id sid tid token lemma pos cord-277555-tsd6npma 1 1 key key NN cord-277555-tsd6npma 1 2 : : : cord-277555-tsd6npma 1 3 cord-277555-tsd6npma cord-277555-tsd6npma NNS cord-277555-tsd6npma 1 4 authors author NNS cord-277555-tsd6npma 1 5 : : : cord-277555-tsd6npma 1 6 Wilde Wilde NNP cord-277555-tsd6npma 1 7 , , , cord-277555-tsd6npma 1 8 A. a. NN cord-277555-tsd6npma 1 9 A. a. NN cord-277555-tsd6npma 1 10 M. M. NNP cord-277555-tsd6npma 1 11 ; ; : cord-277555-tsd6npma 1 12 Offerhaus Offerhaus NNP cord-277555-tsd6npma 1 13 , , , cord-277555-tsd6npma 1 14 J. J. NNP cord-277555-tsd6npma 1 15 A. a. NN cord-277555-tsd6npma 1 16 title title NN cord-277555-tsd6npma 1 17 : : : cord-277555-tsd6npma 1 18 The the DT cord-277555-tsd6npma 1 19 ‘ ' `` cord-277555-tsd6npma 1 20 president president NNP cord-277555-tsd6npma 1 21 ’s ’s POS cord-277555-tsd6npma 1 22 drug drug NN cord-277555-tsd6npma 1 23 ’ ' '' cord-277555-tsd6npma 1 24 date date NN cord-277555-tsd6npma 1 25 : : : cord-277555-tsd6npma 1 26 2020 2020 CD cord-277555-tsd6npma 1 27 - - HYPH cord-277555-tsd6npma 1 28 07 07 CD cord-277555-tsd6npma 1 29 - - SYM cord-277555-tsd6npma 1 30 10 10 CD cord-277555-tsd6npma 1 31 journal journal NN cord-277555-tsd6npma 1 32 : : : cord-277555-tsd6npma 2 1 Neth Neth NNP cord-277555-tsd6npma 2 2 Heart Heart NNP cord-277555-tsd6npma 2 3 J J NNP cord-277555-tsd6npma 2 4 DOI DOI NNP cord-277555-tsd6npma 2 5 : : : cord-277555-tsd6npma 3 1 10.1007 10.1007 CD cord-277555-tsd6npma 3 2 / / SYM cord-277555-tsd6npma 3 3 s12471 s12471 NN cord-277555-tsd6npma 3 4 - - HYPH cord-277555-tsd6npma 3 5 020 020 CD cord-277555-tsd6npma 3 6 - - HYPH cord-277555-tsd6npma 3 7 01441-x 01441-x ADD cord-277555-tsd6npma 4 1 sha sha NNP cord-277555-tsd6npma 4 2 : : : cord-277555-tsd6npma 5 1 26729f8efc08cc472b6f64cb5064f3a35d6bac06 26729f8efc08cc472b6f64cb5064f3a35d6bac06 CD cord-277555-tsd6npma 5 2 doc_id doc_id CD cord-277555-tsd6npma 5 3 : : : cord-277555-tsd6npma 6 1 277555 277555 CD cord-277555-tsd6npma 6 2 cord_uid cord_uid NNS cord-277555-tsd6npma 6 3 : : : cord-277555-tsd6npma 7 1 tsd6npma tsd6npma NNP cord-277555-tsd6npma 7 2 nan nan NNP cord-277555-tsd6npma 8 1 The the DT cord-277555-tsd6npma 8 2 ongoing ongoing JJ cord-277555-tsd6npma 8 3 SARS SARS NNP cord-277555-tsd6npma 8 4 - - HYPH cord-277555-tsd6npma 8 5 CoV-2 CoV-2 NNP cord-277555-tsd6npma 8 6 pandemic pandemic NN cord-277555-tsd6npma 8 7 and and CC cord-277555-tsd6npma 8 8 the the DT cord-277555-tsd6npma 8 9 associated associate VBN cord-277555-tsd6npma 8 10 lung lung NNP cord-277555-tsd6npma 8 11 disease disease NNP cord-277555-tsd6npma 8 12 COVID-19 COVID-19 NNP cord-277555-tsd6npma 8 13 have have VBP cord-277555-tsd6npma 8 14 led lead VBN cord-277555-tsd6npma 8 15 to to IN cord-277555-tsd6npma 8 16 unprecedented unprecedented JJ cord-277555-tsd6npma 8 17 apprehension apprehension NN cord-277555-tsd6npma 8 18 worldwide worldwide RB cord-277555-tsd6npma 8 19 . . . cord-277555-tsd6npma 9 1 This this DT cord-277555-tsd6npma 9 2 has have VBZ cord-277555-tsd6npma 9 3 resulted result VBN cord-277555-tsd6npma 9 4 in in IN cord-277555-tsd6npma 9 5 equally equally RB cord-277555-tsd6npma 9 6 unprecedented unprecedented JJ cord-277555-tsd6npma 9 7 preventive preventive JJ cord-277555-tsd6npma 9 8 measures measure NNS cord-277555-tsd6npma 9 9 mandated mandate VBN cord-277555-tsd6npma 9 10 by by IN cord-277555-tsd6npma 9 11 national national JJ cord-277555-tsd6npma 9 12 governments government NNS cord-277555-tsd6npma 9 13 as as RB cord-277555-tsd6npma 9 14 well well RB cord-277555-tsd6npma 9 15 as as IN cord-277555-tsd6npma 9 16 to to IN cord-277555-tsd6npma 9 17 an an DT cord-277555-tsd6npma 9 18 explosion explosion NN cord-277555-tsd6npma 9 19 of of IN cord-277555-tsd6npma 9 20 scientific scientific JJ cord-277555-tsd6npma 9 21 activity activity NN cord-277555-tsd6npma 9 22 in in IN cord-277555-tsd6npma 9 23 the the DT cord-277555-tsd6npma 9 24 search search NN cord-277555-tsd6npma 9 25 for for IN cord-277555-tsd6npma 9 26 , , , cord-277555-tsd6npma 9 27 among among IN cord-277555-tsd6npma 9 28 many many JJ cord-277555-tsd6npma 9 29 aspects aspect NNS cord-277555-tsd6npma 9 30 of of IN cord-277555-tsd6npma 9 31 the the DT cord-277555-tsd6npma 9 32 disease disease NN cord-277555-tsd6npma 9 33 , , , cord-277555-tsd6npma 9 34 preventive preventive JJ cord-277555-tsd6npma 9 35 therapy therapy NN cord-277555-tsd6npma 9 36 . . . cord-277555-tsd6npma 10 1 Central central JJ cord-277555-tsd6npma 10 2 to to IN cord-277555-tsd6npma 10 3 this this DT cord-277555-tsd6npma 10 4 search search NN cord-277555-tsd6npma 10 5 for for IN cord-277555-tsd6npma 10 6 preventive preventive JJ cord-277555-tsd6npma 10 7 therapy therapy NN cord-277555-tsd6npma 10 8 is be VBZ cord-277555-tsd6npma 10 9 the the DT cord-277555-tsd6npma 10 10 repurposing repurposing NN cord-277555-tsd6npma 10 11 of of IN cord-277555-tsd6npma 10 12 chloroquine chloroquine NN cord-277555-tsd6npma 10 13 ( ( -LRB- cord-277555-tsd6npma 10 14 CQ CQ NNP cord-277555-tsd6npma 10 15 ) ) -RRB- cord-277555-tsd6npma 10 16 and and CC cord-277555-tsd6npma 10 17 hydroxychloroquine hydroxychloroquine NNP cord-277555-tsd6npma 10 18 ( ( -LRB- cord-277555-tsd6npma 10 19 HCQ HCQ NNP cord-277555-tsd6npma 10 20 ) ) -RRB- cord-277555-tsd6npma 10 21 , , , cord-277555-tsd6npma 10 22 a a DT cord-277555-tsd6npma 10 23 traditional traditional JJ cord-277555-tsd6npma 10 24 antimalarial antimalarial JJ cord-277555-tsd6npma 10 25 drug drug NN cord-277555-tsd6npma 10 26 ( ( -LRB- cord-277555-tsd6npma 10 27 CQ CQ NNP cord-277555-tsd6npma 10 28 ) ) -RRB- cord-277555-tsd6npma 10 29 and and CC cord-277555-tsd6npma 10 30 a a DT cord-277555-tsd6npma 10 31 drug drug NN cord-277555-tsd6npma 10 32 ( ( -LRB- cord-277555-tsd6npma 10 33 HCQ HCQ NNP cord-277555-tsd6npma 10 34 ) ) -RRB- cord-277555-tsd6npma 10 35 also also RB cord-277555-tsd6npma 10 36 used use VBN cord-277555-tsd6npma 10 37 in in IN cord-277555-tsd6npma 10 38 the the DT cord-277555-tsd6npma 10 39 treatment treatment NN cord-277555-tsd6npma 10 40 of of IN cord-277555-tsd6npma 10 41 systemic systemic JJ cord-277555-tsd6npma 10 42 lupus lupus NN cord-277555-tsd6npma 10 43 erythematosus erythematosus NN cord-277555-tsd6npma 10 44 ( ( -LRB- cord-277555-tsd6npma 10 45 SLE SLE NNP cord-277555-tsd6npma 10 46 ) ) -RRB- cord-277555-tsd6npma 10 47 and and CC cord-277555-tsd6npma 10 48 rheumatoid rheumatoid NN cord-277555-tsd6npma 10 49 arthritis arthritis NN cord-277555-tsd6npma 10 50 ( ( -LRB- cord-277555-tsd6npma 10 51 RA RA NNP cord-277555-tsd6npma 10 52 ) ) -RRB- cord-277555-tsd6npma 10 53 . . . cord-277555-tsd6npma 11 1 These these DT cord-277555-tsd6npma 11 2 drugs drug NNS cord-277555-tsd6npma 11 3 have have VBP cord-277555-tsd6npma 11 4 surfaced surface VBN cord-277555-tsd6npma 11 5 as as IN cord-277555-tsd6npma 11 6 a a DT cord-277555-tsd6npma 11 7 potential potential JJ cord-277555-tsd6npma 11 8 effective effective JJ cord-277555-tsd6npma 11 9 treatment treatment NN cord-277555-tsd6npma 11 10 option option NN cord-277555-tsd6npma 11 11 based base VBN cord-277555-tsd6npma 11 12 on on IN cord-277555-tsd6npma 11 13 reasonable reasonable JJ cord-277555-tsd6npma 11 14 experimental experimental JJ cord-277555-tsd6npma 11 15 data datum NNS cord-277555-tsd6npma 11 16 but but CC cord-277555-tsd6npma 11 17 poorly poorly RB cord-277555-tsd6npma 11 18 conducted conduct VBN cord-277555-tsd6npma 11 19 ( ( -LRB- cord-277555-tsd6npma 11 20 first first JJ cord-277555-tsd6npma 11 21 ) ) -RRB- cord-277555-tsd6npma 11 22 clinical clinical JJ cord-277555-tsd6npma 11 23 trials trial NNS cord-277555-tsd6npma 11 24 . . . cord-277555-tsd6npma 12 1 Despite despite IN cord-277555-tsd6npma 12 2 an an DT cord-277555-tsd6npma 12 3 unconfirmed unconfirmed JJ cord-277555-tsd6npma 12 4 efficacy efficacy NN cord-277555-tsd6npma 12 5 and and CC cord-277555-tsd6npma 12 6 potential potential JJ cord-277555-tsd6npma 12 7 serious serious JJ cord-277555-tsd6npma 12 8 side side NN cord-277555-tsd6npma 12 9 - - HYPH cord-277555-tsd6npma 12 10 effects effect NNS cord-277555-tsd6npma 12 11 the the DT cord-277555-tsd6npma 12 12 presidents president NNS cord-277555-tsd6npma 12 13 of of IN cord-277555-tsd6npma 12 14 France France NNP cord-277555-tsd6npma 12 15 , , , cord-277555-tsd6npma 12 16 Brazil Brazil NNP cord-277555-tsd6npma 12 17 and and CC cord-277555-tsd6npma 12 18 the the DT cord-277555-tsd6npma 12 19 United United NNP cord-277555-tsd6npma 12 20 States States NNP cord-277555-tsd6npma 12 21 subsequently subsequently RB cord-277555-tsd6npma 12 22 publicly publicly RB cord-277555-tsd6npma 12 23 promoted promote VBD cord-277555-tsd6npma 12 24 the the DT cord-277555-tsd6npma 12 25 use use NN cord-277555-tsd6npma 12 26 of of IN cord-277555-tsd6npma 12 27 HCQ HCQ NNP cord-277555-tsd6npma 12 28 , , , cord-277555-tsd6npma 12 29 resulting result VBG cord-277555-tsd6npma 12 30 in in IN cord-277555-tsd6npma 12 31 an an DT cord-277555-tsd6npma 12 32 absolute absolute JJ cord-277555-tsd6npma 12 33 run run NN cord-277555-tsd6npma 12 34 on on IN cord-277555-tsd6npma 12 35 HCQ HCQ NNP cord-277555-tsd6npma 12 36 , , , cord-277555-tsd6npma 12 37 a a DT cord-277555-tsd6npma 12 38 shortage shortage NN cord-277555-tsd6npma 12 39 of of IN cord-277555-tsd6npma 12 40 the the DT cord-277555-tsd6npma 12 41 drug drug NN cord-277555-tsd6npma 12 42 for for IN cord-277555-tsd6npma 12 43 patients patient NNS cord-277555-tsd6npma 12 44 with with IN cord-277555-tsd6npma 12 45 traditional traditional JJ cord-277555-tsd6npma 12 46 indications indication NNS cord-277555-tsd6npma 12 47 , , , cord-277555-tsd6npma 12 48 and and CC cord-277555-tsd6npma 12 49 a a DT cord-277555-tsd6npma 12 50 lively lively JJ cord-277555-tsd6npma 12 51 debate debate NN cord-277555-tsd6npma 12 52 in in IN cord-277555-tsd6npma 12 53 the the DT cord-277555-tsd6npma 12 54 respective respective JJ cord-277555-tsd6npma 12 55 countries country NNS cord-277555-tsd6npma 12 56 [ [ -LRB- cord-277555-tsd6npma 12 57 1 1 CD cord-277555-tsd6npma 12 58 , , , cord-277555-tsd6npma 12 59 2 2 CD cord-277555-tsd6npma 12 60 ] ] -RRB- cord-277555-tsd6npma 12 61 . . . cord-277555-tsd6npma 13 1 Cardiac cardiac JJ cord-277555-tsd6npma 13 2 side side NN cord-277555-tsd6npma 13 3 - - HYPH cord-277555-tsd6npma 13 4 effects effect NNS cord-277555-tsd6npma 13 5 of of IN cord-277555-tsd6npma 13 6 these these DT cord-277555-tsd6npma 