id	sid	tid	token	lemma	pos
cord-253501-hkxlq3os	1	1	key	key	NN
cord-253501-hkxlq3os	1	2	:	:	:
cord-253501-hkxlq3os	1	3	cord-253501-hkxlq3os	cord-253501-hkxlq3os	.
cord-253501-hkxlq3os	1	4	authors	author	NNS
cord-253501-hkxlq3os	1	5	:	:	:
cord-253501-hkxlq3os	1	6	Anang	Anang	NNP
cord-253501-hkxlq3os	1	7	,	,	,
cord-253501-hkxlq3os	1	8	Saumya	Saumya	NNP
cord-253501-hkxlq3os	1	9	;	;	:
cord-253501-hkxlq3os	1	10	Kaushik	Kaushik	NNP
cord-253501-hkxlq3os	1	11	,	,	,
cord-253501-hkxlq3os	1	12	Nidhi	Nidhi	NNP
cord-253501-hkxlq3os	1	13	;	;	:
cord-253501-hkxlq3os	1	14	Surjit	Surjit	NNP
cord-253501-hkxlq3os	1	15	,	,	,
cord-253501-hkxlq3os	1	16	Milan	Milan	NNP
cord-253501-hkxlq3os	2	1	title	title	NN
cord-253501-hkxlq3os	2	2	:	:	:
cord-253501-hkxlq3os	3	1	Recent	recent	JJ
cord-253501-hkxlq3os	3	2	Advances	advance	NNS
cord-253501-hkxlq3os	3	3	Towards	towards	IN
cord-253501-hkxlq3os	3	4	the	the	DT
cord-253501-hkxlq3os	3	5	Development	Development	NNP
cord-253501-hkxlq3os	3	6	of	of	IN
cord-253501-hkxlq3os	3	7	a	a	DT
cord-253501-hkxlq3os	3	8	Potent	Potent	NNP
cord-253501-hkxlq3os	3	9	Antiviral	Antiviral	NNP
cord-253501-hkxlq3os	3	10	Against	against	IN
cord-253501-hkxlq3os	3	11	the	the	DT
cord-253501-hkxlq3os	3	12	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	3	13	E	E	NNP
cord-253501-hkxlq3os	3	14	Virus	Virus	NNP
cord-253501-hkxlq3os	3	15	date	date	NN
cord-253501-hkxlq3os	3	16	:	:	:
cord-253501-hkxlq3os	3	17	2018	2018	CD
cord-253501-hkxlq3os	3	18	-	-	HYPH
cord-253501-hkxlq3os	3	19	06	06	CD
cord-253501-hkxlq3os	3	20	-	-	HYPH
cord-253501-hkxlq3os	3	21	28	28	CD
cord-253501-hkxlq3os	3	22	journal	journal	NN
cord-253501-hkxlq3os	3	23	:	:	:
cord-253501-hkxlq3os	3	24	J	J	NNP
cord-253501-hkxlq3os	3	25	Clin	Clin	NNP
cord-253501-hkxlq3os	3	26	Transl	Transl	NNP
cord-253501-hkxlq3os	4	1	Hepatol	Hepatol	NNP
cord-253501-hkxlq3os	4	2	DOI	DOI	NNP
cord-253501-hkxlq3os	4	3	:	:	:
cord-253501-hkxlq3os	5	1	10.14218	10.14218	CD
cord-253501-hkxlq3os	5	2	/	/	SYM
cord-253501-hkxlq3os	5	3	jcth.2018.00005	jcth.2018.00005	XX
cord-253501-hkxlq3os	6	1	sha	sha	NNP
cord-253501-hkxlq3os	6	2	:	:	:
cord-253501-hkxlq3os	7	1	f98ea77d586b02146fe03a209e44a0c1e8883ea5	f98ea77d586b02146fe03a209e44a0c1e8883ea5	NNP
cord-253501-hkxlq3os	7	2	doc_id	doc_id	NNP
cord-253501-hkxlq3os	7	3	:	:	:
cord-253501-hkxlq3os	7	4	253501	253501	CD
cord-253501-hkxlq3os	7	5	cord_uid	cord_uid	NNS
cord-253501-hkxlq3os	7	6	:	:	:
cord-253501-hkxlq3os	8	1	hkxlq3os	hkxlq3os	NNP
cord-253501-hkxlq3os	8	2	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	8	3	E	E	NNP
cord-253501-hkxlq3os	8	4	virus	virus	NN
cord-253501-hkxlq3os	8	5	(	(	-LRB-
cord-253501-hkxlq3os	8	6	HEV	HEV	NNP
cord-253501-hkxlq3os	8	7	)	)	-RRB-
cord-253501-hkxlq3os	8	8	is	be	VBZ
cord-253501-hkxlq3os	8	9	one	one	CD
cord-253501-hkxlq3os	8	10	of	of	IN
cord-253501-hkxlq3os	8	11	the	the	DT
cord-253501-hkxlq3os	8	12	leading	lead	VBG
cord-253501-hkxlq3os	8	13	causes	cause	NNS
cord-253501-hkxlq3os	8	14	of	of	IN
cord-253501-hkxlq3os	8	15	acute	acute	JJ
cord-253501-hkxlq3os	8	16	viral	viral	JJ
cord-253501-hkxlq3os	8	17	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	8	18	.	.	.
