id	sid	tid	token	lemma	pos
cord-332422-s15o0hie	1	1	key	key	JJ
cord-332422-s15o0hie	2	1	:	:	:
cord-332422-s15o0hie	2	2	cord-332422-s15o0hie	cord-332422-s15o0hie	CD
cord-332422-s15o0hie	2	3	authors	author	NNS
cord-332422-s15o0hie	2	4	:	:	:
cord-332422-s15o0hie	2	5	Belouzard	Belouzard	NNP
cord-332422-s15o0hie	2	6	,	,	,
cord-332422-s15o0hie	2	7	Sandrine	Sandrine	NNP
cord-332422-s15o0hie	2	8	;	;	:
cord-332422-s15o0hie	2	9	Cocquerel	Cocquerel	NNP
cord-332422-s15o0hie	2	10	,	,	,
cord-332422-s15o0hie	2	11	Laurence	Laurence	NNP
cord-332422-s15o0hie	2	12	;	;	:
cord-332422-s15o0hie	2	13	Dubuisson	Dubuisson	NNP
cord-332422-s15o0hie	2	14	,	,	,
cord-332422-s15o0hie	3	1	Jean	Jean	NNP
cord-332422-s15o0hie	3	2	title	title	NN
cord-332422-s15o0hie	3	3	:	:	:
cord-332422-s15o0hie	3	4	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	3	5	C	C	NNP
cord-332422-s15o0hie	3	6	virus	virus	NN
cord-332422-s15o0hie	3	7	entry	entry	NN
cord-332422-s15o0hie	3	8	into	into	IN
cord-332422-s15o0hie	3	9	the	the	DT
cord-332422-s15o0hie	3	10	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	3	11	date	date	NN
cord-332422-s15o0hie	3	12	:	:	:
cord-332422-s15o0hie	3	13	2011	2011	CD
cord-332422-s15o0hie	3	14	-	-	SYM
cord-332422-s15o0hie	3	15	11	11	CD
cord-332422-s15o0hie	3	16	-	-	HYPH
cord-332422-s15o0hie	3	17	07	07	CD
cord-332422-s15o0hie	3	18	journal	journal	NN
cord-332422-s15o0hie	3	19	:	:	:
cord-332422-s15o0hie	4	1	Cent	Cent	NNP
cord-332422-s15o0hie	4	2	Eur	Eur	NNP
cord-332422-s15o0hie	4	3	J	J	NNP
cord-332422-s15o0hie	4	4	Biol	Biol	NNP
cord-332422-s15o0hie	4	5	DOI	DOI	NNP
cord-332422-s15o0hie	4	6	:	:	:
cord-332422-s15o0hie	4	7	10.2478	10.2478	CD
cord-332422-s15o0hie	4	8	/	/	SYM
cord-332422-s15o0hie	4	9	s11535	s11535	CD
cord-332422-s15o0hie	4	10	-	-	HYPH
cord-332422-s15o0hie	4	11	011	011	CD
cord-332422-s15o0hie	4	12	-	-	HYPH
cord-332422-s15o0hie	4	13	0076-y	0076-y	NN
cord-332422-s15o0hie	4	14	sha	sha	NNP
cord-332422-s15o0hie	4	15	:	:	:
cord-332422-s15o0hie	4	16	85641d021daf18df153d6aaa39e13a235b88236c	85641d021daf18df153d6aaa39e13a235b88236c	NNP
cord-332422-s15o0hie	4	17	doc_id	doc_id	NNP
cord-332422-s15o0hie	4	18	:	:	:
cord-332422-s15o0hie	4	19	332422	332422	CD
cord-332422-s15o0hie	4	20	cord_uid	cord_uid	NNS
cord-332422-s15o0hie	4	21	:	:	:
cord-332422-s15o0hie	4	22	s15o0hie	s15o0hie	LS
cord-332422-s15o0hie	4	23	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	4	24	C	C	NNP
cord-332422-s15o0hie	4	25	virus	virus	NN
cord-332422-s15o0hie	4	26	(	(	-LRB-
cord-332422-s15o0hie	4	27	HCV	HCV	NNP
cord-332422-s15o0hie	4	28	)	)	-RRB-
cord-332422-s15o0hie	4	29	is	be	VBZ
cord-332422-s15o0hie	4	30	a	a	DT
cord-332422-s15o0hie	4	31	small	small	JJ
cord-332422-s15o0hie	4	32	enveloped	envelop	VBN
cord-332422-s15o0hie	4	33	virus	virus	NN
cord-332422-s15o0hie	4	34	with	with	IN
cord-332422-s15o0hie	4	35	a	a	DT
cord-332422-s15o0hie	4	36	positive	positive	JJ
cord-332422-s15o0hie	4	37	stranded	strand	VBN
cord-332422-s15o0hie	4	38	RNA	rna	NN
cord-332422-s15o0hie	4	39	genome	genome	NN
cord-332422-s15o0hie	4	40	belonging	belong	VBG
cord-332422-s15o0hie	4	41	to	to	IN
cord-332422-s15o0hie	4	42	the	the	DT
cord-332422-s15o0hie	4	43	Flaviviridae	Flaviviridae	NNP
cord-332422-s15o0hie	4	44	family	family	NN
cord-332422-s15o0hie	4	45	.	.	.
cord-332422-s15o0hie	5	1	The	the	DT
cord-332422-s15o0hie	5	2	virion	virion	NN
cord-332422-s15o0hie	5	3	has	have	VBZ
cord-332422-s15o0hie	5	4	the	the	DT
cord-332422-s15o0hie	5	5	unique	unique	JJ
cord-332422-s15o0hie	5	6	ability	ability	NN
cord-332422-s15o0hie	5	7	of	of	IN
cord-332422-s15o0hie	5	8	forming	form	VBG
cord-332422-s15o0hie	5	9	a	a	DT
cord-332422-s15o0hie	5	10	complex	complex	NN
cord-332422-s15o0hie	5	11	with	with	IN
cord-332422-s15o0hie	5	12	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	5	13	,	,	,
cord-332422-s15o0hie	5	14	which	which	WDT
cord-332422-s15o0hie	5	15	is	be	VBZ
cord-332422-s15o0hie	5	16	known	know	VBN
cord-332422-s15o0hie	5	17	as	as	IN
cord-332422-s15o0hie	5	18	the	the	DT
cord-332422-s15o0hie	5	19	lipoviroparticle	lipoviroparticle	NNP
cord-332422-s15o0hie	5	20	.	.	.
cord-332422-s15o0hie	6	1	Lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	6	2	components	component	NNS
cord-332422-s15o0hie	6	3	as	as	RB
cord-332422-s15o0hie	6	4	well	well	RB
cord-332422-s15o0hie	6	5	as	as	IN
cord-332422-s15o0hie	6	6	the	the	DT
cord-332422-s15o0hie	6	7	envelope	envelope	NN
cord-332422-s15o0hie	6	8	proteins	protein	NNS
cord-332422-s15o0hie	6	9	,	,	,
cord-332422-s15o0hie	6	10	E1	E1	NNP
cord-332422-s15o0hie	6	11	and	and	CC
cord-332422-s15o0hie	6	12	E2	E2	NNP
cord-332422-s15o0hie	6	13	,	,	,
cord-332422-s15o0hie	6	14	play	play	VB
cord-332422-s15o0hie	6	15	a	a	DT
cord-332422-s15o0hie	6	16	key	key	JJ
cord-332422-s15o0hie	6	17	role	role	NN
cord-332422-s15o0hie	6	18	in	in	IN
cord-332422-s15o0hie	6	19	virus	virus	NN
cord-332422-s15o0hie	6	20	entry	entry	NN
cord-332422-s15o0hie	6	21	into	into	IN
cord-332422-s15o0hie	6	22	the	the	DT
cord-332422-s15o0hie	6	23	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	6	24	.	.	.
cord-332422-s15o0hie	7	1	HCV	HCV	NNP
cord-332422-s15o0hie	7	2	entry	entry	NN
cord-332422-s15o0hie	7	3	is	be	VBZ
cord-332422-s15o0hie	7	4	a	a	DT
cord-332422-s15o0hie	7	5	complex	complex	JJ
cord-332422-s15o0hie	7	6	multistep	multistep	NN
cord-332422-s15o0hie	7	7	process	process	NN
cord-332422-s15o0hie	7	8	involving	involve	VBG
cord-332422-s15o0hie	7	9	sequential	sequential	JJ
cord-332422-s15o0hie	7	10	interactions	interaction	NNS
cord-332422-s15o0hie	7	11	with	with	IN
cord-332422-s15o0hie	7	12	several	several	JJ
cord-332422-s15o0hie	7	13	cell	cell	NN
cord-332422-s15o0hie	7	14	surface	surface	NN
cord-332422-s15o0hie	7	15	proteins	protein	NNS
cord-332422-s15o0hie	7	16	.	.	.
cord-332422-s15o0hie	8	1	The	the	DT
cord-332422-s15o0hie	8	2	virus	virus	NN
cord-332422-s15o0hie	8	3	relies	rely	VBZ
cord-332422-s15o0hie	8	4	on	on	IN
cord-332422-s15o0hie	8	5	glycosaminoglycans	glycosaminoglycan	NNS
cord-332422-s15o0hie	8	6	and	and	CC
cord-332422-s15o0hie	8	7	possibly	possibly	RB
cord-332422-s15o0hie	8	8	the	the	DT
cord-332422-s15o0hie	8	9	low	low	JJ
cord-332422-s15o0hie	8	10	-	-	HYPH
cord-332422-s15o0hie	8	11	density	density	NN
cord-332422-s15o0hie	8	12	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	8	13	receptors	receptor	NNS
cord-332422-s15o0hie	8	14	to	to	TO
cord-332422-s15o0hie	8	15	attach	attach	VB
cord-332422-s15o0hie	8	16	to	to	IN
cord-332422-s15o0hie	8	17	cells	cell	NNS
cord-332422-s15o0hie	8	18	.	.	.
cord-332422-s15o0hie	9	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	9	2	,	,	,
cord-332422-s15o0hie	9	3	four	four	CD
cord-332422-s15o0hie	9	4	specific	specific	JJ
cord-332422-s15o0hie	9	5	entry	entry	NN
cord-332422-s15o0hie	9	6	factors	factor	NNS
cord-332422-s15o0hie	9	7	are	be	VBP
cord-332422-s15o0hie	9	8	involved	involve	VBN
cord-332422-s15o0hie	9	9	in	in	IN
cord-332422-s15o0hie	9	10	the	the	DT
cord-332422-s15o0hie	9	11	following	following	JJ
cord-332422-s15o0hie	9	12	steps	step	NNS
cord-332422-s15o0hie	9	13	which	which	WDT
cord-332422-s15o0hie	9	14	lead	lead	VBP
cord-332422-s15o0hie	9	15	to	to	IN
cord-332422-s15o0hie	9	16	virus	virus	NN
cord-332422-s15o0hie	9	17	internalization	internalization	NN
cord-332422-s15o0hie	9	18	and	and	CC
cord-332422-s15o0hie	9	19	fusion	fusion	NN
cord-332422-s15o0hie	9	20	in	in	IN
cord-332422-s15o0hie	9	21	early	early	JJ
cord-332422-s15o0hie	9	22	endosomes	endosome	NNS
cord-332422-s15o0hie	9	23	.	.	.
cord-332422-s15o0hie	10	1	These	these	DT
cord-332422-s15o0hie	10	2	molecules	molecule	NNS
cord-332422-s15o0hie	10	3	are	be	VBP
cord-332422-s15o0hie	10	4	the	the	DT
cord-332422-s15o0hie	10	5	scavenger	scavenger	NN
cord-332422-s15o0hie	10	6	receptor	receptor	NN
cord-332422-s15o0hie	10	7	SRB1	SRB1	NNP
cord-332422-s15o0hie	10	8	,	,	,
cord-332422-s15o0hie	10	9	tetraspanin	tetraspanin	NNP
cord-332422-s15o0hie	10	10	CD81	CD81	NNP
cord-332422-s15o0hie	10	11	and	and	CC
cord-332422-s15o0hie	10	12	two	two	CD
cord-332422-s15o0hie	10	13	tight	tight	JJ
cord-332422-s15o0hie	10	14	junction	junction	NN
cord-332422-s15o0hie	10	15	proteins	protein	NNS
cord-332422-s15o0hie	10	16	,	,	,
cord-332422-s15o0hie	10	17	Claudin-1	Claudin-1	NNP
cord-332422-s15o0hie	10	18	and	and	CC
cord-332422-s15o0hie	10	19	Occludin	Occludin	NNP
cord-332422-s15o0hie	10	20	.	.	.
cord-332422-s15o0hie	11	1	Although	although	IN
cord-332422-s15o0hie	11	2	they	-PRON-	PRP
cord-332422-s15o0hie	11	3	are	be	VBP
cord-332422-s15o0hie	11	4	essential	essential	JJ
cord-332422-s15o0hie	11	5	to	to	IN
cord-332422-s15o0hie	11	6	HCV	HCV	NNP
cord-332422-s15o0hie	11	7	entry	entry	NN
cord-332422-s15o0hie	11	8	,	,	,
cord-332422-s15o0hie	11	9	the	the	DT
cord-332422-s15o0hie	11	10	precise	precise	JJ
cord-332422-s15o0hie	11	11	role	role	NN
cord-332422-s15o0hie	11	12	of	of	IN
cord-332422-s15o0hie	11	13	these	these	DT
cord-332422-s15o0hie	11	14	molecules	molecule	NNS
cord-332422-s15o0hie	11	15	is	be	VBZ
cord-332422-s15o0hie	11	16	not	not	RB
cord-332422-s15o0hie	11	17	completely	completely	RB
cord-332422-s15o0hie	11	18	understood	understand	VBN
cord-332422-s15o0hie	11	19	.	.	.
cord-332422-s15o0hie	12	1	Finally	finally	RB
cord-332422-s15o0hie	12	2	,	,	,
cord-332422-s15o0hie	12	3	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	12	4	are	be	VBP
cord-332422-s15o0hie	12	5	highly	highly	RB
cord-332422-s15o0hie	12	6	polarized	polarized	JJ
cord-332422-s15o0hie	12	7	cells	cell	NNS
cord-332422-s15o0hie	12	8	and	and	CC
cord-332422-s15o0hie	12	9	which	which	WDT
cord-332422-s15o0hie	12	10	likely	likely	RB
cord-332422-s15o0hie	12	11	affects	affect	VBZ
cord-332422-s15o0hie	12	12	the	the	DT
cord-332422-s15o0hie	12	13	entry	entry	NN
cord-332422-s15o0hie	12	14	process	process	NN
cord-332422-s15o0hie	12	15	.	.	.
cord-332422-s15o0hie	13	1	Our	-PRON-	PRP$
cord-332422-s15o0hie	13	2	current	current	JJ
cord-332422-s15o0hie	13	3	knowledge	knowledge	NN
cord-332422-s15o0hie	13	4	on	on	IN
cord-332422-s15o0hie	13	5	HCV	HCV	NNP
cord-332422-s15o0hie	13	6	entry	entry	NN
cord-332422-s15o0hie	13	7	is	be	VBZ
cord-332422-s15o0hie	13	8	summarized	summarize	VBN
cord-332422-s15o0hie	13	9	in	in	IN
cord-332422-s15o0hie	13	10	this	this	DT
cord-332422-s15o0hie	13	11	review	review	NN
cord-332422-s15o0hie	13	12	.	.	.
cord-332422-s15o0hie	14	1	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	14	2	C	C	NNP
cord-332422-s15o0hie	14	3	is	be	VBZ
cord-332422-s15o0hie	14	4	a	a	DT
cord-332422-s15o0hie	14	5	global	global	JJ
cord-332422-s15o0hie	14	6	health	health	NN
cord-332422-s15o0hie	14	7	problem	problem	NN
cord-332422-s15o0hie	14	8	.	.	.
cord-332422-s15o0hie	15	1	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	15	2	C	C	NNP
cord-332422-s15o0hie	15	3	virus	virus	NN
cord-332422-s15o0hie	15	4	(	(	-LRB-
cord-332422-s15o0hie	15	5	HCV	HCV	NNP
cord-332422-s15o0hie	15	6	)	)	-RRB-
cord-332422-s15o0hie	15	7	infects	infect	VBZ
cord-332422-s15o0hie	15	8	approximately	approximately	RB
cord-332422-s15o0hie	15	9	130	130	CD
cord-332422-s15o0hie	15	10	millions	million	NNS
cord-332422-s15o0hie	15	11	individuals	individual	NNS
cord-332422-s15o0hie	15	12	worldwide	worldwide	RB
cord-332422-s15o0hie	15	13	with	with	IN
cord-332422-s15o0hie	15	14	the	the	DT
cord-332422-s15o0hie	15	15	majority	majority	NN
cord-332422-s15o0hie	15	16	remaining	remain	VBG
cord-332422-s15o0hie	15	17	undiagnosed	undiagnosed	JJ
cord-332422-s15o0hie	15	18	and	and	CC
cord-332422-s15o0hie	15	19	untreated	untreated	JJ
cord-332422-s15o0hie	15	20	.	.	.
cord-332422-s15o0hie	16	1	In	in	IN
cord-332422-s15o0hie	16	2	most	most	RBS
cord-332422-s15o0hie	16	3	infected	infected	JJ
cord-332422-s15o0hie	16	4	individuals	individual	NNS
cord-332422-s15o0hie	16	5	,	,	,
cord-332422-s15o0hie	16	6	the	the	DT
cord-332422-s15o0hie	16	7	virus	virus	NN
cord-332422-s15o0hie	16	8	evades	evade	VBZ
cord-332422-s15o0hie	16	9	the	the	DT
cord-332422-s15o0hie	16	10	immune	immune	JJ
cord-332422-s15o0hie	16	11	system	system	NN
cord-332422-s15o0hie	16	12	and	and	CC
cord-332422-s15o0hie	16	13	establishes	establish	VBZ
cord-332422-s15o0hie	16	14	a	a	DT
cord-332422-s15o0hie	16	15	chronic	chronic	JJ
cord-332422-s15o0hie	16	16	infection	infection	NN
cord-332422-s15o0hie	16	17	.	.	.
cord-332422-s15o0hie	17	1	As	as	IN
cord-332422-s15o0hie	17	2	a	a	DT
cord-332422-s15o0hie	17	3	consequence	consequence	NN
cord-332422-s15o0hie	17	4	,	,	,
cord-332422-s15o0hie	17	5	hepatitis	hepatitis	NN
cord-332422-s15o0hie	17	6	C	C	NNP
cord-332422-s15o0hie	17	7	is	be	VBZ
cord-332422-s15o0hie	17	8	the	the	DT
cord-332422-s15o0hie	17	9	leading	leading	JJ
cord-332422-s15o0hie	17	10	cause	cause	NN
cord-332422-s15o0hie	17	11	of	of	IN
cord-332422-s15o0hie	17	12	cirrhosis	cirrhosis	NN
cord-332422-s15o0hie	17	13	,	,	,
cord-332422-s15o0hie	17	14	end	end	NN
cord-332422-s15o0hie	17	15	-	-	HYPH
cord-332422-s15o0hie	17	16	stage	stage	NN
cord-332422-s15o0hie	17	17	liver	liver	NN
cord-332422-s15o0hie	17	18	disease	disease	NN
cord-332422-s15o0hie	17	19	,	,	,
cord-332422-s15o0hie	17	20	hepatocellular	hepatocellular	JJ
cord-332422-s15o0hie	17	21	carcinoma	carcinoma	NN
cord-332422-s15o0hie	17	22	and	and	CC
cord-332422-s15o0hie	17	23	liver	liver	NN
cord-332422-s15o0hie	17	24	transplantation	transplantation	NN
cord-332422-s15o0hie	17	25	.	.	.
cord-332422-s15o0hie	18	1	To	to	IN
cord-332422-s15o0hie	18	2	this	this	DT
cord-332422-s15o0hie	18	3	day	day	NN
cord-332422-s15o0hie	18	4	,	,	,
cord-332422-s15o0hie	18	5	there	there	EX
cord-332422-s15o0hie	18	6	is	be	VBZ
cord-332422-s15o0hie	18	7	no	no	DT
cord-332422-s15o0hie	18	8	vaccine	vaccine	NN
cord-332422-s15o0hie	18	9	and	and	CC
cord-332422-s15o0hie	18	10	the	the	DT
cord-332422-s15o0hie	18	11	available	available	JJ
cord-332422-s15o0hie	18	12	treatment	treatment	NN
cord-332422-s15o0hie	18	13	,	,	,
cord-332422-s15o0hie	18	14	a	a	DT
cord-332422-s15o0hie	18	15	combination	combination	NN
cord-332422-s15o0hie	18	16	of	of	IN
cord-332422-s15o0hie	18	17	pegylated	pegylated	JJ
cord-332422-s15o0hie	18	18	α	α	NN
cord-332422-s15o0hie	18	19	-	-	HYPH
cord-332422-s15o0hie	18	20	interferon	interferon	NN
cord-332422-s15o0hie	18	21	and	and	CC
cord-332422-s15o0hie	18	22	ribavirin	ribavirin	NN
cord-332422-s15o0hie	18	23	has	have	VBZ
cord-332422-s15o0hie	18	24	a	a	DT
cord-332422-s15o0hie	18	25	limited	limited	JJ
cord-332422-s15o0hie	18	26	efficacy	efficacy	NN
cord-332422-s15o0hie	18	27	and	and	CC
cord-332422-s15o0hie	18	28	significant	significant	JJ
cord-332422-s15o0hie	18	29	side	side	NN
cord-332422-s15o0hie	18	30	effects	effect	NNS
cord-332422-s15o0hie	18	31	.	.	.
cord-332422-s15o0hie	19	1	However	however	RB
cord-332422-s15o0hie	19	2	,	,	,
cord-332422-s15o0hie	19	3	specific	specific	JJ
cord-332422-s15o0hie	19	4	direct	direct	JJ
cord-332422-s15o0hie	19	5	-	-	HYPH
cord-332422-s15o0hie	19	6	acting	act	VBG
cord-332422-s15o0hie	19	7	antivirals	antiviral	NNS
cord-332422-s15o0hie	19	8	such	such	JJ
cord-332422-s15o0hie	19	9	as	as	IN
cord-332422-s15o0hie	19	10	protease	protease	NN
cord-332422-s15o0hie	19	11	and	and	CC
cord-332422-s15o0hie	19	12	polymerase	polymerase	NN
cord-332422-s15o0hie	19	13	inhibitors	inhibitor	NNS
cord-332422-s15o0hie	19	14	are	be	VBP
cord-332422-s15o0hie	19	15	under	under	IN
cord-332422-s15o0hie	19	16	development	development	NN
cord-332422-s15o0hie	19	17	and	and	CC
cord-332422-s15o0hie	19	18	two	two	CD
cord-332422-s15o0hie	19	19	NS3/4A	ns3/4a	JJ
cord-332422-s15o0hie	19	20	protease	protease	NN
cord-332422-s15o0hie	19	21	inhibitors	inhibitor	NNS
cord-332422-s15o0hie	19	22	have	have	VBP
cord-332422-s15o0hie	19	23	already	already	RB
cord-332422-s15o0hie	19	24	been	be	VBN
cord-332422-s15o0hie	19	25	approved	approve	VBN
cord-332422-s15o0hie	19	26	for	for	IN
cord-332422-s15o0hie	19	27	use	use	NN
cord-332422-s15o0hie	19	28	in	in	IN
cord-332422-s15o0hie	19	29	the	the	DT
cord-332422-s15o0hie	19	30	USA	USA	NNP
cord-332422-s15o0hie	19	31	.	.	.
cord-332422-s15o0hie	20	1	HCV	HCV	NNP
cord-332422-s15o0hie	20	2	belongs	belong	VBZ
cord-332422-s15o0hie	20	3	to	to	IN
cord-332422-s15o0hie	20	4	the	the	DT
cord-332422-s15o0hie	20	5	genus	genus	NN
cord-332422-s15o0hie	20	6	Hepacivirus	Hepacivirus	NNP
cord-332422-s15o0hie	20	7	in	in	IN
cord-332422-s15o0hie	20	8	the	the	DT
cord-332422-s15o0hie	20	9	Flaviviridae	Flaviviridae	NNP
cord-332422-s15o0hie	20	10	family	family	NN
cord-332422-s15o0hie	20	11	.	.	.
cord-332422-s15o0hie	21	1	It	-PRON-	PRP
cord-332422-s15o0hie	21	2	is	be	VBZ
cord-332422-s15o0hie	21	3	a	a	DT
cord-332422-s15o0hie	21	4	small	small	JJ
cord-332422-s15o0hie	21	5	enveloped	envelop	VBN
cord-332422-s15o0hie	21	6	virus	virus	NN
cord-332422-s15o0hie	21	7	with	with	IN
cord-332422-s15o0hie	21	8	a	a	DT
cord-332422-s15o0hie	21	9	positive	positive	JJ
cord-332422-s15o0hie	21	10	sense	sense	NN
cord-332422-s15o0hie	21	11	single	single	JJ
cord-332422-s15o0hie	21	12	stranded	strand	VBN
cord-332422-s15o0hie	21	13	RNA	RNA	NNP
cord-332422-s15o0hie	21	14	genome	genome	NN
cord-332422-s15o0hie	21	15	of	of	IN
cord-332422-s15o0hie	21	16	9.6	9.6	CD
cord-332422-s15o0hie	21	17	Kb	Kb	NNP
cord-332422-s15o0hie	21	18	.	.	.
cord-332422-s15o0hie	22	1	The	the	DT
cord-332422-s15o0hie	22	2	genome	genome	NN
cord-332422-s15o0hie	22	3	is	be	VBZ
cord-332422-s15o0hie	22	4	translated	translate	VBN
cord-332422-s15o0hie	22	5	as	as	IN
cord-332422-s15o0hie	22	6	a	a	DT
cord-332422-s15o0hie	22	7	polyprotein	polyprotein	NN
cord-332422-s15o0hie	22	8	of	of	IN
cord-332422-s15o0hie	22	9	~3000	~3000	CD
cord-332422-s15o0hie	22	10	amino	amino	NN
cord-332422-s15o0hie	22	11	acids	acid	NNS
cord-332422-s15o0hie	22	12	,	,	,
cord-332422-s15o0hie	22	13	which	which	WDT
cord-332422-s15o0hie	22	14	is	be	VBZ
cord-332422-s15o0hie	22	15	processed	process	VBN
cord-332422-s15o0hie	22	16	during	during	IN
cord-332422-s15o0hie	22	17	translation	translation	NN
cord-332422-s15o0hie	22	18	by	by	IN
cord-332422-s15o0hie	22	19	cellular	cellular	JJ
cord-332422-s15o0hie	22	20	and	and	CC
cord-332422-s15o0hie	22	21	viral	viral	JJ
cord-332422-s15o0hie	22	22	proteases	protease	NNS
cord-332422-s15o0hie	22	23	to	to	TO
cord-332422-s15o0hie	22	24	generate	generate	VB
cord-332422-s15o0hie	22	25	the	the	DT
cord-332422-s15o0hie	22	26	structural	structural	JJ
cord-332422-s15o0hie	22	27	(	(	-LRB-
cord-332422-s15o0hie	22	28	capsid	capsid	NN
cord-332422-s15o0hie	22	29	,	,	,
cord-332422-s15o0hie	22	30	E1	E1	NNP
cord-332422-s15o0hie	22	31	and	and	CC
cord-332422-s15o0hie	22	32	E2	E2	NNP
cord-332422-s15o0hie	22	33	)	)	-RRB-
cord-332422-s15o0hie	22	34	and	and	CC
cord-332422-s15o0hie	22	35	non	non	JJ
cord-332422-s15o0hie	22	36	-	-	JJ
cord-332422-s15o0hie	22	37	structural	structural	JJ
cord-332422-s15o0hie	22	38	proteins	protein	NNS
cord-332422-s15o0hie	22	39	(	(	-LRB-
cord-332422-s15o0hie	22	40	p7	p7	RB
cord-332422-s15o0hie	22	41	,	,	,
cord-332422-s15o0hie	22	42	NS2	NS2	NNP
cord-332422-s15o0hie	22	43	,	,	,
cord-332422-s15o0hie	22	44	NS3	ns3	RB
cord-332422-s15o0hie	22	45	,	,	,
cord-332422-s15o0hie	22	46	NS4A	NS4A	NNP
cord-332422-s15o0hie	22	47	,	,	,
cord-332422-s15o0hie	22	48	NS4B	NS4B	NNP
cord-332422-s15o0hie	22	49	,	,	,
cord-332422-s15o0hie	22	50	NS5A	NS5A	NNP
cord-332422-s15o0hie	22	51	and	and	CC
cord-332422-s15o0hie	22	52	NS5B	NS5B	NNP
cord-332422-s15o0hie	22	53	)	)	-RRB-
cord-332422-s15o0hie	22	54	[	[	-LRB-
cord-332422-s15o0hie	22	55	1	1	CD
cord-332422-s15o0hie	22	56	]	]	-RRB-
cord-332422-s15o0hie	22	57	.	.	.
cord-332422-s15o0hie	23	1	The	the	DT
cord-332422-s15o0hie	23	2	structural	structural	JJ
cord-332422-s15o0hie	23	3	proteins	protein	NNS
cord-332422-s15o0hie	23	4	are	be	VBP
cord-332422-s15o0hie	23	5	components	component	NNS
cord-332422-s15o0hie	23	6	of	of	IN
cord-332422-s15o0hie	23	7	the	the	DT
cord-332422-s15o0hie	23	8	viral	viral	JJ
cord-332422-s15o0hie	23	9	particle	particle	NN
cord-332422-s15o0hie	23	10	which	which	WDT
cord-332422-s15o0hie	23	11	has	have	VBZ
cord-332422-s15o0hie	23	12	the	the	DT
cord-332422-s15o0hie	23	13	peculiar	peculiar	JJ
cord-332422-s15o0hie	23	14	feature	feature	NN
cord-332422-s15o0hie	23	15	of	of	IN
cord-332422-s15o0hie	23	16	being	be	VBG
cord-332422-s15o0hie	23	17	associated	associate	VBN
cord-332422-s15o0hie	23	18	with	with	IN
cord-332422-s15o0hie	23	19	low	low	JJ
cord-332422-s15o0hie	23	20	-	-	:
cord-332422-s15o0hie	23	21	or	or	CC
cord-332422-s15o0hie	23	22	very	very	RB
cord-332422-s15o0hie	23	23	low	low	JJ
cord-332422-s15o0hie	23	24	-	-	HYPH
cord-332422-s15o0hie	23	25	density	density	NN
cord-332422-s15o0hie	23	26	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	23	27	(	(	-LRB-
cord-332422-s15o0hie	23	28	LDL	LDL	NNP
cord-332422-s15o0hie	23	29	or	or	CC
cord-332422-s15o0hie	23	30	VLDL	VLDL	NNP
cord-332422-s15o0hie	23	31	)	)	-RRB-
cord-332422-s15o0hie	23	32	[	[	-LRB-
cord-332422-s15o0hie	23	33	2	2	CD
cord-332422-s15o0hie	23	34	]	]	-RRB-
cord-332422-s15o0hie	23	35	.	.	.
cord-332422-s15o0hie	24	1	For	for	IN
cord-332422-s15o0hie	24	2	many	many	JJ
cord-332422-s15o0hie	24	3	years	year	NNS
cord-332422-s15o0hie	24	4	,	,	,
cord-332422-s15o0hie	24	5	the	the	DT
cord-332422-s15o0hie	24	6	study	study	NN
cord-332422-s15o0hie	24	7	of	of	IN
cord-332422-s15o0hie	24	8	the	the	DT
cord-332422-s15o0hie	24	9	HCV	HCV	NNP
cord-332422-s15o0hie	24	10	life	life	NN
cord-332422-s15o0hie	24	11	cycle	cycle	NN
cord-332422-s15o0hie	24	12	has	have	VBZ
cord-332422-s15o0hie	24	13	been	be	VBN
cord-332422-s15o0hie	24	14	impaired	impair	VBN
cord-332422-s15o0hie	24	15	by	by	IN
cord-332422-s15o0hie	24	16	the	the	DT
cord-332422-s15o0hie	24	17	inability	inability	NN
cord-332422-s15o0hie	24	18	to	to	TO
cord-332422-s15o0hie	24	19	efficiently	efficiently	RB
cord-332422-s15o0hie	24	20	grow	grow	VB
cord-332422-s15o0hie	24	21	HCV	HCV	NNP
cord-332422-s15o0hie	24	22	in	in	IN
cord-332422-s15o0hie	24	23	cell	cell	NN
cord-332422-s15o0hie	24	24	culture	culture	NN
cord-332422-s15o0hie	24	25	.	.	.
cord-332422-s15o0hie	25	1	However	however	RB
cord-332422-s15o0hie	25	2	,	,	,
cord-332422-s15o0hie	25	3	in	in	IN
cord-332422-s15o0hie	25	4	recent	recent	JJ
cord-332422-s15o0hie	25	5	years	year	NNS
cord-332422-s15o0hie	25	6	,	,	,
cord-332422-s15o0hie	25	7	several	several	JJ
cord-332422-s15o0hie	25	8	major	major	JJ
cord-332422-s15o0hie	25	9	advances	advance	NNS
cord-332422-s15o0hie	25	10	have	have	VBP
cord-332422-s15o0hie	25	11	facilitated	facilitate	VBN
cord-332422-s15o0hie	25	12	research	research	NN
cord-332422-s15o0hie	25	13	on	on	IN
cord-332422-s15o0hie	25	14	HCV	HCV	NNP
cord-332422-s15o0hie	25	15	.	.	.
cord-332422-s15o0hie	26	1	Among	among	IN
cord-332422-s15o0hie	26	2	them	-PRON-	PRP
cord-332422-s15o0hie	26	3	,	,	,
cord-332422-s15o0hie	26	4	retroviral	retroviral	NN
cord-332422-s15o0hie	26	5	particles	particle	NNS
cord-332422-s15o0hie	26	6	pseudotyped	pseudotype	VBN
cord-332422-s15o0hie	26	7	with	with	IN
cord-332422-s15o0hie	26	8	HCV	HCV	NNP
cord-332422-s15o0hie	26	9	envelope	envelope	NN
cord-332422-s15o0hie	26	10	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	26	11	,	,	,
cord-332422-s15o0hie	26	12	E1	E1	NNP
cord-332422-s15o0hie	26	13	and	and	CC
cord-332422-s15o0hie	26	14	E2	E2	NNP
cord-332422-s15o0hie	26	15	,	,	,
cord-332422-s15o0hie	26	16	(	(	-LRB-
cord-332422-s15o0hie	26	17	HCVpp	hcvpp	NN
cord-332422-s15o0hie	26	18	)	)	-RRB-
cord-332422-s15o0hie	26	19	were	be	VBD
cord-332422-s15o0hie	26	20	the	the	DT
cord-332422-s15o0hie	26	21	first	first	JJ
cord-332422-s15o0hie	26	22	robust	robust	JJ
cord-332422-s15o0hie	26	23	in	in	FW
cord-332422-s15o0hie	26	24	vitro	vitro	FW
cord-332422-s15o0hie	26	25	assay	assay	NN
cord-332422-s15o0hie	26	26	for	for	IN
cord-332422-s15o0hie	26	27	the	the	DT
cord-332422-s15o0hie	26	28	functional	functional	JJ
cord-332422-s15o0hie	26	29	study	study	NN
cord-332422-s15o0hie	26	30	of	of	IN
cord-332422-s15o0hie	26	31	HCV	HCV	NNP
cord-332422-s15o0hie	26	32	entry	entry	NN
cord-332422-s15o0hie	26	33	[	[	-LRB-
cord-332422-s15o0hie	26	34	3	3	CD
cord-332422-s15o0hie	26	35	]	]	-RRB-
cord-332422-s15o0hie	26	36	.	.	.
cord-332422-s15o0hie	27	1	Following	follow	VBG
cord-332422-s15o0hie	27	2	that	that	IN
cord-332422-s15o0hie	27	3	,	,	,
cord-332422-s15o0hie	27	4	a	a	DT
cord-332422-s15o0hie	27	5	major	major	JJ
cord-332422-s15o0hie	27	6	breakthrough	breakthrough	NN
cord-332422-s15o0hie	27	7	in	in	IN
cord-332422-s15o0hie	27	8	HCV	HCV	NNP
cord-332422-s15o0hie	27	9	research	research	NN
cord-332422-s15o0hie	27	10	was	be	VBD
cord-332422-s15o0hie	27	11	the	the	DT
cord-332422-s15o0hie	27	12	development	development	NN
cord-332422-s15o0hie	27	13	of	of	IN
cord-332422-s15o0hie	27	14	a	a	DT
cord-332422-s15o0hie	27	15	cell	cell	NN
cord-332422-s15o0hie	27	16	culture	culture	NN
cord-332422-s15o0hie	27	17	system	system	NN
cord-332422-s15o0hie	27	18	that	that	WDT
cord-332422-s15o0hie	27	19	allowed	allow	VBD
cord-332422-s15o0hie	27	20	for	for	IN
cord-332422-s15o0hie	27	21	the	the	DT
cord-332422-s15o0hie	27	22	production	production	NN
cord-332422-s15o0hie	27	23	of	of	IN
cord-332422-s15o0hie	27	24	infectious	infectious	JJ
cord-332422-s15o0hie	27	25	particles	particle	NNS
cord-332422-s15o0hie	27	26	(	(	-LRB-
cord-332422-s15o0hie	27	27	HCVcc	HCVcc	NNP
cord-332422-s15o0hie	27	28	)	)	-RRB-
cord-332422-s15o0hie	27	29	[	[	-LRB-
cord-332422-s15o0hie	27	30	4	4	CD
cord-332422-s15o0hie	27	31	]	]	-RRB-
cord-332422-s15o0hie	27	32	.	.	.
cord-332422-s15o0hie	28	1	Hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	28	2	are	be	VBP
cord-332422-s15o0hie	28	3	major	major	JJ
cord-332422-s15o0hie	28	4	target	target	NN
cord-332422-s15o0hie	28	5	cells	cell	NNS
cord-332422-s15o0hie	28	6	of	of	IN
cord-332422-s15o0hie	28	7	HCV	HCV	NNP
cord-332422-s15o0hie	28	8	infection	infection	NN
cord-332422-s15o0hie	28	9	.	.	.
cord-332422-s15o0hie	29	1	The	the	DT
cord-332422-s15o0hie	29	2	liver	liver	NN
cord-332422-s15o0hie	29	3	is	be	VBZ
cord-332422-s15o0hie	29	4	a	a	DT
cord-332422-s15o0hie	29	5	complex	complex	JJ
cord-332422-s15o0hie	29	6	organ	organ	NN
cord-332422-s15o0hie	29	7	,	,	,
cord-332422-s15o0hie	29	8	containing	contain	VBG
cord-332422-s15o0hie	29	9	at	at	IN
cord-332422-s15o0hie	29	10	least	least	JJS
cord-332422-s15o0hie	29	11	a	a	DT
cord-332422-s15o0hie	29	12	dozen	dozen	NN
cord-332422-s15o0hie	29	13	different	different	JJ
cord-332422-s15o0hie	29	14	cell	cell	NN
cord-332422-s15o0hie	29	15	types	type	NNS
cord-332422-s15o0hie	29	16	.	.	.
cord-332422-s15o0hie	30	1	However	however	RB
cord-332422-s15o0hie	30	2	,	,	,
cord-332422-s15o0hie	30	3	70	70	CD
cord-332422-s15o0hie	30	4	to	to	TO
cord-332422-s15o0hie	30	5	80	80	CD
cord-332422-s15o0hie	30	6	%	%	NN
cord-332422-s15o0hie	30	7	of	of	IN
cord-332422-s15o0hie	30	8	the	the	DT
cord-332422-s15o0hie	30	9	liver	liver	NN
cord-332422-s15o0hie	30	10	cell	cell	NN
cord-332422-s15o0hie	30	11	population	population	NN
cord-332422-s15o0hie	30	12	is	be	VBZ
cord-332422-s15o0hie	30	13	composed	compose	VBN
cord-332422-s15o0hie	30	14	of	of	IN
cord-332422-s15o0hie	30	15	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	30	16	that	that	WDT
cord-332422-s15o0hie	30	17	are	be	VBP
cord-332422-s15o0hie	30	18	responsible	responsible	JJ
cord-332422-s15o0hie	30	19	for	for	IN
cord-332422-s15o0hie	30	20	the	the	DT
cord-332422-s15o0hie	30	21	major	major	JJ
cord-332422-s15o0hie	30	22	liver	liver	NN
cord-332422-s15o0hie	30	23	functions	function	NNS
cord-332422-s15o0hie	30	24	such	such	JJ
cord-332422-s15o0hie	30	25	as	as	IN
cord-332422-s15o0hie	30	26	protein	protein	NN
cord-332422-s15o0hie	30	27	synthesis	synthesis	NN
cord-332422-s15o0hie	30	28	,	,	,
cord-332422-s15o0hie	30	29	lipid	lipid	NN
cord-332422-s15o0hie	30	30	and	and	CC
cord-332422-s15o0hie	30	31	carbohydrate	carbohydrate	NN
cord-332422-s15o0hie	30	32	metabolism	metabolism	NN
cord-332422-s15o0hie	30	33	,	,	,
cord-332422-s15o0hie	30	34	bile	bile	NN
cord-332422-s15o0hie	30	35	synthesis	synthesis	NN
cord-332422-s15o0hie	30	36	/	/	SYM
cord-332422-s15o0hie	30	37	secretion	secretion	NN
cord-332422-s15o0hie	30	38	and	and	CC
cord-332422-s15o0hie	30	39	detoxification	detoxification	NN
cord-332422-s15o0hie	30	40	.	.	.
cord-332422-s15o0hie	31	1	To	to	TO
cord-332422-s15o0hie	31	2	function	function	VB
cord-332422-s15o0hie	31	3	in	in	IN
cord-332422-s15o0hie	31	4	this	this	DT
cord-332422-s15o0hie	31	5	capacity	capacity	NN
cord-332422-s15o0hie	31	6	,	,	,
cord-332422-s15o0hie	31	7	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	31	8	express	express	VBP
cord-332422-s15o0hie	31	9	specific	specific	JJ
cord-332422-s15o0hie	31	10	genes	gene	NNS
cord-332422-s15o0hie	31	11	and	and	CC
cord-332422-s15o0hie	31	12	their	-PRON-	PRP$
cord-332422-s15o0hie	31	13	functionality	functionality	NN
cord-332422-s15o0hie	31	14	requires	require	VBZ
cord-332422-s15o0hie	31	15	polarization	polarization	NN
cord-332422-s15o0hie	31	16	with	with	IN
cord-332422-s15o0hie	31	17	separated	separate	VBN
cord-332422-s15o0hie	31	18	apical	apical	JJ
cord-332422-s15o0hie	31	19	and	and	CC
cord-332422-s15o0hie	31	20	basolateral	basolateral	JJ
cord-332422-s15o0hie	31	21	membrane	membrane	NN
cord-332422-s15o0hie	31	22	domains	domain	NNS
cord-332422-s15o0hie	31	23	,	,	,
cord-332422-s15o0hie	31	24	which	which	WDT
cord-332422-s15o0hie	31	25	differ	differ	VBP
cord-332422-s15o0hie	31	26	in	in	IN
cord-332422-s15o0hie	31	27	their	-PRON-	PRP$
cord-332422-s15o0hie	31	28	protein	protein	NN
cord-332422-s15o0hie	31	29	and	and	CC
cord-332422-s15o0hie	31	30	lipidic	lipidic	NNP
cord-332422-s15o0hie	31	31	composition	composition	NN
cord-332422-s15o0hie	31	32	.	.	.
cord-332422-s15o0hie	32	1	It	-PRON-	PRP
cord-332422-s15o0hie	32	2	is	be	VBZ
cord-332422-s15o0hie	32	3	therefore	therefore	RB
cord-332422-s15o0hie	32	4	very	very	RB
cord-332422-s15o0hie	32	5	likely	likely	JJ
cord-332422-s15o0hie	32	6	that	that	IN
cord-332422-s15o0hie	32	7	the	the	DT
cord-332422-s15o0hie	32	8	specific	specific	JJ
cord-332422-s15o0hie	32	9	architecture	architecture	NN
cord-332422-s15o0hie	32	10	of	of	IN
cord-332422-s15o0hie	32	11	the	the	DT
cord-332422-s15o0hie	32	12	liver	liver	NN
cord-332422-s15o0hie	32	13	plays	play	VBZ
cord-332422-s15o0hie	32	14	a	a	DT
cord-332422-s15o0hie	32	15	major	major	JJ
cord-332422-s15o0hie	32	16	role	role	NN
cord-332422-s15o0hie	32	17	in	in	IN
cord-332422-s15o0hie	32	18	HCV	HCV	NNP
cord-332422-s15o0hie	32	19	propagation	propagation	NN
cord-332422-s15o0hie	32	20	within	within	IN
cord-332422-s15o0hie	32	21	this	this	DT
cord-332422-s15o0hie	32	22	organ	organ	NN
cord-332422-s15o0hie	32	23	.	.	.
cord-332422-s15o0hie	33	1	The	the	DT
cord-332422-s15o0hie	33	2	viral	viral	JJ
cord-332422-s15o0hie	33	3	entry	entry	NN
cord-332422-s15o0hie	33	4	process	process	NN
cord-332422-s15o0hie	33	5	relies	rely	VBZ
cord-332422-s15o0hie	33	6	on	on	IN
cord-332422-s15o0hie	33	7	a	a	DT
cord-332422-s15o0hie	33	8	fine	fine	JJ
cord-332422-s15o0hie	33	9	interplay	interplay	NN
cord-332422-s15o0hie	33	10	between	between	IN
cord-332422-s15o0hie	33	11	the	the	DT
cord-332422-s15o0hie	33	12	virion	virion	NN
cord-332422-s15o0hie	33	13	and	and	CC
cord-332422-s15o0hie	33	14	the	the	DT
cord-332422-s15o0hie	33	15	host	host	NN
cord-332422-s15o0hie	33	16	cell	cell	NN
cord-332422-s15o0hie	33	17	.	.	.
cord-332422-s15o0hie	34	1	Infection	infection	NN
cord-332422-s15o0hie	34	2	is	be	VBZ
cord-332422-s15o0hie	34	3	initiated	initiate	VBN
cord-332422-s15o0hie	34	4	by	by	IN
cord-332422-s15o0hie	34	5	the	the	DT
cord-332422-s15o0hie	34	6	interaction	interaction	NN
cord-332422-s15o0hie	34	7	of	of	IN
cord-332422-s15o0hie	34	8	the	the	DT
cord-332422-s15o0hie	34	9	viral	viral	JJ
cord-332422-s15o0hie	34	10	particle	particle	NN
cord-332422-s15o0hie	34	11	with	with	IN
cord-332422-s15o0hie	34	12	specific	specific	JJ
cord-332422-s15o0hie	34	13	proteins	protein	NNS
cord-332422-s15o0hie	34	14	on	on	IN
cord-332422-s15o0hie	34	15	the	the	DT
cord-332422-s15o0hie	34	16	cell	cell	NN
cord-332422-s15o0hie	34	17	surface	surface	NN
cord-332422-s15o0hie	34	18	.	.	.
cord-332422-s15o0hie	35	1	These	these	DT
cord-332422-s15o0hie	35	2	proteins	protein	NNS
cord-332422-s15o0hie	35	3	belong	belong	VBP
cord-332422-s15o0hie	35	4	to	to	IN
cord-332422-s15o0hie	35	5	two	two	CD
cord-332422-s15o0hie	35	6	general	general	JJ
cord-332422-s15o0hie	35	7	categories	category	NNS
cord-332422-s15o0hie	35	8	which	which	WDT
cord-332422-s15o0hie	35	9	are	be	VBP
cord-332422-s15o0hie	35	10	classified	classify	VBN
cord-332422-s15o0hie	35	11	based	base	VBN
cord-332422-s15o0hie	35	12	on	on	IN
cord-332422-s15o0hie	35	13	the	the	DT
cord-332422-s15o0hie	35	14	functional	functional	JJ
cord-332422-s15o0hie	35	15	consequences	consequence	NNS
cord-332422-s15o0hie	35	16	of	of	IN
cord-332422-s15o0hie	35	17	their	-PRON-	PRP$
cord-332422-s15o0hie	35	18	interaction	interaction	NN
cord-332422-s15o0hie	35	19	:	:	:
cord-332422-s15o0hie	35	20	attachment	attachment	NN
cord-332422-s15o0hie	35	21	factors	factor	NNS
cord-332422-s15o0hie	35	22	and	and	CC
cord-332422-s15o0hie	35	23	receptors	receptor	NNS
cord-332422-s15o0hie	35	24	.	.	.
cord-332422-s15o0hie	36	1	Attachment	attachment	NN
cord-332422-s15o0hie	36	2	factors	factor	NNS
cord-332422-s15o0hie	36	3	serve	serve	VBP
cord-332422-s15o0hie	36	4	to	to	TO
cord-332422-s15o0hie	36	5	bind	bind	VB
cord-332422-s15o0hie	36	6	and	and	CC
cord-332422-s15o0hie	36	7	concentrate	concentrate	VB
cord-332422-s15o0hie	36	8	particles	particle	NNS
cord-332422-s15o0hie	36	9	at	at	IN
cord-332422-s15o0hie	36	10	the	the	DT
cord-332422-s15o0hie	36	11	cell	cell	NN
cord-332422-s15o0hie	36	12	surface	surface	NN
cord-332422-s15o0hie	36	13	.	.	.
cord-332422-s15o0hie	37	1	Usually	usually	RB
cord-332422-s15o0hie	37	2	,	,	,
cord-332422-s15o0hie	37	3	these	these	DT
cord-332422-s15o0hie	37	4	interactions	interaction	NNS
cord-332422-s15o0hie	37	5	have	have	VBP
cord-332422-s15o0hie	37	6	a	a	DT
cord-332422-s15o0hie	37	7	rather	rather	RB
cord-332422-s15o0hie	37	8	low	low	JJ
cord-332422-s15o0hie	37	9	specificity	specificity	NN
cord-332422-s15o0hie	37	10	.	.	.
cord-332422-s15o0hie	38	1	On	on	IN
cord-332422-s15o0hie	38	2	the	the	DT
cord-332422-s15o0hie	38	3	other	other	JJ
cord-332422-s15o0hie	38	4	hand	hand	NN
cord-332422-s15o0hie	38	5	,	,	,
cord-332422-s15o0hie	38	6	receptors	receptor	NNS
cord-332422-s15o0hie	38	7	actively	actively	RB
cord-332422-s15o0hie	38	8	promote	promote	VBP
cord-332422-s15o0hie	38	9	virus	virus	NN
cord-332422-s15o0hie	38	10	entry	entry	NN
cord-332422-s15o0hie	38	11	by	by	IN
cord-332422-s15o0hie	38	12	inducing	induce	VBG
cord-332422-s15o0hie	38	13	conformational	conformational	JJ
cord-332422-s15o0hie	38	14	changes	change	NNS
cord-332422-s15o0hie	38	15	of	of	IN
cord-332422-s15o0hie	38	16	the	the	DT
cord-332422-s15o0hie	38	17	viral	viral	JJ
cord-332422-s15o0hie	38	18	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	38	19	and/or	and/or	CC
cord-332422-s15o0hie	38	20	by	by	IN
cord-332422-s15o0hie	38	21	activating	activate	VBG
cord-332422-s15o0hie	38	22	signaling	signal	VBG
cord-332422-s15o0hie	38	23	pathways	pathway	NNS
cord-332422-s15o0hie	38	24	necessary	necessary	JJ
cord-332422-s15o0hie	38	25	for	for	IN
cord-332422-s15o0hie	38	26	internalization	internalization	NN
cord-332422-s15o0hie	38	27	of	of	IN
cord-332422-s15o0hie	38	28	the	the	DT
cord-332422-s15o0hie	38	29	virion	virion	NN
cord-332422-s15o0hie	38	30	.	.	.
cord-332422-s15o0hie	39	1	Currently	currently	RB
cord-332422-s15o0hie	39	2	,	,	,
cord-332422-s15o0hie	39	3	HCV	HCV	NNP
cord-332422-s15o0hie	39	4	entry	entry	NN
cord-332422-s15o0hie	39	5	is	be	VBZ
cord-332422-s15o0hie	39	6	viewed	view	VBN
cord-332422-s15o0hie	39	7	as	as	IN
cord-332422-s15o0hie	39	8	a	a	DT
cord-332422-s15o0hie	39	9	complex	complex	JJ
cord-332422-s15o0hie	39	10	multistep	multistep	NN
cord-332422-s15o0hie	39	11	process	process	NN
cord-332422-s15o0hie	39	12	as	as	IN
cord-332422-s15o0hie	39	13	at	at	RB
cord-332422-s15o0hie	39	14	least	least	JJS
cord-332422-s15o0hie	39	15	four	four	CD
cord-332422-s15o0hie	39	16	specific	specific	JJ
cord-332422-s15o0hie	39	17	cellular	cellular	JJ
cord-332422-s15o0hie	39	18	factors	factor	NNS
cord-332422-s15o0hie	39	19	have	have	VBP
cord-332422-s15o0hie	39	20	been	be	VBN
cord-332422-s15o0hie	39	21	shown	show	VBN
cord-332422-s15o0hie	39	22	to	to	TO
cord-332422-s15o0hie	39	23	be	be	VB
cord-332422-s15o0hie	39	24	essential	essential	JJ
cord-332422-s15o0hie	39	25	for	for	IN
cord-332422-s15o0hie	39	26	HCV	HCV	NNP
cord-332422-s15o0hie	39	27	entry	entry	NN
cord-332422-s15o0hie	39	28	.	.	.
cord-332422-s15o0hie	40	1	These	these	DT
cord-332422-s15o0hie	40	2	molecules	molecule	NNS
cord-332422-s15o0hie	40	3	are	be	VBP
cord-332422-s15o0hie	40	4	the	the	DT
cord-332422-s15o0hie	40	5	scavenger	scavenger	NN
cord-332422-s15o0hie	40	6	receptor	receptor	NN
cord-332422-s15o0hie	40	7	class	class	NN
cord-332422-s15o0hie	40	8	B	b	NN
cord-332422-s15o0hie	40	9	type	type	NN
cord-332422-s15o0hie	40	10	I	-PRON-	PRP
cord-332422-s15o0hie	40	11	(	(	-LRB-
cord-332422-s15o0hie	40	12	SRB1	SRB1	NNP
cord-332422-s15o0hie	40	13	)	)	-RRB-
cord-332422-s15o0hie	40	14	,	,	,
cord-332422-s15o0hie	40	15	the	the	DT
cord-332422-s15o0hie	40	16	tetraspanin	tetraspanin	NNP
cord-332422-s15o0hie	40	17	CD81	CD81	NNP
cord-332422-s15o0hie	40	18	and	and	CC
cord-332422-s15o0hie	40	19	tight	tight	JJ
cord-332422-s15o0hie	40	20	junction	junction	NN
cord-332422-s15o0hie	40	21	proteins	protein	NNS
cord-332422-s15o0hie	40	22	,	,	,
cord-332422-s15o0hie	40	23	Claudin-1	Claudin-1	NNP
cord-332422-s15o0hie	40	24	(	(	-LRB-
cord-332422-s15o0hie	40	25	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	40	26	)	)	-RRB-
cord-332422-s15o0hie	40	27	and	and	CC
cord-332422-s15o0hie	40	28	Occludin	Occludin	NNP
cord-332422-s15o0hie	40	29	(	(	-LRB-
cord-332422-s15o0hie	40	30	OCLN	OCLN	NNP
cord-332422-s15o0hie	40	31	)	)	-RRB-
cord-332422-s15o0hie	40	32	(	(	-LRB-
cord-332422-s15o0hie	40	33	reviewed	review	VBN
cord-332422-s15o0hie	40	34	in	in	IN
cord-332422-s15o0hie	40	35	[	[	-LRB-
cord-332422-s15o0hie	40	36	5	5	CD
cord-332422-s15o0hie	40	37	]	]	-RRB-
cord-332422-s15o0hie	40	38	)	)	-RRB-
cord-332422-s15o0hie	40	39	.	.	.
cord-332422-s15o0hie	41	1	In	in	IN
cord-332422-s15o0hie	41	2	this	this	DT
cord-332422-s15o0hie	41	3	review	review	NN
cord-332422-s15o0hie	41	4	,	,	,
cord-332422-s15o0hie	41	5	we	-PRON-	PRP
cord-332422-s15o0hie	41	6	will	will	MD
cord-332422-s15o0hie	41	7	first	first	RB
cord-332422-s15o0hie	41	8	address	address	VB
cord-332422-s15o0hie	41	9	what	what	WP
cord-332422-s15o0hie	41	10	we	-PRON-	PRP
cord-332422-s15o0hie	41	11	know	know	VBP
cord-332422-s15o0hie	41	12	of	of	IN
cord-332422-s15o0hie	41	13	the	the	DT
cord-332422-s15o0hie	41	14	composition	composition	NN
cord-332422-s15o0hie	41	15	of	of	IN
cord-332422-s15o0hie	41	16	the	the	DT
cord-332422-s15o0hie	41	17	virion	virion	NN
cord-332422-s15o0hie	41	18	that	that	WDT
cord-332422-s15o0hie	41	19	may	may	MD
cord-332422-s15o0hie	41	20	be	be	VB
cord-332422-s15o0hie	41	21	of	of	IN
cord-332422-s15o0hie	41	22	significance	significance	NN
cord-332422-s15o0hie	41	23	for	for	IN
cord-332422-s15o0hie	41	24	viral	viral	JJ
cord-332422-s15o0hie	41	25	entry	entry	NN
cord-332422-s15o0hie	41	26	,	,	,
cord-332422-s15o0hie	41	27	then	then	RB
cord-332422-s15o0hie	41	28	the	the	DT
cord-332422-s15o0hie	41	29	host	host	NN
cord-332422-s15o0hie	41	30	entry	entry	NN
cord-332422-s15o0hie	41	31	factors	factor	NNS
cord-332422-s15o0hie	41	32	required	require	VBN
cord-332422-s15o0hie	41	33	for	for	IN
cord-332422-s15o0hie	41	34	HCV	HCV	NNP
cord-332422-s15o0hie	41	35	entry	entry	NN
cord-332422-s15o0hie	41	36	and	and	CC
cord-332422-s15o0hie	41	37	we	-PRON-	PRP
cord-332422-s15o0hie	41	38	will	will	MD
cord-332422-s15o0hie	41	39	summarize	summarize	VB
cord-332422-s15o0hie	41	40	current	current	JJ
cord-332422-s15o0hie	41	41	knowledge	knowledge	NN
cord-332422-s15o0hie	41	42	of	of	IN
cord-332422-s15o0hie	41	43	the	the	DT
cord-332422-s15o0hie	41	44	mechanisms	mechanism	NNS
cord-332422-s15o0hie	41	45	of	of	IN
cord-332422-s15o0hie	41	46	HCV	HCV	NNP
cord-332422-s15o0hie	41	47	entry	entry	NN
cord-332422-s15o0hie	41	48	.	.	.
cord-332422-s15o0hie	42	1	The	the	DT
cord-332422-s15o0hie	42	2	HCV	HCV	NNP
cord-332422-s15o0hie	42	3	RNA	RNA	NNP
cord-332422-s15o0hie	42	4	genome	genome	NN
cord-332422-s15o0hie	42	5	,	,	,
cord-332422-s15o0hie	42	6	core	core	NN
cord-332422-s15o0hie	42	7	and	and	CC
cord-332422-s15o0hie	42	8	envelope	envelope	NN
cord-332422-s15o0hie	42	9	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	42	10	,	,	,
cord-332422-s15o0hie	42	11	E1	E1	NNP
cord-332422-s15o0hie	42	12	and	and	CC
cord-332422-s15o0hie	42	13	E2	E2	NNP
cord-332422-s15o0hie	42	14	,	,	,
cord-332422-s15o0hie	42	15	are	be	VBP
cord-332422-s15o0hie	42	16	the	the	DT
cord-332422-s15o0hie	42	17	known	know	VBN
cord-332422-s15o0hie	42	18	viral	viral	JJ
cord-332422-s15o0hie	42	19	components	component	NNS
cord-332422-s15o0hie	42	20	of	of	IN
cord-332422-s15o0hie	42	21	the	the	DT
cord-332422-s15o0hie	42	22	virion	virion	NN
cord-332422-s15o0hie	42	23	.	.	.
cord-332422-s15o0hie	43	1	The	the	DT
cord-332422-s15o0hie	43	2	HCV	HCV	NNP
cord-332422-s15o0hie	43	3	genome	genome	NN
cord-332422-s15o0hie	43	4	interacts	interact	VBZ
cord-332422-s15o0hie	43	5	with	with	IN
cord-332422-s15o0hie	43	6	the	the	DT
cord-332422-s15o0hie	43	7	core	core	NN
cord-332422-s15o0hie	43	8	to	to	TO
cord-332422-s15o0hie	43	9	form	form	VB
cord-332422-s15o0hie	43	10	the	the	DT
cord-332422-s15o0hie	43	11	nucleocapsid	nucleocapsid	NN
cord-332422-s15o0hie	43	12	that	that	WDT
cord-332422-s15o0hie	43	13	is	be	VBZ
cord-332422-s15o0hie	43	14	surrounded	surround	VBN
cord-332422-s15o0hie	43	15	by	by	IN
cord-332422-s15o0hie	43	16	a	a	DT
cord-332422-s15o0hie	43	17	host	host	NN
cord-332422-s15o0hie	43	18	derived	derive	VBN
cord-332422-s15o0hie	43	19	lipid	lipid	NN
cord-332422-s15o0hie	43	20	membrane	membrane	NN
cord-332422-s15o0hie	43	21	,	,	,
cord-332422-s15o0hie	43	22	called	call	VBD
cord-332422-s15o0hie	43	23	the	the	DT
cord-332422-s15o0hie	43	24	viral	viral	JJ
cord-332422-s15o0hie	43	25	envelope	envelope	NN
cord-332422-s15o0hie	43	26	,	,	,
cord-332422-s15o0hie	43	27	in	in	IN
cord-332422-s15o0hie	43	28	which	which	WDT
cord-332422-s15o0hie	43	29	are	be	VBP
cord-332422-s15o0hie	43	30	anchored	anchor	VBN
cord-332422-s15o0hie	43	31	the	the	DT
cord-332422-s15o0hie	43	32	envelope	envelope	NN
cord-332422-s15o0hie	43	33	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	43	34	.	.	.
cord-332422-s15o0hie	44	1	HCV	HCV	NNP
cord-332422-s15o0hie	44	2	envelope	envelope	NN
cord-332422-s15o0hie	44	3	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	44	4	are	be	VBP
cord-332422-s15o0hie	44	5	key	key	JJ
cord-332422-s15o0hie	44	6	determinants	determinant	NNS
cord-332422-s15o0hie	44	7	of	of	IN
cord-332422-s15o0hie	44	8	HCV	HCV	NNP
cord-332422-s15o0hie	44	9	entry	entry	NN
cord-332422-s15o0hie	44	10	with	with	IN
cord-332422-s15o0hie	44	11	a	a	DT
cord-332422-s15o0hie	44	12	role	role	NN
cord-332422-s15o0hie	44	13	in	in	IN
cord-332422-s15o0hie	44	14	receptor	receptor	NN
cord-332422-s15o0hie	44	15	binding	binding	NN
cord-332422-s15o0hie	44	16	and	and	CC
cord-332422-s15o0hie	44	17	in	in	IN
cord-332422-s15o0hie	44	18	mediating	mediate	VBG
cord-332422-s15o0hie	44	19	the	the	DT
cord-332422-s15o0hie	44	20	fusion	fusion	NN
cord-332422-s15o0hie	44	21	process	process	NN
cord-332422-s15o0hie	44	22	between	between	IN
cord-332422-s15o0hie	44	23	the	the	DT
cord-332422-s15o0hie	44	24	viral	viral	JJ
cord-332422-s15o0hie	44	25	envelope	envelope	NN
cord-332422-s15o0hie	44	26	and	and	CC
cord-332422-s15o0hie	44	27	an	an	DT
cord-332422-s15o0hie	44	28	endosomal	endosomal	NNP
cord-332422-s15o0hie	44	29	host	host	NN
cord-332422-s15o0hie	44	30	cell	cell	NN
cord-332422-s15o0hie	44	31	membrane	membrane	NN
cord-332422-s15o0hie	44	32	.	.	.
cord-332422-s15o0hie	45	1	Their	-PRON-	PRP$
cord-332422-s15o0hie	45	2	biogenesis	biogenesis	NN
cord-332422-s15o0hie	45	3	has	have	VBZ
cord-332422-s15o0hie	45	4	been	be	VBN
cord-332422-s15o0hie	45	5	extensively	extensively	RB
cord-332422-s15o0hie	45	6	characterized	characterize	VBN
cord-332422-s15o0hie	45	7	in	in	IN
cord-332422-s15o0hie	45	8	recombinant	recombinant	JJ
cord-332422-s15o0hie	45	9	systems	system	NNS
cord-332422-s15o0hie	45	10	[	[	-LRB-
cord-332422-s15o0hie	45	11	6	6	CD
cord-332422-s15o0hie	45	12	]	]	-RRB-
cord-332422-s15o0hie	45	13	.	.	.
cord-332422-s15o0hie	46	1	E1	E1	NNP
cord-332422-s15o0hie	46	2	and	and	CC
cord-332422-s15o0hie	46	3	E2	E2	NNP
cord-332422-s15o0hie	46	4	are	be	VBP
cord-332422-s15o0hie	46	5	heavily	heavily	RB
cord-332422-s15o0hie	46	6	N	n	CD
cord-332422-s15o0hie	46	7	-	-	HYPH
cord-332422-s15o0hie	46	8	glycosylated	glycosylated	JJ
cord-332422-s15o0hie	46	9	type	type	NN
cord-332422-s15o0hie	46	10	I	-PRON-	PRP
cord-332422-s15o0hie	46	11	transmembrane	transmembrane	NN
cord-332422-s15o0hie	46	12	proteins	protein	NNS
cord-332422-s15o0hie	46	13	which	which	WDT
cord-332422-s15o0hie	46	14	form	form	VBP
cord-332422-s15o0hie	46	15	a	a	DT
cord-332422-s15o0hie	46	16	noncovalent	noncovalent	NN
cord-332422-s15o0hie	46	17	heterodimer	heterodimer	NN
cord-332422-s15o0hie	46	18	.	.	.
cord-332422-s15o0hie	47	1	However	however	RB
cord-332422-s15o0hie	47	2	,	,	,
cord-332422-s15o0hie	47	3	it	-PRON-	PRP
cord-332422-s15o0hie	47	4	has	have	VBZ
cord-332422-s15o0hie	47	5	recently	recently	RB
cord-332422-s15o0hie	47	6	been	be	VBN
cord-332422-s15o0hie	47	7	shown	show	VBN
cord-332422-s15o0hie	47	8	that	that	IN
cord-332422-s15o0hie	47	9	HCV	HCV	NNP
cord-332422-s15o0hie	47	10	envelope	envelope	NN
cord-332422-s15o0hie	47	11	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	47	12	form	form	VBP
cord-332422-s15o0hie	47	13	large	large	JJ
cord-332422-s15o0hie	47	14	covalent	covalent	JJ
cord-332422-s15o0hie	47	15	complexes	complex	NNS
cord-332422-s15o0hie	47	16	stabilized	stabilize	VBN
cord-332422-s15o0hie	47	17	by	by	IN
cord-332422-s15o0hie	47	18	disulfide	disulfide	JJ
cord-332422-s15o0hie	47	19	bonds	bond	NNS
cord-332422-s15o0hie	47	20	on	on	IN
cord-332422-s15o0hie	47	21	secreted	secrete	VBN
cord-332422-s15o0hie	47	22	viral	viral	JJ
cord-332422-s15o0hie	47	23	particles	particle	NNS
cord-332422-s15o0hie	47	24	[	[	-LRB-
cord-332422-s15o0hie	47	25	7	7	CD
cord-332422-s15o0hie	47	26	]	]	-RRB-
cord-332422-s15o0hie	47	27	.	.	.
cord-332422-s15o0hie	48	1	The	the	DT
cord-332422-s15o0hie	48	2	presence	presence	NN
cord-332422-s15o0hie	48	3	of	of	IN
cord-332422-s15o0hie	48	4	disulfide	disulfide	JJ
cord-332422-s15o0hie	48	5	bridges	bridge	NNS
cord-332422-s15o0hie	48	6	between	between	IN
cord-332422-s15o0hie	48	7	HCV	HCV	NNP
cord-332422-s15o0hie	48	8	envelope	envelope	NN
cord-332422-s15o0hie	48	9	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	48	10	suggests	suggest	VBZ
cord-332422-s15o0hie	48	11	that	that	IN
cord-332422-s15o0hie	48	12	lateral	lateral	JJ
cord-332422-s15o0hie	48	13	protein	protein	NN
cord-332422-s15o0hie	48	14	-	-	HYPH
cord-332422-s15o0hie	48	15	protein	protein	NN
cord-332422-s15o0hie	48	16	interactions	interaction	NNS
cord-332422-s15o0hie	48	17	assisted	assist	VBN
cord-332422-s15o0hie	48	18	by	by	IN
cord-332422-s15o0hie	48	19	disulfidebond	disulfidebond	NNP
cord-332422-s15o0hie	48	20	formation	formation	NN
cord-332422-s15o0hie	48	21	might	may	MD
cord-332422-s15o0hie	48	22	play	play	VB
cord-332422-s15o0hie	48	23	an	an	DT
cord-332422-s15o0hie	48	24	active	active	JJ
cord-332422-s15o0hie	48	25	role	role	NN
cord-332422-s15o0hie	48	26	during	during	IN
cord-332422-s15o0hie	48	27	the	the	DT
cord-332422-s15o0hie	48	28	budding	budding	JJ
cord-332422-s15o0hie	48	29	process	process	NN
cord-332422-s15o0hie	48	30	of	of	IN
cord-332422-s15o0hie	48	31	HCV	HCV	NNP
cord-332422-s15o0hie	48	32	particles	particle	NNS
cord-332422-s15o0hie	48	33	.	.	.
cord-332422-s15o0hie	49	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	49	2	,	,	,
cord-332422-s15o0hie	49	3	functional	functional	JJ
cord-332422-s15o0hie	49	4	non	non	JJ
cord-332422-s15o0hie	49	5	-	-	JJ
cord-332422-s15o0hie	49	6	infectious	infectious	JJ
cord-332422-s15o0hie	49	7	and	and	CC
cord-332422-s15o0hie	49	8	capsidless	capsidless	NN
cord-332422-s15o0hie	49	9	structures	structure	NNS
cord-332422-s15o0hie	49	10	,	,	,
cord-332422-s15o0hie	49	11	called	call	VBN
cord-332422-s15o0hie	49	12	subviral	subviral	JJ
cord-332422-s15o0hie	49	13	particles	particle	NNS
cord-332422-s15o0hie	49	14	,	,	,
cord-332422-s15o0hie	49	15	can	can	MD
cord-332422-s15o0hie	49	16	be	be	VB
cord-332422-s15o0hie	49	17	produced	produce	VBN
cord-332422-s15o0hie	49	18	when	when	WRB
cord-332422-s15o0hie	49	19	the	the	DT
cord-332422-s15o0hie	49	20	HCV	HCV	NNP
cord-332422-s15o0hie	49	21	envelope	envelope	NN
cord-332422-s15o0hie	49	22	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	49	23	are	be	VBP
cord-332422-s15o0hie	49	24	expressed	express	VBN
cord-332422-s15o0hie	49	25	alone	alone	JJ
cord-332422-s15o0hie	49	26	in	in	IN
cord-332422-s15o0hie	49	27	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	49	28	producing	produce	VBG
cord-332422-s15o0hie	49	29	cell	cell	NN
cord-332422-s15o0hie	49	30	lines	line	NNS
cord-332422-s15o0hie	49	31	[	[	-LRB-
cord-332422-s15o0hie	49	32	8	8	CD
cord-332422-s15o0hie	49	33	]	]	-RRB-
cord-332422-s15o0hie	49	34	,	,	,
cord-332422-s15o0hie	49	35	supporting	support	VBG
cord-332422-s15o0hie	49	36	the	the	DT
cord-332422-s15o0hie	49	37	idea	idea	NN
cord-332422-s15o0hie	49	38	that	that	IN
cord-332422-s15o0hie	49	39	HCV	HCV	NNP
cord-332422-s15o0hie	49	40	envelope	envelope	NN
cord-332422-s15o0hie	49	41	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	49	42	play	play	VBP
cord-332422-s15o0hie	49	43	an	an	DT
cord-332422-s15o0hie	49	44	active	active	JJ
cord-332422-s15o0hie	49	45	role	role	NN
cord-332422-s15o0hie	49	46	during	during	IN
cord-332422-s15o0hie	49	47	the	the	DT
cord-332422-s15o0hie	49	48	budding	budding	JJ
cord-332422-s15o0hie	49	49	process	process	NN
cord-332422-s15o0hie	49	50	.	.	.
cord-332422-s15o0hie	50	1	The	the	DT
cord-332422-s15o0hie	50	2	secondary	secondary	JJ
cord-332422-s15o0hie	50	3	and	and	CC
cord-332422-s15o0hie	50	4	tertiary	tertiary	JJ
cord-332422-s15o0hie	50	5	structures	structure	NNS
cord-332422-s15o0hie	50	6	of	of	IN
cord-332422-s15o0hie	50	7	envelope	envelope	NN
cord-332422-s15o0hie	50	8	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	50	9	are	be	VBP
cord-332422-s15o0hie	50	10	proposed	propose	VBN
cord-332422-s15o0hie	50	11	to	to	TO
cord-332422-s15o0hie	50	12	be	be	VB
cord-332422-s15o0hie	50	13	similar	similar	JJ
cord-332422-s15o0hie	50	14	among	among	IN
cord-332422-s15o0hie	50	15	the	the	DT
cord-332422-s15o0hie	50	16	members	member	NNS
cord-332422-s15o0hie	50	17	of	of	IN
cord-332422-s15o0hie	50	18	the	the	DT
cord-332422-s15o0hie	50	19	Flaviviridae	Flaviviridae	NNP
cord-332422-s15o0hie	50	20	family	family	NN
cord-332422-s15o0hie	50	21	,	,	,
cord-332422-s15o0hie	50	22	suggesting	suggest	VBG
cord-332422-s15o0hie	50	23	that	that	IN
cord-332422-s15o0hie	50	24	HCV	HCV	NNP
cord-332422-s15o0hie	50	25	envelope	envelope	NN
cord-332422-s15o0hie	50	26	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	50	27	belong	belong	VBP
cord-332422-s15o0hie	50	28	to	to	IN
cord-332422-s15o0hie	50	29	class	class	NN
cord-332422-s15o0hie	50	30	II	II	NNP
cord-332422-s15o0hie	50	31	fusion	fusion	NN
cord-332422-s15o0hie	50	32	proteins	protein	NNS
cord-332422-s15o0hie	50	33	[	[	-LRB-
cord-332422-s15o0hie	50	34	9	9	CD
cord-332422-s15o0hie	50	35	,	,	,
cord-332422-s15o0hie	50	36	10	10	CD
cord-332422-s15o0hie	50	37	]	]	-RRB-
cord-332422-s15o0hie	50	38	.	.	.
cord-332422-s15o0hie	51	1	Recently	recently	RB
cord-332422-s15o0hie	51	2	,	,	,
cord-332422-s15o0hie	51	3	the	the	DT
cord-332422-s15o0hie	51	4	identification	identification	NN
cord-332422-s15o0hie	51	5	of	of	IN
cord-332422-s15o0hie	51	6	9	9	CD
cord-332422-s15o0hie	51	7	intramolecular	intramolecular	JJ
cord-332422-s15o0hie	51	8	disulfide	disulfide	JJ
cord-332422-s15o0hie	51	9	bonds	bond	NNS
cord-332422-s15o0hie	51	10	in	in	IN
cord-332422-s15o0hie	51	11	soluble	soluble	JJ
cord-332422-s15o0hie	51	12	E2	E2	NNP
cord-332422-s15o0hie	51	13	has	have	VBZ
cord-332422-s15o0hie	51	14	shed	shed	VBN
cord-332422-s15o0hie	51	15	light	light	NN
cord-332422-s15o0hie	51	16	on	on	IN
cord-332422-s15o0hie	51	17	its	-PRON-	PRP$
cord-332422-s15o0hie	51	18	structure	structure	NN
cord-332422-s15o0hie	51	19	[	[	-LRB-
cord-332422-s15o0hie	51	20	11	11	CD
cord-332422-s15o0hie	51	21	]	]	-RRB-
cord-332422-s15o0hie	51	22	.	.	.
cord-332422-s15o0hie	52	1	By	by	IN
cord-332422-s15o0hie	52	2	compiling	compile	VBG
cord-332422-s15o0hie	52	3	these	these	DT
cord-332422-s15o0hie	52	4	results	result	NNS
cord-332422-s15o0hie	52	5	with	with	IN
cord-332422-s15o0hie	52	6	various	various	JJ
cord-332422-s15o0hie	52	7	data	datum	NNS
cord-332422-s15o0hie	52	8	relevant	relevant	JJ
cord-332422-s15o0hie	52	9	to	to	IN
cord-332422-s15o0hie	52	10	E2	E2	NNP
cord-332422-s15o0hie	52	11	structure	structure	NN
cord-332422-s15o0hie	52	12	and	and	CC
cord-332422-s15o0hie	52	13	functionality	functionality	NN
cord-332422-s15o0hie	52	14	,	,	,
cord-332422-s15o0hie	52	15	Krey	Krey	NNP
cord-332422-s15o0hie	52	16	et	et	NNP
cord-332422-s15o0hie	52	17	al	al	NNP
cord-332422-s15o0hie	52	18	.	.	NNP
cord-332422-s15o0hie	52	19	proposed	propose	VBD
cord-332422-s15o0hie	52	20	a	a	DT
cord-332422-s15o0hie	52	21	model	model	NN
cord-332422-s15o0hie	52	22	for	for	IN
cord-332422-s15o0hie	52	23	the	the	DT
cord-332422-s15o0hie	52	24	tertiary	tertiary	JJ
cord-332422-s15o0hie	52	25	organization	organization	NN
cord-332422-s15o0hie	52	26	of	of	IN
cord-332422-s15o0hie	52	27	E2	E2	NNP
cord-332422-s15o0hie	52	28	,	,	,
cord-332422-s15o0hie	52	29	which	which	WDT
cord-332422-s15o0hie	52	30	is	be	VBZ
cord-332422-s15o0hie	52	31	consistent	consistent	JJ
cord-332422-s15o0hie	52	32	with	with	IN
cord-332422-s15o0hie	52	33	the	the	DT
cord-332422-s15o0hie	52	34	structure	structure	NN
cord-332422-s15o0hie	52	35	of	of	IN
cord-332422-s15o0hie	52	36	class	class	NN
cord-332422-s15o0hie	52	37	II	II	NNP
cord-332422-s15o0hie	52	38	fusion	fusion	NN
cord-332422-s15o0hie	52	39	protein	protein	NN
cord-332422-s15o0hie	52	40	(	(	-LRB-
cord-332422-s15o0hie	52	41	Figure	figure	NN
cord-332422-s15o0hie	52	42	1	1	CD
cord-332422-s15o0hie	52	43	)	)	-RRB-
cord-332422-s15o0hie	52	44	.	.	.
cord-332422-s15o0hie	53	1	This	this	DT
cord-332422-s15o0hie	53	2	model	model	NN
cord-332422-s15o0hie	53	3	revealed	reveal	VBD
cord-332422-s15o0hie	53	4	the	the	DT
cord-332422-s15o0hie	53	5	distribution	distribution	NN
cord-332422-s15o0hie	53	6	of	of	IN
cord-332422-s15o0hie	53	7	E2	E2	NNP
cord-332422-s15o0hie	53	8	amino	amino	NNS
cord-332422-s15o0hie	53	9	acids	acid	NNS
cord-332422-s15o0hie	53	10	among	among	IN
cord-332422-s15o0hie	53	11	three	three	CD
cord-332422-s15o0hie	53	12	different	different	JJ
cord-332422-s15o0hie	53	13	domains	domain	NNS
cord-332422-s15o0hie	53	14	(	(	-LRB-
cord-332422-s15o0hie	53	15	DI	DI	NNP
cord-332422-s15o0hie	53	16	,	,	,
cord-332422-s15o0hie	53	17	DII	DII	NNP
cord-332422-s15o0hie	53	18	and	and	CC
cord-332422-s15o0hie	53	19	DIII	DIII	NNP
cord-332422-s15o0hie	53	20	)	)	-RRB-
cord-332422-s15o0hie	53	21	.	.	.
cord-332422-s15o0hie	54	1	The	the	DT
cord-332422-s15o0hie	54	2	DI	DI	NNP
cord-332422-s15o0hie	54	3	domain	domain	NN
cord-332422-s15o0hie	54	4	consists	consist	VBZ
cord-332422-s15o0hie	54	5	of	of	IN
cord-332422-s15o0hie	54	6	eight	eight	CD
cord-332422-s15o0hie	54	7	b	b	NN
cord-332422-s15o0hie	54	8	-	-	HYPH
cord-332422-s15o0hie	54	9	strands	strand	NNS
cord-332422-s15o0hie	54	10	and	and	CC
cord-332422-s15o0hie	54	11	is	be	VBZ
cord-332422-s15o0hie	54	12	extended	extend	VBN
cord-332422-s15o0hie	54	13	on	on	IN
cord-332422-s15o0hie	54	14	the	the	DT
cord-332422-s15o0hie	54	15	N	n	NN
cord-332422-s15o0hie	54	16	-	-	HYPH
cord-332422-s15o0hie	54	17	terminus	terminus	NN
cord-332422-s15o0hie	54	18	by	by	IN
cord-332422-s15o0hie	54	19	hypervariable	hypervariable	JJ
cord-332422-s15o0hie	54	20	region	region	NN
cord-332422-s15o0hie	54	21	1	1	CD
cord-332422-s15o0hie	54	22	(	(	-LRB-
cord-332422-s15o0hie	54	23	HVR1	HVR1	NNP
cord-332422-s15o0hie	54	24	)	)	-RRB-
cord-332422-s15o0hie	54	25	.	.	.
cord-332422-s15o0hie	55	1	This	this	DT
cord-332422-s15o0hie	55	2	domain	domain	NN
cord-332422-s15o0hie	55	3	,	,	,
cord-332422-s15o0hie	55	4	which	which	WDT
cord-332422-s15o0hie	55	5	contains	contain	VBZ
cord-332422-s15o0hie	55	6	determinants	determinant	NNS
cord-332422-s15o0hie	55	7	for	for	IN
cord-332422-s15o0hie	55	8	CD81	CD81	NNP
cord-332422-s15o0hie	55	9	interaction	interaction	NN
cord-332422-s15o0hie	55	10	,	,	,
cord-332422-s15o0hie	55	11	has	have	VBZ
cord-332422-s15o0hie	55	12	recently	recently	RB
cord-332422-s15o0hie	55	13	been	be	VBN
cord-332422-s15o0hie	55	14	functionally	functionally	RB
cord-332422-s15o0hie	55	15	confirmed	confirm	VBN
cord-332422-s15o0hie	55	16	[	[	-LRB-
cord-332422-s15o0hie	55	17	10	10	CD
cord-332422-s15o0hie	55	18	]	]	-RRB-
cord-332422-s15o0hie	55	19	.	.	.
cord-332422-s15o0hie	56	1	The	the	DT
cord-332422-s15o0hie	56	2	DII	DII	NNP
cord-332422-s15o0hie	56	3	domain	domain	NN
cord-332422-s15o0hie	56	4	includes	include	VBZ
cord-332422-s15o0hie	56	5	hypervariable	hypervariable	JJ
cord-332422-s15o0hie	56	6	region	region	NN
cord-332422-s15o0hie	56	7	2	2	CD
cord-332422-s15o0hie	56	8	(	(	-LRB-
cord-332422-s15o0hie	56	9	HVR2	HVR2	NNP
cord-332422-s15o0hie	56	10	)	)	-RRB-
cord-332422-s15o0hie	56	11	and	and	CC
cord-332422-s15o0hie	56	12	its	-PRON-	PRP$
cord-332422-s15o0hie	56	13	most	most	RBS
cord-332422-s15o0hie	56	14	conserved	conserved	JJ
cord-332422-s15o0hie	56	15	part	part	NN
cord-332422-s15o0hie	56	16	is	be	VBZ
cord-332422-s15o0hie	56	17	suggested	suggest	VBN
cord-332422-s15o0hie	56	18	to	to	TO
cord-332422-s15o0hie	56	19	act	act	VB
cord-332422-s15o0hie	56	20	as	as	IN
cord-332422-s15o0hie	56	21	a	a	DT
cord-332422-s15o0hie	56	22	fusion	fusion	NN
cord-332422-s15o0hie	56	23	loop	loop	NN
cord-332422-s15o0hie	56	24	(	(	-LRB-
cord-332422-s15o0hie	56	25	a.a	a.a	NNP
cord-332422-s15o0hie	56	26	.	.	NNP
cord-332422-s15o0hie	56	27	502	502	CD
cord-332422-s15o0hie	56	28	-	-	SYM
cord-332422-s15o0hie	56	29	520	520	CD
cord-332422-s15o0hie	56	30	)	)	-RRB-
cord-332422-s15o0hie	56	31	that	that	WDT
cord-332422-s15o0hie	56	32	inserts	insert	VBZ
cord-332422-s15o0hie	56	33	into	into	IN
cord-332422-s15o0hie	56	34	the	the	DT
cord-332422-s15o0hie	56	35	target	target	NN
cord-332422-s15o0hie	56	36	membrane	membrane	NN
cord-332422-s15o0hie	56	37	during	during	IN
cord-332422-s15o0hie	56	38	the	the	DT
cord-332422-s15o0hie	56	39	first	first	JJ
cord-332422-s15o0hie	56	40	step	step	NN
cord-332422-s15o0hie	56	41	of	of	IN
cord-332422-s15o0hie	56	42	membrane	membrane	NN
cord-332422-s15o0hie	56	43	fusion	fusion	NN
cord-332422-s15o0hie	56	44	.	.	.
cord-332422-s15o0hie	57	1	DI	DI	NNP
cord-332422-s15o0hie	57	2	is	be	VBZ
cord-332422-s15o0hie	57	3	connected	connect	VBN
cord-332422-s15o0hie	57	4	to	to	IN
cord-332422-s15o0hie	57	5	the	the	DT
cord-332422-s15o0hie	57	6	DIII	DIII	NNP
cord-332422-s15o0hie	57	7	domain	domain	NN
cord-332422-s15o0hie	57	8	by	by	IN
cord-332422-s15o0hie	57	9	a	a	DT
cord-332422-s15o0hie	57	10	linker	linker	NN
cord-332422-s15o0hie	57	11	region	region	NN
cord-332422-s15o0hie	57	12	called	call	VBN
cord-332422-s15o0hie	57	13	inter	inter	JJ
cord-332422-s15o0hie	57	14	-	-	JJ
cord-332422-s15o0hie	57	15	genotypic	genotypic	JJ
cord-332422-s15o0hie	57	16	variable	variable	JJ
cord-332422-s15o0hie	57	17	region	region	NN
cord-332422-s15o0hie	57	18	(	(	-LRB-
cord-332422-s15o0hie	57	19	IgVR	IgVR	NNP
cord-332422-s15o0hie	57	20	)	)	-RRB-
cord-332422-s15o0hie	57	21	.	.	.
cord-332422-s15o0hie	58	1	Finally	finally	RB
cord-332422-s15o0hie	58	2	,	,	,
cord-332422-s15o0hie	58	3	DIII	DIII	NNP
cord-332422-s15o0hie	58	4	is	be	VBZ
cord-332422-s15o0hie	58	5	connected	connect	VBN
cord-332422-s15o0hie	58	6	to	to	IN
cord-332422-s15o0hie	58	7	the	the	DT
cord-332422-s15o0hie	58	8	transmembrane	transmembrane	NN
cord-332422-s15o0hie	58	9	domain	domain	NN
cord-332422-s15o0hie	58	10	by	by	IN
cord-332422-s15o0hie	58	11	the	the	DT
cord-332422-s15o0hie	58	12	flexible	flexible	JJ
cord-332422-s15o0hie	58	13	stem	stem	NN
cord-332422-s15o0hie	58	14	region	region	NN
cord-332422-s15o0hie	58	15	.	.	.
cord-332422-s15o0hie	59	1	This	this	DT
cord-332422-s15o0hie	59	2	latter	latter	JJ
cord-332422-s15o0hie	59	3	region	region	NN
cord-332422-s15o0hie	59	4	is	be	VBZ
cord-332422-s15o0hie	59	5	potentially	potentially	RB
cord-332422-s15o0hie	59	6	involved	involve	VBN
cord-332422-s15o0hie	59	7	in	in	IN
cord-332422-s15o0hie	59	8	envelope	envelope	NN
cord-332422-s15o0hie	59	9	protein	protein	NN
cord-332422-s15o0hie	59	10	heterodimerization	heterodimerization	NN
cord-332422-s15o0hie	59	11	as	as	RB
cord-332422-s15o0hie	59	12	well	well	RB
cord-332422-s15o0hie	59	13	as	as	IN
cord-332422-s15o0hie	59	14	in	in	IN
cord-332422-s15o0hie	59	15	virus	virus	NN
cord-332422-s15o0hie	59	16	entry	entry	NN
cord-332422-s15o0hie	59	17	[	[	-LRB-
cord-332422-s15o0hie	59	18	10	10	CD
cord-332422-s15o0hie	59	19	,	,	,
cord-332422-s15o0hie	59	20	12	12	CD
cord-332422-s15o0hie	59	21	]	]	-RRB-
cord-332422-s15o0hie	59	22	.	.	.
cord-332422-s15o0hie	60	1	An	an	DT
cord-332422-s15o0hie	60	2	amphipathic	amphipathic	JJ
cord-332422-s15o0hie	60	3	helix	helix	NN
cord-332422-s15o0hie	60	4	,	,	,
cord-332422-s15o0hie	60	5	which	which	WDT
cord-332422-s15o0hie	60	6	likely	likely	RB
cord-332422-s15o0hie	60	7	folds	fold	VBZ
cord-332422-s15o0hie	60	8	upon	upon	IN
cord-332422-s15o0hie	60	9	membrane	membrane	NN
cord-332422-s15o0hie	60	10	binding	binding	NN
cord-332422-s15o0hie	60	11	has	have	VBZ
cord-332422-s15o0hie	60	12	been	be	VBN
cord-332422-s15o0hie	60	13	identified	identify	VBN
cord-332422-s15o0hie	60	14	in	in	IN
cord-332422-s15o0hie	60	15	the	the	DT
cord-332422-s15o0hie	60	16	C	C	NNP
cord-332422-s15o0hie	60	17	-	-	HYPH
cord-332422-s15o0hie	60	18	terminal	terminal	NN
cord-332422-s15o0hie	60	19	part	part	NN
cord-332422-s15o0hie	60	20	of	of	IN
cord-332422-s15o0hie	60	21	the	the	DT
cord-332422-s15o0hie	60	22	stem	stem	NN
cord-332422-s15o0hie	60	23	region	region	NN
cord-332422-s15o0hie	60	24	and	and	CC
cord-332422-s15o0hie	60	25	it	-PRON-	PRP
cord-332422-s15o0hie	60	26	has	have	VBZ
cord-332422-s15o0hie	60	27	been	be	VBN
cord-332422-s15o0hie	60	28	proposed	propose	VBN
cord-332422-s15o0hie	60	29	that	that	IN
cord-332422-s15o0hie	60	30	this	this	DT
cord-332422-s15o0hie	60	31	region	region	NN
cord-332422-s15o0hie	60	32	might	may	MD
cord-332422-s15o0hie	60	33	be	be	VB
cord-332422-s15o0hie	60	34	involved	involve	VBN
cord-332422-s15o0hie	60	35	in	in	IN
cord-332422-s15o0hie	60	36	the	the	DT
cord-332422-s15o0hie	60	37	reorganization	reorganization	NN
cord-332422-s15o0hie	60	38	of	of	IN
cord-332422-s15o0hie	60	39	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	60	40	complexes	complex	NNS
cord-332422-s15o0hie	60	41	taking	take	VBG
cord-332422-s15o0hie	60	42	place	place	NN
cord-332422-s15o0hie	60	43	during	during	IN
cord-332422-s15o0hie	60	44	the	the	DT
cord-332422-s15o0hie	60	45	fusion	fusion	NN
cord-332422-s15o0hie	60	46	process	process	NN
cord-332422-s15o0hie	60	47	[	[	-LRB-
cord-332422-s15o0hie	60	48	10	10	CD
cord-332422-s15o0hie	60	49	]	]	-RRB-
cord-332422-s15o0hie	60	50	.	.	.
cord-332422-s15o0hie	61	1	Among	among	IN
cord-332422-s15o0hie	61	2	the	the	DT
cord-332422-s15o0hie	61	3	most	most	RBS
cord-332422-s15o0hie	61	4	variable	variable	JJ
cord-332422-s15o0hie	61	5	regions	region	NNS
cord-332422-s15o0hie	61	6	,	,	,
cord-332422-s15o0hie	61	7	HVR1	HVR1	NNP
cord-332422-s15o0hie	61	8	has	have	VBZ
cord-332422-s15o0hie	61	9	been	be	VBN
cord-332422-s15o0hie	61	10	shown	show	VBN
cord-332422-s15o0hie	61	11	to	to	TO
cord-332422-s15o0hie	61	12	be	be	VB
cord-332422-s15o0hie	61	13	essential	essential	JJ
cord-332422-s15o0hie	61	14	for	for	IN
cord-332422-s15o0hie	61	15	the	the	DT
cord-332422-s15o0hie	61	16	interaction	interaction	NN
cord-332422-s15o0hie	61	17	of	of	IN
cord-332422-s15o0hie	61	18	HCV	HCV	NNP
cord-332422-s15o0hie	61	19	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	61	20	E2	E2	NNP
cord-332422-s15o0hie	61	21	with	with	IN
cord-332422-s15o0hie	61	22	the	the	DT
cord-332422-s15o0hie	61	23	known	know	VBN
cord-332422-s15o0hie	61	24	HCV	HCV	NNP
cord-332422-s15o0hie	61	25	receptor	receptor	NN
cord-332422-s15o0hie	61	26	SRB1	SRB1	NNP
cord-332422-s15o0hie	61	27	[	[	-LRB-
cord-332422-s15o0hie	61	28	13	13	CD
cord-332422-s15o0hie	61	29	]	]	-RRB-
cord-332422-s15o0hie	61	30	.	.	.
cord-332422-s15o0hie	62	1	Although	although	IN
cord-332422-s15o0hie	62	2	they	-PRON-	PRP
cord-332422-s15o0hie	62	3	have	have	VBP
cord-332422-s15o0hie	62	4	an	an	DT
cord-332422-s15o0hie	62	5	attenuated	attenuated	JJ
cord-332422-s15o0hie	62	6	phenotype	phenotype	NN
cord-332422-s15o0hie	62	7	,	,	,
cord-332422-s15o0hie	62	8	most	most	JJS
cord-332422-s15o0hie	62	9	viruses	virus	NNS
cord-332422-s15o0hie	62	10	lacking	lack	VBG
cord-332422-s15o0hie	62	11	HVR1	HVR1	NNP
cord-332422-s15o0hie	62	12	remain	remain	VBP
cord-332422-s15o0hie	62	13	infectious	infectious	JJ
cord-332422-s15o0hie	62	14	[	[	-LRB-
cord-332422-s15o0hie	62	15	14	14	CD
cord-332422-s15o0hie	62	16	]	]	-RRB-
cord-332422-s15o0hie	62	17	.	.	.
cord-332422-s15o0hie	63	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	63	2	,	,	,
cord-332422-s15o0hie	63	3	it	-PRON-	PRP
cord-332422-s15o0hie	63	4	has	have	VBZ
cord-332422-s15o0hie	63	5	been	be	VBN
cord-332422-s15o0hie	63	6	proposed	propose	VBN
cord-332422-s15o0hie	63	7	that	that	IN
cord-332422-s15o0hie	63	8	this	this	DT
cord-332422-s15o0hie	63	9	region	region	NN
cord-332422-s15o0hie	63	10	obstructs	obstruct	VBZ
cord-332422-s15o0hie	63	11	the	the	DT
cord-332422-s15o0hie	63	12	viral	viral	JJ
cord-332422-s15o0hie	63	13	CD81	CD81	NNP
cord-332422-s15o0hie	63	14	binding	bind	VBG
cord-332422-s15o0hie	63	15	site	site	NN
cord-332422-s15o0hie	63	16	as	as	RB
cord-332422-s15o0hie	63	17	well	well	RB
cord-332422-s15o0hie	63	18	as	as	IN
cord-332422-s15o0hie	63	19	conserved	conserve	VBN
cord-332422-s15o0hie	63	20	neutralizing	neutralize	VBG
cord-332422-s15o0hie	63	21	epitopes	epitope	NNS
cord-332422-s15o0hie	63	22	[	[	-LRB-
cord-332422-s15o0hie	63	23	14	14	CD
cord-332422-s15o0hie	63	24	,	,	,
cord-332422-s15o0hie	63	25	15	15	CD
cord-332422-s15o0hie	63	26	]	]	-RRB-
cord-332422-s15o0hie	63	27	,	,	,
cord-332422-s15o0hie	63	28	potentially	potentially	RB
cord-332422-s15o0hie	63	29	playing	play	VBG
cord-332422-s15o0hie	63	30	a	a	DT
cord-332422-s15o0hie	63	31	role	role	NN
cord-332422-s15o0hie	63	32	in	in	IN
cord-332422-s15o0hie	63	33	some	some	DT
cord-332422-s15o0hie	63	34	aspects	aspect	NNS
cord-332422-s15o0hie	63	35	of	of	IN
cord-332422-s15o0hie	63	36	HCV	HCV	NNP
cord-332422-s15o0hie	63	37	immune	immune	JJ
cord-332422-s15o0hie	63	38	evasion	evasion	NN
cord-332422-s15o0hie	63	39	.	.	.
cord-332422-s15o0hie	64	1	Surprisingly	surprisingly	RB
cord-332422-s15o0hie	64	2	,	,	,
cord-332422-s15o0hie	64	3	other	other	JJ
cord-332422-s15o0hie	64	4	non	non	JJ
cord-332422-s15o0hie	64	5	-	-	JJ
cord-332422-s15o0hie	64	6	conserved	conserved	JJ
cord-332422-s15o0hie	64	7	regions	region	NNS
cord-332422-s15o0hie	64	8	like	like	IN
cord-332422-s15o0hie	64	9	HVR2	HVR2	NNP
cord-332422-s15o0hie	64	10	and	and	CC
cord-332422-s15o0hie	64	11	IgVR	IgVR	NNP
cord-332422-s15o0hie	64	12	are	be	VBP
cord-332422-s15o0hie	64	13	essential	essential	JJ
cord-332422-s15o0hie	64	14	for	for	IN
cord-332422-s15o0hie	64	15	the	the	DT
cord-332422-s15o0hie	64	16	assembly	assembly	NN
cord-332422-s15o0hie	64	17	of	of	IN
cord-332422-s15o0hie	64	18	functional	functional	JJ
cord-332422-s15o0hie	64	19	E1E2	E1E2	NNP
cord-332422-s15o0hie	64	20	heterodimers	heterodimer	NNS
cord-332422-s15o0hie	64	21	[	[	-LRB-
cord-332422-s15o0hie	64	22	10	10	CD
cord-332422-s15o0hie	64	23	,	,	,
cord-332422-s15o0hie	64	24	16	16	CD
cord-332422-s15o0hie	64	25	,	,	,
cord-332422-s15o0hie	64	26	17	17	CD
cord-332422-s15o0hie	64	27	]	]	-RRB-
cord-332422-s15o0hie	64	28	.	.	.
cord-332422-s15o0hie	65	1	HCV	HCV	NNP
cord-332422-s15o0hie	65	2	envelope	envelope	NN
cord-332422-s15o0hie	65	3	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	65	4	,	,	,
cord-332422-s15o0hie	65	5	E1	E1	NNP
cord-332422-s15o0hie	65	6	and	and	CC
cord-332422-s15o0hie	65	7	E2	E2	NNP
cord-332422-s15o0hie	65	8	,	,	,
cord-332422-s15o0hie	65	9	contain	contain	VBP
cord-332422-s15o0hie	65	10	up	up	IN
cord-332422-s15o0hie	65	11	to	to	TO
cord-332422-s15o0hie	65	12	5	5	CD
cord-332422-s15o0hie	65	13	and	and	CC
cord-332422-s15o0hie	65	14	11	11	CD
cord-332422-s15o0hie	65	15	N	n	CD
cord-332422-s15o0hie	65	16	-	-	HYPH
cord-332422-s15o0hie	65	17	glycosylation	glycosylation	NN
cord-332422-s15o0hie	65	18	sites	site	NNS
cord-332422-s15o0hie	65	19	,	,	,
cord-332422-s15o0hie	65	20	respectively	respectively	RB
cord-332422-s15o0hie	65	21	.	.	.
cord-332422-s15o0hie	66	1	Most	Most	JJS
cord-332422-s15o0hie	66	2	HCV	HCV	NNP
cord-332422-s15o0hie	66	3	glycans	glycan	NNS
cord-332422-s15o0hie	66	4	are	be	VBP
cord-332422-s15o0hie	66	5	highly	highly	RB
cord-332422-s15o0hie	66	6	conserved	conserve	VBN
cord-332422-s15o0hie	66	7	[	[	-LRB-
cord-332422-s15o0hie	66	8	16	16	CD
cord-332422-s15o0hie	66	9	]	]	-RRB-
cord-332422-s15o0hie	66	10	and	and	CC
cord-332422-s15o0hie	66	11	some	some	DT
cord-332422-s15o0hie	66	12	have	have	VBP
cord-332422-s15o0hie	66	13	(	(	-LRB-
cord-332422-s15o0hie	66	14	TM	TM	NNP
cord-332422-s15o0hie	66	15	)	)	-RRB-
cord-332422-s15o0hie	66	16	are	be	VBP
cord-332422-s15o0hie	66	17	indicated	indicate	VBN
cord-332422-s15o0hie	66	18	at	at	IN
cord-332422-s15o0hie	66	19	the	the	DT
cord-332422-s15o0hie	66	20	C	C	NNP
cord-332422-s15o0hie	66	21	-	-	HYPH
cord-332422-s15o0hie	66	22	terminus	terminus	NN
cord-332422-s15o0hie	66	23	of	of	IN
cord-332422-s15o0hie	66	24	the	the	DT
cord-332422-s15o0hie	66	25	proteins	protein	NNS
cord-332422-s15o0hie	66	26	and	and	CC
cord-332422-s15o0hie	66	27	the	the	DT
cord-332422-s15o0hie	66	28	position	position	NN
cord-332422-s15o0hie	66	29	of	of	IN
cord-332422-s15o0hie	66	30	the	the	DT
cord-332422-s15o0hie	66	31	glycosylation	glycosylation	NN
cord-332422-s15o0hie	66	32	sites	site	NNS
cord-332422-s15o0hie	66	33	shown	show	VBN
cord-332422-s15o0hie	66	34	in	in	IN
cord-332422-s15o0hie	66	35	the	the	DT
cord-332422-s15o0hie	66	36	ectodomains	ectodomain	NNS
cord-332422-s15o0hie	66	37	.	.	.
cord-332422-s15o0hie	67	1	For	for	IN
cord-332422-s15o0hie	67	2	E2	E2	NNP
cord-332422-s15o0hie	67	3	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	67	4	,	,	,
cord-332422-s15o0hie	67	5	hypervariable	hypervariable	JJ
cord-332422-s15o0hie	67	6	region	region	NN
cord-332422-s15o0hie	67	7	1	1	CD
cord-332422-s15o0hie	67	8	(	(	-LRB-
cord-332422-s15o0hie	67	9	HVR1	HVR1	NNP
cord-332422-s15o0hie	67	10	)	)	-RRB-
cord-332422-s15o0hie	67	11	and	and	CC
cord-332422-s15o0hie	67	12	2	2	LS
cord-332422-s15o0hie	67	13	(	(	-LRB-
cord-332422-s15o0hie	67	14	HVR2	HVR2	NNP
cord-332422-s15o0hie	67	15	)	)	-RRB-
cord-332422-s15o0hie	67	16	and	and	CC
cord-332422-s15o0hie	67	17	intergenotypic	intergenotypic	JJ
cord-332422-s15o0hie	67	18	variable	variable	NN
cord-332422-s15o0hie	67	19	region	region	NN
cord-332422-s15o0hie	67	20	(	(	-LRB-
cord-332422-s15o0hie	67	21	IgVR	IgVR	NNP
cord-332422-s15o0hie	67	22	)	)	-RRB-
cord-332422-s15o0hie	67	23	are	be	VBP
cord-332422-s15o0hie	67	24	indicated	indicate	VBN
cord-332422-s15o0hie	67	25	.	.	.
cord-332422-s15o0hie	68	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	68	2	DI	DI	NNP
cord-332422-s15o0hie	68	3	,	,	,
cord-332422-s15o0hie	68	4	DII	DII	NNP
cord-332422-s15o0hie	68	5	and	and	CC
cord-332422-s15o0hie	68	6	DIII	DIII	NNP
cord-332422-s15o0hie	68	7	domains	domain	NNS
cord-332422-s15o0hie	68	8	and	and	CC
cord-332422-s15o0hie	68	9	the	the	DT
cord-332422-s15o0hie	68	10	stem	stem	NN
cord-332422-s15o0hie	68	11	regions	region	NNS
cord-332422-s15o0hie	68	12	are	be	VBP
cord-332422-s15o0hie	68	13	shown	show	VBN
cord-332422-s15o0hie	68	14	in	in	IN
cord-332422-s15o0hie	68	15	red	red	JJ
cord-332422-s15o0hie	68	16	,	,	,
cord-332422-s15o0hie	68	17	yellow	yellow	JJ
cord-332422-s15o0hie	68	18	,	,	,
cord-332422-s15o0hie	68	19	blue	blue	JJ
cord-332422-s15o0hie	68	20	and	and	CC
cord-332422-s15o0hie	68	21	grey	grey	JJ
cord-332422-s15o0hie	68	22	,	,	,
cord-332422-s15o0hie	68	23	respectively	respectively	RB
cord-332422-s15o0hie	68	24	.	.	.
cord-332422-s15o0hie	69	1	(	(	-LRB-
cord-332422-s15o0hie	69	2	B	b	NN
cord-332422-s15o0hie	69	3	)	)	-RRB-
cord-332422-s15o0hie	69	4	Model	Model	NNP
cord-332422-s15o0hie	69	5	of	of	IN
cord-332422-s15o0hie	69	6	E2	E2	NNP
cord-332422-s15o0hie	69	7	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	69	8	.	.	.
cord-332422-s15o0hie	70	1	The	the	DT
cord-332422-s15o0hie	70	2	linear	linear	JJ
cord-332422-s15o0hie	70	3	sequence	sequence	NN
cord-332422-s15o0hie	70	4	of	of	IN
cord-332422-s15o0hie	70	5	the	the	DT
cord-332422-s15o0hie	70	6	E2	E2	NNP
cord-332422-s15o0hie	70	7	ectodomain	ectodomain	NN
cord-332422-s15o0hie	70	8	(	(	-LRB-
cord-332422-s15o0hie	70	9	JFH1	JFH1	NNP
cord-332422-s15o0hie	70	10	strain	strain	NN
cord-332422-s15o0hie	70	11	;	;	:
cord-332422-s15o0hie	71	1	GenBank	genbank	VB
cord-332422-s15o0hie	71	2	access	access	NN
cord-332422-s15o0hie	71	3	number	number	NN
cord-332422-s15o0hie	71	4	AB237837	ab237837	NN
cord-332422-s15o0hie	71	5	)	)	-RRB-
cord-332422-s15o0hie	71	6	is	be	VBZ
cord-332422-s15o0hie	71	7	represented	represent	VBN
cord-332422-s15o0hie	71	8	as	as	IN
cord-332422-s15o0hie	71	9	a	a	DT
cord-332422-s15o0hie	71	10	chain	chain	NN
cord-332422-s15o0hie	71	11	of	of	IN
cord-332422-s15o0hie	71	12	beads	bead	NNS
cord-332422-s15o0hie	71	13	(	(	-LRB-
cord-332422-s15o0hie	71	14	colored	colored	JJ
cord-332422-s15o0hie	71	15	circles	circle	NNS
cord-332422-s15o0hie	71	16	)	)	-RRB-
cord-332422-s15o0hie	71	17	labeled	label	VBN
cord-332422-s15o0hie	71	18	with	with	IN
cord-332422-s15o0hie	71	19	the	the	DT
cord-332422-s15o0hie	71	20	corresponding	corresponding	JJ
cord-332422-s15o0hie	71	21	amino	amino	NN
cord-332422-s15o0hie	71	22	acid	acid	NN
cord-332422-s15o0hie	71	23	and	and	CC
cord-332422-s15o0hie	71	24	threaded	thread	VBN
cord-332422-s15o0hie	71	25	onto	onto	IN
cord-332422-s15o0hie	71	26	a	a	DT
cord-332422-s15o0hie	71	27	class	class	NN
cord-332422-s15o0hie	71	28	II	ii	NN
cord-332422-s15o0hie	71	29	fold	fold	NN
cord-332422-s15o0hie	71	30	,	,	,
cord-332422-s15o0hie	71	31	which	which	WDT
cord-332422-s15o0hie	71	32	is	be	VBZ
cord-332422-s15o0hie	71	33	an	an	DT
cord-332422-s15o0hie	71	34	adapted	adapt	VBN
cord-332422-s15o0hie	71	35	version	version	NN
cord-332422-s15o0hie	71	36	of	of	IN
cord-332422-s15o0hie	71	37	the	the	DT
cord-332422-s15o0hie	71	38	model	model	NN
cord-332422-s15o0hie	71	39	recently	recently	RB
cord-332422-s15o0hie	71	40	published	publish	VBN
cord-332422-s15o0hie	71	41	by	by	IN
cord-332422-s15o0hie	71	42	Krey	Krey	NNP
cord-332422-s15o0hie	71	43	et	et	NNP
cord-332422-s15o0hie	71	44	al	al	NNP
cord-332422-s15o0hie	71	45	.	.	.
cord-332422-s15o0hie	72	1	[	[	-LRB-
cord-332422-s15o0hie	72	2	11	11	CD
cord-332422-s15o0hie	72	3	]	]	-RRB-
cord-332422-s15o0hie	72	4	(	(	-LRB-
cord-332422-s15o0hie	72	5	doi	doi	FW
cord-332422-s15o0hie	72	6	:	:	:
cord-332422-s15o0hie	72	7	10.1371	10.1371	CD
cord-332422-s15o0hie	72	8	/	/	SYM
cord-332422-s15o0hie	72	9	journal.ppat.1000762.g006	journal.ppat.1000762.g006	NNP
cord-332422-s15o0hie	72	10	)	)	-RRB-
cord-332422-s15o0hie	72	11	.	.	.
cord-332422-s15o0hie	73	1	The	the	DT
cord-332422-s15o0hie	73	2	three	three	CD
cord-332422-s15o0hie	73	3	putative	putative	JJ
cord-332422-s15o0hie	73	4	domains	domain	NNS
cord-332422-s15o0hie	73	5	are	be	VBP
cord-332422-s15o0hie	73	6	presented	present	VBN
cord-332422-s15o0hie	73	7	in	in	IN
cord-332422-s15o0hie	73	8	red	red	JJ
cord-332422-s15o0hie	73	9	(	(	-LRB-
cord-332422-s15o0hie	73	10	DI	DI	NNP
cord-332422-s15o0hie	73	11	)	)	-RRB-
cord-332422-s15o0hie	73	12	,	,	,
cord-332422-s15o0hie	73	13	yellow	yellow	JJ
cord-332422-s15o0hie	73	14	(	(	-LRB-
cord-332422-s15o0hie	73	15	DII	DII	NNP
cord-332422-s15o0hie	73	16	)	)	-RRB-
cord-332422-s15o0hie	73	17	and	and	CC
cord-332422-s15o0hie	73	18	blue	blue	JJ
cord-332422-s15o0hie	73	19	(	(	-LRB-
cord-332422-s15o0hie	73	20	DIII	DIII	NNP
cord-332422-s15o0hie	73	21	)	)	-RRB-
cord-332422-s15o0hie	73	22	,	,	,
cord-332422-s15o0hie	73	23	and	and	CC
cord-332422-s15o0hie	73	24	the	the	DT
cord-332422-s15o0hie	73	25	variable	variable	JJ
cord-332422-s15o0hie	73	26	regions	region	NNS
cord-332422-s15o0hie	73	27	(	(	-LRB-
cord-332422-s15o0hie	73	28	HVR1	HVR1	NNP
cord-332422-s15o0hie	73	29	,	,	,
cord-332422-s15o0hie	73	30	HVR2	HVR2	NNP
cord-332422-s15o0hie	73	31	and	and	CC
cord-332422-s15o0hie	73	32	IgVR	IgVR	NNPS
cord-332422-s15o0hie	73	33	)	)	-RRB-
cord-332422-s15o0hie	73	34	are	be	VBP
cord-332422-s15o0hie	73	35	indicated	indicate	VBN
cord-332422-s15o0hie	73	36	in	in	IN
cord-332422-s15o0hie	73	37	brown	brown	JJ
cord-332422-s15o0hie	73	38	,	,	,
cord-332422-s15o0hie	73	39	whereas	whereas	IN
cord-332422-s15o0hie	73	40	the	the	DT
cord-332422-s15o0hie	73	41	stem	stem	NN
cord-332422-s15o0hie	73	42	region	region	NN
cord-332422-s15o0hie	73	43	is	be	VBZ
cord-332422-s15o0hie	73	44	shown	show	VBN
cord-332422-s15o0hie	73	45	in	in	IN
cord-332422-s15o0hie	73	46	grey	grey	NN
cord-332422-s15o0hie	73	47	.	.	.
cord-332422-s15o0hie	74	1	Circles	circle	NNS
cord-332422-s15o0hie	74	2	in	in	IN
cord-332422-s15o0hie	74	3	pale	pale	JJ
cord-332422-s15o0hie	74	4	and	and	CC
cord-332422-s15o0hie	74	5	bright	bright	JJ
cord-332422-s15o0hie	74	6	colors	color	NNS
cord-332422-s15o0hie	74	7	represent	represent	VBP
cord-332422-s15o0hie	74	8	residues	residue	NNS
cord-332422-s15o0hie	74	9	in	in	IN
cord-332422-s15o0hie	74	10	the	the	DT
cord-332422-s15o0hie	74	11	background	background	NN
cord-332422-s15o0hie	74	12	and	and	CC
cord-332422-s15o0hie	74	13	foreground	foreground	NN
cord-332422-s15o0hie	74	14	of	of	IN
cord-332422-s15o0hie	74	15	the	the	DT
cord-332422-s15o0hie	74	16	domains	domain	NNS
cord-332422-s15o0hie	74	17	,	,	,
cord-332422-s15o0hie	74	18	respectively	respectively	RB
cord-332422-s15o0hie	74	19	labeled	label	VBN
cord-332422-s15o0hie	74	20	in	in	IN
cord-332422-s15o0hie	74	21	white	white	JJ
cord-332422-s15o0hie	74	22	and	and	CC
cord-332422-s15o0hie	74	23	black	black	JJ
cord-332422-s15o0hie	74	24	fonts	font	NNS
cord-332422-s15o0hie	74	25	.	.	.
cord-332422-s15o0hie	75	1	Disulfide	disulfide	JJ
cord-332422-s15o0hie	75	2	bonds	bond	NNS
cord-332422-s15o0hie	75	3	are	be	VBP
cord-332422-s15o0hie	75	4	indicated	indicate	VBN
cord-332422-s15o0hie	75	5	by	by	IN
cord-332422-s15o0hie	75	6	black	black	JJ
cord-332422-s15o0hie	75	7	bars	bar	NNS
cord-332422-s15o0hie	75	8	.	.	.
cord-332422-s15o0hie	76	1	Glycosylation	glycosylation	NN
cord-332422-s15o0hie	76	2	sites	site	NNS
cord-332422-s15o0hie	76	3	are	be	VBP
cord-332422-s15o0hie	76	4	shown	show	VBN
cord-332422-s15o0hie	76	5	by	by	IN
cord-332422-s15o0hie	76	6	green	green	JJ
cord-332422-s15o0hie	76	7	circles	circle	NNS
cord-332422-s15o0hie	76	8	numbered	number	VBN
cord-332422-s15o0hie	76	9	sequentially	sequentially	RB
cord-332422-s15o0hie	76	10	.	.	.
cord-332422-s15o0hie	77	1	DI	DI	NNP
cord-332422-s15o0hie	77	2	domain	domain	NN
cord-332422-s15o0hie	77	3	residues	residue	NNS
cord-332422-s15o0hie	77	4	that	that	WDT
cord-332422-s15o0hie	77	5	participate	participate	VBP
cord-332422-s15o0hie	77	6	in	in	IN
cord-332422-s15o0hie	77	7	CD81	CD81	NNP
cord-332422-s15o0hie	77	8	binding	bind	VBG
cord-332422-s15o0hie	77	9	are	be	VBP
cord-332422-s15o0hie	77	10	contoured	contour	VBN
cord-332422-s15o0hie	77	11	in	in	IN
cord-332422-s15o0hie	77	12	blue	blue	JJ
cord-332422-s15o0hie	77	13	.	.	.
cord-332422-s15o0hie	78	1	been	be	VBN
cord-332422-s15o0hie	78	2	shown	show	VBN
cord-332422-s15o0hie	78	3	to	to	TO
cord-332422-s15o0hie	78	4	play	play	VB
cord-332422-s15o0hie	78	5	a	a	DT
cord-332422-s15o0hie	78	6	role	role	NN
cord-332422-s15o0hie	78	7	in	in	IN
cord-332422-s15o0hie	78	8	virus	virus	NN
cord-332422-s15o0hie	78	9	assembly	assembly	NN
cord-332422-s15o0hie	78	10	or	or	CC
cord-332422-s15o0hie	78	11	entry	entry	NN
cord-332422-s15o0hie	78	12	[	[	-LRB-
cord-332422-s15o0hie	78	13	18	18	CD
cord-332422-s15o0hie	78	14	]	]	-RRB-
cord-332422-s15o0hie	78	15	.	.	.
cord-332422-s15o0hie	79	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	79	2	,	,	,
cord-332422-s15o0hie	79	3	they	-PRON-	PRP
cord-332422-s15o0hie	79	4	form	form	VBP
cord-332422-s15o0hie	79	5	a	a	DT
cord-332422-s15o0hie	79	6	glycan	glycan	NN
cord-332422-s15o0hie	79	7	shield	shield	NN
cord-332422-s15o0hie	79	8	which	which	WDT
cord-332422-s15o0hie	79	9	protects	protect	VBZ
cord-332422-s15o0hie	79	10	the	the	DT
cord-332422-s15o0hie	79	11	virus	virus	NN
cord-332422-s15o0hie	79	12	from	from	IN
cord-332422-s15o0hie	79	13	antibody	antibody	NN
cord-332422-s15o0hie	79	14	neutralization	neutralization	NN
cord-332422-s15o0hie	79	15	[	[	-LRB-
cord-332422-s15o0hie	79	16	18	18	CD
cord-332422-s15o0hie	79	17	]	]	-RRB-
cord-332422-s15o0hie	79	18	.	.	.
cord-332422-s15o0hie	80	1	HCV	HCV	NNP
cord-332422-s15o0hie	80	2	virions	virion	NNS
cord-332422-s15o0hie	80	3	isolated	isolate	VBN
cord-332422-s15o0hie	80	4	from	from	IN
cord-332422-s15o0hie	80	5	patients	patient	NNS
cord-332422-s15o0hie	80	6	display	display	VBP
cord-332422-s15o0hie	80	7	a	a	DT
cord-332422-s15o0hie	80	8	broad	broad	JJ
cord-332422-s15o0hie	80	9	range	range	NN
cord-332422-s15o0hie	80	10	of	of	IN
cord-332422-s15o0hie	80	11	buoyant	buoyant	JJ
cord-332422-s15o0hie	80	12	densities	density	NNS
cord-332422-s15o0hie	80	13	and	and	CC
cord-332422-s15o0hie	80	14	are	be	VBP
cord-332422-s15o0hie	80	15	associated	associate	VBN
cord-332422-s15o0hie	80	16	with	with	IN
cord-332422-s15o0hie	80	17	host	host	NN
cord-332422-s15o0hie	80	18	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	80	19	and	and	CC
cord-332422-s15o0hie	80	20	antibodies	antibody	NNS
cord-332422-s15o0hie	80	21	.	.	.
cord-332422-s15o0hie	81	1	Virions	virion	NNS
cord-332422-s15o0hie	81	2	and	and	CC
cord-332422-s15o0hie	81	3	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	81	4	are	be	VBP
cord-332422-s15o0hie	81	5	believed	believe	VBN
cord-332422-s15o0hie	81	6	to	to	TO
cord-332422-s15o0hie	81	7	form	form	VB
cord-332422-s15o0hie	81	8	complexes	complex	NNS
cord-332422-s15o0hie	81	9	of	of	IN
cord-332422-s15o0hie	81	10	very	very	RB
cord-332422-s15o0hie	81	11	-	-	HYPH
cord-332422-s15o0hie	81	12	low	low	JJ
cord-332422-s15o0hie	81	13	to	to	IN
cord-332422-s15o0hie	81	14	low	low	JJ
cord-332422-s15o0hie	81	15	densities	density	NNS
cord-332422-s15o0hie	81	16	,	,	,
cord-332422-s15o0hie	81	17	called	call	VBN
cord-332422-s15o0hie	81	18	lipoviroparticles	lipoviroparticles	NNP
cord-332422-s15o0hie	81	19	[	[	-LRB-
cord-332422-s15o0hie	81	20	19	19	CD
cord-332422-s15o0hie	81	21	]	]	-RRB-
cord-332422-s15o0hie	81	22	.	.	.
cord-332422-s15o0hie	82	1	The	the	DT
cord-332422-s15o0hie	82	2	exact	exact	JJ
cord-332422-s15o0hie	82	3	nature	nature	NN
cord-332422-s15o0hie	82	4	of	of	IN
cord-332422-s15o0hie	82	5	HCV	HCV	NNP
cord-332422-s15o0hie	82	6	association	association	NN
cord-332422-s15o0hie	82	7	with	with	IN
cord-332422-s15o0hie	82	8	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	82	9	remains	remain	VBZ
cord-332422-s15o0hie	82	10	elusive	elusive	JJ
cord-332422-s15o0hie	82	11	,	,	,
cord-332422-s15o0hie	82	12	yet	yet	CC
cord-332422-s15o0hie	82	13	it	-PRON-	PRP
cord-332422-s15o0hie	82	14	has	have	VBZ
cord-332422-s15o0hie	82	15	been	be	VBN
cord-332422-s15o0hie	82	16	clearly	clearly	RB
cord-332422-s15o0hie	82	17	demonstrated	demonstrate	VBN
cord-332422-s15o0hie	82	18	that	that	IN
cord-332422-s15o0hie	82	19	infectivity	infectivity	NN
cord-332422-s15o0hie	82	20	is	be	VBZ
cord-332422-s15o0hie	82	21	correlated	correlate	VBN
cord-332422-s15o0hie	82	22	with	with	IN
cord-332422-s15o0hie	82	23	virus	virus	NN
cord-332422-s15o0hie	82	24	density	density	NN
cord-332422-s15o0hie	82	25	with	with	IN
cord-332422-s15o0hie	82	26	the	the	DT
cord-332422-s15o0hie	82	27	highest	high	JJS
cord-332422-s15o0hie	82	28	infectivity	infectivity	NN
cord-332422-s15o0hie	82	29	being	be	VBG
cord-332422-s15o0hie	82	30	found	find	VBN
cord-332422-s15o0hie	82	31	in	in	IN
cord-332422-s15o0hie	82	32	the	the	DT
cord-332422-s15o0hie	82	33	lowest	low	JJS
cord-332422-s15o0hie	82	34	density	density	NN
cord-332422-s15o0hie	82	35	fractions	fraction	NNS
cord-332422-s15o0hie	82	36	.	.	.