13 7 drugs drug NNS cord-277555-tsd6npma 13 8 have have VBP cord-277555-tsd6npma 13 9 been be VBN cord-277555-tsd6npma 13 10 known know VBN cord-277555-tsd6npma 13 11 for for IN cord-277555-tsd6npma 13 12 years year NNS cord-277555-tsd6npma 13 13 but but CC cord-277555-tsd6npma 13 14 have have VBP cord-277555-tsd6npma 13 15 been be VBN cord-277555-tsd6npma 13 16 considered consider VBN cord-277555-tsd6npma 13 17 mild mild JJ cord-277555-tsd6npma 13 18 . . . cord-277555-tsd6npma 14 1 One one CD cord-277555-tsd6npma 14 2 potentially potentially RB cord-277555-tsd6npma 14 3 lethal lethal JJ cord-277555-tsd6npma 14 4 side side NN cord-277555-tsd6npma 14 5 - - HYPH cord-277555-tsd6npma 14 6 effect effect NN cord-277555-tsd6npma 14 7 is be VBZ cord-277555-tsd6npma 14 8 QTc qtc JJ cord-277555-tsd6npma 14 9 prolongation prolongation NN cord-277555-tsd6npma 14 10 , , , cord-277555-tsd6npma 14 11 caused cause VBN cord-277555-tsd6npma 14 12 by by IN cord-277555-tsd6npma 14 13 blocking block VBG cord-277555-tsd6npma 14 14 of of IN cord-277555-tsd6npma 14 15 the the DT cord-277555-tsd6npma 14 16 human human JJ cord-277555-tsd6npma 14 17 ether ether NN cord-277555-tsd6npma 14 18 - - HYPH cord-277555-tsd6npma 14 19 a a DT cord-277555-tsd6npma 14 20 - - HYPH cord-277555-tsd6npma 14 21 go go VB cord-277555-tsd6npma 14 22 - - HYPH cord-277555-tsd6npma 14 23 go go VB cord-277555-tsd6npma 14 24 - - HYPH cord-277555-tsd6npma 14 25 related relate VBN cord-277555-tsd6npma 14 26 gene gene NN cord-277555-tsd6npma 14 27 ( ( -LRB- cord-277555-tsd6npma 14 28 hERG herg NN cord-277555-tsd6npma 14 29 ) ) -RRB- cord-277555-tsd6npma 14 30 potassium potassium NN cord-277555-tsd6npma 14 31 channel channel NN cord-277555-tsd6npma 14 32 , , , cord-277555-tsd6npma 14 33 which which WDT cord-277555-tsd6npma 14 34 results result VBZ cord-277555-tsd6npma 14 35 in in IN cord-277555-tsd6npma 14 36 a a DT cord-277555-tsd6npma 14 37 prolonged prolong VBN cord-277555-tsd6npma 14 38 action action NN cord-277555-tsd6npma 14 39 potential potential JJ cord-277555-tsd6npma 14 40 duration duration NN cord-277555-tsd6npma 14 41 [ [ -LRB- cord-277555-tsd6npma 14 42 3 3 CD cord-277555-tsd6npma 14 43 ] ] -RRB- cord-277555-tsd6npma 14 44 . . . cord-277555-tsd6npma 15 1 Due due IN cord-277555-tsd6npma 15 2 to to IN cord-277555-tsd6npma 15 3 the the DT cord-277555-tsd6npma 15 4 potentially potentially RB cord-277555-tsd6npma 15 5 lethal lethal JJ cord-277555-tsd6npma 15 6 nature nature NN cord-277555-tsd6npma 15 7 of of IN cord-277555-tsd6npma 15 8 this this DT cord-277555-tsd6npma 15 9 side side NN cord-277555-tsd6npma 15 10 - - HYPH cord-277555-tsd6npma 15 11 effect effect NN cord-277555-tsd6npma 15 12 , , , cord-277555-tsd6npma 15 13 electrocardiogram electrocardiogram JJ cord-277555-tsd6npma 15 14 ( ( -LRB- cord-277555-tsd6npma 15 15 ECG ECG NNP cord-277555-tsd6npma 15 16 ) ) -RRB- cord-277555-tsd6npma 15 17 monitoring monitoring NN cord-277555-tsd6npma 15 18 in in IN cord-277555-tsd6npma 15 19 patients patient NNS cord-277555-tsd6npma 15 20 treated treat VBN cord-277555-tsd6npma 15 21 with with IN cord-277555-tsd6npma 15 22 these these DT cord-277555-tsd6npma 15 23 drugs drug NNS cord-277555-tsd6npma 15 24 for for IN cord-277555-tsd6npma 15 25 malaria malaria NN cord-277555-tsd6npma 15 26 , , , cord-277555-tsd6npma 15 27 SLE SLE NNP cord-277555-tsd6npma 15 28 or or CC cord-277555-tsd6npma 15 29 RA RA NNP cord-277555-tsd6npma 15 30 has have VBZ cord-277555-tsd6npma 15 31 been be VBN cord-277555-tsd6npma 15 32 proposed propose VBN cord-277555-tsd6npma 15 33 in in IN cord-277555-tsd6npma 15 34 the the DT cord-277555-tsd6npma 15 35 past past NN cord-277555-tsd6npma 15 36 , , , cord-277555-tsd6npma 15 37 but but CC cord-277555-tsd6npma 15 38 is be VBZ cord-277555-tsd6npma 15 39 currently currently RB cord-277555-tsd6npma 15 40 not not RB cord-277555-tsd6npma 15 41 standard standard JJ cord-277555-tsd6npma 15 42 practice practice NN cord-277555-tsd6npma 15 43 [ [ -LRB- cord-277555-tsd6npma 15 44 4 4 CD cord-277555-tsd6npma 15 45 ] ] -RRB- cord-277555-tsd6npma 15 46 . . . cord-277555-tsd6npma 16 1 Actually actually RB cord-277555-tsd6npma 16 2 , , , cord-277555-tsd6npma 16 3 CQ CQ NNP cord-277555-tsd6npma 16 4 is be VBZ cord-277555-tsd6npma 16 5 estimated estimate VBN cord-277555-tsd6npma 16 6 to to TO cord-277555-tsd6npma 16 7 be be VB cord-277555-tsd6npma 16 8 one one CD cord-277555-tsd6npma 16 9 of of IN cord-277555-tsd6npma 16 10 the the DT cord-277555-tsd6npma 16 11 drugs drug NNS cord-277555-tsd6npma 16 12 to to TO cord-277555-tsd6npma 16 13 which which WDT cord-277555-tsd6npma 16 14 human human JJ cord-277555-tsd6npma 16 15 beings being NNS cord-277555-tsd6npma 16 16 are be VBP cord-277555-tsd6npma 16 17 exposed expose VBN cord-277555-tsd6npma 16 18 most most RBS cord-277555-tsd6npma 16 19 [ [ -LRB- cord-277555-tsd6npma 16 20 5 5 CD cord-277555-tsd6npma 16 21 ] ] -RRB- cord-277555-tsd6npma 16 22 . . . cord-277555-tsd6npma 17 1 Yet yet RB cord-277555-tsd6npma 17 2 , , , cord-277555-tsd6npma 17 3 CQ CQ NNP cord-277555-tsd6npma 17 4 and and CC cord-277555-tsd6npma 17 5 HCQ HCQ NNP cord-277555-tsd6npma 17 6 are be VBP cord-277555-tsd6npma 17 7 listed list VBN cord-277555-tsd6npma 17 8 on on IN cord-277555-tsd6npma 17 9 the the DT cord-277555-tsd6npma 17 10 website website NN cord-277555-tsd6npma 17 11 www www NN cord-277555-tsd6npma 17 12 . . . cord-277555-tsd6npma 18 1 crediblemeds.org crediblemeds.org NN cord-277555-tsd6npma 18 2 in in IN cord-277555-tsd6npma 18 3 the the DT cord-277555-tsd6npma 18 4 category category NN cord-277555-tsd6npma 18 5 ' ' '' cord-277555-tsd6npma 18 6 known know VBN cord-277555-tsd6npma 18 7 risk risk NN cord-277555-tsd6npma 18 8 of of IN cord-277555-tsd6npma 18 9 causing cause VBG cord-277555-tsd6npma 18 10 torsades torsade NNS cord-277555-tsd6npma 18 11 de de FW cord-277555-tsd6npma 18 12 pointes pointes FW cord-277555-tsd6npma 18 13 ' ' '' cord-277555-tsd6npma 18 14 . . . cord-277555-tsd6npma 19 1 However however RB cord-277555-tsd6npma 19 2 , , , cord-277555-tsd6npma 19 3 these these DT cord-277555-tsd6npma 19 4 cases case NNS cord-277555-tsd6npma 19 5 are be VBP cord-277555-tsd6npma 19 6 rare rare JJ cord-277555-tsd6npma 19 7 and and CC cord-277555-tsd6npma 19 8 mostly mostly RB cord-277555-tsd6npma 19 9 associated associate VBN cord-277555-tsd6npma 19 10 with with IN cord-277555-tsd6npma 19 11 an an DT cord-277555-tsd6npma 19 12 ( ( -LRB- cord-277555-tsd6npma 19 13 intentional intentional JJ cord-277555-tsd6npma 19 14 ) ) -RRB- cord-277555-tsd6npma 19 15 overdose overdose NN cord-277555-tsd6npma 19 16 or or CC cord-277555-tsd6npma 19 17 in in IN cord-277555-tsd6npma 19 18 combination combination NN cord-277555-tsd6npma 19 19 with with IN cord-277555-tsd6npma 19 20 other other JJ cord-277555-tsd6npma 19 21 QTc qtc NN cord-277555-tsd6npma 19 22 - - HYPH cord-277555-tsd6npma 19 23 prolonging prolong VBG cord-277555-tsd6npma 19 24 factors factor NNS cord-277555-tsd6npma 19 25 ( ( -LRB- cord-277555-tsd6npma 19 26 e.g. e.g. IN cord-277555-tsd6npma 19 27 other other JJ cord-277555-tsd6npma 19 28 drugs drug NNS cord-277555-tsd6npma 19 29 , , , cord-277555-tsd6npma 19 30 hypokalaemia hypokalaemia NN cord-277555-tsd6npma 19 31 ) ) -RRB- cord-277555-tsd6npma 19 32 and and CC cord-277555-tsd6npma 19 33 , , , cord-277555-tsd6npma 19 34 therefore therefore RB cord-277555-tsd6npma 19 35 , , , cord-277555-tsd6npma 19 36 CQ CQ NNP cord-277555-tsd6npma 19 37 and and CC cord-277555-tsd6npma 19 38 HCQ HCQ NNP cord-277555-tsd6npma 19 39 are be VBP cord-277555-tsd6npma 19 40 generally generally RB cord-277555-tsd6npma 19 41 considered consider VBN cord-277555-tsd6npma 19 42 safe safe JJ cord-277555-tsd6npma 19 43 with with IN cord-277555-tsd6npma 19 44 only only RB cord-277555-tsd6npma 19 45 relatively relatively RB cord-277555-tsd6npma 19 46 minor minor JJ cord-277555-tsd6npma 19 47 QTc qtc NN cord-277555-tsd6npma 19 48 prolongation prolongation NN cord-277555-tsd6npma 19 49 [ [ -LRB- cord-277555-tsd6npma 19 50 5 5 CD cord-277555-tsd6npma 19 51 , , , cord-277555-tsd6npma 19 52 6 6 CD cord-277555-tsd6npma 19 53 ] ] -RRB- cord-277555-tsd6npma 19 54 . . . cord-277555-tsd6npma 20 1 Yet yet RB cord-277555-tsd6npma 20 2 , , , cord-277555-tsd6npma 20 3 a a DT cord-277555-tsd6npma 20 4 recent recent JJ cord-277555-tsd6npma 20 5 survey survey NN cord-277555-tsd6npma 20 6 of of IN cord-277555-tsd6npma 20 7 new new JJ cord-277555-tsd6npma 20 8 user user NN cord-277555-tsd6npma 20 9 cohort cohort NN cord-277555-tsd6npma 20 10 studies study NNS cord-277555-tsd6npma 20 11 ( ( -LRB- cord-277555-tsd6npma 20 12 2000 2000 CD cord-277555-tsd6npma 20 13 - - SYM cord-277555-tsd6npma 20 14 2020 2020 CD cord-277555-tsd6npma 20 15 ) ) -RRB- cord-277555-tsd6npma 20 16 in in IN cord-277555-tsd6npma 20 17 almost almost RB cord-277555-tsd6npma 20 18 a a DT cord-277555-tsd6npma 20 19 million million CD cord-277555-tsd6npma 20 20 HCQ HCQ NNP cord-277555-tsd6npma 20 21 users user NNS cord-277555-tsd6npma 20 22 revealed reveal VBD cord-277555-tsd6npma 20 23 slight slight JJ cord-277555-tsd6npma 20 24 excess excess JJ cord-277555-tsd6npma 20 25 cardiovascular cardiovascular JJ cord-277555-tsd6npma 20 26 mortality mortality NN cord-277555-tsd6npma 20 27 most most RBS cord-277555-tsd6npma 20 28 likely likely JJ cord-277555-tsd6npma 20 29 due due JJ cord-277555-tsd6npma 20 30 to to IN cord-277555-tsd6npma 20 31 sudden sudden JJ cord-277555-tsd6npma 20 32 death death NN cord-277555-tsd6npma 20 33 [ [ -LRB- cord-277555-tsd6npma 20 34 7 7 CD cord-277555-tsd6npma 20 35 ] ] -RRB- cord-277555-tsd6npma 20 36 . . . cord-277555-tsd6npma 21 1 Although although IN cord-277555-tsd6npma 21 2 initial initial JJ cord-277555-tsd6npma 21 3 reports report NNS cord-277555-tsd6npma 21 4 , , , cord-277555-tsd6npma 21 5 on on IN cord-277555-tsd6npma 21 6 studies study NNS cord-277555-tsd6npma 21 7 with with IN cord-277555-tsd6npma 21 8 serious serious JJ cord-277555-tsd6npma 21 9 methodological methodological JJ cord-277555-tsd6npma 21 10 flaws flaw NNS cord-277555-tsd6npma 21 11 and and CC cord-277555-tsd6npma 21 12 small small JJ cord-277555-tsd6npma 21 13 sample sample NN cord-277555-tsd6npma 21 14 sizes size NNS cord-277555-tsd6npma 21 15 , , , cord-277555-tsd6npma 21 16 seemed seem VBD cord-277555-tsd6npma 21 17 to to TO cord-277555-tsd6npma 21 18 show show VB cord-277555-tsd6npma 21 