id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334493-rt7gqiev	Ikejiri, Masahiro	5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents	2007-11-15		.txt	text/plain	4869	242	61	On the basis of our previous study on antiviral agents against the severe acute respiratory syndrome (SARS) coronavirus, a series of nucleoside analogues whose 5′-hydroxyl groups are masked by various protective groups such as carboxylate, sulfonate, and ether were synthesized and evaluated to develop novel anti-hepatitis C virus (HCV) agents. Since the 5′-O-unmasked analogue (i.e., 6-chloropurine-2′-deoxyriboside) was not sufficiently potent (EC(50) = 47.2 μM), masking of the 5′-hydroxyl group seems to be an effective method for the development of anti-HCV agents. The resultant residue was purified by silica gel column chromatography (ethyl acetate/hexane, To a stirred solution of 31 (200 mg, 0.56 mmol) in dioxane (1 mL) was added 50% dimethylamine-water solution (8 mL) at room temperature, and the mixture was stirred overnight at the same temperature.	./cache/cord-334493-rt7gqiev.txt	./txt/cord-334493-rt7gqiev.txt