cord-332422-s15o0hie	83	1	A	a	DT
cord-332422-s15o0hie	83	2	recent	recent	JJ
cord-332422-s15o0hie	83	3	characterization	characterization	NN
cord-332422-s15o0hie	83	4	of	of	IN
cord-332422-s15o0hie	83	5	cell	cell	NN
cord-332422-s15o0hie	83	6	culture	culture	NN
cord-332422-s15o0hie	83	7	-	-	HYPH
cord-332422-s15o0hie	83	8	produced	produce	VBN
cord-332422-s15o0hie	83	9	particles	particle	NNS
cord-332422-s15o0hie	83	10	indicates	indicate	VBZ
cord-332422-s15o0hie	83	11	that	that	IN
cord-332422-s15o0hie	83	12	their	-PRON-	PRP$
cord-332422-s15o0hie	83	13	composition	composition	NN
cord-332422-s15o0hie	83	14	resembles	resemble	VBZ
cord-332422-s15o0hie	83	15	the	the	DT
cord-332422-s15o0hie	83	16	one	one	CD
cord-332422-s15o0hie	83	17	of	of	IN
cord-332422-s15o0hie	83	18	VLDL	VLDL	NNP
cord-332422-s15o0hie	83	19	and	and	CC
cord-332422-s15o0hie	83	20	LDL	LDL	NNP
cord-332422-s15o0hie	83	21	with	with	IN
cord-332422-s15o0hie	83	22	cholesteryl	cholesteryl	NNP
cord-332422-s15o0hie	83	23	esters	ester	NNS
cord-332422-s15o0hie	83	24	accounting	account	VBG
cord-332422-s15o0hie	83	25	for	for	IN
cord-332422-s15o0hie	83	26	almost	almost	RB
cord-332422-s15o0hie	83	27	half	half	NN
cord-332422-s15o0hie	83	28	of	of	IN
cord-332422-s15o0hie	83	29	the	the	DT
cord-332422-s15o0hie	83	30	total	total	JJ
cord-332422-s15o0hie	83	31	HCV	HCV	NNP
cord-332422-s15o0hie	83	32	lipids	lipid	NNS
cord-332422-s15o0hie	83	33	.	.	.
cord-332422-s15o0hie	84	1	Thus	thus	RB
cord-332422-s15o0hie	84	2	,	,	,
cord-332422-s15o0hie	84	3	HCV	HCV	NNP
cord-332422-s15o0hie	84	4	particles	particle	NNS
cord-332422-s15o0hie	84	5	possess	possess	VBP
cord-332422-s15o0hie	84	6	a	a	DT
cord-332422-s15o0hie	84	7	unique	unique	JJ
cord-332422-s15o0hie	84	8	lipid	lipid	NN
cord-332422-s15o0hie	84	9	composition	composition	NN
cord-332422-s15o0hie	84	10	that	that	WDT
cord-332422-s15o0hie	84	11	is	be	VBZ
cord-332422-s15o0hie	84	12	very	very	RB
cord-332422-s15o0hie	84	13	distinct	distinct	JJ
cord-332422-s15o0hie	84	14	from	from	IN
cord-332422-s15o0hie	84	15	all	all	DT
cord-332422-s15o0hie	84	16	other	other	JJ
cord-332422-s15o0hie	84	17	viruses	virus	NNS
cord-332422-s15o0hie	84	18	analyzed	analyze	VBN
cord-332422-s15o0hie	84	19	so	so	RB
cord-332422-s15o0hie	84	20	far	far	RB
cord-332422-s15o0hie	84	21	[	[	-LRB-
cord-332422-s15o0hie	84	22	20	20	CD
cord-332422-s15o0hie	84	23	]	]	-RRB-
cord-332422-s15o0hie	84	24	.	.	.
cord-332422-s15o0hie	85	1	Importantly	importantly	RB
cord-332422-s15o0hie	85	2	,	,	,
cord-332422-s15o0hie	85	3	changes	change	NNS
cord-332422-s15o0hie	85	4	in	in	IN
cord-332422-s15o0hie	85	5	the	the	DT
cord-332422-s15o0hie	85	6	nature	nature	NN
cord-332422-s15o0hie	85	7	of	of	IN
cord-332422-s15o0hie	85	8	HCV	HCV	NNP
cord-332422-s15o0hie	85	9	-	-	HYPH
cord-332422-s15o0hie	85	10	associated	associate	VBN
cord-332422-s15o0hie	85	11	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	85	12	by	by	IN
cord-332422-s15o0hie	85	13	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	85	14	lipase	lipase	NN
cord-332422-s15o0hie	85	15	affect	affect	VBP
cord-332422-s15o0hie	85	16	HCV	HCV	NNP
cord-332422-s15o0hie	85	17	infectivity	infectivity	NN
cord-332422-s15o0hie	85	18	,	,	,
cord-332422-s15o0hie	85	19	suggesting	suggest	VBG
cord-332422-s15o0hie	85	20	that	that	IN
cord-332422-s15o0hie	85	21	association	association	NN
cord-332422-s15o0hie	85	22	of	of	IN
cord-332422-s15o0hie	85	23	HCV	HCV	NNP
cord-332422-s15o0hie	85	24	with	with	IN
cord-332422-s15o0hie	85	25	specific	specific	JJ
cord-332422-s15o0hie	85	26	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	85	27	is	be	VBZ
cord-332422-s15o0hie	85	28	important	important	JJ
cord-332422-s15o0hie	85	29	for	for	IN
cord-332422-s15o0hie	85	30	infectivity	infectivity	NN
cord-332422-s15o0hie	85	31	[	[	-LRB-
cord-332422-s15o0hie	85	32	21	21	CD
cord-332422-s15o0hie	85	33	,	,	,
cord-332422-s15o0hie	85	34	22	22	CD
cord-332422-s15o0hie	85	35	]	]	-RRB-
cord-332422-s15o0hie	85	36	.	.	.
cord-332422-s15o0hie	86	1	It	-PRON-	PRP
cord-332422-s15o0hie	86	2	has	have	VBZ
cord-332422-s15o0hie	86	3	also	also	RB
cord-332422-s15o0hie	86	4	been	be	VBN
cord-332422-s15o0hie	86	5	shown	show	VBN
cord-332422-s15o0hie	86	6	that	that	IN
cord-332422-s15o0hie	86	7	the	the	DT
cord-332422-s15o0hie	86	8	HCV	HCV	NNP
cord-332422-s15o0hie	86	9	assembly	assembly	NN
cord-332422-s15o0hie	86	10	pathway	pathway	NN
cord-332422-s15o0hie	86	11	depends	depend	VBZ
cord-332422-s15o0hie	86	12	on	on	IN
cord-332422-s15o0hie	86	13	components	component	NNS
cord-332422-s15o0hie	86	14	of	of	IN
cord-332422-s15o0hie	86	15	the	the	DT
cord-332422-s15o0hie	86	16	VLDL	VLDL	NNP
cord-332422-s15o0hie	86	17	synthesis	synthesis	NN
cord-332422-s15o0hie	86	18	pathway	pathway	NN
cord-332422-s15o0hie	86	19	.	.	.
cord-332422-s15o0hie	87	1	The	the	DT
cord-332422-s15o0hie	87	2	contribution	contribution	NN
cord-332422-s15o0hie	87	3	of	of	IN
cord-332422-s15o0hie	87	4	different	different	JJ
cord-332422-s15o0hie	87	5	VLDL	VLDL	NNP
cord-332422-s15o0hie	87	6	pathway	pathway	NN
cord-332422-s15o0hie	87	7	components	component	NNS
cord-332422-s15o0hie	87	8	is	be	VBZ
cord-332422-s15o0hie	87	9	still	still	RB
cord-332422-s15o0hie	87	10	under	under	IN
cord-332422-s15o0hie	87	11	debate	debate	NN
cord-332422-s15o0hie	87	12	.	.	.
cord-332422-s15o0hie	88	1	Some	some	DT
cord-332422-s15o0hie	88	2	groups	group	NNS
cord-332422-s15o0hie	88	3	have	have	VBP
cord-332422-s15o0hie	88	4	found	find	VBN
cord-332422-s15o0hie	88	5	apoB	apoB	NNS
cord-332422-s15o0hie	88	6	and	and	CC
cord-332422-s15o0hie	88	7	microsomal	microsomal	NNP
cord-332422-s15o0hie	88	8	triglyceride	triglyceride	NN
cord-332422-s15o0hie	88	9	transfer	transfer	NN
cord-332422-s15o0hie	88	10	protein	protein	NN
cord-332422-s15o0hie	88	11	as	as	IN
cord-332422-s15o0hie	88	12	major	major	JJ
cord-332422-s15o0hie	88	13	contributors	contributor	NNS
cord-332422-s15o0hie	88	14	while	while	IN
cord-332422-s15o0hie	88	15	others	other	NNS
cord-332422-s15o0hie	88	16	indicate	indicate	VBP
cord-332422-s15o0hie	88	17	that	that	IN
cord-332422-s15o0hie	88	18	apoE	apoe	PRP
cord-332422-s15o0hie	88	19	plays	play	VBZ
cord-332422-s15o0hie	88	20	a	a	DT
cord-332422-s15o0hie	88	21	more	more	RBR
cord-332422-s15o0hie	88	22	predominant	predominant	JJ
cord-332422-s15o0hie	88	23	role	role	NN
cord-332422-s15o0hie	88	24	.	.	.
cord-332422-s15o0hie	89	1	Some	some	DT
cord-332422-s15o0hie	89	2	explanations	explanation	NNS
cord-332422-s15o0hie	89	3	and	and	CC
cord-332422-s15o0hie	89	4	models	model	NNS
cord-332422-s15o0hie	89	5	to	to	TO
cord-332422-s15o0hie	89	6	accommodate	accommodate	VB
cord-332422-s15o0hie	89	7	the	the	DT
cord-332422-s15o0hie	89	8	apparent	apparent	JJ
cord-332422-s15o0hie	89	9	conflicting	conflict	VBG
cord-332422-s15o0hie	89	10	data	datum	NNS
cord-332422-s15o0hie	89	11	have	have	VBP
cord-332422-s15o0hie	89	12	recently	recently	RB
cord-332422-s15o0hie	89	13	been	be	VBN
cord-332422-s15o0hie	89	14	proposed	propose	VBN
cord-332422-s15o0hie	89	15	[	[	-LRB-
cord-332422-s15o0hie	89	16	2	2	CD
cord-332422-s15o0hie	89	17	]	]	-RRB-
cord-332422-s15o0hie	89	18	.	.	.
cord-332422-s15o0hie	90	1	ApoE	ApoE	NNP
cord-332422-s15o0hie	90	2	is	be	VBZ
cord-332422-s15o0hie	90	3	a	a	DT
cord-332422-s15o0hie	90	4	ligand	ligand	NN
cord-332422-s15o0hie	90	5	for	for	IN
cord-332422-s15o0hie	90	6	two	two	CD
cord-332422-s15o0hie	90	7	molecules	molecule	NNS
cord-332422-s15o0hie	90	8	that	that	WDT
cord-332422-s15o0hie	90	9	are	be	VBP
cord-332422-s15o0hie	90	10	involved	involve	VBN
cord-332422-s15o0hie	90	11	in	in	IN
cord-332422-s15o0hie	90	12	HCV	HCV	NNP
cord-332422-s15o0hie	90	13	infection	infection	NN
cord-332422-s15o0hie	90	14	:	:	:
cord-332422-s15o0hie	90	15	the	the	DT
cord-332422-s15o0hie	90	16	low	low	JJ
cord-332422-s15o0hie	90	17	-	-	HYPH
cord-332422-s15o0hie	90	18	density	density	NN
cord-332422-s15o0hie	90	19	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	90	20	receptor	receptor	NN
cord-332422-s15o0hie	90	21	(	(	-LRB-
cord-332422-s15o0hie	90	22	LDLR	LDLR	NNP
cord-332422-s15o0hie	90	23	)	)	-RRB-
cord-332422-s15o0hie	90	24	and	and	CC
cord-332422-s15o0hie	90	25	SRB1	SRB1	NNP
cord-332422-s15o0hie	90	26	.	.	.
cord-332422-s15o0hie	91	1	Antibodies	antibody	NNS
cord-332422-s15o0hie	91	2	directed	direct	VBN
cord-332422-s15o0hie	91	3	against	against	IN
cord-332422-s15o0hie	91	4	apoE	apoE	NNS
cord-332422-s15o0hie	91	5	inhibit	inhibit	VB
cord-332422-s15o0hie	91	6	HCV	HCV	NNP
cord-332422-s15o0hie	91	7	infection	infection	NN
cord-332422-s15o0hie	91	8	[	[	-LRB-
cord-332422-s15o0hie	91	9	23	23	CD
cord-332422-s15o0hie	91	10	,	,	,
cord-332422-s15o0hie	91	11	24	24	CD
cord-332422-s15o0hie	91	12	]	]	-RRB-
cord-332422-s15o0hie	91	13	,	,	,
cord-332422-s15o0hie	91	14	thus	thus	RB
cord-332422-s15o0hie	91	15	supporting	support	VBG
cord-332422-s15o0hie	91	16	a	a	DT
cord-332422-s15o0hie	91	17	role	role	NN
cord-332422-s15o0hie	91	18	for	for	IN
cord-332422-s15o0hie	91	19	apoE	apoE	NNS
cord-332422-s15o0hie	91	20	in	in	IN
cord-332422-s15o0hie	91	21	HCV	HCV	NNP
cord-332422-s15o0hie	91	22	entry	entry	NN
cord-332422-s15o0hie	91	23	.	.	.
cord-332422-s15o0hie	92	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	92	2	,	,	,
cord-332422-s15o0hie	92	3	the	the	DT
cord-332422-s15o0hie	92	4	apoE	apoE	NNPS
cord-332422-s15o0hie	92	5	isoform	isoform	NN
cord-332422-s15o0hie	92	6	associated	associate	VBN
cord-332422-s15o0hie	92	7	with	with	IN
cord-332422-s15o0hie	92	8	HCV	HCV	NNP
cord-332422-s15o0hie	92	9	particles	particle	NNS
cord-332422-s15o0hie	92	10	has	have	VBZ
cord-332422-s15o0hie	92	11	been	be	VBN
cord-332422-s15o0hie	92	12	shown	show	VBN
cord-332422-s15o0hie	92	13	to	to	TO
cord-332422-s15o0hie	92	14	affect	affect	VB
cord-332422-s15o0hie	92	15	the	the	DT
cord-332422-s15o0hie	92	16	level	level	NN
cord-332422-s15o0hie	92	17	of	of	IN
cord-332422-s15o0hie	92	18	virus	virus	NN
cord-332422-s15o0hie	92	19	infectivity	infectivity	NN
cord-332422-s15o0hie	92	20	[	[	-LRB-
cord-332422-s15o0hie	92	21	24	24	CD
cord-332422-s15o0hie	92	22	]	]	-RRB-
cord-332422-s15o0hie	92	23	.	.	.
cord-332422-s15o0hie	93	1	The	the	DT
cord-332422-s15o0hie	93	2	apoE	apoE	NNS
cord-332422-s15o0hie	93	3	gene	gene	NN
cord-332422-s15o0hie	93	4	is	be	VBZ
cord-332422-s15o0hie	93	5	indeed	indeed	RB
cord-332422-s15o0hie	93	6	polymorphic	polymorphic	JJ
cord-332422-s15o0hie	93	7	with	with	IN
cord-332422-s15o0hie	93	8	different	different	JJ
cord-332422-s15o0hie	93	9	alleles	allele	NNS
cord-332422-s15o0hie	93	10	leading	lead	VBG
cord-332422-s15o0hie	93	11	to	to	IN
cord-332422-s15o0hie	93	12	the	the	DT
cord-332422-s15o0hie	93	13	production	production	NN
cord-332422-s15o0hie	93	14	of	of	IN
cord-332422-s15o0hie	93	15	3	3	CD
cord-332422-s15o0hie	93	16	different	different	JJ
cord-332422-s15o0hie	93	17	isoforms	isoform	NNS
cord-332422-s15o0hie	93	18	,	,	,
cord-332422-s15o0hie	93	19	apoE2	apoe2	ADD
cord-332422-s15o0hie	93	20	,	,	,
cord-332422-s15o0hie	93	21	apoE3	apoE3	.
cord-332422-s15o0hie	94	1	and	and	CC
cord-332422-s15o0hie	94	2	apoE4	apoe4	UH
cord-332422-s15o0hie	94	3	.	.	.
cord-332422-s15o0hie	95	1	These	these	DT
cord-332422-s15o0hie	95	2	isoforms	isoform	NNS
cord-332422-s15o0hie	95	3	show	show	VBP
cord-332422-s15o0hie	95	4	different	different	JJ
cord-332422-s15o0hie	95	5	affinities	affinity	NNS
cord-332422-s15o0hie	95	6	for	for	IN
cord-332422-s15o0hie	95	7	LDLR	LDLR	NNP
cord-332422-s15o0hie	95	8	,	,	,
cord-332422-s15o0hie	95	9	with	with	IN
cord-332422-s15o0hie	95	10	apoE2	apoe2	ADD
cord-332422-s15o0hie	95	11	having	have	VBG
cord-332422-s15o0hie	95	12	a	a	DT
cord-332422-s15o0hie	95	13	very	very	RB
cord-332422-s15o0hie	95	14	low	low	JJ
cord-332422-s15o0hie	95	15	affinity	affinity	NN
cord-332422-s15o0hie	95	16	for	for	IN
cord-332422-s15o0hie	95	17	this	this	DT
cord-332422-s15o0hie	95	18	receptor	receptor	NN
cord-332422-s15o0hie	95	19	.	.	.
cord-332422-s15o0hie	96	1	Infectivity	infectivity	NN
cord-332422-s15o0hie	96	2	of	of	IN
cord-332422-s15o0hie	96	3	virions	virion	NNS
cord-332422-s15o0hie	96	4	produced	produce	VBN
cord-332422-s15o0hie	96	5	in	in	IN
cord-332422-s15o0hie	96	6	apoE	apoe	PRP$
cord-332422-s15o0hie	96	7	knockdown	knockdown	NN
cord-332422-s15o0hie	96	8	cells	cell	NNS
cord-332422-s15o0hie	96	9	could	could	MD
cord-332422-s15o0hie	96	10	be	be	VB
cord-332422-s15o0hie	96	11	properly	properly	RB
cord-332422-s15o0hie	96	12	restored	restore	VBN
cord-332422-s15o0hie	96	13	by	by	IN
cord-332422-s15o0hie	96	14	apoE3	apoE3	,
cord-332422-s15o0hie	96	15	and	and	CC
cord-332422-s15o0hie	96	16	apoE4	apoe4	DT
cord-332422-s15o0hie	96	17	expression	expression	NN
cord-332422-s15o0hie	96	18	but	but	CC
cord-332422-s15o0hie	97	1	only	only	RB
cord-332422-s15o0hie	97	2	very	very	RB
cord-332422-s15o0hie	97	3	poorly	poorly	RB
cord-332422-s15o0hie	97	4	by	by	IN
cord-332422-s15o0hie	97	5	apoE2	apoe2	ADD
cord-332422-s15o0hie	97	6	[	[	-LRB-
cord-332422-s15o0hie	97	7	24	24	CD
cord-332422-s15o0hie	97	8	]	]	-RRB-
cord-332422-s15o0hie	97	9	.	.	.
cord-332422-s15o0hie	98	1	Among	among	IN
cord-332422-s15o0hie	98	2	other	other	JJ
cord-332422-s15o0hie	98	3	apolipoproteins	apolipoprotein	NNS
cord-332422-s15o0hie	98	4	,	,	,
cord-332422-s15o0hie	98	5	apoC1	apoC1	''
cord-332422-s15o0hie	98	6	is	be	VBZ
cord-332422-s15o0hie	98	7	another	another	DT
cord-332422-s15o0hie	98	8	factor	factor	NN
cord-332422-s15o0hie	98	9	that	that	WDT
cord-332422-s15o0hie	98	10	could	could	MD
cord-332422-s15o0hie	98	11	also	also	RB
cord-332422-s15o0hie	98	12	potentially	potentially	RB
cord-332422-s15o0hie	98	13	play	play	VB
cord-332422-s15o0hie	98	14	a	a	DT
cord-332422-s15o0hie	98	15	role	role	NN
cord-332422-s15o0hie	98	16	in	in	IN
cord-332422-s15o0hie	98	17	HCV	HCV	NNP
cord-332422-s15o0hie	98	18	entry	entry	NN
cord-332422-s15o0hie	98	19	[	[	-LRB-
cord-332422-s15o0hie	98	20	25	25	CD
cord-332422-s15o0hie	98	21	]	]	-RRB-
cord-332422-s15o0hie	98	22	.	.	.
cord-332422-s15o0hie	99	1	SRB1	SRB1	NNP
cord-332422-s15o0hie	99	2	is	be	VBZ
cord-332422-s15o0hie	99	3	a	a	DT
cord-332422-s15o0hie	99	4	major	major	JJ
cord-332422-s15o0hie	99	5	receptor	receptor	NN
cord-332422-s15o0hie	99	6	for	for	IN
cord-332422-s15o0hie	99	7	high	high	JJ
cord-332422-s15o0hie	99	8	-	-	HYPH
cord-332422-s15o0hie	99	9	density	density	NN
cord-332422-s15o0hie	99	10	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	99	11	(	(	-LRB-
cord-332422-s15o0hie	99	12	HDL	HDL	NNP
cord-332422-s15o0hie	99	13	)	)	-RRB-
cord-332422-s15o0hie	99	14	.	.	.
cord-332422-s15o0hie	100	1	In	in	IN
cord-332422-s15o0hie	100	2	addition	addition	NN
cord-332422-s15o0hie	100	3	,	,	,
cord-332422-s15o0hie	100	4	other	other	JJ
cord-332422-s15o0hie	100	5	ligands	ligand	NNS
cord-332422-s15o0hie	100	6	for	for	IN
cord-332422-s15o0hie	100	7	SRB1	SRB1	NNP
cord-332422-s15o0hie	100	8	have	have	VBP
cord-332422-s15o0hie	100	9	been	be	VBN
cord-332422-s15o0hie	100	10	reported	report	VBN
cord-332422-s15o0hie	100	11	to	to	TO
cord-332422-s15o0hie	100	12	include	include	VB
cord-332422-s15o0hie	100	13	native	native	JJ
cord-332422-s15o0hie	100	14	and	and	CC
cord-332422-s15o0hie	100	15	modified	modified	JJ
cord-332422-s15o0hie	100	16	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	100	17	and	and	CC
cord-332422-s15o0hie	100	18	modified	modify	VBN
cord-332422-s15o0hie	100	19	serum	serum	NN
cord-332422-s15o0hie	100	20	proteins	protein	NNS
cord-332422-s15o0hie	100	21	.	.	.
cord-332422-s15o0hie	101	1	This	this	DT
cord-332422-s15o0hie	101	2	receptor	receptor	NN
cord-332422-s15o0hie	101	3	plays	play	VBZ
cord-332422-s15o0hie	101	4	a	a	DT
cord-332422-s15o0hie	101	5	crucial	crucial	JJ
cord-332422-s15o0hie	101	6	role	role	NN
cord-332422-s15o0hie	101	7	in	in	IN
cord-332422-s15o0hie	101	8	selective	selective	JJ
cord-332422-s15o0hie	101	9	lipid	lipid	NN
cord-332422-s15o0hie	101	10	uptake	uptake	NN
cord-332422-s15o0hie	101	11	and	and	CC
cord-332422-s15o0hie	101	12	bidirectional	bidirectional	JJ
cord-332422-s15o0hie	101	13	transfer	transfer	NN
cord-332422-s15o0hie	101	14	of	of	IN
cord-332422-s15o0hie	101	15	free	free	JJ
cord-332422-s15o0hie	101	16	cholesterol	cholesterol	NN
cord-332422-s15o0hie	101	17	.	.	.
cord-332422-s15o0hie	102	1	SRB1	SRB1	NNP
cord-332422-s15o0hie	102	2	contains	contain	VBZ
cord-332422-s15o0hie	102	3	two	two	CD
cord-332422-s15o0hie	102	4	membrane	membrane	NN
cord-332422-s15o0hie	102	5	spanning	spanning	NN
cord-332422-s15o0hie	102	6	sequences	sequence	NNS
cord-332422-s15o0hie	102	7	flanking	flank	VBG
cord-332422-s15o0hie	102	8	a	a	DT
cord-332422-s15o0hie	102	9	large	large	JJ
cord-332422-s15o0hie	102	10	N	n	CD
cord-332422-s15o0hie	102	11	-	-	HYPH
cord-332422-s15o0hie	102	12	glycosylated	glycosylate	VBN
cord-332422-s15o0hie	102	13	extracellular	extracellular	JJ
cord-332422-s15o0hie	102	14	loop	loop	NN
cord-332422-s15o0hie	102	15	and	and	CC
cord-332422-s15o0hie	102	16	two	two	CD
cord-332422-s15o0hie	102	17	short	short	JJ
cord-332422-s15o0hie	102	18	intracellular	intracellular	JJ
cord-332422-s15o0hie	102	19	domains	domain	NNS
cord-332422-s15o0hie	102	20	(	(	-LRB-
cord-332422-s15o0hie	102	21	Figure	figure	NN
cord-332422-s15o0hie	102	22	2	2	CD
cord-332422-s15o0hie	102	23	)	)	-RRB-
cord-332422-s15o0hie	102	24	.	.	.
cord-332422-s15o0hie	103	1	The	the	DT
cord-332422-s15o0hie	103	2	role	role	NN
cord-332422-s15o0hie	103	3	of	of	IN
cord-332422-s15o0hie	103	4	SRB1	SRB1	NNP
cord-332422-s15o0hie	103	5	in	in	IN
cord-332422-s15o0hie	103	6	HCV	HCV	NNP
cord-332422-s15o0hie	103	7	entry	entry	NN
cord-332422-s15o0hie	103	8	was	be	VBD
cord-332422-s15o0hie	103	9	first	first	RB
cord-332422-s15o0hie	103	10	suggested	suggest	VBN
cord-332422-s15o0hie	103	11	by	by	IN
cord-332422-s15o0hie	103	12	its	-PRON-	PRP$
cord-332422-s15o0hie	103	13	ability	ability	NN
cord-332422-s15o0hie	103	14	to	to	TO
cord-332422-s15o0hie	103	15	mediate	mediate	VB
cord-332422-s15o0hie	103	16	soluble	soluble	JJ
cord-332422-s15o0hie	103	17	E2	e2	NN
cord-332422-s15o0hie	103	18	binding	bind	VBG
cord-332422-s15o0hie	103	19	[	[	-LRB-
cord-332422-s15o0hie	103	20	13	13	CD
cord-332422-s15o0hie	103	21	]	]	-RRB-
cord-332422-s15o0hie	103	22	and	and	CC
cord-332422-s15o0hie	103	23	it	-PRON-	PRP
cord-332422-s15o0hie	103	24	was	be	VBD
cord-332422-s15o0hie	103	25	later	later	RB
cord-332422-s15o0hie	103	26	confirmed	confirm	VBN
cord-332422-s15o0hie	103	27	by	by	IN
cord-332422-s15o0hie	103	28	the	the	DT
cord-332422-s15o0hie	103	29	inhibition	inhibition	NN
cord-332422-s15o0hie	103	30	of	of	IN
cord-332422-s15o0hie	103	31	HCV	HCV	NNP
cord-332422-s15o0hie	103	32	infection	infection	NN
cord-332422-s15o0hie	103	33	with	with	IN
cord-332422-s15o0hie	103	34	anti	anti	JJ
cord-332422-s15o0hie	103	35	-	-	JJ
cord-332422-s15o0hie	103	36	SRB1	srb1	JJ
cord-332422-s15o0hie	103	37	antibodies	antibody	NNS
cord-332422-s15o0hie	103	38	and	and	CC
cord-332422-s15o0hie	103	39	by	by	IN
cord-332422-s15o0hie	103	40	silencing	silence	VBG
cord-332422-s15o0hie	103	41	of	of	IN
cord-332422-s15o0hie	103	42	the	the	DT
cord-332422-s15o0hie	103	43	protein	protein	NN
cord-332422-s15o0hie	103	44	in	in	IN
cord-332422-s15o0hie	103	45	hepatoma	hepatoma	NNP
cord-332422-s15o0hie	103	46	cells	cell	NNS
cord-332422-s15o0hie	103	47	(	(	-LRB-
cord-332422-s15o0hie	103	48	reviewed	review	VBN
cord-332422-s15o0hie	103	49	in	in	IN
cord-332422-s15o0hie	103	50	[	[	-LRB-
cord-332422-s15o0hie	103	51	5	5	CD
cord-332422-s15o0hie	103	52	,	,	,
cord-332422-s15o0hie	103	53	26	26	CD
cord-332422-s15o0hie	103	54	,	,	,
cord-332422-s15o0hie	103	55	27	27	CD
cord-332422-s15o0hie	103	56	]	]	-RRB-
cord-332422-s15o0hie	103	57	)	)	-RRB-
cord-332422-s15o0hie	103	58	.	.	.
cord-332422-s15o0hie	104	1	SRB1	SRB1	NNP
cord-332422-s15o0hie	104	2	residues	residue	NNS
cord-332422-s15o0hie	104	3	potentially	potentially	RB
cord-332422-s15o0hie	104	4	involved	involve	VBN
cord-332422-s15o0hie	104	5	in	in	IN
cord-332422-s15o0hie	104	6	E2	E2	NNP
cord-332422-s15o0hie	104	7	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	104	8	binding	binding	NN
cord-332422-s15o0hie	104	9	have	have	VBP
cord-332422-s15o0hie	104	10	recently	recently	RB
cord-332422-s15o0hie	104	11	been	be	VBN
cord-332422-s15o0hie	104	12	identified	identify	VBN
cord-332422-s15o0hie	104	13	in	in	IN
cord-332422-s15o0hie	104	14	its	-PRON-	PRP$
cord-332422-s15o0hie	104	15	ectodomain	ectodomain	JJ
cord-332422-s15o0hie	104	16	[	[	-LRB-
cord-332422-s15o0hie	104	17	28	28	CD
cord-332422-s15o0hie	104	18	]	]	-RRB-
cord-332422-s15o0hie	104	19	.	.	.
cord-332422-s15o0hie	105	1	Indeed	indeed	RB
cord-332422-s15o0hie	105	2	,	,	,
cord-332422-s15o0hie	105	3	amino	amino	JJ
cord-332422-s15o0hie	105	4	acids	acid	NNS
cord-332422-s15o0hie	105	5	70	70	CD
cord-332422-s15o0hie	105	6	-	-	HYPH
cord-332422-s15o0hie	105	7	87	87	CD
cord-332422-s15o0hie	105	8	and	and	CC
cord-332422-s15o0hie	105	9	the	the	DT
cord-332422-s15o0hie	105	10	residue	residue	NN
cord-332422-s15o0hie	105	11	E210	E210	NNS
cord-332422-s15o0hie	105	12	are	be	VBP
cord-332422-s15o0hie	105	13	required	require	VBN
cord-332422-s15o0hie	105	14	for	for	IN
cord-332422-s15o0hie	105	15	E2	E2	NNP
cord-332422-s15o0hie	105	16	recognition	recognition	NN
cord-332422-s15o0hie	105	17	.	.	.
cord-332422-s15o0hie	106	1	Alternative	alternative	JJ
cord-332422-s15o0hie	106	2	splicing	splicing	NN
cord-332422-s15o0hie	106	3	of	of	IN
cord-332422-s15o0hie	106	4	the	the	DT
cord-332422-s15o0hie	106	5	transcript	transcript	NN
cord-332422-s15o0hie	106	6	leads	lead	VBZ
cord-332422-s15o0hie	106	7	to	to	IN
cord-332422-s15o0hie	106	8	the	the	DT
cord-332422-s15o0hie	106	9	production	production	NN
cord-332422-s15o0hie	106	10	of	of	IN
cord-332422-s15o0hie	106	11	SRB2	SRB2	NNP
cord-332422-s15o0hie	106	12	which	which	WDT
cord-332422-s15o0hie	106	13	differs	differ	VBZ
cord-332422-s15o0hie	106	14	from	from	IN
cord-332422-s15o0hie	106	15	SRB1	SRB1	NNP
cord-332422-s15o0hie	106	16	only	only	RB
cord-332422-s15o0hie	106	17	in	in	IN
cord-332422-s15o0hie	106	18	its	-PRON-	PRP$
cord-332422-s15o0hie	106	19	C	c	NN
cord-332422-s15o0hie	106	20	-	-	HYPH
cord-332422-s15o0hie	106	21	terminal	terminal	NN
cord-332422-s15o0hie	106	22	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	106	23	domain	domain	NN
cord-332422-s15o0hie	106	24	.	.	.
cord-332422-s15o0hie	107	1	The	the	DT
cord-332422-s15o0hie	107	2	SRB2	SRB2	NNP
cord-332422-s15o0hie	107	3	C	C	NNP
cord-332422-s15o0hie	107	4	-	-	HYPH
cord-332422-s15o0hie	107	5	terminal	terminal	NN
cord-332422-s15o0hie	107	6	domain	domain	NN
cord-332422-s15o0hie	107	7	is	be	VBZ
cord-332422-s15o0hie	107	8	reported	report	VBN
cord-332422-s15o0hie	107	9	to	to	TO
cord-332422-s15o0hie	107	10	mediate	mediate	VB
cord-332422-s15o0hie	107	11	rapid	rapid	JJ
cord-332422-s15o0hie	107	12	internalization	internalization	NN
cord-332422-s15o0hie	107	13	and	and	CC
cord-332422-s15o0hie	107	14	intracellular	intracellular	JJ
cord-332422-s15o0hie	107	15	localization	localization	NN
cord-332422-s15o0hie	107	16	of	of	IN
cord-332422-s15o0hie	107	17	the	the	DT
cord-332422-s15o0hie	107	18	protein	protein	NN
cord-332422-s15o0hie	107	19	.	.	.
cord-332422-s15o0hie	108	1	The	the	DT
cord-332422-s15o0hie	108	2	C	c	NN
cord-332422-s15o0hie	108	3	-	-	HYPH
cord-332422-s15o0hie	108	4	terminus	terminus	NN
cord-332422-s15o0hie	108	5	of	of	IN
cord-332422-s15o0hie	108	6	SRB1	SRB1	NNP
cord-332422-s15o0hie	108	7	has	have	VBZ
cord-332422-s15o0hie	108	8	recently	recently	RB
cord-332422-s15o0hie	108	9	been	be	VBN
cord-332422-s15o0hie	108	10	shown	show	VBN
cord-332422-s15o0hie	108	11	to	to	TO
cord-332422-s15o0hie	108	12	play	play	VB
cord-332422-s15o0hie	108	13	a	a	DT
cord-332422-s15o0hie	108	14	role	role	NN
cord-332422-s15o0hie	108	15	in	in	IN
cord-332422-s15o0hie	108	16	HCV	HCV	NNP
cord-332422-s15o0hie	108	17	entry	entry	NN
cord-332422-s15o0hie	108	18	[	[	-LRB-
cord-332422-s15o0hie	108	19	29	29	CD
cord-332422-s15o0hie	108	20	]	]	-RRB-
cord-332422-s15o0hie	108	21	.	.	.
cord-332422-s15o0hie	109	1	Deletion	deletion	NN
cord-332422-s15o0hie	109	2	of	of	IN
cord-332422-s15o0hie	109	3	this	this	DT
cord-332422-s15o0hie	109	4	domain	domain	NN
cord-332422-s15o0hie	109	5	or	or	CC
cord-332422-s15o0hie	109	6	introduction	introduction	NN
cord-332422-s15o0hie	109	7	of	of	IN
cord-332422-s15o0hie	109	8	the	the	DT
cord-332422-s15o0hie	109	9	endocytosis	endocytosis	NN
cord-332422-s15o0hie	109	10	motif	motif	NN
cord-332422-s15o0hie	109	11	of	of	IN
cord-332422-s15o0hie	109	12	SRB2	SRB2	NNP
cord-332422-s15o0hie	109	13	into	into	IN
cord-332422-s15o0hie	109	14	SRB1	SRB1	NNP
cord-332422-s15o0hie	109	15	impairs	impair	VBZ
cord-332422-s15o0hie	109	16	HCV	HCV	NNP
cord-332422-s15o0hie	109	17	entry	entry	NN
cord-332422-s15o0hie	109	18	.	.	.
cord-332422-s15o0hie	110	1	SRB1	SRB1	NNP
cord-332422-s15o0hie	110	2	is	be	VBZ
cord-332422-s15o0hie	110	3	known	know	VBN
cord-332422-s15o0hie	110	4	to	to	TO
cord-332422-s15o0hie	110	5	interact	interact	VB
cord-332422-s15o0hie	110	6	with	with	IN
cord-332422-s15o0hie	110	7	the	the	DT
cord-332422-s15o0hie	110	8	cytoplasmic	cytoplasmic	JJ
cord-332422-s15o0hie	110	9	adaptor	adaptor	NN
cord-332422-s15o0hie	110	10	molecule	molecule	NN
cord-332422-s15o0hie	110	11	PDZK1	PDZK1	NNP
cord-332422-s15o0hie	110	12	via	via	IN
cord-332422-s15o0hie	110	13	an	an	DT
cord-332422-s15o0hie	110	14	AKL	AKL	NNP
cord-332422-s15o0hie	110	15	motif	motif	NN
cord-332422-s15o0hie	110	16	in	in	IN
cord-332422-s15o0hie	110	17	its	-PRON-	PRP$
cord-332422-s15o0hie	110	18	C	c	NN
cord-332422-s15o0hie	110	19	-	-	HYPH
cord-332422-s15o0hie	110	20	terminal	terminal	NN
cord-332422-s15o0hie	110	21	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	110	22	tail	tail	NN
cord-332422-s15o0hie	110	23	.	.	.
cord-332422-s15o0hie	111	1	This	this	DT
cord-332422-s15o0hie	111	2	interaction	interaction	NN
cord-332422-s15o0hie	111	3	is	be	VBZ
cord-332422-s15o0hie	111	4	involved	involve	VBN
cord-332422-s15o0hie	111	5	in	in	IN
cord-332422-s15o0hie	111	6	SRB1	SRB1	NNP
cord-332422-s15o0hie	111	7	stability	stability	NN
cord-332422-s15o0hie	111	8	in	in	IN
cord-332422-s15o0hie	111	9	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	111	10	and	and	CC
cord-332422-s15o0hie	111	11	it	-PRON-	PRP
cord-332422-s15o0hie	111	12	has	have	VBZ
cord-332422-s15o0hie	111	13	recently	recently	RB
cord-332422-s15o0hie	111	14	been	be	VBN
cord-332422-s15o0hie	111	15	shown	show	VBN
cord-332422-s15o0hie	111	16	that	that	IN
cord-332422-s15o0hie	111	17	PDZK1	PDZK1	NNP
cord-332422-s15o0hie	111	18	plays	play	VBZ
cord-332422-s15o0hie	111	19	an	an	DT
cord-332422-s15o0hie	111	20	indirect	indirect	JJ
cord-332422-s15o0hie	111	21	role	role	NN
cord-332422-s15o0hie	111	22	in	in	IN
cord-332422-s15o0hie	111	23	HCV	HCV	NNP
cord-332422-s15o0hie	111	24	entry	entry	NN
cord-332422-s15o0hie	111	25	via	via	IN
cord-332422-s15o0hie	111	26	its	-PRON-	PRP$
cord-332422-s15o0hie	111	27	ability	ability	NN
cord-332422-s15o0hie	111	28	to	to	TO
cord-332422-s15o0hie	111	29	interact	interact	VB
cord-332422-s15o0hie	111	30	with	with	IN
cord-332422-s15o0hie	111	31	SRB1	SRB1	NNP
cord-332422-s15o0hie	111	32	,	,	,
cord-332422-s15o0hie	111	33	which	which	WDT
cord-332422-s15o0hie	111	34	leads	lead	VBZ
cord-332422-s15o0hie	111	35	to	to	IN
cord-332422-s15o0hie	111	36	an	an	DT
cord-332422-s15o0hie	111	37	enhancement	enhancement	NN
cord-332422-s15o0hie	111	38	of	of	IN
cord-332422-s15o0hie	111	39	its	-PRON-	PRP$
cord-332422-s15o0hie	111	40	activity	activity	NN
cord-332422-s15o0hie	111	41	as	as	IN
cord-332422-s15o0hie	111	42	an	an	DT
cord-332422-s15o0hie	111	43	HCV	HCV	NNP
cord-332422-s15o0hie	111	44	entry	entry	NN
cord-332422-s15o0hie	111	45	factor	factor	NN
cord-332422-s15o0hie	111	46	[	[	-LRB-
cord-332422-s15o0hie	111	47	30	30	CD
cord-332422-s15o0hie	111	48	]	]	-RRB-
cord-332422-s15o0hie	111	49	.	.	.
cord-332422-s15o0hie	112	1	Some	some	DT
cord-332422-s15o0hie	112	2	SRB1	SRB1	NNP
cord-332422-s15o0hie	112	3	ligands	ligand	NNS
cord-332422-s15o0hie	112	4	are	be	VBP
cord-332422-s15o0hie	112	5	known	know	VBN
cord-332422-s15o0hie	112	6	to	to	TO
cord-332422-s15o0hie	112	7	affect	affect	VB
cord-332422-s15o0hie	112	8	HCV	HCV	NNP
cord-332422-s15o0hie	112	9	infection	infection	NN
cord-332422-s15o0hie	112	10	(	(	-LRB-
cord-332422-s15o0hie	112	11	reviewed	review	VBN
cord-332422-s15o0hie	112	12	in	in	IN
cord-332422-s15o0hie	112	13	[	[	-LRB-
cord-332422-s15o0hie	112	14	5	5	CD
cord-332422-s15o0hie	112	15	]	]	-RRB-
cord-332422-s15o0hie	112	16	)	)	-RRB-
cord-332422-s15o0hie	112	17	,	,	,
cord-332422-s15o0hie	112	18	notably	notably	RB
cord-332422-s15o0hie	112	19	HDL	HDL	NNP
cord-332422-s15o0hie	112	20	enhances	enhance	VBZ
cord-332422-s15o0hie	112	21	infection	infection	NN
cord-332422-s15o0hie	112	22	by	by	IN
cord-332422-s15o0hie	112	23	accelerating	accelerate	VBG
cord-332422-s15o0hie	112	24	viral	viral	JJ
cord-332422-s15o0hie	112	25	entry	entry	NN
cord-332422-s15o0hie	112	26	.	.	.
cord-332422-s15o0hie	113	1	This	this	DT
cord-332422-s15o0hie	113	2	mechanism	mechanism	NN
cord-332422-s15o0hie	113	3	depends	depend	VBZ
cord-332422-s15o0hie	113	4	not	not	RB
cord-332422-s15o0hie	113	5	only	only	RB
cord-332422-s15o0hie	113	6	on	on	IN
cord-332422-s15o0hie	113	7	the	the	DT
cord-332422-s15o0hie	113	8	lipid	lipid	NN
cord-332422-s15o0hie	113	9	transfer	transfer	NN
cord-332422-s15o0hie	113	10	activity	activity	NN
cord-332422-s15o0hie	113	11	of	of	IN
cord-332422-s15o0hie	113	12	SRB1	SRB1	NNP
cord-332422-s15o0hie	113	13	,	,	,
cord-332422-s15o0hie	113	14	but	but	CC
cord-332422-s15o0hie	113	15	also	also	RB
cord-332422-s15o0hie	113	16	on	on	IN
cord-332422-s15o0hie	113	17	the	the	DT
cord-332422-s15o0hie	113	18	presence	presence	NN
cord-332422-s15o0hie	113	19	of	of	IN
cord-332422-s15o0hie	113	20	CD81	CD81	NNP
cord-332422-s15o0hie	113	21	[	[	-LRB-
cord-332422-s15o0hie	113	22	31	31	CD
cord-332422-s15o0hie	113	23	]	]	-RRB-
cord-332422-s15o0hie	113	24	,	,	,
cord-332422-s15o0hie	113	25	suggesting	suggest	VBG
cord-332422-s15o0hie	113	26	that	that	IN
cord-332422-s15o0hie	113	27	an	an	DT
cord-332422-s15o0hie	113	28	interplay	interplay	NN
cord-332422-s15o0hie	113	29	between	between	IN
cord-332422-s15o0hie	113	30	SRB1	SRB1	NNP
cord-332422-s15o0hie	113	31	and	and	CC
cord-332422-s15o0hie	113	32	CD81	CD81	NNP
cord-332422-s15o0hie	113	33	occurs	occur	VBZ
cord-332422-s15o0hie	113	34	during	during	IN
cord-332422-s15o0hie	113	35	HCV	HCV	NNP
cord-332422-s15o0hie	113	36	entry	entry	NN
cord-332422-s15o0hie	113	37	.	.	.
cord-332422-s15o0hie	114	1	It	-PRON-	PRP
cord-332422-s15o0hie	114	2	is	be	VBZ
cord-332422-s15o0hie	114	3	also	also	RB
cord-332422-s15o0hie	114	4	possible	possible	JJ
cord-332422-s15o0hie	114	5	that	that	IN
cord-332422-s15o0hie	114	6	lipid	lipid	NN
cord-332422-s15o0hie	114	7	transfer	transfer	NN
cord-332422-s15o0hie	114	8	by	by	IN
cord-332422-s15o0hie	114	9	SRB1	SRB1	NNP
cord-332422-s15o0hie	114	10	changes	change	VBZ
cord-332422-s15o0hie	114	11	the	the	DT
cord-332422-s15o0hie	114	12	membrane	membrane	NN
cord-332422-s15o0hie	114	13	lipid	lipid	NN
cord-332422-s15o0hie	114	14	composition	composition	NN
cord-332422-s15o0hie	114	15	,	,	,
cord-332422-s15o0hie	114	16	which	which	WDT
cord-332422-s15o0hie	114	17	in	in	IN
cord-332422-s15o0hie	114	18	turn	turn	NN
cord-332422-s15o0hie	114	19	may	may	MD
cord-332422-s15o0hie	114	20	affect	affect	VB
cord-332422-s15o0hie	114	21	HCV	HCV	NNP
cord-332422-s15o0hie	114	22	infection	infection	NN
cord-332422-s15o0hie	114	23	.	.	.
cord-332422-s15o0hie	115	1	In	in	IN
cord-332422-s15o0hie	115	2	addition	addition	NN
cord-332422-s15o0hie	115	3	to	to	IN
cord-332422-s15o0hie	115	4	the	the	DT
cord-332422-s15o0hie	115	5	direct	direct	JJ
cord-332422-s15o0hie	115	6	binding	binding	NN
cord-332422-s15o0hie	115	7	of	of	IN
cord-332422-s15o0hie	115	8	soluble	soluble	JJ
cord-332422-s15o0hie	115	9	E2	e2	NN
cord-332422-s15o0hie	115	10	to	to	IN
cord-332422-s15o0hie	115	11	SRB1	SRB1	NNP
cord-332422-s15o0hie	115	12	,	,	,
cord-332422-s15o0hie	115	13	it	-PRON-	PRP
cord-332422-s15o0hie	115	14	has	have	VBZ
cord-332422-s15o0hie	115	15	also	also	RB
cord-332422-s15o0hie	115	16	been	be	VBN
cord-332422-s15o0hie	115	17	suggested	suggest	VBN
cord-332422-s15o0hie	115	18	that	that	IN
cord-332422-s15o0hie	115	19	the	the	DT
cord-332422-s15o0hie	115	20	virus	virus	NN
cord-332422-s15o0hie	115	21	can	can	MD
cord-332422-s15o0hie	115	22	bind	bind	VB
cord-332422-s15o0hie	115	23	SRB1	SRB1	NNP
cord-332422-s15o0hie	115	24	via	via	IN
cord-332422-s15o0hie	115	25	its	-PRON-	PRP$
cord-332422-s15o0hie	115	26	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	115	27	component	component	NN
cord-332422-s15o0hie	115	28	[	[	-LRB-
cord-332422-s15o0hie	115	29	32	32	CD
cord-332422-s15o0hie	115	30	]	]	-RRB-
cord-332422-s15o0hie	115	31	.	.	.
cord-332422-s15o0hie	116	1	Together	together	RB
cord-332422-s15o0hie	116	2	with	with	IN
cord-332422-s15o0hie	116	3	the	the	DT
cord-332422-s15o0hie	116	4	observation	observation	NN
cord-332422-s15o0hie	116	5	that	that	IN
cord-332422-s15o0hie	116	6	it	-PRON-	PRP
cord-332422-s15o0hie	116	7	interacts	interact	VBZ
cord-332422-s15o0hie	116	8	with	with	IN
cord-332422-s15o0hie	116	9	HCV	HCV	NNP
cord-332422-s15o0hie	116	10	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	116	11	E2	E2	NNP
cord-332422-s15o0hie	116	12	,	,	,
cord-332422-s15o0hie	116	13	the	the	DT
cord-332422-s15o0hie	116	14	role	role	NN
cord-332422-s15o0hie	116	15	of	of	IN
cord-332422-s15o0hie	116	16	SRB1	SRB1	NNP
cord-332422-s15o0hie	116	17	in	in	IN
cord-332422-s15o0hie	116	18	lipid	lipid	NN
cord-332422-s15o0hie	116	19	metabolism	metabolism	NN
cord-332422-s15o0hie	116	20	has	have	VBZ
cord-332422-s15o0hie	116	21	suggested	suggest	VBN
cord-332422-s15o0hie	116	22	that	that	IN
cord-332422-s15o0hie	116	23	this	this	DT
cord-332422-s15o0hie	116	24	entry	entry	NN
cord-332422-s15o0hie	116	25	factor	factor	NN
cord-332422-s15o0hie	116	26	may	may	MD
cord-332422-s15o0hie	116	27	play	play	VB
cord-332422-s15o0hie	116	28	a	a	DT
cord-332422-s15o0hie	116	29	dual	dual	JJ
cord-332422-s15o0hie	116	30	role	role	NN
cord-332422-s15o0hie	116	31	during	during	IN
cord-332422-s15o0hie	116	32	the	the	DT
cord-332422-s15o0hie	116	33	early	early	JJ
cord-332422-s15o0hie	116	34	steps	step	NNS
cord-332422-s15o0hie	116	35	of	of	IN
cord-332422-s15o0hie	116	36	the	the	DT
cord-332422-s15o0hie	116	37	HCV	HCV	NNP
cord-332422-s15o0hie	116	38	life	life	NN
cord-332422-s15o0hie	116	39	cycle	cycle	NN
cord-332422-s15o0hie	116	40	[	[	-LRB-
cord-332422-s15o0hie	116	41	28	28	CD
cord-332422-s15o0hie	116	42	,	,	,
cord-332422-s15o0hie	116	43	31	31	CD
cord-332422-s15o0hie	116	44	]	]	-RRB-
cord-332422-s15o0hie	116	45	.	.	.
cord-332422-s15o0hie	117	1	More	more	RBR
cord-332422-s15o0hie	117	2	recently	recently	RB
cord-332422-s15o0hie	117	3	,	,	,
cord-332422-s15o0hie	117	4	the	the	DT
cord-332422-s15o0hie	117	5	role	role	NN
cord-332422-s15o0hie	117	6	of	of	IN
cord-332422-s15o0hie	117	7	SRB1	SRB1	NNP
cord-332422-s15o0hie	117	8	in	in	IN
cord-332422-s15o0hie	117	9	HCV	HCV	NNP
cord-332422-s15o0hie	117	10	uptake	uptake	NN
cord-332422-s15o0hie	117	11	has	have	VBZ
cord-332422-s15o0hie	117	12	been	be	VBN
cord-332422-s15o0hie	117	13	confirmed	confirm	VBN
cord-332422-s15o0hie	117	14	in	in	IN
cord-332422-s15o0hie	117	15	vivo	vivo	NN
cord-332422-s15o0hie	117	16	in	in	IN
cord-332422-s15o0hie	117	17	a	a	DT
cord-332422-s15o0hie	117	18	genetically	genetically	RB
cord-332422-s15o0hie	117	19	humanized	humanize	VBN
cord-332422-s15o0hie	117	20	mouse	mouse	NN
cord-332422-s15o0hie	117	21	model	model	NN
cord-332422-s15o0hie	117	22	for	for	IN
cord-332422-s15o0hie	117	23	HCV	HCV	NNP
cord-332422-s15o0hie	117	24	infection	infection	NN
cord-332422-s15o0hie	117	25	[	[	-LRB-
cord-332422-s15o0hie	117	26	33	33	CD
cord-332422-s15o0hie	117	27	]	]	-RRB-
cord-332422-s15o0hie	117	28	.	.	.
cord-332422-s15o0hie	118	1	CD81	CD81	NNP
cord-332422-s15o0hie	118	2	is	be	VBZ
cord-332422-s15o0hie	118	3	a	a	DT
cord-332422-s15o0hie	118	4	member	member	NN
cord-332422-s15o0hie	118	5	of	of	IN
cord-332422-s15o0hie	118	6	the	the	DT
cord-332422-s15o0hie	118	7	tetraspanin	tetraspanin	NNP
cord-332422-s15o0hie	118	8	family	family	NN
cord-332422-s15o0hie	118	9	.	.	.
cord-332422-s15o0hie	119	1	Like	like	IN
cord-332422-s15o0hie	119	2	the	the	DT
cord-332422-s15o0hie	119	3	other	other	JJ
cord-332422-s15o0hie	119	4	members	member	NNS
cord-332422-s15o0hie	119	5	of	of	IN
cord-332422-s15o0hie	119	6	this	this	DT
cord-332422-s15o0hie	119	7	family	family	NN
cord-332422-s15o0hie	119	8	,	,	,
cord-332422-s15o0hie	119	9	it	-PRON-	PRP
cord-332422-s15o0hie	119	10	contains	contain	VBZ
cord-332422-s15o0hie	119	11	4	4	CD
cord-332422-s15o0hie	119	12	transmembrane	transmembrane	NN
cord-332422-s15o0hie	119	13	domains	domain	NNS
cord-332422-s15o0hie	119	14	,	,	,
cord-332422-s15o0hie	119	15	a	a	DT
cord-332422-s15o0hie	119	16	small	small	JJ
cord-332422-s15o0hie	119	17	(	(	-LRB-
cord-332422-s15o0hie	119	18	SEL	SEL	NNP
cord-332422-s15o0hie	119	19	)	)	-RRB-
cord-332422-s15o0hie	119	20	and	and	CC
cord-332422-s15o0hie	119	21	a	a	DT
cord-332422-s15o0hie	119	22	large	large	JJ
cord-332422-s15o0hie	119	23	extracellular	extracellular	JJ
cord-332422-s15o0hie	119	24	loop	loop	NN
cord-332422-s15o0hie	119	25	(	(	-LRB-
cord-332422-s15o0hie	119	26	LEL	LEL	NNP
cord-332422-s15o0hie	119	27	)	)	-RRB-
cord-332422-s15o0hie	120	1	(	(	-LRB-
cord-332422-s15o0hie	120	2	Figure	figure	NN
cord-332422-s15o0hie	120	3	2	2	CD
cord-332422-s15o0hie	120	4	)	)	-RRB-
cord-332422-s15o0hie	120	5	.	.	.
cord-332422-s15o0hie	121	1	Tetraspanins	tetraspanin	NNS
cord-332422-s15o0hie	121	2	are	be	VBP
cord-332422-s15o0hie	121	3	involved	involve	VBN
cord-332422-s15o0hie	121	4	in	in	IN
cord-332422-s15o0hie	121	5	many	many	JJ
cord-332422-s15o0hie	121	6	cell	cell	NN
cord-332422-s15o0hie	121	7	functions	function	NNS
cord-332422-s15o0hie	121	8	such	such	JJ
cord-332422-s15o0hie	121	9	as	as	IN
cord-332422-s15o0hie	121	10	adhesion	adhesion	NN
cord-332422-s15o0hie	121	11	,	,	,
cord-332422-s15o0hie	121	12	morphology	morphology	NN
cord-332422-s15o0hie	121	13	,	,	,
cord-332422-s15o0hie	121	14	proliferation	proliferation	NN
cord-332422-s15o0hie	121	15	and	and	CC
cord-332422-s15o0hie	121	16	differentiation	differentiation	NN
cord-332422-s15o0hie	121	17	.	.	.
cord-332422-s15o0hie	122	1	They	-PRON-	PRP
cord-332422-s15o0hie	122	2	are	be	VBP
cord-332422-s15o0hie	122	3	enriched	enrich	VBN
cord-332422-s15o0hie	122	4	in	in	IN
cord-332422-s15o0hie	122	5	specific	specific	JJ
cord-332422-s15o0hie	122	6	membrane	membrane	NN
cord-332422-s15o0hie	122	7	microdomains	microdomain	NNS
cord-332422-s15o0hie	122	8	called	call	VBN
cord-332422-s15o0hie	122	9	tetraspanin	tetraspanin	NNP
cord-332422-s15o0hie	122	10	-	-	HYPH
cord-332422-s15o0hie	122	11	enriched	enrich	VBN
cord-332422-s15o0hie	122	12	microdomains	microdomain	NNS
cord-332422-s15o0hie	122	13	(	(	-LRB-
cord-332422-s15o0hie	122	14	TEMs	TEMs	NNP
cord-332422-s15o0hie	122	15	)	)	-RRB-
cord-332422-s15o0hie	122	16	,	,	,
cord-332422-s15o0hie	122	17	which	which	WDT
cord-332422-s15o0hie	122	18	differ	differ	VBP
cord-332422-s15o0hie	122	19	from	from	IN
cord-332422-s15o0hie	122	20	conventional	conventional	JJ
cord-332422-s15o0hie	122	21	raft	raft	NN
cord-332422-s15o0hie	122	22	domains	domain	NNS
cord-332422-s15o0hie	122	23	,	,	,
cord-332422-s15o0hie	122	24	but	but	CC
cord-332422-s15o0hie	122	25	the	the	DT
cord-332422-s15o0hie	122	26	organization	organization	NN
cord-332422-s15o0hie	122	27	of	of	IN
cord-332422-s15o0hie	122	28	which	which	WDT
cord-332422-s15o0hie	122	29	is	be	VBZ
cord-332422-s15o0hie	122	30	dependent	dependent	JJ
cord-332422-s15o0hie	122	31	on	on	IN
cord-332422-s15o0hie	122	32	cholesterol	cholesterol	NN
cord-332422-s15o0hie	122	33	.	.	.
cord-332422-s15o0hie	123	1	Tetraspanins	tetraspanin	NNS
cord-332422-s15o0hie	123	2	interact	interact	VBP
cord-332422-s15o0hie	123	3	with	with	IN
cord-332422-s15o0hie	123	4	partner	partner	NN
cord-332422-s15o0hie	123	5	proteins	protein	NNS
cord-332422-s15o0hie	123	6	to	to	TO
cord-332422-s15o0hie	123	7	form	form	VB
cord-332422-s15o0hie	123	8	primary	primary	JJ
cord-332422-s15o0hie	123	9	complexes	complex	NNS
cord-332422-s15o0hie	123	10	which	which	WDT
cord-332422-s15o0hie	123	11	can	can	MD
cord-332422-s15o0hie	123	12	interact	interact	VB
cord-332422-s15o0hie	123	13	together	together	RB
cord-332422-s15o0hie	123	14	to	to	TO
cord-332422-s15o0hie	123	15	form	form	VB
cord-332422-s15o0hie	123	16	a	a	DT
cord-332422-s15o0hie	123	17	network	network	NN
cord-332422-s15o0hie	123	18	of	of	IN
cord-332422-s15o0hie	123	19	interactions	interaction	NNS
cord-332422-s15o0hie	123	20	within	within	IN
cord-332422-s15o0hie	123	21	TEMs	tem	NNS
cord-332422-s15o0hie	123	22	.	.	.
cord-332422-s15o0hie	124	1	The	the	DT
cord-332422-s15o0hie	124	2	role	role	NN
cord-332422-s15o0hie	124	3	of	of	IN
cord-332422-s15o0hie	124	4	CD81	CD81	NNP
cord-332422-s15o0hie	124	5	in	in	IN
cord-332422-s15o0hie	124	6	HCV	HCV	NNP
cord-332422-s15o0hie	124	7	entry	entry	NN
cord-332422-s15o0hie	124	8	was	be	VBD
cord-332422-s15o0hie	124	9	first	first	RB
cord-332422-s15o0hie	124	10	suggested	suggest	VBN
cord-332422-s15o0hie	124	11	after	after	IN
cord-332422-s15o0hie	124	12	the	the	DT
cord-332422-s15o0hie	124	13	demonstration	demonstration	NN
cord-332422-s15o0hie	124	14	that	that	WDT
cord-332422-s15o0hie	124	15	it	-PRON-	PRP
cord-332422-s15o0hie	124	16	interacts	interact	VBZ
cord-332422-s15o0hie	124	17	with	with	IN
cord-332422-s15o0hie	124	18	a	a	DT
cord-332422-s15o0hie	124	19	soluble	soluble	JJ
cord-332422-s15o0hie	124	20	form	form	NN
cord-332422-s15o0hie	124	21	.	.	.
cord-332422-s15o0hie	125	1	The	the	DT
cord-332422-s15o0hie	125	2	virus	virus	NN
cord-332422-s15o0hie	125	3	is	be	VBZ
cord-332422-s15o0hie	125	4	internalized	internalize	VBN
cord-332422-s15o0hie	125	5	by	by	IN
cord-332422-s15o0hie	125	6	clathrin	clathrin	NN
cord-332422-s15o0hie	125	7	-	-	HYPH
cord-332422-s15o0hie	125	8	mediated	mediate	VBN
cord-332422-s15o0hie	125	9	endocytosis	endocytosis	NN
cord-332422-s15o0hie	125	10	and	and	CC
cord-332422-s15o0hie	125	11	fuses	fuse	NNS
cord-332422-s15o0hie	125	12	in	in	IN
cord-332422-s15o0hie	125	13	early	early	JJ
cord-332422-s15o0hie	125	14	endosomes	endosome	NNS
cord-332422-s15o0hie	125	15	delivering	deliver	VBG
cord-332422-s15o0hie	125	16	its	-PRON-	PRP$
cord-332422-s15o0hie	125	17	nucleocapsid	nucleocapsid	NN
cord-332422-s15o0hie	125	18	into	into	IN
cord-332422-s15o0hie	125	19	the	the	DT
cord-332422-s15o0hie	125	20	cytosol	cytosol	NN
cord-332422-s15o0hie	125	21	.	.	.
cord-332422-s15o0hie	126	1	The	the	DT
cord-332422-s15o0hie	126	2	genome	genome	NN
cord-332422-s15o0hie	126	3	of	of	IN
cord-332422-s15o0hie	126	4	the	the	DT
cord-332422-s15o0hie	126	5	virus	virus	NN
cord-332422-s15o0hie	126	6	is	be	VBZ
cord-332422-s15o0hie	126	7	then	then	RB
cord-332422-s15o0hie	126	8	released	release	VBN
cord-332422-s15o0hie	126	9	and	and	CC
cord-332422-s15o0hie	126	10	translated	translate	VBN
cord-332422-s15o0hie	126	11	to	to	TO
cord-332422-s15o0hie	126	12	produce	produce	VB
cord-332422-s15o0hie	126	13	structural	structural	JJ
cord-332422-s15o0hie	126	14	and	and	CC
cord-332422-s15o0hie	126	15	non	non	JJ
cord-332422-s15o0hie	126	16	-	-	JJ
cord-332422-s15o0hie	126	17	structural	structural	JJ
cord-332422-s15o0hie	126	18	proteins	protein	NNS
cord-332422-s15o0hie	126	19	.	.	.
