id sid tid token lemma pos cord-259957-temt8b6f 1 1 key key NN cord-259957-temt8b6f 1 2 : : : cord-259957-temt8b6f 2 1 cord-259957-temt8b6f cord-259957-temt8b6f JJ cord-259957-temt8b6f 2 2 authors author NNS cord-259957-temt8b6f 2 3 : : : cord-259957-temt8b6f 2 4 Brown Brown NNP cord-259957-temt8b6f 2 5 , , , cord-259957-temt8b6f 2 6 Ronald Ronald NNP cord-259957-temt8b6f 2 7 title title NN cord-259957-temt8b6f 2 8 : : : cord-259957-temt8b6f 2 9 Hydroxychloroquine Hydroxychloroquine NNP cord-259957-temt8b6f 2 10 and and CC cord-259957-temt8b6f 2 11 “ " `` cord-259957-temt8b6f 2 12 off off IN cord-259957-temt8b6f 2 13 - - HYPH cord-259957-temt8b6f 2 14 label label NN cord-259957-temt8b6f 2 15 ” " '' cord-259957-temt8b6f 2 16 utilization utilization NN cord-259957-temt8b6f 2 17 in in IN cord-259957-temt8b6f 2 18 the the DT cord-259957-temt8b6f 2 19 treatment treatment NN cord-259957-temt8b6f 2 20 of of IN cord-259957-temt8b6f 2 21 oral oral JJ cord-259957-temt8b6f 2 22 conditions condition NNS cord-259957-temt8b6f 2 23 date date NN cord-259957-temt8b6f 2 24 : : : cord-259957-temt8b6f 2 25 2020 2020 CD cord-259957-temt8b6f 2 26 - - HYPH cord-259957-temt8b6f 2 27 04 04 CD cord-259957-temt8b6f 2 28 - - HYPH cord-259957-temt8b6f 2 29 11 11 CD cord-259957-temt8b6f 2 30 journal journal NN cord-259957-temt8b6f 2 31 : : : cord-259957-temt8b6f 2 32 Oral oral JJ cord-259957-temt8b6f 2 33 Surg Surg NNP cord-259957-temt8b6f 2 34 Oral Oral NNP cord-259957-temt8b6f 2 35 Med Med NNP cord-259957-temt8b6f 2 36 Oral oral JJ cord-259957-temt8b6f 2 37 Pathol Pathol NNP cord-259957-temt8b6f 2 38 Oral Oral NNP cord-259957-temt8b6f 2 39 Radiol Radiol NNP cord-259957-temt8b6f 2 40 DOI DOI NNP cord-259957-temt8b6f 2 41 : : : cord-259957-temt8b6f 2 42 10.1016/ 10.1016/ CD cord-259957-temt8b6f 3 1 j.oooo.2020.03.047 j.oooo.2020.03.047 NNP cord-259957-temt8b6f 4 1 sha sha NNP cord-259957-temt8b6f 4 2 : : : cord-259957-temt8b6f 5 1 775a42a05c5e3ce09d907bf7c22bb59d13b756cc 775a42a05c5e3ce09d907bf7c22bb59d13b756cc CD cord-259957-temt8b6f 5 2 doc_id doc_id CD cord-259957-temt8b6f 5 3 : : : cord-259957-temt8b6f 6 1 259957 259957 CD cord-259957-temt8b6f 6 2 cord_uid cord_uid NNS cord-259957-temt8b6f 6 3 : : : cord-259957-temt8b6f 6 4 temt8b6f temt8b6f NNP cord-259957-temt8b6f 6 5 nan nan NNP cord-259957-temt8b6f 6 6 Hydroxychloroquine Hydroxychloroquine NNP cord-259957-temt8b6f 6 7 and and CC cord-259957-temt8b6f 6 8 " " `` cord-259957-temt8b6f 6 9 off off IN cord-259957-temt8b6f 6 10 - - HYPH cord-259957-temt8b6f 6 11 label label NN cord-259957-temt8b6f 6 12 " " '' cord-259957-temt8b6f 6 13 utilization utilization NN cord-259957-temt8b6f 6 14 in in IN cord-259957-temt8b6f 6 15 the the DT cord-259957-temt8b6f 6 16 treatment treatment NN cord-259957-temt8b6f 6 17 of of IN cord-259957-temt8b6f 6 18 oral oral JJ cord-259957-temt8b6f 6 19 conditions condition NNS cord-259957-temt8b6f 6 20 To to IN cord-259957-temt8b6f 6 21 the the DT cord-259957-temt8b6f 6 22 Editor editor NN cord-259957-temt8b6f 6 23 : : : cord-259957-temt8b6f 7 1 In in IN cord-259957-temt8b6f 7 2 response response NN cord-259957-temt8b6f 7 3 to to IN cord-259957-temt8b6f 7 4 President President NNP cord-259957-temt8b6f 7 5 Trump Trump NNP cord-259957-temt8b6f 7 6 's 's POS cord-259957-temt8b6f 7 7 remarks remark NNS cord-259957-temt8b6f 7 8 made make VBN cord-259957-temt8b6f 7 9 on on IN cord-259957-temt8b6f 7 10 March March NNP cord-259957-temt8b6f 7 11 19 19 CD cord-259957-temt8b6f 7 12 , , , cord-259957-temt8b6f 7 13 2020 2020 CD cord-259957-temt8b6f 7 14 , , , cord-259957-temt8b6f 7 15 concerning concern VBG cord-259957-temt8b6f 7 16 the the DT cord-259957-temt8b6f 7 17 potential potential NN cord-259957-temt8b6f 7 18 of of IN cord-259957-temt8b6f 7 19 chloroquine chloroquine NN cord-259957-temt8b6f 7 20 and and CC cord-259957-temt8b6f 7 21 hydroxychloroquine hydroxychloroquine NNP cord-259957-temt8b6f 7 22 ( ( -LRB- cord-259957-temt8b6f 7 23 HCQ HCQ NNP cord-259957-temt8b6f 7 24 ) ) -RRB- cord-259957-temt8b6f 7 25 as as IN cord-259957-temt8b6f 7 26 treatment treatment NN cord-259957-temt8b6f 7 27 for for IN cord-259957-temt8b6f 7 28 the the DT cord-259957-temt8b6f 7 29 novel novel JJ cord-259957-temt8b6f 7 30 coronavirus-19 coronavirus-19 CD cord-259957-temt8b6f 7 31 infections infection NNS cord-259957-temt8b6f 7 32 : : : cord-259957-temt8b6f 7 33 " " `` cord-259957-temt8b6f 7 34 The the DT cord-259957-temt8b6f 7 35 U.S. U.S. NNP cord-259957-temt8b6f 7 36 Food Food NNP cord-259957-temt8b6f 7 37 and and CC cord-259957-temt8b6f 7 38 Drug Drug NNP cord-259957-temt8b6f 7 39 Administration Administration NNP cord-259957-temt8b6f 7 40 ( ( -LRB- cord-259957-temt8b6f 7 41 FDA FDA NNP cord-259957-temt8b6f 7 42 ) ) -RRB- cord-259957-temt8b6f 7 43 swiftly swiftly RB cord-259957-temt8b6f 7 44 issued issue VBD cord-259957-temt8b6f 7 45 a a DT cord-259957-temt8b6f 7 46 statement statement NN cord-259957-temt8b6f 7 47 to to TO cord-259957-temt8b6f 7 48 clarify clarify VB cord-259957-temt8b6f 7 49 that that DT cord-259957-temt8b6f 7 50 , , , cord-259957-temt8b6f 7 51 no no UH cord-259957-temt8b6f 7 52 , , , cord-259957-temt8b6f 7 53 these these DT cord-259957-temt8b6f 7 54 drugs drug NNS cord-259957-temt8b6f 7 55 are be VBP cord-259957-temt8b6f 7 56 not not