id	sid	tid	token	lemma	pos
cord-017764-h1w9gbxk	1	1	key	key	JJ
cord-017764-h1w9gbxk	1	2	:	:	:
cord-017764-h1w9gbxk	1	3	cord-017764-h1w9gbxk	cord-017764-h1w9gbxk	CD
cord-017764-h1w9gbxk	1	4	authors	author	NNS
cord-017764-h1w9gbxk	1	5	:	:	:
cord-017764-h1w9gbxk	1	6	Meanwell	Meanwell	NNP
cord-017764-h1w9gbxk	1	7	,	,	,
cord-017764-h1w9gbxk	1	8	Nicholas	Nicholas	NNP
cord-017764-h1w9gbxk	1	9	A.	a.	NN
cord-017764-h1w9gbxk	1	10	;	;	:
cord-017764-h1w9gbxk	1	11	Belema	Belema	NNP
cord-017764-h1w9gbxk	1	12	,	,	,
cord-017764-h1w9gbxk	1	13	Makonen	Makonen	NNP
cord-017764-h1w9gbxk	1	14	title	title	NN
cord-017764-h1w9gbxk	1	15	:	:	:
cord-017764-h1w9gbxk	1	16	The	the	DT
cord-017764-h1w9gbxk	1	17	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	1	18	and	and	CC
cord-017764-h1w9gbxk	1	19	Development	Development	NNP
cord-017764-h1w9gbxk	1	20	of	of	IN
cord-017764-h1w9gbxk	1	21	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	1	22	:	:	:
cord-017764-h1w9gbxk	2	1	An	an	DT
cord-017764-h1w9gbxk	2	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	2	3	of	of	IN
cord-017764-h1w9gbxk	2	4	the	the	DT
cord-017764-h1w9gbxk	2	5	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	2	6	C	C	NNP
cord-017764-h1w9gbxk	2	7	Virus	virus	NN
cord-017764-h1w9gbxk	2	8	NS5A	ns5a	CD
cord-017764-h1w9gbxk	2	9	Replication	replication	NN
cord-017764-h1w9gbxk	2	10	Complex	complex	JJ
cord-017764-h1w9gbxk	2	11	date	date	NN
cord-017764-h1w9gbxk	2	12	:	:	:
cord-017764-h1w9gbxk	2	13	2018	2018	CD
cord-017764-h1w9gbxk	2	14	-	-	HYPH
cord-017764-h1w9gbxk	2	15	06	06	CD
cord-017764-h1w9gbxk	2	16	-	-	HYPH
cord-017764-h1w9gbxk	2	17	08	08	CD
cord-017764-h1w9gbxk	2	18	journal	journal	NN
cord-017764-h1w9gbxk	2	19	:	:	:
cord-017764-h1w9gbxk	2	20	HCV	HCV	NNP
cord-017764-h1w9gbxk	2	21	:	:	:
cord-017764-h1w9gbxk	2	22	The	the	DT
cord-017764-h1w9gbxk	2	23	Journey	Journey	NNP
cord-017764-h1w9gbxk	2	24	from	from	IN
cord-017764-h1w9gbxk	2	25	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	2	26	to	to	IN
cord-017764-h1w9gbxk	2	27	a	a	DT
cord-017764-h1w9gbxk	2	28	Cure	cure	NN
cord-017764-h1w9gbxk	2	29	DOI	doi	NN
cord-017764-h1w9gbxk	2	30	:	:	:
cord-017764-h1w9gbxk	2	31	10.1007/7355_2018_47	10.1007/7355_2018_47	CD
cord-017764-h1w9gbxk	2	32	sha	sha	NN
cord-017764-h1w9gbxk	2	33	:	:	:
cord-017764-h1w9gbxk	2	34	5a17e650382dfb459b5194dea7615682e8727743	5a17e650382dfb459b5194dea7615682e8727743	NNP
cord-017764-h1w9gbxk	2	35	doc_id	doc_id	CD
cord-017764-h1w9gbxk	2	36	:	:	:
cord-017764-h1w9gbxk	3	1	17764	17764	CD
cord-017764-h1w9gbxk	3	2	cord_uid	cord_uid	NNS
cord-017764-h1w9gbxk	3	3	:	:	:
cord-017764-h1w9gbxk	3	4	h1w9gbxk	h1w9gbxk	ADD
cord-017764-h1w9gbxk	4	1	The	the	DT
cord-017764-h1w9gbxk	4	2	discovery	discovery	NN
cord-017764-h1w9gbxk	4	3	of	of	IN
cord-017764-h1w9gbxk	4	4	the	the	DT
cord-017764-h1w9gbxk	4	5	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	4	6	C	C	NNP
cord-017764-h1w9gbxk	4	7	virus	virus	NN
cord-017764-h1w9gbxk	4	8	(	(	-LRB-
cord-017764-h1w9gbxk	4	9	HCV	HCV	NNP
cord-017764-h1w9gbxk	4	10	)	)	-RRB-
cord-017764-h1w9gbxk	4	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	5	1	replication	replication	NN
cord-017764-h1w9gbxk	5	2	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	5	3	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	5	4	(	(	-LRB-
cord-017764-h1w9gbxk	5	5	1	1	CD
cord-017764-h1w9gbxk	5	6	)	)	-RRB-
cord-017764-h1w9gbxk	5	7	had	have	VBD
cord-017764-h1w9gbxk	5	8	its	-PRON-	PRP$
cord-017764-h1w9gbxk	5	9	origins	origin	NNS
cord-017764-h1w9gbxk	5	10	in	in	IN
cord-017764-h1w9gbxk	5	11	a	a	DT
cord-017764-h1w9gbxk	5	12	phenotypic	phenotypic	JJ
cord-017764-h1w9gbxk	5	13	screening	screening	NN
cord-017764-h1w9gbxk	5	14	lead	lead	NN
cord-017764-h1w9gbxk	5	15	.	.	.
cord-017764-h1w9gbxk	6	1	However	however	RB
cord-017764-h1w9gbxk	6	2	,	,	,
cord-017764-h1w9gbxk	6	3	during	during	IN
cord-017764-h1w9gbxk	6	4	the	the	DT
cord-017764-h1w9gbxk	6	5	optimization	optimization	NN
cord-017764-h1w9gbxk	6	6	campaign	campaign	NN
cord-017764-h1w9gbxk	6	7	,	,	,
cord-017764-h1w9gbxk	6	8	it	-PRON-	PRP
cord-017764-h1w9gbxk	6	9	was	be	VBD
cord-017764-h1w9gbxk	6	10	observed	observe	VBN
cord-017764-h1w9gbxk	6	11	that	that	IN
cord-017764-h1w9gbxk	6	12	some	some	DT
cord-017764-h1w9gbxk	6	13	members	member	NNS
cord-017764-h1w9gbxk	6	14	of	of	IN
cord-017764-h1w9gbxk	6	15	the	the	DT
cord-017764-h1w9gbxk	6	16	chemotype	chemotype	NN
cord-017764-h1w9gbxk	6	17	underwent	undergo	VBD
cord-017764-h1w9gbxk	6	18	a	a	DT
cord-017764-h1w9gbxk	6	19	radical	radical	JJ
cord-017764-h1w9gbxk	6	20	dimerization	dimerization	NN
cord-017764-h1w9gbxk	6	21	under	under	IN
cord-017764-h1w9gbxk	6	22	the	the	DT
cord-017764-h1w9gbxk	6	23	assay	assay	NN
cord-017764-h1w9gbxk	6	24	conditions	condition	NNS
cord-017764-h1w9gbxk	6	25	.	.	.
cord-017764-h1w9gbxk	7	1	This	this	DT
cord-017764-h1w9gbxk	7	2	redirected	redirect	VBD
cord-017764-h1w9gbxk	7	3	the	the	DT
cord-017764-h1w9gbxk	7	4	effort	effort	NN
cord-017764-h1w9gbxk	7	5	to	to	TO
cord-017764-h1w9gbxk	7	6	focus	focus	VB
cord-017764-h1w9gbxk	7	7	on	on	IN
cord-017764-h1w9gbxk	7	8	palindromic	palindromic	JJ
cord-017764-h1w9gbxk	7	9	molecules	molecule	NNS
cord-017764-h1w9gbxk	7	10	,	,	,
cord-017764-h1w9gbxk	7	11	a	a	DT
cord-017764-h1w9gbxk	7	12	species	species	NN
cord-017764-h1w9gbxk	7	13	subsequently	subsequently	RB
cord-017764-h1w9gbxk	7	14	shown	show	VBN
cord-017764-h1w9gbxk	7	15	to	to	TO
cord-017764-h1w9gbxk	7	16	complement	complement	VB
cord-017764-h1w9gbxk	7	17	the	the	DT
cord-017764-h1w9gbxk	7	18	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	7	19	nature	nature	NN
cord-017764-h1w9gbxk	7	20	of	of	IN
cord-017764-h1w9gbxk	7	21	the	the	DT
cord-017764-h1w9gbxk	7	22	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	7	23	protein	protein	NN
cord-017764-h1w9gbxk	7	24	.	.	.
cord-017764-h1w9gbxk	8	1	The	the	DT
cord-017764-h1w9gbxk	8	2	most	most	RBS
cord-017764-h1w9gbxk	8	3	challenging	challenging	JJ
cord-017764-h1w9gbxk	8	4	aspect	aspect	NN
cord-017764-h1w9gbxk	8	5	of	of	IN
cord-017764-h1w9gbxk	8	6	the	the	DT
cord-017764-h1w9gbxk	8	7	discovery	discovery	NN
cord-017764-h1w9gbxk	8	8	program	program	NN
cord-017764-h1w9gbxk	8	9	was	be	VBD
cord-017764-h1w9gbxk	8	10	extending	extend	VBG
cord-017764-h1w9gbxk	8	11	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	8	12	activity	activity	NN
cord-017764-h1w9gbxk	8	13	to	to	TO
cord-017764-h1w9gbxk	8	14	encompass	encompass	VB
cord-017764-h1w9gbxk	8	15	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	8	16	virus	virus	NN
cord-017764-h1w9gbxk	8	17	which	which	WDT
cord-017764-h1w9gbxk	8	18	was	be	VBD
cord-017764-h1w9gbxk	8	19	accomplished	accomplish	VBN
cord-017764-h1w9gbxk	8	20	only	only	RB
cord-017764-h1w9gbxk	8	21	after	after	IN
cord-017764-h1w9gbxk	8	22	the	the	DT
cord-017764-h1w9gbxk	8	23	development	development	NN
cord-017764-h1w9gbxk	8	24	of	of	IN
cord-017764-h1w9gbxk	8	25	extensive	extensive	JJ
cord-017764-h1w9gbxk	8	26	structure	structure	NN
cord-017764-h1w9gbxk	8	27	-	-	HYPH
cord-017764-h1w9gbxk	8	28	activity	activity	NN
cord-017764-h1w9gbxk	8	29	relationships	relationship	NNS
cord-017764-h1w9gbxk	8	30	.	.	.
cord-017764-h1w9gbxk	9	1	In	in	IN
cord-017764-h1w9gbxk	9	2	clinical	clinical	JJ
cord-017764-h1w9gbxk	9	3	trials	trial	NNS
cord-017764-h1w9gbxk	9	4	,	,	,
cord-017764-h1w9gbxk	9	5	oral	oral	JJ
cord-017764-h1w9gbxk	9	6	administration	administration	NN
cord-017764-h1w9gbxk	9	7	of	of	IN
cord-017764-h1w9gbxk	9	8	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	9	9	(	(	-LRB-
cord-017764-h1w9gbxk	9	10	1	1	CD
cord-017764-h1w9gbxk	9	11	)	)	-RRB-
cord-017764-h1w9gbxk	9	12	produced	produce	VBD
cord-017764-h1w9gbxk	9	13	a	a	DT
cord-017764-h1w9gbxk	9	14	profound	profound	JJ
cord-017764-h1w9gbxk	9	15	effect	effect	NN
cord-017764-h1w9gbxk	9	16	on	on	IN
cord-017764-h1w9gbxk	9	17	viral	viral	JJ
cord-017764-h1w9gbxk	9	18	load	load	NN
cord-017764-h1w9gbxk	9	19	with	with	IN
cord-017764-h1w9gbxk	9	20	onset	onset	NN
cord-017764-h1w9gbxk	9	21	that	that	WDT
cord-017764-h1w9gbxk	9	22	was	be	VBD
cord-017764-h1w9gbxk	9	23	more	more	RBR
cord-017764-h1w9gbxk	9	24	rapid	rapid	JJ
cord-017764-h1w9gbxk	9	25	than	than	IN
cord-017764-h1w9gbxk	9	26	had	have	VBD
cord-017764-h1w9gbxk	9	27	been	be	VBN
cord-017764-h1w9gbxk	9	28	seen	see	VBN
cord-017764-h1w9gbxk	9	29	previously	previously	RB
cord-017764-h1w9gbxk	9	30	with	with	IN
cord-017764-h1w9gbxk	9	31	either	either	CC
cord-017764-h1w9gbxk	9	32	NS3	ns3	RB
cord-017764-h1w9gbxk	9	33	protease	protease	NN
cord-017764-h1w9gbxk	9	34	or	or	CC
cord-017764-h1w9gbxk	9	35	NS5B	NS5B	NNP
cord-017764-h1w9gbxk	9	36	polymerase	polymerase	NN
cord-017764-h1w9gbxk	9	37	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	9	38	.	.	.
cord-017764-h1w9gbxk	10	1	A	a	DT
cord-017764-h1w9gbxk	10	2	groundbreaking	groundbreake	VBG
cord-017764-h1w9gbxk	10	3	clinical	clinical	JJ
cord-017764-h1w9gbxk	10	4	trial	trial	NN
cord-017764-h1w9gbxk	10	5	that	that	WDT
cord-017764-h1w9gbxk	10	6	combined	combine	VBN
cord-017764-h1w9gbxk	10	7	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	10	8	(	(	-LRB-
cord-017764-h1w9gbxk	10	9	1	1	CD
cord-017764-h1w9gbxk	10	10	)	)	-RRB-
cord-017764-h1w9gbxk	10	11	with	with	IN
cord-017764-h1w9gbxk	10	12	the	the	DT
cord-017764-h1w9gbxk	10	13	protease	protease	JJ
cord-017764-h1w9gbxk	10	14	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	10	15	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	10	16	(	(	-LRB-
cord-017764-h1w9gbxk	10	17	52	52	CD
cord-017764-h1w9gbxk	10	18	)	)	-RRB-
cord-017764-h1w9gbxk	10	19	established	establish	VBD
cord-017764-h1w9gbxk	10	20	that	that	IN
cord-017764-h1w9gbxk	10	21	a	a	DT
cord-017764-h1w9gbxk	10	22	chronic	chronic	JJ
cord-017764-h1w9gbxk	10	23	HCV	HCV	NNP
cord-017764-h1w9gbxk	10	24	infection	infection	NN
cord-017764-h1w9gbxk	10	25	could	could	MD
cord-017764-h1w9gbxk	10	26	be	be	VB
cord-017764-h1w9gbxk	10	27	cured	cure	VBN
cord-017764-h1w9gbxk	10	28	with	with	IN
cord-017764-h1w9gbxk	10	29	small	small	JJ
cord-017764-h1w9gbxk	10	30	molecule	molecule	NN
cord-017764-h1w9gbxk	10	31	therapy	therapy	NN
cord-017764-h1w9gbxk	10	32	in	in	IN
cord-017764-h1w9gbxk	10	33	the	the	DT
cord-017764-h1w9gbxk	10	34	absence	absence	NN
cord-017764-h1w9gbxk	10	35	of	of	IN
cord-017764-h1w9gbxk	10	36	immune	immune	JJ
cord-017764-h1w9gbxk	10	37	stimulation	stimulation	NN
cord-017764-h1w9gbxk	10	38	,	,	,
cord-017764-h1w9gbxk	10	39	setting	set	VBG
cord-017764-h1w9gbxk	10	40	the	the	DT
cord-017764-h1w9gbxk	10	41	stage	stage	NN
cord-017764-h1w9gbxk	10	42	for	for	IN
cord-017764-h1w9gbxk	10	43	approval	approval	NN
cord-017764-h1w9gbxk	10	44	of	of	IN
cord-017764-h1w9gbxk	10	45	this	this	DT
cord-017764-h1w9gbxk	10	46	regimen	regimen	NN
cord-017764-h1w9gbxk	10	47	for	for	IN
cord-017764-h1w9gbxk	10	48	the	the	DT
cord-017764-h1w9gbxk	10	49	treatment	treatment	NN
cord-017764-h1w9gbxk	10	50	of	of	IN
cord-017764-h1w9gbxk	10	51	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	10	52	-	-	HYPH
cord-017764-h1w9gbxk	10	53	infected	infect	VBN
cord-017764-h1w9gbxk	10	54	subjects	subject	NNS
cord-017764-h1w9gbxk	10	55	by	by	IN
cord-017764-h1w9gbxk	10	56	the	the	DT
cord-017764-h1w9gbxk	10	57	Japanese	japanese	JJ
cord-017764-h1w9gbxk	10	58	health	health	NN
cord-017764-h1w9gbxk	10	59	authorities	authority	NNS
cord-017764-h1w9gbxk	10	60	on	on	IN
cord-017764-h1w9gbxk	10	61	July	July	NNP
cord-017764-h1w9gbxk	10	62	4	4	CD
cord-017764-h1w9gbxk	10	63	,	,	,
cord-017764-h1w9gbxk	10	64	2014	2014	CD
cord-017764-h1w9gbxk	10	65	.	.	.
cord-017764-h1w9gbxk	11	1	The	the	DT
cord-017764-h1w9gbxk	11	2	discovery	discovery	NN
cord-017764-h1w9gbxk	11	3	of	of	IN
cord-017764-h1w9gbxk	11	4	the	the	DT
cord-017764-h1w9gbxk	11	5	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	11	6	C	C	NNP
cord-017764-h1w9gbxk	11	7	virus	virus	NN
cord-017764-h1w9gbxk	11	8	(	(	-LRB-
cord-017764-h1w9gbxk	11	9	HCV	HCV	NNP
cord-017764-h1w9gbxk	11	10	)	)	-RRB-
cord-017764-h1w9gbxk	11	11	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	11	12	5A	5a	NN
cord-017764-h1w9gbxk	11	13	(	(	-LRB-
cord-017764-h1w9gbxk	11	14	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	11	15	)	)	-RRB-
cord-017764-h1w9gbxk	11	16	replication	replication	NN
cord-017764-h1w9gbxk	11	17	complex	complex	JJ
cord-017764-h1w9gbxk	11	18	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	11	19	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	11	20	(	(	-LRB-
cord-017764-h1w9gbxk	11	21	1	1	CD
cord-017764-h1w9gbxk	11	22	)	)	-RRB-
cord-017764-h1w9gbxk	11	23	began	begin	VBD
cord-017764-h1w9gbxk	11	24	with	with	IN
cord-017764-h1w9gbxk	11	25	the	the	DT
cord-017764-h1w9gbxk	11	26	development	development	NN
cord-017764-h1w9gbxk	11	27	of	of	IN
cord-017764-h1w9gbxk	11	28	a	a	DT
cord-017764-h1w9gbxk	11	29	genotype	genotype	NN
cord-017764-h1w9gbxk	11	30	1b	1b	CD
cord-017764-h1w9gbxk	11	31	(	(	-LRB-
cord-017764-h1w9gbxk	11	32	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	11	33	)	)	-RRB-
cord-017764-h1w9gbxk	11	34	replicon	replicon	NNP
cord-017764-h1w9gbxk	11	35	that	that	WDT
cord-017764-h1w9gbxk	11	36	was	be	VBD
cord-017764-h1w9gbxk	11	37	implemented	implement	VBN
cord-017764-h1w9gbxk	11	38	as	as	IN
cord-017764-h1w9gbxk	11	39	a	a	DT
cord-017764-h1w9gbxk	11	40	phenotypic	phenotypic	JJ
cord-017764-h1w9gbxk	11	41	screen	screen	NN
cord-017764-h1w9gbxk	11	42	using	use	VBG
cord-017764-h1w9gbxk	11	43	a	a	DT
cord-017764-h1w9gbxk	11	44	design	design	NN
cord-017764-h1w9gbxk	11	45	that	that	WDT
cord-017764-h1w9gbxk	11	46	conferred	confer	VBD
cord-017764-h1w9gbxk	11	47	a	a	DT
cord-017764-h1w9gbxk	11	48	stringent	stringent	JJ
cord-017764-h1w9gbxk	11	49	triaging	triaging	NN
cord-017764-h1w9gbxk	11	50	of	of	IN
cord-017764-h1w9gbxk	11	51	hit	hit	NN
cord-017764-h1w9gbxk	11	52	molecules	molecule	NNS
cord-017764-h1w9gbxk	11	53	[	[	-LRB-
cord-017764-h1w9gbxk	11	54	1	1	CD
cord-017764-h1w9gbxk	11	55	]	]	-RRB-
cord-017764-h1w9gbxk	11	56	[	[	-LRB-
cord-017764-h1w9gbxk	11	57	2	2	CD
cord-017764-h1w9gbxk	11	58	]	]	-RRB-
cord-017764-h1w9gbxk	11	59	[	[	-LRB-
cord-017764-h1w9gbxk	11	60	3	3	CD
cord-017764-h1w9gbxk	11	61	]	]	-RRB-
cord-017764-h1w9gbxk	11	62	[	[	-LRB-
cord-017764-h1w9gbxk	11	63	4	4	CD
cord-017764-h1w9gbxk	11	64	]	]	-RRB-
cord-017764-h1w9gbxk	11	65	[	[	-LRB-
cord-017764-h1w9gbxk	11	66	5	5	CD
cord-017764-h1w9gbxk	11	67	]	]	-RRB-
cord-017764-h1w9gbxk	11	68	[	[	-LRB-
cord-017764-h1w9gbxk	11	69	6	6	CD
cord-017764-h1w9gbxk	11	70	]	]	-RRB-
cord-017764-h1w9gbxk	11	71	[	[	-LRB-
cord-017764-h1w9gbxk	11	72	7	7	CD
cord-017764-h1w9gbxk	11	73	]	]	-RRB-
cord-017764-h1w9gbxk	11	74	[	[	-LRB-
cord-017764-h1w9gbxk	11	75	8	8	CD
cord-017764-h1w9gbxk	11	76	]	]	-RRB-
cord-017764-h1w9gbxk	11	77	[	[	-LRB-
cord-017764-h1w9gbxk	11	78	9	9	CD
cord-017764-h1w9gbxk	11	79	]	]	-RRB-
cord-017764-h1w9gbxk	11	80	[	[	-LRB-
cord-017764-h1w9gbxk	11	81	10	10	CD
cord-017764-h1w9gbxk	11	82	]	]	-RRB-
cord-017764-h1w9gbxk	11	83	[	[	-LRB-
cord-017764-h1w9gbxk	11	84	11	11	CD
cord-017764-h1w9gbxk	11	85	]	]	-RRB-
cord-017764-h1w9gbxk	11	86	.	.	.
cord-017764-h1w9gbxk	12	1	This	this	DT
cord-017764-h1w9gbxk	12	2	screening	screening	NN
cord-017764-h1w9gbxk	12	3	campaign	campaign	NN
cord-017764-h1w9gbxk	12	4	was	be	VBD
cord-017764-h1w9gbxk	12	5	part	part	NN
cord-017764-h1w9gbxk	12	6	of	of	IN
cord-017764-h1w9gbxk	12	7	a	a	DT
cord-017764-h1w9gbxk	12	8	broader	broad	JJR
cord-017764-h1w9gbxk	12	9	strategy	strategy	NN
cord-017764-h1w9gbxk	12	10	that	that	WDT
cord-017764-h1w9gbxk	12	11	pursued	pursue	VBD
cord-017764-h1w9gbxk	12	12	the	the	DT
cord-017764-h1w9gbxk	12	13	identification	identification	NN
cord-017764-h1w9gbxk	12	14	of	of	IN
cord-017764-h1w9gbxk	12	15	mechanistically	mechanistically	RB
cord-017764-h1w9gbxk	12	16	orthogonal	orthogonal	JJ
cord-017764-h1w9gbxk	12	17	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	12	18	of	of	IN
cord-017764-h1w9gbxk	12	19	HCV	HCV	NNP
cord-017764-h1w9gbxk	12	20	that	that	WDT
cord-017764-h1w9gbxk	12	21	could	could	MD
cord-017764-h1w9gbxk	12	22	be	be	VB
cord-017764-h1w9gbxk	12	23	used	use	VBN
cord-017764-h1w9gbxk	12	24	in	in	IN
cord-017764-h1w9gbxk	12	25	combination	combination	NN
cord-017764-h1w9gbxk	12	26	therapy	therapy	NN
cord-017764-h1w9gbxk	12	27	,	,	,
cord-017764-h1w9gbxk	12	28	an	an	DT
cord-017764-h1w9gbxk	12	29	approach	approach	NN
cord-017764-h1w9gbxk	12	30	that	that	WDT
cord-017764-h1w9gbxk	12	31	anticipated	anticipate	VBD
cord-017764-h1w9gbxk	12	32	clinical	clinical	JJ
cord-017764-h1w9gbxk	12	33	use	use	NN
cord-017764-h1w9gbxk	12	34	of	of	IN
cord-017764-h1w9gbxk	12	35	drug	drug	NN
cord-017764-h1w9gbxk	12	36	cocktails	cocktail	NNS
cord-017764-h1w9gbxk	12	37	to	to	TO
cord-017764-h1w9gbxk	12	38	minimize	minimize	VB
cord-017764-h1w9gbxk	12	39	the	the	DT
cord-017764-h1w9gbxk	12	40	selection	selection	NN
cord-017764-h1w9gbxk	12	41	of	of	IN
cord-017764-h1w9gbxk	12	42	resistant	resistant	JJ
cord-017764-h1w9gbxk	12	43	viruses	virus	NNS
cord-017764-h1w9gbxk	12	44	.	.	.
cord-017764-h1w9gbxk	13	1	More	more	RBR
cord-017764-h1w9gbxk	13	2	specifically	specifically	RB
cord-017764-h1w9gbxk	13	3	,	,	,
cord-017764-h1w9gbxk	13	4	the	the	DT
cord-017764-h1w9gbxk	13	5	replicon	replicon	NN
cord-017764-h1w9gbxk	13	6	screen	screen	NN
cord-017764-h1w9gbxk	13	7	comprised	comprise	VBN
cord-017764-h1w9gbxk	13	8	of	of	IN
cord-017764-h1w9gbxk	13	9	simultaneously	simultaneously	RB
cord-017764-h1w9gbxk	13	10	assessing	assess	VBG
cord-017764-h1w9gbxk	13	11	the	the	DT
cord-017764-h1w9gbxk	13	12	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	13	13	activity	activity	NN
cord-017764-h1w9gbxk	13	14	of	of	IN
cord-017764-h1w9gbxk	13	15	test	test	NN
cord-017764-h1w9gbxk	13	16	molecules	molecule	NNS
cord-017764-h1w9gbxk	13	17	toward	toward	IN
cord-017764-h1w9gbxk	13	18	a	a	DT
cord-017764-h1w9gbxk	13	19	sub	sub	JJ
cord-017764-h1w9gbxk	13	20	-	-	JJ
cord-017764-h1w9gbxk	13	21	genomic	genomic	JJ
cord-017764-h1w9gbxk	13	22	HCV	HCV	NNP
cord-017764-h1w9gbxk	13	23	GT-1b	GT-1b	NNS
cord-017764-h1w9gbxk	13	24	construct	construct	VBP
cord-017764-h1w9gbxk	13	25	and	and	CC
cord-017764-h1w9gbxk	13	26	a	a	DT
cord-017764-h1w9gbxk	13	27	bovine	bovine	JJ
cord-017764-h1w9gbxk	13	28	viral	viral	JJ
cord-017764-h1w9gbxk	13	29	diarrhea	diarrhea	NN
cord-017764-h1w9gbxk	13	30	virus	virus	NN
cord-017764-h1w9gbxk	13	31	(	(	-LRB-
cord-017764-h1w9gbxk	13	32	BVDV	BVDV	NNP
cord-017764-h1w9gbxk	13	33	)	)	-RRB-
cord-017764-h1w9gbxk	13	34	replicon	replicon	NNP
cord-017764-h1w9gbxk	13	35	,	,	,
cord-017764-h1w9gbxk	13	36	both	both	DT
cord-017764-h1w9gbxk	13	37	replicating	replicate	VBG
cord-017764-h1w9gbxk	13	38	in	in	IN
cord-017764-h1w9gbxk	13	39	the	the	DT
cord-017764-h1w9gbxk	13	40	same	same	JJ
cord-017764-h1w9gbxk	13	41	human	human	JJ
cord-017764-h1w9gbxk	13	42	liver	liver	NN
cord-017764-h1w9gbxk	13	43	Huh-7	Huh-7	NNP
cord-017764-h1w9gbxk	13	44	cell	cell	NN
cord-017764-h1w9gbxk	13	45	line	line	NN
cord-017764-h1w9gbxk	13	46	background	background	NN
cord-017764-h1w9gbxk	13	47	and	and	CC
cord-017764-h1w9gbxk	13	48	seeded	seed	VBN
cord-017764-h1w9gbxk	13	49	in	in	IN
cord-017764-h1w9gbxk	13	50	the	the	DT
cord-017764-h1w9gbxk	13	51	same	same	JJ
cord-017764-h1w9gbxk	13	52	well	well	NN
cord-017764-h1w9gbxk	13	53	of	of	IN
cord-017764-h1w9gbxk	13	54	a	a	DT
cord-017764-h1w9gbxk	13	55	96-well	96-well	CD
cord-017764-h1w9gbxk	13	56	plate	plate	NN
cord-017764-h1w9gbxk	13	57	[	[	-LRB-
cord-017764-h1w9gbxk	13	58	6	6	CD
cord-017764-h1w9gbxk	13	59	]	]	-RRB-
cord-017764-h1w9gbxk	13	60	.	.	.
cord-017764-h1w9gbxk	14	1	HCV	HCV	NNP
cord-017764-h1w9gbxk	14	2	inhibition	inhibition	NN
cord-017764-h1w9gbxk	14	3	was	be	VBD
cord-017764-h1w9gbxk	14	4	determined	determine	VBN
cord-017764-h1w9gbxk	14	5	indirectly	indirectly	RB
cord-017764-h1w9gbxk	14	6	using	use	VBG
cord-017764-h1w9gbxk	14	7	a	a	DT
cord-017764-h1w9gbxk	14	8	fluorescence	fluorescence	NN
cord-017764-h1w9gbxk	14	9	resonance	resonance	NN
cord-017764-h1w9gbxk	14	10	energy	energy	NN
cord-017764-h1w9gbxk	14	11	transfer	transfer	NN
cord-017764-h1w9gbxk	14	12	(	(	-LRB-
cord-017764-h1w9gbxk	14	13	FRET)-based	fret)-based	CD
cord-017764-h1w9gbxk	14	14	assay	assay	NN
cord-017764-h1w9gbxk	14	15	that	that	WDT
cord-017764-h1w9gbxk	14	16	assessed	assess	VBN
cord-017764-h1w9gbxk	14	17	NS3	ns3	RB
cord-017764-h1w9gbxk	14	18	protease	protease	NN
cord-017764-h1w9gbxk	14	19	activity	activity	NN
cord-017764-h1w9gbxk	14	20	toward	toward	IN
cord-017764-h1w9gbxk	14	21	a	a	DT
cord-017764-h1w9gbxk	14	22	synthetic	synthetic	JJ
cord-017764-h1w9gbxk	14	23	substrate	substrate	NN
cord-017764-h1w9gbxk	14	24	incorporating	incorporate	VBG
cord-017764-h1w9gbxk	14	25	both	both	CC
cord-017764-h1w9gbxk	14	26	a	a	DT
cord-017764-h1w9gbxk	14	27	fluorescence	fluorescence	NN
cord-017764-h1w9gbxk	14	28	donor	donor	NN
cord-017764-h1w9gbxk	14	29	[	[	-LRB-
cord-017764-h1w9gbxk	14	30	(	(	-LRB-
cord-017764-h1w9gbxk	14	31	5-((2-aminoethyl)amino)naphthalene-1-sulfonic	5-((2-aminoethyl)amino)naphthalene-1-sulfonic	CD
cord-017764-h1w9gbxk	14	32	acid	acid	NN
cord-017764-h1w9gbxk	14	33	(	(	-LRB-
cord-017764-h1w9gbxk	14	34	EDANS	EDANS	NNP
cord-017764-h1w9gbxk	14	35	)	)	-RRB-
cord-017764-h1w9gbxk	14	36	]	]	-RRB-
cord-017764-h1w9gbxk	14	37	in	in	IN
cord-017764-h1w9gbxk	14	38	the	the	DT
cord-017764-h1w9gbxk	14	39	amino	amino	NN
cord-017764-h1w9gbxk	14	40	terminus	terminus	NN
cord-017764-h1w9gbxk	14	41	and	and	CC
cord-017764-h1w9gbxk	14	42	a	a	DT
cord-017764-h1w9gbxk	14	43	fluorescence	fluorescence	NN
cord-017764-h1w9gbxk	14	44	acceptor	acceptor	NN
cord-017764-h1w9gbxk	14	45	[	[	-LRB-
cord-017764-h1w9gbxk	14	46	4-((4-(dimethylamino)phenyl)azo)benzoic	4-((4-(dimethylamino)phenyl)azo)benzoic	CD
cord-017764-h1w9gbxk	14	47	acid	acid	NN
cord-017764-h1w9gbxk	14	48	,	,	,
cord-017764-h1w9gbxk	14	49	succinimidyl	succinimidyl	NNP
cord-017764-h1w9gbxk	14	50	ester	ester	NN
cord-017764-h1w9gbxk	14	51	(	(	-LRB-
cord-017764-h1w9gbxk	14	52	DABCYL	DABCYL	NNP
cord-017764-h1w9gbxk	14	53	)	)	-RRB-
cord-017764-h1w9gbxk	14	54	]	]	-RRB-
cord-017764-h1w9gbxk	14	55	at	at	IN
cord-017764-h1w9gbxk	14	56	the	the	DT
cord-017764-h1w9gbxk	14	57	carboxyl	carboxyl	NN
cord-017764-h1w9gbxk	14	58	terminus	terminus	NN
cord-017764-h1w9gbxk	14	59	.	.	.
cord-017764-h1w9gbxk	15	1	The	the	DT
cord-017764-h1w9gbxk	15	2	BVDV	BVDV	NNP
cord-017764-h1w9gbxk	15	3	replicon	replicon	NN
cord-017764-h1w9gbxk	15	4	incorporated	incorporate	VBD
cord-017764-h1w9gbxk	15	5	a	a	DT
cord-017764-h1w9gbxk	15	6	firefly	firefly	NN
cord-017764-h1w9gbxk	15	7	luciferase	luciferase	NN
cord-017764-h1w9gbxk	15	8	reporter	reporter	NN
cord-017764-h1w9gbxk	15	9	gene	gene	NN
cord-017764-h1w9gbxk	15	10	that	that	WDT
cord-017764-h1w9gbxk	15	11	provided	provide	VBD
cord-017764-h1w9gbxk	15	12	an	an	DT
cord-017764-h1w9gbxk	15	13	orthogonal	orthogonal	JJ
cord-017764-h1w9gbxk	15	14	readout	readout	NN
cord-017764-h1w9gbxk	15	15	of	of	IN
cord-017764-h1w9gbxk	15	16	replication	replication	NN
cord-017764-h1w9gbxk	15	17	activity	activity	NN
cord-017764-h1w9gbxk	15	18	based	base	VBN
cord-017764-h1w9gbxk	15	19	on	on	IN
cord-017764-h1w9gbxk	15	20	the	the	DT
cord-017764-h1w9gbxk	15	21	emission	emission	NN
cord-017764-h1w9gbxk	15	22	of	of	IN
cord-017764-h1w9gbxk	15	23	light	light	NN
cord-017764-h1w9gbxk	15	24	,	,	,
cord-017764-h1w9gbxk	15	25	reflecting	reflect	VBG
cord-017764-h1w9gbxk	15	26	the	the	DT
cord-017764-h1w9gbxk	15	27	amount	amount	NN
cord-017764-h1w9gbxk	15	28	of	of	IN
cord-017764-h1w9gbxk	15	29	enzyme	enzyme	NN
cord-017764-h1w9gbxk	15	30	present	present	NN
cord-017764-h1w9gbxk	15	31	after	after	IN
cord-017764-h1w9gbxk	15	32	adding	add	VBG
cord-017764-h1w9gbxk	15	33	a	a	DT
cord-017764-h1w9gbxk	15	34	substrate	substrate	NN
cord-017764-h1w9gbxk	15	35	.	.	.
cord-017764-h1w9gbxk	16	1	The	the	DT
cord-017764-h1w9gbxk	16	2	third	third	JJ
cord-017764-h1w9gbxk	16	3	piece	piece	NN
cord-017764-h1w9gbxk	16	4	of	of	IN
cord-017764-h1w9gbxk	16	5	information	information	NN
cord-017764-h1w9gbxk	16	6	harvested	harvest	VBN
cord-017764-h1w9gbxk	16	7	from	from	IN
cord-017764-h1w9gbxk	16	8	the	the	DT
cord-017764-h1w9gbxk	16	9	assay	assay	NN
cord-017764-h1w9gbxk	16	10	,	,	,
cord-017764-h1w9gbxk	16	11	which	which	WDT
cord-017764-h1w9gbxk	16	12	was	be	VBD
cord-017764-h1w9gbxk	16	13	also	also	RB
cord-017764-h1w9gbxk	16	14	the	the	DT
cord-017764-h1w9gbxk	16	15	first	first	JJ
cord-017764-h1w9gbxk	16	16	experimental	experimental	JJ
cord-017764-h1w9gbxk	16	17	data	datum	NNS
cord-017764-h1w9gbxk	16	18	obtained	obtain	VBN
cord-017764-h1w9gbxk	16	19	,	,	,
cord-017764-h1w9gbxk	16	20	was	be	VBD
cord-017764-h1w9gbxk	16	21	AlamarBlue	AlamarBlue	NNP
cord-017764-h1w9gbxk	16	22	cell	cell	NN
cord-017764-h1w9gbxk	16	23	viability	viability	NN
cord-017764-h1w9gbxk	16	24	staining	staining	NN
cord-017764-h1w9gbxk	16	25	which	which	WDT
cord-017764-h1w9gbxk	16	26	assessed	assess	VBD
cord-017764-h1w9gbxk	16	27	mitochondrial	mitochondrial	NN
cord-017764-h1w9gbxk	16	28	function	function	NN
cord-017764-h1w9gbxk	16	29	,	,	,
cord-017764-h1w9gbxk	16	30	providing	provide	VBG
cord-017764-h1w9gbxk	16	31	an	an	DT
cord-017764-h1w9gbxk	16	32	indication	indication	NN
cord-017764-h1w9gbxk	16	33	of	of	IN
cord-017764-h1w9gbxk	16	34	the	the	DT
cord-017764-h1w9gbxk	16	35	cytotoxicity	cytotoxicity	NN
cord-017764-h1w9gbxk	16	36	of	of	IN
cord-017764-h1w9gbxk	16	37	test	test	NN
cord-017764-h1w9gbxk	16	38	compounds	compound	NNS
cord-017764-h1w9gbxk	16	39	.	.	.
cord-017764-h1w9gbxk	17	1	This	this	DT
cord-017764-h1w9gbxk	17	2	assay	assay	NN
cord-017764-h1w9gbxk	17	3	configuration	configuration	NN
cord-017764-h1w9gbxk	17	4	was	be	VBD
cord-017764-h1w9gbxk	17	5	used	use	VBN
cord-017764-h1w9gbxk	17	6	to	to	TO
cord-017764-h1w9gbxk	17	7	interrogate	interrogate	VB
cord-017764-h1w9gbxk	17	8	a	a	DT
cord-017764-h1w9gbxk	17	9	representative	representative	JJ
cord-017764-h1w9gbxk	17	10	selection	selection	NN
cord-017764-h1w9gbxk	17	11	of	of	IN
cord-017764-h1w9gbxk	17	12	the	the	DT
cord-017764-h1w9gbxk	17	13	Bristol	Bristol	NNP
cord-017764-h1w9gbxk	17	14	-	-	HYPH
cord-017764-h1w9gbxk	17	15	Myers	Myers	NNP
cord-017764-h1w9gbxk	17	16	Squibb	Squibb	NNP
cord-017764-h1w9gbxk	17	17	proprietary	proprietary	JJ
cord-017764-h1w9gbxk	17	18	compound	compound	NN
cord-017764-h1w9gbxk	17	19	collection	collection	NN
cord-017764-h1w9gbxk	17	20	and	and	CC
cord-017764-h1w9gbxk	17	21	identified	identify	VBD
cord-017764-h1w9gbxk	17	22	the	the	DT
cord-017764-h1w9gbxk	17	23	iminothiazolidinone	iminothiazolidinone	NN
cord-017764-h1w9gbxk	17	24	2	2	CD
cord-017764-h1w9gbxk	17	25	as	as	IN
cord-017764-h1w9gbxk	17	26	hit	hit	VBN
cord-017764-h1w9gbxk	17	27	that	that	WDT
cord-017764-h1w9gbxk	17	28	met	meet	VBD
cord-017764-h1w9gbxk	17	29	the	the	DT
cord-017764-h1w9gbxk	17	30	criteria	criterion	NNS
cord-017764-h1w9gbxk	17	31	of	of	IN
cord-017764-h1w9gbxk	17	32	exhibiting	exhibit	VBG
cord-017764-h1w9gbxk	17	33	activity	activity	NN
cord-017764-h1w9gbxk	17	34	toward	toward	IN
cord-017764-h1w9gbxk	17	35	the	the	DT
cord-017764-h1w9gbxk	17	36	HCV	HCV	NNP
cord-017764-h1w9gbxk	17	37	replicon	replicon	NN
cord-017764-h1w9gbxk	17	38	at	at	IN
cord-017764-h1w9gbxk	17	39	concentrations	concentration	NNS
cord-017764-h1w9gbxk	17	40	at	at	IN
cord-017764-h1w9gbxk	17	41	least	least	JJS
cord-017764-h1w9gbxk	17	42	tenfold	tenfold	RB
cord-017764-h1w9gbxk	17	43	lower	lower	RBR
cord-017764-h1w9gbxk	17	44	than	than	IN
cord-017764-h1w9gbxk	17	45	either	either	CC
cord-017764-h1w9gbxk	17	46	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	17	47	activity	activity	NN
cord-017764-h1w9gbxk	17	48	toward	toward	IN
cord-017764-h1w9gbxk	17	49	the	the	DT
cord-017764-h1w9gbxk	17	50	BVDV	BVDV	NNP
cord-017764-h1w9gbxk	17	51	replicon	replicon	NN
cord-017764-h1w9gbxk	17	52	or	or	CC
cord-017764-h1w9gbxk	17	53	cytotoxicity	cytotoxicity	NN
cord-017764-h1w9gbxk	17	54	[	[	-LRB-
cord-017764-h1w9gbxk	17	55	12	12	CD
cord-017764-h1w9gbxk	17	56	]	]	-RRB-
cord-017764-h1w9gbxk	17	57	.	.	.
cord-017764-h1w9gbxk	18	1	The	the	DT
cord-017764-h1w9gbxk	18	2	specific	specific	JJ
cord-017764-h1w9gbxk	18	3	details	detail	NNS
cord-017764-h1w9gbxk	18	4	of	of	IN
cord-017764-h1w9gbxk	18	5	the	the	DT
cord-017764-h1w9gbxk	18	6	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	18	7	profile	profile	NN
cord-017764-h1w9gbxk	18	8	of	of	IN
cord-017764-h1w9gbxk	18	9	2	2	CD
cord-017764-h1w9gbxk	18	10	in	in	IN
cord-017764-h1w9gbxk	18	11	the	the	DT
cord-017764-h1w9gbxk	18	12	screening	screening	NN
cord-017764-h1w9gbxk	18	13	assays	assay	NNS
cord-017764-h1w9gbxk	18	14	and	and	CC
cord-017764-h1w9gbxk	18	15	toward	toward	IN
cord-017764-h1w9gbxk	18	16	a	a	DT
cord-017764-h1w9gbxk	18	17	panel	panel	NN
cord-017764-h1w9gbxk	18	18	of	of	IN
cord-017764-h1w9gbxk	18	19	viruses	virus	NNS
cord-017764-h1w9gbxk	18	20	are	be	VBP
cord-017764-h1w9gbxk	18	21	summarized	summarize	VBN
cord-017764-h1w9gbxk	18	22	in	in	IN
cord-017764-h1w9gbxk	18	23	Table	Table	NNP
cord-017764-h1w9gbxk	18	24	1	1	CD
cord-017764-h1w9gbxk	18	25	.	.	.
cord-017764-h1w9gbxk	19	1	Compound	compound	NN
cord-017764-h1w9gbxk	19	2	2	2	CD
cord-017764-h1w9gbxk	19	3	had	have	VBD
cord-017764-h1w9gbxk	19	4	an	an	DT
cord-017764-h1w9gbxk	19	5	interesting	interesting	JJ
cord-017764-h1w9gbxk	19	6	background	background	NN
cord-017764-h1w9gbxk	19	7	since	since	IN
cord-017764-h1w9gbxk	19	8	it	-PRON-	PRP
cord-017764-h1w9gbxk	19	9	had	have	VBD
cord-017764-h1w9gbxk	19	10	its	-PRON-	PRP$
cord-017764-h1w9gbxk	19	11	origin	origin	NN
cord-017764-h1w9gbxk	19	12	in	in	IN
cord-017764-h1w9gbxk	19	13	a	a	DT
cord-017764-h1w9gbxk	19	14	prospective	prospective	JJ
cord-017764-h1w9gbxk	19	15	library	library	NN
cord-017764-h1w9gbxk	19	16	that	that	WDT
cord-017764-h1w9gbxk	19	17	had	have	VBD
cord-017764-h1w9gbxk	19	18	been	be	VBN
cord-017764-h1w9gbxk	19	19	prepared	prepare	VBN
cord-017764-h1w9gbxk	19	20	as	as	IN
cord-017764-h1w9gbxk	19	21	part	part	NN
cord-017764-h1w9gbxk	19	22	of	of	IN
cord-017764-h1w9gbxk	19	23	a	a	DT
cord-017764-h1w9gbxk	19	24	campaign	campaign	NN
cord-017764-h1w9gbxk	19	25	to	to	TO
cord-017764-h1w9gbxk	19	26	embellish	embellish	VB
cord-017764-h1w9gbxk	19	27	the	the	DT
cord-017764-h1w9gbxk	19	28	Bristol	Bristol	NNP
cord-017764-h1w9gbxk	19	29	-	-	HYPH
cord-017764-h1w9gbxk	19	30	Myers	Myers	NNP
cord-017764-h1w9gbxk	19	31	Squibb	Squibb	NNP
cord-017764-h1w9gbxk	19	32	proprietary	proprietary	JJ
cord-017764-h1w9gbxk	19	33	compound	compound	NN
cord-017764-h1w9gbxk	19	34	collection	collection	NN
cord-017764-h1w9gbxk	19	35	.	.	.
cord-017764-h1w9gbxk	20	1	A	a	DT
cord-017764-h1w9gbxk	20	2	notable	notable	JJ
cord-017764-h1w9gbxk	20	3	structural	structural	JJ
cord-017764-h1w9gbxk	20	4	feature	feature	NN
cord-017764-h1w9gbxk	20	5	of	of	IN
cord-017764-h1w9gbxk	20	6	2	2	CD
cord-017764-h1w9gbxk	20	7	is	be	VBZ
cord-017764-h1w9gbxk	20	8	that	that	IN
cord-017764-h1w9gbxk	20	9	it	-PRON-	PRP
cord-017764-h1w9gbxk	20	10	had	have	VBD
cord-017764-h1w9gbxk	20	11	been	be	VBN
cord-017764-h1w9gbxk	20	12	designed	design	VBN
cord-017764-h1w9gbxk	20	13	to	to	TO
cord-017764-h1w9gbxk	20	14	include	include	VB
cord-017764-h1w9gbxk	20	15	a	a	DT
cord-017764-h1w9gbxk	20	16	phenyl	phenyl	NN
cord-017764-h1w9gbxk	20	17	substituent	substituent	NN
cord-017764-h1w9gbxk	20	18	at	at	IN
cord-017764-h1w9gbxk	20	19	C-5	C-5	NNP
cord-017764-h1w9gbxk	20	20	,	,	,
cord-017764-h1w9gbxk	20	21	unusual	unusual	JJ
cord-017764-h1w9gbxk	20	22	since	since	IN
cord-017764-h1w9gbxk	20	23	C-5	C-5	NNP
cord-017764-h1w9gbxk	20	24	benzylidene	benzylidene	NNP
cord-017764-h1w9gbxk	20	25	derivatives	derivative	NNS
cord-017764-h1w9gbxk	20	26	are	be	VBP
cord-017764-h1w9gbxk	20	27	far	far	RB
cord-017764-h1w9gbxk	20	28	more	more	RBR
cord-017764-h1w9gbxk	20	29	prevalent	prevalent	JJ
cord-017764-h1w9gbxk	20	30	in	in	IN
cord-017764-h1w9gbxk	20	31	the	the	DT
cord-017764-h1w9gbxk	20	32	literature	literature	NN
cord-017764-h1w9gbxk	20	33	,	,	,
cord-017764-h1w9gbxk	20	34	a	a	DT
cord-017764-h1w9gbxk	20	35	function	function	NN
cord-017764-h1w9gbxk	20	36	of	of	IN
cord-017764-h1w9gbxk	20	37	convenient	convenient	JJ
cord-017764-h1w9gbxk	20	38	access	access	NN
cord-017764-h1w9gbxk	20	39	by	by	IN
cord-017764-h1w9gbxk	20	40	way	way	NN
cord-017764-h1w9gbxk	20	41	of	of	IN
cord-017764-h1w9gbxk	20	42	a	a	DT
cord-017764-h1w9gbxk	20	43	Knoevenagel	Knoevenagel	NNP
cord-017764-h1w9gbxk	20	44	condensation	condensation	NN
cord-017764-h1w9gbxk	20	45	reaction	reaction	NN
cord-017764-h1w9gbxk	20	46	between	between	IN
cord-017764-h1w9gbxk	20	47	a	a	DT
cord-017764-h1w9gbxk	20	48	C-5	C-5	NNP
cord-017764-h1w9gbxk	20	49	unsubstituted	unsubstitute	VBN
cord-017764-h1w9gbxk	20	50	iminothiazolidinone	iminothiazolidinone	NN
cord-017764-h1w9gbxk	20	51	and	and	CC
cord-017764-h1w9gbxk	20	52	an	an	DT
cord-017764-h1w9gbxk	20	53	aldehyde	aldehyde	NN
cord-017764-h1w9gbxk	20	54	[	[	-LRB-
cord-017764-h1w9gbxk	20	55	13	13	CD
cord-017764-h1w9gbxk	20	56	,	,	,
cord-017764-h1w9gbxk	20	57	14	14	CD
cord-017764-h1w9gbxk	20	58	]	]	-RRB-
cord-017764-h1w9gbxk	20	59	.	.	.
cord-017764-h1w9gbxk	21	1	The	the	DT
cord-017764-h1w9gbxk	21	2	data	datum	NNS
cord-017764-h1w9gbxk	21	3	accumulated	accumulate	VBN
cord-017764-h1w9gbxk	21	4	for	for	IN
cord-017764-h1w9gbxk	21	5	2	2	CD
cord-017764-h1w9gbxk	21	6	that	that	WDT
cord-017764-h1w9gbxk	21	7	are	be	VBP
cord-017764-h1w9gbxk	21	8	compiled	compile	VBN
cord-017764-h1w9gbxk	21	9	in	in	IN
cord-017764-h1w9gbxk	21	10	Table	Table	NNP
cord-017764-h1w9gbxk	21	11	1	1	CD
cord-017764-h1w9gbxk	21	12	revealed	reveal	VBD
cord-017764-h1w9gbxk	21	13	a	a	DT
cord-017764-h1w9gbxk	21	14	profile	profile	NN
cord-017764-h1w9gbxk	21	15	of	of	IN
cord-017764-h1w9gbxk	21	16	significant	significant	JJ
cord-017764-h1w9gbxk	21	17	and	and	CC
cord-017764-h1w9gbxk	21	18	selective	selective	JJ
cord-017764-h1w9gbxk	21	19	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	21	20	potency	potency	NN
cord-017764-h1w9gbxk	21	21	toward	toward	IN
cord-017764-h1w9gbxk	21	22	the	the	DT
cord-017764-h1w9gbxk	21	23	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	21	24	HCV	HCV	NNP
cord-017764-h1w9gbxk	21	25	replicon	replicon	NN
cord-017764-h1w9gbxk	21	26	with	with	IN
cord-017764-h1w9gbxk	21	27	an	an	DT
cord-017764-h1w9gbxk	21	28	EC	EC	NNP
cord-017764-h1w9gbxk	21	29	50	50	CD
cord-017764-h1w9gbxk	21	30	value	value	NN
cord-017764-h1w9gbxk	21	31	of	of	IN
cord-017764-h1w9gbxk	21	32	570	570	CD
cord-017764-h1w9gbxk	21	33	nM	nm	NN
cord-017764-h1w9gbxk	21	34	,	,	,
cord-017764-h1w9gbxk	21	35	a	a	DT
cord-017764-h1w9gbxk	21	36	finding	finding	NN
cord-017764-h1w9gbxk	21	37	that	that	WDT
cord-017764-h1w9gbxk	21	38	encouraged	encourage	VBD
cord-017764-h1w9gbxk	21	39	further	further	JJ
cord-017764-h1w9gbxk	21	40	study	study	NN
cord-017764-h1w9gbxk	21	41	of	of	IN
cord-017764-h1w9gbxk	21	42	the	the	DT
cord-017764-h1w9gbxk	21	43	chemotype	chemotype	NNPS
cord-017764-h1w9gbxk	21	44	[	[	-LRB-
cord-017764-h1w9gbxk	21	45	15	15	CD
cord-017764-h1w9gbxk	21	46	]	]	-RRB-
cord-017764-h1w9gbxk	21	47	.	.	.
cord-017764-h1w9gbxk	22	1	Adding	add	VBG
cord-017764-h1w9gbxk	22	2	to	to	IN
cord-017764-h1w9gbxk	22	3	the	the	DT
cord-017764-h1w9gbxk	22	4	intrigue	intrigue	NN
cord-017764-h1w9gbxk	22	5	with	with	IN
cord-017764-h1w9gbxk	22	6	2	2	CD
cord-017764-h1w9gbxk	22	7	as	as	IN
cord-017764-h1w9gbxk	22	8	a	a	DT
cord-017764-h1w9gbxk	22	9	lead	lead	JJ
cord-017764-h1w9gbxk	22	10	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	22	11	was	be	VBD
cord-017764-h1w9gbxk	22	12	the	the	DT
cord-017764-h1w9gbxk	22	13	generation	generation	NN
cord-017764-h1w9gbxk	22	14	and	and	CC
cord-017764-h1w9gbxk	22	15	validation	validation	NN
cord-017764-h1w9gbxk	22	16	of	of	IN
cord-017764-h1w9gbxk	22	17	resistant	resistant	JJ
cord-017764-h1w9gbxk	22	18	mutants	mutant	NNS
cord-017764-h1w9gbxk	22	19	arising	arise	VBG
cord-017764-h1w9gbxk	22	20	in	in	IN
cord-017764-h1w9gbxk	22	21	the	the	DT
cord-017764-h1w9gbxk	22	22	replicon	replicon	NN
cord-017764-h1w9gbxk	22	23	in	in	IN
cord-017764-h1w9gbxk	22	24	response	response	NN
cord-017764-h1w9gbxk	22	25	to	to	IN
cord-017764-h1w9gbxk	22	26	selective	selective	JJ
cord-017764-h1w9gbxk	22	27	pressure	pressure	NN
cord-017764-h1w9gbxk	22	28	that	that	WDT
cord-017764-h1w9gbxk	22	29	mapped	map	VBD
cord-017764-h1w9gbxk	22	30	to	to	IN
cord-017764-h1w9gbxk	22	31	the	the	DT
cord-017764-h1w9gbxk	22	32	amino	amino	NN
cord-017764-h1w9gbxk	22	33	terminus	terminus	NN
cord-017764-h1w9gbxk	22	34	of	of	IN
cord-017764-h1w9gbxk	22	35	the	the	DT
cord-017764-h1w9gbxk	22	36	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	22	37	protein	protein	NN
cord-017764-h1w9gbxk	22	38	,	,	,
cord-017764-h1w9gbxk	22	39	specifically	specifically	RB
cord-017764-h1w9gbxk	22	40	a	a	DT
cord-017764-h1w9gbxk	22	41	Tyr98His	tyr98his	NN
cord-017764-h1w9gbxk	22	42	and	and	CC
cord-017764-h1w9gbxk	22	43	a	a	DT
cord-017764-h1w9gbxk	22	44	Leu31Val	Leu31Val	NNP
cord-017764-h1w9gbxk	22	45	/	/	SYM
cord-017764-h1w9gbxk	22	46	Gln54Leu	gln54leu	NN
cord-017764-h1w9gbxk	22	47	combination	combination	NN
cord-017764-h1w9gbxk	22	48	[	[	-LRB-
cord-017764-h1w9gbxk	22	49	12	12	CD
cord-017764-h1w9gbxk	22	50	]	]	-RRB-
cord-017764-h1w9gbxk	22	51	.	.	.
cord-017764-h1w9gbxk	23	1	At	at	IN
cord-017764-h1w9gbxk	23	2	the	the	DT
cord-017764-h1w9gbxk	23	3	time	time	NN
cord-017764-h1w9gbxk	23	4	of	of	IN
cord-017764-h1w9gbxk	23	5	this	this	DT
cord-017764-h1w9gbxk	23	6	discovery	discovery	NN
cord-017764-h1w9gbxk	23	7	,	,	,
cord-017764-h1w9gbxk	23	8	little	little	JJ
cord-017764-h1w9gbxk	23	9	was	be	VBD
cord-017764-h1w9gbxk	23	10	known	know	VBN
cord-017764-h1w9gbxk	23	11	about	about	IN
cord-017764-h1w9gbxk	23	12	the	the	DT
cord-017764-h1w9gbxk	23	13	specific	specific	JJ
cord-017764-h1w9gbxk	23	14	functions	function	NNS
cord-017764-h1w9gbxk	23	15	of	of	IN
cord-017764-h1w9gbxk	23	16	the	the	DT
cord-017764-h1w9gbxk	23	17	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	23	18	protein	protein	NN
cord-017764-h1w9gbxk	23	19	in	in	IN
cord-017764-h1w9gbxk	23	20	viral	viral	JJ
cord-017764-h1w9gbxk	23	21	replication	replication	NN
cord-017764-h1w9gbxk	23	22	although	although	IN
cord-017764-h1w9gbxk	23	23	,	,	,
cord-017764-h1w9gbxk	23	24	perhaps	perhaps	RB
cord-017764-h1w9gbxk	23	25	not	not	RB
cord-017764-h1w9gbxk	23	26	surprisingly	surprisingly	RB
cord-017764-h1w9gbxk	23	27	for	for	IN
cord-017764-h1w9gbxk	23	28	such	such	PDT
cord-017764-h1w9gbxk	23	29	a	a	DT
cord-017764-h1w9gbxk	23	30	small	small	JJ
cord-017764-h1w9gbxk	23	31	virus	virus	NN
cord-017764-h1w9gbxk	23	32	,	,	,
cord-017764-h1w9gbxk	23	33	it	-PRON-	PRP
cord-017764-h1w9gbxk	23	34	was	be	VBD
cord-017764-h1w9gbxk	23	35	known	know	VBN
cord-017764-h1w9gbxk	23	36	to	to	TO
cord-017764-h1w9gbxk	23	37	be	be	VB
cord-017764-h1w9gbxk	23	38	an	an	DT
cord-017764-h1w9gbxk	23	39	essential	essential	JJ
cord-017764-h1w9gbxk	23	40	protein	protein	NN
cord-017764-h1w9gbxk	23	41	[	[	-LRB-
cord-017764-h1w9gbxk	23	42	16	16	CD
cord-017764-h1w9gbxk	23	43	]	]	-RRB-
cord-017764-h1w9gbxk	23	44	[	[	-LRB-
cord-017764-h1w9gbxk	23	45	17	17	CD
cord-017764-h1w9gbxk	23	46	]	]	-RRB-
cord-017764-h1w9gbxk	23	47	[	[	-LRB-
cord-017764-h1w9gbxk	23	48	18	18	CD
cord-017764-h1w9gbxk	23	49	]	]	-RRB-
cord-017764-h1w9gbxk	23	50	[	[	-LRB-
cord-017764-h1w9gbxk	23	51	19	19	CD
cord-017764-h1w9gbxk	23	52	]	]	-RRB-
cord-017764-h1w9gbxk	23	53	[	[	-LRB-
cord-017764-h1w9gbxk	23	54	20	20	CD
cord-017764-h1w9gbxk	23	55	]	]	-RRB-
cord-017764-h1w9gbxk	23	56	.	.	.
cord-017764-h1w9gbxk	24	1	The	the	DT
cord-017764-h1w9gbxk	24	2	Z	z	NN
cord-017764-h1w9gbxk	24	3	-	-	HYPH
cord-017764-h1w9gbxk	24	4	configuration	configuration	NN
cord-017764-h1w9gbxk	24	5	of	of	IN
cord-017764-h1w9gbxk	24	6	the	the	DT
cord-017764-h1w9gbxk	24	7	2-arylimino	2-arylimino	CD
cord-017764-h1w9gbxk	24	8	moiety	moiety	NN
cord-017764-h1w9gbxk	24	9	of	of	IN
cord-017764-h1w9gbxk	24	10	2	2	CD
cord-017764-h1w9gbxk	24	11	was	be	VBD
cord-017764-h1w9gbxk	24	12	assigned	assign	VBN
cord-017764-h1w9gbxk	24	13	based	base	VBN
cord-017764-h1w9gbxk	24	14	on	on	IN
cord-017764-h1w9gbxk	24	15	prior	prior	JJ
cord-017764-h1w9gbxk	24	16	studies	study	NNS
cord-017764-h1w9gbxk	24	17	which	which	WDT
cord-017764-h1w9gbxk	24	18	indicated	indicate	VBD
cord-017764-h1w9gbxk	24	19	that	that	IN
cord-017764-h1w9gbxk	24	20	this	this	DT
cord-017764-h1w9gbxk	24	21	topology	topology	NN
cord-017764-h1w9gbxk	24	22	minimized	minimize	VBD
cord-017764-h1w9gbxk	24	23	steric	steric	JJ
cord-017764-h1w9gbxk	24	24	effects	effect	NNS
cord-017764-h1w9gbxk	24	25	.	.	.
cord-017764-h1w9gbxk	25	1	However	however	RB
cord-017764-h1w9gbxk	25	2	,	,	,
cord-017764-h1w9gbxk	25	3	attempts	attempt	VBZ
cord-017764-h1w9gbxk	25	4	to	to	TO
cord-017764-h1w9gbxk	25	5	separate	separate	VB
cord-017764-h1w9gbxk	25	6	the	the	DT
cord-017764-h1w9gbxk	25	7	individual	individual	JJ
cord-017764-h1w9gbxk	25	8	stereoisomers	stereoisomer	NNS
cord-017764-h1w9gbxk	25	9	at	at	IN
cord-017764-h1w9gbxk	25	10	C-5	C-5	NNP
cord-017764-h1w9gbxk	25	11	were	be	VBD
cord-017764-h1w9gbxk	25	12	thwarted	thwart	VBN
cord-017764-h1w9gbxk	25	13	by	by	IN
cord-017764-h1w9gbxk	25	14	facile	facile	JJ
cord-017764-h1w9gbxk	25	15	racemization	racemization	NN
cord-017764-h1w9gbxk	25	16	of	of	IN
cord-017764-h1w9gbxk	25	17	the	the	DT
cord-017764-h1w9gbxk	25	18	benzylic	benzylic	JJ
cord-017764-h1w9gbxk	25	19	center	center	NN
cord-017764-h1w9gbxk	25	20	after	after	IN
cord-017764-h1w9gbxk	25	21	chiral	chiral	JJ
cord-017764-h1w9gbxk	25	22	chromatographic	chromatographic	JJ
cord-017764-h1w9gbxk	25	23	separation	separation	NN
cord-017764-h1w9gbxk	25	24	[	[	-LRB-
cord-017764-h1w9gbxk	25	25	15	15	CD
cord-017764-h1w9gbxk	25	26	,	,	,
cord-017764-h1w9gbxk	25	27	21	21	CD
cord-017764-h1w9gbxk	25	28	]	]	-RRB-
cord-017764-h1w9gbxk	25	29	.	.	.
cord-017764-h1w9gbxk	26	1	Seminal	seminal	JJ
cord-017764-h1w9gbxk	26	2	insights	insight	NNS
cord-017764-h1w9gbxk	26	3	into	into	IN
cord-017764-h1w9gbxk	26	4	structure	structure	NN
cord-017764-h1w9gbxk	26	5	-	-	HYPH
cord-017764-h1w9gbxk	26	6	activity	activity	NN
cord-017764-h1w9gbxk	26	7	relationships	relationship	NNS
cord-017764-h1w9gbxk	26	8	(	(	-LRB-
cord-017764-h1w9gbxk	26	9	SARs	SARs	NNP
cord-017764-h1w9gbxk	26	10	)	)	-RRB-
cord-017764-h1w9gbxk	26	11	were	be	VBD
cord-017764-h1w9gbxk	26	12	gleaned	glean	VBN
cord-017764-h1w9gbxk	26	13	from	from	IN
cord-017764-h1w9gbxk	26	14	a	a	DT
cord-017764-h1w9gbxk	26	15	survey	survey	NN
cord-017764-h1w9gbxk	26	16	that	that	WDT
cord-017764-h1w9gbxk	26	17	explored	explore	VBD
cord-017764-h1w9gbxk	26	18	variation	variation	NN
cord-017764-h1w9gbxk	26	19	of	of	IN
cord-017764-h1w9gbxk	26	20	the	the	DT
cord-017764-h1w9gbxk	26	21	three	three	CD
cord-017764-h1w9gbxk	26	22	major	major	JJ
cord-017764-h1w9gbxk	26	23	peripheral	peripheral	JJ
cord-017764-h1w9gbxk	26	24	elements	element	NNS
cord-017764-h1w9gbxk	26	25	of	of	IN
cord-017764-h1w9gbxk	26	26	the	the	DT
cord-017764-h1w9gbxk	26	27	moleculethe	moleculethe	NNP
cord-017764-h1w9gbxk	26	28	furanylmethyl	furanylmethyl	NN
cord-017764-h1w9gbxk	26	29	substituent	substituent	NNP
cord-017764-h1w9gbxk	26	30	,	,	,
cord-017764-h1w9gbxk	26	31	the	the	DT
cord-017764-h1w9gbxk	26	32	arylimino	arylimino	NN
cord-017764-h1w9gbxk	26	33	moiety	moiety	NN
cord-017764-h1w9gbxk	26	34	,	,	,
cord-017764-h1w9gbxk	26	35	and	and	CC
cord-017764-h1w9gbxk	26	36	the	the	DT
cord-017764-h1w9gbxk	26	37	amino	amino	NN
cord-017764-h1w9gbxk	26	38	acid	acid	NN
cord-017764-h1w9gbxk	26	39	amide	amide	NN
cord-017764-h1w9gbxk	26	40	.	.	.
cord-017764-h1w9gbxk	27	1	Changes	change	NNS
cord-017764-h1w9gbxk	27	2	to	to	IN
cord-017764-h1w9gbxk	27	3	both	both	CC
cord-017764-h1w9gbxk	27	4	the	the	DT
cord-017764-h1w9gbxk	27	5	furanylmethyl	furanylmethyl	NN
cord-017764-h1w9gbxk	27	6	and	and	CC
cord-017764-h1w9gbxk	27	7	arylimino	arylimino	NNP
cord-017764-h1w9gbxk	27	8	moieties	moiety	NNS
cord-017764-h1w9gbxk	27	9	in	in	IN
cord-017764-h1w9gbxk	27	10	the	the	DT
cord-017764-h1w9gbxk	27	11	context	context	NN
cord-017764-h1w9gbxk	27	12	of	of	IN
cord-017764-h1w9gbxk	27	13	the	the	DT
cord-017764-h1w9gbxk	27	14	Cbz	Cbz	NNP
cord-017764-h1w9gbxk	27	15	-	-	HYPH
cord-017764-h1w9gbxk	27	16	alanine	alanine	NN
cord-017764-h1w9gbxk	27	17	amide	amide	NN
cord-017764-h1w9gbxk	27	18	were	be	VBD
cord-017764-h1w9gbxk	27	19	found	find	VBN
cord-017764-h1w9gbxk	27	20	to	to	TO
cord-017764-h1w9gbxk	27	21	influence	influence	VB
cord-017764-h1w9gbxk	27	22	potency	potency	NN
cord-017764-h1w9gbxk	27	23	,	,	,
cord-017764-h1w9gbxk	27	24	with	with	IN
cord-017764-h1w9gbxk	27	25	compounds	compound	NNS
cord-017764-h1w9gbxk	27	26	incorporating	incorporate	VBG
cord-017764-h1w9gbxk	27	27	polar	polar	JJ
cord-017764-h1w9gbxk	27	28	heterocycles	heterocycle	NNS
cord-017764-h1w9gbxk	27	29	being	be	VBG
cord-017764-h1w9gbxk	27	30	the	the	DT
cord-017764-h1w9gbxk	27	31	more	more	RBR
cord-017764-h1w9gbxk	27	32	potent	potent	JJ
cord-017764-h1w9gbxk	27	33	,	,	,
cord-017764-h1w9gbxk	27	34	while	while	IN
cord-017764-h1w9gbxk	27	35	more	more	RBR
cord-017764-h1w9gbxk	27	36	lipophilic	lipophilic	JJ
cord-017764-h1w9gbxk	27	37	substituents	substituent	NNS
cord-017764-h1w9gbxk	27	38	generally	generally	RB
cord-017764-h1w9gbxk	27	39	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	27	40	poorer	poor	JJR
cord-017764-h1w9gbxk	27	41	replicon	replicon	NN
cord-017764-h1w9gbxk	27	42	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	27	43	activity	activity	NN
cord-017764-h1w9gbxk	27	44	.	.	.
cord-017764-h1w9gbxk	28	1	Overall	overall	RB
cord-017764-h1w9gbxk	28	2	,	,	,
cord-017764-h1w9gbxk	28	3	a	a	DT
cord-017764-h1w9gbxk	28	4	good	good	JJ
cord-017764-h1w9gbxk	28	5	dynamic	dynamic	JJ
cord-017764-h1w9gbxk	28	6	range	range	NN
cord-017764-h1w9gbxk	28	7	of	of	IN
cord-017764-h1w9gbxk	28	8	potency	potency	NN
cord-017764-h1w9gbxk	28	9	was	be	VBD
cord-017764-h1w9gbxk	28	10	observed	observe	VBN
cord-017764-h1w9gbxk	28	11	with	with	IN
cord-017764-h1w9gbxk	28	12	the	the	DT
cord-017764-h1w9gbxk	28	13	structural	structural	JJ
cord-017764-h1w9gbxk	28	14	variations	variation	NNS
cord-017764-h1w9gbxk	28	15	sampled	sample	VBN
cord-017764-h1w9gbxk	28	16	,	,	,
cord-017764-h1w9gbxk	28	17	with	with	IN
cord-017764-h1w9gbxk	28	18	EC	EC	NNP
cord-017764-h1w9gbxk	28	19	50	50	CD
cord-017764-h1w9gbxk	28	20	values	value	NNS
cord-017764-h1w9gbxk	28	21	ranging	range	VBG
cord-017764-h1w9gbxk	28	22	from	from	IN
cord-017764-h1w9gbxk	28	23	10	10	CD
cord-017764-h1w9gbxk	28	24	to	to	TO
cord-017764-h1w9gbxk	28	25	2.5	2.5	CD
cord-017764-h1w9gbxk	28	26	μM.	μm.	NN
cord-017764-h1w9gbxk	28	27	However	however	RB
cord-017764-h1w9gbxk	28	28	,	,	,
cord-017764-h1w9gbxk	28	29	more	more	RBR
cord-017764-h1w9gbxk	28	30	profound	profound	JJ
cord-017764-h1w9gbxk	28	31	and	and	CC
cord-017764-h1w9gbxk	28	32	precise	precise	JJ
cord-017764-h1w9gbxk	28	33	effects	effect	NNS
cord-017764-h1w9gbxk	28	34	on	on	IN
cord-017764-h1w9gbxk	28	35	HCV	HCV	NNP
cord-017764-h1w9gbxk	28	36	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	28	37	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	28	38	potency	potency	NN
cord-017764-h1w9gbxk	28	39	were	be	VBD
cord-017764-h1w9gbxk	28	40	associated	associate	VBN
cord-017764-h1w9gbxk	28	41	with	with	IN
cord-017764-h1w9gbxk	28	42	changes	change	NNS
cord-017764-h1w9gbxk	28	43	to	to	IN
cord-017764-h1w9gbxk	28	44	the	the	DT
cord-017764-h1w9gbxk	28	45	Cbz	Cbz	NNP
cord-017764-h1w9gbxk	28	46	-	-	HYPH
cord-017764-h1w9gbxk	28	47	alanine	alanine	NN
cord-017764-h1w9gbxk	28	48	amide	amide	NN
cord-017764-h1w9gbxk	28	49	element	element	NN
cord-017764-h1w9gbxk	28	50	,	,	,
cord-017764-h1w9gbxk	28	51	with	with	IN
cord-017764-h1w9gbxk	28	52	the	the	DT
cord-017764-h1w9gbxk	28	53	key	key	JJ
cord-017764-h1w9gbxk	28	54	findings	finding	NNS
cord-017764-h1w9gbxk	28	55	summarized	summarize	VBN
cord-017764-h1w9gbxk	28	56	in	in	IN
cord-017764-h1w9gbxk	28	57	Fig	Fig	NNP
cord-017764-h1w9gbxk	28	58	.	.	.
cord-017764-h1w9gbxk	29	1	1	1	LS
cord-017764-h1w9gbxk	29	2	.	.	.
cord-017764-h1w9gbxk	30	1	The	the	DT
cord-017764-h1w9gbxk	30	2	unnatural	unnatural	JJ
cord-017764-h1w9gbxk	30	3	alanine	alanine	NN
cord-017764-h1w9gbxk	30	4	analogue	analogue	NN
cord-017764-h1w9gbxk	30	5	3	3	CD
cord-017764-h1w9gbxk	30	6	was	be	VBD
cord-017764-h1w9gbxk	30	7	170-fold	170-fold	CD
cord-017764-h1w9gbxk	30	8	less	less	RBR
cord-017764-h1w9gbxk	30	9	potent	potent	JJ
cord-017764-h1w9gbxk	30	10	,	,	,
cord-017764-h1w9gbxk	30	11	while	while	IN
cord-017764-h1w9gbxk	30	12	the	the	DT
cord-017764-h1w9gbxk	30	13	glycine	glycine	NN
cord-017764-h1w9gbxk	30	14	homologue	homologue	NN
cord-017764-h1w9gbxk	30	15	4	4	CD
cord-017764-h1w9gbxk	30	16	was	be	VBD
cord-017764-h1w9gbxk	30	17	eightfold	eightfold	RB
cord-017764-h1w9gbxk	30	18	weaker	weak	JJR
cord-017764-h1w9gbxk	30	19	than	than	IN
cord-017764-h1w9gbxk	30	20	2	2	CD
cord-017764-h1w9gbxk	30	21	.	.	.
cord-017764-h1w9gbxk	31	1	The	the	DT
cord-017764-h1w9gbxk	31	2	strong	strong	JJ
cord-017764-h1w9gbxk	31	3	dependence	dependence	NN
cord-017764-h1w9gbxk	31	4	of	of	IN
cord-017764-h1w9gbxk	31	5	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	31	6	activity	activity	NN
cord-017764-h1w9gbxk	31	7	on	on	IN
cord-017764-h1w9gbxk	31	8	the	the	DT
cord-017764-h1w9gbxk	31	9	absolute	absolute	JJ
cord-017764-h1w9gbxk	31	10	configuration	configuration	NN
cord-017764-h1w9gbxk	31	11	of	of	IN
cord-017764-h1w9gbxk	31	12	the	the	DT
cord-017764-h1w9gbxk	31	13	amino	amino	NN
cord-017764-h1w9gbxk	31	14	acid	acid	NN
cord-017764-h1w9gbxk	31	15	element	element	NN
cord-017764-h1w9gbxk	31	16	was	be	VBD
cord-017764-h1w9gbxk	31	17	reproduced	reproduce	VBN
cord-017764-h1w9gbxk	31	18	in	in	IN
cord-017764-h1w9gbxk	31	19	the	the	DT
cord-017764-h1w9gbxk	31	20	proline	proline	NN
cord-017764-h1w9gbxk	31	21	derivatives	derivative	NNS
cord-017764-h1w9gbxk	31	22	5	5	CD
cord-017764-h1w9gbxk	31	23	and	and	CC
cord-017764-h1w9gbxk	31	24	6	6	CD
cord-017764-h1w9gbxk	31	25	,	,	,
cord-017764-h1w9gbxk	31	26	both	both	DT
cord-017764-h1w9gbxk	31	27	of	of	IN
cord-017764-h1w9gbxk	31	28	which	which	WDT
cord-017764-h1w9gbxk	31	29	were	be	VBD
cord-017764-h1w9gbxk	31	30	fivefold	fivefold	RB
cord-017764-h1w9gbxk	31	31	more	more	RBR
cord-017764-h1w9gbxk	31	32	potent	potent	JJ
cord-017764-h1w9gbxk	31	33	than	than	IN
cord-017764-h1w9gbxk	31	34	their	-PRON-	PRP$
cord-017764-h1w9gbxk	31	35	alanine	alanine	JJ
cord-017764-h1w9gbxk	31	36	congeners	congener	NNS
cord-017764-h1w9gbxk	31	37	[	[	-LRB-
cord-017764-h1w9gbxk	31	38	15	15	CD
cord-017764-h1w9gbxk	31	39	]	]	-RRB-
cord-017764-h1w9gbxk	31	40	.	.	.
cord-017764-h1w9gbxk	32	1	Replacing	replace	VBG
cord-017764-h1w9gbxk	32	2	the	the	DT
cord-017764-h1w9gbxk	32	3	Cbz	Cbz	NNP
cord-017764-h1w9gbxk	32	4	element	element	NN
cord-017764-h1w9gbxk	32	5	with	with	IN
cord-017764-h1w9gbxk	32	6	a	a	DT
cord-017764-h1w9gbxk	32	7	dihydrocinnamate	dihydrocinnamate	JJ
cord-017764-h1w9gbxk	32	8	moiety	moiety	NN
cord-017764-h1w9gbxk	32	9	resulted	result	VBD
cord-017764-h1w9gbxk	32	10	in	in	IN
cord-017764-h1w9gbxk	32	11	an	an	DT
cord-017764-h1w9gbxk	32	12	erosion	erosion	NN
cord-017764-h1w9gbxk	32	13	of	of	IN
cord-017764-h1w9gbxk	32	14	potency	potency	NN
cord-017764-h1w9gbxk	32	15	in	in	IN
cord-017764-h1w9gbxk	32	16	both	both	DT
cord-017764-h1w9gbxk	32	17	series	series	NN
cord-017764-h1w9gbxk	32	18	,	,	,
cord-017764-h1w9gbxk	32	19	as	as	IN
cord-017764-h1w9gbxk	32	20	exemplified	exemplify	VBN
cord-017764-h1w9gbxk	32	21	by	by	IN
cord-017764-h1w9gbxk	32	22	7	7	CD
cord-017764-h1w9gbxk	32	23	and	and	CC
cord-017764-h1w9gbxk	32	24	9	9	CD
cord-017764-h1w9gbxk	32	25	.	.	.
cord-017764-h1w9gbxk	33	1	However	however	RB
cord-017764-h1w9gbxk	33	2	,	,	,
cord-017764-h1w9gbxk	33	3	a	a	DT
cord-017764-h1w9gbxk	33	4	significant	significant	JJ
cord-017764-h1w9gbxk	33	5	increase	increase	NN
cord-017764-h1w9gbxk	33	6	in	in	IN
cord-017764-h1w9gbxk	33	7	potency	potency	NN
cord-017764-h1w9gbxk	33	8	was	be	VBD
cord-017764-h1w9gbxk	33	9	observed	observe	VBN
cord-017764-h1w9gbxk	33	10	with	with	IN
cord-017764-h1w9gbxk	33	11	the	the	DT
cord-017764-h1w9gbxk	33	12	phenylacetamide	phenylacetamide	NN
cord-017764-h1w9gbxk	33	13	moiety	moiety	NN
cord-017764-h1w9gbxk	33	14	found	find	VBD
cord-017764-h1w9gbxk	33	15	in	in	IN
cord-017764-h1w9gbxk	33	16	8	8	CD
cord-017764-h1w9gbxk	33	17	and	and	CC
cord-017764-h1w9gbxk	33	18	10	10	CD
cord-017764-h1w9gbxk	33	19	,	,	,
cord-017764-h1w9gbxk	33	20	with	with	IN
cord-017764-h1w9gbxk	33	21	both	both	DT
cord-017764-h1w9gbxk	33	22	compounds	compound	NNS
cord-017764-h1w9gbxk	33	23	expressing	express	VBG
cord-017764-h1w9gbxk	33	24	single	single	JJ
cord-017764-h1w9gbxk	33	25	digit	digit	NN
cord-017764-h1w9gbxk	33	26	nanomolar	nanomolar	JJ
cord-017764-h1w9gbxk	33	27	EC	EC	NNP
cord-017764-h1w9gbxk	33	28	50	50	CD
cord-017764-h1w9gbxk	33	29	values	value	NNS
cord-017764-h1w9gbxk	33	30	in	in	IN
cord-017764-h1w9gbxk	33	31	the	the	DT
cord-017764-h1w9gbxk	33	32	replicon	replicon	NN
cord-017764-h1w9gbxk	33	33	and	and	CC
cord-017764-h1w9gbxk	33	34	confirming	confirm	VBG
cord-017764-h1w9gbxk	33	35	the	the	DT
cord-017764-h1w9gbxk	33	36	inherent	inherent	JJ
cord-017764-h1w9gbxk	33	37	advantage	advantage	NN
cord-017764-h1w9gbxk	33	38	offered	offer	VBN
cord-017764-h1w9gbxk	33	39	by	by	IN
cord-017764-h1w9gbxk	33	40	proline	proline	NN
cord-017764-h1w9gbxk	33	41	.	.	.
cord-017764-h1w9gbxk	34	1	Only	only	RB
cord-017764-h1w9gbxk	34	2	weak	weak	JJ
cord-017764-h1w9gbxk	34	3	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	34	4	effects	effect	NNS
cord-017764-h1w9gbxk	34	5	were	be	VBD
cord-017764-h1w9gbxk	34	6	observed	observe	VBN
cord-017764-h1w9gbxk	34	7	with	with	IN
cord-017764-h1w9gbxk	34	8	the	the	DT
cord-017764-h1w9gbxk	34	9	many	many	JJ
cord-017764-h1w9gbxk	34	10	other	other	JJ
cord-017764-h1w9gbxk	34	11	amino	amino	NN
cord-017764-h1w9gbxk	34	12	acids	acid	NNS
cord-017764-h1w9gbxk	34	13	and	and	CC
cord-017764-h1w9gbxk	34	14	additional	additional	JJ
cord-017764-h1w9gbxk	34	15	structural	structural	JJ
cord-017764-h1w9gbxk	34	16	variations	variation	NNS
cord-017764-h1w9gbxk	34	17	that	that	WDT
cord-017764-h1w9gbxk	34	18	were	be	VBD
cord-017764-h1w9gbxk	34	19	explored	explore	VBN
cord-017764-h1w9gbxk	34	20	at	at	IN
cord-017764-h1w9gbxk	34	21	this	this	DT
cord-017764-h1w9gbxk	34	22	site	site	NN
cord-017764-h1w9gbxk	34	23	of	of	IN
cord-017764-h1w9gbxk	34	24	the	the	DT
cord-017764-h1w9gbxk	34	25	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	34	26	,	,	,
cord-017764-h1w9gbxk	34	27	with	with	IN
cord-017764-h1w9gbxk	34	28	some	some	DT
cord-017764-h1w9gbxk	34	29	representative	representative	JJ
cord-017764-h1w9gbxk	34	30	examples	example	NNS
cord-017764-h1w9gbxk	34	31	of	of	IN
cord-017764-h1w9gbxk	34	32	those	those	DT
cord-017764-h1w9gbxk	34	33	sampled	sample	VBN
cord-017764-h1w9gbxk	34	34	compiled	compile	VBN
cord-017764-h1w9gbxk	34	35	in	in	IN
cord-017764-h1w9gbxk	34	36	Fig	Fig	NNP
cord-017764-h1w9gbxk	34	37	.	.	.
cord-017764-h1w9gbxk	35	1	2	2	LS
cord-017764-h1w9gbxk	35	2	[	[	-LRB-
cord-017764-h1w9gbxk	35	3	15	15	CD
cord-017764-h1w9gbxk	35	4	]	]	-RRB-
cord-017764-h1w9gbxk	35	5	.	.	.
