id	sid	tid	token	lemma	pos
cord-280878-1kt51viz	1	1	key	key	JJ
cord-280878-1kt51viz	1	2	:	:	:
cord-280878-1kt51viz	1	3	cord-280878	cord-280878	NN
cord-280878-1kt51viz	1	4	-	-	HYPH
cord-280878-1kt51viz	1	5	1kt51viz	1kt51viz	CD
cord-280878-1kt51viz	1	6	authors	author	NNS
cord-280878-1kt51viz	1	7	:	:	:
cord-280878-1kt51viz	2	1	To	to	TO
cord-280878-1kt51viz	2	2	,	,	,
cord-280878-1kt51viz	2	3	Janet	Janet	NNP
cord-280878-1kt51viz	2	4	;	;	:
cord-280878-1kt51viz	2	5	Surya	Surya	NNP
cord-280878-1kt51viz	2	6	,	,	,
cord-280878-1kt51viz	2	7	Wahyu	Wahyu	NNP
cord-280878-1kt51viz	2	8	;	;	:
cord-280878-1kt51viz	2	9	Torres	Torres	NNP
cord-280878-1kt51viz	2	10	,	,	,
cord-280878-1kt51viz	2	11	Jaume	Jaume	NNP
cord-280878-1kt51viz	2	12	title	title	NN
cord-280878-1kt51viz	2	13	:	:	:
cord-280878-1kt51viz	2	14	Targeting	target	VBG
cord-280878-1kt51viz	2	15	the	the	DT
cord-280878-1kt51viz	2	16	Channel	Channel	NNP
cord-280878-1kt51viz	2	17	Activity	Activity	NNP
cord-280878-1kt51viz	2	18	of	of	IN
cord-280878-1kt51viz	2	19	Viroporins	Viroporins	NNP
cord-280878-1kt51viz	2	20	date	date	NN
cord-280878-1kt51viz	2	21	:	:	:
cord-280878-1kt51viz	2	22	2016	2016	CD
cord-280878-1kt51viz	2	23	-	-	HYPH
cord-280878-1kt51viz	2	24	01	01	CD
cord-280878-1kt51viz	2	25	-	-	HYPH
cord-280878-1kt51viz	2	26	07	07	CD
cord-280878-1kt51viz	2	27	journal	journal	NN
cord-280878-1kt51viz	2	28	:	:	:
cord-280878-1kt51viz	3	1	Adv	Adv	NNP
cord-280878-1kt51viz	3	2	Protein	Protein	NNP
cord-280878-1kt51viz	3	3	Chem	Chem	NNP
cord-280878-1kt51viz	3	4	Struct	Struct	NNP
cord-280878-1kt51viz	3	5	Biol	Biol	NNP
cord-280878-1kt51viz	3	6	DOI	DOI	NNP
cord-280878-1kt51viz	3	7	:	:	:
cord-280878-1kt51viz	4	1	10.1016/	10.1016/	CD
cord-280878-1kt51viz	5	1	bs.apcsb.2015.12.003	bs.apcsb.2015.12.003	NNP
cord-280878-1kt51viz	5	2	sha	sha	NNP
cord-280878-1kt51viz	5	3	:	:	:
cord-280878-1kt51viz	6	1	bf25a09ac9c485d7d8d40a9fd9c2caecb1936a13	bf25a09ac9c485d7d8d40a9fd9c2caecb1936a13	NNP
cord-280878-1kt51viz	6	2	doc_id	doc_id	NNP
cord-280878-1kt51viz	6	3	:	:	:
cord-280878-1kt51viz	6	4	280878	280878	CD
cord-280878-1kt51viz	6	5	cord_uid	cord_uid	NNS
cord-280878-1kt51viz	6	6	:	:	:
cord-280878-1kt51viz	6	7	1kt51viz	1kt51viz	CD
cord-280878-1kt51viz	7	1	Since	since	IN
cord-280878-1kt51viz	7	2	the	the	DT
cord-280878-1kt51viz	7	3	discovery	discovery	NN
cord-280878-1kt51viz	7	4	that	that	IN
cord-280878-1kt51viz	7	5	certain	certain	JJ
cord-280878-1kt51viz	7	6	small	small	JJ
cord-280878-1kt51viz	7	7	viral	viral	JJ
cord-280878-1kt51viz	7	8	membrane	membrane	NN
cord-280878-1kt51viz	7	9	proteins	protein	NNS
cord-280878-1kt51viz	7	10	,	,	,
cord-280878-1kt51viz	7	11	collectively	collectively	RB
cord-280878-1kt51viz	7	12	termed	term	VBN
cord-280878-1kt51viz	7	13	as	as	IN
cord-280878-1kt51viz	7	14	viroporins	viroporin	NNS
cord-280878-1kt51viz	7	15	,	,	,
cord-280878-1kt51viz	7	16	can	can	MD
cord-280878-1kt51viz	7	17	permeabilize	permeabilize	NNP
cord-280878-1kt51viz	7	18	host	host	NN
cord-280878-1kt51viz	7	19	cellular	cellular	JJ
cord-280878-1kt51viz	7	20	membranes	membrane	NNS
cord-280878-1kt51viz	7	21	and	and	CC
cord-280878-1kt51viz	7	22	also	also	RB
cord-280878-1kt51viz	7	23	behave	behave	VB
cord-280878-1kt51viz	7	24	as	as	IN
cord-280878-1kt51viz	7	25	ion	ion	NN
cord-280878-1kt51viz	7	26	channels	channel	NNS
cord-280878-1kt51viz	7	27	,	,	,
cord-280878-1kt51viz	7	28	attempts	attempt	NNS
cord-280878-1kt51viz	7	29	have	have	VBP
cord-280878-1kt51viz	7	30	been	be	VBN
cord-280878-1kt51viz	7	31	made	make	VBN
cord-280878-1kt51viz	7	32	to	to	TO
cord-280878-1kt51viz	7	33	link	link	VB
cord-280878-1kt51viz	7	34	this	this	DT
cord-280878-1kt51viz	7	35	feature	feature	NN
cord-280878-1kt51viz	7	36	to	to	IN
cord-280878-1kt51viz	7	37	specific	specific	JJ
cord-280878-1kt51viz	7	38	biological	biological	JJ
cord-280878-1kt51viz	7	39	roles	role	NNS
cord-280878-1kt51viz	7	40	.	.	.
cord-280878-1kt51viz	8	1	In	in	IN
cord-280878-1kt51viz	8	2	parallel	parallel	JJ
cord-280878-1kt51viz	8	3	,	,	,
cord-280878-1kt51viz	8	4	most	most	JJS
cord-280878-1kt51viz	8	5	viroporins	viroporin	NNS
cord-280878-1kt51viz	8	6	identified	identify	VBN
cord-280878-1kt51viz	8	7	so	so	RB
cord-280878-1kt51viz	8	8	far	far	RB
cord-280878-1kt51viz	8	9	are	be	VBP
cord-280878-1kt51viz	8	10	virulence	virulence	NN
cord-280878-1kt51viz	8	11	factors	factor	NNS
cord-280878-1kt51viz	8	12	,	,	,
cord-280878-1kt51viz	8	13	and	and	CC
cord-280878-1kt51viz	8	14	interest	interest	NN
cord-280878-1kt51viz	8	15	has	have	VBZ
cord-280878-1kt51viz	8	16	focused	focus	VBN
cord-280878-1kt51viz	8	17	toward	toward	IN
cord-280878-1kt51viz	8	18	the	the	DT
cord-280878-1kt51viz	8	19	discovery	discovery	NN
cord-280878-1kt51viz	8	20	of	of	IN
cord-280878-1kt51viz	8	21	channel	channel	NNP
cord-280878-1kt51viz	8	22	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	8	23	that	that	WDT
cord-280878-1kt51viz	8	24	would	would	MD
cord-280878-1kt51viz	8	25	have	have	VB
cord-280878-1kt51viz	8	26	a	a	DT
cord-280878-1kt51viz	8	27	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	8	28	effect	effect	NN
cord-280878-1kt51viz	8	29	,	,	,
cord-280878-1kt51viz	8	30	or	or	CC
cord-280878-1kt51viz	8	31	be	be	VB
cord-280878-1kt51viz	8	32	used	use	VBN
cord-280878-1kt51viz	8	33	as	as	IN
cord-280878-1kt51viz	8	34	research	research	NN
cord-280878-1kt51viz	8	35	tools	tool	NNS
cord-280878-1kt51viz	8	36	to	to	TO
cord-280878-1kt51viz	8	37	understand	understand	VB
cord-280878-1kt51viz	8	38	the	the	DT
cord-280878-1kt51viz	8	39	biological	biological	JJ
cord-280878-1kt51viz	8	40	roles	role	NNS
cord-280878-1kt51viz	8	41	of	of	IN
cord-280878-1kt51viz	8	42	viroporin	viroporin	NNP
cord-280878-1kt51viz	8	43	ion	ion	NN
cord-280878-1kt51viz	8	44	channel	channel	NN
cord-280878-1kt51viz	8	45	activity	activity	NN
cord-280878-1kt51viz	8	46	.	.	.
cord-280878-1kt51viz	9	1	However	however	RB
cord-280878-1kt51viz	9	2	,	,	,
cord-280878-1kt51viz	9	3	this	this	DT
cord-280878-1kt51viz	9	4	paradigm	paradigm	NN
cord-280878-1kt51viz	9	5	is	be	VBZ
cord-280878-1kt51viz	9	6	being	be	VBG
cord-280878-1kt51viz	9	7	shifted	shift	VBN
cord-280878-1kt51viz	9	8	by	by	IN
cord-280878-1kt51viz	9	9	the	the	DT
cord-280878-1kt51viz	9	10	difficulties	difficulty	NNS
cord-280878-1kt51viz	9	11	inherent	inherent	JJ
cord-280878-1kt51viz	9	12	to	to	IN
cord-280878-1kt51viz	9	13	small	small	JJ
cord-280878-1kt51viz	9	14	viral	viral	JJ
cord-280878-1kt51viz	9	15	membrane	membrane	NN
cord-280878-1kt51viz	9	16	proteins	protein	NNS
cord-280878-1kt51viz	9	17	,	,	,
cord-280878-1kt51viz	9	18	and	and	CC
cord-280878-1kt51viz	9	19	by	by	IN
cord-280878-1kt51viz	9	20	the	the	DT
cord-280878-1kt51viz	9	21	realization	realization	NN
cord-280878-1kt51viz	9	22	that	that	IN
cord-280878-1kt51viz	9	23	protein	protein	NN
cord-280878-1kt51viz	9	24	–	–	:
cord-280878-1kt51viz	9	25	protein	protein	NN
cord-280878-1kt51viz	9	26	interactions	interaction	NNS
cord-280878-1kt51viz	9	27	and	and	CC
cord-280878-1kt51viz	9	28	other	other	JJ
cord-280878-1kt51viz	9	29	diverse	diverse	JJ
cord-280878-1kt51viz	9	30	roles	role	NNS
cord-280878-1kt51viz	9	31	in	in	IN
cord-280878-1kt51viz	9	32	the	the	DT
cord-280878-1kt51viz	9	33	virus	virus	NN
cord-280878-1kt51viz	9	34	life	life	NN
cord-280878-1kt51viz	9	35	cycle	cycle	NN
cord-280878-1kt51viz	9	36	may	may	MD
cord-280878-1kt51viz	9	37	represent	represent	VB
cord-280878-1kt51viz	9	38	an	an	DT
cord-280878-1kt51viz	9	39	equal	equal	JJ
cord-280878-1kt51viz	9	40	,	,	,
cord-280878-1kt51viz	9	41	if	if	IN
cord-280878-1kt51viz	9	42	not	not	RB
cord-280878-1kt51viz	9	43	,	,	,
cord-280878-1kt51viz	9	44	more	more	RBR
cord-280878-1kt51viz	9	45	important	important	JJ
cord-280878-1kt51viz	9	46	target	target	NN
cord-280878-1kt51viz	9	47	.	.	.
cord-280878-1kt51viz	10	1	Therefore	therefore	RB
cord-280878-1kt51viz	10	2	,	,	,
cord-280878-1kt51viz	10	3	although	although	IN
cord-280878-1kt51viz	10	4	targeting	target	VBG
cord-280878-1kt51viz	10	5	the	the	DT
cord-280878-1kt51viz	10	6	channel	channel	NN
cord-280878-1kt51viz	10	7	activity	activity	NN
cord-280878-1kt51viz	10	8	of	of	IN
cord-280878-1kt51viz	10	9	viroporins	viroporin	NNS
cord-280878-1kt51viz	10	10	can	can	MD
cord-280878-1kt51viz	10	11	probably	probably	RB
cord-280878-1kt51viz	10	12	be	be	VB
cord-280878-1kt51viz	10	13	therapeutically	therapeutically	RB
cord-280878-1kt51viz	10	14	useful	useful	JJ
cord-280878-1kt51viz	10	15	in	in	IN
cord-280878-1kt51viz	10	16	some	some	DT
cord-280878-1kt51viz	10	17	cases	case	NNS
cord-280878-1kt51viz	10	18	,	,	,
cord-280878-1kt51viz	10	19	the	the	DT
cord-280878-1kt51viz	10	20	focus	focus	NN
cord-280878-1kt51viz	10	21	may	may	MD
cord-280878-1kt51viz	10	22	shift	shift	VB
cord-280878-1kt51viz	10	23	to	to	IN
cord-280878-1kt51viz	10	24	their	-PRON-	PRP$
cord-280878-1kt51viz	10	25	other	other	JJ
cord-280878-1kt51viz	10	26	functions	function	NNS
cord-280878-1kt51viz	10	27	in	in	IN
cord-280878-1kt51viz	10	28	following	follow	VBG
cord-280878-1kt51viz	10	29	years	year	NNS
cord-280878-1kt51viz	10	30	.	.	.
cord-280878-1kt51viz	11	1	Small	small	JJ
cord-280878-1kt51viz	11	2	-	-	HYPH
cord-280878-1kt51viz	11	3	molecule	molecule	NN
cord-280878-1kt51viz	11	4	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	11	5	have	have	VBP
cord-280878-1kt51viz	11	6	been	be	VBN
cord-280878-1kt51viz	11	7	mostly	mostly	RB
cord-280878-1kt51viz	11	8	developed	develop	VBN
cord-280878-1kt51viz	11	9	against	against	IN
cord-280878-1kt51viz	11	10	the	the	DT
cord-280878-1kt51viz	11	11	influenza	influenza	NN
cord-280878-1kt51viz	11	12	A	a	DT
cord-280878-1kt51viz	11	13	M2	M2	NNP
cord-280878-1kt51viz	11	14	(	(	-LRB-
cord-280878-1kt51viz	11	15	IAV	IAV	NNP
cord-280878-1kt51viz	11	16	M2	M2	NNP
cord-280878-1kt51viz	11	17	or	or	CC
cord-280878-1kt51viz	11	18	AM2	AM2	NNP
cord-280878-1kt51viz	11	19	)	)	-RRB-
cord-280878-1kt51viz	11	20	.	.	.
cord-280878-1kt51viz	12	1	This	this	DT
cord-280878-1kt51viz	12	2	is	be	VBZ
cord-280878-1kt51viz	12	3	not	not	RB
cord-280878-1kt51viz	12	4	surprising	surprising	JJ
cord-280878-1kt51viz	12	5	since	since	IN
cord-280878-1kt51viz	12	6	AM2	AM2	NNP
cord-280878-1kt51viz	12	7	is	be	VBZ
cord-280878-1kt51viz	12	8	the	the	DT
cord-280878-1kt51viz	12	9	best	well	RBS
cord-280878-1kt51viz	12	10	characterized	characterize	VBN
cord-280878-1kt51viz	12	11	viroporin	viroporin	NN
cord-280878-1kt51viz	12	12	to	to	IN
cord-280878-1kt51viz	12	13	date	date	NN
cord-280878-1kt51viz	12	14	,	,	,
cord-280878-1kt51viz	12	15	with	with	IN
cord-280878-1kt51viz	12	16	a	a	DT
cord-280878-1kt51viz	12	17	well	well	RB
cord-280878-1kt51viz	12	18	-	-	HYPH
cord-280878-1kt51viz	12	19	established	establish	VBN
cord-280878-1kt51viz	12	20	biological	biological	JJ
cord-280878-1kt51viz	12	21	role	role	NN
cord-280878-1kt51viz	12	22	in	in	IN
cord-280878-1kt51viz	12	23	viral	viral	JJ
cord-280878-1kt51viz	12	24	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	12	25	combined	combine	VBN
cord-280878-1kt51viz	12	26	the	the	DT
cord-280878-1kt51viz	12	27	most	most	RBS
cord-280878-1kt51viz	12	28	extensive	extensive	JJ
cord-280878-1kt51viz	12	29	structural	structural	JJ
cord-280878-1kt51viz	12	30	investigations	investigation	NNS
cord-280878-1kt51viz	12	31	conducted	conduct	VBN
cord-280878-1kt51viz	12	32	,	,	,
cord-280878-1kt51viz	12	33	and	and	CC
cord-280878-1kt51viz	12	34	has	have	VBZ
cord-280878-1kt51viz	12	35	emerged	emerge	VBN
cord-280878-1kt51viz	12	36	as	as	IN
cord-280878-1kt51viz	12	37	a	a	DT
cord-280878-1kt51viz	12	38	validated	validate	VBN
cord-280878-1kt51viz	12	39	drug	drug	NN
cord-280878-1kt51viz	12	40	target	target	NN
cord-280878-1kt51viz	12	41	.	.	.
cord-280878-1kt51viz	13	1	For	for	IN
cord-280878-1kt51viz	13	2	other	other	JJ
cord-280878-1kt51viz	13	3	viroporins	viroporin	NNS
cord-280878-1kt51viz	13	4	,	,	,
cord-280878-1kt51viz	13	5	these	these	DT
cord-280878-1kt51viz	13	6	studies	study	NNS
cord-280878-1kt51viz	13	7	are	be	VBP
cord-280878-1kt51viz	13	8	still	still	RB
cord-280878-1kt51viz	13	9	mostly	mostly	RB
cord-280878-1kt51viz	13	10	in	in	IN
cord-280878-1kt51viz	13	11	their	-PRON-	PRP$
cord-280878-1kt51viz	13	12	infancy	infancy	NN
cord-280878-1kt51viz	13	13	,	,	,
cord-280878-1kt51viz	13	14	and	and	CC
cord-280878-1kt51viz	13	15	together	together	RB
cord-280878-1kt51viz	13	16	with	with	IN
cord-280878-1kt51viz	13	17	those	those	DT
cord-280878-1kt51viz	13	18	for	for	IN
cord-280878-1kt51viz	13	19	AM2	AM2	NNP
cord-280878-1kt51viz	13	20	,	,	,
cord-280878-1kt51viz	13	21	are	be	VBP
cord-280878-1kt51viz	13	22	the	the	DT
cord-280878-1kt51viz	13	23	subject	subject	NN
cord-280878-1kt51viz	13	24	of	of	IN
cord-280878-1kt51viz	13	25	the	the	DT
cord-280878-1kt51viz	13	26	present	present	JJ
cord-280878-1kt51viz	13	27	review	review	NN
cord-280878-1kt51viz	13	28	.	.	.
cord-280878-1kt51viz	14	1	The	the	DT
cord-280878-1kt51viz	14	2	field	field	NN
cord-280878-1kt51viz	14	3	of	of	IN
cord-280878-1kt51viz	14	4	viroporins	viroporin	NNS
cord-280878-1kt51viz	14	5	was	be	VBD
cord-280878-1kt51viz	14	6	born	bear	VBN
cord-280878-1kt51viz	14	7	about	about	IN
cord-280878-1kt51viz	14	8	20	20	CD
cord-280878-1kt51viz	14	9	years	year	NNS
cord-280878-1kt51viz	14	10	ago	ago	RB
cord-280878-1kt51viz	14	11	from	from	IN
cord-280878-1kt51viz	14	12	the	the	DT
cord-280878-1kt51viz	14	13	realization	realization	NN
cord-280878-1kt51viz	14	14	that	that	IN
cord-280878-1kt51viz	14	15	viruses	virus	NNS
cord-280878-1kt51viz	14	16	inflict	inflict	VBP
cord-280878-1kt51viz	14	17	injuries	injury	NNS
cord-280878-1kt51viz	14	18	in	in	IN
cord-280878-1kt51viz	14	19	the	the	DT
cord-280878-1kt51viz	14	20	membranes	membrane	NNS
cord-280878-1kt51viz	14	21	of	of	IN
cord-280878-1kt51viz	14	22	cells	cell	NNS
cord-280878-1kt51viz	14	23	during	during	IN
cord-280878-1kt51viz	14	24	infection	infection	NN
cord-280878-1kt51viz	14	25	,	,	,
cord-280878-1kt51viz	14	26	which	which	WDT
cord-280878-1kt51viz	14	27	results	result	VBZ
cord-280878-1kt51viz	14	28	in	in	IN
cord-280878-1kt51viz	14	29	increased	increase	VBN
cord-280878-1kt51viz	14	30	membrane	membrane	NN
cord-280878-1kt51viz	14	31	permeability	permeability	NN
cord-280878-1kt51viz	14	32	(	(	-LRB-
cord-280878-1kt51viz	14	33	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	14	34	,	,	,
cord-280878-1kt51viz	14	35	1995	1995	CD
cord-280878-1kt51viz	14	36	)	)	-RRB-
cord-280878-1kt51viz	14	37	.	.	.
cord-280878-1kt51viz	15	1	This	this	DT
cord-280878-1kt51viz	15	2	early	early	JJ
cord-280878-1kt51viz	15	3	observation	observation	NN
cord-280878-1kt51viz	15	4	heralded	herald	VBD
cord-280878-1kt51viz	15	5	the	the	DT
cord-280878-1kt51viz	15	6	current	current	JJ
cord-280878-1kt51viz	15	7	interest	interest	NN
cord-280878-1kt51viz	15	8	in	in	IN
cord-280878-1kt51viz	15	9	viroporins	viroporin	NNS
cord-280878-1kt51viz	15	10	,	,	,
cord-280878-1kt51viz	15	11	along	along	IN
cord-280878-1kt51viz	15	12	with	with	IN
cord-280878-1kt51viz	15	13	the	the	DT
cord-280878-1kt51viz	15	14	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	15	15	opportunities	opportunity	NNS
cord-280878-1kt51viz	15	16	afforded	afford	VBN
cord-280878-1kt51viz	15	17	by	by	IN
cord-280878-1kt51viz	15	18	the	the	DT
cord-280878-1kt51viz	15	19	modulation	modulation	NN
cord-280878-1kt51viz	15	20	of	of	IN
cord-280878-1kt51viz	15	21	their	-PRON-	PRP$
cord-280878-1kt51viz	15	22	channel	channel	NN
cord-280878-1kt51viz	15	23	activity	activity	NN
cord-280878-1kt51viz	15	24	using	use	VBG
cord-280878-1kt51viz	15	25	small	small	JJ
cord-280878-1kt51viz	15	26	molecules	molecule	NNS
cord-280878-1kt51viz	15	27	(	(	-LRB-
cord-280878-1kt51viz	15	28	Fischer	Fischer	NNP
cord-280878-1kt51viz	15	29	,	,	,
cord-280878-1kt51viz	15	30	Wang	Wang	NNP
cord-280878-1kt51viz	15	31	,	,	,
cord-280878-1kt51viz	15	32	Schindler	Schindler	NNP
cord-280878-1kt51viz	15	33	,	,	,
cord-280878-1kt51viz	15	34	&	&	CC
cord-280878-1kt51viz	15	35	Chen	Chen	NNP
cord-280878-1kt51viz	15	36	,	,	,
cord-280878-1kt51viz	15	37	2012	2012	CD
cord-280878-1kt51viz	15	38	;	;	:
cord-280878-1kt51viz	15	39	Scott	Scott	NNP
cord-280878-1kt51viz	15	40	&	&	CC
cord-280878-1kt51viz	15	41	Griffin	Griffin	NNP
cord-280878-1kt51viz	15	42	,	,	,
cord-280878-1kt51viz	15	43	2015	2015	CD
cord-280878-1kt51viz	15	44	)	)	-RRB-
cord-280878-1kt51viz	15	45	,	,	,
cord-280878-1kt51viz	15	46	and	and	CC
cord-280878-1kt51viz	15	47	the	the	DT
cord-280878-1kt51viz	15	48	deeper	deep	JJR
cord-280878-1kt51viz	15	49	understanding	understanding	NN
cord-280878-1kt51viz	15	50	of	of	IN
cord-280878-1kt51viz	15	51	the	the	DT
cord-280878-1kt51viz	15	52	roles	role	NNS
cord-280878-1kt51viz	15	53	of	of	IN
cord-280878-1kt51viz	15	54	viroporin	viroporin	NNP
cord-280878-1kt51viz	15	55	ion	ion	NN
cord-280878-1kt51viz	15	56	channel	channel	NN
cord-280878-1kt51viz	15	57	activity	activity	NN
cord-280878-1kt51viz	15	58	on	on	IN
cord-280878-1kt51viz	15	59	viral	viral	JJ
cord-280878-1kt51viz	15	60	replication	replication	NN
cord-280878-1kt51viz	15	61	and	and	CC
cord-280878-1kt51viz	15	62	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	15	63	(	(	-LRB-
cord-280878-1kt51viz	15	64	Nieto	Nieto	NNP
cord-280878-1kt51viz	15	65	-	-	HYPH
cord-280878-1kt51viz	15	66	Torres	Torres	NNP
cord-280878-1kt51viz	15	67	,	,	,
cord-280878-1kt51viz	15	68	Verdia	Verdia	NNP
cord-280878-1kt51viz	15	69	-	-	HYPH
cord-280878-1kt51viz	15	70	Baguena	Baguena	NNP
cord-280878-1kt51viz	15	71	,	,	,
cord-280878-1kt51viz	15	72	Castano	Castano	NNP
cord-280878-1kt51viz	15	73	-	-	HYPH
cord-280878-1kt51viz	15	74	Rodriguez	Rodriguez	NNP
cord-280878-1kt51viz	15	75	,	,	,
cord-280878-1kt51viz	15	76	Aguilella	Aguilella	NNP
cord-280878-1kt51viz	15	77	,	,	,
cord-280878-1kt51viz	15	78	&	&	CC
cord-280878-1kt51viz	15	79	Enjuanes	Enjuanes	NNP
cord-280878-1kt51viz	15	80	,	,	,
cord-280878-1kt51viz	15	81	2015	2015	CD
cord-280878-1kt51viz	15	82	)	)	-RRB-
cord-280878-1kt51viz	15	83	.	.	.
cord-280878-1kt51viz	16	1	This	this	DT
cord-280878-1kt51viz	16	2	interest	interest	NN
cord-280878-1kt51viz	16	3	will	will	MD
cord-280878-1kt51viz	16	4	likely	likely	RB
cord-280878-1kt51viz	16	5	increase	increase	VB
cord-280878-1kt51viz	16	6	with	with	IN
cord-280878-1kt51viz	16	7	the	the	DT
cord-280878-1kt51viz	16	8	discovery	discovery	NN
cord-280878-1kt51viz	16	9	of	of	IN
cord-280878-1kt51viz	16	10	new	new	JJ
cord-280878-1kt51viz	16	11	viroporins	viroporin	NNS
cord-280878-1kt51viz	16	12	along	along	IN
cord-280878-1kt51viz	16	13	with	with	IN
cord-280878-1kt51viz	16	14	their	-PRON-	PRP$
cord-280878-1kt51viz	16	15	ever	ever	RB
cord-280878-1kt51viz	16	16	-	-	HYPH
cord-280878-1kt51viz	16	17	growing	grow	VBG
cord-280878-1kt51viz	16	18	roles	role	NNS
cord-280878-1kt51viz	16	19	in	in	IN
cord-280878-1kt51viz	16	20	the	the	DT
cord-280878-1kt51viz	16	21	virus	virus	NN
cord-280878-1kt51viz	16	22	life	life	NN
cord-280878-1kt51viz	16	23	cycle	cycle	NN
cord-280878-1kt51viz	16	24	.	.	.
cord-280878-1kt51viz	17	1	Indeed	indeed	RB
cord-280878-1kt51viz	17	2	,	,	,
cord-280878-1kt51viz	17	3	the	the	DT
cord-280878-1kt51viz	17	4	number	number	NN
cord-280878-1kt51viz	17	5	of	of	IN
cord-280878-1kt51viz	17	6	medically	medically	RB
cord-280878-1kt51viz	17	7	important	important	JJ
cord-280878-1kt51viz	17	8	viroporins	viroporin	NNS
cord-280878-1kt51viz	17	9	known	know	VBN
cord-280878-1kt51viz	17	10	is	be	VBZ
cord-280878-1kt51viz	17	11	expected	expect	VBN
cord-280878-1kt51viz	17	12	to	to	TO
cord-280878-1kt51viz	17	13	rise	rise	VB
cord-280878-1kt51viz	17	14	as	as	IN
cord-280878-1kt51viz	17	15	new	new	JJ
cord-280878-1kt51viz	17	16	human	human	JJ
cord-280878-1kt51viz	17	17	viruses	virus	NNS
cord-280878-1kt51viz	17	18	continuously	continuously	RB
cord-280878-1kt51viz	17	19	emerge	emerge	VBP
cord-280878-1kt51viz	17	20	from	from	IN
cord-280878-1kt51viz	17	21	animal	animal	NN
cord-280878-1kt51viz	17	22	hosts	host	NNS
cord-280878-1kt51viz	17	23	.	.	.
cord-280878-1kt51viz	18	1	It	-PRON-	PRP
cord-280878-1kt51viz	18	2	is	be	VBZ
cord-280878-1kt51viz	18	3	also	also	RB
cord-280878-1kt51viz	18	4	possible	possible	JJ
cord-280878-1kt51viz	18	5	that	that	IN
cord-280878-1kt51viz	18	6	new	new	JJ
cord-280878-1kt51viz	18	7	viroporins	viroporin	NNS
cord-280878-1kt51viz	18	8	may	may	MD
cord-280878-1kt51viz	18	9	have	have	VB
cord-280878-1kt51viz	18	10	novel	novel	JJ
cord-280878-1kt51viz	18	11	features	feature	NNS
cord-280878-1kt51viz	18	12	and	and	CC
cord-280878-1kt51viz	18	13	structural	structural	JJ
cord-280878-1kt51viz	18	14	motifs	motif	NNS
cord-280878-1kt51viz	18	15	which	which	WDT
cord-280878-1kt51viz	18	16	will	will	MD
cord-280878-1kt51viz	18	17	contribute	contribute	VB
cord-280878-1kt51viz	18	18	in	in	IN
cord-280878-1kt51viz	18	19	updating	update	VBG
cord-280878-1kt51viz	18	20	their	-PRON-	PRP$
cord-280878-1kt51viz	18	21	classifications	classification	NNS
cord-280878-1kt51viz	18	22	in	in	IN
cord-280878-1kt51viz	18	23	terms	term	NNS
cord-280878-1kt51viz	18	24	of	of	IN
cord-280878-1kt51viz	18	25	topology	topology	NN
cord-280878-1kt51viz	18	26	and	and	CC
cord-280878-1kt51viz	18	27	number	number	NN
cord-280878-1kt51viz	18	28	of	of	IN
cord-280878-1kt51viz	18	29	transmembrane	transmembrane	NNP
cord-280878-1kt51viz	18	30	α	α	NN
cord-280878-1kt51viz	18	31	-	-	HYPH
cord-280878-1kt51viz	18	32	helical	helical	JJ
cord-280878-1kt51viz	18	33	domains	domain	NNS
cord-280878-1kt51viz	18	34	(	(	-LRB-
cord-280878-1kt51viz	18	35	Nieva	Nieva	NNP
cord-280878-1kt51viz	18	36	,	,	,
cord-280878-1kt51viz	18	37	Madan	Madan	NNP
cord-280878-1kt51viz	18	38	,	,	,
cord-280878-1kt51viz	18	39	&	&	CC
cord-280878-1kt51viz	18	40	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	18	41	,	,	,
cord-280878-1kt51viz	18	42	2012	2012	CD
cord-280878-1kt51viz	18	43	)	)	-RRB-
cord-280878-1kt51viz	18	44	.	.	.
cord-280878-1kt51viz	19	1	In	in	IN
cord-280878-1kt51viz	19	2	vertebrates	vertebrate	NNS
cord-280878-1kt51viz	19	3	alone	alone	RB
cord-280878-1kt51viz	19	4	,	,	,
cord-280878-1kt51viz	19	5	the	the	DT
cord-280878-1kt51viz	19	6	number	number	NN
cord-280878-1kt51viz	19	7	of	of	IN
cord-280878-1kt51viz	19	8	viruses	virus	NNS
cord-280878-1kt51viz	19	9	was	be	VBD
cord-280878-1kt51viz	19	10	estimated	estimate	VBN
cord-280878-1kt51viz	19	11	to	to	TO
cord-280878-1kt51viz	19	12	be	be	VB
cord-280878-1kt51viz	19	13	around	around	RB
cord-280878-1kt51viz	19	14	one	one	CD
cord-280878-1kt51viz	19	15	million	million	CD
cord-280878-1kt51viz	19	16	(	(	-LRB-
cord-280878-1kt51viz	19	17	Morse	Morse	NNP
cord-280878-1kt51viz	19	18	,	,	,
cord-280878-1kt51viz	19	19	1993	1993	CD
cord-280878-1kt51viz	19	20	)	)	-RRB-
cord-280878-1kt51viz	19	21	.	.	.
cord-280878-1kt51viz	20	1	More	More	JJR
cord-280878-1kt51viz	20	2	recent	recent	JJ
cord-280878-1kt51viz	20	3	estimates	estimate	NNS
cord-280878-1kt51viz	20	4	quantify	quantify	VBP
cord-280878-1kt51viz	20	5	the	the	DT
cord-280878-1kt51viz	20	6	viral	viral	JJ
cord-280878-1kt51viz	20	7	diversity	diversity	NN
cord-280878-1kt51viz	20	8	in	in	IN
cord-280878-1kt51viz	20	9	mammals	mammal	NNS
cord-280878-1kt51viz	20	10	,	,	,
cord-280878-1kt51viz	20	11	which	which	WDT
cord-280878-1kt51viz	20	12	are	be	VBP
cord-280878-1kt51viz	20	13	the	the	DT
cord-280878-1kt51viz	20	14	reservoir	reservoir	NN
cord-280878-1kt51viz	20	15	hosts	host	NNS
cord-280878-1kt51viz	20	16	of	of	IN
cord-280878-1kt51viz	20	17	the	the	DT
cord-280878-1kt51viz	20	18	majority	majority	NN
cord-280878-1kt51viz	20	19	of	of	IN
cord-280878-1kt51viz	20	20	emerging	emerge	VBG
cord-280878-1kt51viz	20	21	zoonoses	zoonosis	NNS
cord-280878-1kt51viz	20	22	,	,	,
cord-280878-1kt51viz	20	23	as	as	IN
cord-280878-1kt51viz	20	24	320,000	320,000	CD
cord-280878-1kt51viz	20	25	(	(	-LRB-
cord-280878-1kt51viz	20	26	Anthony	Anthony	NNP
cord-280878-1kt51viz	20	27	et	et	NNP
cord-280878-1kt51viz	20	28	al	al	NNP
cord-280878-1kt51viz	20	29	.	.	NNP
cord-280878-1kt51viz	20	30	,	,	,
cord-280878-1kt51viz	20	31	2013	2013	CD
cord-280878-1kt51viz	20	32	)	)	-RRB-
cord-280878-1kt51viz	20	33	.	.	.
cord-280878-1kt51viz	21	1	This	this	DT
cord-280878-1kt51viz	21	2	strongly	strongly	RB
cord-280878-1kt51viz	21	3	contrasts	contrast	VBZ
cord-280878-1kt51viz	21	4	with	with	IN
cord-280878-1kt51viz	21	5	the	the	DT
cord-280878-1kt51viz	21	6	few	few	JJ
cord-280878-1kt51viz	21	7	thousand	thousand	CD
cord-280878-1kt51viz	21	8	viruses	virus	NNS
cord-280878-1kt51viz	21	9	identified	identify	VBN
cord-280878-1kt51viz	21	10	to	to	IN
cord-280878-1kt51viz	21	11	date	date	NN
cord-280878-1kt51viz	21	12	,	,	,
cord-280878-1kt51viz	21	13	which	which	WDT
cord-280878-1kt51viz	21	14	means	mean	VBZ
cord-280878-1kt51viz	21	15	that	that	IN
cord-280878-1kt51viz	21	16	more	more	JJR
cord-280878-1kt51viz	21	17	than	than	IN
cord-280878-1kt51viz	21	18	99	99	CD
cord-280878-1kt51viz	21	19	%	%	NN
cord-280878-1kt51viz	21	20	of	of	IN
cord-280878-1kt51viz	21	21	viruses	virus	NNS
cord-280878-1kt51viz	21	22	-	-	:
cord-280878-1kt51viz	21	23	and	and	CC
cord-280878-1kt51viz	21	24	their	-PRON-	PRP$
cord-280878-1kt51viz	21	25	viroporins	viroporin	NNS
cord-280878-1kt51viz	21	26	,	,	,
cord-280878-1kt51viz	21	27	if	if	IN
cord-280878-1kt51viz	21	28	any	any	DT
cord-280878-1kt51viz	21	29	-	-	:
cord-280878-1kt51viz	21	30	are	be	VBP
cord-280878-1kt51viz	21	31	still	still	RB
cord-280878-1kt51viz	21	32	unknown	unknown	JJ
cord-280878-1kt51viz	21	33	.	.	.
cord-280878-1kt51viz	22	1	Most	Most	JJS
cord-280878-1kt51viz	22	2	viroporins	viroporin	NNS
cord-280878-1kt51viz	22	3	have	have	VBP
cord-280878-1kt51viz	22	4	been	be	VBN
cord-280878-1kt51viz	22	5	identified	identify	VBN
cord-280878-1kt51viz	22	6	as	as	IN
cord-280878-1kt51viz	22	7	virulence	virulence	NN
cord-280878-1kt51viz	22	8	factors	factor	NNS
cord-280878-1kt51viz	22	9	that	that	WDT
cord-280878-1kt51viz	22	10	lead	lead	VBP
cord-280878-1kt51viz	22	11	to	to	IN
cord-280878-1kt51viz	22	12	viral	viral	JJ
cord-280878-1kt51viz	22	13	attenuation	attenuation	NN
cord-280878-1kt51viz	22	14	when	when	WRB
cord-280878-1kt51viz	22	15	deleted	delete	VBN
cord-280878-1kt51viz	22	16	.	.	.
cord-280878-1kt51viz	23	1	This	this	DT
cord-280878-1kt51viz	23	2	attenuation	attenuation	NN
cord-280878-1kt51viz	23	3	is	be	VBZ
cord-280878-1kt51viz	23	4	attributed	attribute	VBN
cord-280878-1kt51viz	23	5	only	only	RB
cord-280878-1kt51viz	23	6	in	in	IN
cord-280878-1kt51viz	23	7	part	part	NN
cord-280878-1kt51viz	23	8	to	to	IN
cord-280878-1kt51viz	23	9	their	-PRON-	PRP$
cord-280878-1kt51viz	23	10	channel	channel	NN
cord-280878-1kt51viz	23	11	activity	activity	NN
cord-280878-1kt51viz	23	12	,	,	,
cord-280878-1kt51viz	23	13	but	but	CC
cord-280878-1kt51viz	23	14	nevertheless	nevertheless	RB
cord-280878-1kt51viz	23	15	small	small	JJ
cord-280878-1kt51viz	23	16	-	-	HYPH
cord-280878-1kt51viz	23	17	molecule	molecule	NN
cord-280878-1kt51viz	23	18	channel	channel	NN
cord-280878-1kt51viz	23	19	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	23	20	have	have	VBP
cord-280878-1kt51viz	23	21	been	be	VBN
cord-280878-1kt51viz	23	22	sought	seek	VBN
cord-280878-1kt51viz	23	23	after	after	IN
cord-280878-1kt51viz	23	24	.	.	.
cord-280878-1kt51viz	24	1	The	the	DT
cord-280878-1kt51viz	24	2	vast	vast	JJ
cord-280878-1kt51viz	24	3	majority	majority	NN
cord-280878-1kt51viz	24	4	of	of	IN
cord-280878-1kt51viz	24	5	these	these	DT
cord-280878-1kt51viz	24	6	channel	channel	NN
cord-280878-1kt51viz	24	7	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	24	8	have	have	VBP
cord-280878-1kt51viz	24	9	been	be	VBN
cord-280878-1kt51viz	24	10	developed	develop	VBN
cord-280878-1kt51viz	24	11	against	against	IN
cord-280878-1kt51viz	24	12	the	the	DT
cord-280878-1kt51viz	24	13	influenza	influenza	NN
cord-280878-1kt51viz	24	14	A	a	DT
cord-280878-1kt51viz	24	15	virus	virus	NN
cord-280878-1kt51viz	24	16	M2	m2	NN
cord-280878-1kt51viz	24	17	(	(	-LRB-
cord-280878-1kt51viz	24	18	IAV	IAV	NNP
cord-280878-1kt51viz	24	19	M2	M2	NNP
cord-280878-1kt51viz	24	20	or	or	CC
cord-280878-1kt51viz	24	21	AM2	AM2	NNP
cord-280878-1kt51viz	24	22	)	)	-RRB-
cord-280878-1kt51viz	24	23	protein	protein	NN
cord-280878-1kt51viz	24	24	(	(	-LRB-
cord-280878-1kt51viz	24	25	reviewed	review	VBN
cord-280878-1kt51viz	24	26	recently	recently	RB
cord-280878-1kt51viz	24	27	in	in	IN
cord-280878-1kt51viz	24	28	Du	Du	NNP
cord-280878-1kt51viz	24	29	,	,	,
cord-280878-1kt51viz	24	30	Cross	Cross	NNP
cord-280878-1kt51viz	24	31	,	,	,
cord-280878-1kt51viz	24	32	&	&	CC
cord-280878-1kt51viz	24	33	Zhou	Zhou	NNP
cord-280878-1kt51viz	24	34	,	,	,
cord-280878-1kt51viz	24	35	2012	2012	CD
cord-280878-1kt51viz	24	36	;	;	:
cord-280878-1kt51viz	24	37	Gu	Gu	NNP
cord-280878-1kt51viz	24	38	,	,	,
cord-280878-1kt51viz	24	39	Liu	Liu	NNP
cord-280878-1kt51viz	24	40	,	,	,
cord-280878-1kt51viz	24	41	&	&	CC
cord-280878-1kt51viz	24	42	Wei	Wei	NNP
cord-280878-1kt51viz	24	43	,	,	,
cord-280878-1kt51viz	24	44	2013	2013	CD
cord-280878-1kt51viz	24	45	)	)	-RRB-
cord-280878-1kt51viz	24	46	,	,	,
cord-280878-1kt51viz	24	47	which	which	WDT
cord-280878-1kt51viz	24	48	is	be	VBZ
cord-280878-1kt51viz	24	49	the	the	DT
cord-280878-1kt51viz	24	50	first	first	JJ
cord-280878-1kt51viz	24	51	viroporin	viroporin	NN
cord-280878-1kt51viz	24	52	discovered	discover	VBN
cord-280878-1kt51viz	24	53	.	.	.
cord-280878-1kt51viz	25	1	This	this	DT
cord-280878-1kt51viz	25	2	is	be	VBZ
cord-280878-1kt51viz	25	3	not	not	RB
cord-280878-1kt51viz	25	4	surprising	surprising	JJ
cord-280878-1kt51viz	25	5	since	since	IN
cord-280878-1kt51viz	25	6	AM2	AM2	NNP
cord-280878-1kt51viz	25	7	is	be	VBZ
cord-280878-1kt51viz	25	8	the	the	DT
cord-280878-1kt51viz	25	9	best	well	RBS
cord-280878-1kt51viz	25	10	characterized	characterize	VBN
cord-280878-1kt51viz	25	11	viroporin	viroporin	NN
cord-280878-1kt51viz	25	12	to	to	IN
cord-280878-1kt51viz	25	13	date	date	NN
cord-280878-1kt51viz	25	14	,	,	,
cord-280878-1kt51viz	25	15	with	with	IN
cord-280878-1kt51viz	25	16	a	a	DT
cord-280878-1kt51viz	25	17	well	well	RB
cord-280878-1kt51viz	25	18	-	-	HYPH
cord-280878-1kt51viz	25	19	established	establish	VBN
cord-280878-1kt51viz	25	20	biological	biological	JJ
cord-280878-1kt51viz	25	21	role	role	NN
cord-280878-1kt51viz	25	22	in	in	IN
cord-280878-1kt51viz	25	23	viral	viral	JJ
cord-280878-1kt51viz	25	24	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	25	25	combined	combine	VBN
cord-280878-1kt51viz	25	26	the	the	DT
cord-280878-1kt51viz	25	27	most	most	RBS
cord-280878-1kt51viz	25	28	extensive	extensive	JJ
cord-280878-1kt51viz	25	29	structural	structural	JJ
cord-280878-1kt51viz	25	30	investigations	investigation	NNS
cord-280878-1kt51viz	25	31	conducted	conduct	VBN
cord-280878-1kt51viz	25	32	,	,	,
cord-280878-1kt51viz	25	33	and	and	CC
cord-280878-1kt51viz	25	34	has	have	VBZ
cord-280878-1kt51viz	25	35	emerged	emerge	VBN
cord-280878-1kt51viz	25	36	as	as	IN
cord-280878-1kt51viz	25	37	a	a	DT
cord-280878-1kt51viz	25	38	validated	validate	VBN
cord-280878-1kt51viz	25	39	drug	drug	NN
cord-280878-1kt51viz	25	40	target	target	NN
cord-280878-1kt51viz	25	41	.	.	.
cord-280878-1kt51viz	26	1	For	for	IN
cord-280878-1kt51viz	26	2	other	other	JJ
cord-280878-1kt51viz	26	3	viroporins	viroporin	NNS
cord-280878-1kt51viz	26	4	,	,	,
cord-280878-1kt51viz	26	5	these	these	DT
cord-280878-1kt51viz	26	6	studies	study	NNS
cord-280878-1kt51viz	26	7	are	be	VBP
cord-280878-1kt51viz	26	8	still	still	RB
cord-280878-1kt51viz	26	9	mostly	mostly	RB
cord-280878-1kt51viz	26	10	in	in	IN
cord-280878-1kt51viz	26	11	their	-PRON-	PRP$
cord-280878-1kt51viz	26	12	infancy	infancy	NN
cord-280878-1kt51viz	26	13	,	,	,
cord-280878-1kt51viz	26	14	although	although	IN
cord-280878-1kt51viz	26	15	a	a	DT
cord-280878-1kt51viz	26	16	highresolution	highresolution	NN
cord-280878-1kt51viz	26	17	structure	structure	NN
cord-280878-1kt51viz	26	18	of	of	IN
cord-280878-1kt51viz	26	19	the	the	DT
cord-280878-1kt51viz	26	20	hepatitis	hepatitis	NN
cord-280878-1kt51viz	26	21	C	C	NNP
cord-280878-1kt51viz	26	22	virus	virus	NN
cord-280878-1kt51viz	26	23	(	(	-LRB-
cord-280878-1kt51viz	26	24	HCV	HCV	NNP
cord-280878-1kt51viz	26	25	)	)	-RRB-
cord-280878-1kt51viz	26	26	p7	p7	NN
cord-280878-1kt51viz	26	27	protein	protein	NN
cord-280878-1kt51viz	26	28	has	have	VBZ
cord-280878-1kt51viz	26	29	been	be	VBN
cord-280878-1kt51viz	26	30	recently	recently	RB
cord-280878-1kt51viz	26	31	described	describe	VBN
cord-280878-1kt51viz	27	1	(	(	-LRB-
cord-280878-1kt51viz	27	2	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	27	3	et	et	NNP
cord-280878-1kt51viz	27	4	al	al	NNP
cord-280878-1kt51viz	27	5	.	.	NNP
cord-280878-1kt51viz	27	6	,	,	,
cord-280878-1kt51viz	27	7	2013	2013	CD
cord-280878-1kt51viz	27	8	)	)	-RRB-
cord-280878-1kt51viz	27	9	that	that	WDT
cord-280878-1kt51viz	27	10	may	may	MD
cord-280878-1kt51viz	27	11	be	be	VB
cord-280878-1kt51viz	27	12	useful	useful	JJ
cord-280878-1kt51viz	27	13	for	for	IN
cord-280878-1kt51viz	27	14	the	the	DT
cord-280878-1kt51viz	27	15	rational	rational	JJ
cord-280878-1kt51viz	27	16	design	design	NN
cord-280878-1kt51viz	27	17	of	of	IN
cord-280878-1kt51viz	27	18	p7	p7	NN
cord-280878-1kt51viz	27	19	channel	channel	NN
cord-280878-1kt51viz	27	20	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	27	21	in	in	IN
cord-280878-1kt51viz	27	22	the	the	DT
cord-280878-1kt51viz	27	23	future	future	NN
cord-280878-1kt51viz	27	24	.	.	.
cord-280878-1kt51viz	28	1	However	however	RB
cord-280878-1kt51viz	28	2	,	,	,
cord-280878-1kt51viz	28	3	attempts	attempt	VBZ
cord-280878-1kt51viz	28	4	to	to	TO
cord-280878-1kt51viz	28	5	rationally	rationally	RB
cord-280878-1kt51viz	28	6	design	design	VB
cord-280878-1kt51viz	28	7	small	small	JJ
cord-280878-1kt51viz	28	8	-	-	HYPH
cord-280878-1kt51viz	28	9	molecule	molecule	NN
cord-280878-1kt51viz	28	10	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	28	11	against	against	IN
cord-280878-1kt51viz	28	12	viroporins	viroporin	NNS
cord-280878-1kt51viz	28	13	will	will	MD
cord-280878-1kt51viz	28	14	encounter	encounter	VB
cord-280878-1kt51viz	28	15	several	several	JJ
cord-280878-1kt51viz	28	16	challenges	challenge	NNS
cord-280878-1kt51viz	28	17	.	.	.
cord-280878-1kt51viz	29	1	One	one	CD
cord-280878-1kt51viz	29	2	is	be	VBZ
cord-280878-1kt51viz	29	3	the	the	DT
cord-280878-1kt51viz	29	4	potential	potential	NN
cord-280878-1kt51viz	29	5	for	for	IN
cord-280878-1kt51viz	29	6	sequence	sequence	NN
cord-280878-1kt51viz	29	7	variability	variability	NN
cord-280878-1kt51viz	29	8	in	in	IN
cord-280878-1kt51viz	29	9	the	the	DT
cord-280878-1kt51viz	29	10	viroporin	viroporin	NN
cord-280878-1kt51viz	29	11	.	.	.
cord-280878-1kt51viz	30	1	Indeed	indeed	RB
cord-280878-1kt51viz	30	2	,	,	,
cord-280878-1kt51viz	30	3	it	-PRON-	PRP
cord-280878-1kt51viz	30	4	has	have	VBZ
cord-280878-1kt51viz	30	5	been	be	VBN
cord-280878-1kt51viz	30	6	argued	argue	VBN
cord-280878-1kt51viz	30	7	that	that	IN
cord-280878-1kt51viz	30	8	since	since	IN
cord-280878-1kt51viz	30	9	the	the	DT
cord-280878-1kt51viz	30	10	number	number	NN
cord-280878-1kt51viz	30	11	of	of	IN
cord-280878-1kt51viz	30	12	genes	gene	NNS
cord-280878-1kt51viz	30	13	susceptible	susceptible	JJ
cord-280878-1kt51viz	30	14	to	to	IN
cord-280878-1kt51viz	30	15	deleterious	deleterious	JJ
cord-280878-1kt51viz	30	16	mutations	mutation	NNS
cord-280878-1kt51viz	30	17	increase	increase	VBP
cord-280878-1kt51viz	30	18	with	with	IN
cord-280878-1kt51viz	30	19	genome	genome	NN
cord-280878-1kt51viz	30	20	size	size	NN
cord-280878-1kt51viz	30	21	,	,	,
cord-280878-1kt51viz	30	22	mutation	mutation	NN
cord-280878-1kt51viz	30	23	rates	rate	NNS
cord-280878-1kt51viz	30	24	are	be	VBP
cord-280878-1kt51viz	30	25	higher	high	JJR
cord-280878-1kt51viz	30	26	for	for	IN
cord-280878-1kt51viz	30	27	small	small	JJ
cord-280878-1kt51viz	30	28	genomes	genome	NNS
cord-280878-1kt51viz	30	29	(	(	-LRB-
cord-280878-1kt51viz	30	30	Drake	Drake	NNP
cord-280878-1kt51viz	30	31	,	,	,
cord-280878-1kt51viz	30	32	1969	1969	CD
cord-280878-1kt51viz	30	33	)	)	-RRB-
cord-280878-1kt51viz	30	34	.	.	.
cord-280878-1kt51viz	31	1	A	a	DT
cord-280878-1kt51viz	31	2	related	related	JJ
cord-280878-1kt51viz	31	3	problem	problem	NN
cord-280878-1kt51viz	31	4	is	be	VBZ
cord-280878-1kt51viz	31	5	that	that	IN
cord-280878-1kt51viz	31	6	viral	viral	JJ
cord-280878-1kt51viz	31	7	proteins	protein	NNS
cord-280878-1kt51viz	31	8	,	,	,
cord-280878-1kt51viz	31	9	when	when	WRB
cord-280878-1kt51viz	31	10	compared	compare	VBN
cord-280878-1kt51viz	31	11	to	to	IN
cord-280878-1kt51viz	31	12	prokaryotic	prokaryotic	JJ
cord-280878-1kt51viz	31	13	and	and	CC
cord-280878-1kt51viz	31	14	eukaryotic	eukaryotic	JJ
cord-280878-1kt51viz	31	15	proteins	protein	NNS
cord-280878-1kt51viz	31	16	,	,	,
cord-280878-1kt51viz	31	17	have	have	VBP
cord-280878-1kt51viz	31	18	a	a	DT
cord-280878-1kt51viz	31	19	higher	high	JJR
cord-280878-1kt51viz	31	20	degree	degree	NN
cord-280878-1kt51viz	31	21	of	of	IN
cord-280878-1kt51viz	31	22	structural	structural	JJ
cord-280878-1kt51viz	31	23	flexibility	flexibility	NN
cord-280878-1kt51viz	31	24	that	that	WDT
cord-280878-1kt51viz	31	25	may	may	MD
cord-280878-1kt51viz	31	26	represent	represent	VB
cord-280878-1kt51viz	31	27	adaptation	adaptation	NN
cord-280878-1kt51viz	31	28	mechanisms	mechanism	NNS
cord-280878-1kt51viz	31	29	to	to	TO
cord-280878-1kt51viz	31	30	increase	increase	VB
cord-280878-1kt51viz	31	31	resistance	resistance	NN
cord-280878-1kt51viz	31	32	to	to	IN
cord-280878-1kt51viz	31	33	random	random	JJ
cord-280878-1kt51viz	31	34	mutations	mutation	NNS
cord-280878-1kt51viz	31	35	,	,	,
cord-280878-1kt51viz	31	36	especially	especially	RB
cord-280878-1kt51viz	31	37	in	in	IN
cord-280878-1kt51viz	31	38	the	the	DT
cord-280878-1kt51viz	31	39	case	case	NN
cord-280878-1kt51viz	31	40	of	of	IN
cord-280878-1kt51viz	31	41	RNA	RNA	NNP
cord-280878-1kt51viz	31	42	viruses	virus	NNS
cord-280878-1kt51viz	31	43	,	,	,
cord-280878-1kt51viz	31	44	which	which	WDT
cord-280878-1kt51viz	31	45	mutate	mutate	VBP
cord-280878-1kt51viz	31	46	and	and	CC
cord-280878-1kt51viz	31	47	evolve	evolve	VBP
cord-280878-1kt51viz	31	48	faster	fast	JJR
cord-280878-1kt51viz	31	49	than	than	IN
cord-280878-1kt51viz	31	50	DNA	dna	NN
cord-280878-1kt51viz	31	51	viruses	virus	NNS
cord-280878-1kt51viz	31	52	.	.	.
cord-280878-1kt51viz	32	1	A	a	DT
cord-280878-1kt51viz	32	2	less	less	RBR
cord-280878-1kt51viz	32	3	dense	dense	JJ
cord-280878-1kt51viz	32	4	packing	packing	NN
cord-280878-1kt51viz	32	5	,	,	,
cord-280878-1kt51viz	32	6	and	and	CC
cord-280878-1kt51viz	32	7	a	a	DT
cord-280878-1kt51viz	32	8	concomitant	concomitant	JJ
cord-280878-1kt51viz	32	9	smaller	small	JJR
cord-280878-1kt51viz	32	10	number	number	NN
cord-280878-1kt51viz	32	11	of	of	IN
cord-280878-1kt51viz	32	12	network	network	NN
cord-280878-1kt51viz	32	13	interactions	interaction	NNS
cord-280878-1kt51viz	32	14	,	,	,
cord-280878-1kt51viz	32	15	translates	translate	VBZ
cord-280878-1kt51viz	32	16	not	not	RB
cord-280878-1kt51viz	32	17	only	only	RB
cord-280878-1kt51viz	32	18	to	to	IN
cord-280878-1kt51viz	32	19	a	a	DT
cord-280878-1kt51viz	32	20	smaller	small	JJR
cord-280878-1kt51viz	32	21	difference	difference	NN
cord-280878-1kt51viz	32	22	in	in	IN
cord-280878-1kt51viz	32	23	energy	energy	NN
cord-280878-1kt51viz	32	24	between	between	IN
cord-280878-1kt51viz	32	25	folded	fold	VBN
cord-280878-1kt51viz	32	26	and	and	CC
cord-280878-1kt51viz	32	27	unfolded	unfold	VBN
cord-280878-1kt51viz	32	28	states	state	NNS
cord-280878-1kt51viz	32	29	,	,	,
cord-280878-1kt51viz	32	30	but	but	CC
cord-280878-1kt51viz	32	31	an	an	DT
cord-280878-1kt51viz	32	32	also	also	RB
cord-280878-1kt51viz	32	33	smaller	small	JJR
cord-280878-1kt51viz	32	34	percentual	percentual	JJ
cord-280878-1kt51viz	32	35	contribution	contribution	NN
cord-280878-1kt51viz	32	36	of	of	IN
cord-280878-1kt51viz	32	37	each	each	DT
cord-280878-1kt51viz	32	38	mutation	mutation	NN
cord-280878-1kt51viz	32	39	to	to	IN
cord-280878-1kt51viz	32	40	stability	stability	NN
cord-280878-1kt51viz	32	41	(	(	-LRB-
cord-280878-1kt51viz	32	42	Tokuriki	Tokuriki	NNP
cord-280878-1kt51viz	32	43	,	,	,
cord-280878-1kt51viz	32	44	Oldfield	Oldfield	NNP
cord-280878-1kt51viz	32	45	,	,	,
cord-280878-1kt51viz	32	46	Uversky	Uversky	NNP
cord-280878-1kt51viz	32	47	,	,	,
cord-280878-1kt51viz	32	48	Berezovsky	Berezovsky	NNP
cord-280878-1kt51viz	32	49	,	,	,
cord-280878-1kt51viz	32	50	&	&	CC
cord-280878-1kt51viz	32	51	Tawfik	Tawfik	NNP
cord-280878-1kt51viz	32	52	,	,	,
cord-280878-1kt51viz	32	53	2009	2009	CD
cord-280878-1kt51viz	32	54	)	)	-RRB-
cord-280878-1kt51viz	32	55	.	.	.
cord-280878-1kt51viz	33	1	Additionally	additionally	RB
cord-280878-1kt51viz	33	2	,	,	,
cord-280878-1kt51viz	33	3	this	this	DT
cord-280878-1kt51viz	33	4	enhanced	enhanced	JJ
cord-280878-1kt51viz	33	5	flexibility	flexibility	NN
cord-280878-1kt51viz	33	6	may	may	MD
cord-280878-1kt51viz	33	7	have	have	VB
cord-280878-1kt51viz	33	8	an	an	DT
cord-280878-1kt51viz	33	9	impact	impact	NN
cord-280878-1kt51viz	33	10	on	on	IN
cord-280878-1kt51viz	33	11	the	the	DT
cord-280878-1kt51viz	33	12	ability	ability	NN
cord-280878-1kt51viz	33	13	of	of	IN
cord-280878-1kt51viz	33	14	a	a	DT
cord-280878-1kt51viz	33	15	single	single	JJ
cord-280878-1kt51viz	33	16	protein	protein	NN
cord-280878-1kt51viz	33	17	to	to	TO
cord-280878-1kt51viz	33	18	perform	perform	VB
cord-280878-1kt51viz	33	19	a	a	DT
cord-280878-1kt51viz	33	20	variety	variety	NN
cord-280878-1kt51viz	33	21	of	of	IN
cord-280878-1kt51viz	33	22	tasks	task	NNS
cord-280878-1kt51viz	33	23	,	,	,
cord-280878-1kt51viz	33	24	consistent	consistent	JJ
cord-280878-1kt51viz	33	25	with	with	IN
cord-280878-1kt51viz	33	26	the	the	DT
cord-280878-1kt51viz	33	27	economical	economical	JJ
cord-280878-1kt51viz	33	28	use	use	NN
cord-280878-1kt51viz	33	29	of	of	IN
cord-280878-1kt51viz	33	30	resources	resource	NNS
cord-280878-1kt51viz	33	31	in	in	IN
cord-280878-1kt51viz	33	32	viruses	virus	NNS
cord-280878-1kt51viz	33	33	.	.	.
cord-280878-1kt51viz	34	1	Adding	add	VBG
cord-280878-1kt51viz	34	2	to	to	IN
cord-280878-1kt51viz	34	3	this	this	DT
cord-280878-1kt51viz	34	4	intrinsic	intrinsic	JJ
cord-280878-1kt51viz	34	5	flexibility	flexibility	NN
cord-280878-1kt51viz	34	6	,	,	,
cord-280878-1kt51viz	34	7	another	another	DT
cord-280878-1kt51viz	34	8	problem	problem	NN
cord-280878-1kt51viz	34	9	in	in	IN
cord-280878-1kt51viz	34	10	structure	structure	NN
cord-280878-1kt51viz	34	11	-	-	HYPH
cord-280878-1kt51viz	34	12	based	base	VBN
cord-280878-1kt51viz	34	13	drug	drug	NN
cord-280878-1kt51viz	34	14	discovery	discovery	NN
cord-280878-1kt51viz	34	15	concerning	concern	VBG
cord-280878-1kt51viz	34	16	viroporins	viroporin	NNS
cord-280878-1kt51viz	34	17	is	be	VBZ
cord-280878-1kt51viz	34	18	the	the	DT
cord-280878-1kt51viz	34	19	strong	strong	JJ
cord-280878-1kt51viz	34	20	dependence	dependence	NN
cord-280878-1kt51viz	34	21	of	of	IN
cord-280878-1kt51viz	34	22	the	the	DT
cord-280878-1kt51viz	34	23	protein	protein	NN
cord-280878-1kt51viz	34	24	structure	structure	NN
cord-280878-1kt51viz	34	25	on	on	IN
cord-280878-1kt51viz	34	26	environment	environment	NN
cord-280878-1kt51viz	34	27	.	.	.
cord-280878-1kt51viz	35	1	Indeed	indeed	RB
cord-280878-1kt51viz	35	2	,	,	,
cord-280878-1kt51viz	35	3	solution	solution	NN
cord-280878-1kt51viz	35	4	NMR	nmr	NN
cord-280878-1kt51viz	35	5	can	can	MD
cord-280878-1kt51viz	35	6	be	be	VB
cord-280878-1kt51viz	35	7	applied	apply	VBN
cord-280878-1kt51viz	35	8	to	to	TO
cord-280878-1kt51viz	35	9	study	study	VB
cord-280878-1kt51viz	35	10	small	small	JJ
cord-280878-1kt51viz	35	11	-	-	HYPH
cord-280878-1kt51viz	35	12	membrane	membrane	NN
cord-280878-1kt51viz	35	13	proteins	protein	NNS
cord-280878-1kt51viz	35	14	in	in	IN
cord-280878-1kt51viz	35	15	membrane	membrane	NN
cord-280878-1kt51viz	35	16	-	-	HYPH
cord-280878-1kt51viz	35	17	mimicking	mimic	VBG
cord-280878-1kt51viz	35	18	environments	environment	NNS
cord-280878-1kt51viz	35	19	that	that	WDT
cord-280878-1kt51viz	35	20	allow	allow	VBP
cord-280878-1kt51viz	35	21	rapid	rapid	JJ
cord-280878-1kt51viz	35	22	reorientation	reorientation	NN
cord-280878-1kt51viz	35	23	,	,	,
cord-280878-1kt51viz	35	24	but	but	CC
cord-280878-1kt51viz	35	25	these	these	DT
cord-280878-1kt51viz	35	26	artificial	artificial	JJ
cord-280878-1kt51viz	35	27	systems	system	NNS
cord-280878-1kt51viz	35	28	may	may	MD
cord-280878-1kt51viz	35	29	also	also	RB
cord-280878-1kt51viz	35	30	alter	alter	VB
cord-280878-1kt51viz	35	31	the	the	DT
cord-280878-1kt51viz	35	32	intrinsic	intrinsic	JJ
cord-280878-1kt51viz	35	33	properties	property	NNS
cord-280878-1kt51viz	35	34	of	of	IN
cord-280878-1kt51viz	35	35	the	the	DT
cord-280878-1kt51viz	35	36	proteins	protein	NNS
cord-280878-1kt51viz	35	37	(	(	-LRB-
cord-280878-1kt51viz	35	38	Cross	Cross	NNP
cord-280878-1kt51viz	35	39	,	,	,
cord-280878-1kt51viz	35	40	Dong	Dong	NNP
cord-280878-1kt51viz	35	41	,	,	,
cord-280878-1kt51viz	35	42	Sharma	Sharma	NNP
cord-280878-1kt51viz	35	43	,	,	,
cord-280878-1kt51viz	35	44	Busath	Busath	NNP
cord-280878-1kt51viz	35	45	,	,	,
cord-280878-1kt51viz	35	46	&	&	CC
cord-280878-1kt51viz	35	47	Zhou	Zhou	NNP
cord-280878-1kt51viz	35	48	,	,	,
cord-280878-1kt51viz	35	49	2012	2012	CD
cord-280878-1kt51viz	35	50	;	;	:
cord-280878-1kt51viz	35	51	Cross	Cross	NNP
cord-280878-1kt51viz	35	52	,	,	,
cord-280878-1kt51viz	35	53	Sharma	Sharma	NNP
cord-280878-1kt51viz	35	54	,	,	,
cord-280878-1kt51viz	35	55	Yi	Yi	NNP
cord-280878-1kt51viz	35	56	,	,	,
cord-280878-1kt51viz	35	57	&	&	CC
cord-280878-1kt51viz	35	58	Zhou	Zhou	NNP
cord-280878-1kt51viz	35	59	,	,	,
cord-280878-1kt51viz	35	60	2011	2011	CD
cord-280878-1kt51viz	35	61	)	)	-RRB-
cord-280878-1kt51viz	35	62	.	.	.
cord-280878-1kt51viz	36	1	Last	last	RB
cord-280878-1kt51viz	36	2	,	,	,
cord-280878-1kt51viz	36	3	some	some	DT
cord-280878-1kt51viz	36	4	viroporins	viroporin	NNS
cord-280878-1kt51viz	36	5	seem	seem	VBP
cord-280878-1kt51viz	36	6	to	to	TO
cord-280878-1kt51viz	36	7	form	form	VB
cord-280878-1kt51viz	36	8	a	a	DT
cord-280878-1kt51viz	36	9	protein	protein	NN
cord-280878-1kt51viz	36	10	-	-	HYPH
cord-280878-1kt51viz	36	11	lipid	lipid	NN
cord-280878-1kt51viz	36	12	complex	complex	NN
cord-280878-1kt51viz	36	13	rather	rather	RB
cord-280878-1kt51viz	36	14	than	than	IN
cord-280878-1kt51viz	36	15	a	a	DT
cord-280878-1kt51viz	36	16	purely	purely	RB
cord-280878-1kt51viz	36	17	proteinaceous	proteinaceous	JJ
cord-280878-1kt51viz	36	18	pore	pore	NN
cord-280878-1kt51viz	36	19	,	,	,
cord-280878-1kt51viz	36	20	as	as	IN
cord-280878-1kt51viz	36	21	shown	show	VBN
cord-280878-1kt51viz	36	22	for	for	IN
cord-280878-1kt51viz	36	23	the	the	DT
cord-280878-1kt51viz	36	24	VP4	vp4	JJ
cord-280878-1kt51viz	36	25	protein	protein	NN
cord-280878-1kt51viz	36	26	in	in	IN
cord-280878-1kt51viz	36	27	the	the	DT
cord-280878-1kt51viz	36	28	triatoma	triatoma	NNP
cord-280878-1kt51viz	36	29	virus	virus	NN
cord-280878-1kt51viz	37	1	(	(	-LRB-
cord-280878-1kt51viz	37	2	Sanchez	Sanchez	NNP
cord-280878-1kt51viz	37	3	-	-	HYPH
cord-280878-1kt51viz	37	4	Eugenia	Eugenia	NNP
cord-280878-1kt51viz	37	5	,	,	,
cord-280878-1kt51viz	37	6	Goikolea	Goikolea	NNP
cord-280878-1kt51viz	37	7	,	,	,
cord-280878-1kt51viz	37	8	Gil	Gil	NNP
cord-280878-1kt51viz	37	9	-	-	HYPH
cord-280878-1kt51viz	37	10	Carton	Carton	NNP
cord-280878-1kt51viz	37	11	,	,	,
cord-280878-1kt51viz	37	12	Sanchez	Sanchez	NNP
cord-280878-1kt51viz	37	13	-	-	HYPH
cord-280878-1kt51viz	37	14	Magraner	Magraner	NNP
cord-280878-1kt51viz	37	15	,	,	,
cord-280878-1kt51viz	37	16	&	&	CC
cord-280878-1kt51viz	37	17	Guerin	Guerin	NNP
cord-280878-1kt51viz	37	18	,	,	,
cord-280878-1kt51viz	37	19	2015	2015	CD
cord-280878-1kt51viz	37	20	)	)	-RRB-
cord-280878-1kt51viz	37	21	,	,	,
cord-280878-1kt51viz	37	22	and	and	CC
cord-280878-1kt51viz	37	23	similar	similar	JJ
cord-280878-1kt51viz	37	24	observations	observation	NNS
cord-280878-1kt51viz	37	25	have	have	VBP
cord-280878-1kt51viz	37	26	also	also	RB
cord-280878-1kt51viz	37	27	been	be	VBN
cord-280878-1kt51viz	37	28	reported	report	VBN
cord-280878-1kt51viz	37	29	for	for	IN
cord-280878-1kt51viz	37	30	coronavirus	coronavirus	NN
cord-280878-1kt51viz	37	31	envelope	envelope	NN
cord-280878-1kt51viz	37	32	proteins	protein	NNS
cord-280878-1kt51viz	37	33	(	(	-LRB-
cord-280878-1kt51viz	37	34	Verdia	Verdia	NNP
cord-280878-1kt51viz	37	35	-	-	HYPH
cord-280878-1kt51viz	37	36	Baguena	Baguena	NNP
cord-280878-1kt51viz	37	37	et	et	FW
cord-280878-1kt51viz	37	38	al	al	NNP
cord-280878-1kt51viz	37	39	.	.	NNP
cord-280878-1kt51viz	37	40	,	,	,
cord-280878-1kt51viz	37	41	2012	2012	CD
cord-280878-1kt51viz	37	42	)	)	-RRB-
cord-280878-1kt51viz	37	43	.	.	.
cord-280878-1kt51viz	38	1	In	in	IN
cord-280878-1kt51viz	38	2	the	the	DT
cord-280878-1kt51viz	38	3	quest	quest	NN
cord-280878-1kt51viz	38	4	to	to	TO
cord-280878-1kt51viz	38	5	discover	discover	VB
cord-280878-1kt51viz	38	6	small	small	JJ
cord-280878-1kt51viz	38	7	molecules	molecule	NNS
cord-280878-1kt51viz	38	8	targeting	target	VBG
cord-280878-1kt51viz	38	9	viroporins	viroporin	NNS
cord-280878-1kt51viz	38	10	,	,	,
cord-280878-1kt51viz	38	11	amantadine	amantadine	FW
cord-280878-1kt51viz	38	12	(	(	-LRB-
cord-280878-1kt51viz	38	13	Amt	Amt	NNP
cord-280878-1kt51viz	38	14	)	)	-RRB-
cord-280878-1kt51viz	38	15	can	can	MD
cord-280878-1kt51viz	38	16	be	be	VB
cord-280878-1kt51viz	38	17	considered	consider	VBN
cord-280878-1kt51viz	38	18	to	to	TO
cord-280878-1kt51viz	38	19	be	be	VB
cord-280878-1kt51viz	38	20	the	the	DT
cord-280878-1kt51viz	38	21	first	first	JJ
cord-280878-1kt51viz	38	22	viroporin	viroporin	NN
cord-280878-1kt51viz	38	23	channel	channel	NN
cord-280878-1kt51viz	38	24	inhibitor	inhibitor	NN
cord-280878-1kt51viz	38	25	,	,	,
cord-280878-1kt51viz	38	26	and	and	CC
cord-280878-1kt51viz	38	27	one	one	CD
cord-280878-1kt51viz	38	28	of	of	IN
cord-280878-1kt51viz	38	29	the	the	DT
cord-280878-1kt51viz	38	30	first	first	JJ
cord-280878-1kt51viz	38	31	antivirals	antiviral	NNS
cord-280878-1kt51viz	38	32	licensed	license	VBN
cord-280878-1kt51viz	38	33	for	for	IN
cord-280878-1kt51viz	38	34	use	use	NN
cord-280878-1kt51viz	38	35	in	in	IN
cord-280878-1kt51viz	38	36	humans	human	NNS
cord-280878-1kt51viz	38	37	.	.	.
cord-280878-1kt51viz	39	1	Although	although	IN
cord-280878-1kt51viz	39	2	it	-PRON-	PRP
cord-280878-1kt51viz	39	3	was	be	VBD
cord-280878-1kt51viz	39	4	known	know	VBN
cord-280878-1kt51viz	39	5	that	that	IN
cord-280878-1kt51viz	39	6	this	this	DT
cord-280878-1kt51viz	39	7	adamantane	adamantane	NNP
cord-280878-1kt51viz	39	8	was	be	VBD
cord-280878-1kt51viz	39	9	active	active	JJ
cord-280878-1kt51viz	39	10	against	against	IN
cord-280878-1kt51viz	39	11	IAV	IAV	NNP
cord-280878-1kt51viz	39	12	(	(	-LRB-
cord-280878-1kt51viz	39	13	Davies	Davies	NNP
cord-280878-1kt51viz	39	14	et	et	NNP
cord-280878-1kt51viz	39	15	al	al	NNP
cord-280878-1kt51viz	39	16	.	.	NNP
cord-280878-1kt51viz	39	17	,	,	,
cord-280878-1kt51viz	39	18	1964	1964	CD
cord-280878-1kt51viz	39	19	;	;	:
cord-280878-1kt51viz	39	20	Wingfield	Wingfield	NNP
cord-280878-1kt51viz	39	21	,	,	,
cord-280878-1kt51viz	39	22	Pollack	Pollack	NNP
cord-280878-1kt51viz	39	23	,	,	,
cord-280878-1kt51viz	39	24	&	&	CC
cord-280878-1kt51viz	39	25	Grunert	Grunert	NNP
cord-280878-1kt51viz	39	26	,	,	,
cord-280878-1kt51viz	39	27	1969	1969	CD
cord-280878-1kt51viz	39	28	)	)	-RRB-
cord-280878-1kt51viz	39	29	,	,	,
cord-280878-1kt51viz	39	30	the	the	DT
cord-280878-1kt51viz	39	31	mechanism	mechanism	NN
cord-280878-1kt51viz	39	32	of	of	IN
cord-280878-1kt51viz	39	33	inhibition	inhibition	NN
cord-280878-1kt51viz	39	34	was	be	VBD
cord-280878-1kt51viz	39	35	described	describe	VBN
cord-280878-1kt51viz	39	36	only	only	RB
cord-280878-1kt51viz	39	37	in	in	IN
cord-280878-1kt51viz	39	38	1992	1992	CD
cord-280878-1kt51viz	39	39	(	(	-LRB-
cord-280878-1kt51viz	39	40	Duff	Duff	NNP
cord-280878-1kt51viz	39	41	&	&	CC
cord-280878-1kt51viz	39	42	Ashley	Ashley	NNP
cord-280878-1kt51viz	39	43	,	,	,
cord-280878-1kt51viz	39	44	1992	1992	CD
cord-280878-1kt51viz	39	45	;	;	:
cord-280878-1kt51viz	39	46	Pinto	Pinto	NNP
cord-280878-1kt51viz	39	47	,	,	,
cord-280878-1kt51viz	39	48	Holsinger	Holsinger	NNP
cord-280878-1kt51viz	39	49	,	,	,
cord-280878-1kt51viz	39	50	&	&	CC
cord-280878-1kt51viz	39	51	Lamb	Lamb	NNP
cord-280878-1kt51viz	39	52	,	,	,
cord-280878-1kt51viz	39	53	1992	1992	CD
cord-280878-1kt51viz	39	54	)	)	-RRB-
cord-280878-1kt51viz	39	55	.	.	.
cord-280878-1kt51viz	40	1	The	the	DT
cord-280878-1kt51viz	40	2	target	target	NN
cord-280878-1kt51viz	40	3	itself	-PRON-	PRP
cord-280878-1kt51viz	40	4	,	,	,
cord-280878-1kt51viz	40	5	AM2	AM2	NNP
cord-280878-1kt51viz	40	6	,	,	,
cord-280878-1kt51viz	40	7	was	be	VBD
cord-280878-1kt51viz	40	8	not	not	RB
cord-280878-1kt51viz	40	9	known	know	VBN
cord-280878-1kt51viz	40	10	until	until	IN
cord-280878-1kt51viz	40	11	1985	1985	CD
cord-280878-1kt51viz	40	12	(	(	-LRB-
cord-280878-1kt51viz	40	13	Hay	Hay	NNP
cord-280878-1kt51viz	40	14	,	,	,
cord-280878-1kt51viz	40	15	Wolstenholme	Wolstenholme	NNP
cord-280878-1kt51viz	40	16	,	,	,
cord-280878-1kt51viz	40	17	Skehel	Skehel	NNP
cord-280878-1kt51viz	40	18	,	,	,
cord-280878-1kt51viz	40	19	&	&	CC
cord-280878-1kt51viz	40	20	Smith	Smith	NNP
cord-280878-1kt51viz	40	21	,	,	,
cord-280878-1kt51viz	40	22	1985	1985	CD
cord-280878-1kt51viz	40	23	)	)	-RRB-
cord-280878-1kt51viz	40	24	.	.	.
cord-280878-1kt51viz	41	1	Even	even	RB
cord-280878-1kt51viz	41	2	today	today	NN
cord-280878-1kt51viz	41	3	,	,	,
cord-280878-1kt51viz	41	4	Amt	Amt	NNP
cord-280878-1kt51viz	41	5	,	,	,
cord-280878-1kt51viz	41	6	together	together	RB
cord-280878-1kt51viz	41	7	with	with	IN
cord-280878-1kt51viz	41	8	its	-PRON-	PRP$
cord-280878-1kt51viz	41	9	methylated	methylated	JJ
cord-280878-1kt51viz	41	10	derivative	derivative	JJ
cord-280878-1kt51viz	41	11	rimantadine	rimantadine	NN
cord-280878-1kt51viz	41	12	(	(	-LRB-
cord-280878-1kt51viz	41	13	Rim	rim	NN
cord-280878-1kt51viz	41	14	)	)	-RRB-
cord-280878-1kt51viz	41	15	which	which	WDT
cord-280878-1kt51viz	41	16	was	be	VBD
cord-280878-1kt51viz	41	17	licensed	license	VBN
cord-280878-1kt51viz	41	18	in	in	IN
cord-280878-1kt51viz	41	19	the	the	DT
cord-280878-1kt51viz	41	20	1980s	1980	NNS
cord-280878-1kt51viz	41	21	,	,	,
cord-280878-1kt51viz	41	22	are	be	VBP
cord-280878-1kt51viz	41	23	the	the	DT
cord-280878-1kt51viz	41	24	only	only	RB
cord-280878-1kt51viz	41	25	licensed	license	VBN
cord-280878-1kt51viz	41	26	antiviral	antiviral	JJ
cord-280878-1kt51viz	41	27	drugs	drug	NNS
cord-280878-1kt51viz	41	28	that	that	WDT
cord-280878-1kt51viz	41	29	target	target	VBP
cord-280878-1kt51viz	41	30	viroporins	viroporin	NNS
cord-280878-1kt51viz	41	31	.	.	.
cord-280878-1kt51viz	42	1	This	this	DT
cord-280878-1kt51viz	42	2	contrasts	contrast	VBZ
cord-280878-1kt51viz	42	3	with	with	IN
cord-280878-1kt51viz	42	4	the	the	DT
cord-280878-1kt51viz	42	5	availability	availability	NN
cord-280878-1kt51viz	42	6	of	of	IN
cord-280878-1kt51viz	42	7	hundreds	hundred	NNS
cord-280878-1kt51viz	42	8	of	of	IN
cord-280878-1kt51viz	42	9	compounds	compound	NNS
cord-280878-1kt51viz	42	10	that	that	WDT
cord-280878-1kt51viz	42	11	exert	exert	VBP
cord-280878-1kt51viz	42	12	their	-PRON-	PRP$
cord-280878-1kt51viz	42	13	effects	effect	NNS
cord-280878-1kt51viz	42	14	with	with	IN
cord-280878-1kt51viz	42	15	subnanomolar	subnanomolar	JJ
cord-280878-1kt51viz	42	16	affinities	affinity	NNS
cord-280878-1kt51viz	42	17	on	on	IN
cord-280878-1kt51viz	42	18	nonviral	nonviral	JJ
cord-280878-1kt51viz	42	19	ion	ion	NN
cord-280878-1kt51viz	42	20	channels	channel	NNS
cord-280878-1kt51viz	42	21	.	.	.
cord-280878-1kt51viz	43	1	Although	although	IN
cord-280878-1kt51viz	43	2	this	this	DT
cord-280878-1kt51viz	43	3	phenomenon	phenomenon	NN
cord-280878-1kt51viz	43	4	could	could	MD
cord-280878-1kt51viz	43	5	be	be	VB
cord-280878-1kt51viz	43	6	explained	explain	VBN
cord-280878-1kt51viz	43	7	in	in	IN
cord-280878-1kt51viz	43	8	principle	principle	NN
cord-280878-1kt51viz	43	9	by	by	IN
cord-280878-1kt51viz	43	10	a	a	DT
cord-280878-1kt51viz	43	11	lack	lack	NN
cord-280878-1kt51viz	43	12	of	of	IN
cord-280878-1kt51viz	43	13	structural	structural	JJ
cord-280878-1kt51viz	43	14	data	datum	NNS
cord-280878-1kt51viz	43	15	for	for	IN
cord-280878-1kt51viz	43	16	viroporins	viroporin	NNS
cord-280878-1kt51viz	43	17	,	,	,
cord-280878-1kt51viz	43	18	this	this	DT
cord-280878-1kt51viz	43	19	is	be	VBZ
cord-280878-1kt51viz	43	20	not	not	RB
cord-280878-1kt51viz	43	21	the	the	DT
cord-280878-1kt51viz	43	22	case	case	NN
cord-280878-1kt51viz	43	23	for	for	IN
cord-280878-1kt51viz	43	24	AM2	AM2	NNP
cord-280878-1kt51viz	43	25	,	,	,
cord-280878-1kt51viz	43	26	where	where	WRB
cord-280878-1kt51viz	43	27	precise	precise	JJ
cord-280878-1kt51viz	43	28	structural	structural	JJ
cord-280878-1kt51viz	43	29	data	datum	NNS
cord-280878-1kt51viz	43	30	has	have	VBZ
cord-280878-1kt51viz	43	31	been	be	VBN
cord-280878-1kt51viz	43	32	obtained	obtain	VBN
cord-280878-1kt51viz	43	33	,	,	,
cord-280878-1kt51viz	43	34	even	even	RB
cord-280878-1kt51viz	43	35	for	for	IN
cord-280878-1kt51viz	43	36	some	some	DT
cord-280878-1kt51viz	43	37	of	of	IN
cord-280878-1kt51viz	43	38	its	-PRON-	PRP$
cord-280878-1kt51viz	43	39	Amt	amt	JJ
cord-280878-1kt51viz	43	40	-	-	HYPH
cord-280878-1kt51viz	43	41	resistant	resistant	JJ
cord-280878-1kt51viz	43	42	mutants	mutant	NNS
cord-280878-1kt51viz	43	43	Wang	Wang	NNP
cord-280878-1kt51viz	43	44	,	,	,
cord-280878-1kt51viz	43	45	Qiu	Qiu	NNP
cord-280878-1kt51viz	43	46	,	,	,
cord-280878-1kt51viz	43	47	Soto	Soto	NNP
cord-280878-1kt51viz	43	48	,	,	,
cord-280878-1kt51viz	43	49	&	&	CC
cord-280878-1kt51viz	43	50	Degrado	Degrado	NNP
cord-280878-1kt51viz	43	51	,	,	,
cord-280878-1kt51viz	43	52	2011	2011	CD
cord-280878-1kt51viz	43	53	)	)	-RRB-
cord-280878-1kt51viz	43	54	.	.	.
cord-280878-1kt51viz	44	1	Unfortunately	unfortunately	RB
cord-280878-1kt51viz	44	2	,	,	,
cord-280878-1kt51viz	44	3	an	an	DT
cord-280878-1kt51viz	44	4	effective	effective	JJ
cord-280878-1kt51viz	44	5	alternative	alternative	NN
cord-280878-1kt51viz	44	6	to	to	IN
cord-280878-1kt51viz	44	7	adamantanes	adamantanes	NNP
cord-280878-1kt51viz	44	8	has	have	VBZ
cord-280878-1kt51viz	44	9	not	not	RB
cord-280878-1kt51viz	44	10	yet	yet	RB
cord-280878-1kt51viz	44	11	been	be	VBN
cord-280878-1kt51viz	44	12	licensed	license	VBN
cord-280878-1kt51viz	44	13	.	.	.
cord-280878-1kt51viz	45	1	With	with	IN
cord-280878-1kt51viz	45	2	our	-PRON-	PRP$
cord-280878-1kt51viz	45	3	current	current	JJ
cord-280878-1kt51viz	45	4	knowledge	knowledge	NN
cord-280878-1kt51viz	45	5	,	,	,
cord-280878-1kt51viz	45	6	the	the	DT
cord-280878-1kt51viz	45	7	AM2	am2	JJ
cord-280878-1kt51viz	45	8	channel	channel	NN
cord-280878-1kt51viz	45	9	provides	provide	VBZ
cord-280878-1kt51viz	45	10	yet	yet	RB
cord-280878-1kt51viz	45	11	another	another	DT
cord-280878-1kt51viz	45	12	paradigm	paradigm	NN
cord-280878-1kt51viz	45	13	valid	valid	JJ
cord-280878-1kt51viz	45	14	for	for	IN
cord-280878-1kt51viz	45	15	other	other	JJ
cord-280878-1kt51viz	45	16	viroporins	viroporin	NNS
cord-280878-1kt51viz	45	17	.	.	.
cord-280878-1kt51viz	46	1	It	-PRON-	PRP
cord-280878-1kt51viz	46	2	has	have	VBZ
cord-280878-1kt51viz	46	3	a	a	DT
cord-280878-1kt51viz	46	4	very	very	RB
cord-280878-1kt51viz	46	5	simple	simple	JJ
cord-280878-1kt51viz	46	6	structure	structure	NN
cord-280878-1kt51viz	46	7	compared	compare	VBN
cord-280878-1kt51viz	46	8	to	to	IN
cord-280878-1kt51viz	46	9	ion	ion	NN
cord-280878-1kt51viz	46	10	channels	channel	NNS
cord-280878-1kt51viz	46	11	from	from	IN
cord-280878-1kt51viz	46	12	higher	high	JJR
cord-280878-1kt51viz	46	13	organisms	organism	NNS
cord-280878-1kt51viz	46	14	(	(	-LRB-
cord-280878-1kt51viz	46	15	such	such	JJ
cord-280878-1kt51viz	46	16	as	as	IN
cord-280878-1kt51viz	46	17	K	K	NNP
cord-280878-1kt51viz	46	18	+	+	CC
cord-280878-1kt51viz	47	1	and	and	CC
cord-280878-1kt51viz	47	2	Ca	Ca	NNP
cord-280878-1kt51viz	47	3	2	2	CD
cord-280878-1kt51viz	47	4	+	+	SYM
cord-280878-1kt51viz	47	5	channels	channel	NNS
cord-280878-1kt51viz	47	6	)	)	-RRB-
cord-280878-1kt51viz	47	7	,	,	.
cord-280878-1kt51viz	48	1	but	but	CC
cord-280878-1kt51viz	48	2	the	the	DT
cord-280878-1kt51viz	48	3	mechanism	mechanism	NN
cord-280878-1kt51viz	48	4	of	of	IN
cord-280878-1kt51viz	48	5	proton	proton	NN
cord-280878-1kt51viz	48	6	conduction	conduction	NN
cord-280878-1kt51viz	48	7	and	and	CC
cord-280878-1kt51viz	48	8	drugs	drug	NNS
cord-280878-1kt51viz	48	9	binding	bind	VBG
cord-280878-1kt51viz	48	10	and	and	CC
cord-280878-1kt51viz	48	11	inhibition	inhibition	NN
cord-280878-1kt51viz	48	12	are	be	VBP
cord-280878-1kt51viz	48	13	not	not	RB
cord-280878-1kt51viz	48	14	yet	yet	RB
cord-280878-1kt51viz	48	15	fully	fully	RB
cord-280878-1kt51viz	48	16	understood	understand	VBN
cord-280878-1kt51viz	48	17	.	.	.
cord-280878-1kt51viz	49	1	Indeed	indeed	RB
cord-280878-1kt51viz	49	2	,	,	,
cord-280878-1kt51viz	49	3	the	the	DT
cord-280878-1kt51viz	49	4	structural	structural	JJ
cord-280878-1kt51viz	49	5	and	and	CC
cord-280878-1kt51viz	49	6	functional	functional	JJ
cord-280878-1kt51viz	49	7	properties	property	NNS
cord-280878-1kt51viz	49	8	of	of	IN
cord-280878-1kt51viz	49	9	the	the	DT
cord-280878-1kt51viz	49	10	AM2	am2	JJ
cord-280878-1kt51viz	49	11	protein	protein	NN
cord-280878-1kt51viz	49	12	vary	vary	VBP
cord-280878-1kt51viz	49	13	widely	widely	RB
cord-280878-1kt51viz	49	14	in	in	IN
cord-280878-1kt51viz	49	15	changing	change	VBG
cord-280878-1kt51viz	49	16	experimental	experimental	JJ
cord-280878-1kt51viz	49	17	conditions	condition	NNS
cord-280878-1kt51viz	49	18	,	,	,
cord-280878-1kt51viz	49	19	such	such	JJ
cord-280878-1kt51viz	49	20	as	as	IN
cord-280878-1kt51viz	49	21	peptide	peptide	JJ
cord-280878-1kt51viz	49	22	length	length	NN
cord-280878-1kt51viz	49	23	,	,	,
cord-280878-1kt51viz	49	24	drug	drug	NN
cord-280878-1kt51viz	49	25	binding	binding	NN
cord-280878-1kt51viz	49	26	,	,	,
cord-280878-1kt51viz	49	27	lipid	lipid	NN
cord-280878-1kt51viz	49	28	composition	composition	NN
cord-280878-1kt51viz	49	29	,	,	,
cord-280878-1kt51viz	49	30	lipid	lipid	NN
cord-280878-1kt51viz	49	31	thickness	thickness	NN
cord-280878-1kt51viz	49	32	,	,	,
cord-280878-1kt51viz	49	33	or	or	CC
cord-280878-1kt51viz	49	34	pH	pH	NNP
cord-280878-1kt51viz	49	35	(	(	-LRB-
cord-280878-1kt51viz	49	36	Acharya	Acharya	NNP
cord-280878-1kt51viz	49	37	et	et	NNP
cord-280878-1kt51viz	49	38	al	al	NNP
cord-280878-1kt51viz	49	39	.	.	NNP
cord-280878-1kt51viz	49	40	,	,	,
cord-280878-1kt51viz	49	41	2010	2010	CD
cord-280878-1kt51viz	49	42	;	;	:
cord-280878-1kt51viz	49	43	Cady	Cady	NNP
cord-280878-1kt51viz	49	44	,	,	,
cord-280878-1kt51viz	49	45	Wang	Wang	NNP
cord-280878-1kt51viz	49	46	,	,	,
cord-280878-1kt51viz	49	47	&	&	CC
cord-280878-1kt51viz	49	48	Hong	Hong	NNP
cord-280878-1kt51viz	49	49	,	,	,
cord-280878-1kt51viz	49	50	2011	2011	CD
cord-280878-1kt51viz	49	51	;	;	:
cord-280878-1kt51viz	49	52	Cross	Cross	NNP
cord-280878-1kt51viz	49	53	et	et	FW
cord-280878-1kt51viz	49	54	al	al	NNP
cord-280878-1kt51viz	49	55	.	.	NNP
cord-280878-1kt51viz	49	56	,	,	,
cord-280878-1kt51viz	49	57	2012	2012	CD
cord-280878-1kt51viz	49	58	;	;	:
cord-280878-1kt51viz	49	59	Kovacs	Kovacs	NNP
cord-280878-1kt51viz	49	60	,	,	,
cord-280878-1kt51viz	49	61	Denny	Denny	NNP
cord-280878-1kt51viz	49	62	,	,	,
cord-280878-1kt51viz	49	63	Song	Song	NNP
cord-280878-1kt51viz	49	64	,	,	,
cord-280878-1kt51viz	49	65	Quine	Quine	NNP
cord-280878-1kt51viz	49	66	,	,	,
cord-280878-1kt51viz	49	67	&	&	CC
cord-280878-1kt51viz	49	68	Cross	Cross	NNP
cord-280878-1kt51viz	49	69	,	,	,
cord-280878-1kt51viz	49	70	2000	2000	CD
cord-280878-1kt51viz	49	71	;	;	:
cord-280878-1kt51viz	49	72	Thomaston	Thomaston	NNP
cord-280878-1kt51viz	49	73	et	et	NNP
cord-280878-1kt51viz	49	74	al	al	NNP
cord-280878-1kt51viz	49	75	.	.	NNP
cord-280878-1kt51viz	49	76	,	,	,
cord-280878-1kt51viz	49	77	2013	2013	CD
cord-280878-1kt51viz	49	78	;	;	:
cord-280878-1kt51viz	49	79	Zhou	Zhou	NNP
cord-280878-1kt51viz	49	80	&	&	CC
cord-280878-1kt51viz	49	81	Cross	Cross	NNP
cord-280878-1kt51viz	49	82	,	,	,
cord-280878-1kt51viz	49	83	2013	2013	CD
cord-280878-1kt51viz	49	84	)	)	-RRB-
cord-280878-1kt51viz	49	85	.	.	.
cord-280878-1kt51viz	50	1	An	an	DT
cord-280878-1kt51viz	50	2	important	important	JJ
cord-280878-1kt51viz	50	3	factor	factor	NN
cord-280878-1kt51viz	50	4	in	in	IN
cord-280878-1kt51viz	50	5	this	this	DT
cord-280878-1kt51viz	50	6	sensitivity	sensitivity	NN
cord-280878-1kt51viz	50	7	is	be	VBZ
cord-280878-1kt51viz	50	8	the	the	DT
cord-280878-1kt51viz	50	9	direct	direct	JJ
cord-280878-1kt51viz	50	10	contact	contact	NN
cord-280878-1kt51viz	50	11	of	of	IN
cord-280878-1kt51viz	50	12	its	-PRON-	PRP$
cord-280878-1kt51viz	50	13	TM	TM	NNP
cord-280878-1kt51viz	50	14	domains	domain	NNS
cord-280878-1kt51viz	50	15	with	with	IN
cord-280878-1kt51viz	50	16	the	the	DT
cord-280878-1kt51viz	50	17	lipid	lipid	NN
cord-280878-1kt51viz	50	18	molecules	molecule	NNS
cord-280878-1kt51viz	50	19	,	,	,
cord-280878-1kt51viz	50	20	in	in	IN
cord-280878-1kt51viz	50	21	contrast	contrast	NN
cord-280878-1kt51viz	50	22	to	to	IN
cord-280878-1kt51viz	50	23	higher	high	JJR
cord-280878-1kt51viz	50	24	organism	organism	NN
cord-280878-1kt51viz	50	25	ion	ion	NN
cord-280878-1kt51viz	50	26	channels	channel	NNS
cord-280878-1kt51viz	50	27	(	(	-LRB-
cord-280878-1kt51viz	50	28	eg	eg	UH
cord-280878-1kt51viz	50	29	,	,	,
cord-280878-1kt51viz	50	30	K	k	NN
cord-280878-1kt51viz	50	31	+	+	CC
cord-280878-1kt51viz	50	32	channels	channel	NNS
cord-280878-1kt51viz	50	33	)	)	-RRB-
cord-280878-1kt51viz	51	1	(	(	-LRB-
cord-280878-1kt51viz	51	2	Cuello	Cuello	NNP
cord-280878-1kt51viz	51	3	,	,	,
cord-280878-1kt51viz	51	4	Jogini	Jogini	NNP
cord-280878-1kt51viz	51	5	,	,	,
cord-280878-1kt51viz	51	6	Cortes	Cortes	NNP
cord-280878-1kt51viz	51	7	,	,	,
cord-280878-1kt51viz	51	8	&	&	CC
cord-280878-1kt51viz	51	9	Perozo	Perozo	NNP
cord-280878-1kt51viz	51	10	,	,	,
cord-280878-1kt51viz	51	11	2010	2010	CD
cord-280878-1kt51viz	51	12	)	)	-RRB-
cord-280878-1kt51viz	51	13	,	,	,
cord-280878-1kt51viz	51	14	where	where	WRB
cord-280878-1kt51viz	51	15	pore	pore	NN
cord-280878-1kt51viz	51	16	-	-	HYPH
cord-280878-1kt51viz	51	17	forming	form	VBG
cord-280878-1kt51viz	51	18	α	α	NN
cord-280878-1kt51viz	51	19	-	-	HYPH
cord-280878-1kt51viz	51	20	helices	helix	NNS
cord-280878-1kt51viz	51	21	are	be	VBP
cord-280878-1kt51viz	51	22	surrounded	surround	VBN
cord-280878-1kt51viz	51	23	and	and	CC
cord-280878-1kt51viz	51	24	protected	protect	VBN
cord-280878-1kt51viz	51	25	by	by	IN
cord-280878-1kt51viz	51	26	additional	additional	JJ
cord-280878-1kt51viz	51	27	transmembrane	transmembrane	NN
cord-280878-1kt51viz	51	28	helices	helix	NNS
cord-280878-1kt51viz	51	29	.	.	.
cord-280878-1kt51viz	52	1	However	however	RB
cord-280878-1kt51viz	52	2	,	,	,
cord-280878-1kt51viz	52	3	while	while	IN
cord-280878-1kt51viz	52	4	the	the	DT
cord-280878-1kt51viz	52	5	AM2	am2	JJ
cord-280878-1kt51viz	52	6	channel	channel	NN
cord-280878-1kt51viz	52	7	exists	exist	VBZ
cord-280878-1kt51viz	52	8	in	in	IN
cord-280878-1kt51viz	52	9	a	a	DT
cord-280878-1kt51viz	52	10	variety	variety	NN
cord-280878-1kt51viz	52	11	of	of	IN
cord-280878-1kt51viz	52	12	conformational	conformational	JJ
cord-280878-1kt51viz	52	13	states	state	NNS
cord-280878-1kt51viz	52	14	in	in	IN
cord-280878-1kt51viz	52	15	the	the	DT
cord-280878-1kt51viz	52	16	apo	apo	NNP
cord-280878-1kt51viz	52	17	-	-	HYPH
cord-280878-1kt51viz	52	18	form	form	NN
cord-280878-1kt51viz	52	19	,	,	,
cord-280878-1kt51viz	52	20	inhibitor	inhibitor	NN
cord-280878-1kt51viz	52	21	-	-	HYPH
cord-280878-1kt51viz	52	22	binding	bind	VBG
cord-280878-1kt51viz	52	23	significantly	significantly	RB
cord-280878-1kt51viz	52	24	reduces	reduce	VBZ
cord-280878-1kt51viz	52	25	the	the	DT
cord-280878-1kt51viz	52	26	conformational	conformational	JJ
cord-280878-1kt51viz	52	27	flexibility	flexibility	NN
cord-280878-1kt51viz	52	28	of	of	IN
cord-280878-1kt51viz	52	29	the	the	DT
cord-280878-1kt51viz	52	30	channel	channel	NN
cord-280878-1kt51viz	52	31	.	.	.
cord-280878-1kt51viz	53	1	The	the	DT
cord-280878-1kt51viz	53	2	structural	structural	JJ
cord-280878-1kt51viz	53	3	dynamics	dynamic	NNS
cord-280878-1kt51viz	53	4	of	of	IN
cord-280878-1kt51viz	53	5	the	the	DT
cord-280878-1kt51viz	53	6	channel	channel	NN
cord-280878-1kt51viz	53	7	represents	represent	VBZ
cord-280878-1kt51viz	53	8	another	another	DT
cord-280878-1kt51viz	53	9	drawback	drawback	NN
cord-280878-1kt51viz	53	10	in	in	IN
cord-280878-1kt51viz	53	11	the	the	DT
cord-280878-1kt51viz	53	12	use	use	NN
cord-280878-1kt51viz	53	13	of	of	IN
cord-280878-1kt51viz	53	14	high	high	JJ
cord-280878-1kt51viz	53	15	-	-	HYPH
cord-280878-1kt51viz	53	16	resolution	resolution	NN
cord-280878-1kt51viz	53	17	structures	structure	NNS
cord-280878-1kt51viz	53	18	for	for	IN
cord-280878-1kt51viz	53	19	rationally	rationally	RB
cord-280878-1kt51viz	53	20	designed	design	VBN
cord-280878-1kt51viz	53	21	drug	drug	NN
cord-280878-1kt51viz	53	22	discovery	discovery	NN
cord-280878-1kt51viz	53	23	.	.	.
cord-280878-1kt51viz	54	1	Amantadine	Amantadine	NNP
cord-280878-1kt51viz	54	2	is	be	VBZ
cord-280878-1kt51viz	54	3	just	just	RB
cord-280878-1kt51viz	54	4	one	one	CD
cord-280878-1kt51viz	54	5	of	of	IN
cord-280878-1kt51viz	54	6	the	the	DT
cord-280878-1kt51viz	54	7	four	four	CD
cord-280878-1kt51viz	54	8	antivirals	antiviral	NNS
cord-280878-1kt51viz	54	9	against	against	IN
cord-280878-1kt51viz	54	10	IAV	IAV	NNP
cord-280878-1kt51viz	54	11	available	available	JJ
cord-280878-1kt51viz	54	12	:	:	:
cord-280878-1kt51viz	54	13	two	two	CD
cord-280878-1kt51viz	54	14	neuraminidase	neuraminidase	NN
cord-280878-1kt51viz	54	15	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	54	16	(	(	-LRB-
cord-280878-1kt51viz	54	17	oseltamivir	oseltamivir	NNP
cord-280878-1kt51viz	54	18	and	and	CC
cord-280878-1kt51viz	54	19	zanamivir	zanamivir	NNP
cord-280878-1kt51viz	54	20	)	)	-RRB-
cord-280878-1kt51viz	54	21	and	and	CC
cord-280878-1kt51viz	54	22	two	two	CD
cord-280878-1kt51viz	54	23	AM2	am2	JJ
cord-280878-1kt51viz	54	24	channel	channel	NN
cord-280878-1kt51viz	54	25	blockers	blocker	NNS
cord-280878-1kt51viz	54	26	(	(	-LRB-
cord-280878-1kt51viz	54	27	Amt	Amt	NNP
cord-280878-1kt51viz	54	28	and	and	CC
cord-280878-1kt51viz	54	29	Rim	Rim	NNP
cord-280878-1kt51viz	54	30	)	)	-RRB-
cord-280878-1kt51viz	54	31	(	(	-LRB-
cord-280878-1kt51viz	54	32	Vanderlinden	Vanderlinden	NNP
cord-280878-1kt51viz	54	33	&	&	CC
cord-280878-1kt51viz	54	34	Naesens	Naesens	NNP
cord-280878-1kt51viz	54	35	,	,	,
cord-280878-1kt51viz	54	36	2014	2014	CD
cord-280878-1kt51viz	54	37	)	)	-RRB-
cord-280878-1kt51viz	54	38	.	.	.
cord-280878-1kt51viz	55	1	The	the	DT
cord-280878-1kt51viz	55	2	seasonal	seasonal	JJ
cord-280878-1kt51viz	55	3	flu	flu	NN
cord-280878-1kt51viz	55	4	caused	cause	VBN
cord-280878-1kt51viz	55	5	by	by	IN
cord-280878-1kt51viz	55	6	IAV	IAV	NNP
cord-280878-1kt51viz	55	7	is	be	VBZ
cord-280878-1kt51viz	55	8	associated	associate	VBN
cord-280878-1kt51viz	55	9	with	with	IN
cord-280878-1kt51viz	55	10	high	high	JJ
cord-280878-1kt51viz	55	11	medical	medical	JJ
cord-280878-1kt51viz	55	12	burden	burden	NN
cord-280878-1kt51viz	55	13	(	(	-LRB-
cord-280878-1kt51viz	55	14	Molinari	Molinari	NNP
cord-280878-1kt51viz	55	15	et	et	NNP
cord-280878-1kt51viz	55	16	al	al	NNP
cord-280878-1kt51viz	55	17	.	.	NNP
cord-280878-1kt51viz	55	18	,	,	,
cord-280878-1kt51viz	55	19	2007	2007	CD
cord-280878-1kt51viz	55	20	)	)	-RRB-
cord-280878-1kt51viz	55	21	and	and	CC
cord-280878-1kt51viz	55	22	sudden	sudden	JJ
cord-280878-1kt51viz	55	23	pandemics	pandemic	NNS
cord-280878-1kt51viz	55	24	with	with	IN
cord-280878-1kt51viz	55	25	high	high	JJ
cord-280878-1kt51viz	55	26	mortality	mortality	NN
cord-280878-1kt51viz	55	27	rates	rate	NNS
cord-280878-1kt51viz	55	28	(	(	-LRB-
cord-280878-1kt51viz	55	29	Hay	Hay	NNP
cord-280878-1kt51viz	55	30	,	,	,
cord-280878-1kt51viz	55	31	Gregory	Gregory	NNP
cord-280878-1kt51viz	55	32	,	,	,
cord-280878-1kt51viz	55	33	Douglas	Douglas	NNP
cord-280878-1kt51viz	55	34	,	,	,
cord-280878-1kt51viz	55	35	&	&	CC
cord-280878-1kt51viz	55	36	Yi	Yi	NNP
cord-280878-1kt51viz	55	37	,	,	,
cord-280878-1kt51viz	55	38	2001	2001	CD
cord-280878-1kt51viz	55	39	;	;	:
cord-280878-1kt51viz	55	40	Neumann	Neumann	NNP
cord-280878-1kt51viz	55	41	,	,	,
cord-280878-1kt51viz	55	42	Noda	Noda	NNP
cord-280878-1kt51viz	55	43	,	,	,
cord-280878-1kt51viz	55	44	&	&	CC
cord-280878-1kt51viz	55	45	Kawaoka	Kawaoka	NNP
cord-280878-1kt51viz	55	46	,	,	,
cord-280878-1kt51viz	55	47	2009	2009	CD
cord-280878-1kt51viz	55	48	)	)	-RRB-
cord-280878-1kt51viz	55	49	.	.	.
cord-280878-1kt51viz	56	1	Currently	currently	RB
cord-280878-1kt51viz	56	2	,	,	,
cord-280878-1kt51viz	56	3	most	most	RBS
cord-280878-1kt51viz	56	4	circulating	circulating	JJ
cord-280878-1kt51viz	56	5	strains	strain	NNS
cord-280878-1kt51viz	56	6	are	be	VBP
cord-280878-1kt51viz	56	7	Amt	Amt	NNP
cord-280878-1kt51viz	56	8	resistant	resistant	JJ
cord-280878-1kt51viz	56	9	(	(	-LRB-
cord-280878-1kt51viz	56	10	Bright	bright	JJ
cord-280878-1kt51viz	56	11	,	,	,
cord-280878-1kt51viz	56	12	Shay	Shay	NNP
cord-280878-1kt51viz	56	13	,	,	,
cord-280878-1kt51viz	56	14	Shu	Shu	NNP
cord-280878-1kt51viz	56	15	,	,	,
cord-280878-1kt51viz	56	16	Cox	Cox	NNP
cord-280878-1kt51viz	56	17	,	,	,
cord-280878-1kt51viz	56	18	&	&	CC
cord-280878-1kt51viz	56	19	Klimov	Klimov	NNP
cord-280878-1kt51viz	56	20	,	,	,
cord-280878-1kt51viz	56	21	2006	2006	CD
cord-280878-1kt51viz	56	22	;	;	.
cord-280878-1kt51viz	57	1	Bright	bright	JJ
cord-280878-1kt51viz	57	2	et	et	FW
cord-280878-1kt51viz	57	3	al	al	NNP
cord-280878-1kt51viz	57	4	.	.	.
cord-280878-1kt51viz	58	1	,	,	,
cord-280878-1kt51viz	58	2	2005	2005	CD
cord-280878-1kt51viz	58	3	;	;	:
cord-280878-1kt51viz	58	4	Deyde	Deyde	NNP
cord-280878-1kt51viz	58	5	et	et	NNP
cord-280878-1kt51viz	58	6	al	al	NNP
cord-280878-1kt51viz	58	7	.	.	NNP
cord-280878-1kt51viz	58	8	,	,	,
cord-280878-1kt51viz	58	9	2007	2007	CD
cord-280878-1kt51viz	58	10	;	;	:
cord-280878-1kt51viz	58	11	Hayden	Hayden	NNP
cord-280878-1kt51viz	58	12	&	&	CC
cord-280878-1kt51viz	58	13	De	De	NNP
cord-280878-1kt51viz	58	14	Jong	Jong	NNP
cord-280878-1kt51viz	58	15	,	,	,
cord-280878-1kt51viz	58	16	2011	2011	CD
cord-280878-1kt51viz	58	17	)	)	-RRB-
cord-280878-1kt51viz	58	18	and	and	CC
cord-280878-1kt51viz	58	19	therefore	therefore	RB
cord-280878-1kt51viz	58	20	the	the	DT
cord-280878-1kt51viz	58	21	use	use	NN
cord-280878-1kt51viz	58	22	of	of	IN
cord-280878-1kt51viz	58	23	Amt	Amt	NNP
cord-280878-1kt51viz	58	24	and	and	CC
cord-280878-1kt51viz	58	25	Rim	Rim	NNP
cord-280878-1kt51viz	58	26	has	have	VBZ
cord-280878-1kt51viz	58	27	been	be	VBN
cord-280878-1kt51viz	58	28	discontinued	discontinue	VBN
cord-280878-1kt51viz	58	29	for	for	IN
cord-280878-1kt51viz	58	30	the	the	DT
cord-280878-1kt51viz	58	31	human	human	JJ
cord-280878-1kt51viz	58	32	population	population	NN
cord-280878-1kt51viz	58	33	(	(	-LRB-
cord-280878-1kt51viz	58	34	Fiore	Fiore	NNP
cord-280878-1kt51viz	58	35	et	et	FW
cord-280878-1kt51viz	58	36	al	al	NNP
cord-280878-1kt51viz	58	37	.	.	.
cord-280878-1kt51viz	59	1	,	,	,
cord-280878-1kt51viz	59	2	2011	2011	CD
cord-280878-1kt51viz	59	3	)	)	-RRB-
cord-280878-1kt51viz	59	4	.	.	.
cord-280878-1kt51viz	60	1	The	the	DT
cord-280878-1kt51viz	60	2	AM2	am2	JJ
cord-280878-1kt51viz	60	3	channel	channel	NN
cord-280878-1kt51viz	60	4	is	be	VBZ
cord-280878-1kt51viz	60	5	a	a	DT
cord-280878-1kt51viz	60	6	homotetramer	homotetramer	NNP
cord-280878-1kt51viz	60	7	(	(	-LRB-
cord-280878-1kt51viz	60	8	Sakaguchi	Sakaguchi	NNP
cord-280878-1kt51viz	60	9	,	,	,
cord-280878-1kt51viz	60	10	Tu	Tu	NNP
cord-280878-1kt51viz	60	11	,	,	,
cord-280878-1kt51viz	60	12	Pinto	Pinto	NNP
cord-280878-1kt51viz	60	13	,	,	,
cord-280878-1kt51viz	60	14	&	&	CC
cord-280878-1kt51viz	60	15	Lamb	Lamb	NNP
cord-280878-1kt51viz	60	16	,	,	,
cord-280878-1kt51viz	60	17	1997	1997	CD
cord-280878-1kt51viz	60	18	)	)	-RRB-
cord-280878-1kt51viz	60	19	,	,	,
cord-280878-1kt51viz	60	20	where	where	WRB
cord-280878-1kt51viz	60	21	each	each	DT
cord-280878-1kt51viz	60	22	monomer	monomer	NN
cord-280878-1kt51viz	60	23	has	have	VBZ
cord-280878-1kt51viz	60	24	97	97	CD
cord-280878-1kt51viz	60	25	amino	amino	NN
cord-280878-1kt51viz	60	26	acids	acid	NNS
cord-280878-1kt51viz	60	27	containing	contain	VBG
cord-280878-1kt51viz	60	28	one	one	CD
cord-280878-1kt51viz	60	29	α	α	NN
cord-280878-1kt51viz	60	30	-	-	HYPH
cord-280878-1kt51viz	60	31	helical	helical	JJ
cord-280878-1kt51viz	60	32	TM	TM	NNP
cord-280878-1kt51viz	60	33	domain	domain	NN
cord-280878-1kt51viz	60	34	(	(	-LRB-
cord-280878-1kt51viz	60	35	residues	residue	NNS
cord-280878-1kt51viz	60	36	25	25	CD
cord-280878-1kt51viz	60	37	-	-	SYM
cord-280878-1kt51viz	60	38	46	46	CD
cord-280878-1kt51viz	60	39	)	)	-RRB-
cord-280878-1kt51viz	60	40	.	.	.
cord-280878-1kt51viz	61	1	The	the	DT
cord-280878-1kt51viz	61	2	extramembrane	extramembrane	NNP
cord-280878-1kt51viz	61	3	C	C	NNP
cord-280878-1kt51viz	61	4	-	-	HYPH
cord-280878-1kt51viz	61	5	terminal	terminal	NN
cord-280878-1kt51viz	61	6	domain	domain	NN
cord-280878-1kt51viz	61	7	(	(	-LRB-
cord-280878-1kt51viz	61	8	residues	residue	NNS
cord-280878-1kt51viz	61	9	47	47	CD
cord-280878-1kt51viz	61	10	-	-	SYM
cord-280878-1kt51viz	61	11	97	97	CD
cord-280878-1kt51viz	61	12	)	)	-RRB-
cord-280878-1kt51viz	61	13	is	be	VBZ
cord-280878-1kt51viz	61	14	exposed	expose	VBN
cord-280878-1kt51viz	61	15	to	to	IN
cord-280878-1kt51viz	61	16	the	the	DT
cord-280878-1kt51viz	61	17	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	61	18	side	side	NN
cord-280878-1kt51viz	61	19	(	(	-LRB-
cord-280878-1kt51viz	61	20	Lamb	Lamb	NNP
cord-280878-1kt51viz	61	21	,	,	,
cord-280878-1kt51viz	61	22	Zebedee	Zebedee	NNP
cord-280878-1kt51viz	61	23	,	,	,
cord-280878-1kt51viz	61	24	&	&	CC
cord-280878-1kt51viz	61	25	Richardson	Richardson	NNP
cord-280878-1kt51viz	61	26	,	,	,
cord-280878-1kt51viz	61	27	1985	1985	CD
cord-280878-1kt51viz	61	28	)	)	-RRB-
cord-280878-1kt51viz	61	29	and	and	CC
cord-280878-1kt51viz	61	30	contains	contain	VBZ
cord-280878-1kt51viz	61	31	an	an	DT
cord-280878-1kt51viz	61	32	amphipathic	amphipathic	JJ
cord-280878-1kt51viz	61	33	helix	helix	NN
cord-280878-1kt51viz	61	34	(	(	-LRB-
cord-280878-1kt51viz	61	35	residues	residue	NNS
cord-280878-1kt51viz	61	36	51	51	CD
cord-280878-1kt51viz	61	37	-	-	SYM
cord-280878-1kt51viz	61	38	59	59	CD
cord-280878-1kt51viz	61	39	)	)	-RRB-
cord-280878-1kt51viz	61	40	.	.	.
cord-280878-1kt51viz	62	1	Four	four	CD
cord-280878-1kt51viz	62	2	of	of	IN
cord-280878-1kt51viz	62	3	these	these	DT
cord-280878-1kt51viz	62	4	amphipathic	amphipathic	JJ
cord-280878-1kt51viz	62	5	helices	helix	NNS
cord-280878-1kt51viz	62	6	stabilize	stabilize	VBP
cord-280878-1kt51viz	62	7	the	the	DT
cord-280878-1kt51viz	62	8	tetrameric	tetrameric	JJ
cord-280878-1kt51viz	62	9	channel	channel	NN
cord-280878-1kt51viz	62	10	,	,	,
cord-280878-1kt51viz	62	11	forming	form	VBG
cord-280878-1kt51viz	62	12	a	a	DT
cord-280878-1kt51viz	62	13	base	base	NN
cord-280878-1kt51viz	62	14	on	on	IN
cord-280878-1kt51viz	62	15	the	the	DT
cord-280878-1kt51viz	62	16	membrane	membrane	NN
cord-280878-1kt51viz	62	17	surface	surface	NN
cord-280878-1kt51viz	62	18	almost	almost	RB
cord-280878-1kt51viz	62	19	perpendicular	perpendicular	JJ
cord-280878-1kt51viz	62	20	to	to	IN
cord-280878-1kt51viz	62	21	the	the	DT
cord-280878-1kt51viz	62	22	TM	TM	NNP
cord-280878-1kt51viz	62	23	bundle	bundle	NN
cord-280878-1kt51viz	62	24	.	.	.
cord-280878-1kt51viz	63	1	The	the	DT
cord-280878-1kt51viz	63	2	end	end	NN
cord-280878-1kt51viz	63	3	of	of	IN
cord-280878-1kt51viz	63	4	this	this	DT
cord-280878-1kt51viz	63	5	C	c	NN
cord-280878-1kt51viz	63	6	-	-	HYPH
cord-280878-1kt51viz	63	7	terminal	terminal	NN
cord-280878-1kt51viz	63	8	tail	tail	NN
cord-280878-1kt51viz	63	9	is	be	VBZ
cord-280878-1kt51viz	63	10	disordered	disordered	JJ
cord-280878-1kt51viz	63	11	and	and	CC
cord-280878-1kt51viz	63	12	interacts	interact	VBZ
cord-280878-1kt51viz	63	13	with	with	IN
cord-280878-1kt51viz	63	14	the	the	DT
cord-280878-1kt51viz	63	15	viral	viral	JJ
cord-280878-1kt51viz	63	16	matrix	matrix	NN
cord-280878-1kt51viz	63	17	protein	protein	NN
cord-280878-1kt51viz	63	18	1	1	CD
cord-280878-1kt51viz	63	19	(	(	-LRB-
cord-280878-1kt51viz	63	20	M1	M1	NNP
cord-280878-1kt51viz	63	21	)	)	-RRB-
cord-280878-1kt51viz	63	22	.	.	.
cord-280878-1kt51viz	64	1	The	the	DT
cord-280878-1kt51viz	64	2	M2	M2	NNP
cord-280878-1kt51viz	64	3	protein	protein	NN
cord-280878-1kt51viz	64	4	performs	perform	VBZ
cord-280878-1kt51viz	64	5	several	several	JJ
cord-280878-1kt51viz	64	6	critical	critical	JJ
cord-280878-1kt51viz	64	7	roles	role	NNS
cord-280878-1kt51viz	64	8	for	for	IN
cord-280878-1kt51viz	64	9	virus	virus	NN
cord-280878-1kt51viz	64	10	replication	replication	NN
cord-280878-1kt51viz	64	11	(	(	-LRB-
cord-280878-1kt51viz	64	12	Pinto	Pinto	NNP
cord-280878-1kt51viz	64	13	&	&	CC
cord-280878-1kt51viz	64	14	Lamb	Lamb	NNP
cord-280878-1kt51viz	64	15	,	,	,
cord-280878-1kt51viz	64	16	2006	2006	CD
cord-280878-1kt51viz	64	17	)	)	-RRB-
cord-280878-1kt51viz	64	18	.	.	.
cord-280878-1kt51viz	65	1	For	for	IN
cord-280878-1kt51viz	65	2	instance	instance	NN
cord-280878-1kt51viz	65	3	,	,	,
cord-280878-1kt51viz	65	4	M2-mediated	m2-mediated	JJ
cord-280878-1kt51viz	65	5	acidification	acidification	NN
cord-280878-1kt51viz	65	6	of	of	IN
cord-280878-1kt51viz	65	7	the	the	DT
cord-280878-1kt51viz	65	8	interior	interior	NN
cord-280878-1kt51viz	65	9	of	of	IN
cord-280878-1kt51viz	65	10	the	the	DT
cord-280878-1kt51viz	65	11	virus	virus	NN
cord-280878-1kt51viz	65	12	is	be	VBZ
cord-280878-1kt51viz	65	13	required	require	VBN
cord-280878-1kt51viz	65	14	for	for	IN
cord-280878-1kt51viz	65	15	the	the	DT
cord-280878-1kt51viz	65	16	uncoating	uncoating	NN
cord-280878-1kt51viz	65	17	of	of	IN
cord-280878-1kt51viz	65	18	genetic	genetic	JJ
cord-280878-1kt51viz	65	19	material	material	NN
cord-280878-1kt51viz	65	20	inside	inside	IN
cord-280878-1kt51viz	65	21	the	the	DT
cord-280878-1kt51viz	65	22	cell	cell	NN
cord-280878-1kt51viz	65	23	(	(	-LRB-
cord-280878-1kt51viz	65	24	Pinto	Pinto	NNP
cord-280878-1kt51viz	65	25	et	et	NNP
cord-280878-1kt51viz	65	26	al	al	NNP
cord-280878-1kt51viz	65	27	.	.	NNP
cord-280878-1kt51viz	65	28	,	,	,
cord-280878-1kt51viz	65	29	1992	1992	CD
cord-280878-1kt51viz	65	30	)	)	-RRB-
cord-280878-1kt51viz	65	31	.	.	.
cord-280878-1kt51viz	66	1	M2	M2	NNP
cord-280878-1kt51viz	66	2	is	be	VBZ
cord-280878-1kt51viz	66	3	also	also	RB
cord-280878-1kt51viz	66	4	required	require	VBN
cord-280878-1kt51viz	66	5	to	to	TO
cord-280878-1kt51viz	66	6	regulate	regulate	VB
cord-280878-1kt51viz	66	7	the	the	DT
cord-280878-1kt51viz	66	8	intralumenal	intralumenal	NNP
cord-280878-1kt51viz	66	9	pH	ph	NN
cord-280878-1kt51viz	66	10	of	of	IN
cord-280878-1kt51viz	66	11	the	the	DT
cord-280878-1kt51viz	66	12	Golgi	Golgi	NNP
cord-280878-1kt51viz	66	13	apparatus	apparatus	NN
cord-280878-1kt51viz	66	14	preventing	prevent	VBG
cord-280878-1kt51viz	66	15	the	the	DT
cord-280878-1kt51viz	66	16	premature	premature	JJ
cord-280878-1kt51viz	66	17	conformational	conformational	JJ
cord-280878-1kt51viz	66	18	change	change	NN
cord-280878-1kt51viz	66	19	of	of	IN
cord-280878-1kt51viz	66	20	hemagglutinin	hemagglutinin	NN
cord-280878-1kt51viz	66	21	(	(	-LRB-
cord-280878-1kt51viz	66	22	Takeuchi	Takeuchi	NNP
cord-280878-1kt51viz	66	23	&	&	CC
cord-280878-1kt51viz	66	24	Lamb	Lamb	NNP
cord-280878-1kt51viz	66	25	,	,	,
cord-280878-1kt51viz	66	26	1994	1994	CD
cord-280878-1kt51viz	66	27	)	)	-RRB-
cord-280878-1kt51viz	66	28	.	.	.
cord-280878-1kt51viz	67	1	Influenza	Influenza	NNP
cord-280878-1kt51viz	67	2	B	B	NNP
cord-280878-1kt51viz	67	3	,	,	,
cord-280878-1kt51viz	67	4	the	the	DT
cord-280878-1kt51viz	67	5	closest	close	JJS
cord-280878-1kt51viz	67	6	relative	relative	NN
cord-280878-1kt51viz	67	7	of	of	IN
cord-280878-1kt51viz	67	8	the	the	DT
cord-280878-1kt51viz	67	9	influenza	influenza	NN
cord-280878-1kt51viz	67	10	A	a	DT
cord-280878-1kt51viz	67	11	virus	virus	NN
cord-280878-1kt51viz	67	12	,	,	,
cord-280878-1kt51viz	67	13	accounts	account	VBZ
cord-280878-1kt51viz	67	14	for	for	IN
cord-280878-1kt51viz	67	15	about	about	RB
cord-280878-1kt51viz	67	16	50	50	CD
cord-280878-1kt51viz	67	17	%	%	NN
cord-280878-1kt51viz	67	18	of	of	IN
cord-280878-1kt51viz	67	19	all	all	DT
cord-280878-1kt51viz	67	20	influenza	influenza	NN
cord-280878-1kt51viz	67	21	disease	disease	NN
cord-280878-1kt51viz	67	22	in	in	IN
cord-280878-1kt51viz	67	23	recent	recent	JJ
cord-280878-1kt51viz	67	24	years	year	NNS
cord-280878-1kt51viz	67	25	(	(	-LRB-
cord-280878-1kt51viz	67	26	according	accord	VBG
cord-280878-1kt51viz	67	27	to	to	IN
cord-280878-1kt51viz	67	28	the	the	DT
cord-280878-1kt51viz	67	29	US	US	NNP
cord-280878-1kt51viz	67	30	Centers	Centers	NNPS
cord-280878-1kt51viz	67	31	for	for	IN
cord-280878-1kt51viz	67	32	Disease	Disease	NNP
cord-280878-1kt51viz	67	33	Control	Control	NNP
cord-280878-1kt51viz	67	34	and	and	CC
cord-280878-1kt51viz	67	35	Prevention	Prevention	NNP
cord-280878-1kt51viz	67	36	website	website	NN
cord-280878-1kt51viz	67	37	,	,	,
cord-280878-1kt51viz	67	38	www.cdc.gov	www.cdc.gov	NNP
cord-280878-1kt51viz	67	39	)	)	-RRB-
cord-280878-1kt51viz	67	40	and	and	CC
cord-280878-1kt51viz	67	41	has	have	VBZ
cord-280878-1kt51viz	67	42	a	a	DT
cord-280878-1kt51viz	67	43	similarly	similarly	RB
cord-280878-1kt51viz	67	44	essential	essential	JJ
cord-280878-1kt51viz	67	45	pH	ph	NN
cord-280878-1kt51viz	67	46	-	-	HYPH
cord-280878-1kt51viz	67	47	activated	activate	VBN
cord-280878-1kt51viz	67	48	proton	proton	NN
cord-280878-1kt51viz	67	49	channel	channel	NN
cord-280878-1kt51viz	67	50	M2	M2	NNP
cord-280878-1kt51viz	67	51	viroporin	viroporin	NNP
cord-280878-1kt51viz	67	52	,	,	,
cord-280878-1kt51viz	67	53	the	the	DT
cord-280878-1kt51viz	67	54	BM2	BM2	NNP
cord-280878-1kt51viz	67	55	(	(	-LRB-
cord-280878-1kt51viz	67	56	Hatta	Hatta	NNP
cord-280878-1kt51viz	67	57	,	,	,
cord-280878-1kt51viz	67	58	Goto	Goto	NNP
cord-280878-1kt51viz	67	59	,	,	,
cord-280878-1kt51viz	67	60	&	&	CC
cord-280878-1kt51viz	67	61	Kawaoka	Kawaoka	NNP
cord-280878-1kt51viz	67	62	,	,	,
cord-280878-1kt51viz	67	63	2004	2004	CD
cord-280878-1kt51viz	67	64	;	;	:
cord-280878-1kt51viz	67	65	Pinto	Pinto	NNP
cord-280878-1kt51viz	67	66	&	&	CC
cord-280878-1kt51viz	67	67	Lamb	Lamb	NNP
cord-280878-1kt51viz	67	68	,	,	,
cord-280878-1kt51viz	67	69	2006	2006	CD
cord-280878-1kt51viz	67	70	)	)	-RRB-
cord-280878-1kt51viz	67	71	.	.	.
cord-280878-1kt51viz	68	1	Although	although	IN
cord-280878-1kt51viz	68	2	AM2	AM2	NNP
cord-280878-1kt51viz	68	3	and	and	CC
cord-280878-1kt51viz	68	4	BM2	BM2	NNP
cord-280878-1kt51viz	68	5	share	share	VBP
cord-280878-1kt51viz	68	6	almost	almost	RB
cord-280878-1kt51viz	68	7	no	no	DT
cord-280878-1kt51viz	68	8	sequence	sequence	NN
cord-280878-1kt51viz	68	9	identity	identity	NN
cord-280878-1kt51viz	68	10	,	,	,
cord-280878-1kt51viz	68	11	both	both	DT
cord-280878-1kt51viz	68	12	have	have	VBP
cord-280878-1kt51viz	68	13	a	a	DT
cord-280878-1kt51viz	68	14	single	single	JJ
cord-280878-1kt51viz	68	15	TM	TM	NNP
cord-280878-1kt51viz	68	16	domain	domain	NN
cord-280878-1kt51viz	68	17	and	and	CC
cord-280878-1kt51viz	68	18	form	form	NN
cord-280878-1kt51viz	68	19	homotetramers	homotetramers	NNP
cord-280878-1kt51viz	68	20	Wang	Wang	NNP
cord-280878-1kt51viz	68	21	,	,	,
cord-280878-1kt51viz	68	22	Pielak	Pielak	NNP
cord-280878-1kt51viz	68	23	,	,	,
cord-280878-1kt51viz	68	24	McClintock	McClintock	NNP
cord-280878-1kt51viz	68	25	,	,	,
cord-280878-1kt51viz	68	26	&	&	CC
cord-280878-1kt51viz	68	27	Chou	Chou	NNP
cord-280878-1kt51viz	68	28	,	,	,
cord-280878-1kt51viz	68	29	2009	2009	CD
cord-280878-1kt51viz	68	30	)	)	-RRB-
cord-280878-1kt51viz	68	31	.	.	.
cord-280878-1kt51viz	69	1	In	in	IN
cord-280878-1kt51viz	69	2	comparison	comparison	NN
cord-280878-1kt51viz	69	3	,	,	,
cord-280878-1kt51viz	69	4	BM2	BM2	NNP
cord-280878-1kt51viz	69	5	is	be	VBZ
cord-280878-1kt51viz	69	6	completely	completely	RB
cord-280878-1kt51viz	69	7	insensitive	insensitive	JJ
cord-280878-1kt51viz	69	8	to	to	IN
cord-280878-1kt51viz	69	9	Amt	Amt	NNP
cord-280878-1kt51viz	69	10	or	or	CC
cord-280878-1kt51viz	69	11	Rim	Rim	NNP
cord-280878-1kt51viz	69	12	(	(	-LRB-
cord-280878-1kt51viz	69	13	Mould	Mould	NNP
cord-280878-1kt51viz	69	14	et	et	NNP
cord-280878-1kt51viz	69	15	al	al	NNP
cord-280878-1kt51viz	69	16	.	.	NNP
cord-280878-1kt51viz	69	17	,	,	,
cord-280878-1kt51viz	69	18	2003	2003	CD
cord-280878-1kt51viz	69	19	;	;	:
cord-280878-1kt51viz	69	20	Pinto	Pinto	NNP
cord-280878-1kt51viz	69	21	&	&	CC
cord-280878-1kt51viz	69	22	Lamb	Lamb	NNP
cord-280878-1kt51viz	69	23	,	,	,
cord-280878-1kt51viz	69	24	2006	2006	CD
cord-280878-1kt51viz	69	25	)	)	-RRB-
cord-280878-1kt51viz	69	26	and	and	CC
cord-280878-1kt51viz	69	27	no	no	DT
cord-280878-1kt51viz	69	28	BM2	BM2	NNP
cord-280878-1kt51viz	69	29	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	69	30	have	have	VBP
cord-280878-1kt51viz	69	31	been	be	VBN
cord-280878-1kt51viz	69	32	identified	identify	VBN
cord-280878-1kt51viz	69	33	yet	yet	RB
cord-280878-1kt51viz	69	34	.	.	.
cord-280878-1kt51viz	70	1	The	the	DT
cord-280878-1kt51viz	70	2	location	location	NN
cord-280878-1kt51viz	70	3	of	of	IN
cord-280878-1kt51viz	70	4	the	the	DT
cord-280878-1kt51viz	70	5	binding	binding	NN
cord-280878-1kt51viz	70	6	site	site	NN
cord-280878-1kt51viz	70	7	for	for	IN
cord-280878-1kt51viz	70	8	the	the	DT
cord-280878-1kt51viz	70	9	adamantanes	adamantanes	NNPS
cord-280878-1kt51viz	70	10	Amt	Amt	NNP
cord-280878-1kt51viz	70	11	and	and	CC
cord-280878-1kt51viz	70	12	Rim	Rim	NNP
cord-280878-1kt51viz	70	13	in	in	IN
cord-280878-1kt51viz	70	14	AM2	AM2	NNP
cord-280878-1kt51viz	70	15	was	be	VBD
cord-280878-1kt51viz	70	16	initially	initially	RB
cord-280878-1kt51viz	70	17	controversial	controversial	JJ
cord-280878-1kt51viz	70	18	.	.	.
cord-280878-1kt51viz	71	1	A	a	DT
cord-280878-1kt51viz	71	2	crystallographic	crystallographic	JJ
cord-280878-1kt51viz	71	3	structure	structure	NN
cord-280878-1kt51viz	71	4	suggested	suggest	VBD
cord-280878-1kt51viz	71	5	a	a	DT
cord-280878-1kt51viz	71	6	pore	pore	NN
cord-280878-1kt51viz	71	7	-	-	HYPH
cord-280878-1kt51viz	71	8	binding	bind	VBG
cord-280878-1kt51viz	71	9	model	model	NN
cord-280878-1kt51viz	71	10	in	in	IN
cord-280878-1kt51viz	71	11	the	the	DT
cord-280878-1kt51viz	71	12	amino	amino	NN
cord-280878-1kt51viz	71	13	-	-	HYPH
cord-280878-1kt51viz	71	14	terminal	terminal	NN
cord-280878-1kt51viz	71	15	part	part	NN
cord-280878-1kt51viz	71	16	of	of	IN
cord-280878-1kt51viz	71	17	the	the	DT
cord-280878-1kt51viz	71	18	TM	TM	NNP
cord-280878-1kt51viz	71	19	(	(	-LRB-
cord-280878-1kt51viz	71	20	22	22	CD
cord-280878-1kt51viz	71	21	-	-	SYM
cord-280878-1kt51viz	71	22	46	46	CD
cord-280878-1kt51viz	71	23	)	)	-RRB-
cord-280878-1kt51viz	71	24	,	,	,
cord-280878-1kt51viz	71	25	ie	ie	FW
cord-280878-1kt51viz	71	26	,	,	,
cord-280878-1kt51viz	71	27	the	the	DT
cord-280878-1kt51viz	71	28	P	p	NN
cord-280878-1kt51viz	71	29	-	-	HYPH
cord-280878-1kt51viz	71	30	binding	bind	VBG
cord-280878-1kt51viz	71	31	site	site	NN
cord-280878-1kt51viz	71	32	(	(	-LRB-
cord-280878-1kt51viz	71	33	Stouffer	Stouffer	NNP
cord-280878-1kt51viz	71	34	et	et	NNP
cord-280878-1kt51viz	71	35	al	al	NNP
cord-280878-1kt51viz	71	36	.	.	NNP
cord-280878-1kt51viz	71	37	,	,	,
cord-280878-1kt51viz	71	38	2008	2008	CD
cord-280878-1kt51viz	71	39	)	)	-RRB-
cord-280878-1kt51viz	72	1	(	(	-LRB-
cord-280878-1kt51viz	72	2	Fig	Fig	NNP
cord-280878-1kt51viz	72	3	.	.	.
cord-280878-1kt51viz	72	4	1A	1a	NN
cord-280878-1kt51viz	72	5	-C	-C	NNPS
cord-280878-1kt51viz	72	6	)	)	-RRB-
cord-280878-1kt51viz	72	7	.	.	.
cord-280878-1kt51viz	73	1	In	in	IN
cord-280878-1kt51viz	73	2	the	the	DT
cord-280878-1kt51viz	73	3	same	same	JJ
cord-280878-1kt51viz	73	4	and	and	CC
cord-280878-1kt51viz	73	5	in	in	IN
cord-280878-1kt51viz	73	6	the	the	DT
cord-280878-1kt51viz	73	7	following	following	JJ
cord-280878-1kt51viz	73	8	year	year	NN
cord-280878-1kt51viz	73	9	,	,	,
cord-280878-1kt51viz	73	10	a	a	DT
cord-280878-1kt51viz	73	11	solution	solution	NN
cord-280878-1kt51viz	73	12	NMR	nmr	NN
cord-280878-1kt51viz	73	13	-	-	HYPH
cord-280878-1kt51viz	73	14	based	base	VBN
cord-280878-1kt51viz	73	15	structure	structure	NN
cord-280878-1kt51viz	73	16	of	of	IN
cord-280878-1kt51viz	73	17	a	a	DT
cord-280878-1kt51viz	73	18	longer	long	JJR
cord-280878-1kt51viz	73	19	construct	construct	NN
cord-280878-1kt51viz	73	20	of	of	IN
cord-280878-1kt51viz	73	21	AM2	AM2	NNP
cord-280878-1kt51viz	73	22	(	(	-LRB-
cord-280878-1kt51viz	73	23	18	18	CD
cord-280878-1kt51viz	73	24	-	-	SYM
cord-280878-1kt51viz	73	25	60	60	CD
cord-280878-1kt51viz	73	26	)	)	-RRB-
cord-280878-1kt51viz	73	27	(	(	-LRB-
cord-280878-1kt51viz	73	28	Pielak	Pielak	NNP
cord-280878-1kt51viz	73	29	,	,	,
cord-280878-1kt51viz	73	30	Schnell	Schnell	NNP
cord-280878-1kt51viz	73	31	,	,	,
cord-280878-1kt51viz	73	32	&	&	CC
cord-280878-1kt51viz	73	33	Chou	Chou	NNP
cord-280878-1kt51viz	73	34	,	,	,
cord-280878-1kt51viz	73	35	2009	2009	CD
cord-280878-1kt51viz	73	36	;	;	:
cord-280878-1kt51viz	73	37	Schnell	Schnell	NNP
cord-280878-1kt51viz	73	38	&	&	CC
cord-280878-1kt51viz	73	39	Chou	Chou	NNP
cord-280878-1kt51viz	73	40	,	,	,
cord-280878-1kt51viz	73	41	2008	2008	CD
cord-280878-1kt51viz	73	42	)	)	-RRB-
cord-280878-1kt51viz	73	43	proposed	propose	VBD
cord-280878-1kt51viz	73	44	a	a	DT
cord-280878-1kt51viz	73	45	surface	surface	NN
cord-280878-1kt51viz	73	46	-	-	HYPH
cord-280878-1kt51viz	73	47	binding	bind	VBG
cord-280878-1kt51viz	73	48	site	site	NN
cord-280878-1kt51viz	73	49	(	(	-LRB-
cord-280878-1kt51viz	73	50	the	the	DT
cord-280878-1kt51viz	73	51	S	s	NN
cord-280878-1kt51viz	73	52	-	-	HYPH
cord-280878-1kt51viz	73	53	binding	bind	VBG
cord-280878-1kt51viz	73	54	site	site	NN
cord-280878-1kt51viz	73	55	)	)	-RRB-
cord-280878-1kt51viz	73	56	for	for	IN
cord-280878-1kt51viz	73	57	Rim	Rim	NNP
cord-280878-1kt51viz	73	58	,	,	,
cord-280878-1kt51viz	73	59	on	on	IN
cord-280878-1kt51viz	73	60	the	the	DT
cord-280878-1kt51viz	73	61	carboxy	carboxy	JJ
cord-280878-1kt51viz	73	62	-	-	HYPH
cord-280878-1kt51viz	73	63	terminal	terminal	NN
cord-280878-1kt51viz	73	64	,	,	,
cord-280878-1kt51viz	73	65	lipid	lipid	NN
cord-280878-1kt51viz	73	66	-	-	HYPH
cord-280878-1kt51viz	73	67	facing	face	VBG
cord-280878-1kt51viz	73	68	surface	surface	NN
cord-280878-1kt51viz	73	69	of	of	IN
cord-280878-1kt51viz	73	70	the	the	DT
cord-280878-1kt51viz	73	71	helices	helix	NNS
cord-280878-1kt51viz	73	72	(	(	-LRB-
cord-280878-1kt51viz	73	73	Fig	Fig	NNP
cord-280878-1kt51viz	73	74	.	.	.
cord-280878-1kt51viz	73	75	1D	1d	CD
cord-280878-1kt51viz	73	76	-	-	HYPH
cord-280878-1kt51viz	73	77	G	G	NNP
cord-280878-1kt51viz	73	78	)	)	-RRB-
cord-280878-1kt51viz	73	79	,	,	,
cord-280878-1kt51viz	73	80	suggesting	suggest	VBG
cord-280878-1kt51viz	73	81	an	an	DT
cord-280878-1kt51viz	73	82	alternative	alternative	JJ
cord-280878-1kt51viz	73	83	allosteric	allosteric	JJ
cord-280878-1kt51viz	73	84	mechanism	mechanism	NN
cord-280878-1kt51viz	73	85	of	of	IN
cord-280878-1kt51viz	73	86	inhibition	inhibition	NN
cord-280878-1kt51viz	73	87	.	.	.
cord-280878-1kt51viz	74	1	In	in	IN
cord-280878-1kt51viz	74	2	this	this	DT
cord-280878-1kt51viz	74	3	allosteric	allosteric	JJ
cord-280878-1kt51viz	74	4	binding	binding	NN
cord-280878-1kt51viz	74	5	site	site	NN
cord-280878-1kt51viz	74	6	,	,	,
cord-280878-1kt51viz	74	7	the	the	DT
cord-280878-1kt51viz	74	8	adamantane	adamantane	NNP
cord-280878-1kt51viz	74	9	group	group	NN
cord-280878-1kt51viz	74	10	interacted	interact	VBD
cord-280878-1kt51viz	74	11	favourably	favourably	RB
cord-280878-1kt51viz	74	12	with	with	IN
cord-280878-1kt51viz	74	13	the	the	DT
cord-280878-1kt51viz	74	14	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	74	15	side	side	NN
cord-280878-1kt51viz	74	16	chains	chain	NNS
cord-280878-1kt51viz	74	17	of	of	IN
cord-280878-1kt51viz	74	18	Leu-40	leu-40	NN
cord-280878-1kt51viz	74	19	,	,	,
cord-280878-1kt51viz	74	20	Leu-43	Leu-43	NNP
cord-280878-1kt51viz	74	21	,	,	,
cord-280878-1kt51viz	74	22	and	and	CC
cord-280878-1kt51viz	74	23	Ile-42	Ile-42	NNP
cord-280878-1kt51viz	74	24	,	,	,
cord-280878-1kt51viz	74	25	whereas	whereas	IN
cord-280878-1kt51viz	74	26	the	the	DT
cord-280878-1kt51viz	74	27	positively	positively	RB
cord-280878-1kt51viz	74	28	charged	charge	VBN
cord-280878-1kt51viz	74	29	ammonium	ammonium	NN
cord-280878-1kt51viz	74	30	group	group	NN
cord-280878-1kt51viz	74	31	interacted	interact	VBD
cord-280878-1kt51viz	74	32	with	with	IN
cord-280878-1kt51viz	74	33	the	the	DT
cord-280878-1kt51viz	74	34	polar	polar	JJ
cord-280878-1kt51viz	74	35	patch	patch	NN
cord-280878-1kt51viz	74	36	formed	form	VBN
cord-280878-1kt51viz	74	37	by	by	IN
cord-280878-1kt51viz	74	38	Figure	figure	NN
cord-280878-1kt51viz	74	39	1	1	CD
cord-280878-1kt51viz	74	40	P	p	NN
cord-280878-1kt51viz	74	41	-	-	,
cord-280878-1kt51viz	74	42	and	and	CC
cord-280878-1kt51viz	74	43	S	s	NN
cord-280878-1kt51viz	74	44	-	-	HYPH
cord-280878-1kt51viz	74	45	binding	bind	VBG
cord-280878-1kt51viz	74	46	sites	site	NNS
cord-280878-1kt51viz	74	47	for	for	IN
cord-280878-1kt51viz	74	48	Amt	Amt	NNP
cord-280878-1kt51viz	74	49	and	and	CC
cord-280878-1kt51viz	74	50	Rim	Rim	NNP
cord-280878-1kt51viz	74	51	to	to	IN
cord-280878-1kt51viz	74	52	IAV	IAV	NNP
cord-280878-1kt51viz	74	53	M2	M2	NNP
cord-280878-1kt51viz	74	54	.	.	.