19 a a DT cord-277555-tsd6npma 21 20 beneficial beneficial JJ cord-277555-tsd6npma 21 21 effect effect NN cord-277555-tsd6npma 21 22 on on IN cord-277555-tsd6npma 21 23 the the DT cord-277555-tsd6npma 21 24 disease disease NN cord-277555-tsd6npma 21 25 course course NN cord-277555-tsd6npma 21 26 [ [ -LRB- cord-277555-tsd6npma 21 27 8 8 CD cord-277555-tsd6npma 21 28 ] ] -RRB- cord-277555-tsd6npma 21 29 [ [ -LRB- cord-277555-tsd6npma 21 30 9 9 CD cord-277555-tsd6npma 21 31 ] ] -RRB- cord-277555-tsd6npma 21 32 [ [ -LRB- cord-277555-tsd6npma 21 33 10 10 CD cord-277555-tsd6npma 21 34 ] ] -RRB- cord-277555-tsd6npma 21 35 , , , cord-277555-tsd6npma 21 36 evidence evidence NN cord-277555-tsd6npma 21 37 is be VBZ cord-277555-tsd6npma 21 38 accumulating accumulate VBG cord-277555-tsd6npma 21 39 that that IN cord-277555-tsd6npma 21 40 in in IN cord-277555-tsd6npma 21 41 hospitalised hospitalise VBN cord-277555-tsd6npma 21 42 patients patient NNS cord-277555-tsd6npma 21 43 HCQ HCQ NNP cord-277555-tsd6npma 21 44 is be VBZ cord-277555-tsd6npma 21 45 not not RB cord-277555-tsd6npma 21 46 effective effective JJ cord-277555-tsd6npma 21 47 in in IN cord-277555-tsd6npma 21 48 reducing reduce VBG cord-277555-tsd6npma 21 49 mortality mortality NN cord-277555-tsd6npma 21 50 [ [ -LRB- cord-277555-tsd6npma 21 51 11 11 CD cord-277555-tsd6npma 21 52 , , , cord-277555-tsd6npma 21 53 12 12 CD cord-277555-tsd6npma 21 54 ] ] -RRB- cord-277555-tsd6npma 21 55 or or CC cord-277555-tsd6npma 21 56 faster fast JJR cord-277555-tsd6npma 21 57 virus virus NN cord-277555-tsd6npma 21 58 elimination elimination NN cord-277555-tsd6npma 21 59 [ [ -LRB- cord-277555-tsd6npma 21 60 13 13 CD cord-277555-tsd6npma 21 61 ] ] -RRB- cord-277555-tsd6npma 21 62 . . . cord-277555-tsd6npma 22 1 In in IN cord-277555-tsd6npma 22 2 fact fact NN cord-277555-tsd6npma 22 3 , , , cord-277555-tsd6npma 22 4 one one CD cord-277555-tsd6npma 22 5 retrospective retrospective JJ cord-277555-tsd6npma 22 6 study study NN cord-277555-tsd6npma 22 7 comprising comprise VBG cord-277555-tsd6npma 22 8 368 368 CD cord-277555-tsd6npma 22 9 patients patient NNS cord-277555-tsd6npma 22 10 found find VBD cord-277555-tsd6npma 22 11 an an DT cord-277555-tsd6npma 22 12 increased increase VBN cord-277555-tsd6npma 22 13 risk risk NN cord-277555-tsd6npma 22 14 of of IN cord-277555-tsd6npma 22 15 mortality mortality NN cord-277555-tsd6npma 22 16 for for IN cord-277555-tsd6npma 22 17 HCQ HCQ NNP cord-277555-tsd6npma 22 18 , , , cord-277555-tsd6npma 22 19 although although IN cord-277555-tsd6npma 22 20 this this DT cord-277555-tsd6npma 22 21 could could MD cord-277555-tsd6npma 22 22 be be VB cord-277555-tsd6npma 22 23 the the DT cord-277555-tsd6npma 22 24 result result NN cord-277555-tsd6npma 22 25 of of IN cord-277555-tsd6npma 22 26 baseline baseline JJ cord-277555-tsd6npma 22 27 dissimilarities dissimilarity NNS cord-277555-tsd6npma 22 28 between between IN cord-277555-tsd6npma 22 29 the the DT cord-277555-tsd6npma 22 30 intervention intervention NN cord-277555-tsd6npma 22 31 and and CC cord-277555-tsd6npma 22 32 the the DT cord-277555-tsd6npma 22 33 control control NN cord-277555-tsd6npma 22 34 group group NN cord-277555-tsd6npma 22 35 [ [ -LRB- cord-277555-tsd6npma 22 36 12 12 CD cord-277555-tsd6npma 22 37 ] ] -RRB- cord-277555-tsd6npma 22 38 . . . cord-277555-tsd6npma 23 1 This this DT cord-277555-tsd6npma 23 2 negative negative JJ cord-277555-tsd6npma 23 3 effect effect NN cord-277555-tsd6npma 23 4 does do VBZ cord-277555-tsd6npma 23 5 not not RB cord-277555-tsd6npma 23 6 necessarily necessarily RB cord-277555-tsd6npma 23 7 mean mean VB cord-277555-tsd6npma 23 8 that that IN cord-277555-tsd6npma 23 9 CQ CQ NNP cord-277555-tsd6npma 23 10 or or CC cord-277555-tsd6npma 23 11 HCQ HCQ NNP cord-277555-tsd6npma 23 12 are be VBP cord-277555-tsd6npma 23 13 useless useless JJ cord-277555-tsd6npma 23 14 in in IN cord-277555-tsd6npma 23 15 the the DT cord-277555-tsd6npma 23 16 setting setting NN cord-277555-tsd6npma 23 17 of of IN cord-277555-tsd6npma 23 18 a a DT cord-277555-tsd6npma 23 19 SARS SARS NNP cord-277555-tsd6npma 23 20 - - HYPH cord-277555-tsd6npma 23 21 CoV-2 CoV-2 NNP cord-277555-tsd6npma 23 22 infection infection NN cord-277555-tsd6npma 23 23 . . . cord-277555-tsd6npma 24 1 It -PRON- PRP cord-277555-tsd6npma 24 2 is be VBZ cord-277555-tsd6npma 24 3 quite quite RB cord-277555-tsd6npma 24 4 conceivable conceivable JJ cord-277555-tsd6npma 24 5 , , , cord-277555-tsd6npma 24 6 based base VBN cord-277555-tsd6npma 24 7 on on IN cord-277555-tsd6npma 24 8 their -PRON- PRP$ cord-277555-tsd6npma 24 9 demonstrated demonstrate VBN cord-277555-tsd6npma 24 10 in in IN cord-277555-tsd6npma 24 11 vitro vitro FW cord-277555-tsd6npma 24 12 efficacy efficacy NN cord-277555-tsd6npma 24 13 , , , cord-277555-tsd6npma 24 14 that that DT cord-277555-tsd6npma 24 15 treatment treatment NN cord-277555-tsd6npma 24 16 in in IN cord-277555-tsd6npma 24 17 earlier early JJR cord-277555-tsd6npma 24 18 stages stage NNS cord-277555-tsd6npma 24 19 of of IN cord-277555-tsd6npma 24 20 infection infection NN cord-277555-tsd6npma 24 21 might may MD cord-277555-tsd6npma 24 22 be be VB cord-277555-tsd6npma 24 23 beneficial beneficial JJ cord-277555-tsd6npma 24 24 . . . cord-277555-tsd6npma 25 1 This this DT cord-277555-tsd6npma 25 2 reasoning reasoning NN cord-277555-tsd6npma 25 3 underlies underlie VBZ cord-277555-tsd6npma 25 4 the the DT cord-277555-tsd6npma 25 5 many many JJ cord-277555-tsd6npma 25 6 randomised randomised JJ cord-277555-tsd6npma 25 7 trials trial NNS cord-277555-tsd6npma 25 8 that that WDT cord-277555-tsd6npma 25 9 have have VBP cord-277555-tsd6npma 25 10 been be VBN cord-277555-tsd6npma 25 11 proposed propose VBN cord-277555-tsd6npma 25 12 and and CC cord-277555-tsd6npma 25 13 initiated initiate VBN cord-277555-tsd6npma 25 14 , , , cord-277555-tsd6npma 25 15 also also RB cord-277555-tsd6npma 25 16 focusing focus VBG cord-277555-tsd6npma 25 17 on on IN cord-277555-tsd6npma 25 18 prevention prevention NN cord-277555-tsd6npma 25 19 of of IN cord-277555-tsd6npma 25 20 infection infection NN cord-277555-tsd6npma 25 21 ( ( -LRB- cord-277555-tsd6npma 25 22 i.e. i.e. FW cord-277555-tsd6npma 25 23 pre pre JJ cord-277555-tsd6npma 25 24 - - JJ cord-277555-tsd6npma 25 25 exposure exposure JJ cord-277555-tsd6npma 25 26 ) ) -RRB- cord-277555-tsd6npma 25 27 , , , cord-277555-tsd6npma 25 28 mainly mainly RB cord-277555-tsd6npma 25 29 in in IN cord-277555-tsd6npma 25 30 healthcare healthcare NN cord-277555-tsd6npma 25 31 workers worker NNS cord-277555-tsd6npma 25 32 , , , cord-277555-tsd6npma 25 33 and and CC cord-277555-tsd6npma 25 34 post post JJ cord-277555-tsd6npma 25 35 - - NN cord-277555-tsd6npma 25 36 exposure exposure NN cord-277555-tsd6npma 25 37 shortly shortly RB cord-277555-tsd6npma 25 38 after after IN cord-277555-tsd6npma 25 39 the the DT cord-277555-tsd6npma 25 40 onset onset NN cord-277555-tsd6npma 25 41 of of IN cord-277555-tsd6npma 25 42 disease disease NN cord-277555-tsd6npma 25 43 symptoms symptom NNS cord-277555-tsd6npma 25 44 [ [ -LRB- cord-277555-tsd6npma 25 45 14 14 CD cord-277555-tsd6npma 25 46 ] ] -RRB- cord-277555-tsd6npma 25 47 . . . cord-277555-tsd6npma 26 1 In in IN cord-277555-tsd6npma 26 2 two two CD cord-277555-tsd6npma 26 3 studies study NNS cord-277555-tsd6npma 26 4 in in IN cord-277555-tsd6npma 26 5 this this DT cord-277555-tsd6npma 26 6 issue issue NN cord-277555-tsd6npma 26 7 of of IN cord-277555-tsd6npma 26 8 this this DT cord-277555-tsd6npma 26 9 journal journal NN cord-277555-tsd6npma 26 10 , , , cord-277555-tsd6npma 26 11 the the DT cord-277555-tsd6npma 26 12 effect effect NN cord-277555-tsd6npma 26 13 of of IN cord-277555-tsd6npma 26 14 CQ CQ NNP cord-277555-tsd6npma 26 15 was be VBD cord-277555-tsd6npma 26 16 studied study VBN cord-277555-tsd6npma 26 17 in in IN cord-277555-tsd6npma 26 18 hospitalised hospitalise VBN cord-277555-tsd6npma 26 19 patients patient NNS cord-277555-tsd6npma 26 20 with with IN cord-277555-tsd6npma 26 21 emphasis emphasis NN cord-277555-tsd6npma 26 22 on on IN cord-277555-tsd6npma 26 23 the the DT cord-277555-tsd6npma 26 24 main main JJ cord-277555-tsd6npma 26 25 side side NN cord-277555-tsd6npma 26 26 - - HYPH cord-277555-tsd6npma 26 27 effect effect NN cord-277555-tsd6npma 26 28 of of IN cord-277555-tsd6npma 26 29 the the DT cord-277555-tsd6npma 26 30 drug drug NN cord-277555-tsd6npma 26 31 , , , cord-277555-tsd6npma 26 32 i.e. i.e. FW cord-277555-tsd6npma 26 33 pro pro FW cord-277555-tsd6npma 26 34 - - JJ cord-277555-tsd6npma 26 35 The the DT cord-277555-tsd6npma 26 36 ' ' `` cord-277555-tsd6npma 26 37 president president NN cord-277555-tsd6npma 26 38 's 's POS cord-277555-tsd6npma 26 39 drug drug NN cord-277555-tsd6npma 26 40 ' ' POS cord-277555-tsd6npma 26 41 longation longation NN cord-277555-tsd6npma 26 42 of of IN cord-277555-tsd6npma 26 43 the the DT cord-277555-tsd6npma 26 44 QTc QTc NNP cord-277555-tsd6npma 26 45 interval interval NN cord-277555-tsd6npma 26 46 . . . cord-277555-tsd6npma 27 1 Outcome outcome NN cord-277555-tsd6npma 27 2 data datum NNS cord-277555-tsd6npma 27 3 were be VBD cord-277555-tsd6npma 27 4 not not RB cord-277555-tsd6npma 27 5 included include VBN cord-277555-tsd6npma 27 6 in in IN cord-277555-tsd6npma 27 7 these these DT cord-277555-tsd6npma 27 8 reports report NNS cord-277555-tsd6npma 27 9 . . . cord-277555-tsd6npma 28 1 In in IN cord-277555-tsd6npma 28 2 the the DT cord-277555-tsd6npma 28 3 study study NN cord-277555-tsd6npma 28 4 by by IN cord-277555-tsd6npma 28 5 van van NNP cord-277555-tsd6npma 28 6 den den NNP cord-277555-tsd6npma 28 7 Broek Broek NNP cord-277555-tsd6npma 28 8 et et NNP cord-277555-tsd6npma 28 9 al al NNP cord-277555-tsd6npma 28 10 . . . cord-277555-tsd6npma 29 1 , , , cord-277555-tsd6npma 29 2 95 95 CD cord-277555-tsd6npma 29 3 patients patient NNS cord-277555-tsd6npma 29 4 were be VBD cord-277555-tsd6npma 29 5 treated treat VBN cord-277555-tsd6npma 29 6 with with IN cord-277555-tsd6npma 29 7 CQ CQ NNP cord-277555-tsd6npma 29 8 ( ( -LRB- cord-277555-tsd6npma 29 9 loading loading NN cord-277555-tsd6npma 29 10 dose dose NN cord-277555-tsd6npma 29 11 600 600 CD cord-277555-tsd6npma 29 12 mg mg NNP cord-277555-tsd6npma 29 13 , , , cord-277555-tsd6npma 29 14 followed follow VBN cord-277555-tsd6npma 29 15 by by IN cord-277555-tsd6npma 29 16 2 2 CD cord-277555-tsd6npma 29 17 × × NN