cord-017764-h1w9gbxk	36	1	While	while	IN
cord-017764-h1w9gbxk	36	2	these	these	DT
cord-017764-h1w9gbxk	36	3	collective	collective	JJ
cord-017764-h1w9gbxk	36	4	SARs	sar	NNS
cord-017764-h1w9gbxk	36	5	appeared	appear	VBD
cord-017764-h1w9gbxk	36	6	to	to	TO
cord-017764-h1w9gbxk	36	7	be	be	VB
cord-017764-h1w9gbxk	36	8	coherent	coherent	JJ
cord-017764-h1w9gbxk	36	9	and	and	CC
cord-017764-h1w9gbxk	36	10	were	be	VBD
cord-017764-h1w9gbxk	36	11	readily	readily	RB
cord-017764-h1w9gbxk	36	12	interpretable	interpretable	JJ
cord-017764-h1w9gbxk	36	13	,	,	,
cord-017764-h1w9gbxk	36	14	as	as	IN
cord-017764-h1w9gbxk	36	15	highlighted	highlight	VBN
cord-017764-h1w9gbxk	36	16	by	by	IN
cord-017764-h1w9gbxk	36	17	the	the	DT
cord-017764-h1w9gbxk	36	18	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	36	19	of	of	IN
cord-017764-h1w9gbxk	36	20	potency	potency	NN
cord-017764-h1w9gbxk	36	21	to	to	IN
cord-017764-h1w9gbxk	36	22	changes	change	NNS
cord-017764-h1w9gbxk	36	23	to	to	IN
cord-017764-h1w9gbxk	36	24	the	the	DT
cord-017764-h1w9gbxk	36	25	amino	amino	NN
cord-017764-h1w9gbxk	36	26	acid	acid	NN
cord-017764-h1w9gbxk	36	27	element	element	NN
cord-017764-h1w9gbxk	36	28	,	,	,
cord-017764-h1w9gbxk	36	29	as	as	IN
cord-017764-h1w9gbxk	36	30	exploration	exploration	NN
cord-017764-h1w9gbxk	36	31	of	of	IN
cord-017764-h1w9gbxk	36	32	2	2	CD
cord-017764-h1w9gbxk	36	33	and	and	CC
cord-017764-h1w9gbxk	36	34	its	-PRON-	PRP$
cord-017764-h1w9gbxk	36	35	analogues	analogue	NNS
cord-017764-h1w9gbxk	36	36	continued	continue	VBD
cord-017764-h1w9gbxk	36	37	,	,	,
cord-017764-h1w9gbxk	36	38	it	-PRON-	PRP
cord-017764-h1w9gbxk	36	39	became	become	VBD
cord-017764-h1w9gbxk	36	40	apparent	apparent	JJ
cord-017764-h1w9gbxk	36	41	that	that	IN
cord-017764-h1w9gbxk	36	42	the	the	DT
cord-017764-h1w9gbxk	36	43	iminothiazolidinone	iminothiazolidinone	NNP
cord-017764-h1w9gbxk	36	44	chemotype	chemotype	NNP
cord-017764-h1w9gbxk	36	45	was	be	VBD
cord-017764-h1w9gbxk	36	46	unstable	unstable	JJ
cord-017764-h1w9gbxk	36	47	under	under	IN
cord-017764-h1w9gbxk	36	48	some	some	DT
cord-017764-h1w9gbxk	36	49	conditions	condition	NNS
cord-017764-h1w9gbxk	36	50	[	[	-LRB-
cord-017764-h1w9gbxk	36	51	15	15	CD
cord-017764-h1w9gbxk	36	52	,	,	,
cord-017764-h1w9gbxk	36	53	22	22	CD
cord-017764-h1w9gbxk	36	54	]	]	-RRB-
cord-017764-h1w9gbxk	36	55	.	.	.
cord-017764-h1w9gbxk	37	1	The	the	DT
cord-017764-h1w9gbxk	37	2	first	first	JJ
cord-017764-h1w9gbxk	37	3	indication	indication	NN
cord-017764-h1w9gbxk	37	4	of	of	IN
cord-017764-h1w9gbxk	37	5	a	a	DT
cord-017764-h1w9gbxk	37	6	problem	problem	NN
cord-017764-h1w9gbxk	37	7	was	be	VBD
cord-017764-h1w9gbxk	37	8	the	the	DT
cord-017764-h1w9gbxk	37	9	observation	observation	NN
cord-017764-h1w9gbxk	37	10	that	that	IN
cord-017764-h1w9gbxk	37	11	a	a	DT
cord-017764-h1w9gbxk	37	12	sample	sample	NN
cord-017764-h1w9gbxk	37	13	of	of	IN
cord-017764-h1w9gbxk	37	14	2	2	CD
cord-017764-h1w9gbxk	37	15	degraded	degrade	VBN
cord-017764-h1w9gbxk	37	16	upon	upon	IN
cord-017764-h1w9gbxk	37	17	standing	stand	VBG
cord-017764-h1w9gbxk	37	18	as	as	IN
cord-017764-h1w9gbxk	37	19	a	a	DT
cord-017764-h1w9gbxk	37	20	solution	solution	NN
cord-017764-h1w9gbxk	37	21	in	in	IN
cord-017764-h1w9gbxk	37	22	DMSO	DMSO	NNP
cord-017764-h1w9gbxk	37	23	for	for	IN
cord-017764-h1w9gbxk	37	24	several	several	JJ
cord-017764-h1w9gbxk	37	25	days	day	NNS
cord-017764-h1w9gbxk	37	26	,	,	,
cord-017764-h1w9gbxk	37	27	with	with	IN
cord-017764-h1w9gbxk	37	28	the	the	DT
cord-017764-h1w9gbxk	37	29	thiohydantoin	thiohydantoin	NNP
cord-017764-h1w9gbxk	37	30	15	15	CD
cord-017764-h1w9gbxk	37	31	(	(	-LRB-
cord-017764-h1w9gbxk	37	32	R	R	NNP
cord-017764-h1w9gbxk	37	33	3	3	CD
cord-017764-h1w9gbxk	37	34	¼	¼	NN
cord-017764-h1w9gbxk	37	35	NHCO	NHCO	NNP
cord-017764-h1w9gbxk	37	36	2	2	CD
cord-017764-h1w9gbxk	37	37	CH	CH	NNP
cord-017764-h1w9gbxk	37	38	2	2	CD
cord-017764-h1w9gbxk	37	39	Ph	Ph	NNP
cord-017764-h1w9gbxk	37	40	)	)	-RRB-
cord-017764-h1w9gbxk	37	41	and	and	CC
cord-017764-h1w9gbxk	37	42	thiourea	thiourea	NN
cord-017764-h1w9gbxk	37	43	17	17	CD
cord-017764-h1w9gbxk	37	44	(	(	-LRB-
cord-017764-h1w9gbxk	37	45	R	r	NN
cord-017764-h1w9gbxk	37	46	3	3	CD
cord-017764-h1w9gbxk	37	47	¼	¼	NN
cord-017764-h1w9gbxk	37	48	NHCO	NHCO	NNP
cord-017764-h1w9gbxk	37	49	2	2	CD
cord-017764-h1w9gbxk	37	50	CH	CH	NNP
cord-017764-h1w9gbxk	37	51	2	2	CD
cord-017764-h1w9gbxk	37	52	Ph	Ph	NNP
cord-017764-h1w9gbxk	37	53	)	)	-RRB-
cord-017764-h1w9gbxk	37	54	determined	determine	VBD
cord-017764-h1w9gbxk	37	55	to	to	TO
cord-017764-h1w9gbxk	37	56	be	be	VB
cord-017764-h1w9gbxk	37	57	two	two	CD
cord-017764-h1w9gbxk	37	58	of	of	IN
cord-017764-h1w9gbxk	37	59	the	the	DT
cord-017764-h1w9gbxk	37	60	degradation	degradation	NN
cord-017764-h1w9gbxk	37	61	products	product	NNS
cord-017764-h1w9gbxk	37	62	after	after	IN
cord-017764-h1w9gbxk	37	63	a	a	DT
cord-017764-h1w9gbxk	37	64	preparative	preparative	JJ
cord-017764-h1w9gbxk	37	65	experiment	experiment	NN
cord-017764-h1w9gbxk	37	66	(	(	-LRB-
cord-017764-h1w9gbxk	37	67	Scheme	scheme	NN
cord-017764-h1w9gbxk	37	68	1	1	CD
cord-017764-h1w9gbxk	37	69	)	)	-RRB-
cord-017764-h1w9gbxk	37	70	.	.	.
cord-017764-h1w9gbxk	38	1	In	in	IN
cord-017764-h1w9gbxk	38	2	the	the	DT
cord-017764-h1w9gbxk	38	3	replicon	replicon	NN
cord-017764-h1w9gbxk	38	4	,	,	,
cord-017764-h1w9gbxk	38	5	15	15	CD
cord-017764-h1w9gbxk	38	6	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	38	7	a	a	DT
cord-017764-h1w9gbxk	38	8	modest	modest	JJ
cord-017764-h1w9gbxk	38	9	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	38	10	activity	activity	NN
cord-017764-h1w9gbxk	38	11	,	,	,
cord-017764-h1w9gbxk	38	12	EC	EC	NNP
cord-017764-h1w9gbxk	38	13	50	50	CD
cord-017764-h1w9gbxk	38	14	while	while	IN
cord-017764-h1w9gbxk	38	15	17	17	CD
cord-017764-h1w9gbxk	38	16	was	be	VBD
cord-017764-h1w9gbxk	38	17	essentially	essentially	RB
cord-017764-h1w9gbxk	38	18	inactive	inactive	JJ
cord-017764-h1w9gbxk	38	19	.	.	.
cord-017764-h1w9gbxk	39	1	Compounding	compound	VBG
cord-017764-h1w9gbxk	39	2	the	the	DT
cord-017764-h1w9gbxk	39	3	intrigue	intrigue	NN
cord-017764-h1w9gbxk	39	4	,	,	,
cord-017764-h1w9gbxk	39	5	incubating	incubate	VBG
cord-017764-h1w9gbxk	39	6	the	the	DT
cord-017764-h1w9gbxk	39	7	more	more	RBR
cord-017764-h1w9gbxk	39	8	potent	potent	JJ
cord-017764-h1w9gbxk	39	9	8	8	CD
cord-017764-h1w9gbxk	39	10	in	in	IN
cord-017764-h1w9gbxk	39	11	replicon	replicon	NN
cord-017764-h1w9gbxk	39	12	media	medium	NNS
cord-017764-h1w9gbxk	39	13	until	until	IN
cord-017764-h1w9gbxk	39	14	degradation	degradation	NN
cord-017764-h1w9gbxk	39	15	was	be	VBD
cord-017764-h1w9gbxk	39	16	complete	complete	JJ
cord-017764-h1w9gbxk	39	17	and	and	CC
cord-017764-h1w9gbxk	39	18	then	then	RB
cord-017764-h1w9gbxk	39	19	assessing	assess	VBG
cord-017764-h1w9gbxk	39	20	the	the	DT
cord-017764-h1w9gbxk	39	21	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	39	22	activity	activity	NN
cord-017764-h1w9gbxk	39	23	of	of	IN
cord-017764-h1w9gbxk	39	24	the	the	DT
cord-017764-h1w9gbxk	39	25	preparation	preparation	NN
cord-017764-h1w9gbxk	39	26	in	in	IN
cord-017764-h1w9gbxk	39	27	the	the	DT
cord-017764-h1w9gbxk	39	28	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	39	29	replicon	replicon	NN
cord-017764-h1w9gbxk	39	30	demonstrated	demonstrate	VBD
cord-017764-h1w9gbxk	39	31	that	that	IN
cord-017764-h1w9gbxk	39	32	the	the	DT
cord-017764-h1w9gbxk	39	33	HCV	HCV	NNP
cord-017764-h1w9gbxk	39	34	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	39	35	activity	activity	NN
cord-017764-h1w9gbxk	39	36	and	and	CC
cord-017764-h1w9gbxk	39	37	potency	potency	NN
cord-017764-h1w9gbxk	39	38	were	be	VBD
cord-017764-h1w9gbxk	39	39	fully	fully	RB
cord-017764-h1w9gbxk	39	40	preserved	preserve	VBN
cord-017764-h1w9gbxk	39	41	[	[	-LRB-
cord-017764-h1w9gbxk	39	42	15	15	CD
cord-017764-h1w9gbxk	39	43	,	,	,
cord-017764-h1w9gbxk	39	44	22	22	CD
cord-017764-h1w9gbxk	39	45	]	]	-RRB-
cord-017764-h1w9gbxk	39	46	.	.	.
cord-017764-h1w9gbxk	40	1	A	a	DT
cord-017764-h1w9gbxk	40	2	more	more	RBR
cord-017764-h1w9gbxk	40	3	detailed	detailed	JJ
cord-017764-h1w9gbxk	40	4	analysis	analysis	NN
cord-017764-h1w9gbxk	40	5	of	of	IN
cord-017764-h1w9gbxk	40	6	the	the	DT
cord-017764-h1w9gbxk	40	7	degradation	degradation	NN
cord-017764-h1w9gbxk	40	8	products	product	NNS
cord-017764-h1w9gbxk	40	9	from	from	IN
cord-017764-h1w9gbxk	40	10	8	8	CD
cord-017764-h1w9gbxk	40	11	guided	guide	VBN
cord-017764-h1w9gbxk	40	12	by	by	IN
cord-017764-h1w9gbxk	40	13	high	high	JJ
cord-017764-h1w9gbxk	40	14	-	-	HYPH
cord-017764-h1w9gbxk	40	15	performance	performance	NN
cord-017764-h1w9gbxk	40	16	liquid	liquid	NN
cord-017764-h1w9gbxk	40	17	chromatography	chromatography	NN
cord-017764-h1w9gbxk	40	18	(	(	-LRB-
cord-017764-h1w9gbxk	40	19	HPLC	HPLC	NNP
cord-017764-h1w9gbxk	40	20	)	)	-RRB-
cord-017764-h1w9gbxk	40	21	biogram	biogram	NNP
cord-017764-h1w9gbxk	40	22	analysis	analysis	NN
cord-017764-h1w9gbxk	40	23	,	,	,
cord-017764-h1w9gbxk	40	24	in	in	IN
cord-017764-h1w9gbxk	40	25	which	which	WDT
cord-017764-h1w9gbxk	40	26	fractions	fraction	NNS
cord-017764-h1w9gbxk	40	27	taken	take	VBN
cord-017764-h1w9gbxk	40	28	from	from	IN
cord-017764-h1w9gbxk	40	29	the	the	DT
cord-017764-h1w9gbxk	40	30	chromatography	chromatography	NN
cord-017764-h1w9gbxk	40	31	column	column	NN
cord-017764-h1w9gbxk	40	32	are	be	VBP
cord-017764-h1w9gbxk	40	33	concentrated	concentrate	VBN
cord-017764-h1w9gbxk	40	34	and	and	CC
cord-017764-h1w9gbxk	40	35	assessed	assess	VBN
cord-017764-h1w9gbxk	40	36	for	for	IN
cord-017764-h1w9gbxk	40	37	replicon	replicon	NN
cord-017764-h1w9gbxk	40	38	inhibition	inhibition	NN
cord-017764-h1w9gbxk	40	39	,	,	,
cord-017764-h1w9gbxk	40	40	led	lead	VBD
cord-017764-h1w9gbxk	40	41	to	to	IN
cord-017764-h1w9gbxk	40	42	the	the	DT
cord-017764-h1w9gbxk	40	43	identification	identification	NN
cord-017764-h1w9gbxk	40	44	of	of	IN
cord-017764-h1w9gbxk	40	45	two	two	CD
cord-017764-h1w9gbxk	40	46	potent	potent	JJ
cord-017764-h1w9gbxk	40	47	constituents	constituent	NNS
cord-017764-h1w9gbxk	40	48	present	present	JJ
cord-017764-h1w9gbxk	40	49	in	in	IN
cord-017764-h1w9gbxk	40	50	just	just	JJ
cord-017764-h1w9gbxk	40	51	trace	trace	NN
cord-017764-h1w9gbxk	40	52	amounts	amount	NNS
cord-017764-h1w9gbxk	40	53	in	in	IN
cord-017764-h1w9gbxk	40	54	the	the	DT
cord-017764-h1w9gbxk	40	55	cell	cell	NN
cord-017764-h1w9gbxk	40	56	media	medium	NNS
cord-017764-h1w9gbxk	40	57	[	[	-LRB-
cord-017764-h1w9gbxk	40	58	22	22	CD
cord-017764-h1w9gbxk	40	59	,	,	,
cord-017764-h1w9gbxk	40	60	23	23	CD
cord-017764-h1w9gbxk	40	61	]	]	-RRB-
cord-017764-h1w9gbxk	40	62	.	.	.
cord-017764-h1w9gbxk	41	1	A	a	DT
cord-017764-h1w9gbxk	41	2	preparative	preparative	JJ
cord-017764-h1w9gbxk	41	3	experiment	experiment	NN
cord-017764-h1w9gbxk	41	4	allowed	allow	VBD
cord-017764-h1w9gbxk	41	5	isolation	isolation	NN
cord-017764-h1w9gbxk	41	6	of	of	IN
cord-017764-h1w9gbxk	41	7	a	a	DT
cord-017764-h1w9gbxk	41	8	sufficient	sufficient	JJ
cord-017764-h1w9gbxk	41	9	quantity	quantity	NN
cord-017764-h1w9gbxk	41	10	of	of	IN
cord-017764-h1w9gbxk	41	11	each	each	DT
cord-017764-h1w9gbxk	41	12	component	component	NN
cord-017764-h1w9gbxk	41	13	to	to	TO
cord-017764-h1w9gbxk	41	14	allow	allow	VB
cord-017764-h1w9gbxk	41	15	for	for	IN
cord-017764-h1w9gbxk	41	16	a	a	DT
cord-017764-h1w9gbxk	41	17	more	more	RBR
cord-017764-h1w9gbxk	41	18	detailed	detailed	JJ
cord-017764-h1w9gbxk	41	19	characterization	characterization	NN
cord-017764-h1w9gbxk	41	20	.	.	.
cord-017764-h1w9gbxk	42	1	1	1	CD
cord-017764-h1w9gbxk	42	2	H	H	NNP
cord-017764-h1w9gbxk	42	3	-	-	HYPH
cord-017764-h1w9gbxk	42	4	NMR	NMR	NNP
cord-017764-h1w9gbxk	42	5	and	and	CC
cord-017764-h1w9gbxk	42	6	mass	mass	JJ
cord-017764-h1w9gbxk	42	7	spectrum	spectrum	NN
cord-017764-h1w9gbxk	42	8	analyses	analysis	NNS
cord-017764-h1w9gbxk	42	9	indicated	indicate	VBD
cord-017764-h1w9gbxk	42	10	that	that	IN
cord-017764-h1w9gbxk	42	11	the	the	DT
cord-017764-h1w9gbxk	42	12	two	two	CD
cord-017764-h1w9gbxk	42	13	compounds	compound	NNS
cord-017764-h1w9gbxk	42	14	were	be	VBD
cord-017764-h1w9gbxk	42	15	dimers	dimer	NNS
cord-017764-h1w9gbxk	42	16	with	with	IN
cord-017764-h1w9gbxk	42	17	an	an	DT
cord-017764-h1w9gbxk	42	18	isomeric	isomeric	JJ
cord-017764-h1w9gbxk	42	19	relationship	relationship	NN
cord-017764-h1w9gbxk	42	20	and	and	CC
cord-017764-h1w9gbxk	42	21	assigned	assign	VBN
cord-017764-h1w9gbxk	42	22	as	as	IN
cord-017764-h1w9gbxk	42	23	18	18	CD
cord-017764-h1w9gbxk	42	24	based	base	VBN
cord-017764-h1w9gbxk	42	25	on	on	IN
cord-017764-h1w9gbxk	42	26	the	the	DT
cord-017764-h1w9gbxk	42	27	absence	absence	NN
cord-017764-h1w9gbxk	42	28	of	of	IN
cord-017764-h1w9gbxk	42	29	the	the	DT
cord-017764-h1w9gbxk	42	30	C-5	C-5	NNP
cord-017764-h1w9gbxk	42	31	hydrogen	hydrogen	NN
cord-017764-h1w9gbxk	42	32	atom	atom	NN
cord-017764-h1w9gbxk	42	33	of	of	IN
cord-017764-h1w9gbxk	42	34	the	the	DT
cord-017764-h1w9gbxk	42	35	iminothiazolidinone	iminothiazolidinone	NN
cord-017764-h1w9gbxk	42	36	ring	ring	NN
cord-017764-h1w9gbxk	42	37	in	in	IN
cord-017764-h1w9gbxk	42	38	the	the	DT
cord-017764-h1w9gbxk	42	39	1	1	CD
cord-017764-h1w9gbxk	42	40	H	H	NNP
cord-017764-h1w9gbxk	42	41	-	-	HYPH
cord-017764-h1w9gbxk	42	42	NMR	nmr	NN
cord-017764-h1w9gbxk	42	43	spectrum	spectrum	NN
cord-017764-h1w9gbxk	42	44	and	and	CC
cord-017764-h1w9gbxk	42	45	connectivity	connectivity	NN
cord-017764-h1w9gbxk	42	46	that	that	WDT
cord-017764-h1w9gbxk	42	47	was	be	VBD
cord-017764-h1w9gbxk	42	48	confirmed	confirm	VBN
cord-017764-h1w9gbxk	42	49	after	after	IN
cord-017764-h1w9gbxk	42	50	the	the	DT
cord-017764-h1w9gbxk	42	51	analysis	analysis	NN
cord-017764-h1w9gbxk	42	52	of	of	IN
cord-017764-h1w9gbxk	42	53	the	the	DT
cord-017764-h1w9gbxk	42	54	13	13	CD
cord-017764-h1w9gbxk	42	55	C	C	NNP
cord-017764-h1w9gbxk	42	56	-	-	HYPH
cord-017764-h1w9gbxk	42	57	NMR	NMR	NNP
cord-017764-h1w9gbxk	42	58	spectrum	spectrum	NN
cord-017764-h1w9gbxk	42	59	.	.	.
cord-017764-h1w9gbxk	43	1	Although	although	IN
cord-017764-h1w9gbxk	43	2	neither	neither	CC
cord-017764-h1w9gbxk	43	3	the	the	DT
cord-017764-h1w9gbxk	43	4	exact	exact	JJ
cord-017764-h1w9gbxk	43	5	stereo	stereo	NN
cord-017764-h1w9gbxk	43	6	-	-	HYPH
cord-017764-h1w9gbxk	43	7	composition	composition	NN
cord-017764-h1w9gbxk	43	8	of	of	IN
cord-017764-h1w9gbxk	43	9	the	the	DT
cord-017764-h1w9gbxk	43	10	benzylic	benzylic	JJ
cord-017764-h1w9gbxk	43	11	centers	center	NNS
cord-017764-h1w9gbxk	43	12	of	of	IN
cord-017764-h1w9gbxk	43	13	18	18	CD
cord-017764-h1w9gbxk	43	14	nor	nor	CC
cord-017764-h1w9gbxk	43	15	the	the	DT
cord-017764-h1w9gbxk	43	16	precise	precise	JJ
cord-017764-h1w9gbxk	43	17	relationship	relationship	NN
cord-017764-h1w9gbxk	43	18	between	between	IN
cord-017764-h1w9gbxk	43	19	these	these	DT
cord-017764-h1w9gbxk	43	20	two	two	CD
cord-017764-h1w9gbxk	43	21	compounds	compound	NNS
cord-017764-h1w9gbxk	43	22	was	be	VBD
cord-017764-h1w9gbxk	43	23	determined	determine	VBN
cord-017764-h1w9gbxk	43	24	,	,	,
cord-017764-h1w9gbxk	43	25	it	-PRON-	PRP
cord-017764-h1w9gbxk	43	26	is	be	VBZ
cord-017764-h1w9gbxk	43	27	of	of	IN
cord-017764-h1w9gbxk	43	28	note	note	NN
cord-017764-h1w9gbxk	43	29	that	that	IN
cord-017764-h1w9gbxk	43	30	the	the	DT
cord-017764-h1w9gbxk	43	31	isomer	isomer	NN
cord-017764-h1w9gbxk	43	32	that	that	WDT
cord-017764-h1w9gbxk	43	33	was	be	VBD
cord-017764-h1w9gbxk	43	34	less	less	RBR
cord-017764-h1w9gbxk	43	35	mobile	mobile	JJ
cord-017764-h1w9gbxk	43	36	on	on	IN
cord-017764-h1w9gbxk	43	37	a	a	DT
cord-017764-h1w9gbxk	43	38	reversed	reversed	JJ
cord-017764-h1w9gbxk	43	39	phase	phase	NN
cord-017764-h1w9gbxk	43	40	column	column	NN
cord-017764-h1w9gbxk	43	41	converted	convert	VBN
cord-017764-h1w9gbxk	43	42	to	to	IN
cord-017764-h1w9gbxk	43	43	the	the	DT
cord-017764-h1w9gbxk	43	44	more	more	RBR
cord-017764-h1w9gbxk	43	45	mobile	mobile	JJ
cord-017764-h1w9gbxk	43	46	isomer	isomer	NN
cord-017764-h1w9gbxk	43	47	upon	upon	IN
cord-017764-h1w9gbxk	43	48	heating	heating	NN
cord-017764-h1w9gbxk	43	49	in	in	IN
cord-017764-h1w9gbxk	43	50	CD	CD	NNP
cord-017764-h1w9gbxk	43	51	3	3	CD
cord-017764-h1w9gbxk	43	52	CN	cn	NN
cord-017764-h1w9gbxk	43	53	at	at	IN
cord-017764-h1w9gbxk	43	54	50	50	CD
cord-017764-h1w9gbxk	43	55	C	c	NN
cord-017764-h1w9gbxk	43	56	,	,	,
cord-017764-h1w9gbxk	43	57	an	an	DT
cord-017764-h1w9gbxk	43	58	observation	observation	NN
cord-017764-h1w9gbxk	43	59	made	make	VBN
cord-017764-h1w9gbxk	43	60	while	while	IN
cord-017764-h1w9gbxk	43	61	conducting	conduct	VBG
cord-017764-h1w9gbxk	43	62	an	an	DT
cord-017764-h1w9gbxk	43	63	NMR	NMR	NNP
cord-017764-h1w9gbxk	43	64	experiment	experiment	NN
cord-017764-h1w9gbxk	43	65	as	as	IN
cord-017764-h1w9gbxk	43	66	part	part	NN
cord-017764-h1w9gbxk	43	67	of	of	IN
cord-017764-h1w9gbxk	43	68	the	the	DT
cord-017764-h1w9gbxk	43	69	structure	structure	NN
cord-017764-h1w9gbxk	43	70	determination	determination	NN
cord-017764-h1w9gbxk	43	71	process	process	NN
cord-017764-h1w9gbxk	43	72	[	[	-LRB-
cord-017764-h1w9gbxk	43	73	22	22	CD
cord-017764-h1w9gbxk	43	74	]	]	-RRB-
cord-017764-h1w9gbxk	43	75	.	.	.
cord-017764-h1w9gbxk	44	1	With	with	IN
cord-017764-h1w9gbxk	44	2	the	the	DT
cord-017764-h1w9gbxk	44	3	acquisition	acquisition	NN
cord-017764-h1w9gbxk	44	4	of	of	IN
cord-017764-h1w9gbxk	44	5	these	these	DT
cord-017764-h1w9gbxk	44	6	data	datum	NNS
cord-017764-h1w9gbxk	44	7	,	,	,
cord-017764-h1w9gbxk	44	8	the	the	DT
cord-017764-h1w9gbxk	44	9	mechanistically	mechanistically	RB
cord-017764-h1w9gbxk	44	10	holistic	holistic	JJ
cord-017764-h1w9gbxk	44	11	picture	picture	NN
cord-017764-h1w9gbxk	44	12	of	of	IN
cord-017764-h1w9gbxk	44	13	the	the	DT
cord-017764-h1w9gbxk	44	14	degradation	degradation	NN
cord-017764-h1w9gbxk	44	15	process	process	NN
cord-017764-h1w9gbxk	44	16	that	that	WDT
cord-017764-h1w9gbxk	44	17	is	be	VBZ
cord-017764-h1w9gbxk	44	18	presented	present	VBN
cord-017764-h1w9gbxk	44	19	in	in	IN
cord-017764-h1w9gbxk	44	20	Scheme	scheme	NN
cord-017764-h1w9gbxk	44	21	1	1	CD
cord-017764-h1w9gbxk	44	22	was	be	VBD
cord-017764-h1w9gbxk	44	23	proposed	propose	VBN
cord-017764-h1w9gbxk	44	24	.	.	.
cord-017764-h1w9gbxk	45	1	Abstraction	abstraction	NN
cord-017764-h1w9gbxk	45	2	of	of	IN
cord-017764-h1w9gbxk	45	3	the	the	DT
cord-017764-h1w9gbxk	45	4	C-5	C-5	NNP
cord-017764-h1w9gbxk	45	5	hydrogen	hydrogen	NN
cord-017764-h1w9gbxk	45	6	atom	atom	NN
cord-017764-h1w9gbxk	45	7	of	of	IN
cord-017764-h1w9gbxk	45	8	8	8	CD
cord-017764-h1w9gbxk	45	9	by	by	IN
cord-017764-h1w9gbxk	45	10	oxygen	oxygen	NN
cord-017764-h1w9gbxk	45	11	,	,	,
cord-017764-h1w9gbxk	45	12	which	which	WDT
cord-017764-h1w9gbxk	45	13	is	be	VBZ
cord-017764-h1w9gbxk	45	14	a	a	DT
cord-017764-h1w9gbxk	45	15	diradical	diradical	JJ
cord-017764-h1w9gbxk	45	16	in	in	IN
cord-017764-h1w9gbxk	45	17	the	the	DT
cord-017764-h1w9gbxk	45	18	ground	ground	NN
cord-017764-h1w9gbxk	45	19	state	state	NN
cord-017764-h1w9gbxk	45	20	,	,	,
cord-017764-h1w9gbxk	45	21	would	would	MD
cord-017764-h1w9gbxk	45	22	lead	lead	VB
cord-017764-h1w9gbxk	45	23	to	to	IN
cord-017764-h1w9gbxk	45	24	the	the	DT
cord-017764-h1w9gbxk	45	25	C-5	C-5	NNP
cord-017764-h1w9gbxk	45	26	radical	radical	JJ
cord-017764-h1w9gbxk	45	27	11	11	CD
cord-017764-h1w9gbxk	45	28	that	that	WDT
cord-017764-h1w9gbxk	45	29	is	be	VBZ
cord-017764-h1w9gbxk	45	30	stabilized	stabilize	VBN
cord-017764-h1w9gbxk	45	31	in	in	IN
cord-017764-h1w9gbxk	45	32	a	a	DT
cord-017764-h1w9gbxk	45	33	classic	classic	JJ
cord-017764-h1w9gbxk	45	34	captodative	captodative	JJ
cord-017764-h1w9gbxk	45	35	fashion	fashion	NN
cord-017764-h1w9gbxk	45	36	by	by	IN
cord-017764-h1w9gbxk	45	37	the	the	DT
cord-017764-h1w9gbxk	45	38	adjacent	adjacent	JJ
cord-017764-h1w9gbxk	45	39	C¼O	C¼O	NNP
cord-017764-h1w9gbxk	45	40	moiety	moiety	NN
cord-017764-h1w9gbxk	45	41	,	,	,
cord-017764-h1w9gbxk	45	42	the	the	DT
cord-017764-h1w9gbxk	45	43	sulfur	sulfur	NN
cord-017764-h1w9gbxk	45	44	atom	atom	NN
cord-017764-h1w9gbxk	45	45	,	,	,
cord-017764-h1w9gbxk	45	46	and	and	CC
cord-017764-h1w9gbxk	45	47	the	the	DT
cord-017764-h1w9gbxk	45	48	phenyl	phenyl	NN
cord-017764-h1w9gbxk	45	49	substituent	substituent	NN
cord-017764-h1w9gbxk	45	50	[	[	-LRB-
cord-017764-h1w9gbxk	45	51	24	24	CD
cord-017764-h1w9gbxk	45	52	,	,	,
cord-017764-h1w9gbxk	45	53	25	25	CD
cord-017764-h1w9gbxk	45	54	]	]	-RRB-
cord-017764-h1w9gbxk	45	55	.	.	.
cord-017764-h1w9gbxk	46	1	Combination	combination	NN
cord-017764-h1w9gbxk	46	2	of	of	IN
cord-017764-h1w9gbxk	46	3	11	11	CD
cord-017764-h1w9gbxk	46	4	with	with	IN
cord-017764-h1w9gbxk	46	5	O	o	NN
cord-017764-h1w9gbxk	46	6	2	2	CD
cord-017764-h1w9gbxk	46	7	and	and	CC
cord-017764-h1w9gbxk	46	8	hydrogen	hydrogen	NN
cord-017764-h1w9gbxk	46	9	atom	atom	NN
cord-017764-h1w9gbxk	46	10	acquisition	acquisition	NN
cord-017764-h1w9gbxk	46	11	would	would	MD
cord-017764-h1w9gbxk	46	12	lead	lead	VB
cord-017764-h1w9gbxk	46	13	to	to	IN
cord-017764-h1w9gbxk	46	14	the	the	DT
cord-017764-h1w9gbxk	46	15	hydroperoxide	hydroperoxide	NN
cord-017764-h1w9gbxk	46	16	species	specie	VBZ
cord-017764-h1w9gbxk	46	17	12	12	CD
cord-017764-h1w9gbxk	46	18	which	which	WDT
cord-017764-h1w9gbxk	46	19	in	in	IN
cord-017764-h1w9gbxk	46	20	DMSO	DMSO	NNP
cord-017764-h1w9gbxk	46	21	would	would	MD
cord-017764-h1w9gbxk	46	22	be	be	VB
cord-017764-h1w9gbxk	46	23	reduced	reduce	VBN
cord-017764-h1w9gbxk	46	24	to	to	IN
cord-017764-h1w9gbxk	46	25	alcohol	alcohol	NN
cord-017764-h1w9gbxk	46	26	13	13	CD
cord-017764-h1w9gbxk	46	27	,	,	,
cord-017764-h1w9gbxk	46	28	an	an	DT
cord-017764-h1w9gbxk	46	29	unstable	unstable	JJ
cord-017764-h1w9gbxk	46	30	ring	ring	NN
cord-017764-h1w9gbxk	46	31	system	system	NN
cord-017764-h1w9gbxk	46	32	that	that	WDT
cord-017764-h1w9gbxk	46	33	would	would	MD
cord-017764-h1w9gbxk	46	34	be	be	VB
cord-017764-h1w9gbxk	46	35	expected	expect	VBN
cord-017764-h1w9gbxk	46	36	to	to	TO
cord-017764-h1w9gbxk	46	37	undergo	undergo	VB
cord-017764-h1w9gbxk	46	38	ring	ring	NN
cord-017764-h1w9gbxk	46	39	opening	opening	NN
cord-017764-h1w9gbxk	46	40	to	to	TO
cord-017764-h1w9gbxk	46	41	give	give	VB
cord-017764-h1w9gbxk	46	42	14	14	CD
cord-017764-h1w9gbxk	46	43	.	.	.
cord-017764-h1w9gbxk	47	1	Reclosure	reclosure	NN
cord-017764-h1w9gbxk	47	2	of	of	IN
cord-017764-h1w9gbxk	47	3	14	14	CD
cord-017764-h1w9gbxk	47	4	would	would	MD
cord-017764-h1w9gbxk	47	5	then	then	RB
cord-017764-h1w9gbxk	47	6	afford	afford	VB
cord-017764-h1w9gbxk	47	7	the	the	DT
cord-017764-h1w9gbxk	47	8	thiohydantoin	thiohydantoin	NNP
cord-017764-h1w9gbxk	47	9	15	15	CD
cord-017764-h1w9gbxk	47	10	,	,	,
cord-017764-h1w9gbxk	47	11	which	which	WDT
cord-017764-h1w9gbxk	47	12	had	have	VBD
cord-017764-h1w9gbxk	47	13	been	be	VBN
cord-017764-h1w9gbxk	47	14	isolated	isolate	VBN
cord-017764-h1w9gbxk	47	15	in	in	IN
cord-017764-h1w9gbxk	47	16	the	the	DT
cord-017764-h1w9gbxk	47	17	original	original	JJ
cord-017764-h1w9gbxk	47	18	DMSO	DMSO	NNP
cord-017764-h1w9gbxk	47	19	degradation	degradation	NN
cord-017764-h1w9gbxk	47	20	experiment	experiment	NN
cord-017764-h1w9gbxk	47	21	,	,	,
cord-017764-h1w9gbxk	47	22	while	while	IN
cord-017764-h1w9gbxk	47	23	hydrolytic	hydrolytic	JJ
cord-017764-h1w9gbxk	47	24	decomposition	decomposition	NN
cord-017764-h1w9gbxk	47	25	of	of	IN
cord-017764-h1w9gbxk	47	26	14	14	CD
cord-017764-h1w9gbxk	47	27	would	would	MD
cord-017764-h1w9gbxk	47	28	afford	afford	VB
cord-017764-h1w9gbxk	47	29	acid	acid	NN
cord-017764-h1w9gbxk	47	30	16	16	CD
cord-017764-h1w9gbxk	47	31	and	and	CC
cord-017764-h1w9gbxk	47	32	the	the	DT
cord-017764-h1w9gbxk	47	33	thiourea	thiourea	NN
cord-017764-h1w9gbxk	47	34	17	17	CD
cord-017764-h1w9gbxk	47	35	,	,	,
cord-017764-h1w9gbxk	47	36	the	the	DT
cord-017764-h1w9gbxk	47	37	latter	latter	JJ
cord-017764-h1w9gbxk	47	38	of	of	IN
cord-017764-h1w9gbxk	47	39	which	which	WDT
cord-017764-h1w9gbxk	47	40	had	have	VBD
cord-017764-h1w9gbxk	47	41	also	also	RB
cord-017764-h1w9gbxk	47	42	been	be	VBN
cord-017764-h1w9gbxk	47	43	isolated	isolate	VBN
cord-017764-h1w9gbxk	47	44	.	.	.
cord-017764-h1w9gbxk	48	1	However	however	RB
cord-017764-h1w9gbxk	48	2	,	,	,
cord-017764-h1w9gbxk	48	3	in	in	IN
cord-017764-h1w9gbxk	48	4	cell	cell	NN
cord-017764-h1w9gbxk	48	5	culture	culture	NN
cord-017764-h1w9gbxk	48	6	media	medium	NNS
cord-017764-h1w9gbxk	48	7	,	,	,
cord-017764-h1w9gbxk	48	8	the	the	DT
cord-017764-h1w9gbxk	48	9	stability	stability	NN
cord-017764-h1w9gbxk	48	10	of	of	IN
cord-017764-h1w9gbxk	48	11	radical	radical	JJ
cord-017764-h1w9gbxk	48	12	11	11	CD
cord-017764-h1w9gbxk	48	13	is	be	VBZ
cord-017764-h1w9gbxk	48	14	presumably	presumably	RB
cord-017764-h1w9gbxk	48	15	such	such	JJ
cord-017764-h1w9gbxk	48	16	that	that	DT
cord-017764-h1w9gbxk	48	17	dimerization	dimerization	NN
cord-017764-h1w9gbxk	48	18	can	can	MD
cord-017764-h1w9gbxk	48	19	occur	occur	VB
cord-017764-h1w9gbxk	48	20	,	,	,
cord-017764-h1w9gbxk	48	21	a	a	DT
cord-017764-h1w9gbxk	48	22	process	process	NN
cord-017764-h1w9gbxk	48	23	that	that	WDT
cord-017764-h1w9gbxk	48	24	may	may	MD
cord-017764-h1w9gbxk	48	25	well	well	RB
cord-017764-h1w9gbxk	48	26	be	be	VB
cord-017764-h1w9gbxk	48	27	facilitated	facilitate	VBN
cord-017764-h1w9gbxk	48	28	by	by	IN
cord-017764-h1w9gbxk	48	29	aggregative	aggregative	NNP
cord-017764-h1w9gbxk	48	30	association	association	NNP
cord-017764-h1w9gbxk	48	31	of	of	IN
cord-017764-h1w9gbxk	48	32	8	8	CD
cord-017764-h1w9gbxk	48	33	and/or	and/or	CC
cord-017764-h1w9gbxk	48	34	11	11	CD
cord-017764-h1w9gbxk	48	35	in	in	IN
cord-017764-h1w9gbxk	48	36	the	the	DT
cord-017764-h1w9gbxk	48	37	aqueous	aqueous	JJ
cord-017764-h1w9gbxk	48	38	medium	medium	NN
cord-017764-h1w9gbxk	48	39	.	.	.
cord-017764-h1w9gbxk	49	1	The	the	DT
cord-017764-h1w9gbxk	49	2	replicon	replicon	NN
cord-017764-h1w9gbxk	49	3	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	49	4	potency	potency	NN
cord-017764-h1w9gbxk	49	5	of	of	IN
cord-017764-h1w9gbxk	49	6	the	the	DT
cord-017764-h1w9gbxk	49	7	dimers	dimer	NNS
cord-017764-h1w9gbxk	49	8	18a	18a	NNS
cord-017764-h1w9gbxk	49	9	and	and	CC
cord-017764-h1w9gbxk	49	10	18b	18b	NNS
cord-017764-h1w9gbxk	49	11	was	be	VBD
cord-017764-h1w9gbxk	49	12	striking	strike	VBG
cord-017764-h1w9gbxk	49	13	,	,	,
cord-017764-h1w9gbxk	49	14	with	with	IN
cord-017764-h1w9gbxk	49	15	the	the	DT
cord-017764-h1w9gbxk	49	16	less	less	RBR
cord-017764-h1w9gbxk	49	17	mobile	mobile	JJ
cord-017764-h1w9gbxk	49	18	isomer	isomer	NN
cord-017764-h1w9gbxk	49	19	eluting	elute	VBG
cord-017764-h1w9gbxk	49	20	from	from	IN
cord-017764-h1w9gbxk	49	21	the	the	DT
cord-017764-h1w9gbxk	49	22	reversed	reversed	JJ
cord-017764-h1w9gbxk	49	23	phase	phase	NN
cord-017764-h1w9gbxk	49	24	chromatography	chromatography	NN
cord-017764-h1w9gbxk	49	25	column	column	NN
cord-017764-h1w9gbxk	49	26	exhibiting	exhibit	VBG
cord-017764-h1w9gbxk	49	27	an	an	DT
cord-017764-h1w9gbxk	49	28	EC	EC	NNP
cord-017764-h1w9gbxk	49	29	50	50	CD
cord-017764-h1w9gbxk	49	30	value	value	NN
cord-017764-h1w9gbxk	49	31	of	of	IN
cord-017764-h1w9gbxk	49	32	600	600	CD
cord-017764-h1w9gbxk	49	33	pM	pm	NN
cord-017764-h1w9gbxk	49	34	in	in	IN
cord-017764-h1w9gbxk	49	35	the	the	DT
cord-017764-h1w9gbxk	49	36	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	49	37	replicon	replicon	NN
cord-017764-h1w9gbxk	49	38	,	,	,
cord-017764-h1w9gbxk	49	39	while	while	IN
cord-017764-h1w9gbxk	49	40	the	the	DT
cord-017764-h1w9gbxk	49	41	thermodynamically	thermodynamically	RB
cord-017764-h1w9gbxk	49	42	more	more	RBR
cord-017764-h1w9gbxk	49	43	stable	stable	JJ
cord-017764-h1w9gbxk	49	44	and	and	CC
cord-017764-h1w9gbxk	49	45	chromatographically	chromatographically	RB
cord-017764-h1w9gbxk	49	46	more	more	JJR
cord-017764-h1w9gbxk	49	47	mobile	mobile	JJ
cord-017764-h1w9gbxk	49	48	isomer	isomer	NN
cord-017764-h1w9gbxk	49	49	was	be	VBD
cord-017764-h1w9gbxk	49	50	70-fold	70-fold	CD
cord-017764-h1w9gbxk	49	51	weaker	weak	JJR
cord-017764-h1w9gbxk	49	52	,	,	,
cord-017764-h1w9gbxk	49	53	EC	EC	NNP
cord-017764-h1w9gbxk	49	54	50	50	CD
cord-017764-h1w9gbxk	49	55	¼	¼	CD
cord-017764-h1w9gbxk	49	56	43	43	CD
cord-017764-h1w9gbxk	49	57	nM	nm	NN
cord-017764-h1w9gbxk	49	58	[	[	-LRB-
cord-017764-h1w9gbxk	49	59	15	15	CD
cord-017764-h1w9gbxk	49	60	,	,	,
cord-017764-h1w9gbxk	49	61	22	22	CD
cord-017764-h1w9gbxk	49	62	]	]	-RRB-
cord-017764-h1w9gbxk	49	63	.	.	.
cord-017764-h1w9gbxk	50	1	With	with	IN
cord-017764-h1w9gbxk	50	2	the	the	DT
cord-017764-h1w9gbxk	50	3	elucidation	elucidation	NN
cord-017764-h1w9gbxk	50	4	of	of	IN
cord-017764-h1w9gbxk	50	5	the	the	DT
cord-017764-h1w9gbxk	50	6	structures	structure	NNS
cord-017764-h1w9gbxk	50	7	of	of	IN
cord-017764-h1w9gbxk	50	8	18a	18a	NNS
cord-017764-h1w9gbxk	50	9	and	and	CC
cord-017764-h1w9gbxk	50	10	18b	18b	NNS
cord-017764-h1w9gbxk	50	11	,	,	,
cord-017764-h1w9gbxk	50	12	consideration	consideration	NN
cord-017764-h1w9gbxk	50	13	was	be	VBD
cord-017764-h1w9gbxk	50	14	given	give	VBN
cord-017764-h1w9gbxk	50	15	to	to	IN
cord-017764-h1w9gbxk	50	16	the	the	DT
cord-017764-h1w9gbxk	50	17	concept	concept	NN
cord-017764-h1w9gbxk	50	18	that	that	IN
cord-017764-h1w9gbxk	50	19	the	the	DT
cord-017764-h1w9gbxk	50	20	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	50	21	-	-	HYPH
cord-017764-h1w9gbxk	50	22	inhibiting	inhibit	VBG
cord-017764-h1w9gbxk	50	23	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	50	24	represented	represent	VBN
cord-017764-h1w9gbxk	50	25	by	by	IN
cord-017764-h1w9gbxk	50	26	these	these	DT
cord-017764-h1w9gbxk	50	27	dimers	dimer	NNS
cord-017764-h1w9gbxk	50	28	may	may	MD
cord-017764-h1w9gbxk	50	29	be	be	VB
cord-017764-h1w9gbxk	50	30	the	the	DT
cord-017764-h1w9gbxk	50	31	embedded	embed	VBN
cord-017764-h1w9gbxk	50	32	symmetrical	symmetrical	JJ
cord-017764-h1w9gbxk	50	33	bibenzyl	bibenzyl	JJ
cord-017764-h1w9gbxk	50	34	element	element	NN
cord-017764-h1w9gbxk	50	35	.	.	.
cord-017764-h1w9gbxk	51	1	This	this	DT
cord-017764-h1w9gbxk	51	2	notion	notion	NN
cord-017764-h1w9gbxk	51	3	was	be	VBD
cord-017764-h1w9gbxk	51	4	based	base	VBN
cord-017764-h1w9gbxk	51	5	on	on	IN
cord-017764-h1w9gbxk	51	6	an	an	DT
cord-017764-h1w9gbxk	51	7	appreciation	appreciation	NN
cord-017764-h1w9gbxk	51	8	of	of	IN
cord-017764-h1w9gbxk	51	9	the	the	DT
cord-017764-h1w9gbxk	51	10	precise	precise	JJ
cord-017764-h1w9gbxk	51	11	SARs	sar	NNS
cord-017764-h1w9gbxk	51	12	surrounding	surround	VBG
cord-017764-h1w9gbxk	51	13	the	the	DT
cord-017764-h1w9gbxk	51	14	amino	amino	NN
cord-017764-h1w9gbxk	51	15	acid	acid	NN
cord-017764-h1w9gbxk	51	16	moiety	moiety	NN
cord-017764-h1w9gbxk	51	17	in	in	IN
cord-017764-h1w9gbxk	51	18	contrast	contrast	NN
cord-017764-h1w9gbxk	51	19	to	to	IN
cord-017764-h1w9gbxk	51	20	the	the	DT
cord-017764-h1w9gbxk	51	21	relatively	relatively	RB
cord-017764-h1w9gbxk	51	22	more	more	RBR
cord-017764-h1w9gbxk	51	23	nebulous	nebulous	JJ
cord-017764-h1w9gbxk	51	24	effects	effect	NNS
cord-017764-h1w9gbxk	51	25	associated	associate	VBN
cord-017764-h1w9gbxk	51	26	with	with	IN
cord-017764-h1w9gbxk	51	27	structural	structural	JJ
cord-017764-h1w9gbxk	51	28	variation	variation	NN
cord-017764-h1w9gbxk	51	29	to	to	IN
cord-017764-h1w9gbxk	51	30	the	the	DT
cord-017764-h1w9gbxk	51	31	iminothiazolidinone	iminothiazolidinone	NNP
cord-017764-h1w9gbxk	51	32	substituents	substituent	NNS
cord-017764-h1w9gbxk	51	33	.	.	.
cord-017764-h1w9gbxk	52	1	Under	under	IN
cord-017764-h1w9gbxk	52	2	this	this	DT
cord-017764-h1w9gbxk	52	3	concept	concept	NN
cord-017764-h1w9gbxk	52	4	,	,	,
cord-017764-h1w9gbxk	52	5	the	the	DT
cord-017764-h1w9gbxk	52	6	iminothiazolidinone	iminothiazolidinone	NN
cord-017764-h1w9gbxk	52	7	ring	ring	NN
cord-017764-h1w9gbxk	52	8	system	system	NN
cord-017764-h1w9gbxk	52	9	of	of	IN
cord-017764-h1w9gbxk	52	10	2	2	CD
cord-017764-h1w9gbxk	52	11	was	be	VBD
cord-017764-h1w9gbxk	52	12	suggested	suggest	VBN
cord-017764-h1w9gbxk	52	13	to	to	TO
cord-017764-h1w9gbxk	52	14	act	act	VB
cord-017764-h1w9gbxk	52	15	as	as	IN
cord-017764-h1w9gbxk	52	16	a	a	DT
cord-017764-h1w9gbxk	52	17	scaffolding	scaffolding	NN
cord-017764-h1w9gbxk	52	18	element	element	NN
cord-017764-h1w9gbxk	52	19	by	by	IN
cord-017764-h1w9gbxk	52	20	which	which	WDT
cord-017764-h1w9gbxk	52	21	a	a	DT
cord-017764-h1w9gbxk	52	22	bivalent	bivalent	NN
cord-017764-h1w9gbxk	53	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	54	1	inhibitor	inhibitor	NNP
cord-017764-h1w9gbxk	54	2	pharmacophore	pharmacophore	NNP
cord-017764-h1w9gbxk	54	3	was	be	VBD
cord-017764-h1w9gbxk	54	4	convened	convene	VBN
cord-017764-h1w9gbxk	54	5	through	through	IN
cord-017764-h1w9gbxk	54	6	a	a	DT
cord-017764-h1w9gbxk	54	7	radical	radical	RB
cord-017764-h1w9gbxk	54	8	-	-	HYPH
cord-017764-h1w9gbxk	54	9	mediated	mediate	VBN
cord-017764-h1w9gbxk	54	10	dimerization	dimerization	NN
cord-017764-h1w9gbxk	54	11	process	process	NN
cord-017764-h1w9gbxk	54	12	[	[	-LRB-
cord-017764-h1w9gbxk	54	13	15	15	CD
cord-017764-h1w9gbxk	54	14	,	,	,
cord-017764-h1w9gbxk	54	15	22	22	CD
cord-017764-h1w9gbxk	54	16	]	]	-RRB-
cord-017764-h1w9gbxk	54	17	.	.	.
cord-017764-h1w9gbxk	55	1	This	this	DT
cord-017764-h1w9gbxk	55	2	hypothesis	hypothesis	NN
cord-017764-h1w9gbxk	55	3	was	be	VBD
cord-017764-h1w9gbxk	55	4	readily	readily	RB
cord-017764-h1w9gbxk	55	5	tested	test	VBN
cord-017764-h1w9gbxk	55	6	in	in	IN
cord-017764-h1w9gbxk	55	7	the	the	DT
cord-017764-h1w9gbxk	55	8	context	context	NN
cord-017764-h1w9gbxk	55	9	of	of	IN
cord-017764-h1w9gbxk	55	10	the	the	DT
cord-017764-h1w9gbxk	55	11	proline	proline	NN
cord-017764-h1w9gbxk	55	12	-	-	HYPH
cord-017764-h1w9gbxk	55	13	based	base	VBN
cord-017764-h1w9gbxk	55	14	chemotype	chemotype	NN
cord-017764-h1w9gbxk	55	15	,	,	,
cord-017764-h1w9gbxk	55	16	with	with	IN
cord-017764-h1w9gbxk	55	17	19	19	CD
cord-017764-h1w9gbxk	55	18	demonstrating	demonstrate	VBG
cord-017764-h1w9gbxk	55	19	an	an	DT
cord-017764-h1w9gbxk	55	20	EC	EC	NNP
cord-017764-h1w9gbxk	55	21	50	50	CD
cord-017764-h1w9gbxk	55	22	value	value	NN
cord-017764-h1w9gbxk	55	23	of	of	IN
cord-017764-h1w9gbxk	55	24	30	30	CD
cord-017764-h1w9gbxk	55	25	nM	nm	CD
cord-017764-h1w9gbxk	55	26	and	and	CC
cord-017764-h1w9gbxk	55	27	confirming	confirm	VBG
cord-017764-h1w9gbxk	55	28	the	the	DT
cord-017764-h1w9gbxk	55	29	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	55	30	proposal	proposal	NN
cord-017764-h1w9gbxk	55	31	.	.	.
cord-017764-h1w9gbxk	56	1	More	more	RBR
cord-017764-h1w9gbxk	56	2	interestingly	interestingly	RB
cord-017764-h1w9gbxk	56	3	,	,	,
cord-017764-h1w9gbxk	56	4	the	the	DT
cord-017764-h1w9gbxk	56	5	unsaturated	unsaturated	JJ
cord-017764-h1w9gbxk	56	6	synthetic	synthetic	JJ
cord-017764-h1w9gbxk	56	7	precursor	precursor	NN
cord-017764-h1w9gbxk	56	8	20	20	CD
cord-017764-h1w9gbxk	56	9	32	32	CD
cord-017764-h1w9gbxk	56	10	N.	n.	NN
cord-017764-h1w9gbxk	56	11	A.	a.	NN
cord-017764-h1w9gbxk	56	12	Meanwell	Meanwell	NNP
cord-017764-h1w9gbxk	56	13	and	and	CC
cord-017764-h1w9gbxk	56	14	M.	M.	NNP
cord-017764-h1w9gbxk	56	15	Belema	Belema	NNP
cord-017764-h1w9gbxk	56	16	was	be	VBD
cord-017764-h1w9gbxk	56	17	almost	almost	RB
cord-017764-h1w9gbxk	56	18	350-fold	350-fold	CD
cord-017764-h1w9gbxk	56	19	more	more	RBR
cord-017764-h1w9gbxk	56	20	potent	potent	JJ
cord-017764-h1w9gbxk	56	21	than	than	IN
cord-017764-h1w9gbxk	56	22	19	19	CD
cord-017764-h1w9gbxk	56	23	,	,	,
cord-017764-h1w9gbxk	56	24	EC	EC	NNP
cord-017764-h1w9gbxk	56	25	50	50	CD
cord-017764-h1w9gbxk	56	26	¼	¼	CD
cord-017764-h1w9gbxk	56	27	0.086	0.086	CD
cord-017764-h1w9gbxk	56	28	nM	nm	NN
cord-017764-h1w9gbxk	56	29	,	,	,
cord-017764-h1w9gbxk	56	30	providing	provide	VBG
cord-017764-h1w9gbxk	56	31	further	further	JJ
cord-017764-h1w9gbxk	56	32	insight	insight	NN
cord-017764-h1w9gbxk	56	33	into	into	IN
cord-017764-h1w9gbxk	56	34	the	the	DT
cord-017764-h1w9gbxk	56	35	topography	topography	NN
cord-017764-h1w9gbxk	56	36	of	of	IN
cord-017764-h1w9gbxk	56	37	the	the	DT
cord-017764-h1w9gbxk	56	38	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	56	39	-	-	HYPH
cord-017764-h1w9gbxk	56	40	inhibiting	inhibit	VBG
cord-017764-h1w9gbxk	56	41	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	56	42	.	.	.
cord-017764-h1w9gbxk	57	1	The	the	DT
cord-017764-h1w9gbxk	57	2	discovery	discovery	NN
cord-017764-h1w9gbxk	57	3	of	of	IN
cord-017764-h1w9gbxk	57	4	the	the	DT
cord-017764-h1w9gbxk	57	5	structurally	structurally	RB
cord-017764-h1w9gbxk	57	6	simpler	simple	JJR
cord-017764-h1w9gbxk	57	7	symmetrical	symmetrical	JJ
cord-017764-h1w9gbxk	57	8	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	57	9	represented	represent	VBN
cord-017764-h1w9gbxk	57	10	by	by	IN
cord-017764-h1w9gbxk	57	11	19	19	CD
cord-017764-h1w9gbxk	57	12	and	and	CC
cord-017764-h1w9gbxk	57	13	20	20	CD
cord-017764-h1w9gbxk	57	14	turned	turn	VBD
cord-017764-h1w9gbxk	57	15	out	out	RP
cord-017764-h1w9gbxk	57	16	to	to	TO
cord-017764-h1w9gbxk	57	17	be	be	VB
cord-017764-h1w9gbxk	57	18	prescient	prescient	JJ
cord-017764-h1w9gbxk	57	19	since	since	IN
cord-017764-h1w9gbxk	57	20	X	x	NN
cord-017764-h1w9gbxk	57	21	-	-	NN
cord-017764-h1w9gbxk	57	22	ray	ray	JJ
cord-017764-h1w9gbxk	57	23	crystallographic	crystallographic	JJ
cord-017764-h1w9gbxk	57	24	structure	structure	NN
cord-017764-h1w9gbxk	57	25	data	datum	NNS
cord-017764-h1w9gbxk	57	26	for	for	IN
cord-017764-h1w9gbxk	57	27	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	57	28	constructs	construct	NNS
cord-017764-h1w9gbxk	57	29	that	that	WDT
cord-017764-h1w9gbxk	57	30	were	be	VBD
cord-017764-h1w9gbxk	57	31	published	publish	VBN
cord-017764-h1w9gbxk	57	32	several	several	JJ
cord-017764-h1w9gbxk	57	33	years	year	NNS
cord-017764-h1w9gbxk	57	34	after	after	IN
cord-017764-h1w9gbxk	57	35	this	this	DT
cord-017764-h1w9gbxk	57	36	discovery	discovery	NN
cord-017764-h1w9gbxk	57	37	revealed	reveal	VBD
cord-017764-h1w9gbxk	57	38	a	a	DT
cord-017764-h1w9gbxk	57	39	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	57	40	,	,	,
cord-017764-h1w9gbxk	57	41	C2-symmetric	c2-symmetric	JJ
cord-017764-h1w9gbxk	57	42	protein	protein	NN
cord-017764-h1w9gbxk	57	43	complex	complex	NN
cord-017764-h1w9gbxk	57	44	[	[	-LRB-
cord-017764-h1w9gbxk	57	45	26	26	CD
cord-017764-h1w9gbxk	57	46	]	]	-RRB-
cord-017764-h1w9gbxk	58	1	[	[	-LRB-
cord-017764-h1w9gbxk	58	2	27	27	CD
cord-017764-h1w9gbxk	58	3	]	]	-RRB-
cord-017764-h1w9gbxk	58	4	[	[	-LRB-
cord-017764-h1w9gbxk	58	5	28	28	CD
cord-017764-h1w9gbxk	58	6	]	]	-RRB-
cord-017764-h1w9gbxk	58	7	.	.	.
cord-017764-h1w9gbxk	59	1	Of	of	IN
cord-017764-h1w9gbxk	59	2	note	note	NN
cord-017764-h1w9gbxk	59	3	,	,	,
cord-017764-h1w9gbxk	59	4	this	this	DT
cord-017764-h1w9gbxk	59	5	structure	structure	NN
cord-017764-h1w9gbxk	59	6	was	be	VBD
cord-017764-h1w9gbxk	59	7	determined	determine	VBN
cord-017764-h1w9gbxk	59	8	using	use	VBG
cord-017764-h1w9gbxk	59	9	a	a	DT
cord-017764-h1w9gbxk	59	10	protein	protein	NN
cord-017764-h1w9gbxk	59	11	construct	construct	NN
cord-017764-h1w9gbxk	59	12	lacking	lack	VBG
cord-017764-h1w9gbxk	59	13	the	the	DT
cord-017764-h1w9gbxk	59	14	membrane	membrane	NN
cord-017764-h1w9gbxk	59	15	-	-	HYPH
cord-017764-h1w9gbxk	59	16	associating	associate	VBG
cord-017764-h1w9gbxk	59	17	amino	amino	NN
cord-017764-h1w9gbxk	59	18	terminus	terminus	NN
cord-017764-h1w9gbxk	60	1	but	but	CC
cord-017764-h1w9gbxk	60	2	,	,	,
cord-017764-h1w9gbxk	60	3	nevertheless	nevertheless	RB
cord-017764-h1w9gbxk	60	4	,	,	,
cord-017764-h1w9gbxk	60	5	containing	contain	VBG
cord-017764-h1w9gbxk	60	6	some	some	DT
cord-017764-h1w9gbxk	60	7	of	of	IN
cord-017764-h1w9gbxk	60	8	the	the	DT
cord-017764-h1w9gbxk	60	9	key	key	JJ
cord-017764-h1w9gbxk	60	10	elements	element	NNS
cord-017764-h1w9gbxk	60	11	of	of	IN
cord-017764-h1w9gbxk	60	12	the	the	DT
cord-017764-h1w9gbxk	60	13	anticipated	anticipate	VBN
cord-017764-h1w9gbxk	60	14	binding	binding	NN
cord-017764-h1w9gbxk	60	15	site	site	NN
cord-017764-h1w9gbxk	60	16	for	for	IN
cord-017764-h1w9gbxk	60	17	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	60	18	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	60	19	based	base	VBN
cord-017764-h1w9gbxk	60	20	on	on	IN
cord-017764-h1w9gbxk	60	21	the	the	DT
cord-017764-h1w9gbxk	60	22	location	location	NN
cord-017764-h1w9gbxk	60	23	of	of	IN
cord-017764-h1w9gbxk	60	24	resistance	resistance	NN
cord-017764-h1w9gbxk	60	25	mutations	mutation	NNS
cord-017764-h1w9gbxk	60	26	.	.	.
cord-017764-h1w9gbxk	61	1	The	the	DT
cord-017764-h1w9gbxk	61	2	availability	availability	NN
cord-017764-h1w9gbxk	61	3	of	of	IN
cord-017764-h1w9gbxk	61	4	a	a	DT
cord-017764-h1w9gbxk	61	5	structure	structure	NN
cord-017764-h1w9gbxk	61	6	of	of	IN
cord-017764-h1w9gbxk	61	7	the	the	DT
cord-017764-h1w9gbxk	61	8	amino	amino	NN
cord-017764-h1w9gbxk	61	9	terminus	terminus	NN
cord-017764-h1w9gbxk	61	10	of	of	IN
cord-017764-h1w9gbxk	61	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	61	12	,	,	,
cord-017764-h1w9gbxk	61	13	acquired	acquire	VBN
cord-017764-h1w9gbxk	61	14	by	by	IN
cord-017764-h1w9gbxk	61	15	NMR	NMR	NNP
cord-017764-h1w9gbxk	61	16	methodology	methodology	NN
cord-017764-h1w9gbxk	61	17	,	,	,
cord-017764-h1w9gbxk	61	18	facilitated	facilitate	VBD
cord-017764-h1w9gbxk	61	19	the	the	DT
cord-017764-h1w9gbxk	61	20	construction	construction	NN
cord-017764-h1w9gbxk	61	21	of	of	IN
cord-017764-h1w9gbxk	61	22	models	model	NNS
cord-017764-h1w9gbxk	61	23	of	of	IN
cord-017764-h1w9gbxk	61	24	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	61	25	that	that	IN
cord-017764-h1w9gbxk	61	26	,	,	,
cord-017764-h1w9gbxk	61	27	when	when	WRB
cord-017764-h1w9gbxk	61	28	combined	combine	VBN
cord-017764-h1w9gbxk	61	29	with	with	IN
cord-017764-h1w9gbxk	61	30	the	the	DT
cord-017764-h1w9gbxk	61	31	resistance	resistance	NN
cord-017764-h1w9gbxk	61	32	mutation	mutation	NN
cord-017764-h1w9gbxk	61	33	data	datum	NNS
cord-017764-h1w9gbxk	61	34	,	,	,
cord-017764-h1w9gbxk	61	35	suggested	suggest	VBD
cord-017764-h1w9gbxk	61	36	that	that	IN
cord-017764-h1w9gbxk	61	37	these	these	DT
cord-017764-h1w9gbxk	61	38	compounds	compound	NNS
cord-017764-h1w9gbxk	61	39	bound	bind	VBN
cord-017764-h1w9gbxk	61	40	across	across	IN
cord-017764-h1w9gbxk	61	41	the	the	DT
cord-017764-h1w9gbxk	61	42	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	61	43	dimer	dimer	NN
cord-017764-h1w9gbxk	61	44	interface	interface	NN
cord-017764-h1w9gbxk	61	45	at	at	IN
cord-017764-h1w9gbxk	61	46	a	a	DT
cord-017764-h1w9gbxk	61	47	site	site	NN
cord-017764-h1w9gbxk	61	48	residing	reside	VBG
cord-017764-h1w9gbxk	61	49	between	between	IN
cord-017764-h1w9gbxk	61	50	the	the	DT
cord-017764-h1w9gbxk	61	51	membrane	membrane	NN
cord-017764-h1w9gbxk	61	52	and	and	CC
cord-017764-h1w9gbxk	61	53	the	the	DT
cord-017764-h1w9gbxk	61	54	core	core	NN
cord-017764-h1w9gbxk	61	55	of	of	IN
cord-017764-h1w9gbxk	61	56	the	the	DT
cord-017764-h1w9gbxk	61	57	protein	protein	NN
cord-017764-h1w9gbxk	61	58	.	.	.
cord-017764-h1w9gbxk	62	1	Dimerization	Dimerization	NNP
cord-017764-h1w9gbxk	62	2	of	of	IN
cord-017764-h1w9gbxk	62	3	the	the	DT
cord-017764-h1w9gbxk	62	4	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	62	5	protein	protein	NN
cord-017764-h1w9gbxk	62	6	in	in	IN
cord-017764-h1w9gbxk	62	7	cells	cell	NNS
cord-017764-h1w9gbxk	62	8	was	be	VBD
cord-017764-h1w9gbxk	62	9	subsequently	subsequently	RB
cord-017764-h1w9gbxk	62	10	confirmed	confirm	VBN
cord-017764-h1w9gbxk	62	11	as	as	IN
cord-017764-h1w9gbxk	62	12	was	be	VBD
cord-017764-h1w9gbxk	62	13	association	association	NN
cord-017764-h1w9gbxk	62	14	of	of	IN
cord-017764-h1w9gbxk	62	15	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	62	16	with	with	IN
cord-017764-h1w9gbxk	62	17	RNA	RNA	NNP
cord-017764-h1w9gbxk	62	18	,	,	,
cord-017764-h1w9gbxk	62	19	a	a	DT
cord-017764-h1w9gbxk	62	20	prediction	prediction	NN
cord-017764-h1w9gbxk	62	21	from	from	IN
cord-017764-h1w9gbxk	62	22	the	the	DT
cord-017764-h1w9gbxk	62	23	X	x	NN
cord-017764-h1w9gbxk	62	24	-	-	NN
cord-017764-h1w9gbxk	62	25	ray	ray	NN
cord-017764-h1w9gbxk	62	26	data	datum	NNS
cord-017764-h1w9gbxk	62	27	based	base	VBN
cord-017764-h1w9gbxk	62	28	on	on	IN
cord-017764-h1w9gbxk	62	29	the	the	DT
cord-017764-h1w9gbxk	62	30	preponderance	preponderance	NN
cord-017764-h1w9gbxk	62	31	of	of	IN
cord-017764-h1w9gbxk	62	32	basic	basic	JJ
cord-017764-h1w9gbxk	62	33	amino	amino	JJ
cord-017764-h1w9gbxk	62	34	acids	acid	NNS
cord-017764-h1w9gbxk	62	35	lining	line	VBG
cord-017764-h1w9gbxk	62	36	the	the	DT
cord-017764-h1w9gbxk	62	37	inner	inner	JJ
cord-017764-h1w9gbxk	62	38	surface	surface	NN
cord-017764-h1w9gbxk	62	39	of	of	IN
cord-017764-h1w9gbxk	62	40	the	the	DT
cord-017764-h1w9gbxk	62	41	U	u	NN
cord-017764-h1w9gbxk	62	42	-	-	HYPH
cord-017764-h1w9gbxk	62	43	shaped	shape	VBN
cord-017764-h1w9gbxk	62	44	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	62	45	form	form	NN
cord-017764-h1w9gbxk	62	46	of	of	IN
cord-017764-h1w9gbxk	62	47	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	62	48	in	in	IN
cord-017764-h1w9gbxk	62	49	the	the	DT
cord-017764-h1w9gbxk	62	50	solid	solid	JJ
cord-017764-h1w9gbxk	62	51	state	state	NN
cord-017764-h1w9gbxk	62	52	[	[	-LRB-
cord-017764-h1w9gbxk	62	53	29	29	CD
cord-017764-h1w9gbxk	62	54	]	]	-RRB-
cord-017764-h1w9gbxk	62	55	[	[	-LRB-
cord-017764-h1w9gbxk	62	56	30	30	CD
cord-017764-h1w9gbxk	62	57	]	]	-RRB-
cord-017764-h1w9gbxk	62	58	[	[	-LRB-
cord-017764-h1w9gbxk	62	59	31	31	CD
cord-017764-h1w9gbxk	62	60	]	]	-RRB-
cord-017764-h1w9gbxk	62	61	[	[	-LRB-
cord-017764-h1w9gbxk	62	62	32	32	CD
cord-017764-h1w9gbxk	62	63	]	]	-RRB-
cord-017764-h1w9gbxk	62	64	.	.	.
cord-017764-h1w9gbxk	63	1	While	while	IN
cord-017764-h1w9gbxk	63	2	the	the	DT
cord-017764-h1w9gbxk	63	3	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	63	4	activity	activity	NN
cord-017764-h1w9gbxk	63	5	of	of	IN
cord-017764-h1w9gbxk	63	6	20	20	CD
cord-017764-h1w9gbxk	63	7	was	be	VBD
cord-017764-h1w9gbxk	63	8	attractive	attractive	JJ
cord-017764-h1w9gbxk	63	9	,	,	,
cord-017764-h1w9gbxk	63	10	there	there	EX
cord-017764-h1w9gbxk	63	11	were	be	VBD
cord-017764-h1w9gbxk	63	12	concerns	concern	NNS
cord-017764-h1w9gbxk	63	13	around	around	IN
cord-017764-h1w9gbxk	63	14	elements	element	NNS
cord-017764-h1w9gbxk	63	15	embedded	embed	VBN
cord-017764-h1w9gbxk	63	16	within	within	IN
cord-017764-h1w9gbxk	63	17	the	the	DT
cord-017764-h1w9gbxk	63	18	structure	structure	NN
cord-017764-h1w9gbxk	63	19	,	,	,
cord-017764-h1w9gbxk	63	20	with	with	IN
cord-017764-h1w9gbxk	63	21	the	the	DT
cord-017764-h1w9gbxk	63	22	olefin	olefin	NN
cord-017764-h1w9gbxk	63	23	observed	observe	VBN
cord-017764-h1w9gbxk	63	24	to	to	TO
cord-017764-h1w9gbxk	63	25	be	be	VB
cord-017764-h1w9gbxk	63	26	configurationally	configurationally	RB
cord-017764-h1w9gbxk	63	27	unstable	unstable	JJ
cord-017764-h1w9gbxk	63	28	in	in	IN
cord-017764-h1w9gbxk	63	29	some	some	DT
cord-017764-h1w9gbxk	63	30	analogues	analogue	NNS
cord-017764-h1w9gbxk	63	31	,	,	,
cord-017764-h1w9gbxk	63	32	while	while	IN
cord-017764-h1w9gbxk	63	33	the	the	DT
cord-017764-h1w9gbxk	63	34	potential	potential	NN
cord-017764-h1w9gbxk	63	35	for	for	IN
cord-017764-h1w9gbxk	63	36	release	release	NN
cord-017764-h1w9gbxk	63	37	of	of	IN
cord-017764-h1w9gbxk	63	38	one	one	CD
cord-017764-h1w9gbxk	63	39	or	or	CC
cord-017764-h1w9gbxk	63	40	both	both	DT
cord-017764-h1w9gbxk	63	41	aniline	aniline	NN
cord-017764-h1w9gbxk	63	42	moieties	moiety	NNS
cord-017764-h1w9gbxk	63	43	after	after	IN
cord-017764-h1w9gbxk	63	44	the	the	DT
cord-017764-h1w9gbxk	63	45	action	action	NN
cord-017764-h1w9gbxk	63	46	of	of	IN
cord-017764-h1w9gbxk	63	47	an	an	DT
cord-017764-h1w9gbxk	63	48	amidase	amidase	NN
cord-017764-h1w9gbxk	63	49	or	or	CC
cord-017764-h1w9gbxk	63	50	protease	protease	NN
cord-017764-h1w9gbxk	63	51	in	in	IN
cord-017764-h1w9gbxk	63	52	vivo	vivo	NNP
cord-017764-h1w9gbxk	63	53	raised	raise	VBD
cord-017764-h1w9gbxk	63	54	the	the	DT
cord-017764-h1w9gbxk	63	55	specter	specter	NN
cord-017764-h1w9gbxk	63	56	of	of	IN
cord-017764-h1w9gbxk	63	57	toxicity	toxicity	NN
cord-017764-h1w9gbxk	63	58	.	.	.
cord-017764-h1w9gbxk	64	1	However	however	RB
cord-017764-h1w9gbxk	64	2	,	,	,
cord-017764-h1w9gbxk	64	3	a	a	DT
cord-017764-h1w9gbxk	64	4	considerably	considerably	RB
cord-017764-h1w9gbxk	64	5	more	more	RBR
cord-017764-h1w9gbxk	64	6	challenging	challenging	JJ
cord-017764-h1w9gbxk	64	7	problem	problem	NN
cord-017764-h1w9gbxk	64	8	arose	arise	VBD
cord-017764-h1w9gbxk	64	9	when	when	WRB
cord-017764-h1w9gbxk	64	10	20	20	CD
cord-017764-h1w9gbxk	64	11	was	be	VBD
cord-017764-h1w9gbxk	64	12	evaluated	evaluate	VBN
cord-017764-h1w9gbxk	64	13	in	in	IN
cord-017764-h1w9gbxk	64	14	a	a	DT
cord-017764-h1w9gbxk	64	15	newly	newly	RB
cord-017764-h1w9gbxk	64	16	developed	develop	VBN
cord-017764-h1w9gbxk	64	17	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	64	18	replicon	replicon	NNP
cord-017764-h1w9gbxk	64	19	where	where	WRB
cord-017764-h1w9gbxk	64	20	the	the	DT
cord-017764-h1w9gbxk	64	21	compound	compound	NN
cord-017764-h1w9gbxk	64	22	was	be	VBD
cord-017764-h1w9gbxk	64	23	found	find	VBN
cord-017764-h1w9gbxk	64	24	to	to	TO
cord-017764-h1w9gbxk	64	25	be	be	VB
cord-017764-h1w9gbxk	64	26	poorly	poorly	RB
cord-017764-h1w9gbxk	64	27	active	active	JJ
cord-017764-h1w9gbxk	64	28	,	,	,
cord-017764-h1w9gbxk	64	29	with	with	IN
cord-017764-h1w9gbxk	64	30	an	an	DT
cord-017764-h1w9gbxk	64	31	EC	EC	NNP
cord-017764-h1w9gbxk	64	32	50	50	CD
cord-017764-h1w9gbxk	64	33	value	value	NN
cord-017764-h1w9gbxk	64	34	that	that	WDT
cord-017764-h1w9gbxk	64	35	was	be	VBD
cord-017764-h1w9gbxk	64	36	in	in	IN
cord-017764-h1w9gbxk	64	37	excess	excess	NN
cord-017764-h1w9gbxk	64	38	of	of	IN
cord-017764-h1w9gbxk	64	39	10	10	CD
cord-017764-h1w9gbxk	65	1	μM.	μM.	NNP
cord-017764-h1w9gbxk	65	2	The	the	DT
cord-017764-h1w9gbxk	65	3	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	65	4	strain	strain	NN
cord-017764-h1w9gbxk	65	5	of	of	IN
cord-017764-h1w9gbxk	65	6	HCV	HCV	NNP
cord-017764-h1w9gbxk	65	7	is	be	VBZ
cord-017764-h1w9gbxk	65	8	clinically	clinically	RB
cord-017764-h1w9gbxk	65	9	relevant	relevant	JJ
cord-017764-h1w9gbxk	65	10	,	,	,
cord-017764-h1w9gbxk	65	11	with	with	IN
cord-017764-h1w9gbxk	65	12	prevalence	prevalence	NN
cord-017764-h1w9gbxk	65	13	that	that	WDT
cord-017764-h1w9gbxk	65	14	varies	vary	VBZ
cord-017764-h1w9gbxk	65	15	across	across	IN
cord-017764-h1w9gbxk	65	16	the	the	DT
cord-017764-h1w9gbxk	65	17	globe	globe	NN
cord-017764-h1w9gbxk	65	18	;	;	:
cord-017764-h1w9gbxk	65	19	consequently	consequently	RB
cord-017764-h1w9gbxk	65	20	,	,	,
cord-017764-h1w9gbxk	65	21	securing	secure	VBG
cord-017764-h1w9gbxk	65	22	activity	activity	NN
cord-017764-h1w9gbxk	65	23	toward	toward	IN
cord-017764-h1w9gbxk	65	24	this	this	DT
cord-017764-h1w9gbxk	65	25	genotype	genotype	NN
cord-017764-h1w9gbxk	65	26	was	be	VBD
cord-017764-h1w9gbxk	65	27	considered	consider	VBN
cord-017764-h1w9gbxk	65	28	to	to	TO
cord-017764-h1w9gbxk	65	29	be	be	VB
cord-017764-h1w9gbxk	65	30	a	a	DT
cord-017764-h1w9gbxk	65	31	critical	critical	JJ
cord-017764-h1w9gbxk	65	32	objective	objective	NN
cord-017764-h1w9gbxk	65	33	.	.	.
cord-017764-h1w9gbxk	66	1	Enhancing	enhance	VBG
cord-017764-h1w9gbxk	66	2	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	66	3	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	66	4	activity	activity	NN
cord-017764-h1w9gbxk	66	5	became	become	VBD
cord-017764-h1w9gbxk	66	6	the	the	DT
cord-017764-h1w9gbxk	66	7	immediate	immediate	JJ
cord-017764-h1w9gbxk	66	8	focus	focus	NN
cord-017764-h1w9gbxk	66	9	of	of	IN
cord-017764-h1w9gbxk	66	10	further	further	JJ
cord-017764-h1w9gbxk	66	11	study	study	NN
cord-017764-h1w9gbxk	66	12	,	,	,
cord-017764-h1w9gbxk	66	13	and	and	CC
cord-017764-h1w9gbxk	66	14	the	the	DT
cord-017764-h1w9gbxk	66	15	approach	approach	NN
cord-017764-h1w9gbxk	66	16	adopted	adopt	VBD
cord-017764-h1w9gbxk	66	17	,	,	,
cord-017764-h1w9gbxk	66	18	while	while	IN
cord-017764-h1w9gbxk	66	19	primarily	primarily	RB
cord-017764-h1w9gbxk	66	20	directed	direct	VBN
cord-017764-h1w9gbxk	66	21	toward	toward	IN
cord-017764-h1w9gbxk	66	22	the	the	DT
cord-017764-h1w9gbxk	66	23	peripheral	peripheral	JJ
cord-017764-h1w9gbxk	66	24	elements	element	NNS
cord-017764-h1w9gbxk	66	25	,	,	,
cord-017764-h1w9gbxk	66	26	was	be	VBD
cord-017764-h1w9gbxk	66	27	broad	broad	RB
cord-017764-h1w9gbxk	66	28	-	-	HYPH
cord-017764-h1w9gbxk	66	29	based	base	VBN
cord-017764-h1w9gbxk	66	30	in	in	IN
cord-017764-h1w9gbxk	66	31	prosecution	prosecution	NN
cord-017764-h1w9gbxk	66	32	.	.	.
cord-017764-h1w9gbxk	67	1	Modifications	modification	NNS
cord-017764-h1w9gbxk	67	2	to	to	IN
cord-017764-h1w9gbxk	67	3	all	all	DT
cord-017764-h1w9gbxk	67	4	facets	facet	NNS
cord-017764-h1w9gbxk	67	5	of	of	IN
cord-017764-h1w9gbxk	67	6	the	the	DT
cord-017764-h1w9gbxk	67	7	molecule	molecule	NN
cord-017764-h1w9gbxk	67	8	were	be	VBD
cord-017764-h1w9gbxk	67	9	explored	explore	VBN
cord-017764-h1w9gbxk	67	10	,	,	,
cord-017764-h1w9gbxk	67	11	some	some	DT
cord-017764-h1w9gbxk	67	12	of	of	IN
cord-017764-h1w9gbxk	67	13	which	which	WDT
cord-017764-h1w9gbxk	67	14	were	be	VBD
cord-017764-h1w9gbxk	67	15	also	also	RB
cord-017764-h1w9gbxk	67	16	directed	direct	VBN
cord-017764-h1w9gbxk	67	17	toward	toward	IN
cord-017764-h1w9gbxk	67	18	simultaneously	simultaneously	RB
cord-017764-h1w9gbxk	67	19	addressing	address	VBG
cord-017764-h1w9gbxk	67	20	the	the	DT
cord-017764-h1w9gbxk	67	21	structural	structural	JJ
cord-017764-h1w9gbxk	67	22	liabilities	liability	NNS
cord-017764-h1w9gbxk	67	23	highlighted	highlight	VBN
cord-017764-h1w9gbxk	67	24	above	above	RB
cord-017764-h1w9gbxk	67	25	.	.	.
cord-017764-h1w9gbxk	68	1	However	however	RB
cord-017764-h1w9gbxk	68	2	,	,	,
cord-017764-h1w9gbxk	68	3	as	as	IN
cord-017764-h1w9gbxk	68	4	described	describe	VBN
cord-017764-h1w9gbxk	68	5	below	below	RB
cord-017764-h1w9gbxk	68	6	,	,	,
cord-017764-h1w9gbxk	68	7	introducing	introduce	VBG
cord-017764-h1w9gbxk	68	8	and	and	CC
cord-017764-h1w9gbxk	68	9	retaining	retain	VBG
cord-017764-h1w9gbxk	68	10	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	68	11	coverage	coverage	NN
cord-017764-h1w9gbxk	68	12	while	while	IN
cord-017764-h1w9gbxk	68	13	optimizing	optimize	VBG
cord-017764-h1w9gbxk	68	14	ADME	ADME	NNP
cord-017764-h1w9gbxk	68	15	properties	property	NNS
cord-017764-h1w9gbxk	68	16	would	would	MD
cord-017764-h1w9gbxk	68	17	end	end	VB
cord-017764-h1w9gbxk	68	18	up	up	RP
cord-017764-h1w9gbxk	68	19	posing	pose	VBG
cord-017764-h1w9gbxk	68	20	a	a	DT
cord-017764-h1w9gbxk	68	21	considerable	considerable	JJ
cord-017764-h1w9gbxk	68	22	challenge	challenge	NN
cord-017764-h1w9gbxk	68	23	.	.	.
cord-017764-h1w9gbxk	69	1	While	while	IN
cord-017764-h1w9gbxk	69	2	deeper	deep	JJR
cord-017764-h1w9gbxk	69	3	insight	insight	NN
cord-017764-h1w9gbxk	69	4	into	into	IN
cord-017764-h1w9gbxk	69	5	SARs	SARs	NNP
cord-017764-h1w9gbxk	69	6	for	for	IN
cord-017764-h1w9gbxk	69	7	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	69	8	inhibition	inhibition	NN
cord-017764-h1w9gbxk	69	9	emerged	emerge	VBD
cord-017764-h1w9gbxk	69	10	from	from	IN
cord-017764-h1w9gbxk	69	11	the	the	DT
cord-017764-h1w9gbxk	69	12	initial	initial	JJ
cord-017764-h1w9gbxk	69	13	phases	phase	NNS
cord-017764-h1w9gbxk	69	14	of	of	IN
cord-017764-h1w9gbxk	69	15	this	this	DT
cord-017764-h1w9gbxk	69	16	effort	effort	NN
cord-017764-h1w9gbxk	69	17	,	,	,
cord-017764-h1w9gbxk	69	18	only	only	RB
cord-017764-h1w9gbxk	69	19	a	a	DT
cord-017764-h1w9gbxk	69	20	small	small	JJ
cord-017764-h1w9gbxk	69	21	number	number	NN
cord-017764-h1w9gbxk	69	22	of	of	IN
cord-017764-h1w9gbxk	69	23	compounds	compound	NNS
cord-017764-h1w9gbxk	69	24	were	be	VBD
cord-017764-h1w9gbxk	69	25	identified	identify	VBN
cord-017764-h1w9gbxk	69	26	that	that	IN
cord-017764-h1w9gbxk	69	27	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	69	28	modest	modest	JJ
cord-017764-h1w9gbxk	69	29	but	but	CC
cord-017764-h1w9gbxk	69	30	reproducible	reproducible	JJ
cord-017764-h1w9gbxk	69	31	GT-1a	gt-1a	NN
cord-017764-h1w9gbxk	69	32	inhibition	inhibition	NN
cord-017764-h1w9gbxk	69	33	.	.	.