RB cord-259957-temt8b6f 7 57 approved approve VBN cord-259957-temt8b6f 7 58 as as IN cord-259957-temt8b6f 7 59 treatments treatment NNS cord-259957-temt8b6f 7 60 for for IN cord-259957-temt8b6f 7 61 COVID-19 COVID-19 NNP cord-259957-temt8b6f 7 62 , , , cord-259957-temt8b6f 7 63 the the DT cord-259957-temt8b6f 7 64 disease disease NN cord-259957-temt8b6f 7 65 caused cause VBN cord-259957-temt8b6f 7 66 by by IN cord-259957-temt8b6f 7 67 the the DT cord-259957-temt8b6f 7 68 coronavirus coronavirus NN cord-259957-temt8b6f 7 69 SARS SARS NNP cord-259957-temt8b6f 7 70 - - HYPH cord-259957-temt8b6f 7 71 CoV-2 CoV-2 NNP cord-259957-temt8b6f 7 72 . . . cord-259957-temt8b6f 8 1 Both both DT cord-259957-temt8b6f 8 2 drugs drug NNS cord-259957-temt8b6f 8 3 are be VBP cord-259957-temt8b6f 8 4 approved approve VBN cord-259957-temt8b6f 8 5 to to TO cord-259957-temt8b6f 8 6 treat treat VB cord-259957-temt8b6f 8 7 malaria malaria NN cord-259957-temt8b6f 8 8 , , , cord-259957-temt8b6f 8 9 lupus lupus NN cord-259957-temt8b6f 8 10 , , , cord-259957-temt8b6f 8 11 and and CC cord-259957-temt8b6f 8 12 rheumatoid rheumatoid NN cord-259957-temt8b6f 8 13 arthritis arthritis NN cord-259957-temt8b6f 8 14 but but CC cord-259957-temt8b6f 8 15 must must MD cord-259957-temt8b6f 8 16 still still RB cord-259957-temt8b6f 8 17 be be VB cord-259957-temt8b6f 8 18 assessed assess VBN cord-259957-temt8b6f 8 19 in in IN cord-259957-temt8b6f 8 20 clinical clinical JJ cord-259957-temt8b6f 8 21 trials trial NNS cord-259957-temt8b6f 8 22 before before IN cord-259957-temt8b6f 8 23 being be VBG cord-259957-temt8b6f 8 24 declared declare VBN cord-259957-temt8b6f 8 25 a a DT cord-259957-temt8b6f 8 26 safe safe JJ cord-259957-temt8b6f 8 27 and and CC cord-259957-temt8b6f 8 28 effective effective JJ cord-259957-temt8b6f 8 29 COVID-19 COVID-19 NNP cord-259957-temt8b6f 8 30 treatment treatment NN cord-259957-temt8b6f 8 31 . . . cord-259957-temt8b6f 9 1 Doctors doctor NNS cord-259957-temt8b6f 9 2 in in IN cord-259957-temt8b6f 9 3 the the DT cord-259957-temt8b6f 9 4 United United NNP cord-259957-temt8b6f 9 5 States States NNP cord-259957-temt8b6f 9 6 have have VBP cord-259957-temt8b6f 9 7 wide wide JJ cord-259957-temt8b6f 9 8 latitude latitude NN cord-259957-temt8b6f 9 9 to to TO cord-259957-temt8b6f 9 10 prescribe prescribe VB cord-259957-temt8b6f 9 11 drugs drug NNS cord-259957-temt8b6f 9 12 " " `` cord-259957-temt8b6f 9 13 off off IN cord-259957-temt8b6f 9 14 - - HYPH cord-259957-temt8b6f 9 15 label label NN cord-259957-temt8b6f 9 16 , , , cord-259957-temt8b6f 9 17 " " '' cord-259957-temt8b6f 9 18 meaning mean VBG cord-259957-temt8b6f 9 19 for for IN cord-259957-temt8b6f 9 20 conditions condition NNS cord-259957-temt8b6f 9 21 beyond beyond IN cord-259957-temt8b6f 9 22 their -PRON- PRP$ cord-259957-temt8b6f 9 23 initial initial JJ cord-259957-temt8b6f 9 24 FDA FDA NNP cord-259957-temt8b6f 9 25 approval approval NN cord-259957-temt8b6f 9 26 . . . cord-259957-temt8b6f 10 1 " " `` cord-259957-temt8b6f 10 2 1 1 CD cord-259957-temt8b6f 10 3 HCQ HCQ NNP cord-259957-temt8b6f 10 4 may may MD cord-259957-temt8b6f 10 5 or or CC cord-259957-temt8b6f 10 6 may may MD cord-259957-temt8b6f 10 7 not not RB cord-259957-temt8b6f 10 8 pan pan VB cord-259957-temt8b6f 10 9 out out RP cord-259957-temt8b6f 10 10 to to TO cord-259957-temt8b6f 10 11 be be VB cord-259957-temt8b6f 10 12 a a DT cord-259957-temt8b6f 10 13 successful successful JJ cord-259957-temt8b6f 10 14 therapeutic therapeutic JJ cord-259957-temt8b6f 10 15 agent agent NN cord-259957-temt8b6f 10 16 in in IN cord-259957-temt8b6f 10 17 the the DT cord-259957-temt8b6f 10 18 treatment treatment NN cord-259957-temt8b6f 10 19 for for IN cord-259957-temt8b6f 10 20 COVID-19 covid-19 JJ cord-259957-temt8b6f 10 21 infections infection NNS cord-259957-temt8b6f 10 22 . . . cord-259957-temt8b6f 11 1 However however RB cord-259957-temt8b6f 11 2 , , , cord-259957-temt8b6f 11 3 it -PRON- PRP cord-259957-temt8b6f 11 4 appears appear VBZ cord-259957-temt8b6f 11 5 likely likely JJ cord-259957-temt8b6f 11 6 that that IN cord-259957-temt8b6f 11 7 many many JJ cord-259957-temt8b6f 11 8 health health NN cord-259957-temt8b6f 11 9 care care NN cord-259957-temt8b6f 11 10 providers provider NNS cord-259957-temt8b6f 11 11 may may MD cord-259957-temt8b6f 11 12 begin begin VB cord-259957-temt8b6f 11 13 using use VBG cord-259957-temt8b6f 11 14 this this DT cord-259957-temt8b6f 11 15 drug drug NN cord-259957-temt8b6f 11 16 without without IN cord-259957-temt8b6f 11 17 knowledge knowledge NN cord-259957-temt8b6f 11 18 of of IN cord-259957-temt8b6f 11 19 accepted accept VBN cord-259957-temt8b6f 11 20 dosage dosage NN cord-259957-temt8b6f 11 21 regimens regimen NNS cord-259957-temt8b6f 11 22 and and CC cord-259957-temt8b6f 11 23 toxicity toxicity NN cord-259957-temt8b6f 11 24 . . . cord-259957-temt8b6f 12 1 HCQ HCQ NNP cord-259957-temt8b6f 12 2 is be VBZ cord-259957-temt8b6f 12 3 a a DT cord-259957-temt8b6f 12 4 drug drug NN cord-259957-temt8b6f 12 5 specifically specifically RB cord-259957-temt8b6f 12 6 approved approve VBN cord-259957-temt8b6f 12 7 for for IN cord-259957-temt8b6f 12 8 the the DT cord-259957-temt8b6f 12 9 prevention prevention NN cord-259957-temt8b6f 12 10 and and CC cord-259957-temt8b6f 12 11 treatment