id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332422-s15o0hie	Belouzard, Sandrine	Hepatitis C virus entry into the hepatocyte	2011-11-07		.txt	text/plain	6987	365	47	HCV envelope glycoproteins are key determinants of HCV entry with a role in receptor binding and in mediating the fusion process between the viral envelope and an endosomal host cell membrane. Furthermore, functional non-infectious and capsidless structures, called subviral particles, can be produced when the HCV envelope glycoproteins are expressed alone in lipoprotein producing cell lines [8] , supporting the idea that HCV envelope glycoproteins play an active role during the budding process. The role of SRB1 in HCV entry was first suggested by its ability to mediate soluble E2 binding [13] and it was later confirmed by the inhibition of HCV infection with anti-SRB1 antibodies and by silencing of the protein in hepatoma cells (reviewed in [5, 26, 27] ). Virus-associated lipoproteins are likely playing a role in the early phase of HCV entry, whereas envelope glycoproteins are believed to take the lead after this initial step.	./cache/cord-332422-s15o0hie.txt	./txt/cord-332422-s15o0hie.txt