cord-017764-h1w9gbxk	70	1	Among	among	IN
cord-017764-h1w9gbxk	70	2	these	these	DT
cord-017764-h1w9gbxk	70	3	were	be	VBD
cord-017764-h1w9gbxk	70	4	the	the	DT
cord-017764-h1w9gbxk	70	5	oxazole	oxazole	NN
cord-017764-h1w9gbxk	70	6	21	21	CD
cord-017764-h1w9gbxk	70	7	and	and	CC
cord-017764-h1w9gbxk	70	8	the	the	DT
cord-017764-h1w9gbxk	70	9	substituted	substitute	VBN
cord-017764-h1w9gbxk	70	10	proline	proline	NN
cord-017764-h1w9gbxk	70	11	derivative	derivative	NNP
cord-017764-h1w9gbxk	70	12	22	22	CD
cord-017764-h1w9gbxk	70	13	,	,	,
cord-017764-h1w9gbxk	70	14	both	both	DT
cord-017764-h1w9gbxk	70	15	of	of	IN
cord-017764-h1w9gbxk	70	16	which	which	WDT
cord-017764-h1w9gbxk	70	17	were	be	VBD
cord-017764-h1w9gbxk	70	18	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	70	19	in	in	IN
cord-017764-h1w9gbxk	70	20	the	the	DT
cord-017764-h1w9gbxk	70	21	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	70	22	replicon	replicon	NN
cord-017764-h1w9gbxk	70	23	with	with	IN
cord-017764-h1w9gbxk	70	24	EC	EC	NNP
cord-017764-h1w9gbxk	70	25	50	50	CD
cord-017764-h1w9gbxk	70	26	values	value	NNS
cord-017764-h1w9gbxk	70	27	of	of	IN
cord-017764-h1w9gbxk	70	28	less	less	JJR
cord-017764-h1w9gbxk	70	29	than	than	IN
cord-017764-h1w9gbxk	70	30	1	1	CD
cord-017764-h1w9gbxk	71	1	μM	μM	NNP
cord-017764-h1w9gbxk	71	2	[	[	-LRB-
cord-017764-h1w9gbxk	71	3	33	33	CD
cord-017764-h1w9gbxk	71	4	]	]	-RRB-
cord-017764-h1w9gbxk	71	5	.	.	.
cord-017764-h1w9gbxk	72	1	However	however	RB
cord-017764-h1w9gbxk	72	2	,	,	,
cord-017764-h1w9gbxk	72	3	attempts	attempt	VBZ
cord-017764-h1w9gbxk	72	4	to	to	TO
cord-017764-h1w9gbxk	72	5	optimize	optimize	VB
cord-017764-h1w9gbxk	72	6	these	these	DT
cord-017764-h1w9gbxk	72	7	molecules	molecule	NNS
cord-017764-h1w9gbxk	72	8	were	be	VBD
cord-017764-h1w9gbxk	72	9	unproductive	unproductive	JJ
cord-017764-h1w9gbxk	72	10	,	,	,
cord-017764-h1w9gbxk	72	11	in	in	IN
cord-017764-h1w9gbxk	72	12	each	each	DT
cord-017764-h1w9gbxk	72	13	case	case	NN
cord-017764-h1w9gbxk	72	14	leading	lead	VBG
cord-017764-h1w9gbxk	72	15	to	to	IN
cord-017764-h1w9gbxk	72	16	SAR	SAR	NNP
cord-017764-h1w9gbxk	72	17	cul	cul	NNP
cord-017764-h1w9gbxk	72	18	-	-	HYPH
cord-017764-h1w9gbxk	72	19	de	de	JJ
cord-017764-h1w9gbxk	72	20	-	-	HYPH
cord-017764-h1w9gbxk	72	21	sacs	sac	NNS
cord-017764-h1w9gbxk	72	22	.	.	.
cord-017764-h1w9gbxk	73	1	As	as	IN
cord-017764-h1w9gbxk	73	2	the	the	DT
cord-017764-h1w9gbxk	73	3	studies	study	NNS
cord-017764-h1w9gbxk	73	4	progressed	progress	VBD
cord-017764-h1w9gbxk	73	5	,	,	,
cord-017764-h1w9gbxk	73	6	the	the	DT
cord-017764-h1w9gbxk	73	7	2-ethyl	2-ethyl	CD
cord-017764-h1w9gbxk	73	8	-	-	HYPH
cord-017764-h1w9gbxk	73	9	substituted	substitute	VBN
cord-017764-h1w9gbxk	73	10	benzamide	benzamide	NNP
cord-017764-h1w9gbxk	73	11	derivative	derivative	NNP
cord-017764-h1w9gbxk	73	12	23	23	CD
cord-017764-h1w9gbxk	73	13	and	and	CC
cord-017764-h1w9gbxk	73	14	its	-PRON-	PRP$
cord-017764-h1w9gbxk	73	15	unsaturated	unsaturated	JJ
cord-017764-h1w9gbxk	73	16	homologue	homologue	NN
cord-017764-h1w9gbxk	73	17	24	24	CD
cord-017764-h1w9gbxk	73	18	were	be	VBD
cord-017764-h1w9gbxk	73	19	discovered	discover	VBN
cord-017764-h1w9gbxk	73	20	to	to	TO
cord-017764-h1w9gbxk	73	21	exhibit	exhibit	VB
cord-017764-h1w9gbxk	73	22	weak	weak	JJ
cord-017764-h1w9gbxk	73	23	inhibition	inhibition	NN
cord-017764-h1w9gbxk	73	24	of	of	IN
cord-017764-h1w9gbxk	73	25	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	73	26	and	and	CC
cord-017764-h1w9gbxk	73	27	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	73	28	replicons	replicon	NNS
cord-017764-h1w9gbxk	73	29	,	,	,
cord-017764-h1w9gbxk	73	30	with	with	IN
cord-017764-h1w9gbxk	73	31	modeling	model	VBG
cord-017764-h1w9gbxk	73	32	studies	study	NNS
cord-017764-h1w9gbxk	73	33	suggesting	suggest	VBG
cord-017764-h1w9gbxk	73	34	that	that	IN
cord-017764-h1w9gbxk	73	35	the	the	DT
cord-017764-h1w9gbxk	73	36	effect	effect	NN
cord-017764-h1w9gbxk	73	37	of	of	IN
cord-017764-h1w9gbxk	73	38	substitution	substitution	NN
cord-017764-h1w9gbxk	73	39	was	be	VBD
cord-017764-h1w9gbxk	73	40	not	not	RB
cord-017764-h1w9gbxk	73	41	a	a	DT
cord-017764-h1w9gbxk	73	42	function	function	NN
cord-017764-h1w9gbxk	73	43	of	of	IN
cord-017764-h1w9gbxk	73	44	modulating	modulate	VBG
cord-017764-h1w9gbxk	73	45	the	the	DT
cord-017764-h1w9gbxk	73	46	conformation	conformation	NN
cord-017764-h1w9gbxk	73	47	between	between	IN
cord-017764-h1w9gbxk	73	48	the	the	DT
cord-017764-h1w9gbxk	73	49	phenyl	phenyl	NN
cord-017764-h1w9gbxk	73	50	ring	ring	NN
cord-017764-h1w9gbxk	73	51	and	and	CC
cord-017764-h1w9gbxk	73	52	proline	proline	NN
cord-017764-h1w9gbxk	73	53	carbonyl	carbonyl	NN
cord-017764-h1w9gbxk	73	54	[	[	-LRB-
cord-017764-h1w9gbxk	73	55	34	34	CD
cord-017764-h1w9gbxk	73	56	]	]	-RRB-
cord-017764-h1w9gbxk	73	57	.	.	.
cord-017764-h1w9gbxk	74	1	The	the	DT
cord-017764-h1w9gbxk	74	2	pyridine	pyridine	NN
cord-017764-h1w9gbxk	74	3	derivative	derivative	JJ
cord-017764-h1w9gbxk	74	4	25	25	CD
cord-017764-h1w9gbxk	74	5	further	further	RB
cord-017764-h1w9gbxk	74	6	advanced	advance	VBN
cord-017764-h1w9gbxk	74	7	the	the	DT
cord-017764-h1w9gbxk	74	8	SAR	SAR	NNP
cord-017764-h1w9gbxk	74	9	associated	associate	VBN
cord-017764-h1w9gbxk	74	10	with	with	IN
cord-017764-h1w9gbxk	74	11	this	this	DT
cord-017764-h1w9gbxk	74	12	cap	cap	NN
cord-017764-h1w9gbxk	74	13	element	element	NN
cord-017764-h1w9gbxk	74	14	but	but	CC
cord-017764-h1w9gbxk	74	15	,	,	,
cord-017764-h1w9gbxk	74	16	more	more	RBR
cord-017764-h1w9gbxk	74	17	importantly	importantly	RB
cord-017764-h1w9gbxk	74	18	,	,	,
cord-017764-h1w9gbxk	74	19	formed	form	VBD
cord-017764-h1w9gbxk	74	20	the	the	DT
cord-017764-h1w9gbxk	74	21	basis	basis	NN
cord-017764-h1w9gbxk	74	22	of	of	IN
cord-017764-h1w9gbxk	74	23	the	the	DT
cord-017764-h1w9gbxk	74	24	discovery	discovery	NN
cord-017764-h1w9gbxk	74	25	of	of	IN
cord-017764-h1w9gbxk	74	26	the	the	DT
cord-017764-h1w9gbxk	74	27	isoquinoline	isoquinoline	NN
cord-017764-h1w9gbxk	74	28	derivative	derivative	NNP
cord-017764-h1w9gbxk	74	29	26	26	CD
cord-017764-h1w9gbxk	74	30	,	,	,
cord-017764-h1w9gbxk	74	31	in	in	IN
cord-017764-h1w9gbxk	74	32	which	which	WDT
cord-017764-h1w9gbxk	74	33	the	the	DT
cord-017764-h1w9gbxk	74	34	ethyl	ethyl	NN
cord-017764-h1w9gbxk	74	35	substituent	substituent	NN
cord-017764-h1w9gbxk	74	36	was	be	VBD
cord-017764-h1w9gbxk	74	37	incorporated	incorporate	VBN
cord-017764-h1w9gbxk	74	38	into	into	IN
cord-017764-h1w9gbxk	74	39	a	a	DT
cord-017764-h1w9gbxk	74	40	fused	fused	JJ
cord-017764-h1w9gbxk	74	41	ring	ring	NN
cord-017764-h1w9gbxk	74	42	,	,	,
cord-017764-h1w9gbxk	74	43	as	as	IN
cord-017764-h1w9gbxk	74	44	the	the	DT
cord-017764-h1w9gbxk	74	45	first	first	JJ
cord-017764-h1w9gbxk	74	46	compound	compound	NN
cord-017764-h1w9gbxk	74	47	to	to	TO
cord-017764-h1w9gbxk	74	48	exhibit	exhibit	VB
cord-017764-h1w9gbxk	74	49	potent	potent	JJ
cord-017764-h1w9gbxk	74	50	and	and	CC
cord-017764-h1w9gbxk	74	51	balanced	balanced	JJ
cord-017764-h1w9gbxk	74	52	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	74	53	activity	activity	NN
cord-017764-h1w9gbxk	74	54	toward	toward	IN
cord-017764-h1w9gbxk	74	55	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	74	56	and	and	CC
cord-017764-h1w9gbxk	74	57	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	74	58	replicons	replicon	NNS
cord-017764-h1w9gbxk	74	59	[	[	-LRB-
cord-017764-h1w9gbxk	74	60	34	34	CD
cord-017764-h1w9gbxk	74	61	]	]	-RRB-
cord-017764-h1w9gbxk	74	62	.	.	.
cord-017764-h1w9gbxk	75	1	The	the	DT
cord-017764-h1w9gbxk	75	2	promise	promise	NN
cord-017764-h1w9gbxk	75	3	of	of	IN
cord-017764-h1w9gbxk	75	4	this	this	DT
cord-017764-h1w9gbxk	75	5	compound	compound	NN
cord-017764-h1w9gbxk	75	6	was	be	VBD
cord-017764-h1w9gbxk	75	7	further	further	RB
cord-017764-h1w9gbxk	75	8	underscored	underscore	VBN
cord-017764-h1w9gbxk	75	9	when	when	WRB
cord-017764-h1w9gbxk	75	10	it	-PRON-	PRP
cord-017764-h1w9gbxk	75	11	was	be	VBD
cord-017764-h1w9gbxk	75	12	screened	screen	VBN
cord-017764-h1w9gbxk	75	13	in	in	IN
cord-017764-h1w9gbxk	75	14	replicons	replicon	NNS
cord-017764-h1w9gbxk	75	15	or	or	CC
cord-017764-h1w9gbxk	75	16	hybrid	hybrid	JJ
cord-017764-h1w9gbxk	75	17	replicons	replicon	NNS
cord-017764-h1w9gbxk	75	18	representing	represent	VBG
cord-017764-h1w9gbxk	75	19	genotypes	genotype	NNS
cord-017764-h1w9gbxk	75	20	2a	2a	CD
cord-017764-h1w9gbxk	75	21	,	,	,
cord-017764-h1w9gbxk	75	22	3a	3a	NNP
cord-017764-h1w9gbxk	75	23	,	,	,
cord-017764-h1w9gbxk	75	24	and	and	CC
cord-017764-h1w9gbxk	75	25	5a	5a	CD
cord-017764-h1w9gbxk	75	26	where	where	WRB
cord-017764-h1w9gbxk	75	27	the	the	DT
cord-017764-h1w9gbxk	75	28	EC	EC	NNP
cord-017764-h1w9gbxk	75	29	50	50	CD
cord-017764-h1w9gbxk	75	30	values	value	NNS
cord-017764-h1w9gbxk	75	31	ranged	range	VBD
cord-017764-h1w9gbxk	75	32	from	from	IN
cord-017764-h1w9gbxk	75	33	2.2	2.2	CD
cord-017764-h1w9gbxk	75	34	to	to	IN
cord-017764-h1w9gbxk	75	35	14	14	CD
cord-017764-h1w9gbxk	76	1	nM.	nM.	NNP
cord-017764-h1w9gbxk	76	2	Further	further	JJ
cord-017764-h1w9gbxk	76	3	examination	examination	NN
cord-017764-h1w9gbxk	76	4	of	of	IN
cord-017764-h1w9gbxk	76	5	the	the	DT
cord-017764-h1w9gbxk	76	6	SARs	SARs	NNP
cord-017764-h1w9gbxk	76	7	revealed	reveal	VBD
cord-017764-h1w9gbxk	76	8	that	that	IN
cord-017764-h1w9gbxk	76	9	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	76	10	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	76	11	activity	activity	NN
cord-017764-h1w9gbxk	76	12	was	be	VBD
cord-017764-h1w9gbxk	76	13	much	much	RB
cord-017764-h1w9gbxk	76	14	more	more	RBR
cord-017764-h1w9gbxk	76	15	sensitive	sensitive	JJ
cord-017764-h1w9gbxk	76	16	to	to	IN
cord-017764-h1w9gbxk	76	17	the	the	DT
cord-017764-h1w9gbxk	76	18	nature	nature	NN
cord-017764-h1w9gbxk	76	19	and	and	CC
cord-017764-h1w9gbxk	76	20	the	the	DT
cord-017764-h1w9gbxk	76	21	substitution	substitution	NN
cord-017764-h1w9gbxk	76	22	pattern	pattern	NN
cord-017764-h1w9gbxk	76	23	of	of	IN
cord-017764-h1w9gbxk	76	24	the	the	DT
cord-017764-h1w9gbxk	76	25	isoquinoline	isoquinoline	NN
cord-017764-h1w9gbxk	76	26	ring	ring	NN
cord-017764-h1w9gbxk	76	27	than	than	IN
cord-017764-h1w9gbxk	76	28	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	76	29	[	[	-LRB-
cord-017764-h1w9gbxk	76	30	34	34	CD
cord-017764-h1w9gbxk	76	31	]	]	-RRB-
cord-017764-h1w9gbxk	76	32	.	.	.
cord-017764-h1w9gbxk	77	1	For	for	IN
cord-017764-h1w9gbxk	77	2	example	example	NN
cord-017764-h1w9gbxk	77	3	,	,	,
cord-017764-h1w9gbxk	77	4	27	27	CD
cord-017764-h1w9gbxk	77	5	,	,	,
cord-017764-h1w9gbxk	77	6	the	the	DT
cord-017764-h1w9gbxk	77	7	parental	parental	JJ
cord-017764-h1w9gbxk	77	8	analogue	analogue	NN
cord-017764-h1w9gbxk	77	9	of	of	IN
cord-017764-h1w9gbxk	77	10	26	26	CD
cord-017764-h1w9gbxk	77	11	,	,	,
cord-017764-h1w9gbxk	77	12	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	77	13	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	77	14	and	and	CC
cord-017764-h1w9gbxk	77	15	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	77	16	EC	EC	NNP
cord-017764-h1w9gbxk	77	17	50	50	CD
cord-017764-h1w9gbxk	77	18	values	value	NNS
cord-017764-h1w9gbxk	77	19	that	that	WDT
cord-017764-h1w9gbxk	77	20	were	be	VBD
cord-017764-h1w9gbxk	77	21	20-and	20-and	CD
cord-017764-h1w9gbxk	77	22	3-fold	3-fold	CD
cord-017764-h1w9gbxk	77	23	weaker	weak	JJR
cord-017764-h1w9gbxk	77	24	than	than	IN
cord-017764-h1w9gbxk	77	25	that	that	DT
cord-017764-h1w9gbxk	77	26	of	of	IN
cord-017764-h1w9gbxk	77	27	26	26	CD
cord-017764-h1w9gbxk	77	28	,	,	,
cord-017764-h1w9gbxk	77	29	respectively	respectively	RB
cord-017764-h1w9gbxk	77	30	.	.	.
cord-017764-h1w9gbxk	78	1	In	in	IN
cord-017764-h1w9gbxk	78	2	addition	addition	NN
cord-017764-h1w9gbxk	78	3	,	,	,
cord-017764-h1w9gbxk	78	4	the	the	DT
cord-017764-h1w9gbxk	78	5	methoxy	methoxy	RB
cord-017764-h1w9gbxk	78	6	-	-	HYPH
cord-017764-h1w9gbxk	78	7	substituted	substitute	VBN
cord-017764-h1w9gbxk	78	8	derivative	derivative	JJ
cord-017764-h1w9gbxk	78	9	28	28	CD
cord-017764-h1w9gbxk	78	10	and	and	CC
cord-017764-h1w9gbxk	78	11	its	-PRON-	PRP$
cord-017764-h1w9gbxk	78	12	chloro	chloro	NNS
cord-017764-h1w9gbxk	78	13	-	-	HYPH
cord-017764-h1w9gbxk	78	14	substituted	substitute	VBN
cord-017764-h1w9gbxk	78	15	analogue	analogue	NN
cord-017764-h1w9gbxk	78	16	29	29	CD
cord-017764-h1w9gbxk	78	17	retained	retain	VBD
cord-017764-h1w9gbxk	78	18	potent	potent	JJ
cord-017764-h1w9gbxk	78	19	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	78	20	inhibition	inhibition	NN
cord-017764-h1w9gbxk	78	21	,	,	,
cord-017764-h1w9gbxk	78	22	but	but	CC
cord-017764-h1w9gbxk	78	23	their	-PRON-	PRP$
cord-017764-h1w9gbxk	78	24	GT-1a	gt-1a	NN
cord-017764-h1w9gbxk	78	25	EC	EC	NNP
cord-017764-h1w9gbxk	78	26	50	50	CD
cord-017764-h1w9gbxk	78	27	values	value	NNS
cord-017764-h1w9gbxk	78	28	were	be	VBD
cord-017764-h1w9gbxk	78	29	>	>	XX
cord-017764-h1w9gbxk	78	30	10	10	CD
cord-017764-h1w9gbxk	79	1	μM.	μM.	NNP
cord-017764-h1w9gbxk	80	1	However	however	RB
cord-017764-h1w9gbxk	80	2	,	,	,
cord-017764-h1w9gbxk	80	3	a	a	DT
cord-017764-h1w9gbxk	80	4	more	more	RBR
cord-017764-h1w9gbxk	80	5	fruitful	fruitful	JJ
cord-017764-h1w9gbxk	80	6	avenue	avenue	NN
cord-017764-h1w9gbxk	80	7	of	of	IN
cord-017764-h1w9gbxk	80	8	investigation	investigation	NN
cord-017764-h1w9gbxk	80	9	was	be	VBD
cord-017764-h1w9gbxk	80	10	found	find	VBN
cord-017764-h1w9gbxk	80	11	when	when	WRB
cord-017764-h1w9gbxk	80	12	the	the	DT
cord-017764-h1w9gbxk	80	13	effects	effect	NNS
cord-017764-h1w9gbxk	80	14	of	of	IN
cord-017764-h1w9gbxk	80	15	deannulating	deannulate	VBG
cord-017764-h1w9gbxk	80	16	the	the	DT
cord-017764-h1w9gbxk	80	17	isoquinoline	isoquinoline	NN
cord-017764-h1w9gbxk	80	18	ring	ring	NN
cord-017764-h1w9gbxk	80	19	were	be	VBD
cord-017764-h1w9gbxk	80	20	probed	probe	VBN
cord-017764-h1w9gbxk	80	21	[	[	-LRB-
cord-017764-h1w9gbxk	80	22	35	35	CD
cord-017764-h1w9gbxk	80	23	]	]	-RRB-
cord-017764-h1w9gbxk	80	24	.	.	.
cord-017764-h1w9gbxk	81	1	The	the	DT
cord-017764-h1w9gbxk	81	2	α	α	NN
cord-017764-h1w9gbxk	81	3	-	-	HYPH
cord-017764-h1w9gbxk	81	4	keto	keto	NNP
cord-017764-h1w9gbxk	81	5	amide	amide	NN
cord-017764-h1w9gbxk	81	6	30	30	CD
cord-017764-h1w9gbxk	81	7	preserved	preserve	VBD
cord-017764-h1w9gbxk	81	8	the	the	DT
cord-017764-h1w9gbxk	81	9	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	81	10	inhibition	inhibition	NN
cord-017764-h1w9gbxk	81	11	exhibited	exhibit	VBN
cord-017764-h1w9gbxk	81	12	by	by	IN
cord-017764-h1w9gbxk	81	13	26	26	CD
cord-017764-h1w9gbxk	81	14	,	,	,
cord-017764-h1w9gbxk	81	15	while	while	IN
cord-017764-h1w9gbxk	81	16	the	the	DT
cord-017764-h1w9gbxk	81	17	derived	derive	VBN
cord-017764-h1w9gbxk	81	18	secondary	secondary	JJ
cord-017764-h1w9gbxk	81	19	alcohols	alcohol	NNS
cord-017764-h1w9gbxk	81	20	31	31	CD
cord-017764-h1w9gbxk	81	21	and	and	CC
cord-017764-h1w9gbxk	81	22	32	32	CD
cord-017764-h1w9gbxk	81	23	demonstrated	demonstrate	VBD
cord-017764-h1w9gbxk	81	24	that	that	IN
cord-017764-h1w9gbxk	81	25	planarity	planarity	NN
cord-017764-h1w9gbxk	81	26	at	at	IN
cord-017764-h1w9gbxk	81	27	this	this	DT
cord-017764-h1w9gbxk	81	28	site	site	NN
cord-017764-h1w9gbxk	81	29	was	be	VBD
cord-017764-h1w9gbxk	81	30	not	not	RB
cord-017764-h1w9gbxk	81	31	a	a	DT
cord-017764-h1w9gbxk	81	32	specific	specific	JJ
cord-017764-h1w9gbxk	81	33	requirement	requirement	NN
cord-017764-h1w9gbxk	81	34	.	.	.
cord-017764-h1w9gbxk	82	1	The	the	DT
cord-017764-h1w9gbxk	82	2	tertiary	tertiary	JJ
cord-017764-h1w9gbxk	82	3	alcohol	alcohol	NN
cord-017764-h1w9gbxk	82	4	homologues	homologue	NNS
cord-017764-h1w9gbxk	82	5	33	33	CD
cord-017764-h1w9gbxk	82	6	and	and	CC
cord-017764-h1w9gbxk	82	7	34	34	CD
cord-017764-h1w9gbxk	82	8	added	add	VBD
cord-017764-h1w9gbxk	82	9	further	further	RB
cord-017764-h1w9gbxk	82	10	to	to	IN
cord-017764-h1w9gbxk	82	11	the	the	DT
cord-017764-h1w9gbxk	82	12	SARs	sar	NNS
cord-017764-h1w9gbxk	82	13	,	,	,
cord-017764-h1w9gbxk	82	14	with	with	IN
cord-017764-h1w9gbxk	82	15	the	the	DT
cord-017764-h1w9gbxk	82	16	(	(	-LRB-
cord-017764-h1w9gbxk	82	17	S	S	NNP
cord-017764-h1w9gbxk	82	18	,	,	,
cord-017764-h1w9gbxk	82	19	S)-analogue	S)-analogue	NNP
cord-017764-h1w9gbxk	82	20	34	34	CD
cord-017764-h1w9gbxk	82	21	the	the	DT
cord-017764-h1w9gbxk	82	22	more	more	RBR
cord-017764-h1w9gbxk	82	23	potent	potent	JJ
cord-017764-h1w9gbxk	82	24	isomer	isomer	NN
cord-017764-h1w9gbxk	82	25	,	,	,
cord-017764-h1w9gbxk	82	26	particularly	particularly	RB
cord-017764-h1w9gbxk	82	27	toward	toward	IN
cord-017764-h1w9gbxk	82	28	the	the	DT
cord-017764-h1w9gbxk	82	29	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	82	30	replicon	replicon	NN
cord-017764-h1w9gbxk	82	31	where	where	WRB
cord-017764-h1w9gbxk	82	32	the	the	DT
cord-017764-h1w9gbxk	82	33	EC	EC	NNP
cord-017764-h1w9gbxk	82	34	50	50	CD
cord-017764-h1w9gbxk	82	35	value	value	NN
cord-017764-h1w9gbxk	82	36	was	be	VBD
cord-017764-h1w9gbxk	82	37	6	6	CD
cord-017764-h1w9gbxk	82	38	pM.	pm.	NN
cord-017764-h1w9gbxk	83	1	Another	another	DT
cord-017764-h1w9gbxk	83	2	encouraging	encouraging	JJ
cord-017764-h1w9gbxk	83	3	observation	observation	NN
cord-017764-h1w9gbxk	83	4	was	be	VBD
cord-017764-h1w9gbxk	83	5	made	make	VBN
cord-017764-h1w9gbxk	83	6	with	with	IN
cord-017764-h1w9gbxk	83	7	35	35	CD
cord-017764-h1w9gbxk	83	8	which	which	WDT
cord-017764-h1w9gbxk	83	9	,	,	,
cord-017764-h1w9gbxk	83	10	although	although	IN
cord-017764-h1w9gbxk	83	11	poorly	poorly	RB
cord-017764-h1w9gbxk	83	12	active	active	JJ
cord-017764-h1w9gbxk	83	13	in	in	IN
cord-017764-h1w9gbxk	83	14	the	the	DT
cord-017764-h1w9gbxk	83	15	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	83	16	replicon	replicon	NN
cord-017764-h1w9gbxk	83	17	,	,	,
cord-017764-h1w9gbxk	83	18	demonstrated	demonstrate	VBD
cord-017764-h1w9gbxk	83	19	64	64	CD
cord-017764-h1w9gbxk	83	20	%	%	NN
cord-017764-h1w9gbxk	83	21	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	83	22	following	follow	VBG
cord-017764-h1w9gbxk	83	23	oral	oral	JJ
cord-017764-h1w9gbxk	83	24	dosing	dosing	NN
cord-017764-h1w9gbxk	83	25	to	to	IN
cord-017764-h1w9gbxk	83	26	rats	rat	NNS
cord-017764-h1w9gbxk	83	27	,	,	,
cord-017764-h1w9gbxk	83	28	indicating	indicate	VBG
cord-017764-h1w9gbxk	83	29	that	that	IN
cord-017764-h1w9gbxk	83	30	securing	secure	VBG
cord-017764-h1w9gbxk	83	31	systemic	systemic	JJ
cord-017764-h1w9gbxk	83	32	exposure	exposure	NN
cord-017764-h1w9gbxk	83	33	after	after	IN
cord-017764-h1w9gbxk	83	34	oral	oral	JJ
cord-017764-h1w9gbxk	83	35	delivery	delivery	NN
cord-017764-h1w9gbxk	83	36	of	of	IN
cord-017764-h1w9gbxk	83	37	these	these	DT
cord-017764-h1w9gbxk	83	38	symmetrical	symmetrical	JJ
cord-017764-h1w9gbxk	83	39	stilbene	stilbene	JJ
cord-017764-h1w9gbxk	83	40	derivatives	derivative	NNS
cord-017764-h1w9gbxk	83	41	was	be	VBD
cord-017764-h1w9gbxk	83	42	feasible	feasible	JJ
cord-017764-h1w9gbxk	83	43	.	.	.
cord-017764-h1w9gbxk	84	1	Replacing	replace	VBG
cord-017764-h1w9gbxk	84	2	the	the	DT
cord-017764-h1w9gbxk	84	3	stilbene	stilbene	JJ
cord-017764-h1w9gbxk	84	4	element	element	NN
cord-017764-h1w9gbxk	84	5	with	with	IN
cord-017764-h1w9gbxk	84	6	an	an	DT
cord-017764-h1w9gbxk	84	7	alkyne	alkyne	NN
cord-017764-h1w9gbxk	84	8	,	,	,
cord-017764-h1w9gbxk	84	9	which	which	WDT
cord-017764-h1w9gbxk	84	10	resolved	resolve	VBD
cord-017764-h1w9gbxk	84	11	a	a	DT
cord-017764-h1w9gbxk	84	12	cis	cis	JJ
cord-017764-h1w9gbxk	84	13	-	-	HYPH
cord-017764-h1w9gbxk	84	14	trans	trans	NNP
cord-017764-h1w9gbxk	84	15	isomerization	isomerization	NN
cord-017764-h1w9gbxk	84	16	issue	issue	NN
cord-017764-h1w9gbxk	84	17	observed	observe	VBD
cord-017764-h1w9gbxk	84	18	with	with	IN
cord-017764-h1w9gbxk	84	19	some	some	DT
cord-017764-h1w9gbxk	84	20	analogues	analogue	NNS
cord-017764-h1w9gbxk	84	21	,	,	,
cord-017764-h1w9gbxk	84	22	added	add	VBN
cord-017764-h1w9gbxk	84	23	further	further	RB
cord-017764-h1w9gbxk	84	24	to	to	IN
cord-017764-h1w9gbxk	84	25	the	the	DT
cord-017764-h1w9gbxk	84	26	understanding	understanding	NN
cord-017764-h1w9gbxk	84	27	of	of	IN
cord-017764-h1w9gbxk	84	28	the	the	DT
cord-017764-h1w9gbxk	84	29	topography	topography	NN
cord-017764-h1w9gbxk	84	30	of	of	IN
cord-017764-h1w9gbxk	84	31	the	the	DT
cord-017764-h1w9gbxk	84	32	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	84	33	.	.	.
cord-017764-h1w9gbxk	85	1	Additional	additional	JJ
cord-017764-h1w9gbxk	85	2	probing	probing	NN
cord-017764-h1w9gbxk	85	3	of	of	IN
cord-017764-h1w9gbxk	85	4	the	the	DT
cord-017764-h1w9gbxk	85	5	amino	amino	NN
cord-017764-h1w9gbxk	85	6	acid	acid	NN
cord-017764-h1w9gbxk	85	7	terminal	terminal	NN
cord-017764-h1w9gbxk	85	8	region	region	NN
cord-017764-h1w9gbxk	85	9	using	use	VBG
cord-017764-h1w9gbxk	85	10	this	this	DT
cord-017764-h1w9gbxk	85	11	alkyne	alkyne	NN
cord-017764-h1w9gbxk	85	12	-	-	HYPH
cord-017764-h1w9gbxk	85	13	based	base	VBN
cord-017764-h1w9gbxk	85	14	scaffold	scaffold	NN
cord-017764-h1w9gbxk	85	15	identified	identify	VBD
cord-017764-h1w9gbxk	85	16	potent	potent	JJ
cord-017764-h1w9gbxk	85	17	arylglycine	arylglycine	NN
cord-017764-h1w9gbxk	85	18	-	-	HYPH
cord-017764-h1w9gbxk	85	19	based	base	VBN
cord-017764-h1w9gbxk	85	20	analogues	analogue	NNS
cord-017764-h1w9gbxk	85	21	for	for	IN
cord-017764-h1w9gbxk	85	22	which	which	WDT
cord-017764-h1w9gbxk	85	23	the	the	DT
cord-017764-h1w9gbxk	85	24	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	85	25	EC	EC	NNP
cord-017764-h1w9gbxk	85	26	50	50	CD
cord-017764-h1w9gbxk	85	27	values	value	NNS
cord-017764-h1w9gbxk	85	28	for	for	IN
cord-017764-h1w9gbxk	85	29	some	some	DT
cord-017764-h1w9gbxk	85	30	compounds	compound	NNS
cord-017764-h1w9gbxk	85	31	,	,	,
cord-017764-h1w9gbxk	85	32	including	include	VBG
cord-017764-h1w9gbxk	85	33	36	36	CD
cord-017764-h1w9gbxk	85	34	-	-	SYM
cord-017764-h1w9gbxk	85	35	38	38	CD
cord-017764-h1w9gbxk	85	36	,	,	,
cord-017764-h1w9gbxk	85	37	were	be	VBD
cord-017764-h1w9gbxk	85	38	single	single	JJ
cord-017764-h1w9gbxk	85	39	digit	digit	NN
cord-017764-h1w9gbxk	85	40	nM	nm	NN
cord-017764-h1w9gbxk	85	41	[	[	-LRB-
cord-017764-h1w9gbxk	85	42	35	35	CD
cord-017764-h1w9gbxk	85	43	]	]	-RRB-
cord-017764-h1w9gbxk	85	44	.	.	.
cord-017764-h1w9gbxk	86	1	Notably	notably	RB
cord-017764-h1w9gbxk	86	2	,	,	,
cord-017764-h1w9gbxk	86	3	the	the	DT
cord-017764-h1w9gbxk	86	4	change	change	NN
cord-017764-h1w9gbxk	86	5	in	in	IN
cord-017764-h1w9gbxk	86	6	stereochemical	stereochemical	JJ
cord-017764-h1w9gbxk	86	7	preference	preference	NN
cord-017764-h1w9gbxk	86	8	in	in	IN
cord-017764-h1w9gbxk	86	9	evolving	evolve	VBG
cord-017764-h1w9gbxk	86	10	the	the	DT
cord-017764-h1w9gbxk	86	11	chemotype	chemotype	NN
cord-017764-h1w9gbxk	86	12	from	from	IN
cord-017764-h1w9gbxk	86	13	the	the	DT
cord-017764-h1w9gbxk	86	14	mandelamide	mandelamide	NNP
cord-017764-h1w9gbxk	86	15	analogues	analogues	NNP
cord-017764-h1w9gbxk	86	16	33	33	CD
cord-017764-h1w9gbxk	86	17	and	and	CC
cord-017764-h1w9gbxk	86	18	34	34	CD
cord-017764-h1w9gbxk	86	19	to	to	IN
cord-017764-h1w9gbxk	86	20	the	the	DT
cord-017764-h1w9gbxk	86	21	phenylglycine	phenylglycine	NNP
cord-017764-h1w9gbxk	86	22	analogues	analogues	NNP
cord-017764-h1w9gbxk	86	23	36	36	CD
cord-017764-h1w9gbxk	86	24	and	and	CC
cord-017764-h1w9gbxk	86	25	37	37	CD
cord-017764-h1w9gbxk	86	26	further	further	RB
cord-017764-h1w9gbxk	86	27	highlighted	highlight	VBD
cord-017764-h1w9gbxk	86	28	the	the	DT
cord-017764-h1w9gbxk	86	29	relatively	relatively	JJ
cord-017764-h1w9gbxk	86	30	intricacy	intricacy	NN
cord-017764-h1w9gbxk	86	31	and	and	CC
cord-017764-h1w9gbxk	86	32	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	86	33	of	of	IN
cord-017764-h1w9gbxk	86	34	the	the	DT
cord-017764-h1w9gbxk	86	35	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	86	36	inhibition	inhibition	NN
cord-017764-h1w9gbxk	86	37	SARs	sar	NNS
cord-017764-h1w9gbxk	86	38	that	that	WDT
cord-017764-h1w9gbxk	86	39	were	be	VBD
cord-017764-h1w9gbxk	86	40	being	be	VBG
cord-017764-h1w9gbxk	86	41	uncovered	uncover	VBN
cord-017764-h1w9gbxk	86	42	during	during	IN
cord-017764-h1w9gbxk	86	43	this	this	DT
cord-017764-h1w9gbxk	86	44	phase	phase	NN
cord-017764-h1w9gbxk	86	45	of	of	IN
cord-017764-h1w9gbxk	86	46	the	the	DT
cord-017764-h1w9gbxk	86	47	project	project	NN
cord-017764-h1w9gbxk	86	48	.	.	.
cord-017764-h1w9gbxk	87	1	Equally	equally	RB
cord-017764-h1w9gbxk	87	2	intriguing	intriguing	JJ
cord-017764-h1w9gbxk	87	3	was	be	VBD
cord-017764-h1w9gbxk	87	4	the	the	DT
cord-017764-h1w9gbxk	87	5	accumulating	accumulate	VBG
cord-017764-h1w9gbxk	87	6	evidence	evidence	NN
cord-017764-h1w9gbxk	87	7	indicating	indicate	VBG
cord-017764-h1w9gbxk	87	8	that	that	IN
cord-017764-h1w9gbxk	87	9	the	the	DT
cord-017764-h1w9gbxk	87	10	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	87	11	virus	virus	NN
cord-017764-h1w9gbxk	87	12	was	be	VBD
cord-017764-h1w9gbxk	87	13	highly	highly	RB
cord-017764-h1w9gbxk	87	14	tolerant	tolerant	JJ
cord-017764-h1w9gbxk	87	15	of	of	IN
cord-017764-h1w9gbxk	87	16	many	many	JJ
cord-017764-h1w9gbxk	87	17	structural	structural	JJ
cord-017764-h1w9gbxk	87	18	changes	change	NNS
cord-017764-h1w9gbxk	87	19	,	,	,
cord-017764-h1w9gbxk	87	20	an	an	DT
cord-017764-h1w9gbxk	87	21	observation	observation	NN
cord-017764-h1w9gbxk	87	22	that	that	WDT
cord-017764-h1w9gbxk	87	23	could	could	MD
cord-017764-h1w9gbxk	87	24	not	not	RB
cord-017764-h1w9gbxk	87	25	readily	readily	RB
cord-017764-h1w9gbxk	87	26	be	be	VB
cord-017764-h1w9gbxk	87	27	explained	explain	VBN
cord-017764-h1w9gbxk	87	28	based	base	VBN
cord-017764-h1w9gbxk	87	29	on	on	IN
cord-017764-h1w9gbxk	87	30	the	the	DT
cord-017764-h1w9gbxk	87	31	differences	difference	NNS
cord-017764-h1w9gbxk	87	32	in	in	IN
cord-017764-h1w9gbxk	87	33	amino	amino	NN
cord-017764-h1w9gbxk	87	34	acid	acid	NN
cord-017764-h1w9gbxk	87	35	composition	composition	NN
cord-017764-h1w9gbxk	87	36	at	at	IN
cord-017764-h1w9gbxk	87	37	the	the	DT
cord-017764-h1w9gbxk	87	38	putative	putative	JJ
cord-017764-h1w9gbxk	87	39	binding	binding	NN
cord-017764-h1w9gbxk	87	40	site	site	NN
cord-017764-h1w9gbxk	87	41	of	of	IN
cord-017764-h1w9gbxk	87	42	the	the	DT
cord-017764-h1w9gbxk	87	43	compounds	compound	NNS
cord-017764-h1w9gbxk	87	44	.	.	.
cord-017764-h1w9gbxk	88	1	A	a	DT
cord-017764-h1w9gbxk	88	2	concurrent	concurrent	JJ
cord-017764-h1w9gbxk	88	3	effort	effort	NN
cord-017764-h1w9gbxk	88	4	examined	examine	VBD
cord-017764-h1w9gbxk	88	5	scaffold	scaffold	NN
cord-017764-h1w9gbxk	88	6	modifications	modification	NNS
cord-017764-h1w9gbxk	88	7	directed	direct	VBN
cord-017764-h1w9gbxk	88	8	toward	toward	IN
cord-017764-h1w9gbxk	88	9	the	the	DT
cord-017764-h1w9gbxk	88	10	identification	identification	NN
cord-017764-h1w9gbxk	88	11	of	of	IN
cord-017764-h1w9gbxk	88	12	a	a	DT
cord-017764-h1w9gbxk	88	13	less	less	RBR
cord-017764-h1w9gbxk	88	14	problematic	problematic	JJ
cord-017764-h1w9gbxk	88	15	replacement	replacement	NN
cord-017764-h1w9gbxk	88	16	for	for	IN
cord-017764-h1w9gbxk	88	17	the	the	DT
cord-017764-h1w9gbxk	88	18	anilide	anilide	NNP
cord-017764-h1w9gbxk	88	19	moiety	moiety	NN
cord-017764-h1w9gbxk	88	20	that	that	WDT
cord-017764-h1w9gbxk	88	21	would	would	MD
cord-017764-h1w9gbxk	88	22	decrease	decrease	VB
cord-017764-h1w9gbxk	88	23	or	or	CC
cord-017764-h1w9gbxk	88	24	eliminate	eliminate	VB
cord-017764-h1w9gbxk	88	25	the	the	DT
cord-017764-h1w9gbxk	88	26	potential	potential	NN
cord-017764-h1w9gbxk	88	27	for	for	IN
cord-017764-h1w9gbxk	88	28	aniline	aniline	NN
cord-017764-h1w9gbxk	88	29	release	release	NN
cord-017764-h1w9gbxk	88	30	in	in	IN
cord-017764-h1w9gbxk	88	31	vivo	vivo	NN
cord-017764-h1w9gbxk	88	32	which	which	WDT
cord-017764-h1w9gbxk	88	33	led	lead	VBD
cord-017764-h1w9gbxk	88	34	to	to	IN
cord-017764-h1w9gbxk	88	35	the	the	DT
cord-017764-h1w9gbxk	88	36	emergence	emergence	NN
cord-017764-h1w9gbxk	88	37	of	of	IN
cord-017764-h1w9gbxk	88	38	two	two	CD
cord-017764-h1w9gbxk	88	39	noteworthy	noteworthy	JJ
cord-017764-h1w9gbxk	88	40	SAR	SAR	NNP
cord-017764-h1w9gbxk	88	41	findings	finding	NNS
cord-017764-h1w9gbxk	88	42	.	.	.
cord-017764-h1w9gbxk	89	1	Firstly	firstly	RB
cord-017764-h1w9gbxk	89	2	,	,	,
cord-017764-h1w9gbxk	89	3	the	the	DT
cord-017764-h1w9gbxk	89	4	replacement	replacement	NN
cord-017764-h1w9gbxk	89	5	of	of	IN
cord-017764-h1w9gbxk	89	6	the	the	DT
cord-017764-h1w9gbxk	89	7	anilide	anilide	NNP
cord-017764-h1w9gbxk	89	8	moieties	moiety	NNS
cord-017764-h1w9gbxk	89	9	of	of	IN
cord-017764-h1w9gbxk	89	10	36	36	CD
cord-017764-h1w9gbxk	89	11	and	and	CC
cord-017764-h1w9gbxk	89	12	38	38	CD
cord-017764-h1w9gbxk	89	13	with	with	IN
cord-017764-h1w9gbxk	89	14	a	a	DT
cord-017764-h1w9gbxk	89	15	benzimidazole	benzimidazole	NN
cord-017764-h1w9gbxk	89	16	,	,	,
cord-017764-h1w9gbxk	89	17	a	a	DT
cord-017764-h1w9gbxk	89	18	design	design	NN
cord-017764-h1w9gbxk	89	19	intended	intend	VBN
cord-017764-h1w9gbxk	89	20	to	to	TO
cord-017764-h1w9gbxk	89	21	preserve	preserve	VB
cord-017764-h1w9gbxk	89	22	both	both	CC
cord-017764-h1w9gbxk	89	23	the	the	DT
cord-017764-h1w9gbxk	89	24	H	h	NN
cord-017764-h1w9gbxk	89	25	-	-	HYPH
cord-017764-h1w9gbxk	89	26	bond	bond	NN
cord-017764-h1w9gbxk	89	27	donor	donor	NN
cord-017764-h1w9gbxk	89	28	and	and	CC
cord-017764-h1w9gbxk	89	29	acceptor	acceptor	NN
cord-017764-h1w9gbxk	89	30	properties	property	NNS
cord-017764-h1w9gbxk	89	31	of	of	IN
cord-017764-h1w9gbxk	89	32	the	the	DT
cord-017764-h1w9gbxk	89	33	anilide	anilide	NN
cord-017764-h1w9gbxk	89	34	,	,	,
cord-017764-h1w9gbxk	89	35	resulted	result	VBD
cord-017764-h1w9gbxk	89	36	in	in	IN
cord-017764-h1w9gbxk	89	37	a	a	DT
cord-017764-h1w9gbxk	89	38	4-to	4-to	CD
cord-017764-h1w9gbxk	89	39	30-fold	30-fold	IN
cord-017764-h1w9gbxk	89	40	reduction	reduction	NN
cord-017764-h1w9gbxk	89	41	in	in	IN
cord-017764-h1w9gbxk	89	42	potency	potency	NN
cord-017764-h1w9gbxk	89	43	toward	toward	IN
cord-017764-h1w9gbxk	89	44	the	the	DT
cord-017764-h1w9gbxk	89	45	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	89	46	replicon	replicon	NN
cord-017764-h1w9gbxk	89	47	,	,	,
cord-017764-h1w9gbxk	89	48	as	as	IN
cord-017764-h1w9gbxk	89	49	exemplified	exemplify	VBN
cord-017764-h1w9gbxk	89	50	by	by	IN
cord-017764-h1w9gbxk	89	51	39	39	CD
cord-017764-h1w9gbxk	89	52	and	and	CC
cord-017764-h1w9gbxk	89	53	40	40	CD
cord-017764-h1w9gbxk	89	54	[	[	-LRB-
cord-017764-h1w9gbxk	89	55	36	36	CD
cord-017764-h1w9gbxk	89	56	]	]	-RRB-
cord-017764-h1w9gbxk	89	57	.	.	.
cord-017764-h1w9gbxk	90	1	Secondly	secondly	RB
cord-017764-h1w9gbxk	90	2	,	,	,
cord-017764-h1w9gbxk	90	3	a	a	DT
cord-017764-h1w9gbxk	90	4	mix	mix	NN
cord-017764-h1w9gbxk	90	5	and	and	CC
cord-017764-h1w9gbxk	90	6	match	match	VB
cord-017764-h1w9gbxk	90	7	SAR	SAR	NNP
cord-017764-h1w9gbxk	90	8	exercise	exercise	NN
cord-017764-h1w9gbxk	90	9	accentuated	accentuate	VBD
cord-017764-h1w9gbxk	90	10	the	the	DT
cord-017764-h1w9gbxk	90	11	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	90	12	of	of	IN
cord-017764-h1w9gbxk	90	13	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	90	14	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	90	15	potency	potency	NN
cord-017764-h1w9gbxk	90	16	to	to	IN
cord-017764-h1w9gbxk	90	17	topological	topological	JJ
cord-017764-h1w9gbxk	90	18	parameters	parameter	NNS
cord-017764-h1w9gbxk	90	19	,	,	,
cord-017764-h1w9gbxk	90	20	exemplified	exemplify	VBN
cord-017764-h1w9gbxk	90	21	by	by	IN
cord-017764-h1w9gbxk	90	22	the	the	DT
cord-017764-h1w9gbxk	90	23	70-fold	70-fold	CD
cord-017764-h1w9gbxk	90	24	difference	difference	NN
cord-017764-h1w9gbxk	90	25	in	in	IN
cord-017764-h1w9gbxk	90	26	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	90	27	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	90	28	potency	potency	NN
cord-017764-h1w9gbxk	90	29	between	between	IN
cord-017764-h1w9gbxk	90	30	regioisomers	regioisomer	NNS
cord-017764-h1w9gbxk	90	31	41	41	CD
cord-017764-h1w9gbxk	90	32	and	and	CC
cord-017764-h1w9gbxk	90	33	42	42	CD
cord-017764-h1w9gbxk	90	34	.	.	.
cord-017764-h1w9gbxk	91	1	These	these	DT
cord-017764-h1w9gbxk	91	2	SAR	SAR	NNP
cord-017764-h1w9gbxk	91	3	findings	finding	NNS
cord-017764-h1w9gbxk	91	4	were	be	VBD
cord-017764-h1w9gbxk	91	5	attributed	attribute	VBN
cord-017764-h1w9gbxk	91	6	to	to	IN
cord-017764-h1w9gbxk	91	7	the	the	DT
cord-017764-h1w9gbxk	91	8	altered	altered	JJ
cord-017764-h1w9gbxk	91	9	topology	topology	NN
cord-017764-h1w9gbxk	91	10	of	of	IN
cord-017764-h1w9gbxk	91	11	the	the	DT
cord-017764-h1w9gbxk	91	12	peripheral	peripheral	JJ
cord-017764-h1w9gbxk	91	13	pharmacophoric	pharmacophoric	JJ
cord-017764-h1w9gbxk	91	14	elements	element	NNS
cord-017764-h1w9gbxk	91	15	with	with	IN
cord-017764-h1w9gbxk	91	16	respect	respect	NN
cord-017764-h1w9gbxk	91	17	to	to	IN
cord-017764-h1w9gbxk	91	18	the	the	DT
cord-017764-h1w9gbxk	91	19	core	core	NN
cord-017764-h1w9gbxk	91	20	,	,	,
cord-017764-h1w9gbxk	91	21	a	a	DT
cord-017764-h1w9gbxk	91	22	shortcoming	shortcoming	NN
cord-017764-h1w9gbxk	91	23	that	that	WDT
cord-017764-h1w9gbxk	91	24	was	be	VBD
cord-017764-h1w9gbxk	91	25	ultimately	ultimately	RB
cord-017764-h1w9gbxk	91	26	addressed	address	VBN
cord-017764-h1w9gbxk	91	27	by	by	IN
cord-017764-h1w9gbxk	91	28	the	the	DT
cord-017764-h1w9gbxk	91	29	biphenyl	biphenyl	NNP
cord-017764-h1w9gbxk	91	30	derivatives	derivative	NNS
cord-017764-h1w9gbxk	91	31	43	43	CD
cord-017764-h1w9gbxk	91	32	and	and	CC
cord-017764-h1w9gbxk	91	33	44	44	CD
cord-017764-h1w9gbxk	91	34	which	which	WDT
cord-017764-h1w9gbxk	91	35	recapitulate	recapitulate	VBP
cord-017764-h1w9gbxk	91	36	the	the	DT
cord-017764-h1w9gbxk	91	37	linearity	linearity	NN
cord-017764-h1w9gbxk	91	38	The	The	NNP
cord-017764-h1w9gbxk	91	39	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	91	40	and	and	CC
cord-017764-h1w9gbxk	91	41	Development	Development	NNP
cord-017764-h1w9gbxk	91	42	of	of	IN
cord-017764-h1w9gbxk	91	43	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	91	44	:	:	:
cord-017764-h1w9gbxk	92	1	An	an	DT
cord-017764-h1w9gbxk	92	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	92	3	of	of	IN
cord-017764-h1w9gbxk	92	4	the	the	DT
cord-017764-h1w9gbxk	92	5	.	.	.
cord-017764-h1w9gbxk	92	6	.	.	.
cord-017764-h1w9gbxk	92	7	.	.	.
cord-017764-h1w9gbxk	93	1	associated	associate	VBN
cord-017764-h1w9gbxk	93	2	with	with	IN
cord-017764-h1w9gbxk	93	3	the	the	DT
cord-017764-h1w9gbxk	93	4	core	core	NN
cord-017764-h1w9gbxk	93	5	alkynes	alkyne	NNS
cord-017764-h1w9gbxk	93	6	in	in	IN
cord-017764-h1w9gbxk	93	7	36	36	CD
cord-017764-h1w9gbxk	93	8	-	-	SYM
cord-017764-h1w9gbxk	93	9	40	40	CD
cord-017764-h1w9gbxk	93	10	.	.	.
cord-017764-h1w9gbxk	94	1	In	in	IN
cord-017764-h1w9gbxk	94	2	43	43	CD
cord-017764-h1w9gbxk	94	3	and	and	CC
cord-017764-h1w9gbxk	94	4	44	44	CD
cord-017764-h1w9gbxk	94	5	,	,	,
cord-017764-h1w9gbxk	94	6	a	a	DT
cord-017764-h1w9gbxk	94	7	motif	motif	NN
cord-017764-h1w9gbxk	94	8	that	that	WDT
cord-017764-h1w9gbxk	94	9	was	be	VBD
cord-017764-h1w9gbxk	94	10	arrived	arrive	VBN
cord-017764-h1w9gbxk	94	11	at	at	IN
cord-017764-h1w9gbxk	94	12	only	only	RB
cord-017764-h1w9gbxk	94	13	after	after	IN
cord-017764-h1w9gbxk	94	14	considerable	considerable	JJ
cord-017764-h1w9gbxk	94	15	experimentation	experimentation	NN
cord-017764-h1w9gbxk	94	16	,	,	,
cord-017764-h1w9gbxk	94	17	deannelation	deannelation	NN
cord-017764-h1w9gbxk	94	18	of	of	IN
cord-017764-h1w9gbxk	94	19	the	the	DT
cord-017764-h1w9gbxk	94	20	benzimidazole	benzimidazole	NN
cord-017764-h1w9gbxk	94	21	ring	ring	NN
cord-017764-h1w9gbxk	94	22	provided	provide	VBD
cord-017764-h1w9gbxk	94	23	a	a	DT
cord-017764-h1w9gbxk	94	24	structural	structural	JJ
cord-017764-h1w9gbxk	94	25	arrangement	arrangement	NN
cord-017764-h1w9gbxk	94	26	that	that	WDT
cord-017764-h1w9gbxk	94	27	compensated	compensate	VBD
cord-017764-h1w9gbxk	94	28	for	for	IN
cord-017764-h1w9gbxk	94	29	the	the	DT
cord-017764-h1w9gbxk	94	30	reduced	reduce	VBN
cord-017764-h1w9gbxk	94	31	length	length	NN
cord-017764-h1w9gbxk	94	32	of	of	IN
cord-017764-h1w9gbxk	94	33	the	the	DT
cord-017764-h1w9gbxk	94	34	core	core	NN
cord-017764-h1w9gbxk	94	35	of	of	IN
cord-017764-h1w9gbxk	94	36	the	the	DT
cord-017764-h1w9gbxk	94	37	pharmacophore	pharmacophore	NN
cord-017764-h1w9gbxk	94	38	relative	relative	JJ
cord-017764-h1w9gbxk	94	39	to	to	IN
cord-017764-h1w9gbxk	94	40	39	39	CD
cord-017764-h1w9gbxk	94	41	and	and	CC
cord-017764-h1w9gbxk	94	42	40	40	CD
cord-017764-h1w9gbxk	94	43	.	.	.
cord-017764-h1w9gbxk	95	1	The	the	DT
cord-017764-h1w9gbxk	95	2	success	success	NN
cord-017764-h1w9gbxk	95	3	of	of	IN
cord-017764-h1w9gbxk	95	4	this	this	DT
cord-017764-h1w9gbxk	95	5	design	design	NN
cord-017764-h1w9gbxk	95	6	strategy	strategy	NN
cord-017764-h1w9gbxk	95	7	is	be	VBZ
cord-017764-h1w9gbxk	95	8	readily	readily	RB
cord-017764-h1w9gbxk	95	9	apparent	apparent	JJ
cord-017764-h1w9gbxk	95	10	since	since	IN
cord-017764-h1w9gbxk	95	11	both	both	CC
cord-017764-h1w9gbxk	95	12	43	43	CD
cord-017764-h1w9gbxk	95	13	and	and	CC
cord-017764-h1w9gbxk	95	14	44	44	CD
cord-017764-h1w9gbxk	95	15	are	be	VBP
cord-017764-h1w9gbxk	95	16	exquisitely	exquisitely	RB
cord-017764-h1w9gbxk	95	17	potent	potent	JJ
cord-017764-h1w9gbxk	95	18	HCV	HCV	NNP
cord-017764-h1w9gbxk	95	19	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	95	20	agents	agent	NNS
cord-017764-h1w9gbxk	95	21	with	with	IN
cord-017764-h1w9gbxk	95	22	balanced	balanced	JJ
cord-017764-h1w9gbxk	95	23	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	95	24	and	and	CC
cord-017764-h1w9gbxk	95	25	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	95	26	inhibition	inhibition	NN
cord-017764-h1w9gbxk	95	27	,	,	,
cord-017764-h1w9gbxk	95	28	with	with	IN
cord-017764-h1w9gbxk	95	29	EC	EC	NNP
cord-017764-h1w9gbxk	95	30	50	50	CD
cord-017764-h1w9gbxk	95	31	values	value	NNS
cord-017764-h1w9gbxk	95	32	ranging	range	VBG
cord-017764-h1w9gbxk	95	33	from	from	IN
cord-017764-h1w9gbxk	95	34	7	7	CD
cord-017764-h1w9gbxk	95	35	to	to	IN
cord-017764-h1w9gbxk	95	36	42	42	CD
cord-017764-h1w9gbxk	95	37	pM	pm	NN
cord-017764-h1w9gbxk	96	1	[	[	-LRB-
cord-017764-h1w9gbxk	96	2	4	4	CD
cord-017764-h1w9gbxk	96	3	]	]	-RRB-
cord-017764-h1w9gbxk	96	4	.	.	.
cord-017764-h1w9gbxk	97	1	However	however	RB
cord-017764-h1w9gbxk	97	2	,	,	,
cord-017764-h1w9gbxk	97	3	the	the	DT
cord-017764-h1w9gbxk	97	4	oral	oral	JJ
cord-017764-h1w9gbxk	97	5	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	97	6	and	and	CC
cord-017764-h1w9gbxk	97	7	systemic	systemic	JJ
cord-017764-h1w9gbxk	97	8	exposure	exposure	NN
cord-017764-h1w9gbxk	97	9	of	of	IN
cord-017764-h1w9gbxk	97	10	both	both	DT
cord-017764-h1w9gbxk	97	11	43	43	CD
cord-017764-h1w9gbxk	97	12	and	and	CC
cord-017764-h1w9gbxk	97	13	44	44	CD
cord-017764-h1w9gbxk	97	14	in	in	IN
cord-017764-h1w9gbxk	97	15	the	the	DT
cord-017764-h1w9gbxk	97	16	rat	rat	NN
cord-017764-h1w9gbxk	97	17	were	be	VBD
cord-017764-h1w9gbxk	97	18	poor	poor	JJ
cord-017764-h1w9gbxk	97	19	,	,	,
cord-017764-h1w9gbxk	97	20	a	a	DT
cord-017764-h1w9gbxk	97	21	result	result	NN
cord-017764-h1w9gbxk	97	22	attributed	attribute	VBN
cord-017764-h1w9gbxk	97	23	,	,	,
cord-017764-h1w9gbxk	97	24	in	in	IN
cord-017764-h1w9gbxk	97	25	part	part	NN
cord-017764-h1w9gbxk	97	26	,	,	,
cord-017764-h1w9gbxk	97	27	to	to	IN
cord-017764-h1w9gbxk	97	28	the	the	DT
cord-017764-h1w9gbxk	97	29	high	high	JJ
cord-017764-h1w9gbxk	97	30	molecular	molecular	JJ
cord-017764-h1w9gbxk	97	31	weight	weight	NN
cord-017764-h1w9gbxk	97	32	(	(	-LRB-
cord-017764-h1w9gbxk	97	33	747	747	CD
cord-017764-h1w9gbxk	97	34	and	and	CC
cord-017764-h1w9gbxk	97	35	807	807	CD
cord-017764-h1w9gbxk	97	36	Da	Da	NNS
cord-017764-h1w9gbxk	97	37	,	,	,
cord-017764-h1w9gbxk	97	38	respectively	respectively	RB
cord-017764-h1w9gbxk	97	39	)	)	-RRB-
cord-017764-h1w9gbxk	97	40	and	and	CC
cord-017764-h1w9gbxk	97	41	structural	structural	JJ
cord-017764-h1w9gbxk	97	42	composition	composition	NN
cord-017764-h1w9gbxk	97	43	.	.	.
cord-017764-h1w9gbxk	98	1	This	this	DT
cord-017764-h1w9gbxk	98	2	notion	notion	NN
cord-017764-h1w9gbxk	98	3	was	be	VBD
cord-017764-h1w9gbxk	98	4	reinforced	reinforce	VBN
cord-017764-h1w9gbxk	98	5	by	by	IN
cord-017764-h1w9gbxk	98	6	PK	PK	NNP
cord-017764-h1w9gbxk	98	7	studies	study	NNS
cord-017764-h1w9gbxk	98	8	with	with	IN
cord-017764-h1w9gbxk	98	9	the	the	DT
cord-017764-h1w9gbxk	98	10	smaller	small	JJR
cord-017764-h1w9gbxk	98	11	(	(	-LRB-
cord-017764-h1w9gbxk	98	12	MW	MW	NNP
cord-017764-h1w9gbxk	98	13	¼	¼	NNP
cord-017764-h1w9gbxk	98	14	713	713	CD
cord-017764-h1w9gbxk	98	15	)	)	-RRB-
cord-017764-h1w9gbxk	98	16	and	and	CC
cord-017764-h1w9gbxk	98	17	unsymmetrical	unsymmetrical	JJ
cord-017764-h1w9gbxk	98	18	tetrahydrofuran	tetrahydrofuran	NN
cord-017764-h1w9gbxk	98	19	45	45	CD
cord-017764-h1w9gbxk	98	20	which	which	WDT
cord-017764-h1w9gbxk	98	21	divests	divest	VBZ
cord-017764-h1w9gbxk	98	22	of	of	IN
cord-017764-h1w9gbxk	98	23	a	a	DT
cord-017764-h1w9gbxk	98	24	H	h	NN
cord-017764-h1w9gbxk	98	25	-	-	HYPH
cord-017764-h1w9gbxk	98	26	bond	bond	NN
cord-017764-h1w9gbxk	98	27	donor	donor	NN
cord-017764-h1w9gbxk	98	28	.	.	.
cord-017764-h1w9gbxk	99	1	Although	although	IN
cord-017764-h1w9gbxk	99	2	the	the	DT
cord-017764-h1w9gbxk	99	3	oral	oral	JJ
cord-017764-h1w9gbxk	99	4	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	99	5	of	of	IN
cord-017764-h1w9gbxk	99	6	45	45	CD
cord-017764-h1w9gbxk	99	7	was	be	VBD
cord-017764-h1w9gbxk	99	8	low	low	JJ
cord-017764-h1w9gbxk	99	9	in	in	IN
cord-017764-h1w9gbxk	99	10	rodents	rodent	NNS
cord-017764-h1w9gbxk	99	11	(	(	-LRB-
cord-017764-h1w9gbxk	99	12	F	F	NNP
cord-017764-h1w9gbxk	99	13	in	in	IN
cord-017764-h1w9gbxk	99	14	mouse	mouse	NN
cord-017764-h1w9gbxk	99	15	¼	¼	CD
cord-017764-h1w9gbxk	99	16	17	17	CD
cord-017764-h1w9gbxk	99	17	%	%	NN
cord-017764-h1w9gbxk	99	18	,	,	,
cord-017764-h1w9gbxk	99	19	F	F	NNP
cord-017764-h1w9gbxk	99	20	in	in	IN
cord-017764-h1w9gbxk	99	21	rat	rat	NN
cord-017764-h1w9gbxk	99	22	¼	¼	NNP
cord-017764-h1w9gbxk	99	23	6.8	6.8	CD
cord-017764-h1w9gbxk	99	24	%	%	NN
cord-017764-h1w9gbxk	99	25	)	)	-RRB-
cord-017764-h1w9gbxk	99	26	,	,	,
cord-017764-h1w9gbxk	99	27	its	-PRON-	PRP$
cord-017764-h1w9gbxk	99	28	exposure	exposure	NN
cord-017764-h1w9gbxk	99	29	in	in	IN
cord-017764-h1w9gbxk	99	30	the	the	DT
cord-017764-h1w9gbxk	99	31	dog	dog	NN
cord-017764-h1w9gbxk	99	32	was	be	VBD
cord-017764-h1w9gbxk	99	33	much	much	RB
cord-017764-h1w9gbxk	99	34	improved	improve	VBN
cord-017764-h1w9gbxk	99	35	,	,	,
cord-017764-h1w9gbxk	99	36	with	with	IN
cord-017764-h1w9gbxk	99	37	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	99	38	measured	measure	VBN
cord-017764-h1w9gbxk	99	39	at	at	IN
cord-017764-h1w9gbxk	99	40	45	45	CD
cord-017764-h1w9gbxk	99	41	%	%	NN
cord-017764-h1w9gbxk	99	42	.	.	.
cord-017764-h1w9gbxk	100	1	In	in	IN
cord-017764-h1w9gbxk	100	2	an	an	DT
cord-017764-h1w9gbxk	100	3	effort	effort	NN
cord-017764-h1w9gbxk	100	4	to	to	TO
cord-017764-h1w9gbxk	100	5	reduce	reduce	VB
cord-017764-h1w9gbxk	100	6	the	the	DT
cord-017764-h1w9gbxk	100	7	molecular	molecular	JJ
cord-017764-h1w9gbxk	100	8	weight	weight	NN
cord-017764-h1w9gbxk	100	9	of	of	IN
cord-017764-h1w9gbxk	100	10	the	the	DT
cord-017764-h1w9gbxk	100	11	carbamate	carbamate	NN
cord-017764-h1w9gbxk	100	12	44	44	CD
cord-017764-h1w9gbxk	100	13	,	,	,
cord-017764-h1w9gbxk	100	14	the	the	DT
cord-017764-h1w9gbxk	100	15	two	two	CD
cord-017764-h1w9gbxk	100	16	aromatic	aromatic	JJ
cord-017764-h1w9gbxk	100	17	rings	ring	NNS
cord-017764-h1w9gbxk	100	18	of	of	IN
cord-017764-h1w9gbxk	100	19	the	the	DT
cord-017764-h1w9gbxk	100	20	phenyl	phenyl	NNP
cord-017764-h1w9gbxk	100	21	glycine	glycine	NN
cord-017764-h1w9gbxk	100	22	moiety	moiety	NN
cord-017764-h1w9gbxk	100	23	were	be	VBD
cord-017764-h1w9gbxk	100	24	curtailed	curtail	VBN
cord-017764-h1w9gbxk	100	25	to	to	IN
cord-017764-h1w9gbxk	100	26	isopropyl	isopropyl	NN
cord-017764-h1w9gbxk	100	27	substituents	substituent	NNS
cord-017764-h1w9gbxk	100	28	affording	afford	VBG
cord-017764-h1w9gbxk	100	29	the	the	DT
cord-017764-h1w9gbxk	100	30	D	d	NN
cord-017764-h1w9gbxk	100	31	-	-	HYPH
cord-017764-h1w9gbxk	100	32	valine	valine	NN
cord-017764-h1w9gbxk	100	33	derivative	derivative	NN
cord-017764-h1w9gbxk	100	34	46	46	CD
cord-017764-h1w9gbxk	100	35	.	.	.
cord-017764-h1w9gbxk	101	1	However	however	RB
cord-017764-h1w9gbxk	101	2	,	,	,
cord-017764-h1w9gbxk	101	3	this	this	DT
cord-017764-h1w9gbxk	101	4	structural	structural	JJ
cord-017764-h1w9gbxk	101	5	modification	modification	NN
cord-017764-h1w9gbxk	101	6	resulted	result	VBD
cord-017764-h1w9gbxk	101	7	in	in	IN
cord-017764-h1w9gbxk	101	8	a	a	DT
cord-017764-h1w9gbxk	101	9	significant	significant	JJ
cord-017764-h1w9gbxk	101	10	reduction	reduction	NN
cord-017764-h1w9gbxk	101	11	in	in	IN
cord-017764-h1w9gbxk	101	12	potency	potency	NN
cord-017764-h1w9gbxk	101	13	toward	toward	IN
cord-017764-h1w9gbxk	101	14	both	both	CC
cord-017764-h1w9gbxk	101	15	HCV	HCV	NNP
cord-017764-h1w9gbxk	101	16	genotypes	genotype	NNS
cord-017764-h1w9gbxk	101	17	,	,	,
cord-017764-h1w9gbxk	101	18	with	with	IN
cord-017764-h1w9gbxk	101	19	the	the	DT
cord-017764-h1w9gbxk	101	20	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	101	21	inhibition	inhibition	NN
cord-017764-h1w9gbxk	101	22	particularly	particularly	RB
cord-017764-h1w9gbxk	101	23	sensitive	sensitive	JJ
cord-017764-h1w9gbxk	101	24	,	,	,
cord-017764-h1w9gbxk	101	25	eroding	erode	VBG
cord-017764-h1w9gbxk	101	26	by	by	IN
cord-017764-h1w9gbxk	101	27	44,000-fold	44,000-fold	CD
cord-017764-h1w9gbxk	101	28	.	.	.
cord-017764-h1w9gbxk	102	1	This	this	DT
cord-017764-h1w9gbxk	102	2	SAR	SAR	NNP
cord-017764-h1w9gbxk	102	3	observation	observation	NN
cord-017764-h1w9gbxk	102	4	took	take	VBD
cord-017764-h1w9gbxk	102	5	some	some	DT
cord-017764-h1w9gbxk	102	6	time	time	NN
cord-017764-h1w9gbxk	102	7	to	to	TO
cord-017764-h1w9gbxk	102	8	understand	understand	VB
cord-017764-h1w9gbxk	102	9	and	and	CC
cord-017764-h1w9gbxk	102	10	was	be	VBD
cord-017764-h1w9gbxk	102	11	resolved	resolve	VBN
cord-017764-h1w9gbxk	102	12	only	only	RB
cord-017764-h1w9gbxk	102	13	after	after	IN
cord-017764-h1w9gbxk	102	14	further	further	JJ
cord-017764-h1w9gbxk	102	15	study	study	NN
cord-017764-h1w9gbxk	102	16	of	of	IN
cord-017764-h1w9gbxk	102	17	the	the	DT
cord-017764-h1w9gbxk	102	18	chemotype	chemotype	NN
cord-017764-h1w9gbxk	102	19	,	,	,
cord-017764-h1w9gbxk	102	20	which	which	WDT
cord-017764-h1w9gbxk	102	21	revealed	reveal	VBD
cord-017764-h1w9gbxk	102	22	that	that	IN
cord-017764-h1w9gbxk	102	23	the	the	DT
cord-017764-h1w9gbxk	102	24	preferred	preferred	JJ
cord-017764-h1w9gbxk	102	25	absolute	absolute	JJ
cord-017764-h1w9gbxk	102	26	configuration	configuration	NN
cord-017764-h1w9gbxk	102	27	of	of	IN
cord-017764-h1w9gbxk	102	28	the	the	DT
cord-017764-h1w9gbxk	102	29	alkyl	alkyl	JJ
cord-017764-h1w9gbxk	102	30	-	-	HYPH
cord-017764-h1w9gbxk	102	31	glycine	glycine	NN
cord-017764-h1w9gbxk	102	32	caps	cap	NNS
cord-017764-h1w9gbxk	102	33	was	be	VBD
cord-017764-h1w9gbxk	102	34	the	the	DT
cord-017764-h1w9gbxk	102	35	opposite	opposite	NN
cord-017764-h1w9gbxk	102	36	of	of	IN
cord-017764-h1w9gbxk	102	37	that	that	DT
cord-017764-h1w9gbxk	102	38	of	of	IN
cord-017764-h1w9gbxk	102	39	the	the	DT
cord-017764-h1w9gbxk	102	40	aryl	aryl	NN
cord-017764-h1w9gbxk	102	41	-	-	HYPH
cord-017764-h1w9gbxk	102	42	glycine	glycine	NN
cord-017764-h1w9gbxk	102	43	caps	cap	NNS
cord-017764-h1w9gbxk	102	44	.	.	.
cord-017764-h1w9gbxk	103	1	The	the	DT
cord-017764-h1w9gbxk	103	2	initial	initial	JJ
cord-017764-h1w9gbxk	103	3	observation	observation	NN
cord-017764-h1w9gbxk	103	4	in	in	IN
cord-017764-h1w9gbxk	103	5	this	this	DT
cord-017764-h1w9gbxk	103	6	direction	direction	NN
cord-017764-h1w9gbxk	103	7	was	be	VBD
cord-017764-h1w9gbxk	103	8	made	make	VBN
cord-017764-h1w9gbxk	103	9	when	when	WRB
cord-017764-h1w9gbxk	103	10	the	the	DT
cord-017764-h1w9gbxk	103	11	tetrahydrofuran	tetrahydrofuran	NN
cord-017764-h1w9gbxk	103	12	ring	ring	NN
cord-017764-h1w9gbxk	103	13	of	of	IN
cord-017764-h1w9gbxk	103	14	45	45	CD
cord-017764-h1w9gbxk	103	15	was	be	VBD
cord-017764-h1w9gbxk	103	16	replaced	replace	VBN
cord-017764-h1w9gbxk	103	17	with	with	IN
cord-017764-h1w9gbxk	103	18	L	l	NN
cord-017764-h1w9gbxk	103	19	-	-	HYPH
cord-017764-h1w9gbxk	103	20	alanine	alanine	NNP
cord-017764-h1w9gbxk	103	21	to	to	TO
cord-017764-h1w9gbxk	103	22	provide	provide	VB
cord-017764-h1w9gbxk	103	23	47	47	CD
cord-017764-h1w9gbxk	103	24	,	,	,
cord-017764-h1w9gbxk	103	25	which	which	WDT
cord-017764-h1w9gbxk	103	26	restored	restore	VBD
cord-017764-h1w9gbxk	103	27	potency	potency	NN
cord-017764-h1w9gbxk	103	28	to	to	IN
cord-017764-h1w9gbxk	103	29	sub	sub	JJ
cord-017764-h1w9gbxk	103	30	-	-	JJ
cord-017764-h1w9gbxk	103	31	nanomolar	nanomolar	JJ
cord-017764-h1w9gbxk	103	32	levels	level	NNS
cord-017764-h1w9gbxk	103	33	.	.	.
cord-017764-h1w9gbxk	104	1	In	in	IN
cord-017764-h1w9gbxk	104	2	an	an	DT
cord-017764-h1w9gbxk	104	3	observation	observation	NN
cord-017764-h1w9gbxk	104	4	that	that	WDT
cord-017764-h1w9gbxk	104	5	proved	prove	VBD
cord-017764-h1w9gbxk	104	6	to	to	TO
cord-017764-h1w9gbxk	104	7	be	be	VB
cord-017764-h1w9gbxk	104	8	pivotal	pivotal	JJ
cord-017764-h1w9gbxk	104	9	,	,	,
cord-017764-h1w9gbxk	104	10	the	the	DT
cord-017764-h1w9gbxk	104	11	symmetrical	symmetrical	JJ
cord-017764-h1w9gbxk	104	12	alanine	alanine	NN
cord-017764-h1w9gbxk	104	13	derivative	derivative	NN
cord-017764-h1w9gbxk	104	14	48	48	CD
cord-017764-h1w9gbxk	104	15	performed	perform	VBD
cord-017764-h1w9gbxk	104	16	similarly	similarly	RB
cord-017764-h1w9gbxk	104	17	,	,	,
cord-017764-h1w9gbxk	104	18	and	and	CC
cord-017764-h1w9gbxk	104	19	further	further	JJ
cord-017764-h1w9gbxk	104	20	optimization	optimization	NN
cord-017764-h1w9gbxk	104	21	of	of	IN
cord-017764-h1w9gbxk	104	22	the	the	DT
cord-017764-h1w9gbxk	104	23	amino	amino	NN
cord-017764-h1w9gbxk	104	24	acid	acid	NN
cord-017764-h1w9gbxk	104	25	appendage	appendage	NN
cord-017764-h1w9gbxk	104	26	led	lead	VBD
cord-017764-h1w9gbxk	104	27	to	to	IN
cord-017764-h1w9gbxk	104	28	the	the	DT
cord-017764-h1w9gbxk	104	29	discovery	discovery	NN
cord-017764-h1w9gbxk	104	30	of	of	IN
cord-017764-h1w9gbxk	104	31	the	the	DT
cord-017764-h1w9gbxk	104	32	bis	bis	NNP
cord-017764-h1w9gbxk	104	33	-	-	HYPH
cord-017764-h1w9gbxk	104	34	L	l	NN
cord-017764-h1w9gbxk	104	35	-	-	HYPH
cord-017764-h1w9gbxk	104	36	valine	valine	NN
cord-017764-h1w9gbxk	104	37	derivative	derivative	NN
cord-017764-h1w9gbxk	104	38	1	1	CD
cord-017764-h1w9gbxk	104	39	,	,	,
cord-017764-h1w9gbxk	104	40	an	an	DT
cord-017764-h1w9gbxk	104	41	exercise	exercise	NN
cord-017764-h1w9gbxk	104	42	that	that	WDT
cord-017764-h1w9gbxk	104	43	also	also	RB
cord-017764-h1w9gbxk	104	44	included	include	VBD
cord-017764-h1w9gbxk	104	45	assessing	assess	VBG
cord-017764-h1w9gbxk	104	46	the	the	DT
cord-017764-h1w9gbxk	104	47	potential	potential	NN
cord-017764-h1w9gbxk	104	48	of	of	IN
cord-017764-h1w9gbxk	104	49	unsymmetrical	unsymmetrical	JJ
cord-017764-h1w9gbxk	104	50	derivatives	derivative	NNS
cord-017764-h1w9gbxk	104	51	.	.	.
cord-017764-h1w9gbxk	105	1	The	the	DT
cord-017764-h1w9gbxk	105	2	decision	decision	NN
cord-017764-h1w9gbxk	105	3	to	to	TO
cord-017764-h1w9gbxk	105	4	advance	advance	VB
cord-017764-h1w9gbxk	105	5	1	1	CD
cord-017764-h1w9gbxk	105	6	into	into	IN
cord-017764-h1w9gbxk	105	7	IND	IND	NNP
cord-017764-h1w9gbxk	105	8	-	-	HYPH
cord-017764-h1w9gbxk	105	9	enabling	enable	VBG
cord-017764-h1w9gbxk	105	10	toxicology	toxicology	NN
cord-017764-h1w9gbxk	105	11	evaluation	evaluation	NN
cord-017764-h1w9gbxk	105	12	was	be	VBD
cord-017764-h1w9gbxk	105	13	taken	take	VBN
cord-017764-h1w9gbxk	105	14	after	after	IN
cord-017764-h1w9gbxk	105	15	a	a	DT
cord-017764-h1w9gbxk	105	16	careful	careful	JJ
cord-017764-h1w9gbxk	105	17	comparison	comparison	NN
cord-017764-h1w9gbxk	105	18	with	with	IN
cord-017764-h1w9gbxk	105	19	49	49	CD
cord-017764-h1w9gbxk	105	20	,	,	,
cord-017764-h1w9gbxk	105	21	an	an	DT
cord-017764-h1w9gbxk	105	22	analogue	analogue	NN
cord-017764-h1w9gbxk	105	23	with	with	IN
cord-017764-h1w9gbxk	105	24	two	two	CD
cord-017764-h1w9gbxk	105	25	changes	change	NNS
cord-017764-h1w9gbxk	105	26	to	to	IN
cord-017764-h1w9gbxk	105	27	the	the	DT
cord-017764-h1w9gbxk	105	28	periphery	periphery	NN
cord-017764-h1w9gbxk	105	29	that	that	WDT
cord-017764-h1w9gbxk	105	30	demonstrated	demonstrate	VBD
cord-017764-h1w9gbxk	105	31	similar	similar	JJ
cord-017764-h1w9gbxk	105	32	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	105	33	properties	property	NNS
cord-017764-h1w9gbxk	105	34	to	to	IN
cord-017764-h1w9gbxk	105	35	1	1	CD
cord-017764-h1w9gbxk	105	36	(	(	-LRB-
cord-017764-h1w9gbxk	105	37	Table	table	NN
cord-017764-h1w9gbxk	105	38	2	2	CD
cord-017764-h1w9gbxk	105	39	)	)	-RRB-
cord-017764-h1w9gbxk	106	1	but	but	CC
cord-017764-h1w9gbxk	106	2	a	a	DT
cord-017764-h1w9gbxk	106	3	different	different	JJ
cord-017764-h1w9gbxk	106	4	PK	PK	NNP
cord-017764-h1w9gbxk	106	5	profile	profile	NN
cord-017764-h1w9gbxk	106	6	(	(	-LRB-
cord-017764-h1w9gbxk	106	7	Table	table	NN
cord-017764-h1w9gbxk	106	8	3	3	CD
cord-017764-h1w9gbxk	106	9	)	)	-RRB-
cord-017764-h1w9gbxk	106	10	.	.	.
cord-017764-h1w9gbxk	107	1	The	the	DT
cord-017764-h1w9gbxk	107	2	decision	decision	NN
cord-017764-h1w9gbxk	107	3	to	to	TO
cord-017764-h1w9gbxk	107	4	select	select	VB
cord-017764-h1w9gbxk	107	5	1	1	CD
cord-017764-h1w9gbxk	107	6	for	for	IN
cord-017764-h1w9gbxk	107	7	development	development	NN
cord-017764-h1w9gbxk	107	8	rather	rather	RB
cord-017764-h1w9gbxk	107	9	49	49	CD
cord-017764-h1w9gbxk	107	10	was	be	VBD
cord-017764-h1w9gbxk	107	11	based	base	VBN
cord-017764-h1w9gbxk	107	12	on	on	IN
cord-017764-h1w9gbxk	107	13	the	the	DT
cord-017764-h1w9gbxk	107	14	observation	observation	NN
cord-017764-h1w9gbxk	107	15	of	of	IN
cord-017764-h1w9gbxk	107	16	a	a	DT
cord-017764-h1w9gbxk	107	17	twofold	twofold	JJ
cord-017764-h1w9gbxk	107	18	accumulation	accumulation	NN
cord-017764-h1w9gbxk	107	19	of	of	IN
cord-017764-h1w9gbxk	107	20	the	the	DT
cord-017764-h1w9gbxk	107	21	latter	latter	JJ
cord-017764-h1w9gbxk	107	22	compound	compound	NN
cord-017764-h1w9gbxk	107	23	in	in	IN
cord-017764-h1w9gbxk	107	24	the	the	DT
cord-017764-h1w9gbxk	107	25	plasma	plasma	NN
cord-017764-h1w9gbxk	107	26	,	,	,
cord-017764-h1w9gbxk	107	27	livers	liver	NNS
cord-017764-h1w9gbxk	107	28	,	,	,
cord-017764-h1w9gbxk	107	29	and	and	CC
cord-017764-h1w9gbxk	107	30	hearts	heart	NNS
cord-017764-h1w9gbxk	107	31	of	of	IN
cord-017764-h1w9gbxk	107	32	mice	mouse	NNS
cord-017764-h1w9gbxk	107	33	after	after	IN
cord-017764-h1w9gbxk	107	34	4	4	CD
cord-017764-h1w9gbxk	107	35	days	day	NNS
cord-017764-h1w9gbxk	107	36	of	of	IN
cord-017764-h1w9gbxk	107	37	daily	daily	JJ
cord-017764-h1w9gbxk	107	38	drug	drug	NNP
cord-017764-h1w9gbxk	107	39	administration	administration	NNP
cord-017764-h1w9gbxk	107	40	which	which	WDT
cord-017764-h1w9gbxk	107	41	occurred	occur	VBD
cord-017764-h1w9gbxk	107	42	at	at	IN
cord-017764-h1w9gbxk	107	43	all	all	DT
cord-017764-h1w9gbxk	107	44	of	of	IN
cord-017764-h1w9gbxk	107	45	the	the	DT
cord-017764-h1w9gbxk	107	46	dose	dose	NN
cord-017764-h1w9gbxk	107	47	levels	level	NNS
cord-017764-h1w9gbxk	107	48	(	(	-LRB-
cord-017764-h1w9gbxk	107	49	15	15	CD
cord-017764-h1w9gbxk	107	50	,	,	,
cord-017764-h1w9gbxk	107	51	50	50	CD
cord-017764-h1w9gbxk	107	52	,	,	,
cord-017764-h1w9gbxk	107	53	and	and	CC
cord-017764-h1w9gbxk	107	54	100	100	CD
cord-017764-h1w9gbxk	107	55	mg	mg	NNP
cord-017764-h1w9gbxk	107	56	/	/	SYM
cord-017764-h1w9gbxk	107	57	kg	kg	NNP
cord-017764-h1w9gbxk	107	58	)	)	-RRB-
cord-017764-h1w9gbxk	107	59	examined	examine	VBD
cord-017764-h1w9gbxk	107	60	.	.	.