cord-280878-1kt51viz	75	1	(	(	-LRB-
cord-280878-1kt51viz	75	2	A	A	NNP
cord-280878-1kt51viz	75	3	-	-	HYPH
cord-280878-1kt51viz	75	4	C	c	NN
cord-280878-1kt51viz	75	5	)	)	-RRB-
cord-280878-1kt51viz	76	1	AM2	AM2	NNP
cord-280878-1kt51viz	76	2	TM	TM	NNP
cord-280878-1kt51viz	76	3	domain	domain	NN
cord-280878-1kt51viz	76	4	crystallized	crystallize	VBN
cord-280878-1kt51viz	76	5	in	in	IN
cord-280878-1kt51viz	76	6	detergent	detergent	NN
cord-280878-1kt51viz	76	7	,	,	,
cord-280878-1kt51viz	76	8	with	with	IN
cord-280878-1kt51viz	76	9	the	the	DT
cord-280878-1kt51viz	76	10	most	most	RBS
cord-280878-1kt51viz	76	11	critical	critical	JJ
cord-280878-1kt51viz	76	12	residues	residue	NNS
cord-280878-1kt51viz	76	13	identified	identify	VBN
cord-280878-1kt51viz	76	14	by	by	IN
cord-280878-1kt51viz	76	15	site	site	NN
cord-280878-1kt51viz	76	16	-	-	HYPH
cord-280878-1kt51viz	76	17	directed	direct	VBN
cord-280878-1kt51viz	76	18	mutagenesis	mutagenesis	NN
cord-280878-1kt51viz	76	19	lining	line	VBG
cord-280878-1kt51viz	76	20	the	the	DT
cord-280878-1kt51viz	76	21	AM2	am2	JJ
cord-280878-1kt51viz	76	22	pore	pore	NN
cord-280878-1kt51viz	76	23	(	(	-LRB-
cord-280878-1kt51viz	76	24	A	a	NN
cord-280878-1kt51viz	76	25	)	)	-RRB-
cord-280878-1kt51viz	76	26	;	;	:
cord-280878-1kt51viz	76	27	omit	omit	VB
cord-280878-1kt51viz	76	28	map	map	NN
cord-280878-1kt51viz	76	29	showing	show	VBG
cord-280878-1kt51viz	76	30	electron	electron	NN
cord-280878-1kt51viz	76	31	density	density	NN
cord-280878-1kt51viz	76	32	in	in	IN
cord-280878-1kt51viz	76	33	the	the	DT
cord-280878-1kt51viz	76	34	Amt	Amt	NNP
cord-280878-1kt51viz	76	35	binding	bind	VBG
cord-280878-1kt51viz	76	36	region	region	NN
cord-280878-1kt51viz	76	37	(	(	-LRB-
cord-280878-1kt51viz	76	38	B	b	NN
cord-280878-1kt51viz	76	39	)	)	-RRB-
cord-280878-1kt51viz	76	40	;	;	:
cord-280878-1kt51viz	76	41	structure	structure	NN
cord-280878-1kt51viz	76	42	of	of	IN
cord-280878-1kt51viz	76	43	amantadine	amantadine	NNP
cord-280878-1kt51viz	76	44	(	(	-LRB-
cord-280878-1kt51viz	76	45	nitrogen	nitrogen	NN
cord-280878-1kt51viz	76	46	in	in	IN
cord-280878-1kt51viz	76	47	cyan	cyan	NNP
cord-280878-1kt51viz	76	48	(	(	-LRB-
cord-280878-1kt51viz	76	49	light	light	JJ
cord-280878-1kt51viz	76	50	gray	gray	NN
cord-280878-1kt51viz	76	51	in	in	IN
cord-280878-1kt51viz	76	52	the	the	DT
cord-280878-1kt51viz	76	53	print	print	NN
cord-280878-1kt51viz	76	54	version	version	NN
cord-280878-1kt51viz	76	55	)	)	-RRB-
cord-280878-1kt51viz	76	56	and	and	CC
cord-280878-1kt51viz	76	57	carbon	carbon	NN
cord-280878-1kt51viz	76	58	in	in	IN
cord-280878-1kt51viz	76	59	white	white	JJ
cord-280878-1kt51viz	76	60	)	)	-RRB-
cord-280878-1kt51viz	76	61	inside	inside	IN
cord-280878-1kt51viz	76	62	the	the	DT
cord-280878-1kt51viz	76	63	binding	binding	NN
cord-280878-1kt51viz	76	64	site	site	NN
cord-280878-1kt51viz	76	65	showing	show	VBG
cord-280878-1kt51viz	76	66	the	the	DT
cord-280878-1kt51viz	76	67	surface	surface	NN
cord-280878-1kt51viz	76	68	associated	associate	VBN
cord-280878-1kt51viz	76	69	with	with	IN
cord-280878-1kt51viz	76	70	residues	residue	NNS
cord-280878-1kt51viz	76	71	Val-27	Val-27	NNP
cord-280878-1kt51viz	76	72	(	(	-LRB-
cord-280878-1kt51viz	76	73	red	red	JJ
cord-280878-1kt51viz	76	74	(	(	-LRB-
cord-280878-1kt51viz	76	75	light	light	JJ
cord-280878-1kt51viz	76	76	gray	gray	NN
cord-280878-1kt51viz	76	77	in	in	IN
cord-280878-1kt51viz	76	78	the	the	DT
cord-280878-1kt51viz	76	79	print	print	NN
cord-280878-1kt51viz	76	80	version	version	NN
cord-280878-1kt51viz	76	81	)	)	-RRB-
cord-280878-1kt51viz	76	82	surface	surface	NN
cord-280878-1kt51viz	76	83	)	)	-RRB-
cord-280878-1kt51viz	76	84	,	,	,
cord-280878-1kt51viz	76	85	Ala-30	Ala-30	NNP
cord-280878-1kt51viz	76	86	(	(	-LRB-
cord-280878-1kt51viz	76	87	green	green	JJ
cord-280878-1kt51viz	76	88	(	(	-LRB-
cord-280878-1kt51viz	76	89	dark	dark	JJ
cord-280878-1kt51viz	76	90	gray	gray	NN
cord-280878-1kt51viz	76	91	in	in	IN
cord-280878-1kt51viz	76	92	the	the	DT
cord-280878-1kt51viz	76	93	print	print	NN
cord-280878-1kt51viz	76	94	version	version	NN
cord-280878-1kt51viz	76	95	)	)	-RRB-
cord-280878-1kt51viz	76	96	)	)	-RRB-
cord-280878-1kt51viz	76	97	,	,	,
cord-280878-1kt51viz	76	98	Ser-31	Ser-31	NNP
cord-280878-1kt51viz	76	99	(	(	-LRB-
cord-280878-1kt51viz	76	100	blue	blue	JJ
cord-280878-1kt51viz	76	101	(	(	-LRB-
cord-280878-1kt51viz	76	102	light	light	JJ
cord-280878-1kt51viz	76	103	gray	gray	NN
cord-280878-1kt51viz	76	104	in	in	IN
cord-280878-1kt51viz	76	105	the	the	DT
cord-280878-1kt51viz	76	106	print	print	NN
cord-280878-1kt51viz	76	107	version	version	NN
cord-280878-1kt51viz	76	108	)	)	-RRB-
cord-280878-1kt51viz	76	109	)	)	-RRB-
cord-280878-1kt51viz	76	110	,	,	,
cord-280878-1kt51viz	76	111	and	and	CC
cord-280878-1kt51viz	76	112	Gly-34	Gly-34	NNP
cord-280878-1kt51viz	76	113	(	(	-LRB-
cord-280878-1kt51viz	76	114	orange	orange	NNP
cord-280878-1kt51viz	76	115	(	(	-LRB-
cord-280878-1kt51viz	76	116	light	light	JJ
cord-280878-1kt51viz	76	117	gray	gray	NN
cord-280878-1kt51viz	76	118	in	in	IN
cord-280878-1kt51viz	76	119	the	the	DT
cord-280878-1kt51viz	76	120	print	print	NN
cord-280878-1kt51viz	76	121	version	version	NN
cord-280878-1kt51viz	76	122	)	)	-RRB-
cord-280878-1kt51viz	76	123	)	)	-RRB-
cord-280878-1kt51viz	76	124	(	(	-LRB-
cord-280878-1kt51viz	76	125	C	C	NNP
cord-280878-1kt51viz	76	126	)	)	-RRB-
cord-280878-1kt51viz	76	127	;	;	:
cord-280878-1kt51viz	76	128	(	(	-LRB-
cord-280878-1kt51viz	76	129	D	d	NN
cord-280878-1kt51viz	76	130	and	and	CC
cord-280878-1kt51viz	76	131	E	E	NNP
cord-280878-1kt51viz	76	132	)	)	-RRB-
cord-280878-1kt51viz	76	133	,	,	,
cord-280878-1kt51viz	76	134	an	an	DT
cord-280878-1kt51viz	76	135	ensemble	ensemble	NN
cord-280878-1kt51viz	76	136	of	of	IN
cord-280878-1kt51viz	76	137	15	15	CD
cord-280878-1kt51viz	76	138	low	low	JJ
cord-280878-1kt51viz	76	139	-	-	HYPH
cord-280878-1kt51viz	76	140	energy	energy	NN
cord-280878-1kt51viz	76	141	structures	structure	NNS
cord-280878-1kt51viz	76	142	derived	derive	VBN
cord-280878-1kt51viz	76	143	from	from	IN
cord-280878-1kt51viz	76	144	NMR	NMR	NNP
cord-280878-1kt51viz	76	145	restraints	restraint	NNS
cord-280878-1kt51viz	76	146	,	,	,
cord-280878-1kt51viz	76	147	with	with	IN
cord-280878-1kt51viz	76	148	TM	TM	NNP
cord-280878-1kt51viz	76	149	α	α	NNP
cord-280878-1kt51viz	76	150	-	-	HYPH
cord-280878-1kt51viz	76	151	helices	helices	NNP
cord-280878-1kt51viz	76	152	(	(	-LRB-
cord-280878-1kt51viz	76	153	residues	residue	NNS
cord-280878-1kt51viz	76	154	25	25	CD
cord-280878-1kt51viz	76	155	-	-	SYM
cord-280878-1kt51viz	76	156	46	46	CD
cord-280878-1kt51viz	76	157	)	)	-RRB-
cord-280878-1kt51viz	76	158	and	and	CC
cord-280878-1kt51viz	76	159	amphipathic	amphipathic	NNP
cord-280878-1kt51viz	76	160	helices	helix	NNS
cord-280878-1kt51viz	76	161	(	(	-LRB-
cord-280878-1kt51viz	76	162	residues	residue	NNS
cord-280878-1kt51viz	76	163	51	51	CD
cord-280878-1kt51viz	76	164	-	-	SYM
cord-280878-1kt51viz	76	165	59	59	CD
cord-280878-1kt51viz	76	166	)	)	-RRB-
cord-280878-1kt51viz	76	167	superimposed	superimpose	VBN
cord-280878-1kt51viz	76	168	separately	separately	RB
cord-280878-1kt51viz	76	169	(	(	-LRB-
cord-280878-1kt51viz	76	170	D	D	NNP
cord-280878-1kt51viz	76	171	)	)	-RRB-
cord-280878-1kt51viz	76	172	;	;	:
cord-280878-1kt51viz	76	173	ribbon	ribbon	NN
cord-280878-1kt51viz	76	174	representation	representation	NN
cord-280878-1kt51viz	76	175	,	,	,
cord-280878-1kt51viz	76	176	showing	show	VBG
cord-280878-1kt51viz	76	177	the	the	DT
cord-280878-1kt51viz	76	178	drug	drug	NN
cord-280878-1kt51viz	76	179	Rim	rim	NN
cord-280878-1kt51viz	76	180	(	(	-LRB-
cord-280878-1kt51viz	76	181	colored	color	VBN
cord-280878-1kt51viz	76	182	in	in	IN
cord-280878-1kt51viz	76	183	red	red	JJ
cord-280878-1kt51viz	76	184	(	(	-LRB-
cord-280878-1kt51viz	76	185	light	light	JJ
cord-280878-1kt51viz	76	186	gray	gray	NN
cord-280878-1kt51viz	76	187	in	in	IN
cord-280878-1kt51viz	76	188	the	the	DT
cord-280878-1kt51viz	76	189	print	print	NN
cord-280878-1kt51viz	76	190	version	version	NN
cord-280878-1kt51viz	76	191	)	)	-RRB-
cord-280878-1kt51viz	76	192	)	)	-RRB-
cord-280878-1kt51viz	77	1	(	(	-LRB-
cord-280878-1kt51viz	77	2	E	E	NNP
cord-280878-1kt51viz	77	3	)	)	-RRB-
cord-280878-1kt51viz	77	4	;	;	:
cord-280878-1kt51viz	77	5	(	(	-LRB-
cord-280878-1kt51viz	77	6	F	F	NNP
cord-280878-1kt51viz	77	7	and	and	CC
cord-280878-1kt51viz	77	8	G	G	NNP
cord-280878-1kt51viz	77	9	)	)	-RRB-
cord-280878-1kt51viz	77	10	,	,	,
cord-280878-1kt51viz	77	11	surface	surface	NN
cord-280878-1kt51viz	77	12	representation	representation	NN
cord-280878-1kt51viz	77	13	of	of	IN
cord-280878-1kt51viz	77	14	the	the	DT
cord-280878-1kt51viz	77	15	Rim	rim	NN
cord-280878-1kt51viz	77	16	-	-	HYPH
cord-280878-1kt51viz	77	17	binding	bind	VBG
cord-280878-1kt51viz	77	18	pocket	pocket	NN
cord-280878-1kt51viz	77	19	,	,	,
cord-280878-1kt51viz	77	20	showing	show	VBG
cord-280878-1kt51viz	77	21	the	the	DT
cord-280878-1kt51viz	77	22	Asp-44	Asp-44	NNP
cord-280878-1kt51viz	77	23	,	,	,
cord-280878-1kt51viz	77	24	the	the	DT
cord-280878-1kt51viz	77	25	indole	indole	NN
cord-280878-1kt51viz	77	26	amine	amine	NN
cord-280878-1kt51viz	77	27	of	of	IN
cord-280878-1kt51viz	77	28	Trp-41	Trp-41	NNP
cord-280878-1kt51viz	77	29	,	,	,
cord-280878-1kt51viz	77	30	and	and	CC
cord-280878-1kt51viz	77	31	Arg-45	Arg-45	NNP
cord-280878-1kt51viz	77	32	,	,	,
cord-280878-1kt51viz	77	33	which	which	WDT
cord-280878-1kt51viz	77	34	form	form	VBP
cord-280878-1kt51viz	77	35	the	the	DT
cord-280878-1kt51viz	77	36	polar	polar	JJ
cord-280878-1kt51viz	77	37	patch	patch	NN
cord-280878-1kt51viz	77	38	,	,	,
cord-280878-1kt51viz	77	39	as	as	RB
cord-280878-1kt51viz	77	40	well	well	RB
cord-280878-1kt51viz	77	41	as	as	IN
cord-280878-1kt51viz	77	42	the	the	DT
cord-280878-1kt51viz	77	43	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	77	44	wall	wall	NN
cord-280878-1kt51viz	77	45	composed	compose	VBN
cord-280878-1kt51viz	77	46	of	of	IN
cord-280878-1kt51viz	77	47	solution	solution	NN
cord-280878-1kt51viz	77	48	NMR	NMR	NNP
cord-280878-1kt51viz	77	49	structures	structure	NNS
cord-280878-1kt51viz	77	50	of	of	IN
cord-280878-1kt51viz	77	51	the	the	DT
cord-280878-1kt51viz	77	52	(	(	-LRB-
cord-280878-1kt51viz	77	53	AM2-BM2)TM	AM2-BM2)TM	NNP
cord-280878-1kt51viz	77	54	channel	channel	NN
cord-280878-1kt51viz	77	55	in	in	IN
cord-280878-1kt51viz	77	56	the	the	DT
cord-280878-1kt51viz	77	57	absence	absence	NN
cord-280878-1kt51viz	77	58	and	and	CC
cord-280878-1kt51viz	77	59	presence	presence	NN
cord-280878-1kt51viz	77	60	of	of	IN
cord-280878-1kt51viz	77	61	Rim	rim	NN
cord-280878-1kt51viz	77	62	;	;	,
cord-280878-1kt51viz	77	63	ensembles	ensemble	NNS
cord-280878-1kt51viz	77	64	of	of	IN
cord-280878-1kt51viz	77	65	15	15	CD
cord-280878-1kt51viz	77	66	low	low	JJ
cord-280878-1kt51viz	77	67	-	-	HYPH
cord-280878-1kt51viz	77	68	energy	energy	NN
cord-280878-1kt51viz	77	69	structures	structure	NNS
cord-280878-1kt51viz	77	70	of	of	IN
cord-280878-1kt51viz	77	71	drugbound	drugbound	NN
cord-280878-1kt51viz	77	72	chimera	chimera	NN
cord-280878-1kt51viz	77	73	channels	channel	NNS
cord-280878-1kt51viz	77	74	.	.	.
cord-280878-1kt51viz	78	1	Rim	rim	NN
cord-280878-1kt51viz	78	2	is	be	VBZ
cord-280878-1kt51viz	78	3	highlighted	highlight	VBN
cord-280878-1kt51viz	78	4	in	in	IN
cord-280878-1kt51viz	78	5	red	red	JJ
cord-280878-1kt51viz	78	6	(	(	-LRB-
cord-280878-1kt51viz	78	7	light	light	JJ
cord-280878-1kt51viz	78	8	gray	gray	NN
cord-280878-1kt51viz	78	9	in	in	IN
cord-280878-1kt51viz	78	10	the	the	DT
cord-280878-1kt51viz	78	11	print	print	NN
cord-280878-1kt51viz	78	12	version	version	NN
cord-280878-1kt51viz	78	13	)	)	-RRB-
cord-280878-1kt51viz	78	14	(	(	-LRB-
cord-280878-1kt51viz	78	15	H	h	NN
cord-280878-1kt51viz	78	16	)	)	-RRB-
cord-280878-1kt51viz	78	17	;	;	:
cord-280878-1kt51viz	78	18	ribbon	ribbon	NN
cord-280878-1kt51viz	78	19	representation	representation	NN
cord-280878-1kt51viz	78	20	of	of	IN
cord-280878-1kt51viz	78	21	drug	drug	NN
cord-280878-1kt51viz	78	22	-	-	HYPH
cord-280878-1kt51viz	78	23	free	free	JJ
cord-280878-1kt51viz	78	24	(	(	-LRB-
cord-280878-1kt51viz	78	25	AM2-BM2)TM	AM2-BM2)TM	NNP
cord-280878-1kt51viz	78	26	tetramer	tetramer	NN
cord-280878-1kt51viz	78	27	(	(	-LRB-
cord-280878-1kt51viz	78	28	left	left	RB
cord-280878-1kt51viz	78	29	)	)	-RRB-
cord-280878-1kt51viz	78	30	,	,	,
cord-280878-1kt51viz	78	31	and	and	CC
cord-280878-1kt51viz	78	32	overlay	overlay	NN
cord-280878-1kt51viz	78	33	of	of	IN
cord-280878-1kt51viz	78	34	its	-PRON-	PRP$
cord-280878-1kt51viz	78	35	AM2	AM2	NNP
cord-280878-1kt51viz	78	36	and	and	CC
cord-280878-1kt51viz	78	37	BM2	BM2	NNP
cord-280878-1kt51viz	78	38	regions	region	NNS
cord-280878-1kt51viz	78	39	(	(	-LRB-
cord-280878-1kt51viz	78	40	green	green	JJ
cord-280878-1kt51viz	78	41	(	(	-LRB-
cord-280878-1kt51viz	78	42	dark	dark	JJ
cord-280878-1kt51viz	78	43	gray	gray	NN
cord-280878-1kt51viz	78	44	in	in	IN
cord-280878-1kt51viz	78	45	the	the	DT
cord-280878-1kt51viz	78	46	print	print	NN
cord-280878-1kt51viz	78	47	version	version	NN
cord-280878-1kt51viz	78	48	)	)	-RRB-
cord-280878-1kt51viz	78	49	)	)	-RRB-
cord-280878-1kt51viz	78	50	with	with	IN
cord-280878-1kt51viz	78	51	the	the	DT
cord-280878-1kt51viz	78	52	corresponding	correspond	VBG
cord-280878-1kt51viz	78	53	regions	region	NNS
cord-280878-1kt51viz	78	54	(	(	-LRB-
cord-280878-1kt51viz	78	55	yellow	yellow	JJ
cord-280878-1kt51viz	78	56	(	(	-LRB-
cord-280878-1kt51viz	78	57	light	light	JJ
cord-280878-1kt51viz	78	58	gray	gray	NN
cord-280878-1kt51viz	78	59	in	in	IN
cord-280878-1kt51viz	78	60	the	the	DT
cord-280878-1kt51viz	78	61	print	print	NN
cord-280878-1kt51viz	78	62	version	version	NN
cord-280878-1kt51viz	78	63	)	)	-RRB-
cord-280878-1kt51viz	78	64	)	)	-RRB-
cord-280878-1kt51viz	78	65	of	of	IN
cord-280878-1kt51viz	78	66	the	the	DT
cord-280878-1kt51viz	78	67	AM2	AM2	NNP
cord-280878-1kt51viz	78	68	(	(	-LRB-
cord-280878-1kt51viz	78	69	PDB	PDB	NNP
cord-280878-1kt51viz	78	70	code	code	NN
cord-280878-1kt51viz	78	71	:	:	:
cord-280878-1kt51viz	78	72	2RLF	2rlf	LS
cord-280878-1kt51viz	78	73	)	)	-RRB-
cord-280878-1kt51viz	78	74	and	and	CC
cord-280878-1kt51viz	78	75	BM2	BM2	NNP
cord-280878-1kt51viz	78	76	(	(	-LRB-
cord-280878-1kt51viz	78	77	PDB	PDB	NNP
cord-280878-1kt51viz	78	78	code	code	NN
cord-280878-1kt51viz	78	79	:	:	:
cord-280878-1kt51viz	79	1	2KIX	2kix	LS
cord-280878-1kt51viz	79	2	)	)	-RRB-
cord-280878-1kt51viz	79	3	structures	structure	NNS
cord-280878-1kt51viz	79	4	(	(	-LRB-
cord-280878-1kt51viz	79	5	right	right	RB
cord-280878-1kt51viz	79	6	)	)	-RRB-
cord-280878-1kt51viz	79	7	(	(	-LRB-
cord-280878-1kt51viz	79	8	I	i	NN
cord-280878-1kt51viz	79	9	)	)	-RRB-
cord-280878-1kt51viz	79	10	;	;	:
cord-280878-1kt51viz	79	11	overlay	overlay	NN
cord-280878-1kt51viz	79	12	of	of	IN
cord-280878-1kt51viz	79	13	the	the	DT
cord-280878-1kt51viz	79	14	drug	drug	NN
cord-280878-1kt51viz	79	15	-	-	HYPH
cord-280878-1kt51viz	79	16	free	free	JJ
cord-280878-1kt51viz	79	17	(	(	-LRB-
cord-280878-1kt51viz	79	18	white	white	JJ
cord-280878-1kt51viz	79	19	)	)	-RRB-
cord-280878-1kt51viz	79	20	and	and	CC
cord-280878-1kt51viz	79	21	the	the	DT
cord-280878-1kt51viz	79	22	drugbound	drugbound	NNP
cord-280878-1kt51viz	79	23	(	(	-LRB-
cord-280878-1kt51viz	79	24	cyan	cyan	NNP
cord-280878-1kt51viz	79	25	(	(	-LRB-
cord-280878-1kt51viz	79	26	light	light	JJ
cord-280878-1kt51viz	79	27	gray	gray	NN
cord-280878-1kt51viz	79	28	in	in	IN
cord-280878-1kt51viz	79	29	the	the	DT
cord-280878-1kt51viz	79	30	print	print	NN
cord-280878-1kt51viz	79	31	version	version	NN
cord-280878-1kt51viz	79	32	)	)	-RRB-
cord-280878-1kt51viz	79	33	)	)	-RRB-
cord-280878-1kt51viz	80	1	chimera	chimera	NN
cord-280878-1kt51viz	80	2	structures	structure	NNS
cord-280878-1kt51viz	80	3	,	,	,
cord-280878-1kt51viz	80	4	showing	show	VBG
cord-280878-1kt51viz	80	5	substantial	substantial	JJ
cord-280878-1kt51viz	80	6	differences	difference	NNS
cord-280878-1kt51viz	80	7	in	in	IN
cord-280878-1kt51viz	80	8	helical	helical	JJ
cord-280878-1kt51viz	80	9	packing	packing	NN
cord-280878-1kt51viz	80	10	(	(	-LRB-
cord-280878-1kt51viz	80	11	J	J	NNP
cord-280878-1kt51viz	80	12	)	)	-RRB-
cord-280878-1kt51viz	80	13	.	.	.
cord-280878-1kt51viz	81	1	Adapted	adapt	VBN
cord-280878-1kt51viz	81	2	by	by	IN
cord-280878-1kt51viz	81	3	permission	permission	NN
cord-280878-1kt51viz	81	4	from	from	IN
cord-280878-1kt51viz	81	5	Macmillan	Macmillan	NNP
cord-280878-1kt51viz	81	6	Publishers	Publishers	NNPS
cord-280878-1kt51viz	81	7	Ltd.	Ltd.	NNP
cord-280878-1kt51viz	81	8	:	:	:
cord-280878-1kt51viz	81	9	Stouffer	Stouffer	NNP
cord-280878-1kt51viz	81	10	,	,	,
cord-280878-1kt51viz	81	11	A.	A.	NNP
cord-280878-1kt51viz	81	12	L.	L.	NNP
cord-280878-1kt51viz	81	13	,	,	,
cord-280878-1kt51viz	81	14	Acharya	Acharya	NNP
cord-280878-1kt51viz	81	15	,	,	,
cord-280878-1kt51viz	81	16	R.	R.	NNP
cord-280878-1kt51viz	81	17	,	,	,
cord-280878-1kt51viz	81	18	Salom	Salom	NNP
cord-280878-1kt51viz	81	19	,	,	,
cord-280878-1kt51viz	81	20	D.	D.	NNP
cord-280878-1kt51viz	81	21	,	,	,
cord-280878-1kt51viz	81	22	Levine	Levine	NNP
cord-280878-1kt51viz	81	23	,	,	,
cord-280878-1kt51viz	81	24	A.	A.	NNP
cord-280878-1kt51viz	81	25	S.	S.	NNP
cord-280878-1kt51viz	81	26	,	,	,
cord-280878-1kt51viz	81	27	Di	Di	NNP
cord-280878-1kt51viz	81	28	Costanzo	Costanzo	NNP
cord-280878-1kt51viz	81	29	,	,	,
cord-280878-1kt51viz	81	30	L.	L.	NNP
cord-280878-1kt51viz	81	31	,	,	,
cord-280878-1kt51viz	81	32	Soto	Soto	NNP
cord-280878-1kt51viz	81	33	,	,	,
cord-280878-1kt51viz	81	34	C.	C.	NNP
cord-280878-1kt51viz	81	35	S.	S.	NNP
cord-280878-1kt51viz	81	36	,	,	,
cord-280878-1kt51viz	81	37	et	et	NNP
cord-280878-1kt51viz	81	38	al	al	NNP
cord-280878-1kt51viz	81	39	.	.	.
cord-280878-1kt51viz	82	1	(	(	-LRB-
cord-280878-1kt51viz	82	2	2008	2008	CD
cord-280878-1kt51viz	82	3	)	)	-RRB-
cord-280878-1kt51viz	82	4	.	.	.
cord-280878-1kt51viz	83	1	Asp-44	Asp-44	NNP
cord-280878-1kt51viz	83	2	and	and	CC
cord-280878-1kt51viz	83	3	Arg-45	Arg-45	NNP
cord-280878-1kt51viz	83	4	from	from	IN
cord-280878-1kt51viz	83	5	the	the	DT
cord-280878-1kt51viz	83	6	adjacent	adjacent	JJ
cord-280878-1kt51viz	83	7	subunit	subunit	NN
cord-280878-1kt51viz	83	8	(	(	-LRB-
cord-280878-1kt51viz	83	9	Fig	Fig	NNP
cord-280878-1kt51viz	83	10	.	.	.
cord-280878-1kt51viz	83	11	1	1	CD
cord-280878-1kt51viz	83	12	G	g	NN
cord-280878-1kt51viz	83	13	)	)	-RRB-
cord-280878-1kt51viz	83	14	.	.	.
cord-280878-1kt51viz	84	1	A	a	DT
cord-280878-1kt51viz	84	2	dilemmatic	dilemmatic	JJ
cord-280878-1kt51viz	84	3	feature	feature	NN
cord-280878-1kt51viz	84	4	of	of	IN
cord-280878-1kt51viz	84	5	allosteric	allosteric	JJ
cord-280878-1kt51viz	84	6	sites	site	NNS
cord-280878-1kt51viz	84	7	is	be	VBZ
cord-280878-1kt51viz	84	8	that	that	IN
cord-280878-1kt51viz	84	9	viral	viral	JJ
cord-280878-1kt51viz	84	10	mutations	mutation	NNS
cord-280878-1kt51viz	84	11	at	at	IN
cord-280878-1kt51viz	84	12	these	these	DT
cord-280878-1kt51viz	84	13	sites	site	NNS
cord-280878-1kt51viz	84	14	are	be	VBP
cord-280878-1kt51viz	84	15	easily	easily	RB
cord-280878-1kt51viz	84	16	accommodated	accommodate	VBN
cord-280878-1kt51viz	84	17	by	by	IN
cord-280878-1kt51viz	84	18	viruses	virus	NNS
cord-280878-1kt51viz	84	19	without	without	IN
cord-280878-1kt51viz	84	20	dramatic	dramatic	JJ
cord-280878-1kt51viz	84	21	loss	loss	NN
cord-280878-1kt51viz	84	22	of	of	IN
cord-280878-1kt51viz	84	23	fitness	fitness	NN
cord-280878-1kt51viz	84	24	.	.	.
cord-280878-1kt51viz	85	1	In	in	IN
cord-280878-1kt51viz	85	2	HCV	HCV	NNP
cord-280878-1kt51viz	85	3	,	,	,
cord-280878-1kt51viz	85	4	for	for	IN
cord-280878-1kt51viz	85	5	example	example	NN
cord-280878-1kt51viz	85	6	,	,	,
cord-280878-1kt51viz	85	7	protease	protease	NN
cord-280878-1kt51viz	85	8	inhibitor	inhibitor	NN
cord-280878-1kt51viz	85	9	monotherapy	monotherapy	NN
cord-280878-1kt51viz	85	10	can	can	MD
cord-280878-1kt51viz	85	11	rapidly	rapidly	RB
cord-280878-1kt51viz	85	12	select	select	VB
cord-280878-1kt51viz	85	13	resistant	resistant	JJ
cord-280878-1kt51viz	85	14	viral	viral	JJ
cord-280878-1kt51viz	85	15	populations	population	NNS
cord-280878-1kt51viz	85	16	within	within	IN
cord-280878-1kt51viz	85	17	a	a	DT
cord-280878-1kt51viz	85	18	few	few	JJ
cord-280878-1kt51viz	85	19	days	day	NNS
cord-280878-1kt51viz	85	20	(	(	-LRB-
cord-280878-1kt51viz	85	21	Schmidt	Schmidt	NNP
cord-280878-1kt51viz	85	22	et	et	NNP
cord-280878-1kt51viz	85	23	al	al	NNP
cord-280878-1kt51viz	85	24	.	.	NNP
cord-280878-1kt51viz	85	25	,	,	,
cord-280878-1kt51viz	85	26	2014	2014	CD
cord-280878-1kt51viz	85	27	)	)	-RRB-
cord-280878-1kt51viz	85	28	.	.	.
cord-280878-1kt51viz	86	1	However	however	RB
cord-280878-1kt51viz	86	2	,	,	,
cord-280878-1kt51viz	86	3	clear	clear	JJ
cord-280878-1kt51viz	86	4	support	support	NN
cord-280878-1kt51viz	86	5	for	for	IN
cord-280878-1kt51viz	86	6	the	the	DT
cord-280878-1kt51viz	86	7	P	p	NN
cord-280878-1kt51viz	86	8	-	-	HYPH
cord-280878-1kt51viz	86	9	binding	bind	VBG
cord-280878-1kt51viz	86	10	site	site	NN
cord-280878-1kt51viz	86	11	was	be	VBD
cord-280878-1kt51viz	86	12	obtained	obtain	VBN
cord-280878-1kt51viz	86	13	from	from	IN
cord-280878-1kt51viz	86	14	solidstate	solidstate	JJ
cord-280878-1kt51viz	86	15	NMR	NMR	NNP
cord-280878-1kt51viz	86	16	in	in	IN
cord-280878-1kt51viz	86	17	lipid	lipid	NN
cord-280878-1kt51viz	86	18	bilayers	bilayer	NNS
cord-280878-1kt51viz	86	19	(	(	-LRB-
cord-280878-1kt51viz	86	20	PDB	PDB	NNP
cord-280878-1kt51viz	86	21	ID	ID	NNP
cord-280878-1kt51viz	86	22	:	:	:
cord-280878-1kt51viz	86	23	2KQT	2kqt	LS
cord-280878-1kt51viz	86	24	)	)	-RRB-
cord-280878-1kt51viz	87	1	(	(	-LRB-
cord-280878-1kt51viz	87	2	Cady	Cady	NNP
cord-280878-1kt51viz	87	3	et	et	NNP
cord-280878-1kt51viz	87	4	al	al	NNP
cord-280878-1kt51viz	87	5	.	.	NNP
cord-280878-1kt51viz	87	6	,	,	,
cord-280878-1kt51viz	87	7	2010	2010	CD
cord-280878-1kt51viz	87	8	)	)	-RRB-
cord-280878-1kt51viz	87	9	;	;	:
cord-280878-1kt51viz	87	10	the	the	DT
cord-280878-1kt51viz	87	11	inhibitor	inhibitor	NN
cord-280878-1kt51viz	87	12	was	be	VBD
cord-280878-1kt51viz	87	13	found	find	VBN
cord-280878-1kt51viz	87	14	in	in	IN
cord-280878-1kt51viz	87	15	a	a	DT
cord-280878-1kt51viz	87	16	hydrophilic	hydrophilic	JJ
cord-280878-1kt51viz	87	17	pocket	pocket	NN
cord-280878-1kt51viz	87	18	formed	form	VBN
cord-280878-1kt51viz	87	19	by	by	IN
cord-280878-1kt51viz	87	20	Ala-30	Ala-30	NNP
cord-280878-1kt51viz	87	21	,	,	,
cord-280878-1kt51viz	87	22	Ser-31	Ser-31	NNP
cord-280878-1kt51viz	87	23	,	,	,
cord-280878-1kt51viz	87	24	and	and	CC
cord-280878-1kt51viz	87	25	Gly-34	Gly-34	NNP
cord-280878-1kt51viz	87	26	,	,	,
cord-280878-1kt51viz	87	27	ie	ie	NNP
cord-280878-1kt51viz	87	28	,	,	,
cord-280878-1kt51viz	87	29	occluding	occlude	VBG
cord-280878-1kt51viz	87	30	the	the	DT
cord-280878-1kt51viz	87	31	AM2	am2	JJ
cord-280878-1kt51viz	87	32	channel	channel	NN
cord-280878-1kt51viz	87	33	.	.	.
cord-280878-1kt51viz	88	1	In	in	IN
cord-280878-1kt51viz	88	2	this	this	DT
cord-280878-1kt51viz	88	3	case	case	NN
cord-280878-1kt51viz	88	4	,	,	,
cord-280878-1kt51viz	88	5	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	88	6	interactions	interaction	NNS
cord-280878-1kt51viz	88	7	were	be	VBD
cord-280878-1kt51viz	88	8	detected	detect	VBN
cord-280878-1kt51viz	88	9	between	between	IN
cord-280878-1kt51viz	88	10	the	the	DT
cord-280878-1kt51viz	88	11	adamantane	adamantane	NNP
cord-280878-1kt51viz	88	12	group	group	NN
cord-280878-1kt51viz	88	13	and	and	CC
cord-280878-1kt51viz	88	14	Val-27	Val-27	NNP
cord-280878-1kt51viz	88	15	side	side	NN
cord-280878-1kt51viz	88	16	chains	chain	NNS
cord-280878-1kt51viz	88	17	,	,	,
cord-280878-1kt51viz	88	18	whereas	whereas	IN
cord-280878-1kt51viz	88	19	the	the	DT
cord-280878-1kt51viz	88	20	ammonium	ammonium	NN
cord-280878-1kt51viz	88	21	group	group	NN
cord-280878-1kt51viz	88	22	was	be	VBD
cord-280878-1kt51viz	88	23	hydrogen	hydrogen	NN
cord-280878-1kt51viz	88	24	-	-	HYPH
cord-280878-1kt51viz	88	25	bonded	bond	VBN
cord-280878-1kt51viz	88	26	to	to	IN
cord-280878-1kt51viz	88	27	pore	pore	NN
cord-280878-1kt51viz	88	28	-	-	HYPH
cord-280878-1kt51viz	88	29	facing	face	VBG
cord-280878-1kt51viz	88	30	residues	residue	NNS
cord-280878-1kt51viz	88	31	and	and	CC
cord-280878-1kt51viz	88	32	water	water	NN
cord-280878-1kt51viz	88	33	molecules	molecule	NNS
cord-280878-1kt51viz	88	34	.	.	.
cord-280878-1kt51viz	89	1	The	the	DT
cord-280878-1kt51viz	89	2	latter	latter	JJ
cord-280878-1kt51viz	89	3	work	work	NN
cord-280878-1kt51viz	89	4	revealed	reveal	VBD
cord-280878-1kt51viz	89	5	that	that	IN
cord-280878-1kt51viz	89	6	the	the	DT
cord-280878-1kt51viz	89	7	S	S	NNP
cord-280878-1kt51viz	89	8	-	-	HYPH
cord-280878-1kt51viz	89	9	binding	bind	VBG
cord-280878-1kt51viz	89	10	site	site	NN
cord-280878-1kt51viz	89	11	was	be	VBD
cord-280878-1kt51viz	89	12	in	in	IN
cord-280878-1kt51viz	89	13	fact	fact	NN
cord-280878-1kt51viz	89	14	just	just	RB
cord-280878-1kt51viz	89	15	a	a	DT
cord-280878-1kt51viz	89	16	low	low	JJ
cord-280878-1kt51viz	89	17	-	-	HYPH
cord-280878-1kt51viz	89	18	affinity	affinity	NN
cord-280878-1kt51viz	89	19	site	site	NN
cord-280878-1kt51viz	89	20	,	,	,
cord-280878-1kt51viz	89	21	and	and	CC
cord-280878-1kt51viz	89	22	only	only	RB
cord-280878-1kt51viz	89	23	observed	observe	VBD
cord-280878-1kt51viz	89	24	at	at	IN
cord-280878-1kt51viz	89	25	high	high	JJ
cord-280878-1kt51viz	89	26	concentrations	concentration	NNS
cord-280878-1kt51viz	89	27	of	of	IN
cord-280878-1kt51viz	89	28	the	the	DT
cord-280878-1kt51viz	89	29	drug	drug	NN
cord-280878-1kt51viz	89	30	in	in	IN
cord-280878-1kt51viz	89	31	the	the	DT
cord-280878-1kt51viz	89	32	membrane	membrane	NN
cord-280878-1kt51viz	89	33	.	.	.
cord-280878-1kt51viz	90	1	Importantly	importantly	RB
cord-280878-1kt51viz	90	2	,	,	,
cord-280878-1kt51viz	90	3	Amt	Amt	NNP
cord-280878-1kt51viz	90	4	was	be	VBD
cord-280878-1kt51viz	90	5	found	find	VBN
cord-280878-1kt51viz	90	6	to	to	TO
cord-280878-1kt51viz	90	7	undergo	undergo	VB
cord-280878-1kt51viz	90	8	significant	significant	JJ
cord-280878-1kt51viz	90	9	motion	motion	NN
cord-280878-1kt51viz	90	10	in	in	IN
cord-280878-1kt51viz	90	11	the	the	DT
cord-280878-1kt51viz	90	12	N	n	CD
cord-280878-1kt51viz	90	13	-	-	HYPH
cord-280878-1kt51viz	90	14	terminal	terminal	JJ
cord-280878-1kt51viz	90	15	lumen	lumen	NN
cord-280878-1kt51viz	90	16	,	,	,
cord-280878-1kt51viz	90	17	suggesting	suggest	VBG
cord-280878-1kt51viz	90	18	that	that	IN
cord-280878-1kt51viz	90	19	its	-PRON-	PRP$
cord-280878-1kt51viz	90	20	structure	structure	NN
cord-280878-1kt51viz	90	21	can	can	MD
cord-280878-1kt51viz	90	22	be	be	VB
cord-280878-1kt51viz	90	23	improved	improve	VBN
cord-280878-1kt51viz	90	24	for	for	IN
cord-280878-1kt51viz	90	25	a	a	DT
cord-280878-1kt51viz	90	26	better	well	JJR
cord-280878-1kt51viz	90	27	fit	fit	NN
cord-280878-1kt51viz	90	28	to	to	IN
cord-280878-1kt51viz	90	29	the	the	DT
cord-280878-1kt51viz	90	30	AM2	am2	JJ
cord-280878-1kt51viz	90	31	channel	channel	NN
cord-280878-1kt51viz	90	32	.	.	.
cord-280878-1kt51viz	91	1	This	this	DT
cord-280878-1kt51viz	91	2	pore	pore	NN
cord-280878-1kt51viz	91	3	-	-	HYPH
cord-280878-1kt51viz	91	4	location	location	NN
cord-280878-1kt51viz	91	5	(	(	-LRB-
cord-280878-1kt51viz	91	6	P	p	NN
cord-280878-1kt51viz	91	7	-	-	HYPH
cord-280878-1kt51viz	91	8	binding	binding	NN
cord-280878-1kt51viz	91	9	)	)	-RRB-
cord-280878-1kt51viz	91	10	was	be	VBD
cord-280878-1kt51viz	91	11	also	also	RB
cord-280878-1kt51viz	91	12	further	further	RB
cord-280878-1kt51viz	91	13	validated	validate	VBN
cord-280878-1kt51viz	91	14	by	by	IN
cord-280878-1kt51viz	91	15	Chou	Chou	NNP
cord-280878-1kt51viz	91	16	et	et	NNP
cord-280878-1kt51viz	91	17	al	al	NNP
cord-280878-1kt51viz	91	18	.	.	.
cord-280878-1kt51viz	92	1	by	by	IN
cord-280878-1kt51viz	92	2	solution	solution	NN
cord-280878-1kt51viz	92	3	NMR	NMR	NNP
cord-280878-1kt51viz	92	4	(	(	-LRB-
cord-280878-1kt51viz	92	5	Pielak	Pielak	NNP
cord-280878-1kt51viz	92	6	,	,	,
cord-280878-1kt51viz	92	7	Oxenoid	Oxenoid	NNP
cord-280878-1kt51viz	92	8	,	,	,
cord-280878-1kt51viz	92	9	&	&	CC
cord-280878-1kt51viz	92	10	Chou	Chou	NNP
cord-280878-1kt51viz	92	11	,	,	,
cord-280878-1kt51viz	92	12	2011	2011	CD
cord-280878-1kt51viz	92	13	)	)	-RRB-
cord-280878-1kt51viz	92	14	using	use	VBG
cord-280878-1kt51viz	92	15	an	an	DT
cord-280878-1kt51viz	92	16	M2	M2	NNP
cord-280878-1kt51viz	92	17	chimeric	chimeric	JJ
cord-280878-1kt51viz	92	18	sample	sample	NN
cord-280878-1kt51viz	92	19	,	,	,
cord-280878-1kt51viz	92	20	where	where	WRB
cord-280878-1kt51viz	92	21	the	the	DT
cord-280878-1kt51viz	92	22	N	n	CD
cord-280878-1kt51viz	92	23	-	-	HYPH
cord-280878-1kt51viz	92	24	terminal	terminal	JJ
cord-280878-1kt51viz	92	25	part	part	NN
cord-280878-1kt51viz	92	26	of	of	IN
cord-280878-1kt51viz	92	27	the	the	DT
cord-280878-1kt51viz	92	28	M2	M2	NNP
cord-280878-1kt51viz	92	29	TM	TM	NNP
cord-280878-1kt51viz	92	30	domain	domain	NN
cord-280878-1kt51viz	92	31	corresponded	correspond	VBD
cord-280878-1kt51viz	92	32	to	to	IN
cord-280878-1kt51viz	92	33	that	that	DT
cord-280878-1kt51viz	92	34	of	of	IN
cord-280878-1kt51viz	92	35	the	the	DT
cord-280878-1kt51viz	92	36	AM2	AM2	NNP
cord-280878-1kt51viz	92	37	,	,	,
cord-280878-1kt51viz	92	38	whereas	whereas	IN
cord-280878-1kt51viz	92	39	the	the	DT
cord-280878-1kt51viz	92	40	C	C	NNP
cord-280878-1kt51viz	92	41	-	-	HYPH
cord-280878-1kt51viz	92	42	terminal	terminal	NN
cord-280878-1kt51viz	92	43	part	part	NN
cord-280878-1kt51viz	92	44	was	be	VBD
cord-280878-1kt51viz	92	45	from	from	IN
cord-280878-1kt51viz	92	46	the	the	DT
cord-280878-1kt51viz	92	47	Amt	Amt	NNP
cord-280878-1kt51viz	92	48	-	-	HYPH
cord-280878-1kt51viz	92	49	insensitive	insensitive	JJ
cord-280878-1kt51viz	92	50	BM2	BM2	NNP
cord-280878-1kt51viz	92	51	(	(	-LRB-
cord-280878-1kt51viz	92	52	Fig	Fig	NNP
cord-280878-1kt51viz	92	53	.	.	.
cord-280878-1kt51viz	93	1	1H	1h	LS
cord-280878-1kt51viz	93	2	-J	-j	ADD
cord-280878-1kt51viz	93	3	)	)	-RRB-
cord-280878-1kt51viz	93	4	.	.	.
cord-280878-1kt51viz	94	1	In	in	IN
cord-280878-1kt51viz	94	2	that	that	DT
cord-280878-1kt51viz	94	3	model	model	NN
cord-280878-1kt51viz	94	4	,	,	,
cord-280878-1kt51viz	94	5	methyl	methyl	NN
cord-280878-1kt51viz	94	6	groups	group	NNS
cord-280878-1kt51viz	94	7	of	of	IN
cord-280878-1kt51viz	94	8	Val-27	Val-27	NNP
cord-280878-1kt51viz	94	9	and	and	CC
cord-280878-1kt51viz	94	10	Ala-30	Ala-30	NNP
cord-280878-1kt51viz	94	11	from	from	IN
cord-280878-1kt51viz	94	12	four	four	CD
cord-280878-1kt51viz	94	13	subunits	subunit	NNS
cord-280878-1kt51viz	94	14	form	form	VBP
cord-280878-1kt51viz	94	15	a	a	DT
cord-280878-1kt51viz	94	16	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	94	17	pocket	pocket	NN
cord-280878-1kt51viz	94	18	around	around	IN
cord-280878-1kt51viz	94	19	the	the	DT
cord-280878-1kt51viz	94	20	adamantane	adamantane	NNS
cord-280878-1kt51viz	94	21	,	,	,
cord-280878-1kt51viz	94	22	with	with	IN
cord-280878-1kt51viz	94	23	the	the	DT
cord-280878-1kt51viz	94	24	amino	amino	NN
cord-280878-1kt51viz	94	25	group	group	NN
cord-280878-1kt51viz	94	26	in	in	IN
cord-280878-1kt51viz	94	27	polar	polar	JJ
cord-280878-1kt51viz	94	28	contact	contact	NN
cord-280878-1kt51viz	94	29	with	with	IN
cord-280878-1kt51viz	94	30	the	the	DT
cord-280878-1kt51viz	94	31	backbone	backbone	NN
cord-280878-1kt51viz	94	32	oxygen	oxygen	NN
cord-280878-1kt51viz	94	33	of	of	IN
cord-280878-1kt51viz	94	34	Ala-30	Ala-30	NNP
cord-280878-1kt51viz	94	35	.	.	.
cord-280878-1kt51viz	95	1	This	this	DT
cord-280878-1kt51viz	95	2	ended	end	VBD
cord-280878-1kt51viz	95	3	the	the	DT
cord-280878-1kt51viz	95	4	controversy	controversy	NN
cord-280878-1kt51viz	95	5	,	,	,
cord-280878-1kt51viz	95	6	with	with	IN
cord-280878-1kt51viz	95	7	the	the	DT
cord-280878-1kt51viz	95	8	acceptance	acceptance	NN
cord-280878-1kt51viz	95	9	of	of	IN
cord-280878-1kt51viz	95	10	the	the	DT
cord-280878-1kt51viz	95	11	initially	initially	RB
cord-280878-1kt51viz	95	12	proposed	propose	VBN
cord-280878-1kt51viz	95	13	P	p	NN
cord-280878-1kt51viz	95	14	-	-	HYPH
cord-280878-1kt51viz	95	15	binding	bind	VBG
cord-280878-1kt51viz	95	16	site	site	NN
cord-280878-1kt51viz	95	17	.	.	.
cord-280878-1kt51viz	96	1	There	there	EX
cord-280878-1kt51viz	96	2	are	be	VBP
cord-280878-1kt51viz	96	3	12	12	CD
cord-280878-1kt51viz	96	4	structures	structure	NNS
cord-280878-1kt51viz	96	5	of	of	IN
cord-280878-1kt51viz	96	6	the	the	DT
cord-280878-1kt51viz	96	7	wild	wild	JJ
cord-280878-1kt51viz	96	8	-	-	HYPH
cord-280878-1kt51viz	96	9	type	type	NN
cord-280878-1kt51viz	96	10	and	and	CC
cord-280878-1kt51viz	96	11	drug	drug	NN
cord-280878-1kt51viz	96	12	-	-	HYPH
cord-280878-1kt51viz	96	13	resistant	resistant	JJ
cord-280878-1kt51viz	96	14	mutant	mutant	JJ
cord-280878-1kt51viz	96	15	M2	M2	NNP
cord-280878-1kt51viz	96	16	channels	channel	NNS
cord-280878-1kt51viz	96	17	available	available	JJ
cord-280878-1kt51viz	96	18	in	in	IN
cord-280878-1kt51viz	96	19	the	the	DT
cord-280878-1kt51viz	96	20	Protein	Protein	NNP
cord-280878-1kt51viz	96	21	Data	Data	NNP
cord-280878-1kt51viz	96	22	Bank	Bank	NNP
cord-280878-1kt51viz	96	23	solved	solve	VBN
cord-280878-1kt51viz	96	24	by	by	IN
cord-280878-1kt51viz	96	25	different	different	JJ
cord-280878-1kt51viz	96	26	techniques	technique	NNS
cord-280878-1kt51viz	96	27	and	and	CC
cord-280878-1kt51viz	96	28	conditions	condition	NNS
cord-280878-1kt51viz	96	29	(	(	-LRB-
cord-280878-1kt51viz	96	30	see	see	VB
cord-280878-1kt51viz	96	31	summary	summary	NN
cord-280878-1kt51viz	96	32	in	in	IN
cord-280878-1kt51viz	96	33	Gu	Gu	NNP
cord-280878-1kt51viz	96	34	et	et	NNP
cord-280878-1kt51viz	96	35	al	al	NNP
cord-280878-1kt51viz	96	36	.	.	NNP
cord-280878-1kt51viz	96	37	,	,	,
cord-280878-1kt51viz	96	38	2013	2013	CD
cord-280878-1kt51viz	96	39	)	)	-RRB-
cord-280878-1kt51viz	96	40	.	.	.
cord-280878-1kt51viz	97	1	Among	among	IN
cord-280878-1kt51viz	97	2	these	these	DT
cord-280878-1kt51viz	97	3	,	,	,
cord-280878-1kt51viz	97	4	structure	structure	NN
cord-280878-1kt51viz	97	5	2RLF	2rlf	CD
cord-280878-1kt51viz	97	6	solved	solve	VBN
cord-280878-1kt51viz	97	7	in	in	IN
cord-280878-1kt51viz	97	8	micelle	micelle	NN
cord-280878-1kt51viz	97	9	(	(	-LRB-
cord-280878-1kt51viz	97	10	Schnell	Schnell	NNP
cord-280878-1kt51viz	97	11	&	&	CC
cord-280878-1kt51viz	97	12	Chou	Chou	NNP
cord-280878-1kt51viz	97	13	,	,	,
cord-280878-1kt51viz	97	14	2008	2008	CD
cord-280878-1kt51viz	97	15	)	)	-RRB-
cord-280878-1kt51viz	97	16	and	and	CC
cord-280878-1kt51viz	97	17	structure	structure	NN
cord-280878-1kt51viz	97	18	2L0J	2l0j	CD
cord-280878-1kt51viz	97	19	in	in	IN
cord-280878-1kt51viz	97	20	the	the	DT
cord-280878-1kt51viz	97	21	bilayer	bilayer	NN
cord-280878-1kt51viz	97	22	environment	environment	NN
cord-280878-1kt51viz	97	23	contain	contain	VBP
cord-280878-1kt51viz	97	24	,	,	,
cord-280878-1kt51viz	97	25	in	in	IN
cord-280878-1kt51viz	97	26	addition	addition	NN
cord-280878-1kt51viz	97	27	to	to	IN
cord-280878-1kt51viz	97	28	the	the	DT
cord-280878-1kt51viz	97	29	TM	TM	NNP
cord-280878-1kt51viz	97	30	domain	domain	NN
cord-280878-1kt51viz	97	31	,	,	,
cord-280878-1kt51viz	97	32	short	short	JJ
cord-280878-1kt51viz	97	33	C	c	NN
cord-280878-1kt51viz	97	34	-	-	HYPH
cord-280878-1kt51viz	97	35	terminal	terminal	NN
cord-280878-1kt51viz	97	36	intracellular	intracellular	JJ
cord-280878-1kt51viz	97	37	amphipathic	amphipathic	NNP
cord-280878-1kt51viz	97	38	helices	helix	NNS
cord-280878-1kt51viz	97	39	.	.	.
cord-280878-1kt51viz	98	1	In	in	IN
cord-280878-1kt51viz	98	2	2RLF	2rlf	CD
cord-280878-1kt51viz	98	3	,	,	,
cord-280878-1kt51viz	98	4	the	the	DT
cord-280878-1kt51viz	98	5	C	c	NN
cord-280878-1kt51viz	98	6	-	-	HYPH
cord-280878-1kt51viz	98	7	terminal	terminal	NN
cord-280878-1kt51viz	98	8	helices	helix	NNS
cord-280878-1kt51viz	98	9	were	be	VBD
cord-280878-1kt51viz	98	10	connected	connect	VBN
cord-280878-1kt51viz	98	11	to	to	IN
cord-280878-1kt51viz	98	12	the	the	DT
cord-280878-1kt51viz	98	13	transmembrane	transmembrane	NN
cord-280878-1kt51viz	98	14	helices	helix	NNS
cord-280878-1kt51viz	98	15	via	via	IN
cord-280878-1kt51viz	98	16	a	a	DT
cord-280878-1kt51viz	98	17	short	short	JJ
cord-280878-1kt51viz	98	18	loop	loop	NN
cord-280878-1kt51viz	98	19	(	(	-LRB-
cord-280878-1kt51viz	98	20	residue	residue	NN
cord-280878-1kt51viz	98	21	47	47	CD
cord-280878-1kt51viz	98	22	-	-	SYM
cord-280878-1kt51viz	98	23	51	51	CD
cord-280878-1kt51viz	98	24	)	)	-RRB-
cord-280878-1kt51viz	98	25	and	and	CC
cord-280878-1kt51viz	98	26	were	be	VBD
cord-280878-1kt51viz	98	27	exposed	expose	VBN
cord-280878-1kt51viz	98	28	to	to	IN
cord-280878-1kt51viz	98	29	the	the	DT
cord-280878-1kt51viz	98	30	solution	solution	NN
cord-280878-1kt51viz	98	31	.	.	.
cord-280878-1kt51viz	99	1	However	however	RB
cord-280878-1kt51viz	99	2	,	,	,
cord-280878-1kt51viz	99	3	in	in	IN
cord-280878-1kt51viz	99	4	2L0J	2l0j	CD
cord-280878-1kt51viz	99	5	,	,	,
cord-280878-1kt51viz	99	6	the	the	DT
cord-280878-1kt51viz	99	7	C	c	NN
cord-280878-1kt51viz	99	8	-	-	HYPH
cord-280878-1kt51viz	99	9	terminal	terminal	NN
cord-280878-1kt51viz	99	10	helices	helix	NNS
cord-280878-1kt51viz	99	11	were	be	VBD
cord-280878-1kt51viz	99	12	connected	connect	VBN
cord-280878-1kt51viz	99	13	to	to	IN
cord-280878-1kt51viz	99	14	the	the	DT
cord-280878-1kt51viz	99	15	TM	TM	NNP
cord-280878-1kt51viz	99	16	helices	helix	NNS
cord-280878-1kt51viz	99	17	through	through	IN
cord-280878-1kt51viz	99	18	a	a	DT
cord-280878-1kt51viz	99	19	rigid	rigid	JJ
cord-280878-1kt51viz	99	20	turn	turn	NN
cord-280878-1kt51viz	99	21	(	(	-LRB-
cord-280878-1kt51viz	99	22	residue	residue	NN
cord-280878-1kt51viz	99	23	47	47	CD
cord-280878-1kt51viz	99	24	)	)	-RRB-
cord-280878-1kt51viz	99	25	and	and	CC
cord-280878-1kt51viz	99	26	were	be	VBD
cord-280878-1kt51viz	99	27	positioned	position	VBN
cord-280878-1kt51viz	99	28	on	on	IN
cord-280878-1kt51viz	99	29	the	the	DT
cord-280878-1kt51viz	99	30	bilayer	bilayer	NN
cord-280878-1kt51viz	99	31	surface	surface	NN
cord-280878-1kt51viz	99	32	(	(	-LRB-
cord-280878-1kt51viz	99	33	Sharma	Sharma	NNP
cord-280878-1kt51viz	99	34	et	et	NNP
cord-280878-1kt51viz	99	35	al	al	NNP
cord-280878-1kt51viz	99	36	.	.	NNP
cord-280878-1kt51viz	99	37	,	,	,
cord-280878-1kt51viz	99	38	2010	2010	CD
cord-280878-1kt51viz	99	39	)	)	-RRB-
cord-280878-1kt51viz	99	40	,	,	,
cord-280878-1kt51viz	99	41	and	and	CC
cord-280878-1kt51viz	99	42	this	this	DT
cord-280878-1kt51viz	99	43	conformation	conformation	NN
cord-280878-1kt51viz	99	44	was	be	VBD
cord-280878-1kt51viz	99	45	stabilized	stabilize	VBN
cord-280878-1kt51viz	99	46	by	by	IN
cord-280878-1kt51viz	99	47	extensive	extensive	JJ
cord-280878-1kt51viz	99	48	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	99	49	interactions	interaction	NNS
cord-280878-1kt51viz	99	50	among	among	IN
cord-280878-1kt51viz	99	51	these	these	DT
cord-280878-1kt51viz	99	52	helices	helix	NNS
cord-280878-1kt51viz	99	53	,	,	,
cord-280878-1kt51viz	99	54	and	and	CC
cord-280878-1kt51viz	99	55	polar	polar	JJ
cord-280878-1kt51viz	99	56	residues	residue	NNS
cord-280878-1kt51viz	99	57	Asp-44	Asp-44	NNP
cord-280878-1kt51viz	99	58	and	and	CC
cord-280878-1kt51viz	99	59	Arg-45	Arg-45	NNP
cord-280878-1kt51viz	99	60	were	be	VBD
cord-280878-1kt51viz	99	61	buried	bury	VBN
cord-280878-1kt51viz	99	62	by	by	IN
cord-280878-1kt51viz	99	63	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	99	64	residues	residue	NNS
cord-280878-1kt51viz	99	65	of	of	IN
cord-280878-1kt51viz	99	66	the	the	DT
cord-280878-1kt51viz	99	67	intracellular	intracellular	JJ
cord-280878-1kt51viz	99	68	amphipathic	amphipathic	NNP
cord-280878-1kt51viz	99	69	helices	helix	NNS
cord-280878-1kt51viz	99	70	,	,	,
cord-280878-1kt51viz	99	71	making	make	VBG
cord-280878-1kt51viz	99	72	the	the	DT
cord-280878-1kt51viz	99	73	S	s	NN
cord-280878-1kt51viz	99	74	-	-	HYPH
cord-280878-1kt51viz	99	75	binding	bind	VBG
cord-280878-1kt51viz	99	76	site	site	NN
cord-280878-1kt51viz	99	77	more	more	RBR
cord-280878-1kt51viz	99	78	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	99	79	than	than	IN
cord-280878-1kt51viz	99	80	that	that	DT
cord-280878-1kt51viz	99	81	in	in	IN
cord-280878-1kt51viz	99	82	micelles	micelle	NNS
cord-280878-1kt51viz	99	83	.	.	.
cord-280878-1kt51viz	100	1	Therefore	therefore	RB
cord-280878-1kt51viz	100	2	,	,	,
cord-280878-1kt51viz	100	3	the	the	DT
cord-280878-1kt51viz	100	4	S	s	NN
cord-280878-1kt51viz	100	5	-	-	HYPH
cord-280878-1kt51viz	100	6	binding	bind	VBG
cord-280878-1kt51viz	100	7	site	site	NN
cord-280878-1kt51viz	100	8	was	be	VBD
cord-280878-1kt51viz	100	9	absent	absent	JJ
cord-280878-1kt51viz	100	10	in	in	IN
cord-280878-1kt51viz	100	11	2L0J	2l0j	CD
cord-280878-1kt51viz	101	1	(	(	-LRB-
cord-280878-1kt51viz	101	2	Sharma	Sharma	NNP
cord-280878-1kt51viz	101	3	et	et	NNP
cord-280878-1kt51viz	101	4	al	al	NNP
cord-280878-1kt51viz	101	5	.	.	NNP
cord-280878-1kt51viz	101	6	,	,	,
cord-280878-1kt51viz	101	7	2010	2010	CD
cord-280878-1kt51viz	101	8	)	)	-RRB-
cord-280878-1kt51viz	101	9	.	.	.
cord-280878-1kt51viz	102	1	Molecular	molecular	JJ
cord-280878-1kt51viz	102	2	dynamics	dynamic	NNS
cord-280878-1kt51viz	102	3	simulations	simulation	NNS
cord-280878-1kt51viz	102	4	of	of	IN
cord-280878-1kt51viz	102	5	the	the	DT
cord-280878-1kt51viz	102	6	M2	M2	NNP
cord-280878-1kt51viz	102	7	proton	proton	NN
cord-280878-1kt51viz	102	8	channel	channel	NN
cord-280878-1kt51viz	102	9	with	with	IN
cord-280878-1kt51viz	102	10	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	102	11	binding	bind	VBG
cord-280878-1kt51viz	102	12	at	at	IN
cord-280878-1kt51viz	102	13	different	different	JJ
cord-280878-1kt51viz	102	14	sites	site	NNS
cord-280878-1kt51viz	102	15	have	have	VBP
cord-280878-1kt51viz	102	16	shown	show	VBN
cord-280878-1kt51viz	102	17	that	that	IN
cord-280878-1kt51viz	102	18	the	the	DT
cord-280878-1kt51viz	102	19	P	p	NN
cord-280878-1kt51viz	102	20	-	-	HYPH
cord-280878-1kt51viz	102	21	binding	bind	VBG
cord-280878-1kt51viz	102	22	site	site	NN
cord-280878-1kt51viz	102	23	is	be	VBZ
cord-280878-1kt51viz	102	24	more	more	RBR
cord-280878-1kt51viz	102	25	stable	stable	JJ
cord-280878-1kt51viz	102	26	for	for	IN
cord-280878-1kt51viz	102	27	drug	drug	NN
cord-280878-1kt51viz	102	28	binding	binding	NN
cord-280878-1kt51viz	102	29	,	,	,
cord-280878-1kt51viz	102	30	but	but	CC
cord-280878-1kt51viz	102	31	a	a	DT
cord-280878-1kt51viz	102	32	higher	high	JJR
cord-280878-1kt51viz	102	33	energy	energy	NN
cord-280878-1kt51viz	102	34	barrier	barrier	NN
cord-280878-1kt51viz	102	35	needs	need	VBZ
cord-280878-1kt51viz	102	36	to	to	TO
cord-280878-1kt51viz	102	37	be	be	VB
cord-280878-1kt51viz	102	38	overcome	overcome	VBN
cord-280878-1kt51viz	102	39	for	for	IN
cord-280878-1kt51viz	102	40	binding	bind	VBG
cord-280878-1kt51viz	102	41	to	to	TO
cord-280878-1kt51viz	102	42	occur	occur	VB
cord-280878-1kt51viz	103	1	(	(	-LRB-
cord-280878-1kt51viz	103	2	Gu	Gu	NNP
cord-280878-1kt51viz	103	3	et	et	FW
cord-280878-1kt51viz	103	4	al	al	NNP
cord-280878-1kt51viz	103	5	.	.	NNP
cord-280878-1kt51viz	103	6	,	,	,
cord-280878-1kt51viz	103	7	2011	2011	CD
cord-280878-1kt51viz	103	8	)	)	-RRB-
cord-280878-1kt51viz	103	9	.	.	.
cord-280878-1kt51viz	104	1	The	the	DT
cord-280878-1kt51viz	104	2	S	s	NN
cord-280878-1kt51viz	104	3	-	-	HYPH
cord-280878-1kt51viz	104	4	binding	bind	VBG
cord-280878-1kt51viz	104	5	site	site	NN
cord-280878-1kt51viz	104	6	was	be	VBD
cord-280878-1kt51viz	104	7	less	less	RBR
cord-280878-1kt51viz	104	8	stable	stable	JJ
cord-280878-1kt51viz	104	9	for	for	IN
cord-280878-1kt51viz	104	10	drug	drug	NN
cord-280878-1kt51viz	104	11	binding	binding	NN
cord-280878-1kt51viz	104	12	but	but	CC
cord-280878-1kt51viz	104	13	it	-PRON-	PRP
cord-280878-1kt51viz	104	14	was	be	VBD
cord-280878-1kt51viz	104	15	nearly	nearly	RB
cord-280878-1kt51viz	104	16	barrier	barrier	NN
cord-280878-1kt51viz	104	17	less	less	JJR
cord-280878-1kt51viz	104	18	and	and	CC
cord-280878-1kt51viz	104	19	was	be	VBD
cord-280878-1kt51viz	104	20	easily	easily	RB
cord-280878-1kt51viz	104	21	accessed	access	VBN
cord-280878-1kt51viz	104	22	.	.	.
cord-280878-1kt51viz	105	1	Therefore	therefore	RB
cord-280878-1kt51viz	105	2	,	,	,
cord-280878-1kt51viz	105	3	the	the	DT
cord-280878-1kt51viz	105	4	P	p	NN
cord-280878-1kt51viz	105	5	-	-	HYPH
cord-280878-1kt51viz	105	6	binding	bind	VBG
cord-280878-1kt51viz	105	7	site	site	NN
cord-280878-1kt51viz	105	8	represents	represent	VBZ
cord-280878-1kt51viz	105	9	the	the	DT
cord-280878-1kt51viz	105	10	thermodynamic	thermodynamic	JJ
cord-280878-1kt51viz	105	11	binding	binding	NN
cord-280878-1kt51viz	105	12	site	site	NN
cord-280878-1kt51viz	105	13	where	where	WRB
cord-280878-1kt51viz	105	14	the	the	DT
cord-280878-1kt51viz	105	15	drug	drug	NN
cord-280878-1kt51viz	105	16	molecule	molecule	NN
cord-280878-1kt51viz	105	17	binds	bind	VBZ
cord-280878-1kt51viz	105	18	slowly	slowly	RB
cord-280878-1kt51viz	105	19	and	and	CC
cord-280878-1kt51viz	105	20	stably	stably	RB
cord-280878-1kt51viz	105	21	and	and	CC
cord-280878-1kt51viz	105	22	dissociates	dissociate	VBZ
cord-280878-1kt51viz	105	23	even	even	RB
cord-280878-1kt51viz	105	24	more	more	RBR
cord-280878-1kt51viz	105	25	slowly	slowly	RB
cord-280878-1kt51viz	105	26	,	,	,
cord-280878-1kt51viz	105	27	whereas	whereas	IN
cord-280878-1kt51viz	105	28	the	the	DT
cord-280878-1kt51viz	105	29	S	s	NN
cord-280878-1kt51viz	105	30	-	-	HYPH
cord-280878-1kt51viz	105	31	binding	bind	VBG
cord-280878-1kt51viz	105	32	site	site	NN
cord-280878-1kt51viz	105	33	is	be	VBZ
cord-280878-1kt51viz	105	34	a	a	DT
cord-280878-1kt51viz	105	35	kinetic	kinetic	JJ
cord-280878-1kt51viz	105	36	binding	binding	NN
cord-280878-1kt51viz	105	37	site	site	NN
cord-280878-1kt51viz	105	38	where	where	WRB
cord-280878-1kt51viz	105	39	the	the	DT
cord-280878-1kt51viz	105	40	drug	drug	NN
cord-280878-1kt51viz	105	41	molecule	molecule	NN
cord-280878-1kt51viz	105	42	binds	bind	VBZ
cord-280878-1kt51viz	105	43	readily	readily	RB
cord-280878-1kt51viz	105	44	but	but	CC
cord-280878-1kt51viz	105	45	less	less	RBR
cord-280878-1kt51viz	105	46	stably	stably	RB
cord-280878-1kt51viz	105	47	and	and	CC
cord-280878-1kt51viz	105	48	dissociates	dissociate	VBZ
cord-280878-1kt51viz	105	49	easily	easily	RB
cord-280878-1kt51viz	105	50	.	.	.
cord-280878-1kt51viz	106	1	Over	over	IN
cord-280878-1kt51viz	106	2	the	the	DT
cord-280878-1kt51viz	106	3	last	last	JJ
cord-280878-1kt51viz	106	4	four	four	CD
cord-280878-1kt51viz	106	5	decades	decade	NNS
cord-280878-1kt51viz	106	6	,	,	,
cord-280878-1kt51viz	106	7	systematic	systematic	JJ
cord-280878-1kt51viz	106	8	studies	study	NNS
cord-280878-1kt51viz	106	9	of	of	IN
cord-280878-1kt51viz	106	10	amantadine	amantadine	NNP
cord-280878-1kt51viz	106	11	analogues	analogue	NNS
cord-280878-1kt51viz	106	12	and	and	CC
cord-280878-1kt51viz	106	13	library	library	NN
cord-280878-1kt51viz	106	14	screening	screening	NN
cord-280878-1kt51viz	106	15	have	have	VBP
cord-280878-1kt51viz	106	16	elucidated	elucidate	VBN
cord-280878-1kt51viz	106	17	structure	structure	NN
cord-280878-1kt51viz	106	18	-	-	HYPH
cord-280878-1kt51viz	106	19	activity	activity	NN
cord-280878-1kt51viz	106	20	relationships	relationship	NNS
cord-280878-1kt51viz	106	21	(	(	-LRB-
cord-280878-1kt51viz	106	22	SARs	SARs	NNP
cord-280878-1kt51viz	106	23	)	)	-RRB-
cord-280878-1kt51viz	106	24	and	and	CC
cord-280878-1kt51viz	106	25	helped	help	VBD
cord-280878-1kt51viz	106	26	to	to	TO
cord-280878-1kt51viz	106	27	identify	identify	VB
cord-280878-1kt51viz	106	28	potent	potent	JJ
cord-280878-1kt51viz	106	29	wild	wild	JJ
cord-280878-1kt51viz	106	30	-	-	HYPH
cord-280878-1kt51viz	106	31	type	type	NN
cord-280878-1kt51viz	106	32	(	(	-LRB-
cord-280878-1kt51viz	106	33	WT	wt	NN
cord-280878-1kt51viz	106	34	)	)	-RRB-
cord-280878-1kt51viz	107	1	AM2	am2	JJ
cord-280878-1kt51viz	107	2	channel	channel	NN
cord-280878-1kt51viz	107	3	blockers	blocker	NNS
cord-280878-1kt51viz	107	4	(	(	-LRB-
cord-280878-1kt51viz	107	5	De	De	NNP
cord-280878-1kt51viz	107	6	Clercq	Clercq	NNP
cord-280878-1kt51viz	107	7	,	,	,
cord-280878-1kt51viz	107	8	2006	2006	CD
cord-280878-1kt51viz	107	9	;	;	:
cord-280878-1kt51viz	107	10	Lagoja	Lagoja	NNP
cord-280878-1kt51viz	107	11	&	&	CC
cord-280878-1kt51viz	107	12	De	De	NNP
cord-280878-1kt51viz	107	13	Clercq	Clercq	NNP
cord-280878-1kt51viz	107	14	,	,	,
cord-280878-1kt51viz	107	15	2008	2008	CD
cord-280878-1kt51viz	107	16	)	)	-RRB-
cord-280878-1kt51viz	107	17	.	.	.
cord-280878-1kt51viz	108	1	Several	several	JJ
cord-280878-1kt51viz	108	2	other	other	JJ
cord-280878-1kt51viz	108	3	molecules	molecule	NNS
cord-280878-1kt51viz	108	4	were	be	VBD
cord-280878-1kt51viz	108	5	not	not	RB
cord-280878-1kt51viz	108	6	based	base	VBN
cord-280878-1kt51viz	108	7	on	on	IN
cord-280878-1kt51viz	108	8	adamantanes	adamantane	NNS
cord-280878-1kt51viz	108	9	.	.	.
cord-280878-1kt51viz	109	1	For	for	IN
cord-280878-1kt51viz	109	2	example	example	NN
cord-280878-1kt51viz	109	3	,	,	,
cord-280878-1kt51viz	109	4	the	the	DT
cord-280878-1kt51viz	109	5	spirene	spirene	JJ
cord-280878-1kt51viz	109	6	guanidine	guanidine	NNP
cord-280878-1kt51viz	109	7	analogue	analogue	NNP
cord-280878-1kt51viz	109	8	,	,	,
cord-280878-1kt51viz	109	9	2-[3-azaspiro(5,5)undecanol]-2-imidazoline	2-[3-azaspiro(5,5)undecanol]-2-imidazoline	NNP
cord-280878-1kt51viz	109	10	(	(	-LRB-
cord-280878-1kt51viz	109	11	BL-1743	BL-1743	NNP
cord-280878-1kt51viz	109	12	)	)	-RRB-
cord-280878-1kt51viz	109	13	(	(	-LRB-
cord-280878-1kt51viz	109	14	Fig	Fig	NNP
cord-280878-1kt51viz	109	15	.	.	.
cord-280878-1kt51viz	109	16	2A	2a	CD
cord-280878-1kt51viz	109	17	)	)	-RRB-
cord-280878-1kt51viz	109	18	was	be	VBD
cord-280878-1kt51viz	109	19	discovered	discover	VBN
cord-280878-1kt51viz	109	20	during	during	IN
cord-280878-1kt51viz	109	21	a	a	DT
cord-280878-1kt51viz	109	22	high	high	JJ
cord-280878-1kt51viz	109	23	-	-	HYPH
cord-280878-1kt51viz	109	24	throughput	throughput	NN
cord-280878-1kt51viz	109	25	screen	screen	NN
cord-280878-1kt51viz	109	26	based	base	VBN
cord-280878-1kt51viz	109	27	on	on	IN
cord-280878-1kt51viz	109	28	the	the	DT
cord-280878-1kt51viz	109	29	ability	ability	NN
cord-280878-1kt51viz	109	30	of	of	IN
cord-280878-1kt51viz	109	31	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	109	32	to	to	TO
cord-280878-1kt51viz	109	33	reverse	reverse	VB
cord-280878-1kt51viz	109	34	the	the	DT
cord-280878-1kt51viz	109	35	toxicity	toxicity	NN
cord-280878-1kt51viz	109	36	associated	associate	VBN
cord-280878-1kt51viz	109	37	with	with	IN
cord-280878-1kt51viz	109	38	M2	M2	NNP
cord-280878-1kt51viz	109	39	channels	channel	NNS
cord-280878-1kt51viz	109	40	expressed	express	VBN
cord-280878-1kt51viz	109	41	in	in	IN
cord-280878-1kt51viz	109	42	the	the	DT
cord-280878-1kt51viz	109	43	yeast	yeast	NN
cord-280878-1kt51viz	109	44	Saccharomyces	Saccharomyces	NNP
cord-280878-1kt51viz	109	45	cerevisiae	cerevisiae	NNS
cord-280878-1kt51viz	109	46	(	(	-LRB-
cord-280878-1kt51viz	109	47	Kurtz	Kurtz	NNP
cord-280878-1kt51viz	109	48	et	et	NNP
cord-280878-1kt51viz	109	49	al	al	NNP
cord-280878-1kt51viz	109	50	.	.	NNP
cord-280878-1kt51viz	109	51	,	,	,
cord-280878-1kt51viz	109	52	1995	1995	CD
cord-280878-1kt51viz	109	53	)	)	-RRB-
cord-280878-1kt51viz	109	54	.	.	.
cord-280878-1kt51viz	110	1	Based	base	VBN
cord-280878-1kt51viz	110	2	on	on	IN
cord-280878-1kt51viz	110	3	this	this	DT
cord-280878-1kt51viz	110	4	nonadamantane	nonadamantane	NN
cord-280878-1kt51viz	110	5	,	,	,
cord-280878-1kt51viz	110	6	a	a	DT
cord-280878-1kt51viz	110	7	SAR	SAR	NNP
cord-280878-1kt51viz	110	8	study	study	NN
cord-280878-1kt51viz	110	9	using	use	VBG
cord-280878-1kt51viz	110	10	a	a	DT
cord-280878-1kt51viz	110	11	combination	combination	NN
cord-280878-1kt51viz	110	12	of	of	IN
cord-280878-1kt51viz	110	13	viral	viral	JJ
cord-280878-1kt51viz	110	14	plaque	plaque	NN
cord-280878-1kt51viz	110	15	assays	assay	NNS
cord-280878-1kt51viz	110	16	and	and	CC
cord-280878-1kt51viz	110	17	two	two	CD
cord-280878-1kt51viz	110	18	-	-	HYPH
cord-280878-1kt51viz	110	19	electrode	electrode	NN
cord-280878-1kt51viz	110	20	voltage	voltage	NN
cord-280878-1kt51viz	110	21	clamp	clamp	NN
cord-280878-1kt51viz	110	22	(	(	-LRB-
cord-280878-1kt51viz	110	23	TEVC	TEVC	NNP
cord-280878-1kt51viz	110	24	)	)	-RRB-
cord-280878-1kt51viz	110	25	(	(	-LRB-
cord-280878-1kt51viz	110	26	Wang	Wang	NNP
cord-280878-1kt51viz	110	27	,	,	,
cord-280878-1kt51viz	110	28	Cady	Cady	NNP
cord-280878-1kt51viz	110	29	,	,	,
cord-280878-1kt51viz	110	30	et	et	NNP
cord-280878-1kt51viz	110	31	al	al	NNP
cord-280878-1kt51viz	110	32	.	.	NNP
cord-280878-1kt51viz	110	33	,	,	,
cord-280878-1kt51viz	110	34	2009	2009	CD
cord-280878-1kt51viz	110	35	)	)	-RRB-
cord-280878-1kt51viz	110	36	generated	generate	VBD
cord-280878-1kt51viz	110	37	3-azaspiro[5,5]undecane	3-azaspiro[5,5]undecane	CD
cord-280878-1kt51viz	110	38	hydrochloride	hydrochloride	NN
cord-280878-1kt51viz	110	39	(	(	-LRB-
cord-280878-1kt51viz	110	40	Fig	Fig	NNP
cord-280878-1kt51viz	110	41	.	.	.
cord-280878-1kt51viz	110	42	2B	2B	NNP
cord-280878-1kt51viz	110	43	)	)	-RRB-
cord-280878-1kt51viz	110	44	,	,	,
cord-280878-1kt51viz	110	45	which	which	WDT
cord-280878-1kt51viz	110	46	lacks	lack	VBZ
cord-280878-1kt51viz	110	47	the	the	DT
cord-280878-1kt51viz	110	48	(	(	-LRB-
cord-280878-1kt51viz	110	49	Wang	Wang	NNP
cord-280878-1kt51viz	110	50	,	,	,
cord-280878-1kt51viz	110	51	Cady	Cady	NNP
cord-280878-1kt51viz	110	52	,	,	,
cord-280878-1kt51viz	110	53	et	et	NNP
cord-280878-1kt51viz	110	54	al	al	NNP
cord-280878-1kt51viz	110	55	.	.	NNP
cord-280878-1kt51viz	110	56	,	,	,
cord-280878-1kt51viz	110	57	2009	2009	CD
cord-280878-1kt51viz	110	58	)	)	-RRB-
cord-280878-1kt51viz	110	59	.	.	.
cord-280878-1kt51viz	111	1	imidazoline	imidazoline	NNP
cord-280878-1kt51viz	111	2	group	group	NNP
cord-280878-1kt51viz	111	3	of	of	IN
cord-280878-1kt51viz	111	4	BL-1743	BL-1743	NNP
cord-280878-1kt51viz	111	5	.	.	.
cord-280878-1kt51viz	112	1	This	this	DT
cord-280878-1kt51viz	112	2	compound	compound	NN
cord-280878-1kt51viz	112	3	showed	show	VBD
cord-280878-1kt51viz	112	4	an	an	DT
cord-280878-1kt51viz	112	5	IC	IC	NNP
cord-280878-1kt51viz	112	6	50	50	CD
cord-280878-1kt51viz	112	7	of	of	IN
cord-280878-1kt51viz	112	8	0.92	0.92	CD
cord-280878-1kt51viz	112	9	AE	AE	NNP
cord-280878-1kt51viz	112	10	0.11	0.11	CD
cord-280878-1kt51viz	113	1	μM	μM	NNP
cord-280878-1kt51viz	113	2	against	against	IN
cord-280878-1kt51viz	113	3	AM2	AM2	NNP
cord-280878-1kt51viz	113	4	,	,	,
cord-280878-1kt51viz	113	5	ie	ie	NNS
cord-280878-1kt51viz	113	6	,	,	,
cord-280878-1kt51viz	113	7	more	more	JJR
cord-280878-1kt51viz	113	8	than	than	IN
cord-280878-1kt51viz	113	9	an	an	DT
cord-280878-1kt51viz	113	10	order	order	NN
cord-280878-1kt51viz	113	11	of	of	IN
cord-280878-1kt51viz	113	12	magnitude	magnitude	NN
cord-280878-1kt51viz	113	13	more	more	RBR
cord-280878-1kt51viz	113	14	potent	potent	JJ
cord-280878-1kt51viz	113	15	than	than	IN
cord-280878-1kt51viz	113	16	amantadine	amantadine	NNP
cord-280878-1kt51viz	113	17	(	(	-LRB-
cord-280878-1kt51viz	113	18	IC	IC	NNP
cord-280878-1kt51viz	113	19	50	50	CD
cord-280878-1kt51viz	113	20	¼	¼	CD
cord-280878-1kt51viz	113	21	16	16	CD
cord-280878-1kt51viz	114	1	μM	μM	NNP
cord-280878-1kt51viz	114	2	)	)	-RRB-
cord-280878-1kt51viz	115	1	and	and	CC
cord-280878-1kt51viz	115	2	more	more	JJR
cord-280878-1kt51viz	115	3	than	than	IN
cord-280878-1kt51viz	115	4	45-fold	45-fold	CD
cord-280878-1kt51viz	115	5	increase	increase	NN
cord-280878-1kt51viz	115	6	in	in	IN
cord-280878-1kt51viz	115	7	potency	potency	NN
cord-280878-1kt51viz	115	8	relative	relative	NN
cord-280878-1kt51viz	115	9	to	to	IN
cord-280878-1kt51viz	115	10	the	the	DT
cord-280878-1kt51viz	115	11	parental	parental	JJ
cord-280878-1kt51viz	115	12	BL-1743	BL-1743	NNP
cord-280878-1kt51viz	115	13	.	.	.
cord-280878-1kt51viz	116	1	Compared	compare	VBN
cord-280878-1kt51viz	116	2	to	to	IN
cord-280878-1kt51viz	116	3	Amt	Amt	NNP
cord-280878-1kt51viz	116	4	,	,	,
cord-280878-1kt51viz	116	5	this	this	DT
cord-280878-1kt51viz	116	6	spiro	spiro	NNP
cord-280878-1kt51viz	116	7	-	-	HYPH
cord-280878-1kt51viz	116	8	piperidine	piperidine	NNP
cord-280878-1kt51viz	116	9	induced	induce	VBD
cord-280878-1kt51viz	116	10	a	a	DT
cord-280878-1kt51viz	116	11	more	more	RBR
cord-280878-1kt51viz	116	12	homogeneous	homogeneous	JJ
cord-280878-1kt51viz	116	13	conformation	conformation	NN
cord-280878-1kt51viz	116	14	of	of	IN
cord-280878-1kt51viz	116	15	the	the	DT
cord-280878-1kt51viz	116	16	AM2	am2	JJ
cord-280878-1kt51viz	116	17	peptide	peptide	NN
cord-280878-1kt51viz	116	18	,	,	,
cord-280878-1kt51viz	116	19	reducing	reduce	VBG
cord-280878-1kt51viz	116	20	dynamic	dynamic	JJ
cord-280878-1kt51viz	116	21	disorder	disorder	NN
cord-280878-1kt51viz	116	22	near	near	IN
cord-280878-1kt51viz	116	23	the	the	DT
cord-280878-1kt51viz	116	24	water	water	NN
cord-280878-1kt51viz	116	25	-	-	HYPH
cord-280878-1kt51viz	116	26	filled	fill	VBN
cord-280878-1kt51viz	116	27	central	central	JJ
cord-280878-1kt51viz	116	28	cavity	cavity	NN
cord-280878-1kt51viz	116	29	of	of	IN
cord-280878-1kt51viz	116	30	the	the	DT
cord-280878-1kt51viz	116	31	helical	helical	JJ
cord-280878-1kt51viz	116	32	bundle	bundle	NN
cord-280878-1kt51viz	116	33	,	,	,
cord-280878-1kt51viz	116	34	suggesting	suggest	VBG
cord-280878-1kt51viz	116	35	a	a	DT
cord-280878-1kt51viz	116	36	more	more	RBR
cord-280878-1kt51viz	116	37	extensive	extensive	JJ
cord-280878-1kt51viz	116	38	binding	binding	NN
cord-280878-1kt51viz	116	39	to	to	IN
cord-280878-1kt51viz	116	40	the	the	DT
cord-280878-1kt51viz	116	41	AM2	am2	JJ
cord-280878-1kt51viz	116	42	channel	channel	NN
cord-280878-1kt51viz	116	43	,	,	,
cord-280878-1kt51viz	116	44	thus	thus	RB
cord-280878-1kt51viz	116	45	leading	lead	VBG
cord-280878-1kt51viz	116	46	to	to	IN
cord-280878-1kt51viz	116	47	stronger	strong	JJR
cord-280878-1kt51viz	116	48	inhibitory	inhibitory	JJ
cord-280878-1kt51viz	116	49	potency	potency	NN
cord-280878-1kt51viz	116	50	.	.	.
cord-280878-1kt51viz	117	1	However	however	RB
cord-280878-1kt51viz	117	2	,	,	,
cord-280878-1kt51viz	117	3	this	this	DT
cord-280878-1kt51viz	117	4	compound	compound	NN
cord-280878-1kt51viz	117	5	was	be	VBD
cord-280878-1kt51viz	117	6	only	only	RB
cord-280878-1kt51viz	117	7	effective	effective	JJ
cord-280878-1kt51viz	117	8	against	against	IN
cord-280878-1kt51viz	117	9	the	the	DT
cord-280878-1kt51viz	117	10	wild	wild	JJ
cord-280878-1kt51viz	117	11	-	-	HYPH
cord-280878-1kt51viz	117	12	type	type	NN
cord-280878-1kt51viz	117	13	AM2	am2	NN
cord-280878-1kt51viz	117	14	.	.	.
cord-280878-1kt51viz	118	1	This	this	DT
cord-280878-1kt51viz	118	2	is	be	VBZ
cord-280878-1kt51viz	118	3	crucial	crucial	JJ
cord-280878-1kt51viz	118	4	because	because	IN
cord-280878-1kt51viz	118	5	of	of	IN
cord-280878-1kt51viz	118	6	the	the	DT
cord-280878-1kt51viz	118	7	current	current	JJ
cord-280878-1kt51viz	118	8	prevalence	prevalence	NN
cord-280878-1kt51viz	118	9	of	of	IN
cord-280878-1kt51viz	118	10	Amt	amt	JJ
cord-280878-1kt51viz	118	11	-	-	HYPH
cord-280878-1kt51viz	118	12	resistant	resistant	JJ
cord-280878-1kt51viz	118	13	variants	variant	NNS
cord-280878-1kt51viz	118	14	of	of	IN
cord-280878-1kt51viz	118	15	AM2	AM2	NNP
cord-280878-1kt51viz	118	16	,	,	,
cord-280878-1kt51viz	118	17	eg	eg	NNS
cord-280878-1kt51viz	118	18	,	,	,
cord-280878-1kt51viz	118	19	L26F	l26f	NN
cord-280878-1kt51viz	118	20	,	,	,
cord-280878-1kt51viz	118	21	V27A	V27A	NNS
cord-280878-1kt51viz	118	22	,	,	,
cord-280878-1kt51viz	118	23	and	and	CC
cord-280878-1kt51viz	118	24	S31N	S31N	NNP
cord-280878-1kt51viz	118	25	,	,	,
cord-280878-1kt51viz	118	26	which	which	WDT
cord-280878-1kt51viz	118	27	comprise	comprise	VBP
cord-280878-1kt51viz	118	28	more	more	JJR
cord-280878-1kt51viz	118	29	than	than	IN
cord-280878-1kt51viz	118	30	99	99	CD
cord-280878-1kt51viz	118	31	%	%	NN
cord-280878-1kt51viz	118	32	of	of	IN
cord-280878-1kt51viz	118	33	the	the	DT
cord-280878-1kt51viz	118	34	reported	report	VBN
cord-280878-1kt51viz	118	35	resistance	resistance	NN
cord-280878-1kt51viz	118	36	mutants	mutant	NNS
cord-280878-1kt51viz	118	37	(	(	-LRB-
cord-280878-1kt51viz	118	38	Furuse	Furuse	NNP
cord-280878-1kt51viz	118	39	,	,	,
cord-280878-1kt51viz	118	40	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	118	41	,	,	,
cord-280878-1kt51viz	118	42	&	&	CC
cord-280878-1kt51viz	118	43	Oshitani	Oshitani	NNP
cord-280878-1kt51viz	118	44	,	,	,
cord-280878-1kt51viz	118	45	2009	2009	CD
cord-280878-1kt51viz	118	46	;	;	:
cord-280878-1kt51viz	118	47	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	118	48	et	et	NNP
cord-280878-1kt51viz	118	49	al	al	NNP
cord-280878-1kt51viz	118	50	.	.	NNP
cord-280878-1kt51viz	118	51	,	,	,
cord-280878-1kt51viz	118	52	2003	2003	CD
cord-280878-1kt51viz	118	53	)	)	-RRB-
cord-280878-1kt51viz	118	54	.	.	.
cord-280878-1kt51viz	119	1	Of	of	IN
cord-280878-1kt51viz	119	2	these	these	DT
cord-280878-1kt51viz	119	3	three	three	CD
cord-280878-1kt51viz	119	4	mutations	mutation	NNS
cord-280878-1kt51viz	119	5	,	,	,
cord-280878-1kt51viz	119	6	V27A	V27A	NNP
cord-280878-1kt51viz	119	7	is	be	VBZ
cord-280878-1kt51viz	119	8	the	the	DT
cord-280878-1kt51viz	119	9	only	only	JJ
cord-280878-1kt51viz	119	10	one	one	CD
cord-280878-1kt51viz	119	11	known	know	VBN
cord-280878-1kt51viz	119	12	to	to	TO
cord-280878-1kt51viz	119	13	originate	originate	VB
cord-280878-1kt51viz	119	14	from	from	IN
cord-280878-1kt51viz	119	15	drug	drug	NN
cord-280878-1kt51viz	119	16	selection	selection	NN
cord-280878-1kt51viz	119	17	pressure	pressure	NN
cord-280878-1kt51viz	119	18	(	(	-LRB-
cord-280878-1kt51viz	119	19	Furuse	Furuse	NNP
cord-280878-1kt51viz	119	20	et	et	NNP
cord-280878-1kt51viz	119	21	al	al	NNP
cord-280878-1kt51viz	119	22	.	.	NNP
cord-280878-1kt51viz	119	23	,	,	,
cord-280878-1kt51viz	119	24	2009	2009	CD
cord-280878-1kt51viz	119	25	)	)	-RRB-
cord-280878-1kt51viz	119	26	,	,	,
cord-280878-1kt51viz	119	27	and	and	CC
cord-280878-1kt51viz	119	28	this	this	DT
cord-280878-1kt51viz	119	29	mutant	mutant	NN
cord-280878-1kt51viz	119	30	is	be	VBZ
cord-280878-1kt51viz	119	31	the	the	DT
cord-280878-1kt51viz	119	32	only	only	JJ
cord-280878-1kt51viz	119	33	one	one	CD
cord-280878-1kt51viz	119	34	among	among	IN
cord-280878-1kt51viz	119	35	the	the	DT
cord-280878-1kt51viz	119	36	three	three	CD
cord-280878-1kt51viz	119	37	that	that	WDT
cord-280878-1kt51viz	119	38	is	be	VBZ
cord-280878-1kt51viz	119	39	completely	completely	RB
cord-280878-1kt51viz	119	40	resistant	resistant	JJ
cord-280878-1kt51viz	119	41	to	to	IN
cord-280878-1kt51viz	119	42	Amt	Amt	NNP
cord-280878-1kt51viz	119	43	and	and	CC
cord-280878-1kt51viz	119	44	Rim	Rim	NNP
cord-280878-1kt51viz	119	45	)	)	-RRB-
cord-280878-1kt51viz	119	46	.	.	.
cord-280878-1kt51viz	120	1	On	on	IN
cord-280878-1kt51viz	120	2	the	the	DT
cord-280878-1kt51viz	120	3	other	other	JJ
cord-280878-1kt51viz	120	4	hand	hand	NN
cord-280878-1kt51viz	120	5	,	,	,
cord-280878-1kt51viz	120	6	S31N	S31N	NNP
cord-280878-1kt51viz	120	7	is	be	VBZ
cord-280878-1kt51viz	120	8	found	find	VBN
cord-280878-1kt51viz	120	9	in	in	IN
cord-280878-1kt51viz	120	10	more	more	JJR
cord-280878-1kt51viz	120	11	than	than	IN
cord-280878-1kt51viz	120	12	98	98	CD
cord-280878-1kt51viz	120	13	%	%	NN
cord-280878-1kt51viz	120	14	of	of	IN
cord-280878-1kt51viz	120	15	the	the	DT
cord-280878-1kt51viz	120	16	mutated	mutate	VBN
cord-280878-1kt51viz	120	17	M2	M2	NNP
cord-280878-1kt51viz	120	18	channels	channel	NNS
cord-280878-1kt51viz	120	19	in	in	IN
cord-280878-1kt51viz	120	20	the	the	DT
cord-280878-1kt51viz	120	21	IAV	IAV	NNP
cord-280878-1kt51viz	120	22	subtype	subtype	NN
cord-280878-1kt51viz	120	23	H3N2	H3N2	NNP
cord-280878-1kt51viz	120	24	viruses	virus	NNS
cord-280878-1kt51viz	120	25	(	(	-LRB-
cord-280878-1kt51viz	120	26	Bright	bright	JJ
cord-280878-1kt51viz	120	27	et	et	FW
cord-280878-1kt51viz	120	28	al	al	NNP
cord-280878-1kt51viz	120	29	.	.	NNP
cord-280878-1kt51viz	120	30	,	,	,
cord-280878-1kt51viz	120	31	2005	2005	CD
cord-280878-1kt51viz	120	32	)	)	-RRB-
cord-280878-1kt51viz	120	33	,	,	,
cord-280878-1kt51viz	120	34	and	and	CC
cord-280878-1kt51viz	120	35	causes	cause	VBZ
cord-280878-1kt51viz	120	36	a	a	DT
cord-280878-1kt51viz	120	37	10	10	CD
cord-280878-1kt51viz	120	38	-	-	SYM
cord-280878-1kt51viz	120	39	20	20	CD
cord-280878-1kt51viz	120	40	times	time	NNS
cord-280878-1kt51viz	120	41	decrease	decrease	VB
cord-280878-1kt51viz	120	42	in	in	IN
cord-280878-1kt51viz	120	43	the	the	DT
cord-280878-1kt51viz	120	44	IC	IC	NNP
cord-280878-1kt51viz	120	45	50	50	CD
cord-280878-1kt51viz	120	46	,	,	,
cord-280878-1kt51viz	120	47	from	from	IN
cord-280878-1kt51viz	120	48	low	low	JJ
cord-280878-1kt51viz	120	49	micromolar	micromolar	JJ
cord-280878-1kt51viz	120	50	to	to	IN
cord-280878-1kt51viz	120	51	200	200	CD
cord-280878-1kt51viz	121	1	μM	μM	NNP
cord-280878-1kt51viz	122	1	(	(	-LRB-
cord-280878-1kt51viz	122	2	Amt	Amt	NNP
cord-280878-1kt51viz	122	3	)	)	-RRB-
cord-280878-1kt51viz	122	4	and	and	CC
cord-280878-1kt51viz	122	5	more	more	JJR
cord-280878-1kt51viz	122	6	than	than	IN
cord-280878-1kt51viz	122	7	2	2	CD
cord-280878-1kt51viz	122	8	mM	mm	CD
cord-280878-1kt51viz	122	9	(	(	-LRB-
cord-280878-1kt51viz	122	10	Rim	rim	NN
cord-280878-1kt51viz	122	11	)	)	-RRB-
cord-280878-1kt51viz	122	12	.	.	.
cord-280878-1kt51viz	123	1	The	the	DT
cord-280878-1kt51viz	123	2	first	first	JJ
cord-280878-1kt51viz	123	3	non	non	JJ
cord-280878-1kt51viz	123	4	-	-	JJ
cord-280878-1kt51viz	123	5	adamantane	adamantane	JJ
cord-280878-1kt51viz	123	6	inhibitor	inhibitor	NN
cord-280878-1kt51viz	123	7	of	of	IN
cord-280878-1kt51viz	123	8	the	the	DT
cord-280878-1kt51viz	123	9	V27A	V27A	NNP
cord-280878-1kt51viz	123	10	mutant	mutant	NN
cord-280878-1kt51viz	123	11	was	be	VBD
cord-280878-1kt51viz	123	12	a	a	DT
cord-280878-1kt51viz	123	13	polycyclic	polycyclic	JJ
cord-280878-1kt51viz	123	14	pyrrolidine	pyrrolidine	NN
cord-280878-1kt51viz	123	15	,	,	,
cord-280878-1kt51viz	123	16	a	a	DT
cord-280878-1kt51viz	123	17	dual	dual	JJ
cord-280878-1kt51viz	123	18	inhibitor	inhibitor	NN
cord-280878-1kt51viz	123	19	of	of	IN
cord-280878-1kt51viz	123	20	WT	WT	NNP
cord-280878-1kt51viz	123	21	(	(	-LRB-
cord-280878-1kt51viz	123	22	IC	IC	NNP
cord-280878-1kt51viz	123	23	50	50	CD
cord-280878-1kt51viz	123	24	of	of	IN
cord-280878-1kt51viz	123	25	3.4	3.4	CD
cord-280878-1kt51viz	123	26	μM	μM	NNP
cord-280878-1kt51viz	123	27	)	)	-RRB-
cord-280878-1kt51viz	123	28	and	and	CC
cord-280878-1kt51viz	123	29	V27A	V27A	NNS
cord-280878-1kt51viz	123	30	(	(	-LRB-
cord-280878-1kt51viz	123	31	IC	IC	NNP
cord-280878-1kt51viz	123	32	50	50	CD
cord-280878-1kt51viz	123	33	of	of	IN
cord-280878-1kt51viz	123	34	0.29	0.29	CD
cord-280878-1kt51viz	123	35	μM	μm	NN
cord-280878-1kt51viz	123	36	)	)	-RRB-
cord-280878-1kt51viz	124	1	(	(	-LRB-
cord-280878-1kt51viz	124	2	Rey	Rey	NNP
cord-280878-1kt51viz	124	3	-	-	HYPH
cord-280878-1kt51viz	124	4	Carrizo	Carrizo	NNP
cord-280878-1kt51viz	124	5	et	et	NNP
cord-280878-1kt51viz	124	6	al	al	NNP
cord-280878-1kt51viz	124	7	.	.	NNP
cord-280878-1kt51viz	124	8	,	,	,
cord-280878-1kt51viz	124	9	2013	2013	CD
cord-280878-1kt51viz	124	10	)	)	-RRB-
cord-280878-1kt51viz	124	11	.	.	.
cord-280878-1kt51viz	125	1	Later	later	RB
cord-280878-1kt51viz	125	2	,	,	,
cord-280878-1kt51viz	125	3	a	a	DT
cord-280878-1kt51viz	125	4	compound	compound	NN
cord-280878-1kt51viz	125	5	with	with	IN
cord-280878-1kt51viz	125	6	triple	triple	JJ
cord-280878-1kt51viz	125	7	inhibitor	inhibitor	NN
cord-280878-1kt51viz	125	8	efficacy	efficacy	NN
cord-280878-1kt51viz	125	9	was	be	VBD
cord-280878-1kt51viz	125	10	reported	report	VBN
cord-280878-1kt51viz	125	11	by	by	IN
cord-280878-1kt51viz	125	12	the	the	DT
cord-280878-1kt51viz	125	13	same	same	JJ
cord-280878-1kt51viz	125	14	authors	author	NNS
cord-280878-1kt51viz	125	15	,	,	,
cord-280878-1kt51viz	125	16	active	active	JJ
cord-280878-1kt51viz	125	17	against	against	IN
cord-280878-1kt51viz	125	18	the	the	DT
cord-280878-1kt51viz	125	19	WT	WT	NNP
cord-280878-1kt51viz	125	20	,	,	,
cord-280878-1kt51viz	125	21	V27A	V27A	NNS
cord-280878-1kt51viz	125	22	,	,	,
cord-280878-1kt51viz	125	23	and	and	CC
cord-280878-1kt51viz	125	24	L26F	l26f	NN
cord-280878-1kt51viz	125	25	mutants	mutant	NNS
cord-280878-1kt51viz	125	26	,	,	,
cord-280878-1kt51viz	125	27	with	with	IN
cord-280878-1kt51viz	125	28	IC	IC	NNP
cord-280878-1kt51viz	125	29	50	50	CD
cord-280878-1kt51viz	125	30	of	of	IN
cord-280878-1kt51viz	125	31	18	18	CD
cord-280878-1kt51viz	125	32	,	,	,
cord-280878-1kt51viz	125	33	0.7	0.7	CD
cord-280878-1kt51viz	125	34	,	,	,
cord-280878-1kt51viz	125	35	and	and	CC
cord-280878-1kt51viz	125	36	9	9	CD
cord-280878-1kt51viz	125	37	μM	μm	CD
cord-280878-1kt51viz	125	38	,	,	,
cord-280878-1kt51viz	125	39	respectively	respectively	RB
cord-280878-1kt51viz	125	40	(	(	-LRB-
cord-280878-1kt51viz	125	41	Rey	Rey	NNP
cord-280878-1kt51viz	125	42	-	-	HYPH
cord-280878-1kt51viz	125	43	Carrizo	Carrizo	NNP
cord-280878-1kt51viz	125	44	et	et	NNP
cord-280878-1kt51viz	125	45	al	al	NNP
cord-280878-1kt51viz	125	46	.	.	NNP
cord-280878-1kt51viz	125	47	,	,	,
cord-280878-1kt51viz	125	48	2014	2014	CD
cord-280878-1kt51viz	125	49	)	)	-RRB-
cord-280878-1kt51viz	125	50	.	.	.
cord-280878-1kt51viz	126	1	The	the	DT
cord-280878-1kt51viz	126	2	inhibitory	inhibitory	JJ
cord-280878-1kt51viz	126	3	activity	activity	NN
cord-280878-1kt51viz	126	4	of	of	IN
cord-280878-1kt51viz	126	5	the	the	DT
cord-280878-1kt51viz	126	6	compounds	compound	NNS
cord-280878-1kt51viz	126	7	was	be	VBD
cord-280878-1kt51viz	126	8	tested	test	VBN
cord-280878-1kt51viz	126	9	on	on	IN
cord-280878-1kt51viz	126	10	AM2	am2	JJ
cord-280878-1kt51viz	126	11	channels	channel	NNS
cord-280878-1kt51viz	126	12	expressed	express	VBN
cord-280878-1kt51viz	126	13	in	in	IN
cord-280878-1kt51viz	126	14	Xenopus	Xenopus	NNP
cord-280878-1kt51viz	126	15	laevis	laevi	NNS
cord-280878-1kt51viz	126	16	oocytes	oocyte	NNS
cord-280878-1kt51viz	126	17	using	use	VBG
cord-280878-1kt51viz	126	18	the	the	DT
cord-280878-1kt51viz	126	19	two	two	CD
cord-280878-1kt51viz	126	20	-	-	HYPH
cord-280878-1kt51viz	126	21	electrode	electrode	NN
cord-280878-1kt51viz	126	22	voltage	voltage	NN
cord-280878-1kt51viz	126	23	clamp	clamp	NN
cord-280878-1kt51viz	126	24	(	(	-LRB-
cord-280878-1kt51viz	126	25	TEVC	TEVC	NNP
cord-280878-1kt51viz	126	26	)	)	-RRB-
cord-280878-1kt51viz	126	27	technique	technique	NN
cord-280878-1kt51viz	126	28	,	,	,
cord-280878-1kt51viz	126	29	but	but	CC
cord-280878-1kt51viz	126	30	most	most	JJS
cord-280878-1kt51viz	126	31	of	of	IN
cord-280878-1kt51viz	126	32	the	the	DT
cord-280878-1kt51viz	126	33	compounds	compound	NNS
cord-280878-1kt51viz	126	34	were	be	VBD
cord-280878-1kt51viz	126	35	cytotoxic	cytotoxic	JJ
cord-280878-1kt51viz	126	36	(	(	-LRB-
cord-280878-1kt51viz	126	37	more	more	JJR
cord-280878-1kt51viz	126	38	than	than	IN
cord-280878-1kt51viz	126	39	Amt	Amt	NNP
cord-280878-1kt51viz	126	40	and	and	CC
cord-280878-1kt51viz	126	41	Rim	Rim	NNP
cord-280878-1kt51viz	126	42	)	)	-RRB-
cord-280878-1kt51viz	126	43	,	,	,
cord-280878-1kt51viz	126	44	as	as	IN
cord-280878-1kt51viz	126	45	tested	test	VBN
cord-280878-1kt51viz	126	46	in	in	IN
cord-280878-1kt51viz	126	47	cell	cell	NN
cord-280878-1kt51viz	126	48	-	-	HYPH
cord-280878-1kt51viz	126	49	based	base	VBN
cord-280878-1kt51viz	126	50	antiviral	antiviral	JJ
cord-280878-1kt51viz	126	51	plaque	plaque	NN
cord-280878-1kt51viz	126	52	reduction	reduction	NN
cord-280878-1kt51viz	126	53	assays	assay	NNS
cord-280878-1kt51viz	126	54	.	.	.
cord-280878-1kt51viz	127	1	Therefore	therefore	RB
cord-280878-1kt51viz	127	2	,	,	,
cord-280878-1kt51viz	127	3	despite	despite	IN
cord-280878-1kt51viz	127	4	the	the	DT
cord-280878-1kt51viz	127	5	encouraging	encourage	VBG
cord-280878-1kt51viz	127	6	results	result	NNS
cord-280878-1kt51viz	127	7	obtained	obtain	VBN
cord-280878-1kt51viz	127	8	in	in	IN
cord-280878-1kt51viz	127	9	vitro	vitro	FW
cord-280878-1kt51viz	127	10	,	,	,
cord-280878-1kt51viz	127	11	the	the	DT
cord-280878-1kt51viz	127	12	toxic	toxic	JJ
cord-280878-1kt51viz	127	13	properties	property	NNS
cord-280878-1kt51viz	127	14	of	of	IN
cord-280878-1kt51viz	127	15	these	these	DT
cord-280878-1kt51viz	127	16	compounds	compound	NNS
cord-280878-1kt51viz	127	17	still	still	RB
cord-280878-1kt51viz	127	18	hinder	hinder	VBP
cord-280878-1kt51viz	127	19	their	-PRON-	PRP$
cord-280878-1kt51viz	127	20	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	127	21	potential	potential	NN
cord-280878-1kt51viz	127	22	.	.	.
cord-280878-1kt51viz	128	1	The	the	DT
cord-280878-1kt51viz	128	2	spiro	spiro	NNP
cord-280878-1kt51viz	128	3	-	-	HYPH
cord-280878-1kt51viz	128	4	piperidine	piperidine	NNP
cord-280878-1kt51viz	128	5	inspired	inspire	VBD
cord-280878-1kt51viz	128	6	the	the	DT
cord-280878-1kt51viz	128	7	generation	generation	NN
cord-280878-1kt51viz	128	8	of	of	IN
cord-280878-1kt51viz	128	9	another	another	DT
cord-280878-1kt51viz	128	10	compound	compound	NN
cord-280878-1kt51viz	128	11	(	(	-LRB-
cord-280878-1kt51viz	128	12	Fig	Fig	NNP
cord-280878-1kt51viz	128	13	.	.	.
cord-280878-1kt51viz	128	14	3C	3C	NNP
cord-280878-1kt51viz	128	15	)	)	-RRB-
cord-280878-1kt51viz	128	16	that	that	WDT
cord-280878-1kt51viz	128	17	could	could	MD
cord-280878-1kt51viz	128	18	inhibit	inhibit	VB
cord-280878-1kt51viz	128	19	not	not	RB
cord-280878-1kt51viz	128	20	just	just	RB
cord-280878-1kt51viz	128	21	the	the	DT
cord-280878-1kt51viz	128	22	WT	WT	NNP
cord-280878-1kt51viz	128	23	AM2	AM2	NNP
cord-280878-1kt51viz	128	24	(	(	-LRB-
cord-280878-1kt51viz	128	25	IC	IC	NNP
cord-280878-1kt51viz	128	26	50	50	CD
cord-280878-1kt51viz	128	27	¼	¼	CD
cord-280878-1kt51viz	128	28	18	18	CD
cord-280878-1kt51viz	129	1	μM	μM	NNP
cord-280878-1kt51viz	129	2	)	)	-RRB-
cord-280878-1kt51viz	130	1	but	but	CC
cord-280878-1kt51viz	130	2	also	also	RB
cord-280878-1kt51viz	130	3	mutants	mutant	VBZ
cord-280878-1kt51viz	130	4	L26F	l26f	XX
cord-280878-1kt51viz	131	1	(	(	-LRB-
cord-280878-1kt51viz	131	2	IC	IC	NNP
cord-280878-1kt51viz	131	3	50	50	CD
cord-280878-1kt51viz	131	4	¼	¼	CD
cord-280878-1kt51viz	131	5	6	6	CD
cord-280878-1kt51viz	132	1	μM	μM	NNP
cord-280878-1kt51viz	132	2	)	)	-RRB-
cord-280878-1kt51viz	132	3	and	and	CC
cord-280878-1kt51viz	132	4	V27A	V27A	NNP
cord-280878-1kt51viz	132	5	(	(	-LRB-
cord-280878-1kt51viz	132	6	IC	IC	NNP
cord-280878-1kt51viz	132	7	50	50	CD
cord-280878-1kt51viz	132	8	¼	¼	CD
cord-280878-1kt51viz	132	9	0.3	0.3	CD
cord-280878-1kt51viz	132	10	μM	μm	CD
cord-280878-1kt51viz	132	11	)	)	-RRB-
cord-280878-1kt51viz	133	1	(	(	-LRB-
cord-280878-1kt51viz	133	2	Wang	Wang	NNP
cord-280878-1kt51viz	133	3	,	,	,
cord-280878-1kt51viz	133	4	Ma	Ma	NNP
cord-280878-1kt51viz	133	5	,	,	,
cord-280878-1kt51viz	133	6	Fiorin	Fiorin	NNP
cord-280878-1kt51viz	133	7	,	,	,
cord-280878-1kt51viz	133	8	et	et	NNP
cord-280878-1kt51viz	133	9	al	al	NNP
cord-280878-1kt51viz	133	10	.	.	NNP
cord-280878-1kt51viz	133	11	,	,	,
cord-280878-1kt51viz	133	12	2011	2011	CD
cord-280878-1kt51viz	133	13	)	)	-RRB-
cord-280878-1kt51viz	133	14	.	.	.
cord-280878-1kt51viz	134	1	Direct	direct	JJ
cord-280878-1kt51viz	134	2	interaction	interaction	NN
cord-280878-1kt51viz	134	3	of	of	IN
cord-280878-1kt51viz	134	4	this	this	DT
cord-280878-1kt51viz	134	5	compound	compound	NN
cord-280878-1kt51viz	134	6	with	with	IN
cord-280878-1kt51viz	134	7	the	the	DT
cord-280878-1kt51viz	134	8	V27A	V27A	NNP
cord-280878-1kt51viz	134	9	mutant	mutant	NN
cord-280878-1kt51viz	134	10	was	be	VBD
cord-280878-1kt51viz	134	11	assessed	assess	VBN
cord-280878-1kt51viz	134	12	by	by	IN
cord-280878-1kt51viz	134	13	solid	solid	JJ
cord-280878-1kt51viz	134	14	-	-	HYPH
cord-280878-1kt51viz	134	15	state	state	NN
cord-280878-1kt51viz	134	16	NMR	nmr	NN
cord-280878-1kt51viz	134	17	,	,	,
cord-280878-1kt51viz	134	18	and	and	CC
cord-280878-1kt51viz	134	19	inhibition	inhibition	NN
cord-280878-1kt51viz	134	20	was	be	VBD
cord-280878-1kt51viz	134	21	further	further	RB
cord-280878-1kt51viz	134	22	demonstrated	demonstrate	VBN
cord-280878-1kt51viz	134	23	in	in	IN
cord-280878-1kt51viz	134	24	plaque	plaque	NN
cord-280878-1kt51viz	134	25	reduction	reduction	NN
cord-280878-1kt51viz	134	26	assays	assay	NNS
cord-280878-1kt51viz	134	27	.	.	.
cord-280878-1kt51viz	135	1	This	this	DT
cord-280878-1kt51viz	135	2	compound	compound	NN
cord-280878-1kt51viz	135	3	,	,	,
cord-280878-1kt51viz	135	4	however	however	RB
cord-280878-1kt51viz	135	5	,	,	,
cord-280878-1kt51viz	135	6	was	be	VBD
cord-280878-1kt51viz	135	7	inactive	inactive	JJ
cord-280878-1kt51viz	135	8	against	against	IN
cord-280878-1kt51viz	135	9	the	the	DT
cord-280878-1kt51viz	135	10	S31N	S31N	NNP
cord-280878-1kt51viz	135	11	mutant	mutant	NN
cord-280878-1kt51viz	135	12	.	.	.
cord-280878-1kt51viz	136	1	Such	such	JJ
cord-280878-1kt51viz	136	2	observation	observation	NN
cord-280878-1kt51viz	136	3	was	be	VBD
cord-280878-1kt51viz	136	4	rationalized	rationalize	VBN
cord-280878-1kt51viz	136	5	by	by	IN
cord-280878-1kt51viz	136	6	the	the	DT
cord-280878-1kt51viz	136	7	fact	fact	NN
cord-280878-1kt51viz	136	8	that	that	IN
cord-280878-1kt51viz	136	9	the	the	DT
cord-280878-1kt51viz	136	10	S31N	S31N	NNP
cord-280878-1kt51viz	136	11	mutant	mutant	NN
cord-280878-1kt51viz	136	12	is	be	VBZ
cord-280878-1kt51viz	136	13	more	more	RBR
cord-280878-1kt51viz	136	14	dynamic	dynamic	JJ
cord-280878-1kt51viz	136	15	and	and	CC
cord-280878-1kt51viz	136	16	hydrated	hydrated	JJ
cord-280878-1kt51viz	136	17	in	in	IN
cord-280878-1kt51viz	136	18	the	the	DT
cord-280878-1kt51viz	136	19	pore	pore	NN
cord-280878-1kt51viz	136	20	than	than	IN
cord-280878-1kt51viz	136	21	the	the	DT
cord-280878-1kt51viz	136	22	corresponding	correspond	VBG
cord-280878-1kt51viz	136	23	WT	WT	NNP
cord-280878-1kt51viz	136	24	protein	protein	NN
cord-280878-1kt51viz	136	25	,	,	,
cord-280878-1kt51viz	136	26	as	as	IN
cord-280878-1kt51viz	136	27	shown	show	VBN
cord-280878-1kt51viz	136	28	by	by	IN
cord-280878-1kt51viz	136	29	NMR	NMR	NNP
cord-280878-1kt51viz	136	30	studies	study	NNS
cord-280878-1kt51viz	136	31	.	.	.
cord-280878-1kt51viz	137	1	This	this	DT
cord-280878-1kt51viz	137	2	lead	lead	NN
cord-280878-1kt51viz	137	3	to	to	IN
cord-280878-1kt51viz	137	4	a	a	DT
cord-280878-1kt51viz	137	5	disruption	disruption	NN
cord-280878-1kt51viz	137	6	in	in	IN
cord-280878-1kt51viz	137	7	the	the	DT
cord-280878-1kt51viz	137	8	size	size	NN
cord-280878-1kt51viz	137	9	and	and	CC
cord-280878-1kt51viz	137	10	polarity	polarity	NN
cord-280878-1kt51viz	137	11	of	of	IN
cord-280878-1kt51viz	137	12	the	the	DT
cord-280878-1kt51viz	137	13	pore	pore	NN
cord-280878-1kt51viz	137	14	in	in	IN
cord-280878-1kt51viz	137	15	precisely	precisely	RB
cord-280878-1kt51viz	137	16	the	the	DT
cord-280878-1kt51viz	137	17	region	region	NN
cord-280878-1kt51viz	137	18	that	that	WDT
cord-280878-1kt51viz	137	19	accommodates	accommodate	VBZ
cord-280878-1kt51viz	137	20	the	the	DT
cord-280878-1kt51viz	137	21	adamantane	adamantane	NNP
cord-280878-1kt51viz	137	22	group	group	NN
cord-280878-1kt51viz	137	23	,	,	,
cord-280878-1kt51viz	137	24	thereby	thereby	RB
cord-280878-1kt51viz	137	25	hampering	hamper	VBG
cord-280878-1kt51viz	137	26	the	the	DT
cord-280878-1kt51viz	137	27	discovery	discovery	NN
cord-280878-1kt51viz	137	28	of	of	IN
cord-280878-1kt51viz	137	29	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	137	30	of	of	IN
cord-280878-1kt51viz	137	31	S31N.	s31n.	CD
cord-280878-1kt51viz	138	1	This	this	DT
cord-280878-1kt51viz	138	2	led	lead	VBD
cord-280878-1kt51viz	138	3	to	to	IN
cord-280878-1kt51viz	138	4	attempts	attempt	NNS
cord-280878-1kt51viz	138	5	to	to	TO
cord-280878-1kt51viz	138	6	increase	increase	VB
cord-280878-1kt51viz	138	7	the	the	DT
cord-280878-1kt51viz	138	8	polarity	polarity	NN
cord-280878-1kt51viz	138	9	or	or	CC
cord-280878-1kt51viz	138	10	the	the	DT
cord-280878-1kt51viz	138	11	dimensions	dimension	NNS
cord-280878-1kt51viz	138	12	of	of	IN
cord-280878-1kt51viz	138	13	the	the	DT
cord-280878-1kt51viz	138	14	adamantane	adamantane	NNP
cord-280878-1kt51viz	138	15	core	core	NN
cord-280878-1kt51viz	138	16	in	in	IN
cord-280878-1kt51viz	138	17	order	order	NN
cord-280878-1kt51viz	138	18	to	to	TO
cord-280878-1kt51viz	138	19	capture	capture	VB
cord-280878-1kt51viz	138	20	more	more	JJR
cord-280878-1kt51viz	138	21	interactions	interaction	NNS
cord-280878-1kt51viz	138	22	with	with	IN
cord-280878-1kt51viz	138	23	the	the	DT
cord-280878-1kt51viz	138	24	backbone	backbone	NN
cord-280878-1kt51viz	138	25	of	of	IN
cord-280878-1kt51viz	138	26	the	the	DT
cord-280878-1kt51viz	138	27	channel	channel	NN
cord-280878-1kt51viz	138	28	.	.	.
cord-280878-1kt51viz	139	1	A	a	DT
cord-280878-1kt51viz	139	2	variety	variety	NN
cord-280878-1kt51viz	139	3	of	of	IN
cord-280878-1kt51viz	139	4	scaffolds	scaffold	NNS
cord-280878-1kt51viz	139	5	have	have	VBP
cord-280878-1kt51viz	139	6	been	be	VBN
cord-280878-1kt51viz	139	7	used	use	VBN
cord-280878-1kt51viz	139	8	to	to	TO
cord-280878-1kt51viz	139	9	substitute	substitute	VB
cord-280878-1kt51viz	139	10	for	for	IN
cord-280878-1kt51viz	139	11	the	the	DT
cord-280878-1kt51viz	139	12	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	139	13	adamantane	adamantane	NNP
cord-280878-1kt51viz	139	14	group	group	NN
cord-280878-1kt51viz	139	15	(	(	-LRB-
cord-280878-1kt51viz	139	16	Hu	Hu	NNP
cord-280878-1kt51viz	139	17	et	et	FW
cord-280878-1kt51viz	139	18	al	al	NNP
cord-280878-1kt51viz	139	19	.	.	NNP
cord-280878-1kt51viz	139	20	,	,	,
cord-280878-1kt51viz	139	21	2010	2010	CD
cord-280878-1kt51viz	139	22	;	;	:
cord-280878-1kt51viz	139	23	Wang	Wang	NNP
cord-280878-1kt51viz	139	24	,	,	,
cord-280878-1kt51viz	139	25	Ma	Ma	NNP
cord-280878-1kt51viz	139	26	,	,	,
cord-280878-1kt51viz	139	27	Balannik	Balannik	NNP
cord-280878-1kt51viz	139	28	,	,	,
cord-280878-1kt51viz	139	29	et	et	NNP
cord-280878-1kt51viz	139	30	al	al	NNP
cord-280878-1kt51viz	139	31	.	.	NNP
cord-280878-1kt51viz	139	32	,	,	,
cord-280878-1kt51viz	139	33	2011	2011	CD
cord-280878-1kt51viz	139	34	)	)	-RRB-
cord-280878-1kt51viz	139	35	.	.	.
cord-280878-1kt51viz	140	1	These	these	DT
cord-280878-1kt51viz	140	2	compounds	compound	NNS
cord-280878-1kt51viz	140	3	showed	show	VBD
cord-280878-1kt51viz	140	4	excellent	excellent	JJ
cord-280878-1kt51viz	140	5	activity	activity	NN
cord-280878-1kt51viz	140	6	against	against	IN
cord-280878-1kt51viz	140	7	the	the	DT
cord-280878-1kt51viz	140	8	WT	WT	NNP
cord-280878-1kt51viz	140	9	AM2	AM2	NNP
cord-280878-1kt51viz	140	10	,	,	,
cord-280878-1kt51viz	140	11	and	and	CC
cord-280878-1kt51viz	140	12	some	some	DT
cord-280878-1kt51viz	140	13	were	be	VBD
cord-280878-1kt51viz	140	14	highly	highly	RB
cord-280878-1kt51viz	140	15	active	active	JJ
cord-280878-1kt51viz	140	16	against	against	IN
cord-280878-1kt51viz	140	17	V27A	V27A	NNS
cord-280878-1kt51viz	140	18	and	and	CC
cord-280878-1kt51viz	140	19	L26F	L26F	NNP
cord-280878-1kt51viz	140	20	(	(	-LRB-
cord-280878-1kt51viz	140	21	Wang	Wang	NNP
cord-280878-1kt51viz	140	22	,	,	,
cord-280878-1kt51viz	140	23	Ma	Ma	NNP
cord-280878-1kt51viz	140	24	,	,	,
cord-280878-1kt51viz	140	25	Fiorin	Fiorin	NNP
cord-280878-1kt51viz	140	26	,	,	,
cord-280878-1kt51viz	140	27	et	et	NNP
cord-280878-1kt51viz	140	28	al	al	NNP
cord-280878-1kt51viz	140	29	.	.	NNP
cord-280878-1kt51viz	140	30	,	,	,
cord-280878-1kt51viz	140	31	2011	2011	CD
cord-280878-1kt51viz	140	32	)	)	-RRB-
cord-280878-1kt51viz	140	33	.	.	.
cord-280878-1kt51viz	141	1	However	however	RB
cord-280878-1kt51viz	141	2	,	,	,
cord-280878-1kt51viz	141	3	none	none	NN
cord-280878-1kt51viz	141	4	was	be	VBD
cord-280878-1kt51viz	141	5	better	well	JJR
cord-280878-1kt51viz	141	6	than	than	IN
cord-280878-1kt51viz	141	7	Amt	Amt	NNP
cord-280878-1kt51viz	141	8	against	against	IN
cord-280878-1kt51viz	141	9	S31N.	S31N.	-RRB-
cord-280878-1kt51viz	141	10	Attempts	attempt	NNS
cord-280878-1kt51viz	141	11	to	to	TO
cord-280878-1kt51viz	141	12	introduce	introduce	VB
cord-280878-1kt51viz	141	13	additional	additional	JJ
cord-280878-1kt51viz	141	14	groups	group	NNS
cord-280878-1kt51viz	141	15	to	to	IN
cord-280878-1kt51viz	141	16	the	the	DT
cord-280878-1kt51viz	141	17	amine	amine	NN
cord-280878-1kt51viz	141	18	to	to	TO
cord-280878-1kt51viz	141	19	enhance	enhance	VB
cord-280878-1kt51viz	141	20	affinity	affinity	NN
cord-280878-1kt51viz	141	21	for	for	IN
cord-280878-1kt51viz	141	22	both	both	CC
cord-280878-1kt51viz	141	23	S31N	S31N	NNP
cord-280878-1kt51viz	141	24	and	and	CC
cord-280878-1kt51viz	141	25	WT	WT	NNP
cord-280878-1kt51viz	141	26	via	via	IN
cord-280878-1kt51viz	141	27	additional	additional	JJ
cord-280878-1kt51viz	141	28	electrostatic	electrostatic	JJ
cord-280878-1kt51viz	141	29	interactions	interaction	NNS
cord-280878-1kt51viz	141	30	led	lead	VBN
cord-280878-1kt51viz	141	31	to	to	IN
cord-280878-1kt51viz	141	32	the	the	DT
cord-280878-1kt51viz	141	33	discovery	discovery	NN
cord-280878-1kt51viz	141	34	of	of	IN
cord-280878-1kt51viz	141	35	benzyl	benzyl	NN
cord-280878-1kt51viz	141	36	-	-	HYPH
cord-280878-1kt51viz	141	37	substituted	substitute	VBN
cord-280878-1kt51viz	141	38	amantadine	amantadine	NNP
cord-280878-1kt51viz	141	39	derivatives	derivative	NNS
cord-280878-1kt51viz	141	40	(	(	-LRB-
cord-280878-1kt51viz	141	41	Fig	Fig	NNP
cord-280878-1kt51viz	141	42	.	.	.
cord-280878-1kt51viz	141	43	3D	3D	NNP
cord-280878-1kt51viz	141	44	)	)	-RRB-
cord-280878-1kt51viz	141	45	as	as	IN
cord-280878-1kt51viz	141	46	dual	dual	JJ
cord-280878-1kt51viz	141	47	WT	WT	NNP
cord-280878-1kt51viz	141	48	and	and	CC
cord-280878-1kt51viz	141	49	S31N	S31N	NNP
cord-280878-1kt51viz	141	50	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	141	51	with	with	IN
cord-280878-1kt51viz	141	52	IC	IC	NNP
cord-280878-1kt51viz	141	53	50	50	CD
cord-280878-1kt51viz	141	54	of	of	IN
cord-280878-1kt51viz	141	55	35	35	CD
cord-280878-1kt51viz	141	56	and	and	CC
cord-280878-1kt51viz	141	57	59	59	CD
cord-280878-1kt51viz	141	58	μM	μm	NN
cord-280878-1kt51viz	141	59	for	for	IN
cord-280878-1kt51viz	141	60	S31N	S31N	NNP
cord-280878-1kt51viz	141	61	and	and	CC
cord-280878-1kt51viz	141	62	WT	WT	NNP
cord-280878-1kt51viz	141	63	,	,	,
cord-280878-1kt51viz	141	64	respectively	respectively	RB
cord-280878-1kt51viz	141	65	.	.	.
cord-280878-1kt51viz	142	1	The	the	DT
cord-280878-1kt51viz	142	2	DeGrado	DeGrado	NNP
cord-280878-1kt51viz	142	3	group	group	NN
cord-280878-1kt51viz	142	4	later	later	RB
cord-280878-1kt51viz	142	5	discovered	discover	VBD
cord-280878-1kt51viz	142	6	small	small	JJ
cord-280878-1kt51viz	142	7	-	-	HYPH
cord-280878-1kt51viz	142	8	molecule	molecule	NN
cord-280878-1kt51viz	142	9	drugs	drug	NNS
cord-280878-1kt51viz	142	10	,	,	,
cord-280878-1kt51viz	142	11	eg	eg	XX
cord-280878-1kt51viz	142	12	,	,	,
cord-280878-1kt51viz	142	13	M2WJ332	M2WJ332	NNP
cord-280878-1kt51viz	142	14	,	,	,
cord-280878-1kt51viz	142	15	that	that	WDT
cord-280878-1kt51viz	142	16	locked	lock	VBD
cord-280878-1kt51viz	142	17	the	the	DT
cord-280878-1kt51viz	142	18	dynamic	dynamic	JJ
cord-280878-1kt51viz	142	19	S31N	S31N	NNP
cord-280878-1kt51viz	142	20	mutant	mutant	JJ
cord-280878-1kt51viz	142	21	into	into	IN
cord-280878-1kt51viz	142	22	a	a	DT
cord-280878-1kt51viz	142	23	well	well	RB
cord-280878-1kt51viz	142	24	-	-	HYPH
cord-280878-1kt51viz	142	25	defined	define	VBN
cord-280878-1kt51viz	142	26	conformation	conformation	NN
cord-280878-1kt51viz	142	27	,	,	,
cord-280878-1kt51viz	142	28	enabling	enable	VBG
cord-280878-1kt51viz	142	29	high	high	JJ
cord-280878-1kt51viz	142	30	-	-	HYPH
cord-280878-1kt51viz	142	31	resolution	resolution	NN
cord-280878-1kt51viz	142	32	structure	structure	NN
cord-280878-1kt51viz	142	33	determination	determination	NN
cord-280878-1kt51viz	142	34	by	by	IN
cord-280878-1kt51viz	142	35	solution	solution	NN
cord-280878-1kt51viz	142	36	NMR	NMR	NNP
cord-280878-1kt51viz	142	37	that	that	WDT
cord-280878-1kt51viz	142	38	showed	show	VBD
cord-280878-1kt51viz	142	39	the	the	DT
cord-280878-1kt51viz	142	40	drug	drug	NN
cord-280878-1kt51viz	142	41	bound	bind	VBN
cord-280878-1kt51viz	142	42	in	in	IN
cord-280878-1kt51viz	142	43	the	the	DT
cord-280878-1kt51viz	142	44	homotetrameric	homotetrameric	NNP
cord-280878-1kt51viz	142	45	channel	channel	NN
cord-280878-1kt51viz	142	46	,	,	,
cord-280878-1kt51viz	142	47	threaded	thread	VBN
cord-280878-1kt51viz	142	48	between	between	IN
cord-280878-1kt51viz	142	49	the	the	DT
cord-280878-1kt51viz	142	50	side	side	NN
cord-280878-1kt51viz	142	51	chains	chain	NNS
cord-280878-1kt51viz	142	52	of	of	IN
cord-280878-1kt51viz	142	53	Asn-31	Asn-31	NNP
cord-280878-1kt51viz	142	54	.	.	.
cord-280878-1kt51viz	143	1	These	these	DT
cord-280878-1kt51viz	143	2	compounds	compound	NNS
cord-280878-1kt51viz	143	3	were	be	VBD
cord-280878-1kt51viz	143	4	formed	form	VBN
cord-280878-1kt51viz	143	5	by	by	IN
cord-280878-1kt51viz	143	6	conjugation	conjugation	NN
cord-280878-1kt51viz	143	7	of	of	IN
cord-280878-1kt51viz	143	8	a	a	DT
cord-280878-1kt51viz	143	9	-	-	HYPH
cord-280878-1kt51viz	143	10	CH2-heteroaryl	ch2-heteroaryl	NN
cord-280878-1kt51viz	143	11	group	group	NN
cord-280878-1kt51viz	143	12	to	to	IN
cord-280878-1kt51viz	143	13	the	the	DT
cord-280878-1kt51viz	143	14	amine	amine	NN
cord-280878-1kt51viz	143	15	of	of	IN
cord-280878-1kt51viz	143	16	Amt	Amt	NNP
cord-280878-1kt51viz	143	17	(	(	-LRB-
cord-280878-1kt51viz	143	18	Fig	Fig	NNP
cord-280878-1kt51viz	143	19	.	.	.
cord-280878-1kt51viz	143	20	3E	3E	NNP
cord-280878-1kt51viz	143	21	and	and	CC
cord-280878-1kt51viz	143	22	F	F	NNP
cord-280878-1kt51viz	143	23	,	,	,
cord-280878-1kt51viz	143	24	IC	IC	NNP
cord-280878-1kt51viz	143	25	50	50	CD
cord-280878-1kt51viz	143	26	of	of	IN
cord-280878-1kt51viz	143	27	16	16	CD
cord-280878-1kt51viz	143	28	μM	μm	CD
cord-280878-1kt51viz	143	29	)	)	-RRB-
cord-280878-1kt51viz	143	30	and	and	CC
cord-280878-1kt51viz	143	31	inhibited	inhibit	VBN
cord-280878-1kt51viz	143	32	S31N	S31N	NNP
cord-280878-1kt51viz	143	33	with	with	IN
cord-280878-1kt51viz	143	34	potencies	potency	NNS
cord-280878-1kt51viz	143	35	greater	great	JJR
cord-280878-1kt51viz	143	36	than	than	IN
cord-280878-1kt51viz	143	37	Amt	Amt	NNP
cord-280878-1kt51viz	143	38	against	against	IN
cord-280878-1kt51viz	143	39	AM2	AM2	NNP
cord-280878-1kt51viz	143	40	.	.	.
cord-280878-1kt51viz	144	1	The	the	DT
cord-280878-1kt51viz	144	2	charged	charge	VBN
cord-280878-1kt51viz	144	3	ammonium	ammonium	NN
cord-280878-1kt51viz	144	4	binds	bind	VBZ
cord-280878-1kt51viz	144	5	as	as	IN
cord-280878-1kt51viz	144	6	a	a	DT
cord-280878-1kt51viz	144	7	hydrate	hydrate	NN
cord-280878-1kt51viz	144	8	to	to	IN
cord-280878-1kt51viz	144	9	one	one	CD
cord-280878-1kt51viz	144	10	of	of	IN
cord-280878-1kt51viz	144	11	three	three	CD
cord-280878-1kt51viz	144	12	sites	site	NNS
cord-280878-1kt51viz	144	13	aligned	align	VBN
cord-280878-1kt51viz	144	14	along	along	IN
cord-280878-1kt51viz	144	15	the	the	DT
cord-280878-1kt51viz	144	16	central	central	JJ
cord-280878-1kt51viz	144	17	cavity	cavity	NN
cord-280878-1kt51viz	144	18	that	that	WDT
cord-280878-1kt51viz	144	19	might	may	MD
cord-280878-1kt51viz	144	20	stabilize	stabilize	VB
cord-280878-1kt51viz	144	21	hydroniumlike	hydroniumlike	NN
cord-280878-1kt51viz	144	22	species	specie	NNS
cord-280878-1kt51viz	144	23	formed	form	VBN
cord-280878-1kt51viz	144	24	as	as	IN
cord-280878-1kt51viz	144	25	protons	proton	NNS
cord-280878-1kt51viz	144	26	diffuse	diffuse	VBP
cord-280878-1kt51viz	144	27	through	through	IN
cord-280878-1kt51viz	144	28	the	the	DT
cord-280878-1kt51viz	144	29	outer	outer	JJ
cord-280878-1kt51viz	144	30	channel	channel	NN
cord-280878-1kt51viz	144	31	to	to	IN
cord-280878-1kt51viz	144	32	the	the	DT
cord-280878-1kt51viz	144	33	proton	proton	NN
cord-280878-1kt51viz	144	34	-	-	HYPH
cord-280878-1kt51viz	144	35	shuttling	shuttle	VBG
cord-280878-1kt51viz	144	36	residue	residue	NN
cord-280878-1kt51viz	144	37	His-37	His-37	NNP
cord-280878-1kt51viz	144	38	near	near	IN
cord-280878-1kt51viz	144	39	the	the	DT
cord-280878-1kt51viz	144	40	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	144	41	end	end	NN
cord-280878-1kt51viz	144	42	of	of	IN
cord-280878-1kt51viz	144	43	the	the	DT
cord-280878-1kt51viz	144	44	channel	channel	NN
cord-280878-1kt51viz	144	45	.	.	.
cord-280878-1kt51viz	145	1	;	;	:
cord-280878-1kt51viz	145	2	(	(	-LRB-
cord-280878-1kt51viz	145	3	E	e	NN
cord-280878-1kt51viz	145	4	and	and	CC
cord-280878-1kt51viz	145	5	F	F	NNP
cord-280878-1kt51viz	145	6	)	)	-RRB-
cord-280878-1kt51viz	145	7	compounds	compound	VBZ
cord-280878-1kt51viz	145	8	with	with	IN
cord-280878-1kt51viz	145	9	IC	IC	NNP
cord-280878-1kt51viz	145	10	50	50	CD
cord-280878-1kt51viz	145	11	of	of	IN
cord-280878-1kt51viz	145	12	$	$	$
cord-280878-1kt51viz	145	13	16	16	CD
cord-280878-1kt51viz	145	14	μM	μm	CD
cord-280878-1kt51viz	146	1	;	;	:
cord-280878-1kt51viz	146	2	(	(	-LRB-
cord-280878-1kt51viz	146	3	G	g	NN
cord-280878-1kt51viz	146	4	)	)	-RRB-
cord-280878-1kt51viz	146	5	compound	compound	NN
cord-280878-1kt51viz	146	6	found	find	VBN
cord-280878-1kt51viz	146	7	in	in	IN
cord-280878-1kt51viz	146	8	Wu	Wu	NNP
cord-280878-1kt51viz	146	9	et	et	NNP
cord-280878-1kt51viz	146	10	al	al	NNP
cord-280878-1kt51viz	146	11	.	.	.
cord-280878-1kt51viz	147	1	(	(	-LRB-
cord-280878-1kt51viz	147	2	2014	2014	CD
cord-280878-1kt51viz	147	3	)	)	-RRB-
cord-280878-1kt51viz	147	4	.	.	.
cord-280878-1kt51viz	148	1	Based	base	VBN
cord-280878-1kt51viz	148	2	on	on	IN
cord-280878-1kt51viz	148	3	structural	structural	JJ
cord-280878-1kt51viz	148	4	and	and	CC
cord-280878-1kt51viz	148	5	molecular	molecular	JJ
cord-280878-1kt51viz	148	6	dynamics	dynamic	NNS
cord-280878-1kt51viz	148	7	data	datum	NNS
cord-280878-1kt51viz	148	8	,	,	,
cord-280878-1kt51viz	148	9	the	the	DT
cord-280878-1kt51viz	148	10	DeGrado	DeGrado	NNP
cord-280878-1kt51viz	148	11	group	group	NN
cord-280878-1kt51viz	148	12	realized	realize	VBD
cord-280878-1kt51viz	148	13	that	that	IN
cord-280878-1kt51viz	148	14	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	148	15	that	that	WDT
cord-280878-1kt51viz	148	16	are	be	VBP
cord-280878-1kt51viz	148	17	active	active	JJ
cord-280878-1kt51viz	148	18	against	against	IN
cord-280878-1kt51viz	148	19	both	both	DT
cord-280878-1kt51viz	148	20	WT	WT	NNP
cord-280878-1kt51viz	148	21	and	and	CC
cord-280878-1kt51viz	148	22	S31N	S31N	NNP
cord-280878-1kt51viz	148	23	channels	channel	NNS
cord-280878-1kt51viz	148	24	bind	bind	VBP
cord-280878-1kt51viz	148	25	in	in	IN
cord-280878-1kt51viz	148	26	opposite	opposite	JJ
cord-280878-1kt51viz	148	27	orientations	orientation	NNS
cord-280878-1kt51viz	148	28	:	:	:
cord-280878-1kt51viz	148	29	the	the	DT
cord-280878-1kt51viz	148	30	aromatic	aromatic	JJ
cord-280878-1kt51viz	148	31	headgroup	headgroup	NN
cord-280878-1kt51viz	148	32	faces	face	NNS
cord-280878-1kt51viz	148	33	toward	toward	IN
cord-280878-1kt51viz	148	34	the	the	DT
cord-280878-1kt51viz	148	35	C	c	NN
cord-280878-1kt51viz	148	36	-	-	HYPH
cord-280878-1kt51viz	148	37	terminus	terminus	NN
cord-280878-1kt51viz	148	38	in	in	IN
cord-280878-1kt51viz	148	39	WT	WT	NNP
cord-280878-1kt51viz	148	40	,	,	,
cord-280878-1kt51viz	148	41	and	and	CC
cord-280878-1kt51viz	148	42	toward	toward	IN
cord-280878-1kt51viz	148	43	the	the	DT
cord-280878-1kt51viz	148	44	N	n	CD
cord-280878-1kt51viz	148	45	-	-	HYPH
cord-280878-1kt51viz	148	46	terminus	terminus	NN
cord-280878-1kt51viz	148	47	in	in	IN
cord-280878-1kt51viz	148	48	S31N.	s31n.	CD
cord-280878-1kt51viz	148	49	Investigation	Investigation	NNP
cord-280878-1kt51viz	148	50	of	of	IN
cord-280878-1kt51viz	148	51	substitutions	substitution	NNS
cord-280878-1kt51viz	148	52	led	lead	VBD
cord-280878-1kt51viz	148	53	to	to	IN
cord-280878-1kt51viz	148	54	the	the	DT
cord-280878-1kt51viz	148	55	identification	identification	NN
cord-280878-1kt51viz	148	56	of	of	IN
cord-280878-1kt51viz	148	57	halide	halide	NN
cord-280878-1kt51viz	148	58	-	-	HYPH
cord-280878-1kt51viz	148	59	substituted	substitute	VBN
cord-280878-1kt51viz	148	60	thiophene	thiophene	NNP
cord-280878-1kt51viz	148	61	compounds	compound	NNS
cord-280878-1kt51viz	148	62	.	.	.
cord-280878-1kt51viz	149	1	The	the	DT
cord-280878-1kt51viz	149	2	most	most	RBS
cord-280878-1kt51viz	149	3	potent	potent	JJ
cord-280878-1kt51viz	149	4	of	of	IN
cord-280878-1kt51viz	149	5	which	which	WDT
cord-280878-1kt51viz	150	1	,	,	,
cord-280878-1kt51viz	150	2	N-[(5-bromothiophen-2-yl	N-[(5-bromothiophen-2-yl	NNP
cord-280878-1kt51viz	150	3	)	)	-RRB-
cord-280878-1kt51viz	150	4	methyl]adamantan-1-amine	methyl]adamantan-1-amine	NN
cord-280878-1kt51viz	150	5	(	(	-LRB-
cord-280878-1kt51viz	150	6	Fig	fig	NN
cord-280878-1kt51viz	150	7	.	.	.
cord-280878-1kt51viz	150	8	3	3	CD
cord-280878-1kt51viz	150	9	G	g	NN
cord-280878-1kt51viz	150	10	)	)	-RRB-
cord-280878-1kt51viz	150	11	,	,	,
cord-280878-1kt51viz	150	12	inhibited	inhibit	VBD
cord-280878-1kt51viz	150	13	both	both	CC
cord-280878-1kt51viz	150	14	WT	WT	NNP
cord-280878-1kt51viz	150	15	and	and	CC
cord-280878-1kt51viz	150	16	S31N	S31N	NNP
cord-280878-1kt51viz	150	17	mutant	mutant	JJ
cord-280878-1kt51viz	150	18	with	with	IN
cord-280878-1kt51viz	150	19	comparable	comparable	JJ
cord-280878-1kt51viz	150	20	affinities	affinity	NNS
cord-280878-1kt51viz	150	21	as	as	IN
cord-280878-1kt51viz	150	22	Amt	Amt	NNP
cord-280878-1kt51viz	150	23	against	against	IN
cord-280878-1kt51viz	150	24	WT	WT	NNP
cord-280878-1kt51viz	151	1	(	(	-LRB-
cord-280878-1kt51viz	151	2	Wu	Wu	NNP
cord-280878-1kt51viz	151	3	et	et	NNP
cord-280878-1kt51viz	151	4	al	al	NNP
cord-280878-1kt51viz	151	5	.	.	NNP
cord-280878-1kt51viz	151	6	,	,	,
cord-280878-1kt51viz	151	7	2014	2014	CD
cord-280878-1kt51viz	151	8	)	)	-RRB-
cord-280878-1kt51viz	151	9	.	.	.
cord-280878-1kt51viz	152	1	It	-PRON-	PRP
cord-280878-1kt51viz	152	2	would	would	MD
cord-280878-1kt51viz	152	3	be	be	VB
cord-280878-1kt51viz	152	4	desirable	desirable	JJ
cord-280878-1kt51viz	152	5	to	to	TO
cord-280878-1kt51viz	152	6	develop	develop	VB
cord-280878-1kt51viz	152	7	the	the	DT
cord-280878-1kt51viz	152	8	same	same	JJ
cord-280878-1kt51viz	152	9	paradigm	paradigm	NN
cord-280878-1kt51viz	152	10	found	find	VBN
cord-280878-1kt51viz	152	11	in	in	IN
cord-280878-1kt51viz	152	12	IAV	IAV	NNP
cord-280878-1kt51viz	152	13	AM2	AM2	NNP
cord-280878-1kt51viz	152	14	and	and	CC
cord-280878-1kt51viz	152	15	their	-PRON-	PRP$
cord-280878-1kt51viz	152	16	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	152	17	for	for	IN
cord-280878-1kt51viz	152	18	other	other	JJ
cord-280878-1kt51viz	152	19	viroporins	viroporin	NNS
cord-280878-1kt51viz	152	20	,	,	,
cord-280878-1kt51viz	152	21	so	so	IN
cord-280878-1kt51viz	152	22	that	that	IN
cord-280878-1kt51viz	152	23	their	-PRON-	PRP$
cord-280878-1kt51viz	152	24	channel	channel	NN
cord-280878-1kt51viz	152	25	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	152	26	can	can	MD
cord-280878-1kt51viz	152	27	be	be	VB
cord-280878-1kt51viz	152	28	validated	validate	VBN
cord-280878-1kt51viz	152	29	.	.	.
cord-280878-1kt51viz	153	1	For	for	IN
cord-280878-1kt51viz	153	2	example	example	NN
cord-280878-1kt51viz	153	3	,	,	,
cord-280878-1kt51viz	153	4	many	many	JJ
cord-280878-1kt51viz	153	5	amantadine	amantadine	NN
cord-280878-1kt51viz	153	6	-	-	HYPH
cord-280878-1kt51viz	153	7	resistant	resistant	JJ
cord-280878-1kt51viz	153	8	influenza	influenza	NN
cord-280878-1kt51viz	153	9	viruses	virus	NNS
cord-280878-1kt51viz	153	10	can	can	MD
cord-280878-1kt51viz	153	11	be	be	VB
cord-280878-1kt51viz	153	12	selected	select	VBN
cord-280878-1kt51viz	153	13	in	in	IN
cord-280878-1kt51viz	153	14	cell	cell	NN
cord-280878-1kt51viz	153	15	culture	culture	NN
cord-280878-1kt51viz	153	16	(	(	-LRB-
cord-280878-1kt51viz	153	17	Grambas	Grambas	NNP
cord-280878-1kt51viz	153	18	,	,	,
cord-280878-1kt51viz	153	19	Bennett	Bennett	NNP
cord-280878-1kt51viz	153	20	,	,	,
cord-280878-1kt51viz	153	21	&	&	CC
cord-280878-1kt51viz	153	22	Hay	Hay	NNP
cord-280878-1kt51viz	153	23	,	,	,
cord-280878-1kt51viz	153	24	1992	1992	CD
cord-280878-1kt51viz	153	25	;	;	:
cord-280878-1kt51viz	153	26	Hay	Hay	NNP
cord-280878-1kt51viz	153	27	et	et	FW
cord-280878-1kt51viz	153	28	al	al	NNP
cord-280878-1kt51viz	153	29	.	.	NNP
cord-280878-1kt51viz	153	30	,	,	,
cord-280878-1kt51viz	153	31	1985	1985	CD
cord-280878-1kt51viz	153	32	)	)	-RRB-
cord-280878-1kt51viz	153	33	,	,	,
cord-280878-1kt51viz	153	34	and	and	CC
cord-280878-1kt51viz	153	35	some	some	DT
cord-280878-1kt51viz	153	36	of	of	IN
cord-280878-1kt51viz	153	37	these	these	DT
cord-280878-1kt51viz	153	38	are	be	VBP
cord-280878-1kt51viz	153	39	also	also	RB
cord-280878-1kt51viz	153	40	found	find	VBN
cord-280878-1kt51viz	153	41	in	in	IN
cord-280878-1kt51viz	153	42	infected	infected	JJ
cord-280878-1kt51viz	153	43	patients	patient	NNS
cord-280878-1kt51viz	153	44	undergoing	undergo	VBG
cord-280878-1kt51viz	153	45	treatment	treatment	NN
cord-280878-1kt51viz	153	46	with	with	IN
cord-280878-1kt51viz	153	47	amantadine	amantadine	NNP
cord-280878-1kt51viz	153	48	(	(	-LRB-
cord-280878-1kt51viz	153	49	Shiraishi	Shiraishi	NNP
cord-280878-1kt51viz	153	50	et	et	NNP
cord-280878-1kt51viz	153	51	al	al	NNP
cord-280878-1kt51viz	153	52	.	.	NNP
cord-280878-1kt51viz	153	53	,	,	,
cord-280878-1kt51viz	153	54	2003	2003	CD
cord-280878-1kt51viz	153	55	)	)	-RRB-
cord-280878-1kt51viz	153	56	.	.	.
