id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-272296-1gn1zhvt	HUYBRECHTS, Krista F.	Hydroxychloroquine early in Pregnancy and Risk of Birth Defects	2020-09-19		.txt	text/plain	4618	227	47	We compared the risk of congenital malformations in women with HCQ use during the first trimester versus no use, restricting the cohort to women with rheumatic disorders and using propensity score matching to control for indication, demographics, medical comorbidities, and concomitant medications (N= 1,867 HCQ exposed; 19,080 unexposed pregnancies). [10] [11] [12] [13] However, data 134 regarding the risk of major congenital malformations associated with early pregnancy exposure 135 is very limited, with the largest published cohort study including fewer than 200 exposed 136 pregnancies (Supplementary Table 1 ). Utilizing data from health plans that provide coverage for large populations of both commercially 250 and publicly insured individuals in the US, we identified a cohort of pregnant women with 251 chronic autoimmune rheumatic diseases and assessed the relative prevalence of major 252 congenital malformations in their newborns following exposure to HCQ during early pregnancy.	./cache/cord-272296-1gn1zhvt.txt	./txt/cord-272296-1gn1zhvt.txt