treatment NN cord-259957-temt8b6f 12 12 of of IN cord-259957-temt8b6f 12 13 malaria malaria NN cord-259957-temt8b6f 12 14 . . . cord-259957-temt8b6f 13 1 However however RB cord-259957-temt8b6f 13 2 , , , cord-259957-temt8b6f 13 3 it -PRON- PRP cord-259957-temt8b6f 13 4 is be VBZ cord-259957-temt8b6f 13 5 utilized utilize VBN cord-259957-temt8b6f 13 6 extensively extensively RB cord-259957-temt8b6f 13 7 by by IN cord-259957-temt8b6f 13 8 both both DT cord-259957-temt8b6f 13 9 physicians physician NNS cord-259957-temt8b6f 13 10 and and CC cord-259957-temt8b6f 13 11 dentists dentist NNS cord-259957-temt8b6f 13 12 ( ( -LRB- cord-259957-temt8b6f 13 13 oral oral JJ cord-259957-temt8b6f 13 14 medicine medicine NN cord-259957-temt8b6f 13 15 clinicians clinician NNS cord-259957-temt8b6f 13 16 ) ) -RRB- cord-259957-temt8b6f 13 17 in in IN cord-259957-temt8b6f 13 18 the the DT cord-259957-temt8b6f 13 19 treatment treatment NN cord-259957-temt8b6f 13 20 of of IN cord-259957-temt8b6f 13 21 rheumatologic rheumatologic JJ cord-259957-temt8b6f 13 22 conditions condition NNS cord-259957-temt8b6f 13 23 , , , cord-259957-temt8b6f 13 24 such such JJ cord-259957-temt8b6f 13 25 as as IN cord-259957-temt8b6f 13 26 systemic systemic JJ cord-259957-temt8b6f 13 27 lupus lupus NN cord-259957-temt8b6f 13 28 erythematosus erythematosus NN cord-259957-temt8b6f 13 29 , , , cord-259957-temt8b6f 13 30 Sjogren Sjogren NNP cord-259957-temt8b6f 13 31 syndrome syndrome NN cord-259957-temt8b6f 13 32 , , , cord-259957-temt8b6f 13 33 rheumatoid rheumatoid NN cord-259957-temt8b6f 13 34 arthritis arthritis NN cord-259957-temt8b6f 13 35 , , , cord-259957-temt8b6f 13 36 chronic chronic JJ cord-259957-temt8b6f 13 37 ulcerative ulcerative JJ cord-259957-temt8b6f 13 38 stomatitis stomatitis NN cord-259957-temt8b6f 13 39 , , , cord-259957-temt8b6f 13 40 immune immune JJ cord-259957-temt8b6f 13 41 thrombocytopenia thrombocytopenia NN cord-259957-temt8b6f 13 42 purpura purpura NN cord-259957-temt8b6f 13 43 , , , cord-259957-temt8b6f 13 44 lichen lichen NN cord-259957-temt8b6f 13 45 planopilaris planopilaris NN cord-259957-temt8b6f 13 46 , , , cord-259957-temt8b6f 13 47 and and CC cord-259957-temt8b6f 13 48 oral oral JJ cord-259957-temt8b6f 13 49 lichen lichen NN cord-259957-temt8b6f 13 50 planus planus NN cord-259957-temt8b6f 13 51 . . . cord-259957-temt8b6f 14 1 In in IN cord-259957-temt8b6f 14 2 the the DT cord-259957-temt8b6f 14 3 realm realm NN cord-259957-temt8b6f 14 4 of of IN cord-259957-temt8b6f 14 5 treatment treatment NN cord-259957-temt8b6f 14 6 of of IN cord-259957-temt8b6f 14 7 autoimmune autoimmune JJ cord-259957-temt8b6f 14 8 secretory secretory JJ cord-259957-temt8b6f 14 9 and and CC cord-259957-temt8b6f 14 10 oral oral JJ cord-259957-temt8b6f 14 11 mucosal mucosal JJ cord-259957-temt8b6f 14 12 conditions condition NNS cord-259957-temt8b6f 14 13 , , , cord-259957-temt8b6f 14 14 HCQ HCQ NNP cord-259957-temt8b6f 14 15 has have VBZ cord-259957-temt8b6f 14 16 been be VBN cord-259957-temt8b6f 14 17 deemed deem VBN cord-259957-temt8b6f 14 18 safe safe JJ cord-259957-temt8b6f 14 19 and and CC cord-259957-temt8b6f 14 20 effective effective JJ cord-259957-temt8b6f 14 21 for for IN cord-259957-temt8b6f 14 22 such such JJ cord-259957-temt8b6f 14 23 oral oral JJ cord-259957-temt8b6f 14 24 conditions condition NNS cord-259957-temt8b6f 14 25 as as IN cord-259957-temt8b6f 14 26 Sjogren Sjogren NNP cord-259957-temt8b6f 14 27 syndrome syndrome NN cord-259957-temt8b6f 14 28 , , , cord-259957-temt8b6f 14 29 chronic chronic JJ cord-259957-temt8b6f 14 30 ulcerative ulcerative JJ cord-259957-temt8b6f 14 31 stomatitis stomatitis NN cord-259957-temt8b6f 14 32 , , , cord-259957-temt8b6f 14 33 and and CC cord-259957-temt8b6f 14 34 oral oral JJ cord-259957-temt8b6f 14 35 lichen lichen NN cord-259957-temt8b6f 14 36 planus planus NN cord-259957-temt8b6f 14 37 . . . cord-259957-temt8b6f 15 1 [ [ -LRB- cord-259957-temt8b6f 15 2 2 2 LS cord-259957-temt8b6f 15 3 ] ] -RRB- cord-259957-temt8b6f 15 4 [ [ -LRB- cord-259957-temt8b6f 15 5 3 3 CD cord-259957-temt8b6f 15 6 ] ] -RRB- cord-259957-temt8b6f 15 7 [ [ -LRB- cord-259957-temt8b6f 15 8 4 4 CD cord-259957-temt8b6f 15 9 ] ] -RRB- cord-259957-temt8b6f 15 10 [ [ -LRB- cord-259957-temt8b6f 15 11 5 5 CD cord-259957-temt8b6f 15 12 ] ] -RRB- cord-259957-temt8b6f 15 13 [ [ -LRB- cord-259957-temt8b6f 15 14 6 6 CD cord-259957-temt8b6f 15 15 ] ] -RRB- cord-259957-temt8b6f 15 16 [ [ -LRB- cord-259957-temt8b6f 15 17 7 7 CD cord-259957-temt8b6f 15 18 ] ] -RRB- cord-259957-temt8b6f 16 1 [ [ -LRB- cord-259957-temt8b6f 16 2 8 8 CD cord-259957-temt8b6f 16 3 ] ] -RRB- cord-259957-temt8b6f 16 4 [ [ -LRB- cord-259957-temt8b6f 16 5 9 9 CD cord-259957-temt8b6f 16 6 ] ] -RRB- cord-259957-temt8b6f 17 1 A a DT cord-259957-temt8b6f 17 2 noted noted JJ cord-259957-temt8b6f 17 3 possible possible JJ cord-259957-temt8b6f 17 4 negative negative JJ cord-259957-temt8b6f 17 5 effect effect NN cord-259957-temt8b6f 17 6 of of IN cord-259957-temt8b6f 17 7 HCQ HCQ NNP cord-259957-temt8b6f 17 8 is be VBZ cord-259957-temt8b6f 17 9 druginduced druginduced JJ cord-259957-temt8b6f 17 10 conjunctivitis conjunctivitis NN cord-259957-temt8b6f 17 11 . . . cord-259957-temt8b6f 18 1 This this DT cord-259957-temt8b6f 18 2 toxicity toxicity