id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-028530-hpgrbhkl	Cairoli, Ernesto	Hydroxychloroquine in the treatment of COVID-19: how to use it waiting for conclusive scientific evidence()	2020-07-04		.txt	text/plain	852	59	54	Hydroxychloroquine in the treatment of COVID-19: how to use it waiting for conclusive scientific evidence Autores: Ernesto Cairoli MD, PhD a, b , Gerard Espinosa MD, PhD c . In the COVID-19 patient, possible cardiac involvement is mainly related to 4 factors: 1) underlying heart disease (often silent in older patients); 2) myocardial involvement caused by the infection and the inflammatory response itself, which leads to myocarditis with elevated troponins; 3) acute toxicity probably associated with the use of antimalarials in high doses, more evident in chloroquine treatments and 4) concomitant use of other treatments that, together with HCQ, prolong the corrected QT interval (QTc), with the risk of serious ventricular arrhythmias 3-5 . -Pending the result of several active studies, HCQ should not be indicated prophylactically as there is no evidence to support its preventive use or postexposure to avoid COVID-19 infection.	./cache/cord-028530-hpgrbhkl.txt	./txt/cord-028530-hpgrbhkl.txt