id sid tid token lemma pos cord-029882-kufs0fxe 1 1 key key JJ cord-029882-kufs0fxe 2 1 : : : cord-029882-kufs0fxe 2 2 cord-029882-kufs0fxe cord-029882-kufs0fxe NNS cord-029882-kufs0fxe 2 3 authors author NNS cord-029882-kufs0fxe 2 4 : : : cord-029882-kufs0fxe 2 5 Malviya Malviya NNP cord-029882-kufs0fxe 2 6 , , , cord-029882-kufs0fxe 2 7 Amit Amit NNP cord-029882-kufs0fxe 2 8 title title NN cord-029882-kufs0fxe 2 9 : : : cord-029882-kufs0fxe 3 1 The the DT cord-029882-kufs0fxe 3 2 continued continued JJ cord-029882-kufs0fxe 3 3 dilemma dilemma NN cord-029882-kufs0fxe 3 4 about about IN cord-029882-kufs0fxe 3 5 usage usage NN cord-029882-kufs0fxe 3 6 of of IN cord-029882-kufs0fxe 3 7 Hydroxychloroquine Hydroxychloroquine NNP cord-029882-kufs0fxe 3 8 : : : cord-029882-kufs0fxe 3 9 Respite respite NN cord-029882-kufs0fxe 3 10 is be VBZ cord-029882-kufs0fxe 3 11 in in IN cord-029882-kufs0fxe 3 12 randomized randomized JJ cord-029882-kufs0fxe 3 13 control control NN cord-029882-kufs0fxe 3 14 trials trial NNS cord-029882-kufs0fxe 3 15 date date NN cord-029882-kufs0fxe 3 16 : : : cord-029882-kufs0fxe 3 17 2020 2020 CD cord-029882-kufs0fxe 3 18 - - HYPH cord-029882-kufs0fxe 3 19 07 07 CD cord-029882-kufs0fxe 3 20 - - HYPH cord-029882-kufs0fxe 3 21 29 29 CD cord-029882-kufs0fxe 3 22 journal journal NN cord-029882-kufs0fxe 3 23 : : : cord-029882-kufs0fxe 4 1 Int Int NNP cord-029882-kufs0fxe 4 2 J J NNP cord-029882-kufs0fxe 4 3 Infect infect VB cord-029882-kufs0fxe 4 4 Dis Dis NNP cord-029882-kufs0fxe 4 5 DOI doi NN cord-029882-kufs0fxe 4 6 : : : cord-029882-kufs0fxe 5 1 10.1016 10.1016 CD cord-029882-kufs0fxe 5 2 / / SYM cord-029882-kufs0fxe 5 3 j.ijid.2020.07.054 j.ijid.2020.07.054 NN cord-029882-kufs0fxe 5 4 sha sha NN cord-029882-kufs0fxe 5 5 : : : cord-029882-kufs0fxe 5 6 85b0f1dd0b056310a9905183f1f93b8de6dea0bf 85b0f1dd0b056310a9905183f1f93b8de6dea0bf CD cord-029882-kufs0fxe 5 7 doc_id doc_id CD cord-029882-kufs0fxe 5 8 : : : cord-029882-kufs0fxe 5 9 29882 29882 CD cord-029882-kufs0fxe 5 10 cord_uid cord_uid NNS cord-029882-kufs0fxe 5 11 : : : cord-029882-kufs0fxe 6 1 kufs0fxe kufs0fxe NNP cord-029882-kufs0fxe 6 2 nan nan NNP cord-029882-kufs0fxe 6 3 is be VBZ cord-029882-kufs0fxe 6 4 notable notable JJ cord-029882-kufs0fxe 6 5 that that IN cord-029882-kufs0fxe 6 6 in in IN cord-029882-kufs0fxe 6 7 the the DT cord-029882-kufs0fxe 6 8 present present JJ cord-029882-kufs0fxe 6 9 study study NN cord-029882-kufs0fxe 6 10 , , , cord-029882-kufs0fxe 6 11 concomitant concomitant JJ cord-029882-kufs0fxe 6 12 use use NN cord-029882-kufs0fxe 6 13 of of IN cord-029882-kufs0fxe 6 14 steroid steroid NN cord-029882-kufs0fxe 6 15 in in IN cord-029882-kufs0fxe 6 16 patients patient NNS cord-029882-kufs0fxe 6 17 receiving receive VBG cord-029882-kufs0fxe 6 18 hydroxychloroquine hydroxychloroquine NN cord-029882-kufs0fxe 