cord-280878-1kt51viz	154	1	In	in	IN
cord-280878-1kt51viz	154	2	turn	turn	NN
cord-280878-1kt51viz	154	3	,	,	,
cord-280878-1kt51viz	154	4	engineered	engineer	VBN
cord-280878-1kt51viz	154	5	viruses	virus	NNS
cord-280878-1kt51viz	154	6	harboring	harbor	VBG
cord-280878-1kt51viz	154	7	these	these	DT
cord-280878-1kt51viz	154	8	pore	pore	NN
cord-280878-1kt51viz	154	9	-	-	HYPH
cord-280878-1kt51viz	154	10	lining	lining	NN
cord-280878-1kt51viz	154	11	mutations	mutation	NNS
cord-280878-1kt51viz	154	12	,	,	,
cord-280878-1kt51viz	154	13	while	while	IN
cord-280878-1kt51viz	154	14	competent	competent	JJ
cord-280878-1kt51viz	154	15	to	to	TO
cord-280878-1kt51viz	154	16	replicate	replicate	VB
cord-280878-1kt51viz	154	17	in	in	IN
cord-280878-1kt51viz	154	18	mouse	mouse	NN
cord-280878-1kt51viz	154	19	(	(	-LRB-
cord-280878-1kt51viz	154	20	Abed	Abed	NNP
cord-280878-1kt51viz	154	21	,	,	,
cord-280878-1kt51viz	154	22	Goyette	Goyette	NNP
cord-280878-1kt51viz	154	23	,	,	,
cord-280878-1kt51viz	154	24	&	&	CC
cord-280878-1kt51viz	154	25	Boivin	Boivin	NNP
cord-280878-1kt51viz	154	26	,	,	,
cord-280878-1kt51viz	154	27	2005	2005	CD
cord-280878-1kt51viz	154	28	)	)	-RRB-
cord-280878-1kt51viz	154	29	,	,	,
cord-280878-1kt51viz	154	30	give	give	VBP
cord-280878-1kt51viz	154	31	rise	rise	NN
cord-280878-1kt51viz	154	32	to	to	IN
cord-280878-1kt51viz	154	33	attenuated	attenuated	JJ
cord-280878-1kt51viz	154	34	viruses	virus	NNS
cord-280878-1kt51viz	154	35	that	that	WDT
cord-280878-1kt51viz	154	36	tend	tend	VBP
cord-280878-1kt51viz	154	37	to	to	TO
cord-280878-1kt51viz	154	38	revert	revert	VB
cord-280878-1kt51viz	154	39	to	to	IN
cord-280878-1kt51viz	154	40	the	the	DT
cord-280878-1kt51viz	154	41	WT	WT	NNP
cord-280878-1kt51viz	154	42	in	in	IN
cord-280878-1kt51viz	154	43	the	the	DT
cord-280878-1kt51viz	154	44	absence	absence	NN
cord-280878-1kt51viz	154	45	of	of	IN
cord-280878-1kt51viz	154	46	drug	drug	NN
cord-280878-1kt51viz	154	47	pressure	pressure	NN
cord-280878-1kt51viz	154	48	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	154	49	et	et	FW
cord-280878-1kt51viz	154	50	al	al	NNP
cord-280878-1kt51viz	154	51	.	.	NNP
cord-280878-1kt51viz	154	52	,	,	,
cord-280878-1kt51viz	154	53	2003	2003	CD
cord-280878-1kt51viz	154	54	)	)	-RRB-
cord-280878-1kt51viz	154	55	.	.	.
cord-280878-1kt51viz	155	1	Another	another	DT
cord-280878-1kt51viz	155	2	very	very	RB
cord-280878-1kt51viz	155	3	important	important	JJ
cord-280878-1kt51viz	155	4	viroporin	viroporin	NN
cord-280878-1kt51viz	155	5	is	be	VBZ
cord-280878-1kt51viz	155	6	p7	p7	NN
cord-280878-1kt51viz	155	7	,	,	,
cord-280878-1kt51viz	155	8	found	find	VBN
cord-280878-1kt51viz	155	9	in	in	IN
cord-280878-1kt51viz	155	10	the	the	DT
cord-280878-1kt51viz	155	11	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	155	12	C	C	NNP
cord-280878-1kt51viz	155	13	virus	virus	NN
cord-280878-1kt51viz	155	14	(	(	-LRB-
cord-280878-1kt51viz	155	15	HCV	HCV	NNP
cord-280878-1kt51viz	155	16	)	)	-RRB-
cord-280878-1kt51viz	155	17	,	,	,
cord-280878-1kt51viz	155	18	a	a	DT
cord-280878-1kt51viz	155	19	member	member	NN
cord-280878-1kt51viz	155	20	of	of	IN
cord-280878-1kt51viz	155	21	the	the	DT
cord-280878-1kt51viz	155	22	Flaviviridae	Flaviviridae	NNP
cord-280878-1kt51viz	155	23	family	family	NN
cord-280878-1kt51viz	155	24	that	that	WDT
cord-280878-1kt51viz	155	25	has	have	VBZ
cord-280878-1kt51viz	155	26	six	six	CD
cord-280878-1kt51viz	155	27	genotypes	genotype	NNS
cord-280878-1kt51viz	155	28	(	(	-LRB-
cord-280878-1kt51viz	155	29	GTs	GTs	NNP
cord-280878-1kt51viz	155	30	)	)	-RRB-
cord-280878-1kt51viz	155	31	.	.	.
cord-280878-1kt51viz	156	1	HCV	HCV	NNP
cord-280878-1kt51viz	156	2	is	be	VBZ
cord-280878-1kt51viz	156	3	a	a	DT
cord-280878-1kt51viz	156	4	positive	positive	JJ
cord-280878-1kt51viz	156	5	-	-	HYPH
cord-280878-1kt51viz	156	6	strand	strand	NN
cord-280878-1kt51viz	156	7	RNA	RNA	NNP
cord-280878-1kt51viz	156	8	virus	virus	NN
cord-280878-1kt51viz	156	9	that	that	WDT
cord-280878-1kt51viz	156	10	causes	cause	VBZ
cord-280878-1kt51viz	156	11	severe	severe	JJ
cord-280878-1kt51viz	156	12	liver	liver	NN
cord-280878-1kt51viz	156	13	disease	disease	NN
cord-280878-1kt51viz	156	14	and	and	CC
cord-280878-1kt51viz	156	15	is	be	VBZ
cord-280878-1kt51viz	156	16	the	the	DT
cord-280878-1kt51viz	156	17	major	major	JJ
cord-280878-1kt51viz	156	18	cause	cause	NN
cord-280878-1kt51viz	156	19	of	of	IN
cord-280878-1kt51viz	156	20	hepatocellular	hepatocellular	JJ
cord-280878-1kt51viz	156	21	carcinomas	carcinoma	NNS
cord-280878-1kt51viz	156	22	in	in	IN
cord-280878-1kt51viz	156	23	the	the	DT
cord-280878-1kt51viz	156	24	developed	develop	VBN
cord-280878-1kt51viz	156	25	world	world	NN
cord-280878-1kt51viz	156	26	.	.	.
cord-280878-1kt51viz	157	1	HCV	HCV	NNP
cord-280878-1kt51viz	157	2	has	have	VBZ
cord-280878-1kt51viz	157	3	chronically	chronically	RB
cord-280878-1kt51viz	157	4	infected	infect	VBN
cord-280878-1kt51viz	157	5	170	170	CD
cord-280878-1kt51viz	157	6	million	million	CD
cord-280878-1kt51viz	157	7	people	people	NNS
cord-280878-1kt51viz	157	8	worldwide	worldwide	RB
cord-280878-1kt51viz	157	9	and	and	CC
cord-280878-1kt51viz	157	10	is	be	VBZ
cord-280878-1kt51viz	157	11	responsible	responsible	JJ
cord-280878-1kt51viz	157	12	for	for	IN
cord-280878-1kt51viz	157	13	more	more	JJR
cord-280878-1kt51viz	157	14	than	than	IN
cord-280878-1kt51viz	157	15	300,000	300,000	CD
cord-280878-1kt51viz	157	16	yearly	yearly	JJ
cord-280878-1kt51viz	157	17	deaths	death	NNS
cord-280878-1kt51viz	157	18	,	,	,
cord-280878-1kt51viz	157	19	while	while	IN
cord-280878-1kt51viz	157	20	no	no	DT
cord-280878-1kt51viz	157	21	prophylactic	prophylactic	JJ
cord-280878-1kt51viz	157	22	or	or	CC
cord-280878-1kt51viz	157	23	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	157	24	vaccine	vaccine	NN
cord-280878-1kt51viz	157	25	is	be	VBZ
cord-280878-1kt51viz	157	26	available	available	JJ
cord-280878-1kt51viz	157	27	.	.	.
cord-280878-1kt51viz	158	1	HCV	HCV	NNP
cord-280878-1kt51viz	158	2	infection	infection	NN
cord-280878-1kt51viz	158	3	can	can	MD
cord-280878-1kt51viz	158	4	be	be	VB
cord-280878-1kt51viz	158	5	cured	cure	VBN
cord-280878-1kt51viz	158	6	with	with	IN
cord-280878-1kt51viz	158	7	drugs	drug	NNS
cord-280878-1kt51viz	158	8	targeting	target	VBG
cord-280878-1kt51viz	158	9	viral	viral	JJ
cord-280878-1kt51viz	158	10	enzymes	enzyme	NNS
cord-280878-1kt51viz	158	11	and	and	CC
cord-280878-1kt51viz	158	12	proteins	protein	NNS
cord-280878-1kt51viz	158	13	,	,	,
cord-280878-1kt51viz	158	14	as	as	RB
cord-280878-1kt51viz	158	15	well	well	RB
cord-280878-1kt51viz	158	16	as	as	IN
cord-280878-1kt51viz	158	17	host	host	NN
cord-280878-1kt51viz	158	18	cellular	cellular	JJ
cord-280878-1kt51viz	158	19	proteins	protein	NNS
cord-280878-1kt51viz	158	20	.	.	.
cord-280878-1kt51viz	159	1	One	one	CD
cord-280878-1kt51viz	159	2	host	host	NN
cord-280878-1kt51viz	159	3	-	-	HYPH
cord-280878-1kt51viz	159	4	targeted	target	VBN
cord-280878-1kt51viz	159	5	antiviral	antiviral	JJ
cord-280878-1kt51viz	159	6	agent	agent	NN
cord-280878-1kt51viz	159	7	(	(	-LRB-
cord-280878-1kt51viz	159	8	HTAs	hta	NNS
cord-280878-1kt51viz	159	9	)	)	-RRB-
cord-280878-1kt51viz	159	10	is	be	VBZ
cord-280878-1kt51viz	159	11	the	the	DT
cord-280878-1kt51viz	159	12	type	type	NN
cord-280878-1kt51viz	160	1	I	-PRON-	PRP
cord-280878-1kt51viz	160	2	IFN	IFN	NNP
cord-280878-1kt51viz	160	3	-	-	HYPH
cord-280878-1kt51viz	160	4	α	α	NNP
cord-280878-1kt51viz	160	5	(	(	-LRB-
cord-280878-1kt51viz	160	6	Hoofnagle	Hoofnagle	NNP
cord-280878-1kt51viz	160	7	et	et	NNP
cord-280878-1kt51viz	160	8	al	al	NNP
cord-280878-1kt51viz	160	9	.	.	NNP
cord-280878-1kt51viz	160	10	,	,	,
cord-280878-1kt51viz	160	11	1986	1986	CD
cord-280878-1kt51viz	160	12	)	)	-RRB-
cord-280878-1kt51viz	160	13	,	,	,
cord-280878-1kt51viz	160	14	which	which	WDT
cord-280878-1kt51viz	160	15	exerts	exert	VBZ
cord-280878-1kt51viz	160	16	antiviral	antiviral	JJ
cord-280878-1kt51viz	160	17	activities	activity	NNS
cord-280878-1kt51viz	160	18	against	against	IN
cord-280878-1kt51viz	160	19	both	both	CC
cord-280878-1kt51viz	160	20	RNA	RNA	NNP
cord-280878-1kt51viz	160	21	and	and	CC
cord-280878-1kt51viz	160	22	DNA	dna	NN
cord-280878-1kt51viz	160	23	viruses	virus	NNS
cord-280878-1kt51viz	160	24	through	through	IN
cord-280878-1kt51viz	160	25	IFN	IFN	NNP
cord-280878-1kt51viz	160	26	-	-	HYPH
cord-280878-1kt51viz	160	27	stimulated	stimulate	VBN
cord-280878-1kt51viz	160	28	gene	gene	NN
cord-280878-1kt51viz	160	29	(	(	-LRB-
cord-280878-1kt51viz	160	30	ISG	ISG	NNP
cord-280878-1kt51viz	160	31	)	)	-RRB-
cord-280878-1kt51viz	160	32	products	product	NNS
cord-280878-1kt51viz	160	33	.	.	.
cord-280878-1kt51viz	161	1	Pegylated	pegylated	JJ
cord-280878-1kt51viz	161	2	IFN	IFN	NNP
cord-280878-1kt51viz	161	3	has	have	VBZ
cord-280878-1kt51viz	161	4	been	be	VBN
cord-280878-1kt51viz	161	5	used	use	VBN
cord-280878-1kt51viz	161	6	in	in	IN
cord-280878-1kt51viz	161	7	combination	combination	NN
cord-280878-1kt51viz	161	8	with	with	IN
cord-280878-1kt51viz	161	9	ribavirin	ribavirin	NN
cord-280878-1kt51viz	161	10	(	(	-LRB-
cord-280878-1kt51viz	161	11	RBV	RBV	NNP
cord-280878-1kt51viz	161	12	)	)	-RRB-
cord-280878-1kt51viz	161	13	,	,	,
cord-280878-1kt51viz	161	14	a	a	DT
cord-280878-1kt51viz	161	15	synthetic	synthetic	JJ
cord-280878-1kt51viz	161	16	guanosine	guanosine	NN
cord-280878-1kt51viz	161	17	analogue	analogue	NN
cord-280878-1kt51viz	161	18	(	(	-LRB-
cord-280878-1kt51viz	161	19	Herrmann	Herrmann	NNP
cord-280878-1kt51viz	161	20	,	,	,
cord-280878-1kt51viz	161	21	Lee	Lee	NNP
cord-280878-1kt51viz	161	22	,	,	,
cord-280878-1kt51viz	161	23	Marinos	Marinos	NNP
cord-280878-1kt51viz	161	24	,	,	,
cord-280878-1kt51viz	161	25	Modi	Modi	NNP
cord-280878-1kt51viz	161	26	,	,	,
cord-280878-1kt51viz	161	27	&	&	CC
cord-280878-1kt51viz	161	28	Zeuzem	Zeuzem	NNP
cord-280878-1kt51viz	161	29	,	,	,
cord-280878-1kt51viz	161	30	2003	2003	CD
cord-280878-1kt51viz	161	31	)	)	-RRB-
cord-280878-1kt51viz	161	32	,	,	,
cord-280878-1kt51viz	161	33	but	but	CC
cord-280878-1kt51viz	161	34	this	this	DT
cord-280878-1kt51viz	161	35	antiviral	antiviral	JJ
cord-280878-1kt51viz	161	36	therapy	therapy	NN
cord-280878-1kt51viz	161	37	can	can	MD
cord-280878-1kt51viz	161	38	only	only	RB
cord-280878-1kt51viz	161	39	last	last	VB
cord-280878-1kt51viz	161	40	up	up	IN
cord-280878-1kt51viz	161	41	to	to	IN
cord-280878-1kt51viz	161	42	1	1	CD
cord-280878-1kt51viz	161	43	year	year	NN
cord-280878-1kt51viz	161	44	,	,	,
cord-280878-1kt51viz	161	45	associated	associate	VBN
cord-280878-1kt51viz	161	46	with	with	IN
cord-280878-1kt51viz	161	47	side	side	JJ
cord-280878-1kt51viz	161	48	effects	effect	NNS
cord-280878-1kt51viz	161	49	,	,	,
cord-280878-1kt51viz	161	50	and	and	CC
cord-280878-1kt51viz	161	51	is	be	VBZ
cord-280878-1kt51viz	161	52	not	not	RB
cord-280878-1kt51viz	161	53	always	always	RB
cord-280878-1kt51viz	161	54	effective	effective	JJ
cord-280878-1kt51viz	162	1	(	(	-LRB-
cord-280878-1kt51viz	162	2	Manns	Manns	NNP
cord-280878-1kt51viz	162	3	,	,	,
cord-280878-1kt51viz	162	4	Wedemeyer	Wedemeyer	NNP
cord-280878-1kt51viz	162	5	,	,	,
cord-280878-1kt51viz	162	6	&	&	CC
cord-280878-1kt51viz	162	7	Cornberg	Cornberg	NNP
cord-280878-1kt51viz	162	8	,	,	,
cord-280878-1kt51viz	162	9	2006	2006	CD
cord-280878-1kt51viz	162	10	;	;	:
cord-280878-1kt51viz	162	11	Pawlotsky	Pawlotsky	NNP
cord-280878-1kt51viz	162	12	,	,	,
cord-280878-1kt51viz	162	13	Chevaliez	Chevaliez	NNP
cord-280878-1kt51viz	162	14	,	,	,
cord-280878-1kt51viz	162	15	&	&	CC
cord-280878-1kt51viz	162	16	McHutchison	McHutchison	NNP
cord-280878-1kt51viz	162	17	,	,	,
cord-280878-1kt51viz	162	18	2007	2007	CD
cord-280878-1kt51viz	162	19	)	)	-RRB-
cord-280878-1kt51viz	162	20	.	.	.
cord-280878-1kt51viz	163	1	Other	other	JJ
cord-280878-1kt51viz	163	2	drugs	drug	NNS
cord-280878-1kt51viz	163	3	target	target	VBP
cord-280878-1kt51viz	163	4	HCV	HCV	NNP
cord-280878-1kt51viz	163	5	proteins	protein	NNS
cord-280878-1kt51viz	163	6	with	with	IN
cord-280878-1kt51viz	163	7	high	high	JJ
cord-280878-1kt51viz	163	8	potency	potency	NN
cord-280878-1kt51viz	163	9	,	,	,
cord-280878-1kt51viz	163	10	such	such	JJ
cord-280878-1kt51viz	163	11	as	as	IN
cord-280878-1kt51viz	163	12	those	those	DT
cord-280878-1kt51viz	163	13	against	against	IN
cord-280878-1kt51viz	163	14	the	the	DT
cord-280878-1kt51viz	163	15	HCV	HCV	NNP
cord-280878-1kt51viz	163	16	NS3/4A	ns3/4a	NN
cord-280878-1kt51viz	163	17	protease	protease	NN
cord-280878-1kt51viz	163	18	,	,	,
cord-280878-1kt51viz	163	19	the	the	DT
cord-280878-1kt51viz	163	20	NS5A	NS5A	NNP
cord-280878-1kt51viz	163	21	protein	protein	NN
cord-280878-1kt51viz	163	22	or	or	CC
cord-280878-1kt51viz	163	23	the	the	DT
cord-280878-1kt51viz	163	24	NS5B	NS5B	NNP
cord-280878-1kt51viz	163	25	RNA	RNA	NNP
cord-280878-1kt51viz	163	26	-	-	HYPH
cord-280878-1kt51viz	163	27	dependent	dependent	JJ
cord-280878-1kt51viz	163	28	RNA	RNA	NNP
cord-280878-1kt51viz	163	29	polymerase	polymerase	NN
cord-280878-1kt51viz	163	30	(	(	-LRB-
cord-280878-1kt51viz	163	31	RdRP	rdrp	NN
cord-280878-1kt51viz	163	32	)	)	-RRB-
cord-280878-1kt51viz	164	1	(	(	-LRB-
cord-280878-1kt51viz	164	2	Sulkowski	Sulkowski	NNP
cord-280878-1kt51viz	164	3	et	et	NNP
cord-280878-1kt51viz	164	4	al	al	NNP
cord-280878-1kt51viz	164	5	.	.	NNP
cord-280878-1kt51viz	164	6	,	,	,
cord-280878-1kt51viz	164	7	2014	2014	CD
cord-280878-1kt51viz	164	8	)	)	-RRB-
cord-280878-1kt51viz	165	1	[	[	-LRB-
cord-280878-1kt51viz	165	2	see	see	VB
cord-280878-1kt51viz	165	3	Pawlotsky	Pawlotsky	NNP
cord-280878-1kt51viz	165	4	,	,	,
cord-280878-1kt51viz	165	5	2014	2014	CD
cord-280878-1kt51viz	165	6	;	;	:
cord-280878-1kt51viz	165	7	Schmidt	Schmidt	NNP
cord-280878-1kt51viz	165	8	et	et	NNP
cord-280878-1kt51viz	165	9	al	al	NNP
cord-280878-1kt51viz	165	10	.	.	NNP
cord-280878-1kt51viz	165	11	,	,	,
cord-280878-1kt51viz	165	12	2014	2014	CD
cord-280878-1kt51viz	165	13	,	,	,
cord-280878-1kt51viz	165	14	for	for	IN
cord-280878-1kt51viz	165	15	recent	recent	JJ
cord-280878-1kt51viz	165	16	reviews	review	NNS
cord-280878-1kt51viz	165	17	]	]	-RRB-
cord-280878-1kt51viz	165	18	.	.	.
cord-280878-1kt51viz	166	1	However	however	RB
cord-280878-1kt51viz	166	2	,	,	,
cord-280878-1kt51viz	166	3	drug	drug	NN
cord-280878-1kt51viz	166	4	resistance	resistance	NN
cord-280878-1kt51viz	166	5	creates	create	VBZ
cord-280878-1kt51viz	166	6	a	a	DT
cord-280878-1kt51viz	166	7	burden	burden	NN
cord-280878-1kt51viz	166	8	for	for	IN
cord-280878-1kt51viz	166	9	patients	patient	NNS
cord-280878-1kt51viz	166	10	,	,	,
cord-280878-1kt51viz	166	11	worsened	worsen	VBN
cord-280878-1kt51viz	166	12	by	by	IN
cord-280878-1kt51viz	166	13	the	the	DT
cord-280878-1kt51viz	166	14	rapid	rapid	JJ
cord-280878-1kt51viz	166	15	turnover	turnover	NN
cord-280878-1kt51viz	166	16	of	of	IN
cord-280878-1kt51viz	166	17	HCV	HCV	NNP
cord-280878-1kt51viz	166	18	replication	replication	NN
cord-280878-1kt51viz	166	19	,	,	,
cord-280878-1kt51viz	166	20	which	which	WDT
cord-280878-1kt51viz	166	21	produces	produce	VBZ
cord-280878-1kt51viz	166	22	up	up	IN
cord-280878-1kt51viz	166	23	to	to	TO
cord-280878-1kt51viz	166	24	10	10	CD
cord-280878-1kt51viz	166	25	12	12	CD
cord-280878-1kt51viz	166	26	virions	virion	NNS
cord-280878-1kt51viz	166	27	daily	daily	JJ
cord-280878-1kt51viz	166	28	(	(	-LRB-
cord-280878-1kt51viz	166	29	Neumann	Neumann	NNP
cord-280878-1kt51viz	166	30	et	et	NNP
cord-280878-1kt51viz	166	31	al	al	NNP
cord-280878-1kt51viz	166	32	.	.	NNP
cord-280878-1kt51viz	166	33	,	,	,
cord-280878-1kt51viz	166	34	1998	1998	CD
cord-280878-1kt51viz	166	35	)	)	-RRB-
cord-280878-1kt51viz	166	36	.	.	.
cord-280878-1kt51viz	167	1	This	this	DT
cord-280878-1kt51viz	167	2	is	be	VBZ
cord-280878-1kt51viz	167	3	compounded	compound	VBN
cord-280878-1kt51viz	167	4	by	by	IN
cord-280878-1kt51viz	167	5	the	the	DT
cord-280878-1kt51viz	167	6	error	error	NN
cord-280878-1kt51viz	167	7	-	-	HYPH
cord-280878-1kt51viz	167	8	prone	prone	JJ
cord-280878-1kt51viz	167	9	activity	activity	NN
cord-280878-1kt51viz	167	10	of	of	IN
cord-280878-1kt51viz	167	11	the	the	DT
cord-280878-1kt51viz	167	12	HCV	HCV	NNP
cord-280878-1kt51viz	167	13	RNA	RNA	NNP
cord-280878-1kt51viz	167	14	polymerase	polymerase	NN
cord-280878-1kt51viz	167	15	,	,	,
cord-280878-1kt51viz	167	16	which	which	WDT
cord-280878-1kt51viz	167	17	leads	lead	VBZ
cord-280878-1kt51viz	167	18	to	to	IN
cord-280878-1kt51viz	167	19	the	the	DT
cord-280878-1kt51viz	167	20	high	high	JJ
cord-280878-1kt51viz	167	21	genetic	genetic	JJ
cord-280878-1kt51viz	167	22	diversity	diversity	NN
cord-280878-1kt51viz	167	23	of	of	IN
cord-280878-1kt51viz	167	24	HCV	HCV	NNP
cord-280878-1kt51viz	167	25	and	and	CC
cord-280878-1kt51viz	167	26	the	the	DT
cord-280878-1kt51viz	167	27	formation	formation	NN
cord-280878-1kt51viz	167	28	of	of	IN
cord-280878-1kt51viz	167	29	"	"	``
cord-280878-1kt51viz	167	30	quasi	quasi	JJ
cord-280878-1kt51viz	167	31	-	-	NNS
cord-280878-1kt51viz	167	32	species	specie	NNS
cord-280878-1kt51viz	167	33	.	.	.
cord-280878-1kt51viz	167	34	"	"	''
cord-280878-1kt51viz	168	1	In	in	IN
cord-280878-1kt51viz	168	2	this	this	DT
cord-280878-1kt51viz	168	3	complicated	complicated	JJ
cord-280878-1kt51viz	168	4	context	context	NN
cord-280878-1kt51viz	168	5	,	,	,
cord-280878-1kt51viz	168	6	the	the	DT
cord-280878-1kt51viz	168	7	clinical	clinical	JJ
cord-280878-1kt51viz	168	8	niche	niche	NN
cord-280878-1kt51viz	168	9	of	of	IN
cord-280878-1kt51viz	168	10	p7	p7	NN
cord-280878-1kt51viz	168	11	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	168	12	is	be	VBZ
cord-280878-1kt51viz	168	13	unclear	unclear	JJ
cord-280878-1kt51viz	168	14	.	.	.
cord-280878-1kt51viz	169	1	The	the	DT
cord-280878-1kt51viz	169	2	viroporin	viroporin	NN
cord-280878-1kt51viz	169	3	HCV	HCV	NNP
cord-280878-1kt51viz	169	4	p7	p7	NN
cord-280878-1kt51viz	169	5	is	be	VBZ
cord-280878-1kt51viz	169	6	encoded	encode	VBN
cord-280878-1kt51viz	169	7	within	within	IN
cord-280878-1kt51viz	169	8	a	a	DT
cord-280878-1kt51viz	169	9	single	single	JJ
cord-280878-1kt51viz	169	10	polyprotein	polyprotein	JJ
cord-280878-1kt51viz	169	11	precursor	precursor	NN
cord-280878-1kt51viz	169	12	(	(	-LRB-
cord-280878-1kt51viz	169	13	Simmonds	Simmonds	NNP
cord-280878-1kt51viz	169	14	,	,	,
cord-280878-1kt51viz	169	15	2013	2013	CD
cord-280878-1kt51viz	169	16	)	)	-RRB-
cord-280878-1kt51viz	169	17	processed	process	VBN
cord-280878-1kt51viz	169	18	by	by	IN
cord-280878-1kt51viz	169	19	host	host	NN
cord-280878-1kt51viz	169	20	and	and	CC
cord-280878-1kt51viz	169	21	viral	viral	JJ
cord-280878-1kt51viz	169	22	proteases	protease	NNS
cord-280878-1kt51viz	169	23	(	(	-LRB-
cord-280878-1kt51viz	169	24	Moradpour	Moradpour	NNP
cord-280878-1kt51viz	169	25	&	&	CC
cord-280878-1kt51viz	169	26	Penin	Penin	NNP
cord-280878-1kt51viz	169	27	,	,	,
cord-280878-1kt51viz	169	28	2013	2013	CD
cord-280878-1kt51viz	169	29	)	)	-RRB-
cord-280878-1kt51viz	169	30	.	.	.
cord-280878-1kt51viz	170	1	It	-PRON-	PRP
cord-280878-1kt51viz	170	2	separates	separate	VBZ
cord-280878-1kt51viz	170	3	the	the	DT
cord-280878-1kt51viz	170	4	structural	structural	JJ
cord-280878-1kt51viz	170	5	proteins	protein	NNS
cord-280878-1kt51viz	170	6	(	(	-LRB-
cord-280878-1kt51viz	170	7	core	core	NN
cord-280878-1kt51viz	170	8	and	and	CC
cord-280878-1kt51viz	170	9	envelope	envelope	NN
cord-280878-1kt51viz	170	10	glycoproteins	glycoprotein	NNS
cord-280878-1kt51viz	170	11	E1	e1	NN
cord-280878-1kt51viz	170	12	and	and	CC
cord-280878-1kt51viz	170	13	E2	E2	NNP
cord-280878-1kt51viz	170	14	)	)	-RRB-
cord-280878-1kt51viz	170	15	from	from	IN
cord-280878-1kt51viz	170	16	the	the	DT
cord-280878-1kt51viz	170	17	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	170	18	proteins	protein	NNS
cord-280878-1kt51viz	170	19	NS2	NS2	NNP
cord-280878-1kt51viz	170	20	,	,	,
cord-280878-1kt51viz	170	21	NS3	ns3	RB
cord-280878-1kt51viz	170	22	,	,	,
cord-280878-1kt51viz	170	23	NS4A	NS4A	NNP
cord-280878-1kt51viz	170	24	,	,	,
cord-280878-1kt51viz	170	25	NS4B	NS4B	NNP
cord-280878-1kt51viz	170	26	,	,	,
cord-280878-1kt51viz	170	27	NS5A	NS5A	NNP
cord-280878-1kt51viz	170	28	,	,	,
cord-280878-1kt51viz	170	29	and	and	CC
cord-280878-1kt51viz	170	30	NS5B	ns5b	JJ
cord-280878-1kt51viz	170	31	(	(	-LRB-
cord-280878-1kt51viz	170	32	Lindenbach	Lindenbach	NNP
cord-280878-1kt51viz	170	33	&	&	CC
cord-280878-1kt51viz	170	34	Rice	Rice	NNP
cord-280878-1kt51viz	170	35	,	,	,
cord-280878-1kt51viz	170	36	2005	2005	CD
cord-280878-1kt51viz	170	37	)	)	-RRB-
cord-280878-1kt51viz	170	38	.	.	.
cord-280878-1kt51viz	171	1	p7	p7	NN
cord-280878-1kt51viz	171	2	results	result	VBZ
cord-280878-1kt51viz	171	3	from	from	IN
cord-280878-1kt51viz	171	4	cleavage	cleavage	NN
cord-280878-1kt51viz	171	5	of	of	IN
cord-280878-1kt51viz	171	6	E2-p7-NS2	e2-p7-ns2	NN
cord-280878-1kt51viz	171	7	and	and	CC
cord-280878-1kt51viz	171	8	E2-p7	e2-p7	RB
cord-280878-1kt51viz	171	9	by	by	IN
cord-280878-1kt51viz	171	10	a	a	DT
cord-280878-1kt51viz	171	11	signal	signal	JJ
cord-280878-1kt51viz	171	12	peptidase	peptidase	NN
cord-280878-1kt51viz	171	13	at	at	IN
cord-280878-1kt51viz	171	14	the	the	DT
cord-280878-1kt51viz	171	15	ER	ER	NNP
cord-280878-1kt51viz	172	1	(	(	-LRB-
cord-280878-1kt51viz	172	2	Lin	Lin	NNP
cord-280878-1kt51viz	172	3	,	,	,
cord-280878-1kt51viz	172	4	Lindenbach	Lindenbach	NNP
cord-280878-1kt51viz	172	5	,	,	,
cord-280878-1kt51viz	172	6	Prágai	Prágai	NNP
cord-280878-1kt51viz	172	7	,	,	,
cord-280878-1kt51viz	172	8	McCourt	McCourt	NNP
cord-280878-1kt51viz	172	9	,	,	,
cord-280878-1kt51viz	172	10	&	&	CC
cord-280878-1kt51viz	172	11	Rice	Rice	NNP
cord-280878-1kt51viz	172	12	,	,	,
cord-280878-1kt51viz	172	13	1994	1994	CD
cord-280878-1kt51viz	172	14	;	;	.
cord-280878-1kt51viz	173	1	Mizushima	Mizushima	NNP
cord-280878-1kt51viz	173	2	et	et	FW
cord-280878-1kt51viz	173	3	al	al	NNP
cord-280878-1kt51viz	173	4	.	.	NNP
cord-280878-1kt51viz	173	5	,	,	,
cord-280878-1kt51viz	173	6	1994	1994	CD
cord-280878-1kt51viz	173	7	)	)	-RRB-
cord-280878-1kt51viz	173	8	.	.	.
cord-280878-1kt51viz	174	1	The	the	DT
cord-280878-1kt51viz	174	2	p7	p7	NN
cord-280878-1kt51viz	174	3	protein	protein	NN
cord-280878-1kt51viz	174	4	is	be	VBZ
cord-280878-1kt51viz	174	5	63	63	CD
cord-280878-1kt51viz	174	6	residues	residue	NNS
cord-280878-1kt51viz	174	7	long	long	RB
cord-280878-1kt51viz	174	8	with	with	IN
cord-280878-1kt51viz	174	9	two	two	CD
cord-280878-1kt51viz	174	10	TM	TM	NNP
cord-280878-1kt51viz	174	11	domains	domain	NNS
cord-280878-1kt51viz	174	12	,	,	,
cord-280878-1kt51viz	174	13	found	find	VBN
cord-280878-1kt51viz	174	14	mainly	mainly	RB
cord-280878-1kt51viz	174	15	at	at	IN
cord-280878-1kt51viz	174	16	the	the	DT
cord-280878-1kt51viz	174	17	ER	ER	NNP
cord-280878-1kt51viz	174	18	membrane	membrane	NN
cord-280878-1kt51viz	174	19	.	.	.
cord-280878-1kt51viz	175	1	Although	although	IN
cord-280878-1kt51viz	175	2	p7	p7	NN
cord-280878-1kt51viz	175	3	is	be	VBZ
cord-280878-1kt51viz	175	4	not	not	RB
cord-280878-1kt51viz	175	5	necessary	necessary	JJ
cord-280878-1kt51viz	175	6	for	for	IN
cord-280878-1kt51viz	175	7	RNA	RNA	NNP
cord-280878-1kt51viz	175	8	replication	replication	NN
cord-280878-1kt51viz	175	9	(	(	-LRB-
cord-280878-1kt51viz	175	10	Lohmann	Lohmann	NNP
cord-280878-1kt51viz	175	11	et	et	NNP
cord-280878-1kt51viz	175	12	al	al	NNP
cord-280878-1kt51viz	175	13	.	.	NNP
cord-280878-1kt51viz	175	14	,	,	,
cord-280878-1kt51viz	175	15	1999	1999	CD
cord-280878-1kt51viz	175	16	)	)	-RRB-
cord-280878-1kt51viz	175	17	,	,	,
cord-280878-1kt51viz	175	18	it	-PRON-	PRP
cord-280878-1kt51viz	175	19	is	be	VBZ
cord-280878-1kt51viz	175	20	essential	essential	JJ
cord-280878-1kt51viz	175	21	for	for	IN
cord-280878-1kt51viz	175	22	productive	productive	JJ
cord-280878-1kt51viz	175	23	HCV	HCV	NNP
cord-280878-1kt51viz	175	24	propagation	propagation	NN
cord-280878-1kt51viz	175	25	in	in	IN
cord-280878-1kt51viz	175	26	vivo	vivo	NN
cord-280878-1kt51viz	175	27	.	.	.
cord-280878-1kt51viz	176	1	However	however	RB
cord-280878-1kt51viz	176	2	,	,	,
cord-280878-1kt51viz	176	3	the	the	DT
cord-280878-1kt51viz	176	4	precise	precise	JJ
cord-280878-1kt51viz	176	5	role	role	NN
cord-280878-1kt51viz	176	6	of	of	IN
cord-280878-1kt51viz	176	7	the	the	DT
cord-280878-1kt51viz	176	8	p7	p7	NN
cord-280878-1kt51viz	176	9	in	in	IN
cord-280878-1kt51viz	176	10	virus	virus	NN
cord-280878-1kt51viz	176	11	production	production	NN
cord-280878-1kt51viz	176	12	was	be	VBD
cord-280878-1kt51viz	176	13	only	only	RB
cord-280878-1kt51viz	176	14	determined	determine	VBN
cord-280878-1kt51viz	176	15	when	when	WRB
cord-280878-1kt51viz	176	16	it	-PRON-	PRP
cord-280878-1kt51viz	176	17	was	be	VBD
cord-280878-1kt51viz	176	18	possible	possible	JJ
cord-280878-1kt51viz	176	19	to	to	TO
cord-280878-1kt51viz	176	20	replicate	replicate	VB
cord-280878-1kt51viz	176	21	a	a	DT
cord-280878-1kt51viz	176	22	genotype	genotype	NN
cord-280878-1kt51viz	176	23	2a	2a	CD
cord-280878-1kt51viz	176	24	isolate	isolate	VBP
cord-280878-1kt51viz	176	25	from	from	IN
cord-280878-1kt51viz	176	26	a	a	DT
cord-280878-1kt51viz	176	27	Japanese	japanese	JJ
cord-280878-1kt51viz	176	28	patient	patient	NN
cord-280878-1kt51viz	176	29	suffering	suffer	VBG
cord-280878-1kt51viz	176	30	from	from	IN
cord-280878-1kt51viz	176	31	fulminant	fulminant	JJ
cord-280878-1kt51viz	176	32	hepatitis	hepatitis	NN
cord-280878-1kt51viz	176	33	(	(	-LRB-
cord-280878-1kt51viz	176	34	designated	designate	VBN
cord-280878-1kt51viz	176	35	JFH-1	JFH-1	NNPS
cord-280878-1kt51viz	176	36	)	)	-RRB-
cord-280878-1kt51viz	177	1	(	(	-LRB-
cord-280878-1kt51viz	177	2	Kato	Kato	NNP
cord-280878-1kt51viz	177	3	et	et	NNP
cord-280878-1kt51viz	177	4	al	al	NNP
cord-280878-1kt51viz	177	5	.	.	NNP
cord-280878-1kt51viz	177	6	,	,	,
cord-280878-1kt51viz	177	7	2003	2003	CD
cord-280878-1kt51viz	178	1	;	;	:
cord-280878-1kt51viz	178	2	Wakita	Wakita	NNP
cord-280878-1kt51viz	178	3	et	et	NNP
cord-280878-1kt51viz	178	4	al	al	NNP
cord-280878-1kt51viz	178	5	.	.	NNP
cord-280878-1kt51viz	178	6	,	,	,
cord-280878-1kt51viz	178	7	2005	2005	CD
cord-280878-1kt51viz	178	8	)	)	-RRB-
cord-280878-1kt51viz	178	9	.	.	.
cord-280878-1kt51viz	179	1	This	this	DT
cord-280878-1kt51viz	179	2	isolate	isolate	VBP
cord-280878-1kt51viz	179	3	efficiently	efficiently	RB
cord-280878-1kt51viz	179	4	replicated	replicate	VBN
cord-280878-1kt51viz	179	5	in	in	IN
cord-280878-1kt51viz	179	6	human	human	JJ
cord-280878-1kt51viz	179	7	hepatoma	hepatoma	NNP
cord-280878-1kt51viz	179	8	cell	cell	NN
cord-280878-1kt51viz	179	9	lines	line	NNS
cord-280878-1kt51viz	179	10	and	and	CC
cord-280878-1kt51viz	179	11	produced	produce	VBD
cord-280878-1kt51viz	179	12	infectious	infectious	JJ
cord-280878-1kt51viz	179	13	virus	virus	NN
cord-280878-1kt51viz	179	14	particles	particle	NNS
cord-280878-1kt51viz	179	15	.	.	.
cord-280878-1kt51viz	180	1	This	this	DT
cord-280878-1kt51viz	180	2	was	be	VBD
cord-280878-1kt51viz	180	3	used	use	VBN
cord-280878-1kt51viz	180	4	to	to	TO
cord-280878-1kt51viz	180	5	demonstrate	demonstrate	VB
cord-280878-1kt51viz	180	6	that	that	IN
cord-280878-1kt51viz	180	7	p7	p7	NN
cord-280878-1kt51viz	180	8	is	be	VBZ
cord-280878-1kt51viz	180	9	essential	essential	JJ
cord-280878-1kt51viz	180	10	for	for	IN
cord-280878-1kt51viz	180	11	virus	virus	NN
cord-280878-1kt51viz	180	12	particle	particle	NN
cord-280878-1kt51viz	180	13	assembly	assembly	NN
cord-280878-1kt51viz	180	14	and	and	CC
cord-280878-1kt51viz	180	15	release	release	NN
cord-280878-1kt51viz	180	16	(	(	-LRB-
cord-280878-1kt51viz	180	17	Jones	Jones	NNP
cord-280878-1kt51viz	180	18	,	,	,
cord-280878-1kt51viz	180	19	Murray	Murray	NNP
cord-280878-1kt51viz	180	20	,	,	,
cord-280878-1kt51viz	180	21	Eastman	Eastman	NNP
cord-280878-1kt51viz	180	22	,	,	,
cord-280878-1kt51viz	180	23	Tassello	Tassello	NNP
cord-280878-1kt51viz	180	24	,	,	,
cord-280878-1kt51viz	180	25	&	&	CC
cord-280878-1kt51viz	180	26	Rice	Rice	NNP
cord-280878-1kt51viz	180	27	,	,	,
cord-280878-1kt51viz	180	28	2007	2007	CD
cord-280878-1kt51viz	180	29	;	;	:
cord-280878-1kt51viz	180	30	Steinmann	Steinmann	NNP
cord-280878-1kt51viz	180	31	et	et	NNP
cord-280878-1kt51viz	180	32	al	al	NNP
cord-280878-1kt51viz	180	33	.	.	NNP
cord-280878-1kt51viz	180	34	,	,	,
cord-280878-1kt51viz	180	35	2007	2007	CD
cord-280878-1kt51viz	180	36	)	)	-RRB-
cord-280878-1kt51viz	180	37	.	.	.
cord-280878-1kt51viz	181	1	The	the	DT
cord-280878-1kt51viz	181	2	bovine	bovine	JJ
cord-280878-1kt51viz	181	3	viral	viral	JJ
cord-280878-1kt51viz	181	4	diarrhea	diarrhea	NN
cord-280878-1kt51viz	181	5	virus	virus	NN
cord-280878-1kt51viz	181	6	(	(	-LRB-
cord-280878-1kt51viz	181	7	BVDV	BVDV	NNP
cord-280878-1kt51viz	181	8	)	)	-RRB-
cord-280878-1kt51viz	182	1	(	(	-LRB-
cord-280878-1kt51viz	182	2	Harada	Harada	NNP
cord-280878-1kt51viz	182	3	,	,	,
cord-280878-1kt51viz	182	4	Tautz	Tautz	NNP
cord-280878-1kt51viz	182	5	,	,	,
cord-280878-1kt51viz	182	6	&	&	CC
cord-280878-1kt51viz	182	7	Thiel	Thiel	NNP
cord-280878-1kt51viz	182	8	,	,	,
cord-280878-1kt51viz	182	9	2000	2000	CD
cord-280878-1kt51viz	182	10	)	)	-RRB-
cord-280878-1kt51viz	182	11	and	and	CC
cord-280878-1kt51viz	182	12	the	the	DT
cord-280878-1kt51viz	182	13	hepacivirus	hepacivirus	JJ
cord-280878-1kt51viz	182	14	GB	GB	NNP
cord-280878-1kt51viz	182	15	virus	virus	NN
cord-280878-1kt51viz	182	16	B	b	NN
cord-280878-1kt51viz	182	17	(	(	-LRB-
cord-280878-1kt51viz	182	18	GBV	GBV	NNP
cord-280878-1kt51viz	182	19	-	-	HYPH
cord-280878-1kt51viz	182	20	B	B	NNP
cord-280878-1kt51viz	182	21	)	)	-RRB-
cord-280878-1kt51viz	183	1	(	(	-LRB-
cord-280878-1kt51viz	183	2	Takikawa	Takikawa	NNP
cord-280878-1kt51viz	183	3	et	et	NNP
cord-280878-1kt51viz	183	4	al	al	NNP
cord-280878-1kt51viz	183	5	.	.	NNP
cord-280878-1kt51viz	183	6	,	,	,
cord-280878-1kt51viz	183	7	2006	2006	CD
cord-280878-1kt51viz	183	8	)	)	-RRB-
cord-280878-1kt51viz	183	9	,	,	,
cord-280878-1kt51viz	183	10	HCV	HCV	NNP
cord-280878-1kt51viz	183	11	's	's	POS
cord-280878-1kt51viz	183	12	closest	close	JJS
cord-280878-1kt51viz	183	13	relatives	relative	NNS
cord-280878-1kt51viz	183	14	,	,	,
cord-280878-1kt51viz	183	15	also	also	RB
cord-280878-1kt51viz	183	16	have	have	VBP
cord-280878-1kt51viz	183	17	a	a	DT
cord-280878-1kt51viz	183	18	p7	p7	NN
cord-280878-1kt51viz	183	19	protein	protein	NN
cord-280878-1kt51viz	183	20	crucial	crucial	JJ
cord-280878-1kt51viz	183	21	for	for	IN
cord-280878-1kt51viz	183	22	virus	virus	NN
cord-280878-1kt51viz	183	23	replication	replication	NN
cord-280878-1kt51viz	183	24	.	.	.
cord-280878-1kt51viz	184	1	The	the	DT
cord-280878-1kt51viz	184	2	channel	channel	NN
cord-280878-1kt51viz	184	3	activity	activity	NN
cord-280878-1kt51viz	184	4	of	of	IN
cord-280878-1kt51viz	184	5	p7	p7	NN
cord-280878-1kt51viz	184	6	was	be	VBD
cord-280878-1kt51viz	184	7	examined	examine	VBN
cord-280878-1kt51viz	184	8	more	more	JJR
cord-280878-1kt51viz	184	9	than	than	IN
cord-280878-1kt51viz	184	10	10	10	CD
cord-280878-1kt51viz	184	11	years	year	NNS
cord-280878-1kt51viz	184	12	ago	ago	RB
cord-280878-1kt51viz	184	13	in	in	IN
cord-280878-1kt51viz	184	14	experiments	experiment	NNS
cord-280878-1kt51viz	184	15	involving	involve	VBG
cord-280878-1kt51viz	184	16	artificial	artificial	JJ
cord-280878-1kt51viz	184	17	lipid	lipid	NN
cord-280878-1kt51viz	184	18	bilayers	bilayer	NNS
cord-280878-1kt51viz	184	19	.	.	.
cord-280878-1kt51viz	185	1	It	-PRON-	PRP
cord-280878-1kt51viz	185	2	was	be	VBD
cord-280878-1kt51viz	185	3	suggested	suggest	VBN
cord-280878-1kt51viz	185	4	that	that	IN
cord-280878-1kt51viz	185	5	p7	p7	NN
cord-280878-1kt51viz	185	6	has	have	VBZ
cord-280878-1kt51viz	185	7	preference	preference	NN
cord-280878-1kt51viz	185	8	for	for	IN
cord-280878-1kt51viz	185	9	cations	cation	NNS
cord-280878-1kt51viz	185	10	vs	vs	IN
cord-280878-1kt51viz	185	11	anions	anion	NNS
cord-280878-1kt51viz	185	12	,	,	,
cord-280878-1kt51viz	185	13	with	with	IN
cord-280878-1kt51viz	185	14	permeability	permeability	NN
cord-280878-1kt51viz	185	15	ratios	ratio	NNS
cord-280878-1kt51viz	185	16	in	in	IN
cord-280878-1kt51viz	185	17	the	the	DT
cord-280878-1kt51viz	185	18	range	range	NN
cord-280878-1kt51viz	185	19	7	7	CD
cord-280878-1kt51viz	185	20	-	-	SYM
cord-280878-1kt51viz	185	21	11	11	CD
cord-280878-1kt51viz	186	1	(	(	-LRB-
cord-280878-1kt51viz	186	2	Griffin	Griffin	NNP
cord-280878-1kt51viz	186	3	et	et	NNP
cord-280878-1kt51viz	186	4	al	al	NNP
cord-280878-1kt51viz	186	5	.	.	NNP
cord-280878-1kt51viz	186	6	,	,	,
cord-280878-1kt51viz	186	7	2003	2003	CD
cord-280878-1kt51viz	187	1	;	;	:
cord-280878-1kt51viz	187	2	Montserret	Montserret	NNP
cord-280878-1kt51viz	187	3	et	et	NNP
cord-280878-1kt51viz	187	4	al	al	NNP
cord-280878-1kt51viz	187	5	.	.	NNP
cord-280878-1kt51viz	187	6	,	,	,
cord-280878-1kt51viz	187	7	2010	2010	CD
cord-280878-1kt51viz	187	8	;	;	:
cord-280878-1kt51viz	187	9	Premkumar	Premkumar	NNP
cord-280878-1kt51viz	187	10	,	,	,
cord-280878-1kt51viz	187	11	Wilson	Wilson	NNP
cord-280878-1kt51viz	187	12	,	,	,
cord-280878-1kt51viz	187	13	Ewart	Ewart	NNP
cord-280878-1kt51viz	187	14	,	,	,
cord-280878-1kt51viz	187	15	&	&	CC
cord-280878-1kt51viz	187	16	Gage	Gage	NNP
cord-280878-1kt51viz	187	17	,	,	,
cord-280878-1kt51viz	187	18	2004	2004	CD
cord-280878-1kt51viz	187	19	;	;	:
cord-280878-1kt51viz	187	20	Pavlovic	Pavlovic	NNP
cord-280878-1kt51viz	187	21	et	et	NNP
cord-280878-1kt51viz	187	22	al	al	NNP
cord-280878-1kt51viz	187	23	.	.	NNP
cord-280878-1kt51viz	187	24	,	,	,
cord-280878-1kt51viz	187	25	2003	2003	CD
cord-280878-1kt51viz	187	26	)	)	-RRB-
cord-280878-1kt51viz	187	27	and	and	CC
cord-280878-1kt51viz	187	28	more	more	RBR
cord-280878-1kt51viz	187	29	recently	recently	RB
cord-280878-1kt51viz	187	30	in	in	IN
cord-280878-1kt51viz	187	31	Xenopus	Xenopus	NNP
cord-280878-1kt51viz	187	32	oocytes	oocyte	NNS
cord-280878-1kt51viz	187	33	(	(	-LRB-
cord-280878-1kt51viz	187	34	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	187	35	et	et	NNP
cord-280878-1kt51viz	187	36	al	al	NNP
cord-280878-1kt51viz	187	37	.	.	NNP
cord-280878-1kt51viz	187	38	,	,	,
cord-280878-1kt51viz	187	39	2013	2013	CD
cord-280878-1kt51viz	187	40	)	)	-RRB-
cord-280878-1kt51viz	187	41	.	.	.
cord-280878-1kt51viz	188	1	This	this	DT
cord-280878-1kt51viz	188	2	selectivity	selectivity	NN
cord-280878-1kt51viz	188	3	is	be	VBZ
cord-280878-1kt51viz	188	4	rather	rather	RB
cord-280878-1kt51viz	188	5	low	low	JJ
cord-280878-1kt51viz	188	6	compared	compare	VBN
cord-280878-1kt51viz	188	7	to	to	IN
cord-280878-1kt51viz	188	8	other	other	JJ
cord-280878-1kt51viz	188	9	channels	channel	NNS
cord-280878-1kt51viz	188	10	,	,	,
cord-280878-1kt51viz	188	11	eg	eg	XX
cord-280878-1kt51viz	188	12	,	,	,
cord-280878-1kt51viz	188	13	for	for	IN
cord-280878-1kt51viz	188	14	cystic	cystic	JJ
cord-280878-1kt51viz	188	15	fibrosis	fibrosis	NN
cord-280878-1kt51viz	188	16	transmembrane	transmembrane	NNP
cord-280878-1kt51viz	188	17	conductance	conductance	NN
cord-280878-1kt51viz	188	18	regulator	regulator	NN
cord-280878-1kt51viz	188	19	(	(	-LRB-
cord-280878-1kt51viz	188	20	CFTR	CFTR	NNP
cord-280878-1kt51viz	188	21	)	)	-RRB-
cord-280878-1kt51viz	189	1	Cl	Cl	NNP
cord-280878-1kt51viz	189	2	À	à	NN
cord-280878-1kt51viz	189	3	channels	channel	NNS
cord-280878-1kt51viz	189	4	,	,	,
cord-280878-1kt51viz	189	5	selectivity	selectivity	NN
cord-280878-1kt51viz	189	6	for	for	IN
cord-280878-1kt51viz	189	7	anions	anion	NNS
cord-280878-1kt51viz	189	8	over	over	IN
cord-280878-1kt51viz	189	9	cations	cation	NNS
cord-280878-1kt51viz	189	10	is	be	VBZ
cord-280878-1kt51viz	189	11	10	10	CD
cord-280878-1kt51viz	189	12	-	-	SYM
cord-280878-1kt51viz	189	13	30	30	CD
cord-280878-1kt51viz	190	1	(	(	-LRB-
cord-280878-1kt51viz	190	2	Anderson	Anderson	NNP
cord-280878-1kt51viz	190	3	et	et	NNP
cord-280878-1kt51viz	190	4	al	al	NNP
cord-280878-1kt51viz	190	5	.	.	NNP
cord-280878-1kt51viz	190	6	,	,	,
cord-280878-1kt51viz	190	7	1991	1991	CD
cord-280878-1kt51viz	190	8	;	;	:
cord-280878-1kt51viz	191	1	Bear	Bear	NNP
cord-280878-1kt51viz	191	2	et	et	NNP
cord-280878-1kt51viz	191	3	al	al	NNP
cord-280878-1kt51viz	191	4	.	.	NNP
cord-280878-1kt51viz	191	5	,	,	,
cord-280878-1kt51viz	191	6	1992	1992	CD
cord-280878-1kt51viz	191	7	)	)	-RRB-
cord-280878-1kt51viz	191	8	.	.	.
cord-280878-1kt51viz	192	1	For	for	IN
cord-280878-1kt51viz	192	2	potassium	potassium	NN
cord-280878-1kt51viz	192	3	channels	channel	NNS
cord-280878-1kt51viz	192	4	,	,	,
cord-280878-1kt51viz	192	5	which	which	WDT
cord-280878-1kt51viz	192	6	conduct	conduct	VBP
cord-280878-1kt51viz	192	7	K	k	NN
cord-280878-1kt51viz	192	8	+	+	CC
cord-280878-1kt51viz	192	9	ions	ion	NNS
cord-280878-1kt51viz	192	10	near	near	IN
cord-280878-1kt51viz	192	11	the	the	DT
cord-280878-1kt51viz	192	12	diffusion	diffusion	NN
cord-280878-1kt51viz	192	13	limit	limit	NN
cord-280878-1kt51viz	192	14	,	,	,
cord-280878-1kt51viz	192	15	the	the	DT
cord-280878-1kt51viz	192	16	selectivity	selectivity	NN
cord-280878-1kt51viz	192	17	for	for	IN
cord-280878-1kt51viz	192	18	K	k	NN
cord-280878-1kt51viz	192	19	+	+	CC
cord-280878-1kt51viz	192	20	over	over	IN
cord-280878-1kt51viz	192	21	Na	Na	NNP
cord-280878-1kt51viz	192	22	+	+	CC
cord-280878-1kt51viz	192	23	is	be	VBZ
cord-280878-1kt51viz	192	24	about	about	RB
cord-280878-1kt51viz	192	25	10,000	10,000	CD
cord-280878-1kt51viz	192	26	-	-	SYM
cord-280878-1kt51viz	192	27	1	1	CD
cord-280878-1kt51viz	193	1	(	(	-LRB-
cord-280878-1kt51viz	193	2	Doyle	Doyle	NNP
cord-280878-1kt51viz	193	3	et	et	NNP
cord-280878-1kt51viz	193	4	al	al	NNP
cord-280878-1kt51viz	193	5	.	.	NNP
cord-280878-1kt51viz	193	6	,	,	,
cord-280878-1kt51viz	193	7	1998	1998	CD
cord-280878-1kt51viz	193	8	)	)	-RRB-
cord-280878-1kt51viz	193	9	,	,	,
cord-280878-1kt51viz	193	10	and	and	CC
cord-280878-1kt51viz	194	1	in	in	IN
cord-280878-1kt51viz	194	2	aquaporins	aquaporins	NNP
cord-280878-1kt51viz	194	3	water	water	NN
cord-280878-1kt51viz	194	4	to	to	TO
cord-280878-1kt51viz	194	5	ion	ion	NN
cord-280878-1kt51viz	194	6	flux	flux	NN
cord-280878-1kt51viz	194	7	ratio	ratio	NN
cord-280878-1kt51viz	194	8	is	be	VBZ
cord-280878-1kt51viz	194	9	about	about	RB
cord-280878-1kt51viz	194	10	10	10	CD
cord-280878-1kt51viz	194	11	9	9	CD
cord-280878-1kt51viz	194	12	(	(	-LRB-
cord-280878-1kt51viz	194	13	Pohl	Pohl	NNP
cord-280878-1kt51viz	194	14	,	,	,
cord-280878-1kt51viz	194	15	2004	2004	CD
cord-280878-1kt51viz	194	16	)	)	-RRB-
cord-280878-1kt51viz	194	17	.	.	.
cord-280878-1kt51viz	195	1	However	however	RB
cord-280878-1kt51viz	195	2	,	,	,
cord-280878-1kt51viz	195	3	the	the	DT
cord-280878-1kt51viz	195	4	biological	biological	JJ
cord-280878-1kt51viz	195	5	importance	importance	NN
cord-280878-1kt51viz	195	6	of	of	IN
cord-280878-1kt51viz	195	7	p7	p7	NNP
cord-280878-1kt51viz	195	8	cation	cation	NN
cord-280878-1kt51viz	195	9	channel	channel	NN
cord-280878-1kt51viz	195	10	activity	activity	NN
cord-280878-1kt51viz	195	11	may	may	MD
cord-280878-1kt51viz	195	12	be	be	VB
cord-280878-1kt51viz	195	13	relative	relative	JJ
cord-280878-1kt51viz	195	14	,	,	,
cord-280878-1kt51viz	195	15	in	in	IN
cord-280878-1kt51viz	195	16	the	the	DT
cord-280878-1kt51viz	195	17	light	light	NN
cord-280878-1kt51viz	195	18	of	of	IN
cord-280878-1kt51viz	195	19	its	-PRON-	PRP$
cord-280878-1kt51viz	195	20	recently	recently	RB
cord-280878-1kt51viz	195	21	found	find	VBN
cord-280878-1kt51viz	195	22	role	role	NN
cord-280878-1kt51viz	195	23	to	to	IN
cord-280878-1kt51viz	195	24	permeabilize	permeabilize	NNP
cord-280878-1kt51viz	195	25	membranes	membrane	NNS
cord-280878-1kt51viz	195	26	to	to	IN
cord-280878-1kt51viz	195	27	protons	proton	NNS
cord-280878-1kt51viz	195	28	,	,	,
cord-280878-1kt51viz	195	29	and	and	CC
cord-280878-1kt51viz	195	30	acting	act	VBG
cord-280878-1kt51viz	195	31	to	to	TO
cord-280878-1kt51viz	195	32	prevent	prevent	VB
cord-280878-1kt51viz	195	33	acidification	acidification	NN
cord-280878-1kt51viz	195	34	of	of	IN
cord-280878-1kt51viz	195	35	intracellular	intracellular	JJ
cord-280878-1kt51viz	195	36	vesicles	vesicle	NNS
cord-280878-1kt51viz	195	37	(	(	-LRB-
cord-280878-1kt51viz	195	38	Wozniak	Wozniak	NNP
cord-280878-1kt51viz	195	39	et	et	NNP
cord-280878-1kt51viz	195	40	al	al	NNP
cord-280878-1kt51viz	195	41	.	.	NNP
cord-280878-1kt51viz	195	42	,	,	,
cord-280878-1kt51viz	195	43	2010	2010	CD
cord-280878-1kt51viz	195	44	)	)	-RRB-
cord-280878-1kt51viz	195	45	.	.	.
cord-280878-1kt51viz	196	1	This	this	DT
cord-280878-1kt51viz	196	2	proton	proton	NN
cord-280878-1kt51viz	196	3	channel	channel	NN
cord-280878-1kt51viz	196	4	activity	activity	NN
cord-280878-1kt51viz	196	5	was	be	VBD
cord-280878-1kt51viz	196	6	found	find	VBN
cord-280878-1kt51viz	196	7	to	to	TO
cord-280878-1kt51viz	196	8	be	be	VB
cord-280878-1kt51viz	196	9	crucial	crucial	JJ
cord-280878-1kt51viz	196	10	for	for	IN
cord-280878-1kt51viz	196	11	the	the	DT
cord-280878-1kt51viz	196	12	production	production	NN
cord-280878-1kt51viz	196	13	of	of	IN
cord-280878-1kt51viz	196	14	infectious	infectious	JJ
cord-280878-1kt51viz	196	15	viruses	virus	NNS
cord-280878-1kt51viz	196	16	,	,	,
cord-280878-1kt51viz	196	17	and	and	CC
cord-280878-1kt51viz	196	18	was	be	VBD
cord-280878-1kt51viz	196	19	observed	observe	VBN
cord-280878-1kt51viz	196	20	in	in	IN
cord-280878-1kt51viz	196	21	intracellular	intracellular	JJ
cord-280878-1kt51viz	196	22	vesicles	vesicle	NNS
cord-280878-1kt51viz	196	23	harboring	harbor	VBG
cord-280878-1kt51viz	196	24	p7	p7	RB
cord-280878-1kt51viz	196	25	.	.	.
cord-280878-1kt51viz	197	1	Recently	recently	RB
cord-280878-1kt51viz	197	2	,	,	,
cord-280878-1kt51viz	197	3	this	this	DT
cord-280878-1kt51viz	197	4	proton	proton	NN
cord-280878-1kt51viz	197	5	channel	channel	NN
cord-280878-1kt51viz	197	6	activity	activity	NN
cord-280878-1kt51viz	197	7	has	have	VBZ
cord-280878-1kt51viz	197	8	been	be	VBN
cord-280878-1kt51viz	197	9	directly	directly	RB
cord-280878-1kt51viz	197	10	confirmed	confirm	VBN
cord-280878-1kt51viz	197	11	in	in	IN
cord-280878-1kt51viz	197	12	vitro	vitro	FW
cord-280878-1kt51viz	197	13	using	use	VBG
cord-280878-1kt51viz	197	14	purified	purify	VBN
cord-280878-1kt51viz	197	15	nontagged	nontagged	JJ
cord-280878-1kt51viz	197	16	p7	p7	NN
cord-280878-1kt51viz	197	17	protein	protein	NN
cord-280878-1kt51viz	197	18	in	in	IN
cord-280878-1kt51viz	197	19	a	a	DT
cord-280878-1kt51viz	197	20	liposome	liposome	NN
cord-280878-1kt51viz	197	21	-	-	HYPH
cord-280878-1kt51viz	197	22	based	base	VBN
cord-280878-1kt51viz	197	23	assay	assay	NN
cord-280878-1kt51viz	197	24	(	(	-LRB-
cord-280878-1kt51viz	197	25	Gan	Gan	NNP
cord-280878-1kt51viz	197	26	,	,	,
cord-280878-1kt51viz	197	27	Surya	Surya	NNP
cord-280878-1kt51viz	197	28	,	,	,
cord-280878-1kt51viz	197	29	Vararattanavech	Vararattanavech	NNP
cord-280878-1kt51viz	197	30	,	,	,
cord-280878-1kt51viz	197	31	&	&	CC
cord-280878-1kt51viz	197	32	Torres	Torres	NNP
cord-280878-1kt51viz	197	33	,	,	,
cord-280878-1kt51viz	197	34	2014	2014	CD
cord-280878-1kt51viz	197	35	)	)	-RRB-
cord-280878-1kt51viz	197	36	,	,	,
cord-280878-1kt51viz	197	37	where	where	WRB
cord-280878-1kt51viz	197	38	the	the	DT
cord-280878-1kt51viz	197	39	lipid	lipid	NN
cord-280878-1kt51viz	197	40	composition	composition	NN
cord-280878-1kt51viz	197	41	used	use	VBN
cord-280878-1kt51viz	197	42	was	be	VBD
cord-280878-1kt51viz	197	43	the	the	DT
cord-280878-1kt51viz	197	44	mixture	mixture	NN
cord-280878-1kt51viz	197	45	PAESC	PAESC	NNP
cord-280878-1kt51viz	197	46	(	(	-LRB-
cord-280878-1kt51viz	197	47	PA	PA	NNP
cord-280878-1kt51viz	197	48	/	/	SYM
cord-280878-1kt51viz	197	49	PE/	pe/	JJ
cord-280878-1kt51viz	197	50	PS	PS	NNP
cord-280878-1kt51viz	197	51	/	/	SYM
cord-280878-1kt51viz	197	52	PC	pc	NN
cord-280878-1kt51viz	197	53	5:2:2:1	5:2:2:1	CD
cord-280878-1kt51viz	197	54	w	w	NNP
cord-280878-1kt51viz	197	55	/	/	SYM
cord-280878-1kt51viz	197	56	w	w	NN
cord-280878-1kt51viz	197	57	)	)	-RRB-
cord-280878-1kt51viz	198	1	(	(	-LRB-
cord-280878-1kt51viz	198	2	Gervais	Gervais	NNP
cord-280878-1kt51viz	198	3	et	et	NNP
cord-280878-1kt51viz	198	4	al	al	NNP
cord-280878-1kt51viz	198	5	.	.	NNP
cord-280878-1kt51viz	198	6	,	,	,
cord-280878-1kt51viz	198	7	2011	2011	CD
cord-280878-1kt51viz	198	8	)	)	-RRB-
cord-280878-1kt51viz	198	9	.	.	.
cord-280878-1kt51viz	199	1	Several	several	JJ
cord-280878-1kt51viz	199	2	initial	initial	JJ
cord-280878-1kt51viz	199	3	papers	paper	NNS
cord-280878-1kt51viz	199	4	also	also	RB
cord-280878-1kt51viz	199	5	reported	report	VBD
cord-280878-1kt51viz	199	6	the	the	DT
cord-280878-1kt51viz	199	7	inhibition	inhibition	NN
cord-280878-1kt51viz	199	8	of	of	IN
cord-280878-1kt51viz	199	9	channel	channel	NN
cord-280878-1kt51viz	199	10	activity	activity	NN
cord-280878-1kt51viz	199	11	by	by	IN
cord-280878-1kt51viz	199	12	some	some	DT
cord-280878-1kt51viz	199	13	compounds	compound	NNS
cord-280878-1kt51viz	199	14	.	.	.
cord-280878-1kt51viz	200	1	For	for	IN
cord-280878-1kt51viz	200	2	example	example	NN
cord-280878-1kt51viz	200	3	,	,	,
cord-280878-1kt51viz	200	4	His	-PRON-	PRP$
cord-280878-1kt51viz	200	5	-	-	HYPH
cord-280878-1kt51viz	200	6	tagged	tag	VBN
cord-280878-1kt51viz	200	7	p7	p7	RB
cord-280878-1kt51viz	200	8	from	from	IN
cord-280878-1kt51viz	200	9	genotype	genotype	NN
cord-280878-1kt51viz	200	10	1b	1b	CD
cord-280878-1kt51viz	200	11	was	be	VBD
cord-280878-1kt51viz	200	12	inhibited	inhibit	VBN
cord-280878-1kt51viz	200	13	by	by	IN
cord-280878-1kt51viz	200	14	1	1	CD
cord-280878-1kt51viz	200	15	μM	μm	CD
cord-280878-1kt51viz	200	16	amantadine	amantadine	NNP
cord-280878-1kt51viz	200	17	(	(	-LRB-
cord-280878-1kt51viz	200	18	Griffin	Griffin	NNP
cord-280878-1kt51viz	200	19	et	et	NNP
cord-280878-1kt51viz	200	20	al	al	NNP
cord-280878-1kt51viz	200	21	.	.	NNP
cord-280878-1kt51viz	200	22	,	,	,
cord-280878-1kt51viz	200	23	2003	2003	CD
cord-280878-1kt51viz	200	24	)	)	-RRB-
cord-280878-1kt51viz	200	25	,	,	,
cord-280878-1kt51viz	200	26	whereas	whereas	IN
cord-280878-1kt51viz	200	27	synthetic	synthetic	JJ
cord-280878-1kt51viz	200	28	p7	p7	NN
cord-280878-1kt51viz	200	29	from	from	IN
cord-280878-1kt51viz	200	30	genotype	genotype	NN
cord-280878-1kt51viz	200	31	1a	1a	CD
cord-280878-1kt51viz	200	32	(	(	-LRB-
cord-280878-1kt51viz	200	33	strain	strain	NN
cord-280878-1kt51viz	200	34	H77	H77	NNP
cord-280878-1kt51viz	200	35	)	)	-RRB-
cord-280878-1kt51viz	200	36	was	be	VBD
cord-280878-1kt51viz	200	37	inhibited	inhibit	VBN
cord-280878-1kt51viz	200	38	by	by	IN
cord-280878-1kt51viz	200	39	100	100	CD
cord-280878-1kt51viz	200	40	μM	μm	CD
cord-280878-1kt51viz	200	41	hexamethyleneamiloride	hexamethyleneamiloride	NN
cord-280878-1kt51viz	200	42	(	(	-LRB-
cord-280878-1kt51viz	200	43	HMA	HMA	NNP
cord-280878-1kt51viz	200	44	,	,	,
cord-280878-1kt51viz	200	45	Fig	Fig	NNP
cord-280878-1kt51viz	200	46	.	.	.
cord-280878-1kt51viz	200	47	4A	4a	CD
cord-280878-1kt51viz	200	48	)	)	-RRB-
cord-280878-1kt51viz	200	49	,	,	,
cord-280878-1kt51viz	200	50	although	although	IN
cord-280878-1kt51viz	200	51	this	this	DT
cord-280878-1kt51viz	200	52	peptide	peptide	NN
cord-280878-1kt51viz	200	53	was	be	VBD
cord-280878-1kt51viz	200	54	largely	largely	RB
cord-280878-1kt51viz	200	55	unpurified	unpurified	JJ
cord-280878-1kt51viz	200	56	(	(	-LRB-
cord-280878-1kt51viz	200	57	Premkumar	Premkumar	NNP
cord-280878-1kt51viz	200	58	et	et	NNP
cord-280878-1kt51viz	200	59	al	al	NNP
cord-280878-1kt51viz	200	60	.	.	NNP
cord-280878-1kt51viz	200	61	,	,	,
cord-280878-1kt51viz	200	62	2004	2004	CD
cord-280878-1kt51viz	200	63	)	)	-RRB-
cord-280878-1kt51viz	200	64	.	.	.
cord-280878-1kt51viz	201	1	Another	another	DT
cord-280878-1kt51viz	201	2	synthetic	synthetic	NN
cord-280878-1kt51viz	201	3	p7	p7	NN
cord-280878-1kt51viz	201	4	,	,	,
cord-280878-1kt51viz	201	5	also	also	RB
cord-280878-1kt51viz	201	6	unpurified	unpurified	JJ
cord-280878-1kt51viz	201	7	,	,	,
cord-280878-1kt51viz	201	8	was	be	VBD
cord-280878-1kt51viz	201	9	inhibited	inhibit	VBN
cord-280878-1kt51viz	201	10	by	by	IN
cord-280878-1kt51viz	201	11	50	50	CD
cord-280878-1kt51viz	201	12	-	-	SYM
cord-280878-1kt51viz	201	13	100	100	CD
cord-280878-1kt51viz	201	14	μM	μm	NN
cord-280878-1kt51viz	201	15	of	of	IN
cord-280878-1kt51viz	201	16	the	the	DT
cord-280878-1kt51viz	201	17	long	long	JJ
cord-280878-1kt51viz	201	18	-	-	HYPH
cord-280878-1kt51viz	201	19	alkyl	alkyl	JJ
cord-280878-1kt51viz	201	20	-	-	HYPH
cord-280878-1kt51viz	201	21	chain	chain	NN
cord-280878-1kt51viz	201	22	imino	imino	NN
cord-280878-1kt51viz	201	23	sugar	sugar	NN
cord-280878-1kt51viz	201	24	derivatives	derivative	NNS
cord-280878-1kt51viz	201	25	NN	NN	NNP
cord-280878-1kt51viz	201	26	-	-	HYPH
cord-280878-1kt51viz	201	27	DGJ	DGJ	NNP
cord-280878-1kt51viz	201	28	,	,	,
cord-280878-1kt51viz	201	29	NN	NN	NNP
cord-280878-1kt51viz	201	30	-	-	HYPH
cord-280878-1kt51viz	201	31	DNJ	DNJ	NNP
cord-280878-1kt51viz	201	32	(	(	-LRB-
cord-280878-1kt51viz	201	33	Fig	fig	NN
cord-280878-1kt51viz	201	34	.	.	.
cord-280878-1kt51viz	201	35	4B	4b	LS
cord-280878-1kt51viz	201	36	)	)	-RRB-
cord-280878-1kt51viz	201	37	and	and	CC
cord-280878-1kt51viz	201	38	N-7-oxanonyl-6-deoxy	N-7-oxanonyl-6-deoxy	NNP
cord-280878-1kt51viz	201	39	-	-	HYPH
cord-280878-1kt51viz	201	40	DGJ	DGJ	NNP
cord-280878-1kt51viz	201	41	(	(	-LRB-
cord-280878-1kt51viz	201	42	Pavlovic	Pavlovic	NNP
cord-280878-1kt51viz	201	43	et	et	FW
cord-280878-1kt51viz	201	44	al	al	NNP
cord-280878-1kt51viz	201	45	.	.	NNP
cord-280878-1kt51viz	201	46	,	,	,
cord-280878-1kt51viz	201	47	2003	2003	CD
cord-280878-1kt51viz	201	48	)	)	-RRB-
cord-280878-1kt51viz	201	49	.	.	.
cord-280878-1kt51viz	202	1	However	however	RB
cord-280878-1kt51viz	202	2	,	,	,
cord-280878-1kt51viz	202	3	the	the	DT
cord-280878-1kt51viz	202	4	channel	channel	NN
cord-280878-1kt51viz	202	5	activity	activity	NN
cord-280878-1kt51viz	202	6	of	of	IN
cord-280878-1kt51viz	202	7	purified	purify	VBN
cord-280878-1kt51viz	202	8	synthetic	synthetic	JJ
cord-280878-1kt51viz	202	9	p7	p7	NN
cord-280878-1kt51viz	202	10	HCV	HCV	NNP
cord-280878-1kt51viz	202	11	-	-	HYPH
cord-280878-1kt51viz	202	12	J	J	NNP
cord-280878-1kt51viz	202	13	genotype	genotype	NN
cord-280878-1kt51viz	202	14	1b	1b	CD
cord-280878-1kt51viz	202	15	in	in	IN
cord-280878-1kt51viz	202	16	artificial	artificial	JJ
cord-280878-1kt51viz	202	17	lipid	lipid	NN
cord-280878-1kt51viz	202	18	bilayers	bilayer	NNS
cord-280878-1kt51viz	202	19	was	be	VBD
cord-280878-1kt51viz	202	20	inhibited	inhibit	VBN
cord-280878-1kt51viz	202	21	by	by	IN
cord-280878-1kt51viz	202	22	just	just	RB
cord-280878-1kt51viz	202	23	50	50	CD
cord-280878-1kt51viz	202	24	%	%	NN
cord-280878-1kt51viz	202	25	in	in	IN
cord-280878-1kt51viz	202	26	the	the	DT
cord-280878-1kt51viz	202	27	presence	presence	NN
cord-280878-1kt51viz	202	28	of	of	IN
cord-280878-1kt51viz	202	29	200	200	CD
cord-280878-1kt51viz	202	30	μM	μm	CD
cord-280878-1kt51viz	202	31	HMA	HMA	NNP
cord-280878-1kt51viz	202	32	,	,	,
cord-280878-1kt51viz	202	33	whereas	whereas	IN
cord-280878-1kt51viz	202	34	Amt	Amt	NNP
cord-280878-1kt51viz	202	35	did	do	VBD
cord-280878-1kt51viz	202	36	not	not	RB
cord-280878-1kt51viz	202	37	show	show	VB
cord-280878-1kt51viz	202	38	any	any	DT
cord-280878-1kt51viz	202	39	effect	effect	NN
cord-280878-1kt51viz	202	40	even	even	RB
cord-280878-1kt51viz	202	41	at	at	IN
cord-280878-1kt51viz	202	42	1	1	CD
cord-280878-1kt51viz	202	43	mM	mm	CD
cord-280878-1kt51viz	202	44	concentration	concentration	NN
cord-280878-1kt51viz	202	45	(	(	-LRB-
cord-280878-1kt51viz	202	46	Montserret	Montserret	NNP
cord-280878-1kt51viz	202	47	et	et	NNP
cord-280878-1kt51viz	202	48	al	al	NNP
cord-280878-1kt51viz	202	49	.	.	NNP
cord-280878-1kt51viz	202	50	,	,	,
cord-280878-1kt51viz	202	51	2010	2010	CD
cord-280878-1kt51viz	202	52	)	)	-RRB-
cord-280878-1kt51viz	202	53	.	.	.
cord-280878-1kt51viz	203	1	In	in	IN
cord-280878-1kt51viz	203	2	fact	fact	NN
cord-280878-1kt51viz	203	3	,	,	,
cord-280878-1kt51viz	203	4	the	the	DT
cord-280878-1kt51viz	203	5	efficacy	efficacy	NN
cord-280878-1kt51viz	203	6	of	of	IN
cord-280878-1kt51viz	203	7	Amt	Amt	NNP
cord-280878-1kt51viz	203	8	in	in	IN
cord-280878-1kt51viz	203	9	HCV	HCV	NNP
cord-280878-1kt51viz	203	10	culture	culture	NN
cord-280878-1kt51viz	203	11	systems	system	NNS
cord-280878-1kt51viz	203	12	is	be	VBZ
cord-280878-1kt51viz	203	13	low	low	JJ
cord-280878-1kt51viz	204	1	(	(	-LRB-
cord-280878-1kt51viz	204	2	Steinmann	Steinmann	NNP
cord-280878-1kt51viz	204	3	et	et	NNP
cord-280878-1kt51viz	204	4	al	al	NNP
cord-280878-1kt51viz	204	5	.	.	NNP
cord-280878-1kt51viz	204	6	,	,	,
cord-280878-1kt51viz	204	7	2007	2007	CD
cord-280878-1kt51viz	204	8	)	)	-RRB-
cord-280878-1kt51viz	204	9	,	,	,
cord-280878-1kt51viz	204	10	and	and	CC
cord-280878-1kt51viz	204	11	no	no	DT
cord-280878-1kt51viz	204	12	clinical	clinical	JJ
cord-280878-1kt51viz	204	13	benefit	benefit	NN
cord-280878-1kt51viz	204	14	of	of	IN
cord-280878-1kt51viz	204	15	Amt	Amt	NNP
cord-280878-1kt51viz	204	16	-	-	HYPH
cord-280878-1kt51viz	204	17	based	base	VBN
cord-280878-1kt51viz	204	18	combination	combination	NN
cord-280878-1kt51viz	204	19	therapy	therapy	NN
cord-280878-1kt51viz	204	20	was	be	VBD
cord-280878-1kt51viz	204	21	found	find	VBN
cord-280878-1kt51viz	204	22	in	in	IN
cord-280878-1kt51viz	204	23	comparison	comparison	NN
cord-280878-1kt51viz	204	24	to	to	IN
cord-280878-1kt51viz	204	25	standard	standard	NN
cord-280878-1kt51viz	204	26	of	of	IN
cord-280878-1kt51viz	204	27	care	care	NN
cord-280878-1kt51viz	204	28	(	(	-LRB-
cord-280878-1kt51viz	204	29	peg	peg	NNP
cord-280878-1kt51viz	204	30	-	-	HYPH
cord-280878-1kt51viz	204	31	IFNα	IFNα	NNP
cord-280878-1kt51viz	204	32	plus	plus	CC
cord-280878-1kt51viz	204	33	ribavirin	ribavirin	NN
cord-280878-1kt51viz	204	34	)	)	-RRB-
cord-280878-1kt51viz	205	1	(	(	-LRB-
cord-280878-1kt51viz	205	2	Castelain	Castelain	NNP
cord-280878-1kt51viz	205	3	et	et	NNP
cord-280878-1kt51viz	205	4	al	al	NNP
cord-280878-1kt51viz	205	5	.	.	NNP
cord-280878-1kt51viz	205	6	,	,	,
cord-280878-1kt51viz	205	7	2007	2007	CD
cord-280878-1kt51viz	206	1	;	;	:
cord-280878-1kt51viz	206	2	Mihm	Mihm	NNP
cord-280878-1kt51viz	206	3	et	et	NNP
cord-280878-1kt51viz	206	4	al	al	NNP
cord-280878-1kt51viz	206	5	.	.	NNP
cord-280878-1kt51viz	206	6	,	,	,
cord-280878-1kt51viz	206	7	2006	2006	CD
cord-280878-1kt51viz	206	8	)	)	-RRB-
cord-280878-1kt51viz	206	9	.	.	.
cord-280878-1kt51viz	207	1	Some	some	DT
cord-280878-1kt51viz	207	2	of	of	IN
cord-280878-1kt51viz	207	3	these	these	DT
cord-280878-1kt51viz	207	4	compounds	compound	NNS
cord-280878-1kt51viz	207	5	have	have	VBP
cord-280878-1kt51viz	207	6	been	be	VBN
cord-280878-1kt51viz	207	7	studied	study	VBN
cord-280878-1kt51viz	207	8	in	in	IN
cord-280878-1kt51viz	207	9	infected	infected	JJ
cord-280878-1kt51viz	207	10	cells	cell	NNS
cord-280878-1kt51viz	207	11	,	,	,
cord-280878-1kt51viz	207	12	where	where	WRB
cord-280878-1kt51viz	207	13	they	-PRON-	PRP
cord-280878-1kt51viz	207	14	reduced	reduce	VBD
cord-280878-1kt51viz	207	15	virus	virus	NN
cord-280878-1kt51viz	207	16	production	production	NN
cord-280878-1kt51viz	207	17	up	up	IN
cord-280878-1kt51viz	207	18	to	to	IN
cord-280878-1kt51viz	207	19	10-fold	10-fold	CD
cord-280878-1kt51viz	207	20	in	in	IN
cord-280878-1kt51viz	207	21	a	a	DT
cord-280878-1kt51viz	207	22	genotype	genotype	NN
cord-280878-1kt51viz	207	23	-	-	HYPH
cord-280878-1kt51viz	207	24	dependent	dependent	JJ
cord-280878-1kt51viz	207	25	manner	manner	NN
cord-280878-1kt51viz	207	26	(	(	-LRB-
cord-280878-1kt51viz	207	27	Foster	Foster	NNP
cord-280878-1kt51viz	207	28	et	et	NNP
cord-280878-1kt51viz	207	29	al	al	NNP
cord-280878-1kt51viz	207	30	.	.	NNP
cord-280878-1kt51viz	207	31	,	,	,
cord-280878-1kt51viz	207	32	2014	2014	CD
cord-280878-1kt51viz	207	33	;	;	:
cord-280878-1kt51viz	207	34	Gottwein	Gottwein	NNP
cord-280878-1kt51viz	207	35	et	et	NNP
cord-280878-1kt51viz	207	36	al	al	NNP
cord-280878-1kt51viz	207	37	.	.	NNP
cord-280878-1kt51viz	207	38	,	,	,
cord-280878-1kt51viz	207	39	2011	2011	CD
cord-280878-1kt51viz	207	40	;	;	:
cord-280878-1kt51viz	207	41	Steinmann	Steinmann	NNP
cord-280878-1kt51viz	207	42	et	et	NNP
cord-280878-1kt51viz	207	43	al	al	NNP
cord-280878-1kt51viz	207	44	.	.	NNP
cord-280878-1kt51viz	207	45	,	,	,
cord-280878-1kt51viz	207	46	2007	2007	CD
cord-280878-1kt51viz	207	47	)	)	-RRB-
cord-280878-1kt51viz	207	48	,	,	,
cord-280878-1kt51viz	207	49	reducing	reduce	VBG
cord-280878-1kt51viz	207	50	secretion	secretion	NN
cord-280878-1kt51viz	207	51	of	of	IN
cord-280878-1kt51viz	207	52	HCV	HCV	NNP
cord-280878-1kt51viz	207	53	particles	particle	NNS
cord-280878-1kt51viz	207	54	by	by	IN
cord-280878-1kt51viz	207	55	inhibition	inhibition	NN
cord-280878-1kt51viz	207	56	of	of	IN
cord-280878-1kt51viz	207	57	the	the	DT
cord-280878-1kt51viz	207	58	acidification	acidification	NN
cord-280878-1kt51viz	207	59	of	of	IN
cord-280878-1kt51viz	207	60	viruscontaining	viruscontaine	VBG
cord-280878-1kt51viz	207	61	compartments	compartment	NNS
cord-280878-1kt51viz	207	62	(	(	-LRB-
cord-280878-1kt51viz	207	63	Wozniak	Wozniak	NNP
cord-280878-1kt51viz	207	64	et	et	NNP
cord-280878-1kt51viz	207	65	al	al	NNP
cord-280878-1kt51viz	207	66	.	.	NNP
cord-280878-1kt51viz	207	67	,	,	,
cord-280878-1kt51viz	207	68	2010	2010	CD
cord-280878-1kt51viz	207	69	)	)	-RRB-
cord-280878-1kt51viz	207	70	,	,	,
cord-280878-1kt51viz	207	71	without	without	IN
cord-280878-1kt51viz	207	72	impairment	impairment	NN
cord-280878-1kt51viz	207	73	of	of	IN
cord-280878-1kt51viz	207	74	the	the	DT
cord-280878-1kt51viz	207	75	infectivity	infectivity	NN
cord-280878-1kt51viz	207	76	of	of	IN
cord-280878-1kt51viz	207	77	intracellular	intracellular	JJ
cord-280878-1kt51viz	207	78	virions	virion	NNS
cord-280878-1kt51viz	207	79	(	(	-LRB-
cord-280878-1kt51viz	207	80	Foster	Foster	NNP
cord-280878-1kt51viz	207	81	et	et	NNP
cord-280878-1kt51viz	207	82	al	al	NNP
cord-280878-1kt51viz	207	83	.	.	.
cord-280878-1kt51viz	208	1	,	,	,
cord-280878-1kt51viz	208	2	2011	2011	CD
cord-280878-1kt51viz	208	3	;	;	:
cord-280878-1kt51viz	208	4	Griffin	Griffin	NNP
cord-280878-1kt51viz	208	5	et	et	NNP
cord-280878-1kt51viz	208	6	al	al	NNP
cord-280878-1kt51viz	208	7	.	.	NNP
cord-280878-1kt51viz	208	8	,	,	,
cord-280878-1kt51viz	208	9	2008	2008	CD
cord-280878-1kt51viz	208	10	)	)	-RRB-
cord-280878-1kt51viz	208	11	.	.	.
cord-280878-1kt51viz	209	1	To	to	TO
cord-280878-1kt51viz	209	2	discover	discover	VB
cord-280878-1kt51viz	209	3	more	more	JJR
cord-280878-1kt51viz	209	4	p7	p7	IN
cord-280878-1kt51viz	209	5	channel	channel	NN
cord-280878-1kt51viz	209	6	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	209	7	,	,	,
cord-280878-1kt51viz	209	8	a	a	DT
cord-280878-1kt51viz	209	9	liposome	liposome	NN
cord-280878-1kt51viz	209	10	-	-	HYPH
cord-280878-1kt51viz	209	11	based	base	VBN
cord-280878-1kt51viz	209	12	dye	dye	NN
cord-280878-1kt51viz	209	13	(	(	-LRB-
cord-280878-1kt51viz	209	14	carboxyfluorescein	carboxyfluorescein	NNP
cord-280878-1kt51viz	209	15	,	,	,
cord-280878-1kt51viz	209	16	CF	CF	NNP
cord-280878-1kt51viz	209	17	)	)	-RRB-
cord-280878-1kt51viz	209	18	release	release	NN
cord-280878-1kt51viz	209	19	assay	assay	NN
cord-280878-1kt51viz	209	20	has	have	VBZ
cord-280878-1kt51viz	209	21	been	be	VBN
cord-280878-1kt51viz	209	22	proposed	propose	VBN
cord-280878-1kt51viz	209	23	that	that	WDT
cord-280878-1kt51viz	209	24	involves	involve	VBZ
cord-280878-1kt51viz	209	25	the	the	DT
cord-280878-1kt51viz	209	26	addition	addition	NN
cord-280878-1kt51viz	209	27	of	of	IN
cord-280878-1kt51viz	209	28	p7	p7	DT
cord-280878-1kt51viz	209	29	protein	protein	NN
cord-280878-1kt51viz	209	30	to	to	IN
cord-280878-1kt51viz	209	31	preloaded	preloaded	JJ
cord-280878-1kt51viz	209	32	liposomes	liposome	NNS
cord-280878-1kt51viz	209	33	(	(	-LRB-
cord-280878-1kt51viz	209	34	StGelais	StGelais	NNP
cord-280878-1kt51viz	209	35	et	et	NNP
cord-280878-1kt51viz	209	36	al	al	NNP
cord-280878-1kt51viz	209	37	.	.	NNP
cord-280878-1kt51viz	209	38	,	,	,
cord-280878-1kt51viz	209	39	2007	2007	CD
cord-280878-1kt51viz	209	40	)	)	-RRB-
cord-280878-1kt51viz	209	41	.	.	.
cord-280878-1kt51viz	210	1	The	the	DT
cord-280878-1kt51viz	210	2	method	method	NN
cord-280878-1kt51viz	210	3	has	have	VBZ
cord-280878-1kt51viz	210	4	been	be	VBN
cord-280878-1kt51viz	210	5	claimed	claim	VBN
cord-280878-1kt51viz	210	6	to	to	TO
cord-280878-1kt51viz	210	7	be	be	VB
cord-280878-1kt51viz	210	8	sensitive	sensitive	JJ
cord-280878-1kt51viz	210	9	to	to	IN
cord-280878-1kt51viz	210	10	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	210	11	such	such	JJ
cord-280878-1kt51viz	210	12	as	as	IN
cord-280878-1kt51viz	210	13	Amt	Amt	NNP
cord-280878-1kt51viz	210	14	and	and	CC
cord-280878-1kt51viz	210	15	Rim	Rim	NNP
cord-280878-1kt51viz	210	16	,	,	,
cord-280878-1kt51viz	210	17	and	and	CC
cord-280878-1kt51viz	210	18	proposed	propose	VBD
cord-280878-1kt51viz	210	19	as	as	IN
cord-280878-1kt51viz	210	20	a	a	DT
cord-280878-1kt51viz	210	21	high	high	JJ
cord-280878-1kt51viz	210	22	-	-	HYPH
cord-280878-1kt51viz	210	23	throughput	throughput	NN
cord-280878-1kt51viz	210	24	functional	functional	JJ
cord-280878-1kt51viz	210	25	assay	assay	NN
cord-280878-1kt51viz	210	26	to	to	TO
cord-280878-1kt51viz	210	27	test	test	VB
cord-280878-1kt51viz	210	28	drug	drug	NN
cord-280878-1kt51viz	210	29	sensitivity	sensitivity	NN
cord-280878-1kt51viz	210	30	of	of	IN
cord-280878-1kt51viz	210	31	p7	p7	NN
cord-280878-1kt51viz	210	32	mutants	mutant	NNS
cord-280878-1kt51viz	210	33	,	,	,
cord-280878-1kt51viz	210	34	or	or	CC
cord-280878-1kt51viz	210	35	to	to	TO
cord-280878-1kt51viz	210	36	discover	discover	VB
cord-280878-1kt51viz	210	37	new	new	JJ
cord-280878-1kt51viz	210	38	p7	p7	NN
cord-280878-1kt51viz	210	39	channel	channel	NN
cord-280878-1kt51viz	210	40	activity	activity	NN
cord-280878-1kt51viz	210	41	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	210	42	(	(	-LRB-
cord-280878-1kt51viz	210	43	Foster	Foster	NNP
cord-280878-1kt51viz	210	44	et	et	NNP
cord-280878-1kt51viz	210	45	al	al	NNP
cord-280878-1kt51viz	210	46	.	.	NNP
cord-280878-1kt51viz	210	47	,	,	,
cord-280878-1kt51viz	210	48	2011	2011	CD
cord-280878-1kt51viz	210	49	;	;	:
cord-280878-1kt51viz	211	1	Gervais	Gervais	NNP
cord-280878-1kt51viz	211	2	et	et	NNP
cord-280878-1kt51viz	211	3	al	al	NNP
cord-280878-1kt51viz	211	4	.	.	.
cord-280878-1kt51viz	212	1	,	,	,
cord-280878-1kt51viz	212	2	2011	2011	CD
cord-280878-1kt51viz	212	3	)	)	-RRB-
cord-280878-1kt51viz	212	4	.	.	.
cord-280878-1kt51viz	213	1	These	these	DT
cord-280878-1kt51viz	213	2	dye	dye	NN
cord-280878-1kt51viz	213	3	release	release	NN
cord-280878-1kt51viz	213	4	assays	assay	NNS
cord-280878-1kt51viz	213	5	have	have	VBP
cord-280878-1kt51viz	213	6	been	be	VBN
cord-280878-1kt51viz	213	7	previously	previously	RB
cord-280878-1kt51viz	213	8	performed	perform	VBN
cord-280878-1kt51viz	213	9	with	with	IN
cord-280878-1kt51viz	213	10	tagged	tagged	NNP
cord-280878-1kt51viz	213	11	p7	p7	NNP
cord-280878-1kt51viz	213	12	protein	protein	NN
cord-280878-1kt51viz	213	13	,	,	,
cord-280878-1kt51viz	213	14	either	either	CC
cord-280878-1kt51viz	213	15	with	with	IN
cord-280878-1kt51viz	213	16	FLAG	flag	NN
cord-280878-1kt51viz	214	1	(	(	-LRB-
cord-280878-1kt51viz	214	2	Li	Li	NNP
cord-280878-1kt51viz	214	3	et	et	NNP
cord-280878-1kt51viz	214	4	al	al	NNP
cord-280878-1kt51viz	214	5	.	.	NNP
cord-280878-1kt51viz	214	6	,	,	,
cord-280878-1kt51viz	214	7	2012	2012	CD
cord-280878-1kt51viz	214	8	;	;	.
cord-280878-1kt51viz	215	1	StGelais	StGelais	NNP
cord-280878-1kt51viz	215	2	et	et	NNP
cord-280878-1kt51viz	215	3	al	al	NNP
cord-280878-1kt51viz	215	4	.	.	NNP
cord-280878-1kt51viz	215	5	,	,	,
cord-280878-1kt51viz	215	6	2009	2009	CD
cord-280878-1kt51viz	215	7	)	)	-RRB-
cord-280878-1kt51viz	215	8	or	or	CC
cord-280878-1kt51viz	215	9	flu	flu	NN
cord-280878-1kt51viz	215	10	-	-	HYPH
cord-280878-1kt51viz	215	11	antigen	antigen	NN
cord-280878-1kt51viz	215	12	(	(	-LRB-
cord-280878-1kt51viz	215	13	Foster	Foster	NNP
cord-280878-1kt51viz	215	14	et	et	NNP
cord-280878-1kt51viz	215	15	al	al	NNP
cord-280878-1kt51viz	215	16	.	.	NNP
cord-280878-1kt51viz	215	17	,	,	,
cord-280878-1kt51viz	215	18	2011	2011	CD
cord-280878-1kt51viz	215	19	)	)	-RRB-
cord-280878-1kt51viz	215	20	.	.	.
cord-280878-1kt51viz	216	1	However	however	RB
cord-280878-1kt51viz	216	2	,	,	,
cord-280878-1kt51viz	216	3	this	this	DT
cord-280878-1kt51viz	216	4	method	method	NN
cord-280878-1kt51viz	216	5	has	have	VBZ
cord-280878-1kt51viz	216	6	been	be	VBN
cord-280878-1kt51viz	216	7	put	put	VBN
cord-280878-1kt51viz	216	8	into	into	IN
cord-280878-1kt51viz	216	9	question	question	NN
cord-280878-1kt51viz	216	10	since	since	IN
cord-280878-1kt51viz	216	11	just	just	RB
cord-280878-1kt51viz	216	12	the	the	DT
cord-280878-1kt51viz	216	13	C	C	NNP
cord-280878-1kt51viz	216	14	-	-	HYPH
cord-280878-1kt51viz	216	15	terminal	terminal	NN
cord-280878-1kt51viz	216	16	half	half	NN
cord-280878-1kt51viz	216	17	of	of	IN
cord-280878-1kt51viz	216	18	p7	p7	NN
cord-280878-1kt51viz	216	19	,	,	,
cord-280878-1kt51viz	216	20	p7(27	p7(27	NNP
cord-280878-1kt51viz	216	21	-	-	HYPH
cord-280878-1kt51viz	216	22	63	63	CD
cord-280878-1kt51viz	216	23	)	)	-RRB-
cord-280878-1kt51viz	216	24	was	be	VBD
cord-280878-1kt51viz	216	25	as	as	RB
cord-280878-1kt51viz	216	26	efficient	efficient	JJ
cord-280878-1kt51viz	216	27	as	as	IN
cord-280878-1kt51viz	216	28	full	full	JJ
cord-280878-1kt51viz	216	29	-	-	HYPH
cord-280878-1kt51viz	216	30	length	length	NN
cord-280878-1kt51viz	216	31	p7	p7	NN
cord-280878-1kt51viz	216	32	in	in	IN
cord-280878-1kt51viz	216	33	releasing	release	VBG
cord-280878-1kt51viz	216	34	CF	CF	NNP
cord-280878-1kt51viz	216	35	,	,	,
cord-280878-1kt51viz	216	36	while	while	IN
cord-280878-1kt51viz	216	37	a	a	DT
cord-280878-1kt51viz	216	38	properly	properly	RB
cord-280878-1kt51viz	216	39	reconstituted	reconstitute	VBN
cord-280878-1kt51viz	216	40	α	α	NN
cord-280878-1kt51viz	216	41	-	-	HYPH
cord-280878-1kt51viz	216	42	helical	helical	JJ
cord-280878-1kt51viz	216	43	sample	sample	NN
cord-280878-1kt51viz	216	44	of	of	IN
cord-280878-1kt51viz	216	45	p7	p7	NN
cord-280878-1kt51viz	216	46	was	be	VBD
cord-280878-1kt51viz	216	47	not	not	RB
cord-280878-1kt51viz	216	48	able	able	JJ
cord-280878-1kt51viz	216	49	to	to	TO
cord-280878-1kt51viz	216	50	elicit	elicit	VB
cord-280878-1kt51viz	216	51	CF	CF	NNP
cord-280878-1kt51viz	216	52	release	release	NN
cord-280878-1kt51viz	216	53	(	(	-LRB-
cord-280878-1kt51viz	216	54	Gan	Gan	NNP
cord-280878-1kt51viz	216	55	et	et	FW
cord-280878-1kt51viz	216	56	al	al	NNP
cord-280878-1kt51viz	216	57	.	.	NNP
cord-280878-1kt51viz	216	58	,	,	,
cord-280878-1kt51viz	216	59	2014	2014	CD
cord-280878-1kt51viz	216	60	)	)	-RRB-
cord-280878-1kt51viz	216	61	.	.	.
cord-280878-1kt51viz	217	1	Nevertheless	nevertheless	RB
cord-280878-1kt51viz	217	2	,	,	,
cord-280878-1kt51viz	217	3	p7	p7	NN
cord-280878-1kt51viz	217	4	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	217	5	may	may	MD
cord-280878-1kt51viz	217	6	be	be	VB
cord-280878-1kt51viz	217	7	able	able	JJ
cord-280878-1kt51viz	217	8	to	to	TO
cord-280878-1kt51viz	217	9	inhibit	inhibit	VB
cord-280878-1kt51viz	217	10	both	both	CC
cord-280878-1kt51viz	217	11	the	the	DT
cord-280878-1kt51viz	217	12	proton	proton	NN
cord-280878-1kt51viz	217	13	channel	channel	NN
cord-280878-1kt51viz	217	14	activity	activity	NN
cord-280878-1kt51viz	217	15	and	and	CC
cord-280878-1kt51viz	217	16	dye	dye	NN
cord-280878-1kt51viz	217	17	release	release	NN
cord-280878-1kt51viz	217	18	if	if	IN
cord-280878-1kt51viz	217	19	the	the	DT
cord-280878-1kt51viz	217	20	mechanisms	mechanism	NNS
cord-280878-1kt51viz	217	21	are	be	VBP
cord-280878-1kt51viz	217	22	similar	similar	JJ
cord-280878-1kt51viz	217	23	,	,	,
cord-280878-1kt51viz	217	24	eg	eg	JJ
cord-280878-1kt51viz	217	25	,	,	,
cord-280878-1kt51viz	217	26	via	via	IN
cord-280878-1kt51viz	217	27	an	an	DT
cord-280878-1kt51viz	217	28	allosteric	allosteric	JJ
cord-280878-1kt51viz	217	29	effect	effect	NN
cord-280878-1kt51viz	217	30	that	that	WDT
cord-280878-1kt51viz	217	31	increases	increase	VBZ
cord-280878-1kt51viz	217	32	the	the	DT
cord-280878-1kt51viz	217	33	rigidity	rigidity	NN
cord-280878-1kt51viz	217	34	of	of	IN
cord-280878-1kt51viz	217	35	the	the	DT
cord-280878-1kt51viz	217	36	C	C	NNP
cord-280878-1kt51viz	217	37	-	-	HYPH
cord-280878-1kt51viz	217	38	terminal	terminal	NN
cord-280878-1kt51viz	217	39	half	half	NN
cord-280878-1kt51viz	217	40	(	(	-LRB-
cord-280878-1kt51viz	217	41	TM2	TM2	NNP
cord-280878-1kt51viz	217	42	)	)	-RRB-
cord-280878-1kt51viz	217	43	of	of	IN
cord-280878-1kt51viz	217	44	p7	p7	NN
cord-280878-1kt51viz	217	45	.	.	.
cord-280878-1kt51viz	218	1	This	this	DT
cord-280878-1kt51viz	218	2	is	be	VBZ
cord-280878-1kt51viz	218	3	supported	support	VBN
cord-280878-1kt51viz	218	4	by	by	IN
cord-280878-1kt51viz	218	5	the	the	DT
cord-280878-1kt51viz	218	6	fact	fact	NN
cord-280878-1kt51viz	218	7	that	that	IN
cord-280878-1kt51viz	218	8	TM2	TM2	NNP
cord-280878-1kt51viz	218	9	of	of	IN
cord-280878-1kt51viz	218	10	p7	p7	NNP
cord-280878-1kt51viz	218	11	interacts	interact	VBZ
cord-280878-1kt51viz	218	12	with	with	IN
cord-280878-1kt51viz	218	13	Amt	Amt	NNP
cord-280878-1kt51viz	218	14	and	and	CC
cord-280878-1kt51viz	218	15	is	be	VBZ
cord-280878-1kt51viz	218	16	the	the	DT
cord-280878-1kt51viz	218	17	site	site	NN
cord-280878-1kt51viz	218	18	of	of	IN
cord-280878-1kt51viz	218	19	inhibition	inhibition	NN
cord-280878-1kt51viz	218	20	by	by	IN
cord-280878-1kt51viz	218	21	adamantanes	adamantane	NNS
cord-280878-1kt51viz	218	22	.	.	.
cord-280878-1kt51viz	219	1	Indeed	indeed	RB
cord-280878-1kt51viz	219	2	,	,	,
cord-280878-1kt51viz	219	3	Amt	Amt	NNP
cord-280878-1kt51viz	219	4	interacts	interact	VBZ
cord-280878-1kt51viz	219	5	with	with	IN
cord-280878-1kt51viz	219	6	leucines	leucine	NNS
cord-280878-1kt51viz	219	7	51	51	CD
cord-280878-1kt51viz	219	8	-	-	SYM
cord-280878-1kt51viz	219	9	57	57	CD
cord-280878-1kt51viz	219	10	,	,	,
cord-280878-1kt51viz	219	11	and	and	CC
cord-280878-1kt51viz	219	12	these	these	DT
cord-280878-1kt51viz	219	13	leucines	leucine	NNS
cord-280878-1kt51viz	219	14	have	have	VBP
cord-280878-1kt51viz	219	15	been	be	VBN
cord-280878-1kt51viz	219	16	shown	show	VBN
cord-280878-1kt51viz	219	17	unequivocally	unequivocally	RB
cord-280878-1kt51viz	219	18	to	to	TO
cord-280878-1kt51viz	219	19	be	be	VB
cord-280878-1kt51viz	219	20	part	part	NN
cord-280878-1kt51viz	219	21	of	of	IN
cord-280878-1kt51viz	219	22	a	a	DT
cord-280878-1kt51viz	219	23	membrane	membrane	NN
cord-280878-1kt51viz	219	24	inserted	insert	VBN
cord-280878-1kt51viz	219	25	α	α	NN
cord-280878-1kt51viz	219	26	-	-	HYPH
cord-280878-1kt51viz	219	27	helix	helix	NN
cord-280878-1kt51viz	219	28	(	(	-LRB-
cord-280878-1kt51viz	219	29	Cook	Cook	NNP
cord-280878-1kt51viz	219	30	&	&	CC
cord-280878-1kt51viz	219	31	Opella	Opella	NNP
cord-280878-1kt51viz	219	32	,	,	,
cord-280878-1kt51viz	219	33	2009	2009	CD
cord-280878-1kt51viz	219	34	;	;	.
cord-280878-1kt51viz	220	1	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	220	2	et	et	NNP
cord-280878-1kt51viz	220	3	al	al	NNP
cord-280878-1kt51viz	220	4	.	.	NNP
cord-280878-1kt51viz	220	5	,	,	,
cord-280878-1kt51viz	220	6	2013	2013	CD
cord-280878-1kt51viz	220	7	)	)	-RRB-
cord-280878-1kt51viz	220	8	.	.	.
cord-280878-1kt51viz	221	1	Binding	Binding	NNP
cord-280878-1kt51viz	221	2	of	of	IN
cord-280878-1kt51viz	221	3	Amt	Amt	NNP
cord-280878-1kt51viz	221	4	to	to	IN
cord-280878-1kt51viz	221	5	p7	p7	NN
cord-280878-1kt51viz	221	6	in	in	IN
cord-280878-1kt51viz	221	7	dihexanoylphosphatidylcholine	dihexanoylphosphatidylcholine	NN
cord-280878-1kt51viz	221	8	(	(	-LRB-
cord-280878-1kt51viz	221	9	DHPC	DHPC	NNP
cord-280878-1kt51viz	221	10	)	)	-RRB-
cord-280878-1kt51viz	221	11	micelles	micelle	NNS
cord-280878-1kt51viz	221	12	led	lead	VBD
cord-280878-1kt51viz	221	13	to	to	IN
cord-280878-1kt51viz	221	14	resonance	resonance	NN
cord-280878-1kt51viz	221	15	shifts	shift	NNS
cord-280878-1kt51viz	221	16	in	in	IN
cord-280878-1kt51viz	221	17	several	several	JJ
cord-280878-1kt51viz	221	18	residues	residue	NNS
cord-280878-1kt51viz	221	19	,	,	,
cord-280878-1kt51viz	221	20	some	some	DT
cord-280878-1kt51viz	221	21	of	of	IN
cord-280878-1kt51viz	221	22	which	which	WDT
cord-280878-1kt51viz	221	23	are	be	VBP
cord-280878-1kt51viz	221	24	the	the	DT
cord-280878-1kt51viz	221	25	leucines	leucine	NNS
cord-280878-1kt51viz	221	26	51	51	CD
cord-280878-1kt51viz	221	27	-	-	SYM
cord-280878-1kt51viz	221	28	57	57	CD
cord-280878-1kt51viz	221	29	(	(	-LRB-
cord-280878-1kt51viz	221	30	but	but	CC
cord-280878-1kt51viz	221	31	not	not	RB
cord-280878-1kt51viz	221	32	53	53	CD
cord-280878-1kt51viz	221	33	)	)	-RRB-
cord-280878-1kt51viz	221	34	,	,	,
cord-280878-1kt51viz	221	35	ie	ie	NNP
cord-280878-1kt51viz	221	36	,	,	,
cord-280878-1kt51viz	221	37	located	locate	VBN
cord-280878-1kt51viz	221	38	in	in	IN
cord-280878-1kt51viz	221	39	TM2	TM2	NNP
cord-280878-1kt51viz	221	40	(	(	-LRB-
cord-280878-1kt51viz	221	41	Cook	Cook	NNP
cord-280878-1kt51viz	221	42	&	&	CC
cord-280878-1kt51viz	221	43	Opella	Opella	NNP
cord-280878-1kt51viz	221	44	,	,	,
cord-280878-1kt51viz	221	45	2009	2009	CD
cord-280878-1kt51viz	221	46	)	)	-RRB-
cord-280878-1kt51viz	221	47	.	.	.
cord-280878-1kt51viz	222	1	Consistent	consistent	JJ
cord-280878-1kt51viz	222	2	with	with	IN
cord-280878-1kt51viz	222	3	this	this	DT
cord-280878-1kt51viz	222	4	,	,	,
cord-280878-1kt51viz	222	5	Leu	Leu	NNP
cord-280878-1kt51viz	222	6	to	to	IN
cord-280878-1kt51viz	222	7	Ala	Ala	NNP
cord-280878-1kt51viz	222	8	mutations	mutation	NNS
cord-280878-1kt51viz	222	9	at	at	IN
cord-280878-1kt51viz	222	10	this	this	DT
cord-280878-1kt51viz	222	11	region	region	NN
cord-280878-1kt51viz	222	12	produced	produce	VBD
cord-280878-1kt51viz	222	13	an	an	DT
cord-280878-1kt51viz	222	14	Amt	Amt	NNP
cord-280878-1kt51viz	222	15	-	-	HYPH
cord-280878-1kt51viz	222	16	resistant	resistant	JJ
cord-280878-1kt51viz	222	17	p7	p7	NN
cord-280878-1kt51viz	222	18	mutant	mutant	NN
cord-280878-1kt51viz	222	19	revealed	reveal	VBD
cord-280878-1kt51viz	222	20	using	use	VBG
cord-280878-1kt51viz	222	21	the	the	DT
cord-280878-1kt51viz	222	22	CF	cf	NN
cord-280878-1kt51viz	222	23	release	release	NN
cord-280878-1kt51viz	222	24	assay	assay	NN
cord-280878-1kt51viz	222	25	(	(	-LRB-
cord-280878-1kt51viz	222	26	StGelais	StGelais	NNP
cord-280878-1kt51viz	222	27	et	et	NNP
cord-280878-1kt51viz	222	28	al	al	NNP
cord-280878-1kt51viz	222	29	.	.	NNP
cord-280878-1kt51viz	222	30	,	,	,
cord-280878-1kt51viz	222	31	2009	2009	CD
cord-280878-1kt51viz	222	32	)	)	-RRB-
cord-280878-1kt51viz	222	33	.	.	.
cord-280878-1kt51viz	223	1	The	the	DT
cord-280878-1kt51viz	223	2	imino	imino	NN
cord-280878-1kt51viz	223	3	sugar	sugar	NN
cord-280878-1kt51viz	223	4	NN	NN	NNP
cord-280878-1kt51viz	223	5	-	-	HYPH
cord-280878-1kt51viz	223	6	DNJ	DNJ	NNP
cord-280878-1kt51viz	223	7	and	and	CC
cord-280878-1kt51viz	223	8	Rim	Rim	NNP
cord-280878-1kt51viz	223	9	inhibited	inhibit	VBD
cord-280878-1kt51viz	223	10	secreted	secrete	VBN
cord-280878-1kt51viz	223	11	infectivity	infectivity	NN
cord-280878-1kt51viz	223	12	in	in	IN
cord-280878-1kt51viz	223	13	Amt	Amt	NNP
cord-280878-1kt51viz	223	14	-	-	HYPH
cord-280878-1kt51viz	223	15	resistant	resistant	JJ
cord-280878-1kt51viz	223	16	JFH-1	JFH-1	NNP
cord-280878-1kt51viz	223	17	and	and	CC
cord-280878-1kt51viz	223	18	CON-1	CON-1	NNP
cord-280878-1kt51viz	223	19	/	/	SYM
cord-280878-1kt51viz	223	20	JFH-1c3	jfh-1c3	NN
cord-280878-1kt51viz	223	21	viruses	virus	NNS
cord-280878-1kt51viz	223	22	,	,	,
cord-280878-1kt51viz	223	23	whereas	whereas	IN
cord-280878-1kt51viz	223	24	mutation	mutation	NN
cord-280878-1kt51viz	223	25	L20F	l20f	RB
cord-280878-1kt51viz	223	26	conferred	confer	VBD
cord-280878-1kt51viz	223	27	resistance	resistance	NN
cord-280878-1kt51viz	223	28	to	to	IN
cord-280878-1kt51viz	223	29	rimantadine	rimantadine	NNP
cord-280878-1kt51viz	223	30	(	(	-LRB-
cord-280878-1kt51viz	223	31	Foster	Foster	NNP
cord-280878-1kt51viz	223	32	et	et	NNP
cord-280878-1kt51viz	223	33	al	al	NNP
cord-280878-1kt51viz	223	34	.	.	NNP
cord-280878-1kt51viz	223	35	,	,	,
cord-280878-1kt51viz	223	36	2011	2011	CD
cord-280878-1kt51viz	223	37	)	)	-RRB-
cord-280878-1kt51viz	223	38	,	,	,
cord-280878-1kt51viz	223	39	consistent	consistent	JJ
cord-280878-1kt51viz	223	40	with	with	IN
cord-280878-1kt51viz	223	41	Rim	Rim	NNP
cord-280878-1kt51viz	223	42	resistance	resistance	NN
cord-280878-1kt51viz	223	43	was	be	VBD
cord-280878-1kt51viz	223	44	found	find	VBN
cord-280878-1kt51viz	223	45	in	in	IN
cord-280878-1kt51viz	223	46	GT1b	GT1b	NNP
cord-280878-1kt51viz	223	47	patients	patient	NNS
cord-280878-1kt51viz	223	48	not	not	RB
cord-280878-1kt51viz	223	49	responding	respond	VBG
cord-280878-1kt51viz	223	50	to	to	IN
cord-280878-1kt51viz	223	51	the	the	DT
cord-280878-1kt51viz	223	52	triple	triple	JJ
cord-280878-1kt51viz	223	53	therapy	therapy	NN
cord-280878-1kt51viz	223	54	IFN	IFN	NNP
cord-280878-1kt51viz	223	55	/	/	SYM
cord-280878-1kt51viz	223	56	Rib	Rib	NNP
cord-280878-1kt51viz	223	57	/	/	SYM
cord-280878-1kt51viz	223	58	Amt	Amt	NNP
cord-280878-1kt51viz	223	59	(	(	-LRB-
cord-280878-1kt51viz	223	60	Mihm	Mihm	NNP
cord-280878-1kt51viz	223	61	et	et	NNP
cord-280878-1kt51viz	223	62	al	al	NNP
cord-280878-1kt51viz	223	63	.	.	NNP
cord-280878-1kt51viz	223	64	,	,	,
cord-280878-1kt51viz	223	65	2006	2006	CD
cord-280878-1kt51viz	223	66	)	)	-RRB-
cord-280878-1kt51viz	223	67	.	.	.
cord-280878-1kt51viz	224	1	Using	use	VBG
cord-280878-1kt51viz	224	2	an	an	DT
cord-280878-1kt51viz	224	3	oligomerization	oligomerization	NN
cord-280878-1kt51viz	224	4	assay	assay	NN
cord-280878-1kt51viz	224	5	in	in	IN
cord-280878-1kt51viz	224	6	DHPC	DHPC	NNP
cord-280878-1kt51viz	224	7	gels	gel	NNS
cord-280878-1kt51viz	224	8	,	,	,
cord-280878-1kt51viz	224	9	the	the	DT
cord-280878-1kt51viz	224	10	GT1b	GT1b	NNP
cord-280878-1kt51viz	224	11	J4	J4	NNP
cord-280878-1kt51viz	224	12	p7	p7	NN
cord-280878-1kt51viz	224	13	oligomerization	oligomerization	NN
cord-280878-1kt51viz	224	14	was	be	VBD
cord-280878-1kt51viz	224	15	abolished	abolish	VBN
cord-280878-1kt51viz	224	16	in	in	IN
cord-280878-1kt51viz	224	17	presence	presence	NN
cord-280878-1kt51viz	224	18	of	of	IN
cord-280878-1kt51viz	224	19	imino	imino	NN
cord-280878-1kt51viz	224	20	-	-	HYPH
cord-280878-1kt51viz	224	21	sugars	sugar	NNS
cord-280878-1kt51viz	224	22	,	,	,
cord-280878-1kt51viz	224	23	whereas	whereas	IN
cord-280878-1kt51viz	224	24	Rim	Rim	NNP
cord-280878-1kt51viz	224	25	did	do	VBD
cord-280878-1kt51viz	224	26	not	not	RB
cord-280878-1kt51viz	224	27	affect	affect	VB
cord-280878-1kt51viz	224	28	oligomerization	oligomerization	NN
cord-280878-1kt51viz	224	29	,	,	,
cord-280878-1kt51viz	224	30	suggesting	suggest	VBG
cord-280878-1kt51viz	224	31	two	two	CD
cord-280878-1kt51viz	224	32	different	different	JJ
cord-280878-1kt51viz	224	33	mechanisms	mechanism	NNS
cord-280878-1kt51viz	224	34	of	of	IN
cord-280878-1kt51viz	224	35	action	action	NN
cord-280878-1kt51viz	224	36	for	for	IN
cord-280878-1kt51viz	224	37	these	these	DT
cord-280878-1kt51viz	224	38	two	two	CD
cord-280878-1kt51viz	224	39	compounds	compound	NNS
cord-280878-1kt51viz	224	40	(	(	-LRB-
cord-280878-1kt51viz	224	41	Foster	Foster	NNP
cord-280878-1kt51viz	224	42	et	et	NNP
cord-280878-1kt51viz	224	43	al	al	NNP
cord-280878-1kt51viz	224	44	.	.	NNP
cord-280878-1kt51viz	224	45	,	,	,
cord-280878-1kt51viz	224	46	2011	2011	CD
cord-280878-1kt51viz	224	47	)	)	-RRB-
cord-280878-1kt51viz	224	48	.	.	.
cord-280878-1kt51viz	225	1	The	the	DT
cord-280878-1kt51viz	225	2	p7	p7	NN
cord-280878-1kt51viz	225	3	of	of	IN
cord-280878-1kt51viz	225	4	GT3a	GT3a	NNP
cord-280878-1kt51viz	225	5	,	,	,
cord-280878-1kt51viz	225	6	but	but	CC
cord-280878-1kt51viz	225	7	not	not	RB
cord-280878-1kt51viz	225	8	GT1b	GT1b	NNP
cord-280878-1kt51viz	225	9	,	,	,
cord-280878-1kt51viz	225	10	was	be	VBD
cord-280878-1kt51viz	225	11	found	find	VBN
cord-280878-1kt51viz	225	12	to	to	TO
cord-280878-1kt51viz	225	13	be	be	VB
cord-280878-1kt51viz	225	14	resistant	resistant	JJ
cord-280878-1kt51viz	225	15	to	to	IN
cord-280878-1kt51viz	225	16	NN	NN	NNP
cord-280878-1kt51viz	225	17	-	-	HYPH
cord-280878-1kt51viz	225	18	DNJ	DNJ	NNP
cord-280878-1kt51viz	225	19	both	both	DT
cord-280878-1kt51viz	225	20	in	in	IN
cord-280878-1kt51viz	225	21	vitro	vitro	FW
cord-280878-1kt51viz	225	22	and	and	CC
cord-280878-1kt51viz	225	23	in	in	IN
cord-280878-1kt51viz	225	24	culture	culture	NN
cord-280878-1kt51viz	225	25	,	,	,
cord-280878-1kt51viz	225	26	and	and	CC
cord-280878-1kt51viz	225	27	this	this	DT
cord-280878-1kt51viz	225	28	was	be	VBD
cord-280878-1kt51viz	225	29	attributed	attribute	VBN
cord-280878-1kt51viz	225	30	to	to	IN
cord-280878-1kt51viz	225	31	a	a	DT
cord-280878-1kt51viz	225	32	F25A	f25a	NN
cord-280878-1kt51viz	225	33	mutation	mutation	NN
cord-280878-1kt51viz	225	34	(	(	-LRB-
cord-280878-1kt51viz	225	35	Foster	Foster	NNP
cord-280878-1kt51viz	225	36	et	et	NNP
cord-280878-1kt51viz	225	37	al	al	NNP
cord-280878-1kt51viz	225	38	.	.	NNP
cord-280878-1kt51viz	225	39	,	,	,
cord-280878-1kt51viz	225	40	2011	2011	CD
cord-280878-1kt51viz	225	41	;	;	:
cord-280878-1kt51viz	225	42	Griffin	Griffin	NNP
cord-280878-1kt51viz	225	43	et	et	NNP
cord-280878-1kt51viz	225	44	al	al	NNP
cord-280878-1kt51viz	225	45	.	.	NNP
cord-280878-1kt51viz	225	46	,	,	,
cord-280878-1kt51viz	225	47	2008	2008	CD
cord-280878-1kt51viz	225	48	)	)	-RRB-
cord-280878-1kt51viz	225	49	.	.	.
cord-280878-1kt51viz	226	1	However	however	RB
cord-280878-1kt51viz	226	2	,	,	,
cord-280878-1kt51viz	226	3	direct	direct	JJ
cord-280878-1kt51viz	226	4	interaction	interaction	NN
cord-280878-1kt51viz	226	5	between	between	IN
cord-280878-1kt51viz	226	6	HMA	HMA	NNP
cord-280878-1kt51viz	226	7	or	or	CC
cord-280878-1kt51viz	226	8	imino	imino	NNP
cord-280878-1kt51viz	226	9	sugar	sugar	NN
cord-280878-1kt51viz	226	10	derivatives	derivative	NNS
cord-280878-1kt51viz	226	11	with	with	IN
cord-280878-1kt51viz	226	12	p7	p7	NN
cord-280878-1kt51viz	226	13	reconstituted	reconstitute	VBN
cord-280878-1kt51viz	226	14	in	in	IN
cord-280878-1kt51viz	226	15	a	a	DT
cord-280878-1kt51viz	226	16	detergent	detergent	NN
cord-280878-1kt51viz	226	17	or	or	CC
cord-280878-1kt51viz	226	18	membrane	membrane	NN
cord-280878-1kt51viz	226	19	has	have	VBZ
cord-280878-1kt51viz	226	20	not	not	RB
cord-280878-1kt51viz	226	21	been	be	VBN
cord-280878-1kt51viz	226	22	reported	report	VBN
cord-280878-1kt51viz	226	23	.	.	.
cord-280878-1kt51viz	227	1	Addition	addition	NN
cord-280878-1kt51viz	227	2	of	of	IN
cord-280878-1kt51viz	227	3	Rim	Rim	NNP
cord-280878-1kt51viz	227	4	to	to	IN
cord-280878-1kt51viz	227	5	GT1b	GT1b	NNP
cord-280878-1kt51viz	227	6	J4	J4	NNP
cord-280878-1kt51viz	227	7	p7	p7	NN
cord-280878-1kt51viz	227	8	monomer	monomer	NN
cord-280878-1kt51viz	227	9	in	in	IN
cord-280878-1kt51viz	227	10	methanol	methanol	NN
cord-280878-1kt51viz	228	1	(	(	-LRB-
cord-280878-1kt51viz	228	2	Foster	Foster	NNP
cord-280878-1kt51viz	228	3	et	et	NNP
cord-280878-1kt51viz	228	4	al	al	NNP
cord-280878-1kt51viz	228	5	.	.	NNP
cord-280878-1kt51viz	228	6	,	,	,
cord-280878-1kt51viz	228	7	2014	2014	CD
cord-280878-1kt51viz	228	8	)	)	-RRB-
cord-280878-1kt51viz	228	9	showed	show	VBD
cord-280878-1kt51viz	228	10	disruption	disruption	NN
cord-280878-1kt51viz	228	11	at	at	IN
cord-280878-1kt51viz	228	12	several	several	JJ
cord-280878-1kt51viz	228	13	residues	residue	NNS
cord-280878-1kt51viz	228	14	,	,	,
cord-280878-1kt51viz	228	15	but	but	CC
cord-280878-1kt51viz	228	16	not	not	RB
cord-280878-1kt51viz	228	17	especially	especially	RB
cord-280878-1kt51viz	228	18	at	at	IN
cord-280878-1kt51viz	228	19	Leu-20	Leu-20	NNP
cord-280878-1kt51viz	228	20	.	.	.
cord-280878-1kt51viz	229	1	Thus	thus	RB
cord-280878-1kt51viz	229	2	,	,	,
cord-280878-1kt51viz	229	3	this	this	DT
cord-280878-1kt51viz	229	4	observation	observation	NN
cord-280878-1kt51viz	229	5	is	be	VBZ
cord-280878-1kt51viz	229	6	either	either	CC
cord-280878-1kt51viz	229	7	inconsistent	inconsistent	JJ
cord-280878-1kt51viz	229	8	with	with	IN
cord-280878-1kt51viz	229	9	the	the	DT
cord-280878-1kt51viz	229	10	proposed	propose	VBN
cord-280878-1kt51viz	229	11	role	role	NN
cord-280878-1kt51viz	229	12	of	of	IN
cord-280878-1kt51viz	229	13	L20F	l20f	RB
cord-280878-1kt51viz	229	14	in	in	IN
cord-280878-1kt51viz	229	15	acquired	acquire	VBN
cord-280878-1kt51viz	229	16	resistance	resistance	NN
cord-280878-1kt51viz	229	17	,	,	,
cord-280878-1kt51viz	229	18	or	or	CC
cord-280878-1kt51viz	229	19	the	the	DT
cord-280878-1kt51viz	229	20	methanol	methanol	NN
cord-280878-1kt51viz	229	21	environment	environment	NN
cord-280878-1kt51viz	229	22	is	be	VBZ
cord-280878-1kt51viz	229	23	not	not	RB
cord-280878-1kt51viz	229	24	a	a	DT
cord-280878-1kt51viz	229	25	good	good	JJ
cord-280878-1kt51viz	229	26	system	system	NN
cord-280878-1kt51viz	229	27	to	to	TO
cord-280878-1kt51viz	229	28	test	test	VB
cord-280878-1kt51viz	229	29	this	this	DT
cord-280878-1kt51viz	229	30	interaction	interaction	NN
cord-280878-1kt51viz	229	31	.	.	.
cord-280878-1kt51viz	230	1	Structural	structural	JJ
cord-280878-1kt51viz	230	2	data	datum	NNS
cord-280878-1kt51viz	230	3	for	for	IN
cord-280878-1kt51viz	230	4	p7	p7	NN
cord-280878-1kt51viz	230	5	was	be	VBD
cord-280878-1kt51viz	230	6	obtained	obtain	VBN
cord-280878-1kt51viz	230	7	initially	initially	RB
cord-280878-1kt51viz	230	8	in	in	IN
cord-280878-1kt51viz	230	9	solvents	solvent	NNS
cord-280878-1kt51viz	230	10	and	and	CC
cord-280878-1kt51viz	230	11	micelles	micelle	NNS
cord-280878-1kt51viz	230	12	by	by	IN
cord-280878-1kt51viz	230	13	solution	solution	NN
cord-280878-1kt51viz	230	14	NMR	nmr	NN
cord-280878-1kt51viz	230	15	.	.	.
cord-280878-1kt51viz	231	1	For	for	IN
cord-280878-1kt51viz	231	2	example	example	NN
cord-280878-1kt51viz	231	3	,	,	,
cord-280878-1kt51viz	231	4	solution	solution	NN
cord-280878-1kt51viz	231	5	NMR	NMR	NNP
cord-280878-1kt51viz	231	6	data	datum	NNS
cord-280878-1kt51viz	231	7	was	be	VBD
cord-280878-1kt51viz	231	8	obtained	obtain	VBN
cord-280878-1kt51viz	231	9	for	for	IN
cord-280878-1kt51viz	231	10	synthetic	synthetic	JJ
cord-280878-1kt51viz	231	11	p7	p7	NN
cord-280878-1kt51viz	231	12	(	(	-LRB-
cord-280878-1kt51viz	231	13	C27A	C27A	NNS
cord-280878-1kt51viz	231	14	mutant	mutant	JJ
cord-280878-1kt51viz	231	15	)	)	-RRB-
cord-280878-1kt51viz	231	16	in	in	IN
cord-280878-1kt51viz	231	17	50	50	CD
cord-280878-1kt51viz	231	18	%	%	NN
cord-280878-1kt51viz	231	19	of	of	IN
cord-280878-1kt51viz	231	20	the	the	DT
cord-280878-1kt51viz	231	21	helix	helix	NN
cord-280878-1kt51viz	231	22	inducer	inducer	NN
cord-280878-1kt51viz	231	23	trifluoroethanol	trifluoroethanol	NNP
cord-280878-1kt51viz	231	24	(	(	-LRB-
cord-280878-1kt51viz	231	25	TFE	TFE	NNP
cord-280878-1kt51viz	231	26	)	)	-RRB-
cord-280878-1kt51viz	232	1	(	(	-LRB-
cord-280878-1kt51viz	232	2	Montserret	Montserret	NNP
cord-280878-1kt51viz	232	3	et	et	NNP
cord-280878-1kt51viz	232	4	al	al	NNP
cord-280878-1kt51viz	232	5	.	.	NNP
cord-280878-1kt51viz	232	6	,	,	,
cord-280878-1kt51viz	232	7	2010	2010	CD
cord-280878-1kt51viz	232	8	)	)	-RRB-
cord-280878-1kt51viz	232	9	,	,	,
cord-280878-1kt51viz	232	10	and	and	CC
cord-280878-1kt51viz	232	11	for	for	IN
cord-280878-1kt51viz	232	12	recombinant	recombinant	JJ
cord-280878-1kt51viz	232	13	p7	p7	NN
cord-280878-1kt51viz	232	14	(	(	-LRB-
cord-280878-1kt51viz	232	15	C27S	C27S	NNP
cord-280878-1kt51viz	232	16	mutant	mutant	JJ
cord-280878-1kt51viz	232	17	)	)	-RRB-
cord-280878-1kt51viz	232	18	in	in	IN
cord-280878-1kt51viz	232	19	DHPC	DHPC	NNP
cord-280878-1kt51viz	232	20	micelles	micelle	NNS
cord-280878-1kt51viz	232	21	)	)	-RRB-
cord-280878-1kt51viz	232	22	.	.	.
cord-280878-1kt51viz	233	1	The	the	DT
cord-280878-1kt51viz	233	2	prevalent	prevalent	JJ
cord-280878-1kt51viz	233	3	model	model	NN
cord-280878-1kt51viz	233	4	for	for	IN
cord-280878-1kt51viz	233	5	the	the	DT
cord-280878-1kt51viz	233	6	p7	p7	NN
cord-280878-1kt51viz	233	7	monomer	monomer	NN
cord-280878-1kt51viz	233	8	according	accord	VBG
cord-280878-1kt51viz	233	9	to	to	IN
cord-280878-1kt51viz	233	10	these	these	DT
cord-280878-1kt51viz	233	11	studies	study	NNS
cord-280878-1kt51viz	233	12	was	be	VBD
cord-280878-1kt51viz	233	13	that	that	DT
cord-280878-1kt51viz	233	14	of	of	IN
cord-280878-1kt51viz	233	15	an	an	DT
cord-280878-1kt51viz	233	16	α	α	XX
cord-280878-1kt51viz	233	17	-	-	HYPH
cord-280878-1kt51viz	233	18	helical	helical	JJ
cord-280878-1kt51viz	233	19	hairpin	hairpin	NN
cord-280878-1kt51viz	233	20	with	with	IN
cord-280878-1kt51viz	233	21	two	two	CD
cord-280878-1kt51viz	233	22	α	α	NN
cord-280878-1kt51viz	233	23	-	-	HYPH
cord-280878-1kt51viz	233	24	helical	helical	JJ
cord-280878-1kt51viz	233	25	TMs	tms	NN
cord-280878-1kt51viz	233	26	kinked	kink	VBN
cord-280878-1kt51viz	233	27	in	in	IN
cord-280878-1kt51viz	233	28	the	the	DT
cord-280878-1kt51viz	233	29	middle	middle	NN
cord-280878-1kt51viz	233	30	(	(	-LRB-
cord-280878-1kt51viz	233	31	Cook	Cook	NNP
cord-280878-1kt51viz	233	32	,	,	,
cord-280878-1kt51viz	233	33	Zhang	Zhang	NNP
cord-280878-1kt51viz	233	34	,	,	,
cord-280878-1kt51viz	233	35	Park	Park	NNP
cord-280878-1kt51viz	233	36	,	,	,
cord-280878-1kt51viz	233	37	Wang	Wang	NNP
cord-280878-1kt51viz	233	38	,	,	,
cord-280878-1kt51viz	233	39	&	&	CC
cord-280878-1kt51viz	233	40	Opella	Opella	NNP
cord-280878-1kt51viz	233	41	,	,	,
cord-280878-1kt51viz	233	42	2010	2010	CD
cord-280878-1kt51viz	233	43	;	;	:
cord-280878-1kt51viz	233	44	Montserret	Montserret	NNP
cord-280878-1kt51viz	233	45	et	et	NNP
cord-280878-1kt51viz	233	46	al	al	NNP
cord-280878-1kt51viz	233	47	.	.	NNP
cord-280878-1kt51viz	233	48	,	,	,
cord-280878-1kt51viz	233	49	2010	2010	CD
cord-280878-1kt51viz	233	50	)	)	-RRB-
cord-280878-1kt51viz	233	51	,	,	,
cord-280878-1kt51viz	233	52	where	where	WRB
cord-280878-1kt51viz	233	53	the	the	DT
cord-280878-1kt51viz	233	54	N	n	CD
cord-280878-1kt51viz	233	55	-	-	HYPH
cord-280878-1kt51viz	233	56	terminal	terminal	NN
cord-280878-1kt51viz	233	57	TM	TM	NNP
cord-280878-1kt51viz	233	58	helix	helix	NN
cord-280878-1kt51viz	233	59	(	(	-LRB-
cord-280878-1kt51viz	233	60	TM1	TM1	NNP
cord-280878-1kt51viz	233	61	)	)	-RRB-
cord-280878-1kt51viz	233	62	would	would	MD
cord-280878-1kt51viz	233	63	face	face	VB
cord-280878-1kt51viz	233	64	the	the	DT
cord-280878-1kt51viz	233	65	lumen	lumen	NN
cord-280878-1kt51viz	233	66	of	of	IN
cord-280878-1kt51viz	233	67	a	a	DT
cord-280878-1kt51viz	233	68	channel	channel	NN
cord-280878-1kt51viz	234	1	(	(	-LRB-
cord-280878-1kt51viz	234	2	Carrere	Carrere	NNP
cord-280878-1kt51viz	234	3	-	-	HYPH
cord-280878-1kt51viz	234	4	Kremer	Kremer	NNP
cord-280878-1kt51viz	234	5	et	et	NNP
cord-280878-1kt51viz	234	6	al	al	NNP
cord-280878-1kt51viz	234	7	.	.	NNP
cord-280878-1kt51viz	234	8	,	,	,
cord-280878-1kt51viz	234	9	2002	2002	CD
cord-280878-1kt51viz	234	10	;	;	:
cord-280878-1kt51viz	234	11	Chew	chew	VB
cord-280878-1kt51viz	234	12	,	,	,
cord-280878-1kt51viz	234	13	Vijayan	Vijayan	NNP
cord-280878-1kt51viz	234	14	,	,	,
cord-280878-1kt51viz	234	15	Chang	Chang	NNP
cord-280878-1kt51viz	234	16	,	,	,
cord-280878-1kt51viz	234	17	Zitzmann	Zitzmann	NNP
cord-280878-1kt51viz	234	18	,	,	,
cord-280878-1kt51viz	234	19	&	&	CC
cord-280878-1kt51viz	234	20	Biggin	Biggin	NNP
cord-280878-1kt51viz	234	21	,	,	,
cord-280878-1kt51viz	234	22	2009	2009	CD
cord-280878-1kt51viz	234	23	;	;	:
cord-280878-1kt51viz	234	24	Patargias	Patargias	NNP
cord-280878-1kt51viz	234	25	,	,	,
cord-280878-1kt51viz	234	26	Zitzmann	Zitzmann	NNP
cord-280878-1kt51viz	234	27	,	,	,
cord-280878-1kt51viz	234	28	Dwek	Dwek	NNP
cord-280878-1kt51viz	234	29	,	,	,
cord-280878-1kt51viz	234	30	&	&	CC
cord-280878-1kt51viz	234	31	Fischer	Fischer	NNP
cord-280878-1kt51viz	234	32	,	,	,
cord-280878-1kt51viz	234	33	2006	2006	CD
cord-280878-1kt51viz	234	34	)	)	-RRB-
cord-280878-1kt51viz	234	35	formed	form	VBN
cord-280878-1kt51viz	234	36	by	by	IN
cord-280878-1kt51viz	234	37	either	either	DT
cord-280878-1kt51viz	234	38	six	six	CD
cord-280878-1kt51viz	234	39	or	or	CC
cord-280878-1kt51viz	234	40	seven	seven	CD
cord-280878-1kt51viz	234	41	monomers	monomer	NNS
cord-280878-1kt51viz	234	42	(	(	-LRB-
cord-280878-1kt51viz	234	43	Clarke	Clarke	NNP
cord-280878-1kt51viz	234	44	et	et	NNP
cord-280878-1kt51viz	234	45	al	al	NNP
cord-280878-1kt51viz	234	46	.	.	NNP
cord-280878-1kt51viz	234	47	,	,	,
cord-280878-1kt51viz	234	48	2006	2006	CD
cord-280878-1kt51viz	234	49	;	;	:
cord-280878-1kt51viz	234	50	Griffin	Griffin	NNP
cord-280878-1kt51viz	234	51	et	et	NNP
cord-280878-1kt51viz	234	52	al	al	NNP
cord-280878-1kt51viz	234	53	.	.	NNP
cord-280878-1kt51viz	234	54	,	,	,
cord-280878-1kt51viz	234	55	2003	2003	CD
cord-280878-1kt51viz	234	56	;	;	:
cord-280878-1kt51viz	234	57	Luik	Luik	NNP
cord-280878-1kt51viz	234	58	et	et	FW
cord-280878-1kt51viz	234	59	al	al	NNP
cord-280878-1kt51viz	234	60	.	.	NNP
cord-280878-1kt51viz	234	61	,	,	,
cord-280878-1kt51viz	234	62	2009	2009	CD
cord-280878-1kt51viz	234	63	;	;	:
cord-280878-1kt51viz	234	64	Montserret	Montserret	NNP
cord-280878-1kt51viz	234	65	et	et	NNP
cord-280878-1kt51viz	234	66	al	al	NNP
cord-280878-1kt51viz	234	67	.	.	NNP
cord-280878-1kt51viz	234	68	,	,	,
cord-280878-1kt51viz	234	69	2010	2010	CD
cord-280878-1kt51viz	234	70	)	)	-RRB-
cord-280878-1kt51viz	234	71	.	.	.
cord-280878-1kt51viz	235	1	In	in	IN
cord-280878-1kt51viz	235	2	a	a	DT
cord-280878-1kt51viz	235	3	more	more	RBR
cord-280878-1kt51viz	235	4	recently	recently	RB
cord-280878-1kt51viz	235	5	published	publish	VBN
cord-280878-1kt51viz	235	6	structural	structural	JJ
cord-280878-1kt51viz	235	7	model	model	NN
cord-280878-1kt51viz	235	8	of	of	IN
cord-280878-1kt51viz	235	9	p7	p7	NN
cord-280878-1kt51viz	236	1	(	(	-LRB-
cord-280878-1kt51viz	236	2	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	236	3	et	et	NNP
cord-280878-1kt51viz	236	4	al	al	NNP
cord-280878-1kt51viz	236	5	.	.	NNP
cord-280878-1kt51viz	236	6	,	,	,
cord-280878-1kt51viz	236	7	2013	2013	CD
cord-280878-1kt51viz	236	8	)	)	-RRB-
cord-280878-1kt51viz	236	9	,	,	,
cord-280878-1kt51viz	236	10	the	the	DT
cord-280878-1kt51viz	236	11	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	236	12	size	size	NN
cord-280878-1kt51viz	236	13	is	be	VBZ
cord-280878-1kt51viz	236	14	still	still	RB
cord-280878-1kt51viz	236	15	ambiguous	ambiguous	JJ
cord-280878-1kt51viz	236	16	since	since	IN
cord-280878-1kt51viz	236	17	this	this	DT
cord-280878-1kt51viz	236	18	data	data	NN
cord-280878-1kt51viz	236	19	could	could	MD
cord-280878-1kt51viz	236	20	not	not	RB
cord-280878-1kt51viz	236	21	be	be	VB
cord-280878-1kt51viz	236	22	obtained	obtain	VBN
cord-280878-1kt51viz	236	23	in	in	IN
cord-280878-1kt51viz	236	24	the	the	DT
cord-280878-1kt51viz	236	25	same	same	JJ
cord-280878-1kt51viz	236	26	environment	environment	NN
cord-280878-1kt51viz	236	27	used	use	VBN
cord-280878-1kt51viz	236	28	in	in	IN
cord-280878-1kt51viz	236	29	electron	electron	NN
cord-280878-1kt51viz	236	30	microscopy	microscopy	NN
cord-280878-1kt51viz	236	31	.	.	.
cord-280878-1kt51viz	237	1	From	from	IN
cord-280878-1kt51viz	237	2	that	that	DT
cord-280878-1kt51viz	237	3	model	model	NN
cord-280878-1kt51viz	237	4	,	,	,
cord-280878-1kt51viz	237	5	the	the	DT
cord-280878-1kt51viz	237	6	"	"	``
cord-280878-1kt51viz	237	7	old	old	JJ
cord-280878-1kt51viz	237	8	"	"	''
cord-280878-1kt51viz	237	9	TM1	TM1	NNP
cord-280878-1kt51viz	237	10	and	and	CC
cord-280878-1kt51viz	237	11	TM2	TM2	NNP
cord-280878-1kt51viz	237	12	domains	domain	NNS
cord-280878-1kt51viz	237	13	would	would	MD
cord-280878-1kt51viz	237	14	correspond	correspond	VB
cord-280878-1kt51viz	237	15	to	to	IN
cord-280878-1kt51viz	237	16	three	three	CD
cord-280878-1kt51viz	237	17	helical	helical	JJ
cord-280878-1kt51viz	237	18	segments	segment	NNS
cord-280878-1kt51viz	238	1	H1-H3	H1-H3	NNP
cord-280878-1kt51viz	238	2	,	,	,
cord-280878-1kt51viz	238	3	ie	ie	NNS
cord-280878-1kt51viz	238	4	,	,	,
cord-280878-1kt51viz	238	5	H1	h1	NN
cord-280878-1kt51viz	238	6	and	and	CC
cord-280878-1kt51viz	238	7	first	first	JJ
cord-280878-1kt51viz	238	8	half	half	NN
cord-280878-1kt51viz	238	9	of	of	IN
cord-280878-1kt51viz	238	10	H2	H2	NNP
cord-280878-1kt51viz	238	11	(	(	-LRB-
cord-280878-1kt51viz	238	12	TM1	TM1	NNP
cord-280878-1kt51viz	238	13	)	)	-RRB-
cord-280878-1kt51viz	238	14	and	and	CC
cord-280878-1kt51viz	238	15	second	second	JJ
cord-280878-1kt51viz	238	16	half	half	NN
cord-280878-1kt51viz	238	17	of	of	IN
cord-280878-1kt51viz	238	18	H2	H2	NNP
cord-280878-1kt51viz	238	19	and	and	CC
cord-280878-1kt51viz	238	20	H3	H3	NNP
cord-280878-1kt51viz	238	21	(	(	-LRB-
cord-280878-1kt51viz	238	22	TM2	TM2	NNP
cord-280878-1kt51viz	238	23	)	)	-RRB-
cord-280878-1kt51viz	238	24	.	.	.
cord-280878-1kt51viz	239	1	There	there	EX
cord-280878-1kt51viz	239	2	are	be	VBP
cord-280878-1kt51viz	239	3	concerns	concern	NNS
cord-280878-1kt51viz	239	4	,	,	,
cord-280878-1kt51viz	239	5	however	however	RB
cord-280878-1kt51viz	239	6	,	,	,
cord-280878-1kt51viz	239	7	that	that	IN
cord-280878-1kt51viz	239	8	this	this	DT
cord-280878-1kt51viz	239	9	model	model	NN
cord-280878-1kt51viz	239	10	can	can	MD
cord-280878-1kt51viz	239	11	be	be	VB
cord-280878-1kt51viz	239	12	present	present	JJ
cord-280878-1kt51viz	239	13	in	in	IN
cord-280878-1kt51viz	239	14	a	a	DT
cord-280878-1kt51viz	239	15	physiological	physiological	JJ
cord-280878-1kt51viz	239	16	context	context	NN
cord-280878-1kt51viz	239	17	since	since	IN
cord-280878-1kt51viz	239	18	the	the	DT
cord-280878-1kt51viz	239	19	folding	folding	NN
cord-280878-1kt51viz	239	20	implied	imply	VBN
cord-280878-1kt51viz	239	21	is	be	VBZ
cord-280878-1kt51viz	239	22	difficult	difficult	JJ
cord-280878-1kt51viz	239	23	to	to	TO
cord-280878-1kt51viz	239	24	explain	explain	VB
cord-280878-1kt51viz	239	25	by	by	IN
cord-280878-1kt51viz	239	26	our	-PRON-	PRP$
cord-280878-1kt51viz	239	27	current	current	JJ
cord-280878-1kt51viz	239	28	understanding	understanding	NN
cord-280878-1kt51viz	239	29	of	of	IN
cord-280878-1kt51viz	239	30	protein	protein	NN
cord-280878-1kt51viz	239	31	folding	folding	NN
cord-280878-1kt51viz	239	32	in	in	IN
cord-280878-1kt51viz	239	33	the	the	DT
cord-280878-1kt51viz	239	34	cell	cell	NN
cord-280878-1kt51viz	239	35	(	(	-LRB-
cord-280878-1kt51viz	239	36	Madan	Madan	NNP
cord-280878-1kt51viz	239	37	&	&	CC
cord-280878-1kt51viz	239	38	Bartenschlager	Bartenschlager	NNP
cord-280878-1kt51viz	239	39	,	,	,
cord-280878-1kt51viz	239	40	2015	2015	CD
cord-280878-1kt51viz	239	41	)	)	-RRB-
cord-280878-1kt51viz	239	42	.	.	.