cord-253501-hkxlq3os	9	1	It	-PRON-	PRP
cord-253501-hkxlq3os	9	2	also	also	RB
cord-253501-hkxlq3os	9	3	causes	cause	VBZ
cord-253501-hkxlq3os	9	4	acute	acute	JJ
cord-253501-hkxlq3os	9	5	liver	liver	NN
cord-253501-hkxlq3os	9	6	failure	failure	NN
cord-253501-hkxlq3os	9	7	and	and	CC
cord-253501-hkxlq3os	9	8	acute	acute	JJ
cord-253501-hkxlq3os	9	9	-	-	HYPH
cord-253501-hkxlq3os	9	10	on	on	IN
cord-253501-hkxlq3os	9	11	-	-	HYPH
cord-253501-hkxlq3os	9	12	chronic	chronic	JJ
cord-253501-hkxlq3os	9	13	liver	liver	NN
cord-253501-hkxlq3os	9	14	failure	failure	NN
cord-253501-hkxlq3os	9	15	in	in	IN
cord-253501-hkxlq3os	9	16	many	many	JJ
cord-253501-hkxlq3os	9	17	patients	patient	NNS
cord-253501-hkxlq3os	9	18	,	,	,
cord-253501-hkxlq3os	9	19	such	such	JJ
cord-253501-hkxlq3os	9	20	as	as	IN
cord-253501-hkxlq3os	9	21	those	those	DT
cord-253501-hkxlq3os	9	22	suffering	suffer	VBG
cord-253501-hkxlq3os	9	23	from	from	IN
cord-253501-hkxlq3os	9	24	other	other	JJ
cord-253501-hkxlq3os	9	25	infections	infection	NNS
cord-253501-hkxlq3os	9	26	/	/	SYM
cord-253501-hkxlq3os	9	27	liver	liver	NN
cord-253501-hkxlq3os	9	28	injuries	injury	NNS
cord-253501-hkxlq3os	9	29	or	or	CC
cord-253501-hkxlq3os	9	30	organ	organ	NN
cord-253501-hkxlq3os	9	31	transplant	transplant	NN
cord-253501-hkxlq3os	9	32	/	/	SYM
cord-253501-hkxlq3os	9	33	chemotherapy	chemotherapy	NN
cord-253501-hkxlq3os	9	34	recipients	recipient	NNS
cord-253501-hkxlq3os	9	35	.	.	.
cord-253501-hkxlq3os	10	1	Despite	despite	IN
cord-253501-hkxlq3os	10	2	widespread	widespread	JJ
cord-253501-hkxlq3os	10	3	sporadic	sporadic	JJ
cord-253501-hkxlq3os	10	4	and	and	CC
cord-253501-hkxlq3os	10	5	epidemic	epidemic	JJ
cord-253501-hkxlq3os	10	6	incidents	incident	NNS
cord-253501-hkxlq3os	10	7	,	,	,
cord-253501-hkxlq3os	10	8	there	there	EX
cord-253501-hkxlq3os	10	9	is	be	VBZ
cord-253501-hkxlq3os	10	10	no	no	DT
cord-253501-hkxlq3os	10	11	specific	specific	JJ
cord-253501-hkxlq3os	10	12	treatment	treatment	NN
cord-253501-hkxlq3os	10	13	against	against	IN
cord-253501-hkxlq3os	10	14	HEV	HEV	NNP
cord-253501-hkxlq3os	10	15	,	,	,
cord-253501-hkxlq3os	10	16	justifying	justify	VBG
cord-253501-hkxlq3os	10	17	an	an	DT
cord-253501-hkxlq3os	10	18	urgent	urgent	JJ
cord-253501-hkxlq3os	10	19	need	need	NN
cord-253501-hkxlq3os	10	20	for	for	IN
cord-253501-hkxlq3os	10	21	developing	develop	VBG
cord-253501-hkxlq3os	10	22	a	a	DT
cord-253501-hkxlq3os	10	23	potent	potent	JJ
cord-253501-hkxlq3os	10	24	antiviral	antiviral	JJ
cord-253501-hkxlq3os	10	25	against	against	IN
cord-253501-hkxlq3os	10	26	it	-PRON-	PRP
cord-253501-hkxlq3os	10	27	.	.	.
cord-253501-hkxlq3os	11	1	This	this	DT
cord-253501-hkxlq3os	11	2	review	review	NN
cord-253501-hkxlq3os	11	3	summarizes	summarize	VBZ
cord-253501-hkxlq3os	11	4	the	the	DT
cord-253501-hkxlq3os	11	5	known	known	JJ
cord-253501-hkxlq3os	11	6	antiviral	antiviral	JJ
cord-253501-hkxlq3os	11	7	candidates	candidate	NNS
cord-253501-hkxlq3os	11	8	and	and	CC
cord-253501-hkxlq3os	11	9	provides	provide	VBZ
cord-253501-hkxlq3os	11	10	an	an	DT
cord-253501-hkxlq3os	11	11	overview	overview	NN
cord-253501-hkxlq3os	11	12	of	of	IN
cord-253501-hkxlq3os	11	13	the	the	DT
cord-253501-hkxlq3os	11	14	potential	potential	JJ
cord-253501-hkxlq3os	11	15	targets	target	NNS
cord-253501-hkxlq3os	11	16	for	for	IN
cord-253501-hkxlq3os	11	17	the	the	DT
cord-253501-hkxlq3os	11	18	development	development	NN
cord-253501-hkxlq3os	11	19	of	of	IN
cord-253501-hkxlq3os	11	20	specific	specific	JJ
cord-253501-hkxlq3os	11	21	antivirals	antiviral	NNS
cord-253501-hkxlq3os	11	22	against	against	IN
cord-253501-hkxlq3os	11	23	HEV	HEV	NNP
cord-253501-hkxlq3os	11	24	.	.	.