6 19 , , , cord-029882-kufs0fxe 6 20 was be VBD cord-029882-kufs0fxe 6 21 more more JJR cord-029882-kufs0fxe 6 22 than than IN cord-029882-kufs0fxe 6 23 non non JJ cord-029882-kufs0fxe 6 24 - - JJ cord-029882-kufs0fxe 6 25 treated treated JJ cord-029882-kufs0fxe 6 26 group group NN cord-029882-kufs0fxe 6 27 . . . cord-029882-kufs0fxe 7 1 So so RB cord-029882-kufs0fxe 7 2 , , , cord-029882-kufs0fxe 7 3 in in IN cord-029882-kufs0fxe 7 4 absence absence NN cord-029882-kufs0fxe 7 5 of of IN cord-029882-kufs0fxe 7 6 this this DT cord-029882-kufs0fxe 7 7 critical critical JJ cord-029882-kufs0fxe 7 8 information information NN cord-029882-kufs0fxe 7 9 about about IN cord-029882-kufs0fxe 7 10 the the DT cord-029882-kufs0fxe 7 11 duration duration NN cord-029882-kufs0fxe 7 12 between between IN cord-029882-kufs0fxe 7 13 the the DT cord-029882-kufs0fxe 7 14 onset onset NN cord-029882-kufs0fxe 7 15 of of IN cord-029882-kufs0fxe 7 16 symptoms symptom NNS cord-029882-kufs0fxe 7 17 and and CC cord-029882-kufs0fxe 7 18 administration administration NN cord-029882-kufs0fxe 7 19 of of IN cord-029882-kufs0fxe 7 20 first first JJ cord-029882-kufs0fxe 7 21 dose dose NN cord-029882-kufs0fxe 7 22 of of IN cord-029882-kufs0fxe 7 23 HCQ HCQ NNP cord-029882-kufs0fxe 7 24 , , , cord-029882-kufs0fxe 7 25 it -PRON- PRP cord-029882-kufs0fxe 7 26 seems seem VBZ cord-029882-kufs0fxe 7 27 difficult difficult JJ cord-029882-kufs0fxe 7 28 to to TO cord-029882-kufs0fxe 7 29 interpret interpret VB cord-029882-kufs0fxe 7 30 that that IN cord-029882-kufs0fxe 7 31 the the DT cord-029882-kufs0fxe 7 32 positive positive JJ cord-029882-kufs0fxe 7 33 effects effect NNS cord-029882-kufs0fxe 7 34 were be VBD cord-029882-kufs0fxe 7 35 due due JJ cord-029882-kufs0fxe 7 36 to to IN cord-029882-kufs0fxe 7 37 HCQ HCQ NNP cord-029882-kufs0fxe 7 38 or or CC cord-029882-kufs0fxe 7 39 steroids steroid NNS cord-029882-kufs0fxe 7 40 . . . cord-029882-kufs0fxe 8 1 HCQ HCQ NNP cord-029882-kufs0fxe 8 2 is be VBZ cord-029882-kufs0fxe 8 3 touted tout VBN cord-029882-kufs0fxe 8 4 for for IN cord-029882-kufs0fxe 8 5 treatment treatment NN cord-029882-kufs0fxe 8 6 of of IN cord-029882-kufs0fxe 8 7 Covid Covid NNP cord-029882-kufs0fxe 8 8 19 19 CD cord-029882-kufs0fxe 8 9 primarily primarily RB cord-029882-kufs0fxe 8 10 based base VBN cord-029882-kufs0fxe 8 11 on on IN cord-029882-kufs0fxe 8 12 its -PRON- PRP$ cord-029882-kufs0fxe 8 13 anti anti JJ cord-029882-kufs0fxe 8 14 - - JJ cord-029882-kufs0fxe 8 15 viral viral JJ cord-029882-kufs0fxe 8 16 properties property NNS cord-029882-kufs0fxe 8 17 , , , cord-029882-kufs0fxe 8 18 thus thus RB cord-029882-kufs0fxe 8 19 the the DT cord-029882-kufs0fxe 8 20 timing timing NN cord-029882-kufs0fxe 8 21 of of IN cord-029882-kufs0fxe 8 22 administration administration NN cord-029882-kufs0fxe 8 23 becomes become VBZ cord-029882-kufs0fxe 8 24 very very RB cord-029882-kufs0fxe 8 25 important important JJ cord-029882-kufs0fxe 8 26 for for IN cord-029882-kufs0fxe 8 27 a a DT cord-029882-kufs0fxe 8 28 meaning meaning NN cord-029882-kufs0fxe 8 29 full full JJ cord-029882-kufs0fxe 8 30 assessment assessment NN cord-029882-kufs0fxe 8 31 of of IN cord-029882-kufs0fxe 8 32 study study NN cord-029882-kufs0fxe 8 33 results result NNS cord-029882-kufs0fxe 8 34 . . . cord-029882-kufs0fxe 9 1 Secondly secondly RB cord-029882-kufs0fxe 9 2 , , , cord-029882-kufs0fxe 9 3 HCQ HCQ NNP cord-029882-kufs0fxe 9 4 concentrates concentrate VBZ cord-029882-kufs0fxe 9 5 in in IN cord-029882-kufs0fxe 9 6 lungs lung NNS cord-029882-kufs0fxe 9 7 after after IN cord-029882-kufs0fxe 9 8 initial initial JJ cord-029882-kufs0fxe 9 9 doses dose NNS cord-029882-kufs0fxe 9 10 3 3 CD cord-029882-kufs0fxe 9 11 and and CC cord-029882-kufs0fxe 9 12 that that DT cord-029882-kufs0fxe 9 13 is be VBZ cord-029882-kufs0fxe 9 14 the the DT cord-029882-kufs0fxe 9 15 time time NN cord-029882-kufs0fxe 9 16 when when WRB cord-029882-kufs0fxe 9 17 its -PRON- PRP$ cord-029882-kufs0fxe 9 18 effect effect NN cord-029882-kufs0fxe 9 19 is be VBZ cord-029882-kufs0fxe 9 20 supposed suppose VBN cord-029882-kufs0fxe 9 21 to to TO cord-029882-kufs0fxe 9 22 be be VB cord-029882-kufs0fxe 9 23 maximum maximum JJ cord-029882-kufs0fxe 9 24 . . . cord-029882-kufs0fxe 10 1 Administration Administration NNP cord-029882-kufs0fxe 10 2 of of IN cord-029882-kufs0fxe 10 3 HCQ HCQ NNP cord-029882-kufs0fxe 10 4 late late RB cord-029882-kufs0fxe 10 5 in in IN cord-029882-kufs0fxe 10 6 the the DT cord-029882-kufs0fxe 10 7 course course NN cord-029882-kufs0fxe 10 8 of of IN cord-029882-kufs0fxe 10 9 disease disease NN cord-029882-kufs0fxe 10 10 may may MD cord-029882-kufs0fxe 10 11 not not RB cord-029882-kufs0fxe 10 12 be be VB cord-029882-kufs0fxe 10 13 that that DT cord-029882-kufs0fxe 10 14 effective effective JJ cord-029882-kufs0fxe 10 15 . . . cord-029882-kufs0fxe 11 1 Thirdly thirdly RB cord-029882-kufs0fxe 11 2 , , , cord-029882-kufs0fxe 11 3 they -PRON- PRP cord-029882-kufs0fxe 11 4 utilised utilise VBD cord-029882-kufs0fxe 11 5 maximal maximal RB cord-029882-kufs0fxe 11 6 modified modify VBD cord-029882-kufs0fxe 11 7 Sequential Sequential NNP cord-029882-kufs0fxe 11 8 Organ Organ NNP cord-029882-kufs0fxe 11 9 Failure Failure NNP cord-029882-kufs0fxe 11 10 Assessment Assessment NNP cord-029882-kufs0fxe 11 11 ( ( -LRB- cord-029882-kufs0fxe 11 12 mSOFA mSOFA NNP cord-029882-kufs0fxe 11 13 ) ) -RRB- cord-029882-kufs0fxe 11 14 scores score NNS cord-029882-kufs0fxe 11 15 for for IN cord-029882-kufs0fxe 11 16 classifying classify VBG cord-029882-kufs0fxe 11 17 patient patient JJ cord-029882-kufs0fxe 11 18 severity severity NN cord-029882-kufs0fxe 11 19 of of IN cord-029882-kufs0fxe 11 20 