cord-277555-tsd6npma 29 18 300 300 CD cord-277555-tsd6npma 29 19 mg mg NN cord-277555-tsd6npma 29 20 for for IN cord-277555-tsd6npma 29 21 4 4 CD cord-277555-tsd6npma 29 22 days day NNS cord-277555-tsd6npma 29 23 ; ; : cord-277555-tsd6npma 29 24 22 22 CD cord-277555-tsd6npma 29 25 % % NN cord-277555-tsd6npma 29 26 of of IN cord-277555-tsd6npma 29 27 patients patient NNS cord-277555-tsd6npma 29 28 in in IN cord-277555-tsd6npma 29 29 the the DT cord-277555-tsd6npma 29 30 intensive intensive JJ cord-277555-tsd6npma 29 31 care care NN cord-277555-tsd6npma 29 32 unit unit NN cord-277555-tsd6npma 29 33 ) ) -RRB- cord-277555-tsd6npma 29 34 , , , cord-277555-tsd6npma 29 35 which which WDT cord-277555-tsd6npma 29 36 resulted result VBD cord-277555-tsd6npma 29 37 in in IN cord-277555-tsd6npma 29 38 a a DT cord-277555-tsd6npma 29 39 mean mean NN cord-277555-tsd6npma 29 40 QTc qtc NN cord-277555-tsd6npma 29 41 prolongation prolongation NN cord-277555-tsd6npma 29 42 of of IN cord-277555-tsd6npma 29 43 35 35 CD cord-277555-tsd6npma 29 44 ms m NNS cord-277555-tsd6npma 29 45 ( ( -LRB- cord-277555-tsd6npma 29 46 95 95 CD cord-277555-tsd6npma 29 47 % % NN cord-277555-tsd6npma 29 48 confidence confidence NN cord-277555-tsd6npma 29 49 interval interval NN cord-277555-tsd6npma 29 50 28 28 CD cord-277555-tsd6npma 29 51 - - SYM cord-277555-tsd6npma 29 52 43 43 CD cord-277555-tsd6npma 29 53 ms m NNS cord-277555-tsd6npma 29 54 ) ) -RRB- cord-277555-tsd6npma 29 55 [ [ -LRB- cord-277555-tsd6npma 29 56 15 15 CD cord-277555-tsd6npma 29 57 ] ] -RRB- cord-277555-tsd6npma 29 58 . . . cord-277555-tsd6npma 30 1 In in IN cord-277555-tsd6npma 30 2 22 22 CD cord-277555-tsd6npma 30 3 patients patient NNS cord-277555-tsd6npma 30 4 ( ( -LRB- cord-277555-tsd6npma 30 5 23 23 CD cord-277555-tsd6npma 30 6 % % NN cord-277555-tsd6npma 30 7 ) ) -RRB- cord-277555-tsd6npma 30 8 the the DT cord-277555-tsd6npma 30 9 QTc QTc NNP cord-277555-tsd6npma 30 10 interval interval NN cord-277555-tsd6npma 30 11 exceeded exceed VBD cord-277555-tsd6npma 30 12 500 500 CD cord-277555-tsd6npma 30 13 ms ms NNP cord-277555-tsd6npma 30 14 , , , cord-277555-tsd6npma 30 15 which which WDT cord-277555-tsd6npma 30 16 is be VBZ cord-277555-tsd6npma 30 17 generally generally RB cord-277555-tsd6npma 30 18 regarded regard VBN cord-277555-tsd6npma 30 19 as as IN cord-277555-tsd6npma 30 20 the the DT cord-277555-tsd6npma 30 21 value value NN cord-277555-tsd6npma 30 22 at at IN cord-277555-tsd6npma 30 23 which which WDT cord-277555-tsd6npma 30 24 to to TO cord-277555-tsd6npma 30 25 stop stop VB cord-277555-tsd6npma 30 26 all all DT cord-277555-tsd6npma 30 27 QT qt NN cord-277555-tsd6npma 30 28 - - HYPH cord-277555-tsd6npma 30 29 prolonging prolong VBG cord-277555-tsd6npma 30 30 medication medication NN cord-277555-tsd6npma 30 31 . . . cord-277555-tsd6npma 31 1 Interestingly interestingly RB cord-277555-tsd6npma 31 2 , , , cord-277555-tsd6npma 31 3 in in IN cord-277555-tsd6npma 31 4 addition addition NN cord-277555-tsd6npma 31 5 to to IN cord-277555-tsd6npma 31 6 QTc qtc VB cord-277555-tsd6npma 31 7 prolongation prolongation NN cord-277555-tsd6npma 31 8 , , , cord-277555-tsd6npma 31 9 the the DT cord-277555-tsd6npma 31 10 authors author NNS cord-277555-tsd6npma 31 11 also also RB cord-277555-tsd6npma 31 12 detected detect VBD cord-277555-tsd6npma 31 13 PR PR NNP cord-277555-tsd6npma 31 14 and and CC cord-277555-tsd6npma 31 15 QRS QRS NNP cord-277555-tsd6npma 31 16 prolongation prolongation NN cord-277555-tsd6npma 31 17 , , , cord-277555-tsd6npma 31 18 a a DT cord-277555-tsd6npma 31 19 known know VBN cord-277555-tsd6npma 31 20 effect effect NN cord-277555-tsd6npma 31 21 of of IN cord-277555-tsd6npma 31 22 CQ CQ NNP cord-277555-tsd6npma 31 23 [ [ -LRB- cord-277555-tsd6npma 31 24 5 5 CD cord-277555-tsd6npma 31 25 ] ] -RRB- cord-277555-tsd6npma 31 26 . . . cord-277555-tsd6npma 32 1 This this DT cord-277555-tsd6npma 32 2 indicates indicate VBZ cord-277555-tsd6npma 32 3 a a DT cord-277555-tsd6npma 32 4 decrease decrease NN cord-277555-tsd6npma 32 5 in in IN cord-277555-tsd6npma 32 6 conduction conduction NN cord-277555-tsd6npma 32 7 , , , cord-277555-tsd6npma 32 8 which which WDT cord-277555-tsd6npma 32 9 is be VBZ cord-277555-tsd6npma 32 10 also also RB cord-277555-tsd6npma 32 11 potentially potentially RB cord-277555-tsd6npma 32 12 pro pro JJ cord-277555-tsd6npma 32 13 - - JJ cord-277555-tsd6npma 32 14 arrhythmic arrhythmic JJ cord-277555-tsd6npma 32 15 by by IN cord-277555-tsd6npma 32 16 favouring favour VBG cord-277555-tsd6npma 32 17 re re NN cord-277555-tsd6npma 32 18 - - NN cord-277555-tsd6npma 32 19 entrant entrant JJ cord-277555-tsd6npma 32 20 circuits circuit NNS cord-277555-tsd6npma 32 21 . . . cord-277555-tsd6npma 33 1 In in IN cord-277555-tsd6npma 33 2 the the DT cord-277555-tsd6npma 33 3 study study NN cord-277555-tsd6npma 33 4 by by IN cord-277555-tsd6npma 33 5 Sinkeler Sinkeler NNP cord-277555-tsd6npma 33 6 et et NNP cord-277555-tsd6npma 33 7 al al NNP cord-277555-tsd6npma 33 8 . . . cord-277555-tsd6npma 34 1 397 397 CD cord-277555-tsd6npma 34 2 hospitalised hospitalise VBN cord-277555-tsd6npma 34 3 patients patient NNS cord-277555-tsd6npma 34 4 were be VBD cord-277555-tsd6npma 34 5 treated treat VBN cord-277555-tsd6npma 34 6 with with IN cord-277555-tsd6npma 34 7 CQ CQ NNP cord-277555-tsd6npma 34 8 ( ( -LRB- cord-277555-tsd6npma 34 9 same same JJ cord-277555-tsd6npma 34 10 dosage dosage NN cord-277555-tsd6npma 34 11 regimen regimen NN cord-277555-tsd6npma 34 12 ) ) -RRB- cord-277555-tsd6npma 34 13 [ [ -LRB- cord-277555-tsd6npma 34 14 16 16 CD cord-277555-tsd6npma 34 15 ] ] -RRB- cord-277555-tsd6npma 34 16 . . . cord-277555-tsd6npma 35 1 After after IN cord-277555-tsd6npma 35 2 24 24 CD cord-277555-tsd6npma 35 3 - - SYM cord-277555-tsd6npma 35 4 72 72 CD cord-277555-tsd6npma 35 5 h h NN cord-277555-tsd6npma 35 6 the the DT cord-277555-tsd6npma 35 7 QTc qtc NN cord-277555-tsd6npma 35 8 had have VBD cord-277555-tsd6npma 35 9 increased increase VBN cord-277555-tsd6npma 35 10 by by IN cord-277555-tsd6npma 35 11 20 20 CD cord-277555-tsd6npma 35 12 ms ms NNP cord-277555-tsd6npma 35 13 ( ( -LRB- cord-277555-tsd6npma 35 14 ±39 ±39 NNP cord-277555-tsd6npma 35 15 ms ms NNP cord-277555-tsd6npma 35 16 , , , cord-277555-tsd6npma 35 17 mean mean JJ cord-277555-tsd6npma 35 18 ± ± NNP cord-277555-tsd6npma 35 19 SD SD NNP cord-277555-tsd6npma 35 20 ) ) -RRB- cord-277555-tsd6npma 35 21 ; ; : cord-277555-tsd6npma 35 22 a a DT cord-277555-tsd6npma 35 23 second second JJ cord-277555-tsd6npma 35 24 ECG ECG NNP cord-277555-tsd6npma 35 25 in in IN cord-277555-tsd6npma 35 26 a a DT cord-277555-tsd6npma 35 27 subset subset NN cord-277555-tsd6npma 35 28 of of IN cord-277555-tsd6npma 35 29 patients patient NNS cord-277555-tsd6npma 35 30 revealed reveal VBD cord-277555-tsd6npma 35 31 a a DT cord-277555-tsd6npma 35 32 further further JJ cord-277555-tsd6npma 35 33 increase increase NN cord-277555-tsd6npma 35 34 to to IN cord-277555-tsd6npma 35 35 33 33 CD cord-277555-tsd6npma 35 36 ± ± CD cord-277555-tsd6npma 35 37 53 53 CD cord-277555-tsd6npma 36 1 ms ms NNP cord-277555-tsd6npma 36 2 . . . cord-277555-tsd6npma 37 1 In in IN cord-277555-tsd6npma 37 2 ±16 ±16 NNP cord-277555-tsd6npma 37 3 % % NN cord-277555-tsd6npma 37 4 of of IN cord-277555-tsd6npma 37 5 patients patient NNS cord-277555-tsd6npma 37 6 the the DT cord-277555-tsd6npma 37 7 QTc QTc NNP cord-277555-tsd6npma 37 8 interval interval NN cord-277555-tsd6npma 37 9 exceeded exceed VBD cord-277555-tsd6npma 37 10 500 500 CD cord-277555-tsd6npma 37 11 ms m NNS cord-277555-tsd6npma 37 12 and/or and/or CC cord-277555-tsd6npma 38 1 the the DT cord-277555-tsd6npma 38 2 increase increase NN cord-277555-tsd6npma 38 3 in in IN cord-277555-tsd6npma 38 4 QTc qtc NN cord-277555-tsd6npma 38 5 was be VBD cord-277555-tsd6npma 38 6 more more JJR cord-277555-tsd6npma 38 7 than than IN cord-277555-tsd6npma 38 8 60 60 CD cord-277555-tsd6npma 38 9 ms m NNS cord-277555-tsd6npma 38 10 . . . cord-277555-tsd6npma 39 1 One one CD cord-277555-tsd6npma 39 2 patient patient NN cord-277555-tsd6npma 39 3 developed develop VBD cord-277555-tsd6npma 39 4 a a DT cord-277555-tsd6npma 39 5 non non JJ cord-277555-tsd6npma 39 6 - - JJ cord-277555-tsd6npma 39 7 sustained sustained JJ cord-277555-tsd6npma 39 8 ventricular ventricular JJ cord-277555-tsd6npma 39 9 tachycardia tachycardia NN cord-277555-tsd6npma 39 10 . . . cord-277555-tsd6npma 40 1 Although although IN cord-277555-tsd6npma 40 2 in in IN cord-277555-tsd6npma 40 3 both both DT cord-277555-tsd6npma 40 4 studies study NNS cord-277555-tsd6npma 40 5 serum serum NN cord-277555-tsd6npma 40 6 potassium potassium NN cord-277555-tsd6npma 40 7 levels level NNS cord-277555-tsd6npma 40 8 were be VBD cord-277555-tsd6npma 40 9 measured measure VBN cord-277555-tsd6npma 40 10 and and CC cord-277555-tsd6npma 40 11 the the DT cord-277555-tsd6npma 40 12 use use NN cord-277555-tsd6npma 40 13 of of IN cord-277555-tsd6npma 40 14 additional additional JJ cord-277555-tsd6npma 40 15 QTc qtc NN cord-277555-tsd6npma 40 16 - - HYPH cord-277555-tsd6npma 40 17 prolonging prolong VBG cord-277555-tsd6npma 40 18 drugs drug NNS cord-277555-tsd6npma 40 19 was be VBD cord-277555-tsd6npma 40 20 recorded record VBN cord-277555-tsd6npma 40 21 , , , cord-277555-tsd6npma 40 22 details detail NNS cord-277555-tsd6npma 40 23 are be VBP cord-277555-tsd6npma 40 24 not not RB cord-277555-tsd6npma 40 25 given give VBN cord-277555-tsd6npma 40 26 in in IN cord-277555-tsd6npma 40 27 relation relation NN cord-277555-tsd6npma 40 28 to to IN cord-277555-tsd6npma 40 29 the the DT cord-277555-tsd6npma 40 30 QTc QTc NNP cord-277555-tsd6npma 40 31 prolongation prolongation NN cord-277555-tsd6npma 40 32 . . . cord-277555-tsd6npma 41 1 Also also RB cord-277555-tsd6npma 41 2 , , , cord-277555-tsd6npma 41 3 in in IN cord-277555-tsd6npma 41 4 both both DT cord-277555-tsd6npma 41 5 studies study NNS cord-277555-tsd6npma 41 6 the the DT cord-277555-tsd6npma 41 7 computer computer NN cord-277555-tsd6npma 41 8 - - HYPH cord-277555-tsd6npma 41 9 measured measure VBN cord-277555-tsd6npma 41 10 ECG ECG NNP cord-277555-tsd6npma 41 11 overestimated overestimate VBD cord-277555-tsd6npma 41 12 the the DT cord-277555-tsd6npma 41 13 QTc QTc NNP cord-277555-tsd6npma 41 14 interval interval NN cord-277555-tsd6npma 41 15 , , , cord-277555-tsd6npma 41 16 so so CC cord-277555-tsd6npma 41 17 in in