id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253501-hkxlq3os	Anang, Saumya	Recent Advances Towards the Development of a Potent Antiviral Against the Hepatitis E Virus	2018-06-28		.txt	text/plain	4416	290	38	[29] [30] [31] [32] Ribavirin inhibits host inosine monophosphate dehydrogenase, thereby depleting cellular GTP pools and blocking viral replication during HEV infection. Sofosbuvir, a prodrug of a uridine nucleoside analogue that acts as a direct-acting antiviral against hepatitis C virus (HCV) RNA-dependent RNA polymerase in its active form, was reported by Dao Thi et al. 63, 64 Zinc salts were shown to block the replication of both genotype 1 and genotype 3 HEV by inhibiting the activity of viral RNA-dependent RNA polymerase in cultured human hepatoma cells. Zinc directly inhibits HEV RNA-dependent RNA polymerase activity in vitro and displays moderate cooperativity with ribavirin in inhibiting viral replication in mammalian cell culture models of HEV infection. Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection Zinc salts block hepatitis E virus replication by inhibiting the activity of viral RNA-dependent RNA polymerase	./cache/cord-253501-hkxlq3os.txt	./txt/cord-253501-hkxlq3os.txt