id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329137-5pw07qje	Dryden, Kelly A.	Immature and Mature Human Astrovirus: Structure, Conformational Changes, and Similarities to Hepatitis E Virus	2012-10-05		.txt	text/plain	3846	210	53	In addition, immature HAstV bears a striking resemblance to the structure of hepatitis E virus (HEV)-like particles, as previously predicted from structural similarity of the crystal structure of the astrovirus spike domain with the HEV P-domain [Dong, J., Dong, L., Méndez, E. Similarities between their capsid shells and dimeric spikes and between the sequences of their capsid proteins suggest that these viral families are phylogenetically related and may share common assembly and activation mechanisms. Immature, uncleaved particles, which are strikingly similar in appearance to HEV-like particles (HEV-lp), 14 Trypsin cleavage of the coat protein between the conserved (white boxes) and variable (shaded boxes) domains is required for viral maturation. If the cleaved proteins remain noncovalently associated with the capsid shell, then one would still expect to see surface density in the images of individual particles, even if the polypeptides do not conform to icosahedral symmetry.	./cache/cord-329137-5pw07qje.txt	./txt/cord-329137-5pw07qje.txt