IN cord-277555-tsd6npma 41 18 patients patient NNS cord-277555-tsd6npma 41 19 where where WRB cord-277555-tsd6npma 41 20 clinical clinical JJ cord-277555-tsd6npma 41 21 decision decision NN cord-277555-tsd6npma 41 22 - - HYPH cord-277555-tsd6npma 41 23 making making NN cord-277555-tsd6npma 41 24 depends depend VBZ cord-277555-tsd6npma 41 25 on on IN cord-277555-tsd6npma 41 26 the the DT cord-277555-tsd6npma 41 27 QTc QTc NNPS cord-277555-tsd6npma 41 28 interval interval NN cord-277555-tsd6npma 41 29 a a DT cord-277555-tsd6npma 41 30 manual manual JJ cord-277555-tsd6npma 41 31 measurement measurement NN cord-277555-tsd6npma 41 32 is be VBZ cord-277555-tsd6npma 41 33 mandatory mandatory JJ cord-277555-tsd6npma 41 34 . . . cord-277555-tsd6npma 42 1 These these DT cord-277555-tsd6npma 42 2 results result NNS cord-277555-tsd6npma 42 3 are be VBP cord-277555-tsd6npma 42 4 in in IN cord-277555-tsd6npma 42 5 line line NN cord-277555-tsd6npma 42 6 with with IN cord-277555-tsd6npma 42 7 other other JJ cord-277555-tsd6npma 42 8 published publish VBN cord-277555-tsd6npma 42 9 data datum NNS cord-277555-tsd6npma 42 10 summarised summarise VBN cord-277555-tsd6npma 42 11 in in IN cord-277555-tsd6npma 42 12 a a DT cord-277555-tsd6npma 42 13 recent recent JJ cord-277555-tsd6npma 42 14 review review NN cord-277555-tsd6npma 42 15 [ [ -LRB- cord-277555-tsd6npma 42 16 17 17 CD cord-277555-tsd6npma 42 17 ] ] -RRB- cord-277555-tsd6npma 42 18 . . . cord-277555-tsd6npma 43 1 Up up IN cord-277555-tsd6npma 43 2 to to TO cord-277555-tsd6npma 43 3 20 20 CD cord-277555-tsd6npma 43 4 % % NN cord-277555-tsd6npma 43 5 of of IN cord-277555-tsd6npma 43 6 patients patient NNS cord-277555-tsd6npma 43 7 develop develop VBP cord-277555-tsd6npma 43 8 QTc qtc PRP$ cord-277555-tsd6npma 43 9 prolongation prolongation NN cord-277555-tsd6npma 43 10 into into IN cord-277555-tsd6npma 43 11 the the DT cord-277555-tsd6npma 43 12 range range NN cord-277555-tsd6npma 44 1 ≥500 ≥500 . cord-277555-tsd6npma 45 1 ms ms NNP cord-277555-tsd6npma 45 2 with with IN cord-277555-tsd6npma 45 3 CQ CQ NNP cord-277555-tsd6npma 45 4 - - HYPH cord-277555-tsd6npma 45 5 HCQ HCQ NNP cord-277555-tsd6npma 45 6 monotherapy monotherapy NN cord-277555-tsd6npma 45 7 and and CC cord-277555-tsd6npma 45 8 slightly slightly RB cord-277555-tsd6npma 45 9 more more JJR cord-277555-tsd6npma 45 10 when when WRB cord-277555-tsd6npma 45 11 azithromycin azithromycin NNP cord-277555-tsd6npma 45 12 is be VBZ cord-277555-tsd6npma 45 13 added add VBN cord-277555-tsd6npma 45 14 [ [ -LRB- cord-277555-tsd6npma 45 15 17 17 CD cord-277555-tsd6npma 45 16 ] ] -RRB- cord-277555-tsd6npma 45 17 . . . cord-277555-tsd6npma 46 1 However however RB cord-277555-tsd6npma 46 2 , , , cord-277555-tsd6npma 46 3 only only RB cord-277555-tsd6npma 46 4 rarely rarely RB cord-277555-tsd6npma 46 5 does do VBZ cord-277555-tsd6npma 46 6 a a DT cord-277555-tsd6npma 46 7 patient patient NN cord-277555-tsd6npma 46 8 develop develop VB cord-277555-tsd6npma 46 9 torsades torsade NNS cord-277555-tsd6npma 46 10 de de FW cord-277555-tsd6npma 46 11 pointes pointes FW cord-277555-tsd6npma 46 12 ; ; : cord-277555-tsd6npma 46 13 a a DT cord-277555-tsd6npma 46 14 nice nice JJ cord-277555-tsd6npma 46 15 example example NN cord-277555-tsd6npma 46 16 is be VBZ cord-277555-tsd6npma 46 17 described describe VBN cord-277555-tsd6npma 46 18 by by IN cord-277555-tsd6npma 46 19 Szekely Szekely NNP cord-277555-tsd6npma 46 20 et et NNP cord-277555-tsd6npma 46 21 al al NNP cord-277555-tsd6npma 46 22 . . . cord-277555-tsd6npma 47 1 [ [ -LRB- cord-277555-tsd6npma 47 2 18 18 CD cord-277555-tsd6npma 47 3 ] ] -RRB- cord-277555-tsd6npma 47 4 . . . cord-277555-tsd6npma 48 1 Specific specific JJ cord-277555-tsd6npma 48 2 subgroups subgroup NNS cord-277555-tsd6npma 48 3 at at IN cord-277555-tsd6npma 48 4 high high JJ cord-277555-tsd6npma 48 5 risk risk NN cord-277555-tsd6npma 48 6 are be VBP cord-277555-tsd6npma 48 7 recognised recognise VBN cord-277555-tsd6npma 48 8 and and CC cord-277555-tsd6npma 48 9 should should MD cord-277555-tsd6npma 48 10 undergo undergo VB cord-277555-tsd6npma 48 11 extra extra JJ cord-277555-tsd6npma 48 12 - - JJ cord-277555-tsd6npma 48 13 intense intense JJ cord-277555-tsd6npma 48 14 ECG ECG NNP cord-277555-tsd6npma 48 15 monitoring monitor VBG cord-277555-tsd6npma 48 16 [ [ -LRB- cord-277555-tsd6npma 48 17 19 19 CD cord-277555-tsd6npma 48 18 ] ] -RRB- cord-277555-tsd6npma 48 19 . . . cord-277555-tsd6npma 49 1 An an DT cord-277555-tsd6npma 49 2 important important JJ cord-277555-tsd6npma 49 3 finding finding NN cord-277555-tsd6npma 49 4 of of IN cord-277555-tsd6npma 49 5 both both DT cord-277555-tsd6npma 49 6 studies study NNS cord-277555-tsd6npma 49 7 and and CC cord-277555-tsd6npma 49 8 other other JJ cord-277555-tsd6npma 49 9 studies study NNS cord-277555-tsd6npma 49 10 on on IN cord-277555-tsd6npma 49 11 this this DT cord-277555-tsd6npma 49 12 topic topic NN cord-277555-tsd6npma 49 13 is be VBZ cord-277555-tsd6npma 49 14 that that IN cord-277555-tsd6npma 49 15 COVID-19 covid-19 CD cord-277555-tsd6npma 49 16 patients patient NNS cord-277555-tsd6npma 49 17 are be VBP cord-277555-tsd6npma 49 18 apparently apparently RB cord-277555-tsd6npma 49 19 much much RB cord-277555-tsd6npma 49 20 more more RBR cord-277555-tsd6npma 49 21 sensitive sensitive JJ cord-277555-tsd6npma 49 22 to to IN cord-277555-tsd6npma 49 23 CQ CQ NNP cord-277555-tsd6npma 49 24 - - : cord-277555-tsd6npma 49 25 or or CC cord-277555-tsd6npma 49 26 HCQ HCQ NNP cord-277555-tsd6npma 49 27 - - HYPH cord-277555-tsd6npma 49 28 related relate VBN cord-277555-tsd6npma 49 29 QTc qtc NN cord-277555-tsd6npma 49 30 prolongation prolongation NN cord-277555-tsd6npma 49 31 than than IN cord-277555-tsd6npma 49 32 patients patient NNS cord-277555-tsd6npma 49 33 with with IN cord-277555-tsd6npma 49 34 more more JJR cord-277555-tsd6npma 49 35 conventional conventional JJ cord-277555-tsd6npma 49 36 indications indication NNS cord-277555-tsd6npma 49 37 . . . cord-277555-tsd6npma 50 1 This this DT cord-277555-tsd6npma 50 2 is be VBZ cord-277555-tsd6npma 50 3 potentially potentially RB cord-277555-tsd6npma 50 4 explained explain VBN cord-277555-tsd6npma 50 5 by by IN cord-277555-tsd6npma 50 6 a a DT cord-277555-tsd6npma 50 7 number number NN cord-277555-tsd6npma 50 8 of of IN cord-277555-tsd6npma 50 9 factors factor NNS cord-277555-tsd6npma 50 10 which which WDT cord-277555-tsd6npma 50 11 may may MD cord-277555-tsd6npma 50 12 contribute contribute VB cord-277555-tsd6npma 50 13 to to IN cord-277555-tsd6npma 50 14 the the DT cord-277555-tsd6npma 50 15 QT QT NNP cord-277555-tsd6npma 50 16 prolongation prolongation NN cord-277555-tsd6npma 50 17 . . . cord-277555-tsd6npma 51 1 In in IN cord-277555-tsd6npma 51 2 hospitalised hospitalise VBN cord-277555-tsd6npma 51 3 COVID-19 covid-19 CD cord-277555-tsd6npma 51 4 patients patient NNS cord-277555-tsd6npma 51 5 there there EX cord-277555-tsd6npma 51 6 is be VBZ cord-277555-tsd6npma 51 7 an an DT cord-277555-tsd6npma 51 8 exaggerated exaggerated JJ cord-277555-tsd6npma 51 9 immune immune JJ cord-277555-tsd6npma 51 10 response response NN cord-277555-tsd6npma 51 11 , , , cord-277555-tsd6npma 51 12 resulting result VBG cord-277555-tsd6npma 51 13 in in IN cord-277555-tsd6npma 51 14 high high JJ cord-277555-tsd6npma 51 15 levels level NNS cord-277555-tsd6npma 51 16 of of IN cord-277555-tsd6npma 51 17 cytokines cytokine NNS cord-277555-tsd6npma 51 18 , , , cord-277555-tsd6npma 51 19 including include VBG cord-277555-tsd6npma 51 20 interleukin interleukin NN cord-277555-tsd6npma 51 21 6 6 CD cord-277555-tsd6npma 51 22 , , , cord-277555-tsd6npma 51 23 which which WDT cord-277555-tsd6npma 51 24 has have VBZ cord-277555-tsd6npma 51 25 been be VBN cord-277555-tsd6npma 51 26 shown show VBN cord-277555-tsd6npma 51 27 to to TO cord-277555-tsd6npma 51 28 prolong prolong VB cord-277555-tsd6npma 51 29 repolarisation repolarisation NN cord-277555-tsd6npma 51 30 [ [ -LRB- cord-277555-tsd6npma 51 31 20 20 CD cord-277555-tsd6npma 51 32 ] ] -RRB- cord-277555-tsd6npma 51 33 . . . cord-277555-tsd6npma 52 1 Furthermore furthermore RB cord-277555-tsd6npma 52 2 , , , cord-277555-tsd6npma 52 3 hypoxia hypoxia NN cord-277555-tsd6npma 52 4 may may MD cord-277555-tsd6npma 52 5 augment augment VB cord-277555-tsd6npma 52 6 the the DT cord-277555-tsd6npma 52 7 late late JJ cord-277555-tsd6npma 52 8 sodium sodium NN cord-277555-tsd6npma 52 9 inward inward RB cord-277555-tsd6npma 52 10 current current JJ cord-277555-tsd6npma 52 11 , , , cord-277555-tsd6npma 52 12 and and CC cord-277555-tsd6npma 52 13 subsequently subsequently RB cord-277555-tsd6npma 52 14 prolong prolong VB cord-277555-tsd6npma 52 15 the the DT cord-277555-tsd6npma 52 16 action action NN cord-277555-tsd6npma 52 17 potential potential JJ cord-277555-tsd6npma 52 18 duration duration NN cord-277555-tsd6npma 52 19 [ [ -LRB- cord-277555-tsd6npma 52 20 21 21 CD cord-277555-tsd6npma 52 21 ] ] -RRB- cord-277555-tsd6npma 52 22 . . . cord-277555-tsd6npma 53 1 In in IN cord-277555-tsd6npma 53 2 addition addition NN cord-277555-tsd6npma 53 3 , , , cord-277555-tsd6npma 53 4 sick sick JJ cord-277555-tsd6npma 53 5 patients patient NNS cord-277555-tsd6npma 53 6 may may MD cord-277555-tsd6npma 53 7 use use VB cord-277555-tsd6npma 53 8 other other JJ cord-277555-tsd6npma 53 9 QT qt NN cord-277555-tsd6npma 53 10 - - HYPH cord-277555-tsd6npma 53 11 prolonging prolong VBG cord-277555-tsd6npma 53 12 drugs drug NNS cord-277555-tsd6npma 53 13 , , , cord-277555-tsd6npma 53 14 including include VBG cord-277555-tsd6npma 53 15 the the DT cord-277555-tsd6npma 53 16 above above RB cord-277555-tsd6npma 53 17 - - HYPH cord-277555-tsd6npma 53 18 mentioned mention VBN cord-277555-tsd6npma 53 19 drug drug NN cord-277555-tsd6npma 53 20 azithromycin azithromycin NN cord-277555-tsd6npma 53 21 , , , cord-277555-tsd6npma 53 22 and and CC cord-277555-tsd6npma 53 23 may may MD cord-277555-tsd6npma 53 24 present present VB cord-277555-tsd6npma 53 25 with with IN cord-277555-tsd6npma 53 26 hypokalaemia hypokalaemia NN cord-277555-tsd6npma 53 27 . . . cord-277555-tsd6npma 54 1 Finally finally RB cord-277555-tsd6npma 54 2 , , , cord-277555-tsd6npma 54 3 genetic genetic JJ cord-277555-tsd6npma 54 4 factors factor NNS cord-277555-tsd6npma 54 5 particularly particularly RB cord-277555-tsd6npma 54 6 present present JJ cord-277555-tsd6npma 54 7 in