions. METHODS: A single-centre observational cohort study of 44 patients infected with COVID-19 was carried out between 6 April and 21 April 2020 in Groupe Hospitalier Intercommunal Le Raincy-Montfermeil (GHILRM). Twenty-two patients diagnosed with COVID-19 were treated with TCZ and were compared with 22 patients not treated with TCZ matched for age, gender and length of hospital stay for COVID-19. Respiratory rate and oxygen supplementation as well as laboratory parameters (such as C-reactive protein (CRP), aspartate aminotransferase and alanine aminotransferase) were collected at baseline and during 14 days of follow-up. Our primary objective was to assess the efficacy of TCZ on respiratory clinical conditions. FINDINGS: The average respiratory rate was lower in the TCZ group than in the control group (21.5 vs 25.5 breaths/min at day 14, 95% CI −7.5 to −0.4; p=0.03). Treated patients tended to be intubated less during the course of the disease (2/22 vs 6/22, 95% CI −0.4 to 0.1; p=0.12). In each group, 10 patients no longer required oxygen therapy. We found a significant decrease in CRP in treated patients on day 7 (p=0.04). TCZ caused cytolysis in more than half (14/22) of the patients but without clinical impact. INTERPRETATION: There was a significant difference in the respiratory rate on day 14 of follow-up, with a greater decrease observed in the treated group. Fewer patients required mechanical ventilation in the TCZ group, especially among patients with more extensive CT lung damage, than in the control group. The same number of patients were weaned off oxygen on day 14 in the two groups, while the patients in the TCZ group had more severe impairment at inclusion. We consider that TCZ showed significant control of the biological inflammatory syndrome, suggesting that it may limit the effect of the cytokine storm. Our study seems to indicate the efficacy of TCZ, particularly in patients with severe initial pulmonary impairment. Selecting the best candidates and the best timing for TCZ therapy needs to be determined in randomised clinical trials. url: https://www.ncbi.nlm.nih.gov/pubmed/32912961/ doi: 10.1136/ejhpharm-2020-002414 id: cord-034714-6e37yylk author: Alleg, Manel title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximab- than natalizumab-associated PML date: 2020-11-06 words: 3746.0 sentences: 170.0 pages: flesch: 37.0 cache: ./cache/cord-034714-6e37yylk.txt txt: ./txt/cord-034714-6e37yylk.txt summary: title: Progressive multifocal leukoencephalopathy: MRI findings in HIV-infected patients are closer to rituximabthan natalizumab-associated PML OBJECTIVES: To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. Inclusion criteria were (1) a "definite" PML diagnosis according to the American Academy of Neurology criteria [19] including clinical and imaging-compatible features and detection of JCV DNA in the cerebrospinal fluid or in brain tissue by polymerase chain reaction (PCR) or immunohistochemistry; (2) HIV-infected patients or patients treated with immunomodulatory or immunosuppressive drugs such as natalizumab or rituximab, possibly in association with other drugs and whatever the initial illness; and (3) consent was provided for in the hospital''s charter. This study aims to describe the MRI characteristics of PML associated with rituximab and natalizumab and in HIV infection while comparing imaging findings with the level of immunosuppression. abstract: OBJECTIVES: To compare brain MRI findings in progressive multifocal leukoencephalopathy (PML) associated to rituximab and natalizumab treatments and HIV infection. MATERIALS AND METHODS: In this retrospective, multicentric study, we analyzed brain MRI exams from 72 patients diagnosed with definite PML: 32 after natalizumab treatment, 20 after rituximab treatment, and 20 HIV patients. We compared T2- or FLAIR-weighted images, diffusion-weighted images, T2*-weighted images, and contrast enhancement features, as well as lesion distribution, especially gray matter involvement. RESULTS: The three PML entities affect U-fibers associated with low signal intensities on T2*-weighted sequences. Natalizumab-associated PML showed a punctuate microcystic appearance in or in the vicinity of the main PML lesions, a potential involvement of the cortex, and contrast enhancement. HIV and rituximab-associated PML showed only mild contrast enhancement, punctuate appearance, and cortical involvement. The CD4/CD8 ratio showed a trend to be higher in the natalizumab group, possibly mirroring a more efficient immune response. CONCLUSION: Imaging features of rituximab-associated PML are different from those of natalizumab-associated PML and are closer to those observed in HIV-associated PML. KEY POINTS: • Nowadays, PML is emerging as a complication of new effective therapies based on monoclonal antibodies. • Natalizumab-associated PML shows more inflammatory signs, a perivascular distribution “the milky way,” and more cortex involvement than rituximab- and HIV-associated PML. • MRI differences are probably related to higher levels of immunosuppression in HIV patients and those under rituximab therapy. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7644389/ doi: 10.1007/s00330-020-07362-y id: cord-280036-ev82fzly author: Almawly, J. title: Utility of halofuginone lactate for the prevention of natural cryptosporidiosis of calves, in the presence of co-infection with rotavirus and Salmonella Typhimurium date: 2013-10-18 words: 5769.0 sentences: 290.0 pages: flesch: 53.0 cache: ./cache/cord-280036-ev82fzly.txt txt: ./txt/cord-280036-ev82fzly.txt summary: We performed a randomized controlled field trial of the efficacy of HL for the prevention of natural calf cryptosporidiosis, in the presence of co-infection with rotavirus and Salmonella Typhimurium. Motivated by the need of more data on the utility HL in the presence of co-infections with other pathogens, we performed a randomized controlled field trial of the anti-Cryptosporidium preventive efficacy of the compound in calves on a New Zealand farm enzootically infected with C. In addition to the analysis for Cryptosporidium, 23 fecal specimens taken haphazardly from the three treatment groups were analyzed for the presence of rotavirus, coronavirus, enterotoxigenic K99 + Escherichia coli (K99) and Salmonella spp. The calves in Group 3 (control Group) showed an oocyst shedding curve which was typical for natural cryptosporidiosis, with the majority of the animals becoming parasitologically positive by Day 8 and again negative by Day 20 (Tables 1 and 2) . abstract: Halofuginone lactate (HL) is registered in several countries for the prevention of calf cryptosporidiosis, but the compound's utility in the presence of co-infection with other enteropathogens is not well understood. We performed a randomized controlled field trial of the efficacy of HL for the prevention of natural calf cryptosporidiosis, in the presence of co-infection with rotavirus and Salmonella Typhimurium. Newborn calves on one farm were sequentially enrolled and allocated to a full dose (n = 15), half dose (n = 15), or a placebo control group (n = 15), using a randomized block design. The Cryptosporidium oocysts in fecal specimens collected on Days 6, 8, 10, 14 and 20 were counted and the severity of the diarrhea was assessed using fecal consistency scores (solid, semisolid, or liquid). The oocyst numbers and fecal consistency scores were statistically compared between the groups. Ninety one percent of the calves shed Cryptosporidium parvum oocysts during the trial. The full dose group had a longer prepatent period than the control group, but no statistical difference in the number of oocysts was identified between the groups after controlling for the effects of sex and breed. The fecal consistency scores and mortality rates did not differ between the groups. These results indicated that the anti-Cryptosporidium activity and clinical benefit of HL were limited. It is concluded that in order to maximize the clinical efficacy of HL in the field, diagnostic efforts should aim to rule out the presence of other enteropathogens. url: https://www.ncbi.nlm.nih.gov/pubmed/23707392/ doi: 10.1016/j.vetpar.2013.04.029 id: cord-016842-sow7k53m author: An, Jisun title: Multidimensional Analysis of the News Consumption of Different Demographic Groups on a Nationwide Scale date: 2017-08-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Examining 103,133 news articles that are the most popular for different demographic groups in Daum News (the second most popular news portal in South Korea) during the whole year of 2015, we provided multi-level analyses of gender and age differences in news consumption. We measured such differences in four different levels: (1) by actual news items, (2) by section, (3) by topic, and (4) by subtopic. We characterized the news items at the four levels by using the computational techniques, which are topic modeling and the vector representation of words and news items. We found that differences in news reading behavior across different demographic groups are the most noticeable in subtopic level but neither section nor topic levels. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121259/ doi: 10.1007/978-3-319-67217-5_9 id: cord-275427-00bwhaga author: Aydogdu, Ugur title: The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis date: 2019-11-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts >10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely. url: https://www.ncbi.nlm.nih.gov/pubmed/32288211/ doi: 10.1016/j.smallrumres.2019.09.021 id: cord-009969-ln91qfg4 author: Bertolesi, Gabriel E. title: Plasticity for colour adaptation in vertebrates explained by the evolution of the genes pomc, pmch and pmchl date: 2019-03-10 words: 9270.0 sentences: 487.0 pages: flesch: 52.0 cache: ./cache/cord-009969-ln91qfg4.txt txt: ./txt/cord-009969-ln91qfg4.txt summary: We suggest an explanation for the differences in the mechanisms that evolved to regulate background adaptation by inferring ancestral relationships, and assessing associations with plastic colour change, the ability of α-MSH, MCH and MCHL peptides to be synthesized and secreted and to work as neuroendocrine hormones, as well as their effects on skin pigmentation. Interestingly, several species in this group lack the dual-hormonal mechanism, in that MCH/MCHL plasma levels but not α-MSH vary with background adaptation, including flounders (Verasper moseri and Platichthys flesus) (Gilham & Baker, 1984; Kang & Kim, 2013; Mizusawa et al., 2011) and tilapias from the genus Oreochromis (Nile and Mozambique) (Gröneveld, Balm, Martens et al., 1995a; Gröneveld, Balm, & Wendelaar Bonga, 1995b; van der Salm, Metz, Wendelaar Bonga, & Flik, 2005) . We used both the structure and presence of pomc, pmch and pmchl as a "genetic basis," alongside MCH/MCHL "hormonal status," to explain differences in the physiological mechanisms for background adaptation over evolution. abstract: Different camouflages work best with some background matching colour. Our understanding of the evolution of skin colour is based mainly on the genetics of pigmentation (“background matching”), with little known about the evolution of the neuroendocrine systems that facilitate “background adaptation” through colour phenotypic plasticity. To address the latter, we studied the evolution in vertebrates of three genes, pomc, pmch and pmchl, that code for α‐MSH and two melanin‐concentrating hormones (MCH and MCHL). These hormones induce either dispersion/aggregation or the synthesis of pigments. We find that α‐MSH is highly conserved during evolution, as is its role in dispersing/synthesizing pigments. Also conserved is the three‐exon pmch gene that encodes MCH, which participates in feeding behaviours. In contrast, pmchl (known previously as pmch), is a teleost‐specific intron‐less gene. Our data indicate that in zebrafish, pmchl‐expressing neurons extend axons to the pituitary, supportive of an MCHL hormonal role, whereas zebrafish and Xenopus pmch+ neurons send axons dorsally in the brain. The evolution of these genes and acquisition of hormonal status for MCHL explain different mechanisms used by vertebrates to background‐adapt. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167667/ doi: 10.1111/pcmr.12776 id: cord-341397-gl8xzzdv author: Bhavani, Sivasubramanium V. title: Novel Temperature Trajectory Subphenotypes in COVID-19 date: 2020-07-21 words: 1395.0 sentences: 93.0 pages: flesch: 44.0 cache: ./cache/cord-341397-gl8xzzdv.txt txt: ./txt/cord-341397-gl8xzzdv.txt summary: In contrast to other common viral infections, COVID-19 presents unique challenges with high rates of hypoxemic respiratory failure, hyperinflammatory cytokine storm, coagulation abnormalities, and cardiac and renal dysfunction 2, 3 . We have previously published a novel method of identifying subphenotypes in hospitalized patients with all-cause infection using longitudinal body temperature measurements 6 . We hypothesize that using a similar approach specific to COVID-19 patients would identify subphenotypes with unique clinical characteristics and inflammatory and coagulation abnormalities. The primary outcome was 30-day inpatient mortality, which was modeled on subphenotype using Cox regression analysis, controlling for demographics, comorbidities, and severity of illness. The high mortality rate seen in Group 1 and the organ dysfunction seen in Group 4 suggest that both subphenotypes have a dysregulated response to COVID-19. In conclusion, we found four distinct subphenotypes of COVID-19 patients with markedly different clinical characteristics and mortality rates. abstract: nan url: https://api.elsevier.com/content/article/pii/S0012369220319565 doi: 10.1016/j.chest.2020.07.027 id: cord-001236-cgiok0ce author: Binjawadagi, Basavaraj title: An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination date: 2014-03-24 words: 7565.0 sentences: 389.0 pages: flesch: 47.0 cache: ./cache/cord-001236-cgiok0ce.txt txt: ./txt/cord-001236-cgiok0ce.txt summary: title: An innovative approach to induce cross-protective immunity against porcine reproductive and respiratory syndrome virus in the lungs of pigs through adjuvanted nanotechnology-based vaccination Therefore, we attempted to strengthen the immunogenicity of inactivated/killed PRRSV vaccine antigens (KAg), especially in the pig respiratory system, through: 1) entrapping the KAg in biodegradable poly(lactic-co-glycolic acid) nanoparticles (NP-KAg); 2) coupling the NP-KAg with a potent mucosal adjuvant, whole cell lysate of Mycobacterium tuberculosis (M. 32 In adjuvanted NP-KAgvaccinated pigs, increased avidity of virus-specific IgA was detected in both BAL fluid (both low and high doses) and lung homogenate (only low dose) samples compared to other tested groups (Figure 2A-C) . Adjuvanted poly(lactic-co-glycolic) acid nanoparticle-entrapped inactivated porcine reproductive and respiratory syndrome virus vaccine elicits cross-protective immune response in pigs Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs abstract: Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating respiratory disease of pigs. The disease is caused by the PRRS virus (PRRSV), an Arterivirus which is a highly mutating RNA virus. Widely used modified live PRRSV vaccines have failed to prevent PRRS outbreaks and reinfections; moreover, safety of the live virus vaccines is questionable. Though poorly immunogenic, inactivated PRRSV vaccine is safe. The PRRSV infects primarily the lung macrophages. Therefore, we attempted to strengthen the immunogenicity of inactivated/killed PRRSV vaccine antigens (KAg), especially in the pig respiratory system, through: 1) entrapping the KAg in biodegradable poly(lactic-co-glycolic acid) nanoparticles (NP-KAg); 2) coupling the NP-KAg with a potent mucosal adjuvant, whole cell lysate of Mycobacterium tuberculosis (M. tb WCL); and 3) delivering the vaccine formulation twice intranasally to growing pigs. We have previously shown that a single dose of NP-KAg partially cleared the challenged heterologous PRRSV. Recently, we reported that NP-KAg coupled with unentrapped M. tb WCL significantly cleared the viremia of challenged heterologous PRRSV. Since PRRSV is primarily a lung disease, our goal in this study was to investigate lung viral load and various immune correlates of protection at the lung mucosal surfaces and its parenchyma in vaccinated heterologous PRRSV-challenged pigs. Our results indicated that out of five different vaccine-adjuvant formulations, the combination of NP-KAg and unentrapped M. tb WCL significantly cleared detectable replicating infective PRRSV with a tenfold reduction in viral RNA load in the lungs, associated with substantially reduced gross and microscopic lung pathology. Immunologically, strong humoral (enhanced virus neutralization titers by high avidity antibodies) and cell-mediated immune responses (augmented population of interferon-γ secreting CD4(+) and CD8(+) lymphocytes and reduced secretion of immunosuppressive cytokines) in the lungs were observed. In conclusion, combination of NP-KAg and soluble M. tb WCL elicits broadly cross-protective anti-PRRSV immunity in the pig respiratory system. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969340/ doi: 10.2147/ijn.s59924 id: cord-273839-oasgagpc author: Bisno, Alan L. title: Diagnosis and Management of Group A Streptococcal Pharyngitis: A Practice Guideline date: 1997-09-17 words: 5771.0 sentences: 295.0 pages: flesch: 41.0 cache: ./cache/cord-273839-oasgagpc.txt txt: ./txt/cord-273839-oasgagpc.txt summary: Except under special circumstances, neither repeated bacteri-Evidence ologic testing (culture or RADT) of patients who have success-We reviewed a large number of clinical trials of diagnostic fully completed a course of antimicrobial therapy nor routine and treatment strategies for group A streptococcal pharyngitis. ple, studies of treatment were evaluated for randomization, A small percentage of patients will have recurrences of acute blinding, use of streptococcal typing to differentiate treatment pharyngitis that are associated with throat cultures (or RADTs) failures from new infections, duration and timing of follow-up positive for group A streptococci within a short period following examinations, and statistical power [1, 2] . Such tests are appropriate for streptococci in the upper respiratory tract and for the confirmation of the clinical diagnosis of acute streptococcal pharyngitis use by microbiology laboratory personnel, but most physicians who perform throat cultures would find it difficult to justify [12] (category A, grade II). abstract: This is the second in a series of practice guidelines commissioned by the Infectious Diseases Society of America through its Practice Guidelines Committee. The purpose of these guidelines is to provide assistance to clinicians when making decisions on treating the conditions specified in each guideline. The targeted providers are pediatricians, family practitioners, and internists. The targeted patients and setting for the acute pharyngitis guideline are pediatric, adolescent, and adult outpatients with a complaint of sore throat. Funding was provided by the IDSA. Panel members represented experts in adult and pediatric infectious diseases. The guidelines are evidence-based. A standard ranking system was used for the strength of the recommendations and the quality of the evidence cited in the literature reviewed. The document has been subjected to external review by peer reviewers as well as by the Practice Guidelines Committee and was approved by the IDSA Council. An executive summary, algorithms, and tables highlight the major recommendations. Indicators of quality will assist in guideline implementation. The guideline will be listed on the IDSA home page at http://www.idsociety.org. url: https://www.ncbi.nlm.nih.gov/pubmed/9314443/ doi: 10.1086/513768 id: cord-290465-tvegf0kt author: Brook, Judy title: Co-production of an intervention to increase retention of early career nurses: Acceptability and feasibility date: 2020-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Co-production is a process employed to solve complex issues, recognising the expertise of all stakeholders. This paper reports on co-production undertaken by nursing students, early career nurses and researchers as part of a larger study to design an intervention to increase retention of early career nurses. Mixed methods were used to evaluate the acceptability and feasibility of the co-production process in a UK university. Data were collected prospectively, concurrently and retrospectively via interview and questionnaire, between April 2018 and January 2019. Twelve co-production group members completed the questionnaire and six group members and facilitators were interviewed. Students and early career nurses reported personal benefit from participating; they developed and practised transferrable communication and problem-solving skills, believed they were able to make a difference, enjoyed contributing, found benefit from using the group as a reflective space and considered that co-production produced a credible intervention. Findings indicated co-production equipped participants to function more effectively in their nursing roles; incorporating co-production into the development of future interventions may prove beneficial. The relative novelty of this approach, and the potential application of the findings to a diverse range of geographical and organisational settings, add to the utility of the findings. url: https://doi.org/10.1016/j.nepr.2020.102861 doi: 10.1016/j.nepr.2020.102861 id: cord-295987-die9jmbv author: Chabre, Yoann M. title: Design and Creativity in Synthesis of Multivalent Neoglycoconjugates date: 2010-04-08 words: 51109.0 sentences: 2401.0 pages: flesch: 36.0 cache: ./cache/cord-295987-die9jmbv.txt txt: ./txt/cord-295987-die9jmbv.txt summary: PAP-a-Glc, poly(p-N-acryloylamidophenyl) a-glucopyranoside; PBS, phosphate buffered saline; PePO, pentaerythrityl phosphodiester oligomer; PET, photoinduced electron transfer; PITC, phenylisothiocyanate; PDT, photodynamic therapy; POSS, polyhedral oligosilsesquioxane; PMBC, peripheral blood mononuclear cells; PPI, polypropyleneimine; PS, photosensitizer; PVK, poly(methyl vinyl ketone); PyBOP, benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate; QSAR, quantitative structure-activity relationship; RCA 120 , Ricinus communis agglutinin; RGP, radial growth polymerization; SCVCP, self-condensing vinyl copolymerization; SEM, scanning electron microscopy; SHC, Sonogashira-Heck-Cassar cross coupling reactions; SLT, Shiga-like toxin; SLT-Iie, Shiga-like toxin II edema variant; SPG-Lac, schizophyllan bearing lactosides; SPR, surface plasmon resonance; SPS, solid-phase synthesis; STEC, Shiga toxigenic group of Escherichia coli; Stx, Shiga toxin; SWNT, single-walled nanotube; TBAF, tetra-n-butylammonium fluoride; TBAH, tetra-n-butylammonium hydroxide; TBTU, 2-(1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate; TEM, transmission electron microscopy; TEMPO, 2,2,6,6-tetramethylpiperidine-1-oxyl; TF, Thomsen-Friedenreich antigen; TFA, trifluoroacetic acid; TGA, thermogravimetric analysis; THF, tetrahydrofuran; TRIS, tris(hydroxymethyl)aminomethane; VAA, Viscum album agglutinin; VT, verotoxin; VV-HRP, horseradish peroxidase-labeled plant lectin V. abstract: From the authors' opinion, this chapter constitutes a modest extension of the seminal and inspiring contribution of Stowell and Lee on neoglycoconjugates published in this series [C. P. Stowell and Y. C. Lee, Adv. Carbohydr. Chem. Biochem., 37 (1980) 225–281]. The outstanding progresses achieved since then in the field of the “glycoside cluster effect” has witnessed considerable creativity in the design and synthetic strategies toward a vast array of novel carbohydrate structures and reflects the dynamic activity in the field even since the recent chapter by the Nicotra group in this series [F. Nicotra, L. Cipolla, F. Peri, B. La Ferla, and C. Radaelli, Adv. Carbohydr. Chem. Biochem., 61 (2007) 353–398]. Beyond the more classical neoglycoproteins and glycopolymers (not covered in this work) a wide range of unprecedented and often artistically beautiful multivalent and monodisperse nanostructures, termed glycodendrimers for the first time in 1993, has been created. This chapter briefly surveys the concept of multivalency involved in carbohydrate–protein interactions. The topic is also discussed in regard to recent steps undertaken in glycobiology toward identification of lead candidates using microarrays and modern analytical tools. A systematic description of glycocluster and glycodendrimer synthesis follows, starting from the simplest architectures and ending in the most complex ones. Presentation of multivalent glycostructures of intermediate size and comprising, calix[n]arene, porphyrin, cyclodextrin, peptide, and carbohydrate scaffolds, has also been intercalated to better appreciate the growing synthetic complexity involved. A subsection describing novel all-carbon-based glycoconjugates such as fullerenes and carbon nanotubes is inserted, followed by a promising strategy involving dendrons self-assembling around metal chelates. The chapter then ends with those glycodendrimers that have been prepared using commercially available dendrimers possessing varied functionalities, or systematically synthesized using either divergent or convergent strategies. url: https://www.ncbi.nlm.nih.gov/pubmed/20381707/ doi: 10.1016/s0065-2318(10)63006-5 id: cord-022643-2j559muh author: Chance, Gail D. title: SYSTEMATIC IMPLICATIONS OF SEED COAT MORPHOLOGY IN NAMA (HYDROPHYLLACEAE) date: 1984-07-01 words: 4604.0 sentences: 282.0 pages: flesch: 57.0 cache: ./cache/cord-022643-2j559muh.txt txt: ./txt/cord-022643-2j559muh.txt summary: Nevertheless, similarities among species in seed coat organization, particularly, outer testa anatomy and wall thickening‐pitting patterns allow the recognition of six groups among examined taxa; furthermore, seed coat features often suggest both intra‐group and inter‐group relationships. Hitchcock''s (1933) observation that seeds of different species exhibit variously patterned surfaces offers a promising point of departure for studies aimed at elucidating relationships in Nama. Seed Group 3 (Fig.11-19 )-Thesixincluded species are characterized by a reticulate seed coat in which pits-perforations (Fig. 11 , 15) are found in radial walls of the reticulum cells. Seed Group 4 (Fig. 20-35 )-Each ofthe nine species in this group produces a chambered coat ranging from weakly to deeply reticulate; and all possess localized thickenings in the radial walls of reticulum cells (Fig. 22, 23, 27-29, 32, 35) . In contrast to other species ofits group, unbranched thickenings often traverse the floor of reticulum cells (Fig. 35) and are reminiscent of those found in Seed Group 5. abstract: Seeds from 37 species of Nama (Hydrophyllaceae) were examined by scanning electron microscopy in order to assess systematic implications of seed coat structure. Generally, seed coat morphology is species specific. Nevertheless, similarities among species in seed coat organization, particularly, outer testa anatomy and wall thickening‐pitting patterns allow the recognition of six groups among examined taxa; furthermore, seed coat features often suggest both intra‐group and inter‐group relationships. Recognized groupings do not correspond well with the more classicial treatments of Nama; rather, they suggest that a restructuring of the infrageneric and even the generic taxonomy of Nama is in order. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159442/ doi: 10.1002/j.1537-2197.1984.tb14148.x id: cord-264607-5vnaifi6 author: Chen, Wenyu title: A study on clinical effect of Arbidol combined with adjuvant therapy on COVID‐19 date: 2020-06-08 words: 2520.0 sentences: 137.0 pages: flesch: 53.0 cache: ./cache/cord-264607-5vnaifi6.txt txt: ./txt/cord-264607-5vnaifi6.txt summary: OBJECTIVES: This study aims to explore the clinical effect of Arbidol (ARB) combined with adjuvant therapy on patients with coronavirus disease 2019 (COVID‐19). Various indexes in the two groups before and after treatment were observed and recorded, including fever, cough, hypodynamia, nasal obstruction, nasal discharge, diarrhea, C‐reactive protein (CRP), procalcitonin (PCT), blood routine indexes, blood biochemical indexes, time to achieve negative virus nucleic acid and so on. All clinical data of patients, including gender, hypertension, diabetes, CT, temperature, oxygen saturation, hemoglobin (HB) concentration, C-reactive protein (CRP) and so on, were listed in Table 1 Test group: ARB was additionally added on the basis of symptomatic treatment. Patient''s clinical symptoms, such as fever, dry cough, nasal obstruction, nasal discharge, sore throat, hypodynamia, diarrhea, and some laboratory indexes including blood routine indexes, CRP, procalcitonin (PCT), blood biochemical indexes as well as the virus nucleic acid testing were observed and recorded during the treatment. abstract: OBJECTIVES: This study aims to explore the clinical effect of Arbidol (ARB) combined with adjuvant therapy on patients with coronavirus disease 2019 (COVID‐19). METHODS: The study included 62 patients with COVID‐19 admitted to the First Hospital of Jiaxing from January to March, 2020, and all patients were divided into the test group and the control group according to whether they received ARB during hospitalization. Various indexes in the two groups before and after treatment were observed and recorded, including fever, cough, hypodynamia, nasal obstruction, nasal discharge, diarrhea, C‐reactive protein (CRP), procalcitonin (PCT), blood routine indexes, blood biochemical indexes, time to achieve negative virus nucleic acid and so on. RESULTS: The fever and cough in the test group were relieved markedly faster than those in the control group (p<0.05); there was no obvious difference between the two groups concerning the percentage of patients with abnormal CRP, PCT, blood routine indexes, aspartate aminotransferase and alanine aminotransferase (p>0.05); the time for two consecutive negative nucleic acid tests in the test group were shorter than that in the control group; the hospitalization period of the patients in the test group and control group were (16.5 ± 7.14) d and (18.55 ± 7.52) d, respectively. CONCLUSION: ARB combined with adjuvant therapy might be able to relieve the fever of COVID‐19 sufferers faster and accelerate the cure time to some degree, hence it's recommended for further research clinically. This article is protected by copyright. All rights reserved. url: https://www.ncbi.nlm.nih.gov/pubmed/32510169/ doi: 10.1002/jmv.26142 id: cord-256165-cc3ph5e5 author: Cree-Green, Melanie title: Peer mentoring for professional and personal growth in academic medicine date: 2020-07-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Mentorship is a critical component of career development, particularly in academic medicine. Peer mentorship, which does not adhere to traditional hierarchies, is perhaps more accessible for underrepresented groups, including women and minorities. In this article, we review various models of peer mentorship, highlighting their respective advantages and disadvantages. Structured peer mentorship groups exist in different settings, such as those created under the auspices of formal career development programs, part of training grant programs, or through professional societies. Social media has further enabled the establishment of informal peer mentorship through participatory online groups, blogs, and forums that provide platforms for peer-to-peer advice and support. Such groups can evolve rapidly to address changing conditions, as demonstrated by physician listserv and Facebook groups related to the COVID-19 pandemic. Peer mentorship can also be found among colleagues brought together through a common location, interest, or goal, and typically these relationships are informal and fluid. Finally, we highlight here our experience with intentional formation of a small peer mentoring group that provides structure and a safe space for professional and social–emotional growth and support. In order to maximize impact and functionality, this model of peer mentorship requires commitment among peers and a more formalized process than many other peer mentoring models, accounting for group dynamics and the unique needs of members. When done successfully, the depth of these mentoring relationships can produce myriad benefits for individuals with careers in academic medicine including, but not limited to, those from underrepresented backgrounds. url: https://doi.org/10.1136/jim-2020-001391 doi: 10.1136/jim-2020-001391 id: cord-270998-1adloi3o author: Cunha, Rafes D. S. title: Comparison of immunity against canine distemper, adenovirus and parvovirus after vaccination with two multivalent canine vaccines date: 2020-04-27 words: 2424.0 sentences: 125.0 pages: flesch: 50.0 cache: ./cache/cord-270998-1adloi3o.txt txt: ./txt/cord-270998-1adloi3o.txt summary: There is a belief among veterinary practitioners and even educational institutions that the vaccines made in Brazil against canine distemper virus (CDV), canine parvovirus (CPV) and canine adenovirus (CAV) are ineffective or only partially effective. METHODS: The study was carried out at the Animal Protection Association and a total of 60 adult mongrel dogs were selected and divided into two groups. RESULTS: In group A, the Elevencell vaccine generated a protective antibody titre against CDV in 26 out of 28 subjects (92.85%), CPV in 24 out of 28 subjects (85.71%) and CAV in 26 out of 28 subjects (92.85%). Before immunization, both groups of animals presented results of ≤2 on the colorimetric scale, which means that all of them were eligible to take part in the vaccination protocol. Evaluation of the humoral immune response induced by vaccination for canine distemper and parvovirus: A pilot study abstract: BACKGROUND: Viral diseases are a major cause of morbidity and mortality in puppies. There is a belief among veterinary practitioners and even educational institutions that the vaccines made in Brazil against canine distemper virus (CDV), canine parvovirus (CPV) and canine adenovirus (CAV) are ineffective or only partially effective. OBJECTIVES: This study aimed at comparing the immunity of two multivalent vaccines in adult dogs in the city of Uberlândia, Minas Gerais state, Brazil. METHODS: The study was carried out at the Animal Protection Association and a total of 60 adult mongrel dogs were selected and divided into two groups. Group A was immunized with two doses of Elevencell(®) vaccine and Group B received two doses of imported vaccine from the United States; each group was made up of 14 females and 14 males. RESULTS: In group A, the Elevencell vaccine generated a protective antibody titre against CDV in 26 out of 28 subjects (92.85%), CPV in 24 out of 28 subjects (85.71%) and CAV in 26 out of 28 subjects (92.85%). In group B, the imported US vaccine generated a protective antibody titre against CDV in 22 out of 28 subjects (78.57), CPV in 21 out of 28 subjects (75%) and CAV in 25 out of 28 subjects (89.28%). There was no statistical difference between titres generated between vaccine types for any of the three diseases tested. CONCLUSION: Elevencell vaccine titres were not inferior to the imported US vaccine in conferring protective titres against CDV, CPV and CAH, which confirms the efficacy of this product. url: https://doi.org/10.1002/vms3.274 doi: 10.1002/vms3.274 id: cord-271106-srym2kh4 author: De Rosa, Nicoletta title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study date: 2019-04-11 words: 3179.0 sentences: 162.0 pages: flesch: 44.0 cache: ./cache/cord-271106-srym2kh4.txt txt: ./txt/cord-271106-srym2kh4.txt summary: title: Effect of Immunomodulatory Supplements Based on Echinacea Angustifolia and Echinacea Purpurea on the Posttreatment Relapse Incidence of Genital Condylomatosis: A Prospective Randomized Study In conclusion, the presence of a latent infection causes condylomatosis relapse; in order to reduce the relapse risk an induction of a protective immune response seems to be essential to allow rapid viral clearance from genital areas surrounding lesion and treatment zones. EP and EA dry root extracts seem to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis. Therapy with HPVADL18 is effective in reducing relapse incidence of lesions in patients treated for genital condylomatosis. In conclusion, HPVADL185 seems to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis. abstract: Introduction. HPV infection is a highly infectious disease; about 65% of partners of individuals with genital warts will develop genital condylomatosis. Only in 20-30% it regresses spontaneously and relapse rates range deeply (9-80%). Echinacea extracts possess antiviral and immunomodulator activities. The aim of this study was to evaluate the efficacy of the therapy, using a formulation based on HPVADL18® (on dry extracts of 200 mg Echinacea Purpurea (EP) roots plus E. Angustifolia (EA)), on the posttreatment relapse incidence of genital condylomatosis. Materials and Methods. It is a prospective single-arm study. Patients with a satisfactory and positive vulvoscopy, colposcopy, or peniscopy for genital condylomatosis were divided into two random groups and subjected to destructive therapy with Co2 Laser. Group A (N=64) immediately after the laser therapy started a 4-month treatment with oral HPVADL18®; Group B (N=61) did not undergo any additional therapy. Patients were subjected to a follow-up after 1, 6, and 12 months. Differences in relapse incidence between the two groups during follow-up controls were evaluated by χ2-test; the groups were stratified by age, gender, and condylomatosis extension degree. Results and Discussion. Gender, age, and condyloma lesions' extension degree showed no statistically significant differences between the two trial groups. The relapse incidence differs statistically between the two studied groups and progressively decreases during the 12 months after treatment in both groups. Statistically significant reduction of relapse rates has been shown in Group A in patients over 25 years old. This difference is significant for both men and women. The relapse incidence is superior in case of extended condylomatosis. Conclusions. In conclusion, the presence of a latent infection causes condylomatosis relapse; in order to reduce the relapse risk an induction of a protective immune response seems to be essential to allow rapid viral clearance from genital areas surrounding lesion and treatment zones. Echinacea promotes this process. EP and EA dry root extracts seem to be a valid adjuvant therapy in reducing relapse incidence of lesions in patients treated for genital condylomatosis. url: https://www.ncbi.nlm.nih.gov/pubmed/31111049/ doi: 10.1155/2019/3548396 id: cord-013263-xw611i8k author: Dederichs, Melina title: Students’ perspectives on interventions to reduce stress in medical school: A qualitative study date: 2020-10-15 words: 5660.0 sentences: 351.0 pages: flesch: 51.0 cache: ./cache/cord-013263-xw611i8k.txt txt: ./txt/cord-013263-xw611i8k.txt summary: title: Students'' perspectives on interventions to reduce stress in medical school: A qualitative study 2. How do medical students perceive interventions that have been described in the literature (pass/fail grading, a peer-to-peer mentoring program, Balint groups, and self-management courses)? Possible solutions students brought up were for instance a mandatory lecture about stress related to medical school, coping strategies and support contacts. Participants proposed shortening clinical trainings, or to move them towards the end of the medical curriculum to avoid that students have to pass other exams right before the second state examination. In our eight focus groups, students suggested specific solutions to their perceived obstacles in medical school. Importantly, while setting-based interventions are sometimes considered expensive or difficult to implement [7] , most ideas in the focus groups (e.g. attendance rules, a new course selection procedure, teaching guidelines) seem easily feasible and resource-friendly and will not only improve wellbeing, but also academic performance. abstract: The mental health of medical students remains to be a matter of concern. Numerous setting-based and individual-based interventions for student mental health have been proposed in the literature. However, the student perspective on those interventions has been largely neglected. This study aims to explore how medical students perceive different interventions and if they desire any additional changes with regard to their studies. Eight focus groups with 71 participants were conducted at a large German medical school. Focus groups were recorded, transcribed and content-analyzed using MAXQDA 18. We found that medical students prefer setting-based interventions. Most proposed interventions were on a setting-based level. For instance, students asked for more information on the university’s psychosocial counseling services and for better information management regarding contact persons. Interventions proposed in the literature received mixed reactions: Several participants did not favour a pass/fail grading system. Students considered a peer-to-peer mentoring program for freshmen very helpful. Students had diverse attitudes towards Balint groups. They approved of several self-management courses, most of them being related to time or stress management. Interestingly, the most urgently wanted interventions appear to be rather easy to implement (e.g. a mentoring program). This study explored the medical student perspective on student mental health interventions. Additionally, our study illustrates the benefit and feasibility of involving students early on in the conception of interventions. Further research with a representative sample is needed to obtain broader information on the acceptance of the suggested interventions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7561099/ doi: 10.1371/journal.pone.0240587 id: cord-302079-pby3i6wq author: Deng, Yan title: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study date: 2020-06-05 words: 3332.0 sentences: 193.0 pages: flesch: 57.0 cache: ./cache/cord-302079-pby3i6wq.txt txt: ./txt/cord-302079-pby3i6wq.txt summary: title: Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and we compare them with recovered patients (recovered group). CONCLUSIONS: Compared to the recovered group, more patients in the death group exhibited characteristics of advanced age, pre-existing comorbidities, dyspnea, oxygen saturation decrease, increased WBC count, decreased lymphocytes, and elevated CRP levels. In our study, we found no significant difference between the death and recovered group in the percentage of patients complicated with diabetes. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study abstract: BACKGROUND: The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan, Hubei Province of China since December 2019. This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease (COVID-19). METHODS: Clinical data were collected from two tertiary hospitals in Wuhan. A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19 (death group) and we compare them with recovered patients (recovered group). Continuous variables were analyzed using the Mann-Whitney U test. Categorical variables were analyzed by χ(2) test or Fisher exact test as appropriate. RESULTS: Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients. The median age of the death group was older than the recovered group (69 [62, 74] vs. 40 [33, 57] years, Z = 9.738, P < 0.001). More patients in the death group had underlying diseases (72.5% vs. 41.4%, χ(2) = 22.105, P < 0.001). Patients in the death group had a significantly longer time of illness onset to hospitalization (10.0 [6.5, 12.0] vs. 7.0 [5.0, 10.0] days, Z = 3.216, P = 0.001). On admission, the proportions of patients with symptoms of dyspnea (70.6% vs. 19.0%, χ(2) = 60.905, P < 0.001) and expectoration (32.1% vs. 12.1%, χ(2) = 13.250, P < 0.001) were significantly higher in the death group. The blood oxygen saturation was significantly lower in the death group (85 [77, 91]% vs. 97 [95, 98]%, Z = 10.625, P < 0.001). The white blood cell (WBC) in death group was significantly higher on admission (7.23 [4.87, 11.17] vs. 4.52 [3.62, 5.88] ×10(9)/L, Z = 7.618, P < 0.001). Patients in the death group exhibited significantly lower lymphocyte count (0.63 [0.40, 0.79] vs. 1.00 [0.72, 1.27] ×10(9)/L, Z = 8.037, P < 0.001) and lymphocyte percentage (7.10 [4.45, 12.73]% vs. 23.50 [15.27, 31.25]%, Z = 10.315, P < 0.001) on admission, and the lymphocyte percentage continued to decrease during hospitalization (7.10 [4.45, 12.73]% vs. 2.91 [1.79, 6.13]%, Z = 5.242, P < 0.001). Alanine transaminase (22.00 [15.00, 34.00] vs. 18.70 [13.00, 30.38] U/L, Z = 2.592, P = 0.010), aspartate transaminase (34.00 [27.00, 47.00] vs. 22.00 [17.65, 31.75] U/L, Z = 7.308, P < 0.001), and creatinine levels (89.00 [72.00, 133.50] vs. 65.00 [54.60, 78.75] μmol/L, Z = 6.478, P < 0.001) were significantly higher in the death group than those in the recovered group. C-reactive protein (CRP) levels were also significantly higher in the death group on admission (109.25 [35.00, 170.28] vs. 3.22 [1.04, 21.80] mg/L, Z = 10.206, P < 0.001) and showed no significant improvement after treatment (109.25 [35.00, 170.28] vs. 81.60 [27.23, 179.08] mg/L, Z = 1.219, P = 0.233). The patients in the death group had more complications such as acute respiratory distress syndrome (ARDS) (89.9% vs. 8.6%, χ(2) = 148.105, P < 0.001), acute cardiac injury (59.6% vs. 0.9%, χ(2) = 93.222, P < 0.001), acute kidney injury (18.3% vs. 0%, χ(2) = 23.257, P < 0.001), shock (11.9% vs. 0%, χ(2) = 14.618, P < 0.001), and disseminated intravascular coagulation (DIC) (6.4% vs. 0%, χ(2) = 7.655, P = 0.006). CONCLUSIONS: Compared to the recovered group, more patients in the death group exhibited characteristics of advanced age, pre-existing comorbidities, dyspnea, oxygen saturation decrease, increased WBC count, decreased lymphocytes, and elevated CRP levels. More patients in the death group had complications such as ARDS, acute cardiac injury, acute kidney injury, shock, and DIC. url: https://www.ncbi.nlm.nih.gov/pubmed/32209890/ doi: 10.1097/cm9.0000000000000824 id: cord-270210-gfy2ytg5 author: Drent, Marjolein title: Benefit of Wearing an Activity Tracker in Sarcoidosis date: 2020-08-22 words: 4444.0 sentences: 243.0 pages: flesch: 51.0 cache: ./cache/cord-270210-gfy2ytg5.txt txt: ./txt/cord-270210-gfy2ytg5.txt summary: The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). The aim of this study was to estimate (1) the potential effect of continuous activity monitoring using an electronic AT, compared with a historical control group in a cohort study and (2) the effect of additional personal coaching of sarcoidosis patients in a randomized trial. Wearing an AT in general, even without personal coaching by a physical therapist, improved exercise capacity and reduced fatigue in sarcoidosis patients. abstract: Sarcoidosis causes many disabling symptoms, including fatigue and exercise limitations, which have been shown to improve by physical activity programs. The aim of this study was to estimate the effect of continuous activity monitoring using an electronic activity tracker (AT) on exercise performance and fatigue of sarcoidosis patients, compared to controls (cohort study), and the effect of additional personal coaching (randomized trial) over a period of 3 months. Fifty-four sarcoidosis patients received an AT (Group Ia: 27 with coaching and Group Ib: 27 without). A historical group of sarcoidosis patients (Group II; n = 41) who did not follow a physical activity program served as controls. Exercise performance of patients wearing an AT (Group I) improved compared with controls (Group II), including the 6MWD, % predicted (∆4.4 ± 9.1 versus ∆0.7 ± 5.0, respectively), and fatigue levels decreased (∆−3.9 ± 5.7 versus ∆−1.8 ± 5.3). Patients with coaching (Group Ia) showed greater improvement of exercise capacity over time than patients without coaching (Group Ib) as shown by the Steep Ramp Test results (watts: ∆20.2 ± 33.8 versus ∆5.7 ± 26.4; and SRT, VO(2)max, % predicted: ∆1.6 ± 2.6 versus ∆0.7 ± 2.3). Sarcoidosis patients wearing an AT achieved improvement of exercise performance and reduction of fatigue. We therefore recommend encouraging sarcoidosis patients to wear an AT to stimulate physical activity and reduce fatigue. The additional benefit of coaching needs to be explored in future studies. url: https://doi.org/10.3390/jpm10030097 doi: 10.3390/jpm10030097 id: cord-297138-t8b3914h author: Duijker, G. title: Reporting effectiveness of an extract of three traditional Cretan herbs on upper respiratory tract infection: Results from a double-blind randomized controlled trial date: 2015-04-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Ethnopharmacological relevance Observations from the island of Crete, Greece suggest that infusions of traditional Cretan aromatic plants, well known for their ethnopharmacological use in Eastern Mediterranean region and Near East, could be effective in the prevention and treatment of upper respiratory tract infections, including viral-induced infections. The aim of this study was to report the effectiveness of an essential-oil extract of three Cretan aromatic plants in the treatment of cases with an upper respiratory tract infection. Materials and methods A double blind randomized controlled trial was implemented between October 2013 and February 2014. An essential-oil extract of Cretan aromatic plants in olive oil (total volume of 15ml of essential oil per litre of olive oil) was administered as 0.5ml soft gel capsules, twice a day, for 7 days. Placebo treatment was 0.5ml olive oil in soft gel capsules. Eligible patients were those presenting for clinical examination in the selected setting with signs and symptoms of upper respiratory tract infection that had begun within the previous 24hours. Real-Time Polymerase Chain Reaction (PCR) was used for the detection of respiratory viruses. The primary outcome was the severity and duration of symptoms of upper respiratory tract infection, assessed using the Wisconsin Upper Respiratory System Survey (WURSS-21) questionnaire. A secondary outcome of interest was the change in C-reactive protein (CRP) status. Results One hundred and five patients completed the study: 51 in the placebo group, and 54 in the intervention (treated) group. Baseline characteristics were similar in the two groups. No statistically significant differences were found in symptom duration or severity between the two groups, although small and clinically favorable effects were observed. When the analysis was restricted to subjects with a laboratory-documented viral infection, the percentage of patients with cessation of symptoms after 6 days of treatment was 91% in the intervention group and 70% in the control group (p=0.089). At baseline, one third of the patients in each group had elevated CRP levels. At follow-up, the respective proportions were 0% in the intervention group and 15% in the placebo group (p=0.121). The data were also in a favorable direction when 50% and 80% symptom reduction points were considered for specific virus types. Conclusions Compared with placebo the essential-oil extract of three Cretan aromatic plants provided no detectable statistically significant benefit or harm in the patients with upper respiratory illness, although descriptive differences were identified in favorable direction mainly in the virus-positive population. url: https://doi.org/10.1016/j.jep.2015.01.030 doi: 10.1016/j.jep.2015.01.030 id: cord-261073-s0qpiovr author: Ehrengut, W. title: A two year serological surveillance of coronavirus infections in Hamburg date: 1980 words: 1356.0 sentences: 81.0 pages: flesch: 52.0 cache: ./cache/cord-261073-s0qpiovr.txt txt: ./txt/cord-261073-s0qpiovr.txt summary: The occurrence of OC-43 coronavirus-like infections in the population of Hamburg was determined by a monthly serological survey (hemagglutination inhibition test [HI]) undertaken between October 1974 and October 1976. Serological surveillance carried out at regular intervals on a large number of sera taken from representative groups reveals the total infection rates (apparent and non-apparent) and the level and distribution of the seroimmunity in the population. The following report of seroepidemiological studies of coronavirus infections is based upon observations made in the course of a surveillance programme in Hamburg (carried out since October 1974) in various sections of the population in which all age groups were represented. Serological study of coronavirus antibodies in Hamburg Occurrence of antibody against coronavirus (OC43) in the healthy population and in patients with a disease of the respiratory tract Seroepidemiologic survey of coronavirus (Strain OC 43) related infections in a children''s population abstract: The occurrence of OC-43 coronavirus-like infections in the population of Hamburg was determined by a monthly serological survey (hemagglutination inhibition test [HI]) undertaken between October 1974 and October 1976. Studies of 3,016 sera revealed a high incidence of HI antibodies (58.2%). The frequency of seropositive reactions (=1:8) and the geometric mean titer were higher in individuals 15 to 24 years old. Treatment of 50 positive sera (titer 1:16 – 1:64) with receptor destroying enzyme, kaolin and ethacridin for elimination of nonspecific inhibitors did not modify the HI-titer of the investigated sera. The serological seasonal pattern suggests that coronaviruses are circulating the whole year in the urban population with a prevalence in the fall-winter period. Of the 331 paired sera examined, 6.6% presented a four- to eightfold rise in titer within eight weeks. url: https://www.ncbi.nlm.nih.gov/pubmed/6248465/ doi: 10.1007/bf01639150 id: cord-012537-49v45di6 author: El-Ghandour, Mamdouh title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial date: 2020-08-28 words: 2825.0 sentences: 152.0 pages: flesch: 46.0 cache: ./cache/cord-012537-49v45di6.txt txt: ./txt/cord-012537-49v45di6.txt summary: title: Efficacy of Milrinone Plus Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension in Resource-Limited Settings: Results of a Randomized, Double-Blind Trial OBJECTIVES: The current study aimed to investigate the efficacy of oral sildenafil and intravenous milrinone infusion and compare the effects of these drugs in combination versus as monotherapy in neonates with PPHN. In newborn care units lacking this gold standard therapy for PPHN, treatment comprises pulmonary vasodilators such as oral sildenafil or continuous intravenous infusion of milrinone. In the current randomized controlled trial, sildenafil combined with milrinone was more effective at normalizing pulmonary artery pressure and improving survival rates than treatment with either of the two drugs as monotherapy. Results from the current study showed that the combination of oral sildenafil and intravenous milrinone resulted in improved clinical outcomes, reflected by reduced mortality and a significant decrease in PASP. abstract: BACKGROUND: The management of severe persistent pulmonary hypertension (PPHN) can be very challenging in many resource-limited centers without access to inhaled nitric oxide or extracorporeal membrane oxygenation. OBJECTIVES: The current study aimed to investigate the efficacy of oral sildenafil and intravenous milrinone infusion and compare the effects of these drugs in combination versus as monotherapy in neonates with PPHN. METHODS: A double-blind randomized controlled trial was conducted in which neonates with PPHN were divided into three groups of 20 patients each: group 1 received oral sildenafil starting at 0.5 mg/kg every 6 h to a target maintenance dose of 2 mg/kg every 6 h; group 2 received intravenous milrinone 0.5 μg/kg/min as a continuous infusion; and group 3 received both oral sildenafil and intravenous milrinone. RESULTS: Post-treatment pulmonary artery systolic pressure was significantly lower in group 3 than in groups 1 and 2, which both received monotherapy (p = 0.031). The oxygenation index also decreased significantly in the dual-therapy group (p = 0.002) compared with the monotherapy groups. Combined use of both drugs demonstrated a beneficial synergistic effect with better outcomes and reduced mortality. CONCLUSION: Dual therapy using sildenafil and milrinone was superior to monotherapy with either drug in neonates with severe PPHN and is recommended for use in resource-constrained settings. REGISTRATION: Pan African Clinical Trial Registry identifier number PACTR201902691230243. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453074/ doi: 10.1007/s40272-020-00412-4 id: cord-035024-kx9jfssi author: Elmelhat, Ahmed title: Comparison between Prophylactic versus Therapeutic Doses of Low-Molecular-Weight Heparin in Severely Ill Coronavirus Disease 2019 Patients in Relation to Disease Progression and Outcome date: 2020-10-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: The predominant coagulation abnormalities in patients with coronavirus disease 2019 (COVID-19) suggest a hypercoagulable state and are consistent with uncontrolled clinical observations of an increased risk of venous thromboembolism. AIM AND OBJECTIVES: To compare the effect of prophylactic versus therapeutic doses of enoxaparin in the treatment of severe cases of COVID-19 infection. MATERIALS AND METHODS: This was a retrospective observational study conducted at Latifa hospital, Dubai. Fifty-nine patients enrolled from March to June 2020 and divided into 2 groups: patients who received the prophylactic dose of enoxaparin (group 1) and patients who received the therapeutic dose of enoxaparin (group 2). RESULTS: The mean age of all cases was 47.2 ± 10.4 years, while the mean weight was 76.4 ± 13.4 kg. Males represented 79.7% of cases. Blood group “O” was the most frequent blood group (40.9%). None of the cases were smokers or using alcohol. Bronchial asthma, lung diseases, diabetes mellitus, hypertension, CKD, cardiac disease, thyroid disease, and immunodeficiency were present in 1.7, 1.7, 39, 27.1, 5.1, 1.7, 5.1, and 1.7% respectively. There was no significant difference between both study groups regarding personal and medical characteristics, except for hypertension where 35.9% of group 2 (therapeutic) cases were hypertensive compared to 10% of group 1 cases (prophylactic). There was a significant difference between both study groups regarding inflammatory markers improvement duration, duration of MV and O2 support duration, with longer duration among (therapeutic) group 2 cases compared to group 1 cases (prophylactic). There was a highly significant difference between both study groups regarding ICU admission, as 64% of group 1 cases were admitted compared to 25% of group 1 cases. Similarly, 38.5% of group 2 cases needed MV compared to only 10% of group 1 cases, which was statistically significant. There was no significant difference between both groups regarding bleeding tendency and mortality (p value 0.54). CONCLUSION: Our results showed that use of prophylactic dose of enoxaparin might have some benefits compared to the therapeutic dose in terms of less duration of ICU and hospital stay, duration of oxygen support, need and duration of MV, and normalization of inflammatory markers. However, there was no significant difference between the 2 regimens regarding the mortality. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7649681/ doi: 10.1159/000511163 id: cord-353256-7nfklun9 author: Eroglu‐Ertugrul, Nesibe Gevher title: The value of flexible bronchoscopy in pulmonary infections of immunosuppressed children date: 2019-11-22 words: 3097.0 sentences: 178.0 pages: flesch: 39.0 cache: ./cache/cord-353256-7nfklun9.txt txt: ./txt/cord-353256-7nfklun9.txt summary: OBJECTIVES: To demonstrate the value of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) when determining causes of lung infection in immunocompromised children; to investigate differences in causes and radiological features of lung infections following bone marrow transplantation (BMT) compared to other immunosuppressive conditions; to evaluate the reliability of radiological findings when predicting the pathogen. The purpose of the study was to demonstrate the value of FB and BAL in determining the cause of lung infections that develop in immunocompromised children, to investigate differences between the causes and radiological features of lung infections following BMT in comparison to other immunosuppressive conditions and to evaluate the reliability of radiological findings for predicting the causative pathogen. When all of the patients were considered together, a significant association was determined between the presence of viral pathogens (including CMV) and the radiological findings of interstitial infiltration and/or a ground-glass appearance (P = .003). abstract: OBJECTIVES: To demonstrate the value of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) when determining causes of lung infection in immunocompromised children; to investigate differences in causes and radiological features of lung infections following bone marrow transplantation (BMT) compared to other immunosuppressive conditions; to evaluate the reliability of radiological findings when predicting the pathogen. METHODS: We retrospectively evaluated 132 immunosuppressed children who underwent FB and BAL because pulmonary complications between January 1999 and May 2014 at the Hacettepe University Hospital Pediatric Pulmonology Unit. Two groups, Group I (n = 106) and Group II (n = 26), consisted of patients who had primary or secondary immunodeficiency and those who were immunosuppressed because BMT, respectively. Radiological findings before FB and macroscopic and microscopic findings of the procedure were evaluated. RESULTS: FB and BAL were diagnostic in 86/132 patients (65.1%) and the antimicrobial treatment changed for 75/132 patients (56.8%). The most common pathogen was bacteria (Streptococcus pneumoniae was the leading one). Bacteria were more frequent in Group I than Group II (P = .008). No significant difference in radiological findings between Groups I and II was found. Considering all patients, a significant association was detected between viral pathogens and radiologically interstitial infiltration and a ground‐glass appearance (P = .003). However, no significant association was detected between bacterial and fungal pathogens and the radiological findings. CONCLUSION: In immunosuppressed patients, FB and BAL should be evaluated early for clarifying the causative agents. Then, appropriate treatments can be utilised and the side effects and high cost of unnecessary treatment may be mitigated. url: https://www.ncbi.nlm.nih.gov/pubmed/31710418/ doi: 10.1111/crj.13103 id: cord-022879-j6cecioe author: Fager, Edward W. title: Determination and Analysis of Recurrent Groups date: 1957-10-01 words: 6287.0 sentences: 279.0 pages: flesch: 57.0 cache: ./cache/cord-022879-j6cecioe.txt txt: ./txt/cord-022879-j6cecioe.txt summary: Transformation of the data or the use of rank correlation could overcome this difficulty, but any method which involves a measure of abundance may, in certain cases, not lead to the desired results : two species may always occur together and never separately and yet, unless there is a nearly constant relation between the relative numbers of individuals of the two species, a correlation coefficient will indicate no relationship even though they are a constant part of each other''s biological environment. The following example shows that it is not a satisfactory criterion for grouping if the groups are to be composed of species which form a nearly constant part of each other''s biological environment: Species 1 and 2 show no evidence of association when examined by Cole''s method and yet they nearly always occur together-over 80% of the occurrences of each are in company with the other -and should be considered together in any grouping based on this set of samples. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163427/ doi: 10.2307/1943124 id: cord-274563-jimw6skv author: Fiumara, Agata title: COVID-19 Pandemic Outbreak and its Psychological Impact on Patients with Rare Lysosomal Diseases date: 2020-08-22 words: 3524.0 sentences: 163.0 pages: flesch: 50.0 cache: ./cache/cord-274563-jimw6skv.txt txt: ./txt/cord-274563-jimw6skv.txt summary: During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Based on the feeling that our patients were experiencing profound distress, we designed a structured interview [3, 4] with the aim to evaluate how, and to which extent, the COVID-19 pandemic was changing our patients'' behavior and feelings about their chronic disease, the impact on therapies, and their future expectations. abstract: Background: Lysosomal storage disorders (LSDs) are rare, chronic, progressive multisystem diseases implying severe medical issues and psychological burden. Some of these disorders are susceptible to a treatment, which is administered weekly or every other week, in a hospital. During the COVID-19 (Corona Virus Disease 2019) pandemic lockdown, patients with LSDs on enzyme replacement therapy (ERT) missed their scheduled access to the Day Hospital to get their treatment. Methods: Based on the feeling that our patients were experiencing profound distress, we designed a structured telephone interview with the aim to evaluate how, and to which extent, the pandemic outbreak was changing their behavior and feelings about their chronic disease, the impact on therapies, and future expectations. The same interview was administered to an age-matched control group. Results: All interviewed people experienced an increase of anxiety, worries, and uncertainty fostered by incessant media updates. Moreover, a striking similarity emerged between the groups regarding forced home reclusion and the profound feeling to be excluded by normal life, well-known to those affected by a chronic rare disease. Conclusions: Although no statistically significant difference was found compared to controls, we felt that the reactions were qualitatively different, underlining the fragility and isolation of such patients. url: https://doi.org/10.3390/jcm9092716 doi: 10.3390/jcm9092716 id: cord-010305-z5c7zgp7 author: GARDEN, JENNI G. title: Habitat structure is more important than vegetation composition for local‐level management of native terrestrial reptile and small mammal species living in urban remnants: A case study from Brisbane, Australia date: 2007-08-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract As urban areas continue to expand and replace natural and agricultural landscapes, the ability to manage and conserve native wildlife within urban environments is becoming increasingly important. To do so we first need to understand species' responses to local‐level habitat attributes in order to inform the decision‐making process and on‐ground conservation actions. Patterns in the occurrence of native terrestrial reptile and small mammal species in 59 sites located in remnant urban habitat fragments of Brisbane City were assessed against local‐level environmental characteristics of each site. Cluster analysis, multidimensional scaling ordination, and principal axis correlation were used to investigate relationships between species' occurrences and environmental characteristics. Native reptiles were most strongly associated with the presence of termite mounds, a high amount of fallen woody material, and a moderate amount of weed cover. Native small mammals were most strongly associated with the presence of grass trees (Xanthorrhoea spp.), and both reptiles and small mammals were negatively influenced by increased soil compaction. Significant floristic characteristics were considered to be important as structural, rather than compositional, habitat elements. Therefore, habitat structure, rather than vegetation composition, appears to be most important for determining native, terrestrial reptile and small mammal species assemblages in urban forest fragments. We discuss the management implications in relation to human disturbances and local‐level management of urban remnants. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175953/ doi: 10.1111/j.1442-9993.2007.01750.x id: cord-303807-fka9svzu author: Gerber, Michael A. title: Diagnosis and Treatment of Pharyngitis in Children date: 2005-05-28 words: 7181.0 sentences: 319.0 pages: flesch: 37.0 cache: ./cache/cord-303807-fka9svzu.txt txt: ./txt/cord-303807-fka9svzu.txt summary: Guidelines from the Infectious Diseases Society of America (IDSA) [10] , American Academy of Pediatrics [11] , and American Heart Association [12] indicate that microbiologic confirmation (with a throat culture or RADT) is required for the diagnosis of group A beta-hemolytic streptococcal pharyngitis. Culture of a specimen obtained by throat swab on a sheep blood agar plate is the standard laboratory procedure for the microbiologic confirmation of the clinical diagnosis of acute group A beta-hemolytic streptococcal pharyngitis [16] . Currently, two of the most important issues regarding the use of RADTs for the diagnosis of group A beta-hemolytic streptococcal pharyngitis are the relative sensitivities of the different tests and whether any RADTs are sensitive enough to mitigate against the need to perform throat cultures in patients with negative test results. In addition, without the repeat isolation of the infecting strain of GAS (ie, true bacteriologic treatment failure), it is particularly difficult to determine the clinical significance of persistent or recurrent signs or symptoms suggesting group A beta-hemolytic streptococcal pharyngitis. abstract: Acute pharyngitis is one of the most common illnesses for which children visit primary care physicians. Most cases of acute pharyngitis in children are caused by viruses and are benign and self-limited. Group A beta-hemolytic streptococcus is the most important of the bacterial causes of acute pharyngitis. Strategies for diagnosis and treatment of acute pharyngitis are directed at distinguishing children with viral pharyngitis, who would not benefit from antimicrobial therapy, from children with group A beta-hemolytic streptococcal pharyngitis, for whom antimicrobial therapy would be beneficial. Making this distinction is crucial in attempting to minimize the unnecessary use of antimicrobial agents in children. url: https://www.ncbi.nlm.nih.gov/pubmed/15925660/ doi: 10.1016/j.pcl.2005.02.004 id: cord-347960-vl5zhxyh author: Giallonardo, Vincenzo title: The Impact of Quarantine and Physical Distancing Following COVID-19 on Mental Health: Study Protocol of a Multicentric Italian Population Trial date: 2020-06-05 words: 6319.0 sentences: 282.0 pages: flesch: 43.0 cache: ./cache/cord-347960-vl5zhxyh.txt txt: ./txt/cord-347960-vl5zhxyh.txt summary: The present study has been developed with the aims to: a) evaluate the impact of COVID-19 pandemic and its containment measures on mental health of the Italian population; b) to identify the main areas to be targeted by supportive long-term interventions for the different categories of people exposed to the pandemic. The survey includes the following self-reported questionnaires: the General Health Questionnaire -12 items (GHQ-12) (31); the Depression, Anxiety and Stress Scale -21 Items (DASS-21) (32); the Obsessive-Compulsive Inventory -Revised (OCI-R) (33); the Insomnia Severity Index (34) ; the Severity-of-Acute-Stress-Symptoms-Adult (35); the Suicidal Ideation Attributes Scale (SIDAS) (36); the Impact of Event Scale -6 items (37); the UCLA loneliness scale -short version (38) ; the Brief COPE (39); the Post Traumatic Growth Inventory short form (40) ; the Connor-Davidson Resilience Scaleshort form (41) ; the Multidimensional Scale of Perceived social support (42); the Pattern of Care Schedule (PCS)-modified version (43); the Maslach Burnout Inventory (only for health professionals) (44) . abstract: The COVID-19 pandemic and its related containment measures—mainly physical distancing and isolation—are having detrimental consequences on the mental health of the general population worldwide. In particular, frustration, loneliness, and worries about the future are common reactions and represent well-known risk factors for several mental disorders, including anxiety, affective, and post-traumatic stress disorders. The vast majority of available studies have been conducted in China, where the pandemic started. Italy has been severely hit by the pandemic, and the socio-cultural context is completely different from Eastern countries. Therefore, there is the need for methodologically rigorous studies aiming to evaluate the impact of COVID-19 and quarantine measures on the mental health of the Italian population. In fact, our results will help us to develop appropriate interventions for managing the psychosocial consequences of pandemic. The “COVID-IT-mental health trial” is a no-profit, not-funded, national, multicentric, cross-sectional population-based trial which has the following aims: a) to evaluate the impact of COVID-19 pandemic and its containment measures on mental health of the Italian population; b) to identify the main areas to be targeted by supportive long-term interventions for the different categories of people exposed to the pandemic. Data will be collected through a web-platform using validated assessment tools. Participants will be subdivided into four groups: a) Group 1—COVID-19 quarantine group. This group includes the general population which are quarantined but not isolated, i.e., those not directly exposed to contagion nor in contact with COVID-19+ individuals; b) Group 2—COVID-19+ group, which includes isolated people directly/indirectly exposed to the virus; c) Group 3—COVID-19 healthcare staff group, which includes first- and second-line healthcare professionals; d) Group 4—COVID-19 mental health, which includes users of mental health services and all those who had already been diagnosed with a mental disorder. Mental health services worldwide are not prepared yet to manage the short- and long-term consequences of the pandemic. It is necessary to have a clear picture of the impact that this new stressor will have on mental health and well-being in order to develop and disseminate appropriate interventions for the general population and for the other at-risk groups. url: https://doi.org/10.3389/fpsyt.2020.00533 doi: 10.3389/fpsyt.2020.00533 id: cord-026983-36n7bm3j author: Gillani, Syeda Shaista title: Synthesis, characterization and applications of poly-aliphatic amine dendrimers and dendrons date: 2020-06-17 words: 6437.0 sentences: 393.0 pages: flesch: 51.0 cache: ./cache/cord-026983-36n7bm3j.txt txt: ./txt/cord-026983-36n7bm3j.txt summary: Figure 1 shows the well-defined structure of a dendrimer composed of various components: a) Multiple reactive sites originate from the central core which further grows into branches layer-by-layer in a symmetric fashion to form dendrimer generations. In PPI and PAMAM dendrimers, the number of pincers is half the amount of terminal surface groups as in these dendrimers, the chain disconnects into two chains in each focal point. Literature reveal the synthesis of a number of aliphatic polyamide amine dendrimers shown in PAMAM dendrons based silica-coated magnetic nanoparticles have been synthesized (Fig. 9 ). The structures and tunable surface functionalities of dendrimers allow for the encapsulation/complexation/conjugation of multiple entities, i.e. the drug molecules, and genetic materials, targeting agents and dyes, either in the core or on the surface, rendering them ideal carriers for various drugs. There are many examples where dendritic species including PAMAM dendrimers have been incorporated into scaffolds for the regeneration of a variety of tissues and cell types [127] . abstract: In the current era, the dendrimers have vast potential applications in the area of electronics, healthcare, pharmaceuticals, biotechnology, engineering products, photonics, drug delivery, catalysis, electronic devices, nanotechnologies and environmental issues. This review recaps the synthesis, characterization and applications of poly-aliphatic amine dendrimers. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298932/ doi: 10.1007/s13738-020-01973-4 id: cord-300046-orlga9qf author: Gomes da Silva, J. title: Health literacy of inland population in the mitigation phase 3.2. of COVID-19''s pandemic in Portugal - a descriptive cohort study date: 2020-05-14 words: 5399.0 sentences: 273.0 pages: flesch: 48.0 cache: ./cache/cord-300046-orlga9qf.txt txt: ./txt/cord-300046-orlga9qf.txt summary: Globally, younger individuals, females, graduates and the Non-Risk Group presented higher relative frequencies of the correct answer along COVID-19''s Questionnaire. However, three exceptions were observed: the Undergraduate Group and the Risk-Group had a high relative frequency stating that COVID-19 has a cure and in mentioning "Social Isolation" as an important preventive measure to adopt when compared to the Graduate Group and the Non-Risk Group, respectively. Males have higher relative frequency in answering the correct number of SNS24 and in stating that children can get sick and transmit the infection by SARS-CoV-2 when compared to females ( Table 2 -Supplementary information). Nonparametric tests reveal a statistically significant association regarding variable "Age", "Gender" and "Risk Factor", with younger individuals, females and individuals from Risk-Group stating more often the correct answer. Nonparametric tests reveal a statistically significant association regarding variable "Gender" and "Risk Factor", with males and individuals from Non-Risk Group answering the correct number. abstract: Background: COVID-19 is a respiratory disease transmitted through respiratory droplets with a high transmission rate. There's still no effective and approved antiretroviral treatment or vaccine, thus, preventive measures are the main key to contain this pandemic. Portugal is now in phase 3.2 of the mitigation of COVID-19, being imperative to understand the health literacy of our country and how to prevent the lack of information, through community empowerment. Material and methods: A cross-sectional study with a cohort from a primary care facility was conducted. We collected demographic and epidemiological data and carried out a questionnaire by phone call. Descriptive statistics and nonparametric tests were used to assess associations between the independent variables and the level of health literacy. The level of significance was set at p<0.05. Results: Our cohort includes 222 subjects (median age: 62 years old), mostly females (131), undergraduate (193) and with at least one risk factor for COVID-19 (144). Globally, younger individuals, females, graduates and the Non-Risk Group appear to have higher levels of health literacy, with some exceptions to this pattern. Conclusions: We observe a well-informed population. However, being a pandemic situation, we intend to identify and correct outliers/misconceptions. This work allows a perspective of the current state/pattern of health literacy as well as its possible predictors. Furthermore, this study makes aware of how relevant the specific communication approaches are. Further studies to understand the predictors of health literacy are necessary. Key-Words: COVID-19, pandemic, SARS-CoV2, Portugal, Health literacy. url: https://doi.org/10.1101/2020.05.11.20098061 doi: 10.1101/2020.05.11.20098061 id: cord-032657-1egdwe26 author: Gouda, Walaa title: COVID-19 disease: CT Pneumonia Analysis prototype by using artificial intelligence, predicting the disease severity date: 2020-09-25 words: 4128.0 sentences: 205.0 pages: flesch: 50.0 cache: ./cache/cord-032657-1egdwe26.txt txt: ./txt/cord-032657-1egdwe26.txt summary: Groups B and C showed significantly increased number of involved lung segments and lobes, frequencies of consolidation, crazy-paving pattern, and air bronchogram. CT severity score was estimated for each one of the five lung lobes by calculating the dissemination of the chest manifestations (opacity), namely the ground-glass opacities (GGO), consolidation, crazy-paving pattern, septal thickening, and pulmonary fibrosis giving score (0-4) for 0, 25, 50, and ≥ 75% involvement, respectively, with the sum representing the total severity scores for the whole lung (0-20). In our study, qualitative chest findings such as consolidation, air bronchogram, septal thickening, lung fibrosis, and pleural effusion showed a significant difference between group A and other groups (B and C) with P value < 0.001, but it could not differentiate between groups B and C. abstract: BACKGROUND: Since the beginning of 2020, coronavirus disease has spread widely all over the world and this required rapid adequate management; therefore, continuous searching for rapid and sensitive CT chest techniques was needed to give a hand for the clinician. We aimed to assess the validity of computed tomography (CT) quantitative and qualitative analysis in COVID-19 pneumonia and how it can predict the disease severity on admission. RESULTS: One hundred and twenty patients were enrolled in our study, 98 (81.7%) of them were males, and 22 (18.3%) of them were females with a mean age of 52.63 ± 12.79 years old, ranging from 28 to 83 years. Groups B and C showed significantly increased number of involved lung segments and lobes, frequencies of consolidation, crazy-paving pattern, and air bronchogram. The total lung severity score and the total score for crazy-paving and consolidation are used as severity indicators in the qualitative method and could differentiate between groups B and C and group A (90.9% sensitivity, 87.5% specificity, and 93.2% sensitivity, 87.5% specificity, respectively), while the quantitative indicators could differentiate these three groups. Using the quantitative CT indicators, the validity to differentiate different groups showed 84.1% sensitivity and 81.2% specificity for the opacity score, and 90.9% sensitivity and 81.2% specificity for the percentage of high opacity. CONCLUSION: Advances in CT COVID-19 pneumonia assessment provide an accurate and rapid tool for severity assessment, helping for decision-making notably for the critical cases. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7516225/ doi: 10.1186/s43055-020-00309-9 id: cord-275162-2239dk45 author: Gulla, Krishna Mohan title: Course of Illness after Viral Infection in Indian Children with Cystic Fibrosis date: 2018-06-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVE: To study the clinical impact of respiratory viral infection in children with cystic fibrosis (CF). DESIGN: Retrospective cohort study. SETTING: Tertiary care referral centre for CF in India. PARTICIPANTS/PATIENTS: Children with CF attending a pediatric chest clinic. METHODS: Case records of the children with CF who had a pulmonary exacerbation with documented acute respiratory viral infection between October 2013 and December 2014 (Group I) and an equal number of controls (Group II) with pulmonary exacerbation in absence of acute respiratory viral infection were reviewed. OUTCOME MEASURES: The two groups were compared for the following outcomes over a period of 12–18 months: bacterial colonization, antibiotics usage, pulmonary exacerbations, numbers of outpatient visits, hospitalization and oxygen therapy and spirometric parameters. RESULTS: In total, 46 children [23 each with viral infection (Group I) and without viral infection (Group II)] of age 7–264 months were enrolled; baseline clinical status and pulmonary function tests were comparable. Mean (SD) follow-up duration in those who had viral infection and who had no viral infection was 15.7 (7.1) and 17.5 (5.4) months, respectively. On follow-up, children with viral infection (Group I) had adverse outcome in form of greater worsening of Shwachman clinical scores, number of pulmonary exacerbations requiring antibiotic usage [4 (2.1%)] and [2.8 (1.7%)], need for intravenous antibiotics 30.4% vs. 8.7%, hospitalization rates 31.8% vs. 4.3% and mortality 30.4% vs. 4.7%, respectively. CONCLUSION: Acute viral infection in children with CF affected course of illness on follow-up, including frequent and severe pulmonary exacerbations requiring hospitalization, intravenous antibiotics, decline in CF scores and increased mortality over next 12–18 months. url: https://doi.org/10.1093/tropej/fmy033 doi: 10.1093/tropej/fmy033 id: cord-281309-c9y7m5do author: Guo, Baoqing title: Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus date: 2013-01-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The pathogenesis of Type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in 10-week old swine in the United States was investigated. rJXwn06, rescued from an infectious clone of Chinese HP-PRRSV, replicated in swine with at least 100-fold increased kinetics over U.S. strain VR-2332. rJXwn06 caused significant weight loss, exacerbated disease due to bacterial sepsis and more severe histopathological lung lesions in pigs exposed to HP-PRRSV than to those infected with VR-2332. Novel findings include identification of bacterial species present, the degree of thymic atrophy seen, and the inclusion of contact animals that highlighted the ability of HP-PRRSV to rapidly transmit between animals. Furthermore, comprehensive detailed cytokine analysis of serum, bronchoalveolar lavage fluid, and tracheobronchial lymph node tissue homogenate revealed a striking elevation in levels of cytokines associated with both innate and adaptive immunity in HP-PRRSV infected swine, and showed that contact swine differed in the degree of cytokine response. url: https://www.sciencedirect.com/science/article/pii/S0042682212004540 doi: 10.1016/j.virol.2012.09.013 id: cord-296606-aizjzglo author: Guo, Tingting title: Fangcang Shelter Hospital in Wuhan: A radiographic report on a cohort of 98 COVID-19 patients date: 2020-07-30 words: 3893.0 sentences: 220.0 pages: flesch: 60.0 cache: ./cache/cord-296606-aizjzglo.txt txt: ./txt/cord-296606-aizjzglo.txt summary: Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course. Conclusion: Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2(nd) week, followed by persistence of high levels and a prolonged median disease course. Therefore, the similar peak time, despite the higher initial CT score, when compared to the previous reports might have revealed the progressive nature of the disease at the absence of complicated treatments in the fangcang shelter hospitals, which was also evidenced by the slow decrease and persistent high CT scores after the 2 nd week in our study that was suggestive of the slow absorption of the COVID-19 lung lesions. abstract: Objectives: To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter hospital and to facilitate the understanding of the disease course. Materials and Methods: This retrospective study included 98 patients (males: females, 43:55, mean year, 49±12 years) with confirmed COVID-19 at Jianghan fangcang shelter hospital admitted between Feb 05, 2020, and Feb 09, 2020, who had initial chest CTs at our hospital. Radiographic features and CT scores were analyzed. Results: A total of 267 CT scans of 98 patients were evaluated. Our study showed a high median total CT score of 7 within the first week from symptom onset, peaked in the 2(nd) week at 10, followed by persistently high levels of CT score with 9.5, 7 and 7 for the week 3, 4, and >4, respectively, and a prolonged median disease course (30 days, the median interval between the onset of initial symptoms and discharge). Ground-glass opacity (GGO) (58%, 41/71) was the earliest and most frequent finding in week 1. Consolidation (26%, 14/53) and mixed pattern (40%, 21/53) were predominant patterns in 2(nd) week. GGO and reticular were the main patterns of later phase CT scans in patients with relatively advanced diseases who had longer illness duration (≥4 weeks). Among the 94 CT abnormalities obtained within 3 days from the twice RT-PCR test turned negative, the mixed pattern was mainly presented in patients with disease duration of 2-3 weeks, for GGO and reticular were common during the whole course. Conclusion: Discharged patients from fangcang shelter hospital demonstrated a high extent of lung abnormalities on CT within the first week from symptom onset, peaked at 2(nd) week, followed by persistence of high levels and a prolonged median disease course. GGO was the predominant pattern in week 1, consolidation and mixed pattern in 2(nd) week, whereas GGO and reticular patterns in later stages (≥4 weeks). url: https://www.ncbi.nlm.nih.gov/pubmed/32922173/ doi: 10.7150/ijms.48074 id: cord-280064-rz8cglyt author: Gwizdałła, Tomasz title: Viral disease spreading in grouped population date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background and Objective The currently active COVID-19 pandemic has increased, among others, public interest in the computational techniques enabling the study of disease-spreading processes. Thus far, numerous approaches have been used to study the development of epidemics, with special attention paid to the identification of crucial elements that can strengthen or weaken the dynamics of the process. The main thread of this research is associated with the use of the ordinary differential equations method. There also exist several approaches based on the analysis of flows in the Cellular Automata (CA) approach. Methods In this paper, we propose a new approach to disease-spread modeling. We start by creating a network that reproduces contacts between individuals in a community. This assumption makes the presented model significantly different from the ones currently dominant in the field. It also changes the approach to the act of infection. Usually, some parameters that describe the rate of new infections by taking into account those infected in the previous time slot are considered. With our model, we can individualize this process, considering each contact individually. Results The typical output from calculations of a similar type are epidemic curves. In our model, except of presenting the average curves, we show the deviations or ranges for particular results obtained in different simulation runs, which usually lead to significantly different results. This observation is the effect of the probabilistic character of the infection process, which can impact, in different runs, individuals with different significance to the community. We can also easily present the effects of different types of intervention. The effects are studied for different methods used to create the graph representing a community, which can correspond to different social bonds. Conclusions We see the potential usefulness of the proposition in the detailed study of epidemic development for specific environments and communities. The ease of entering new parameters enables the analysis of several specific scenarios for different contagious diseases. url: https://www.sciencedirect.com/science/article/pii/S0169260720315480?v=s5 doi: 10.1016/j.cmpb.2020.105715 id: cord-278032-27ikx97x author: GÖKER, Hakan title: The effects of blood group types on the risk of COVID-19 infection and its clinical outcome date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND/AIM: COVID-19 (Coronavirus disease of 2019) is an infectious disease outbreak later on declared as a pandemic, caused by the SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). It spreads very rapidly and can result in severe acute respiratory failure. The clinical studies have shown that advanced age and chronic diseases increase the risk of infection. However, influence of the blood groups on COVID-19 infection and its outcome remains to be confirmed. The aim of this study is to investigate whether there exists a relationship between the blood groups of the patients and risk of SARS-CoV-2 infection and the clinical outcomes in COVID-19 patients. MATERIAL AND METHOD: 186 patients with PCR confirmed diagnosis of COVID-19 were included in this study. Age, sex, blood groups, comorbidities, need for intubation and intensive care unit follow up and mortalities of the patients were analyzed retrospectively. 1881 healthy individuals, who presented to the Hacettepe University Blood Bank served as the controls. RESULTS: The most frequently detected blood group was blood group A (57%) amongst the COVID-19 patients. This was followed by blood group O (24.8%). The blood group types did not affect the clinical outcomes. The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). On the other hand, the frequency of blood group O was significantly lower in the COVID-19 patients, compared to the control group (24.8% vs. 37.2%, P: 0.001; OR: 1.8). CONCLUSIONS: The results of the present study suggest that while the blood group A might have a role in increased susceptibility to the COVID-19 infection, the blood group O might be somewhat protective. However, once infected, blood group type does not seem to influence clinical outcome. url: https://doi.org/10.3906/sag-2005-395 doi: 10.3906/sag-2005-395 id: cord-298569-174bzxdh author: Gånheim, Charina title: Acute phase proteins as indicators of calf herd health date: 2006-03-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The potential for using acute phase proteins (APPs) in the assessment of herd health was studied by examining the levels of serum haptoglobin, serum amyloid A (SAA) and plasma fibrinogen in relation to clinical findings and leukocyte counts in calves. Two groups of calves from conventional dairy farms were studied. The animals were examined 10 times during the first six weeks after introduction into a new environment. Haptoglobin, SAA and fibrinogen were analysed and weight gain, disease symptoms and treatments were recorded. Analysis of antibodies against viral infections was performed. An acute phase reaction (APR) score was established at each sampling by combining the APP results and total leukocyte counts. The health status differed between the two groups, although no manipulation of health had been performed, except that the group with a higher incidence of disease had a concurrent experimental infection with lungworm as part of another study. In the group with a higher incidence of disease, the mean weight gain was significantly lower, and the number of sampling days with elevated serum concentrations of APPs, and the mean maximum concentrations of haptoglobin and fibrinogen were significantly higher compared to the healthier group. The APR score was significantly higher at days 4 and 8 of the study in the group with a higher incidence of disease. The results indicate that measurement of APPs could be a useful tool for evaluation of health in calf herds. url: https://api.elsevier.com/content/article/pii/S1090023306000220 doi: 10.1016/j.tvjl.2006.01.011 id: cord-260272-645g3to1 author: Haddad, Kevin title: COVID-19 implications on STEMI care date: 2020-09-19 words: 2058.0 sentences: 113.0 pages: flesch: 56.0 cache: ./cache/cord-260272-645g3to1.txt txt: ./txt/cord-260272-645g3to1.txt summary: In the context of a global lockdown, both new organizational barriers and patients'' fear of acquiring COVID-19 have led to major concerns of undue delays in seeking appropriate emergent care, in particular for ST-elevation myocardial infarction (STEMI) patients. A total of 167 patients with STEMI were included in our analysis (72 from the Cité-de-la-Santé Killip class at time of hospital presentation was more advanced for patients with a STEMI during the lockdown period compared to the pre-COVID era, with significantly more cases categorized as a Killip class >1 (Group A 18.3% vs. J o u r n a l P r e -p r o o f Journal Pre-proof MACE rates after the index procedure for patients admitted during the lockdown period were significantly higher than those observed in 2019 during the same period or the one recorded between January and mid-March 2020 (22.6% vs. Indeed, our study highlights that, during the lockdown period, delays in seeking care were associated with more advanced heart failure on presentation and significantly higher rates of inhospital MACE. abstract: Background Coronavirus disease 2019 (COVID-19) has forced dramatic changes to the healthcare systems throughout the world. Time-sensitive management of cardiovascular emergencies such as ST-elevation myocardial infarction (STEMI) has yet to be evaluated in the context of these new policies, particularly in so-called “hot spot” cities. Methods We evaluated the early impact of the pandemic on STEMI performance in the Greater Montreal Area. A total of 167 patients from 3 different study periods were included. Patients presenting in the lockdown period from mid-March to mid-May 2020 (Group C, 53 patients) were compared to those from mid-March to mid-May 2019 (Group A, 60 patients) and the 2020 pre-COVID-19 period (Group B, 54 patients). Results The number of STEMI admissions was unaffected during the lockdown. However, significantly longer delays between symptom onset and first medical contact (FMC) were noted (Group C 189.0 IQR [70.0, 840.0] min vs. Group A 103.0 IQR [42.5, 263.0] min vs. Group B 91.0 IQR [38.0, 235.5 min], P= 0.007). In contrast, additional safety protocols do not appear to have significantly affected delays between FMC and first intracoronary device activation (Group C 102 IQR [73.0, 133.0] min vs. Group A 104 IQR [87.0, 146.0] min vs. Group B 99.5 IQR [80.0, 150.0] min, P=0.37). Patients that presented during the outbreak were more likely to be unstable with a higher incidence of Killip classes II-IV compared to groups A and B (28.3% vs. 18.3% vs. 5.6% respectively, P=0.008). Worse in-hospital outcomes were also noted with a significantly higher rate of major adverse cardiac events (Group A 5.0% vs. Group B 11.1% vs. Group C 22.6%, P=0.007). Conclusion During the lockdown period, many patients appear to have been reluctant to present to hospitals. This was associated with more unstable STEMI presentations and worse in-hospital course. Importantly, the health care system appears able to ensure timely acute cardiac care while ensuring that COVID-19 protocols are respected. url: https://www.sciencedirect.com/science/article/pii/S155383892030573X?v=s5 doi: 10.1016/j.carrev.2020.09.024 id: cord-299881-weptfpa2 author: Halvachizadeh, Sascha title: The impact of SARS-CoV-2 (COVID-19) pandemic on trauma bay management and guideline adherence in a European level-one-trauma centre date: 2020-07-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: SARS CoV-2 (COVID-19) represents a pandemic that has led to adjustments of routine clinical practices. The initial management in the trauma bay follows detailed international valid algorithms. This study aims to work out potential adjustments of trauma bay algorithms during a global pandemic in order to reduce contamination and to increase safety for patients and medical personnel. METHODS: This retrospective cohort study compared patients admitted to the trauma bay of one academic level-one trauma centre in March and April 2019 with patients admitted in March and April 2020. Based on these datasets, possible adjustments of the current international guidelines of trauma bay management were discussed. RESULTS: Group Pan (2020, n = 30) included two-thirds the number of patients compared with Group Ref (2019, n = 44). The number of severely injured patients comparable amongst these groups: mean injury severity score (ISS) was significantly lower in Group Pan (10.5 ± 4.4 points) compared with Group Ref (15.3 ± 9.2 points, p = 0.035). Duration from admission to whole-body CT was significantly higher in Group Pan (23.8 ± 9.4 min) compared with Group Ref (17.3 ± 10.7 min, p = 0.046). Number of trauma bay admissions decreased, as did the injury severity for patients admitted in March and April 2020. In order to contain spreading of SARS Cov-2, the suggested recommendations of adjusting trauma bay protocols for severely injured patients include (1) minimizing trauma bay team members with direct contact to the patient; (2) reducing repeated examination as much as possible, with rationalized use of protective equipment; and (3) preventing potential secondary inflammatory insults. CONCLUSION: Appropriate adjustments of trauma bay protocols during pandemics should improve safety for both patients and medical personnel while guaranteeing the optimal treatment quality. The above-mentioned proposals have the potential to improve safety during trauma bay management in a time of a global pandemic. url: https://doi.org/10.1007/s00264-020-04740-5 doi: 10.1007/s00264-020-04740-5 id: cord-024698-jrnw1i07 author: Hogan, Kevin title: Decidio: A Pilot Implementation and User Study of a Novel Decision-Support System date: 2020-04-25 words: 4017.0 sentences: 266.0 pages: flesch: 58.0 cache: ./cache/cord-024698-jrnw1i07.txt txt: ./txt/cord-024698-jrnw1i07.txt summary: 3 we present the use case for the user study of Decidio and demonstrate how our tool was incorporated into an existing group decision-making process. Students logged into Decidio via their personal laptops and navigated to the group project ranking dashboard. Learn their process, methods, and strategies employed for decision-making when ranking projects as a group 3. An activity log file created for every user that captured their actions as a workflow diagram was used to understand how student groups used Decidio in their decision making process. Finally, it is difficult to generalize results about user behavior in the tool when each team consists of a different mix of personalities and individual ranking preferences. In this paper, we present Decidio, a software tool that supports collaborative decision making. The activity logs showed us the various workflows used by student groups for decision-making. abstract: In this work, we add to the rich history of decision-support system research by implementing and evaluating a pilot implementation of a novel system, which we call Decidio. Our tool was integrated into a pre-existing decision-making process regularly conducted by 9 teams of undergraduate students. We find an overall positive response to Decidio based on the results of a tool evaluation survey that we conducted after our experiment. Furthermore, we conduct a Big-Five Factor personality survey of participants and associate personalities with interactions recorded by our tool. We find that the students who demonstrate leadership behaviors through their interactions score higher in extraversion and lower in conscientiousness than other students. Our analysis also reveals that agreeableness is strongly correlated with dissimilarity between group ranking outcomes and initially indicated individual preferences. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215188/ doi: 10.1007/978-3-030-48641-9_14 id: cord-032410-g546hez9 author: Hu, Yuan title: Behavioral and Biochemical Effects of KXS on Postmyocardial Infarction Depression date: 2020-08-27 words: 4639.0 sentences: 234.0 pages: flesch: 48.0 cache: ./cache/cord-032410-g546hez9.txt txt: ./txt/cord-032410-g546hez9.txt summary: In the present study, we aimed to explore whether KXS had both antidepressive effects and cardioprotective functions in a rat model of myocardial ischemia (MI) with depression. RESULTS: After 7 weeks of experiment, depression-like behaviors were observed in all the groups except for control and KXS groups, and KXS treatment dramatically increased open-field test scores and sucrose consumption (P < 0.01 vs. However, after 28 days, the sucrose consumption and open-field test scores were significantly reduced in the depression and model groups (data not shown), and such results were consistent with previous study . In the present study, we found that KXS had antidepressive effect and cardioprotective function by a rat model of MI with depression. After KXS treatment, open-field test scores, and sucrose consumption, which are indicators for evaluating depression-like behaviors, were significantly increased compared with the model group. abstract: BACKGROUND: Depression and coronary heart disease (CHD) often occur together in clinical practice. As a traditional Chinese medicine, Kai-Xin-San (KXS) has been widely used for the treatment of emotion-related disorders. In the present study, we aimed to explore whether KXS had both antidepressive effects and cardioprotective functions in a rat model of myocardial ischemia (MI) with depression. METHODS: A total of 50 SD rats were randomly assigned into five groups as follows: normal control (control group), celiac injection of isopropyl adrenaline (ISO) (MI group), depression (depression group), MI+ depression (model group) and MI+ depression treated with intragastric administration of 370 mg/kg KXS (KXS group). MI was induced by subcutaneous injection of 85 mg/kg ISO. Depression was developed by a 7-week chronic mild stress (CMS) challenge. Behavioral test was conducted before and during the experiment. Echocardiography and biochemical analysis were carried out after 7 weeks of CMS challenge. RESULTS: After 7 weeks of experiment, depression-like behaviors were observed in all the groups except for control and KXS groups, and KXS treatment dramatically increased open-field test scores and sucrose consumption (P < 0.01 vs. model group). Echocardiography and biochemical analysis showed that KXS treatment could improve levels of ejection fraction (EF) and fractional shortening (FS), which were reduced by depression and ISO challenge. Meanwhile, KXS treatment significantly decreased the levels of creation kinase MB (CK-MB) and lactate dehydrogenase (LDH), which were increased in the model group. The activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), catalase (CAT) were increased, while the malondialdehyde (MDA) activity was significantly decreased in the KXS group. Moreover, KXS treatment reduced the levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in myocardial tissue compared with the model group. CONCLUSIONS: KXS had antidepressant-like activity and offered cardioprotective effects against ISO-induced myocardial infarction with depression. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7481476/ doi: 10.3389/fphar.2020.561817 id: cord-344411-lkgcxjya author: Huang, Qiqi title: The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens date: 2017-06-01 words: 5331.0 sentences: 265.0 pages: flesch: 52.0 cache: ./cache/cord-344411-lkgcxjya.txt txt: ./txt/cord-344411-lkgcxjya.txt summary: title: The relationship between liver-kidney impairment and viral load after nephropathogenic infectious bronchitis virus infection in embryonic chickens Abstract To examine the relationship of impairments of the liver and kidney with viral load after nephropathogenic infectious bronchitis virus (NIBV) infection in embryonic chickens, 120 specific-pathogen-free Leghorn embryonated chicken eggs were randomly divided into two groups (infected and control), with three replicates per group and 20 eggs in each replicate. This study attempted to infect embryonic chickens with NIBV and determine the plasma liver and kidney function indices and the tissue viral loads and to explore the relationships of the impairments in the liver and kidney with viral load. Our study demonstrated that liver and kidney damage were strongly related to the viral loads of the tissues following nephropathogenic infectious bronchitis virus infection in embryonic chickens. abstract: Abstract To examine the relationship of impairments of the liver and kidney with viral load after nephropathogenic infectious bronchitis virus (NIBV) infection in embryonic chickens, 120 specific-pathogen-free Leghorn embryonated chicken eggs were randomly divided into two groups (infected and control), with three replicates per group and 20 eggs in each replicate. The eggs in the infected and control groups were challenged with 0.2 mL of 105.5 ELD50 NIBV and sterile saline solution, respectively. The embryonic chickens’ plasma and liver and kidney tissues were collected at 1, 3, and 5 days post-inoculation (dpi), the liver and kidney functional parameters were quantified, and the tissue viral loads were determined with real-time PCR. The results showed that plasma potassium, sodium, chlorine, magnesium, calcium, and phosphorus levels were increased. The infected group exhibited significantly higher plasma uric acid, blood urea nitrogen, and creatinine levels than the control group at 3 dpi. The plasma concentrations of aspartate aminotransferase and alanine aminotransferase were significantly increased in the infected group. The total protein, albumin, and globulin levels in the infected group were significantly lower than those in the control group. The liver-kidney viral load in the infected group peaked at 3 dpi, at which time the kidney viral load was significantly higher than that of the liver. Our results indicated that NIBV infection caused liver and kidney damage in the embryonic chickens, and the results also demonstrated that the liver and kidney damage was strongly related to the tissue viral load following NIBV infection in embryonic chickens. url: https://www.ncbi.nlm.nih.gov/pubmed/28108730/ doi: 10.3382/ps/pew455 id: cord-317344-wznzmssz author: Iannitti, T. title: Therapeutical use of probiotic formulations in clinical practice date: 2010-06-23 words: 24517.0 sentences: 1157.0 pages: flesch: 44.0 cache: ./cache/cord-317344-wznzmssz.txt txt: ./txt/cord-317344-wznzmssz.txt summary: Now we are going to report some of the several studies involving the use of probiotic formulations to evaluate their efficacy for the treatment of allergic diseases basing on their ability to change either the composition and/or the metabolic activities of the microbiota or modulate immune system reactivity in a way that benefits health. One hundred and sixteen patients with IBS fulfilling the Rome II criteria were randomized in a parallel group, double-blind study to receive a placebo or a probiotic combination (1  10 10 cfu) once daily for four weeks. This randomized double-blind placebo-controlled study aimed at determining the efficacy of a probiotic drink containing Lactobacillus for the prevention of any diarrhea associated with antibiotic use and caused by Clostridium difficile. abstract: BACKGROUND & AIMS: The spreading of gastrointestinal diseases is growing all over the world. Although for some of them an effective therapeutic approach has been found, palliation rather than cure is very frequent due to a partial knowledge of their aethiology and pathogenesis. This review, analyzing the main clinical studies, aims at being a state of the art update of the use of probiotic formulations in daily practice. METHODS: In this review we include all the most significant clinical trials involving the use of probiotic formulations for the treatment of several pathologies. RESULTS: Dysbiosis has been observed in irritable bowel syndrome patients. Probiotics may exert a beneficial effect on Crohn’s disease affected patients who have shown gut microbiota antigens and altered wall permeability. Moreover some probiotic formulations seem to enhance the therapy for Helycobacter Pylori reducing its pathogenic potential. Intestinal ecology imbalance has been also linked to cancer induction, allergy, skin and urogenital diseases. In addition probiotics administration seems to be particularly useful to ease post-operative complications. CONCLUSION: Further future clinical trials, involving large numbers of patients, will be mandatory to achieve definite evidence of the preventive and curative role of probiotics in medical practice. url: https://www.ncbi.nlm.nih.gov/pubmed/20576332/ doi: 10.1016/j.clnu.2010.05.004 id: cord-294839-qxn22td0 author: Ibfelt, T. title: Effect of cleaning and disinfection of toys on infectious diseases and micro-organisms in daycare nurseries date: 2014-12-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The rising number of children in daycare nurseries increases opportunities for the transmission of infectious diseases. Pathogens may be transmitted directly from child to child via sneezing, coughing and touching, or indirectly via the environment. Toys are among the fomites with the highest pathogen load, but their role in disease transmission is unknown. AIM: To determine if washing and disinfection of toys can reduce sickness absence and microbial pathogen load in the nursery environment. METHODS: Twelve nurseries (caring for 587 children) were randomized to intervention and control groups. The intervention consisted of washing and disinfection of toys and linen every two weeks for three months by a commercial cleaning company. The extent and causes of sickness absence among the children were recorded in both groups before and after introduction of the intervention. Ten sampling points in each nursery were examined for bacteria and respiratory viruses. RESULTS: The presence of respiratory virus DNA/RNA was widespread, but very few pathogenic bacteria were found in the environment. The intervention reduced the presence of adenovirus [odds ratio (OR) 2.4, 95% confidence interval (CI) 1.1–5.0], rhinovirus (OR 5.3, 95% CI 2.3–12.4) and respiratory syncytial virus (OR 4.1, 95% CI 1.5–11.2) compared with the control group, but the intervention had no effect on sickness absence or disease patterns in the nurseries. CONCLUSION: Although cleaning and disinfection of toys every two weeks can decrease the microbial load in nurseries, it does not appear to reduce sickness absence among nursery children. url: https://www.sciencedirect.com/science/article/pii/S0195670114003429 doi: 10.1016/j.jhin.2014.10.007 id: cord-285323-473d7zvg author: Jang, Hyesun title: Altered pro-inflammatory cytokine mRNA levels in chickens infected with infectious bronchitis virus date: 2013-09-01 words: 4802.0 sentences: 228.0 pages: flesch: 49.0 cache: ./cache/cord-285323-473d7zvg.txt txt: ./txt/cord-285323-473d7zvg.txt summary: The KIIa genotype (Kr/ADL110002/2011) induced clinical signs accompanied by the excessive production of pro-inflammatory cytokines and a higher viral load. In chickens infected with this isolate, simultaneous peaks in the viral copy number and cytokine production were observed at 7 dpi in the trachea and 9 d postinoculation in the kidney. In chickens infected with this isolate, simultaneous peaks in the viral copy number and cytokine production were observed at 7 dpi in the trachea and 9 d postinoculation in the kidney. In this study, we observed changes in the transcriptional levels of 3 pro-inflammatory cytokines that are known to be involved in the innate immune response in chickens (Hong et al., 2006; Davison et al., 2008) after inoculation with 2 IB isolates. On the other hand, an active infection of the ChVI genotype isolate kr/ADL120003/2012, which resulted in an increase in serum AGP level at 9 dpi (Table 3) , evoked only a limited range of pro-inflammatory responses. abstract: Infectious bronchitis virus (IBV) replicates primarily in the respiratory tract and grows in various organs in chickens, with or without pathological effects. The diversity of this virus has been verified by sequence analysis of the S1 glycoprotein gene, but this method must be supplemented with further analysis for characterization of the agent. To increase our understanding of the pathogenesis of the disease caused by this virus, we investigated the response of chickens to 2 IBV with different genotypes, KIIa and ChVI. The clinical signs induced by the viruses were observed. In addition, the mRNA levels of the pro-inflammatory cytokines, IL-6, IL-1β, and lipopolysaccharide-induced tumor necrosis factor-α factor and the serum levels of α(1)-acid glycoprotein, which is a major acute phase protein, were measured. The KIIa genotype (Kr/ADL110002/2011) induced clinical signs accompanied by the excessive production of pro-inflammatory cytokines and a higher viral load. In chickens infected with this isolate, simultaneous peaks in the viral copy number and cytokine production were observed at 7 dpi in the trachea and 9 d postinoculation in the kidney. On the other hand, the chickens infected with the ChVI genotype (Kr/ADL120003/2012) did not show a response other than a mild upregulation of cytokines at 1 d postinoculation, which appears to indicate the invasion of the virus. In summary, we confirmed a differential innate response following infection with distinct IBV. We hypothesize that an excessive innate response contributes to the scale of the pathophysiologic effect in chickens. url: https://api.elsevier.com/content/article/pii/S0032579119394404 doi: 10.3382/ps.2013-03116 id: cord-299691-jton1oig author: Jové-Blanco, A. title: Video discharge instructions for pediatric gastroenteritis in an emergency department: a randomized, controlled trial date: 2020-10-08 words: 3433.0 sentences: 182.0 pages: flesch: 51.0 cache: ./cache/cord-299691-jton1oig.txt txt: ./txt/cord-299691-jton1oig.txt summary: The aim was to evaluate if the addition of video discharge instructions (VDIs) to usual verbal information improved the comprehension of information provided to caregivers of patients who consult for acute gastroenteritis (AGE). This study was designed to evaluate if the addition of VDI to usual verbal information improved the comprehension of the information provided to caregivers of patients who consult in PED for acute gastroenteritis. In the first group of subjects (control group), caregivers received, after completing the test and prior to discharge, the usual verbal information and recommendations about AGE following the guidelines of the Spanish Society of Pediatric Emergencies [16] . This test also included questions about subsequent visits to either emergency units or outpatient pediatric clinics, satisfaction with the information (caregivers were asked to evaluate information in a score 0-10) and a question about whether they perceived video instructions as potentially useful tool or not. abstract: The aim was to evaluate if the addition of video discharge instructions (VDIs) to usual verbal information improved the comprehension of information provided to caregivers of patients who consult for acute gastroenteritis (AGE). We conducted an open-label, parallel, randomized trial, enrolling patients who consulted for AGE at a tertiary hospital. First, caregivers answered a written test concerning AGE characteristics and management. They were randomly allocated to a control group, which received the usual verbal instructions, or to an intervention group, which additionally received VDI. After discharge, caregivers were contacted by telephone and answered the same test, satisfaction questions, and follow-up information. From September 2019 to March 2020, 139 patients were randomized, 118 completed follow-up. The mean score was 3.13 (SD 1.07) over 5 points in the initial test and 3.96 (SD 0.96) in the follow-up test. Patients in the intervention group had a greater improvement (1.17 points, SD 1.11) than those in the control group (0.47 points, SD 0.94, p < 0.001). In the follow-up test, 49.1% in the intervention group and 18.6% in the control group answered all questions correctly (p < 0.001). There were no significant differences in return visits. Caregivers gave high satisfaction scores regardless of the allocation group. Conclusion: Video instructions improve caregivers’ understanding of discharge information. Trial registration: [NCT04463355, retrospectively registered July 9, 2020]. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00431-020-03827-w) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/33029683/ doi: 10.1007/s00431-020-03827-w id: cord-326431-42luhd4s author: Järvelä, Sanna title: Advocating for group interaction in the age of COVID-19 date: 2020-07-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32837407/ doi: 10.1007/s11412-020-09324-4 id: cord-234996-hah19vmk author: Kabiri, Aliakbar title: How different age groups responded to the COVID-19 pandemic in terms of mobility behaviors: a case study of the United States date: 2020-07-20 words: 3654.0 sentences: 155.0 pages: flesch: 46.0 cache: ./cache/cord-234996-hah19vmk.txt txt: ./txt/cord-234996-hah19vmk.txt summary: In this paper, we attempt to fill the current gap in the literature by examining how different communities with different age groups performed social distancing by following orders such as the national emergency declaration on March 13, as well as how fast they started changing their behavior after the regulations were imposed. For this purpose, we calculated the behavior changes of people in different mobility metrics, such as percentage of people staying home during the study period (March, April, and May 2020), in different age groups in comparison to the days before the pandemic (January and February 2020), by utilizing anonymized and privacy-protected mobile device data. Several aspects of mobility patterns including percentage of people staying at home and social distancing index, have been investigated in this paper to illustrate how different age groups behave during the pandemic. abstract: The rapid spread of COVID-19 has affected thousands of people from different socio-demographic groups all over the country. A decisive step in preventing or slowing the outbreak is the use of mobility interventions, such as government stay-at-home orders. However, different socio-demographic groups might have different responses to these orders and regulations. In this paper, we attempt to fill the current gap in the literature by examining how different communities with different age groups performed social distancing by following orders such as the national emergency declaration on March 13, as well as how fast they started changing their behavior after the regulations were imposed. For this purpose, we calculated the behavior changes of people in different mobility metrics, such as percentage of people staying home during the study period (March, April, and May 2020), in different age groups in comparison to the days before the pandemic (January and February 2020), by utilizing anonymized and privacy-protected mobile device data. Our study indicates that senior communities outperformed younger communities in terms of their behavior change. Senior communities not only had a faster response to the outbreak in comparison to young communities, they also had better performance consistency during the pandemic. url: https://arxiv.org/pdf/2007.10436v2.pdf doi: nan id: cord-014538-6a2pviol author: Kamilia, Chtara title: Proceedings of Réanimation 2017, the French Intensive Care Society International Congress date: 2017-01-10 words: 61068.0 sentences: 3463.0 pages: flesch: 49.0 cache: ./cache/cord-014538-6a2pviol.txt txt: ./txt/cord-014538-6a2pviol.txt summary: Other parameters that were significantly different between the patients who died and those who survived were an advanced age, an elevated IGS II score at hospital admission, an elevated SOFA score at study entry, a late healthcare-associated infection and several biological variables: a high C reactive protein, low albumin and prealbumin and a poor percent of monocytes expressing HLA-DR, all measured at day 7. Parameters collected were demographic features, comorbidities, regular treatment, dyspnea assessed by the MRC scale, initial clinical severity reflected by SAPS II and APACHE II scores, modalities and ICU admission deadlines, initial arterial blood gas analysis, management of patients in the ICU (ventilation modalities, prescription of antibiotics, use of vasoactive drugs) and their outcomes (incidence of nosocomial infections and their sites, length of stay and ICU mortality). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5225389/ doi: 10.1186/s13613-016-0224-7 id: cord-348785-f67amppy author: Kapicibaşi, Hasan Oğuz title: Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model date: 2020-07-13 words: 2693.0 sentences: 171.0 pages: flesch: 50.0 cache: ./cache/cord-348785-f67amppy.txt txt: ./txt/cord-348785-f67amppy.txt summary: PURPOSE: This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Based on the known positive and negative effects of ozone, in our study we aimed to assess the effect of two different doses of ozone therapy added to antibiotic treatment in an experimental sepsis model induced with Escherichia coli on the histopathologic findings observed in the inflammatory process in the lungs. In an experimental necrotizing pancreatitis model, ozone therapy was seen to be more effective to reduce oxidative stress levels, tissue injury and bacterial translocation rates compared to hyperbaric oxygen treatment 30 . Data obtained as a result of our study lead to the consideration that ozone therapy administered in addition to antibiotherapy may cause negative effects on lung tissue damaged due to sepsis. abstract: PURPOSE: This experimental sepsis model created with Escherichia coli aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. METHODS: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1(st) group was treated with cefepime, the 2(nd) and 3(rd) groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. RESULTS: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). CONCLUSION: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters. url: https://www.ncbi.nlm.nih.gov/pubmed/32667585/ doi: 10.1590/s0102-865020200060000004 id: cord-048469-xa9a5p0q author: Klune, John R title: HMGB1: Endogenous Danger Signaling date: 2008-04-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: While foreign pathogens and their products have long been known to activate the innate immune system, the recent recognition of a group of endogenous molecules that serve a similar function has provided a framework for understanding the overlap between the inflammatory responses activated by pathogens and injury. These endogenous molecules, termed alarmins, are normal cell constituents that can be released into the extracellular milieu during states of cellular stress or damage and subsequently activate the immune system. One nuclear protein, High mobility group box-1 (HMGB1), has received particular attention as fulfilling the functions of an alarmin by being involved in both infectious and non-infectious inflammatory conditions. Once released, HMGB1 signals through various receptors to activate immune cells involved in the immune process. Although initial studies demonstrated HMGB1 as a late mediator of sepsis, recent findings indicate HMGB1 to have an important role in models of non-infectious inflammation, such as autoimmunity, cancer, trauma, and ischemia reperfusion injury. Furthermore, in contrast to its pro-inflammatory functions, there is evidence that HMGB1 also has restorative effects leading to tissue repair and regeneration. The complex functions of HMGB1 as an archetypical alarmin are outlined here to review our current understanding of a molecule that holds the potential for treatment in many important human conditions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2323334/ doi: 10.2119/2008-00034.klune id: cord-007580-qwh8ei60 author: Knopf, Harry L.S. title: Clinical and Immunologic Responses in Patients with Viral Keratoconjunctivitis date: 2014-09-26 words: 5104.0 sentences: 320.0 pages: flesch: 53.0 cache: ./cache/cord-007580-qwh8ei60.txt txt: ./txt/cord-007580-qwh8ei60.txt summary: We had three major goals: to determine the rate of viral recovery from cases of nonepidemic acute or subacute follicular conjunc tivitis; to compare the accuracy of clinical diagnoses with that achieved by culture or serologic studies, or both; and to explore the possible role of serum antibody in the forma tion and maintenance of corneal subepithelial infiltrates. 4 VIRAL KERATOCONJUNCTIVITIS 663 antibody titers to vaccinia, herpes, coxsackievirus A-9, A-16, and A-21, and four strains of acute hemorrhagic conjunctivitis virus were similarly assayed by serum neutraliza tion tests in human diploid fibroblast tissue culture. Table 2* shows the difference between the number of positive isolates ob tained by culturing before or after the eighth * All of the data for the epidemic keratoconjunc tivitis group were published elsewhere, except for the corneal quantitative material in clinical studies.'' day of illness. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119397/ doi: 10.1016/0002-9394(75)90398-0 id: cord-261163-n9tp9nx7 author: Ko, Jae-Hoon title: Serologic responses of 42 MERS-coronavirus-infected patients according to the disease severity date: 2017-10-31 words: 3140.0 sentences: 144.0 pages: flesch: 44.0 cache: ./cache/cord-261163-n9tp9nx7.txt txt: ./txt/cord-261163-n9tp9nx7.txt summary: Abstract We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). Based on these findings, we evaluated serologic response of 42 MERS-CoV-infected patients according to the disease severity to investigate potential role of serodiagnostic parameters as prognostic markers. Although different seroconversion rates depending on disease severity can be inferred from previous serologic investigation (Min et al., 2016) , the number of evaluated MERS patients was limited to 14 and neutralization testing was not performed. Serologic response was delayed in Group 3 patients, and negative seroconversion by the third week of illness was associated with fatal outcome among patients with MERS pneumonia (HR 27.83, 95% CI 2.76-280.21, P = 0.005). abstract: Abstract We evaluated serologic response of 42 Middle East respiratory syndrome coronavirus (MERS-CoV)-infected patients according to 4 severity groups: asymptomatic infection (Group 0), symptomatic infection without pneumonia (Group 1), pneumonia without respiratory failure (Group 2), and pneumonia progressing to respiratory failure (Group 3). None of the Group 0 patients showed seroconversion, while the seroconversion rate gradually increased with increasing disease severity (0.0%, 60.0%, 93.8%, and 100% in Group 0, 1, 2, 3, respectively; P = 0.001). Group 3 patients showed delayed increment of antibody titers during the fourth week, while Group 2 patients showed robust increment of antibody titer during the third week. Among patients having pneumonia, 75% of deceased patients did not show seroconversion by the third week, while 100% of the survived patients were seroconverted (P = 0.003). url: https://www.sciencedirect.com/science/article/pii/S0732889317302213 doi: 10.1016/j.diagmicrobio.2017.07.006 id: cord-259996-uhrhsrky author: Lee, Seul Bee title: Cardiac Function in Kawasaki Disease Patients with Respiratory Symptoms date: 2015-07-16 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND AND OBJECTIVES: Respiratory symptoms are often observed in children with Kawasaki disease (KD) during the acute phase. The association of respiratory viruses in children with KD was investigated using multiplex reverse transcriptase-polymerase chain reaction (RT-PCR) and tissue Doppler echocardiography. SUBJECTS AND METHODS: 138 KD patients were included from January 2010 to June 2013. We compared 3 groups (group 1: n=94, KD without respiratory symptoms; group 2: n=44, KD with respiratory symptoms; and group 3: n=50, febrile patients with respiratory symptoms). Laboratory data were obtained from each patient including N-terminal pro-brain natriuretic peptide (NT-proBNP). Echocardiographic measurements were compared between group 1 and group 2. RT-PCR was performed using nasopharyngeal secretion to screen for the presence of 14 viruses in groups 2 and 3. RESULTS: The incidence of KD with respiratory symptoms was 31.8%. The duration of fever was significantly longer, and coronary artery diameter was larger in group 2 than in group 1. Tei index was significantly higher and coronary artery diameter larger in group 2 than group 1. Coronary artery diameter, C-reactive protein levels, platelet count, alanine aminotransferase levels, and NT-pro BNP levels were significantly higher and albumin levels lower in group 2 compared with group 3. CONCLUSION: NT-pro BNP was a valuable diagnostic tool in differentiating KD from other febrile viral respiratory infections. Some viruses were more frequently observed in KD patients than in febrile controls. Tei index using tissue Doppler imaging was increased in KD patients with respiratory symptoms. url: https://www.ncbi.nlm.nih.gov/pubmed/26240586/ doi: 10.4070/kcj.2015.45.4.317 id: cord-286779-si3qml42 author: Li, Hai-yan title: Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks date: 2020-06-04 words: 5077.0 sentences: 263.0 pages: flesch: 48.0 cache: ./cache/cord-286779-si3qml42.txt txt: ./txt/cord-286779-si3qml42.txt summary: title: Modulation of Gut Microbiota, Short-Chain Fatty Acid Production, and Inflammatory Cytokine Expression in the Cecum of Porcine Deltacoronavirus-Infected Chicks Results obtained using 16S rRNA sequencing showed that infection with PDCoV strain HNZK-02 significantly altered the composition of chick gut microbiota, with the reduced abundance of Eisenbergiella and Anaerotruncus genera at 5 days post-inoculation (dpi) (P < 0.05), and an increased abundance of Alistipes genus at 17 dpi (P < 0.05). The expression of inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and interleukin-10) was increased in the cecum tissue and serum of the PDCoV HNZK-02–infected chicks when detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Further analysis showed significant correlation between bacterial genera and SCFAs or inflammatory cytokines expression in cecum of the PDCoV infected chicks. Three hundred and seventeen OTUs of the total gut microbial richness (375) were shared between the samples of mock and PDCoV HNZK-02 groups at 17 dpi (Figure 1 ). abstract: Porcine deltacoronavirus (PDCoV) is a novel swine enteropathogenic coronavirus that causes watery diarrhea and induces proinflammatory cytokine responses in piglets. Our previous research showed that the specific-pathogen-free (SPF) chicks exhibited mild diarrhea and low fecal viral shedding, along with cecum lesions after PDCoV infection. Disturbances in the homeostasis of the gut microbiota have been associated with various diseases. We aimed to explore the effects of PDCoV infection on chick gut microbiota, short-chain fatty acid (SCFAs) production, and inflammatory cytokine expression in chicks, and also to investigate the relationship between gut microbiota and SCFAs or inflammatory cytokine expression of the PDCoV-infected chicks. Results obtained using 16S rRNA sequencing showed that infection with PDCoV strain HNZK-02 significantly altered the composition of chick gut microbiota, with the reduced abundance of Eisenbergiella and Anaerotruncus genera at 5 days post-inoculation (dpi) (P < 0.05), and an increased abundance of Alistipes genus at 17 dpi (P < 0.05). The production of SCFAs in the cecum of PDCoV HNZK-02–infected chicks, including acetic acid, propionic acid, and butyric acid, decreased in all cases. The expression of inflammatory cytokines (interferon-γ, tumor necrosis factor-α, and interleukin-10) was increased in the cecum tissue and serum of the PDCoV HNZK-02–infected chicks when detected by quantitative real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively. Further analysis showed significant correlation between bacterial genera and SCFAs or inflammatory cytokines expression in cecum of the PDCoV infected chicks. These findings might provide new insight into the pathology and physiology of PDCoV in chicks. url: https://www.ncbi.nlm.nih.gov/pubmed/32582042/ doi: 10.3389/fmicb.2020.00897 id: cord-343418-519vkzci author: Li, Hao title: Study on the Performance Degradation of Sandstone under Acidification date: 2020-10-21 words: 3993.0 sentences: 210.0 pages: flesch: 52.0 cache: ./cache/cord-343418-519vkzci.txt txt: ./txt/cord-343418-519vkzci.txt summary: X-ray diffraction qualitative analysis of the composition and concentration of ions shows that the formation of white precipitates is citric acid and Mg promotes the conversion of amorphous calcium carbonate to high-crystallinity calcite, forming a white precipitate. Due to the influence of the Corona Virus Disease 2019 (COVID-19), the research period was extended to 93 days, and it was unexpectedly concluded that the citric acid action promoted the precipitation of regular carbonate in the sandstone, resulting in calcium crystals, and an experimental analysis of the reasons for precipitation. Group 5 shows a relatively high ion content, indicating that hydrochloric acid and acetic acid both react with minerals in the sandstone, although the cores used in groups 4 and 7 are the most damaged due to the formation of precipitated substances by weak acids. abstract: [Image: see text] In most oilfields, acid fracturing is widely used for oil production. Understanding the relationship between the individual factors (i.e., carbonate rock types, acid rock reaction kinetics, and deterioration of rock mechanical properties) can provide practical guidelines that can be used for the design and optimization of acid fracturing operation. This paper takes hydrochloric acid, acetic acid, and citric acid as the main research objects and carries out acidification experiments on sandstone in Changqing Oilfield, China. In addition, the effects of tribasic, dibasic, and monobasic acids on the mechanical properties of sandstone were studied. Results show that in this study area, the most obvious effect was seen with the use of dibasic acids (hydrochloric acid + acetic acid), which effectively reduced the sample quality, uniaxial compressive strength, and elastic modulus. Citric acid and Mg promote the conversion of amorphous calcium carbonate to high-crystallinity calcite, forming a white precipitate. Furthermore, it is found by scanning electron microscopy analysis that experimental group 5 (hydrochloric acid + acetic acid) has the most ideal rock erosion effect. Inductively coupled plasma emission spectrometry analysis shows that the acid rock is present in the solution. X-ray diffraction qualitative analysis of the composition and concentration of ions shows that the formation of white precipitates is citric acid and Mg promotes the conversion of amorphous calcium carbonate to high-crystallinity calcite, forming a white precipitate. The findings of this study can help to better understand the erosion, failure state, and failure mechanism of different acid types on sandstone, which may provide certain references and guidelines for sandstone acid fracturing oil production. url: https://doi.org/10.1021/acsomega.0c04312 doi: 10.1021/acsomega.0c04312 id: cord-301687-wadf3c3i author: Li, Yan title: Association of “initial CT” findings with mortality in older patients with coronavirus disease 2019 (COVID-19) date: 2020-06-10 words: 3441.0 sentences: 184.0 pages: flesch: 56.0 cache: ./cache/cord-301687-wadf3c3i.txt txt: ./txt/cord-301687-wadf3c3i.txt summary: Although radiation dose [7, 8] needs to be considered, chest CT as reported previously plays an important role in disease diagnosis, monitoring, severity stratification, and evaluation of treatment response in patients with COVID-19 [9, 10] , which goes beyond the ability of reverse transcription polymerase chain reaction (RT-PCR). In this single-center study, aiming to further identify the value of chest CT in clinical management of COVID-19, we evaluated the association of initial chest CT findings obtained at admission with severity and clinical outcomes in older patients with COVID-19. In the survival (n = 52) and death (n = 46) groups, the patients were sub-grouped based on the time interval between symptom onset and the "initial CT" scan: subgroup1 (interval ≤ 5 days), subgroup2 (interval between 6 and 10 days), and subgroup3 (interval > 10 days). In subgroup1 and subgroup2, patients underwent CT scans within 10 days after symptom onsets, where the mean score of "initial CT" was statistically higher in the death group than in the survival group. abstract: OBJECTIVES: To investigate the association of chest CT findings with mortality in clinical management of older patients. METHODS: From January 21 to February 14, 2020, 98 older patients (≥ 60 years) who had undergone chest CT scans (“initial CT”) on admission were enrolled. Manifestation and CT score were compared between the death group and the survival group. In each group, patients were sub-grouped based on the time interval between symptom onset and the “initial CT” scan: subgroup1 (interval ≤ 5 days), subgroup2 (interval between 6 and 10 days), and subgroup3 (interval > 10 days). Adjusted ROC curve after adjustment for age and gender was applied. RESULTS: Consolidations on CT images were more common in the death group (n = 46) than in the survival group (n = 52) (53.2% vs 32.0%, p < 0.001). For subgroup1 and subgroup2, a higher mean CT score was found for the death group (33.0 ± 17.1 vs 12.9 ± 8.7, p < 0.001; 38.8 ± 12.3 vs 24.3 ± 11.9, p = 0.002, respectively) and no significant difference of CT score was identified with respect to subgroup3 (p = 0.144). In subgroup1, CT score of 14.5 with a sensitivity of 83.3% and a specificity of 77.3% for the prediction of mortality was an optimal cutoff value, with an adjusted AUC of 0.881. In subgroup2, CT score of 27.5 with a sensitivity of 87.5% and a specificity of 70.6% for the prediction of mortality was an optimal cutoff value, with an adjusted AUC of 0.895. CONCLUSIONS: “Initial CT” scores may be useful to speculate prognosis and stratify patients. Severe manifestation on CT at an early stage may indicate poor prognosis for older patients with COVID-19. KEY POINTS: • Severe manifestation on CT at an early stage may indicate poor prognosis for older patients with COVID-19. • Radiologists should pay attention to the time interval between symptom onsets and CT scans of patients with COVID-19. • Consolidations on CT images were more common in death patients than in survival patients. url: https://doi.org/10.1007/s00330-020-06969-5 doi: 10.1007/s00330-020-06969-5 id: cord-004342-9uok77wb author: Lin, Chun-Yu title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience date: 2020-02-14 words: 3003.0 sentences: 160.0 pages: flesch: 36.0 cache: ./cache/cord-004342-9uok77wb.txt txt: ./txt/cord-004342-9uok77wb.txt summary: title: Elderly versus non-elderly patients undergoing surgery for left-sided native valve infective endocarditis: A 10-year institutional experience This retrospective study aimed to clarify the shortand mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. In this single-centre study, a comparative cohort of patients who underwent surgical treatment for active LSNIE is presented, which includes 38 elderly patients aged >65 years. Due to the increase in average life expectancy and the higher incidence of cardiovascular disease with advancing age, more elderly patients nowadays present for cardiac surgery 22 . Therefore, we suggest that a guideline-directed surgical strategy according to the presence of complications, which include embolism events, large vegetation, heart failure, or uncontrolled infection, would be beneficial to improve the mid-term outcomes of elderly patients with LSNIE. abstract: This retrospective study aimed to clarify the short- and mid-term outcomes of elderly patients who underwent surgery to treat left-sided native valve infective endocarditis (LSNIE). Between July 2005 and September 2015, 179 patients underwent surgical treatment for active LSNIE at a single institution. Patients were classified into two groups: ≥65 years (elderly group) and <65 years (non-elderly group). Clinical features, surgical information, postoperative complications, and three-year survival rates were compared. The average ages were 74.2 ± 6.4 and 45.2 ± 12.6 years in the elderly and non-elderly groups, respectively. The elderly group had a higher predicted mortality rate and a lower incidence of preoperative septic emboli-related complications. Echocardiographic assessments of infected valves were generally homogenous between the groups. The elderly patients had a higher in-hospital mortality rate than the non-elderly patients (26.3% vs. 5.7%, P = 0.001). For patients who survived to discharge, the three-year cumulative survival rates were 75.0% ± 8.2% and 81.2% ± 3.4% in the elderly and non-elderly groups, respectively (P = 0.484). In conclusion, elderly patients are at a higher risk of in-hospital mortality after surgery for LSNIE. However, once elderly patients are stabilized by surgical treatment and survive to discharge, the mid-term outcomes are promising. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7021775/ doi: 10.1038/s41598-020-59657-1 id: cord-253308-wgseqk4t author: Liu, Chang title: PCV cap proteins fused with calreticulin expressed into polymers in Escherichia coli with high immunogenicity in mice date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Porcine circovirus type 2 (PCV2) is the main causative agent of porcine circovirus diseases (PCVDs) which causes huge yearly economic losses in the swine industry. Capsid protein (Cap) is the major structural protein of PCV2 that can induce a protective immune response. Therefore, developing a novel and safe subunit vaccine against PCV2 infection is needed. RESULTS: In this study, the Cap gene was bound to the truncated calreticulin (CRT) (120–250 aa/120–308 aa) at the N/C terminal, and then the CRT-Cap fusion genes were expressed in Escherichia coli (E.coli). The size-exclusion chromatography and dynamic light scattering (DLS) data showed that the purified recombinant CRT-Cap fusion protein (rP5F) existed in the form of polymers. Immunization with rP5F stimulated high levels of PCV2 specific antibody and neutralization antibody in mice, which were almost identical to those induced by the commercial subunit and inactivated vaccines. The lymphocyte proliferation and cytokine secretion were also detected in rP5F immunized mice. According to the results of PCV2-challenge experiment, the virus loads significantly decreased in mice immunized with rP5F. The data obtained in the current study revealed that rP5F had the potential to be a subunit vaccine candidate against PCV2 in the future. CONCLUSIONS: We have successfully expressed Cap-CRT fusion proteins in E.coli and optimized rP5F could form into immunogenic polymers. Mice immunized with rP5F efficiently induced humoral and part of cellular immune responses and decreased the virus content against PCV2-challenge, which suggested that rF5P could be a potential subunit vaccine candidate. url: https://doi.org/10.1186/s12917-020-02527-9 doi: 10.1186/s12917-020-02527-9 id: cord-305092-q4tlj1jd author: Lu, Jingjing title: Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China date: 2020-08-29 words: 1210.0 sentences: 74.0 pages: flesch: 51.0 cache: ./cache/cord-305092-q4tlj1jd.txt txt: ./txt/cord-305092-q4tlj1jd.txt summary: title: Clinical characteristics and factors affecting the duration of positive nucleic acid test for patients of COVID‐19 in XinYu, China The aim of this study was to articulate the clinical characteristics of COVID‐19 and to reveal possible factors that may affect the persistent time of positive SARS‐CoV‐2 nucleic acid test, so as to identify which patients may deteriorate or have poor prognoses as early as possible. RESULTS: In this study, patients were divided into two groups based on whether their SARS‐CoV‐2 nucleic acid tests in respiratory specimens turn negative within (Group Rapid or Group R) or over (Group Slow or Group S) a week. Clinical characteristics of COVID-19 include the exposure history and typical systemic symptoms such as fever, cough, fatigue, decreased WBC and lymphocyte counts, and infiltration in both lower lobes on CT imaging. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study abstract: BACKGROUND: The outbreak of a new coronavirus, COVID‐19, which was earliest reported in Wuhan, China, is now transmitting throughout the world. The aim of this study was to articulate the clinical characteristics of COVID‐19 and to reveal possible factors that may affect the persistent time of positive SARS‐CoV‐2 nucleic acid test, so as to identify which patients may deteriorate or have poor prognoses as early as possible. METHODS: Retrospective cohort study was carried out on 47 patients with confirmed COVID‐19 infection admitted to XinYu People's Hospital of JiangXi Province. Epidemiological, demographic, clinical, laboratorial, management, treatment, and outcome data were also collected and analyzed. RESULTS: In this study, patients were divided into two groups based on whether their SARS‐CoV‐2 nucleic acid tests in respiratory specimens turn negative within (Group Rapid or Group R) or over (Group Slow or Group S) a week. There was no significant difference in age, sex, travel or exposure history, and smoking history between the two groups. Forty‐two patients had been observed with comorbidities. Similar clinical manifestations, for instance fever, cough, sputum, and fatigue, have been observed among patients in both groups, except that patients in Group S were obviously more likely to get fatigue than patients in Group R. Both groups had shown decrease in white blood cell or lymphocyte counts. Chest X‐ray or computed tomography scan showed unilateral or bilateral infiltrates. High proportion in both groups has used nasal cannula (89.47% vs. 85.71%) to inhale oxygen. 10.53% of Group S have applied high‐flow nasal cannula, while Group R used none. The current treatment is mainly antibiotics, antiviral, and traditional Chinese medicine, while a couple of patients has used methylprednisolone. Only 1 patient out of both groups got even worse despite this active treatment. CONCLUSION: Clinical characteristics of COVID‐19 include the exposure history and typical systemic symptoms such as fever, cough, fatigue, decreased WBC and lymphocyte counts, and infiltration in both lower lobes on CT imaging. Among them, fatigue appears to be an important factor that affects the duration of positive SARS‐CoV‐2 nucleic acid test in respiratory specimens. url: https://www.ncbi.nlm.nih.gov/pubmed/32860649/ doi: 10.1002/jcla.23534 id: cord-344121-k58c0jf3 author: Lundgren, A.-L. title: Neurological disease and encephalitis in cats experimentally infected with Borna disease virus date: 1997 words: 6161.0 sentences: 340.0 pages: flesch: 52.0 cache: ./cache/cord-344121-k58c0jf3.txt txt: ./txt/cord-344121-k58c0jf3.txt summary: Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD. Of the cats in group II (cats inoculated with feline BDV), cat 6 had a few antigen-containing neurons and glial cells in the laterobasal temporal cortex, close to a region with several adventitial cuffs. abstract: Barrier-bred cats were inoculated intracerebrally with either the rabbit-adapted Borna disease virus (BDV) strain V or a newly isolated feline BDV, obtained from a cat with natural staggering disease (SD). Three out of eight inoculated cats developed neurological signs and non-suppurative encephalitis; all three recovered from the acute stage of disease. Sero-conversion and the development of neutralizing antibodies occurred in all of the virus-inoculated cats. In addition, cats inoculated with feline BDV showed an early peripheral T cell response not present in cats inoculated with BDV strain V, suggesting that the feline virus exerted a more vigorous effect on the immune system. Using immunohistochemistry and a reverse transcriptase-polymerase chain reaction assay, BDV-specific antigen and nucleic acid could be demonstrated in brain samples from each cat with encephalitis, showing that incomplete viral clearance was probably responsible for the maintenance of inflammation. The successful induction of neurological signs and encephalitis in one cat infected with feline BDV, together with the detection of BDV-specific antigen and nucleic acid in the brain, provides strong evidence for the notion that BDV is the etiological agent behind feline SD. url: https://www.ncbi.nlm.nih.gov/pubmed/9113204/ doi: 10.1007/s004010050630 id: cord-010530-w8ir0e07 author: MOURA, HERCULES title: Acanthamoeba healyi N. Sp. and the Isoenzyme and Immunoblot Profiles of Acanthamoeba spp., Groups 1 and 3 date: 2007-05-01 words: 4382.0 sentences: 269.0 pages: flesch: 62.0 cache: ./cache/cord-010530-w8ir0e07.txt txt: ./txt/cord-010530-w8ir0e07.txt summary: ABSTRACT Two strains of Acanthamoeba isolated from human brain tissue and a strain of Acanthamoeba isolated from a fish were compared with 10 species of Acanthamoeba belonging to groups 1, 2 and 3 based on their isoenzyme profiles and antigenic characteristics. The isoenzymes and antigens were electrophoretically separated on polyacrylamide gradient gels, and the patterns obtained were compared after appropriate staining for particular enzymes and reactivities with homologous and heterologous rabbit anti‐Acanthamoeba antisera. This paper presents the methods used to isolate Acanthamoeba from the CNS of humans and identify them to the species level based on morphologic characteristics and isoenzyme and antigenic profiles. A small piece of the biopsied brain tissue was frozen and sent to the Centers for Disease Control, where Acanthamoeba (CDC: 1283:V013) was isolated on non-nutrient agar plates seeded with Escherichia coli and MRC human lung cell culture [ 131. abstract: ABSTRACT Two strains of Acanthamoeba isolated from human brain tissue and a strain of Acanthamoeba isolated from a fish were compared with 10 species of Acanthamoeba belonging to groups 1, 2 and 3 based on their isoenzyme profiles and antigenic characteristics. A total of 12 enzymes were studied. The isoenzymes and antigens were electrophoretically separated on polyacrylamide gradient gels, and the patterns obtained were compared after appropriate staining for particular enzymes and reactivities with homologous and heterologous rabbit anti‐Acanthamoeba antisera. One of the human strains (CDC:1283:V013) was identified as A. healyi n. sp. because of its unique isoenzyme profiles for 11 of the 12 enzymes tested. The other human isolate was reidentified as A. culbertsoni because its isoenzyme profiles for 10 of 12 enzymes resembled those of A. culbertsoni, Lilly A‐1 strain. Since the isoenzyme profiles and the antigenic patterns of the fish isolate as well were remarkably similar to those of A. royreba, it was considered as a strain of A. royreba. Polyacrylamide gradient gel electrophoresis appears to be a powerful technique for the study of isoenzymes and antigens of Acanthamoeba. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194289/ doi: 10.1111/j.1550-7408.1992.tb04853.x id: cord-324326-q014b5ym author: MURAKAMI, Makoto title: Lipoquality control by phospholipase A(2) enzymes date: 2017-11-10 words: 8260.0 sentences: 556.0 pages: flesch: 45.0 cache: ./cache/cord-324326-q014b5ym.txt txt: ./txt/cord-324326-q014b5ym.txt summary: The phospholipase A(2) (PLA(2)) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. In terms of signal transduction, the phospholipase A 2 (PLA 2 ) reaction, which hydrolyzes the sn-2 position of phospholipids to yield fatty acids and lysophospholipids, has been considered to be of particular importance, since arachidonic acid (AA, C20:4), one of the polyunsaturated fatty acids (PUFAs) released from membrane phospholipids by PLA 2 , is metabolized by cyclooxygenases (COXs) and lipoxygenases (LOXs) to lipid mediators including prostaglandins (PGs) and leukotrienes (LTs), which are often referred to as eicosanoids (Fig. 1) . 36) cPLA 2 C (group IVE PLA 2 ) exhibits a unique transacylase activity that transfers sn-1 fatty acid of PC to an amino residue of phosphatidylethanolamine (PE) to form N-acyl-PE, a precursor of the endocannabinoid lipid mediator N-acylethanolamine. abstract: The phospholipase A(2) (PLA(2)) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. The mammalian genome encodes more than 50 PLA(2)s or related enzymes, which are classified into several subfamilies on the basis of their structures and functions. From a general viewpoint, the PLA(2) family has mainly been implicated in signal transduction, producing bioactive lipid mediators derived from fatty acids and lysophospholipids. Recent evidence indicates that PLA(2)s also contribute to phospholipid remodeling for membrane homeostasis or energy production for fatty acid β-oxidation. Accordingly, PLA(2) enzymes can be regarded as one of the key regulators of the quality of lipids, which I herein refer to as lipoquality. Disturbance of PLA(2)-regulated lipoquality hampers tissue and cellular homeostasis and can be linked to various diseases. Here I overview the current state of understanding of the classification, enzymatic properties, and physiological functions of the PLA(2) family. url: https://www.ncbi.nlm.nih.gov/pubmed/29129849/ doi: 10.2183/pjab.93.043 id: cord-342391-arp07mck author: Magiorkinis, G. title: Phylogenetic analysis of the full‐length SARS‐CoV sequences: Evidence for phylogenetic discordance in three genomic regions date: 2004-09-14 words: 1901.0 sentences: 81.0 pages: flesch: 49.0 cache: ./cache/cord-342391-arp07mck.txt txt: ./txt/cord-342391-arp07mck.txt summary: Evidence based on Bayesian scanning plots and phylogenetic analysis using maximum likelihood (ML) and Bayesian methods indicates that SARS‐CoV, for the largest part of the genome (∼80%), is more closely related to Group II coronaviruses sequences, whereas in three regions in the ORF1ab gene it shows no apparent similarity to any of the previously characterized groups of coronaviruses. Bayesian scanning and subsequent phylogenetic analysis revealed that the SARS-CoV sequence was related more closely to Group II than the other two groups in most of its genome (e.g., at the region spanning amino acid positions 4309-5612 in reference to the murine hepatitis virus ORF1ab gene) (Fig. 1) . This clustering was supported by high quartet puzzling support values and high posterior probabilities under various substitution models, thus suggesting that 80% of the SARS-CoV genomic sequence is related more closely to coronaviruses Group II than any other members of this family. abstract: The origin of the severe acute respiratory syndrome‐coronavirus (SARS‐CoV) remains unclear. Evidence based on Bayesian scanning plots and phylogenetic analysis using maximum likelihood (ML) and Bayesian methods indicates that SARS‐CoV, for the largest part of the genome (∼80%), is more closely related to Group II coronaviruses sequences, whereas in three regions in the ORF1ab gene it shows no apparent similarity to any of the previously characterized groups of coronaviruses. There is discordant phylogenetic clustering of SARS‐CoV and coronaviruses sequences, throughout the genome, compatible with either ancient recombination events or altered evolutionary rates in different lineages, or a combination of both. J. Med. Virol. 