cord-017764-h1w9gbxk	108	1	The	the	DT
cord-017764-h1w9gbxk	108	2	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	108	3	profiles	profile	NNS
cord-017764-h1w9gbxk	108	4	of	of	IN
cord-017764-h1w9gbxk	108	5	1	1	CD
cord-017764-h1w9gbxk	108	6	and	and	CC
cord-017764-h1w9gbxk	108	7	49	49	CD
cord-017764-h1w9gbxk	108	8	toward	toward	IN
cord-017764-h1w9gbxk	108	9	wild	wild	JJ
cord-017764-h1w9gbxk	108	10	-	-	HYPH
cord-017764-h1w9gbxk	108	11	type	type	NN
cord-017764-h1w9gbxk	108	12	and	and	CC
cord-017764-h1w9gbxk	108	13	hybrid	hybrid	JJ
cord-017764-h1w9gbxk	108	14	replicons	replicon	NNS
cord-017764-h1w9gbxk	108	15	representing	represent	VBG
cord-017764-h1w9gbxk	108	16	all	all	DT
cord-017764-h1w9gbxk	108	17	of	of	IN
cord-017764-h1w9gbxk	108	18	the	the	DT
cord-017764-h1w9gbxk	108	19	genotypes	genotype	NNS
cord-017764-h1w9gbxk	108	20	and	and	CC
cord-017764-h1w9gbxk	108	21	subtypes	subtype	NNS
cord-017764-h1w9gbxk	108	22	that	that	WDT
cord-017764-h1w9gbxk	108	23	were	be	VBD
cord-017764-h1w9gbxk	108	24	available	available	JJ
cord-017764-h1w9gbxk	108	25	at	at	IN
cord-017764-h1w9gbxk	108	26	the	the	DT
cord-017764-h1w9gbxk	108	27	time	time	NN
cord-017764-h1w9gbxk	108	28	are	be	VBP
cord-017764-h1w9gbxk	108	29	summarized	summarize	VBN
cord-017764-h1w9gbxk	108	30	in	in	IN
cord-017764-h1w9gbxk	108	31	Table	Table	NNP
cord-017764-h1w9gbxk	108	32	2	2	CD
cord-017764-h1w9gbxk	108	33	[	[	-LRB-
cord-017764-h1w9gbxk	108	34	1	1	CD
cord-017764-h1w9gbxk	108	35	]	]	-RRB-
cord-017764-h1w9gbxk	108	36	[	[	-LRB-
cord-017764-h1w9gbxk	108	37	2	2	CD
cord-017764-h1w9gbxk	108	38	]	]	-RRB-
cord-017764-h1w9gbxk	108	39	[	[	-LRB-
cord-017764-h1w9gbxk	108	40	3	3	CD
cord-017764-h1w9gbxk	108	41	]	]	-RRB-
cord-017764-h1w9gbxk	108	42	[	[	-LRB-
cord-017764-h1w9gbxk	108	43	4	4	CD
cord-017764-h1w9gbxk	108	44	]	]	-RRB-
cord-017764-h1w9gbxk	108	45	[	[	-LRB-
cord-017764-h1w9gbxk	108	46	37	37	CD
cord-017764-h1w9gbxk	108	47	]	]	-RRB-
cord-017764-h1w9gbxk	108	48	[	[	-LRB-
cord-017764-h1w9gbxk	108	49	38	38	CD
cord-017764-h1w9gbxk	108	50	]	]	-RRB-
cord-017764-h1w9gbxk	108	51	[	[	-LRB-
cord-017764-h1w9gbxk	108	52	39	39	CD
cord-017764-h1w9gbxk	108	53	]	]	-RRB-
cord-017764-h1w9gbxk	108	54	[	[	-LRB-
cord-017764-h1w9gbxk	108	55	40	40	CD
cord-017764-h1w9gbxk	108	56	]	]	-RRB-
cord-017764-h1w9gbxk	108	57	.	.	.
cord-017764-h1w9gbxk	109	1	Adding	add	VBG
cord-017764-h1w9gbxk	109	2	to	to	IN
cord-017764-h1w9gbxk	109	3	confidence	confidence	NN
cord-017764-h1w9gbxk	109	4	in	in	IN
cord-017764-h1w9gbxk	109	5	the	the	DT
cord-017764-h1w9gbxk	109	6	potential	potential	NN
cord-017764-h1w9gbxk	109	7	of	of	IN
cord-017764-h1w9gbxk	109	8	1	1	CD
cord-017764-h1w9gbxk	109	9	as	as	IN
cord-017764-h1w9gbxk	109	10	it	-PRON-	PRP
cord-017764-h1w9gbxk	109	11	negotiated	negotiate	VBD
cord-017764-h1w9gbxk	109	12	the	the	DT
cord-017764-h1w9gbxk	109	13	development	development	NN
cord-017764-h1w9gbxk	109	14	path	path	NN
cord-017764-h1w9gbxk	109	15	toward	toward	IN
cord-017764-h1w9gbxk	109	16	clinical	clinical	JJ
cord-017764-h1w9gbxk	109	17	evaluation	evaluation	NN
cord-017764-h1w9gbxk	109	18	was	be	VBD
cord-017764-h1w9gbxk	109	19	the	the	DT
cord-017764-h1w9gbxk	109	20	potent	potent	JJ
cord-017764-h1w9gbxk	109	21	inhibition	inhibition	NN
cord-017764-h1w9gbxk	109	22	observed	observe	VBD
cord-017764-h1w9gbxk	109	23	in	in	IN
cord-017764-h1w9gbxk	109	24	a	a	DT
cord-017764-h1w9gbxk	109	25	newly	newly	RB
cord-017764-h1w9gbxk	109	26	established	establish	VBN
cord-017764-h1w9gbxk	109	27	GT-2a	gt-2a	NN
cord-017764-h1w9gbxk	109	28	JFH	JFH	NNP
cord-017764-h1w9gbxk	109	29	-	-	HYPH
cord-017764-h1w9gbxk	109	30	replicating	replicate	VBG
cord-017764-h1w9gbxk	109	31	virus	virus	NN
cord-017764-h1w9gbxk	109	32	assay	assay	NN
cord-017764-h1w9gbxk	109	33	.	.	.
cord-017764-h1w9gbxk	110	1	The	the	DT
cord-017764-h1w9gbxk	110	2	EC	EC	NNP
cord-017764-h1w9gbxk	110	3	50	50	CD
cord-017764-h1w9gbxk	110	4	value	value	NN
cord-017764-h1w9gbxk	110	5	of	of	IN
cord-017764-h1w9gbxk	110	6	28	28	CD
cord-017764-h1w9gbxk	110	7	pM	pm	NN
cord-017764-h1w9gbxk	110	8	in	in	IN
cord-017764-h1w9gbxk	110	9	this	this	DT
cord-017764-h1w9gbxk	110	10	assay	assay	NN
cord-017764-h1w9gbxk	110	11	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	110	12	a	a	DT
cord-017764-h1w9gbxk	110	13	good	good	JJ
cord-017764-h1w9gbxk	110	14	correlation	correlation	NN
cord-017764-h1w9gbxk	110	15	with	with	IN
cord-017764-h1w9gbxk	110	16	the	the	DT
cord-017764-h1w9gbxk	110	17	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	110	18	potency	potency	NN
cord-017764-h1w9gbxk	110	19	toward	toward	IN
cord-017764-h1w9gbxk	110	20	the	the	DT
cord-017764-h1w9gbxk	110	21	GT-2a	gt-2a	NN
cord-017764-h1w9gbxk	110	22	JFH	JFH	NNP
cord-017764-h1w9gbxk	110	23	replicon	replicon	NN
cord-017764-h1w9gbxk	110	24	[	[	-LRB-
cord-017764-h1w9gbxk	110	25	1	1	CD
cord-017764-h1w9gbxk	110	26	]	]	-RRB-
cord-017764-h1w9gbxk	110	27	[	[	-LRB-
cord-017764-h1w9gbxk	110	28	2	2	CD
cord-017764-h1w9gbxk	110	29	]	]	-RRB-
cord-017764-h1w9gbxk	110	30	[	[	-LRB-
cord-017764-h1w9gbxk	110	31	3	3	CD
cord-017764-h1w9gbxk	110	32	]	]	-RRB-
cord-017764-h1w9gbxk	110	33	[	[	-LRB-
cord-017764-h1w9gbxk	110	34	4	4	CD
cord-017764-h1w9gbxk	110	35	]	]	-RRB-
cord-017764-h1w9gbxk	110	36	.	.	.
cord-017764-h1w9gbxk	111	1	The	the	DT
cord-017764-h1w9gbxk	111	2	pharmacokinetic	pharmacokinetic	JJ
cord-017764-h1w9gbxk	111	3	parameters	parameter	NNS
cord-017764-h1w9gbxk	111	4	of	of	IN
cord-017764-h1w9gbxk	111	5	1	1	CD
cord-017764-h1w9gbxk	111	6	and	and	CC
cord-017764-h1w9gbxk	111	7	49	49	CD
cord-017764-h1w9gbxk	111	8	in	in	IN
cord-017764-h1w9gbxk	111	9	rat	rat	NN
cord-017764-h1w9gbxk	111	10	,	,	,
cord-017764-h1w9gbxk	111	11	dog	dog	NN
cord-017764-h1w9gbxk	111	12	,	,	,
cord-017764-h1w9gbxk	111	13	and	and	CC
cord-017764-h1w9gbxk	111	14	cynomolgus	cynomolgus	NNP
cord-017764-h1w9gbxk	111	15	monkey	monkey	NN
cord-017764-h1w9gbxk	111	16	are	be	VBP
cord-017764-h1w9gbxk	111	17	compiled	compile	VBN
cord-017764-h1w9gbxk	111	18	in	in	IN
cord-017764-h1w9gbxk	111	19	Table	Table	NNP
cord-017764-h1w9gbxk	111	20	3	3	CD
cord-017764-h1w9gbxk	111	21	and	and	CC
cord-017764-h1w9gbxk	111	22	demonstrate	demonstrate	VB
cord-017764-h1w9gbxk	111	23	good	good	JJ
cord-017764-h1w9gbxk	111	24	systemic	systemic	JJ
cord-017764-h1w9gbxk	111	25	exposure	exposure	NN
cord-017764-h1w9gbxk	111	26	following	follow	VBG
cord-017764-h1w9gbxk	111	27	oral	oral	JJ
cord-017764-h1w9gbxk	111	28	administration	administration	NN
cord-017764-h1w9gbxk	111	29	,	,	,
cord-017764-h1w9gbxk	111	30	with	with	IN
cord-017764-h1w9gbxk	111	31	the	the	DT
cord-017764-h1w9gbxk	111	32	drug	drug	NN
cord-017764-h1w9gbxk	111	33	concentration	concentration	NN
cord-017764-h1w9gbxk	111	34	measured	measure	VBN
cord-017764-h1w9gbxk	111	35	at	at	IN
cord-017764-h1w9gbxk	111	36	24	24	CD
cord-017764-h1w9gbxk	111	37	h	h	NN
cord-017764-h1w9gbxk	111	38	post	post	NN
cord-017764-h1w9gbxk	111	39	-	-	JJ
cord-017764-h1w9gbxk	111	40	dose	dose	JJ
cord-017764-h1w9gbxk	111	41	well	well	RB
cord-017764-h1w9gbxk	111	42	in	in	IN
cord-017764-h1w9gbxk	111	43	excess	excess	NN
cord-017764-h1w9gbxk	111	44	of	of	IN
cord-017764-h1w9gbxk	111	45	the	the	DT
cord-017764-h1w9gbxk	111	46	EC	EC	NNP
cord-017764-h1w9gbxk	111	47	50	50	CD
cord-017764-h1w9gbxk	111	48	values	value	NNS
cord-017764-h1w9gbxk	111	49	for	for	IN
cord-017764-h1w9gbxk	111	50	the	the	DT
cord-017764-h1w9gbxk	111	51	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	111	52	and	and	CC
cord-017764-h1w9gbxk	111	53	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	111	54	replicons	replicon	NNS
cord-017764-h1w9gbxk	111	55	and	and	CC
cord-017764-h1w9gbxk	111	56	the	the	DT
cord-017764-h1w9gbxk	111	57	proteinbinding	proteinbinding	NN
cord-017764-h1w9gbxk	111	58	-	-	HYPH
cord-017764-h1w9gbxk	111	59	adjusted	adjust	VBN
cord-017764-h1w9gbxk	111	60	EC	EC	NNP
cord-017764-h1w9gbxk	111	61	90	90	CD
cord-017764-h1w9gbxk	111	62	value	value	NN
cord-017764-h1w9gbxk	111	63	of	of	IN
cord-017764-h1w9gbxk	111	64	383	383	CD
cord-017764-h1w9gbxk	111	65	pM	pm	NN
cord-017764-h1w9gbxk	111	66	determined	determine	VBN
cord-017764-h1w9gbxk	111	67	for	for	IN
cord-017764-h1w9gbxk	111	68	the	the	DT
cord-017764-h1w9gbxk	111	69	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	111	70	replicon	replicon	NN
cord-017764-h1w9gbxk	111	71	.	.	.
cord-017764-h1w9gbxk	112	1	More	more	RBR
cord-017764-h1w9gbxk	112	2	importantly	importantly	RB
cord-017764-h1w9gbxk	112	3	,	,	,
cord-017764-h1w9gbxk	112	4	target	target	VB
cord-017764-h1w9gbxk	112	5	organ	organ	NN
cord-017764-h1w9gbxk	112	6	exposure	exposure	NN
cord-017764-h1w9gbxk	112	7	was	be	VBD
cord-017764-h1w9gbxk	112	8	also	also	RB
cord-017764-h1w9gbxk	112	9	demonstrated	demonstrate	VBN
cord-017764-h1w9gbxk	112	10	,	,	,
cord-017764-h1w9gbxk	112	11	with	with	IN
cord-017764-h1w9gbxk	112	12	liver	liver	NN
cord-017764-h1w9gbxk	112	13	levels	level	NNS
cord-017764-h1w9gbxk	112	14	of	of	IN
cord-017764-h1w9gbxk	112	15	103	103	CD
cord-017764-h1w9gbxk	112	16	nM	nm	CD
cord-017764-h1w9gbxk	112	17	measured	measure	VBN
cord-017764-h1w9gbxk	112	18	in	in	IN
cord-017764-h1w9gbxk	112	19	the	the	DT
cord-017764-h1w9gbxk	112	20	rat	rat	NN
cord-017764-h1w9gbxk	112	21	24	24	CD
cord-017764-h1w9gbxk	112	22	h	h	NN
cord-017764-h1w9gbxk	112	23	following	follow	VBG
cord-017764-h1w9gbxk	112	24	a	a	DT
cord-017764-h1w9gbxk	112	25	5	5	CD
cord-017764-h1w9gbxk	112	26	mg	mg	NNP
cord-017764-h1w9gbxk	112	27	/	/	SYM
cord-017764-h1w9gbxk	112	28	kg	kg	NN
cord-017764-h1w9gbxk	112	29	dose	dose	NN
cord-017764-h1w9gbxk	112	30	of	of	IN
cord-017764-h1w9gbxk	112	31	1	1	CD
cord-017764-h1w9gbxk	112	32	,	,	,
cord-017764-h1w9gbxk	112	33	a	a	DT
cord-017764-h1w9gbxk	112	34	concentration	concentration	NN
cord-017764-h1w9gbxk	112	35	that	that	WDT
cord-017764-h1w9gbxk	112	36	was	be	VBD
cord-017764-h1w9gbxk	112	37	fivefold	fivefold	RB
cord-017764-h1w9gbxk	112	38	higher	high	JJR
cord-017764-h1w9gbxk	112	39	than	than	IN
cord-017764-h1w9gbxk	112	40	that	that	DT
cord-017764-h1w9gbxk	112	41	in	in	IN
cord-017764-h1w9gbxk	112	42	plasma	plasma	NN
cord-017764-h1w9gbxk	112	43	.	.	.
cord-017764-h1w9gbxk	113	1	The	the	DT
cord-017764-h1w9gbxk	113	2	favorable	favorable	JJ
cord-017764-h1w9gbxk	113	3	absorption	absorption	NN
cord-017764-h1w9gbxk	113	4	properties	property	NNS
cord-017764-h1w9gbxk	113	5	of	of	IN
cord-017764-h1w9gbxk	113	6	1	1	CD
cord-017764-h1w9gbxk	113	7	have	have	VBP
cord-017764-h1w9gbxk	113	8	been	be	VBN
cord-017764-h1w9gbxk	113	9	attributed	attribute	VBN
cord-017764-h1w9gbxk	113	10	,	,	,
cord-017764-h1w9gbxk	113	11	in	in	IN
cord-017764-h1w9gbxk	113	12	part	part	NN
cord-017764-h1w9gbxk	113	13	,	,	,
cord-017764-h1w9gbxk	113	14	to	to	IN
cord-017764-h1w9gbxk	113	15	the	the	DT
cord-017764-h1w9gbxk	113	16	formation	formation	NN
cord-017764-h1w9gbxk	113	17	of	of	IN
cord-017764-h1w9gbxk	113	18	an	an	DT
cord-017764-h1w9gbxk	113	19	intramolecular	intramolecular	JJ
cord-017764-h1w9gbxk	113	20	H	h	NN
cord-017764-h1w9gbxk	113	21	-	-	HYPH
cord-017764-h1w9gbxk	113	22	bond	bond	NN
cord-017764-h1w9gbxk	113	23	between	between	IN
cord-017764-h1w9gbxk	113	24	the	the	DT
cord-017764-h1w9gbxk	113	25	carbamate	carbamate	NN
cord-017764-h1w9gbxk	113	26	C¼O	C¼O	NNP
cord-017764-h1w9gbxk	113	27	and	and	CC
cord-017764-h1w9gbxk	113	28	imidazole	imidazole	JJ
cord-017764-h1w9gbxk	113	29	N	N	NNP
cord-017764-h1w9gbxk	113	30	-	-	HYPH
cord-017764-h1w9gbxk	113	31	H	H	NNP
cord-017764-h1w9gbxk	113	32	moieties	moiety	NNS
cord-017764-h1w9gbxk	113	33	that	that	WDT
cord-017764-h1w9gbxk	113	34	enhances	enhance	VBZ
cord-017764-h1w9gbxk	113	35	lipophilicity	lipophilicity	NN
cord-017764-h1w9gbxk	113	36	and	and	CC
cord-017764-h1w9gbxk	113	37	reduces	reduce	VBZ
cord-017764-h1w9gbxk	113	38	the	the	DT
cord-017764-h1w9gbxk	113	39	apparent	apparent	JJ
cord-017764-h1w9gbxk	113	40	PSA	PSA	NNP
cord-017764-h1w9gbxk	113	41	of	of	IN
cord-017764-h1w9gbxk	113	42	the	the	DT
cord-017764-h1w9gbxk	113	43	molecule	molecule	NN
cord-017764-h1w9gbxk	113	44	based	base	VBN
cord-017764-h1w9gbxk	113	45	on	on	IN
cord-017764-h1w9gbxk	113	46	a	a	DT
cord-017764-h1w9gbxk	113	47	chromatographic	chromatographic	JJ
cord-017764-h1w9gbxk	113	48	analysis	analysis	NN
cord-017764-h1w9gbxk	113	49	and	and	CC
cord-017764-h1w9gbxk	113	50	which	which	WDT
cord-017764-h1w9gbxk	113	51	is	be	VBZ
cord-017764-h1w9gbxk	113	52	supported	support	VBN
cord-017764-h1w9gbxk	113	53	by	by	IN
cord-017764-h1w9gbxk	113	54	modeling	model	VBG
cord-017764-h1w9gbxk	113	55	studies	study	NNS
cord-017764-h1w9gbxk	113	56	[	[	-LRB-
cord-017764-h1w9gbxk	113	57	41	41	CD
cord-017764-h1w9gbxk	113	58	]	]	-RRB-
cord-017764-h1w9gbxk	113	59	.	.	.
cord-017764-h1w9gbxk	114	1	Despite	despite	IN
cord-017764-h1w9gbxk	114	2	its	-PRON-	PRP$
cord-017764-h1w9gbxk	114	3	high	high	JJ
cord-017764-h1w9gbxk	114	4	potency	potency	NN
cord-017764-h1w9gbxk	114	5	and	and	CC
cord-017764-h1w9gbxk	114	6	broad	broad	JJ
cord-017764-h1w9gbxk	114	7	genotype	genotype	NN
cord-017764-h1w9gbxk	114	8	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	114	9	activity	activity	NN
cord-017764-h1w9gbxk	114	10	,	,	,
cord-017764-h1w9gbxk	114	11	the	the	DT
cord-017764-h1w9gbxk	114	12	precise	precise	JJ
cord-017764-h1w9gbxk	114	13	mode	mode	NN
cord-017764-h1w9gbxk	114	14	of	of	IN
cord-017764-h1w9gbxk	114	15	inhibition	inhibition	NN
cord-017764-h1w9gbxk	114	16	of	of	IN
cord-017764-h1w9gbxk	114	17	HCV	HCV	NNP
cord-017764-h1w9gbxk	114	18	replication	replication	NN
cord-017764-h1w9gbxk	114	19	by	by	IN
cord-017764-h1w9gbxk	114	20	1	1	CD
cord-017764-h1w9gbxk	114	21	remains	remain	NNS
cord-017764-h1w9gbxk	114	22	as	as	RB
cord-017764-h1w9gbxk	114	23	enigmatic	enigmatic	JJ
cord-017764-h1w9gbxk	114	24	as	as	IN
cord-017764-h1w9gbxk	114	25	does	do	VBZ
cord-017764-h1w9gbxk	114	26	the	the	DT
cord-017764-h1w9gbxk	114	27	biochemical	biochemical	JJ
cord-017764-h1w9gbxk	114	28	function	function	NN
cord-017764-h1w9gbxk	114	29	of	of	IN
cord-017764-h1w9gbxk	114	30	the	the	DT
cord-017764-h1w9gbxk	114	31	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	114	32	protein	protein	NN
cord-017764-h1w9gbxk	114	33	[	[	-LRB-
cord-017764-h1w9gbxk	114	34	16	16	CD
cord-017764-h1w9gbxk	114	35	,	,	,
cord-017764-h1w9gbxk	114	36	18	18	CD
cord-017764-h1w9gbxk	114	37	,	,	,
cord-017764-h1w9gbxk	114	38	[	[	-LRB-
cord-017764-h1w9gbxk	114	39	42	42	CD
cord-017764-h1w9gbxk	114	40	]	]	-RRB-
cord-017764-h1w9gbxk	115	1	[	[	-LRB-
cord-017764-h1w9gbxk	115	2	43	43	CD
cord-017764-h1w9gbxk	115	3	]	]	-RRB-
cord-017764-h1w9gbxk	115	4	[	[	-LRB-
cord-017764-h1w9gbxk	115	5	44	44	CD
cord-017764-h1w9gbxk	115	6	]	]	-RRB-
cord-017764-h1w9gbxk	116	1	[	[	-LRB-
cord-017764-h1w9gbxk	116	2	45	45	CD
cord-017764-h1w9gbxk	116	3	]	]	-RRB-
cord-017764-h1w9gbxk	117	1	[	[	-LRB-
cord-017764-h1w9gbxk	117	2	46	46	CD
cord-017764-h1w9gbxk	117	3	]	]	-RRB-
cord-017764-h1w9gbxk	117	4	[	[	-LRB-
cord-017764-h1w9gbxk	117	5	47	47	CD
cord-017764-h1w9gbxk	117	6	]	]	-RRB-
cord-017764-h1w9gbxk	117	7	[	[	-LRB-
cord-017764-h1w9gbxk	117	8	48	48	CD
cord-017764-h1w9gbxk	117	9	]	]	-RRB-
cord-017764-h1w9gbxk	117	10	.	.	.
cord-017764-h1w9gbxk	118	1	HCV	HCV	NNP
cord-017764-h1w9gbxk	118	2	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	118	3	has	have	VBZ
cord-017764-h1w9gbxk	118	4	no	no	DT
cord-017764-h1w9gbxk	118	5	known	know	VBN
cord-017764-h1w9gbxk	118	6	enzymatic	enzymatic	JJ
cord-017764-h1w9gbxk	118	7	activity	activity	NN
cord-017764-h1w9gbxk	118	8	but	but	CC
cord-017764-h1w9gbxk	118	9	is	be	VBZ
cord-017764-h1w9gbxk	118	10	a	a	DT
cord-017764-h1w9gbxk	118	11	critical	critical	JJ
cord-017764-h1w9gbxk	118	12	element	element	NN
cord-017764-h1w9gbxk	118	13	in	in	IN
cord-017764-h1w9gbxk	118	14	the	the	DT
cord-017764-h1w9gbxk	118	15	assembly	assembly	NN
cord-017764-h1w9gbxk	118	16	and	and	CC
cord-017764-h1w9gbxk	118	17	function	function	NN
cord-017764-h1w9gbxk	118	18	of	of	IN
cord-017764-h1w9gbxk	118	19	the	the	DT
cord-017764-h1w9gbxk	118	20	replication	replication	NN
cord-017764-h1w9gbxk	118	21	complex	complex	NN
cord-017764-h1w9gbxk	118	22	on	on	IN
cord-017764-h1w9gbxk	118	23	intracellular	intracellular	JJ
cord-017764-h1w9gbxk	118	24	membranes	membrane	NNS
cord-017764-h1w9gbxk	118	25	and	and	CC
cord-017764-h1w9gbxk	118	26	also	also	RB
cord-017764-h1w9gbxk	118	27	in	in	IN
cord-017764-h1w9gbxk	118	28	virion	virion	NN
cord-017764-h1w9gbxk	118	29	assembly	assembly	NN
cord-017764-h1w9gbxk	118	30	[	[	-LRB-
cord-017764-h1w9gbxk	118	31	16	16	CD
cord-017764-h1w9gbxk	118	32	,	,	,
cord-017764-h1w9gbxk	118	33	[	[	-LRB-
cord-017764-h1w9gbxk	118	34	42	42	CD
cord-017764-h1w9gbxk	118	35	]	]	-RRB-
cord-017764-h1w9gbxk	118	36	[	[	-LRB-
cord-017764-h1w9gbxk	118	37	43	43	CD
cord-017764-h1w9gbxk	118	38	]	]	-RRB-
cord-017764-h1w9gbxk	118	39	[	[	-LRB-
cord-017764-h1w9gbxk	118	40	44	44	CD
cord-017764-h1w9gbxk	118	41	]	]	-RRB-
cord-017764-h1w9gbxk	118	42	[	[	-LRB-
cord-017764-h1w9gbxk	118	43	45	45	CD
cord-017764-h1w9gbxk	118	44	]	]	-RRB-
cord-017764-h1w9gbxk	118	45	[	[	-LRB-
cord-017764-h1w9gbxk	118	46	46	46	CD
cord-017764-h1w9gbxk	118	47	]	]	-RRB-
cord-017764-h1w9gbxk	118	48	[	[	-LRB-
cord-017764-h1w9gbxk	118	49	47	47	CD
cord-017764-h1w9gbxk	118	50	]	]	-RRB-
cord-017764-h1w9gbxk	118	51	[	[	-LRB-
cord-017764-h1w9gbxk	118	52	48	48	CD
cord-017764-h1w9gbxk	118	53	]	]	-RRB-
cord-017764-h1w9gbxk	118	54	.	.	.
cord-017764-h1w9gbxk	119	1	HCV	HCV	NNP
cord-017764-h1w9gbxk	119	2	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	119	3	is	be	VBZ
cord-017764-h1w9gbxk	119	4	a	a	DT
cord-017764-h1w9gbxk	119	5	447-residue	447-residue	CD
cord-017764-h1w9gbxk	119	6	phosphoprotein	phosphoprotein	NN
cord-017764-h1w9gbxk	119	7	that	that	WDT
cord-017764-h1w9gbxk	119	8	is	be	VBZ
cord-017764-h1w9gbxk	119	9	comprised	comprise	VBN
cord-017764-h1w9gbxk	119	10	of	of	IN
cord-017764-h1w9gbxk	119	11	three	three	CD
cord-017764-h1w9gbxk	119	12	functional	functional	JJ
cord-017764-h1w9gbxk	119	13	domains	domain	NNS
cord-017764-h1w9gbxk	119	14	and	and	CC
cord-017764-h1w9gbxk	119	15	an	an	DT
cord-017764-h1w9gbxk	119	16	amphipathic	amphipathic	JJ
cord-017764-h1w9gbxk	119	17	helix	helix	NN
cord-017764-h1w9gbxk	119	18	at	at	IN
cord-017764-h1w9gbxk	119	19	the	the	DT
cord-017764-h1w9gbxk	119	20	amino	amino	NN
cord-017764-h1w9gbxk	119	21	terminus	terminus	NN
cord-017764-h1w9gbxk	119	22	that	that	WDT
cord-017764-h1w9gbxk	119	23	associates	associate	VBZ
cord-017764-h1w9gbxk	119	24	with	with	IN
cord-017764-h1w9gbxk	119	25	but	but	CC
cord-017764-h1w9gbxk	119	26	does	do	VBZ
cord-017764-h1w9gbxk	119	27	not	not	RB
cord-017764-h1w9gbxk	119	28	traverse	traverse	VB
cord-017764-h1w9gbxk	119	29	to	to	IN
cord-017764-h1w9gbxk	119	30	biological	biological	JJ
cord-017764-h1w9gbxk	119	31	membranes	membrane	NNS
cord-017764-h1w9gbxk	119	32	.	.	.
cord-017764-h1w9gbxk	120	1	Domain	domain	NN
cord-017764-h1w9gbxk	120	2	1	1	CD
cord-017764-h1w9gbxk	120	3	contains	contain	VBZ
cord-017764-h1w9gbxk	120	4	a	a	DT
cord-017764-h1w9gbxk	120	5	Zn	Zn	NNP
cord-017764-h1w9gbxk	120	6	2	2	CD
cord-017764-h1w9gbxk	120	7	+	+	SYM
cord-017764-h1w9gbxk	120	8	binding	bind	VBG
cord-017764-h1w9gbxk	120	9	motif	motif	NN
cord-017764-h1w9gbxk	120	10	and	and	CC
cord-017764-h1w9gbxk	120	11	several	several	JJ
cord-017764-h1w9gbxk	120	12	serine	serine	NN
cord-017764-h1w9gbxk	120	13	residues	residue	NNS
cord-017764-h1w9gbxk	120	14	that	that	WDT
cord-017764-h1w9gbxk	120	15	are	be	VBP
cord-017764-h1w9gbxk	120	16	sites	site	NNS
cord-017764-h1w9gbxk	120	17	of	of	IN
cord-017764-h1w9gbxk	120	18	basal	basal	JJ
cord-017764-h1w9gbxk	120	19	phosphorylation	phosphorylation	NN
cord-017764-h1w9gbxk	120	20	and	and	CC
cord-017764-h1w9gbxk	120	21	hyperphosphorylation	hyperphosphorylation	NN
cord-017764-h1w9gbxk	120	22	.	.	.
cord-017764-h1w9gbxk	121	1	The	the	DT
cord-017764-h1w9gbxk	121	2	phosphorylation	phosphorylation	NN
cord-017764-h1w9gbxk	121	3	state	state	NN
cord-017764-h1w9gbxk	121	4	of	of	IN
cord-017764-h1w9gbxk	121	5	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	121	6	may	may	MD
cord-017764-h1w9gbxk	121	7	modulate	modulate	VB
cord-017764-h1w9gbxk	121	8	its	-PRON-	PRP$
cord-017764-h1w9gbxk	121	9	function	function	NN
cord-017764-h1w9gbxk	121	10	in	in	IN
cord-017764-h1w9gbxk	121	11	virus	virus	NN
cord-017764-h1w9gbxk	121	12	replication	replication	NN
cord-017764-h1w9gbxk	121	13	and	and	CC
cord-017764-h1w9gbxk	121	14	assembly	assembly	NN
cord-017764-h1w9gbxk	121	15	with	with	IN
cord-017764-h1w9gbxk	121	16	the	the	DT
cord-017764-h1w9gbxk	121	17	hyperphosphorylated	hyperphosphorylate	VBN
cord-017764-h1w9gbxk	121	18	form	form	NN
cord-017764-h1w9gbxk	121	19	,	,	,
cord-017764-h1w9gbxk	121	20	which	which	WDT
cord-017764-h1w9gbxk	121	21	can	can	MD
cord-017764-h1w9gbxk	121	22	be	be	VB
cord-017764-h1w9gbxk	121	23	produced	produce	VBN
cord-017764-h1w9gbxk	121	24	by	by	IN
cord-017764-h1w9gbxk	121	25	the	the	DT
cord-017764-h1w9gbxk	121	26	action	action	NN
cord-017764-h1w9gbxk	121	27	of	of	IN
cord-017764-h1w9gbxk	121	28	the	the	DT
cord-017764-h1w9gbxk	121	29	host	host	NN
cord-017764-h1w9gbxk	121	30	cell	cell	NN
cord-017764-h1w9gbxk	121	31	lipid	lipid	NN
cord-017764-h1w9gbxk	121	32	kinase	kinase	NN
cord-017764-h1w9gbxk	121	33	,	,	,
cord-017764-h1w9gbxk	121	34	phosphatidylinositol	phosphatidylinositol	JJ
cord-017764-h1w9gbxk	121	35	4-kinase	4-kinase	CD
cord-017764-h1w9gbxk	121	36	,	,	,
cord-017764-h1w9gbxk	121	37	involved	involve	VBN
cord-017764-h1w9gbxk	121	38	in	in	IN
cord-017764-h1w9gbxk	121	39	the	the	DT
cord-017764-h1w9gbxk	121	40	assembly	assembly	NN
cord-017764-h1w9gbxk	121	41	of	of	IN
cord-017764-h1w9gbxk	121	42	virions	virion	NNS
cord-017764-h1w9gbxk	121	43	.	.	.
cord-017764-h1w9gbxk	122	1	Domain	domain	NN
cord-017764-h1w9gbxk	122	2	2	2	CD
cord-017764-h1w9gbxk	122	3	has	have	VBZ
cord-017764-h1w9gbxk	122	4	been	be	VBN
cord-017764-h1w9gbxk	122	5	shown	show	VBN
cord-017764-h1w9gbxk	122	6	to	to	TO
cord-017764-h1w9gbxk	122	7	bind	bind	VB
cord-017764-h1w9gbxk	122	8	to	to	IN
cord-017764-h1w9gbxk	122	9	the	the	DT
cord-017764-h1w9gbxk	122	10	NS5B	NS5B	NNP
cord-017764-h1w9gbxk	122	11	RNA	RNA	NNP
cord-017764-h1w9gbxk	122	12	-	-	HYPH
cord-017764-h1w9gbxk	122	13	dependent	dependent	JJ
cord-017764-h1w9gbxk	122	14	RNA	RNA	NNP
cord-017764-h1w9gbxk	122	15	polymerase	polymerase	NN
cord-017764-h1w9gbxk	122	16	and	and	CC
cord-017764-h1w9gbxk	122	17	has	have	VBZ
cord-017764-h1w9gbxk	122	18	been	be	VBN
cord-017764-h1w9gbxk	122	19	associated	associate	VBN
cord-017764-h1w9gbxk	122	20	with	with	IN
cord-017764-h1w9gbxk	122	21	the	the	DT
cord-017764-h1w9gbxk	122	22	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	122	23	of	of	IN
cord-017764-h1w9gbxk	122	24	the	the	DT
cord-017764-h1w9gbxk	122	25	virus	virus	NN
cord-017764-h1w9gbxk	122	26	to	to	IN
cord-017764-h1w9gbxk	122	27	interferon	interferon	NN
cord-017764-h1w9gbxk	122	28	therapy	therapy	NN
cord-017764-h1w9gbxk	122	29	although	although	IN
cord-017764-h1w9gbxk	122	30	that	that	DT
cord-017764-h1w9gbxk	122	31	function	function	NN
cord-017764-h1w9gbxk	122	32	is	be	VBZ
cord-017764-h1w9gbxk	122	33	controversial	controversial	JJ
cord-017764-h1w9gbxk	122	34	.	.	.
cord-017764-h1w9gbxk	123	1	While	while	IN
cord-017764-h1w9gbxk	123	2	domain	domain	NN
cord-017764-h1w9gbxk	123	3	latter	latter	JJ
cord-017764-h1w9gbxk	123	4	effect	effect	NN
cord-017764-h1w9gbxk	123	5	has	have	VBZ
cord-017764-h1w9gbxk	123	6	been	be	VBN
cord-017764-h1w9gbxk	123	7	postulated	postulate	VBN
cord-017764-h1w9gbxk	123	8	to	to	TO
cord-017764-h1w9gbxk	123	9	explain	explain	VB
cord-017764-h1w9gbxk	123	10	the	the	DT
cord-017764-h1w9gbxk	123	11	rapid	rapid	JJ
cord-017764-h1w9gbxk	123	12	decline	decline	NN
cord-017764-h1w9gbxk	123	13	in	in	IN
cord-017764-h1w9gbxk	123	14	viremia	viremia	NN
cord-017764-h1w9gbxk	123	15	observed	observe	VBN
cord-017764-h1w9gbxk	123	16	in	in	IN
cord-017764-h1w9gbxk	123	17	HCV	HCV	NNP
cord-017764-h1w9gbxk	123	18	-	-	HYPH
cord-017764-h1w9gbxk	123	19	infected	infect	VBN
cord-017764-h1w9gbxk	123	20	patients	patient	NNS
cord-017764-h1w9gbxk	123	21	administered	administer	VBN
cord-017764-h1w9gbxk	123	22	clinically	clinically	RB
cord-017764-h1w9gbxk	123	23	effective	effective	JJ
cord-017764-h1w9gbxk	123	24	doses	dose	NNS
cord-017764-h1w9gbxk	123	25	of	of	IN
cord-017764-h1w9gbxk	123	26	1	1	CD
cord-017764-h1w9gbxk	123	27	(	(	-LRB-
cord-017764-h1w9gbxk	123	28	vide	vide	NN
cord-017764-h1w9gbxk	123	29	infra	infra	NN
cord-017764-h1w9gbxk	123	30	)	)	-RRB-
cord-017764-h1w9gbxk	123	31	[	[	-LRB-
cord-017764-h1w9gbxk	123	32	3	3	CD
cord-017764-h1w9gbxk	123	33	,	,	,
cord-017764-h1w9gbxk	123	34	51	51	CD
cord-017764-h1w9gbxk	123	35	]	]	-RRB-
cord-017764-h1w9gbxk	123	36	.	.	.
cord-017764-h1w9gbxk	124	1	In	in	IN
cord-017764-h1w9gbxk	124	2	addition	addition	NN
cord-017764-h1w9gbxk	124	3	to	to	IN
cord-017764-h1w9gbxk	124	4	associating	associate	VBG
cord-017764-h1w9gbxk	124	5	with	with	IN
cord-017764-h1w9gbxk	124	6	all	all	DT
cord-017764-h1w9gbxk	124	7	of	of	IN
cord-017764-h1w9gbxk	124	8	the	the	DT
cord-017764-h1w9gbxk	124	9	viral	viral	JJ
cord-017764-h1w9gbxk	124	10	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	124	11	proteins	protein	NNS
cord-017764-h1w9gbxk	124	12	,	,	,
cord-017764-h1w9gbxk	124	13	HCV	HCV	NNP
cord-017764-h1w9gbxk	124	14	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	124	15	has	have	VBZ
cord-017764-h1w9gbxk	124	16	also	also	RB
cord-017764-h1w9gbxk	124	17	been	be	VBN
cord-017764-h1w9gbxk	124	18	shown	show	VBN
cord-017764-h1w9gbxk	124	19	to	to	TO
cord-017764-h1w9gbxk	124	20	bind	bind	VB
cord-017764-h1w9gbxk	124	21	to	to	IN
cord-017764-h1w9gbxk	124	22	an	an	DT
cord-017764-h1w9gbxk	124	23	extensive	extensive	JJ
cord-017764-h1w9gbxk	124	24	repertoire	repertoire	NN
cord-017764-h1w9gbxk	124	25	of	of	IN
cord-017764-h1w9gbxk	124	26	host	host	NN
cord-017764-h1w9gbxk	124	27	cell	cell	NN
cord-017764-h1w9gbxk	124	28	proteins	protein	NNS
cord-017764-h1w9gbxk	124	29	that	that	WDT
cord-017764-h1w9gbxk	124	30	exceeds	exceed	VBZ
cord-017764-h1w9gbxk	124	31	130	130	CD
cord-017764-h1w9gbxk	124	32	entities	entity	NNS
cord-017764-h1w9gbxk	124	33	[	[	-LRB-
cord-017764-h1w9gbxk	124	34	52	52	CD
cord-017764-h1w9gbxk	124	35	]	]	-RRB-
cord-017764-h1w9gbxk	124	36	[	[	-LRB-
cord-017764-h1w9gbxk	124	37	53	53	CD
cord-017764-h1w9gbxk	124	38	]	]	-RRB-
cord-017764-h1w9gbxk	124	39	[	[	-LRB-
cord-017764-h1w9gbxk	124	40	54	54	CD
cord-017764-h1w9gbxk	124	41	]	]	-RRB-
cord-017764-h1w9gbxk	125	1	[	[	-LRB-
cord-017764-h1w9gbxk	125	2	55	55	CD
cord-017764-h1w9gbxk	125	3	]	]	-RRB-
cord-017764-h1w9gbxk	125	4	[	[	-LRB-
cord-017764-h1w9gbxk	125	5	56	56	CD
cord-017764-h1w9gbxk	125	6	]	]	-RRB-
cord-017764-h1w9gbxk	125	7	[	[	-LRB-
cord-017764-h1w9gbxk	125	8	57	57	CD
cord-017764-h1w9gbxk	125	9	]	]	-RRB-
cord-017764-h1w9gbxk	125	10	.	.	.
cord-017764-h1w9gbxk	126	1	As	as	IN
cord-017764-h1w9gbxk	126	2	a	a	DT
cord-017764-h1w9gbxk	126	3	consequence	consequence	NN
cord-017764-h1w9gbxk	126	4	,	,	,
cord-017764-h1w9gbxk	126	5	the	the	DT
cord-017764-h1w9gbxk	126	6	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	126	7	protein	protein	NN
cord-017764-h1w9gbxk	126	8	is	be	VBZ
cord-017764-h1w9gbxk	126	9	typically	typically	RB
cord-017764-h1w9gbxk	126	10	viewed	view	VBN
cord-017764-h1w9gbxk	126	11	as	as	IN
cord-017764-h1w9gbxk	126	12	a	a	DT
cord-017764-h1w9gbxk	126	13	master	master	NN
cord-017764-h1w9gbxk	126	14	regulator	regulator	NN
cord-017764-h1w9gbxk	126	15	of	of	IN
cord-017764-h1w9gbxk	126	16	virus	virus	NN
cord-017764-h1w9gbxk	126	17	replication	replication	NN
cord-017764-h1w9gbxk	126	18	and	and	CC
cord-017764-h1w9gbxk	126	19	virion	virion	NN
cord-017764-h1w9gbxk	126	20	production	production	NN
cord-017764-h1w9gbxk	126	21	,	,	,
cord-017764-h1w9gbxk	126	22	orchestrating	orchestrate	VBG
cord-017764-h1w9gbxk	126	23	both	both	DT
cord-017764-h1w9gbxk	126	24	viral	viral	JJ
cord-017764-h1w9gbxk	126	25	proteins	protein	NNS
cord-017764-h1w9gbxk	126	26	and	and	CC
cord-017764-h1w9gbxk	126	27	the	the	DT
cord-017764-h1w9gbxk	126	28	host	host	NN
cord-017764-h1w9gbxk	126	29	cell	cell	NN
cord-017764-h1w9gbxk	126	30	environment	environment	NN
cord-017764-h1w9gbxk	126	31	to	to	TO
cord-017764-h1w9gbxk	126	32	ensure	ensure	VB
cord-017764-h1w9gbxk	126	33	the	the	DT
cord-017764-h1w9gbxk	126	34	successful	successful	JJ
cord-017764-h1w9gbxk	126	35	production	production	NN
cord-017764-h1w9gbxk	126	36	and	and	CC
cord-017764-h1w9gbxk	126	37	release	release	NN
cord-017764-h1w9gbxk	126	38	of	of	IN
cord-017764-h1w9gbxk	126	39	progeny	progeny	JJ
cord-017764-h1w9gbxk	126	40	virus	virus	NN
cord-017764-h1w9gbxk	126	41	[	[	-LRB-
cord-017764-h1w9gbxk	126	42	42	42	CD
cord-017764-h1w9gbxk	126	43	]	]	-RRB-
cord-017764-h1w9gbxk	126	44	[	[	-LRB-
cord-017764-h1w9gbxk	126	45	43	43	CD
cord-017764-h1w9gbxk	126	46	]	]	-RRB-
cord-017764-h1w9gbxk	126	47	[	[	-LRB-
cord-017764-h1w9gbxk	126	48	44	44	CD
cord-017764-h1w9gbxk	126	49	]	]	-RRB-
cord-017764-h1w9gbxk	126	50	[	[	-LRB-
cord-017764-h1w9gbxk	126	51	45	45	CD
cord-017764-h1w9gbxk	126	52	]	]	-RRB-
cord-017764-h1w9gbxk	127	1	[	[	-LRB-
cord-017764-h1w9gbxk	127	2	46	46	CD
cord-017764-h1w9gbxk	127	3	]	]	-RRB-
cord-017764-h1w9gbxk	127	4	[	[	-LRB-
cord-017764-h1w9gbxk	127	5	47	47	CD
cord-017764-h1w9gbxk	127	6	]	]	-RRB-
cord-017764-h1w9gbxk	127	7	[	[	-LRB-
cord-017764-h1w9gbxk	127	8	48	48	CD
cord-017764-h1w9gbxk	127	9	]	]	-RRB-
cord-017764-h1w9gbxk	127	10	.	.	.
cord-017764-h1w9gbxk	128	1	An	an	DT
cord-017764-h1w9gbxk	128	2	association	association	NN
cord-017764-h1w9gbxk	128	3	of	of	IN
cord-017764-h1w9gbxk	128	4	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	128	5	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	128	6	with	with	IN
cord-017764-h1w9gbxk	128	7	the	the	DT
cord-017764-h1w9gbxk	128	8	viral	viral	JJ
cord-017764-h1w9gbxk	128	9	protein	protein	NN
cord-017764-h1w9gbxk	128	10	was	be	VBD
cord-017764-h1w9gbxk	128	11	originally	originally	RB
cord-017764-h1w9gbxk	128	12	demonstrated	demonstrate	VBN
cord-017764-h1w9gbxk	128	13	by	by	IN
cord-017764-h1w9gbxk	128	14	studies	study	NNS
cord-017764-h1w9gbxk	128	15	with	with	IN
cord-017764-h1w9gbxk	128	16	the	the	DT
cord-017764-h1w9gbxk	128	17	biotin	biotin	NN
cord-017764-h1w9gbxk	128	18	-	-	HYPH
cord-017764-h1w9gbxk	128	19	labeled	label	VBN
cord-017764-h1w9gbxk	128	20	derivative	derivative	JJ
cord-017764-h1w9gbxk	128	21	50	50	CD
cord-017764-h1w9gbxk	128	22	which	which	WDT
cord-017764-h1w9gbxk	128	23	is	be	VBZ
cord-017764-h1w9gbxk	128	24	an	an	DT
cord-017764-h1w9gbxk	128	25	effective	effective	JJ
cord-017764-h1w9gbxk	128	26	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	128	27	of	of	IN
cord-017764-h1w9gbxk	128	28	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	128	29	replication	replication	NN
cord-017764-h1w9gbxk	128	30	[	[	-LRB-
cord-017764-h1w9gbxk	128	31	3	3	CD
cord-017764-h1w9gbxk	128	32	]	]	-RRB-
cord-017764-h1w9gbxk	128	33	.	.	.
cord-017764-h1w9gbxk	129	1	The	the	DT
cord-017764-h1w9gbxk	129	2	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	129	3	activity	activity	NN
cord-017764-h1w9gbxk	129	4	of	of	IN
cord-017764-h1w9gbxk	129	5	50	50	CD
cord-017764-h1w9gbxk	129	6	is	be	VBZ
cord-017764-h1w9gbxk	129	7	highly	highly	RB
cord-017764-h1w9gbxk	129	8	sensitive	sensitive	JJ
cord-017764-h1w9gbxk	129	9	to	to	IN
cord-017764-h1w9gbxk	129	10	the	the	DT
cord-017764-h1w9gbxk	129	11	absolute	absolute	JJ
cord-017764-h1w9gbxk	129	12	configuration	configuration	NN
cord-017764-h1w9gbxk	129	13	of	of	IN
cord-017764-h1w9gbxk	129	14	the	the	DT
cord-017764-h1w9gbxk	129	15	proline	proline	NN
cord-017764-h1w9gbxk	129	16	moiety	moiety	NN
cord-017764-h1w9gbxk	129	17	since	since	IN
cord-017764-h1w9gbxk	129	18	the	the	DT
cord-017764-h1w9gbxk	129	19	(	(	-LRB-
cord-017764-h1w9gbxk	129	20	R	r	NN
cord-017764-h1w9gbxk	129	21	,	,	,
cord-017764-h1w9gbxk	129	22	R)-isomer	R)-isomer	NNP
cord-017764-h1w9gbxk	129	23	51	51	CD
cord-017764-h1w9gbxk	129	24	is	be	VBZ
cord-017764-h1w9gbxk	129	25	inactive	inactive	JJ
cord-017764-h1w9gbxk	129	26	,	,	,
cord-017764-h1w9gbxk	129	27	while	while	IN
cord-017764-h1w9gbxk	129	28	inhibition	inhibition	NN
cord-017764-h1w9gbxk	129	29	is	be	VBZ
cord-017764-h1w9gbxk	129	30	substantially	substantially	RB
cord-017764-h1w9gbxk	129	31	reduced	reduce	VBN
cord-017764-h1w9gbxk	129	32	by	by	IN
cord-017764-h1w9gbxk	129	33	the	the	DT
cord-017764-h1w9gbxk	129	34	Tyr93His	Tyr93His	NNP
cord-017764-h1w9gbxk	129	35	resistance	resistance	NN
cord-017764-h1w9gbxk	129	36	mutation	mutation	NN
cord-017764-h1w9gbxk	129	37	that	that	WDT
cord-017764-h1w9gbxk	129	38	arises	arise	VBZ
cord-017764-h1w9gbxk	129	39	in	in	IN
cord-017764-h1w9gbxk	129	40	response	response	NN
cord-017764-h1w9gbxk	129	41	to	to	IN
cord-017764-h1w9gbxk	129	42	virus	virus	NN
cord-017764-h1w9gbxk	129	43	passaging	passage	VBG
cord-017764-h1w9gbxk	129	44	in	in	IN
cord-017764-h1w9gbxk	129	45	the	the	DT
cord-017764-h1w9gbxk	129	46	presence	presence	NN
cord-017764-h1w9gbxk	129	47	of	of	IN
cord-017764-h1w9gbxk	129	48	1	1	CD
cord-017764-h1w9gbxk	129	49	.	.	.
cord-017764-h1w9gbxk	130	1	This	this	DT
cord-017764-h1w9gbxk	130	2	SAR	SAR	NNP
cord-017764-h1w9gbxk	130	3	profile	profile	NN
cord-017764-h1w9gbxk	130	4	is	be	VBZ
cord-017764-h1w9gbxk	130	5	strictly	strictly	RB
cord-017764-h1w9gbxk	130	6	analogous	analogous	JJ
cord-017764-h1w9gbxk	130	7	to	to	IN
cord-017764-h1w9gbxk	130	8	that	that	DT
cord-017764-h1w9gbxk	130	9	established	establish	VBN
cord-017764-h1w9gbxk	130	10	for	for	IN
cord-017764-h1w9gbxk	130	11	the	the	DT
cord-017764-h1w9gbxk	130	12	stilbene	stilbene	NNP
cord-017764-h1w9gbxk	130	13	chemotype	chemotype	NNP
cord-017764-h1w9gbxk	130	14	,	,	,
cord-017764-h1w9gbxk	130	15	and	and	CC
cord-017764-h1w9gbxk	130	16	50	50	CD
cord-017764-h1w9gbxk	130	17	was	be	VBD
cord-017764-h1w9gbxk	130	18	thus	thus	RB
cord-017764-h1w9gbxk	130	19	viewed	view	VBN
cord-017764-h1w9gbxk	130	20	as	as	IN
cord-017764-h1w9gbxk	130	21	a	a	DT
cord-017764-h1w9gbxk	130	22	useful	useful	JJ
cord-017764-h1w9gbxk	130	23	tool	tool	NN
cord-017764-h1w9gbxk	130	24	molecule	molecule	NN
cord-017764-h1w9gbxk	130	25	with	with	IN
cord-017764-h1w9gbxk	130	26	which	which	WDT
cord-017764-h1w9gbxk	130	27	to	to	TO
cord-017764-h1w9gbxk	130	28	probe	probe	VB
cord-017764-h1w9gbxk	130	29	drug	drug	NN
cord-017764-h1w9gbxk	130	30	-	-	HYPH
cord-017764-h1w9gbxk	130	31	target	target	NN
cord-017764-h1w9gbxk	130	32	binding	bind	VBG
cord-017764-h1w9gbxk	130	33	interactions	interaction	NNS
cord-017764-h1w9gbxk	130	34	.	.	.
cord-017764-h1w9gbxk	131	1	In	in	IN
cord-017764-h1w9gbxk	131	2	an	an	DT
cord-017764-h1w9gbxk	131	3	initial	initial	JJ
cord-017764-h1w9gbxk	131	4	experiment	experiment	NN
cord-017764-h1w9gbxk	131	5	,	,	,
cord-017764-h1w9gbxk	131	6	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	131	7	replicon	replicon	NN
cord-017764-h1w9gbxk	131	8	lysate	lysate	NN
cord-017764-h1w9gbxk	131	9	was	be	VBD
cord-017764-h1w9gbxk	131	10	incubated	incubate	VBN
cord-017764-h1w9gbxk	131	11	with	with	IN
cord-017764-h1w9gbxk	131	12	50	50	CD
cord-017764-h1w9gbxk	131	13	,	,	,
cord-017764-h1w9gbxk	131	14	and	and	CC
cord-017764-h1w9gbxk	131	15	the	the	DT
cord-017764-h1w9gbxk	131	16	mixture	mixture	NN
cord-017764-h1w9gbxk	131	17	passed	pass	VBN
cord-017764-h1w9gbxk	131	18	over	over	RP
cord-017764-h1w9gbxk	131	19	streptavidin	streptavidin	NNS
cord-017764-h1w9gbxk	131	20	immobilized	immobilize	VBN
cord-017764-h1w9gbxk	131	21	on	on	IN
cord-017764-h1w9gbxk	131	22	beads	bead	NNS
cord-017764-h1w9gbxk	131	23	;	;	:
cord-017764-h1w9gbxk	131	24	however	however	RB
cord-017764-h1w9gbxk	131	25	,	,	,
cord-017764-h1w9gbxk	131	26	this	this	DT
cord-017764-h1w9gbxk	131	27	experimental	experimental	JJ
cord-017764-h1w9gbxk	131	28	protocol	protocol	NN
cord-017764-h1w9gbxk	131	29	failed	fail	VBD
cord-017764-h1w9gbxk	131	30	to	to	TO
cord-017764-h1w9gbxk	131	31	pull	pull	VB
cord-017764-h1w9gbxk	131	32	down	down	RP
cord-017764-h1w9gbxk	131	33	any	any	DT
cord-017764-h1w9gbxk	131	34	viral	viral	JJ
cord-017764-h1w9gbxk	131	35	protein	protein	NN
cord-017764-h1w9gbxk	131	36	.	.	.
cord-017764-h1w9gbxk	132	1	In	in	IN
cord-017764-h1w9gbxk	132	2	contrast	contrast	NN
cord-017764-h1w9gbxk	132	3	,	,	,
cord-017764-h1w9gbxk	132	4	incubating	incubate	VBG
cord-017764-h1w9gbxk	132	5	replicon	replicon	NN
cord-017764-h1w9gbxk	132	6	cells	cell	NNS
cord-017764-h1w9gbxk	132	7	with	with	IN
cord-017764-h1w9gbxk	132	8	50	50	CD
cord-017764-h1w9gbxk	132	9	for	for	IN
cord-017764-h1w9gbxk	132	10	18	18	CD
cord-017764-h1w9gbxk	132	11	h	h	NN
cord-017764-h1w9gbxk	132	12	before	before	IN
cord-017764-h1w9gbxk	132	13	lysing	lyse	VBG
cord-017764-h1w9gbxk	132	14	and	and	CC
cord-017764-h1w9gbxk	132	15	passing	pass	VBG
cord-017764-h1w9gbxk	132	16	the	the	DT
cord-017764-h1w9gbxk	132	17	lysate	lysate	NN
cord-017764-h1w9gbxk	132	18	over	over	IN
cord-017764-h1w9gbxk	132	19	streptavidin	streptavidin	NNP
cord-017764-h1w9gbxk	132	20	beads	bead	NNS
cord-017764-h1w9gbxk	132	21	identified	identify	VBN
cord-017764-h1w9gbxk	132	22	only	only	RB
cord-017764-h1w9gbxk	132	23	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	132	24	as	as	IN
cord-017764-h1w9gbxk	132	25	a	a	DT
cord-017764-h1w9gbxk	132	26	binding	bind	VBG
cord-017764-h1w9gbxk	132	27	partner	partner	NN
cord-017764-h1w9gbxk	132	28	,	,	,
cord-017764-h1w9gbxk	132	29	while	while	IN
cord-017764-h1w9gbxk	132	30	a	a	DT
cord-017764-h1w9gbxk	132	31	control	control	NN
cord-017764-h1w9gbxk	132	32	experiment	experiment	NN
cord-017764-h1w9gbxk	132	33	with	with	IN
cord-017764-h1w9gbxk	132	34	inactive	inactive	JJ
cord-017764-h1w9gbxk	132	35	diastereomer	diastereomer	NNP
cord-017764-h1w9gbxk	132	36	50	50	CD
cord-017764-h1w9gbxk	132	37	failed	fail	VBD
cord-017764-h1w9gbxk	132	38	to	to	TO
cord-017764-h1w9gbxk	132	39	isolate	isolate	VB
cord-017764-h1w9gbxk	132	40	any	any	DT
cord-017764-h1w9gbxk	132	41	virial	virial	JJ
cord-017764-h1w9gbxk	132	42	proteins	protein	NNS
cord-017764-h1w9gbxk	132	43	.	.	.
cord-017764-h1w9gbxk	133	1	These	these	DT
cord-017764-h1w9gbxk	133	2	results	result	NNS
cord-017764-h1w9gbxk	133	3	indicate	indicate	VBP
cord-017764-h1w9gbxk	133	4	that	that	IN
cord-017764-h1w9gbxk	133	5	50	50	CD
cord-017764-h1w9gbxk	133	6	binds	bind	NNS
cord-017764-h1w9gbxk	133	7	to	to	IN
cord-017764-h1w9gbxk	133	8	HCV	HCV	NNP
cord-017764-h1w9gbxk	133	9	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	133	10	and	and	CC
cord-017764-h1w9gbxk	133	11	that	that	IN
cord-017764-h1w9gbxk	133	12	binding	binding	NN
cord-017764-h1w9gbxk	133	13	is	be	VBZ
cord-017764-h1w9gbxk	133	14	dependent	dependent	JJ
cord-017764-h1w9gbxk	133	15	on	on	IN
cord-017764-h1w9gbxk	133	16	the	the	DT
cord-017764-h1w9gbxk	133	17	absolute	absolute	JJ
cord-017764-h1w9gbxk	133	18	configuration	configuration	NN
cord-017764-h1w9gbxk	133	19	of	of	IN
cord-017764-h1w9gbxk	133	20	the	the	DT
cord-017764-h1w9gbxk	133	21	proline	proline	NN
cord-017764-h1w9gbxk	133	22	element	element	NN
cord-017764-h1w9gbxk	133	23	,	,	,
cord-017764-h1w9gbxk	133	24	an	an	DT
cord-017764-h1w9gbxk	133	25	observation	observation	NN
cord-017764-h1w9gbxk	133	26	concordant	concordant	JJ
cord-017764-h1w9gbxk	133	27	with	with	IN
cord-017764-h1w9gbxk	133	28	the	the	DT
cord-017764-h1w9gbxk	133	29	SARs	SARs	NNP
cord-017764-h1w9gbxk	133	30	developed	develop	VBN
cord-017764-h1w9gbxk	133	31	in	in	IN
cord-017764-h1w9gbxk	133	32	the	the	DT
cord-017764-h1w9gbxk	133	33	stilbene	stilbene	NN
cord-017764-h1w9gbxk	133	34	-	-	HYPH
cord-017764-h1w9gbxk	133	35	based	base	VBN
cord-017764-h1w9gbxk	133	36	series	series	NN
cord-017764-h1w9gbxk	133	37	.	.	.
cord-017764-h1w9gbxk	134	1	While	while	IN
cord-017764-h1w9gbxk	134	2	the	the	DT
cord-017764-h1w9gbxk	134	3	experiments	experiment	NNS
cord-017764-h1w9gbxk	134	4	conducted	conduct	VBN
cord-017764-h1w9gbxk	134	5	with	with	IN
cord-017764-h1w9gbxk	134	6	50	50	CD
cord-017764-h1w9gbxk	134	7	indicate	indicate	VBP
cord-017764-h1w9gbxk	134	8	that	that	IN
cord-017764-h1w9gbxk	134	9	the	the	DT
cord-017764-h1w9gbxk	134	10	binding	binding	NN
cord-017764-h1w9gbxk	134	11	of	of	IN
cord-017764-h1w9gbxk	134	12	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	134	13	to	to	IN
cord-017764-h1w9gbxk	134	14	the	the	DT
cord-017764-h1w9gbxk	134	15	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	134	16	is	be	VBZ
cord-017764-h1w9gbxk	134	17	choreographically	choreographically	RB
cord-017764-h1w9gbxk	134	18	somewhat	somewhat	RB
cord-017764-h1w9gbxk	134	19	complex	complex	JJ
cord-017764-h1w9gbxk	134	20	,	,	,
cord-017764-h1w9gbxk	134	21	the	the	DT
cord-017764-h1w9gbxk	134	22	binding	binding	NN
cord-017764-h1w9gbxk	134	23	of	of	IN
cord-017764-h1w9gbxk	134	24	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	134	25	of	of	IN
cord-017764-h1w9gbxk	134	26	NS5A	NS5A	NNS
cord-017764-h1w9gbxk	134	27	to	to	IN
cord-017764-h1w9gbxk	134	28	both	both	DT
cord-017764-h1w9gbxk	134	29	domain	domain	NN
cord-017764-h1w9gbxk	134	30	1	1	CD
cord-017764-h1w9gbxk	134	31	and	and	CC
cord-017764-h1w9gbxk	134	32	the	the	DT
cord-017764-h1w9gbxk	134	33	full	full	JJ
cord-017764-h1w9gbxk	134	34	-	-	HYPH
cord-017764-h1w9gbxk	134	35	length	length	NN
cord-017764-h1w9gbxk	134	36	viral	viral	JJ
cord-017764-h1w9gbxk	134	37	protein	protein	NN
cord-017764-h1w9gbxk	134	38	was	be	VBD
cord-017764-h1w9gbxk	134	39	subsequently	subsequently	RB
cord-017764-h1w9gbxk	134	40	demonstrated	demonstrate	VBN
cord-017764-h1w9gbxk	134	41	in	in	IN
cord-017764-h1w9gbxk	134	42	a	a	DT
cord-017764-h1w9gbxk	134	43	series	series	NN
cord-017764-h1w9gbxk	134	44	of	of	IN
cord-017764-h1w9gbxk	134	45	independent	independent	JJ
cord-017764-h1w9gbxk	134	46	biochemical	biochemical	JJ
cord-017764-h1w9gbxk	134	47	experiments	experiment	NNS
cord-017764-h1w9gbxk	134	48	[	[	-LRB-
cord-017764-h1w9gbxk	134	49	58	58	CD
cord-017764-h1w9gbxk	134	50	,	,	,
cord-017764-h1w9gbxk	134	51	59	59	CD
cord-017764-h1w9gbxk	134	52	]	]	-RRB-
cord-017764-h1w9gbxk	134	53	.	.	.
cord-017764-h1w9gbxk	135	1	These	these	DT
cord-017764-h1w9gbxk	135	2	studies	study	NNS
cord-017764-h1w9gbxk	135	3	have	have	VBP
cord-017764-h1w9gbxk	135	4	suggested	suggest	VBN
cord-017764-h1w9gbxk	135	5	that	that	IN
cord-017764-h1w9gbxk	135	6	the	the	DT
cord-017764-h1w9gbxk	135	7	binding	binding	NN
cord-017764-h1w9gbxk	135	8	of	of	IN
cord-017764-h1w9gbxk	135	9	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	135	10	to	to	IN
cord-017764-h1w9gbxk	135	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	135	12	interferes	interfere	VBZ
cord-017764-h1w9gbxk	135	13	with	with	IN
cord-017764-h1w9gbxk	135	14	the	the	DT
cord-017764-h1w9gbxk	135	15	association	association	NNP
cord-017764-h1w9gbxk	135	16	of	of	IN
cord-017764-h1w9gbxk	135	17	viral	viral	NNP
cord-017764-h1w9gbxk	135	18	RNA	RNA	NNP
cord-017764-h1w9gbxk	135	19	with	with	IN
cord-017764-h1w9gbxk	135	20	the	the	DT
cord-017764-h1w9gbxk	135	21	protein	protein	NN
cord-017764-h1w9gbxk	135	22	,	,	,
cord-017764-h1w9gbxk	135	23	with	with	IN
cord-017764-h1w9gbxk	135	24	the	the	DT
cord-017764-h1w9gbxk	135	25	binding	binding	NN
cord-017764-h1w9gbxk	135	26	of	of	IN
cord-017764-h1w9gbxk	135	27	compounds	compound	NNS
cord-017764-h1w9gbxk	135	28	competed	compete	VBD
cord-017764-h1w9gbxk	135	29	out	out	RP
cord-017764-h1w9gbxk	135	30	by	by	IN
cord-017764-h1w9gbxk	135	31	other	other	JJ
cord-017764-h1w9gbxk	135	32	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	135	33	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	135	34	and	and	CC
cord-017764-h1w9gbxk	135	35	demonstrating	demonstrate	VBG
cord-017764-h1w9gbxk	135	36	diminished	diminish	VBN
cord-017764-h1w9gbxk	135	37	affinity	affinity	NN
cord-017764-h1w9gbxk	135	38	for	for	IN
cord-017764-h1w9gbxk	135	39	the	the	DT
cord-017764-h1w9gbxk	135	40	Tyr93His	Tyr93His	NNP
cord-017764-h1w9gbxk	135	41	mutant	mutant	JJ
cord-017764-h1w9gbxk	135	42	protein	protein	NN
cord-017764-h1w9gbxk	135	43	[	[	-LRB-
cord-017764-h1w9gbxk	135	44	58	58	CD
cord-017764-h1w9gbxk	135	45	,	,	,
cord-017764-h1w9gbxk	135	46	59	59	CD
cord-017764-h1w9gbxk	135	47	]	]	-RRB-
cord-017764-h1w9gbxk	135	48	.	.	.
cord-017764-h1w9gbxk	136	1	However	however	RB
cord-017764-h1w9gbxk	136	2	,	,	,
cord-017764-h1w9gbxk	136	3	profiling	profiling	NN
cord-017764-h1w9gbxk	136	4	of	of	IN
cord-017764-h1w9gbxk	136	5	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	136	6	in	in	IN
cord-017764-h1w9gbxk	136	7	cell	cell	NN
cord-017764-h1w9gbxk	136	8	-	-	HYPH
cord-017764-h1w9gbxk	136	9	based	base	VBN
cord-017764-h1w9gbxk	136	10	assays	assay	NNS
cord-017764-h1w9gbxk	136	11	has	have	VBZ
cord-017764-h1w9gbxk	136	12	indicated	indicate	VBN
cord-017764-h1w9gbxk	136	13	that	that	IN
cord-017764-h1w9gbxk	136	14	disruption	disruption	NN
cord-017764-h1w9gbxk	136	15	of	of	IN
cord-017764-h1w9gbxk	136	16	RNA	rna	NN
cord-017764-h1w9gbxk	136	17	binding	bind	VBG
cord-017764-h1w9gbxk	136	18	to	to	IN
cord-017764-h1w9gbxk	136	19	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	136	20	does	do	VBZ
cord-017764-h1w9gbxk	136	21	not	not	RB
cord-017764-h1w9gbxk	136	22	appear	appear	VB
cord-017764-h1w9gbxk	136	23	to	to	TO
cord-017764-h1w9gbxk	136	24	occur	occur	VB
cord-017764-h1w9gbxk	136	25	and	and	CC
cord-017764-h1w9gbxk	136	26	that	that	IN
cord-017764-h1w9gbxk	136	27	the	the	DT
cord-017764-h1w9gbxk	136	28	introduction	introduction	NN
cord-017764-h1w9gbxk	136	29	of	of	IN
cord-017764-h1w9gbxk	136	30	key	key	JJ
cord-017764-h1w9gbxk	136	31	resistant	resistant	JJ
cord-017764-h1w9gbxk	136	32	mutations	mutation	NNS
cord-017764-h1w9gbxk	136	33	leads	lead	VBZ
cord-017764-h1w9gbxk	136	34	to	to	IN
cord-017764-h1w9gbxk	136	35	only	only	RB
cord-017764-h1w9gbxk	136	36	a	a	DT
cord-017764-h1w9gbxk	136	37	modest	modest	JJ
cord-017764-h1w9gbxk	136	38	reduction	reduction	NN
cord-017764-h1w9gbxk	136	39	in	in	IN
cord-017764-h1w9gbxk	136	40	the	the	DT
cord-017764-h1w9gbxk	136	41	The	The	NNP
cord-017764-h1w9gbxk	136	42	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	136	43	and	and	CC
cord-017764-h1w9gbxk	136	44	Development	Development	NNP
cord-017764-h1w9gbxk	136	45	of	of	IN
cord-017764-h1w9gbxk	136	46	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	136	47	:	:	:
cord-017764-h1w9gbxk	137	1	An	an	DT
cord-017764-h1w9gbxk	137	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	137	3	of	of	IN
cord-017764-h1w9gbxk	137	4	the	the	DT
cord-017764-h1w9gbxk	137	5	.	.	.
cord-017764-h1w9gbxk	137	6	.	.	.
cord-017764-h1w9gbxk	137	7	.	.	.
cord-017764-h1w9gbxk	138	1	binding	bind	VBG
cord-017764-h1w9gbxk	138	2	of	of	IN
cord-017764-h1w9gbxk	138	3	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	138	4	[	[	-LRB-
cord-017764-h1w9gbxk	138	5	60	60	CD
cord-017764-h1w9gbxk	138	6	,	,	,
cord-017764-h1w9gbxk	138	7	61	61	CD
cord-017764-h1w9gbxk	138	8	]	]	-RRB-
cord-017764-h1w9gbxk	138	9	.	.	.
cord-017764-h1w9gbxk	139	1	Studies	study	NNS
cord-017764-h1w9gbxk	139	2	with	with	IN
cord-017764-h1w9gbxk	139	3	50	50	CD
cord-017764-h1w9gbxk	139	4	in	in	IN
cord-017764-h1w9gbxk	139	5	resistant	resistant	JJ
cord-017764-h1w9gbxk	139	6	GT-1b	GT-1b	NNS
cord-017764-h1w9gbxk	139	7	replicons	replicon	NNS
cord-017764-h1w9gbxk	139	8	indicated	indicate	VBD
cord-017764-h1w9gbxk	139	9	that	that	IN
cord-017764-h1w9gbxk	139	10	while	while	IN
cord-017764-h1w9gbxk	139	11	the	the	DT
cord-017764-h1w9gbxk	139	12	Tyr93His	tyr93hi	VBN
cord-017764-h1w9gbxk	139	13	-	-	HYPH
cord-017764-h1w9gbxk	139	14	resistant	resistant	JJ
cord-017764-h1w9gbxk	139	15	mutation	mutation	NN
cord-017764-h1w9gbxk	139	16	reduced	reduce	VBD
cord-017764-h1w9gbxk	139	17	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	139	18	potency	potency	NN
cord-017764-h1w9gbxk	139	19	by	by	IN
cord-017764-h1w9gbxk	139	20	220-fold	220-fold	CD
cord-017764-h1w9gbxk	139	21	,	,	,
cord-017764-h1w9gbxk	139	22	an	an	DT
cord-017764-h1w9gbxk	139	23	estimate	estimate	NN
cord-017764-h1w9gbxk	139	24	of	of	IN
cord-017764-h1w9gbxk	139	25	the	the	DT
cord-017764-h1w9gbxk	139	26	amount	amount	NN
cord-017764-h1w9gbxk	139	27	of	of	IN
cord-017764-h1w9gbxk	139	28	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	139	29	protein	protein	NN
cord-017764-h1w9gbxk	139	30	pulled	pull	VBD
cord-017764-h1w9gbxk	139	31	down	down	RP
cord-017764-h1w9gbxk	139	32	by	by	IN
cord-017764-h1w9gbxk	139	33	the	the	DT
cord-017764-h1w9gbxk	139	34	chemical	chemical	NN
cord-017764-h1w9gbxk	139	35	probe	probe	NN
cord-017764-h1w9gbxk	139	36	,	,	,
cord-017764-h1w9gbxk	139	37	as	as	IN
cord-017764-h1w9gbxk	139	38	determined	determine	VBN
cord-017764-h1w9gbxk	139	39	by	by	IN
cord-017764-h1w9gbxk	139	40	an	an	DT
cord-017764-h1w9gbxk	139	41	analysis	analysis	NN
cord-017764-h1w9gbxk	139	42	of	of	IN
cord-017764-h1w9gbxk	139	43	Western	western	JJ
cord-017764-h1w9gbxk	139	44	blots	blot	NNS
cord-017764-h1w9gbxk	139	45	,	,	,
cord-017764-h1w9gbxk	139	46	suggested	suggest	VBD
cord-017764-h1w9gbxk	139	47	similar	similar	JJ
cord-017764-h1w9gbxk	139	48	levels	level	NNS
cord-017764-h1w9gbxk	139	49	of	of	IN
cord-017764-h1w9gbxk	139	50	protein	protein	NN
cord-017764-h1w9gbxk	139	51	-	-	HYPH
cord-017764-h1w9gbxk	139	52	drug	drug	NN
cord-017764-h1w9gbxk	139	53	association	association	NN
cord-017764-h1w9gbxk	139	54	for	for	IN
cord-017764-h1w9gbxk	139	55	the	the	DT
cord-017764-h1w9gbxk	139	56	resistant	resistant	JJ
cord-017764-h1w9gbxk	139	57	and	and	CC
cord-017764-h1w9gbxk	139	58	wild	wild	JJ
cord-017764-h1w9gbxk	139	59	-	-	HYPH
cord-017764-h1w9gbxk	139	60	type	type	NN
cord-017764-h1w9gbxk	139	61	strains	strain	NNS
cord-017764-h1w9gbxk	139	62	[	[	-LRB-
cord-017764-h1w9gbxk	139	63	60	60	CD
cord-017764-h1w9gbxk	139	64	,	,	,
cord-017764-h1w9gbxk	139	65	61	61	CD
cord-017764-h1w9gbxk	139	66	]	]	-RRB-
cord-017764-h1w9gbxk	139	67	.	.	.
cord-017764-h1w9gbxk	140	1	Adding	add	VBG
cord-017764-h1w9gbxk	140	2	further	far	RBR
cord-017764-h1w9gbxk	140	3	to	to	IN
cord-017764-h1w9gbxk	140	4	the	the	DT
cord-017764-h1w9gbxk	140	5	complexity	complexity	NN
cord-017764-h1w9gbxk	140	6	of	of	IN
cord-017764-h1w9gbxk	140	7	the	the	DT
cord-017764-h1w9gbxk	140	8	biochemistry	biochemistry	NN
cord-017764-h1w9gbxk	140	9	was	be	VBD
cord-017764-h1w9gbxk	140	10	the	the	DT
cord-017764-h1w9gbxk	140	11	observation	observation	NN
cord-017764-h1w9gbxk	140	12	that	that	IN
cord-017764-h1w9gbxk	140	13	in	in	IN
cord-017764-h1w9gbxk	140	14	a	a	DT
cord-017764-h1w9gbxk	140	15	protein	protein	NN
cord-017764-h1w9gbxk	140	16	pull	pull	NN
cord-017764-h1w9gbxk	140	17	-	-	HYPH
cord-017764-h1w9gbxk	140	18	down	down	RP
cord-017764-h1w9gbxk	140	19	experiment	experiment	NN
cord-017764-h1w9gbxk	140	20	,	,	,
cord-017764-h1w9gbxk	140	21	an	an	DT
cord-017764-h1w9gbxk	140	22	attempt	attempt	NN
cord-017764-h1w9gbxk	140	23	to	to	TO
cord-017764-h1w9gbxk	140	24	outcompete	outcompete	VB
cord-017764-h1w9gbxk	140	25	the	the	DT
cord-017764-h1w9gbxk	140	26	biotinylated	biotinylated	JJ
cord-017764-h1w9gbxk	140	27	tool	tool	NN
cord-017764-h1w9gbxk	140	28	compound	compound	NN
cord-017764-h1w9gbxk	140	29	50	50	CD
cord-017764-h1w9gbxk	140	30	with	with	IN
cord-017764-h1w9gbxk	140	31	a	a	DT
cord-017764-h1w9gbxk	140	32	non	non	JJ
cord-017764-h1w9gbxk	140	33	-	-	JJ
cord-017764-h1w9gbxk	140	34	biotinylated	biotinylated	JJ
cord-017764-h1w9gbxk	140	35	analogue	analogue	NN
cord-017764-h1w9gbxk	140	36	in	in	IN
cord-017764-h1w9gbxk	140	37	a	a	DT
cord-017764-h1w9gbxk	140	38	GT-1b	GT-1b	NNS
cord-017764-h1w9gbxk	140	39	Tyr93His	tyr93his	NN
cord-017764-h1w9gbxk	140	40	-	-	HYPH
cord-017764-h1w9gbxk	140	41	containing	contain	VBG
cord-017764-h1w9gbxk	140	42	mutant	mutant	NN
cord-017764-h1w9gbxk	140	43	(	(	-LRB-
cord-017764-h1w9gbxk	140	44	EC	EC	NNP
cord-017764-h1w9gbxk	140	45	50	50	CD
cord-017764-h1w9gbxk	140	46	¼	¼	CD
cord-017764-h1w9gbxk	140	47	290	290	CD
cord-017764-h1w9gbxk	140	48	nM	nm	NN
cord-017764-h1w9gbxk	140	49	for	for	IN
cord-017764-h1w9gbxk	140	50	stated	state	VBN
cord-017764-h1w9gbxk	140	51	analogue	analogue	NN
cord-017764-h1w9gbxk	140	52	vs	vs	IN
cord-017764-h1w9gbxk	140	53	>	>	XX
cord-017764-h1w9gbxk	140	54	7	7	CD
cord-017764-h1w9gbxk	140	55	μM	μm	NN
cord-017764-h1w9gbxk	140	56	for	for	IN
cord-017764-h1w9gbxk	140	57	50	50	CD
cord-017764-h1w9gbxk	140	58	)	)	-RRB-
cord-017764-h1w9gbxk	140	59	not	not	RB
cord-017764-h1w9gbxk	140	60	only	only	RB
cord-017764-h1w9gbxk	140	61	failed	fail	VBN
cord-017764-h1w9gbxk	140	62	but	but	CC
cord-017764-h1w9gbxk	140	63	,	,	,
cord-017764-h1w9gbxk	140	64	at	at	IN
cord-017764-h1w9gbxk	140	65	low	low	JJ
cord-017764-h1w9gbxk	140	66	concentration	concentration	NN
cord-017764-h1w9gbxk	140	67	,	,	,
cord-017764-h1w9gbxk	140	68	appeared	appear	VBD
cord-017764-h1w9gbxk	140	69	to	to	TO
cord-017764-h1w9gbxk	140	70	have	have	VB
cord-017764-h1w9gbxk	140	71	incrementally	incrementally	RB
cord-017764-h1w9gbxk	140	72	enhanced	enhance	VBN
cord-017764-h1w9gbxk	140	73	the	the	DT
cord-017764-h1w9gbxk	140	74	amount	amount	NN
cord-017764-h1w9gbxk	140	75	of	of	IN
cord-017764-h1w9gbxk	140	76	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	140	77	pulled	pull	VBD
cord-017764-h1w9gbxk	140	78	down	down	RP
cord-017764-h1w9gbxk	140	79	.	.	.
cord-017764-h1w9gbxk	141	1	From	from	IN
cord-017764-h1w9gbxk	141	2	these	these	DT
cord-017764-h1w9gbxk	141	3	data	datum	NNS
cord-017764-h1w9gbxk	141	4	,	,	,
cord-017764-h1w9gbxk	141	5	it	-PRON-	PRP
cord-017764-h1w9gbxk	141	6	was	be	VBD
cord-017764-h1w9gbxk	141	7	inferred	infer	VBN
cord-017764-h1w9gbxk	141	8	that	that	IN
cord-017764-h1w9gbxk	141	9	the	the	DT
cord-017764-h1w9gbxk	141	10	development	development	NN
cord-017764-h1w9gbxk	141	11	of	of	IN
cord-017764-h1w9gbxk	141	12	resistance	resistance	NN
cord-017764-h1w9gbxk	141	13	to	to	IN
cord-017764-h1w9gbxk	141	14	1	1	CD
cord-017764-h1w9gbxk	141	15	does	do	VBZ
cord-017764-h1w9gbxk	141	16	not	not	RB
cord-017764-h1w9gbxk	141	17	lead	lead	VB
cord-017764-h1w9gbxk	141	18	to	to	IN
cord-017764-h1w9gbxk	141	19	exclusion	exclusion	NN
cord-017764-h1w9gbxk	141	20	of	of	IN
cord-017764-h1w9gbxk	141	21	binding	bind	VBG
cord-017764-h1w9gbxk	141	22	to	to	IN
cord-017764-h1w9gbxk	141	23	the	the	DT
cord-017764-h1w9gbxk	141	24	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	141	25	protein	protein	NN
cord-017764-h1w9gbxk	141	26	,	,	,
cord-017764-h1w9gbxk	141	27	as	as	IN
cord-017764-h1w9gbxk	141	28	is	be	VBZ
cord-017764-h1w9gbxk	141	29	often	often	RB
cord-017764-h1w9gbxk	141	30	observed	observe	VBN
cord-017764-h1w9gbxk	141	31	with	with	IN
cord-017764-h1w9gbxk	141	32	other	other	JJ
cord-017764-h1w9gbxk	141	33	classes	class	NNS
cord-017764-h1w9gbxk	141	34	of	of	IN
cord-017764-h1w9gbxk	141	35	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	141	36	agents	agent	NNS
cord-017764-h1w9gbxk	141	37	.	.	.
cord-017764-h1w9gbxk	142	1	Rather	rather	RB
cord-017764-h1w9gbxk	142	2	,	,	,
cord-017764-h1w9gbxk	142	3	these	these	DT
cord-017764-h1w9gbxk	142	4	observations	observation	NNS
cord-017764-h1w9gbxk	142	5	suggested	suggest	VBD
cord-017764-h1w9gbxk	142	6	a	a	DT
cord-017764-h1w9gbxk	142	7	scenario	scenario	NN
cord-017764-h1w9gbxk	142	8	in	in	IN
cord-017764-h1w9gbxk	142	9	which	which	WDT
cord-017764-h1w9gbxk	142	10	HCV	HCV	NNP
cord-017764-h1w9gbxk	142	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	142	12	develops	develop	VBZ
cord-017764-h1w9gbxk	142	13	resistance	resistance	NN
cord-017764-h1w9gbxk	142	14	by	by	IN
cord-017764-h1w9gbxk	142	15	accommodating	accommodate	VBG
cord-017764-h1w9gbxk	142	16	rather	rather	RB
cord-017764-h1w9gbxk	142	17	than	than	IN
cord-017764-h1w9gbxk	142	18	expelling	expel	VBG
cord-017764-h1w9gbxk	142	19	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	142	20	,	,	,
cord-017764-h1w9gbxk	142	21	with	with	IN
cord-017764-h1w9gbxk	142	22	the	the	DT
cord-017764-h1w9gbxk	142	23	mutations	mutation	NNS
cord-017764-h1w9gbxk	142	24	presumably	presumably	RB
cord-017764-h1w9gbxk	142	25	allowing	allow	VBG
cord-017764-h1w9gbxk	142	26	restoration	restoration	NN
cord-017764-h1w9gbxk	142	27	of	of	IN
cord-017764-h1w9gbxk	142	28	protein	protein	NN
cord-017764-h1w9gbxk	142	29	function	function	NN
cord-017764-h1w9gbxk	142	30	in	in	IN
cord-017764-h1w9gbxk	142	31	the	the	DT
cord-017764-h1w9gbxk	142	32	presence	presence	NN
cord-017764-h1w9gbxk	142	33	of	of	IN
cord-017764-h1w9gbxk	142	34	the	the	DT
cord-017764-h1w9gbxk	142	35	bound	bind	VBN
cord-017764-h1w9gbxk	142	36	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	142	37	.	.	.
cord-017764-h1w9gbxk	143	1	Consistent	consistent	JJ
cord-017764-h1w9gbxk	143	2	with	with	IN
cord-017764-h1w9gbxk	143	3	this	this	DT
cord-017764-h1w9gbxk	143	4	suggestion	suggestion	NN
cord-017764-h1w9gbxk	143	5	,	,	,
cord-017764-h1w9gbxk	143	6	several	several	JJ
cord-017764-h1w9gbxk	143	7	of	of	IN
cord-017764-h1w9gbxk	143	8	the	the	DT
cord-017764-h1w9gbxk	143	9	resistant	resistant	JJ
cord-017764-h1w9gbxk	143	10	mutations	mutation	NNS
cord-017764-h1w9gbxk	143	11	incorporate	incorporate	VBP
cord-017764-h1w9gbxk	143	12	smaller	small	JJR
cord-017764-h1w9gbxk	143	13	or	or	CC
cord-017764-h1w9gbxk	143	14	more	more	RBR
cord-017764-h1w9gbxk	143	15	flexible	flexible	JJ
cord-017764-h1w9gbxk	143	16	amino	amino	NN
cord-017764-h1w9gbxk	143	17	acid	acid	NN
cord-017764-h1w9gbxk	143	18	side	side	NN
cord-017764-h1w9gbxk	143	19	chains	chain	NNS
cord-017764-h1w9gbxk	143	20	,	,	,
cord-017764-h1w9gbxk	143	21	exemplified	exemplify	VBN
cord-017764-h1w9gbxk	143	22	by	by	IN
cord-017764-h1w9gbxk	143	23	Tyr93His	Tyr93His	NNP
cord-017764-h1w9gbxk	143	24	,	,	,
cord-017764-h1w9gbxk	143	25	Tyr93Cys	Tyr93Cys	NNP
cord-017764-h1w9gbxk	143	26	,	,	,
cord-017764-h1w9gbxk	143	27	Leu31Met	Leu31Met	NNP
cord-017764-h1w9gbxk	143	28	,	,	,
cord-017764-h1w9gbxk	143	29	and	and	CC
cord-017764-h1w9gbxk	143	30	Leu31Val	Leu31Val	NNS
cord-017764-h1w9gbxk	143	31	,	,	,
cord-017764-h1w9gbxk	143	32	which	which	WDT
cord-017764-h1w9gbxk	143	33	may	may	MD
cord-017764-h1w9gbxk	143	34	restore	restore	VB
cord-017764-h1w9gbxk	143	35	conformational	conformational	JJ
cord-017764-h1w9gbxk	143	36	flexibility	flexibility	NN
cord-017764-h1w9gbxk	143	37	compromised	compromise	VBN
cord-017764-h1w9gbxk	143	38	by	by	IN
cord-017764-h1w9gbxk	143	39	the	the	DT
cord-017764-h1w9gbxk	143	40	binding	binding	NN
cord-017764-h1w9gbxk	143	41	of	of	IN
cord-017764-h1w9gbxk	143	42	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	143	43	.	.	.