NN cord-259957-temt8b6f 18 3 is be VBZ cord-259957-temt8b6f 18 4 typically typically RB cord-259957-temt8b6f 18 5 addressed address VBN cord-259957-temt8b6f 18 6 by by IN cord-259957-temt8b6f 18 7 advising advise VBG cord-259957-temt8b6f 18 8 the the DT cord-259957-temt8b6f 18 9 patient patient NN cord-259957-temt8b6f 18 10 to to TO cord-259957-temt8b6f 18 11 see see VB cord-259957-temt8b6f 18 12 his -PRON- PRP$ cord-259957-temt8b6f 18 13 or or CC cord-259957-temt8b6f 18 14 her -PRON- PRP$ cord-259957-temt8b6f 18 15 ophthalmologist ophthalmologist NN cord-259957-temt8b6f 18 16 at at IN cord-259957-temt8b6f 18 17 least least JJS cord-259957-temt8b6f 18 18 once once RB cord-259957-temt8b6f 18 19 yearly yearly JJ cord-259957-temt8b6f 18 20 . . . cord-259957-temt8b6f 19 1 10 10 CD cord-259957-temt8b6f 20 1 Recently recently RB cord-259957-temt8b6f 20 2 , , , cord-259957-temt8b6f 20 3 it -PRON- PRP cord-259957-temt8b6f 20 4 has have VBZ cord-259957-temt8b6f 20 5 been be VBN cord-259957-temt8b6f 20 6 noted note VBN cord-259957-temt8b6f 20 7 that that IN cord-259957-temt8b6f 20 8 there there EX cord-259957-temt8b6f 20 9 is be VBZ cord-259957-temt8b6f 20 10 a a DT cord-259957-temt8b6f 20 11 rare rare JJ cord-259957-temt8b6f 20 12 complication complication NN cord-259957-temt8b6f 20 13 related relate VBN cord-259957-temt8b6f 20 14 to to IN cord-259957-temt8b6f 20 15 HCQ HCQ NNP cord-259957-temt8b6f 20 16 use use NN cord-259957-temt8b6f 20 17 , , , cord-259957-temt8b6f 20 18 that that RB cord-259957-temt8b6f 20 19 is is RB cord-259957-temt8b6f 20 20 , , , cord-259957-temt8b6f 20 21 sudden sudden JJ cord-259957-temt8b6f 20 22 death death NN cord-259957-temt8b6f 20 23 resulting result VBG cord-259957-temt8b6f 20 24 from from IN cord-259957-temt8b6f 20 25 a a DT cord-259957-temt8b6f 20 26 particular particular JJ cord-259957-temt8b6f 20 27 cardiac cardiac JJ cord-259957-temt8b6f 20 28 arrhythmia arrhythmia NN cord-259957-temt8b6f 20 29 . . . cord-259957-temt8b6f 21 1 Torsade Torsade NNP cord-259957-temt8b6f 21 2 de de IN cord-259957-temt8b6f 21 3 pointes pointes FW cord-259957-temt8b6f 21 4 arrhythmia arrhythmia NN cord-259957-temt8b6f 21 5 is be VBZ cord-259957-temt8b6f 21 6 associated associate VBN cord-259957-temt8b6f 21 7 with with IN cord-259957-temt8b6f 21 8 prolonged prolonged JJ cord-259957-temt8b6f 21 9 QT qt NN cord-259957-temt8b6f 21 10 duration duration NN cord-259957-temt8b6f 21 11 secondary secondary JJ cord-259957-temt8b6f 21 12 to to IN cord-259957-temt8b6f 21 13 high high JJ cord-259957-temt8b6f 21 14 - - HYPH cord-259957-temt8b6f 21 15 dose dose NN cord-259957-temt8b6f 21 16 HCQ HCQ NNP cord-259957-temt8b6f 21 17 administration administration NN cord-259957-temt8b6f 21 18 . . . cord-259957-temt8b6f 22 1 11 11 CD cord-259957-temt8b6f 22 2 , , , cord-259957-temt8b6f 22 3 12 12 CD cord-259957-temt8b6f 22 4 However however RB cord-259957-temt8b6f 22 5 , , , cord-259957-temt8b6f 22 6 as as IN cord-259957-temt8b6f 22 7 reported report VBN cord-259957-temt8b6f 22 8 by by IN cord-259957-temt8b6f 22 9 O'Laughlin O'Laughlin NNP cord-259957-temt8b6f 22 10 et et NNP cord-259957-temt8b6f 22 11 al al NNP cord-259957-temt8b6f 22 12 . . NNP cord-259957-temt8b6f 22 13 , , , cord-259957-temt8b6f 22 14 13 13 CD cord-259957-temt8b6f 22 15 HCQ hcq NN cord-259957-temt8b6f 22 16 - - HYPH cord-259957-temt8b6f 22 17 related relate VBN cord-259957-temt8b6f 22 18 QT qt NN cord-259957-temt8b6f 22 19 interval interval NN cord-259957-temt8b6f 22 20 prolongation prolongation NN cord-259957-temt8b6f 22 21 and and CC cord-259957-temt8b6f 22 22 secondary secondary JJ cord-259957-temt8b6f 22 23 arrhythmia arrhythmia NN cord-259957-temt8b6f 22 24 are be VBP cord-259957-temt8b6f 22 25 extremely extremely RB cord-259957-temt8b6f 22 26 rare rare JJ cord-259957-temt8b6f 22 27 and and CC cord-259957-temt8b6f 22 28 may may MD cord-259957-temt8b6f 22 29 be be VB cord-259957-temt8b6f 22 30 related relate VBN cord-259957-temt8b6f 22 31 to to IN cord-259957-temt8b6f 22 32 higher high JJR cord-259957-temt8b6f 22 33 dosage dosage NN cord-259957-temt8b6f 22 34 regimens regimen NNS cord-259957-temt8b6f 22 35 . . . cord-259957-temt8b6f 23 1 Danielsson Danielsson NNP cord-259957-temt8b6f 23 2 et et NNP cord-259957-temt8b6f 23 3 al al NNP cord-259957-temt8b6f 23 4 . . . cord-259957-temt8b6f 24 1 14 14 CD cord-259957-temt8b6f 24 2 reported report VBD cord-259957-temt8b6f 24 3 that that IN cord-259957-temt8b6f 24 4 the the DT cord-259957-temt8b6f 24 5 results result NNS cord-259957-temt8b6f 24 6 of of IN cord-259957-temt8b6f 24 7 their -PRON- PRP$ cord-259957-temt8b6f 24 8 recent recent JJ cord-259957-temt8b6f 24 9 study study NN cord-259957-temt8b6f 24 10 on on IN cord-259957-temt8b6f 24 11 sudden sudden JJ cord-259957-temt8b6f 24 12 death death NN cord-259957-temt8b6f 24 13 in in IN cord-259957-temt8b6f 24 14 older old JJR cord-259957-temt8b6f 24 15 patients patient NNS cord-259957-temt8b6f 24 16 indicated indicate VBD cord-259957-temt8b6f 24 17 an an DT cord-259957-temt8b6f 24 18 increased increase VBN cord-259957-temt8b6f 24 19 risk risk NN cord-259957-temt8b6f 24 20 of of IN cord-259957-temt8b6f 24 21 torsade torsade NNP cord-259957-temt8b6f 24 22 de de FW cord-259957-temt8b6f 24 23 pointes pointes NNP cord-259957-temt8b6f 