cord-332422-s15o0hie	127	1	The	the	DT
cord-332422-s15o0hie	127	2	non	non	JJ
cord-332422-s15o0hie	127	3	-	-	JJ
cord-332422-s15o0hie	127	4	structural	structural	JJ
cord-332422-s15o0hie	127	5	proteins	protein	NNS
cord-332422-s15o0hie	127	6	are	be	VBP
cord-332422-s15o0hie	127	7	involved	involve	VBN
cord-332422-s15o0hie	127	8	in	in	IN
cord-332422-s15o0hie	127	9	viral	viral	JJ
cord-332422-s15o0hie	127	10	genome	genome	NN
cord-332422-s15o0hie	127	11	replication	replication	NN
cord-332422-s15o0hie	127	12	.	.	.
cord-332422-s15o0hie	128	1	The	the	DT
cord-332422-s15o0hie	128	2	mechanism	mechanism	NN
cord-332422-s15o0hie	128	3	of	of	IN
cord-332422-s15o0hie	128	4	assembly	assembly	NN
cord-332422-s15o0hie	128	5	is	be	VBZ
cord-332422-s15o0hie	128	6	not	not	RB
cord-332422-s15o0hie	128	7	completely	completely	RB
cord-332422-s15o0hie	128	8	understood	understand	VBN
cord-332422-s15o0hie	128	9	but	but	CC
cord-332422-s15o0hie	128	10	it	-PRON-	PRP
cord-332422-s15o0hie	128	11	is	be	VBZ
cord-332422-s15o0hie	128	12	closely	closely	RB
cord-332422-s15o0hie	128	13	linked	link	VBN
cord-332422-s15o0hie	128	14	to	to	IN
cord-332422-s15o0hie	128	15	endoplasmic	endoplasmic	NN
cord-332422-s15o0hie	128	16	reticulum	reticulum	NN
cord-332422-s15o0hie	128	17	(	(	-LRB-
cord-332422-s15o0hie	128	18	ER	ER	NNP
cord-332422-s15o0hie	128	19	)	)	-RRB-
cord-332422-s15o0hie	128	20	and	and	CC
cord-332422-s15o0hie	128	21	lipid	lipid	NN
cord-332422-s15o0hie	128	22	droplets	droplet	NNS
cord-332422-s15o0hie	128	23	(	(	-LRB-
cord-332422-s15o0hie	128	24	LD	LD	NNP
cord-332422-s15o0hie	128	25	)	)	-RRB-
cord-332422-s15o0hie	128	26	.	.	.
cord-332422-s15o0hie	129	1	The	the	DT
cord-332422-s15o0hie	129	2	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	129	3	-	-	HYPH
cord-332422-s15o0hie	129	4	associated	associate	VBN
cord-332422-s15o0hie	129	5	virus	virus	NN
cord-332422-s15o0hie	129	6	is	be	VBZ
cord-332422-s15o0hie	129	7	then	then	RB
cord-332422-s15o0hie	129	8	released	release	VBN
cord-332422-s15o0hie	129	9	in	in	IN
cord-332422-s15o0hie	129	10	the	the	DT
cord-332422-s15o0hie	129	11	surrounding	surround	VBG
cord-332422-s15o0hie	129	12	medium	medium	NN
cord-332422-s15o0hie	129	13	to	to	TO
cord-332422-s15o0hie	129	14	infect	infect	VB
cord-332422-s15o0hie	129	15	new	new	JJ
cord-332422-s15o0hie	129	16	cells	cell	NNS
cord-332422-s15o0hie	129	17	.	.	.
cord-332422-s15o0hie	130	1	The	the	DT
cord-332422-s15o0hie	130	2	virus	virus	NN
cord-332422-s15o0hie	130	3	can	can	MD
cord-332422-s15o0hie	130	4	also	also	RB
cord-332422-s15o0hie	130	5	be	be	VB
cord-332422-s15o0hie	130	6	transferred	transfer	VBN
cord-332422-s15o0hie	130	7	directly	directly	RB
cord-332422-s15o0hie	130	8	to	to	IN
cord-332422-s15o0hie	130	9	the	the	DT
cord-332422-s15o0hie	130	10	neighboring	neighboring	NN
cord-332422-s15o0hie	130	11	cells	cell	NNS
cord-332422-s15o0hie	130	12	by	by	IN
cord-332422-s15o0hie	130	13	cell	cell	NN
cord-332422-s15o0hie	130	14	-	-	HYPH
cord-332422-s15o0hie	130	15	to	to	IN
cord-332422-s15o0hie	130	16	-	-	HYPH
cord-332422-s15o0hie	130	17	cell	cell	NN
cord-332422-s15o0hie	130	18	transmission	transmission	NN
cord-332422-s15o0hie	130	19	(	(	-LRB-
cord-332422-s15o0hie	130	20	green	green	JJ
cord-332422-s15o0hie	130	21	arrow	arrow	NN
cord-332422-s15o0hie	130	22	)	)	-RRB-
cord-332422-s15o0hie	130	23	.	.	.
cord-332422-s15o0hie	131	1	BC	BC	NNP
cord-332422-s15o0hie	131	2	,	,	,
cord-332422-s15o0hie	131	3	bile	bile	NN
cord-332422-s15o0hie	131	4	canaliculi	canaliculus	NNS
cord-332422-s15o0hie	131	5	.	.	.
cord-332422-s15o0hie	132	1	of	of	IN
cord-332422-s15o0hie	132	2	E2	E2	NNP
cord-332422-s15o0hie	132	3	[	[	-LRB-
cord-332422-s15o0hie	132	4	34	34	CD
cord-332422-s15o0hie	132	5	]	]	-RRB-
cord-332422-s15o0hie	132	6	.	.	.
cord-332422-s15o0hie	133	1	Subsequently	subsequently	RB
cord-332422-s15o0hie	133	2	,	,	,
cord-332422-s15o0hie	133	3	it	-PRON-	PRP
cord-332422-s15o0hie	133	4	was	be	VBD
cord-332422-s15o0hie	133	5	extensively	extensively	RB
cord-332422-s15o0hie	133	6	confirmed	confirm	VBN
cord-332422-s15o0hie	133	7	in	in	IN
cord-332422-s15o0hie	133	8	HCVpp	HCVpp	NNP
cord-332422-s15o0hie	133	9	,	,	,
cord-332422-s15o0hie	133	10	HCVcc	HCVcc	NNP
cord-332422-s15o0hie	133	11	,	,	,
cord-332422-s15o0hie	133	12	HCV	HCV	NNP
cord-332422-s15o0hie	133	13	isolated	isolate	VBN
cord-332422-s15o0hie	133	14	from	from	IN
cord-332422-s15o0hie	133	15	patient	patient	NN
cord-332422-s15o0hie	133	16	and	and	CC
cord-332422-s15o0hie	133	17	in	in	IN
cord-332422-s15o0hie	133	18	a	a	DT
cord-332422-s15o0hie	133	19	humanized	humanized	JJ
cord-332422-s15o0hie	133	20	mouse	mouse	NN
cord-332422-s15o0hie	133	21	model	model	NN
cord-332422-s15o0hie	133	22	(	(	-LRB-
cord-332422-s15o0hie	133	23	reviewed	review	VBN
cord-332422-s15o0hie	133	24	in	in	IN
cord-332422-s15o0hie	133	25	[	[	-LRB-
cord-332422-s15o0hie	133	26	5	5	CD
cord-332422-s15o0hie	133	27	]	]	-RRB-
cord-332422-s15o0hie	133	28	)	)	-RRB-
cord-332422-s15o0hie	133	29	.	.	.
cord-332422-s15o0hie	134	1	The	the	DT
cord-332422-s15o0hie	134	2	CD81	CD81	NNP
cord-332422-s15o0hie	134	3	binding	bind	VBG
cord-332422-s15o0hie	134	4	site	site	NN
cord-332422-s15o0hie	134	5	for	for	IN
cord-332422-s15o0hie	134	6	E2	E2	NNP
cord-332422-s15o0hie	134	7	has	have	VBZ
cord-332422-s15o0hie	134	8	been	be	VBN
cord-332422-s15o0hie	134	9	localized	localize	VBN
cord-332422-s15o0hie	134	10	within	within	IN
cord-332422-s15o0hie	134	11	the	the	DT
cord-332422-s15o0hie	134	12	LEL	LEL	NNP
cord-332422-s15o0hie	134	13	[	[	-LRB-
cord-332422-s15o0hie	134	14	34	34	CD
cord-332422-s15o0hie	134	15	]	]	-RRB-
cord-332422-s15o0hie	134	16	and	and	CC
cord-332422-s15o0hie	134	17	characterization	characterization	NN
cord-332422-s15o0hie	134	18	of	of	IN
cord-332422-s15o0hie	134	19	chimeric	chimeric	JJ
cord-332422-s15o0hie	134	20	proteins	protein	NNS
cord-332422-s15o0hie	134	21	between	between	IN
cord-332422-s15o0hie	134	22	CD81	CD81	NNP
cord-332422-s15o0hie	134	23	and	and	CC
cord-332422-s15o0hie	134	24	CD9	CD9	NNP
cord-332422-s15o0hie	134	25	,	,	,
cord-332422-s15o0hie	134	26	a	a	DT
cord-332422-s15o0hie	134	27	related	related	JJ
cord-332422-s15o0hie	134	28	tetraspanin	tetraspanin	NNS
cord-332422-s15o0hie	134	29	,	,	,
cord-332422-s15o0hie	134	30	confirmed	confirm	VBD
cord-332422-s15o0hie	134	31	that	that	IN
cord-332422-s15o0hie	134	32	the	the	DT
cord-332422-s15o0hie	134	33	LEL	LEL	NNP
cord-332422-s15o0hie	134	34	sequence	sequence	NN
cord-332422-s15o0hie	134	35	is	be	VBZ
cord-332422-s15o0hie	134	36	the	the	DT
cord-332422-s15o0hie	134	37	region	region	NN
cord-332422-s15o0hie	134	38	of	of	IN
cord-332422-s15o0hie	134	39	CD81	CD81	NNP
cord-332422-s15o0hie	134	40	defining	define	VBG
cord-332422-s15o0hie	134	41	HCV	HCV	NNP
cord-332422-s15o0hie	134	42	entry	entry	NN
cord-332422-s15o0hie	134	43	[	[	-LRB-
cord-332422-s15o0hie	134	44	35	35	CD
cord-332422-s15o0hie	134	45	]	]	-RRB-
cord-332422-s15o0hie	134	46	,	,	,
cord-332422-s15o0hie	134	47	with	with	IN
cord-332422-s15o0hie	134	48	the	the	DT
cord-332422-s15o0hie	134	49	binding	binding	NN
cord-332422-s15o0hie	134	50	site	site	NN
cord-332422-s15o0hie	134	51	for	for	IN
cord-332422-s15o0hie	134	52	E2	E2	NNP
cord-332422-s15o0hie	134	53	having	have	VBG
cord-332422-s15o0hie	134	54	been	be	VBN
cord-332422-s15o0hie	134	55	mapped	map	VBN
cord-332422-s15o0hie	134	56	to	to	IN
cord-332422-s15o0hie	134	57	the	the	DT
cord-332422-s15o0hie	134	58	variable	variable	JJ
cord-332422-s15o0hie	134	59	double	double	JJ
cord-332422-s15o0hie	134	60	-	-	HYPH
cord-332422-s15o0hie	134	61	helix	helix	NN
cord-332422-s15o0hie	134	62	subdomain	subdomain	NN
cord-332422-s15o0hie	134	63	[	[	-LRB-
cord-332422-s15o0hie	134	64	36	36	CD
cord-332422-s15o0hie	134	65	]	]	-RRB-
cord-332422-s15o0hie	134	66	.	.	.
cord-332422-s15o0hie	135	1	Several	several	JJ
cord-332422-s15o0hie	135	2	studies	study	NNS
cord-332422-s15o0hie	135	3	have	have	VBP
cord-332422-s15o0hie	135	4	also	also	RB
cord-332422-s15o0hie	135	5	shown	show	VBN
cord-332422-s15o0hie	135	6	that	that	IN
cord-332422-s15o0hie	135	7	cell	cell	NN
cord-332422-s15o0hie	135	8	susceptibility	susceptibility	NN
cord-332422-s15o0hie	135	9	to	to	IN
cord-332422-s15o0hie	135	10	HCV	HCV	NNP
cord-332422-s15o0hie	135	11	infection	infection	NN
cord-332422-s15o0hie	135	12	is	be	VBZ
cord-332422-s15o0hie	135	13	closely	closely	RB
cord-332422-s15o0hie	135	14	related	related	JJ
cord-332422-s15o0hie	135	15	to	to	IN
cord-332422-s15o0hie	135	16	CD81	CD81	NNP
cord-332422-s15o0hie	135	17	expression	expression	NN
cord-332422-s15o0hie	135	18	level	level	NN
cord-332422-s15o0hie	135	19	[	[	-LRB-
cord-332422-s15o0hie	135	20	37	37	CD
cord-332422-s15o0hie	135	21	]	]	-RRB-
cord-332422-s15o0hie	135	22	[	[	-LRB-
cord-332422-s15o0hie	135	23	38	38	CD
cord-332422-s15o0hie	135	24	]	]	-RRB-
cord-332422-s15o0hie	135	25	[	[	-LRB-
cord-332422-s15o0hie	135	26	39	39	CD
cord-332422-s15o0hie	135	27	]	]	-RRB-
cord-332422-s15o0hie	135	28	.	.	.
cord-332422-s15o0hie	136	1	Since	since	IN
cord-332422-s15o0hie	136	2	tetraspanin	tetraspanin	NNS
cord-332422-s15o0hie	136	3	molecules	molecule	NNS
cord-332422-s15o0hie	136	4	are	be	VBP
cord-332422-s15o0hie	136	5	known	know	VBN
cord-332422-s15o0hie	136	6	to	to	TO
cord-332422-s15o0hie	136	7	interact	interact	VB
cord-332422-s15o0hie	136	8	with	with	IN
cord-332422-s15o0hie	136	9	other	other	JJ
cord-332422-s15o0hie	136	10	membrane	membrane	NN
cord-332422-s15o0hie	136	11	proteins	protein	NNS
cord-332422-s15o0hie	136	12	,	,	,
cord-332422-s15o0hie	136	13	named	name	VBN
cord-332422-s15o0hie	136	14	partners	partner	NNS
cord-332422-s15o0hie	136	15	,	,	,
cord-332422-s15o0hie	136	16	the	the	DT
cord-332422-s15o0hie	136	17	involvement	involvement	NN
cord-332422-s15o0hie	136	18	of	of	IN
cord-332422-s15o0hie	136	19	CD81	CD81	NNP
cord-332422-s15o0hie	136	20	partners	partner	NNS
cord-332422-s15o0hie	136	21	in	in	IN
cord-332422-s15o0hie	136	22	the	the	DT
cord-332422-s15o0hie	136	23	modulation	modulation	NN
cord-332422-s15o0hie	136	24	of	of	IN
cord-332422-s15o0hie	136	25	HCV	HCV	NNP
cord-332422-s15o0hie	136	26	entry	entry	NN
cord-332422-s15o0hie	136	27	has	have	VBZ
cord-332422-s15o0hie	136	28	been	be	VBN
cord-332422-s15o0hie	136	29	investigated	investigate	VBN
cord-332422-s15o0hie	136	30	.	.	.
cord-332422-s15o0hie	137	1	Indeed	indeed	RB
cord-332422-s15o0hie	137	2	,	,	,
cord-332422-s15o0hie	137	3	the	the	DT
cord-332422-s15o0hie	137	4	generation	generation	NN
cord-332422-s15o0hie	137	5	of	of	IN
cord-332422-s15o0hie	137	6	a	a	DT
cord-332422-s15o0hie	137	7	human	human	JJ
cord-332422-s15o0hie	137	8	cell	cell	NN
cord-332422-s15o0hie	137	9	line	line	NN
cord-332422-s15o0hie	137	10	expressing	express	VBG
cord-332422-s15o0hie	137	11	murine	murine	JJ
cord-332422-s15o0hie	137	12	CD81	CD81	NNP
cord-332422-s15o0hie	137	13	(	(	-LRB-
cord-332422-s15o0hie	137	14	mCD81	mCD81	NNP
cord-332422-s15o0hie	137	15	)	)	-RRB-
cord-332422-s15o0hie	137	16	permissive	permissive	JJ
cord-332422-s15o0hie	137	17	to	to	IN
cord-332422-s15o0hie	137	18	HCV	HCV	NNP
cord-332422-s15o0hie	137	19	infection	infection	NN
cord-332422-s15o0hie	137	20	has	have	VBZ
cord-332422-s15o0hie	137	21	allowed	allow	VBN
cord-332422-s15o0hie	137	22	for	for	IN
cord-332422-s15o0hie	137	23	the	the	DT
cord-332422-s15o0hie	137	24	analysis	analysis	NN
cord-332422-s15o0hie	137	25	of	of	IN
cord-332422-s15o0hie	137	26	the	the	DT
cord-332422-s15o0hie	137	27	role	role	NN
cord-332422-s15o0hie	137	28	of	of	IN
cord-332422-s15o0hie	137	29	TEM	tem	NN
cord-332422-s15o0hie	137	30	-	-	HYPH
cord-332422-s15o0hie	137	31	associated	associate	VBN
cord-332422-s15o0hie	137	32	CD81	CD81	NNP
cord-332422-s15o0hie	137	33	in	in	IN
cord-332422-s15o0hie	137	34	HCV	HCV	NNP
cord-332422-s15o0hie	137	35	infection	infection	NN
cord-332422-s15o0hie	137	36	[	[	-LRB-
cord-332422-s15o0hie	137	37	40	40	CD
cord-332422-s15o0hie	137	38	]	]	-RRB-
cord-332422-s15o0hie	137	39	.	.	.
cord-332422-s15o0hie	138	1	The	the	DT
cord-332422-s15o0hie	138	2	use	use	NN
cord-332422-s15o0hie	138	3	of	of	IN
cord-332422-s15o0hie	138	4	the	the	DT
cord-332422-s15o0hie	138	5	MT81w	MT81w	NNP
cord-332422-s15o0hie	138	6	antibody	antibody	NN
cord-332422-s15o0hie	138	7	,	,	,
cord-332422-s15o0hie	138	8	which	which	WDT
cord-332422-s15o0hie	138	9	only	only	RB
cord-332422-s15o0hie	138	10	recognizes	recognize	VBZ
cord-332422-s15o0hie	138	11	TEMassociated	temassociated	JJ
cord-332422-s15o0hie	138	12	mCD81	mCD81	NNS
cord-332422-s15o0hie	138	13	[	[	-LRB-
cord-332422-s15o0hie	138	14	41	41	CD
cord-332422-s15o0hie	138	15	]	]	-RRB-
cord-332422-s15o0hie	138	16	and	and	CC
cord-332422-s15o0hie	138	17	treatments	treatment	NNS
cord-332422-s15o0hie	138	18	with	with	IN
cord-332422-s15o0hie	138	19	methyl	methyl	NN
cord-332422-s15o0hie	138	20	-	-	HYPH
cord-332422-s15o0hie	138	21	bcyclo	bcyclo	NN
cord-332422-s15o0hie	138	22	-	-	HYPH
cord-332422-s15o0hie	138	23	dextrin	dextrin	NN
cord-332422-s15o0hie	138	24	or	or	CC
cord-332422-s15o0hie	138	25	sphingomyelinase	sphingomyelinase	NN
cord-332422-s15o0hie	138	26	showed	show	VBD
cord-332422-s15o0hie	138	27	that	that	IN
cord-332422-s15o0hie	138	28	TEMassociated	TEMassociated	NNP
cord-332422-s15o0hie	138	29	CD81	CD81	NNP
cord-332422-s15o0hie	138	30	is	be	VBZ
cord-332422-s15o0hie	138	31	not	not	RB
cord-332422-s15o0hie	138	32	preferentially	preferentially	RB
cord-332422-s15o0hie	138	33	used	use	VBN
cord-332422-s15o0hie	138	34	by	by	IN
cord-332422-s15o0hie	138	35	HCV	HCV	NNP
cord-332422-s15o0hie	138	36	for	for	IN
cord-332422-s15o0hie	138	37	its	-PRON-	PRP$
cord-332422-s15o0hie	138	38	entry	entry	NN
cord-332422-s15o0hie	138	39	[	[	-LRB-
cord-332422-s15o0hie	138	40	40	40	CD
cord-332422-s15o0hie	138	41	]	]	-RRB-
cord-332422-s15o0hie	138	42	.	.	.
cord-332422-s15o0hie	139	1	HCV	HCV	NNP
cord-332422-s15o0hie	139	2	entry	entry	NN
cord-332422-s15o0hie	139	3	is	be	VBZ
cord-332422-s15o0hie	139	4	a	a	DT
cord-332422-s15o0hie	139	5	multisequential	multisequential	JJ
cord-332422-s15o0hie	139	6	process	process	NN
cord-332422-s15o0hie	139	7	that	that	WDT
cord-332422-s15o0hie	139	8	is	be	VBZ
cord-332422-s15o0hie	139	9	highly	highly	RB
cord-332422-s15o0hie	139	10	dynamic	dynamic	JJ
cord-332422-s15o0hie	139	11	.	.	.
cord-332422-s15o0hie	140	1	CD81	CD81	NNP
cord-332422-s15o0hie	140	2	association	association	NN
cord-332422-s15o0hie	140	3	with	with	IN
cord-332422-s15o0hie	140	4	TEM	TEM	NNP
cord-332422-s15o0hie	140	5	may	may	MD
cord-332422-s15o0hie	140	6	lead	lead	VB
cord-332422-s15o0hie	140	7	to	to	IN
cord-332422-s15o0hie	140	8	the	the	DT
cord-332422-s15o0hie	140	9	sequestration	sequestration	NN
cord-332422-s15o0hie	140	10	of	of	IN
cord-332422-s15o0hie	140	11	this	this	DT
cord-332422-s15o0hie	140	12	tetraspanin	tetraspanin	NN
cord-332422-s15o0hie	140	13	which	which	WDT
cord-332422-s15o0hie	140	14	might	may	MD
cord-332422-s15o0hie	140	15	impede	impede	VB
cord-332422-s15o0hie	140	16	its	-PRON-	PRP$
cord-332422-s15o0hie	140	17	interaction	interaction	NN
cord-332422-s15o0hie	140	18	with	with	IN
cord-332422-s15o0hie	140	19	other	other	JJ
cord-332422-s15o0hie	140	20	coreceptors	coreceptor	NNS
cord-332422-s15o0hie	140	21	that	that	WDT
cord-332422-s15o0hie	140	22	are	be	VBP
cord-332422-s15o0hie	140	23	necessary	necessary	JJ
cord-332422-s15o0hie	140	24	for	for	IN
cord-332422-s15o0hie	140	25	efficient	efficient	JJ
cord-332422-s15o0hie	140	26	HCV	HCV	NNP
cord-332422-s15o0hie	140	27	entry	entry	NN
cord-332422-s15o0hie	140	28	.	.	.
cord-332422-s15o0hie	141	1	Alternatively	alternatively	RB
cord-332422-s15o0hie	141	2	,	,	,
cord-332422-s15o0hie	141	3	tetraspanins	tetraspanin	NNS
cord-332422-s15o0hie	141	4	may	may	MD
cord-332422-s15o0hie	141	5	compete	compete	VB
cord-332422-s15o0hie	141	6	with	with	IN
cord-332422-s15o0hie	141	7	coreceptors	coreceptor	NNS
cord-332422-s15o0hie	141	8	for	for	IN
cord-332422-s15o0hie	141	9	their	-PRON-	PRP$
cord-332422-s15o0hie	141	10	interaction	interaction	NN
cord-332422-s15o0hie	141	11	with	with	IN
cord-332422-s15o0hie	141	12	CD81	CD81	NNP
cord-332422-s15o0hie	141	13	.	.	.
cord-332422-s15o0hie	142	1	In	in	IN
cord-332422-s15o0hie	142	2	addition	addition	NN
cord-332422-s15o0hie	142	3	,	,	,
cord-332422-s15o0hie	142	4	the	the	DT
cord-332422-s15o0hie	142	5	lipid	lipid	NN
cord-332422-s15o0hie	142	6	composition	composition	NN
cord-332422-s15o0hie	142	7	of	of	IN
cord-332422-s15o0hie	142	8	TEMs	TEMs	NNPS
cord-332422-s15o0hie	142	9	might	may	MD
cord-332422-s15o0hie	142	10	not	not	RB
cord-332422-s15o0hie	142	11	be	be	VB
cord-332422-s15o0hie	142	12	suitable	suitable	JJ
cord-332422-s15o0hie	142	13	for	for	IN
cord-332422-s15o0hie	142	14	HCV	HCV	NNP
cord-332422-s15o0hie	142	15	entry	entry	NN
cord-332422-s15o0hie	142	16	.	.	.
cord-332422-s15o0hie	143	1	A	a	DT
cord-332422-s15o0hie	143	2	study	study	NN
cord-332422-s15o0hie	143	3	of	of	IN
cord-332422-s15o0hie	143	4	CD81-associated	CD81-associated	NNP
cord-332422-s15o0hie	143	5	proteins	protein	NNS
cord-332422-s15o0hie	143	6	led	lead	VBD
cord-332422-s15o0hie	143	7	to	to	IN
cord-332422-s15o0hie	143	8	the	the	DT
cord-332422-s15o0hie	143	9	identification	identification	NN
cord-332422-s15o0hie	143	10	of	of	IN
cord-332422-s15o0hie	143	11	EWI-2wint	EWI-2wint	NNP
cord-332422-s15o0hie	143	12	,	,	,
cord-332422-s15o0hie	143	13	a	a	DT
cord-332422-s15o0hie	143	14	partner	partner	NN
cord-332422-s15o0hie	143	15	of	of	IN
cord-332422-s15o0hie	143	16	CD81	CD81	NNP
cord-332422-s15o0hie	143	17	that	that	WDT
cord-332422-s15o0hie	143	18	blocks	block	VBZ
cord-332422-s15o0hie	143	19	E2	e2	NN
cord-332422-s15o0hie	143	20	binding	bind	VBG
cord-332422-s15o0hie	143	21	to	to	IN
cord-332422-s15o0hie	143	22	CD81	CD81	NNP
cord-332422-s15o0hie	143	23	[	[	-LRB-
cord-332422-s15o0hie	143	24	42	42	CD
cord-332422-s15o0hie	143	25	]	]	-RRB-
cord-332422-s15o0hie	143	26	.	.	.
cord-332422-s15o0hie	144	1	EWI-2wint	EWI-2wint	NNP
cord-332422-s15o0hie	144	2	is	be	VBZ
cord-332422-s15o0hie	144	3	a	a	DT
cord-332422-s15o0hie	144	4	natural	natural	JJ
cord-332422-s15o0hie	144	5	inhibitor	inhibitor	NN
cord-332422-s15o0hie	144	6	that	that	WDT
cord-332422-s15o0hie	144	7	is	be	VBZ
cord-332422-s15o0hie	144	8	produced	produce	VBN
cord-332422-s15o0hie	144	9	following	follow	VBG
cord-332422-s15o0hie	144	10	the	the	DT
cord-332422-s15o0hie	144	11	cleavage	cleavage	NN
cord-332422-s15o0hie	144	12	of	of	IN
cord-332422-s15o0hie	144	13	EWI-2	EWI-2	NNP
cord-332422-s15o0hie	144	14	,	,	,
cord-332422-s15o0hie	144	15	a	a	DT
cord-332422-s15o0hie	144	16	major	major	JJ
cord-332422-s15o0hie	144	17	partner	partner	NN
cord-332422-s15o0hie	144	18	of	of	IN
cord-332422-s15o0hie	144	19	CD81	CD81	NNP
cord-332422-s15o0hie	144	20	that	that	WDT
cord-332422-s15o0hie	144	21	is	be	VBZ
cord-332422-s15o0hie	144	22	expressed	express	VBN
cord-332422-s15o0hie	144	23	in	in	IN
cord-332422-s15o0hie	144	24	most	most	JJS
cord-332422-s15o0hie	144	25	cells	cell	NNS
cord-332422-s15o0hie	144	26	.	.	.
cord-332422-s15o0hie	145	1	EWI-2wint	EWI-2wint	NNP
cord-332422-s15o0hie	145	2	is	be	VBZ
cord-332422-s15o0hie	145	3	notably	notably	RB
cord-332422-s15o0hie	145	4	absent	absent	JJ
cord-332422-s15o0hie	145	5	in	in	IN
cord-332422-s15o0hie	145	6	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	145	7	,	,	,
cord-332422-s15o0hie	145	8	enabling	enable	VBG
cord-332422-s15o0hie	145	9	the	the	DT
cord-332422-s15o0hie	145	10	binding	binding	NN
cord-332422-s15o0hie	145	11	of	of	IN
cord-332422-s15o0hie	145	12	E2	E2	NNP
cord-332422-s15o0hie	145	13	to	to	IN
cord-332422-s15o0hie	145	14	CD81	CD81	NNP
cord-332422-s15o0hie	145	15	and	and	CC
cord-332422-s15o0hie	145	16	allowing	allow	VBG
cord-332422-s15o0hie	145	17	subsequent	subsequent	JJ
cord-332422-s15o0hie	145	18	infection	infection	NN
cord-332422-s15o0hie	145	19	.	.	.
cord-332422-s15o0hie	146	1	In	in	IN
cord-332422-s15o0hie	146	2	addition	addition	NN
cord-332422-s15o0hie	146	3	to	to	IN
cord-332422-s15o0hie	146	4	the	the	DT
cord-332422-s15o0hie	146	5	presence	presence	NN
cord-332422-s15o0hie	146	6	of	of	IN
cord-332422-s15o0hie	146	7	specific	specific	JJ
cord-332422-s15o0hie	146	8	entry	entry	NN
cord-332422-s15o0hie	146	9	factors	factor	NNS
cord-332422-s15o0hie	146	10	,	,	,
cord-332422-s15o0hie	146	11	hepatotropism	hepatotropism	NN
cord-332422-s15o0hie	146	12	might	may	MD
cord-332422-s15o0hie	146	13	be	be	VB
cord-332422-s15o0hie	146	14	partly	partly	RB
cord-332422-s15o0hie	146	15	due	due	JJ
cord-332422-s15o0hie	146	16	to	to	IN
cord-332422-s15o0hie	146	17	the	the	DT
cord-332422-s15o0hie	146	18	absence	absence	NN
cord-332422-s15o0hie	146	19	of	of	IN
cord-332422-s15o0hie	146	20	EWI-2wint	EWI-2wint	NNP
cord-332422-s15o0hie	146	21	.	.	.
cord-332422-s15o0hie	147	1	The	the	DT
cord-332422-s15o0hie	147	2	regions	region	NNS
cord-332422-s15o0hie	147	3	involved	involve	VBN
cord-332422-s15o0hie	147	4	in	in	IN
cord-332422-s15o0hie	147	5	the	the	DT
cord-332422-s15o0hie	147	6	interaction	interaction	NN
cord-332422-s15o0hie	147	7	between	between	IN
cord-332422-s15o0hie	147	8	EWI-2	ewi-2	NN
cord-332422-s15o0hie	147	9	/	/	SYM
cord-332422-s15o0hie	147	10	EWI-2wint	ewi-2wint	NN
cord-332422-s15o0hie	147	11	and	and	CC
cord-332422-s15o0hie	147	12	CD81	CD81	NNP
cord-332422-s15o0hie	147	13	have	have	VBP
cord-332422-s15o0hie	147	14	recently	recently	RB
cord-332422-s15o0hie	147	15	been	be	VBN
cord-332422-s15o0hie	147	16	identified	identify	VBN
cord-332422-s15o0hie	147	17	,	,	,
cord-332422-s15o0hie	147	18	and	and	CC
cord-332422-s15o0hie	147	19	it	-PRON-	PRP
cord-332422-s15o0hie	147	20	has	have	VBZ
cord-332422-s15o0hie	147	21	been	be	VBN
cord-332422-s15o0hie	147	22	shown	show	VBN
cord-332422-s15o0hie	147	23	that	that	IN
cord-332422-s15o0hie	147	24	EWI-2wint	ewi-2wint	JJ
cord-332422-s15o0hie	147	25	mutants	mutant	NNS
cord-332422-s15o0hie	147	26	,	,	,
cord-332422-s15o0hie	147	27	which	which	WDT
cord-332422-s15o0hie	147	28	no	no	RB
cord-332422-s15o0hie	147	29	longer	longer	RB
cord-332422-s15o0hie	147	30	interact	interact	VBP
cord-332422-s15o0hie	147	31	with	with	IN
cord-332422-s15o0hie	147	32	CD81	CD81	NNP
cord-332422-s15o0hie	147	33	,	,	,
cord-332422-s15o0hie	147	34	are	be	VBP
cord-332422-s15o0hie	147	35	not	not	RB
cord-332422-s15o0hie	147	36	able	able	JJ
cord-332422-s15o0hie	147	37	to	to	TO
cord-332422-s15o0hie	147	38	exert	exert	VB
cord-332422-s15o0hie	147	39	their	-PRON-	PRP$
cord-332422-s15o0hie	147	40	inhibitory	inhibitory	JJ
cord-332422-s15o0hie	147	41	effect	effect	NN
cord-332422-s15o0hie	147	42	on	on	IN
cord-332422-s15o0hie	147	43	HCV	HCV	NNP
cord-332422-s15o0hie	147	44	infection	infection	NN
cord-332422-s15o0hie	147	45	[	[	-LRB-
cord-332422-s15o0hie	147	46	43	43	CD
cord-332422-s15o0hie	147	47	]	]	-RRB-
cord-332422-s15o0hie	147	48	.	.	.
cord-332422-s15o0hie	148	1	Tight	tight	JJ
cord-332422-s15o0hie	148	2	junctions	junction	NNS
cord-332422-s15o0hie	148	3	(	(	-LRB-
cord-332422-s15o0hie	148	4	TJs	tj	NNS
cord-332422-s15o0hie	148	5	)	)	-RRB-
cord-332422-s15o0hie	148	6	are	be	VBP
cord-332422-s15o0hie	148	7	membrane	membrane	NN
cord-332422-s15o0hie	148	8	components	component	NNS
cord-332422-s15o0hie	148	9	specialized	specialize	VBN
cord-332422-s15o0hie	148	10	in	in	IN
cord-332422-s15o0hie	148	11	sealing	seal	VBG
cord-332422-s15o0hie	148	12	cells	cell	NNS
cord-332422-s15o0hie	148	13	.	.	.
cord-332422-s15o0hie	149	1	They	-PRON-	PRP
cord-332422-s15o0hie	149	2	have	have	VBP
cord-332422-s15o0hie	149	3	the	the	DT
cord-332422-s15o0hie	149	4	double	double	JJ
cord-332422-s15o0hie	149	5	function	function	NN
cord-332422-s15o0hie	149	6	of	of	IN
cord-332422-s15o0hie	149	7	controlling	control	VBG
cord-332422-s15o0hie	149	8	paracellular	paracellular	NNP
cord-332422-s15o0hie	149	9	diffusion	diffusion	NNP
cord-332422-s15o0hie	149	10	(	(	-LRB-
cord-332422-s15o0hie	149	11	barrier	barrier	NN
cord-332422-s15o0hie	149	12	function	function	NN
cord-332422-s15o0hie	149	13	)	)	-RRB-
cord-332422-s15o0hie	149	14	and	and	CC
cord-332422-s15o0hie	149	15	restricting	restrict	VBG
cord-332422-s15o0hie	149	16	the	the	DT
cord-332422-s15o0hie	149	17	diffusion	diffusion	NN
cord-332422-s15o0hie	149	18	of	of	IN
cord-332422-s15o0hie	149	19	membrane	membrane	NN
cord-332422-s15o0hie	149	20	proteins	protein	NNS
cord-332422-s15o0hie	149	21	and	and	CC
cord-332422-s15o0hie	149	22	lipids	lipid	NNS
cord-332422-s15o0hie	149	23	of	of	IN
cord-332422-s15o0hie	149	24	the	the	DT
cord-332422-s15o0hie	149	25	pole	pole	NN
cord-332422-s15o0hie	149	26	(	(	-LRB-
cord-332422-s15o0hie	149	27	fence	fence	NN
cord-332422-s15o0hie	149	28	function	function	NN
cord-332422-s15o0hie	149	29	)	)	-RRB-
cord-332422-s15o0hie	149	30	[	[	-LRB-
cord-332422-s15o0hie	149	31	44	44	CD
cord-332422-s15o0hie	149	32	]	]	-RRB-
cord-332422-s15o0hie	149	33	.	.	.
cord-332422-s15o0hie	150	1	In	in	IN
cord-332422-s15o0hie	150	2	electron	electron	NN
cord-332422-s15o0hie	150	3	microscopy	microscopy	NNS
cord-332422-s15o0hie	150	4	,	,	,
cord-332422-s15o0hie	150	5	TJs	tjs	FW
cord-332422-s15o0hie	150	6	form	form	VBP
cord-332422-s15o0hie	150	7	a	a	DT
cord-332422-s15o0hie	150	8	dense	dense	JJ
cord-332422-s15o0hie	150	9	structure	structure	NN
cord-332422-s15o0hie	150	10	characterized	characterize	VBN
cord-332422-s15o0hie	150	11	by	by	IN
cord-332422-s15o0hie	150	12	a	a	DT
cord-332422-s15o0hie	150	13	close	close	JJ
cord-332422-s15o0hie	150	14	apposition	apposition	NN
cord-332422-s15o0hie	150	15	of	of	IN
cord-332422-s15o0hie	150	16	membranes	membrane	NNS
cord-332422-s15o0hie	150	17	of	of	IN
cord-332422-s15o0hie	150	18	neighboring	neighboring	NN
cord-332422-s15o0hie	150	19	cells	cell	NNS
cord-332422-s15o0hie	150	20	and	and	CC
cord-332422-s15o0hie	150	21	a	a	DT
cord-332422-s15o0hie	150	22	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	150	23	plaque	plaque	NN
cord-332422-s15o0hie	150	24	.	.	.
cord-332422-s15o0hie	151	1	Indeed	indeed	RB
cord-332422-s15o0hie	151	2	,	,	,
cord-332422-s15o0hie	151	3	these	these	DT
cord-332422-s15o0hie	151	4	structures	structure	NNS
cord-332422-s15o0hie	151	5	are	be	VBP
cord-332422-s15o0hie	151	6	composed	compose	VBN
cord-332422-s15o0hie	151	7	of	of	IN
cord-332422-s15o0hie	151	8	transmembrane	transmembrane	NN
cord-332422-s15o0hie	151	9	proteins	protein	NNS
cord-332422-s15o0hie	151	10	and	and	CC
cord-332422-s15o0hie	151	11	intracellular	intracellular	JJ
cord-332422-s15o0hie	151	12	molecules	molecule	NNS
cord-332422-s15o0hie	151	13	.	.	.
cord-332422-s15o0hie	152	1	Transmembrane	Transmembrane	NNP
cord-332422-s15o0hie	152	2	proteins	protein	NNS
cord-332422-s15o0hie	152	3	play	play	VBP
cord-332422-s15o0hie	152	4	an	an	DT
cord-332422-s15o0hie	152	5	important	important	JJ
cord-332422-s15o0hie	152	6	role	role	NN
cord-332422-s15o0hie	152	7	in	in	IN
cord-332422-s15o0hie	152	8	sealing	seal	VBG
cord-332422-s15o0hie	152	9	the	the	DT
cord-332422-s15o0hie	152	10	cells	cell	NNS
cord-332422-s15o0hie	152	11	by	by	IN
cord-332422-s15o0hie	152	12	interacting	interact	VBG
cord-332422-s15o0hie	152	13	with	with	IN
cord-332422-s15o0hie	152	14	similar	similar	JJ
cord-332422-s15o0hie	152	15	molecules	molecule	NNS
cord-332422-s15o0hie	152	16	either	either	CC
cord-332422-s15o0hie	152	17	in	in	IN
cord-332422-s15o0hie	152	18	cis	cis	NNP
cord-332422-s15o0hie	152	19	(	(	-LRB-
cord-332422-s15o0hie	152	20	on	on	IN
cord-332422-s15o0hie	152	21	the	the	DT
cord-332422-s15o0hie	152	22	membrane	membrane	NN
cord-332422-s15o0hie	152	23	of	of	IN
cord-332422-s15o0hie	152	24	the	the	DT
cord-332422-s15o0hie	152	25	same	same	JJ
cord-332422-s15o0hie	152	26	cell	cell	NN
cord-332422-s15o0hie	152	27	)	)	-RRB-
cord-332422-s15o0hie	152	28	or	or	CC
cord-332422-s15o0hie	152	29	in	in	IN
cord-332422-s15o0hie	152	30	trans	trans	NNP
cord-332422-s15o0hie	152	31	(	(	-LRB-
cord-332422-s15o0hie	152	32	on	on	IN
cord-332422-s15o0hie	152	33	the	the	DT
cord-332422-s15o0hie	152	34	membrane	membrane	NN
cord-332422-s15o0hie	152	35	of	of	IN
cord-332422-s15o0hie	152	36	facing	face	VBG
cord-332422-s15o0hie	152	37	cells	cell	NNS
cord-332422-s15o0hie	152	38	)	)	-RRB-
cord-332422-s15o0hie	152	39	.	.	.
cord-332422-s15o0hie	153	1	TJ	TJ	NNP
cord-332422-s15o0hie	153	2	functionality	functionality	NN
cord-332422-s15o0hie	153	3	and	and	CC
cord-332422-s15o0hie	153	4	architecture	architecture	NN
cord-332422-s15o0hie	153	5	are	be	VBP
cord-332422-s15o0hie	153	6	regulated	regulate	VBN
cord-332422-s15o0hie	153	7	by	by	IN
cord-332422-s15o0hie	153	8	signaling	signal	VBG
cord-332422-s15o0hie	153	9	pathways	pathway	NNS
cord-332422-s15o0hie	153	10	that	that	WDT
cord-332422-s15o0hie	153	11	rely	rely	VBP
cord-332422-s15o0hie	153	12	on	on	IN
cord-332422-s15o0hie	153	13	the	the	DT
cord-332422-s15o0hie	153	14	TJ	TJ	NNP
cord-332422-s15o0hie	153	15	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	153	16	plaque	plaque	NN
cord-332422-s15o0hie	153	17	.	.	.
cord-332422-s15o0hie	154	1	Transmembrane	Transmembrane	NNP
cord-332422-s15o0hie	154	2	proteins	protein	NNS
cord-332422-s15o0hie	154	3	interact	interact	VBP
cord-332422-s15o0hie	154	4	with	with	IN
cord-332422-s15o0hie	154	5	adapters	adapter	NNS
cord-332422-s15o0hie	154	6	of	of	IN
cord-332422-s15o0hie	154	7	the	the	DT
cord-332422-s15o0hie	154	8	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	154	9	plaque	plaque	NN
cord-332422-s15o0hie	154	10	that	that	WDT
cord-332422-s15o0hie	154	11	links	link	VBZ
cord-332422-s15o0hie	154	12	the	the	DT
cord-332422-s15o0hie	154	13	surface	surface	NN
cord-332422-s15o0hie	154	14	proteins	protein	NNS
cord-332422-s15o0hie	154	15	to	to	IN
cord-332422-s15o0hie	154	16	the	the	DT
cord-332422-s15o0hie	154	17	actin	actin	NN
cord-332422-s15o0hie	154	18	cytoskeleton	cytoskeleton	NN
cord-332422-s15o0hie	154	19	[	[	-LRB-
cord-332422-s15o0hie	154	20	44	44	CD
cord-332422-s15o0hie	154	21	]	]	-RRB-
cord-332422-s15o0hie	154	22	.	.	.
cord-332422-s15o0hie	155	1	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	155	2	and	and	CC
cord-332422-s15o0hie	155	3	OCLN	OCLN	NNP
cord-332422-s15o0hie	155	4	are	be	VBP
cord-332422-s15o0hie	155	5	two	two	CD
cord-332422-s15o0hie	155	6	transmembrane	transmembrane	NN
cord-332422-s15o0hie	155	7	components	component	NNS
cord-332422-s15o0hie	155	8	of	of	IN
cord-332422-s15o0hie	155	9	the	the	DT
cord-332422-s15o0hie	155	10	TJs	TJs	NNP
cord-332422-s15o0hie	155	11	.	.	.
cord-332422-s15o0hie	156	1	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	156	2	is	be	VBZ
cord-332422-s15o0hie	156	3	one	one	CD
cord-332422-s15o0hie	156	4	of	of	IN
cord-332422-s15o0hie	156	5	the	the	DT
cord-332422-s15o0hie	156	6	twenty	twenty	CD
cord-332422-s15o0hie	156	7	four	four	CD
cord-332422-s15o0hie	156	8	members	member	NNS
cord-332422-s15o0hie	156	9	of	of	IN
cord-332422-s15o0hie	156	10	the	the	DT
cord-332422-s15o0hie	156	11	CLDN	CLDN	NNP
cord-332422-s15o0hie	156	12	family	family	NN
cord-332422-s15o0hie	156	13	[	[	-LRB-
cord-332422-s15o0hie	156	14	45	45	CD
cord-332422-s15o0hie	156	15	]	]	-RRB-
cord-332422-s15o0hie	156	16	and	and	CC
cord-332422-s15o0hie	156	17	evidence	evidence	NN
cord-332422-s15o0hie	156	18	suggests	suggest	VBZ
cord-332422-s15o0hie	156	19	that	that	IN
cord-332422-s15o0hie	156	20	CLDNs	cldn	NNS
cord-332422-s15o0hie	156	21	constitute	constitute	VBP
cord-332422-s15o0hie	156	22	the	the	DT
cord-332422-s15o0hie	156	23	backbone	backbone	NN
cord-332422-s15o0hie	156	24	of	of	IN
cord-332422-s15o0hie	156	25	tight	tight	JJ
cord-332422-s15o0hie	156	26	junctions	junction	NNS
cord-332422-s15o0hie	156	27	.	.	.
cord-332422-s15o0hie	157	1	These	these	DT
cord-332422-s15o0hie	157	2	proteins	protein	NNS
cord-332422-s15o0hie	157	3	consist	consist	VBP
cord-332422-s15o0hie	157	4	of	of	IN
cord-332422-s15o0hie	157	5	four	four	CD
cord-332422-s15o0hie	157	6	transmembrane	transmembrane	NN
cord-332422-s15o0hie	157	7	domains	domain	NNS
cord-332422-s15o0hie	157	8	,	,	,
cord-332422-s15o0hie	157	9	two	two	CD
cord-332422-s15o0hie	157	10	extracellular	extracellular	JJ
cord-332422-s15o0hie	157	11	loops	loop	NNS
cord-332422-s15o0hie	157	12	and	and	CC
cord-332422-s15o0hie	157	13	two	two	CD
cord-332422-s15o0hie	157	14	cytosolic	cytosolic	JJ
cord-332422-s15o0hie	157	15	domains	domain	NNS
cord-332422-s15o0hie	157	16	.	.	.
cord-332422-s15o0hie	158	1	The	the	DT
cord-332422-s15o0hie	158	2	C	C	NNP
cord-332422-s15o0hie	158	3	-	-	HYPH
cord-332422-s15o0hie	158	4	terminus	terminus	NN
cord-332422-s15o0hie	158	5	contains	contain	VBZ
cord-332422-s15o0hie	158	6	a	a	DT
cord-332422-s15o0hie	158	7	PDZ	pdz	NN
cord-332422-s15o0hie	158	8	-	-	HYPH
cord-332422-s15o0hie	158	9	binding	bind	VBG
cord-332422-s15o0hie	158	10	motif	motif	NN
cord-332422-s15o0hie	158	11	which	which	WDT
cord-332422-s15o0hie	158	12	binds	bind	VBZ
cord-332422-s15o0hie	158	13	to	to	IN
cord-332422-s15o0hie	158	14	PDZ	PDZ	NNP
cord-332422-s15o0hie	158	15	-	-	HYPH
cord-332422-s15o0hie	158	16	containing	contain	VBG
cord-332422-s15o0hie	158	17	plaque	plaque	NN
cord-332422-s15o0hie	158	18	proteins	protein	NNS
cord-332422-s15o0hie	158	19	such	such	JJ
cord-332422-s15o0hie	158	20	as	as	IN
cord-332422-s15o0hie	158	21	the	the	DT
cord-332422-s15o0hie	158	22	Zonula	Zonula	NNP
cord-332422-s15o0hie	158	23	Occludens	Occludens	NNP
cord-332422-s15o0hie	158	24	(	(	-LRB-
cord-332422-s15o0hie	158	25	ZO	ZO	NNP
cord-332422-s15o0hie	158	26	)	)	-RRB-
cord-332422-s15o0hie	158	27	proteins	protein	NNS
cord-332422-s15o0hie	158	28	(	(	-LRB-
cord-332422-s15o0hie	158	29	Figure	figure	NN
cord-332422-s15o0hie	158	30	2	2	CD
cord-332422-s15o0hie	158	31	)	)	-RRB-
cord-332422-s15o0hie	158	32	.	.	.
cord-332422-s15o0hie	159	1	The	the	DT
cord-332422-s15o0hie	159	2	first	first	JJ
cord-332422-s15o0hie	159	3	extracellular	extracellular	JJ
cord-332422-s15o0hie	159	4	loop	loop	NN
cord-332422-s15o0hie	159	5	(	(	-LRB-
cord-332422-s15o0hie	159	6	EC1	EC1	NNP
cord-332422-s15o0hie	159	7	)	)	-RRB-
cord-332422-s15o0hie	159	8	contains	contain	VBZ
cord-332422-s15o0hie	159	9	a	a	DT
cord-332422-s15o0hie	159	10	conserved	conserved	JJ
cord-332422-s15o0hie	159	11	GLWxxC(8	glwxxc(8	NN
cord-332422-s15o0hie	159	12	-	-	HYPH
cord-332422-s15o0hie	159	13	10aa)C	10aa)c	CD
cord-332422-s15o0hie	159	14	motif	motif	NN
cord-332422-s15o0hie	159	15	.	.	.
cord-332422-s15o0hie	160	1	OCLN	OCLN	NNP
cord-332422-s15o0hie	160	2	was	be	VBD
cord-332422-s15o0hie	160	3	the	the	DT
cord-332422-s15o0hie	160	4	first	first	JJ
cord-332422-s15o0hie	160	5	integral	integral	JJ
cord-332422-s15o0hie	160	6	TJ	TJ	NNP
cord-332422-s15o0hie	160	7	protein	protein	NN
cord-332422-s15o0hie	160	8	to	to	TO
cord-332422-s15o0hie	160	9	be	be	VB
cord-332422-s15o0hie	160	10	identified	identify	VBN
cord-332422-s15o0hie	160	11	and	and	CC
cord-332422-s15o0hie	160	12	is	be	VBZ
cord-332422-s15o0hie	160	13	a	a	DT
cord-332422-s15o0hie	160	14	protein	protein	NN
cord-332422-s15o0hie	160	15	composed	compose	VBN
cord-332422-s15o0hie	160	16	of	of	IN
cord-332422-s15o0hie	160	17	four	four	CD
cord-332422-s15o0hie	160	18	transmembrane	transmembrane	NN
cord-332422-s15o0hie	160	19	domains	domain	NNS
cord-332422-s15o0hie	160	20	,	,	,
cord-332422-s15o0hie	160	21	two	two	CD
cord-332422-s15o0hie	160	22	extracellular	extracellular	JJ
cord-332422-s15o0hie	160	23	loops	loop	NNS
cord-332422-s15o0hie	160	24	,	,	,
cord-332422-s15o0hie	160	25	a	a	DT
cord-332422-s15o0hie	160	26	short	short	JJ
cord-332422-s15o0hie	160	27	N	n	CD
cord-332422-s15o0hie	160	28	-	-	HYPH
cord-332422-s15o0hie	160	29	terminal	terminal	JJ
cord-332422-s15o0hie	160	30	cytoplasmic	cytoplasmic	JJ
cord-332422-s15o0hie	160	31	domain	domain	NN
cord-332422-s15o0hie	160	32	and	and	CC
cord-332422-s15o0hie	160	33	a	a	DT
cord-332422-s15o0hie	160	34	long	long	JJ
cord-332422-s15o0hie	160	35	C	c	NN
cord-332422-s15o0hie	160	36	-	-	HYPH
cord-332422-s15o0hie	160	37	terminal	terminal	NN
cord-332422-s15o0hie	160	38	one	one	CD
cord-332422-s15o0hie	160	39	(	(	-LRB-
cord-332422-s15o0hie	160	40	Figure	figure	NN
cord-332422-s15o0hie	160	41	2	2	CD
cord-332422-s15o0hie	160	42	)	)	-RRB-
cord-332422-s15o0hie	160	43	.	.	.
cord-332422-s15o0hie	161	1	The	the	DT
cord-332422-s15o0hie	161	2	first	first	JJ
cord-332422-s15o0hie	161	3	extracellular	extracellular	JJ
cord-332422-s15o0hie	161	4	loop	loop	NN
cord-332422-s15o0hie	161	5	is	be	VBZ
cord-332422-s15o0hie	161	6	rich	rich	JJ
cord-332422-s15o0hie	161	7	(	(	-LRB-
cord-332422-s15o0hie	161	8	~60	~60	CD
cord-332422-s15o0hie	161	9	%	%	NN
cord-332422-s15o0hie	161	10	)	)	-RRB-
cord-332422-s15o0hie	161	11	in	in	IN
cord-332422-s15o0hie	161	12	glycine	glycine	NN
cord-332422-s15o0hie	161	13	and	and	CC
cord-332422-s15o0hie	161	14	tyrosine	tyrosine	NN
cord-332422-s15o0hie	161	15	residues	residue	NNS
cord-332422-s15o0hie	161	16	.	.	.
cord-332422-s15o0hie	162	1	The	the	DT
cord-332422-s15o0hie	162	2	function	function	NN
cord-332422-s15o0hie	162	3	of	of	IN
cord-332422-s15o0hie	162	4	OCLN	OCLN	NNP
cord-332422-s15o0hie	162	5	is	be	VBZ
cord-332422-s15o0hie	162	6	not	not	RB
cord-332422-s15o0hie	162	7	well	well	RB
cord-332422-s15o0hie	162	8	understood	understand	VBN
cord-332422-s15o0hie	163	1	but	but	CC
cord-332422-s15o0hie	163	2	it	-PRON-	PRP
cord-332422-s15o0hie	163	3	may	may	MD
cord-332422-s15o0hie	163	4	participate	participate	VB
cord-332422-s15o0hie	163	5	in	in	IN
cord-332422-s15o0hie	163	6	the	the	DT
cord-332422-s15o0hie	163	7	assembly	assembly	NN
cord-332422-s15o0hie	163	8	and	and	CC
cord-332422-s15o0hie	163	9	barrier	barrier	NN
cord-332422-s15o0hie	163	10	function	function	NN
cord-332422-s15o0hie	163	11	of	of	IN
cord-332422-s15o0hie	163	12	TJs	tj	NNS
cord-332422-s15o0hie	163	13	[	[	-LRB-
cord-332422-s15o0hie	163	14	45	45	CD
cord-332422-s15o0hie	163	15	]	]	-RRB-
cord-332422-s15o0hie	163	16	.	.	.
cord-332422-s15o0hie	164	1	Recently	recently	RB
cord-332422-s15o0hie	164	2	,	,	,
cord-332422-s15o0hie	164	3	CLDN1	cldn1	NN
cord-332422-s15o0hie	164	4	and	and	CC
cord-332422-s15o0hie	164	5	OCLN	OCLN	NNP
cord-332422-s15o0hie	164	6	have	have	VBP
cord-332422-s15o0hie	164	7	been	be	VBN
cord-332422-s15o0hie	164	8	identified	identify	VBN
cord-332422-s15o0hie	164	9	as	as	IN
cord-332422-s15o0hie	164	10	two	two	CD
cord-332422-s15o0hie	164	11	essential	essential	JJ
cord-332422-s15o0hie	164	12	entry	entry	NN
cord-332422-s15o0hie	164	13	factors	factor	NNS
cord-332422-s15o0hie	164	14	for	for	IN
cord-332422-s15o0hie	164	15	HCV	HCV	NNP
cord-332422-s15o0hie	164	16	[	[	-LRB-
cord-332422-s15o0hie	164	17	27	27	CD
cord-332422-s15o0hie	164	18	,	,	,
cord-332422-s15o0hie	164	19	46	46	CD
cord-332422-s15o0hie	164	20	,	,	,
cord-332422-s15o0hie	164	21	47	47	CD
cord-332422-s15o0hie	164	22	]	]	-RRB-
cord-332422-s15o0hie	164	23	.	.	.
cord-332422-s15o0hie	165	1	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	165	2	was	be	VBD
cord-332422-s15o0hie	165	3	the	the	DT
cord-332422-s15o0hie	165	4	first	first	JJ
cord-332422-s15o0hie	165	5	to	to	TO
cord-332422-s15o0hie	165	6	be	be	VB
cord-332422-s15o0hie	165	7	identified	identify	VBN
cord-332422-s15o0hie	165	8	in	in	IN
cord-332422-s15o0hie	165	9	a	a	DT
cord-332422-s15o0hie	165	10	complementary	complementary	JJ
cord-332422-s15o0hie	165	11	DNA	dna	NN
cord-332422-s15o0hie	165	12	library	library	NN
cord-332422-s15o0hie	165	13	screen	screen	NN
cord-332422-s15o0hie	165	14	for	for	IN
cord-332422-s15o0hie	165	15	genes	gene	NNS
cord-332422-s15o0hie	165	16	that	that	WDT
cord-332422-s15o0hie	165	17	confer	confer	VBP
cord-332422-s15o0hie	165	18	HCVpp	hcvpp	IN
cord-332422-s15o0hie	165	19	susceptibility	susceptibility	NN
cord-332422-s15o0hie	165	20	to	to	IN
cord-332422-s15o0hie	165	21	293	293	CD
cord-332422-s15o0hie	165	22	T	t	NN
cord-332422-s15o0hie	165	23	cells	cell	NNS
cord-332422-s15o0hie	165	24	[	[	-LRB-
cord-332422-s15o0hie	165	25	46	46	CD
cord-332422-s15o0hie	165	26	]	]	-RRB-
cord-332422-s15o0hie	165	27	.	.	.
cord-332422-s15o0hie	166	1	Antibodies	antibody	NNS
cord-332422-s15o0hie	166	2	directed	direct	VBN
cord-332422-s15o0hie	166	3	against	against	IN
cord-332422-s15o0hie	166	4	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	166	5	were	be	VBD
cord-332422-s15o0hie	166	6	also	also	RB
cord-332422-s15o0hie	166	7	shown	show	VBN
cord-332422-s15o0hie	166	8	to	to	TO
cord-332422-s15o0hie	166	9	inhibit	inhibit	VB
cord-332422-s15o0hie	166	10	HCV	HCV	NNP
cord-332422-s15o0hie	166	11	entry	entry	NN
cord-332422-s15o0hie	166	12	[	[	-LRB-
cord-332422-s15o0hie	166	13	48	48	CD
cord-332422-s15o0hie	166	14	]	]	-RRB-
cord-332422-s15o0hie	166	15	.	.	.
cord-332422-s15o0hie	167	1	Two	two	CD
cord-332422-s15o0hie	167	2	other	other	JJ
cord-332422-s15o0hie	167	3	members	member	NNS
cord-332422-s15o0hie	167	4	of	of	IN
cord-332422-s15o0hie	167	5	the	the	DT
cord-332422-s15o0hie	167	6	CLDN	CLDN	NNP
cord-332422-s15o0hie	167	7	family	family	NN
cord-332422-s15o0hie	167	8	,	,	,
cord-332422-s15o0hie	167	9	CLDN6	CLDN6	NNP
cord-332422-s15o0hie	167	10	and	and	CC
cord-332422-s15o0hie	167	11	CLDN9	CLDN9	NNP
cord-332422-s15o0hie	167	12	,	,	,
cord-332422-s15o0hie	167	13	are	be	VBP
cord-332422-s15o0hie	167	14	also	also	RB
cord-332422-s15o0hie	167	15	able	able	JJ
cord-332422-s15o0hie	167	16	to	to	TO
cord-332422-s15o0hie	167	17	render	render	VB
cord-332422-s15o0hie	167	18	293	293	CD
cord-332422-s15o0hie	167	19	T	t	NN
cord-332422-s15o0hie	167	20	cells	cell	NNS
cord-332422-s15o0hie	167	21	permissive	permissive	JJ
cord-332422-s15o0hie	167	22	for	for	IN
cord-332422-s15o0hie	167	23	HCV	HCV	NNP
cord-332422-s15o0hie	167	24	entry	entry	NN
cord-332422-s15o0hie	167	25	[	[	-LRB-
cord-332422-s15o0hie	167	26	49	49	CD
cord-332422-s15o0hie	167	27	,	,	,
cord-332422-s15o0hie	167	28	50	50	CD
cord-332422-s15o0hie	167	29	]	]	-RRB-
cord-332422-s15o0hie	167	30	.	.	.
cord-332422-s15o0hie	168	1	The	the	DT
cord-332422-s15o0hie	168	2	first	first	JJ
cord-332422-s15o0hie	168	3	extracellular	extracellular	JJ
cord-332422-s15o0hie	168	4	loop	loop	NN
cord-332422-s15o0hie	168	5	of	of	IN
cord-332422-s15o0hie	168	6	CLDN1	cldn1	NN
cord-332422-s15o0hie	168	7	has	have	VBZ
cord-332422-s15o0hie	168	8	been	be	VBN
cord-332422-s15o0hie	168	9	shown	show	VBN
cord-332422-s15o0hie	168	10	to	to	TO
cord-332422-s15o0hie	168	11	be	be	VB
cord-332422-s15o0hie	168	12	involved	involve	VBN
cord-332422-s15o0hie	168	13	in	in	IN
cord-332422-s15o0hie	168	14	HCV	HCV	NNP
cord-332422-s15o0hie	168	15	entry	entry	NN
cord-332422-s15o0hie	168	16	[	[	-LRB-
cord-332422-s15o0hie	168	17	46	46	CD
cord-332422-s15o0hie	168	18	,	,	,
cord-332422-s15o0hie	168	19	51	51	CD
cord-332422-s15o0hie	168	20	]	]	-RRB-
cord-332422-s15o0hie	168	21	,	,	,
cord-332422-s15o0hie	168	22	and	and	CC
cord-332422-s15o0hie	168	23	residues	residue	NNS
cord-332422-s15o0hie	168	24	important	important	JJ
cord-332422-s15o0hie	168	25	for	for	IN
cord-332422-s15o0hie	168	26	HCV	HCV	NNP
cord-332422-s15o0hie	168	27	infection	infection	NN
cord-332422-s15o0hie	168	28	have	have	VBP
cord-332422-s15o0hie	168	29	been	be	VBN
cord-332422-s15o0hie	168	30	identified	identify	VBN
cord-332422-s15o0hie	168	31	in	in	IN
cord-332422-s15o0hie	168	32	this	this	DT
cord-332422-s15o0hie	168	33	domain	domain	NN
cord-332422-s15o0hie	168	34	(	(	-LRB-
cord-332422-s15o0hie	168	35	Figure	figure	NN
cord-332422-s15o0hie	168	36	2	2	CD
cord-332422-s15o0hie	168	37	)	)	-RRB-
cord-332422-s15o0hie	168	38	.	.	.
