id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-273555-i1d4quos	Stättermayer, A. F.	Letter: does the IFNL4 gene discovery really provide a causal role for the IL28B haplotype blocks? Authors' reply	2014-02-04		.txt	text/plain	1159	64	47	Authors' reply SIRS, We thank Dr Galmozzi and Dr Lampertico for their comment on our recently published paper on the effect of the dinucleotide frameshift variant in ss469415590 in the interferon (IFN)-k4 gene on interferon/ribavirin treatment and its relationship with the two commonly used single nucleotide polymorphisms (SNP) in IL28B (rs12979860, rs8099917). 1, 2 We agree that our study does not provide insights on the causal relationship between IFNL4 and treatment response in patients with chronic hepatitis C virus (HCV) infection. We would like to remind them that up-regulation of intrahepatic interferon-stimulated genes (ISG) is associated with treatment failure in patients with chronic HCV, and levels of ISG are differently distributed according to different IL28B genotypes. 1 reported a randomised controlled trial comparing oral (100 mg twice daily ferrous sulphate for 3 months) or intravenous (1000 mg ferric carboxymaltose, single-dose infusion) iron supplementation and placebo for anaemia after nonvariceal upper gastrointestinal (GI) bleeding.	./cache/cord-273555-i1d4quos.txt	./txt/cord-273555-i1d4quos.txt