cord-253501-hkxlq3os	12	1	Hepatitis	hepatitis	NN
cord-253501-hkxlq3os	12	2	E	e	NN
cord-253501-hkxlq3os	12	3	virus	virus	NN
cord-253501-hkxlq3os	12	4	(	(	-LRB-
cord-253501-hkxlq3os	12	5	HEV	HEV	NNP
cord-253501-hkxlq3os	12	6	)	)	-RRB-
cord-253501-hkxlq3os	12	7	is	be	VBZ
cord-253501-hkxlq3os	12	8	a	a	DT
cord-253501-hkxlq3os	12	9	positive	positive	JJ
cord-253501-hkxlq3os	12	10	-	-	HYPH
cord-253501-hkxlq3os	12	11	sense	sense	NN
cord-253501-hkxlq3os	12	12	,	,	,
cord-253501-hkxlq3os	12	13	single	single	JJ
cord-253501-hkxlq3os	12	14	-	-	HYPH
cord-253501-hkxlq3os	12	15	strand	strand	NN
cord-253501-hkxlq3os	12	16	RNA	RNA	NNP
cord-253501-hkxlq3os	12	17	virus	virus	NN
cord-253501-hkxlq3os	12	18	that	that	WDT
cord-253501-hkxlq3os	12	19	causes	cause	VBZ
cord-253501-hkxlq3os	12	20	acute	acute	JJ
cord-253501-hkxlq3os	12	21	and	and	CC
cord-253501-hkxlq3os	12	22	chronic	chronic	JJ
cord-253501-hkxlq3os	12	23	viral	viral	JJ
cord-253501-hkxlq3os	12	24	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	12	25	,	,	,
cord-253501-hkxlq3os	12	26	fulminant	fulminant	JJ
cord-253501-hkxlq3os	12	27	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	12	28	,	,	,
cord-253501-hkxlq3os	12	29	acute	acute	JJ
cord-253501-hkxlq3os	12	30	liver	liver	NN
cord-253501-hkxlq3os	12	31	failure	failure	NN
cord-253501-hkxlq3os	12	32	and	and	CC
cord-253501-hkxlq3os	12	33	acute	acute	JJ
cord-253501-hkxlq3os	12	34	-	-	HYPH
cord-253501-hkxlq3os	12	35	on	on	IN
cord-253501-hkxlq3os	12	36	-	-	HYPH
cord-253501-hkxlq3os	12	37	chronic	chronic	JJ
cord-253501-hkxlq3os	12	38	liver	liver	NN
cord-253501-hkxlq3os	12	39	failure	failure	NN
cord-253501-hkxlq3os	12	40	in	in	IN
cord-253501-hkxlq3os	12	41	infected	infected	JJ
cord-253501-hkxlq3os	12	42	individuals	individual	NNS
cord-253501-hkxlq3os	12	43	.	.	.
cord-253501-hkxlq3os	13	1	1	1	LS
cord-253501-hkxlq3os	14	1	It	-PRON-	PRP
cord-253501-hkxlq3os	14	2	is	be	VBZ
cord-253501-hkxlq3os	14	3	known	know	VBN
cord-253501-hkxlq3os	14	4	to	to	TO
cord-253501-hkxlq3os	14	5	be	be	VB
cord-253501-hkxlq3os	14	6	transmitted	transmit	VBN
cord-253501-hkxlq3os	14	7	through	through	IN
cord-253501-hkxlq3os	14	8	the	the	DT
cord-253501-hkxlq3os	14	9	fecal	fecal	JJ
cord-253501-hkxlq3os	14	10	-	-	HYPH
cord-253501-hkxlq3os	14	11	oral	oral	JJ
cord-253501-hkxlq3os	14	12	route	route	NN
cord-253501-hkxlq3os	14	13	,	,	,
cord-253501-hkxlq3os	14	14	transfusion	transfusion	NN
cord-253501-hkxlq3os	14	15	of	of	IN
cord-253501-hkxlq3os	14	16	infected	infected	JJ
cord-253501-hkxlq3os	14	17	blood	blood	NN
cord-253501-hkxlq3os	14	18	products	product	NNS
cord-253501-hkxlq3os	14	19	or	or	CC
cord-253501-hkxlq3os	14	20	through	through	IN
cord-253501-hkxlq3os	14	21	the	the	DT
cord-253501-hkxlq3os	14	22	vertical	vertical	JJ
cord-253501-hkxlq3os	14	23	route	route	NN
cord-253501-hkxlq3os	14	24	.	.	.