cord-280878-1kt51viz	240	1	In	in	IN
cord-280878-1kt51viz	240	2	the	the	DT
cord-280878-1kt51viz	240	3	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	240	4	et	et	NNP
cord-280878-1kt51viz	240	5	al	al	NNP
cord-280878-1kt51viz	240	6	.	.	.
cord-280878-1kt51viz	240	7	paper	paper	NNP
cord-280878-1kt51viz	240	8	,	,	,
cord-280878-1kt51viz	240	9	the	the	DT
cord-280878-1kt51viz	240	10	authors	author	NNS
cord-280878-1kt51viz	240	11	systematically	systematically	RB
cord-280878-1kt51viz	240	12	tested	test	VBD
cord-280878-1kt51viz	240	13	p7	p7	RB
cord-280878-1kt51viz	240	14	amino	amino	NN
cord-280878-1kt51viz	240	15	acid	acid	NN
cord-280878-1kt51viz	240	16	sequences	sequence	NNS
cord-280878-1kt51viz	240	17	from	from	IN
cord-280878-1kt51viz	240	18	various	various	JJ
cord-280878-1kt51viz	240	19	HCV	HCV	NNP
cord-280878-1kt51viz	240	20	genotypes	genotype	NNS
cord-280878-1kt51viz	240	21	and	and	CC
cord-280878-1kt51viz	240	22	found	find	VBD
cord-280878-1kt51viz	240	23	that	that	IN
cord-280878-1kt51viz	240	24	the	the	DT
cord-280878-1kt51viz	240	25	sequence	sequence	NN
cord-280878-1kt51viz	240	26	from	from	IN
cord-280878-1kt51viz	240	27	GT5a	GT5a	NNP
cord-280878-1kt51viz	240	28	(	(	-LRB-
cord-280878-1kt51viz	240	29	EUH1480	EUH1480	NNP
cord-280878-1kt51viz	240	30	strain	strain	NN
cord-280878-1kt51viz	240	31	)	)	-RRB-
cord-280878-1kt51viz	240	32	generated	generate	VBN
cord-280878-1kt51viz	240	33	samples	sample	NNS
cord-280878-1kt51viz	240	34	adequate	adequate	JJ
cord-280878-1kt51viz	240	35	for	for	IN
cord-280878-1kt51viz	240	36	structure	structure	NN
cord-280878-1kt51viz	240	37	determination	determination	NN
cord-280878-1kt51viz	240	38	.	.	.
cord-280878-1kt51viz	241	1	Although	although	IN
cord-280878-1kt51viz	241	2	the	the	DT
cord-280878-1kt51viz	241	3	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	241	4	size	size	NN
cord-280878-1kt51viz	241	5	of	of	IN
cord-280878-1kt51viz	241	6	p7	p7	NN
cord-280878-1kt51viz	241	7	in	in	IN
cord-280878-1kt51viz	241	8	dodecyl	dodecyl	NNP
cord-280878-1kt51viz	241	9	phosphocholine	phosphocholine	NNP
cord-280878-1kt51viz	241	10	(	(	-LRB-
cord-280878-1kt51viz	241	11	DPC	DPC	NNP
cord-280878-1kt51viz	241	12	)	)	-RRB-
cord-280878-1kt51viz	241	13	micelles	micelle	NNS
cord-280878-1kt51viz	241	14	was	be	VBD
cord-280878-1kt51viz	241	15	not	not	RB
cord-280878-1kt51viz	241	16	determined	determine	VBN
cord-280878-1kt51viz	241	17	,	,	,
cord-280878-1kt51viz	241	18	this	this	DT
cord-280878-1kt51viz	241	19	was	be	VBD
cord-280878-1kt51viz	241	20	combined	combine	VBN
cord-280878-1kt51viz	241	21	with	with	IN
cord-280878-1kt51viz	241	22	data	datum	NNS
cord-280878-1kt51viz	241	23	from	from	IN
cord-280878-1kt51viz	241	24	negative	negative	JJ
cord-280878-1kt51viz	241	25	stain	stain	NN
cord-280878-1kt51viz	241	26	electron	electron	NN
cord-280878-1kt51viz	241	27	microscopy	microscopy	NN
cord-280878-1kt51viz	241	28	(	(	-LRB-
cord-280878-1kt51viz	241	29	EM	EM	NNP
cord-280878-1kt51viz	241	30	)	)	-RRB-
cord-280878-1kt51viz	241	31	,	,	,
cord-280878-1kt51viz	241	32	which	which	WDT
cord-280878-1kt51viz	241	33	showed	show	VBD
cord-280878-1kt51viz	241	34	hexameric	hexameric	JJ
cord-280878-1kt51viz	241	35	,	,	,
cord-280878-1kt51viz	241	36	flower	flower	NN
cord-280878-1kt51viz	241	37	-	-	HYPH
cord-280878-1kt51viz	241	38	shaped	shape	VBN
cord-280878-1kt51viz	241	39	particles	particle	NNS
cord-280878-1kt51viz	241	40	.	.	.
cord-280878-1kt51viz	242	1	The	the	DT
cord-280878-1kt51viz	242	2	latter	latter	JJ
cord-280878-1kt51viz	242	3	were	be	VBD
cord-280878-1kt51viz	242	4	similar	similar	JJ
cord-280878-1kt51viz	242	5	to	to	IN
cord-280878-1kt51viz	242	6	those	those	DT
cord-280878-1kt51viz	242	7	p7	p7	NNP
cord-280878-1kt51viz	242	8	hexamers	hexamer	NNS
cord-280878-1kt51viz	242	9	(	(	-LRB-
cord-280878-1kt51viz	242	10	of	of	IN
cord-280878-1kt51viz	242	11	GT2aJFH-1	GT2aJFH-1	NNPS
cord-280878-1kt51viz	242	12	)	)	-RRB-
cord-280878-1kt51viz	242	13	observed	observe	VBD
cord-280878-1kt51viz	242	14	in	in	IN
cord-280878-1kt51viz	242	15	EM	EM	NNP
cord-280878-1kt51viz	242	16	in	in	IN
cord-280878-1kt51viz	242	17	the	the	DT
cord-280878-1kt51viz	242	18	presence	presence	NN
cord-280878-1kt51viz	242	19	of	of	IN
cord-280878-1kt51viz	242	20	DHPC	DHPC	NNP
cord-280878-1kt51viz	242	21	micelles	micelle	NNS
cord-280878-1kt51viz	242	22	used	use	VBN
cord-280878-1kt51viz	242	23	earlier	early	RBR
cord-280878-1kt51viz	242	24	for	for	IN
cord-280878-1kt51viz	242	25	single	single	JJ
cord-280878-1kt51viz	242	26	-	-	HYPH
cord-280878-1kt51viz	242	27	particle	particle	NN
cord-280878-1kt51viz	242	28	reconstruction	reconstruction	NN
cord-280878-1kt51viz	243	1	(	(	-LRB-
cord-280878-1kt51viz	243	2	Luik	Luik	NNP
cord-280878-1kt51viz	243	3	et	et	FW
cord-280878-1kt51viz	243	4	al	al	NNP
cord-280878-1kt51viz	243	5	.	.	NNP
cord-280878-1kt51viz	243	6	,	,	,
cord-280878-1kt51viz	243	7	2009	2009	CD
cord-280878-1kt51viz	243	8	)	)	-RRB-
cord-280878-1kt51viz	243	9	.	.	.
cord-280878-1kt51viz	244	1	The	the	DT
cord-280878-1kt51viz	244	2	NMR	NMR	NNP
cord-280878-1kt51viz	244	3	-	-	HYPH
cord-280878-1kt51viz	244	4	based	base	VBN
cord-280878-1kt51viz	244	5	model	model	NN
cord-280878-1kt51viz	244	6	showed	show	VBD
cord-280878-1kt51viz	244	7	that	that	IN
cord-280878-1kt51viz	244	8	the	the	DT
cord-280878-1kt51viz	244	9	C	C	NNP
cord-280878-1kt51viz	244	10	-	-	HYPH
cord-280878-1kt51viz	244	11	terminal	terminal	NN
cord-280878-1kt51viz	244	12	helix	helix	NN
cord-280878-1kt51viz	244	13	,	,	,
cord-280878-1kt51viz	244	14	p7(27	p7(27	NNP
cord-280878-1kt51viz	244	15	-	-	HYPH
cord-280878-1kt51viz	244	16	63	63	CD
cord-280878-1kt51viz	244	17	)	)	-RRB-
cord-280878-1kt51viz	244	18	,	,	,
cord-280878-1kt51viz	244	19	is	be	VBZ
cord-280878-1kt51viz	244	20	not	not	RB
cord-280878-1kt51viz	244	21	the	the	DT
cord-280878-1kt51viz	244	22	pore	pore	NN
cord-280878-1kt51viz	244	23	-	-	HYPH
cord-280878-1kt51viz	244	24	lining	lining	NN
cord-280878-1kt51viz	244	25	sequence	sequence	NN
cord-280878-1kt51viz	244	26	but	but	CC
cord-280878-1kt51viz	244	27	instead	instead	RB
cord-280878-1kt51viz	244	28	forms	form	VBZ
cord-280878-1kt51viz	244	29	a	a	DT
cord-280878-1kt51viz	244	30	"	"	``
cord-280878-1kt51viz	244	31	lipid	lipid	NN
cord-280878-1kt51viz	244	32	facing	face	VBG
cord-280878-1kt51viz	244	33	"	"	''
cord-280878-1kt51viz	244	34	part	part	NN
cord-280878-1kt51viz	244	35	of	of	IN
cord-280878-1kt51viz	244	36	the	the	DT
cord-280878-1kt51viz	244	37	molecule	molecule	NN
cord-280878-1kt51viz	244	38	,	,	,
cord-280878-1kt51viz	244	39	whereas	whereas	IN
cord-280878-1kt51viz	244	40	the	the	DT
cord-280878-1kt51viz	244	41	N	n	CD
cord-280878-1kt51viz	244	42	-	-	HYPH
cord-280878-1kt51viz	244	43	terminal	terminal	JJ
cord-280878-1kt51viz	244	44	half	half	NN
cord-280878-1kt51viz	244	45	would	would	MD
cord-280878-1kt51viz	244	46	orient	orient	VB
cord-280878-1kt51viz	244	47	lining	line	VBG
cord-280878-1kt51viz	244	48	the	the	DT
cord-280878-1kt51viz	244	49	lumen	lumen	NN
cord-280878-1kt51viz	244	50	(	(	-LRB-
cord-280878-1kt51viz	244	51	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	244	52	et	et	NNP
cord-280878-1kt51viz	244	53	al	al	NNP
cord-280878-1kt51viz	244	54	.	.	NNP
cord-280878-1kt51viz	244	55	,	,	,
cord-280878-1kt51viz	244	56	2013	2013	CD
cord-280878-1kt51viz	244	57	)	)	-RRB-
cord-280878-1kt51viz	244	58	.	.	.
cord-280878-1kt51viz	245	1	This	this	DT
cord-280878-1kt51viz	245	2	is	be	VBZ
cord-280878-1kt51viz	245	3	in	in	IN
cord-280878-1kt51viz	245	4	agreement	agreement	NN
cord-280878-1kt51viz	245	5	with	with	IN
cord-280878-1kt51viz	245	6	previous	previous	JJ
cord-280878-1kt51viz	245	7	models	model	NNS
cord-280878-1kt51viz	245	8	based	base	VBN
cord-280878-1kt51viz	245	9	on	on	IN
cord-280878-1kt51viz	245	10	the	the	DT
cord-280878-1kt51viz	245	11	partial	partial	JJ
cord-280878-1kt51viz	245	12	inhibition	inhibition	NN
cord-280878-1kt51viz	245	13	of	of	IN
cord-280878-1kt51viz	245	14	p7	p7	NN
cord-280878-1kt51viz	245	15	channel	channel	NN
cord-280878-1kt51viz	245	16	activity	activity	NN
cord-280878-1kt51viz	245	17	by	by	IN
cord-280878-1kt51viz	245	18	Cu	Cu	NNP
cord-280878-1kt51viz	245	19	2	2	CD
cord-280878-1kt51viz	245	20	+	+	CC
cord-280878-1kt51viz	245	21	,	,	,
cord-280878-1kt51viz	245	22	but	but	CC
cord-280878-1kt51viz	245	23	not	not	RB
cord-280878-1kt51viz	245	24	by	by	IN
cord-280878-1kt51viz	245	25	Mg	Mg	NNP
cord-280878-1kt51viz	245	26	2	2	CD
cord-280878-1kt51viz	246	1	+	+	UH
cord-280878-1kt51viz	246	2	,	,	,
cord-280878-1kt51viz	246	3	which	which	WDT
cord-280878-1kt51viz	246	4	suggested	suggest	VBD
cord-280878-1kt51viz	246	5	exposure	exposure	NN
cord-280878-1kt51viz	246	6	to	to	IN
cord-280878-1kt51viz	246	7	a	a	DT
cord-280878-1kt51viz	246	8	His	-PRON-	PRP$
cord-280878-1kt51viz	246	9	residue	residue	NN
cord-280878-1kt51viz	246	10	located	locate	VBN
cord-280878-1kt51viz	246	11	in	in	IN
cord-280878-1kt51viz	246	12	the	the	DT
cord-280878-1kt51viz	246	13	N	n	CD
cord-280878-1kt51viz	246	14	-	-	HYPH
cord-280878-1kt51viz	246	15	terminal	terminal	NN
cord-280878-1kt51viz	246	16	half	half	NN
cord-280878-1kt51viz	246	17	to	to	IN
cord-280878-1kt51viz	246	18	the	the	DT
cord-280878-1kt51viz	246	19	lumen	lumen	NN
cord-280878-1kt51viz	246	20	of	of	IN
cord-280878-1kt51viz	246	21	the	the	DT
cord-280878-1kt51viz	246	22	channel	channel	NN
cord-280878-1kt51viz	246	23	.	.	.
cord-280878-1kt51viz	247	1	Although	although	IN
cord-280878-1kt51viz	247	2	this	this	DT
cord-280878-1kt51viz	247	3	interpretation	interpretation	NN
cord-280878-1kt51viz	247	4	may	may	MD
cord-280878-1kt51viz	247	5	be	be	VB
cord-280878-1kt51viz	247	6	correct	correct	JJ
cord-280878-1kt51viz	247	7	,	,	,
cord-280878-1kt51viz	247	8	it	-PRON-	PRP
cord-280878-1kt51viz	247	9	is	be	VBZ
cord-280878-1kt51viz	247	10	unfortunate	unfortunate	JJ
cord-280878-1kt51viz	247	11	that	that	IN
cord-280878-1kt51viz	247	12	synthetic	synthetic	JJ
cord-280878-1kt51viz	247	13	peptides	peptide	NNS
cord-280878-1kt51viz	247	14	corresponding	correspond	VBG
cord-280878-1kt51viz	247	15	to	to	IN
cord-280878-1kt51viz	247	16	the	the	DT
cord-280878-1kt51viz	247	17	N	N	NNP
cord-280878-1kt51viz	247	18	-	-	HYPH
cord-280878-1kt51viz	247	19	terminal	terminal	JJ
cord-280878-1kt51viz	247	20	half	half	PDT
cord-280878-1kt51viz	247	21	"	"	``
cord-280878-1kt51viz	247	22	TM1	tm1	NN
cord-280878-1kt51viz	247	23	,	,	,
cord-280878-1kt51viz	247	24	"	"	''
cord-280878-1kt51viz	247	25	eg	eg	XX
cord-280878-1kt51viz	247	26	,	,	,
cord-280878-1kt51viz	247	27	p7(1	p7(1	NNP
cord-280878-1kt51viz	247	28	-	-	HYPH
cord-280878-1kt51viz	247	29	34	34	CD
cord-280878-1kt51viz	247	30	)	)	-RRB-
cord-280878-1kt51viz	247	31	or	or	CC
cord-280878-1kt51viz	247	32	the	the	DT
cord-280878-1kt51viz	247	33	C	C	NNP
cord-280878-1kt51viz	247	34	-	-	HYPH
cord-280878-1kt51viz	247	35	terminal	terminal	NN
cord-280878-1kt51viz	247	36	half	half	PDT
cord-280878-1kt51viz	247	37	"	"	``
cord-280878-1kt51viz	247	38	TM2	tm2	NN
cord-280878-1kt51viz	247	39	,	,	,
cord-280878-1kt51viz	247	40	"	"	''
cord-280878-1kt51viz	247	41	eg	eg	IN
cord-280878-1kt51viz	247	42	,	,	,
cord-280878-1kt51viz	247	43	p7(35	p7(35	NNP
cord-280878-1kt51viz	247	44	-	-	HYPH
cord-280878-1kt51viz	247	45	63	63	CD
cord-280878-1kt51viz	247	46	)	)	-RRB-
cord-280878-1kt51viz	247	47	aggregate	aggregate	VBP
cord-280878-1kt51viz	247	48	easily	easily	RB
cord-280878-1kt51viz	247	49	,	,	,
cord-280878-1kt51viz	247	50	such	such	JJ
cord-280878-1kt51viz	247	51	that	that	IN
cord-280878-1kt51viz	247	52	individual	individual	JJ
cord-280878-1kt51viz	247	53	channel	channel	NN
cord-280878-1kt51viz	247	54	activity	activity	NN
cord-280878-1kt51viz	247	55	of	of	IN
cord-280878-1kt51viz	247	56	these	these	DT
cord-280878-1kt51viz	247	57	peptides	peptide	NNS
cord-280878-1kt51viz	247	58	can	can	MD
cord-280878-1kt51viz	247	59	not	not	RB
cord-280878-1kt51viz	247	60	be	be	VB
cord-280878-1kt51viz	247	61	properly	properly	RB
cord-280878-1kt51viz	247	62	measured	measure	VBN
cord-280878-1kt51viz	248	1	(	(	-LRB-
cord-280878-1kt51viz	248	2	Montserret	Montserret	NNP
cord-280878-1kt51viz	248	3	et	et	NNP
cord-280878-1kt51viz	248	4	al	al	NNP
cord-280878-1kt51viz	248	5	.	.	NNP
cord-280878-1kt51viz	248	6	,	,	,
cord-280878-1kt51viz	248	7	2010	2010	CD
cord-280878-1kt51viz	248	8	)	)	-RRB-
cord-280878-1kt51viz	248	9	.	.	.
cord-280878-1kt51viz	249	1	In	in	IN
cord-280878-1kt51viz	249	2	fact	fact	NN
cord-280878-1kt51viz	249	3	,	,	,
cord-280878-1kt51viz	249	4	neither	neither	DT
cord-280878-1kt51viz	249	5	of	of	IN
cord-280878-1kt51viz	249	6	these	these	DT
cord-280878-1kt51viz	249	7	helices	helix	NNS
cord-280878-1kt51viz	249	8	separately	separately	RB
cord-280878-1kt51viz	249	9	forms	form	VBZ
cord-280878-1kt51viz	249	10	α	α	NN
cord-280878-1kt51viz	249	11	-	-	HYPH
cord-280878-1kt51viz	249	12	helical	helical	JJ
cord-280878-1kt51viz	249	13	structure	structure	NN
cord-280878-1kt51viz	249	14	in	in	IN
cord-280878-1kt51viz	249	15	micelles	micelle	NNS
cord-280878-1kt51viz	249	16	or	or	CC
cord-280878-1kt51viz	249	17	membranes	membrane	NNS
cord-280878-1kt51viz	249	18	,	,	,
cord-280878-1kt51viz	249	19	and	and	CC
cord-280878-1kt51viz	249	20	peptide	peptide	JJ
cord-280878-1kt51viz	249	21	p7(1	p7(1	NNP
cord-280878-1kt51viz	249	22	-	-	HYPH
cord-280878-1kt51viz	249	23	26	26	CD
cord-280878-1kt51viz	249	24	)	)	-RRB-
cord-280878-1kt51viz	249	25	was	be	VBD
cord-280878-1kt51viz	249	26	totally	totally	RB
cord-280878-1kt51viz	249	27	insoluble	insoluble	JJ
cord-280878-1kt51viz	249	28	in	in	IN
cord-280878-1kt51viz	249	29	TFE	TFE	NNP
cord-280878-1kt51viz	249	30	or	or	CC
cord-280878-1kt51viz	249	31	in	in	IN
cord-280878-1kt51viz	249	32	detergent	detergent	NN
cord-280878-1kt51viz	250	1	(	(	-LRB-
cord-280878-1kt51viz	250	2	Gan	Gan	NNP
cord-280878-1kt51viz	250	3	et	et	NNP
cord-280878-1kt51viz	250	4	al	al	NNP
cord-280878-1kt51viz	250	5	.	.	NNP
cord-280878-1kt51viz	250	6	,	,	,
cord-280878-1kt51viz	250	7	2014	2014	CD
cord-280878-1kt51viz	250	8	)	)	-RRB-
cord-280878-1kt51viz	250	9	,	,	,
cord-280878-1kt51viz	250	10	a	a	DT
cord-280878-1kt51viz	250	11	difficulty	difficulty	NN
cord-280878-1kt51viz	250	12	also	also	RB
cord-280878-1kt51viz	250	13	encountered	encounter	VBN
cord-280878-1kt51viz	250	14	for	for	IN
cord-280878-1kt51viz	250	15	the	the	DT
cord-280878-1kt51viz	250	16	N	n	CD
cord-280878-1kt51viz	250	17	-	-	HYPH
cord-280878-1kt51viz	250	18	terminal	terminal	NN
cord-280878-1kt51viz	250	19	fragment	fragment	NN
cord-280878-1kt51viz	250	20	of	of	IN
cord-280878-1kt51viz	250	21	p7(1	p7(1	NNP
cord-280878-1kt51viz	250	22	-	-	HYPH
cord-280878-1kt51viz	250	23	34	34	CD
cord-280878-1kt51viz	250	24	)	)	-RRB-
cord-280878-1kt51viz	251	1	(	(	-LRB-
cord-280878-1kt51viz	251	2	Montserret	Montserret	NNP
cord-280878-1kt51viz	251	3	et	et	NNP
cord-280878-1kt51viz	251	4	al	al	NNP
cord-280878-1kt51viz	251	5	.	.	NNP
cord-280878-1kt51viz	251	6	,	,	,
cord-280878-1kt51viz	251	7	2010	2010	CD
cord-280878-1kt51viz	251	8	)	)	-RRB-
cord-280878-1kt51viz	251	9	.	.	.
cord-280878-1kt51viz	252	1	In	in	IN
cord-280878-1kt51viz	252	2	contrast	contrast	NN
cord-280878-1kt51viz	252	3	,	,	,
cord-280878-1kt51viz	252	4	TM	TM	NNP
cord-280878-1kt51viz	252	5	domains	domain	NNS
cord-280878-1kt51viz	252	6	of	of	IN
cord-280878-1kt51viz	252	7	other	other	JJ
cord-280878-1kt51viz	252	8	viroporins	viroporin	NNS
cord-280878-1kt51viz	252	9	are	be	VBP
cord-280878-1kt51viz	252	10	completely	completely	RB
cord-280878-1kt51viz	252	11	α	α	NN
cord-280878-1kt51viz	252	12	-	-	HYPH
cord-280878-1kt51viz	252	13	helical	helical	JJ
cord-280878-1kt51viz	252	14	,	,	,
cord-280878-1kt51viz	252	15	eg	eg	XX
cord-280878-1kt51viz	252	16	,	,	,
cord-280878-1kt51viz	252	17	the	the	DT
cord-280878-1kt51viz	252	18	IAV	IAV	NNP
cord-280878-1kt51viz	252	19	M2	M2	NNP
cord-280878-1kt51viz	252	20	(	(	-LRB-
cord-280878-1kt51viz	252	21	Torres	Torres	NNP
cord-280878-1kt51viz	252	22	,	,	,
cord-280878-1kt51viz	252	23	Kukol	Kukol	NNP
cord-280878-1kt51viz	252	24	,	,	,
cord-280878-1kt51viz	252	25	&	&	CC
cord-280878-1kt51viz	252	26	Arkin	Arkin	NNP
cord-280878-1kt51viz	252	27	,	,	,
cord-280878-1kt51viz	252	28	2000	2000	CD
cord-280878-1kt51viz	252	29	)	)	-RRB-
cord-280878-1kt51viz	252	30	,	,	,
cord-280878-1kt51viz	252	31	severe	severe	JJ
cord-280878-1kt51viz	252	32	acute	acute	JJ
cord-280878-1kt51viz	252	33	respiratory	respiratory	JJ
cord-280878-1kt51viz	252	34	syndrome	syndrome	NN
cord-280878-1kt51viz	252	35	coronavirus	coronavirus	NN
cord-280878-1kt51viz	252	36	(	(	-LRB-
cord-280878-1kt51viz	252	37	SARS	SARS	NNP
cord-280878-1kt51viz	252	38	-	-	HYPH
cord-280878-1kt51viz	252	39	CoV	CoV	NNP
cord-280878-1kt51viz	252	40	)	)	-RRB-
cord-280878-1kt51viz	252	41	E	E	NNP
cord-280878-1kt51viz	252	42	,	,	,
cord-280878-1kt51viz	252	43	or	or	CC
cord-280878-1kt51viz	252	44	respiratory	respiratory	JJ
cord-280878-1kt51viz	252	45	syncytial	syncytial	JJ
cord-280878-1kt51viz	252	46	virus	virus	NN
cord-280878-1kt51viz	252	47	(	(	-LRB-
cord-280878-1kt51viz	252	48	RSV	RSV	NNP
cord-280878-1kt51viz	252	49	)	)	-RRB-
cord-280878-1kt51viz	252	50	SH	SH	NNP
cord-280878-1kt51viz	253	1	(	(	-LRB-
cord-280878-1kt51viz	253	2	Gan	Gan	NNP
cord-280878-1kt51viz	253	3	et	et	NNP
cord-280878-1kt51viz	253	4	al	al	NNP
cord-280878-1kt51viz	253	5	.	.	NNP
cord-280878-1kt51viz	253	6	,	,	,
cord-280878-1kt51viz	253	7	2012	2012	CD
cord-280878-1kt51viz	253	8	)	)	-RRB-
cord-280878-1kt51viz	253	9	produce	produce	VBP
cord-280878-1kt51viz	253	10	sharp	sharp	JJ
cord-280878-1kt51viz	253	11	amide	amide	NN
cord-280878-1kt51viz	254	1	I	-PRON-	PRP
cord-280878-1kt51viz	254	2	bands	band	NNS
cord-280878-1kt51viz	254	3	in	in	IN
cord-280878-1kt51viz	254	4	the	the	DT
cord-280878-1kt51viz	254	5	infrared	infrared	JJ
cord-280878-1kt51viz	254	6	spectrum	spectrum	NN
cord-280878-1kt51viz	254	7	consistent	consistent	JJ
cord-280878-1kt51viz	254	8	with	with	IN
cord-280878-1kt51viz	254	9	$	$	$
cord-280878-1kt51viz	254	10	100	100	CD
cord-280878-1kt51viz	254	11	%	%	NN
cord-280878-1kt51viz	254	12	α	α	NN
cord-280878-1kt51viz	254	13	-	-	HYPH
cord-280878-1kt51viz	254	14	helix	helix	NN
cord-280878-1kt51viz	254	15	.	.	.
cord-280878-1kt51viz	255	1	Nevertheless	nevertheless	RB
cord-280878-1kt51viz	255	2	,	,	,
cord-280878-1kt51viz	255	3	the	the	DT
cord-280878-1kt51viz	255	4	Amt	Amt	NNP
cord-280878-1kt51viz	255	5	binding	binding	NN
cord-280878-1kt51viz	255	6	site	site	NN
cord-280878-1kt51viz	255	7	in	in	IN
cord-280878-1kt51viz	255	8	the	the	DT
cord-280878-1kt51viz	255	9	p7	p7	NN
cord-280878-1kt51viz	255	10	channel	channel	NN
cord-280878-1kt51viz	255	11	was	be	VBD
cord-280878-1kt51viz	255	12	determined	determine	VBN
cord-280878-1kt51viz	255	13	by	by	IN
cord-280878-1kt51viz	255	14	identifying	identify	VBG
cord-280878-1kt51viz	255	15	Nuclear	Nuclear	NNP
cord-280878-1kt51viz	255	16	Overhauser	Overhauser	NNP
cord-280878-1kt51viz	255	17	Enhancements	enhancement	NNS
cord-280878-1kt51viz	255	18	(	(	-LRB-
cord-280878-1kt51viz	255	19	NOEs	no	NNS
cord-280878-1kt51viz	255	20	)	)	-RRB-
cord-280878-1kt51viz	255	21	between	between	IN
cord-280878-1kt51viz	255	22	the	the	DT
cord-280878-1kt51viz	255	23	protein	protein	NN
cord-280878-1kt51viz	255	24	backbone	backbone	NN
cord-280878-1kt51viz	255	25	amide	amide	NN
cord-280878-1kt51viz	255	26	protons	proton	NNS
cord-280878-1kt51viz	255	27	and	and	CC
cord-280878-1kt51viz	255	28	drug	drug	NN
cord-280878-1kt51viz	255	29	protons	proton	NNS
cord-280878-1kt51viz	256	1	(	(	-LRB-
cord-280878-1kt51viz	256	2	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	256	3	et	et	NNP
cord-280878-1kt51viz	256	4	al	al	NNP
cord-280878-1kt51viz	256	5	.	.	NNP
cord-280878-1kt51viz	256	6	,	,	,
cord-280878-1kt51viz	256	7	2013	2013	CD
cord-280878-1kt51viz	256	8	)	)	-RRB-
cord-280878-1kt51viz	257	1	(	(	-LRB-
cord-280878-1kt51viz	257	2	Fig	Fig	NNP
cord-280878-1kt51viz	257	3	.	.	NNP
cord-280878-1kt51viz	257	4	5	5	CD
cord-280878-1kt51viz	257	5	)	)	-RRB-
cord-280878-1kt51viz	257	6	.	.	.
cord-280878-1kt51viz	258	1	Although	although	IN
cord-280878-1kt51viz	258	2	the	the	DT
cord-280878-1kt51viz	258	3	full	full	JJ
cord-280878-1kt51viz	258	4	-	-	HYPH
cord-280878-1kt51viz	258	5	scale	scale	NN
cord-280878-1kt51viz	258	6	structure	structure	NN
cord-280878-1kt51viz	258	7	determination	determination	NN
cord-280878-1kt51viz	258	8	of	of	IN
cord-280878-1kt51viz	258	9	the	the	DT
cord-280878-1kt51viz	258	10	complex	complex	NN
cord-280878-1kt51viz	258	11	could	could	MD
cord-280878-1kt51viz	258	12	not	not	RB
cord-280878-1kt51viz	258	13	be	be	VB
cord-280878-1kt51viz	258	14	achieved	achieve	VBN
cord-280878-1kt51viz	258	15	,	,	,
cord-280878-1kt51viz	258	16	Amt	Amt	NNP
cord-280878-1kt51viz	258	17	(	(	-LRB-
cord-280878-1kt51viz	258	18	10	10	CD
cord-280878-1kt51viz	258	19	mM	mm	CD
cord-280878-1kt51viz	258	20	)	)	-RRB-
cord-280878-1kt51viz	258	21	showed	show	VBD
cord-280878-1kt51viz	258	22	NOE	NOE	NNP
cord-280878-1kt51viz	258	23	cross	cross	NN
cord-280878-1kt51viz	258	24	-	-	NNS
cord-280878-1kt51viz	258	25	peaks	peak	NNS
cord-280878-1kt51viz	258	26	between	between	IN
cord-280878-1kt51viz	258	27	the	the	DT
cord-280878-1kt51viz	258	28	adamantane	adamantane	NNP
cord-280878-1kt51viz	258	29	protons	proton	NNS
cord-280878-1kt51viz	258	30	and	and	CC
cord-280878-1kt51viz	258	31	the	the	DT
cord-280878-1kt51viz	258	32	amide	amide	NN
cord-280878-1kt51viz	258	33	protons	proton	NNS
cord-280878-1kt51viz	258	34	of	of	IN
cord-280878-1kt51viz	258	35	Val-26	Val-26	NNP
cord-280878-1kt51viz	258	36	,	,	,
cord-280878-1kt51viz	258	37	Leu-55	Leu-55	NNP
cord-280878-1kt51viz	258	38	,	,	,
cord-280878-1kt51viz	258	39	Leu-56	Leu-56	NNP
cord-280878-1kt51viz	258	40	,	,	,
cord-280878-1kt51viz	258	41	and	and	CC
cord-280878-1kt51viz	258	42	Arg-57	Arg-57	NNP
cord-280878-1kt51viz	258	43	,	,	,
cord-280878-1kt51viz	258	44	ie	ie	NNS
cord-280878-1kt51viz	258	45	,	,	,
cord-280878-1kt51viz	258	46	between	between	IN
cord-280878-1kt51viz	258	47	the	the	DT
cord-280878-1kt51viz	258	48	pore	pore	NN
cord-280878-1kt51viz	258	49	-	-	HYPH
cord-280878-1kt51viz	258	50	forming	form	VBG
cord-280878-1kt51viz	258	51	and	and	CC
cord-280878-1kt51viz	258	52	peripheral	peripheral	JJ
cord-280878-1kt51viz	258	53	helices	helix	NNS
cord-280878-1kt51viz	258	54	,	,	,
cord-280878-1kt51viz	258	55	suggesting	suggest	VBG
cord-280878-1kt51viz	258	56	a	a	DT
cord-280878-1kt51viz	258	57	pocket	pocket	NN
cord-280878-1kt51viz	258	58	formed	form	VBN
cord-280878-1kt51viz	258	59	by	by	IN
cord-280878-1kt51viz	258	60	Leu-52	Leu-52	NNP
cord-280878-1kt51viz	258	61	,	,	,
cord-280878-1kt51viz	258	62	Val-53	Val-53	NNP
cord-280878-1kt51viz	258	63	,	,	,
cord-280878-1kt51viz	258	64	and	and	CC
cord-280878-1kt51viz	258	65	Leu-56	Leu-56	NNP
cord-280878-1kt51viz	258	66	from	from	IN
cord-280878-1kt51viz	258	67	H3	H3	NNP
cord-280878-1kt51viz	258	68	,	,	,
cord-280878-1kt51viz	258	69	and	and	CC
cord-280878-1kt51viz	258	70	Phe-20	Phe-20	NNP
cord-280878-1kt51viz	258	71	,	,	,
cord-280878-1kt51viz	258	72	Val-25	Val-25	NNP
cord-280878-1kt51viz	258	73	,	,	,
cord-280878-1kt51viz	258	74	and	and	CC
cord-280878-1kt51viz	258	75	Val-26	Val-26	NNP
cord-280878-1kt51viz	258	76	from	from	IN
cord-280878-1kt51viz	258	77	H2	H2	NNP
cord-280878-1kt51viz	258	78	,	,	,
cord-280878-1kt51viz	258	79	with	with	IN
cord-280878-1kt51viz	258	80	the	the	DT
cord-280878-1kt51viz	258	81	polar	polar	JJ
cord-280878-1kt51viz	258	82	amino	amino	NNP
cord-280878-1kt51viz	258	83	group	group	NN
cord-280878-1kt51viz	258	84	of	of	IN
cord-280878-1kt51viz	258	85	Amt	Amt	NNP
cord-280878-1kt51viz	258	86	pointing	point	VBG
cord-280878-1kt51viz	258	87	to	to	IN
cord-280878-1kt51viz	258	88	the	the	DT
cord-280878-1kt51viz	258	89	channel	channel	NN
cord-280878-1kt51viz	258	90	lumen	lumen	NNP
cord-280878-1kt51viz	258	91	,	,	,
cord-280878-1kt51viz	258	92	with	with	IN
cord-280878-1kt51viz	258	93	similar	similar	JJ
cord-280878-1kt51viz	258	94	results	result	NNS
cord-280878-1kt51viz	258	95	also	also	RB
cord-280878-1kt51viz	258	96	obtained	obtain	VBN
cord-280878-1kt51viz	258	97	for	for	IN
cord-280878-1kt51viz	258	98	Rim	Rim	NNP
cord-280878-1kt51viz	258	99	.	.	.
cord-280878-1kt51viz	259	1	Amt	Amt	NNP
cord-280878-1kt51viz	259	2	and	and	CC
cord-280878-1kt51viz	259	3	Rim	Rim	NNP
cord-280878-1kt51viz	259	4	have	have	VBP
cord-280878-1kt51viz	259	5	also	also	RB
cord-280878-1kt51viz	259	6	been	be	VBN
cord-280878-1kt51viz	259	7	reported	report	VBN
cord-280878-1kt51viz	259	8	previously	previously	RB
cord-280878-1kt51viz	259	9	to	to	TO
cord-280878-1kt51viz	259	10	interact	interact	VB
cord-280878-1kt51viz	259	11	with	with	IN
cord-280878-1kt51viz	259	12	some	some	DT
cord-280878-1kt51viz	259	13	residues	residue	NNS
cord-280878-1kt51viz	259	14	in	in	IN
cord-280878-1kt51viz	259	15	the	the	DT
cord-280878-1kt51viz	259	16	N	n	CD
cord-280878-1kt51viz	259	17	-	-	HYPH
cord-280878-1kt51viz	259	18	terminal	terminal	NN
cord-280878-1kt51viz	259	19	half	half	NN
cord-280878-1kt51viz	259	20	(	(	-LRB-
cord-280878-1kt51viz	259	21	Cook	Cook	NNP
cord-280878-1kt51viz	259	22	&	&	CC
cord-280878-1kt51viz	259	23	Opella	Opella	NNP
cord-280878-1kt51viz	259	24	,	,	,
cord-280878-1kt51viz	259	25	2009	2009	CD
cord-280878-1kt51viz	259	26	;	;	.
cord-280878-1kt51viz	260	1	StGelais	StGelais	NNP
cord-280878-1kt51viz	260	2	et	et	NNP
cord-280878-1kt51viz	260	3	al	al	NNP
cord-280878-1kt51viz	260	4	.	.	NNP
cord-280878-1kt51viz	260	5	,	,	,
cord-280878-1kt51viz	260	6	2009	2009	CD
cord-280878-1kt51viz	260	7	)	)	-RRB-
cord-280878-1kt51viz	260	8	.	.	.
cord-280878-1kt51viz	261	1	Isothermal	Isothermal	NNP
cord-280878-1kt51viz	261	2	titration	titration	NN
cord-280878-1kt51viz	261	3	calorimetry	calorimetry	NN
cord-280878-1kt51viz	261	4	and	and	CC
cord-280878-1kt51viz	261	5	NMR	NMR	NNP
cord-280878-1kt51viz	261	6	chemical	chemical	NN
cord-280878-1kt51viz	261	7	shift	shift	NN
cord-280878-1kt51viz	261	8	perturbation	perturbation	NN
cord-280878-1kt51viz	261	9	analyses	analysis	NNS
cord-280878-1kt51viz	261	10	of	of	IN
cord-280878-1kt51viz	261	11	p7(GT5a)-Rim	p7(gt5a)-rim	JJ
cord-280878-1kt51viz	261	12	interaction	interaction	NN
cord-280878-1kt51viz	261	13	produced	produce	VBD
cord-280878-1kt51viz	261	14	a	a	DT
cord-280878-1kt51viz	261	15	binding	binding	JJ
cord-280878-1kt51viz	261	16	constant	constant	NN
cord-280878-1kt51viz	261	17	(	(	-LRB-
cord-280878-1kt51viz	261	18	Kd	Kd	NNP
cord-280878-1kt51viz	261	19	)	)	-RRB-
cord-280878-1kt51viz	261	20	from	from	IN
cord-280878-1kt51viz	261	21	50	50	CD
cord-280878-1kt51viz	261	22	to	to	TO
cord-280878-1kt51viz	261	23	100	100	CD
cord-280878-1kt51viz	261	24	μM	μm	NN
cord-280878-1kt51viz	261	25	at	at	IN
cord-280878-1kt51viz	261	26	3	3	CD
cord-280878-1kt51viz	261	27	mM	mm	CD
cord-280878-1kt51viz	261	28	detergent	detergent	NN
cord-280878-1kt51viz	261	29	concentration	concentration	NN
cord-280878-1kt51viz	261	30	.	.	.
cord-280878-1kt51viz	262	1	The	the	DT
cord-280878-1kt51viz	262	2	authors	author	NNS
cord-280878-1kt51viz	262	3	proposed	propose	VBD
cord-280878-1kt51viz	262	4	that	that	IN
cord-280878-1kt51viz	262	5	large	large	JJ
cord-280878-1kt51viz	262	6	differences	difference	NNS
cord-280878-1kt51viz	262	7	in	in	IN
cord-280878-1kt51viz	262	8	drug	drug	NN
cord-280878-1kt51viz	262	9	efficacies	efficacy	NNS
cord-280878-1kt51viz	262	10	observed	observe	VBN
cord-280878-1kt51viz	262	11	between	between	IN
cord-280878-1kt51viz	262	12	different	different	JJ
cord-280878-1kt51viz	262	13	HCV	HCV	NNP
cord-280878-1kt51viz	262	14	genotypes	genotype	NNS
cord-280878-1kt51viz	262	15	are	be	VBP
cord-280878-1kt51viz	262	16	probably	probably	RB
cord-280878-1kt51viz	262	17	due	due	JJ
cord-280878-1kt51viz	262	18	to	to	IN
cord-280878-1kt51viz	262	19	variations	variation	NNS
cord-280878-1kt51viz	262	20	in	in	IN
cord-280878-1kt51viz	262	21	the	the	DT
cord-280878-1kt51viz	262	22	hydrophobicity	hydrophobicity	NN
cord-280878-1kt51viz	262	23	of	of	IN
cord-280878-1kt51viz	262	24	the	the	DT
cord-280878-1kt51viz	262	25	binding	bind	VBG
cord-280878-1kt51viz	262	26	pocket	pocket	NN
cord-280878-1kt51viz	262	27	among	among	IN
cord-280878-1kt51viz	262	28	p7	p7	NN
cord-280878-1kt51viz	262	29	variants	variant	NNS
cord-280878-1kt51viz	262	30	,	,	,
cord-280878-1kt51viz	262	31	and	and	CC
cord-280878-1kt51viz	262	32	that	that	IN
cord-280878-1kt51viz	262	33	the	the	DT
cord-280878-1kt51viz	262	34	adamantane	adamantane	NNP
cord-280878-1kt51viz	262	35	derivatives	derivative	NNS
cord-280878-1kt51viz	262	36	inhibit	inhibit	VBP
cord-280878-1kt51viz	262	37	channel	channel	NN
cord-280878-1kt51viz	262	38	activity	activity	NN
cord-280878-1kt51viz	262	39	by	by	IN
cord-280878-1kt51viz	262	40	restricting	restrict	VBG
cord-280878-1kt51viz	262	41	the	the	DT
cord-280878-1kt51viz	262	42	structural	structural	JJ
cord-280878-1kt51viz	262	43	rearrangement	rearrangement	NN
cord-280878-1kt51viz	262	44	of	of	IN
cord-280878-1kt51viz	262	45	the	the	DT
cord-280878-1kt51viz	262	46	channel	channel	NN
cord-280878-1kt51viz	262	47	,	,	,
cord-280878-1kt51viz	262	48	ie	ie	NNP
cord-280878-1kt51viz	262	49	,	,	,
cord-280878-1kt51viz	262	50	an	an	DT
cord-280878-1kt51viz	262	51	allosteric	allosteric	JJ
cord-280878-1kt51viz	262	52	mechanism	mechanism	NN
cord-280878-1kt51viz	262	53	.	.	.
cord-280878-1kt51viz	263	1	Perhaps	perhaps	RB
cord-280878-1kt51viz	263	2	the	the	DT
cord-280878-1kt51viz	263	3	most	most	RBS
cord-280878-1kt51viz	263	4	efficient	efficient	JJ
cord-280878-1kt51viz	263	5	effect	effect	NN
cord-280878-1kt51viz	263	6	for	for	IN
cord-280878-1kt51viz	263	7	a	a	DT
cord-280878-1kt51viz	263	8	p7	p7	NN
cord-280878-1kt51viz	263	9	inhibitor	inhibitor	NN
cord-280878-1kt51viz	263	10	has	have	VBZ
cord-280878-1kt51viz	263	11	been	be	VBN
cord-280878-1kt51viz	263	12	reported	report	VBN
cord-280878-1kt51viz	263	13	for	for	IN
cord-280878-1kt51viz	263	14	BIT225	BIT225	NNP
cord-280878-1kt51viz	263	15	(	(	-LRB-
cord-280878-1kt51viz	263	16	N-[5-(1-methyl-1H	N-[5-(1-methyl-1H	:
cord-280878-1kt51viz	263	17	-	-	HYPH
cord-280878-1kt51viz	263	18	pyrazol-4-yl)-napthalene-2-carbonyl]guanidine	pyrazol-4-yl)-napthalene-2-carbonyl]guanidine	ADD
cord-280878-1kt51viz	263	19	)	)	-RRB-
cord-280878-1kt51viz	263	20	(	(	-LRB-
cord-280878-1kt51viz	263	21	Fig	Fig	NNP
cord-280878-1kt51viz	263	22	.	.	.
cord-280878-1kt51viz	263	23	4C	4c	CD
cord-280878-1kt51viz	263	24	)	)	-RRB-
cord-280878-1kt51viz	263	25	.	.	.
cord-280878-1kt51viz	264	1	This	this	DT
cord-280878-1kt51viz	264	2	amiloride	amiloride	NN
cord-280878-1kt51viz	264	3	was	be	VBD
cord-280878-1kt51viz	264	4	identified	identify	VBN
cord-280878-1kt51viz	264	5	in	in	IN
cord-280878-1kt51viz	264	6	a	a	DT
cord-280878-1kt51viz	264	7	bacterial	bacterial	JJ
cord-280878-1kt51viz	264	8	assay	assay	NN
cord-280878-1kt51viz	264	9	that	that	WDT
cord-280878-1kt51viz	264	10	involved	involve	VBD
cord-280878-1kt51viz	264	11	expression	expression	NN
cord-280878-1kt51viz	264	12	of	of	IN
cord-280878-1kt51viz	264	13	p7	p7	NN
cord-280878-1kt51viz	264	14	in	in	IN
cord-280878-1kt51viz	264	15	E.	E.	NNP
cord-280878-1kt51viz	264	16	coli	coli	NNS
cord-280878-1kt51viz	264	17	;	;	:
cord-280878-1kt51viz	264	18	only	only	RB
cord-280878-1kt51viz	264	19	in	in	IN
cord-280878-1kt51viz	264	20	presence	presence	NN
cord-280878-1kt51viz	264	21	of	of	IN
cord-280878-1kt51viz	264	22	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	264	23	the	the	DT
cord-280878-1kt51viz	264	24	normal	normal	JJ
cord-280878-1kt51viz	264	25	ionic	ionic	JJ
cord-280878-1kt51viz	264	26	gradients	gradient	NNS
cord-280878-1kt51viz	264	27	are	be	VBP
cord-280878-1kt51viz	264	28	maintained	maintain	VBN
cord-280878-1kt51viz	264	29	and	and	CC
cord-280878-1kt51viz	264	30	cells	cell	NNS
cord-280878-1kt51viz	264	31	are	be	VBP
cord-280878-1kt51viz	264	32	able	able	JJ
cord-280878-1kt51viz	264	33	to	to	TO
cord-280878-1kt51viz	264	34	grow	grow	VB
cord-280878-1kt51viz	264	35	despite	despite	IN
cord-280878-1kt51viz	264	36	the	the	DT
cord-280878-1kt51viz	264	37	presence	presence	NN
cord-280878-1kt51viz	264	38	of	of	IN
cord-280878-1kt51viz	264	39	p7	p7	NN
cord-280878-1kt51viz	264	40	.	.	.
cord-280878-1kt51viz	265	1	This	this	DT
cord-280878-1kt51viz	265	2	compound	compound	NN
cord-280878-1kt51viz	265	3	had	have	VBD
cord-280878-1kt51viz	265	4	antiviral	antiviral	JJ
cord-280878-1kt51viz	265	5	activity	activity	NN
cord-280878-1kt51viz	265	6	against	against	IN
cord-280878-1kt51viz	265	7	the	the	DT
cord-280878-1kt51viz	265	8	HCV	HCV	NNP
cord-280878-1kt51viz	265	9	model	model	NN
cord-280878-1kt51viz	265	10	pestivirus	pestivirus	NN
cord-280878-1kt51viz	265	11	bovine	bovine	JJ
cord-280878-1kt51viz	265	12	viral	viral	JJ
cord-280878-1kt51viz	265	13	diarrhea	diarrhea	NN
cord-280878-1kt51viz	265	14	virus	virus	NN
cord-280878-1kt51viz	265	15	(	(	-LRB-
cord-280878-1kt51viz	265	16	BVDV	BVDV	NNP
cord-280878-1kt51viz	265	17	)	)	-RRB-
cord-280878-1kt51viz	265	18	with	with	IN
cord-280878-1kt51viz	265	19	an	an	DT
cord-280878-1kt51viz	265	20	IC	IC	NNP
cord-280878-1kt51viz	265	21	50	50	CD
cord-280878-1kt51viz	265	22	of	of	IN
cord-280878-1kt51viz	265	23	314	314	CD
cord-280878-1kt51viz	265	24	nM.	nm.	NN
cord-280878-1kt51viz	266	1	The	the	DT
cord-280878-1kt51viz	266	2	addition	addition	NN
cord-280878-1kt51viz	266	3	of	of	IN
cord-280878-1kt51viz	266	4	100	100	CD
cord-280878-1kt51viz	266	5	μM	μm	NN
cord-280878-1kt51viz	266	6	of	of	IN
cord-280878-1kt51viz	266	7	BIT225	BIT225	NNP
cord-280878-1kt51viz	266	8	blocked	block	VBD
cord-280878-1kt51viz	266	9	ion	ion	NN
cord-280878-1kt51viz	266	10	channel	channel	NN
cord-280878-1kt51viz	266	11	activity	activity	NN
cord-280878-1kt51viz	266	12	of	of	IN
cord-280878-1kt51viz	266	13	synthetic	synthetic	JJ
cord-280878-1kt51viz	266	14	HCV	HCV	NNP
cord-280878-1kt51viz	266	15	p7	p7	NN
cord-280878-1kt51viz	266	16	protein	protein	NN
cord-280878-1kt51viz	266	17	of	of	IN
cord-280878-1kt51viz	266	18	GT1a	GT1a	NNP
cord-280878-1kt51viz	266	19	H77	H77	NNP
cord-280878-1kt51viz	266	20	,	,	,
cord-280878-1kt51viz	266	21	although	although	IN
cord-280878-1kt51viz	266	22	no	no	DT
cord-280878-1kt51viz	266	23	data	data	NN
cord-280878-1kt51viz	266	24	was	be	VBD
cord-280878-1kt51viz	266	25	reported	report	VBN
cord-280878-1kt51viz	266	26	in	in	IN
cord-280878-1kt51viz	266	27	the	the	DT
cord-280878-1kt51viz	266	28	context	context	NN
cord-280878-1kt51viz	266	29	of	of	IN
cord-280878-1kt51viz	266	30	HCV	HCV	NNP
cord-280878-1kt51viz	266	31	infection	infection	NN
cord-280878-1kt51viz	266	32	.	.	.
cord-280878-1kt51viz	267	1	While	while	IN
cord-280878-1kt51viz	267	2	some	some	DT
cord-280878-1kt51viz	267	3	docking	docking	NN
cord-280878-1kt51viz	267	4	efforts	effort	NNS
cord-280878-1kt51viz	267	5	have	have	VBP
cord-280878-1kt51viz	267	6	been	be	VBN
cord-280878-1kt51viz	267	7	performed	perform	VBN
cord-280878-1kt51viz	267	8	(	(	-LRB-
cord-280878-1kt51viz	267	9	Bichmann	Bichmann	NNP
cord-280878-1kt51viz	267	10	,	,	,
cord-280878-1kt51viz	267	11	Wang	Wang	NNP
cord-280878-1kt51viz	267	12	,	,	,
cord-280878-1kt51viz	267	13	&	&	CC
cord-280878-1kt51viz	267	14	Fischer	Fischer	NNP
cord-280878-1kt51viz	267	15	,	,	,
cord-280878-1kt51viz	267	16	2014	2014	CD
cord-280878-1kt51viz	267	17	)	)	-RRB-
cord-280878-1kt51viz	267	18	,	,	,
cord-280878-1kt51viz	267	19	direct	direct	JJ
cord-280878-1kt51viz	267	20	interaction	interaction	NN
cord-280878-1kt51viz	267	21	of	of	IN
cord-280878-1kt51viz	267	22	BIT225	BIT225	NNP
cord-280878-1kt51viz	267	23	with	with	IN
cord-280878-1kt51viz	267	24	p7	p7	NNP
cord-280878-1kt51viz	267	25	has	have	VBZ
cord-280878-1kt51viz	267	26	not	not	RB
cord-280878-1kt51viz	267	27	been	be	VBN
cord-280878-1kt51viz	267	28	proven	prove	VBN
cord-280878-1kt51viz	267	29	using	use	VBG
cord-280878-1kt51viz	267	30	biophysical	biophysical	JJ
cord-280878-1kt51viz	267	31	or	or	CC
cord-280878-1kt51viz	267	32	structural	structural	JJ
cord-280878-1kt51viz	267	33	assays	assay	NNS
cord-280878-1kt51viz	267	34	,	,	,
cord-280878-1kt51viz	267	35	and	and	CC
cord-280878-1kt51viz	267	36	therefore	therefore	RB
cord-280878-1kt51viz	267	37	rational	rational	JJ
cord-280878-1kt51viz	267	38	optimization	optimization	NN
cord-280878-1kt51viz	267	39	of	of	IN
cord-280878-1kt51viz	267	40	the	the	DT
cord-280878-1kt51viz	267	41	compound	compound	NN
cord-280878-1kt51viz	267	42	is	be	VBZ
cord-280878-1kt51viz	267	43	still	still	RB
cord-280878-1kt51viz	267	44	not	not	RB
cord-280878-1kt51viz	267	45	possible	possible	JJ
cord-280878-1kt51viz	267	46	.	.	.
cord-280878-1kt51viz	268	1	In	in	IN
cord-280878-1kt51viz	268	2	addition	addition	NN
cord-280878-1kt51viz	268	3	to	to	IN
cord-280878-1kt51viz	268	4	HCV	HCV	NNP
cord-280878-1kt51viz	268	5	p7	p7	NNP
cord-280878-1kt51viz	268	6	,	,	,
cord-280878-1kt51viz	268	7	the	the	DT
cord-280878-1kt51viz	268	8	human	human	JJ
cord-280878-1kt51viz	268	9	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	268	10	virus	virus	NN
cord-280878-1kt51viz	268	11	(	(	-LRB-
cord-280878-1kt51viz	268	12	HIV	HIV	NNP
cord-280878-1kt51viz	268	13	)	)	-RRB-
cord-280878-1kt51viz	268	14	viroporin	viroporin	NNP
cord-280878-1kt51viz	268	15	Vpu	Vpu	NNP
cord-280878-1kt51viz	268	16	is	be	VBZ
cord-280878-1kt51viz	268	17	also	also	RB
cord-280878-1kt51viz	268	18	targeted	target	VBN
cord-280878-1kt51viz	268	19	;	;	:
cord-280878-1kt51viz	268	20	BIT225	BIT225	NNP
cord-280878-1kt51viz	268	21	was	be	VBD
cord-280878-1kt51viz	268	22	tested	test	VBN
cord-280878-1kt51viz	268	23	against	against	IN
cord-280878-1kt51viz	268	24	the	the	DT
cord-280878-1kt51viz	268	25	Vpu	Vpu	NNP
cord-280878-1kt51viz	268	26	TM	TM	NNP
cord-280878-1kt51viz	268	27	domain	domain	NN
cord-280878-1kt51viz	268	28	using	use	VBG
cord-280878-1kt51viz	268	29	a	a	DT
cord-280878-1kt51viz	268	30	black	black	JJ
cord-280878-1kt51viz	268	31	lipid	lipid	NN
cord-280878-1kt51viz	268	32	membrane	membrane	NN
cord-280878-1kt51viz	268	33	(	(	-LRB-
cord-280878-1kt51viz	268	34	BLM	BLM	NNP
cord-280878-1kt51viz	268	35	)	)	-RRB-
cord-280878-1kt51viz	268	36	system	system	NN
cord-280878-1kt51viz	268	37	,	,	,
cord-280878-1kt51viz	268	38	where	where	WRB
cord-280878-1kt51viz	268	39	the	the	DT
cord-280878-1kt51viz	268	40	target	target	NN
cord-280878-1kt51viz	268	41	was	be	VBD
cord-280878-1kt51viz	268	42	exposed	expose	VBN
cord-280878-1kt51viz	268	43	to	to	IN
cord-280878-1kt51viz	268	44	40	40	CD
cord-280878-1kt51viz	268	45	μM	μm	CD
cord-280878-1kt51viz	268	46	of	of	IN
cord-280878-1kt51viz	268	47	the	the	DT
cord-280878-1kt51viz	268	48	drug	drug	NN
cord-280878-1kt51viz	268	49	(	(	-LRB-
cord-280878-1kt51viz	268	50	Khoury	Khoury	NNP
cord-280878-1kt51viz	268	51	,	,	,
cord-280878-1kt51viz	268	52	Ewart	Ewart	NNP
cord-280878-1kt51viz	268	53	,	,	,
cord-280878-1kt51viz	268	54	Luscombe	Luscombe	NNP
cord-280878-1kt51viz	268	55	,	,	,
cord-280878-1kt51viz	268	56	Miller	Miller	NNP
cord-280878-1kt51viz	268	57	,	,	,
cord-280878-1kt51viz	268	58	&	&	CC
cord-280878-1kt51viz	268	59	Wilkinson	Wilkinson	NNP
cord-280878-1kt51viz	268	60	,	,	,
cord-280878-1kt51viz	268	61	2010	2010	CD
cord-280878-1kt51viz	268	62	)	)	-RRB-
cord-280878-1kt51viz	268	63	.	.	.
cord-280878-1kt51viz	269	1	Although	although	IN
cord-280878-1kt51viz	269	2	direct	direct	JJ
cord-280878-1kt51viz	269	3	interaction	interaction	NN
cord-280878-1kt51viz	269	4	with	with	IN
cord-280878-1kt51viz	269	5	Vpu	Vpu	NNP
cord-280878-1kt51viz	269	6	was	be	VBD
cord-280878-1kt51viz	269	7	not	not	RB
cord-280878-1kt51viz	269	8	observed	observe	VBN
cord-280878-1kt51viz	269	9	,	,	,
cord-280878-1kt51viz	269	10	this	this	DT
cord-280878-1kt51viz	269	11	was	be	VBD
cord-280878-1kt51viz	269	12	assumed	assume	VBN
cord-280878-1kt51viz	269	13	since	since	IN
cord-280878-1kt51viz	269	14	the	the	DT
cord-280878-1kt51viz	269	15	drug	drug	NN
cord-280878-1kt51viz	269	16	was	be	VBD
cord-280878-1kt51viz	269	17	not	not	RB
cord-280878-1kt51viz	269	18	active	active	JJ
cord-280878-1kt51viz	269	19	against	against	IN
cord-280878-1kt51viz	269	20	HIV-2	HIV-2	NNP
cord-280878-1kt51viz	269	21	,	,	,
cord-280878-1kt51viz	269	22	which	which	WDT
cord-280878-1kt51viz	269	23	has	have	VBZ
cord-280878-1kt51viz	269	24	no	no	DT
cord-280878-1kt51viz	269	25	Vpu	Vpu	NNP
cord-280878-1kt51viz	269	26	gene	gene	NN
cord-280878-1kt51viz	269	27	.	.	.
cord-280878-1kt51viz	270	1	One	one	CD
cord-280878-1kt51viz	270	2	early	early	JJ
cord-280878-1kt51viz	270	3	clinical	clinical	JJ
cord-280878-1kt51viz	270	4	trial	trial	NN
cord-280878-1kt51viz	270	5	(	(	-LRB-
cord-280878-1kt51viz	270	6	phase	phase	NN
cord-280878-1kt51viz	270	7	Ib	Ib	NNP
cord-280878-1kt51viz	270	8	/	/	SYM
cord-280878-1kt51viz	270	9	IIa	IIa	NNP
cord-280878-1kt51viz	270	10	)	)	-RRB-
cord-280878-1kt51viz	270	11	involving	involve	VBG
cord-280878-1kt51viz	270	12	the	the	DT
cord-280878-1kt51viz	270	13	treatment	treatment	NN
cord-280878-1kt51viz	270	14	of	of	IN
cord-280878-1kt51viz	270	15	24	24	CD
cord-280878-1kt51viz	270	16	naïve	naïve	JJ
cord-280878-1kt51viz	270	17	GT1	GT1	NNP
cord-280878-1kt51viz	270	18	HCV	HCV	NNP
cord-280878-1kt51viz	270	19	patients	patient	NNS
cord-280878-1kt51viz	270	20	indicated	indicate	VBD
cord-280878-1kt51viz	270	21	a	a	DT
cord-280878-1kt51viz	270	22	significant	significant	JJ
cord-280878-1kt51viz	270	23	reduction	reduction	NN
cord-280878-1kt51viz	270	24	of	of	IN
cord-280878-1kt51viz	270	25	viral	viral	JJ
cord-280878-1kt51viz	270	26	load	load	NN
cord-280878-1kt51viz	270	27	after	after	IN
cord-280878-1kt51viz	270	28	12	12	CD
cord-280878-1kt51viz	270	29	weeks	week	NNS
cord-280878-1kt51viz	270	30	treatment	treatment	NN
cord-280878-1kt51viz	270	31	with	with	IN
cord-280878-1kt51viz	270	32	BIT225	BIT225	NNP
cord-280878-1kt51viz	270	33	in	in	IN
cord-280878-1kt51viz	270	34	combination	combination	NN
cord-280878-1kt51viz	270	35	with	with	IN
cord-280878-1kt51viz	270	36	IFNα	IFNα	NNP
cord-280878-1kt51viz	270	37	/	/	SYM
cord-280878-1kt51viz	270	38	ribavirin	ribavirin	NNP
cord-280878-1kt51viz	271	1	(	(	-LRB-
cord-280878-1kt51viz	271	2	www.biotron.com.au	www.biotron.com.au	JJ
cord-280878-1kt51viz	271	3	:	:	:
cord-280878-1kt51viz	271	4	biotron	biotron	NNP
cord-280878-1kt51viz	271	5	2011	2011	CD
cord-280878-1kt51viz	271	6	)	)	-RRB-
cord-280878-1kt51viz	271	7	.	.	.
cord-280878-1kt51viz	272	1	Currently	currently	RB
cord-280878-1kt51viz	272	2	,	,	,
cord-280878-1kt51viz	272	3	a	a	DT
cord-280878-1kt51viz	272	4	phase	phase	NN
cord-280878-1kt51viz	272	5	2a/2	2a/2	CD
cord-280878-1kt51viz	272	6	clinical	clinical	JJ
cord-280878-1kt51viz	272	7	trial	trial	NN
cord-280878-1kt51viz	272	8	is	be	VBZ
cord-280878-1kt51viz	272	9	in	in	IN
cord-280878-1kt51viz	272	10	progress	progress	NN
cord-280878-1kt51viz	272	11	and	and	CC
cord-280878-1kt51viz	272	12	the	the	DT
cord-280878-1kt51viz	272	13	first	first	JJ
cord-280878-1kt51viz	272	14	results	result	NNS
cord-280878-1kt51viz	272	15	indicate	indicate	VBP
cord-280878-1kt51viz	272	16	activity	activity	NN
cord-280878-1kt51viz	272	17	against	against	IN
cord-280878-1kt51viz	272	18	several	several	JJ
cord-280878-1kt51viz	272	19	HCV	HCV	NNP
cord-280878-1kt51viz	272	20	genotypes	genotype	NNS
cord-280878-1kt51viz	272	21	,	,	,
cord-280878-1kt51viz	272	22	including	include	VBG
cord-280878-1kt51viz	272	23	the	the	DT
cord-280878-1kt51viz	272	24	difficult	difficult	JJ
cord-280878-1kt51viz	272	25	-	-	HYPH
cord-280878-1kt51viz	272	26	to	to	TO
cord-280878-1kt51viz	272	27	-	-	HYPH
cord-280878-1kt51viz	272	28	treat	treat	VB
cord-280878-1kt51viz	272	29	GT3a	GT3a	NNP
cord-280878-1kt51viz	272	30	and	and	CC
cord-280878-1kt51viz	272	31	GT1a	GT1a	NNP
cord-280878-1kt51viz	272	32	(	(	-LRB-
cord-280878-1kt51viz	272	33	www.biotron.com	www.biotron.com	ADD
cord-280878-1kt51viz	272	34	.	.	.
cord-280878-1kt51viz	273	1	au	au	NNP
cord-280878-1kt51viz	273	2	;	;	:
cord-280878-1kt51viz	273	3	May	May	NNP
cord-280878-1kt51viz	273	4	29	29	CD
cord-280878-1kt51viz	273	5	,	,	,
cord-280878-1kt51viz	273	6	2015	2015	CD
cord-280878-1kt51viz	273	7	)	)	-RRB-
cord-280878-1kt51viz	273	8	.	.	.
cord-280878-1kt51viz	274	1	Since	since	IN
cord-280878-1kt51viz	274	2	it	-PRON-	PRP
cord-280878-1kt51viz	274	3	is	be	VBZ
cord-280878-1kt51viz	274	4	also	also	RB
cord-280878-1kt51viz	274	5	active	active	JJ
cord-280878-1kt51viz	274	6	against	against	IN
cord-280878-1kt51viz	274	7	the	the	DT
cord-280878-1kt51viz	274	8	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	274	9	Vpu	Vpu	NNP
cord-280878-1kt51viz	274	10	,	,	,
cord-280878-1kt51viz	274	11	BIT225	BIT225	NNP
cord-280878-1kt51viz	274	12	might	may	MD
cord-280878-1kt51viz	274	13	be	be	VB
cord-280878-1kt51viz	274	14	suitable	suitable	JJ
cord-280878-1kt51viz	274	15	for	for	IN
cord-280878-1kt51viz	274	16	treatment	treatment	NN
cord-280878-1kt51viz	274	17	of	of	IN
cord-280878-1kt51viz	274	18	HCV	HCV	NNP
cord-280878-1kt51viz	274	19	/	/	SYM
cord-280878-1kt51viz	274	20	HIV	HIV	NNP
cord-280878-1kt51viz	274	21	coinfected	coinfecte	VBD
cord-280878-1kt51viz	274	22	patients	patient	NNS
cord-280878-1kt51viz	274	23	.	.	.
cord-280878-1kt51viz	275	1	In	in	IN
cord-280878-1kt51viz	275	2	a	a	DT
cord-280878-1kt51viz	275	3	Jul.	July	NNP
cord-280878-1kt51viz	275	4	2015	2015	CD
cord-280878-1kt51viz	275	5	update	update	NN
cord-280878-1kt51viz	275	6	of	of	IN
cord-280878-1kt51viz	275	7	a	a	DT
cord-280878-1kt51viz	275	8	3-month	3-month	CD
cord-280878-1kt51viz	275	9	dosing	dosing	NN
cord-280878-1kt51viz	275	10	trial	trial	NN
cord-280878-1kt51viz	275	11	with	with	IN
cord-280878-1kt51viz	275	12	BIT225	BIT225	NNP
cord-280878-1kt51viz	275	13	,	,	,
cord-280878-1kt51viz	275	14	there	there	EX
cord-280878-1kt51viz	275	15	was	be	VBD
cord-280878-1kt51viz	275	16	a	a	DT
cord-280878-1kt51viz	275	17	recommendation	recommendation	NN
cord-280878-1kt51viz	275	18	that	that	IN
cord-280878-1kt51viz	275	19	future	future	JJ
cord-280878-1kt51viz	275	20	trials	trial	NNS
cord-280878-1kt51viz	275	21	would	would	MD
cord-280878-1kt51viz	275	22	focus	focus	VB
cord-280878-1kt51viz	275	23	on	on	IN
cord-280878-1kt51viz	275	24	patients	patient	NNS
cord-280878-1kt51viz	275	25	infected	infect	VBN
cord-280878-1kt51viz	275	26	with	with	IN
cord-280878-1kt51viz	275	27	HCV	HCV	NNP
cord-280878-1kt51viz	275	28	GT3	GT3	NNP
cord-280878-1kt51viz	275	29	and	and	CC
cord-280878-1kt51viz	275	30	to	to	TO
cord-280878-1kt51viz	275	31	further	further	RB
cord-280878-1kt51viz	275	32	study	study	VB
cord-280878-1kt51viz	275	33	BIT225	BIT225	NNP
cord-280878-1kt51viz	275	34	in	in	IN
cord-280878-1kt51viz	275	35	combination	combination	NN
cord-280878-1kt51viz	275	36	with	with	IN
cord-280878-1kt51viz	275	37	other	other	JJ
cord-280878-1kt51viz	275	38	direct	direct	JJ
cord-280878-1kt51viz	275	39	-	-	HYPH
cord-280878-1kt51viz	275	40	acting	act	VBG
cord-280878-1kt51viz	275	41	antiviral	antiviral	JJ
cord-280878-1kt51viz	275	42	drugs	drug	NNS
cord-280878-1kt51viz	275	43	.	.	.
cord-280878-1kt51viz	276	1	In	in	IN
cord-280878-1kt51viz	276	2	these	these	DT
cord-280878-1kt51viz	276	3	trials	trial	NNS
cord-280878-1kt51viz	276	4	,	,	,
cord-280878-1kt51viz	276	5	patients	patient	NNS
cord-280878-1kt51viz	276	6	received	receive	VBD
cord-280878-1kt51viz	276	7	400	400	CD
cord-280878-1kt51viz	276	8	mg	mg	NN
cord-280878-1kt51viz	276	9	of	of	IN
cord-280878-1kt51viz	276	10	BIT225	BIT225	NNP
cord-280878-1kt51viz	276	11	twice	twice	RB
cord-280878-1kt51viz	276	12	daily	daily	RB
cord-280878-1kt51viz	276	13	for	for	IN
cord-280878-1kt51viz	276	14	3	3	CD
cord-280878-1kt51viz	276	15	months	month	NNS
cord-280878-1kt51viz	276	16	.	.	.
cord-280878-1kt51viz	277	1	A	a	DT
cord-280878-1kt51viz	277	2	phase	phase	NN
cord-280878-1kt51viz	277	3	2a	2a	CD
cord-280878-1kt51viz	277	4	trial	trial	NN
cord-280878-1kt51viz	277	5	on	on	IN
cord-280878-1kt51viz	277	6	HCV	HCV	NNP
cord-280878-1kt51viz	277	7	demonstrated	demonstrate	VBD
cord-280878-1kt51viz	277	8	that	that	IN
cord-280878-1kt51viz	277	9	100	100	CD
cord-280878-1kt51viz	277	10	%	%	NN
cord-280878-1kt51viz	277	11	of	of	IN
cord-280878-1kt51viz	277	12	the	the	DT
cord-280878-1kt51viz	277	13	patients	patient	NNS
cord-280878-1kt51viz	277	14	infected	infect	VBN
cord-280878-1kt51viz	277	15	with	with	IN
cord-280878-1kt51viz	277	16	HCV	HCV	NNP
cord-280878-1kt51viz	277	17	GT1	GT1	NNP
cord-280878-1kt51viz	277	18	who	who	WP
cord-280878-1kt51viz	277	19	received	receive	VBD
cord-280878-1kt51viz	277	20	BIT225	BIT225	NNP
cord-280878-1kt51viz	277	21	(	(	-LRB-
cord-280878-1kt51viz	277	22	400	400	CD
cord-280878-1kt51viz	277	23	mg	mg	NNP
cord-280878-1kt51viz	277	24	)	)	-RRB-
cord-280878-1kt51viz	277	25	in	in	IN
cord-280878-1kt51viz	277	26	combination	combination	NN
cord-280878-1kt51viz	277	27	with	with	IN
cord-280878-1kt51viz	277	28	current	current	JJ
cord-280878-1kt51viz	277	29	standard	standard	NN
cord-280878-1kt51viz	277	30	of	of	IN
cord-280878-1kt51viz	277	31	care	care	NN
cord-280878-1kt51viz	277	32	therapies	therapy	NNS
cord-280878-1kt51viz	277	33	,	,	,
cord-280878-1kt51viz	277	34	IFN	IFN	NNP
cord-280878-1kt51viz	277	35	/	/	SYM
cord-280878-1kt51viz	277	36	RBV	RBV	NNP
cord-280878-1kt51viz	277	37	,	,	,
cord-280878-1kt51viz	277	38	had	have	VBD
cord-280878-1kt51viz	277	39	undetectable	undetectable	JJ
cord-280878-1kt51viz	277	40	virus	virus	NN
cord-280878-1kt51viz	277	41	after	after	IN
cord-280878-1kt51viz	277	42	48	48	CD
cord-280878-1kt51viz	277	43	weeks	week	NNS
cord-280878-1kt51viz	277	44	.	.	.
cord-280878-1kt51viz	278	1	A	a	DT
cord-280878-1kt51viz	278	2	phase	phase	NN
cord-280878-1kt51viz	278	3	2	2	CD
cord-280878-1kt51viz	278	4	trial	trial	NN
cord-280878-1kt51viz	278	5	in	in	IN
cord-280878-1kt51viz	278	6	HIV	HIV	NNP
cord-280878-1kt51viz	278	7	/	/	SYM
cord-280878-1kt51viz	278	8	HCV	HCV	NNP
cord-280878-1kt51viz	278	9	coinfected	coinfecte	VBD
cord-280878-1kt51viz	278	10	patients	patient	NNS
cord-280878-1kt51viz	278	11	showed	show	VBD
cord-280878-1kt51viz	278	12	that	that	IN
cord-280878-1kt51viz	278	13	all	all	DT
cord-280878-1kt51viz	278	14	HCV	HCV	NNP
cord-280878-1kt51viz	278	15	GT3	GT3	NNP
cord-280878-1kt51viz	278	16	patients	patient	NNS
cord-280878-1kt51viz	278	17	completing	complete	VBG
cord-280878-1kt51viz	278	18	28	28	CD
cord-280878-1kt51viz	278	19	days	day	NNS
cord-280878-1kt51viz	278	20	of	of	IN
cord-280878-1kt51viz	278	21	treatment	treatment	NN
cord-280878-1kt51viz	278	22	with	with	IN
cord-280878-1kt51viz	278	23	BIT225	BIT225	NNP
cord-280878-1kt51viz	278	24	in	in	IN
cord-280878-1kt51viz	278	25	combination	combination	NN
cord-280878-1kt51viz	278	26	with	with	IN
cord-280878-1kt51viz	278	27	IFN	IFN	NNP
cord-280878-1kt51viz	278	28	/	/	SYM
cord-280878-1kt51viz	278	29	RBV	RBV	NNP
cord-280878-1kt51viz	278	30	have	have	VBP
cord-280878-1kt51viz	278	31	undetectable	undetectable	JJ
cord-280878-1kt51viz	278	32	HCV	HCV	NNP
cord-280878-1kt51viz	278	33	load	load	NN
cord-280878-1kt51viz	278	34	for	for	IN
cord-280878-1kt51viz	278	35	12	12	CD
cord-280878-1kt51viz	278	36	weeks	week	NNS
cord-280878-1kt51viz	278	37	(	(	-LRB-
cord-280878-1kt51viz	278	38	sustained	sustain	VBN
cord-280878-1kt51viz	278	39	viral	viral	JJ
cord-280878-1kt51viz	278	40	response	response	NN
cord-280878-1kt51viz	278	41	,	,	,
cord-280878-1kt51viz	278	42	SVR12	SVR12	NNP
cord-280878-1kt51viz	278	43	)	)	-RRB-
cord-280878-1kt51viz	278	44	after	after	IN
cord-280878-1kt51viz	278	45	completing	complete	VBG
cord-280878-1kt51viz	278	46	all	all	DT
cord-280878-1kt51viz	278	47	therapy	therapy	NN
cord-280878-1kt51viz	278	48	.	.	.
cord-280878-1kt51viz	279	1	BIT225	BIT225	NNP
cord-280878-1kt51viz	279	2	is	be	VBZ
cord-280878-1kt51viz	279	3	also	also	RB
cord-280878-1kt51viz	279	4	in	in	IN
cord-280878-1kt51viz	279	5	development	development	NN
cord-280878-1kt51viz	279	6	for	for	IN
cord-280878-1kt51viz	279	7	treatment	treatment	NN
cord-280878-1kt51viz	279	8	of	of	IN
cord-280878-1kt51viz	279	9	HIV	HIV	NNP
cord-280878-1kt51viz	279	10	,	,	,
cord-280878-1kt51viz	279	11	and	and	CC
cord-280878-1kt51viz	279	12	is	be	VBZ
cord-280878-1kt51viz	279	13	the	the	DT
cord-280878-1kt51viz	279	14	pioneer	pioneer	NN
cord-280878-1kt51viz	279	15	in	in	IN
cord-280878-1kt51viz	279	16	a	a	DT
cord-280878-1kt51viz	279	17	new	new	JJ
cord-280878-1kt51viz	279	18	class	class	NN
cord-280878-1kt51viz	279	19	of	of	IN
cord-280878-1kt51viz	279	20	antiviral	antiviral	JJ
cord-280878-1kt51viz	279	21	drugs	drug	NNS
cord-280878-1kt51viz	279	22	that	that	WDT
cord-280878-1kt51viz	279	23	may	may	MD
cord-280878-1kt51viz	279	24	provide	provide	VB
cord-280878-1kt51viz	279	25	a	a	DT
cord-280878-1kt51viz	279	26	new	new	JJ
cord-280878-1kt51viz	279	27	approach	approach	NN
cord-280878-1kt51viz	279	28	to	to	IN
cord-280878-1kt51viz	279	29	the	the	DT
cord-280878-1kt51viz	279	30	eradication	eradication	NN
cord-280878-1kt51viz	279	31	of	of	IN
cord-280878-1kt51viz	279	32	this	this	DT
cord-280878-1kt51viz	279	33	virus	virus	NN
cord-280878-1kt51viz	279	34	.	.	.
cord-280878-1kt51viz	280	1	It	-PRON-	PRP
cord-280878-1kt51viz	280	2	has	have	VBZ
cord-280878-1kt51viz	280	3	shown	show	VBN
cord-280878-1kt51viz	280	4	clinical	clinical	JJ
cord-280878-1kt51viz	280	5	efficacy	efficacy	NN
cord-280878-1kt51viz	280	6	against	against	IN
cord-280878-1kt51viz	280	7	HIV	HIV	NNP
cord-280878-1kt51viz	280	8	in	in	IN
cord-280878-1kt51viz	280	9	reservoir	reservoir	NN
cord-280878-1kt51viz	280	10	cells	cell	NNS
cord-280878-1kt51viz	280	11	,	,	,
cord-280878-1kt51viz	280	12	and	and	CC
cord-280878-1kt51viz	280	13	has	have	VBZ
cord-280878-1kt51viz	280	14	the	the	DT
cord-280878-1kt51viz	280	15	potential	potential	NN
cord-280878-1kt51viz	280	16	to	to	TO
cord-280878-1kt51viz	280	17	be	be	VB
cord-280878-1kt51viz	280	18	combined	combine	VBN
cord-280878-1kt51viz	280	19	with	with	IN
cord-280878-1kt51viz	280	20	new	new	JJ
cord-280878-1kt51viz	280	21	or	or	CC
cord-280878-1kt51viz	280	22	existing	exist	VBG
cord-280878-1kt51viz	280	23	antiretroviral	antiretroviral	JJ
cord-280878-1kt51viz	280	24	drugs	drug	NNS
cord-280878-1kt51viz	280	25	to	to	TO
cord-280878-1kt51viz	280	26	eradicate	eradicate	VB
cord-280878-1kt51viz	280	27	long	long	RB
cord-280878-1kt51viz	280	28	-	-	HYPH
cord-280878-1kt51viz	280	29	lived	live	VBN
cord-280878-1kt51viz	280	30	pools	pool	NNS
cord-280878-1kt51viz	280	31	of	of	IN
cord-280878-1kt51viz	280	32	virus	virus	NN
cord-280878-1kt51viz	280	33	that	that	WDT
cord-280878-1kt51viz	280	34	are	be	VBP
cord-280878-1kt51viz	280	35	not	not	RB
cord-280878-1kt51viz	280	36	successfully	successfully	RB
cord-280878-1kt51viz	280	37	eliminated	eliminate	VBN
cord-280878-1kt51viz	280	38	with	with	IN
cord-280878-1kt51viz	280	39	current	current	JJ
cord-280878-1kt51viz	280	40	treatments	treatment	NNS
cord-280878-1kt51viz	280	41	.	.	.
cord-280878-1kt51viz	281	1	Despite	despite	IN
cord-280878-1kt51viz	281	2	these	these	DT
cord-280878-1kt51viz	281	3	promising	promising	JJ
cord-280878-1kt51viz	281	4	results	result	NNS
cord-280878-1kt51viz	281	5	,	,	,
cord-280878-1kt51viz	281	6	however	however	RB
cord-280878-1kt51viz	281	7	,	,	,
cord-280878-1kt51viz	281	8	it	-PRON-	PRP
cord-280878-1kt51viz	281	9	remains	remain	VBZ
cord-280878-1kt51viz	281	10	to	to	TO
cord-280878-1kt51viz	281	11	be	be	VB
cord-280878-1kt51viz	281	12	demonstrated	demonstrate	VBN
cord-280878-1kt51viz	281	13	that	that	IN
cord-280878-1kt51viz	281	14	BIT225	bit225	JJ
cord-280878-1kt51viz	281	15	targets	target	NNS
cord-280878-1kt51viz	281	16	p7	p7	RB
cord-280878-1kt51viz	281	17	or	or	CC
cord-280878-1kt51viz	281	18	Vpu	Vpu	NNPS
cord-280878-1kt51viz	281	19	in	in	IN
cord-280878-1kt51viz	281	20	infected	infected	JJ
cord-280878-1kt51viz	281	21	cells	cell	NNS
cord-280878-1kt51viz	281	22	.	.	.
cord-280878-1kt51viz	282	1	The	the	DT
cord-280878-1kt51viz	282	2	most	most	RBS
cord-280878-1kt51viz	282	3	studied	study	VBN
cord-280878-1kt51viz	282	4	viroporin	viroporin	NN
cord-280878-1kt51viz	282	5	in	in	IN
cord-280878-1kt51viz	282	6	coronaviruses	coronaviruse	NNS
cord-280878-1kt51viz	282	7	is	be	VBZ
cord-280878-1kt51viz	282	8	the	the	DT
cord-280878-1kt51viz	282	9	envelope	envelope	NN
cord-280878-1kt51viz	282	10	(	(	-LRB-
cord-280878-1kt51viz	282	11	E	e	NN
cord-280878-1kt51viz	282	12	)	)	-RRB-
cord-280878-1kt51viz	282	13	protein	protein	NN
cord-280878-1kt51viz	282	14	.	.	.
cord-280878-1kt51viz	283	1	Coronaviruses	Coronaviruses	NNP
cord-280878-1kt51viz	283	2	(	(	-LRB-
cord-280878-1kt51viz	283	3	CoV	CoV	NNP
cord-280878-1kt51viz	283	4	)	)	-RRB-
cord-280878-1kt51viz	283	5	typically	typically	RB
cord-280878-1kt51viz	283	6	affect	affect	VBP
cord-280878-1kt51viz	283	7	the	the	DT
cord-280878-1kt51viz	283	8	respiratory	respiratory	JJ
cord-280878-1kt51viz	283	9	tract	tract	NN
cord-280878-1kt51viz	283	10	and	and	CC
cord-280878-1kt51viz	283	11	gut	gut	NN
cord-280878-1kt51viz	283	12	of	of	IN
cord-280878-1kt51viz	283	13	mammals	mammal	NNS
cord-280878-1kt51viz	283	14	and	and	CC
cord-280878-1kt51viz	283	15	birds	bird	NNS
cord-280878-1kt51viz	283	16	.	.	.
cord-280878-1kt51viz	284	1	CoVs	CoVs	NNP
cord-280878-1kt51viz	284	2	belong	belong	VBP
cord-280878-1kt51viz	284	3	to	to	IN
cord-280878-1kt51viz	284	4	the	the	DT
cord-280878-1kt51viz	284	5	subfamily	subfamily	NN
cord-280878-1kt51viz	284	6	Coronavirinae	Coronavirinae	NNP
cord-280878-1kt51viz	284	7	in	in	IN
cord-280878-1kt51viz	284	8	the	the	DT
cord-280878-1kt51viz	284	9	family	family	NN
cord-280878-1kt51viz	284	10	Coronaviridae	Coronaviridae	NNP
cord-280878-1kt51viz	284	11	,	,	,
cord-280878-1kt51viz	284	12	and	and	CC
cord-280878-1kt51viz	284	13	are	be	VBP
cord-280878-1kt51viz	284	14	organized	organize	VBN
cord-280878-1kt51viz	284	15	into	into	IN
cord-280878-1kt51viz	284	16	four	four	CD
cord-280878-1kt51viz	284	17	genera	genus	NNS
cord-280878-1kt51viz	284	18	(	(	-LRB-
cord-280878-1kt51viz	284	19	Enjuanes	Enjuanes	NNP
cord-280878-1kt51viz	284	20	et	et	NNP
cord-280878-1kt51viz	284	21	al	al	NNP
cord-280878-1kt51viz	284	22	.	.	NNP
cord-280878-1kt51viz	284	23	,	,	,
cord-280878-1kt51viz	284	24	2000	2000	CD
cord-280878-1kt51viz	284	25	)	)	-RRB-
cord-280878-1kt51viz	284	26	:	:	:
cord-280878-1kt51viz	284	27	α	α	NNP
cord-280878-1kt51viz	284	28	,	,	,
cord-280878-1kt51viz	284	29	β	β	NN
cord-280878-1kt51viz	284	30	,	,	,
cord-280878-1kt51viz	284	31	γ	γ	NNP
cord-280878-1kt51viz	284	32	,	,	,
cord-280878-1kt51viz	284	33	and	and	CC
cord-280878-1kt51viz	284	34	δ	δ	NN
cord-280878-1kt51viz	284	35	.	.	.
cord-280878-1kt51viz	285	1	Approximately	approximately	RB
cord-280878-1kt51viz	285	2	30	30	CD
cord-280878-1kt51viz	285	3	%	%	NN
cord-280878-1kt51viz	285	4	of	of	IN
cord-280878-1kt51viz	285	5	common	common	JJ
cord-280878-1kt51viz	285	6	colds	cold	NNS
cord-280878-1kt51viz	285	7	are	be	VBP
cord-280878-1kt51viz	285	8	caused	cause	VBN
cord-280878-1kt51viz	285	9	by	by	IN
cord-280878-1kt51viz	285	10	two	two	CD
cord-280878-1kt51viz	285	11	human	human	JJ
cord-280878-1kt51viz	285	12	coronaviruses	coronaviruse	NNS
cord-280878-1kt51viz	285	13	-	-	HYPH
cord-280878-1kt51viz	285	14	OC43	OC43	NNP
cord-280878-1kt51viz	285	15	and	and	CC
cord-280878-1kt51viz	285	16	229E.	229e.	NN
cord-280878-1kt51viz	285	17	Of	of	IN
cord-280878-1kt51viz	285	18	particular	particular	JJ
cord-280878-1kt51viz	285	19	medical	medical	JJ
cord-280878-1kt51viz	285	20	interest	interest	NN
cord-280878-1kt51viz	285	21	is	be	VBZ
cord-280878-1kt51viz	285	22	the	the	DT
cord-280878-1kt51viz	285	23	virus	virus	NN
cord-280878-1kt51viz	285	24	responsible	responsible	JJ
cord-280878-1kt51viz	285	25	for	for	IN
cord-280878-1kt51viz	285	26	the	the	DT
cord-280878-1kt51viz	285	27	severe	severe	JJ
cord-280878-1kt51viz	285	28	acute	acute	JJ
cord-280878-1kt51viz	285	29	respiratory	respiratory	JJ
cord-280878-1kt51viz	285	30	syndrome	syndrome	NN
cord-280878-1kt51viz	285	31	(	(	-LRB-
cord-280878-1kt51viz	285	32	SARS	SARS	NNP
cord-280878-1kt51viz	285	33	)	)	-RRB-
cord-280878-1kt51viz	285	34	,	,	,
cord-280878-1kt51viz	285	35	which	which	WDT
cord-280878-1kt51viz	285	36	produced	produce	VBD
cord-280878-1kt51viz	285	37	a	a	DT
cord-280878-1kt51viz	285	38	near	near	JJ
cord-280878-1kt51viz	285	39	pandemic	pandemic	NN
cord-280878-1kt51viz	285	40	in	in	IN
cord-280878-1kt51viz	285	41	2003	2003	CD
cord-280878-1kt51viz	285	42	(	(	-LRB-
cord-280878-1kt51viz	285	43	Holmes	Holmes	NNP
cord-280878-1kt51viz	285	44	,	,	,
cord-280878-1kt51viz	285	45	2003	2003	CD
cord-280878-1kt51viz	285	46	)	)	-RRB-
cord-280878-1kt51viz	285	47	,	,	,
cord-280878-1kt51viz	285	48	and	and	CC
cord-280878-1kt51viz	285	49	the	the	DT
cord-280878-1kt51viz	285	50	recently	recently	RB
cord-280878-1kt51viz	285	51	emerged	emerge	VBN
cord-280878-1kt51viz	285	52	Middle	Middle	NNP
cord-280878-1kt51viz	285	53	East	East	NNP
cord-280878-1kt51viz	285	54	respiratory	respiratory	JJ
cord-280878-1kt51viz	285	55	syndrome	syndrome	NN
cord-280878-1kt51viz	285	56	coronavirus	coronavirus	NN
cord-280878-1kt51viz	285	57	(	(	-LRB-
cord-280878-1kt51viz	285	58	MERS	MERS	NNP
cord-280878-1kt51viz	285	59	-	-	HYPH
cord-280878-1kt51viz	285	60	CoV	CoV	NNP
cord-280878-1kt51viz	285	61	)	)	-RRB-
cord-280878-1kt51viz	285	62	,	,	,
cord-280878-1kt51viz	285	63	which	which	WDT
cord-280878-1kt51viz	285	64	after	after	IN
cord-280878-1kt51viz	285	65	3	3	CD
cord-280878-1kt51viz	285	66	years	year	NNS
cord-280878-1kt51viz	285	67	has	have	VBZ
cord-280878-1kt51viz	285	68	caused	cause	VBN
cord-280878-1kt51viz	285	69	hundreds	hundred	NNS
cord-280878-1kt51viz	285	70	of	of	IN
cord-280878-1kt51viz	285	71	deaths	death	NNS
cord-280878-1kt51viz	285	72	(	(	-LRB-
cord-280878-1kt51viz	285	73	Raj	Raj	NNP
cord-280878-1kt51viz	285	74	,	,	,
cord-280878-1kt51viz	285	75	Osterhaus	Osterhaus	NNP
cord-280878-1kt51viz	285	76	,	,	,
cord-280878-1kt51viz	285	77	Fouchier	Fouchier	NNP
cord-280878-1kt51viz	285	78	,	,	,
cord-280878-1kt51viz	285	79	&	&	CC
cord-280878-1kt51viz	285	80	Haagmans	Haagmans	NNPS
cord-280878-1kt51viz	285	81	,	,	,
cord-280878-1kt51viz	285	82	2014	2014	CD
cord-280878-1kt51viz	285	83	)	)	-RRB-
cord-280878-1kt51viz	285	84	.	.	.
cord-280878-1kt51viz	286	1	Other	other	JJ
cord-280878-1kt51viz	286	2	coronavirus	coronavirus	NN
cord-280878-1kt51viz	286	3	viroporins	viroporin	NNS
cord-280878-1kt51viz	286	4	,	,	,
cord-280878-1kt51viz	286	5	eg	eg	XX
cord-280878-1kt51viz	286	6	,	,	,
cord-280878-1kt51viz	286	7	the	the	DT
cord-280878-1kt51viz	286	8	SARS	SARS	NNP
cord-280878-1kt51viz	286	9	-	-	HYPH
cord-280878-1kt51viz	286	10	CoV3a	CoV3a	NNP
cord-280878-1kt51viz	286	11	(	(	-LRB-
cord-280878-1kt51viz	287	1	Lu	Lu	NNP
cord-280878-1kt51viz	287	2	et	et	FW
cord-280878-1kt51viz	287	3	al	al	NNP
cord-280878-1kt51viz	287	4	.	.	NNP
cord-280878-1kt51viz	287	5	,	,	,
cord-280878-1kt51viz	287	6	2006	2006	CD
cord-280878-1kt51viz	287	7	)	)	-RRB-
cord-280878-1kt51viz	287	8	,	,	,
cord-280878-1kt51viz	287	9	a	a	DT
cord-280878-1kt51viz	287	10	274-amino	274-amino	CD
cord-280878-1kt51viz	287	11	acid	acid	NN
cord-280878-1kt51viz	287	12	protein	protein	NN
cord-280878-1kt51viz	287	13	with	with	IN
cord-280878-1kt51viz	287	14	three	three	CD
cord-280878-1kt51viz	287	15	putative	putative	JJ
cord-280878-1kt51viz	287	16	TM	TM	NNP
cord-280878-1kt51viz	287	17	domains	domain	NNS
cord-280878-1kt51viz	287	18	,	,	,
cord-280878-1kt51viz	287	19	are	be	VBP
cord-280878-1kt51viz	287	20	also	also	RB
cord-280878-1kt51viz	287	21	attracting	attract	VBG
cord-280878-1kt51viz	287	22	increasing	increase	VBG
cord-280878-1kt51viz	287	23	interest	interest	NN
cord-280878-1kt51viz	288	1	(	(	-LRB-
cord-280878-1kt51viz	288	2	Chien	Chien	NNP
cord-280878-1kt51viz	288	3	et	et	FW
cord-280878-1kt51viz	288	4	al	al	NNP
cord-280878-1kt51viz	288	5	.	.	.
cord-280878-1kt51viz	289	1	,	,	,
cord-280878-1kt51viz	289	2	2013	2013	CD
cord-280878-1kt51viz	289	3	;	;	:
cord-280878-1kt51viz	289	4	Hsu	Hsu	NNP
cord-280878-1kt51viz	289	5	&	&	CC
cord-280878-1kt51viz	289	6	Fischer	Fischer	NNP
cord-280878-1kt51viz	289	7	,	,	,
cord-280878-1kt51viz	289	8	2012	2012	CD
cord-280878-1kt51viz	289	9	)	)	-RRB-
cord-280878-1kt51viz	289	10	,	,	,
cord-280878-1kt51viz	289	11	but	but	CC
cord-280878-1kt51viz	289	12	no	no	DT
cord-280878-1kt51viz	289	13	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	289	14	or	or	CC
cord-280878-1kt51viz	289	15	structural	structural	JJ
cord-280878-1kt51viz	289	16	data	data	NN
cord-280878-1kt51viz	289	17	is	be	VBZ
cord-280878-1kt51viz	289	18	available	available	JJ
cord-280878-1kt51viz	289	19	so	so	RB
cord-280878-1kt51viz	289	20	far	far	RB
cord-280878-1kt51viz	289	21	.	.	.
cord-280878-1kt51viz	290	1	Currently	currently	RB
cord-280878-1kt51viz	290	2	,	,	,
cord-280878-1kt51viz	290	3	no	no	DT
cord-280878-1kt51viz	290	4	effective	effective	JJ
cord-280878-1kt51viz	290	5	licensed	license	VBN
cord-280878-1kt51viz	290	6	treatment	treatment	NN
cord-280878-1kt51viz	290	7	exist	exist	VBP
cord-280878-1kt51viz	290	8	against	against	IN
cord-280878-1kt51viz	290	9	coronavirus	coronavirus	NN
cord-280878-1kt51viz	290	10	infection	infection	NN
cord-280878-1kt51viz	290	11	(	(	-LRB-
cord-280878-1kt51viz	290	12	Kilianski	Kilianski	NNP
cord-280878-1kt51viz	290	13	&	&	CC
cord-280878-1kt51viz	290	14	Baker	Baker	NNP
cord-280878-1kt51viz	290	15	,	,	,
cord-280878-1kt51viz	290	16	2014	2014	CD
cord-280878-1kt51viz	290	17	;	;	:
cord-280878-1kt51viz	290	18	Kilianski	Kilianski	NNP
cord-280878-1kt51viz	290	19	,	,	,
cord-280878-1kt51viz	290	20	Mielech	Mielech	NNP
cord-280878-1kt51viz	290	21	,	,	,
cord-280878-1kt51viz	290	22	Deng	Deng	NNP
cord-280878-1kt51viz	290	23	,	,	,
cord-280878-1kt51viz	290	24	&	&	CC
cord-280878-1kt51viz	290	25	Baker	Baker	NNP
cord-280878-1kt51viz	290	26	,	,	,
cord-280878-1kt51viz	290	27	2013	2013	CD
cord-280878-1kt51viz	290	28	;	;	:
cord-280878-1kt51viz	290	29	Lou	Lou	NNP
cord-280878-1kt51viz	290	30	,	,	,
cord-280878-1kt51viz	290	31	Sun	Sun	NNP
cord-280878-1kt51viz	290	32	,	,	,
cord-280878-1kt51viz	290	33	&	&	CC
cord-280878-1kt51viz	290	34	Rao	Rao	NNP
cord-280878-1kt51viz	290	35	,	,	,
cord-280878-1kt51viz	290	36	2014	2014	CD
cord-280878-1kt51viz	290	37	)	)	-RRB-
cord-280878-1kt51viz	290	38	,	,	,
cord-280878-1kt51viz	290	39	although	although	IN
cord-280878-1kt51viz	290	40	live	live	JJ
cord-280878-1kt51viz	290	41	vaccines	vaccine	NNS
cord-280878-1kt51viz	290	42	consisting	consist	VBG
cord-280878-1kt51viz	290	43	of	of	IN
cord-280878-1kt51viz	290	44	attenuated	attenuated	JJ
cord-280878-1kt51viz	290	45	viruses	virus	NNS
cord-280878-1kt51viz	290	46	is	be	VBZ
cord-280878-1kt51viz	290	47	a	a	DT
cord-280878-1kt51viz	290	48	promising	promising	JJ
cord-280878-1kt51viz	290	49	strategy	strategy	NN
cord-280878-1kt51viz	290	50	(	(	-LRB-
cord-280878-1kt51viz	290	51	Enjuanes	Enjuanes	NNP
cord-280878-1kt51viz	290	52	,	,	,
cord-280878-1kt51viz	290	53	Nieto	Nieto	NNP
cord-280878-1kt51viz	290	54	-	-	HYPH
cord-280878-1kt51viz	290	55	Torres	Torres	NNP
cord-280878-1kt51viz	290	56	,	,	,
cord-280878-1kt51viz	290	57	Jimenez	Jimenez	NNP
cord-280878-1kt51viz	290	58	-	-	HYPH
cord-280878-1kt51viz	290	59	Guardeno	Guardeno	NNP
cord-280878-1kt51viz	290	60	,	,	,
cord-280878-1kt51viz	290	61	&	&	CC
cord-280878-1kt51viz	290	62	DeDiego	DeDiego	NNP
cord-280878-1kt51viz	290	63	,	,	,
cord-280878-1kt51viz	290	64	2011	2011	CD
cord-280878-1kt51viz	290	65	;	;	:
cord-280878-1kt51viz	291	1	Graham	Graham	NNP
cord-280878-1kt51viz	291	2	et	et	NNP
cord-280878-1kt51viz	291	3	al	al	NNP
cord-280878-1kt51viz	291	4	.	.	NNP
cord-280878-1kt51viz	291	5	,	,	,
cord-280878-1kt51viz	291	6	2012	2012	CD
cord-280878-1kt51viz	291	7	)	)	-RRB-
cord-280878-1kt51viz	291	8	,	,	,
cord-280878-1kt51viz	291	9	along	along	IN
cord-280878-1kt51viz	291	10	with	with	IN
cord-280878-1kt51viz	291	11	fusion	fusion	NN
cord-280878-1kt51viz	291	12	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	291	13	(	(	-LRB-
cord-280878-1kt51viz	291	14	reviewed	review	VBN
cord-280878-1kt51viz	291	15	in	in	IN
cord-280878-1kt51viz	291	16	Heald	Heald	NNP
cord-280878-1kt51viz	291	17	-	-	HYPH
cord-280878-1kt51viz	291	18	Sargent	Sargent	NNP
cord-280878-1kt51viz	291	19	&	&	CC
cord-280878-1kt51viz	291	20	Gallagher	Gallagher	NNP
cord-280878-1kt51viz	291	21	,	,	,
cord-280878-1kt51viz	291	22	2012	2012	CD
cord-280878-1kt51viz	291	23	)	)	-RRB-
cord-280878-1kt51viz	291	24	.	.	.
cord-280878-1kt51viz	292	1	Even	even	RB
cord-280878-1kt51viz	292	2	so	so	RB
cord-280878-1kt51viz	292	3	,	,	,
cord-280878-1kt51viz	292	4	the	the	DT
cord-280878-1kt51viz	292	5	possibility	possibility	NN
cord-280878-1kt51viz	292	6	of	of	IN
cord-280878-1kt51viz	292	7	reappearance	reappearance	NN
cord-280878-1kt51viz	292	8	of	of	IN
cord-280878-1kt51viz	292	9	virulent	virulent	JJ
cord-280878-1kt51viz	292	10	phenotypes	phenotype	NNS
cord-280878-1kt51viz	292	11	,	,	,
cord-280878-1kt51viz	292	12	drug	drug	NN
cord-280878-1kt51viz	292	13	side	side	NN
cord-280878-1kt51viz	292	14	effects	effect	NNS
cord-280878-1kt51viz	292	15	,	,	,
cord-280878-1kt51viz	292	16	and	and	CC
cord-280878-1kt51viz	292	17	resistance	resistance	NN
cord-280878-1kt51viz	292	18	calls	call	NNS
cord-280878-1kt51viz	292	19	for	for	IN
cord-280878-1kt51viz	292	20	continued	continued	JJ
cord-280878-1kt51viz	292	21	antiviral	antiviral	JJ
cord-280878-1kt51viz	292	22	development	development	NN
cord-280878-1kt51viz	292	23	.	.	.
cord-280878-1kt51viz	293	1	The	the	DT
cord-280878-1kt51viz	293	2	envelope	envelope	NN
cord-280878-1kt51viz	293	3	(	(	-LRB-
cord-280878-1kt51viz	293	4	E	e	NN
cord-280878-1kt51viz	293	5	)	)	-RRB-
cord-280878-1kt51viz	293	6	proteins	protein	NNS
cord-280878-1kt51viz	293	7	are	be	VBP
cord-280878-1kt51viz	293	8	76	76	CD
cord-280878-1kt51viz	293	9	-	-	SYM
cord-280878-1kt51viz	293	10	109	109	CD
cord-280878-1kt51viz	293	11	residues	residue	NNS
cord-280878-1kt51viz	293	12	long	long	RB
cord-280878-1kt51viz	293	13	with	with	IN
cord-280878-1kt51viz	293	14	one	one	CD
cord-280878-1kt51viz	293	15	TM	TM	NNP
cord-280878-1kt51viz	293	16	domain	domain	NN
cord-280878-1kt51viz	293	17	(	(	-LRB-
cord-280878-1kt51viz	293	18	Li	Li	NNP
cord-280878-1kt51viz	293	19	,	,	,
cord-280878-1kt51viz	293	20	Surya	Surya	NNP
cord-280878-1kt51viz	293	21	,	,	,
cord-280878-1kt51viz	293	22	Claudine	Claudine	NNP
cord-280878-1kt51viz	293	23	,	,	,
cord-280878-1kt51viz	293	24	&	&	CC
cord-280878-1kt51viz	293	25	Torres	Torres	NNP
cord-280878-1kt51viz	293	26	,	,	,
cord-280878-1kt51viz	293	27	2014	2014	CD
cord-280878-1kt51viz	293	28	;	;	.
cord-280878-1kt51viz	294	1	Parthasarathy	Parthasarathy	NNP
cord-280878-1kt51viz	294	2	et	et	NNP
cord-280878-1kt51viz	294	3	al	al	NNP
cord-280878-1kt51viz	294	4	.	.	.
cord-280878-1kt51viz	295	1	,	,	,
cord-280878-1kt51viz	295	2	2008	2008	CD
cord-280878-1kt51viz	296	1	Parthasarathy	Parthasarathy	NNP
cord-280878-1kt51viz	296	2	et	et	NNP
cord-280878-1kt51viz	296	3	al	al	NNP
cord-280878-1kt51viz	296	4	.	.	.
cord-280878-1kt51viz	297	1	,	,	,
cord-280878-1kt51viz	297	2	,	,	,
cord-280878-1kt51viz	297	3	2012	2012	CD
cord-280878-1kt51viz	297	4	Pervushin	Pervushin	NNP
cord-280878-1kt51viz	297	5	et	et	NNP
cord-280878-1kt51viz	297	6	al	al	NNP
cord-280878-1kt51viz	297	7	.	.	NNP
cord-280878-1kt51viz	297	8	,	,	,
cord-280878-1kt51viz	297	9	2009	2009	CD
cord-280878-1kt51viz	297	10	;	;	:
cord-280878-1kt51viz	297	11	Torres	Torres	NNP
cord-280878-1kt51viz	297	12	et	et	NNP
cord-280878-1kt51viz	297	13	al	al	NNP
cord-280878-1kt51viz	297	14	.	.	NNP
cord-280878-1kt51viz	297	15	,	,	,
cord-280878-1kt51viz	297	16	2006	2006	CD
cord-280878-1kt51viz	298	1	;	;	:
cord-280878-1kt51viz	298	2	Torres	Torres	NNP
cord-280878-1kt51viz	298	3	,	,	,
cord-280878-1kt51viz	298	4	Wang	Wang	NNP
cord-280878-1kt51viz	298	5	,	,	,
cord-280878-1kt51viz	298	6	Parthasarathy	Parthasarathy	NNP
cord-280878-1kt51viz	298	7	,	,	,
cord-280878-1kt51viz	298	8	&	&	CC
cord-280878-1kt51viz	298	9	Liu	Liu	NNP
cord-280878-1kt51viz	298	10	,	,	,
cord-280878-1kt51viz	298	11	2005	2005	CD
cord-280878-1kt51viz	298	12	)	)	-RRB-
cord-280878-1kt51viz	298	13	,	,	,
cord-280878-1kt51viz	298	14	and	and	CC
cord-280878-1kt51viz	298	15	most	most	JJS
cord-280878-1kt51viz	298	16	of	of	IN
cord-280878-1kt51viz	298	17	them	-PRON-	PRP
cord-280878-1kt51viz	298	18	have	have	VBP
cord-280878-1kt51viz	298	19	a	a	DT
cord-280878-1kt51viz	298	20	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	298	21	C	c	NN
cord-280878-1kt51viz	298	22	-	-	HYPH
cord-280878-1kt51viz	298	23	terminal	terminal	NN
cord-280878-1kt51viz	298	24	domain	domain	NN
cord-280878-1kt51viz	298	25	and	and	CC
cord-280878-1kt51viz	298	26	a	a	DT
cord-280878-1kt51viz	298	27	lumenal	lumenal	JJ
cord-280878-1kt51viz	298	28	N	n	CD
cord-280878-1kt51viz	298	29	-	-	HYPH
cord-280878-1kt51viz	298	30	terminus	terminus	NN
cord-280878-1kt51viz	298	31	(	(	-LRB-
cord-280878-1kt51viz	298	32	Corse	Corse	NNP
cord-280878-1kt51viz	298	33	&	&	CC
cord-280878-1kt51viz	298	34	Machamer	Machamer	NNP
cord-280878-1kt51viz	298	35	,	,	,
cord-280878-1kt51viz	298	36	2000	2000	CD
cord-280878-1kt51viz	298	37	;	;	:
cord-280878-1kt51viz	298	38	Nieto	Nieto	NNP
cord-280878-1kt51viz	298	39	-	-	HYPH
cord-280878-1kt51viz	298	40	Torres	Torres	NNP
cord-280878-1kt51viz	298	41	et	et	NNP
cord-280878-1kt51viz	298	42	al	al	NNP
cord-280878-1kt51viz	298	43	.	.	NNP
cord-280878-1kt51viz	298	44	,	,	,
cord-280878-1kt51viz	298	45	2011	2011	CD
cord-280878-1kt51viz	298	46	;	;	:
cord-280878-1kt51viz	299	1	Raamsman	Raamsman	NNP
cord-280878-1kt51viz	299	2	et	et	FW
cord-280878-1kt51viz	299	3	al	al	NNP
cord-280878-1kt51viz	299	4	.	.	NNP
cord-280878-1kt51viz	299	5	,	,	,
cord-280878-1kt51viz	299	6	2000	2000	CD
cord-280878-1kt51viz	299	7	;	;	:
cord-280878-1kt51viz	299	8	Ruch	Ruch	NNP
cord-280878-1kt51viz	299	9	&	&	CC
cord-280878-1kt51viz	299	10	Machamer	Machamer	NNP
cord-280878-1kt51viz	299	11	,	,	,
cord-280878-1kt51viz	299	12	2012	2012	CD
cord-280878-1kt51viz	299	13	)	)	-RRB-
cord-280878-1kt51viz	299	14	.	.	.
cord-280878-1kt51viz	300	1	Most	Most	JJS
cord-280878-1kt51viz	300	2	CoV	cov	NN
cord-280878-1kt51viz	300	3	E	e	NN
cord-280878-1kt51viz	300	4	proteins	protein	NNS
cord-280878-1kt51viz	300	5	are	be	VBP
cord-280878-1kt51viz	300	6	present	present	JJ
cord-280878-1kt51viz	300	7	at	at	IN
cord-280878-1kt51viz	300	8	low	low	JJ
cord-280878-1kt51viz	300	9	concentrations	concentration	NNS
cord-280878-1kt51viz	300	10	in	in	IN
cord-280878-1kt51viz	300	11	virions	virion	NNS
cord-280878-1kt51viz	300	12	(	(	-LRB-
cord-280878-1kt51viz	300	13	Corse	Corse	NNP
cord-280878-1kt51viz	300	14	&	&	CC
cord-280878-1kt51viz	300	15	Machamer	Machamer	NNP
cord-280878-1kt51viz	300	16	,	,	,
cord-280878-1kt51viz	300	17	2000	2000	CD
cord-280878-1kt51viz	300	18	;	;	:
cord-280878-1kt51viz	300	19	Godet	Godet	NNP
cord-280878-1kt51viz	300	20	,	,	,
cord-280878-1kt51viz	300	21	L'Haridon	L'Haridon	NNP
cord-280878-1kt51viz	300	22	,	,	,
cord-280878-1kt51viz	300	23	Vautherot	Vautherot	NNP
cord-280878-1kt51viz	300	24	,	,	,
cord-280878-1kt51viz	300	25	&	&	CC
cord-280878-1kt51viz	300	26	Laude	Laude	NNP
cord-280878-1kt51viz	300	27	,	,	,
cord-280878-1kt51viz	300	28	1992	1992	CD
cord-280878-1kt51viz	300	29	;	;	:
cord-280878-1kt51viz	300	30	Liao	Liao	NNP
cord-280878-1kt51viz	300	31	,	,	,
cord-280878-1kt51viz	300	32	Yuan	Yuan	NNP
cord-280878-1kt51viz	300	33	,	,	,
cord-280878-1kt51viz	300	34	Torres	Torres	NNP
cord-280878-1kt51viz	300	35	,	,	,
cord-280878-1kt51viz	300	36	Tam	Tam	NNP
cord-280878-1kt51viz	300	37	,	,	,
cord-280878-1kt51viz	300	38	&	&	CC
cord-280878-1kt51viz	300	39	Liu	Liu	NNP
cord-280878-1kt51viz	300	40	,	,	,
cord-280878-1kt51viz	300	41	2006	2006	CD
cord-280878-1kt51viz	300	42	;	;	:
cord-280878-1kt51viz	300	43	Yu	Yu	NNP
cord-280878-1kt51viz	300	44	,	,	,
cord-280878-1kt51viz	300	45	Bi	Bi	NNP
cord-280878-1kt51viz	300	46	,	,	,
cord-280878-1kt51viz	300	47	Weiss	Weiss	NNP
cord-280878-1kt51viz	300	48	,	,	,
cord-280878-1kt51viz	300	49	&	&	CC
cord-280878-1kt51viz	300	50	Leibowitz	Leibowitz	NNP
cord-280878-1kt51viz	300	51	,	,	,
cord-280878-1kt51viz	300	52	1994	1994	CD
cord-280878-1kt51viz	300	53	)	)	-RRB-
cord-280878-1kt51viz	300	54	,	,	,
cord-280878-1kt51viz	300	55	but	but	CC
cord-280878-1kt51viz	300	56	found	find	VBN
cord-280878-1kt51viz	300	57	abundantly	abundantly	RB
cord-280878-1kt51viz	300	58	in	in	IN
cord-280878-1kt51viz	300	59	internal	internal	JJ
cord-280878-1kt51viz	300	60	membranes	membrane	NNS
cord-280878-1kt51viz	300	61	of	of	IN
cord-280878-1kt51viz	300	62	infected	infected	JJ
cord-280878-1kt51viz	300	63	hosts	host	NNS
cord-280878-1kt51viz	300	64	(	(	-LRB-
cord-280878-1kt51viz	300	65	Corse	Corse	NNP
cord-280878-1kt51viz	300	66	&	&	CC
cord-280878-1kt51viz	300	67	Machamer	Machamer	NNP
cord-280878-1kt51viz	300	68	,	,	,
cord-280878-1kt51viz	300	69	2003	2003	CD
cord-280878-1kt51viz	300	70	;	;	:
cord-280878-1kt51viz	300	71	Liao	Liao	NNP
cord-280878-1kt51viz	300	72	et	et	NNP
cord-280878-1kt51viz	300	73	al	al	NNP
cord-280878-1kt51viz	300	74	.	.	NNP
cord-280878-1kt51viz	300	75	,	,	,
cord-280878-1kt51viz	300	76	2006	2006	CD
cord-280878-1kt51viz	300	77	;	;	.
cord-280878-1kt51viz	301	1	Raamsman	Raamsman	NNP
cord-280878-1kt51viz	301	2	et	et	FW
cord-280878-1kt51viz	301	3	al	al	NNP
cord-280878-1kt51viz	301	4	.	.	NNP
cord-280878-1kt51viz	301	5	,	,	,
cord-280878-1kt51viz	301	6	2000	2000	CD
cord-280878-1kt51viz	302	1	;	;	:
cord-280878-1kt51viz	302	2	Tung	Tung	NNP
cord-280878-1kt51viz	302	3	et	et	NNP
cord-280878-1kt51viz	302	4	al	al	NNP
cord-280878-1kt51viz	302	5	.	.	NNP
cord-280878-1kt51viz	302	6	,	,	,
cord-280878-1kt51viz	302	7	1992	1992	CD
cord-280878-1kt51viz	302	8	)	)	-RRB-
cord-280878-1kt51viz	302	9	,	,	,
cord-280878-1kt51viz	302	10	eg	eg	XX
cord-280878-1kt51viz	302	11	,	,	,
cord-280878-1kt51viz	302	12	the	the	DT
cord-280878-1kt51viz	302	13	ER	ER	NNP
cord-280878-1kt51viz	302	14	-	-	HYPH
cord-280878-1kt51viz	302	15	Golgi	Golgi	NNP
cord-280878-1kt51viz	302	16	intermediate	intermediate	JJ
cord-280878-1kt51viz	302	17	compartment	compartment	NN
cord-280878-1kt51viz	302	18	(	(	-LRB-
cord-280878-1kt51viz	302	19	ERGIC	ERGIC	NNP
cord-280878-1kt51viz	302	20	)	)	-RRB-
cord-280878-1kt51viz	302	21	,	,	,
cord-280878-1kt51viz	302	22	where	where	WRB
cord-280878-1kt51viz	302	23	virions	virion	NNS
cord-280878-1kt51viz	302	24	assemble	assemble	VBP
cord-280878-1kt51viz	302	25	(	(	-LRB-
cord-280878-1kt51viz	302	26	Lopez	Lopez	NNP
cord-280878-1kt51viz	302	27	,	,	,
cord-280878-1kt51viz	302	28	Riffle	Riffle	NNP
cord-280878-1kt51viz	302	29	,	,	,
cord-280878-1kt51viz	302	30	Pike	Pike	NNP
cord-280878-1kt51viz	302	31	,	,	,
cord-280878-1kt51viz	302	32	Gardner	Gardner	NNP
cord-280878-1kt51viz	302	33	,	,	,
cord-280878-1kt51viz	302	34	&	&	CC
cord-280878-1kt51viz	302	35	Hogue	Hogue	NNP
cord-280878-1kt51viz	302	36	,	,	,
cord-280878-1kt51viz	302	37	2008	2008	CD
cord-280878-1kt51viz	302	38	;	;	.
cord-280878-1kt51viz	303	1	Nieto	Nieto	NNP
cord-280878-1kt51viz	303	2	-	-	HYPH
cord-280878-1kt51viz	303	3	Torres	Torres	NNP
cord-280878-1kt51viz	303	4	et	et	NNP
cord-280878-1kt51viz	303	5	al	al	NNP
cord-280878-1kt51viz	303	6	.	.	NNP
cord-280878-1kt51viz	303	7	,	,	,
cord-280878-1kt51viz	303	8	2011	2011	CD
cord-280878-1kt51viz	303	9	)	)	-RRB-
cord-280878-1kt51viz	303	10	.	.	.
cord-280878-1kt51viz	304	1	CoV	CoV	NNP
cord-280878-1kt51viz	304	2	E	E	NNP
cord-280878-1kt51viz	304	3	proteins	protein	NNS
cord-280878-1kt51viz	304	4	have	have	VBP
cord-280878-1kt51viz	304	5	been	be	VBN
cord-280878-1kt51viz	304	6	found	find	VBN
cord-280878-1kt51viz	304	7	to	to	TO
cord-280878-1kt51viz	304	8	be	be	VB
cord-280878-1kt51viz	304	9	critical	critical	JJ
cord-280878-1kt51viz	304	10	for	for	IN
cord-280878-1kt51viz	304	11	viral	viral	JJ
cord-280878-1kt51viz	304	12	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	304	13	,	,	,
cord-280878-1kt51viz	304	14	while	while	IN
cord-280878-1kt51viz	304	15	having	have	VBG
cord-280878-1kt51viz	304	16	a	a	DT
cord-280878-1kt51viz	304	17	protective	protective	JJ
cord-280878-1kt51viz	304	18	antiapoptotic	antiapoptotic	JJ
cord-280878-1kt51viz	304	19	effect	effect	NN
cord-280878-1kt51viz	304	20	on	on	IN
cord-280878-1kt51viz	304	21	infected	infected	JJ
cord-280878-1kt51viz	304	22	cells	cell	NNS
cord-280878-1kt51viz	304	23	which	which	WDT
cord-280878-1kt51viz	304	24	may	may	MD
cord-280878-1kt51viz	304	25	help	help	VB
cord-280878-1kt51viz	304	26	the	the	DT
cord-280878-1kt51viz	304	27	virus	virus	NN
cord-280878-1kt51viz	304	28	evade	evade	VB
cord-280878-1kt51viz	304	29	premature	premature	JJ
cord-280878-1kt51viz	304	30	death	death	NN
cord-280878-1kt51viz	304	31	of	of	IN
cord-280878-1kt51viz	304	32	host	host	NN
cord-280878-1kt51viz	304	33	cells	cell	NNS
cord-280878-1kt51viz	304	34	,	,	,
cord-280878-1kt51viz	304	35	thereby	thereby	RB
cord-280878-1kt51viz	304	36	allowing	allow	VBG
cord-280878-1kt51viz	304	37	viral	viral	JJ
cord-280878-1kt51viz	304	38	replication	replication	NN
cord-280878-1kt51viz	304	39	.	.	.
cord-280878-1kt51viz	305	1	Interestingly	interestingly	RB
cord-280878-1kt51viz	305	2	,	,	,
cord-280878-1kt51viz	305	3	deletion	deletion	NN
cord-280878-1kt51viz	305	4	of	of	IN
cord-280878-1kt51viz	305	5	E	e	NN
cord-280878-1kt51viz	305	6	protein	protein	NN
cord-280878-1kt51viz	305	7	reduced	reduce	VBN
cord-280878-1kt51viz	305	8	pathogenicity	pathogenicity	NN
cord-280878-1kt51viz	305	9	and	and	CC
cord-280878-1kt51viz	305	10	mortality	mortality	NN
cord-280878-1kt51viz	305	11	in	in	IN
cord-280878-1kt51viz	305	12	animal	animal	NN
cord-280878-1kt51viz	305	13	models	model	NNS
cord-280878-1kt51viz	305	14	through	through	IN
cord-280878-1kt51viz	305	15	a	a	DT
cord-280878-1kt51viz	305	16	reduced	reduce	VBN
cord-280878-1kt51viz	305	17	inflammation	inflammation	NN
cord-280878-1kt51viz	305	18	(	(	-LRB-
cord-280878-1kt51viz	305	19	DeDiego	DeDiego	NNP
cord-280878-1kt51viz	305	20	et	et	NNP
cord-280878-1kt51viz	305	21	al	al	NNP
cord-280878-1kt51viz	305	22	.	.	NNP
cord-280878-1kt51viz	305	23	,	,	,
cord-280878-1kt51viz	305	24	2014)-as	2014)-as	CD
cord-280878-1kt51viz	305	25	discussed	discuss	VBN
cord-280878-1kt51viz	305	26	later	later	RB
cord-280878-1kt51viz	305	27	-	-	:
cord-280878-1kt51viz	305	28	and	and	CC
cord-280878-1kt51viz	305	29	this	this	DT
cord-280878-1kt51viz	305	30	has	have	VBZ
cord-280878-1kt51viz	305	31	led	lead	VBN
cord-280878-1kt51viz	305	32	to	to	IN
cord-280878-1kt51viz	305	33	the	the	DT
cord-280878-1kt51viz	305	34	development	development	NN
cord-280878-1kt51viz	305	35	of	of	IN
cord-280878-1kt51viz	305	36	live	live	JJ
cord-280878-1kt51viz	305	37	attenuated	attenuated	JJ
cord-280878-1kt51viz	305	38	vaccines	vaccine	NNS
cord-280878-1kt51viz	305	39	based	base	VBN
cord-280878-1kt51viz	305	40	on	on	IN
cord-280878-1kt51viz	305	41	E	e	NN
cord-280878-1kt51viz	305	42	-	-	VBN
cord-280878-1kt51viz	305	43	deleted	delete	VBN
cord-280878-1kt51viz	305	44	or	or	CC
cord-280878-1kt51viz	305	45	E	e	JJ
cord-280878-1kt51viz	305	46	-	-	JJ
cord-280878-1kt51viz	305	47	truncated	truncated	JJ
cord-280878-1kt51viz	305	48	virions	virion	NNS
cord-280878-1kt51viz	305	49	(	(	-LRB-
cord-280878-1kt51viz	305	50	Almazán	Almazán	NNP
cord-280878-1kt51viz	305	51	et	et	FW
cord-280878-1kt51viz	305	52	al	al	NNP
cord-280878-1kt51viz	305	53	.	.	NNP
cord-280878-1kt51viz	305	54	,	,	,
cord-280878-1kt51viz	305	55	2013	2013	CD
cord-280878-1kt51viz	305	56	;	;	:
cord-280878-1kt51viz	306	1	Lamirande	Lamirande	NNP
cord-280878-1kt51viz	306	2	et	et	NNP
cord-280878-1kt51viz	306	3	al	al	NNP
cord-280878-1kt51viz	306	4	.	.	NNP
cord-280878-1kt51viz	306	5	,	,	,
cord-280878-1kt51viz	306	6	2008	2008	CD
cord-280878-1kt51viz	306	7	;	;	:
cord-280878-1kt51viz	306	8	Netland	Netland	NNP
cord-280878-1kt51viz	306	9	et	et	NNP
cord-280878-1kt51viz	306	10	al	al	NNP
cord-280878-1kt51viz	306	11	.	.	NNP
cord-280878-1kt51viz	306	12	,	,	,
cord-280878-1kt51viz	306	13	2010	2010	CD
cord-280878-1kt51viz	306	14	)	)	-RRB-
cord-280878-1kt51viz	306	15	.	.	.
cord-280878-1kt51viz	307	1	The	the	DT
cord-280878-1kt51viz	307	2	only	only	JJ
cord-280878-1kt51viz	307	3	structural	structural	JJ
cord-280878-1kt51viz	307	4	data	datum	NNS
cord-280878-1kt51viz	307	5	available	available	JJ
cord-280878-1kt51viz	307	6	for	for	IN
cord-280878-1kt51viz	307	7	a	a	DT
cord-280878-1kt51viz	307	8	CoV	cov	NN
cord-280878-1kt51viz	307	9	E	e	NN
cord-280878-1kt51viz	307	10	protein	protein	NN
cord-280878-1kt51viz	307	11	is	be	VBZ
cord-280878-1kt51viz	307	12	for	for	IN
cord-280878-1kt51viz	307	13	SARS	SARS	NNP
cord-280878-1kt51viz	307	14	-	-	HYPH
cord-280878-1kt51viz	307	15	CoV	CoV	NNP
cord-280878-1kt51viz	307	16	E	E	NNP
cord-280878-1kt51viz	307	17	,	,	,
cord-280878-1kt51viz	307	18	where	where	WRB
cord-280878-1kt51viz	307	19	the	the	DT
cord-280878-1kt51viz	307	20	TM	TM	NNP
cord-280878-1kt51viz	307	21	domain	domain	NN
cord-280878-1kt51viz	307	22	(	(	-LRB-
cord-280878-1kt51viz	307	23	E	E	NNP
cord-280878-1kt51viz	307	24	-	-	NN
cord-280878-1kt51viz	307	25	TM	TM	NNP
cord-280878-1kt51viz	307	26	)	)	-RRB-
cord-280878-1kt51viz	307	27	has	have	VBZ
cord-280878-1kt51viz	307	28	been	be	VBN
cord-280878-1kt51viz	307	29	characterized	characterize	VBN
cord-280878-1kt51viz	307	30	in	in	IN
cord-280878-1kt51viz	307	31	some	some	DT
cord-280878-1kt51viz	307	32	detail	detail	NN
cord-280878-1kt51viz	307	33	in	in	IN
cord-280878-1kt51viz	307	34	lipid	lipid	NN
cord-280878-1kt51viz	307	35	membranes	membrane	NNS
cord-280878-1kt51viz	307	36	.	.	.
cord-280878-1kt51viz	308	1	Later	later	RB
cord-280878-1kt51viz	308	2	,	,	,
cord-280878-1kt51viz	308	3	solution	solution	NN
cord-280878-1kt51viz	308	4	NMR	nmr	NN
cord-280878-1kt51viz	308	5	of	of	IN
cord-280878-1kt51viz	308	6	the	the	DT
cord-280878-1kt51viz	308	7	selectively	selectively	RB
cord-280878-1kt51viz	308	8	labelled	label	VBN
cord-280878-1kt51viz	308	9	synthetic	synthetic	JJ
cord-280878-1kt51viz	308	10	E	e	NN
cord-280878-1kt51viz	308	11	-	-	NN
cord-280878-1kt51viz	308	12	TM	TM	NNP
cord-280878-1kt51viz	308	13	(	(	-LRB-
cord-280878-1kt51viz	308	14	residues	residue	NNS
cord-280878-1kt51viz	308	15	8	8	CD
cord-280878-1kt51viz	308	16	-	-	SYM
cord-280878-1kt51viz	308	17	38	38	CD
cord-280878-1kt51viz	308	18	)	)	-RRB-
cord-280878-1kt51viz	308	19	in	in	IN
cord-280878-1kt51viz	308	20	DPC	DPC	NNP
cord-280878-1kt51viz	308	21	micelles	micelle	NNS
cord-280878-1kt51viz	308	22	produced	produce	VBD
cord-280878-1kt51viz	308	23	a	a	DT
cord-280878-1kt51viz	308	24	similar	similar	JJ
cord-280878-1kt51viz	308	25	pentameric	pentameric	NN
cord-280878-1kt51viz	308	26	left	leave	VBN
cord-280878-1kt51viz	308	27	-	-	HYPH
cord-280878-1kt51viz	308	28	handed	handed	JJ
cord-280878-1kt51viz	308	29	parallel	parallel	JJ
cord-280878-1kt51viz	308	30	bundle	bundle	NN
cord-280878-1kt51viz	308	31	(	(	-LRB-
cord-280878-1kt51viz	308	32	Pervushin	Pervushin	NNP
cord-280878-1kt51viz	308	33	et	et	FW
cord-280878-1kt51viz	308	34	al	al	NNP
cord-280878-1kt51viz	308	35	.	.	NNP
cord-280878-1kt51viz	308	36	,	,	,
cord-280878-1kt51viz	308	37	2009	2009	CD
cord-280878-1kt51viz	308	38	)	)	-RRB-
cord-280878-1kt51viz	308	39	.	.	.
cord-280878-1kt51viz	309	1	In	in	IN
cord-280878-1kt51viz	309	2	these	these	DT
cord-280878-1kt51viz	309	3	models	model	NNS
cord-280878-1kt51viz	309	4	,	,	,
cord-280878-1kt51viz	309	5	Asn-15	Asn-15	NNP
cord-280878-1kt51viz	309	6	is	be	VBZ
cord-280878-1kt51viz	309	7	facing	face	VBG
cord-280878-1kt51viz	309	8	the	the	DT
cord-280878-1kt51viz	309	9	lumen	lumen	NN
cord-280878-1kt51viz	309	10	of	of	IN
cord-280878-1kt51viz	309	11	the	the	DT
cord-280878-1kt51viz	309	12	channel	channel	NN
cord-280878-1kt51viz	309	13	whereas	whereas	IN
cord-280878-1kt51viz	309	14	Val-25	Val-25	NNP
cord-280878-1kt51viz	309	15	is	be	VBZ
cord-280878-1kt51viz	309	16	involved	involve	VBN
cord-280878-1kt51viz	309	17	in	in	IN
cord-280878-1kt51viz	309	18	helix	helix	NN
cord-280878-1kt51viz	309	19	-	-	HYPH
cord-280878-1kt51viz	309	20	helix	helix	NN
cord-280878-1kt51viz	309	21	interactions	interaction	NNS
cord-280878-1kt51viz	309	22	with	with	IN
cord-280878-1kt51viz	309	23	other	other	JJ
cord-280878-1kt51viz	309	24	subunits	subunit	NNS
cord-280878-1kt51viz	309	25	(	(	-LRB-
cord-280878-1kt51viz	309	26	Pervushin	Pervushin	NNP
cord-280878-1kt51viz	309	27	et	et	FW
cord-280878-1kt51viz	309	28	al	al	NNP
cord-280878-1kt51viz	309	29	.	.	NNP
cord-280878-1kt51viz	309	30	,	,	,
cord-280878-1kt51viz	309	31	2009	2009	CD
cord-280878-1kt51viz	309	32	)	)	-RRB-
cord-280878-1kt51viz	309	33	.	.	.
cord-280878-1kt51viz	310	1	Mutations	mutation	NNS
cord-280878-1kt51viz	310	2	at	at	IN
cord-280878-1kt51viz	310	3	these	these	DT
cord-280878-1kt51viz	310	4	residues	residue	NNS
cord-280878-1kt51viz	310	5	,	,	,
cord-280878-1kt51viz	310	6	N15A	n15a	NN
cord-280878-1kt51viz	310	7	and	and	CC
cord-280878-1kt51viz	310	8	V25F	V25F	NNP
cord-280878-1kt51viz	310	9	,	,	,
cord-280878-1kt51viz	310	10	abolished	abolish	VBN
cord-280878-1kt51viz	310	11	channel	channel	NN
cord-280878-1kt51viz	310	12	activity	activity	NN
cord-280878-1kt51viz	310	13	in	in	IN
cord-280878-1kt51viz	310	14	vitro	vitro	FW
cord-280878-1kt51viz	311	1	(	(	-LRB-
cord-280878-1kt51viz	311	2	Torres	Torres	NNP
cord-280878-1kt51viz	311	3	et	et	NNP
cord-280878-1kt51viz	311	4	al	al	NNP
cord-280878-1kt51viz	311	5	.	.	NNP
cord-280878-1kt51viz	311	6	,	,	,
cord-280878-1kt51viz	311	7	2007	2007	CD
cord-280878-1kt51viz	311	8	)	)	-RRB-
cord-280878-1kt51viz	311	9	,	,	,
cord-280878-1kt51viz	311	10	and	and	CC
cord-280878-1kt51viz	311	11	introduction	introduction	NN
cord-280878-1kt51viz	311	12	of	of	IN
cord-280878-1kt51viz	311	13	these	these	DT
cord-280878-1kt51viz	311	14	mutations	mutation	NNS
cord-280878-1kt51viz	311	15	in	in	IN
cord-280878-1kt51viz	311	16	a	a	DT
cord-280878-1kt51viz	311	17	recombinant	recombinant	JJ
cord-280878-1kt51viz	311	18	SARS	SARS	NNP
cord-280878-1kt51viz	311	19	-	-	HYPH
cord-280878-1kt51viz	311	20	CoV	CoV	NNP
cord-280878-1kt51viz	311	21	resulted	result	VBD
cord-280878-1kt51viz	311	22	in	in	IN
cord-280878-1kt51viz	311	23	in	in	IN
cord-280878-1kt51viz	311	24	vivo	vivo	NN
cord-280878-1kt51viz	311	25	attenuation	attenuation	NN
cord-280878-1kt51viz	311	26	in	in	IN
cord-280878-1kt51viz	311	27	a	a	DT
cord-280878-1kt51viz	311	28	mouse	mouse	NN
cord-280878-1kt51viz	311	29	model	model	NN
cord-280878-1kt51viz	311	30	.	.	.
cord-280878-1kt51viz	312	1	The	the	DT
cord-280878-1kt51viz	312	2	integrity	integrity	NN
cord-280878-1kt51viz	312	3	of	of	IN
cord-280878-1kt51viz	312	4	the	the	DT
cord-280878-1kt51viz	312	5	TM	TM	NNP
cord-280878-1kt51viz	312	6	domain	domain	NN
cord-280878-1kt51viz	312	7	,	,	,
cord-280878-1kt51viz	312	8	and	and	CC
cord-280878-1kt51viz	312	9	preservation	preservation	NN
cord-280878-1kt51viz	312	10	of	of	IN
cord-280878-1kt51viz	312	11	channel	channel	NN
cord-280878-1kt51viz	312	12	activity	activity	NN
cord-280878-1kt51viz	312	13	,	,	,
cord-280878-1kt51viz	312	14	were	be	VBD
cord-280878-1kt51viz	312	15	shown	show	VBN
cord-280878-1kt51viz	312	16	to	to	TO
cord-280878-1kt51viz	312	17	be	be	VB
cord-280878-1kt51viz	312	18	important	important	JJ
cord-280878-1kt51viz	312	19	for	for	IN
cord-280878-1kt51viz	312	20	inflammasome	inflammasome	NN
cord-280878-1kt51viz	312	21	activation	activation	NN
cord-280878-1kt51viz	312	22	and	and	CC
cord-280878-1kt51viz	312	23	elevated	elevated	JJ
cord-280878-1kt51viz	312	24	production	production	NN
cord-280878-1kt51viz	312	25	of	of	IN
cord-280878-1kt51viz	312	26	the	the	DT
cord-280878-1kt51viz	312	27	proinflammatory	proinflammatory	JJ
cord-280878-1kt51viz	312	28	cytokine	cytokine	NN
cord-280878-1kt51viz	312	29	IL-1β	il-1β	NN
cord-280878-1kt51viz	312	30	(	(	-LRB-
cord-280878-1kt51viz	312	31	Nieto-	Nieto-	NNP
cord-280878-1kt51viz	312	32	.	.	.
cord-280878-1kt51viz	313	1	In	in	IN
cord-280878-1kt51viz	313	2	the	the	DT
cord-280878-1kt51viz	313	3	same	same	JJ
cord-280878-1kt51viz	313	4	study	study	NN
cord-280878-1kt51viz	313	5	,	,	,
cord-280878-1kt51viz	313	6	revertant	revertant	NN
cord-280878-1kt51viz	313	7	mutants	mutant	NNS
cord-280878-1kt51viz	313	8	of	of	IN
cord-280878-1kt51viz	313	9	the	the	DT
cord-280878-1kt51viz	313	10	channel	channel	NN
cord-280878-1kt51viz	313	11	-	-	HYPH
cord-280878-1kt51viz	313	12	inactive	inactive	JJ
cord-280878-1kt51viz	313	13	E	E	NNP
cord-280878-1kt51viz	313	14	that	that	WDT
cord-280878-1kt51viz	313	15	regained	regain	VBD
cord-280878-1kt51viz	313	16	fitness	fitness	NN
cord-280878-1kt51viz	313	17	and	and	CC
cord-280878-1kt51viz	313	18	pathogenicity	pathogenicity	NN
cord-280878-1kt51viz	313	19	also	also	RB
cord-280878-1kt51viz	313	20	regained	regain	VBD
cord-280878-1kt51viz	313	21	channel	channel	NN
cord-280878-1kt51viz	313	22	activity	activity	NN
cord-280878-1kt51viz	313	23	,	,	,
cord-280878-1kt51viz	313	24	as	as	IN
cord-280878-1kt51viz	313	25	measured	measure	VBN
cord-280878-1kt51viz	313	26	in	in	IN
cord-280878-1kt51viz	313	27	black	black	JJ
cord-280878-1kt51viz	313	28	lipid	lipid	NN
cord-280878-1kt51viz	313	29	membranes	membrane	NNS
cord-280878-1kt51viz	313	30	.	.	.
cord-280878-1kt51viz	314	1	Both	both	DT
cord-280878-1kt51viz	314	2	E	E	NNP
cord-280878-1kt51viz	314	3	-	-	NN
cord-280878-1kt51viz	314	4	TM	TM	NNP
cord-280878-1kt51viz	314	5	and	and	CC
cord-280878-1kt51viz	314	6	the	the	DT
cord-280878-1kt51viz	314	7	full	full	JJ
cord-280878-1kt51viz	314	8	-	-	HYPH
cord-280878-1kt51viz	314	9	length	length	NN
cord-280878-1kt51viz	314	10	E	e	NN
cord-280878-1kt51viz	314	11	protein	protein	NN
cord-280878-1kt51viz	314	12	form	form	NN
cord-280878-1kt51viz	314	13	homopentameric	homopentameric	JJ
cord-280878-1kt51viz	314	14	channels	channel	NNS
cord-280878-1kt51viz	314	15	with	with	IN
cord-280878-1kt51viz	314	16	poor	poor	JJ
cord-280878-1kt51viz	314	17	ion	ion	NN
cord-280878-1kt51viz	314	18	selectivity	selectivity	NN
cord-280878-1kt51viz	314	19	that	that	WDT
cord-280878-1kt51viz	314	20	can	can	MD
cord-280878-1kt51viz	314	21	be	be	VB
cord-280878-1kt51viz	314	22	partially	partially	RB
cord-280878-1kt51viz	314	23	inhibited	inhibit	VBN
cord-280878-1kt51viz	314	24	by	by	IN
cord-280878-1kt51viz	314	25	the	the	DT
cord-280878-1kt51viz	314	26	drug	drug	NN
cord-280878-1kt51viz	314	27	HMA	HMA	NNP
cord-280878-1kt51viz	314	28	with	with	IN
cord-280878-1kt51viz	314	29	micromolar	micromolar	JJ
cord-280878-1kt51viz	314	30	affinity	affinity	NN
cord-280878-1kt51viz	314	31	(	(	-LRB-
cord-280878-1kt51viz	314	32	Verdia	Verdia	NNP
cord-280878-1kt51viz	314	33	-	-	HYPH
cord-280878-1kt51viz	314	34	Baguena	Baguena	NNP
cord-280878-1kt51viz	314	35	et	et	FW
cord-280878-1kt51viz	314	36	al	al	NNP
cord-280878-1kt51viz	314	37	.	.	NNP
cord-280878-1kt51viz	314	38	,	,	,
cord-280878-1kt51viz	314	39	2012	2012	CD
cord-280878-1kt51viz	314	40	;	;	:
cord-280878-1kt51viz	314	41	Wilson	Wilson	NNP
cord-280878-1kt51viz	314	42	,	,	,
cord-280878-1kt51viz	314	43	Gage	Gage	NNP
cord-280878-1kt51viz	314	44	,	,	,
cord-280878-1kt51viz	314	45	&	&	CC
cord-280878-1kt51viz	314	46	Ewart	Ewart	NNP
cord-280878-1kt51viz	314	47	,	,	,
cord-280878-1kt51viz	314	48	2006	2006	CD
cord-280878-1kt51viz	314	49	)	)	-RRB-
cord-280878-1kt51viz	314	50	.	.	.
cord-280878-1kt51viz	315	1	The	the	DT
cord-280878-1kt51viz	315	2	NOEs	no	NNS
cord-280878-1kt51viz	315	3	between	between	IN
cord-280878-1kt51viz	315	4	HMA	HMA	NNP
cord-280878-1kt51viz	315	5	and	and	CC
cord-280878-1kt51viz	315	6	E	E	NNP
cord-280878-1kt51viz	315	7	-	-	NN
cord-280878-1kt51viz	315	8	TM	TM	NNP
cord-280878-1kt51viz	315	9	suggested	suggest	VBD
cord-280878-1kt51viz	315	10	the	the	DT
cord-280878-1kt51viz	315	11	presence	presence	NN
cord-280878-1kt51viz	315	12	of	of	IN
cord-280878-1kt51viz	315	13	two	two	CD
cord-280878-1kt51viz	315	14	binding	bind	VBG
cord-280878-1kt51viz	315	15	sites	site	NNS
cord-280878-1kt51viz	315	16	at	at	IN
cord-280878-1kt51viz	315	17	both	both	DT
cord-280878-1kt51viz	315	18	ends	end	NNS
cord-280878-1kt51viz	315	19	of	of	IN
cord-280878-1kt51viz	315	20	the	the	DT
cord-280878-1kt51viz	315	21	TM	TM	NNP
cord-280878-1kt51viz	315	22	domain	domain	NN
cord-280878-1kt51viz	315	23	.	.	.
cord-280878-1kt51viz	316	1	At	at	IN
cord-280878-1kt51viz	316	2	the	the	DT
cord-280878-1kt51viz	316	3	N	n	CD
cord-280878-1kt51viz	316	4	-	-	HYPH
cord-280878-1kt51viz	316	5	terminal	terminal	NN
cord-280878-1kt51viz	316	6	domain	domain	NN
cord-280878-1kt51viz	316	7	,	,	,
cord-280878-1kt51viz	316	8	Leu-19	Leu-19	NNP
cord-280878-1kt51viz	316	9	exhibited	exhibit	VBD
cord-280878-1kt51viz	316	10	the	the	DT
cord-280878-1kt51viz	316	11	largest	large	JJS
cord-280878-1kt51viz	316	12	chemical	chemical	JJ
cord-280878-1kt51viz	316	13	shift	shift	NN
cord-280878-1kt51viz	316	14	,	,	,
cord-280878-1kt51viz	316	15	and	and	CC
cord-280878-1kt51viz	316	16	the	the	DT
cord-280878-1kt51viz	316	17	relative	relative	JJ
cord-280878-1kt51viz	316	18	intensities	intensity	NNS
cord-280878-1kt51viz	316	19	of	of	IN
cord-280878-1kt51viz	316	20	the	the	DT
cord-280878-1kt51viz	316	21	HMA	HMA	NNP
cord-280878-1kt51viz	316	22	proton	proton	NN
cord-280878-1kt51viz	316	23	cross	cross	NN
cord-280878-1kt51viz	316	24	-	-	NNS
cord-280878-1kt51viz	316	25	peaks	peak	NNS
cord-280878-1kt51viz	316	26	indicated	indicate	VBD
cord-280878-1kt51viz	316	27	an	an	DT
cord-280878-1kt51viz	316	28	HMA	HMA	NNP
cord-280878-1kt51viz	316	29	:	:	:
cord-280878-1kt51viz	316	30	E	E	NNP
cord-280878-1kt51viz	316	31	-	-	NN
cord-280878-1kt51viz	316	32	TM	TM	NNP
cord-280878-1kt51viz	316	33	stoichiometry	stoichiometry	NN
cord-280878-1kt51viz	316	34	of	of	IN
cord-280878-1kt51viz	316	35	1:5	1:5	CD
cord-280878-1kt51viz	316	36	at	at	IN
cord-280878-1kt51viz	316	37	the	the	DT
cord-280878-1kt51viz	316	38	N	n	CD
cord-280878-1kt51viz	316	39	-	-	HYPH
cord-280878-1kt51viz	316	40	terminal	terminal	NN
cord-280878-1kt51viz	316	41	binding	binding	NN
cord-280878-1kt51viz	316	42	site	site	NN
cord-280878-1kt51viz	316	43	near	near	IN
cord-280878-1kt51viz	316	44	Asn-15	Asn-15	NNP
cord-280878-1kt51viz	316	45	,	,	,
cord-280878-1kt51viz	316	46	suggesting	suggest	VBG
cord-280878-1kt51viz	316	47	one	one	CD
cord-280878-1kt51viz	316	48	HMA	HMA	NNP
cord-280878-1kt51viz	316	49	molecule	molecule	NN
cord-280878-1kt51viz	316	50	per	per	IN
cord-280878-1kt51viz	316	51	E	E	NNP
cord-280878-1kt51viz	316	52	-	-	NN
cord-280878-1kt51viz	316	53	TM	TM	NNP
cord-280878-1kt51viz	316	54	pentamer	pentamer	NNP
cord-280878-1kt51viz	316	55	.	.	.
cord-280878-1kt51viz	317	1	This	this	DT
cord-280878-1kt51viz	317	2	is	be	VBZ
cord-280878-1kt51viz	317	3	consistent	consistent	JJ
cord-280878-1kt51viz	317	4	with	with	IN
cord-280878-1kt51viz	317	5	a	a	DT
cord-280878-1kt51viz	317	6	pore	pore	NN
cord-280878-1kt51viz	317	7	-	-	HYPH
cord-280878-1kt51viz	317	8	blocking	block	VBG
cord-280878-1kt51viz	317	9	inhibition	inhibition	NN
cord-280878-1kt51viz	317	10	mode	mode	NN
cord-280878-1kt51viz	317	11	similar	similar	JJ
cord-280878-1kt51viz	317	12	to	to	IN
cord-280878-1kt51viz	317	13	Amt	Amt	NNP
cord-280878-1kt51viz	317	14	in	in	IN
cord-280878-1kt51viz	317	15	AM2	AM2	NNP
cord-280878-1kt51viz	317	16	,	,	,
cord-280878-1kt51viz	317	17	where	where	WRB
cord-280878-1kt51viz	317	18	in	in	IN
cord-280878-1kt51viz	317	19	this	this	DT
cord-280878-1kt51viz	317	20	case	case	NN
cord-280878-1kt51viz	317	21	the	the	DT
cord-280878-1kt51viz	317	22	HMA	HMA	NNP
cord-280878-1kt51viz	317	23	molecule	molecule	NN
cord-280878-1kt51viz	317	24	may	may	MD
cord-280878-1kt51viz	317	25	be	be	VB
cord-280878-1kt51viz	317	26	stabilized	stabilize	VBN
cord-280878-1kt51viz	317	27	by	by	IN
cord-280878-1kt51viz	317	28	a	a	DT
cord-280878-1kt51viz	317	29	hydrogen	hydrogen	NN
cord-280878-1kt51viz	317	30	bonding	bonding	NN
cord-280878-1kt51viz	317	31	network	network	NN
cord-280878-1kt51viz	317	32	to	to	IN
cord-280878-1kt51viz	317	33	the	the	DT
cord-280878-1kt51viz	317	34	Asn-15	Asn-15	NNP
cord-280878-1kt51viz	317	35	side	side	NN
cord-280878-1kt51viz	317	36	chains	chain	NNS
cord-280878-1kt51viz	317	37	of	of	IN
cord-280878-1kt51viz	317	38	the	the	DT
cord-280878-1kt51viz	317	39	SARS	SARS	NNP
cord-280878-1kt51viz	317	40	-	-	HYPH
cord-280878-1kt51viz	317	41	CoV	CoV	NNP
cord-280878-1kt51viz	317	42	E	E	NNP
cord-280878-1kt51viz	317	43	,	,	,
cord-280878-1kt51viz	317	44	with	with	IN
cord-280878-1kt51viz	317	45	the	the	DT
cord-280878-1kt51viz	317	46	cyclohexamethylene	cyclohexamethylene	NN
cord-280878-1kt51viz	317	47	ring	ring	NN
cord-280878-1kt51viz	317	48	pointing	point	VBG
cord-280878-1kt51viz	317	49	away	away	RB
cord-280878-1kt51viz	317	50	from	from	IN
cord-280878-1kt51viz	317	51	the	the	DT
cord-280878-1kt51viz	317	52	center	center	NN
cord-280878-1kt51viz	317	53	of	of	IN
cord-280878-1kt51viz	317	54	the	the	DT
cord-280878-1kt51viz	317	55	channel	channel	NN
cord-280878-1kt51viz	318	1	(	(	-LRB-
cord-280878-1kt51viz	318	2	Fig	Fig	NNP
cord-280878-1kt51viz	318	3	.	.	.