cord-332422-s15o0hie	169	1	Indeed	indeed	RB
cord-332422-s15o0hie	169	2	,	,	,
cord-332422-s15o0hie	169	3	mutations	mutation	NNS
cord-332422-s15o0hie	169	4	of	of	IN
cord-332422-s15o0hie	169	5	the	the	DT
cord-332422-s15o0hie	169	6	residues	residue	NNS
cord-332422-s15o0hie	169	7	I32	I32	NNP
cord-332422-s15o0hie	169	8	,	,	,
cord-332422-s15o0hie	169	9	D38	D38	NNP
cord-332422-s15o0hie	169	10	and	and	CC
cord-332422-s15o0hie	169	11	E48	E48	NNP
cord-332422-s15o0hie	169	12	as	as	RB
cord-332422-s15o0hie	169	13	well	well	RB
cord-332422-s15o0hie	169	14	as	as	IN
cord-332422-s15o0hie	169	15	in	in	IN
cord-332422-s15o0hie	169	16	the	the	DT
cord-332422-s15o0hie	169	17	GLWxxC(8	GLWxxC(8	NNP
cord-332422-s15o0hie	169	18	-	-	HYPH
cord-332422-s15o0hie	169	19	10aa)C	10aa)c	CD
cord-332422-s15o0hie	169	20	conserved	conserve	VBN
cord-332422-s15o0hie	169	21	motif	motif	NN
cord-332422-s15o0hie	169	22	affect	affect	VBP
cord-332422-s15o0hie	169	23	HCV	HCV	NNP
cord-332422-s15o0hie	169	24	entry	entry	NN
cord-332422-s15o0hie	169	25	[	[	-LRB-
cord-332422-s15o0hie	169	26	46	46	CD
cord-332422-s15o0hie	169	27	,	,	,
cord-332422-s15o0hie	169	28	51	51	CD
cord-332422-s15o0hie	169	29	]	]	-RRB-
cord-332422-s15o0hie	169	30	.	.	.
cord-332422-s15o0hie	170	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	170	2	,	,	,
cord-332422-s15o0hie	170	3	it	-PRON-	PRP
cord-332422-s15o0hie	170	4	has	have	VBZ
cord-332422-s15o0hie	170	5	been	be	VBN
cord-332422-s15o0hie	170	6	suggested	suggest	VBN
cord-332422-s15o0hie	170	7	that	that	IN
cord-332422-s15o0hie	170	8	the	the	DT
cord-332422-s15o0hie	170	9	second	second	JJ
cord-332422-s15o0hie	170	10	extracellular	extracellular	JJ
cord-332422-s15o0hie	170	11	loop	loop	NN
cord-332422-s15o0hie	170	12	may	may	MD
cord-332422-s15o0hie	170	13	also	also	RB
cord-332422-s15o0hie	170	14	modulate	modulate	VB
cord-332422-s15o0hie	170	15	CLDN1	cldn1	NN
cord-332422-s15o0hie	170	16	function	function	NN
cord-332422-s15o0hie	170	17	in	in	IN
cord-332422-s15o0hie	170	18	HCV	HCV	NNP
cord-332422-s15o0hie	170	19	entry	entry	NN
cord-332422-s15o0hie	170	20	.	.	.
cord-332422-s15o0hie	171	1	The	the	DT
cord-332422-s15o0hie	171	2	low	low	JJ
cord-332422-s15o0hie	171	3	efficacy	efficacy	NN
cord-332422-s15o0hie	171	4	of	of	IN
cord-332422-s15o0hie	171	5	mouse	mouse	NN
cord-332422-s15o0hie	171	6	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	171	7	in	in	IN
cord-332422-s15o0hie	171	8	mediating	mediate	VBG
cord-332422-s15o0hie	171	9	HCV	HCV	NNP
cord-332422-s15o0hie	171	10	infection	infection	NN
cord-332422-s15o0hie	171	11	is	be	VBZ
cord-332422-s15o0hie	171	12	linked	link	VBN
cord-332422-s15o0hie	171	13	to	to	IN
cord-332422-s15o0hie	171	14	three	three	CD
cord-332422-s15o0hie	171	15	amino	amino	NN
cord-332422-s15o0hie	171	16	acid	acid	NN
cord-332422-s15o0hie	171	17	residues	residue	NNS
cord-332422-s15o0hie	171	18	in	in	IN
cord-332422-s15o0hie	171	19	the	the	DT
cord-332422-s15o0hie	171	20	second	second	JJ
cord-332422-s15o0hie	171	21	extracellular	extracellular	JJ
cord-332422-s15o0hie	171	22	loop	loop	NN
cord-332422-s15o0hie	171	23	(	(	-LRB-
cord-332422-s15o0hie	171	24	L152	l152	FW
cord-332422-s15o0hie	171	25	,	,	,
cord-332422-s15o0hie	171	26	I155	I155	''
cord-332422-s15o0hie	171	27	)	)	-RRB-
cord-332422-s15o0hie	171	28	and	and	CC
cord-332422-s15o0hie	171	29	the	the	DT
cord-332422-s15o0hie	171	30	fourth	fourth	JJ
cord-332422-s15o0hie	171	31	transmembrane	transmembrane	NN
cord-332422-s15o0hie	171	32	helix	helix	NN
cord-332422-s15o0hie	171	33	(	(	-LRB-
cord-332422-s15o0hie	171	34	V180	V180	NNP
cord-332422-s15o0hie	171	35	)	)	-RRB-
cord-332422-s15o0hie	171	36	[	[	-LRB-
cord-332422-s15o0hie	171	37	52	52	CD
cord-332422-s15o0hie	171	38	]	]	-RRB-
cord-332422-s15o0hie	171	39	.	.	.
cord-332422-s15o0hie	172	1	In	in	IN
cord-332422-s15o0hie	172	2	contrast	contrast	NN
cord-332422-s15o0hie	172	3	,	,	,
cord-332422-s15o0hie	172	4	the	the	DT
cord-332422-s15o0hie	172	5	C	c	NN
cord-332422-s15o0hie	172	6	-	-	HYPH
cord-332422-s15o0hie	172	7	terminal	terminal	NN
cord-332422-s15o0hie	172	8	domain	domain	NN
cord-332422-s15o0hie	172	9	of	of	IN
cord-332422-s15o0hie	172	10	CLDN1	cldn1	NN
cord-332422-s15o0hie	172	11	is	be	VBZ
cord-332422-s15o0hie	172	12	dispensable	dispensable	JJ
cord-332422-s15o0hie	172	13	for	for	IN
cord-332422-s15o0hie	172	14	HCV	HCV	NNP
cord-332422-s15o0hie	172	15	entry	entry	NN
cord-332422-s15o0hie	172	16	[	[	-LRB-
cord-332422-s15o0hie	172	17	46	46	CD
cord-332422-s15o0hie	172	18	]	]	-RRB-
cord-332422-s15o0hie	172	19	.	.	.
cord-332422-s15o0hie	173	1	OCLN	OCLN	NNP
cord-332422-s15o0hie	173	2	was	be	VBD
cord-332422-s15o0hie	173	3	the	the	DT
cord-332422-s15o0hie	173	4	last	last	JJ
cord-332422-s15o0hie	173	5	entry	entry	NN
cord-332422-s15o0hie	173	6	factor	factor	NN
cord-332422-s15o0hie	173	7	to	to	TO
cord-332422-s15o0hie	173	8	be	be	VB
cord-332422-s15o0hie	173	9	identified	identify	VBN
cord-332422-s15o0hie	173	10	,	,	,
cord-332422-s15o0hie	173	11	and	and	CC
cord-332422-s15o0hie	173	12	is	be	VBZ
cord-332422-s15o0hie	173	13	probably	probably	RB
cord-332422-s15o0hie	173	14	involved	involve	VBN
cord-332422-s15o0hie	173	15	in	in	IN
cord-332422-s15o0hie	173	16	a	a	DT
cord-332422-s15o0hie	173	17	late	late	JJ
cord-332422-s15o0hie	173	18	post	post	JJ
cord-332422-s15o0hie	173	19	-	-	JJ
cord-332422-s15o0hie	173	20	binding	binding	JJ
cord-332422-s15o0hie	173	21	step	step	NN
cord-332422-s15o0hie	173	22	[	[	-LRB-
cord-332422-s15o0hie	173	23	47	47	CD
cord-332422-s15o0hie	173	24	,	,	,
cord-332422-s15o0hie	173	25	53	53	CD
cord-332422-s15o0hie	173	26	,	,	,
cord-332422-s15o0hie	173	27	54	54	CD
cord-332422-s15o0hie	173	28	]	]	-RRB-
cord-332422-s15o0hie	173	29	.	.	.
cord-332422-s15o0hie	174	1	By	by	IN
cord-332422-s15o0hie	174	2	using	use	VBG
cord-332422-s15o0hie	174	3	mouse	mouse	NN
cord-332422-s15o0hie	174	4	and	and	CC
cord-332422-s15o0hie	174	5	human	human	JJ
cord-332422-s15o0hie	174	6	OCLN	OCLN	NNP
cord-332422-s15o0hie	174	7	chimeras	chimera	NNS
cord-332422-s15o0hie	174	8	,	,	,
cord-332422-s15o0hie	174	9	the	the	DT
cord-332422-s15o0hie	174	10	species	specie	NNS
cord-332422-s15o0hie	174	11	determinant	determinant	NN
cord-332422-s15o0hie	174	12	for	for	IN
cord-332422-s15o0hie	174	13	HCV	HCV	NNP
cord-332422-s15o0hie	174	14	entry	entry	NN
cord-332422-s15o0hie	174	15	was	be	VBD
cord-332422-s15o0hie	174	16	mapped	map	VBN
cord-332422-s15o0hie	174	17	to	to	IN
cord-332422-s15o0hie	174	18	the	the	DT
cord-332422-s15o0hie	174	19	second	second	JJ
cord-332422-s15o0hie	174	20	extracellular	extracellular	JJ
cord-332422-s15o0hie	174	21	loop	loop	NN
cord-332422-s15o0hie	174	22	[	[	-LRB-
cord-332422-s15o0hie	174	23	55	55	CD
cord-332422-s15o0hie	174	24	]	]	-RRB-
cord-332422-s15o0hie	175	1	(	(	-LRB-
cord-332422-s15o0hie	175	2	Figure	figure	NN
cord-332422-s15o0hie	175	3	2	2	CD
cord-332422-s15o0hie	175	4	)	)	-RRB-
cord-332422-s15o0hie	175	5	.	.	.
cord-332422-s15o0hie	176	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	176	2	,	,	,
cord-332422-s15o0hie	176	3	alaninescanning	alaninescanning	NN
cord-332422-s15o0hie	176	4	mutagenesis	mutagenesis	NN
cord-332422-s15o0hie	176	5	of	of	IN
cord-332422-s15o0hie	176	6	the	the	DT
cord-332422-s15o0hie	176	7	two	two	CD
cord-332422-s15o0hie	176	8	OCLN	ocln	NN
cord-332422-s15o0hie	176	9	extracellular	extracellular	JJ
cord-332422-s15o0hie	176	10	loops	loop	NNS
cord-332422-s15o0hie	176	11	has	have	VBZ
cord-332422-s15o0hie	176	12	revealed	reveal	VBN
cord-332422-s15o0hie	176	13	that	that	IN
cord-332422-s15o0hie	176	14	the	the	DT
cord-332422-s15o0hie	176	15	second	second	JJ
cord-332422-s15o0hie	176	16	part	part	NN
cord-332422-s15o0hie	176	17	of	of	IN
cord-332422-s15o0hie	176	18	the	the	DT
cord-332422-s15o0hie	176	19	second	second	JJ
cord-332422-s15o0hie	176	20	loop	loop	NN
cord-332422-s15o0hie	176	21	is	be	VBZ
cord-332422-s15o0hie	176	22	required	require	VBN
cord-332422-s15o0hie	176	23	for	for	IN
cord-332422-s15o0hie	176	24	HCV	HCV	NNP
cord-332422-s15o0hie	176	25	entry	entry	NN
cord-332422-s15o0hie	176	26	.	.	.
cord-332422-s15o0hie	177	1	This	this	DT
cord-332422-s15o0hie	177	2	region	region	NN
cord-332422-s15o0hie	177	3	is	be	VBZ
cord-332422-s15o0hie	177	4	flanked	flank	VBN
cord-332422-s15o0hie	177	5	by	by	IN
cord-332422-s15o0hie	177	6	two	two	CD
cord-332422-s15o0hie	177	7	cysteines	cysteine	NNS
cord-332422-s15o0hie	177	8	for	for	IN
cord-332422-s15o0hie	177	9	which	which	WDT
cord-332422-s15o0hie	177	10	the	the	DT
cord-332422-s15o0hie	177	11	mutation	mutation	NN
cord-332422-s15o0hie	177	12	abolishes	abolish	VBZ
cord-332422-s15o0hie	177	13	HCV	HCV	NNP
cord-332422-s15o0hie	177	14	infection	infection	NN
cord-332422-s15o0hie	177	15	,	,	,
cord-332422-s15o0hie	177	16	suggesting	suggest	VBG
cord-332422-s15o0hie	177	17	that	that	IN
cord-332422-s15o0hie	177	18	this	this	DT
cord-332422-s15o0hie	177	19	region	region	NN
cord-332422-s15o0hie	177	20	might	may	MD
cord-332422-s15o0hie	177	21	be	be	VB
cord-332422-s15o0hie	177	22	folded	fold	VBN
cord-332422-s15o0hie	177	23	by	by	IN
cord-332422-s15o0hie	177	24	a	a	DT
cord-332422-s15o0hie	177	25	disulfide	disulfide	JJ
cord-332422-s15o0hie	177	26	bond	bond	NN
cord-332422-s15o0hie	177	27	.	.	.
cord-332422-s15o0hie	178	1	OCLN	ocln	NN
cord-332422-s15o0hie	178	2	expression	expression	NN
cord-332422-s15o0hie	178	3	on	on	IN
cord-332422-s15o0hie	178	4	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	178	5	as	as	RB
cord-332422-s15o0hie	178	6	well	well	RB
cord-332422-s15o0hie	178	7	as	as	IN
cord-332422-s15o0hie	178	8	HCV	HCV	NNP
cord-332422-s15o0hie	178	9	entry	entry	NN
cord-332422-s15o0hie	178	10	is	be	VBZ
cord-332422-s15o0hie	178	11	increased	increase	VBN
cord-332422-s15o0hie	178	12	upon	upon	IN
cord-332422-s15o0hie	178	13	glucocorticoid	glucocorticoid	NN
cord-332422-s15o0hie	178	14	treatment	treatment	NN
cord-332422-s15o0hie	178	15	[	[	-LRB-
cord-332422-s15o0hie	178	16	56	56	CD
cord-332422-s15o0hie	178	17	]	]	-RRB-
cord-332422-s15o0hie	178	18	.	.	.
cord-332422-s15o0hie	179	1	In	in	IN
cord-332422-s15o0hie	179	2	contrast	contrast	NN
cord-332422-s15o0hie	179	3	,	,	,
cord-332422-s15o0hie	179	4	OCLN	ocln	NN
cord-332422-s15o0hie	179	5	expression	expression	NN
cord-332422-s15o0hie	179	6	is	be	VBZ
cord-332422-s15o0hie	179	7	downregulated	downregulate	VBN
cord-332422-s15o0hie	179	8	upon	upon	IN
cord-332422-s15o0hie	179	9	HCV	HCV	NNP
cord-332422-s15o0hie	179	10	infection	infection	NN
cord-332422-s15o0hie	179	11	probably	probably	RB
cord-332422-s15o0hie	179	12	to	to	TO
cord-332422-s15o0hie	179	13	prevent	prevent	VB
cord-332422-s15o0hie	179	14	super	super	NN
cord-332422-s15o0hie	179	15	-	-	NN
cord-332422-s15o0hie	179	16	infection	infection	NN
cord-332422-s15o0hie	179	17	[	[	-LRB-
cord-332422-s15o0hie	179	18	54	54	CD
cord-332422-s15o0hie	179	19	,	,	,
cord-332422-s15o0hie	179	20	57	57	CD
cord-332422-s15o0hie	179	21	]	]	-RRB-
cord-332422-s15o0hie	179	22	.	.	.
cord-332422-s15o0hie	180	1	In	in	IN
cord-332422-s15o0hie	180	2	the	the	DT
cord-332422-s15o0hie	180	3	liver	liver	NN
cord-332422-s15o0hie	180	4	,	,	,
cord-332422-s15o0hie	180	5	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	180	6	are	be	VBP
cord-332422-s15o0hie	180	7	organized	organize	VBN
cord-332422-s15o0hie	180	8	in	in	IN
cord-332422-s15o0hie	180	9	plates	plate	NNS
cord-332422-s15o0hie	180	10	of	of	IN
cord-332422-s15o0hie	180	11	single	single	JJ
cord-332422-s15o0hie	180	12	cell	cell	NN
cord-332422-s15o0hie	180	13	layers	layer	NNS
cord-332422-s15o0hie	180	14	that	that	WDT
cord-332422-s15o0hie	180	15	are	be	VBP
cord-332422-s15o0hie	180	16	separated	separate	VBN
cord-332422-s15o0hie	180	17	by	by	IN
cord-332422-s15o0hie	180	18	sinusoid	sinusoid	JJ
cord-332422-s15o0hie	180	19	vessels	vessel	NNS
cord-332422-s15o0hie	180	20	.	.	.
cord-332422-s15o0hie	181	1	Endothelial	endothelial	JJ
cord-332422-s15o0hie	181	2	cells	cell	NNS
cord-332422-s15o0hie	181	3	and	and	CC
cord-332422-s15o0hie	181	4	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	181	5	are	be	VBP
cord-332422-s15o0hie	181	6	separated	separate	VBN
cord-332422-s15o0hie	181	7	by	by	IN
cord-332422-s15o0hie	181	8	the	the	DT
cord-332422-s15o0hie	181	9	space	space	NN
cord-332422-s15o0hie	181	10	of	of	IN
cord-332422-s15o0hie	181	11	Disse	Disse	NNP
cord-332422-s15o0hie	181	12	which	which	WDT
cord-332422-s15o0hie	181	13	drains	drain	VBZ
cord-332422-s15o0hie	181	14	lymph	lymph	NN
cord-332422-s15o0hie	181	15	into	into	IN
cord-332422-s15o0hie	181	16	the	the	DT
cord-332422-s15o0hie	181	17	portal	portal	JJ
cord-332422-s15o0hie	181	18	tract	tract	NN
cord-332422-s15o0hie	181	19	lymphatics	lymphatic	NNS
cord-332422-s15o0hie	181	20	(	(	-LRB-
cord-332422-s15o0hie	181	21	Figure	figure	NN
cord-332422-s15o0hie	181	22	2	2	CD
cord-332422-s15o0hie	181	23	)	)	-RRB-
cord-332422-s15o0hie	181	24	.	.	.
cord-332422-s15o0hie	182	1	Basolateral	Basolateral	NNP
cord-332422-s15o0hie	182	2	domains	domain	NNS
cord-332422-s15o0hie	182	3	of	of	IN
cord-332422-s15o0hie	182	4	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	182	5	face	face	VBP
cord-332422-s15o0hie	182	6	the	the	DT
cord-332422-s15o0hie	182	7	space	space	NN
cord-332422-s15o0hie	182	8	of	of	IN
cord-332422-s15o0hie	182	9	Disse	Disse	NNP
cord-332422-s15o0hie	182	10	whereas	whereas	IN
cord-332422-s15o0hie	182	11	apical	apical	JJ
cord-332422-s15o0hie	182	12	domains	domain	NNS
cord-332422-s15o0hie	182	13	form	form	VBP
cord-332422-s15o0hie	182	14	tightly	tightly	RB
cord-332422-s15o0hie	182	15	closed	closed	JJ
cord-332422-s15o0hie	182	16	spaces	space	NNS
cord-332422-s15o0hie	182	17	called	call	VBD
cord-332422-s15o0hie	182	18	the	the	DT
cord-332422-s15o0hie	182	19	canaliculi	canaliculi	NNP
cord-332422-s15o0hie	182	20	in	in	IN
cord-332422-s15o0hie	182	21	which	which	WDT
cord-332422-s15o0hie	182	22	the	the	DT
cord-332422-s15o0hie	182	23	bile	bile	NN
cord-332422-s15o0hie	182	24	is	be	VBZ
cord-332422-s15o0hie	182	25	secreted	secrete	VBN
cord-332422-s15o0hie	182	26	.	.	.
cord-332422-s15o0hie	183	1	TJs	TJs	NNP
cord-332422-s15o0hie	183	2	act	act	NNP
cord-332422-s15o0hie	183	3	as	as	IN
cord-332422-s15o0hie	183	4	a	a	DT
cord-332422-s15o0hie	183	5	barrier	barrier	NN
cord-332422-s15o0hie	183	6	between	between	IN
cord-332422-s15o0hie	183	7	the	the	DT
cord-332422-s15o0hie	183	8	two	two	CD
cord-332422-s15o0hie	183	9	spaces	space	NNS
cord-332422-s15o0hie	183	10	and	and	CC
cord-332422-s15o0hie	183	11	maintain	maintain	VB
cord-332422-s15o0hie	183	12	the	the	DT
cord-332422-s15o0hie	183	13	separation	separation	NN
cord-332422-s15o0hie	183	14	between	between	IN
cord-332422-s15o0hie	183	15	both	both	DT
cord-332422-s15o0hie	183	16	membrane	membrane	NN
cord-332422-s15o0hie	183	17	domains	domain	NNS
cord-332422-s15o0hie	183	18	maintaining	maintain	VBG
cord-332422-s15o0hie	183	19	their	-PRON-	PRP$
cord-332422-s15o0hie	183	20	distinct	distinct	JJ
cord-332422-s15o0hie	183	21	molecular	molecular	JJ
cord-332422-s15o0hie	183	22	compositions	composition	NNS
cord-332422-s15o0hie	183	23	.	.	.
cord-332422-s15o0hie	184	1	Cell	cell	NN
cord-332422-s15o0hie	184	2	polarity	polarity	NN
cord-332422-s15o0hie	184	3	is	be	VBZ
cord-332422-s15o0hie	184	4	achieved	achieve	VBN
cord-332422-s15o0hie	184	5	by	by	IN
cord-332422-s15o0hie	184	6	a	a	DT
cord-332422-s15o0hie	184	7	complex	complex	JJ
cord-332422-s15o0hie	184	8	regulation	regulation	NN
cord-332422-s15o0hie	184	9	of	of	IN
cord-332422-s15o0hie	184	10	intracellular	intracellular	JJ
cord-332422-s15o0hie	184	11	trafficking	trafficking	NN
cord-332422-s15o0hie	184	12	to	to	TO
cord-332422-s15o0hie	184	13	deliver	deliver	VB
cord-332422-s15o0hie	184	14	newly	newly	RB
cord-332422-s15o0hie	184	15	synthesized	synthesize	VBN
cord-332422-s15o0hie	184	16	proteins	protein	NNS
cord-332422-s15o0hie	184	17	to	to	IN
cord-332422-s15o0hie	184	18	the	the	DT
cord-332422-s15o0hie	184	19	suitable	suitable	JJ
cord-332422-s15o0hie	184	20	pole	pole	NN
cord-332422-s15o0hie	184	21	.	.	.
cord-332422-s15o0hie	185	1	It	-PRON-	PRP
cord-332422-s15o0hie	185	2	is	be	VBZ
cord-332422-s15o0hie	185	3	believed	believe	VBN
cord-332422-s15o0hie	185	4	that	that	IN
cord-332422-s15o0hie	185	5	HCV	HCV	NNP
cord-332422-s15o0hie	185	6	enters	enter	VBZ
cord-332422-s15o0hie	185	7	the	the	DT
cord-332422-s15o0hie	185	8	liver	liver	NN
cord-332422-s15o0hie	185	9	through	through	IN
cord-332422-s15o0hie	185	10	blood	blood	NN
cord-332422-s15o0hie	185	11	flow	flow	NN
cord-332422-s15o0hie	185	12	and	and	CC
cord-332422-s15o0hie	185	13	makes	make	VBZ
cord-332422-s15o0hie	185	14	contact	contact	NN
cord-332422-s15o0hie	185	15	with	with	IN
cord-332422-s15o0hie	185	16	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	185	17	at	at	IN
cord-332422-s15o0hie	185	18	the	the	DT
cord-332422-s15o0hie	185	19	basolateral	basolateral	JJ
cord-332422-s15o0hie	185	20	membrane	membrane	NN
cord-332422-s15o0hie	185	21	.	.	.
cord-332422-s15o0hie	186	1	In	in	IN
cord-332422-s15o0hie	186	2	order	order	NN
cord-332422-s15o0hie	186	3	to	to	TO
cord-332422-s15o0hie	186	4	infect	infect	VB
cord-332422-s15o0hie	186	5	cells	cell	NNS
cord-332422-s15o0hie	186	6	and	and	CC
cord-332422-s15o0hie	186	7	propagate	propagate	VBP
cord-332422-s15o0hie	186	8	,	,	,
cord-332422-s15o0hie	186	9	the	the	DT
cord-332422-s15o0hie	186	10	virus	virus	NN
cord-332422-s15o0hie	186	11	needs	need	VBZ
cord-332422-s15o0hie	186	12	to	to	TO
cord-332422-s15o0hie	186	13	overcome	overcome	VB
cord-332422-s15o0hie	186	14	the	the	DT
cord-332422-s15o0hie	186	15	complex	complex	JJ
cord-332422-s15o0hie	186	16	organization	organization	NN
cord-332422-s15o0hie	186	17	of	of	IN
cord-332422-s15o0hie	186	18	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	186	19	.	.	.
cord-332422-s15o0hie	187	1	The	the	DT
cord-332422-s15o0hie	187	2	mechanisms	mechanism	NNS
cord-332422-s15o0hie	187	3	leading	lead	VBG
cord-332422-s15o0hie	187	4	to	to	IN
cord-332422-s15o0hie	187	5	HCV	HCV	NNP
cord-332422-s15o0hie	187	6	entry	entry	NN
cord-332422-s15o0hie	187	7	into	into	IN
cord-332422-s15o0hie	187	8	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	187	9	are	be	VBP
cord-332422-s15o0hie	187	10	still	still	RB
cord-332422-s15o0hie	187	11	poorly	poorly	RB
cord-332422-s15o0hie	187	12	understood	understand	VBN
cord-332422-s15o0hie	187	13	.	.	.
cord-332422-s15o0hie	188	1	To	to	IN
cord-332422-s15o0hie	188	2	date	date	NN
cord-332422-s15o0hie	188	3	,	,	,
cord-332422-s15o0hie	188	4	accumulated	accumulate	VBN
cord-332422-s15o0hie	188	5	data	datum	NNS
cord-332422-s15o0hie	188	6	indicate	indicate	VBP
cord-332422-s15o0hie	188	7	that	that	IN
cord-332422-s15o0hie	188	8	HCV	HCV	NNP
cord-332422-s15o0hie	188	9	entry	entry	NN
cord-332422-s15o0hie	188	10	is	be	VBZ
cord-332422-s15o0hie	188	11	a	a	DT
cord-332422-s15o0hie	188	12	complex	complex	JJ
cord-332422-s15o0hie	188	13	multistep	multistep	NN
cord-332422-s15o0hie	188	14	process	process	NN
cord-332422-s15o0hie	188	15	involving	involve	VBG
cord-332422-s15o0hie	188	16	numerous	numerous	JJ
cord-332422-s15o0hie	188	17	components	component	NNS
cord-332422-s15o0hie	188	18	as	as	RB
cord-332422-s15o0hie	188	19	well	well	RB
cord-332422-s15o0hie	188	20	as	as	IN
cord-332422-s15o0hie	188	21	the	the	DT
cord-332422-s15o0hie	188	22	constraints	constraint	NNS
cord-332422-s15o0hie	188	23	of	of	IN
cord-332422-s15o0hie	188	24	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	188	25	polarity	polarity	NN
cord-332422-s15o0hie	188	26	.	.	.
cord-332422-s15o0hie	189	1	In	in	IN
cord-332422-s15o0hie	189	2	vivo	vivo	NN
cord-332422-s15o0hie	189	3	,	,	,
cord-332422-s15o0hie	189	4	HCV	HCV	NNP
cord-332422-s15o0hie	189	5	enters	enter	VBZ
cord-332422-s15o0hie	189	6	the	the	DT
cord-332422-s15o0hie	189	7	liver	liver	NN
cord-332422-s15o0hie	189	8	through	through	IN
cord-332422-s15o0hie	189	9	the	the	DT
cord-332422-s15o0hie	189	10	sinusoidal	sinusoidal	JJ
cord-332422-s15o0hie	189	11	blood	blood	NN
cord-332422-s15o0hie	189	12	.	.	.
cord-332422-s15o0hie	190	1	Before	before	IN
cord-332422-s15o0hie	190	2	gaining	gain	VBG
cord-332422-s15o0hie	190	3	access	access	NN
cord-332422-s15o0hie	190	4	to	to	IN
cord-332422-s15o0hie	190	5	the	the	DT
cord-332422-s15o0hie	190	6	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	190	7	,	,	,
cord-332422-s15o0hie	190	8	this	this	DT
cord-332422-s15o0hie	190	9	virus	virus	NN
cord-332422-s15o0hie	190	10	first	first	RB
cord-332422-s15o0hie	190	11	needs	need	VBZ
cord-332422-s15o0hie	190	12	to	to	TO
cord-332422-s15o0hie	190	13	cross	cross	VB
cord-332422-s15o0hie	190	14	the	the	DT
cord-332422-s15o0hie	190	15	sinusoidal	sinusoidal	JJ
cord-332422-s15o0hie	190	16	endothelial	endothelial	JJ
cord-332422-s15o0hie	190	17	cell	cell	NN
cord-332422-s15o0hie	190	18	barrier	barrier	NN
cord-332422-s15o0hie	190	19	.	.	.
cord-332422-s15o0hie	191	1	C	c	NN
cord-332422-s15o0hie	191	2	-	-	HYPH
cord-332422-s15o0hie	191	3	type	type	NN
cord-332422-s15o0hie	191	4	lectins	lectin	NNS
cord-332422-s15o0hie	191	5	have	have	VBP
cord-332422-s15o0hie	191	6	been	be	VBN
cord-332422-s15o0hie	191	7	proposed	propose	VBN
cord-332422-s15o0hie	191	8	to	to	TO
cord-332422-s15o0hie	191	9	play	play	VB
cord-332422-s15o0hie	191	10	a	a	DT
cord-332422-s15o0hie	191	11	role	role	NN
cord-332422-s15o0hie	191	12	in	in	IN
cord-332422-s15o0hie	191	13	assisting	assist	VBG
cord-332422-s15o0hie	191	14	the	the	DT
cord-332422-s15o0hie	191	15	virus	virus	NN
cord-332422-s15o0hie	191	16	cross	cross	VB
cord-332422-s15o0hie	191	17	the	the	DT
cord-332422-s15o0hie	191	18	liver	liver	NN
cord-332422-s15o0hie	191	19	endothelium	endothelium	NN
cord-332422-s15o0hie	191	20	(	(	-LRB-
cord-332422-s15o0hie	191	21	reviewed	review	VBN
cord-332422-s15o0hie	191	22	in	in	IN
cord-332422-s15o0hie	191	23	[	[	-LRB-
cord-332422-s15o0hie	191	24	5	5	CD
cord-332422-s15o0hie	191	25	]	]	-RRB-
cord-332422-s15o0hie	191	26	)	)	-RRB-
cord-332422-s15o0hie	191	27	,	,	,
cord-332422-s15o0hie	191	28	however	however	RB
cord-332422-s15o0hie	191	29	,	,	,
cord-332422-s15o0hie	191	30	this	this	DT
cord-332422-s15o0hie	191	31	remains	remain	VBZ
cord-332422-s15o0hie	191	32	to	to	TO
cord-332422-s15o0hie	191	33	be	be	VB
cord-332422-s15o0hie	191	34	demonstrated	demonstrate	VBN
cord-332422-s15o0hie	191	35	.	.	.
cord-332422-s15o0hie	192	1	HCV	HCV	NNP
cord-332422-s15o0hie	192	2	attachment	attachment	NN
cord-332422-s15o0hie	192	3	to	to	IN
cord-332422-s15o0hie	192	4	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	192	5	is	be	VBZ
cord-332422-s15o0hie	192	6	likely	likely	RB
cord-332422-s15o0hie	192	7	first	first	RB
cord-332422-s15o0hie	192	8	mediated	mediate	VBN
cord-332422-s15o0hie	192	9	by	by	IN
cord-332422-s15o0hie	192	10	heparan	heparan	JJ
cord-332422-s15o0hie	192	11	sulfate	sulfate	NN
cord-332422-s15o0hie	192	12	proteoglycans	proteoglycan	NNS
cord-332422-s15o0hie	192	13	(	(	-LRB-
cord-332422-s15o0hie	192	14	reviewed	review	VBN
cord-332422-s15o0hie	192	15	in	in	IN
cord-332422-s15o0hie	192	16	[	[	-LRB-
cord-332422-s15o0hie	192	17	58	58	CD
cord-332422-s15o0hie	192	18	]	]	-RRB-
cord-332422-s15o0hie	192	19	)	)	-RRB-
cord-332422-s15o0hie	192	20	.	.	.
cord-332422-s15o0hie	193	1	Due	due	IN
cord-332422-s15o0hie	193	2	to	to	IN
cord-332422-s15o0hie	193	3	the	the	DT
cord-332422-s15o0hie	193	4	association	association	NN
cord-332422-s15o0hie	193	5	of	of	IN
cord-332422-s15o0hie	193	6	the	the	DT
cord-332422-s15o0hie	193	7	virion	virion	NN
cord-332422-s15o0hie	193	8	with	with	IN
cord-332422-s15o0hie	193	9	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	193	10	,	,	,
cord-332422-s15o0hie	193	11	the	the	DT
cord-332422-s15o0hie	193	12	LDLR	LDLR	NNP
cord-332422-s15o0hie	193	13	has	have	VBZ
cord-332422-s15o0hie	193	14	also	also	RB
cord-332422-s15o0hie	193	15	been	be	VBN
cord-332422-s15o0hie	193	16	proposed	propose	VBN
cord-332422-s15o0hie	193	17	to	to	TO
cord-332422-s15o0hie	193	18	play	play	VB
cord-332422-s15o0hie	193	19	a	a	DT
cord-332422-s15o0hie	193	20	role	role	NN
cord-332422-s15o0hie	193	21	in	in	IN
cord-332422-s15o0hie	193	22	the	the	DT
cord-332422-s15o0hie	193	23	early	early	JJ
cord-332422-s15o0hie	193	24	phase	phase	NN
cord-332422-s15o0hie	193	25	of	of	IN
cord-332422-s15o0hie	193	26	HCV	HCV	NNP
cord-332422-s15o0hie	193	27	entry	entry	NN
cord-332422-s15o0hie	193	28	(	(	-LRB-
cord-332422-s15o0hie	193	29	reviewed	review	VBN
cord-332422-s15o0hie	193	30	in	in	IN
cord-332422-s15o0hie	193	31	[	[	-LRB-
cord-332422-s15o0hie	193	32	5	5	CD
cord-332422-s15o0hie	193	33	]	]	-RRB-
cord-332422-s15o0hie	193	34	)	)	-RRB-
cord-332422-s15o0hie	193	35	.	.	.
cord-332422-s15o0hie	194	1	LDLR	LDLR	NNP
cord-332422-s15o0hie	194	2	mediates	mediate	VBZ
cord-332422-s15o0hie	194	3	internalization	internalization	NN
cord-332422-s15o0hie	194	4	of	of	IN
cord-332422-s15o0hie	194	5	low	low	JJ
cord-332422-s15o0hie	194	6	density	density	NN
cord-332422-s15o0hie	194	7	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	194	8	that	that	WDT
cord-332422-s15o0hie	194	9	are	be	VBP
cord-332422-s15o0hie	194	10	released	release	VBN
cord-332422-s15o0hie	194	11	from	from	IN
cord-332422-s15o0hie	194	12	the	the	DT
cord-332422-s15o0hie	194	13	receptor	receptor	NN
cord-332422-s15o0hie	194	14	upon	upon	IN
cord-332422-s15o0hie	194	15	pH	pH	NNP
cord-332422-s15o0hie	194	16	decrease	decrease	NN
cord-332422-s15o0hie	194	17	in	in	IN
cord-332422-s15o0hie	194	18	endosomes	endosome	NNS
cord-332422-s15o0hie	194	19	.	.	.
cord-332422-s15o0hie	195	1	It	-PRON-	PRP
cord-332422-s15o0hie	195	2	has	have	VBZ
cord-332422-s15o0hie	195	3	been	be	VBN
cord-332422-s15o0hie	195	4	shown	show	VBN
cord-332422-s15o0hie	195	5	that	that	IN
cord-332422-s15o0hie	195	6	HCV	HCV	NNP
cord-332422-s15o0hie	195	7	infection	infection	NN
cord-332422-s15o0hie	195	8	is	be	VBZ
cord-332422-s15o0hie	195	9	correlated	correlate	VBN
cord-332422-s15o0hie	195	10	with	with	IN
cord-332422-s15o0hie	195	11	LDLR	LDLR	NNP
cord-332422-s15o0hie	195	12	expression	expression	NN
cord-332422-s15o0hie	195	13	in	in	IN
cord-332422-s15o0hie	195	14	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	195	15	and	and	CC
cord-332422-s15o0hie	195	16	can	can	MD
cord-332422-s15o0hie	195	17	be	be	VB
cord-332422-s15o0hie	195	18	inhibited	inhibit	VBN
cord-332422-s15o0hie	195	19	by	by	IN
cord-332422-s15o0hie	195	20	LDLR	LDLR	NNP
cord-332422-s15o0hie	195	21	ligands	ligand	NNS
cord-332422-s15o0hie	195	22	.	.	.
cord-332422-s15o0hie	196	1	It	-PRON-	PRP
cord-332422-s15o0hie	196	2	is	be	VBZ
cord-332422-s15o0hie	196	3	therefore	therefore	RB
cord-332422-s15o0hie	196	4	possible	possible	JJ
cord-332422-s15o0hie	196	5	that	that	IN
cord-332422-s15o0hie	196	6	the	the	DT
cord-332422-s15o0hie	196	7	lipoviroparticles	lipoviroparticle	NNS
cord-332422-s15o0hie	196	8	interact	interact	VBP
cord-332422-s15o0hie	196	9	with	with	IN
cord-332422-s15o0hie	196	10	LDLR	LDLR	NNP
cord-332422-s15o0hie	196	11	through	through	IN
cord-332422-s15o0hie	196	12	their	-PRON-	PRP$
cord-332422-s15o0hie	196	13	apoB	apoB	NNS
cord-332422-s15o0hie	196	14	and/or	and/or	CC
cord-332422-s15o0hie	196	15	apoE	apoe	CC
cord-332422-s15o0hie	196	16	components	component	NNS
cord-332422-s15o0hie	196	17	,	,	,
cord-332422-s15o0hie	196	18	and	and	CC
cord-332422-s15o0hie	196	19	that	that	IN
cord-332422-s15o0hie	196	20	these	these	DT
cord-332422-s15o0hie	196	21	interactions	interaction	NNS
cord-332422-s15o0hie	196	22	are	be	VBP
cord-332422-s15o0hie	196	23	likely	likely	RB
cord-332422-s15o0hie	196	24	modulated	modulate	VBN
cord-332422-s15o0hie	196	25	by	by	IN
cord-332422-s15o0hie	196	26	the	the	DT
cord-332422-s15o0hie	196	27	processing	processing	NN
cord-332422-s15o0hie	196	28	of	of	IN
cord-332422-s15o0hie	196	29	LVP	LVP	NNP
cord-332422-s15o0hie	196	30	by	by	IN
cord-332422-s15o0hie	196	31	LPL	LPL	NNP
cord-332422-s15o0hie	196	32	.	.	.
cord-332422-s15o0hie	197	1	Although	although	IN
cord-332422-s15o0hie	197	2	recent	recent	JJ
cord-332422-s15o0hie	197	3	data	datum	NNS
cord-332422-s15o0hie	197	4	are	be	VBP
cord-332422-s15o0hie	197	5	in	in	IN
cord-332422-s15o0hie	197	6	favor	favor	NN
cord-332422-s15o0hie	197	7	of	of	IN
cord-332422-s15o0hie	197	8	the	the	DT
cord-332422-s15o0hie	197	9	involvement	involvement	NN
cord-332422-s15o0hie	197	10	of	of	IN
cord-332422-s15o0hie	197	11	LDLR	LDLR	NNP
cord-332422-s15o0hie	197	12	in	in	IN
cord-332422-s15o0hie	197	13	the	the	DT
cord-332422-s15o0hie	197	14	HCV	HCV	NNP
cord-332422-s15o0hie	197	15	life	life	NN
cord-332422-s15o0hie	197	16	cycle	cycle	NN
cord-332422-s15o0hie	197	17	[	[	-LRB-
cord-332422-s15o0hie	197	18	59	59	CD
cord-332422-s15o0hie	197	19	,	,	,
cord-332422-s15o0hie	197	20	60	60	CD
cord-332422-s15o0hie	197	21	]	]	-RRB-
cord-332422-s15o0hie	197	22	,	,	,
cord-332422-s15o0hie	197	23	the	the	DT
cord-332422-s15o0hie	197	24	role	role	NN
cord-332422-s15o0hie	197	25	of	of	IN
cord-332422-s15o0hie	197	26	this	this	DT
cord-332422-s15o0hie	197	27	receptor	receptor	NN
cord-332422-s15o0hie	197	28	in	in	IN
cord-332422-s15o0hie	197	29	HCV	HCV	NNP
cord-332422-s15o0hie	197	30	entry	entry	NN
cord-332422-s15o0hie	197	31	remains	remain	VBZ
cord-332422-s15o0hie	197	32	unclear	unclear	JJ
cord-332422-s15o0hie	197	33	.	.	.
cord-332422-s15o0hie	198	1	After	after	IN
cord-332422-s15o0hie	198	2	binding	bind	VBG
cord-332422-s15o0hie	198	3	to	to	IN
cord-332422-s15o0hie	198	4	the	the	DT
cord-332422-s15o0hie	198	5	cell	cell	NN
cord-332422-s15o0hie	198	6	surface	surface	NN
cord-332422-s15o0hie	198	7	with	with	IN
cord-332422-s15o0hie	198	8	the	the	DT
cord-332422-s15o0hie	198	9	help	help	NN
cord-332422-s15o0hie	198	10	of	of	IN
cord-332422-s15o0hie	198	11	heparan	heparan	JJ
cord-332422-s15o0hie	198	12	sulfate	sulfate	NN
cord-332422-s15o0hie	198	13	proteoglycans	proteoglycan	NNS
cord-332422-s15o0hie	198	14	,	,	,
cord-332422-s15o0hie	198	15	the	the	DT
cord-332422-s15o0hie	198	16	virus	virus	NN
cord-332422-s15o0hie	198	17	then	then	RB
cord-332422-s15o0hie	198	18	interacts	interact	VBZ
cord-332422-s15o0hie	198	19	with	with	IN
cord-332422-s15o0hie	198	20	specific	specific	JJ
cord-332422-s15o0hie	198	21	entry	entry	NN
cord-332422-s15o0hie	198	22	factors	factor	NNS
cord-332422-s15o0hie	198	23	.	.	.
cord-332422-s15o0hie	199	1	There	there	EX
cord-332422-s15o0hie	199	2	is	be	VBZ
cord-332422-s15o0hie	199	3	evidence	evidence	NN
cord-332422-s15o0hie	199	4	that	that	IN
cord-332422-s15o0hie	199	5	the	the	DT
cord-332422-s15o0hie	199	6	E2	E2	NNP
cord-332422-s15o0hie	199	7	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	199	8	can	can	MD
cord-332422-s15o0hie	199	9	interact	interact	VB
cord-332422-s15o0hie	199	10	with	with	IN
cord-332422-s15o0hie	199	11	SRB1	SRB1	NNP
cord-332422-s15o0hie	199	12	and	and	CC
cord-332422-s15o0hie	199	13	CD81	CD81	NNP
cord-332422-s15o0hie	199	14	.	.	.
cord-332422-s15o0hie	200	1	Recently	recently	RB
cord-332422-s15o0hie	200	2	,	,	,
cord-332422-s15o0hie	200	3	it	-PRON-	PRP
cord-332422-s15o0hie	200	4	has	have	VBZ
cord-332422-s15o0hie	200	5	been	be	VBN
cord-332422-s15o0hie	200	6	proposed	propose	VBN
cord-332422-s15o0hie	200	7	that	that	IN
cord-332422-s15o0hie	200	8	HCV	HCV	NNP
cord-332422-s15o0hie	200	9	virions	virion	NNS
cord-332422-s15o0hie	200	10	first	first	RB
cord-332422-s15o0hie	200	11	interact	interact	VBP
cord-332422-s15o0hie	200	12	with	with	IN
cord-332422-s15o0hie	200	13	SRB1	SRB1	NNP
cord-332422-s15o0hie	200	14	[	[	-LRB-
cord-332422-s15o0hie	200	15	28	28	CD
cord-332422-s15o0hie	200	16	]	]	-RRB-
cord-332422-s15o0hie	200	17	.	.	.
cord-332422-s15o0hie	201	1	This	this	DT
cord-332422-s15o0hie	201	2	is	be	VBZ
cord-332422-s15o0hie	201	3	in	in	IN
cord-332422-s15o0hie	201	4	line	line	NN
cord-332422-s15o0hie	201	5	with	with	IN
cord-332422-s15o0hie	201	6	the	the	DT
cord-332422-s15o0hie	201	7	observation	observation	NN
cord-332422-s15o0hie	201	8	that	that	IN
cord-332422-s15o0hie	201	9	HCV	HCV	NNP
cord-332422-s15o0hie	201	10	virions	virion	NNS
cord-332422-s15o0hie	201	11	can	can	MD
cord-332422-s15o0hie	201	12	bind	bind	VB
cord-332422-s15o0hie	201	13	to	to	IN
cord-332422-s15o0hie	201	14	CHO	CHO	NNP
cord-332422-s15o0hie	201	15	cells	cell	NNS
cord-332422-s15o0hie	201	16	expressing	express	VBG
cord-332422-s15o0hie	201	17	SRB1	SRB1	NNP
cord-332422-s15o0hie	201	18	,	,	,
cord-332422-s15o0hie	201	19	but	but	CC
cord-332422-s15o0hie	201	20	not	not	RB
cord-332422-s15o0hie	201	21	to	to	TO
cord-332422-s15o0hie	201	22	cells	cell	NNS
cord-332422-s15o0hie	201	23	expressing	express	VBG
cord-332422-s15o0hie	201	24	CD81	CD81	NNP
cord-332422-s15o0hie	201	25	[	[	-LRB-
cord-332422-s15o0hie	201	26	46	46	CD
cord-332422-s15o0hie	201	27	]	]	-RRB-
cord-332422-s15o0hie	201	28	.	.	.
cord-332422-s15o0hie	202	1	However	however	RB
cord-332422-s15o0hie	202	2	,	,	,
cord-332422-s15o0hie	202	3	it	-PRON-	PRP
cord-332422-s15o0hie	202	4	remains	remain	VBZ
cord-332422-s15o0hie	202	5	to	to	TO
cord-332422-s15o0hie	202	6	be	be	VB
cord-332422-s15o0hie	202	7	determined	determine	VBN
cord-332422-s15o0hie	202	8	whether	whether	IN
cord-332422-s15o0hie	202	9	SRB1	SRB1	NNP
cord-332422-s15o0hie	202	10	and	and	CC
cord-332422-s15o0hie	202	11	CD81	CD81	NNP
cord-332422-s15o0hie	202	12	form	form	VBP
cord-332422-s15o0hie	202	13	a	a	DT
cord-332422-s15o0hie	202	14	co	co	JJ
cord-332422-s15o0hie	202	15	-	-	NN
cord-332422-s15o0hie	202	16	receptor	receptor	JJ
cord-332422-s15o0hie	202	17	complex	complex	NN
cord-332422-s15o0hie	202	18	or	or	CC
cord-332422-s15o0hie	202	19	whether	whether	IN
cord-332422-s15o0hie	202	20	the	the	DT
cord-332422-s15o0hie	202	21	virus	virus	NN
cord-332422-s15o0hie	202	22	is	be	VBZ
cord-332422-s15o0hie	202	23	transferred	transfer	VBN
cord-332422-s15o0hie	202	24	from	from	IN
cord-332422-s15o0hie	202	25	SRB1	SRB1	NNP
cord-332422-s15o0hie	202	26	to	to	IN
cord-332422-s15o0hie	202	27	CD81	CD81	NNP
cord-332422-s15o0hie	202	28	.	.	.
cord-332422-s15o0hie	203	1	Currently	currently	RB
cord-332422-s15o0hie	203	2	,	,	,
cord-332422-s15o0hie	203	3	there	there	EX
cord-332422-s15o0hie	203	4	is	be	VBZ
cord-332422-s15o0hie	203	5	no	no	DT
cord-332422-s15o0hie	203	6	evidence	evidence	NN
cord-332422-s15o0hie	203	7	indicating	indicate	VBG
cord-332422-s15o0hie	203	8	that	that	IN
cord-332422-s15o0hie	203	9	HCV	HCV	NNP
cord-332422-s15o0hie	203	10	particles	particle	NNS
cord-332422-s15o0hie	203	11	directly	directly	RB
cord-332422-s15o0hie	203	12	interact	interact	VBP
cord-332422-s15o0hie	203	13	with	with	IN
cord-332422-s15o0hie	203	14	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	203	15	or	or	CC
cord-332422-s15o0hie	203	16	OCLN	ocln	NN
cord-332422-s15o0hie	203	17	.	.	.
cord-332422-s15o0hie	204	1	However	however	RB
cord-332422-s15o0hie	204	2	,	,	,
cord-332422-s15o0hie	204	3	it	-PRON-	PRP
cord-332422-s15o0hie	204	4	has	have	VBZ
cord-332422-s15o0hie	204	5	been	be	VBN
cord-332422-s15o0hie	204	6	shown	show	VBN
cord-332422-s15o0hie	204	7	that	that	IN
cord-332422-s15o0hie	204	8	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	204	9	and	and	CC
cord-332422-s15o0hie	204	10	CD81	CD81	NNP
cord-332422-s15o0hie	204	11	interact	interact	VBP
cord-332422-s15o0hie	204	12	in	in	IN
cord-332422-s15o0hie	204	13	fluorescence	fluorescence	NN
cord-332422-s15o0hie	204	14	resonance	resonance	NN
cord-332422-s15o0hie	204	15	energy	energy	NN
cord-332422-s15o0hie	204	16	transfer	transfer	NN
cord-332422-s15o0hie	204	17	(	(	-LRB-
cord-332422-s15o0hie	204	18	FRET	FRET	NNP
cord-332422-s15o0hie	204	19	)	)	-RRB-
cord-332422-s15o0hie	204	20	and	and	CC
cord-332422-s15o0hie	205	1	fluorescence	fluorescence	NN
cord-332422-s15o0hie	205	2	intensity	intensity	NN
cord-332422-s15o0hie	205	3	ratio	ratio	NN
cord-332422-s15o0hie	205	4	(	(	-LRB-
cord-332422-s15o0hie	205	5	FIR	fir	NN
cord-332422-s15o0hie	205	6	)	)	-RRB-
cord-332422-s15o0hie	205	7	assays	assay	NNS
cord-332422-s15o0hie	205	8	[	[	-LRB-
cord-332422-s15o0hie	205	9	61	61	CD
cord-332422-s15o0hie	205	10	,	,	,
cord-332422-s15o0hie	205	11	62	62	CD
cord-332422-s15o0hie	205	12	]	]	-RRB-
cord-332422-s15o0hie	205	13	,	,	,
cord-332422-s15o0hie	205	14	suggesting	suggest	VBG
cord-332422-s15o0hie	205	15	that	that	IN
cord-332422-s15o0hie	205	16	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	205	17	may	may	MD
cord-332422-s15o0hie	205	18	be	be	VB
cord-332422-s15o0hie	205	19	a	a	DT
cord-332422-s15o0hie	205	20	partner	partner	NN
cord-332422-s15o0hie	205	21	of	of	IN
cord-332422-s15o0hie	205	22	CD81	CD81	NNP
cord-332422-s15o0hie	205	23	in	in	IN
cord-332422-s15o0hie	205	24	a	a	DT
cord-332422-s15o0hie	205	25	HCV	HCV	NNP
cord-332422-s15o0hie	205	26	receptor	receptor	NN
cord-332422-s15o0hie	205	27	complex	complex	NN
cord-332422-s15o0hie	205	28	.	.	.
cord-332422-s15o0hie	206	1	Concordant	concordant	JJ
cord-332422-s15o0hie	206	2	with	with	IN
cord-332422-s15o0hie	206	3	this	this	DT
cord-332422-s15o0hie	206	4	hypothesis	hypothesis	NN
cord-332422-s15o0hie	206	5	,	,	,
cord-332422-s15o0hie	206	6	mutation	mutation	NN
cord-332422-s15o0hie	206	7	of	of	IN
cord-332422-s15o0hie	206	8	residues	residue	NNS
cord-332422-s15o0hie	206	9	32	32	CD
cord-332422-s15o0hie	206	10	and	and	CC
cord-332422-s15o0hie	206	11	48	48	CD
cord-332422-s15o0hie	206	12	in	in	IN
cord-332422-s15o0hie	206	13	the	the	DT
cord-332422-s15o0hie	206	14	first	first	JJ
cord-332422-s15o0hie	206	15	extracellular	extracellular	JJ
cord-332422-s15o0hie	206	16	loop	loop	NN
cord-332422-s15o0hie	206	17	of	of	IN
cord-332422-s15o0hie	206	18	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	206	19	that	that	WDT
cord-332422-s15o0hie	206	20	prevent	prevent	VBP
cord-332422-s15o0hie	206	21	HCV	HCV	NNP
cord-332422-s15o0hie	206	22	entry	entry	NN
cord-332422-s15o0hie	206	23	also	also	RB
cord-332422-s15o0hie	206	24	abolish	abolish	VB
cord-332422-s15o0hie	206	25	CLDN1-CD81	cldn1-cd81	CD
cord-332422-s15o0hie	206	26	interaction	interaction	NN
cord-332422-s15o0hie	206	27	[	[	-LRB-
cord-332422-s15o0hie	206	28	62	62	CD
cord-332422-s15o0hie	206	29	]	]	-RRB-
cord-332422-s15o0hie	206	30	.	.	.
cord-332422-s15o0hie	207	1	Furthermore	furthermore	RB
cord-332422-s15o0hie	207	2	,	,	,
cord-332422-s15o0hie	207	3	antibodies	antibody	NNS
cord-332422-s15o0hie	207	4	directed	direct	VBN
cord-332422-s15o0hie	207	5	against	against	IN
cord-332422-s15o0hie	207	6	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	207	7	or	or	CC
cord-332422-s15o0hie	207	8	CD81	CD81	NNP
cord-332422-s15o0hie	207	9	,	,	,
cord-332422-s15o0hie	207	10	inhibit	inhibit	VB
cord-332422-s15o0hie	207	11	HCV	HCV	NNP
cord-332422-s15o0hie	207	12	entry	entry	NN
cord-332422-s15o0hie	207	13	by	by	IN
cord-332422-s15o0hie	207	14	perturbing	perturb	VBG
cord-332422-s15o0hie	207	15	CLDN1-CD81	CLDN1-CD81	NNP
cord-332422-s15o0hie	207	16	interaction	interaction	NN
cord-332422-s15o0hie	207	17	[	[	-LRB-
cord-332422-s15o0hie	207	18	62	62	CD
cord-332422-s15o0hie	207	19	,	,	,
cord-332422-s15o0hie	207	20	63	63	CD
cord-332422-s15o0hie	207	21	]	]	-RRB-
cord-332422-s15o0hie	207	22	.	.	.
cord-332422-s15o0hie	208	1	Recently	recently	RB
cord-332422-s15o0hie	208	2	,	,	,
cord-332422-s15o0hie	208	3	it	-PRON-	PRP
cord-332422-s15o0hie	208	4	has	have	VBZ
cord-332422-s15o0hie	208	5	also	also	RB
cord-332422-s15o0hie	208	6	been	be	VBN
cord-332422-s15o0hie	208	7	shown	show	VBN
cord-332422-s15o0hie	208	8	that	that	IN
cord-332422-s15o0hie	208	9	epidermal	epidermal	JJ
cord-332422-s15o0hie	208	10	growth	growth	NN
cord-332422-s15o0hie	208	11	factor	factor	NN
cord-332422-s15o0hie	208	12	receptor	receptor	NN
cord-332422-s15o0hie	208	13	and	and	CC
cord-332422-s15o0hie	208	14	ephrin	ephrin	NNP
cord-332422-s15o0hie	208	15	receptor	receptor	NNP
cord-332422-s15o0hie	208	16	A2	A2	NNP
cord-332422-s15o0hie	208	17	act	act	NNP
cord-332422-s15o0hie	208	18	as	as	IN
cord-332422-s15o0hie	208	19	host	host	NN
cord-332422-s15o0hie	208	20	cofactors	cofactor	NNS
cord-332422-s15o0hie	208	21	for	for	IN
cord-332422-s15o0hie	208	22	HCV	HCV	NNP
cord-332422-s15o0hie	208	23	entry	entry	NN
cord-332422-s15o0hie	208	24	by	by	IN
cord-332422-s15o0hie	208	25	regulating	regulate	VBG
cord-332422-s15o0hie	208	26	CLDN1-CD81	CLDN1-CD81	NNP
cord-332422-s15o0hie	208	27	co	co	NN
cord-332422-s15o0hie	208	28	-	-	JJ
cord-332422-s15o0hie	208	29	receptor	receptor	JJ
cord-332422-s15o0hie	208	30	association	association	NN
cord-332422-s15o0hie	208	31	[	[	-LRB-
cord-332422-s15o0hie	208	32	64	64	CD
cord-332422-s15o0hie	208	33	]	]	-RRB-
cord-332422-s15o0hie	208	34	.	.	.
cord-332422-s15o0hie	209	1	Analysis	analysis	NN
cord-332422-s15o0hie	209	2	of	of	IN
cord-332422-s15o0hie	209	3	CLDN1-CD81	CLDN1-CD81	NNP
cord-332422-s15o0hie	209	4	interaction	interaction	NN
cord-332422-s15o0hie	209	5	by	by	IN
cord-332422-s15o0hie	209	6	surface	surface	NN
cord-332422-s15o0hie	209	7	plasmon	plasmon	NNP
cord-332422-s15o0hie	209	8	resonance	resonance	NN
cord-332422-s15o0hie	209	9	demonstrated	demonstrate	VBD
cord-332422-s15o0hie	209	10	a	a	DT
cord-332422-s15o0hie	209	11	specific	specific	JJ
cord-332422-s15o0hie	209	12	interaction	interaction	NN
cord-332422-s15o0hie	209	13	between	between	IN
cord-332422-s15o0hie	209	14	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	209	15	EC1	EC1	NNP
cord-332422-s15o0hie	209	16	and	and	CC
cord-332422-s15o0hie	209	17	CD81	CD81	NNP
cord-332422-s15o0hie	209	18	LEL	LEL	NNP
cord-332422-s15o0hie	209	19	[	[	-LRB-
cord-332422-s15o0hie	209	20	62	62	CD
cord-332422-s15o0hie	209	21	]	]	-RRB-
cord-332422-s15o0hie	209	22	.	.	.
cord-332422-s15o0hie	210	1	Finally	finally	RB
cord-332422-s15o0hie	210	2	,	,	,
cord-332422-s15o0hie	210	3	in	in	IN
cord-332422-s15o0hie	210	4	polarized	polarized	JJ
cord-332422-s15o0hie	210	5	HepG2	HepG2	NNP
cord-332422-s15o0hie	210	6	cells	cell	NNS
cord-332422-s15o0hie	210	7	,	,	,
cord-332422-s15o0hie	210	8	CD81	CD81	NNP
cord-332422-s15o0hie	210	9	and	and	CC
cord-332422-s15o0hie	210	10	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	210	11	association	association	NN
cord-332422-s15o0hie	210	12	occurs	occur	VBZ
cord-332422-s15o0hie	210	13	at	at	IN
cord-332422-s15o0hie	210	14	the	the	DT
cord-332422-s15o0hie	210	15	basolateral	basolateral	JJ
cord-332422-s15o0hie	210	16	domain	domain	NN
cord-332422-s15o0hie	210	17	of	of	IN
cord-332422-s15o0hie	210	18	the	the	DT
cord-332422-s15o0hie	210	19	cells	cell	NNS
cord-332422-s15o0hie	210	20	in	in	IN
cord-332422-s15o0hie	210	21	accordance	accordance	NN
cord-332422-s15o0hie	210	22	with	with	IN
cord-332422-s15o0hie	210	23	the	the	DT
cord-332422-s15o0hie	210	24	virus	virus	NN
cord-332422-s15o0hie	210	25	coming	come	VBG
cord-332422-s15o0hie	210	26	in	in	IN
cord-332422-s15o0hie	210	27	contact	contact	NN
cord-332422-s15o0hie	210	28	with	with	IN
cord-332422-s15o0hie	210	29	the	the	DT
cord-332422-s15o0hie	210	30	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	210	31	at	at	IN
cord-332422-s15o0hie	210	32	the	the	DT
cord-332422-s15o0hie	210	33	sinusoidal	sinusoidal	JJ
cord-332422-s15o0hie	210	34	surface	surface	NN
cord-332422-s15o0hie	210	35	of	of	IN
cord-332422-s15o0hie	210	36	the	the	DT
cord-332422-s15o0hie	210	37	cells	cell	NNS
cord-332422-s15o0hie	210	38	[	[	-LRB-
cord-332422-s15o0hie	210	39	62	62	CD
cord-332422-s15o0hie	210	40	]	]	-RRB-
cord-332422-s15o0hie	210	41	.	.	.
