id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270290-i4p4p0o4	Ruamviboonsuk, Paisan	Chloroquine and Hydroxychloroquine Retinal Toxicity Consideration in the Treatment of COVID-19	2020-04-29		.txt	text/plain	1716	91	54	The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. [6] [7] [8] [9] [10] [11] As the therapeutic doses of CQ and HCQ recommended in the trials and guidelines are relatively high compared with the maximum daily safe dose that is related to CQ and HCQ retinal toxicity, this issue of retinal toxicity should be taken into consideration when employing these 2 medications for treatment of COVID-19 worldwide. According to the recommendation by the American Academy of Ophthalmology, the most significant major risk factors for CQ and HCQ retinal toxicity are high dose and long duration of use.	./cache/cord-270290-i4p4p0o4.txt	./txt/cord-270290-i4p4p0o4.txt