cord-280878-1kt51viz	318	4	6A	6a	CD
cord-280878-1kt51viz	318	5	)	)	-RRB-
cord-280878-1kt51viz	318	6	.	.	.
cord-280878-1kt51viz	319	1	At	at	IN
cord-280878-1kt51viz	319	2	the	the	DT
cord-280878-1kt51viz	319	3	C	c	NN
cord-280878-1kt51viz	319	4	-	-	HYPH
cord-280878-1kt51viz	319	5	terminal	terminal	NN
cord-280878-1kt51viz	319	6	of	of	IN
cord-280878-1kt51viz	319	7	the	the	DT
cord-280878-1kt51viz	319	8	TM	TM	NNP
cord-280878-1kt51viz	319	9	domain	domain	NN
cord-280878-1kt51viz	319	10	,	,	,
cord-280878-1kt51viz	319	11	near	near	IN
cord-280878-1kt51viz	319	12	Arg-38	Arg-38	NNP
cord-280878-1kt51viz	319	13	,	,	,
cord-280878-1kt51viz	319	14	the	the	DT
cord-280878-1kt51viz	319	15	HMA	HMA	NNP
cord-280878-1kt51viz	319	16	:	:	:
cord-280878-1kt51viz	319	17	E	E	NNP
cord-280878-1kt51viz	319	18	-	-	NN
cord-280878-1kt51viz	319	19	TM	TM	NNP
cord-280878-1kt51viz	319	20	stoichiometry	stoichiometry	NN
cord-280878-1kt51viz	319	21	was	be	VBD
cord-280878-1kt51viz	319	22	1:2	1:2	CD
cord-280878-1kt51viz	319	23	,	,	,
cord-280878-1kt51viz	319	24	suggesting	suggest	VBG
cord-280878-1kt51viz	319	25	for	for	IN
cord-280878-1kt51viz	319	26	this	this	DT
cord-280878-1kt51viz	319	27	site	site	NN
cord-280878-1kt51viz	319	28	a	a	DT
cord-280878-1kt51viz	319	29	rapid	rapid	JJ
cord-280878-1kt51viz	319	30	exchange	exchange	NN
cord-280878-1kt51viz	319	31	,	,	,
cord-280878-1kt51viz	319	32	in	in	IN
cord-280878-1kt51viz	319	33	the	the	DT
cord-280878-1kt51viz	319	34	chemical	chemical	JJ
cord-280878-1kt51viz	319	35	shift	shift	NN
cord-280878-1kt51viz	319	36	timescale	timescale	NN
cord-280878-1kt51viz	319	37	,	,	,
cord-280878-1kt51viz	319	38	between	between	IN
cord-280878-1kt51viz	319	39	E	E	NNP
cord-280878-1kt51viz	319	40	-	-	NN
cord-280878-1kt51viz	319	41	TM	tm	NN
cord-280878-1kt51viz	319	42	-	-	HYPH
cord-280878-1kt51viz	319	43	bound	bind	VBN
cord-280878-1kt51viz	319	44	and	and	CC
cord-280878-1kt51viz	319	45	micelle	micelle	NN
cord-280878-1kt51viz	319	46	-	-	HYPH
cord-280878-1kt51viz	319	47	bound	bind	VBN
cord-280878-1kt51viz	319	48	forms	form	NNS
cord-280878-1kt51viz	319	49	of	of	IN
cord-280878-1kt51viz	319	50	HMA	HMA	NNP
cord-280878-1kt51viz	319	51	.	.	.
cord-280878-1kt51viz	320	1	At	at	IN
cord-280878-1kt51viz	320	2	this	this	DT
cord-280878-1kt51viz	320	3	location	location	NN
cord-280878-1kt51viz	320	4	,	,	,
cord-280878-1kt51viz	320	5	the	the	DT
cord-280878-1kt51viz	320	6	amiloride	amiloride	NNP
cord-280878-1kt51viz	320	7	group	group	NN
cord-280878-1kt51viz	320	8	of	of	IN
cord-280878-1kt51viz	320	9	HMA	HMA	NNP
cord-280878-1kt51viz	320	10	is	be	VBZ
cord-280878-1kt51viz	320	11	likely	likely	JJ
cord-280878-1kt51viz	320	12	to	to	TO
cord-280878-1kt51viz	320	13	be	be	VB
cord-280878-1kt51viz	320	14	involved	involve	VBN
cord-280878-1kt51viz	320	15	in	in	IN
cord-280878-1kt51viz	320	16	interactions	interaction	NNS
cord-280878-1kt51viz	320	17	with	with	IN
cord-280878-1kt51viz	320	18	the	the	DT
cord-280878-1kt51viz	320	19	guanidinium	guanidinium	NN
cord-280878-1kt51viz	320	20	groups	group	NNS
cord-280878-1kt51viz	320	21	of	of	IN
cord-280878-1kt51viz	320	22	Arg-38	Arg-38	NNP
cord-280878-1kt51viz	320	23	(	(	-LRB-
cord-280878-1kt51viz	320	24	Fig	Fig	NNP
cord-280878-1kt51viz	320	25	.	.	.
cord-280878-1kt51viz	320	26	6B	6b	CD
cord-280878-1kt51viz	320	27	)	)	-RRB-
cord-280878-1kt51viz	320	28	.	.	.
cord-280878-1kt51viz	321	1	These	these	DT
cord-280878-1kt51viz	321	2	results	result	NNS
cord-280878-1kt51viz	321	3	were	be	VBD
cord-280878-1kt51viz	321	4	confirmed	confirm	VBN
cord-280878-1kt51viz	321	5	using	use	VBG
cord-280878-1kt51viz	321	6	the	the	DT
cord-280878-1kt51viz	321	7	extended	extended	JJ
cord-280878-1kt51viz	321	8	peptide	peptide	NN
cord-280878-1kt51viz	321	9	E	e	NN
cord-280878-1kt51viz	321	10	(	(	-LRB-
cord-280878-1kt51viz	321	11	8	8	CD
cord-280878-1kt51viz	321	12	-	-	SYM
cord-280878-1kt51viz	321	13	65	65	CD
cord-280878-1kt51viz	321	14	)	)	-RRB-
cord-280878-1kt51viz	321	15	in	in	IN
cord-280878-1kt51viz	321	16	mixed	mixed	JJ
cord-280878-1kt51viz	321	17	SDS	SDS	NNP
cord-280878-1kt51viz	321	18	/	/	SYM
cord-280878-1kt51viz	321	19	DPC	DPC	NNP
cord-280878-1kt51viz	321	20	(	(	-LRB-
cord-280878-1kt51viz	321	21	1:4	1:4	CD
cord-280878-1kt51viz	321	22	molar	molar	JJ
cord-280878-1kt51viz	321	23	ratio	ratio	NN
cord-280878-1kt51viz	321	24	)	)	-RRB-
cord-280878-1kt51viz	321	25	micelles	micelle	NNS
cord-280878-1kt51viz	321	26	,	,	,
cord-280878-1kt51viz	321	27	where	where	WRB
cord-280878-1kt51viz	321	28	the	the	DT
cord-280878-1kt51viz	321	29	addition	addition	NN
cord-280878-1kt51viz	321	30	of	of	IN
cord-280878-1kt51viz	321	31	HMA	HMA	NNP
cord-280878-1kt51viz	321	32	perturbed	perturb	VBD
cord-280878-1kt51viz	321	33	residues	residue	NNS
cord-280878-1kt51viz	321	34	clustered	cluster	VBN
cord-280878-1kt51viz	321	35	near	near	IN
cord-280878-1kt51viz	321	36	the	the	DT
cord-280878-1kt51viz	321	37	N	n	CD
cord-280878-1kt51viz	321	38	-	-	HYPH
cord-280878-1kt51viz	321	39	terminal	terminal	JJ
cord-280878-1kt51viz	321	40	end	end	NN
cord-280878-1kt51viz	321	41	of	of	IN
cord-280878-1kt51viz	321	42	the	the	DT
cord-280878-1kt51viz	321	43	TM	TM	NNP
cord-280878-1kt51viz	321	44	domain	domain	NN
cord-280878-1kt51viz	321	45	,	,	,
cord-280878-1kt51viz	321	46	eg	eg	XX
cord-280878-1kt51viz	321	47	,	,	,
cord-280878-1kt51viz	321	48	.	.	.
cord-280878-1kt51viz	322	1	At	at	IN
cord-280878-1kt51viz	322	2	the	the	DT
cord-280878-1kt51viz	322	3	C	c	NN
cord-280878-1kt51viz	322	4	-	-	HYPH
cord-280878-1kt51viz	322	5	terminal	terminal	JJ
cord-280878-1kt51viz	322	6	end	end	NN
cord-280878-1kt51viz	322	7	of	of	IN
cord-280878-1kt51viz	322	8	the	the	DT
cord-280878-1kt51viz	322	9	TM	TM	NNP
cord-280878-1kt51viz	322	10	,	,	,
cord-280878-1kt51viz	322	11	Leu-37	Leu-37	NNP
cord-280878-1kt51viz	322	12	was	be	VBD
cord-280878-1kt51viz	322	13	the	the	DT
cord-280878-1kt51viz	322	14	most	most	RBS
cord-280878-1kt51viz	322	15	affected	affect	VBN
cord-280878-1kt51viz	322	16	,	,	,
cord-280878-1kt51viz	322	17	suggesting	suggest	VBG
cord-280878-1kt51viz	322	18	that	that	IN
cord-280878-1kt51viz	322	19	the	the	DT
cord-280878-1kt51viz	322	20	interaction	interaction	NN
cord-280878-1kt51viz	322	21	of	of	IN
cord-280878-1kt51viz	322	22	HMA	HMA	NNP
cord-280878-1kt51viz	322	23	at	at	IN
cord-280878-1kt51viz	322	24	the	the	DT
cord-280878-1kt51viz	322	25	Hε	Hε	NNP
cord-280878-1kt51viz	322	26	of	of	IN
cord-280878-1kt51viz	322	27	Arg-38	Arg-38	NNP
cord-280878-1kt51viz	322	28	reported	report	VBD
cord-280878-1kt51viz	322	29	previously	previously	RB
cord-280878-1kt51viz	322	30	may	may	MD
cord-280878-1kt51viz	322	31	have	have	VB
cord-280878-1kt51viz	322	32	been	be	VBN
cord-280878-1kt51viz	322	33	an	an	DT
cord-280878-1kt51viz	322	34	artifact	artifact	NN
cord-280878-1kt51viz	322	35	due	due	IN
cord-280878-1kt51viz	322	36	to	to	IN
cord-280878-1kt51viz	322	37	the	the	DT
cord-280878-1kt51viz	322	38	use	use	NN
cord-280878-1kt51viz	322	39	of	of	IN
cord-280878-1kt51viz	322	40	an	an	DT
cord-280878-1kt51viz	322	41	E	e	NN
cord-280878-1kt51viz	322	42	-	-	NN
cord-280878-1kt51viz	322	43	TM	tm	NN
cord-280878-1kt51viz	322	44	(	(	-LRB-
cord-280878-1kt51viz	322	45	8	8	CD
cord-280878-1kt51viz	322	46	-	-	SYM
cord-280878-1kt51viz	322	47	38	38	CD
cord-280878-1kt51viz	322	48	)	)	-RRB-
cord-280878-1kt51viz	322	49	peptide	peptide	NN
cord-280878-1kt51viz	322	50	.	.	.
cord-280878-1kt51viz	323	1	In	in	IN
cord-280878-1kt51viz	323	2	any	any	DT
cord-280878-1kt51viz	323	3	case	case	NN
cord-280878-1kt51viz	323	4	,	,	,
cord-280878-1kt51viz	323	5	these	these	DT
cord-280878-1kt51viz	323	6	results	result	NNS
cord-280878-1kt51viz	323	7	suggest	suggest	VBP
cord-280878-1kt51viz	323	8	a	a	DT
cord-280878-1kt51viz	323	9	similar	similar	JJ
cord-280878-1kt51viz	323	10	behaviour	behaviour	NN
cord-280878-1kt51viz	323	11	of	of	IN
cord-280878-1kt51viz	323	12	HMA	HMA	NNP
cord-280878-1kt51viz	323	13	-	-	HYPH
cord-280878-1kt51viz	323	14	to	to	IN
cord-280878-1kt51viz	323	15	-	-	HYPH
cord-280878-1kt51viz	323	16	E	e	NN
cord-280878-1kt51viz	323	17	protein	protein	NN
cord-280878-1kt51viz	323	18	and	and	CC
cord-280878-1kt51viz	323	19	Amt	Amt	NNP
cord-280878-1kt51viz	323	20	-	-	HYPH
cord-280878-1kt51viz	323	21	to	to	IN
cord-280878-1kt51viz	323	22	-	-	HYPH
cord-280878-1kt51viz	323	23	AM2	am2	NN
cord-280878-1kt51viz	323	24	protein	protein	NN
cord-280878-1kt51viz	323	25	,	,	,
cord-280878-1kt51viz	323	26	ie	ie	FW
cord-280878-1kt51viz	323	27	,	,	,
cord-280878-1kt51viz	323	28	the	the	DT
cord-280878-1kt51viz	323	29	presence	presence	NN
cord-280878-1kt51viz	323	30	of	of	IN
cord-280878-1kt51viz	323	31	two	two	CD
cord-280878-1kt51viz	323	32	binding	bind	VBG
cord-280878-1kt51viz	323	33	sites	site	NNS
cord-280878-1kt51viz	323	34	,	,	,
cord-280878-1kt51viz	323	35	one	one	CD
cord-280878-1kt51viz	323	36	pore	pore	NN
cord-280878-1kt51viz	323	37	-	-	HYPH
cord-280878-1kt51viz	323	38	binding	binding	NN
cord-280878-1kt51viz	323	39	and	and	CC
cord-280878-1kt51viz	323	40	one	one	CD
cord-280878-1kt51viz	323	41	surface	surface	NN
cord-280878-1kt51viz	323	42	-	-	HYPH
cord-280878-1kt51viz	323	43	binding	binding	NN
cord-280878-1kt51viz	323	44	in	in	IN
cord-280878-1kt51viz	323	45	the	the	DT
cord-280878-1kt51viz	323	46	TM	TM	NNP
cord-280878-1kt51viz	323	47	domain	domain	NN
cord-280878-1kt51viz	323	48	.	.	.
cord-280878-1kt51viz	324	1	This	this	DT
cord-280878-1kt51viz	324	2	structure	structure	NN
cord-280878-1kt51viz	324	3	provided	provide	VBD
cord-280878-1kt51viz	324	4	a	a	DT
cord-280878-1kt51viz	324	5	possible	possible	JJ
cord-280878-1kt51viz	324	6	rationale	rationale	NN
cord-280878-1kt51viz	324	7	for	for	IN
cord-280878-1kt51viz	324	8	inhibition	inhibition	NN
cord-280878-1kt51viz	324	9	and	and	CC
cord-280878-1kt51viz	324	10	a	a	DT
cord-280878-1kt51viz	324	11	platform	platform	NN
cord-280878-1kt51viz	324	12	for	for	IN
cord-280878-1kt51viz	324	13	future	future	JJ
cord-280878-1kt51viz	324	14	structure	structure	NN
cord-280878-1kt51viz	324	15	-	-	HYPH
cord-280878-1kt51viz	324	16	based	base	VBN
cord-280878-1kt51viz	324	17	drug	drug	NN
cord-280878-1kt51viz	324	18	design	design	NN
cord-280878-1kt51viz	324	19	of	of	IN
cord-280878-1kt51viz	324	20	this	this	DT
cord-280878-1kt51viz	324	21	potential	potential	JJ
cord-280878-1kt51viz	324	22	pharmacological	pharmacological	JJ
cord-280878-1kt51viz	324	23	target	target	NN
cord-280878-1kt51viz	324	24	.	.	.
cord-280878-1kt51viz	325	1	The	the	DT
cord-280878-1kt51viz	325	2	small	small	JJ
cord-280878-1kt51viz	325	3	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	325	4	(	(	-LRB-
cord-280878-1kt51viz	325	5	SH	sh	NN
cord-280878-1kt51viz	325	6	)	)	-RRB-
cord-280878-1kt51viz	325	7	protein	protein	NN
cord-280878-1kt51viz	325	8	is	be	VBZ
cord-280878-1kt51viz	325	9	found	find	VBN
cord-280878-1kt51viz	325	10	in	in	IN
cord-280878-1kt51viz	325	11	the	the	DT
cord-280878-1kt51viz	325	12	human	human	JJ
cord-280878-1kt51viz	325	13	respiratory	respiratory	JJ
cord-280878-1kt51viz	325	14	syncytial	syncytial	JJ
cord-280878-1kt51viz	325	15	virus	virus	NN
cord-280878-1kt51viz	325	16	(	(	-LRB-
cord-280878-1kt51viz	325	17	hRSV	hRSV	NNP
cord-280878-1kt51viz	325	18	)	)	-RRB-
cord-280878-1kt51viz	325	19	,	,	,
cord-280878-1kt51viz	325	20	an	an	DT
cord-280878-1kt51viz	325	21	enveloped	envelop	VBN
cord-280878-1kt51viz	325	22	pneumovirus	pneumovirus	NN
cord-280878-1kt51viz	325	23	in	in	IN
cord-280878-1kt51viz	325	24	the	the	DT
cord-280878-1kt51viz	325	25	Paramyxoviridae	Paramyxoviridae	NNP
cord-280878-1kt51viz	325	26	family	family	NN
cord-280878-1kt51viz	325	27	.	.	.
cord-280878-1kt51viz	326	1	hRSV	hRSV	NNP
cord-280878-1kt51viz	326	2	is	be	VBZ
cord-280878-1kt51viz	326	3	the	the	DT
cord-280878-1kt51viz	326	4	leading	leading	JJ
cord-280878-1kt51viz	326	5	cause	cause	NN
cord-280878-1kt51viz	326	6	of	of	IN
cord-280878-1kt51viz	326	7	bronchiolitis	bronchiolitis	NN
cord-280878-1kt51viz	326	8	and	and	CC
cord-280878-1kt51viz	326	9	pneumonia	pneumonia	NN
cord-280878-1kt51viz	326	10	in	in	IN
cord-280878-1kt51viz	326	11	infants	infant	NNS
cord-280878-1kt51viz	326	12	and	and	CC
cord-280878-1kt51viz	326	13	elderly	elderly	JJ
cord-280878-1kt51viz	326	14	(	(	-LRB-
cord-280878-1kt51viz	326	15	Dowell	Dowell	NNP
cord-280878-1kt51viz	326	16	et	et	FW
cord-280878-1kt51viz	326	17	al	al	NNP
cord-280878-1kt51viz	326	18	.	.	NNP
cord-280878-1kt51viz	326	19	,	,	,
cord-280878-1kt51viz	326	20	1996	1996	CD
cord-280878-1kt51viz	326	21	)	)	-RRB-
cord-280878-1kt51viz	326	22	,	,	,
cord-280878-1kt51viz	326	23	and	and	CC
cord-280878-1kt51viz	326	24	the	the	DT
cord-280878-1kt51viz	326	25	most	most	RBS
cord-280878-1kt51viz	326	26	frequent	frequent	JJ
cord-280878-1kt51viz	326	27	cause	cause	NN
cord-280878-1kt51viz	326	28	of	of	IN
cord-280878-1kt51viz	326	29	hospitalization	hospitalization	NN
cord-280878-1kt51viz	326	30	of	of	IN
cord-280878-1kt51viz	326	31	infants	infant	NNS
cord-280878-1kt51viz	326	32	and	and	CC
cord-280878-1kt51viz	326	33	young	young	JJ
cord-280878-1kt51viz	326	34	children	child	NNS
cord-280878-1kt51viz	326	35	in	in	IN
cord-280878-1kt51viz	326	36	industrialized	industrialize	VBN
cord-280878-1kt51viz	326	37	countries	country	NNS
cord-280878-1kt51viz	326	38	.	.	.
cord-280878-1kt51viz	327	1	In	in	IN
cord-280878-1kt51viz	327	2	developing	develop	VBG
cord-280878-1kt51viz	327	3	countries	country	NNS
cord-280878-1kt51viz	327	4	,	,	,
cord-280878-1kt51viz	327	5	hRSV	hRSV	NNP
cord-280878-1kt51viz	327	6	is	be	VBZ
cord-280878-1kt51viz	327	7	a	a	DT
cord-280878-1kt51viz	327	8	significant	significant	JJ
cord-280878-1kt51viz	327	9	cause	cause	NN
cord-280878-1kt51viz	327	10	of	of	IN
cord-280878-1kt51viz	327	11	death	death	NN
cord-280878-1kt51viz	327	12	,	,	,
cord-280878-1kt51viz	327	13	with	with	IN
cord-280878-1kt51viz	327	14	global	global	JJ
cord-280878-1kt51viz	327	15	estimates	estimate	NNS
cord-280878-1kt51viz	327	16	of	of	IN
cord-280878-1kt51viz	327	17	more	more	JJR
cord-280878-1kt51viz	327	18	than	than	IN
cord-280878-1kt51viz	327	19	70,000	70,000	CD
cord-280878-1kt51viz	327	20	deaths	death	NNS
cord-280878-1kt51viz	327	21	in	in	IN
cord-280878-1kt51viz	327	22	young	young	JJ
cord-280878-1kt51viz	327	23	children	child	NNS
cord-280878-1kt51viz	327	24	.	.	.
cord-280878-1kt51viz	328	1	hRSV	hRSV	NNP
cord-280878-1kt51viz	328	2	is	be	VBZ
cord-280878-1kt51viz	328	3	the	the	DT
cord-280878-1kt51viz	328	4	third	third	JJ
cord-280878-1kt51viz	328	5	most	most	RBS
cord-280878-1kt51viz	328	6	important	important	JJ
cord-280878-1kt51viz	328	7	cause	cause	NN
cord-280878-1kt51viz	328	8	of	of	IN
cord-280878-1kt51viz	328	9	deadly	deadly	JJ
cord-280878-1kt51viz	328	10	childhood	childhood	NN
cord-280878-1kt51viz	328	11	pneumonia	pneumonia	NN
cord-280878-1kt51viz	328	12	after	after	IN
cord-280878-1kt51viz	328	13	Streptococcus	streptococcus	NN
cord-280878-1kt51viz	328	14	pneumoniae	pneumoniae	NN
cord-280878-1kt51viz	328	15	and	and	CC
cord-280878-1kt51viz	328	16	Haemophilus	haemophilus	JJ
cord-280878-1kt51viz	328	17	influenzae	influenzae	NN
cord-280878-1kt51viz	328	18	(	(	-LRB-
cord-280878-1kt51viz	328	19	Nair	Nair	NNP
cord-280878-1kt51viz	328	20	et	et	NNP
cord-280878-1kt51viz	328	21	al	al	NNP
cord-280878-1kt51viz	328	22	.	.	NNP
cord-280878-1kt51viz	328	23	,	,	,
cord-280878-1kt51viz	328	24	2010	2010	CD
cord-280878-1kt51viz	328	25	)	)	-RRB-
cord-280878-1kt51viz	328	26	.	.	.
cord-280878-1kt51viz	329	1	Several	several	JJ
cord-280878-1kt51viz	329	2	compounds	compound	NNS
cord-280878-1kt51viz	329	3	target	target	VBP
cord-280878-1kt51viz	329	4	the	the	DT
cord-280878-1kt51viz	329	5	RSV	RSV	NNP
cord-280878-1kt51viz	329	6	fusion	fusion	NN
cord-280878-1kt51viz	329	7	(	(	-LRB-
cord-280878-1kt51viz	329	8	F	F	NNP
cord-280878-1kt51viz	329	9	)	)	-RRB-
cord-280878-1kt51viz	329	10	protein	protein	NN
cord-280878-1kt51viz	329	11	,	,	,
cord-280878-1kt51viz	329	12	which	which	WDT
cord-280878-1kt51viz	329	13	facilitates	facilitate	VBZ
cord-280878-1kt51viz	329	14	viral	viral	JJ
cord-280878-1kt51viz	329	15	entry	entry	NN
cord-280878-1kt51viz	329	16	through	through	IN
cord-280878-1kt51viz	329	17	the	the	DT
cord-280878-1kt51viz	329	18	host	host	NN
cord-280878-1kt51viz	329	19	cell	cell	NN
cord-280878-1kt51viz	329	20	membrane	membrane	NN
cord-280878-1kt51viz	329	21	(	(	-LRB-
cord-280878-1kt51viz	329	22	Zhao	Zhao	NNP
cord-280878-1kt51viz	329	23	,	,	,
cord-280878-1kt51viz	329	24	Singh	Singh	NNP
cord-280878-1kt51viz	329	25	,	,	,
cord-280878-1kt51viz	329	26	Malashkevich	Malashkevich	NNP
cord-280878-1kt51viz	329	27	,	,	,
cord-280878-1kt51viz	329	28	&	&	CC
cord-280878-1kt51viz	329	29	Figure	Figure	NNP
cord-280878-1kt51viz	329	30	6	6	CD
cord-280878-1kt51viz	329	31	Binding	Binding	NNP
cord-280878-1kt51viz	329	32	of	of	IN
cord-280878-1kt51viz	329	33	HMA	HMA	NNP
cord-280878-1kt51viz	329	34	to	to	IN
cord-280878-1kt51viz	329	35	the	the	DT
cord-280878-1kt51viz	329	36	SARS	SARS	NNP
cord-280878-1kt51viz	329	37	-	-	HYPH
cord-280878-1kt51viz	329	38	CoV	CoV	NNP
cord-280878-1kt51viz	329	39	E	E	NNP
cord-280878-1kt51viz	329	40	-	-	HYPH
cord-280878-1kt51viz	329	41	TM	TM	NNP
cord-280878-1kt51viz	329	42	pentameric	pentameric	NN
cord-280878-1kt51viz	329	43	channel	channel	NN
cord-280878-1kt51viz	329	44	(	(	-LRB-
cord-280878-1kt51viz	329	45	Pervushin	Pervushin	NNP
cord-280878-1kt51viz	329	46	et	et	FW
cord-280878-1kt51viz	329	47	al	al	NNP
cord-280878-1kt51viz	329	48	.	.	NNP
cord-280878-1kt51viz	329	49	,	,	,
cord-280878-1kt51viz	329	50	2009	2009	CD
cord-280878-1kt51viz	329	51	)	)	-RRB-
cord-280878-1kt51viz	329	52	.	.	.
cord-280878-1kt51viz	330	1	(	(	-LRB-
cord-280878-1kt51viz	330	2	A	a	DT
cord-280878-1kt51viz	330	3	)	)	-RRB-
cord-280878-1kt51viz	330	4	Side	side	JJ
cord-280878-1kt51viz	330	5	view	view	NN
cord-280878-1kt51viz	330	6	of	of	IN
cord-280878-1kt51viz	330	7	the	the	DT
cord-280878-1kt51viz	330	8	binding	binding	NN
cord-280878-1kt51viz	330	9	of	of	IN
cord-280878-1kt51viz	330	10	HMA	HMA	NNP
cord-280878-1kt51viz	330	11	to	to	IN
cord-280878-1kt51viz	330	12	the	the	DT
cord-280878-1kt51viz	330	13	vicinity	vicinity	NN
cord-280878-1kt51viz	330	14	of	of	IN
cord-280878-1kt51viz	330	15	Asn-15	Asn-15	NNP
cord-280878-1kt51viz	330	16	.	.	.
cord-280878-1kt51viz	331	1	The	the	DT
cord-280878-1kt51viz	331	2	side	side	NN
cord-280878-1kt51viz	331	3	chains	chain	NNS
cord-280878-1kt51viz	331	4	of	of	IN
cord-280878-1kt51viz	331	5	amino	amino	JJ
cord-280878-1kt51viz	331	6	acids	acid	NNS
cord-280878-1kt51viz	331	7	interacting	interact	VBG
cord-280878-1kt51viz	331	8	with	with	IN
cord-280878-1kt51viz	331	9	HMA	HMA	NNP
cord-280878-1kt51viz	331	10	are	be	VBP
cord-280878-1kt51viz	331	11	shown	show	VBN
cord-280878-1kt51viz	331	12	using	use	VBG
cord-280878-1kt51viz	331	13	a	a	DT
cord-280878-1kt51viz	331	14	stick	stick	NN
cord-280878-1kt51viz	331	15	representation	representation	NN
cord-280878-1kt51viz	331	16	;	;	:
cord-280878-1kt51viz	331	17	(	(	-LRB-
cord-280878-1kt51viz	331	18	B	b	NN
cord-280878-1kt51viz	331	19	)	)	-RRB-
cord-280878-1kt51viz	331	20	binding	binding	NN
cord-280878-1kt51viz	331	21	of	of	IN
cord-280878-1kt51viz	331	22	HMA	HMA	NNP
cord-280878-1kt51viz	331	23	to	to	IN
cord-280878-1kt51viz	331	24	the	the	DT
cord-280878-1kt51viz	331	25	C	C	NNP
cord-280878-1kt51viz	331	26	-	-	HYPH
cord-280878-1kt51viz	331	27	terminal	terminal	NN
cord-280878-1kt51viz	331	28	binding	binding	NN
cord-280878-1kt51viz	331	29	site	site	NN
cord-280878-1kt51viz	331	30	of	of	IN
cord-280878-1kt51viz	331	31	the	the	DT
cord-280878-1kt51viz	331	32	channel	channel	NN
cord-280878-1kt51viz	331	33	,	,	,
cord-280878-1kt51viz	331	34	in	in	IN
cord-280878-1kt51viz	331	35	the	the	DT
cord-280878-1kt51viz	331	36	vicinity	vicinity	NN
cord-280878-1kt51viz	331	37	of	of	IN
cord-280878-1kt51viz	331	38	Thr-35	Thr-35	NNP
cord-280878-1kt51viz	331	39	and	and	CC
cord-280878-1kt51viz	331	40	Arg-38	Arg-38	NNP
cord-280878-1kt51viz	331	41	.	.	.
cord-280878-1kt51viz	332	1	For	for	IN
cord-280878-1kt51viz	332	2	clarity	clarity	NN
cord-280878-1kt51viz	332	3	,	,	,
cord-280878-1kt51viz	332	4	one	one	CD
cord-280878-1kt51viz	332	5	of	of	IN
cord-280878-1kt51viz	332	6	the	the	DT
cord-280878-1kt51viz	332	7	E	E	NNP
cord-280878-1kt51viz	332	8	-	-	NN
cord-280878-1kt51viz	332	9	TM	TM	NNP
cord-280878-1kt51viz	332	10	monomers	monomer	NNS
cord-280878-1kt51viz	332	11	has	have	VBZ
cord-280878-1kt51viz	332	12	been	be	VBN
cord-280878-1kt51viz	332	13	removed	remove	VBN
cord-280878-1kt51viz	332	14	.	.	.
cord-280878-1kt51viz	333	1	Kim	Kim	NNP
cord-280878-1kt51viz	333	2	,	,	,
cord-280878-1kt51viz	333	3	2000	2000	CD
cord-280878-1kt51viz	333	4	)	)	-RRB-
cord-280878-1kt51viz	333	5	through	through	IN
cord-280878-1kt51viz	333	6	formation	formation	NN
cord-280878-1kt51viz	333	7	of	of	IN
cord-280878-1kt51viz	333	8	a	a	DT
cord-280878-1kt51viz	333	9	6-helix	6-helix	CD
cord-280878-1kt51viz	333	10	bundle	bundle	NN
cord-280878-1kt51viz	333	11	(	(	-LRB-
cord-280878-1kt51viz	333	12	Douglas	Douglas	NNP
cord-280878-1kt51viz	333	13	et	et	NNP
cord-280878-1kt51viz	333	14	al	al	NNP
cord-280878-1kt51viz	333	15	.	.	NNP
cord-280878-1kt51viz	333	16	,	,	,
cord-280878-1kt51viz	333	17	2005	2005	CD
cord-280878-1kt51viz	333	18	;	;	:
cord-280878-1kt51viz	333	19	Lambert	Lambert	NNP
cord-280878-1kt51viz	333	20	et	et	NNP
cord-280878-1kt51viz	333	21	al	al	NNP
cord-280878-1kt51viz	333	22	.	.	NNP
cord-280878-1kt51viz	333	23	,	,	,
cord-280878-1kt51viz	333	24	1996	1996	CD
cord-280878-1kt51viz	333	25	;	;	.
cord-280878-1kt51viz	334	1	Pastey	Pastey	NNP
cord-280878-1kt51viz	334	2	,	,	,
cord-280878-1kt51viz	334	3	Gower	Gower	NNP
cord-280878-1kt51viz	334	4	,	,	,
cord-280878-1kt51viz	334	5	Spearman	Spearman	NNP
cord-280878-1kt51viz	334	6	,	,	,
cord-280878-1kt51viz	334	7	Crowe	Crowe	NNP
cord-280878-1kt51viz	334	8	,	,	,
cord-280878-1kt51viz	334	9	&	&	CC
cord-280878-1kt51viz	334	10	Graham	Graham	NNP
cord-280878-1kt51viz	334	11	,	,	,
cord-280878-1kt51viz	334	12	2000	2000	CD
cord-280878-1kt51viz	334	13	;	;	:
cord-280878-1kt51viz	334	14	Razinkov	Razinkov	NNP
cord-280878-1kt51viz	334	15	,	,	,
cord-280878-1kt51viz	334	16	Gazumyan	Gazumyan	NNP
cord-280878-1kt51viz	334	17	,	,	,
cord-280878-1kt51viz	334	18	Nikitenko	Nikitenko	NNP
cord-280878-1kt51viz	334	19	,	,	,
cord-280878-1kt51viz	334	20	Ellestad	Ellestad	NNP
cord-280878-1kt51viz	334	21	,	,	,
cord-280878-1kt51viz	334	22	&	&	CC
cord-280878-1kt51viz	334	23	Krishnamurthy	Krishnamurthy	NNP
cord-280878-1kt51viz	334	24	,	,	,
cord-280878-1kt51viz	334	25	2001	2001	CD
cord-280878-1kt51viz	334	26	;	;	:
cord-280878-1kt51viz	334	27	Roymans	Roymans	NNPS
cord-280878-1kt51viz	334	28	et	et	NNP
cord-280878-1kt51viz	334	29	al	al	NNP
cord-280878-1kt51viz	334	30	.	.	NNP
cord-280878-1kt51viz	334	31	,	,	,
cord-280878-1kt51viz	334	32	2010	2010	CD
cord-280878-1kt51viz	334	33	;	;	:
cord-280878-1kt51viz	334	34	Shepherd	Shepherd	NNP
cord-280878-1kt51viz	334	35	et	et	NNP
cord-280878-1kt51viz	334	36	al	al	NNP
cord-280878-1kt51viz	334	37	.	.	NNP
cord-280878-1kt51viz	334	38	,	,	,
cord-280878-1kt51viz	334	39	2006	2006	CD
cord-280878-1kt51viz	334	40	)	)	-RRB-
cord-280878-1kt51viz	334	41	.	.	.
cord-280878-1kt51viz	335	1	Other	other	JJ
cord-280878-1kt51viz	335	2	approaches	approach	NNS
cord-280878-1kt51viz	335	3	have	have	VBP
cord-280878-1kt51viz	335	4	involved	involve	VBN
cord-280878-1kt51viz	335	5	gene	gene	NN
cord-280878-1kt51viz	335	6	transfer	transfer	NN
cord-280878-1kt51viz	335	7	to	to	TO
cord-280878-1kt51viz	335	8	expose	expose	VB
cord-280878-1kt51viz	335	9	viral	viral	JJ
cord-280878-1kt51viz	335	10	proteins	protein	NNS
cord-280878-1kt51viz	335	11	to	to	IN
cord-280878-1kt51viz	335	12	cells	cell	NNS
cord-280878-1kt51viz	335	13	(	(	-LRB-
cord-280878-1kt51viz	335	14	Kumar	Kumar	NNP
cord-280878-1kt51viz	335	15	et	et	NNP
cord-280878-1kt51viz	335	16	al	al	NNP
cord-280878-1kt51viz	335	17	.	.	NNP
cord-280878-1kt51viz	335	18	,	,	,
cord-280878-1kt51viz	335	19	2002	2002	CD
cord-280878-1kt51viz	335	20	)	)	-RRB-
cord-280878-1kt51viz	335	21	,	,	,
cord-280878-1kt51viz	335	22	or	or	CC
cord-280878-1kt51viz	335	23	siRNA	siRNA	NNP
cord-280878-1kt51viz	335	24	against	against	IN
cord-280878-1kt51viz	335	25	specific	specific	JJ
cord-280878-1kt51viz	335	26	viral	viral	JJ
cord-280878-1kt51viz	335	27	proteins	protein	NNS
cord-280878-1kt51viz	336	1	(	(	-LRB-
cord-280878-1kt51viz	336	2	Zhang	Zhang	NNP
cord-280878-1kt51viz	336	3	et	et	NNP
cord-280878-1kt51viz	336	4	al	al	NNP
cord-280878-1kt51viz	336	5	.	.	NNP
cord-280878-1kt51viz	336	6	,	,	,
cord-280878-1kt51viz	336	7	2005	2005	CD
cord-280878-1kt51viz	336	8	)	)	-RRB-
cord-280878-1kt51viz	336	9	.	.	.
cord-280878-1kt51viz	337	1	Vaccines	vaccine	NNS
cord-280878-1kt51viz	337	2	have	have	VBP
cord-280878-1kt51viz	337	3	been	be	VBN
cord-280878-1kt51viz	337	4	recently	recently	RB
cord-280878-1kt51viz	337	5	designed	design	VBN
cord-280878-1kt51viz	337	6	based	base	VBN
cord-280878-1kt51viz	337	7	on	on	IN
cord-280878-1kt51viz	337	8	a	a	DT
cord-280878-1kt51viz	337	9	stabilized	stabilize	VBN
cord-280878-1kt51viz	337	10	RSV	RSV	NNP
cord-280878-1kt51viz	337	11	-	-	HYPH
cord-280878-1kt51viz	337	12	F	F	NNP
cord-280878-1kt51viz	337	13	form	form	NN
cord-280878-1kt51viz	337	14	which	which	WDT
cord-280878-1kt51viz	337	15	preserves	preserve	VBZ
cord-280878-1kt51viz	337	16	a	a	DT
cord-280878-1kt51viz	337	17	highly	highly	RB
cord-280878-1kt51viz	337	18	antigenic	antigenic	JJ
cord-280878-1kt51viz	337	19	site	site	NN
cord-280878-1kt51viz	337	20	in	in	IN
cord-280878-1kt51viz	337	21	its	-PRON-	PRP$
cord-280878-1kt51viz	337	22	prefusion	prefusion	NN
cord-280878-1kt51viz	337	23	state	state	NN
cord-280878-1kt51viz	337	24	,	,	,
cord-280878-1kt51viz	337	25	yielding	yield	VBG
cord-280878-1kt51viz	337	26	RSV	rsv	NN
cord-280878-1kt51viz	337	27	-	-	HYPH
cord-280878-1kt51viz	337	28	specific	specific	JJ
cord-280878-1kt51viz	337	29	neutralizing	neutralize	VBG
cord-280878-1kt51viz	337	30	antibodies	antibody	NNS
cord-280878-1kt51viz	337	31	in	in	IN
cord-280878-1kt51viz	337	32	mice	mouse	NNS
cord-280878-1kt51viz	337	33	and	and	CC
cord-280878-1kt51viz	337	34	macaques	macaque	NNS
cord-280878-1kt51viz	337	35	(	(	-LRB-
cord-280878-1kt51viz	337	36	McLellan	McLellan	NNP
cord-280878-1kt51viz	337	37	,	,	,
cord-280878-1kt51viz	337	38	Chen	Chen	NNP
cord-280878-1kt51viz	337	39	,	,	,
cord-280878-1kt51viz	337	40	Joyce	Joyce	NNP
cord-280878-1kt51viz	337	41	,	,	,
cord-280878-1kt51viz	337	42	et	et	NNP
cord-280878-1kt51viz	337	43	al	al	NNP
cord-280878-1kt51viz	337	44	.	.	NNP
cord-280878-1kt51viz	337	45	,	,	,
cord-280878-1kt51viz	337	46	2013	2013	CD
cord-280878-1kt51viz	337	47	;	;	:
cord-280878-1kt51viz	337	48	McLellan	McLellan	NNP
cord-280878-1kt51viz	337	49	,	,	,
cord-280878-1kt51viz	337	50	Chen	Chen	NNP
cord-280878-1kt51viz	337	51	,	,	,
cord-280878-1kt51viz	337	52	Leung	Leung	NNP
cord-280878-1kt51viz	337	53	,	,	,
cord-280878-1kt51viz	337	54	et	et	NNP
cord-280878-1kt51viz	337	55	al	al	NNP
cord-280878-1kt51viz	337	56	.	.	NNP
cord-280878-1kt51viz	337	57	,	,	,
cord-280878-1kt51viz	337	58	2013	2013	CD
cord-280878-1kt51viz	337	59	)	)	-RRB-
cord-280878-1kt51viz	337	60	.	.	.
cord-280878-1kt51viz	338	1	Recently	recently	RB
cord-280878-1kt51viz	338	2	,	,	,
cord-280878-1kt51viz	338	3	a	a	DT
cord-280878-1kt51viz	338	4	vaccine	vaccine	NN
cord-280878-1kt51viz	338	5	candidate	candidate	NN
cord-280878-1kt51viz	338	6	based	base	VBN
cord-280878-1kt51viz	338	7	on	on	IN
cord-280878-1kt51viz	338	8	the	the	DT
cord-280878-1kt51viz	338	9	extracellular	extracellular	JJ
cord-280878-1kt51viz	338	10	domain	domain	NN
cord-280878-1kt51viz	338	11	(	(	-LRB-
cord-280878-1kt51viz	338	12	C	c	NN
cord-280878-1kt51viz	338	13	-	-	HYPH
cord-280878-1kt51viz	338	14	terminal	terminal	NN
cord-280878-1kt51viz	338	15	)	)	-RRB-
cord-280878-1kt51viz	338	16	of	of	IN
cord-280878-1kt51viz	338	17	the	the	DT
cord-280878-1kt51viz	338	18	RSV	RSV	NNP
cord-280878-1kt51viz	338	19	viroporin	viroporin	NNP
cord-280878-1kt51viz	338	20	,	,	,
cord-280878-1kt51viz	338	21	the	the	DT
cord-280878-1kt51viz	338	22	small	small	JJ
cord-280878-1kt51viz	338	23	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	338	24	(	(	-LRB-
cord-280878-1kt51viz	338	25	SH	SH	NNP
cord-280878-1kt51viz	338	26	)	)	-RRB-
cord-280878-1kt51viz	338	27	protein	protein	NN
cord-280878-1kt51viz	338	28	,	,	,
cord-280878-1kt51viz	338	29	has	have	VBZ
cord-280878-1kt51viz	338	30	been	be	VBN
cord-280878-1kt51viz	338	31	reported	report	VBN
cord-280878-1kt51viz	339	1	(	(	-LRB-
cord-280878-1kt51viz	339	2	Schepens	Schepens	NNP
cord-280878-1kt51viz	339	3	et	et	NNP
cord-280878-1kt51viz	339	4	al	al	NNP
cord-280878-1kt51viz	339	5	.	.	NNP
cord-280878-1kt51viz	339	6	,	,	,
cord-280878-1kt51viz	339	7	2014	2014	CD
cord-280878-1kt51viz	339	8	)	)	-RRB-
cord-280878-1kt51viz	339	9	.	.	.
cord-280878-1kt51viz	340	1	In	in	IN
cord-280878-1kt51viz	340	2	addition	addition	NN
cord-280878-1kt51viz	340	3	,	,	,
cord-280878-1kt51viz	340	4	the	the	DT
cord-280878-1kt51viz	340	5	prevention	prevention	NN
cord-280878-1kt51viz	340	6	of	of	IN
cord-280878-1kt51viz	340	7	nasopulmonary	nasopulmonary	JJ
cord-280878-1kt51viz	340	8	infection	infection	NN
cord-280878-1kt51viz	340	9	in	in	IN
cord-280878-1kt51viz	340	10	mice	mouse	NNS
cord-280878-1kt51viz	340	11	caused	cause	VBN
cord-280878-1kt51viz	340	12	by	by	IN
cord-280878-1kt51viz	340	13	RSV	RSV	NNP
cord-280878-1kt51viz	340	14	has	have	VBZ
cord-280878-1kt51viz	340	15	been	be	VBN
cord-280878-1kt51viz	340	16	reported	report	VBN
cord-280878-1kt51viz	340	17	using	use	VBG
cord-280878-1kt51viz	340	18	stapled	staple	VBN
cord-280878-1kt51viz	340	19	peptides	peptide	NNS
cord-280878-1kt51viz	340	20	targeting	target	VBG
cord-280878-1kt51viz	340	21	the	the	DT
cord-280878-1kt51viz	340	22	fusogenic	fusogenic	NNP
cord-280878-1kt51viz	340	23	F	F	NNP
cord-280878-1kt51viz	340	24	-	-	HYPH
cord-280878-1kt51viz	340	25	protein	protein	NNP
cord-280878-1kt51viz	340	26	6-helix	6-helix	CD
cord-280878-1kt51viz	340	27	bundle	bundle	NN
cord-280878-1kt51viz	340	28	.	.	.
cord-280878-1kt51viz	341	1	However	however	RB
cord-280878-1kt51viz	341	2	,	,	,
cord-280878-1kt51viz	341	3	despite	despite	IN
cord-280878-1kt51viz	341	4	all	all	PDT
cord-280878-1kt51viz	341	5	these	these	DT
cord-280878-1kt51viz	341	6	efforts	effort	NNS
cord-280878-1kt51viz	341	7	,	,	,
cord-280878-1kt51viz	341	8	new	new	JJ
cord-280878-1kt51viz	341	9	FDA	FDA	NNP
cord-280878-1kt51viz	341	10	-	-	HYPH
cord-280878-1kt51viz	341	11	approved	approve	VBN
cord-280878-1kt51viz	341	12	drugs	drug	NNS
cord-280878-1kt51viz	341	13	have	have	VBP
cord-280878-1kt51viz	341	14	yet	yet	RB
cord-280878-1kt51viz	341	15	to	to	TO
cord-280878-1kt51viz	341	16	emerge	emerge	VB
cord-280878-1kt51viz	341	17	.	.	.
cord-280878-1kt51viz	342	1	The	the	DT
cord-280878-1kt51viz	342	2	only	only	JJ
cord-280878-1kt51viz	342	3	licensed	license	VBN
cord-280878-1kt51viz	342	4	drug	drug	NN
cord-280878-1kt51viz	342	5	for	for	IN
cord-280878-1kt51viz	342	6	use	use	NN
cord-280878-1kt51viz	342	7	in	in	IN
cord-280878-1kt51viz	342	8	infected	infected	JJ
cord-280878-1kt51viz	342	9	individuals	individual	NNS
cord-280878-1kt51viz	342	10	is	be	VBZ
cord-280878-1kt51viz	342	11	ribavirin	ribavirin	NN
cord-280878-1kt51viz	342	12	,	,	,
cord-280878-1kt51viz	342	13	a	a	DT
cord-280878-1kt51viz	342	14	nucleoside	nucleoside	NN
cord-280878-1kt51viz	342	15	analogue	analogue	NN
cord-280878-1kt51viz	342	16	,	,	,
cord-280878-1kt51viz	342	17	but	but	CC
cord-280878-1kt51viz	342	18	its	-PRON-	PRP$
cord-280878-1kt51viz	342	19	efficacy	efficacy	NN
cord-280878-1kt51viz	342	20	is	be	VBZ
cord-280878-1kt51viz	342	21	very	very	RB
cord-280878-1kt51viz	342	22	limited	limited	JJ
cord-280878-1kt51viz	342	23	(	(	-LRB-
cord-280878-1kt51viz	342	24	Hall	Hall	NNP
cord-280878-1kt51viz	342	25	et	et	NNP
cord-280878-1kt51viz	342	26	al	al	NNP
cord-280878-1kt51viz	342	27	.	.	NNP
cord-280878-1kt51viz	342	28	,	,	,
cord-280878-1kt51viz	342	29	1986	1986	CD
cord-280878-1kt51viz	342	30	)	)	-RRB-
cord-280878-1kt51viz	342	31	.	.	.
cord-280878-1kt51viz	343	1	The	the	DT
cord-280878-1kt51viz	343	2	hRSV	hrsv	NN
cord-280878-1kt51viz	343	3	genome	genome	NN
cord-280878-1kt51viz	343	4	transcribes	transcribe	VBZ
cord-280878-1kt51viz	343	5	11	11	CD
cord-280878-1kt51viz	343	6	proteins	protein	NNS
cord-280878-1kt51viz	343	7	(	(	-LRB-
cord-280878-1kt51viz	343	8	Collins	Collins	NNP
cord-280878-1kt51viz	343	9	&	&	CC
cord-280878-1kt51viz	343	10	Melero	Melero	NNP
cord-280878-1kt51viz	343	11	,	,	,
cord-280878-1kt51viz	343	12	2011	2011	CD
cord-280878-1kt51viz	343	13	)	)	-RRB-
cord-280878-1kt51viz	343	14	.	.	.
cord-280878-1kt51viz	344	1	One	one	CD
cord-280878-1kt51viz	344	2	of	of	IN
cord-280878-1kt51viz	344	3	these	these	DT
cord-280878-1kt51viz	344	4	is	be	VBZ
cord-280878-1kt51viz	344	5	the	the	DT
cord-280878-1kt51viz	344	6	viroporin	viroporin	NN
cord-280878-1kt51viz	344	7	SH	sh	NN
cord-280878-1kt51viz	344	8	protein	protein	NN
cord-280878-1kt51viz	344	9	,	,	,
cord-280878-1kt51viz	344	10	which	which	WDT
cord-280878-1kt51viz	344	11	is	be	VBZ
cord-280878-1kt51viz	344	12	64	64	CD
cord-280878-1kt51viz	344	13	-	-	SYM
cord-280878-1kt51viz	344	14	65	65	CD
cord-280878-1kt51viz	344	15	residues	residue	NNS
cord-280878-1kt51viz	344	16	long	long	JJ
cord-280878-1kt51viz	344	17	(	(	-LRB-
cord-280878-1kt51viz	344	18	depending	depend	VBG
cord-280878-1kt51viz	344	19	on	on	IN
cord-280878-1kt51viz	344	20	subgroup	subgroup	NN
cord-280878-1kt51viz	344	21	,	,	,
cord-280878-1kt51viz	344	22	A	a	NN
cord-280878-1kt51viz	344	23	or	or	CC
cord-280878-1kt51viz	344	24	B	b	NN
cord-280878-1kt51viz	344	25	)	)	-RRB-
cord-280878-1kt51viz	344	26	and	and	CC
cord-280878-1kt51viz	344	27	has	have	VBZ
cord-280878-1kt51viz	344	28	a	a	DT
cord-280878-1kt51viz	344	29	single	single	JJ
cord-280878-1kt51viz	344	30	α	α	NN
cord-280878-1kt51viz	344	31	-	-	HYPH
cord-280878-1kt51viz	344	32	helical	helical	JJ
cord-280878-1kt51viz	344	33	TM	TM	NNP
cord-280878-1kt51viz	344	34	domain	domain	NN
cord-280878-1kt51viz	344	35	with	with	IN
cord-280878-1kt51viz	344	36	N	n	CD
cord-280878-1kt51viz	344	37	-	-	:
cord-280878-1kt51viz	344	38	and	and	CC
cord-280878-1kt51viz	344	39	C	C	NNP
cord-280878-1kt51viz	344	40	-	-	HYPH
cord-280878-1kt51viz	344	41	terminal	terminal	NN
cord-280878-1kt51viz	344	42	extramembrane	extramembrane	NNP
cord-280878-1kt51viz	344	43	domains	domain	NNS
cord-280878-1kt51viz	344	44	oriented	orient	VBN
cord-280878-1kt51viz	344	45	cytoplasmically	cytoplasmically	NN
cord-280878-1kt51viz	344	46	and	and	CC
cord-280878-1kt51viz	344	47	lumenally	lumenally	RB
cord-280878-1kt51viz	344	48	/	/	SYM
cord-280878-1kt51viz	344	49	extracellularly	extracellularly	RB
cord-280878-1kt51viz	344	50	,	,	,
cord-280878-1kt51viz	344	51	respectively	respectively	RB
cord-280878-1kt51viz	344	52	(	(	-LRB-
cord-280878-1kt51viz	344	53	Collins	Collins	NNP
cord-280878-1kt51viz	344	54	&	&	CC
cord-280878-1kt51viz	344	55	Mottet	Mottet	NNP
cord-280878-1kt51viz	344	56	,	,	,
cord-280878-1kt51viz	344	57	1993	1993	CD
cord-280878-1kt51viz	344	58	;	;	:
cord-280878-1kt51viz	344	59	Gan	Gan	NNP
cord-280878-1kt51viz	344	60	et	et	NNP
cord-280878-1kt51viz	344	61	al	al	NNP
cord-280878-1kt51viz	344	62	.	.	NNP
cord-280878-1kt51viz	344	63	,	,	,
cord-280878-1kt51viz	344	64	2012	2012	CD
cord-280878-1kt51viz	344	65	)	)	-RRB-
cord-280878-1kt51viz	344	66	.	.	.
cord-280878-1kt51viz	345	1	Most	Most	JJS
cord-280878-1kt51viz	345	2	SH	sh	NN
cord-280878-1kt51viz	345	3	protein	protein	NN
cord-280878-1kt51viz	345	4	accumulates	accumulate	VBZ
cord-280878-1kt51viz	345	5	at	at	IN
cord-280878-1kt51viz	345	6	the	the	DT
cord-280878-1kt51viz	345	7	membranes	membrane	NNS
cord-280878-1kt51viz	345	8	of	of	IN
cord-280878-1kt51viz	345	9	the	the	DT
cord-280878-1kt51viz	345	10	Golgi	Golgi	NNP
cord-280878-1kt51viz	345	11	complex	complex	NN
cord-280878-1kt51viz	345	12	in	in	IN
cord-280878-1kt51viz	345	13	infected	infected	JJ
cord-280878-1kt51viz	345	14	cells	cell	NNS
cord-280878-1kt51viz	345	15	,	,	,
cord-280878-1kt51viz	345	16	but	but	CC
cord-280878-1kt51viz	345	17	it	-PRON-	PRP
cord-280878-1kt51viz	345	18	has	have	VBZ
cord-280878-1kt51viz	345	19	also	also	RB
cord-280878-1kt51viz	345	20	been	be	VBN
cord-280878-1kt51viz	345	21	detected	detect	VBN
cord-280878-1kt51viz	345	22	in	in	IN
cord-280878-1kt51viz	345	23	the	the	DT
cord-280878-1kt51viz	345	24	ER	er	NN
cord-280878-1kt51viz	345	25	and	and	CC
cord-280878-1kt51viz	345	26	plasma	plasma	NN
cord-280878-1kt51viz	345	27	membranes	membrane	NNS
cord-280878-1kt51viz	345	28	(	(	-LRB-
cord-280878-1kt51viz	345	29	Rixon	Rixon	NNP
cord-280878-1kt51viz	345	30	et	et	NNP
cord-280878-1kt51viz	345	31	al	al	NNP
cord-280878-1kt51viz	345	32	.	.	NNP
cord-280878-1kt51viz	345	33	,	,	,
cord-280878-1kt51viz	345	34	2004	2004	CD
cord-280878-1kt51viz	345	35	)	)	-RRB-
cord-280878-1kt51viz	345	36	.	.	.
cord-280878-1kt51viz	346	1	RSV	RSV	NNP
cord-280878-1kt51viz	346	2	that	that	WDT
cord-280878-1kt51viz	346	3	lacks	lack	VBZ
cord-280878-1kt51viz	346	4	SH	sh	NN
cord-280878-1kt51viz	346	5	(	(	-LRB-
cord-280878-1kt51viz	346	6	RSVΔSH	rsvδsh	NN
cord-280878-1kt51viz	346	7	)	)	-RRB-
cord-280878-1kt51viz	346	8	is	be	VBZ
cord-280878-1kt51viz	346	9	still	still	RB
cord-280878-1kt51viz	346	10	viable	viable	JJ
cord-280878-1kt51viz	346	11	,	,	,
cord-280878-1kt51viz	346	12	and	and	CC
cord-280878-1kt51viz	346	13	still	still	RB
cord-280878-1kt51viz	346	14	forms	form	VBZ
cord-280878-1kt51viz	346	15	syncytia	syncytia	NN
cord-280878-1kt51viz	346	16	(	(	-LRB-
cord-280878-1kt51viz	346	17	Bukreyev	Bukreyev	NNP
cord-280878-1kt51viz	346	18	,	,	,
cord-280878-1kt51viz	346	19	Whitehead	Whitehead	NNP
cord-280878-1kt51viz	346	20	,	,	,
cord-280878-1kt51viz	346	21	Murphy	Murphy	NNP
cord-280878-1kt51viz	346	22	,	,	,
cord-280878-1kt51viz	346	23	&	&	CC
cord-280878-1kt51viz	346	24	Collins	Collins	NNP
cord-280878-1kt51viz	346	25	,	,	,
cord-280878-1kt51viz	346	26	1997	1997	CD
cord-280878-1kt51viz	346	27	;	;	:
cord-280878-1kt51viz	346	28	Karron	Karron	NNP
cord-280878-1kt51viz	346	29	et	et	NNP
cord-280878-1kt51viz	346	30	al	al	NNP
cord-280878-1kt51viz	346	31	.	.	NNP
cord-280878-1kt51viz	346	32	,	,	,
cord-280878-1kt51viz	346	33	1997	1997	CD
cord-280878-1kt51viz	346	34	;	;	:
cord-280878-1kt51viz	346	35	Techaarpornkul	Techaarpornkul	NNP
cord-280878-1kt51viz	346	36	,	,	,
cord-280878-1kt51viz	346	37	Barretto	Barretto	NNP
cord-280878-1kt51viz	346	38	,	,	,
cord-280878-1kt51viz	346	39	&	&	CC
cord-280878-1kt51viz	346	40	Peeples	Peeples	NNP
cord-280878-1kt51viz	346	41	,	,	,
cord-280878-1kt51viz	346	42	2001	2001	CD
cord-280878-1kt51viz	346	43	)	)	-RRB-
cord-280878-1kt51viz	346	44	,	,	,
cord-280878-1kt51viz	346	45	but	but	CC
cord-280878-1kt51viz	346	46	is	be	VBZ
cord-280878-1kt51viz	346	47	attenuated	attenuate	VBN
cord-280878-1kt51viz	346	48	in	in	IN
cord-280878-1kt51viz	346	49	vivo	vivo	NNP
cord-280878-1kt51viz	346	50	.	.	.
cord-280878-1kt51viz	347	1	In	in	IN
cord-280878-1kt51viz	347	2	mouse	mouse	NN
cord-280878-1kt51viz	347	3	,	,	,
cord-280878-1kt51viz	347	4	RSV	RSV	NNP
cord-280878-1kt51viz	347	5	ΔSH	ΔSH	NNP
cord-280878-1kt51viz	347	6	replicated	replicate	VBD
cord-280878-1kt51viz	347	7	10-fold	10-fold	CD
cord-280878-1kt51viz	347	8	less	less	RBR
cord-280878-1kt51viz	347	9	efficiently	efficiently	RB
cord-280878-1kt51viz	347	10	in	in	IN
cord-280878-1kt51viz	347	11	the	the	DT
cord-280878-1kt51viz	347	12	upper	upper	JJ
cord-280878-1kt51viz	347	13	respiratory	respiratory	JJ
cord-280878-1kt51viz	347	14	tract	tract	NN
cord-280878-1kt51viz	347	15	(	(	-LRB-
cord-280878-1kt51viz	347	16	Bukreyev	Bukreyev	NNP
cord-280878-1kt51viz	347	17	et	et	NNP
cord-280878-1kt51viz	347	18	al	al	NNP
cord-280878-1kt51viz	347	19	.	.	NNP
cord-280878-1kt51viz	347	20	,	,	,
cord-280878-1kt51viz	347	21	1997	1997	CD
cord-280878-1kt51viz	347	22	)	)	-RRB-
cord-280878-1kt51viz	347	23	,	,	,
cord-280878-1kt51viz	347	24	whereas	whereas	IN
cord-280878-1kt51viz	347	25	chimpanzees	chimpanzee	NNS
cord-280878-1kt51viz	347	26	developed	develop	VBD
cord-280878-1kt51viz	347	27	significantly	significantly	RB
cord-280878-1kt51viz	347	28	less	less	JJR
cord-280878-1kt51viz	347	29	rhinorrhea	rhinorrhea	NN
cord-280878-1kt51viz	347	30	than	than	IN
cord-280878-1kt51viz	347	31	those	those	DT
cord-280878-1kt51viz	347	32	infected	infect	VBN
cord-280878-1kt51viz	347	33	with	with	IN
cord-280878-1kt51viz	347	34	wild	wild	JJ
cord-280878-1kt51viz	347	35	-	-	HYPH
cord-280878-1kt51viz	347	36	type	type	NN
cord-280878-1kt51viz	347	37	RSV	RSV	NNP
cord-280878-1kt51viz	347	38	(	(	-LRB-
cord-280878-1kt51viz	347	39	Whitehead	Whitehead	NNP
cord-280878-1kt51viz	347	40	et	et	NNP
cord-280878-1kt51viz	347	41	al	al	NNP
cord-280878-1kt51viz	347	42	.	.	NNP
cord-280878-1kt51viz	347	43	,	,	,
cord-280878-1kt51viz	347	44	1999	1999	CD
cord-280878-1kt51viz	347	45	)	)	-RRB-
cord-280878-1kt51viz	347	46	.	.	.
cord-280878-1kt51viz	348	1	Other	other	JJ
cord-280878-1kt51viz	348	2	reports	report	NNS
cord-280878-1kt51viz	348	3	have	have	VBP
cord-280878-1kt51viz	348	4	shown	show	VBN
cord-280878-1kt51viz	348	5	that	that	IN
cord-280878-1kt51viz	348	6	the	the	DT
cord-280878-1kt51viz	348	7	lack	lack	NN
cord-280878-1kt51viz	348	8	of	of	IN
cord-280878-1kt51viz	348	9	SH	sh	NN
cord-280878-1kt51viz	348	10	protein	protein	NN
cord-280878-1kt51viz	348	11	leads	lead	VBZ
cord-280878-1kt51viz	348	12	to	to	IN
cord-280878-1kt51viz	348	13	an	an	DT
cord-280878-1kt51viz	348	14	attenuated	attenuated	JJ
cord-280878-1kt51viz	348	15	phenotype	phenotype	NN
cord-280878-1kt51viz	348	16	in	in	IN
cord-280878-1kt51viz	348	17	children	child	NNS
cord-280878-1kt51viz	348	18	and	and	CC
cord-280878-1kt51viz	348	19	in	in	IN
cord-280878-1kt51viz	348	20	rats	rat	NNS
cord-280878-1kt51viz	349	1	(	(	-LRB-
cord-280878-1kt51viz	349	2	Jin	Jin	NNP
cord-280878-1kt51viz	349	3	et	et	FW
cord-280878-1kt51viz	349	4	al	al	NNP
cord-280878-1kt51viz	349	5	.	.	.
cord-280878-1kt51viz	350	1	,	,	,
cord-280878-1kt51viz	350	2	2000	2000	CD
cord-280878-1kt51viz	350	3	;	;	:
cord-280878-1kt51viz	350	4	Karron	Karron	NNP
cord-280878-1kt51viz	350	5	et	et	NNP
cord-280878-1kt51viz	350	6	al	al	NNP
cord-280878-1kt51viz	350	7	.	.	NNP
cord-280878-1kt51viz	350	8	,	,	,
cord-280878-1kt51viz	350	9	1997	1997	CD
cord-280878-1kt51viz	350	10	)	)	-RRB-
cord-280878-1kt51viz	350	11	.	.	.
cord-280878-1kt51viz	351	1	Overall	overall	RB
cord-280878-1kt51viz	351	2	,	,	,
cord-280878-1kt51viz	351	3	these	these	DT
cord-280878-1kt51viz	351	4	results	result	NNS
cord-280878-1kt51viz	351	5	indicate	indicate	VBP
cord-280878-1kt51viz	351	6	involvement	involvement	NN
cord-280878-1kt51viz	351	7	of	of	IN
cord-280878-1kt51viz	351	8	hRSV	hRSV	NNP
cord-280878-1kt51viz	351	9	SH	SH	NNP
cord-280878-1kt51viz	351	10	protein	protein	NN
cord-280878-1kt51viz	351	11	in	in	IN
cord-280878-1kt51viz	351	12	replication	replication	NN
cord-280878-1kt51viz	351	13	and	and	CC
cord-280878-1kt51viz	351	14	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	351	15	.	.	.
cord-280878-1kt51viz	352	1	In	in	IN
cord-280878-1kt51viz	352	2	common	common	JJ
cord-280878-1kt51viz	352	3	to	to	IN
cord-280878-1kt51viz	352	4	the	the	DT
cord-280878-1kt51viz	352	5	SARS	SARS	NNP
cord-280878-1kt51viz	352	6	-	-	HYPH
cord-280878-1kt51viz	352	7	CoV	CoV	NNP
cord-280878-1kt51viz	352	8	E	e	NN
cord-280878-1kt51viz	352	9	protein	protein	NN
cord-280878-1kt51viz	352	10	,	,	,
cord-280878-1kt51viz	352	11	SH	sh	NN
cord-280878-1kt51viz	352	12	protein	protein	NN
cord-280878-1kt51viz	352	13	blocks	block	NNS
cord-280878-1kt51viz	352	14	or	or	CC
cord-280878-1kt51viz	352	15	delays	delay	NNS
cord-280878-1kt51viz	352	16	apoptosis	apoptosis	NN
cord-280878-1kt51viz	352	17	in	in	IN
cord-280878-1kt51viz	352	18	infected	infected	JJ
cord-280878-1kt51viz	352	19	cells	cell	NNS
cord-280878-1kt51viz	352	20	(	(	-LRB-
cord-280878-1kt51viz	352	21	Fuentes	fuente	NNS
cord-280878-1kt51viz	352	22	,	,	,
cord-280878-1kt51viz	352	23	Tran	Tran	NNP
cord-280878-1kt51viz	352	24	,	,	,
cord-280878-1kt51viz	352	25	Luthra	Luthra	NNP
cord-280878-1kt51viz	352	26	,	,	,
cord-280878-1kt51viz	352	27	Teng	Teng	NNP
cord-280878-1kt51viz	352	28	,	,	,
cord-280878-1kt51viz	352	29	&	&	CC
cord-280878-1kt51viz	352	30	He	He	NNP
cord-280878-1kt51viz	352	31	,	,	,
cord-280878-1kt51viz	352	32	2007	2007	CD
cord-280878-1kt51viz	352	33	)	)	-RRB-
cord-280878-1kt51viz	352	34	,	,	,
cord-280878-1kt51viz	352	35	and	and	CC
cord-280878-1kt51viz	352	36	a	a	DT
cord-280878-1kt51viz	352	37	similar	similar	JJ
cord-280878-1kt51viz	352	38	antiapoptotic	antiapoptotic	JJ
cord-280878-1kt51viz	352	39	effect	effect	NN
cord-280878-1kt51viz	352	40	of	of	IN
cord-280878-1kt51viz	352	41	SH	sh	NN
cord-280878-1kt51viz	352	42	protein	protein	NN
cord-280878-1kt51viz	352	43	has	have	VBZ
cord-280878-1kt51viz	352	44	been	be	VBN
cord-280878-1kt51viz	352	45	observed	observe	VBN
cord-280878-1kt51viz	352	46	for	for	IN
cord-280878-1kt51viz	352	47	other	other	JJ
cord-280878-1kt51viz	352	48	members	member	NNS
cord-280878-1kt51viz	352	49	of	of	IN
cord-280878-1kt51viz	352	50	the	the	DT
cord-280878-1kt51viz	352	51	Paramyxoviridae	Paramyxoviridae	NNP
cord-280878-1kt51viz	352	52	family	family	NN
cord-280878-1kt51viz	352	53	,	,	,
cord-280878-1kt51viz	352	54	eg	eg	XX
cord-280878-1kt51viz	352	55	,	,	,
cord-280878-1kt51viz	352	56	J	J	NNP
cord-280878-1kt51viz	352	57	Paramyxovirus	Paramyxovirus	NNP
cord-280878-1kt51viz	352	58	(	(	-LRB-
cord-280878-1kt51viz	352	59	JPV	JPV	NNP
cord-280878-1kt51viz	352	60	)	)	-RRB-
cord-280878-1kt51viz	352	61	(	(	-LRB-
cord-280878-1kt51viz	352	62	Jack	Jack	NNP
cord-280878-1kt51viz	352	63	,	,	,
cord-280878-1kt51viz	352	64	Boyle	Boyle	NNP
cord-280878-1kt51viz	352	65	,	,	,
cord-280878-1kt51viz	352	66	Eaton	Eaton	NNP
cord-280878-1kt51viz	352	67	,	,	,
cord-280878-1kt51viz	352	68	&	&	CC
cord-280878-1kt51viz	352	69	Wang	Wang	NNP
cord-280878-1kt51viz	352	70	,	,	,
cord-280878-1kt51viz	352	71	2005	2005	CD
cord-280878-1kt51viz	352	72	;	;	:
cord-280878-1kt51viz	352	73	Li	Li	NNP
cord-280878-1kt51viz	352	74	et	et	NNP
cord-280878-1kt51viz	352	75	al	al	NNP
cord-280878-1kt51viz	352	76	.	.	NNP
cord-280878-1kt51viz	352	77	,	,	,
cord-280878-1kt51viz	352	78	2011	2011	CD
cord-280878-1kt51viz	352	79	)	)	-RRB-
cord-280878-1kt51viz	352	80	,	,	,
cord-280878-1kt51viz	352	81	mumps	mumps	NN
cord-280878-1kt51viz	352	82	virus	virus	NN
cord-280878-1kt51viz	352	83	(	(	-LRB-
cord-280878-1kt51viz	352	84	MuV	MuV	NNP
cord-280878-1kt51viz	352	85	)	)	-RRB-
cord-280878-1kt51viz	352	86	,	,	,
cord-280878-1kt51viz	352	87	and	and	CC
cord-280878-1kt51viz	352	88	the	the	DT
cord-280878-1kt51viz	352	89	parainfluenza	parainfluenza	NNP
cord-280878-1kt51viz	352	90	virus	virus	NNP
cord-280878-1kt51viz	352	91	5	5	CD
cord-280878-1kt51viz	352	92	(	(	-LRB-
cord-280878-1kt51viz	352	93	PIV5	PIV5	NNP
cord-280878-1kt51viz	352	94	)	)	-RRB-
cord-280878-1kt51viz	352	95	,	,	,
cord-280878-1kt51viz	352	96	formerly	formerly	RB
cord-280878-1kt51viz	352	97	known	know	VBN
cord-280878-1kt51viz	352	98	as	as	IN
cord-280878-1kt51viz	352	99	simian	simian	JJ
cord-280878-1kt51viz	352	100	virus	virus	NN
cord-280878-1kt51viz	352	101	5	5	CD
cord-280878-1kt51viz	352	102	(	(	-LRB-
cord-280878-1kt51viz	352	103	SV5	SV5	NNP
cord-280878-1kt51viz	352	104	)	)	-RRB-
cord-280878-1kt51viz	352	105	.	.	.
cord-280878-1kt51viz	353	1	In	in	IN
cord-280878-1kt51viz	353	2	all	all	PDT
cord-280878-1kt51viz	353	3	these	these	DT
cord-280878-1kt51viz	353	4	systems	system	NNS
cord-280878-1kt51viz	353	5	,	,	,
cord-280878-1kt51viz	353	6	the	the	DT
cord-280878-1kt51viz	353	7	SH	SH	NNP
cord-280878-1kt51viz	353	8	protein	protein	NN
cord-280878-1kt51viz	353	9	seems	seem	VBZ
cord-280878-1kt51viz	353	10	to	to	TO
cord-280878-1kt51viz	353	11	block	block	VB
cord-280878-1kt51viz	353	12	apoptosis	apoptosis	NN
cord-280878-1kt51viz	353	13	during	during	IN
cord-280878-1kt51viz	353	14	infection	infection	NN
cord-280878-1kt51viz	353	15	-	-	:
cord-280878-1kt51viz	353	16	at	at	IN
cord-280878-1kt51viz	353	17	least	least	JJS
cord-280878-1kt51viz	353	18	in	in	IN
cord-280878-1kt51viz	353	19	part	part	NN
cord-280878-1kt51viz	353	20	-	-	HYPH
cord-280878-1kt51viz	353	21	through	through	RP
cord-280878-1kt51viz	353	22	inhibition	inhibition	NN
cord-280878-1kt51viz	353	23	of	of	IN
cord-280878-1kt51viz	353	24	the	the	DT
cord-280878-1kt51viz	353	25	TNF	TNF	NNP
cord-280878-1kt51viz	353	26	-	-	HYPH
cord-280878-1kt51viz	353	27	α	α	NNP
cord-280878-1kt51viz	353	28	pathway	pathway	NN
cord-280878-1kt51viz	353	29	(	(	-LRB-
cord-280878-1kt51viz	353	30	Fuentes	Fuentes	NNPS
cord-280878-1kt51viz	353	31	et	et	NNP
cord-280878-1kt51viz	353	32	al	al	NNP
cord-280878-1kt51viz	353	33	.	.	NNP
cord-280878-1kt51viz	353	34	,	,	,
cord-280878-1kt51viz	353	35	2007	2007	CD
cord-280878-1kt51viz	353	36	;	;	:
cord-280878-1kt51viz	353	37	Li	Li	NNP
cord-280878-1kt51viz	353	38	et	et	NNP
cord-280878-1kt51viz	353	39	al	al	NNP
cord-280878-1kt51viz	353	40	.	.	NNP
cord-280878-1kt51viz	353	41	,	,	,
cord-280878-1kt51viz	353	42	2011	2011	CD
cord-280878-1kt51viz	353	43	;	;	:
cord-280878-1kt51viz	353	44	Lin	Lin	NNP
cord-280878-1kt51viz	353	45	,	,	,
cord-280878-1kt51viz	353	46	Bright	Bright	NNP
cord-280878-1kt51viz	353	47	,	,	,
cord-280878-1kt51viz	353	48	Rothermel	Rothermel	NNP
cord-280878-1kt51viz	353	49	,	,	,
cord-280878-1kt51viz	353	50	&	&	CC
cord-280878-1kt51viz	353	51	He	He	NNP
cord-280878-1kt51viz	353	52	,	,	,
cord-280878-1kt51viz	353	53	2003	2003	CD
cord-280878-1kt51viz	353	54	;	;	:
cord-280878-1kt51viz	353	55	Wilson	Wilson	NNP
cord-280878-1kt51viz	353	56	,	,	,
cord-280878-1kt51viz	353	57	Fuentes	Fuentes	NNPS
cord-280878-1kt51viz	353	58	,	,	,
cord-280878-1kt51viz	353	59	et	et	NNP
cord-280878-1kt51viz	353	60	al	al	NNP
cord-280878-1kt51viz	353	61	.	.	NNP
cord-280878-1kt51viz	353	62	,	,	,
cord-280878-1kt51viz	353	63	2006	2006	CD
cord-280878-1kt51viz	353	64	)	)	-RRB-
cord-280878-1kt51viz	353	65	.	.	.
cord-280878-1kt51viz	354	1	The	the	DT
cord-280878-1kt51viz	354	2	mutual	mutual	JJ
cord-280878-1kt51viz	354	3	orientation	orientation	NN
cord-280878-1kt51viz	354	4	of	of	IN
cord-280878-1kt51viz	354	5	the	the	DT
cord-280878-1kt51viz	354	6	TM	TM	NNP
cord-280878-1kt51viz	354	7	α	α	NN
cord-280878-1kt51viz	354	8	-	-	:
cord-280878-1kt51viz	354	9	helices	helix	NNS
cord-280878-1kt51viz	354	10	that	that	WDT
cord-280878-1kt51viz	354	11	form	form	VBP
cord-280878-1kt51viz	354	12	the	the	DT
cord-280878-1kt51viz	354	13	ion	ion	NN
cord-280878-1kt51viz	354	14	channel	channel	NN
cord-280878-1kt51viz	354	15	was	be	VBD
cord-280878-1kt51viz	354	16	determined	determine	VBN
cord-280878-1kt51viz	354	17	in	in	IN
cord-280878-1kt51viz	354	18	lipid	lipid	NN
cord-280878-1kt51viz	354	19	bilayers	bilayer	NNS
cord-280878-1kt51viz	354	20	using	use	VBG
cord-280878-1kt51viz	354	21	site	site	NN
cord-280878-1kt51viz	354	22	-	-	HYPH
cord-280878-1kt51viz	354	23	specific	specific	JJ
cord-280878-1kt51viz	354	24	infrared	infrared	JJ
cord-280878-1kt51viz	354	25	dichroism	dichroism	NN
cord-280878-1kt51viz	354	26	(	(	-LRB-
cord-280878-1kt51viz	354	27	Gan	Gan	NNP
cord-280878-1kt51viz	354	28	,	,	,
cord-280878-1kt51viz	354	29	Ng	Ng	NNP
cord-280878-1kt51viz	354	30	,	,	,
cord-280878-1kt51viz	354	31	Xin	Xin	NNP
cord-280878-1kt51viz	354	32	,	,	,
cord-280878-1kt51viz	354	33	Gong	Gong	NNP
cord-280878-1kt51viz	354	34	,	,	,
cord-280878-1kt51viz	354	35	&	&	CC
cord-280878-1kt51viz	354	36	Torres	Torres	NNP
cord-280878-1kt51viz	354	37	,	,	,
cord-280878-1kt51viz	354	38	2008	2008	CD
cord-280878-1kt51viz	354	39	)	)	-RRB-
cord-280878-1kt51viz	354	40	.	.	.
cord-280878-1kt51viz	355	1	A	a	DT
cord-280878-1kt51viz	355	2	description	description	NN
cord-280878-1kt51viz	355	3	of	of	IN
cord-280878-1kt51viz	355	4	the	the	DT
cord-280878-1kt51viz	355	5	full	full	JJ
cord-280878-1kt51viz	355	6	-	-	HYPH
cord-280878-1kt51viz	355	7	length	length	NN
cord-280878-1kt51viz	355	8	RSV	RSV	NNP
cord-280878-1kt51viz	355	9	SH	SH	NNP
cord-280878-1kt51viz	355	10	protein	protein	NN
cord-280878-1kt51viz	355	11	monomer	monomer	NN
cord-280878-1kt51viz	355	12	has	have	VBZ
cord-280878-1kt51viz	355	13	been	be	VBN
cord-280878-1kt51viz	355	14	obtained	obtain	VBN
cord-280878-1kt51viz	355	15	by	by	IN
cord-280878-1kt51viz	355	16	solution	solution	NN
cord-280878-1kt51viz	355	17	NMR	NMR	NNP
cord-280878-1kt51viz	355	18	in	in	IN
cord-280878-1kt51viz	355	19	DPC	DPC	NNP
cord-280878-1kt51viz	355	20	micelles	micelle	NNS
cord-280878-1kt51viz	355	21	(	(	-LRB-
cord-280878-1kt51viz	355	22	Gan	Gan	NNP
cord-280878-1kt51viz	355	23	et	et	FW
cord-280878-1kt51viz	355	24	al	al	NNP
cord-280878-1kt51viz	355	25	.	.	NNP
cord-280878-1kt51viz	355	26	,	,	,
cord-280878-1kt51viz	355	27	2012	2012	CD
cord-280878-1kt51viz	355	28	)	)	-RRB-
cord-280878-1kt51viz	355	29	and	and	CC
cord-280878-1kt51viz	355	30	later	later	RB
cord-280878-1kt51viz	355	31	in	in	IN
cord-280878-1kt51viz	355	32	bicelles	bicelle	NNS
cord-280878-1kt51viz	355	33	,	,	,
cord-280878-1kt51viz	355	34	only	only	RB
cord-280878-1kt51viz	355	35	for	for	IN
cord-280878-1kt51viz	355	36	the	the	DT
cord-280878-1kt51viz	355	37	extramembrane	extramembrane	NNP
cord-280878-1kt51viz	355	38	domains	domain	NNS
cord-280878-1kt51viz	355	39	.	.	.
cord-280878-1kt51viz	356	1	Like	like	IN
cord-280878-1kt51viz	356	2	SARS	SARS	NNP
cord-280878-1kt51viz	356	3	-	-	HYPH
cord-280878-1kt51viz	356	4	CoV	CoV	NNP
cord-280878-1kt51viz	356	5	E	E	NNP
cord-280878-1kt51viz	356	6	,	,	,
cord-280878-1kt51viz	356	7	the	the	DT
cord-280878-1kt51viz	356	8	RSV	RSV	NNP
cord-280878-1kt51viz	356	9	SH	SH	NNP
cord-280878-1kt51viz	356	10	protein	protein	NN
cord-280878-1kt51viz	356	11	forms	form	NNS
cord-280878-1kt51viz	356	12	homopentameric	homopentameric	JJ
cord-280878-1kt51viz	356	13	channels	channel	NNS
cord-280878-1kt51viz	356	14	(	(	-LRB-
cord-280878-1kt51viz	356	15	Gan	Gan	NNP
cord-280878-1kt51viz	356	16	et	et	FW
cord-280878-1kt51viz	356	17	al	al	NNP
cord-280878-1kt51viz	356	18	.	.	NNP
cord-280878-1kt51viz	356	19	,	,	,
cord-280878-1kt51viz	356	20	2008	2008	CD
cord-280878-1kt51viz	357	1	(	(	-LRB-
cord-280878-1kt51viz	357	2	Gan	Gan	NNP
cord-280878-1kt51viz	357	3	et	et	FW
cord-280878-1kt51viz	357	4	al	al	NNP
cord-280878-1kt51viz	357	5	.	.	.
cord-280878-1kt51viz	358	1	,	,	,
cord-280878-1kt51viz	358	2	,	,	,
cord-280878-1kt51viz	358	3	2012	2012	CD
cord-280878-1kt51viz	358	4	that	that	WDT
cord-280878-1kt51viz	358	5	have	have	VBP
cord-280878-1kt51viz	358	6	low	low	JJ
cord-280878-1kt51viz	358	7	ion	ion	NN
cord-280878-1kt51viz	358	8	selectivity	selectivity	NN
cord-280878-1kt51viz	358	9	.	.	.
cord-280878-1kt51viz	359	1	The	the	DT
cord-280878-1kt51viz	359	2	TM	TM	NNP
cord-280878-1kt51viz	359	3	domain	domain	NN
cord-280878-1kt51viz	359	4	of	of	IN
cord-280878-1kt51viz	359	5	SH	sh	NN
cord-280878-1kt51viz	359	6	protein	protein	NN
cord-280878-1kt51viz	359	7	has	have	VBZ
cord-280878-1kt51viz	359	8	a	a	DT
cord-280878-1kt51viz	359	9	funnel	funnel	NN
cord-280878-1kt51viz	359	10	-	-	HYPH
cord-280878-1kt51viz	359	11	like	like	JJ
cord-280878-1kt51viz	359	12	architecture	architecture	NN
cord-280878-1kt51viz	360	1	(	(	-LRB-
cord-280878-1kt51viz	360	2	Gan	Gan	NNP
cord-280878-1kt51viz	360	3	et	et	NNP
cord-280878-1kt51viz	360	4	al	al	NNP
cord-280878-1kt51viz	360	5	.	.	NNP
cord-280878-1kt51viz	360	6	,	,	,
cord-280878-1kt51viz	360	7	2012	2012	CD
cord-280878-1kt51viz	360	8	)	)	-RRB-
cord-280878-1kt51viz	360	9	,	,	,
cord-280878-1kt51viz	360	10	as	as	IN
cord-280878-1kt51viz	360	11	observed	observe	VBN
cord-280878-1kt51viz	360	12	in	in	IN
cord-280878-1kt51viz	360	13	other	other	JJ
cord-280878-1kt51viz	360	14	viroporins	viroporin	NNS
cord-280878-1kt51viz	360	15	,	,	,
cord-280878-1kt51viz	361	1	eg	eg	UH
cord-280878-1kt51viz	361	2	,	,	,
cord-280878-1kt51viz	361	3	the	the	DT
cord-280878-1kt51viz	361	4	IAV	IAV	NNP
cord-280878-1kt51viz	361	5	M2	M2	NNP
cord-280878-1kt51viz	361	6	(	(	-LRB-
cord-280878-1kt51viz	361	7	Schnell	Schnell	NNP
cord-280878-1kt51viz	361	8	&	&	CC
cord-280878-1kt51viz	361	9	Chou	Chou	NNP
cord-280878-1kt51viz	361	10	,	,	,
cord-280878-1kt51viz	361	11	2008	2008	CD
cord-280878-1kt51viz	361	12	)	)	-RRB-
cord-280878-1kt51viz	361	13	,	,	,
cord-280878-1kt51viz	361	14	SARS	SARS	NNP
cord-280878-1kt51viz	361	15	-	-	HYPH
cord-280878-1kt51viz	361	16	CoV	CoV	NNP
cord-280878-1kt51viz	361	17	E	E	NNP
cord-280878-1kt51viz	361	18	(	(	-LRB-
cord-280878-1kt51viz	361	19	Pervushin	Pervushin	NNP
cord-280878-1kt51viz	361	20	et	et	FW
cord-280878-1kt51viz	361	21	al	al	NNP
cord-280878-1kt51viz	361	22	.	.	NNP
cord-280878-1kt51viz	361	23	,	,	,
cord-280878-1kt51viz	361	24	2009	2009	CD
cord-280878-1kt51viz	361	25	)	)	-RRB-
cord-280878-1kt51viz	361	26	and	and	CC
cord-280878-1kt51viz	361	27	HCV	HCV	NNP
cord-280878-1kt51viz	361	28	p7	p7	NNP
cord-280878-1kt51viz	361	29	(	(	-LRB-
cord-280878-1kt51viz	361	30	Ouyang	Ouyang	NNP
cord-280878-1kt51viz	361	31	et	et	NNP
cord-280878-1kt51viz	361	32	al	al	NNP
cord-280878-1kt51viz	361	33	.	.	NNP
cord-280878-1kt51viz	361	34	,	,	,
cord-280878-1kt51viz	361	35	2013	2013	CD
cord-280878-1kt51viz	361	36	)	)	-RRB-
cord-280878-1kt51viz	361	37	.	.	.
cord-280878-1kt51viz	362	1	A	a	DT
cord-280878-1kt51viz	362	2	narrower	narrow	JJR
cord-280878-1kt51viz	362	3	region	region	NN
cord-280878-1kt51viz	362	4	(	(	-LRB-
cord-280878-1kt51viz	362	5	Gan	Gan	NNP
cord-280878-1kt51viz	362	6	et	et	FW
cord-280878-1kt51viz	362	7	al	al	NNP
cord-280878-1kt51viz	362	8	.	.	NNP
cord-280878-1kt51viz	362	9	,	,	,
cord-280878-1kt51viz	362	10	2012	2012	CD
cord-280878-1kt51viz	362	11	)	)	-RRB-
cord-280878-1kt51viz	362	12	in	in	IN
cord-280878-1kt51viz	362	13	the	the	DT
cord-280878-1kt51viz	362	14	TM	TM	NNP
cord-280878-1kt51viz	362	15	domain	domain	NN
cord-280878-1kt51viz	362	16	is	be	VBZ
cord-280878-1kt51viz	362	17	lined	line	VBN
cord-280878-1kt51viz	362	18	with	with	IN
cord-280878-1kt51viz	362	19	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	362	20	side	side	NN
cord-280878-1kt51viz	362	21	chains	chain	NNS
cord-280878-1kt51viz	362	22	whereas	whereas	IN
cord-280878-1kt51viz	362	23	the	the	DT
cord-280878-1kt51viz	362	24	more	more	RBR
cord-280878-1kt51viz	362	25	open	open	JJ
cord-280878-1kt51viz	362	26	N	n	CD
cord-280878-1kt51viz	362	27	-	-	HYPH
cord-280878-1kt51viz	362	28	terminal	terminal	NN
cord-280878-1kt51viz	362	29	region	region	NN
cord-280878-1kt51viz	362	30	is	be	VBZ
cord-280878-1kt51viz	362	31	lined	line	VBN
cord-280878-1kt51viz	362	32	by	by	IN
cord-280878-1kt51viz	362	33	polar	polar	JJ
cord-280878-1kt51viz	362	34	residues	residue	NNS
cord-280878-1kt51viz	362	35	,	,	,
cord-280878-1kt51viz	362	36	ie	ie	NNS
cord-280878-1kt51viz	362	37	,	,	,
cord-280878-1kt51viz	362	38	His-22	His-22	NNP
cord-280878-1kt51viz	362	39	,	,	,
cord-280878-1kt51viz	362	40	Thr-25	Thr-25	NNP
cord-280878-1kt51viz	362	41	,	,	,
cord-280878-1kt51viz	362	42	and	and	CC
cord-280878-1kt51viz	362	43	Ser-29	Ser-29	NNP
cord-280878-1kt51viz	362	44	.	.	.
cord-280878-1kt51viz	363	1	The	the	DT
cord-280878-1kt51viz	363	2	TM	TM	NNP
cord-280878-1kt51viz	363	3	α	α	NN
cord-280878-1kt51viz	363	4	-	-	HYPH
cord-280878-1kt51viz	363	5	helix	helix	NN
cord-280878-1kt51viz	363	6	extends	extend	VBZ
cord-280878-1kt51viz	363	7	up	up	IN
cord-280878-1kt51viz	363	8	to	to	IN
cord-280878-1kt51viz	363	9	His-51	His-51	NNP
cord-280878-1kt51viz	363	10	in	in	IN
cord-280878-1kt51viz	363	11	the	the	DT
cord-280878-1kt51viz	363	12	C	c	NN
cord-280878-1kt51viz	363	13	-	-	HYPH
cord-280878-1kt51viz	363	14	terminal	terminal	NN
cord-280878-1kt51viz	363	15	region	region	NN
cord-280878-1kt51viz	363	16	,	,	,
cord-280878-1kt51viz	363	17	followed	follow	VBN
cord-280878-1kt51viz	363	18	by	by	IN
cord-280878-1kt51viz	363	19	a	a	DT
cord-280878-1kt51viz	363	20	loop	loop	NN
cord-280878-1kt51viz	363	21	,	,	,
cord-280878-1kt51viz	363	22	whereas	whereas	IN
cord-280878-1kt51viz	363	23	the	the	DT
cord-280878-1kt51viz	363	24	N	n	CD
cord-280878-1kt51viz	363	25	-	-	HYPH
cord-280878-1kt51viz	363	26	terminal	terminal	JJ
cord-280878-1kt51viz	363	27	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	363	28	extramembrane	extramembrane	NNP
cord-280878-1kt51viz	363	29	domain	domain	NNP
cord-280878-1kt51viz	363	30	forms	form	VBZ
cord-280878-1kt51viz	363	31	a	a	DT
cord-280878-1kt51viz	363	32	short	short	JJ
cord-280878-1kt51viz	363	33	α	α	NN
cord-280878-1kt51viz	363	34	-	-	HYPH
cord-280878-1kt51viz	363	35	helix	helix	NN
cord-280878-1kt51viz	363	36	(	(	-LRB-
cord-280878-1kt51viz	363	37	residues	residue	NNS
cord-280878-1kt51viz	363	38	5	5	CD
cord-280878-1kt51viz	363	39	-	-	SYM
cord-280878-1kt51viz	363	40	14	14	CD
cord-280878-1kt51viz	363	41	)	)	-RRB-
cord-280878-1kt51viz	364	1	present	present	JJ
cord-280878-1kt51viz	364	2	both	both	CC
cord-280878-1kt51viz	364	3	in	in	IN
cord-280878-1kt51viz	364	4	micelles	micelle	NNS
cord-280878-1kt51viz	364	5	and	and	CC
cord-280878-1kt51viz	364	6	in	in	IN
cord-280878-1kt51viz	364	7	bicelles	bicelle	NNS
cord-280878-1kt51viz	364	8	.	.	.
cord-280878-1kt51viz	365	1	Only	only	RB
cord-280878-1kt51viz	365	2	one	one	CD
cord-280878-1kt51viz	365	3	compound	compound	NN
cord-280878-1kt51viz	365	4	,	,	,
cord-280878-1kt51viz	365	5	pyronin	pyronin	NN
cord-280878-1kt51viz	365	6	-	-	HYPH
cord-280878-1kt51viz	365	7	B	B	NNP
cord-280878-1kt51viz	365	8	,	,	,
cord-280878-1kt51viz	365	9	has	have	VBZ
cord-280878-1kt51viz	365	10	been	be	VBN
cord-280878-1kt51viz	365	11	reported	report	VBN
cord-280878-1kt51viz	365	12	to	to	TO
cord-280878-1kt51viz	365	13	inhibit	inhibit	VB
cord-280878-1kt51viz	365	14	the	the	DT
cord-280878-1kt51viz	365	15	channel	channel	NN
cord-280878-1kt51viz	365	16	activity	activity	NN
cord-280878-1kt51viz	365	17	of	of	IN
cord-280878-1kt51viz	365	18	the	the	DT
cord-280878-1kt51viz	365	19	SH	SH	NNP
cord-280878-1kt51viz	365	20	protein	protein	NN
cord-280878-1kt51viz	365	21	.	.	.
cord-280878-1kt51viz	366	1	This	this	DT
cord-280878-1kt51viz	366	2	compound	compound	NN
cord-280878-1kt51viz	366	3	was	be	VBD
cord-280878-1kt51viz	366	4	obtained	obtain	VBN
cord-280878-1kt51viz	366	5	from	from	IN
cord-280878-1kt51viz	366	6	liposome	liposome	NN
cord-280878-1kt51viz	366	7	-	-	HYPH
cord-280878-1kt51viz	366	8	based	base	VBN
cord-280878-1kt51viz	366	9	fluorescence	fluorescence	NN
cord-280878-1kt51viz	366	10	assay	assay	NN
cord-280878-1kt51viz	366	11	,	,	,
cord-280878-1kt51viz	366	12	and	and	CC
cord-280878-1kt51viz	366	13	was	be	VBD
cord-280878-1kt51viz	366	14	tested	test	VBN
cord-280878-1kt51viz	366	15	against	against	IN
cord-280878-1kt51viz	366	16	purified	purify	VBN
cord-280878-1kt51viz	366	17	SH	SH	NNP
cord-280878-1kt51viz	366	18	protein	protein	NN
cord-280878-1kt51viz	366	19	reconstituted	reconstitute	VBN
cord-280878-1kt51viz	366	20	in	in	IN
cord-280878-1kt51viz	366	21	planar	planar	JJ
cord-280878-1kt51viz	366	22	lipid	lipid	NN
cord-280878-1kt51viz	366	23	bilayers	bilayer	NNS
cord-280878-1kt51viz	366	24	(	(	-LRB-
cord-280878-1kt51viz	366	25	BLM	BLM	NNP
cord-280878-1kt51viz	366	26	)	)	-RRB-
cord-280878-1kt51viz	366	27	.	.	.
cord-280878-1kt51viz	367	1	A	a	DT
cord-280878-1kt51viz	367	2	concentration	concentration	NN
cord-280878-1kt51viz	367	3	of	of	IN
cord-280878-1kt51viz	367	4	10	10	CD
cord-280878-1kt51viz	367	5	μM	μm	NN
cord-280878-1kt51viz	367	6	led	lead	VBD
cord-280878-1kt51viz	367	7	to	to	IN
cord-280878-1kt51viz	367	8	a	a	DT
cord-280878-1kt51viz	367	9	$	$	$
cord-280878-1kt51viz	367	10	60	60	CD
cord-280878-1kt51viz	367	11	%	%	NN
cord-280878-1kt51viz	367	12	inhibition	inhibition	NN
cord-280878-1kt51viz	367	13	of	of	IN
cord-280878-1kt51viz	367	14	channel	channel	NN
cord-280878-1kt51viz	367	15	activity	activity	NN
cord-280878-1kt51viz	367	16	,	,	,
cord-280878-1kt51viz	367	17	with	with	IN
cord-280878-1kt51viz	367	18	a	a	DT
cord-280878-1kt51viz	367	19	Kd	Kd	NNP
cord-280878-1kt51viz	367	20	of	of	IN
cord-280878-1kt51viz	367	21	$	$	$
cord-280878-1kt51viz	367	22	7	7	CD
cord-280878-1kt51viz	368	1	μM.	μM.	NNP
cord-280878-1kt51viz	369	1	The	the	DT
cord-280878-1kt51viz	369	2	effect	effect	NN
cord-280878-1kt51viz	369	3	of	of	IN
cord-280878-1kt51viz	369	4	pyronin	pyronin	NN
cord-280878-1kt51viz	369	5	-	-	HYPH
cord-280878-1kt51viz	369	6	B	B	NNP
cord-280878-1kt51viz	369	7	was	be	VBD
cord-280878-1kt51viz	369	8	tested	test	VBN
cord-280878-1kt51viz	369	9	against	against	IN
cord-280878-1kt51viz	369	10	RSV	RSV	NNP
cord-280878-1kt51viz	369	11	replication	replication	NN
cord-280878-1kt51viz	369	12	in	in	IN
cord-280878-1kt51viz	369	13	Vero	Vero	NNP
cord-280878-1kt51viz	369	14	cells	cell	NNS
cord-280878-1kt51viz	369	15	,	,	,
cord-280878-1kt51viz	369	16	where	where	WRB
cord-280878-1kt51viz	369	17	the	the	DT
cord-280878-1kt51viz	369	18	tissue	tissue	NN
cord-280878-1kt51viz	369	19	culture	culture	NN
cord-280878-1kt51viz	369	20	infectivity	infectivity	NN
cord-280878-1kt51viz	369	21	(	(	-LRB-
cord-280878-1kt51viz	369	22	50	50	CD
cord-280878-1kt51viz	369	23	%	%	NN
cord-280878-1kt51viz	369	24	infective	infective	JJ
cord-280878-1kt51viz	369	25	dose	dose	NN
cord-280878-1kt51viz	369	26	,	,	,
cord-280878-1kt51viz	369	27	TCID50	TCID50	NNP
cord-280878-1kt51viz	369	28	)	)	-RRB-
cord-280878-1kt51viz	369	29	was	be	VBD
cord-280878-1kt51viz	369	30	zero	zero	CD
cord-280878-1kt51viz	369	31	at	at	IN
cord-280878-1kt51viz	369	32	a	a	DT
cord-280878-1kt51viz	369	33	drug	drug	NN
cord-280878-1kt51viz	369	34	concentration	concentration	NN
cord-280878-1kt51viz	369	35	of	of	IN
cord-280878-1kt51viz	369	36	0.25	0.25	CD
cord-280878-1kt51viz	369	37	μM.	μm.	NN
cord-280878-1kt51viz	370	1	In	in	IN
cord-280878-1kt51viz	370	2	the	the	DT
cord-280878-1kt51viz	370	3	NMR	NMR	NNP
cord-280878-1kt51viz	370	4	studies	study	NNS
cord-280878-1kt51viz	370	5	,	,	,
cord-280878-1kt51viz	370	6	the	the	DT
cord-280878-1kt51viz	370	7	binding	binding	NN
cord-280878-1kt51viz	370	8	of	of	IN
cord-280878-1kt51viz	370	9	pyronin	pyronin	NN
cord-280878-1kt51viz	370	10	-	-	HYPH
cord-280878-1kt51viz	370	11	B	b	NN
cord-280878-1kt51viz	370	12	to	to	IN
cord-280878-1kt51viz	370	13	the	the	DT
cord-280878-1kt51viz	370	14	SH	SH	NNP
cord-280878-1kt51viz	370	15	protein	protein	NN
cord-280878-1kt51viz	370	16	revealed	reveal	VBD
cord-280878-1kt51viz	370	17	backbone	backbone	NN
cord-280878-1kt51viz	370	18	resonance	resonance	NN
cord-280878-1kt51viz	370	19	perturbations	perturbation	NNS
cord-280878-1kt51viz	370	20	at	at	IN
cord-280878-1kt51viz	370	21	both	both	DT
cord-280878-1kt51viz	370	22	ends	end	NNS
cord-280878-1kt51viz	370	23	of	of	IN
cord-280878-1kt51viz	370	24	the	the	DT
cord-280878-1kt51viz	370	25	TM	TM	NNP
cord-280878-1kt51viz	370	26	domain	domain	NN
cord-280878-1kt51viz	370	27	.	.	.
cord-280878-1kt51viz	371	1	At	at	IN
cord-280878-1kt51viz	371	2	the	the	DT
cord-280878-1kt51viz	371	3	N	n	CD
cord-280878-1kt51viz	371	4	-	-	HYPH
cord-280878-1kt51viz	371	5	terminal	terminal	JJ
cord-280878-1kt51viz	371	6	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	371	7	end	end	NN
cord-280878-1kt51viz	371	8	,	,	,
cord-280878-1kt51viz	371	9	residues	residue	NNS
cord-280878-1kt51viz	371	10	more	more	RBR
cord-280878-1kt51viz	371	11	affected	affected	JJ
cord-280878-1kt51viz	371	12	were	be	VBD
cord-280878-1kt51viz	372	1	Ile-6	Ile-6	NNP
cord-280878-1kt51viz	372	2	and	and	CC
cord-280878-1kt51viz	372	3	Ile-21	Ile-21	NNP
cord-280878-1kt51viz	372	4	.	.	.
cord-280878-1kt51viz	373	1	At	at	IN
cord-280878-1kt51viz	373	2	the	the	DT
cord-280878-1kt51viz	373	3	lumenal	lumenal	NNP
cord-280878-1kt51viz	373	4	C	C	NNP
cord-280878-1kt51viz	373	5	-	-	HYPH
cord-280878-1kt51viz	373	6	terminal	terminal	NN
cord-280878-1kt51viz	373	7	end	end	NN
cord-280878-1kt51viz	373	8	,	,	,
cord-280878-1kt51viz	373	9	the	the	DT
cord-280878-1kt51viz	373	10	residue	residue	NN
cord-280878-1kt51viz	373	11	most	most	RBS
cord-280878-1kt51viz	373	12	affected	affect	VBN
cord-280878-1kt51viz	373	13	was	be	VBD
cord-280878-1kt51viz	373	14	Ala-39	Ala-39	NNP
cord-280878-1kt51viz	373	15	,	,	,
cord-280878-1kt51viz	373	16	and	and	CC
cord-280878-1kt51viz	373	17	a	a	DT
cord-280878-1kt51viz	373	18	group	group	NN
cord-280878-1kt51viz	373	19	of	of	IN
cord-280878-1kt51viz	373	20	nearby	nearby	JJ
cord-280878-1kt51viz	373	21	residues	residue	NNS
cord-280878-1kt51viz	373	22	,	,	,
cord-280878-1kt51viz	373	23	Ile-38	Ile-38	NNP
cord-280878-1kt51viz	373	24	,	,	,
cord-280878-1kt51viz	373	25	Ile-40	Ile-40	NNP
cord-280878-1kt51viz	373	26	,	,	,
cord-280878-1kt51viz	373	27	Leu-41	Leu-41	NNP
cord-280878-1kt51viz	373	28	,	,	,
cord-280878-1kt51viz	373	29	and	and	CC
cord-280878-1kt51viz	373	30	Lys-43	Lys-43	NNP
cord-280878-1kt51viz	373	31	(	(	-LRB-
cord-280878-1kt51viz	373	32	Fig	Fig	NNP
cord-280878-1kt51viz	373	33	.	.	.
cord-280878-1kt51viz	373	34	7A	7a	NN
cord-280878-1kt51viz	373	35	)	)	-RRB-
cord-280878-1kt51viz	373	36	.	.	.
cord-280878-1kt51viz	374	1	Interestingly	interestingly	RB
cord-280878-1kt51viz	374	2	,	,	,
cord-280878-1kt51viz	374	3	most	most	JJS
cord-280878-1kt51viz	374	4	of	of	IN
cord-280878-1kt51viz	374	5	these	these	DT
cord-280878-1kt51viz	374	6	juxtamembrane	juxtamembrane	NNP
cord-280878-1kt51viz	374	7	residues	residue	NNS
cord-280878-1kt51viz	374	8	(	(	-LRB-
cord-280878-1kt51viz	374	9	residues	residue	NNS
cord-280878-1kt51viz	374	10	38	38	CD
cord-280878-1kt51viz	374	11	-	-	SYM
cord-280878-1kt51viz	374	12	43	43	CD
cord-280878-1kt51viz	374	13	)	)	-RRB-
cord-280878-1kt51viz	374	14	form	form	VBP
cord-280878-1kt51viz	374	15	a	a	DT
cord-280878-1kt51viz	374	16	conserved	conserved	JJ
cord-280878-1kt51viz	374	17	motif	motif	NN
cord-280878-1kt51viz	374	18	in	in	IN
cord-280878-1kt51viz	374	19	the	the	DT
cord-280878-1kt51viz	374	20	SH	SH	NNP
cord-280878-1kt51viz	374	21	protein	protein	NN
cord-280878-1kt51viz	374	22	"	"	''
cord-280878-1kt51viz	374	23	A	a	DT
cord-280878-1kt51viz	374	24	39	39	CD
cord-280878-1kt51viz	374	25	ILNKL	ILNKL	NNP
cord-280878-1kt51viz	374	26	43	43	CD
cord-280878-1kt51viz	374	27	,	,	,
cord-280878-1kt51viz	374	28	"	"	''
cord-280878-1kt51viz	374	29	which	which	WDT
cord-280878-1kt51viz	374	30	suggests	suggest	VBZ
cord-280878-1kt51viz	374	31	that	that	IN
cord-280878-1kt51viz	374	32	this	this	DT
cord-280878-1kt51viz	374	33	is	be	VBZ
cord-280878-1kt51viz	374	34	a	a	DT
cord-280878-1kt51viz	374	35	critical	critical	JJ
cord-280878-1kt51viz	374	36	region	region	NN
cord-280878-1kt51viz	374	37	for	for	IN
cord-280878-1kt51viz	374	38	SH	sh	NN
cord-280878-1kt51viz	374	39	protein	protein	NN
cord-280878-1kt51viz	374	40	with	with	IN
cord-280878-1kt51viz	374	41	a	a	DT
cord-280878-1kt51viz	374	42	high	high	JJ
cord-280878-1kt51viz	374	43	barrier	barrier	NN
cord-280878-1kt51viz	374	44	to	to	IN
cord-280878-1kt51viz	374	45	resistance	resistance	NN
cord-280878-1kt51viz	374	46	.	.	.
cord-280878-1kt51viz	375	1	Determination	determination	NN
cord-280878-1kt51viz	375	2	of	of	IN
cord-280878-1kt51viz	375	3	intermolecular	intermolecular	JJ
cord-280878-1kt51viz	375	4	nuclear	nuclear	JJ
cord-280878-1kt51viz	375	5	Overhauser	Overhauser	NNP
cord-280878-1kt51viz	375	6	effects	effect	NNS
cord-280878-1kt51viz	375	7	(	(	-LRB-
cord-280878-1kt51viz	375	8	NOEs	no	NNS
cord-280878-1kt51viz	375	9	)	)	-RRB-
cord-280878-1kt51viz	375	10	for	for	IN
cord-280878-1kt51viz	375	11	the	the	DT
cord-280878-1kt51viz	375	12	drug	drug	NN
cord-280878-1kt51viz	375	13	-	-	HYPH
cord-280878-1kt51viz	375	14	protein	protein	NN
cord-280878-1kt51viz	375	15	complex	complex	NN
cord-280878-1kt51viz	375	16	was	be	VBD
cord-280878-1kt51viz	375	17	not	not	RB
cord-280878-1kt51viz	375	18	possible	possible	JJ
cord-280878-1kt51viz	375	19	,	,	,
cord-280878-1kt51viz	375	20	probably	probably	RB
cord-280878-1kt51viz	375	21	due	due	IN
cord-280878-1kt51viz	375	22	to	to	IN
cord-280878-1kt51viz	375	23	weak	weak	JJ
cord-280878-1kt51viz	375	24	interaction	interaction	NN
cord-280878-1kt51viz	375	25	.	.	.
cord-280878-1kt51viz	376	1	Docking	docking	NN
cord-280878-1kt51viz	376	2	studies	study	NNS
cord-280878-1kt51viz	376	3	of	of	IN
cord-280878-1kt51viz	376	4	pyronin	pyronin	NN
cord-280878-1kt51viz	376	5	-	-	HYPH
cord-280878-1kt51viz	376	6	B	b	NN
cord-280878-1kt51viz	376	7	to	to	IN
cord-280878-1kt51viz	376	8	the	the	DT
cord-280878-1kt51viz	376	9	SH	SH	NNP
cord-280878-1kt51viz	376	10	pentameric	pentameric	NN
cord-280878-1kt51viz	376	11	model	model	NN
cord-280878-1kt51viz	376	12	obtained	obtain	VBN
cord-280878-1kt51viz	376	13	in	in	IN
cord-280878-1kt51viz	376	14	DPC	DPC	NNP
cord-280878-1kt51viz	376	15	micelles	micelle	NNS
cord-280878-1kt51viz	377	1	(	(	-LRB-
cord-280878-1kt51viz	377	2	Gan	Gan	NNP
cord-280878-1kt51viz	377	3	et	et	NNP
cord-280878-1kt51viz	377	4	al	al	NNP
cord-280878-1kt51viz	377	5	.	.	NNP
cord-280878-1kt51viz	377	6	,	,	,
cord-280878-1kt51viz	377	7	2012	2012	CD
cord-280878-1kt51viz	377	8	)	)	-RRB-
cord-280878-1kt51viz	377	9	produced	produce	VBD
cord-280878-1kt51viz	377	10	two	two	CD
cord-280878-1kt51viz	377	11	predicted	predict	VBN
cord-280878-1kt51viz	377	12	binding	bind	VBG
cord-280878-1kt51viz	377	13	sites	site	NNS
cord-280878-1kt51viz	377	14	at	at	IN
cord-280878-1kt51viz	377	15	both	both	DT
cord-280878-1kt51viz	377	16	ends	end	NNS
cord-280878-1kt51viz	377	17	of	of	IN
cord-280878-1kt51viz	377	18	the	the	DT
cord-280878-1kt51viz	377	19	TM	TM	NNP
cord-280878-1kt51viz	377	20	domain	domain	NN
cord-280878-1kt51viz	377	21	.	.	.
cord-280878-1kt51viz	378	1	Indeed	indeed	RB
cord-280878-1kt51viz	378	2	,	,	,
cord-280878-1kt51viz	378	3	a	a	DT
cord-280878-1kt51viz	378	4	majority	majority	NN
cord-280878-1kt51viz	378	5	of	of	IN
cord-280878-1kt51viz	378	6	structures	structure	NNS
cord-280878-1kt51viz	378	7	showed	show	VBD
cord-280878-1kt51viz	378	8	the	the	DT
cord-280878-1kt51viz	378	9	drug	drug	NN
cord-280878-1kt51viz	378	10	located	locate	VBN
cord-280878-1kt51viz	378	11	near	near	IN
cord-280878-1kt51viz	378	12	residues	residue	NNS
cord-280878-1kt51viz	378	13	with	with	IN
cord-280878-1kt51viz	378	14	largest	large	JJS
cord-280878-1kt51viz	378	15	chemical	chemical	JJ
cord-280878-1kt51viz	378	16	shift	shift	NN
cord-280878-1kt51viz	378	17	perturbation	perturbation	NN
cord-280878-1kt51viz	378	18	,	,	,
cord-280878-1kt51viz	378	19	ie	ie	FW
cord-280878-1kt51viz	378	20	,	,	,
cord-280878-1kt51viz	378	21	Ile-6	Ile-6	NNP
cord-280878-1kt51viz	378	22	,	,	,
cord-280878-1kt51viz	378	23	Ile-21	Ile-21	NNP
cord-280878-1kt51viz	378	24	,	,	,
cord-280878-1kt51viz	378	25	and	and	CC
cord-280878-1kt51viz	378	26	Ala-39	Ala-39	NNP
cord-280878-1kt51viz	378	27	(	(	-LRB-
cord-280878-1kt51viz	378	28	Fig	Fig	NNP
cord-280878-1kt51viz	378	29	.	.	NNP
cord-280878-1kt51viz	378	30	7	7	CD
cord-280878-1kt51viz	378	31	)	)	-RRB-
cord-280878-1kt51viz	378	32	.	.	.
cord-280878-1kt51viz	379	1	The	the	DT
cord-280878-1kt51viz	379	2	binding	binding	NN
cord-280878-1kt51viz	379	3	site	site	NN
cord-280878-1kt51viz	379	4	near	near	IN
cord-280878-1kt51viz	379	5	the	the	DT
cord-280878-1kt51viz	379	6	N	N	NNP
cord-280878-1kt51viz	379	7	-	-	HYPH
cord-280878-1kt51viz	379	8	terminus	terminus	NN
cord-280878-1kt51viz	379	9	is	be	VBZ
cord-280878-1kt51viz	379	10	formed	form	VBN
cord-280878-1kt51viz	379	11	by	by	IN
cord-280878-1kt51viz	379	12	Phe-14	Phe-14	NNP
cord-280878-1kt51viz	379	13	,	,	,
cord-280878-1kt51viz	379	14	Ile-21	Ile-21	NNP
cord-280878-1kt51viz	379	15	in	in	IN
cord-280878-1kt51viz	379	16	one	one	CD
cord-280878-1kt51viz	379	17	monomer	monomer	NN
cord-280878-1kt51viz	379	18	(	(	-LRB-
cord-280878-1kt51viz	379	19	i	i	NN
cord-280878-1kt51viz	379	20	+	+	SYM
cord-280878-1kt51viz	379	21	1	1	CD
cord-280878-1kt51viz	379	22	)	)	-RRB-
cord-280878-1kt51viz	379	23	,	,	,
cord-280878-1kt51viz	379	24	and	and	CC
cord-280878-1kt51viz	379	25	Ile-6	Ile-6	NNP
cord-280878-1kt51viz	379	26	of	of	IN
cord-280878-1kt51viz	379	27	the	the	DT
cord-280878-1kt51viz	379	28	previous	previous	JJ
cord-280878-1kt51viz	379	29	(	(	-LRB-
cord-280878-1kt51viz	379	30	i	i	NN
cord-280878-1kt51viz	379	31	)	)	-RRB-
cord-280878-1kt51viz	379	32	monomer	monomer	NN
cord-280878-1kt51viz	379	33	.	.	.
cord-280878-1kt51viz	380	1	The	the	DT
cord-280878-1kt51viz	380	2	one	one	CD
cord-280878-1kt51viz	380	3	near	near	IN
cord-280878-1kt51viz	380	4	the	the	DT
cord-280878-1kt51viz	380	5	C	C	NNP
cord-280878-1kt51viz	380	6	-	-	HYPH
cord-280878-1kt51viz	380	7	terminus	terminus	NN
cord-280878-1kt51viz	380	8	is	be	VBZ
cord-280878-1kt51viz	380	9	formed	form	VBN
cord-280878-1kt51viz	380	10	by	by	IN
cord-280878-1kt51viz	380	11	residues	residue	NNS
cord-280878-1kt51viz	380	12	Ile-40	Ile-40	NNP
cord-280878-1kt51viz	380	13	,	,	,
cord-280878-1kt51viz	380	14	Leu-41	Leu-41	NNP
cord-280878-1kt51viz	380	15	,	,	,
cord-280878-1kt51viz	380	16	and	and	CC
cord-280878-1kt51viz	380	17	Lys-43	Lys-43	NNP
cord-280878-1kt51viz	380	18	in	in	IN
cord-280878-1kt51viz	380	19	one	one	CD
cord-280878-1kt51viz	380	20	monomer	monomer	NN
cord-280878-1kt51viz	380	21	(	(	-LRB-
cord-280878-1kt51viz	380	22	i	i	NN
cord-280878-1kt51viz	380	23	+	+	SYM
cord-280878-1kt51viz	380	24	1	1	CD
cord-280878-1kt51viz	380	25	)	)	-RRB-
cord-280878-1kt51viz	380	26	and	and	CC
cord-280878-1kt51viz	380	27	Ile-38	Ile-38	NNP
cord-280878-1kt51viz	380	28	and	and	CC
cord-280878-1kt51viz	380	29	Ala-39	ala-39	NN
cord-280878-1kt51viz	380	30	of	of	IN
cord-280878-1kt51viz	380	31	the	the	DT
cord-280878-1kt51viz	380	32	previous	previous	JJ
cord-280878-1kt51viz	380	33	(	(	-LRB-
cord-280878-1kt51viz	380	34	i	i	NN
cord-280878-1kt51viz	380	35	)	)	-RRB-
cord-280878-1kt51viz	380	36	monomer	monomer	NN
cord-280878-1kt51viz	380	37	(	(	-LRB-
cord-280878-1kt51viz	380	38	Fig	Fig	NNP
cord-280878-1kt51viz	380	39	.	.	.
cord-280878-1kt51viz	380	40	7A	7a	NN
cord-280878-1kt51viz	380	41	-	-	HYPH
cord-280878-1kt51viz	380	42	C	C	NNP
cord-280878-1kt51viz	380	43	)	)	-RRB-
cord-280878-1kt51viz	380	44	.	.	.
cord-280878-1kt51viz	381	1	Similar	similar	JJ
cord-280878-1kt51viz	381	2	"	"	``
cord-280878-1kt51viz	381	3	druggable	druggable	JJ
cord-280878-1kt51viz	381	4	pockets	pocket	NNS
cord-280878-1kt51viz	381	5	"	"	''
cord-280878-1kt51viz	381	6	on	on	IN
cord-280878-1kt51viz	381	7	the	the	DT
cord-280878-1kt51viz	381	8	SH	SH	NNP
cord-280878-1kt51viz	381	9	pentamer	pentamer	NN
cord-280878-1kt51viz	381	10	surface	surface	NN
cord-280878-1kt51viz	381	11	were	be	VBD
cord-280878-1kt51viz	381	12	identified	identify	VBN
cord-280878-1kt51viz	381	13	using	use	VBG
cord-280878-1kt51viz	381	14	DoGSiteScorer	DoGSiteScorer	NNP
cord-280878-1kt51viz	381	15	(	(	-LRB-
cord-280878-1kt51viz	381	16	Volkamer	Volkamer	NNP
cord-280878-1kt51viz	381	17	et	et	NNP
cord-280878-1kt51viz	381	18	al	al	NNP
cord-280878-1kt51viz	381	19	.	.	NNP
cord-280878-1kt51viz	381	20	,	,	,
cord-280878-1kt51viz	381	21	2012	2012	CD
cord-280878-1kt51viz	381	22	)	)	-RRB-
cord-280878-1kt51viz	382	1	(	(	-LRB-
cord-280878-1kt51viz	382	2	Fig	Fig	NNP
cord-280878-1kt51viz	382	3	.	.	.
cord-280878-1kt51viz	382	4	7D	7D	NNP
cord-280878-1kt51viz	382	5	)	)	-RRB-
cord-280878-1kt51viz	382	6	.	.	.
cord-280878-1kt51viz	383	1	However	however	RB
cord-280878-1kt51viz	383	2	,	,	,
cord-280878-1kt51viz	383	3	the	the	DT
cord-280878-1kt51viz	383	4	C	c	NN
cord-280878-1kt51viz	383	5	-	-	HYPH
cord-280878-1kt51viz	383	6	terminal	terminal	JJ
cord-280878-1kt51viz	383	7	end	end	NN
cord-280878-1kt51viz	383	8	of	of	IN
cord-280878-1kt51viz	383	9	the	the	DT
cord-280878-1kt51viz	383	10	TM	TM	NNP
cord-280878-1kt51viz	383	11	domain	domain	NN
cord-280878-1kt51viz	383	12	(	(	-LRB-
cord-280878-1kt51viz	383	13	residues	residue	NNS
cord-280878-1kt51viz	383	14	38	38	CD
cord-280878-1kt51viz	383	15	-	-	SYM
cord-280878-1kt51viz	383	16	41	41	CD
cord-280878-1kt51viz	383	17	)	)	-RRB-
cord-280878-1kt51viz	383	18	is	be	VBZ
cord-280878-1kt51viz	383	19	sufficient	sufficient	JJ
cord-280878-1kt51viz	383	20	for	for	IN
cord-280878-1kt51viz	383	21	inhibition	inhibition	NN
cord-280878-1kt51viz	383	22	,	,	,
cord-280878-1kt51viz	383	23	since	since	IN
cord-280878-1kt51viz	383	24	a	a	DT
cord-280878-1kt51viz	383	25	conservative	conservative	JJ
cord-280878-1kt51viz	383	26	mutation	mutation	NN
cord-280878-1kt51viz	383	27	A39S	A39S	.
cord-280878-1kt51viz	383	28	almost	almost	RB
cord-280878-1kt51viz	383	29	completely	completely	RB
cord-280878-1kt51viz	383	30	prevented	prevent	VBD
cord-280878-1kt51viz	383	31	inhibition	inhibition	NN
cord-280878-1kt51viz	383	32	(	(	-LRB-
cord-280878-1kt51viz	383	33	$	$	$
cord-280878-1kt51viz	383	34	10	10	CD
cord-280878-1kt51viz	383	35	%	%	NN
cord-280878-1kt51viz	383	36	inhibition	inhibition	NN
cord-280878-1kt51viz	383	37	)	)	-RRB-
cord-280878-1kt51viz	383	38	.	.	.
cord-280878-1kt51viz	384	1	Only	only	RB
cord-280878-1kt51viz	384	2	two	two	CD
cord-280878-1kt51viz	384	3	monomers	monomer	NNS
cord-280878-1kt51viz	384	4	of	of	IN
cord-280878-1kt51viz	384	5	SH	SH	NNP
cord-280878-1kt51viz	384	6	protein	protein	NN
cord-280878-1kt51viz	384	7	pentamer	pentamer	NNP
cord-280878-1kt51viz	384	8	(	(	-LRB-
cord-280878-1kt51viz	384	9	i	i	NNP
cord-280878-1kt51viz	384	10	and	and	CC
cord-280878-1kt51viz	384	11	i	i	NN
cord-280878-1kt51viz	384	12	+	+	SYM
cord-280878-1kt51viz	384	13	1	1	CD
cord-280878-1kt51viz	384	14	)	)	-RRB-
cord-280878-1kt51viz	384	15	are	be	VBP
cord-280878-1kt51viz	384	16	shown	show	VBN
cord-280878-1kt51viz	384	17	for	for	IN
cord-280878-1kt51viz	384	18	simplicity	simplicity	NN
cord-280878-1kt51viz	384	19	;	;	:
cord-280878-1kt51viz	384	20	(	(	-LRB-
cord-280878-1kt51viz	384	21	D	d	NN
cord-280878-1kt51viz	384	22	)	)	-RRB-
cord-280878-1kt51viz	384	23	druggable	druggable	JJ
cord-280878-1kt51viz	384	24	pockets	pocket	NNS
cord-280878-1kt51viz	384	25	(	(	-LRB-
cord-280878-1kt51viz	384	26	green	green	JJ
cord-280878-1kt51viz	384	27	(	(	-LRB-
cord-280878-1kt51viz	384	28	dark	dark	JJ
cord-280878-1kt51viz	384	29	gray	gray	NN
cord-280878-1kt51viz	384	30	in	in	IN
cord-280878-1kt51viz	384	31	the	the	DT
cord-280878-1kt51viz	384	32	print	print	NN
cord-280878-1kt51viz	384	33	version	version	NN
cord-280878-1kt51viz	384	34	)	)	-RRB-
cord-280878-1kt51viz	384	35	mesh	mesh	NN
cord-280878-1kt51viz	384	36	)	)	-RRB-
cord-280878-1kt51viz	384	37	predicted	predict	VBN
cord-280878-1kt51viz	384	38	by	by	IN
cord-280878-1kt51viz	384	39	DoGSiteScorer	DoGSiteScorer	NNP
cord-280878-1kt51viz	384	40	(	(	-LRB-
cord-280878-1kt51viz	384	41	Volkamer	Volkamer	NNP
cord-280878-1kt51viz	384	42	,	,	,
cord-280878-1kt51viz	384	43	Kuhn	Kuhn	NNP
cord-280878-1kt51viz	384	44	,	,	,
cord-280878-1kt51viz	384	45	Rippmann	Rippmann	NNP
cord-280878-1kt51viz	384	46	,	,	,
cord-280878-1kt51viz	384	47	&	&	CC
cord-280878-1kt51viz	384	48	Rarey	Rarey	NNP
cord-280878-1kt51viz	384	49	,	,	,
cord-280878-1kt51viz	384	50	2012	2012	CD
cord-280878-1kt51viz	384	51	)	)	-RRB-
cord-280878-1kt51viz	384	52	.	.	.
cord-280878-1kt51viz	385	1	The	the	DT
cord-280878-1kt51viz	385	2	main	main	JJ
cord-280878-1kt51viz	385	3	residues	residue	NNS
cord-280878-1kt51viz	385	4	that	that	WDT
cord-280878-1kt51viz	385	5	showed	show	VBD
cord-280878-1kt51viz	385	6	largest	large	JJS
cord-280878-1kt51viz	385	7	NMR	NMR	NNP
cord-280878-1kt51viz	385	8	chemical	chemical	NN
cord-280878-1kt51viz	385	9	shift	shift	NN
cord-280878-1kt51viz	385	10	changes	change	NNS
cord-280878-1kt51viz	385	11	are	be	VBP
cord-280878-1kt51viz	385	12	shown	show	VBN
cord-280878-1kt51viz	385	13	in	in	IN
cord-280878-1kt51viz	385	14	red	red	JJ
cord-280878-1kt51viz	385	15	(	(	-LRB-
cord-280878-1kt51viz	385	16	dark	dark	JJ
cord-280878-1kt51viz	385	17	gray	gray	NN
cord-280878-1kt51viz	385	18	in	in	IN
cord-280878-1kt51viz	385	19	the	the	DT
cord-280878-1kt51viz	385	20	print	print	NN
cord-280878-1kt51viz	385	21	version	version	NN
cord-280878-1kt51viz	385	22	)	)	-RRB-
cord-280878-1kt51viz	385	23	.	.	.
cord-280878-1kt51viz	386	1	Two	two	CD
cord-280878-1kt51viz	386	2	monomers	monomer	NNS
cord-280878-1kt51viz	386	3	have	have	VBP
cord-280878-1kt51viz	386	4	been	be	VBN
cord-280878-1kt51viz	386	5	removed	remove	VBN
cord-280878-1kt51viz	386	6	from	from	IN
cord-280878-1kt51viz	386	7	the	the	DT
cord-280878-1kt51viz	386	8	pentamer	pentamer	NNP
cord-280878-1kt51viz	386	9	for	for	IN
cord-280878-1kt51viz	386	10	clarity	clarity	NN
cord-280878-1kt51viz	386	11	.	.	.
cord-280878-1kt51viz	387	1	Vpu	Vpu	NNP
cord-280878-1kt51viz	387	2	is	be	VBZ
cord-280878-1kt51viz	387	3	a	a	DT
cord-280878-1kt51viz	387	4	81-residue	81-residue	CD
cord-280878-1kt51viz	387	5	small	small	JJ
cord-280878-1kt51viz	387	6	-	-	HYPH
cord-280878-1kt51viz	387	7	membrane	membrane	NN
cord-280878-1kt51viz	387	8	protein	protein	NN
cord-280878-1kt51viz	387	9	encoded	encode	VBN
cord-280878-1kt51viz	387	10	by	by	IN
cord-280878-1kt51viz	387	11	the	the	DT
cord-280878-1kt51viz	387	12	singlestranded	singlestrande	VBN
cord-280878-1kt51viz	387	13	positive	positive	JJ
cord-280878-1kt51viz	387	14	-	-	HYPH
cord-280878-1kt51viz	387	15	sense	sense	NN
cord-280878-1kt51viz	387	16	RNA	RNA	NNP
cord-280878-1kt51viz	387	17	human	human	JJ
cord-280878-1kt51viz	387	18	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	387	19	virus	virus	NN
cord-280878-1kt51viz	387	20	1	1	CD
cord-280878-1kt51viz	387	21	(	(	-LRB-
cord-280878-1kt51viz	387	22	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	387	23	)	)	-RRB-
cord-280878-1kt51viz	387	24	,	,	,
cord-280878-1kt51viz	387	25	and	and	CC
cord-280878-1kt51viz	387	26	some	some	DT
cord-280878-1kt51viz	387	27	simian	simian	JJ
cord-280878-1kt51viz	387	28	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	387	29	virus	virus	NN
cord-280878-1kt51viz	387	30	(	(	-LRB-
cord-280878-1kt51viz	387	31	SIV	SIV	NNP
cord-280878-1kt51viz	387	32	)	)	-RRB-
cord-280878-1kt51viz	387	33	isolates	isolate	NNS
cord-280878-1kt51viz	387	34	.	.	.
cord-280878-1kt51viz	388	1	Vpu	Vpu	NNP
cord-280878-1kt51viz	388	2	is	be	VBZ
cord-280878-1kt51viz	388	3	one	one	CD
cord-280878-1kt51viz	388	4	of	of	IN
cord-280878-1kt51viz	388	5	four	four	CD
cord-280878-1kt51viz	388	6	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	388	7	accessory	accessory	NN
cord-280878-1kt51viz	388	8	proteins	protein	NNS
cord-280878-1kt51viz	388	9	involved	involve	VBN
cord-280878-1kt51viz	388	10	in	in	IN
cord-280878-1kt51viz	388	11	the	the	DT
cord-280878-1kt51viz	388	12	release	release	NN
cord-280878-1kt51viz	388	13	of	of	IN
cord-280878-1kt51viz	388	14	new	new	JJ
cord-280878-1kt51viz	388	15	virions	virion	NNS
cord-280878-1kt51viz	388	16	from	from	IN
cord-280878-1kt51viz	388	17	host	host	NN
cord-280878-1kt51viz	388	18	cell	cell	NN
cord-280878-1kt51viz	388	19	membranes	membrane	NNS
cord-280878-1kt51viz	388	20	(	(	-LRB-
cord-280878-1kt51viz	388	21	Cohen	Cohen	NNP
cord-280878-1kt51viz	388	22	,	,	,
cord-280878-1kt51viz	388	23	Terwilliger	Terwilliger	NNP
cord-280878-1kt51viz	388	24	,	,	,
cord-280878-1kt51viz	388	25	Sodroski	Sodroski	NNP
cord-280878-1kt51viz	388	26	,	,	,
cord-280878-1kt51viz	388	27	&	&	CC
cord-280878-1kt51viz	388	28	Haseltine	Haseltine	NNP
cord-280878-1kt51viz	388	29	,	,	,
cord-280878-1kt51viz	388	30	1988	1988	CD
cord-280878-1kt51viz	388	31	;	;	:
cord-280878-1kt51viz	388	32	Strebel	Strebel	NNP
cord-280878-1kt51viz	388	33	,	,	,
cord-280878-1kt51viz	388	34	Klimkait	Klimkait	NNP
cord-280878-1kt51viz	388	35	,	,	,
cord-280878-1kt51viz	388	36	&	&	CC
cord-280878-1kt51viz	388	37	Martin	Martin	NNP
cord-280878-1kt51viz	388	38	,	,	,
cord-280878-1kt51viz	388	39	1988	1988	CD
cord-280878-1kt51viz	388	40	;	;	:
cord-280878-1kt51viz	388	41	Terwilliger	Terwilliger	NNP
cord-280878-1kt51viz	388	42	,	,	,
cord-280878-1kt51viz	388	43	Cohen	Cohen	NNP
cord-280878-1kt51viz	388	44	,	,	,
cord-280878-1kt51viz	388	45	Lu	Lu	NNP
cord-280878-1kt51viz	388	46	,	,	,
cord-280878-1kt51viz	388	47	Sodroski	Sodroski	NNP
cord-280878-1kt51viz	388	48	,	,	,
cord-280878-1kt51viz	388	49	&	&	CC
cord-280878-1kt51viz	388	50	Haseltine	Haseltine	NNP
cord-280878-1kt51viz	388	51	,	,	,
cord-280878-1kt51viz	388	52	1989	1989	CD
cord-280878-1kt51viz	388	53	)	)	-RRB-
cord-280878-1kt51viz	388	54	.	.	.
cord-280878-1kt51viz	389	1	Without	without	IN
cord-280878-1kt51viz	389	2	Vpu	Vpu	NNP
cord-280878-1kt51viz	389	3	,	,	,
cord-280878-1kt51viz	389	4	HIV	HIV	NNP
cord-280878-1kt51viz	389	5	particles	particle	NNS
cord-280878-1kt51viz	389	6	fail	fail	VBP
cord-280878-1kt51viz	389	7	to	to	TO
cord-280878-1kt51viz	389	8	detach	detach	VB
cord-280878-1kt51viz	389	9	from	from	IN
cord-280878-1kt51viz	389	10	the	the	DT
cord-280878-1kt51viz	389	11	plasma	plasma	NN
cord-280878-1kt51viz	389	12	membrane	membrane	NN
cord-280878-1kt51viz	389	13	and	and	CC
cord-280878-1kt51viz	389	14	accumulate	accumulate	VBP
cord-280878-1kt51viz	389	15	in	in	IN
cord-280878-1kt51viz	389	16	large	large	JJ
cord-280878-1kt51viz	389	17	numbers	number	NNS
cord-280878-1kt51viz	389	18	in	in	IN
cord-280878-1kt51viz	389	19	the	the	DT
cord-280878-1kt51viz	389	20	cell	cell	NN
cord-280878-1kt51viz	389	21	surface	surface	NN
cord-280878-1kt51viz	389	22	(	(	-LRB-
cord-280878-1kt51viz	389	23	Klimkait	Klimkait	NNP
cord-280878-1kt51viz	389	24	,	,	,
cord-280878-1kt51viz	389	25	Strebel	Strebel	NNP
cord-280878-1kt51viz	389	26	,	,	,
cord-280878-1kt51viz	389	27	Hoggan	Hoggan	NNP
cord-280878-1kt51viz	389	28	,	,	,
cord-280878-1kt51viz	389	29	Martin	Martin	NNP
cord-280878-1kt51viz	389	30	,	,	,
cord-280878-1kt51viz	389	31	&	&	CC
cord-280878-1kt51viz	389	32	Orenstein	Orenstein	NNP
cord-280878-1kt51viz	389	33	,	,	,
cord-280878-1kt51viz	389	34	1990	1990	CD
cord-280878-1kt51viz	389	35	)	)	-RRB-
cord-280878-1kt51viz	389	36	.	.	.
cord-280878-1kt51viz	390	1	The	the	DT
cord-280878-1kt51viz	390	2	initial	initial	JJ
cord-280878-1kt51viz	390	3	structural	structural	JJ
cord-280878-1kt51viz	390	4	studies	study	NNS
cord-280878-1kt51viz	390	5	of	of	IN
cord-280878-1kt51viz	390	6	Vpu	Vpu	NNP
cord-280878-1kt51viz	390	7	were	be	VBD
cord-280878-1kt51viz	390	8	performed	perform	VBN
cord-280878-1kt51viz	390	9	more	more	JJR
cord-280878-1kt51viz	390	10	than	than	IN
cord-280878-1kt51viz	390	11	20	20	CD
cord-280878-1kt51viz	390	12	years	year	NNS
cord-280878-1kt51viz	390	13	ago	ago	RB
cord-280878-1kt51viz	390	14	by	by	IN
cord-280878-1kt51viz	390	15	solution	solution	NN
cord-280878-1kt51viz	390	16	NMR	NMR	NNP
cord-280878-1kt51viz	390	17	in	in	IN
cord-280878-1kt51viz	390	18	TFE	TFE	NNP
cord-280878-1kt51viz	390	19	/	/	SYM
cord-280878-1kt51viz	390	20	water	water	NN
cord-280878-1kt51viz	390	21	using	use	VBG
cord-280878-1kt51viz	390	22	synthetic	synthetic	JJ
cord-280878-1kt51viz	390	23	peptides	peptide	NNS
cord-280878-1kt51viz	390	24	of	of	IN
cord-280878-1kt51viz	390	25	various	various	JJ
cord-280878-1kt51viz	390	26	overlapping	overlapping	JJ
cord-280878-1kt51viz	390	27	lengths	length	NNS
cord-280878-1kt51viz	390	28	,	,	,
cord-280878-1kt51viz	390	29	which	which	WDT
cord-280878-1kt51viz	390	30	led	lead	VBD
cord-280878-1kt51viz	390	31	to	to	IN
cord-280878-1kt51viz	390	32	a	a	DT
cord-280878-1kt51viz	390	33	model	model	NN
cord-280878-1kt51viz	390	34	of	of	IN
cord-280878-1kt51viz	390	35	an	an	DT
cord-280878-1kt51viz	390	36	N	n	CD
cord-280878-1kt51viz	390	37	-	-	HYPH
cord-280878-1kt51viz	390	38	terminal	terminal	JJ
cord-280878-1kt51viz	390	39	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	390	40	transmembrane	transmembrane	NN
cord-280878-1kt51viz	390	41	helix	helix	NN
cord-280878-1kt51viz	390	42	(	(	-LRB-
cord-280878-1kt51viz	390	43	the	the	DT
cord-280878-1kt51viz	390	44	TM	TM	NNP
cord-280878-1kt51viz	390	45	domain	domain	NN
cord-280878-1kt51viz	390	46	)	)	-RRB-
cord-280878-1kt51viz	390	47	and	and	CC
cord-280878-1kt51viz	390	48	a	a	DT
cord-280878-1kt51viz	390	49	C	c	NN
cord-280878-1kt51viz	390	50	-	-	HYPH
cord-280878-1kt51viz	390	51	terminal	terminal	JJ
cord-280878-1kt51viz	390	52	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	390	53	domain	domain	NN
cord-280878-1kt51viz	390	54	with	with	IN
cord-280878-1kt51viz	390	55	a	a	DT
cord-280878-1kt51viz	390	56	helix	helix	NN
cord-280878-1kt51viz	390	57	-	-	HYPH
cord-280878-1kt51viz	390	58	loop	loop	NN
cord-280878-1kt51viz	390	59	-	-	HYPH
cord-280878-1kt51viz	390	60	helix	helix	NN
cord-280878-1kt51viz	390	61	arrangement	arrangement	NN
cord-280878-1kt51viz	390	62	[	[	-LRB-
cord-280878-1kt51viz	390	63	reviewed	review	VBN
cord-280878-1kt51viz	390	64	recently	recently	RB
cord-280878-1kt51viz	390	65	in	in	IN
cord-280878-1kt51viz	390	66	Opella	Opella	NNP
cord-280878-1kt51viz	390	67	,	,	,
cord-280878-1kt51viz	390	68	2015	2015	CD
cord-280878-1kt51viz	390	69	]	]	-RRB-
cord-280878-1kt51viz	390	70	.	.	.
cord-280878-1kt51viz	391	1	Structural	structural	JJ
cord-280878-1kt51viz	391	2	similarity	similarity	NN
cord-280878-1kt51viz	391	3	of	of	IN
cord-280878-1kt51viz	391	4	Vpu	Vpu	NNP
cord-280878-1kt51viz	391	5	with	with	IN
cord-280878-1kt51viz	391	6	AM2	AM2	NNP
cord-280878-1kt51viz	391	7	suggested	suggest	VBD
cord-280878-1kt51viz	391	8	that	that	IN
cord-280878-1kt51viz	391	9	Vpu	Vpu	NNP
cord-280878-1kt51viz	391	10	could	could	MD
cord-280878-1kt51viz	391	11	form	form	VB
cord-280878-1kt51viz	391	12	pores	pore	NNS
cord-280878-1kt51viz	391	13	(	(	-LRB-
cord-280878-1kt51viz	391	14	Maldarelli	Maldarelli	NNP
cord-280878-1kt51viz	391	15	,	,	,
cord-280878-1kt51viz	391	16	Chen	Chen	NNP
cord-280878-1kt51viz	391	17	,	,	,
cord-280878-1kt51viz	391	18	Willey	Willey	NNP
cord-280878-1kt51viz	391	19	,	,	,
cord-280878-1kt51viz	391	20	&	&	CC
cord-280878-1kt51viz	391	21	Strebel	Strebel	NNP
cord-280878-1kt51viz	391	22	,	,	,
cord-280878-1kt51viz	391	23	1993	1993	CD
cord-280878-1kt51viz	391	24	)	)	-RRB-
cord-280878-1kt51viz	391	25	and	and	CC
cord-280878-1kt51viz	391	26	was	be	VBD
cord-280878-1kt51viz	391	27	later	later	RB
cord-280878-1kt51viz	391	28	shown	show	VBN
cord-280878-1kt51viz	391	29	to	to	TO
cord-280878-1kt51viz	391	30	have	have	VB
cord-280878-1kt51viz	391	31	cation	cation	NN
cord-280878-1kt51viz	391	32	-	-	HYPH
cord-280878-1kt51viz	391	33	selective	selective	JJ
cord-280878-1kt51viz	391	34	channel	channel	NN
cord-280878-1kt51viz	391	35	activity	activity	NN
cord-280878-1kt51viz	391	36	(	(	-LRB-
cord-280878-1kt51viz	391	37	Ewart	Ewart	NNP
cord-280878-1kt51viz	391	38	,	,	,
cord-280878-1kt51viz	391	39	Sutherland	Sutherland	NNP
cord-280878-1kt51viz	391	40	,	,	,
cord-280878-1kt51viz	391	41	Gage	Gage	NNP
cord-280878-1kt51viz	391	42	,	,	,
cord-280878-1kt51viz	391	43	&	&	CC
cord-280878-1kt51viz	391	44	Cox	Cox	NNP
cord-280878-1kt51viz	391	45	,	,	,
cord-280878-1kt51viz	391	46	1996	1996	CD
cord-280878-1kt51viz	391	47	;	;	:
cord-280878-1kt51viz	391	48	Schubert	Schubert	NNP
cord-280878-1kt51viz	391	49	et	et	NNP
cord-280878-1kt51viz	391	50	al	al	NNP
cord-280878-1kt51viz	391	51	.	.	NNP
cord-280878-1kt51viz	391	52	,	,	,
cord-280878-1kt51viz	391	53	1996	1996	CD
cord-280878-1kt51viz	391	54	)	)	-RRB-
cord-280878-1kt51viz	391	55	,	,	,
cord-280878-1kt51viz	391	56	but	but	CC
cord-280878-1kt51viz	391	57	a	a	DT
cord-280878-1kt51viz	391	58	unique	unique	JJ
cord-280878-1kt51viz	391	59	structural	structural	JJ
cord-280878-1kt51viz	391	60	model	model	NN
cord-280878-1kt51viz	391	61	for	for	IN
cord-280878-1kt51viz	391	62	the	the	DT
cord-280878-1kt51viz	391	63	Vpu	Vpu	NNP
cord-280878-1kt51viz	391	64	oligomer	oligomer	NN
cord-280878-1kt51viz	391	65	can	can	MD
cord-280878-1kt51viz	391	66	not	not	RB
cord-280878-1kt51viz	391	67	be	be	VB
cord-280878-1kt51viz	391	68	defined	define	VBN
cord-280878-1kt51viz	391	69	[	[	-LRB-
cord-280878-1kt51viz	391	70	reviewed	review	VBN
cord-280878-1kt51viz	391	71	in	in	IN
cord-280878-1kt51viz	391	72	Radoicic	Radoicic	NNP
cord-280878-1kt51viz	391	73	,	,	,
cord-280878-1kt51viz	391	74	Lu	Lu	NNP
cord-280878-1kt51viz	391	75	,	,	,
cord-280878-1kt51viz	391	76	&	&	CC
cord-280878-1kt51viz	391	77	Opella	Opella	NNP
cord-280878-1kt51viz	391	78	,	,	,
cord-280878-1kt51viz	391	79	2014	2014	CD
cord-280878-1kt51viz	391	80	]	]	-RRB-
cord-280878-1kt51viz	391	81	.	.	.
cord-280878-1kt51viz	392	1	An	an	DT
cord-280878-1kt51viz	392	2	analysis	analysis	NN
cord-280878-1kt51viz	392	3	of	of	IN
cord-280878-1kt51viz	392	4	the	the	DT
cord-280878-1kt51viz	392	5	Vpu	Vpu	NNP
cord-280878-1kt51viz	392	6	TM	TM	NNP
cord-280878-1kt51viz	392	7	(	(	-LRB-
cord-280878-1kt51viz	392	8	residues	residue	NNS
cord-280878-1kt51viz	392	9	1	1	CD
cord-280878-1kt51viz	392	10	-	-	SYM
cord-280878-1kt51viz	392	11	40	40	CD
cord-280878-1kt51viz	392	12	)	)	-RRB-
cord-280878-1kt51viz	392	13	by	by	IN
cord-280878-1kt51viz	392	14	solid	solid	JJ
cord-280878-1kt51viz	392	15	-	-	HYPH
cord-280878-1kt51viz	392	16	state	state	NN
cord-280878-1kt51viz	392	17	NMR	nmr	NN
cord-280878-1kt51viz	392	18	in	in	IN
cord-280878-1kt51viz	392	19	membranes	membrane	NNS
cord-280878-1kt51viz	392	20	,	,	,
cord-280878-1kt51viz	392	21	combined	combine	VBN
cord-280878-1kt51viz	392	22	with	with	IN
cord-280878-1kt51viz	392	23	analytical	analytical	JJ
cord-280878-1kt51viz	392	24	centrifugation	centrifugation	NN
cord-280878-1kt51viz	392	25	measurements	measurement	NNS
cord-280878-1kt51viz	392	26	in	in	IN
cord-280878-1kt51viz	392	27	detergent	detergent	NN
cord-280878-1kt51viz	392	28	,	,	,
cord-280878-1kt51viz	392	29	produced	produce	VBD
cord-280878-1kt51viz	392	30	data	datum	NNS
cord-280878-1kt51viz	392	31	compatible	compatible	JJ
cord-280878-1kt51viz	392	32	with	with	IN
cord-280878-1kt51viz	392	33	a	a	DT
cord-280878-1kt51viz	392	34	variety	variety	NN
cord-280878-1kt51viz	392	35	of	of	IN
cord-280878-1kt51viz	392	36	oligomers	oligomer	NNS
cord-280878-1kt51viz	392	37	coexisting	coexist	VBG
cord-280878-1kt51viz	392	38	in	in	IN
cord-280878-1kt51viz	392	39	micelles	micelle	NNS
cord-280878-1kt51viz	392	40	and	and	CC
cord-280878-1kt51viz	392	41	phospholipid	phospholipid	NN
cord-280878-1kt51viz	392	42	bilayers	bilayer	NNS
cord-280878-1kt51viz	392	43	(	(	-LRB-
cord-280878-1kt51viz	392	44	Lu	Lu	NNP
cord-280878-1kt51viz	392	45	,	,	,
cord-280878-1kt51viz	392	46	Sharpe	Sharpe	NNP
cord-280878-1kt51viz	392	47	,	,	,
cord-280878-1kt51viz	392	48	Ghirlando	Ghirlando	NNP
cord-280878-1kt51viz	392	49	,	,	,
cord-280878-1kt51viz	392	50	Yau	Yau	NNP
cord-280878-1kt51viz	392	51	,	,	,
cord-280878-1kt51viz	392	52	&	&	CC
cord-280878-1kt51viz	392	53	Tycko	Tycko	NNP
cord-280878-1kt51viz	392	54	,	,	,
cord-280878-1kt51viz	392	55	2010	2010	CD
cord-280878-1kt51viz	392	56	)	)	-RRB-
cord-280878-1kt51viz	392	57	.	.	.