cord-332422-s15o0hie	211	1	Although	although	IN
cord-332422-s15o0hie	211	2	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	211	3	also	also	RB
cord-332422-s15o0hie	211	4	interacts	interact	VBZ
cord-332422-s15o0hie	211	5	with	with	IN
cord-332422-s15o0hie	211	6	OCLN	OCLN	NNP
cord-332422-s15o0hie	211	7	,	,	,
cord-332422-s15o0hie	211	8	there	there	EX
cord-332422-s15o0hie	211	9	is	be	VBZ
cord-332422-s15o0hie	211	10	no	no	DT
cord-332422-s15o0hie	211	11	clear	clear	JJ
cord-332422-s15o0hie	211	12	relationship	relationship	NN
cord-332422-s15o0hie	211	13	between	between	IN
cord-332422-s15o0hie	211	14	CLDN1-OCLN	CLDN1-OCLN	NNP
cord-332422-s15o0hie	211	15	association	association	NNP
cord-332422-s15o0hie	211	16	and	and	CC
cord-332422-s15o0hie	211	17	HCV	HCV	NNP
cord-332422-s15o0hie	211	18	infectivity	infectivity	NN
cord-332422-s15o0hie	211	19	[	[	-LRB-
cord-332422-s15o0hie	211	20	62	62	CD
cord-332422-s15o0hie	211	21	]	]	-RRB-
cord-332422-s15o0hie	211	22	.	.	.
cord-332422-s15o0hie	212	1	After	after	IN
cord-332422-s15o0hie	212	2	initial	initial	JJ
cord-332422-s15o0hie	212	3	binding	binding	NN
cord-332422-s15o0hie	212	4	to	to	IN
cord-332422-s15o0hie	212	5	an	an	DT
cord-332422-s15o0hie	212	6	attachment	attachment	NN
cord-332422-s15o0hie	212	7	factor	factor	NN
cord-332422-s15o0hie	212	8	and	and	CC
cord-332422-s15o0hie	212	9	prior	prior	JJ
cord-332422-s15o0hie	212	10	uptake	uptake	NN
cord-332422-s15o0hie	212	11	,	,	,
cord-332422-s15o0hie	212	12	viruses	virus	NNS
cord-332422-s15o0hie	212	13	move	move	VBP
cord-332422-s15o0hie	212	14	laterally	laterally	RB
cord-332422-s15o0hie	212	15	on	on	IN
cord-332422-s15o0hie	212	16	the	the	DT
cord-332422-s15o0hie	212	17	cell	cell	NN
cord-332422-s15o0hie	212	18	surface	surface	NN
cord-332422-s15o0hie	212	19	.	.	.
cord-332422-s15o0hie	213	1	These	these	DT
cord-332422-s15o0hie	213	2	movements	movement	NNS
cord-332422-s15o0hie	213	3	allow	allow	VBP
cord-332422-s15o0hie	213	4	viruses	virus	NNS
cord-332422-s15o0hie	213	5	to	to	TO
cord-332422-s15o0hie	213	6	interact	interact	VB
cord-332422-s15o0hie	213	7	with	with	IN
cord-332422-s15o0hie	213	8	secondary	secondary	JJ
cord-332422-s15o0hie	213	9	co	co	NN
cord-332422-s15o0hie	213	10	-	-	JJ
cord-332422-s15o0hie	213	11	receptor(s	receptor(s	NNP
cord-332422-s15o0hie	213	12	)	)	-RRB-
cord-332422-s15o0hie	213	13	or	or	CC
cord-332422-s15o0hie	213	14	with	with	IN
cord-332422-s15o0hie	213	15	clathrin	clathrin	NN
cord-332422-s15o0hie	213	16	-	-	HYPH
cord-332422-s15o0hie	213	17	coated	coat	VBN
cord-332422-s15o0hie	213	18	pits	pit	NNS
cord-332422-s15o0hie	213	19	.	.	.
cord-332422-s15o0hie	214	1	Single	single	JJ
cord-332422-s15o0hie	214	2	particle	particle	NN
cord-332422-s15o0hie	214	3	imaging	imaging	NN
cord-332422-s15o0hie	214	4	during	during	IN
cord-332422-s15o0hie	214	5	viral	viral	JJ
cord-332422-s15o0hie	214	6	entry	entry	NN
cord-332422-s15o0hie	214	7	in	in	IN
cord-332422-s15o0hie	214	8	Huh7.5	Huh7.5	NNP
cord-332422-s15o0hie	214	9	cells	cell	NNS
cord-332422-s15o0hie	214	10	has	have	VBZ
cord-332422-s15o0hie	214	11	revealed	reveal	VBN
cord-332422-s15o0hie	214	12	that	that	IN
cord-332422-s15o0hie	214	13	HCV	HCV	NNP
cord-332422-s15o0hie	214	14	particles	particle	NNS
cord-332422-s15o0hie	214	15	bind	bind	VBP
cord-332422-s15o0hie	214	16	cells	cell	NNS
cord-332422-s15o0hie	214	17	on	on	IN
cord-332422-s15o0hie	214	18	filopodia	filopodia	NNS
cord-332422-s15o0hie	214	19	and	and	CC
cord-332422-s15o0hie	214	20	reach	reach	VB
cord-332422-s15o0hie	214	21	the	the	DT
cord-332422-s15o0hie	214	22	cell	cell	NN
cord-332422-s15o0hie	214	23	body	body	NN
cord-332422-s15o0hie	214	24	by	by	IN
cord-332422-s15o0hie	214	25	a	a	DT
cord-332422-s15o0hie	214	26	mechanism	mechanism	NN
cord-332422-s15o0hie	214	27	that	that	WDT
cord-332422-s15o0hie	214	28	relies	rely	VBZ
cord-332422-s15o0hie	214	29	on	on	IN
cord-332422-s15o0hie	214	30	retrograde	retrograde	JJ
cord-332422-s15o0hie	214	31	actin	actin	NN
cord-332422-s15o0hie	214	32	transport	transport	NN
cord-332422-s15o0hie	214	33	[	[	-LRB-
cord-332422-s15o0hie	214	34	65	65	CD
cord-332422-s15o0hie	214	35	]	]	-RRB-
cord-332422-s15o0hie	214	36	.	.	.
cord-332422-s15o0hie	215	1	On	on	IN
cord-332422-s15o0hie	215	2	the	the	DT
cord-332422-s15o0hie	215	3	cell	cell	NN
cord-332422-s15o0hie	215	4	surface	surface	NN
cord-332422-s15o0hie	215	5	,	,	,
cord-332422-s15o0hie	215	6	the	the	DT
cord-332422-s15o0hie	215	7	virion	virion	NN
cord-332422-s15o0hie	215	8	interacts	interact	VBZ
cord-332422-s15o0hie	215	9	with	with	IN
cord-332422-s15o0hie	215	10	a	a	DT
cord-332422-s15o0hie	215	11	receptor	receptor	NN
cord-332422-s15o0hie	215	12	complex	complex	NN
cord-332422-s15o0hie	215	13	and/or	and/or	CC
cord-332422-s15o0hie	215	14	co	co	NNS
cord-332422-s15o0hie	215	15	-	-	NNS
cord-332422-s15o0hie	215	16	receptors	receptor	NNS
cord-332422-s15o0hie	215	17	and	and	CC
cord-332422-s15o0hie	215	18	associates	associate	NNS
cord-332422-s15o0hie	215	19	with	with	IN
cord-332422-s15o0hie	215	20	clathrin	clathrin	NN
cord-332422-s15o0hie	215	21	-	-	HYPH
cord-332422-s15o0hie	215	22	coated	coat	VBN
cord-332422-s15o0hie	215	23	pits	pit	NNS
cord-332422-s15o0hie	215	24	.	.	.
cord-332422-s15o0hie	216	1	It	-PRON-	PRP
cord-332422-s15o0hie	216	2	has	have	VBZ
cord-332422-s15o0hie	216	3	been	be	VBN
cord-332422-s15o0hie	216	4	proposed	propose	VBN
cord-332422-s15o0hie	216	5	that	that	IN
cord-332422-s15o0hie	216	6	CD81	CD81	NNP
cord-332422-s15o0hie	216	7	may	may	MD
cord-332422-s15o0hie	216	8	play	play	VB
cord-332422-s15o0hie	216	9	a	a	DT
cord-332422-s15o0hie	216	10	role	role	NN
cord-332422-s15o0hie	216	11	in	in	IN
cord-332422-s15o0hie	216	12	the	the	DT
cord-332422-s15o0hie	216	13	transport	transport	NN
cord-332422-s15o0hie	216	14	of	of	IN
cord-332422-s15o0hie	216	15	the	the	DT
cord-332422-s15o0hie	216	16	virions	virion	NNS
cord-332422-s15o0hie	216	17	from	from	IN
cord-332422-s15o0hie	216	18	the	the	DT
cord-332422-s15o0hie	216	19	basolateral	basolateral	JJ
cord-332422-s15o0hie	216	20	face	face	NN
cord-332422-s15o0hie	216	21	of	of	IN
cord-332422-s15o0hie	216	22	the	the	DT
cord-332422-s15o0hie	216	23	cells	cell	NNS
cord-332422-s15o0hie	216	24	to	to	IN
cord-332422-s15o0hie	216	25	the	the	DT
cord-332422-s15o0hie	216	26	region	region	NN
cord-332422-s15o0hie	216	27	of	of	IN
cord-332422-s15o0hie	216	28	cell	cell	NN
cord-332422-s15o0hie	216	29	-	-	HYPH
cord-332422-s15o0hie	216	30	cell	cell	NN
cord-332422-s15o0hie	216	31	contact	contact	NN
cord-332422-s15o0hie	216	32	and	and	CC
cord-332422-s15o0hie	216	33	presumably	presumably	RB
cord-332422-s15o0hie	216	34	the	the	DT
cord-332422-s15o0hie	216	35	TJs	tj	NNS
cord-332422-s15o0hie	216	36	where	where	WRB
cord-332422-s15o0hie	216	37	the	the	DT
cord-332422-s15o0hie	216	38	virus	virus	NN
cord-332422-s15o0hie	216	39	could	could	MD
cord-332422-s15o0hie	216	40	then	then	RB
cord-332422-s15o0hie	216	41	interact	interact	VB
cord-332422-s15o0hie	216	42	with	with	IN
cord-332422-s15o0hie	216	43	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	216	44	and	and	CC
cord-332422-s15o0hie	216	45	OCLN	OCLN	NNP
cord-332422-s15o0hie	216	46	[	[	-LRB-
cord-332422-s15o0hie	216	47	66	66	CD
cord-332422-s15o0hie	216	48	]	]	-RRB-
cord-332422-s15o0hie	216	49	.	.	.
cord-332422-s15o0hie	217	1	This	this	DT
cord-332422-s15o0hie	217	2	hypothesis	hypothesis	NN
cord-332422-s15o0hie	217	3	is	be	VBZ
cord-332422-s15o0hie	217	4	based	base	VBN
cord-332422-s15o0hie	217	5	on	on	IN
cord-332422-s15o0hie	217	6	the	the	DT
cord-332422-s15o0hie	217	7	observation	observation	NN
cord-332422-s15o0hie	217	8	that	that	IN
cord-332422-s15o0hie	217	9	a	a	DT
cord-332422-s15o0hie	217	10	soluble	soluble	JJ
cord-332422-s15o0hie	217	11	form	form	NN
cord-332422-s15o0hie	217	12	of	of	IN
cord-332422-s15o0hie	217	13	E2	E2	NNP
cord-332422-s15o0hie	217	14	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	217	15	is	be	VBZ
cord-332422-s15o0hie	217	16	able	able	JJ
cord-332422-s15o0hie	217	17	to	to	TO
cord-332422-s15o0hie	217	18	induce	induce	VB
cord-332422-s15o0hie	217	19	CD81	CD81	NNP
cord-332422-s15o0hie	217	20	relocation	relocation	NN
cord-332422-s15o0hie	217	21	in	in	IN
cord-332422-s15o0hie	217	22	Huh-7	Huh-7	NNP
cord-332422-s15o0hie	217	23	cells	cell	NNS
cord-332422-s15o0hie	217	24	to	to	IN
cord-332422-s15o0hie	217	25	the	the	DT
cord-332422-s15o0hie	217	26	cell	cell	NN
cord-332422-s15o0hie	217	27	-	-	HYPH
cord-332422-s15o0hie	217	28	cell	cell	NN
cord-332422-s15o0hie	217	29	contact	contact	NN
cord-332422-s15o0hie	217	30	areas	area	NNS
cord-332422-s15o0hie	217	31	where	where	WRB
cord-332422-s15o0hie	217	32	it	-PRON-	PRP
cord-332422-s15o0hie	217	33	colocalizes	colocalize	VBZ
cord-332422-s15o0hie	217	34	with	with	IN
cord-332422-s15o0hie	217	35	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	217	36	and	and	CC
cord-332422-s15o0hie	217	37	OCLN	OCLN	NNP
cord-332422-s15o0hie	217	38	.	.	.
cord-332422-s15o0hie	218	1	This	this	DT
cord-332422-s15o0hie	218	2	transport	transport	NN
cord-332422-s15o0hie	218	3	step	step	NN
cord-332422-s15o0hie	218	4	involves	involve	VBZ
cord-332422-s15o0hie	218	5	actin	actin	NN
cord-332422-s15o0hie	218	6	cytoskeleton	cytoskeleton	NN
cord-332422-s15o0hie	218	7	remodeling	remodeling	NN
cord-332422-s15o0hie	218	8	and	and	CC
cord-332422-s15o0hie	218	9	Rho	rho	NN
cord-332422-s15o0hie	218	10	-	-	HYPH
cord-332422-s15o0hie	218	11	GTPase	GTPase	NNP
cord-332422-s15o0hie	218	12	activity	activity	NN
cord-332422-s15o0hie	218	13	.	.	.
cord-332422-s15o0hie	219	1	Therefore	therefore	RB
cord-332422-s15o0hie	219	2	,	,	,
cord-332422-s15o0hie	219	3	not	not	RB
cord-332422-s15o0hie	219	4	only	only	RB
cord-332422-s15o0hie	219	5	does	do	VBZ
cord-332422-s15o0hie	219	6	CD81	CD81	NNP
cord-332422-s15o0hie	219	7	mediate	mediate	VB
cord-332422-s15o0hie	219	8	virus	virus	NN
cord-332422-s15o0hie	219	9	binding	binding	NN
cord-332422-s15o0hie	219	10	,	,	,
cord-332422-s15o0hie	219	11	but	but	CC
cord-332422-s15o0hie	219	12	it	-PRON-	PRP
cord-332422-s15o0hie	219	13	also	also	RB
cord-332422-s15o0hie	219	14	triggers	trigger	VBZ
cord-332422-s15o0hie	219	15	activation	activation	NN
cord-332422-s15o0hie	219	16	of	of	IN
cord-332422-s15o0hie	219	17	signaling	signal	VBG
cord-332422-s15o0hie	219	18	pathway(s	pathway(s	JJ
cord-332422-s15o0hie	219	19	)	)	-RRB-
cord-332422-s15o0hie	219	20	likely	likely	RB
cord-332422-s15o0hie	219	21	required	require	VBN
cord-332422-s15o0hie	219	22	during	during	IN
cord-332422-s15o0hie	219	23	the	the	DT
cord-332422-s15o0hie	219	24	virus	virus	NN
cord-332422-s15o0hie	219	25	life	life	NN
cord-332422-s15o0hie	219	26	cycle	cycle	NN
cord-332422-s15o0hie	219	27	.	.	.
cord-332422-s15o0hie	220	1	It	-PRON-	PRP
cord-332422-s15o0hie	220	2	has	have	VBZ
cord-332422-s15o0hie	220	3	been	be	VBN
cord-332422-s15o0hie	220	4	shown	show	VBN
cord-332422-s15o0hie	220	5	that	that	IN
cord-332422-s15o0hie	220	6	HCV	HCV	NNP
cord-332422-s15o0hie	220	7	undergoes	undergo	VBZ
cord-332422-s15o0hie	220	8	clathrinmediated	clathrinmediate	VBN
cord-332422-s15o0hie	220	9	endocytosis	endocytosis	NN
cord-332422-s15o0hie	220	10	and	and	CC
cord-332422-s15o0hie	220	11	fuses	fuse	NNS
cord-332422-s15o0hie	220	12	in	in	IN
cord-332422-s15o0hie	220	13	early	early	JJ
cord-332422-s15o0hie	220	14	endosomes	endosome	NNS
cord-332422-s15o0hie	220	15	[	[	-LRB-
cord-332422-s15o0hie	220	16	67	67	CD
cord-332422-s15o0hie	220	17	,	,	,
cord-332422-s15o0hie	220	18	68	68	CD
cord-332422-s15o0hie	220	19	]	]	-RRB-
cord-332422-s15o0hie	221	1	(	(	-LRB-
cord-332422-s15o0hie	221	2	Figure	figure	NN
cord-332422-s15o0hie	221	3	2	2	CD
cord-332422-s15o0hie	221	4	)	)	-RRB-
cord-332422-s15o0hie	221	5	.	.	.
cord-332422-s15o0hie	222	1	HCV	HCV	NNP
cord-332422-s15o0hie	222	2	internalization	internalization	NN
cord-332422-s15o0hie	222	3	into	into	IN
cord-332422-s15o0hie	222	4	cells	cell	NNS
cord-332422-s15o0hie	222	5	is	be	VBZ
cord-332422-s15o0hie	222	6	a	a	DT
cord-332422-s15o0hie	222	7	slow	slow	JJ
cord-332422-s15o0hie	222	8	process	process	NN
cord-332422-s15o0hie	222	9	.	.	.
cord-332422-s15o0hie	223	1	The	the	DT
cord-332422-s15o0hie	223	2	half	half	RB
cord-332422-s15o0hie	223	3	-	-	HYPH
cord-332422-s15o0hie	223	4	maximal	maximal	JJ
cord-332422-s15o0hie	223	5	internalization	internalization	NN
cord-332422-s15o0hie	223	6	of	of	IN
cord-332422-s15o0hie	223	7	HCVpp	HCVpp	NNP
cord-332422-s15o0hie	223	8	is	be	VBZ
cord-332422-s15o0hie	223	9	achieved	achieve	VBN
cord-332422-s15o0hie	223	10	in	in	IN
cord-332422-s15o0hie	223	11	approximately	approximately	RB
cord-332422-s15o0hie	223	12	one	one	CD
cord-332422-s15o0hie	223	13	hour	hour	NN
cord-332422-s15o0hie	223	14	.	.	.
cord-332422-s15o0hie	224	1	A	a	DT
cord-332422-s15o0hie	224	2	siRNA	siRNA	NNP
cord-332422-s15o0hie	224	3	library	library	NN
cord-332422-s15o0hie	224	4	screen	screen	NN
cord-332422-s15o0hie	224	5	led	lead	VBD
cord-332422-s15o0hie	224	6	to	to	IN
cord-332422-s15o0hie	224	7	the	the	DT
cord-332422-s15o0hie	224	8	identification	identification	NN
cord-332422-s15o0hie	224	9	of	of	IN
cord-332422-s15o0hie	224	10	host	host	NN
cord-332422-s15o0hie	224	11	cofactors	cofactor	NNS
cord-332422-s15o0hie	224	12	involved	involve	VBN
cord-332422-s15o0hie	224	13	in	in	IN
cord-332422-s15o0hie	224	14	HCV	HCV	NNP
cord-332422-s15o0hie	224	15	entry	entry	NN
cord-332422-s15o0hie	224	16	[	[	-LRB-
cord-332422-s15o0hie	224	17	65	65	CD
cord-332422-s15o0hie	224	18	]	]	-RRB-
cord-332422-s15o0hie	224	19	.	.	.
cord-332422-s15o0hie	225	1	These	these	DT
cord-332422-s15o0hie	225	2	proteins	protein	NNS
cord-332422-s15o0hie	225	3	required	require	VBN
cord-332422-s15o0hie	225	4	for	for	IN
cord-332422-s15o0hie	225	5	HCV	HCV	NNP
cord-332422-s15o0hie	225	6	infection	infection	NN
cord-332422-s15o0hie	225	7	are	be	VBP
cord-332422-s15o0hie	225	8	involved	involve	VBN
cord-332422-s15o0hie	225	9	in	in	IN
cord-332422-s15o0hie	225	10	clathrin	clathrin	NN
cord-332422-s15o0hie	225	11	-	-	HYPH
cord-332422-s15o0hie	225	12	mediated	mediate	VBN
cord-332422-s15o0hie	225	13	endocytosis	endocytosis	NN
cord-332422-s15o0hie	225	14	as	as	RB
cord-332422-s15o0hie	225	15	well	well	RB
cord-332422-s15o0hie	225	16	as	as	IN
cord-332422-s15o0hie	225	17	in	in	IN
cord-332422-s15o0hie	225	18	actin	actin	NN
cord-332422-s15o0hie	225	19	cytoskeleton	cytoskeleton	NN
cord-332422-s15o0hie	225	20	dynamics	dynamic	NNS
cord-332422-s15o0hie	225	21	or	or	CC
cord-332422-s15o0hie	225	22	endosomal	endosomal	NNP
cord-332422-s15o0hie	225	23	trafficking	trafficking	NN
cord-332422-s15o0hie	225	24	and	and	CC
cord-332422-s15o0hie	225	25	acidification	acidification	NN
cord-332422-s15o0hie	225	26	.	.	.
cord-332422-s15o0hie	226	1	In	in	IN
cord-332422-s15o0hie	226	2	single	single	JJ
cord-332422-s15o0hie	226	3	particle	particle	NN
cord-332422-s15o0hie	226	4	tracking	tracking	NN
cord-332422-s15o0hie	226	5	experiments	experiment	NNS
cord-332422-s15o0hie	226	6	,	,	,
cord-332422-s15o0hie	226	7	after	after	IN
cord-332422-s15o0hie	226	8	surfing	surf	VBG
cord-332422-s15o0hie	226	9	on	on	IN
cord-332422-s15o0hie	226	10	the	the	DT
cord-332422-s15o0hie	226	11	cell	cell	NN
cord-332422-s15o0hie	226	12	surface	surface	NN
cord-332422-s15o0hie	226	13	,	,	,
cord-332422-s15o0hie	226	14	virions	virion	NNS
cord-332422-s15o0hie	226	15	colocalized	colocalize	VBN
cord-332422-s15o0hie	226	16	with	with	IN
cord-332422-s15o0hie	226	17	clathrin	clathrin	NN
cord-332422-s15o0hie	226	18	and	and	CC
cord-332422-s15o0hie	226	19	the	the	DT
cord-332422-s15o0hie	226	20	E3	e3	NN
cord-332422-s15o0hie	226	21	ubiquitin	ubiquitin	NN
cord-332422-s15o0hie	226	22	ligase	ligase	NN
cord-332422-s15o0hie	226	23	,	,	,
cord-332422-s15o0hie	226	24	c	c	NN
cord-332422-s15o0hie	226	25	-	-	:
cord-332422-s15o0hie	226	26	Cbl	Cbl	NNP
cord-332422-s15o0hie	226	27	[	[	-LRB-
cord-332422-s15o0hie	226	28	65	65	CD
cord-332422-s15o0hie	226	29	]	]	-RRB-
cord-332422-s15o0hie	226	30	.	.	.
cord-332422-s15o0hie	227	1	The	the	DT
cord-332422-s15o0hie	227	2	exact	exact	JJ
cord-332422-s15o0hie	227	3	role	role	NN
cord-332422-s15o0hie	227	4	of	of	IN
cord-332422-s15o0hie	227	5	c	c	NN
cord-332422-s15o0hie	227	6	-	-	:
cord-332422-s15o0hie	227	7	Cbl	Cbl	NNP
cord-332422-s15o0hie	227	8	in	in	IN
cord-332422-s15o0hie	227	9	HCV	HCV	NNP
cord-332422-s15o0hie	227	10	entry	entry	NN
cord-332422-s15o0hie	227	11	remains	remain	VBZ
cord-332422-s15o0hie	227	12	to	to	TO
cord-332422-s15o0hie	227	13	be	be	VB
cord-332422-s15o0hie	227	14	elucidated	elucidate	VBN
cord-332422-s15o0hie	227	15	yet	yet	RB
cord-332422-s15o0hie	228	1	a	a	DT
cord-332422-s15o0hie	228	2	role	role	NN
cord-332422-s15o0hie	228	3	of	of	IN
cord-332422-s15o0hie	228	4	this	this	DT
cord-332422-s15o0hie	228	5	protein	protein	NN
cord-332422-s15o0hie	228	6	in	in	IN
cord-332422-s15o0hie	228	7	clathrin	clathrin	NN
cord-332422-s15o0hie	228	8	-	-	HYPH
cord-332422-s15o0hie	228	9	mediated	mediate	VBN
cord-332422-s15o0hie	228	10	endocytosis	endocytosis	NN
cord-332422-s15o0hie	228	11	has	have	VBZ
cord-332422-s15o0hie	228	12	already	already	RB
cord-332422-s15o0hie	228	13	been	be	VBN
cord-332422-s15o0hie	228	14	shown	show	VBN
cord-332422-s15o0hie	228	15	for	for	IN
cord-332422-s15o0hie	228	16	the	the	DT
cord-332422-s15o0hie	228	17	bacteria	bacteria	NNS
cord-332422-s15o0hie	228	18	Listeria	Listeria	NNP
cord-332422-s15o0hie	228	19	monocytogenes	monocytogene	NNS
cord-332422-s15o0hie	228	20	[	[	-LRB-
cord-332422-s15o0hie	228	21	69	69	CD
cord-332422-s15o0hie	228	22	]	]	-RRB-
cord-332422-s15o0hie	228	23	.	.	.
cord-332422-s15o0hie	229	1	After	after	IN
cord-332422-s15o0hie	229	2	internalization	internalization	NN
cord-332422-s15o0hie	229	3	,	,	,
cord-332422-s15o0hie	229	4	the	the	DT
cord-332422-s15o0hie	229	5	virus	virus	NN
cord-332422-s15o0hie	229	6	has	have	VBZ
cord-332422-s15o0hie	229	7	been	be	VBN
cord-332422-s15o0hie	229	8	shown	show	VBN
cord-332422-s15o0hie	229	9	to	to	TO
cord-332422-s15o0hie	229	10	be	be	VB
cord-332422-s15o0hie	229	11	transported	transport	VBN
cord-332422-s15o0hie	229	12	to	to	IN
cord-332422-s15o0hie	229	13	GFP	GFP	NNP
cord-332422-s15o0hie	229	14	-	-	HYPH
cord-332422-s15o0hie	229	15	Rab5a	Rab5a	NNP
cord-332422-s15o0hie	229	16	positive	positive	JJ
cord-332422-s15o0hie	229	17	early	early	JJ
cord-332422-s15o0hie	229	18	endosomes	endosome	NNS
cord-332422-s15o0hie	229	19	along	along	IN
cord-332422-s15o0hie	229	20	actin	actin	NN
cord-332422-s15o0hie	229	21	stress	stress	NN
cord-332422-s15o0hie	229	22	fibers	fiber	NNS
cord-332422-s15o0hie	229	23	[	[	-LRB-
cord-332422-s15o0hie	229	24	65	65	CD
cord-332422-s15o0hie	229	25	]	]	-RRB-
cord-332422-s15o0hie	229	26	.	.	.
cord-332422-s15o0hie	230	1	The	the	DT
cord-332422-s15o0hie	230	2	role	role	NN
cord-332422-s15o0hie	230	3	of	of	IN
cord-332422-s15o0hie	230	4	microtubules	microtubule	NNS
cord-332422-s15o0hie	230	5	in	in	IN
cord-332422-s15o0hie	230	6	HCV	HCV	NNP
cord-332422-s15o0hie	230	7	infection	infection	NN
cord-332422-s15o0hie	230	8	has	have	VBZ
cord-332422-s15o0hie	230	9	also	also	RB
cord-332422-s15o0hie	230	10	been	be	VBN
cord-332422-s15o0hie	230	11	investigated	investigate	VBN
cord-332422-s15o0hie	230	12	[	[	-LRB-
cord-332422-s15o0hie	230	13	39	39	CD
cord-332422-s15o0hie	230	14	]	]	-RRB-
cord-332422-s15o0hie	230	15	using	use	VBG
cord-332422-s15o0hie	230	16	pharmacological	pharmacological	JJ
cord-332422-s15o0hie	230	17	agents	agent	NNS
cord-332422-s15o0hie	230	18	that	that	WDT
cord-332422-s15o0hie	230	19	are	be	VBP
cord-332422-s15o0hie	230	20	known	know	VBN
cord-332422-s15o0hie	230	21	to	to	TO
cord-332422-s15o0hie	230	22	affect	affect	VB
cord-332422-s15o0hie	230	23	microtubules	microtubule	NNS
cord-332422-s15o0hie	230	24	such	such	JJ
cord-332422-s15o0hie	230	25	as	as	IN
cord-332422-s15o0hie	230	26	vinblastin	vinblastin	NNP
cord-332422-s15o0hie	230	27	,	,	,
cord-332422-s15o0hie	230	28	nocodazol	nocodazol	NNP
cord-332422-s15o0hie	230	29	or	or	CC
cord-332422-s15o0hie	230	30	paclitaxel	paclitaxel	RB
cord-332422-s15o0hie	230	31	inhibit	inhibit	VBP
cord-332422-s15o0hie	230	32	HCV	HCV	NNP
cord-332422-s15o0hie	230	33	infection	infection	NN
cord-332422-s15o0hie	230	34	.	.	.
cord-332422-s15o0hie	231	1	These	these	DT
cord-332422-s15o0hie	231	2	molecules	molecule	NNS
cord-332422-s15o0hie	231	3	affect	affect	VBP
cord-332422-s15o0hie	231	4	HCV	HCV	NNP
cord-332422-s15o0hie	231	5	entry	entry	NN
cord-332422-s15o0hie	231	6	as	as	RB
cord-332422-s15o0hie	231	7	well	well	RB
cord-332422-s15o0hie	231	8	as	as	IN
cord-332422-s15o0hie	231	9	an	an	DT
cord-332422-s15o0hie	231	10	early	early	JJ
cord-332422-s15o0hie	231	11	post	post	JJ
cord-332422-s15o0hie	231	12	-	-	JJ
cord-332422-s15o0hie	231	13	fusion	fusion	JJ
cord-332422-s15o0hie	231	14	step	step	NN
cord-332422-s15o0hie	231	15	.	.	.
cord-332422-s15o0hie	232	1	Generally	generally	RB
cord-332422-s15o0hie	232	2	,	,	,
cord-332422-s15o0hie	232	3	virus	virus	NN
cord-332422-s15o0hie	232	4	endocytosis	endocytosis	NN
cord-332422-s15o0hie	232	5	is	be	VBZ
cord-332422-s15o0hie	232	6	mediated	mediate	VBN
cord-332422-s15o0hie	232	7	by	by	IN
cord-332422-s15o0hie	232	8	receptor(s	receptor(s	NNP
cord-332422-s15o0hie	232	9	)	)	-RRB-
cord-332422-s15o0hie	232	10	.	.	.
cord-332422-s15o0hie	233	1	However	however	RB
cord-332422-s15o0hie	233	2	,	,	,
cord-332422-s15o0hie	233	3	to	to	IN
cord-332422-s15o0hie	233	4	date	date	NN
cord-332422-s15o0hie	233	5	,	,	,
cord-332422-s15o0hie	233	6	the	the	DT
cord-332422-s15o0hie	233	7	exact	exact	JJ
cord-332422-s15o0hie	233	8	role	role	NN
cord-332422-s15o0hie	233	9	of	of	IN
cord-332422-s15o0hie	233	10	HCV	HCV	NNP
cord-332422-s15o0hie	233	11	co	co	NNS
cord-332422-s15o0hie	233	12	-	-	NNS
cord-332422-s15o0hie	233	13	receptors	receptor	NNS
cord-332422-s15o0hie	233	14	in	in	IN
cord-332422-s15o0hie	233	15	endocytosis	endocytosis	NN
cord-332422-s15o0hie	233	16	of	of	IN
cord-332422-s15o0hie	233	17	the	the	DT
cord-332422-s15o0hie	233	18	virus	virus	NN
cord-332422-s15o0hie	233	19	remains	remain	VBZ
cord-332422-s15o0hie	233	20	undetermined	undetermined	JJ
cord-332422-s15o0hie	233	21	.	.	.
cord-332422-s15o0hie	234	1	Due	due	IN
cord-332422-s15o0hie	234	2	to	to	IN
cord-332422-s15o0hie	234	3	the	the	DT
cord-332422-s15o0hie	234	4	lack	lack	NN
cord-332422-s15o0hie	234	5	of	of	IN
cord-332422-s15o0hie	234	6	a	a	DT
cord-332422-s15o0hie	234	7	robust	robust	JJ
cord-332422-s15o0hie	234	8	polarized	polarized	JJ
cord-332422-s15o0hie	234	9	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	234	10	in	in	IN
cord-332422-s15o0hie	234	11	vitro	vitro	FW
cord-332422-s15o0hie	234	12	model	model	NN
cord-332422-s15o0hie	234	13	that	that	WDT
cord-332422-s15o0hie	234	14	supports	support	VBZ
cord-332422-s15o0hie	234	15	HCV	HCV	NNP
cord-332422-s15o0hie	234	16	replication	replication	NN
cord-332422-s15o0hie	234	17	,	,	,
cord-332422-s15o0hie	234	18	the	the	DT
cord-332422-s15o0hie	234	19	role	role	NN
cord-332422-s15o0hie	234	20	of	of	IN
cord-332422-s15o0hie	234	21	TJ	TJ	NNP
cord-332422-s15o0hie	234	22	formation	formation	NN
cord-332422-s15o0hie	234	23	in	in	IN
cord-332422-s15o0hie	234	24	HCV	HCV	NNP
cord-332422-s15o0hie	234	25	entry	entry	NN
cord-332422-s15o0hie	234	26	remains	remain	VBZ
cord-332422-s15o0hie	234	27	unclear	unclear	JJ
cord-332422-s15o0hie	234	28	.	.	.
cord-332422-s15o0hie	235	1	In	in	IN
cord-332422-s15o0hie	235	2	vivo	vivo	NN
cord-332422-s15o0hie	235	3	,	,	,
cord-332422-s15o0hie	235	4	OCLN	OCLN	NNP
cord-332422-s15o0hie	235	5	and	and	CC
cord-332422-s15o0hie	235	6	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	235	7	are	be	VBP
cord-332422-s15o0hie	235	8	concentrated	concentrate	VBN
cord-332422-s15o0hie	235	9	in	in	IN
cord-332422-s15o0hie	235	10	TJs	TJs	NNP
cord-332422-s15o0hie	235	11	,	,	,
cord-332422-s15o0hie	235	12	whereas	whereas	IN
cord-332422-s15o0hie	235	13	CLDN	CLDN	NNP
cord-332422-s15o0hie	235	14	is	be	VBZ
cord-332422-s15o0hie	235	15	also	also	RB
cord-332422-s15o0hie	235	16	detected	detect	VBN
cord-332422-s15o0hie	235	17	at	at	IN
cord-332422-s15o0hie	235	18	the	the	DT
cord-332422-s15o0hie	235	19	basolateral	basolateral	JJ
cord-332422-s15o0hie	235	20	face	face	NN
cord-332422-s15o0hie	235	21	in	in	IN
cord-332422-s15o0hie	235	22	polarized	polarized	JJ
cord-332422-s15o0hie	235	23	HepG2	HepG2	NNP
cord-332422-s15o0hie	235	24	cells	cell	NNS
cord-332422-s15o0hie	235	25	or	or	CC
cord-332422-s15o0hie	235	26	in	in	IN
cord-332422-s15o0hie	235	27	liver	liver	NN
cord-332422-s15o0hie	235	28	tissue	tissue	NN
cord-332422-s15o0hie	235	29	.	.	.
cord-332422-s15o0hie	236	1	Though	though	IN
cord-332422-s15o0hie	236	2	the	the	DT
cord-332422-s15o0hie	236	3	virus	virus	NN
cord-332422-s15o0hie	236	4	is	be	VBZ
cord-332422-s15o0hie	236	5	probably	probably	RB
cord-332422-s15o0hie	236	6	internalized	internalize	VBN
cord-332422-s15o0hie	236	7	in	in	IN
cord-332422-s15o0hie	236	8	the	the	DT
cord-332422-s15o0hie	236	9	TJ	TJ	NNP
cord-332422-s15o0hie	236	10	area	area	NN
cord-332422-s15o0hie	236	11	in	in	IN
cord-332422-s15o0hie	236	12	vivo	vivo	NN
cord-332422-s15o0hie	236	13	,	,	,
cord-332422-s15o0hie	236	14	formation	formation	NN
cord-332422-s15o0hie	236	15	of	of	IN
cord-332422-s15o0hie	236	16	TJs	TJs	NNP
cord-332422-s15o0hie	236	17	is	be	VBZ
cord-332422-s15o0hie	236	18	dispensable	dispensable	JJ
cord-332422-s15o0hie	236	19	for	for	IN
cord-332422-s15o0hie	236	20	HCV	HCV	NNP
cord-332422-s15o0hie	236	21	entry	entry	NN
cord-332422-s15o0hie	236	22	in	in	IN
cord-332422-s15o0hie	236	23	cell	cell	NN
cord-332422-s15o0hie	236	24	culture	culture	NN
cord-332422-s15o0hie	236	25	.	.	.
cord-332422-s15o0hie	237	1	Some	some	DT
cord-332422-s15o0hie	237	2	data	datum	NNS
cord-332422-s15o0hie	237	3	suggest	suggest	VBP
cord-332422-s15o0hie	237	4	that	that	IN
cord-332422-s15o0hie	237	5	the	the	DT
cord-332422-s15o0hie	237	6	non	non	JJ
cord-332422-s15o0hie	237	7	-	-	JJ
cord-332422-s15o0hie	237	8	junctional	junctional	JJ
cord-332422-s15o0hie	237	9	pool	pool	NN
cord-332422-s15o0hie	237	10	of	of	IN
cord-332422-s15o0hie	237	11	CLDN1	cldn1	NN
cord-332422-s15o0hie	237	12	is	be	VBZ
cord-332422-s15o0hie	237	13	involved	involve	VBN
cord-332422-s15o0hie	237	14	in	in	IN
cord-332422-s15o0hie	237	15	HCV	HCV	NNP
cord-332422-s15o0hie	237	16	entry	entry	NN
cord-332422-s15o0hie	237	17	[	[	-LRB-
cord-332422-s15o0hie	237	18	70	70	CD
cord-332422-s15o0hie	237	19	,	,	,
cord-332422-s15o0hie	237	20	71	71	CD
cord-332422-s15o0hie	237	21	]	]	-RRB-
cord-332422-s15o0hie	237	22	,	,	,
cord-332422-s15o0hie	237	23	whereas	whereas	IN
cord-332422-s15o0hie	237	24	others	other	NNS
cord-332422-s15o0hie	237	25	have	have	VBP
cord-332422-s15o0hie	237	26	shown	show	VBN
cord-332422-s15o0hie	237	27	that	that	IN
cord-332422-s15o0hie	237	28	CLDN1	cldn1	NN
cord-332422-s15o0hie	237	29	localization	localization	NN
cord-332422-s15o0hie	237	30	at	at	IN
cord-332422-s15o0hie	237	31	cell	cell	NN
cord-332422-s15o0hie	237	32	-	-	HYPH
cord-332422-s15o0hie	237	33	cell	cell	NN
cord-332422-s15o0hie	237	34	contacts	contact	NNS
cord-332422-s15o0hie	237	35	is	be	VBZ
cord-332422-s15o0hie	237	36	required	require	VBN
cord-332422-s15o0hie	237	37	for	for	IN
cord-332422-s15o0hie	237	38	HCV	HCV	NNP
cord-332422-s15o0hie	237	39	infection	infection	NN
cord-332422-s15o0hie	237	40	.	.	.
cord-332422-s15o0hie	238	1	In	in	IN
cord-332422-s15o0hie	238	2	addition	addition	NN
cord-332422-s15o0hie	238	3	,	,	,
cord-332422-s15o0hie	238	4	it	-PRON-	PRP
cord-332422-s15o0hie	238	5	has	have	VBZ
cord-332422-s15o0hie	238	6	been	be	VBN
cord-332422-s15o0hie	238	7	shown	show	VBN
cord-332422-s15o0hie	238	8	that	that	IN
cord-332422-s15o0hie	238	9	,	,	,
cord-332422-s15o0hie	238	10	in	in	IN
cord-332422-s15o0hie	238	11	non	non	JJ
cord-332422-s15o0hie	238	12	-	-	JJ
cord-332422-s15o0hie	238	13	polarized	polarized	JJ
cord-332422-s15o0hie	238	14	Huh7.5	Huh7.5	NNP
cord-332422-s15o0hie	238	15	cells	cell	NNS
cord-332422-s15o0hie	238	16	,	,	,
cord-332422-s15o0hie	238	17	cell	cell	NN
cord-332422-s15o0hie	238	18	density	density	NN
cord-332422-s15o0hie	238	19	and	and	CC
cord-332422-s15o0hie	238	20	formation	formation	NN
cord-332422-s15o0hie	238	21	of	of	IN
cord-332422-s15o0hie	238	22	cell	cell	NN
cord-332422-s15o0hie	238	23	-	-	HYPH
cord-332422-s15o0hie	238	24	cell	cell	NN
cord-332422-s15o0hie	238	25	contacts	contact	NNS
cord-332422-s15o0hie	238	26	modulate	modulate	VBP
cord-332422-s15o0hie	238	27	receptor	receptor	NN
cord-332422-s15o0hie	238	28	expression	expression	NN
cord-332422-s15o0hie	238	29	and	and	CC
cord-332422-s15o0hie	238	30	HCV	HCV	NNP
cord-332422-s15o0hie	238	31	infection	infection	NN
cord-332422-s15o0hie	238	32	[	[	-LRB-
cord-332422-s15o0hie	238	33	72	72	CD
cord-332422-s15o0hie	238	34	]	]	-RRB-
cord-332422-s15o0hie	238	35	.	.	.
cord-332422-s15o0hie	239	1	More	more	RBR
cord-332422-s15o0hie	239	2	precisely	precisely	RB
cord-332422-s15o0hie	239	3	,	,	,
cord-332422-s15o0hie	239	4	SRB1	SRB1	NNP
cord-332422-s15o0hie	239	5	and	and	CC
cord-332422-s15o0hie	239	6	CLDN1	cldn1	NN
cord-332422-s15o0hie	239	7	expression	expression	NN
cord-332422-s15o0hie	239	8	is	be	VBZ
cord-332422-s15o0hie	239	9	increased	increase	VBN
cord-332422-s15o0hie	239	10	in	in	IN
cord-332422-s15o0hie	239	11	confluent	confluent	JJ
cord-332422-s15o0hie	239	12	cells	cell	NNS
cord-332422-s15o0hie	239	13	in	in	IN
cord-332422-s15o0hie	239	14	which	which	WDT
cord-332422-s15o0hie	239	15	they	-PRON-	PRP
cord-332422-s15o0hie	239	16	are	be	VBP
cord-332422-s15o0hie	239	17	concentrated	concentrate	VBN
cord-332422-s15o0hie	239	18	at	at	IN
cord-332422-s15o0hie	239	19	cell	cell	NN
cord-332422-s15o0hie	239	20	-	-	HYPH
cord-332422-s15o0hie	239	21	cell	cell	NN
cord-332422-s15o0hie	239	22	contacts	contact	NNS
cord-332422-s15o0hie	239	23	whereas	whereas	IN
cord-332422-s15o0hie	239	24	CD81	CD81	NNP
cord-332422-s15o0hie	239	25	and	and	CC
cord-332422-s15o0hie	239	26	OCLN	ocln	JJ
cord-332422-s15o0hie	239	27	expression	expression	NN
cord-332422-s15o0hie	239	28	levels	level	NNS
cord-332422-s15o0hie	239	29	remain	remain	VBP
cord-332422-s15o0hie	239	30	unaffected	unaffected	JJ
cord-332422-s15o0hie	239	31	by	by	IN
cord-332422-s15o0hie	239	32	cell	cell	NN
cord-332422-s15o0hie	239	33	confluence	confluence	NN
cord-332422-s15o0hie	239	34	.	.	.
cord-332422-s15o0hie	240	1	Interestingly	interestingly	RB
cord-332422-s15o0hie	240	2	,	,	,
cord-332422-s15o0hie	240	3	infection	infection	NN
cord-332422-s15o0hie	240	4	increased	increase	VBD
cord-332422-s15o0hie	240	5	in	in	IN
cord-332422-s15o0hie	240	6	confluent	confluent	JJ
cord-332422-s15o0hie	240	7	cells	cell	NNS
cord-332422-s15o0hie	240	8	compared	compare	VBN
cord-332422-s15o0hie	240	9	to	to	IN
cord-332422-s15o0hie	240	10	subconfluent	subconfluent	NN
cord-332422-s15o0hie	240	11	cells	cell	NNS
cord-332422-s15o0hie	240	12	,	,	,
cord-332422-s15o0hie	240	13	and	and	CC
cord-332422-s15o0hie	240	14	cell	cell	NN
cord-332422-s15o0hie	240	15	-	-	HYPH
cord-332422-s15o0hie	240	16	cell	cell	NN
cord-332422-s15o0hie	240	17	contacts	contact	NNS
cord-332422-s15o0hie	240	18	promoted	promote	VBD
cord-332422-s15o0hie	240	19	virus	virus	NN
cord-332422-s15o0hie	240	20	internalization	internalization	NN
cord-332422-s15o0hie	240	21	.	.	.
cord-332422-s15o0hie	241	1	The	the	DT
cord-332422-s15o0hie	241	2	relevance	relevance	NN
cord-332422-s15o0hie	241	3	of	of	IN
cord-332422-s15o0hie	241	4	cell	cell	NN
cord-332422-s15o0hie	241	5	polarity	polarity	NN
cord-332422-s15o0hie	241	6	to	to	IN
cord-332422-s15o0hie	241	7	HCV	HCV	NNP
cord-332422-s15o0hie	241	8	entry	entry	NN
cord-332422-s15o0hie	241	9	has	have	VBZ
cord-332422-s15o0hie	241	10	only	only	RB
cord-332422-s15o0hie	241	11	been	be	VBN
cord-332422-s15o0hie	241	12	addressed	address	VBN
cord-332422-s15o0hie	241	13	indirectly	indirectly	RB
cord-332422-s15o0hie	241	14	through	through	IN
cord-332422-s15o0hie	241	15	the	the	DT
cord-332422-s15o0hie	241	16	use	use	NN
cord-332422-s15o0hie	241	17	of	of	IN
cord-332422-s15o0hie	241	18	the	the	DT
cord-332422-s15o0hie	241	19	HCVpp	HCVpp	NNP
cord-332422-s15o0hie	241	20	system	system	NN
cord-332422-s15o0hie	241	21	.	.	.
cord-332422-s15o0hie	242	1	In	in	IN
cord-332422-s15o0hie	242	2	HepG2-CD81	HepG2-CD81	NNP
cord-332422-s15o0hie	242	3	cells	cell	NNS
cord-332422-s15o0hie	242	4	,	,	,
cord-332422-s15o0hie	242	5	the	the	DT
cord-332422-s15o0hie	242	6	acquisition	acquisition	NN
cord-332422-s15o0hie	242	7	of	of	IN
cord-332422-s15o0hie	242	8	polarity	polarity	NN
cord-332422-s15o0hie	242	9	correlates	correlate	VBZ
cord-332422-s15o0hie	242	10	with	with	IN
cord-332422-s15o0hie	242	11	a	a	DT
cord-332422-s15o0hie	242	12	reduction	reduction	NN
cord-332422-s15o0hie	242	13	in	in	IN
cord-332422-s15o0hie	242	14	HCVpp	HCVpp	NNP
cord-332422-s15o0hie	242	15	entry	entry	NN
cord-332422-s15o0hie	242	16	.	.	.
cord-332422-s15o0hie	243	1	HCV	HCV	NNP
cord-332422-s15o0hie	243	2	entry	entry	NN
cord-332422-s15o0hie	243	3	has	have	VBZ
cord-332422-s15o0hie	243	4	also	also	RB
cord-332422-s15o0hie	243	5	been	be	VBN
cord-332422-s15o0hie	243	6	studied	study	VBN
cord-332422-s15o0hie	243	7	in	in	IN
cord-332422-s15o0hie	243	8	polarized	polarized	JJ
cord-332422-s15o0hie	243	9	Caco-2	caco-2	NN
cord-332422-s15o0hie	243	10	cells	cell	NNS
cord-332422-s15o0hie	243	11	[	[	-LRB-
cord-332422-s15o0hie	243	12	73	73	CD
cord-332422-s15o0hie	243	13	]	]	-RRB-
cord-332422-s15o0hie	243	14	.	.	.
cord-332422-s15o0hie	244	1	These	these	DT
cord-332422-s15o0hie	244	2	are	be	VBP
cord-332422-s15o0hie	244	3	colorectal	colorectal	JJ
cord-332422-s15o0hie	244	4	adenocarcinoma	adenocarcinoma	NN
cord-332422-s15o0hie	244	5	cells	cell	NNS
cord-332422-s15o0hie	244	6	that	that	WDT
cord-332422-s15o0hie	244	7	form	form	VBP
cord-332422-s15o0hie	244	8	polarized	polarized	JJ
cord-332422-s15o0hie	244	9	monolayers	monolayer	NNS
cord-332422-s15o0hie	244	10	of	of	IN
cord-332422-s15o0hie	244	11	cells	cell	NNS
cord-332422-s15o0hie	244	12	displaying	display	VBG
cord-332422-s15o0hie	244	13	a	a	DT
cord-332422-s15o0hie	244	14	columnar	columnar	JJ
cord-332422-s15o0hie	244	15	morphology	morphology	NN
cord-332422-s15o0hie	244	16	with	with	IN
cord-332422-s15o0hie	244	17	an	an	DT
cord-332422-s15o0hie	244	18	apical	apical	JJ
cord-332422-s15o0hie	244	19	domain	domain	NN
cord-332422-s15o0hie	244	20	and	and	CC
cord-332422-s15o0hie	244	21	a	a	DT
cord-332422-s15o0hie	244	22	basolateral	basolateral	JJ
cord-332422-s15o0hie	244	23	domain	domain	NN
cord-332422-s15o0hie	244	24	.	.	.
cord-332422-s15o0hie	245	1	Caco-2	caco-2	NN
cord-332422-s15o0hie	245	2	cells	cell	NNS
cord-332422-s15o0hie	245	3	are	be	VBP
cord-332422-s15o0hie	245	4	poorly	poorly	RB
cord-332422-s15o0hie	245	5	permissive	permissive	JJ
cord-332422-s15o0hie	245	6	to	to	IN
cord-332422-s15o0hie	245	7	HCVpp	hcvpp	NN
cord-332422-s15o0hie	245	8	and	and	CC
cord-332422-s15o0hie	245	9	infection	infection	NN
cord-332422-s15o0hie	245	10	occurs	occur	VBZ
cord-332422-s15o0hie	245	11	at	at	IN
cord-332422-s15o0hie	245	12	the	the	DT
cord-332422-s15o0hie	245	13	apical	apical	JJ
cord-332422-s15o0hie	245	14	surface	surface	NN
cord-332422-s15o0hie	245	15	of	of	IN
cord-332422-s15o0hie	245	16	the	the	DT
cord-332422-s15o0hie	245	17	cell	cell	NN
cord-332422-s15o0hie	245	18	,	,	,
cord-332422-s15o0hie	245	19	suggesting	suggest	VBG
cord-332422-s15o0hie	245	20	that	that	IN
cord-332422-s15o0hie	245	21	TJs	tj	NNS
cord-332422-s15o0hie	245	22	provide	provide	VB
cord-332422-s15o0hie	245	23	a	a	DT
cord-332422-s15o0hie	245	24	barrier	barrier	NN
cord-332422-s15o0hie	245	25	to	to	IN
cord-332422-s15o0hie	245	26	virus	virus	NN
cord-332422-s15o0hie	245	27	diffusion	diffusion	NN
cord-332422-s15o0hie	245	28	.	.	.
cord-332422-s15o0hie	246	1	In	in	IN
cord-332422-s15o0hie	246	2	these	these	DT
cord-332422-s15o0hie	246	3	cells	cell	NNS
cord-332422-s15o0hie	246	4	,	,	,
cord-332422-s15o0hie	246	5	receptor	receptor	NN
cord-332422-s15o0hie	246	6	expression	expression	NN
cord-332422-s15o0hie	246	7	increased	increase	VBD
cord-332422-s15o0hie	246	8	upon	upon	IN
cord-332422-s15o0hie	246	9	cell	cell	NN
cord-332422-s15o0hie	246	10	polarization	polarization	NN
cord-332422-s15o0hie	246	11	and	and	CC
cord-332422-s15o0hie	246	12	polarization	polarization	NN
cord-332422-s15o0hie	246	13	induced	induce	VBN
cord-332422-s15o0hie	246	14	relocalization	relocalization	NN
cord-332422-s15o0hie	246	15	of	of	IN
cord-332422-s15o0hie	246	16	CLDN1	CLDN1	NNS
cord-332422-s15o0hie	246	17	from	from	IN
cord-332422-s15o0hie	246	18	the	the	DT
cord-332422-s15o0hie	246	19	apical	apical	JJ
cord-332422-s15o0hie	246	20	domain	domain	NN
cord-332422-s15o0hie	246	21	to	to	IN
cord-332422-s15o0hie	246	22	the	the	DT
cord-332422-s15o0hie	246	23	TJs	TJs	NNP
cord-332422-s15o0hie	246	24	and	and	CC
cord-332422-s15o0hie	246	25	the	the	DT
cord-332422-s15o0hie	246	26	basal	basal	NN
cord-332422-s15o0hie	246	27	domain	domain	NN
cord-332422-s15o0hie	246	28	.	.	.
cord-332422-s15o0hie	247	1	Unpolarized	unpolarized	JJ
cord-332422-s15o0hie	247	2	Caco-2	Caco-2	NNP
cord-332422-s15o0hie	247	3	cells	cell	NNS
cord-332422-s15o0hie	247	4	or	or	CC
cord-332422-s15o0hie	247	5	polarized	polarized	JJ
cord-332422-s15o0hie	247	6	cells	cell	NNS
cord-332422-s15o0hie	247	7	are	be	VBP
cord-332422-s15o0hie	247	8	infected	infect	VBN
cord-332422-s15o0hie	247	9	at	at	IN
cord-332422-s15o0hie	247	10	similar	similar	JJ
cord-332422-s15o0hie	247	11	levels	level	NNS
cord-332422-s15o0hie	247	12	,	,	,
cord-332422-s15o0hie	247	13	suggesting	suggest	VBG
cord-332422-s15o0hie	247	14	that	that	IN
cord-332422-s15o0hie	247	15	the	the	DT
cord-332422-s15o0hie	247	16	CLDN1	CLDN1	NNP
cord-332422-s15o0hie	247	17	receptor	receptor	NN
cord-332422-s15o0hie	247	18	function	function	NN
cord-332422-s15o0hie	247	19	is	be	VBZ
cord-332422-s15o0hie	247	20	independent	independent	JJ
cord-332422-s15o0hie	247	21	of	of	IN
cord-332422-s15o0hie	247	22	TJ	TJ	NNP
cord-332422-s15o0hie	247	23	formation	formation	NN
cord-332422-s15o0hie	247	24	.	.	.
cord-332422-s15o0hie	248	1	These	these	DT
cord-332422-s15o0hie	248	2	results	result	NNS
cord-332422-s15o0hie	248	3	suggest	suggest	VBP
cord-332422-s15o0hie	248	4	that	that	IN
cord-332422-s15o0hie	248	5	establishment	establishment	NN
cord-332422-s15o0hie	248	6	of	of	IN
cord-332422-s15o0hie	248	7	cell	cell	NN
cord-332422-s15o0hie	248	8	-	-	HYPH
cord-332422-s15o0hie	248	9	cell	cell	NN
cord-332422-s15o0hie	248	10	contacts	contact	NNS
cord-332422-s15o0hie	248	11	and	and	CC
cord-332422-s15o0hie	248	12	polarity	polarity	NN
cord-332422-s15o0hie	248	13	may	may	MD
cord-332422-s15o0hie	248	14	be	be	VB
cord-332422-s15o0hie	248	15	of	of	IN
cord-332422-s15o0hie	248	16	significance	significance	NN
cord-332422-s15o0hie	248	17	in	in	IN
cord-332422-s15o0hie	248	18	HCV	HCV	NNP
cord-332422-s15o0hie	248	19	entry	entry	NN
cord-332422-s15o0hie	248	20	.	.	.
cord-332422-s15o0hie	249	1	As	as	IN
cord-332422-s15o0hie	249	2	a	a	DT
cord-332422-s15o0hie	249	3	consequence	consequence	NN
cord-332422-s15o0hie	249	4	,	,	,
cord-332422-s15o0hie	249	5	a	a	DT
cord-332422-s15o0hie	249	6	more	more	RBR
cord-332422-s15o0hie	249	7	suitable	suitable	JJ
cord-332422-s15o0hie	249	8	model	model	NN
cord-332422-s15o0hie	249	9	of	of	IN
cord-332422-s15o0hie	249	10	polarized	polarized	JJ
cord-332422-s15o0hie	249	11	hepatoma	hepatoma	NNP
cord-332422-s15o0hie	249	12	cell	cell	NN
cord-332422-s15o0hie	249	13	line	line	NN
cord-332422-s15o0hie	249	14	is	be	VBZ
cord-332422-s15o0hie	249	15	much	much	RB
cord-332422-s15o0hie	249	16	needed	need	VBN
cord-332422-s15o0hie	249	17	to	to	TO
cord-332422-s15o0hie	249	18	study	study	VB
cord-332422-s15o0hie	249	19	HCV	HCV	NNP
cord-332422-s15o0hie	249	20	entry	entry	NN
cord-332422-s15o0hie	249	21	.	.	.
cord-332422-s15o0hie	250	1	Such	such	PDT
cord-332422-s15o0hie	250	2	a	a	DT
cord-332422-s15o0hie	250	3	model	model	NN
cord-332422-s15o0hie	250	4	will	will	MD
cord-332422-s15o0hie	250	5	also	also	RB
cord-332422-s15o0hie	250	6	be	be	VB
cord-332422-s15o0hie	250	7	useful	useful	JJ
cord-332422-s15o0hie	250	8	to	to	TO
cord-332422-s15o0hie	250	9	understand	understand	VB
cord-332422-s15o0hie	250	10	virus	virus	NN
cord-332422-s15o0hie	250	11	spread	spread	VBN
cord-332422-s15o0hie	250	12	in	in	IN
cord-332422-s15o0hie	250	13	the	the	DT
cord-332422-s15o0hie	250	14	liver	liver	NN
cord-332422-s15o0hie	250	15	.	.	.
cord-332422-s15o0hie	251	1	Based	base	VBN
cord-332422-s15o0hie	251	2	on	on	IN
cord-332422-s15o0hie	251	3	observations	observation	NNS
cord-332422-s15o0hie	251	4	of	of	IN
cord-332422-s15o0hie	251	5	HCV	HCV	NNP
cord-332422-s15o0hie	251	6	spread	spread	VBD
cord-332422-s15o0hie	251	7	in	in	IN
cord-332422-s15o0hie	251	8	cell	cell	NN
cord-332422-s15o0hie	251	9	culture	culture	NN
cord-332422-s15o0hie	251	10	in	in	IN
cord-332422-s15o0hie	251	11	the	the	DT
cord-332422-s15o0hie	251	12	presence	presence	NN
cord-332422-s15o0hie	251	13	of	of	IN
cord-332422-s15o0hie	251	14	neutralizing	neutralize	VBG
cord-332422-s15o0hie	251	15	antibodies	antibody	NNS
cord-332422-s15o0hie	251	16	,	,	,
cord-332422-s15o0hie	251	17	a	a	DT
cord-332422-s15o0hie	251	18	mechanism	mechanism	NN
cord-332422-s15o0hie	251	19	of	of	IN
cord-332422-s15o0hie	251	20	direct	direct	JJ
cord-332422-s15o0hie	251	21	cell	cell	NN
cord-332422-s15o0hie	251	22	-	-	HYPH
cord-332422-s15o0hie	251	23	to	to	IN
cord-332422-s15o0hie	251	24	-	-	HYPH
cord-332422-s15o0hie	251	25	cell	cell	NN
cord-332422-s15o0hie	251	26	HCV	HCV	NNP
cord-332422-s15o0hie	251	27	transfer	transfer	NN
cord-332422-s15o0hie	251	28	has	have	VBZ
cord-332422-s15o0hie	251	29	been	be	VBN
cord-332422-s15o0hie	251	30	proposed	propose	VBN
cord-332422-s15o0hie	251	31	[	[	-LRB-
cord-332422-s15o0hie	251	32	74	74	CD
cord-332422-s15o0hie	251	33	]	]	-RRB-
cord-332422-s15o0hie	251	34	[	[	-LRB-
cord-332422-s15o0hie	251	35	75	75	CD
cord-332422-s15o0hie	251	36	]	]	-RRB-
cord-332422-s15o0hie	251	37	[	[	-LRB-
cord-332422-s15o0hie	251	38	76	76	CD
cord-332422-s15o0hie	251	39	]	]	-RRB-
cord-332422-s15o0hie	251	40	[	[	-LRB-
cord-332422-s15o0hie	251	41	77	77	CD
cord-332422-s15o0hie	251	42	]	]	-RRB-
cord-332422-s15o0hie	251	43	.	.	.
cord-332422-s15o0hie	252	1	The	the	DT
cord-332422-s15o0hie	252	2	role	role	NN
cord-332422-s15o0hie	252	3	of	of	IN
cord-332422-s15o0hie	252	4	the	the	DT
cord-332422-s15o0hie	252	5	different	different	JJ
cord-332422-s15o0hie	252	6	HCV	HCV	NNP
cord-332422-s15o0hie	252	7	co	co	NNS
cord-332422-s15o0hie	252	8	-	-	NNS
cord-332422-s15o0hie	252	9	receptors	receptor	NNS
cord-332422-s15o0hie	252	10	in	in	IN
cord-332422-s15o0hie	252	11	this	this	DT
cord-332422-s15o0hie	252	12	transfer	transfer	NN
cord-332422-s15o0hie	252	13	has	have	VBZ
cord-332422-s15o0hie	252	14	been	be	VBN
cord-332422-s15o0hie	252	15	investigated	investigate	VBN
cord-332422-s15o0hie	252	16	.	.	.