cord-017764-h1w9gbxk	144	1	These	these	DT
cord-017764-h1w9gbxk	144	2	observations	observation	NNS
cord-017764-h1w9gbxk	144	3	stimulated	stimulate	VBD
cord-017764-h1w9gbxk	144	4	an	an	DT
cord-017764-h1w9gbxk	144	5	experiment	experiment	NN
cord-017764-h1w9gbxk	144	6	designed	design	VBN
cord-017764-h1w9gbxk	144	7	to	to	TO
cord-017764-h1w9gbxk	144	8	evaluate	evaluate	VB
cord-017764-h1w9gbxk	144	9	the	the	DT
cord-017764-h1w9gbxk	144	10	effect	effect	NN
cord-017764-h1w9gbxk	144	11	of	of	IN
cord-017764-h1w9gbxk	144	12	combining	combine	VBG
cord-017764-h1w9gbxk	144	13	1	1	CD
cord-017764-h1w9gbxk	144	14	with	with	IN
cord-017764-h1w9gbxk	144	15	structurally	structurally	RB
cord-017764-h1w9gbxk	144	16	related	relate	VBN
cord-017764-h1w9gbxk	144	17	compounds	compound	NNS
cord-017764-h1w9gbxk	144	18	on	on	IN
cord-017764-h1w9gbxk	144	19	the	the	DT
cord-017764-h1w9gbxk	144	20	function	function	NN
cord-017764-h1w9gbxk	144	21	of	of	IN
cord-017764-h1w9gbxk	144	22	HCV	HCV	NNP
cord-017764-h1w9gbxk	144	23	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	144	24	incorporating	incorporate	VBG
cord-017764-h1w9gbxk	144	25	resistance	resistance	NN
cord-017764-h1w9gbxk	144	26	mutations	mutation	NNS
cord-017764-h1w9gbxk	144	27	.	.	.
cord-017764-h1w9gbxk	145	1	Two	two	CD
cord-017764-h1w9gbxk	145	2	possible	possible	JJ
cord-017764-h1w9gbxk	145	3	outcomes	outcome	NNS
cord-017764-h1w9gbxk	145	4	were	be	VBD
cord-017764-h1w9gbxk	145	5	contemplated	contemplate	VBN
cord-017764-h1w9gbxk	145	6	:	:	:
cord-017764-h1w9gbxk	145	7	in	in	IN
cord-017764-h1w9gbxk	145	8	the	the	DT
cord-017764-h1w9gbxk	145	9	first	first	JJ
cord-017764-h1w9gbxk	145	10	scenario	scenario	NN
cord-017764-h1w9gbxk	145	11	,	,	,
cord-017764-h1w9gbxk	145	12	a	a	DT
cord-017764-h1w9gbxk	145	13	molecule	molecule	NN
cord-017764-h1w9gbxk	145	14	would	would	MD
cord-017764-h1w9gbxk	145	15	simply	simply	RB
cord-017764-h1w9gbxk	145	16	compete	compete	VB
cord-017764-h1w9gbxk	145	17	with	with	IN
cord-017764-h1w9gbxk	145	18	bound	bind	VBN
cord-017764-h1w9gbxk	145	19	1	1	CD
cord-017764-h1w9gbxk	145	20	and	and	CC
cord-017764-h1w9gbxk	145	21	the	the	DT
cord-017764-h1w9gbxk	145	22	observed	observed	JJ
cord-017764-h1w9gbxk	145	23	effect	effect	NN
cord-017764-h1w9gbxk	145	24	would	would	MD
cord-017764-h1w9gbxk	145	25	be	be	VB
cord-017764-h1w9gbxk	145	26	one	one	CD
cord-017764-h1w9gbxk	145	27	of	of	IN
cord-017764-h1w9gbxk	145	28	silence	silence	NN
cord-017764-h1w9gbxk	145	29	.	.	.
cord-017764-h1w9gbxk	146	1	However	however	RB
cord-017764-h1w9gbxk	146	2	,	,	,
cord-017764-h1w9gbxk	146	3	the	the	DT
cord-017764-h1w9gbxk	146	4	alternative	alternative	JJ
cord-017764-h1w9gbxk	146	5	scenario	scenario	NN
cord-017764-h1w9gbxk	146	6	speculated	speculate	VBN
cord-017764-h1w9gbxk	146	7	on	on	IN
cord-017764-h1w9gbxk	146	8	the	the	DT
cord-017764-h1w9gbxk	146	9	potential	potential	NN
cord-017764-h1w9gbxk	146	10	of	of	IN
cord-017764-h1w9gbxk	146	11	a	a	DT
cord-017764-h1w9gbxk	146	12	second	second	JJ
cord-017764-h1w9gbxk	146	13	molecule	molecule	NN
cord-017764-h1w9gbxk	146	14	to	to	TO
cord-017764-h1w9gbxk	146	15	act	act	VB
cord-017764-h1w9gbxk	146	16	in	in	IN
cord-017764-h1w9gbxk	146	17	conjunction	conjunction	NN
cord-017764-h1w9gbxk	146	18	with	with	IN
cord-017764-h1w9gbxk	146	19	1	1	CD
cord-017764-h1w9gbxk	146	20	to	to	TO
cord-017764-h1w9gbxk	146	21	restore	restore	VB
cord-017764-h1w9gbxk	146	22	inhibition	inhibition	NN
cord-017764-h1w9gbxk	146	23	by	by	IN
cord-017764-h1w9gbxk	146	24	binding	bind	VBG
cord-017764-h1w9gbxk	146	25	to	to	IN
cord-017764-h1w9gbxk	146	26	an	an	DT
cord-017764-h1w9gbxk	146	27	adjacent	adjacent	JJ
cord-017764-h1w9gbxk	146	28	site	site	NN
cord-017764-h1w9gbxk	146	29	on	on	IN
cord-017764-h1w9gbxk	146	30	the	the	DT
cord-017764-h1w9gbxk	146	31	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	146	32	molecule	molecule	NN
cord-017764-h1w9gbxk	146	33	.	.	.
cord-017764-h1w9gbxk	147	1	A	a	DT
cord-017764-h1w9gbxk	147	2	screen	screen	NN
cord-017764-h1w9gbxk	147	3	of	of	IN
cord-017764-h1w9gbxk	147	4	compounds	compound	NNS
cord-017764-h1w9gbxk	147	5	selected	select	VBN
cord-017764-h1w9gbxk	147	6	from	from	IN
cord-017764-h1w9gbxk	147	7	the	the	DT
cord-017764-h1w9gbxk	147	8	library	library	NN
cord-017764-h1w9gbxk	147	9	of	of	IN
cord-017764-h1w9gbxk	147	10	HCV	HCV	NNP
cord-017764-h1w9gbxk	148	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	148	2	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	148	3	assessed	assess	VBN
cord-017764-h1w9gbxk	148	4	in	in	IN
cord-017764-h1w9gbxk	148	5	the	the	DT
cord-017764-h1w9gbxk	148	6	presence	presence	NN
cord-017764-h1w9gbxk	148	7	of	of	IN
cord-017764-h1w9gbxk	148	8	1	1	CD
cord-017764-h1w9gbxk	148	9	using	use	VBG
cord-017764-h1w9gbxk	148	10	the	the	DT
cord-017764-h1w9gbxk	148	11	Tyr93Asn	tyr93asn	NN
cord-017764-h1w9gbxk	148	12	GT-1aresistant	gt-1aresistant	NN
cord-017764-h1w9gbxk	148	13	replicon	replicon	NN
cord-017764-h1w9gbxk	148	14	,	,	,
cord-017764-h1w9gbxk	148	15	followed	follow	VBN
cord-017764-h1w9gbxk	148	16	by	by	IN
cord-017764-h1w9gbxk	148	17	SAR	SAR	NNP
cord-017764-h1w9gbxk	148	18	optimization	optimization	NN
cord-017764-h1w9gbxk	148	19	,	,	,
cord-017764-h1w9gbxk	148	20	identified	identify	VBD
cord-017764-h1w9gbxk	148	21	Syn-395	Syn-395	NNP
cord-017764-h1w9gbxk	148	22	(	(	-LRB-
cord-017764-h1w9gbxk	148	23	52	52	CD
cord-017764-h1w9gbxk	148	24	)	)	-RRB-
cord-017764-h1w9gbxk	148	25	as	as	IN
cord-017764-h1w9gbxk	148	26	a	a	DT
cord-017764-h1w9gbxk	148	27	molecule	molecule	NN
cord-017764-h1w9gbxk	148	28	capable	capable	JJ
cord-017764-h1w9gbxk	148	29	of	of	IN
cord-017764-h1w9gbxk	148	30	restoring	restore	VBG
cord-017764-h1w9gbxk	148	31	the	the	DT
cord-017764-h1w9gbxk	148	32	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	148	33	of	of	IN
cord-017764-h1w9gbxk	148	34	resistant	resistant	JJ
cord-017764-h1w9gbxk	148	35	virus	virus	NN
cord-017764-h1w9gbxk	148	36	to	to	IN
cord-017764-h1w9gbxk	148	37	the	the	DT
cord-017764-h1w9gbxk	148	38	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	148	39	effects	effect	NNS
cord-017764-h1w9gbxk	148	40	of	of	IN
cord-017764-h1w9gbxk	148	41	1	1	CD
cord-017764-h1w9gbxk	148	42	.	.	.
cord-017764-h1w9gbxk	149	1	For	for	IN
cord-017764-h1w9gbxk	149	2	example	example	NN
cord-017764-h1w9gbxk	149	3	,	,	,
cord-017764-h1w9gbxk	149	4	in	in	IN
cord-017764-h1w9gbxk	149	5	a	a	DT
cord-017764-h1w9gbxk	149	6	typical	typical	JJ
cord-017764-h1w9gbxk	149	7	experiment	experiment	NN
cord-017764-h1w9gbxk	149	8	,	,	,
cord-017764-h1w9gbxk	149	9	1	1	CD
cord-017764-h1w9gbxk	149	10	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	149	11	EC	EC	NNP
cord-017764-h1w9gbxk	149	12	50	50	CD
cord-017764-h1w9gbxk	149	13	values	value	NNS
cord-017764-h1w9gbxk	149	14	of	of	IN
cord-017764-h1w9gbxk	149	15	33	33	CD
cord-017764-h1w9gbxk	149	16	pM	pm	NN
cord-017764-h1w9gbxk	149	17	and	and	CC
cord-017764-h1w9gbxk	149	18	339	339	CD
cord-017764-h1w9gbxk	149	19	nM	nm	NN
cord-017764-h1w9gbxk	149	20	toward	toward	IN
cord-017764-h1w9gbxk	149	21	the	the	DT
cord-017764-h1w9gbxk	149	22	wild	wild	JJ
cord-017764-h1w9gbxk	149	23	type	type	NN
cord-017764-h1w9gbxk	149	24	and	and	CC
cord-017764-h1w9gbxk	149	25	Tyr93Asn	tyr93asn	NN
cord-017764-h1w9gbxk	149	26	mutant	mutant	JJ
cord-017764-h1w9gbxk	149	27	replicons	replicon	NNS
cord-017764-h1w9gbxk	149	28	,	,	,
cord-017764-h1w9gbxk	149	29	respectively	respectively	RB
cord-017764-h1w9gbxk	149	30	,	,	,
cord-017764-h1w9gbxk	149	31	whereas	whereas	IN
cord-017764-h1w9gbxk	149	32	52	52	CD
cord-017764-h1w9gbxk	149	33	was	be	VBD
cord-017764-h1w9gbxk	149	34	poorly	poorly	RB
cord-017764-h1w9gbxk	149	35	active	active	JJ
cord-017764-h1w9gbxk	149	36	in	in	IN
cord-017764-h1w9gbxk	149	37	both	both	DT
cord-017764-h1w9gbxk	149	38	replicons	replicon	NNS
cord-017764-h1w9gbxk	149	39	,	,	,
cord-017764-h1w9gbxk	149	40	with	with	IN
cord-017764-h1w9gbxk	149	41	EC	EC	NNP
cord-017764-h1w9gbxk	149	42	50	50	CD
cord-017764-h1w9gbxk	149	43	values	value	NNS
cord-017764-h1w9gbxk	149	44	of	of	IN
cord-017764-h1w9gbxk	149	45	214	214	CD
cord-017764-h1w9gbxk	149	46	and	and	CC
cord-017764-h1w9gbxk	149	47	215	215	CD
cord-017764-h1w9gbxk	149	48	nM	nM	NNS
cord-017764-h1w9gbxk	149	49	,	,	,
cord-017764-h1w9gbxk	149	50	respectively	respectively	RB
cord-017764-h1w9gbxk	149	51	.	.	.
cord-017764-h1w9gbxk	150	1	However	however	RB
cord-017764-h1w9gbxk	150	2	,	,	,
cord-017764-h1w9gbxk	150	3	the	the	DT
cord-017764-h1w9gbxk	150	4	EC	EC	NNP
cord-017764-h1w9gbxk	150	5	50	50	CD
cord-017764-h1w9gbxk	150	6	of	of	IN
cord-017764-h1w9gbxk	150	7	1	1	CD
cord-017764-h1w9gbxk	150	8	toward	toward	IN
cord-017764-h1w9gbxk	150	9	the	the	DT
cord-017764-h1w9gbxk	150	10	Tyr93Asn	Tyr93Asn	NNP
cord-017764-h1w9gbxk	150	11	mutant	mutant	JJ
cord-017764-h1w9gbxk	150	12	replicon	replicon	NN
cord-017764-h1w9gbxk	150	13	improved	improve	VBD
cord-017764-h1w9gbxk	150	14	to	to	IN
cord-017764-h1w9gbxk	150	15	0.13	0.13	CD
cord-017764-h1w9gbxk	150	16	nM	nm	NN
cord-017764-h1w9gbxk	150	17	when	when	WRB
cord-017764-h1w9gbxk	150	18	titrated	titrate	VBN
cord-017764-h1w9gbxk	150	19	in	in	IN
cord-017764-h1w9gbxk	150	20	the	the	DT
cord-017764-h1w9gbxk	150	21	presence	presence	NN
cord-017764-h1w9gbxk	150	22	of	of	IN
cord-017764-h1w9gbxk	150	23	a	a	DT
cord-017764-h1w9gbxk	150	24	suboptimal	suboptimal	JJ
cord-017764-h1w9gbxk	150	25	concentration	concentration	NN
cord-017764-h1w9gbxk	150	26	(	(	-LRB-
cord-017764-h1w9gbxk	150	27	40	40	CD
cord-017764-h1w9gbxk	150	28	nM	nM	NNP
cord-017764-h1w9gbxk	150	29	)	)	-RRB-
cord-017764-h1w9gbxk	150	30	of	of	IN
cord-017764-h1w9gbxk	150	31	52	52	CD
cord-017764-h1w9gbxk	150	32	.	.	.
cord-017764-h1w9gbxk	151	1	This	this	DT
cord-017764-h1w9gbxk	151	2	result	result	NN
cord-017764-h1w9gbxk	151	3	represented	represent	VBD
cord-017764-h1w9gbxk	151	4	a	a	DT
cord-017764-h1w9gbxk	151	5	2,600-fold	2,600-fold	CD
cord-017764-h1w9gbxk	151	6	increase	increase	NN
cord-017764-h1w9gbxk	151	7	in	in	IN
cord-017764-h1w9gbxk	151	8	the	the	DT
cord-017764-h1w9gbxk	151	9	sensitivity	sensitivity	NN
cord-017764-h1w9gbxk	151	10	of	of	IN
cord-017764-h1w9gbxk	151	11	the	the	DT
cord-017764-h1w9gbxk	151	12	Tyr93Asn	tyr93asn	NN
cord-017764-h1w9gbxk	151	13	replicon	replicon	NN
cord-017764-h1w9gbxk	151	14	to	to	IN
cord-017764-h1w9gbxk	151	15	1	1	CD
cord-017764-h1w9gbxk	151	16	in	in	IN
cord-017764-h1w9gbxk	151	17	the	the	DT
cord-017764-h1w9gbxk	151	18	presence	presence	NN
cord-017764-h1w9gbxk	151	19	of	of	IN
cord-017764-h1w9gbxk	151	20	52	52	CD
cord-017764-h1w9gbxk	151	21	.	.	.
cord-017764-h1w9gbxk	152	1	The	the	DT
cord-017764-h1w9gbxk	152	2	synergistic	synergistic	JJ
cord-017764-h1w9gbxk	152	3	relationship	relationship	NN
cord-017764-h1w9gbxk	152	4	between	between	IN
cord-017764-h1w9gbxk	152	5	1	1	CD
cord-017764-h1w9gbxk	152	6	and	and	CC
cord-017764-h1w9gbxk	152	7	52	52	CD
cord-017764-h1w9gbxk	152	8	was	be	VBD
cord-017764-h1w9gbxk	152	9	confirmed	confirm	VBN
cord-017764-h1w9gbxk	152	10	in	in	IN
cord-017764-h1w9gbxk	152	11	a	a	DT
cord-017764-h1w9gbxk	152	12	reciprocal	reciprocal	JJ
cord-017764-h1w9gbxk	152	13	experiment	experiment	NN
cord-017764-h1w9gbxk	152	14	where	where	WRB
cord-017764-h1w9gbxk	152	15	52	52	CD
cord-017764-h1w9gbxk	152	16	was	be	VBD
cord-017764-h1w9gbxk	152	17	titrated	titrate	VBN
cord-017764-h1w9gbxk	152	18	in	in	IN
cord-017764-h1w9gbxk	152	19	the	the	DT
cord-017764-h1w9gbxk	152	20	presence	presence	NN
cord-017764-h1w9gbxk	152	21	of	of	IN
cord-017764-h1w9gbxk	152	22	suboptimal	suboptimal	JJ
cord-017764-h1w9gbxk	152	23	amount	amount	NN
cord-017764-h1w9gbxk	152	24	of	of	IN
cord-017764-h1w9gbxk	152	25	1	1	CD
cord-017764-h1w9gbxk	152	26	affording	afford	VBG
cord-017764-h1w9gbxk	152	27	a	a	DT
cord-017764-h1w9gbxk	152	28	similar	similar	JJ
cord-017764-h1w9gbxk	152	29	outcome	outcome	NN
cord-017764-h1w9gbxk	152	30	[	[	-LRB-
cord-017764-h1w9gbxk	152	31	60	60	CD
cord-017764-h1w9gbxk	152	32	,	,	,
cord-017764-h1w9gbxk	152	33	61	61	CD
cord-017764-h1w9gbxk	152	34	]	]	-RRB-
cord-017764-h1w9gbxk	152	35	.	.	.
cord-017764-h1w9gbxk	153	1	This	this	DT
cord-017764-h1w9gbxk	153	2	has	have	VBZ
cord-017764-h1w9gbxk	153	3	presented	present	VBN
cord-017764-h1w9gbxk	153	4	a	a	DT
cord-017764-h1w9gbxk	153	5	significant	significant	JJ
cord-017764-h1w9gbxk	153	6	challenge	challenge	NN
cord-017764-h1w9gbxk	153	7	to	to	IN
cord-017764-h1w9gbxk	153	8	developing	develop	VBG
cord-017764-h1w9gbxk	153	9	a	a	DT
cord-017764-h1w9gbxk	153	10	more	more	RBR
cord-017764-h1w9gbxk	153	11	coherent	coherent	JJ
cord-017764-h1w9gbxk	153	12	and	and	CC
cord-017764-h1w9gbxk	153	13	detailed	detailed	JJ
cord-017764-h1w9gbxk	153	14	understanding	understanding	NN
cord-017764-h1w9gbxk	153	15	of	of	IN
cord-017764-h1w9gbxk	153	16	the	the	DT
cord-017764-h1w9gbxk	153	17	mechanism	mechanism	NN
cord-017764-h1w9gbxk	153	18	of	of	IN
cord-017764-h1w9gbxk	153	19	action	action	NN
cord-017764-h1w9gbxk	153	20	of	of	IN
cord-017764-h1w9gbxk	153	21	HCV	HCV	NNP
cord-017764-h1w9gbxk	154	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	154	2	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	154	3	and	and	CC
cord-017764-h1w9gbxk	154	4	the	the	DT
cord-017764-h1w9gbxk	154	5	modeling	modeling	NN
cord-017764-h1w9gbxk	154	6	of	of	IN
cord-017764-h1w9gbxk	154	7	drug	drug	NN
cord-017764-h1w9gbxk	154	8	-	-	HYPH
cord-017764-h1w9gbxk	154	9	target	target	NN
cord-017764-h1w9gbxk	154	10	interactions	interaction	NNS
cord-017764-h1w9gbxk	154	11	of	of	IN
cord-017764-h1w9gbxk	154	12	these	these	DT
cord-017764-h1w9gbxk	154	13	potent	potent	JJ
cord-017764-h1w9gbxk	154	14	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	154	15	agents	agent	NNS
cord-017764-h1w9gbxk	154	16	and	and	CC
cord-017764-h1w9gbxk	154	17	the	the	DT
cord-017764-h1w9gbxk	154	18	allosteric	allosteric	JJ
cord-017764-h1w9gbxk	154	19	modulators	modulator	NNS
cord-017764-h1w9gbxk	154	20	[	[	-LRB-
cord-017764-h1w9gbxk	154	21	60	60	CD
cord-017764-h1w9gbxk	154	22	]	]	-RRB-
cord-017764-h1w9gbxk	154	23	[	[	-LRB-
cord-017764-h1w9gbxk	154	24	61	61	CD
cord-017764-h1w9gbxk	154	25	]	]	-RRB-
cord-017764-h1w9gbxk	154	26	[	[	-LRB-
cord-017764-h1w9gbxk	154	27	62	62	CD
cord-017764-h1w9gbxk	154	28	]	]	-RRB-
cord-017764-h1w9gbxk	154	29	[	[	-LRB-
cord-017764-h1w9gbxk	154	30	63	63	CD
cord-017764-h1w9gbxk	154	31	]	]	-RRB-
cord-017764-h1w9gbxk	154	32	[	[	-LRB-
cord-017764-h1w9gbxk	154	33	64	64	CD
cord-017764-h1w9gbxk	154	34	]	]	-RRB-
cord-017764-h1w9gbxk	154	35	[	[	-LRB-
cord-017764-h1w9gbxk	154	36	65	65	CD
cord-017764-h1w9gbxk	154	37	]	]	-RRB-
cord-017764-h1w9gbxk	155	1	[	[	-LRB-
cord-017764-h1w9gbxk	155	2	66	66	CD
cord-017764-h1w9gbxk	155	3	]	]	-RRB-
cord-017764-h1w9gbxk	155	4	[	[	-LRB-
cord-017764-h1w9gbxk	155	5	67	67	CD
cord-017764-h1w9gbxk	155	6	]	]	-RRB-
cord-017764-h1w9gbxk	155	7	.	.	.
cord-017764-h1w9gbxk	156	1	While	while	IN
cord-017764-h1w9gbxk	156	2	the	the	DT
cord-017764-h1w9gbxk	156	3	bivalent	bivalent	JJ
cord-017764-h1w9gbxk	156	4	nature	nature	NN
cord-017764-h1w9gbxk	156	5	of	of	IN
cord-017764-h1w9gbxk	156	6	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	156	7	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	156	8	,	,	,
cord-017764-h1w9gbxk	156	9	including	include	VBG
cord-017764-h1w9gbxk	156	10	the	the	DT
cord-017764-h1w9gbxk	156	11	allosteric	allosteric	JJ
cord-017764-h1w9gbxk	156	12	modulators	modulator	NNS
cord-017764-h1w9gbxk	156	13	represented	represent	VBN
cord-017764-h1w9gbxk	156	14	by	by	IN
cord-017764-h1w9gbxk	156	15	52	52	CD
cord-017764-h1w9gbxk	156	16	,	,	,
cord-017764-h1w9gbxk	156	17	complements	complement	VBZ
cord-017764-h1w9gbxk	156	18	the	the	DT
cord-017764-h1w9gbxk	156	19	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	156	20	form	form	NN
cord-017764-h1w9gbxk	156	21	of	of	IN
cord-017764-h1w9gbxk	156	22	the	the	DT
cord-017764-h1w9gbxk	156	23	protein	protein	NN
cord-017764-h1w9gbxk	156	24	observed	observe	VBD
cord-017764-h1w9gbxk	156	25	in	in	IN
cord-017764-h1w9gbxk	156	26	solid	solid	JJ
cord-017764-h1w9gbxk	156	27	-	-	HYPH
cord-017764-h1w9gbxk	156	28	state	state	NN
cord-017764-h1w9gbxk	156	29	structures	structure	NNS
cord-017764-h1w9gbxk	156	30	of	of	IN
cord-017764-h1w9gbxk	156	31	elements	element	NNS
cord-017764-h1w9gbxk	156	32	of	of	IN
cord-017764-h1w9gbxk	156	33	domain	domain	NN
cord-017764-h1w9gbxk	157	1	I	-PRON-	PRP
cord-017764-h1w9gbxk	157	2	,	,	,
cord-017764-h1w9gbxk	157	3	the	the	DT
cord-017764-h1w9gbxk	157	4	binding	bind	VBG
cord-017764-h1w9gbxk	157	5	interfaces	interface	NNS
cord-017764-h1w9gbxk	157	6	between	between	IN
cord-017764-h1w9gbxk	157	7	the	the	DT
cord-017764-h1w9gbxk	157	8	proteins	protein	NNS
cord-017764-h1w9gbxk	157	9	vary	vary	VBP
cord-017764-h1w9gbxk	157	10	[	[	-LRB-
cord-017764-h1w9gbxk	157	11	26	26	CD
cord-017764-h1w9gbxk	157	12	-	-	SYM
cord-017764-h1w9gbxk	157	13	28	28	CD
cord-017764-h1w9gbxk	157	14	,	,	,
cord-017764-h1w9gbxk	157	15	60	60	CD
cord-017764-h1w9gbxk	157	16	,	,	,
cord-017764-h1w9gbxk	157	17	61	61	CD
cord-017764-h1w9gbxk	157	18	]	]	-RRB-
cord-017764-h1w9gbxk	157	19	.	.	.
cord-017764-h1w9gbxk	158	1	One	one	CD
cord-017764-h1w9gbxk	158	2	interpretation	interpretation	NN
cord-017764-h1w9gbxk	158	3	of	of	IN
cord-017764-h1w9gbxk	158	4	this	this	DT
cord-017764-h1w9gbxk	158	5	observation	observation	NN
cord-017764-h1w9gbxk	158	6	anticipates	anticipate	VBZ
cord-017764-h1w9gbxk	158	7	an	an	DT
cord-017764-h1w9gbxk	158	8	oligomeric	oligomeric	JJ
cord-017764-h1w9gbxk	158	9	form	form	NN
cord-017764-h1w9gbxk	158	10	of	of	IN
cord-017764-h1w9gbxk	158	11	HCV	HCV	NNP
cord-017764-h1w9gbxk	158	12	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	159	1	in	in	IN
cord-017764-h1w9gbxk	159	2	cells	cell	NNS
cord-017764-h1w9gbxk	159	3	that	that	WDT
cord-017764-h1w9gbxk	159	4	can	can	MD
cord-017764-h1w9gbxk	159	5	bind	bind	VB
cord-017764-h1w9gbxk	159	6	to	to	IN
cord-017764-h1w9gbxk	159	7	the	the	DT
cord-017764-h1w9gbxk	159	8	viral	viral	JJ
cord-017764-h1w9gbxk	159	9	RNA	RNA	NNP
cord-017764-h1w9gbxk	159	10	and	and	CC
cord-017764-h1w9gbxk	159	11	protect	protect	VB
cord-017764-h1w9gbxk	159	12	it	-PRON-	PRP
cord-017764-h1w9gbxk	159	13	from	from	IN
cord-017764-h1w9gbxk	159	14	chemical	chemical	JJ
cord-017764-h1w9gbxk	159	15	and	and	CC
cord-017764-h1w9gbxk	159	16	enzymatic	enzymatic	JJ
cord-017764-h1w9gbxk	159	17	degradation	degradation	NN
cord-017764-h1w9gbxk	159	18	while	while	IN
cord-017764-h1w9gbxk	159	19	providing	provide	VBG
cord-017764-h1w9gbxk	159	20	a	a	DT
cord-017764-h1w9gbxk	159	21	platform	platform	NN
cord-017764-h1w9gbxk	159	22	for	for	IN
cord-017764-h1w9gbxk	159	23	RNA	RNA	NNP
cord-017764-h1w9gbxk	159	24	presentation	presentation	NN
cord-017764-h1w9gbxk	159	25	to	to	IN
cord-017764-h1w9gbxk	159	26	the	the	DT
cord-017764-h1w9gbxk	159	27	polymerase	polymerase	NN
cord-017764-h1w9gbxk	159	28	and	and	CC
cord-017764-h1w9gbxk	159	29	translocation	translocation	NN
cord-017764-h1w9gbxk	159	30	to	to	IN
cord-017764-h1w9gbxk	159	31	the	the	DT
cord-017764-h1w9gbxk	159	32	developing	develop	VBG
cord-017764-h1w9gbxk	159	33	virion	virion	NN
cord-017764-h1w9gbxk	159	34	[	[	-LRB-
cord-017764-h1w9gbxk	159	35	68	68	CD
cord-017764-h1w9gbxk	159	36	]	]	-RRB-
cord-017764-h1w9gbxk	160	1	[	[	-LRB-
cord-017764-h1w9gbxk	160	2	69	69	CD
cord-017764-h1w9gbxk	160	3	]	]	-RRB-
cord-017764-h1w9gbxk	160	4	[	[	-LRB-
cord-017764-h1w9gbxk	160	5	70	70	CD
cord-017764-h1w9gbxk	160	6	]	]	-RRB-
cord-017764-h1w9gbxk	160	7	.	.	.
cord-017764-h1w9gbxk	161	1	However	however	RB
cord-017764-h1w9gbxk	161	2	,	,	,
cord-017764-h1w9gbxk	161	3	the	the	DT
cord-017764-h1w9gbxk	161	4	biochemical	biochemical	JJ
cord-017764-h1w9gbxk	161	5	pharmacological	pharmacological	JJ
cord-017764-h1w9gbxk	161	6	effects	effect	NNS
cord-017764-h1w9gbxk	161	7	of	of	IN
cord-017764-h1w9gbxk	161	8	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	161	9	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	161	10	are	be	VBP
cord-017764-h1w9gbxk	161	11	multifaceted	multifaceted	JJ
cord-017764-h1w9gbxk	161	12	and	and	CC
cord-017764-h1w9gbxk	161	13	complex	complex	JJ
cord-017764-h1w9gbxk	161	14	and	and	CC
cord-017764-h1w9gbxk	161	15	include	include	VBP
cord-017764-h1w9gbxk	161	16	altering	alter	VBG
cord-017764-h1w9gbxk	161	17	the	the	DT
cord-017764-h1w9gbxk	161	18	subcellular	subcellular	JJ
cord-017764-h1w9gbxk	161	19	distribution	distribution	NN
cord-017764-h1w9gbxk	161	20	of	of	IN
cord-017764-h1w9gbxk	161	21	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	161	22	,	,	,
cord-017764-h1w9gbxk	161	23	modulating	modulate	VBG
cord-017764-h1w9gbxk	161	24	the	the	DT
cord-017764-h1w9gbxk	161	25	phosphorylation	phosphorylation	NN
cord-017764-h1w9gbxk	161	26	state	state	NN
cord-017764-h1w9gbxk	161	27	of	of	IN
cord-017764-h1w9gbxk	161	28	the	the	DT
cord-017764-h1w9gbxk	161	29	protein	protein	NN
cord-017764-h1w9gbxk	161	30	,	,	,
cord-017764-h1w9gbxk	161	31	interfering	interfere	VBG
cord-017764-h1w9gbxk	161	32	with	with	IN
cord-017764-h1w9gbxk	161	33	the	the	DT
cord-017764-h1w9gbxk	161	34	formation	formation	NN
cord-017764-h1w9gbxk	161	35	of	of	IN
cord-017764-h1w9gbxk	161	36	the	the	DT
cord-017764-h1w9gbxk	161	37	membranous	membranous	JJ
cord-017764-h1w9gbxk	161	38	factories	factory	NNS
cord-017764-h1w9gbxk	161	39	where	where	WRB
cord-017764-h1w9gbxk	161	40	virus	virus	NN
cord-017764-h1w9gbxk	161	41	replication	replication	NN
cord-017764-h1w9gbxk	161	42	occurs	occur	VBZ
cord-017764-h1w9gbxk	161	43	,	,	,
cord-017764-h1w9gbxk	161	44	and	and	CC
cord-017764-h1w9gbxk	161	45	blocking	block	VBG
cord-017764-h1w9gbxk	161	46	the	the	DT
cord-017764-h1w9gbxk	161	47	transfer	transfer	NN
cord-017764-h1w9gbxk	161	48	of	of	IN
cord-017764-h1w9gbxk	161	49	the	the	DT
cord-017764-h1w9gbxk	161	50	viral	viral	JJ
cord-017764-h1w9gbxk	161	51	genome	genome	NN
cord-017764-h1w9gbxk	161	52	to	to	IN
cord-017764-h1w9gbxk	161	53	assembly	assembly	NN
cord-017764-h1w9gbxk	161	54	proteins	protein	NNS
cord-017764-h1w9gbxk	161	55	,	,	,
cord-017764-h1w9gbxk	161	56	leading	lead	VBG
cord-017764-h1w9gbxk	161	57	to	to	IN
cord-017764-h1w9gbxk	161	58	a	a	DT
cord-017764-h1w9gbxk	161	59	clustering	clustering	NN
cord-017764-h1w9gbxk	161	60	of	of	IN
cord-017764-h1w9gbxk	161	61	HCV	HCV	NNP
cord-017764-h1w9gbxk	161	62	proteins	protein	NNS
cord-017764-h1w9gbxk	161	63	at	at	IN
cord-017764-h1w9gbxk	161	64	endoplasmic	endoplasmic	NN
cord-017764-h1w9gbxk	161	65	reticulum	reticulum	NN
cord-017764-h1w9gbxk	161	66	membranes	membrane	NNS
cord-017764-h1w9gbxk	161	67	[	[	-LRB-
cord-017764-h1w9gbxk	161	68	71	71	CD
cord-017764-h1w9gbxk	161	69	]	]	-RRB-
cord-017764-h1w9gbxk	161	70	[	[	-LRB-
cord-017764-h1w9gbxk	161	71	72	72	CD
cord-017764-h1w9gbxk	161	72	]	]	-RRB-
cord-017764-h1w9gbxk	162	1	[	[	-LRB-
cord-017764-h1w9gbxk	162	2	73	73	CD
cord-017764-h1w9gbxk	162	3	]	]	-RRB-
cord-017764-h1w9gbxk	163	1	[	[	-LRB-
cord-017764-h1w9gbxk	163	2	74	74	CD
cord-017764-h1w9gbxk	163	3	]	]	-RRB-
cord-017764-h1w9gbxk	164	1	[	[	-LRB-
cord-017764-h1w9gbxk	164	2	75	75	CD
cord-017764-h1w9gbxk	164	3	]	]	-RRB-
cord-017764-h1w9gbxk	164	4	[	[	-LRB-
cord-017764-h1w9gbxk	164	5	76	76	CD
cord-017764-h1w9gbxk	164	6	]	]	-RRB-
cord-017764-h1w9gbxk	164	7	.	.	.
cord-017764-h1w9gbxk	165	1	The	the	DT
cord-017764-h1w9gbxk	165	2	phase	phase	NN
cord-017764-h1w9gbxk	165	3	I	-PRON-	PRP
cord-017764-h1w9gbxk	165	4	clinical	clinical	JJ
cord-017764-h1w9gbxk	165	5	trial	trial	NN
cord-017764-h1w9gbxk	165	6	with	with	IN
cord-017764-h1w9gbxk	165	7	1	1	CD
cord-017764-h1w9gbxk	165	8	comprised	comprise	VBN
cord-017764-h1w9gbxk	165	9	of	of	IN
cord-017764-h1w9gbxk	165	10	a	a	DT
cord-017764-h1w9gbxk	165	11	randomized	randomized	JJ
cord-017764-h1w9gbxk	165	12	,	,	,
cord-017764-h1w9gbxk	165	13	double	double	JJ
cord-017764-h1w9gbxk	165	14	-	-	HYPH
cord-017764-h1w9gbxk	165	15	blind	blind	JJ
cord-017764-h1w9gbxk	165	16	,	,	,
cord-017764-h1w9gbxk	165	17	placebocontrolled	placebocontrolled	JJ
cord-017764-h1w9gbxk	165	18	,	,	,
cord-017764-h1w9gbxk	165	19	single	single	JJ
cord-017764-h1w9gbxk	165	20	ascending	ascend	VBG
cord-017764-h1w9gbxk	165	21	dose	dose	NN
cord-017764-h1w9gbxk	165	22	study	study	NN
cord-017764-h1w9gbxk	165	23	involving	involve	VBG
cord-017764-h1w9gbxk	165	24	administration	administration	NN
cord-017764-h1w9gbxk	165	25	of	of	IN
cord-017764-h1w9gbxk	165	26	1	1	CD
cord-017764-h1w9gbxk	165	27	,	,	,
cord-017764-h1w9gbxk	165	28	10	10	CD
cord-017764-h1w9gbxk	165	29	,	,	,
cord-017764-h1w9gbxk	165	30	25	25	CD
cord-017764-h1w9gbxk	165	31	,	,	,
cord-017764-h1w9gbxk	165	32	50	50	CD
cord-017764-h1w9gbxk	165	33	,	,	,
cord-017764-h1w9gbxk	165	34	100	100	CD
cord-017764-h1w9gbxk	165	35	,	,	,
cord-017764-h1w9gbxk	165	36	and	and	CC
cord-017764-h1w9gbxk	165	37	200	200	CD
cord-017764-h1w9gbxk	165	38	mg	mg	NN
cord-017764-h1w9gbxk	165	39	of	of	IN
cord-017764-h1w9gbxk	165	40	the	the	DT
cord-017764-h1w9gbxk	165	41	drug	drug	NN
cord-017764-h1w9gbxk	165	42	to	to	IN
cord-017764-h1w9gbxk	165	43	normal	normal	JJ
cord-017764-h1w9gbxk	165	44	healthy	healthy	JJ
cord-017764-h1w9gbxk	165	45	volunteers	volunteer	NNS
cord-017764-h1w9gbxk	165	46	(	(	-LRB-
cord-017764-h1w9gbxk	165	47	NHVs	NHVs	NNP
cord-017764-h1w9gbxk	165	48	)	)	-RRB-
cord-017764-h1w9gbxk	165	49	[	[	-LRB-
cord-017764-h1w9gbxk	165	50	3	3	CD
cord-017764-h1w9gbxk	165	51	]	]	-RRB-
cord-017764-h1w9gbxk	165	52	.	.	.
cord-017764-h1w9gbxk	166	1	A	a	DT
cord-017764-h1w9gbxk	166	2	doseproportional	doseproportional	JJ
cord-017764-h1w9gbxk	166	3	increase	increase	NN
cord-017764-h1w9gbxk	166	4	in	in	IN
cord-017764-h1w9gbxk	166	5	plasma	plasma	NN
cord-017764-h1w9gbxk	166	6	exposure	exposure	NN
cord-017764-h1w9gbxk	166	7	was	be	VBD
cord-017764-h1w9gbxk	166	8	observed	observe	VBN
cord-017764-h1w9gbxk	166	9	over	over	IN
cord-017764-h1w9gbxk	166	10	the	the	DT
cord-017764-h1w9gbxk	166	11	dosing	dosing	NN
cord-017764-h1w9gbxk	166	12	range	range	NN
cord-017764-h1w9gbxk	166	13	,	,	,
cord-017764-h1w9gbxk	166	14	and	and	CC
cord-017764-h1w9gbxk	166	15	the	the	DT
cord-017764-h1w9gbxk	166	16	concentration	concentration	NN
cord-017764-h1w9gbxk	166	17	of	of	IN
cord-017764-h1w9gbxk	166	18	1	1	CD
cord-017764-h1w9gbxk	166	19	in	in	IN
cord-017764-h1w9gbxk	166	20	plasma	plasma	NN
cord-017764-h1w9gbxk	166	21	24	24	CD
cord-017764-h1w9gbxk	166	22	h	h	NN
cord-017764-h1w9gbxk	166	23	after	after	IN
cord-017764-h1w9gbxk	166	24	dosing	dosing	NN
cord-017764-h1w9gbxk	166	25	exceeded	exceed	VBD
cord-017764-h1w9gbxk	166	26	the	the	DT
cord-017764-h1w9gbxk	166	27	protein	protein	NN
cord-017764-h1w9gbxk	166	28	-	-	HYPH
cord-017764-h1w9gbxk	166	29	bindingadjusted	bindingadjuste	VBN
cord-017764-h1w9gbxk	166	30	EC	EC	NNP
cord-017764-h1w9gbxk	166	31	90	90	CD
cord-017764-h1w9gbxk	166	32	values	value	NNS
cord-017764-h1w9gbxk	166	33	of	of	IN
cord-017764-h1w9gbxk	166	34	49	49	CD
cord-017764-h1w9gbxk	166	35	pM	pm	NN
cord-017764-h1w9gbxk	166	36	(	(	-LRB-
cord-017764-h1w9gbxk	166	37	0.04	0.04	CD
cord-017764-h1w9gbxk	166	38	ng	ng	NN
cord-017764-h1w9gbxk	166	39	/	/	SYM
cord-017764-h1w9gbxk	166	40	mL	mL	NNP
cord-017764-h1w9gbxk	166	41	)	)	-RRB-
cord-017764-h1w9gbxk	166	42	and	and	CC
cord-017764-h1w9gbxk	166	43	383	383	CD
cord-017764-h1w9gbxk	166	44	pM	pm	NN
cord-017764-h1w9gbxk	166	45	(	(	-LRB-
cord-017764-h1w9gbxk	166	46	0.28	0.28	CD
cord-017764-h1w9gbxk	166	47	ng	ng	NNP
cord-017764-h1w9gbxk	166	48	/	/	SYM
cord-017764-h1w9gbxk	166	49	mL	ml	NN
cord-017764-h1w9gbxk	166	50	)	)	-RRB-
cord-017764-h1w9gbxk	166	51	recorded	record	VBD
cord-017764-h1w9gbxk	166	52	for	for	IN
cord-017764-h1w9gbxk	166	53	the	the	DT
cord-017764-h1w9gbxk	166	54	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	166	55	and	and	CC
cord-017764-h1w9gbxk	166	56	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	166	57	replicons	replicon	NNS
cord-017764-h1w9gbxk	166	58	,	,	,
cord-017764-h1w9gbxk	166	59	respectively	respectively	RB
cord-017764-h1w9gbxk	166	60	[	[	-LRB-
cord-017764-h1w9gbxk	166	61	3	3	CD
cord-017764-h1w9gbxk	166	62	]	]	-RRB-
cord-017764-h1w9gbxk	166	63	.	.	.
cord-017764-h1w9gbxk	167	1	Compound	compound	NN
cord-017764-h1w9gbxk	167	2	1	1	CD
cord-017764-h1w9gbxk	167	3	was	be	VBD
cord-017764-h1w9gbxk	167	4	quickly	quickly	RB
cord-017764-h1w9gbxk	167	5	absorbed	absorb	VBN
cord-017764-h1w9gbxk	167	6	and	and	CC
cord-017764-h1w9gbxk	167	7	exposure	exposure	NN
cord-017764-h1w9gbxk	167	8	extended	extend	VBN
cord-017764-h1w9gbxk	167	9	beyond	beyond	IN
cord-017764-h1w9gbxk	167	10	24	24	CD
cord-017764-h1w9gbxk	167	11	h	h	NN
cord-017764-h1w9gbxk	167	12	,	,	,
cord-017764-h1w9gbxk	167	13	with	with	IN
cord-017764-h1w9gbxk	167	14	plasma	plasma	NN
cord-017764-h1w9gbxk	167	15	drug	drug	NN
cord-017764-h1w9gbxk	167	16	concentration	concentration	NN
cord-017764-h1w9gbxk	167	17	maintained	maintain	VBN
cord-017764-h1w9gbxk	167	18	above	above	IN
cord-017764-h1w9gbxk	167	19	the	the	DT
cord-017764-h1w9gbxk	167	20	less	less	RBR
cord-017764-h1w9gbxk	167	21	sensitive	sensitive	JJ
cord-017764-h1w9gbxk	167	22	GT-1a	gt-1a	NN
cord-017764-h1w9gbxk	167	23	protein	protein	NN
cord-017764-h1w9gbxk	167	24	-	-	HYPH
cord-017764-h1w9gbxk	167	25	binding	bind	VBG
cord-017764-h1w9gbxk	167	26	-	-	HYPH
cord-017764-h1w9gbxk	167	27	adjusted	adjust	VBN
cord-017764-h1w9gbxk	167	28	EC	EC	NNP
cord-017764-h1w9gbxk	167	29	90	90	CD
cord-017764-h1w9gbxk	167	30	value	value	NN
cord-017764-h1w9gbxk	167	31	of	of	IN
cord-017764-h1w9gbxk	167	32	383	383	CD
cord-017764-h1w9gbxk	167	33	pM	pm	NN
cord-017764-h1w9gbxk	167	34	at	at	IN
cord-017764-h1w9gbxk	167	35	72	72	CD
cord-017764-h1w9gbxk	167	36	h	h	NN
cord-017764-h1w9gbxk	167	37	for	for	IN
cord-017764-h1w9gbxk	167	38	all	all	DT
cord-017764-h1w9gbxk	167	39	but	but	CC
cord-017764-h1w9gbxk	167	40	the	the	DT
cord-017764-h1w9gbxk	167	41	1	1	CD
cord-017764-h1w9gbxk	167	42	mg	mg	NNP
cord-017764-h1w9gbxk	167	43	dose	dose	NN
cord-017764-h1w9gbxk	167	44	,	,	,
cord-017764-h1w9gbxk	167	45	predicting	predict	VBG
cord-017764-h1w9gbxk	167	46	the	the	DT
cord-017764-h1w9gbxk	167	47	potential	potential	NN
cord-017764-h1w9gbxk	167	48	for	for	IN
cord-017764-h1w9gbxk	167	49	once	once	RB
cord-017764-h1w9gbxk	167	50	-	-	HYPH
cord-017764-h1w9gbxk	167	51	daily	daily	NN
cord-017764-h1w9gbxk	167	52	dosing	dose	VBG
cord-017764-h1w9gbxk	167	53	[	[	-LRB-
cord-017764-h1w9gbxk	167	54	51	51	CD
cord-017764-h1w9gbxk	167	55	]	]	-RRB-
cord-017764-h1w9gbxk	167	56	.	.	.
cord-017764-h1w9gbxk	168	1	The	the	DT
cord-017764-h1w9gbxk	168	2	absolute	absolute	JJ
cord-017764-h1w9gbxk	168	3	oral	oral	JJ
cord-017764-h1w9gbxk	168	4	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	168	5	of	of	IN
cord-017764-h1w9gbxk	168	6	1	1	CD
cord-017764-h1w9gbxk	168	7	in	in	IN
cord-017764-h1w9gbxk	168	8	humans	human	NNS
cord-017764-h1w9gbxk	168	9	is	be	VBZ
cord-017764-h1w9gbxk	168	10	67	67	CD
cord-017764-h1w9gbxk	168	11	%	%	NN
cord-017764-h1w9gbxk	168	12	,	,	,
cord-017764-h1w9gbxk	168	13	and	and	CC
cord-017764-h1w9gbxk	168	14	the	the	DT
cord-017764-h1w9gbxk	168	15	compound	compound	NN
cord-017764-h1w9gbxk	168	16	is~99	is~99	NNP
cord-017764-h1w9gbxk	168	17	%	%	NN
cord-017764-h1w9gbxk	168	18	bound	bind	VBN
cord-017764-h1w9gbxk	168	19	to	to	IN
cord-017764-h1w9gbxk	168	20	plasma	plasma	NN
cord-017764-h1w9gbxk	168	21	proteins	protein	NNS
cord-017764-h1w9gbxk	168	22	[	[	-LRB-
cord-017764-h1w9gbxk	168	23	77	77	CD
cord-017764-h1w9gbxk	168	24	]	]	-RRB-
cord-017764-h1w9gbxk	168	25	[	[	-LRB-
cord-017764-h1w9gbxk	168	26	78	78	CD
cord-017764-h1w9gbxk	168	27	]	]	-RRB-
cord-017764-h1w9gbxk	168	28	[	[	-LRB-
cord-017764-h1w9gbxk	168	29	79	79	CD
cord-017764-h1w9gbxk	168	30	]	]	-RRB-
cord-017764-h1w9gbxk	168	31	[	[	-LRB-
cord-017764-h1w9gbxk	168	32	80	80	CD
cord-017764-h1w9gbxk	168	33	]	]	-RRB-
cord-017764-h1w9gbxk	168	34	.	.	.
cord-017764-h1w9gbxk	169	1	In	in	IN
cord-017764-h1w9gbxk	169	2	this	this	DT
cord-017764-h1w9gbxk	169	3	trial	trial	NN
cord-017764-h1w9gbxk	169	4	,	,	,
cord-017764-h1w9gbxk	169	5	1	1	CD
cord-017764-h1w9gbxk	169	6	was	be	VBD
cord-017764-h1w9gbxk	169	7	safe	safe	JJ
cord-017764-h1w9gbxk	169	8	and	and	CC
cord-017764-h1w9gbxk	169	9	well	well	RB
cord-017764-h1w9gbxk	169	10	tolerated	tolerate	VBN
cord-017764-h1w9gbxk	169	11	at	at	IN
cord-017764-h1w9gbxk	169	12	all	all	DT
cord-017764-h1w9gbxk	169	13	of	of	IN
cord-017764-h1w9gbxk	169	14	the	the	DT
cord-017764-h1w9gbxk	169	15	administered	administer	VBN
cord-017764-h1w9gbxk	169	16	doses	dose	NNS
cord-017764-h1w9gbxk	169	17	with	with	IN
cord-017764-h1w9gbxk	169	18	no	no	DT
cord-017764-h1w9gbxk	169	19	clinically	clinically	RB
cord-017764-h1w9gbxk	169	20	significant	significant	JJ
cord-017764-h1w9gbxk	169	21	adverse	adverse	JJ
cord-017764-h1w9gbxk	169	22	effects	effect	NNS
cord-017764-h1w9gbxk	169	23	observed	observe	VBN
cord-017764-h1w9gbxk	169	24	,	,	,
cord-017764-h1w9gbxk	169	25	a	a	DT
cord-017764-h1w9gbxk	169	26	profile	profile	NN
cord-017764-h1w9gbxk	169	27	that	that	WDT
cord-017764-h1w9gbxk	169	28	set	set	VBD
cord-017764-h1w9gbxk	169	29	the	the	DT
cord-017764-h1w9gbxk	169	30	stage	stage	NN
cord-017764-h1w9gbxk	169	31	for	for	IN
cord-017764-h1w9gbxk	169	32	a	a	DT
cord-017764-h1w9gbxk	169	33	proof	proof	NN
cord-017764-h1w9gbxk	169	34	-	-	HYPH
cord-017764-h1w9gbxk	169	35	of	of	IN
cord-017764-h1w9gbxk	169	36	-	-	HYPH
cord-017764-h1w9gbxk	169	37	concept	concept	NN
cord-017764-h1w9gbxk	169	38	study	study	NN
cord-017764-h1w9gbxk	169	39	in	in	IN
cord-017764-h1w9gbxk	169	40	HCV	HCV	NNP
cord-017764-h1w9gbxk	169	41	GT-1infected	GT-1infected	NNP
cord-017764-h1w9gbxk	169	42	subjects	subject	NNS
cord-017764-h1w9gbxk	169	43	.	.	.
cord-017764-h1w9gbxk	170	1	Doses	dose	NNS
cord-017764-h1w9gbxk	170	2	of	of	IN
cord-017764-h1w9gbxk	170	3	1	1	CD
cord-017764-h1w9gbxk	170	4	,	,	,
cord-017764-h1w9gbxk	170	5	10	10	CD
cord-017764-h1w9gbxk	170	6	,	,	,
cord-017764-h1w9gbxk	170	7	and	and	CC
cord-017764-h1w9gbxk	170	8	100	100	CD
cord-017764-h1w9gbxk	170	9	mg	mg	NNS
cord-017764-h1w9gbxk	170	10	were	be	VBD
cord-017764-h1w9gbxk	170	11	administered	administer	VBN
cord-017764-h1w9gbxk	170	12	in	in	IN
cord-017764-h1w9gbxk	170	13	a	a	DT
cord-017764-h1w9gbxk	170	14	randomized	randomized	JJ
cord-017764-h1w9gbxk	170	15	,	,	,
cord-017764-h1w9gbxk	170	16	double	double	JJ
cord-017764-h1w9gbxk	170	17	-	-	HYPH
cord-017764-h1w9gbxk	170	18	blind	blind	JJ
cord-017764-h1w9gbxk	170	19	,	,	,
cord-017764-h1w9gbxk	170	20	placebo	placebo	NN
cord-017764-h1w9gbxk	170	21	-	-	HYPH
cord-017764-h1w9gbxk	170	22	controlled	control	VBN
cord-017764-h1w9gbxk	170	23	,	,	,
cord-017764-h1w9gbxk	170	24	single	single	JJ
cord-017764-h1w9gbxk	170	25	ascending	ascend	VBG
cord-017764-h1w9gbxk	170	26	dose	dose	NN
cord-017764-h1w9gbxk	170	27	format	format	NN
cord-017764-h1w9gbxk	170	28	similar	similar	JJ
cord-017764-h1w9gbxk	170	29	to	to	IN
cord-017764-h1w9gbxk	170	30	that	that	DT
cord-017764-h1w9gbxk	170	31	used	use	VBN
cord-017764-h1w9gbxk	170	32	for	for	IN
cord-017764-h1w9gbxk	170	33	the	the	DT
cord-017764-h1w9gbxk	170	34	NHV	NHV	NNP
cord-017764-h1w9gbxk	170	35	study	study	NN
cord-017764-h1w9gbxk	170	36	,	,	,
cord-017764-h1w9gbxk	170	37	and	and	CC
cord-017764-h1w9gbxk	170	38	plasma	plasma	NN
cord-017764-h1w9gbxk	170	39	HCV	HCV	NNP
cord-017764-h1w9gbxk	170	40	RNA	RNA	NNP
cord-017764-h1w9gbxk	170	41	levels	level	NNS
cord-017764-h1w9gbxk	170	42	were	be	VBD
cord-017764-h1w9gbxk	170	43	monitored	monitor	VBN
cord-017764-h1w9gbxk	170	44	until	until	IN
cord-017764-h1w9gbxk	170	45	172	172	CD
cord-017764-h1w9gbxk	170	46	h	h	NNP
cord-017764-h1w9gbxk	170	47	postdose	postdose	NN
cord-017764-h1w9gbxk	170	48	.	.	.
cord-017764-h1w9gbxk	171	1	The	the	DT
cord-017764-h1w9gbxk	171	2	results	result	NNS
cord-017764-h1w9gbxk	171	3	of	of	IN
cord-017764-h1w9gbxk	171	4	this	this	DT
cord-017764-h1w9gbxk	171	5	study	study	NN
cord-017764-h1w9gbxk	171	6	are	be	VBP
cord-017764-h1w9gbxk	171	7	compiled	compile	VBN
cord-017764-h1w9gbxk	171	8	in	in	IN
cord-017764-h1w9gbxk	171	9	Table	Table	NNP
cord-017764-h1w9gbxk	171	10	4	4	CD
cord-017764-h1w9gbxk	171	11	with	with	IN
cord-017764-h1w9gbxk	171	12	mean	mean	JJ
cord-017764-h1w9gbxk	171	13	plasma	plasma	NN
cord-017764-h1w9gbxk	171	14	HCV	HCV	NNP
cord-017764-h1w9gbxk	171	15	RNA	RNA	NNP
cord-017764-h1w9gbxk	171	16	declining	decline	VBG
cord-017764-h1w9gbxk	171	17	by	by	IN
cord-017764-h1w9gbxk	171	18	1.8	1.8	CD
cord-017764-h1w9gbxk	171	19	log	log	NN
cord-017764-h1w9gbxk	171	20	10	10	CD
cord-017764-h1w9gbxk	171	21	IU	IU	NNP
cord-017764-h1w9gbxk	171	22	/	/	SYM
cord-017764-h1w9gbxk	171	23	mL	ml	NN
cord-017764-h1w9gbxk	171	24	24	24	CD
cord-017764-h1w9gbxk	171	25	h	h	NN
cord-017764-h1w9gbxk	171	26	following	follow	VBG
cord-017764-h1w9gbxk	171	27	the	the	DT
cord-017764-h1w9gbxk	171	28	1	1	CD
cord-017764-h1w9gbxk	171	29	mg	mg	NNP
cord-017764-h1w9gbxk	171	30	dose	dose	NN
cord-017764-h1w9gbxk	171	31	,	,	,
cord-017764-h1w9gbxk	171	32	while	while	IN
cord-017764-h1w9gbxk	171	33	the	the	DT
cord-017764-h1w9gbxk	171	34	10	10	CD
cord-017764-h1w9gbxk	171	35	and	and	CC
cord-017764-h1w9gbxk	171	36	100	100	CD
cord-017764-h1w9gbxk	171	37	mg	mg	NNP
cord-017764-h1w9gbxk	171	38	doses	dose	NNS
cord-017764-h1w9gbxk	171	39	provided	provide	VBD
cord-017764-h1w9gbxk	171	40	increased	increase	VBN
cord-017764-h1w9gbxk	171	41	efficacy	efficacy	NN
cord-017764-h1w9gbxk	171	42	,	,	,
cord-017764-h1w9gbxk	171	43	with	with	IN
cord-017764-h1w9gbxk	171	44	viral	viral	JJ
cord-017764-h1w9gbxk	171	45	load	load	NN
cord-017764-h1w9gbxk	171	46	declines	decline	NNS
cord-017764-h1w9gbxk	171	47	of	of	IN
cord-017764-h1w9gbxk	171	48	3.2	3.2	CD
cord-017764-h1w9gbxk	171	49	and	and	CC
cord-017764-h1w9gbxk	171	50	3.3	3.3	CD
cord-017764-h1w9gbxk	171	51	log	log	VBP
cord-017764-h1w9gbxk	171	52	10	10	CD
cord-017764-h1w9gbxk	171	53	IU	IU	NNP
cord-017764-h1w9gbxk	171	54	/	/	SYM
cord-017764-h1w9gbxk	171	55	mL	ml	NN
cord-017764-h1w9gbxk	171	56	,	,	,
cord-017764-h1w9gbxk	171	57	respectively	respectively	RB
cord-017764-h1w9gbxk	171	58	,	,	,
cord-017764-h1w9gbxk	171	59	measured	measure	VBN
cord-017764-h1w9gbxk	171	60	at	at	IN
cord-017764-h1w9gbxk	171	61	24	24	CD
cord-017764-h1w9gbxk	171	62	h.	h.	NN
cord-017764-h1w9gbxk	172	1	The	the	DT
cord-017764-h1w9gbxk	172	2	mean	mean	JJ
cord-017764-h1w9gbxk	172	3	maximal	maximal	JJ
cord-017764-h1w9gbxk	172	4	viral	viral	JJ
cord-017764-h1w9gbxk	172	5	load	load	NN
cord-017764-h1w9gbxk	172	6	reduction	reduction	NN
cord-017764-h1w9gbxk	172	7	in	in	IN
cord-017764-h1w9gbxk	172	8	the	the	DT
cord-017764-h1w9gbxk	172	9	100	100	CD
cord-017764-h1w9gbxk	172	10	mg	mg	NNP
cord-017764-h1w9gbxk	172	11	dose	dose	NN
cord-017764-h1w9gbxk	172	12	cohort	cohort	NN
cord-017764-h1w9gbxk	172	13	was	be	VBD
cord-017764-h1w9gbxk	172	14	3.6	3.6	CD
cord-017764-h1w9gbxk	172	15	log	log	NN
cord-017764-h1w9gbxk	172	16	10	10	CD
cord-017764-h1w9gbxk	172	17	IU	IU	NNP
cord-017764-h1w9gbxk	172	18	/	/	,
cord-017764-h1w9gbxk	172	19	mL	ml	NN
cord-017764-h1w9gbxk	172	20	with	with	IN
cord-017764-h1w9gbxk	172	21	HCV	HCV	NNP
cord-017764-h1w9gbxk	172	22	RNA	RNA	NNP
cord-017764-h1w9gbxk	172	23	measured	measure	VBN
cord-017764-h1w9gbxk	172	24	at	at	IN
cord-017764-h1w9gbxk	172	25	35	35	CD
cord-017764-h1w9gbxk	172	26	IU	IU	NNP
cord-017764-h1w9gbxk	172	27	/	/	SYM
cord-017764-h1w9gbxk	172	28	mL	ml	NN
cord-017764-h1w9gbxk	172	29	in	in	IN
cord-017764-h1w9gbxk	172	30	one	one	CD
cord-017764-h1w9gbxk	172	31	of	of	IN
cord-017764-h1w9gbxk	172	32	the	the	DT
cord-017764-h1w9gbxk	172	33	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	172	34	-	-	HYPH
cord-017764-h1w9gbxk	172	35	infected	infect	VBN
cord-017764-h1w9gbxk	172	36	subjects	subject	NNS
cord-017764-h1w9gbxk	172	37	,	,	,
cord-017764-h1w9gbxk	172	38	while	while	IN
cord-017764-h1w9gbxk	172	39	plasma	plasma	NN
cord-017764-h1w9gbxk	172	40	RNA	RNA	NNP
cord-017764-h1w9gbxk	172	41	in	in	IN
cord-017764-h1w9gbxk	172	42	another	another	DT
cord-017764-h1w9gbxk	172	43	was	be	VBD
cord-017764-h1w9gbxk	172	44	below	below	IN
cord-017764-h1w9gbxk	172	45	the	the	DT
cord-017764-h1w9gbxk	172	46	The	The	NNP
cord-017764-h1w9gbxk	172	47	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	172	48	and	and	CC
cord-017764-h1w9gbxk	172	49	Development	Development	NNP
cord-017764-h1w9gbxk	172	50	of	of	IN
cord-017764-h1w9gbxk	172	51	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	172	52	:	:	:
cord-017764-h1w9gbxk	173	1	An	an	DT
cord-017764-h1w9gbxk	173	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	173	3	of	of	IN
cord-017764-h1w9gbxk	173	4	the	the	DT
cord-017764-h1w9gbxk	173	5	.	.	.
cord-017764-h1w9gbxk	173	6	.	.	.
cord-017764-h1w9gbxk	173	7	.	.	.
cord-017764-h1w9gbxk	174	1	41	41	CD
cord-017764-h1w9gbxk	174	2	lower	low	JJR
cord-017764-h1w9gbxk	174	3	limit	limit	NN
cord-017764-h1w9gbxk	174	4	of	of	IN
cord-017764-h1w9gbxk	174	5	quantification	quantification	NN
cord-017764-h1w9gbxk	174	6	(	(	-LRB-
cord-017764-h1w9gbxk	174	7	25	25	CD
cord-017764-h1w9gbxk	174	8	IU	IU	NNP
cord-017764-h1w9gbxk	174	9	/	/	SYM
cord-017764-h1w9gbxk	174	10	mL	mL	NNP
cord-017764-h1w9gbxk	174	11	)	)	-RRB-
cord-017764-h1w9gbxk	174	12	at	at	IN
cord-017764-h1w9gbxk	174	13	144	144	CD
cord-017764-h1w9gbxk	174	14	h	h	NN
cord-017764-h1w9gbxk	174	15	post	post	NN
cord-017764-h1w9gbxk	174	16	-	-	JJ
cord-017764-h1w9gbxk	174	17	dose	dose	NN
cord-017764-h1w9gbxk	174	18	.	.	.
cord-017764-h1w9gbxk	175	1	The	the	DT
cord-017764-h1w9gbxk	175	2	decline	decline	NN
cord-017764-h1w9gbxk	175	3	in	in	IN
cord-017764-h1w9gbxk	175	4	plasma	plasma	NN
cord-017764-h1w9gbxk	175	5	viral	viral	JJ
cord-017764-h1w9gbxk	175	6	RNA	RNA	NNP
cord-017764-h1w9gbxk	175	7	concentration	concentration	NN
cord-017764-h1w9gbxk	175	8	following	follow	VBG
cord-017764-h1w9gbxk	175	9	administration	administration	NN
cord-017764-h1w9gbxk	175	10	of	of	IN
cord-017764-h1w9gbxk	175	11	the	the	DT
cord-017764-h1w9gbxk	175	12	10	10	CD
cord-017764-h1w9gbxk	175	13	and	and	CC
cord-017764-h1w9gbxk	175	14	100	100	CD
cord-017764-h1w9gbxk	175	15	mg	mg	NNP
cord-017764-h1w9gbxk	175	16	doses	dose	NNS
cord-017764-h1w9gbxk	175	17	of	of	IN
cord-017764-h1w9gbxk	175	18	1	1	CD
cord-017764-h1w9gbxk	175	19	was	be	VBD
cord-017764-h1w9gbxk	175	20	both	both	DT
cord-017764-h1w9gbxk	175	21	rapid	rapid	JJ
cord-017764-h1w9gbxk	175	22	and	and	CC
cord-017764-h1w9gbxk	175	23	profound	profound	JJ
cord-017764-h1w9gbxk	175	24	in	in	IN
cord-017764-h1w9gbxk	175	25	nature	nature	NN
cord-017764-h1w9gbxk	175	26	,	,	,
cord-017764-h1w9gbxk	175	27	with	with	IN
cord-017764-h1w9gbxk	175	28	a	a	DT
cord-017764-h1w9gbxk	175	29	mean	mean	JJ
cord-017764-h1w9gbxk	175	30	reduction	reduction	NN
cord-017764-h1w9gbxk	175	31	of	of	IN
cord-017764-h1w9gbxk	175	32	1.95	1.95	CD
cord-017764-h1w9gbxk	175	33	log	log	NN
cord-017764-h1w9gbxk	175	34	10	10	CD
cord-017764-h1w9gbxk	175	35	IU	IU	NNP
cord-017764-h1w9gbxk	175	36	/	/	SYM
cord-017764-h1w9gbxk	175	37	mL	ml	NN
cord-017764-h1w9gbxk	175	38	measured	measure	VBN
cord-017764-h1w9gbxk	175	39	at	at	IN
cord-017764-h1w9gbxk	175	40	6	6	CD
cord-017764-h1w9gbxk	175	41	h	h	NN
cord-017764-h1w9gbxk	175	42	post	post	NN
cord-017764-h1w9gbxk	175	43	-	-	NN
cord-017764-h1w9gbxk	175	44	dose	dose	NN
cord-017764-h1w9gbxk	175	45	for	for	IN
cord-017764-h1w9gbxk	175	46	nine	nine	CD
cord-017764-h1w9gbxk	175	47	of	of	IN
cord-017764-h1w9gbxk	175	48	the	the	DT
cord-017764-h1w9gbxk	175	49	patients	patient	NNS
cord-017764-h1w9gbxk	175	50	[	[	-LRB-
cord-017764-h1w9gbxk	175	51	49	49	CD
cord-017764-h1w9gbxk	175	52	,	,	,
cord-017764-h1w9gbxk	175	53	51	51	CD
cord-017764-h1w9gbxk	175	54	]	]	-RRB-
cord-017764-h1w9gbxk	175	55	.	.	.
cord-017764-h1w9gbxk	176	1	The	the	DT
cord-017764-h1w9gbxk	176	2	steep	steep	JJ
cord-017764-h1w9gbxk	176	3	decline	decline	NN
cord-017764-h1w9gbxk	176	4	in	in	IN
cord-017764-h1w9gbxk	176	5	viral	viral	JJ
cord-017764-h1w9gbxk	176	6	load	load	NN
cord-017764-h1w9gbxk	176	7	was	be	VBD
cord-017764-h1w9gbxk	176	8	subsequently	subsequently	RB
cord-017764-h1w9gbxk	176	9	explained	explain	VBN
cord-017764-h1w9gbxk	176	10	after	after	IN
cord-017764-h1w9gbxk	176	11	the	the	DT
cord-017764-h1w9gbxk	176	12	development	development	NN
cord-017764-h1w9gbxk	176	13	of	of	IN
cord-017764-h1w9gbxk	176	14	a	a	DT
cord-017764-h1w9gbxk	176	15	multiscale	multiscale	JJ
cord-017764-h1w9gbxk	176	16	model	model	NN
cord-017764-h1w9gbxk	176	17	of	of	IN
cord-017764-h1w9gbxk	176	18	viral	viral	JJ
cord-017764-h1w9gbxk	176	19	kinetics	kinetic	NNS
cord-017764-h1w9gbxk	176	20	that	that	WDT
cord-017764-h1w9gbxk	176	21	took	take	VBD
cord-017764-h1w9gbxk	176	22	into	into	IN
cord-017764-h1w9gbxk	176	23	account	account	NN
cord-017764-h1w9gbxk	176	24	the	the	DT
cord-017764-h1w9gbxk	176	25	effects	effect	NNS
cord-017764-h1w9gbxk	176	26	of	of	IN
cord-017764-h1w9gbxk	176	27	1	1	CD
cord-017764-h1w9gbxk	176	28	on	on	IN
cord-017764-h1w9gbxk	176	29	both	both	DT
cord-017764-h1w9gbxk	176	30	viral	viral	JJ
cord-017764-h1w9gbxk	176	31	replication	replication	NN
cord-017764-h1w9gbxk	176	32	and	and	CC
cord-017764-h1w9gbxk	176	33	virus	virus	NN
cord-017764-h1w9gbxk	176	34	assembly	assembly	NN
cord-017764-h1w9gbxk	176	35	and	and	CC
cord-017764-h1w9gbxk	176	36	secretion	secretion	NN
cord-017764-h1w9gbxk	176	37	,	,	,
cord-017764-h1w9gbxk	176	38	with	with	IN
cord-017764-h1w9gbxk	176	39	the	the	DT
cord-017764-h1w9gbxk	176	40	latter	latter	JJ
cord-017764-h1w9gbxk	176	41	being	be	VBG
cord-017764-h1w9gbxk	176	42	the	the	DT
cord-017764-h1w9gbxk	176	43	source	source	NN
cord-017764-h1w9gbxk	176	44	of	of	IN
cord-017764-h1w9gbxk	176	45	an	an	DT
cord-017764-h1w9gbxk	176	46	immediate	immediate	JJ
cord-017764-h1w9gbxk	176	47	effect	effect	NN
cord-017764-h1w9gbxk	176	48	on	on	IN
cord-017764-h1w9gbxk	176	49	virion	virion	NN
cord-017764-h1w9gbxk	176	50	production	production	NN
cord-017764-h1w9gbxk	176	51	.	.	.
cord-017764-h1w9gbxk	177	1	The	the	DT
cord-017764-h1w9gbxk	177	2	mean	mean	JJ
cord-017764-h1w9gbxk	177	3	effectiveness	effectiveness	NN
cord-017764-h1w9gbxk	177	4	of	of	IN
cord-017764-h1w9gbxk	177	5	1	1	CD
cord-017764-h1w9gbxk	177	6	on	on	IN
cord-017764-h1w9gbxk	177	7	virus	virus	NN
cord-017764-h1w9gbxk	177	8	RNA	rna	NN
cord-017764-h1w9gbxk	177	9	production	production	NN
cord-017764-h1w9gbxk	177	10	and	and	CC
cord-017764-h1w9gbxk	177	11	virion	virion	NN
cord-017764-h1w9gbxk	177	12	assembly	assembly	NN
cord-017764-h1w9gbxk	177	13	/	/	SYM
cord-017764-h1w9gbxk	177	14	secretion	secretion	NN
cord-017764-h1w9gbxk	177	15	was	be	VBD
cord-017764-h1w9gbxk	177	16	estimated	estimate	VBN
cord-017764-h1w9gbxk	177	17	to	to	TO
cord-017764-h1w9gbxk	177	18	be	be	VB
cord-017764-h1w9gbxk	177	19	99	99	CD
cord-017764-h1w9gbxk	177	20	and	and	CC
cord-017764-h1w9gbxk	177	21	99.8	99.8	CD
cord-017764-h1w9gbxk	177	22	%	%	NN
cord-017764-h1w9gbxk	177	23	,	,	,
cord-017764-h1w9gbxk	177	24	respectively	respectively	RB
cord-017764-h1w9gbxk	177	25	,	,	,
cord-017764-h1w9gbxk	177	26	and	and	CC
cord-017764-h1w9gbxk	177	27	yielded	yield	VBD
cord-017764-h1w9gbxk	177	28	an	an	DT
cord-017764-h1w9gbxk	177	29	estimate	estimate	NN
cord-017764-h1w9gbxk	177	30	of	of	IN
cord-017764-h1w9gbxk	177	31	plasma	plasma	NN
cord-017764-h1w9gbxk	177	32	HCV	HCV	NNP
cord-017764-h1w9gbxk	177	33	half	half	JJ
cord-017764-h1w9gbxk	177	34	-	-	HYPH
cord-017764-h1w9gbxk	177	35	life	life	NN
cord-017764-h1w9gbxk	177	36	of	of	IN
cord-017764-h1w9gbxk	177	37	45	45	CD
cord-017764-h1w9gbxk	177	38	min	min	NN
cord-017764-h1w9gbxk	177	39	,	,	,
cord-017764-h1w9gbxk	177	40	significantly	significantly	RB
cord-017764-h1w9gbxk	177	41	shorter	short	JJR
cord-017764-h1w9gbxk	177	42	than	than	IN
cord-017764-h1w9gbxk	177	43	the	the	DT
cord-017764-h1w9gbxk	177	44	2.7	2.7	CD
cord-017764-h1w9gbxk	177	45	h	h	NN
cord-017764-h1w9gbxk	177	46	halflife	halflife	NN
cord-017764-h1w9gbxk	177	47	estimated	estimate	VBN
cord-017764-h1w9gbxk	177	48	from	from	IN
cord-017764-h1w9gbxk	177	49	an	an	DT
cord-017764-h1w9gbxk	177	50	analysis	analysis	NN
cord-017764-h1w9gbxk	177	51	of	of	IN
cord-017764-h1w9gbxk	177	52	viral	viral	JJ
cord-017764-h1w9gbxk	177	53	kinetics	kinetic	NNS
cord-017764-h1w9gbxk	177	54	during	during	IN
cord-017764-h1w9gbxk	177	55	treatment	treatment	NN
cord-017764-h1w9gbxk	177	56	with	with	IN
cord-017764-h1w9gbxk	177	57	older	old	JJR
cord-017764-h1w9gbxk	177	58	,	,	,
cord-017764-h1w9gbxk	177	59	interferon	interferon	NN
cord-017764-h1w9gbxk	177	60	-	-	HYPH
cord-017764-h1w9gbxk	177	61	based	base	VBN
cord-017764-h1w9gbxk	177	62	therapies	therapy	NNS
cord-017764-h1w9gbxk	177	63	[	[	-LRB-
cord-017764-h1w9gbxk	177	64	49	49	CD
cord-017764-h1w9gbxk	177	65	]	]	-RRB-
cord-017764-h1w9gbxk	177	66	.	.	.
cord-017764-h1w9gbxk	178	1	The	the	DT
cord-017764-h1w9gbxk	178	2	profile	profile	NN
cord-017764-h1w9gbxk	178	3	of	of	IN
cord-017764-h1w9gbxk	178	4	1	1	CD
cord-017764-h1w9gbxk	178	5	was	be	VBD
cord-017764-h1w9gbxk	178	6	further	further	RB
cord-017764-h1w9gbxk	178	7	explored	explore	VBN
cord-017764-h1w9gbxk	178	8	in	in	IN
cord-017764-h1w9gbxk	178	9	a	a	DT
cord-017764-h1w9gbxk	178	10	double	double	JJ
cord-017764-h1w9gbxk	178	11	-	-	HYPH
cord-017764-h1w9gbxk	178	12	blind	blind	JJ
cord-017764-h1w9gbxk	178	13	,	,	,
cord-017764-h1w9gbxk	178	14	placebo	placebo	NN
cord-017764-h1w9gbxk	178	15	-	-	HYPH
cord-017764-h1w9gbxk	178	16	controlled	control	VBN
cord-017764-h1w9gbxk	178	17	multiple	multiple	JJ
cord-017764-h1w9gbxk	178	18	ascending	ascend	VBG
cord-017764-h1w9gbxk	178	19	dose	dose	JJ
cord-017764-h1w9gbxk	178	20	study	study	NN
cord-017764-h1w9gbxk	178	21	in	in	IN
cord-017764-h1w9gbxk	178	22	which	which	WDT
cord-017764-h1w9gbxk	178	23	the	the	DT
cord-017764-h1w9gbxk	178	24	drug	drug	NN
cord-017764-h1w9gbxk	178	25	was	be	VBD
cord-017764-h1w9gbxk	178	26	administered	administer	VBN
cord-017764-h1w9gbxk	178	27	for	for	IN
cord-017764-h1w9gbxk	178	28	14	14	CD
cord-017764-h1w9gbxk	178	29	consecutive	consecutive	JJ
cord-017764-h1w9gbxk	178	30	days	day	NNS
cord-017764-h1w9gbxk	178	31	to	to	IN
cord-017764-h1w9gbxk	178	32	GT-1-infected	gt-1-infected	JJ
cord-017764-h1w9gbxk	178	33	subjects	subject	NNS
cord-017764-h1w9gbxk	178	34	at	at	IN
cord-017764-h1w9gbxk	178	35	doses	dose	NNS
cord-017764-h1w9gbxk	178	36	of	of	IN
cord-017764-h1w9gbxk	178	37	1	1	CD
cord-017764-h1w9gbxk	178	38	,	,	,
cord-017764-h1w9gbxk	178	39	10	10	CD
cord-017764-h1w9gbxk	178	40	,	,	,
cord-017764-h1w9gbxk	178	41	30	30	CD
cord-017764-h1w9gbxk	178	42	,	,	,
cord-017764-h1w9gbxk	178	43	60	60	CD
cord-017764-h1w9gbxk	178	44	,	,	,
cord-017764-h1w9gbxk	178	45	and	and	CC
cord-017764-h1w9gbxk	178	46	100	100	CD
cord-017764-h1w9gbxk	178	47	mg	mg	NNS
cord-017764-h1w9gbxk	178	48	once	once	RB
cord-017764-h1w9gbxk	178	49	daily	daily	RB
cord-017764-h1w9gbxk	178	50	and	and	CC
cord-017764-h1w9gbxk	178	51	30	30	CD
cord-017764-h1w9gbxk	178	52	mg	mg	NN
cord-017764-h1w9gbxk	178	53	twice	twice	RB
cord-017764-h1w9gbxk	178	54	daily	daily	JJ
cord-017764-h1w9gbxk	178	55	[	[	-LRB-
cord-017764-h1w9gbxk	178	56	51	51	CD
cord-017764-h1w9gbxk	178	57	]	]	-RRB-
cord-017764-h1w9gbxk	178	58	.	.	.
cord-017764-h1w9gbxk	179	1	Each	each	DT
cord-017764-h1w9gbxk	179	2	panel	panel	NN
cord-017764-h1w9gbxk	179	3	comprised	comprise	VBN
cord-017764-h1w9gbxk	179	4	of	of	IN
cord-017764-h1w9gbxk	179	5	five	five	CD
cord-017764-h1w9gbxk	179	6	patients	patient	NNS
cord-017764-h1w9gbxk	180	1	randomized	randomize	VBN
cord-017764-h1w9gbxk	180	2	such	such	PDT
cord-017764-h1w9gbxk	180	3	that	that	IN
cord-017764-h1w9gbxk	180	4	four	four	CD
cord-017764-h1w9gbxk	180	5	received	receive	VBN
cord-017764-h1w9gbxk	180	6	drug	drug	NN
cord-017764-h1w9gbxk	180	7	and	and	CC
cord-017764-h1w9gbxk	180	8	one	one	CD
cord-017764-h1w9gbxk	180	9	was	be	VBD
cord-017764-h1w9gbxk	180	10	administered	administer	VBN
cord-017764-h1w9gbxk	180	11	a	a	DT
cord-017764-h1w9gbxk	180	12	placebo	placebo	NN
cord-017764-h1w9gbxk	180	13	control	control	NN
cord-017764-h1w9gbxk	180	14	,	,	,
cord-017764-h1w9gbxk	180	15	with	with	IN
cord-017764-h1w9gbxk	180	16	drug	drug	NN
cord-017764-h1w9gbxk	180	17	PK	PK	NNP
cord-017764-h1w9gbxk	180	18	parameters	parameter	NNS
cord-017764-h1w9gbxk	180	19	determined	determine	VBN
cord-017764-h1w9gbxk	180	20	on	on	IN
cord-017764-h1w9gbxk	180	21	days	day	NNS
cord-017764-h1w9gbxk	180	22	1	1	CD
cord-017764-h1w9gbxk	180	23	and	and	CC
cord-017764-h1w9gbxk	180	24	14	14	CD
cord-017764-h1w9gbxk	180	25	.	.	.
cord-017764-h1w9gbxk	181	1	Median	median	JJ
cord-017764-h1w9gbxk	181	2	peak	peak	NN
cord-017764-h1w9gbxk	181	3	plasma	plasma	NN
cord-017764-h1w9gbxk	181	4	concentrations	concentration	NNS
cord-017764-h1w9gbxk	181	5	of	of	IN
cord-017764-h1w9gbxk	181	6	1	1	CD
cord-017764-h1w9gbxk	181	7	occurred	occur	VBD
cord-017764-h1w9gbxk	181	8	1	1	CD
cord-017764-h1w9gbxk	181	9	-	-	SYM
cord-017764-h1w9gbxk	181	10	2	2	CD
cord-017764-h1w9gbxk	181	11	h	h	NN
cord-017764-h1w9gbxk	181	12	after	after	IN
cord-017764-h1w9gbxk	181	13	dosing	dosing	NN
cord-017764-h1w9gbxk	181	14	,	,	,
cord-017764-h1w9gbxk	181	15	and	and	CC
cord-017764-h1w9gbxk	181	16	the	the	DT
cord-017764-h1w9gbxk	181	17	PK	PK	NNP
cord-017764-h1w9gbxk	181	18	profile	profile	NN
cord-017764-h1w9gbxk	181	19	was	be	VBD
cord-017764-h1w9gbxk	181	20	supportive	supportive	JJ
cord-017764-h1w9gbxk	181	21	of	of	IN
cord-017764-h1w9gbxk	181	22	once	once	RB
cord-017764-h1w9gbxk	181	23	-	-	HYPH
cord-017764-h1w9gbxk	181	24	daily	daily	NN
cord-017764-h1w9gbxk	181	25	dosing	dose	VBG
cord-017764-h1w9gbxk	181	26	with	with	IN
cord-017764-h1w9gbxk	181	27	a	a	DT
cord-017764-h1w9gbxk	181	28	mean	mean	JJ
cord-017764-h1w9gbxk	181	29	terminal	terminal	JJ
cord-017764-h1w9gbxk	181	30	half	half	JJ
cord-017764-h1w9gbxk	181	31	-	-	HYPH
cord-017764-h1w9gbxk	181	32	life	life	NN
cord-017764-h1w9gbxk	181	33	of	of	IN
cord-017764-h1w9gbxk	181	34	12	12	CD
cord-017764-h1w9gbxk	181	35	-	-	SYM
cord-017764-h1w9gbxk	181	36	15	15	CD
cord-017764-h1w9gbxk	181	37	h	h	NN
cord-017764-h1w9gbxk	181	38	and	and	CC
cord-017764-h1w9gbxk	181	39	steady	steady	JJ
cord-017764-h1w9gbxk	181	40	state	state	NN
cord-017764-h1w9gbxk	181	41	achieved	achieve	VBN
cord-017764-h1w9gbxk	181	42	after	after	IN
cord-017764-h1w9gbxk	181	43	3	3	CD
cord-017764-h1w9gbxk	181	44	-	-	SYM
cord-017764-h1w9gbxk	181	45	4	4	CD
cord-017764-h1w9gbxk	181	46	days	day	NNS
cord-017764-h1w9gbxk	181	47	of	of	IN
cord-017764-h1w9gbxk	181	48	drug	drug	NN
cord-017764-h1w9gbxk	181	49	administration	administration	NN
cord-017764-h1w9gbxk	181	50	.	.	.
cord-017764-h1w9gbxk	182	1	The	the	DT
cord-017764-h1w9gbxk	182	2	mean	mean	JJ
cord-017764-h1w9gbxk	182	3	maximal	maximal	JJ
cord-017764-h1w9gbxk	182	4	reduction	reduction	NN
cord-017764-h1w9gbxk	182	5	in	in	IN
cord-017764-h1w9gbxk	182	6	HCV	HCV	NNP
cord-017764-h1w9gbxk	182	7	RNA	RNA	NNP
cord-017764-h1w9gbxk	182	8	levels	level	NNS
cord-017764-h1w9gbxk	182	9	in	in	IN
cord-017764-h1w9gbxk	182	10	plasma	plasma	NN
cord-017764-h1w9gbxk	182	11	are	be	VBP
cord-017764-h1w9gbxk	182	12	compiled	compile	VBN
cord-017764-h1w9gbxk	182	13	in	in	IN
cord-017764-h1w9gbxk	182	14	Fig	Fig	NNP
cord-017764-h1w9gbxk	182	15	.	.	.
cord-017764-h1w9gbxk	183	1	3	3	LS
cord-017764-h1w9gbxk	184	1	with	with	IN
cord-017764-h1w9gbxk	184	2	30	30	CD
cord-017764-h1w9gbxk	184	3	and	and	CC
cord-017764-h1w9gbxk	184	4	60	60	CD
cord-017764-h1w9gbxk	184	5	mg	mg	NN
cord-017764-h1w9gbxk	184	6	QD	QD	NNP
cord-017764-h1w9gbxk	184	7	cohorts	cohort	NNS
cord-017764-h1w9gbxk	184	8	comprised	comprise	VBN
cord-017764-h1w9gbxk	184	9	solely	solely	RB
cord-017764-h1w9gbxk	184	10	of	of	IN
cord-017764-h1w9gbxk	184	11	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	184	12	-	-	HYPH
cord-017764-h1w9gbxk	184	13	infected	infect	VBN
cord-017764-h1w9gbxk	184	14	subjects	subject	NNS
cord-017764-h1w9gbxk	184	15	.	.	.