74:369–372, 2004. © 2004 Wiley‐Liss, Inc. url: https://www.ncbi.nlm.nih.gov/pubmed/15368527/ doi: 10.1002/jmv.20187 id: cord-239632-dyvhzvmm author: McGuigan, Michael title: Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning date: 2020-08-03 words: 5028.0 sentences: 232.0 pages: flesch: 55.0 cache: ./cache/cord-239632-dyvhzvmm.txt txt: ./txt/cord-239632-dyvhzvmm.txt summary: title: Pandemic modeling and the renormalization group equations: Effect of contact matrices, fixed points and nonspecific vaccine waning Figure 6 : Infections as a function of time for two age groups (0 − 49) and 50+ where there is a nondiagonal contact matrix in the SIRD model describing the interaction between the two age groups during the pandemic. Figure 7 : Deaths as a function of time for two age groups (0 − 49) and 50+ where there is a nondiagonal contact matrix in the SIRD model describing the interaction between the two age groups during the pandemic. We put these features together in models with mixing between different age groups, mixing with different countries and the effect of waning of nonspecific vaccines that were designed for different diseases but can lessen the severity of infection and mortality for a pathogen associated with a pandemic. abstract: In this paper we find common features between the equations that are used for pandemic or epidemic modeling and the renormalization group equations that are used in high energy physics. Some of these features include the relation of contact matrices in pandemic modeling and operator mixing in the renormalization group equations. Another common feature are the use of flow diagrams and the study of fixed points both in pandemic modeling and in evolution under renormalization group equations. We illustrate these relations through the study of some cases of interest to the current COVID-19 pandemic. These include pandemic modeling with mixing between different age groups and also contact matrices associated with contact between countries. For the final example we study the effect on mortality of waning from nonspecific vaccines which are designed to combat different pathogens but nevertheless may lessen the severity and mortality of COVID-19 infections. url: https://arxiv.org/pdf/2008.02149v1.pdf doi: nan id: cord-286539-3sr4djft author: Mentus, Cassidy title: Analysis and Applications of Adaptive Group Testing Methods for COVID-19 date: 2020-04-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Testing strategies for Covid-19 to maximize number of people tested is urgently needed. Recently, it has been demonstrated that RT-PCR has the sensitivity to detect one positive case in a mixed sample 32 cases [9]. In this paper we propose non-adaptive and adaptive group testing strategies based on generalized binary splitting (GBS) [2] where we restrict the group test to the largest group that can be used. The method starts by choosing a group from the population to be tested, performing a test on the combined sample from the entire group and progressively splitting the group further into subgroups. Compared to individual testing at 4% prevalence we save 74% at 1% we save 91% and at 1% we save 97% of tests. We analyze the number of times each sample is used and show the method is still efficient if we resort to testing a case individually if the sample is running low. Abstract In addition we recommend clinical screening to filter out individuals with symptoms and show this leaves us with a population with lower prevalence. Our approach is particularly applicable to vulnerable confined populations such as nursing homes, prisons, military ships and cruise ships. url: https://doi.org/10.1101/2020.04.05.20050245 doi: 10.1101/2020.04.05.20050245 id: cord-312497-6cd7dolj author: Mishra, Anurag title: Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Low- to Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study date: 2020-08-19 words: 2396.0 sentences: 160.0 pages: flesch: 54.0 cache: ./cache/cord-312497-6cd7dolj.txt txt: ./txt/cord-312497-6cd7dolj.txt summary: title: Evaluation of Gasless Laparoscopy as a Tool for Minimal Access Surgery in Lowto Middle-Income Countries: A Phase II Non-Inferiority Randomized Controlled Study The current study compares GAL with conventional Laparoscopic surgeries [COL] for general surgical procedures METHODS: A single-centre, non-blinded randomized control trial [RCT] was conducted to evaluate non inferiority of GAL versus COL at a teaching hospital in New Delhi. The Gas Insufflation Less Laparoscopic Surgeries [GAL] offers a solution to the challenges associated with conventional laparoscopy [COL] . However, considering the ethical issues, we planned a non-inferiority study to compare GAL using Stan Laparoscopy Positioner device [SLP] (Fig 1) with conventional laparoscopy (COL) for general surgical procedures. In a paper form, data was recorded on demographics, clinical profile, operative times, vital signs, use of analgesia, efficiency, procedure safety, patient and surgeon satisfaction. abstract: BACKGROUND: Minimal access surgery [MAS] is not available to most people in the rural areas of Low Middle-Income Countries [LMIC]. This leads to an increase in the morbidity and the economic loss to the poor and the marginalized. The Gasless laparoscopic surgeries [GAL] are possible in rural areas as they could be carried out under spinal-anaesthesia. In most cases, it does not require the logistics of providing gases for pneumoperitoneum and general anaesthesia. The current study compares GAL with conventional Laparoscopic surgeries [COL] for general surgical procedures METHODS: A single-centre, non-blinded randomized control trial [RCT] was conducted to evaluate non - inferiority of GAL versus COL at a teaching hospital in New Delhi. Patients were allocated into two groups and underwent MAS (Cholecystectomies and appendectomies). The procedure was carried out by two surgeons by randomly choosing between GAL and COL. The data was collected by postgraduates and analyzed by a biostatistician. RESULTS: 100 patients who met the inclusion criteria were allocated into two groups. No significant difference was observed in the mean operating time between GAL group (52.9 min) vs COL group (55 minutes) [p=0.3]. The intraoperative vital signs were better in the GAL group [p < 0.05]. The postoperative pain score was slightly higher in the GAL group [p = 0.01]; however, it did not require additional analgesics. CONCLUSIONS: No significant differences were found between the two groups. GAL can be classed as non-inferior compared to COL and has the potential to be adopted in low resource settings. url: https://doi.org/10.1016/j.jamcollsurg.2020.07.783 doi: 10.1016/j.jamcollsurg.2020.07.783 id: cord-355190-ytdw1d5v author: Mok, Chi Chiu title: Trend of Survival of a Cohort of Chinese Patients With Systemic Lupus Erythematosus Over 25 Years date: 2020-09-11 words: 3763.0 sentences: 181.0 pages: flesch: 50.0 cache: ./cache/cord-355190-ytdw1d5v.txt txt: ./txt/cord-355190-ytdw1d5v.txt summary: Organ damage as assessed by the Systemic Lupus International Collaborating Clinics (SLICC) damage index (SDI) and causes of death in the first 10 years of SLE onset was compared between the two groups. Cox regression showed that the age of SLE onset and damage score accrued at 10 years, but not the time period in which SLE was diagnosed, were significantly associated with mortality. Organ damage, mortality, and causes of death in the first 10 years of SLE diagnosis were also compared between the two groups. Covariates included in the model were age of SLE onset, sex, SDI score, renal involvement, ever use of hydroxychloroquine (HCQ) within 10 years of diagnosis, and time period in which patients were diagnosed. Long-term survival of southern Chinese patients with systemic lupus erythematosus: a prospective study of all age-groups Factors associated with damage accrual in patients with systemic lupus erythematosus with no clinical or serological disease activity: a multicentre cohort study abstract: Objectives: To revisit the trend of survival of systemic lupus erythematosus in a cohort of Chinese patients over 25 years. Methods: Patients who fulfilled the 1997 ACR criteria for SLE and were followed in our hospital since 1995 were included. Patients were stratified into two groups according to the year of diagnosis: (1) 1995–2004 and (2) 2005–2018. Survival of patients was studied by Kaplan–Meier analysis. Organ damage as assessed by the Systemic Lupus International Collaborating Clinics (SLICC) damage index (SDI) and causes of death in the first 10 years of SLE onset was compared between the two groups. Cox regression was used to study factors associated with survival. Results: A total of 1,098 SLE patients were registered in our database. After excluding 157 patients diagnosed outside the time period of 1995–2018, 941 patients were studied (92% women). All were ethnic Chinese. The mean age of SLE onset was 35.1 ± 14.4 years, and the mean duration of observation was 13.1 ± 6.6 years. Seventy-seven (8.2%) patients were lost to follow-up. Groups 1 and 2 consisted of 364 and 577 patients, respectively. The mean SDI score at 10 years of disease onset was significantly higher in group 1 than group 2 patients (1.01 ± 1.43 vs. 0.57 ± 0.94; p < 0.01), particularly in the neuropsychiatric, musculoskeletal, and gonadal domains. Within 10 years of SLE onset, 32 (8.8%) patients in group 1 and 25 (4.3%) patients in group 2 died (p = 0.005). The 5- and 10-year cumulative survival rates were 93.6 and 91.0% in group 1 and 96.5 and 94.2% in group 2 patients, respectively (log-rank test p = 0.048). Infection accounted for more than half of the deaths in both groups. More group 1 than group 2 patients died of vascular events, but the difference was not statistically significant. Cox regression showed that the age of SLE onset and damage score accrued at 10 years, but not the time period in which SLE was diagnosed, were significantly associated with mortality. Conclusions: The improvement in survival of our SLE patients is probably related to the accrual of less organ damage in the past 15 years. url: https://www.ncbi.nlm.nih.gov/pubmed/33015102/ doi: 10.3389/fmed.2020.00552 id: cord-342210-r8vxz5vu author: Mukherjee, Pranab K. title: Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections date: 2017-01-14 words: 4853.0 sentences: 247.0 pages: flesch: 49.0 cache: ./cache/cord-342210-r8vxz5vu.txt txt: ./txt/cord-342210-r8vxz5vu.txt summary: We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. In the current study, we evaluated the safety and effectiveness of ARMS-I, a novel intra-oral formulation in the prevention of URIs in a randomized, double-blind, placebo-controlled proof-of-concept clinical trial in healthy adults. abstract: BACKGROUND: Current prevention options for upper respiratory infections (URIs) are not optimal. We conducted a randomized, double-blinded, placebo-controlled pilot clinical trial to evaluate the safety and efficacy of ARMS-I™ (currently marketed as Halo™) in the prevention of URIs. METHODS: ARMS-I is patented novel formulation for the prevention and treatment of influenza, comprising a broad-spectrum antimicrobial agent (cetylpyridinium chloride, CPC) and components (glycerin and xanthan gum) that form a barrier on the host mucosa, thus preventing viral contact and invasion. Healthy adults (18–45 years of age) were randomized into ARMS-I or placebo group (50 subjects each). The drug was sprayed intra-orally (3× daily) for 75 days. The primary objectives were to establish whether ARMS-I decreased the frequency, severity or duration of URIs. Secondary objectives were to evaluate safety, tolerability, rate of virus detection, acceptability and adherence; effect on URI-associated absenteeism and medical visits; and effect of prior influenza vaccination on study outcomes. RESULTS: Of the 94 individuals who completed the study (placebo: n = 44, ARMS-I: n = 50), six presented with confirmed URI (placebo: 4, ARMS-I: 2), representing a 55% relative reduction, albeit this was statistically not significant). Influenza, coronavirus or rhinovirus were detected in three participants; all in the placebo group. Moreover, frequency of post-treatment exit visits was reduced by 55% in ARMS-I compared to the placebo group (N = 4 and 2, respectively). Fever was reported only in the placebo group. ARMS-I significantly reduced the frequency and severity of cough and sore throat, and duration of cough (P ≤ .019 for all comparisons). ARMS-I was safe, well tolerated, had high acceptability and high adherence to medication use. Medical visits occurred only in the placebo group while absenteeism did not differ between the two arms. Prior influenza vaccination had no effect on study outcome. CONCLUSIONS: This randomized proof-of-concept clinical trial demonstrated that ARMS-I tended to provide protection against URIs in the enrolled study participants, while reducing severity and duration of cough and sore throat. A clinical trial with a larger number of study participants is warranted. TRIAL REGISTRATION: ClinicalTrials.gov NCT02644135 (retrospectively registered). ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-016-2177-8) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1186/s12879-016-2177-8 doi: 10.1186/s12879-016-2177-8 id: cord-317410-hc06yo32 author: Muthanna, Abdulrahman title: Clinical Screening Tools to Diagnose Group A Streptococcal Pharyngotonsillitis in Primary Care Clinics to Improve Prescribing Habits date: 2018-12-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This review highlights the clinical scoring tools used for the management of acute pharyngotonsillitis in primary care clinics. It will include the prevalence of group A pharyngotonsillitis among children and adults worldwide and the selective tests employed for diagnosing group A streptococcal pharyngotonsillitis. Pharyngotonsillitis is one of the common reasons for visits to primary care clinics worldwide, and physicians tend to prescribe antibiotics according to the clinical symptoms, which leads to overprescribing antibiotics. This in turn may lead to serious health impacts and severe reactions and may promote antibiotic resistance. These significantly add on to the health care costs. The available information from health organisations and previous studies has indicated the need to manage the diagnosis of pharyngotonsillitis to improve prescribing habits in primary care clinics. url: https://www.ncbi.nlm.nih.gov/pubmed/30914875/ doi: 10.21315/mjms2018.25.6.2 id: cord-274497-tqceazdp author: N. Nuñez, Luis Fabian title: Molecular Characterization and Pathogenicity of Chicken Parvovirus (ChPV) in Specific Pathogen-Free Chicks Infected Experimentally date: 2020-07-25 words: 4123.0 sentences: 192.0 pages: flesch: 47.0 cache: ./cache/cord-274497-tqceazdp.txt txt: ./txt/cord-274497-tqceazdp.txt summary: In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . In the present work, the pathogenicity, viral tissue distribution and molecular characterization of ChPV in chicks from a strain isolated in Brazil were determined with a demonstration of Koch''s postulates according to our previous description [21] . Experimental infections with isolated ChPV (ABU-P1) have demonstrated that the virus causes enteric diseases, resulting mainly in chickens with diarrhea, cloacal pasting, impaired growth, runting and stunting [32] . Lesions were previously described in commercial chicken flocks affected with RSS and reported by our own group [21] ; the duodenal loop presented the same features, demonstrating Koch''s postulates in relation to ChPV and experimentally infected chickens. abstract: Chicken parvovirus (ChPV) is an agent frequently associated with runting stunting syndrome (RSS). This syndrome has been reported in association with ChPV in many countries, including Brazil; however, studies characterizing the virus on a molecular level are scarce, and ChPV pathogenicity in day-old chicks remains unclear. The aim of the present work was to establish the molecular characteristics of ChPV, determine the pathogenicity of ChPV in SPF chicks and detect and quantify ChPV by qPCR in several tissues and chicks of different ages. The experimental challenge was performed at one day of age, and daily and weekly observations were performed and five birds from each experimental group (mock and infected birds) were euthanized to perform the different analysis. ChPV genome copies were detected and quantified by qPCR in gut, spleen, thymus, kidney, pancreas, proventriculus and bursa. Clinically, the infected group presented with diarrhea 24 h post-infection, which persisted until 42 days of age. The small intestine was distended, and its contents were aqueous and foamy. Enteritis and dilated crypts with cyst shapes were observed in intestinal segments. Acute pancreatitis associated with lymphocytic nodules, infiltrating lymphocytes and plasma cells between the pancreatic acinus was observed. Koch’s postulate was demonstrated and the genetic characterization of the VP1 gene showed that the Brazilian ChPV isolate belongs to the ChPV II group. url: https://www.ncbi.nlm.nih.gov/pubmed/32722416/ doi: 10.3390/pathogens9080606 id: cord-306145-5uf0hj6a author: Nalbantoglu, Ozkan Ufuk title: Group testing performance evaluation for SARS-CoV-2 massive scale screening and testing date: 2020-07-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The capacity of the current molecular testing convention does not allow high-throughput and community level scans of COVID-19 infections. The diameter in the current paradigm of shallow tracing is unlikely to reach the silent clusters that might be as important as the symptomatic cases in the spread of the disease. Group testing is a feasible and promising approach when the resources are scarce and when a relatively low prevalence regime is observed on the population. METHODS: We employed group testing with a sparse random pooling scheme and conventional group test decoding algorithms both for exact and inexact recovery. RESULTS: Our simulations showed that significant reduction in per case test numbers (or expansion in total test numbers preserving the number of actual tests conducted) for very sparse prevalence regimes is available. Currently proposed COVID-19 group testing schemes offer a gain up to 15X-20X scale-up. There is a good probability that the required scale up to achieve massive scale testing might be greater in certain scenarios. We investigated if further improvement is available, especially in sparse prevalence occurrence where outbreaks are needed to be avoided by population scans. CONCLUSION: Our simulations show that sparse random pooling can provide improved efficiency gains compared to conventional group testing or Reed-Solomon error correcting codes. Therefore, we propose that special designs for different scenarios could be available and it is possible to scale up testing capabilities significantly. url: https://doi.org/10.1186/s12874-020-01048-1 doi: 10.1186/s12874-020-01048-1 id: cord-010390-lc22hp3o author: Nenna, Raffaella title: Age Limit in Bronchiolitis Diagnosis: 6 or 12 Months? date: 2020-04-20 words: 2048.0 sentences: 128.0 pages: flesch: 51.0 cache: ./cache/cord-010390-lc22hp3o.txt txt: ./txt/cord-010390-lc22hp3o.txt summary: Bronchiolitis is a common cause of lower respiratory tract infection in infants and the major responsible factor of hospitalization under the age of one year, with the highest incidence occurring between December to March. The bivariate logistic regression designed to investigate the possible confounding factors (sex, clinical severity score, days of hospitalization and exposure to passive smoking, RSV, hBoV, and IV fluid) showed that the 6-12 months group had an odds ratio of hBoV detected at the NPA of 12.84 (95% CI 3.60-45.80) and the need of IV fluid of 0.45 (95% CI 0.20-0.99). According to our findings of a higher occurrence within the epidemic season and of the slightly higher frequency of recurrent wheezing at 36 months'' follow-up, infants > 6 months seems represent a different group of patients hospitalized for bronchiolitis, who are more predisposed to childhood asthma. • Bronchiolitis is a common cause of lower respiratory tract infection in infants and the major responsible factor of hospitalization under the age of one year. abstract: Aim: The most frequent cause of lower respiratory tract infection in infants is bronchiolitis. Up to now there is no agreement on the upper limit age of bronchiolitis. Our aim was to identify if there are clinical differences in infants hospitalized for bronchiolitis between 0–6 months and 6–12 months of age. A secondary aim was to establish whether there was differences in terms of recurrent wheezing at 12, 24, and 36 months of follow-up. Methods: We retrospectively analyzed clinical and virological records of 824 infants hospitalized for bronchiolitis during 11 consecutive epidemic seasons. From each infant at admission to the hospital nasopharyngeal washing was collected, clinical severity was assessed and clinical data were extracted from a structured questionnaire. At 12–24–36 months after discharge, parents were interviewed seeking information on recurrent wheezing. Results: A total of 773 infants (Group1) were ≤6 months of age, while 51 were >6 months (Group 2). No differences between family history for atopy and passive smoking exposure were observed between the two groups. Respiratory syncyzial virus was detected more frequently in Group 1 and human bocavirus in Group 2. The clinical severity score (p = 0.011) and the use of intravenous fluids (p = 0.0001) were higher in Group 1 with respect to Group 2 infants. At 36 months follow-up 163/106 (39.4%) Group 1 and 9/9 Group 2 infants experienced recurrent wheezing (p = 0.149). Conclusion: We demonstrated that 0-6 months old infants bronchiolitis differs from > 6 months bronchiolitis. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7184923/ doi: 10.3389/fped.2020.00144 id: cord-026493-z2hthkgy author: Newsom, Megan title: New and Emerging Systemic Treatments for Atopic Dermatitis date: 2020-06-09 words: 4136.0 sentences: 198.0 pages: flesch: 47.0 cache: ./cache/cord-026493-z2hthkgy.txt txt: ./txt/cord-026493-z2hthkgy.txt summary: In two phase III clinical trials, BREEZE-AD1 and BREEZE-AD2, by 16 weeks, a higher proportion of subjects in the treatment groups (1 mg, 2 mg, and 4 mg) achieved an IGA of 0 or 1, a ≥ 2-point improvement, and EASI-75 compared with the group receiving placebo (Table 1 ) [40] . In a phase IIb trial evaluating abrocitinib in moderate-to-severe AD by week 12, a higher proportion of subjects receiving 200 mg of drug and 100 mg of drug (43.8% and 29.6%) had an IGA of 0 or 1 plus a ≥ 2-point improvement from baseline compared with those receiving placebo (5.8%; p < 0.001 and p < 0.001, respectively) [41] . Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 Randomized Clinical Trial Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b Randomized Clinical Trial abstract: Atopic dermatitis (AD) is a prevalent inflammatory skin condition that, depending on its severity, can cause enormous morbidity. Corticosteroids and systemic immunosuppression, traditionally standard of care for difficult-to-treat disease, have many undesirable side effects. The desire for targeted treatments along with an improved understanding of the pathophysiology of AD has spurred the development of novel treatments. In this article, we review promising new treatments and discuss how their targets—IL-13, IL-31, OX40 (CD134), and the Janus kinase family of proteins—participate in the pathogenesis of AD. We review the published phase II and III data for dupilumab, tralokinumab, lebrikizumab, nemolizumab, anti-OX40 antibody, baricitinib, abrocitinib, and upadacitinib. The introduction of new agents may offer new options, but it remains to be seen how narrow-acting agents, like single interleukin inhibitors, will compare in safety and efficacy to broad-acting agents such as JAK inhibitors. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281689/ doi: 10.1007/s40265-020-01335-7 id: cord-006864-t5qsjyfi author: Norris, S. title: National scientific medical meeting 1995 abstracts: Oral presentations date: 1995 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103225/ doi: 10.1007/bf02967283 id: cord-003024-17f1evh3 author: Nunes, Márcio Roberto Teixeira title: Revalidation and genetic characterization of new members of Group C (Orthobunyavirus genus, Peribunyaviridae family) isolated in the Americas date: 2018-05-24 words: 3449.0 sentences: 166.0 pages: flesch: 47.0 cache: ./cache/cord-003024-17f1evh3.txt txt: ./txt/cord-003024-17f1evh3.txt summary: Maximum likelihood (ML) phylogenetic trees were constructed using nucleotide and amino acids sequences of viruses reported in our study and additional sequences of members of Group C viruses with complete coding sequences (S, M, and L) available in the GenBank database (http://www.ncbi.nlm.nih.gov/) until 10 th of April of 2018. Our results showed that the complete SRNA segments of Group C viruses ranged from 1,003 to 1,111 nucleotides (nt) and presents the open reading frame (ORF) of the nucleocapsid (N) protein, with a conserved size of 235 amino acids (aa) and 26.72 to 27.03 kDa for all viruses (Fig 1) . To better understand the genetic relationships among group C viruses, we conducted the ML trees based on the complete coding sequences in nucleotide and amino acids level for all segments (Fig 3 and S1 Fig) . abstract: Group C serogroup includes members of the Orthobunyavirus genus (family Peribunyaviridae) and comprises 15 arboviruses that can be associated with febrile illness in humans. Although previous studies described the genome characterization of Group C orthobunyavirus, there is a gap in genomic information about the other viruses in this group. Therefore, in this study, complete genomes of members of Group C serogroup were sequenced or re-sequenced and used for genetic characterization, as well as to understand their phylogenetic and evolutionary aspects. Thus, our study reported the genomes of three new members in Group C virus (Apeu strain BeAn848, Itaqui strain BeAn12797 and Nepuyo strain BeAn10709), as well as re-sequencing of original strains of five members: Caraparu (strain BeAn3994), Madrid (strain BT4075), Murucutu (strain BeAn974), Oriboca (strain BeAn17), and Marituba (strain BeAn15). These viruses presented a typical genomic organization related to members of the Orthobunyavirus genus. Interestingly, all viruses of this serogroup showed an open reading frame (ORF) that encodes the putative nonstructural NSs protein that precedes the nucleoprotein ORF, an unprecedented fact in Group C virus. Also, we confirmed the presence of natural reassortment events. This study expands the genomic information of Group C viruses, as well as revalidates the genomic organization of viruses that were previously reported. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5967719/ doi: 10.1371/journal.pone.0197294 id: cord-017067-19eawrjt author: Ogbondah, Chris Wolumati title: Terrorists and Social Media Messages: A Critical Analysis of Boko Haram’s Messages and Messaging Techniques date: 2017-10-24 words: 11733.0 sentences: 617.0 pages: flesch: 59.0 cache: ./cache/cord-017067-19eawrjt.txt txt: ./txt/cord-017067-19eawrjt.txt summary: An examination of Boko Haram''s attempts to win the battle for the hearts and minds of Nigerians through a deliberate use of video propaganda as well as a critical analysis of the statements by its leader, Shekau, will provide governmental and institutional policymakers in Nigeria a deeper understanding of the nature and operations of Boko Haram. 1) This chapter is also significant because by analyzing the speeches made by Boko Haram''s leader in the social media and in particular YouTube videos and major acts of terrorism carried out by the group, Nigerian and West African leaders and leaders elsewhere in the world might further understand how the minds of the leaders of terrorist organizations work. In one thirty-six-minute YouTube video that the authors accessed at https://www.youtube.com/watch?v=MgdKblgzggQ, Shekau boasts that the avalanche of weapons that Boko Haram captured from fleeing Nigerian soldiers including those seized during its attack on Baga in Borno State would be enough for the Jihadists to successfully prosecute the entire war. abstract: Post-colonial Nigeria has been plagued with violent conflicts. A bloody civil war in which an estimated 1 million people were killed ravaged the country from 1967 to 1970. Interethnic and intra-communal conflicts have also shaken the foundations of the nation since 1960 when colonial rule ended. Other violent conflicts that have plagued the country are religious conflicts in Kano, Bauchi, Kaduna, Kafanchan, Zaria, Jos, Maiduguri, and many other places. Blood-letting in the name of religion in these and other places in Nigeria has left thousands dead and wounded. Destruction of property in the course of religious violence in Nigeria has also wreaked economic calamity on the country. For instance, wanton destruction of property during the Maitatsene religious uprising in Kano from 1980 to 1985 resulted in the loss of lives and of millions of dollars. Clashes between members of the militant Shi’ite religious sect and the Nigerian army in 2016 led to the demolition of an entire neighborhood in Zaria city Nigeria’s latest bout of violence emanates from a deadly terrorist group, Boko Haram. Since 2009, it has killed over 20,000 people, displaced more than one million people, and contributed to the devastation of Nigeria’s northeast region. Initially, Boko Haram could not be contained by Nigerian security forces. It captured and held on to 14 local government districts and it constantly churned out online propaganda about its invisibility and its certainty that it would impose a radical Islamic government over the entire country. This chapter provides a critical analysis of Boko Haram’s propaganda. It examines the group’s core messages and the stylistic techniques used in delivering them. The chapter notes that Boko Haram deliberately used crude, unvanished imagery to reinforce the brutality of its actions in suicide bombings, drive-by shootings, and direct attacks against military barracks, markets, mosques, and churches. We contend that the effectiveness of Boko Haram’s propaganda began to decline as it suffered military defeats by Nigerian forces. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121539/ doi: 10.1007/978-3-319-70443-2_18 id: cord-030277-x9zvx3fp author: Ohta, Yoshinori title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial date: 2020-08-10 words: 4064.0 sentences: 215.0 pages: flesch: 52.0 cache: ./cache/cord-030277-x9zvx3fp.txt txt: ./txt/cord-030277-x9zvx3fp.txt summary: title: Effect of dexmedetomidine on inflammation in patients with sepsis requiring mechanical ventilation: a sub-analysis of a multicenter randomized clinical trial We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitonin, and thus on inflammation, in patients with sepsis enrolled in a randomized clinical trial. METHODS: The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. We analyzed data derived from a randomized clinical trial and found that the administration of dexmedetomidine to patients with sepsis on ventilators improved CRP and PCT levels during the first 14 days in the ICU. In the present study, the use of dexmedetomidine for sedation reduced both CRP and PCT levels in patients with sepsis. Effect of dexmedetomidine on mortality and ventilator-free days in patients requiring mechanical ventilation with sepsis: a randomized clinical trial abstract: BACKGROUND: Administration of dexmedetomidine has been reported to improve inflammatory response in animals. We explored the effects of administering dexmedetomidine on the levels of C-reactive protein (CRP) and procalcitonin, and thus on inflammation, in patients with sepsis enrolled in a randomized clinical trial. METHODS: The DESIRE trial was a multicenter randomized clinical trial in which adult patients with sepsis were sedated with (DEX group) or without (non-DEX group) dexmedetomidine while on mechanical ventilators. As a prespecified sub-analysis, we compared CRP and procalcitonin levels during the first 14 days of treatment between the two groups. The 14-day mortality rate, albumin level, and the number of patients with disseminated intravascular coagulation (DIC) were also assessed. We used generalized linear models to estimate the differences in these outcomes between groups. We also used the Kaplan-Meier method to estimate the 14-day mortality rate and the log-rank test to assess between-group differences. RESULTS: Our study comprised 201 patients: 100 in the DEX group and 101 in the non-DEX group. CRP and procalcitonin levels were lower in the DEX vs. non-DEX group during the 14-day treatment period [CRP—range, 5.6–20.3 vs. 8.3–21.1 mg/dL (P = 0.03); procalcitonin—range, 1.2–37.4 vs. 1.7–52.9 ng/mL (P = 0.04)]. Albumin levels were higher in the DEX group (range, 2.3–2.6 g/dL) than in the non-DEX group (range, 2.1–2.7 g/dL; P = 0.01). The percentage of patients with DIC did not significantly differ between the groups (range, 21–59% and 17–56% for the DEX and non-DEX groups, respectively; P = 0.49). The 14-day mortality rates in the DEX and non-DEX groups were 13 and 21%, respectively (P = 0.16). CONCLUSION: Sedation using dexmedetomidine reduced inflammation in patients with sepsis requiring mechanical ventilation. TRIAL REGISTRATION: ClinicalTrials.gov, NCT01760967. Registered on 4 January 2013. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416813/ doi: 10.1186/s13054-020-03207-8 id: cord-329468-vjsurl60 author: Okino, Cintia Hiromi title: Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profiles date: 2017-02-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Avian infectious bronchitis virus (IBV) primarily replicates in epithelial cells of the upper respiratory tract of chickens, inducing both morphological and immune modulatory changes. However, the association between the local immune responses induced by IBV and the mechanisms of pathogenesis has not yet been completely elucidated. This study compared the expression profile of genes related to immune responses in tracheal samples after challenge with two Brazilian field isolates (A and B) of IBV from the same genotype, associating these responses with viral replication and with pathological changes in trachea and kidney. We detected a suppressive effect on the early activation of TLR7 pathway, followed by lower expression levels of inflammatory related genes induced by challenge with the IBV B isolate when compared to the challenge with to the IBV A isolate. Cell-mediated immune (CMI) related genes presented also lower levels of expression in tracheal samples from birds challenged with B isolate at 1dpi. Increased viral load and a higher percentage of birds with relevant lesions were observed in both tracheal and renal samples from chickens exposed to challenge with IBV B isolate. This differential pattern of early immune responses developed after challenge with IBV B isolate, related to the downregulation of TLR7, leading to insufficient pro-inflammatory response and lower CMI responses, seem to have an association with a most severe renal lesion and an enhanced capability of replication of this isolate in chicken. url: https://www.ncbi.nlm.nih.gov/pubmed/28199419/ doi: 10.1371/journal.pone.0172275 id: cord-021419-nypnib0h author: Olsufyeva, Evgenia N. title: Main trends in the design of semi-synthetic antibiotics of a new generation date: 2020-03-17 words: 16144.0 sentences: 923.0 pages: flesch: 45.0 cache: ./cache/cord-021419-nypnib0h.txt txt: ./txt/cord-021419-nypnib0h.txt summary: In this review, the following classes of compounds are considered as scaffolds for the synthesis of new antibiotics: polycyclic glycopeptides of the vancomycin ± teicoplanin group, classical macrolides, macrolides of the amphotericin B ± oligomycin group, anthracyclines, aureolic acid derivatives, heliomycin, synthetic benzoxaboroles and some other antibiotics. 42 Antibacterial activity of derivatives 52 ± 55 modified at the C(11)7OH group of the aglycone was evaluated compared to the starting antibiotics vancomycin (1) and azithromycin (30) on a panel of Gram-positive and Gramnegative bacterial strains (8 and 3 strains, respectively). In order to improve antifungal properties, cytotoxic and therapeutic characteristics and to study the mechanisms of action, series of new semi-synthetic derivatives based on AmB (63a) and bioengineered analogues S44HP (64a), BSG005 (65a), BSG022 (66a), BSG019 (67), BSG003 (68a) and BSG018 (69) were synthesized (in collaboration with the company BIOSERGEN, Norway) (Scheme 17). abstract: This review summarizes main advances achieved by Russian researchers in the synthesis and characterization of semi-synthetic antibiotics of a new generation in the period from 2004 to 2019. The following classes of compounds are considered as the basis for modification: polycyclic antibacterial glycopeptides of the vancomycin group, classical macrolides, antifungal polyene macrolides, the antitumour antibiotic olivomycin A, antitumour anthracyclines and broad-spectrum antibiotics, in particular, oligomycin A, heliomycin and some other. Main trends in the design of modern anti-infective and antitumour agents over this period are considered in relation to original natural antibiotics, which have been independently discovered by Russian researchers. It is shown that a new type of hybrid structures can, in principle, be synthesized based on glycopeptides, macrolides and other antibiotics, including heterodimers containing a new benzoxaborole pharmacophore. The review addresses the influence of the length of the spacer between two antibiotic molecules on the biological activity of hybrid structures. A combination of genetic engineering techniques and methods of organic synthesis is shown to be useful for the design of new potent antifungal antibiotics based on polyenes of the amphotericin B group. Many new semi-synthetic analogues exhibit important biological properties, such as a broad spectrum of activity and low toxicity. Emphasis is given to certain aspects related to investigation of a broad range of biological activity and mechanisms of action of new derivatives. The bibliography includes 101 references. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7149660/ doi: 10.1070/rcr4892 id: cord-289865-36ai2xgy author: Paddon, Laura Isobel title: Therapeutic or detrimental mobilities? Walking groups for older adults date: 2020-04-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The health benefits of walking through greenspace have earned widespread academic attention in recent years and have been termed ‘therapeutic mobilities’. As a result, walking groups are actively encouraged by health professionals as a way to promote ‘healthy ageing’. This paper examines whether the promotion of community-led walking groups relies upon overly optimistic understandings that portray walking in greenspace as an inherently therapeutic practice. Accordingly, this paper introduces the concept of ‘detrimental mobilities’ to explore how the shared movement promoted via walking groups may not always be inherently therapeutic and may have some detrimental impacts on the individuals who take part in these activities. Drawing on findings from in-depth walking interviews with older members of the ‘Walking for Health’ scheme in Southampton, England, this paper examines how mobilities have the potential to disable, as much as they enable, health and wellbeing. url: https://www.sciencedirect.com/science/article/pii/S1353829219310585?v=s5 doi: 10.1016/j.healthplace.2020.102346 id: cord-284804-6i5zbmm1 author: Pan, Feng title: Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study date: 2020-05-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Rationale: Up to date, the exploration of clinical features in severe COVID-19 patients were mostly from the same center in Wuhan, China. The clinical data in other centers is limited. This study aims to explore the feasible parameters which could be used in clinical practice to predict the prognosis in hospitalized patients with severe coronavirus disease-19 (COVID-19). Methods: In this case-control study, patients with severe COVID-19 in this newly established isolation center on admission between 27 January 2020 to 19 March 2020 were divided to discharge group and death event group. Clinical information was collected and analyzed for the following objectives: 1. Comparisons of basic characteristics between two groups; 2. Risk factors for death on admission using logistic regression; 3. Dynamic changes of radiographic and laboratory parameters between two groups in the course. Results: 124 patients with severe COVID-19 on admission were included and divided into discharge group (n=35) and death event group (n=89). Sex, SpO2, breath rate, diastolic pressure, neutrophil, lymphocyte, C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), and D-dimer were significantly correlated with death events identified using bivariate logistic regression. Further multivariate logistic regression demonstrated a significant model fitting with C-index of 0.845 (p<0.001), in which SpO2≤89%, lymphocyte≤0.64×10(9)/L, CRP>77.35mg/L, PCT>0.20μg/L, and LDH>481U/L were the independent risk factors with the ORs of 2.959, 4.015, 2.852, 3.554, and 3.185, respectively (p<0.04). In the course, persistently lower lymphocyte with higher levels of CRP, PCT, IL-6, neutrophil, LDH, D-dimer, cardiac troponin I (cTnI), brain natriuretic peptide (BNP), and increased CD4+/CD8+ T-lymphocyte ratio and were observed in death events group, while these parameters stayed stable or improved in discharge group. Conclusions: On admission, the levels of SpO2, lymphocyte, CRP, PCT, and LDH could predict the prognosis of severe COVID-19 patients. Systematic inflammation with induced cardiac dysfunction was likely a primary reason for death events in severe COVID-19 except for acute respiratory distress syndrome. url: https://www.ncbi.nlm.nih.gov/pubmed/32547323/ doi: 10.7150/ijms.46614 id: cord-003913-jr9hj0bs author: Park, Hyeong-Jun title: Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant date: 2019-09-07 words: 7537.0 sentences: 429.0 pages: flesch: 53.0 cache: ./cache/cord-003913-jr9hj0bs.txt txt: ./txt/cord-003913-jr9hj0bs.txt summary: Furthermore, poly I:C induced higher pro-inflammatory cytokines than those of ssRNA nanostructure adjuvant in RAW 264.7 cells, which are a mouse macrophage cell line ( Figure S3 , detailed in supplementary methods), indicating poly I:C may stimulate a stronger inflammation response compared to that of the ssRNA nano-structure adjuvant. Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ). Not only the liver, which is a typical organ studied to assess toxicity, but also the lungs, kidneys, injection sites, and immune-related organs (spleen and thymus) were stained with H + E to observe local and systemic toxicity, including cellular damage and inflammatory cell infiltration, associated with the ssRNA nano-structure adjuvant (Figure 4 ). abstract: Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene expression and pathways. Although some adjuvants have been approved for commercial use in human vaccines (e.g., Alum, MF59, and AS03), they might elicit adverse side effects, such as autoimmune diseases. Recently, we developed a novel single-stranded RNA (ssRNA) nano-structure adjuvant, which can stimulate both Th1 and Th2 responses. In this study, we evaluated the safety and toxicological profiles of this ssRNA nano-structure adjuvant in vitro and in vivo. Mice were intramuscularly immunized with the ssRNA nano-structure adjuvant three times, once every 2 weeks. The results indicate no significant differences in hematological and serum biochemistry parameters between the ssRNA-treated groups and the control group. From a histopathological perspective, no evidence of tissue damage was found in any group. The levels of IgE and anti-nuclear antibodies, which are markers of autoimmune disease, were not different between the ssRNA-treated groups and the control group. The findings of this study suggest that the ssRNA nano-structure can be used as a safe adjuvant to increase vaccine efficacies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781302/ doi: 10.3390/pharmaceutics11090464 id: cord-274396-l611eisi author: Park, Su-Jin title: Antiviral Efficacies of FDA-Approved Drugs against SARS-CoV-2 Infection in Ferrets date: 2020-05-22 words: 4355.0 sentences: 208.0 pages: flesch: 46.0 cache: ./cache/cord-274396-l611eisi.txt txt: ./txt/cord-274396-l611eisi.txt summary: While the lopinavir-ritonavir-, hydroxychloroquine sulfate-, or emtricitabine-tenofovir-treated group exhibited lower overall clinical scores than the phosphate-buffered saline (PBS)-treated control group, the virus titers in nasal washes, stool specimens, and respiratory tissues were similar between all three antiviral-candidate-treated groups and the PBS-treated control group. Compared to the PBS-treated control group, azathioprine-immunosuppressed ferrets exhibited a longer period of clinical illness, higher virus titers in nasal turbinate, delayed virus clearance, and significantly lower serum neutralization (SN) antibody titers. In order to determine the antiviral efficacies of lopinavir-ritonavir, hydroxychloroquine (HCQ) sulfate, or emtricitabine-tenofovir for treatment of SARS-CoV-2 infection, SARS-CoV-2 antibody-free ferrets (10/group) were inoculated with 10 5.8 50% tissue culture infective doses (TCID 50 )/ml of an NMC-nCoV02 strain through the intranasal (i.n.) route ( Fig. 1 ). Therefore, although clinical symptoms were attenuated in ferret groups treated with antiviral candidates, we also evaluated virus titers in respiratory and gastrointestinal tracts using nasal washes and stool samples, respectively, from SARS-CoV-2-infected ferrets. abstract: Due to the urgent need of a therapeutic treatment for coronavirus (CoV) disease 2019 (COVID-19) patients, a number of FDA-approved/repurposed drugs have been suggested as antiviral candidates at clinics, without sufficient information. Furthermore, there have been extensive debates over antiviral candidates for their effectiveness and safety against severe acute respiratory syndrome CoV 2 (SARS-CoV-2), suggesting that rapid preclinical animal studies are required to identify potential antiviral candidates for human trials. To this end, the antiviral efficacies of lopinavir-ritonavir, hydroxychloroquine sulfate, and emtricitabine-tenofovir for SARS-CoV-2 infection were assessed in the ferret infection model. While the lopinavir-ritonavir-, hydroxychloroquine sulfate-, or emtricitabine-tenofovir-treated group exhibited lower overall clinical scores than the phosphate-buffered saline (PBS)-treated control group, the virus titers in nasal washes, stool specimens, and respiratory tissues were similar between all three antiviral-candidate-treated groups and the PBS-treated control group. Only the emtricitabine-tenofovir-treated group showed lower virus titers in nasal washes at 8 days postinfection (dpi) than the PBS-treated control group. To further explore the effect of immune suppression on viral infection and clinical outcome, ferrets were treated with azathioprine, an immunosuppressive drug. Compared to the PBS-treated control group, azathioprine-immunosuppressed ferrets exhibited a longer period of clinical illness, higher virus titers in nasal turbinate, delayed virus clearance, and significantly lower serum neutralization (SN) antibody titers. Taken together, all antiviral drugs tested marginally reduced the overall clinical scores of infected ferrets but did not significantly affect in vivo virus titers. Despite the potential discrepancy of drug efficacies between animals and humans, these preclinical ferret data should be highly informative to future therapeutic treatment of COVID-19 patients. url: https://www.ncbi.nlm.nih.gov/pubmed/32444382/ doi: 10.1128/mbio.01114-20 id: cord-288528-f6oz6zyz author: Pastakia, Sonak D. title: Preserving 2 decades of healthcare gains for Africa in the coronavirus disease 2019 era date: 2020-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: As coronavirus disease 2019 (Covid-19) restrictions upend the community bonds that have enabled African communities to thrive in the face of numerous challenges, it is vital that the gains made in community-based healthcare are preserved by adapting our approaches. Instead of reversing the many gains made through locally driven development partnerships with international funding agencies for other viral diseases like HIV, we must use this opportunity to adapt the many lessons learned to address the burden of Covid-19. Programs like the Academic Model Providing Access to Healthcare are currently leveraging widely available technologies in Africa to prevent patients from experiencing significant interruptions in care as the healthcare system adjusts to the challenges presented by Covid-19. These approaches are designed to preserve social contact while incorporating physical distancing. The gains and successes made through approaches like group-based medical care must not only continue but can help expand upon the extraordinary success of programs like President's Emergency Plan for AIDS Relief. url: https://www.ncbi.nlm.nih.gov/pubmed/32701586/ doi: 10.1097/qad.0000000000002605 id: cord-282879-28nhr1hv author: Patel, Samir N. title: The impact of physician face mask use on endophthalmitis after intravitreal anti-vascular endothelial growth factor injections date: 2020-09-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: PURPOSE: To evaluate the effect of physician face mask use on rates and outcomes of post-injection endophthalmitis. DESIGN: Retrospective, comparative cohort study METHODS: . SETTING: Single-center STUDY POPULATION: Eyes receiving intravitreal anti-vascular endothelial growth factor injections from 7/1/2013 to 9/1/2019. INTERVENTION: Cases were divided into “face mask group” if face masks were worn by the physician during intravitreal injections or “no talking group” if no face mask was worn but a no talking policy was observed during intravitreal injections. MAIN OUTCOME MEASURES: Rate of endophthalmitis, visual acuity, and microbial spectrum. RESULTS: Of 483,622 intravitreal injections administered, 168 out of 453,460 (0.0371%) cases of endophthalmitis occurred in the “no talking” group, and 9 out of 30,162 (0.0298%) cases occurred in the face mask group (odds ratio, 0.81; 95%CI, 0.41–1.57; p=0.527). Sixteen cases of oral flora-associated endophthalmitis were found in the “no talking” group (1 in 28,341 injections) compared to none in the face mask group (p=0.302). Mean logMAR visual acuity at presentation in cases that developed culture-positive endophthalmitis was significantly worse in the “no talking” group compared to the face mask group (17.1 lines lost from baseline acuity vs 13.4 lines lost; p=0.031), though no difference was observed at six months following treatment (p=0.479). CONCLUSION: Physician face mask use did not influence the risk of post-injection endophthalmitis compared to a no talking policy. However, no cases of oral flora-associated endophthalmitis occurred in the face mask group. Future studies are warranted to assess the role of face mask use to reduce endophthalmitis risk, particularly due to oral flora. url: https://www.sciencedirect.com/science/article/pii/S0002939420304384?v=s5 doi: 10.1016/j.ajo.2020.08.013 id: cord-339705-x8l3zgfd author: Patil, Vijaykumar title: An association between fingerprint patterns with blood group and lifestyle based diseases: a review date: 2020-08-18 words: 19191.0 sentences: 980.0 pages: flesch: 52.0 cache: ./cache/cord-339705-x8l3zgfd.txt txt: ./txt/cord-339705-x8l3zgfd.txt summary: Due to the immense potential of fingerprints as an effective method of identification, the present research paper tries to investigate the problem of blood group identification and analysis of diseases those arises with aging like hypertension, type 2-diabetes and arthritis from a fingerprint by analyzing their patterns correlation with blood group and age of an individual. The fingerprint having basic four categories which are loop, whorl, arch and composites but also there are more than 100 interleaved ridge and valleys which explore unique characteristics of an individual which will help to design Deep Neural Network or Convolutional Neural Network (CNN) which predict blood group and common clinical diseases like hypertension, type 2-diabetes and arthritis. From the present investigation, the accompanying ends are drawn: (1) Loops are the most regularly discovered fingerprint pattern and arches are minimal normal in the two guys and females and furthermore in "ABO" blood groups. abstract: In the current era of the digital world, the hash of any digital means considered as a footprint or fingerprint of any digital term but from the ancient era, human fingerprint considered as the most trustworthy criteria for identification and it also cannot be changed with time even up to the death of an individual. In the court of law, fingerprint-proof is undeniably the most dependable and acceptable evidence to date. Fingerprint designs are exclusive in each human and the chance of two individuals having identical fingerprints is an exceptional case about one in sixty-four thousand million also the fingerprint minutiae patterns of the undistinguishable twins are different, and the ridge pattern of each fingertip remain unchanged from birth to till death. Fingerprints can be divided into basic four categories i.e. Loop, whorl, arch, and composites, nevertheless, there are more than 100 interleaved ridge and valleys physiognomies, called Galton’s details, in a single rolled fingerprint. Due to the immense potential of fingerprints as an effective method of identification, the present research paper tries to investigate the problem of blood group identification and analysis of diseases those arises with aging like hypertension, type 2-diabetes and arthritis from a fingerprint by analyzing their patterns correlation with blood group and age of an individual. The work has been driven by studies of anthropometry, biometric trademark, and pattern recognition proposing that it is possible to predict blood group using fingerprint map reading. Dermatoglyphics as a diagnostic aid used from ancient eras and now it is well established in number of diseases which have strong hereditary basis and is employed as a method for screening for abnormal anomalies. Apart from its use in predicting the diagnosis of disease; dermatoglyphics is also used in forensic medicine in individual identification, physical anthropology, human genetics and medicine. However, the Machine and Deep Learning techniques, if used for fingerprint minutiae patterns to be trained by Neural Network for blood group prediction and classification of common clinical diseases arises with aging based on lifestyle would be an unusual research work. url: https://doi.org/10.1007/s10462-020-09891-w doi: 10.1007/s10462-020-09891-w id: cord-337644-aobdzwpx author: Pianta, L. title: Acetic acid disinfection as a potential adjunctive therapy for non-severe COVID-19 date: 2020-05-24 words: 1742.0 sentences: 94.0 pages: flesch: 53.0 cache: ./cache/cord-337644-aobdzwpx.txt txt: ./txt/cord-337644-aobdzwpx.txt summary: CONCLUSIONS: Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation. Therefore, considering these antiviral properties and that the upper airways are the main site of SARS-CoV-2 entry and replication, we have explored the use of this historical therapy in early-stage cases of COVID-19 by evaluating patients who were administered a disinfecting formulation of acetic acid as an intranasal aerosol. Patients treated with off-label hydroxychloroquine and lopinavir/ritonavir, the standard treatment prescribed at that time, were included in group 1, whereas group 2 was composed of patients treated with hydroxychloroquine only, combined with acetic acid nasal disinfectant at a 0.34% concentration. Acetic acid disinfection could not only improve the clinical course of COVID-19, but also reduce viral load in the airway and in the droplets exhaled by infected individuals. abstract: PURPOSE: SARS-CoV-2 is a new pandemic influenza caused by a coronavirus which main route of transmission is through exhaled droplets that primarily infect the nose and the nasopharynx. The aim of this paper is to evaluate the effect of acetic acid, the active component of vinegar, as a potential disinfectant agent for upper airways. METHODS: Twenty-nine patients were enrolled and divided into two groups: group 1 (14 patients) was composed of patients treated with off-label hydroxychloroquine and lopinavir/ritonavir, whereas group 2 (15 patients) was composed of patients treated with hydroxychloroquine only, combined with the inhalation of acetic acid disinfectant at a 0.34% concentration. A questionnaire-based evaluation of symptoms was performed after 15 days in both groups. RESULTS: It appears that the number of patients treated with acetic acid (group 2) that experienced improvement in individual symptoms was double that of the other group of patients (group 1), although numbers are too small for robust statistical analysis. CONCLUSIONS: Considering its potential benefits and high availability, acetic acid disinfection appears to be a promising adjunctive therapy in cases of non-severe COVID-19 and deserves further investigation. url: https://doi.org/10.1007/s00405-020-06067-8 doi: 10.1007/s00405-020-06067-8 id: cord-329669-z3t7plvh author: Poulton, Kay title: A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients date: 2020-07-05 words: 2270.0 sentences: 124.0 pages: flesch: 50.0 cache: ./cache/cord-329669-z3t7plvh.txt txt: ./txt/cord-329669-z3t7plvh.txt summary: HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. This study investigated HLA profiles of patients admitted with PCR-confirmed SARS-CoV-2 infection to identify any potential HLA bias which might indicate an impaired capacity to mount an effective immune response to the infection. All patients included in the study had previously been HLA typed to support transplantation and required hospital treatment for COVID-19 disease, indicating that their symptoms were severe, requiring clinical support or intervention. Statistical analysis was performed using MedCalc v19.3 (MedCalc Software) to compare frequencies of allele group carriage between the patient and control populations using Fisher''s exact test. abstract: We analysed data from 80 patients who tested positive for SARS‐CoV‐2 RNA who had previously been HLA typed to support transplantation. Data were combined from two adjacent centres in Manchester and Leeds to achieve a sufficient number for early analysis. HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. We report a significant HLA association with HLA‐ DQB1*06 (53% vs. 36%; p < .012; OR 1.96; 95% CI 1.94–3.22) and infection. A bias towards an increased representation of HLA‐A*26, HLA‐DRB1*15, HLA‐DRB1*10 and DRB1*11 was also noted but these were either only significant using the UK donor controls, or did not remain significant after correction for multiple tests. Likewise, HLA‐A*02, HLA‐B*44 and HLA‐C*05 may exert a protective effect, but these associations did not remain significant after correction for multiple tests. This is relevant information for the clinical management of patients in the setting of the current SARS‐CoV‐2 pandemic and potentially in risk‐assessing staff interactions with infected patients. url: https://doi.org/10.1111/iji.12505 doi: 10.1111/iji.12505 id: cord-262716-hea84shy author: Pourali, Fatemeh title: Relationship between blood group and risk of infection and death in COVID-19: a live meta-analysis date: 2020-08-11 words: 3858.0 sentences: 208.0 pages: flesch: 57.0 cache: ./cache/cord-262716-hea84shy.txt txt: ./txt/cord-262716-hea84shy.txt summary: The reported results were controversial, so the objective of the present study is to assess the relationship between different blood groups and the onset and mortality of COVID-19 infection using meta-analysis method. Note that there are limited primary evidence regarding the association between blood groups and COVID19 infection, upcoming relevant studies will be added to the results of the present meta-analysis. Of the evidence included in this meta-analysis, five studies had reported the frequency of blood group AB among COVID-19 infected people varied between 3.08% and 13.68%. Combining the results of this two evidence, applying random effect model (I-square=0%, Q=0.41, P=0.522), the odd ratio for death among COVID-19 infected people having blood group A was estimated as 1.12 (95% CI: 0.87, 1.45). Meta-analysis of studies showed no significant association between mortality and different blood groups in COVID-19 patients. abstract: Abstract Introduction The relationship between ABO blood group and the incidence of COVID-19 infection and death has been investigated in several studies. The reported results were controversial, so the objective of the present study is to assess the relationship between different blood groups and the onset and mortality of COVID-19 infection using meta-analysis method. Methods We searched the databases using appropriate MeSH terms. We screened articles on the basis of titles, abstracts, and full texts, and the articles that met the inclusion criteria were selected. Quality assessment was done with the Newcastle-Ottawa Scale checklist. The estimated frequency of COVID-19 infection and death in terms of ABO blood group and the overall estimate of the odd ratio between blood group with COVID-19 infection and death was done with 95% confidence interval. Results The pooled frequency of blood groups A, B, O, and AB among COVID-19 infected individuals was estimated as 36.22%, 24.99%, 29.67%, and 9.29% respectively. The frequency of blood groups A, B, O, and AB among the dead cases due to COVID-19 infection was estimated as 40%, 23%, 29%, and 8% respectively. The odd ratio of COVID-19 infection for blood group A versus the other blood groups was estimated 1.16 (CI 95%: 1.02-1.33). The corresponding figures for blood groups O and AB versus other blood groups were estimated as 0.73 (CI 95%: 0.60-0.88) and 1.25(CI 95%: 0.84-1.86) respectively. Conclusion This meta-analysis showed that individuals with blood group A are at higher risk for COVID-19 infection while those with blood group O are at lower risk. Although the odds ratio of death for AB blood group was non-significant, it was considerable. url: https://www.sciencedirect.com/science/article/pii/S2052297520300950?v=s5 doi: 10.1016/j.nmni.2020.100743 id: cord-276288-upv2o8f6 author: Prior, Sarah Jane title: Person-centred data collection methods to embed the authentic voice of people who experience health challenges date: 2020-07-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32699082/ doi: 10.1136/bmjoq-2020-000912 id: cord-349720-2lxab3u2 author: Qin, Ling title: Phytomolecule icaritin incorporated PLGA/TCP scaffold for steroid-associated osteonecrosis: Proof-of-concept for prevention of hip joint collapse in bipedal emus and mechanistic study in quadrupedal rabbits date: 2015-05-15 words: 9960.0 sentences: 525.0 pages: flesch: 52.0 cache: ./cache/cord-349720-2lxab3u2.txt txt: ./txt/cord-349720-2lxab3u2.txt summary: Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after surgical core-decompression (CD) to prevent femoral head collapse in a bipedal SAON animal model using emu (a large flightless bird). In conclusion, both efficacy and mechanistic studies show the potential of a bioactive composite porous P/T scaffold incorporating icaritin to enhance bone defect repair after surgical CD and prevent femoral head collapse in a bipedal SAON emu model. Applying a recently established bipedal emu SAON model with femoral head collapse similar to that typically observed in patients [23] , this study was designed to test the ability of our unique PLGA/ TCP/icaritin scaffold to enhance bone defect repair within a bone tunnel after surgical CD and to prevent femoral head collapse. abstract: Steroid-associated osteonecrosis (SAON) may lead to joint collapse and subsequent joint replacement. Poly lactic-co-glycolic acid/tricalcium phosphate (P/T) scaffold providing sustained release of icaritin (a metabolite of Epimedium-derived flavonoids) was investigated as a bone defect filler after surgical core-decompression (CD) to prevent femoral head collapse in a bipedal SAON animal model using emu (a large flightless bird). The underlying mechanism on SAON was evaluated using a well-established quadrupedal rabbit model. Fifteen emus were established with SAON, and CD was performed along the femoral neck for the efficacy study. In this CD bone defect, a P/T scaffold with icaritin (P/T/I group) or without icaritin (P/T group) was implanted while no scaffold implantation was used as a control. For the mechanistic study in rabbits, the effects of icaritin and composite scaffolds on bone mesenchymal stem cells (BMSCs) recruitment, osteogenesis, and anti-adipogenesis were evaluated. Our efficacy study showed that P/T/I group had the significantly lowest incidence of femoral head collapse, better preserved cartilage and mechanical properties supported by more new bone formation within the bone tunnel. For the mechanistic study, our in vitro tests suggested that icaritin enhanced the expression of osteogenesis related genes COL1α, osteocalcin, RUNX2, and BMP-2 while inhibited adipogenesis related genes C/EBP-ß, PPAR-γ, and aP2 of rabbit BMSCs. Both P/T and P/T/I scaffolds were demonstrated to recruit BMSCs both in vitro and in vivo but a higher expression of migration related gene VCAM1 was only found in P/T/I group in vitro. In conclusion, both efficacy and mechanistic studies show the potential of a bioactive composite porous P/T scaffold incorporating icaritin to enhance bone defect repair after surgical CD and prevent femoral head collapse in a bipedal SAON emu model. url: https://www.sciencedirect.com/science/article/pii/S0142961215004135 doi: 10.1016/j.biomaterials.2015.04.038 id: cord-001809-azb7nie3 author: Qvarnstrom, Yvonne title: Characterization of a New Pathogenic Acanthamoeba Species, A. byersi n. sp., Isolated from a Human with Fatal Amoebic Encephalitis date: 2013-07-24 words: 4509.0 sentences: 259.0 pages: flesch: 57.0 cache: ./cache/cord-001809-azb7nie3.txt txt: ./txt/cord-001809-azb7nie3.txt summary: DNA sequence analysis, secondary structure prediction, and phylogenetic analysis of the 18S rRNA gene confirmed that this new strain belonged to Group 1, but that it was distinct from the other sequence types within that group. Amoebae belonging to Group 2 cause the majority of reported human infections (both AK and Acanthamoeba GAE) and also constitute the majority of the strains isolated from the environment. As a complement to the morphologic classification, molecular analyses using nuclear small subunit ribosomal RNA (18S rRNA) gene sequences have divided Acanthamoeba into 17 sequence types (designated T1-T17, also called ribotypes or genotypes) (Corsaro and Venditti 2010; Gast 2001; Gast et al. Molecular and structural analysis of the 18S rRNA gene concluded that it is genetically most similar to the other Group 1 species within the Acanthamoeba genus, confirming the description of CDC:V621 as a new Acanthamoeba Group I strain. abstract: Acanthamoeba spp. are free‐living amoebae that are ubiquitous in natural environments. They can cause cutaneous, nasopharyngeal, and disseminated infection, leading to granulomatous amebic encephalitis (GAE) in immunocompromised individuals. In addition, they can cause amoebic keratitis in contact lens wearers. Acanthamoeba GAE is almost always fatal because of difficulty and delay in diagnosis and lack of optimal antimicrobial therapy. Here, we report the description of an unusual strain isolated from skin and brain of a GAE patient. The amoebae displayed large trophozoites and star‐shaped cysts, characteristics for acanthamoebas belonging to morphology Group 1. However, its unique morphology and growth characteristics differentiated this new strain from other Group 1 species. DNA sequence analysis, secondary structure prediction, and phylogenetic analysis of the 18S rRNA gene confirmed that this new strain belonged to Group 1, but that it was distinct from the other sequence types within that group. Thus, we hereby propose the establishment of a new species, Acanthamoeba byersi n. sp. as well as a new sequence type, T18, for this new strain. To our knowledge, this is the first report of a Group 1 Acanthamoeba that is indisputably pathogenic in humans. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618466/ doi: 10.1111/jeu.12069 id: cord-032979-jle66lmn author: ROMMEREIM, D. N. title: Reproduction, Growth, and Development of Rats during Chronic Exposure to Multiple Field Strengths of 60-Hz Electric Fields date: 1990-04-17 words: 6167.0 sentences: 325.0 pages: flesch: 56.0 cache: ./cache/cord-032979-jle66lmn.txt txt: ./txt/cord-032979-jle66lmn.txt summary: journal: Fundam Appl Toxicol Female rats were mated, and sperm-positive animals randomly distributed among four groups: sham-exposed or exposed to 10, 65, or 130 kV/m, 60-Hz vertical electric fields. Female rats were mated, and sperm-positive animals randomly distributed among four groups: sham-exposed or exposed to 10, 65, or 130 kV/m, 60-Hz vertical electric fields. Accordingly, in the study reported here we tested for a treatment-related response, utilizing multiple exposure groups, including 65 -cV/m (effective field strength) as used in our arevious experiments; 130 kV/m which was :wice as strong as that used in the previous ,vork and had been shown to be tolerated by •ats (Rommereim et al, 1989) ; the lowest evel of exposure (10 kV/m) was chosen to deineate the response curve at lower field strengths or possibly to determine a no-obierved-effect level; and the fourth group was sham-exposed as a control. Mean number of live fetuses per litter was less in rats exposed to the 130 kV/m field, but it was not statistically different from the control group {p = 0.33). abstract: Reproduction, Growth, and Development of Rats during Chronic Exposure to Multiple Field Strengths of 60-Hz Electric Fields. ROMMEREIM, D. N., ROMMEREIM, R. L., SIKOV, M. R., BUSCHBOM, R. L., AND ANDERSON, L. E. (1990). Fundam. Appl. Toxicol. 14, 608–621. A study with multiple exposure groups and large group sizes was performed to establish whether exposure to 60-Hz electric fields would result in reproductive and developmental toxicity. A response model was developed from previous results and tested in groups of rats exposed to electric fields at various field strengths. Female rats were mated, and sperm-positive animals randomly distributed among four groups: sham-exposed or exposed to 10, 65, or 130 kV/m, 60-Hz vertical electric fields. Animals were exposed for 19 hr/day throughout the experiment. During gestation, exposure to the higher field strengths resulted in slightly depressed weight gains of dams. Offspring were born in the field and remained with their dams through the suckling period. Numbers of pups per litter and pup mortality did not differ among the exposure groups. Dams exposed at 65 kV/m lost slightly more weight through the lactation period than the control group. Male pups exposed to higher field strengths gained slightly less weight from 4 to 21 days of age than did sham-exposed animals. At weaning, two F(1) females per litter (randomly selected) continued on the same exposure regimen were mated at 11 weeks of age to unexposed males, and euthanized at 20 days of gestation. Uterine contents were evaluated, and all live fetuses were weighed and examined for external, visceral, and skeletal malformations. Fertility and gestational weight gain of F(1) females were not affected by exposure, nor was prenatal viability or fetal body weight. No significant increase in the incidence of litters with malformations was observed. Although no developmental toxicity was detected, exposures produced physical changes in the dams, evidenced as a rust-colored deposit on the muzzle and ears (chromodac-ryorrhea) that increased in incidence and severity at 65 and 130 kV/m. Incidence of chromodac-ryorrhea was not significantly different between sham-exposed rats and those exposed at 10 kV/m. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529033/ doi: 10.1093/toxsci/14.3.608 id: cord-103779-qobzttqa author: Rachwal, S. title: 5.01 1,2,3-Triazoles date: 2008-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Rapid progress in the synthetic application of benzotriazole derivatives in the last 20 years has resulted in over 1000 scientific papers on the subject. This fact is reflected in Section 5.01.7, which involves almost a half of the volume of this chapter. The section is arranged according to hybridization of the C-α atom and atomic numbers of the atoms in positions β and γ to allow an easy access to the material of interest. Recent discovery of copper catalysis in [3+2] cycloadditions of azides to acetylenes, the so-called ‘click chemistry’, which boosted application of the 1,2,3-triazole derivatives, especially in medicinal chemistry, is presented in Section 5.01.9. From the point of view of practical applications, Section 5.01.11 is organized according to the number, position, and combination of the substituents at the aromatic rings. Another novel feature that has no precedence in the previous editions of Comprehensive Heterocyclic Chemistry is an addition of triazole and benzotriazole complexes with various transitions metals to Section 5.01.4. url: https://api.elsevier.com/content/article/pii/B9780080449920005010 doi: 10.1016/b978-008044992-0.00501-0 id: cord-261380-xms5su6w author: Rahmani, Hamid title: Interferon β-1b in treatment of severe COVID-19: a randomized clinical trial date: 2020-08-24 words: 2770.0 sentences: 170.0 pages: flesch: 51.0 cache: ./cache/cord-261380-xms5su6w.txt txt: ./txt/cord-261380-xms5su6w.txt summary: Among an open-label, randomized clinical trial, adult patients (≥ 18 years old) with severe COVID-19 were randomly assigned (1:1) to the IFN group or the control group. According to the presence of this evidence, IFN β was considered as a promising option for the treatment of In this open-label, randomized clinical trial, efficacy and safety of IFN β-1b in the treatment of patients with severe CoVID-19 were assessed. This open-label, randomized clinical trial was designed to evaluate the efficacy and safety of IFN β-1b in the treatment of patients with CoVID19 Adult patients (≥ 18 years old) with positive PCR and clinical symptoms/signs of pneumonia (including dyspnea, cough and fever), peripheral oxygen saturation (SPO 2 ) ≤ 93 % in ambient air or arterial oxygen partial pressure to fractional inspired oxygen (PaO 2 /FiO 2 ) < 300 or SPO 2 /FiO 2 < 315 and lung involvement in chest imaging were included. abstract: In this study, efficacy and safety of interferon (IFN) β-1b in the treatment of patients with severe COVID-19 were evaluated. Among an open-label, randomized clinical trial, adult patients (≥ 18 years old) with severe COVID-19 were randomly assigned (1:1) to the IFN group or the control group. Patients in the IFN group received IFN β-1b (250 mcg subcutaneously every other day for two consecutive weeks) along with the national protocol medications while in the control group, patients received only the national protocol medications (lopinavir/ritonavir or atazanavir/ritonavir plus hydroxychloroquine for 7-10 days). The primary outcome of the study was time to clinical improvement. Secondary outcomes were in-hospital complications and 28-daymortality. Between April 20 and May 20, 2020, 80 patients were enrolled and finally 33 patients in each group completed the study. Time to clinical improvment in the IFN group was significantly shorter than the control group ([9(6-10) vs. 11(9-15) days respectively, p=0.002, HR= 2.30; 95% CI: 1.33-3.39]). At day 14, the percentage of discharged patients was 78.79% and 54.55% in the IFN and control groups respectively (OR= 3.09; 95% CI: 1.05-9.11, p=0.03). ICU admission rate in the control group was significantly higher than the IFN group (66.66% vs. 42.42%, p = 0.04). The duration of hospitalization and ICU stay were not significantly different between the groups All-cause 28-day mortality was 6.06% and 18.18% in the IFN and control groups respectively (p = 0.12). IFN β-1b was effective in shortening the time to clinical improvement without serious adverse events in patients with severe COVID-19. Furthermore, admission in ICU and need for invasive mechanical ventilation decreased following administration of IFN β-1b. Although 28-day mortality was lower in the IFN group, further randomized clinical trials with large sample size are needed for exact estimation of survival benefit of IFN β-1b. url: https://doi.org/10.1016/j.intimp.2020.106903 doi: 10.1016/j.intimp.2020.106903 id: cord-274121-3w6kc0c9 author: Ramiro, Sofia title: Historically controlled comparison of glucocorticoids with or without tocilizumab versus supportive care only in patients with COVID-19-associated cytokine storm syndrome: results of the CHIC study date: 2020-07-20 words: 5757.0 sentences: 267.0 pages: flesch: 47.0 cache: ./cache/cord-274121-3w6kc0c9.txt txt: ./txt/cord-274121-3w6kc0c9.txt summary: Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. Objectives To prospectively investigate in patients with severe coVid-19-associated cytokine storm syndrome (css) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. ► A strategy involving a course of high-dose glucocorticoids, followed by tocilizumab if needed, has shown to accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation compared with supportive care only in COVID-19-associated CSS. abstract: OBJECTIVES: To prospectively investigate in patients with severe COVID-19-associated cytokine storm syndrome (CSS) whether an intensive course of glucocorticoids with or without tocilizumab accelerates clinical improvement, reduces mortality and prevents invasive mechanical ventilation, in comparison with a historic control group of patients who received supportive care only. METHODS: From 1 April 2020, patients with COVID-19-associated CSS, defined as rapid respiratory deterioration plus at least two out of three biomarkers with important elevations (C-reactive protein >100 mg/L; ferritin >900 µg/L; D-dimer >1500 µg/L), received high-dose intravenous methylprednisolone for 5 consecutive days (250 mg on day 1 followed by 80 mg on days 2–5). If the respiratory condition had not improved sufficiently (in 43%), the interleukin-6 receptor blocker tocilizumab (8 mg/kg body weight, single infusion) was added on or after day 2. Control patients with COVID-19-associated CSS (same definition) were retrospectively sampled from the pool of patients (n=350) admitted between 7 March and 31 March, and matched one to one to treated patients on sex and age. The primary outcome was ≥2 stages of improvement on a 7-item WHO-endorsed scale for trials in patients with severe influenza pneumonia, or discharge from the hospital. Secondary outcomes were hospital mortality and mechanical ventilation. RESULTS: At baseline all patients with COVID-19 in the treatment group (n=86) and control group (n=86) had symptoms of CSS and faced acute respiratory failure. Treated patients had 79% higher likelihood on reaching the primary outcome (HR: 1.8; 95% CI 1.2 to 2.7) (7 days earlier), 65% less mortality (HR: 0.35; 95% CI 0.19 to 0.65) and 71% less invasive mechanical ventilation (HR: 0.29; 95% CI 0.14 to 0.65). Treatment effects remained constant in confounding and sensitivity analyses. CONCLUSIONS: A strategy involving a course of high-dose methylprednisolone, followed by tocilizumab if needed, may accelerate respiratory recovery, lower hospital mortality and reduce the likelihood of invasive mechanical ventilation in COVID-19-associated CSS. url: https://doi.org/10.1136/annrheumdis-2020-218479 doi: 10.1136/annrheumdis-2020-218479 id: cord-332735-vfnbs2jn author: Rebmann, Terri title: Infection preventionists'' experience during the first months of the 2009 novel H1N1 influenza A pandemic date: 2009-12-31 words: 7904.0 sentences: 412.0 pages: flesch: 56.0 cache: ./cache/cord-332735-vfnbs2jn.txt txt: ./txt/cord-332735-vfnbs2jn.txt summary: Reference materials needed for current and future pandemics Topics that require development into quick reference materials ranked by order of importance* Infection prevention guidance for nonacute care settings (ambulatory care, home health, physician offices, and others) Infection prevention guidance related to occupational health issues Evidence-based information for physician education Patient and family educational materials that are brief (eg, 1-page fact sheet) and available in multiple languages Patient management materials that are brief (eg, patient placement/isolation, PPE use, and others) Isolation precautions materials that are brief and simple: electronic format preferred Communication procedures when supplies run out Infection prevention guidance for pediatric facilities Resource management tool for supply allocation during a variety of events Screening tools and forms that are simple to use Algorithm/check list outlining steps of an outbreak investigation *Order of importance determined by the Nominal Group Method. abstract: Background A novel strain of influenza A (H1N1) was identified in April 2009 and developed into a pandemic by June 2009. This rapid and unexpected event had enormous implications for infection preventionists (IP) internationally. Lessons learned from this event should guide future pandemic planning efforts. Methods Focus groups were conducted at the Association for Professionals in Infection Control and Epidemiology, Inc, (APIC) 2009 conference to evaluate IPs' experience with the novel H1N1 influenza pandemic and assess their perceived needs related to novel H1N1 topics and products required for future education and reference materials. Results Forty IPs (37 from the United States and 3 international) participated in the focus groups. Needed reference materials identified by attendees included infection prevention guidance for nonacute care settings; occupational health polices; and brief, multilanguage patient/family educational materials. Educational topics on which IPs need to be trained include isolation precautions/personal protective equipment recommendations for novel H1N1 patients, coordination between hospitals and community response agencies, and surge management. The rapidly changing and conflicting recommendations related to patient management made responding to this event challenging. IPs require synthesized infection prevention guidelines developed in a concise, real-time format. Conclusion IPs must continue to partner with public health and other response agencies to address gaps in pandemic planning. url: https://api.elsevier.com/content/article/pii/S0196655309008232 doi: 10.1016/j.ajic.2009.09.003 id: cord-290256-mkfg7nar author: Ren, Zhigang title: A Randomized, Open‐label, Controlled Clinical Trial of Azvudine Tablets in the Treatment of Mild and Common COVID‐19, A Pilot Study date: 2020-07-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Coronavirus disease 2019 (COVID‐19) has spread worldwide. To date, no specific drug for COVID‐19 has been developed. Thus we performed this randomized, open‐label, controlled clinical trial (ChiCTR2000029853) in China. A total of 20 mild and common COVID‐19 patients were enrolled and randomly assigned to receive azvudine and symptomatic treatment (FNC group), or standard antiviral and symptomatic treatments (control group). The mean times of the first nucleic acid negative conversion (NANC) of 10 patients in the FNC group and 10 patients in the control group were 2.60 (SD 0.97; range 1–4) days and 5.60 (SD 3.06; range 2–13) days, respectively (p = 0.08). The mean times of the first NANC of 4 newly diagnosed subjects in the FNC group and 10 subjects in the control group were 2.50 (SD 1.00; range 2–4) days and 9.80 (SD 4.73; range 3–19) days, respectively (starting from the initial treatment) (p = 0.01). No adverse events occurred in the FNC group, while 3 adverse events occurred in the control group (p = 0.06). The preliminary results showed that FNC treatment in the mild and common COVID‐19 may shorten the NANC time versus standard antiviral treatment. Therefore, clinical trials of FNC treating COVID‐19 with larger sample size are warranted. url: https://www.ncbi.nlm.nih.gov/pubmed/32837847/ doi: 10.1002/advs.202001435 id: cord-331270-12zx0o2p author: Rico, Timóteo Matthies title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial date: 2020-09-30 words: 5886.0 sentences: 290.0 pages: flesch: 50.0 cache: ./cache/cord-331270-12zx0o2p.txt txt: ./txt/cord-331270-12zx0o2p.txt summary: title: Use of Text Messaging (SMS) for the Management of Side Effects in Cancer Patients Undergoing Chemotherapy Treatment: a Randomized Controlled Trial All text messages were sent to the intervention group patients in an automated and tailored way by our app called cHEmotHErApp. Side effects experienced by patients were verified using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30). In our previous study, we showed the acceptance and perception of cancer patients undergoing chemotherapy on an outpatient basis receiving daily text messages about prevention and managing side effects, as well as emotional support [30] . To our knowledge, the present study is the first clinical trial employing text messaging (SMS) with preventative advice and side effect management tips sent to cancer patients in outpatient chemotherapy. abstract: Cancer patients are often not sufficiently oriented to manage side effects at home. Sending text messages with self-care guidelines aimed managing side effects is the main objective of this randomized controlled trial. Patients who started outpatient chemotherapy treatment between March and December 2017 at a hospital in southern Brazil were invited to participate in this study and were allocated to the intervention or control group (ratio 1: 1). Each patient in the intervention group received a daily SMS (short message service) with some guidance on management or prevention of side effects. All text messages were sent to the intervention group patients in an automated and tailored way by our app called cHEmotHErApp. Side effects experienced by patients were verified using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30). Results showed intervention group patients experienced fewer side effects compared to the control group in cycle 1 (p < 0.05), in general. In addition, intervention group experienced less nausea in relation to the control group, in the cycle 1 and cycle 2 (p < 0.05). This study indicate text messaging may be a tool for supporting side effect management in patients receiving chemotherapy. This study was enrolled in ClinicalTrials.gov with the identification number NCT03087422. This research was performed in accordance with the Declaration of Helsinki. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10916-020-01663-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1007/s10916-020-01663-x doi: 10.1007/s10916-020-01663-x id: cord-326723-jiauk4fq author: Risalde, María A title: Pathogenic mechanisms implicated in the intravascular coagulation in the lungs of BVDV-infected calves challenged with BHV-1 date: 2013-03-18 words: 5800.0 sentences: 283.0 pages: flesch: 44.0 cache: ./cache/cord-326723-jiauk4fq.txt txt: ./txt/cord-326723-jiauk4fq.txt summary: The aim of this study was to clarify the mechanisms responsible for vascular changes occurring in the lungs of calves infected with bovine viral diarrhea virus (BVDV) and challenged later with bovine herpesvirus type 1 (BHV-1), evaluating the role of MΦs in the development of pathological lesions in this organ. Therefore, the aim of this study was to clarify the mechanisms responsible for ultrastructural and histopathological changes occurring in the lungs of calves pre-infected with BVDV and challenged later with BHV-1, as well as to analyze the role of MΦs in the appearance of the lesions. According to this, in the course of certain acute viral infections, platelets may be activated in vivo, leading to their degranulation, Figure 6 Pro-inflammatory cytokines in the lungs of calves with and without pre-existing BVDV challenged with BHV-1.1. abstract: Resistance to respiratory disease in cattle requires host defense mechanisms that protect against pathogens which have evolved sophisticated strategies to evade them, including an altered function of pulmonary macrophages (MΦs) or the induction of inflammatory responses that cause lung injury and sepsis. The aim of this study was to clarify the mechanisms responsible for vascular changes occurring in the lungs of calves infected with bovine viral diarrhea virus (BVDV) and challenged later with bovine herpesvirus type 1 (BHV-1), evaluating the role of MΦs in the development of pathological lesions in this organ. For this purpose, pulmonary lesions were compared between co-infected calves and healthy animals inoculated only with BHV-1 through immunohistochemical (MAC387, TNFα, IL-1α, iNOS, COX-2 and Factor-VIII) and ultrastructural studies. Both groups of calves presented important vascular alterations produced by fibrin microthrombi and platelet aggregations within the blood vessels. These findings were earlier and more severe in the co-infected group, indicating that the concomitance of BVDV and BHV-1 in the lungs disrupts the pulmonary homeostasis by facilitating the establishment of an inflammatory and procoagulant environment modulated by inflammatory mediators released by pulmonary MΦs. In this regard, the co-infected calves, in spite of presenting a greater number of IMΦs than single-infected group, show a significant decrease in iNOS expression coinciding with the presence of more coagulation lesions. Moreover, animals pre-inoculated with BVDV displayed an alteration in the response of pro-inflammatory cytokines (TNFα and IL-1), which play a key role in activating the immune response, as well as in the local cell-mediated response. url: https://www.ncbi.nlm.nih.gov/pubmed/23506546/ doi: 10.1186/1297-9716-44-20 id: cord-270727-2dd3b7di author: Rivera-Benitez, José Francisco title: Co-infection of classic swine H1N1 influenza virus in pigs persistently infected with porcine rubulavirus date: 2016-02-29 words: 6469.0 sentences: 342.0 pages: flesch: 55.0 cache: ./cache/cord-270727-2dd3b7di.txt txt: ./txt/cord-270727-2dd3b7di.txt summary: A Student''s t-test assuming unequal variance and a significance level of P 0.05 was used to compare rectal temperatures and the viral load of PorPV and swH1N1 in different samples (nasal and oral swabs, respiratory tissues and SLO) between the single-infected groups to the co-infected group. In the nasal swabs, samples that tested positive for PorPV were detected from 24 h post-infection up to 28 DPI (PorPV/Mock and PorPV/swH1N1 groups) (Fig. 3a) , and there were no differences (P > 0.05) in the mean of viral loads at any time analysed for these two groups. The pigs in the Mock/swH1N1 group presented the lowest respiratory signs and rectal temperatures, with no pigs showing a difference in respiration or temperature after experimental infection, a finding that is in accordance with studies that used low-virulence swine influenza virus strains (Busquets et al., 2010) . abstract: Porcine rubulavirus (PorPV) and swine influenza virus infection causes respiratory disease in pigs. PorPV persistent infection could facilitate the establishment of secondary infections. The aim of this study was to analyse the pathogenicity of classic swine H1N1 influenza virus (swH1N1) in growing pigs persistently infected with porcine rubulavirus. Conventional six-week-old pigs were intranasally inoculated with PorPV, swH1N1, or PorPV/swH1N1. A mock-infected group was included. The co-infection with swH1N1 was at 44 days post-infection (DPI), right after clinical signs of PorPV infection had stopped. The pigs of the co-infection group presented an increase of clinical signs compared to the simple infection groups. In all infected groups, the most recurrent lung lesion was hyperplasia of the bronchiolar-associated lymphoid tissue and interstitial pneumonia. By means of immunohistochemical evaluation it was possible to demonstrate the presence of the two viral agents infecting simultaneously the bronchiolar epithelium. Viral excretion of PorPV in nasal and oral fluid was recorded at 28 and 52 DPI, respectively. PorPV persisted in several samples from respiratory tissues (RT), secondary lymphoid organs (SLO), and bronchoalveolar lavage fluid (BALF). For swH1N1, the viral excretion in nasal fluids was significantly higher in single-infected swH1N1 pigs than in the co-infected group. However, the co-infection group exhibited an increase in the presence of swH1N1 in RT, SLO, and BALF at two days after co-infection. In conclusion, the results obtained confirm an increase in the clinical signs of infection, and PorPV was observed to impact the spread of swH1N1 in analysed tissues in the early stage of co-infection, although viral shedding was not enhanced. In the present study, the interaction of swH1N1 infection is demonstrated in pigs persistently infected with PorPV. url: https://www.sciencedirect.com/science/article/pii/S0378113516300050 doi: 10.1016/j.vetmic.2016.01.005 id: cord-287431-bq0675h1 author: Romano, Mario R. title: Active e-learning in ophthalmology through live webinars: back to the theatre date: 2020-10-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1038/s41433-020-01239-6 doi: 10.1038/s41433-020-01239-6 id: cord-013444-5aei9kaz author: Ruzauskas, Modestas title: The Influence of Essential Oils on Gut Microbial Profiles in Pigs date: 2020-09-24 words: 9199.0 sentences: 443.0 pages: flesch: 45.0 cache: ./cache/cord-013444-5aei9kaz.txt txt: ./txt/cord-013444-5aei9kaz.txt summary: In this study, the microbial changes in pigs as experimental animals were assessed as influenced by consumption of oregano extract combination with peppermint and thyme essential oils. This study used pigs as an animal model for the assessment of the impact of consumption of Origanum vulgare plant extract combined with Mentha piperita and Thymus vulgaris essential oils on microbial profile in intestines. The results demonstrated that the combination of essential oils was non cytotoxic, and had a positive effect on the microbial composition in the large intestine of pigs due to significant increase in the number of probiotic bacteria. The aim of this study was to evaluate the cytotoxicity of Origanum vulgare plant extract, Mentha piperita, and Thymus vulgaris EOs and to evaluate microbial changes in the guts of pigs as experimental model by supplementing their diet with a combination of the aforementioned plant extract and two essential oils (EEOs) given in the form of bilayer coating tablets. abstract: SIMPLE SUMMARY: In recent years, the intake of ultra-processed foods has increased dramatically worldwide. Missing natural foods in the diet raise the need of biologically active food components that could compensate for this deficiency and help maintain proper immune status. In this study, the microbial changes in pigs as experimental animals were assessed as influenced by consumption of oregano extract combination with peppermint and thyme essential oils. The results demonstrated that the combination of plant extracts had a positive effect on the gastrointestinal tract of animals by increasing the number of probiotic bacteria. Based on the results obtained it may be outlined that the combination of oregano extract and peppermint and thyme essential oils can be promising ingredient as a functional component for the development of the new nutraceutical preparation. ABSTRACT: In recent years, the intake of ultra-processed foods has increased dramatically worldwide. Missing natural foods in the diet raise the need of biologically active food components that could compensate for this deficiency and help maintain proper immune status. This study used pigs as an animal model for the assessment of the impact of consumption of Origanum vulgare plant extract combined with Mentha piperita and Thymus vulgaris essential oils on microbial profile in intestines. A single group of weaned pigs received basal diet, while the other group basal diet supplemented with plant extract and two essential oils in the form of bilayer tablets prepared using “liquid/solid” phase technology. Metagenomic sequencing was performed with the aim to investigate changes of microbial communities in ileum, caecum, and colon. The results demonstrated that the combination of essential oils was non cytotoxic, and had a positive effect on the microbial composition in the large intestine of pigs due to significant increase in the number of probiotic bacteria. The amount of Lactobacillus was 2.5 times and Bifidobacterium 1.9 times higher in the animal group fed with supplement. The combination, however, had some negative impact on the variety of minor species in the distal part of the ileum. Additional studies need to be performed to obtain knowledge on how combinations of essential oils can change bacterial variety in the proximal part of the gastrointestinal tract. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7598605/ doi: 10.3390/ani10101734 id: cord-294175-nu6q2ddu author: Saitoh, Masayuki title: Ultrafiltration attenuates cardiopulmonary bypass–induced acute lung injury in a canine model of single-lung transplantation date: 2006-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Objective The purpose of this study was to investigate the effects of cardiopulmonary bypass and ultrafiltration on graft function in a canine single-lung transplantation model. Methods Fifteen left single-lung transplantations were done in weight-mismatched canine pairs. The animals were divided into 3 groups: group 1, in which transplantation was done without cardiopulmonary bypass; group 2, in which transplantation was done with cardiopulmonary bypass and in which the cardiopulmonary bypass flow was decreased slowly with controlled pulmonary artery pressure; and group 3, in which transplantation was done with cardiopulmonary bypass and ultrafiltration. Hemodynamic parameters and lung function were monitored for 6 hours after reperfusion. The grafts were harvested for histologic studies, myeloperoxidase assay, and real-time quantitive reverse transcription–polymerase chain reaction of mRNA encoding interleukin 6. Results The hemodynamic parameters were similar among the 3 groups. In group 1 Pao 2 and alveolar to arterial gradient for O2 levels were excellent throughout the 6-hour observation period, but in group 2 they progressively deteriorated. However, ultrafiltration significantly (P = .02) improved the Pao 2 level in group 3. On histology, interstitial edema and polynuclear cell infiltration were most marked in group 2 and significantly worse than in groups 1 and 3. Myeloperoxidase assay and real-time quantitative reverse transcription–polymerase chain reaction showed increased myeloperoxidase activity and interleukin 6 gene expression in group 2 grafts compared with group 1 grafts. Myeloperoxidase activity and interleukin 6 gene expression were suppressed with ultrafiltration. Conclusions Cardiopulmonary bypass had negative effects on the graft, but ultrafiltration attenuated acute lung dysfunction by reducing the inflammatory response. url: https://www.ncbi.nlm.nih.gov/pubmed/17140974/ doi: 10.1016/j.jtcvs.2006.08.020 id: cord-323906-ro078y52 author: Sardu, Celestino title: Implications of AB0 blood group in hypertensive patients with covid-19 date: 2020-08-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Hypertension is the most frequent co-morbidity in patients with covid-19 infection, and we might speculate that a specific blood group could play a key role in the clinical outcome of hypertensive patients with covid-19. METHODS: In this prospective study, we compared 0 vs. non-0 blood group in hypertensive patients with covid-19 infection. In these patients, we evaluated inflammatory and thrombotic status, cardiac injury, and death events. RESULTS: Patients in non-0 (n = 92) vs. 0 blood group (n = 72) had significantly different values of activated pro-thrombin time, D-dimer, and thrombotic indexes as Von Willebrand factor and Factor VIII (p < 0.05). Furthermore, patients in non-0 vs. 0 blood group had higher rate of cardiac injury (10 (13.9%) vs. 27 (29.3%)) and death, (6 (8.3%) vs. 18 (19.6%)), (p < 0.05). At the multivariate analysis, Interleukin-6 (1.118, CI 95% 1.067–1.171) and non-0 blood group (2.574, CI 95% 1.207–5.490) were independent predictors of cardiac injury in hypertensive patients with covid-19. D-dimer (1.082, CI 95% 1.027–1.140), Interleukin-6 (1.216, CI 95% 1.082–1.367) and non-0 blood group (3.706, CI 95% 1.223–11.235) were independent predictors of deaths events in hypertensive patients with covid-19. CONCLUSIONS: Taken together, our data indicate that non-0 covid-19 hypertensive patients have significantly higher values of pro-thrombotic indexes, as well as higher rate of cardiac injury and deaths compared to 0 patients. Moreover, AB0 blood type influences worse prognosis in hypertensive patients with covid-19 infection. url: https://doi.org/10.1186/s12872-020-01658-z doi: 10.1186/s12872-020-01658-z id: cord-284266-tbndldhr author: Schippa, Serena title: Nasal Microbiota in RSV Bronchiolitis date: 2020-05-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory Syncytial Virus (RSV) is the leading cause of bronchiolitis, and the severity may be influenced by the bacterial ecosystem. Our aim was to analyze the nasal microbiota from 48 infants affected by bronchiolitis from RSV virus and 28 infants with bronchiolitis but negative for the virus. Results showed a significantly lower biodiversity in the RSV-positive group with respect to the RSV-negative group, a specific microbial profile associated with the RSV-positive group different from that observed in the negative group, and significant modifications in the relative abundance of taxa in the RSV-positive group, as well as in the RSV-A group, with respect to the negative group. Furthermore, microbial network analyses evidenced, in all studied groups, the presence of two predominant sub-networks characterized by peculiar inter- and intra-group correlation patterns as well as a general loss of connectivity among microbes in the RSV-positive group, particularly in the RSV-A group. Our results indicated that infants with more severe bronchiolitis disease, caused by RSV-A infection, present significant perturbations of both the nasal microbiota structure and the microbial relationships. Patients with a milder bronchiolitis course (RSV-B-infected and patients who have cleared the virus) presented less severe alterations. url: https://doi.org/10.3390/microorganisms8050731 doi: 10.3390/microorganisms8050731 id: cord-326747-zwp13awk author: Sever, Mustafa title: Accidental Chlorine Gas Intoxication: Evaluation of 39 Patients date: 2009-12-28 words: 3975.0 sentences: 234.0 pages: flesch: 48.0 cache: ./cache/cord-326747-zwp13awk.txt txt: ./txt/cord-326747-zwp13awk.txt summary: In this paper, the socio-demographic and clinical characteristics of 39 accidentally exposed patients to chlorine gas are reported and different emergency treatment modalities are also discussed. In this paper, the social and demographic characteristics, clinical and laboratory findings of patients which have been accidentally exposed to chlorine gas due to chlorine tank explosion in Southeast of Turkey are reported. All hospitals'' emergency departments (ED) medical records which explain above were retrospectively analyzed for evaluation of accidental chlorine exposure patients for year 2007. Guloglu et al [9] reported that they preferred and recommended humidified O 2 and ß agonist combination applications to be the supportive therapy in their study group because of trachea-bronchitis and broncho-constriction and/ or pulmonary edema and Reactive Airway Dysfunction Syndrome effects of chlorine gas. abstract: BACKGROUND: Chlorine is a known pulmonary irritant gas that may cause acute damage in the respiratory system. In this paper, the socio-demographic and clinical characteristics of 39 accidentally exposed patients to chlorine gas are reported and different emergency treatment modalities are also discussed. METHODS: Two emergency departments applications were retrospectively analyzed for evaluation of accidental chlorine gas exposure for year 2007. Patients were classified into 3 groups according to severity of clinical and laboratory findings based on the literature and duration of land of stay in the emergency department. The first group was slightly exposed (discharged within 6 hours), second group moderately exposed (treated and observed for 24 hours), and third group was severely exposed (hospitalized). Most of the patients were initially treated with a combination of humidified oxygen, corticosteroids, and bronchodilators. RESULTS: The average age was 17.03 ± 16.01 years (95% CI). Seven (17.9%) of them were female and 29 (74.4%) were children. Twenty-four patients (61.5%) were included in the first, nine (23.1%) were in second and six (15.4%) were in the third group. The presenting symptoms were cough, nausea, and vomiting and conjunctiva hyperemia for the first group, first groups symptoms plus dyspnea for the second group. Second groups symptoms plus palpitation, weakness and chest tightness were for the third group. Cough and dyspnea were seen in 64.1% and 30.8% of the patients respectively. No patients died. CONCLUSIONS: The authors recommend that non symptomatic or slightly exposed patients do not need any specific treatment or symptomatic treatment is sufficient. KEYWORDS: Accidental; Chlorine exposure; Chlorine gas; Chlorine intoxication; Emergency department url: https://www.ncbi.nlm.nih.gov/pubmed/22481989/ doi: 10.4021/jocmr2009.12.1283 id: cord-209697-bfc4h4b3 author: Shanthakumar, Swaroop Gowdra title: Analyzing Societal Impact of COVID-19: A Study During the Early Days of the Pandemic date: 2020-10-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In this paper, we collect and study Twitter communications to understand the societal impact of COVID-19 in the United States during the early days of the pandemic. With infections soaring rapidly, users took to Twitter asking people to self isolate and quarantine themselves. Users also demanded closure of schools, bars, and restaurants as well as lockdown of cities and states. We methodically collect tweets by identifying and tracking trending COVID-related hashtags. We first manually group the hashtags into six main categories, namely, 1) General COVID, 2) Quarantine, 3) Panic Buying, 4) School Closures, 5) Lockdowns, and 6) Frustration and Hope}, and study the temporal evolution of tweets in these hashtags. We conduct a linguistic analysis of words common to all hashtag groups and specific to each hashtag group and identify the chief concerns of people as the pandemic gripped the nation (e.g., exploring bidets as an alternative to toilet paper). We conduct sentiment analysis and our investigation reveals that people reacted positively to school closures and negatively to the lack of availability of essential goods due to panic buying. We adopt a state-of-the-art semantic role labeling approach to identify the action words and then leverage a LSTM-based dependency parsing model to analyze the context of action words (e.g., verb deal is accompanied by nouns such as anxiety, stress, and crisis). Finally, we develop a scalable seeded topic modeling approach to automatically categorize and isolate tweets into hashtag groups and experimentally validate that our topic model provides a grouping similar to our manual grouping. Our study presents a systematic way to construct an aggregated picture of peoples' response to the pandemic and lays the groundwork for future fine-grained linguistic and behavioral analysis. url: https://arxiv.org/pdf/2010.15674v1.pdf doi: nan id: cord-266597-v5glur2c author: Sheng, Hui H title: Elevated adipogenesis of marrow mesenchymal stem cells during early steroid-associated osteonecrosis development date: 2007-10-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Increased bone marrow lipid deposition in steroid-associated osteonecrosis (ON) implies that abnormalities in fat metabolism play an important role in ON development. The increase in lipid deposition might be explained by elevated adipogenesis of marrow mesenchymal stem cells (MSCs). However, it remains unclear whether there is a close association between elevated adipogenesis and steroid-associated ON development. OBJECTIVE: The present study was designed to test the hypothesis that there might be a close association between elevated adipogenesis and steroid-associated ON development. METHODS: ON rabbit model was induced based on our established protocol. Dynamic-MRI was employed for local intra-osseous perfusion evaluation in bilateral femora. Two weeks after induction, bone marrow was harvested for evaluating the ability of adipogenic differentiation of marrow MSCs at both cellular and mRNA level involving adipogenesis-related gene peroxisome proliferator-activated receptor gamma2 (PPARγ2). The bilateral femora were dissected for examining marrow lipid deposition by quantifying fat cell number, fat cell size, lipid deposition area and ON lesions. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON occurrence, the rabbits were divided into ON(+ )(with at least one ON lesion) group and ON(- )(without ON lesion) group. For investigating association among adipogenesis, lipid deposition and perfusion function with regard to ON extension, the ON(+ )rabbits were further divided into sub-single-lesion group (SON group: with one ON lesion) and sub-multiple-lesion group (MON group: with more than one ON lesion). RESULTS: Local intra-osseous perfusion index was found lower in either ON(+ )or MON group when compared to either ON(- )or SON group, whereas the marrow fat cells number and area were much larger in either ON(+ )or MON group as compared with ON(- )and SON group. The adipogenic differentiation ability of MSCs and PPARγ2 expression in either ON(+ )or MON group were elevated significantly as compared with either ON(- )or SON group. CONCLUSION: These findings support our hypothesis that there is a close association between elevated adipogenesis and steroid-associated osteonecrosis development. url: https://www.ncbi.nlm.nih.gov/pubmed/17937789/ doi: 10.1186/1749-799x-2-15 id: cord-333334-90q1xkld author: Shengchen, D. title: Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial date: 2019-06-20 words: 3880.0 sentences: 182.0 pages: flesch: 38.0 cache: ./cache/cord-333334-90q1xkld.txt txt: ./txt/cord-333334-90q1xkld.txt summary: title: Evaluation of a molecular point-of-care testing for viral and atypical pathogens on intravenous antibiotic duration in hospitalized adults with lower respiratory tract infection: a randomized clinical trial OBJECTIVES: The primary objective was to evaluate whether a molecular point-of-care test (POCT) for viral and atypical pathogens added to routine real-time PCR could reduce duration of intravenous antibiotics in hospitalized patients with lower respiratory tract infection (LRTI) compared with routine real-time PCR. The median and interquartile range of the primary outcome (duration of intravenous antibiotics) and secondary outcomes, including length of hospital stay, cost of intravenous antibiotics and cost of hospitalization, were calculated and the difference between intervention and control group was compared using the Wilcoxon rank-sum test. In conclusion, this study found the addition of molecular POCT testing to routine real-time PCR testing for respiratory viruses and atypical pathogens might help to reduce intravenous antibiotic use in LRTI patients without resulting in adverse outcomes. abstract: OBJECTIVES: The primary objective was to evaluate whether a molecular point-of-care test (POCT) for viral and atypical pathogens added to routine real-time PCR could reduce duration of intravenous antibiotics in hospitalized patients with lower respiratory tract infection (LRTI) compared with routine real-time PCR. METHODS: In this single-centre, open-label, randomized controlled study, we enrolled hospitalized adults diagnosed with LRTI. Patients were randomized to an intervention group (POCT FilmArray Panel for 20 viruses, atypical pathogens and bacteria plus routine real-time PCR) or a control group (routine real-time PCR for ten pathogens). The primary outcome was duration of intravenous antibiotics during hospitalization. The secondary outcomes included length of stay, cost of hospitalization and de-escalation within 72 hours and between 72 hours and 7 days. Intention-to-treat analysis was used. RESULTS: Between October 2017 and July 2018, we enrolled 800 eligible patients (398 in the intervention group and 402 in the control group). Duration of intravenous antibiotics in the intervention group was shorter than in the control (7.0 days (interquartile range (IQR) 5.0–9.0) versus 8.0 days (IQR 6.0–11.0); p <0.001). Length of hospital stay in the intervention group was significantly shorter (8.0 days (IQR 7.0–11.0) versus 9.0 days (IQR 7.0–12.0; p <0.001) and the cost of hospitalization in the intervention group was significantly lower ($1804.7 (IQR 1298.4–2633.8) versus $2042.5 (IQR 1427.4–2926.2); p 0.002) than control group. More patients in the intervention group achieved de-escalation within 72 hours (7.9%, 29/367 versus 3.2%, 12/377; p 0.005) and between 72 hours and 7 days (29.7%, 109/367 versus 22.0%, 83/377; p 0.024). CONCLUSIONS: Use of molecular POCT testing for respiratory viruses and atypical pathogens might help to reduce intravenous antibiotic use in hospitalized LRTI patients. CLINICAL TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT03391076. url: https://doi.org/10.1016/j.cmi.2019.06.012 doi: 10.1016/j.cmi.2019.06.012 id: cord-193497-qqrhvlm5 author: Shoghri, Ahmad El title: Identifying highly influential travellers for spreading disease on a public transport system date: 2020-04-03 words: 5889.0 sentences: 299.0 pages: flesch: 46.0 cache: ./cache/cord-193497-qqrhvlm5.txt txt: ./txt/cord-193497-qqrhvlm5.txt summary: For instance previous work has explored the impact of recurring patterns inherent in human mobility on disease spread, but has not considered other dimensions such as the distance travelled or the number of encounters. In this paper we study three aspects of mobility behaviour, i.e. the degree of exploration, the distance travelled and the number of encounters of passengers using the Sydney bus network in the context of infectious disease spread. An increase in the infection probability on the other hand, amplifies the spreading power of all mobility groups, especially for passengers who regularly visit the same places and travel short distances, until reaching a saturation point at a probability of 0.5. Interestingly, the averages of received infections per individual is nearly the same across all the groups with a value just divide individuals into explorers and returners, but to distinguish them further along other dimensions such as the distance travelled and the connectivity as their spreading abilities differ. abstract: The recent outbreak of a novel coronavirus and its rapid spread underlines the importance of understanding human mobility. Enclosed spaces, such as public transport vehicles (e.g. buses and trains), offer a suitable environment for infections to spread widely and quickly. Investigating the movement patterns and the physical encounters of individuals on public transit systems is thus critical to understand the drivers of infectious disease outbreaks. For instance previous work has explored the impact of recurring patterns inherent in human mobility on disease spread, but has not considered other dimensions such as the distance travelled or the number of encounters. Here, we consider multiple mobility dimensions simultaneously to uncover critical information for the design of effective intervention strategies. We use one month of citywide smart card travel data collected in Sydney, Australia to classify bus passengers along three dimensions, namely the degree of exploration, the distance travelled and the number of encounters. Additionally, we simulate disease spread on the transport network and trace the infection paths. We investigate in detail the transmissions between the classified groups while varying the infection probability and the suspension time of pathogens. Our results show that characterizing individuals along multiple dimensions simultaneously uncovers a complex infection interplay between the different groups of passengers, that would remain hidden when considering only a single dimension. We also identify groups that are more influential than others given specific disease characteristics, which can guide containment and vaccination efforts. url: https://arxiv.org/pdf/2004.01581v1.pdf doi: nan id: cord-103538-vh6ma7k7 author: Smaldino, Paul E. title: Coupled Dynamics of Behavior and Disease Contagion Among Antagonistic Groups date: 2020-10-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Disease transmission and behavior change are both fundamentally social phenomena. Behavior change can have profound consequences for disease transmission, and epidemic conditions can favor the more rapid adoption of behavioral innovations. We analyze a simple model of coupled behavior-change and infection in a structured population characterized by homophily and outgroup aversion. Outgroup aversion slows the rate of adoption and can lead to lower rates of adoption in the later-adopting group or even behavioral divergence between groups when outgroup aversion exceeds positive ingroup influence. When disease dynamics are coupled to the behavior-adoption model, a wide variety of outcomes are possible. Homophily can either increase or decrease the final size of the epidemic depending on its relative strength in the two groups and on R0 for the infection. For example, if the first group is homophilous and the second is not, the second group will have a larger epidemic. Homophily and outgroup aversion can also produce dynamics suggestive of a “second wave” in the first group that follows the peak of the epidemic in the second group. Our simple model reveals complex dynamics that are suggestive of the processes currently observed under pandemic conditions in culturally and/or politically polarized populations such as the United States. url: https://doi.org/10.1101/2020.06.17.157511 doi: 10.1101/2020.06.17.157511 id: cord-298582-25qn9d15 author: Snyder, N.L. title: 9.05 Technology-Enabled Synthesis of Carbohydrates date: 2014-02-18 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Automated solid-phase oligosaccharide synthesis has revolutionized the emerging field of glycomics. The automation process, in which selectively functionalized monosaccharide building blocks are added sequentially to a growing oligosaccharide chain connected via an inert linker to a solid support, has been used to prepare a number of biologically relevant oligosaccharide-based constructs in record time and on scales that would have been impossible using standard solution-phase synthetic techniques. This review highlights recent developments in automated solid-phase oligosaccharide synthesis including engineering advancements that have led to the design of a fully automated platform, new and improved linker strategies that have broadened the scope of the chemical reactions that can be used in automation, and recent developments in the synthesis of functionalized monosaccharide building blocks. The automated solid-phase synthesis of biologically relevant carbohydrate constructs including bacterial and viral antigens, cancer antigens, vaccine candidates, and N-linked core oligosaccharides is also presented. url: https://www.sciencedirect.com/science/article/pii/B9780080977423009149 doi: 10.1016/b978-0-08-097742-3.00914-9 id: cord-259128-s27086aj author: Solano, Gloria I. title: Porcine reproductive and respiratory syndrome virus (PRRSv) interaction with Haemophilus parasuis date: 1997-04-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract The interaction of bacteria and virus has been well demonstrated in the pathogenesis of respiratory disease in swine. The interaction between porcine respiratory and reproductive syndrome virus (PRRSv) and Haemophilus parasuis has not been studied. We initiated studies to evaluate a possible effect of the PRRSv on the pathogenesis of polyserositis caused by H. parasuis. A group of 30 three week old piglets were distributed in 4 groups. Group I (10 pigs) was inoculated with PRRSv and H. parasuis. Group II (10 pigs) was inoculated with H. parasuis alone. Group III (5 pigs) was inoculated with virus alone and group IV (5 pigs) was inoculated with culture media. Lesions consisted of a severe fibrinous polyserositis affecting 7 of 10 animals in group II and a mild fibrinous pleuritis in 1 of 10 animals of group I. Three of ten animals dually infected with the two agents died during the course of the study. These animals had pulmonary congestion and focal lung hemorrhages. No other animals died from other groups. Group III and IV had no macroscopic lesions. Microscopically group III had interstitial pneumonia. Immunomodulating virus effect may explain the differences in terms of lesions severity between groups I and II. Septic shock was suspected as cause of sudden death. url: https://www.ncbi.nlm.nih.gov/pubmed/9220620/ doi: 10.1016/s0378-1135(96)01325-9 id: cord-014464-m5n250r2 author: Sole-Violan, J title: Lethal influenza virus A H1N1 infection in two relatives with autosomal dominant GATA-2 deficiency date: 2013-03-19 words: 98961.0 sentences: 5553.0 pages: flesch: 54.0 cache: ./cache/cord-014464-m5n250r2.txt txt: ./txt/cord-014464-m5n250r2.txt summary: Results In preliminary analysis of categorical data, a signifi cantly (Fisher exact test) greater proportion of patients with compared with without the following fi ndings did not survive; history of alcohol use (P = 0.05); the presence of lethargy (P = 0.01), confusion (P = 0.03), nausea (P = 0.04), abdominal pain (P = 0.02), or the need for vasopressors (P = 0.002), oxygen, mechanical ventilation, or steroids (all P = 0.004) at presentation; and excessive bleeding at surgery (P = 0.01). Methods To prospectively re-evaluate the normal range and to analyze the potential impact of biometric data on ICG-PDR, we measured ICG-PDR (i.v. injection of 0.25 mg/kg ICG; LiMON, Pulsion, Munich, Introduction Mixed venous oxygen saturation (SVO 2 ) represents a well-recognized parameter of oxygen delivery (DO 2 )-consumption (VO 2 ) mismatch and its use has been advocated in critically ill patients in order to guide hemodynamic resuscitation [1] and oxygen delivery optimization. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3642469/ doi: 10.1186/cc11953 id: cord-298931-n1se3ajb author: Stańdo, Mirella title: Omega-3 Polyunsaturated Fatty Acids EPA and DHA as an Adjunct to Non-Surgical Treatment of Periodontitis: A Randomized Clinical Trial date: 2020-08-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Periodontitis is a chronic multifactorial inflammatory disease that leads to the loss of supportive tissues around the teeth with gradual deterioration of masticatory function and esthetics, resulting eventually in the decrease of the life quality. Host immune response triggered by bacterial biofilm is responsible for the chronic periodontal inflammation and ongoing tissue loss. Omega-3 polyunsaturated fatty acids (PUFA) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) have anti-inflammatory properties, thus may be used for the treatment of chronic inflammatory diseases. In this study, we aimed to evaluate the effect of dietary supplementation with omega-3 PUFA in the patients with stage III and IV periodontitis. Thirty otherwise healthy patients were treated with scaling and root planning (SRP). In the test group (n = 16), patients were additionally supplemented with 2.6 g of EPA and 1.8 g of DHA. In the control group (n = 14), patients received only SRP. Periodontal examination was performed at baseline and three months following initial therapy. Salivary samples were taken twice at baseline and at the end of the experiment. We found that there was a statistically significant reduction in the bleeding on probing (BOP) and improvement of clinical attachment loss (CAL) at three months in the test group compared to the control group. Moreover, a statistically significant higher percentage of closed pockets (probing depth ≤ 4 mm without BOP) was achieved in the test group vs. control group after three months of treatment. Accordingly, the levels of pro-inflammatory cytokines/chemokines interleukin (IL)-8 and IL-17 were markedly lower, while the level of anti-inflammatory IL-10 was significantly higher in the salivary samples of the patients supplemented with omega-3 PUFA at three months in comparison to the patients treated with SRP alone. Our findings demonstrate that dietary intervention with high-dose of omega-3 PUFA during non-surgical therapy may have potential benefits in the management of periodontitis. url: https://www.ncbi.nlm.nih.gov/pubmed/32867199/ doi: 10.3390/nu12092614 id: cord-006578-wv3wc0ct author: Stevens, D. L. title: Invasive streptococcal infections date: 2001 words: 8839.0 sentences: 531.0 pages: flesch: 45.0 cache: ./cache/cord-006578-wv3wc0ct.txt txt: ./txt/cord-006578-wv3wc0ct.txt summary: The risk for secondary cases is likely related to close or intimate contact and crowding, as well as host factors such as: (1) active viral infections such as varicella or influenza; (2) recent surgical wounds and childbirth (author''s unpublished observations); (3) absence of type specific opsonic antibody against the group A streptococcus causing the index case; and (4) absence of neutralizing antibody against pyrogenic exotoxin A or B. 17 Streptococcal pyrogenic exotoxins A and B induce human mononuclear cells to synthesize not only TNFα 75 but also IL-1 76 and IL-6, [76] [77] [78] suggesting that TNF could mediate the fever, shock, and organ failure observed in patients with StrepTSS. Multi-locus enzyme electrophoresis demonstrates two patterns, which correspond to M-1 and M-3 type organisms that produce pyrogenic exotoxin A, a finding that fits epidemiologic studies implicating these strains in invasive group A streptococcal infections 54 in the United States. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102056/ doi: 10.1007/s101560100012 id: cord-009962-k3opc553 author: Stjernquist‐Desatnik, Anna title: Pharyngotonsillitis date: 2008-12-17 words: 5501.0 sentences: 317.0 pages: flesch: 32.0 cache: ./cache/cord-009962-k3opc553.txt txt: ./txt/cord-009962-k3opc553.txt summary: Acute rheumatic fever, the most serious nonsuppurative complication of beta-hemolytic group A streptococcal pharyngotonsillitis, is the leading cause of acquired heart disease among children in developing countries (5) . However, beta-hemolytic group A streptococci are amongst the most virulent human pathogens, and patients with pharyngotonsillitis caused by infection with this bacterium can be seriously affected with high fever, dysphagia and severe pain. The decline of acute rheumatic fever in the developed world may indeed be the result of routine antibiotic use for beta-hemolytic group A streptococcal pharyngotonsillitis, supporting the present principles of treatment. Penicillin V was detected in tonsillar surface fluid in a majority of patients on the first day of treatment of acute beta-hemolytic group A streptococcus pharyngotonsillitis, but despite a high concentration in serum, was rarely present on the 10th day or in healthy, treated subjects (81) . abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167632/ doi: 10.1111/j.1600-0757.2008.00282.x id: cord-312695-1uw8xcxw author: Sugiarto, Sarah title: Passive immunization does not provide protection against experimental infection with Mycoplasma haemofelis date: 2016-08-05 words: 8623.0 sentences: 370.0 pages: flesch: 51.0 cache: ./cache/cord-312695-1uw8xcxw.txt txt: ./txt/cord-312695-1uw8xcxw.txt summary: In the present study we investigated whether the passive transfer of antibodies from Mhf-recovered cats to naïve recipient cats provided protection against bacteremia and clinical disease following homologous challenge with Mhf; moreover, we characterized the immune response in the recipient cats. The present study aimed to investigate whether the passive transfer of antibodies from Mhf-recovered to naïve recipient cats induced partial or complete protection against bacteremia and clinical disease following homologous challenge with Mhf. Different parameters addressing the humoral and cellular immune response were monitored in passively immunized and control cats. Our study demonstrated that the passive transfer of antibodies from Mhf-recovered to naïve SPF cats does not prevent infection, high bacterial loads and the development of clinical signs following homologous challenge with Mhf. The passively immunized and control cats showed no differences in the onset and extent of bacteremia and anemia during the course of Mhf infection. abstract: Mycoplasma haemofelis (Mhf) is the most pathogenic feline hemotropic mycoplasma. Cats infected with Mhf that clear bacteremia are protected from Mhf reinfection, but the mechanisms of protective immunity are unresolved. In the present study we investigated whether the passive transfer of antibodies from Mhf-recovered cats to naïve recipient cats provided protection against bacteremia and clinical disease following homologous challenge with Mhf; moreover, we characterized the immune response in the recipient cats. Ten specified pathogen-free (SPF) cats were transfused with pooled plasma from cats that had cleared Mhf bacteremia; five control cats received plasma from naïve SPF cats. After homologous challenge with Mhf, cats were monitored for 100 days using quantitative PCR, hematology, blood biochemistry, Coombs testing, flow cytometry, DnaK ELISA, and red blood cell (RBC) osmotic fragility (OF) measurement. Passively immunized cats were not protected against Mhf infection but, compared to control cats, showed significantly higher RBC OF and B lymphocyte (CD45R/B220(+)) counts and occasionally higher lymphocyte, monocyte and activated CD4(+) T lymphocyte (CD4(+)CD25(+)) counts; they also showed higher bilirubin, total protein and globulin levels compared to those of control cats. At times of peak bacteremia, a decrease in eosinophils and lymphocytes, as well as subsets thereof (B lymphocytes and CD5(+), CD4(+) and CD8(+) T lymphocytes), and an increase in monocytes were particularly significant in the passively immunized cats. In conclusion, passive immunization does not prevent bacteremia and clinical disease following homologous challenge with Mhf, but enhances RBC osmotic fragility and induces a pronounced immune response. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13567-016-0361-x) contains supplementary material, which is available to authorized users. url: https://doi.org/10.1186/s13567-016-0361-x doi: 10.1186/s13567-016-0361-x id: cord-011147-55whf8md author: Sun, Hengchang title: Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection date: 2020-01-07 words: 7864.0 sentences: 424.0 pages: flesch: 56.0 cache: ./cache/cord-011147-55whf8md.txt txt: ./txt/cord-011147-55whf8md.txt summary: title: Oral delivery of Bacillus subtilis spores expressing Clonorchis sinensis paramyosin protects grass carp from cercaria infection Potential pathogenetic bacteria with lower abundance and higher abundances of candidate probiotics and bacteria associated with digestion in 1 × 10(11) CFU/g B.s-CotC-CsPmy spores administrated fishes could be detected compared with control group. In the present study, the specific IgM antibody levels in serum, bile, intestinal mucus, and skin mucus of grass carp orally administrated with different dosages of spores (B.s-CotC-CsPmy) were significantly increased with dosedependent from the 2nd week after the beginning of the immunization till to 6 weeks (Fig. 2) . Immune response induced by oral delivery of Bacillus subtilis spores expressing enolase of Clonorchis sinensis in grass carps (Ctenopharyngodon idellus) abstract: Clonorchis sinensis (C. sinensis), an important fishborne zoonotic parasite threatening public health, is of major socioeconomic importance in epidemic areas. Effective strategies are still urgently expected to prevent against C. sinensis infection. In the present study, paramyosin of C. sinensis (CsPmy) was stably and abundantly expressed on the surface of Bacillus subtilis spores. The recombinant spores (B.s-CotC-CsPmy) were incorporated in the basal pellets diet in three different dosages (1 × 10(5), 1 × 10(8), 1 × 10(11) CFU/g pellets) and orally administrated to grass carp (Ctenopharyngodon idella). The immune responses and intestinal microbiota in the treated grass carp were investigated. Results showed that specific anti-CsPmy IgM levels in sera, skin mucus, bile, and intestinal mucus, as well as mRNA levels of IgM and IgZ in the spleen and head kidney, were significantly increased in B.s-CotC-CsPmy-10(11) group. Besides, transcripts levels of IL-8 and TNF-αin the spleen and head kidney were also significantly elevated than the control groups. Moreover, mRNA levels of tight junction proteins in the intestines of B.s-CotC-CsPmy-10(11) group increased. Potential pathogenetic bacteria with lower abundance and higher abundances of candidate probiotics and bacteria associated with digestion in 1 × 10(11) CFU/g B.s-CotC-CsPmy spores administrated fishes could be detected compared with control group. The amount of metacercaria in per gram fish flesh was statistically decreased in 1 × 10(11) CFU/g B.s-CotC-CsPmy spores orally immunized group. Our work demonstrated that B. subtilis spores presenting CsPmy on the surface could be a promising effective, safe, and needle-free candidate vaccine against C. sinensis infection for grass carp. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00253-019-10316-0) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223688/ doi: 10.1007/s00253-019-10316-0 id: cord-275499-25dp6u68 author: Tan, Zhen title: Porcine Epidemic Diarrhea Altered Colonic Microbiota Communities in Suckling Piglets date: 2019-12-30 words: 4432.0 sentences: 244.0 pages: flesch: 47.0 cache: ./cache/cord-275499-25dp6u68.txt txt: ./txt/cord-275499-25dp6u68.txt summary: In this study, we successfully demonstrated that the microbial community structure of colonic mucosa and content differed significantly between healthy and PEDV-infected piglets. Likewise, previous research has shown that the proportions of Escherichia-Shigella, Enterococcus, Fusobacterium, and Veillonella increased significantly in PEDV-infected piglets, while those of short-chain fatty acid (SCFA)-producing bacteria (e.g., Rikenellaceae_RC9_gut_group, Butyricimonas, and Alistipes) underwent a decrease [21] . Some bacteria from Firmicutes and Bacteroidetes were enriched in healthy piglets, while some from Proteobacteria and Fusobacteria were more abundant in PEDV-infected groups. To better characterize the intestinal microbiomes of healthy versus PEDV-infected piglets, we recommend that future studies fully examine virome diversity using a larger sample size and metagenomic de novo sequencing of the gut microbial genome. Dynamic change of gut microbiota during porcine epidemic diarrhea virus infection in suckling piglets Changes in cecal microbiota community of suckling piglets infected with porcine epidemic diarrhea virus abstract: Porcine epidemic diarrhea (PED) is a major gastrointestinal disease afflicting suckling pigs that causes huge industrial economic losses. In this study, we investigated microbiota from the colonic mucosa and content in healthy and PED piglets. High-throughput 16S rRNA gene sequencing was performed to identify inter-group differences. Firmicutes, Fusobacteria, Proteobacteria, and Bacteroidetes were the top four affected phyla. The proportion of Proteobacteria was higher in infected than in healthy piglets, and the opposite was observed for Bacteroidetes (more than four-fold higher in the healthy group). In the infected group, Fusobacterium accounted for 36.56% and 21.61% in the colonic mucosa and contents, respectively, while in the healthy group, they comprised 22.53% and 12.67%, respectively. The percentage of Lactobacillus in healthy colons (15.63%) was considerably higher than that in the disease group (<10%). In both the colonic mucosa and contents, functional enrichment differed significantly between healthy and diseased groups. Overall, infection with the PED virus increased the proportion of harmful bacteria and decreased the proportion of beneficial bacteria in the colons of piglets. Targeting intestinal microbiota could be a promising method for PED prevention, thus opening new avenues for future research. url: https://doi.org/10.3390/genes11010044 doi: 10.3390/genes11010044 id: cord-022281-xn0cf33a author: Tanz, Robert R. title: Sore Throat date: 2009-05-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7155522/ doi: 10.1016/b978-0-7216-9131-2.50005-1 id: cord-007367-e31zhty6 author: Tassier, Troy title: Network position and health care worker infections date: 2015-09-07 words: 11003.0 sentences: 567.0 pages: flesch: 55.0 cache: ./cache/cord-007367-e31zhty6.txt txt: ./txt/cord-007367-e31zhty6.txt summary: We estimate, using an agent-based model, the effect of network position of different hospital worker groups on the spread of infectious diseases in a hospital. Following the theoretical discussion, we use our newly collected data on healthcare worker and patient contacts to model the spread of an infectious disease in a hospital setting. The model allows us to identify the healthcare worker groups that would be expected to play the largest role in the spread of infectious diseases, in terms of network position, in this hospital setting. Because of these difficulties we use a simulation approach to help us measure the average and marginal effects of individuals belonging to different worker groups in our hospital contact data. We discuss the data and use agent-based models to identify the healthcare workers whose position in the hospital contact network has the potential to create large numbers of infections in the hospital. abstract: We use a newly collected data set coupled with an agent-based model to study the spread of infectious disease in hospitals. We estimate the average and marginal infections created by various worker groups in a hospital as a function of their network position in order to identify groups most crucial in a hospital-based epidemic. Surprisingly, we find that many groups with primary patient care responsibilities play a small role in spreading an infectious disease within our hospital data set. We also demonstrate that the effect of different network positions can be as important as the effect of different transmission rates for some categories of workers. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7111609/ doi: 10.1007/s11403-015-0166-4 id: cord-003825-tkqxb1ql author: Toman, Miroslav title: Dynamics and Differences in Systemic and Local Immune Responses After Vaccination With Inactivated and Live Commercial Vaccines and Subsequent Subclinical Infection With PRRS Virus date: 2019-08-06 words: 6723.0 sentences: 395.0 pages: flesch: 49.0 cache: ./cache/cord-003825-tkqxb1ql.txt txt: ./txt/cord-003825-tkqxb1ql.txt summary: The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. Comparison of serum and oral fluid antibody responses after vaccination with modified live (MLV) porcine reproductive and respiratory syndrome virus (PRRSV) vaccine in PRRS endemic farms abstract: The goals of our study were to compare the immune response to different killed and modified live vaccines against PRRS virus and to monitor the antibody production and the cell mediated immunity both at the systemic and local level. In the experiment, we immunized four groups of piglets with two commercial inactivated (A1—Progressis, A2—Suivac) and two modified live vaccines (B3—Amervac, B4—Porcilis). Twenty-one days after the final vaccination, all piglets, including the control non-immunized group (C5), were i.n., infected with the Lelystad strain of PRRS virus. The serum antibody response (IgM and IgG) was the strongest in group A1 followed by two MLV (B3 and B4) groups. Locally, we demonstrated the highest level of IgG antibodies in bronchoalveolar lavages (BALF), and saliva in group A1, whereas low IgA antibody responses in BALF and feces were detected in all groups. We have found virus neutralization antibody at DPV 21 (days post vaccination) and higher levels in all groups including the control at DPI 21 (days post infection). Positive antigen specific cell-mediated response in lymphocyte transformation test (LTT) was observed in groups B3 and B4 at DPV 7 and in group B4 at DPV 21 and in all intervals after infection. The IFN-γ producing lymphocytes after antigen stimulation were found in CD4(−)CD8(+) and CD4(+)CD8(+) subsets of all immunized groups 7 days after infection. After infection, there were obvious differences in virus excretion. The virus was detected in all groups of piglets in serum, saliva, and occasionally in feces at DPI 3. Significantly lower virus load was found in groups A1 and B3 at DPI 21. Negative samples appeared at DPI 21 in B3 group in saliva. It can be concluded that antibodies after immunization and infection, and the virus after infection can be detected in all the compartments monitored. Immunization with inactivated vaccine A1—Progressis induces high levels of antibodies produced both systemically and locally. Immunization with MLV-vaccines (Amervac and Porcilis) produces sufficient antibody levels and also cell-mediated immunity. After infection virus secretion gradually decreases in group B3, indicating tendency to induce sterile immunity. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691355/ doi: 10.3389/fimmu.2019.01689 id: cord-022973-soaz8b74 author: Trivellini, Guido title: Nestedness of habitat specialists within habitat generalists in a butterfly assemblage date: 2016-09-25 words: 5103.0 sentences: 251.0 pages: flesch: 46.0 cache: ./cache/cord-022973-soaz8b74.txt txt: ./txt/cord-022973-soaz8b74.txt summary: Butterflies (Lepidoptera) are a well-studied insect group both taxonomically and ecologically (e.g. Gilbert, 1984; Kocher & Williams, 2000; Ghazoul, 2002; Stefanescu et al., 2004 Stefanescu et al., , 2011 , particularly because they interact with plants both as larval herbivores and adult pollinators (Borges et al., 2003; Hardy et al., 2007) and have different habitat requirements even at each life stage (New et al., 1995; Samways & Lu, 2007; Dennis, 2010) . E-mail: giuseppe.bogliani@unipv.it These largely specialised butterfly-habitat associations are influenced by many physical and biological factors (Leps & Spitzer, 1990; Spitzer et al., 1993) , including temperature, humidity, light levels, rainfall patterns, local microclimate conditions, grassland type and host-plant species richness and distribution (Hill et al., 2001; Meyer & Sisk, 2001; Collinge et al., 2003; Men endez et al., 2007) . To do this, we first defined the requirements, i.e., which habitat types positively or negatively correlate with species abundances, and then used a network-based approach (Bl€ uthgen et al., 2006) to analyse the degree of habitat use overlap within groups of species with similar habitat requirements. abstract: 1. The habitat requirements of a species are the resources, conditions and space required for survival and reproduction. The habitat requirements of butterflies have been well studied, but the extent to which individuals within a species and between species utilise and share the habitat is poorly known. 2. In a butterfly assemblage in northern Italy, we found that adults from 30 species avoid deciduous high‐density forests and their ecotones, and they were positively related to open areas and their ecotones. Besides these common features, five groups of species can be discriminated in relation to a gradient from open area to forest, and species within groups were not equally specialised, as observed from a bipartite network analysis. In particular, some species appeared to be specialised and others appeared to be generalist, suggesting a nested pattern of resource use, rather than a clustered pattern in which each species uses a different subset of habitat types. 3. The degree of variation in specialisation among species varied with the number of species falling in each group. Thus, an increased number of species, and thus possibly competition, is more likely to promote the co‐occurrence of generalist and specialised species (nested patterns) rather than an increased niche segregation among species. 4. Ascertaining how species overlap their habitat use at a local scale can be relevant for conservation purposes, because specialised populations are potentially more susceptible to network distortions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165506/ doi: 10.1111/icad.12193 id: cord-284301-fg3hk94b author: Umemura, Yutaka title: Hematological Phenotype of COVID-19-Induced Coagulopathy: Far from Typical Sepsis-Induced Coagulopathy date: 2020-09-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Blood coagulation disorders commonly occur with severe coronavirus disease 2019 (COVID-19). However, there is only limited evidence on differentiating the pattern of the hemostatic parameters from those of typical sepsis-induced coagulopathy (SIC). Methods: To elucidate the specific pattern of coagulopathy induced by COVID-19 pneumonia, this retrospective, observational study targeted consecutive adult patients with COVID-19-induced acute respiratory distress syndrome (ARDS) and compared hemostatic biomarkers with non-COVID-19-induced septic ARDS. Multilevel mixed-effects regression analysis was performed and Kaplan–Meier failure curves were constructed. Results: We enrolled 24 patients with COVID-19-induced ARDS and 200 patients with non-COVID-19-induced ARDS. Platelet count, antithrombin activity, and prothrombin time in the COVID-19 group were almost within normal range and time series alterations of these markers were significantly milder than the non-COVID-19 group (p = 0.052, 0.037, and 0.005, respectively). However, fibrin/fibrinogen degradation product and D-dimer were significantly higher in the COVID-19 group (p = 0.001, 0.002, respectively). COVID-19 patients had moderately high levels of thrombin–antithrombin complex and plasmin-alpha2-plasmin inhibitor complex but normal plasminogen activator inhibitor-1 level. Conclusions: The hematological phenotype of COVID-19-induced coagulopathy is quite different from that in typical SIC characterized by systemic hypercoagulation and suppressed fibrinolysis. Instead, local thrombus formation might be promoted in severe COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/32899532/ doi: 10.3390/jcm9092875 id: cord-304208-jwlc8fxj author: Vagni, Monia title: Coping With COVID-19: Emergency Stress, Secondary Trauma and Self-Efficacy in Healthcare and Emergency Workers in Italy date: 2020-09-03 words: 8630.0 sentences: 360.0 pages: flesch: 48.0 cache: ./cache/cord-304208-jwlc8fxj.txt txt: ./txt/cord-304208-jwlc8fxj.txt summary: Hence, this study explores the relationship between coping strategies used by healthcare and emergency workers in Italy to manage the stress factors related to the COVID-19 emergency, which may result in the risk of developing secondary trauma. As regards the stress that they experience, the literature clearly explains that healthcare and emergency workers who intervene in emergency situations are exposed to the risk of developing dysfunctional reactions that can be identified at different levelsphysical and/or physiological (e.g., psychosomatic disorders, sleep/wake cycle alterations, and sense of tiredness); emotional (e.g., irritability, nervousness, agitation, anger, low self-esteem, and guilt); cognitive (e.g., distractibility, sense of ineffectiveness, and negative anticipation of events); and relational (e.g., increase in conflicts within emergency teams and/or with their organization/institution, and social withdrawal)-and may also develop reactions from secondary trauma (Del Missier et al., 2008; Sbattella, 2009; Argentero and Setti, 2011; Fraccaroli and Balducci, 2011; Bellelli and Di Schiena, 2012; Walton et al., 2020) . abstract: Coping with the coronavirus disease (COVID-19) is a significant risk factor for the psychological distress of health workers. Hence, this study explores the relationship between coping strategies used by healthcare and emergency workers in Italy to manage the stress factors related to the COVID-19 emergency, which may result in the risk of developing secondary trauma. We study differences between healthcare (n = 121) and emergency workers (n = 89) in terms of their coping strategies, emergency stress, and secondary trauma, as well as the relationships of these differences to demographic variables and other stress factors (Instructions and Equipment). For this purpose, we collected data from participants through the following questionnaires online: Secondary Traumatic Stress Scale – Italian Version, The Coping Self-Efficacy Scale – Short Form, an original questionnaire on stressors, and the Emergency Stress Questionnaire (to assess organizational–relational, physical, decisional inefficacy, emotional, cognitive, and COVID-19 stress). We performed a t-test, correlational analysis, and hierarchical regression. The analyses reveal that compared with the emergency worker group, the health worker group has greater levels of emergency stress and arousal and is more willing to use problem-focused coping. Healthcare workers involved in the treatment of COVID-19 are exposed to a large degree of stress and could experience secondary trauma; hence, it is essential to plan prevention strategies for future pandemic situations. Moreover, individual efficacy in stopping negative emotions and thoughts could be a protective strategy against stress and secondary trauma. url: https://doi.org/10.3389/fpsyg.2020.566912 doi: 10.3389/fpsyg.2020.566912 id: cord-288552-7lp07v5i author: Vahedi, Ensieh title: The clinical value of two combination regimens in the Management of Patients Suffering from Covid-19 pneumonia: a single centered, retrospective, observational study date: 2020-06-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: There is no identified pharmacological therapy for COVID-19 patients, where potential therapeutic strategies are underway to determine effective therapy under such unprecedented pandemic. Therefore, combination therapies may have the potential of alleviating the patient’s outcome. This study aimed at comparing the efficacy of two different combination regimens in improving outcomes of patients infected by novel coronavirus (COVID-19). METHODS: This is a single centered, retrospective, observational study of 60 laboratory-confirmed COVID-19 positive inpatients (≥18 years old) at two wards of the Baqiyatallah Hospital, Tehran, Iran. Patient’s data including clinical and laboratory parameters were recorded. According to the drug regimen, the patients were divided into two groups; group I who received regimen I consisting azithromycin, prednisolone, naproxen, and lopinavir/ritonavir and group II who received regimen II including meropenem, levofloxacin, vancomycin, hydroxychloroquine, and oseltamivir. RESULTS: The oxygen saturation (SpO2) and temperature were positively changed in patients receiving regimen I compared to regimen II (P = 0.013 and P = 0.012, respectively). The serum level of C-reactive protein (CRP) changed positively in group I (P < 0.001). Although there was a significant difference in platelets between both groups (75.44 vs 51.62, P < 0.001), their change did not clinically differ between two groups. The findings indicated a significant difference of the average length of stay in hospitals (ALOS) between two groups, where the patients under regimen I showed a shorter ALOS (6.97 vs 9.93, P = 0.001). CONCLUSION: This study revealed the beneficial effect of the short-term use of low-dose prednisolone in combination with azithromycin, naproxen and lopinavir/ritonavir (regimen I), in decreasing ALOS compared to regimen II. Since there is still lack of evidence for safety of this regimen, further investigation in our ongoing follow-up to deal with COVID-19 pneumonia is underway. [Figure: see text] url: https://doi.org/10.1007/s40199-020-00353-w doi: 10.1007/s40199-020-00353-w id: cord-009797-8mdie73v author: Valle, Denis title: Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change date: 2018-08-26 words: 5624.0 sentences: 244.0 pages: flesch: 50.0 cache: ./cache/cord-009797-8mdie73v.txt txt: ./txt/cord-009797-8mdie73v.txt summary: title: Extending the Latent Dirichlet Allocation model to presence/absence data: A case study on North American breeding birds and biogeographical shifts expected from climate change The Latent Dirichlet Allocation (LDA) model is a mixed‐membership method that can represent gradual changes in community structure by delineating overlapping groups of species, but its use has been limited because it requires abundance data and requires users to a priori set the number of groups. Furthermore, by comparing the estimated proportion of each group for two time periods (1997–2002 and 2010–2015), our results indicate that nine (of 18) breeding bird groups exhibited an expansion northward and contraction southward of their ranges, revealing subtle but important community‐level biodiversity changes at a continental scale that are consistent with those expected under climate change. It is important to note that even in the absence of MM sampling units, LDA can still estimate well the true number of groups and has similar fit to the data as the other clustering approaches (results not shown). abstract: Understanding how species composition varies across space and time is fundamental to ecology. While multiple methods having been created to characterize this variation through the identification of groups of species that tend to co‐occur, most of these methods unfortunately are not able to represent gradual variation in species composition. The Latent Dirichlet Allocation (LDA) model is a mixed‐membership method that can represent gradual changes in community structure by delineating overlapping groups of species, but its use has been limited because it requires abundance data and requires users to a priori set the number of groups. We substantially extend LDA to accommodate widely available presence/absence data and to simultaneously determine the optimal number of groups. Using simulated data, we show that this model is able to accurately determine the true number of groups, estimate the underlying parameters, and fit with the data. We illustrate this method with data from the North American Breeding Bird Survey (BBS). Overall, our model identified 18 main bird groups, revealing striking spatial patterns for each group, many of which were closely associated with temperature and precipitation gradients. Furthermore, by comparing the estimated proportion of each group for two time periods (1997–2002 and 2010–2015), our results indicate that nine (of 18) breeding bird groups exhibited an expansion northward and contraction southward of their ranges, revealing subtle but important community‐level biodiversity changes at a continental scale that are consistent with those expected under climate change. Our proposed method is likely to find multiple uses in ecology, being a valuable addition to the toolkit of ecologists. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165608/ doi: 10.1111/gcb.14412 id: cord-014533-6qfecv5h author: Velasquez, T. title: ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016 date: 2016-09-29 words: 88380.0 sentences: 5139.0 pages: flesch: 52.0 cache: ./cache/cord-014533-6qfecv5h.txt txt: ./txt/cord-014533-6qfecv5h.txt summary: P. Tirapu; Navarro-Guillamón, L.; Cordovilla-Guardia, S.; Iglesias-Santiago, A.; Guerrero-López, F.; Fernández-Mondéjar, E.; Vidal, A.; Perez, M.; Juez, A.; Arias, N.; Colino, L.; Perez, J. Methods: This descriptive observational study was conducted on consecutive 100 pediatric surgical patients who admitted to PSICUs at Cairo University Hospitals starting from 1/6-1/12/2015.After approval by research ethics committee,informed consents were obtained from parents and pediatric cases aged from 1 month-18 years and stayed for > 48 h were enrolled.MPV and PLC were obtained and recorded at baseline(preoperative values),on the day of ICU admission(day 0),1 st ,2 nd ,3 rd ,5 th and 7 th days.To measure daily MPV changes; (ΔMPV) was constructed and computed where ΔMPV = ([MPVday(X) − MPVday (0)]/MPVday(0) × 100 %. Results: The results obtained after analyzing the two homogeneous groups according to age, gender, type of admission and severity influencing the physiotherapy care in ICU quality indicators, in the Sagrada Esperança clinic, highlights the decrease of the average number of days with mechanical ventilation but it is not observed a significant relation between physical therapy and this indicator (p = 0:06). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042925/ doi: 10.1186/s40635-016-0100-7 id: cord-280055-5iwo6tlb author: Vieira, Tiago title: The lose-lose dilemmas of Barcelona’s platform delivery workers in the age of COVID-19 date: 2020-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The abrupt lockdown experienced by a big part of the world population due to the COVID-19 pandemic has bestowed upon home delivery services an unexpected importance. Officially considered amongst “essential services”, their workers circulate freely while most people are advised (when not forced) to stay in their homes. The present paper explores how this context helps to shed light on the precarious situation of the majority of the platform delivery workers (PDW). This is done through in-depth, semi-structured interviews and digital ethnography of the interactions within a WhatsApp group. The main finding is that the COVID-19 context deepened the precarization of the PDW confronting them with four dilemmas from which there is no way out. url: https://api.elsevier.com/content/article/pii/S2590291120300486 doi: 10.1016/j.ssaho.2020.100059 id: cord-283177-qwinggg4 author: Viswanathan, Ramaswamy title: Support Groups and Individual Mental Health Care via Video Conferencing for Frontline Clinicians during the COVID-19 Pandemic date: 2020-06-23 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The current COVID-19 pandemic has put an enormous stress on the mental health of frontline healthcare workers. OBJECTIVE: Psychiatry departments in medical centers need to develop support systems to help our colleagues cope with this stress. METHODS: We developed recurring peer support groups via videoconferencing and telephone for physicians, resident physicians, and nursing staff, focusing on issues and emotions related to their frontline clinical work with COVID patients in our medical center which was designated as a COVID-only hospital by the state. These groups are led by attending psychiatrists and psychiatry residents. In addition, we also deployed a system of telehealth individual counseling by attending psychiatrists. RESULTS: Anxiety was high in the beginning of our weekly groups, dealing with fear of contracting COVID or spreading COVID to family members, and the stress of social distancing. Later the focus was also on the impairment of the traditional clinician patient relationship by the characteristics of this disease, and the associated moral challenges and trauma. Clinicians were helped to cope with these issues through group processes such as ventilation of feelings, peer support, consensual validation, and peer-learning, and interventions by group facilitators. People with severe anxiety or desiring confidentiality were helped through individual interventions. CONCLUSIONS: Our experience suggests that this method of offering telehealth peer support groups and individual counseling is a useful model for other centers to adapt, to emotionally support frontline clinical workers in this ongoing worldwide crisis. url: https://doi.org/10.1016/j.psym.2020.06.014 doi: 10.1016/j.psym.2020.06.014 id: cord-014868-kg96uvpi author: Vita, S. title: Evaluation of Total Proteins and Serum Protein Fractions in Cats Naturally Infected by Leishmania infantum–A Preliminary Study date: 2006 words: 1264.0 sentences: 62.0 pages: flesch: 52.0 cache: ./cache/cord-014868-kg96uvpi.txt txt: ./txt/cord-014868-kg96uvpi.txt summary: In canine leishmaniosis, laboratory parameters such as serum total proteins (TPs), albuminto-globulin (A/G) ratio, and single serum protein fractions have been proposed for their particular diagnostic significance and for monitoring the progress of the disease (Ceci and Petazzi, 1983; Bizzetti, 1998; Ciaramella and De Luna, 1999) . During the progress of feline leishmaniosis, some authors have observed increased serum TPs associated with hyper-γ-globulinemia and hypoalbuminemia with inversion of the A/G ratio and changes in the α-globulin fractions (Laurelle-Magalon and Toga, 1996 Hervas et al., 1999; Ozon et al., 1998; Pennisi, 2002; Poli et al., 2002) . To the best of our knowledge, the evaluation of serum protein changes has only been reported once for a group of FIV infected cats positive to PCR assay for Leishmania infantum (Pennisi et al., 2000) . The objective of this study was to evaluate serum TPs and some protein fractions in cats positive to Leishmania. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089196/ doi: 10.1007/s11259-006-0073-1 id: cord-018813-9hoksa86 author: Waito, Marianne title: A Mathematical Model of Cytokine Dynamics During a Cytokine Storm date: 2016-02-17 words: 2893.0 sentences: 156.0 pages: flesch: 52.0 cache: ./cache/cord-018813-9hoksa86.txt txt: ./txt/cord-018813-9hoksa86.txt summary: The dynamics of cytokines during normal immune responses and even more so during storms are highly complex and little is known about specific interactions [5, 27] . Combining these approaches can result in major advancements in both the understanding of cancer and immune system dynamics including cytokine interactions, with the potential to identify strategies to control toxic cytokine storms [26] . Following administration of a highly attenuated virus to mice with leukocytes lacking the type I IFN receptor, a deadly cytokine storm developed leading to death in only 24 h. Data was collected and provided by Dr. Byram Bridle, Dr. Scott Walsh and Alexandra Rasiuk who study the role of type I IFN signalling in the regulation of cytokine responses at the OVC. The model provides an accurate fit to the cytokine time series data for both IFNAR-knockout and wild-type mice (not shown). abstract: Cytokine storms are a potentially fatal exaggerated immune response consisting of an uncontrolled positive feedback loop between immune cells and cytokines. The dynamics of cytokines are highly complex and little is known about specific interactions. Researchers at the Ontario Veterinary College have encountered cytokine storms during virotherapy. Multiple mouse trials were conducted where a virus was injected into mice whose leukocytes lacked expression of the type I interferon receptor. In each case a rapid, fatal cytokine storm occurred. A nonlinear differential equation model of the recorded cytokine amounts was produced to obtain some information on their mutual interactions. Results provide insight into the complex mechanism that drives the storm and possible ways to prevent such immune responses. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123790/ doi: 10.1007/978-3-319-30379-6_31 id: cord-004373-nmnssoeb author: Wall, Jonathan T. title: What about lay counselors’ experiences of task-shifting mental health interventions? Example from a family-based intervention in Kenya date: 2020-02-20 words: 9305.0 sentences: 436.0 pages: flesch: 46.0 cache: ./cache/cord-004373-nmnssoeb.txt txt: ./txt/cord-004373-nmnssoeb.txt summary: We aimed to describe how lay counselors experience role shifts and associated outcomes, such as Keywords: Mental health, Lay counselors, Task shifting, Africa, Burnout, Motivation, Self-efficacy, Stress, Family therapy, Children Intrinsic and extrinsic forces, beliefs, and ideals that incline an individual to pursue and maintain their position as a lay counselor [22] An individual''s perceptions and assessments of their capability to be competent and effective in their counseling role [23] The physical, psychological, emotional, and social consequences that affect a lay counselor due to trying to fulfill the duties and responsibilities expected of them by their clients, supervisors, and communities Because the intervention was designed with the goal of minimizing the added burden for lay providers (described below), it offers a helpful lens and case study for understanding the specific contribution of role shifts in relation to other stressors associated with lay counselor experiences. abstract: BACKGROUND: A key focus of health systems strengthening in low- and middle-income countries is increasing reach and access through task-shifting. As such models become more common, it is critical to understand the experiences of lay providers because they are on the forefront for delivering care services. A greater understanding would improve lay provider support and help them provide high-quality care. This is especially the case for those providing mental health services, as providing psychological care may pose unique stressors. We sought to understand experiences of lay counselors, focusing on identity, motivation, self-efficacy, stress, and burnout. The goal was to understand how taking on a new provider role influences their lives beyond simply assuming a new task, which would in turn help identify actionable steps to improve interventions with task-shifting components. METHODS: Semi-structured interviews (n = 20) and focus group discussions (n = 3) were conducted with three lay counselor groups with varying levels of experience delivering a community-based family therapy intervention in Eldoret, Kenya. Thematic analysis was conducted, including intercoder reliability checks. A Stress Map was created to visualize stress profiles using free-listing and pile-sorting data collected during interviews and focus group discussions. RESULTS: Counselors described high intrinsic motivation to become counselors and high self-efficacy after training. They reported positive experiences in the counselor role, with new skills improving their counseling and personal lives. As challenges arose, including client engagement difficulties and balancing many responsibilities, stress and burnout increased, dampening motivation and self-efficacy. In response, counselors described coping strategies, including seeking peer and supervisor support, that restored their motivation to persevere. At case completion, they again experienced high self-efficacy and a desire to continue. CONCLUSIONS: Findings informed suggestions for ways to incorporate support for lay providers into task-shifting interventions at initiation, during training, and throughout implementation. These include acknowledging and preparing counselors for challenges during training, increasing explicit attention to counselor stress in supervision, fostering peer support among lay providers, and ensuring a fair balance between workload and compensation. Improving and building an evidence base around practices for supporting lay providers will improve the effectiveness and sustainability of lay provider-delivered interventions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031864/ doi: 10.1186/s13033-020-00343-0 id: cord-333745-nwnt2tde author: Wang, Yi title: Clinical characteristics and laboratory indicator analysis of 67 COVID-19 pneumonia patients in Suzhou, China date: 2020-10-12 words: 4399.0 sentences: 209.0 pages: flesch: 51.0 cache: ./cache/cord-333745-nwnt2tde.txt txt: ./txt/cord-333745-nwnt2tde.txt summary: RESULTS: The study found that fibrinogen (FIB) was increased in 45 (65.2%) patients, and when FIB reached a critical value of 4.805 g/L, the sensitivity and specificity、DA, helping to distinguish general and severe cases, were 100 and 14%、92.9%, respectively, which were significantly better than those for lymphocyte count and myoglobin. In a comparison of patients in Group A with patients in Group B, the lymphocyte count absolute value (L), myoglobin (MB) and fibrinogen of COVID-19 pneumonia patients in Group A were significantly higher than those in Group B, with statistically significant differences (P ≤ 0.001) ( Table 4 ). Laboratory data showed that the WBC, N%, and CRP in Group B COVID-19 pneumonia patients were significantly higher than those of Group A patients, and the differences were statistically significant (P < 0.05). abstract: BACKGROUND: Sudden exacerbations and respiratory failure are major causes of death in patients with severe coronavirus disease 2019(COVID-19) pneumonia, but indicators for the prediction and treatment of severe patients are still lacking. METHODS: A retrospective analysis of 67 collected cases was conducted and included approximately 67 patients with COVID-19 pneumonia who were admitted to the Suzhou Fifth People’s Hospital from January 1, 2020 to February 8, 2020. The epidemiological, clinical and imaging characteristics as well as laboratory data of the 67 patients were analyzed. RESULTS: The study found that fibrinogen (FIB) was increased in 45 (65.2%) patients, and when FIB reached a critical value of 4.805 g/L, the sensitivity and specificity、DA, helping to distinguish general and severe cases, were 100 and 14%、92.9%, respectively, which were significantly better than those for lymphocyte count and myoglobin. Chest CT images indicated that the cumulative number of lung lobes with lesions in severe patients was significantly higher than that in general patients (P < 0.05), and the cumulative number of lung lobes with lesions was negatively correlated with lymphocyte count and positively correlated with myoglobin and FIB. Our study also found that there was no obvious effect of hormone therapy in patients with severe COVID-19. CONCLUSIONS: Based on the retrospective analysis, FIB was found to be increased in severe patients and was better than lymphocyte count and myoglobin in distinguishing general and severe patients. The study also suggested that hormone treatment has no significant effect on COVID-19. url: https://www.ncbi.nlm.nih.gov/pubmed/33046047/ doi: 10.1186/s12879-020-05468-8 id: cord-285136-07jcccv9 author: Woo, Yu Ri title: Air Pollution and Atopic Dermatitis (AD): The Impact of Particulate Matter (PM(10)) on an AD Mouse-Model date: 2020-08-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Air pollution reportedly contributes to the development and exacerbation of atopic dermatitis (AD). However, the exact mechanism underlying this remains unclear. To examine the relationship between air pollution and AD, a clinical, histological, and genetic analysis was performed on particulate matter (PM)-exposed mice. Five-week-old BALB/c mice were randomly divided into four groups (control group, ovalbumin (OVA) group, PM group, OVA + PM group; n = 6) and treated with OVA or PM(10,) alone or together. Cutaneous exposure to OVA and PM(10) alone resulted in a significant increase in skin severity scores, trans-epidermal water loss (TEWL) and epidermal thickness compared to the control group at Week 6. The findings were further accentuated in the OVA + PM group showing statistical significance over the OVA group. A total of 635, 501, and 2149 genes were found to be differentially expressed following OVA, PM(10), and OVA + PM(10) exposure, respectively. Strongly upregulated genes included RNASE2A, S100A9, SPRR2D, THRSP, SPRR2A1 (OVA vs. control), SPRR2D, S100A9, STFA3, CHIL1, DBP, IL1B (PM vs. control) and S100A9, SPRR2D, SPRR2B, S100A8, SPRR2A3 (OVA + PM vs. control). In comparing the groups OVA + PM with OVA, 818 genes were differentially expressed with S100A9, SPRR2B, SAA3, S100A8, SPRR2D being the most highly upregulated in the OVA + PM group. Taken together, our study demonstrates that PM(10) exposure induces/aggravates skin inflammation via the differential expression of genes controlling skin barrier integrity and immune response. We provide evidence on the importance of public awareness in PM-associated skin inflammation. Vigilant attention should be paid to all individuals, especially to those with AD. url: https://www.ncbi.nlm.nih.gov/pubmed/32846909/ doi: 10.3390/ijms21176079 id: cord-266722-qfn2dc1q author: Wormser, Gary P. title: Non-Sexually transmitted infectious diseases of the oral, nasal, and vaginal mucosae date: 1987-06-30 words: 5482.0 sentences: 272.0 pages: flesch: 38.0 cache: ./cache/cord-266722-qfn2dc1q.txt txt: ./txt/cord-266722-qfn2dc1q.txt summary: Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these "nonpathogens." This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). The skin lesions are tender and consist of papules and clear vesicles with a surrounding zone of erythema.617 Pharyngitis with tonsillar exudate persisting for 4 or more days with a negative throat culture for group A streptococci, or occurring in association with diffuse lymphadenopathy, splenomegaly or with many atypical lymphocytes on blood smear suggests the possibility of infectious mononucleosis (IM) (Epstein-Barr virus). abstract: Abstract The skin and mucous membranes are the principal barriers to invasion of the body by microorganisms. Besides functioning as a mechanical barrier, the mucosae are endowed with an array of still poorly characterized specific and nonspecific host defense capabilities. These include the production of mucus, secretory immunoglobulin (IgA), lysozyme, lactoferrin, and alpha-antitrypsin, in conjunction with a low-grade exudation of leukocytes.1 In addition, the mucosal surfaces of the upper respiratory, gastrointestinal, and lower vaginal and urinary tracts support a large number of “nonpathogenic” microorganisms that comprise the so-called “normal flora.” This commensal flora plays an important and complex role in protecting the host from microbial invasion. Mechanisms for this protection likely include the following: (1) competition for the same nutrients (interference); (2) competition for the same receptors on host cells (tropism); (3) production of bacteriocins, that is, bacterial products that are toxic to other organisms, usually of the same species; and (4) stimulation of crossprotective immune factors such as the “natural antibodies.”1 The “normal” flora is inconstant and may be altered by dietary factors, debilitation, hormonal events (such as menstruation, pregnancy, and possibly use of oral contraceptives), personal hygiene, medications, intercurrent infection, and probably many others. Antibiotic therapy and menstruation can have a profound effect on the composition of this group of microorganisms.2 Disturbance of the delicate host-commensal relationship may cause a clinically significant infection due to these “nonpathogens.” This may occur in response to the aforementioned factors (eg, pregnancy predisposing to vaginal candidiasis) or because of disruption of the anatomic barrier (eg, local mucosal infection at a site of trauma, or injury from cytotoxic drugs) or in association with exogenous infection (eg, rhinoviral infection leading to secondary bacterial otitis media). Invasion by “normal flora” may result in serious systemic illness. A clear example of the latter is the development of infective endocarditis caused by viridans streptococci following a dental procedure. url: https://api.elsevier.com/content/article/pii/0738081X87900137 doi: 10.1016/0738-081x(87)90013-7 id: cord-342381-i63r6los author: Wu, Huiyue title: Design and development of an immersive virtual reality news application: a case study of the SARS event date: 2020-09-17 words: 9052.0 sentences: 435.0 pages: flesch: 48.0 cache: ./cache/cord-342381-i63r6los.txt txt: ./txt/cord-342381-i63r6los.txt summary: For example, virtual reality technology has raised new requirements for the traditional news production process [14, 28, 45] , and the change of perspective caused by the disappearance of the physical screen and the appearance of interactive elements brings a new challenge to the narrative frame of journalism [13] . 