id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343902-hzh3cjzh	Peel, Michael	Cyclophilin inhibitors as antiviral agents	2013-08-15		.txt	text/plain	4055	184	48	Initial reports of CsA inhibiting HIV-1 surfaced in 1988, 25 although the first report specifically implicating CypA involvement in the HIV-1 life cycle was published five years later when it was reported that endogenous CypA colocalizes with the HIV-1 Gag protein in the cytoplasm, binding specifically to a Pro-rich sequence in the HIV-1 capsid domain of Gag. 26 X-ray crystallography later revealed that residues 85-93 of HIV-1 capsid bind to the active site of CypA, 27 and subsequent studies have shown that virions produced in the presence of Gag mutated in the CypA binding region, or under pressure from competitive CypA inhibitors, were less infectious than wild type virions. 36 Further support for CypA being the primary Cyp involved in HCV RNA replication include a demonstration that the catalytic PPIase activity of CypA is required for efficient HCV RNA replication, and the finding that a specific binding between CypA and NS5A is dissociable by addition of CsAbased Cyp inhibitors.	./cache/cord-343902-hzh3cjzh.txt	./txt/cord-343902-hzh3cjzh.txt