cord-017764-h1w9gbxk	185	1	In	in	IN
cord-017764-h1w9gbxk	185	2	the	the	DT
cord-017764-h1w9gbxk	185	3	other	other	JJ
cord-017764-h1w9gbxk	185	4	dosing	dose	VBG
cord-017764-h1w9gbxk	185	5	cohorts	cohort	NNS
cord-017764-h1w9gbxk	185	6	,	,	,
cord-017764-h1w9gbxk	185	7	those	those	DT
cord-017764-h1w9gbxk	185	8	infected	infect	VBN
cord-017764-h1w9gbxk	185	9	with	with	IN
cord-017764-h1w9gbxk	185	10	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	185	11	virus	virus	NN
cord-017764-h1w9gbxk	185	12	exhibited	exhibit	VBD
cord-017764-h1w9gbxk	185	13	a	a	DT
cord-017764-h1w9gbxk	185	14	greater	great	JJR
cord-017764-h1w9gbxk	185	15	response	response	NN
cord-017764-h1w9gbxk	185	16	compared	compare	VBN
cord-017764-h1w9gbxk	185	17	to	to	IN
cord-017764-h1w9gbxk	185	18	those	those	DT
cord-017764-h1w9gbxk	185	19	infected	infect	VBN
cord-017764-h1w9gbxk	185	20	with	with	IN
cord-017764-h1w9gbxk	185	21	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	185	22	virus	virus	NN
cord-017764-h1w9gbxk	185	23	.	.	.
cord-017764-h1w9gbxk	186	1	However	however	RB
cord-017764-h1w9gbxk	186	2	,	,	,
cord-017764-h1w9gbxk	186	3	most	most	JJS
cord-017764-h1w9gbxk	186	4	patients	patient	NNS
cord-017764-h1w9gbxk	186	5	experienced	experience	VBD
cord-017764-h1w9gbxk	186	6	viral	viral	JJ
cord-017764-h1w9gbxk	186	7	rebound	rebound	NN
cord-017764-h1w9gbxk	186	8	on	on	IN
cord-017764-h1w9gbxk	186	9	or	or	CC
cord-017764-h1w9gbxk	186	10	before	before	IN
cord-017764-h1w9gbxk	186	11	day	day	NN
cord-017764-h1w9gbxk	186	12	7	7	CD
cord-017764-h1w9gbxk	186	13	of	of	IN
cord-017764-h1w9gbxk	186	14	therapy	therapy	NN
cord-017764-h1w9gbxk	186	15	with	with	IN
cord-017764-h1w9gbxk	186	16	viral	viral	JJ
cord-017764-h1w9gbxk	186	17	RNA	RNA	NNP
cord-017764-h1w9gbxk	186	18	levels	level	NNS
cord-017764-h1w9gbxk	186	19	below	below	IN
cord-017764-h1w9gbxk	186	20	the	the	DT
cord-017764-h1w9gbxk	186	21	mean	mean	JJ
cord-017764-h1w9gbxk	186	22	maximal	maximal	JJ
cord-017764-h1w9gbxk	186	23	decline	decline	NN
cord-017764-h1w9gbxk	186	24	except	except	IN
cord-017764-h1w9gbxk	186	25	in	in	IN
cord-017764-h1w9gbxk	186	26	the	the	DT
cord-017764-h1w9gbxk	186	27	30	30	CD
cord-017764-h1w9gbxk	186	28	mg	mg	NNP
cord-017764-h1w9gbxk	186	29	BID	BID	NNP
cord-017764-h1w9gbxk	186	30	cohort	cohort	NN
cord-017764-h1w9gbxk	186	31	(	(	-LRB-
cord-017764-h1w9gbxk	186	32	Fig	Fig	NNP
cord-017764-h1w9gbxk	186	33	.	.	.
cord-017764-h1w9gbxk	186	34	4	4	CD
cord-017764-h1w9gbxk	186	35	)	)	-RRB-
cord-017764-h1w9gbxk	186	36	.	.	.
cord-017764-h1w9gbxk	187	1	Rebound	rebound	NN
cord-017764-h1w9gbxk	187	2	was	be	VBD
cord-017764-h1w9gbxk	187	3	typically	typically	RB
cord-017764-h1w9gbxk	187	4	more	more	RBR
cord-017764-h1w9gbxk	187	5	rapid	rapid	JJ
cord-017764-h1w9gbxk	187	6	in	in	IN
cord-017764-h1w9gbxk	187	7	the	the	DT
cord-017764-h1w9gbxk	187	8	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	187	9	-	-	HYPH
cord-017764-h1w9gbxk	187	10	infected	infect	VBN
cord-017764-h1w9gbxk	187	11	subjects	subject	NNS
cord-017764-h1w9gbxk	187	12	which	which	WDT
cord-017764-h1w9gbxk	187	13	can	can	MD
cord-017764-h1w9gbxk	187	14	be	be	VB
cord-017764-h1w9gbxk	187	15	explained	explain	VBN
cord-017764-h1w9gbxk	187	16	by	by	IN
cord-017764-h1w9gbxk	187	17	a	a	DT
cord-017764-h1w9gbxk	187	18	lower	low	JJR
cord-017764-h1w9gbxk	187	19	genetic	genetic	JJ
cord-017764-h1w9gbxk	187	20	barrier	barrier	NN
cord-017764-h1w9gbxk	187	21	to	to	IN
cord-017764-h1w9gbxk	187	22	resistance	resistance	NN
cord-017764-h1w9gbxk	187	23	in	in	IN
cord-017764-h1w9gbxk	187	24	this	this	DT
cord-017764-h1w9gbxk	187	25	subtype	subtype	NN
cord-017764-h1w9gbxk	187	26	[	[	-LRB-
cord-017764-h1w9gbxk	187	27	81	81	CD
cord-017764-h1w9gbxk	187	28	]	]	-RRB-
cord-017764-h1w9gbxk	187	29	[	[	-LRB-
cord-017764-h1w9gbxk	187	30	82	82	CD
cord-017764-h1w9gbxk	187	31	]	]	-RRB-
cord-017764-h1w9gbxk	187	32	[	[	-LRB-
cord-017764-h1w9gbxk	187	33	83	83	CD
cord-017764-h1w9gbxk	187	34	]	]	-RRB-
cord-017764-h1w9gbxk	187	35	.	.	.
cord-017764-h1w9gbxk	188	1	In	in	IN
cord-017764-h1w9gbxk	188	2	HCV	HCV	NNP
cord-017764-h1w9gbxk	188	3	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	188	4	,	,	,
cord-017764-h1w9gbxk	188	5	only	only	RB
cord-017764-h1w9gbxk	188	6	a	a	DT
cord-017764-h1w9gbxk	188	7	single	single	JJ
cord-017764-h1w9gbxk	188	8	base	base	NN
cord-017764-h1w9gbxk	188	9	pair	pair	NN
cord-017764-h1w9gbxk	188	10	change	change	NN
cord-017764-h1w9gbxk	188	11	in	in	IN
cord-017764-h1w9gbxk	188	12	the	the	DT
cord-017764-h1w9gbxk	188	13	viral	viral	JJ
cord-017764-h1w9gbxk	188	14	RNA	RNA	NNP
cord-017764-h1w9gbxk	188	15	is	be	VBZ
cord-017764-h1w9gbxk	188	16	typically	typically	RB
cord-017764-h1w9gbxk	188	17	required	require	VBN
cord-017764-h1w9gbxk	188	18	to	to	TO
cord-017764-h1w9gbxk	188	19	code	code	VB
cord-017764-h1w9gbxk	188	20	for	for	IN
cord-017764-h1w9gbxk	188	21	an	an	DT
cord-017764-h1w9gbxk	188	22	alternative	alternative	JJ
cord-017764-h1w9gbxk	188	23	amino	amino	NN
cord-017764-h1w9gbxk	188	24	acid	acid	NN
cord-017764-h1w9gbxk	188	25	,	,	,
cord-017764-h1w9gbxk	188	26	while	while	IN
cord-017764-h1w9gbxk	188	27	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	188	28	frequently	frequently	RB
cord-017764-h1w9gbxk	188	29	requires	require	VBZ
cord-017764-h1w9gbxk	188	30	two	two	CD
cord-017764-h1w9gbxk	188	31	base	base	NN
cord-017764-h1w9gbxk	188	32	pair	pair	NN
cord-017764-h1w9gbxk	188	33	changes	change	NNS
cord-017764-h1w9gbxk	188	34	for	for	IN
cord-017764-h1w9gbxk	188	35	coherent	coherent	JJ
cord-017764-h1w9gbxk	188	36	coding	coding	NN
cord-017764-h1w9gbxk	188	37	[	[	-LRB-
cord-017764-h1w9gbxk	188	38	81	81	CD
cord-017764-h1w9gbxk	188	39	]	]	-RRB-
cord-017764-h1w9gbxk	188	40	[	[	-LRB-
cord-017764-h1w9gbxk	188	41	82	82	CD
cord-017764-h1w9gbxk	188	42	]	]	-RRB-
cord-017764-h1w9gbxk	188	43	[	[	-LRB-
cord-017764-h1w9gbxk	188	44	83	83	CD
cord-017764-h1w9gbxk	188	45	]	]	-RRB-
cord-017764-h1w9gbxk	188	46	.	.	.
cord-017764-h1w9gbxk	189	1	Population	population	NN
cord-017764-h1w9gbxk	189	2	sequencing	sequencing	NN
cord-017764-h1w9gbxk	189	3	indicated	indicate	VBD
cord-017764-h1w9gbxk	189	4	the	the	DT
cord-017764-h1w9gbxk	189	5	appearance	appearance	NN
cord-017764-h1w9gbxk	189	6	of	of	IN
cord-017764-h1w9gbxk	189	7	mutations	mutation	NNS
cord-017764-h1w9gbxk	189	8	at	at	IN
cord-017764-h1w9gbxk	189	9	Met28	Met28	NNP
cord-017764-h1w9gbxk	189	10	,	,	,
cord-017764-h1w9gbxk	189	11	Gln30	Gln30	NNP
cord-017764-h1w9gbxk	189	12	,	,	,
cord-017764-h1w9gbxk	189	13	Leu31	Leu31	NNP
cord-017764-h1w9gbxk	189	14	,	,	,
cord-017764-h1w9gbxk	189	15	and	and	CC
cord-017764-h1w9gbxk	189	16	Tyr93	Tyr93	NNP
cord-017764-h1w9gbxk	189	17	all	all	DT
cord-017764-h1w9gbxk	189	18	of	of	IN
cord-017764-h1w9gbxk	189	19	which	which	WDT
cord-017764-h1w9gbxk	189	20	had	have	VBD
cord-017764-h1w9gbxk	189	21	been	be	VBN
cord-017764-h1w9gbxk	189	22	identified	identify	VBN
cord-017764-h1w9gbxk	189	23	as	as	IN
cord-017764-h1w9gbxk	189	24	resistance	resistance	NN
cord-017764-h1w9gbxk	189	25	mutation	mutation	NN
cord-017764-h1w9gbxk	189	26	hotspots	hotspot	NNS
cord-017764-h1w9gbxk	189	27	in	in	IN
cord-017764-h1w9gbxk	189	28	response	response	NN
cord-017764-h1w9gbxk	189	29	to	to	IN
cord-017764-h1w9gbxk	189	30	selective	selective	JJ
cord-017764-h1w9gbxk	189	31	pressure	pressure	NN
cord-017764-h1w9gbxk	189	32	by	by	IN
cord-017764-h1w9gbxk	189	33	1	1	CD
cord-017764-h1w9gbxk	189	34	in	in	IN
cord-017764-h1w9gbxk	189	35	replicon	replicon	NNP
cord-017764-h1w9gbxk	189	36	studies	study	NNS
cord-017764-h1w9gbxk	189	37	in	in	IN
cord-017764-h1w9gbxk	189	38	vitro	vitro	FW
cord-017764-h1w9gbxk	189	39	[	[	-LRB-
cord-017764-h1w9gbxk	189	40	84	84	CD
cord-017764-h1w9gbxk	189	41	,	,	,
cord-017764-h1w9gbxk	189	42	85	85	CD
cord-017764-h1w9gbxk	189	43	]	]	-RRB-
cord-017764-h1w9gbxk	189	44	.	.	.
cord-017764-h1w9gbxk	190	1	While	while	IN
cord-017764-h1w9gbxk	190	2	the	the	DT
cord-017764-h1w9gbxk	190	3	results	result	NNS
cord-017764-h1w9gbxk	190	4	of	of	IN
cord-017764-h1w9gbxk	190	5	this	this	DT
cord-017764-h1w9gbxk	190	6	trial	trial	NN
cord-017764-h1w9gbxk	190	7	further	further	RB
cord-017764-h1w9gbxk	190	8	confirmed	confirm	VBD
cord-017764-h1w9gbxk	190	9	the	the	DT
cord-017764-h1w9gbxk	190	10	potential	potential	NN
cord-017764-h1w9gbxk	190	11	of	of	IN
cord-017764-h1w9gbxk	190	12	HCV	HCV	NNP
cord-017764-h1w9gbxk	190	13	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	190	14	as	as	IN
cord-017764-h1w9gbxk	190	15	a	a	DT
cord-017764-h1w9gbxk	190	16	therapeutic	therapeutic	JJ
cord-017764-h1w9gbxk	190	17	target	target	NN
cord-017764-h1w9gbxk	190	18	,	,	,
cord-017764-h1w9gbxk	190	19	the	the	DT
cord-017764-h1w9gbxk	190	20	rapid	rapid	JJ
cord-017764-h1w9gbxk	190	21	emergence	emergence	NN
cord-017764-h1w9gbxk	190	22	of	of	IN
cord-017764-h1w9gbxk	190	23	resistance	resistance	NN
cord-017764-h1w9gbxk	190	24	to	to	IN
cord-017764-h1w9gbxk	190	25	1	1	CD
cord-017764-h1w9gbxk	190	26	anticipated	anticipate	VBD
cord-017764-h1w9gbxk	190	27	that	that	IN
cord-017764-h1w9gbxk	190	28	optimal	optimal	JJ
cord-017764-h1w9gbxk	190	29	clinical	clinical	JJ
cord-017764-h1w9gbxk	190	30	application	application	NN
cord-017764-h1w9gbxk	190	31	would	would	MD
cord-017764-h1w9gbxk	190	32	be	be	VB
cord-017764-h1w9gbxk	190	33	as	as	IN
cord-017764-h1w9gbxk	190	34	part	part	NN
cord-017764-h1w9gbxk	190	35	of	of	IN
cord-017764-h1w9gbxk	190	36	combination	combination	NN
cord-017764-h1w9gbxk	190	37	therapy	therapy	NN
cord-017764-h1w9gbxk	190	38	[	[	-LRB-
cord-017764-h1w9gbxk	190	39	79	79	CD
cord-017764-h1w9gbxk	190	40	,	,	,
cord-017764-h1w9gbxk	190	41	[	[	-LRB-
cord-017764-h1w9gbxk	190	42	81	81	CD
cord-017764-h1w9gbxk	190	43	]	]	-RRB-
cord-017764-h1w9gbxk	190	44	[	[	-LRB-
cord-017764-h1w9gbxk	190	45	82	82	CD
cord-017764-h1w9gbxk	190	46	]	]	-RRB-
cord-017764-h1w9gbxk	190	47	[	[	-LRB-
cord-017764-h1w9gbxk	190	48	83	83	CD
cord-017764-h1w9gbxk	190	49	]	]	-RRB-
cord-017764-h1w9gbxk	190	50	[	[	-LRB-
cord-017764-h1w9gbxk	190	51	84	84	CD
cord-017764-h1w9gbxk	190	52	]	]	-RRB-
cord-017764-h1w9gbxk	190	53	[	[	-LRB-
cord-017764-h1w9gbxk	190	54	85	85	CD
cord-017764-h1w9gbxk	190	55	]	]	-RRB-
cord-017764-h1w9gbxk	190	56	[	[	-LRB-
cord-017764-h1w9gbxk	190	57	86	86	CD
cord-017764-h1w9gbxk	190	58	]	]	-RRB-
cord-017764-h1w9gbxk	190	59	[	[	-LRB-
cord-017764-h1w9gbxk	190	60	87	87	CD
cord-017764-h1w9gbxk	190	61	]	]	-RRB-
cord-017764-h1w9gbxk	190	62	[	[	-LRB-
cord-017764-h1w9gbxk	190	63	88	88	CD
cord-017764-h1w9gbxk	190	64	]	]	-RRB-
cord-017764-h1w9gbxk	190	65	[	[	-LRB-
cord-017764-h1w9gbxk	190	66	89	89	CD
cord-017764-h1w9gbxk	190	67	]	]	-RRB-
cord-017764-h1w9gbxk	190	68	[	[	-LRB-
cord-017764-h1w9gbxk	190	69	90	90	CD
cord-017764-h1w9gbxk	190	70	]	]	-RRB-
cord-017764-h1w9gbxk	190	71	[	[	-LRB-
cord-017764-h1w9gbxk	190	72	91	91	CD
cord-017764-h1w9gbxk	190	73	]	]	-RRB-
cord-017764-h1w9gbxk	190	74	.	.	.
cord-017764-h1w9gbxk	191	1	The	the	DT
cord-017764-h1w9gbxk	191	2	combination	combination	NN
cord-017764-h1w9gbxk	191	3	of	of	IN
cord-017764-h1w9gbxk	191	4	1	1	CD
cord-017764-h1w9gbxk	191	5	as	as	IN
cord-017764-h1w9gbxk	191	6	add	add	NN
cord-017764-h1w9gbxk	191	7	-	-	HYPH
cord-017764-h1w9gbxk	191	8	on	on	RP
cord-017764-h1w9gbxk	191	9	therapy	therapy	NN
cord-017764-h1w9gbxk	191	10	to	to	IN
cord-017764-h1w9gbxk	191	11	the	the	DT
cord-017764-h1w9gbxk	191	12	extant	extant	JJ
cord-017764-h1w9gbxk	191	13	standard	standard	NN
cord-017764-h1w9gbxk	191	14	of	of	IN
cord-017764-h1w9gbxk	191	15	care	care	NN
cord-017764-h1w9gbxk	191	16	,	,	,
cord-017764-h1w9gbxk	191	17	pegylated	pegylated	JJ
cord-017764-h1w9gbxk	191	18	IFNα	IFNα	NNS
cord-017764-h1w9gbxk	191	19	and	and	CC
cord-017764-h1w9gbxk	191	20	ribavirin	ribavirin	NN
cord-017764-h1w9gbxk	191	21	(	(	-LRB-
cord-017764-h1w9gbxk	191	22	53	53	CD
cord-017764-h1w9gbxk	191	23	)	)	-RRB-
cord-017764-h1w9gbxk	191	24	,	,	,
cord-017764-h1w9gbxk	191	25	was	be	VBD
cord-017764-h1w9gbxk	191	26	explored	explore	VBN
cord-017764-h1w9gbxk	191	27	clinically	clinically	RB
cord-017764-h1w9gbxk	191	28	in	in	IN
cord-017764-h1w9gbxk	191	29	patients	patient	NNS
cord-017764-h1w9gbxk	191	30	infected	infect	VBN
cord-017764-h1w9gbxk	191	31	with	with	IN
cord-017764-h1w9gbxk	191	32	HCV	HCV	NNP
cord-017764-h1w9gbxk	191	33	genotypes	genotype	NNS
cord-017764-h1w9gbxk	191	34	1	1	CD
cord-017764-h1w9gbxk	191	35	-	-	SYM
cord-017764-h1w9gbxk	191	36	4	4	CD
cord-017764-h1w9gbxk	191	37	and	and	CC
cord-017764-h1w9gbxk	191	38	a	a	DT
cord-017764-h1w9gbxk	191	39	subset	subset	NN
cord-017764-h1w9gbxk	191	40	of	of	IN
cord-017764-h1w9gbxk	191	41	patients	patient	NNS
cord-017764-h1w9gbxk	191	42	who	who	WP
cord-017764-h1w9gbxk	191	43	were	be	VBD
cord-017764-h1w9gbxk	191	44	co	co	JJ
cord-017764-h1w9gbxk	191	45	-	-	VBN
cord-017764-h1w9gbxk	191	46	infected	infect	VBN
cord-017764-h1w9gbxk	191	47	with	with	IN
cord-017764-h1w9gbxk	191	48	HIV-1	HIV-1	NNP
cord-017764-h1w9gbxk	191	49	.	.	.
cord-017764-h1w9gbxk	192	1	The	the	DT
cord-017764-h1w9gbxk	192	2	results	result	NNS
cord-017764-h1w9gbxk	192	3	indicated	indicate	VBD
cord-017764-h1w9gbxk	192	4	that	that	IN
cord-017764-h1w9gbxk	192	5	sustained	sustain	VBD
cord-017764-h1w9gbxk	192	6	virologic	virologic	JJ
cord-017764-h1w9gbxk	192	7	responses	response	NNS
cord-017764-h1w9gbxk	192	8	could	could	MD
cord-017764-h1w9gbxk	192	9	be	be	VB
cord-017764-h1w9gbxk	192	10	achieved	achieve	VBN
cord-017764-h1w9gbxk	192	11	with	with	IN
cord-017764-h1w9gbxk	192	12	shorter	short	JJR
cord-017764-h1w9gbxk	192	13	24-week	24-week	JJ
cord-017764-h1w9gbxk	192	14	durations	duration	NNS
cord-017764-h1w9gbxk	192	15	of	of	IN
cord-017764-h1w9gbxk	192	16	therapy	therapy	NN
cord-017764-h1w9gbxk	192	17	with	with	IN
cord-017764-h1w9gbxk	192	18	a	a	DT
cord-017764-h1w9gbxk	192	19	burden	burden	NN
cord-017764-h1w9gbxk	192	20	of	of	IN
cord-017764-h1w9gbxk	192	21	side	side	NN
cord-017764-h1w9gbxk	192	22	effects	effect	NNS
cord-017764-h1w9gbxk	192	23	comparable	comparable	JJ
cord-017764-h1w9gbxk	192	24	to	to	IN
cord-017764-h1w9gbxk	192	25	that	that	DT
cord-017764-h1w9gbxk	192	26	of	of	IN
cord-017764-h1w9gbxk	192	27	pegylated	pegylated	JJ
cord-017764-h1w9gbxk	192	28	IFNα	IFNα	NNS
cord-017764-h1w9gbxk	192	29	and	and	CC
cord-017764-h1w9gbxk	192	30	53	53	CD
cord-017764-h1w9gbxk	192	31	[	[	-LRB-
cord-017764-h1w9gbxk	192	32	92	92	CD
cord-017764-h1w9gbxk	192	33	]	]	-RRB-
cord-017764-h1w9gbxk	193	1	[	[	-LRB-
cord-017764-h1w9gbxk	193	2	93	93	CD
cord-017764-h1w9gbxk	193	3	]	]	-RRB-
cord-017764-h1w9gbxk	194	1	[	[	-LRB-
cord-017764-h1w9gbxk	194	2	94	94	CD
cord-017764-h1w9gbxk	194	3	]	]	-RRB-
cord-017764-h1w9gbxk	194	4	[	[	-LRB-
cord-017764-h1w9gbxk	194	5	95	95	CD
cord-017764-h1w9gbxk	194	6	]	]	-RRB-
cord-017764-h1w9gbxk	195	1	[	[	-LRB-
cord-017764-h1w9gbxk	195	2	96	96	CD
cord-017764-h1w9gbxk	195	3	]	]	-RRB-
cord-017764-h1w9gbxk	195	4	.	.	.
cord-017764-h1w9gbxk	196	1	However	however	RB
cord-017764-h1w9gbxk	196	2	,	,	,
cord-017764-h1w9gbxk	196	3	it	-PRON-	PRP
cord-017764-h1w9gbxk	196	4	was	be	VBD
cord-017764-h1w9gbxk	196	5	the	the	DT
cord-017764-h1w9gbxk	196	6	opportunity	opportunity	NN
cord-017764-h1w9gbxk	196	7	availed	avail	VBN
cord-017764-h1w9gbxk	196	8	by	by	IN
cord-017764-h1w9gbxk	196	9	the	the	DT
cord-017764-h1w9gbxk	196	10	contemporaneous	contemporaneous	JJ
cord-017764-h1w9gbxk	196	11	development	development	NN
cord-017764-h1w9gbxk	196	12	of	of	IN
cord-017764-h1w9gbxk	196	13	the	the	DT
cord-017764-h1w9gbxk	196	14	HCV	HCV	NNP
cord-017764-h1w9gbxk	196	15	NS3	NS3	NNP
cord-017764-h1w9gbxk	196	16	protease	protease	NN
cord-017764-h1w9gbxk	196	17	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	196	18	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	196	19	(	(	-LRB-
cord-017764-h1w9gbxk	196	20	54	54	CD
cord-017764-h1w9gbxk	196	21	)	)	-RRB-
cord-017764-h1w9gbxk	196	22	that	that	WDT
cord-017764-h1w9gbxk	196	23	allowed	allow	VBD
cord-017764-h1w9gbxk	196	24	the	the	DT
cord-017764-h1w9gbxk	196	25	pursuit	pursuit	NN
cord-017764-h1w9gbxk	196	26	of	of	IN
cord-017764-h1w9gbxk	196	27	a	a	DT
cord-017764-h1w9gbxk	196	28	parallel	parallel	JJ
cord-017764-h1w9gbxk	196	29	clinical	clinical	JJ
cord-017764-h1w9gbxk	196	30	program	program	NN
cord-017764-h1w9gbxk	196	31	that	that	WDT
cord-017764-h1w9gbxk	196	32	had	have	VBD
cord-017764-h1w9gbxk	196	33	a	a	DT
cord-017764-h1w9gbxk	196	34	significant	significant	JJ
cord-017764-h1w9gbxk	196	35	impact	impact	NN
cord-017764-h1w9gbxk	196	36	on	on	IN
cord-017764-h1w9gbxk	196	37	the	the	DT
cord-017764-h1w9gbxk	196	38	course	course	NN
cord-017764-h1w9gbxk	196	39	of	of	IN
cord-017764-h1w9gbxk	196	40	the	the	DT
cord-017764-h1w9gbxk	196	41	clinical	clinical	JJ
cord-017764-h1w9gbxk	196	42	development	development	NN
cord-017764-h1w9gbxk	196	43	of	of	IN
cord-017764-h1w9gbxk	196	44	HCV	HCV	NNP
cord-017764-h1w9gbxk	196	45	therapeutic	therapeutic	JJ
cord-017764-h1w9gbxk	196	46	agents	agent	NNS
cord-017764-h1w9gbxk	196	47	[	[	-LRB-
cord-017764-h1w9gbxk	196	48	97	97	CD
cord-017764-h1w9gbxk	196	49	]	]	-RRB-
cord-017764-h1w9gbxk	196	50	[	[	-LRB-
cord-017764-h1w9gbxk	196	51	98	98	CD
cord-017764-h1w9gbxk	196	52	]	]	-RRB-
cord-017764-h1w9gbxk	196	53	[	[	-LRB-
cord-017764-h1w9gbxk	196	54	99	99	CD
cord-017764-h1w9gbxk	196	55	]	]	-RRB-
cord-017764-h1w9gbxk	196	56	[	[	-LRB-
cord-017764-h1w9gbxk	196	57	100	100	CD
cord-017764-h1w9gbxk	196	58	]	]	-RRB-
cord-017764-h1w9gbxk	196	59	[	[	-LRB-
cord-017764-h1w9gbxk	196	60	101	101	CD
cord-017764-h1w9gbxk	196	61	]	]	-RRB-
cord-017764-h1w9gbxk	196	62	[	[	-LRB-
cord-017764-h1w9gbxk	196	63	102	102	CD
cord-017764-h1w9gbxk	196	64	]	]	-RRB-
cord-017764-h1w9gbxk	196	65	.	.	.
cord-017764-h1w9gbxk	197	1	In	in	IN
cord-017764-h1w9gbxk	197	2	a	a	DT
cord-017764-h1w9gbxk	197	3	small	small	JJ
cord-017764-h1w9gbxk	197	4	open	open	JJ
cord-017764-h1w9gbxk	197	5	-	-	HYPH
cord-017764-h1w9gbxk	197	6	label	label	NN
cord-017764-h1w9gbxk	197	7	clinical	clinical	JJ
cord-017764-h1w9gbxk	197	8	trial	trial	NN
cord-017764-h1w9gbxk	197	9	conducted	conduct	VBN
cord-017764-h1w9gbxk	197	10	in	in	IN
cord-017764-h1w9gbxk	197	11	HCV	HCV	NNP
cord-017764-h1w9gbxk	197	12	GT-1-infected	gt-1-infected	CD
cord-017764-h1w9gbxk	197	13	subjects	subject	NNS
cord-017764-h1w9gbxk	197	14	who	who	WP
cord-017764-h1w9gbxk	197	15	had	have	VBD
cord-017764-h1w9gbxk	197	16	no	no	DT
cord-017764-h1w9gbxk	197	17	evidence	evidence	NN
cord-017764-h1w9gbxk	197	18	of	of	IN
cord-017764-h1w9gbxk	197	19	cirrhosis	cirrhosis	NN
cord-017764-h1w9gbxk	197	20	and	and	CC
cord-017764-h1w9gbxk	197	21	who	who	WP
cord-017764-h1w9gbxk	197	22	had	have	VBD
cord-017764-h1w9gbxk	197	23	previously	previously	RB
cord-017764-h1w9gbxk	197	24	failed	fail	VBN
cord-017764-h1w9gbxk	197	25	to	to	TO
cord-017764-h1w9gbxk	197	26	respond	respond	VB
cord-017764-h1w9gbxk	197	27	to	to	IN
cord-017764-h1w9gbxk	197	28	peg	peg	NN
cord-017764-h1w9gbxk	197	29	-	-	HYPH
cord-017764-h1w9gbxk	197	30	IFN/53	ifn/53	NN
cord-017764-h1w9gbxk	197	31	therapy	therapy	NN
cord-017764-h1w9gbxk	197	32	(	(	-LRB-
cord-017764-h1w9gbxk	197	33	referred	refer	VBN
cord-017764-h1w9gbxk	197	34	to	to	IN
cord-017764-h1w9gbxk	197	35	as	as	IN
cord-017764-h1w9gbxk	197	36	null	null	JJ
cord-017764-h1w9gbxk	197	37	responders	responder	NNS
cord-017764-h1w9gbxk	197	38	)	)	-RRB-
cord-017764-h1w9gbxk	197	39	,	,	,
cord-017764-h1w9gbxk	197	40	a	a	DT
cord-017764-h1w9gbxk	197	41	combination	combination	NN
cord-017764-h1w9gbxk	197	42	of	of	IN
cord-017764-h1w9gbxk	197	43	1	1	CD
cord-017764-h1w9gbxk	197	44	(	(	-LRB-
cord-017764-h1w9gbxk	197	45	60	60	CD
cord-017764-h1w9gbxk	197	46	mg	mg	NN
cord-017764-h1w9gbxk	197	47	QD	QD	NNP
cord-017764-h1w9gbxk	197	48	PO	PO	NNP
cord-017764-h1w9gbxk	197	49	)	)	-RRB-
cord-017764-h1w9gbxk	197	50	and	and	CC
cord-017764-h1w9gbxk	197	51	54	54	CD
cord-017764-h1w9gbxk	197	52	(	(	-LRB-
cord-017764-h1w9gbxk	197	53	600	600	CD
cord-017764-h1w9gbxk	197	54	mg	mg	NN
cord-017764-h1w9gbxk	197	55	BID	BID	NNP
cord-017764-h1w9gbxk	197	56	PO	PO	NNP
cord-017764-h1w9gbxk	197	57	)	)	-RRB-
cord-017764-h1w9gbxk	197	58	with	with	IN
cord-017764-h1w9gbxk	197	59	peg	peg	NN
cord-017764-h1w9gbxk	197	60	-	-	HYPH
cord-017764-h1w9gbxk	197	61	interferon	interferon	NN
cord-017764-h1w9gbxk	197	62	α2a	α2a	''
cord-017764-h1w9gbxk	197	63	(	(	-LRB-
cord-017764-h1w9gbxk	197	64	180	180	CD
cord-017764-h1w9gbxk	197	65	μg	μg	NN
cord-017764-h1w9gbxk	197	66	per	per	IN
cord-017764-h1w9gbxk	197	67	week	week	NN
cord-017764-h1w9gbxk	197	68	subcutaneously	subcutaneously	RB
cord-017764-h1w9gbxk	197	69	)	)	-RRB-
cord-017764-h1w9gbxk	197	70	and	and	CC
cord-017764-h1w9gbxk	197	71	53	53	CD
cord-017764-h1w9gbxk	197	72	(	(	-LRB-
cord-017764-h1w9gbxk	197	73	1,000	1,000	CD
cord-017764-h1w9gbxk	197	74	or	or	CC
cord-017764-h1w9gbxk	197	75	1,200	1,200	CD
cord-017764-h1w9gbxk	197	76	mg	mg	NNP
cord-017764-h1w9gbxk	197	77	QD	QD	NNP
cord-017764-h1w9gbxk	197	78	PO	PO	NNP
cord-017764-h1w9gbxk	197	79	,	,	,
cord-017764-h1w9gbxk	197	80	depending	depend	VBG
cord-017764-h1w9gbxk	197	81	on	on	IN
cord-017764-h1w9gbxk	197	82	body	body	NN
cord-017764-h1w9gbxk	197	83	weight	weight	NN
cord-017764-h1w9gbxk	197	84	)	)	-RRB-
cord-017764-h1w9gbxk	197	85	administered	administer	VBN
cord-017764-h1w9gbxk	197	86	for	for	IN
cord-017764-h1w9gbxk	197	87	24	24	CD
cord-017764-h1w9gbxk	197	88	weeks	week	NNS
cord-017764-h1w9gbxk	197	89	was	be	VBD
cord-017764-h1w9gbxk	197	90	compared	compare	VBN
cord-017764-h1w9gbxk	197	91	with	with	IN
cord-017764-h1w9gbxk	197	92	a	a	DT
cord-017764-h1w9gbxk	197	93	regimen	regimen	NN
cord-017764-h1w9gbxk	197	94	comprised	comprise	VBN
cord-017764-h1w9gbxk	197	95	of	of	IN
cord-017764-h1w9gbxk	197	96	only	only	RB
cord-017764-h1w9gbxk	197	97	the	the	DT
cord-017764-h1w9gbxk	197	98	two	two	CD
cord-017764-h1w9gbxk	197	99	direct	direct	JJ
cord-017764-h1w9gbxk	197	100	-	-	HYPH
cord-017764-h1w9gbxk	197	101	acting	act	VBG
cord-017764-h1w9gbxk	197	102	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	197	103	agents	agent	NNS
cord-017764-h1w9gbxk	197	104	(	(	-LRB-
cord-017764-h1w9gbxk	197	105	DAAs	DAAs	NNP
cord-017764-h1w9gbxk	197	106	)	)	-RRB-
cord-017764-h1w9gbxk	197	107	[	[	-LRB-
cord-017764-h1w9gbxk	197	108	99	99	CD
cord-017764-h1w9gbxk	197	109	,	,	,
cord-017764-h1w9gbxk	197	110	102	102	CD
cord-017764-h1w9gbxk	197	111	]	]	-RRB-
cord-017764-h1w9gbxk	197	112	.	.	.
cord-017764-h1w9gbxk	198	1	All	all	DT
cord-017764-h1w9gbxk	198	2	of	of	IN
cord-017764-h1w9gbxk	198	3	the	the	DT
cord-017764-h1w9gbxk	198	4	ten	ten	CD
cord-017764-h1w9gbxk	198	5	patients	patient	NNS
cord-017764-h1w9gbxk	198	6	receiving	receive	VBG
cord-017764-h1w9gbxk	198	7	the	the	DT
cord-017764-h1w9gbxk	198	8	quadruple	quadruple	JJ
cord-017764-h1w9gbxk	198	9	drug	drug	NN
cord-017764-h1w9gbxk	198	10	regimen	regimen	NN
cord-017764-h1w9gbxk	198	11	had	have	VBD
cord-017764-h1w9gbxk	198	12	undetectable	undetectable	JJ
cord-017764-h1w9gbxk	198	13	levels	level	NNS
cord-017764-h1w9gbxk	198	14	of	of	IN
cord-017764-h1w9gbxk	198	15	HCV	HCV	NNP
cord-017764-h1w9gbxk	198	16	RNA	RNA	NNP
cord-017764-h1w9gbxk	198	17	in	in	IN
cord-017764-h1w9gbxk	198	18	plasma	plasma	NN
cord-017764-h1w9gbxk	198	19	measured	measure	VBN
cord-017764-h1w9gbxk	198	20	at	at	IN
cord-017764-h1w9gbxk	198	21	12	12	CD
cord-017764-h1w9gbxk	198	22	weeks	week	NNS
cord-017764-h1w9gbxk	198	23	following	follow	VBG
cord-017764-h1w9gbxk	198	24	the	the	DT
cord-017764-h1w9gbxk	198	25	last	last	JJ
cord-017764-h1w9gbxk	198	26	dose	dose	NN
cord-017764-h1w9gbxk	198	27	(	(	-LRB-
cord-017764-h1w9gbxk	198	28	SVR	SVR	NNP
cord-017764-h1w9gbxk	198	29	12	12	CD
cord-017764-h1w9gbxk	198	30	)	)	-RRB-
cord-017764-h1w9gbxk	198	31	,	,	,
cord-017764-h1w9gbxk	198	32	while	while	IN
cord-017764-h1w9gbxk	198	33	nine	nine	CD
cord-017764-h1w9gbxk	198	34	also	also	RB
cord-017764-h1w9gbxk	198	35	achieved	achieve	VBD
cord-017764-h1w9gbxk	198	36	SVR	SVR	NNP
cord-017764-h1w9gbxk	198	37	24	24	CD
cord-017764-h1w9gbxk	198	38	.	.	.
cord-017764-h1w9gbxk	199	1	One	one	CD
cord-017764-h1w9gbxk	199	2	patient	patient	NN
cord-017764-h1w9gbxk	199	3	in	in	IN
cord-017764-h1w9gbxk	199	4	this	this	DT
cord-017764-h1w9gbxk	199	5	group	group	NN
cord-017764-h1w9gbxk	199	6	had	have	VBD
cord-017764-h1w9gbxk	199	7	detectable	detectable	JJ
cord-017764-h1w9gbxk	199	8	HCV	HCV	NNP
cord-017764-h1w9gbxk	199	9	RNA	RNA	NNP
cord-017764-h1w9gbxk	199	10	in	in	IN
cord-017764-h1w9gbxk	199	11	plasma	plasma	NN
cord-017764-h1w9gbxk	199	12	at	at	IN
cord-017764-h1w9gbxk	199	13	week	week	NN
cord-017764-h1w9gbxk	199	14	24	24	CD
cord-017764-h1w9gbxk	199	15	,	,	,
cord-017764-h1w9gbxk	199	16	but	but	CC
cord-017764-h1w9gbxk	199	17	this	this	DT
cord-017764-h1w9gbxk	199	18	was	be	VBD
cord-017764-h1w9gbxk	199	19	not	not	RB
cord-017764-h1w9gbxk	199	20	quantifiable	quantifiable	JJ
cord-017764-h1w9gbxk	199	21	,	,	,
cord-017764-h1w9gbxk	199	22	and	and	CC
cord-017764-h1w9gbxk	199	23	viral	viral	JJ
cord-017764-h1w9gbxk	199	24	RNA	RNA	NNP
cord-017764-h1w9gbxk	199	25	was	be	VBD
cord-017764-h1w9gbxk	199	26	not	not	RB
cord-017764-h1w9gbxk	199	27	detected	detect	VBN
cord-017764-h1w9gbxk	199	28	in	in	IN
cord-017764-h1w9gbxk	199	29	plasma	plasma	NN
cord-017764-h1w9gbxk	199	30	5	5	CD
cord-017764-h1w9gbxk	199	31	weeks	week	NNS
cord-017764-h1w9gbxk	199	32	later	later	RB
cord-017764-h1w9gbxk	200	1	[	[	-LRB-
cord-017764-h1w9gbxk	200	2	99	99	CD
cord-017764-h1w9gbxk	200	3	,	,	,
cord-017764-h1w9gbxk	200	4	102	102	CD
cord-017764-h1w9gbxk	200	5	]	]	-RRB-
cord-017764-h1w9gbxk	200	6	.	.	.
cord-017764-h1w9gbxk	201	1	Of	of	IN
cord-017764-h1w9gbxk	201	2	the	the	DT
cord-017764-h1w9gbxk	201	3	11	11	CD
cord-017764-h1w9gbxk	201	4	patients	patient	NNS
cord-017764-h1w9gbxk	201	5	receiving	receive	VBG
cord-017764-h1w9gbxk	201	6	only	only	RB
cord-017764-h1w9gbxk	201	7	the	the	DT
cord-017764-h1w9gbxk	201	8	dual	dual	JJ
cord-017764-h1w9gbxk	201	9	DAA	DAA	NNP
cord-017764-h1w9gbxk	201	10	combination	combination	NN
cord-017764-h1w9gbxk	201	11	,	,	,
cord-017764-h1w9gbxk	201	12	five	five	CD
cord-017764-h1w9gbxk	201	13	had	have	VBD
cord-017764-h1w9gbxk	201	14	undetectable	undetectable	JJ
cord-017764-h1w9gbxk	201	15	levels	level	NNS
cord-017764-h1w9gbxk	201	16	of	of	IN
cord-017764-h1w9gbxk	201	17	HCV	HCV	NNP
cord-017764-h1w9gbxk	201	18	RNA	RNA	NNP
cord-017764-h1w9gbxk	201	19	in	in	IN
cord-017764-h1w9gbxk	201	20	plasma	plasma	NN
cord-017764-h1w9gbxk	201	21	at	at	IN
cord-017764-h1w9gbxk	201	22	the	the	DT
cord-017764-h1w9gbxk	201	23	end	end	NN
cord-017764-h1w9gbxk	201	24	of	of	IN
cord-017764-h1w9gbxk	201	25	therapy	therapy	NN
cord-017764-h1w9gbxk	201	26	,	,	,
cord-017764-h1w9gbxk	201	27	and	and	CC
cord-017764-h1w9gbxk	201	28	four	four	CD
cord-017764-h1w9gbxk	201	29	maintained	maintain	VBD
cord-017764-h1w9gbxk	201	30	this	this	DT
cord-017764-h1w9gbxk	201	31	status	status	NN
cord-017764-h1w9gbxk	201	32	at	at	IN
cord-017764-h1w9gbxk	201	33	weeks	week	NNS
cord-017764-h1w9gbxk	201	34	4	4	CD
cord-017764-h1w9gbxk	201	35	,	,	,
cord-017764-h1w9gbxk	201	36	12	12	CD
cord-017764-h1w9gbxk	201	37	,	,	,
cord-017764-h1w9gbxk	201	38	and	and	CC
cord-017764-h1w9gbxk	201	39	24	24	CD
cord-017764-h1w9gbxk	201	40	after	after	IN
cord-017764-h1w9gbxk	201	41	the	the	DT
cord-017764-h1w9gbxk	201	42	last	last	JJ
cord-017764-h1w9gbxk	201	43	drug	drug	NN
cord-017764-h1w9gbxk	201	44	dose	dose	NN
cord-017764-h1w9gbxk	201	45	.	.	.
cord-017764-h1w9gbxk	202	1	This	this	DT
cord-017764-h1w9gbxk	202	2	cohort	cohort	NN
cord-017764-h1w9gbxk	202	3	was	be	VBD
cord-017764-h1w9gbxk	202	4	comprised	comprise	VBN
cord-017764-h1w9gbxk	202	5	of	of	IN
cord-017764-h1w9gbxk	202	6	nine	nine	CD
cord-017764-h1w9gbxk	202	7	subjects	subject	NNS
cord-017764-h1w9gbxk	202	8	infected	infect	VBN
cord-017764-h1w9gbxk	202	9	with	with	IN
cord-017764-h1w9gbxk	202	10	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	202	11	and	and	CC
cord-017764-h1w9gbxk	202	12	two	two	CD
cord-017764-h1w9gbxk	202	13	infected	infect	VBN
cord-017764-h1w9gbxk	202	14	with	with	IN
cord-017764-h1w9gbxk	202	15	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	202	16	,	,	,
cord-017764-h1w9gbxk	202	17	with	with	IN
cord-017764-h1w9gbxk	202	18	both	both	DT
cord-017764-h1w9gbxk	202	19	GT-1b	GT-1b	NNS
cord-017764-h1w9gbxk	202	20	-	-	HYPH
cord-017764-h1w9gbxk	202	21	infected	infect	VBN
cord-017764-h1w9gbxk	202	22	patients	patient	NNS
cord-017764-h1w9gbxk	202	23	achieving	achieve	VBG
cord-017764-h1w9gbxk	202	24	SVR	SVR	NNP
cord-017764-h1w9gbxk	202	25	24	24	CD
cord-017764-h1w9gbxk	202	26	,	,	,
cord-017764-h1w9gbxk	202	27	while	while	IN
cord-017764-h1w9gbxk	202	28	six	six	CD
cord-017764-h1w9gbxk	202	29	patients	patient	NNS
cord-017764-h1w9gbxk	202	30	infected	infect	VBN
cord-017764-h1w9gbxk	202	31	with	with	IN
cord-017764-h1w9gbxk	202	32	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	202	33	virus	virus	NN
cord-017764-h1w9gbxk	202	34	experienced	experience	VBD
cord-017764-h1w9gbxk	202	35	virological	virological	JJ
cord-017764-h1w9gbxk	202	36	breakthrough	breakthrough	NN
cord-017764-h1w9gbxk	202	37	while	while	IN
cord-017764-h1w9gbxk	202	38	on	on	IN
cord-017764-h1w9gbxk	202	39	therapy	therapy	NN
cord-017764-h1w9gbxk	202	40	and	and	CC
cord-017764-h1w9gbxk	202	41	the	the	DT
cord-017764-h1w9gbxk	202	42	remaining	remain	VBG
cord-017764-h1w9gbxk	202	43	patient	patient	NN
cord-017764-h1w9gbxk	202	44	infected	infect	VBN
cord-017764-h1w9gbxk	202	45	with	with	IN
cord-017764-h1w9gbxk	202	46	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	202	47	virus	virus	NN
cord-017764-h1w9gbxk	202	48	relapsed	relapse	VBN
cord-017764-h1w9gbxk	202	49	after	after	IN
cord-017764-h1w9gbxk	202	50	completing	complete	VBG
cord-017764-h1w9gbxk	202	51	drug	drug	NN
cord-017764-h1w9gbxk	202	52	therapy	therapy	NN
cord-017764-h1w9gbxk	202	53	.	.	.
cord-017764-h1w9gbxk	203	1	This	this	DT
cord-017764-h1w9gbxk	203	2	study	study	NN
cord-017764-h1w9gbxk	203	3	,	,	,
cord-017764-h1w9gbxk	203	4	which	which	WDT
cord-017764-h1w9gbxk	203	5	was	be	VBD
cord-017764-h1w9gbxk	203	6	conducted	conduct	VBN
cord-017764-h1w9gbxk	203	7	in	in	IN
cord-017764-h1w9gbxk	203	8	a	a	DT
cord-017764-h1w9gbxk	203	9	very	very	RB
cord-017764-h1w9gbxk	203	10	challenging	challenging	JJ
cord-017764-h1w9gbxk	203	11	patient	patient	JJ
cord-017764-h1w9gbxk	203	12	population	population	NN
cord-017764-h1w9gbxk	203	13	,	,	,
cord-017764-h1w9gbxk	203	14	provided	provide	VBD
cord-017764-h1w9gbxk	203	15	the	the	DT
cord-017764-h1w9gbxk	203	16	first	first	JJ
cord-017764-h1w9gbxk	203	17	indication	indication	NN
cord-017764-h1w9gbxk	203	18	that	that	IN
cord-017764-h1w9gbxk	203	19	a	a	DT
cord-017764-h1w9gbxk	203	20	chronic	chronic	JJ
cord-017764-h1w9gbxk	203	21	HCV	HCV	NNP
cord-017764-h1w9gbxk	203	22	infection	infection	NN
cord-017764-h1w9gbxk	203	23	could	could	MD
cord-017764-h1w9gbxk	203	24	be	be	VB
cord-017764-h1w9gbxk	203	25	cured	cure	VBN
cord-017764-h1w9gbxk	203	26	solely	solely	RB
cord-017764-h1w9gbxk	203	27	by	by	IN
cord-017764-h1w9gbxk	203	28	treatment	treatment	NN
cord-017764-h1w9gbxk	203	29	with	with	IN
cord-017764-h1w9gbxk	203	30	DAAs	daa	NNS
cord-017764-h1w9gbxk	203	31	in	in	IN
cord-017764-h1w9gbxk	203	32	the	the	DT
cord-017764-h1w9gbxk	203	33	absence	absence	NN
cord-017764-h1w9gbxk	203	34	of	of	IN
cord-017764-h1w9gbxk	203	35	the	the	DT
cord-017764-h1w9gbxk	203	36	immune	immune	JJ
cord-017764-h1w9gbxk	203	37	stimulation	stimulation	NN
cord-017764-h1w9gbxk	203	38	provided	provide	VBN
cord-017764-h1w9gbxk	203	39	by	by	IN
cord-017764-h1w9gbxk	203	40	peg	peg	NN
cord-017764-h1w9gbxk	203	41	-	-	HYPH
cord-017764-h1w9gbxk	203	42	interferon	interferon	NN
cord-017764-h1w9gbxk	203	43	α2a	α2a	IN
cord-017764-h1w9gbxk	203	44	and	and	CC
cord-017764-h1w9gbxk	203	45	53	53	CD
cord-017764-h1w9gbxk	203	46	[	[	-LRB-
cord-017764-h1w9gbxk	203	47	100	100	CD
cord-017764-h1w9gbxk	203	48	]	]	-RRB-
cord-017764-h1w9gbxk	203	49	.	.	.
cord-017764-h1w9gbxk	204	1	The	the	DT
cord-017764-h1w9gbxk	204	2	successful	successful	JJ
cord-017764-h1w9gbxk	204	3	treatment	treatment	NN
cord-017764-h1w9gbxk	204	4	of	of	IN
cord-017764-h1w9gbxk	204	5	HCV	HCV	NNP
cord-017764-h1w9gbxk	204	6	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	204	7	infections	infection	NNS
cord-017764-h1w9gbxk	204	8	with	with	IN
cord-017764-h1w9gbxk	204	9	1	1	CD
cord-017764-h1w9gbxk	204	10	and	and	CC
cord-017764-h1w9gbxk	204	11	54	54	CD
cord-017764-h1w9gbxk	204	12	redirected	redirect	VBD
cord-017764-h1w9gbxk	204	13	the	the	DT
cord-017764-h1w9gbxk	204	14	clinical	clinical	JJ
cord-017764-h1w9gbxk	204	15	development	development	NN
cord-017764-h1w9gbxk	204	16	plan	plan	NN
cord-017764-h1w9gbxk	204	17	for	for	IN
cord-017764-h1w9gbxk	204	18	this	this	DT
cord-017764-h1w9gbxk	204	19	dual	dual	JJ
cord-017764-h1w9gbxk	204	20	combination	combination	NN
cord-017764-h1w9gbxk	204	21	to	to	IN
cord-017764-h1w9gbxk	204	22	Japan	Japan	NNP
cord-017764-h1w9gbxk	204	23	where	where	WRB
cord-017764-h1w9gbxk	204	24	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	204	25	is	be	VBZ
cord-017764-h1w9gbxk	204	26	the	the	DT
cord-017764-h1w9gbxk	204	27	44	44	CD
cord-017764-h1w9gbxk	204	28	N.	n.	NN
cord-017764-h1w9gbxk	204	29	A.	a.	NN
cord-017764-h1w9gbxk	204	30	Meanwell	Meanwell	NNP
cord-017764-h1w9gbxk	204	31	and	and	CC
cord-017764-h1w9gbxk	204	32	M.	M.	NNP
cord-017764-h1w9gbxk	204	33	Belema	Belema	NNP
cord-017764-h1w9gbxk	204	34	most	most	RBS
cord-017764-h1w9gbxk	204	35	prevalent	prevalent	JJ
cord-017764-h1w9gbxk	204	36	,	,	,
cord-017764-h1w9gbxk	204	37	accounting	account	VBG
cord-017764-h1w9gbxk	204	38	for	for	IN
cord-017764-h1w9gbxk	204	39	approximately	approximately	RB
cord-017764-h1w9gbxk	204	40	70	70	CD
cord-017764-h1w9gbxk	204	41	%	%	NN
cord-017764-h1w9gbxk	204	42	of	of	IN
cord-017764-h1w9gbxk	204	43	the	the	DT
cord-017764-h1w9gbxk	204	44	estimated	estimate	VBN
cord-017764-h1w9gbxk	204	45	two	two	CD
cord-017764-h1w9gbxk	204	46	million	million	CD
cord-017764-h1w9gbxk	204	47	infections	infection	NNS
cord-017764-h1w9gbxk	204	48	at	at	IN
cord-017764-h1w9gbxk	204	49	the	the	DT
cord-017764-h1w9gbxk	204	50	time	time	NN
cord-017764-h1w9gbxk	204	51	[	[	-LRB-
cord-017764-h1w9gbxk	204	52	103	103	CD
cord-017764-h1w9gbxk	204	53	,	,	,
cord-017764-h1w9gbxk	204	54	104	104	CD
cord-017764-h1w9gbxk	204	55	]	]	-RRB-
cord-017764-h1w9gbxk	204	56	.	.	.
cord-017764-h1w9gbxk	205	1	The	the	DT
cord-017764-h1w9gbxk	205	2	combination	combination	NN
cord-017764-h1w9gbxk	205	3	of	of	IN
cord-017764-h1w9gbxk	205	4	1	1	CD
cord-017764-h1w9gbxk	205	5	and	and	CC
cord-017764-h1w9gbxk	205	6	54	54	CD
cord-017764-h1w9gbxk	205	7	has	have	VBZ
cord-017764-h1w9gbxk	205	8	been	be	VBN
cord-017764-h1w9gbxk	205	9	studied	study	VBN
cord-017764-h1w9gbxk	205	10	extensively	extensively	RB
cord-017764-h1w9gbxk	205	11	in	in	IN
cord-017764-h1w9gbxk	205	12	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	205	13	-	-	HYPH
cord-017764-h1w9gbxk	205	14	infected	infect	VBN
cord-017764-h1w9gbxk	205	15	Japanese	japanese	JJ
cord-017764-h1w9gbxk	205	16	patients	patient	NNS
cord-017764-h1w9gbxk	205	17	,	,	,
cord-017764-h1w9gbxk	205	18	leading	lead	VBG
cord-017764-h1w9gbxk	205	19	to	to	IN
cord-017764-h1w9gbxk	205	20	approval	approval	NN
cord-017764-h1w9gbxk	205	21	of	of	IN
cord-017764-h1w9gbxk	205	22	the	the	DT
cord-017764-h1w9gbxk	205	23	drug	drug	NN
cord-017764-h1w9gbxk	205	24	combination	combination	NN
cord-017764-h1w9gbxk	205	25	by	by	IN
cord-017764-h1w9gbxk	205	26	the	the	DT
cord-017764-h1w9gbxk	205	27	Japanese	Japanese	NNP
cord-017764-h1w9gbxk	205	28	Pharmaceutical	Pharmaceutical	NNP
cord-017764-h1w9gbxk	205	29	and	and	CC
cord-017764-h1w9gbxk	205	30	Medical	Medical	NNP
cord-017764-h1w9gbxk	205	31	Devices	Devices	NNPS
cord-017764-h1w9gbxk	205	32	Agency	Agency	NNP
cord-017764-h1w9gbxk	205	33	(	(	-LRB-
cord-017764-h1w9gbxk	205	34	PMDA	PMDA	NNP
cord-017764-h1w9gbxk	205	35	)	)	-RRB-
cord-017764-h1w9gbxk	205	36	on	on	IN
cord-017764-h1w9gbxk	205	37	July	July	NNP
cord-017764-h1w9gbxk	205	38	4	4	CD
cord-017764-h1w9gbxk	205	39	,	,	,
cord-017764-h1w9gbxk	205	40	2014	2014	CD
cord-017764-h1w9gbxk	205	41	[	[	-LRB-
cord-017764-h1w9gbxk	205	42	105	105	CD
cord-017764-h1w9gbxk	205	43	]	]	-RRB-
cord-017764-h1w9gbxk	205	44	[	[	-LRB-
cord-017764-h1w9gbxk	205	45	106	106	CD
cord-017764-h1w9gbxk	205	46	]	]	-RRB-
cord-017764-h1w9gbxk	205	47	[	[	-LRB-
cord-017764-h1w9gbxk	205	48	107	107	CD
cord-017764-h1w9gbxk	205	49	]	]	-RRB-
cord-017764-h1w9gbxk	205	50	[	[	-LRB-
cord-017764-h1w9gbxk	205	51	108	108	CD
cord-017764-h1w9gbxk	205	52	]	]	-RRB-
cord-017764-h1w9gbxk	205	53	[	[	-LRB-
cord-017764-h1w9gbxk	205	54	109	109	CD
cord-017764-h1w9gbxk	205	55	]	]	-RRB-
cord-017764-h1w9gbxk	205	56	[	[	-LRB-
cord-017764-h1w9gbxk	205	57	110	110	CD
cord-017764-h1w9gbxk	205	58	]	]	-RRB-
cord-017764-h1w9gbxk	205	59	[	[	-LRB-
cord-017764-h1w9gbxk	205	60	111	111	CD
cord-017764-h1w9gbxk	205	61	]	]	-RRB-
cord-017764-h1w9gbxk	205	62	[	[	-LRB-
cord-017764-h1w9gbxk	205	63	112	112	CD
cord-017764-h1w9gbxk	205	64	]	]	-RRB-
cord-017764-h1w9gbxk	205	65	[	[	-LRB-
cord-017764-h1w9gbxk	205	66	113	113	CD
cord-017764-h1w9gbxk	205	67	]	]	-RRB-
cord-017764-h1w9gbxk	205	68	[	[	-LRB-
cord-017764-h1w9gbxk	205	69	114	114	CD
cord-017764-h1w9gbxk	205	70	]	]	-RRB-
cord-017764-h1w9gbxk	205	71	[	[	-LRB-
cord-017764-h1w9gbxk	205	72	115	115	CD
cord-017764-h1w9gbxk	205	73	]	]	-RRB-
cord-017764-h1w9gbxk	205	74	[	[	-LRB-
cord-017764-h1w9gbxk	205	75	116	116	CD
cord-017764-h1w9gbxk	205	76	]	]	-RRB-
cord-017764-h1w9gbxk	205	77	[	[	-LRB-
cord-017764-h1w9gbxk	205	78	117	117	CD
cord-017764-h1w9gbxk	205	79	]	]	-RRB-
cord-017764-h1w9gbxk	205	80	[	[	-LRB-
cord-017764-h1w9gbxk	205	81	118	118	CD
cord-017764-h1w9gbxk	205	82	]	]	-RRB-
cord-017764-h1w9gbxk	205	83	[	[	-LRB-
cord-017764-h1w9gbxk	205	84	119	119	CD
cord-017764-h1w9gbxk	205	85	]	]	-RRB-
cord-017764-h1w9gbxk	205	86	.	.	.
cord-017764-h1w9gbxk	206	1	The	the	DT
cord-017764-h1w9gbxk	206	2	marketing	marketing	NN
cord-017764-h1w9gbxk	206	3	authorization	authorization	NN
cord-017764-h1w9gbxk	206	4	of	of	IN
cord-017764-h1w9gbxk	206	5	1	1	CD
cord-017764-h1w9gbxk	206	6	as	as	IN
cord-017764-h1w9gbxk	206	7	Daklinza	Daklinza	NNP
cord-017764-h1w9gbxk	206	8	™	™	NN
cord-017764-h1w9gbxk	206	9	and	and	CC
cord-017764-h1w9gbxk	206	10	54	54	CD
cord-017764-h1w9gbxk	206	11	as	as	IN
cord-017764-h1w9gbxk	207	1	Sunvepra	Sunvepra	NNP
cord-017764-h1w9gbxk	207	2	®	®	VBP
cord-017764-h1w9gbxk	207	3	in	in	IN
cord-017764-h1w9gbxk	207	4	Japan	Japan	NNP
cord-017764-h1w9gbxk	207	5	represented	represent	VBD
cord-017764-h1w9gbxk	207	6	the	the	DT
cord-017764-h1w9gbxk	207	7	first	first	JJ
cord-017764-h1w9gbxk	207	8	approval	approval	NN
cord-017764-h1w9gbxk	207	9	of	of	IN
cord-017764-h1w9gbxk	207	10	a	a	DT
cord-017764-h1w9gbxk	207	11	combination	combination	NN
cord-017764-h1w9gbxk	207	12	of	of	IN
cord-017764-h1w9gbxk	207	13	DAAs	daas	NN
cord-017764-h1w9gbxk	207	14	for	for	IN
cord-017764-h1w9gbxk	207	15	the	the	DT
cord-017764-h1w9gbxk	207	16	treatment	treatment	NN
cord-017764-h1w9gbxk	207	17	of	of	IN
cord-017764-h1w9gbxk	207	18	HCV	HCV	NNP
cord-017764-h1w9gbxk	207	19	infection	infection	NN
cord-017764-h1w9gbxk	207	20	although	although	IN
cord-017764-h1w9gbxk	207	21	the	the	DT
cord-017764-h1w9gbxk	207	22	combination	combination	NN
cord-017764-h1w9gbxk	207	23	of	of	IN
cord-017764-h1w9gbxk	207	24	sofosbuvir	sofosbuvir	NNP
cord-017764-h1w9gbxk	207	25	(	(	-LRB-
cord-017764-h1w9gbxk	207	26	55	55	CD
cord-017764-h1w9gbxk	207	27	)	)	-RRB-
cord-017764-h1w9gbxk	207	28	and	and	CC
cord-017764-h1w9gbxk	207	29	53	53	CD
cord-017764-h1w9gbxk	207	30	had	have	VBD
cord-017764-h1w9gbxk	207	31	been	be	VBN
cord-017764-h1w9gbxk	207	32	approved	approve	VBN
cord-017764-h1w9gbxk	207	33	by	by	IN
cord-017764-h1w9gbxk	207	34	the	the	DT
cord-017764-h1w9gbxk	207	35	FDA	FDA	NNP
cord-017764-h1w9gbxk	207	36	in	in	IN
cord-017764-h1w9gbxk	207	37	December	December	NNP
cord-017764-h1w9gbxk	207	38	of	of	IN
cord-017764-h1w9gbxk	207	39	2013	2013	CD
cord-017764-h1w9gbxk	207	40	[	[	-LRB-
cord-017764-h1w9gbxk	207	41	107	107	CD
cord-017764-h1w9gbxk	207	42	]	]	-RRB-
cord-017764-h1w9gbxk	207	43	.	.	.
cord-017764-h1w9gbxk	208	1	The	the	DT
cord-017764-h1w9gbxk	208	2	phase	phase	NN
cord-017764-h1w9gbxk	208	3	III	iii	CD
cord-017764-h1w9gbxk	208	4	Japanese	japanese	JJ
cord-017764-h1w9gbxk	208	5	clinical	clinical	JJ
cord-017764-h1w9gbxk	208	6	trials	trial	NNS
cord-017764-h1w9gbxk	208	7	of	of	IN
cord-017764-h1w9gbxk	208	8	1	1	CD
cord-017764-h1w9gbxk	208	9	(	(	-LRB-
cord-017764-h1w9gbxk	208	10	60	60	CD
cord-017764-h1w9gbxk	208	11	mg	mg	NNP
cord-017764-h1w9gbxk	208	12	QD	QD	NNP
cord-017764-h1w9gbxk	208	13	)	)	-RRB-
cord-017764-h1w9gbxk	208	14	and	and	CC
cord-017764-h1w9gbxk	208	15	54	54	CD
cord-017764-h1w9gbxk	208	16	(	(	-LRB-
cord-017764-h1w9gbxk	208	17	100	100	CD
cord-017764-h1w9gbxk	208	18	mg	mg	NNP
cord-017764-h1w9gbxk	208	19	BID	BID	NNP
cord-017764-h1w9gbxk	208	20	)	)	-RRB-
cord-017764-h1w9gbxk	208	21	in	in	IN
cord-017764-h1w9gbxk	208	22	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	208	23	-	-	HYPH
cord-017764-h1w9gbxk	208	24	infected	infect	VBN
cord-017764-h1w9gbxk	208	25	subjects	subject	NNS
cord-017764-h1w9gbxk	208	26	that	that	WDT
cord-017764-h1w9gbxk	208	27	subtended	subtend	VBD
cord-017764-h1w9gbxk	208	28	marketing	marketing	NN
cord-017764-h1w9gbxk	208	29	approval	approval	NN
cord-017764-h1w9gbxk	208	30	evaluated	evaluate	VBD
cord-017764-h1w9gbxk	208	31	24	24	CD
cord-017764-h1w9gbxk	208	32	weeks	week	NNS
cord-017764-h1w9gbxk	208	33	of	of	IN
cord-017764-h1w9gbxk	208	34	therapy	therapy	NN
cord-017764-h1w9gbxk	208	35	and	and	CC
cord-017764-h1w9gbxk	208	36	were	be	VBD
cord-017764-h1w9gbxk	208	37	associated	associate	VBN
cord-017764-h1w9gbxk	208	38	with	with	IN
cord-017764-h1w9gbxk	208	39	SVR	SVR	NNP
cord-017764-h1w9gbxk	208	40	12	12	CD
cord-017764-h1w9gbxk	208	41	rates	rate	NNS
cord-017764-h1w9gbxk	208	42	of	of	IN
cord-017764-h1w9gbxk	208	43	81	81	CD
cord-017764-h1w9gbxk	208	44	%	%	NN
cord-017764-h1w9gbxk	208	45	in	in	IN
cord-017764-h1w9gbxk	208	46	non	non	NNS
cord-017764-h1w9gbxk	208	47	-	-	NNS
cord-017764-h1w9gbxk	208	48	responders	responder	NNS
cord-017764-h1w9gbxk	208	49	and	and	CC
cord-017764-h1w9gbxk	208	50	87	87	CD
cord-017764-h1w9gbxk	208	51	%	%	NN
cord-017764-h1w9gbxk	208	52	in	in	IN
cord-017764-h1w9gbxk	208	53	those	those	DT
cord-017764-h1w9gbxk	208	54	intolerant	intolerant	JJ
cord-017764-h1w9gbxk	208	55	of	of	IN
cord-017764-h1w9gbxk	208	56	or	or	CC
cord-017764-h1w9gbxk	208	57	ineligible	ineligible	JJ
cord-017764-h1w9gbxk	208	58	for	for	IN
cord-017764-h1w9gbxk	208	59	pegylated	pegylated	JJ
cord-017764-h1w9gbxk	208	60	interferon	interferon	NN
cord-017764-h1w9gbxk	208	61	therapy	therapy	NN
cord-017764-h1w9gbxk	208	62	.	.	.
cord-017764-h1w9gbxk	209	1	In	in	IN
cord-017764-h1w9gbxk	209	2	a	a	DT
cord-017764-h1w9gbxk	209	3	multinational	multinational	JJ
cord-017764-h1w9gbxk	209	4	study	study	NN
cord-017764-h1w9gbxk	209	5	conducted	conduct	VBN
cord-017764-h1w9gbxk	209	6	in	in	IN
cord-017764-h1w9gbxk	209	7	a	a	DT
cord-017764-h1w9gbxk	209	8	broad	broad	JJ
cord-017764-h1w9gbxk	209	9	GT-1b	GT-1b	NNP
cord-017764-h1w9gbxk	209	10	patient	patient	JJ
cord-017764-h1w9gbxk	209	11	population	population	NN
cord-017764-h1w9gbxk	209	12	,	,	,
cord-017764-h1w9gbxk	209	13	the	the	DT
cord-017764-h1w9gbxk	209	14	SVR	SVR	NNP
cord-017764-h1w9gbxk	209	15	12	12	CD
cord-017764-h1w9gbxk	209	16	rates	rate	NNS
cord-017764-h1w9gbxk	209	17	were	be	VBD
cord-017764-h1w9gbxk	209	18	90	90	CD
cord-017764-h1w9gbxk	209	19	%	%	NN
cord-017764-h1w9gbxk	209	20	in	in	IN
cord-017764-h1w9gbxk	209	21	those	those	DT
cord-017764-h1w9gbxk	209	22	naïve	naïve	JJ
cord-017764-h1w9gbxk	209	23	to	to	IN
cord-017764-h1w9gbxk	209	24	therapy	therapy	NN
cord-017764-h1w9gbxk	209	25	and	and	CC
cord-017764-h1w9gbxk	209	26	82	82	CD
cord-017764-h1w9gbxk	209	27	%	%	NN
cord-017764-h1w9gbxk	209	28	in	in	IN
cord-017764-h1w9gbxk	209	29	those	those	DT
cord-017764-h1w9gbxk	209	30	intolerant	intolerant	JJ
cord-017764-h1w9gbxk	209	31	of	of	IN
cord-017764-h1w9gbxk	209	32	or	or	CC
cord-017764-h1w9gbxk	209	33	ineligible	ineligible	JJ
cord-017764-h1w9gbxk	209	34	for	for	IN
cord-017764-h1w9gbxk	209	35	interferon	interferon	NN
cord-017764-h1w9gbxk	209	36	-	-	HYPH
cord-017764-h1w9gbxk	209	37	based	base	VBN
cord-017764-h1w9gbxk	209	38	therapies	therapy	NNS
cord-017764-h1w9gbxk	209	39	.	.	.
cord-017764-h1w9gbxk	210	1	The	the	DT
cord-017764-h1w9gbxk	210	2	pre	pre	NN
cord-017764-h1w9gbxk	210	3	-	-	NN
cord-017764-h1w9gbxk	210	4	existence	existence	NN
cord-017764-h1w9gbxk	210	5	of	of	IN
cord-017764-h1w9gbxk	210	6	the	the	DT
cord-017764-h1w9gbxk	210	7	Tyr93His	Tyr93His	NNP
cord-017764-h1w9gbxk	210	8	polymorphism	polymorphism	NN
cord-017764-h1w9gbxk	210	9	in	in	IN
cord-017764-h1w9gbxk	210	10	the	the	DT
cord-017764-h1w9gbxk	210	11	HCV	HCV	NNP
cord-017764-h1w9gbxk	211	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	211	2	gene	gene	NN
cord-017764-h1w9gbxk	211	3	was	be	VBD
cord-017764-h1w9gbxk	211	4	a	a	DT
cord-017764-h1w9gbxk	211	5	predictor	predictor	NN
cord-017764-h1w9gbxk	211	6	of	of	IN
cord-017764-h1w9gbxk	211	7	lower	low	JJR
cord-017764-h1w9gbxk	211	8	clinical	clinical	JJ
cord-017764-h1w9gbxk	211	9	efficacy	efficacy	NN
cord-017764-h1w9gbxk	211	10	,	,	,
cord-017764-h1w9gbxk	211	11	with	with	IN
cord-017764-h1w9gbxk	211	12	the	the	DT
cord-017764-h1w9gbxk	211	13	SVR	SVR	NNP
cord-017764-h1w9gbxk	211	14	rates	rate	NNS
cord-017764-h1w9gbxk	211	15	declining	decline	VBG
cord-017764-h1w9gbxk	211	16	to	to	IN
cord-017764-h1w9gbxk	211	17	45	45	CD
cord-017764-h1w9gbxk	211	18	from	from	IN
cord-017764-h1w9gbxk	211	19	95	95	CD
cord-017764-h1w9gbxk	211	20	%	%	NN
cord-017764-h1w9gbxk	211	21	in	in	IN
cord-017764-h1w9gbxk	211	22	those	those	DT
cord-017764-h1w9gbxk	211	23	patients	patient	NNS
cord-017764-h1w9gbxk	211	24	that	that	WDT
cord-017764-h1w9gbxk	211	25	harbored	harbor	VBD
cord-017764-h1w9gbxk	211	26	this	this	DT
cord-017764-h1w9gbxk	211	27	mutation	mutation	NN
cord-017764-h1w9gbxk	211	28	at	at	IN
cord-017764-h1w9gbxk	211	29	baseline	baseline	NN
cord-017764-h1w9gbxk	211	30	,	,	,
cord-017764-h1w9gbxk	211	31	which	which	WDT
cord-017764-h1w9gbxk	211	32	has	have	VBZ
cord-017764-h1w9gbxk	211	33	a	a	DT
cord-017764-h1w9gbxk	211	34	15	15	CD
cord-017764-h1w9gbxk	211	35	%	%	NN
cord-017764-h1w9gbxk	211	36	prevalence	prevalence	NN
cord-017764-h1w9gbxk	211	37	in	in	IN
cord-017764-h1w9gbxk	211	38	the	the	DT
cord-017764-h1w9gbxk	211	39	Japanese	japanese	JJ
cord-017764-h1w9gbxk	211	40	patient	patient	NN
cord-017764-h1w9gbxk	211	41	population	population	NN
cord-017764-h1w9gbxk	211	42	.	.	.
cord-017764-h1w9gbxk	212	1	Broadening	broaden	VBG
cord-017764-h1w9gbxk	212	2	the	the	DT
cord-017764-h1w9gbxk	212	3	utility	utility	NN
cord-017764-h1w9gbxk	212	4	of	of	IN
cord-017764-h1w9gbxk	212	5	1	1	CD
cord-017764-h1w9gbxk	212	6	and	and	CC
cord-017764-h1w9gbxk	212	7	54	54	CD
cord-017764-h1w9gbxk	212	8	to	to	TO
cord-017764-h1w9gbxk	212	9	treat	treat	VB
cord-017764-h1w9gbxk	212	10	HCV	HCV	NNP
cord-017764-h1w9gbxk	212	11	GT-1a	GT-1a	NNP
cord-017764-h1w9gbxk	212	12	infections	infection	NNS
cord-017764-h1w9gbxk	212	13	required	require	VBD
cord-017764-h1w9gbxk	212	14	the	the	DT
cord-017764-h1w9gbxk	212	15	addition	addition	NN
cord-017764-h1w9gbxk	212	16	of	of	IN
cord-017764-h1w9gbxk	212	17	a	a	DT
cord-017764-h1w9gbxk	212	18	third	third	JJ
cord-017764-h1w9gbxk	212	19	agent	agent	NN
cord-017764-h1w9gbxk	212	20	,	,	,
cord-017764-h1w9gbxk	212	21	the	the	DT
cord-017764-h1w9gbxk	212	22	allosteric	allosteric	JJ
cord-017764-h1w9gbxk	212	23	RNA	RNA	NNP
cord-017764-h1w9gbxk	212	24	-	-	HYPH
cord-017764-h1w9gbxk	212	25	dependent	dependent	JJ
cord-017764-h1w9gbxk	212	26	RNA	RNA	NNP
cord-017764-h1w9gbxk	212	27	polymerase	polymerase	NN
cord-017764-h1w9gbxk	212	28	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	212	29	beclabuvir	beclabuvir	NNS
cord-017764-h1w9gbxk	212	30	(	(	-LRB-
cord-017764-h1w9gbxk	212	31	56	56	CD
cord-017764-h1w9gbxk	212	32	)	)	-RRB-
cord-017764-h1w9gbxk	212	33	which	which	WDT
cord-017764-h1w9gbxk	212	34	was	be	VBD
cord-017764-h1w9gbxk	212	35	developed	develop	VBN
cord-017764-h1w9gbxk	212	36	as	as	IN
cord-017764-h1w9gbxk	212	37	a	a	DT
cord-017764-h1w9gbxk	212	38	fixed	fix	VBN
cord-017764-h1w9gbxk	212	39	-	-	HYPH
cord-017764-h1w9gbxk	212	40	dose	dose	NN
cord-017764-h1w9gbxk	212	41	combination	combination	NN
cord-017764-h1w9gbxk	212	42	comprising	comprise	VBG
cord-017764-h1w9gbxk	212	43	of	of	IN
cord-017764-h1w9gbxk	212	44	30	30	CD
cord-017764-h1w9gbxk	212	45	mg	mg	NN
cord-017764-h1w9gbxk	212	46	of	of	IN
cord-017764-h1w9gbxk	212	47	1	1	CD
cord-017764-h1w9gbxk	212	48	,	,	,
cord-017764-h1w9gbxk	212	49	200	200	CD
cord-017764-h1w9gbxk	212	50	mg	mg	CD
cord-017764-h1w9gbxk	212	51	of	of	IN
cord-017764-h1w9gbxk	212	52	54	54	CD
cord-017764-h1w9gbxk	212	53	,	,	,
cord-017764-h1w9gbxk	212	54	and	and	CC
cord-017764-h1w9gbxk	212	55	75	75	CD
cord-017764-h1w9gbxk	212	56	mg	mg	NN
cord-017764-h1w9gbxk	212	57	of	of	IN
cord-017764-h1w9gbxk	212	58	56	56	CD
cord-017764-h1w9gbxk	212	59	administered	administer	VBN
cord-017764-h1w9gbxk	212	60	as	as	IN
cord-017764-h1w9gbxk	212	61	a	a	DT
cord-017764-h1w9gbxk	212	62	BID	BID	NNP
cord-017764-h1w9gbxk	212	63	regimen	regimen	NN
cord-017764-h1w9gbxk	212	64	for	for	IN
cord-017764-h1w9gbxk	212	65	12	12	CD
cord-017764-h1w9gbxk	212	66	weeks	week	NNS
cord-017764-h1w9gbxk	212	67	[	[	-LRB-
cord-017764-h1w9gbxk	212	68	120	120	CD
cord-017764-h1w9gbxk	212	69	]	]	-RRB-
cord-017764-h1w9gbxk	212	70	[	[	-LRB-
cord-017764-h1w9gbxk	212	71	121	121	CD
cord-017764-h1w9gbxk	212	72	]	]	-RRB-
cord-017764-h1w9gbxk	212	73	[	[	-LRB-
cord-017764-h1w9gbxk	212	74	122	122	CD
cord-017764-h1w9gbxk	212	75	]	]	-RRB-
cord-017764-h1w9gbxk	212	76	[	[	-LRB-
cord-017764-h1w9gbxk	212	77	123	123	CD
cord-017764-h1w9gbxk	212	78	]	]	-RRB-
cord-017764-h1w9gbxk	212	79	[	[	-LRB-
cord-017764-h1w9gbxk	212	80	124	124	CD
cord-017764-h1w9gbxk	212	81	]	]	-RRB-
cord-017764-h1w9gbxk	213	1	[	[	-LRB-
cord-017764-h1w9gbxk	213	2	125	125	CD
cord-017764-h1w9gbxk	213	3	]	]	-RRB-
cord-017764-h1w9gbxk	213	4	[	[	-LRB-
cord-017764-h1w9gbxk	213	5	126	126	CD
cord-017764-h1w9gbxk	213	6	]	]	-RRB-
cord-017764-h1w9gbxk	213	7	.	.	.
cord-017764-h1w9gbxk	214	1	In	in	IN
cord-017764-h1w9gbxk	214	2	the	the	DT
cord-017764-h1w9gbxk	214	3	UNITY	unity	NN
cord-017764-h1w9gbxk	214	4	1	1	CD
cord-017764-h1w9gbxk	214	5	international	international	JJ
cord-017764-h1w9gbxk	214	6	study	study	NN
cord-017764-h1w9gbxk	214	7	which	which	WDT
cord-017764-h1w9gbxk	214	8	was	be	VBD
cord-017764-h1w9gbxk	214	9	conducted	conduct	VBN
cord-017764-h1w9gbxk	214	10	in	in	IN
cord-017764-h1w9gbxk	214	11	415	415	CD
cord-017764-h1w9gbxk	214	12	non	non	JJ
cord-017764-h1w9gbxk	214	13	-	-	JJ
cord-017764-h1w9gbxk	214	14	cirrhotic	cirrhotic	JJ
cord-017764-h1w9gbxk	214	15	patients	patient	NNS
cord-017764-h1w9gbxk	214	16	with	with	IN
cord-017764-h1w9gbxk	214	17	HCV	HCV	NNP
cord-017764-h1w9gbxk	214	18	GT-1	GT-1	NNP
cord-017764-h1w9gbxk	214	19	infection	infection	NN
cord-017764-h1w9gbxk	214	20	,	,	,
cord-017764-h1w9gbxk	214	21	91	91	CD
cord-017764-h1w9gbxk	214	22	%	%	NN
cord-017764-h1w9gbxk	214	23	of	of	IN
cord-017764-h1w9gbxk	214	24	the	the	DT
cord-017764-h1w9gbxk	214	25	patients	patient	NNS
cord-017764-h1w9gbxk	214	26	achieved	achieve	VBD
cord-017764-h1w9gbxk	214	27	SVR	SVR	NNP
cord-017764-h1w9gbxk	214	28	12	12	CD
cord-017764-h1w9gbxk	214	29	.	.	.
cord-017764-h1w9gbxk	215	1	SVR	SVR	NNP
cord-017764-h1w9gbxk	215	2	12	12	CD
cord-017764-h1w9gbxk	215	3	rates	rate	NNS
cord-017764-h1w9gbxk	215	4	of	of	IN
cord-017764-h1w9gbxk	215	5	92	92	CD
cord-017764-h1w9gbxk	215	6	%	%	NN
cord-017764-h1w9gbxk	215	7	were	be	VBD
cord-017764-h1w9gbxk	215	8	observed	observe	VBN
cord-017764-h1w9gbxk	215	9	in	in	IN
cord-017764-h1w9gbxk	215	10	treatment	treatment	NN
cord-017764-h1w9gbxk	215	11	-	-	HYPH
cord-017764-h1w9gbxk	215	12	naive	naive	JJ
cord-017764-h1w9gbxk	215	13	patients	patient	NNS
cord-017764-h1w9gbxk	215	14	and	and	CC
cord-017764-h1w9gbxk	215	15	89	89	CD
cord-017764-h1w9gbxk	215	16	%	%	NN
cord-017764-h1w9gbxk	215	17	in	in	IN
cord-017764-h1w9gbxk	215	18	treatment	treatment	NN
cord-017764-h1w9gbxk	215	19	-	-	HYPH
cord-017764-h1w9gbxk	215	20	experienced	experience	VBN
cord-017764-h1w9gbxk	215	21	patients	patient	NNS
cord-017764-h1w9gbxk	215	22	,	,	,
cord-017764-h1w9gbxk	215	23	while	while	IN
cord-017764-h1w9gbxk	215	24	virologic	virologic	JJ
cord-017764-h1w9gbxk	215	25	failure	failure	NN
cord-017764-h1w9gbxk	215	26	occurred	occur	VBD
cord-017764-h1w9gbxk	215	27	in	in	IN
cord-017764-h1w9gbxk	215	28	8	8	CD
cord-017764-h1w9gbxk	215	29	%	%	NN
cord-017764-h1w9gbxk	215	30	of	of	IN
cord-017764-h1w9gbxk	215	31	the	the	DT
cord-017764-h1w9gbxk	215	32	patients	patient	NNS
cord-017764-h1w9gbxk	215	33	.	.	.
cord-017764-h1w9gbxk	216	1	In	in	IN
cord-017764-h1w9gbxk	216	2	the	the	DT
cord-017764-h1w9gbxk	216	3	UNITY-2	UNITY-2	NNP
cord-017764-h1w9gbxk	216	4	phase	phase	NN
cord-017764-h1w9gbxk	216	5	III	iii	CD
cord-017764-h1w9gbxk	216	6	study	study	NN
cord-017764-h1w9gbxk	216	7	conducted	conduct	VBN
cord-017764-h1w9gbxk	216	8	in	in	IN
cord-017764-h1w9gbxk	216	9	the	the	DT
cord-017764-h1w9gbxk	216	10	United	United	NNP
cord-017764-h1w9gbxk	216	11	States	States	NNP
cord-017764-h1w9gbxk	216	12	,	,	,
cord-017764-h1w9gbxk	216	13	Canada	Canada	NNP
cord-017764-h1w9gbxk	216	14	,	,	,
cord-017764-h1w9gbxk	216	15	France	France	NNP
cord-017764-h1w9gbxk	216	16	,	,	,
cord-017764-h1w9gbxk	216	17	and	and	CC
cord-017764-h1w9gbxk	216	18	Australia	Australia	NNP
cord-017764-h1w9gbxk	216	19	in	in	IN
cord-017764-h1w9gbxk	216	20	202	202	CD
cord-017764-h1w9gbxk	216	21	GT-1-infected	gt-1-infected	CD
cord-017764-h1w9gbxk	216	22	patients	patient	NNS
cord-017764-h1w9gbxk	216	23	with	with	IN
cord-017764-h1w9gbxk	216	24	compensated	compensate	VBN
cord-017764-h1w9gbxk	216	25	cirrhosis	cirrhosis	NN
cord-017764-h1w9gbxk	216	26	,	,	,
cord-017764-h1w9gbxk	216	27	the	the	DT
cord-017764-h1w9gbxk	216	28	SVR	SVR	NNP
cord-017764-h1w9gbxk	216	29	12	12	CD
cord-017764-h1w9gbxk	216	30	rates	rate	NNS
cord-017764-h1w9gbxk	216	31	were	be	VBD
cord-017764-h1w9gbxk	216	32	93	93	CD
cord-017764-h1w9gbxk	216	33	%	%	NN
cord-017764-h1w9gbxk	216	34	for	for	IN
cord-017764-h1w9gbxk	216	35	patients	patient	NNS
cord-017764-h1w9gbxk	216	36	in	in	IN
cord-017764-h1w9gbxk	216	37	the	the	DT
cord-017764-h1w9gbxk	216	38	treatment	treatment	NN
cord-017764-h1w9gbxk	216	39	-	-	HYPH
cord-017764-h1w9gbxk	216	40	naive	naive	JJ
cord-017764-h1w9gbxk	216	41	group	group	NN
cord-017764-h1w9gbxk	216	42	and	and	CC
cord-017764-h1w9gbxk	216	43	87	87	CD
cord-017764-h1w9gbxk	216	44	%	%	NN
cord-017764-h1w9gbxk	216	45	for	for	IN
cord-017764-h1w9gbxk	216	46	those	those	DT
cord-017764-h1w9gbxk	216	47	in	in	IN
cord-017764-h1w9gbxk	216	48	the	the	DT
cord-017764-h1w9gbxk	216	49	treatment	treatment	NN
cord-017764-h1w9gbxk	216	50	-	-	HYPH
cord-017764-h1w9gbxk	216	51	experienced	experience	VBN
cord-017764-h1w9gbxk	216	52	group	group	NN
cord-017764-h1w9gbxk	216	53	.	.	.