cord-280878-1kt51viz	393	1	This	this	DT
cord-280878-1kt51viz	393	2	led	lead	VBD
cord-280878-1kt51viz	393	3	to	to	IN
cord-280878-1kt51viz	393	4	the	the	DT
cord-280878-1kt51viz	393	5	proposal	proposal	NN
cord-280878-1kt51viz	393	6	that	that	IN
cord-280878-1kt51viz	393	7	regulation	regulation	NN
cord-280878-1kt51viz	393	8	of	of	IN
cord-280878-1kt51viz	393	9	virus	virus	NN
cord-280878-1kt51viz	393	10	release	release	NN
cord-280878-1kt51viz	393	11	by	by	IN
cord-280878-1kt51viz	393	12	Vpu	Vpu	NNP
cord-280878-1kt51viz	393	13	might	may	MD
cord-280878-1kt51viz	393	14	involve	involve	VB
cord-280878-1kt51viz	393	15	an	an	DT
cord-280878-1kt51viz	393	16	alteration	alteration	NN
cord-280878-1kt51viz	393	17	of	of	IN
cord-280878-1kt51viz	393	18	the	the	DT
cord-280878-1kt51viz	393	19	plasma	plasma	NN
cord-280878-1kt51viz	393	20	membrane	membrane	NN
cord-280878-1kt51viz	393	21	potential	potential	NN
cord-280878-1kt51viz	393	22	,	,	,
cord-280878-1kt51viz	393	23	and	and	CC
cord-280878-1kt51viz	393	24	this	this	DT
cord-280878-1kt51viz	393	25	was	be	VBD
cord-280878-1kt51viz	393	26	supported	support	VBN
cord-280878-1kt51viz	393	27	by	by	IN
cord-280878-1kt51viz	393	28	(	(	-LRB-
cord-280878-1kt51viz	393	29	i	i	NN
cord-280878-1kt51viz	393	30	)	)	-RRB-
cord-280878-1kt51viz	394	1	the	the	DT
cord-280878-1kt51viz	394	2	reduced	reduce	VBN
cord-280878-1kt51viz	394	3	rate	rate	NN
cord-280878-1kt51viz	394	4	of	of	IN
cord-280878-1kt51viz	394	5	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	394	6	virus	virus	NN
cord-280878-1kt51viz	394	7	release	release	NN
cord-280878-1kt51viz	394	8	after	after	IN
cord-280878-1kt51viz	394	9	membrane	membrane	NN
cord-280878-1kt51viz	394	10	depolarization	depolarization	NN
cord-280878-1kt51viz	394	11	(	(	-LRB-
cord-280878-1kt51viz	394	12	Hsu	Hsu	NNP
cord-280878-1kt51viz	394	13	,	,	,
cord-280878-1kt51viz	394	14	Han	Han	NNP
cord-280878-1kt51viz	394	15	,	,	,
cord-280878-1kt51viz	394	16	Shinlapawittayatorn	Shinlapawittayatorn	NNP
cord-280878-1kt51viz	394	17	,	,	,
cord-280878-1kt51viz	394	18	Deschenes	Deschenes	NNP
cord-280878-1kt51viz	394	19	,	,	,
cord-280878-1kt51viz	394	20	&	&	CC
cord-280878-1kt51viz	394	21	Marbán	Marbán	NNP
cord-280878-1kt51viz	394	22	,	,	,
cord-280878-1kt51viz	394	23	2010	2010	CD
cord-280878-1kt51viz	394	24	)	)	-RRB-
cord-280878-1kt51viz	394	25	,	,	,
cord-280878-1kt51viz	394	26	(	(	-LRB-
cord-280878-1kt51viz	394	27	ii	ii	NN
cord-280878-1kt51viz	394	28	)	)	-RRB-
cord-280878-1kt51viz	394	29	the	the	DT
cord-280878-1kt51viz	394	30	observed	observed	JJ
cord-280878-1kt51viz	394	31	reduction	reduction	NN
cord-280878-1kt51viz	394	32	in	in	IN
cord-280878-1kt51viz	394	33	viral	viral	JJ
cord-280878-1kt51viz	394	34	load	load	NN
cord-280878-1kt51viz	394	35	and	and	CC
cord-280878-1kt51viz	394	36	viral	viral	JJ
cord-280878-1kt51viz	394	37	pathogenicity	pathogenicity	NN
cord-280878-1kt51viz	394	38	when	when	WRB
cord-280878-1kt51viz	394	39	Vpu	Vpu	NNP
cord-280878-1kt51viz	394	40	TM	TM	NNP
cord-280878-1kt51viz	394	41	domain	domain	NN
cord-280878-1kt51viz	394	42	is	be	VBZ
cord-280878-1kt51viz	394	43	scrambled	scramble	VBN
cord-280878-1kt51viz	394	44	in	in	IN
cord-280878-1kt51viz	394	45	the	the	DT
cord-280878-1kt51viz	394	46	context	context	NN
cord-280878-1kt51viz	394	47	of	of	IN
cord-280878-1kt51viz	394	48	a	a	DT
cord-280878-1kt51viz	394	49	simian	simian	JJ
cord-280878-1kt51viz	394	50	-	-	HYPH
cord-280878-1kt51viz	394	51	human	human	JJ
cord-280878-1kt51viz	394	52	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	394	53	virus	virus	NN
cord-280878-1kt51viz	394	54	(	(	-LRB-
cord-280878-1kt51viz	394	55	SHIV	SHIV	NNP
cord-280878-1kt51viz	394	56	)	)	-RRB-
cord-280878-1kt51viz	394	57	(	(	-LRB-
cord-280878-1kt51viz	394	58	Hout	Hout	NNP
cord-280878-1kt51viz	394	59	et	et	NNP
cord-280878-1kt51viz	394	60	al	al	NNP
cord-280878-1kt51viz	394	61	.	.	NNP
cord-280878-1kt51viz	394	62	,	,	,
cord-280878-1kt51viz	394	63	2005	2005	CD
cord-280878-1kt51viz	394	64	)	)	-RRB-
cord-280878-1kt51viz	394	65	,	,	,
cord-280878-1kt51viz	394	66	and	and	CC
cord-280878-1kt51viz	394	67	(	(	-LRB-
cord-280878-1kt51viz	394	68	iii	iii	NN
cord-280878-1kt51viz	394	69	)	)	-RRB-
cord-280878-1kt51viz	394	70	the	the	DT
cord-280878-1kt51viz	394	71	substitution	substitution	NN
cord-280878-1kt51viz	394	72	of	of	IN
cord-280878-1kt51viz	394	73	Ala-18	Ala-18	NNP
cord-280878-1kt51viz	394	74	by	by	IN
cord-280878-1kt51viz	394	75	a	a	DT
cord-280878-1kt51viz	394	76	histidine	histidine	NN
cord-280878-1kt51viz	394	77	(	(	-LRB-
cord-280878-1kt51viz	394	78	A18H	a18h	NN
cord-280878-1kt51viz	394	79	)	)	-RRB-
cord-280878-1kt51viz	394	80	rendered	render	VBN
cord-280878-1kt51viz	394	81	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	394	82	infections	infection	NNS
cord-280878-1kt51viz	394	83	susceptible	susceptible	JJ
cord-280878-1kt51viz	394	84	to	to	IN
cord-280878-1kt51viz	394	85	Rim	rim	NN
cord-280878-1kt51viz	394	86	(	(	-LRB-
cord-280878-1kt51viz	394	87	Hout	Hout	NNP
cord-280878-1kt51viz	394	88	et	et	NNP
cord-280878-1kt51viz	394	89	al	al	NNP
cord-280878-1kt51viz	394	90	.	.	NNP
cord-280878-1kt51viz	394	91	,	,	,
cord-280878-1kt51viz	394	92	2006	2006	CD
cord-280878-1kt51viz	394	93	)	)	-RRB-
cord-280878-1kt51viz	394	94	.	.	.
cord-280878-1kt51viz	395	1	However	however	RB
cord-280878-1kt51viz	395	2	,	,	,
cord-280878-1kt51viz	395	3	recent	recent	JJ
cord-280878-1kt51viz	395	4	studies	study	NNS
cord-280878-1kt51viz	395	5	challenge	challenge	VBP
cord-280878-1kt51viz	395	6	this	this	DT
cord-280878-1kt51viz	395	7	model	model	NN
cord-280878-1kt51viz	395	8	and	and	CC
cord-280878-1kt51viz	395	9	argue	argue	VBP
cord-280878-1kt51viz	395	10	against	against	IN
cord-280878-1kt51viz	395	11	a	a	DT
cord-280878-1kt51viz	395	12	critical	critical	JJ
cord-280878-1kt51viz	395	13	involvement	involvement	NN
cord-280878-1kt51viz	395	14	of	of	IN
cord-280878-1kt51viz	395	15	Vpu	Vpu	NNP
cord-280878-1kt51viz	395	16	ion	ion	NN
cord-280878-1kt51viz	395	17	channel	channel	NN
cord-280878-1kt51viz	395	18	activity	activity	NN
cord-280878-1kt51viz	395	19	in	in	IN
cord-280878-1kt51viz	395	20	Vpu	Vpu	NNP
cord-280878-1kt51viz	395	21	-	-	HYPH
cord-280878-1kt51viz	395	22	enhanced	enhance	VBN
cord-280878-1kt51viz	395	23	virus	virus	NN
cord-280878-1kt51viz	395	24	release	release	NN
cord-280878-1kt51viz	395	25	.	.	.
cord-280878-1kt51viz	396	1	Indeed	indeed	RB
cord-280878-1kt51viz	396	2	,	,	,
cord-280878-1kt51viz	396	3	mutations	mutation	NNS
cord-280878-1kt51viz	396	4	in	in	IN
cord-280878-1kt51viz	396	5	the	the	DT
cord-280878-1kt51viz	396	6	Vpu	Vpu	NNP
cord-280878-1kt51viz	396	7	TM	TM	NNP
cord-280878-1kt51viz	396	8	domain	domain	NN
cord-280878-1kt51viz	396	9	that	that	WDT
cord-280878-1kt51viz	396	10	affect	affect	VBP
cord-280878-1kt51viz	396	11	channel	channel	NN
cord-280878-1kt51viz	396	12	activity	activity	NN
cord-280878-1kt51viz	396	13	do	do	VBP
cord-280878-1kt51viz	396	14	not	not	RB
cord-280878-1kt51viz	396	15	impair	impair	VB
cord-280878-1kt51viz	396	16	the	the	DT
cord-280878-1kt51viz	396	17	ability	ability	NN
cord-280878-1kt51viz	396	18	to	to	TO
cord-280878-1kt51viz	396	19	enhance	enhance	VB
cord-280878-1kt51viz	396	20	virus	virus	NN
cord-280878-1kt51viz	396	21	release	release	NN
cord-280878-1kt51viz	396	22	,	,	,
cord-280878-1kt51viz	396	23	whereas	whereas	IN
cord-280878-1kt51viz	396	24	mutations	mutation	NNS
cord-280878-1kt51viz	396	25	that	that	WDT
cord-280878-1kt51viz	396	26	affect	affect	VBP
cord-280878-1kt51viz	396	27	virus	virus	NN
cord-280878-1kt51viz	396	28	release	release	NN
cord-280878-1kt51viz	396	29	retain	retain	VB
cord-280878-1kt51viz	396	30	ion	ion	NN
cord-280878-1kt51viz	396	31	channel	channel	NN
cord-280878-1kt51viz	396	32	activity	activity	NN
cord-280878-1kt51viz	397	1	(	(	-LRB-
cord-280878-1kt51viz	397	2	Bolduan	Bolduan	NNP
cord-280878-1kt51viz	397	3	et	et	NNP
cord-280878-1kt51viz	397	4	al	al	NNP
cord-280878-1kt51viz	397	5	.	.	NNP
cord-280878-1kt51viz	397	6	,	,	,
cord-280878-1kt51viz	397	7	2011	2011	CD
cord-280878-1kt51viz	397	8	)	)	-RRB-
cord-280878-1kt51viz	397	9	.	.	.
cord-280878-1kt51viz	398	1	Thus	thus	RB
cord-280878-1kt51viz	398	2	,	,	,
cord-280878-1kt51viz	398	3	the	the	DT
cord-280878-1kt51viz	398	4	functional	functional	JJ
cord-280878-1kt51viz	398	5	significance	significance	NN
cord-280878-1kt51viz	398	6	of	of	IN
cord-280878-1kt51viz	398	7	Vpu	Vpu	NNP
cord-280878-1kt51viz	398	8	ion	ion	NN
cord-280878-1kt51viz	398	9	channel	channel	NN
cord-280878-1kt51viz	398	10	activity	activity	NN
cord-280878-1kt51viz	398	11	for	for	IN
cord-280878-1kt51viz	398	12	HIV	HIV	NNP
cord-280878-1kt51viz	398	13	replication	replication	NN
cord-280878-1kt51viz	398	14	,	,	,
cord-280878-1kt51viz	398	15	and	and	CC
cord-280878-1kt51viz	398	16	the	the	DT
cord-280878-1kt51viz	398	17	role	role	NN
cord-280878-1kt51viz	398	18	as	as	IN
cord-280878-1kt51viz	398	19	a	a	DT
cord-280878-1kt51viz	398	20	target	target	NN
cord-280878-1kt51viz	398	21	for	for	IN
cord-280878-1kt51viz	398	22	channel	channel	NN
cord-280878-1kt51viz	398	23	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	398	24	,	,	,
cord-280878-1kt51viz	398	25	remains	remain	VBZ
cord-280878-1kt51viz	398	26	unclear	unclear	JJ
cord-280878-1kt51viz	398	27	.	.	.
cord-280878-1kt51viz	399	1	There	there	EX
cord-280878-1kt51viz	399	2	are	be	VBP
cord-280878-1kt51viz	399	3	several	several	JJ
cord-280878-1kt51viz	399	4	other	other	JJ
cord-280878-1kt51viz	399	5	viroporins	viroporin	NNS
cord-280878-1kt51viz	399	6	of	of	IN
cord-280878-1kt51viz	399	7	which	which	WDT
cord-280878-1kt51viz	399	8	only	only	RB
cord-280878-1kt51viz	399	9	very	very	RB
cord-280878-1kt51viz	399	10	limited	limited	JJ
cord-280878-1kt51viz	399	11	structural	structural	JJ
cord-280878-1kt51viz	399	12	data	data	NN
cord-280878-1kt51viz	399	13	is	be	VBZ
cord-280878-1kt51viz	399	14	available	available	JJ
cord-280878-1kt51viz	399	15	,	,	,
cord-280878-1kt51viz	399	16	and	and	CC
cord-280878-1kt51viz	399	17	no	no	DT
cord-280878-1kt51viz	399	18	channel	channel	NN
cord-280878-1kt51viz	399	19	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	399	20	have	have	VBP
cord-280878-1kt51viz	399	21	been	be	VBN
cord-280878-1kt51viz	399	22	reported	report	VBN
cord-280878-1kt51viz	399	23	.	.	.
cord-280878-1kt51viz	400	1	The	the	DT
cord-280878-1kt51viz	400	2	following	following	JJ
cord-280878-1kt51viz	400	3	section	section	NN
cord-280878-1kt51viz	400	4	will	will	MD
cord-280878-1kt51viz	400	5	briefly	briefly	RB
cord-280878-1kt51viz	400	6	describe	describe	VB
cord-280878-1kt51viz	400	7	three	three	CD
cord-280878-1kt51viz	400	8	of	of	IN
cord-280878-1kt51viz	400	9	such	such	JJ
cord-280878-1kt51viz	400	10	viroporins	viroporin	NNS
cord-280878-1kt51viz	400	11	:	:	:
cord-280878-1kt51viz	400	12	the	the	DT
cord-280878-1kt51viz	400	13	alphavirus	alphavirus	NNP
cord-280878-1kt51viz	400	14	6	6	CD
cord-280878-1kt51viz	400	15	K	K	NNP
cord-280878-1kt51viz	400	16	protein	protein	NN
cord-280878-1kt51viz	400	17	,	,	,
cord-280878-1kt51viz	400	18	polyomavirus	polyomavirus	NNP
cord-280878-1kt51viz	400	19	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	400	20	,	,	,
cord-280878-1kt51viz	400	21	and	and	CC
cord-280878-1kt51viz	400	22	the	the	DT
cord-280878-1kt51viz	400	23	2B	2B	NNP
cord-280878-1kt51viz	400	24	protein	protein	NNP
cord-280878-1kt51viz	400	25	found	find	VBD
cord-280878-1kt51viz	400	26	in	in	IN
cord-280878-1kt51viz	400	27	picornaviruses	picornavirus	NNS
cord-280878-1kt51viz	400	28	.	.	.
cord-280878-1kt51viz	401	1	The	the	DT
cord-280878-1kt51viz	401	2	6	6	CD
cord-280878-1kt51viz	401	3	K	K	NNP
cord-280878-1kt51viz	401	4	protein	protein	NN
cord-280878-1kt51viz	401	5	is	be	VBZ
cord-280878-1kt51viz	401	6	58	58	CD
cord-280878-1kt51viz	401	7	-	-	SYM
cord-280878-1kt51viz	401	8	61	61	CD
cord-280878-1kt51viz	401	9	amino	amino	JJ
cord-280878-1kt51viz	401	10	acids	acid	NNS
cord-280878-1kt51viz	401	11	long	long	RB
cord-280878-1kt51viz	401	12	and	and	CC
cord-280878-1kt51viz	401	13	has	have	VBZ
cord-280878-1kt51viz	401	14	one	one	CD
cord-280878-1kt51viz	401	15	predicted	predict	VBN
cord-280878-1kt51viz	401	16	α	α	NN
cord-280878-1kt51viz	401	17	-	-	HYPH
cord-280878-1kt51viz	401	18	helical	helical	JJ
cord-280878-1kt51viz	401	19	TM	TM	NNP
cord-280878-1kt51viz	401	20	domain	domain	NN
cord-280878-1kt51viz	401	21	.	.	.
cord-280878-1kt51viz	402	1	This	this	DT
cord-280878-1kt51viz	402	2	viroporin	viroporin	NN
cord-280878-1kt51viz	402	3	is	be	VBZ
cord-280878-1kt51viz	402	4	found	find	VBN
cord-280878-1kt51viz	402	5	in	in	IN
cord-280878-1kt51viz	402	6	several	several	JJ
cord-280878-1kt51viz	402	7	members	member	NNS
cord-280878-1kt51viz	402	8	of	of	IN
cord-280878-1kt51viz	402	9	the	the	DT
cord-280878-1kt51viz	402	10	alphavirus	alphavirus	NNP
cord-280878-1kt51viz	402	11	genus	genus	NN
cord-280878-1kt51viz	402	12	in	in	IN
cord-280878-1kt51viz	402	13	the	the	DT
cord-280878-1kt51viz	402	14	positive	positive	JJ
cord-280878-1kt51viz	402	15	-	-	HYPH
cord-280878-1kt51viz	402	16	sense	sense	NN
cord-280878-1kt51viz	402	17	RNA	RNA	NNP
cord-280878-1kt51viz	402	18	family	family	NN
cord-280878-1kt51viz	402	19	Togaviridae	Togaviridae	NNP
cord-280878-1kt51viz	402	20	.	.	.
cord-280878-1kt51viz	403	1	This	this	DT
cord-280878-1kt51viz	403	2	includes	include	VBZ
cord-280878-1kt51viz	403	3	,	,	,
cord-280878-1kt51viz	403	4	for	for	IN
cord-280878-1kt51viz	403	5	example	example	NN
cord-280878-1kt51viz	403	6	,	,	,
cord-280878-1kt51viz	403	7	equine	equine	NN
cord-280878-1kt51viz	403	8	encephalitis	encephalitis	NN
cord-280878-1kt51viz	403	9	viruses	virus	NNS
cord-280878-1kt51viz	403	10	,	,	,
cord-280878-1kt51viz	403	11	Chikungunya	chikungunya	NN
cord-280878-1kt51viz	403	12	virus	virus	NN
cord-280878-1kt51viz	403	13	,	,	,
cord-280878-1kt51viz	403	14	Sindbis	Sindbis	NNP
cord-280878-1kt51viz	403	15	virus	virus	NN
cord-280878-1kt51viz	403	16	,	,	,
cord-280878-1kt51viz	403	17	Semliki	Semliki	NNP
cord-280878-1kt51viz	403	18	Forest	Forest	NNP
cord-280878-1kt51viz	403	19	viruses	virus	NNS
cord-280878-1kt51viz	403	20	(	(	-LRB-
cord-280878-1kt51viz	403	21	SFV	SFV	NNP
cord-280878-1kt51viz	403	22	)	)	-RRB-
cord-280878-1kt51viz	403	23	,	,	,
cord-280878-1kt51viz	403	24	Ross	Ross	NNP
cord-280878-1kt51viz	403	25	River	River	NNP
cord-280878-1kt51viz	403	26	virus	virus	NN
cord-280878-1kt51viz	403	27	(	(	-LRB-
cord-280878-1kt51viz	403	28	RRV	RRV	NNP
cord-280878-1kt51viz	403	29	)	)	-RRB-
cord-280878-1kt51viz	403	30	,	,	,
cord-280878-1kt51viz	403	31	and	and	CC
cord-280878-1kt51viz	403	32	Barmah	Barmah	NNP
cord-280878-1kt51viz	403	33	Forest	Forest	NNP
cord-280878-1kt51viz	403	34	virus	virus	NN
cord-280878-1kt51viz	403	35	(	(	-LRB-
cord-280878-1kt51viz	403	36	BFV	BFV	NNP
cord-280878-1kt51viz	403	37	)	)	-RRB-
cord-280878-1kt51viz	403	38	.	.	.
cord-280878-1kt51viz	404	1	In	in	IN
cord-280878-1kt51viz	404	2	these	these	DT
cord-280878-1kt51viz	404	3	viruses	virus	NNS
cord-280878-1kt51viz	404	4	,	,	,
cord-280878-1kt51viz	404	5	structural	structural	JJ
cord-280878-1kt51viz	404	6	proteins	protein	NNS
cord-280878-1kt51viz	404	7	are	be	VBP
cord-280878-1kt51viz	404	8	translated	translate	VBN
cord-280878-1kt51viz	404	9	in	in	IN
cord-280878-1kt51viz	404	10	the	the	DT
cord-280878-1kt51viz	404	11	ER	ER	NNP
cord-280878-1kt51viz	404	12	from	from	IN
cord-280878-1kt51viz	404	13	a	a	DT
cord-280878-1kt51viz	404	14	subgenomic	subgenomic	NNP
cord-280878-1kt51viz	404	15	mRNA	mrna	NN
cord-280878-1kt51viz	404	16	as	as	IN
cord-280878-1kt51viz	404	17	a	a	DT
cord-280878-1kt51viz	404	18	single	single	JJ
cord-280878-1kt51viz	404	19	polyprotein	polyprotein	NN
cord-280878-1kt51viz	404	20	later	later	RB
cord-280878-1kt51viz	404	21	cleaved	cleave	VBN
cord-280878-1kt51viz	404	22	by	by	IN
cord-280878-1kt51viz	404	23	proteases	protease	NNS
cord-280878-1kt51viz	404	24	,	,	,
cord-280878-1kt51viz	404	25	in	in	IN
cord-280878-1kt51viz	404	26	the	the	DT
cord-280878-1kt51viz	404	27	order	order	NN
cord-280878-1kt51viz	404	28	capsid	capsid	NN
cord-280878-1kt51viz	404	29	-	-	HYPH
cord-280878-1kt51viz	404	30	PE2	PE2	NNP
cord-280878-1kt51viz	404	31	-	-	HYPH
cord-280878-1kt51viz	404	32	6K	6k	CD
cord-280878-1kt51viz	404	33	-	-	HYPH
cord-280878-1kt51viz	404	34	E1	E1	NNP
cord-280878-1kt51viz	404	35	Strauss	Strauss	NNP
cord-280878-1kt51viz	404	36	&	&	CC
cord-280878-1kt51viz	404	37	Strauss	Strauss	NNP
cord-280878-1kt51viz	404	38	,	,	,
cord-280878-1kt51viz	404	39	1994	1994	CD
cord-280878-1kt51viz	404	40	)	)	-RRB-
cord-280878-1kt51viz	404	41	.	.	.
cord-280878-1kt51viz	405	1	The	the	DT
cord-280878-1kt51viz	405	2	6	6	CD
cord-280878-1kt51viz	405	3	K	K	NNP
cord-280878-1kt51viz	405	4	protein	protein	NN
cord-280878-1kt51viz	405	5	was	be	VBD
cord-280878-1kt51viz	405	6	first	first	RB
cord-280878-1kt51viz	405	7	described	describe	VBN
cord-280878-1kt51viz	405	8	as	as	RB
cord-280878-1kt51viz	405	9	early	early	RB
cord-280878-1kt51viz	405	10	as	as	IN
cord-280878-1kt51viz	405	11	1980	1980	CD
cord-280878-1kt51viz	405	12	(	(	-LRB-
cord-280878-1kt51viz	405	13	Welch	Welch	NNP
cord-280878-1kt51viz	405	14	&	&	CC
cord-280878-1kt51viz	405	15	Sefton	Sefton	NNP
cord-280878-1kt51viz	405	16	,	,	,
cord-280878-1kt51viz	405	17	1980	1980	CD
cord-280878-1kt51viz	405	18	)	)	-RRB-
cord-280878-1kt51viz	405	19	.	.	.
cord-280878-1kt51viz	406	1	Its	-PRON-	PRP$
cord-280878-1kt51viz	406	2	expression	expression	NN
cord-280878-1kt51viz	406	3	in	in	IN
cord-280878-1kt51viz	406	4	E.	E.	NNP
cord-280878-1kt51viz	406	5	coli	coli	NNS
cord-280878-1kt51viz	406	6	caused	cause	VBD
cord-280878-1kt51viz	406	7	an	an	DT
cord-280878-1kt51viz	406	8	increase	increase	NN
cord-280878-1kt51viz	406	9	in	in	IN
cord-280878-1kt51viz	406	10	membrane	membrane	NN
cord-280878-1kt51viz	406	11	permeability	permeability	NN
cord-280878-1kt51viz	406	12	,	,	,
cord-280878-1kt51viz	406	13	whereas	whereas	IN
cord-280878-1kt51viz	406	14	in	in	IN
cord-280878-1kt51viz	406	15	eukaryotic	eukaryotic	JJ
cord-280878-1kt51viz	406	16	cells	cell	NNS
cord-280878-1kt51viz	406	17	it	-PRON-	PRP
cord-280878-1kt51viz	406	18	promoted	promote	VBD
cord-280878-1kt51viz	406	19	viral	viral	JJ
cord-280878-1kt51viz	406	20	budding	budding	NN
cord-280878-1kt51viz	406	21	(	(	-LRB-
cord-280878-1kt51viz	406	22	Sanz	Sanz	NNP
cord-280878-1kt51viz	406	23	,	,	,
cord-280878-1kt51viz	406	24	Perez	Perez	NNP
cord-280878-1kt51viz	406	25	,	,	,
cord-280878-1kt51viz	406	26	&	&	CC
cord-280878-1kt51viz	406	27	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	406	28	,	,	,
cord-280878-1kt51viz	406	29	1994	1994	CD
cord-280878-1kt51viz	406	30	)	)	-RRB-
cord-280878-1kt51viz	406	31	.	.	.
cord-280878-1kt51viz	407	1	Further	further	RB
cord-280878-1kt51viz	407	2	,	,	,
cord-280878-1kt51viz	407	3	6	6	CD
cord-280878-1kt51viz	407	4	K	k	NN
cord-280878-1kt51viz	407	5	proteins	protein	NNS
cord-280878-1kt51viz	407	6	of	of	IN
cord-280878-1kt51viz	407	7	RRV	RRV	NNP
cord-280878-1kt51viz	407	8	and	and	CC
cord-280878-1kt51viz	407	9	BFV	BFV	NNP
cord-280878-1kt51viz	407	10	formed	form	VBD
cord-280878-1kt51viz	407	11	cationselective	cationselective	JJ
cord-280878-1kt51viz	407	12	ion	ion	NN
cord-280878-1kt51viz	407	13	channels	channel	NNS
cord-280878-1kt51viz	407	14	in	in	IN
cord-280878-1kt51viz	407	15	planar	planar	JJ
cord-280878-1kt51viz	407	16	lipid	lipid	NN
cord-280878-1kt51viz	407	17	bilayers	bilayer	NNS
cord-280878-1kt51viz	407	18	(	(	-LRB-
cord-280878-1kt51viz	407	19	Melton	Melton	NNP
cord-280878-1kt51viz	407	20	et	et	NNP
cord-280878-1kt51viz	407	21	al	al	NNP
cord-280878-1kt51viz	407	22	.	.	NNP
cord-280878-1kt51viz	407	23	,	,	,
cord-280878-1kt51viz	407	24	2002	2002	CD
cord-280878-1kt51viz	407	25	)	)	-RRB-
cord-280878-1kt51viz	407	26	.	.	.
cord-280878-1kt51viz	408	1	This	this	DT
cord-280878-1kt51viz	408	2	suggested	suggest	VBD
cord-280878-1kt51viz	408	3	a	a	DT
cord-280878-1kt51viz	408	4	role	role	NN
cord-280878-1kt51viz	408	5	for	for	IN
cord-280878-1kt51viz	408	6	viroporins	viroporin	NNS
cord-280878-1kt51viz	408	7	in	in	IN
cord-280878-1kt51viz	408	8	alphavirus	alphavirus	NNP
cord-280878-1kt51viz	408	9	infection	infection	NN
cord-280878-1kt51viz	408	10	,	,	,
cord-280878-1kt51viz	408	11	since	since	IN
cord-280878-1kt51viz	408	12	an	an	DT
cord-280878-1kt51viz	408	13	increased	increase	VBN
cord-280878-1kt51viz	408	14	permeability	permeability	NN
cord-280878-1kt51viz	408	15	of	of	IN
cord-280878-1kt51viz	408	16	cells	cell	NNS
cord-280878-1kt51viz	408	17	to	to	IN
cord-280878-1kt51viz	408	18	monovalent	monovalent	JJ
cord-280878-1kt51viz	408	19	cations	cation	NNS
cord-280878-1kt51viz	408	20	is	be	VBZ
cord-280878-1kt51viz	408	21	followed	follow	VBN
cord-280878-1kt51viz	408	22	by	by	IN
cord-280878-1kt51viz	408	23	budding	bud	VBG
cord-280878-1kt51viz	408	24	of	of	IN
cord-280878-1kt51viz	408	25	virions	virion	NNS
cord-280878-1kt51viz	408	26	.	.	.
cord-280878-1kt51viz	409	1	Whatever	whatever	WDT
cord-280878-1kt51viz	409	2	the	the	DT
cord-280878-1kt51viz	409	3	mechanism	mechanism	NN
cord-280878-1kt51viz	409	4	,	,	,
cord-280878-1kt51viz	409	5	6	6	CD
cord-280878-1kt51viz	409	6	K	k	NN
cord-280878-1kt51viz	409	7	proteins	protein	NNS
cord-280878-1kt51viz	409	8	have	have	VBP
cord-280878-1kt51viz	409	9	an	an	DT
cord-280878-1kt51viz	409	10	important	important	JJ
cord-280878-1kt51viz	409	11	role	role	NN
cord-280878-1kt51viz	409	12	in	in	IN
cord-280878-1kt51viz	409	13	virus	virus	NN
cord-280878-1kt51viz	409	14	assembly	assembly	NN
cord-280878-1kt51viz	409	15	and	and	CC
cord-280878-1kt51viz	409	16	budding	budding	NN
cord-280878-1kt51viz	409	17	.	.	.
cord-280878-1kt51viz	410	1	For	for	IN
cord-280878-1kt51viz	410	2	example	example	NN
cord-280878-1kt51viz	410	3	,	,	,
cord-280878-1kt51viz	410	4	in	in	IN
cord-280878-1kt51viz	410	5	Sindbis	Sindbis	NNP
cord-280878-1kt51viz	410	6	virus	virus	NN
cord-280878-1kt51viz	410	7	,	,	,
cord-280878-1kt51viz	410	8	cysteine	cysteine	NN
cord-280878-1kt51viz	410	9	-	-	HYPH
cord-280878-1kt51viz	410	10	less	less	JJR
cord-280878-1kt51viz	410	11	mutants	mutant	NNS
cord-280878-1kt51viz	410	12	dramatically	dramatically	RB
cord-280878-1kt51viz	410	13	reduced	reduce	VBD
cord-280878-1kt51viz	410	14	the	the	DT
cord-280878-1kt51viz	410	15	release	release	NN
cord-280878-1kt51viz	410	16	of	of	IN
cord-280878-1kt51viz	410	17	virus	virus	NN
cord-280878-1kt51viz	410	18	particles	particle	NNS
cord-280878-1kt51viz	410	19	,	,	,
cord-280878-1kt51viz	410	20	leading	lead	VBG
cord-280878-1kt51viz	410	21	to	to	IN
cord-280878-1kt51viz	410	22	aberrant	aberrant	JJ
cord-280878-1kt51viz	410	23	enveloped	enveloped	JJ
cord-280878-1kt51viz	410	24	particles	particle	NNS
cord-280878-1kt51viz	410	25	containing	contain	VBG
cord-280878-1kt51viz	410	26	multiple	multiple	JJ
cord-280878-1kt51viz	410	27	nucleocapsids	nucleocapsid	NNS
cord-280878-1kt51viz	410	28	(	(	-LRB-
cord-280878-1kt51viz	410	29	Gaedigk	Gaedigk	NNP
cord-280878-1kt51viz	410	30	-	-	HYPH
cord-280878-1kt51viz	410	31	Nitschko	Nitschko	NNP
cord-280878-1kt51viz	410	32	,	,	,
cord-280878-1kt51viz	410	33	Ding	Ding	NNP
cord-280878-1kt51viz	410	34	,	,	,
cord-280878-1kt51viz	410	35	Levy	Levy	NNP
cord-280878-1kt51viz	410	36	,	,	,
cord-280878-1kt51viz	410	37	&	&	CC
cord-280878-1kt51viz	410	38	Schlesinger	Schlesinger	NNP
cord-280878-1kt51viz	410	39	,	,	,
cord-280878-1kt51viz	410	40	1990	1990	CD
cord-280878-1kt51viz	410	41	)	)	-RRB-
cord-280878-1kt51viz	410	42	.	.	.
cord-280878-1kt51viz	411	1	Other	other	JJ
cord-280878-1kt51viz	411	2	results	result	NNS
cord-280878-1kt51viz	411	3	are	be	VBP
cord-280878-1kt51viz	411	4	consistent	consistent	JJ
cord-280878-1kt51viz	411	5	with	with	IN
cord-280878-1kt51viz	411	6	an	an	DT
cord-280878-1kt51viz	411	7	indirect	indirect	JJ
cord-280878-1kt51viz	411	8	role	role	NN
cord-280878-1kt51viz	411	9	in	in	IN
cord-280878-1kt51viz	411	10	the	the	DT
cord-280878-1kt51viz	411	11	packing	packing	NN
cord-280878-1kt51viz	411	12	of	of	IN
cord-280878-1kt51viz	411	13	the	the	DT
cord-280878-1kt51viz	411	14	virus	virus	NN
cord-280878-1kt51viz	411	15	spike	spike	NN
cord-280878-1kt51viz	411	16	glycoproteins	glycoprotein	NNS
cord-280878-1kt51viz	411	17	;	;	:
cord-280878-1kt51viz	411	18	mutation	mutation	NN
cord-280878-1kt51viz	411	19	C39S	C39S	NNP
cord-280878-1kt51viz	411	20	resulted	result	VBD
cord-280878-1kt51viz	411	21	in	in	IN
cord-280878-1kt51viz	411	22	defective	defective	JJ
cord-280878-1kt51viz	411	23	budding	budding	NN
cord-280878-1kt51viz	411	24	and	and	CC
cord-280878-1kt51viz	411	25	a	a	DT
cord-280878-1kt51viz	411	26	revertant	revertant	NN
cord-280878-1kt51viz	411	27	contained	contain	VBN
cord-280878-1kt51viz	411	28	two	two	CD
cord-280878-1kt51viz	411	29	additional	additional	JJ
cord-280878-1kt51viz	411	30	mutations	mutation	NNS
cord-280878-1kt51viz	411	31	at	at	IN
cord-280878-1kt51viz	411	32	the	the	DT
cord-280878-1kt51viz	411	33	ectodomain	ectodomain	NN
cord-280878-1kt51viz	411	34	of	of	IN
cord-280878-1kt51viz	411	35	the	the	DT
cord-280878-1kt51viz	411	36	virus	virus	NN
cord-280878-1kt51viz	411	37	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	411	38	(	(	-LRB-
cord-280878-1kt51viz	411	39	Ivanova	Ivanova	NNP
cord-280878-1kt51viz	411	40	,	,	,
cord-280878-1kt51viz	411	41	Lustig	Lustig	NNP
cord-280878-1kt51viz	411	42	,	,	,
cord-280878-1kt51viz	411	43	&	&	CC
cord-280878-1kt51viz	411	44	Schlesinger	Schlesinger	NNP
cord-280878-1kt51viz	411	45	,	,	,
cord-280878-1kt51viz	411	46	1995	1995	CD
cord-280878-1kt51viz	411	47	)	)	-RRB-
cord-280878-1kt51viz	411	48	.	.	.
cord-280878-1kt51viz	412	1	Further	further	RB
cord-280878-1kt51viz	412	2	,	,	,
cord-280878-1kt51viz	412	3	deletion	deletion	NN
cord-280878-1kt51viz	412	4	of	of	IN
cord-280878-1kt51viz	412	5	6	6	CD
cord-280878-1kt51viz	412	6	K	k	NN
cord-280878-1kt51viz	412	7	in	in	IN
cord-280878-1kt51viz	412	8	a	a	DT
cord-280878-1kt51viz	412	9	full	full	JJ
cord-280878-1kt51viz	412	10	-	-	HYPH
cord-280878-1kt51viz	412	11	length	length	NN
cord-280878-1kt51viz	412	12	cDNA	cdna	NN
cord-280878-1kt51viz	412	13	clone	clone	NN
cord-280878-1kt51viz	412	14	of	of	IN
cord-280878-1kt51viz	412	15	SFV	SFV	NNP
cord-280878-1kt51viz	412	16	resulted	result	VBD
cord-280878-1kt51viz	412	17	in	in	IN
cord-280878-1kt51viz	412	18	a	a	DT
cord-280878-1kt51viz	412	19	dramatic	dramatic	JJ
cord-280878-1kt51viz	412	20	reduction	reduction	NN
cord-280878-1kt51viz	412	21	in	in	IN
cord-280878-1kt51viz	412	22	virus	virus	NN
cord-280878-1kt51viz	412	23	release	release	NN
cord-280878-1kt51viz	412	24	(	(	-LRB-
cord-280878-1kt51viz	412	25	Liljestrom	Liljestrom	NNP
cord-280878-1kt51viz	412	26	,	,	,
cord-280878-1kt51viz	412	27	Lusa	Lusa	NNP
cord-280878-1kt51viz	412	28	,	,	,
cord-280878-1kt51viz	412	29	Huylebroeck	Huylebroeck	NNP
cord-280878-1kt51viz	412	30	,	,	,
cord-280878-1kt51viz	412	31	&	&	CC
cord-280878-1kt51viz	412	32	Garoff	Garoff	NNP
cord-280878-1kt51viz	412	33	,	,	,
cord-280878-1kt51viz	412	34	1991	1991	CD
cord-280878-1kt51viz	412	35	)	)	-RRB-
cord-280878-1kt51viz	412	36	,	,	,
cord-280878-1kt51viz	412	37	and	and	CC
cord-280878-1kt51viz	412	38	BHK	BHK	NNP
cord-280878-1kt51viz	412	39	cells	cell	NNS
cord-280878-1kt51viz	412	40	expressing	express	VBG
cord-280878-1kt51viz	412	41	a	a	DT
cord-280878-1kt51viz	412	42	Δ6	Δ6	NNP
cord-280878-1kt51viz	412	43	K	K	NNP
cord-280878-1kt51viz	412	44	strain	strain	NN
cord-280878-1kt51viz	412	45	produced	produce	VBD
cord-280878-1kt51viz	412	46	thermolabile	thermolabile	NN
cord-280878-1kt51viz	412	47	particles	particle	NNS
cord-280878-1kt51viz	412	48	,	,	,
cord-280878-1kt51viz	412	49	suggesting	suggest	VBG
cord-280878-1kt51viz	412	50	a	a	DT
cord-280878-1kt51viz	412	51	disrupted	disrupt	VBN
cord-280878-1kt51viz	412	52	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	412	53	packing	packing	NN
cord-280878-1kt51viz	412	54	(	(	-LRB-
cord-280878-1kt51viz	412	55	Loewy	Loewy	NNP
cord-280878-1kt51viz	412	56	,	,	,
cord-280878-1kt51viz	412	57	Smyth	Smyth	NNP
cord-280878-1kt51viz	412	58	,	,	,
cord-280878-1kt51viz	412	59	von	von	NNP
cord-280878-1kt51viz	412	60	Bonsdorff	Bonsdorff	NNP
cord-280878-1kt51viz	412	61	,	,	,
cord-280878-1kt51viz	412	62	Liljestrom	Liljestrom	NNP
cord-280878-1kt51viz	412	63	,	,	,
cord-280878-1kt51viz	412	64	&	&	CC
cord-280878-1kt51viz	412	65	Schlesinger	Schlesinger	NNP
cord-280878-1kt51viz	412	66	,	,	,
cord-280878-1kt51viz	412	67	1995	1995	CD
cord-280878-1kt51viz	412	68	)	)	-RRB-
cord-280878-1kt51viz	412	69	.	.	.
cord-280878-1kt51viz	413	1	Despite	despite	IN
cord-280878-1kt51viz	413	2	these	these	DT
cord-280878-1kt51viz	413	3	investigations	investigation	NNS
cord-280878-1kt51viz	413	4	,	,	,
cord-280878-1kt51viz	413	5	the	the	DT
cord-280878-1kt51viz	413	6	specific	specific	JJ
cord-280878-1kt51viz	413	7	role	role	NN
cord-280878-1kt51viz	413	8	of	of	IN
cord-280878-1kt51viz	413	9	6	6	CD
cord-280878-1kt51viz	413	10	K	k	NN
cord-280878-1kt51viz	413	11	channel	channel	NN
cord-280878-1kt51viz	413	12	activity	activity	NN
cord-280878-1kt51viz	413	13	in	in	IN
cord-280878-1kt51viz	413	14	these	these	DT
cord-280878-1kt51viz	413	15	processes	process	NNS
cord-280878-1kt51viz	413	16	is	be	VBZ
cord-280878-1kt51viz	413	17	still	still	RB
cord-280878-1kt51viz	413	18	uncertain	uncertain	JJ
cord-280878-1kt51viz	413	19	.	.	.
cord-280878-1kt51viz	414	1	Agnoprotein	Agnoprotein	NNP
cord-280878-1kt51viz	414	2	is	be	VBZ
cord-280878-1kt51viz	414	3	a	a	DT
cord-280878-1kt51viz	414	4	71-amino	71-amino	CD
cord-280878-1kt51viz	414	5	acids	acid	NNS
cord-280878-1kt51viz	414	6	long	long	JJ
cord-280878-1kt51viz	414	7	membrane	membrane	NN
cord-280878-1kt51viz	414	8	protein	protein	NN
cord-280878-1kt51viz	414	9	with	with	IN
cord-280878-1kt51viz	414	10	one	one	CD
cord-280878-1kt51viz	415	1	predicted	predict	VBD
cord-280878-1kt51viz	415	2	α	α	NN
cord-280878-1kt51viz	415	3	-	-	HYPH
cord-280878-1kt51viz	415	4	helical	helical	JJ
cord-280878-1kt51viz	415	5	TM	TM	NNP
cord-280878-1kt51viz	415	6	domain	domain	NN
cord-280878-1kt51viz	415	7	required	require	VBN
cord-280878-1kt51viz	415	8	for	for	IN
cord-280878-1kt51viz	415	9	the	the	DT
cord-280878-1kt51viz	415	10	productive	productive	JJ
cord-280878-1kt51viz	415	11	replication	replication	NN
cord-280878-1kt51viz	415	12	of	of	IN
cord-280878-1kt51viz	415	13	the	the	DT
cord-280878-1kt51viz	415	14	human	human	JJ
cord-280878-1kt51viz	415	15	polyomavirus	polyomavirus	JJ
cord-280878-1kt51viz	415	16	JCV	JCV	NNP
cord-280878-1kt51viz	415	17	(	(	-LRB-
cord-280878-1kt51viz	415	18	John	John	NNP
cord-280878-1kt51viz	415	19	Cunningham	Cunningham	NNP
cord-280878-1kt51viz	415	20	virus	virus	NN
cord-280878-1kt51viz	415	21	)	)	-RRB-
cord-280878-1kt51viz	415	22	.	.	.
cord-280878-1kt51viz	416	1	JCV	JCV	NNP
cord-280878-1kt51viz	416	2	causes	cause	VBZ
cord-280878-1kt51viz	416	3	progressive	progressive	JJ
cord-280878-1kt51viz	416	4	multifocal	multifocal	JJ
cord-280878-1kt51viz	416	5	leukoencephalopathy	leukoencephalopathy	NNP
cord-280878-1kt51viz	416	6	,	,	,
cord-280878-1kt51viz	416	7	a	a	DT
cord-280878-1kt51viz	416	8	fatal	fatal	JJ
cord-280878-1kt51viz	416	9	demyelinating	demyelinating	NN
cord-280878-1kt51viz	416	10	disease	disease	NN
cord-280878-1kt51viz	416	11	resulting	result	VBG
cord-280878-1kt51viz	416	12	from	from	IN
cord-280878-1kt51viz	416	13	lytic	lytic	JJ
cord-280878-1kt51viz	416	14	infection	infection	NN
cord-280878-1kt51viz	416	15	of	of	IN
cord-280878-1kt51viz	416	16	oligodendrocytes	oligodendrocyte	NNS
cord-280878-1kt51viz	416	17	.	.	.
cord-280878-1kt51viz	417	1	Agnoproteinis	Agnoproteinis	NNP
cord-280878-1kt51viz	417	2	also	also	RB
cord-280878-1kt51viz	417	3	found	find	VBD
cord-280878-1kt51viz	417	4	in	in	IN
cord-280878-1kt51viz	417	5	other	other	JJ
cord-280878-1kt51viz	417	6	polyomaviruses	polyomaviruse	NNS
cord-280878-1kt51viz	417	7	,	,	,
cord-280878-1kt51viz	417	8	including	include	VBG
cord-280878-1kt51viz	417	9	BK	BK	NNP
cord-280878-1kt51viz	417	10	virus	virus	NN
cord-280878-1kt51viz	417	11	,	,	,
cord-280878-1kt51viz	417	12	and	and	CC
cord-280878-1kt51viz	417	13	simian	simian	JJ
cord-280878-1kt51viz	417	14	virus	virus	NN
cord-280878-1kt51viz	417	15	40	40	CD
cord-280878-1kt51viz	418	1	(	(	-LRB-
cord-280878-1kt51viz	418	2	Sariyer	Sariyer	NNP
cord-280878-1kt51viz	418	3	,	,	,
cord-280878-1kt51viz	418	4	Saribas	Saribas	NNP
cord-280878-1kt51viz	418	5	,	,	,
cord-280878-1kt51viz	418	6	White	White	NNP
cord-280878-1kt51viz	418	7	,	,	,
cord-280878-1kt51viz	418	8	&	&	CC
cord-280878-1kt51viz	418	9	Safak	Safak	NNP
cord-280878-1kt51viz	418	10	,	,	,
cord-280878-1kt51viz	418	11	2011	2011	CD
cord-280878-1kt51viz	418	12	)	)	-RRB-
cord-280878-1kt51viz	418	13	.	.	.
cord-280878-1kt51viz	419	1	Agnoprotein	Agnoprotein	NNP
cord-280878-1kt51viz	419	2	was	be	VBD
cord-280878-1kt51viz	419	3	shown	show	VBN
cord-280878-1kt51viz	419	4	to	to	TO
cord-280878-1kt51viz	419	5	play	play	VB
cord-280878-1kt51viz	419	6	important	important	JJ
cord-280878-1kt51viz	419	7	regulatory	regulatory	JJ
cord-280878-1kt51viz	419	8	roles	role	NNS
cord-280878-1kt51viz	419	9	in	in	IN
cord-280878-1kt51viz	419	10	the	the	DT
cord-280878-1kt51viz	419	11	JCV	JCV	NNP
cord-280878-1kt51viz	419	12	replication	replication	NN
cord-280878-1kt51viz	419	13	cycle	cycle	NN
cord-280878-1kt51viz	419	14	(	(	-LRB-
cord-280878-1kt51viz	419	15	Ellis	Ellis	NNP
cord-280878-1kt51viz	419	16	,	,	,
cord-280878-1kt51viz	419	17	Dang	Dang	NNP
cord-280878-1kt51viz	419	18	,	,	,
cord-280878-1kt51viz	419	19	Norton	Norton	NNP
cord-280878-1kt51viz	419	20	,	,	,
cord-280878-1kt51viz	419	21	&	&	CC
cord-280878-1kt51viz	419	22	Koralnik	Koralnik	NNP
cord-280878-1kt51viz	419	23	,	,	,
cord-280878-1kt51viz	419	24	2012	2012	CD
cord-280878-1kt51viz	419	25	;	;	:
cord-280878-1kt51viz	419	26	Ellis	Ellis	NNP
cord-280878-1kt51viz	419	27	,	,	,
cord-280878-1kt51viz	419	28	Norton	Norton	NNP
cord-280878-1kt51viz	419	29	,	,	,
cord-280878-1kt51viz	419	30	Dang	Dang	NNP
cord-280878-1kt51viz	419	31	,	,	,
cord-280878-1kt51viz	419	32	&	&	CC
cord-280878-1kt51viz	419	33	Koralnik	Koralnik	NNP
cord-280878-1kt51viz	419	34	,	,	,
cord-280878-1kt51viz	419	35	2013	2013	CD
cord-280878-1kt51viz	419	36	;	;	:
cord-280878-1kt51viz	419	37	Saribas	Saribas	NNP
cord-280878-1kt51viz	419	38	et	et	FW
cord-280878-1kt51viz	419	39	al	al	NNP
cord-280878-1kt51viz	419	40	.	.	NNP
cord-280878-1kt51viz	419	41	,	,	,
cord-280878-1kt51viz	419	42	2013	2013	CD
cord-280878-1kt51viz	419	43	)	)	-RRB-
cord-280878-1kt51viz	419	44	,	,	,
cord-280878-1kt51viz	419	45	and	and	CC
cord-280878-1kt51viz	419	46	possesses	possess	VBZ
cord-280878-1kt51viz	419	47	properties	property	NNS
cord-280878-1kt51viz	419	48	commonly	commonly	RB
cord-280878-1kt51viz	419	49	associated	associate	VBN
cord-280878-1kt51viz	419	50	with	with	IN
cord-280878-1kt51viz	419	51	viroporins	viroporin	NNS
cord-280878-1kt51viz	419	52	(	(	-LRB-
cord-280878-1kt51viz	419	53	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	419	54	et	et	FW
cord-280878-1kt51viz	419	55	al	al	NNP
cord-280878-1kt51viz	419	56	.	.	NNP
cord-280878-1kt51viz	419	57	,	,	,
cord-280878-1kt51viz	419	58	2013	2013	CD
cord-280878-1kt51viz	419	59	;	;	:
cord-280878-1kt51viz	419	60	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	419	61	,	,	,
cord-280878-1kt51viz	419	62	Orba	Orba	NNP
cord-280878-1kt51viz	419	63	,	,	,
cord-280878-1kt51viz	419	64	Malcino	Malcino	NNP
cord-280878-1kt51viz	419	65	,	,	,
cord-280878-1kt51viz	419	66	et	et	NNP
cord-280878-1kt51viz	419	67	al	al	NNP
cord-280878-1kt51viz	419	68	.	.	NNP
cord-280878-1kt51viz	419	69	,	,	,
cord-280878-1kt51viz	419	70	2010	2010	CD
cord-280878-1kt51viz	419	71	;	;	:
cord-280878-1kt51viz	419	72	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	419	73	,	,	,
cord-280878-1kt51viz	419	74	Orba	Orba	NNP
cord-280878-1kt51viz	419	75	,	,	,
cord-280878-1kt51viz	419	76	Okada	Okada	NNP
cord-280878-1kt51viz	419	77	,	,	,
cord-280878-1kt51viz	419	78	et	et	NNP
cord-280878-1kt51viz	419	79	al	al	NNP
cord-280878-1kt51viz	419	80	.	.	NNP
cord-280878-1kt51viz	419	81	,	,	,
cord-280878-1kt51viz	419	82	2010	2010	CD
cord-280878-1kt51viz	419	83	)	)	-RRB-
cord-280878-1kt51viz	419	84	.	.	.
cord-280878-1kt51viz	420	1	For	for	IN
cord-280878-1kt51viz	420	2	example	example	NN
cord-280878-1kt51viz	420	3	,	,	,
cord-280878-1kt51viz	420	4	a	a	DT
cord-280878-1kt51viz	420	5	deletion	deletion	NN
cord-280878-1kt51viz	420	6	mutant	mutant	NN
cord-280878-1kt51viz	420	7	is	be	VBZ
cord-280878-1kt51viz	420	8	defective	defective	JJ
cord-280878-1kt51viz	420	9	in	in	IN
cord-280878-1kt51viz	420	10	virion	virion	NN
cord-280878-1kt51viz	420	11	release	release	NN
cord-280878-1kt51viz	420	12	and	and	CC
cord-280878-1kt51viz	420	13	viral	viral	JJ
cord-280878-1kt51viz	420	14	propagation	propagation	NN
cord-280878-1kt51viz	420	15	.	.	.
cord-280878-1kt51viz	421	1	Also	also	RB
cord-280878-1kt51viz	421	2	,	,	,
cord-280878-1kt51viz	421	3	agnoprotein	agnoprotein	RB
cord-280878-1kt51viz	421	4	localizes	localize	VBZ
cord-280878-1kt51viz	421	5	to	to	IN
cord-280878-1kt51viz	421	6	the	the	DT
cord-280878-1kt51viz	421	7	ER	ER	NNP
cord-280878-1kt51viz	421	8	during	during	IN
cord-280878-1kt51viz	421	9	early	early	JJ
cord-280878-1kt51viz	421	10	stages	stage	NNS
cord-280878-1kt51viz	421	11	of	of	IN
cord-280878-1kt51viz	421	12	infection	infection	NN
cord-280878-1kt51viz	421	13	,	,	,
cord-280878-1kt51viz	421	14	but	but	CC
cord-280878-1kt51viz	421	15	is	be	VBZ
cord-280878-1kt51viz	421	16	also	also	RB
cord-280878-1kt51viz	421	17	found	find	VBN
cord-280878-1kt51viz	421	18	at	at	IN
cord-280878-1kt51viz	421	19	the	the	DT
cord-280878-1kt51viz	421	20	plasma	plasma	NN
cord-280878-1kt51viz	421	21	membrane	membrane	NN
cord-280878-1kt51viz	421	22	late	late	RB
cord-280878-1kt51viz	421	23	in	in	IN
cord-280878-1kt51viz	421	24	infection	infection	NN
cord-280878-1kt51viz	421	25	.	.	.
cord-280878-1kt51viz	422	1	Finally	finally	RB
cord-280878-1kt51viz	422	2	,	,	,
cord-280878-1kt51viz	422	3	agnoprotein	agnoprotein	RB
cord-280878-1kt51viz	422	4	,	,	,
cord-280878-1kt51viz	422	5	an	an	DT
cord-280878-1kt51viz	422	6	integral	integral	JJ
cord-280878-1kt51viz	422	7	membrane	membrane	NN
cord-280878-1kt51viz	422	8	protein	protein	NN
cord-280878-1kt51viz	422	9	,	,	,
cord-280878-1kt51viz	422	10	forms	form	VBZ
cord-280878-1kt51viz	422	11	homo	homo	NN
cord-280878-1kt51viz	422	12	-	-	HYPH
cord-280878-1kt51viz	422	13	oligomers	oligomer	NNS
cord-280878-1kt51viz	422	14	that	that	WDT
cord-280878-1kt51viz	422	15	enhance	enhance	VBP
cord-280878-1kt51viz	422	16	permeability	permeability	NN
cord-280878-1kt51viz	422	17	of	of	IN
cord-280878-1kt51viz	422	18	cells	cell	NNS
cord-280878-1kt51viz	422	19	to	to	IN
cord-280878-1kt51viz	422	20	hygromycin	hygromycin	NNS
cord-280878-1kt51viz	422	21	B	B	NNP
cord-280878-1kt51viz	422	22	and	and	CC
cord-280878-1kt51viz	422	23	induce	induce	VB
cord-280878-1kt51viz	422	24	the	the	DT
cord-280878-1kt51viz	422	25	influx	influx	NN
cord-280878-1kt51viz	422	26	of	of	IN
cord-280878-1kt51viz	423	1	extracellular	extracellular	JJ
cord-280878-1kt51viz	423	2	Ca	Ca	NNP
cord-280878-1kt51viz	423	3	2	2	CD
cord-280878-1kt51viz	423	4	+	+	CC
cord-280878-1kt51viz	423	5	,	,	,
cord-280878-1kt51viz	423	6	leading	lead	VBG
cord-280878-1kt51viz	423	7	to	to	IN
cord-280878-1kt51viz	423	8	membrane	membrane	NN
cord-280878-1kt51viz	423	9	dysfunction	dysfunction	NN
cord-280878-1kt51viz	423	10	and	and	CC
cord-280878-1kt51viz	423	11	enhancement	enhancement	NN
cord-280878-1kt51viz	423	12	of	of	IN
cord-280878-1kt51viz	423	13	virus	virus	NN
cord-280878-1kt51viz	423	14	release	release	NN
cord-280878-1kt51viz	423	15	.	.	.
cord-280878-1kt51viz	424	1	Only	only	RB
cord-280878-1kt51viz	424	2	a	a	DT
cord-280878-1kt51viz	424	3	solution	solution	NN
cord-280878-1kt51viz	424	4	NMR	NMR	NNP
cord-280878-1kt51viz	424	5	structure	structure	NN
cord-280878-1kt51viz	424	6	of	of	IN
cord-280878-1kt51viz	424	7	a	a	DT
cord-280878-1kt51viz	424	8	synthetic	synthetic	JJ
cord-280878-1kt51viz	424	9	peptide	peptide	NN
cord-280878-1kt51viz	424	10	corresponding	correspond	VBG
cord-280878-1kt51viz	424	11	to	to	IN
cord-280878-1kt51viz	424	12	the	the	DT
cord-280878-1kt51viz	424	13	TM	TM	NNP
cord-280878-1kt51viz	424	14	domain	domain	NN
cord-280878-1kt51viz	424	15	(	(	-LRB-
cord-280878-1kt51viz	424	16	Thr-17	Thr-17	NNP
cord-280878-1kt51viz	424	17	to	to	IN
cord-280878-1kt51viz	424	18	Glu-55	Glu-55	NNP
cord-280878-1kt51viz	424	19	)	)	-RRB-
cord-280878-1kt51viz	424	20	is	be	VBZ
cord-280878-1kt51viz	424	21	available	available	JJ
cord-280878-1kt51viz	424	22	,	,	,
cord-280878-1kt51viz	424	23	but	but	CC
cord-280878-1kt51viz	424	24	with	with	IN
cord-280878-1kt51viz	424	25	an	an	DT
cord-280878-1kt51viz	424	26	uncertain	uncertain	JJ
cord-280878-1kt51viz	424	27	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	424	28	size	size	NN
cord-280878-1kt51viz	424	29	in	in	IN
cord-280878-1kt51viz	424	30	lipid	lipid	NN
cord-280878-1kt51viz	424	31	bilayers	bilayer	NNS
cord-280878-1kt51viz	424	32	(	(	-LRB-
cord-280878-1kt51viz	424	33	Coric	Coric	NNP
cord-280878-1kt51viz	424	34	et	et	NNP
cord-280878-1kt51viz	424	35	al	al	NNP
cord-280878-1kt51viz	424	36	.	.	NNP
cord-280878-1kt51viz	424	37	,	,	,
cord-280878-1kt51viz	424	38	2014	2014	CD
cord-280878-1kt51viz	424	39	)	)	-RRB-
cord-280878-1kt51viz	424	40	.	.	.
cord-280878-1kt51viz	425	1	As	as	IN
cord-280878-1kt51viz	425	2	with	with	IN
cord-280878-1kt51viz	425	3	the	the	DT
cord-280878-1kt51viz	425	4	6	6	CD
cord-280878-1kt51viz	425	5	K	K	NNP
cord-280878-1kt51viz	425	6	protein	protein	NN
cord-280878-1kt51viz	425	7	,	,	,
cord-280878-1kt51viz	425	8	characterization	characterization	NN
cord-280878-1kt51viz	425	9	of	of	IN
cord-280878-1kt51viz	425	10	this	this	DT
cord-280878-1kt51viz	425	11	viroporin	viroporin	NN
cord-280878-1kt51viz	425	12	is	be	VBZ
cord-280878-1kt51viz	425	13	still	still	RB
cord-280878-1kt51viz	425	14	in	in	IN
cord-280878-1kt51viz	425	15	its	-PRON-	PRP$
cord-280878-1kt51viz	425	16	infancy	infancy	NN
cord-280878-1kt51viz	425	17	.	.	.
cord-280878-1kt51viz	426	1	Protein	protein	NN
cord-280878-1kt51viz	426	2	2B	2b	CD
cord-280878-1kt51viz	426	3	is	be	VBZ
cord-280878-1kt51viz	426	4	a	a	DT
cord-280878-1kt51viz	426	5	$	$	$
cord-280878-1kt51viz	426	6	100	100	CD
cord-280878-1kt51viz	426	7	residues	residue	NNS
cord-280878-1kt51viz	426	8	long	long	JJ
cord-280878-1kt51viz	426	9	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	426	10	protein	protein	NN
cord-280878-1kt51viz	426	11	found	find	VBN
cord-280878-1kt51viz	426	12	in	in	IN
cord-280878-1kt51viz	426	13	enteroviruses	enteroviruses	NNP
cord-280878-1kt51viz	426	14	[	[	-LRB-
cord-280878-1kt51viz	426	15	see	see	VB
cord-280878-1kt51viz	426	16	Ao	Ao	NNP
cord-280878-1kt51viz	426	17	,	,	,
cord-280878-1kt51viz	426	18	Sun	Sun	NNP
cord-280878-1kt51viz	426	19	,	,	,
cord-280878-1kt51viz	426	20	&	&	CC
cord-280878-1kt51viz	426	21	Guo	Guo	NNP
cord-280878-1kt51viz	426	22	,	,	,
cord-280878-1kt51viz	426	23	2014	2014	CD
cord-280878-1kt51viz	426	24	for	for	IN
cord-280878-1kt51viz	426	25	a	a	DT
cord-280878-1kt51viz	426	26	recent	recent	JJ
cord-280878-1kt51viz	426	27	review	review	NN
cord-280878-1kt51viz	426	28	]	]	-RRB-
cord-280878-1kt51viz	426	29	,	,	,
cord-280878-1kt51viz	426	30	eg	eg	NNS
cord-280878-1kt51viz	426	31	,	,	,
cord-280878-1kt51viz	426	32	poliovirus	poliovirus	NN
cord-280878-1kt51viz	426	33	(	(	-LRB-
cord-280878-1kt51viz	426	34	Agirre	Agirre	NNP
cord-280878-1kt51viz	426	35	,	,	,
cord-280878-1kt51viz	426	36	Barco	Barco	NNP
cord-280878-1kt51viz	426	37	,	,	,
cord-280878-1kt51viz	426	38	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	426	39	,	,	,
cord-280878-1kt51viz	426	40	&	&	CC
cord-280878-1kt51viz	426	41	Nieva	Nieva	NNP
cord-280878-1kt51viz	426	42	,	,	,
cord-280878-1kt51viz	426	43	2002	2002	CD
cord-280878-1kt51viz	426	44	)	)	-RRB-
cord-280878-1kt51viz	426	45	.	.	.
cord-280878-1kt51viz	427	1	Enteroviruses	enterovirus	NNS
cord-280878-1kt51viz	427	2	belong	belong	VBP
cord-280878-1kt51viz	427	3	to	to	IN
cord-280878-1kt51viz	427	4	the	the	DT
cord-280878-1kt51viz	427	5	single	single	RB
cord-280878-1kt51viz	427	6	-	-	HYPH
cord-280878-1kt51viz	427	7	stranded	strand	VBN
cord-280878-1kt51viz	427	8	positive	positive	JJ
cord-280878-1kt51viz	427	9	-	-	HYPH
cord-280878-1kt51viz	427	10	sense	sense	NN
cord-280878-1kt51viz	427	11	RNA	RNA	NNP
cord-280878-1kt51viz	427	12	Picornaviridae	Picornaviridae	NNP
cord-280878-1kt51viz	427	13	family	family	NN
cord-280878-1kt51viz	427	14	,	,	,
cord-280878-1kt51viz	427	15	and	and	CC
cord-280878-1kt51viz	427	16	include	include	VBP
cord-280878-1kt51viz	427	17	poliovirus	poliovirus	NN
cord-280878-1kt51viz	427	18	,	,	,
cord-280878-1kt51viz	427	19	Coxsackie	Coxsackie	NNP
cord-280878-1kt51viz	427	20	virus	virus	NN
cord-280878-1kt51viz	427	21	and	and	CC
cord-280878-1kt51viz	427	22	human	human	JJ
cord-280878-1kt51viz	427	23	enterovirus	enterovirus	NN
cord-280878-1kt51viz	427	24	71	71	CD
cord-280878-1kt51viz	428	1	(	(	-LRB-
cord-280878-1kt51viz	428	2	EV71	EV71	NNP
cord-280878-1kt51viz	428	3	)	)	-RRB-
cord-280878-1kt51viz	428	4	.	.	.
cord-280878-1kt51viz	429	1	The	the	DT
cord-280878-1kt51viz	429	2	single	single	JJ
cord-280878-1kt51viz	429	3	open	open	JJ
cord-280878-1kt51viz	429	4	reading	reading	NN
cord-280878-1kt51viz	429	5	frame	frame	NN
cord-280878-1kt51viz	429	6	encodes	encode	VBZ
cord-280878-1kt51viz	429	7	a	a	DT
cord-280878-1kt51viz	429	8	peptide	peptide	NN
cord-280878-1kt51viz	429	9	chain	chain	NN
cord-280878-1kt51viz	429	10	divided	divide	VBN
cord-280878-1kt51viz	429	11	into	into	IN
cord-280878-1kt51viz	429	12	three	three	CD
cord-280878-1kt51viz	429	13	regions	region	NNS
cord-280878-1kt51viz	429	14	,	,	,
cord-280878-1kt51viz	429	15	P1	P1	NNP
cord-280878-1kt51viz	429	16	to	to	IN
cord-280878-1kt51viz	429	17	P3	P3	NNP
cord-280878-1kt51viz	429	18	.	.	.
cord-280878-1kt51viz	430	1	The	the	DT
cord-280878-1kt51viz	430	2	2B	2b	CD
cord-280878-1kt51viz	430	3	protein	protein	NN
cord-280878-1kt51viz	430	4	is	be	VBZ
cord-280878-1kt51viz	430	5	one	one	CD
cord-280878-1kt51viz	430	6	of	of	IN
cord-280878-1kt51viz	430	7	the	the	DT
cord-280878-1kt51viz	430	8	products	product	NNS
cord-280878-1kt51viz	430	9	from	from	IN
cord-280878-1kt51viz	430	10	the	the	DT
cord-280878-1kt51viz	430	11	polypeptides	polypeptide	NNS
cord-280878-1kt51viz	430	12	in	in	IN
cord-280878-1kt51viz	430	13	the	the	DT
cord-280878-1kt51viz	430	14	P2	P2	NNP
cord-280878-1kt51viz	430	15	region	region	NN
cord-280878-1kt51viz	430	16	,	,	,
cord-280878-1kt51viz	430	17	and	and	CC
cord-280878-1kt51viz	430	18	has	have	VBZ
cord-280878-1kt51viz	430	19	two	two	CD
cord-280878-1kt51viz	430	20	TM	TM	NNP
cord-280878-1kt51viz	430	21	domains	domain	NNS
cord-280878-1kt51viz	430	22	,	,	,
cord-280878-1kt51viz	430	23	one	one	CD
cord-280878-1kt51viz	430	24	more	more	RBR
cord-280878-1kt51viz	430	25	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	430	26	than	than	IN
cord-280878-1kt51viz	430	27	the	the	DT
cord-280878-1kt51viz	430	28	other	other	JJ
cord-280878-1kt51viz	430	29	(	(	-LRB-
cord-280878-1kt51viz	430	30	de	de	FW
cord-280878-1kt51viz	430	31	Jong	Jong	NNP
cord-280878-1kt51viz	430	32	et	et	NNP
cord-280878-1kt51viz	430	33	al	al	NNP
cord-280878-1kt51viz	430	34	.	.	NNP
cord-280878-1kt51viz	430	35	,	,	,
cord-280878-1kt51viz	430	36	2003	2003	CD
cord-280878-1kt51viz	430	37	;	;	:
cord-280878-1kt51viz	430	38	Nieva	Nieva	NNP
cord-280878-1kt51viz	430	39	,	,	,
cord-280878-1kt51viz	430	40	Agirre	Agirre	NNP
cord-280878-1kt51viz	430	41	,	,	,
cord-280878-1kt51viz	430	42	Nir	Nir	NNP
cord-280878-1kt51viz	430	43	,	,	,
cord-280878-1kt51viz	430	44	&	&	CC
cord-280878-1kt51viz	430	45	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	430	46	,	,	,
cord-280878-1kt51viz	430	47	2003	2003	CD
cord-280878-1kt51viz	430	48	)	)	-RRB-
cord-280878-1kt51viz	430	49	.	.	.
cord-280878-1kt51viz	431	1	The	the	DT
cord-280878-1kt51viz	431	2	C	C	NNP
cord-280878-1kt51viz	431	3	-	-	HYPH
cord-280878-1kt51viz	431	4	and	and	CC
cord-280878-1kt51viz	431	5	N	N	NNP
cord-280878-1kt51viz	431	6	-	-	HYPH
cord-280878-1kt51viz	431	7	termini	termini	NNP
cord-280878-1kt51viz	432	1	of	of	IN
cord-280878-1kt51viz	432	2	the	the	DT
cord-280878-1kt51viz	432	3	poliovirus	poliovirus	NN
cord-280878-1kt51viz	432	4	2B	2b	CD
cord-280878-1kt51viz	432	5	protein	protein	NN
cord-280878-1kt51viz	432	6	are	be	VBP
cord-280878-1kt51viz	432	7	exposed	expose	VBN
cord-280878-1kt51viz	432	8	to	to	IN
cord-280878-1kt51viz	432	9	the	the	DT
cord-280878-1kt51viz	432	10	ER	ER	NNP
cord-280878-1kt51viz	432	11	and	and	CC
cord-280878-1kt51viz	432	12	Golgi	Golgi	NNP
cord-280878-1kt51viz	432	13	lumen	lumen	NN
cord-280878-1kt51viz	432	14	when	when	WRB
cord-280878-1kt51viz	432	15	expressed	express	VBN
cord-280878-1kt51viz	432	16	in	in	IN
cord-280878-1kt51viz	432	17	cells	cell	NNS
cord-280878-1kt51viz	432	18	(	(	-LRB-
cord-280878-1kt51viz	432	19	de	de	FW
cord-280878-1kt51viz	432	20	Jong	Jong	NNP
cord-280878-1kt51viz	432	21	et	et	NNP
cord-280878-1kt51viz	432	22	al	al	NNP
cord-280878-1kt51viz	432	23	.	.	NNP
cord-280878-1kt51viz	432	24	,	,	,
cord-280878-1kt51viz	432	25	2003	2003	CD
cord-280878-1kt51viz	432	26	)	)	-RRB-
cord-280878-1kt51viz	432	27	,	,	,
cord-280878-1kt51viz	432	28	but	but	CC
cord-280878-1kt51viz	432	29	the	the	DT
cord-280878-1kt51viz	432	30	2B	2B	NNP
cord-280878-1kt51viz	432	31	protein	protein	NN
cord-280878-1kt51viz	432	32	in	in	IN
cord-280878-1kt51viz	432	33	Coxsackie	Coxsackie	NNP
cord-280878-1kt51viz	432	34	virus	virus	NN
cord-280878-1kt51viz	432	35	adopts	adopt	VBZ
cord-280878-1kt51viz	432	36	an	an	DT
cord-280878-1kt51viz	432	37	opposite	opposite	JJ
cord-280878-1kt51viz	432	38	orientation	orientation	NN
cord-280878-1kt51viz	432	39	(	(	-LRB-
cord-280878-1kt51viz	432	40	Abed	Abed	NNP
cord-280878-1kt51viz	432	41	et	et	NNP
cord-280878-1kt51viz	432	42	al	al	NNP
cord-280878-1kt51viz	432	43	.	.	NNP
cord-280878-1kt51viz	432	44	,	,	,
cord-280878-1kt51viz	432	45	2005	2005	CD
cord-280878-1kt51viz	432	46	,	,	,
cord-280878-1kt51viz	432	47	van	van	NNP
cord-280878-1kt51viz	432	48	Kuppeveld	Kuppeveld	NNP
cord-280878-1kt51viz	432	49	,	,	,
cord-280878-1kt51viz	432	50	Galama	Galama	NNP
cord-280878-1kt51viz	432	51	,	,	,
cord-280878-1kt51viz	432	52	Zoll	Zoll	NNP
cord-280878-1kt51viz	432	53	,	,	,
cord-280878-1kt51viz	432	54	van	van	NNP
cord-280878-1kt51viz	432	55	den	den	NNP
cord-280878-1kt51viz	432	56	Hurk	Hurk	NNP
cord-280878-1kt51viz	432	57	,	,	,
cord-280878-1kt51viz	432	58	&	&	CC
cord-280878-1kt51viz	432	59	Melchers	Melchers	NNP
cord-280878-1kt51viz	432	60	,	,	,
cord-280878-1kt51viz	432	61	1996	1996	CD
cord-280878-1kt51viz	432	62	.	.	.
cord-280878-1kt51viz	433	1	Poliovirus	Poliovirus	NNP
cord-280878-1kt51viz	433	2	2B	2B	NNP
cord-280878-1kt51viz	433	3	protein	protein	NN
cord-280878-1kt51viz	433	4	was	be	VBD
cord-280878-1kt51viz	433	5	found	find	VBN
cord-280878-1kt51viz	433	6	to	to	TO
cord-280878-1kt51viz	433	7	increase	increase	VB
cord-280878-1kt51viz	433	8	the	the	DT
cord-280878-1kt51viz	433	9	concentrations	concentration	NNS
cord-280878-1kt51viz	433	10	of	of	IN
cord-280878-1kt51viz	433	11	free	free	JJ
cord-280878-1kt51viz	433	12	calcium	calcium	NN
cord-280878-1kt51viz	433	13	in	in	IN
cord-280878-1kt51viz	433	14	the	the	DT
cord-280878-1kt51viz	433	15	cytosol	cytosol	NN
cord-280878-1kt51viz	433	16	,	,	,
cord-280878-1kt51viz	433	17	which	which	WDT
cord-280878-1kt51viz	433	18	has	have	VBZ
cord-280878-1kt51viz	433	19	been	be	VBN
cord-280878-1kt51viz	433	20	proposed	propose	VBN
cord-280878-1kt51viz	433	21	to	to	TO
cord-280878-1kt51viz	433	22	promote	promote	VB
cord-280878-1kt51viz	433	23	viral	viral	JJ
cord-280878-1kt51viz	433	24	replication	replication	NN
cord-280878-1kt51viz	433	25	and	and	CC
cord-280878-1kt51viz	433	26	repression	repression	NN
cord-280878-1kt51viz	433	27	of	of	IN
cord-280878-1kt51viz	433	28	the	the	DT
cord-280878-1kt51viz	433	29	antiviral	antiviral	JJ
cord-280878-1kt51viz	433	30	immune	immune	JJ
cord-280878-1kt51viz	433	31	response	response	NN
cord-280878-1kt51viz	433	32	of	of	IN
cord-280878-1kt51viz	433	33	host	host	NN
cord-280878-1kt51viz	433	34	cells	cell	NNS
cord-280878-1kt51viz	433	35	(	(	-LRB-
cord-280878-1kt51viz	433	36	Aldabe	Aldabe	NNP
cord-280878-1kt51viz	433	37	,	,	,
cord-280878-1kt51viz	433	38	Irurzun	Irurzun	NNP
cord-280878-1kt51viz	433	39	,	,	,
cord-280878-1kt51viz	433	40	&	&	CC
cord-280878-1kt51viz	433	41	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	433	42	,	,	,
cord-280878-1kt51viz	433	43	1997	1997	CD
cord-280878-1kt51viz	433	44	)	)	-RRB-
cord-280878-1kt51viz	433	45	.	.	.
cord-280878-1kt51viz	434	1	However	however	RB
cord-280878-1kt51viz	434	2	,	,	,
cord-280878-1kt51viz	434	3	precise	precise	JJ
cord-280878-1kt51viz	434	4	structural	structural	JJ
cord-280878-1kt51viz	434	5	data	data	NN
cord-280878-1kt51viz	434	6	is	be	VBZ
cord-280878-1kt51viz	434	7	not	not	RB
cord-280878-1kt51viz	434	8	yet	yet	RB
cord-280878-1kt51viz	434	9	available	available	JJ
cord-280878-1kt51viz	434	10	for	for	IN
cord-280878-1kt51viz	434	11	this	this	DT
cord-280878-1kt51viz	434	12	protein	protein	NN
cord-280878-1kt51viz	434	13	or	or	CC
cord-280878-1kt51viz	434	14	its	-PRON-	PRP$
cord-280878-1kt51viz	434	15	oligomers	oligomer	NNS
cord-280878-1kt51viz	434	16	.	.	.
cord-280878-1kt51viz	435	1	One	one	CD
cord-280878-1kt51viz	435	2	common	common	JJ
cord-280878-1kt51viz	435	3	,	,	,
cord-280878-1kt51viz	435	4	specific	specific	JJ
cord-280878-1kt51viz	435	5	effect	effect	NN
cord-280878-1kt51viz	435	6	of	of	IN
cord-280878-1kt51viz	435	7	viroporin	viroporin	NN
cord-280878-1kt51viz	435	8	channel	channel	NN
cord-280878-1kt51viz	435	9	activity	activity	NN
cord-280878-1kt51viz	435	10	may	may	MD
cord-280878-1kt51viz	435	11	be	be	VB
cord-280878-1kt51viz	435	12	associated	associate	VBN
cord-280878-1kt51viz	435	13	with	with	IN
cord-280878-1kt51viz	435	14	the	the	DT
cord-280878-1kt51viz	435	15	observed	observed	JJ
cord-280878-1kt51viz	435	16	ability	ability	NN
cord-280878-1kt51viz	435	17	of	of	IN
cord-280878-1kt51viz	435	18	viruses	virus	NNS
cord-280878-1kt51viz	435	19	to	to	TO
cord-280878-1kt51viz	435	20	activate	activate	VB
cord-280878-1kt51viz	435	21	the	the	DT
cord-280878-1kt51viz	435	22	host	host	NN
cord-280878-1kt51viz	435	23	inflammasome	inflammasome	NN
cord-280878-1kt51viz	435	24	,	,	,
cord-280878-1kt51viz	435	25	which	which	WDT
cord-280878-1kt51viz	435	26	activates	activate	VBZ
cord-280878-1kt51viz	435	27	caspase-1	caspase-1	NNP
cord-280878-1kt51viz	435	28	to	to	TO
cord-280878-1kt51viz	435	29	produce	produce	VB
cord-280878-1kt51viz	435	30	proinflammatory	proinflammatory	JJ
cord-280878-1kt51viz	435	31	cytokines	cytokine	NNS
cord-280878-1kt51viz	435	32	,	,	,
cord-280878-1kt51viz	435	33	eg	eg	XX
cord-280878-1kt51viz	435	34	,	,	,
cord-280878-1kt51viz	435	35	IL-1β	il-1β	WRB
cord-280878-1kt51viz	435	36	.	.	.
cord-280878-1kt51viz	436	1	These	these	DT
cord-280878-1kt51viz	436	2	effects	effect	NNS
cord-280878-1kt51viz	436	3	have	have	VBP
cord-280878-1kt51viz	436	4	been	be	VBN
cord-280878-1kt51viz	436	5	shown	show	VBN
cord-280878-1kt51viz	436	6	in	in	IN
cord-280878-1kt51viz	436	7	many	many	JJ
cord-280878-1kt51viz	436	8	cases	case	NNS
cord-280878-1kt51viz	436	9	to	to	TO
cord-280878-1kt51viz	436	10	be	be	VB
cord-280878-1kt51viz	436	11	caused	cause	VBN
cord-280878-1kt51viz	436	12	by	by	IN
cord-280878-1kt51viz	436	13	the	the	DT
cord-280878-1kt51viz	436	14	disruption	disruption	NN
cord-280878-1kt51viz	436	15	of	of	IN
cord-280878-1kt51viz	436	16	cellular	cellular	JJ
cord-280878-1kt51viz	436	17	ion	ion	NN
cord-280878-1kt51viz	436	18	homeostasis	homeostasis	NN
cord-280878-1kt51viz	436	19	by	by	IN
cord-280878-1kt51viz	436	20	allowing	allow	VBG
cord-280878-1kt51viz	436	21	ion	ion	NN
cord-280878-1kt51viz	436	22	leakage	leakage	NN
cord-280878-1kt51viz	436	23	from	from	IN
cord-280878-1kt51viz	436	24	intracellular	intracellular	JJ
cord-280878-1kt51viz	436	25	organelles	organelle	NNS
cord-280878-1kt51viz	436	26	into	into	IN
cord-280878-1kt51viz	436	27	the	the	DT
cord-280878-1kt51viz	436	28	cytosol	cytosol	NN
cord-280878-1kt51viz	436	29	,	,	,
cord-280878-1kt51viz	436	30	through	through	IN
cord-280878-1kt51viz	436	31	the	the	DT
cord-280878-1kt51viz	436	32	expression	expression	NN
cord-280878-1kt51viz	436	33	of	of	IN
cord-280878-1kt51viz	436	34	viroporins	viroporin	NNS
cord-280878-1kt51viz	436	35	[	[	-LRB-
cord-280878-1kt51viz	436	36	reviewed	review	VBN
cord-280878-1kt51viz	436	37	in	in	IN
cord-280878-1kt51viz	436	38	Guo	Guo	NNP
cord-280878-1kt51viz	436	39	,	,	,
cord-280878-1kt51viz	436	40	Jin	Jin	NNP
cord-280878-1kt51viz	436	41	,	,	,
cord-280878-1kt51viz	436	42	Zhi	Zhi	NNP
cord-280878-1kt51viz	436	43	,	,	,
cord-280878-1kt51viz	436	44	Yan	Yan	NNP
cord-280878-1kt51viz	436	45	,	,	,
cord-280878-1kt51viz	436	46	&	&	CC
cord-280878-1kt51viz	436	47	Sun	Sun	NNP
cord-280878-1kt51viz	436	48	,	,	,
cord-280878-1kt51viz	436	49	2015	2015	CD
cord-280878-1kt51viz	436	50	]	]	-RRB-
cord-280878-1kt51viz	436	51	.	.	.
cord-280878-1kt51viz	437	1	For	for	IN
cord-280878-1kt51viz	437	2	example	example	NN
cord-280878-1kt51viz	437	3	,	,	,
cord-280878-1kt51viz	437	4	the	the	DT
cord-280878-1kt51viz	437	5	IAV	IAV	NNP
cord-280878-1kt51viz	437	6	activates	activate	VBZ
cord-280878-1kt51viz	437	7	the	the	DT
cord-280878-1kt51viz	437	8	NLRP3	nlrp3	NN
cord-280878-1kt51viz	437	9	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	437	10	as	as	IN
cord-280878-1kt51viz	437	11	a	a	DT
cord-280878-1kt51viz	437	12	result	result	NN
cord-280878-1kt51viz	437	13	of	of	IN
cord-280878-1kt51viz	437	14	H	h	NN
cord-280878-1kt51viz	437	15	+	+	CC
cord-280878-1kt51viz	437	16	or	or	CC
cord-280878-1kt51viz	437	17	ion	ion	NN
cord-280878-1kt51viz	437	18	flux	flux	NN
cord-280878-1kt51viz	437	19	from	from	IN
cord-280878-1kt51viz	437	20	Golgi	Golgi	NNP
cord-280878-1kt51viz	437	21	mediated	mediate	VBN
cord-280878-1kt51viz	437	22	by	by	IN
cord-280878-1kt51viz	437	23	its	-PRON-	PRP$
cord-280878-1kt51viz	437	24	M2	M2	NNP
cord-280878-1kt51viz	437	25	ion	ion	NN
cord-280878-1kt51viz	437	26	channel	channel	NN
cord-280878-1kt51viz	437	27	(	(	-LRB-
cord-280878-1kt51viz	437	28	Ichinohe	Ichinohe	NNP
cord-280878-1kt51viz	437	29	,	,	,
cord-280878-1kt51viz	437	30	Pang	Pang	NNP
cord-280878-1kt51viz	437	31	,	,	,
cord-280878-1kt51viz	437	32	&	&	CC
cord-280878-1kt51viz	437	33	Iwasaki	Iwasaki	NNP
cord-280878-1kt51viz	437	34	,	,	,
cord-280878-1kt51viz	437	35	2010	2010	CD
cord-280878-1kt51viz	437	36	)	)	-RRB-
cord-280878-1kt51viz	437	37	.	.	.
cord-280878-1kt51viz	438	1	The	the	DT
cord-280878-1kt51viz	438	2	2B	2b	CD
cord-280878-1kt51viz	438	3	protein	protein	NN
cord-280878-1kt51viz	438	4	from	from	IN
cord-280878-1kt51viz	438	5	several	several	JJ
cord-280878-1kt51viz	438	6	picornaviruses	picornavirus	NNS
cord-280878-1kt51viz	438	7	,	,	,
cord-280878-1kt51viz	438	8	including	include	VBG
cord-280878-1kt51viz	438	9	the	the	DT
cord-280878-1kt51viz	438	10	encephalomyocarditis	encephalomyocarditis	NNP
cord-280878-1kt51viz	438	11	virus	virus	NN
cord-280878-1kt51viz	438	12	(	(	-LRB-
cord-280878-1kt51viz	438	13	EMCV	EMCV	NNP
cord-280878-1kt51viz	438	14	)	)	-RRB-
cord-280878-1kt51viz	438	15	,	,	,
cord-280878-1kt51viz	438	16	poliovirus	poliovirus	NN
cord-280878-1kt51viz	438	17	,	,	,
cord-280878-1kt51viz	438	18	enterovirus	enterovirus	NN
cord-280878-1kt51viz	438	19	71	71	CD
cord-280878-1kt51viz	438	20	,	,	,
cord-280878-1kt51viz	438	21	and	and	CC
cord-280878-1kt51viz	438	22	human	human	JJ
cord-280878-1kt51viz	438	23	rhinovirus	rhinovirus	NN
cord-280878-1kt51viz	438	24	(	(	-LRB-
cord-280878-1kt51viz	438	25	Triantafilou	Triantafilou	NNP
cord-280878-1kt51viz	438	26	,	,	,
cord-280878-1kt51viz	438	27	Kar	Kar	NNP
cord-280878-1kt51viz	438	28	,	,	,
cord-280878-1kt51viz	438	29	van	van	NNP
cord-280878-1kt51viz	438	30	Kuppeveld	Kuppeveld	NNP
cord-280878-1kt51viz	438	31	,	,	,
cord-280878-1kt51viz	438	32	&	&	CC
cord-280878-1kt51viz	438	33	Triantafilou	Triantafilou	NNP
cord-280878-1kt51viz	438	34	,	,	,
cord-280878-1kt51viz	438	35	2013	2013	CD
cord-280878-1kt51viz	438	36	)	)	-RRB-
cord-280878-1kt51viz	438	37	were	be	VBD
cord-280878-1kt51viz	438	38	shown	show	VBN
cord-280878-1kt51viz	438	39	to	to	TO
cord-280878-1kt51viz	438	40	induce	induce	VB
cord-280878-1kt51viz	438	41	NLRP3	nlrp3	XX
cord-280878-1kt51viz	438	42	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	438	43	relocalization	relocalization	NN
cord-280878-1kt51viz	438	44	and	and	CC
cord-280878-1kt51viz	438	45	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	438	46	activation	activation	NN
cord-280878-1kt51viz	438	47	in	in	IN
cord-280878-1kt51viz	438	48	an	an	DT
cord-280878-1kt51viz	438	49	intracellular	intracellular	JJ
cord-280878-1kt51viz	438	50	Ca	Ca	NNP
cord-280878-1kt51viz	438	51	2	2	CD
cord-280878-1kt51viz	438	52	+	+	SYM
cord-280878-1kt51viz	438	53	-mediated	-mediated	JJ
cord-280878-1kt51viz	438	54	manner	manner	NN
cord-280878-1kt51viz	438	55	(	(	-LRB-
cord-280878-1kt51viz	438	56	Ito	Ito	NNP
cord-280878-1kt51viz	438	57	,	,	,
cord-280878-1kt51viz	438	58	Yanagi	Yanagi	NNP
cord-280878-1kt51viz	438	59	,	,	,
cord-280878-1kt51viz	438	60	&	&	CC
cord-280878-1kt51viz	438	61	Ichinohe	Ichinohe	NNP
cord-280878-1kt51viz	438	62	,	,	,
cord-280878-1kt51viz	438	63	2012	2012	CD
cord-280878-1kt51viz	438	64	)	)	-RRB-
cord-280878-1kt51viz	438	65	.	.	.
cord-280878-1kt51viz	439	1	The	the	DT
cord-280878-1kt51viz	439	2	channel	channel	NN
cord-280878-1kt51viz	439	3	activity	activity	NN
cord-280878-1kt51viz	439	4	of	of	IN
cord-280878-1kt51viz	439	5	the	the	DT
cord-280878-1kt51viz	439	6	SARS	SARS	NNP
cord-280878-1kt51viz	439	7	-	-	HYPH
cord-280878-1kt51viz	439	8	CoV	CoV	NNP
cord-280878-1kt51viz	439	9	E	e	NN
cord-280878-1kt51viz	439	10	protein	protein	NN
cord-280878-1kt51viz	439	11	is	be	VBZ
cord-280878-1kt51viz	439	12	required	require	VBN
cord-280878-1kt51viz	439	13	for	for	IN
cord-280878-1kt51viz	439	14	the	the	DT
cord-280878-1kt51viz	439	15	processing	processing	NN
cord-280878-1kt51viz	439	16	of	of	IN
cord-280878-1kt51viz	439	17	IL-1β	IL-1β	NNP
cord-280878-1kt51viz	439	18	(	(	-LRB-
cord-280878-1kt51viz	439	19	Nieto-	Nieto-	NNP
cord-280878-1kt51viz	439	20	,	,	,
cord-280878-1kt51viz	439	21	which	which	WDT
cord-280878-1kt51viz	439	22	requires	require	VBZ
cord-280878-1kt51viz	439	23	caspase-1	caspase-1	NNP
cord-280878-1kt51viz	439	24	activation	activation	NN
cord-280878-1kt51viz	439	25	.	.	.
cord-280878-1kt51viz	440	1	Channel	channel	NN
cord-280878-1kt51viz	440	2	activity	activity	NN
cord-280878-1kt51viz	440	3	of	of	IN
cord-280878-1kt51viz	440	4	the	the	DT
cord-280878-1kt51viz	440	5	SH	SH	NNP
cord-280878-1kt51viz	440	6	protein	protein	NN
cord-280878-1kt51viz	440	7	may	may	MD
cord-280878-1kt51viz	440	8	also	also	RB
cord-280878-1kt51viz	440	9	result	result	VB
cord-280878-1kt51viz	440	10	directly	directly	RB
cord-280878-1kt51viz	440	11	or	or	CC
cord-280878-1kt51viz	440	12	indirectly	indirectly	RB
cord-280878-1kt51viz	440	13	in	in	IN
cord-280878-1kt51viz	440	14	activation	activation	NN
cord-280878-1kt51viz	440	15	of	of	IN
cord-280878-1kt51viz	440	16	the	the	DT
cord-280878-1kt51viz	440	17	NLRP3	NLRP3	NNP
cord-280878-1kt51viz	440	18	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	440	19	(	(	-LRB-
cord-280878-1kt51viz	440	20	Segovia	Segovia	NNP
cord-280878-1kt51viz	440	21	et	et	NNP
cord-280878-1kt51viz	440	22	al	al	NNP
cord-280878-1kt51viz	440	23	.	.	NNP
cord-280878-1kt51viz	440	24	,	,	,
cord-280878-1kt51viz	440	25	2012	2012	CD
cord-280878-1kt51viz	440	26	;	;	:
cord-280878-1kt51viz	440	27	Triantafilou	Triantafilou	NNP
cord-280878-1kt51viz	440	28	,	,	,
cord-280878-1kt51viz	440	29	Kar	Kar	NNP
cord-280878-1kt51viz	440	30	,	,	,
cord-280878-1kt51viz	440	31	Vakakis	Vakakis	NNP
cord-280878-1kt51viz	440	32	,	,	,
cord-280878-1kt51viz	440	33	Kotecha	Kotecha	NNP
cord-280878-1kt51viz	440	34	,	,	,
cord-280878-1kt51viz	440	35	&	&	CC
cord-280878-1kt51viz	440	36	Triantafilou	Triantafilou	NNP
cord-280878-1kt51viz	440	37	,	,	,
cord-280878-1kt51viz	440	38	2013	2013	CD
cord-280878-1kt51viz	440	39	)	)	-RRB-
cord-280878-1kt51viz	440	40	.	.	.
cord-280878-1kt51viz	441	1	In	in	IN
cord-280878-1kt51viz	441	2	these	these	DT
cord-280878-1kt51viz	441	3	cases	case	NNS
cord-280878-1kt51viz	441	4	,	,	,
cord-280878-1kt51viz	441	5	therefore	therefore	RB
cord-280878-1kt51viz	441	6	,	,	,
cord-280878-1kt51viz	441	7	development	development	NN
cord-280878-1kt51viz	441	8	of	of	IN
cord-280878-1kt51viz	441	9	channel	channel	NN
cord-280878-1kt51viz	441	10	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	441	11	should	should	MD
cord-280878-1kt51viz	441	12	improve	improve	VB
cord-280878-1kt51viz	441	13	the	the	DT
cord-280878-1kt51viz	441	14	pathological	pathological	JJ
cord-280878-1kt51viz	441	15	effects	effect	NNS
cord-280878-1kt51viz	441	16	of	of	IN
cord-280878-1kt51viz	441	17	host	host	NN
cord-280878-1kt51viz	441	18	inflammation	inflammation	NN
cord-280878-1kt51viz	441	19	caused	cause	VBN
cord-280878-1kt51viz	441	20	by	by	IN
cord-280878-1kt51viz	441	21	these	these	DT
cord-280878-1kt51viz	441	22	viruses	virus	NNS
cord-280878-1kt51viz	441	23	.	.	.
cord-280878-1kt51viz	442	1	Apart	apart	RB
cord-280878-1kt51viz	442	2	from	from	IN
cord-280878-1kt51viz	442	3	the	the	DT
cord-280878-1kt51viz	442	4	effects	effect	NNS
cord-280878-1kt51viz	442	5	of	of	IN
cord-280878-1kt51viz	442	6	their	-PRON-	PRP$
cord-280878-1kt51viz	442	7	channel	channel	NN
cord-280878-1kt51viz	442	8	activity	activity	NN
cord-280878-1kt51viz	442	9	,	,	,
cord-280878-1kt51viz	442	10	viroporins	viroporin	NNS
cord-280878-1kt51viz	442	11	are	be	VBP
cord-280878-1kt51viz	442	12	involved	involve	VBN
cord-280878-1kt51viz	442	13	in	in	IN
cord-280878-1kt51viz	442	14	many	many	JJ
cord-280878-1kt51viz	442	15	protein	protein	NN
cord-280878-1kt51viz	442	16	-	-	HYPH
cord-280878-1kt51viz	442	17	protein	protein	NN
cord-280878-1kt51viz	442	18	interactions	interaction	NNS
cord-280878-1kt51viz	442	19	(	(	-LRB-
cord-280878-1kt51viz	442	20	PPIs	ppi	NNS
cord-280878-1kt51viz	442	21	)	)	-RRB-
cord-280878-1kt51viz	442	22	that	that	WDT
cord-280878-1kt51viz	442	23	are	be	VBP
cord-280878-1kt51viz	442	24	susceptible	susceptible	JJ
cord-280878-1kt51viz	442	25	for	for	IN
cord-280878-1kt51viz	442	26	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	442	27	intervention	intervention	NN
cord-280878-1kt51viz	442	28	,	,	,
cord-280878-1kt51viz	442	29	and	and	CC
cord-280878-1kt51viz	442	30	may	may	MD
cord-280878-1kt51viz	442	31	be	be	VB
cord-280878-1kt51viz	442	32	increasingly	increasingly	RB
cord-280878-1kt51viz	442	33	important	important	JJ
cord-280878-1kt51viz	442	34	once	once	IN
cord-280878-1kt51viz	442	35	these	these	DT
cord-280878-1kt51viz	442	36	interactions	interaction	NNS
cord-280878-1kt51viz	442	37	are	be	VBP
cord-280878-1kt51viz	442	38	properly	properly	RB
cord-280878-1kt51viz	442	39	characterized	characterize	VBN
cord-280878-1kt51viz	442	40	[	[	-LRB-
cord-280878-1kt51viz	442	41	see	see	VB
cord-280878-1kt51viz	442	42	recent	recent	JJ
cord-280878-1kt51viz	442	43	reviews	review	NNS
cord-280878-1kt51viz	442	44	Fischer	Fischer	NNP
cord-280878-1kt51viz	442	45	,	,	,
cord-280878-1kt51viz	442	46	Li	Li	NNP
cord-280878-1kt51viz	442	47	,	,	,
cord-280878-1kt51viz	442	48	Mahato	Mahato	NNP
cord-280878-1kt51viz	442	49	,	,	,
cord-280878-1kt51viz	442	50	Wang	Wang	NNP
cord-280878-1kt51viz	442	51	,	,	,
cord-280878-1kt51viz	442	52	&	&	CC
cord-280878-1kt51viz	442	53	Chen	Chen	NNP
cord-280878-1kt51viz	442	54	,	,	,
cord-280878-1kt51viz	442	55	2014	2014	CD
cord-280878-1kt51viz	442	56	;	;	.
cord-280878-1kt51viz	443	1	Fischer	Fischer	NNP
cord-280878-1kt51viz	443	2	et	et	NNP
cord-280878-1kt51viz	443	3	al	al	NNP
cord-280878-1kt51viz	443	4	.	.	NNP
cord-280878-1kt51viz	443	5	,	,	,
cord-280878-1kt51viz	443	6	2012	2012	CD
cord-280878-1kt51viz	443	7	;	;	:
cord-280878-1kt51viz	443	8	Nieva	Nieva	NNP
cord-280878-1kt51viz	443	9	&	&	CC
cord-280878-1kt51viz	443	10	Carrasco	Carrasco	NNP
cord-280878-1kt51viz	443	11	,	,	,
cord-280878-1kt51viz	443	12	2015	2015	CD
cord-280878-1kt51viz	443	13	]	]	-RRB-
cord-280878-1kt51viz	443	14	.	.	.
cord-280878-1kt51viz	444	1	For	for	IN
cord-280878-1kt51viz	444	2	example	example	NN
cord-280878-1kt51viz	444	3	,	,	,
cord-280878-1kt51viz	444	4	the	the	DT
cord-280878-1kt51viz	444	5	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	444	6	regions	region	NNS
cord-280878-1kt51viz	444	7	of	of	IN
cord-280878-1kt51viz	444	8	AM2	AM2	NNP
cord-280878-1kt51viz	444	9	and	and	CC
cord-280878-1kt51viz	444	10	BM2	BM2	NNP
cord-280878-1kt51viz	444	11	are	be	VBP
cord-280878-1kt51viz	444	12	important	important	JJ
cord-280878-1kt51viz	444	13	for	for	IN
cord-280878-1kt51viz	444	14	proper	proper	JJ
cord-280878-1kt51viz	444	15	virus	virus	NN
cord-280878-1kt51viz	444	16	assembly	assembly	NN
cord-280878-1kt51viz	444	17	and	and	CC
cord-280878-1kt51viz	444	18	interaction	interaction	NN
cord-280878-1kt51viz	444	19	with	with	IN
cord-280878-1kt51viz	444	20	M1	M1	NNP
cord-280878-1kt51viz	444	21	(	(	-LRB-
cord-280878-1kt51viz	444	22	Chen	Chen	NNP
cord-280878-1kt51viz	444	23	,	,	,
cord-280878-1kt51viz	444	24	Leser	Leser	NNP
cord-280878-1kt51viz	444	25	,	,	,
cord-280878-1kt51viz	444	26	Jackson	Jackson	NNP
cord-280878-1kt51viz	444	27	,	,	,
cord-280878-1kt51viz	444	28	&	&	CC
cord-280878-1kt51viz	444	29	Lamb	Lamb	NNP
cord-280878-1kt51viz	444	30	,	,	,
cord-280878-1kt51viz	444	31	2008	2008	CD
cord-280878-1kt51viz	444	32	;	;	:
cord-280878-1kt51viz	444	33	Imai	Imai	NNP
cord-280878-1kt51viz	444	34	,	,	,
cord-280878-1kt51viz	444	35	Kawasaki	Kawasaki	NNP
cord-280878-1kt51viz	444	36	,	,	,
cord-280878-1kt51viz	444	37	&	&	CC
cord-280878-1kt51viz	444	38	Odagiri	Odagiri	NNP
cord-280878-1kt51viz	444	39	,	,	,
cord-280878-1kt51viz	444	40	2008	2008	CD
cord-280878-1kt51viz	444	41	;	;	:
cord-280878-1kt51viz	444	42	Imai	Imai	NNP
cord-280878-1kt51viz	444	43	,	,	,
cord-280878-1kt51viz	444	44	Watanabe	Watanabe	NNP
cord-280878-1kt51viz	444	45	,	,	,
cord-280878-1kt51viz	444	46	Ninomiya	Ninomiya	NNP
cord-280878-1kt51viz	444	47	,	,	,
cord-280878-1kt51viz	444	48	Obuchi	Obuchi	NNP
cord-280878-1kt51viz	444	49	,	,	,
cord-280878-1kt51viz	444	50	&	&	CC
cord-280878-1kt51viz	444	51	Odagiri	Odagiri	NNP
cord-280878-1kt51viz	444	52	,	,	,
cord-280878-1kt51viz	444	53	2004	2004	CD
cord-280878-1kt51viz	444	54	;	;	:
cord-280878-1kt51viz	444	55	McCown	McCown	NNP
cord-280878-1kt51viz	444	56	&	&	CC
cord-280878-1kt51viz	444	57	Pekosz	Pekosz	NNP
cord-280878-1kt51viz	444	58	,	,	,
cord-280878-1kt51viz	444	59	2006	2006	CD
cord-280878-1kt51viz	444	60	)	)	-RRB-
cord-280878-1kt51viz	444	61	,	,	,
cord-280878-1kt51viz	444	62	which	which	WDT
cord-280878-1kt51viz	444	63	can	can	MD
cord-280878-1kt51viz	444	64	be	be	VB
cord-280878-1kt51viz	444	65	proposed	propose	VBN
cord-280878-1kt51viz	444	66	as	as	IN
cord-280878-1kt51viz	444	67	an	an	DT
cord-280878-1kt51viz	444	68	attractive	attractive	JJ
cord-280878-1kt51viz	444	69	drug	drug	NN
cord-280878-1kt51viz	444	70	target	target	NN
cord-280878-1kt51viz	444	71	.	.	.
cord-280878-1kt51viz	445	1	Also	also	RB
cord-280878-1kt51viz	445	2	,	,	,
cord-280878-1kt51viz	445	3	the	the	DT
cord-280878-1kt51viz	445	4	HCV	HCV	NNP
cord-280878-1kt51viz	445	5	p7	p7	NN
cord-280878-1kt51viz	445	6	interacts	interact	VBZ
cord-280878-1kt51viz	445	7	with	with	IN
cord-280878-1kt51viz	445	8	other	other	JJ
cord-280878-1kt51viz	445	9	viral	viral	JJ
cord-280878-1kt51viz	445	10	structural	structural	JJ
cord-280878-1kt51viz	445	11	and	and	CC
cord-280878-1kt51viz	445	12	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	445	13	proteins	protein	NNS
cord-280878-1kt51viz	445	14	that	that	WDT
cord-280878-1kt51viz	445	15	are	be	VBP
cord-280878-1kt51viz	445	16	important	important	JJ
cord-280878-1kt51viz	445	17	to	to	TO
cord-280878-1kt51viz	445	18	promote	promote	VB
cord-280878-1kt51viz	445	19	virus	virus	NN
cord-280878-1kt51viz	445	20	assembly	assembly	NN
cord-280878-1kt51viz	445	21	and	and	CC
cord-280878-1kt51viz	445	22	release	release	NN
cord-280878-1kt51viz	445	23	(	(	-LRB-
cord-280878-1kt51viz	445	24	Gentzsch	Gentzsch	NNP
cord-280878-1kt51viz	445	25	et	et	NNP
cord-280878-1kt51viz	445	26	al	al	NNP
cord-280878-1kt51viz	445	27	.	.	NNP
cord-280878-1kt51viz	445	28	,	,	,
cord-280878-1kt51viz	445	29	2013	2013	CD
cord-280878-1kt51viz	445	30	;	;	:
cord-280878-1kt51viz	445	31	Haqshenas	Haqshenas	NNP
cord-280878-1kt51viz	445	32	,	,	,
cord-280878-1kt51viz	445	33	Dong	Dong	NNP
cord-280878-1kt51viz	445	34	,	,	,
cord-280878-1kt51viz	445	35	Ewart	Ewart	NNP
cord-280878-1kt51viz	445	36	,	,	,
cord-280878-1kt51viz	445	37	Bowden	Bowden	NNP
cord-280878-1kt51viz	445	38	,	,	,
cord-280878-1kt51viz	445	39	&	&	CC
cord-280878-1kt51viz	445	40	Gowans	Gowans	NNPS
cord-280878-1kt51viz	445	41	,	,	,
cord-280878-1kt51viz	445	42	2007	2007	CD
cord-280878-1kt51viz	445	43	;	;	:
cord-280878-1kt51viz	445	44	Pietschmann	Pietschmann	NNP
cord-280878-1kt51viz	445	45	et	et	NNP
cord-280878-1kt51viz	445	46	al	al	NNP
cord-280878-1kt51viz	445	47	.	.	NNP
cord-280878-1kt51viz	445	48	,	,	,
cord-280878-1kt51viz	445	49	2006	2006	CD
cord-280878-1kt51viz	445	50	;	;	:
cord-280878-1kt51viz	445	51	Sakai	Sakai	NNP
cord-280878-1kt51viz	445	52	et	et	NNP
cord-280878-1kt51viz	445	53	al	al	NNP
cord-280878-1kt51viz	445	54	.	.	NNP
cord-280878-1kt51viz	445	55	,	,	,
cord-280878-1kt51viz	445	56	2003	2003	CD
cord-280878-1kt51viz	445	57	;	;	:
cord-280878-1kt51viz	445	58	Yi	Yi	NNP
cord-280878-1kt51viz	445	59	,	,	,
cord-280878-1kt51viz	445	60	Ma	Ma	NNP
cord-280878-1kt51viz	445	61	,	,	,
cord-280878-1kt51viz	445	62	Yates	Yates	NNP
cord-280878-1kt51viz	445	63	,	,	,
cord-280878-1kt51viz	445	64	&	&	CC
cord-280878-1kt51viz	445	65	Lemon	Lemon	NNP
cord-280878-1kt51viz	445	66	,	,	,
cord-280878-1kt51viz	445	67	2007	2007	CD
cord-280878-1kt51viz	445	68	)	)	-RRB-
cord-280878-1kt51viz	445	69	,	,	,
cord-280878-1kt51viz	445	70	and	and	CC
cord-280878-1kt51viz	445	71	functions	function	NNS
cord-280878-1kt51viz	445	72	related	relate	VBN
cord-280878-1kt51viz	445	73	to	to	IN
cord-280878-1kt51viz	445	74	capsid	capsid	NN
cord-280878-1kt51viz	445	75	assembly	assembly	NN
cord-280878-1kt51viz	445	76	and	and	CC
cord-280878-1kt51viz	445	77	localization	localization	NN
cord-280878-1kt51viz	445	78	of	of	IN
cord-280878-1kt51viz	445	79	several	several	JJ
cord-280878-1kt51viz	445	80	viral	viral	JJ
cord-280878-1kt51viz	445	81	proteins	protein	NNS
cord-280878-1kt51viz	445	82	are	be	VBP
cord-280878-1kt51viz	445	83	not	not	RB
cord-280878-1kt51viz	445	84	affected	affect	VBN
cord-280878-1kt51viz	445	85	by	by	IN
cord-280878-1kt51viz	445	86	either	either	DT
cord-280878-1kt51viz	445	87	channel	channel	NN
cord-280878-1kt51viz	445	88	-	-	HYPH
cord-280878-1kt51viz	445	89	inactivating	inactivate	VBG
cord-280878-1kt51viz	445	90	mutations	mutation	NNS
cord-280878-1kt51viz	445	91	or	or	CC
cord-280878-1kt51viz	445	92	treatment	treatment	NN
cord-280878-1kt51viz	445	93	with	with	IN
cord-280878-1kt51viz	445	94	Rim	Rim	NNP
cord-280878-1kt51viz	445	95	(	(	-LRB-
cord-280878-1kt51viz	445	96	Tedbury	Tedbury	NNP
cord-280878-1kt51viz	445	97	et	et	NNP
cord-280878-1kt51viz	445	98	al	al	NNP
cord-280878-1kt51viz	445	99	.	.	NNP
cord-280878-1kt51viz	445	100	,	,	,
cord-280878-1kt51viz	445	101	2011	2011	CD
cord-280878-1kt51viz	445	102	;	;	:
cord-280878-1kt51viz	445	103	Wozniak	Wozniak	NNP
cord-280878-1kt51viz	445	104	et	et	NNP
cord-280878-1kt51viz	445	105	al	al	NNP
cord-280878-1kt51viz	445	106	.	.	NNP
cord-280878-1kt51viz	445	107	,	,	,
cord-280878-1kt51viz	445	108	2010	2010	CD
cord-280878-1kt51viz	445	109	)	)	-RRB-
cord-280878-1kt51viz	445	110	,	,	,
cord-280878-1kt51viz	445	111	eg	eg	XX
cord-280878-1kt51viz	445	112	,	,	,
cord-280878-1kt51viz	445	113	the	the	DT
cord-280878-1kt51viz	445	114	transfer	transfer	NN
cord-280878-1kt51viz	445	115	of	of	IN
cord-280878-1kt51viz	445	116	HCV	HCV	NNP
cord-280878-1kt51viz	445	117	core	core	NN
cord-280878-1kt51viz	445	118	protein	protein	NN
cord-280878-1kt51viz	445	119	from	from	IN
cord-280878-1kt51viz	445	120	lipid	lipid	NN
cord-280878-1kt51viz	445	121	droplets	droplet	NNS
cord-280878-1kt51viz	445	122	to	to	IN
cord-280878-1kt51viz	445	123	the	the	DT
cord-280878-1kt51viz	445	124	ER	ER	NNP
cord-280878-1kt51viz	445	125	depends	depend	VBZ
cord-280878-1kt51viz	445	126	on	on	IN
cord-280878-1kt51viz	445	127	the	the	DT
cord-280878-1kt51viz	445	128	interaction	interaction	NN
cord-280878-1kt51viz	445	129	between	between	IN
cord-280878-1kt51viz	445	130	p7	p7	NN
cord-280878-1kt51viz	445	131	and	and	CC
cord-280878-1kt51viz	445	132	NS2	NS2	NNP
cord-280878-1kt51viz	445	133	(	(	-LRB-
cord-280878-1kt51viz	445	134	Boson	Boson	NNP
cord-280878-1kt51viz	445	135	,	,	,
cord-280878-1kt51viz	445	136	Granio	Granio	NNP
cord-280878-1kt51viz	445	137	,	,	,
cord-280878-1kt51viz	445	138	Bartenschlager	Bartenschlager	NNP
cord-280878-1kt51viz	445	139	,	,	,
cord-280878-1kt51viz	445	140	&	&	CC
cord-280878-1kt51viz	445	141	Cosset	Cosset	NNP
cord-280878-1kt51viz	445	142	,	,	,
cord-280878-1kt51viz	445	143	2011	2011	CD
cord-280878-1kt51viz	445	144	)	)	-RRB-
cord-280878-1kt51viz	445	145	.	.	.
cord-280878-1kt51viz	446	1	Therefore	therefore	RB
cord-280878-1kt51viz	446	2	,	,	,
cord-280878-1kt51viz	446	3	the	the	DT
cord-280878-1kt51viz	446	4	disruption	disruption	NN
cord-280878-1kt51viz	446	5	of	of	IN
cord-280878-1kt51viz	446	6	such	such	JJ
cord-280878-1kt51viz	446	7	interactions	interaction	NNS
cord-280878-1kt51viz	446	8	would	would	MD
cord-280878-1kt51viz	446	9	require	require	VB
cord-280878-1kt51viz	446	10	the	the	DT
cord-280878-1kt51viz	446	11	action	action	NN
cord-280878-1kt51viz	446	12	of	of	IN
cord-280878-1kt51viz	446	13	PPI	PPI	NNP
cord-280878-1kt51viz	446	14	modulators	modulator	NNS
cord-280878-1kt51viz	446	15	rather	rather	RB
cord-280878-1kt51viz	446	16	than	than	IN
cord-280878-1kt51viz	446	17	channel	channel	NNP
cord-280878-1kt51viz	446	18	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	446	19	.	.	.
cord-280878-1kt51viz	447	1	The	the	DT
cord-280878-1kt51viz	447	2	interaction	interaction	NN
cord-280878-1kt51viz	447	3	partners	partner	NNS
cord-280878-1kt51viz	447	4	of	of	IN
cord-280878-1kt51viz	447	5	E	E	NNP
cord-280878-1kt51viz	447	6	and	and	CC
cord-280878-1kt51viz	447	7	SH	sh	NN
cord-280878-1kt51viz	447	8	proteins	protein	NNS
cord-280878-1kt51viz	447	9	have	have	VBP
cord-280878-1kt51viz	447	10	been	be	VBN
cord-280878-1kt51viz	447	11	reviewed	review	VBN
cord-280878-1kt51viz	447	12	recently	recently	RB
cord-280878-1kt51viz	447	13	(	(	-LRB-
cord-280878-1kt51viz	447	14	Torres	Torres	NNP
cord-280878-1kt51viz	447	15	,	,	,
cord-280878-1kt51viz	447	16	Surya	Surya	NNP
cord-280878-1kt51viz	447	17	,	,	,
cord-280878-1kt51viz	447	18	Li	Li	NNP
cord-280878-1kt51viz	447	19	,	,	,
cord-280878-1kt51viz	447	20	&	&	CC
cord-280878-1kt51viz	447	21	Liu	Liu	NNP
cord-280878-1kt51viz	447	22	,	,	,
cord-280878-1kt51viz	447	23	2015	2015	CD
cord-280878-1kt51viz	447	24	)	)	-RRB-
cord-280878-1kt51viz	447	25	.	.	.
cord-280878-1kt51viz	448	1	In	in	IN
cord-280878-1kt51viz	448	2	the	the	DT
cord-280878-1kt51viz	448	3	case	case	NN
cord-280878-1kt51viz	448	4	of	of	IN
cord-280878-1kt51viz	448	5	CoV	CoV	NNP
cord-280878-1kt51viz	448	6	E	E	NNP
cord-280878-1kt51viz	448	7	proteins	protein	NNS
cord-280878-1kt51viz	448	8	,	,	,
cord-280878-1kt51viz	448	9	the	the	DT
cord-280878-1kt51viz	448	10	interaction	interaction	NN
cord-280878-1kt51viz	448	11	with	with	IN
cord-280878-1kt51viz	448	12	M	M	NNP
cord-280878-1kt51viz	448	13	protein	protein	NN
cord-280878-1kt51viz	448	14	has	have	VBZ
cord-280878-1kt51viz	448	15	long	long	RB
cord-280878-1kt51viz	448	16	been	be	VBN
cord-280878-1kt51viz	448	17	reported	report	VBN
cord-280878-1kt51viz	448	18	to	to	TO
cord-280878-1kt51viz	448	19	contribute	contribute	VB
cord-280878-1kt51viz	448	20	to	to	IN
cord-280878-1kt51viz	448	21	M	M	NNP
cord-280878-1kt51viz	448	22	localization	localization	NN
cord-280878-1kt51viz	448	23	and	and	CC
cord-280878-1kt51viz	448	24	virion	virion	NN
cord-280878-1kt51viz	448	25	formation	formation	NN
cord-280878-1kt51viz	448	26	(	(	-LRB-
cord-280878-1kt51viz	448	27	Corse	Corse	NNP
cord-280878-1kt51viz	448	28	&	&	CC
cord-280878-1kt51viz	448	29	Machamer	Machamer	NNP
cord-280878-1kt51viz	448	30	,	,	,
cord-280878-1kt51viz	448	31	2003	2003	CD
cord-280878-1kt51viz	448	32	;	;	:
cord-280878-1kt51viz	448	33	Hogue	Hogue	NNP
cord-280878-1kt51viz	448	34	&	&	CC
cord-280878-1kt51viz	448	35	Machamer	Machamer	NNP
cord-280878-1kt51viz	448	36	,	,	,
cord-280878-1kt51viz	448	37	2008	2008	CD
cord-280878-1kt51viz	448	38	;	;	.
cord-280878-1kt51viz	449	1	Ilk	Ilk	NNP
cord-280878-1kt51viz	449	2	,	,	,
cord-280878-1kt51viz	449	3	Egelseer	Egelseer	NNP
cord-280878-1kt51viz	449	4	,	,	,
cord-280878-1kt51viz	449	5	&	&	CC
cord-280878-1kt51viz	449	6	Sleytr	Sleytr	NNP
cord-280878-1kt51viz	449	7	,	,	,
cord-280878-1kt51viz	449	8	2011	2011	CD
cord-280878-1kt51viz	449	9	;	;	:
cord-280878-1kt51viz	449	10	Lim	Lim	NNP
cord-280878-1kt51viz	449	11	&	&	CC
cord-280878-1kt51viz	449	12	Liu	Liu	NNP
cord-280878-1kt51viz	449	13	,	,	,
cord-280878-1kt51viz	449	14	2001	2001	CD
cord-280878-1kt51viz	449	15	;	;	:
cord-280878-1kt51viz	449	16	Siu	Siu	NNP
cord-280878-1kt51viz	449	17	et	et	NNP
cord-280878-1kt51viz	449	18	al	al	NNP
cord-280878-1kt51viz	449	19	.	.	NNP
cord-280878-1kt51viz	449	20	,	,	,
cord-280878-1kt51viz	449	21	2008	2008	CD
cord-280878-1kt51viz	449	22	;	;	:
cord-280878-1kt51viz	449	23	Vennema	Vennema	NNP
cord-280878-1kt51viz	449	24	et	et	FW
cord-280878-1kt51viz	449	25	al	al	NNP
cord-280878-1kt51viz	449	26	.	.	NNP
cord-280878-1kt51viz	449	27	,	,	,
cord-280878-1kt51viz	449	28	1996	1996	CD
cord-280878-1kt51viz	449	29	)	)	-RRB-
cord-280878-1kt51viz	449	30	.	.	.
cord-280878-1kt51viz	450	1	Recent	recent	JJ
cord-280878-1kt51viz	450	2	reports	report	NNS
cord-280878-1kt51viz	450	3	have	have	VBP
cord-280878-1kt51viz	450	4	highlighted	highlight	VBN
cord-280878-1kt51viz	450	5	interactions	interaction	NNS
cord-280878-1kt51viz	450	6	with	with	IN
cord-280878-1kt51viz	450	7	Protein	Protein	NNP
cord-280878-1kt51viz	450	8	Associated	Associated	NNP
cord-280878-1kt51viz	450	9	with	with	IN
cord-280878-1kt51viz	450	10	Lin	Lin	NNP
cord-280878-1kt51viz	450	11	Seven	Seven	NNP
cord-280878-1kt51viz	450	12	1	1	CD
cord-280878-1kt51viz	451	1	(	(	-LRB-
cord-280878-1kt51viz	451	2	PALS1	PALS1	NNP
cord-280878-1kt51viz	451	3	)	)	-RRB-
cord-280878-1kt51viz	452	1	(	(	-LRB-
cord-280878-1kt51viz	452	2	Teoh	Teoh	NNP
cord-280878-1kt51viz	452	3	et	et	NNP
cord-280878-1kt51viz	452	4	al	al	NNP
cord-280878-1kt51viz	452	5	.	.	NNP
cord-280878-1kt51viz	452	6	,	,	,
cord-280878-1kt51viz	452	7	2010	2010	CD
cord-280878-1kt51viz	452	8	)	)	-RRB-
cord-280878-1kt51viz	452	9	and	and	CC
cord-280878-1kt51viz	452	10	syntenin	syntenin	VBP
cord-280878-1kt51viz	452	11	through	through	IN
cord-280878-1kt51viz	452	12	PDZ	PDZ	NNP
cord-280878-1kt51viz	452	13	domains	domain	NNS
cord-280878-1kt51viz	452	14	of	of	IN
cord-280878-1kt51viz	452	15	E	e	NN
cord-280878-1kt51viz	452	16	proteins	protein	NNS
cord-280878-1kt51viz	452	17	,	,	,
cord-280878-1kt51viz	452	18	which	which	WDT
cord-280878-1kt51viz	452	19	are	be	VBP
cord-280878-1kt51viz	452	20	consistent	consistent	JJ
cord-280878-1kt51viz	452	21	with	with	IN
cord-280878-1kt51viz	452	22	alterations	alteration	NNS
cord-280878-1kt51viz	452	23	of	of	IN
cord-280878-1kt51viz	452	24	lung	lung	NN
cord-280878-1kt51viz	452	25	epithelia	epithelium	NNS
cord-280878-1kt51viz	452	26	integrity	integrity	NN
cord-280878-1kt51viz	452	27	and	and	CC
cord-280878-1kt51viz	452	28	inflammation	inflammation	NN
cord-280878-1kt51viz	452	29	observed	observe	VBN
cord-280878-1kt51viz	452	30	during	during	IN
cord-280878-1kt51viz	452	31	CoV	cov	NN
cord-280878-1kt51viz	452	32	infection	infection	NN
cord-280878-1kt51viz	452	33	.	.	.
cord-280878-1kt51viz	453	1	Disruption	disruption	NN
cord-280878-1kt51viz	453	2	of	of	IN
cord-280878-1kt51viz	453	3	these	these	DT
cord-280878-1kt51viz	453	4	pathways	pathway	NNS
cord-280878-1kt51viz	453	5	may	may	MD
cord-280878-1kt51viz	453	6	have	have	VB
cord-280878-1kt51viz	453	7	clear	clear	JJ
cord-280878-1kt51viz	453	8	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	453	9	implications	implication	NNS
cord-280878-1kt51viz	453	10	,	,	,
cord-280878-1kt51viz	453	11	since	since	IN
cord-280878-1kt51viz	453	12	in	in	IN
cord-280878-1kt51viz	453	13	SARS	SARS	NNP
cord-280878-1kt51viz	453	14	-	-	HYPH
cord-280878-1kt51viz	453	15	CoV	CoV	NNP
cord-280878-1kt51viz	453	16	-	-	HYPH
cord-280878-1kt51viz	453	17	infected	infect	VBN
cord-280878-1kt51viz	453	18	patients	patient	NNS
cord-280878-1kt51viz	453	19	it	-PRON-	PRP
cord-280878-1kt51viz	453	20	is	be	VBZ
cord-280878-1kt51viz	453	21	an	an	DT
cord-280878-1kt51viz	453	22	exacerbated	exacerbate	VBN
cord-280878-1kt51viz	453	23	inflammatory	inflammatory	JJ
cord-280878-1kt51viz	453	24	response	response	NN
cord-280878-1kt51viz	453	25	that	that	WDT
cord-280878-1kt51viz	453	26	leads	lead	VBZ
cord-280878-1kt51viz	453	27	to	to	IN
cord-280878-1kt51viz	453	28	epithelial	epithelial	JJ
cord-280878-1kt51viz	453	29	and	and	CC
cord-280878-1kt51viz	453	30	endothelial	endothelial	JJ
cord-280878-1kt51viz	453	31	damage	damage	NN
cord-280878-1kt51viz	453	32	,	,	,
cord-280878-1kt51viz	453	33	edema	edema	NN
cord-280878-1kt51viz	453	34	,	,	,
cord-280878-1kt51viz	453	35	and	and	CC
cord-280878-1kt51viz	453	36	acute	acute	JJ
cord-280878-1kt51viz	453	37	respiratory	respiratory	JJ
cord-280878-1kt51viz	453	38	distress	distress	NN
cord-280878-1kt51viz	453	39	syndrome	syndrome	NN
cord-280878-1kt51viz	453	40	(	(	-LRB-
cord-280878-1kt51viz	453	41	Smits	Smits	NNP
cord-280878-1kt51viz	453	42	et	et	NNP
cord-280878-1kt51viz	453	43	al	al	NNP
cord-280878-1kt51viz	453	44	.	.	NNP
cord-280878-1kt51viz	453	45	,	,	,
cord-280878-1kt51viz	453	46	2010	2010	CD
cord-280878-1kt51viz	453	47	)	)	-RRB-
cord-280878-1kt51viz	453	48	.	.	.
cord-280878-1kt51viz	454	1	Noticeably	noticeably	RB
cord-280878-1kt51viz	454	2	,	,	,
cord-280878-1kt51viz	454	3	several	several	JJ
cord-280878-1kt51viz	454	4	other	other	JJ
cord-280878-1kt51viz	454	5	viruses	virus	NNS
cord-280878-1kt51viz	454	6	,	,	,
cord-280878-1kt51viz	454	7	eg	eg	IN
cord-280878-1kt51viz	454	8	,	,	,
cord-280878-1kt51viz	454	9	human	human	JJ
cord-280878-1kt51viz	454	10	papillomavirus	papillomavirus	NN
cord-280878-1kt51viz	454	11	and	and	CC
cord-280878-1kt51viz	454	12	influenza	influenza	NN
cord-280878-1kt51viz	454	13	A	a	NN
cord-280878-1kt51viz	454	14	,	,	,
cord-280878-1kt51viz	454	15	have	have	VBP
cord-280878-1kt51viz	454	16	been	be	VBN
cord-280878-1kt51viz	454	17	found	find	VBN
cord-280878-1kt51viz	454	18	to	to	TO
cord-280878-1kt51viz	454	19	enhance	enhance	VB
cord-280878-1kt51viz	454	20	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	454	21	through	through	IN
cord-280878-1kt51viz	454	22	proteins	protein	NNS
cord-280878-1kt51viz	454	23	containing	contain	VBG
cord-280878-1kt51viz	454	24	PDZ	PDZ	NNP
cord-280878-1kt51viz	454	25	binding	bind	VBG
cord-280878-1kt51viz	454	26	motifs	motif	NNS
cord-280878-1kt51viz	454	27	(	(	-LRB-
cord-280878-1kt51viz	454	28	reviewed	review	VBN
cord-280878-1kt51viz	454	29	in	in	IN
cord-280878-1kt51viz	454	30	Javier	Javier	NNP
cord-280878-1kt51viz	454	31	&	&	CC
cord-280878-1kt51viz	454	32	Rice	Rice	NNP
cord-280878-1kt51viz	454	33	,	,	,
cord-280878-1kt51viz	454	34	2011	2011	CD
cord-280878-1kt51viz	454	35	)	)	-RRB-
cord-280878-1kt51viz	454	36	,	,	,
cord-280878-1kt51viz	454	37	which	which	WDT
cord-280878-1kt51viz	454	38	suggests	suggest	VBZ
cord-280878-1kt51viz	454	39	that	that	IN
cord-280878-1kt51viz	454	40	this	this	DT
cord-280878-1kt51viz	454	41	is	be	VBZ
cord-280878-1kt51viz	454	42	a	a	DT
cord-280878-1kt51viz	454	43	particular	particular	JJ
cord-280878-1kt51viz	454	44	case	case	NN
cord-280878-1kt51viz	454	45	of	of	IN
cord-280878-1kt51viz	454	46	a	a	DT
cord-280878-1kt51viz	454	47	widely	widely	RB
cord-280878-1kt51viz	454	48	used	use	VBN
cord-280878-1kt51viz	454	49	viral	viral	JJ
cord-280878-1kt51viz	454	50	strategy	strategy	NN
cord-280878-1kt51viz	454	51	.	.	.
cord-280878-1kt51viz	455	1	Vpu	Vpu	NNP
cord-280878-1kt51viz	455	2	is	be	VBZ
cord-280878-1kt51viz	455	3	known	know	VBN
cord-280878-1kt51viz	455	4	for	for	IN
cord-280878-1kt51viz	455	5	its	-PRON-	PRP$
cord-280878-1kt51viz	455	6	ability	ability	NN
cord-280878-1kt51viz	455	7	to	to	TO
cord-280878-1kt51viz	455	8	degrade	degrade	VB
cord-280878-1kt51viz	455	9	the	the	DT
cord-280878-1kt51viz	455	10	HIV	HIV	NNP
cord-280878-1kt51viz	455	11	-	-	HYPH
cord-280878-1kt51viz	455	12	receptor	receptor	NN
cord-280878-1kt51viz	455	13	CD4	CD4	NNP
cord-280878-1kt51viz	455	14	(	(	-LRB-
cord-280878-1kt51viz	455	15	Bour	Bour	NNP
cord-280878-1kt51viz	455	16	&	&	CC
cord-280878-1kt51viz	455	17	Strebel	Strebel	NNP
cord-280878-1kt51viz	455	18	,	,	,
cord-280878-1kt51viz	455	19	2003	2003	CD
cord-280878-1kt51viz	455	20	)	)	-RRB-
cord-280878-1kt51viz	455	21	,	,	,
cord-280878-1kt51viz	455	22	which	which	WDT
cord-280878-1kt51viz	455	23	requires	require	VBZ
cord-280878-1kt51viz	455	24	interaction	interaction	NN
cord-280878-1kt51viz	455	25	between	between	IN
cord-280878-1kt51viz	455	26	Vpu	Vpu	NNP
cord-280878-1kt51viz	455	27	and	and	CC
cord-280878-1kt51viz	455	28	CD4	CD4	NNP
cord-280878-1kt51viz	455	29	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	455	30	domains	domain	NNS
cord-280878-1kt51viz	455	31	(	(	-LRB-
cord-280878-1kt51viz	455	32	McNatt	McNatt	NNP
cord-280878-1kt51viz	455	33	,	,	,
cord-280878-1kt51viz	455	34	Zang	Zang	NNP
cord-280878-1kt51viz	455	35	,	,	,
cord-280878-1kt51viz	455	36	&	&	CC
cord-280878-1kt51viz	455	37	Bieniasz	Bieniasz	NNP
cord-280878-1kt51viz	455	38	,	,	,
cord-280878-1kt51viz	455	39	2013	2013	CD
cord-280878-1kt51viz	455	40	;	;	:
cord-280878-1kt51viz	455	41	Singh	Singh	NNP
cord-280878-1kt51viz	455	42	et	et	NNP
cord-280878-1kt51viz	455	43	al	al	NNP
cord-280878-1kt51viz	455	44	.	.	NNP
cord-280878-1kt51viz	455	45	,	,	,
cord-280878-1kt51viz	455	46	2012	2012	CD
cord-280878-1kt51viz	455	47	)	)	-RRB-
cord-280878-1kt51viz	455	48	and	and	CC
cord-280878-1kt51viz	455	49	probably	probably	RB
cord-280878-1kt51viz	455	50	TM	TM	NNP
cord-280878-1kt51viz	455	51	domains	domain	NNS
cord-280878-1kt51viz	456	1	(	(	-LRB-
cord-280878-1kt51viz	456	2	Do	do	VB
cord-280878-1kt51viz	456	3	et	et	FW
cord-280878-1kt51viz	456	4	al	al	NNP
cord-280878-1kt51viz	456	5	.	.	NNP
cord-280878-1kt51viz	456	6	,	,	,
cord-280878-1kt51viz	456	7	2013	2013	CD
cord-280878-1kt51viz	456	8	;	;	:
cord-280878-1kt51viz	457	1	Magadán	Magadán	NNP
cord-280878-1kt51viz	457	2	&	&	CC
cord-280878-1kt51viz	457	3	Bonifacino	Bonifacino	NNP
cord-280878-1kt51viz	457	4	,	,	,
cord-280878-1kt51viz	457	5	2012	2012	CD
cord-280878-1kt51viz	457	6	)	)	-RRB-
cord-280878-1kt51viz	457	7	of	of	IN
cord-280878-1kt51viz	457	8	the	the	DT
cord-280878-1kt51viz	457	9	two	two	CD
cord-280878-1kt51viz	457	10	proteins	protein	NNS
cord-280878-1kt51viz	457	11	.	.	.
cord-280878-1kt51viz	458	1	This	this	DT
cord-280878-1kt51viz	458	2	may	may	MD
cord-280878-1kt51viz	458	3	not	not	RB
cord-280878-1kt51viz	458	4	even	even	RB
cord-280878-1kt51viz	458	5	require	require	VB
cord-280878-1kt51viz	458	6	formation	formation	NN
cord-280878-1kt51viz	458	7	of	of	IN
cord-280878-1kt51viz	458	8	oligomers	oligomer	NNS
cord-280878-1kt51viz	458	9	,	,	,
cord-280878-1kt51viz	458	10	and	and	CC
cord-280878-1kt51viz	458	11	even	even	RB
cord-280878-1kt51viz	458	12	less	less	JJR
cord-280878-1kt51viz	458	13	channel	channel	NN
cord-280878-1kt51viz	458	14	activity	activity	NN
cord-280878-1kt51viz	458	15	.	.	.
cord-280878-1kt51viz	459	1	Vpu	Vpu	NNP
cord-280878-1kt51viz	459	2	also	also	RB
cord-280878-1kt51viz	459	3	affects	affect	VBZ
cord-280878-1kt51viz	459	4	virus	virus	NN
cord-280878-1kt51viz	459	5	release	release	NN
cord-280878-1kt51viz	459	6	via	via	IN
cord-280878-1kt51viz	459	7	interaction	interaction	NN
cord-280878-1kt51viz	459	8	with	with	IN
cord-280878-1kt51viz	459	9	interferon	interferon	NN
cord-280878-1kt51viz	459	10	-	-	HYPH
cord-280878-1kt51viz	459	11	induced	induce	VBN
cord-280878-1kt51viz	459	12	protein	protein	NN
cord-280878-1kt51viz	459	13	tetherin	tetherin	NN
cord-280878-1kt51viz	459	14	(	(	-LRB-
cord-280878-1kt51viz	459	15	BST-2	BST-2	NNP
cord-280878-1kt51viz	459	16	)	)	-RRB-
cord-280878-1kt51viz	460	1	(	(	-LRB-
cord-280878-1kt51viz	460	2	Miyagi	Miyagi	NNP
cord-280878-1kt51viz	460	3	,	,	,
cord-280878-1kt51viz	460	4	Andrew	Andrew	NNP
cord-280878-1kt51viz	460	5	,	,	,
cord-280878-1kt51viz	460	6	Kao	Kao	NNP
cord-280878-1kt51viz	460	7	,	,	,
cord-280878-1kt51viz	460	8	&	&	CC
cord-280878-1kt51viz	460	9	Strebe	Strebe	NNP
cord-280878-1kt51viz	460	10	,	,	,
cord-280878-1kt51viz	460	11	2009	2009	CD
cord-280878-1kt51viz	460	12	;	;	:
cord-280878-1kt51viz	460	13	Neil	Neil	NNP
cord-280878-1kt51viz	460	14	,	,	,
cord-280878-1kt51viz	460	15	Zang	Zang	NNP
cord-280878-1kt51viz	460	16	,	,	,
cord-280878-1kt51viz	460	17	&	&	CC
cord-280878-1kt51viz	460	18	Bieniasz	Bieniasz	NNP
cord-280878-1kt51viz	460	19	,	,	,
cord-280878-1kt51viz	460	20	2008	2008	CD
cord-280878-1kt51viz	460	21	;	;	:
cord-280878-1kt51viz	460	22	Skasko	Skasko	NNP
cord-280878-1kt51viz	460	23	et	et	NNP
cord-280878-1kt51viz	460	24	al	al	NNP
cord-280878-1kt51viz	460	25	.	.	NNP
cord-280878-1kt51viz	460	26	,	,	,
cord-280878-1kt51viz	460	27	2012	2012	CD
cord-280878-1kt51viz	460	28	;	;	:
cord-280878-1kt51viz	460	29	Van	Van	NNP
cord-280878-1kt51viz	460	30	Damme	Damme	NNP
cord-280878-1kt51viz	460	31	et	et	NNP
cord-280878-1kt51viz	460	32	al	al	NNP
cord-280878-1kt51viz	460	33	.	.	NNP
cord-280878-1kt51viz	460	34	,	,	,
cord-280878-1kt51viz	460	35	2008	2008	CD
cord-280878-1kt51viz	460	36	)	)	-RRB-
cord-280878-1kt51viz	460	37	,	,	,
cord-280878-1kt51viz	460	38	an	an	DT
cord-280878-1kt51viz	460	39	interferon	interferon	NN
cord-280878-1kt51viz	460	40	-	-	HYPH
cord-280878-1kt51viz	460	41	induced	induce	VBN
cord-280878-1kt51viz	460	42	host	host	NN
cord-280878-1kt51viz	460	43	protein	protein	NN
cord-280878-1kt51viz	460	44	that	that	WDT
cord-280878-1kt51viz	460	45	inhibits	inhibit	VBZ
cord-280878-1kt51viz	460	46	the	the	DT
cord-280878-1kt51viz	460	47	release	release	NN
cord-280878-1kt51viz	460	48	of	of	IN
cord-280878-1kt51viz	460	49	many	many	JJ
cord-280878-1kt51viz	460	50	enveloped	envelop	VBN
cord-280878-1kt51viz	460	51	viruses	virus	NNS
cord-280878-1kt51viz	460	52	by	by	IN
cord-280878-1kt51viz	460	53	tethering	tether	VBG
cord-280878-1kt51viz	460	54	virions	virion	NNS
cord-280878-1kt51viz	460	55	to	to	IN
cord-280878-1kt51viz	460	56	the	the	DT
cord-280878-1kt51viz	460	57	cell	cell	NN
cord-280878-1kt51viz	460	58	surface	surface	NN
cord-280878-1kt51viz	460	59	[	[	-LRB-
cord-280878-1kt51viz	460	60	reviewed	review	VBN
cord-280878-1kt51viz	460	61	in	in	IN
cord-280878-1kt51viz	460	62	Strebel	Strebel	NNP
cord-280878-1kt51viz	460	63	,	,	,
cord-280878-1kt51viz	460	64	2014	2014	CD
cord-280878-1kt51viz	460	65	]	]	-RRB-
cord-280878-1kt51viz	460	66	.	.	.
cord-280878-1kt51viz	461	1	In	in	IN
cord-280878-1kt51viz	461	2	another	another	DT
cord-280878-1kt51viz	461	3	case	case	NN
cord-280878-1kt51viz	461	4	,	,	,
cord-280878-1kt51viz	461	5	the	the	DT
cord-280878-1kt51viz	461	6	interaction	interaction	NN
cord-280878-1kt51viz	461	7	between	between	IN
cord-280878-1kt51viz	461	8	RSV	RSV	NNP
cord-280878-1kt51viz	461	9	SH	SH	NNP
cord-280878-1kt51viz	461	10	and	and	CC
cord-280878-1kt51viz	461	11	G	g	NN
cord-280878-1kt51viz	461	12	proteins	protein	NNS
cord-280878-1kt51viz	461	13	has	have	VBZ
cord-280878-1kt51viz	461	14	been	be	VBN
cord-280878-1kt51viz	461	15	reported	report	VBN
cord-280878-1kt51viz	461	16	previously	previously	RB
cord-280878-1kt51viz	461	17	in	in	IN
cord-280878-1kt51viz	461	18	infected	infected	JJ
cord-280878-1kt51viz	461	19	cells	cell	NNS
cord-280878-1kt51viz	461	20	(	(	-LRB-
cord-280878-1kt51viz	461	21	Low	Low	NNP
cord-280878-1kt51viz	461	22	,	,	,
cord-280878-1kt51viz	461	23	Tan	Tan	NNP
cord-280878-1kt51viz	461	24	,	,	,
cord-280878-1kt51viz	461	25	Ng	Ng	NNP
cord-280878-1kt51viz	461	26	,	,	,
cord-280878-1kt51viz	461	27	Tan	Tan	NNP
cord-280878-1kt51viz	461	28	,	,	,
cord-280878-1kt51viz	461	29	&	&	CC
cord-280878-1kt51viz	461	30	Sugrue	Sugrue	NNP
cord-280878-1kt51viz	461	31	,	,	,
cord-280878-1kt51viz	461	32	2008	2008	CD
cord-280878-1kt51viz	461	33	;	;	:
cord-280878-1kt51viz	461	34	Rixon	Rixon	NNP
cord-280878-1kt51viz	461	35	,	,	,
cord-280878-1kt51viz	461	36	Brown	Brown	NNP
cord-280878-1kt51viz	461	37	,	,	,
cord-280878-1kt51viz	461	38	Murray	Murray	NNP
cord-280878-1kt51viz	461	39	,	,	,
cord-280878-1kt51viz	461	40	&	&	CC
cord-280878-1kt51viz	461	41	Sugrue	Sugrue	NNP
cord-280878-1kt51viz	461	42	,	,	,
cord-280878-1kt51viz	461	43	2005	2005	CD
cord-280878-1kt51viz	461	44	)	)	-RRB-
cord-280878-1kt51viz	461	45	,	,	,
cord-280878-1kt51viz	461	46	although	although	IN
cord-280878-1kt51viz	461	47	the	the	DT
cord-280878-1kt51viz	461	48	significance	significance	NN
cord-280878-1kt51viz	461	49	is	be	VBZ
cord-280878-1kt51viz	461	50	not	not	RB
cord-280878-1kt51viz	461	51	clear	clear	JJ
cord-280878-1kt51viz	461	52	yet	yet	RB
cord-280878-1kt51viz	461	53	.	.	.
cord-280878-1kt51viz	462	1	The	the	DT
cord-280878-1kt51viz	462	2	B	b	NN
cord-280878-1kt51viz	462	3	-	-	HYPH
cord-280878-1kt51viz	462	4	cell	cell	NN
cord-280878-1kt51viz	462	5	receptor	receptor	NN
cord-280878-1kt51viz	462	6	-	-	HYPH
cord-280878-1kt51viz	462	7	associated	associate	VBN
cord-280878-1kt51viz	462	8	protein	protein	NN
cord-280878-1kt51viz	462	9	31	31	CD
cord-280878-1kt51viz	462	10	(	(	-LRB-
cord-280878-1kt51viz	462	11	BAP31	BAP31	NNP
cord-280878-1kt51viz	462	12	)	)	-RRB-
cord-280878-1kt51viz	462	13	has	have	VBZ
cord-280878-1kt51viz	462	14	been	be	VBN
cord-280878-1kt51viz	462	15	recently	recently	RB
cord-280878-1kt51viz	462	16	reported	report	VBN
cord-280878-1kt51viz	462	17	to	to	TO
cord-280878-1kt51viz	462	18	interact	interact	VB
cord-280878-1kt51viz	462	19	with	with	IN
cord-280878-1kt51viz	462	20	the	the	DT
cord-280878-1kt51viz	462	21	SH	SH	NNP
cord-280878-1kt51viz	462	22	protein	protein	NN
cord-280878-1kt51viz	462	23	.	.	.
cord-280878-1kt51viz	463	1	Although	although	IN
cord-280878-1kt51viz	463	2	this	this	DT
cord-280878-1kt51viz	463	3	interaction	interaction	NN
cord-280878-1kt51viz	463	4	has	have	VBZ
cord-280878-1kt51viz	463	5	not	not	RB
cord-280878-1kt51viz	463	6	been	be	VBN
cord-280878-1kt51viz	463	7	reported	report	VBN
cord-280878-1kt51viz	463	8	in	in	IN
cord-280878-1kt51viz	463	9	infected	infected	JJ
cord-280878-1kt51viz	463	10	cells	cell	NNS
cord-280878-1kt51viz	463	11	,	,	,
cord-280878-1kt51viz	463	12	it	-PRON-	PRP
cord-280878-1kt51viz	463	13	could	could	MD
cord-280878-1kt51viz	463	14	prevent	prevent	VB
cord-280878-1kt51viz	463	15	the	the	DT
cord-280878-1kt51viz	463	16	cleavage	cleavage	NN
cord-280878-1kt51viz	463	17	of	of	IN
cord-280878-1kt51viz	463	18	BAP31	BAP31	NNP
cord-280878-1kt51viz	463	19	and	and	CC
cord-280878-1kt51viz	463	20	the	the	DT
cord-280878-1kt51viz	463	21	formation	formation	NN
cord-280878-1kt51viz	463	22	of	of	IN
cord-280878-1kt51viz	463	23	proapoptotic	proapoptotic	JJ
cord-280878-1kt51viz	463	24	fragment	fragment	NN
cord-280878-1kt51viz	463	25	p20	p20	NN
cord-280878-1kt51viz	463	26	,	,	,
cord-280878-1kt51viz	463	27	thus	thus	RB
cord-280878-1kt51viz	463	28	delaying	delay	VBG
cord-280878-1kt51viz	463	29	apoptosis	apoptosis	NN
cord-280878-1kt51viz	463	30	of	of	IN
cord-280878-1kt51viz	463	31	infected	infected	JJ
cord-280878-1kt51viz	463	32	cells	cell	NNS
cord-280878-1kt51viz	463	33	.	.	.
cord-280878-1kt51viz	464	1	Interaction	interaction	NN
cord-280878-1kt51viz	464	2	with	with	IN
cord-280878-1kt51viz	464	3	BAP31	BAP31	NNP
cord-280878-1kt51viz	464	4	was	be	VBD
cord-280878-1kt51viz	464	5	also	also	RB
cord-280878-1kt51viz	464	6	observed	observe	VBN
cord-280878-1kt51viz	464	7	in	in	IN
cord-280878-1kt51viz	464	8	the	the	DT
cord-280878-1kt51viz	464	9	E5	E5	NNP
cord-280878-1kt51viz	464	10	viroporin	viroporin	NN
cord-280878-1kt51viz	464	11	from	from	IN
cord-280878-1kt51viz	464	12	the	the	DT
cord-280878-1kt51viz	464	13	high	high	JJ
cord-280878-1kt51viz	464	14	-	-	HYPH
cord-280878-1kt51viz	464	15	risk	risk	NN
cord-280878-1kt51viz	464	16	human	human	JJ
cord-280878-1kt51viz	464	17	papillomavirus	papillomavirus	NN
cord-280878-1kt51viz	464	18	HPV-16	HPV-16	NNP
cord-280878-1kt51viz	464	19	and	and	CC
cord-280878-1kt51viz	464	20	HPV-31	HPV-31	NNP
cord-280878-1kt51viz	464	21	,	,	,
cord-280878-1kt51viz	464	22	where	where	WRB
cord-280878-1kt51viz	464	23	it	-PRON-	PRP
cord-280878-1kt51viz	464	24	is	be	VBZ
cord-280878-1kt51viz	464	25	similarly	similarly	RB
cord-280878-1kt51viz	464	26	thought	think	VBN
cord-280878-1kt51viz	464	27	to	to	TO
cord-280878-1kt51viz	464	28	regulate	regulate	VB
cord-280878-1kt51viz	464	29	apoptosis	apoptosis	NN
cord-280878-1kt51viz	464	30	(	(	-LRB-
cord-280878-1kt51viz	464	31	Regan	Regan	NNP
cord-280878-1kt51viz	464	32	&	&	CC
cord-280878-1kt51viz	464	33	Laimins	Laimins	NNP
cord-280878-1kt51viz	464	34	,	,	,
cord-280878-1kt51viz	464	35	2008	2008	CD
cord-280878-1kt51viz	464	36	)	)	-RRB-
cord-280878-1kt51viz	464	37	.	.	.