cord-332422-s15o0hie	253	1	Both	both	DT
cord-332422-s15o0hie	253	2	TJ	TJ	NNP
cord-332422-s15o0hie	253	3	proteins	protein	NNS
cord-332422-s15o0hie	253	4	,	,	,
cord-332422-s15o0hie	253	5	CLDN1	cldn1	NN
cord-332422-s15o0hie	253	6	and	and	CC
cord-332422-s15o0hie	253	7	OCLN	OCLN	NNP
cord-332422-s15o0hie	253	8	,	,	,
cord-332422-s15o0hie	253	9	are	be	VBP
cord-332422-s15o0hie	253	10	required	require	VBN
cord-332422-s15o0hie	253	11	.	.	.
cord-332422-s15o0hie	254	1	However	however	RB
cord-332422-s15o0hie	254	2	,	,	,
cord-332422-s15o0hie	254	3	the	the	DT
cord-332422-s15o0hie	254	4	role	role	NN
cord-332422-s15o0hie	254	5	of	of	IN
cord-332422-s15o0hie	254	6	CD81	CD81	NNP
cord-332422-s15o0hie	254	7	in	in	IN
cord-332422-s15o0hie	254	8	this	this	DT
cord-332422-s15o0hie	254	9	mechanism	mechanism	NN
cord-332422-s15o0hie	254	10	is	be	VBZ
cord-332422-s15o0hie	254	11	more	more	RBR
cord-332422-s15o0hie	254	12	controversial	controversial	JJ
cord-332422-s15o0hie	254	13	.	.	.
cord-332422-s15o0hie	255	1	It	-PRON-	PRP
cord-332422-s15o0hie	255	2	was	be	VBD
cord-332422-s15o0hie	255	3	first	first	RB
cord-332422-s15o0hie	255	4	proposed	propose	VBN
cord-332422-s15o0hie	255	5	that	that	IN
cord-332422-s15o0hie	255	6	HCV	HCV	NNP
cord-332422-s15o0hie	255	7	cell	cell	NN
cord-332422-s15o0hie	255	8	-	-	HYPH
cord-332422-s15o0hie	255	9	to	to	IN
cord-332422-s15o0hie	255	10	-	-	HYPH
cord-332422-s15o0hie	255	11	cell	cell	NN
cord-332422-s15o0hie	255	12	transmission	transmission	NN
cord-332422-s15o0hie	255	13	occurs	occur	VBZ
cord-332422-s15o0hie	255	14	independently	independently	RB
cord-332422-s15o0hie	255	15	of	of	IN
cord-332422-s15o0hie	255	16	CD81	CD81	NNP
cord-332422-s15o0hie	255	17	[	[	-LRB-
cord-332422-s15o0hie	255	18	74	74	CD
cord-332422-s15o0hie	255	19	]	]	-RRB-
cord-332422-s15o0hie	255	20	[	[	-LRB-
cord-332422-s15o0hie	255	21	75	75	CD
cord-332422-s15o0hie	255	22	]	]	-RRB-
cord-332422-s15o0hie	255	23	[	[	-LRB-
cord-332422-s15o0hie	255	24	76	76	CD
cord-332422-s15o0hie	255	25	]	]	-RRB-
cord-332422-s15o0hie	255	26	.	.	.
cord-332422-s15o0hie	256	1	Antibodies	antibody	NNS
cord-332422-s15o0hie	256	2	directed	direct	VBN
cord-332422-s15o0hie	256	3	against	against	IN
cord-332422-s15o0hie	256	4	CD81	CD81	NNP
cord-332422-s15o0hie	256	5	are	be	VBP
cord-332422-s15o0hie	256	6	unable	unable	JJ
cord-332422-s15o0hie	256	7	to	to	TO
cord-332422-s15o0hie	256	8	inhibit	inhibit	VB
cord-332422-s15o0hie	256	9	HCV	HCV	NNP
cord-332422-s15o0hie	256	10	cellto	cellto	NN
cord-332422-s15o0hie	256	11	-	-	HYPH
cord-332422-s15o0hie	256	12	cell	cell	NN
cord-332422-s15o0hie	256	13	transfer	transfer	NN
cord-332422-s15o0hie	256	14	,	,	,
cord-332422-s15o0hie	256	15	and	and	CC
cord-332422-s15o0hie	256	16	transfer	transfer	VB
cord-332422-s15o0hie	256	17	to	to	IN
cord-332422-s15o0hie	256	18	cells	cell	NNS
cord-332422-s15o0hie	256	19	expressing	express	VBG
cord-332422-s15o0hie	256	20	almost	almost	RB
cord-332422-s15o0hie	256	21	undetectable	undetectable	JJ
cord-332422-s15o0hie	256	22	levels	level	NNS
cord-332422-s15o0hie	256	23	of	of	IN
cord-332422-s15o0hie	256	24	CD81	CD81	NNP
cord-332422-s15o0hie	256	25	was	be	VBD
cord-332422-s15o0hie	256	26	observed	observe	VBN
cord-332422-s15o0hie	256	27	.	.	.
cord-332422-s15o0hie	257	1	In	in	IN
cord-332422-s15o0hie	257	2	addition	addition	NN
cord-332422-s15o0hie	257	3	,	,	,
cord-332422-s15o0hie	257	4	in	in	IN
cord-332422-s15o0hie	257	5	a	a	DT
cord-332422-s15o0hie	257	6	model	model	NN
cord-332422-s15o0hie	257	7	of	of	IN
cord-332422-s15o0hie	257	8	uPA(+/+)SCID	uPA(+/+)SCID	NNP
cord-332422-s15o0hie	257	9	mice	mice	NN
cord-332422-s15o0hie	257	10	with	with	IN
cord-332422-s15o0hie	257	11	humanized	humanized	JJ
cord-332422-s15o0hie	257	12	liver	liver	NN
cord-332422-s15o0hie	257	13	[	[	-LRB-
cord-332422-s15o0hie	257	14	78	78	CD
cord-332422-s15o0hie	257	15	]	]	-RRB-
cord-332422-s15o0hie	257	16	,	,	,
cord-332422-s15o0hie	257	17	Meuleman	Meuleman	NNP
cord-332422-s15o0hie	257	18	et	et	NNP
cord-332422-s15o0hie	257	19	al	al	NNP
cord-332422-s15o0hie	257	20	.	.	NNP
cord-332422-s15o0hie	257	21	showed	show	VBD
cord-332422-s15o0hie	257	22	that	that	IN
cord-332422-s15o0hie	257	23	prophylactic	prophylactic	JJ
cord-332422-s15o0hie	257	24	treatment	treatment	NN
cord-332422-s15o0hie	257	25	with	with	IN
cord-332422-s15o0hie	257	26	anti	anti	JJ
cord-332422-s15o0hie	257	27	-	-	JJ
cord-332422-s15o0hie	257	28	CD81	cd81	JJ
cord-332422-s15o0hie	257	29	antibodies	antibody	NNS
cord-332422-s15o0hie	257	30	prevented	prevent	VBD
cord-332422-s15o0hie	257	31	infection	infection	NN
cord-332422-s15o0hie	257	32	,	,	,
cord-332422-s15o0hie	257	33	but	but	CC
cord-332422-s15o0hie	257	34	postinfection	postinfection	NN
cord-332422-s15o0hie	257	35	treatment	treatment	NN
cord-332422-s15o0hie	257	36	had	have	VBD
cord-332422-s15o0hie	257	37	no	no	DT
cord-332422-s15o0hie	257	38	effect	effect	NN
cord-332422-s15o0hie	257	39	.	.	.
cord-332422-s15o0hie	258	1	These	these	DT
cord-332422-s15o0hie	258	2	results	result	NNS
cord-332422-s15o0hie	258	3	suggest	suggest	VBP
cord-332422-s15o0hie	258	4	that	that	IN
cord-332422-s15o0hie	258	5	virus	virus	NN
cord-332422-s15o0hie	258	6	spread	spread	VBN
cord-332422-s15o0hie	258	7	may	may	MD
cord-332422-s15o0hie	258	8	be	be	VB
cord-332422-s15o0hie	258	9	CD81-independent	cd81-independent	CD
cord-332422-s15o0hie	258	10	.	.	.
cord-332422-s15o0hie	259	1	However	however	RB
cord-332422-s15o0hie	259	2	,	,	,
cord-332422-s15o0hie	259	3	these	these	DT
cord-332422-s15o0hie	259	4	data	datum	NNS
cord-332422-s15o0hie	259	5	were	be	VBD
cord-332422-s15o0hie	259	6	challenged	challenge	VBN
cord-332422-s15o0hie	259	7	by	by	IN
cord-332422-s15o0hie	259	8	other	other	JJ
cord-332422-s15o0hie	259	9	studies	study	NNS
cord-332422-s15o0hie	259	10	in	in	IN
cord-332422-s15o0hie	259	11	which	which	WDT
cord-332422-s15o0hie	259	12	cell	cell	NN
cord-332422-s15o0hie	259	13	-	-	HYPH
cord-332422-s15o0hie	259	14	to	to	IN
cord-332422-s15o0hie	259	15	-	-	HYPH
cord-332422-s15o0hie	259	16	cell	cell	NN
cord-332422-s15o0hie	259	17	transmission	transmission	NN
cord-332422-s15o0hie	259	18	was	be	VBD
cord-332422-s15o0hie	259	19	abolished	abolish	VBN
cord-332422-s15o0hie	259	20	in	in	IN
cord-332422-s15o0hie	259	21	cells	cell	NNS
cord-332422-s15o0hie	259	22	lacking	lack	VBG
cord-332422-s15o0hie	259	23	CD81	CD81	NNP
cord-332422-s15o0hie	259	24	or	or	CC
cord-332422-s15o0hie	259	25	treated	treat	VBN
cord-332422-s15o0hie	259	26	with	with	IN
cord-332422-s15o0hie	259	27	anti	anti	JJ
cord-332422-s15o0hie	259	28	-	-	JJ
cord-332422-s15o0hie	259	29	CD81	cd81	JJ
cord-332422-s15o0hie	259	30	antibodies	antibody	NNS
cord-332422-s15o0hie	259	31	[	[	-LRB-
cord-332422-s15o0hie	259	32	77	77	CD
cord-332422-s15o0hie	259	33	,	,	,
cord-332422-s15o0hie	259	34	79	79	CD
cord-332422-s15o0hie	259	35	]	]	-RRB-
cord-332422-s15o0hie	259	36	.	.	.
cord-332422-s15o0hie	260	1	Compared	compare	VBN
cord-332422-s15o0hie	260	2	to	to	IN
cord-332422-s15o0hie	260	3	cell	cell	NN
cord-332422-s15o0hie	260	4	-	-	HYPH
cord-332422-s15o0hie	260	5	free	free	JJ
cord-332422-s15o0hie	260	6	infection	infection	NN
cord-332422-s15o0hie	260	7	,	,	,
cord-332422-s15o0hie	260	8	the	the	DT
cord-332422-s15o0hie	260	9	role	role	NN
cord-332422-s15o0hie	260	10	of	of	IN
cord-332422-s15o0hie	260	11	SRB1	SRB1	NNP
cord-332422-s15o0hie	260	12	in	in	IN
cord-332422-s15o0hie	260	13	cellto	cellto	NNP
cord-332422-s15o0hie	260	14	-	-	HYPH
cord-332422-s15o0hie	260	15	cell	cell	NN
cord-332422-s15o0hie	260	16	transmission	transmission	NN
cord-332422-s15o0hie	260	17	is	be	VBZ
cord-332422-s15o0hie	260	18	likely	likely	RB
cord-332422-s15o0hie	260	19	more	more	RBR
cord-332422-s15o0hie	260	20	important	important	JJ
cord-332422-s15o0hie	260	21	.	.	.
cord-332422-s15o0hie	261	1	Indeed	indeed	RB
cord-332422-s15o0hie	261	2	,	,	,
cord-332422-s15o0hie	261	3	the	the	DT
cord-332422-s15o0hie	261	4	neutralizing	neutralize	VBG
cord-332422-s15o0hie	261	5	effect	effect	NN
cord-332422-s15o0hie	261	6	of	of	IN
cord-332422-s15o0hie	261	7	anti	anti	JJ
cord-332422-s15o0hie	261	8	-	-	JJ
cord-332422-s15o0hie	261	9	SRB1	srb1	JJ
cord-332422-s15o0hie	261	10	antibodies	antibody	NNS
cord-332422-s15o0hie	261	11	and	and	CC
cord-332422-s15o0hie	261	12	specific	specific	JJ
cord-332422-s15o0hie	261	13	inhibitors	inhibitor	NNS
cord-332422-s15o0hie	261	14	was	be	VBD
cord-332422-s15o0hie	261	15	more	more	RBR
cord-332422-s15o0hie	261	16	pronounced	pronounced	JJ
cord-332422-s15o0hie	261	17	on	on	IN
cord-332422-s15o0hie	261	18	this	this	DT
cord-332422-s15o0hie	261	19	infection	infection	NN
cord-332422-s15o0hie	261	20	route	route	NN
cord-332422-s15o0hie	261	21	.	.	.
cord-332422-s15o0hie	262	1	In	in	IN
cord-332422-s15o0hie	262	2	addition	addition	NN
cord-332422-s15o0hie	262	3	,	,	,
cord-332422-s15o0hie	262	4	the	the	DT
cord-332422-s15o0hie	262	5	mutant	mutant	JJ
cord-332422-s15o0hie	262	6	JFH-1G451R	JFH-1G451R	NNP
cord-332422-s15o0hie	262	7	,	,	,
cord-332422-s15o0hie	262	8	which	which	WDT
cord-332422-s15o0hie	262	9	displays	display	VBZ
cord-332422-s15o0hie	262	10	less	less	JJR
cord-332422-s15o0hie	262	11	dependency	dependency	NN
cord-332422-s15o0hie	262	12	on	on	IN
cord-332422-s15o0hie	262	13	SRB1	SRB1	NNP
cord-332422-s15o0hie	262	14	,	,	,
cord-332422-s15o0hie	262	15	demonstrated	demonstrate	VBD
cord-332422-s15o0hie	262	16	a	a	DT
cord-332422-s15o0hie	262	17	reduced	reduce	VBN
cord-332422-s15o0hie	262	18	cell	cell	NN
cord-332422-s15o0hie	262	19	-	-	HYPH
cord-332422-s15o0hie	262	20	to	to	IN
cord-332422-s15o0hie	262	21	-	-	HYPH
cord-332422-s15o0hie	262	22	cell	cell	NN
cord-332422-s15o0hie	262	23	transmission	transmission	NN
cord-332422-s15o0hie	262	24	.	.	.
cord-332422-s15o0hie	263	1	In	in	IN
cord-332422-s15o0hie	263	2	the	the	DT
cord-332422-s15o0hie	263	3	early	early	JJ
cord-332422-s15o0hie	263	4	endosome	endosome	NN
cord-332422-s15o0hie	263	5	,	,	,
cord-332422-s15o0hie	263	6	fusion	fusion	NN
cord-332422-s15o0hie	263	7	between	between	IN
cord-332422-s15o0hie	263	8	the	the	DT
cord-332422-s15o0hie	263	9	viral	viral	JJ
cord-332422-s15o0hie	263	10	envelope	envelope	NN
cord-332422-s15o0hie	263	11	and	and	CC
cord-332422-s15o0hie	263	12	a	a	DT
cord-332422-s15o0hie	263	13	host	host	NN
cord-332422-s15o0hie	263	14	membrane	membrane	NN
cord-332422-s15o0hie	263	15	occurs	occur	VBZ
cord-332422-s15o0hie	263	16	,	,	,
cord-332422-s15o0hie	263	17	thus	thus	RB
cord-332422-s15o0hie	263	18	allowing	allow	VBG
cord-332422-s15o0hie	263	19	the	the	DT
cord-332422-s15o0hie	263	20	nucleocapsid	nucleocapsid	NN
cord-332422-s15o0hie	263	21	to	to	TO
cord-332422-s15o0hie	263	22	be	be	VB
cord-332422-s15o0hie	263	23	released	release	VBN
cord-332422-s15o0hie	263	24	into	into	IN
cord-332422-s15o0hie	263	25	the	the	DT
cord-332422-s15o0hie	263	26	cytosol	cytosol	NN
cord-332422-s15o0hie	263	27	.	.	.
cord-332422-s15o0hie	264	1	The	the	DT
cord-332422-s15o0hie	264	2	mechanism	mechanism	NN
cord-332422-s15o0hie	264	3	of	of	IN
cord-332422-s15o0hie	264	4	HCV	HCV	NNP
cord-332422-s15o0hie	264	5	fusion	fusion	NN
cord-332422-s15o0hie	264	6	is	be	VBZ
cord-332422-s15o0hie	264	7	poorly	poorly	RB
cord-332422-s15o0hie	264	8	understood	understand	VBN
cord-332422-s15o0hie	264	9	.	.	.
cord-332422-s15o0hie	265	1	Fusion	fusion	NN
cord-332422-s15o0hie	265	2	of	of	IN
cord-332422-s15o0hie	265	3	the	the	DT
cord-332422-s15o0hie	265	4	viral	viral	JJ
cord-332422-s15o0hie	265	5	envelope	envelope	NN
cord-332422-s15o0hie	265	6	with	with	IN
cord-332422-s15o0hie	265	7	a	a	DT
cord-332422-s15o0hie	265	8	host	host	NN
cord-332422-s15o0hie	265	9	cell	cell	NN
cord-332422-s15o0hie	265	10	membrane	membrane	NN
cord-332422-s15o0hie	265	11	is	be	VBZ
cord-332422-s15o0hie	265	12	driven	drive	VBN
cord-332422-s15o0hie	265	13	by	by	IN
cord-332422-s15o0hie	265	14	the	the	DT
cord-332422-s15o0hie	265	15	viral	viral	JJ
cord-332422-s15o0hie	265	16	fusion	fusion	NN
cord-332422-s15o0hie	265	17	protein	protein	NN
cord-332422-s15o0hie	265	18	,	,	,
cord-332422-s15o0hie	265	19	which	which	WDT
cord-332422-s15o0hie	265	20	undergoes	undergo	VBZ
cord-332422-s15o0hie	265	21	major	major	JJ
cord-332422-s15o0hie	265	22	conformational	conformational	JJ
cord-332422-s15o0hie	265	23	changes	change	NNS
cord-332422-s15o0hie	265	24	[	[	-LRB-
cord-332422-s15o0hie	265	25	9	9	CD
cord-332422-s15o0hie	265	26	]	]	-RRB-
cord-332422-s15o0hie	265	27	.	.	.
cord-332422-s15o0hie	266	1	Fusion	fusion	NN
cord-332422-s15o0hie	266	2	can	can	MD
cord-332422-s15o0hie	266	3	be	be	VB
cord-332422-s15o0hie	266	4	triggered	trigger	VBN
cord-332422-s15o0hie	266	5	by	by	IN
cord-332422-s15o0hie	266	6	different	different	JJ
cord-332422-s15o0hie	266	7	mechanisms	mechanism	NNS
cord-332422-s15o0hie	266	8	alone	alone	RB
cord-332422-s15o0hie	266	9	or	or	CC
cord-332422-s15o0hie	266	10	in	in	IN
cord-332422-s15o0hie	266	11	combinations	combination	NNS
cord-332422-s15o0hie	266	12	of	of	IN
cord-332422-s15o0hie	266	13	the	the	DT
cord-332422-s15o0hie	266	14	following	follow	VBG
cord-332422-s15o0hie	266	15	:	:	:
cord-332422-s15o0hie	266	16	receptor	receptor	NN
cord-332422-s15o0hie	266	17	binding	binding	NN
cord-332422-s15o0hie	266	18	,	,	,
cord-332422-s15o0hie	266	19	low	low	JJ
cord-332422-s15o0hie	266	20	pH	ph	NN
cord-332422-s15o0hie	266	21	exposure	exposure	NN
cord-332422-s15o0hie	266	22	and	and	CC
cord-332422-s15o0hie	266	23	proteolytic	proteolytic	JJ
cord-332422-s15o0hie	266	24	processing	processing	NN
cord-332422-s15o0hie	266	25	.	.	.
cord-332422-s15o0hie	267	1	For	for	IN
cord-332422-s15o0hie	267	2	HCV	HCV	NNP
cord-332422-s15o0hie	267	3	,	,	,
cord-332422-s15o0hie	267	4	it	-PRON-	PRP
cord-332422-s15o0hie	267	5	is	be	VBZ
cord-332422-s15o0hie	267	6	believed	believe	VBN
cord-332422-s15o0hie	267	7	that	that	IN
cord-332422-s15o0hie	267	8	E2	E2	NNP
cord-332422-s15o0hie	267	9	is	be	VBZ
cord-332422-s15o0hie	267	10	the	the	DT
cord-332422-s15o0hie	267	11	protein	protein	NN
cord-332422-s15o0hie	267	12	mediating	mediate	VBG
cord-332422-s15o0hie	267	13	fusion	fusion	NN
cord-332422-s15o0hie	267	14	.	.	.
cord-332422-s15o0hie	268	1	HCVpp	hcvpp	IN
cord-332422-s15o0hie	268	2	entry	entry	NN
cord-332422-s15o0hie	268	3	is	be	VBZ
cord-332422-s15o0hie	268	4	inhibited	inhibit	VBN
cord-332422-s15o0hie	268	5	by	by	IN
cord-332422-s15o0hie	268	6	neutralization	neutralization	NN
cord-332422-s15o0hie	268	7	of	of	IN
cord-332422-s15o0hie	268	8	endosomal	endosomal	NNP
cord-332422-s15o0hie	268	9	pH	pH	NNP
cord-332422-s15o0hie	268	10	,	,	,
cord-332422-s15o0hie	268	11	suggesting	suggest	VBG
cord-332422-s15o0hie	268	12	that	that	IN
cord-332422-s15o0hie	268	13	low	low	JJ
cord-332422-s15o0hie	268	14	pH	pH	NNP
cord-332422-s15o0hie	268	15	exposure	exposure	NN
cord-332422-s15o0hie	268	16	is	be	VBZ
cord-332422-s15o0hie	268	17	required	require	VBN
cord-332422-s15o0hie	268	18	for	for	IN
cord-332422-s15o0hie	268	19	HCV	HCV	NNP
cord-332422-s15o0hie	268	20	fusion	fusion	NN
cord-332422-s15o0hie	268	21	[	[	-LRB-
cord-332422-s15o0hie	268	22	67	67	CD
cord-332422-s15o0hie	268	23	,	,	,
cord-332422-s15o0hie	268	24	68	68	CD
cord-332422-s15o0hie	268	25	,	,	,
cord-332422-s15o0hie	268	26	80	80	CD
cord-332422-s15o0hie	268	27	]	]	-RRB-
cord-332422-s15o0hie	268	28	.	.	.
cord-332422-s15o0hie	269	1	By	by	IN
cord-332422-s15o0hie	269	2	using	use	VBG
cord-332422-s15o0hie	269	3	an	an	DT
cord-332422-s15o0hie	269	4	in	in	FW
cord-332422-s15o0hie	269	5	vitro	vitro	FW
cord-332422-s15o0hie	269	6	fusion	fusion	NN
cord-332422-s15o0hie	269	7	assay	assay	NN
cord-332422-s15o0hie	269	8	between	between	IN
cord-332422-s15o0hie	269	9	virion	virion	NN
cord-332422-s15o0hie	269	10	and	and	CC
cord-332422-s15o0hie	269	11	fluorescently	fluorescently	RB
cord-332422-s15o0hie	269	12	labeled	label	VBN
cord-332422-s15o0hie	269	13	liposomes	liposome	NNS
cord-332422-s15o0hie	269	14	,	,	,
cord-332422-s15o0hie	269	15	Haid	Haid	NNP
cord-332422-s15o0hie	269	16	et	et	NNP
cord-332422-s15o0hie	269	17	al	al	NNP
cord-332422-s15o0hie	269	18	.	.	NNP
cord-332422-s15o0hie	269	19	have	have	VBP
cord-332422-s15o0hie	269	20	reported	report	VBN
cord-332422-s15o0hie	269	21	that	that	IN
cord-332422-s15o0hie	269	22	fusion	fusion	NN
cord-332422-s15o0hie	269	23	is	be	VBZ
cord-332422-s15o0hie	269	24	triggered	trigger	VBN
cord-332422-s15o0hie	269	25	by	by	IN
cord-332422-s15o0hie	269	26	low	low	JJ
cord-332422-s15o0hie	269	27	pH	ph	NN
cord-332422-s15o0hie	269	28	and	and	CC
cord-332422-s15o0hie	269	29	is	be	VBZ
cord-332422-s15o0hie	269	30	dependent	dependent	JJ
cord-332422-s15o0hie	269	31	on	on	IN
cord-332422-s15o0hie	269	32	virus	virus	NN
cord-332422-s15o0hie	269	33	buoyant	buoyant	JJ
cord-332422-s15o0hie	269	34	density	density	NN
cord-332422-s15o0hie	269	35	and	and	CC
cord-332422-s15o0hie	269	36	the	the	DT
cord-332422-s15o0hie	269	37	lipid	lipid	NN
cord-332422-s15o0hie	269	38	composition	composition	NN
cord-332422-s15o0hie	269	39	of	of	IN
cord-332422-s15o0hie	269	40	liposomes	liposome	NNS
cord-332422-s15o0hie	269	41	[	[	-LRB-
cord-332422-s15o0hie	269	42	80	80	CD
cord-332422-s15o0hie	269	43	]	]	-RRB-
cord-332422-s15o0hie	269	44	.	.	.
cord-332422-s15o0hie	270	1	It	-PRON-	PRP
cord-332422-s15o0hie	270	2	has	have	VBZ
cord-332422-s15o0hie	270	3	been	be	VBN
cord-332422-s15o0hie	270	4	shown	show	VBN
cord-332422-s15o0hie	270	5	that	that	IN
cord-332422-s15o0hie	270	6	E1	E1	NNP
cord-332422-s15o0hie	270	7	and	and	CC
cord-332422-s15o0hie	270	8	E2	E2	NNP
cord-332422-s15o0hie	270	9	on	on	IN
cord-332422-s15o0hie	270	10	the	the	DT
cord-332422-s15o0hie	270	11	viral	viral	JJ
cord-332422-s15o0hie	270	12	surface	surface	NN
cord-332422-s15o0hie	270	13	are	be	VBP
cord-332422-s15o0hie	270	14	linked	link	VBN
cord-332422-s15o0hie	270	15	by	by	IN
cord-332422-s15o0hie	270	16	intermolecular	intermolecular	JJ
cord-332422-s15o0hie	270	17	disulfide	disulfide	JJ
cord-332422-s15o0hie	270	18	bridges	bridge	NNS
cord-332422-s15o0hie	270	19	[	[	-LRB-
cord-332422-s15o0hie	270	20	7	7	CD
cord-332422-s15o0hie	270	21	]	]	-RRB-
cord-332422-s15o0hie	270	22	.	.	.
cord-332422-s15o0hie	271	1	These	these	DT
cord-332422-s15o0hie	271	2	large	large	JJ
cord-332422-s15o0hie	271	3	oligomers	oligomer	NNS
cord-332422-s15o0hie	271	4	may	may	MD
cord-332422-s15o0hie	271	5	form	form	VB
cord-332422-s15o0hie	271	6	a	a	DT
cord-332422-s15o0hie	271	7	rigid	rigid	JJ
cord-332422-s15o0hie	271	8	protein	protein	NN
cord-332422-s15o0hie	271	9	lattice	lattice	NN
cord-332422-s15o0hie	271	10	which	which	WDT
cord-332422-s15o0hie	271	11	may	may	MD
cord-332422-s15o0hie	271	12	have	have	VB
cord-332422-s15o0hie	271	13	consequences	consequence	NNS
cord-332422-s15o0hie	271	14	for	for	IN
cord-332422-s15o0hie	271	15	the	the	DT
cord-332422-s15o0hie	271	16	fusion	fusion	NN
cord-332422-s15o0hie	271	17	process	process	NN
cord-332422-s15o0hie	271	18	.	.	.
cord-332422-s15o0hie	272	1	Class	class	NN
cord-332422-s15o0hie	272	2	II	II	NNP
cord-332422-s15o0hie	272	3	fusion	fusion	NN
cord-332422-s15o0hie	272	4	proteins	protein	NNS
cord-332422-s15o0hie	272	5	undergo	undergo	VBP
cord-332422-s15o0hie	272	6	an	an	DT
cord-332422-s15o0hie	272	7	oligomeric	oligomeric	JJ
cord-332422-s15o0hie	272	8	rearrangement	rearrangement	NN
cord-332422-s15o0hie	272	9	during	during	IN
cord-332422-s15o0hie	272	10	the	the	DT
cord-332422-s15o0hie	272	11	fusion	fusion	NN
cord-332422-s15o0hie	272	12	process	process	NN
cord-332422-s15o0hie	272	13	,	,	,
cord-332422-s15o0hie	272	14	which	which	WDT
cord-332422-s15o0hie	272	15	leads	lead	VBZ
cord-332422-s15o0hie	272	16	to	to	IN
cord-332422-s15o0hie	272	17	the	the	DT
cord-332422-s15o0hie	272	18	conversion	conversion	NN
cord-332422-s15o0hie	272	19	into	into	IN
cord-332422-s15o0hie	272	20	trimers	trimer	NNS
cord-332422-s15o0hie	272	21	.	.	.
cord-332422-s15o0hie	273	1	It	-PRON-	PRP
cord-332422-s15o0hie	273	2	is	be	VBZ
cord-332422-s15o0hie	273	3	likely	likely	JJ
cord-332422-s15o0hie	273	4	that	that	IN
cord-332422-s15o0hie	273	5	disulfide	disulfide	JJ
cord-332422-s15o0hie	273	6	rearrangements	rearrangement	NNS
cord-332422-s15o0hie	273	7	are	be	VBP
cord-332422-s15o0hie	273	8	required	require	VBN
cord-332422-s15o0hie	273	9	to	to	IN
cord-332422-s15o0hie	273	10	prime	prime	JJ
cord-332422-s15o0hie	273	11	HCV	HCV	NNP
cord-332422-s15o0hie	273	12	fusion	fusion	NN
cord-332422-s15o0hie	273	13	process	process	NN
cord-332422-s15o0hie	273	14	.	.	.
cord-332422-s15o0hie	274	1	Critical	critical	JJ
cord-332422-s15o0hie	274	2	reshuffling	reshuffling	NN
cord-332422-s15o0hie	274	3	of	of	IN
cord-332422-s15o0hie	274	4	disulfide	disulfide	JJ
cord-332422-s15o0hie	274	5	bonds	bond	NNS
cord-332422-s15o0hie	274	6	has	have	VBZ
cord-332422-s15o0hie	274	7	already	already	RB
cord-332422-s15o0hie	274	8	been	be	VBN
cord-332422-s15o0hie	274	9	shown	show	VBN
cord-332422-s15o0hie	274	10	to	to	TO
cord-332422-s15o0hie	274	11	occur	occur	VB
cord-332422-s15o0hie	274	12	for	for	IN
cord-332422-s15o0hie	274	13	other	other	JJ
cord-332422-s15o0hie	274	14	viruses	virus	NNS
cord-332422-s15o0hie	274	15	such	such	JJ
cord-332422-s15o0hie	274	16	as	as	IN
cord-332422-s15o0hie	274	17	Sindbis	Sindbis	NNP
cord-332422-s15o0hie	274	18	virus	virus	NN
cord-332422-s15o0hie	274	19	and	and	CC
cord-332422-s15o0hie	274	20	HIV	HIV	NNP
cord-332422-s15o0hie	274	21	[	[	-LRB-
cord-332422-s15o0hie	274	22	81	81	CD
cord-332422-s15o0hie	274	23	,	,	,
cord-332422-s15o0hie	274	24	82	82	CD
cord-332422-s15o0hie	274	25	]	]	-RRB-
cord-332422-s15o0hie	274	26	.	.	.
cord-332422-s15o0hie	275	1	For	for	IN
cord-332422-s15o0hie	275	2	HIV	HIV	NNP
cord-332422-s15o0hie	275	3	,	,	,
cord-332422-s15o0hie	275	4	it	-PRON-	PRP
cord-332422-s15o0hie	275	5	has	have	VBZ
cord-332422-s15o0hie	275	6	been	be	VBN
cord-332422-s15o0hie	275	7	proposed	propose	VBN
cord-332422-s15o0hie	275	8	that	that	IN
cord-332422-s15o0hie	275	9	protein	protein	NN
cord-332422-s15o0hie	275	10	disulfide	disulfide	NN
cord-332422-s15o0hie	275	11	isomerase	isomerase	NN
cord-332422-s15o0hie	275	12	(	(	-LRB-
cord-332422-s15o0hie	275	13	PDI	PDI	NNP
cord-332422-s15o0hie	275	14	)	)	-RRB-
cord-332422-s15o0hie	275	15	can	can	MD
cord-332422-s15o0hie	275	16	act	act	VB
cord-332422-s15o0hie	275	17	at	at	IN
cord-332422-s15o0hie	275	18	a	a	DT
cord-332422-s15o0hie	275	19	post	post	JJ
cord-332422-s15o0hie	275	20	-	-	JJ
cord-332422-s15o0hie	275	21	binding	binding	JJ
cord-332422-s15o0hie	275	22	step	step	NN
cord-332422-s15o0hie	275	23	to	to	TO
cord-332422-s15o0hie	275	24	reduce	reduce	VB
cord-332422-s15o0hie	275	25	two	two	CD
cord-332422-s15o0hie	275	26	disulfide	disulfide	JJ
cord-332422-s15o0hie	275	27	bonds	bond	NNS
cord-332422-s15o0hie	275	28	in	in	IN
cord-332422-s15o0hie	275	29	gp120	gp120	CD
cord-332422-s15o0hie	275	30	which	which	WDT
cord-332422-s15o0hie	275	31	consequently	consequently	RB
cord-332422-s15o0hie	275	32	induces	induce	VBZ
cord-332422-s15o0hie	275	33	fusion	fusion	NN
cord-332422-s15o0hie	275	34	competence	competence	NN
cord-332422-s15o0hie	275	35	.	.	.
cord-332422-s15o0hie	276	1	Further	further	JJ
cord-332422-s15o0hie	276	2	investigations	investigation	NNS
cord-332422-s15o0hie	276	3	on	on	IN
cord-332422-s15o0hie	276	4	the	the	DT
cord-332422-s15o0hie	276	5	potential	potential	JJ
cord-332422-s15o0hie	276	6	role	role	NN
cord-332422-s15o0hie	276	7	of	of	IN
cord-332422-s15o0hie	276	8	PDI	PDI	NNP
cord-332422-s15o0hie	276	9	and	and	CC
cord-332422-s15o0hie	276	10	the	the	DT
cord-332422-s15o0hie	276	11	disulfide	disulfide	NN
cord-332422-s15o0hie	276	12	-	-	HYPH
cord-332422-s15o0hie	276	13	bond	bond	NN
cord-332422-s15o0hie	276	14	rearrangement	rearrangement	NN
cord-332422-s15o0hie	276	15	of	of	IN
cord-332422-s15o0hie	276	16	HCV	HCV	NNP
cord-332422-s15o0hie	276	17	envelope	envelope	NN
cord-332422-s15o0hie	276	18	proteins	protein	NNS
cord-332422-s15o0hie	276	19	are	be	VBP
cord-332422-s15o0hie	276	20	needed	need	VBN
cord-332422-s15o0hie	276	21	to	to	TO
cord-332422-s15o0hie	276	22	further	further	RB
cord-332422-s15o0hie	276	23	understand	understand	VB
cord-332422-s15o0hie	276	24	the	the	DT
cord-332422-s15o0hie	276	25	fusion	fusion	NN
cord-332422-s15o0hie	276	26	process	process	NN
cord-332422-s15o0hie	276	27	.	.	.
cord-332422-s15o0hie	277	1	With	with	IN
cord-332422-s15o0hie	277	2	the	the	DT
cord-332422-s15o0hie	277	3	development	development	NN
cord-332422-s15o0hie	277	4	of	of	IN
cord-332422-s15o0hie	277	5	a	a	DT
cord-332422-s15o0hie	277	6	cell	cell	NN
cord-332422-s15o0hie	277	7	culture	culture	NN
cord-332422-s15o0hie	277	8	system	system	NN
cord-332422-s15o0hie	277	9	to	to	TO
cord-332422-s15o0hie	277	10	propagate	propagate	VB
cord-332422-s15o0hie	277	11	the	the	DT
cord-332422-s15o0hie	277	12	virus	virus	NN
cord-332422-s15o0hie	277	13	,	,	,
cord-332422-s15o0hie	277	14	considerable	considerable	JJ
cord-332422-s15o0hie	277	15	progress	progress	NN
cord-332422-s15o0hie	277	16	has	have	VBZ
cord-332422-s15o0hie	277	17	been	be	VBN
cord-332422-s15o0hie	277	18	made	make	VBN
cord-332422-s15o0hie	277	19	in	in	IN
cord-332422-s15o0hie	277	20	understanding	understand	VBG
cord-332422-s15o0hie	277	21	the	the	DT
cord-332422-s15o0hie	277	22	HCV	HCV	NNP
cord-332422-s15o0hie	277	23	life	life	NN
cord-332422-s15o0hie	277	24	cycle	cycle	NN
cord-332422-s15o0hie	277	25	.	.	.
cord-332422-s15o0hie	278	1	The	the	DT
cord-332422-s15o0hie	278	2	data	datum	NNS
cord-332422-s15o0hie	278	3	accumulated	accumulate	VBN
cord-332422-s15o0hie	278	4	on	on	IN
cord-332422-s15o0hie	278	5	this	this	DT
cord-332422-s15o0hie	278	6	virus	virus	NN
cord-332422-s15o0hie	278	7	indicate	indicate	VBP
cord-332422-s15o0hie	278	8	that	that	IN
cord-332422-s15o0hie	278	9	HCV	HCV	NNP
cord-332422-s15o0hie	278	10	enters	enter	VBZ
cord-332422-s15o0hie	278	11	into	into	IN
cord-332422-s15o0hie	278	12	host	host	NN
cord-332422-s15o0hie	278	13	cells	cell	NNS
cord-332422-s15o0hie	278	14	in	in	IN
cord-332422-s15o0hie	278	15	a	a	DT
cord-332422-s15o0hie	278	16	tightly	tightly	RB
cord-332422-s15o0hie	278	17	regulated	regulated	JJ
cord-332422-s15o0hie	278	18	and	and	CC
cord-332422-s15o0hie	278	19	complex	complex	JJ
cord-332422-s15o0hie	278	20	multistep	multistep	NN
cord-332422-s15o0hie	278	21	process	process	NN
cord-332422-s15o0hie	278	22	involving	involve	VBG
cord-332422-s15o0hie	278	23	the	the	DT
cord-332422-s15o0hie	278	24	presence	presence	NN
cord-332422-s15o0hie	278	25	of	of	IN
cord-332422-s15o0hie	278	26	several	several	JJ
cord-332422-s15o0hie	278	27	entry	entry	NN
cord-332422-s15o0hie	278	28	factors	factor	NNS
cord-332422-s15o0hie	278	29	.	.	.
cord-332422-s15o0hie	279	1	Another	another	DT
cord-332422-s15o0hie	279	2	peculiarity	peculiarity	NN
cord-332422-s15o0hie	279	3	of	of	IN
cord-332422-s15o0hie	279	4	HCV	HCV	NNP
cord-332422-s15o0hie	279	5	is	be	VBZ
cord-332422-s15o0hie	279	6	the	the	DT
cord-332422-s15o0hie	279	7	hybrid	hybrid	JJ
cord-332422-s15o0hie	279	8	nature	nature	NN
cord-332422-s15o0hie	279	9	of	of	IN
cord-332422-s15o0hie	279	10	the	the	DT
cord-332422-s15o0hie	279	11	lipoviroparticle	lipoviroparticle	NNP
cord-332422-s15o0hie	279	12	.	.	.
cord-332422-s15o0hie	280	1	The	the	DT
cord-332422-s15o0hie	280	2	recent	recent	JJ
cord-332422-s15o0hie	280	3	progress	progress	NN
cord-332422-s15o0hie	280	4	on	on	IN
cord-332422-s15o0hie	280	5	HCV	HCV	NNP
cord-332422-s15o0hie	280	6	entry	entry	NN
cord-332422-s15o0hie	280	7	has	have	VBZ
cord-332422-s15o0hie	280	8	highlighted	highlight	VBN
cord-332422-s15o0hie	280	9	the	the	DT
cord-332422-s15o0hie	280	10	contribution	contribution	NN
cord-332422-s15o0hie	280	11	of	of	IN
cord-332422-s15o0hie	280	12	both	both	DT
cord-332422-s15o0hie	280	13	HCV	HCV	NNP
cord-332422-s15o0hie	280	14	envelope	envelope	NN
cord-332422-s15o0hie	280	15	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	280	16	and	and	CC
cord-332422-s15o0hie	280	17	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	280	18	moieties	moiety	NNS
cord-332422-s15o0hie	280	19	.	.	.
cord-332422-s15o0hie	281	1	Virus	virus	NN
cord-332422-s15o0hie	281	2	-	-	HYPH
cord-332422-s15o0hie	281	3	associated	associate	VBN
cord-332422-s15o0hie	281	4	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	281	5	are	be	VBP
cord-332422-s15o0hie	281	6	likely	likely	RB
cord-332422-s15o0hie	281	7	playing	play	VBG
cord-332422-s15o0hie	281	8	a	a	DT
cord-332422-s15o0hie	281	9	role	role	NN
cord-332422-s15o0hie	281	10	in	in	IN
cord-332422-s15o0hie	281	11	the	the	DT
cord-332422-s15o0hie	281	12	early	early	JJ
cord-332422-s15o0hie	281	13	phase	phase	NN
cord-332422-s15o0hie	281	14	of	of	IN
cord-332422-s15o0hie	281	15	HCV	HCV	NNP
cord-332422-s15o0hie	281	16	entry	entry	NN
cord-332422-s15o0hie	281	17	,	,	,
cord-332422-s15o0hie	281	18	whereas	whereas	IN
cord-332422-s15o0hie	281	19	envelope	envelope	NN
cord-332422-s15o0hie	281	20	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	281	21	are	be	VBP
cord-332422-s15o0hie	281	22	believed	believe	VBN
cord-332422-s15o0hie	281	23	to	to	TO
cord-332422-s15o0hie	281	24	take	take	VB
cord-332422-s15o0hie	281	25	the	the	DT
cord-332422-s15o0hie	281	26	lead	lead	NN
cord-332422-s15o0hie	281	27	after	after	IN
cord-332422-s15o0hie	281	28	this	this	DT
cord-332422-s15o0hie	281	29	initial	initial	JJ
cord-332422-s15o0hie	281	30	step	step	NN
cord-332422-s15o0hie	281	31	.	.	.
cord-332422-s15o0hie	282	1	However	however	RB
cord-332422-s15o0hie	282	2	,	,	,
cord-332422-s15o0hie	282	3	the	the	DT
cord-332422-s15o0hie	282	4	details	detail	NNS
cord-332422-s15o0hie	282	5	of	of	IN
cord-332422-s15o0hie	282	6	successive	successive	JJ
cord-332422-s15o0hie	282	7	events	event	NNS
cord-332422-s15o0hie	282	8	occuring	occur	VBG
cord-332422-s15o0hie	282	9	during	during	IN
cord-332422-s15o0hie	282	10	HCV	HCV	NNP
cord-332422-s15o0hie	282	11	entry	entry	NN
cord-332422-s15o0hie	282	12	remain	remain	VBP
cord-332422-s15o0hie	282	13	to	to	TO
cord-332422-s15o0hie	282	14	be	be	VB
cord-332422-s15o0hie	282	15	revealed	reveal	VBN
cord-332422-s15o0hie	282	16	.	.	.
cord-332422-s15o0hie	283	1	The	the	DT
cord-332422-s15o0hie	283	2	recent	recent	JJ
cord-332422-s15o0hie	283	3	structural	structural	JJ
cord-332422-s15o0hie	283	4	model	model	NN
cord-332422-s15o0hie	283	5	of	of	IN
cord-332422-s15o0hie	283	6	E2	E2	NNP
cord-332422-s15o0hie	283	7	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	283	8	provides	provide	VBZ
cord-332422-s15o0hie	283	9	a	a	DT
cord-332422-s15o0hie	283	10	new	new	JJ
cord-332422-s15o0hie	283	11	framework	framework	NN
cord-332422-s15o0hie	283	12	for	for	IN
cord-332422-s15o0hie	283	13	a	a	DT
cord-332422-s15o0hie	283	14	better	well	JJR
cord-332422-s15o0hie	283	15	understanding	understanding	NN
cord-332422-s15o0hie	283	16	of	of	IN
cord-332422-s15o0hie	283	17	the	the	DT
cord-332422-s15o0hie	283	18	structure	structure	NN
cord-332422-s15o0hie	283	19	-	-	HYPH
cord-332422-s15o0hie	283	20	function	function	NN
cord-332422-s15o0hie	283	21	relationship	relationship	NN
cord-332422-s15o0hie	283	22	of	of	IN
cord-332422-s15o0hie	283	23	HCV	HCV	NNP
cord-332422-s15o0hie	283	24	envelope	envelope	NN
cord-332422-s15o0hie	283	25	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	283	26	,	,	,
cord-332422-s15o0hie	283	27	which	which	WDT
cord-332422-s15o0hie	283	28	will	will	MD
cord-332422-s15o0hie	283	29	lead	lead	VB
cord-332422-s15o0hie	283	30	to	to	IN
cord-332422-s15o0hie	283	31	a	a	DT
cord-332422-s15o0hie	283	32	better	well	RBR
cord-332422-s15o0hie	283	33	mechanistic	mechanistic	JJ
cord-332422-s15o0hie	283	34	understanding	understanding	NN
cord-332422-s15o0hie	283	35	of	of	IN
cord-332422-s15o0hie	283	36	the	the	DT
cord-332422-s15o0hie	283	37	entry	entry	NN
cord-332422-s15o0hie	283	38	process	process	NN
cord-332422-s15o0hie	283	39	.	.	.
cord-332422-s15o0hie	284	1	In	in	IN
cord-332422-s15o0hie	284	2	spite	spite	NN
cord-332422-s15o0hie	284	3	of	of	IN
cord-332422-s15o0hie	284	4	the	the	DT
cord-332422-s15o0hie	284	5	major	major	JJ
cord-332422-s15o0hie	284	6	progress	progress	NN
cord-332422-s15o0hie	284	7	in	in	IN
cord-332422-s15o0hie	284	8	the	the	DT
cord-332422-s15o0hie	284	9	field	field	NN
cord-332422-s15o0hie	284	10	,	,	,
cord-332422-s15o0hie	284	11	it	-PRON-	PRP
cord-332422-s15o0hie	284	12	is	be	VBZ
cord-332422-s15o0hie	284	13	still	still	RB
cord-332422-s15o0hie	284	14	unclear	unclear	JJ
cord-332422-s15o0hie	284	15	how	how	WRB
cord-332422-s15o0hie	284	16	the	the	DT
cord-332422-s15o0hie	284	17	virus	virus	NN
cord-332422-s15o0hie	284	18	overcomes	overcome	VBZ
cord-332422-s15o0hie	284	19	the	the	DT
cord-332422-s15o0hie	284	20	compact	compact	JJ
cord-332422-s15o0hie	284	21	and	and	CC
cord-332422-s15o0hie	284	22	highly	highly	RB
cord-332422-s15o0hie	284	23	organized	organize	VBN
cord-332422-s15o0hie	284	24	environment	environment	NN
cord-332422-s15o0hie	284	25	of	of	IN
cord-332422-s15o0hie	284	26	liver	liver	NN
cord-332422-s15o0hie	284	27	and	and	CC
cord-332422-s15o0hie	284	28	the	the	DT
cord-332422-s15o0hie	284	29	role	role	NN
cord-332422-s15o0hie	284	30	of	of	IN
cord-332422-s15o0hie	284	31	TJ	TJ	NNP
cord-332422-s15o0hie	284	32	formation	formation	NN
cord-332422-s15o0hie	284	33	in	in	IN
cord-332422-s15o0hie	284	34	HCV	HCV	NNP
cord-332422-s15o0hie	284	35	infection	infection	NN
cord-332422-s15o0hie	284	36	remains	remain	VBZ
cord-332422-s15o0hie	284	37	to	to	TO
cord-332422-s15o0hie	284	38	be	be	VB
cord-332422-s15o0hie	284	39	elucidated	elucidate	VBN
cord-332422-s15o0hie	284	40	.	.	.