24 24 arrhythmia arrhythmia NN cord-259957-temt8b6f 24 25 with with IN cord-259957-temt8b6f 24 26 the the DT cord-259957-temt8b6f 24 27 use use NN cord-259957-temt8b6f 24 28 of of IN cord-259957-temt8b6f 24 29 the the DT cord-259957-temt8b6f 24 30 selective selective JJ cord-259957-temt8b6f 24 31 serotonin serotonin NN cord-259957-temt8b6f 24 32 reuptake reuptake JJ cord-259957-temt8b6f 24 33 inhibitor inhibitor NN cord-259957-temt8b6f 24 34 citalopram citalopram NNP cord-259957-temt8b6f 24 35 . . . cord-259957-temt8b6f 25 1 Therefore therefore RB cord-259957-temt8b6f 25 2 , , , cord-259957-temt8b6f 25 3 there there EX cord-259957-temt8b6f 25 4 appears appear VBZ cord-259957-temt8b6f 25 5 to to TO cord-259957-temt8b6f 25 6 be be VB cord-259957-temt8b6f 25 7 the the DT cord-259957-temt8b6f 25 8 possibility possibility NN cord-259957-temt8b6f 25 9 of of IN cord-259957-temt8b6f 25 10 additive additive NN cord-259957-temt8b6f 25 11 drug drug NN cord-259957-temt8b6f 25 12 interactions interaction NNS cord-259957-temt8b6f 25 13 when when WRB cord-259957-temt8b6f 25 14 prescribing prescribe VBG cord-259957-temt8b6f 25 15 HCQ HCQ NNP cord-259957-temt8b6f 25 16 to to IN cord-259957-temt8b6f 25 17 patients patient NNS cord-259957-temt8b6f 25 18 already already RB cord-259957-temt8b6f 25 19 taking take VBG cord-259957-temt8b6f 25 20 citalopram citalopram NNP cord-259957-temt8b6f 25 21 and and CC cord-259957-temt8b6f 25 22 other other JJ cord-259957-temt8b6f 25 23 drugs drug NNS cord-259957-temt8b6f 25 24 that that WDT cord-259957-temt8b6f 25 25 significantly significantly RB cord-259957-temt8b6f 25 26 prolong prolong VBP cord-259957-temt8b6f 25 27 the the DT cord-259957-temt8b6f 25 28 QT qt NN cord-259957-temt8b6f 25 29 duration duration NN cord-259957-temt8b6f 25 30 and and CC cord-259957-temt8b6f 25 31 increase increase VB cord-259957-temt8b6f 25 32 the the DT cord-259957-temt8b6f 25 33 risk risk NN cord-259957-temt8b6f 25 34 of of IN cord-259957-temt8b6f 25 35 a a DT cord-259957-temt8b6f 25 36 torsade torsade NNP cord-259957-temt8b6f 25 37 de de FW cord-259957-temt8b6f 25 38 pointes pointes FW cord-259957-temt8b6f 25 39 arrhythmia arrhythmia NN cord-259957-temt8b6f 25 40 . . . cord-259957-temt8b6f 26 1 15 15 CD cord-259957-temt8b6f 26 2 Over over IN cord-259957-temt8b6f 26 3 20 20 CD cord-259957-temt8b6f 26 4 years year NNS cord-259957-temt8b6f 26 5 ago ago RB cord-259957-temt8b6f 26 6 , , , cord-259957-temt8b6f 26 7 it -PRON- PRP cord-259957-temt8b6f 26 8 was be VBD cord-259957-temt8b6f 26 9 noted note VBN cord-259957-temt8b6f 26 10 that that IN cord-259957-temt8b6f 26 11 the the DT cord-259957-temt8b6f 26 12 antihistamine antihistamine NN cord-259957-temt8b6f 26 13 H1 H1 NNP cord-259957-temt8b6f 26 14 blocker blocker NN cord-259957-temt8b6f 26 15 terfenadine terfenadine NNP cord-259957-temt8b6f 26 16 was be VBD cord-259957-temt8b6f 26 17 cardiotoxic cardiotoxic JJ cord-259957-temt8b6f 26 18 in in IN cord-259957-temt8b6f 26 19 higher high JJR cord-259957-temt8b6f 26 20 doses dose NNS cord-259957-temt8b6f 26 21 and and CC cord-259957-temt8b6f 26 22 that that IN cord-259957-temt8b6f 26 23 particular particular JJ cord-259957-temt8b6f 26 24 drugs drug NNS cord-259957-temt8b6f 26 25 used use VBN cord-259957-temt8b6f 26 26 in in IN cord-259957-temt8b6f 26 27 dentistry dentistry NN cord-259957-temt8b6f 26 28 , , , cord-259957-temt8b6f 26 29 such such JJ cord-259957-temt8b6f 26 30 as as IN cord-259957-temt8b6f 26 31 ketoconazole ketoconazole NNP cord-259957-temt8b6f 26 32 and and CC cord-259957-temt8b6f 26 33 erythromycin erythromycin NN cord-259957-temt8b6f 26 34 , , , cord-259957-temt8b6f 26 35 and and CC cord-259957-temt8b6f 26 36 even even RB cord-259957-temt8b6f 26 37 grapefruit grapefruit NN cord-259957-temt8b6f 26 38 juice juice NN cord-259957-temt8b6f 26 39 could could MD cord-259957-temt8b6f 26 40 result result VB cord-259957-temt8b6f 26 41 in in IN cord-259957-temt8b6f 26 42 a a DT cord-259957-temt8b6f 26 43 drugÀdrug drugàdrug JJ cord-259957-temt8b6f 26 44 interaction interaction NN cord-259957-temt8b6f 26 45 and and CC cord-259957-temt8b6f 26 46 potentially potentially RB cord-259957-temt8b6f 26 47 lethal lethal JJ cord-259957-temt8b6f 26 48 serum serum NN cord-259957-temt8b6f 26 49 values value NNS cord-259957-temt8b6f 26 50 , , , cord-259957-temt8b6f 26 51 with with IN cord-259957-temt8b6f 26 52 the the DT cord-259957-temt8b6f 26 53 possible possible JJ cord-259957-temt8b6f 26 54 result result NN cord-259957-temt8b6f 26 55 of of IN cord-259957-temt8b6f 26 56 cardiotoxicity cardiotoxicity NN cord-259957-temt8b6f 26 57 ( ( -LRB- cord-259957-temt8b6f 26 58 specifically specifically RB cord-259957-temt8b6f 26 59 the the DT cord-259957-temt8b6f 26 60 torsade torsade NNP cord-259957-temt8b6f 26 61 de de FW cord-259957-temt8b6f 26 62 pointes pointes NNP cord-259957-temt8b6f 26 63 arrhythmia arrhythmia NN cord-259957-temt8b6f 26 64 ) ) -RRB- cord-259957-temt8b6f 26 65 and and CC cord-259957-temt8b6f 26 66 death death NN cord-259957-temt8b6f 26 67 . . . cord-259957-temt8b6f 27 1 The the DT cord-259957-temt8b6f 27 2 danger danger NN cord-259957-temt8b6f 27 3 of of IN cord-259957-temt8b6f 27 4 this this DT cord-259957-temt8b6f 27 5 sudden sudden JJ cord-259957-temt8b6f 27 6 death