cord-017764-h1w9gbxk	217	1	SVR	SVR	NNP
cord-017764-h1w9gbxk	217	2	12	12	CD
cord-017764-h1w9gbxk	217	3	rates	rate	NNS
cord-017764-h1w9gbxk	217	4	were	be	VBD
cord-017764-h1w9gbxk	217	5	improved	improve	VBN
cord-017764-h1w9gbxk	217	6	to	to	IN
cord-017764-h1w9gbxk	217	7	98	98	CD
cord-017764-h1w9gbxk	217	8	%	%	NN
cord-017764-h1w9gbxk	217	9	for	for	IN
cord-017764-h1w9gbxk	217	10	patients	patient	NNS
cord-017764-h1w9gbxk	217	11	in	in	IN
cord-017764-h1w9gbxk	217	12	the	the	DT
cord-017764-h1w9gbxk	217	13	treatment	treatment	NN
cord-017764-h1w9gbxk	217	14	-	-	HYPH
cord-017764-h1w9gbxk	217	15	naive	naive	JJ
cord-017764-h1w9gbxk	217	16	group	group	NN
cord-017764-h1w9gbxk	217	17	and	and	CC
cord-017764-h1w9gbxk	217	18	93	93	CD
cord-017764-h1w9gbxk	217	19	%	%	NN
cord-017764-h1w9gbxk	217	20	for	for	IN
cord-017764-h1w9gbxk	217	21	those	those	DT
cord-017764-h1w9gbxk	217	22	in	in	IN
cord-017764-h1w9gbxk	217	23	the	the	DT
cord-017764-h1w9gbxk	217	24	treatment	treatment	NN
cord-017764-h1w9gbxk	217	25	-	-	HYPH
cord-017764-h1w9gbxk	217	26	experienced	experience	VBN
cord-017764-h1w9gbxk	217	27	group	group	NN
cord-017764-h1w9gbxk	217	28	when	when	WRB
cord-017764-h1w9gbxk	217	29	53	53	CD
cord-017764-h1w9gbxk	217	30	was	be	VBD
cord-017764-h1w9gbxk	217	31	included	include	VBN
cord-017764-h1w9gbxk	217	32	in	in	IN
cord-017764-h1w9gbxk	217	33	the	the	DT
cord-017764-h1w9gbxk	217	34	regimen	regimen	NN
cord-017764-h1w9gbxk	217	35	.	.	.
cord-017764-h1w9gbxk	218	1	In	in	IN
cord-017764-h1w9gbxk	218	2	a	a	DT
cord-017764-h1w9gbxk	218	3	phase	phase	NN
cord-017764-h1w9gbxk	218	4	III	iii	CD
cord-017764-h1w9gbxk	218	5	trial	trial	NN
cord-017764-h1w9gbxk	218	6	(	(	-LRB-
cord-017764-h1w9gbxk	218	7	UNITY	UNITY	NNP
cord-017764-h1w9gbxk	218	8	3	3	CD
cord-017764-h1w9gbxk	218	9	)	)	-RRB-
cord-017764-h1w9gbxk	218	10	conducted	conduct	VBN
cord-017764-h1w9gbxk	218	11	in	in	IN
cord-017764-h1w9gbxk	218	12	217	217	CD
cord-017764-h1w9gbxk	218	13	Japanese	japanese	JJ
cord-017764-h1w9gbxk	218	14	patients	patient	NNS
cord-017764-h1w9gbxk	218	15	infected	infect	VBN
cord-017764-h1w9gbxk	218	16	with	with	IN
cord-017764-h1w9gbxk	218	17	GT-1	GT-1	NNP
cord-017764-h1w9gbxk	218	18	HCV	HCV	NNP
cord-017764-h1w9gbxk	218	19	,	,	,
cord-017764-h1w9gbxk	218	20	SVR	SVR	NNP
cord-017764-h1w9gbxk	218	21	12	12	CD
cord-017764-h1w9gbxk	218	22	rates	rate	NNS
cord-017764-h1w9gbxk	218	23	of	of	IN
cord-017764-h1w9gbxk	218	24	95	95	CD
cord-017764-h1w9gbxk	218	25	%	%	NN
cord-017764-h1w9gbxk	218	26	were	be	VBD
cord-017764-h1w9gbxk	218	27	achieved	achieve	VBN
cord-017764-h1w9gbxk	218	28	in	in	IN
cord-017764-h1w9gbxk	218	29	both	both	DT
cord-017764-h1w9gbxk	218	30	treatment	treatment	NN
cord-017764-h1w9gbxk	218	31	-	-	HYPH
cord-017764-h1w9gbxk	218	32	naive	naive	JJ
cord-017764-h1w9gbxk	218	33	(	(	-LRB-
cord-017764-h1w9gbxk	218	34	n	n	NN
cord-017764-h1w9gbxk	218	35	¼	¼	NNP
cord-017764-h1w9gbxk	218	36	152	152	CD
cord-017764-h1w9gbxk	218	37	)	)	-RRB-
cord-017764-h1w9gbxk	218	38	and	and	CC
cord-017764-h1w9gbxk	218	39	interferon	interferon	NN
cord-017764-h1w9gbxk	218	40	-	-	HYPH
cord-017764-h1w9gbxk	218	41	experienced	experience	VBN
cord-017764-h1w9gbxk	218	42	(	(	-LRB-
cord-017764-h1w9gbxk	218	43	n	n	NN
cord-017764-h1w9gbxk	218	44	¼	¼	NNP
cord-017764-h1w9gbxk	218	45	65	65	CD
cord-017764-h1w9gbxk	218	46	)	)	-RRB-
cord-017764-h1w9gbxk	218	47	cohorts	cohort	NNS
cord-017764-h1w9gbxk	218	48	after	after	IN
cord-017764-h1w9gbxk	218	49	12	12	CD
cord-017764-h1w9gbxk	218	50	weeks	week	NNS
cord-017764-h1w9gbxk	218	51	of	of	IN
cord-017764-h1w9gbxk	218	52	therapy	therapy	NN
cord-017764-h1w9gbxk	218	53	.	.	.
cord-017764-h1w9gbxk	219	1	The	the	DT
cord-017764-h1w9gbxk	219	2	SVR	SVR	NNP
cord-017764-h1w9gbxk	219	3	12	12	CD
cord-017764-h1w9gbxk	219	4	rates	rate	NNS
cord-017764-h1w9gbxk	219	5	were	be	VBD
cord-017764-h1w9gbxk	219	6	similar	similar	JJ
cord-017764-h1w9gbxk	219	7	across	across	IN
cord-017764-h1w9gbxk	219	8	the	the	DT
cord-017764-h1w9gbxk	219	9	patient	patient	NN
cord-017764-h1w9gbxk	219	10	subgroups	subgroup	NNS
cord-017764-h1w9gbxk	219	11	evaluated	evaluate	VBD
cord-017764-h1w9gbxk	219	12	that	that	IN
cord-017764-h1w9gbxk	219	13	included	include	VBD
cord-017764-h1w9gbxk	219	14	patients	patient	NNS
cord-017764-h1w9gbxk	219	15	with	with	IN
cord-017764-h1w9gbxk	219	16	cirrhosis	cirrhosis	NN
cord-017764-h1w9gbxk	219	17	and	and	CC
cord-017764-h1w9gbxk	219	18	those	those	DT
cord-017764-h1w9gbxk	219	19	aged	aged	JJ
cord-017764-h1w9gbxk	219	20	65	65	CD
cord-017764-h1w9gbxk	219	21	years	year	NNS
cord-017764-h1w9gbxk	219	22	.	.	.
cord-017764-h1w9gbxk	220	1	These	these	DT
cord-017764-h1w9gbxk	220	2	studies	study	NNS
cord-017764-h1w9gbxk	220	3	contributed	contribute	VBD
cord-017764-h1w9gbxk	220	4	to	to	IN
cord-017764-h1w9gbxk	220	5	the	the	DT
cord-017764-h1w9gbxk	220	6	approval	approval	NN
cord-017764-h1w9gbxk	220	7	of	of	IN
cord-017764-h1w9gbxk	220	8	the	the	DT
cord-017764-h1w9gbxk	220	9	fixed	fix	VBN
cord-017764-h1w9gbxk	220	10	-	-	HYPH
cord-017764-h1w9gbxk	220	11	dose	dose	NN
cord-017764-h1w9gbxk	220	12	combination	combination	NN
cord-017764-h1w9gbxk	220	13	of	of	IN
cord-017764-h1w9gbxk	220	14	1	1	CD
cord-017764-h1w9gbxk	220	15	,	,	,
cord-017764-h1w9gbxk	220	16	54	54	CD
cord-017764-h1w9gbxk	220	17	,	,	,
cord-017764-h1w9gbxk	220	18	and	and	CC
cord-017764-h1w9gbxk	220	19	56	56	CD
cord-017764-h1w9gbxk	220	20	for	for	IN
cord-017764-h1w9gbxk	220	21	marketing	marketing	NN
cord-017764-h1w9gbxk	220	22	in	in	IN
cord-017764-h1w9gbxk	220	23	Japan	Japan	NNP
cord-017764-h1w9gbxk	220	24	on	on	IN
cord-017764-h1w9gbxk	220	25	December	December	NNP
cord-017764-h1w9gbxk	220	26	20	20	CD
cord-017764-h1w9gbxk	220	27	,	,	,
cord-017764-h1w9gbxk	220	28	2016	2016	CD
cord-017764-h1w9gbxk	220	29	.	.	.
cord-017764-h1w9gbxk	221	1	A	a	DT
cord-017764-h1w9gbxk	221	2	number	number	NN
cord-017764-h1w9gbxk	221	3	of	of	IN
cord-017764-h1w9gbxk	221	4	clinical	clinical	JJ
cord-017764-h1w9gbxk	221	5	studies	study	NNS
cord-017764-h1w9gbxk	221	6	have	have	VBP
cord-017764-h1w9gbxk	221	7	demonstrated	demonstrate	VBN
cord-017764-h1w9gbxk	221	8	that	that	IN
cord-017764-h1w9gbxk	221	9	co	co	NN
cord-017764-h1w9gbxk	221	10	-	-	NN
cord-017764-h1w9gbxk	221	11	dosing	dosing	NN
cord-017764-h1w9gbxk	221	12	of	of	IN
cord-017764-h1w9gbxk	221	13	1	1	CD
cord-017764-h1w9gbxk	221	14	with	with	IN
cord-017764-h1w9gbxk	221	15	the	the	DT
cord-017764-h1w9gbxk	221	16	nucleoside	nucleoside	NN
cord-017764-h1w9gbxk	221	17	-	-	HYPH
cord-017764-h1w9gbxk	221	18	based	base	VBN
cord-017764-h1w9gbxk	221	19	NS5B	NS5B	NNP
cord-017764-h1w9gbxk	221	20	RNA	RNA	NNP
cord-017764-h1w9gbxk	221	21	-	-	HYPH
cord-017764-h1w9gbxk	221	22	dependent	dependent	JJ
cord-017764-h1w9gbxk	221	23	RNA	RNA	NNP
cord-017764-h1w9gbxk	221	24	polymerase	polymerase	NN
cord-017764-h1w9gbxk	221	25	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	221	26	55	55	CD
cord-017764-h1w9gbxk	221	27	,	,	,
cord-017764-h1w9gbxk	221	28	with	with	IN
cord-017764-h1w9gbxk	221	29	and	and	CC
cord-017764-h1w9gbxk	221	30	without	without	IN
cord-017764-h1w9gbxk	221	31	53	53	CD
cord-017764-h1w9gbxk	221	32	,	,	,
cord-017764-h1w9gbxk	221	33	achieves	achieve	VBZ
cord-017764-h1w9gbxk	221	34	a	a	DT
cord-017764-h1w9gbxk	221	35	high	high	JJ
cord-017764-h1w9gbxk	221	36	cure	cure	NN
cord-017764-h1w9gbxk	221	37	rate	rate	NN
cord-017764-h1w9gbxk	221	38	across	across	IN
cord-017764-h1w9gbxk	221	39	HCV	HCV	NNP
cord-017764-h1w9gbxk	221	40	genotypes	genotype	NNS
cord-017764-h1w9gbxk	221	41	and	and	CC
cord-017764-h1w9gbxk	221	42	patient	patient	JJ
cord-017764-h1w9gbxk	221	43	population	population	NN
cord-017764-h1w9gbxk	221	44	groups	group	NNS
cord-017764-h1w9gbxk	221	45	,	,	,
cord-017764-h1w9gbxk	221	46	including	include	VBG
cord-017764-h1w9gbxk	221	47	in	in	IN
cord-017764-h1w9gbxk	221	48	those	those	DT
cord-017764-h1w9gbxk	221	49	with	with	IN
cord-017764-h1w9gbxk	221	50	comorbidities	comorbiditie	NNS
cord-017764-h1w9gbxk	221	51	such	such	JJ
cord-017764-h1w9gbxk	221	52	as	as	IN
cord-017764-h1w9gbxk	221	53	HIV-1	HIV-1	NNP
cord-017764-h1w9gbxk	221	54	infection	infection	NN
cord-017764-h1w9gbxk	221	55	[	[	-LRB-
cord-017764-h1w9gbxk	221	56	127	127	CD
cord-017764-h1w9gbxk	221	57	]	]	-RRB-
cord-017764-h1w9gbxk	221	58	[	[	-LRB-
cord-017764-h1w9gbxk	221	59	128	128	CD
cord-017764-h1w9gbxk	221	60	]	]	-RRB-
cord-017764-h1w9gbxk	221	61	[	[	-LRB-
cord-017764-h1w9gbxk	221	62	129	129	CD
cord-017764-h1w9gbxk	221	63	]	]	-RRB-
cord-017764-h1w9gbxk	221	64	.	.	.
cord-017764-h1w9gbxk	222	1	In	in	IN
cord-017764-h1w9gbxk	222	2	a	a	DT
cord-017764-h1w9gbxk	222	3	compassionate	compassionate	JJ
cord-017764-h1w9gbxk	222	4	use	use	NN
cord-017764-h1w9gbxk	222	5	program	program	NN
cord-017764-h1w9gbxk	222	6	that	that	WDT
cord-017764-h1w9gbxk	222	7	reflected	reflect	VBD
cord-017764-h1w9gbxk	222	8	a	a	DT
cord-017764-h1w9gbxk	222	9	real	real	JJ
cord-017764-h1w9gbxk	222	10	-	-	HYPH
cord-017764-h1w9gbxk	222	11	world	world	NN
cord-017764-h1w9gbxk	222	12	experience	experience	NN
cord-017764-h1w9gbxk	222	13	,	,	,
cord-017764-h1w9gbxk	222	14	including	include	VBG
cord-017764-h1w9gbxk	222	15	some	some	DT
cord-017764-h1w9gbxk	222	16	subjects	subject	NNS
cord-017764-h1w9gbxk	222	17	with	with	IN
cord-017764-h1w9gbxk	222	18	advanced	advanced	JJ
cord-017764-h1w9gbxk	222	19	liver	liver	NN
cord-017764-h1w9gbxk	222	20	disease	disease	NN
cord-017764-h1w9gbxk	222	21	that	that	WDT
cord-017764-h1w9gbxk	222	22	would	would	MD
cord-017764-h1w9gbxk	222	23	have	have	VB
cord-017764-h1w9gbxk	222	24	been	be	VBN
cord-017764-h1w9gbxk	222	25	excluded	exclude	VBN
cord-017764-h1w9gbxk	222	26	from	from	IN
cord-017764-h1w9gbxk	222	27	phase	phase	NN
cord-017764-h1w9gbxk	222	28	III	iii	CD
cord-017764-h1w9gbxk	222	29	studies	study	NNS
cord-017764-h1w9gbxk	222	30	,	,	,
cord-017764-h1w9gbxk	222	31	the	the	DT
cord-017764-h1w9gbxk	222	32	combination	combination	NN
cord-017764-h1w9gbxk	222	33	of	of	IN
cord-017764-h1w9gbxk	222	34	1	1	CD
cord-017764-h1w9gbxk	222	35	and	and	CC
cord-017764-h1w9gbxk	222	36	55	55	CD
cord-017764-h1w9gbxk	222	37	(	(	-LRB-
cord-017764-h1w9gbxk	222	38	with	with	IN
cord-017764-h1w9gbxk	222	39	and	and	CC
cord-017764-h1w9gbxk	222	40	without	without	IN
cord-017764-h1w9gbxk	222	41	53	53	CD
cord-017764-h1w9gbxk	222	42	)	)	-RRB-
cord-017764-h1w9gbxk	222	43	demonstrated	demonstrate	VBD
cord-017764-h1w9gbxk	222	44	a	a	DT
cord-017764-h1w9gbxk	222	45	high	high	JJ
cord-017764-h1w9gbxk	222	46	efficacy	efficacy	NN
cord-017764-h1w9gbxk	222	47	[	[	-LRB-
cord-017764-h1w9gbxk	222	48	130	130	CD
cord-017764-h1w9gbxk	222	49	]	]	-RRB-
cord-017764-h1w9gbxk	222	50	.	.	.
cord-017764-h1w9gbxk	223	1	In	in	IN
cord-017764-h1w9gbxk	223	2	addition	addition	NN
cord-017764-h1w9gbxk	223	3	,	,	,
cord-017764-h1w9gbxk	223	4	long	long	JJ
cord-017764-h1w9gbxk	223	5	-	-	HYPH
cord-017764-h1w9gbxk	223	6	term	term	NN
cord-017764-h1w9gbxk	223	7	follow	follow	NN
cord-017764-h1w9gbxk	223	8	-	-	HYPH
cord-017764-h1w9gbxk	223	9	up	up	NN
cord-017764-h1w9gbxk	223	10	studies	study	NNS
cord-017764-h1w9gbxk	223	11	have	have	VBP
cord-017764-h1w9gbxk	223	12	demonstrated	demonstrate	VBN
cord-017764-h1w9gbxk	223	13	a	a	DT
cord-017764-h1w9gbxk	223	14	99	99	CD
cord-017764-h1w9gbxk	223	15	%	%	NN
cord-017764-h1w9gbxk	223	16	durability	durability	NN
cord-017764-h1w9gbxk	223	17	for	for	IN
cord-017764-h1w9gbxk	223	18	the	the	DT
cord-017764-h1w9gbxk	223	19	SVR	SVR	NNP
cord-017764-h1w9gbxk	223	20	12	12	CD
cord-017764-h1w9gbxk	223	21	associated	associate	VBD
cord-017764-h1w9gbxk	223	22	with	with	IN
cord-017764-h1w9gbxk	223	23	various	various	JJ
cord-017764-h1w9gbxk	223	24	regimens	regimen	NNS
cord-017764-h1w9gbxk	223	25	that	that	WDT
cord-017764-h1w9gbxk	223	26	include	include	VBP
cord-017764-h1w9gbxk	223	27	1	1	CD
cord-017764-h1w9gbxk	223	28	[	[	-LRB-
cord-017764-h1w9gbxk	223	29	131	131	CD
cord-017764-h1w9gbxk	223	30	]	]	-RRB-
cord-017764-h1w9gbxk	223	31	.	.	.
cord-017764-h1w9gbxk	224	1	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	224	2	(	(	-LRB-
cord-017764-h1w9gbxk	224	3	1	1	CD
cord-017764-h1w9gbxk	224	4	)	)	-RRB-
cord-017764-h1w9gbxk	224	5	has	have	VBZ
cord-017764-h1w9gbxk	224	6	been	be	VBN
cord-017764-h1w9gbxk	224	7	approved	approve	VBN
cord-017764-h1w9gbxk	224	8	in	in	IN
cord-017764-h1w9gbxk	224	9	more	more	JJR
cord-017764-h1w9gbxk	224	10	than	than	IN
cord-017764-h1w9gbxk	224	11	60	60	CD
cord-017764-h1w9gbxk	224	12	countries	country	NNS
cord-017764-h1w9gbxk	224	13	for	for	IN
cord-017764-h1w9gbxk	224	14	use	use	NN
cord-017764-h1w9gbxk	224	15	in	in	IN
cord-017764-h1w9gbxk	224	16	combination	combination	NN
cord-017764-h1w9gbxk	224	17	with	with	IN
cord-017764-h1w9gbxk	224	18	54	54	CD
cord-017764-h1w9gbxk	224	19	,	,	,
cord-017764-h1w9gbxk	224	20	56	56	CD
cord-017764-h1w9gbxk	224	21	,	,	,
cord-017764-h1w9gbxk	224	22	or	or	CC
cord-017764-h1w9gbxk	224	23	other	other	JJ
cord-017764-h1w9gbxk	224	24	HCV	HCV	NNP
cord-017764-h1w9gbxk	224	25	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	224	26	,	,	,
cord-017764-h1w9gbxk	224	27	including	include	VBG
cord-017764-h1w9gbxk	224	28	55	55	CD
cord-017764-h1w9gbxk	224	29	[	[	-LRB-
cord-017764-h1w9gbxk	224	30	132	132	CD
cord-017764-h1w9gbxk	224	31	]	]	-RRB-
cord-017764-h1w9gbxk	224	32	.	.	.
cord-017764-h1w9gbxk	225	1	A	a	DT
cord-017764-h1w9gbxk	225	2	combination	combination	NN
cord-017764-h1w9gbxk	225	3	of	of	IN
cord-017764-h1w9gbxk	225	4	all	all	DT
cord-017764-h1w9gbxk	225	5	four	four	CD
cord-017764-h1w9gbxk	225	6	of	of	IN
cord-017764-h1w9gbxk	225	7	these	these	DT
cord-017764-h1w9gbxk	225	8	agents	agent	NNS
cord-017764-h1w9gbxk	225	9	has	have	VBZ
cord-017764-h1w9gbxk	225	10	been	be	VBN
cord-017764-h1w9gbxk	225	11	evaluated	evaluate	VBN
cord-017764-h1w9gbxk	225	12	in	in	IN
cord-017764-h1w9gbxk	225	13	GT-1-infected	gt-1-infected	CD
cord-017764-h1w9gbxk	225	14	patients	patient	NNS
cord-017764-h1w9gbxk	225	15	as	as	IN
cord-017764-h1w9gbxk	225	16	a	a	DT
cord-017764-h1w9gbxk	225	17	drug	drug	NN
cord-017764-h1w9gbxk	225	18	intensification	intensification	NN
cord-017764-h1w9gbxk	225	19	approach	approach	NN
cord-017764-h1w9gbxk	225	20	to	to	IN
cord-017764-h1w9gbxk	225	21	shortening	shorten	VBG
cord-017764-h1w9gbxk	225	22	the	the	DT
cord-017764-h1w9gbxk	225	23	duration	duration	NN
cord-017764-h1w9gbxk	225	24	of	of	IN
cord-017764-h1w9gbxk	225	25	therapy	therapy	NN
cord-017764-h1w9gbxk	225	26	to	to	IN
cord-017764-h1w9gbxk	225	27	4	4	CD
cord-017764-h1w9gbxk	225	28	or	or	CC
cord-017764-h1w9gbxk	225	29	6	6	CD
cord-017764-h1w9gbxk	225	30	weeks	week	NNS
cord-017764-h1w9gbxk	225	31	[	[	-LRB-
cord-017764-h1w9gbxk	225	32	133	133	CD
cord-017764-h1w9gbxk	225	33	]	]	-RRB-
cord-017764-h1w9gbxk	225	34	.	.	.
cord-017764-h1w9gbxk	226	1	However	however	RB
cord-017764-h1w9gbxk	226	2	,	,	,
cord-017764-h1w9gbxk	226	3	while	while	IN
cord-017764-h1w9gbxk	226	4	the	the	DT
cord-017764-h1w9gbxk	226	5	majority	majority	NN
cord-017764-h1w9gbxk	226	6	(	(	-LRB-
cord-017764-h1w9gbxk	226	7	96	96	CD
cord-017764-h1w9gbxk	226	8	%	%	NN
cord-017764-h1w9gbxk	226	9	)	)	-RRB-
cord-017764-h1w9gbxk	226	10	of	of	IN
cord-017764-h1w9gbxk	226	11	patients	patient	NNS
cord-017764-h1w9gbxk	226	12	experienced	experience	VBD
cord-017764-h1w9gbxk	226	13	undetectable	undetectable	JJ
cord-017764-h1w9gbxk	226	14	levels	level	NNS
cord-017764-h1w9gbxk	226	15	of	of	IN
cord-017764-h1w9gbxk	226	16	HCV	HCV	NNP
cord-017764-h1w9gbxk	226	17	RNA	RNA	NNP
cord-017764-h1w9gbxk	226	18	at	at	IN
cord-017764-h1w9gbxk	226	19	the	the	DT
cord-017764-h1w9gbxk	226	20	end	end	NN
cord-017764-h1w9gbxk	226	21	of	of	IN
cord-017764-h1w9gbxk	226	22	therapy	therapy	NN
cord-017764-h1w9gbxk	226	23	,	,	,
cord-017764-h1w9gbxk	226	24	relapse	relapse	NN
cord-017764-h1w9gbxk	226	25	occurred	occur	VBD
cord-017764-h1w9gbxk	226	26	in	in	IN
cord-017764-h1w9gbxk	226	27	77	77	CD
cord-017764-h1w9gbxk	226	28	%	%	NN
cord-017764-h1w9gbxk	226	29	of	of	IN
cord-017764-h1w9gbxk	226	30	those	those	DT
cord-017764-h1w9gbxk	226	31	treated	treat	VBN
cord-017764-h1w9gbxk	226	32	for	for	IN
cord-017764-h1w9gbxk	226	33	4	4	CD
cord-017764-h1w9gbxk	226	34	weeks	week	NNS
cord-017764-h1w9gbxk	226	35	and	and	CC
cord-017764-h1w9gbxk	226	36	43	43	CD
cord-017764-h1w9gbxk	226	37	%	%	NN
cord-017764-h1w9gbxk	226	38	of	of	IN
cord-017764-h1w9gbxk	226	39	those	those	DT
cord-017764-h1w9gbxk	226	40	subject	subject	JJ
cord-017764-h1w9gbxk	226	41	to	to	IN
cord-017764-h1w9gbxk	226	42	6	6	CD
cord-017764-h1w9gbxk	226	43	weeks	week	NNS
cord-017764-h1w9gbxk	226	44	of	of	IN
cord-017764-h1w9gbxk	226	45	treatment	treatment	NN
cord-017764-h1w9gbxk	226	46	with	with	IN
cord-017764-h1w9gbxk	226	47	quadruple	quadruple	JJ
cord-017764-h1w9gbxk	226	48	therapy	therapy	NN
cord-017764-h1w9gbxk	226	49	[	[	-LRB-
cord-017764-h1w9gbxk	226	50	133	133	CD
cord-017764-h1w9gbxk	226	51	]	]	-RRB-
cord-017764-h1w9gbxk	226	52	.	.	.
cord-017764-h1w9gbxk	227	1	The	the	DT
cord-017764-h1w9gbxk	227	2	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	227	3	replication	replication	NN
cord-017764-h1w9gbxk	227	4	complex	complex	JJ
cord-017764-h1w9gbxk	227	5	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	227	6	class	class	NN
cord-017764-h1w9gbxk	227	7	of	of	IN
cord-017764-h1w9gbxk	227	8	HCV	HCV	NNP
cord-017764-h1w9gbxk	227	9	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	227	10	has	have	VBZ
cord-017764-h1w9gbxk	227	11	become	become	VBN
cord-017764-h1w9gbxk	227	12	established	establish	VBN
cord-017764-h1w9gbxk	227	13	as	as	IN
cord-017764-h1w9gbxk	227	14	a	a	DT
cord-017764-h1w9gbxk	227	15	critical	critical	JJ
cord-017764-h1w9gbxk	227	16	component	component	NN
cord-017764-h1w9gbxk	227	17	of	of	IN
cord-017764-h1w9gbxk	227	18	all	all	DT
cord-017764-h1w9gbxk	227	19	of	of	IN
cord-017764-h1w9gbxk	227	20	approved	approve	VBN
cord-017764-h1w9gbxk	227	21	pan	pan	JJ
cord-017764-h1w9gbxk	227	22	-	-	HYPH
cord-017764-h1w9gbxk	227	23	genotypic	genotypic	JJ
cord-017764-h1w9gbxk	227	24	DAA	DAA	NNP
cord-017764-h1w9gbxk	227	25	combination	combination	NN
cord-017764-h1w9gbxk	227	26	therapies	therapy	NNS
cord-017764-h1w9gbxk	227	27	[	[	-LRB-
cord-017764-h1w9gbxk	227	28	132	132	CD
cord-017764-h1w9gbxk	227	29	]	]	-RRB-
cord-017764-h1w9gbxk	227	30	.	.	.
cord-017764-h1w9gbxk	228	1	The	the	DT
cord-017764-h1w9gbxk	228	2	discovery	discovery	NN
cord-017764-h1w9gbxk	228	3	of	of	IN
cord-017764-h1w9gbxk	228	4	1	1	CD
cord-017764-h1w9gbxk	228	5	,	,	,
cord-017764-h1w9gbxk	228	6	the	the	DT
cord-017764-h1w9gbxk	228	7	prototype	prototype	NN
cord-017764-h1w9gbxk	228	8	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	228	9	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	228	10	that	that	WDT
cord-017764-h1w9gbxk	228	11	is	be	VBZ
cord-017764-h1w9gbxk	228	12	the	the	DT
cord-017764-h1w9gbxk	228	13	founding	found	VBG
cord-017764-h1w9gbxk	228	14	member	member	NN
cord-017764-h1w9gbxk	228	15	of	of	IN
cord-017764-h1w9gbxk	228	16	the	the	DT
cord-017764-h1w9gbxk	228	17	class	class	NN
cord-017764-h1w9gbxk	228	18	,	,	,
cord-017764-h1w9gbxk	228	19	was	be	VBD
cord-017764-h1w9gbxk	228	20	identified	identify	VBN
cord-017764-h1w9gbxk	228	21	only	only	RB
cord-017764-h1w9gbxk	228	22	after	after	IN
cord-017764-h1w9gbxk	228	23	considerable	considerable	JJ
cord-017764-h1w9gbxk	228	24	optimization	optimization	NN
cord-017764-h1w9gbxk	228	25	of	of	IN
cord-017764-h1w9gbxk	228	26	a	a	DT
cord-017764-h1w9gbxk	228	27	lead	lead	NN
cord-017764-h1w9gbxk	228	28	discovered	discover	VBN
cord-017764-h1w9gbxk	228	29	by	by	IN
cord-017764-h1w9gbxk	228	30	phenotypic	phenotypic	JJ
cord-017764-h1w9gbxk	228	31	screening	screening	NN
cord-017764-h1w9gbxk	228	32	,	,	,
cord-017764-h1w9gbxk	228	33	a	a	DT
cord-017764-h1w9gbxk	228	34	powerful	powerful	JJ
cord-017764-h1w9gbxk	228	35	approach	approach	NN
cord-017764-h1w9gbxk	228	36	to	to	IN
cord-017764-h1w9gbxk	228	37	drug	drug	NN
cord-017764-h1w9gbxk	228	38	discovery	discovery	NN
cord-017764-h1w9gbxk	228	39	that	that	WDT
cord-017764-h1w9gbxk	228	40	has	have	VBZ
cord-017764-h1w9gbxk	228	41	proven	prove	VBN
cord-017764-h1w9gbxk	228	42	to	to	TO
cord-017764-h1w9gbxk	228	43	be	be	VB
cord-017764-h1w9gbxk	228	44	well	well	RB
cord-017764-h1w9gbxk	228	45	-	-	HYPH
cord-017764-h1w9gbxk	228	46	suited	suit	VBN
cord-017764-h1w9gbxk	228	47	as	as	IN
cord-017764-h1w9gbxk	228	48	a	a	DT
cord-017764-h1w9gbxk	228	49	means	means	NN
cord-017764-h1w9gbxk	228	50	of	of	IN
cord-017764-h1w9gbxk	228	51	identifying	identify	VBG
cord-017764-h1w9gbxk	228	52	mechanistically	mechanistically	RB
cord-017764-h1w9gbxk	228	53	novel	novel	JJ
cord-017764-h1w9gbxk	228	54	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	228	55	agents	agent	NNS
cord-017764-h1w9gbxk	228	56	[	[	-LRB-
cord-017764-h1w9gbxk	228	57	134	134	CD
cord-017764-h1w9gbxk	228	58	]	]	-RRB-
cord-017764-h1w9gbxk	229	1	[	[	-LRB-
cord-017764-h1w9gbxk	229	2	135	135	CD
cord-017764-h1w9gbxk	229	3	]	]	-RRB-
cord-017764-h1w9gbxk	229	4	[	[	-LRB-
cord-017764-h1w9gbxk	229	5	136	136	CD
cord-017764-h1w9gbxk	229	6	]	]	-RRB-
cord-017764-h1w9gbxk	230	1	[	[	-LRB-
cord-017764-h1w9gbxk	230	2	137	137	CD
cord-017764-h1w9gbxk	230	3	]	]	-RRB-
cord-017764-h1w9gbxk	231	1	[	[	-LRB-
cord-017764-h1w9gbxk	231	2	138	138	CD
cord-017764-h1w9gbxk	231	3	]	]	-RRB-
cord-017764-h1w9gbxk	231	4	.	.	.
cord-017764-h1w9gbxk	232	1	Conflict	conflict	NN
cord-017764-h1w9gbxk	232	2	of	of	IN
cord-017764-h1w9gbxk	232	3	Interest	interest	NN
cord-017764-h1w9gbxk	233	1	The	the	DT
cord-017764-h1w9gbxk	233	2	authors	author	NNS
cord-017764-h1w9gbxk	233	3	are	be	VBP
cord-017764-h1w9gbxk	233	4	employees	employee	NNS
cord-017764-h1w9gbxk	233	5	of	of	IN
cord-017764-h1w9gbxk	233	6	Bristol	Bristol	NNP
cord-017764-h1w9gbxk	233	7	-	-	HYPH
cord-017764-h1w9gbxk	233	8	Myers	Myers	NNP
cord-017764-h1w9gbxk	233	9	Squibb	Squibb	NNP
cord-017764-h1w9gbxk	233	10	and	and	CC
cord-017764-h1w9gbxk	233	11	own	own	JJ
cord-017764-h1w9gbxk	233	12	company	company	NN
cord-017764-h1w9gbxk	233	13	stock	stock	NN
cord-017764-h1w9gbxk	233	14	.	.	.
cord-017764-h1w9gbxk	234	1	Ethical	Ethical	NNP
cord-017764-h1w9gbxk	234	2	Approval	Approval	NNP
cord-017764-h1w9gbxk	235	1	This	this	DT
cord-017764-h1w9gbxk	235	2	article	article	NN
cord-017764-h1w9gbxk	235	3	does	do	VBZ
cord-017764-h1w9gbxk	235	4	not	not	RB
cord-017764-h1w9gbxk	235	5	contain	contain	VB
cord-017764-h1w9gbxk	235	6	any	any	DT
cord-017764-h1w9gbxk	235	7	studies	study	NNS
cord-017764-h1w9gbxk	235	8	with	with	IN
cord-017764-h1w9gbxk	235	9	human	human	JJ
cord-017764-h1w9gbxk	235	10	participants	participant	NNS
cord-017764-h1w9gbxk	235	11	or	or	CC
cord-017764-h1w9gbxk	235	12	animals	animal	NNS
cord-017764-h1w9gbxk	235	13	performed	perform	VBN
cord-017764-h1w9gbxk	235	14	by	by	IN
cord-017764-h1w9gbxk	235	15	any	any	DT
cord-017764-h1w9gbxk	235	16	of	of	IN
cord-017764-h1w9gbxk	235	17	the	the	DT
cord-017764-h1w9gbxk	235	18	authors	author	NNS
cord-017764-h1w9gbxk	235	19	.	.	.
cord-017764-h1w9gbxk	236	1	Discovery	discovery	NN
cord-017764-h1w9gbxk	236	2	of	of	IN
cord-017764-h1w9gbxk	236	3	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	236	4	,	,	,
cord-017764-h1w9gbxk	236	5	a	a	DT
cord-017764-h1w9gbxk	236	6	pan	pan	JJ
cord-017764-h1w9gbxk	236	7	-	-	JJ
cord-017764-h1w9gbxk	236	8	genotypic	genotypic	JJ
cord-017764-h1w9gbxk	236	9	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	236	10	C	c	NN
cord-017764-h1w9gbxk	236	11	virus	virus	NN
cord-017764-h1w9gbxk	236	12	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	236	13	replication	replication	VBP
cord-017764-h1w9gbxk	236	14	complex	complex	JJ
cord-017764-h1w9gbxk	236	15	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	236	16	with	with	IN
cord-017764-h1w9gbxk	236	17	potent	potent	JJ
cord-017764-h1w9gbxk	236	18	clinical	clinical	JJ
cord-017764-h1w9gbxk	236	19	effect	effect	NN
cord-017764-h1w9gbxk	236	20	Case	case	NN
cord-017764-h1w9gbxk	236	21	history	history	NN
cord-017764-h1w9gbxk	236	22	:	:	:
cord-017764-h1w9gbxk	236	23	the	the	DT
cord-017764-h1w9gbxk	236	24	discovery	discovery	NN
cord-017764-h1w9gbxk	236	25	of	of	IN
cord-017764-h1w9gbxk	236	26	the	the	DT
cord-017764-h1w9gbxk	236	27	first	first	JJ
cord-017764-h1w9gbxk	236	28	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	236	29	C	c	NN
cord-017764-h1w9gbxk	236	30	virus	virus	NN
cord-017764-h1w9gbxk	236	31	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	237	1	replication	replication	NN
cord-017764-h1w9gbxk	237	2	complex	complex	JJ
cord-017764-h1w9gbxk	237	3	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	237	4	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	238	1	(	(	-LRB-
cord-017764-h1w9gbxk	238	2	Daklinza	Daklinza	NNP
cord-017764-h1w9gbxk	238	3	™	™	CD
cord-017764-h1w9gbxk	238	4	)	)	-RRB-
cord-017764-h1w9gbxk	238	5	Chemical	chemical	NN
cord-017764-h1w9gbxk	238	6	genetics	genetics	NN
cord-017764-h1w9gbxk	238	7	strategy	strategy	NN
cord-017764-h1w9gbxk	238	8	identifies	identify	VBZ
cord-017764-h1w9gbxk	238	9	an	an	DT
cord-017764-h1w9gbxk	238	10	HCV	HCV	NNP
cord-017764-h1w9gbxk	239	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	239	2	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	239	3	with	with	IN
cord-017764-h1w9gbxk	239	4	a	a	DT
cord-017764-h1w9gbxk	239	5	potent	potent	JJ
cord-017764-h1w9gbxk	239	6	clinical	clinical	JJ
cord-017764-h1w9gbxk	239	7	effect	effect	NN
cord-017764-h1w9gbxk	239	8	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	239	9	C	C	NNP
cord-017764-h1w9gbxk	239	10	virus	virus	NN
cord-017764-h1w9gbxk	239	11	NS5A	ns5a	XX
cord-017764-h1w9gbxk	240	1	replication	replication	NN
cord-017764-h1w9gbxk	240	2	complex	complex	NNP
cord-017764-h1w9gbxk	240	3	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	240	4	:	:	:
cord-017764-h1w9gbxk	240	5	the	the	DT
cord-017764-h1w9gbxk	240	6	discovery	discovery	NN
cord-017764-h1w9gbxk	240	7	of	of	IN
cord-017764-h1w9gbxk	240	8	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	241	1	The	the	DT
cord-017764-h1w9gbxk	241	2	discovery	discovery	NN
cord-017764-h1w9gbxk	241	3	and	and	CC
cord-017764-h1w9gbxk	241	4	development	development	NN
cord-017764-h1w9gbxk	241	5	of	of	IN
cord-017764-h1w9gbxk	241	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	241	7	C	C	NNP
cord-017764-h1w9gbxk	241	8	virus	virus	NN
cord-017764-h1w9gbxk	242	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	243	1	replication	replication	NN
cord-017764-h1w9gbxk	243	2	complex	complex	JJ
cord-017764-h1w9gbxk	243	3	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	243	4	Development	Development	NNP
cord-017764-h1w9gbxk	243	5	of	of	IN
cord-017764-h1w9gbxk	243	6	a	a	DT
cord-017764-h1w9gbxk	243	7	cell	cell	NN
cord-017764-h1w9gbxk	243	8	-	-	HYPH
cord-017764-h1w9gbxk	243	9	based	base	VBN
cord-017764-h1w9gbxk	243	10	high	high	JJ
cord-017764-h1w9gbxk	243	11	-	-	HYPH
cord-017764-h1w9gbxk	243	12	throughput	throughput	NN
cord-017764-h1w9gbxk	243	13	specificity	specificity	NN
cord-017764-h1w9gbxk	243	14	screen	screen	NN
cord-017764-h1w9gbxk	243	15	using	use	VBG
cord-017764-h1w9gbxk	243	16	a	a	DT
cord-017764-h1w9gbxk	243	17	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	243	18	C	c	NN
cord-017764-h1w9gbxk	243	19	virusbovine	virusbovine	NN
cord-017764-h1w9gbxk	243	20	viral	viral	JJ
cord-017764-h1w9gbxk	243	21	diarrhea	diarrhea	NN
cord-017764-h1w9gbxk	243	22	virus	virus	NN
cord-017764-h1w9gbxk	243	23	dual	dual	JJ
cord-017764-h1w9gbxk	243	24	replicon	replicon	NN
cord-017764-h1w9gbxk	243	25	assay	assay	NN
cord-017764-h1w9gbxk	243	26	Replication	Replication	NNP
cord-017764-h1w9gbxk	243	27	of	of	IN
cord-017764-h1w9gbxk	243	28	subgenomic	subgenomic	NNP
cord-017764-h1w9gbxk	243	29	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	243	30	C	C	NNP
cord-017764-h1w9gbxk	243	31	virus	virus	NN
cord-017764-h1w9gbxk	243	32	RNAs	rna	NNS
cord-017764-h1w9gbxk	243	33	in	in	IN
cord-017764-h1w9gbxk	243	34	a	a	DT
cord-017764-h1w9gbxk	243	35	hepatoma	hepatoma	NNP
cord-017764-h1w9gbxk	243	36	cell	cell	NN
cord-017764-h1w9gbxk	243	37	line	line	NN
cord-017764-h1w9gbxk	243	38	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	243	39	C	C	NNP
cord-017764-h1w9gbxk	243	40	virus	virus	NN
cord-017764-h1w9gbxk	243	41	replicons	replicon	NNS
cord-017764-h1w9gbxk	243	42	:	:	:
cord-017764-h1w9gbxk	243	43	potential	potential	JJ
cord-017764-h1w9gbxk	243	44	role	role	NN
cord-017764-h1w9gbxk	243	45	for	for	IN
cord-017764-h1w9gbxk	243	46	drug	drug	NN
cord-017764-h1w9gbxk	243	47	development	development	NN
cord-017764-h1w9gbxk	244	1	The	the	DT
cord-017764-h1w9gbxk	244	2	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	244	3	C	C	NNP
cord-017764-h1w9gbxk	244	4	virus	virus	NN
cord-017764-h1w9gbxk	244	5	replicon	replicon	NN
cord-017764-h1w9gbxk	244	6	system	system	NN
cord-017764-h1w9gbxk	244	7	:	:	:
cord-017764-h1w9gbxk	244	8	from	from	IN
cord-017764-h1w9gbxk	244	9	basic	basic	JJ
cord-017764-h1w9gbxk	244	10	research	research	NN
cord-017764-h1w9gbxk	244	11	to	to	IN
cord-017764-h1w9gbxk	244	12	clinical	clinical	JJ
cord-017764-h1w9gbxk	244	13	application	application	NN
cord-017764-h1w9gbxk	244	14	Evolution	evolution	NN
cord-017764-h1w9gbxk	244	15	of	of	IN
cord-017764-h1w9gbxk	244	16	cell	cell	NN
cord-017764-h1w9gbxk	244	17	culture	culture	NN
cord-017764-h1w9gbxk	244	18	systems	system	NNS
cord-017764-h1w9gbxk	244	19	for	for	IN
cord-017764-h1w9gbxk	244	20	HCV	HCV	NNP
cord-017764-h1w9gbxk	245	1	On	on	IN
cord-017764-h1w9gbxk	245	2	the	the	DT
cord-017764-h1w9gbxk	245	3	history	history	NN
cord-017764-h1w9gbxk	245	4	of	of	IN
cord-017764-h1w9gbxk	245	5	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	245	6	C	C	NNP
cord-017764-h1w9gbxk	245	7	virus	virus	NN
cord-017764-h1w9gbxk	245	8	cell	cell	NN
cord-017764-h1w9gbxk	245	9	culture	culture	NN
cord-017764-h1w9gbxk	245	10	systems	system	NNS
cord-017764-h1w9gbxk	245	11	Identification	identification	NN
cord-017764-h1w9gbxk	245	12	of	of	IN
cord-017764-h1w9gbxk	245	13	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	245	14	C	C	NNP
cord-017764-h1w9gbxk	245	15	virus	virus	NN
cord-017764-h1w9gbxk	246	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	247	1	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	247	2	4-Thiazolidinone	4-thiazolidinone	CD
cord-017764-h1w9gbxk	247	3	-A	-A	NNS
cord-017764-h1w9gbxk	247	4	biologically	biologically	RB
cord-017764-h1w9gbxk	247	5	active	active	JJ
cord-017764-h1w9gbxk	247	6	scaffold	scaffold	NN
cord-017764-h1w9gbxk	248	1	Convenient	convenient	JJ
cord-017764-h1w9gbxk	248	2	synthesis	synthesis	NN
cord-017764-h1w9gbxk	248	3	of	of	IN
cord-017764-h1w9gbxk	248	4	5-arylidene-2-imino-4-thiazolidinone	5-arylidene-2-imino-4-thiazolidinone	CD
cord-017764-h1w9gbxk	248	5	derivatives	derivative	NNS
cord-017764-h1w9gbxk	248	6	using	use	VBG
cord-017764-h1w9gbxk	248	7	microwave	microwave	NN
cord-017764-h1w9gbxk	248	8	irradiation	irradiation	NN
cord-017764-h1w9gbxk	248	9	Inhibitors	Inhibitors	NNP
cord-017764-h1w9gbxk	248	10	of	of	IN
cord-017764-h1w9gbxk	248	11	HCV	HCV	NNP
cord-017764-h1w9gbxk	249	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	249	2	:	:	:
cord-017764-h1w9gbxk	250	1	from	from	IN
cord-017764-h1w9gbxk	250	2	iminothiazolidinones	iminothiazolidinone	NNS
cord-017764-h1w9gbxk	250	3	to	to	IN
cord-017764-h1w9gbxk	250	4	symmetrical	symmetrical	JJ
cord-017764-h1w9gbxk	250	5	stilbenes	stilbene	NNS
cord-017764-h1w9gbxk	250	6	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	250	7	C	C	NNP
cord-017764-h1w9gbxk	250	8	virus	virus	NN
cord-017764-h1w9gbxk	250	9	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	250	10	:	:	:
cord-017764-h1w9gbxk	251	1	tales	tale	NNS
cord-017764-h1w9gbxk	251	2	of	of	IN
cord-017764-h1w9gbxk	251	3	a	a	DT
cord-017764-h1w9gbxk	251	4	promiscuous	promiscuous	JJ
cord-017764-h1w9gbxk	251	5	protein	protein	NN
cord-017764-h1w9gbxk	251	6	The	the	DT
cord-017764-h1w9gbxk	251	7	non	non	JJ
cord-017764-h1w9gbxk	251	8	-	-	JJ
cord-017764-h1w9gbxk	251	9	structural	structural	JJ
cord-017764-h1w9gbxk	251	10	5A	5a	NN
cord-017764-h1w9gbxk	251	11	protein	protein	NN
cord-017764-h1w9gbxk	251	12	of	of	IN
cord-017764-h1w9gbxk	251	13	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	251	14	C	C	NNP
cord-017764-h1w9gbxk	251	15	virus	virus	NN
cord-017764-h1w9gbxk	251	16	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	251	17	C	C	NNP
cord-017764-h1w9gbxk	251	18	virus	virus	NN
cord-017764-h1w9gbxk	252	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	252	2	:	:	:
cord-017764-h1w9gbxk	253	1	enigmatic	enigmatic	JJ
cord-017764-h1w9gbxk	253	2	but	but	CC
cord-017764-h1w9gbxk	253	3	still	still	RB
cord-017764-h1w9gbxk	253	4	promiscuous	promiscuous	JJ
cord-017764-h1w9gbxk	253	5	10	10	CD
cord-017764-h1w9gbxk	253	6	years	year	NNS
cord-017764-h1w9gbxk	253	7	on	on	RB
cord-017764-h1w9gbxk	253	8	!	!	.
cord-017764-h1w9gbxk	254	1	Biochemical	biochemical	JJ
cord-017764-h1w9gbxk	254	2	and	and	CC
cord-017764-h1w9gbxk	254	3	immunologic	immunologic	JJ
cord-017764-h1w9gbxk	254	4	properties	property	NNS
cord-017764-h1w9gbxk	254	5	of	of	IN
cord-017764-h1w9gbxk	254	6	the	the	DT
cord-017764-h1w9gbxk	254	7	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	254	8	proteins	protein	NNS
cord-017764-h1w9gbxk	254	9	of	of	IN
cord-017764-h1w9gbxk	254	10	the	the	DT
cord-017764-h1w9gbxk	254	11	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	254	12	C	C	NNP
cord-017764-h1w9gbxk	254	13	virus	virus	NN
cord-017764-h1w9gbxk	254	14	:	:	:
cord-017764-h1w9gbxk	254	15	implications	implication	NNS
cord-017764-h1w9gbxk	254	16	for	for	IN
cord-017764-h1w9gbxk	254	17	development	development	NN
cord-017764-h1w9gbxk	254	18	of	of	IN
cord-017764-h1w9gbxk	254	19	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	254	20	agents	agent	NNS
cord-017764-h1w9gbxk	254	21	and	and	CC
cord-017764-h1w9gbxk	254	22	vaccines	vaccine	NNS
cord-017764-h1w9gbxk	254	23	Mutations	mutation	NNS
cord-017764-h1w9gbxk	255	1	that	that	DT
cord-017764-h1w9gbxk	255	2	permit	permit	VBP
cord-017764-h1w9gbxk	255	3	efficient	efficient	JJ
cord-017764-h1w9gbxk	255	4	replication	replication	NN
cord-017764-h1w9gbxk	255	5	of	of	IN
cord-017764-h1w9gbxk	255	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	255	7	C	C	NNP
cord-017764-h1w9gbxk	255	8	virus	virus	NN
cord-017764-h1w9gbxk	255	9	RNA	RNA	NNP
cord-017764-h1w9gbxk	255	10	in	in	IN
cord-017764-h1w9gbxk	255	11	Huh-7	Huh-7	NNP
cord-017764-h1w9gbxk	255	12	cells	cell	NNS
cord-017764-h1w9gbxk	256	1	prevent	prevent	VB
cord-017764-h1w9gbxk	256	2	productive	productive	JJ
cord-017764-h1w9gbxk	256	3	replication	replication	NN
cord-017764-h1w9gbxk	256	4	in	in	IN
cord-017764-h1w9gbxk	256	5	chimpanzees	chimpanzee	NNS
cord-017764-h1w9gbxk	257	1	Regioselective	Regioselective	NNP
cord-017764-h1w9gbxk	257	2	synthesis	synthesis	NN
cord-017764-h1w9gbxk	257	3	of	of	IN
cord-017764-h1w9gbxk	257	4	3-(heteroaryl)-iminothiazolindin-4-ones	3-(heteroaryl)-iminothiazolindin-4-ones	CD
cord-017764-h1w9gbxk	258	1	The	the	DT
cord-017764-h1w9gbxk	258	2	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	258	3	and	and	CC
cord-017764-h1w9gbxk	258	4	Development	Development	NNP
cord-017764-h1w9gbxk	258	5	of	of	IN
cord-017764-h1w9gbxk	258	6	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	258	7	:	:	:
cord-017764-h1w9gbxk	259	1	An	an	DT
cord-017764-h1w9gbxk	259	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	259	3	of	of	IN
cord-017764-h1w9gbxk	259	4	the	the	DT
cord-017764-h1w9gbxk	259	5	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	259	6	of	of	IN
cord-017764-h1w9gbxk	259	7	potent	potent	JJ
cord-017764-h1w9gbxk	259	8	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	259	9	C	c	NN
cord-017764-h1w9gbxk	259	10	virus	virus	NN
cord-017764-h1w9gbxk	260	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	261	1	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	261	2	with	with	IN
cord-017764-h1w9gbxk	261	3	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	261	4	structures	structure	NNS
cord-017764-h1w9gbxk	262	1	HPLC	HPLC	NNP
cord-017764-h1w9gbxk	262	2	biogram	biogram	NNP
cord-017764-h1w9gbxk	262	3	analysis	analysis	NN
cord-017764-h1w9gbxk	262	4	:	:	:
cord-017764-h1w9gbxk	262	5	a	a	DT
cord-017764-h1w9gbxk	262	6	powerful	powerful	JJ
cord-017764-h1w9gbxk	262	7	tool	tool	NN
cord-017764-h1w9gbxk	262	8	used	use	VBN
cord-017764-h1w9gbxk	262	9	for	for	IN
cord-017764-h1w9gbxk	262	10	hit	hit	VB
cord-017764-h1w9gbxk	262	11	confirmation	confirmation	NN
cord-017764-h1w9gbxk	262	12	in	in	IN
cord-017764-h1w9gbxk	262	13	early	early	JJ
cord-017764-h1w9gbxk	262	14	drug	drug	NN
cord-017764-h1w9gbxk	262	15	discovery	discovery	NN
cord-017764-h1w9gbxk	263	1	The	the	DT
cord-017764-h1w9gbxk	263	2	captodative	captodative	JJ
cord-017764-h1w9gbxk	263	3	effect	effect	NN
cord-017764-h1w9gbxk	263	4	Advances	advance	VBZ
cord-017764-h1w9gbxk	263	5	in	in	IN
cord-017764-h1w9gbxk	263	6	radical	radical	JJ
cord-017764-h1w9gbxk	263	7	-	-	HYPH
cord-017764-h1w9gbxk	263	8	trapping	trap	VBG
cord-017764-h1w9gbxk	263	9	antioxidant	antioxidant	JJ
cord-017764-h1w9gbxk	263	10	chemistry	chemistry	NN
cord-017764-h1w9gbxk	263	11	in	in	IN
cord-017764-h1w9gbxk	263	12	the	the	DT
cord-017764-h1w9gbxk	263	13	twentyfirst	twentyfirst	NNP
cord-017764-h1w9gbxk	263	14	century	century	NN
cord-017764-h1w9gbxk	263	15	:	:	:
cord-017764-h1w9gbxk	263	16	a	a	DT
cord-017764-h1w9gbxk	263	17	kinetics	kinetic	NNS
cord-017764-h1w9gbxk	263	18	and	and	CC
cord-017764-h1w9gbxk	263	19	mechanisms	mechanism	NNS
cord-017764-h1w9gbxk	263	20	perspective	perspective	NN
cord-017764-h1w9gbxk	263	21	Structure	structure	NN
cord-017764-h1w9gbxk	263	22	of	of	IN
cord-017764-h1w9gbxk	263	23	the	the	DT
cord-017764-h1w9gbxk	263	24	zinc	zinc	NN
cord-017764-h1w9gbxk	263	25	-	-	HYPH
cord-017764-h1w9gbxk	263	26	binding	bind	VBG
cord-017764-h1w9gbxk	263	27	domain	domain	NN
cord-017764-h1w9gbxk	263	28	of	of	IN
cord-017764-h1w9gbxk	263	29	an	an	DT
cord-017764-h1w9gbxk	263	30	essential	essential	JJ
cord-017764-h1w9gbxk	263	31	component	component	NN
cord-017764-h1w9gbxk	263	32	of	of	IN
cord-017764-h1w9gbxk	263	33	the	the	DT
cord-017764-h1w9gbxk	263	34	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	263	35	C	C	NNP
cord-017764-h1w9gbxk	263	36	virus	virus	NN
cord-017764-h1w9gbxk	263	37	replicase	replicase	NNP
cord-017764-h1w9gbxk	263	38	Crystal	Crystal	NNP
cord-017764-h1w9gbxk	263	39	structure	structure	NN
cord-017764-h1w9gbxk	263	40	of	of	IN
cord-017764-h1w9gbxk	263	41	a	a	DT
cord-017764-h1w9gbxk	263	42	novel	novel	JJ
cord-017764-h1w9gbxk	263	43	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	263	44	form	form	NN
cord-017764-h1w9gbxk	263	45	of	of	IN
cord-017764-h1w9gbxk	263	46	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	263	47	domain	domain	NN
cord-017764-h1w9gbxk	264	1	I	-PRON-	PRP
cord-017764-h1w9gbxk	264	2	protein	protein	VBP
cord-017764-h1w9gbxk	264	3	from	from	IN
cord-017764-h1w9gbxk	264	4	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	264	5	C	C	NNP
cord-017764-h1w9gbxk	264	6	virus	virus	NN
cord-017764-h1w9gbxk	265	1	The	the	DT
cord-017764-h1w9gbxk	265	2	crystal	crystal	JJ
cord-017764-h1w9gbxk	265	3	structure	structure	NN
cord-017764-h1w9gbxk	265	4	of	of	IN
cord-017764-h1w9gbxk	265	5	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	265	6	domain	domain	NN
cord-017764-h1w9gbxk	265	7	1	1	CD
cord-017764-h1w9gbxk	265	8	from	from	IN
cord-017764-h1w9gbxk	265	9	genotype	genotype	NN
cord-017764-h1w9gbxk	265	10	1a	1a	NNP
cord-017764-h1w9gbxk	265	11	reveals	reveal	VBZ
cord-017764-h1w9gbxk	265	12	new	new	JJ
cord-017764-h1w9gbxk	265	13	clues	clue	NNS
cord-017764-h1w9gbxk	265	14	to	to	IN
cord-017764-h1w9gbxk	265	15	the	the	DT
cord-017764-h1w9gbxk	265	16	mechanism	mechanism	NN
cord-017764-h1w9gbxk	265	17	of	of	IN
cord-017764-h1w9gbxk	265	18	action	action	NN
cord-017764-h1w9gbxk	265	19	for	for	IN
cord-017764-h1w9gbxk	265	20	dimeric	dimeric	JJ
cord-017764-h1w9gbxk	265	21	HCV	HCV	NNP
cord-017764-h1w9gbxk	265	22	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	265	23	Correlation	Correlation	NNP
cord-017764-h1w9gbxk	265	24	between	between	IN
cord-017764-h1w9gbxk	265	25	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	265	26	dimerization	dimerization	NN
cord-017764-h1w9gbxk	265	27	and	and	CC
cord-017764-h1w9gbxk	265	28	HCV	HCV	NNP
cord-017764-h1w9gbxk	265	29	replication	replication	NN
cord-017764-h1w9gbxk	265	30	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	265	31	C	C	NNP
cord-017764-h1w9gbxk	265	32	virus	virus	NN
cord-017764-h1w9gbxk	265	33	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	265	34	protein	protein	NN
cord-017764-h1w9gbxk	265	35	5A	5a	CD
cord-017764-h1w9gbxk	266	1	(	(	-LRB-
cord-017764-h1w9gbxk	266	2	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	266	3	)	)	-RRB-
cord-017764-h1w9gbxk	266	4	is	be	VBZ
cord-017764-h1w9gbxk	266	5	an	an	DT
cord-017764-h1w9gbxk	266	6	RNA	RNA	NNP
cord-017764-h1w9gbxk	266	7	-	-	HYPH
cord-017764-h1w9gbxk	266	8	binding	bind	VBG
cord-017764-h1w9gbxk	266	9	protein	protein	NN
cord-017764-h1w9gbxk	266	10	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	266	11	C	C	NNP
cord-017764-h1w9gbxk	266	12	virus	virus	NN
cord-017764-h1w9gbxk	266	13	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	266	14	protein	protein	NN
cord-017764-h1w9gbxk	266	15	5A	5a	NN
cord-017764-h1w9gbxk	266	16	:	:	:
cord-017764-h1w9gbxk	266	17	biochemical	biochemical	JJ
cord-017764-h1w9gbxk	266	18	characterization	characterization	NN
cord-017764-h1w9gbxk	266	19	of	of	IN
cord-017764-h1w9gbxk	266	20	a	a	DT
cord-017764-h1w9gbxk	266	21	novel	novel	JJ
cord-017764-h1w9gbxk	266	22	structural	structural	JJ
cord-017764-h1w9gbxk	266	23	class	class	NN
cord-017764-h1w9gbxk	266	24	of	of	IN
cord-017764-h1w9gbxk	266	25	RNA	rna	NN
cord-017764-h1w9gbxk	266	26	-	-	HYPH
cord-017764-h1w9gbxk	266	27	binding	bind	VBG
cord-017764-h1w9gbxk	266	28	proteins	protein	NNS
cord-017764-h1w9gbxk	267	1	All	all	DT
cord-017764-h1w9gbxk	267	2	three	three	CD
cord-017764-h1w9gbxk	267	3	domains	domain	NNS
cord-017764-h1w9gbxk	267	4	of	of	IN
cord-017764-h1w9gbxk	267	5	the	the	DT
cord-017764-h1w9gbxk	267	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	267	7	C	C	NNP
cord-017764-h1w9gbxk	267	8	virus	virus	NN
cord-017764-h1w9gbxk	267	9	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	268	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	268	2	protein	protein	NN
cord-017764-h1w9gbxk	268	3	contribute	contribute	VBP
cord-017764-h1w9gbxk	268	4	to	to	IN
cord-017764-h1w9gbxk	268	5	RNA	RNA	NNP
cord-017764-h1w9gbxk	268	6	binding	bind	VBG
cord-017764-h1w9gbxk	268	7	HCV	HCV	NNP
cord-017764-h1w9gbxk	269	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	269	2	replication	replication	NN
cord-017764-h1w9gbxk	269	3	complex	complex	JJ
cord-017764-h1w9gbxk	269	4	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	269	5	.	.	.
cord-017764-h1w9gbxk	270	1	Part	part	NN
cord-017764-h1w9gbxk	270	2	3	3	CD
cord-017764-h1w9gbxk	270	3	:	:	:
cord-017764-h1w9gbxk	270	4	discovery	discovery	NN
cord-017764-h1w9gbxk	270	5	of	of	IN
cord-017764-h1w9gbxk	270	6	potent	potent	JJ
cord-017764-h1w9gbxk	270	7	analogs	analog	NNS
cord-017764-h1w9gbxk	270	8	with	with	IN
cord-017764-h1w9gbxk	270	9	distinct	distinct	JJ
cord-017764-h1w9gbxk	270	10	core	core	NN
cord-017764-h1w9gbxk	270	11	topologies	topology	NNS
cord-017764-h1w9gbxk	270	12	HCV	HCV	NNP
cord-017764-h1w9gbxk	271	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	271	2	replication	replication	NN
cord-017764-h1w9gbxk	271	3	complex	complex	JJ
cord-017764-h1w9gbxk	271	4	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	271	5	.	.	.
cord-017764-h1w9gbxk	272	1	Part	part	NN
cord-017764-h1w9gbxk	272	2	4	4	CD
cord-017764-h1w9gbxk	272	3	:	:	:
cord-017764-h1w9gbxk	272	4	optimization	optimization	NN
cord-017764-h1w9gbxk	272	5	for	for	IN
cord-017764-h1w9gbxk	272	6	genotype	genotype	NN
cord-017764-h1w9gbxk	272	7	1a	1a	CD
cord-017764-h1w9gbxk	272	8	replicon	replicon	NN
cord-017764-h1w9gbxk	272	9	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	272	10	activity	activity	NN
cord-017764-h1w9gbxk	273	1	HCV	HCV	NNP
cord-017764-h1w9gbxk	274	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	274	2	replication	replication	NN
cord-017764-h1w9gbxk	274	3	complex	complex	JJ
cord-017764-h1w9gbxk	274	4	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	274	5	.	.	.
cord-017764-h1w9gbxk	275	1	Part	part	NN
cord-017764-h1w9gbxk	275	2	5	5	CD
cord-017764-h1w9gbxk	275	3	:	:	:
cord-017764-h1w9gbxk	275	4	discovery	discovery	NN
cord-017764-h1w9gbxk	275	5	of	of	IN
cord-017764-h1w9gbxk	275	6	potent	potent	JJ
cord-017764-h1w9gbxk	275	7	and	and	CC
cord-017764-h1w9gbxk	275	8	pan	pan	JJ
cord-017764-h1w9gbxk	275	9	-	-	JJ
cord-017764-h1w9gbxk	275	10	genotypic	genotypic	JJ
cord-017764-h1w9gbxk	275	11	HCV	HCV	NNP
cord-017764-h1w9gbxk	275	12	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	275	13	replication	replication	NN
cord-017764-h1w9gbxk	275	14	complex	complex	NN
cord-017764-h1w9gbxk	275	15	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	275	16	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	275	17	C	C	NNP
cord-017764-h1w9gbxk	275	18	virus	virus	NN
cord-017764-h1w9gbxk	275	19	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	275	20	replication	replication	NN
cord-017764-h1w9gbxk	275	21	complex	complex	JJ
cord-017764-h1w9gbxk	275	22	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	275	23	.	.	.