cord-253501-hkxlq3os	15	1	[	[	-LRB-
cord-253501-hkxlq3os	15	2	2	2	LS
cord-253501-hkxlq3os	15	3	]	]	-RRB-
cord-253501-hkxlq3os	15	4	[	[	-LRB-
cord-253501-hkxlq3os	15	5	3	3	CD
cord-253501-hkxlq3os	15	6	]	]	-RRB-
cord-253501-hkxlq3os	15	7	[	[	-LRB-
cord-253501-hkxlq3os	15	8	4	4	CD
cord-253501-hkxlq3os	15	9	]	]	-RRB-
cord-253501-hkxlq3os	15	10	[	[	-LRB-
cord-253501-hkxlq3os	15	11	5	5	CD
cord-253501-hkxlq3os	15	12	]	]	-RRB-
cord-253501-hkxlq3os	15	13	[	[	-LRB-
cord-253501-hkxlq3os	15	14	6	6	CD
cord-253501-hkxlq3os	15	15	]	]	-RRB-
cord-253501-hkxlq3os	15	16	[	[	-LRB-
cord-253501-hkxlq3os	15	17	7	7	CD
cord-253501-hkxlq3os	15	18	]	]	-RRB-
cord-253501-hkxlq3os	15	19	Zoonotic	zoonotic	JJ
cord-253501-hkxlq3os	15	20	transmission	transmission	NN
cord-253501-hkxlq3os	15	21	due	due	IN
cord-253501-hkxlq3os	15	22	to	to	IN
cord-253501-hkxlq3os	15	23	consumption	consumption	NN
cord-253501-hkxlq3os	15	24	of	of	IN
cord-253501-hkxlq3os	15	25	infected	infected	JJ
cord-253501-hkxlq3os	15	26	meat	meat	NN
cord-253501-hkxlq3os	15	27	products	product	NNS
cord-253501-hkxlq3os	15	28	,	,	,
cord-253501-hkxlq3os	15	29	resulting	result	VBG
cord-253501-hkxlq3os	15	30	in	in	IN
cord-253501-hkxlq3os	15	31	sporadic	sporadic	JJ
cord-253501-hkxlq3os	15	32	cases	case	NNS
cord-253501-hkxlq3os	15	33	,	,	,
cord-253501-hkxlq3os	15	34	is	be	VBZ
cord-253501-hkxlq3os	15	35	particularly	particularly	RB
cord-253501-hkxlq3os	15	36	frequent	frequent	JJ
cord-253501-hkxlq3os	15	37	in	in	IN
cord-253501-hkxlq3os	15	38	developed	develop	VBN
cord-253501-hkxlq3os	15	39	countries	country	NNS
cord-253501-hkxlq3os	15	40	.	.	.
cord-253501-hkxlq3os	16	1	8	8	CD
cord-253501-hkxlq3os	17	1	The	the	DT
cord-253501-hkxlq3os	17	2	disease	disease	NN
cord-253501-hkxlq3os	17	3	symptoms	symptom	NNS
cord-253501-hkxlq3os	17	4	include	include	VBP
cord-253501-hkxlq3os	17	5	jaundice	jaundice	NN
cord-253501-hkxlq3os	17	6	,	,	,
cord-253501-hkxlq3os	17	7	nausea	nausea	NN
cord-253501-hkxlq3os	17	8	,	,	,
cord-253501-hkxlq3os	17	9	vomiting	vomiting	NN
cord-253501-hkxlq3os	17	10	,	,	,
cord-253501-hkxlq3os	17	11	fever	fever	NN
cord-253501-hkxlq3os	17	12	and	and	CC
cord-253501-hkxlq3os	17	13	sore	sore	JJ
cord-253501-hkxlq3os	17	14	muscles	muscle	NNS
cord-253501-hkxlq3os	17	15	.	.	.
cord-253501-hkxlq3os	18	1	Though	though	IN
cord-253501-hkxlq3os	18	2	the	the	DT
cord-253501-hkxlq3os	18	3	infection	infection	NN
cord-253501-hkxlq3os	18	4	is	be	VBZ
cord-253501-hkxlq3os	18	5	acute	acute	JJ
cord-253501-hkxlq3os	18	6	in	in	IN
cord-253501-hkxlq3os	18	7	normal	normal	JJ
cord-253501-hkxlq3os	18	8	individuals	individual	NNS
cord-253501-hkxlq3os	18	9	,	,	,
cord-253501-hkxlq3os	18	10	it	-PRON-	PRP
cord-253501-hkxlq3os	18	11	becomes	become	VBZ
cord-253501-hkxlq3os	18	12	chronic	chronic	JJ
cord-253501-hkxlq3os	18	13	in	in	IN
cord-253501-hkxlq3os	18	14	immunocompromised	immunocompromised	JJ
cord-253501-hkxlq3os	18	15	patients	patient	NNS
cord-253501-hkxlq3os	18	16	,	,	,
cord-253501-hkxlq3os	18	17	such	such	JJ
cord-253501-hkxlq3os	18	18	as	as	IN
cord-253501-hkxlq3os	18	19	organ	organ	NN
cord-253501-hkxlq3os	18	20	transplant	transplant	NN
cord-253501-hkxlq3os	18	21	recipients	recipient	NNS
cord-253501-hkxlq3os	18	22	,	,	,
cord-253501-hkxlq3os	18	23	individuals	individual	NNS
cord-253501-hkxlq3os	18	24	infected	infect	VBN
cord-253501-hkxlq3os	18	25	with	with	IN
cord-253501-hkxlq3os	18	26	the	the	DT
cord-253501-hkxlq3os	18	27	human	human	JJ
cord-253501-hkxlq3os	18	28	immunodeficiency	immunodeficiency	NN
cord-253501-hkxlq3os	18	29	virus	virus	NN
cord-253501-hkxlq3os	18	30	,	,	,
cord-253501-hkxlq3os	18	31	and	and	CC
cord-253501-hkxlq3os	18	32	patients	patient	NNS
cord-253501-hkxlq3os	18	33	undergoing	undergo	VBG
cord-253501-hkxlq3os	18	34	chemotherapy	chemotherapy	NN
cord-253501-hkxlq3os	18	35	.	.	.