disease disease NN cord-029882-kufs0fxe 11 21 . . . cord-029882-kufs0fxe 12 1 Recently recently RB cord-029882-kufs0fxe 12 2 it -PRON- PRP cord-029882-kufs0fxe 12 3 been be VBN cord-029882-kufs0fxe 12 4 shown show VBN cord-029882-kufs0fxe 12 5 that that IN cord-029882-kufs0fxe 12 6 this this DT cord-029882-kufs0fxe 12 7 score score NN cord-029882-kufs0fxe 12 8 is be VBZ cord-029882-kufs0fxe 12 9 not not RB cord-029882-kufs0fxe 12 10 accurate accurate JJ cord-029882-kufs0fxe 12 11 for for IN cord-029882-kufs0fxe 12 12 predicting predict VBG cord-029882-kufs0fxe 12 13 severity severity NN cord-029882-kufs0fxe 12 14 of of IN cord-029882-kufs0fxe 12 15 disease disease NN cord-029882-kufs0fxe 12 16 in in IN cord-029882-kufs0fxe 12 17 Covid Covid NNP cord-029882-kufs0fxe 12 18 19 19 CD cord-029882-kufs0fxe 12 19 patients patient NNS cord-029882-kufs0fxe 12 20 . . . cord-029882-kufs0fxe 13 1 4 4 LS cord-029882-kufs0fxe 13 2 Fourthly fourthly RB cord-029882-kufs0fxe 13 3 , , , cord-029882-kufs0fxe 13 4 a a DT cord-029882-kufs0fxe 13 5 QTc QTc NNP cord-029882-kufs0fxe 13 6 interval interval NN cord-029882-kufs0fxe 13 7 - - HYPH cord-029882-kufs0fxe 13 8 based base VBN cord-029882-kufs0fxe 13 9 algorithm algorithm NN cord-029882-kufs0fxe 13 10 specifically specifically RB cord-029882-kufs0fxe 13 11 designed design VBN cord-029882-kufs0fxe 13 12 to to TO cord-029882-kufs0fxe 13 13 ensure ensure VB cord-029882-kufs0fxe 13 14 the the DT cord-029882-kufs0fxe 13 15 safe safe JJ cord-029882-kufs0fxe 13 16 use use NN cord-029882-kufs0fxe 13 17 of of IN cord-029882-kufs0fxe 13 18 hydroxychloroquine hydroxychloroquine NN cord-029882-kufs0fxe 13 19 was be VBD cord-029882-kufs0fxe 13 20 utilised utilise VBN cord-029882-kufs0fxe 13 21 . . . cord-029882-kufs0fxe 14 1 This this DT cord-029882-kufs0fxe 14 2 is be VBZ cord-029882-kufs0fxe 14 3 a a DT cord-029882-kufs0fxe 14 4 very very RB cord-029882-kufs0fxe 14 5 safe safe JJ cord-029882-kufs0fxe 14 6 practice practice NN cord-029882-kufs0fxe 14 7 but but CC cord-029882-kufs0fxe 14 8 it -PRON- PRP cord-029882-kufs0fxe 14 9 might may MD cord-029882-kufs0fxe 14 10 have have VB cord-029882-kufs0fxe 14 11 resulted result VBN cord-029882-kufs0fxe 14 12 in in IN cord-029882-kufs0fxe 14 13 exclusion exclusion NN cord-029882-kufs0fxe 14 14 of of IN cord-029882-kufs0fxe 14 15 high high JJ cord-029882-kufs0fxe 14 16 cardiac cardiac JJ cord-029882-kufs0fxe 14 17 risk risk NN cord-029882-kufs0fxe 14 18 patients patient NNS cord-029882-kufs0fxe 14 19 . . . cord-029882-kufs0fxe 15 1 Covid Covid NNP cord-029882-kufs0fxe 15 2 19 19 CD cord-029882-kufs0fxe 15 3 is be VBZ cord-029882-kufs0fxe 15 4 a a DT cord-029882-kufs0fxe 15 5 multisystem multisystem JJ cord-029882-kufs0fxe 15 6 disease disease NN cord-029882-kufs0fxe 15 7 and and CC cord-029882-kufs0fxe 15 8 the the DT cord-029882-kufs0fxe 