death NN cord-259957-temt8b6f 27 7 condition condition NN cord-259957-temt8b6f 27 8 resulted result VBD cord-259957-temt8b6f 27 9 in in IN cord-259957-temt8b6f 27 10 the the DT cord-259957-temt8b6f 27 11 eventual eventual JJ cord-259957-temt8b6f 27 12 removal removal NN cord-259957-temt8b6f 27 13 of of IN cord-259957-temt8b6f 27 14 terfenadine terfenadine NN cord-259957-temt8b6f 27 15 as as IN cord-259957-temt8b6f 27 16 a a DT cord-259957-temt8b6f 27 17 clinical clinical JJ cord-259957-temt8b6f 27 18 therapeutic therapeutic JJ cord-259957-temt8b6f 27 19 agent agent NN cord-259957-temt8b6f 27 20 worldwide worldwide RB cord-259957-temt8b6f 27 21 . . . cord-259957-temt8b6f 28 1 [ [ -LRB- cord-259957-temt8b6f 28 2 16 16 CD cord-259957-temt8b6f 28 3 ] ] -RRB- cord-259957-temt8b6f 28 4 [ [ -LRB- cord-259957-temt8b6f 28 5 17 17 CD cord-259957-temt8b6f 28 6 ] ] -RRB- cord-259957-temt8b6f 28 7 [ [ -LRB- cord-259957-temt8b6f 28 8 18 18 CD cord-259957-temt8b6f 28 9 ] ] -RRB- cord-259957-temt8b6f 29 1 [ [ -LRB- cord-259957-temt8b6f 29 2 19 19 CD cord-259957-temt8b6f 29 3 ] ] -RRB- cord-259957-temt8b6f 30 1 At at IN cord-259957-temt8b6f 30 2 rheumatologic rheumatologic JJ cord-259957-temt8b6f 30 3 therapeutic therapeutic JJ cord-259957-temt8b6f 30 4 dosage dosage NN cord-259957-temt8b6f 30 5 levels level NNS cord-259957-temt8b6f 30 6 , , , cord-259957-temt8b6f 30 7 HCQ HCQ NNP cord-259957-temt8b6f 30 8 has have VBZ cord-259957-temt8b6f 30 9 been be VBN cord-259957-temt8b6f 30 10 regarded regard VBN cord-259957-temt8b6f 30 11 as as IN cord-259957-temt8b6f 30 12 a a DT cord-259957-temt8b6f 30 13 reasonably reasonably RB cord-259957-temt8b6f 30 14 safe safe JJ cord-259957-temt8b6f 30 15 therapeutic therapeutic JJ cord-259957-temt8b6f 30 16 agent agent NN cord-259957-temt8b6f 30 17 . . . cord-259957-temt8b6f 31 1 However however RB cord-259957-temt8b6f 31 2 , , , cord-259957-temt8b6f 31 3 oral oral JJ cord-259957-temt8b6f 31 4 medicine medicine NN cord-259957-temt8b6f 31 5 clinicians clinician NNS cord-259957-temt8b6f 31 6 and and CC cord-259957-temt8b6f 31 7 other other JJ cord-259957-temt8b6f 31 8 health health NN cord-259957-temt8b6f 31 9 care care NN cord-259957-temt8b6f 31 10 providers provider NNS cord-259957-temt8b6f 31 11 should should MD cord-259957-temt8b6f 31 12 be be VB cord-259957-temt8b6f 31 13 advised advise VBN cord-259957-temt8b6f 31 14 of of IN cord-259957-temt8b6f 31 15 the the DT cord-259957-temt8b6f 31 16 potential potential JJ cord-259957-temt8b6f 31 17 issues issue NNS cord-259957-temt8b6f 31 18 with with IN cord-259957-temt8b6f 31 19 the the DT cord-259957-temt8b6f 31 20 use use NN cord-259957-temt8b6f 31 21 of of IN cord-259957-temt8b6f 31 22 HCQ HCQ NNP cord-259957-temt8b6f 31 23 , , , cord-259957-temt8b6f 31 24 such such JJ cord-259957-temt8b6f 31 25 as as IN cord-259957-temt8b6f 31 26 drugÀdrug drugàdrug JJ cord-259957-temt8b6f 31 27 interactions interaction NNS cord-259957-temt8b6f 31 28 , , , cord-259957-temt8b6f 31 29 the the DT cord-259957-temt8b6f 31 30 additive additive NN cord-259957-temt8b6f 31 31 toxicity toxicity NN cord-259957-temt8b6f 31 32 of of IN cord-259957-temt8b6f 31 33 QT qt NN cord-259957-temt8b6f 31 34 duration duration NN cord-259957-temt8b6f 31 35 prolongation prolongation NN cord-259957-temt8b6f 31 36 , , , cord-259957-temt8b6f 31 37 and and CC cord-259957-temt8b6f 31 38 the the DT cord-259957-temt8b6f 31 39 association association NN cord-259957-temt8b6f 31 40 with with IN cord-259957-temt8b6f 31 41 sudden sudden JJ cord-259957-temt8b6f 31 42 death death NN cord-259957-temt8b6f 31 43 , , , cord-259957-temt8b6f 31 44 in in IN cord-259957-temt8b6f 31 45 the the DT cord-259957-temt8b6f 31 46 treatment treatment NN cord-259957-temt8b6f 31 47 of of IN cord-259957-temt8b6f 31 48 older old JJR cord-259957-temt8b6f 31 49 patients patient NNS cord-259957-temt8b6f 31 50 . . . cord-259957-temt8b6f 31 51 _SP cord-259957-temt8b6f 32 1 Could Could MD cord-259957-temt8b6f 32 2 the the DT cord-259957-temt8b6f 32 3 anti anti JJ cord-259957-temt8b6f 32 4 - - JJ cord-259957-temt8b6f 32 5 malarial malarial JJ cord-259957-temt8b6f 32 6 drug drug NN cord-259957-temt8b6f 32 7 chloroquine chloroquine NNP cord-259957-temt8b6f 32 8 treat treat NNP cord-259957-temt8b6f 32 9 COVID-19 COVID-19 NNP cord-259957-temt8b6f 32 10 ? ? . cord-259957-temt8b6f 33 1 Available available JJ cord-259957-temt8b6f 33 2 at at IN cord-259957-temt8b6f 33 3 Bhattacharyya Bhattacharyya NNP cord-259957-temt8b6f 33 4 I. I. NNP cord-259957-temt8b6f 33 5 Chronic Chronic NNP cord-259957-temt8b6f 33 6 ulcerative ulcerative JJ cord-259957-temt8b6f 33 7 stomatitis stomatitis NN cord-259957-temt8b6f 33 8 : : : cord-259957-temt8b6f 33 9 diagnostic diagnostic JJ cord-259957-temt8b6f 33 10 and and CC cord-259957-temt8b6f 33 11 management management NN cord-259957-temt8b6f 33 12 challenges challenge NNS cord-259957-temt8b6f 33 13 - - : cord-259957-temt8b6f 33 14 four four CD cord-259957-temt8b6f 33 15 new new JJ cord-259957-temt8b6f 33 16 cases case NNS cord-259957-temt8b6f 33 17 and and CC cord-259957-temt8b6f 33 18 review review NN cord-259957-temt8b6f 33 19 of of IN cord-259957-temt8b6f 33 20 literature literature NN cord-259957-temt8b6f 33 21 . . . cord-259957-temt8b6f 34 1 Oral oral JJ cord-259957-temt8b6f 