cord-253501-hkxlq3os	19	1	[	[	-LRB-
cord-253501-hkxlq3os	19	2	9	9	CD
cord-253501-hkxlq3os	19	3	]	]	-RRB-
cord-253501-hkxlq3os	19	4	[	[	-LRB-
cord-253501-hkxlq3os	19	5	10	10	CD
cord-253501-hkxlq3os	19	6	]	]	-RRB-
cord-253501-hkxlq3os	19	7	[	[	-LRB-
cord-253501-hkxlq3os	19	8	11	11	CD
cord-253501-hkxlq3os	19	9	]	]	-RRB-
cord-253501-hkxlq3os	19	10	[	[	-LRB-
cord-253501-hkxlq3os	19	11	12	12	CD
cord-253501-hkxlq3os	19	12	]	]	-RRB-
cord-253501-hkxlq3os	19	13	[	[	-LRB-
cord-253501-hkxlq3os	19	14	13	13	CD
cord-253501-hkxlq3os	19	15	]	]	-RRB-
cord-253501-hkxlq3os	20	1	[	[	-LRB-
cord-253501-hkxlq3os	20	2	14	14	CD
cord-253501-hkxlq3os	20	3	]	]	-RRB-
cord-253501-hkxlq3os	21	1	The	the	DT
cord-253501-hkxlq3os	21	2	disease	disease	NN
cord-253501-hkxlq3os	21	3	worsens	worsen	VBZ
cord-253501-hkxlq3os	21	4	in	in	IN
cord-253501-hkxlq3os	21	5	pregnancy	pregnancy	NN
cord-253501-hkxlq3os	21	6	,	,	,
cord-253501-hkxlq3os	21	7	with	with	IN
cord-253501-hkxlq3os	21	8	mortality	mortality	NN
cord-253501-hkxlq3os	21	9	rates	rate	NNS
cord-253501-hkxlq3os	21	10	reaching	reach	VBG
cord-253501-hkxlq3os	21	11	as	as	RB
cord-253501-hkxlq3os	21	12	high	high	JJ
cord-253501-hkxlq3os	21	13	as	as	IN
cord-253501-hkxlq3os	21	14	20	20	CD
cord-253501-hkxlq3os	21	15	to	to	TO
cord-253501-hkxlq3os	21	16	25	25	CD
cord-253501-hkxlq3os	21	17	%	%	NN
cord-253501-hkxlq3os	21	18	.	.	.
cord-253501-hkxlq3os	22	1	6	6	CD
cord-253501-hkxlq3os	22	2	,	,	,
cord-253501-hkxlq3os	22	3	15	15	CD
cord-253501-hkxlq3os	22	4	,	,	,
cord-253501-hkxlq3os	22	5	16	16	CD
cord-253501-hkxlq3os	22	6	Recent	recent	JJ
cord-253501-hkxlq3os	22	7	reports	report	NNS
cord-253501-hkxlq3os	22	8	have	have	VBP
cord-253501-hkxlq3os	22	9	described	describe	VBN
cord-253501-hkxlq3os	22	10	extra	extra	JJ
cord-253501-hkxlq3os	22	11	-	-	JJ
cord-253501-hkxlq3os	22	12	hepatic	hepatic	JJ
cord-253501-hkxlq3os	22	13	manifestations	manifestation	NNS
cord-253501-hkxlq3os	22	14	,	,	,
cord-253501-hkxlq3os	22	15	such	such	JJ
cord-253501-hkxlq3os	22	16	as	as	IN
cord-253501-hkxlq3os	22	17	Guillain	Guillain	NNP
cord-253501-hkxlq3os	22	18	-	-	HYPH
cord-253501-hkxlq3os	22	19	Barre	Barre	NNP
cord-253501-hkxlq3os	22	20	syndrome	syndrome	NN
cord-253501-hkxlq3os	22	21	,	,	,
cord-253501-hkxlq3os	22	22	neurological	neurological	JJ
cord-253501-hkxlq3os	22	23	amyotrophy	amyotrophy	NN
cord-253501-hkxlq3os	22	24	,	,	,
cord-253501-hkxlq3os	22	25	arthritis	arthritis	NN
cord-253501-hkxlq3os	22	26	,	,	,
cord-253501-hkxlq3os	22	27	pancreatitis	pancreatitis	NN
cord-253501-hkxlq3os	22	28	and	and	CC
cord-253501-hkxlq3os	22	29	glomerulonephritis	glomerulonephritis	NN
cord-253501-hkxlq3os	22	30	,	,	,
cord-253501-hkxlq3os	22	31	in	in	IN
cord-253501-hkxlq3os	22	32	several	several	JJ
cord-253501-hkxlq3os	22	33	HEV	HEV	NNP
cord-253501-hkxlq3os	22	34	infected	infect	VBN
cord-253501-hkxlq3os	22	35	patients	patient	NNS
cord-253501-hkxlq3os	22	36	.	.	.