15 9 disease disease NN cord-029882-kufs0fxe 15 10 itself -PRON- PRP cord-029882-kufs0fxe 15 11 promotes promote VBZ cord-029882-kufs0fxe 15 12 proarrhythmic proarrhythmic JJ cord-029882-kufs0fxe 15 13 milieu milieu NN cord-029882-kufs0fxe 15 14 with with IN cord-029882-kufs0fxe 15 15 prolonged prolonged JJ cord-029882-kufs0fxe 15 16 QT qt NN cord-029882-kufs0fxe 15 17 intervals interval NNS cord-029882-kufs0fxe 15 18 at at IN cord-029882-kufs0fxe 15 19 baseline baseline NN cord-029882-kufs0fxe 15 20 .5,6 .5,6 . cord-029882-kufs0fxe 16 1 Risk risk NN cord-029882-kufs0fxe 16 2 assessment assessment NN cord-029882-kufs0fxe 16 3 of of IN cord-029882-kufs0fxe 16 4 HCQ HCQ NNP cord-029882-kufs0fxe 16 5 therapy therapy NN cord-029882-kufs0fxe 16 6 is be VBZ cord-029882-kufs0fxe 16 7 not not RB cord-029882-kufs0fxe 16 8 complete complete JJ cord-029882-kufs0fxe 16 9 if if IN cord-029882-kufs0fxe 16 10 such such JJ cord-029882-kufs0fxe 16 11 patients patient NNS cord-029882-kufs0fxe 16 12 are be VBP cord-029882-kufs0fxe 16 13 excluded exclude VBN cord-029882-kufs0fxe 16 14 . . . cord-029882-kufs0fxe 17 1 Finally finally RB cord-029882-kufs0fxe 17 2 , , , cord-029882-kufs0fxe 17 3 mechanism mechanism NN cord-029882-kufs0fxe 17 4 of of IN cord-029882-kufs0fxe 17 5 action action NN cord-029882-kufs0fxe 17 6 of of IN cord-029882-kufs0fxe 17 7 HCQ HCQ NNP cord-029882-kufs0fxe 17 8 against against IN cord-029882-kufs0fxe 17 9 is be VBZ cord-029882-kufs0fxe 17 10 a a DT cord-029882-kufs0fxe 17 11 part part NN cord-029882-kufs0fxe 17 12 of of IN cord-029882-kufs0fxe 17 13 its -PRON- PRP$ cord-029882-kufs0fxe 17 14 broad broad JJ cord-029882-kufs0fxe 17 15 anti anti JJ cord-029882-kufs0fxe 17 16 - - JJ cord-029882-kufs0fxe 17 17 viral viral JJ cord-029882-kufs0fxe 17 18 and and CC cord-029882-kufs0fxe 17 19 immunomodulatory immunomodulatory JJ cord-029882-kufs0fxe 17 20 properties property NNS cord-029882-kufs0fxe 17 21 and and CC cord-029882-kufs0fxe 17 22 no no DT cord-029882-kufs0fxe 17 23 specific specific JJ cord-029882-kufs0fxe 17 24 pharmacologic pharmacologic JJ cord-029882-kufs0fxe 17 25 actions action NNS cord-029882-kufs0fxe 17 26 are be VBP cord-029882-kufs0fxe 17 27 described describe VBN cord-029882-kufs0fxe 17 28 for for IN cord-029882-kufs0fxe 17 29 SARS SARS NNP cord-029882-kufs0fxe 17 30 - - HYPH cord-029882-kufs0fxe 17 31 CoV-2 CoV-2 NNP cord-029882-kufs0fxe 17 32 infection infection NN cord-029882-kufs0fxe 17 33 . . . cord-029882-kufs0fxe 18 1 7 7 CD cord-029882-kufs0fxe 18 2 , , , cord-029882-kufs0fxe 18 3 8 8 CD cord-029882-kufs0fxe 18 4 Majority majority NN cord-029882-kufs0fxe 18 5 of of IN cord-029882-kufs0fxe 18 6 publications publication NNS cord-029882-kufs0fxe 18 7 in in IN cord-029882-kufs0fxe 18 8 the the DT cord-029882-kufs0fxe 18 9 recent recent JJ cord-029882-kufs0fxe 18 10 