id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-260099-mthwab4p	Li, Yi	C-type lectin LSECtin interacts with DC-SIGNR and is involved in hepatitis C virus binding	2009-02-21		.txt	text/plain	3479	195	59	The present study suggests that LSECtin interaction with DC-SIGNR might contribute to HCV binding to liver sinusoidal endothelial cells. About a half of the DC-SIGNR-HEK293T cells were bound to the soluble Fc-LSECtin but not control-Fc protein, whereas only 6% of the mock cells were adhered to LSECtin (Fig. 1c) . Pre-incubation with the soluble LSECtin protein resulted in a dramatic decrease in the affinity of HCV E2 to the HEK293T-LSECtin cells (Fig. 3c) . Our present study suggests that LSECtin, a recently identified C-type lectin, could interact with DC-SIGNR and CD81 and was involved in HCV binding. previously reported that they could not detect the binding of HCV pseudotype particles to LSECtin expressed cells [14] , which is inconsistent with our results. In summary, the present study suggests that LSECtin interaction with DC-SIGNR might contribute to HCV binding to liver sinusoidal endothelial cells.	./cache/cord-260099-mthwab4p.txt	./txt/cord-260099-mthwab4p.txt