34 2 Surg Surg NNP cord-259957-temt8b6f 34 3 Oral Oral NNP cord-259957-temt8b6f 34 4 Med Med NNP cord-259957-temt8b6f 34 5 Oral oral JJ cord-259957-temt8b6f 34 6 Pathol Pathol NNP cord-259957-temt8b6f 34 7 Oral Oral NNP cord-259957-temt8b6f 34 8 Radiol Radiol NNP cord-259957-temt8b6f 34 9 Endod Endod NNP cord-259957-temt8b6f 34 10 Metabolic Metabolic NNP cord-259957-temt8b6f 34 11 and and CC cord-259957-temt8b6f 34 12 cardiovascular cardiovascular JJ cord-259957-temt8b6f 34 13 benefits benefit NNS cord-259957-temt8b6f 34 14 of of IN cord-259957-temt8b6f 34 15 hydroxychloroquine hydroxychloroquine NN cord-259957-temt8b6f 34 16 in in IN cord-259957-temt8b6f 34 17 patients patient NNS cord-259957-temt8b6f 34 18 with with IN cord-259957-temt8b6f 34 19 rheumatoid rheumatoid NN cord-259957-temt8b6f 34 20 arthritis arthritis NN cord-259957-temt8b6f 34 21 : : : cord-259957-temt8b6f 34 22 a a DT cord-259957-temt8b6f 34 23 systematic systematic JJ cord-259957-temt8b6f 34 24 review review NN cord-259957-temt8b6f 34 25 and and CC cord-259957-temt8b6f 34 26 meta meta NNP cord-259957-temt8b6f 34 27 - - HYPH cord-259957-temt8b6f 34 28 analysis analysis NN cord-259957-temt8b6f 34 29 Chronic Chronic NNP cord-259957-temt8b6f 34 30 ulcerative ulcerative JJ cord-259957-temt8b6f 34 31 stomatitis stomatitis NN cord-259957-temt8b6f 34 32 : : : cord-259957-temt8b6f 34 33 a a DT cord-259957-temt8b6f 34 34 distinct distinct JJ cord-259957-temt8b6f 34 35 clinical clinical JJ cord-259957-temt8b6f 34 36 entity entity NN cord-259957-temt8b6f 34 37 Effects effect NNS cord-259957-temt8b6f 34 38 of of IN cord-259957-temt8b6f 34 39 hydroxychlorquine hydroxychlorquine NN cord-259957-temt8b6f 34 40 on on IN cord-259957-temt8b6f 34 41 salivary salivary JJ cord-259957-temt8b6f 34 42 flow flow NN cord-259957-temt8b6f 34 43 rates rate NNS cord-259957-temt8b6f 34 44 and and CC cord-259957-temt8b6f 34 45 oral oral JJ cord-259957-temt8b6f 34 46 complaints complaint NNS cord-259957-temt8b6f 34 47 of of IN cord-259957-temt8b6f 34 48 Sjogren Sjogren NNP cord-259957-temt8b6f 34 49 patients patient NNS cord-259957-temt8b6f 34 50 : : : cord-259957-temt8b6f 34 51 a a DT cord-259957-temt8b6f 34 52 prospective prospective JJ cord-259957-temt8b6f 34 53 Ó Ó NNP cord-259957-temt8b6f 34 54 Hydroxychloroquine Hydroxychloroquine NNP cord-259957-temt8b6f 34 55 : : : cord-259957-temt8b6f 34 56 a a DT cord-259957-temt8b6f 34 57 multifaceted multifaceted JJ cord-259957-temt8b6f 34 58 treatment treatment NN cord-259957-temt8b6f 34 59 in in IN cord-259957-temt8b6f 34 60 lupus lupus NN cord-259957-temt8b6f 35 1 The the DT cord-259957-temt8b6f 35 2 role role NN cord-259957-temt8b6f 35 3 of of IN cord-259957-temt8b6f 35 4 hydroxychloroquine hydroxychloroquine NN cord-259957-temt8b6f 35 5 as as IN cord-259957-temt8b6f 35 6 a a DT cord-259957-temt8b6f 35 7 steroid steroid NN cord-259957-temt8b6f 35 8 - - HYPH cord-259957-temt8b6f 35 9 sparing spare VBG cord-259957-temt8b6f 35 10 agent agent NN cord-259957-temt8b6f 35 11 in in IN cord-259957-temt8b6f 35 12 the the DT cord-259957-temt8b6f 35 13 treatment treatment NN cord-259957-temt8b6f 35 14 of of IN cord-259957-temt8b6f 35 15 immune immune JJ cord-259957-temt8b6f 35 16 thrombocytopenia thrombocytopenia NN cord-259957-temt8b6f 35 17 : : : cord-259957-temt8b6f 35 18 a a DT cord-259957-temt8b6f 35 19 review review NN cord-259957-temt8b6f 35 20 of of IN cord-259957-temt8b6f 35 21 the the DT cord-259957-temt8b6f 35 22 literature literature NN cord-259957-temt8b6f 35 23 Hydroxychloroquine Hydroxychloroquine NNP cord-259957-temt8b6f 35 24 and and CC cord-259957-temt8b6f 35 25 lichen lichen NNP cord-259957-temt8b6f 35 26 planopilaris planopilaris NNP cord-259957-temt8b6f 35 27 : : : cord-259957-temt8b6f 35 28 efficacy efficacy NN cord-259957-temt8b6f 35 29 and and CC cord-259957-temt8b6f 35 30 introduction introduction NN cord-259957-temt8b6f 35 31 of of IN cord-259957-temt8b6f 35 32 Lichen Lichen NNP cord-259957-temt8b6f 35 33 Planopilaris Planopilaris NNP cord-259957-temt8b6f 35 34 Activity Activity NNP cord-259957-temt8b6f 35 35 Index Index NNP cord-259957-temt8b6f 35 36 scoring scoring NN cord-259957-temt8b6f 35 37 system system NN cord-259957-temt8b6f 35 38 Hydroxychloroquine Hydroxychloroquine NNP cord-259957-temt8b6f 35 39 sulphate sulphate NN cord-259957-temt8b6f 35 40 therapy therapy NN cord-259957-temt8b6f 35 41 of of IN cord-259957-temt8b6f 35 42 erosive erosive JJ cord-259957-temt8b6f 35 43 oral oral JJ cord-259957-temt8b6f 35 44 lichen lichen NN cord-259957-temt8b6f 35 45 planus planus NN cord-259957-temt8b6f 35 46 . . . cord-259957-temt8b6f 36 1 Australas Australas NNP cord-259957-temt8b6f 36 2 Ocular ocular JJ cord-259957-temt8b6f 36 3 adverse adverse JJ cord-259957-temt8b6f 36 4 effects effect NNS cord-259957-temt8b6f 36 5 associated associate VBN cord-259957-temt8b6f 36 6 with with IN cord-259957-temt8b6f 36 7 systemic systemic JJ cord-259957-temt8b6f 36 8 medications medication NNS cord-259957-temt8b6f 36 9 : : : cord-259957-temt8b6f 36 10 recognition recognition NN cord-259957-temt8b6f 36 11 and and CC cord-259957-temt8b6f 36 12 management management NN cord-259957-temt8b6f 36 13 Chronic Chronic NNP cord-259957-temt8b6f 36 14 hydroxychloroquine hydroxychloroquine NN