times time NNS cord-029882-kufs0fxe 18 11 on on IN cord-029882-kufs0fxe 18 12 HCQ HCQ NNP cord-029882-kufs0fxe 18 13 , , , cord-029882-kufs0fxe 18 14 for for IN cord-029882-kufs0fxe 18 15 usage usage NN cord-029882-kufs0fxe 18 16 in in IN cord-029882-kufs0fxe 18 17 Covid Covid NNP cord-029882-kufs0fxe 18 18 19 19 CD cord-029882-kufs0fxe 18 19 , , , cord-029882-kufs0fxe 18 20 are be VBP cord-029882-kufs0fxe 18 21 limited limit VBN cord-029882-kufs0fxe 18 22 by by IN cord-029882-kufs0fxe 18 23 low low JJ cord-029882-kufs0fxe 18 24 methodical methodical JJ cord-029882-kufs0fxe 18 25 quality quality NN cord-029882-kufs0fxe 18 26 and and CC cord-029882-kufs0fxe 18 27 by by IN cord-029882-kufs0fxe 18 28 and and CC cord-029882-kufs0fxe 18 29 large large JJ cord-029882-kufs0fxe 18 30 have have VBP cord-029882-kufs0fxe 18 31 shown show VBN cord-029882-kufs0fxe 18 32 negative negative JJ cord-029882-kufs0fxe 18 33 or or CC cord-029882-kufs0fxe 18 34 neutral neutral JJ cord-029882-kufs0fxe 18 35 results result NNS cord-029882-kufs0fxe 18 36 . . . cord-029882-kufs0fxe 19 1 9,10 9,10 LS cord-029882-kufs0fxe 19 2 Weather Weather NNP cord-029882-kufs0fxe 19 3 HCQ HCQ NNP cord-029882-kufs0fxe 19 4 as as IN cord-029882-kufs0fxe 19 5 initial initial JJ cord-029882-kufs0fxe 19 6 anti anti JJ cord-029882-kufs0fxe 19 7 - - JJ cord-029882-kufs0fxe 19 8 viral viral JJ cord-029882-kufs0fxe 19 9 agent agent NN cord-029882-kufs0fxe 19 10 prevents prevent VBZ cord-029882-kufs0fxe 19 11 progression progression NN cord-029882-kufs0fxe 19 12 to to IN cord-029882-kufs0fxe 19 13 severe severe JJ cord-029882-kufs0fxe 19 14 disease disease NN cord-029882-kufs0fxe 19 15 is be VBZ cord-029882-kufs0fxe 19 16 not not RB cord-029882-kufs0fxe 19 17 known know VBN cord-029882-kufs0fxe 19 18 clearly clearly RB cord-029882-kufs0fxe 19 19 . . . cord-029882-kufs0fxe 20 1 In in IN cord-029882-kufs0fxe 20 2 severe severe JJ cord-029882-kufs0fxe 20 3 disease disease NN cord-029882-kufs0fxe 20 4 with with IN cord-029882-kufs0fxe 20 5 multi multi JJ cord-029882-kufs0fxe 20 6 system system NN cord-029882-kufs0fxe 20 7 involvement involvement NN cord-029882-kufs0fxe 20 8 and and CC cord-029882-kufs0fxe 20 9 pro pro JJ cord-029882-kufs0fxe 20 10 arrhythmic arrhythmic JJ cord-029882-kufs0fxe 20 11 milieu milieu NN cord-029882-kufs0fxe 20 12 COVID-19 covid-19 NN cord-029882-kufs0fxe 20 13 : : : cord-029882-kufs0fxe 20 14 immunopathology immunopathology NN cord-029882-kufs0fxe 20 15 and and CC cord-029882-kufs0fxe 20 16 its -PRON- PRP$ cord-029882-kufs0fxe 20 17 implications implication NNS cord-029882-kufs0fxe 20 18 for for IN cord-029882-kufs0fxe 20 19 therapy therapy NN cord-029882-kufs0fxe 20 20 Pharmacologic Pharmacologic NNP cord-029882-kufs0fxe 20 21 treatments treatment NNS cord-029882-kufs0fxe 20 22 for for IN cord-029882-kufs0fxe 20 23 coronavirus