id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-259916-gr6v098c	Wang, Hongliang	Mechanisms of Cellular Membrane Reorganization to Support Hepatitis C Virus Replication	2016-05-20		.txt	text/plain	6186	252	33	Like all positive-sense RNA viruses, hepatitis C virus (HCV) induces host membrane alterations for its replication termed the membranous web (MW). This review will summarize the recent studies that have led to our current knowledge of the role of viral and host factors in the biogenesis of the MWs and discuss how HCV uses this specialized membrane structure for its replication. A later study of cells containing a subgenomic HCV replicon reported that the membrane alterations induced by HCV replication consisted in part of double-membrane vesicles (DMVs; Figure 1 ) with a diameter around 200 nm that were also positive on immunoelectron microscopy with antibodies against NS5A and double-stranded RNA (dsRNA) [15] . [10] first showed that expression of viral nonstructural proteins resulted in membrane alterations that morphologically resemble those observed in replicon cells, demonstrating that viral RNA replication is not required for membranous web formation. Expression of hepatitis C virus proteins induces distinct membrane alterations including a candidate viral replication complex	./cache/cord-259916-gr6v098c.txt	./txt/cord-259916-gr6v098c.txt