id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-312080-pu6m4qad	He, Bing	Three-dimensional cell culture models for investigating human viruses	2016-10-27		.txt	text/plain	9036	454	38	This review focuses on the recent progress of human virological research with 3D cell culture models, including human viral growth, replication, proliferation, infection, viral life cycle, virus-host interaction and the development of antiviral drugs. A multitude of research has shown that RWV-derived models utilizing human cells are a valuable tool for investigating viral growth, replication, viral infection, viral entry, the viability of virions and virus-host interaction (Margolis et al., 1997; Long et al., 1998; Nickerson et al., 2007; Straub et al., 2007; Barrila et al., 2010; Berto et al., 2013; Goodwin et al., 2015) . As keratinocytes are the main target cells for productive infection in vivo for VZV, characterization of viral replication in organotypic raft cultures of these cells represents a very relevant model for studying virus-host cell interactions and antiviral agents (Andrei et al., 2005) .	./cache/cord-312080-pu6m4qad.txt	./txt/cord-312080-pu6m4qad.txt