coronavirus NN cord-029882-kufs0fxe 20 24 disease disease NN cord-029882-kufs0fxe 20 25 2019 2019 CD cord-029882-kufs0fxe 20 26 ( ( -LRB- cord-029882-kufs0fxe 20 27 COVID-19 COVID-19 NNP cord-029882-kufs0fxe 20 28 ) ) -RRB- cord-029882-kufs0fxe 20 29 : : : cord-029882-kufs0fxe 20 30 a a DT cord-029882-kufs0fxe 20 31 review review NN cord-029882-kufs0fxe 20 32 Mechanisms Mechanisms NNPS cord-029882-kufs0fxe 20 33 of of IN cord-029882-kufs0fxe 20 34 action action NN cord-029882-kufs0fxe 20 35 of of IN cord-029882-kufs0fxe 20 36 hydroxychloroquine hydroxychloroquine NNP cord-029882-kufs0fxe 20 37 and and CC cord-029882-kufs0fxe 20 38 chloroquine chloroquine NN cord-029882-kufs0fxe 20 39 : : : cord-029882-kufs0fxe 20 40 implications implication NNS cord-029882-kufs0fxe 20 41 for for IN cord-029882-kufs0fxe 20 42 rheumatology rheumatology NN cord-029882-kufs0fxe 20 43 Critically critically RB cord-029882-kufs0fxe 20 44 ill ill JJ cord-029882-kufs0fxe 20 45 SARS SARS NNP cord-029882-kufs0fxe 20 46 - - HYPH cord-029882-kufs0fxe 20 47 CoV2-infected cov2-infecte VBN cord-029882-kufs0fxe 20 48 patients patient NNS cord-029882-kufs0fxe 20 49 are be VBP cord-029882-kufs0fxe 20 50 not not RB cord-029882-kufs0fxe 20 51 stratified stratify VBN cord-029882-kufs0fxe 20 52 as as IN cord-029882-kufs0fxe 20 53 sepsis sepsis NN cord-029882-kufs0fxe 20 54 by by IN cord-029882-kufs0fxe 20 55 the the DT cord-029882-kufs0fxe 20 56 qSOFA qsofa JJ cord-029882-kufs0fxe 20 57 Chloroquine Chloroquine NNP cord-029882-kufs0fxe 20 58 and and CC cord-029882-kufs0fxe 20 59 hydroxychloroquine hydroxychloroquine NN cord-029882-kufs0fxe 20 60 in in IN cord-029882-kufs0fxe 20 61 covid-19 covid-19 NNP cord-029882-kufs0fxe 20 62 Ventricular Ventricular NNP cord-029882-kufs0fxe 20 63 arrhythmia arrhythmia NN cord-029882-kufs0fxe 20 64 risk risk NN cord-029882-kufs0fxe 20 65 due due IN cord-029882-kufs0fxe 20 66 to to IN cord-029882-kufs0fxe 20 67 chloroquine chloroquine NN cord-029882-kufs0fxe 20 68 / / SYM cord-029882-kufs0fxe 20 69 hydroxychloroquine hydroxychloroquine NN cord-029882-kufs0fxe 20 70 treatment treatment NN cord-029882-kufs0fxe 20 71 for for IN cord-029882-kufs0fxe 20 72 COVID-19 covid-19 NN cord-029882-kufs0fxe 20 73 : : : cord-029882-kufs0fxe 20 74 Should Should MD cord-029882-kufs0fxe 20 75 it -PRON- PRP cord-029882-kufs0fxe 20 76 be be VB cord-029882-kufs0fxe 20 77 given give VBN cord-029882-kufs0fxe 21 1 In in IN cord-029882-kufs0fxe 21 2 vitro vitro FW cord-029882-kufs0fxe 21 3 antiviral antiviral JJ cord-029882-kufs0fxe 21 4 activity activity NN cord-029882-kufs0fxe 21 5 and and CC cord-029882-kufs0fxe 21 6 projection projection NN cord-029882-kufs0fxe 21 7 of of IN cord-029882-kufs0fxe 21 8 optimized optimize VBN cord-029882-kufs0fxe 21 9 dosing dosing NN cord-029882-kufs0fxe 21 10 design design NN cord-029882-kufs0fxe 21 11 of of IN cord-029882-kufs0fxe 21 12 hydroxychloroquine hydroxychloroquine NN cord-029882-kufs0fxe 21 13 for for IN cord-029882-kufs0fxe 21 14 the the DT cord-029882-kufs0fxe 21 15 treatment treatment NN cord-029882-kufs0fxe 21 16 of of IN cord-029882-kufs0fxe 21 17 severe severe JJ cord-029882-kufs0fxe 21 18 acute acute JJ cord-029882-kufs0fxe 21 19 respiratory respiratory JJ cord-029882-kufs0fxe 21 20 syndrome syndrome NN cord-029882-kufs0fxe 21 21 coronavirus coronavirus NN cord-029882-kufs0fxe 21 22 2 2 CD cord-029882-kufs0fxe 22 1 ( ( -LRB- cord-029882-kufs0fxe 22 2 SARS SARS NNP cord-029882-kufs0fxe 22 3 - - HYPH cord-029882-kufs0fxe 22 4 CoV-2 CoV-2 NNP cord-029882-kufs0fxe 22 5 ) ) -RRB- cord-029882-kufs0fxe 22 6 Effects effect NNS cord-029882-kufs0fxe 22 7 of of IN cord-029882-kufs0fxe 22 8 chloroquine chloroquine NN cord-029882-kufs0fxe 22 9 on on IN cord-029882-kufs0fxe 22 10 viral viral JJ cord-029882-kufs0fxe 22 11 infections infection NNS cord-029882-kufs0fxe 22 12 : : : cord-029882-kufs0fxe 22 13 an an DT cord-029882-kufs0fxe 22 14 old old JJ cord-029882-kufs0fxe 22 15 drug drug NN cord-029882-kufs0fxe 22 16 against against IN cord-029882-kufs0fxe 22 17 today today NN cord-029882-kufs0fxe 22 18 's 's POS cord-029882-kufs0fxe 22 19 diseases disease NNS cord-029882-kufs0fxe 22 20 ? ? . cord-029882-kufs0fxe 23 1 The the DT cord-029882-kufs0fxe 23 2 Lancet Lancet NNP cord-029882-kufs0fxe 23 3 . . . cord-029882-kufs0fxe 24 1 Infectious infectious JJ cord-029882-kufs0fxe 24 2 Diseases disease NNS cord-029882-kufs0fxe 25 1 The the DT cord-029882-kufs0fxe 25 2 Urgency Urgency NNP cord-029882-kufs0fxe 25 3 of of IN cord-029882-kufs0fxe 25 4 Care Care NNP cord-029882-kufs0fxe 25 5 during during IN cord-029882-kufs0fxe 25 6 the the DT cord-029882-kufs0fxe 25 7 Covid-19 Covid-19 NNP cord-029882-kufs0fxe 25 8 Pandemic Pandemic NNP cord-029882-kufs0fxe 25 9 -Learning -Learning . cord-029882-kufs0fxe 25 10 as as IN cord-029882-kufs0fxe 25 11 We -PRON- PRP cord-029882-kufs0fxe 25 12 Go go VBP cord-029882-kufs0fxe 25 13 COVID-19 COVID-19 NNP cord-029882-kufs0fxe 25 14 coronavirus coronavirus NN cord-029882-kufs0fxe 25 15 research research NN cord-029882-kufs0fxe 25 16 has have VBZ cord-029882-kufs0fxe 25 17 overall overall RB cord-029882-kufs0fxe 25 18 low low JJ cord-029882-kufs0fxe 25 19 methodological methodological JJ cord-029882-kufs0fxe 25 20 quality quality NN cord-029882-kufs0fxe 25 21 thus thus RB cord-029882-kufs0fxe 25 22 far far RB cord-029882-kufs0fxe 25 23 : : : cord-029882-kufs0fxe 25 24 case case NN cord-029882-kufs0fxe 25 25 in in IN cord-029882-kufs0fxe 25 26 point point NN cord-029882-kufs0fxe 25 27 for for IN cord-029882-kufs0fxe 25 28 chloroquine chloroquine NN cord-029882-kufs0fxe 25 29 / / SYM cord-029882-kufs0fxe 25 30 hydroxychloroquine hydroxychloroquine NNP