cord-017764-h1w9gbxk	276	1	Part	part	NN
cord-017764-h1w9gbxk	276	2	6	6	CD
cord-017764-h1w9gbxk	276	3	:	:	:
cord-017764-h1w9gbxk	276	4	the	the	DT
cord-017764-h1w9gbxk	276	5	discovery	discovery	NN
cord-017764-h1w9gbxk	276	6	of	of	IN
cord-017764-h1w9gbxk	276	7	a	a	DT
cord-017764-h1w9gbxk	276	8	novel	novel	NN
cord-017764-h1w9gbxk	276	9	and	and	CC
cord-017764-h1w9gbxk	276	10	highly	highly	RB
cord-017764-h1w9gbxk	276	11	potent	potent	JJ
cord-017764-h1w9gbxk	276	12	biarylimidazole	biarylimidazole	NN
cord-017764-h1w9gbxk	276	13	chemotype	chemotype	NN
cord-017764-h1w9gbxk	276	14	with	with	IN
cord-017764-h1w9gbxk	276	15	inhibitory	inhibitory	JJ
cord-017764-h1w9gbxk	276	16	activity	activity	NN
cord-017764-h1w9gbxk	276	17	toward	toward	IN
cord-017764-h1w9gbxk	276	18	genotype	genotype	NN
cord-017764-h1w9gbxk	276	19	1a	1a	NN
cord-017764-h1w9gbxk	276	20	and	and	CC
cord-017764-h1w9gbxk	276	21	1b	1b	CD
cord-017764-h1w9gbxk	276	22	replicons	replicon	NNS
cord-017764-h1w9gbxk	276	23	Resistance	Resistance	NNP
cord-017764-h1w9gbxk	276	24	analysis	analysis	NN
cord-017764-h1w9gbxk	276	25	of	of	IN
cord-017764-h1w9gbxk	276	26	the	the	DT
cord-017764-h1w9gbxk	276	27	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	276	28	C	C	NNP
cord-017764-h1w9gbxk	276	29	virus	virus	NN
cord-017764-h1w9gbxk	277	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	278	1	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	279	1	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	279	2	in	in	IN
cord-017764-h1w9gbxk	279	3	an	an	DT
cord-017764-h1w9gbxk	279	4	in	in	FW
cord-017764-h1w9gbxk	279	5	vitro	vitro	FW
cord-017764-h1w9gbxk	279	6	replicon	replicon	NN
cord-017764-h1w9gbxk	279	7	system	system	NN
cord-017764-h1w9gbxk	280	1	vitro	vitro	FW
cord-017764-h1w9gbxk	280	2	activity	activity	NN
cord-017764-h1w9gbxk	280	3	of	of	IN
cord-017764-h1w9gbxk	280	4	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	280	5	on	on	IN
cord-017764-h1w9gbxk	280	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	280	7	C	C	NNP
cord-017764-h1w9gbxk	280	8	virus	virus	NN
cord-017764-h1w9gbxk	280	9	genotype	genotype	NN
cord-017764-h1w9gbxk	280	10	4	4	CD
cord-017764-h1w9gbxk	281	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	282	1	In	in	IN
cord-017764-h1w9gbxk	282	2	vitro	vitro	FW
cord-017764-h1w9gbxk	282	3	activity	activity	NN
cord-017764-h1w9gbxk	282	4	of	of	IN
cord-017764-h1w9gbxk	282	5	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	282	6	on	on	IN
cord-017764-h1w9gbxk	282	7	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	282	8	C	C	NNP
cord-017764-h1w9gbxk	282	9	virus	virus	NN
cord-017764-h1w9gbxk	282	10	genotype	genotype	NN
cord-017764-h1w9gbxk	282	11	3	3	CD
cord-017764-h1w9gbxk	283	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	284	1	Comparison	comparison	NN
cord-017764-h1w9gbxk	284	2	of	of	IN
cord-017764-h1w9gbxk	284	3	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	284	4	resistance	resistance	NN
cord-017764-h1w9gbxk	284	5	barriers	barrier	NNS
cord-017764-h1w9gbxk	284	6	on	on	IN
cord-017764-h1w9gbxk	284	7	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	284	8	from	from	IN
cord-017764-h1w9gbxk	284	9	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	284	10	C	C	NNP
cord-017764-h1w9gbxk	284	11	virus	virus	NN
cord-017764-h1w9gbxk	284	12	genotypes	genotype	NNS
cord-017764-h1w9gbxk	284	13	1	1	CD
cord-017764-h1w9gbxk	284	14	to	to	IN
cord-017764-h1w9gbxk	284	15	6	6	CD
cord-017764-h1w9gbxk	284	16	:	:	:
cord-017764-h1w9gbxk	284	17	implications	implication	NNS
cord-017764-h1w9gbxk	284	18	for	for	IN
cord-017764-h1w9gbxk	284	19	cross	cross	JJ
cord-017764-h1w9gbxk	284	20	-	-	JJ
cord-017764-h1w9gbxk	284	21	genotype	genotype	JJ
cord-017764-h1w9gbxk	284	22	activity	activity	NN
cord-017764-h1w9gbxk	285	1	The	the	DT
cord-017764-h1w9gbxk	285	2	discovery	discovery	NN
cord-017764-h1w9gbxk	285	3	of	of	IN
cord-017764-h1w9gbxk	285	4	potent	potent	JJ
cord-017764-h1w9gbxk	285	5	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	285	6	protein	protein	NN
cord-017764-h1w9gbxk	285	7	5A	5a	NN
cord-017764-h1w9gbxk	285	8	(	(	-LRB-
cord-017764-h1w9gbxk	285	9	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	285	10	)	)	-RRB-
cord-017764-h1w9gbxk	285	11	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	285	12	with	with	IN
cord-017764-h1w9gbxk	285	13	a	a	DT
cord-017764-h1w9gbxk	285	14	unique	unique	JJ
cord-017764-h1w9gbxk	285	15	resistance	resistance	NN
cord-017764-h1w9gbxk	285	16	profile	profile	NN
cord-017764-h1w9gbxk	285	17	-part	-part	$
cord-017764-h1w9gbxk	285	18	2	2	CD
cord-017764-h1w9gbxk	285	19	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	285	20	C	C	NNP
cord-017764-h1w9gbxk	285	21	virus	virus	NN
cord-017764-h1w9gbxk	286	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	287	1	protein	protein	NN
cord-017764-h1w9gbxk	287	2	-a	-a	HYPH
cord-017764-h1w9gbxk	287	3	master	master	NN
cord-017764-h1w9gbxk	287	4	regulator	regulator	NN
cord-017764-h1w9gbxk	287	5	ed	ed	NNP
cord-017764-h1w9gbxk	287	6	)	)	-RRB-
cord-017764-h1w9gbxk	287	7	Hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	287	8	C	c	NN
cord-017764-h1w9gbxk	287	9	viruses	virus	NNS
cord-017764-h1w9gbxk	288	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	289	1	-from	-from	JJ
cord-017764-h1w9gbxk	289	2	obscurity	obscurity	NN
cord-017764-h1w9gbxk	289	3	to	to	IN
cord-017764-h1w9gbxk	289	4	new	new	JJ
cord-017764-h1w9gbxk	289	5	target	target	NN
cord-017764-h1w9gbxk	289	6	for	for	IN
cord-017764-h1w9gbxk	289	7	HCV	HCV	NNP
cord-017764-h1w9gbxk	289	8	therapy	therapy	NN
cord-017764-h1w9gbxk	289	9	Targeting	target	VBG
cord-017764-h1w9gbxk	289	10	the	the	DT
cord-017764-h1w9gbxk	289	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	289	12	protein	protein	NN
cord-017764-h1w9gbxk	289	13	of	of	IN
cord-017764-h1w9gbxk	289	14	HCV	HCV	NNP
cord-017764-h1w9gbxk	289	15	:	:	:
cord-017764-h1w9gbxk	289	16	an	an	DT
cord-017764-h1w9gbxk	289	17	emerging	emerge	VBG
cord-017764-h1w9gbxk	289	18	option	option	NN
cord-017764-h1w9gbxk	290	1	Small	small	JJ
cord-017764-h1w9gbxk	290	2	molecule	molecule	NN
cord-017764-h1w9gbxk	290	3	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	290	4	of	of	IN
cord-017764-h1w9gbxk	290	5	the	the	DT
cord-017764-h1w9gbxk	290	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	290	7	C	C	NNP
cord-017764-h1w9gbxk	290	8	virus	virus	NN
cord-017764-h1w9gbxk	290	9	-	-	:
cord-017764-h1w9gbxk	290	10	encoded	encode	VBN
cord-017764-h1w9gbxk	290	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	290	12	protein	protein	NN
cord-017764-h1w9gbxk	290	13	NS5A	NS5A	NNS
cord-017764-h1w9gbxk	290	14	:	:	:
cord-017764-h1w9gbxk	291	1	a	a	DT
cord-017764-h1w9gbxk	291	2	new	new	JJ
cord-017764-h1w9gbxk	291	3	target	target	NN
cord-017764-h1w9gbxk	291	4	for	for	IN
cord-017764-h1w9gbxk	291	5	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	291	6	drugs	drug	NNS
cord-017764-h1w9gbxk	291	7	in	in	IN
cord-017764-h1w9gbxk	291	8	the	the	DT
cord-017764-h1w9gbxk	291	9	treatment	treatment	NN
cord-017764-h1w9gbxk	291	10	of	of	IN
cord-017764-h1w9gbxk	291	11	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	291	12	C	C	NNP
cord-017764-h1w9gbxk	291	13	virus	virus	NN
cord-017764-h1w9gbxk	291	14	infection	infection	NN
cord-017764-h1w9gbxk	291	15	HCV	HCV	NNP
cord-017764-h1w9gbxk	292	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	292	2	replication	replication	NN
cord-017764-h1w9gbxk	293	1	complex	complex	NNP
cord-017764-h1w9gbxk	293	2	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	294	1	Modeling	modeling	NN
cord-017764-h1w9gbxk	294	2	shows	show	VBZ
cord-017764-h1w9gbxk	294	3	that	that	IN
cord-017764-h1w9gbxk	294	4	the	the	DT
cord-017764-h1w9gbxk	294	5	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	294	6	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	294	7	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	294	8	has	have	VBZ
cord-017764-h1w9gbxk	294	9	two	two	CD
cord-017764-h1w9gbxk	294	10	modes	mode	NNS
cord-017764-h1w9gbxk	294	11	of	of	IN
cord-017764-h1w9gbxk	294	12	action	action	NN
cord-017764-h1w9gbxk	294	13	and	and	CC
cord-017764-h1w9gbxk	294	14	yields	yield	VBZ
cord-017764-h1w9gbxk	294	15	a	a	DT
cord-017764-h1w9gbxk	294	16	shorter	short	JJR
cord-017764-h1w9gbxk	294	17	estimate	estimate	NN
cord-017764-h1w9gbxk	294	18	of	of	IN
cord-017764-h1w9gbxk	294	19	the	the	DT
cord-017764-h1w9gbxk	294	20	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	294	21	C	C	NNP
cord-017764-h1w9gbxk	294	22	virus	virus	NN
cord-017764-h1w9gbxk	295	1	half	half	JJ
cord-017764-h1w9gbxk	295	2	-	-	HYPH
cord-017764-h1w9gbxk	295	3	life	life	NN
cord-017764-h1w9gbxk	295	4	Kinetic	kinetic	JJ
cord-017764-h1w9gbxk	295	5	analyses	analysis	NNS
cord-017764-h1w9gbxk	295	6	reveal	reveal	VBP
cord-017764-h1w9gbxk	295	7	potent	potent	JJ
cord-017764-h1w9gbxk	295	8	and	and	CC
cord-017764-h1w9gbxk	295	9	early	early	JJ
cord-017764-h1w9gbxk	295	10	blockade	blockade	NN
cord-017764-h1w9gbxk	295	11	of	of	IN
cord-017764-h1w9gbxk	295	12	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	295	13	C	C	NNP
cord-017764-h1w9gbxk	295	14	virus	virus	NN
cord-017764-h1w9gbxk	295	15	assembly	assembly	NN
cord-017764-h1w9gbxk	295	16	by	by	IN
cord-017764-h1w9gbxk	295	17	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	295	18	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	296	1	Multiple	multiple	JJ
cord-017764-h1w9gbxk	296	2	ascending	ascend	VBG
cord-017764-h1w9gbxk	296	3	dose	dose	JJ
cord-017764-h1w9gbxk	296	4	study	study	NN
cord-017764-h1w9gbxk	296	5	of	of	IN
cord-017764-h1w9gbxk	296	6	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	296	7	,	,	,
cord-017764-h1w9gbxk	296	8	a	a	DT
cord-017764-h1w9gbxk	296	9	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	296	10	protein	protein	NN
cord-017764-h1w9gbxk	296	11	5A	5a	CD
cord-017764-h1w9gbxk	296	12	replication	replication	NN
cord-017764-h1w9gbxk	296	13	complex	complex	JJ
cord-017764-h1w9gbxk	296	14	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	296	15	,	,	,
cord-017764-h1w9gbxk	296	16	in	in	IN
cord-017764-h1w9gbxk	296	17	patients	patient	NNS
cord-017764-h1w9gbxk	296	18	infected	infect	VBN
cord-017764-h1w9gbxk	296	19	with	with	IN
cord-017764-h1w9gbxk	296	20	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	296	21	C	C	NNP
cord-017764-h1w9gbxk	296	22	virus	virus	NN
cord-017764-h1w9gbxk	296	23	genotype	genotype	NN
cord-017764-h1w9gbxk	296	24	1	1	CD
cord-017764-h1w9gbxk	296	25	Interaction	Interaction	NNP
cord-017764-h1w9gbxk	296	26	between	between	IN
cord-017764-h1w9gbxk	296	27	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	296	28	C	C	NNP
cord-017764-h1w9gbxk	296	29	virus	virus	NN
cord-017764-h1w9gbxk	296	30	and	and	CC
cord-017764-h1w9gbxk	296	31	host	host	NN
cord-017764-h1w9gbxk	296	32	cell	cell	NN
cord-017764-h1w9gbxk	296	33	factors	factor	NNS
cord-017764-h1w9gbxk	297	1	HCVpro	HCVpro	NNP
cord-017764-h1w9gbxk	297	2	:	:	:
cord-017764-h1w9gbxk	297	3	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	297	4	C	C	NNP
cord-017764-h1w9gbxk	297	5	virus	virus	NN
cord-017764-h1w9gbxk	297	6	protein	protein	NN
cord-017764-h1w9gbxk	297	7	interaction	interaction	NN
cord-017764-h1w9gbxk	297	8	database	database	NN
cord-017764-h1w9gbxk	297	9	Understanding	understand	VBG
cord-017764-h1w9gbxk	297	10	the	the	DT
cord-017764-h1w9gbxk	297	11	biological	biological	JJ
cord-017764-h1w9gbxk	297	12	context	context	NN
cord-017764-h1w9gbxk	297	13	of	of	IN
cord-017764-h1w9gbxk	297	14	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	297	15	-	-	HYPH
cord-017764-h1w9gbxk	297	16	host	host	NN
cord-017764-h1w9gbxk	297	17	interactions	interaction	NNS
cord-017764-h1w9gbxk	297	18	in	in	IN
cord-017764-h1w9gbxk	297	19	HCV	HCV	NNP
cord-017764-h1w9gbxk	297	20	infection	infection	NN
cord-017764-h1w9gbxk	297	21	:	:	:
cord-017764-h1w9gbxk	297	22	a	a	DT
cord-017764-h1w9gbxk	297	23	network	network	NN
cord-017764-h1w9gbxk	297	24	-	-	HYPH
cord-017764-h1w9gbxk	297	25	based	base	VBN
cord-017764-h1w9gbxk	297	26	approach	approach	NN
cord-017764-h1w9gbxk	297	27	Affinity	Affinity	NNP
cord-017764-h1w9gbxk	297	28	capture	capture	NN
cord-017764-h1w9gbxk	297	29	and	and	CC
cord-017764-h1w9gbxk	297	30	identification	identification	NN
cord-017764-h1w9gbxk	297	31	of	of	IN
cord-017764-h1w9gbxk	297	32	host	host	NN
cord-017764-h1w9gbxk	297	33	cell	cell	NN
cord-017764-h1w9gbxk	297	34	factors	factor	NNS
cord-017764-h1w9gbxk	297	35	associated	associate	VBN
cord-017764-h1w9gbxk	297	36	with	with	IN
cord-017764-h1w9gbxk	297	37	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	297	38	C	C	NNP
cord-017764-h1w9gbxk	297	39	virus	virus	NN
cord-017764-h1w9gbxk	297	40	(	(	-LRB-
cord-017764-h1w9gbxk	297	41	+	+	CC
cord-017764-h1w9gbxk	298	1	)	)	-RRB-
cord-017764-h1w9gbxk	298	2	strand	strand	NN
cord-017764-h1w9gbxk	298	3	subgenomic	subgenomic	NNP
cord-017764-h1w9gbxk	298	4	RNA	RNA	NNP
cord-017764-h1w9gbxk	299	1	The	the	DT
cord-017764-h1w9gbxk	299	2	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	299	3	and	and	CC
cord-017764-h1w9gbxk	299	4	Development	Development	NNP
cord-017764-h1w9gbxk	299	5	of	of	IN
cord-017764-h1w9gbxk	299	6	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	299	7	:	:	:
cord-017764-h1w9gbxk	300	1	An	an	DT
cord-017764-h1w9gbxk	300	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	300	3	of	of	IN
cord-017764-h1w9gbxk	300	4	the	the	DT
cord-017764-h1w9gbxk	300	5	Identification	Identification	NNP
cord-017764-h1w9gbxk	300	6	and	and	CC
cord-017764-h1w9gbxk	300	7	comparative	comparative	JJ
cord-017764-h1w9gbxk	300	8	analysis	analysis	NN
cord-017764-h1w9gbxk	300	9	of	of	IN
cord-017764-h1w9gbxk	300	10	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	300	11	C	C	NNP
cord-017764-h1w9gbxk	300	12	virus	virus	NN
cord-017764-h1w9gbxk	300	13	-	-	HYPH
cord-017764-h1w9gbxk	300	14	host	host	NN
cord-017764-h1w9gbxk	300	15	cell	cell	NN
cord-017764-h1w9gbxk	300	16	protein	protein	NN
cord-017764-h1w9gbxk	300	17	interactions	interaction	NNS
cord-017764-h1w9gbxk	300	18	Host	Host	NNP
cord-017764-h1w9gbxk	300	19	cell	cell	NN
cord-017764-h1w9gbxk	300	20	kinases	kinase	NNS
cord-017764-h1w9gbxk	300	21	and	and	CC
cord-017764-h1w9gbxk	300	22	the	the	DT
cord-017764-h1w9gbxk	300	23	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	300	24	C	C	NNP
cord-017764-h1w9gbxk	300	25	virus	virus	NN
cord-017764-h1w9gbxk	300	26	lifecycle	lifecycle	NN
cord-017764-h1w9gbxk	300	27	Potent	Potent	NNP
cord-017764-h1w9gbxk	300	28	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	300	29	C	C	NNP
cord-017764-h1w9gbxk	300	30	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	300	31	bind	bind	VBP
cord-017764-h1w9gbxk	300	32	directly	directly	RB
cord-017764-h1w9gbxk	300	33	to	to	IN
cord-017764-h1w9gbxk	300	34	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	300	35	and	and	CC
cord-017764-h1w9gbxk	300	36	reduce	reduce	VB
cord-017764-h1w9gbxk	300	37	its	-PRON-	PRP$
cord-017764-h1w9gbxk	300	38	affinity	affinity	NN
cord-017764-h1w9gbxk	300	39	for	for	IN
cord-017764-h1w9gbxk	300	40	RNA	RNA	NNP
cord-017764-h1w9gbxk	300	41	Direct	Direct	NNP
cord-017764-h1w9gbxk	300	42	binding	binding	NN
cord-017764-h1w9gbxk	300	43	of	of	IN
cord-017764-h1w9gbxk	300	44	ledipasvir	ledipasvir	NNS
cord-017764-h1w9gbxk	300	45	to	to	IN
cord-017764-h1w9gbxk	300	46	HCV	HCV	NNP
cord-017764-h1w9gbxk	301	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	301	2	:	:	:
cord-017764-h1w9gbxk	302	1	mechanism	mechanism	NN
cord-017764-h1w9gbxk	302	2	of	of	IN
cord-017764-h1w9gbxk	302	3	resistance	resistance	NN
cord-017764-h1w9gbxk	302	4	to	to	IN
cord-017764-h1w9gbxk	302	5	an	an	DT
cord-017764-h1w9gbxk	302	6	HCV	HCV	NNP
cord-017764-h1w9gbxk	302	7	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	302	8	agent	agent	NN
cord-017764-h1w9gbxk	302	9	Resensitizing	Resensitizing	NNP
cord-017764-h1w9gbxk	302	10	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	302	11	-	-	HYPH
cord-017764-h1w9gbxk	302	12	resistance	resistance	NN
cord-017764-h1w9gbxk	302	13	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	302	14	C	c	NN
cord-017764-h1w9gbxk	302	15	variants	variant	NNS
cord-017764-h1w9gbxk	302	16	by	by	IN
cord-017764-h1w9gbxk	302	17	allosteric	allosteric	JJ
cord-017764-h1w9gbxk	302	18	modulation	modulation	NN
cord-017764-h1w9gbxk	302	19	of	of	IN
cord-017764-h1w9gbxk	302	20	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	302	21	Synergistic	synergistic	JJ
cord-017764-h1w9gbxk	302	22	activity	activity	NN
cord-017764-h1w9gbxk	302	23	of	of	IN
cord-017764-h1w9gbxk	302	24	combined	combine	VBN
cord-017764-h1w9gbxk	303	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	304	1	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	305	1	Asymmetric	asymmetric	JJ
cord-017764-h1w9gbxk	305	2	binding	binding	NN
cord-017764-h1w9gbxk	305	3	to	to	IN
cord-017764-h1w9gbxk	305	4	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	305	5	by	by	IN
cord-017764-h1w9gbxk	305	6	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	305	7	(	(	-LRB-
cord-017764-h1w9gbxk	305	8	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	305	9	)	)	-RRB-
cord-017764-h1w9gbxk	305	10	and	and	CC
cord-017764-h1w9gbxk	306	1	analogs	analog	NNS
cord-017764-h1w9gbxk	306	2	suggests	suggest	VBZ
cord-017764-h1w9gbxk	306	3	two	two	CD
cord-017764-h1w9gbxk	306	4	novel	novel	JJ
cord-017764-h1w9gbxk	306	5	modes	mode	NNS
cord-017764-h1w9gbxk	306	6	of	of	IN
cord-017764-h1w9gbxk	306	7	HCV	HCV	NNP
cord-017764-h1w9gbxk	306	8	inhibition	inhibition	NN
cord-017764-h1w9gbxk	306	9	Resistance	resistance	NN
cord-017764-h1w9gbxk	306	10	patterns	pattern	NNS
cord-017764-h1w9gbxk	306	11	associated	associate	VBN
cord-017764-h1w9gbxk	306	12	with	with	IN
cord-017764-h1w9gbxk	306	13	HCV	HCV	NNP
cord-017764-h1w9gbxk	307	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	307	2	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	307	3	provide	provide	VBP
cord-017764-h1w9gbxk	307	4	limited	limited	JJ
cord-017764-h1w9gbxk	307	5	insight	insight	NN
cord-017764-h1w9gbxk	307	6	into	into	IN
cord-017764-h1w9gbxk	307	7	drug	drug	NN
cord-017764-h1w9gbxk	307	8	binding	bind	VBG
cord-017764-h1w9gbxk	307	9	A	a	DT
cord-017764-h1w9gbxk	307	10	refined	refined	JJ
cord-017764-h1w9gbxk	307	11	model	model	NN
cord-017764-h1w9gbxk	307	12	of	of	IN
cord-017764-h1w9gbxk	307	13	the	the	DT
cord-017764-h1w9gbxk	307	14	HCV	HCV	NNP
cord-017764-h1w9gbxk	308	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	308	2	protein	protein	NN
cord-017764-h1w9gbxk	308	3	bound	bind	VBN
cord-017764-h1w9gbxk	308	4	to	to	IN
cord-017764-h1w9gbxk	308	5	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	308	6	explains	explain	VBZ
cord-017764-h1w9gbxk	308	7	drug	drug	NN
cord-017764-h1w9gbxk	308	8	-	-	HYPH
cord-017764-h1w9gbxk	308	9	resistant	resistant	JJ
cord-017764-h1w9gbxk	308	10	mutations	mutation	NNS
cord-017764-h1w9gbxk	308	11	and	and	CC
cord-017764-h1w9gbxk	308	12	activity	activity	NN
cord-017764-h1w9gbxk	308	13	against	against	IN
cord-017764-h1w9gbxk	308	14	divergent	divergent	JJ
cord-017764-h1w9gbxk	308	15	genotypes	genotype	NNS
cord-017764-h1w9gbxk	309	1	A	a	DT
cord-017764-h1w9gbxk	309	2	comprehensive	comprehensive	JJ
cord-017764-h1w9gbxk	309	3	computational	computational	JJ
cord-017764-h1w9gbxk	309	4	analysis	analysis	NN
cord-017764-h1w9gbxk	309	5	for	for	IN
cord-017764-h1w9gbxk	309	6	the	the	DT
cord-017764-h1w9gbxk	309	7	binding	bind	VBG
cord-017764-h1w9gbxk	309	8	modes	mode	NNS
cord-017764-h1w9gbxk	309	9	of	of	IN
cord-017764-h1w9gbxk	309	10	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	309	11	C	C	NNP
cord-017764-h1w9gbxk	309	12	virus	virus	NN
cord-017764-h1w9gbxk	310	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	311	1	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	311	2	:	:	:
cord-017764-h1w9gbxk	312	1	the	the	DT
cord-017764-h1w9gbxk	312	2	question	question	NN
cord-017764-h1w9gbxk	312	3	of	of	IN
cord-017764-h1w9gbxk	312	4	symmetry	symmetry	NN
cord-017764-h1w9gbxk	312	5	Overall	overall	JJ
cord-017764-h1w9gbxk	312	6	structural	structural	JJ
cord-017764-h1w9gbxk	312	7	model	model	NN
cord-017764-h1w9gbxk	312	8	of	of	IN
cord-017764-h1w9gbxk	312	9	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	312	10	protein	protein	NN
cord-017764-h1w9gbxk	312	11	from	from	IN
cord-017764-h1w9gbxk	312	12	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	312	13	C	C	NNP
cord-017764-h1w9gbxk	312	14	virus	virus	NN
cord-017764-h1w9gbxk	312	15	and	and	CC
cord-017764-h1w9gbxk	312	16	modulation	modulation	NN
cord-017764-h1w9gbxk	312	17	by	by	IN
cord-017764-h1w9gbxk	312	18	mutations	mutation	NNS
cord-017764-h1w9gbxk	312	19	conferring	confer	VBG
cord-017764-h1w9gbxk	312	20	resistance	resistance	NN
cord-017764-h1w9gbxk	312	21	of	of	IN
cord-017764-h1w9gbxk	312	22	virus	virus	NN
cord-017764-h1w9gbxk	312	23	replication	replication	NN
cord-017764-h1w9gbxk	312	24	to	to	TO
cord-017764-h1w9gbxk	312	25	cyclosporin	cyclosporin	VB
cord-017764-h1w9gbxk	312	26	A	a	DT
cord-017764-h1w9gbxk	312	27	Mechanisms	Mechanisms	NNPS
cord-017764-h1w9gbxk	312	28	of	of	IN
cord-017764-h1w9gbxk	312	29	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	312	30	C	c	NN
cord-017764-h1w9gbxk	312	31	viral	viral	JJ
cord-017764-h1w9gbxk	312	32	resistance	resistance	NN
cord-017764-h1w9gbxk	312	33	to	to	IN
cord-017764-h1w9gbxk	312	34	direct	direct	VB
cord-017764-h1w9gbxk	312	35	acting	act	VBG
cord-017764-h1w9gbxk	312	36	antivirals	antiviral	NNS
cord-017764-h1w9gbxk	312	37	From	from	IN
cord-017764-h1w9gbxk	312	38	structure	structure	NN
cord-017764-h1w9gbxk	312	39	to	to	TO
cord-017764-h1w9gbxk	312	40	function	function	VB
cord-017764-h1w9gbxk	312	41	:	:	:
cord-017764-h1w9gbxk	312	42	new	new	JJ
cord-017764-h1w9gbxk	312	43	insights	insight	NNS
cord-017764-h1w9gbxk	312	44	into	into	IN
cord-017764-h1w9gbxk	312	45	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	312	46	C	C	NNP
cord-017764-h1w9gbxk	312	47	virus	virus	NN
cord-017764-h1w9gbxk	312	48	RNA	RNA	NNP
cord-017764-h1w9gbxk	312	49	replication	replication	NN
cord-017764-h1w9gbxk	312	50	Inhibition	inhibition	NN
cord-017764-h1w9gbxk	312	51	and	and	CC
cord-017764-h1w9gbxk	312	52	avoidance	avoidance	NN
cord-017764-h1w9gbxk	312	53	of	of	IN
cord-017764-h1w9gbxk	312	54	mRNA	mRNA	NNP
cord-017764-h1w9gbxk	312	55	degradation	degradation	NN
cord-017764-h1w9gbxk	312	56	by	by	IN
cord-017764-h1w9gbxk	312	57	RNA	RNA	NNP
cord-017764-h1w9gbxk	312	58	viruses	virus	NNS
cord-017764-h1w9gbxk	312	59	Attacked	attack	VBN
cord-017764-h1w9gbxk	312	60	from	from	IN
cord-017764-h1w9gbxk	312	61	all	all	DT
cord-017764-h1w9gbxk	312	62	sides	side	NNS
cord-017764-h1w9gbxk	312	63	:	:	:
cord-017764-h1w9gbxk	312	64	RNA	RNA	NNP
cord-017764-h1w9gbxk	312	65	decay	decay	NN
cord-017764-h1w9gbxk	312	66	in	in	IN
cord-017764-h1w9gbxk	312	67	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	312	68	defense	defense	NN
cord-017764-h1w9gbxk	312	69	Small	small	JJ
cord-017764-h1w9gbxk	312	70	molecules	molecule	NNS
cord-017764-h1w9gbxk	312	71	targeting	target	VBG
cord-017764-h1w9gbxk	312	72	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	312	73	C	C	NNP
cord-017764-h1w9gbxk	312	74	virus	virus	NN
cord-017764-h1w9gbxk	312	75	-	-	HYPH
cord-017764-h1w9gbxk	312	76	encoded	encode	VBN
cord-017764-h1w9gbxk	312	77	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	312	78	cause	cause	VB
cord-017764-h1w9gbxk	312	79	subcellular	subcellular	JJ
cord-017764-h1w9gbxk	312	80	redistribution	redistribution	NN
cord-017764-h1w9gbxk	312	81	of	of	IN
cord-017764-h1w9gbxk	312	82	their	-PRON-	PRP$
cord-017764-h1w9gbxk	312	83	target	target	NN
cord-017764-h1w9gbxk	312	84	:	:	:
cord-017764-h1w9gbxk	312	85	insights	insight	NNS
cord-017764-h1w9gbxk	312	86	into	into	IN
cord-017764-h1w9gbxk	312	87	compound	compound	NN
cord-017764-h1w9gbxk	312	88	modes	mode	NNS
cord-017764-h1w9gbxk	312	89	of	of	IN
cord-017764-h1w9gbxk	312	90	action	action	NN
cord-017764-h1w9gbxk	313	1	The	the	DT
cord-017764-h1w9gbxk	313	2	effect	effect	NN
cord-017764-h1w9gbxk	313	3	of	of	IN
cord-017764-h1w9gbxk	313	4	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	313	5	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	313	6	on	on	IN
cord-017764-h1w9gbxk	313	7	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	313	8	phosphorylation	phosphorylation	NN
cord-017764-h1w9gbxk	313	9	,	,	,
cord-017764-h1w9gbxk	313	10	polyprotein	polyprotein	NN
cord-017764-h1w9gbxk	313	11	processing	processing	NN
cord-017764-h1w9gbxk	313	12	and	and	CC
cord-017764-h1w9gbxk	313	13	localization	localization	NN
cord-017764-h1w9gbxk	313	14	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	313	15	-	-	HYPH
cord-017764-h1w9gbxk	313	16	like	like	JJ
cord-017764-h1w9gbxk	313	17	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	313	18	of	of	IN
cord-017764-h1w9gbxk	313	19	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	313	20	block	block	VBP
cord-017764-h1w9gbxk	313	21	early	early	JJ
cord-017764-h1w9gbxk	313	22	biogenesis	biogenesis	NN
cord-017764-h1w9gbxk	313	23	of	of	IN
cord-017764-h1w9gbxk	313	24	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	313	25	C	C	NNP
cord-017764-h1w9gbxk	313	26	virus	virus	NN
cord-017764-h1w9gbxk	313	27	-	-	HYPH
cord-017764-h1w9gbxk	313	28	induced	induce	VBN
cord-017764-h1w9gbxk	313	29	membranous	membranous	JJ
cord-017764-h1w9gbxk	313	30	replication	replication	NN
cord-017764-h1w9gbxk	313	31	factories	factory	NNS
cord-017764-h1w9gbxk	313	32	,	,	,
cord-017764-h1w9gbxk	313	33	independent	independent	JJ
cord-017764-h1w9gbxk	313	34	of	of	IN
cord-017764-h1w9gbxk	313	35	RNA	RNA	NNP
cord-017764-h1w9gbxk	313	36	replication	replication	NN
cord-017764-h1w9gbxk	313	37	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	313	38	prevents	prevent	VBZ
cord-017764-h1w9gbxk	313	39	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	313	40	C	c	NN
cord-017764-h1w9gbxk	313	41	virus	virus	NN
cord-017764-h1w9gbxk	313	42	infectivity	infectivity	NN
cord-017764-h1w9gbxk	313	43	by	by	IN
cord-017764-h1w9gbxk	313	44	blocking	block	VBG
cord-017764-h1w9gbxk	313	45	transfer	transfer	NN
cord-017764-h1w9gbxk	313	46	of	of	IN
cord-017764-h1w9gbxk	313	47	the	the	DT
cord-017764-h1w9gbxk	313	48	viral	viral	JJ
cord-017764-h1w9gbxk	313	49	genome	genome	NN
cord-017764-h1w9gbxk	313	50	to	to	IN
cord-017764-h1w9gbxk	313	51	assembly	assembly	NN
cord-017764-h1w9gbxk	313	52	sites	site	NNS
cord-017764-h1w9gbxk	314	1	The	the	DT
cord-017764-h1w9gbxk	314	2	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	314	3	C	c	NN
cord-017764-h1w9gbxk	314	4	virus	virus	NN
cord-017764-h1w9gbxk	315	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	316	1	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	316	2	(	(	-LRB-
cord-017764-h1w9gbxk	316	3	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	316	4	)	)	-RRB-
cord-017764-h1w9gbxk	316	5	alters	alter	VBZ
cord-017764-h1w9gbxk	316	6	the	the	DT
cord-017764-h1w9gbxk	316	7	subcellular	subcellular	JJ
cord-017764-h1w9gbxk	316	8	localization	localization	NN
cord-017764-h1w9gbxk	316	9	of	of	IN
cord-017764-h1w9gbxk	316	10	the	the	DT
cord-017764-h1w9gbxk	316	11	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	316	12	non	non	JJ
cord-017764-h1w9gbxk	316	13	-	-	JJ
cord-017764-h1w9gbxk	316	14	structural	structural	JJ
cord-017764-h1w9gbxk	316	15	viral	viral	JJ
cord-017764-h1w9gbxk	316	16	protein	protein	NN
cord-017764-h1w9gbxk	316	17	Cyclophilin	Cyclophilin	NNP
cord-017764-h1w9gbxk	316	18	and	and	CC
cord-017764-h1w9gbxk	316	19	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	316	20	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	316	21	,	,	,
cord-017764-h1w9gbxk	316	22	but	but	CC
cord-017764-h1w9gbxk	316	23	not	not	RB
cord-017764-h1w9gbxk	316	24	other	other	JJ
cord-017764-h1w9gbxk	316	25	anti	anti	JJ
cord-017764-h1w9gbxk	316	26	-	-	JJ
cord-017764-h1w9gbxk	316	27	hepatitis	hepatitis	JJ
cord-017764-h1w9gbxk	316	28	C	c	NN
cord-017764-h1w9gbxk	316	29	virus	virus	NN
cord-017764-h1w9gbxk	316	30	(	(	-LRB-
cord-017764-h1w9gbxk	316	31	HCV	HCV	NNP
cord-017764-h1w9gbxk	316	32	)	)	-RRB-
cord-017764-h1w9gbxk	316	33	agents	agent	NNS
cord-017764-h1w9gbxk	316	34	,	,	,
cord-017764-h1w9gbxk	316	35	preclude	preclude	VB
cord-017764-h1w9gbxk	316	36	HCV	HCV	NNP
cord-017764-h1w9gbxk	316	37	-	-	HYPH
cord-017764-h1w9gbxk	316	38	mediated	mediate	VBN
cord-017764-h1w9gbxk	316	39	formation	formation	NN
cord-017764-h1w9gbxk	316	40	of	of	IN
cord-017764-h1w9gbxk	316	41	double	double	JJ
cord-017764-h1w9gbxk	316	42	-	-	HYPH
cord-017764-h1w9gbxk	316	43	membrane	membrane	NN
cord-017764-h1w9gbxk	316	44	-	-	HYPH
cord-017764-h1w9gbxk	316	45	vesicle	vesicle	NN
cord-017764-h1w9gbxk	316	46	viral	viral	JJ
cord-017764-h1w9gbxk	316	47	factories	factory	NNS
cord-017764-h1w9gbxk	316	48	Practical	practical	JJ
cord-017764-h1w9gbxk	316	49	and	and	CC
cord-017764-h1w9gbxk	316	50	efficient	efficient	JJ
cord-017764-h1w9gbxk	316	51	strategy	strategy	NN
cord-017764-h1w9gbxk	316	52	for	for	IN
cord-017764-h1w9gbxk	316	53	evaluating	evaluate	VBG
cord-017764-h1w9gbxk	316	54	oral	oral	JJ
cord-017764-h1w9gbxk	316	55	absolute	absolute	JJ
cord-017764-h1w9gbxk	316	56	bioavailability	bioavailability	NN
cord-017764-h1w9gbxk	316	57	with	with	IN
cord-017764-h1w9gbxk	316	58	an	an	DT
cord-017764-h1w9gbxk	316	59	intravenous	intravenous	JJ
cord-017764-h1w9gbxk	316	60	microdose	microdose	NN
cord-017764-h1w9gbxk	316	61	of	of	IN
cord-017764-h1w9gbxk	316	62	a	a	DT
cord-017764-h1w9gbxk	316	63	stable	stable	JJ
cord-017764-h1w9gbxk	316	64	isotopically	isotopically	RB
cord-017764-h1w9gbxk	316	65	-	-	HYPH
cord-017764-h1w9gbxk	316	66	labeled	label	VBN
cord-017764-h1w9gbxk	316	67	drug	drug	NN
cord-017764-h1w9gbxk	316	68	using	use	VBG
cord-017764-h1w9gbxk	316	69	a	a	DT
cord-017764-h1w9gbxk	316	70	selected	select	VBN
cord-017764-h1w9gbxk	316	71	reaction	reaction	NN
cord-017764-h1w9gbxk	316	72	monitoring	monitor	VBG
cord-017764-h1w9gbxk	316	73	mass	mass	NN
cord-017764-h1w9gbxk	316	74	spectrometry	spectrometry	NN
cord-017764-h1w9gbxk	316	75	assay	assay	NN
cord-017764-h1w9gbxk	316	76	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	316	77	:	:	:
cord-017764-h1w9gbxk	316	78	a	a	DT
cord-017764-h1w9gbxk	316	79	review	review	NN
cord-017764-h1w9gbxk	316	80	of	of	IN
cord-017764-h1w9gbxk	316	81	its	-PRON-	PRP$
cord-017764-h1w9gbxk	316	82	use	use	NN
cord-017764-h1w9gbxk	316	83	in	in	IN
cord-017764-h1w9gbxk	316	84	adult	adult	NN
cord-017764-h1w9gbxk	316	85	patients	patient	NNS
cord-017764-h1w9gbxk	316	86	with	with	IN
cord-017764-h1w9gbxk	316	87	chronic	chronic	JJ
cord-017764-h1w9gbxk	316	88	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	89	C	c	NN
cord-017764-h1w9gbxk	316	90	virus	virus	NN
cord-017764-h1w9gbxk	316	91	infection	infection	NN
cord-017764-h1w9gbxk	316	92	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	316	93	:	:	:
cord-017764-h1w9gbxk	316	94	a	a	DT
cord-017764-h1w9gbxk	316	95	review	review	NN
cord-017764-h1w9gbxk	316	96	of	of	IN
cord-017764-h1w9gbxk	316	97	preclinical	preclinical	JJ
cord-017764-h1w9gbxk	316	98	and	and	CC
cord-017764-h1w9gbxk	316	99	clinical	clinical	JJ
cord-017764-h1w9gbxk	316	100	pharmacokinetics	pharmacokinetic	NNS
cord-017764-h1w9gbxk	316	101	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	316	102	:	:	:
cord-017764-h1w9gbxk	316	103	a	a	DT
cord-017764-h1w9gbxk	316	104	review	review	NN
cord-017764-h1w9gbxk	316	105	in	in	IN
cord-017764-h1w9gbxk	316	106	chronic	chronic	JJ
cord-017764-h1w9gbxk	316	107	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	108	C	C	NNP
cord-017764-h1w9gbxk	316	109	Contribution	Contribution	NNP
cord-017764-h1w9gbxk	316	110	of	of	IN
cord-017764-h1w9gbxk	316	111	a	a	DT
cord-017764-h1w9gbxk	316	112	mutational	mutational	JJ
cord-017764-h1w9gbxk	316	113	bias	bias	NN
cord-017764-h1w9gbxk	316	114	in	in	IN
cord-017764-h1w9gbxk	316	115	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	116	C	C	NNP
cord-017764-h1w9gbxk	316	117	virus	virus	NN
cord-017764-h1w9gbxk	316	118	replication	replication	NN
cord-017764-h1w9gbxk	316	119	to	to	IN
cord-017764-h1w9gbxk	316	120	the	the	DT
cord-017764-h1w9gbxk	316	121	genetic	genetic	JJ
cord-017764-h1w9gbxk	316	122	barrier	barrier	NN
cord-017764-h1w9gbxk	316	123	in	in	IN
cord-017764-h1w9gbxk	316	124	the	the	DT
cord-017764-h1w9gbxk	316	125	development	development	NN
cord-017764-h1w9gbxk	316	126	of	of	IN
cord-017764-h1w9gbxk	316	127	drug	drug	NN
cord-017764-h1w9gbxk	316	128	resistance	resistance	NN
cord-017764-h1w9gbxk	316	129	Antiviral	antiviral	JJ
cord-017764-h1w9gbxk	316	130	resistance	resistance	NN
cord-017764-h1w9gbxk	316	131	and	and	CC
cord-017764-h1w9gbxk	316	132	the	the	DT
cord-017764-h1w9gbxk	316	133	future	future	JJ
cord-017764-h1w9gbxk	316	134	landscape	landscape	NN
cord-017764-h1w9gbxk	316	135	of	of	IN
cord-017764-h1w9gbxk	316	136	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	137	C	C	NNP
cord-017764-h1w9gbxk	316	138	virus	virus	NN
cord-017764-h1w9gbxk	316	139	infection	infection	NN
cord-017764-h1w9gbxk	316	140	therapy	therapy	NN
cord-017764-h1w9gbxk	316	141	Importance	importance	NN
cord-017764-h1w9gbxk	316	142	of	of	IN
cord-017764-h1w9gbxk	316	143	HCV	HCV	NNP
cord-017764-h1w9gbxk	316	144	genotype	genotype	NN
cord-017764-h1w9gbxk	316	145	1	1	CD
cord-017764-h1w9gbxk	316	146	subtypes	subtype	NNS
cord-017764-h1w9gbxk	316	147	for	for	IN
cord-017764-h1w9gbxk	316	148	drug	drug	NN
cord-017764-h1w9gbxk	316	149	resistance	resistance	NN
cord-017764-h1w9gbxk	316	150	and	and	CC
cord-017764-h1w9gbxk	316	151	response	response	NN
cord-017764-h1w9gbxk	316	152	to	to	IN
cord-017764-h1w9gbxk	316	153	therapy	therapy	NN
cord-017764-h1w9gbxk	316	154	Genotypic	Genotypic	NNP
cord-017764-h1w9gbxk	316	155	and	and	CC
cord-017764-h1w9gbxk	316	156	phenotypic	phenotypic	JJ
cord-017764-h1w9gbxk	316	157	analysis	analysis	NN
cord-017764-h1w9gbxk	316	158	of	of	IN
cord-017764-h1w9gbxk	316	159	variants	variant	NNS
cord-017764-h1w9gbxk	316	160	resistant	resistant	JJ
cord-017764-h1w9gbxk	316	161	to	to	IN
cord-017764-h1w9gbxk	316	162	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	163	C	C	NNP
cord-017764-h1w9gbxk	316	164	virus	virus	NN
cord-017764-h1w9gbxk	316	165	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	316	166	protein	protein	NN
cord-017764-h1w9gbxk	316	167	5A	5a	CD
cord-017764-h1w9gbxk	316	168	replication	replication	NN
cord-017764-h1w9gbxk	316	169	complex	complex	JJ
cord-017764-h1w9gbxk	316	170	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	316	171	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	316	172	in	in	IN
cord-017764-h1w9gbxk	316	173	humans	human	NNS
cord-017764-h1w9gbxk	316	174	:	:	:
cord-017764-h1w9gbxk	316	175	in	in	IN
cord-017764-h1w9gbxk	316	176	vitro	vitro	FW
cord-017764-h1w9gbxk	316	177	and	and	CC
cord-017764-h1w9gbxk	316	178	in	in	IN
cord-017764-h1w9gbxk	316	179	vivo	vivo	NNP
cord-017764-h1w9gbxk	316	180	correlations	correlation	NNS
cord-017764-h1w9gbxk	316	181	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	316	182	C	C	NNP
cord-017764-h1w9gbxk	316	183	virus	virus	NN
cord-017764-h1w9gbxk	316	184	RNA	rna	NN
cord-017764-h1w9gbxk	316	185	elimination	elimination	NN
cord-017764-h1w9gbxk	316	186	and	and	CC
cord-017764-h1w9gbxk	316	187	development	development	NN
cord-017764-h1w9gbxk	316	188	of	of	IN
cord-017764-h1w9gbxk	316	189	resistance	resistance	NN
cord-017764-h1w9gbxk	316	190	in	in	IN
cord-017764-h1w9gbxk	316	191	replicon	replicon	NN
cord-017764-h1w9gbxk	316	192	cells	cell	NNS
cord-017764-h1w9gbxk	316	193	treated	treat	VBN
cord-017764-h1w9gbxk	316	194	with	with	IN
cord-017764-h1w9gbxk	316	195	BMS-790052	BMS-790052	NNP
cord-017764-h1w9gbxk	316	196	Hepatitis	Hepatitis	NNP
cord-017764-h1w9gbxk	316	197	C	C	NNP
cord-017764-h1w9gbxk	316	198	viral	viral	JJ
cord-017764-h1w9gbxk	316	199	dynamics	dynamic	NNS
cord-017764-h1w9gbxk	316	200	in	in	IN
cord-017764-h1w9gbxk	316	201	vivo	vivo	NN
cord-017764-h1w9gbxk	316	202	and	and	CC
cord-017764-h1w9gbxk	316	203	the	the	DT
cord-017764-h1w9gbxk	316	204	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	316	205	efficacy	efficacy	NN
cord-017764-h1w9gbxk	316	206	of	of	IN
cord-017764-h1w9gbxk	316	207	interferon	interferon	NN
cord-017764-h1w9gbxk	316	208	-	-	HYPH
cord-017764-h1w9gbxk	316	209	α	α	NN
cord-017764-h1w9gbxk	316	210	therapy	therapy	NN
cord-017764-h1w9gbxk	316	211	New	new	JJ
cord-017764-h1w9gbxk	316	212	kinetic	kinetic	JJ
cord-017764-h1w9gbxk	316	213	models	model	NNS
cord-017764-h1w9gbxk	316	214	for	for	IN
cord-017764-h1w9gbxk	316	215	the	the	DT
cord-017764-h1w9gbxk	316	216	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	217	C	C	NNP
cord-017764-h1w9gbxk	316	218	virus	virus	NN
cord-017764-h1w9gbxk	316	219	Modeling	model	VBG
cord-017764-h1w9gbxk	316	220	HCV	HCV	NNP
cord-017764-h1w9gbxk	316	221	kinetics	kinetic	NNS
cord-017764-h1w9gbxk	316	222	under	under	IN
cord-017764-h1w9gbxk	316	223	therapy	therapy	NN
cord-017764-h1w9gbxk	316	224	using	use	VBG
cord-017764-h1w9gbxk	316	225	PK	PK	NNP
cord-017764-h1w9gbxk	316	226	and	and	CC
cord-017764-h1w9gbxk	316	227	PD	PD	NNP
cord-017764-h1w9gbxk	316	228	information	information	NN
cord-017764-h1w9gbxk	316	229	Treatment	treatment	NN
cord-017764-h1w9gbxk	316	230	of	of	IN
cord-017764-h1w9gbxk	316	231	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	232	C	C	NNP
cord-017764-h1w9gbxk	316	233	virus	virus	NN
cord-017764-h1w9gbxk	316	234	infection	infection	NN
cord-017764-h1w9gbxk	316	235	with	with	IN
cord-017764-h1w9gbxk	316	236	interferon	interferon	NN
cord-017764-h1w9gbxk	316	237	and	and	CC
cord-017764-h1w9gbxk	316	238	small	small	JJ
cord-017764-h1w9gbxk	316	239	molecule	molecule	NN
cord-017764-h1w9gbxk	316	240	direct	direct	JJ
cord-017764-h1w9gbxk	316	241	antivirals	antiviral	NNS
cord-017764-h1w9gbxk	316	242	:	:	:
cord-017764-h1w9gbxk	316	243	viral	viral	JJ
cord-017764-h1w9gbxk	316	244	kinetics	kinetic	NNS
cord-017764-h1w9gbxk	316	245	and	and	CC
cord-017764-h1w9gbxk	316	246	modeling	model	VBG
cord-017764-h1w9gbxk	316	247	Quantifying	quantify	VBG
cord-017764-h1w9gbxk	316	248	the	the	DT
cord-017764-h1w9gbxk	316	249	diversification	diversification	NN
cord-017764-h1w9gbxk	316	250	of	of	IN
cord-017764-h1w9gbxk	316	251	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	316	252	C	C	NNP
cord-017764-h1w9gbxk	316	253	virus	virus	NN
cord-017764-h1w9gbxk	316	254	(	(	-LRB-
cord-017764-h1w9gbxk	316	255	HCV	HCV	NNP
cord-017764-h1w9gbxk	316	256	)	)	-RRB-
cord-017764-h1w9gbxk	316	257	during	during	IN
cord-017764-h1w9gbxk	316	258	primary	primary	JJ
cord-017764-h1w9gbxk	316	259	infection	infection	NN
cord-017764-h1w9gbxk	316	260	:	:	:
cord-017764-h1w9gbxk	316	261	estimates	estimate	NNS
cord-017764-h1w9gbxk	316	262	of	of	IN
cord-017764-h1w9gbxk	316	263	the	the	DT
cord-017764-h1w9gbxk	316	264	in	in	IN
cord-017764-h1w9gbxk	316	265	vivo	vivo	NN
cord-017764-h1w9gbxk	316	266	mutation	mutation	NN
cord-017764-h1w9gbxk	316	267	rate	rate	NN
cord-017764-h1w9gbxk	317	1	The	the	DT
cord-017764-h1w9gbxk	317	2	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	317	3	and	and	CC
cord-017764-h1w9gbxk	317	4	Development	Development	NNP
cord-017764-h1w9gbxk	317	5	of	of	IN
cord-017764-h1w9gbxk	317	6	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	317	7	:	:	:
cord-017764-h1w9gbxk	318	1	An	an	DT
cord-017764-h1w9gbxk	318	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	318	3	of	of	IN
cord-017764-h1w9gbxk	318	4	the	the	DT
cord-017764-h1w9gbxk	318	5	Mathematical	mathematical	JJ
cord-017764-h1w9gbxk	318	6	modeling	modeling	NN
cord-017764-h1w9gbxk	318	7	of	of	IN
cord-017764-h1w9gbxk	318	8	HCV	HCV	NNP
cord-017764-h1w9gbxk	318	9	infection	infection	NN
cord-017764-h1w9gbxk	318	10	:	:	:
cord-017764-h1w9gbxk	318	11	what	what	WP
cord-017764-h1w9gbxk	318	12	can	can	MD
cord-017764-h1w9gbxk	318	13	it	-PRON-	PRP
cord-017764-h1w9gbxk	318	14	teach	teach	VB
cord-017764-h1w9gbxk	318	15	us	-PRON-	PRP
cord-017764-h1w9gbxk	318	16	in	in	IN
cord-017764-h1w9gbxk	318	17	the	the	DT
cord-017764-h1w9gbxk	318	18	era	era	NN
cord-017764-h1w9gbxk	318	19	of	of	IN
cord-017764-h1w9gbxk	318	20	direct	direct	JJ
cord-017764-h1w9gbxk	318	21	-	-	HYPH
cord-017764-h1w9gbxk	318	22	acting	act	VBG
cord-017764-h1w9gbxk	318	23	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	318	24	agents	agent	NNS
cord-017764-h1w9gbxk	318	25	?	?	.
cord-017764-h1w9gbxk	319	1	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	319	2	plus	plus	CC
cord-017764-h1w9gbxk	319	3	peginterferon	peginterferon	NNP
cord-017764-h1w9gbxk	319	4	alfa	alfa	NNP
cord-017764-h1w9gbxk	319	5	and	and	CC
cord-017764-h1w9gbxk	319	6	ribavirin	ribavirin	NNP
cord-017764-h1w9gbxk	319	7	for	for	IN
cord-017764-h1w9gbxk	319	8	treatment	treatment	NN
cord-017764-h1w9gbxk	319	9	-	-	HYPH
cord-017764-h1w9gbxk	319	10	naive	naive	JJ
cord-017764-h1w9gbxk	319	11	chronic	chronic	JJ
cord-017764-h1w9gbxk	319	12	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	319	13	C	c	NN
cord-017764-h1w9gbxk	319	14	genotype	genotype	NN
cord-017764-h1w9gbxk	319	15	1	1	CD
cord-017764-h1w9gbxk	319	16	or	or	CC
cord-017764-h1w9gbxk	319	17	4	4	CD
cord-017764-h1w9gbxk	319	18	infection	infection	NN
cord-017764-h1w9gbxk	319	19	:	:	:
cord-017764-h1w9gbxk	319	20	a	a	DT
cord-017764-h1w9gbxk	319	21	randomised	randomised	JJ
cord-017764-h1w9gbxk	319	22	study	study	NN
cord-017764-h1w9gbxk	319	23	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	319	24	plus	plus	CC
cord-017764-h1w9gbxk	319	25	peginterferon	peginterferon	NNP
cord-017764-h1w9gbxk	319	26	and	and	CC
cord-017764-h1w9gbxk	319	27	ribavirin	ribavirin	NN
cord-017764-h1w9gbxk	319	28	is	be	VBZ
cord-017764-h1w9gbxk	319	29	noninferior	noninferior	JJ
cord-017764-h1w9gbxk	319	30	to	to	TO
cord-017764-h1w9gbxk	319	31	peginterferon	peginterferon	JJ
cord-017764-h1w9gbxk	319	32	and	and	CC
cord-017764-h1w9gbxk	319	33	ribavirin	ribavirin	RB
cord-017764-h1w9gbxk	319	34	alone	alone	RB
cord-017764-h1w9gbxk	319	35	,	,	,
cord-017764-h1w9gbxk	319	36	and	and	CC
cord-017764-h1w9gbxk	319	37	reduces	reduce	VBZ
cord-017764-h1w9gbxk	319	38	the	the	DT
cord-017764-h1w9gbxk	319	39	duration	duration	NN
cord-017764-h1w9gbxk	319	40	of	of	IN
cord-017764-h1w9gbxk	319	41	treatment	treatment	NN
cord-017764-h1w9gbxk	319	42	for	for	IN
cord-017764-h1w9gbxk	319	43	HCV	HCV	NNP
cord-017764-h1w9gbxk	319	44	genotype	genotype	NNP
cord-017764-h1w9gbxk	319	45	2	2	CD
cord-017764-h1w9gbxk	319	46	or	or	CC
cord-017764-h1w9gbxk	319	47	3	3	CD
cord-017764-h1w9gbxk	319	48	infection	infection	NN
cord-017764-h1w9gbxk	319	49	Efficacy	efficacy	NN
cord-017764-h1w9gbxk	319	50	and	and	CC
cord-017764-h1w9gbxk	319	51	safety	safety	NN
cord-017764-h1w9gbxk	319	52	of	of	IN
cord-017764-h1w9gbxk	319	53	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	319	54	plus	plus	CC
cord-017764-h1w9gbxk	319	55	pegylated	pegylate	VBN
cord-017764-h1w9gbxk	319	56	-	-	HYPH
cord-017764-h1w9gbxk	319	57	interferon	interferon	JJ
cord-017764-h1w9gbxk	319	58	alfa	alfa	NNP
cord-017764-h1w9gbxk	319	59	2a	2a	CD
cord-017764-h1w9gbxk	319	60	and	and	CC
cord-017764-h1w9gbxk	319	61	ribavirin	ribavirin	RB
cord-017764-h1w9gbxk	319	62	in	in	IN
cord-017764-h1w9gbxk	319	63	previously	previously	RB
cord-017764-h1w9gbxk	319	64	untreated	untreated	JJ
cord-017764-h1w9gbxk	319	65	HCV	HCV	NNP
cord-017764-h1w9gbxk	319	66	subjects	subject	NNS
cord-017764-h1w9gbxk	319	67	coinfected	coinfecte	VBD
cord-017764-h1w9gbxk	319	68	with	with	IN
cord-017764-h1w9gbxk	319	69	HIV	HIV	NNP
cord-017764-h1w9gbxk	319	70	and	and	CC
cord-017764-h1w9gbxk	319	71	HCV	HCV	NNP
cord-017764-h1w9gbxk	319	72	genotype-1	genotype-1	NNP
cord-017764-h1w9gbxk	319	73	:	:	:
cord-017764-h1w9gbxk	319	74	a	a	DT
cord-017764-h1w9gbxk	319	75	phase	phase	NN
cord-017764-h1w9gbxk	319	76	III	iii	CD
cord-017764-h1w9gbxk	319	77	,	,	,
cord-017764-h1w9gbxk	319	78	open	open	JJ
cord-017764-h1w9gbxk	319	79	-	-	HYPH
cord-017764-h1w9gbxk	319	80	label	label	NN
cord-017764-h1w9gbxk	319	81	study	study	NN
cord-017764-h1w9gbxk	319	82	A	a	DT
cord-017764-h1w9gbxk	319	83	randomized	randomized	JJ
cord-017764-h1w9gbxk	319	84	trial	trial	NN
cord-017764-h1w9gbxk	319	85	of	of	IN
cord-017764-h1w9gbxk	319	86	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	319	87	with	with	IN
cord-017764-h1w9gbxk	319	88	peginterferon	peginterferon	NNP
cord-017764-h1w9gbxk	319	89	alfa-2b	alfa-2b	NNP
cord-017764-h1w9gbxk	319	90	and	and	CC
cord-017764-h1w9gbxk	319	91	ribavirin	ribavirin	RB
cord-017764-h1w9gbxk	319	92	for	for	IN
cord-017764-h1w9gbxk	319	93	HCV	HCV	NNP
cord-017764-h1w9gbxk	319	94	genotype	genotype	NN
cord-017764-h1w9gbxk	319	95	1	1	CD
cord-017764-h1w9gbxk	319	96	infection	infection	NN
cord-017764-h1w9gbxk	320	1	Daclatasvir	Daclatasvir	NNS
cord-017764-h1w9gbxk	320	2	combined	combine	VBN
cord-017764-h1w9gbxk	320	3	with	with	IN
cord-017764-h1w9gbxk	320	4	peginterferon	peginterferon	NNP
cord-017764-h1w9gbxk	321	1	alfa-2a	alfa-2a	JJ
cord-017764-h1w9gbxk	321	2	and	and	CC
cord-017764-h1w9gbxk	321	3	ribavirin	ribavirin	RB
cord-017764-h1w9gbxk	321	4	in	in	IN
cord-017764-h1w9gbxk	321	5	Japanese	japanese	JJ
cord-017764-h1w9gbxk	321	6	patients	patient	NNS
cord-017764-h1w9gbxk	321	7	infected	infect	VBN
cord-017764-h1w9gbxk	321	8	with	with	IN
cord-017764-h1w9gbxk	321	9	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	321	10	C	C	NNP
cord-017764-h1w9gbxk	321	11	genotype	genotype	NN
cord-017764-h1w9gbxk	321	12	1	1	CD
cord-017764-h1w9gbxk	322	1	The	the	DT
cord-017764-h1w9gbxk	322	2	discovery	discovery	NN
cord-017764-h1w9gbxk	322	3	of	of	IN
cord-017764-h1w9gbxk	322	4	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	322	5	(	(	-LRB-
cord-017764-h1w9gbxk	322	6	BMS-650032	BMS-650032	NNP
cord-017764-h1w9gbxk	322	7	)	)	-RRB-
cord-017764-h1w9gbxk	322	8	,	,	,
cord-017764-h1w9gbxk	322	9	an	an	DT
cord-017764-h1w9gbxk	322	10	orally	orally	RB
cord-017764-h1w9gbxk	322	11	efficacious	efficacious	JJ
cord-017764-h1w9gbxk	322	12	NS3	ns3	JJ
cord-017764-h1w9gbxk	322	13	protease	protease	NN
cord-017764-h1w9gbxk	322	14	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	322	15	for	for	IN
cord-017764-h1w9gbxk	322	16	the	the	DT
cord-017764-h1w9gbxk	322	17	treatment	treatment	NN
cord-017764-h1w9gbxk	322	18	of	of	IN
cord-017764-h1w9gbxk	322	19	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	322	20	C	C	NNP
cord-017764-h1w9gbxk	322	21	virus	virus	NN
cord-017764-h1w9gbxk	322	22	infection	infection	NN
cord-017764-h1w9gbxk	322	23	Preclinical	preclinical	JJ
cord-017764-h1w9gbxk	322	24	profile	profile	NN
cord-017764-h1w9gbxk	322	25	and	and	CC
cord-017764-h1w9gbxk	322	26	characterization	characterization	NN
cord-017764-h1w9gbxk	322	27	of	of	IN
cord-017764-h1w9gbxk	322	28	the	the	DT
cord-017764-h1w9gbxk	322	29	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	322	30	C	C	NNP
cord-017764-h1w9gbxk	322	31	virus	virus	NN
cord-017764-h1w9gbxk	322	32	NS3	ns3	RB
cord-017764-h1w9gbxk	322	33	protease	protease	NN
cord-017764-h1w9gbxk	322	34	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	322	35	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	322	36	(	(	-LRB-
cord-017764-h1w9gbxk	322	37	BMS-650032	BMS-650032	NNP
cord-017764-h1w9gbxk	322	38	)	)	-RRB-
cord-017764-h1w9gbxk	323	1	Preliminary	preliminary	JJ
cord-017764-h1w9gbxk	323	2	study	study	NN
cord-017764-h1w9gbxk	323	3	of	of	IN
cord-017764-h1w9gbxk	323	4	two	two	CD
cord-017764-h1w9gbxk	323	5	antiviral	antiviral	JJ
cord-017764-h1w9gbxk	323	6	agents	agent	NNS
cord-017764-h1w9gbxk	323	7	for	for	IN
cord-017764-h1w9gbxk	323	8	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	323	9	C	C	NNP
cord-017764-h1w9gbxk	323	10	genotype	genotype	NN
cord-017764-h1w9gbxk	324	1	1	1	LS
cord-017764-h1w9gbxk	324	2	A	a	DT
cord-017764-h1w9gbxk	324	3	watershed	watershed	JJ
cord-017764-h1w9gbxk	324	4	moment	moment	NN
cord-017764-h1w9gbxk	324	5	in	in	IN
cord-017764-h1w9gbxk	324	6	the	the	DT
cord-017764-h1w9gbxk	324	7	treatment	treatment	NN
cord-017764-h1w9gbxk	324	8	of	of	IN
cord-017764-h1w9gbxk	324	9	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	324	10	C	C	NNP
cord-017764-h1w9gbxk	324	11	Resistance	Resistance	NNP
cord-017764-h1w9gbxk	324	12	analysis	analysis	NN
cord-017764-h1w9gbxk	324	13	of	of	IN
cord-017764-h1w9gbxk	324	14	the	the	DT
cord-017764-h1w9gbxk	324	15	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	324	16	C	C	NNP
cord-017764-h1w9gbxk	324	17	virus	virus	NN
cord-017764-h1w9gbxk	324	18	NS3	ns3	RB
cord-017764-h1w9gbxk	324	19	protease	protease	NN
cord-017764-h1w9gbxk	324	20	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	325	1	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	326	1	Randomized	randomized	JJ
cord-017764-h1w9gbxk	326	2	trial	trial	NN
cord-017764-h1w9gbxk	326	3	of	of	IN
cord-017764-h1w9gbxk	326	4	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	326	5	and	and	CC
cord-017764-h1w9gbxk	326	6	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	326	7	52	52	CD
cord-017764-h1w9gbxk	326	8	N.	n.	NN
cord-017764-h1w9gbxk	326	9	A.	a.	NN
cord-017764-h1w9gbxk	326	10	Meanwell	Meanwell	NNP
cord-017764-h1w9gbxk	326	11	and	and	CC
cord-017764-h1w9gbxk	326	12	M.	M.	NNP
cord-017764-h1w9gbxk	326	13	Belema	Belema	NNP
cord-017764-h1w9gbxk	326	14	with	with	IN
cord-017764-h1w9gbxk	326	15	or	or	CC
cord-017764-h1w9gbxk	326	16	without	without	IN
cord-017764-h1w9gbxk	326	17	PegIFN	PegIFN	NNP
cord-017764-h1w9gbxk	326	18	/	/	SYM
cord-017764-h1w9gbxk	326	19	RBV	RBV	NNP
cord-017764-h1w9gbxk	326	20	for	for	IN
cord-017764-h1w9gbxk	326	21	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	326	22	C	C	NNP
cord-017764-h1w9gbxk	326	23	virus	virus	NN
cord-017764-h1w9gbxk	326	24	genotype	genotype	NN
cord-017764-h1w9gbxk	327	1	1	1	CD
cord-017764-h1w9gbxk	327	2	null	null	JJ
cord-017764-h1w9gbxk	327	3	responders	responder	NNS
cord-017764-h1w9gbxk	327	4	Changes	change	NNS
cord-017764-h1w9gbxk	327	5	in	in	IN
cord-017764-h1w9gbxk	327	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	327	7	C	C	NNP
cord-017764-h1w9gbxk	327	8	virus	virus	NN
cord-017764-h1w9gbxk	327	9	genotype	genotype	NN
cord-017764-h1w9gbxk	327	10	distribution	distribution	NN
cord-017764-h1w9gbxk	327	11	in	in	IN
cord-017764-h1w9gbxk	327	12	Japan	Japan	NNP
cord-017764-h1w9gbxk	327	13	Changing	change	VBG
cord-017764-h1w9gbxk	327	14	trends	trend	NNS
cord-017764-h1w9gbxk	327	15	in	in	IN
cord-017764-h1w9gbxk	327	16	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	327	17	C	C	NNP
cord-017764-h1w9gbxk	327	18	infection	infection	NN
cord-017764-h1w9gbxk	327	19	over	over	IN
cord-017764-h1w9gbxk	327	20	the	the	DT
cord-017764-h1w9gbxk	327	21	past	past	JJ
cord-017764-h1w9gbxk	327	22	50	50	CD
cord-017764-h1w9gbxk	327	23	years	year	NNS
cord-017764-h1w9gbxk	327	24	in	in	IN
cord-017764-h1w9gbxk	327	25	Japan	Japan	NNP
cord-017764-h1w9gbxk	327	26	Dual	dual	JJ
cord-017764-h1w9gbxk	327	27	therapy	therapy	NN
cord-017764-h1w9gbxk	327	28	with	with	IN
cord-017764-h1w9gbxk	327	29	the	the	DT
cord-017764-h1w9gbxk	327	30	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	327	31	protein	protein	NN
cord-017764-h1w9gbxk	327	32	5A	5a	CD
cord-017764-h1w9gbxk	327	33	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	327	34	,	,	,
cord-017764-h1w9gbxk	327	35	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	327	36	,	,	,
cord-017764-h1w9gbxk	327	37	and	and	CC
cord-017764-h1w9gbxk	327	38	the	the	DT
cord-017764-h1w9gbxk	327	39	nonstructural	nonstructural	JJ
cord-017764-h1w9gbxk	327	40	protein	protein	NN
cord-017764-h1w9gbxk	327	41	3	3	CD
cord-017764-h1w9gbxk	327	42	protease	protease	NN
cord-017764-h1w9gbxk	327	43	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	327	44	,	,	,
cord-017764-h1w9gbxk	327	45	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	327	46	,	,	,
cord-017764-h1w9gbxk	327	47	in	in	IN
cord-017764-h1w9gbxk	327	48	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	327	49	C	C	NNP
cord-017764-h1w9gbxk	327	50	virus	virus	NN
cord-017764-h1w9gbxk	327	51	genotype	genotype	NN
cord-017764-h1w9gbxk	327	52	1b	1b	CD
cord-017764-h1w9gbxk	327	53	-	-	HYPH
cord-017764-h1w9gbxk	327	54	infected	infect	VBN
cord-017764-h1w9gbxk	327	55	null	null	JJ
cord-017764-h1w9gbxk	327	56	responders	responder	NNS
cord-017764-h1w9gbxk	327	57	Effectiveness	Effectiveness	NNP
cord-017764-h1w9gbxk	327	58	and	and	CC
cord-017764-h1w9gbxk	327	59	safety	safety	NN
cord-017764-h1w9gbxk	327	60	of	of	IN
cord-017764-h1w9gbxk	327	61	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	327	62	plus	plus	CC
cord-017764-h1w9gbxk	327	63	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	327	64	for	for	IN
cord-017764-h1w9gbxk	327	65	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	327	66	C	C	NNP
cord-017764-h1w9gbxk	327	67	virus	virus	NN
cord-017764-h1w9gbxk	327	68	genotype	genotype	NN
cord-017764-h1w9gbxk	327	69	1b	1b	CD
cord-017764-h1w9gbxk	327	70	:	:	:
cord-017764-h1w9gbxk	327	71	systematic	systematic	JJ
cord-017764-h1w9gbxk	327	72	review	review	NN
cord-017764-h1w9gbxk	327	73	and	and	CC
cord-017764-h1w9gbxk	327	74	meta	meta	NNP
cord-017764-h1w9gbxk	327	75	-	-	HYPH
cord-017764-h1w9gbxk	327	76	analysis	analysis	NN
cord-017764-h1w9gbxk	328	1	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	328	2	+	+	CC
cord-017764-h1w9gbxk	328	3	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	328	4	:	:	:
cord-017764-h1w9gbxk	329	1	first	first	JJ
cord-017764-h1w9gbxk	329	2	global	global	JJ
cord-017764-h1w9gbxk	329	3	approval	approval	NN
cord-017764-h1w9gbxk	329	4	Characterization	characterization	NN
cord-017764-h1w9gbxk	329	5	of	of	IN
cord-017764-h1w9gbxk	329	6	virologic	virologic	JJ
cord-017764-h1w9gbxk	329	7	escape	escape	NN
cord-017764-h1w9gbxk	329	8	in	in	IN
cord-017764-h1w9gbxk	329	9	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	329	10	C	C	NNP
cord-017764-h1w9gbxk	329	11	virus	virus	NN
cord-017764-h1w9gbxk	329	12	genotype	genotype	NN
cord-017764-h1w9gbxk	329	13	1b	1b	CD
cord-017764-h1w9gbxk	329	14	patients	patient	NNS
cord-017764-h1w9gbxk	329	15	treated	treat	VBN
cord-017764-h1w9gbxk	329	16	with	with	IN
cord-017764-h1w9gbxk	329	17	the	the	DT
cord-017764-h1w9gbxk	329	18	direct	direct	JJ
cord-017764-h1w9gbxk	329	19	acting	act	VBG
cord-017764-h1w9gbxk	329	20	antivirals	antiviral	NNS
cord-017764-h1w9gbxk	329	21	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	329	22	and	and	CC
cord-017764-h1w9gbxk	329	23	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	329	24	Dual	dual	JJ
cord-017764-h1w9gbxk	329	25	oral	oral	JJ
cord-017764-h1w9gbxk	329	26	therapy	therapy	NN
cord-017764-h1w9gbxk	329	27	with	with	IN
cord-017764-h1w9gbxk	329	28	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	329	29	and	and	CC
cord-017764-h1w9gbxk	329	30	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	329	31	for	for	IN
cord-017764-h1w9gbxk	329	32	patients	patient	NNS
cord-017764-h1w9gbxk	329	33	with	with	IN
cord-017764-h1w9gbxk	329	34	HCV	HCV	NNP
cord-017764-h1w9gbxk	329	35	genotype	genotype	NN
cord-017764-h1w9gbxk	329	36	1b	1b	CD
cord-017764-h1w9gbxk	329	37	infection	infection	NN
cord-017764-h1w9gbxk	329	38	and	and	CC
cord-017764-h1w9gbxk	329	39	limited	limited	JJ
cord-017764-h1w9gbxk	329	40	treatment	treatment	NN
cord-017764-h1w9gbxk	329	41	options	option	NNS
cord-017764-h1w9gbxk	329	42	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	329	43	plus	plus	CC
cord-017764-h1w9gbxk	329	44	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	329	45	for	for	IN
cord-017764-h1w9gbxk	329	46	chronic	chronic	JJ
cord-017764-h1w9gbxk	329	47	HCV	HCV	NNP
cord-017764-h1w9gbxk	329	48	genotype	genotype	NN
cord-017764-h1w9gbxk	329	49	1b	1b	CD
cord-017764-h1w9gbxk	329	50	infection	infection	NN
cord-017764-h1w9gbxk	329	51	High	High	NNP
cord-017764-h1w9gbxk	329	52	sustained	sustain	VBD
cord-017764-h1w9gbxk	329	53	virologic	virologic	JJ
cord-017764-h1w9gbxk	329	54	response	response	NN
cord-017764-h1w9gbxk	329	55	to	to	IN
cord-017764-h1w9gbxk	329	56	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	329	57	plus	plus	CC
cord-017764-h1w9gbxk	329	58	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	329	59	in	in	IN
cord-017764-h1w9gbxk	329	60	elderly	elderly	JJ
cord-017764-h1w9gbxk	329	61	and	and	CC
cord-017764-h1w9gbxk	329	62	cirrhotic	cirrhotic	JJ
cord-017764-h1w9gbxk	329	63	patients	patient	NNS
cord-017764-h1w9gbxk	329	64	with	with	IN
cord-017764-h1w9gbxk	329	65	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	329	66	C	C	NNP
cord-017764-h1w9gbxk	329	67	virus	virus	NN
cord-017764-h1w9gbxk	329	68	genotype	genotype	NN
cord-017764-h1w9gbxk	329	69	1b	1b	CD
cord-017764-h1w9gbxk	329	70	without	without	IN
cord-017764-h1w9gbxk	329	71	baseline	baseline	JJ
cord-017764-h1w9gbxk	329	72	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	329	73	polymorphisms	polymorphism	NNS
cord-017764-h1w9gbxk	329	74	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	329	75	plus	plus	CC
cord-017764-h1w9gbxk	329	76	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	329	77	treatment	treatment	NN
cord-017764-h1w9gbxk	329	78	for	for	IN
cord-017764-h1w9gbxk	329	79	real	real	JJ
cord-017764-h1w9gbxk	329	80	-	-	HYPH
cord-017764-h1w9gbxk	329	81	world	world	NN
cord-017764-h1w9gbxk	329	82	HCV	HCV	NNP
cord-017764-h1w9gbxk	329	83	genotype	genotype	NN
cord-017764-h1w9gbxk	330	1	1-infected	1-infected	CD
cord-017764-h1w9gbxk	330	2	patients	patient	NNS
cord-017764-h1w9gbxk	330	3	in	in	IN
cord-017764-h1w9gbxk	330	4	Japan	Japan	NNP
cord-017764-h1w9gbxk	330	5	Randomized	randomized	JJ
cord-017764-h1w9gbxk	330	6	comparison	comparison	NN
cord-017764-h1w9gbxk	330	7	of	of	IN
cord-017764-h1w9gbxk	330	8	daclatasvir+asunaprevir	daclatasvir+asunaprevir	NNP
cord-017764-h1w9gbxk	330	9	versus	versus	IN
cord-017764-h1w9gbxk	330	10	telaprevir+peginterferon/	telaprevir+peginterferon/	NNP
cord-017764-h1w9gbxk	330	11	ribavirin	ribavirin	NNP
cord-017764-h1w9gbxk	330	12	in	in	IN
cord-017764-h1w9gbxk	330	13	Japanese	japanese	JJ
cord-017764-h1w9gbxk	330	14	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	330	15	C	c	NN
cord-017764-h1w9gbxk	330	16	virus	virus	NN
cord-017764-h1w9gbxk	330	17	patients	patient	NNS
cord-017764-h1w9gbxk	331	1	Favorable	favorable	JJ
cord-017764-h1w9gbxk	331	2	efficacy	efficacy	NN
cord-017764-h1w9gbxk	331	3	of	of	IN
cord-017764-h1w9gbxk	331	4	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	331	5	plus	plus	CC
cord-017764-h1w9gbxk	331	6	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	331	7	in	in	IN
cord-017764-h1w9gbxk	331	8	treatment	treatment	NN
cord-017764-h1w9gbxk	331	9	of	of	IN
cord-017764-h1w9gbxk	331	10	elderly	elderly	JJ
cord-017764-h1w9gbxk	331	11	Japanese	japanese	JJ
cord-017764-h1w9gbxk	331	12	patients	patient	NNS
cord-017764-h1w9gbxk	331	13	infected	infect	VBN
cord-017764-h1w9gbxk	331	14	with	with	IN
cord-017764-h1w9gbxk	331	15	HCV	HCV	NNP
cord-017764-h1w9gbxk	331	16	genotype	genotype	NN
cord-017764-h1w9gbxk	331	17	1b	1b	NN
cord-017764-h1w9gbxk	331	18	aged	age	VBN
cord-017764-h1w9gbxk	331	19	70	70	CD
cord-017764-h1w9gbxk	331	20	and	and	CC
cord-017764-h1w9gbxk	331	21	older	old	JJR
cord-017764-h1w9gbxk	331	22	Efficacy	efficacy	NN
cord-017764-h1w9gbxk	331	23	and	and	CC
cord-017764-h1w9gbxk	331	24	tolerability	tolerability	NN
cord-017764-h1w9gbxk	331	25	of	of	IN
cord-017764-h1w9gbxk	331	26	an	an	DT
cord-017764-h1w9gbxk	331	27	IFN	IFN	NNP
cord-017764-h1w9gbxk	331	28	-	-	HYPH
cord-017764-h1w9gbxk	331	29	free	free	JJ
cord-017764-h1w9gbxk	331	30	regimen	regimen	NN
cord-017764-h1w9gbxk	331	31	with	with	IN
cord-017764-h1w9gbxk	331	32	DCV	DCV	NNP
cord-017764-h1w9gbxk	331	33	/	/	SYM
cord-017764-h1w9gbxk	331	34	ASV	ASV	NNP
cord-017764-h1w9gbxk	331	35	for	for	IN
cord-017764-h1w9gbxk	331	36	elderly	elderly	JJ
cord-017764-h1w9gbxk	331	37	patients	patient	NNS
cord-017764-h1w9gbxk	331	38	infected	infect	VBN
cord-017764-h1w9gbxk	331	39	with	with	IN
cord-017764-h1w9gbxk	331	40	HCV	HCV	NNP
cord-017764-h1w9gbxk	331	41	genotype	genotype	NN
cord-017764-h1w9gbxk	331	42	1B	1b	CD
cord-017764-h1w9gbxk	332	1	The	the	DT
cord-017764-h1w9gbxk	332	2	efficacy	efficacy	NN
cord-017764-h1w9gbxk	332	3	and	and	CC
cord-017764-h1w9gbxk	332	4	safety	safety	NN
cord-017764-h1w9gbxk	332	5	of	of	IN
cord-017764-h1w9gbxk	332	6	dual	dual	JJ
cord-017764-h1w9gbxk	332	7	oral	oral	JJ
cord-017764-h1w9gbxk	332	8	therapy	therapy	NN
cord-017764-h1w9gbxk	332	9	with	with	IN
cord-017764-h1w9gbxk	332	10	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	332	11	and	and	CC
cord-017764-h1w9gbxk	332	12	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	332	13	for	for	IN
cord-017764-h1w9gbxk	332	14	genotype	genotype	NN
cord-017764-h1w9gbxk	332	15	1b	1b	CD
cord-017764-h1w9gbxk	332	16	in	in	IN
cord-017764-h1w9gbxk	332	17	Japanese	japanese	JJ
cord-017764-h1w9gbxk	332	18	real	real	JJ
cord-017764-h1w9gbxk	332	19	-	-	HYPH
cord-017764-h1w9gbxk	332	20	life	life	NN
cord-017764-h1w9gbxk	332	21	settings	setting	NNS
cord-017764-h1w9gbxk	333	1	The	the	DT
cord-017764-h1w9gbxk	333	2	practical	practical	JJ
cord-017764-h1w9gbxk	333	3	management	management	NN
cord-017764-h1w9gbxk	333	4	of	of	IN
cord-017764-h1w9gbxk	333	5	chronic	chronic	JJ
cord-017764-h1w9gbxk	333	6	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	333	7	C	c	NN
cord-017764-h1w9gbxk	333	8	infection	infection	NN
cord-017764-h1w9gbxk	333	9	in	in	IN
cord-017764-h1w9gbxk	333	10	Japan	Japan	NNP
cord-017764-h1w9gbxk	333	11	-dual	-dual	JJ
cord-017764-h1w9gbxk	333	12	therapy	therapy	NN
cord-017764-h1w9gbxk	333	13	of	of	IN
cord-017764-h1w9gbxk	333	14	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	333	15	+	+	CC
cord-017764-h1w9gbxk	334	1	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	335	1	The	the	DT
cord-017764-h1w9gbxk	335	2	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	335	3	and	and	CC
cord-017764-h1w9gbxk	335	4	Development	Development	NNP
cord-017764-h1w9gbxk	335	5	of	of	IN
cord-017764-h1w9gbxk	335	6	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	335	7	:	:	:
cord-017764-h1w9gbxk	336	1	An	an	DT
cord-017764-h1w9gbxk	336	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	336	3	of	of	IN
cord-017764-h1w9gbxk	336	4	the	the	DT
cord-017764-h1w9gbxk	336	5	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	336	6	for	for	IN
cord-017764-h1w9gbxk	336	7	the	the	DT
cord-017764-h1w9gbxk	336	8	treatment	treatment	NN
cord-017764-h1w9gbxk	336	9	of	of	IN
cord-017764-h1w9gbxk	336	10	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	336	11	C	C	NNP
cord-017764-h1w9gbxk	336	12	virus	virus	NN
cord-017764-h1w9gbxk	336	13	infection	infection	NN
cord-017764-h1w9gbxk	336	14	Efficacy	Efficacy	NNP
cord-017764-h1w9gbxk	336	15	and	and	CC
cord-017764-h1w9gbxk	336	16	safety	safety	NN
cord-017764-h1w9gbxk	336	17	of	of	IN
cord-017764-h1w9gbxk	336	18	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	336	19	in	in	IN
cord-017764-h1w9gbxk	336	20	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	336	21	C	C	NNP
cord-017764-h1w9gbxk	336	22	:	:	:
cord-017764-h1w9gbxk	336	23	an	an	DT
cord-017764-h1w9gbxk	336	24	overview	overview	NN
cord-017764-h1w9gbxk	336	25	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	336	26	and	and	CC
cord-017764-h1w9gbxk	336	27	preclinical	preclinical	JJ
cord-017764-h1w9gbxk	336	28	characterization	characterization	NN
cord-017764-h1w9gbxk	336	29	of	of	IN
cord-017764-h1w9gbxk	336	30	the	the	DT
cord-017764-h1w9gbxk	336	31	cyclopropylindolobenzazepine	cyclopropylindolobenzazepine	NN
cord-017764-h1w9gbxk	336	32	BMS-791325	BMS-791325	NNP
cord-017764-h1w9gbxk	336	33	,	,	,
cord-017764-h1w9gbxk	336	34	a	a	DT
cord-017764-h1w9gbxk	336	35	potent	potent	JJ
cord-017764-h1w9gbxk	336	36	allosteric	allosteric	JJ
cord-017764-h1w9gbxk	336	37	inhibitor	inhibitor	NN
cord-017764-h1w9gbxk	336	38	of	of	IN
cord-017764-h1w9gbxk	336	39	the	the	DT
cord-017764-h1w9gbxk	336	40	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	336	41	C	C	NNP
cord-017764-h1w9gbxk	336	42	virus	virus	NN
cord-017764-h1w9gbxk	336	43	NS5B	ns5b	CD
cord-017764-h1w9gbxk	336	44	polymerase	polymerase	NN
cord-017764-h1w9gbxk	336	45	UNITY-1	UNITY-1	NNP
cord-017764-h1w9gbxk	336	46	Study	Study	NNP
cord-017764-h1w9gbxk	336	47	Group	Group	NNP
cord-017764-h1w9gbxk	336	48	(	(	-LRB-
cord-017764-h1w9gbxk	336	49	2013	2013	CD
cord-017764-h1w9gbxk	336	50	)	)	-RRB-
cord-017764-h1w9gbxk	337	1	Fixed	fix	VBN
cord-017764-h1w9gbxk	337	2	-	-	HYPH
cord-017764-h1w9gbxk	337	3	dose	dose	NN
cord-017764-h1w9gbxk	337	4	combination	combination	NN
cord-017764-h1w9gbxk	337	5	therapy	therapy	NN
cord-017764-h1w9gbxk	337	6	with	with	IN
cord-017764-h1w9gbxk	337	7	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	337	8	,	,	,
cord-017764-h1w9gbxk	337	9	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	337	10	,	,	,
cord-017764-h1w9gbxk	337	11	and	and	CC
cord-017764-h1w9gbxk	337	12	beclabuvir	beclabuvir	NNP
cord-017764-h1w9gbxk	337	13	for	for	IN
cord-017764-h1w9gbxk	337	14	noncirrhotic	noncirrhotic	JJ
cord-017764-h1w9gbxk	337	15	patients	patient	NNS
cord-017764-h1w9gbxk	337	16	with	with	IN
cord-017764-h1w9gbxk	337	17	HCV	HCV	NNP
cord-017764-h1w9gbxk	337	18	genotype	genotype	NN
cord-017764-h1w9gbxk	337	19	1	1	CD
cord-017764-h1w9gbxk	337	20	infection	infection	NN
cord-017764-h1w9gbxk	337	21	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	337	22	in	in	IN
cord-017764-h1w9gbxk	337	23	combination	combination	NN
cord-017764-h1w9gbxk	337	24	with	with	IN
cord-017764-h1w9gbxk	337	25	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	337	26	and	and	CC
cord-017764-h1w9gbxk	337	27	beclabuvir	beclabuvir	NNP
cord-017764-h1w9gbxk	337	28	for	for	IN
cord-017764-h1w9gbxk	337	29	hepatitis	hepatitis	NNP
cord-017764-h1w9gbxk	337	30	C	C	NNP
cord-017764-h1w9gbxk	337	31	virus	virus	NN
cord-017764-h1w9gbxk	337	32	genotype	genotype	NN
cord-017764-h1w9gbxk	337	33	1	1	CD
cord-017764-h1w9gbxk	337	34	infection	infection	NN
cord-017764-h1w9gbxk	337	35	with	with	IN
cord-017764-h1w9gbxk	337	36	compensated	compensate	VBN
cord-017764-h1w9gbxk	337	37	cirrhosis	cirrhosis	NN
cord-017764-h1w9gbxk	338	1	A	a	DT
cord-017764-h1w9gbxk	338	2	randomized	randomized	JJ
cord-017764-h1w9gbxk	338	3	trial	trial	NN
cord-017764-h1w9gbxk	338	4	of	of	IN
cord-017764-h1w9gbxk	338	5	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	338	6	in	in	IN
cord-017764-h1w9gbxk	338	7	combination	combination	NN
cord-017764-h1w9gbxk	338	8	with	with	IN
cord-017764-h1w9gbxk	338	9	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	338	10	and	and	CC
cord-017764-h1w9gbxk	338	11	beclabuvir	beclabuvir	NNS
cord-017764-h1w9gbxk	338	12	in	in	IN
cord-017764-h1w9gbxk	338	13	patients	patient	NNS
cord-017764-h1w9gbxk	338	14	with	with	IN
cord-017764-h1w9gbxk	338	15	chronic	chronic	JJ
cord-017764-h1w9gbxk	338	16	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	338	17	C	c	NN
cord-017764-h1w9gbxk	338	18	virus	virus	NN
cord-017764-h1w9gbxk	338	19	genotype	genotype	NN
cord-017764-h1w9gbxk	338	20	4	4	CD
cord-017764-h1w9gbxk	338	21	infection	infection	NN
cord-017764-h1w9gbxk	339	1	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	339	2	/	/	SYM
cord-017764-h1w9gbxk	339	3	asunaprevir/	asunaprevir/	CD
cord-017764-h1w9gbxk	339	4	beclabuvir	beclabuvir	NNS
cord-017764-h1w9gbxk	339	5	fixed	fix	VBN
cord-017764-h1w9gbxk	339	6	-	-	HYPH
cord-017764-h1w9gbxk	339	7	dose	dose	NN
cord-017764-h1w9gbxk	339	8	combination	combination	NN
cord-017764-h1w9gbxk	339	9	in	in	IN
cord-017764-h1w9gbxk	339	10	Japanese	japanese	JJ
cord-017764-h1w9gbxk	339	11	patients	patient	NNS
cord-017764-h1w9gbxk	339	12	with	with	IN
cord-017764-h1w9gbxk	339	13	HCV	HCV	NNP
cord-017764-h1w9gbxk	339	14	genotype	genotype	NN
cord-017764-h1w9gbxk	339	15	1	1	CD
cord-017764-h1w9gbxk	339	16	infection	infection	NN
cord-017764-h1w9gbxk	340	1	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	340	2	/	/	SYM
cord-017764-h1w9gbxk	340	3	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	340	4	/	/	SYM
cord-017764-h1w9gbxk	340	5	beclabuvir	beclabuvir	NNS
cord-017764-h1w9gbxk	340	6	,	,	,
cord-017764-h1w9gbxk	340	7	all	all	RB
cord-017764-h1w9gbxk	340	8	-	-	HYPH
cord-017764-h1w9gbxk	340	9	oral	oral	JJ
cord-017764-h1w9gbxk	340	10	,	,	,
cord-017764-h1w9gbxk	340	11	fixed	fix	VBN
cord-017764-h1w9gbxk	340	12	-	-	HYPH
cord-017764-h1w9gbxk	340	13	dose	dose	NN
cord-017764-h1w9gbxk	340	14	combination	combination	NN
cord-017764-h1w9gbxk	340	15	for	for	IN
cord-017764-h1w9gbxk	340	16	patients	patient	NNS
cord-017764-h1w9gbxk	340	17	with	with	IN
cord-017764-h1w9gbxk	340	18	chronic	chronic	JJ
cord-017764-h1w9gbxk	340	19	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	20	C	C	NNP
cord-017764-h1w9gbxk	340	21	virus	virus	NN
cord-017764-h1w9gbxk	340	22	genotype	genotype	NN
cord-017764-h1w9gbxk	340	23	1	1	CD
cord-017764-h1w9gbxk	340	24	Beclabuvir	Beclabuvir	NNP
cord-017764-h1w9gbxk	340	25	in	in	IN
cord-017764-h1w9gbxk	340	26	combination	combination	NN
cord-017764-h1w9gbxk	340	27	with	with	IN
cord-017764-h1w9gbxk	340	28	asunaprevir	asunaprevir	NNS
cord-017764-h1w9gbxk	340	29	and	and	CC
cord-017764-h1w9gbxk	340	30	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	340	31	for	for	IN
cord-017764-h1w9gbxk	340	32	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	33	C	C	NNP
cord-017764-h1w9gbxk	340	34	virus	virus	NN
cord-017764-h1w9gbxk	340	35	genotype	genotype	NN
cord-017764-h1w9gbxk	340	36	1	1	CD
cord-017764-h1w9gbxk	340	37	infection	infection	NN
cord-017764-h1w9gbxk	340	38	:	:	:
cord-017764-h1w9gbxk	340	39	a	a	DT
cord-017764-h1w9gbxk	340	40	systematic	systematic	JJ
cord-017764-h1w9gbxk	340	41	review	review	NN
cord-017764-h1w9gbxk	340	42	and	and	CC
cord-017764-h1w9gbxk	340	43	meta	meta	NNP
cord-017764-h1w9gbxk	340	44	-	-	HYPH
cord-017764-h1w9gbxk	340	45	analysis	analysis	NN
cord-017764-h1w9gbxk	340	46	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	340	47	with	with	IN
cord-017764-h1w9gbxk	340	48	sofosbuvir	sofosbuvir	NN
cord-017764-h1w9gbxk	340	49	and	and	CC
cord-017764-h1w9gbxk	340	50	ribavirin	ribavirin	NN
cord-017764-h1w9gbxk	340	51	for	for	IN
cord-017764-h1w9gbxk	340	52	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	53	C	C	NNP
cord-017764-h1w9gbxk	340	54	virus	virus	NN
cord-017764-h1w9gbxk	340	55	infection	infection	NN
cord-017764-h1w9gbxk	340	56	with	with	IN
cord-017764-h1w9gbxk	340	57	advanced	advanced	JJ
cord-017764-h1w9gbxk	340	58	cirrhosis	cirrhosis	NN
cord-017764-h1w9gbxk	340	59	or	or	CC
cord-017764-h1w9gbxk	340	60	post	post	JJ
cord-017764-h1w9gbxk	340	61	-	-	JJ
cord-017764-h1w9gbxk	340	62	liver	liver	JJ
cord-017764-h1w9gbxk	340	63	transplantation	transplantation	NN
cord-017764-h1w9gbxk	340	64	recurrence	recurrence	NN
cord-017764-h1w9gbxk	340	65	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	340	66	plus	plus	CC
cord-017764-h1w9gbxk	340	67	sofosbuvir	sofosbuvir	NN
cord-017764-h1w9gbxk	340	68	for	for	IN
cord-017764-h1w9gbxk	340	69	HCV	HCV	NNP
cord-017764-h1w9gbxk	340	70	in	in	IN
cord-017764-h1w9gbxk	340	71	patients	patient	NNS
cord-017764-h1w9gbxk	340	72	coinfected	coinfecte	VBD
cord-017764-h1w9gbxk	340	73	with	with	IN
cord-017764-h1w9gbxk	340	74	HIV-1	HIV-1	NNP
cord-017764-h1w9gbxk	340	75	All	all	RB
cord-017764-h1w9gbxk	340	76	-	-	HYPH
cord-017764-h1w9gbxk	340	77	oral	oral	JJ
cord-017764-h1w9gbxk	340	78	12-week	12-week	JJ
cord-017764-h1w9gbxk	340	79	treatment	treatment	NN
cord-017764-h1w9gbxk	340	80	with	with	IN
cord-017764-h1w9gbxk	340	81	daclatasvir	daclatasvir	NNP
cord-017764-h1w9gbxk	340	82	plus	plus	CC
cord-017764-h1w9gbxk	340	83	sofosbuvir	sofosbuvir	NN
cord-017764-h1w9gbxk	340	84	in	in	IN
cord-017764-h1w9gbxk	340	85	patients	patient	NNS
cord-017764-h1w9gbxk	340	86	with	with	IN
cord-017764-h1w9gbxk	340	87	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	88	C	C	NNP
cord-017764-h1w9gbxk	340	89	virus	virus	NN
cord-017764-h1w9gbxk	340	90	genotype	genotype	NN
cord-017764-h1w9gbxk	340	91	3	3	CD
cord-017764-h1w9gbxk	340	92	infection	infection	NN
cord-017764-h1w9gbxk	340	93	:	:	:
cord-017764-h1w9gbxk	340	94	ALLY-3	ALLY-3	NNP
cord-017764-h1w9gbxk	340	95	phase	phase	NN
cord-017764-h1w9gbxk	340	96	III	iii	CD
cord-017764-h1w9gbxk	340	97	study	study	NN
cord-017764-h1w9gbxk	340	98	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	340	99	plus	plus	CC
cord-017764-h1w9gbxk	340	100	sofobuvir	sofobuvir	NNS
cord-017764-h1w9gbxk	340	101	,	,	,
cord-017764-h1w9gbxk	340	102	with	with	IN
cord-017764-h1w9gbxk	340	103	and	and	CC
cord-017764-h1w9gbxk	340	104	without	without	IN
cord-017764-h1w9gbxk	340	105	ribavirin	ribavirin	NN
cord-017764-h1w9gbxk	340	106	,	,	,
cord-017764-h1w9gbxk	340	107	achieved	achieve	VBD
cord-017764-h1w9gbxk	340	108	high	high	RB
cord-017764-h1w9gbxk	340	109	sustained	sustained	JJ
cord-017764-h1w9gbxk	340	110	virological	virological	JJ
cord-017764-h1w9gbxk	340	111	response	response	NN
cord-017764-h1w9gbxk	340	112	rates	rate	NNS
cord-017764-h1w9gbxk	340	113	in	in	IN
cord-017764-h1w9gbxk	340	114	patients	patient	NNS
cord-017764-h1w9gbxk	340	115	with	with	IN
cord-017764-h1w9gbxk	340	116	HCV	HCV	NNP
cord-017764-h1w9gbxk	340	117	infection	infection	NN
cord-017764-h1w9gbxk	340	118	and	and	CC
cord-017764-h1w9gbxk	340	119	advanced	advanced	JJ
cord-017764-h1w9gbxk	340	120	liver	liver	NN
cord-017764-h1w9gbxk	340	121	disease	disease	NN
cord-017764-h1w9gbxk	340	122	in	in	IN
cord-017764-h1w9gbxk	340	123	a	a	DT
cord-017764-h1w9gbxk	340	124	real	real	JJ
cord-017764-h1w9gbxk	340	125	-	-	HYPH
cord-017764-h1w9gbxk	340	126	world	world	NN
cord-017764-h1w9gbxk	340	127	cohort	cohort	NN
cord-017764-h1w9gbxk	340	128	Long	long	JJ
cord-017764-h1w9gbxk	340	129	-	-	HYPH
cord-017764-h1w9gbxk	340	130	term	term	NN
cord-017764-h1w9gbxk	340	131	follow	follow	NN
cord-017764-h1w9gbxk	340	132	-	-	HYPH
cord-017764-h1w9gbxk	340	133	up	up	NN
cord-017764-h1w9gbxk	340	134	of	of	IN
cord-017764-h1w9gbxk	340	135	clinical	clinical	JJ
cord-017764-h1w9gbxk	340	136	trial	trial	NN
cord-017764-h1w9gbxk	340	137	patients	patient	NNS
cord-017764-h1w9gbxk	340	138	treated	treat	VBN
cord-017764-h1w9gbxk	340	139	for	for	IN
cord-017764-h1w9gbxk	340	140	chronic	chronic	JJ
cord-017764-h1w9gbxk	340	141	HCV	HCV	NNP
cord-017764-h1w9gbxk	340	142	infection	infection	NN
cord-017764-h1w9gbxk	340	143	with	with	IN
cord-017764-h1w9gbxk	340	144	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	340	145	-	-	HYPH
cord-017764-h1w9gbxk	340	146	based	base	VBN
cord-017764-h1w9gbxk	340	147	regimens	regimen	NNS
cord-017764-h1w9gbxk	340	148	Current	current	JJ
cord-017764-h1w9gbxk	340	149	therapy	therapy	NN
cord-017764-h1w9gbxk	340	150	for	for	IN
cord-017764-h1w9gbxk	340	151	chronic	chronic	JJ
cord-017764-h1w9gbxk	340	152	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	153	C	c	NN
cord-017764-h1w9gbxk	340	154	:	:	:
cord-017764-h1w9gbxk	340	155	the	the	DT
cord-017764-h1w9gbxk	340	156	role	role	NN
cord-017764-h1w9gbxk	340	157	of	of	IN
cord-017764-h1w9gbxk	340	158	direct	direct	JJ
cord-017764-h1w9gbxk	340	159	-	-	HYPH
cord-017764-h1w9gbxk	340	160	acting	act	VBG
cord-017764-h1w9gbxk	340	161	antivirals	antiviral	NNS
cord-017764-h1w9gbxk	340	162	Short	short	JJ
cord-017764-h1w9gbxk	340	163	-	-	HYPH
cord-017764-h1w9gbxk	340	164	duration	duration	NN
cord-017764-h1w9gbxk	340	165	treatment	treatment	NN
cord-017764-h1w9gbxk	340	166	for	for	IN
cord-017764-h1w9gbxk	340	167	chronic	chronic	JJ
cord-017764-h1w9gbxk	340	168	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	340	169	C	C	NNP
cord-017764-h1w9gbxk	340	170	virus	virus	NN
cord-017764-h1w9gbxk	340	171	with	with	IN
cord-017764-h1w9gbxk	340	172	daclatasvir	daclatasvir	NNS
cord-017764-h1w9gbxk	340	173	,	,	,
cord-017764-h1w9gbxk	340	174	asunaprevir	asunaprevir	NNP
cord-017764-h1w9gbxk	340	175	,	,	,
cord-017764-h1w9gbxk	340	176	beclabuvir	beclabuvir	NNP
cord-017764-h1w9gbxk	340	177	and	and	CC
cord-017764-h1w9gbxk	340	178	sofosbuvir	sofosbuvir	NNP
cord-017764-h1w9gbxk	340	179	(	(	-LRB-
cord-017764-h1w9gbxk	340	180	FOURward	FOURward	NNP
cord-017764-h1w9gbxk	340	181	study	study	NN
cord-017764-h1w9gbxk	340	182	)	)	-RRB-
cord-017764-h1w9gbxk	341	1	Daclatasvir	Daclatasvir	NNS
cord-017764-h1w9gbxk	341	2	:	:	:
cord-017764-h1w9gbxk	341	3	the	the	DT
cord-017764-h1w9gbxk	341	4	first	first	JJ
cord-017764-h1w9gbxk	341	5	of	of	IN
cord-017764-h1w9gbxk	341	6	a	a	DT
cord-017764-h1w9gbxk	341	7	new	new	JJ
cord-017764-h1w9gbxk	341	8	class	class	NN
cord-017764-h1w9gbxk	341	9	of	of	IN
cord-017764-h1w9gbxk	341	10	drugs	drug	NNS
cord-017764-h1w9gbxk	341	11	targeted	target	VBN
cord-017764-h1w9gbxk	341	12	against	against	IN
cord-017764-h1w9gbxk	341	13	hepatitis	hepatitis	NN
cord-017764-h1w9gbxk	341	14	C	C	NNP
cord-017764-h1w9gbxk	341	15	virus	virus	NN
cord-017764-h1w9gbxk	342	1	NS5A	NS5A	NNP
cord-017764-h1w9gbxk	343	1	How	how	WRB
cord-017764-h1w9gbxk	343	2	were	be	VBD
cord-017764-h1w9gbxk	343	3	new	new	JJ
cord-017764-h1w9gbxk	343	4	medicines	medicine	NNS
cord-017764-h1w9gbxk	343	5	discovered	discover	VBN
cord-017764-h1w9gbxk	343	6	?	?	.
cord-017764-h1w9gbxk	344	1	Impact	impact	NN
cord-017764-h1w9gbxk	344	2	of	of	IN
cord-017764-h1w9gbxk	344	3	highthroughput	highthroughput	NN
cord-017764-h1w9gbxk	344	4	screening	screening	NN
cord-017764-h1w9gbxk	344	5	on	on	IN
cord-017764-h1w9gbxk	344	6	biomedical	biomedical	JJ
cord-017764-h1w9gbxk	344	7	research	research	NN
cord-017764-h1w9gbxk	344	8	Cell	cell	NN
cord-017764-h1w9gbxk	344	9	-	-	HYPH
cord-017764-h1w9gbxk	344	10	based	base	VBN
cord-017764-h1w9gbxk	344	11	assays	assay	NNS
cord-017764-h1w9gbxk	344	12	to	to	TO
cord-017764-h1w9gbxk	344	13	identify	identify	VB
cord-017764-h1w9gbxk	344	14	inhibitors	inhibitor	NNS
cord-017764-h1w9gbxk	344	15	of	of	IN
cord-017764-h1w9gbxk	344	16	viral	viral	JJ
cord-017764-h1w9gbxk	344	17	disease	disease	NN
cord-017764-h1w9gbxk	344	18	Anti	Anti	NNP
cord-017764-h1w9gbxk	344	19	-	-	NNP
cord-017764-h1w9gbxk	344	20	infectives	infectives	NNP
cord-017764-h1w9gbxk	344	21	:	:	:
cord-017764-h1w9gbxk	344	22	can	can	MD
cord-017764-h1w9gbxk	344	23	cellular	cellular	JJ
cord-017764-h1w9gbxk	344	24	screening	screening	NN
cord-017764-h1w9gbxk	344	25	deliver	deliver	VB
cord-017764-h1w9gbxk	344	26	?	?	.
cord-017764-h1w9gbxk	345	1	The	the	DT
cord-017764-h1w9gbxk	345	2	Discovery	Discovery	NNP
cord-017764-h1w9gbxk	345	3	and	and	CC
cord-017764-h1w9gbxk	345	4	Development	Development	NNP
cord-017764-h1w9gbxk	345	5	of	of	IN
cord-017764-h1w9gbxk	345	6	Daclatasvir	Daclatasvir	NNP
cord-017764-h1w9gbxk	345	7	:	:	:
cord-017764-h1w9gbxk	346	1	An	an	DT
cord-017764-h1w9gbxk	346	2	Inhibitor	Inhibitor	NNP
cord-017764-h1w9gbxk	346	3	of	of	IN
cord-017764-h1w9gbxk	346	4	the	the	DT