cord-253501-hkxlq3os	23	1	[	[	-LRB-
cord-253501-hkxlq3os	23	2	17	17	CD
cord-253501-hkxlq3os	23	3	]	]	-RRB-
cord-253501-hkxlq3os	23	4	[	[	-LRB-
cord-253501-hkxlq3os	23	5	18	18	CD
cord-253501-hkxlq3os	23	6	]	]	-RRB-
cord-253501-hkxlq3os	23	7	[	[	-LRB-
cord-253501-hkxlq3os	23	8	19	19	CD
cord-253501-hkxlq3os	23	9	]	]	-RRB-
cord-253501-hkxlq3os	24	1	Drave	Drave	NNP
cord-253501-hkxlq3os	24	2	et	et	FW
cord-253501-hkxlq3os	24	3	al	al	NNP
cord-253501-hkxlq3os	24	4	.	.	.
cord-253501-hkxlq3os	25	1	20	20	CD
cord-253501-hkxlq3os	25	2	have	have	VBP
cord-253501-hkxlq3os	25	3	also	also	RB
cord-253501-hkxlq3os	25	4	demonstrated	demonstrate	VBN
cord-253501-hkxlq3os	25	5	the	the	DT
cord-253501-hkxlq3os	25	6	replication	replication	NN
cord-253501-hkxlq3os	25	7	of	of	IN
cord-253501-hkxlq3os	25	8	HEV	hev	NN
cord-253501-hkxlq3os	25	9	in	in	IN
cord-253501-hkxlq3os	25	10	human	human	JJ
cord-253501-hkxlq3os	25	11	neuronal	neuronal	JJ
cord-253501-hkxlq3os	25	12	-	-	HYPH
cord-253501-hkxlq3os	25	13	derived	derive	VBN
cord-253501-hkxlq3os	25	14	cell	cell	NN
cord-253501-hkxlq3os	25	15	lines	line	NNS
cord-253501-hkxlq3os	25	16	.	.	.
cord-253501-hkxlq3os	26	1	Out	out	IN
cord-253501-hkxlq3os	26	2	of	of	IN
cord-253501-hkxlq3os	26	3	the	the	DT
cord-253501-hkxlq3os	26	4	eight	eight	CD
cord-253501-hkxlq3os	26	5	recognized	recognize	VBN
cord-253501-hkxlq3os	26	6	genotypes	genotype	NNS
cord-253501-hkxlq3os	26	7	of	of	IN
cord-253501-hkxlq3os	26	8	HEV	hev	NN
cord-253501-hkxlq3os	26	9	,	,	,
cord-253501-hkxlq3os	26	10	genotypes	genotype	NNS
cord-253501-hkxlq3os	26	11	1	1	CD
cord-253501-hkxlq3os	26	12	and	and	CC
cord-253501-hkxlq3os	26	13	2	2	CD
cord-253501-hkxlq3os	26	14	were	be	VBD
cord-253501-hkxlq3os	26	15	responsible	responsible	JJ
cord-253501-hkxlq3os	26	16	for	for	IN
cord-253501-hkxlq3os	26	17	about	about	RB
cord-253501-hkxlq3os	26	18	20.1	20.1	CD
cord-253501-hkxlq3os	26	19	million	million	CD
cord-253501-hkxlq3os	26	20	infections	infection	NNS
cord-253501-hkxlq3os	26	21	in	in	IN
cord-253501-hkxlq3os	26	22	2005	2005	CD
cord-253501-hkxlq3os	26	23	,	,	,
cord-253501-hkxlq3os	26	24	including	include	VBG
cord-253501-hkxlq3os	26	25	3.4	3.4	CD
cord-253501-hkxlq3os	26	26	million	million	CD
cord-253501-hkxlq3os	26	27	symptomatic	symptomatic	JJ
cord-253501-hkxlq3os	26	28	cases	case	NNS
cord-253501-hkxlq3os	26	29	,	,	,
cord-253501-hkxlq3os	26	30	70,000	70,000	CD
cord-253501-hkxlq3os	26	31	fatalities	fatality	NNS
cord-253501-hkxlq3os	26	32	and	and	CC
cord-253501-hkxlq3os	26	33	30,000	30,000	CD
cord-253501-hkxlq3os	26	34	still	still	RB
cord-253501-hkxlq3os	26	35	births	birth	NNS
cord-253501-hkxlq3os	26	36	.	.	.
cord-253501-hkxlq3os	27	1	21	21	CD
cord-253501-hkxlq3os	27	2	Outbreaks	outbreak	NNS
cord-253501-hkxlq3os	27	3	of	of	IN
cord-253501-hkxlq3os	27	4	HEV	HEV	NNP
cord-253501-hkxlq3os	27	5	have	have	VBP
cord-253501-hkxlq3os	27	6	been	be	VBN
cord-253501-hkxlq3os	27	7	reported	report	VBN
cord-253501-hkxlq3os	27	8	from	from	IN
cord-253501-hkxlq3os	27	9	different	different	JJ
cord-253501-hkxlq3os	27	10	parts	part	NNS
cord-253501-hkxlq3os	27	11	of	of	IN
cord-253501-hkxlq3os	27	12	the	the	DT
cord-253501-hkxlq3os	27	13	world	world	NN
cord-253501-hkxlq3os	27	14	.	.	.
cord-253501-hkxlq3os	28	1	Several	several	JJ
cord-253501-hkxlq3os	28	2	parts	part	NNS
cord-253501-hkxlq3os	28	3	of	of	IN
cord-253501-hkxlq3os	28	4	eastern	eastern	NNP
cord-253501-hkxlq3os	28	5	and	and	CC
cord-253501-hkxlq3os	28	6	the	the	DT
cord-253501-hkxlq3os	28	7	central	central	JJ
cord-253501-hkxlq3os	28	8	India	India	NNP
cord-253501-hkxlq3os	28	9	,	,	,
cord-253501-hkxlq3os	28	10	including	include	VBG
cord-253501-hkxlq3os	28	11	Orissa	Orissa	NNP
cord-253501-hkxlq3os	28	12	,	,	,
cord-253501-hkxlq3os	28	13	Chhattisgarh	Chhattisgarh	NNP
cord-253501-hkxlq3os	28	14	,	,	,
cord-253501-hkxlq3os	28	15	Maharashtra	Maharashtra	NNP
cord-253501-hkxlq3os	28	16	and	and	CC
cord-253501-hkxlq3os	28	17	Nellore	Nellore	NNP
cord-253501-hkxlq3os	28	18	,	,	,
cord-253501-hkxlq3os	28	19	witnessed	witness	VBD
cord-253501-hkxlq3os	28	20	HEV	HEV	NNP
cord-253501-hkxlq3os	28	21	outbreaks	outbreak	NNS
cord-253501-hkxlq3os	28	22	between	between	IN
cord-253501-hkxlq3os	28	23	2008	2008	CD
cord-253501-hkxlq3os	28	24	-	-	SYM
cord-253501-hkxlq3os	28	25	2017	2017	CD
cord-253501-hkxlq3os	28	26	.	.	.
cord-253501-hkxlq3os	29	1	[	[	-LRB-
cord-253501-hkxlq3os	29	2	22	22	CD
cord-253501-hkxlq3os	29	3	]	]	-RRB-
cord-253501-hkxlq3os	29	4	[	[	-LRB-
cord-253501-hkxlq3os	29	5	23	23	CD
cord-253501-hkxlq3os	29	6	]	]	-RRB-
cord-253501-hkxlq3os	30	1	[	[	-LRB-
cord-253501-hkxlq3os	30	2	24	24	CD
cord-253501-hkxlq3os	30	3	]	]	-RRB-
cord-253501-hkxlq3os	30	4	[	[	-LRB-
cord-253501-hkxlq3os	30	5	25	25	CD
cord-253501-hkxlq3os	30	6	]	]	-RRB-
cord-253501-hkxlq3os	31	1	Many	many	JJ
cord-253501-hkxlq3os	31	2	parts	part	NNS
cord-253501-hkxlq3os	31	3	of	of	IN
cord-253501-hkxlq3os	31	4	Africa	Africa	NNP
cord-253501-hkxlq3os	31	5	have	have	VBP
cord-253501-hkxlq3os	31	6	also	also	RB
cord-253501-hkxlq3os	31	7	been	be	VBN
cord-253501-hkxlq3os	31	8	affected	affect	VBN
cord-253501-hkxlq3os	31	9	by	by	IN
cord-253501-hkxlq3os	31	10	frequent	frequent	JJ
cord-253501-hkxlq3os	31	11	HEV	HEV	NNP
cord-253501-hkxlq3os	31	12	epidemics	epidemic	NNS
cord-253501-hkxlq3os	31	13	.	.	.
cord-253501-hkxlq3os	32	1	Outbreaks	outbreak	NNS
cord-253501-hkxlq3os	32	2	were	be	VBD
cord-253501-hkxlq3os	32	3	also	also	RB
cord-253501-hkxlq3os	32	4	reported	report	VBN
cord-253501-hkxlq3os	32	5	from	from	IN
cord-253501-hkxlq3os	32	6	Egypt	Egypt	NNP
cord-253501-hkxlq3os	32	7	,	,	,
cord-253501-hkxlq3os	32	8	Uganda	Uganda	NNP
cord-253501-hkxlq3os	32	9	,	,	,
cord-253501-hkxlq3os	32	10	Sudan	Sudan	NNP
cord-253501-hkxlq3os	32	11	,	,	,
cord-253501-hkxlq3os	32	12	Ethiopia	Ethiopia	NNP
cord-253501-hkxlq3os	32	13	,	,	,
cord-253501-hkxlq3os	32	14	Chad	Chad	NNP
cord-253501-hkxlq3os	32	15	,	,	,
cord-253501-hkxlq3os	32	16	Niger	Niger	NNP
cord-253501-hkxlq3os	32	17	and	and	CC
cord-253501-hkxlq3os	32	18	Kenya	Kenya	NNP
cord-253501-hkxlq3os	32	19	.	.	.
cord-253501-hkxlq3os	33	1	26	26	CD
cord-253501-hkxlq3os	34	1	An	an	DT
cord-253501-hkxlq3os	34	2	outbreak	outbreak	NN
cord-253501-hkxlq3os	34	3	has	have	VBZ
cord-253501-hkxlq3os	34	4	even	even	RB
cord-253501-hkxlq3os	34	5	been	be	VBN
cord-253501-hkxlq3os	34	6	reported	report	VBN
cord-253501-hkxlq3os	34	7	from	from	IN
cord-253501-hkxlq3os	34	8	Australia	Australia	NNP
cord-253501-hkxlq3os	34	9	,	,	,
cord-253501-hkxlq3os	34	10	caused	cause	VBN
cord-253501-hkxlq3os	34	11	by	by	IN
cord-253501-hkxlq3os	34	12	a	a	DT
cord-253501-hkxlq3os	34	13	locally	locally	RB
cord-253501-hkxlq3os	34	14	-	-	HYPH
cord-253501-hkxlq3os	34	15	acquired	acquire	VBN
cord-253501-hkxlq3os	34	16	HEV	hev	NN
cord-253501-hkxlq3os	34	17	.	.	.