cord-259957-temt8b6f 36 15 use use NN cord-259957-temt8b6f 36 16 associated associate VBN cord-259957-temt8b6f 36 17 with with IN cord-259957-temt8b6f 36 18 QT qt NN cord-259957-temt8b6f 36 19 prolongation prolongation NN cord-259957-temt8b6f 36 20 and and CC cord-259957-temt8b6f 36 21 refractory refractory JJ cord-259957-temt8b6f 36 22 ventricular ventricular JJ cord-259957-temt8b6f 36 23 arrhythmia arrhythmia NN cord-259957-temt8b6f 36 24 Cardiac cardiac JJ cord-259957-temt8b6f 36 25 complications complication NNS cord-259957-temt8b6f 36 26 attributed attribute VBN cord-259957-temt8b6f 36 27 to to IN cord-259957-temt8b6f 36 28 chloroquine chloroquine NN cord-259957-temt8b6f 36 29 and and CC cord-259957-temt8b6f 36 30 hydroxychloroquine hydroxychloroquine NN cord-259957-temt8b6f 36 31 : : : cord-259957-temt8b6f 36 32 a a DT cord-259957-temt8b6f 36 33 systematic systematic JJ cord-259957-temt8b6f 36 34 review review NN cord-259957-temt8b6f 36 35 of of IN cord-259957-temt8b6f 36 36 the the DT cord-259957-temt8b6f 36 37 literature literature NN cord-259957-temt8b6f 36 38 Life life NN cord-259957-temt8b6f 36 39 threatening threaten VBG cord-259957-temt8b6f 36 40 severe severe JJ cord-259957-temt8b6f 36 41 QTc qtc NN cord-259957-temt8b6f 36 42 prolongation prolongation NN cord-259957-temt8b6f 36 43 in in IN cord-259957-temt8b6f 36 44 patient patient NN cord-259957-temt8b6f 36 45 with with IN cord-259957-temt8b6f 36 46 systemic systemic JJ cord-259957-temt8b6f 36 47 lupus lupus NN cord-259957-temt8b6f 36 48 erythematosus erythematosus NN cord-259957-temt8b6f 36 49 due due IN cord-259957-temt8b6f 36 50 to to IN cord-259957-temt8b6f 36 51 hydroxychloroquine hydroxychloroquine VB cord-259957-temt8b6f 36 52 Drug Drug NNP cord-259957-temt8b6f 36 53 use use NN cord-259957-temt8b6f 36 54 and and CC cord-259957-temt8b6f 36 55 torsades torsades NNP cord-259957-temt8b6f 36 56 de de FW cord-259957-temt8b6f 36 57 pointes pointes FW cord-259957-temt8b6f 36 58 cardiac cardiac JJ cord-259957-temt8b6f 36 59 arrhythmias arrhythmia NNS cord-259957-temt8b6f 36 60 in in IN cord-259957-temt8b6f 36 61 Sweden Sweden NNP cord-259957-temt8b6f 36 62 : : : cord-259957-temt8b6f 37 1 a a DT cord-259957-temt8b6f 37 2 nationwide nationwide JJ cord-259957-temt8b6f 37 3 registerbased registerbase VBN cord-259957-temt8b6f 37 4 cohort cohort NN cord-259957-temt8b6f 37 5 study study NN cord-259957-temt8b6f 38 1 The the DT cord-259957-temt8b6f 38 2 role role NN cord-259957-temt8b6f 38 3 of of IN cord-259957-temt8b6f 38 4 adenosine adenosine NN cord-259957-temt8b6f 38 5 receptors receptor NNS cord-259957-temt8b6f 38 6 and and CC cord-259957-temt8b6f 38 7 endogenous endogenous JJ cord-259957-temt8b6f 38 8 adenosine adenosine NN cord-259957-temt8b6f 38 9 in in IN cord-259957-temt8b6f 38 10 citalopram citalopram NN cord-259957-temt8b6f 38 11 - - HYPH cord-259957-temt8b6f 38 12 induced induce VBN cord-259957-temt8b6f 38 13 cardiovascular cardiovascular JJ cord-259957-temt8b6f 38 14 toxicity toxicity NN cord-259957-temt8b6f 38 15 Grapefruit Grapefruit NNP cord-259957-temt8b6f 38 16 juice juice NN cord-259957-temt8b6f 38 17 alters alter VBZ cord-259957-temt8b6f 38 18 terfenadine terfenadine NNP cord-259957-temt8b6f 38 19 pharmacokinetics pharmacokinetics NNP cord-259957-temt8b6f 38 20 , , , cord-259957-temt8b6f 38 21 resulting result VBG cord-259957-temt8b6f 38 22 in in IN cord-259957-temt8b6f 38 23 prolongation prolongation NN cord-259957-temt8b6f 38 24 of of IN cord-259957-temt8b6f 38 25 repolarization repolarization NN cord-259957-temt8b6f 38 26 on on IN cord-259957-temt8b6f 38 27 the the DT cord-259957-temt8b6f 38 28 electrocardiogram electrocardiogram JJ cord-259957-temt8b6f 38 29 Cardiotoxicity Cardiotoxicity NNP cord-259957-temt8b6f 38 30 of of IN cord-259957-temt8b6f 38 31 histamine histamine NN cord-259957-temt8b6f 38 32 and and CC cord-259957-temt8b6f 38 33 the the DT cord-259957-temt8b6f 38 34 possible possible JJ cord-259957-temt8b6f 38 35 role role NN cord-259957-temt8b6f 38 36 of of IN cord-259957-temt8b6f 38 37 histamine histamine NN cord-259957-temt8b6f 38 38 in in IN cord-259957-temt8b6f 38 39 the the DT cord-259957-temt8b6f 38 40 arrhythmogenesis arrhythmogenesis NN cord-259957-temt8b6f 38 41 produced produce VBN cord-259957-temt8b6f 38 42 by by IN cord-259957-temt8b6f 38 43 certain certain JJ cord-259957-temt8b6f 38 44 antihistamines antihistamine NNS cord-259957-temt8b6f 38 45 Cardiac Cardiac NNP cord-259957-temt8b6f 38 46 K+ k+ JJ cord-259957-temt8b6f 38 47 channels channel NNS cord-259957-temt8b6f 38 48 and and CC cord-259957-temt8b6f 38 49 drug drug NN cord-259957-temt8b6f 38 50 - - HYPH cord-259957-temt8b6f 38 51 acquired acquire VBN cord-259957-temt8b6f 38 52 long long JJ cord-259957-temt8b6f 38 53 QT qt NN cord-259957-temt8b6f 38 54 syndrome syndrome NN cord-259957-temt8b6f 39 1 Next next JJ cord-259957-temt8b6f 39 2 generation generation NN cord-259957-temt8b6f 39 3 antihistamines antihistamine NNS cord-259957-temt8b6f 39 4 : : : cord-259957-temt8b6f 39 5 therapeutic therapeutic JJ cord-259957-temt8b6f 39 6 rationale rationale NN cord-259957-temt8b6f 39 7 , , , cord-259957-temt8b6f 39 8 accomplishments accomplishment NNS cord-259957-temt8b6f 39 9 and and CC cord-259957-temt8b6f 39 10 advances advance NNS