3 Regarding narrative frame, the production of VR news is moving away from the linear and planned storytelling structure adopted by traditional news: In immersive VR news, the audience can not only understand the whole news event from an omniscient perspective (e.g., Kiya) 4 but also participate in the news story as bystanders (e.g., Use of Force) 5 or even become the protagonist to experience the feelings of the parties involved (e.g., Across the Line). abstract: In recent years, virtual reality (VR) technologies have been applied to the field of journalism, where the concept of immersive VR news has been proposed. However, despite the fanfare, strong response, and sensational effect caused by its advent, immersive VR news remains a novel journalism paradigm that faces new challenges in its production process. Currently, there is a lack of a unified design framework, and, since most studies in this area have focused on non-interactive VR news, the understanding of the effects of more interactive VR technologies on the news consumer remains inadequate. In this study, we propose a more practical design framework for immersive VR news products. Following this framework, we designed a VR news application and conducted user evaluation in terms of media effects and user experience. Based on the experimental findings, which demonstrated that non-interactive VR news products resulted in a distracting user experience and less immersion, while interactive VR news offered improved media effects and user experience, we then derived concrete design guidelines for immersive VR news design. Finally, we highlight that this study provides a theoretical and practical reference framework for the further study of VR news. url: https://doi.org/10.1007/s11042-020-09863-w doi: 10.1007/s11042-020-09863-w id: cord-003673-u7711eb4 author: Xiong, Xiao-Li title: Emodin Rescues Intrahepatic Cholestasis via Stimulating FXR/BSEP Pathway in Promoting the Canalicular Export of Accumulated Bile date: 2019-05-22 words: 6866.0 sentences: 470.0 pages: flesch: 61.0 cache: ./cache/cord-003673-u7711eb4.txt txt: ./txt/cord-003673-u7711eb4.txt summary: Real-time PCR and Western blotting was employed to detect the mRNA and protein levels of BSEP in LO2 cell, rat primary hepatocytes and liver tissue. More importantly, our previous work revealed that emodin could alleviate intrahepatic cholestasis by promoting the expression of liver farnesoid X receptor (FXR), small heterodimer partner (SHP), uridine diphosphate glucuronosyltransferase 2 family polypeptide B4 (UGT2B4), and bile salt export pump (BSEP), which are related to the synthesis, detoxification, and transportation process of Bas (Ding et al., 2016) . Therefore, this research used the LO2 cell line and ANIT-induced rat model to find how emodin interfered with the BSEP signaling pathway to alleviate intrahepatic cholestasis. As shown in Figure 8D , compared with the untreated cells, the emodin group showed significantly elevated mRNA levels of FXR and BSEP. For the LO2 cell experiment, the mRNA and protein expressions of FXR and BSEP were significantly elevated in the emodin group compared with control group. abstract: AIM: Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular export in the treatment of cholestasis. In this study, we investigated the stimulatory effect of emodin on BSEP signaling pathway in cholestasis. METHODS: Cell and animal experiments were given different concentrations of emodin. The BSEP upstream molecule farnesoid X receptor was down-regulated by small interfering RNA (siRNA) technology or guggulsterones and up-regulated by lentivirus or GW4064. Real-time PCR and Western blotting was employed to detect the mRNA and protein levels of BSEP in LO2 cell, rat primary hepatocytes and liver tissue. Immunohistochemistry (IHC) was used to examine the expression of BSEP in liver tissues. Rat liver function and pathological changes of liver tissue were performed by biochemical test and hematoxylin and eosin (HE) staining. RESULTS: Emodin could increase the mRNA and protein expression of BSEP and FXR. When down-regulating farnesoid X receptor expression with the siRNA or inhibitor guggulsterones, and up-regulating farnesoid X receptor expression with the lentivirus or agonist GW4064, emodin could increase the mRNA level of BSEP and FXR and the protein level of BSEP, FXR1, and FXR2. Emodin also had a notable effect on rat primary hepatocytes experiment, rat pathological manifestation, BSEP, FXR1, and FXR2 positive staining in liver tissues and the test of liver function. CONCLUSION: Emodin has a protective effect and a rescue activity on cholestasis via stimulating FXR/BSEP pathways in promoting the canalicular export of accumulated bile. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6540617/ doi: 10.3389/fphar.2019.00522 id: cord-005379-5x4deimg author: Xu, Jing-Xiu title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels date: 2015-08-19 words: 5602.0 sentences: 342.0 pages: flesch: 48.0 cache: ./cache/cord-005379-5x4deimg.txt txt: ./txt/cord-005379-5x4deimg.txt summary: title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels To determine dietary selenium (Se) status regulates the transcriptions of selenoproteome and activities of selenoenzymes in chicken kidney, 1-day-old chickens received low Se (0.028 mg Se per kg of diet) or super-nutritional Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. Low Se significantly reduced total antioxidant capability (T-AOC), glutathione (GSH) content, but malondialdehyde (MDA) content in the kidney increased and decreased glutathione peroxidase (Gpx) and thioredoxin reductase (TrxR) activity with changes in their mRNA levels. Se could protect the renal antioxidant function from oxidative damage [14] , and Se deficiency or excess causes a lot of selenoprotein resultant metabolic disorders in pig kidney [15] . abstract: To determine dietary selenium (Se) status regulates the transcriptions of selenoproteome and activities of selenoenzymes in chicken kidney, 1-day-old chickens received low Se (0.028 mg Se per kg of diet) or super-nutritional Se (3.0 or 5.0 mg Se per kg of diet) in their diets for 8 weeks. It was observed that dietary low or super-nutritional Se did not make renal appearance pathological changes in chicken. Low Se significantly reduced total antioxidant capability (T-AOC), glutathione (GSH) content, but malondialdehyde (MDA) content in the kidney increased and decreased glutathione peroxidase (Gpx) and thioredoxin reductase (TrxR) activity with changes in their mRNA levels. Super-nutritional Se (3.0 mg/kg) increased T-AOC and GSH contents then made them reduce, but it reduced MDA content significantly, elevated then reduced Gpx activity, and decreased TrxR activity with changes in their mRNA levels. Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS. At super-nutritional Se, most selenoproteins were upregulated in chicken kidney, but Sepp2 and Sep15 was only upregulated in Se excess (5.0 mg/kg) bird. These results indicated that dietary Se status stabilizes normal renal physiology function via regulation of the selenoprotemic transcriptions and selenoenzyme activities in avian. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12011-015-0470-9) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091239/ doi: 10.1007/s12011-015-0470-9 id: cord-006984-x1r99rlm author: Yokhana, J. S. title: Effect of insoluble fiber supplementation applied at different ages on digestive organ weight and digestive enzymes of layer-strain poultry date: 2015-11-14 words: 7434.0 sentences: 400.0 pages: flesch: 61.0 cache: ./cache/cord-006984-x1r99rlm.txt txt: ./txt/cord-006984-x1r99rlm.txt summary: At wk 10, relative weights of liver and gizzard of Group IF were heavier (P < 0.05) than other treatments; activities of pepsin, GP, trypsin and chymotrypsin of IF pullets were significantly greater than other treatments as was mRNA expression for pepsinogens A (25.9 vs. The first experiment was designed to determine whether the addition of a commercial IF product (Arbocel RC, JRS Co. Inc., Rosenberg, Germany) in the diets of young layer-strain pullets between the ages of 8 and 18 wk influenced supply organ growth and proteolytic enzyme activities in the proventriculus, pancreas, and small intestine. Feeding the IF diet to the older pullets (13 to 18 wk of age) for 5 wk (Group C-IF) had no significant effect (compared to controls) on activities of pepsin or the three pancreatic enzymes measured (Table 4 ). abstract: Two experiments were conducted to study effects of dietary insoluble fiber (IF) on digestive enzyme function in layer poultry. In Experiment 1, 8 wk old pullets were fed a control diet (Group C) or a diet (Group IF) supplemented with 1% IF (Arbocel RC). After 5 wk, 6 pullets per group were killed and organ samples collected. The remaining pullets in Group C were divided into two groups: half were fed the control diet (Group C) and half were given the IF diet (Group C-IF). Similarly, half the pullets in Group IF continued on the IF diet (Group IF) and half on the control diet (Group IF-C). At 10 wk, organ samples were collected. BW at wk 5 (IF, 1364.8g; C, 1342.9g) and 10 wk (IF, 1678.1g; IF-C, 1630.5g; C-IF, 1617.1g; C, 1580.4g) were not different. At wk 5, the relative proventricular weight (0.41 g/100g BW) and activities of pepsin (75.3 pepsin units/g proventriculus/min) and pancreatic general proteolytic activity (GP) (122.9 μmol tyrosine produced/g tissue) were greater (P < 0.05) than those of Group C (proventricular relative weight, 0.36; pepsin activity, 70.6; GP activity, 94.3). At wk 10, relative weights of liver and gizzard of Group IF were heavier (P < 0.05) than other treatments; activities of pepsin, GP, trypsin and chymotrypsin of IF pullets were significantly greater than other treatments as was mRNA expression for pepsinogens A (25.9 vs. 22.9) and C (13.1 vs. 10.8). In Experiment 2, 19 wk old hens were fed a control diet or a diet containing 0.8% IF (Arbocel RC) for 12 wk. Final BW after 12 wk was not different (IF, 1919.4 g; C, 1902.1 g). Pancreatic GP activity was greater (P < 0.05) in Group IF hens than Group C at wk 12 (122.2 vs. 97.0 μmol tyrosine released/min/g tissue)) as was relative gizzard weight (1.32 vs 1.10 g/100 g BW). The significantly improved digestive organ weights and enzyme activities in IF pullets may contribute to an improvement in feed utilization. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7107128/ doi: 10.3382/ps/pev336 id: cord-284635-79cgct71 author: Zanuzzi, C.N. title: Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits date: 2011-08-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant Solanum glaucophyllum. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by S. glaucophyllum is discussed. url: https://api.elsevier.com/content/article/pii/S0034528811002700 doi: 10.1016/j.rvsc.2011.07.018 id: cord-280097-f7ky61ds author: Zarogoulidis, Paul title: Are there any differences in clinical and laboratory findings on admission between H1N1 positive and negative patients with flu-like symptoms? date: 2011-01-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The World Health Organization alert for the H1N1 influenza pandemic led to the implementation of certain measures regarding admission of patients with flu-like symptoms. All these instructions were adopted by the Greek National Health System. The aim of this study was to retrospectively examine the characteristics of all subjects admitted to the Unit of Infectious Diseases with symptoms indicating H1N1 infection, and to identify any differences between H1N1 positive or negative patients. Patients from the ED (emergency department) with flu-like symptoms (sore throat, cough, rhinorhea, or nasal congestion) and fever >37.5°C were admitted in the Unit of Infectious diseases and gave pharyngeal or nasopharyngeal swabs. Swabs were tested with real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR). FINDINGS: Patients were divided into two groups. Group A comprised 33 H1N1 positive patients and Group B (control group) comprised of 27 H1N1 negative patients. The two groups did not differ in terms of patient age, co-morbidities, length of hospitalization, temperature elevation, hypoxemia, as well as renal and liver function. There were also no significant differences in severity on admission. C-reactive protein (CRP) (mean 12.8 vs. 5.74) and white blood count (WBC) (mean 10.528 vs. 7.114) were significantly higher in group B than in group A upon admission. Obesity was noted in 8 patients of Group A (mean 31.67) and 14 patients of Group B (mean 37.78). Body mass index (BMI) was lower in H1N1 positive than in H1N1 negative patients (mean 31.67 vs. 37.78, respectively; p = 0.009). CONCLUSIONS: The majority of patients in both groups were young male adults. CRP, WBC and BMI were higher among H1N1 negative patients. Finally, clinical course of patients in both groups was mild and uneventful. url: https://www.ncbi.nlm.nih.gov/pubmed/21214902/ doi: 10.1186/1756-0500-4-4 id: cord-010501-kd95xvsg author: Zenetos, Argyro title: Analysis of Benthic Communities in the Cyclades Plateau (Aegean Sea) Using Ecological and Paleoecological Data Sets date: 2008-06-28 words: 2856.0 sentences: 188.0 pages: flesch: 54.0 cache: ./cache/cord-010501-kd95xvsg.txt txt: ./txt/cord-010501-kd95xvsg.txt summary: Standard multivariate analysis techniques were applied to both ecological (living benthic fauna) and paleoecological data sets in order to distinguish distribution patterns. The species richness, abundance, and diversity per station is given in Table 2 : the number of species ranged from 21 (station A23) to 100 (station A32), and the number of specimens from 152-m-2 (station A 17) to 432.m-2 (station A26 The dendrograms can be truncated at any level, but the areal presentation derived with MDS based on the total living fauna (Fig. 4 a) indicated that the more justified separation in terms of ecological sense was at the 4 groups level (25% similarity) (two dimensional stress = 0.141). The groups are based on the dendrogram of Fig. 2 Table 5 shows the results of the SPEARMAN rank correlation coefficient between the biotic parameters (number of macrofaunal species, number of specimens, and species diversity) and depth and sediment type. abstract: Abstract. In the Cyclades plateau (Aegean Sea), a qualitative and quantitative analysis of macro‐benthic fauna was carried out in 1986. Standard multivariate analysis techniques were applied to both ecological (living benthic fauna) and paleoecological data sets in order to distinguish distribution patterns. Results showed that caution must prevail in drawing conclusions from a limited data set. The clearest classification was obtained using total living fauna, while the dead molluscan fauna gave a similar pattern; this indicates similar response to the environmental conditions of the area. In the analysis of the living molluscan fauna, the groups failed to show any clusters, probably as an effect of some impoverished sites. In the two groups delineated, depth seems to be the major factor in the distribution of species. The fact that two distinct data sets (subfossil assemblages and living communities), when treated separately, produce similar grouping indicates that the subfossil assemblages could be reliably used as a first approach for determination of the living communities' distribution patterns. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192327/ doi: 10.1111/j.1439-0485.1991.tb00247.x id: cord-303378-cfbvka30 author: Zhang, Shi-Jin title: Effect of the Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia date: 2013-08-31 words: 2936.0 sentences: 147.0 pages: flesch: 54.0 cache: ./cache/cord-303378-cfbvka30.txt txt: ./txt/cord-303378-cfbvka30.txt summary: Abstract Objective To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. Methods: A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. On the basis of related studies, we illustrated the advantages of Haoqinqingdan decoction in treating this disease and its role in regulating immunity through the comparison between the high, medium and low dose Haoqinqingdan decoction groups and the ribavirin group, which would provide basis for differential traditional Chinese medicine treatment of upper respiratory viral infection [6] . abstract: Abstract Objective To investigate the effect of Chinese medicine prescription-Haoqinqingdan decoction on damp-heat syndrome in rats with influenza viral pneumonia and its influence on the immune function. Methods A total of 48 Wistar rats were randomly divided into the normal control group, the damp-heat syndrome model group, the Haoqinqingdan decoction group (high, medium and low dose group) and the ribavirin group. The body temperature and weight of rats in each group were recorded after modeling. After treatment for 6 d, the concentration of T lymphocyte subgroup (CD3+CD4+, CD3+CD8+) was determined by flow cytometry. The OD value of IFN-γ/IL-4 was detected by double-antibody sandwich ELISA method, and its concentration was acquired through conversion. Results After modeling, the temperature and weight of rats in each modeling group showed the increasing trend (P<0.01). From the second day of treatment, there was significant difference in the body mass between groups, and the rat weight of the control group was higher than in the modeling group (P<0.05 or 0.01). With the advances of treatment, only the temperature in the medium and high dose Haoqinqingdan decoction groups declined significantly (P<0.05). After treatment, the CD4+/CD8+ ratio of the damp-heat syndrome model group decreased more significantly compared with the control group. Elevated CD3+ CD8+ percentages and declined CD4+/CD8+ ratios can be observed in the low dose group and ribavirin group (P<0.05). Moreover, the CD3+ CD4+ percentage of ribavirin group was lower than in the control group (P<0.05). After treatment, the IFN-γ and IFN-γ/ IL-4 levels in the peripheral blood of rats in the damp-heat syndrome group were obviously higher than in the control group (P<0.05). Conclusions Compared with ribavirin, the high dose Haoqinqingdan decoction can improve the ratio of T lymphocyte subgroup and Th1/Th2 cell balance more effectively. url: https://doi.org/10.1016/s1995-7645(13)60113-3 doi: 10.1016/s1995-7645(13)60113-3 id: cord-024461-xo75855r author: Zhang, Yuanzhe title: FCP Filter: A Dynamic Clustering-Prediction Framework for Customer Behavior date: 2020-04-17 words: 3883.0 sentences: 227.0 pages: flesch: 55.0 cache: ./cache/cord-024461-xo75855r.txt txt: ./txt/cord-024461-xo75855r.txt summary: In the meanwhile, Fragmentation and Coagulation Process (FCP), a stochastic partition model, has recently been proposed for identifying dynamic customer groups and modeling their purchase behavior. In our model, FCP clusters customers into groups by their temporal interests to filter random noise of individual transaction data. We conduct experiments on both synthetic and real-world datasets, demonstrating that our model is able to discover the latent group of individual customers and provides accurate predictions for dynamic purchase behavior. In order to track the customers'' temporal shifting across groups, a novel Bayesian non-parametric customer segmentation model FC-CSM [7] based on a random partition process, Fragmentation and Coagulation Process (FCP) [1] , was proposed. We conducted experiments on synthetic and real-world datasets to illustrate that our model can (1) identify dynamic customer groups based on purchase behavior, (2) achieve more accurate prediction results by filtering individual random noise. abstract: Customer purchase behavior prediction plays an important role in modern retailing, but the performance of this task is often limited by the randomness of individual historic transaction data. In the meanwhile, Fragmentation and Coagulation Process (FCP), a stochastic partition model, has recently been proposed for identifying dynamic customer groups and modeling their purchase behavior. However, FCP is not able to forecast the purchase behavior because such a data-driven method requires transaction observations to conduct clustering. To tackle this challenge, we propose FCP filter, a clustering-prediction framework based on FCP, which can forecast purchase behavior and filter random noise of individual transaction data. In our model, FCP clusters customers into groups by their temporal interests to filter random noise of individual transaction data. Then a predictor is built on grouped data. The predicted results are also fed to FCP to adjust the parameter for prior knowledge at the next time step. Our model is superior in capturing temporal dynamics and having flexible number of groups. We conduct experiments on both synthetic and real-world datasets, demonstrating that our model is able to discover the latent group of individual customers and provides accurate predictions for dynamic purchase behavior. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206192/ doi: 10.1007/978-3-030-47426-3_45 id: cord-016559-tqd7m2i1 author: Zheng, Yi title: Application in Medicine Systems date: 2014-10-28 words: 19346.0 sentences: 778.0 pages: flesch: 48.0 cache: ./cache/cord-016559-tqd7m2i1.txt txt: ./txt/cord-016559-tqd7m2i1.txt summary: Danshen has the function of effectively dilating the coronary artery, increasing coronary blood flow, reducing heart rate, inhibiting platelet aggregation and thrombopoiesis induced by platelet activation factors, promoting the recovery of injured cardiac muscle, increasing cardiac contractility, and protecting cardiac muscle cells; thus it can be widely applied in treating the diseases of the circulation system. [7] reported the application of 0.5/ 250 ml of puerarin and glucose injection combined with 16 ml of CDI in the treatment of 44 patients with coronary heart disease and angina pectoris, and the results showed that in the treatment group there were 31 patients with a marked effect, 10 patients with an effect, 3 patients without effect, and the total effective rate was 93.2 %. Patients with cerebral hemorrhage were treated with CDI, and the rates of recovery and significant improvement in the treatment group were significantly better than those in the control group, and no side effects were observed. abstract: Modern pharmacological studies on Danshen have shown that the pharmacologic actions of Danshen mainly include dilating vessels, promoting blood flow, improving microcirculation, changing blood viscosity, increasing myocardial blood and oxygen supplies, reducing myocardial consumption of oxygen, etc. The drug is used to treat diseases of the cardio-cerebrovascular system. In addition, Danshen also has antitumor, antibacterial, and anti-inflammatory functions. Therefore, Danshen has wide clinical application. In recent years, there has been an increase in the number of reports on the clinical application of Danshen extract and Danshen compound preparations. Danshen is seldom used alone; rather, it is usually combined with other drugs to form compound preparations. Various Danshen preparations have been developed, such as Compound Danshen Tablets, Compound Danshen Dropping Pill ( Dantonic™), Compound Danshen Granules, Compound Danshen Capsule, Compound Danshen Oral Liquid, Compound Danshen Aerosol, and Compound Danshen Injection (CDI), etc. The successful development of these preparations has improved product quality, enhanced efficacy, and opened up broader prospects for Danshen’s clinical application. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120891/ doi: 10.1007/978-94-017-9466-4_1 id: cord-278802-bverdk5w author: Zhou, Yefei title: Immune response of AA broilers to IBV H120 vaccine and sodium new houttuyfonate date: 2010-12-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract In this report, 120 healthy one-day-old AA broilers were divided into six groups. Groups 1–4 received 100, 200, 400 and 800mg/L of sodium new houttuyfonate (SNH) with IB vaccine H120 respectively. Group 5 received PBS and H120 and group 6 IL-2 and H120. The chickens were inoculated at 7 and 14days of age. On 0, 7, 14, 21, 28 and 35 post first vaccination, the dynamic changes of peripheral lymphocyte proliferation, cytokine assays and serum antibody titers were assayed respectively by MTT method, ELISA and hemagglutination inhibition assay (HI). The results showed that sodium new houttuyfonate significantly raised IB antibody titer in the chickens and also markedly promoted lymphocyte proliferation. The serum levels of IFN-γ and IL-4 in groups 1–4 were higher than those in groups 5 and 6. Hence, the immunologic enhancement of SNH was slightly superior to that of IL-2 adjuvant. Following challenge with IBV, chickens inoculated with SNH showed fewer and less severe clinical signs, lower death rate and less kidney pathology, as compared to those of the control groups. It indicated that SNH could enhance immune responses and increase protection against virulent IBV challenge in chickens. url: https://doi.org/10.1016/j.rvsc.2010.04.010 doi: 10.1016/j.rvsc.2010.04.010 id: cord-298534-1j8jkfn9 author: Zhu, H. title: Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study date: 2020-11-03 words: 3580.0 sentences: 205.0 pages: flesch: 63.0 cache: ./cache/cord-298534-1j8jkfn9.txt txt: ./txt/cord-298534-1j8jkfn9.txt summary: title: Features of alpha-HBDH in COVID-19 patients with different ages,outcomes and clinical types: a cohort study At present, there is no study to systematically analyse the features of hydroxybutyrate dehydrogenase (alpha-HBDH) in COVID-19 patients with different ages, clinical types and outcomes. Methods: Electronic medical records including demographics, clinical manifestation, alpha-HBDH test results and outcomes of 131 hospitalized COVID-19 patients, with confirmed result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, were extracted and analyzed. In this 46 study, we analyzed the changes of α-HBDH values of COVID-19 patients with different ages, clinical types and outcomes. The effects of α-HBDH, age and gender on the clinical type of COVID-19 patients were quantified by the optimal scale regression model, so as to 48 achieve the purpose of early judging the severity of the disease. 58 The symptom onset data was designed as the first day of disease, the abnormal percentage, median and quartile interval of α-HBDH in different 59 ages, outcomes and clinical types were calculated. abstract: Background: Coronavirus disease-2019 (COVID-19) has spread all over the world and brought extremely huge losses. At present, there is no study to systematically analyse the features of hydroxybutyrate dehydrogenase (alpha-HBDH) in COVID-19 patients with different ages, clinical types and outcomes. Methods: Electronic medical records including demographics, clinical manifestation, alpha-HBDH test results and outcomes of 131 hospitalized COVID-19 patients, with confirmed result of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral infection, were extracted and analyzed. Results: The alpha-HBDH value in greater than or equal to 61 years old group, severe group and critical group, death group all increased at first and then decreased, while no obvious changes were observed in other groups. And there were significant differences of the alpha-HBDH value among different age groups, clinical type groups and outcome groups. The optimal scale regression model showed that alpha-HBDH value and age were related to clinical type. Conclusions: alpha-HBDH value increases in some COVID-19 patients, obviously in greater than or equal to 61 years old, death and critical group, indicating that patients in these three groups suffer from more serious tissues and organs damage, higher alpha-HBDH value and risk of death. The obvious difference between death and survival group in early stage may provide a approach to judge the prognosis. The accuracy of the model to distinguish severe/critical type and other types is 85.84%, suggesting that alpha-HBDH could judge the clinical type of COVID-19 patients accurately. In brief, alpha-HBDH is an important indicator to judge the severity and prognosis of COVID-19. url: https://doi.org/10.1101/2020.10.29.20222612 doi: 10.1101/2020.10.29.20222612 id: cord-000083-3p81yr4n author: nan title: Poster Exhibition date: 2009-01-31 words: 112815.0 sentences: 7542.0 pages: flesch: 56.0 cache: ./cache/cord-000083-3p81yr4n.txt txt: ./txt/cord-000083-3p81yr4n.txt summary: R. China Background: The objective of this study was to evaluate the early virologic response for prediction of achievement of HBeAg seroconversion and hepatitis B virus (HBV) DNA negativity after two years of lamivudine treatment in chronic hepatitis B (CHB) patients. Methods: A total of 620 patients who tested positive for hepatitis B surface antigen and were referred to Chiba University Hospital between February 1985 and March 2008 were included in the study, and their following characteristics were analyzed: age, gender, the status of HBeAg, ALT, HBV-DNA level, and PLT. Methods: A total of 60 patients with chronic hepatitis B, 32 (53.3%) were HBeAg positive (group A) while 28(46.7%) were HBeAg negative (group B) were included in this study after meeting the following criteria: age 18 to 60 years, HBsAg positive for more than 6 months, serum HBV-DNA was >5 log(10) copies/mL and ALT more than two times the upper normal limit. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712310/ doi: 10.1007/s12072-009-9123-4 id: cord-000977-ka4261wc author: nan title: ECR 2013 Book of Abstracts - B - Scientific Sessions date: 2013-03-07 words: 132895.0 sentences: 8080.0 pages: flesch: 50.0 cache: ./cache/cord-000977-ka4261wc.txt txt: ./txt/cord-000977-ka4261wc.txt summary: Methods and Materials: Mean attenuation, contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR) at abdominal aorta, right renal artery (RRA) and left renal artery (LRA) were measured in 24 kidney donors who had undergone CTA with tube current modulation, 120 kVp, filtered back projection reconstruction algorithm (Group A) and were compared with 24 BMI-matched kidney donors who had undergone CTA with automated kVp selection and SAFIRE (Group B Purpose: Cerebral small vessel disease (SVD) is a common cause of cognitive impairment. Overall average score of SSF reconstructed segments was significantly higher compared with STD reconstruction ( Purpose: To evaluate the feasibility and imaging quality of double prospectively ECG-triggered high-pitch spiral acquisition mode for coronary computed tomography angiography (CTCA) in patients with atrial fibrillation (AF). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666652/ doi: 10.1007/s13244-013-0228-x id: cord-002774-tpqsjjet author: nan title: Section II: Poster Sessions date: 2017-12-01 words: 83515.0 sentences: 5162.0 pages: flesch: 54.0 cache: ./cache/cord-002774-tpqsjjet.txt txt: ./txt/cord-002774-tpqsjjet.txt summary: Results: The CHIP Framework The CHIP framework aims to improve the health and wellness of the urban communities served by St. Josephs Health Centre through four intersecting pillars: • Raising Community Voices provides an infrastructure and process that supports community stakeholder input into health care service planning, decision-making, and delivery by the hospital and across the continuum of care; • Sharing Reciprocal Capacity promotes healthy communities through the sharing of our intellectual and physical capacity with our community partners; • Cultivating Integration Initiatives facilitates vertical, horizontal, and intersectoral integration initiatives in support of community-identified needs and gaps; and • Facilitating Healthy Exchange develops best practices in community integration through community-based research, and facilitates community voice in informing public policy. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711696/ doi: 10.1093/jurban/jti137 id: cord-003532-lcgeingz author: nan title: 39th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium, 19-22 March 2019 date: 2019-03-19 words: 79997.0 sentences: 5146.0 pages: flesch: 52.0 cache: ./cache/cord-003532-lcgeingz.txt txt: ./txt/cord-003532-lcgeingz.txt summary: It''s proposed to evaluate the association between myocardial injury biomarkers, high-sensitive troponin T (hs-cTnT) and N-terminal pro-brain natriuretic peptide (NT-ProBNP), with inflammatory mediators (IL-6, IL-1Β , IL-8, IL-10, IL-12 / IL-23p40, IL17A, IL-21 and TNF-α ) and biomarkers, C protein reactive (CPR) and procalcitonin (PCT), in septic patients Methods: This was a prospective cohort study performed in three intensive care units, from September 2007 to September 2010 enrolling patients with sepsis (infection associated with organ dysfunction), and septic shock (hypotension refractory by fluids infusion requiring vasopressor). Blood samples were collected up to 48h after the development of first organ dysfunction (D0) and on the 7th day after inclusion in the study (D7) Results: Ninety-five patients were enrolled, with median age 64 years (interquatile?48-78), APACHE II: median 19 (14-22), SOFA: median 8 (5-10); 24.2% were admitted in ICU with sepsis and 75.8% with septic shock. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423782/ doi: 10.1186/s13054-019-2358-0 id: cord-005105-twsy61oq author: nan title: SIU 2015 Abstracts date: 2015-09-21 words: 124096.0 sentences: 7584.0 pages: flesch: 54.0 cache: ./cache/cord-005105-twsy61oq.txt txt: ./txt/cord-005105-twsy61oq.txt summary: Th e present study is based on a retrospective analysis of a database of over 600 patients (age range 17-57 years) who met the consensus criteria for bacterial prostatitis, 75% of whom had dysuria, 35% perineal discomfort, 60% had obstructive luts, 37% infertility of unknown etiology, 10% erectile dysfunction and 25% recurrent infection of the partner. Further research is needed to determine to assess whether localization of small volume disease on 68Ga-PSMA PET/CT can improve diagnostic algorithms and outcomes in patients with recurrent PCa. Introduction and Objective: To assess long-term results of salvage pelvic lymph node dissection (PLND) in prostate cancer (PC) patients (pts) with biochemical recurrence aft er primary local treatment and confi rmed solitary lymph node (LN) metastases. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088373/ doi: 10.1007/s00345-015-1684-3 id: cord-005453-4057qib7 author: nan title: The 45th Annual Meeting of the European Society for Blood and Marrow Transplantation: Physicians – Poster Session date: 2019-07-03 words: 275771.0 sentences: 16876.0 pages: flesch: 56.0 cache: ./cache/cord-005453-4057qib7.txt txt: ./txt/cord-005453-4057qib7.txt summary: To compare the safety and efficacy of prophylactic DLI for prevention of relapse after allogeneic peripheral blood stem cell transplantation from haploidentical donors (HID-SCT) and matched-sibling donors (MSD-SCT) in patients with very high-risk acute myeloid leukemia (AML), we performed a retrospective, observational cohort study enrolled in 21 HID-SCT and 13 MSD-SCT recipients. The aim of this study is to identify the prognostic impact of pre-transplant TIM3 levels on early and late transplant related complications as well as post-transplant relapse and survival Methods: A total of 177 hematopoietic stem cell transplantation (HSCT) recipients with an initial diagnosis of acute leukemia [median age: 36(16-66) years; male/ female: 111/66] were included in the study. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091813/ doi: 10.1038/s41409-019-0559-4 id: cord-005497-w81ysjf9 author: nan title: 40th International Symposium on Intensive Care & Emergency Medicine: Brussels, Belgium. 24-27 March 2020 date: 2020-03-24 words: 103623.0 sentences: 6176.0 pages: flesch: 53.0 cache: ./cache/cord-005497-w81ysjf9.txt txt: ./txt/cord-005497-w81ysjf9.txt summary: The positive NC group had more plasma transfusion (p-value 0.03) and a lower median hematocrit at 24 hrs (p-value 0.013), but similar hospital length of stay (p=0.17) and mortality rate (p=0.80) Conclusions: NC at ICU admission identifies subclinical AKI in TBI patients and it maight be used to predictclinical AKI. In patients with pneumonia requiring intensive care (ICU) admission, we hypothesise that abnormal right ventricular (RV) function is associated with an increased 90-day mortality. The objective of this study was to describe the incidence of each AKI stages as defined by KDIGO definition (with evaluation of urine output, serum creatinine and initiation of renal replacement therapy (RRT)), in a mixed medical and surgical population of patients hospitalized in ICU and PCU over a 10-year period (2008-2018). This study aimed at investigating the relationship of goal-directed energy and protein adequacy on clinical outcomes which includes mortality, intensive care unit(ICU) and hospital length of stay (LOS), and length of mechanical ventilation (LOMV). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7092506/ doi: 10.1186/s13054-020-2772-3 id: cord-005646-xhx9pzhj author: nan title: 2nd World Congress on Pediatric Intensive Care 1996 Rotterdam, The Netherlands, 23–26 June 1996 Abstracts of Oral Presentations, Posters and Nursing Programme date: 1996 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095092/ doi: 10.1007/bf02316512 id: cord-005727-li8pwigg author: nan title: ESICM 2010 MONDAY SESSIONS 11 October 2010 date: 2010-08-31 words: 102770.0 sentences: 6408.0 pages: flesch: 53.0 cache: ./cache/cord-005727-li8pwigg.txt txt: ./txt/cord-005727-li8pwigg.txt summary: Since, continuous epidural analgesia provides the required level of analgesia to support early mobilization and significant reduction in pulmonary and cardiovascular morbidity in the early postoperative period, we postulated that the use of low dose of continuous epidural morphine might improve postoperative analgesia and reduce undesirable side effects in elderly patientsTherefore, the present study was designed to evaluate the effects of morphine administered via epidural patients controlled analgesia and intravenous tramadol + metamizol on postoperative pain control and side effects in elderly patients after major abdominal surgery. For each ventilated patient the following data was registered:Age, APACHE II, the reason of admission, risk factors, use NIV, MV duration, timing of tracheostomy, time of diagnosis of VAP, microbiological data, length of stay and mortality in ICU. 23rd ESICM ANNUAL CONGRESS -BARCELONA, SPAIN -9-13 OCTOBER 2010 S131 Evaluated factors: patient characteristics, signs, symptoms, abscess location, time between symptoms and hospital admission and surgery, lab results, microbiology, antibiotic therapy, APACHE2, SAPS2, SOFA, length of ICU stay, surgical re-intervention, duration of mechanical ventilation, infectious complications, critical illness myopathy (CIM), renal replacement therapy (RRT), re-intubation, tracheotomy, mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095301/ doi: 10.1007/s00134-010-1999-x id: cord-005777-6rvfsx4p author: nan title: PS 0420-0716 date: 2007-08-25 words: 59217.0 sentences: 3634.0 pages: flesch: 53.0 cache: ./cache/cord-005777-6rvfsx4p.txt txt: ./txt/cord-005777-6rvfsx4p.txt summary: We prospectively recorded data of all patients who were newly diagnosed with AF and all those with a septic shock on a surgical ICU (no cardiac surgery) during a one year period according to the requirements of the local ethical committee. Our aim was to evaluate the predictive role of admission APACHE II, admission and total maximum SOFA score, hypoalbuminemia, increased serum creatinine, C-reactive protein, lactate, and serum blood glucose for the 30-day mortality of septic patients admitted to medical ICU. The aim of this study was to analyze the clinical presentation and to evaluate mortality associated factors (timing and accurancy of diagnosis, timing of surgery, severity score and organ failure, surgical and medical treatments). Data were extracted independently to assess intention to treat intensive care unit (ICU) and hospital mortality, days of mechanical ventilation, length of stay, incidence of ventilator-associated pneumonia and pneumothorax, and associated complications of the implemented intervention. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095424/ doi: 10.1007/s00134-007-0823-8 id: cord-005814-ak5pq312 author: nan title: 8th European Congress of Intensive Care Medicine Athens - Greece, October 18–22, 1995 Abstracts date: 1995 words: 179164.0 sentences: 12028.0 pages: flesch: 56.0 cache: ./cache/cord-005814-ak5pq312.txt txt: ./txt/cord-005814-ak5pq312.txt summary: Results: In 5 patients with treated SS, 16 tests were performed (VL n=8; Dobu n=4; NA n=4 Method: Septic shock was defined as severe sepsis with either persistent hypotension (mean arterial pressure; MAP<70 mmHg) or the requirement for a noradrenaline (NA) infusion ~> 0.1 ~g/kg/min with a MAP _< 90mmHg. Cardiovascular support was limited to NA + dobutamine (DB), 546C88 was administered for up to 8 h at a fixed dose-rate of either i, 2.5, 5, 10 or 20 mg/kg/h iv. Methods: Fourteen cases were s~udied,their gestational age ranged from(27-32)ws.Continnous positive air way pressure was applied to six cases at Peep level from (3-6)cm H2o through nasal pronge,(group I),the other 8 cases were managed as routine,(group II).Blood gases, TcPO2,TcCo2,resp.rate,depth and pattern were monitored for assessment of tissue Oxygenation and ventilation, Results: Our rasults showed that early application of CPAP improve ventilation among (83.3%)of cases,while (16.7%)of cases need IMV.The cases of group II need IMV among (75%)of the studied cases during the second or the third day of life. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095534/ doi: 10.1007/bf02426401 id: cord-005816-i54q5gsu author: nan title: 10(th) European Congress of Trauma and Emergency Surgery: May 13–17, 2009 Antalya, Turkey date: 2009-08-06 words: 83124.0 sentences: 5617.0 pages: flesch: 53.0 cache: ./cache/cord-005816-i54q5gsu.txt txt: ./txt/cord-005816-i54q5gsu.txt summary: Several factors such as the initial lack of symptoms, a low diagnostic sensitivity of the CT (34% false negatives), and the nonoperative management of solid organ injuries, have contributed to a delayed diagnosis in one of every five patients in our series, but this has not led to a significant increase in septic complications in this group. Method: The demographic features, the treatments, the intensity of the illness and mortality rate of the 155 patients in Afyon Kocatepe University General Surgery clinic between the years 2006 Background: Enterocutaneous fistula continues to be a serious surgical problem. Introduction: In our previous study, we examined the treatment results of burn patients older than 45 years, and found a significant increase in mortality with increasing age groups. Methods: Data on emergency surgical cases and admissions to the surgical service over a 3-month period were collected and analyzed; this included patient demographics, referral sources, diagnosis, operation, and length of stay (LOS Conclusion: Emergency workload represents a significant part of the work for the general surgeons. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095784/ doi: 10.1007/s00068-009-8001-z id: cord-005881-oswgjaxz author: nan title: Abstracts: 11(th) European Congress of Trauma and Emergency Surgery May 15–18, 2010 Brussels, Belgium date: 2010 words: 71955.0 sentences: 4561.0 pages: flesch: 52.0 cache: ./cache/cord-005881-oswgjaxz.txt txt: ./txt/cord-005881-oswgjaxz.txt summary: Prospective case series with historical control group.(Level III) Results: Preliminary data indicate: *a shorter time on ventilator than anticipated (based on comparisson to historical data) * a shorter time on ICU * less pneumoniae * no intra-operative complications * good healing results of the rib fractures * no implant failures * acceptable pain scores * good overal satisfaction * acceptable cosmetic results Conclusion: Internal fixation of rib fractures (flair chest or multiple sequential fractures with pulmonary function compromise) results in a earlier recuperation of pulmonary function with shortened ICU stay. (Regional Association Sanitary Emergencies) Material and Methods: The ARES, whose members are about 600, all over the nation, is configured as an extraordinary health resource, activated by the National Civil Defence operations centre, in according with the Regional centre of Marche, in disater situations Results: The main objectives of ARES are training and organization of medical staff and structures and its growth crosses several missions including: AE Earthquake in Molise, 2002 Introduction: Cephalomedullary nails rely on a large lag screw that provides fixation into the femoral head. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095891/ doi: 10.1007/s00068-010-8888-z id: cord-006391-esnsa4u5 author: nan title: Abstracts 5(th) Tripartite Meeting Salzburg/Austria, September 9–11,1982 date: 1982 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101735/ doi: 10.1007/bf01279099 id: cord-006849-vgjz74ts author: nan title: 27th International Congress of the European Association for Endoscopic Surgery (EAES) Sevilla, Spain, 12–15 June 2019 date: 2019-09-13 words: 222162.0 sentences: 14023.0 pages: flesch: 48.0 cache: ./cache/cord-006849-vgjz74ts.txt txt: ./txt/cord-006849-vgjz74ts.txt summary: Methods: We are performing this procedures within a prospective randomized trial that is design to compare the long term results of LRYGB-B versus the standard laparoscopic Roux-en-Y gastric bypass.The video shows our technique in a case of a 46 years old female with a BMI of 46 Kg/m2. Material and methods: We present a video of the surgical intervention of a 32-year-old patient, with functional dyspepsia, with a casual diagnosis of a pseudocystic mass of the right colon after performing a CT scan: giant diverticulum of the hepatic colon angle with fecaloid content inside it under tension The patient goes to the emergency room for acute abdominal pain, pending colonoscopy, antibiotic treatment is established, and a laparoscopic approach is decided upon after the patient''s evolution. Method: We present the case of a 65-year-old patient with surgical antecedent of laparoscopic low anterior resection due to rectal cancer, presenting in postoperative period an anastomosis leakage with severe peritonitis was identified and a laparotomy with end colostomy was performed. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103177/ doi: 10.1007/s00464-019-07109-x id: cord-006854-o2e5na78 author: nan title: Scientific Session of the 16th World Congress of Endoscopic Surgery, Jointly Hosted by Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) & Canadian Association of General Surgeons (CAGS), Seattle, Washington, USA, 11–14 April 2018: Poster Abstracts date: 2018-04-20 words: 166047.0 sentences: 10353.0 pages: flesch: 47.0 cache: ./cache/cord-006854-o2e5na78.txt txt: ./txt/cord-006854-o2e5na78.txt summary: Totally Laparoscopic ALPPS Combined with the Microwave Ablation for a Patient with a Huge HCC Hua Zhang; Department of Hepatopancreatobiliary Surgery, West China Hospital, Sichuan University Introduction: Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) is a novel technique for resecting hepatic tumors that were previously considered unresectable due to the insufficient future liver remnant (FLR) which may result in postoperative liver failure (PLF). Not only does this case show that a large epiphrenic diverticulm can be successfully resected via the trans-abdominal laparoscopic approach, this case makes the argument that patients undergoing any minimally-invasive epiphrenic diverticulectomy and myotomy, with or without fundoplication, may be successfully managed with early post-operative contrast studies and dietary advancement, thus decreasing their length of hospitalization and overall cost of treatment. Introduction: There are reports of increased operative duration, blood loss and postoperative morbidity, caused by difficulties in obtaining good visualization and in controlling bleeding when laparoscopic resection is performed in obese patients with colon cancer. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103183/ doi: 10.1007/s00464-018-6121-4 id: cord-009567-osstpum6 author: nan title: Abstracts Oral date: 2008-04-23 words: 131214.0 sentences: 7728.0 pages: flesch: 53.0 cache: ./cache/cord-009567-osstpum6.txt txt: ./txt/cord-009567-osstpum6.txt summary: Introduction: Previously, it has been demonstrated that FOXP3, a gene required for the development and function of regulatory T cells, was highly expressed in the graft during cardiac rejection, suggesting infiltration of regulatory T cells in the transplanted organ during an allogeneic response. Efficacy and safety parameters assessed at follow-up included: acute rejection; patient and graft survival; renal function, vital signs, basic lab results and immunosuppressive regimen for the patients 10 years after completion of the original study. We analyzed, for the first time, the expression of TLR4 in PBMC from kidney recipients with contrasted situations: operational tolerance and chronic immune-mediated rejection (Banff 2005), compared to patients with normal histology and stable graft function, non transplant patients with renal failure and healthy volunteers. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159651/ doi: 10.1111/j.1600-6143.2008.02254.x id: cord-009997-oecpqf1j author: nan title: 2018 ASPHO ABSTRACTS date: 2018-03-31 words: 182060.0 sentences: 10342.0 pages: flesch: 48.0 cache: ./cache/cord-009997-oecpqf1j.txt txt: ./txt/cord-009997-oecpqf1j.txt summary: Completed cranial radiation and proceeded to allogeneic stem cell transplant with unrelated cord marrow donor and is disease free at approximately day +200.Case 2: 5 year-old female diagnosed with FLT3 and MLL negative AML and completed treatment per COG AAML1031 study on the low risk arm without Bortezomib. Design/Method: This study was a retrospective chart review that included patients 3 to 23 years old with sickle cell disease type SS and S 0 followed at St. Christopher''s Hospital for Children. Background: Hydroxyurea, chronic blood transfusion, and bone marrow transplantation can reduce complications, and improve survival in sickle cell disease (SCD), but are associated with a significant decisional dilemma because of the inherent risk-benefit tradeoffs, and the lack of comparative studies. Brown University -Hasbro Children''s Hospital, Providence, Rhode Island, United States Background: Despite clinical advances in the treatment of sickle cell disease (SCD) in pediatric and young adult patients, pain remains a significant source of disease-related morbidity. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167873/ doi: 10.1002/pbc.27057 id: cord-010092-uftc8inx author: nan title: Abstract of 29th Regional Congress of the ISBT date: 2019-06-07 words: 233304.0 sentences: 13171.0 pages: flesch: 54.0 cache: ./cache/cord-010092-uftc8inx.txt txt: ./txt/cord-010092-uftc8inx.txt summary: Prospective testing of blood donations in endemic areas of the U.S. revealed 0.38% of donors were positive for Babesia DNA or antibodies (Moritz, NEJM, 2016) Aims: -To report results of ongoing Babesia clinical trial -To explain significance of Babesia as a TT infection Methods: In cobas â Babesia for use on the cobas â 6800/8800 Systems, is a qualitative polymerase chain reaction nucleic acid amplification test, developed to detect in whole blood (WB) donor samples the 4 Babesia species that cause human disease: B. In sensitivity analyses, there were two discrepant results for HIV testing, three for HCV, and five for anti-HBc. Summary/Conclusions: Elecsys â infectious disease parameters on the cobas e 801 analyser demonstrate high specificity/sensitivity for screening first-time blood donor samples, with similar clinical performance to other commercially available assays. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169345/ doi: 10.1111/vox.12792 id: cord-010980-sizuef1v author: nan title: ECTES Abstracts 2020 date: 2020-05-11 words: 132644.0 sentences: 8727.0 pages: flesch: 53.0 cache: ./cache/cord-010980-sizuef1v.txt txt: ./txt/cord-010980-sizuef1v.txt summary: We hypothesized that presentation to a PTC would yield increased mortality when subspecialty intervention was required and that this would be most pronounced at night when in-house attending coverage is absent at all state PTCs. Materials and methods: A review of the Pennsylvania Trauma Outcome Study (PTOS) database was performed to capture patients aged 12-18 who underwent any non-orthopedic trauma surgery. Traumatic subaxial cervical fractures: functional prognostic factors and survival analysis Introduction: The main goal of this study is to identify the risk factors for poor functional outcomes and to analyze the overall survival (OS) and complications rate in patients with traumatic cervical spinal cord injury (SCI) and subaxial cervical fracture (SACF) treated with open surgical fixation. After applying a multiple imputation on all the study variables, a logistic regression generalized estimating equation after adjustment for age, sex, mechanism of trauma, and the injury severity score as covariates and hospitals as a cluster assessed an association between quartile of patient volume in intensive care unit and hospital mortality. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223217/ doi: 10.1007/s00068-020-01343-y id: cord-011062-ukz4hnmy author: nan title: Poster date: 2020-03-11 words: 88313.0 sentences: 5669.0 pages: flesch: 55.0 cache: ./cache/cord-011062-ukz4hnmy.txt txt: ./txt/cord-011062-ukz4hnmy.txt summary: Ming-Yueh Chou 1,3 , Ying-Hsin Hsu 1 , Yu-Chun Wang 1 , Chih-Kuang Liang 1,3 , Li-Ning Peng 2,4 , Liang-Kung Chen 2,4 , Yu-Te Lin 1 ((1) Center for Geriatrics and Gerontology, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan; (2) Aging and Health Research Center, National Yang Ming University, Taipei, Taiwan; (3) Department of Geriatric Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan; (4) Center for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan) Background: Older people with frailty are at risk of adverse outcomes, such as falls, functional decline and mortality, and multi-domain intervention program may prevent those. Conclusion: Our study showed that a multicomponent exercise program is effective for posthospitalization patients because after 24-week intervention there were significant reductions in frailty and improving results in muscle strength and physical performance. Methods: Cross-sectional analysis of 757 communitydwelling older adults who completed multi-domain geriatric screen assessing for social vulnerability, mood, cognition, functional performance, nutrition, physical frailty (FRAIL) and sarcopenia (SARC-F). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223455/ doi: 10.14283/jfa.2020.9 id: cord-012518-ncrdwtdg author: nan title: Abstractband DOG 2020 date: 2020-08-24 words: 32627.0 sentences: 2475.0 pages: flesch: 59.0 cache: ./cache/cord-012518-ncrdwtdg.txt txt: ./txt/cord-012518-ncrdwtdg.txt summary: The improvement in tear film quality (measured by TBUT) was shown after application of trehalose/hyaluronate tear substitute for one month in both, glaucoma and control group patients with mild to moderate dry eye symptoms. Methods: For 351 eyes (275 patients) who underwent DMEK for Fuchs endothelial corneal dystrophy (FECD), donor ECD decrease as compared to preoperative donor ECD was evaluated up to four years after surgery. The present study included fundus images of 111 individuals with a mean refractive error of -9.3 ± 3.8 diopters (range:-20.8, +1.75) and an axial length of 26.8 ± 1.9 mm (range: 22.55, 30.88) Results: The disc-fovea distance increased significantly with longer axial length, with a relatively flat slope in the non-highly myopic eyes (Disc-Fovea-Distance = 24.3 × Axial Length (mm)+514) and a steeper slope in the highly myopic group (Disc-Fovea-Distance = 58.7 × Axial Length (mm)-460). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7444158/ doi: 10.1007/s00347-020-01197-0 id: cord-014516-r59usk02 author: nan title: Research Communications of the 24th ECVIM‐CA Congress date: 2015-01-10 words: 55041.0 sentences: 2919.0 pages: flesch: 51.0 cache: ./cache/cord-014516-r59usk02.txt txt: ./txt/cord-014516-r59usk02.txt summary: Serum prolactin concentration measured in 22/23 dogs at time zero, 6 weeks and 6 months was 3.35 ng/ml (range, 1.4-6.36), 3.57 ng/ml (range, 1.87-7.39) and 3.92 ng/ml (range, 2.01-12.92) and did not differ significantly in either time period when compared with time zero (P = 0.99 and P = 0.52).Altogether, results of this study failed to demonstrate a significant role of thyroid supplementation on the majority of evaluated behavioural symptoms as well as neurohormonal status of hypothyroid dogs during 6 months of therapy. The aims of the present study were (1) to describe a clinical series of recent autochtonous cases and (2) to retrospectively assess Angiostrongylus vasorum qPCR in bronchoalveolar lavage fluid (BALF) samples, collected over the last 7 years from a larger series of dogs, healthy or with other respiratory conditions, in order to investigate the past prevalence of the disease in Belgium. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4858066/ doi: 10.1111/jvim.12491 id: cord-014527-nvzfpntu author: nan title: Research Communications of the 25th ECVIM‐CA Congress date: 2015-11-09 words: 89238.0 sentences: 4996.0 pages: flesch: 52.0 cache: ./cache/cord-014527-nvzfpntu.txt txt: ./txt/cord-014527-nvzfpntu.txt summary: A negative outcome was associated with higher fecal S100A12 concentrations in CE dogs, but the response to different forms of treatment and fecal S100A12 has not been reported, and this information will be important to further evaluate the utility of fecal S100A12 as a biomarker for gastrointestinal disease. Statistical analysis was performed using non-parametric 2-or multiple-group comparisons, the likelihood ratio to evaluate the association between groups of dogs and response to treatment, and a receiver operating characteristic curve to calculate sensitivity and specificity at the optimum cut-off concentration. The objectives of this study were to describe pulmonary transit time and myocardial perfusion normalized to heart rate (nPTT and nMP, respectively), evaluated by means of contrast echocardiography, in dogs with stable stage C ACVIM myxomatous mitral valve disease (MMVD), and to assess short-term effects of pimobendan on these parameters. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4913621/ doi: 10.1111/jvim.13647 id: cord-014670-e31g8lns author: nan title: Poster Sessions 313-503 date: 2004-10-05 words: 28575.0 sentences: 1706.0 pages: flesch: 55.0 cache: ./cache/cord-014670-e31g8lns.txt txt: ./txt/cord-014670-e31g8lns.txt summary: Over a 12-month period patients who needed reintubation after successful trial of weaning and planned extubation, in a polyvalent intensive care unit (ICU) were identified.Data including clinical features (age, sex, SAPS II on admission, Glasgow Coma Score (GCS) on day of extubation, type of patient, length of intubation and mechanical ventilation (MV) before extubation, length of ICU stay (LOS), ICU and hospital mortality) were collected.Moreover we considered two parameters that asses airway patency and protection like predictors of EF:cough strength and suctioning frequency after extubation.Cough strength on command was measured with a semiobjective scale of 0 to 5 (0= weak cough, 5= strong cough). (3/23)(13.2%), pulmonary embolism(1/23)(4.3%)and severe sepsis(1/23)(4.3%).Seven of patients who received reintubation a cause of defective airway manage needed at least one suctioning every two hours; moreover the same patients and other three with alteration in neurological function had weak cough (grade 0 to 2).The LOS of EF patients was 23±24.3 days, their ICU and hospital mortality were 39.1% and 47.8%, respectively, both higher when compared with not reintubated patients.Results of logistic regression showed that SAPS II is the only independent risk-factor of reintubation (odds ratio 1.056, sig. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079826/ doi: 10.1007/s00134-004-2406-2 id: cord-014794-yppi30a0 author: nan title: 19th European Congress of Pathology, Ljubljana, Slovenia, September 6-11, 2003 date: 2003-07-31 words: 158059.0 sentences: 9041.0 pages: flesch: 44.0 cache: ./cache/cord-014794-yppi30a0.txt txt: ./txt/cord-014794-yppi30a0.txt summary: These parts were in a high percentage associated with fibrosis and lymphocyte rich areas and showed a higher mitotic activity than usual PTCs. Discussion The differences in the occurrence of TCV and TCmorphology between the presented series and previously reported cases might result from until now not clearly defined tall cell morphology as well as from similarities to PTCs, such as the oxyphilic variant, which is extremely rare in our series, and maybe also from often described squamous changes within PTCs. Due to these data it is not clear which tumor parts have relevance for prognosis and which tumors should be treated more aggressively than others. The aims of this study were to characterize the group of patients with BSOT and evaluate the significance of various molecular markers expression versus serous papillary ovarian carcinomas (SPOC) Material and methods We analyzed a total of 102 cases including: 64 cystadenoma, 10 borderline and 28 cystadenocarcinoma. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7087991/ doi: 10.1007/s00428-003-0864-5 id: cord-014996-p6q0f37c author: nan title: Posters_Monday_12 October 2009 date: 2009-08-06 words: 85190.0 sentences: 5288.0 pages: flesch: 54.0 cache: ./cache/cord-014996-p6q0f37c.txt txt: ./txt/cord-014996-p6q0f37c.txt summary: Data recorded on admission were the patient demographics with, acute physiology and chronic health evaluation II score (APACHE II), and type of admission; during intensive care stay, sepsis-related organ failure assessment score (SOFA) and clinical concomitant factors and conditions. For each severe septic patient the following data was registered: time delay, APACHE II and SOFA scores at ICU admission, diagnosis, the rate of compliance with the resucitation and management bundles, microbiological data, evolution of levels of serum lactate, empiric antibiotic therapy, length of stay and mortality in ICU. Sepsis and septic shock remain the most important causes of acute kidney injury (AKI) in critically ill patients and account for more than 50% of cases of acute renal failure (ARF) in intensive care units (ICU). There were no significant differences between the demographic data (sex, age) or the data on admission to intensive care (APACHE II score, ratio of medical to surgical patients) and duration of mechanical ventilation between the two groups. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094934/ doi: 10.1007/s00134-009-1593-2 id: cord-015021-pol2qm74 author: nan title: Third International Congress on the Immune Consequences of Trauma, Shock and Sepsis —Mechanisms and Therapeutic Approaches date: 1994 words: 162327.0 sentences: 9379.0 pages: flesch: 50.0 cache: ./cache/cord-015021-pol2qm74.txt txt: ./txt/cord-015021-pol2qm74.txt summary: It is our current understanding that LPS is responsible for many of the pathophysiological events observed during gramnegative infections and that one of the major mechanisms leading to shock and death is the LPS-induced activation of macrophages resulting in the production and release of lipid and peptide mediators, among which tumor necrosis factor seems to be the most important. However plasma IL-6 estimation revealed a statistically significant reduction at 6 hours in tanrine-treated animals compared to glycino and TW controls ( Objective: To evaluate the effects of allogeneic blood transfusion, thermal injury and bacterial garage on interteukin 4 (IL-4), tumor necrosis factor alpha (TNF) production and host mortality and to study if the administration of thymopentth (THY) could affect these events. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095072/ doi: 10.1007/bf02258437 id: cord-015024-2xzc0uc5 author: nan title: ESICM 2010 WEDNESDAY SESSIONS 13 October 2010 date: 2010-08-31 words: 84393.0 sentences: 5234.0 pages: flesch: 52.0 cache: ./cache/cord-015024-2xzc0uc5.txt txt: ./txt/cord-015024-2xzc0uc5.txt summary: We performed a prospective clinical study in a 17-bed multidisciplinary intensive care unit, including 21 patients with controlled mechanical ventilation and monitored with the Vigileo Ò monitor, for whom the decision to give fluids was taken due to the presence of circulatory, including arterial hypotension (MAP B 65 mmHg or systolic arterial pressure \90 mmHg), and preserved preload-responsiveness condition, defined as SVV C10%. The aim of this study was to compare and evaluate four severity scoring systems in intensive care unit (ICU), including APACHE II, APACHE III, SASP II and MODS in severe septic patient. A prospective observational study was performed in 16 mechanically ventilated critically ill patients (12 M, age 49 ± 17 yr, BMI 25 ± 5 kg/m 2 , ICU admission day 5 ± 3, APACHE II on study 20 ± 7; mean ± SD) and 6 healthy subjects (3 M, age 24 ± 9 year, BMI 24 ± 45 kg/m 2 ). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095088/ doi: 10.1007/s00134-010-2001-7 id: cord-015082-l629n8is author: nan title: Poster Sessions 323-461 date: 2002-08-29 words: 26569.0 sentences: 1648.0 pages: flesch: 52.0 cache: ./cache/cord-015082-l629n8is.txt txt: ./txt/cord-015082-l629n8is.txt summary: 14 patients awaiting urgent cardiac surgical re-vascularisation were studied with measurement of: spirometry; percentage increase in transfer factor from sitting to lying position (TF) as an indicator of micro-vascular lung disease; overnight oximetry on air; and 24hour holter monitoring Patients, who were reintubated on decreased indices of arterial oxygenation under MOSF progressing died in 100% cases ( NIMV is effective method in complex therapy of ARF, developing in postoperative period after cardiac surgery, that leads to significant improvement of lungs biomechanics and gases change function. In a prospective observational study we performed bedside ptO2 measurements in 8 patients with sepsis/septic shock to gain insight in ptO2 values and their dynamic changes related to the course of the illness, as well as investigating the practical applicability of tissue oxygen measurement in the ICU setting. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095316/ doi: 10.1007/s00134-002-1455-7 id: cord-015126-cyhcbk1j author: nan title: PS 0036-0344 date: 2007-08-25 words: 59175.0 sentences: 3672.0 pages: flesch: 54.0 cache: ./cache/cord-015126-cyhcbk1j.txt txt: ./txt/cord-015126-cyhcbk1j.txt summary: We compared them with ≥70 years old and an ICU stay < 30 days patients, the differences in ICU mortality, Apache II, age, gender and the necessity for renal replacement therapy (RRT) were not significant (see table) . The patients with mild form of acute pancreatitis had low mortality rate (similar to general ward population) despite positive ICU admission criteria in our case series with fifty per cent development of severe form with organ dysfunction/failure later on. Collected data:Demographics,Management prior and during ICU hospitalization (sedation, catecolamin drug use, blood product transfusion, intra-cranial pressure monitoring, neurosurgical emergency surgery etc.),CT-Scan results, Daily worst Glasgow coma scale, admission Simplified Acute Physiology Score II. This prospective interventional study performed in a surgical Intensive Care Unit of a tertiary University Hospital included 35 (21 males) mechanically ventilated and sedated patients with acute cardiovascular failure requiring cardiac output measurement (transpulmonary thermodilution technique)and a fluid challenge. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7095535/ doi: 10.1007/s00134-007-0820-y id: cord-015306-us58wwmp author: nan title: Abstracts for the IPNA Congress, 30 August - 3 September 2013, Shanghai, China date: 2013-06-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101731/ doi: 10.1007/s00467-013-2518-4 id: cord-015324-y44sfr0c author: nan title: Scientific Programme date: 2007-09-01 words: 197618.0 sentences: 12774.0 pages: flesch: 53.0 cache: ./cache/cord-015324-y44sfr0c.txt txt: ./txt/cord-015324-y44sfr0c.txt summary: In order to further validate this approach, we performed a prospective randomized open-label multicenter trial in 41 low-risk pediatric renal transplant recipients (12 f, 29 m; mean age 10.1 yrs; range, 3.4 to 17.8) on CsA (target trough level 100-200 ng/ml), MMF (1200 mg/m 2 per day) and methylprednisolone (3) (4) mg/m 2 per day), who were randomly assigned >1 year posttransplant to continue steroids or to withdraw over a period of 3 months. We evaluated MMF in 15 children with LN, 11 F/4 M, mean age: 12.4±3.9 yrs, proteinuria >3 g/day, decreased C3 and increased anti-dsDNA serum levels, normal renal function. Patients and methods: 91 children and adolescents (60 male, 31 female, mean age at transplantation 9.7±5.2 years) with stable renal function and observation period exceeding 6 months were included. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101932/ doi: 10.1007/s00467-007-0558-3 id: cord-015354-yknwveyz author: nan title: Abstracts_Poster presentations date: 2007-09-18 words: 221428.0 sentences: 13119.0 pages: flesch: 54.0 cache: ./cache/cord-015354-yknwveyz.txt txt: ./txt/cord-015354-yknwveyz.txt summary: Material and Methods: Fourteen individuals (mean age 47±19y range 21-75y; 4W, 10M; including 10 volunteers and 4 patients with angiographically proved CAD) underwent dynamic PET imaging studies (21 frames) at rest and during adenosine stress (0.14mg/kg/min for 6 min) after injection of 1100MBq of 82Rb (Discovery LS, GEMS). Methods:Twenty-nine patients (21 males,8 females;62±11 yrs) with recent AMI were studied.Within 6 days after AMI, the patients were performed Tl-201 R-RD perfusion SPECT using 4 mCi activity.CMR was carried out 5-20 minutes after 0,15 mmol/kg of iv.Gadobutrol injection.Myocardial perfusion and contrast enhancement was analyzed using a 17 segment model.Myocardial perfusion was scored in Tl-201 SPECT as follows:0=normal (70%-100% maximal myocardial activity(mma), 1= 69-50% mma, 2= 49-30% mma ,3=29-10% mma and 4=<10% mma ;Myocardial contrast enhancement on CMR images was graded as:0=no contrast enhancement, 1=hyperenhancement of 0-25% of the wall thickness(WT) 2=hyperenhancement of 26-50 % of the WT, 3=hyperenhancement of 51-75 % of WT and 4=hyperenhancement of 76-100 % of WT.In CMR the existence of microvascular obstruction(MO) was also evaluated.Total segment scores(TSS) in R,RD and CMR for each patient were calculated by summing of 17 segment score values. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103105/ doi: 10.1007/s00259-007-0544-9 id: cord-015368-a0qz4tb9 author: nan title: 48th Annual Meeting of the Austrian Society of Surgery, Graz, June 7–9, 2007 date: 2007 words: 86620.0 sentences: 6042.0 pages: flesch: 51.0 cache: ./cache/cord-015368-a0qz4tb9.txt txt: ./txt/cord-015368-a0qz4tb9.txt summary: Surgical treatment and evaluation, complications, short and long term patency of our patients were compared to interventional techniques and international literature. The aim of the study was to investigate: i) relevant and combined determinants of the development, management and outcome of a representative patient cohort (n ¼ 9.991) with acute appendicitis enrolled in a prospective unicenter study through a time period of 27 years (middle Europe), and ii) the frequency and impact of specific categories (e.g., characteristics of the medical history, clinical and intraoperative findings, complications), correlation and relative risk factors of the disease and its prognosis. From 01=1997 until 12=2006 198 TEM procedures were performed in 194 patients, 104 males, 90 females, mean age was 68.9 years (38-91), the median hospital stay was 8 days . No conversion to open technique had to be performed, no postoperative surgical complications were observed, one patient died 4 weeks postoperative due to liver failure following esophageal varices bleeding. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103188/ doi: 10.1007/s10353-007-0330-8 id: cord-015372-76xvzvdg author: nan title: National scientific medical meeting 1996 abstracts date: 1996 words: 36596.0 sentences: 2204.0 pages: flesch: 53.0 cache: ./cache/cord-015372-76xvzvdg.txt txt: ./txt/cord-015372-76xvzvdg.txt summary: One, two and five-year survival rates were examined; age at diagnosis and lesion type were extremely significant factors in relation to patient outcome. Patients'' age, sex, risk group, CDC stage, CD4 count, indication for therapy, complication rate and response to treatment are described. Fifty-eight patients (34 male, 24 female) ranging in age from 15 to 65 years (Mean + SD = 28.4 + 10.8) were included in the study. Among these 48 patients (mean age 68.0+12.7), after controlling for age and for the duration and continuity of subsequent antipsychotic treatment, increasing duration of initially untreated psychosis was associated with greater severity of negative symptoms (p<0.005) and with lower scores on the MMSE (p<0.05) but not with executive dysfunction on the EXIT (p=0.3). Conclusion Although not a population based study, care of IDDM in Ireland is almost totally hospital clinic based Cigarette smoking is identified as the major problem to be addressed Patients with diabetes meltitus (DM) are at a higher risk of developing vascular complications, including coronary artery disease (CAD). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7103226/ doi: 10.1007/bf02945204 id: cord-019347-tj3ye1mx author: nan title: ABSTRACT BOOK date: 2010-02-19 words: 107926.0 sentences: 6940.0 pages: flesch: 53.0 cache: ./cache/cord-019347-tj3ye1mx.txt txt: ./txt/cord-019347-tj3ye1mx.txt summary: Method:Case Report:A 15y/o w/f athlete presented with a two month history of recurrent hives and angioedema which she associated with ingestion of Halloween candy .One week before evaluation she had hives with Coconut as well.Her history was othewise unremarkable except for recurrent UTI''S, annual sinusitis, pneumonia in 1998 as well as migraines.She denied sexual activity.Her physical exam was normal.Results:An evaluation for autoimmune disease revealed normal ESR, ANA, DSDNA, mono and hepatitis serology as well as lyme titers however her CH50 was low17u/ml(normal 26-58U/ml)and evaluation of complement revealed c4 14mg/dl(normal 16-47mg//dl)and c2 <1.3mg/dl(normal 1.6-3.5mg/dl)with normal c3, c5-c9.Her father had nor-malc4 but c2 was 1.4mg/dl (normal 1.6-3.5mg/dl)Her sister had c2 of 1.5mg/dl and normal c4 and her mother had normal c2 and c4.Her workup included positive prick skin test to ragweed, ash and grass and she was started on Rhinocort and Clarinex seasonally.She has been followed for one year with resolution of hives and is asymptomatic.Her diagnosis had been confirmed by a pediatric rheumatologist.Conclusion;We present an atypical case of C2 complement deficiency in an currently asymptomatic individual. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129269/ doi: 10.1016/s1081-1206(10)61294-x id: cord-022633-fr55uod6 author: nan title: SAEM Abstracts, Plenary Session date: 2012-04-26 words: 147405.0 sentences: 8927.0 pages: flesch: 54.0 cache: ./cache/cord-022633-fr55uod6.txt txt: ./txt/cord-022633-fr55uod6.txt summary: Staff satisfaction was evaluated through pre/ post-shift and study surveys; administrative data (physician initial assessment (PIA), length of stay (LOS), patients leaving without being seen (LWBS) and against medical advice [LAMA] ) were collected from an electronic, real-time ED information system. Communication Background: The link between extended shift lengths, sleepiness, and occupational injury or illness has been shown, in other health care populations, to be an important and preventable public health concern but heretofore has not been fully described in emergency medical services (EMS Objectives: To assess the effect of an ED-based computer screening and referral intervention for IPV victims and to determine what characteristics resulted in a positive change in their safety. Objectives: Using data from longitudinal surveys by the American Board of Emergency Medicine, the primary objective of this study was to evaluate if resident self-assessments of performance in required competencies improve over the course of graduate medical training and in the years following. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159364/ doi: 10.1111/j.1553-2712.2012.01332.x id: cord-022650-phsr10jp author: nan title: Abstracts TPS date: 2018-08-14 words: 119675.0 sentences: 7010.0 pages: flesch: 55.0 cache: ./cache/cord-022650-phsr10jp.txt txt: ./txt/cord-022650-phsr10jp.txt summary: 0685 | Skin prick test reactivity to aeroallergens in adult allergy clinic in a tertiary hospital: a 12-year retrospective study Results: Five different human sera were screened for specific IgE level against 29 different allergen sources using test methods of three different suppliers. Conclusion: This multicenter prospective study confirmed that stepwise single-dose OFC to egg will help to clarify the severity of egg allergy, and will contribute to improved food allergy manageMethod: The study design was a retrospective cohort study extracting data from the electronic chart of children older than 4 years who visited our out-patient clinic for egg or milk allergy and who underwent an oral food challenge test (OFC) twice within 24 months between November 2013 and December 2017. Results: In the base case analysis, using Italy clinical practice patients with moderate-to severe allergic rhino-conjunctivitis (SS ranging from 6 to 15 points) and a mean age at entry of 21 years, both SCIT and SLIT were associated with increased cost but superior efficacy compared to pharmacotherapy alone. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159469/ doi: 10.1111/all.13539 id: cord-022653-qa1uph35 author: nan title: Poster Discussion Session PDS date: 2017-08-30 words: 58292.0 sentences: 3300.0 pages: flesch: 53.0 cache: ./cache/cord-022653-qa1uph35.txt txt: ./txt/cord-022653-qa1uph35.txt summary: 0206 | G protein coupled receptor kinase 2 (GRK2) regulates endothelial permeability induced by Bradykinin 0208 | Pharmacokinetics (PK) and pharmacodynamics (PD) of c1 esterase inhibitor of chronic urticaria challenges most commonly identified were the following: time of onset of disease; frequency/duration of and provoking factors for wheals; diurnal variation; occurrence in relation to weekends, holidays, and foreign travel; shape, size, and distribution of wheals; associated angioedema; associated subjective symptoms of lesions; family and personal history regarding urticaria, atopy; previous or current allergies, infections, internal diseases, or other possible causes; psychosomatic and psychiatric diseases; surgical implantations and events during surgery; gastric/ intestinal problems; induction by physical agents or exercise; use of drugs; food allergies; relationship to the menstrual cycle; smoking habits; type of work, hobbies; stress; quality of life and emotional impact; previous therapy and response to therapy, and previous diagnostic procedures/results. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159476/ doi: 10.1111/all.13251 id: cord-022940-atbjwpo5 author: nan title: Poster Sessions date: 2016-09-07 words: 241182.0 sentences: 12746.0 pages: flesch: 47.0 cache: ./cache/cord-022940-atbjwpo5.txt txt: ./txt/cord-022940-atbjwpo5.txt summary: We have studied the effect of inhibition of IRE1 (inositol requiring enzyme 1), which is a central mediator of endoplasmic reticulum stress and controls cell proliferation and tumor growth, on hypoxic regulation of the expression of different proliferation related genes in U87 glioma cells. Transient inhibition of Akt and mTOR protein kinase activation in tumor cells followed by reactivation of signaling pathway did not result in a time-dependent difference on EGFR, HER2 and HER3 expression levels. In our study we aimed to determine cytotoxic effect of RES in K562 human CML cell line and to evaluate the expressions of miRNAs that are associated with genetics of leukemia after treatment with RES; to investigate target genes of miRNAs which show significant expression alterations and molecular mechanisms of RES treatment. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164006/ doi: 10.1111/febs.13808 id: cord-023017-k6edtg58 author: nan title: AASLD Abstracts (pp. 282A–382A) date: 2006-02-10 words: 65796.0 sentences: 3553.0 pages: flesch: 51.0 cache: ./cache/cord-023017-k6edtg58.txt txt: ./txt/cord-023017-k6edtg58.txt summary: 14/55 (25%) patients in AC who did not discontinue by week 24 received ribavirin dose reduction in comparison to 31/108 ( The clinical outcome in response to combination therapy for treatment of chronic hepatitis C virus (HCV) infection appears to be different for Caucasian versus African American patients. Over the period of combination therapy, most patients in which serum virus titers were reduced to non detectable levels had significant increases in T cell responses to HCV proteins. CHRONIC Background: Recent large prospective trials demonstrated that the combination therapy of interferon (1FN)-alphalribavirin significantly increased the ratio of a sustained virological response in patients with chronic hepatitis C in comparison with IFN monotherapy, especially in patients with high HCV-RNA titer and genotype lb. Results: Patients with chronic HCV infection showed higher MxA gene expression levels than healthy controls, indicating that hepatitis C virus induces IFN production. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165819/ doi: 10.1002/hep.1840380505 id: cord-023095-4dannjjm author: nan title: Research Abstract Program of the 2011 ACVIM Forum Denver, Colorado, June 15–18, 2011 date: 2011-05-03 words: 134226.0 sentences: 6834.0 pages: flesch: 51.0 cache: ./cache/cord-023095-4dannjjm.txt txt: ./txt/cord-023095-4dannjjm.txt summary: The purpose of this study was to determine the short-term effects of ivabradine on heart rate (HR), blood pressure, left ventricular (LV) systolic and diastolic function, left atrial (LA) performance, and clinical tolerance in healthy cats after repeated oral doses. The goal of this study was to investigate the relationship between heart rate and ECG time intervals to body mass in apparently healthy horses and ponies and to calculate normal ranges for different weight groups. This study aimed to investigate the prevalence of hypercoagulability in PLN dogs based on thromboelastography (TEG), and to determine whether hypercoagulability in these patients could be predicted by clinical assessments that identify systemic hypertension (systolic blood pressure 4 160 mmHg), hypoalbuminemia (serum albumin o 2.7 mg/dl), antithrombin activity (o 70%), and degree of proteinuria (urine protein:creatinine ratio [UPC] ! abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166756/ doi: 10.1111/j.1939-1676.2011.0726.x id: cord-023134-y665agnh author: nan title: Oral Research Communications of the 22(nd) ECVIM‐CA Congress date: 2012-11-20 words: 29595.0 sentences: 1548.0 pages: flesch: 50.0 cache: ./cache/cord-023134-y665agnh.txt txt: ./txt/cord-023134-y665agnh.txt summary: Doppler echocardiographic indices of diastolic function of the right ventricle are good prognostic markers during left ventricular (LV) failure secondary to ischemic and dilated cardiomyopathy.The aims of the present study were: to assess LV and RV diastolic function by conventional Doppler and pulsed-wave tissue Doppler imaging (PW-TDI) in dogs with mitral valve disease (MVD), with or without pulmonary hypertension (PH); to test if echocardiographic parameters of LV and RV diastolic dysfunction correlate to the Doppler-estimated pulmonary artery systolic pressure (PASP).114 dogs were prospectively evaluated, including 86 dogs with MVD. The aims of the present study were to assess whether diabetic cats have pathological evidence of islet inflammation or pancreatitis and to define islet lesions in comparison to a well-matched control population.Formalin-fixed, paraffin-embedded pancreatic samples were collected from post-mortem examination performed on diabetic and control cats died due to any disease at the Clinic for Small Animal Internal Medicine, University of Zurich (Switzerland) between 1997 and 2009. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167033/ doi: 10.1111/jvim.12000 id: cord-023157-0lqlx2rv author: nan title: Poster Sessions date: 2013-04-18 words: 128430.0 sentences: 7726.0 pages: flesch: 55.0 cache: ./cache/cord-023157-0lqlx2rv.txt txt: ./txt/cord-023157-0lqlx2rv.txt summary: The patients revealed the increase of free fatty acids level (2.19 AE 0.10) mmol/l/ml, that meaningfully differed from such indexes in the control group (P < 0.001) and low level of adiponektin (3.70 AE 0.70) mg/ml that confirms their role in development of NAFLD even for persons with normal body weight after the presence of abdominal type of adipose tissue distribution. Results: This study has shown effectiveness in reduction in fasting blood glucose (P < 0.01), systolic blood pressure (P = 0.03), diastolic blood pressure (P = 0.01), weight (P = 0.03), added sugar (P = 0.03) and fat consumption (P < 0.01) while improving physical activity (P < 0.01) and insulin sensitivity (P < 0.01) in the intervention group when compared with the control group at follow up assessment. Conclusion: Our study shows that infiltration of macrophages in human adipose tissue, estimated by the expression of macrophage markers, is increased in subjects with obesity and diabetes and associated with insulin sensitivity and serum lipid levels independent of BMI. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167176/ doi: 10.1111/1753-0407.12032_1 id: cord-023186-gqltd6u0 author: nan title: Poster Sessions date: 2019-06-27 words: 14365.0 sentences: 814.0 pages: flesch: 55.0 cache: ./cache/cord-023186-gqltd6u0.txt txt: ./txt/cord-023186-gqltd6u0.txt summary: Methods: This is a one-year retrospective study that was conducted in our pediatric intensive care unit (PICU) comparing the intervention failure rate of three different Noninvasive respiratory support modalities (bi-level positive airway pressure (BIPAP), continuous positive airway pressure (CPAP) and HFNC) for infants and young children between the ages of 1 month and 2 years admitted with the diagnosis of bronchiolitis. The aim of the study was to determine the association between Methods: Ninety children aged between > 28 days to < 5 years hospitalized with diagnosis of severe CAP in the Pediatric Department of West Nusa Tenggara Province General Hospital from January to October 2018 were enrolled. Arterial blood gases, respiratory rate, peak inspiratory pressure (PIP) and mean airway pressure (MAP) of rat lung during respiratory support, wetto-dry lung weight ratio, lung homogenate and/or bronchoalveolar lavage fluid tumor necrosis factor-α, macrophage inflammatory protein-2, interleukin-6 and total protein levels were measured and compared among groups after study completion. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167664/ doi: 10.1002/ppul.24373 id: cord-023225-5quigar4 author: nan title: Posters date: 2012-08-21 words: 70251.0 sentences: 3367.0 pages: flesch: 43.0 cache: ./cache/cord-023225-5quigar4.txt txt: ./txt/cord-023225-5quigar4.txt summary: To further explore the structure-function relationship, a viable synthesis strategy for pseudodesmin A analogues was developed, based on side-chain attachment of the first amino acid to the solid support, followed by stepwise Fmoc solid-phase synthesis of the linear peptide precursor and on-resin head-to-tail cyclization. The cases when the amino acid sequence of a fragment coincided with part of the primary structure of a natural oligopeptide were recorded in the Total protein chemical synthesis requires a case by case design and optimization which is governed by factors such as the solubility of the individual peptide segments, their primary sequence and in particular the presence of "difficult" amino acid residues at ligation junctions such as proline or the location of cysteines. In this study we present synthesis of two series of peptide libraries, which were designed by substitution of Leu in the P5, P6 position of our control peptide (Ac-LLLLRVKR-AMBA) with each of nineteen amino acid residues in order to verifying its influence on activity and selectivity of the resulting analogues. abstract: No abstract is available for this article. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167970/ doi: 10.1002/psc.2449 id: cord-023311-7wqdlha4 author: nan title: Oral Session date: 2010-11-24 words: 17248.0 sentences: 956.0 pages: flesch: 51.0 cache: ./cache/cord-023311-7wqdlha4.txt txt: ./txt/cord-023311-7wqdlha4.txt summary: Methods We determined the usefulness of preoperative lung function by spirometry in predicting regression of pulmonary hypertension after surgical correction of mitral stenosis among 20 patients who underwent mitral valve surgery at Philippine Heart Center from July to December 2009. Elderly patients exhibited a signifi cantly higher mortality rate that was independently associated with the following: age; residence status; confusion, urea, respiratory frequency and blood pressure (CURB) score; comorbid conditions; and failure of initial therapy. Methods A total of 40 patients (Male: 50%; Female: 50%) admitted and diagnosed with HAP at our Center were followed up to investigate the rate of adherence of physicians on the diagnosis and treatment of HAP based on Level I and II ATS/IDSA 2008 recommendations and to determine its association with outcome (mortality, mechanical ventilation, ICU stay, hospital stay). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169143/ doi: 10.1111/j.1440-1843.2010.01864.x id: cord-023346-8sqbqjm1 author: nan title: MONDAY: POSTERS date: 2005-06-08 words: 130043.0 sentences: 7330.0 pages: flesch: 54.0 cache: ./cache/cord-023346-8sqbqjm1.txt txt: ./txt/cord-023346-8sqbqjm1.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169255/ doi: 10.1111/j.1423-0410.2005.00652.x id: cord-023354-f2ciho6o author: nan title: TUESDAY PLENARY SESSION 3 TUESDAY: POSTERS date: 2005-06-08 words: 130046.0 sentences: 7333.0 pages: flesch: 54.0 cache: ./cache/cord-023354-f2ciho6o.txt txt: ./txt/cord-023354-f2ciho6o.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169300/ doi: 10.1111/j.1423-0410.2005.00654.x id: cord-023364-ut56gczm author: nan title: EDUCATION DAY MONDAY: PLENARY SESSION 1 MONDAY: PARALLEL SESSIONS date: 2005-06-08 words: 130049.0 sentences: 7334.0 pages: flesch: 54.0 cache: ./cache/cord-023364-ut56gczm.txt txt: ./txt/cord-023364-ut56gczm.txt summary: • enhancement of automation/computerisation; • process control to provide an ''error-free pathway''; • (national) surveillance and trend analysis of results, preferably based on national working standards; • significantly increased sensitivity, especially from development of antigen/antibody ''combi'' assays (e.g. for HIV, and recently, for HCV); • awareness of HBsAg vaccine-escape mutants and design of assays to cope with this; • extension of range of agents and markers tested for (varies in different countries); • increasing range of assays available for testing donors with a relevant history of exposure to malaria or Chagas'' disease infection (for retrieval of otherwise wasted blood); • European Union''s in vitro diagnostics directive: this has caused some problems and reduced flexibility. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169338/ doi: 10.1111/j.1423-0410.2005.00651.x id: cord-286479-p9d78t6v author: nan title: NeoCORE Conference Abstracts date: 2020-07-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1007/s12098-020-03376-y doi: 10.1007/s12098-020-03376-y id: cord-318248-y2vkpuv3 author: nan title: Global Initiative for Chronic Obstructive Lung Disease strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease: An Asia–Pacific perspective date: 2005-02-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract: Chronic obstructive pulmonary disease (COPD) is a major public health problem and its prevalence and mortality are increasing throughout the world, including the Asia–Pacific region. To arrest these worldwide trends, the Global Initiative for Chronic Obstructive Lung Disease (GOLD) Expert Panel's global strategy for the diagnosis, management, and prevention of COPD was published in 2001. Based on recently published clinical trials, the GOLD statement was updated in 2003. The Asia–Pacific COPD Roundtable Group, a taskforce of expert respirologists from the Asia–Pacific region, has recently formulated a consensus statement on implementation of the GOLD strategy for COPD in the Asia–Pacific region. The key issues identified by the COPD Roundtable Group for comment are: (i) where there is no access to spirometry, diagnosis of COPD could be suspected on the basis of history, symptoms and physical signs; (ii) inhaled bronchodilators are the preferred regular treatment for COPD in the region, but oral bronchodilators may be considered if the cost of inhaled bronchodilators is a barrier to treatment; (iii) the use of an Metered Dose Inhaler with spacer in place of a nebulizer is recommended in the treatment of acute airflow obstruction in patients with COPD; (iv) influenza vaccination is recommended for all patients with COPD in communities where there is a high likelihood of Severe Acute Respitory Syndrome; and (v) simplified pulmonary rehabilitation programmes should be established in areas where comprehensive programmes are unavailable. Physical exercise training and education on smoking cessation should be core elements of any rehabilitation program. In summary, the COPD Roundtable Group supports implementation of the GOLD strategy for the diagnosis, management and prevention of COPD in the Asia–Pacific region, subject to the additions and modifications to the guidelines suggested above. url: https://www.ncbi.nlm.nih.gov/pubmed/15691232/ doi: 10.1111/j.1440-1843.2005.00692.x id: cord-335975-m6lkrehi author: nan title: Proceedings of Réanimation 2018, the French Intensive Care Society International Congress date: 2018-02-05 words: 89374.0 sentences: 5327.0 pages: flesch: 52.0 cache: ./cache/cord-335975-m6lkrehi.txt txt: ./txt/cord-335975-m6lkrehi.txt summary: A qSOFA score relying on 3 simple clinical criteria (respiratory rate, mental status and systolic blood pressure) has been proposed to better identify septic patients with associated higher mortality outside the intensive care unit (Seymour CW et al., JAMA 2016) . We propose to determine whether the arterial oxygen pressure (PaO2) at intensive care unit (ICU) admission affects mortality at day 28 (D28) in patients with septic shock subjected to mechanical out-of-hospital ventilation. Conclusion: In this study, we report a significant association between hyperoxemia at ICU admission and mortality at D28 in patients with septic shock subjected to pre-hospital invasive mechanical ventilation. The aim of this study was to describe outcome of pediatric patient with hematologic disease hospitalized in our intensive care unit for respiratory failure and to investigate the clinical variables associated with mortality. abstract: nan url: https://doi.org/10.1186/s13613-017-0345-7 doi: 10.1186/s13613-017-0345-7 id: cord-341063-3rqnu5bu author: nan title: 38th International Symposium on Intensive Care and Emergency Medicine: Brussels, Belgium. 20-23 March 2018 date: 2018-03-29 words: 98602.0 sentences: 6494.0 pages: flesch: 52.0 cache: ./cache/cord-341063-3rqnu5bu.txt txt: ./txt/cord-341063-3rqnu5bu.txt summary: Procacitonin (PCT) emerges as a possible predictive tool in cardiothoracic intensive care unit (CTICU).We aim at testing the predictive power of PCT for early morbidity, prolonged ventilation, ICU and hospital stay, in patients developing early fever after cardiac surgery Methods: A retrospective descriptive study done in tertiary cardiac center, enrolling patients who stayed for more than 24 hours post-operatively in the CTICU Risk stratification included additive Euro score and PCT immunoluminometricaly prior to surgery and every 48 hours in response to onset of fever. Prognostic accuracy of quick sequential organ failure assessment (qSOFA) score for mortality: systematic review and meta-analysis Introduction: The purpose of this study was to summarize the evidence assessing the qSOFA [1] , calculated in admission of the patient in emergency department (ED) or intensive care unit (ICU), as a predictor of mortality. abstract: nan url: https://doi.org/10.1186/s13054-018-1973-5 doi: 10.1186/s13054-018-1973-5 id: cord-355038-o2hr5mox author: nan title: Proceedings of Réanimation 2020, the French Intensive Care Society International Congress date: 2020-02-11 words: 102485.0 sentences: 7028.0 pages: flesch: 52.0 cache: ./cache/cord-355038-o2hr5mox.txt txt: ./txt/cord-355038-o2hr5mox.txt summary: Conclusion: In patients with moderate-to-severe ARDS, a higher tidal volume under PSV within the 72 h following neuromuscular blockers cessation is independently associated with the 28-day mortality.Compliance with ethics regulations: Yes. Kaplan-Meier estimate of the cumulative probability of survival according to the mean tidal volume (Vt)-lower of higher than 8 ml/ kg-under pressure support ventilation (PSV) during the "transition period" transfusion is associated with adverse events, and equipoise remains on the optimal transfusion strategy in oncologic patients in surgical setting. Compliance with ethics regulations: Yes. Patients and methods: In a retrospective monocentric study (01/2013-01/2017) conducted in cardio-vascular surgical intensive care unit (ICU) in Henri Mondor teaching hospital, all consecutive adult patients who underwent peripheral VA-ECMO were included, with exclusion of those dying in the first 24 h. Compliance with ethics regulations: Yes. Rationale: Acute respiratory failure is the leading reason for intensive care unit (ICU) admission in immunocompromised patients and the need for invasive mechanical ventilation has become a major clinical end-point in randomized controlled trials (RCT). abstract: nan url: https://www.ncbi.nlm.nih.gov/pubmed/32048060/ doi: 10.1186/s13613-020-0623-7 id: cord-302305-xr067v2n author: van Aalst, Jan title: Distinguishing knowledge-sharing, knowledge-construction, and knowledge-creation discourses date: 2009-06-20 words: 12911.0 sentences: 548.0 pages: flesch: 49.0 cache: ./cache/cord-302305-xr067v2n.txt txt: ./txt/cord-302305-xr067v2n.txt summary: Knowledge construction involves a range of cognitive processes, including the use of explanation-seeking questions and problems, interpreting and evaluating new information, sharing, critiquing, and testing ideas at different levels (e.g., conjectures versus explanations that refer to concepts and/or causal mechanisms), and efforts to rise above current levels of explanation, including summarization, synthesis, and the creation of new concepts. Important progress has been made in this direction by the development of a system of principles that describe the socio-cognitive and socio-technological dynamics of knowledge creation, including collective cognitive responsibility for knowledge advancement, real ideas/authentic problems, epistemic agency, improvable ideas, rise-above, and constructive use of authoritative sources (Scardamalia 2002) . However, more work is needed to characterize the innovation ecology, such as by determining the social practices that make collaboration possible, the overall school culture, and the community''s experience at knowledge creation and its long-term goals (Bielaczyc 2006; Truong 2008) . abstract: The study reported here sought to obtain the clear articulation of asynchronous computer-mediated discourse needed for Carl Bereiter and Marlene Scardamalia’s knowledge-creation model. Distinctions were set up between three modes of discourse: knowledge sharing, knowledge construction, and knowledge creation. These were applied to the asynchronous online discourses of four groups of secondary school students (40 students in total) who studied aspects of an outbreak of Severe Acute Respiratory Syndrome (SARS) and related topics. The participants completed a pretest of relevant knowledge and a collaborative summary note in Knowledge Forum, in which they self-assessed their collective knowledge advances. A coding scheme was then developed and applied to the group discourses to obtain a possible explanation of the between-group differences in the performance of the summary notes and examine the discourses as examples of the three modes. The findings indicate that the group with the best summary note was involved in a threshold knowledge-creation discourse. Of the other groups, one engaged in a knowledge-sharing discourse and the discourses of other two groups were hybrids of all three modes. Several strategies for cultivating knowledge-creation discourse are proposed. url: https://doi.org/10.1007/s11412-009-9069-5 doi: 10.1007/s11412-009-9069-5 id: cord-317347-by8albr9 author: van Ginkel, Frederik W. title: Age-dependent immune responses and immune protection after avian coronavirus vaccination date: 2015-05-28 words: 5792.0 sentences: 288.0 pages: flesch: 53.0 cache: ./cache/cord-317347-by8albr9.txt txt: ./txt/cord-317347-by8albr9.txt summary: The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. Therefore, the ability of SPF chickens of different age to induce an IBV-specific antibody response and protect against challenge with an IBV field strain was measured. In order to measure IgG (IgY), IgA and IgM antibody levels in plasma and tears of chicken, an IBV-specific enzyme-linked immunosorbent assay (ELISA) was developed as previously described [20] . These data are consistent with a delay in the IgA plasma response to IBV in birds vaccinated at a younger age and a non-significant decline in mean IgA titers in the 1-day-old group. This would be consistent with a drop of presumably natural maternal IBV-specific IgM antibodies in these SPF chickens in the day 7 control age group. abstract: Infectious bronchitis virus (IBV) is an endemic disease of chickens and a major contributor to economic losses for the poultry industry despite vaccination. Recent observations indicated that chicks may have an immature immune system immediately after hatching when vaccinated for IBV. Therefore we hypothesized that early IBV vaccination will generate an immature, poorly protective IBV-specific immune response contributing to immune escape and persistence of IBV. To test this hypothesis the IBV-specific immune response and immune protection were measured in chicks vaccinated at different ages. This demonstrated a delayed production of IgG and IgA plasma antibodies in the 1, 7 and 14-day-old vaccination groups and also lower IgA antibody levels were observed in plasma of the 1-day-old group. Similar observations were made for antibodies in tears. In addition, IgG antibodies from the 1-day-old group had lower avidity indices than day 28 vaccinated birds. The delayed and/or lower antibody response combined with lower IgG avidity indices coincided with increased tracheal inflammation and depletion of tracheal epithelia cells and goblet cells upon IBV field strain challenge. The lack of vaccine-mediated protection was most pronounced in the 1-day-old vaccination group and to a lesser extent the 7-day-old group, while the 14-day-old and older chickens were protected. These data strongly support IBV vaccination after day 7 post hatch. url: https://api.elsevier.com/content/article/pii/S0264410X1500479X doi: 10.1016/j.vaccine.2015.04.026 ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel