id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259663-fjvumaby	Carvalho, Alzira Alves de Siqueira	Side Effects of Chloroquine and Hydroxychloroquine on Skeletal Muscle: a Narrative Review	2020-10-31		.txt	text/plain	2738	155	48	PURPOSE OF REVIEW: Concerning adverse neuromuscular effects, there are quite a few reports about the incidence and prevalence of chloroquine (CQ) and hydroxychloroquine (HCQ) myopathy. Currently, emerging therapies and repurposing of old drugs have been considered therapeutic strategies, including chloroquine (CQ) and hydroxychloroquine (HCQ) [1, 2] , both drugs showing activity against COVID-19 in vitro [3] ; however, the level of preclinical and clinical data is not strong and must be approved by a higher level of evidence [4, 5] . The rimmed vacuolar changes found in muscle have been considered the most representative aspect in muscle biopsies of patients with myopathy induced by antimalarials; however, the absence of these vacuoles in some cases does not exclude the diagnosis [25] . By contrast, Kalajian and Callen [55] did not find an association between elevated serum muscle enzymes and underlying antimalarial-induced myopathy in patients taking CQ or HCQ.	./cache/cord-259663-fjvumaby.txt	./txt/cord-259663-fjvumaby.txt