cord-280878-1kt51viz	465	1	JCV	JCV	NNP
cord-280878-1kt51viz	465	2	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	465	3	has	have	VBZ
cord-280878-1kt51viz	465	4	been	be	VBN
cord-280878-1kt51viz	465	5	shown	show	VBN
cord-280878-1kt51viz	465	6	to	to	TO
cord-280878-1kt51viz	465	7	interact	interact	VB
cord-280878-1kt51viz	465	8	with	with	IN
cord-280878-1kt51viz	465	9	a	a	DT
cord-280878-1kt51viz	465	10	number	number	NN
cord-280878-1kt51viz	465	11	of	of	IN
cord-280878-1kt51viz	465	12	cellular	cellular	JJ
cord-280878-1kt51viz	465	13	and	and	CC
cord-280878-1kt51viz	465	14	viral	viral	JJ
cord-280878-1kt51viz	465	15	proteins	protein	NNS
cord-280878-1kt51viz	465	16	(	(	-LRB-
cord-280878-1kt51viz	465	17	Gerits	Gerits	NNP
cord-280878-1kt51viz	465	18	&	&	CC
cord-280878-1kt51viz	465	19	Moens	Moens	NNP
cord-280878-1kt51viz	465	20	,	,	,
cord-280878-1kt51viz	465	21	2012	2012	CD
cord-280878-1kt51viz	465	22	;	;	:
cord-280878-1kt51viz	465	23	Gerits	Gerits	NNP
cord-280878-1kt51viz	465	24	et	et	NNP
cord-280878-1kt51viz	465	25	al	al	NNP
cord-280878-1kt51viz	465	26	.	.	NNP
cord-280878-1kt51viz	465	27	,	,	,
cord-280878-1kt51viz	465	28	2015	2015	CD
cord-280878-1kt51viz	465	29	)	)	-RRB-
cord-280878-1kt51viz	465	30	.	.	.
cord-280878-1kt51viz	466	1	However	however	RB
cord-280878-1kt51viz	466	2	,	,	,
cord-280878-1kt51viz	466	3	despite	despite	IN
cord-280878-1kt51viz	466	4	all	all	PDT
cord-280878-1kt51viz	466	5	these	these	DT
cord-280878-1kt51viz	466	6	intense	intense	JJ
cord-280878-1kt51viz	466	7	research	research	NN
cord-280878-1kt51viz	466	8	,	,	,
cord-280878-1kt51viz	466	9	the	the	DT
cord-280878-1kt51viz	466	10	exact	exact	JJ
cord-280878-1kt51viz	466	11	regulatory	regulatory	JJ
cord-280878-1kt51viz	466	12	function	function	NN
cord-280878-1kt51viz	466	13	of	of	IN
cord-280878-1kt51viz	466	14	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	466	15	in	in	IN
cord-280878-1kt51viz	466	16	viral	viral	JJ
cord-280878-1kt51viz	466	17	replication	replication	NN
cord-280878-1kt51viz	466	18	is	be	VBZ
cord-280878-1kt51viz	466	19	not	not	RB
cord-280878-1kt51viz	466	20	fully	fully	RB
cord-280878-1kt51viz	466	21	understood	understand	VBN
cord-280878-1kt51viz	466	22	.	.	.
cord-280878-1kt51viz	467	1	JCV	JCV	NNP
cord-280878-1kt51viz	467	2	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	467	3	specifically	specifically	RB
cord-280878-1kt51viz	467	4	interacts	interact	VBZ
cord-280878-1kt51viz	467	5	with	with	IN
cord-280878-1kt51viz	467	6	the	the	DT
cord-280878-1kt51viz	467	7	adaptor	adaptor	NN
cord-280878-1kt51viz	467	8	protein	protein	NN
cord-280878-1kt51viz	467	9	complex	complex	NN
cord-280878-1kt51viz	467	10	3	3	CD
cord-280878-1kt51viz	467	11	through	through	IN
cord-280878-1kt51viz	467	12	its	-PRON-	PRP$
cord-280878-1kt51viz	467	13	delta	delta	NN
cord-280878-1kt51viz	467	14	subunit	subunit	NN
cord-280878-1kt51viz	467	15	.	.	.
cord-280878-1kt51viz	468	1	This	this	DT
cord-280878-1kt51viz	468	2	interaction	interaction	NN
cord-280878-1kt51viz	468	3	interrupts	interrupt	VBZ
cord-280878-1kt51viz	468	4	adaptor	adaptor	NN
cord-280878-1kt51viz	468	5	protein	protein	NN
cord-280878-1kt51viz	468	6	complex	complex	NN
cord-280878-1kt51viz	468	7	3-mediated	3-mediated	CD
cord-280878-1kt51viz	468	8	vesicular	vesicular	JJ
cord-280878-1kt51viz	468	9	trafficking	trafficking	NN
cord-280878-1kt51viz	468	10	.	.	.
cord-280878-1kt51viz	469	1	The	the	DT
cord-280878-1kt51viz	469	2	protein	protein	NN
cord-280878-1kt51viz	469	3	is	be	VBZ
cord-280878-1kt51viz	469	4	then	then	RB
cord-280878-1kt51viz	469	5	not	not	RB
cord-280878-1kt51viz	469	6	targeted	target	VBN
cord-280878-1kt51viz	469	7	to	to	IN
cord-280878-1kt51viz	469	8	the	the	DT
cord-280878-1kt51viz	469	9	lysosomal	lysosomal	JJ
cord-280878-1kt51viz	469	10	degradation	degradation	NN
cord-280878-1kt51viz	469	11	pathway	pathway	NN
cord-280878-1kt51viz	469	12	,	,	,
cord-280878-1kt51viz	469	13	while	while	IN
cord-280878-1kt51viz	469	14	allowing	allow	VBG
cord-280878-1kt51viz	469	15	transport	transport	NN
cord-280878-1kt51viz	469	16	of	of	IN
cord-280878-1kt51viz	469	17	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	469	18	to	to	IN
cord-280878-1kt51viz	469	19	the	the	DT
cord-280878-1kt51viz	469	20	plasma	plasma	NN
cord-280878-1kt51viz	469	21	membrane	membrane	NN
cord-280878-1kt51viz	469	22	.	.	.
cord-280878-1kt51viz	470	1	The	the	DT
cord-280878-1kt51viz	470	2	findings	finding	NNS
cord-280878-1kt51viz	470	3	suggest	suggest	VBP
cord-280878-1kt51viz	470	4	that	that	IN
cord-280878-1kt51viz	470	5	the	the	DT
cord-280878-1kt51viz	470	6	viroporins	viroporin	NNS
cord-280878-1kt51viz	470	7	of	of	IN
cord-280878-1kt51viz	470	8	other	other	JJ
cord-280878-1kt51viz	470	9	viruses	virus	NNS
cord-280878-1kt51viz	470	10	may	may	MD
cord-280878-1kt51viz	470	11	also	also	RB
cord-280878-1kt51viz	470	12	be	be	VB
cord-280878-1kt51viz	470	13	highly	highly	RB
cord-280878-1kt51viz	470	14	regulated	regulate	VBN
cord-280878-1kt51viz	470	15	by	by	IN
cord-280878-1kt51viz	470	16	specific	specific	JJ
cord-280878-1kt51viz	470	17	interactions	interaction	NNS
cord-280878-1kt51viz	470	18	with	with	IN
cord-280878-1kt51viz	470	19	host	host	NN
cord-280878-1kt51viz	470	20	cell	cell	NN
cord-280878-1kt51viz	470	21	proteins	protein	NNS
cord-280878-1kt51viz	471	1	(	(	-LRB-
cord-280878-1kt51viz	471	2	Suzuki	Suzuki	NNP
cord-280878-1kt51viz	471	3	et	et	FW
cord-280878-1kt51viz	471	4	al	al	NNP
cord-280878-1kt51viz	471	5	.	.	NNP
cord-280878-1kt51viz	471	6	,	,	,
cord-280878-1kt51viz	471	7	2013	2013	CD
cord-280878-1kt51viz	471	8	)	)	-RRB-
cord-280878-1kt51viz	471	9	.	.	.
cord-280878-1kt51viz	472	1	These	these	DT
cord-280878-1kt51viz	472	2	pathologically	pathologically	RB
cord-280878-1kt51viz	472	3	relevant	relevant	JJ
cord-280878-1kt51viz	472	4	interactions	interaction	NNS
cord-280878-1kt51viz	472	5	between	between	IN
cord-280878-1kt51viz	472	6	viroporins	viroporin	NNS
cord-280878-1kt51viz	472	7	and	and	CC
cord-280878-1kt51viz	472	8	their	-PRON-	PRP$
cord-280878-1kt51viz	472	9	associated	associate	VBN
cord-280878-1kt51viz	472	10	viral	viral	JJ
cord-280878-1kt51viz	472	11	and	and	CC
cord-280878-1kt51viz	472	12	host	host	NN
cord-280878-1kt51viz	472	13	proteins	protein	NNS
cord-280878-1kt51viz	472	14	present	present	VBP
cord-280878-1kt51viz	472	15	an	an	DT
cord-280878-1kt51viz	472	16	attractive	attractive	JJ
cord-280878-1kt51viz	472	17	therapeutic	therapeutic	JJ
cord-280878-1kt51viz	472	18	target	target	NN
cord-280878-1kt51viz	472	19	for	for	IN
cord-280878-1kt51viz	472	20	disruption	disruption	NN
cord-280878-1kt51viz	472	21	by	by	IN
cord-280878-1kt51viz	472	22	small	small	JJ
cord-280878-1kt51viz	472	23	molecules	molecule	NNS
cord-280878-1kt51viz	472	24	,	,	,
cord-280878-1kt51viz	472	25	as	as	RB
cord-280878-1kt51viz	472	26	well	well	RB
cord-280878-1kt51viz	472	27	as	as	IN
cord-280878-1kt51viz	472	28	peptides	peptide	NNS
cord-280878-1kt51viz	472	29	stabilized	stabilize	VBN
cord-280878-1kt51viz	472	30	by	by	IN
cord-280878-1kt51viz	472	31	internal	internal	JJ
cord-280878-1kt51viz	472	32	covalent	covalent	JJ
cord-280878-1kt51viz	472	33	linkage	linkage	NN
cord-280878-1kt51viz	472	34	(	(	-LRB-
cord-280878-1kt51viz	472	35	stapled	staple	VBN
cord-280878-1kt51viz	472	36	peptides	peptide	NNS
cord-280878-1kt51viz	472	37	)	)	-RRB-
cord-280878-1kt51viz	473	1	(	(	-LRB-
cord-280878-1kt51viz	473	2	Walensky	Walensky	NNP
cord-280878-1kt51viz	473	3	&	&	CC
cord-280878-1kt51viz	473	4	Bird	Bird	NNP
cord-280878-1kt51viz	473	5	,	,	,
cord-280878-1kt51viz	473	6	2014	2014	CD
cord-280878-1kt51viz	473	7	)	)	-RRB-
cord-280878-1kt51viz	473	8	.	.	.
cord-280878-1kt51viz	474	1	In	in	IN
cord-280878-1kt51viz	474	2	principle	principle	NN
cord-280878-1kt51viz	474	3	,	,	,
cord-280878-1kt51viz	474	4	both	both	CC
cord-280878-1kt51viz	474	5	the	the	DT
cord-280878-1kt51viz	474	6	transmembrane	transmembrane	NNP
cord-280878-1kt51viz	474	7	and	and	CC
cord-280878-1kt51viz	474	8	extramembrane	extramembrane	NNP
cord-280878-1kt51viz	474	9	domains	domain	NNS
cord-280878-1kt51viz	474	10	of	of	IN
cord-280878-1kt51viz	474	11	viroporins	viroporin	NNS
cord-280878-1kt51viz	474	12	can	can	MD
cord-280878-1kt51viz	474	13	be	be	VB
cord-280878-1kt51viz	474	14	potential	potential	JJ
cord-280878-1kt51viz	474	15	templates	template	NNS
cord-280878-1kt51viz	474	16	for	for	IN
cord-280878-1kt51viz	474	17	peptide	peptide	NN
cord-280878-1kt51viz	474	18	-	-	HYPH
cord-280878-1kt51viz	474	19	based	base	VBN
cord-280878-1kt51viz	474	20	modulators	modulator	NNS
cord-280878-1kt51viz	474	21	.	.	.
cord-280878-1kt51viz	475	1	For	for	IN
cord-280878-1kt51viz	475	2	example	example	NN
cord-280878-1kt51viz	475	3	,	,	,
cord-280878-1kt51viz	475	4	one	one	PRP
cord-280878-1kt51viz	475	5	could	could	MD
cord-280878-1kt51viz	475	6	design	design	VB
cord-280878-1kt51viz	475	7	a	a	DT
cord-280878-1kt51viz	475	8	stapled	staple	VBN
cord-280878-1kt51viz	475	9	peptide	peptide	NN
cord-280878-1kt51viz	475	10	mimicking	mimic	VBG
cord-280878-1kt51viz	475	11	the	the	DT
cord-280878-1kt51viz	475	12	α	α	NN
cord-280878-1kt51viz	475	13	-	-	HYPH
cord-280878-1kt51viz	475	14	helical	helical	JJ
cord-280878-1kt51viz	475	15	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	475	16	domain	domain	NN
cord-280878-1kt51viz	475	17	of	of	IN
cord-280878-1kt51viz	475	18	the	the	DT
cord-280878-1kt51viz	475	19	SH	SH	NNP
cord-280878-1kt51viz	475	20	protein	protein	NN
cord-280878-1kt51viz	475	21	to	to	TO
cord-280878-1kt51viz	475	22	disrupt	disrupt	VB
cord-280878-1kt51viz	475	23	the	the	DT
cord-280878-1kt51viz	475	24	interactions	interaction	NNS
cord-280878-1kt51viz	475	25	between	between	IN
cord-280878-1kt51viz	475	26	SH	sh	NN
cord-280878-1kt51viz	475	27	and	and	CC
cord-280878-1kt51viz	475	28	a	a	DT
cord-280878-1kt51viz	475	29	variant	variant	NN
cord-280878-1kt51viz	475	30	of	of	IN
cord-280878-1kt51viz	475	31	the	the	DT
cord-280878-1kt51viz	475	32	death	death	NN
cord-280878-1kt51viz	475	33	effector	effector	NN
cord-280878-1kt51viz	475	34	domain	domain	NN
cord-280878-1kt51viz	475	35	(	(	-LRB-
cord-280878-1kt51viz	475	36	vDED	vded	NN
cord-280878-1kt51viz	475	37	)	)	-RRB-
cord-280878-1kt51viz	475	38	of	of	IN
cord-280878-1kt51viz	475	39	BAP31	BAP31	NNP
cord-280878-1kt51viz	475	40	,	,	,
cord-280878-1kt51viz	475	41	which	which	WDT
cord-280878-1kt51viz	475	42	would	would	MD
cord-280878-1kt51viz	475	43	lead	lead	VB
cord-280878-1kt51viz	475	44	to	to	IN
cord-280878-1kt51viz	475	45	enhanced	enhance	VBN
cord-280878-1kt51viz	475	46	apoptosis	apoptosis	NN
cord-280878-1kt51viz	475	47	and	and	CC
cord-280878-1kt51viz	475	48	cell	cell	NN
cord-280878-1kt51viz	475	49	death	death	NN
cord-280878-1kt51viz	475	50	of	of	IN
cord-280878-1kt51viz	475	51	infected	infected	JJ
cord-280878-1kt51viz	475	52	cells	cell	NNS
cord-280878-1kt51viz	475	53	.	.	.
cord-280878-1kt51viz	476	1	One	one	PRP
cord-280878-1kt51viz	476	2	could	could	MD
cord-280878-1kt51viz	476	3	also	also	RB
cord-280878-1kt51viz	476	4	mimic	mimic	VB
cord-280878-1kt51viz	476	5	the	the	DT
cord-280878-1kt51viz	476	6	transmembrane	transmembrane	NN
cord-280878-1kt51viz	476	7	domain	domain	NN
cord-280878-1kt51viz	476	8	to	to	TO
cord-280878-1kt51viz	476	9	disrupt	disrupt	VB
cord-280878-1kt51viz	476	10	monomer	monomer	NN
cord-280878-1kt51viz	476	11	-	-	HYPH
cord-280878-1kt51viz	476	12	monomer	monomer	NN
cord-280878-1kt51viz	476	13	interactions	interaction	NNS
cord-280878-1kt51viz	476	14	,	,	,
cord-280878-1kt51viz	476	15	as	as	IN
cord-280878-1kt51viz	476	16	shown	show	VBN
cord-280878-1kt51viz	476	17	recently	recently	RB
cord-280878-1kt51viz	476	18	for	for	IN
cord-280878-1kt51viz	476	19	Halobacterium	Halobacterium	NNP
cord-280878-1kt51viz	476	20	salinarum	salinarum	NNP
cord-280878-1kt51viz	476	21	where	where	WRB
cord-280878-1kt51viz	476	22	efflux	efflux	NN
cord-280878-1kt51viz	476	23	by	by	IN
cord-280878-1kt51viz	476	24	a	a	DT
cord-280878-1kt51viz	476	25	small	small	JJ
cord-280878-1kt51viz	476	26	multidrug	multidrug	NN
cord-280878-1kt51viz	476	27	resistance	resistance	NN
cord-280878-1kt51viz	476	28	protein	protein	NN
cord-280878-1kt51viz	476	29	was	be	VBD
cord-280878-1kt51viz	476	30	inhibited	inhibit	VBN
cord-280878-1kt51viz	476	31	with	with	IN
cord-280878-1kt51viz	476	32	peptides	peptide	NNS
cord-280878-1kt51viz	476	33	targeting	target	VBG
cord-280878-1kt51viz	476	34	its	-PRON-	PRP$
cord-280878-1kt51viz	476	35	TM	TM	NNP
cord-280878-1kt51viz	476	36	domain	domain	NN
cord-280878-1kt51viz	476	37	(	(	-LRB-
cord-280878-1kt51viz	476	38	Bellmann	Bellmann	NNP
cord-280878-1kt51viz	476	39	-	-	HYPH
cord-280878-1kt51viz	476	40	Sickert	Sickert	NNP
cord-280878-1kt51viz	476	41	,	,	,
cord-280878-1kt51viz	476	42	Stone	Stone	NNP
cord-280878-1kt51viz	476	43	,	,	,
cord-280878-1kt51viz	476	44	Poulsen	Poulsen	NNP
cord-280878-1kt51viz	476	45	,	,	,
cord-280878-1kt51viz	476	46	&	&	CC
cord-280878-1kt51viz	476	47	Deber	Deber	NNP
cord-280878-1kt51viz	476	48	,	,	,
cord-280878-1kt51viz	476	49	2014	2014	CD
cord-280878-1kt51viz	476	50	)	)	-RRB-
cord-280878-1kt51viz	476	51	.	.	.
cord-280878-1kt51viz	477	1	In	in	IN
cord-280878-1kt51viz	477	2	the	the	DT
cord-280878-1kt51viz	477	3	case	case	NN
cord-280878-1kt51viz	477	4	of	of	IN
cord-280878-1kt51viz	477	5	viroporins	viroporin	NNS
cord-280878-1kt51viz	477	6	,	,	,
cord-280878-1kt51viz	477	7	the	the	DT
cord-280878-1kt51viz	477	8	disruption	disruption	NN
cord-280878-1kt51viz	477	9	of	of	IN
cord-280878-1kt51viz	477	10	the	the	DT
cord-280878-1kt51viz	477	11	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	477	12	status	status	NN
cord-280878-1kt51viz	477	13	would	would	MD
cord-280878-1kt51viz	477	14	abolish	abolish	VB
cord-280878-1kt51viz	477	15	channel	channel	NN
cord-280878-1kt51viz	477	16	activity	activity	NN
cord-280878-1kt51viz	477	17	,	,	,
cord-280878-1kt51viz	477	18	a	a	DT
cord-280878-1kt51viz	477	19	classical	classical	JJ
cord-280878-1kt51viz	477	20	strategy	strategy	NN
cord-280878-1kt51viz	477	21	revisited	revisit	VBN
cord-280878-1kt51viz	477	22	with	with	IN
cord-280878-1kt51viz	477	23	a	a	DT
cord-280878-1kt51viz	477	24	different	different	JJ
cord-280878-1kt51viz	477	25	approach	approach	NN
cord-280878-1kt51viz	477	26	.	.	.
cord-280878-1kt51viz	478	1	However	however	RB
cord-280878-1kt51viz	478	2	,	,	,
cord-280878-1kt51viz	478	3	more	more	RBR
cord-280878-1kt51viz	478	4	detailed	detailed	JJ
cord-280878-1kt51viz	478	5	mechanistic	mechanistic	JJ
cord-280878-1kt51viz	478	6	information	information	NN
cord-280878-1kt51viz	478	7	should	should	MD
cord-280878-1kt51viz	478	8	be	be	VB
cord-280878-1kt51viz	478	9	available	available	JJ
cord-280878-1kt51viz	478	10	before	before	IN
cord-280878-1kt51viz	478	11	these	these	DT
cord-280878-1kt51viz	478	12	conceptual	conceptual	JJ
cord-280878-1kt51viz	478	13	strategies	strategy	NNS
cord-280878-1kt51viz	478	14	can	can	MD
cord-280878-1kt51viz	478	15	be	be	VB
cord-280878-1kt51viz	478	16	widely	widely	RB
cord-280878-1kt51viz	478	17	used	use	VBN
cord-280878-1kt51viz	478	18	.	.	.
cord-280878-1kt51viz	479	1	Generation	generation	NN
cord-280878-1kt51viz	479	2	and	and	CC
cord-280878-1kt51viz	479	3	characterization	characterization	NN
cord-280878-1kt51viz	479	4	of	of	IN
cord-280878-1kt51viz	479	5	recombinant	recombinant	JJ
cord-280878-1kt51viz	479	6	influenza	influenza	NN
cord-280878-1kt51viz	479	7	A	a	NN
cord-280878-1kt51viz	479	8	(	(	-LRB-
cord-280878-1kt51viz	479	9	H1N1	H1N1	NNP
cord-280878-1kt51viz	479	10	)	)	-RRB-
cord-280878-1kt51viz	479	11	viruses	viruse	VBZ
cord-280878-1kt51viz	479	12	harboring	harbor	VBG
cord-280878-1kt51viz	479	13	amantadine	amantadine	NNP
cord-280878-1kt51viz	479	14	resistance	resistance	NN
cord-280878-1kt51viz	479	15	mutations	mutation	NNS
cord-280878-1kt51viz	479	16	Structure	structure	NN
cord-280878-1kt51viz	479	17	and	and	CC
cord-280878-1kt51viz	479	18	mechanism	mechanism	NN
cord-280878-1kt51viz	479	19	of	of	IN
cord-280878-1kt51viz	479	20	proton	proton	NN
cord-280878-1kt51viz	479	21	transport	transport	NN
cord-280878-1kt51viz	479	22	through	through	IN
cord-280878-1kt51viz	479	23	the	the	DT
cord-280878-1kt51viz	479	24	transmembrane	transmembrane	NN
cord-280878-1kt51viz	479	25	tetrameric	tetrameric	JJ
cord-280878-1kt51viz	479	26	M2	M2	NNP
cord-280878-1kt51viz	479	27	protein	protein	NN
cord-280878-1kt51viz	479	28	bundle	bundle	NN
cord-280878-1kt51viz	479	29	of	of	IN
cord-280878-1kt51viz	479	30	the	the	DT
cord-280878-1kt51viz	479	31	influenza	influenza	NN
cord-280878-1kt51viz	479	32	A	a	DT
cord-280878-1kt51viz	479	33	virus	virus	NN
cord-280878-1kt51viz	479	34	Viroporin	Viroporin	NNP
cord-280878-1kt51viz	479	35	-	-	HYPH
cord-280878-1kt51viz	479	36	mediated	mediate	VBN
cord-280878-1kt51viz	479	37	membrane	membrane	NN
cord-280878-1kt51viz	479	38	permeabilization	permeabilization	NN
cord-280878-1kt51viz	479	39	.	.	.
cord-280878-1kt51viz	480	1	Pore	pore	NN
cord-280878-1kt51viz	480	2	formation	formation	NN
cord-280878-1kt51viz	480	3	by	by	IN
cord-280878-1kt51viz	480	4	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	480	5	poliovirus	poliovirus	NN
cord-280878-1kt51viz	480	6	2B	2b	CD
cord-280878-1kt51viz	480	7	protein	protein	NN
cord-280878-1kt51viz	480	8	Poliovirus	Poliovirus	NNP
cord-280878-1kt51viz	480	9	protein	protein	NN
cord-280878-1kt51viz	480	10	2BC	2bc	NN
cord-280878-1kt51viz	480	11	increases	increase	VBZ
cord-280878-1kt51viz	480	12	cytosolic	cytosolic	JJ
cord-280878-1kt51viz	480	13	free	free	JJ
cord-280878-1kt51viz	480	14	calcium	calcium	NN
cord-280878-1kt51viz	480	15	concentrations	concentration	NNS
cord-280878-1kt51viz	481	1	Engineering	engineer	VBG
cord-280878-1kt51viz	481	2	a	a	DT
cord-280878-1kt51viz	481	3	replication	replication	NN
cord-280878-1kt51viz	481	4	-	-	HYPH
cord-280878-1kt51viz	481	5	competent	competent	JJ
cord-280878-1kt51viz	481	6	,	,	,
cord-280878-1kt51viz	481	7	propagation	propagation	NN
cord-280878-1kt51viz	481	8	-	-	HYPH
cord-280878-1kt51viz	481	9	defective	defective	JJ
cord-280878-1kt51viz	481	10	middle	middle	NNP
cord-280878-1kt51viz	481	11	east	east	NNP
cord-280878-1kt51viz	481	12	respiratory	respiratory	JJ
cord-280878-1kt51viz	481	13	syndrome	syndrome	NN
cord-280878-1kt51viz	481	14	coronavirus	coronavirus	NN
cord-280878-1kt51viz	481	15	as	as	IN
cord-280878-1kt51viz	481	16	a	a	DT
cord-280878-1kt51viz	481	17	vaccine	vaccine	NN
cord-280878-1kt51viz	481	18	candidate	candidate	NN
cord-280878-1kt51viz	481	19	Demonstration	Demonstration	NNP
cord-280878-1kt51viz	481	20	that	that	IN
cord-280878-1kt51viz	481	21	cftr	cftr	NNP
cord-280878-1kt51viz	481	22	is	be	VBZ
cord-280878-1kt51viz	481	23	a	a	DT
cord-280878-1kt51viz	481	24	chloride	chloride	NN
cord-280878-1kt51viz	481	25	channel	channel	NN
cord-280878-1kt51viz	481	26	by	by	IN
cord-280878-1kt51viz	481	27	alteration	alteration	NN
cord-280878-1kt51viz	481	28	of	of	IN
cord-280878-1kt51viz	481	29	its	-PRON-	PRP$
cord-280878-1kt51viz	481	30	anion	anion	NN
cord-280878-1kt51viz	481	31	selectivity	selectivity	NN
cord-280878-1kt51viz	481	32	A	a	DT
cord-280878-1kt51viz	481	33	strategy	strategy	NN
cord-280878-1kt51viz	481	34	to	to	TO
cord-280878-1kt51viz	481	35	estimate	estimate	VB
cord-280878-1kt51viz	481	36	unknown	unknown	JJ
cord-280878-1kt51viz	481	37	viral	viral	JJ
cord-280878-1kt51viz	481	38	diversity	diversity	NN
cord-280878-1kt51viz	481	39	in	in	IN
cord-280878-1kt51viz	481	40	mammals	mammal	NNS
cord-280878-1kt51viz	481	41	Topology	topology	NN
cord-280878-1kt51viz	481	42	and	and	CC
cord-280878-1kt51viz	481	43	biological	biological	JJ
cord-280878-1kt51viz	481	44	function	function	NN
cord-280878-1kt51viz	481	45	of	of	IN
cord-280878-1kt51viz	481	46	enterovirus	enterovirus	NN
cord-280878-1kt51viz	481	47	non	non	JJ
cord-280878-1kt51viz	481	48	-	-	JJ
cord-280878-1kt51viz	481	49	structural	structural	JJ
cord-280878-1kt51viz	481	50	protein	protein	NN
cord-280878-1kt51viz	481	51	2B	2b	CD
cord-280878-1kt51viz	481	52	as	as	IN
cord-280878-1kt51viz	481	53	a	a	DT
cord-280878-1kt51viz	481	54	member	member	NN
cord-280878-1kt51viz	481	55	of	of	IN
cord-280878-1kt51viz	481	56	the	the	DT
cord-280878-1kt51viz	481	57	viroporin	viroporin	NNP
cord-280878-1kt51viz	481	58	family	family	NN
cord-280878-1kt51viz	481	59	Design	Design	NNP
cord-280878-1kt51viz	481	60	and	and	CC
cord-280878-1kt51viz	481	61	pharmacological	pharmacological	JJ
cord-280878-1kt51viz	481	62	characterization	characterization	NN
cord-280878-1kt51viz	481	63	of	of	IN
cord-280878-1kt51viz	481	64	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	481	65	of	of	IN
cord-280878-1kt51viz	481	66	amantadine	amantadine	NN
cord-280878-1kt51viz	481	67	-	-	HYPH
cord-280878-1kt51viz	481	68	resistant	resistant	JJ
cord-280878-1kt51viz	481	69	mutants	mutant	NNS
cord-280878-1kt51viz	481	70	of	of	IN
cord-280878-1kt51viz	481	71	the	the	DT
cord-280878-1kt51viz	481	72	M2	M2	NNP
cord-280878-1kt51viz	481	73	Ion	Ion	NNP
cord-280878-1kt51viz	481	74	channel	channel	NN
cord-280878-1kt51viz	481	75	of	of	IN
cord-280878-1kt51viz	481	76	influenza	influenza	NN
cord-280878-1kt51viz	481	77	A	a	DT
cord-280878-1kt51viz	481	78	virus	virus	NN
cord-280878-1kt51viz	481	79	Purification	purification	NN
cord-280878-1kt51viz	481	80	and	and	CC
cord-280878-1kt51viz	481	81	functional	functional	JJ
cord-280878-1kt51viz	481	82	reconstitution	reconstitution	NN
cord-280878-1kt51viz	481	83	of	of	IN
cord-280878-1kt51viz	481	84	the	the	DT
cord-280878-1kt51viz	481	85	cystic	cystic	JJ
cord-280878-1kt51viz	481	86	-	-	HYPH
cord-280878-1kt51viz	481	87	fibrosis	fibrosis	NN
cord-280878-1kt51viz	481	88	transmembrane	transmembrane	NN
cord-280878-1kt51viz	481	89	conductance	conductance	NN
cord-280878-1kt51viz	481	90	regulator	regulator	NN
cord-280878-1kt51viz	481	91	(	(	-LRB-
cord-280878-1kt51viz	481	92	cftr	cftr	NNP
cord-280878-1kt51viz	481	93	)	)	-RRB-
cord-280878-1kt51viz	481	94	Efflux	Efflux	NNP
cord-280878-1kt51viz	481	95	by	by	IN
cord-280878-1kt51viz	481	96	small	small	JJ
cord-280878-1kt51viz	481	97	multidrug	multidrug	NN
cord-280878-1kt51viz	481	98	resistance	resistance	NN
cord-280878-1kt51viz	481	99	proteins	protein	NNS
cord-280878-1kt51viz	481	100	is	be	VBZ
cord-280878-1kt51viz	481	101	inhibited	inhibit	VBN
cord-280878-1kt51viz	481	102	by	by	IN
cord-280878-1kt51viz	481	103	membrane	membrane	NN
cord-280878-1kt51viz	481	104	-	-	HYPH
cord-280878-1kt51viz	481	105	interactive	interactive	JJ
cord-280878-1kt51viz	481	106	helix	helix	NN
cord-280878-1kt51viz	481	107	-	-	HYPH
cord-280878-1kt51viz	481	108	stapled	staple	VBN
cord-280878-1kt51viz	481	109	peptides	peptide	NNS
cord-280878-1kt51viz	481	110	Docking	Docking	NNP
cord-280878-1kt51viz	481	111	assay	assay	NN
cord-280878-1kt51viz	481	112	of	of	IN
cord-280878-1kt51viz	481	113	small	small	JJ
cord-280878-1kt51viz	481	114	molecule	molecule	NN
cord-280878-1kt51viz	481	115	antivirals	antiviral	NNS
cord-280878-1kt51viz	481	116	to	to	IN
cord-280878-1kt51viz	481	117	p7	p7	RB
cord-280878-1kt51viz	481	118	of	of	IN
cord-280878-1kt51viz	481	119	HCV	HCV	NNP
cord-280878-1kt51viz	481	120	Mucosal	Mucosal	NNP
cord-280878-1kt51viz	481	121	delivery	delivery	NN
cord-280878-1kt51viz	481	122	of	of	IN
cord-280878-1kt51viz	481	123	a	a	DT
cord-280878-1kt51viz	481	124	double	double	JJ
cord-280878-1kt51viz	481	125	-	-	HYPH
cord-280878-1kt51viz	481	126	stapled	stapled	JJ
cord-280878-1kt51viz	481	127	RSV	RSV	NNP
cord-280878-1kt51viz	481	128	peptide	peptide	NN
cord-280878-1kt51viz	481	129	prevents	prevent	VBZ
cord-280878-1kt51viz	481	130	nasopulmonary	nasopulmonary	JJ
cord-280878-1kt51viz	481	131	infection	infection	NN
cord-280878-1kt51viz	482	1	Ion	ion	NN
cord-280878-1kt51viz	482	2	channel	channel	NN
cord-280878-1kt51viz	482	3	activity	activity	NN
cord-280878-1kt51viz	482	4	of	of	IN
cord-280878-1kt51viz	482	5	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	482	6	Vpu	Vpu	NNP
cord-280878-1kt51viz	482	7	is	be	VBZ
cord-280878-1kt51viz	482	8	dispensable	dispensable	JJ
cord-280878-1kt51viz	482	9	for	for	IN
cord-280878-1kt51viz	482	10	counteraction	counteraction	NN
cord-280878-1kt51viz	482	11	of	of	IN
cord-280878-1kt51viz	482	12	CD317	CD317	NNP
cord-280878-1kt51viz	482	13	A	a	DT
cord-280878-1kt51viz	482	14	concerted	concerted	JJ
cord-280878-1kt51viz	482	15	action	action	NN
cord-280878-1kt51viz	482	16	of	of	IN
cord-280878-1kt51viz	482	17	hepatitis	hepatitis	NN
cord-280878-1kt51viz	482	18	C	C	NNP
cord-280878-1kt51viz	482	19	virus	virus	NN
cord-280878-1kt51viz	482	20	P7	p7	NN
cord-280878-1kt51viz	482	21	and	and	CC
cord-280878-1kt51viz	482	22	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	482	23	protein	protein	NN
cord-280878-1kt51viz	482	24	2	2	CD
cord-280878-1kt51viz	482	25	regulates	regulate	VBZ
cord-280878-1kt51viz	482	26	core	core	NN
cord-280878-1kt51viz	482	27	localization	localization	NN
cord-280878-1kt51viz	482	28	at	at	IN
cord-280878-1kt51viz	482	29	the	the	DT
cord-280878-1kt51viz	482	30	endoplasmic	endoplasmic	NN
cord-280878-1kt51viz	482	31	reticulum	reticulum	NN
cord-280878-1kt51viz	482	32	and	and	CC
cord-280878-1kt51viz	482	33	virus	virus	NN
cord-280878-1kt51viz	482	34	assembly	assembly	NN
cord-280878-1kt51viz	483	1	The	the	DT
cord-280878-1kt51viz	483	2	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	483	3	Vpu	Vpu	NNP
cord-280878-1kt51viz	483	4	protein	protein	NN
cord-280878-1kt51viz	483	5	:	:	:
cord-280878-1kt51viz	484	1	A	a	DT
cord-280878-1kt51viz	484	2	multifunctional	multifunctional	JJ
cord-280878-1kt51viz	484	3	enhancer	enhancer	NN
cord-280878-1kt51viz	484	4	of	of	IN
cord-280878-1kt51viz	484	5	viral	viral	JJ
cord-280878-1kt51viz	484	6	particle	particle	NN
cord-280878-1kt51viz	484	7	release	release	NN
cord-280878-1kt51viz	484	8	Incidence	incidence	NN
cord-280878-1kt51viz	484	9	of	of	IN
cord-280878-1kt51viz	484	10	adamantane	adamantane	NNP
cord-280878-1kt51viz	484	11	resistance	resistance	NN
cord-280878-1kt51viz	484	12	among	among	IN
cord-280878-1kt51viz	484	13	influenza	influenza	NN
cord-280878-1kt51viz	484	14	A	a	NN
cord-280878-1kt51viz	484	15	(	(	-LRB-
cord-280878-1kt51viz	484	16	H3N2	H3N2	NNP
cord-280878-1kt51viz	484	17	)	)	-RRB-
cord-280878-1kt51viz	484	18	viruses	virus	NNS
cord-280878-1kt51viz	484	19	isolated	isolate	VBN
cord-280878-1kt51viz	484	20	worldwide	worldwide	RB
cord-280878-1kt51viz	484	21	from	from	IN
cord-280878-1kt51viz	484	22	1994	1994	CD
cord-280878-1kt51viz	484	23	to	to	IN
cord-280878-1kt51viz	484	24	2005	2005	CD
cord-280878-1kt51viz	484	25	:	:	:
cord-280878-1kt51viz	484	26	A	a	DT
cord-280878-1kt51viz	484	27	cause	cause	NN
cord-280878-1kt51viz	484	28	for	for	IN
cord-280878-1kt51viz	484	29	concern	concern	NN
cord-280878-1kt51viz	484	30	Adamantane	Adamantane	NNP
cord-280878-1kt51viz	484	31	resistance	resistance	NN
cord-280878-1kt51viz	484	32	among	among	IN
cord-280878-1kt51viz	484	33	influenza	influenza	NN
cord-280878-1kt51viz	484	34	A	a	DT
cord-280878-1kt51viz	484	35	viruses	virus	NNS
cord-280878-1kt51viz	484	36	isolated	isolate	VBN
cord-280878-1kt51viz	484	37	early	early	RB
cord-280878-1kt51viz	484	38	during	during	IN
cord-280878-1kt51viz	484	39	the	the	DT
cord-280878-1kt51viz	484	40	2005	2005	CD
cord-280878-1kt51viz	484	41	-	-	SYM
cord-280878-1kt51viz	484	42	2006	2006	CD
cord-280878-1kt51viz	484	43	influenza	influenza	NN
cord-280878-1kt51viz	484	44	season	season	NN
cord-280878-1kt51viz	484	45	in	in	IN
cord-280878-1kt51viz	484	46	the	the	DT
cord-280878-1kt51viz	484	47	United	United	NNP
cord-280878-1kt51viz	484	48	States	States	NNP
cord-280878-1kt51viz	484	49	Recombinant	Recombinant	NNP
cord-280878-1kt51viz	484	50	respiratory	respiratory	JJ
cord-280878-1kt51viz	484	51	syncytial	syncytial	JJ
cord-280878-1kt51viz	484	52	virus	virus	NN
cord-280878-1kt51viz	484	53	from	from	IN
cord-280878-1kt51viz	484	54	which	which	WDT
cord-280878-1kt51viz	484	55	the	the	DT
cord-280878-1kt51viz	484	56	entire	entire	JJ
cord-280878-1kt51viz	484	57	SH	sh	NN
cord-280878-1kt51viz	484	58	gene	gene	NN
cord-280878-1kt51viz	484	59	has	have	VBZ
cord-280878-1kt51viz	484	60	been	be	VBN
cord-280878-1kt51viz	484	61	deleted	delete	VBN
cord-280878-1kt51viz	484	62	grows	grow	VBZ
cord-280878-1kt51viz	484	63	efficiently	efficiently	RB
cord-280878-1kt51viz	484	64	in	in	IN
cord-280878-1kt51viz	484	65	cell	cell	NN
cord-280878-1kt51viz	484	66	culture	culture	NN
cord-280878-1kt51viz	484	67	and	and	CC
cord-280878-1kt51viz	484	68	exhibits	exhibit	VBZ
cord-280878-1kt51viz	484	69	site	site	NN
cord-280878-1kt51viz	484	70	-	-	HYPH
cord-280878-1kt51viz	484	71	specific	specific	JJ
cord-280878-1kt51viz	484	72	attenuation	attenuation	NN
cord-280878-1kt51viz	484	73	in	in	IN
cord-280878-1kt51viz	484	74	the	the	DT
cord-280878-1kt51viz	484	75	respiratory	respiratory	JJ
cord-280878-1kt51viz	484	76	tract	tract	NN
cord-280878-1kt51viz	484	77	of	of	IN
cord-280878-1kt51viz	484	78	the	the	DT
cord-280878-1kt51viz	484	79	mouse	mouse	NN
cord-280878-1kt51viz	484	80	Structure	Structure	NNP
cord-280878-1kt51viz	484	81	of	of	IN
cord-280878-1kt51viz	484	82	the	the	DT
cord-280878-1kt51viz	484	83	amantadine	amantadine	NNP
cord-280878-1kt51viz	484	84	binding	bind	VBG
cord-280878-1kt51viz	484	85	site	site	NN
cord-280878-1kt51viz	484	86	of	of	IN
cord-280878-1kt51viz	484	87	influenza	influenza	NN
cord-280878-1kt51viz	484	88	M2	m2	JJ
cord-280878-1kt51viz	484	89	proton	proton	NN
cord-280878-1kt51viz	484	90	channels	channel	NNS
cord-280878-1kt51viz	484	91	in	in	IN
cord-280878-1kt51viz	484	92	lipid	lipid	NN
cord-280878-1kt51viz	484	93	bilayers	bilayer	NNS
cord-280878-1kt51viz	484	94	Membrane	membrane	NN
cord-280878-1kt51viz	484	95	-	-	HYPH
cord-280878-1kt51viz	484	96	dependent	dependent	JJ
cord-280878-1kt51viz	484	97	effects	effect	NNS
cord-280878-1kt51viz	484	98	of	of	IN
cord-280878-1kt51viz	484	99	a	a	DT
cord-280878-1kt51viz	484	100	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	484	101	helix	helix	NN
cord-280878-1kt51viz	484	102	on	on	IN
cord-280878-1kt51viz	484	103	the	the	DT
cord-280878-1kt51viz	484	104	structure	structure	NN
cord-280878-1kt51viz	484	105	and	and	CC
cord-280878-1kt51viz	484	106	drug	drug	NN
cord-280878-1kt51viz	484	107	binding	binding	NN
cord-280878-1kt51viz	484	108	of	of	IN
cord-280878-1kt51viz	484	109	the	the	DT
cord-280878-1kt51viz	484	110	influenza	influenza	NN
cord-280878-1kt51viz	484	111	virus	virus	NN
cord-280878-1kt51viz	484	112	M2	M2	NNP
cord-280878-1kt51viz	484	113	protein	protein	NN
cord-280878-1kt51viz	484	114	Modification	modification	NN
cord-280878-1kt51viz	484	115	of	of	IN
cord-280878-1kt51viz	484	116	membrane	membrane	NN
cord-280878-1kt51viz	484	117	permeability	permeability	NN
cord-280878-1kt51viz	484	118	by	by	IN
cord-280878-1kt51viz	484	119	animal	animal	NN
cord-280878-1kt51viz	484	120	viruses	virus	NNS
cord-280878-1kt51viz	485	1	Subcellular	subcellular	JJ
cord-280878-1kt51viz	485	2	localization	localization	NN
cord-280878-1kt51viz	485	3	and	and	CC
cord-280878-1kt51viz	485	4	topology	topology	NN
cord-280878-1kt51viz	485	5	of	of	IN
cord-280878-1kt51viz	485	6	the	the	DT
cord-280878-1kt51viz	485	7	p7	p7	NNP
cord-280878-1kt51viz	485	8	polypeptide	polypeptide	NN
cord-280878-1kt51viz	485	9	of	of	IN
cord-280878-1kt51viz	485	10	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	485	11	C	C	NNP
cord-280878-1kt51viz	485	12	virus	virus	NN
cord-280878-1kt51viz	485	13	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	485	14	C	C	NNP
cord-280878-1kt51viz	485	15	virus	virus	NN
cord-280878-1kt51viz	485	16	p7	p7	RB
cord-280878-1kt51viz	485	17	membrane	membrane	NN
cord-280878-1kt51viz	485	18	protein	protein	NN
cord-280878-1kt51viz	485	19	quasispecies	quasispecie	VBZ
cord-280878-1kt51viz	485	20	variability	variability	NN
cord-280878-1kt51viz	485	21	in	in	IN
cord-280878-1kt51viz	485	22	chronically	chronically	RB
cord-280878-1kt51viz	485	23	infected	infect	VBN
cord-280878-1kt51viz	485	24	patients	patient	NNS
cord-280878-1kt51viz	485	25	treated	treat	VBN
cord-280878-1kt51viz	485	26	with	with	IN
cord-280878-1kt51viz	485	27	interferon	interferon	NN
cord-280878-1kt51viz	485	28	and	and	CC
cord-280878-1kt51viz	485	29	ribavirin	ribavirin	NN
cord-280878-1kt51viz	485	30	,	,	,
cord-280878-1kt51viz	485	31	with	with	IN
cord-280878-1kt51viz	485	32	or	or	CC
cord-280878-1kt51viz	485	33	without	without	IN
cord-280878-1kt51viz	485	34	amantadine	amantadine	NNP
cord-280878-1kt51viz	486	1	The	the	DT
cord-280878-1kt51viz	486	2	influenza	influenza	NN
cord-280878-1kt51viz	486	3	virus	virus	NN
cord-280878-1kt51viz	486	4	M2	m2	NN
cord-280878-1kt51viz	486	5	protein	protein	NN
cord-280878-1kt51viz	486	6	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	486	7	tail	tail	NN
cord-280878-1kt51viz	486	8	interacts	interact	VBZ
cord-280878-1kt51viz	486	9	with	with	IN
cord-280878-1kt51viz	486	10	the	the	DT
cord-280878-1kt51viz	486	11	M1	M1	NNP
cord-280878-1kt51viz	486	12	protein	protein	NN
cord-280878-1kt51viz	486	13	and	and	CC
cord-280878-1kt51viz	486	14	influences	influence	VBZ
cord-280878-1kt51viz	486	15	virus	virus	NN
cord-280878-1kt51viz	486	16	assembly	assembly	NN
cord-280878-1kt51viz	486	17	at	at	IN
cord-280878-1kt51viz	486	18	the	the	DT
cord-280878-1kt51viz	486	19	site	site	NN
cord-280878-1kt51viz	486	20	of	of	IN
cord-280878-1kt51viz	486	21	virus	virus	NN
cord-280878-1kt51viz	486	22	budding	bud	VBG
cord-280878-1kt51viz	486	23	Determination	determination	NN
cord-280878-1kt51viz	486	24	of	of	IN
cord-280878-1kt51viz	486	25	pore	pore	NN
cord-280878-1kt51viz	486	26	-	-	HYPH
cord-280878-1kt51viz	486	27	lining	lining	NN
cord-280878-1kt51viz	486	28	residues	residue	NNS
cord-280878-1kt51viz	486	29	in	in	IN
cord-280878-1kt51viz	486	30	the	the	DT
cord-280878-1kt51viz	486	31	hepatitis	hepatitis	NN
cord-280878-1kt51viz	486	32	C	c	NN
cord-280878-1kt51viz	486	33	virus	virus	NN
cord-280878-1kt51viz	486	34	p7	p7	NN
cord-280878-1kt51viz	486	35	protein	protein	NN
cord-280878-1kt51viz	486	36	Assembling	assemble	VBG
cord-280878-1kt51viz	486	37	an	an	DT
cord-280878-1kt51viz	486	38	ion	ion	NN
cord-280878-1kt51viz	486	39	channel	channel	NN
cord-280878-1kt51viz	486	40	:	:	:
cord-280878-1kt51viz	487	1	ORF	ORF	NNP
cord-280878-1kt51viz	487	2	3a	3a	NNP
cord-280878-1kt51viz	487	3	from	from	IN
cord-280878-1kt51viz	487	4	SARS	SARS	NNP
cord-280878-1kt51viz	487	5	-	-	HYPH
cord-280878-1kt51viz	487	6	CoV	CoV	NNP
cord-280878-1kt51viz	487	7	Evidence	evidence	NN
cord-280878-1kt51viz	487	8	for	for	IN
cord-280878-1kt51viz	487	9	the	the	DT
cord-280878-1kt51viz	487	10	formation	formation	NN
cord-280878-1kt51viz	487	11	of	of	IN
cord-280878-1kt51viz	487	12	a	a	DT
cord-280878-1kt51viz	487	13	heptameric	heptameric	JJ
cord-280878-1kt51viz	487	14	ion	ion	NN
cord-280878-1kt51viz	487	15	channel	channel	NN
cord-280878-1kt51viz	487	16	complex	complex	NN
cord-280878-1kt51viz	487	17	by	by	IN
cord-280878-1kt51viz	487	18	the	the	DT
cord-280878-1kt51viz	487	19	hepatitis	hepatitis	NN
cord-280878-1kt51viz	487	20	C	C	NNP
cord-280878-1kt51viz	487	21	virus	virus	NN
cord-280878-1kt51viz	487	22	P7	p7	NN
cord-280878-1kt51viz	487	23	protein	protein	NN
cord-280878-1kt51viz	487	24	in	in	IN
cord-280878-1kt51viz	487	25	vitro	vitro	FW
cord-280878-1kt51viz	487	26	Identification	identification	NN
cord-280878-1kt51viz	487	27	of	of	IN
cord-280878-1kt51viz	487	28	a	a	DT
cord-280878-1kt51viz	487	29	protein	protein	NN
cord-280878-1kt51viz	487	30	encoded	encode	VBN
cord-280878-1kt51viz	487	31	by	by	IN
cord-280878-1kt51viz	487	32	the	the	DT
cord-280878-1kt51viz	487	33	vpu	vpu	NN
cord-280878-1kt51viz	487	34	gene	gene	NN
cord-280878-1kt51viz	487	35	of	of	IN
cord-280878-1kt51viz	487	36	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	487	37	Progress	Progress	NNP
cord-280878-1kt51viz	487	38	in	in	IN
cord-280878-1kt51viz	487	39	understanding	understanding	NN
cord-280878-1kt51viz	487	40	and	and	CC
cord-280878-1kt51viz	487	41	controlling	control	VBG
cord-280878-1kt51viz	487	42	respiratory	respiratory	JJ
cord-280878-1kt51viz	487	43	syncytial	syncytial	JJ
cord-280878-1kt51viz	487	44	virus	virus	NN
cord-280878-1kt51viz	487	45	:	:	:
cord-280878-1kt51viz	488	1	Still	still	RB
cord-280878-1kt51viz	488	2	crazy	crazy	JJ
cord-280878-1kt51viz	488	3	after	after	IN
cord-280878-1kt51viz	488	4	all	all	PDT
cord-280878-1kt51viz	488	5	these	these	DT
cord-280878-1kt51viz	488	6	years	year	NNS
cord-280878-1kt51viz	488	7	Membrane	membrane	NN
cord-280878-1kt51viz	488	8	orientation	orientation	NN
cord-280878-1kt51viz	488	9	and	and	CC
cord-280878-1kt51viz	488	10	oligomerization	oligomerization	NN
cord-280878-1kt51viz	488	11	of	of	IN
cord-280878-1kt51viz	488	12	the	the	DT
cord-280878-1kt51viz	488	13	small	small	JJ
cord-280878-1kt51viz	488	14	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	488	15	protein	protein	NN
cord-280878-1kt51viz	488	16	of	of	IN
cord-280878-1kt51viz	488	17	human	human	JJ
cord-280878-1kt51viz	488	18	respiratory	respiratory	JJ
cord-280878-1kt51viz	488	19	syncytial	syncytial	JJ
cord-280878-1kt51viz	488	20	virus	virus	NN
cord-280878-1kt51viz	488	21	NMR	NMR	NNP
cord-280878-1kt51viz	488	22	studies	study	NNS
cord-280878-1kt51viz	488	23	of	of	IN
cord-280878-1kt51viz	488	24	p7	p7	NN
cord-280878-1kt51viz	488	25	protein	protein	NN
cord-280878-1kt51viz	488	26	from	from	IN
cord-280878-1kt51viz	488	27	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	488	28	C	C	NNP
cord-280878-1kt51viz	488	29	virus	virus	NN
cord-280878-1kt51viz	488	30	Secondary	secondary	JJ
cord-280878-1kt51viz	488	31	structure	structure	NN
cord-280878-1kt51viz	488	32	,	,	,
cord-280878-1kt51viz	488	33	dynamics	dynamic	NNS
cord-280878-1kt51viz	488	34	,	,	,
cord-280878-1kt51viz	488	35	and	and	CC
cord-280878-1kt51viz	488	36	architecture	architecture	NN
cord-280878-1kt51viz	488	37	of	of	IN
cord-280878-1kt51viz	488	38	the	the	DT
cord-280878-1kt51viz	488	39	p7	p7	NN
cord-280878-1kt51viz	488	40	membrane	membrane	NN
cord-280878-1kt51viz	488	41	protein	protein	NN
cord-280878-1kt51viz	488	42	from	from	IN
cord-280878-1kt51viz	488	43	hepatitis	hepatitis	NN
cord-280878-1kt51viz	488	44	C	C	NNP
cord-280878-1kt51viz	488	45	virus	virus	NN
cord-280878-1kt51viz	488	46	by	by	IN
cord-280878-1kt51viz	488	47	NMR	NMR	NNP
cord-280878-1kt51viz	488	48	spectroscopy	spectroscopy	NN
cord-280878-1kt51viz	488	49	Comparative	Comparative	NNP
cord-280878-1kt51viz	488	50	NMR	NMR	NNP
cord-280878-1kt51viz	488	51	studies	study	NNS
cord-280878-1kt51viz	488	52	demonstrate	demonstrate	VBP
cord-280878-1kt51viz	488	53	profound	profound	JJ
cord-280878-1kt51viz	488	54	differences	difference	NNS
cord-280878-1kt51viz	488	55	between	between	IN
cord-280878-1kt51viz	488	56	two	two	CD
cord-280878-1kt51viz	488	57	viroporins	viroporin	NNS
cord-280878-1kt51viz	488	58	:	:	:
cord-280878-1kt51viz	488	59	p7	p7	NN
cord-280878-1kt51viz	488	60	of	of	IN
cord-280878-1kt51viz	488	61	HCV	HCV	NNP
cord-280878-1kt51viz	488	62	and	and	CC
cord-280878-1kt51viz	488	63	Vpu	Vpu	NNP
cord-280878-1kt51viz	488	64	of	of	IN
cord-280878-1kt51viz	488	65	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	488	66	Nuclear	Nuclear	NNP
cord-280878-1kt51viz	488	67	magnetic	magnetic	JJ
cord-280878-1kt51viz	488	68	resonance	resonance	NN
cord-280878-1kt51viz	488	69	structure	structure	NN
cord-280878-1kt51viz	488	70	revealed	reveal	VBD
cord-280878-1kt51viz	488	71	that	that	IN
cord-280878-1kt51viz	488	72	the	the	DT
cord-280878-1kt51viz	488	73	human	human	JJ
cord-280878-1kt51viz	488	74	polyomavirus	polyomavirus	NNP
cord-280878-1kt51viz	488	75	JC	JC	NNP
cord-280878-1kt51viz	488	76	virus	virus	NN
cord-280878-1kt51viz	488	77	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	488	78	contains	contain	VBZ
cord-280878-1kt51viz	488	79	an	an	DT
cord-280878-1kt51viz	488	80	alpha	alpha	NN
cord-280878-1kt51viz	488	81	-	-	HYPH
cord-280878-1kt51viz	488	82	helix	helix	NN
cord-280878-1kt51viz	488	83	encompassing	encompass	VBG
cord-280878-1kt51viz	488	84	the	the	DT
cord-280878-1kt51viz	488	85	Leu	Leu	NNP
cord-280878-1kt51viz	488	86	/	/	SYM
cord-280878-1kt51viz	488	87	Ile	Ile	NNP
cord-280878-1kt51viz	488	88	/	/	SYM
cord-280878-1kt51viz	488	89	Pherich	Pherich	NNP
cord-280878-1kt51viz	488	90	domain	domain	NN
cord-280878-1kt51viz	488	91	Infectious	infectious	JJ
cord-280878-1kt51viz	488	92	bronchitis	bronchitis	NN
cord-280878-1kt51viz	488	93	virus	virus	NN
cord-280878-1kt51viz	488	94	E	e	NN
cord-280878-1kt51viz	488	95	protein	protein	NN
cord-280878-1kt51viz	488	96	is	be	VBZ
cord-280878-1kt51viz	488	97	targeted	target	VBN
cord-280878-1kt51viz	488	98	to	to	IN
cord-280878-1kt51viz	488	99	the	the	DT
cord-280878-1kt51viz	488	100	Golgi	Golgi	NNP
cord-280878-1kt51viz	488	101	complex	complex	NN
cord-280878-1kt51viz	488	102	and	and	CC
cord-280878-1kt51viz	488	103	directs	direct	VBZ
cord-280878-1kt51viz	488	104	release	release	NN
cord-280878-1kt51viz	488	105	of	of	IN
cord-280878-1kt51viz	488	106	virus	virus	NN
cord-280878-1kt51viz	488	107	-	-	HYPH
cord-280878-1kt51viz	488	108	like	like	JJ
cord-280878-1kt51viz	488	109	particles	particle	NNS
cord-280878-1kt51viz	489	1	The	the	DT
cord-280878-1kt51viz	489	2	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	489	3	tails	tail	NNS
cord-280878-1kt51viz	489	4	of	of	IN
cord-280878-1kt51viz	489	5	infectious	infectious	JJ
cord-280878-1kt51viz	489	6	bronchitis	bronchitis	NN
cord-280878-1kt51viz	489	7	virus	virus	NN
cord-280878-1kt51viz	489	8	E	e	NN
cord-280878-1kt51viz	489	9	and	and	CC
cord-280878-1kt51viz	489	10	M	M	NNP
cord-280878-1kt51viz	489	11	proteins	protein	NNS
cord-280878-1kt51viz	489	12	mediate	mediate	VBP
cord-280878-1kt51viz	489	13	their	-PRON-	PRP$
cord-280878-1kt51viz	489	14	interaction	interaction	NN
cord-280878-1kt51viz	489	15	M2	m2	NN
cord-280878-1kt51viz	489	16	protein	protein	NN
cord-280878-1kt51viz	489	17	from	from	IN
cord-280878-1kt51viz	489	18	influenza	influenza	NN
cord-280878-1kt51viz	489	19	A	a	NN
cord-280878-1kt51viz	489	20	:	:	:
cord-280878-1kt51viz	489	21	From	from	IN
cord-280878-1kt51viz	489	22	multiple	multiple	JJ
cord-280878-1kt51viz	489	23	structures	structure	NNS
cord-280878-1kt51viz	489	24	to	to	IN
cord-280878-1kt51viz	489	25	biophysical	biophysical	JJ
cord-280878-1kt51viz	489	26	and	and	CC
cord-280878-1kt51viz	489	27	functional	functional	JJ
cord-280878-1kt51viz	489	28	insights	insight	NNS
cord-280878-1kt51viz	489	29	.	.	.
cord-280878-1kt51viz	490	1	Current	current	JJ
cord-280878-1kt51viz	490	2	Opinion	opinion	NN
cord-280878-1kt51viz	490	3	in	in	IN
cord-280878-1kt51viz	490	4	Virology	Virology	NNP
cord-280878-1kt51viz	490	5	Influence	influence	NN
cord-280878-1kt51viz	490	6	of	of	IN
cord-280878-1kt51viz	490	7	solubilizing	solubilize	VBG
cord-280878-1kt51viz	490	8	environments	environment	NNS
cord-280878-1kt51viz	490	9	on	on	IN
cord-280878-1kt51viz	490	10	membrane	membrane	NN
cord-280878-1kt51viz	490	11	protein	protein	NN
cord-280878-1kt51viz	490	12	structures	structure	NNS
cord-280878-1kt51viz	490	13	Structural	structural	JJ
cord-280878-1kt51viz	490	14	mechanism	mechanism	NN
cord-280878-1kt51viz	490	15	of	of	IN
cord-280878-1kt51viz	490	16	C	c	NN
cord-280878-1kt51viz	490	17	-	-	HYPH
cord-280878-1kt51viz	490	18	type	type	NN
cord-280878-1kt51viz	490	19	inactivation	inactivation	NN
cord-280878-1kt51viz	490	20	in	in	IN
cord-280878-1kt51viz	490	21	K+	K+	NNP
cord-280878-1kt51viz	490	22	channels	channel	NNS
cord-280878-1kt51viz	490	23	Antiviral	antiviral	JJ
cord-280878-1kt51viz	490	24	activity	activity	NN
cord-280878-1kt51viz	490	25	of	of	IN
cord-280878-1kt51viz	490	26	1-adamantanamine	1-adamantanamine	CD
cord-280878-1kt51viz	490	27	(	(	-LRB-
cord-280878-1kt51viz	490	28	amantadine	amantadine	NNP
cord-280878-1kt51viz	490	29	)	)	-RRB-
cord-280878-1kt51viz	490	30	Antiviral	antiviral	JJ
cord-280878-1kt51viz	490	31	agents	agent	NNS
cord-280878-1kt51viz	490	32	active	active	JJ
cord-280878-1kt51viz	490	33	against	against	IN
cord-280878-1kt51viz	490	34	influenza	influenza	NN
cord-280878-1kt51viz	490	35	A	a	NN
cord-280878-1kt51viz	490	36	viruses	virus	NNS
cord-280878-1kt51viz	490	37	Determinants	determinant	NNS
cord-280878-1kt51viz	490	38	for	for	IN
cord-280878-1kt51viz	490	39	membrane	membrane	NNP
cord-280878-1kt51viz	490	40	association	association	NNP
cord-280878-1kt51viz	490	41	and	and	CC
cord-280878-1kt51viz	490	42	permeabilization	permeabilization	NN
cord-280878-1kt51viz	490	43	of	of	IN
cord-280878-1kt51viz	490	44	the	the	DT
cord-280878-1kt51viz	490	45	coxsackievirus	coxsackievirus	NNP
cord-280878-1kt51viz	490	46	2B	2B	NNP
cord-280878-1kt51viz	490	47	protein	protein	NNP
cord-280878-1kt51viz	490	48	and	and	CC
cord-280878-1kt51viz	490	49	the	the	DT
cord-280878-1kt51viz	490	50	identification	identification	NN
cord-280878-1kt51viz	490	51	of	of	IN
cord-280878-1kt51viz	490	52	the	the	DT
cord-280878-1kt51viz	490	53	Golgi	Golgi	NNP
cord-280878-1kt51viz	490	54	complex	complex	NN
cord-280878-1kt51viz	490	55	as	as	IN
cord-280878-1kt51viz	490	56	the	the	DT
cord-280878-1kt51viz	490	57	target	target	NN
cord-280878-1kt51viz	490	58	organelle	organelle	NN
cord-280878-1kt51viz	490	59	Severe	severe	JJ
cord-280878-1kt51viz	490	60	acute	acute	JJ
cord-280878-1kt51viz	490	61	respiratory	respiratory	JJ
cord-280878-1kt51viz	490	62	syndrome	syndrome	NN
cord-280878-1kt51viz	490	63	coronavirus	coronavirus	NN
cord-280878-1kt51viz	490	64	envelope	envelope	NN
cord-280878-1kt51viz	490	65	protein	protein	NN
cord-280878-1kt51viz	490	66	regulates	regulate	VBZ
cord-280878-1kt51viz	490	67	cell	cell	NN
cord-280878-1kt51viz	490	68	stress	stress	NN
cord-280878-1kt51viz	490	69	response	response	NN
cord-280878-1kt51viz	490	70	and	and	CC
cord-280878-1kt51viz	490	71	apoptosis	apoptosis	NN
cord-280878-1kt51viz	490	72	Inhibition	inhibition	NN
cord-280878-1kt51viz	490	73	of	of	IN
cord-280878-1kt51viz	490	74	NF	NF	NNP
cord-280878-1kt51viz	490	75	-	-	HYPH
cord-280878-1kt51viz	490	76	κB	κB	NNP
cord-280878-1kt51viz	490	77	-	-	HYPH
cord-280878-1kt51viz	490	78	mediated	mediate	VBN
cord-280878-1kt51viz	490	79	inflammation	inflammation	NN
cord-280878-1kt51viz	490	80	in	in	IN
cord-280878-1kt51viz	490	81	severe	severe	JJ
cord-280878-1kt51viz	490	82	acute	acute	JJ
cord-280878-1kt51viz	490	83	respiratory	respiratory	JJ
cord-280878-1kt51viz	490	84	syndrome	syndrome	NN
cord-280878-1kt51viz	490	85	coronavirus	coronavirus	NN
cord-280878-1kt51viz	490	86	-	-	HYPH
cord-280878-1kt51viz	490	87	infected	infect	VBN
cord-280878-1kt51viz	490	88	mice	mice	NN
cord-280878-1kt51viz	490	89	increases	increase	VBZ
cord-280878-1kt51viz	490	90	survival	survival	NN
cord-280878-1kt51viz	490	91	Surveillance	surveillance	NN
cord-280878-1kt51viz	490	92	of	of	IN
cord-280878-1kt51viz	490	93	resistance	resistance	NN
cord-280878-1kt51viz	490	94	to	to	IN
cord-280878-1kt51viz	490	95	adamantanes	adamantane	NNS
cord-280878-1kt51viz	490	96	among	among	IN
cord-280878-1kt51viz	490	97	influenza	influenza	NN
cord-280878-1kt51viz	490	98	A(H3N2	A(H3N2	NNP
cord-280878-1kt51viz	490	99	)	)	-RRB-
cord-280878-1kt51viz	490	100	and	and	CC
cord-280878-1kt51viz	490	101	A(H1N1	A(H1N1	NNP
cord-280878-1kt51viz	490	102	)	)	-RRB-
cord-280878-1kt51viz	490	103	viruses	virus	NNS
cord-280878-1kt51viz	490	104	isolated	isolate	VBN
cord-280878-1kt51viz	490	105	worldwide	worldwide	JJ
cord-280878-1kt51viz	490	106	Full	full	JJ
cord-280878-1kt51viz	490	107	-	-	HYPH
cord-280878-1kt51viz	490	108	length	length	NN
cord-280878-1kt51viz	490	109	Vpu	Vpu	NNP
cord-280878-1kt51viz	490	110	and	and	CC
cord-280878-1kt51viz	490	111	human	human	JJ
cord-280878-1kt51viz	490	112	CD4(372	CD4(372	NNP
cord-280878-1kt51viz	490	113	-	-	HYPH
cord-280878-1kt51viz	490	114	433	433	CD
cord-280878-1kt51viz	490	115	)	)	-RRB-
cord-280878-1kt51viz	490	116	in	in	IN
cord-280878-1kt51viz	490	117	phospholipid	phospholipid	NN
cord-280878-1kt51viz	490	118	bilayers	bilayer	NNS
cord-280878-1kt51viz	490	119	as	as	IN
cord-280878-1kt51viz	490	120	seen	see	VBN
cord-280878-1kt51viz	490	121	by	by	IN
cord-280878-1kt51viz	490	122	magic	magic	JJ
cord-280878-1kt51viz	490	123	angle	angle	NN
cord-280878-1kt51viz	490	124	spinning	spin	VBG
cord-280878-1kt51viz	490	125	NMR	NMR	NNP
cord-280878-1kt51viz	490	126	Small	small	JJ
cord-280878-1kt51viz	490	127	molecules	molecule	NNS
cord-280878-1kt51viz	490	128	VP-14637	vp-14637	VBP
cord-280878-1kt51viz	490	129	and	and	CC
cord-280878-1kt51viz	490	130	JNJ-2408068	JNJ-2408068	NNP
cord-280878-1kt51viz	490	131	inhibit	inhibit	VBP
cord-280878-1kt51viz	490	132	respiratory	respiratory	JJ
cord-280878-1kt51viz	490	133	syncytial	syncytial	JJ
cord-280878-1kt51viz	490	134	virus	virus	NN
cord-280878-1kt51viz	490	135	fusion	fusion	NN
cord-280878-1kt51viz	490	136	by	by	IN
cord-280878-1kt51viz	490	137	similar	similar	JJ
cord-280878-1kt51viz	490	138	mechanisms	mechanism	NNS
cord-280878-1kt51viz	491	1	Respiratory	respiratory	JJ
cord-280878-1kt51viz	491	2	syncytial	syncytial	JJ
cord-280878-1kt51viz	491	3	virus	virus	NN
cord-280878-1kt51viz	491	4	is	be	VBZ
cord-280878-1kt51viz	491	5	an	an	DT
cord-280878-1kt51viz	491	6	important	important	JJ
cord-280878-1kt51viz	491	7	cause	cause	NN
cord-280878-1kt51viz	491	8	of	of	IN
cord-280878-1kt51viz	491	9	community	community	NN
cord-280878-1kt51viz	491	10	-	-	HYPH
cord-280878-1kt51viz	491	11	acquired	acquire	VBN
cord-280878-1kt51viz	491	12	lower	low	JJR
cord-280878-1kt51viz	491	13	respiratory	respiratory	JJ
cord-280878-1kt51viz	491	14	infection	infection	NN
cord-280878-1kt51viz	491	15	among	among	IN
cord-280878-1kt51viz	491	16	hospitalized	hospitalize	VBN
cord-280878-1kt51viz	491	17	adults	adult	NNS
cord-280878-1kt51viz	492	1	The	the	DT
cord-280878-1kt51viz	492	2	structure	structure	NN
cord-280878-1kt51viz	492	3	of	of	IN
cord-280878-1kt51viz	492	4	the	the	DT
cord-280878-1kt51viz	492	5	potassium	potassium	NN
cord-280878-1kt51viz	492	6	channel	channel	NN
cord-280878-1kt51viz	492	7	:	:	:
cord-280878-1kt51viz	493	1	Molecular	molecular	JJ
cord-280878-1kt51viz	493	2	basis	basis	NN
cord-280878-1kt51viz	493	3	of	of	IN
cord-280878-1kt51viz	493	4	K	k	NN
cord-280878-1kt51viz	493	5	+	+	CC
cord-280878-1kt51viz	493	6	conduction	conduction	NN
cord-280878-1kt51viz	493	7	and	and	CC
cord-280878-1kt51viz	493	8	selectivity	selectivity	NN
cord-280878-1kt51viz	493	9	Comparative	comparative	JJ
cord-280878-1kt51viz	493	10	rates	rate	NNS
cord-280878-1kt51viz	493	11	of	of	IN
cord-280878-1kt51viz	493	12	spontaneous	spontaneous	JJ
cord-280878-1kt51viz	493	13	mutation	mutation	NN
cord-280878-1kt51viz	494	1	Recent	recent	JJ
cord-280878-1kt51viz	494	2	progress	progress	NN
cord-280878-1kt51viz	494	3	in	in	IN
cord-280878-1kt51viz	494	4	structure	structure	NN
cord-280878-1kt51viz	494	5	-	-	HYPH
cord-280878-1kt51viz	494	6	based	base	VBN
cord-280878-1kt51viz	494	7	anti	anti	JJ
cord-280878-1kt51viz	494	8	-	-	JJ
cord-280878-1kt51viz	494	9	influenza	influenza	JJ
cord-280878-1kt51viz	494	10	drug	drug	NN
cord-280878-1kt51viz	494	11	design	design	NN
cord-280878-1kt51viz	495	1	The	the	DT
cord-280878-1kt51viz	495	2	transmembrane	transmembrane	NN
cord-280878-1kt51viz	495	3	domain	domain	NN
cord-280878-1kt51viz	495	4	of	of	IN
cord-280878-1kt51viz	495	5	influenza	influenza	NN
cord-280878-1kt51viz	495	6	A	a	DT
cord-280878-1kt51viz	495	7	M2	M2	NNP
cord-280878-1kt51viz	495	8	protein	protein	NN
cord-280878-1kt51viz	495	9	forms	form	VBZ
cord-280878-1kt51viz	495	10	amantadine	amantadine	NN
cord-280878-1kt51viz	495	11	-	-	HYPH
cord-280878-1kt51viz	495	12	sensitive	sensitive	JJ
cord-280878-1kt51viz	495	13	proton	proton	NN
cord-280878-1kt51viz	495	14	channels	channel	NNS
cord-280878-1kt51viz	495	15	in	in	IN
cord-280878-1kt51viz	495	16	planar	planar	JJ
cord-280878-1kt51viz	495	17	lipid	lipid	NN
cord-280878-1kt51viz	495	18	bilayers	bilayer	NNS
cord-280878-1kt51viz	495	19	Role	role	NN
cord-280878-1kt51viz	495	20	of	of	IN
cord-280878-1kt51viz	495	21	agnogene	agnogene	JJ
cord-280878-1kt51viz	495	22	deletion	deletion	NN
cord-280878-1kt51viz	495	23	and	and	CC
cord-280878-1kt51viz	495	24	archetype	archetype	NN
cord-280878-1kt51viz	495	25	-	-	HYPH
cord-280878-1kt51viz	495	26	like	like	JJ
cord-280878-1kt51viz	495	27	regulatory	regulatory	JJ
cord-280878-1kt51viz	495	28	region	region	NN
cord-280878-1kt51viz	495	29	in	in	IN
cord-280878-1kt51viz	495	30	a	a	DT
cord-280878-1kt51viz	495	31	JCV	JCV	NNP
cord-280878-1kt51viz	495	32	strain	strain	NN
cord-280878-1kt51viz	495	33	isolated	isolate	VBN
cord-280878-1kt51viz	495	34	from	from	IN
cord-280878-1kt51viz	495	35	the	the	DT
cord-280878-1kt51viz	495	36	brain	brain	NN
cord-280878-1kt51viz	495	37	of	of	IN
cord-280878-1kt51viz	495	38	a	a	DT
cord-280878-1kt51viz	495	39	patient	patient	NN
cord-280878-1kt51viz	495	40	with	with	IN
cord-280878-1kt51viz	495	41	JCV	JCV	NNP
cord-280878-1kt51viz	495	42	Encephalopathy	Encephalopathy	NNP
cord-280878-1kt51viz	495	43	(	(	-LRB-
cord-280878-1kt51viz	495	44	JCVE	JCVE	NNP
cord-280878-1kt51viz	495	45	)	)	-RRB-
cord-280878-1kt51viz	496	1	Agnogene	agnogene	JJ
cord-280878-1kt51viz	496	2	deletion	deletion	NN
cord-280878-1kt51viz	496	3	in	in	IN
cord-280878-1kt51viz	496	4	a	a	DT
cord-280878-1kt51viz	496	5	novel	novel	JJ
cord-280878-1kt51viz	496	6	pathogenic	pathogenic	JJ
cord-280878-1kt51viz	496	7	JC	JC	NNP
cord-280878-1kt51viz	496	8	virus	virus	NN
cord-280878-1kt51viz	496	9	isolate	isolate	VB
cord-280878-1kt51viz	496	10	impairs	impair	VBZ
cord-280878-1kt51viz	496	11	VP1	vp1	NN
cord-280878-1kt51viz	496	12	expression	expression	NN
cord-280878-1kt51viz	496	13	and	and	CC
cord-280878-1kt51viz	496	14	virion	virion	NN
cord-280878-1kt51viz	496	15	production	production	NN
cord-280878-1kt51viz	496	16	Virus	Virus	NNP
cord-280878-1kt51viz	496	17	taxonomy	taxonomy	NN
cord-280878-1kt51viz	496	18	.	.	.
cord-280878-1kt51viz	497	1	Classification	classification	NN
cord-280878-1kt51viz	497	2	and	and	CC
cord-280878-1kt51viz	497	3	nomenclature	nomenclature	NN
cord-280878-1kt51viz	497	4	of	of	IN
cord-280878-1kt51viz	497	5	viruses	virus	NNS
cord-280878-1kt51viz	498	1	Recombinant	recombinant	JJ
cord-280878-1kt51viz	498	2	live	live	JJ
cord-280878-1kt51viz	498	3	vaccines	vaccine	NNS
cord-280878-1kt51viz	498	4	to	to	TO
cord-280878-1kt51viz	498	5	protect	protect	VB
cord-280878-1kt51viz	498	6	against	against	IN
cord-280878-1kt51viz	498	7	the	the	DT
cord-280878-1kt51viz	498	8	severe	severe	JJ
cord-280878-1kt51viz	498	9	acute	acute	JJ
cord-280878-1kt51viz	498	10	respiratory	respiratory	JJ
cord-280878-1kt51viz	498	11	syndrome	syndrome	NN
cord-280878-1kt51viz	498	12	coronavirus	coronavirus	NN
cord-280878-1kt51viz	499	1	The	the	DT
cord-280878-1kt51viz	499	2	Vpu	Vpu	NNP
cord-280878-1kt51viz	499	3	protein	protein	NN
cord-280878-1kt51viz	499	4	of	of	IN
cord-280878-1kt51viz	499	5	human	human	JJ
cord-280878-1kt51viz	499	6	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	499	7	virus	virus	NN
cord-280878-1kt51viz	499	8	type	type	NN
cord-280878-1kt51viz	499	9	1	1	CD
cord-280878-1kt51viz	499	10	forms	form	NNS
cord-280878-1kt51viz	499	11	cation	cation	NN
cord-280878-1kt51viz	499	12	-	-	HYPH
cord-280878-1kt51viz	499	13	selective	selective	JJ
cord-280878-1kt51viz	499	14	ion	ion	NN
cord-280878-1kt51viz	499	15	channels	channel	NNS
cord-280878-1kt51viz	500	1	Antiviral	antiviral	JJ
cord-280878-1kt51viz	500	2	agents	agent	NNS
cord-280878-1kt51viz	500	3	for	for	IN
cord-280878-1kt51viz	500	4	the	the	DT
cord-280878-1kt51viz	500	5	treatment	treatment	NN
cord-280878-1kt51viz	500	6	and	and	CC
cord-280878-1kt51viz	500	7	chemoprophylaxis	chemoprophylaxis	NN
cord-280878-1kt51viz	500	8	of	of	IN
cord-280878-1kt51viz	500	9	influenza	influenza	NN
cord-280878-1kt51viz	500	10	-	-	:
cord-280878-1kt51viz	500	11	Recommendations	Recommendations	NNPS
cord-280878-1kt51viz	500	12	of	of	IN
cord-280878-1kt51viz	500	13	the	the	DT
cord-280878-1kt51viz	500	14	Advisory	Advisory	NNP
cord-280878-1kt51viz	500	15	Committee	Committee	NNP
cord-280878-1kt51viz	500	16	on	on	IN
cord-280878-1kt51viz	500	17	Immunization	Immunization	NNP
cord-280878-1kt51viz	500	18	Practices	Practices	NNPS
cord-280878-1kt51viz	500	19	(	(	-LRB-
cord-280878-1kt51viz	500	20	ACIP	ACIP	NNP
cord-280878-1kt51viz	500	21	)	)	-RRB-
cord-280878-1kt51viz	500	22	Viral	viral	JJ
cord-280878-1kt51viz	500	23	channel	channel	NN
cord-280878-1kt51viz	500	24	proteins	protein	NNS
cord-280878-1kt51viz	500	25	in	in	IN
cord-280878-1kt51viz	500	26	intracellular	intracellular	JJ
cord-280878-1kt51viz	500	27	protein	protein	NN
cord-280878-1kt51viz	500	28	-	-	HYPH
cord-280878-1kt51viz	500	29	protein	protein	NN
cord-280878-1kt51viz	500	30	communication	communication	NN
cord-280878-1kt51viz	500	31	:	:	:
cord-280878-1kt51viz	500	32	Vpu	Vpu	NNP
cord-280878-1kt51viz	500	33	of	of	IN
cord-280878-1kt51viz	500	34	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	500	35	,	,	,
cord-280878-1kt51viz	500	36	E5	E5	NNP
cord-280878-1kt51viz	500	37	of	of	IN
cord-280878-1kt51viz	500	38	HPV16	hpv16	NN
cord-280878-1kt51viz	500	39	and	and	CC
cord-280878-1kt51viz	500	40	p7	p7	NN
cord-280878-1kt51viz	500	41	of	of	IN
cord-280878-1kt51viz	500	42	HCV	HCV	NNP
cord-280878-1kt51viz	500	43	Mechanism	Mechanism	NNP
cord-280878-1kt51viz	500	44	of	of	IN
cord-280878-1kt51viz	500	45	function	function	NN
cord-280878-1kt51viz	500	46	of	of	IN
cord-280878-1kt51viz	500	47	viral	viral	JJ
cord-280878-1kt51viz	500	48	channel	channel	NN
cord-280878-1kt51viz	500	49	proteins	protein	NNS
cord-280878-1kt51viz	500	50	and	and	CC
cord-280878-1kt51viz	500	51	implications	implication	NNS
cord-280878-1kt51viz	500	52	for	for	IN
cord-280878-1kt51viz	500	53	drug	drug	NN
cord-280878-1kt51viz	500	54	development	development	NN
cord-280878-1kt51viz	500	55	Structure	Structure	NNP
cord-280878-1kt51viz	500	56	-	-	HYPH
cord-280878-1kt51viz	500	57	guided	guide	VBN
cord-280878-1kt51viz	500	58	design	design	NN
cord-280878-1kt51viz	500	59	affirms	affirm	VBZ
cord-280878-1kt51viz	500	60	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	500	61	of	of	IN
cord-280878-1kt51viz	500	62	hepatitis	hepatitis	NN
cord-280878-1kt51viz	500	63	C	C	NNP
cord-280878-1kt51viz	500	64	virus	virus	NN
cord-280878-1kt51viz	500	65	p7	p7	RB
cord-280878-1kt51viz	500	66	as	as	IN
cord-280878-1kt51viz	500	67	a	a	DT
cord-280878-1kt51viz	500	68	viable	viable	JJ
cord-280878-1kt51viz	500	69	class	class	NN
cord-280878-1kt51viz	500	70	of	of	IN
cord-280878-1kt51viz	500	71	antivirals	antiviral	NNS
cord-280878-1kt51viz	500	72	targeting	target	VBG
cord-280878-1kt51viz	500	73	virion	virion	NN
cord-280878-1kt51viz	500	74	release	release	NN
cord-280878-1kt51viz	501	1	Resistance	resistance	NN
cord-280878-1kt51viz	501	2	mutations	mutation	NNS
cord-280878-1kt51viz	501	3	define	define	VBP
cord-280878-1kt51viz	501	4	specific	specific	JJ
cord-280878-1kt51viz	501	5	antiviral	antiviral	JJ
cord-280878-1kt51viz	501	6	effects	effect	NNS
cord-280878-1kt51viz	501	7	for	for	IN
cord-280878-1kt51viz	501	8	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	501	9	of	of	IN
cord-280878-1kt51viz	501	10	the	the	DT
cord-280878-1kt51viz	501	11	hepatitis	hepatitis	NN
cord-280878-1kt51viz	501	12	C	C	NNP
cord-280878-1kt51viz	501	13	virus	virus	NN
cord-280878-1kt51viz	501	14	p7	p7	NN
cord-280878-1kt51viz	501	15	ion	ion	NN
cord-280878-1kt51viz	501	16	channel	channel	NN
cord-280878-1kt51viz	501	17	Function	function	NN
cord-280878-1kt51viz	501	18	of	of	IN
cord-280878-1kt51viz	501	19	the	the	DT
cord-280878-1kt51viz	501	20	respiratory	respiratory	JJ
cord-280878-1kt51viz	501	21	syncytial	syncytial	JJ
cord-280878-1kt51viz	501	22	virus	virus	NN
cord-280878-1kt51viz	501	23	small	small	JJ
cord-280878-1kt51viz	501	24	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	501	25	protein	protein	NN
cord-280878-1kt51viz	501	26	Large	large	JJ
cord-280878-1kt51viz	501	27	-	-	HYPH
cord-280878-1kt51viz	501	28	scale	scale	NN
cord-280878-1kt51viz	501	29	sequence	sequence	NN
cord-280878-1kt51viz	501	30	analysis	analysis	NN
cord-280878-1kt51viz	501	31	of	of	IN
cord-280878-1kt51viz	501	32	M	M	NNP
cord-280878-1kt51viz	501	33	gene	gene	NN
cord-280878-1kt51viz	501	34	of	of	IN
cord-280878-1kt51viz	501	35	influenza	influenza	NN
cord-280878-1kt51viz	501	36	A	a	DT
cord-280878-1kt51viz	501	37	viruses	virus	NNS
cord-280878-1kt51viz	501	38	from	from	IN
cord-280878-1kt51viz	501	39	different	different	JJ
cord-280878-1kt51viz	501	40	species	specie	NNS
cord-280878-1kt51viz	501	41	:	:	:
cord-280878-1kt51viz	501	42	Mechanisms	mechanism	NNS
cord-280878-1kt51viz	501	43	for	for	IN
cord-280878-1kt51viz	501	44	emergence	emergence	NN
cord-280878-1kt51viz	501	45	and	and	CC
cord-280878-1kt51viz	501	46	spread	spread	NN
cord-280878-1kt51viz	501	47	of	of	IN
cord-280878-1kt51viz	501	48	amantadine	amantadine	NN
cord-280878-1kt51viz	501	49	resistance	resistance	NN
cord-280878-1kt51viz	501	50	Site	site	NN
cord-280878-1kt51viz	501	51	-	-	HYPH
cord-280878-1kt51viz	501	52	directed	direct	VBN
cord-280878-1kt51viz	501	53	mutations	mutation	NNS
cord-280878-1kt51viz	501	54	in	in	IN
cord-280878-1kt51viz	501	55	the	the	DT
cord-280878-1kt51viz	501	56	Sindbis	Sindbis	NNP
cord-280878-1kt51viz	501	57	virus	virus	NN
cord-280878-1kt51viz	502	1	6	6	CD
cord-280878-1kt51viz	502	2	K	k	NN
cord-280878-1kt51viz	502	3	protein	protein	NN
cord-280878-1kt51viz	502	4	reveal	reveal	VBP
cord-280878-1kt51viz	502	5	sites	site	NNS
cord-280878-1kt51viz	502	6	for	for	IN
cord-280878-1kt51viz	502	7	fatty	fatty	JJ
cord-280878-1kt51viz	502	8	acylation	acylation	NN
cord-280878-1kt51viz	502	9	and	and	CC
cord-280878-1kt51viz	502	10	the	the	DT
cord-280878-1kt51viz	502	11	underacylated	underacylated	JJ
cord-280878-1kt51viz	502	12	protein	protein	NN
cord-280878-1kt51viz	502	13	affects	affect	VBZ
cord-280878-1kt51viz	502	14	virus	virus	NN
cord-280878-1kt51viz	502	15	release	release	NN
cord-280878-1kt51viz	502	16	and	and	CC
cord-280878-1kt51viz	502	17	virion	virion	NN
cord-280878-1kt51viz	502	18	structure	structure	NN
cord-280878-1kt51viz	502	19	Structure	Structure	NNP
cord-280878-1kt51viz	502	20	and	and	CC
cord-280878-1kt51viz	502	21	ion	ion	NN
cord-280878-1kt51viz	502	22	channel	channel	NN
cord-280878-1kt51viz	502	23	activity	activity	NN
cord-280878-1kt51viz	502	24	of	of	IN
cord-280878-1kt51viz	502	25	the	the	DT
cord-280878-1kt51viz	502	26	human	human	JJ
cord-280878-1kt51viz	502	27	respiratory	respiratory	JJ
cord-280878-1kt51viz	502	28	syncytial	syncytial	JJ
cord-280878-1kt51viz	502	29	virus	virus	NN
cord-280878-1kt51viz	502	30	(	(	-LRB-
cord-280878-1kt51viz	502	31	hRSV	hRSV	NNP
cord-280878-1kt51viz	502	32	)	)	-RRB-
cord-280878-1kt51viz	502	33	small	small	JJ
cord-280878-1kt51viz	502	34	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	502	35	protein	protein	NN
cord-280878-1kt51viz	502	36	transmembrane	transmembrane	NN
cord-280878-1kt51viz	502	37	domain	domain	NN
cord-280878-1kt51viz	502	38	Two	two	CD
cord-280878-1kt51viz	502	39	different	different	JJ
cord-280878-1kt51viz	502	40	conformations	conformation	NNS
cord-280878-1kt51viz	502	41	in	in	IN
cord-280878-1kt51viz	502	42	hepatitis	hepatitis	NN
cord-280878-1kt51viz	502	43	C	C	NNP
cord-280878-1kt51viz	502	44	virus	virus	NN
cord-280878-1kt51viz	502	45	p7	p7	NN
cord-280878-1kt51viz	502	46	protein	protein	NN
cord-280878-1kt51viz	502	47	account	account	VBP
cord-280878-1kt51viz	502	48	for	for	IN
cord-280878-1kt51viz	502	49	proton	proton	NN
cord-280878-1kt51viz	502	50	transport	transport	NN
cord-280878-1kt51viz	502	51	and	and	CC
cord-280878-1kt51viz	502	52	dye	dye	NN
cord-280878-1kt51viz	502	53	release	release	NN
cord-280878-1kt51viz	503	1	The	the	DT
cord-280878-1kt51viz	503	2	small	small	JJ
cord-280878-1kt51viz	503	3	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	503	4	protein	protein	NN
cord-280878-1kt51viz	503	5	of	of	IN
cord-280878-1kt51viz	503	6	the	the	DT
cord-280878-1kt51viz	503	7	human	human	JJ
cord-280878-1kt51viz	503	8	respiratory	respiratory	JJ
cord-280878-1kt51viz	503	9	syncytial	syncytial	JJ
cord-280878-1kt51viz	503	10	virus	virus	NN
cord-280878-1kt51viz	503	11	forms	form	NNS
cord-280878-1kt51viz	503	12	pentameric	pentameric	NN
cord-280878-1kt51viz	503	13	ion	ion	NN
cord-280878-1kt51viz	503	14	channels	channel	NNS
cord-280878-1kt51viz	503	15	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	503	16	C	C	NNP
cord-280878-1kt51viz	503	17	virus	virus	NN
cord-280878-1kt51viz	503	18	p7	p7	RB
cord-280878-1kt51viz	503	19	is	be	VBZ
cord-280878-1kt51viz	503	20	critical	critical	JJ
cord-280878-1kt51viz	503	21	for	for	IN
cord-280878-1kt51viz	503	22	capsid	capsid	NN
cord-280878-1kt51viz	503	23	assembly	assembly	NN
cord-280878-1kt51viz	503	24	and	and	CC
cord-280878-1kt51viz	503	25	envelopment	envelopment	NN
cord-280878-1kt51viz	503	26	Agnoprotein	Agnoprotein	NNP
cord-280878-1kt51viz	503	27	of	of	IN
cord-280878-1kt51viz	503	28	polyomavirus	polyomavirus	NNP
cord-280878-1kt51viz	503	29	BK	BK	NNP
cord-280878-1kt51viz	503	30	interacts	interact	VBZ
cord-280878-1kt51viz	503	31	with	with	IN
cord-280878-1kt51viz	503	32	proliferating	proliferate	VBG
cord-280878-1kt51viz	503	33	cell	cell	NN
cord-280878-1kt51viz	503	34	nuclear	nuclear	JJ
cord-280878-1kt51viz	503	35	antigen	antigen	NN
cord-280878-1kt51viz	503	36	and	and	CC
cord-280878-1kt51viz	503	37	inhibits	inhibit	VBZ
cord-280878-1kt51viz	503	38	DNA	dna	NN
cord-280878-1kt51viz	503	39	replication	replication	NN
cord-280878-1kt51viz	503	40	Agnoprotein	Agnoprotein	NNP
cord-280878-1kt51viz	503	41	of	of	IN
cord-280878-1kt51viz	503	42	mammalian	mammalian	JJ
cord-280878-1kt51viz	503	43	polyomaviruses	polyomaviruse	NNS
cord-280878-1kt51viz	503	44	Development	Development	NNP
cord-280878-1kt51viz	503	45	and	and	CC
cord-280878-1kt51viz	503	46	validation	validation	NN
cord-280878-1kt51viz	503	47	of	of	IN
cord-280878-1kt51viz	503	48	a	a	DT
cord-280878-1kt51viz	503	49	high	high	JJ
cord-280878-1kt51viz	503	50	-	-	HYPH
cord-280878-1kt51viz	503	51	throughput	throughput	NN
cord-280878-1kt51viz	503	52	screening	screening	NN
cord-280878-1kt51viz	503	53	assay	assay	NN
cord-280878-1kt51viz	503	54	for	for	IN
cord-280878-1kt51viz	503	55	the	the	DT
cord-280878-1kt51viz	503	56	hepatitis	hepatitis	NN
cord-280878-1kt51viz	503	57	C	C	NNP
cord-280878-1kt51viz	503	58	virus	virus	NN
cord-280878-1kt51viz	503	59	p7	p7	RB
cord-280878-1kt51viz	503	60	viroporin	viroporin	NNP
cord-280878-1kt51viz	503	61	TGEV	TGEV	NNP
cord-280878-1kt51viz	503	62	corona	corona	NN
cord-280878-1kt51viz	503	63	virus	virus	NN
cord-280878-1kt51viz	503	64	ORF4	ORF4	NNP
cord-280878-1kt51viz	503	65	encodes	encode	VBZ
cord-280878-1kt51viz	503	66	a	a	DT
cord-280878-1kt51viz	503	67	membrane	membrane	NN
cord-280878-1kt51viz	503	68	protein	protein	NN
cord-280878-1kt51viz	503	69	that	that	WDT
cord-280878-1kt51viz	503	70	is	be	VBZ
cord-280878-1kt51viz	503	71	incorporated	incorporate	VBN
cord-280878-1kt51viz	503	72	into	into	IN
cord-280878-1kt51viz	503	73	virions	virion	NNS
cord-280878-1kt51viz	503	74	Development	Development	NNP
cord-280878-1kt51viz	503	75	and	and	CC
cord-280878-1kt51viz	503	76	application	application	NN
cord-280878-1kt51viz	503	77	of	of	IN
cord-280878-1kt51viz	503	78	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	503	79	C	C	NNP
cord-280878-1kt51viz	503	80	reporter	reporter	NN
cord-280878-1kt51viz	503	81	viruses	virus	NNS
cord-280878-1kt51viz	503	82	with	with	IN
cord-280878-1kt51viz	503	83	genotype	genotype	NN
cord-280878-1kt51viz	503	84	1	1	CD
cord-280878-1kt51viz	503	85	to	to	IN
cord-280878-1kt51viz	503	86	7	7	CD
cord-280878-1kt51viz	503	87	core	core	NN
cord-280878-1kt51viz	503	88	-	-	HYPH
cord-280878-1kt51viz	503	89	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	503	90	protein	protein	NN
cord-280878-1kt51viz	503	91	2	2	CD
cord-280878-1kt51viz	503	92	(	(	-LRB-
cord-280878-1kt51viz	503	93	NS2	NS2	NNP
cord-280878-1kt51viz	503	94	)	)	-RRB-
cord-280878-1kt51viz	503	95	expressing	express	VBG
cord-280878-1kt51viz	503	96	fluorescent	fluorescent	NN
cord-280878-1kt51viz	503	97	proteins	protein	NNS
cord-280878-1kt51viz	503	98	or	or	CC
cord-280878-1kt51viz	503	99	luciferase	luciferase	JJ
cord-280878-1kt51viz	503	100	in	in	IN
cord-280878-1kt51viz	503	101	modified	modify	VBN
cord-280878-1kt51viz	503	102	JFH1	JFH1	NNP
cord-280878-1kt51viz	504	1	NS5A	NS5A	NNP
cord-280878-1kt51viz	505	1	A	a	DT
cord-280878-1kt51viz	505	2	live	live	JJ
cord-280878-1kt51viz	505	3	,	,	,
cord-280878-1kt51viz	505	4	impaired	impair	VBN
cord-280878-1kt51viz	505	5	-	-	HYPH
cord-280878-1kt51viz	505	6	fidelity	fidelity	NN
cord-280878-1kt51viz	505	7	coronavirus	coronavirus	NN
cord-280878-1kt51viz	505	8	vaccine	vaccine	NN
cord-280878-1kt51viz	505	9	protects	protect	VBZ
cord-280878-1kt51viz	505	10	in	in	IN
cord-280878-1kt51viz	505	11	an	an	DT
cord-280878-1kt51viz	505	12	aged	aged	JJ
cord-280878-1kt51viz	505	13	,	,	,
cord-280878-1kt51viz	505	14	immunocompromised	immunocompromised	JJ
cord-280878-1kt51viz	505	15	mouse	mouse	NN
cord-280878-1kt51viz	505	16	model	model	NN
cord-280878-1kt51viz	505	17	of	of	IN
cord-280878-1kt51viz	505	18	lethal	lethal	JJ
cord-280878-1kt51viz	505	19	disease	disease	NN
cord-280878-1kt51viz	505	20	Influence	influence	NN
cord-280878-1kt51viz	505	21	of	of	IN
cord-280878-1kt51viz	505	22	amantadine	amantadine	NNP
cord-280878-1kt51viz	505	23	resistance	resistance	NN
cord-280878-1kt51viz	505	24	mutations	mutation	NNS
cord-280878-1kt51viz	505	25	on	on	IN
cord-280878-1kt51viz	505	26	the	the	DT
cord-280878-1kt51viz	505	27	pH	pH	NNP
cord-280878-1kt51viz	505	28	regulatory	regulatory	JJ
cord-280878-1kt51viz	505	29	function	function	NN
cord-280878-1kt51viz	505	30	of	of	IN
cord-280878-1kt51viz	505	31	the	the	DT
cord-280878-1kt51viz	505	32	M2	M2	NNP
cord-280878-1kt51viz	505	33	protein	protein	NN
cord-280878-1kt51viz	505	34	of	of	IN
cord-280878-1kt51viz	505	35	influenza	influenza	NN
cord-280878-1kt51viz	505	36	A	a	DT
cord-280878-1kt51viz	505	37	viruses	virus	NNS
cord-280878-1kt51viz	505	38	Maturation	Maturation	NNP
cord-280878-1kt51viz	505	39	of	of	IN
cord-280878-1kt51viz	505	40	influenza	influenza	NN
cord-280878-1kt51viz	505	41	A	a	DT
cord-280878-1kt51viz	505	42	virus	virus	NN
cord-280878-1kt51viz	506	1	hemagglutinin	hemagglutinin	NN
cord-280878-1kt51viz	506	2	-	-	:
cord-280878-1kt51viz	506	3	Estimates	estimate	NNS
cord-280878-1kt51viz	506	4	of	of	IN
cord-280878-1kt51viz	506	5	the	the	DT
cord-280878-1kt51viz	506	6	pH	pH	NNP
cord-280878-1kt51viz	506	7	encountered	encounter	VBN
cord-280878-1kt51viz	506	8	during	during	IN
cord-280878-1kt51viz	506	9	transport	transport	NN
cord-280878-1kt51viz	506	10	and	and	CC
cord-280878-1kt51viz	506	11	its	-PRON-	PRP$
cord-280878-1kt51viz	506	12	regulation	regulation	NN
cord-280878-1kt51viz	506	13	by	by	IN
cord-280878-1kt51viz	506	14	the	the	DT
cord-280878-1kt51viz	506	15	M2	M2	NNP
cord-280878-1kt51viz	506	16	protein	protein	NN
cord-280878-1kt51viz	506	17	The	the	DT
cord-280878-1kt51viz	506	18	p7	p7	NN
cord-280878-1kt51viz	506	19	protein	protein	NN
cord-280878-1kt51viz	506	20	of	of	IN
cord-280878-1kt51viz	506	21	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	506	22	C	C	NNP
cord-280878-1kt51viz	506	23	virus	virus	NN
cord-280878-1kt51viz	506	24	forms	form	VBZ
cord-280878-1kt51viz	506	25	an	an	DT
cord-280878-1kt51viz	506	26	ion	ion	NN
cord-280878-1kt51viz	506	27	channel	channel	NN
cord-280878-1kt51viz	506	28	that	that	WDT
cord-280878-1kt51viz	506	29	is	be	VBZ
cord-280878-1kt51viz	506	30	blocked	block	VBN
cord-280878-1kt51viz	506	31	by	by	IN
cord-280878-1kt51viz	506	32	the	the	DT
cord-280878-1kt51viz	506	33	antiviral	antiviral	JJ
cord-280878-1kt51viz	506	34	drug	drug	NN
cord-280878-1kt51viz	506	35	Genotype	genotype	NN
cord-280878-1kt51viz	506	36	-	-	HYPH
cord-280878-1kt51viz	506	37	dependent	dependent	JJ
cord-280878-1kt51viz	506	38	sensitivity	sensitivity	NN
cord-280878-1kt51viz	506	39	of	of	IN
cord-280878-1kt51viz	506	40	hepatitis	hepatitis	NN
cord-280878-1kt51viz	506	41	C	C	NNP
cord-280878-1kt51viz	506	42	virus	virus	NN
cord-280878-1kt51viz	506	43	to	to	IN
cord-280878-1kt51viz	506	44	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	506	45	of	of	IN
cord-280878-1kt51viz	506	46	the	the	DT
cord-280878-1kt51viz	506	47	p7	p7	NN
cord-280878-1kt51viz	506	48	ion	ion	NN
cord-280878-1kt51viz	506	49	channel	channel	NN
cord-280878-1kt51viz	506	50	Structural	structural	JJ
cord-280878-1kt51viz	506	51	and	and	CC
cord-280878-1kt51viz	506	52	energetic	energetic	JJ
cord-280878-1kt51viz	506	53	analysis	analysis	NN
cord-280878-1kt51viz	506	54	of	of	IN
cord-280878-1kt51viz	506	55	drug	drug	NN
cord-280878-1kt51viz	506	56	inhibition	inhibition	NN
cord-280878-1kt51viz	506	57	of	of	IN
cord-280878-1kt51viz	506	58	the	the	DT
cord-280878-1kt51viz	506	59	influenza	influenza	NN
cord-280878-1kt51viz	506	60	A	a	DT
cord-280878-1kt51viz	506	61	M2	M2	NNP
cord-280878-1kt51viz	506	62	proton	proton	NN
cord-280878-1kt51viz	506	63	channel	channel	NN
cord-280878-1kt51viz	506	64	Free	free	JJ
cord-280878-1kt51viz	506	65	energy	energy	NN
cord-280878-1kt51viz	506	66	calculations	calculation	NNS
cord-280878-1kt51viz	506	67	on	on	IN
cord-280878-1kt51viz	506	68	the	the	DT
cord-280878-1kt51viz	506	69	two	two	CD
cord-280878-1kt51viz	506	70	drug	drug	NN
cord-280878-1kt51viz	506	71	binding	bind	VBG
cord-280878-1kt51viz	506	72	sites	site	NNS
cord-280878-1kt51viz	506	73	in	in	IN
cord-280878-1kt51viz	506	74	the	the	DT
cord-280878-1kt51viz	506	75	M2	m2	JJ
cord-280878-1kt51viz	506	76	proton	proton	NN
cord-280878-1kt51viz	506	77	channel	channel	NN
cord-280878-1kt51viz	507	1	NLRP3	NLRP3	NNP
cord-280878-1kt51viz	508	1	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	508	2	activation	activation	NN
cord-280878-1kt51viz	508	3	by	by	IN
cord-280878-1kt51viz	508	4	viroporins	viroporin	NNS
cord-280878-1kt51viz	508	5	of	of	IN
cord-280878-1kt51viz	508	6	animal	animal	NN
cord-280878-1kt51viz	508	7	viruses	virus	NNS
cord-280878-1kt51viz	508	8	Respiratory	respiratory	JJ
cord-280878-1kt51viz	508	9	syncytial	syncytial	JJ
cord-280878-1kt51viz	508	10	viral	viral	JJ
cord-280878-1kt51viz	508	11	-	-	HYPH
cord-280878-1kt51viz	508	12	infection	infection	NN
cord-280878-1kt51viz	508	13	in	in	IN
cord-280878-1kt51viz	508	14	children	child	NNS
cord-280878-1kt51viz	508	15	with	with	IN
cord-280878-1kt51viz	508	16	compromised	compromise	VBN
cord-280878-1kt51viz	508	17	immune	immune	JJ
cord-280878-1kt51viz	508	18	function	function	NN
cord-280878-1kt51viz	509	1	A	a	DT
cord-280878-1kt51viz	509	2	2a/1b	2a/1b	CD
cord-280878-1kt51viz	509	3	fulllength	fulllength	NN
cord-280878-1kt51viz	509	4	p7	p7	FW
cord-280878-1kt51viz	509	5	inter	inter	JJ
cord-280878-1kt51viz	509	6	-	-	JJ
cord-280878-1kt51viz	509	7	genotypic	genotypic	JJ
cord-280878-1kt51viz	509	8	chimeric	chimeric	JJ
cord-280878-1kt51viz	509	9	genome	genome	NN
cord-280878-1kt51viz	509	10	of	of	IN
cord-280878-1kt51viz	509	11	hepatitis	hepatitis	NN
cord-280878-1kt51viz	509	12	C	C	NNP
cord-280878-1kt51viz	509	13	virus	virus	NN
cord-280878-1kt51viz	509	14	is	be	VBZ
cord-280878-1kt51viz	509	15	infectious	infectious	JJ
cord-280878-1kt51viz	509	16	in	in	IN
cord-280878-1kt51viz	509	17	vitro	vitro	FW
cord-280878-1kt51viz	510	1	E2-p7	e2-p7	CC
cord-280878-1kt51viz	510	2	region	region	NN
cord-280878-1kt51viz	510	3	of	of	IN
cord-280878-1kt51viz	510	4	the	the	DT
cord-280878-1kt51viz	510	5	bovine	bovine	JJ
cord-280878-1kt51viz	510	6	viral	viral	JJ
cord-280878-1kt51viz	510	7	diarrhea	diarrhea	NN
cord-280878-1kt51viz	510	8	virus	virus	NN
cord-280878-1kt51viz	510	9	polyprotein	polyprotein	NN
cord-280878-1kt51viz	510	10	:	:	:
cord-280878-1kt51viz	511	1	Processing	processing	NN
cord-280878-1kt51viz	511	2	and	and	CC
cord-280878-1kt51viz	511	3	functional	functional	JJ
cord-280878-1kt51viz	511	4	studies	study	NNS
cord-280878-1kt51viz	511	5	Influenza	Influenza	NNP
cord-280878-1kt51viz	511	6	B	B	NNP
cord-280878-1kt51viz	511	7	virus	virus	NN
cord-280878-1kt51viz	511	8	requires	require	VBZ
cord-280878-1kt51viz	511	9	BM2	BM2	NNP
cord-280878-1kt51viz	511	10	protein	protein	NN
cord-280878-1kt51viz	511	11	for	for	IN
cord-280878-1kt51viz	511	12	replication	replication	NN
cord-280878-1kt51viz	512	1	The	the	DT
cord-280878-1kt51viz	512	2	evolution	evolution	NN
cord-280878-1kt51viz	512	3	of	of	IN
cord-280878-1kt51viz	512	4	human	human	JJ
cord-280878-1kt51viz	512	5	influenza	influenza	NN
cord-280878-1kt51viz	512	6	viruses	virus	NNS
cord-280878-1kt51viz	513	1	The	the	DT
cord-280878-1kt51viz	513	2	molecular	molecular	JJ
cord-280878-1kt51viz	513	3	basis	basis	NN
cord-280878-1kt51viz	513	4	of	of	IN
cord-280878-1kt51viz	513	5	the	the	DT
cord-280878-1kt51viz	513	6	specific	specific	JJ
cord-280878-1kt51viz	513	7	anti	anti	JJ
cord-280878-1kt51viz	513	8	-	-	JJ
cord-280878-1kt51viz	513	9	influenza	influenza	JJ
cord-280878-1kt51viz	513	10	action	action	NN
cord-280878-1kt51viz	513	11	of	of	IN
cord-280878-1kt51viz	513	12	amantadine	amantadine	NNP
cord-280878-1kt51viz	513	13	Emerging	Emerging	NNP
cord-280878-1kt51viz	513	14	influenza	influenza	NN
cord-280878-1kt51viz	513	15	antiviral	antiviral	JJ
cord-280878-1kt51viz	513	16	resistance	resistance	NN
cord-280878-1kt51viz	513	17	threats	threat	NNS
cord-280878-1kt51viz	513	18	Ready	ready	JJ
cord-280878-1kt51viz	513	19	,	,	,
cord-280878-1kt51viz	513	20	set	set	VBN
cord-280878-1kt51viz	513	21	,	,	,
cord-280878-1kt51viz	513	22	fuse	fuse	NN
cord-280878-1kt51viz	513	23	!	!	.
cord-280878-1kt51viz	514	1	The	the	DT
cord-280878-1kt51viz	514	2	coronavirus	coronavirus	NN
cord-280878-1kt51viz	514	3	spike	spike	NN
cord-280878-1kt51viz	514	4	protein	protein	NN
cord-280878-1kt51viz	514	5	and	and	CC
cord-280878-1kt51viz	514	6	acquisition	acquisition	NN
cord-280878-1kt51viz	514	7	of	of	IN
cord-280878-1kt51viz	514	8	fusion	fusion	NN
cord-280878-1kt51viz	514	9	competence	competence	NN
cord-280878-1kt51viz	514	10	Effect	effect	NN
cord-280878-1kt51viz	514	11	of	of	IN
cord-280878-1kt51viz	514	12	ribavirin	ribavirin	NN
cord-280878-1kt51viz	514	13	on	on	IN
cord-280878-1kt51viz	514	14	hepatitis	hepatitis	NN
cord-280878-1kt51viz	514	15	C	C	NNP
cord-280878-1kt51viz	514	16	viral	viral	JJ
cord-280878-1kt51viz	514	17	kinetics	kinetic	NNS
cord-280878-1kt51viz	514	18	in	in	IN
cord-280878-1kt51viz	514	19	patients	patient	NNS
cord-280878-1kt51viz	514	20	treated	treat	VBN
cord-280878-1kt51viz	514	21	with	with	IN
cord-280878-1kt51viz	514	22	pegylated	pegylated	JJ
cord-280878-1kt51viz	514	23	interferon	interferon	NN
cord-280878-1kt51viz	514	24	Coronavirus	Coronavirus	NNP
cord-280878-1kt51viz	514	25	structural	structural	JJ
cord-280878-1kt51viz	514	26	proteins	protein	NNS
cord-280878-1kt51viz	514	27	and	and	CC
cord-280878-1kt51viz	514	28	virus	virus	NN
cord-280878-1kt51viz	514	29	assembly	assembly	NN
cord-280878-1kt51viz	514	30	SARS	SARS	NNP
cord-280878-1kt51viz	514	31	coronavirus	coronavirus	NN
cord-280878-1kt51viz	514	32	:	:	:
cord-280878-1kt51viz	514	33	A	a	DT
cord-280878-1kt51viz	514	34	new	new	JJ
cord-280878-1kt51viz	514	35	challenge	challenge	NN
cord-280878-1kt51viz	514	36	for	for	IN
cord-280878-1kt51viz	514	37	prevention	prevention	NN
cord-280878-1kt51viz	514	38	and	and	CC
cord-280878-1kt51viz	514	39	therapy	therapy	NN
cord-280878-1kt51viz	514	40	Treatment	Treatment	NNP
cord-280878-1kt51viz	514	41	of	of	IN
cord-280878-1kt51viz	514	42	chronic	chronic	JJ
cord-280878-1kt51viz	514	43	non	non	JJ
cord-280878-1kt51viz	514	44	-	-	JJ
cord-280878-1kt51viz	514	45	a	a	DT
cord-280878-1kt51viz	514	46	non	non	JJ
cord-280878-1kt51viz	514	47	-	-	JJ
cord-280878-1kt51viz	514	48	B	b	JJ
cord-280878-1kt51viz	514	49	hepatitis	hepatitis	NN
cord-280878-1kt51viz	514	50	with	with	IN
cord-280878-1kt51viz	514	51	recombinant	recombinant	JJ
cord-280878-1kt51viz	514	52	human	human	JJ
cord-280878-1kt51viz	514	53	alpha	alpha	NN
cord-280878-1kt51viz	514	54	-	-	HYPH
cord-280878-1kt51viz	514	55	interferon	interferon	JJ
cord-280878-1kt51viz	514	56	Scrambling	Scrambling	NNP
cord-280878-1kt51viz	514	57	of	of	IN
cord-280878-1kt51viz	514	58	the	the	DT
cord-280878-1kt51viz	514	59	amino	amino	NN
cord-280878-1kt51viz	514	60	acids	acid	NNS
cord-280878-1kt51viz	514	61	within	within	IN
cord-280878-1kt51viz	514	62	the	the	DT
cord-280878-1kt51viz	514	63	transmembrane	transmembrane	NN
cord-280878-1kt51viz	514	64	domain	domain	NN
cord-280878-1kt51viz	514	65	of	of	IN
cord-280878-1kt51viz	514	66	Vpu	Vpu	NNP
cord-280878-1kt51viz	514	67	results	result	NNS
cord-280878-1kt51viz	514	68	in	in	IN
cord-280878-1kt51viz	514	69	a	a	DT
cord-280878-1kt51viz	514	70	simian	simian	JJ
cord-280878-1kt51viz	514	71	-	-	HYPH
cord-280878-1kt51viz	514	72	human	human	JJ
cord-280878-1kt51viz	514	73	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	514	74	virus	virus	NN
cord-280878-1kt51viz	514	75	(	(	-LRB-
cord-280878-1kt51viz	514	76	SHIVTM	SHIVTM	NNP
cord-280878-1kt51viz	514	77	)	)	-RRB-
cord-280878-1kt51viz	514	78	that	that	DT
cord-280878-1kt51viz	514	79	is	be	VBZ
cord-280878-1kt51viz	514	80	less	less	RBR
cord-280878-1kt51viz	514	81	pathogenic	pathogenic	JJ
cord-280878-1kt51viz	514	82	for	for	IN
cord-280878-1kt51viz	514	83	pig	pig	NN
cord-280878-1kt51viz	514	84	-	-	HYPH
cord-280878-1kt51viz	514	85	tailed	tail	VBN
cord-280878-1kt51viz	514	86	macaques	macaque	NNS
cord-280878-1kt51viz	515	1	A	a	DT
cord-280878-1kt51viz	515	2	single	single	JJ
cord-280878-1kt51viz	515	3	amino	amino	NN
cord-280878-1kt51viz	515	4	acid	acid	NN
cord-280878-1kt51viz	515	5	substitution	substitution	NN
cord-280878-1kt51viz	515	6	within	within	IN
cord-280878-1kt51viz	515	7	the	the	DT
cord-280878-1kt51viz	515	8	transmembrane	transmembrane	NN
cord-280878-1kt51viz	515	9	domain	domain	NN
cord-280878-1kt51viz	515	10	of	of	IN
cord-280878-1kt51viz	515	11	the	the	DT
cord-280878-1kt51viz	515	12	human	human	JJ
cord-280878-1kt51viz	515	13	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	515	14	virus	virus	NN
cord-280878-1kt51viz	515	15	type	type	NN
cord-280878-1kt51viz	515	16	1	1	CD
cord-280878-1kt51viz	515	17	Vpu	Vpu	NNP
cord-280878-1kt51viz	515	18	protein	protein	NN
cord-280878-1kt51viz	515	19	renders	render	VBZ
cord-280878-1kt51viz	515	20	simian	simian	JJ
cord-280878-1kt51viz	515	21	-	-	HYPH
cord-280878-1kt51viz	515	22	human	human	JJ
cord-280878-1kt51viz	515	23	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	515	24	virus	virus	NN
cord-280878-1kt51viz	515	25	(	(	-LRB-
cord-280878-1kt51viz	515	26	SHIVKU-1bMC33	SHIVKU-1bMC33	NNP
cord-280878-1kt51viz	515	27	)	)	-RRB-
cord-280878-1kt51viz	515	28	susceptible	susceptible	JJ
cord-280878-1kt51viz	515	29	to	to	IN
cord-280878-1kt51viz	515	30	rimantadine	rimantadine	NNP
cord-280878-1kt51viz	516	1	In	in	IN
cord-280878-1kt51viz	516	2	silico	silico	NN
cord-280878-1kt51viz	516	3	investigations	investigation	NNS
cord-280878-1kt51viz	516	4	of	of	IN
cord-280878-1kt51viz	516	5	possible	possible	JJ
cord-280878-1kt51viz	516	6	routes	route	NNS
cord-280878-1kt51viz	516	7	of	of	IN
cord-280878-1kt51viz	516	8	assembly	assembly	NN
cord-280878-1kt51viz	516	9	of	of	IN
cord-280878-1kt51viz	516	10	ORF	ORF	NNP
cord-280878-1kt51viz	516	11	3a	3a	NNP
cord-280878-1kt51viz	516	12	from	from	IN
cord-280878-1kt51viz	516	13	SARS	SARS	NNP
cord-280878-1kt51viz	516	14	-	-	HYPH
cord-280878-1kt51viz	516	15	CoV	CoV	NNP
cord-280878-1kt51viz	516	16	Membrane	Membrane	NNP
cord-280878-1kt51viz	516	17	potential	potential	JJ
cord-280878-1kt51viz	516	18	depolarization	depolarization	NN
cord-280878-1kt51viz	516	19	as	as	IN
cord-280878-1kt51viz	516	20	a	a	DT
cord-280878-1kt51viz	516	21	triggering	trigger	VBG
cord-280878-1kt51viz	516	22	mechanism	mechanism	NN
cord-280878-1kt51viz	516	23	for	for	IN
cord-280878-1kt51viz	516	24	Vpu	Vpu	NNP
cord-280878-1kt51viz	516	25	-	-	HYPH
cord-280878-1kt51viz	516	26	mediated	mediate	VBN
cord-280878-1kt51viz	516	27	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	516	28	release	release	NN
cord-280878-1kt51viz	516	29	Identification	identification	NN
cord-280878-1kt51viz	516	30	of	of	IN
cord-280878-1kt51viz	516	31	hits	hit	NNS
cord-280878-1kt51viz	516	32	as	as	IN
cord-280878-1kt51viz	516	33	matrix-2	matrix-2	NNP
cord-280878-1kt51viz	516	34	protein	protein	NN
cord-280878-1kt51viz	516	35	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	516	36	through	through	IN
cord-280878-1kt51viz	516	37	the	the	DT
cord-280878-1kt51viz	516	38	focused	focused	JJ
cord-280878-1kt51viz	516	39	screening	screening	NN
cord-280878-1kt51viz	516	40	of	of	IN
cord-280878-1kt51viz	516	41	a	a	DT
cord-280878-1kt51viz	516	42	small	small	JJ
cord-280878-1kt51viz	516	43	primary	primary	JJ
cord-280878-1kt51viz	516	44	amine	amine	NN
cord-280878-1kt51viz	516	45	library	library	NN
cord-280878-1kt51viz	516	46	Influenza	Influenza	NNP
cord-280878-1kt51viz	516	47	virus	virus	NN
cord-280878-1kt51viz	516	48	activates	activate	VBZ
cord-280878-1kt51viz	516	49	inflammasomes	inflammasome	NNS
cord-280878-1kt51viz	516	50	via	via	IN
cord-280878-1kt51viz	516	51	its	-PRON-	PRP$
cord-280878-1kt51viz	516	52	intracellular	intracellular	JJ
cord-280878-1kt51viz	516	53	M2	M2	NNP
cord-280878-1kt51viz	516	54	ion	ion	NN
cord-280878-1kt51viz	516	55	channel	channel	NN
cord-280878-1kt51viz	516	56	S	s	NN
cord-280878-1kt51viz	516	57	-	-	HYPH
cord-280878-1kt51viz	516	58	layer	layer	NN
cord-280878-1kt51viz	516	59	fusion	fusion	NN
cord-280878-1kt51viz	516	60	proteins	protein	NNS
cord-280878-1kt51viz	516	61	-	-	:
cord-280878-1kt51viz	516	62	construction	construction	NN
cord-280878-1kt51viz	516	63	principles	principle	NNS
cord-280878-1kt51viz	516	64	and	and	CC
cord-280878-1kt51viz	516	65	applications	application	NNS
cord-280878-1kt51viz	516	66	Cytoplasmic	Cytoplasmic	NNP
cord-280878-1kt51viz	516	67	domain	domain	NN
cord-280878-1kt51viz	516	68	of	of	IN
cord-280878-1kt51viz	516	69	influenza	influenza	NN
cord-280878-1kt51viz	516	70	B	B	NNP
cord-280878-1kt51viz	516	71	virus	virus	NN
cord-280878-1kt51viz	516	72	BM2	BM2	NNP
cord-280878-1kt51viz	516	73	protein	protein	NN
cord-280878-1kt51viz	516	74	plays	play	VBZ
cord-280878-1kt51viz	516	75	critical	critical	JJ
cord-280878-1kt51viz	516	76	roles	role	NNS
cord-280878-1kt51viz	516	77	in	in	IN
cord-280878-1kt51viz	516	78	production	production	NN
cord-280878-1kt51viz	516	79	of	of	IN
cord-280878-1kt51viz	516	80	infectious	infectious	JJ
cord-280878-1kt51viz	516	81	virus	virus	NN
cord-280878-1kt51viz	517	1	Influenza	Influenza	NNP
cord-280878-1kt51viz	517	2	B	B	NNP
cord-280878-1kt51viz	517	3	virus	virus	NN
cord-280878-1kt51viz	517	4	BM2	BM2	NNP
cord-280878-1kt51viz	517	5	protein	protein	NN
cord-280878-1kt51viz	517	6	is	be	VBZ
cord-280878-1kt51viz	517	7	a	a	DT
cord-280878-1kt51viz	517	8	crucial	crucial	JJ
cord-280878-1kt51viz	517	9	component	component	NN
cord-280878-1kt51viz	517	10	for	for	IN
cord-280878-1kt51viz	517	11	incorporation	incorporation	NN
cord-280878-1kt51viz	517	12	of	of	IN
cord-280878-1kt51viz	517	13	viral	viral	JJ
cord-280878-1kt51viz	517	14	ribonucleoprotein	ribonucleoprotein	NN
cord-280878-1kt51viz	517	15	complex	complex	NN
cord-280878-1kt51viz	517	16	into	into	IN
cord-280878-1kt51viz	517	17	virions	virion	NNS
cord-280878-1kt51viz	517	18	during	during	IN
cord-280878-1kt51viz	517	19	virus	virus	NN
cord-280878-1kt51viz	517	20	assembly	assembly	NN
cord-280878-1kt51viz	517	21	Encephalomyocarditis	Encephalomyocarditis	NNP
cord-280878-1kt51viz	517	22	virus	virus	NN
cord-280878-1kt51viz	517	23	viroporin	viroporin	NNP
cord-280878-1kt51viz	517	24	2B	2B	NNP
cord-280878-1kt51viz	517	25	activates	activate	VBZ
cord-280878-1kt51viz	517	26	NLRP3	NLRP3	NNP
cord-280878-1kt51viz	517	27	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	518	1	A	a	DT
cord-280878-1kt51viz	518	2	pseudo	pseudo	JJ
cord-280878-1kt51viz	518	3	-	-	NN
cord-280878-1kt51viz	518	4	revertant	revertant	JJ
cord-280878-1kt51viz	518	5	of	of	IN
cord-280878-1kt51viz	518	6	a	a	DT
cord-280878-1kt51viz	518	7	Sindbis	Sindbis	NNP
cord-280878-1kt51viz	518	8	virus	virus	NN
cord-280878-1kt51viz	518	9	6	6	CD
cord-280878-1kt51viz	518	10	K	k	NN
cord-280878-1kt51viz	518	11	protein	protein	NN
cord-280878-1kt51viz	518	12	mutant	mutant	NN
cord-280878-1kt51viz	518	13	,	,	,
cord-280878-1kt51viz	518	14	which	which	WDT
cord-280878-1kt51viz	518	15	corrects	correct	VBZ
cord-280878-1kt51viz	518	16	for	for	IN
cord-280878-1kt51viz	518	17	aberrant	aberrant	JJ
cord-280878-1kt51viz	518	18	particle	particle	NN
cord-280878-1kt51viz	518	19	formation	formation	NN
cord-280878-1kt51viz	518	20	,	,	,
cord-280878-1kt51viz	518	21	contains	contain	VBZ
cord-280878-1kt51viz	518	22	two	two	CD
cord-280878-1kt51viz	518	23	new	new	JJ
cord-280878-1kt51viz	518	24	mutations	mutation	NNS
cord-280878-1kt51viz	518	25	that	that	WDT
cord-280878-1kt51viz	518	26	map	map	VBP
cord-280878-1kt51viz	518	27	to	to	IN
cord-280878-1kt51viz	518	28	the	the	DT
cord-280878-1kt51viz	518	29	ectodomain	ectodomain	NN
cord-280878-1kt51viz	518	30	of	of	IN
cord-280878-1kt51viz	518	31	the	the	DT
cord-280878-1kt51viz	518	32	E2	E2	NNP
cord-280878-1kt51viz	518	33	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	519	1	The	the	DT
cord-280878-1kt51viz	519	2	complete	complete	JJ
cord-280878-1kt51viz	519	3	genome	genome	NN
cord-280878-1kt51viz	519	4	sequence	sequence	NN
cord-280878-1kt51viz	519	5	of	of	IN
cord-280878-1kt51viz	519	6	J	J	NNP
cord-280878-1kt51viz	519	7	virus	virus	NN
cord-280878-1kt51viz	519	8	reveals	reveal	VBZ
cord-280878-1kt51viz	519	9	a	a	DT
cord-280878-1kt51viz	519	10	unique	unique	JJ
cord-280878-1kt51viz	519	11	genome	genome	NN
cord-280878-1kt51viz	519	12	structure	structure	NN
cord-280878-1kt51viz	519	13	in	in	IN
cord-280878-1kt51viz	519	14	the	the	DT
cord-280878-1kt51viz	519	15	family	family	NN
cord-280878-1kt51viz	520	1	Paramyxoviridae	Paramyxoviridae	NNP
cord-280878-1kt51viz	520	2	Emerging	Emerging	NNP
cord-280878-1kt51viz	520	3	theme	theme	NN
cord-280878-1kt51viz	520	4	:	:	:
cord-280878-1kt51viz	521	1	Cellular	cellular	JJ
cord-280878-1kt51viz	521	2	PDZ	PDZ	NNP
cord-280878-1kt51viz	521	3	proteins	protein	NNS
cord-280878-1kt51viz	521	4	as	as	IN
cord-280878-1kt51viz	521	5	common	common	JJ
cord-280878-1kt51viz	521	6	targets	target	NNS
cord-280878-1kt51viz	521	7	of	of	IN
cord-280878-1kt51viz	521	8	pathogenic	pathogenic	JJ
cord-280878-1kt51viz	521	9	viruses	virus	NNS
cord-280878-1kt51viz	522	1	Recombinant	recombinant	JJ
cord-280878-1kt51viz	522	2	respiratory	respiratory	JJ
cord-280878-1kt51viz	522	3	syncytial	syncytial	JJ
cord-280878-1kt51viz	522	4	viruses	virus	NNS
cord-280878-1kt51viz	522	5	with	with	IN
cord-280878-1kt51viz	522	6	deletions	deletion	NNS
cord-280878-1kt51viz	522	7	in	in	IN
cord-280878-1kt51viz	522	8	the	the	DT
cord-280878-1kt51viz	522	9	NS1	NS1	NNS
cord-280878-1kt51viz	522	10	,	,	,
cord-280878-1kt51viz	522	11	NS2	NS2	NNP
cord-280878-1kt51viz	522	12	,	,	,
cord-280878-1kt51viz	522	13	SH	SH	NNP
cord-280878-1kt51viz	522	14	,	,	,
cord-280878-1kt51viz	522	15	and	and	CC
cord-280878-1kt51viz	522	16	M2	M2	NNP
cord-280878-1kt51viz	522	17	-	-	HYPH
cord-280878-1kt51viz	522	18	2	2	CD
cord-280878-1kt51viz	522	19	genes	gene	NNS
cord-280878-1kt51viz	522	20	are	be	VBP
cord-280878-1kt51viz	522	21	attenuated	attenuate	VBN
cord-280878-1kt51viz	522	22	in	in	IN
cord-280878-1kt51viz	522	23	vitro	vitro	FW
cord-280878-1kt51viz	522	24	and	and	CC
cord-280878-1kt51viz	522	25	in	in	IN
cord-280878-1kt51viz	522	26	vivo	vivo	NNP
cord-280878-1kt51viz	522	27	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	522	28	C	C	NNP
cord-280878-1kt51viz	522	29	virus	virus	NN
cord-280878-1kt51viz	522	30	p7	p7	NN
cord-280878-1kt51viz	522	31	and	and	CC
cord-280878-1kt51viz	522	32	NS2	NS2	NNP
cord-280878-1kt51viz	522	33	proteins	protein	NNS
cord-280878-1kt51viz	522	34	are	be	VBP
cord-280878-1kt51viz	522	35	essential	essential	JJ
cord-280878-1kt51viz	522	36	for	for	IN
cord-280878-1kt51viz	522	37	production	production	NN
cord-280878-1kt51viz	522	38	of	of	IN
cord-280878-1kt51viz	522	39	infectious	infectious	JJ
cord-280878-1kt51viz	522	40	virus	virus	NN
cord-280878-1kt51viz	522	41	Respiratory	respiratory	JJ
cord-280878-1kt51viz	522	42	syncytial	syncytial	JJ
cord-280878-1kt51viz	522	43	virus	virus	NN
cord-280878-1kt51viz	523	1	(	(	-LRB-
cord-280878-1kt51viz	523	2	RSV	RSV	NNP
cord-280878-1kt51viz	523	3	)	)	-RRB-
cord-280878-1kt51viz	523	4	SH	sh	NN
cord-280878-1kt51viz	523	5	and	and	CC
cord-280878-1kt51viz	523	6	G	g	NN
cord-280878-1kt51viz	523	7	proteins	protein	NNS
cord-280878-1kt51viz	523	8	are	be	VBP
cord-280878-1kt51viz	523	9	not	not	RB
cord-280878-1kt51viz	523	10	essential	essential	JJ
cord-280878-1kt51viz	523	11	for	for	IN
cord-280878-1kt51viz	523	12	viral	viral	JJ
cord-280878-1kt51viz	523	13	replication	replication	NN
cord-280878-1kt51viz	523	14	in	in	IN
cord-280878-1kt51viz	523	15	vitro	vitro	FW
cord-280878-1kt51viz	523	16	:	:	:
cord-280878-1kt51viz	524	1	Clinical	clinical	JJ
cord-280878-1kt51viz	524	2	evaluation	evaluation	NN
cord-280878-1kt51viz	524	3	and	and	CC
cord-280878-1kt51viz	524	4	molecular	molecular	JJ
cord-280878-1kt51viz	524	5	characterization	characterization	NN
cord-280878-1kt51viz	524	6	of	of	IN
cord-280878-1kt51viz	524	7	a	a	DT
cord-280878-1kt51viz	524	8	cold	cold	JJ
cord-280878-1kt51viz	524	9	-	-	HYPH
cord-280878-1kt51viz	524	10	passaged	passaged	JJ
cord-280878-1kt51viz	524	11	,	,	,
cord-280878-1kt51viz	524	12	attenuated	attenuated	JJ
cord-280878-1kt51viz	524	13	RSV	RSV	NNP
cord-280878-1kt51viz	524	14	subgroup	subgroup	NN
cord-280878-1kt51viz	524	15	B	b	NN
cord-280878-1kt51viz	524	16	mutant	mutant	JJ
cord-280878-1kt51viz	524	17	Efficient	efficient	JJ
cord-280878-1kt51viz	524	18	replication	replication	NN
cord-280878-1kt51viz	524	19	of	of	IN
cord-280878-1kt51viz	524	20	the	the	DT
cord-280878-1kt51viz	524	21	genotype	genotype	NN
cord-280878-1kt51viz	524	22	2a	2a	CD
cord-280878-1kt51viz	524	23	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	524	24	C	C	NNP
cord-280878-1kt51viz	524	25	virus	virus	NN
cord-280878-1kt51viz	524	26	subgenomic	subgenomic	NNP
cord-280878-1kt51viz	524	27	replicon	replicon	NNP
cord-280878-1kt51viz	524	28	Antiviral	antiviral	JJ
cord-280878-1kt51viz	524	29	efficacy	efficacy	NN
cord-280878-1kt51viz	524	30	of	of	IN
cord-280878-1kt51viz	524	31	the	the	DT
cord-280878-1kt51viz	524	32	novel	novel	JJ
cord-280878-1kt51viz	524	33	compound	compound	NN
cord-280878-1kt51viz	524	34	BIT225	BIT225	NNP
cord-280878-1kt51viz	524	35	against	against	IN
cord-280878-1kt51viz	524	36	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	524	37	release	release	NN
cord-280878-1kt51viz	524	38	from	from	IN
cord-280878-1kt51viz	524	39	human	human	JJ
cord-280878-1kt51viz	524	40	macrophages	macrophage	NNS
cord-280878-1kt51viz	524	41	.	.	.
cord-280878-1kt51viz	525	1	Antimicrobial	Antimicrobial	NNP
cord-280878-1kt51viz	525	2	Agents	Agents	NNPS
cord-280878-1kt51viz	525	3	and	and	CC
cord-280878-1kt51viz	525	4	Cell	cell	NN
cord-280878-1kt51viz	525	5	-	-	HYPH
cord-280878-1kt51viz	525	6	based	base	VBN
cord-280878-1kt51viz	525	7	antiviral	antiviral	JJ
cord-280878-1kt51viz	525	8	screening	screening	NN
cord-280878-1kt51viz	525	9	against	against	IN
cord-280878-1kt51viz	525	10	coronaviruses	coronaviruse	NNS
cord-280878-1kt51viz	525	11	:	:	:
cord-280878-1kt51viz	526	1	Developing	develop	VBG
cord-280878-1kt51viz	526	2	virus	virus	NN
cord-280878-1kt51viz	526	3	-	-	HYPH
cord-280878-1kt51viz	526	4	specific	specific	JJ
cord-280878-1kt51viz	526	5	and	and	CC
cord-280878-1kt51viz	526	6	broad	broad	JJ
cord-280878-1kt51viz	526	7	-	-	HYPH
cord-280878-1kt51viz	526	8	spectrum	spectrum	NN
cord-280878-1kt51viz	526	9	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	526	10	Assessing	assess	VBG
cord-280878-1kt51viz	526	11	activity	activity	NN
cord-280878-1kt51viz	526	12	and	and	CC
cord-280878-1kt51viz	526	13	inhibition	inhibition	NN
cord-280878-1kt51viz	526	14	of	of	IN
cord-280878-1kt51viz	526	15	Middle	Middle	NNP
cord-280878-1kt51viz	526	16	East	East	NNP
cord-280878-1kt51viz	526	17	respiratory	respiratory	JJ
cord-280878-1kt51viz	526	18	syndrome	syndrome	NN
cord-280878-1kt51viz	526	19	coronavirus	coronavirus	NN
cord-280878-1kt51viz	526	20	papain	papain	NN
cord-280878-1kt51viz	526	21	-	-	HYPH
cord-280878-1kt51viz	526	22	like	like	JJ
cord-280878-1kt51viz	526	23	and	and	CC
cord-280878-1kt51viz	526	24	3C	3c	NN
cord-280878-1kt51viz	526	25	-	-	HYPH
cord-280878-1kt51viz	526	26	like	like	JJ
cord-280878-1kt51viz	526	27	proteases	protease	NNS
cord-280878-1kt51viz	526	28	using	use	VBG
cord-280878-1kt51viz	526	29	luciferase	luciferase	NN
cord-280878-1kt51viz	526	30	-	-	HYPH
cord-280878-1kt51viz	526	31	based	base	VBN
cord-280878-1kt51viz	526	32	biosensors	biosensor	NNS
cord-280878-1kt51viz	527	1	The	the	DT
cord-280878-1kt51viz	527	2	human	human	JJ
cord-280878-1kt51viz	527	3	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	527	4	virus	virus	NN
cord-280878-1kt51viz	527	5	type	type	NN
cord-280878-1kt51viz	527	6	1-specific	1-specific	CD
cord-280878-1kt51viz	527	7	protein	protein	NN
cord-280878-1kt51viz	527	8	vpu	vpu	NN
cord-280878-1kt51viz	527	9	is	be	VBZ
cord-280878-1kt51viz	527	10	required	require	VBN
cord-280878-1kt51viz	527	11	for	for	IN
cord-280878-1kt51viz	527	12	efficient	efficient	JJ
cord-280878-1kt51viz	527	13	virus	virus	NN
cord-280878-1kt51viz	527	14	maturation	maturation	NN
cord-280878-1kt51viz	527	15	and	and	CC
cord-280878-1kt51viz	527	16	release	release	VB
cord-280878-1kt51viz	527	17	Helix	Helix	NNP
cord-280878-1kt51viz	527	18	tilt	tilt	NN
cord-280878-1kt51viz	527	19	of	of	IN
cord-280878-1kt51viz	527	20	the	the	DT
cord-280878-1kt51viz	527	21	M2	M2	NNP
cord-280878-1kt51viz	527	22	transmembrane	transmembrane	NN
cord-280878-1kt51viz	527	23	peptide	peptide	NN
cord-280878-1kt51viz	527	24	from	from	IN
cord-280878-1kt51viz	527	25	influenza	influenza	NN
cord-280878-1kt51viz	527	26	A	a	DT
cord-280878-1kt51viz	527	27	virus	virus	NN
cord-280878-1kt51viz	527	28	:	:	:
cord-280878-1kt51viz	527	29	An	an	DT
cord-280878-1kt51viz	527	30	intrinsic	intrinsic	JJ
cord-280878-1kt51viz	527	31	property	property	NN
cord-280878-1kt51viz	527	32	Intranasal	Intranasal	NNP
cord-280878-1kt51viz	527	33	gene	gene	NN
cord-280878-1kt51viz	527	34	transfer	transfer	NN
cord-280878-1kt51viz	527	35	by	by	IN
cord-280878-1kt51viz	527	36	chitosan	chitosan	NN
cord-280878-1kt51viz	527	37	-	-	HYPH
cord-280878-1kt51viz	527	38	DNA	dna	NN
cord-280878-1kt51viz	527	39	nanospheres	nanosphere	NNS
cord-280878-1kt51viz	527	40	protects	protect	VBZ
cord-280878-1kt51viz	527	41	BALB	BALB	NNP
cord-280878-1kt51viz	527	42	/	/	SYM
cord-280878-1kt51viz	527	43	c	c	NN
cord-280878-1kt51viz	527	44	mice	mouse	NNS
cord-280878-1kt51viz	527	45	against	against	IN
cord-280878-1kt51viz	527	46	acute	acute	JJ
cord-280878-1kt51viz	527	47	respiratory	respiratory	JJ
cord-280878-1kt51viz	527	48	syncytial	syncytial	JJ
cord-280878-1kt51viz	527	49	virus	virus	NN
cord-280878-1kt51viz	527	50	infection	infection	NN
cord-280878-1kt51viz	527	51	Growth	growth	NN
cord-280878-1kt51viz	527	52	impairment	impairment	NN
cord-280878-1kt51viz	527	53	resulting	result	VBG
cord-280878-1kt51viz	527	54	from	from	IN
cord-280878-1kt51viz	527	55	expression	expression	NN
cord-280878-1kt51viz	527	56	of	of	IN
cord-280878-1kt51viz	527	57	influenza	influenza	NN
cord-280878-1kt51viz	527	58	-	-	HYPH
cord-280878-1kt51viz	527	59	virus	virus	NN
cord-280878-1kt51viz	527	60	M2	m2	NN
cord-280878-1kt51viz	527	61	protein	protein	NN
cord-280878-1kt51viz	527	62	in	in	IN
cord-280878-1kt51viz	527	63	Saccharomyces	Saccharomyces	NNP
cord-280878-1kt51viz	527	64	cerevisiae	cerevisiae	NNS
cord-280878-1kt51viz	527	65	:	:	:
cord-280878-1kt51viz	528	1	Identification	identification	NN
cord-280878-1kt51viz	528	2	of	of	IN
cord-280878-1kt51viz	528	3	a	a	DT
cord-280878-1kt51viz	528	4	novel	novel	JJ
cord-280878-1kt51viz	528	5	inhibitor	inhibitor	NN
cord-280878-1kt51viz	528	6	of	of	IN
cord-280878-1kt51viz	528	7	influenza	influenza	NN
cord-280878-1kt51viz	528	8	-	-	HYPH
cord-280878-1kt51viz	528	9	virus	virus	NN
cord-280878-1kt51viz	528	10	Anti	anti	JJ
cord-280878-1kt51viz	528	11	-	-	JJ
cord-280878-1kt51viz	528	12	influenza	influenza	JJ
cord-280878-1kt51viz	528	13	virus	virus	NN
cord-280878-1kt51viz	528	14	agents	agent	NNS
cord-280878-1kt51viz	528	15	:	:	:
cord-280878-1kt51viz	529	1	Synthesis	synthesis	NN
cord-280878-1kt51viz	529	2	and	and	CC
cord-280878-1kt51viz	529	3	mode	mode	NN
cord-280878-1kt51viz	529	4	of	of	IN
cord-280878-1kt51viz	529	5	action	action	NN
cord-280878-1kt51viz	529	6	Influenza	Influenza	NNP
cord-280878-1kt51viz	529	7	virus	virus	NN
cord-280878-1kt51viz	529	8	M2	M2	NNP
cord-280878-1kt51viz	529	9	protein	protein	NN
cord-280878-1kt51viz	529	10	is	be	VBZ
cord-280878-1kt51viz	529	11	an	an	DT
cord-280878-1kt51viz	529	12	integral	integral	JJ
cord-280878-1kt51viz	529	13	membrane	membrane	NN
cord-280878-1kt51viz	529	14	protein	protein	NN
cord-280878-1kt51viz	529	15	expressed	express	VBN
cord-280878-1kt51viz	529	16	on	on	IN
cord-280878-1kt51viz	529	17	the	the	DT
cord-280878-1kt51viz	529	18	infected	infect	VBN
cord-280878-1kt51viz	529	19	-	-	HYPH
cord-280878-1kt51viz	529	20	cell	cell	NN
cord-280878-1kt51viz	529	21	surface	surface	NN
cord-280878-1kt51viz	529	22	Peptides	peptide	NNS
cord-280878-1kt51viz	529	23	from	from	IN
cord-280878-1kt51viz	529	24	conserved	conserved	JJ
cord-280878-1kt51viz	529	25	regions	region	NNS
cord-280878-1kt51viz	529	26	of	of	IN
cord-280878-1kt51viz	529	27	paramyxovirus	paramyxovirus	JJ
cord-280878-1kt51viz	529	28	fusion	fusion	NN
cord-280878-1kt51viz	529	29	(	(	-LRB-
cord-280878-1kt51viz	529	30	F	F	NNP
cord-280878-1kt51viz	529	31	)	)	-RRB-
cord-280878-1kt51viz	529	32	proteins	protein	NNS
cord-280878-1kt51viz	529	33	are	be	VBP
cord-280878-1kt51viz	529	34	potent	potent	JJ
cord-280878-1kt51viz	529	35	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	529	36	of	of	IN
cord-280878-1kt51viz	529	37	viral	viral	JJ
cord-280878-1kt51viz	529	38	fusion	fusion	NN
cord-280878-1kt51viz	529	39	A	a	DT
cord-280878-1kt51viz	529	40	live	live	JJ
cord-280878-1kt51viz	529	41	attenuated	attenuated	JJ
cord-280878-1kt51viz	529	42	severe	severe	JJ
cord-280878-1kt51viz	529	43	acute	acute	JJ
cord-280878-1kt51viz	529	44	respiratory	respiratory	JJ
cord-280878-1kt51viz	529	45	syndrome	syndrome	NN
cord-280878-1kt51viz	529	46	coronavirus	coronavirus	NN
cord-280878-1kt51viz	529	47	is	be	VBZ
cord-280878-1kt51viz	529	48	immunogenic	immunogenic	JJ
cord-280878-1kt51viz	529	49	and	and	CC
cord-280878-1kt51viz	529	50	efficacious	efficacious	JJ
cord-280878-1kt51viz	529	51	in	in	IN
cord-280878-1kt51viz	529	52	golden	golden	JJ
cord-280878-1kt51viz	529	53	Syrian	syrian	JJ
cord-280878-1kt51viz	529	54	hamsters	hamster	NNS
cord-280878-1kt51viz	529	55	Genetic	genetic	JJ
cord-280878-1kt51viz	529	56	and	and	CC
cord-280878-1kt51viz	529	57	functional	functional	JJ
cord-280878-1kt51viz	529	58	heterogeneity	heterogeneity	NN
cord-280878-1kt51viz	529	59	of	of	IN
cord-280878-1kt51viz	529	60	the	the	DT
cord-280878-1kt51viz	529	61	hepatitis	hepatitis	NN
cord-280878-1kt51viz	529	62	C	C	NNP
cord-280878-1kt51viz	529	63	virus	virus	NN
cord-280878-1kt51viz	529	64	p7	p7	NN
cord-280878-1kt51viz	529	65	ion	ion	NN
cord-280878-1kt51viz	529	66	channel	channel	NN
cord-280878-1kt51viz	529	67	during	during	IN
cord-280878-1kt51viz	529	68	natural	natural	JJ
cord-280878-1kt51viz	529	69	chronic	chronic	JJ
cord-280878-1kt51viz	529	70	infection	infection	NN
cord-280878-1kt51viz	529	71	Interaction	Interaction	NNP
cord-280878-1kt51viz	529	72	between	between	IN
cord-280878-1kt51viz	529	73	human	human	JJ
cord-280878-1kt51viz	529	74	BAP31	BAP31	NNP
cord-280878-1kt51viz	529	75	and	and	CC
cord-280878-1kt51viz	529	76	respiratory	respiratory	JJ
cord-280878-1kt51viz	529	77	syncytial	syncytial	JJ
cord-280878-1kt51viz	529	78	virus	virus	NN
cord-280878-1kt51viz	529	79	small	small	JJ
cord-280878-1kt51viz	529	80	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	529	81	(	(	-LRB-
cord-280878-1kt51viz	529	82	SH	SH	NNP
cord-280878-1kt51viz	529	83	)	)	-RRB-
cord-280878-1kt51viz	529	84	protein	protein	NN
cord-280878-1kt51viz	529	85	Structure	Structure	NNP
cord-280878-1kt51viz	529	86	of	of	IN
cord-280878-1kt51viz	529	87	a	a	DT
cord-280878-1kt51viz	529	88	conserved	conserved	JJ
cord-280878-1kt51viz	529	89	Golgi	Golgi	NNP
cord-280878-1kt51viz	529	90	complextargeting	complextargete	VBG
cord-280878-1kt51viz	529	91	signal	signal	NN
cord-280878-1kt51viz	529	92	in	in	IN
cord-280878-1kt51viz	529	93	coronavirus	coronavirus	NN
cord-280878-1kt51viz	529	94	envelope	envelope	NN
cord-280878-1kt51viz	529	95	proteins	protein	NNS
cord-280878-1kt51viz	529	96	Inhibition	inhibition	NN
cord-280878-1kt51viz	529	97	of	of	IN
cord-280878-1kt51viz	529	98	the	the	DT
cord-280878-1kt51viz	529	99	human	human	JJ
cord-280878-1kt51viz	529	100	respiratory	respiratory	JJ
cord-280878-1kt51viz	529	101	syncytial	syncytial	JJ
cord-280878-1kt51viz	529	102	virus	virus	NN
cord-280878-1kt51viz	529	103	small	small	JJ
cord-280878-1kt51viz	529	104	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	529	105	protein	protein	NN
cord-280878-1kt51viz	529	106	and	and	CC
cord-280878-1kt51viz	529	107	structural	structural	JJ
cord-280878-1kt51viz	529	108	variations	variation	NNS
cord-280878-1kt51viz	529	109	in	in	IN
cord-280878-1kt51viz	529	110	a	a	DT
cord-280878-1kt51viz	529	111	bicelle	bicelle	NN
cord-280878-1kt51viz	529	112	environment	environment	NN
cord-280878-1kt51viz	529	113	Function	function	NN
cord-280878-1kt51viz	529	114	of	of	IN
cord-280878-1kt51viz	529	115	the	the	DT
cord-280878-1kt51viz	529	116	small	small	JJ
cord-280878-1kt51viz	529	117	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	529	118	protein	protein	NN
cord-280878-1kt51viz	529	119	of	of	IN
cord-280878-1kt51viz	529	120	J	J	NNP
cord-280878-1kt51viz	529	121	paramyxovirus	paramyxovirus	NNP
cord-280878-1kt51viz	529	122	Biochemical	biochemical	JJ
cord-280878-1kt51viz	529	123	and	and	CC
cord-280878-1kt51viz	529	124	functional	functional	JJ
cord-280878-1kt51viz	529	125	characterization	characterization	NN
cord-280878-1kt51viz	529	126	of	of	IN
cord-280878-1kt51viz	529	127	the	the	DT
cord-280878-1kt51viz	529	128	membrane	membrane	NN
cord-280878-1kt51viz	529	129	association	association	NNP
cord-280878-1kt51viz	529	130	and	and	CC
cord-280878-1kt51viz	529	131	membrane	membrane	NN
cord-280878-1kt51viz	529	132	permeabilizing	permeabilizing	NN
cord-280878-1kt51viz	529	133	activity	activity	NN
cord-280878-1kt51viz	529	134	of	of	IN
cord-280878-1kt51viz	529	135	the	the	DT
cord-280878-1kt51viz	529	136	severe	severe	JJ
cord-280878-1kt51viz	529	137	acute	acute	JJ
cord-280878-1kt51viz	529	138	respiratory	respiratory	JJ
cord-280878-1kt51viz	529	139	syndrome	syndrome	NN
cord-280878-1kt51viz	529	140	coronavirus	coronavirus	NN
cord-280878-1kt51viz	529	141	envelope	envelope	NN
cord-280878-1kt51viz	529	142	protein	protein	NN
cord-280878-1kt51viz	529	143	Internally	internally	RB
cord-280878-1kt51viz	529	144	located	locate	VBN
cord-280878-1kt51viz	529	145	cleavable	cleavable	JJ
cord-280878-1kt51viz	529	146	signal	signal	NN
cord-280878-1kt51viz	529	147	sequences	sequence	NNS
cord-280878-1kt51viz	529	148	direct	direct	VBP
cord-280878-1kt51viz	529	149	the	the	DT
cord-280878-1kt51viz	529	150	formation	formation	NN
cord-280878-1kt51viz	529	151	of	of	IN
cord-280878-1kt51viz	529	152	Semliki	Semliki	NNP
cord-280878-1kt51viz	529	153	Forest	Forest	NNP
cord-280878-1kt51viz	529	154	virus	virus	NN
cord-280878-1kt51viz	529	155	membrane	membrane	NN
cord-280878-1kt51viz	529	156	proteins	protein	NNS
cord-280878-1kt51viz	529	157	from	from	IN
cord-280878-1kt51viz	529	158	a	a	DT
cord-280878-1kt51viz	529	159	polyprotein	polyprotein	JJ
cord-280878-1kt51viz	529	160	precursor	precursor	NN
cord-280878-1kt51viz	530	1	In	in	IN
cord-280878-1kt51viz	530	2	vitro	vitro	FW
cord-280878-1kt51viz	530	3	mutagenesis	mutagenesis	NN
cord-280878-1kt51viz	530	4	of	of	IN
cord-280878-1kt51viz	530	5	a	a	DT
cord-280878-1kt51viz	530	6	fulllength	fulllength	NN
cord-280878-1kt51viz	530	7	cDNA	cdna	NN
cord-280878-1kt51viz	530	8	clone	clone	NN
cord-280878-1kt51viz	530	9	of	of	IN
cord-280878-1kt51viz	530	10	Semliki	Semliki	NNP
cord-280878-1kt51viz	530	11	Forest	Forest	NNP
cord-280878-1kt51viz	530	12	virus	virus	NN
cord-280878-1kt51viz	530	13	:	:	:
cord-280878-1kt51viz	530	14	The	the	DT
cord-280878-1kt51viz	530	15	small	small	JJ
cord-280878-1kt51viz	530	16	6,000-molecular	6,000-molecular	CD
cord-280878-1kt51viz	530	17	-	-	HYPH
cord-280878-1kt51viz	530	18	weight	weight	NN
cord-280878-1kt51viz	530	19	membrane	membrane	NN
cord-280878-1kt51viz	530	20	protein	protein	NN
cord-280878-1kt51viz	530	21	modulates	modulate	VBZ
cord-280878-1kt51viz	530	22	virus	virus	NN
cord-280878-1kt51viz	530	23	release	release	NN
cord-280878-1kt51viz	531	1	The	the	DT
cord-280878-1kt51viz	531	2	missing	missing	JJ
cord-280878-1kt51viz	531	3	link	link	NN
cord-280878-1kt51viz	531	4	in	in	IN
cord-280878-1kt51viz	531	5	coronavirus	coronavirus	NN
cord-280878-1kt51viz	531	6	assembly	assembly	NN
cord-280878-1kt51viz	531	7	.	.	.