in IN cord-277555-tsd6npma 54 8 black black JJ cord-277555-tsd6npma 54 9 African african JJ cord-277555-tsd6npma 54 10 individuals individual NNS cord-277555-tsd6npma 54 11 may may MD cord-277555-tsd6npma 54 12 predispose predispose VB cord-277555-tsd6npma 54 13 them -PRON- PRP cord-277555-tsd6npma 54 14 to to IN cord-277555-tsd6npma 54 15 accumulation accumulation NN cord-277555-tsd6npma 54 16 of of IN cord-277555-tsd6npma 54 17 all all PDT cord-277555-tsd6npma 54 18 these these DT cord-277555-tsd6npma 54 19 effects effect NNS cord-277555-tsd6npma 54 20 [ [ -LRB- cord-277555-tsd6npma 54 21 22 22 CD cord-277555-tsd6npma 54 22 ] ] -RRB- cord-277555-tsd6npma 54 23 . . . cord-277555-tsd6npma 55 1 The the DT cord-277555-tsd6npma 55 2 hypothesis hypothesis NN cord-277555-tsd6npma 55 3 that that IN cord-277555-tsd6npma 55 4 QT qt NN cord-277555-tsd6npma 55 5 - - HYPH cord-277555-tsd6npma 55 6 prolonging prolong VBG cord-277555-tsd6npma 55 7 factors factor NNS cord-277555-tsd6npma 55 8 , , , cord-277555-tsd6npma 55 9 as as IN cord-277555-tsd6npma 55 10 mentioned mention VBN cord-277555-tsd6npma 55 11 above above RB cord-277555-tsd6npma 55 12 , , , cord-277555-tsd6npma 55 13 are be VBP cord-277555-tsd6npma 55 14 imperative imperative JJ cord-277555-tsd6npma 55 15 in in IN cord-277555-tsd6npma 56 1 COVID-19 covid-19 JJ cord-277555-tsd6npma 56 2 patients patient NNS cord-277555-tsd6npma 56 3 is be VBZ cord-277555-tsd6npma 56 4 underscored underscore VBN cord-277555-tsd6npma 56 5 by by IN cord-277555-tsd6npma 56 6 the the DT cord-277555-tsd6npma 56 7 fact fact NN cord-277555-tsd6npma 56 8 that that IN cord-277555-tsd6npma 56 9 the the DT cord-277555-tsd6npma 56 10 baseline baseline NN cord-277555-tsd6npma 56 11 mean mean NN cord-277555-tsd6npma 56 12 QTc qtc NN cord-277555-tsd6npma 56 13 interval interval NN cord-277555-tsd6npma 56 14 in in IN cord-277555-tsd6npma 56 15 COVID-19 covid-19 JJ cord-277555-tsd6npma 56 16 patients patient NNS cord-277555-tsd6npma 56 17 as as IN cord-277555-tsd6npma 56 18 presented present VBN cord-277555-tsd6npma 56 19 in in IN cord-277555-tsd6npma 56 20 both both DT cord-277555-tsd6npma 56 21 Dutch dutch JJ cord-277555-tsd6npma 56 22 studies study NNS cord-277555-tsd6npma 56 23 [ [ -LRB- cord-277555-tsd6npma 56 24 15 15 CD cord-277555-tsd6npma 56 25 , , , cord-277555-tsd6npma 56 26 16 16 CD cord-277555-tsd6npma 56 27 ] ] -RRB- cord-277555-tsd6npma 56 28 is be VBZ cord-277555-tsd6npma 56 29 much much RB cord-277555-tsd6npma 56 30 longer long JJR cord-277555-tsd6npma 56 31 ( ( -LRB- cord-277555-tsd6npma 56 32 in in IN cord-277555-tsd6npma 56 33 the the DT cord-277555-tsd6npma 56 34 range range NN cord-277555-tsd6npma 56 35 440 440 CD cord-277555-tsd6npma 56 36 - - SYM cord-277555-tsd6npma 56 37 450 450 CD cord-277555-tsd6npma 56 38 ms m NNS cord-277555-tsd6npma 56 39 ) ) -RRB- cord-277555-tsd6npma 56 40 than than IN cord-277555-tsd6npma 56 41 in in IN cord-277555-tsd6npma 56 42 studies study NNS cord-277555-tsd6npma 56 43 with with IN cord-277555-tsd6npma 56 44 volunteers volunteer NNS cord-277555-tsd6npma 56 45 ( ( -LRB- cord-277555-tsd6npma 56 46 400 400 CD cord-277555-tsd6npma 56 47 - - SYM cord-277555-tsd6npma 56 48 410 410 CD cord-277555-tsd6npma 56 49 ms m NNS cord-277555-tsd6npma 56 50 ) ) -RRB- cord-277555-tsd6npma 56 51 [ [ -LRB- cord-277555-tsd6npma 56 52 6 6 CD cord-277555-tsd6npma 56 53 ] ] -RRB- cord-277555-tsd6npma 56 54 . . . cord-277555-tsd6npma 57 1 How how WRB cord-277555-tsd6npma 57 2 should should MD cord-277555-tsd6npma 57 3 we -PRON- PRP cord-277555-tsd6npma 57 4 proceed proceed VB cord-277555-tsd6npma 57 5 ? ? . cord-277555-tsd6npma 58 1 Clearly clearly RB cord-277555-tsd6npma 58 2 it -PRON- PRP cord-277555-tsd6npma 58 3 is be VBZ cord-277555-tsd6npma 58 4 a a DT cord-277555-tsd6npma 58 5 bad bad JJ cord-277555-tsd6npma 58 6 idea idea NN cord-277555-tsd6npma 58 7 to to TO cord-277555-tsd6npma 58 8 provide provide VB cord-277555-tsd6npma 58 9 every every DT cord-277555-tsd6npma 58 10 citizen citizen NN cord-277555-tsd6npma 58 11 with with IN cord-277555-tsd6npma 58 12 either either CC cord-277555-tsd6npma 58 13 CQ CQ NNP cord-277555-tsd6npma 58 14 or or CC cord-277555-tsd6npma 58 15 HCQ HCQ NNP cord-277555-tsd6npma 58 16 before before IN cord-277555-tsd6npma 58 17 more more JJR cord-277555-tsd6npma 58 18 information information NN cord-277555-tsd6npma 58 19 on on IN cord-277555-tsd6npma 58 20 their -PRON- PRP$ cord-277555-tsd6npma 58 21 efficacy efficacy NN cord-277555-tsd6npma 58 22 is be VBZ cord-277555-tsd6npma 58 23 known know VBN cord-277555-tsd6npma 58 24 . . . cord-277555-tsd6npma 59 1 Instead instead RB cord-277555-tsd6npma 59 2 , , , cord-277555-tsd6npma 59 3 large large JJ cord-277555-tsd6npma 59 4 - - HYPH cord-277555-tsd6npma 59 5 scale scale NN cord-277555-tsd6npma 59 6 , , , cord-277555-tsd6npma 59 7 randomised randomised JJ cord-277555-tsd6npma 59 8 , , , cord-277555-tsd6npma 59 9 double double JJ cord-277555-tsd6npma 59 10 - - HYPH cord-277555-tsd6npma 59 11 blinded blinded JJ cord-277555-tsd6npma 59 12 trials trial NNS cord-277555-tsd6npma 59 13 are be VBP cord-277555-tsd6npma 59 14 the the DT cord-277555-tsd6npma 59 15 highest high JJS cord-277555-tsd6npma 59 16 priority priority NN cord-277555-tsd6npma 59 17 in in IN cord-277555-tsd6npma 59 18 order order NN cord-277555-tsd6npma 59 19 to to TO cord-277555-tsd6npma 59 20 prove prove VB cord-277555-tsd6npma 59 21 the the DT cord-277555-tsd6npma 59 22 efficacy efficacy NN cord-277555-tsd6npma 59 23 of of IN cord-277555-tsd6npma 59 24 either either DT cord-277555-tsd6npma 59 25 drug drug NN cord-277555-tsd6npma 59 26 [ [ -LRB- cord-277555-tsd6npma 59 27 1 1 CD cord-277555-tsd6npma 59 28 ] ] -RRB- cord-277555-tsd6npma 59 29 . . . cord-277555-tsd6npma 60 1 These these DT cord-277555-tsd6npma 60 2 trials trial NNS cord-277555-tsd6npma 60 3 should should MD cord-277555-tsd6npma 60 4 focus focus VB cord-277555-tsd6npma 60 5 on on IN cord-277555-tsd6npma 60 6 mildly mildly RB cord-277555-tsd6npma 60 7 affected affected JJ cord-277555-tsd6npma 60 8 patients patient NNS cord-277555-tsd6npma 60 9 early early RB cord-277555-tsd6npma 60 10 after after IN cord-277555-tsd6npma 60 11 disease disease NN cord-277555-tsd6npma 60 12 onset onset NN cord-277555-tsd6npma 60 13 in in IN cord-277555-tsd6npma 60 14 order order NN cord-277555-tsd6npma 60 15 to to TO cord-277555-tsd6npma 60 16 demonstrate demonstrate VB cord-277555-tsd6npma 60 17 whether whether IN cord-277555-tsd6npma 60 18 these these DT cord-277555-tsd6npma 60 19 drugs drug NNS cord-277555-tsd6npma 60 20 can can MD cord-277555-tsd6npma 60 21 cure cure VB cord-277555-tsd6npma 60 22 an an DT cord-277555-tsd6npma 60 23 early early JJ cord-277555-tsd6npma 60 24 infection infection NN cord-277555-tsd6npma 60 25 with with IN cord-277555-tsd6npma 60 26 SARS SARS NNP cord-277555-tsd6npma 60 27 - - HYPH cord-277555-tsd6npma 60 28 CoV-2 CoV-2 NNP cord-277555-tsd6npma 60 29 . . . cord-277555-tsd6npma 61 1 Secondly secondly RB cord-277555-tsd6npma 61 2 , , , cord-277555-tsd6npma 61 3 similar similar JJ cord-277555-tsd6npma 61 4 studies study NNS cord-277555-tsd6npma 61 5 should should MD cord-277555-tsd6npma 61 6 be be VB cord-277555-tsd6npma 61 7 performed perform VBN cord-277555-tsd6npma 61 8 in in IN cord-277555-tsd6npma 61 9 individuals individual NNS cord-277555-tsd6npma 61 10 with with IN cord-277555-tsd6npma 61 11 a a DT cord-277555-tsd6npma 61 12 high high JJ cord-277555-tsd6npma 61 13 level level NN cord-277555-tsd6npma 61 14 of of IN cord-277555-tsd6npma 61 15 exposure exposure NN cord-277555-tsd6npma 61 16 ( ( -LRB- cord-277555-tsd6npma 61 17 e.g. e.g. IN cord-277555-tsd6npma 61 18 healthcare healthcare NN cord-277555-tsd6npma 61 19 workers worker NNS cord-277555-tsd6npma 61 20 ) ) -RRB- cord-277555-tsd6npma 61 21 to to TO cord-277555-tsd6npma 61 22 demonstrate demonstrate VB cord-277555-tsd6npma 61 23 whether whether IN cord-277555-tsd6npma 61 24 these these DT cord-277555-tsd6npma 61 25 drugs drug NNS cord-277555-tsd6npma 61 26 are be VBP cord-277555-tsd6npma 61 27 effective effective JJ cord-277555-tsd6npma 61 28 in in IN cord-277555-tsd6npma 61 29 preventing prevent VBG cord-277555-tsd6npma 61 30 an an DT cord-277555-tsd6npma 61 31 infection infection NN cord-277555-tsd6npma 61 32 with with IN cord-277555-tsd6npma 61 33 SARS SARS NNP cord-277555-tsd6npma 61 34 - - HYPH cord-277555-tsd6npma 61 35 CoV-2 CoV-2 NNP cord-277555-tsd6npma 61 36 . . . cord-277555-tsd6npma 62 1 In in IN cord-277555-tsd6npma 62 2 both both DT cord-277555-tsd6npma 62 3 groups group NNS cord-277555-tsd6npma 62 4 careful careful JJ cord-277555-tsd6npma 62 5 ECG ECG NNP cord-277555-tsd6npma 62 6 monitoring monitoring NN cord-277555-tsd6npma 62 7 is be VBZ cord-277555-tsd6npma 62 8 warranted warrant VBN cord-277555-tsd6npma 62 9 to to TO cord-277555-tsd6npma 62 10 prevent prevent VB cord-277555-tsd6npma 62 11 excessive excessive JJ cord-277555-tsd6npma 62 12 QTc qtc NN cord-277555-tsd6npma 62 13 prolongation prolongation NN cord-277555-tsd6npma 62 14 and and CC cord-277555-tsd6npma 62 15 , , , cord-277555-tsd6npma 62 16 with with IN cord-277555-tsd6npma 62 17 longer long JJR cord-277555-tsd6npma 62 18 treatment treatment NN cord-277555-tsd6npma 62 19 in in IN cord-277555-tsd6npma 62 20 the the DT cord-277555-tsd6npma 62 21 preexposure preexposure NN cord-277555-tsd6npma 62 22 group group NN cord-277555-tsd6npma 62 23 , , , cord-277555-tsd6npma 62 24 conduction conduction NN cord-277555-tsd6npma 62 25 disturbances disturbance NNS cord-277555-tsd6npma 62 26 . . . cord-277555-tsd6npma 63 1 For for IN cord-277555-tsd6npma 63 2 these these DT cord-277555-tsd6npma 63 3 prophylactic prophylactic JJ cord-277555-tsd6npma 63 4 studies study NNS cord-277555-tsd6npma 63 5 the the DT cord-277555-tsd6npma 63 6 same same JJ cord-277555-tsd6npma 63 7 motto motto NN cord-277555-tsd6npma 63 8 applies apply VBZ cord-277555-tsd6npma 63 9 as as IN cord-277555-tsd6npma 63 10 for for IN cord-277555-tsd6npma 63 11 the the DT cord-277555-tsd6npma 63 12 aforementioned aforementioned JJ cord-277555-tsd6npma 63 13 presidents president NNS cord-277555-tsd6npma 63 14 : : : cord-277555-tsd6npma 63 15 ' ' '' cord-277555-tsd6npma 63 16 first first RB cord-277555-tsd6npma 63 17 , , , cord-277555-tsd6npma 63 18 do do VB cord-277555-tsd6npma 63 19 no no DT cord-277555-tsd6npma 63 20 harm harm NN