id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002706-m3y35ozx	Guo, Fang	HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways	2017-09-25		.txt	text/plain	7399	351	42	Interestingly, in addition to inhibiting nucleocapsid assembly and subsequent viral genome replication, we have now demonstrated that HAPs and SBAs differentially modulate the biosynthesis of covalently closed circular (ccc) DNA from de novo infection and intracellular amplification pathways by inducing disassembly of nucleocapsids derived from virions as well as double-stranded DNA-containing progeny nucleocapsids in the cytoplasm. Inspired by the observation that a small molecule compound targeting the capsid protein of dengue virus has dual effects on both the assembly and disassembly (or uncoating) of the viral capsids [22] , we hypothesized that HBV CpAMs may not only disrupt capsid assembly, but also alter the structure and function of assembled nucleocapsids and consequentially affect viral DNA replication and/or cccDNA synthesis.	./cache/cord-002706-m3y35ozx.txt	./txt/cord-002706-m3y35ozx.txt