cord-280878-1kt51viz	532	1	Retention	retention	NN
cord-280878-1kt51viz	532	2	of	of	IN
cord-280878-1kt51viz	532	3	the	the	DT
cord-280878-1kt51viz	532	4	avian	avian	JJ
cord-280878-1kt51viz	532	5	coronavirus	coronavirus	NN
cord-280878-1kt51viz	532	6	infectious	infectious	JJ
cord-280878-1kt51viz	532	7	bronchitis	bronchitis	NN
cord-280878-1kt51viz	532	8	virus	virus	NN
cord-280878-1kt51viz	532	9	envelope	envelope	NN
cord-280878-1kt51viz	532	10	protein	protein	NN
cord-280878-1kt51viz	532	11	in	in	IN
cord-280878-1kt51viz	532	12	the	the	DT
cord-280878-1kt51viz	532	13	pre	pre	JJ
cord-280878-1kt51viz	532	14	-	-	JJ
cord-280878-1kt51viz	532	15	Golgi	golgi	JJ
cord-280878-1kt51viz	532	16	compartments	compartment	NNS
cord-280878-1kt51viz	532	17	and	and	CC
cord-280878-1kt51viz	532	18	physical	physical	JJ
cord-280878-1kt51viz	532	19	interaction	interaction	NN
cord-280878-1kt51viz	532	20	between	between	IN
cord-280878-1kt51viz	532	21	the	the	DT
cord-280878-1kt51viz	532	22	envelope	envelope	NN
cord-280878-1kt51viz	532	23	and	and	CC
cord-280878-1kt51viz	532	24	membrane	membrane	NN
cord-280878-1kt51viz	532	25	proteins	protein	NNS
cord-280878-1kt51viz	532	26	Induction	Induction	NNP
cord-280878-1kt51viz	532	27	of	of	IN
cord-280878-1kt51viz	532	28	apoptosis	apoptosis	NN
cord-280878-1kt51viz	532	29	by	by	IN
cord-280878-1kt51viz	532	30	paramyxovirus	paramyxovirus	JJ
cord-280878-1kt51viz	532	31	simian	simian	JJ
cord-280878-1kt51viz	532	32	virus	virus	NN
cord-280878-1kt51viz	532	33	5	5	CD
cord-280878-1kt51viz	532	34	lacking	lack	VBG
cord-280878-1kt51viz	532	35	a	a	DT
cord-280878-1kt51viz	532	36	small	small	JJ
cord-280878-1kt51viz	532	37	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	532	38	gene	gene	NN
cord-280878-1kt51viz	532	39	Processing	processing	NN
cord-280878-1kt51viz	532	40	in	in	IN
cord-280878-1kt51viz	532	41	the	the	DT
cord-280878-1kt51viz	532	42	hepatitis	hepatitis	NN
cord-280878-1kt51viz	532	43	C	C	NNP
cord-280878-1kt51viz	532	44	virus	virus	NN
cord-280878-1kt51viz	532	45	E2-NS2	E2-NS2	NNP
cord-280878-1kt51viz	532	46	region	region	NN
cord-280878-1kt51viz	532	47	:	:	:
cord-280878-1kt51viz	532	48	Identification	identification	NN
cord-280878-1kt51viz	532	49	of	of	IN
cord-280878-1kt51viz	532	50	p7	p7	NN
cord-280878-1kt51viz	532	51	and	and	CC
cord-280878-1kt51viz	532	52	two	two	CD
cord-280878-1kt51viz	532	53	distinct	distinct	JJ
cord-280878-1kt51viz	532	54	E2-specific	E2-specific	NNS
cord-280878-1kt51viz	532	55	products	product	NNS
cord-280878-1kt51viz	532	56	with	with	IN
cord-280878-1kt51viz	532	57	different	different	JJ
cord-280878-1kt51viz	532	58	C	c	NN
cord-280878-1kt51viz	532	59	termini	termini	NN
cord-280878-1kt51viz	532	60	Unravelling	unravel	VBG
cord-280878-1kt51viz	532	61	hepatitis	hepatitis	NN
cord-280878-1kt51viz	532	62	C	c	NN
cord-280878-1kt51viz	532	63	virus	virus	NN
cord-280878-1kt51viz	532	64	replication	replication	NN
cord-280878-1kt51viz	532	65	from	from	IN
cord-280878-1kt51viz	532	66	genome	genome	NN
cord-280878-1kt51viz	532	67	to	to	TO
cord-280878-1kt51viz	532	68	function	function	VB
cord-280878-1kt51viz	533	1	The	the	DT
cord-280878-1kt51viz	533	2	6-kilodalton	6-kilodalton	CD
cord-280878-1kt51viz	533	3	membrane	membrane	NN
cord-280878-1kt51viz	533	4	protein	protein	NN
cord-280878-1kt51viz	533	5	of	of	IN
cord-280878-1kt51viz	533	6	Semliki	Semliki	NNP
cord-280878-1kt51viz	533	7	Forest	Forest	NNP
cord-280878-1kt51viz	533	8	virus	virus	NN
cord-280878-1kt51viz	533	9	is	be	VBZ
cord-280878-1kt51viz	533	10	involved	involve	VBN
cord-280878-1kt51viz	533	11	in	in	IN
cord-280878-1kt51viz	533	12	the	the	DT
cord-280878-1kt51viz	533	13	budding	budding	NN
cord-280878-1kt51viz	533	14	process	process	NN
cord-280878-1kt51viz	533	15	Replication	Replication	NNP
cord-280878-1kt51viz	533	16	of	of	IN
cord-280878-1kt51viz	533	17	subgenomic	subgenomic	NNP
cord-280878-1kt51viz	533	18	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	533	19	C	C	NNP
cord-280878-1kt51viz	533	20	virus	virus	NN
cord-280878-1kt51viz	533	21	RNAs	rna	NNS
cord-280878-1kt51viz	533	22	in	in	IN
cord-280878-1kt51viz	533	23	a	a	DT
cord-280878-1kt51viz	533	24	hepatoma	hepatoma	NNP
cord-280878-1kt51viz	533	25	cell	cell	NN
cord-280878-1kt51viz	533	26	line	line	NN
cord-280878-1kt51viz	533	27	Importance	importance	NN
cord-280878-1kt51viz	533	28	of	of	IN
cord-280878-1kt51viz	533	29	conserved	conserve	VBN
cord-280878-1kt51viz	533	30	cysteine	cysteine	NN
cord-280878-1kt51viz	533	31	residues	residue	NNS
cord-280878-1kt51viz	533	32	in	in	IN
cord-280878-1kt51viz	533	33	the	the	DT
cord-280878-1kt51viz	533	34	coronavirus	coronavirus	NN
cord-280878-1kt51viz	533	35	envelope	envelope	NN
cord-280878-1kt51viz	533	36	protein	protein	NN
cord-280878-1kt51viz	533	37	Current	current	JJ
cord-280878-1kt51viz	533	38	progress	progress	NN
cord-280878-1kt51viz	533	39	in	in	IN
cord-280878-1kt51viz	533	40	antiviral	antiviral	JJ
cord-280878-1kt51viz	533	41	strategies	strategy	NNS
cord-280878-1kt51viz	534	1	The	the	DT
cord-280878-1kt51viz	534	2	RSV	RSV	NNP
cord-280878-1kt51viz	534	3	F	F	NNP
cord-280878-1kt51viz	534	4	and	and	CC
cord-280878-1kt51viz	534	5	G	g	NN
cord-280878-1kt51viz	534	6	glycoproteins	glycoprotein	NNS
cord-280878-1kt51viz	534	7	interact	interact	VBP
cord-280878-1kt51viz	534	8	to	to	TO
cord-280878-1kt51viz	534	9	form	form	VB
cord-280878-1kt51viz	534	10	a	a	DT
cord-280878-1kt51viz	534	11	complex	complex	NN
cord-280878-1kt51viz	534	12	on	on	IN
cord-280878-1kt51viz	534	13	the	the	DT
cord-280878-1kt51viz	534	14	surface	surface	NN
cord-280878-1kt51viz	534	15	of	of	IN
cord-280878-1kt51viz	534	16	infected	infected	JJ
cord-280878-1kt51viz	534	17	cells	cell	NNS
cord-280878-1kt51viz	534	18	Oligomerization	Oligomerization	NNP
cord-280878-1kt51viz	534	19	state	state	NN
cord-280878-1kt51viz	534	20	and	and	CC
cord-280878-1kt51viz	534	21	supramolecular	supramolecular	JJ
cord-280878-1kt51viz	534	22	structure	structure	NN
cord-280878-1kt51viz	534	23	of	of	IN
cord-280878-1kt51viz	534	24	the	the	DT
cord-280878-1kt51viz	534	25	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	534	26	Vpu	Vpu	NNP
cord-280878-1kt51viz	534	27	protein	protein	NN
cord-280878-1kt51viz	534	28	transmembrane	transmembrane	NN
cord-280878-1kt51viz	534	29	segment	segment	NN
cord-280878-1kt51viz	534	30	in	in	IN
cord-280878-1kt51viz	534	31	phospholipid	phospholipid	NN
cord-280878-1kt51viz	534	32	bilayers	bilayer	NNS
cord-280878-1kt51viz	535	1	Severe	severe	JJ
cord-280878-1kt51viz	535	2	acute	acute	JJ
cord-280878-1kt51viz	535	3	respiratory	respiratory	JJ
cord-280878-1kt51viz	535	4	syndrome	syndrome	NN
cord-280878-1kt51viz	535	5	-	-	HYPH
cord-280878-1kt51viz	535	6	associated	associate	VBN
cord-280878-1kt51viz	535	7	coronavirus	coronavirus	NN
cord-280878-1kt51viz	535	8	3a	3a	CD
cord-280878-1kt51viz	535	9	protein	protein	NN
cord-280878-1kt51viz	535	10	forms	form	VBZ
cord-280878-1kt51viz	535	11	an	an	DT
cord-280878-1kt51viz	535	12	ion	ion	NN
cord-280878-1kt51viz	535	13	channel	channel	NN
cord-280878-1kt51viz	535	14	and	and	CC
cord-280878-1kt51viz	535	15	modulates	modulate	VBZ
cord-280878-1kt51viz	535	16	virus	virus	NN
cord-280878-1kt51viz	535	17	release	release	NN
cord-280878-1kt51viz	536	1	The	the	DT
cord-280878-1kt51viz	536	2	3-dimensional	3-dimensional	CD
cord-280878-1kt51viz	536	3	structure	structure	NN
cord-280878-1kt51viz	536	4	of	of	IN
cord-280878-1kt51viz	536	5	a	a	DT
cord-280878-1kt51viz	536	6	hepatitis	hepatitis	NN
cord-280878-1kt51viz	536	7	C	c	NN
cord-280878-1kt51viz	536	8	virus	virus	NN
cord-280878-1kt51viz	536	9	p7	p7	NN
cord-280878-1kt51viz	536	10	ion	ion	NN
cord-280878-1kt51viz	536	11	channel	channel	NN
cord-280878-1kt51viz	536	12	by	by	IN
cord-280878-1kt51viz	536	13	electron	electron	NN
cord-280878-1kt51viz	536	14	microscopy	microscopy	NNP
cord-280878-1kt51viz	537	1	A	a	DT
cord-280878-1kt51viz	537	2	novel	novel	JJ
cord-280878-1kt51viz	537	3	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	537	4	C	C	NNP
cord-280878-1kt51viz	537	5	virus	virus	NN
cord-280878-1kt51viz	537	6	p7	p7	NN
cord-280878-1kt51viz	537	7	ion	ion	NN
cord-280878-1kt51viz	537	8	channel	channel	NN
cord-280878-1kt51viz	537	9	inhibitor	inhibitor	NN
cord-280878-1kt51viz	537	10	,	,	,
cord-280878-1kt51viz	537	11	BIT225	BIT225	NNP
cord-280878-1kt51viz	537	12	,	,	,
cord-280878-1kt51viz	537	13	inhibits	inhibit	VBZ
cord-280878-1kt51viz	537	14	bovine	bovine	JJ
cord-280878-1kt51viz	537	15	viral	viral	JJ
cord-280878-1kt51viz	537	16	diarrhea	diarrhea	NN
cord-280878-1kt51viz	537	17	virus	virus	NN
cord-280878-1kt51viz	537	18	in	in	IN
cord-280878-1kt51viz	537	19	vitro	vitro	FW
cord-280878-1kt51viz	537	20	and	and	CC
cord-280878-1kt51viz	537	21	shows	show	VBZ
cord-280878-1kt51viz	537	22	synergism	synergism	NN
cord-280878-1kt51viz	537	23	with	with	IN
cord-280878-1kt51viz	537	24	recombinant	recombinant	JJ
cord-280878-1kt51viz	537	25	interferon	interferon	NN
cord-280878-1kt51viz	537	26	-	-	HYPH
cord-280878-1kt51viz	537	27	α-2b	α-2b	NN
cord-280878-1kt51viz	537	28	and	and	CC
cord-280878-1kt51viz	537	29	nucleoside	nucleoside	JJ
cord-280878-1kt51viz	537	30	analogues	analogue	NNS
cord-280878-1kt51viz	537	31	Structural	structural	JJ
cord-280878-1kt51viz	537	32	and	and	CC
cord-280878-1kt51viz	537	33	functional	functional	JJ
cord-280878-1kt51viz	537	34	properties	property	NNS
cord-280878-1kt51viz	537	35	of	of	IN
cord-280878-1kt51viz	537	36	the	the	DT
cord-280878-1kt51viz	537	37	hepatitis	hepatitis	NN
cord-280878-1kt51viz	537	38	C	C	NNP
cord-280878-1kt51viz	537	39	virus	virus	NN
cord-280878-1kt51viz	537	40	p7	p7	RB
cord-280878-1kt51viz	537	41	viroporin	viroporin	VBD
cord-280878-1kt51viz	537	42	Transmembrane	Transmembrane	NNP
cord-280878-1kt51viz	537	43	domain	domain	NN
cord-280878-1kt51viz	537	44	determinants	determinant	NNS
cord-280878-1kt51viz	537	45	of	of	IN
cord-280878-1kt51viz	537	46	CD4	CD4	NNP
cord-280878-1kt51viz	537	47	downregulation	downregulation	NN
cord-280878-1kt51viz	537	48	by	by	IN
cord-280878-1kt51viz	537	49	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	537	50	Vpu	Vpu	NNP
cord-280878-1kt51viz	537	51	Human	Human	NNP
cord-280878-1kt51viz	537	52	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	537	53	virus	virus	NN
cord-280878-1kt51viz	537	54	type	type	NN
cord-280878-1kt51viz	537	55	1	1	CD
cord-280878-1kt51viz	537	56	Vpu	Vpu	NNP
cord-280878-1kt51viz	537	57	protein	protein	NN
cord-280878-1kt51viz	537	58	is	be	VBZ
cord-280878-1kt51viz	537	59	an	an	DT
cord-280878-1kt51viz	537	60	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	537	61	type	type	NN
cord-280878-1kt51viz	537	62	I	-PRON-	PRP
cord-280878-1kt51viz	537	63	integral	integral	JJ
cord-280878-1kt51viz	537	64	membrane	membrane	NN
cord-280878-1kt51viz	537	65	protein	protein	NN
cord-280878-1kt51viz	537	66	Treating	treat	VBG
cord-280878-1kt51viz	537	67	viral	viral	JJ
cord-280878-1kt51viz	537	68	hepatitis	hepatitis	NN
cord-280878-1kt51viz	537	69	C	c	NN
cord-280878-1kt51viz	537	70	:	:	:
cord-280878-1kt51viz	537	71	Efficacy	efficacy	NN
cord-280878-1kt51viz	537	72	,	,	,
cord-280878-1kt51viz	537	73	side	side	NN
cord-280878-1kt51viz	537	74	effects	effect	NNS
cord-280878-1kt51viz	537	75	,	,	,
cord-280878-1kt51viz	537	76	and	and	CC
cord-280878-1kt51viz	537	77	complications	complication	NNS
cord-280878-1kt51viz	538	1	Distinct	distinct	JJ
cord-280878-1kt51viz	538	2	domains	domain	NNS
cord-280878-1kt51viz	538	3	of	of	IN
cord-280878-1kt51viz	538	4	the	the	DT
cord-280878-1kt51viz	538	5	influenza	influenza	NN
cord-280878-1kt51viz	538	6	a	a	DT
cord-280878-1kt51viz	538	7	virus	virus	NN
cord-280878-1kt51viz	538	8	M2	m2	NN
cord-280878-1kt51viz	538	9	protein	protein	NN
cord-280878-1kt51viz	538	10	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	538	11	tail	tail	NN
cord-280878-1kt51viz	538	12	mediate	mediate	VBP
cord-280878-1kt51viz	538	13	binding	bind	VBG
cord-280878-1kt51viz	538	14	to	to	IN
cord-280878-1kt51viz	538	15	the	the	DT
cord-280878-1kt51viz	538	16	M1	M1	NNP
cord-280878-1kt51viz	538	17	protein	protein	NN
cord-280878-1kt51viz	538	18	and	and	CC
cord-280878-1kt51viz	538	19	facilitate	facilitate	VB
cord-280878-1kt51viz	538	20	infectious	infectious	JJ
cord-280878-1kt51viz	538	21	virus	virus	NN
cord-280878-1kt51viz	538	22	production	production	NN
cord-280878-1kt51viz	538	23	Structure	structure	NN
cord-280878-1kt51viz	538	24	-	-	HYPH
cord-280878-1kt51viz	538	25	based	base	VBN
cord-280878-1kt51viz	538	26	design	design	NN
cord-280878-1kt51viz	538	27	of	of	IN
cord-280878-1kt51viz	538	28	a	a	DT
cord-280878-1kt51viz	538	29	fusion	fusion	NN
cord-280878-1kt51viz	538	30	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	538	31	vaccine	vaccine	NN
cord-280878-1kt51viz	538	32	for	for	IN
cord-280878-1kt51viz	538	33	respiratory	respiratory	JJ
cord-280878-1kt51viz	538	34	syncytial	syncytial	JJ
cord-280878-1kt51viz	538	35	virus	virus	NN
cord-280878-1kt51viz	538	36	Structure	Structure	NNP
cord-280878-1kt51viz	538	37	of	of	IN
cord-280878-1kt51viz	538	38	RSV	RSV	NNP
cord-280878-1kt51viz	538	39	fusion	fusion	NN
cord-280878-1kt51viz	538	40	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	538	41	trimer	trimer	NN
cord-280878-1kt51viz	538	42	bound	bind	VBN
cord-280878-1kt51viz	538	43	to	to	IN
cord-280878-1kt51viz	538	44	a	a	DT
cord-280878-1kt51viz	538	45	prefusion	prefusion	NN
cord-280878-1kt51viz	538	46	-	-	HYPH
cord-280878-1kt51viz	538	47	specific	specific	JJ
cord-280878-1kt51viz	538	48	neutralizing	neutralize	VBG
cord-280878-1kt51viz	538	49	antibody	antibody	NN
cord-280878-1kt51viz	538	50	Vpu	Vpu	NNP
cord-280878-1kt51viz	538	51	binds	bind	VBZ
cord-280878-1kt51viz	538	52	directly	directly	RB
cord-280878-1kt51viz	538	53	to	to	IN
cord-280878-1kt51viz	538	54	tetherin	tetherin	NNP
cord-280878-1kt51viz	538	55	and	and	CC
cord-280878-1kt51viz	538	56	displaces	displace	VBZ
cord-280878-1kt51viz	538	57	it	-PRON-	PRP
cord-280878-1kt51viz	538	58	from	from	IN
cord-280878-1kt51viz	538	59	nascent	nascent	JJ
cord-280878-1kt51viz	538	60	virions	virion	NNS
cord-280878-1kt51viz	539	1	Alphavirus	Alphavirus	NNP
cord-280878-1kt51viz	539	2	6	6	CD
cord-280878-1kt51viz	539	3	K	k	NN
cord-280878-1kt51viz	539	4	proteins	protein	NNS
cord-280878-1kt51viz	539	5	form	form	VBP
cord-280878-1kt51viz	539	6	ion	ion	NN
cord-280878-1kt51viz	539	7	channels	channel	NNS
cord-280878-1kt51viz	539	8	Amino	amino	NN
cord-280878-1kt51viz	539	9	acid	acid	NN
cord-280878-1kt51viz	539	10	variations	variation	NNS
cord-280878-1kt51viz	539	11	in	in	IN
cord-280878-1kt51viz	539	12	hepatitis	hepatitis	NN
cord-280878-1kt51viz	539	13	C	C	NNP
cord-280878-1kt51viz	539	14	virus	virus	NN
cord-280878-1kt51viz	539	15	p7	p7	NN
cord-280878-1kt51viz	539	16	and	and	CC
cord-280878-1kt51viz	539	17	sensitivity	sensitivity	NN
cord-280878-1kt51viz	539	18	to	to	IN
cord-280878-1kt51viz	539	19	antiviral	antiviral	JJ
cord-280878-1kt51viz	539	20	combination	combination	NN
cord-280878-1kt51viz	539	21	therapy	therapy	NN
cord-280878-1kt51viz	539	22	with	with	IN
cord-280878-1kt51viz	539	23	amantadine	amantadine	NNP
cord-280878-1kt51viz	539	24	in	in	IN
cord-280878-1kt51viz	539	25	chronic	chronic	JJ
cord-280878-1kt51viz	539	26	hepatitis	hepatitis	NN
cord-280878-1kt51viz	539	27	C	C	NNP
cord-280878-1kt51viz	539	28	Vpu	Vpu	NNP
cord-280878-1kt51viz	539	29	enhances	enhance	VBZ
cord-280878-1kt51viz	539	30	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	539	31	virus	virus	NN
cord-280878-1kt51viz	539	32	release	release	NN
cord-280878-1kt51viz	539	33	in	in	IN
cord-280878-1kt51viz	539	34	the	the	DT
cord-280878-1kt51viz	539	35	absence	absence	NN
cord-280878-1kt51viz	539	36	of	of	IN
cord-280878-1kt51viz	539	37	Bst-2	Bst-2	NNP
cord-280878-1kt51viz	539	38	cell	cell	NN
cord-280878-1kt51viz	539	39	surface	surface	NN
cord-280878-1kt51viz	539	40	down	down	IN
cord-280878-1kt51viz	539	41	-	-	HYPH
cord-280878-1kt51viz	539	42	modulation	modulation	NN
cord-280878-1kt51viz	539	43	and	and	CC
cord-280878-1kt51viz	539	44	intracellular	intracellular	JJ
cord-280878-1kt51viz	539	45	depletion	depletion	NN
cord-280878-1kt51viz	540	1	Two	two	CD
cord-280878-1kt51viz	540	2	hepatitis	hepatitis	NN
cord-280878-1kt51viz	540	3	C	c	NN
cord-280878-1kt51viz	540	4	virus	virus	NN
cord-280878-1kt51viz	540	5	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	540	6	E2	E2	NNP
cord-280878-1kt51viz	540	7	products	product	NNS
cord-280878-1kt51viz	540	8	with	with	IN
cord-280878-1kt51viz	540	9	different	different	JJ
cord-280878-1kt51viz	540	10	C	c	NN
cord-280878-1kt51viz	540	11	termini	termini	NN
cord-280878-1kt51viz	540	12	The	the	DT
cord-280878-1kt51viz	540	13	annual	annual	JJ
cord-280878-1kt51viz	540	14	impact	impact	NN
cord-280878-1kt51viz	540	15	of	of	IN
cord-280878-1kt51viz	540	16	seasonal	seasonal	JJ
cord-280878-1kt51viz	540	17	influenza	influenza	NN
cord-280878-1kt51viz	540	18	in	in	IN
cord-280878-1kt51viz	540	19	the	the	DT
cord-280878-1kt51viz	540	20	US	US	NNP
cord-280878-1kt51viz	540	21	:	:	:
cord-280878-1kt51viz	541	1	Measuring	measure	VBG
cord-280878-1kt51viz	541	2	disease	disease	NN
cord-280878-1kt51viz	541	3	burden	burden	NN
cord-280878-1kt51viz	541	4	and	and	CC
cord-280878-1kt51viz	541	5	costs	cost	VBZ
cord-280878-1kt51viz	541	6	NMR	NMR	NNP
cord-280878-1kt51viz	541	7	structure	structure	NN
cord-280878-1kt51viz	541	8	and	and	CC
cord-280878-1kt51viz	541	9	ion	ion	NN
cord-280878-1kt51viz	541	10	channel	channel	NN
cord-280878-1kt51viz	541	11	activity	activity	NN
cord-280878-1kt51viz	541	12	of	of	IN
cord-280878-1kt51viz	541	13	the	the	DT
cord-280878-1kt51viz	541	14	p7	p7	NN
cord-280878-1kt51viz	541	15	protein	protein	NN
cord-280878-1kt51viz	541	16	from	from	IN
cord-280878-1kt51viz	541	17	hepatitis	hepatitis	NN
cord-280878-1kt51viz	541	18	C	C	NNP
cord-280878-1kt51viz	541	19	virus	virus	NN
cord-280878-1kt51viz	541	20	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	541	21	C	C	NNP
cord-280878-1kt51viz	541	22	virus	virus	NN
cord-280878-1kt51viz	541	23	proteins	protein	NNS
cord-280878-1kt51viz	541	24	:	:	:
cord-280878-1kt51viz	541	25	From	from	IN
cord-280878-1kt51viz	541	26	structure	structure	NN
cord-280878-1kt51viz	541	27	to	to	TO
cord-280878-1kt51viz	541	28	function	function	VB
cord-280878-1kt51viz	542	1	Influenza	Influenza	NNP
cord-280878-1kt51viz	542	2	B	B	NNP
cord-280878-1kt51viz	542	3	virus	virus	NN
cord-280878-1kt51viz	542	4	BM2	BM2	NNP
cord-280878-1kt51viz	542	5	protein	protein	NN
cord-280878-1kt51viz	542	6	has	have	VBZ
cord-280878-1kt51viz	542	7	ion	ion	NN
cord-280878-1kt51viz	542	8	channel	channel	NN
cord-280878-1kt51viz	542	9	activity	activity	NN
cord-280878-1kt51viz	542	10	that	that	WDT
cord-280878-1kt51viz	542	11	conducts	conduct	VBZ
cord-280878-1kt51viz	542	12	protons	proton	NNS
cord-280878-1kt51viz	542	13	across	across	IN
cord-280878-1kt51viz	542	14	membranes	membrane	NNS
cord-280878-1kt51viz	542	15	Global	global	JJ
cord-280878-1kt51viz	542	16	burden	burden	NN
cord-280878-1kt51viz	542	17	of	of	IN
cord-280878-1kt51viz	542	18	acute	acute	JJ
cord-280878-1kt51viz	542	19	lower	low	JJR
cord-280878-1kt51viz	542	20	respiratory	respiratory	JJ
cord-280878-1kt51viz	542	21	infections	infection	NNS
cord-280878-1kt51viz	542	22	due	due	JJ
cord-280878-1kt51viz	542	23	to	to	IN
cord-280878-1kt51viz	542	24	respiratory	respiratory	JJ
cord-280878-1kt51viz	542	25	syncytial	syncytial	JJ
cord-280878-1kt51viz	542	26	virus	virus	NN
cord-280878-1kt51viz	542	27	in	in	IN
cord-280878-1kt51viz	542	28	young	young	JJ
cord-280878-1kt51viz	542	29	children	child	NNS
cord-280878-1kt51viz	542	30	:	:	:
cord-280878-1kt51viz	543	1	A	a	DT
cord-280878-1kt51viz	543	2	systematic	systematic	JJ
cord-280878-1kt51viz	543	3	review	review	NN
cord-280878-1kt51viz	543	4	and	and	CC
cord-280878-1kt51viz	543	5	meta	meta	NNP
cord-280878-1kt51viz	543	6	-	-	HYPH
cord-280878-1kt51viz	543	7	analysis	analysis	NN
cord-280878-1kt51viz	544	1	Tetherin	Tetherin	NNP
cord-280878-1kt51viz	544	2	inhibits	inhibit	VBZ
cord-280878-1kt51viz	544	3	retrovirus	retrovirus	NN
cord-280878-1kt51viz	544	4	release	release	NN
cord-280878-1kt51viz	544	5	and	and	CC
cord-280878-1kt51viz	544	6	is	be	VBZ
cord-280878-1kt51viz	544	7	antagonized	antagonize	VBN
cord-280878-1kt51viz	544	8	by	by	IN
cord-280878-1kt51viz	544	9	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	544	10	Vpu	Vpu	NNP
cord-280878-1kt51viz	544	11	Immunization	Immunization	NNP
cord-280878-1kt51viz	544	12	with	with	IN
cord-280878-1kt51viz	544	13	an	an	DT
cord-280878-1kt51viz	544	14	attenuated	attenuated	JJ
cord-280878-1kt51viz	544	15	severe	severe	JJ
cord-280878-1kt51viz	544	16	acute	acute	JJ
cord-280878-1kt51viz	544	17	respiratory	respiratory	JJ
cord-280878-1kt51viz	544	18	syndrome	syndrome	NN
cord-280878-1kt51viz	544	19	coronavirus	coronavirus	NN
cord-280878-1kt51viz	544	20	deleted	delete	VBN
cord-280878-1kt51viz	544	21	in	in	IN
cord-280878-1kt51viz	544	22	E	e	NN
cord-280878-1kt51viz	544	23	protein	protein	NN
cord-280878-1kt51viz	544	24	protects	protect	VBZ
cord-280878-1kt51viz	544	25	against	against	IN
cord-280878-1kt51viz	544	26	lethal	lethal	JJ
cord-280878-1kt51viz	544	27	respiratory	respiratory	JJ
cord-280878-1kt51viz	544	28	disease	disease	NN
cord-280878-1kt51viz	544	29	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	544	30	C	C	NNP
cord-280878-1kt51viz	544	31	viral	viral	JJ
cord-280878-1kt51viz	544	32	dynamics	dynamic	NNS
cord-280878-1kt51viz	544	33	in	in	IN
cord-280878-1kt51viz	544	34	vivo	vivo	NN
cord-280878-1kt51viz	544	35	and	and	CC
cord-280878-1kt51viz	544	36	the	the	DT
cord-280878-1kt51viz	544	37	antiviral	antiviral	JJ
cord-280878-1kt51viz	544	38	efficacy	efficacy	NN
cord-280878-1kt51viz	544	39	of	of	IN
cord-280878-1kt51viz	544	40	interferon	interferon	NN
cord-280878-1kt51viz	544	41	-	-	HYPH
cord-280878-1kt51viz	544	42	alpha	alpha	NN
cord-280878-1kt51viz	544	43	therapy	therapy	NN
cord-280878-1kt51viz	544	44	Emergence	emergence	NN
cord-280878-1kt51viz	544	45	and	and	CC
cord-280878-1kt51viz	544	46	pandemic	pandemic	NN
cord-280878-1kt51viz	544	47	potential	potential	NN
cord-280878-1kt51viz	544	48	of	of	IN
cord-280878-1kt51viz	544	49	swine	swine	NN
cord-280878-1kt51viz	544	50	-	-	HYPH
cord-280878-1kt51viz	544	51	origin	origin	NN
cord-280878-1kt51viz	544	52	H1N1	H1N1	NNP
cord-280878-1kt51viz	544	53	influenza	influenza	NN
cord-280878-1kt51viz	544	54	virus	virus	NN
cord-280878-1kt51viz	544	55	Subcellular	Subcellular	NNP
cord-280878-1kt51viz	544	56	location	location	NN
cord-280878-1kt51viz	544	57	and	and	CC
cord-280878-1kt51viz	544	58	topology	topology	NN
cord-280878-1kt51viz	544	59	of	of	IN
cord-280878-1kt51viz	544	60	severe	severe	JJ
cord-280878-1kt51viz	544	61	acute	acute	JJ
cord-280878-1kt51viz	544	62	respiratory	respiratory	JJ
cord-280878-1kt51viz	544	63	syndrome	syndrome	NN
cord-280878-1kt51viz	544	64	coronavirus	coronavirus	NN
cord-280878-1kt51viz	544	65	envelope	envelope	NN
cord-280878-1kt51viz	544	66	protein	protein	NN
cord-280878-1kt51viz	544	67	Severe	severe	JJ
cord-280878-1kt51viz	544	68	acute	acute	JJ
cord-280878-1kt51viz	544	69	respiratory	respiratory	JJ
cord-280878-1kt51viz	544	70	syndrome	syndrome	NN
cord-280878-1kt51viz	544	71	coronavirus	coronavirus	NN
cord-280878-1kt51viz	544	72	envelope	envelope	NN
cord-280878-1kt51viz	544	73	protein	protein	NN
cord-280878-1kt51viz	544	74	ion	ion	NN
cord-280878-1kt51viz	544	75	channel	channel	NN
cord-280878-1kt51viz	544	76	activity	activity	NN
cord-280878-1kt51viz	544	77	promotes	promote	VBZ
cord-280878-1kt51viz	544	78	virus	virus	NN
cord-280878-1kt51viz	544	79	fitness	fitness	NN
cord-280878-1kt51viz	544	80	and	and	CC
cord-280878-1kt51viz	544	81	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	544	82	Relevance	relevance	NN
cord-280878-1kt51viz	544	83	of	of	IN
cord-280878-1kt51viz	544	84	viroporin	viroporin	NNP
cord-280878-1kt51viz	544	85	ion	ion	NN
cord-280878-1kt51viz	544	86	channel	channel	NN
cord-280878-1kt51viz	544	87	activity	activity	NN
cord-280878-1kt51viz	544	88	on	on	IN
cord-280878-1kt51viz	544	89	viral	viral	JJ
cord-280878-1kt51viz	544	90	replication	replication	NN
cord-280878-1kt51viz	544	91	and	and	CC
cord-280878-1kt51viz	544	92	pathogenesis	pathogenesis	NN
cord-280878-1kt51viz	544	93	Mechanisms	mechanism	NNS
cord-280878-1kt51viz	544	94	of	of	IN
cord-280878-1kt51viz	544	95	membrane	membrane	NN
cord-280878-1kt51viz	544	96	permeabilization	permeabilization	NN
cord-280878-1kt51viz	544	97	by	by	IN
cord-280878-1kt51viz	544	98	picornavirus	picornavirus	NNP
cord-280878-1kt51viz	544	99	2B	2B	NNP
cord-280878-1kt51viz	544	100	viroporin	viroporin	NNP
cord-280878-1kt51viz	544	101	Viroporins	Viroporins	NNP
cord-280878-1kt51viz	544	102	:	:	:
cord-280878-1kt51viz	544	103	Structures	structure	NNS
cord-280878-1kt51viz	544	104	and	and	CC
cord-280878-1kt51viz	544	105	functions	function	NNS
cord-280878-1kt51viz	544	106	beyond	beyond	IN
cord-280878-1kt51viz	544	107	cell	cell	NN
cord-280878-1kt51viz	544	108	membrane	membrane	NN
cord-280878-1kt51viz	544	109	permeabilization	permeabilization	NN
cord-280878-1kt51viz	544	110	Viroporins	Viroporins	NNP
cord-280878-1kt51viz	544	111	:	:	:
cord-280878-1kt51viz	544	112	Structure	structure	NN
cord-280878-1kt51viz	544	113	and	and	CC
cord-280878-1kt51viz	544	114	biological	biological	JJ
cord-280878-1kt51viz	544	115	functions	function	NNS
cord-280878-1kt51viz	545	1	Relating	relate	VBG
cord-280878-1kt51viz	545	2	structure	structure	NN
cord-280878-1kt51viz	545	3	and	and	CC
cord-280878-1kt51viz	545	4	function	function	NN
cord-280878-1kt51viz	545	5	of	of	IN
cord-280878-1kt51viz	545	6	viral	viral	JJ
cord-280878-1kt51viz	545	7	membrane	membrane	NN
cord-280878-1kt51viz	545	8	-	-	HYPH
cord-280878-1kt51viz	545	9	spanning	span	VBG
cord-280878-1kt51viz	545	10	miniproteins	miniprotein	NNS
cord-280878-1kt51viz	545	11	Unusual	unusual	JJ
cord-280878-1kt51viz	545	12	architecture	architecture	NN
cord-280878-1kt51viz	545	13	of	of	IN
cord-280878-1kt51viz	545	14	the	the	DT
cord-280878-1kt51viz	545	15	p7	p7	NN
cord-280878-1kt51viz	545	16	channel	channel	NN
cord-280878-1kt51viz	545	17	from	from	IN
cord-280878-1kt51viz	545	18	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	545	19	C	C	NNP
cord-280878-1kt51viz	545	20	virus	virus	NN
cord-280878-1kt51viz	545	21	Expression	expression	NN
cord-280878-1kt51viz	545	22	and	and	CC
cord-280878-1kt51viz	545	23	purification	purification	NN
cord-280878-1kt51viz	545	24	of	of	IN
cord-280878-1kt51viz	545	25	coronavirus	coronavirus	NN
cord-280878-1kt51viz	545	26	envelope	envelope	NN
cord-280878-1kt51viz	545	27	proteins	protein	NNS
cord-280878-1kt51viz	545	28	using	use	VBG
cord-280878-1kt51viz	545	29	a	a	DT
cord-280878-1kt51viz	545	30	modified	modify	VBN
cord-280878-1kt51viz	545	31	beta	beta	NN
cord-280878-1kt51viz	545	32	-	-	HYPH
cord-280878-1kt51viz	545	33	barrel	barrel	NN
cord-280878-1kt51viz	545	34	construct	construct	NN
cord-280878-1kt51viz	545	35	Structural	structural	JJ
cord-280878-1kt51viz	545	36	flexibility	flexibility	NN
cord-280878-1kt51viz	545	37	of	of	IN
cord-280878-1kt51viz	545	38	the	the	DT
cord-280878-1kt51viz	545	39	pentameric	pentameric	NN
cord-280878-1kt51viz	545	40	SARS	SARS	NNP
cord-280878-1kt51viz	545	41	coronavirus	coronavirus	NN
cord-280878-1kt51viz	545	42	envelope	envelope	NN
cord-280878-1kt51viz	545	43	protein	protein	NN
cord-280878-1kt51viz	545	44	ion	ion	NN
cord-280878-1kt51viz	545	45	channel	channel	NN
cord-280878-1kt51viz	545	46	A	a	DT
cord-280878-1kt51viz	545	47	RhoA	RhoA	NNP
cord-280878-1kt51viz	545	48	-	-	HYPH
cord-280878-1kt51viz	545	49	derived	derive	VBN
cord-280878-1kt51viz	545	50	peptide	peptide	NN
cord-280878-1kt51viz	545	51	inhibits	inhibit	VBZ
cord-280878-1kt51viz	545	52	syncytium	syncytium	NN
cord-280878-1kt51viz	545	53	formation	formation	NN
cord-280878-1kt51viz	545	54	induced	induce	VBN
cord-280878-1kt51viz	545	55	by	by	IN
cord-280878-1kt51viz	545	56	respiratory	respiratory	JJ
cord-280878-1kt51viz	545	57	syncytial	syncytial	JJ
cord-280878-1kt51viz	545	58	virus	virus	NN
cord-280878-1kt51viz	545	59	and	and	CC
cord-280878-1kt51viz	545	60	parainfluenza	parainfluenza	NNP
cord-280878-1kt51viz	545	61	virus	virus	NNP
cord-280878-1kt51viz	545	62	type	type	NN
cord-280878-1kt51viz	545	63	3	3	CD
cord-280878-1kt51viz	545	64	Protein	protein	NN
cord-280878-1kt51viz	545	65	-	-	HYPH
cord-280878-1kt51viz	545	66	protein	protein	NN
cord-280878-1kt51viz	545	67	interactions	interaction	NNS
cord-280878-1kt51viz	545	68	:	:	:
cord-280878-1kt51viz	545	69	Modeling	model	VBG
cord-280878-1kt51viz	545	70	the	the	DT
cord-280878-1kt51viz	545	71	hepatitis	hepatitis	NN
cord-280878-1kt51viz	545	72	C	C	NNP
cord-280878-1kt51viz	545	73	virus	virus	NN
cord-280878-1kt51viz	545	74	ion	ion	NN
cord-280878-1kt51viz	545	75	channel	channel	NN
cord-280878-1kt51viz	545	76	p7	p7	NN
cord-280878-1kt51viz	545	77	Influenza	Influenza	NNP
cord-280878-1kt51viz	545	78	B	B	NNP
cord-280878-1kt51viz	545	79	virus	virus	NN
cord-280878-1kt51viz	545	80	BM2	BM2	NNP
cord-280878-1kt51viz	545	81	protein	protein	NN
cord-280878-1kt51viz	545	82	is	be	VBZ
cord-280878-1kt51viz	545	83	an	an	DT
cord-280878-1kt51viz	545	84	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	545	85	integral	integral	JJ
cord-280878-1kt51viz	545	86	membrane	membrane	NN
cord-280878-1kt51viz	545	87	protein	protein	NN
cord-280878-1kt51viz	545	88	expressed	express	VBN
cord-280878-1kt51viz	545	89	at	at	IN
cord-280878-1kt51viz	545	90	the	the	DT
cord-280878-1kt51viz	545	91	cell	cell	NN
cord-280878-1kt51viz	545	92	surface	surface	NN
cord-280878-1kt51viz	545	93	The	the	DT
cord-280878-1kt51viz	545	94	hepatitis	hepatitis	NN
cord-280878-1kt51viz	545	95	C	c	NN
cord-280878-1kt51viz	545	96	virus	virus	NN
cord-280878-1kt51viz	545	97	p7	p7	NN
cord-280878-1kt51viz	545	98	protein	protein	NN
cord-280878-1kt51viz	545	99	forms	form	VBZ
cord-280878-1kt51viz	545	100	an	an	DT
cord-280878-1kt51viz	545	101	ion	ion	NN
cord-280878-1kt51viz	545	102	channel	channel	NN
cord-280878-1kt51viz	545	103	that	that	WDT
cord-280878-1kt51viz	545	104	is	be	VBZ
cord-280878-1kt51viz	545	105	inhibited	inhibit	VBN
cord-280878-1kt51viz	545	106	by	by	IN
cord-280878-1kt51viz	545	107	long	long	JJ
cord-280878-1kt51viz	545	108	-	-	HYPH
cord-280878-1kt51viz	545	109	alkyl	alkyl	NN
cord-280878-1kt51viz	545	110	-	-	HYPH
cord-280878-1kt51viz	545	111	chain	chain	NN
cord-280878-1kt51viz	545	112	iminosugar	iminosugar	NN
cord-280878-1kt51viz	545	113	derivatives	derivative	NNS
cord-280878-1kt51viz	545	114	New	New	NNP
cord-280878-1kt51viz	545	115	hepatitis	hepatitis	NN
cord-280878-1kt51viz	545	116	C	c	NN
cord-280878-1kt51viz	545	117	therapies	therapy	NNS
cord-280878-1kt51viz	545	118	:	:	:
cord-280878-1kt51viz	545	119	The	the	DT
cord-280878-1kt51viz	545	120	toolbox	toolbox	NN
cord-280878-1kt51viz	545	121	,	,	,
cord-280878-1kt51viz	545	122	strategies	strategy	NNS
cord-280878-1kt51viz	545	123	,	,	,
cord-280878-1kt51viz	545	124	and	and	CC
cord-280878-1kt51viz	545	125	challenges	challenge	VBZ
cord-280878-1kt51viz	545	126	The	the	DT
cord-280878-1kt51viz	545	127	hepatitis	hepatitis	NN
cord-280878-1kt51viz	545	128	C	c	NN
cord-280878-1kt51viz	545	129	virus	virus	NN
cord-280878-1kt51viz	545	130	life	life	NN
cord-280878-1kt51viz	545	131	cycle	cycle	NN
cord-280878-1kt51viz	545	132	as	as	IN
cord-280878-1kt51viz	545	133	a	a	DT
cord-280878-1kt51viz	545	134	target	target	NN
cord-280878-1kt51viz	545	135	for	for	IN
cord-280878-1kt51viz	545	136	new	new	JJ
cord-280878-1kt51viz	545	137	antiviral	antiviral	JJ
cord-280878-1kt51viz	545	138	therapies	therapy	NNS
cord-280878-1kt51viz	545	139	Structure	Structure	NNP
cord-280878-1kt51viz	545	140	and	and	CC
cord-280878-1kt51viz	545	141	inhibition	inhibition	NN
cord-280878-1kt51viz	545	142	of	of	IN
cord-280878-1kt51viz	545	143	the	the	DT
cord-280878-1kt51viz	545	144	SARS	SARS	NNP
cord-280878-1kt51viz	545	145	coronavirus	coronavirus	NN
cord-280878-1kt51viz	545	146	envelope	envelope	NN
cord-280878-1kt51viz	545	147	protein	protein	NN
cord-280878-1kt51viz	545	148	ion	ion	NN
cord-280878-1kt51viz	545	149	channel	channel	NN
cord-280878-1kt51viz	545	150	Influenza	Influenza	NNP
cord-280878-1kt51viz	545	151	M2	M2	NNP
cord-280878-1kt51viz	545	152	proton	proton	NN
cord-280878-1kt51viz	545	153	channels	channel	NNS
cord-280878-1kt51viz	545	154	Structural	structural	JJ
cord-280878-1kt51viz	545	155	investigation	investigation	NN
cord-280878-1kt51viz	545	156	of	of	IN
cord-280878-1kt51viz	545	157	rimantadine	rimantadine	JJ
cord-280878-1kt51viz	545	158	inhibition	inhibition	NN
cord-280878-1kt51viz	545	159	of	of	IN
cord-280878-1kt51viz	545	160	the	the	DT
cord-280878-1kt51viz	545	161	AM2-BM2	AM2-BM2	NNP
cord-280878-1kt51viz	545	162	chimera	chimera	NN
cord-280878-1kt51viz	545	163	channel	channel	NN
cord-280878-1kt51viz	545	164	of	of	IN
cord-280878-1kt51viz	545	165	influenza	influenza	NN
cord-280878-1kt51viz	545	166	viruses	virus	NNS
cord-280878-1kt51viz	545	167	Mechanism	Mechanism	NNP
cord-280878-1kt51viz	545	168	of	of	IN
cord-280878-1kt51viz	545	169	drug	drug	NN
cord-280878-1kt51viz	545	170	inhibition	inhibition	NN
cord-280878-1kt51viz	545	171	and	and	CC
cord-280878-1kt51viz	545	172	drug	drug	NN
cord-280878-1kt51viz	545	173	resistance	resistance	NN
cord-280878-1kt51viz	545	174	of	of	IN
cord-280878-1kt51viz	545	175	influenza	influenza	NN
cord-280878-1kt51viz	545	176	A	a	DT
cord-280878-1kt51viz	545	177	M2	m2	JJ
cord-280878-1kt51viz	545	178	channel	channel	NN
cord-280878-1kt51viz	545	179	Construction	construction	NN
cord-280878-1kt51viz	545	180	and	and	CC
cord-280878-1kt51viz	545	181	characterization	characterization	NN
cord-280878-1kt51viz	545	182	of	of	IN
cord-280878-1kt51viz	545	183	infectious	infectious	JJ
cord-280878-1kt51viz	545	184	intragenotypic	intragenotypic	NNP
cord-280878-1kt51viz	545	185	and	and	CC
cord-280878-1kt51viz	545	186	intergenotypic	intergenotypic	NNP
cord-280878-1kt51viz	545	187	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	545	188	C	C	NNP
cord-280878-1kt51viz	545	189	virus	virus	NN
cord-280878-1kt51viz	546	1	chimeras	chimera	NNS
cord-280878-1kt51viz	546	2	Influenza	Influenza	NNP
cord-280878-1kt51viz	546	3	virus	virus	NN
cord-280878-1kt51viz	546	4	M2	m2	NN
cord-280878-1kt51viz	546	5	protein	protein	NN
cord-280878-1kt51viz	546	6	has	have	VBZ
cord-280878-1kt51viz	546	7	ion	ion	NN
cord-280878-1kt51viz	546	8	channel	channel	NN
cord-280878-1kt51viz	546	9	activity	activity	NN
cord-280878-1kt51viz	547	1	The	the	DT
cord-280878-1kt51viz	547	2	M2	m2	JJ
cord-280878-1kt51viz	547	3	proton	proton	NN
cord-280878-1kt51viz	547	4	channels	channel	NNS
cord-280878-1kt51viz	547	5	of	of	IN
cord-280878-1kt51viz	547	6	influenza	influenza	NN
cord-280878-1kt51viz	547	7	A	a	NN
cord-280878-1kt51viz	547	8	and	and	CC
cord-280878-1kt51viz	547	9	B	b	NN
cord-280878-1kt51viz	547	10	viruses	virus	NNS
cord-280878-1kt51viz	548	1	Combined	combined	JJ
cord-280878-1kt51viz	548	2	transport	transport	NN
cord-280878-1kt51viz	548	3	of	of	IN
cord-280878-1kt51viz	548	4	water	water	NN
cord-280878-1kt51viz	548	5	and	and	CC
cord-280878-1kt51viz	548	6	ions	ion	NNS
cord-280878-1kt51viz	548	7	through	through	IN
cord-280878-1kt51viz	548	8	membrane	membrane	NN
cord-280878-1kt51viz	548	9	channels	channel	NNS
cord-280878-1kt51viz	549	1	Cation	cation	NN
cord-280878-1kt51viz	549	2	-	-	HYPH
cord-280878-1kt51viz	549	3	selective	selective	JJ
cord-280878-1kt51viz	549	4	ion	ion	NN
cord-280878-1kt51viz	549	5	channels	channel	NNS
cord-280878-1kt51viz	549	6	formed	form	VBN
cord-280878-1kt51viz	549	7	by	by	IN
cord-280878-1kt51viz	549	8	p7	p7	RB
cord-280878-1kt51viz	549	9	of	of	IN
cord-280878-1kt51viz	549	10	hepatitis	hepatitis	NN
cord-280878-1kt51viz	549	11	C	C	NNP
cord-280878-1kt51viz	549	12	virus	virus	NN
cord-280878-1kt51viz	549	13	are	be	VBP
cord-280878-1kt51viz	549	14	blocked	block	VBN
cord-280878-1kt51viz	549	15	by	by	IN
cord-280878-1kt51viz	549	16	hexamethylene	hexamethylene	NNP
cord-280878-1kt51viz	549	17	amiloride	amiloride	NNP
cord-280878-1kt51viz	549	18	Characterization	Characterization	NNP
cord-280878-1kt51viz	549	19	of	of	IN
cord-280878-1kt51viz	549	20	the	the	DT
cord-280878-1kt51viz	549	21	coronavirus	coronavirus	NN
cord-280878-1kt51viz	549	22	mouse	mouse	NN
cord-280878-1kt51viz	549	23	hepatitis	hepatitis	NN
cord-280878-1kt51viz	549	24	virus	virus	NN
cord-280878-1kt51viz	549	25	strain	strain	VBP
cord-280878-1kt51viz	549	26	A59	A59	NNP
cord-280878-1kt51viz	549	27	small	small	JJ
cord-280878-1kt51viz	549	28	membrane	membrane	NN
cord-280878-1kt51viz	549	29	protein	protein	NN
cord-280878-1kt51viz	549	30	E	e	NN
cord-280878-1kt51viz	549	31	NMR	NMR	NNP
cord-280878-1kt51viz	549	32	structures	structure	NNS
cord-280878-1kt51viz	549	33	of	of	IN
cord-280878-1kt51viz	549	34	membrane	membrane	NN
cord-280878-1kt51viz	549	35	proteins	protein	NNS
cord-280878-1kt51viz	549	36	in	in	IN
cord-280878-1kt51viz	549	37	phospholipid	phospholipid	NN
cord-280878-1kt51viz	549	38	bilayers	bilayer	NNS
cord-280878-1kt51viz	549	39	MERS	MERS	NNP
cord-280878-1kt51viz	549	40	:	:	:
cord-280878-1kt51viz	550	1	Emergence	emergence	NN
cord-280878-1kt51viz	550	2	of	of	IN
cord-280878-1kt51viz	550	3	a	a	DT
cord-280878-1kt51viz	550	4	novel	novel	JJ
cord-280878-1kt51viz	550	5	human	human	JJ
cord-280878-1kt51viz	550	6	coronavirus	coronavirus	NN
cord-280878-1kt51viz	550	7	.	.	.
cord-280878-1kt51viz	551	1	Current	current	JJ
cord-280878-1kt51viz	551	2	Opinion	opinion	NN
cord-280878-1kt51viz	551	3	in	in	IN
cord-280878-1kt51viz	551	4	Virology	Virology	NNP
cord-280878-1kt51viz	551	5	RFI-641	RFI-641	NNP
cord-280878-1kt51viz	551	6	inhibits	inhibit	VBZ
cord-280878-1kt51viz	551	7	entry	entry	NN
cord-280878-1kt51viz	551	8	of	of	IN
cord-280878-1kt51viz	551	9	respiratory	respiratory	JJ
cord-280878-1kt51viz	551	10	syncytial	syncytial	JJ
cord-280878-1kt51viz	551	11	virus	virus	NN
cord-280878-1kt51viz	551	12	via	via	IN
cord-280878-1kt51viz	551	13	interactions	interaction	NNS
cord-280878-1kt51viz	551	14	with	with	IN
cord-280878-1kt51viz	551	15	fusion	fusion	NN
cord-280878-1kt51viz	551	16	protein	protein	NN
cord-280878-1kt51viz	551	17	Bap31	Bap31	NNP
cord-280878-1kt51viz	551	18	is	be	VBZ
cord-280878-1kt51viz	551	19	a	a	DT
cord-280878-1kt51viz	551	20	novel	novel	JJ
cord-280878-1kt51viz	551	21	target	target	NN
cord-280878-1kt51viz	551	22	of	of	IN
cord-280878-1kt51viz	551	23	the	the	DT
cord-280878-1kt51viz	551	24	human	human	JJ
cord-280878-1kt51viz	551	25	papillomavirus	papillomavirus	NN
cord-280878-1kt51viz	551	26	E5	e5	NN
cord-280878-1kt51viz	551	27	protein	protein	NN
cord-280878-1kt51viz	551	28	Easily	easily	RB
cord-280878-1kt51viz	551	29	accessible	accessible	JJ
cord-280878-1kt51viz	551	30	polycyclic	polycyclic	JJ
cord-280878-1kt51viz	551	31	amines	amine	NNS
cord-280878-1kt51viz	551	32	that	that	WDT
cord-280878-1kt51viz	551	33	inhibit	inhibit	VBP
cord-280878-1kt51viz	551	34	the	the	DT
cord-280878-1kt51viz	551	35	wild	wild	JJ
cord-280878-1kt51viz	551	36	-	-	HYPH
cord-280878-1kt51viz	551	37	type	type	NN
cord-280878-1kt51viz	551	38	and	and	CC
cord-280878-1kt51viz	551	39	amantadine	amantadine	NN
cord-280878-1kt51viz	551	40	-	-	HYPH
cord-280878-1kt51viz	551	41	resistant	resistant	JJ
cord-280878-1kt51viz	551	42	mutants	mutant	NNS
cord-280878-1kt51viz	551	43	of	of	IN
cord-280878-1kt51viz	551	44	the	the	DT
cord-280878-1kt51viz	551	45	M2	M2	NNP
cord-280878-1kt51viz	551	46	channel	channel	NN
cord-280878-1kt51viz	551	47	of	of	IN
cord-280878-1kt51viz	551	48	influenza	influenza	NN
cord-280878-1kt51viz	551	49	A	a	DT
cord-280878-1kt51viz	551	50	virus	virus	NN
cord-280878-1kt51viz	551	51	3-azatetracyclo[5.2.1.15,8.01,5]undecane	3-azatetracyclo[5.2.1.15,8.01,5]undecane	CD
cord-280878-1kt51viz	551	52	derivatives	derivative	NNS
cord-280878-1kt51viz	551	53	:	:	:
cord-280878-1kt51viz	551	54	From	from	IN
cord-280878-1kt51viz	551	55	wild	wild	JJ
cord-280878-1kt51viz	551	56	-	-	HYPH
cord-280878-1kt51viz	551	57	type	type	NN
cord-280878-1kt51viz	551	58	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	551	59	of	of	IN
cord-280878-1kt51viz	551	60	the	the	DT
cord-280878-1kt51viz	551	61	M2	M2	NNP
cord-280878-1kt51viz	551	62	ion	ion	NN
cord-280878-1kt51viz	551	63	channel	channel	NN
cord-280878-1kt51viz	551	64	of	of	IN
cord-280878-1kt51viz	551	65	influenza	influenza	NN
cord-280878-1kt51viz	551	66	A	a	DT
cord-280878-1kt51viz	551	67	virus	virus	NN
cord-280878-1kt51viz	551	68	to	to	IN
cord-280878-1kt51viz	551	69	derivatives	derivative	NNS
cord-280878-1kt51viz	551	70	with	with	IN
cord-280878-1kt51viz	551	71	potent	potent	JJ
cord-280878-1kt51viz	551	72	activity	activity	NN
cord-280878-1kt51viz	551	73	against	against	IN
cord-280878-1kt51viz	551	74	the	the	DT
cord-280878-1kt51viz	551	75	V27A	V27A	NNP
cord-280878-1kt51viz	551	76	mutant	mutant	JJ
cord-280878-1kt51viz	552	1	The	the	DT
cord-280878-1kt51viz	552	2	small	small	JJ
cord-280878-1kt51viz	552	3	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	552	4	(	(	-LRB-
cord-280878-1kt51viz	552	5	SH	sh	NN
cord-280878-1kt51viz	552	6	)	)	-RRB-
cord-280878-1kt51viz	552	7	protein	protein	NN
cord-280878-1kt51viz	552	8	accumulates	accumulate	VBZ
cord-280878-1kt51viz	552	9	within	within	IN
cord-280878-1kt51viz	552	10	lipid	lipid	NN
cord-280878-1kt51viz	552	11	-	-	HYPH
cord-280878-1kt51viz	552	12	raft	raft	NN
cord-280878-1kt51viz	552	13	structures	structure	NNS
cord-280878-1kt51viz	552	14	of	of	IN
cord-280878-1kt51viz	552	15	the	the	DT
cord-280878-1kt51viz	552	16	Golgi	Golgi	NNP
cord-280878-1kt51viz	552	17	complex	complex	NN
cord-280878-1kt51viz	552	18	during	during	IN
cord-280878-1kt51viz	552	19	respiratory	respiratory	JJ
cord-280878-1kt51viz	552	20	syncytial	syncytial	JJ
cord-280878-1kt51viz	552	21	virus	virus	NN
cord-280878-1kt51viz	552	22	infection	infection	NN
cord-280878-1kt51viz	553	1	The	the	DT
cord-280878-1kt51viz	553	2	respiratory	respiratory	JJ
cord-280878-1kt51viz	553	3	syncytial	syncytial	JJ
cord-280878-1kt51viz	553	4	virus	virus	NN
cord-280878-1kt51viz	553	5	small	small	JJ
cord-280878-1kt51viz	553	6	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	553	7	protein	protein	NN
cord-280878-1kt51viz	553	8	is	be	VBZ
cord-280878-1kt51viz	553	9	phosphorylated	phosphorylate	VBN
cord-280878-1kt51viz	553	10	via	via	IN
cord-280878-1kt51viz	553	11	a	a	DT
cord-280878-1kt51viz	553	12	mitogen	mitogen	NN
cord-280878-1kt51viz	553	13	-	-	HYPH
cord-280878-1kt51viz	553	14	activated	activate	VBN
cord-280878-1kt51viz	553	15	protein	protein	NN
cord-280878-1kt51viz	553	16	kinase	kinase	NN
cord-280878-1kt51viz	553	17	p38-dependent	p38-dependent	JJ
cord-280878-1kt51viz	553	18	tyrosine	tyrosine	NN
cord-280878-1kt51viz	553	19	kinase	kinase	NN
cord-280878-1kt51viz	553	20	activity	activity	NN
cord-280878-1kt51viz	553	21	during	during	IN
cord-280878-1kt51viz	553	22	virus	virus	NN
cord-280878-1kt51viz	553	23	infection	infection	NN
cord-280878-1kt51viz	553	24	Binding	Binding	NNP
cord-280878-1kt51viz	553	25	of	of	IN
cord-280878-1kt51viz	553	26	a	a	DT
cord-280878-1kt51viz	553	27	potent	potent	JJ
cord-280878-1kt51viz	553	28	small	small	JJ
cord-280878-1kt51viz	553	29	-	-	HYPH
cord-280878-1kt51viz	553	30	molecule	molecule	NN
cord-280878-1kt51viz	553	31	inhibitor	inhibitor	NN
cord-280878-1kt51viz	553	32	of	of	IN
cord-280878-1kt51viz	553	33	six	six	CD
cord-280878-1kt51viz	553	34	-	-	HYPH
cord-280878-1kt51viz	553	35	helix	helix	NN
cord-280878-1kt51viz	553	36	bundle	bundle	NN
cord-280878-1kt51viz	553	37	formation	formation	NN
cord-280878-1kt51viz	553	38	requires	require	VBZ
cord-280878-1kt51viz	553	39	interactions	interaction	NNS
cord-280878-1kt51viz	553	40	with	with	IN
cord-280878-1kt51viz	553	41	both	both	DT
cord-280878-1kt51viz	553	42	heptad	heptad	NN
cord-280878-1kt51viz	553	43	-	-	HYPH
cord-280878-1kt51viz	553	44	repeats	repeat	NNS
cord-280878-1kt51viz	553	45	of	of	IN
cord-280878-1kt51viz	553	46	the	the	DT
cord-280878-1kt51viz	553	47	RSV	RSV	NNP
cord-280878-1kt51viz	553	48	fusion	fusion	NN
cord-280878-1kt51viz	553	49	protein	protein	NN
cord-280878-1kt51viz	553	50	A	a	DT
cord-280878-1kt51viz	553	51	single	single	JJ
cord-280878-1kt51viz	553	52	polar	polar	JJ
cord-280878-1kt51viz	553	53	residue	residue	NN
cord-280878-1kt51viz	553	54	and	and	CC
cord-280878-1kt51viz	553	55	distinct	distinct	JJ
cord-280878-1kt51viz	553	56	membrane	membrane	NN
cord-280878-1kt51viz	553	57	topologies	topology	NNS
cord-280878-1kt51viz	553	58	impact	impact	VBP
cord-280878-1kt51viz	553	59	the	the	DT
cord-280878-1kt51viz	553	60	function	function	NN
cord-280878-1kt51viz	553	61	of	of	IN
cord-280878-1kt51viz	553	62	the	the	DT
cord-280878-1kt51viz	553	63	infectious	infectious	JJ
cord-280878-1kt51viz	553	64	bronchitis	bronchitis	NN
cord-280878-1kt51viz	553	65	coronavirus	coronavirus	NN
cord-280878-1kt51viz	553	66	E	e	NN
cord-280878-1kt51viz	553	67	protein	protein	NN
cord-280878-1kt51viz	553	68	The	the	DT
cord-280878-1kt51viz	553	69	active	active	JJ
cord-280878-1kt51viz	553	70	oligomeric	oligomeric	JJ
cord-280878-1kt51viz	553	71	state	state	NN
cord-280878-1kt51viz	553	72	of	of	IN
cord-280878-1kt51viz	553	73	the	the	DT
cord-280878-1kt51viz	553	74	minimalistic	minimalistic	JJ
cord-280878-1kt51viz	553	75	influenza	influenza	NN
cord-280878-1kt51viz	553	76	virus	virus	NN
cord-280878-1kt51viz	553	77	M-2	M-2	NNP
cord-280878-1kt51viz	553	78	ion	ion	NN
cord-280878-1kt51viz	553	79	channel	channel	NN
cord-280878-1kt51viz	553	80	is	be	VBZ
cord-280878-1kt51viz	553	81	a	a	DT
cord-280878-1kt51viz	553	82	tetramer	tetramer	NN
cord-280878-1kt51viz	554	1	The	the	DT
cord-280878-1kt51viz	554	2	p7	p7	NN
cord-280878-1kt51viz	554	3	polypeptide	polypeptide	NN
cord-280878-1kt51viz	554	4	of	of	IN
cord-280878-1kt51viz	554	5	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	554	6	C	C	NNP
cord-280878-1kt51viz	554	7	virus	virus	NN
cord-280878-1kt51viz	554	8	is	be	VBZ
cord-280878-1kt51viz	554	9	critical	critical	JJ
cord-280878-1kt51viz	554	10	for	for	IN
cord-280878-1kt51viz	554	11	infectivity	infectivity	NN
cord-280878-1kt51viz	554	12	and	and	CC
cord-280878-1kt51viz	554	13	contains	contain	VBZ
cord-280878-1kt51viz	554	14	functionally	functionally	RB
cord-280878-1kt51viz	554	15	important	important	JJ
cord-280878-1kt51viz	554	16	genotype	genotype	NN
cord-280878-1kt51viz	554	17	-	-	HYPH
cord-280878-1kt51viz	554	18	specific	specific	JJ
cord-280878-1kt51viz	554	19	sequences	sequence	NNS
cord-280878-1kt51viz	554	20	Triatoma	Triatoma	NNP
cord-280878-1kt51viz	554	21	virus	virus	NN
cord-280878-1kt51viz	554	22	recombinant	recombinant	JJ
cord-280878-1kt51viz	554	23	VP4	VP4	NNP
cord-280878-1kt51viz	554	24	protein	protein	NN
cord-280878-1kt51viz	554	25	induces	induce	VBZ
cord-280878-1kt51viz	554	26	membrane	membrane	NN
cord-280878-1kt51viz	554	27	permeability	permeability	NN
cord-280878-1kt51viz	554	28	through	through	IN
cord-280878-1kt51viz	554	29	dynamic	dynamic	JJ
cord-280878-1kt51viz	554	30	pores	pore	NNS
cord-280878-1kt51viz	554	31	Semliki	Semliki	NNP
cord-280878-1kt51viz	554	32	Forest	Forest	NNP
cord-280878-1kt51viz	554	33	virus	virus	NN
cord-280878-1kt51viz	554	34	6	6	CD
cord-280878-1kt51viz	554	35	K	K	NNP
cord-280878-1kt51viz	554	36	protein	protein	NN
cord-280878-1kt51viz	554	37	modifies	modify	VBZ
cord-280878-1kt51viz	554	38	membrane	membrane	NN
cord-280878-1kt51viz	554	39	permeability	permeability	NN
cord-280878-1kt51viz	554	40	after	after	IN
cord-280878-1kt51viz	554	41	inducible	inducible	JJ
cord-280878-1kt51viz	554	42	expression	expression	NN
cord-280878-1kt51viz	554	43	in	in	IN
cord-280878-1kt51viz	554	44	Escherichia	Escherichia	NNP
cord-280878-1kt51viz	554	45	coli	coli	NNS
cord-280878-1kt51viz	554	46	cells	cell	NNS
cord-280878-1kt51viz	554	47	Essential	essential	JJ
cord-280878-1kt51viz	554	48	roles	role	NNS
cord-280878-1kt51viz	554	49	of	of	IN
cord-280878-1kt51viz	554	50	Leu	Leu	NNP
cord-280878-1kt51viz	554	51	/	/	SYM
cord-280878-1kt51viz	554	52	Ile	Ile	NNP
cord-280878-1kt51viz	554	53	/	/	SYM
cord-280878-1kt51viz	554	54	Phe	phe	NN
cord-280878-1kt51viz	554	55	-	-	HYPH
cord-280878-1kt51viz	554	56	rich	rich	JJ
cord-280878-1kt51viz	554	57	domain	domain	NN
cord-280878-1kt51viz	554	58	of	of	IN
cord-280878-1kt51viz	554	59	JC	JC	NNP
cord-280878-1kt51viz	554	60	virus	virus	NN
cord-280878-1kt51viz	554	61	agnoprotein	agnoprotein	RB
cord-280878-1kt51viz	554	62	in	in	IN
cord-280878-1kt51viz	554	63	dimer/	dimer/	NNP
cord-280878-1kt51viz	554	64	oligomer	oligomer	NNP
cord-280878-1kt51viz	554	65	formation	formation	NN
cord-280878-1kt51viz	554	66	,	,	,
cord-280878-1kt51viz	554	67	protein	protein	NN
cord-280878-1kt51viz	554	68	stability	stability	NN
cord-280878-1kt51viz	554	69	and	and	CC
cord-280878-1kt51viz	554	70	splicing	splicing	NN
cord-280878-1kt51viz	554	71	of	of	IN
cord-280878-1kt51viz	554	72	viral	viral	JJ
cord-280878-1kt51viz	554	73	transcripts	transcript	NNS
cord-280878-1kt51viz	554	74	Infection	infection	NN
cord-280878-1kt51viz	554	75	by	by	IN
cord-280878-1kt51viz	554	76	agnoproteinnegative	agnoproteinnegative	JJ
cord-280878-1kt51viz	554	77	mutants	mutant	NNS
cord-280878-1kt51viz	554	78	of	of	IN
cord-280878-1kt51viz	554	79	polyomavirus	polyomavirus	NNP
cord-280878-1kt51viz	554	80	JC	JC	NNP
cord-280878-1kt51viz	554	81	and	and	CC
cord-280878-1kt51viz	554	82	SV40	SV40	NNP
cord-280878-1kt51viz	554	83	results	result	VBZ
cord-280878-1kt51viz	554	84	in	in	IN
cord-280878-1kt51viz	554	85	the	the	DT
cord-280878-1kt51viz	554	86	release	release	NN
cord-280878-1kt51viz	554	87	of	of	IN
cord-280878-1kt51viz	554	88	virions	virion	NNS
cord-280878-1kt51viz	554	89	that	that	WDT
cord-280878-1kt51viz	554	90	are	be	VBP
cord-280878-1kt51viz	554	91	mostly	mostly	RB
cord-280878-1kt51viz	554	92	deficient	deficient	JJ
cord-280878-1kt51viz	554	93	in	in	IN
cord-280878-1kt51viz	554	94	DNA	dna	NN
cord-280878-1kt51viz	554	95	content	content	NN
cord-280878-1kt51viz	554	96	Protection	protection	NN
cord-280878-1kt51viz	554	97	and	and	CC
cord-280878-1kt51viz	554	98	mechanism	mechanism	NN
cord-280878-1kt51viz	554	99	of	of	IN
cord-280878-1kt51viz	554	100	action	action	NN
cord-280878-1kt51viz	554	101	of	of	IN
cord-280878-1kt51viz	554	102	a	a	DT
cord-280878-1kt51viz	554	103	novel	novel	JJ
cord-280878-1kt51viz	554	104	human	human	JJ
cord-280878-1kt51viz	554	105	respiratory	respiratory	JJ
cord-280878-1kt51viz	554	106	syncytial	syncytial	JJ
cord-280878-1kt51viz	554	107	virus	virus	NN
cord-280878-1kt51viz	554	108	vaccine	vaccine	NN
cord-280878-1kt51viz	554	109	candidate	candidate	NN
cord-280878-1kt51viz	554	110	based	base	VBN
cord-280878-1kt51viz	554	111	on	on	IN
cord-280878-1kt51viz	554	112	the	the	DT
cord-280878-1kt51viz	554	113	extracellular	extracellular	JJ
cord-280878-1kt51viz	554	114	domain	domain	NN
cord-280878-1kt51viz	554	115	of	of	IN
cord-280878-1kt51viz	554	116	small	small	JJ
cord-280878-1kt51viz	554	117	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	554	118	protein	protein	NN
cord-280878-1kt51viz	554	119	Direct	Direct	NNP
cord-280878-1kt51viz	554	120	-	-	HYPH
cord-280878-1kt51viz	554	121	acting	act	VBG
cord-280878-1kt51viz	554	122	antiviral	antiviral	JJ
cord-280878-1kt51viz	554	123	agents	agent	NNS
cord-280878-1kt51viz	554	124	and	and	CC
cord-280878-1kt51viz	554	125	the	the	DT
cord-280878-1kt51viz	554	126	path	path	NN
cord-280878-1kt51viz	554	127	to	to	IN
cord-280878-1kt51viz	554	128	interferon	interferon	NN
cord-280878-1kt51viz	554	129	independence	independence	NN
cord-280878-1kt51viz	554	130	Structure	Structure	NNP
cord-280878-1kt51viz	554	131	and	and	CC
cord-280878-1kt51viz	554	132	mechanism	mechanism	NN
cord-280878-1kt51viz	554	133	of	of	IN
cord-280878-1kt51viz	554	134	the	the	DT
cord-280878-1kt51viz	554	135	M2	M2	NNP
cord-280878-1kt51viz	554	136	proton	proton	NN
cord-280878-1kt51viz	554	137	channel	channel	NN
cord-280878-1kt51viz	554	138	of	of	IN
cord-280878-1kt51viz	554	139	influenza	influenza	NN
cord-280878-1kt51viz	554	140	A	a	DT
cord-280878-1kt51viz	554	141	virus	virus	NN
cord-280878-1kt51viz	554	142	Identification	identification	NN
cord-280878-1kt51viz	554	143	of	of	IN
cord-280878-1kt51viz	554	144	an	an	DT
cord-280878-1kt51viz	554	145	ion	ion	NN
cord-280878-1kt51viz	554	146	channel	channel	NN
cord-280878-1kt51viz	554	147	activity	activity	NN
cord-280878-1kt51viz	554	148	of	of	IN
cord-280878-1kt51viz	554	149	the	the	DT
cord-280878-1kt51viz	554	150	Vpu	Vpu	NNP
cord-280878-1kt51viz	554	151	transmembrane	transmembrane	NN
cord-280878-1kt51viz	554	152	domain	domain	NN
cord-280878-1kt51viz	554	153	and	and	CC
cord-280878-1kt51viz	554	154	its	-PRON-	PRP$
cord-280878-1kt51viz	554	155	involvement	involvement	NN
cord-280878-1kt51viz	554	156	in	in	IN
cord-280878-1kt51viz	554	157	the	the	DT
cord-280878-1kt51viz	554	158	regulation	regulation	NN
cord-280878-1kt51viz	554	159	of	of	IN
cord-280878-1kt51viz	554	160	virus	virus	NN
cord-280878-1kt51viz	554	161	release	release	NN
cord-280878-1kt51viz	554	162	from	from	IN
cord-280878-1kt51viz	554	163	HIV-1-infected	hiv-1-infecte	VBN
cord-280878-1kt51viz	554	164	cells	cell	NNS
cord-280878-1kt51viz	554	165	Viroporins	viroporin	NNS
cord-280878-1kt51viz	554	166	:	:	:
cord-280878-1kt51viz	554	167	Structure	structure	NN
cord-280878-1kt51viz	554	168	,	,	,
cord-280878-1kt51viz	554	169	function	function	NN
cord-280878-1kt51viz	554	170	and	and	CC
cord-280878-1kt51viz	554	171	potential	potential	NN
cord-280878-1kt51viz	554	172	as	as	IN
cord-280878-1kt51viz	554	173	antiviral	antiviral	JJ
cord-280878-1kt51viz	554	174	targets	target	NNS
cord-280878-1kt51viz	554	175	TLR2	TLR2	NNP
cord-280878-1kt51viz	554	176	/	/	SYM
cord-280878-1kt51viz	554	177	MyD88	MyD88	NNP
cord-280878-1kt51viz	554	178	/	/	SYM
cord-280878-1kt51viz	554	179	NF	nf	NN
cord-280878-1kt51viz	554	180	-	-	HYPH
cord-280878-1kt51viz	554	181	kappa	kappa	NNP
cord-280878-1kt51viz	554	182	B	B	NNP
cord-280878-1kt51viz	554	183	pathway	pathway	NN
cord-280878-1kt51viz	554	184	,	,	,
cord-280878-1kt51viz	554	185	reactive	reactive	JJ
cord-280878-1kt51viz	554	186	oxygen	oxygen	NN
cord-280878-1kt51viz	554	187	species	specie	NNS
cord-280878-1kt51viz	554	188	,	,	,
cord-280878-1kt51viz	554	189	potassium	potassium	NN
cord-280878-1kt51viz	554	190	efflux	efflux	NN
cord-280878-1kt51viz	554	191	activates	activate	VBZ
cord-280878-1kt51viz	555	1	NLRP3	NLRP3	NNP
cord-280878-1kt51viz	555	2	/	/	SYM
cord-280878-1kt51viz	555	3	ASC	ASC	NNP
cord-280878-1kt51viz	555	4	inflammasome	inflammasome	NN
cord-280878-1kt51viz	555	5	during	during	IN
cord-280878-1kt51viz	555	6	respiratory	respiratory	JJ
cord-280878-1kt51viz	555	7	syncytial	syncytial	JJ
cord-280878-1kt51viz	555	8	virus	virus	NN
cord-280878-1kt51viz	555	9	infection	infection	NN
cord-280878-1kt51viz	555	10	Insight	Insight	NNP
cord-280878-1kt51viz	555	11	into	into	IN
cord-280878-1kt51viz	555	12	the	the	DT
cord-280878-1kt51viz	555	13	mechanism	mechanism	NN
cord-280878-1kt51viz	555	14	of	of	IN
cord-280878-1kt51viz	555	15	the	the	DT
cord-280878-1kt51viz	555	16	influenza	influenza	NN
cord-280878-1kt51viz	555	17	A	a	DT
cord-280878-1kt51viz	555	18	proton	proton	NN
cord-280878-1kt51viz	555	19	channel	channel	NN
cord-280878-1kt51viz	555	20	from	from	IN
cord-280878-1kt51viz	555	21	a	a	DT
cord-280878-1kt51viz	555	22	structure	structure	NN
cord-280878-1kt51viz	555	23	in	in	IN
cord-280878-1kt51viz	555	24	a	a	DT
cord-280878-1kt51viz	555	25	lipid	lipid	NN
cord-280878-1kt51viz	555	26	bilayer	bilayer	NN
cord-280878-1kt51viz	555	27	Modular	modular	JJ
cord-280878-1kt51viz	555	28	alpha	alpha	JJ
cord-280878-1kt51viz	555	29	-	-	HYPH
cord-280878-1kt51viz	555	30	helical	helical	JJ
cord-280878-1kt51viz	555	31	mimetics	mimetic	NNS
cord-280878-1kt51viz	555	32	with	with	IN
cord-280878-1kt51viz	555	33	antiviral	antiviral	JJ
cord-280878-1kt51viz	555	34	activity	activity	NN
cord-280878-1kt51viz	555	35	against	against	IN
cord-280878-1kt51viz	555	36	respiratory	respiratory	JJ
cord-280878-1kt51viz	555	37	syncitial	syncitial	JJ
cord-280878-1kt51viz	555	38	virus	virus	NN
cord-280878-1kt51viz	555	39	High	high	JJ
cord-280878-1kt51viz	555	40	frequency	frequency	NN
cord-280878-1kt51viz	555	41	of	of	IN
cord-280878-1kt51viz	555	42	resistant	resistant	JJ
cord-280878-1kt51viz	555	43	viruses	virus	NNS
cord-280878-1kt51viz	555	44	harboring	harbor	VBG
cord-280878-1kt51viz	555	45	different	different	JJ
cord-280878-1kt51viz	555	46	mutations	mutation	NNS
cord-280878-1kt51viz	555	47	in	in	IN
cord-280878-1kt51viz	555	48	amantadine	amantadine	NN
cord-280878-1kt51viz	555	49	-	-	HYPH
cord-280878-1kt51viz	555	50	treated	treat	VBN
cord-280878-1kt51viz	555	51	children	child	NNS
cord-280878-1kt51viz	555	52	with	with	IN
cord-280878-1kt51viz	555	53	influenza	influenza	NN
cord-280878-1kt51viz	556	1	The	the	DT
cord-280878-1kt51viz	556	2	origin	origin	NN
cord-280878-1kt51viz	556	3	of	of	IN
cord-280878-1kt51viz	556	4	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	556	5	C	C	NNP
cord-280878-1kt51viz	556	6	virus	virus	NN
cord-280878-1kt51viz	556	7	Mapping	map	VBG
cord-280878-1kt51viz	556	8	the	the	DT
cord-280878-1kt51viz	556	9	interaction	interaction	NN
cord-280878-1kt51viz	556	10	between	between	IN
cord-280878-1kt51viz	556	11	the	the	DT
cord-280878-1kt51viz	556	12	cytoplasmic	cytoplasmic	JJ
cord-280878-1kt51viz	556	13	domains	domain	NNS
cord-280878-1kt51viz	556	14	of	of	IN
cord-280878-1kt51viz	556	15	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	556	16	viral	viral	JJ
cord-280878-1kt51viz	556	17	protein	protein	NN
cord-280878-1kt51viz	556	18	U	u	NN
cord-280878-1kt51viz	556	19	and	and	CC
cord-280878-1kt51viz	556	20	human	human	JJ
cord-280878-1kt51viz	556	21	CD4	CD4	NNP
cord-280878-1kt51viz	556	22	with	with	IN
cord-280878-1kt51viz	556	23	NMR	NMR	NNP
cord-280878-1kt51viz	556	24	spectroscopy	spectroscopy	NN
cord-280878-1kt51viz	557	1	The	the	DT
cord-280878-1kt51viz	557	2	M	M	NNP
cord-280878-1kt51viz	557	3	,	,	,
cord-280878-1kt51viz	557	4	E	E	NNP
cord-280878-1kt51viz	557	5	,	,	,
cord-280878-1kt51viz	557	6	and	and	CC
cord-280878-1kt51viz	557	7	N	n	CD
cord-280878-1kt51viz	557	8	structural	structural	JJ
cord-280878-1kt51viz	557	9	proteins	protein	NNS
cord-280878-1kt51viz	557	10	of	of	IN
cord-280878-1kt51viz	557	11	the	the	DT
cord-280878-1kt51viz	557	12	severe	severe	JJ
cord-280878-1kt51viz	557	13	acute	acute	JJ
cord-280878-1kt51viz	557	14	respiratory	respiratory	JJ
cord-280878-1kt51viz	557	15	syndrome	syndrome	NN
cord-280878-1kt51viz	557	16	coronavirus	coronavirus	NN
cord-280878-1kt51viz	557	17	are	be	VBP
cord-280878-1kt51viz	557	18	required	require	VBN
cord-280878-1kt51viz	557	19	for	for	IN
cord-280878-1kt51viz	557	20	efficient	efficient	JJ
cord-280878-1kt51viz	557	21	assembly	assembly	NN
cord-280878-1kt51viz	557	22	,	,	,
cord-280878-1kt51viz	557	23	trafficking	trafficking	NN
cord-280878-1kt51viz	557	24	,	,	,
cord-280878-1kt51viz	557	25	and	and	CC
cord-280878-1kt51viz	557	26	release	release	NN
cord-280878-1kt51viz	557	27	of	of	IN
cord-280878-1kt51viz	557	28	virus	virus	NN
cord-280878-1kt51viz	557	29	-	-	HYPH
cord-280878-1kt51viz	557	30	like	like	JJ
cord-280878-1kt51viz	557	31	particles	particle	NNS
cord-280878-1kt51viz	557	32	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	557	33	Vpu	Vpu	NNP
cord-280878-1kt51viz	557	34	protein	protein	NN
cord-280878-1kt51viz	557	35	antagonizes	antagonize	VBZ
cord-280878-1kt51viz	557	36	innate	innate	JJ
cord-280878-1kt51viz	557	37	restriction	restriction	NN
cord-280878-1kt51viz	557	38	factor	factor	NN
cord-280878-1kt51viz	557	39	BST-2	BST-2	NNP
cord-280878-1kt51viz	557	40	via	via	IN
cord-280878-1kt51viz	557	41	lipid	lipid	NN
cord-280878-1kt51viz	557	42	-	-	HYPH
cord-280878-1kt51viz	557	43	embedded	embed	VBN
cord-280878-1kt51viz	557	44	helix	helix	NN
cord-280878-1kt51viz	557	45	-	-	HYPH
cord-280878-1kt51viz	557	46	helix	helix	NN
cord-280878-1kt51viz	557	47	interactions	interaction	NNS
cord-280878-1kt51viz	558	1	Exacerbated	exacerbate	VBN
cord-280878-1kt51viz	558	2	innate	innate	JJ
cord-280878-1kt51viz	558	3	host	host	NN
cord-280878-1kt51viz	558	4	response	response	NN
cord-280878-1kt51viz	558	5	to	to	IN
cord-280878-1kt51viz	558	6	SARS	SARS	NNP
cord-280878-1kt51viz	558	7	-	-	HYPH
cord-280878-1kt51viz	558	8	CoV	CoV	NNP
cord-280878-1kt51viz	558	9	in	in	IN
cord-280878-1kt51viz	558	10	aged	aged	JJ
cord-280878-1kt51viz	558	11	non	non	JJ
cord-280878-1kt51viz	558	12	-	-	JJ
cord-280878-1kt51viz	558	13	human	human	JJ
cord-280878-1kt51viz	558	14	primates	primate	NNS
cord-280878-1kt51viz	558	15	Hepatitis	Hepatitis	NNP
cord-280878-1kt51viz	558	16	C	C	NNP
cord-280878-1kt51viz	558	17	virus	virus	NN
cord-280878-1kt51viz	558	18	p7	p7	NN
cord-280878-1kt51viz	558	19	protein	protein	NN
cord-280878-1kt51viz	558	20	is	be	VBZ
cord-280878-1kt51viz	558	21	crucial	crucial	JJ
cord-280878-1kt51viz	558	22	for	for	IN
cord-280878-1kt51viz	558	23	assembly	assembly	NN
cord-280878-1kt51viz	558	24	and	and	CC
cord-280878-1kt51viz	558	25	release	release	NN
cord-280878-1kt51viz	558	26	of	of	IN
cord-280878-1kt51viz	558	27	infectious	infectious	JJ
cord-280878-1kt51viz	558	28	virions	virion	NNS
cord-280878-1kt51viz	558	29	Determinants	determinant	NNS
cord-280878-1kt51viz	558	30	of	of	IN
cord-280878-1kt51viz	558	31	hepatitis	hepatitis	NN
cord-280878-1kt51viz	558	32	C	C	NNP
cord-280878-1kt51viz	558	33	virus	virus	NN
cord-280878-1kt51viz	558	34	p7	p7	NN
cord-280878-1kt51viz	558	35	ion	ion	NN
cord-280878-1kt51viz	558	36	channel	channel	NN
cord-280878-1kt51viz	558	37	function	function	NN
cord-280878-1kt51viz	558	38	and	and	CC
cord-280878-1kt51viz	558	39	drug	drug	NN
cord-280878-1kt51viz	558	40	sensitivity	sensitivity	NN
cord-280878-1kt51viz	558	41	identified	identify	VBN
cord-280878-1kt51viz	558	42	in	in	IN
cord-280878-1kt51viz	558	43	vitro	vitro	FW
cord-280878-1kt51viz	558	44	Inhibition	inhibition	NN
cord-280878-1kt51viz	558	45	of	of	IN
cord-280878-1kt51viz	558	46	hepatitis	hepatitis	NN
cord-280878-1kt51viz	558	47	C	c	NN
cord-280878-1kt51viz	558	48	virus	virus	NN
cord-280878-1kt51viz	558	49	p7	p7	NN
cord-280878-1kt51viz	558	50	membrane	membrane	NN
cord-280878-1kt51viz	558	51	channels	channel	NNS
cord-280878-1kt51viz	558	52	in	in	IN
cord-280878-1kt51viz	558	53	a	a	DT
cord-280878-1kt51viz	558	54	liposome	liposome	NN
cord-280878-1kt51viz	558	55	-	-	HYPH
cord-280878-1kt51viz	558	56	based	base	VBN
cord-280878-1kt51viz	558	57	assay	assay	NN
cord-280878-1kt51viz	558	58	system	system	NN
cord-280878-1kt51viz	558	59	Structural	structural	JJ
cord-280878-1kt51viz	558	60	basis	basis	NN
cord-280878-1kt51viz	558	61	for	for	IN
cord-280878-1kt51viz	558	62	the	the	DT
cord-280878-1kt51viz	558	63	function	function	NN
cord-280878-1kt51viz	558	64	and	and	CC
cord-280878-1kt51viz	558	65	inhibition	inhibition	NN
cord-280878-1kt51viz	558	66	of	of	IN
cord-280878-1kt51viz	558	67	an	an	DT
cord-280878-1kt51viz	558	68	influenza	influenza	NN
cord-280878-1kt51viz	558	69	virus	virus	NN
cord-280878-1kt51viz	558	70	proton	proton	NN
cord-280878-1kt51viz	558	71	channel	channel	NNP
cord-280878-1kt51viz	559	1	The	the	DT
cord-280878-1kt51viz	559	2	alphaviruses	alphavirus	NNS
cord-280878-1kt51viz	559	3	:	:	:
cord-280878-1kt51viz	559	4	Gene	gene	NN
cord-280878-1kt51viz	559	5	expression	expression	NN
cord-280878-1kt51viz	559	6	,	,	,
cord-280878-1kt51viz	559	7	replication	replication	NN
cord-280878-1kt51viz	559	8	,	,	,
cord-280878-1kt51viz	559	9	and	and	CC
cord-280878-1kt51viz	559	10	evolution	evolution	NN
cord-280878-1kt51viz	559	11	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	559	12	Vpu	Vpu	NNP
cord-280878-1kt51viz	559	13	-	-	:
cord-280878-1kt51viz	559	14	An	an	DT
cord-280878-1kt51viz	559	15	ion	ion	NN
cord-280878-1kt51viz	559	16	channel	channel	NN
cord-280878-1kt51viz	559	17	in	in	IN
cord-280878-1kt51viz	559	18	search	search	NN
cord-280878-1kt51viz	559	19	of	of	IN
cord-280878-1kt51viz	559	20	a	a	DT
cord-280878-1kt51viz	559	21	job	job	NN
cord-280878-1kt51viz	560	1	A	a	DT
cord-280878-1kt51viz	560	2	novel	novel	JJ
cord-280878-1kt51viz	560	3	gene	gene	NN
cord-280878-1kt51viz	560	4	of	of	IN
cord-280878-1kt51viz	560	5	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	560	6	,	,	,
cord-280878-1kt51viz	560	7	vpu	vpu	NN
cord-280878-1kt51viz	560	8	,	,	,
cord-280878-1kt51viz	560	9	and	and	CC
cord-280878-1kt51viz	560	10	its	-PRON-	PRP$
cord-280878-1kt51viz	560	11	16-kilodalton	16-kilodalton	CD
cord-280878-1kt51viz	560	12	product	product	NN
cord-280878-1kt51viz	560	13	Daclatasvir	Daclatasvir	NNP
cord-280878-1kt51viz	560	14	plus	plus	CC
cord-280878-1kt51viz	560	15	sofosbuvir	sofosbuvir	NN
cord-280878-1kt51viz	560	16	for	for	IN
cord-280878-1kt51viz	560	17	previously	previously	RB
cord-280878-1kt51viz	560	18	treated	treat	VBN
cord-280878-1kt51viz	560	19	or	or	CC
cord-280878-1kt51viz	560	20	untreated	untreated	JJ
cord-280878-1kt51viz	560	21	chronic	chronic	NN
cord-280878-1kt51viz	560	22	HCV	HCV	NNP
cord-280878-1kt51viz	560	23	infection	infection	NN
cord-280878-1kt51viz	560	24	Viroporin	Viroporin	NNP
cord-280878-1kt51viz	560	25	activity	activity	NN
cord-280878-1kt51viz	560	26	of	of	IN
cord-280878-1kt51viz	560	27	the	the	DT
cord-280878-1kt51viz	560	28	JC	JC	NNP
cord-280878-1kt51viz	560	29	polyomavirus	polyomavirus	NNP
cord-280878-1kt51viz	560	30	is	be	VBZ
cord-280878-1kt51viz	560	31	regulated	regulate	VBN
cord-280878-1kt51viz	560	32	by	by	IN
cord-280878-1kt51viz	560	33	interactions	interaction	NNS
cord-280878-1kt51viz	560	34	with	with	IN
cord-280878-1kt51viz	560	35	the	the	DT
cord-280878-1kt51viz	560	36	adaptor	adaptor	NN
cord-280878-1kt51viz	560	37	protein	protein	NN
cord-280878-1kt51viz	560	38	complex	complex	NN
cord-280878-1kt51viz	560	39	3	3	CD
cord-280878-1kt51viz	560	40	Disruption	disruption	NN
cord-280878-1kt51viz	560	41	of	of	IN
cord-280878-1kt51viz	560	42	intracellular	intracellular	JJ
cord-280878-1kt51viz	560	43	vesicular	vesicular	JJ
cord-280878-1kt51viz	560	44	trafficking	trafficking	NN
cord-280878-1kt51viz	560	45	by	by	IN
cord-280878-1kt51viz	560	46	agnoprotein	agnoprotein	NNP
cord-280878-1kt51viz	560	47	is	be	VBZ
cord-280878-1kt51viz	560	48	essential	essential	JJ
cord-280878-1kt51viz	560	49	for	for	IN
cord-280878-1kt51viz	560	50	viroporin	viroporin	NN
cord-280878-1kt51viz	560	51	activity	activity	NN
cord-280878-1kt51viz	560	52	and	and	CC
cord-280878-1kt51viz	560	53	JC	JC	NNP
cord-280878-1kt51viz	560	54	virus	virus	NN
cord-280878-1kt51viz	560	55	replication	replication	NN
cord-280878-1kt51viz	561	1	The	the	DT
cord-280878-1kt51viz	561	2	human	human	JJ
cord-280878-1kt51viz	561	3	polyoma	polyoma	NNP
cord-280878-1kt51viz	561	4	JC	JC	NNP
cord-280878-1kt51viz	561	5	virus	virus	NN
cord-280878-1kt51viz	561	6	agnoprotein	agnoprotein	RB
cord-280878-1kt51viz	561	7	acts	act	VBZ
cord-280878-1kt51viz	561	8	as	as	IN
cord-280878-1kt51viz	561	9	a	a	DT
cord-280878-1kt51viz	561	10	viroporin	viroporin	NN
cord-280878-1kt51viz	561	11	Emergence	emergence	NN
cord-280878-1kt51viz	561	12	of	of	IN
cord-280878-1kt51viz	561	13	amantadine	amantadine	NN
cord-280878-1kt51viz	561	14	-	-	HYPH
cord-280878-1kt51viz	561	15	resistant	resistant	JJ
cord-280878-1kt51viz	561	16	influenza	influenza	NN
cord-280878-1kt51viz	561	17	A	a	DT
cord-280878-1kt51viz	561	18	viruses	virus	NNS
cord-280878-1kt51viz	561	19	:	:	:
cord-280878-1kt51viz	562	1	Epidemiological	epidemiological	JJ
cord-280878-1kt51viz	562	2	study	study	NN
cord-280878-1kt51viz	562	3	Influenza	Influenza	NNP
cord-280878-1kt51viz	562	4	virus	virus	NN
cord-280878-1kt51viz	562	5	M2	M2	NNP
cord-280878-1kt51viz	562	6	protein	protein	NN
cord-280878-1kt51viz	562	7	ion	ion	NN
cord-280878-1kt51viz	562	8	channel	channel	NN
cord-280878-1kt51viz	562	9	activity	activity	NN
cord-280878-1kt51viz	562	10	stabilizes	stabilize	VBZ
cord-280878-1kt51viz	562	11	the	the	DT
cord-280878-1kt51viz	562	12	native	native	JJ
cord-280878-1kt51viz	562	13	form	form	NN
cord-280878-1kt51viz	562	14	of	of	IN
cord-280878-1kt51viz	562	15	fowl	fowl	NN
cord-280878-1kt51viz	562	16	plague	plague	NN
cord-280878-1kt51viz	562	17	virus	virus	NN
cord-280878-1kt51viz	562	18	hemagglutinin	hemagglutinin	NN
cord-280878-1kt51viz	562	19	during	during	IN
cord-280878-1kt51viz	562	20	intracellular	intracellular	JJ
cord-280878-1kt51viz	562	21	transport	transport	NN
cord-280878-1kt51viz	562	22	Functional	functional	JJ
cord-280878-1kt51viz	562	23	analyses	analysis	NNS
cord-280878-1kt51viz	562	24	of	of	IN
cord-280878-1kt51viz	562	25	GB	GB	NNP
cord-280878-1kt51viz	562	26	virus	virus	NN
cord-280878-1kt51viz	562	27	B	b	NN
cord-280878-1kt51viz	562	28	p13	p13	NN
cord-280878-1kt51viz	562	29	protein	protein	NN
cord-280878-1kt51viz	562	30	:	:	:
cord-280878-1kt51viz	562	31	Development	development	NN
cord-280878-1kt51viz	562	32	of	of	IN
cord-280878-1kt51viz	562	33	a	a	DT
cord-280878-1kt51viz	562	34	recombinant	recombinant	JJ
cord-280878-1kt51viz	562	35	GB	GB	NNP
cord-280878-1kt51viz	562	36	virus	virus	NN
cord-280878-1kt51viz	562	37	B	b	NN
cord-280878-1kt51viz	562	38	hepatitis	hepatitis	NN
cord-280878-1kt51viz	562	39	virus	virus	NN
cord-280878-1kt51viz	562	40	with	with	IN
cord-280878-1kt51viz	562	41	a	a	DT
cord-280878-1kt51viz	562	42	p7	p7	RB
cord-280878-1kt51viz	562	43	protein	protein	NN
cord-280878-1kt51viz	562	44	Functional	functional	JJ
cord-280878-1kt51viz	562	45	analysis	analysis	NN
cord-280878-1kt51viz	562	46	of	of	IN
cord-280878-1kt51viz	562	47	recombinant	recombinant	JJ
cord-280878-1kt51viz	562	48	respiratory	respiratory	JJ
cord-280878-1kt51viz	562	49	syncytial	syncytial	JJ
cord-280878-1kt51viz	562	50	virus	virus	NN
cord-280878-1kt51viz	562	51	deletion	deletion	NN
cord-280878-1kt51viz	562	52	mutants	mutant	NNS
cord-280878-1kt51viz	562	53	lacking	lack	VBG
cord-280878-1kt51viz	562	54	the	the	DT
cord-280878-1kt51viz	562	55	small	small	JJ
cord-280878-1kt51viz	562	56	hydrophobic	hydrophobic	NN
cord-280878-1kt51viz	562	57	and/or	and/or	CC
cord-280878-1kt51viz	562	58	attachment	attachment	NN
cord-280878-1kt51viz	562	59	glycoprotein	glycoprotein	NN
cord-280878-1kt51viz	562	60	gene	gene	NN
cord-280878-1kt51viz	563	1	The	the	DT
cord-280878-1kt51viz	563	2	subcellular	subcellular	JJ
cord-280878-1kt51viz	563	3	localization	localization	NN
cord-280878-1kt51viz	563	4	of	of	IN
cord-280878-1kt51viz	563	5	the	the	DT
cord-280878-1kt51viz	563	6	hepatitis	hepatitis	NN
cord-280878-1kt51viz	563	7	C	C	NNP
cord-280878-1kt51viz	563	8	virus	virus	NN
cord-280878-1kt51viz	563	9	non	non	JJ
cord-280878-1kt51viz	563	10	-	-	JJ
cord-280878-1kt51viz	563	11	structural	structural	JJ
cord-280878-1kt51viz	563	12	protein	protein	NN
cord-280878-1kt51viz	563	13	NS2	NS2	NNP
cord-280878-1kt51viz	563	14	is	be	VBZ
cord-280878-1kt51viz	563	15	regulated	regulate	VBN
cord-280878-1kt51viz	563	16	by	by	IN
cord-280878-1kt51viz	563	17	an	an	DT
cord-280878-1kt51viz	563	18	ion	ion	NN
cord-280878-1kt51viz	563	19	channel	channel	NN
cord-280878-1kt51viz	563	20	-	-	HYPH
cord-280878-1kt51viz	563	21	independent	independent	JJ
cord-280878-1kt51viz	563	22	function	function	NN
cord-280878-1kt51viz	563	23	of	of	IN
cord-280878-1kt51viz	563	24	the	the	DT
cord-280878-1kt51viz	563	25	p7	p7	NN
cord-280878-1kt51viz	563	26	protein	protein	NN
cord-280878-1kt51viz	564	1	The	the	DT
cord-280878-1kt51viz	564	2	SARS	SARS	NNP
cord-280878-1kt51viz	564	3	coronavirus	coronavirus	NN
cord-280878-1kt51viz	564	4	E	e	NN
cord-280878-1kt51viz	564	5	protein	protein	NN
cord-280878-1kt51viz	564	6	interacts	interact	VBZ
cord-280878-1kt51viz	564	7	with	with	IN
cord-280878-1kt51viz	564	8	PALS1	PALS1	NNS
cord-280878-1kt51viz	564	9	and	and	CC
cord-280878-1kt51viz	564	10	alters	alter	VBZ
cord-280878-1kt51viz	564	11	tight	tight	JJ
cord-280878-1kt51viz	564	12	junction	junction	NN
cord-280878-1kt51viz	564	13	formation	formation	NN
cord-280878-1kt51viz	564	14	and	and	CC
cord-280878-1kt51viz	564	15	epithelial	epithelial	JJ
cord-280878-1kt51viz	564	16	morphogenesis	morphogenesis	NN
cord-280878-1kt51viz	564	17	Functional	functional	JJ
cord-280878-1kt51viz	564	18	role	role	NN
cord-280878-1kt51viz	564	19	of	of	IN
cord-280878-1kt51viz	564	20	human	human	JJ
cord-280878-1kt51viz	564	21	immunodeficiency	immunodeficiency	NN
cord-280878-1kt51viz	564	22	virus	virus	NN
cord-280878-1kt51viz	564	23	type	type	NN
cord-280878-1kt51viz	564	24	1	1	CD
cord-280878-1kt51viz	564	25	vpu	vpu	NN
cord-280878-1kt51viz	564	26	Detection	detection	NN
cord-280878-1kt51viz	564	27	of	of	IN
cord-280878-1kt51viz	564	28	drug	drug	NN
cord-280878-1kt51viz	564	29	-	-	HYPH
cord-280878-1kt51viz	564	30	induced	induce	VBN
cord-280878-1kt51viz	564	31	conformational	conformational	JJ
cord-280878-1kt51viz	564	32	change	change	NN
cord-280878-1kt51viz	564	33	of	of	IN
cord-280878-1kt51viz	564	34	a	a	DT
cord-280878-1kt51viz	564	35	transmembrane	transmembrane	NN
cord-280878-1kt51viz	564	36	protein	protein	NN
cord-280878-1kt51viz	564	37	in	in	IN
cord-280878-1kt51viz	564	38	lipid	lipid	NN
cord-280878-1kt51viz	564	39	bilayers	bilayer	NNS
cord-280878-1kt51viz	564	40	using	use	VBG
cord-280878-1kt51viz	564	41	site	site	NN
cord-280878-1kt51viz	564	42	-	-	HYPH
cord-280878-1kt51viz	564	43	directed	direct	VBN
cord-280878-1kt51viz	564	44	spin	spin	NN
cord-280878-1kt51viz	564	45	labeling	labeling	NN
cord-280878-1kt51viz	564	46	Do	do	VBP
cord-280878-1kt51viz	564	47	viral	viral	JJ
cord-280878-1kt51viz	564	48	proteins	protein	NNS
cord-280878-1kt51viz	564	49	possess	possess	VBP
cord-280878-1kt51viz	564	50	unique	unique	JJ
cord-280878-1kt51viz	564	51	biophysical	biophysical	JJ
cord-280878-1kt51viz	564	52	features	feature	NNS
cord-280878-1kt51viz	564	53	?	?	.
cord-280878-1kt51viz	565	1	Use	use	NN
cord-280878-1kt51viz	565	2	of	of	IN
cord-280878-1kt51viz	565	3	a	a	DT
cord-280878-1kt51viz	565	4	single	single	JJ
cord-280878-1kt51viz	565	5	glycine	glycine	NN
cord-280878-1kt51viz	565	6	residue	residue	NN
cord-280878-1kt51viz	565	7	to	to	TO
cord-280878-1kt51viz	565	8	determine	determine	VB
cord-280878-1kt51viz	565	9	the	the	DT
cord-280878-1kt51viz	565	10	tilt	tilt	NN
cord-280878-1kt51viz	565	11	and	and	CC
cord-280878-1kt51viz	565	12	orientation	orientation	NN
cord-280878-1kt51viz	565	13	of	of	IN
cord-280878-1kt51viz	565	14	a	a	DT
cord-280878-1kt51viz	565	15	transmembrane	transmembrane	JJ
cord-280878-1kt51viz	565	16	helix	helix	NN
cord-280878-1kt51viz	565	17	.	.	.
cord-280878-1kt51viz	566	1	A	a	DT
cord-280878-1kt51viz	566	2	new	new	JJ
cord-280878-1kt51viz	566	3	structural	structural	JJ
cord-280878-1kt51viz	566	4	label	label	NN
cord-280878-1kt51viz	566	5	for	for	IN
cord-280878-1kt51viz	566	6	infrared	infrared	JJ
cord-280878-1kt51viz	566	7	spectroscopy	spectroscopy	NN
cord-280878-1kt51viz	566	8	Conductance	Conductance	NNP
cord-280878-1kt51viz	566	9	and	and	CC
cord-280878-1kt51viz	566	10	amantadine	amantadine	NNP
cord-280878-1kt51viz	566	11	binding	bind	VBG
cord-280878-1kt51viz	566	12	of	of	IN
cord-280878-1kt51viz	566	13	a	a	DT
cord-280878-1kt51viz	566	14	pore	pore	NN
cord-280878-1kt51viz	566	15	formed	form	VBN
cord-280878-1kt51viz	566	16	by	by	IN
cord-280878-1kt51viz	566	17	a	a	DT
cord-280878-1kt51viz	566	18	lysine	lysine	NN
cord-280878-1kt51viz	566	19	-	-	HYPH
cord-280878-1kt51viz	566	20	flanked	flank	VBN
cord-280878-1kt51viz	566	21	transmembrane	transmembrane	NN
cord-280878-1kt51viz	566	22	domain	domain	NN
cord-280878-1kt51viz	566	23	of	of	IN
cord-280878-1kt51viz	566	24	SARS	SARS	NNP
cord-280878-1kt51viz	566	25	coronavirus	coronavirus	NN
cord-280878-1kt51viz	566	26	envelope	envelope	NN
cord-280878-1kt51viz	566	27	protein	protein	NN
cord-280878-1kt51viz	566	28	Model	Model	NNP
cord-280878-1kt51viz	566	29	of	of	IN
cord-280878-1kt51viz	566	30	a	a	DT
cord-280878-1kt51viz	566	31	putative	putative	JJ
cord-280878-1kt51viz	566	32	pore	pore	NN
cord-280878-1kt51viz	566	33	:	:	:
cord-280878-1kt51viz	566	34	The	the	DT
cord-280878-1kt51viz	566	35	pentameric	pentameric	NN
cord-280878-1kt51viz	566	36	α	α	NN
cord-280878-1kt51viz	566	37	-	-	HYPH
cord-280878-1kt51viz	566	38	helical	helical	JJ
cord-280878-1kt51viz	566	39	bundle	bundle	NN
cord-280878-1kt51viz	566	40	of	of	IN
cord-280878-1kt51viz	566	41	SARS	SARS	NNP
cord-280878-1kt51viz	566	42	coronavirus	coronavirus	NN
cord-280878-1kt51viz	566	43	E	e	NN
cord-280878-1kt51viz	566	44	protein	protein	NN
cord-280878-1kt51viz	566	45	in	in	IN
cord-280878-1kt51viz	566	46	lipid	lipid	NN
cord-280878-1kt51viz	566	47	bilayers	bilayer	VBZ
cord-280878-1kt51viz	566	48	Protein	protein	NN
cord-280878-1kt51viz	566	49	-	-	HYPH
cord-280878-1kt51viz	566	50	protein	protein	NN
cord-280878-1kt51viz	566	51	interactions	interaction	NNS
cord-280878-1kt51viz	566	52	of	of	IN
cord-280878-1kt51viz	566	53	viroporins	viroporin	NNS
cord-280878-1kt51viz	566	54	in	in	IN
cord-280878-1kt51viz	566	55	coronaviruses	coronaviruse	NNS
cord-280878-1kt51viz	566	56	and	and	CC
cord-280878-1kt51viz	566	57	paramyxoviruses	paramyxovirus	NNS
cord-280878-1kt51viz	566	58	:	:	:
cord-280878-1kt51viz	566	59	New	new	JJ
cord-280878-1kt51viz	566	60	targets	target	NNS
cord-280878-1kt51viz	566	61	for	for	IN
cord-280878-1kt51viz	566	62	antivirals	antiviral	NNS
cord-280878-1kt51viz	566	63	?	?	.
cord-280878-1kt51viz	567	1	Viruses	virus	NNS
cord-280878-1kt51viz	568	1	The	the	DT
cord-280878-1kt51viz	568	2	transmembrane	transmembrane	NN
cord-280878-1kt51viz	568	3	oligomers	oligomer	NNS
cord-280878-1kt51viz	568	4	of	of	IN
cord-280878-1kt51viz	568	5	coronavirus	coronavirus	NN
cord-280878-1kt51viz	568	6	protein	protein	NN
cord-280878-1kt51viz	568	7	E	E	NNP
cord-280878-1kt51viz	568	8	Human	Human	NNP
cord-280878-1kt51viz	568	9	respiratory	respiratory	JJ
cord-280878-1kt51viz	568	10	syncytial	syncytial	JJ
cord-280878-1kt51viz	568	11	virus	virus	NN
cord-280878-1kt51viz	568	12	viroporin	viroporin	NN
cord-280878-1kt51viz	568	13	SH	SH	NNP
cord-280878-1kt51viz	568	14	:	:	:
cord-280878-1kt51viz	568	15	A	a	DT
cord-280878-1kt51viz	568	16	viral	viral	JJ
cord-280878-1kt51viz	568	17	recognition	recognition	NN
cord-280878-1kt51viz	568	18	pathway	pathway	NN
cord-280878-1kt51viz	568	19	used	use	VBN
cord-280878-1kt51viz	568	20	by	by	IN
cord-280878-1kt51viz	568	21	the	the	DT
cord-280878-1kt51viz	568	22	host	host	NN
cord-280878-1kt51viz	568	23	to	to	TO
cord-280878-1kt51viz	568	24	signal	signal	VB
cord-280878-1kt51viz	568	25	inflammasome	inflammasome	NNP
cord-280878-1kt51viz	568	26	activation	activation	NN
cord-280878-1kt51viz	568	27	Rhinovirusinduced	Rhinovirusinduced	NNP
cord-280878-1kt51viz	568	28	calcium	calcium	NN
cord-280878-1kt51viz	568	29	flux	flux	NN
cord-280878-1kt51viz	568	30	triggers	trigger	VBZ
cord-280878-1kt51viz	568	31	NLRP3	nlrp3	NN
cord-280878-1kt51viz	568	32	and	and	CC
cord-280878-1kt51viz	568	33	NLRC5	nlrc5	JJ
cord-280878-1kt51viz	568	34	activation	activation	NN
cord-280878-1kt51viz	568	35	in	in	IN
cord-280878-1kt51viz	568	36	bronchial	bronchial	JJ
cord-280878-1kt51viz	568	37	cells	cell	NNS
cord-280878-1kt51viz	569	1	The	the	DT
cord-280878-1kt51viz	569	2	9-kDa	9-kda	CD
cord-280878-1kt51viz	569	3	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	569	4	protein	protein	NN
cord-280878-1kt51viz	569	5	encoded	encode	VBN
cord-280878-1kt51viz	569	6	at	at	IN
cord-280878-1kt51viz	569	7	the	the	DT
cord-280878-1kt51viz	569	8	3	3	CD
cord-280878-1kt51viz	569	9	0	0	CD
cord-280878-1kt51viz	569	10	end	end	NN
cord-280878-1kt51viz	569	11	of	of	IN
cord-280878-1kt51viz	569	12	the	the	DT
cord-280878-1kt51viz	569	13	porcine	porcine	JJ
cord-280878-1kt51viz	569	14	transmissible	transmissible	JJ
cord-280878-1kt51viz	569	15	gastroenteritis	gastroenteritis	NN
cord-280878-1kt51viz	569	16	coronavirus	coronavirus	NN
cord-280878-1kt51viz	569	17	genome	genome	NN
cord-280878-1kt51viz	569	18	is	be	VBZ
cord-280878-1kt51viz	569	19	membrane	membrane	NN
cord-280878-1kt51viz	569	20	-	-	HYPH
cord-280878-1kt51viz	569	21	associated	associate	VBN
cord-280878-1kt51viz	569	22	The	the	DT
cord-280878-1kt51viz	569	23	interferon	interferon	NN
cord-280878-1kt51viz	569	24	-	-	HYPH
cord-280878-1kt51viz	569	25	induced	induce	VBN
cord-280878-1kt51viz	569	26	protein	protein	NN
cord-280878-1kt51viz	569	27	BST-2	BST-2	NNP
cord-280878-1kt51viz	569	28	restricts	restrict	VBZ
cord-280878-1kt51viz	569	29	HIV-1	HIV-1	NNP
cord-280878-1kt51viz	569	30	release	release	NN
cord-280878-1kt51viz	569	31	and	and	CC
cord-280878-1kt51viz	569	32	is	be	VBZ
cord-280878-1kt51viz	569	33	downregulated	downregulate	VBN
cord-280878-1kt51viz	569	34	from	from	IN
cord-280878-1kt51viz	569	35	the	the	DT
cord-280878-1kt51viz	569	36	cell	cell	NN
cord-280878-1kt51viz	569	37	surface	surface	NN
cord-280878-1kt51viz	569	38	by	by	IN
cord-280878-1kt51viz	569	39	the	the	DT
cord-280878-1kt51viz	569	40	viral	viral	JJ
cord-280878-1kt51viz	569	41	Vpu	Vpu	NNP
cord-280878-1kt51viz	569	42	protein	protein	NN
cord-280878-1kt51viz	569	43	Coxsackie	Coxsackie	NNP
cord-280878-1kt51viz	569	44	B3	B3	NNP
cord-280878-1kt51viz	569	45	virus	virus	NN
cord-280878-1kt51viz	569	46	protein	protein	NN
cord-280878-1kt51viz	569	47	2B	2B	NNP
cord-280878-1kt51viz	569	48	contains	contain	VBZ
cord-280878-1kt51viz	569	49	a	a	DT
cord-280878-1kt51viz	569	50	cationic	cationic	JJ
cord-280878-1kt51viz	569	51	amphipathic	amphipathic	JJ
cord-280878-1kt51viz	569	52	helix	helix	NN
cord-280878-1kt51viz	569	53	that	that	WDT
cord-280878-1kt51viz	569	54	is	be	VBZ
cord-280878-1kt51viz	569	55	required	require	VBN
cord-280878-1kt51viz	569	56	for	for	IN
cord-280878-1kt51viz	569	57	viral	viral	JJ
cord-280878-1kt51viz	569	58	RNA	RNA	NNP
cord-280878-1kt51viz	569	59	replication	replication	NN
cord-280878-1kt51viz	569	60	Emerging	emerge	VBG
cord-280878-1kt51viz	569	61	antiviral	antiviral	JJ
cord-280878-1kt51viz	569	62	strategies	strategy	NNS
cord-280878-1kt51viz	569	63	to	to	TO
cord-280878-1kt51viz	569	64	interfere	interfere	VB
cord-280878-1kt51viz	569	65	with	with	IN
cord-280878-1kt51viz	569	66	influenza	influenza	NN
cord-280878-1kt51viz	569	67	virus	virus	NN
cord-280878-1kt51viz	569	68	entry	entry	NN
cord-280878-1kt51viz	569	69	Nucleocapsid	nucleocapsid	JJ
cord-280878-1kt51viz	569	70	-	-	HYPH
cord-280878-1kt51viz	569	71	independent	independent	JJ
cord-280878-1kt51viz	569	72	assembly	assembly	NN
cord-280878-1kt51viz	569	73	of	of	IN
cord-280878-1kt51viz	569	74	coronavirus	coronavirus	NN
cord-280878-1kt51viz	569	75	-	-	HYPH
cord-280878-1kt51viz	569	76	like	like	JJ
cord-280878-1kt51viz	569	77	particles	particle	NNS
cord-280878-1kt51viz	569	78	by	by	IN
cord-280878-1kt51viz	569	79	co	co	NN
cord-280878-1kt51viz	569	80	-	-	NN
cord-280878-1kt51viz	569	81	expression	expression	NN
cord-280878-1kt51viz	569	82	of	of	IN
cord-280878-1kt51viz	569	83	viral	viral	JJ
cord-280878-1kt51viz	569	84	envelope	envelope	NN
cord-280878-1kt51viz	569	85	protein	protein	NN
cord-280878-1kt51viz	569	86	genes	gene	NNS
cord-280878-1kt51viz	569	87	Coronavirus	Coronavirus	NNP
cord-280878-1kt51viz	569	88	E	E	NNP
cord-280878-1kt51viz	569	89	protein	protein	NN
cord-280878-1kt51viz	569	90	forms	form	NNS
cord-280878-1kt51viz	569	91	ion	ion	NN
cord-280878-1kt51viz	569	92	channels	channel	NNS
cord-280878-1kt51viz	569	93	with	with	IN
cord-280878-1kt51viz	569	94	functionally	functionally	RB
cord-280878-1kt51viz	569	95	and	and	CC
cord-280878-1kt51viz	569	96	structurally	structurally	RB
cord-280878-1kt51viz	569	97	-	-	HYPH
cord-280878-1kt51viz	569	98	involved	involve	VBN
cord-280878-1kt51viz	569	99	membrane	membrane	NN
cord-280878-1kt51viz	569	100	lipids	lipid	NNS
cord-280878-1kt51viz	570	1	DoGSiteScorer	dogsitescorer	CD
cord-280878-1kt51viz	570	2	:	:	:
cord-280878-1kt51viz	571	1	A	a	DT
cord-280878-1kt51viz	571	2	web	web	NN
cord-280878-1kt51viz	571	3	server	server	NN
cord-280878-1kt51viz	571	4	for	for	IN
cord-280878-1kt51viz	571	5	automatic	automatic	JJ
cord-280878-1kt51viz	571	6	binding	binding	NN
cord-280878-1kt51viz	571	7	site	site	NN
cord-280878-1kt51viz	571	8	prediction	prediction	NN
cord-280878-1kt51viz	571	9	,	,	,
cord-280878-1kt51viz	571	10	analysis	analysis	NN
cord-280878-1kt51viz	571	11	and	and	CC
cord-280878-1kt51viz	571	12	druggability	druggability	NN
cord-280878-1kt51viz	571	13	assessment	assessment	NN
cord-280878-1kt51viz	571	14	Production	Production	NNP
cord-280878-1kt51viz	571	15	of	of	IN
cord-280878-1kt51viz	571	16	infectious	infectious	JJ
cord-280878-1kt51viz	571	17	hepatitis	hepatitis	NN
cord-280878-1kt51viz	571	18	C	C	NNP
cord-280878-1kt51viz	571	19	virus	virus	NN
cord-280878-1kt51viz	571	20	in	in	IN
cord-280878-1kt51viz	571	21	tissue	tissue	NN
cord-280878-1kt51viz	571	22	culture	culture	NN
cord-280878-1kt51viz	571	23	from	from	IN
cord-280878-1kt51viz	571	24	a	a	DT
cord-280878-1kt51viz	571	25	cloned	clone	VBN
cord-280878-1kt51viz	571	26	viral	viral	JJ
cord-280878-1kt51viz	571	27	genome	genome	NN
cord-280878-1kt51viz	571	28	Hydrocarbon	hydrocarbon	NN
cord-280878-1kt51viz	571	29	-	-	HYPH
cord-280878-1kt51viz	571	30	stapled	staple	VBN
cord-280878-1kt51viz	571	31	peptides	peptide	NNS
cord-280878-1kt51viz	571	32	:	:	:
cord-280878-1kt51viz	571	33	Principles	principle	NNS
cord-280878-1kt51viz	571	34	,	,	,
cord-280878-1kt51viz	571	35	practice	practice	NN
cord-280878-1kt51viz	571	36	,	,	,
cord-280878-1kt51viz	571	37	and	and	CC
cord-280878-1kt51viz	571	38	progress	progress	VBP
cord-280878-1kt51viz	571	39	Discovery	Discovery	NNP
cord-280878-1kt51viz	571	40	of	of	IN
cord-280878-1kt51viz	571	41	spiro	spiro	NNP
cord-280878-1kt51viz	571	42	-	-	HYPH
cord-280878-1kt51viz	571	43	piperidine	piperidine	NN
cord-280878-1kt51viz	571	44	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	571	45	and	and	CC
cord-280878-1kt51viz	571	46	their	-PRON-	PRP$
cord-280878-1kt51viz	571	47	modulation	modulation	NN
cord-280878-1kt51viz	571	48	of	of	IN
cord-280878-1kt51viz	571	49	the	the	DT
cord-280878-1kt51viz	571	50	dynamics	dynamic	NNS
cord-280878-1kt51viz	571	51	of	of	IN
cord-280878-1kt51viz	571	52	the	the	DT
cord-280878-1kt51viz	571	53	M2	M2	NNP
cord-280878-1kt51viz	571	54	proton	proton	NN
cord-280878-1kt51viz	571	55	channel	channel	NN
cord-280878-1kt51viz	571	56	from	from	IN
cord-280878-1kt51viz	571	57	influenza	influenza	NN
cord-280878-1kt51viz	571	58	a	a	DT
cord-280878-1kt51viz	571	59	virus	virus	NN
cord-280878-1kt51viz	571	60	Exploring	explore	VBG
cord-280878-1kt51viz	571	61	the	the	DT
cord-280878-1kt51viz	571	62	requirements	requirement	NNS
cord-280878-1kt51viz	571	63	for	for	IN
cord-280878-1kt51viz	571	64	the	the	DT
cord-280878-1kt51viz	571	65	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	571	66	scaffold	scaffold	NN
cord-280878-1kt51viz	571	67	and	and	CC
cord-280878-1kt51viz	571	68	polar	polar	JJ
cord-280878-1kt51viz	571	69	amine	amine	NN
cord-280878-1kt51viz	571	70	in	in	IN
cord-280878-1kt51viz	571	71	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	571	72	of	of	IN
cord-280878-1kt51viz	571	73	M2	M2	NNP
cord-280878-1kt51viz	571	74	from	from	IN
cord-280878-1kt51viz	572	1	influenza	influenza	NN
cord-280878-1kt51viz	572	2	A	a	DT
cord-280878-1kt51viz	572	3	virus	virus	NN
cord-280878-1kt51viz	572	4	Molecular	Molecular	NNP
cord-280878-1kt51viz	572	5	dynamics	dynamic	NNS
cord-280878-1kt51viz	572	6	simulation	simulation	NN
cord-280878-1kt51viz	572	7	directed	direct	VBD
cord-280878-1kt51viz	572	8	rational	rational	JJ
cord-280878-1kt51viz	572	9	design	design	NN
cord-280878-1kt51viz	572	10	of	of	IN
cord-280878-1kt51viz	572	11	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	572	12	targeting	target	VBG
cord-280878-1kt51viz	572	13	drug	drug	NN
cord-280878-1kt51viz	572	14	-	-	HYPH
cord-280878-1kt51viz	572	15	resistant	resistant	JJ
cord-280878-1kt51viz	572	16	mutants	mutant	NNS
cord-280878-1kt51viz	572	17	of	of	IN
cord-280878-1kt51viz	572	18	influenza	influenza	NN
cord-280878-1kt51viz	572	19	A	a	DT
cord-280878-1kt51viz	572	20	virus	virus	NN
cord-280878-1kt51viz	572	21	M2	M2	NNP
cord-280878-1kt51viz	572	22	Discovery	Discovery	NNP
cord-280878-1kt51viz	572	23	of	of	IN
cord-280878-1kt51viz	572	24	novel	novel	JJ
cord-280878-1kt51viz	572	25	dual	dual	JJ
cord-280878-1kt51viz	572	26	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	572	27	of	of	IN
cord-280878-1kt51viz	572	28	the	the	DT
cord-280878-1kt51viz	572	29	wild	wild	JJ
cord-280878-1kt51viz	572	30	-	-	HYPH
cord-280878-1kt51viz	572	31	type	type	NN
cord-280878-1kt51viz	572	32	and	and	CC
cord-280878-1kt51viz	572	33	the	the	DT
cord-280878-1kt51viz	572	34	most	most	RBS
cord-280878-1kt51viz	572	35	prevalent	prevalent	JJ
cord-280878-1kt51viz	572	36	drug	drug	NN
cord-280878-1kt51viz	572	37	-	-	HYPH
cord-280878-1kt51viz	572	38	resistant	resistant	JJ
cord-280878-1kt51viz	572	39	mutant	mutant	NN
cord-280878-1kt51viz	572	40	,	,	,
cord-280878-1kt51viz	572	41	S31N	S31N	NNP
cord-280878-1kt51viz	572	42	,	,	,
cord-280878-1kt51viz	572	43	of	of	IN
cord-280878-1kt51viz	572	44	the	the	DT
cord-280878-1kt51viz	572	45	M2	M2	NNP
cord-280878-1kt51viz	572	46	proton	proton	NN
cord-280878-1kt51viz	572	47	channel	channel	NN
cord-280878-1kt51viz	572	48	from	from	IN
cord-280878-1kt51viz	572	49	influenza	influenza	NN
cord-280878-1kt51viz	572	50	a	a	DT
cord-280878-1kt51viz	572	51	virus	virus	NN
cord-280878-1kt51viz	572	52	Solution	Solution	NNP
cord-280878-1kt51viz	572	53	structure	structure	NN
cord-280878-1kt51viz	572	54	and	and	CC
cord-280878-1kt51viz	572	55	functional	functional	JJ
cord-280878-1kt51viz	572	56	analysis	analysis	NN
cord-280878-1kt51viz	572	57	of	of	IN
cord-280878-1kt51viz	572	58	the	the	DT
cord-280878-1kt51viz	572	59	influenza	influenza	NN
cord-280878-1kt51viz	572	60	B	B	NNP
cord-280878-1kt51viz	572	61	proton	proton	NN
cord-280878-1kt51viz	572	62	channel	channel	NN
cord-280878-1kt51viz	572	63	Structural	structural	JJ
cord-280878-1kt51viz	572	64	and	and	CC
cord-280878-1kt51viz	572	65	dynamic	dynamic	JJ
cord-280878-1kt51viz	572	66	mechanisms	mechanism	NNS
cord-280878-1kt51viz	572	67	for	for	IN
cord-280878-1kt51viz	572	68	the	the	DT
cord-280878-1kt51viz	572	69	function	function	NN
cord-280878-1kt51viz	572	70	and	and	CC
cord-280878-1kt51viz	572	71	inhibition	inhibition	NN
cord-280878-1kt51viz	572	72	of	of	IN
cord-280878-1kt51viz	572	73	the	the	DT
cord-280878-1kt51viz	572	74	M2	m2	JJ
cord-280878-1kt51viz	572	75	proton	proton	NN
cord-280878-1kt51viz	572	76	channel	channel	NN
cord-280878-1kt51viz	572	77	from	from	IN
cord-280878-1kt51viz	572	78	influenza	influenza	NN
cord-280878-1kt51viz	572	79	A	a	DT
cord-280878-1kt51viz	572	80	virus	virus	NN
cord-280878-1kt51viz	572	81	Structure	structure	NN
cord-280878-1kt51viz	572	82	and	and	CC
cord-280878-1kt51viz	572	83	inhibition	inhibition	NN
cord-280878-1kt51viz	572	84	of	of	IN
cord-280878-1kt51viz	572	85	the	the	DT
cord-280878-1kt51viz	572	86	drug	drug	NN
cord-280878-1kt51viz	572	87	-	-	HYPH
cord-280878-1kt51viz	572	88	resistant	resistant	JJ
cord-280878-1kt51viz	572	89	S31N	S31N	NNP
cord-280878-1kt51viz	572	90	mutant	mutant	NN
cord-280878-1kt51viz	572	91	of	of	IN
cord-280878-1kt51viz	572	92	the	the	DT
cord-280878-1kt51viz	572	93	M2	M2	NNP
cord-280878-1kt51viz	572	94	ion	ion	NN
cord-280878-1kt51viz	572	95	channel	channel	NN
cord-280878-1kt51viz	572	96	of	of	IN
cord-280878-1kt51viz	572	97	influenza	influenza	NN
cord-280878-1kt51viz	572	98	A	a	DT
cord-280878-1kt51viz	572	99	virus	virus	NN
cord-280878-1kt51viz	572	100	Characterization	characterization	NN
cord-280878-1kt51viz	572	101	of	of	IN
cord-280878-1kt51viz	572	102	a	a	DT
cord-280878-1kt51viz	572	103	small	small	JJ
cord-280878-1kt51viz	572	104	,	,	,
cord-280878-1kt51viz	572	105	nonstructural	nonstructural	JJ
cord-280878-1kt51viz	572	106	viral	viral	JJ
cord-280878-1kt51viz	572	107	polypeptide	polypeptide	NN
cord-280878-1kt51viz	572	108	present	present	JJ
cord-280878-1kt51viz	572	109	late	late	RB
cord-280878-1kt51viz	572	110	during	during	IN
cord-280878-1kt51viz	572	111	infection	infection	NN
cord-280878-1kt51viz	572	112	of	of	IN
cord-280878-1kt51viz	572	113	BHK	BHK	NNP
cord-280878-1kt51viz	572	114	cells	cell	NNS
cord-280878-1kt51viz	572	115	by	by	IN
cord-280878-1kt51viz	572	116	Semliki	Semliki	NNP
cord-280878-1kt51viz	572	117	Forest	Forest	NNP
cord-280878-1kt51viz	572	118	virus	virus	NN
cord-280878-1kt51viz	572	119	Recombinant	recombinant	JJ
cord-280878-1kt51viz	572	120	respiratory	respiratory	JJ
cord-280878-1kt51viz	572	121	syncytial	syncytial	JJ
cord-280878-1kt51viz	572	122	virus	virus	NN
cord-280878-1kt51viz	572	123	bearing	bear	VBG
cord-280878-1kt51viz	572	124	a	a	DT
cord-280878-1kt51viz	572	125	deletion	deletion	NN
cord-280878-1kt51viz	572	126	of	of	IN
cord-280878-1kt51viz	572	127	either	either	CC
cord-280878-1kt51viz	572	128	the	the	DT
cord-280878-1kt51viz	572	129	NS2	NS2	NNP
cord-280878-1kt51viz	572	130	or	or	CC
cord-280878-1kt51viz	572	131	SH	SH	NNP
cord-280878-1kt51viz	572	132	gene	gene	NN
cord-280878-1kt51viz	572	133	is	be	VBZ
cord-280878-1kt51viz	572	134	attenuated	attenuate	VBN
cord-280878-1kt51viz	572	135	in	in	IN
cord-280878-1kt51viz	572	136	chimpanzees	chimpanzee	NNS
cord-280878-1kt51viz	572	137	Function	function	NN
cord-280878-1kt51viz	572	138	of	of	IN
cord-280878-1kt51viz	572	139	small	small	JJ
cord-280878-1kt51viz	572	140	hydrophobic	hydrophobic	JJ
cord-280878-1kt51viz	572	141	proteins	protein	NNS
cord-280878-1kt51viz	572	142	of	of	IN
cord-280878-1kt51viz	572	143	paramyxovirus	paramyxovirus	JJ
cord-280878-1kt51viz	572	144	Hexamethylene	Hexamethylene	NNP
cord-280878-1kt51viz	572	145	amiloride	amiloride	NN
cord-280878-1kt51viz	572	146	blocks	block	VBZ
cord-280878-1kt51viz	572	147	E	e	NN
cord-280878-1kt51viz	572	148	protein	protein	NN
cord-280878-1kt51viz	572	149	ion	ion	NN
cord-280878-1kt51viz	572	150	channels	channel	NNS
cord-280878-1kt51viz	572	151	and	and	CC
cord-280878-1kt51viz	572	152	inhibits	inhibit	VBZ
cord-280878-1kt51viz	572	153	coronavirus	coronavirus	NN
cord-280878-1kt51viz	572	154	replication	replication	NN
cord-280878-1kt51viz	572	155	Therapeutic	therapeutic	JJ
cord-280878-1kt51viz	572	156	efficacy	efficacy	NN
cord-280878-1kt51viz	572	157	of	of	IN
cord-280878-1kt51viz	572	158	amantadine	amantadine	NNP
cord-280878-1kt51viz	572	159	HCl	HCl	NNP
cord-280878-1kt51viz	572	160	and	and	CC
cord-280878-1kt51viz	572	161	rimantadine	rimantadine	NNP
cord-280878-1kt51viz	572	162	HCl	HCl	NNP
cord-280878-1kt51viz	572	163	in	in	IN
cord-280878-1kt51viz	572	164	naturally	naturally	RB
cord-280878-1kt51viz	572	165	occurring	occur	VBG
cord-280878-1kt51viz	572	166	influenza	influenza	NN
cord-280878-1kt51viz	572	167	A2	a2	CD
cord-280878-1kt51viz	572	168	respiratory	respiratory	JJ
cord-280878-1kt51viz	572	169	illness	illness	NN
cord-280878-1kt51viz	572	170	in	in	IN
cord-280878-1kt51viz	572	171	man	man	NN
cord-280878-1kt51viz	572	172	Intracellular	Intracellular	NNP
cord-280878-1kt51viz	572	173	proton	proton	NN
cord-280878-1kt51viz	572	174	conductance	conductance	NN
cord-280878-1kt51viz	572	175	of	of	IN
cord-280878-1kt51viz	572	176	the	the	DT
cord-280878-1kt51viz	572	177	hepatitis	hepatitis	NN
cord-280878-1kt51viz	572	178	C	C	NNP
cord-280878-1kt51viz	572	179	virus	virus	NN
cord-280878-1kt51viz	572	180	p7	p7	NN
cord-280878-1kt51viz	572	181	protein	protein	NN
cord-280878-1kt51viz	572	182	and	and	CC
cord-280878-1kt51viz	572	183	its	-PRON-	PRP$
cord-280878-1kt51viz	572	184	contribution	contribution	NN
cord-280878-1kt51viz	572	185	to	to	IN
cord-280878-1kt51viz	572	186	infectious	infectious	JJ
cord-280878-1kt51viz	572	187	virus	virus	NN
cord-280878-1kt51viz	572	188	production	production	NN
cord-280878-1kt51viz	572	189	Flipping	flip	VBG
cord-280878-1kt51viz	572	190	in	in	IN
cord-280878-1kt51viz	572	191	the	the	DT
cord-280878-1kt51viz	572	192	pore	pore	NN
cord-280878-1kt51viz	572	193	:	:	:
cord-280878-1kt51viz	573	1	Discovery	discovery	NN
cord-280878-1kt51viz	573	2	of	of	IN
cord-280878-1kt51viz	573	3	dual	dual	JJ
cord-280878-1kt51viz	573	4	inhibitors	inhibitor	NNS
cord-280878-1kt51viz	573	5	that	that	WDT
cord-280878-1kt51viz	573	6	bind	bind	VBP
cord-280878-1kt51viz	573	7	in	in	RP
cord-280878-1kt51viz	573	8	different	different	JJ
cord-280878-1kt51viz	573	9	orientations	orientation	NNS
cord-280878-1kt51viz	573	10	to	to	IN
cord-280878-1kt51viz	573	11	the	the	DT
cord-280878-1kt51viz	573	12	wild	wild	JJ
cord-280878-1kt51viz	573	13	-	-	HYPH
cord-280878-1kt51viz	573	14	type	type	NN
cord-280878-1kt51viz	573	15	versus	versus	IN
cord-280878-1kt51viz	573	16	the	the	DT
cord-280878-1kt51viz	573	17	amantadine	amantadine	NN
cord-280878-1kt51viz	573	18	-	-	HYPH
cord-280878-1kt51viz	573	19	resistant	resistant	JJ
cord-280878-1kt51viz	573	20	s31n	s31n	CD
cord-280878-1kt51viz	573	21	mutant	mutant	NN
cord-280878-1kt51viz	573	22	of	of	IN
cord-280878-1kt51viz	573	23	the	the	DT
cord-280878-1kt51viz	573	24	influenza	influenza	NN
cord-280878-1kt51viz	573	25	a	a	DT
cord-280878-1kt51viz	573	26	virus	virus	NN
cord-280878-1kt51viz	573	27	m2	m2	NNP
cord-280878-1kt51viz	573	28	proton	proton	NN
cord-280878-1kt51viz	573	29	channel	channel	NN
cord-280878-1kt51viz	573	30	Compensatory	compensatory	JJ
cord-280878-1kt51viz	573	31	mutations	mutation	NNS
cord-280878-1kt51viz	573	32	in	in	IN
cord-280878-1kt51viz	573	33	E1	e1	NN
cord-280878-1kt51viz	573	34	,	,	,
cord-280878-1kt51viz	573	35	p7	p7	RB
cord-280878-1kt51viz	573	36	,	,	,
cord-280878-1kt51viz	573	37	NS2	NS2	NNP
cord-280878-1kt51viz	573	38	,	,	,
cord-280878-1kt51viz	573	39	and	and	CC
cord-280878-1kt51viz	573	40	NS3	ns3	RB
cord-280878-1kt51viz	573	41	enhance	enhance	VB
cord-280878-1kt51viz	573	42	yields	yield	NNS
cord-280878-1kt51viz	573	43	of	of	IN
cord-280878-1kt51viz	573	44	cell	cell	NN
cord-280878-1kt51viz	573	45	culture	culture	NN
cord-280878-1kt51viz	573	46	-	-	HYPH
cord-280878-1kt51viz	573	47	infectious	infectious	JJ
cord-280878-1kt51viz	573	48	intergenotypic	intergenotypic	NN
cord-280878-1kt51viz	574	1	chirneric	chirneric	NNP
cord-280878-1kt51viz	574	2	hepatitis	hepatitis	NNP
cord-280878-1kt51viz	574	3	C	C	NNP
cord-280878-1kt51viz	574	4	virus	virus	NN
cord-280878-1kt51viz	574	5	Mouse	Mouse	NNP
cord-280878-1kt51viz	574	6	hepatitis	hepatitis	NN
cord-280878-1kt51viz	574	7	virus	virus	NN
cord-280878-1kt51viz	574	8	gene	gene	NN
cord-280878-1kt51viz	574	9	5b	5b	CD
cord-280878-1kt51viz	574	10	protein	protein	NN
cord-280878-1kt51viz	574	11	is	be	VBZ
cord-280878-1kt51viz	574	12	a	a	DT
cord-280878-1kt51viz	574	13	new	new	JJ
cord-280878-1kt51viz	574	14	virion	virion	NN
cord-280878-1kt51viz	574	15	envelope	envelope	NN
cord-280878-1kt51viz	574	16	protein	protein	NN
cord-280878-1kt51viz	574	17	Inhibition	inhibition	NN
cord-280878-1kt51viz	574	18	of	of	IN
cord-280878-1kt51viz	574	19	respiratory	respiratory	JJ
cord-280878-1kt51viz	574	20	syncytial	syncytial	JJ
cord-280878-1kt51viz	574	21	virus	virus	NN
cord-280878-1kt51viz	574	22	infection	infection	NN
cord-280878-1kt51viz	574	23	with	with	IN
cord-280878-1kt51viz	574	24	intranasal	intranasal	NN
cord-280878-1kt51viz	574	25	siRNA	siRNA	NNP
cord-280878-1kt51viz	574	26	nanoparticles	nanoparticle	NNS
cord-280878-1kt51viz	574	27	targeting	target	VBG
cord-280878-1kt51viz	574	28	the	the	DT
cord-280878-1kt51viz	574	29	viral	viral	JJ
cord-280878-1kt51viz	574	30	NS1	ns1	NN
cord-280878-1kt51viz	574	31	gene	gene	NN
cord-280878-1kt51viz	574	32	Structural	structural	JJ
cord-280878-1kt51viz	574	33	characterization	characterization	NN
cord-280878-1kt51viz	574	34	of	of	IN
cord-280878-1kt51viz	574	35	the	the	DT
cord-280878-1kt51viz	574	36	human	human	JJ
cord-280878-1kt51viz	574	37	respiratory	respiratory	JJ
cord-280878-1kt51viz	574	38	syncytial	syncytial	JJ
cord-280878-1kt51viz	574	39	virus	virus	NN
cord-280878-1kt51viz	574	40	fusion	fusion	NN
cord-280878-1kt51viz	574	41	protein	protein	NN
cord-280878-1kt51viz	574	42	core	core	NN
cord-280878-1kt51viz	574	43	2	2	CD
cord-280878-1kt51viz	574	44	Modeling	modeling	NN
cord-280878-1kt51viz	575	1	the	the	DT
cord-280878-1kt51viz	575	2	membrane	membrane	NN
cord-280878-1kt51viz	575	3	environment	environment	NN
cord-280878-1kt51viz	575	4	has	have	VBZ
cord-280878-1kt51viz	575	5	implications	implication	NNS
cord-280878-1kt51viz	575	6	for	for	IN
cord-280878-1kt51viz	575	7	membrane	membrane	NN
cord-280878-1kt51viz	575	8	protein	protein	NN
cord-280878-1kt51viz	575	9	structure	structure	NN
cord-280878-1kt51viz	575	10	and	and	CC
cord-280878-1kt51viz	575	11	function	function	NN
cord-280878-1kt51viz	575	12	:	:	:
cord-280878-1kt51viz	575	13	Influenza	Influenza	NNP
cord-280878-1kt51viz	575	14	A	a	DT
cord-280878-1kt51viz	575	15	M2	M2	NNP
cord-280878-1kt51viz	575	16	protein	protein	NN
cord-280878-1kt51viz	576	1	This	this	DT
cord-280878-1kt51viz	576	2	work	work	NN
cord-280878-1kt51viz	576	3	has	have	VBZ
cord-280878-1kt51viz	576	4	been	be	VBN
cord-280878-1kt51viz	576	5	funded	fund	VBN
cord-280878-1kt51viz	576	6	by	by	IN
cord-280878-1kt51viz	576	7	Singapore	Singapore	NNP
cord-280878-1kt51viz	576	8	MOE	MOE	NNP
cord-280878-1kt51viz	576	9	Tier	Tier	NNP
cord-280878-1kt51viz	576	10	1	1	CD
cord-280878-1kt51viz	576	11	grant	grant	NN
cord-280878-1kt51viz	576	12	RG	RG	NNP
cord-280878-1kt51viz	576	13	51/13	51/13	CD
cord-280878-1kt51viz	576	14	(	(	-LRB-
cord-280878-1kt51viz	576	15	J.T.	J.T.	NNP
cord-280878-1kt51viz	576	16	)	)	-RRB-
cord-280878-1kt51viz	576	17	.	.	.