cord-277555-tsd6npma 63 21 ' ' '' cord-277555-tsd6npma 63 22 [ [ -LRB- cord-277555-tsd6npma 63 23 23 23 CD cord-277555-tsd6npma 63 24 ] ] -RRB- cord-277555-tsd6npma 63 25 . . . cord-277555-tsd6npma 64 1 Open open VB cord-277555-tsd6npma 64 2 Access Access NNP cord-277555-tsd6npma 65 1 This this DT cord-277555-tsd6npma 65 2 article article NN cord-277555-tsd6npma 65 3 is be VBZ cord-277555-tsd6npma 65 4 licensed license VBN cord-277555-tsd6npma 65 5 under under IN cord-277555-tsd6npma 65 6 a a DT cord-277555-tsd6npma 65 7 Creative Creative NNP cord-277555-tsd6npma 65 8 Commons Commons NNP cord-277555-tsd6npma 65 9 Attribution Attribution NNP cord-277555-tsd6npma 65 10 4.0 4.0 CD cord-277555-tsd6npma 65 11 International International NNP cord-277555-tsd6npma 65 12 License License NNP cord-277555-tsd6npma 65 13 , , , cord-277555-tsd6npma 65 14 which which WDT cord-277555-tsd6npma 65 15 permits permit VBZ cord-277555-tsd6npma 65 16 use use NN cord-277555-tsd6npma 65 17 , , , cord-277555-tsd6npma 65 18 sharing sharing NN cord-277555-tsd6npma 65 19 , , , cord-277555-tsd6npma 65 20 adaptation adaptation NN cord-277555-tsd6npma 65 21 , , , cord-277555-tsd6npma 65 22 distribution distribution NN cord-277555-tsd6npma 65 23 and and CC cord-277555-tsd6npma 65 24 reproduction reproduction NN cord-277555-tsd6npma 65 25 in in IN cord-277555-tsd6npma 65 26 any any DT cord-277555-tsd6npma 65 27 medium medium NN cord-277555-tsd6npma 65 28 or or CC cord-277555-tsd6npma 65 29 format format NN cord-277555-tsd6npma 65 30 , , , cord-277555-tsd6npma 65 31 as as RB cord-277555-tsd6npma 65 32 long long RB cord-277555-tsd6npma 65 33 as as IN cord-277555-tsd6npma 65 34 you -PRON- PRP cord-277555-tsd6npma 65 35 give give VBP cord-277555-tsd6npma 65 36 appropriate appropriate JJ cord-277555-tsd6npma 65 37 credit credit NN cord-277555-tsd6npma 65 38 to to IN cord-277555-tsd6npma 65 39 the the DT cord-277555-tsd6npma 65 40 original original JJ cord-277555-tsd6npma 65 41 author(s author(s NNP cord-277555-tsd6npma 65 42 ) ) -RRB- cord-277555-tsd6npma 65 43 and and CC cord-277555-tsd6npma 65 44 the the DT cord-277555-tsd6npma 65 45 source source NN cord-277555-tsd6npma 65 46 , , , cord-277555-tsd6npma 65 47 provide provide VB cord-277555-tsd6npma 65 48 a a DT cord-277555-tsd6npma 65 49 link link NN cord-277555-tsd6npma 65 50 to to IN cord-277555-tsd6npma 65 51 the the DT cord-277555-tsd6npma 65 52 Creative Creative NNP cord-277555-tsd6npma 65 53 Commons Commons NNP cord-277555-tsd6npma 65 54 licence licence NN cord-277555-tsd6npma 65 55 , , , cord-277555-tsd6npma 65 56 and and CC cord-277555-tsd6npma 65 57 indicate indicate VBP cord-277555-tsd6npma 65 58 if if IN cord-277555-tsd6npma 65 59 changes change NNS cord-277555-tsd6npma 65 60 were be VBD cord-277555-tsd6npma 65 61 made make VBN cord-277555-tsd6npma 65 62 . . . cord-277555-tsd6npma 66 1 The the DT cord-277555-tsd6npma 66 2 images image NNS cord-277555-tsd6npma 66 3 or or CC cord-277555-tsd6npma 66 4 other other JJ cord-277555-tsd6npma 66 5 third third JJ cord-277555-tsd6npma 66 6 party party NN cord-277555-tsd6npma 66 7 material material NN cord-277555-tsd6npma 66 8 in in IN cord-277555-tsd6npma 66 9 this this DT cord-277555-tsd6npma 66 10 article article NN cord-277555-tsd6npma 66 11 are be VBP cord-277555-tsd6npma 66 12 included include VBN cord-277555-tsd6npma 66 13 in in IN cord-277555-tsd6npma 66 14 the the DT cord-277555-tsd6npma 66 15 article article NN cord-277555-tsd6npma 66 16 's 's POS cord-277555-tsd6npma 66 17 Creative Creative NNP cord-277555-tsd6npma 66 18 Commons Commons NNP cord-277555-tsd6npma 66 19 licence licence NN cord-277555-tsd6npma 66 20 , , , cord-277555-tsd6npma 66 21 unless unless IN cord-277555-tsd6npma 66 22 indicated indicate VBN cord-277555-tsd6npma 66 23 otherwise otherwise RB cord-277555-tsd6npma 66 24 in in IN cord-277555-tsd6npma 66 25 a a DT cord-277555-tsd6npma 66 26 credit credit NN cord-277555-tsd6npma 66 27 line line NN cord-277555-tsd6npma 66 28 to to IN cord-277555-tsd6npma 66 29 the the DT cord-277555-tsd6npma 66 30 material material NN cord-277555-tsd6npma 66 31 . . . cord-277555-tsd6npma 67 1 If if IN cord-277555-tsd6npma 67 2 material material NN cord-277555-tsd6npma 67 3 is be VBZ cord-277555-tsd6npma 67 4 not not RB cord-277555-tsd6npma 67 5 included include VBN cord-277555-tsd6npma 67 6 in in IN cord-277555-tsd6npma 67 7 the the DT cord-277555-tsd6npma 67 8 article article NN cord-277555-tsd6npma 67 9 's 's POS cord-277555-tsd6npma 67 10 Creative Creative NNP cord-277555-tsd6npma 67 11 Commons Commons NNP cord-277555-tsd6npma 67 12 licence licence NN cord-277555-tsd6npma 67 13 and and CC cord-277555-tsd6npma 67 14 your -PRON- PRP$ cord-277555-tsd6npma 67 15 intended intend VBN cord-277555-tsd6npma 67 16 use use NN cord-277555-tsd6npma 67 17 is be VBZ cord-277555-tsd6npma 67 18 not not RB cord-277555-tsd6npma 67 19 permitted permit VBN cord-277555-tsd6npma 67 20 by by IN cord-277555-tsd6npma 67 21 statutory statutory JJ cord-277555-tsd6npma 67 22 regulation regulation NN cord-277555-tsd6npma 67 23 or or CC cord-277555-tsd6npma 67 24 exceeds exceed VBZ cord-277555-tsd6npma 67 25 the the DT cord-277555-tsd6npma 67 26 permitted permit VBN cord-277555-tsd6npma 67 27 use use NN cord-277555-tsd6npma 67 28 , , , cord-277555-tsd6npma 67 29 you -PRON- PRP cord-277555-tsd6npma 67 30 will will MD cord-277555-tsd6npma 67 31 need need VB cord-277555-tsd6npma 67 32 to to TO cord-277555-tsd6npma 67 33 obtain obtain VB cord-277555-tsd6npma 67 34 permission permission NN cord-277555-tsd6npma 67 35 directly directly RB cord-277555-tsd6npma 67 36 from from IN cord-277555-tsd6npma 67 37 the the DT cord-277555-tsd6npma 67 38 copyright copyright NN cord-277555-tsd6npma 67 39 holder holder NN cord-277555-tsd6npma 67 40 . . . cord-277555-tsd6npma 68 1 To to TO cord-277555-tsd6npma 68 2 view view VB cord-277555-tsd6npma 68 3 a a DT cord-277555-tsd6npma 68 4 copy copy NN cord-277555-tsd6npma 68 5 of of IN cord-277555-tsd6npma 68 6 this this DT cord-277555-tsd6npma 68 7 licence licence NN cord-277555-tsd6npma 68 8 , , , cord-277555-tsd6npma 68 9 visit visit VB cord-277555-tsd6npma 68 10 http://creativecommons.org/licenses/by/4.0/. http://creativecommons.org/licenses/by/4.0/. NNP cord-277555-tsd6npma 68 11 Finding find VBG cord-277555-tsd6npma 68 12 effective effective JJ cord-277555-tsd6npma 68 13 treatments treatment NNS cord-277555-tsd6npma 68 14 for for IN cord-277555-tsd6npma 68 15 COVID-19 covid-19 NN cord-277555-tsd6npma 68 16 . . . cord-277555-tsd6npma 69 1 Scientific scientific JJ cord-277555-tsd6npma 69 2 integrity integrity NN cord-277555-tsd6npma 69 3 and and CC cord-277555-tsd6npma 69 4 public public JJ cord-277555-tsd6npma 69 5 confidence confidence NN cord-277555-tsd6npma 69 6 in in IN cord-277555-tsd6npma 69 7 a a DT cord-277555-tsd6npma 69 8 time time NN cord-277555-tsd6npma 69 9 of of IN cord-277555-tsd6npma 69 10 crisis crisis NN cord-277555-tsd6npma 69 11 Inhibition inhibition NN cord-277555-tsd6npma 69 12 of of IN cord-277555-tsd6npma 69 13 hERG herg PRP cord-277555-tsd6npma 69 14 K+ k+ JJ cord-277555-tsd6npma 69 15 currents current NNS cord-277555-tsd6npma 69 16 by by IN cord-277555-tsd6npma 69 17 antimalarial antimalarial JJ cord-277555-tsd6npma 69 18 drugs drug NNS cord-277555-tsd6npma 69 19 in in IN cord-277555-tsd6npma 69 20 stably stably RB cord-277555-tsd6npma 69 21 transfected transfecte VBN cord-277555-tsd6npma 69 22 HEK293 HEK293 NNP cord-277555-tsd6npma 69 23 cells cell VBZ cord-277555-tsd6npma 69 24 Cardiac cardiac JJ cord-277555-tsd6npma 69 25 complications complication NNS cord-277555-tsd6npma 69 26 attributed attribute VBN cord-277555-tsd6npma 69 27 to to IN cord-277555-tsd6npma 69 28 chloroquine chloroquine NN cord-277555-tsd6npma 69 29 and and CC cord-277555-tsd6npma 69 30 hydroxychloroquine hydroxychloroquine NN cord-277555-tsd6npma 69 31 : : : cord-277555-tsd6npma 69 32 a a DT cord-277555-tsd6npma 69 33 systematic systematic JJ cord-277555-tsd6npma 69 34 review review NN cord-277555-tsd6npma 69 35 of of IN cord-277555-tsd6npma 69 36 the the DT cord-277555-tsd6npma 69 37 literature literature NN cord-277555-tsd6npma 69 38 Randomized randomized JJ cord-277555-tsd6npma 69 39 doseranging doseranging NN cord-277555-tsd6npma 69 40 controlled control VBN cord-277555-tsd6npma 69 41 trial trial NN cord-277555-tsd6npma 69 42 of of IN cord-277555-tsd6npma 69 43 AQ-13 AQ-13 NNP cord-277555-tsd6npma 69 44 , , , cord-277555-tsd6npma 69 45 a a DT cord-277555-tsd6npma 69 46 candidate candidate NN cord-277555-tsd6npma 69 47 antimalarial antimalarial JJ cord-277555-tsd6npma 69 48 , , , cord-277555-tsd6npma 69 49 and and CC cord-277555-tsd6npma 69 50 chloroquine chloroquine NN cord-277555-tsd6npma 69 51 in in IN cord-277555-tsd6npma 69 52 healthy healthy JJ cord-277555-tsd6npma 69 53 volunteers volunteer NNS cord-277555-tsd6npma 69 54 Safety Safety NNP cord-277555-tsd6npma 69 55 of of IN cord-277555-tsd6npma 69 56 hydroxychloroquine hydroxychloroquine NNP cord-277555-tsd6npma 69 57 , , , cord-277555-tsd6npma 69 58 alone alone JJ cord-277555-tsd6npma 69 59 and and CC cord-277555-tsd6npma 69 60 in in IN cord-277555-tsd6npma 69 61 combination combination NN cord-277555-tsd6npma 69 62 with with IN cord-277555-tsd6npma 69 63 azithromycin azithromycin NNP cord-277555-tsd6npma 69 64 , , , cord-277555-tsd6npma 69 65 in in IN cord-277555-tsd6npma 69 66 light light NN cord-277555-tsd6npma 69 67 of of IN cord-277555-tsd6npma 69 68 rapid rapid JJ cord-277555-tsd6npma 69 69 wide wide JJ cord-277555-tsd6npma 69 70 - - HYPH cord-277555-tsd6npma 69 71 spread spread VBN cord-277555-tsd6npma 69 72 use use NN cord-277555-tsd6npma 69 73 for for IN cord-277555-tsd6npma 69 74 COVID-19 COVID-19 NNP cord-277555-tsd6npma 69 75 : : : cord-277555-tsd6npma 69 76 a a DT cord-277555-tsd6npma 69 77 multinational multinational JJ cord-277555-tsd6npma 69 78 , , , cord-277555-tsd6npma 69 79 network network NN cord-277555-tsd6npma 69 80 cohort cohort NN cord-277555-tsd6npma 69 81 and and CC cord-277555-tsd6npma 69 82 self self NN cord-277555-tsd6npma 69 83 - - HYPH cord-277555-tsd6npma 69 84 controlled control VBN cord-277555-tsd6npma 69 85 case case NN cord-277555-tsd6npma 69 86 series series NNP cord-277555-tsd6npma 69 87 study study NN cord-277555-tsd6npma 69 88 chloroquine chloroquine NN cord-277555-tsd6npma 69 89 phosphate phosphate NN cord-277555-tsd6npma 69 90 has have VBZ cord-277555-tsd6npma 69 91 shown show VBN cord-277555-tsd6npma 69 92 apparent apparent JJ cord-277555-tsd6npma 69 93 efficacy efficacy NN cord-277555-tsd6npma 69 94 in in IN cord-277555-tsd6npma 69 95 treatment treatment NN cord-277555-tsd6npma 69 96 of of IN cord-277555-tsd6npma 69 97 COVID-19 covid-19 JJ cord-277555-tsd6npma 69 98 associated associated JJ cord-277555-tsd6npma 69 99 pneumonia pneumonia NN cord-277555-tsd6npma 69 100 in in IN cord-277555-tsd6npma 69 101 clinical clinical JJ cord-277555-tsd6npma 69 102 studies study NNS cord-277555-tsd6npma 69 103 Hydroxychloroquine Hydroxychloroquine NNP cord-277555-tsd6npma 69 104 and and CC cord-277555-tsd6npma 69 105 azithromycin azithromycin NNP cord-277555-tsd6npma 69 106 as as IN cord-277555-tsd6npma 69 107 a a DT cord-277555-tsd6npma 69 108 treatment treatment NN cord-277555-tsd6npma 69 109 of of IN cord-277555-tsd6npma 69 110 COVID-19 covid-19 NN cord-277555-tsd6npma 69 111 : : : cord-277555-tsd6npma 69 112 results result NNS cord-277555-tsd6npma 69 113 of of IN cord-277555-tsd6npma 69 114 an an DT cord-277555-tsd6npma 69 115 open open JJ cord-277555-tsd6npma 69 116 - - HYPH cord-277555-tsd6npma 69 117 label label NN cord-277555-tsd6npma 69 118 nonrandomized nonrandomize VBN cord-277555-tsd6npma 69 119 clinical clinical JJ cord-277555-tsd6npma 69 120 trial trial NN cord-277555-tsd6npma 69 121 Efficacy Efficacy NNP cord-277555-tsd6npma 69 122 of of IN cord-277555-tsd6npma 69 123 hydroxychloroquine hydroxychloroquine NN cord-277555-tsd6npma 69 124 in in IN cord-277555-tsd6npma 69 125 patients patient NNS cord-277555-tsd6npma 69 126 with with IN cord-277555-tsd6npma 69 127 COVID-19 covid-19 NN cord-277555-tsd6npma 69 128 : : : cord-277555-tsd6npma 69 129 results result NNS cord-277555-tsd6npma 69 130 of of IN cord-277555-tsd6npma 69 131 a a DT cord-277555-tsd6npma 69 132 randomized randomized JJ cord-277555-tsd6npma 69 133 clinical clinical JJ cord-277555-tsd6npma 69 134 trial trial NN cord-277555-tsd6npma 69 135 Association Association NNP cord-277555-tsd6npma 69 136 of of IN cord-277555-tsd6npma 69 137 treatment treatment NN cord-277555-tsd6npma 69 138 with with IN cord-277555-tsd6npma 69 139 hydroxychloroquine hydroxychloroquine NNP cord-277555-tsd6npma 69 140 or or CC cord-277555-tsd6npma 69 141 azithromycin azithromycin NN cord-277555-tsd6npma 69 142 with with IN cord-277555-tsd6npma 69 143 in in IN cord-277555-tsd6npma 69 144 - - HYPH cord-277555-tsd6npma 69 145 hospital hospital NN cord-277555-tsd6npma 69 146 mortality mortality NN cord-277555-tsd6npma 69 147 in in IN cord-277555-tsd6npma 69 148 patients patient NNS cord-277555-tsd6npma 69 149 with with IN cord-277555-tsd6npma 69 150 COVID-19 covid-19 CD cord-277555-tsd6npma 69 151 in in IN cord-277555-tsd6npma 69 152 New New NNP cord-277555-tsd6npma 69 153 York York NNP cord-277555-tsd6npma 69 154 State State NNP cord-277555-tsd6npma 69 155 Outcomes Outcomes NNPS cord-277555-tsd6npma 69 156 of of IN cord-277555-tsd6npma 69 157 hydroxychloroquine hydroxychloroquine NN cord-277555-tsd6npma 69 158 usage usage NN cord-277555-tsd6npma 69 159 in in IN cord-277555-tsd6npma 69 160 United United NNP cord-277555-tsd6npma 69 161 States States NNP cord-277555-tsd6npma 69 162 veterans veteran NNS cord-277555-tsd6npma 69 163 hospitalized hospitalize VBN cord-277555-tsd6npma 69 164 with with IN cord-277555-tsd6npma 69 165 Covid-19 Covid-19 NNP cord-277555-tsd6npma 69 166 Hydroxychloroquine Hydroxychloroquine NNP cord-277555-tsd6npma 69 167 in in IN cord-277555-tsd6npma 69 168 patients patient NNS cord-277555-tsd6npma 69 169 with with IN cord-277555-tsd6npma 69 170 mainly mainly RB cord-277555-tsd6npma 69 171 mild mild JJ cord-277555-tsd6npma 69 172 to to IN cord-277555-tsd6npma 69 173 moderate moderate JJ cord-277555-tsd6npma 69 174 coronavirus coronavirus NN cord-277555-tsd6npma 69 175 disease disease NN cord-277555-tsd6npma 69 176 2019 2019 CD cord-277555-tsd6npma 69 177 : : : cord-277555-tsd6npma 69 178 open open JJ cord-277555-tsd6npma 69 179 label label NN cord-277555-tsd6npma 69 180 , , , cord-277555-tsd6npma 69 181 randomised randomised JJ cord-277555-tsd6npma 69 182 controlled control VBN cord-277555-tsd6npma 69 183 trial trial NN cord-277555-tsd6npma 69 184 A a DT cord-277555-tsd6npma 69 185 systematic systematic JJ cord-277555-tsd6npma 69 186 review review NN cord-277555-tsd6npma 69 187 on on IN cord-277555-tsd6npma 69 188 use use NN cord-277555-tsd6npma 69 189 of of IN cord-277555-tsd6npma 69 190 aminoquinolines aminoquinoline NNS cord-277555-tsd6npma 69 191 for for IN cord-277555-tsd6npma 69 192 the the DT cord-277555-tsd6npma 69 193 therapeutic therapeutic JJ cord-277555-tsd6npma 69 194 management management NN cord-277555-tsd6npma 69 195 of of IN cord-277555-tsd6npma 69 196 COVID-19 COVID-19 NNP cord-277555-tsd6npma 69 197 : : : cord-277555-tsd6npma 69 198 efficacy efficacy NN cord-277555-tsd6npma 69 199 , , , cord-277555-tsd6npma 69 200 safety safety NN cord-277555-tsd6npma 69 201 and and CC cord-277555-tsd6npma 69 202 clinical clinical JJ cord-277555-tsd6npma 69 203 trials trial NNS cord-277555-tsd6npma 70 1 Chloroquine chloroquine NN cord-277555-tsd6npma 70 2 - - HYPH cord-277555-tsd6npma 70 3 induced induce VBN cord-277555-tsd6npma 70 4 QTc qtc NN cord-277555-tsd6npma 70 5 prolongation prolongation NN cord-277555-tsd6npma 70 6 in in IN cord-277555-tsd6npma 70 7 COVID-19 covid-19 JJ cord-277555-tsd6npma 70 8 patients patient NNS cord-277555-tsd6npma 71 1 The the DT cord-277555-tsd6npma 71 2 risk risk NN cord-277555-tsd6npma 71 3 for for IN cord-277555-tsd6npma 71 4 QTc qtc NN cord-277555-tsd6npma 71 5 interval interval NN cord-277555-tsd6npma 71 6 prolongation prolongation NN cord-277555-tsd6npma 71 7 in in IN cord-277555-tsd6npma 71 8 COVID-19 COVID-19 NNP cord-277555-tsd6npma 71 9 patients patient NNS cord-277555-tsd6npma 71 10 treated treat VBN cord-277555-tsd6npma 71 11 with with IN cord-277555-tsd6npma 71 12 chloroquine chloroquine NN cord-277555-tsd6npma 71 13 QT QT NNP cord-277555-tsd6npma 71 14 prolongation prolongation NN cord-277555-tsd6npma 71 15 , , , cord-277555-tsd6npma 71 16 torsades torsades FW cord-277555-tsd6npma 71 17 de de IN cord-277555-tsd6npma 71 18 pointes pointes FW cord-277555-tsd6npma 71 19 and and CC cord-277555-tsd6npma 71 20 sudden sudden JJ cord-277555-tsd6npma 71 21 death death NN cord-277555-tsd6npma 71 22 with with IN cord-277555-tsd6npma 71 23 short short JJ cord-277555-tsd6npma 71 24 courses course NNS cord-277555-tsd6npma 71 25 of of IN cord-277555-tsd6npma 71 26 chloroquine chloroquine NN cord-277555-tsd6npma 71 27 or or CC cord-277555-tsd6npma 71 28 hydroxychloroquine hydroxychloroquine NN cord-277555-tsd6npma 71 29 as as IN cord-277555-tsd6npma 71 30 used use VBN cord-277555-tsd6npma 71 31 in in IN cord-277555-tsd6npma 71 32 COVID-19 COVID-19 NNP cord-277555-tsd6npma 71 33 : : : cord-277555-tsd6npma 71 34 a a DT cord-277555-tsd6npma 71 35 systematic systematic JJ cord-277555-tsd6npma 71 36 review review NN cord-277555-tsd6npma 71 37 Chloroquine chloroquine NN cord-277555-tsd6npma 71 38 - - HYPH cord-277555-tsd6npma 71 39 induced induce VBN cord-277555-tsd6npma 71 40 torsade torsade NNP cord-277555-tsd6npma 71 41 de de IN cord-277555-tsd6npma 71 42 pointes pointes FW cord-277555-tsd6npma 71 43 in in IN cord-277555-tsd6npma 71 44 a a DT cord-277555-tsd6npma 71 45 COVID-19 covid-19 JJ cord-277555-tsd6npma 71 46 patient patient NN cord-277555-tsd6npma 71 47 SARS SARS NNP cord-277555-tsd6npma 71 48 - - HYPH cord-277555-tsd6npma 71 49 CoV-2 CoV-2 NNP cord-277555-tsd6npma 71 50 , , , cord-277555-tsd6npma 71 51 COVID-19 COVID-19 NNP cord-277555-tsd6npma 71 52 and and CC cord-277555-tsd6npma 71 53 inherited inherit VBD cord-277555-tsd6npma 71 54 arrhythmia arrhythmia NN cord-277555-tsd6npma 71 55 syndromes syndrome NNS cord-277555-tsd6npma 72 1 COVID-19 COVID-19 NNP cord-277555-tsd6npma 72 2 , , , cord-277555-tsd6npma 72 3 arrhythmicriskandinflammation arrhythmicriskandinflammation NNP cord-277555-tsd6npma 72 4 : : : cord-277555-tsd6npma 72 5 mindthegap mindthegap NNP cord-277555-tsd6npma 72 6 ! ! . cord-277555-tsd6npma 73 1 Circulation circulation NN cord-277555-tsd6npma 73 2 Cardiac Cardiac NNP cord-277555-tsd6npma 73 3 late late JJ cord-277555-tsd6npma 73 4 Na(+ Na(+ NNP cord-277555-tsd6npma 73 5 ) ) -RRB- cord-277555-tsd6npma 73 6 current current NN cord-277555-tsd6npma 73 7 : : : cord-277555-tsd6npma 74 1 proarrhythmic proarrhythmic NNP cord-277555-tsd6npma 74 2 effects effect NNS cord-277555-tsd6npma 74 3 , , , cord-277555-tsd6npma 74 4 roles role NNS cord-277555-tsd6npma 74 5 in in IN cord-277555-tsd6npma 74 6 long long JJ cord-277555-tsd6npma 74 7 QT qt NN cord-277555-tsd6npma 74 8 syndromes syndrome NNS cord-277555-tsd6npma 74 9 , , , cord-277555-tsd6npma 74 10 and and CC cord-277555-tsd6npma 74 11 pathological pathological JJ cord-277555-tsd6npma 74 12 relationship relationship NN cord-277555-tsd6npma 74 13 to to IN cord-277555-tsd6npma 74 14 CaMKII CaMKII NNP cord-277555-tsd6npma 74 15 and and CC cord-277555-tsd6npma 74 16 oxidative oxidative JJ cord-277555-tsd6npma 74 17 stress stress NN cord-277555-tsd6npma 74 18 Genetic genetic JJ cord-277555-tsd6npma 74 19 susceptibility susceptibility NN cord-277555-tsd6npma 74 20 for for IN cord-277555-tsd6npma 74 21 COVID-19-associated covid-19-associated JJ cord-277555-tsd6npma 74 22 sudden sudden JJ cord-277555-tsd6npma 74 23 cardiac cardiac JJ cord-277555-tsd6npma 74 24 death death NN cord-277555-tsd6npma 74 25 in in IN cord-277555-tsd6npma 74 26 African african JJ cord-277555-tsd6npma 74 27 Americans Americans NNPS cord-277555-tsd6npma 75 1 COVID-19 COVID-19 NNP cord-277555-tsd6npma 75 2 , , , cord-277555-tsd6npma 75 3 Clinical clinical JJ cord-277555-tsd6npma 75 4 trials trial NNS cord-277555-tsd6npma 75 5 and and CC cord-277555-tsd6npma 75 6 QT qt NN cord-277555-tsd6npma 75 7 - - HYPH cord-277555-tsd6npma 75 8 prolonging prolong VBG cord-277555-tsd6npma 75 9 prophylactic prophylactic JJ cord-277555-tsd6npma 75 10 therapy therapy NN cord-277555-tsd6npma 75 11 in in IN cord-277555-tsd6npma 75 12 healthy healthy JJ cord-277555-tsd6npma 75 13 subjects subject NNS cord-277555-tsd6npma 75 14 : : : cord-277555-tsd6npma 75 15 first first RB cord-277555-tsd6npma 75 16 , , , cord-277555-tsd6npma 75 17 do do VB cord-277555-tsd6npma 75 18 no no DT cord-277555-tsd6npma 75 19 harm harm NN