cord-332422-s15o0hie	285	1	Replication	replication	NN
cord-332422-s15o0hie	285	2	of	of	IN
cord-332422-s15o0hie	285	3	hepatitis	hepatitis	NN
cord-332422-s15o0hie	285	4	C	C	NNP
cord-332422-s15o0hie	285	5	virus	virus	NN
cord-332422-s15o0hie	285	6	Assembly	Assembly	NNP
cord-332422-s15o0hie	285	7	of	of	IN
cord-332422-s15o0hie	285	8	infectious	infectious	JJ
cord-332422-s15o0hie	285	9	hepatitis	hepatitis	NN
cord-332422-s15o0hie	285	10	C	c	NN
cord-332422-s15o0hie	285	11	virus	virus	NN
cord-332422-s15o0hie	285	12	particles	particle	NNS
cord-332422-s15o0hie	285	13	Studying	study	VBG
cord-332422-s15o0hie	285	14	HCV	HCV	NNP
cord-332422-s15o0hie	285	15	cell	cell	NN
cord-332422-s15o0hie	285	16	entry	entry	NN
cord-332422-s15o0hie	285	17	with	with	IN
cord-332422-s15o0hie	285	18	HCV	HCV	NNP
cord-332422-s15o0hie	285	19	pseudoparticles	pseudoparticle	NNS
cord-332422-s15o0hie	285	20	(	(	-LRB-
cord-332422-s15o0hie	285	21	HCVpp	HCVpp	NNP
cord-332422-s15o0hie	285	22	)	)	-RRB-
cord-332422-s15o0hie	285	23	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	285	24	C	C	NNP
cord-332422-s15o0hie	285	25	virus	virus	NN
cord-332422-s15o0hie	285	26	molecular	molecular	JJ
cord-332422-s15o0hie	285	27	clones	clone	NNS
cord-332422-s15o0hie	285	28	:	:	:
cord-332422-s15o0hie	285	29	from	from	IN
cord-332422-s15o0hie	285	30	cDNA	cdna	NN
cord-332422-s15o0hie	285	31	to	to	IN
cord-332422-s15o0hie	285	32	infectious	infectious	JJ
cord-332422-s15o0hie	285	33	virus	virus	NN
cord-332422-s15o0hie	285	34	particles	particle	NNS
cord-332422-s15o0hie	285	35	in	in	IN
cord-332422-s15o0hie	285	36	cell	cell	NN
cord-332422-s15o0hie	285	37	culture	culture	NN
cord-332422-s15o0hie	286	1	Recent	recent	JJ
cord-332422-s15o0hie	286	2	advances	advance	NNS
cord-332422-s15o0hie	286	3	in	in	IN
cord-332422-s15o0hie	286	4	hepatitis	hepatitis	NN
cord-332422-s15o0hie	286	5	C	C	NNP
cord-332422-s15o0hie	286	6	virus	virus	NN
cord-332422-s15o0hie	286	7	entry	entry	NN
cord-332422-s15o0hie	286	8	Assembly	Assembly	NNP
cord-332422-s15o0hie	286	9	of	of	IN
cord-332422-s15o0hie	286	10	a	a	DT
cord-332422-s15o0hie	286	11	functional	functional	JJ
cord-332422-s15o0hie	286	12	HCV	HCV	NNP
cord-332422-s15o0hie	286	13	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	286	14	heterodimer	heterodimer	NN
cord-332422-s15o0hie	286	15	Characterization	characterization	NN
cord-332422-s15o0hie	286	16	of	of	IN
cord-332422-s15o0hie	286	17	the	the	DT
cord-332422-s15o0hie	286	18	envelope	envelope	NN
cord-332422-s15o0hie	286	19	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	286	20	associated	associate	VBN
cord-332422-s15o0hie	286	21	with	with	IN
cord-332422-s15o0hie	286	22	infectious	infectious	JJ
cord-332422-s15o0hie	286	23	hepatitis	hepatitis	NN
cord-332422-s15o0hie	286	24	C	c	NN
cord-332422-s15o0hie	286	25	virus	virus	NN
cord-332422-s15o0hie	286	26	Morphological	morphological	JJ
cord-332422-s15o0hie	286	27	characterization	characterization	NN
cord-332422-s15o0hie	286	28	and	and	CC
cord-332422-s15o0hie	286	29	fusion	fusion	NN
cord-332422-s15o0hie	286	30	properties	property	NNS
cord-332422-s15o0hie	286	31	of	of	IN
cord-332422-s15o0hie	286	32	triglyceride	triglyceride	NN
cord-332422-s15o0hie	286	33	-	-	HYPH
cord-332422-s15o0hie	286	34	rich	rich	JJ
cord-332422-s15o0hie	286	35	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	286	36	obtained	obtain	VBN
cord-332422-s15o0hie	286	37	from	from	IN
cord-332422-s15o0hie	286	38	cells	cell	NNS
cord-332422-s15o0hie	286	39	transduced	transduce	VBN
cord-332422-s15o0hie	286	40	with	with	IN
cord-332422-s15o0hie	286	41	hepatitis	hepatitis	NN
cord-332422-s15o0hie	286	42	C	C	NNP
cord-332422-s15o0hie	286	43	virus	virus	NN
cord-332422-s15o0hie	286	44	glycoproteins	glycoprotein	NNS
cord-332422-s15o0hie	286	45	Virus	virus	NN
cord-332422-s15o0hie	286	46	membrane	membrane	NN
cord-332422-s15o0hie	286	47	-	-	HYPH
cord-332422-s15o0hie	286	48	fusion	fusion	NN
cord-332422-s15o0hie	286	49	proteins	protein	NNS
cord-332422-s15o0hie	286	50	:	:	:
cord-332422-s15o0hie	286	51	more	more	JJR
cord-332422-s15o0hie	286	52	than	than	IN
cord-332422-s15o0hie	286	53	one	one	CD
cord-332422-s15o0hie	286	54	way	way	NN
cord-332422-s15o0hie	286	55	to	to	TO
cord-332422-s15o0hie	286	56	make	make	VB
cord-332422-s15o0hie	286	57	a	a	DT
cord-332422-s15o0hie	286	58	hairpin	hairpin	JJ
cord-332422-s15o0hie	286	59	Identification	identification	NN
cord-332422-s15o0hie	286	60	of	of	IN
cord-332422-s15o0hie	286	61	new	new	JJ
cord-332422-s15o0hie	286	62	functional	functional	JJ
cord-332422-s15o0hie	286	63	regions	region	NNS
cord-332422-s15o0hie	286	64	in	in	IN
cord-332422-s15o0hie	286	65	hepatitis	hepatitis	NN
cord-332422-s15o0hie	286	66	C	C	NNP
cord-332422-s15o0hie	286	67	virus	virus	NN
cord-332422-s15o0hie	286	68	envelope	envelope	NN
cord-332422-s15o0hie	286	69	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	286	70	E2	E2	NNP
cord-332422-s15o0hie	287	1	The	the	DT
cord-332422-s15o0hie	287	2	disulfide	disulfide	JJ
cord-332422-s15o0hie	287	3	bonds	bond	NNS
cord-332422-s15o0hie	287	4	in	in	IN
cord-332422-s15o0hie	287	5	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	287	6	E2	E2	NNP
cord-332422-s15o0hie	287	7	of	of	IN
cord-332422-s15o0hie	287	8	hepatitis	hepatitis	NN
cord-332422-s15o0hie	287	9	C	C	NNP
cord-332422-s15o0hie	287	10	virus	virus	NN
cord-332422-s15o0hie	287	11	reveal	reveal	VBP
cord-332422-s15o0hie	287	12	the	the	DT
cord-332422-s15o0hie	287	13	tertiary	tertiary	JJ
cord-332422-s15o0hie	287	14	organization	organization	NN
cord-332422-s15o0hie	287	15	of	of	IN
cord-332422-s15o0hie	287	16	the	the	DT
cord-332422-s15o0hie	287	17	molecule	molecule	NN
cord-332422-s15o0hie	287	18	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	287	19	C	C	NNP
cord-332422-s15o0hie	287	20	virus	virus	NN
cord-332422-s15o0hie	287	21	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	287	22	E2	E2	NNP
cord-332422-s15o0hie	287	23	contains	contain	VBZ
cord-332422-s15o0hie	287	24	a	a	DT
cord-332422-s15o0hie	287	25	membrane	membrane	NN
cord-332422-s15o0hie	287	26	-	-	HYPH
cord-332422-s15o0hie	287	27	proximal	proximal	JJ
cord-332422-s15o0hie	287	28	heptad	heptad	NN
cord-332422-s15o0hie	287	29	repeat	repeat	NN
cord-332422-s15o0hie	287	30	sequence	sequence	NN
cord-332422-s15o0hie	287	31	that	that	WDT
cord-332422-s15o0hie	287	32	is	be	VBZ
cord-332422-s15o0hie	287	33	essential	essential	JJ
cord-332422-s15o0hie	287	34	for	for	IN
cord-332422-s15o0hie	287	35	E1E2	E1E2	NNP
cord-332422-s15o0hie	287	36	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	287	37	heterodimerization	heterodimerization	NN
cord-332422-s15o0hie	287	38	and	and	CC
cord-332422-s15o0hie	287	39	viral	viral	JJ
cord-332422-s15o0hie	287	40	entry	entry	NN
cord-332422-s15o0hie	288	1	The	the	DT
cord-332422-s15o0hie	288	2	human	human	JJ
cord-332422-s15o0hie	288	3	scavenger	scavenger	NN
cord-332422-s15o0hie	288	4	receptor	receptor	NN
cord-332422-s15o0hie	288	5	class	class	NN
cord-332422-s15o0hie	288	6	B	b	NN
cord-332422-s15o0hie	288	7	type	type	NN
cord-332422-s15o0hie	289	1	I	-PRON-	PRP
cord-332422-s15o0hie	289	2	is	be	VBZ
cord-332422-s15o0hie	289	3	a	a	DT
cord-332422-s15o0hie	289	4	novel	novel	JJ
cord-332422-s15o0hie	289	5	candidate	candidate	NN
cord-332422-s15o0hie	289	6	receptor	receptor	NN
cord-332422-s15o0hie	289	7	for	for	IN
cord-332422-s15o0hie	289	8	the	the	DT
cord-332422-s15o0hie	289	9	hepatitis	hepatitis	NN
cord-332422-s15o0hie	289	10	C	C	NNP
cord-332422-s15o0hie	289	11	virus	virus	NN
cord-332422-s15o0hie	289	12	Hypervariable	Hypervariable	NNP
cord-332422-s15o0hie	289	13	region	region	NN
cord-332422-s15o0hie	289	14	1	1	CD
cord-332422-s15o0hie	289	15	differentially	differentially	RB
cord-332422-s15o0hie	289	16	impacts	impact	VBZ
cord-332422-s15o0hie	289	17	viability	viability	NN
cord-332422-s15o0hie	289	18	of	of	IN
cord-332422-s15o0hie	289	19	hepatitis	hepatitis	NN
cord-332422-s15o0hie	289	20	C	C	NNP
cord-332422-s15o0hie	289	21	virus	virus	NN
cord-332422-s15o0hie	289	22	strains	strain	NNS
cord-332422-s15o0hie	289	23	of	of	IN
cord-332422-s15o0hie	289	24	genotypes	genotype	NNS
cord-332422-s15o0hie	289	25	1	1	CD
cord-332422-s15o0hie	289	26	to	to	IN
cord-332422-s15o0hie	289	27	6	6	CD
cord-332422-s15o0hie	289	28	and	and	CC
cord-332422-s15o0hie	289	29	impairs	impair	VBZ
cord-332422-s15o0hie	289	30	virus	virus	NN
cord-332422-s15o0hie	289	31	neutralization	neutralization	NN
cord-332422-s15o0hie	289	32	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	289	33	C	C	NNP
cord-332422-s15o0hie	289	34	virus	virus	NN
cord-332422-s15o0hie	289	35	hypervariable	hypervariable	NN
cord-332422-s15o0hie	289	36	region	region	NN
cord-332422-s15o0hie	289	37	1	1	CD
cord-332422-s15o0hie	289	38	modulates	modulate	VBZ
cord-332422-s15o0hie	289	39	receptor	receptor	NN
cord-332422-s15o0hie	289	40	interactions	interaction	NNS
cord-332422-s15o0hie	289	41	,	,	,
cord-332422-s15o0hie	289	42	conceals	conceal	VBZ
cord-332422-s15o0hie	289	43	the	the	DT
cord-332422-s15o0hie	289	44	CD81	CD81	NNP
cord-332422-s15o0hie	289	45	binding	binding	NN
cord-332422-s15o0hie	289	46	site	site	NN
cord-332422-s15o0hie	289	47	,	,	,
cord-332422-s15o0hie	289	48	and	and	CC
cord-332422-s15o0hie	289	49	protects	protect	VBZ
cord-332422-s15o0hie	289	50	conserved	conserve	VBN
cord-332422-s15o0hie	289	51	neutralizing	neutralize	VBG
cord-332422-s15o0hie	289	52	epitopes	epitope	NNS
cord-332422-s15o0hie	290	1	The	the	DT
cord-332422-s15o0hie	290	2	neutralizing	neutralize	VBG
cord-332422-s15o0hie	290	3	activity	activity	NN
cord-332422-s15o0hie	290	4	of	of	IN
cord-332422-s15o0hie	290	5	anti	anti	JJ
cord-332422-s15o0hie	290	6	-	-	JJ
cord-332422-s15o0hie	290	7	hepatitis	hepatitis	JJ
cord-332422-s15o0hie	290	8	C	c	NN
cord-332422-s15o0hie	290	9	virus	virus	NN
cord-332422-s15o0hie	290	10	antibodies	antibody	NNS
cord-332422-s15o0hie	290	11	is	be	VBZ
cord-332422-s15o0hie	290	12	modulated	modulate	VBN
cord-332422-s15o0hie	290	13	by	by	IN
cord-332422-s15o0hie	290	14	specific	specific	JJ
cord-332422-s15o0hie	290	15	glycans	glycan	NNS
cord-332422-s15o0hie	290	16	on	on	IN
cord-332422-s15o0hie	290	17	the	the	DT
cord-332422-s15o0hie	290	18	E2	E2	NNP
cord-332422-s15o0hie	290	19	envelope	envelope	NN
cord-332422-s15o0hie	290	20	protein	protein	NN
cord-332422-s15o0hie	290	21	The	the	DT
cord-332422-s15o0hie	290	22	variable	variable	JJ
cord-332422-s15o0hie	290	23	regions	region	NNS
cord-332422-s15o0hie	290	24	of	of	IN
cord-332422-s15o0hie	290	25	hepatitis	hepatitis	NN
cord-332422-s15o0hie	290	26	C	C	NNP
cord-332422-s15o0hie	290	27	virus	virus	NN
cord-332422-s15o0hie	290	28	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	290	29	E2	E2	NNP
cord-332422-s15o0hie	290	30	have	have	VBP
cord-332422-s15o0hie	290	31	an	an	DT
cord-332422-s15o0hie	290	32	essential	essential	JJ
cord-332422-s15o0hie	290	33	structural	structural	JJ
cord-332422-s15o0hie	290	34	role	role	NN
cord-332422-s15o0hie	290	35	in	in	IN
cord-332422-s15o0hie	290	36	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	290	37	assembly	assembly	NN
cord-332422-s15o0hie	290	38	and	and	CC
cord-332422-s15o0hie	290	39	virion	virion	NN
cord-332422-s15o0hie	290	40	infectivity	infectivity	NN
cord-332422-s15o0hie	290	41	Role	role	NN
cord-332422-s15o0hie	290	42	of	of	IN
cord-332422-s15o0hie	290	43	N	n	NN
cord-332422-s15o0hie	290	44	-	-	HYPH
cord-332422-s15o0hie	290	45	linked	link	VBN
cord-332422-s15o0hie	290	46	glycans	glycan	NNS
cord-332422-s15o0hie	290	47	in	in	IN
cord-332422-s15o0hie	290	48	the	the	DT
cord-332422-s15o0hie	290	49	functions	function	NNS
cord-332422-s15o0hie	290	50	of	of	IN
cord-332422-s15o0hie	290	51	hepatitis	hepatitis	NN
cord-332422-s15o0hie	290	52	C	C	NNP
cord-332422-s15o0hie	290	53	virus	virus	NN
cord-332422-s15o0hie	290	54	envelope	envelope	NN
cord-332422-s15o0hie	290	55	proteins	protein	NNS
cord-332422-s15o0hie	290	56	incorporated	incorporate	VBN
cord-332422-s15o0hie	290	57	into	into	IN
cord-332422-s15o0hie	290	58	infectious	infectious	JJ
cord-332422-s15o0hie	290	59	virions	virion	NNS
cord-332422-s15o0hie	291	1	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	291	2	C	C	NNP
cord-332422-s15o0hie	291	3	virus	virus	NN
cord-332422-s15o0hie	291	4	particles	particle	NNS
cord-332422-s15o0hie	291	5	and	and	CC
cord-332422-s15o0hie	291	6	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	291	7	metabolism	metabolism	NN
cord-332422-s15o0hie	291	8	Biochemical	biochemical	JJ
cord-332422-s15o0hie	291	9	and	and	CC
cord-332422-s15o0hie	291	10	morphological	morphological	JJ
cord-332422-s15o0hie	291	11	properties	property	NNS
cord-332422-s15o0hie	291	12	of	of	IN
cord-332422-s15o0hie	291	13	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	14	C	C	NNP
cord-332422-s15o0hie	291	15	virus	virus	NN
cord-332422-s15o0hie	291	16	particles	particle	NNS
cord-332422-s15o0hie	291	17	and	and	CC
cord-332422-s15o0hie	291	18	determination	determination	NN
cord-332422-s15o0hie	291	19	of	of	IN
cord-332422-s15o0hie	291	20	their	-PRON-	PRP$
cord-332422-s15o0hie	291	21	lipidome	lipidome	NNP
cord-332422-s15o0hie	291	22	Lipoprotein	Lipoprotein	NNP
cord-332422-s15o0hie	291	23	lipase	lipase	NN
cord-332422-s15o0hie	291	24	mediates	mediate	VBZ
cord-332422-s15o0hie	291	25	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	26	C	C	NNP
cord-332422-s15o0hie	291	27	virus	virus	NN
cord-332422-s15o0hie	291	28	(	(	-LRB-
cord-332422-s15o0hie	291	29	HCV	HCV	NNP
cord-332422-s15o0hie	291	30	)	)	-RRB-
cord-332422-s15o0hie	291	31	cell	cell	NN
cord-332422-s15o0hie	291	32	entry	entry	NN
cord-332422-s15o0hie	291	33	and	and	CC
cord-332422-s15o0hie	291	34	inhibits	inhibit	VBZ
cord-332422-s15o0hie	291	35	HCV	HCV	NNP
cord-332422-s15o0hie	291	36	infection	infection	NN
cord-332422-s15o0hie	291	37	Lipoprotein	Lipoprotein	NNP
cord-332422-s15o0hie	291	38	lipase	lipase	NN
cord-332422-s15o0hie	291	39	and	and	CC
cord-332422-s15o0hie	291	40	hepatic	hepatic	JJ
cord-332422-s15o0hie	291	41	triglyceride	triglyceride	NN
cord-332422-s15o0hie	291	42	lipase	lipase	NN
cord-332422-s15o0hie	291	43	reduce	reduce	VB
cord-332422-s15o0hie	291	44	the	the	DT
cord-332422-s15o0hie	291	45	infectivity	infectivity	NN
cord-332422-s15o0hie	291	46	of	of	IN
cord-332422-s15o0hie	291	47	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	48	C	C	NNP
cord-332422-s15o0hie	291	49	virus	virus	NN
cord-332422-s15o0hie	291	50	(	(	-LRB-
cord-332422-s15o0hie	291	51	HCV	HCV	NNP
cord-332422-s15o0hie	291	52	)	)	-RRB-
cord-332422-s15o0hie	291	53	through	through	IN
cord-332422-s15o0hie	291	54	their	-PRON-	PRP$
cord-332422-s15o0hie	291	55	catalytic	catalytic	JJ
cord-332422-s15o0hie	291	56	activities	activity	NNS
cord-332422-s15o0hie	291	57	on	on	IN
cord-332422-s15o0hie	291	58	HCV	HCV	NNP
cord-332422-s15o0hie	291	59	-	-	HYPH
cord-332422-s15o0hie	291	60	associated	associate	VBN
cord-332422-s15o0hie	291	61	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	291	62	Human	Human	NNP
cord-332422-s15o0hie	291	63	apolipoprotein	apolipoprotein	NN
cord-332422-s15o0hie	291	64	e	e	NN
cord-332422-s15o0hie	291	65	is	be	VBZ
cord-332422-s15o0hie	291	66	required	require	VBN
cord-332422-s15o0hie	291	67	for	for	IN
cord-332422-s15o0hie	291	68	infectivity	infectivity	NN
cord-332422-s15o0hie	291	69	and	and	CC
cord-332422-s15o0hie	291	70	production	production	NN
cord-332422-s15o0hie	291	71	of	of	IN
cord-332422-s15o0hie	291	72	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	73	C	C	NNP
cord-332422-s15o0hie	291	74	virus	virus	NN
cord-332422-s15o0hie	291	75	in	in	IN
cord-332422-s15o0hie	291	76	cell	cell	NN
cord-332422-s15o0hie	291	77	culture	culture	NN
cord-332422-s15o0hie	291	78	Infectivity	infectivity	NN
cord-332422-s15o0hie	291	79	of	of	IN
cord-332422-s15o0hie	291	80	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	81	C	c	NN
cord-332422-s15o0hie	291	82	virus	virus	NN
cord-332422-s15o0hie	291	83	is	be	VBZ
cord-332422-s15o0hie	291	84	influenced	influence	VBN
cord-332422-s15o0hie	291	85	by	by	IN
cord-332422-s15o0hie	291	86	association	association	NNP
cord-332422-s15o0hie	291	87	with	with	IN
cord-332422-s15o0hie	291	88	apolipoprotein	apolipoprotein	NN
cord-332422-s15o0hie	291	89	E	E	NNP
cord-332422-s15o0hie	291	90	isoforms	isoform	NNS
cord-332422-s15o0hie	291	91	Apolipoprotein	Apolipoprotein	NNP
cord-332422-s15o0hie	291	92	c1	c1	NNP
cord-332422-s15o0hie	291	93	association	association	NN
cord-332422-s15o0hie	291	94	with	with	IN
cord-332422-s15o0hie	291	95	hepatitis	hepatitis	NNP
cord-332422-s15o0hie	291	96	C	C	NNP
cord-332422-s15o0hie	291	97	virus	virus	NN
cord-332422-s15o0hie	291	98	Early	early	JJ
cord-332422-s15o0hie	291	99	steps	step	NNS
cord-332422-s15o0hie	291	100	of	of	IN
cord-332422-s15o0hie	291	101	the	the	DT
cord-332422-s15o0hie	291	102	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	103	C	C	NNP
cord-332422-s15o0hie	291	104	virus	virus	NN
cord-332422-s15o0hie	291	105	life	life	NN
cord-332422-s15o0hie	291	106	cycle	cycle	NN
cord-332422-s15o0hie	291	107	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	291	108	C	C	NNP
cord-332422-s15o0hie	291	109	virus	virus	NN
cord-332422-s15o0hie	291	110	entry	entry	NN
cord-332422-s15o0hie	291	111	into	into	IN
cord-332422-s15o0hie	291	112	host	host	NN
cord-332422-s15o0hie	291	113	cells	cell	NNS
cord-332422-s15o0hie	291	114	Role	role	NN
cord-332422-s15o0hie	291	115	of	of	IN
cord-332422-s15o0hie	291	116	scavenger	scavenger	NN
cord-332422-s15o0hie	291	117	receptor	receptor	NN
cord-332422-s15o0hie	291	118	class	class	NN
cord-332422-s15o0hie	291	119	B	b	NN
cord-332422-s15o0hie	291	120	type	type	NN
cord-332422-s15o0hie	291	121	I	-PRON-	PRP
cord-332422-s15o0hie	291	122	in	in	IN
cord-332422-s15o0hie	291	123	hepatitis	hepatitis	NN
cord-332422-s15o0hie	291	124	C	C	NNP
cord-332422-s15o0hie	291	125	virus	virus	NN
cord-332422-s15o0hie	291	126	entry	entry	NN
cord-332422-s15o0hie	291	127	:	:	:
cord-332422-s15o0hie	291	128	kinetics	kinetics	NNP
cord-332422-s15o0hie	291	129	and	and	CC
cord-332422-s15o0hie	291	130	molecular	molecular	JJ
cord-332422-s15o0hie	291	131	determinants	determinant	NNS
cord-332422-s15o0hie	291	132	Receptor	Receptor	NNP
cord-332422-s15o0hie	291	133	complementation	complementation	NN
cord-332422-s15o0hie	291	134	and	and	CC
cord-332422-s15o0hie	291	135	mutagenesis	mutagenesis	NN
cord-332422-s15o0hie	291	136	reveal	reveal	VBP
cord-332422-s15o0hie	291	137	SR	SR	NNP
cord-332422-s15o0hie	291	138	-	-	HYPH
cord-332422-s15o0hie	291	139	BI	BI	NNP
cord-332422-s15o0hie	291	140	as	as	IN
cord-332422-s15o0hie	291	141	an	an	DT
cord-332422-s15o0hie	291	142	essential	essential	JJ
cord-332422-s15o0hie	291	143	HCV	HCV	NNP
cord-332422-s15o0hie	291	144	entry	entry	NN
cord-332422-s15o0hie	291	145	factor	factor	NN
cord-332422-s15o0hie	291	146	and	and	CC
cord-332422-s15o0hie	291	147	functionally	functionally	RB
cord-332422-s15o0hie	291	148	imply	imply	VB
cord-332422-s15o0hie	291	149	its	-PRON-	PRP$
cord-332422-s15o0hie	291	150	intra	intra	JJ
cord-332422-s15o0hie	291	151	-	-	JJ
cord-332422-s15o0hie	291	152	and	and	CC
cord-332422-s15o0hie	291	153	extracellular	extracellular	JJ
cord-332422-s15o0hie	291	154	domains	domain	NNS
cord-332422-s15o0hie	292	1	The	the	DT
cord-332422-s15o0hie	292	2	SR	SR	NNP
cord-332422-s15o0hie	292	3	-	-	HYPH
cord-332422-s15o0hie	292	4	BI	BI	NNP
cord-332422-s15o0hie	292	5	partner	partner	NN
cord-332422-s15o0hie	292	6	PDZK1	PDZK1	NNP
cord-332422-s15o0hie	292	7	facilitates	facilitate	VBZ
cord-332422-s15o0hie	292	8	hepatitis	hepatitis	NN
cord-332422-s15o0hie	292	9	C	C	NNP
cord-332422-s15o0hie	292	10	virus	virus	NN
cord-332422-s15o0hie	292	11	entry	entry	NN
cord-332422-s15o0hie	292	12	Scavenger	Scavenger	NNP
cord-332422-s15o0hie	292	13	receptor	receptor	NN
cord-332422-s15o0hie	292	14	class	class	NN
cord-332422-s15o0hie	292	15	B	b	NN
cord-332422-s15o0hie	292	16	type	type	NN
cord-332422-s15o0hie	293	1	I	-PRON-	PRP
cord-332422-s15o0hie	293	2	is	be	VBZ
cord-332422-s15o0hie	293	3	a	a	DT
cord-332422-s15o0hie	293	4	key	key	JJ
cord-332422-s15o0hie	293	5	host	host	NN
cord-332422-s15o0hie	293	6	factor	factor	NN
cord-332422-s15o0hie	293	7	for	for	IN
cord-332422-s15o0hie	293	8	hepatitis	hepatitis	NN
cord-332422-s15o0hie	293	9	C	C	NNP
cord-332422-s15o0hie	293	10	virus	virus	NN
cord-332422-s15o0hie	293	11	infection	infection	NN
cord-332422-s15o0hie	293	12	required	require	VBN
cord-332422-s15o0hie	293	13	for	for	IN
cord-332422-s15o0hie	293	14	an	an	DT
cord-332422-s15o0hie	293	15	entry	entry	NN
cord-332422-s15o0hie	293	16	step	step	NN
cord-332422-s15o0hie	293	17	closely	closely	RB
cord-332422-s15o0hie	293	18	linked	link	VBN
cord-332422-s15o0hie	293	19	to	to	IN
cord-332422-s15o0hie	293	20	CD81	CD81	NNP
cord-332422-s15o0hie	294	1	The	the	DT
cord-332422-s15o0hie	294	2	interaction	interaction	NN
cord-332422-s15o0hie	294	3	of	of	IN
cord-332422-s15o0hie	294	4	natural	natural	JJ
cord-332422-s15o0hie	294	5	hepatitis	hepatitis	NN
cord-332422-s15o0hie	294	6	C	C	NNP
cord-332422-s15o0hie	294	7	virus	virus	NN
cord-332422-s15o0hie	294	8	with	with	IN
cord-332422-s15o0hie	294	9	human	human	JJ
cord-332422-s15o0hie	294	10	scavenger	scavenger	NN
cord-332422-s15o0hie	294	11	receptor	receptor	NN
cord-332422-s15o0hie	294	12	SR	SR	NNP
cord-332422-s15o0hie	294	13	-	-	:
cord-332422-s15o0hie	294	14	BI/	BI/	NNP
cord-332422-s15o0hie	294	15	Cla1	Cla1	NNP
cord-332422-s15o0hie	294	16	is	be	VBZ
cord-332422-s15o0hie	294	17	mediated	mediate	VBN
cord-332422-s15o0hie	294	18	by	by	IN
cord-332422-s15o0hie	294	19	ApoB	ApoB	NNP
cord-332422-s15o0hie	294	20	-	-	HYPH
cord-332422-s15o0hie	294	21	containing	contain	VBG
cord-332422-s15o0hie	294	22	lipoproteins	lipoprotein	NNS
cord-332422-s15o0hie	294	23	A	a	DT
cord-332422-s15o0hie	294	24	genetically	genetically	RB
cord-332422-s15o0hie	294	25	humanized	humanize	VBN
cord-332422-s15o0hie	294	26	mouse	mouse	NN
cord-332422-s15o0hie	294	27	model	model	NN
cord-332422-s15o0hie	294	28	for	for	IN
cord-332422-s15o0hie	294	29	hepatitis	hepatitis	NN
cord-332422-s15o0hie	294	30	C	C	NNP
cord-332422-s15o0hie	294	31	virus	virus	NN
cord-332422-s15o0hie	294	32	infection	infection	NN
cord-332422-s15o0hie	294	33	Binding	Binding	NNP
cord-332422-s15o0hie	294	34	of	of	IN
cord-332422-s15o0hie	294	35	hepatitis	hepatitis	NN
cord-332422-s15o0hie	294	36	C	c	NN
cord-332422-s15o0hie	294	37	virus	virus	NN
cord-332422-s15o0hie	294	38	to	to	IN
cord-332422-s15o0hie	294	39	CD81	CD81	NNP
cord-332422-s15o0hie	294	40	CD81	CD81	NNP
cord-332422-s15o0hie	294	41	is	be	VBZ
cord-332422-s15o0hie	294	42	required	require	VBN
cord-332422-s15o0hie	294	43	for	for	IN
cord-332422-s15o0hie	294	44	hepatitis	hepatitis	NN
cord-332422-s15o0hie	294	45	C	C	NNP
cord-332422-s15o0hie	294	46	virus	virus	NN
cord-332422-s15o0hie	294	47	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	294	48	-	-	HYPH
cord-332422-s15o0hie	294	49	mediated	mediate	VBN
cord-332422-s15o0hie	294	50	viral	viral	JJ
cord-332422-s15o0hie	294	51	infection	infection	NN
cord-332422-s15o0hie	294	52	CD81	CD81	NNP
cord-332422-s15o0hie	294	53	extracellular	extracellular	JJ
cord-332422-s15o0hie	294	54	domain	domain	NN
cord-332422-s15o0hie	294	55	3D	3d	JJ
cord-332422-s15o0hie	294	56	structure	structure	NN
cord-332422-s15o0hie	294	57	:	:	:
cord-332422-s15o0hie	294	58	insight	insight	NN
cord-332422-s15o0hie	294	59	into	into	IN
cord-332422-s15o0hie	294	60	the	the	DT
cord-332422-s15o0hie	294	61	tetraspanin	tetraspanin	NNP
cord-332422-s15o0hie	294	62	superfamily	superfamily	NNP
cord-332422-s15o0hie	294	63	structural	structural	JJ
cord-332422-s15o0hie	294	64	motifs	motif	NNS
cord-332422-s15o0hie	295	1	CD81	CD81	NNP
cord-332422-s15o0hie	295	2	expression	expression	NN
cord-332422-s15o0hie	295	3	is	be	VBZ
cord-332422-s15o0hie	295	4	important	important	JJ
cord-332422-s15o0hie	295	5	for	for	IN
cord-332422-s15o0hie	295	6	the	the	DT
cord-332422-s15o0hie	295	7	permissiveness	permissiveness	NN
cord-332422-s15o0hie	295	8	of	of	IN
cord-332422-s15o0hie	295	9	Huh7	Huh7	NNP
cord-332422-s15o0hie	295	10	cell	cell	NN
cord-332422-s15o0hie	295	11	clones	clone	NNS
cord-332422-s15o0hie	295	12	for	for	IN
cord-332422-s15o0hie	295	13	heterogeneous	heterogeneous	JJ
cord-332422-s15o0hie	295	14	hepatitis	hepatitis	NN
cord-332422-s15o0hie	295	15	C	c	NN
cord-332422-s15o0hie	295	16	virus	virus	NN
cord-332422-s15o0hie	295	17	infection	infection	NN
cord-332422-s15o0hie	296	1	The	the	DT
cord-332422-s15o0hie	296	2	level	level	NN
cord-332422-s15o0hie	296	3	of	of	IN
cord-332422-s15o0hie	296	4	CD81	CD81	NNP
cord-332422-s15o0hie	296	5	cell	cell	NN
cord-332422-s15o0hie	296	6	surface	surface	NN
cord-332422-s15o0hie	296	7	expression	expression	NN
cord-332422-s15o0hie	296	8	is	be	VBZ
cord-332422-s15o0hie	296	9	a	a	DT
cord-332422-s15o0hie	296	10	key	key	JJ
cord-332422-s15o0hie	296	11	determinant	determinant	NN
cord-332422-s15o0hie	296	12	for	for	IN
cord-332422-s15o0hie	296	13	productive	productive	JJ
cord-332422-s15o0hie	296	14	entry	entry	NN
cord-332422-s15o0hie	296	15	of	of	IN
cord-332422-s15o0hie	296	16	hepatitis	hepatitis	NN
cord-332422-s15o0hie	296	17	C	C	NNP
cord-332422-s15o0hie	296	18	virus	virus	NN
cord-332422-s15o0hie	296	19	into	into	IN
cord-332422-s15o0hie	296	20	host	host	NN
cord-332422-s15o0hie	296	21	cells	cell	NNS
cord-332422-s15o0hie	296	22	Initiation	initiation	NN
cord-332422-s15o0hie	296	23	of	of	IN
cord-332422-s15o0hie	296	24	hepatitis	hepatitis	NN
cord-332422-s15o0hie	296	25	C	C	NNP
cord-332422-s15o0hie	296	26	virus	virus	NN
cord-332422-s15o0hie	296	27	infection	infection	NN
cord-332422-s15o0hie	296	28	requires	require	VBZ
cord-332422-s15o0hie	296	29	the	the	DT
cord-332422-s15o0hie	296	30	dynamic	dynamic	JJ
cord-332422-s15o0hie	296	31	microtubule	microtubule	NN
cord-332422-s15o0hie	296	32	network	network	NN
cord-332422-s15o0hie	296	33	:	:	:
cord-332422-s15o0hie	296	34	role	role	NN
cord-332422-s15o0hie	296	35	of	of	IN
cord-332422-s15o0hie	296	36	the	the	DT
cord-332422-s15o0hie	296	37	viral	viral	JJ
cord-332422-s15o0hie	296	38	nucleocapsid	nucleocapsid	NNP
cord-332422-s15o0hie	296	39	protein	protein	NNP
cord-332422-s15o0hie	297	1	The	the	DT
cord-332422-s15o0hie	297	2	association	association	NN
cord-332422-s15o0hie	297	3	of	of	IN
cord-332422-s15o0hie	297	4	CD81	CD81	NNP
cord-332422-s15o0hie	297	5	with	with	IN
cord-332422-s15o0hie	297	6	tetraspanin	tetraspanin	NN
cord-332422-s15o0hie	297	7	-	-	HYPH
cord-332422-s15o0hie	297	8	enriched	enrich	VBN
cord-332422-s15o0hie	297	9	microdomains	microdomain	NNS
cord-332422-s15o0hie	297	10	is	be	VBZ
cord-332422-s15o0hie	297	11	not	not	RB
cord-332422-s15o0hie	297	12	essential	essential	JJ
cord-332422-s15o0hie	297	13	for	for	IN
cord-332422-s15o0hie	297	14	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	297	15	C	C	NNP
cord-332422-s15o0hie	297	16	virus	virus	NN
cord-332422-s15o0hie	297	17	entry	entry	NN
cord-332422-s15o0hie	297	18	Cholesterol	cholesterol	NN
cord-332422-s15o0hie	297	19	contributes	contribute	VBZ
cord-332422-s15o0hie	297	20	to	to	IN
cord-332422-s15o0hie	297	21	the	the	DT
cord-332422-s15o0hie	297	22	organization	organization	NN
cord-332422-s15o0hie	297	23	of	of	IN
cord-332422-s15o0hie	297	24	tetraspaninenriched	tetraspaninenriched	NNP
cord-332422-s15o0hie	297	25	microdomains	microdomains	NNP
cord-332422-s15o0hie	297	26	and	and	CC
cord-332422-s15o0hie	297	27	to	to	IN
cord-332422-s15o0hie	297	28	CD81-dependent	cd81-dependent	CD
cord-332422-s15o0hie	297	29	infection	infection	NN
cord-332422-s15o0hie	297	30	by	by	IN
cord-332422-s15o0hie	297	31	malaria	malaria	NN
cord-332422-s15o0hie	297	32	sporozoites	sporozoite	NNS
cord-332422-s15o0hie	298	1	The	the	DT
cord-332422-s15o0hie	298	2	CD81	CD81	NNP
cord-332422-s15o0hie	298	3	partner	partner	NN
cord-332422-s15o0hie	298	4	EWI-2wint	ewi-2wint	NN
cord-332422-s15o0hie	298	5	inhibits	inhibit	VBZ
cord-332422-s15o0hie	298	6	hepatitis	hepatitis	NN
cord-332422-s15o0hie	298	7	C	C	NNP
cord-332422-s15o0hie	298	8	virus	virus	NN
cord-332422-s15o0hie	298	9	entry	entry	NN
cord-332422-s15o0hie	298	10	Interacting	interact	VBG
cord-332422-s15o0hie	298	11	regions	region	NNS
cord-332422-s15o0hie	298	12	of	of	IN
cord-332422-s15o0hie	298	13	CD81	CD81	NNP
cord-332422-s15o0hie	298	14	and	and	CC
cord-332422-s15o0hie	298	15	two	two	CD
cord-332422-s15o0hie	298	16	of	of	IN
cord-332422-s15o0hie	298	17	its	-PRON-	PRP$
cord-332422-s15o0hie	298	18	partners	partner	NNS
cord-332422-s15o0hie	298	19	,	,	,
cord-332422-s15o0hie	298	20	EWI-2	EWI-2	NNP
cord-332422-s15o0hie	298	21	and	and	CC
cord-332422-s15o0hie	298	22	EWI-2wint	EWI-2wint	NNP
cord-332422-s15o0hie	298	23	and	and	CC
cord-332422-s15o0hie	298	24	their	-PRON-	PRP$
cord-332422-s15o0hie	298	25	effect	effect	NN
cord-332422-s15o0hie	298	26	on	on	IN
cord-332422-s15o0hie	298	27	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	298	28	C	C	NNP
cord-332422-s15o0hie	298	29	Virus	virus	NN
cord-332422-s15o0hie	298	30	infection	infection	NN
cord-332422-s15o0hie	298	31	Multifunctional	Multifunctional	NNP
cord-332422-s15o0hie	298	32	strands	strand	NNS
cord-332422-s15o0hie	298	33	in	in	IN
cord-332422-s15o0hie	298	34	tight	tight	JJ
cord-332422-s15o0hie	298	35	junctions	junction	NNS
cord-332422-s15o0hie	298	36	Molecular	molecular	JJ
cord-332422-s15o0hie	298	37	basis	basis	NN
cord-332422-s15o0hie	298	38	of	of	IN
cord-332422-s15o0hie	298	39	the	the	DT
cord-332422-s15o0hie	298	40	core	core	NN
cord-332422-s15o0hie	298	41	structure	structure	NN
cord-332422-s15o0hie	298	42	of	of	IN
cord-332422-s15o0hie	298	43	tight	tight	JJ
cord-332422-s15o0hie	298	44	junctions	junction	NNS
cord-332422-s15o0hie	298	45	Claudin-1	Claudin-1	NNP
cord-332422-s15o0hie	298	46	is	be	VBZ
cord-332422-s15o0hie	298	47	a	a	DT
cord-332422-s15o0hie	298	48	hepatitis	hepatitis	NN
cord-332422-s15o0hie	298	49	C	C	NNP
cord-332422-s15o0hie	298	50	virus	virus	NN
cord-332422-s15o0hie	298	51	co	co	NN
cord-332422-s15o0hie	298	52	-	-	NN
cord-332422-s15o0hie	298	53	receptor	receptor	NN
cord-332422-s15o0hie	298	54	required	require	VBN
cord-332422-s15o0hie	298	55	for	for	IN
cord-332422-s15o0hie	298	56	a	a	DT
cord-332422-s15o0hie	298	57	late	late	JJ
cord-332422-s15o0hie	298	58	step	step	NN
cord-332422-s15o0hie	298	59	in	in	IN
cord-332422-s15o0hie	298	60	entry	entry	NN
cord-332422-s15o0hie	298	61	Human	human	JJ
cord-332422-s15o0hie	298	62	occludin	occludin	NN
cord-332422-s15o0hie	298	63	is	be	VBZ
cord-332422-s15o0hie	298	64	a	a	DT
cord-332422-s15o0hie	298	65	hepatitis	hepatitis	NN
cord-332422-s15o0hie	298	66	C	c	NN
cord-332422-s15o0hie	298	67	virus	virus	NN
cord-332422-s15o0hie	298	68	entry	entry	NN
cord-332422-s15o0hie	298	69	factor	factor	NN
cord-332422-s15o0hie	298	70	required	require	VBN
cord-332422-s15o0hie	298	71	for	for	IN
cord-332422-s15o0hie	298	72	infection	infection	NN
cord-332422-s15o0hie	298	73	of	of	IN
cord-332422-s15o0hie	298	74	mouse	mouse	NN
cord-332422-s15o0hie	298	75	cells	cell	NNS
cord-332422-s15o0hie	298	76	Monoclonal	Monoclonal	NNP
cord-332422-s15o0hie	298	77	anti	anti	JJ
cord-332422-s15o0hie	298	78	-	-	JJ
cord-332422-s15o0hie	298	79	claudin	claudin	JJ
cord-332422-s15o0hie	298	80	1	1	CD
cord-332422-s15o0hie	298	81	antibodies	antibody	NNS
cord-332422-s15o0hie	298	82	prevent	prevent	VBP
cord-332422-s15o0hie	298	83	hepatitis	hepatitis	NN
cord-332422-s15o0hie	298	84	C	c	NN
cord-332422-s15o0hie	298	85	virus	virus	NN
cord-332422-s15o0hie	298	86	infection	infection	NN
cord-332422-s15o0hie	298	87	of	of	IN
cord-332422-s15o0hie	298	88	primary	primary	JJ
cord-332422-s15o0hie	298	89	human	human	JJ
cord-332422-s15o0hie	298	90	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	298	91	Claudin-6	Claudin-6	NNPS
cord-332422-s15o0hie	298	92	and	and	CC
cord-332422-s15o0hie	298	93	claudin-9	claudin-9	NNP
cord-332422-s15o0hie	298	94	function	function	NN
cord-332422-s15o0hie	298	95	as	as	IN
cord-332422-s15o0hie	298	96	additional	additional	JJ
cord-332422-s15o0hie	298	97	coreceptors	coreceptor	NNS
cord-332422-s15o0hie	298	98	for	for	IN
cord-332422-s15o0hie	298	99	hepatitis	hepatitis	NN
cord-332422-s15o0hie	298	100	C	C	NNP
cord-332422-s15o0hie	298	101	virus	virus	NN
cord-332422-s15o0hie	299	1	The	the	DT
cord-332422-s15o0hie	299	2	tight	tight	JJ
cord-332422-s15o0hie	299	3	junction	junction	NN
cord-332422-s15o0hie	299	4	proteins	protein	NNS
cord-332422-s15o0hie	299	5	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	299	6	,	,	,
cord-332422-s15o0hie	299	7	-6	-6	NNP
cord-332422-s15o0hie	299	8	,	,	,
cord-332422-s15o0hie	299	9	and	and	CC
cord-332422-s15o0hie	299	10	-9	-9	NNP
cord-332422-s15o0hie	299	11	are	be	VBP
cord-332422-s15o0hie	299	12	entry	entry	NN
cord-332422-s15o0hie	299	13	cofactors	cofactor	NNS
cord-332422-s15o0hie	299	14	for	for	IN
cord-332422-s15o0hie	299	15	hepatitis	hepatitis	NN
cord-332422-s15o0hie	299	16	C	C	NNP
cord-332422-s15o0hie	299	17	virus	virus	NN
cord-332422-s15o0hie	299	18	Residues	residue	NNS
cord-332422-s15o0hie	299	19	in	in	IN
cord-332422-s15o0hie	299	20	a	a	DT
cord-332422-s15o0hie	299	21	highly	highly	RB
cord-332422-s15o0hie	299	22	conserved	conserve	VBN
cord-332422-s15o0hie	299	23	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	299	24	motif	motif	NN
cord-332422-s15o0hie	299	25	are	be	VBP
cord-332422-s15o0hie	299	26	required	require	VBN
cord-332422-s15o0hie	299	27	for	for	IN
cord-332422-s15o0hie	299	28	hepatitis	hepatitis	NN
cord-332422-s15o0hie	299	29	C	C	NNP
cord-332422-s15o0hie	299	30	virus	virus	NN
cord-332422-s15o0hie	299	31	entry	entry	NN
cord-332422-s15o0hie	299	32	and	and	CC
cord-332422-s15o0hie	299	33	mediate	mediate	VB
cord-332422-s15o0hie	299	34	the	the	DT
cord-332422-s15o0hie	299	35	formation	formation	NN
cord-332422-s15o0hie	299	36	of	of	IN
cord-332422-s15o0hie	299	37	cell	cell	NN
cord-332422-s15o0hie	299	38	-	-	HYPH
cord-332422-s15o0hie	299	39	cell	cell	NN
cord-332422-s15o0hie	299	40	contacts	contact	NNS
cord-332422-s15o0hie	299	41	Mouse	mouse	NN
cord-332422-s15o0hie	299	42	-	-	HYPH
cord-332422-s15o0hie	299	43	specific	specific	JJ
cord-332422-s15o0hie	299	44	residues	residue	NNS
cord-332422-s15o0hie	299	45	of	of	IN
cord-332422-s15o0hie	299	46	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	299	47	limit	limit	NN
cord-332422-s15o0hie	299	48	hepatitis	hepatitis	NN
cord-332422-s15o0hie	299	49	C	c	NN
cord-332422-s15o0hie	299	50	virus	virus	NN
cord-332422-s15o0hie	299	51	genotype	genotype	NN
cord-332422-s15o0hie	299	52	2a	2a	CD
cord-332422-s15o0hie	299	53	infection	infection	NN
cord-332422-s15o0hie	299	54	in	in	IN
cord-332422-s15o0hie	299	55	a	a	DT
cord-332422-s15o0hie	299	56	human	human	JJ
cord-332422-s15o0hie	299	57	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	299	58	cell	cell	NN
cord-332422-s15o0hie	299	59	line	line	NN
cord-332422-s15o0hie	300	1	The	the	DT
cord-332422-s15o0hie	300	2	tight	tight	JJ
cord-332422-s15o0hie	300	3	junction	junction	NN
cord-332422-s15o0hie	300	4	-	-	HYPH
cord-332422-s15o0hie	300	5	associated	associate	VBN
cord-332422-s15o0hie	300	6	protein	protein	NN
cord-332422-s15o0hie	300	7	occludin	occludin	NNP
cord-332422-s15o0hie	300	8	is	be	VBZ
cord-332422-s15o0hie	300	9	required	require	VBN
cord-332422-s15o0hie	300	10	for	for	IN
cord-332422-s15o0hie	300	11	a	a	DT
cord-332422-s15o0hie	300	12	postbinding	postbinde	VBG
cord-332422-s15o0hie	300	13	step	step	NN
cord-332422-s15o0hie	300	14	in	in	IN
cord-332422-s15o0hie	300	15	hepatitis	hepatitis	NN
cord-332422-s15o0hie	300	16	C	C	NNP
cord-332422-s15o0hie	300	17	virus	virus	NN
cord-332422-s15o0hie	300	18	entry	entry	NN
cord-332422-s15o0hie	300	19	and	and	CC
cord-332422-s15o0hie	300	20	infection	infection	NN
cord-332422-s15o0hie	300	21	Tight	tight	JJ
cord-332422-s15o0hie	300	22	junction	junction	NN
cord-332422-s15o0hie	300	23	proteins	protein	NNS
cord-332422-s15o0hie	300	24	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	300	25	and	and	CC
cord-332422-s15o0hie	300	26	occludin	occludin	NNP
cord-332422-s15o0hie	301	1	control	control	NNP
cord-332422-s15o0hie	301	2	hepatitis	hepatitis	NNP
cord-332422-s15o0hie	301	3	C	C	NNP
cord-332422-s15o0hie	301	4	virus	virus	NN
cord-332422-s15o0hie	301	5	entry	entry	NN
cord-332422-s15o0hie	301	6	and	and	CC
cord-332422-s15o0hie	301	7	are	be	VBP
cord-332422-s15o0hie	301	8	downregulated	downregulate	VBN
cord-332422-s15o0hie	301	9	during	during	IN
cord-332422-s15o0hie	301	10	infection	infection	NN
cord-332422-s15o0hie	301	11	to	to	TO
cord-332422-s15o0hie	301	12	prevent	prevent	VB
cord-332422-s15o0hie	301	13	superinfection	superinfection	NN
cord-332422-s15o0hie	301	14	Speciesspecific	Speciesspecific	NNP
cord-332422-s15o0hie	301	15	regions	region	NNS
cord-332422-s15o0hie	301	16	of	of	IN
cord-332422-s15o0hie	301	17	occludin	occludin	NNS
cord-332422-s15o0hie	301	18	required	require	VBN
cord-332422-s15o0hie	301	19	by	by	IN
cord-332422-s15o0hie	301	20	hepatitis	hepatitis	NN
cord-332422-s15o0hie	301	21	C	C	NNP
cord-332422-s15o0hie	301	22	virus	virus	NN
cord-332422-s15o0hie	301	23	for	for	IN
cord-332422-s15o0hie	301	24	cell	cell	NN
cord-332422-s15o0hie	301	25	entry	entry	NN
cord-332422-s15o0hie	301	26	Glucocorticosteroids	Glucocorticosteroids	NNP
cord-332422-s15o0hie	301	27	increase	increase	VBP
cord-332422-s15o0hie	301	28	cell	cell	NN
cord-332422-s15o0hie	301	29	entry	entry	NN
cord-332422-s15o0hie	301	30	by	by	IN
cord-332422-s15o0hie	301	31	hepatitis	hepatitis	NN
cord-332422-s15o0hie	301	32	C	C	NNP
cord-332422-s15o0hie	301	33	virus	virus	NN
cord-332422-s15o0hie	301	34	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	301	35	C	C	NNP
cord-332422-s15o0hie	301	36	virus	virus	NN
cord-332422-s15o0hie	301	37	envelope	envelope	NN
cord-332422-s15o0hie	301	38	components	component	NNS
cord-332422-s15o0hie	301	39	alter	alter	VBP
cord-332422-s15o0hie	301	40	localization	localization	NN
cord-332422-s15o0hie	301	41	of	of	IN
cord-332422-s15o0hie	301	42	hepatocyte	hepatocyte	NN
cord-332422-s15o0hie	301	43	tight	tight	JJ
cord-332422-s15o0hie	301	44	junctionassociated	junctionassociated	JJ
cord-332422-s15o0hie	301	45	proteins	protein	NNS
cord-332422-s15o0hie	301	46	and	and	CC
cord-332422-s15o0hie	301	47	promote	promote	VB
cord-332422-s15o0hie	301	48	occludin	occludin	JJ
cord-332422-s15o0hie	301	49	retention	retention	NN
cord-332422-s15o0hie	301	50	in	in	IN
cord-332422-s15o0hie	301	51	the	the	DT
cord-332422-s15o0hie	301	52	endoplasmic	endoplasmic	NN
cord-332422-s15o0hie	301	53	reticulum	reticulum	NN
cord-332422-s15o0hie	301	54	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	301	55	C	C	NNP
cord-332422-s15o0hie	301	56	virus	virus	NN
cord-332422-s15o0hie	301	57	entry	entry	NN
cord-332422-s15o0hie	301	58	into	into	IN
cord-332422-s15o0hie	301	59	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	301	60	:	:	:
cord-332422-s15o0hie	301	61	Molecular	molecular	JJ
cord-332422-s15o0hie	301	62	mechanisms	mechanism	NNS
cord-332422-s15o0hie	301	63	and	and	CC
cord-332422-s15o0hie	301	64	targets	target	NNS
cord-332422-s15o0hie	301	65	for	for	IN
cord-332422-s15o0hie	301	66	antiviral	antiviral	JJ
cord-332422-s15o0hie	301	67	therapies	therapy	NNS
cord-332422-s15o0hie	302	1	The	the	DT
cord-332422-s15o0hie	302	2	lowdensity	lowdensity	NN
cord-332422-s15o0hie	302	3	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	302	4	receptor	receptor	NN
cord-332422-s15o0hie	302	5	plays	play	VBZ
cord-332422-s15o0hie	302	6	a	a	DT
cord-332422-s15o0hie	302	7	role	role	NN
cord-332422-s15o0hie	302	8	in	in	IN
cord-332422-s15o0hie	302	9	the	the	DT
cord-332422-s15o0hie	302	10	infection	infection	NN
cord-332422-s15o0hie	302	11	of	of	IN
cord-332422-s15o0hie	302	12	primary	primary	JJ
cord-332422-s15o0hie	302	13	human	human	JJ
cord-332422-s15o0hie	302	14	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	302	15	by	by	IN
cord-332422-s15o0hie	302	16	hepatitis	hepatitis	NN
cord-332422-s15o0hie	302	17	C	C	NNP
cord-332422-s15o0hie	302	18	virus	virus	NN
cord-332422-s15o0hie	302	19	Apolipoprotein	Apolipoprotein	NNP
cord-332422-s15o0hie	302	20	E	E	NNP
cord-332422-s15o0hie	302	21	on	on	IN
cord-332422-s15o0hie	302	22	hepatitis	hepatitis	NN
cord-332422-s15o0hie	302	23	C	c	NN
cord-332422-s15o0hie	302	24	virion	virion	NN
cord-332422-s15o0hie	302	25	facilitates	facilitate	VBZ
cord-332422-s15o0hie	302	26	infection	infection	NN
cord-332422-s15o0hie	302	27	through	through	IN
cord-332422-s15o0hie	302	28	interaction	interaction	NN
cord-332422-s15o0hie	302	29	with	with	IN
cord-332422-s15o0hie	302	30	low	low	JJ
cord-332422-s15o0hie	302	31	-	-	HYPH
cord-332422-s15o0hie	302	32	density	density	NN
cord-332422-s15o0hie	302	33	lipoprotein	lipoprotein	NN
cord-332422-s15o0hie	302	34	receptor	receptor	NN
cord-332422-s15o0hie	302	35	CD81	CD81	NNP
cord-332422-s15o0hie	302	36	and	and	CC
cord-332422-s15o0hie	302	37	claudin	claudin	NNP
cord-332422-s15o0hie	302	38	1	1	CD
cord-332422-s15o0hie	302	39	coreceptor	coreceptor	NNP
cord-332422-s15o0hie	302	40	association	association	NNP
cord-332422-s15o0hie	302	41	:	:	:
cord-332422-s15o0hie	303	1	role	role	NN
cord-332422-s15o0hie	303	2	in	in	IN
cord-332422-s15o0hie	303	3	hepatitis	hepatitis	NNP
cord-332422-s15o0hie	303	4	C	C	NNP
cord-332422-s15o0hie	303	5	virus	virus	NN
cord-332422-s15o0hie	303	6	entry	entry	NN
cord-332422-s15o0hie	303	7	Claudin	Claudin	NNP
cord-332422-s15o0hie	303	8	association	association	NN
cord-332422-s15o0hie	303	9	with	with	IN
cord-332422-s15o0hie	303	10	CD81	CD81	NNP
cord-332422-s15o0hie	303	11	defines	define	VBZ
cord-332422-s15o0hie	303	12	hepatitis	hepatitis	NN
cord-332422-s15o0hie	303	13	C	C	NNP
cord-332422-s15o0hie	303	14	virus	virus	NN
cord-332422-s15o0hie	303	15	entry	entry	NN
cord-332422-s15o0hie	303	16	Inhibition	inhibition	NN
cord-332422-s15o0hie	303	17	of	of	IN
cord-332422-s15o0hie	303	18	hepatitis	hepatitis	NN
cord-332422-s15o0hie	303	19	C	C	NNP
cord-332422-s15o0hie	303	20	virus	virus	NN
cord-332422-s15o0hie	303	21	infection	infection	NN
cord-332422-s15o0hie	303	22	by	by	IN
cord-332422-s15o0hie	303	23	anti	anti	JJ
cord-332422-s15o0hie	303	24	-	-	JJ
cord-332422-s15o0hie	303	25	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	303	26	antibodies	antibody	NNS
cord-332422-s15o0hie	303	27	is	be	VBZ
cord-332422-s15o0hie	303	28	mediated	mediate	VBN
cord-332422-s15o0hie	303	29	by	by	IN
cord-332422-s15o0hie	303	30	neutralization	neutralization	NN
cord-332422-s15o0hie	303	31	of	of	IN
cord-332422-s15o0hie	303	32	E2-CD81-claudin-1	E2-CD81-claudin-1	NNP
cord-332422-s15o0hie	303	33	associations	association	NNS
cord-332422-s15o0hie	303	34	EGFR	EGFR	NNP
cord-332422-s15o0hie	303	35	and	and	CC
cord-332422-s15o0hie	303	36	EphA2	EphA2	NNP
cord-332422-s15o0hie	304	1	are	be	VBP
cord-332422-s15o0hie	304	2	host	host	NN
cord-332422-s15o0hie	304	3	factors	factor	NNS
cord-332422-s15o0hie	304	4	for	for	IN
cord-332422-s15o0hie	304	5	hepatitis	hepatitis	NN
cord-332422-s15o0hie	304	6	C	C	NNP
cord-332422-s15o0hie	304	7	virus	virus	NN
cord-332422-s15o0hie	304	8	entry	entry	NN
cord-332422-s15o0hie	304	9	and	and	CC
cord-332422-s15o0hie	304	10	possible	possible	JJ
cord-332422-s15o0hie	304	11	targets	target	NNS
cord-332422-s15o0hie	304	12	for	for	IN
cord-332422-s15o0hie	304	13	antiviral	antiviral	JJ
cord-332422-s15o0hie	304	14	therapy	therapy	NN
cord-332422-s15o0hie	304	15	RNA	RNA	NNP
cord-332422-s15o0hie	304	16	interference	interference	NN
cord-332422-s15o0hie	304	17	and	and	CC
cord-332422-s15o0hie	304	18	single	single	JJ
cord-332422-s15o0hie	304	19	particle	particle	NN
cord-332422-s15o0hie	304	20	tracking	tracking	NN
cord-332422-s15o0hie	304	21	analysis	analysis	NN
cord-332422-s15o0hie	304	22	of	of	IN
cord-332422-s15o0hie	304	23	hepatitis	hepatitis	NN
cord-332422-s15o0hie	304	24	C	C	NNP
cord-332422-s15o0hie	304	25	virus	virus	NN
cord-332422-s15o0hie	304	26	endocytosis	endocytosis	NN
cord-332422-s15o0hie	304	27	CD81	CD81	NNP
cord-332422-s15o0hie	304	28	is	be	VBZ
cord-332422-s15o0hie	304	29	a	a	DT
cord-332422-s15o0hie	304	30	central	central	JJ
cord-332422-s15o0hie	304	31	regulator	regulator	NN
cord-332422-s15o0hie	304	32	of	of	IN
cord-332422-s15o0hie	304	33	cellular	cellular	JJ
cord-332422-s15o0hie	304	34	events	event	NNS
cord-332422-s15o0hie	304	35	required	require	VBN
cord-332422-s15o0hie	304	36	for	for	IN
cord-332422-s15o0hie	304	37	hepatitis	hepatitis	NN
cord-332422-s15o0hie	304	38	C	C	NNP
cord-332422-s15o0hie	304	39	virus	virus	NN
cord-332422-s15o0hie	304	40	infection	infection	NN
cord-332422-s15o0hie	304	41	of	of	IN
cord-332422-s15o0hie	304	42	human	human	JJ
cord-332422-s15o0hie	304	43	hepatocytes	hepatocyte	NNS
cord-332422-s15o0hie	304	44	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	304	45	C	C	NNP
cord-332422-s15o0hie	304	46	virus	virus	NN
cord-332422-s15o0hie	304	47	entry	entry	NN
cord-332422-s15o0hie	304	48	depends	depend	VBZ
cord-332422-s15o0hie	304	49	on	on	IN
cord-332422-s15o0hie	304	50	clathrin	clathrin	NN
cord-332422-s15o0hie	304	51	-	-	HYPH
cord-332422-s15o0hie	304	52	mediated	mediate	VBN
cord-332422-s15o0hie	304	53	endocytosis	endocytosis	NN
cord-332422-s15o0hie	304	54	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	304	55	C	C	NNP
cord-332422-s15o0hie	304	56	virus	virus	NN
cord-332422-s15o0hie	304	57	entry	entry	NN
cord-332422-s15o0hie	305	1	requires	require	VBZ
cord-332422-s15o0hie	305	2	a	a	DT
cord-332422-s15o0hie	305	3	critical	critical	JJ
cord-332422-s15o0hie	305	4	postinternalization	postinternalization	NN
cord-332422-s15o0hie	305	5	step	step	NN
cord-332422-s15o0hie	305	6	and	and	CC
cord-332422-s15o0hie	305	7	delivery	delivery	NN
cord-332422-s15o0hie	305	8	to	to	IN
cord-332422-s15o0hie	305	9	early	early	JJ
cord-332422-s15o0hie	305	10	endosomes	endosome	NNS
cord-332422-s15o0hie	305	11	via	via	IN
cord-332422-s15o0hie	305	12	clathrincoated	clathrincoate	VBN
cord-332422-s15o0hie	305	13	vesicles	vesicle	NNS
cord-332422-s15o0hie	305	14	Listeria	Listeria	NNP
cord-332422-s15o0hie	305	15	hijacks	hijack	VBZ
cord-332422-s15o0hie	305	16	the	the	DT
cord-332422-s15o0hie	305	17	clathrindependent	clathrindependent	NN
cord-332422-s15o0hie	305	18	endocytic	endocytic	JJ
cord-332422-s15o0hie	305	19	machinery	machinery	NN
cord-332422-s15o0hie	305	20	to	to	TO
cord-332422-s15o0hie	305	21	invade	invade	VB
cord-332422-s15o0hie	305	22	mammalian	mammalian	JJ
cord-332422-s15o0hie	305	23	cells	cell	NNS
cord-332422-s15o0hie	305	24	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	305	25	C	C	NNP
cord-332422-s15o0hie	305	26	virus	virus	NN
cord-332422-s15o0hie	305	27	receptor	receptor	NN
cord-332422-s15o0hie	305	28	expression	expression	NN
cord-332422-s15o0hie	305	29	in	in	IN
cord-332422-s15o0hie	305	30	normal	normal	JJ
cord-332422-s15o0hie	305	31	and	and	CC
cord-332422-s15o0hie	305	32	diseased	diseased	JJ
cord-332422-s15o0hie	305	33	liver	liver	NN
cord-332422-s15o0hie	305	34	tissue	tissue	NN
cord-332422-s15o0hie	305	35	Polarization	polarization	NN
cord-332422-s15o0hie	305	36	restricts	restrict	VBZ
cord-332422-s15o0hie	305	37	hepatitis	hepatitis	NN
cord-332422-s15o0hie	305	38	C	c	NN
cord-332422-s15o0hie	305	39	virus	virus	NN
cord-332422-s15o0hie	305	40	entry	entry	NN
cord-332422-s15o0hie	305	41	into	into	IN
cord-332422-s15o0hie	305	42	HepG2	HepG2	NNP
cord-332422-s15o0hie	305	43	hepatoma	hepatoma	NN
cord-332422-s15o0hie	305	44	cells	cell	NNS
cord-332422-s15o0hie	306	1	Hepatoma	Hepatoma	NNP
cord-332422-s15o0hie	306	2	cell	cell	NN
cord-332422-s15o0hie	306	3	density	density	NN
cord-332422-s15o0hie	306	4	promotes	promote	VBZ
cord-332422-s15o0hie	306	5	claudin-1	claudin-1	NNP
cord-332422-s15o0hie	306	6	and	and	CC
cord-332422-s15o0hie	306	7	scavenger	scavenger	NN
cord-332422-s15o0hie	306	8	receptor	receptor	NN
cord-332422-s15o0hie	306	9	BI	BI	NNP
cord-332422-s15o0hie	306	10	expression	expression	NN
cord-332422-s15o0hie	306	11	and	and	CC
cord-332422-s15o0hie	306	12	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	13	C	C	NNP
cord-332422-s15o0hie	306	14	virus	virus	NN
cord-332422-s15o0hie	306	15	internalization	internalization	NN
cord-332422-s15o0hie	306	16	Effect	effect	NN
cord-332422-s15o0hie	306	17	of	of	IN
cord-332422-s15o0hie	306	18	cell	cell	NN
cord-332422-s15o0hie	306	19	polarization	polarization	NN
cord-332422-s15o0hie	306	20	on	on	IN
cord-332422-s15o0hie	306	21	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	22	C	C	NNP
cord-332422-s15o0hie	306	23	virus	virus	NN
cord-332422-s15o0hie	306	24	entry	entry	NN
cord-332422-s15o0hie	306	25	Hepatitis	Hepatitis	NNP
cord-332422-s15o0hie	306	26	C	C	NNP
cord-332422-s15o0hie	306	27	virus	virus	NN
cord-332422-s15o0hie	306	28	cellcell	cellcell	NN
cord-332422-s15o0hie	306	29	transmission	transmission	NN
cord-332422-s15o0hie	306	30	in	in	IN
cord-332422-s15o0hie	306	31	hepatoma	hepatoma	NNP
cord-332422-s15o0hie	306	32	cells	cell	NNS
cord-332422-s15o0hie	306	33	in	in	IN
cord-332422-s15o0hie	306	34	the	the	DT
cord-332422-s15o0hie	306	35	presence	presence	NN
cord-332422-s15o0hie	306	36	of	of	IN
cord-332422-s15o0hie	306	37	neutralizing	neutralize	VBG
cord-332422-s15o0hie	306	38	antibodies	antibody	NNS
cord-332422-s15o0hie	306	39	CD81	CD81	NNP
cord-332422-s15o0hie	306	40	is	be	VBZ
cord-332422-s15o0hie	306	41	dispensable	dispensable	JJ
cord-332422-s15o0hie	306	42	for	for	IN
cord-332422-s15o0hie	306	43	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	44	C	C	NNP
cord-332422-s15o0hie	306	45	virus	virus	NN
cord-332422-s15o0hie	306	46	cell	cell	NN
cord-332422-s15o0hie	306	47	-	-	HYPH
cord-332422-s15o0hie	306	48	to	to	IN
cord-332422-s15o0hie	306	49	-	-	HYPH
cord-332422-s15o0hie	306	50	cell	cell	NN
cord-332422-s15o0hie	306	51	transmission	transmission	NN
cord-332422-s15o0hie	306	52	in	in	IN
cord-332422-s15o0hie	306	53	hepatoma	hepatoma	NNP
cord-332422-s15o0hie	306	54	cells	cell	VBZ
cord-332422-s15o0hie	306	55	Real	real	JJ
cord-332422-s15o0hie	306	56	-	-	HYPH
cord-332422-s15o0hie	306	57	time	time	NN
cord-332422-s15o0hie	306	58	imaging	imaging	NN
cord-332422-s15o0hie	306	59	of	of	IN
cord-332422-s15o0hie	306	60	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	61	C	C	NNP
cord-332422-s15o0hie	306	62	virus	virus	NN
cord-332422-s15o0hie	306	63	infection	infection	NN
cord-332422-s15o0hie	306	64	using	use	VBG
cord-332422-s15o0hie	306	65	a	a	DT
cord-332422-s15o0hie	306	66	fluorescent	fluorescent	JJ
cord-332422-s15o0hie	306	67	cell	cell	NN
cord-332422-s15o0hie	306	68	-	-	HYPH
cord-332422-s15o0hie	306	69	based	base	VBN
cord-332422-s15o0hie	306	70	reporter	reporter	NN
cord-332422-s15o0hie	306	71	system	system	NN
cord-332422-s15o0hie	306	72	Neutralizing	neutralize	VBG
cord-332422-s15o0hie	306	73	antibody	antibody	NN
cord-332422-s15o0hie	306	74	-	-	HYPH
cord-332422-s15o0hie	306	75	resistant	resistant	JJ
cord-332422-s15o0hie	306	76	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	77	C	c	NN
cord-332422-s15o0hie	306	78	virus	virus	NN
cord-332422-s15o0hie	306	79	cell	cell	NN
cord-332422-s15o0hie	306	80	-	-	HYPH
cord-332422-s15o0hie	306	81	to	to	IN
cord-332422-s15o0hie	306	82	-	-	HYPH
cord-332422-s15o0hie	306	83	cell	cell	NN
cord-332422-s15o0hie	306	84	transmission	transmission	NN
cord-332422-s15o0hie	306	85	Anti	Anti	NNP
cord-332422-s15o0hie	306	86	-	-	NNP
cord-332422-s15o0hie	306	87	CD81	CD81	NNP
cord-332422-s15o0hie	306	88	antibodies	antibody	NNS
cord-332422-s15o0hie	306	89	can	can	MD
cord-332422-s15o0hie	306	90	prevent	prevent	VB
cord-332422-s15o0hie	306	91	a	a	DT
cord-332422-s15o0hie	306	92	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	93	C	c	NN
cord-332422-s15o0hie	306	94	virus	virus	NN
cord-332422-s15o0hie	306	95	infection	infection	NN
cord-332422-s15o0hie	306	96	in	in	IN
cord-332422-s15o0hie	306	97	vivo	vivo	NNP
cord-332422-s15o0hie	306	98	Advantages	advantage	NNS
cord-332422-s15o0hie	306	99	of	of	IN
cord-332422-s15o0hie	306	100	a	a	DT
cord-332422-s15o0hie	306	101	single	single	JJ
cord-332422-s15o0hie	306	102	-	-	HYPH
cord-332422-s15o0hie	306	103	cycle	cycle	NN
cord-332422-s15o0hie	306	104	production	production	NN
cord-332422-s15o0hie	306	105	assay	assay	NN
cord-332422-s15o0hie	306	106	to	to	TO
cord-332422-s15o0hie	306	107	study	study	VB
cord-332422-s15o0hie	306	108	cell	cell	NN
cord-332422-s15o0hie	306	109	cultureadaptive	cultureadaptive	JJ
cord-332422-s15o0hie	306	110	mutations	mutation	NNS
cord-332422-s15o0hie	306	111	of	of	IN
cord-332422-s15o0hie	306	112	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	113	C	C	NNP
cord-332422-s15o0hie	306	114	virus	virus	NN
cord-332422-s15o0hie	306	115	Low	Low	NNP
cord-332422-s15o0hie	306	116	pHdependent	pHdependent	NNP
cord-332422-s15o0hie	306	117	hepatitis	hepatitis	NN
cord-332422-s15o0hie	306	118	C	c	NN
cord-332422-s15o0hie	306	119	virus	virus	NN
cord-332422-s15o0hie	306	120	membrane	membrane	NN
cord-332422-s15o0hie	306	121	fusion	fusion	NN
cord-332422-s15o0hie	306	122	depends	depend	VBZ
cord-332422-s15o0hie	306	123	on	on	IN
cord-332422-s15o0hie	306	124	E2	E2	NNP
cord-332422-s15o0hie	306	125	integrity	integrity	NN
cord-332422-s15o0hie	306	126	,	,	,
cord-332422-s15o0hie	306	127	target	target	VB
cord-332422-s15o0hie	306	128	lipid	lipid	NN
cord-332422-s15o0hie	306	129	composition	composition	NN
cord-332422-s15o0hie	306	130	,	,	,
cord-332422-s15o0hie	306	131	and	and	CC
cord-332422-s15o0hie	306	132	density	density	NN
cord-332422-s15o0hie	306	133	of	of	IN
cord-332422-s15o0hie	306	134	virus	virus	NN
cord-332422-s15o0hie	306	135	particles	particle	NNS
cord-332422-s15o0hie	306	136	Sindbis	Sindbis	NNP
cord-332422-s15o0hie	306	137	virus	virus	NN
cord-332422-s15o0hie	306	138	membrane	membrane	NN
cord-332422-s15o0hie	306	139	fusion	fusion	NN
cord-332422-s15o0hie	306	140	is	be	VBZ
cord-332422-s15o0hie	306	141	mediated	mediate	VBN
cord-332422-s15o0hie	306	142	by	by	IN
cord-332422-s15o0hie	306	143	reduction	reduction	NN
cord-332422-s15o0hie	306	144	of	of	IN
cord-332422-s15o0hie	306	145	glycoprotein	glycoprotein	NN
cord-332422-s15o0hie	306	146	disulfide	disulfide	NN
cord-332422-s15o0hie	306	147	bridges	bridge	NNS
cord-332422-s15o0hie	306	148	at	at	IN
cord-332422-s15o0hie	306	149	the	the	DT
cord-332422-s15o0hie	306	150	cell	cell	NN
cord-332422-s15o0hie	306	151	surface	surface	NN
cord-332422-s15o0hie	306	152	Cell	cell	NN
cord-332422-s15o0hie	306	153	entry	entry	NN
cord-332422-s15o0hie	306	154	by	by	IN
cord-332422-s15o0hie	306	155	enveloped	envelop	VBN
cord-332422-s15o0hie	306	156	viruses	virus	NNS
cord-332422-s15o0hie	306	157	:	:	:
cord-332422-s15o0hie	306	158	redox	redox	JJ
cord-332422-s15o0hie	306	159	considerations	consideration	NNS
cord-332422-s15o0hie	306	160	for	for	IN
cord-332422-s15o0hie	306	161	HIV	HIV	NNP
cord-332422-s15o0hie	306	162	and	and	CC
cord-332422-s15o0hie	306	163	SARS	SARS	NNP
cord-332422-s15o0hie	306	164	-	-	HYPH
cord-332422-s15o0hie	306	165	coronavirus	coronavirus	NN
cord-332422-s15o0hie	307	1	We	-PRON-	PRP
cord-332422-s15o0hie	307	2	apologize	apologize	VBP
cord-332422-s15o0hie	307	3	to	to	IN
cord-332422-s15o0hie	307	4	all	all	DT
cord-332422-s15o0hie	307	5	authors	author	NNS
cord-332422-s15o0hie	307	6	whose	whose	WP$
cord-332422-s15o0hie	307	7	work	work	NN
cord-332422-s15o0hie	307	8	could	could	MD
cord-332422-s15o0hie	307	9	not	not	RB
cord-332422-s15o0hie	307	10	be	be	VB
cord-332422-s15o0hie	307	11	cited	cite	VBN
cord-332422-s15o0hie	307	12	due	due	IN
cord-332422-s15o0hie	307	13	to	to	IN
cord-332422-s15o0hie	307	14	space	space	NN
cord-332422-s15o0hie	307	15	restrictions	restriction	NNS
cord-332422-s15o0hie	307	16	.	.	.
cord-332422-s15o0hie	308	1	We	-PRON-	PRP
cord-332422-s15o0hie	308	2	thank	thank	VBP
cord-332422-s15o0hie	308	3	Sophana	Sophana	NNP
cord-332422-s15o0hie	308	4	Ung	Ung	NNP
cord-332422-s15o0hie	308	5	 	 	_SP