cord-253501-hkxlq3os	35	1	27	27	CD
cord-253501-hkxlq3os	36	1	The	the	DT
cord-253501-hkxlq3os	36	2	recent	recent	JJ
cord-253501-hkxlq3os	36	3	increase	increase	NN
cord-253501-hkxlq3os	36	4	in	in	IN
cord-253501-hkxlq3os	36	5	organ	organ	NN
cord-253501-hkxlq3os	36	6	transplantation	transplantation	NN
cord-253501-hkxlq3os	36	7	and	and	CC
cord-253501-hkxlq3os	36	8	exposure	exposure	NN
cord-253501-hkxlq3os	36	9	to	to	IN
cord-253501-hkxlq3os	36	10	the	the	DT
cord-253501-hkxlq3os	36	11	disease	disease	NN
cord-253501-hkxlq3os	36	12	due	due	JJ
cord-253501-hkxlq3os	36	13	to	to	IN
cord-253501-hkxlq3os	36	14	growing	grow	VBG
cord-253501-hkxlq3os	36	15	trade	trade	NN
cord-253501-hkxlq3os	36	16	and	and	CC
cord-253501-hkxlq3os	36	17	travel	travel	NN
cord-253501-hkxlq3os	36	18	has	have	VBZ
cord-253501-hkxlq3os	36	19	further	further	RB
cord-253501-hkxlq3os	36	20	expanded	expand	VBN
cord-253501-hkxlq3os	36	21	the	the	DT
cord-253501-hkxlq3os	36	22	incidence	incidence	NN
cord-253501-hkxlq3os	36	23	of	of	IN
cord-253501-hkxlq3os	36	24	HEV	HEV	NNP
cord-253501-hkxlq3os	36	25	infection	infection	NN
cord-253501-hkxlq3os	36	26	,	,	,
cord-253501-hkxlq3os	36	27	thereby	thereby	RB
cord-253501-hkxlq3os	36	28	intensifying	intensify	VBG
cord-253501-hkxlq3os	36	29	the	the	DT
cord-253501-hkxlq3os	36	30	need	need	NN
cord-253501-hkxlq3os	36	31	for	for	IN
cord-253501-hkxlq3os	36	32	research	research	NN
cord-253501-hkxlq3os	36	33	of	of	IN
cord-253501-hkxlq3os	36	34	antivirals	antiviral	NNS
cord-253501-hkxlq3os	36	35	against	against	IN
cord-253501-hkxlq3os	36	36	HEV	HEV	NNP
cord-253501-hkxlq3os	36	37	.	.	.
cord-253501-hkxlq3os	37	1	HEV	hev	VB
cord-253501-hkxlq3os	37	2	-	-	HYPH
cord-253501-hkxlq3os	37	3	induced	induce	VBN
cord-253501-hkxlq3os	37	4	acute	acute	JJ
cord-253501-hkxlq3os	37	5	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	37	6	is	be	VBZ
cord-253501-hkxlq3os	37	7	usually	usually	RB
cord-253501-hkxlq3os	37	8	self	self	NN
cord-253501-hkxlq3os	37	9	-	-	HYPH
cord-253501-hkxlq3os	37	10	limiting	limit	VBG
cord-253501-hkxlq3os	37	11	.	.	.
cord-253501-hkxlq3os	38	1	The	the	DT
cord-253501-hkxlq3os	38	2	disease	disease	NN
cord-253501-hkxlq3os	38	3	is	be	VBZ
cord-253501-hkxlq3os	38	4	generally	generally	RB
cord-253501-hkxlq3os	38	5	cured	cure	VBN
cord-253501-hkxlq3os	38	6	in	in	IN
cord-253501-hkxlq3os	38	7	4	4	CD
cord-253501-hkxlq3os	38	8	-	-	SYM
cord-253501-hkxlq3os	38	9	6	6	CD
cord-253501-hkxlq3os	38	10	weeks	week	NNS
cord-253501-hkxlq3os	38	11	,	,	,
cord-253501-hkxlq3os	38	12	without	without	IN
cord-253501-hkxlq3os	38	13	the	the	DT
cord-253501-hkxlq3os	38	14	need	need	NN
cord-253501-hkxlq3os	38	15	of	of	IN
cord-253501-hkxlq3os	38	16	any	any	DT
cord-253501-hkxlq3os	38	17	medication	medication	NN
cord-253501-hkxlq3os	38	18	.	.	.
cord-253501-hkxlq3os	39	1	During	during	IN
cord-253501-hkxlq3os	39	2	severe	severe	JJ
cord-253501-hkxlq3os	39	3	acute	acute	JJ
cord-253501-hkxlq3os	39	4	and	and	CC
cord-253501-hkxlq3os	39	5	chronic	chronic	JJ
cord-253501-hkxlq3os	39	6	infections	infection	NNS
cord-253501-hkxlq3os	39	7	,	,	,
cord-253501-hkxlq3os	39	8	a	a	DT
cord-253501-hkxlq3os	39	9	reduction	reduction	NN
cord-253501-hkxlq3os	39	10	in	in	IN
cord-253501-hkxlq3os	39	11	immunosuppressant	immunosuppressant	JJ
cord-253501-hkxlq3os	39	12	dose	dose	NN
cord-253501-hkxlq3os	39	13	or	or	CC
cord-253501-hkxlq3os	39	14	administration	administration	NN
cord-253501-hkxlq3os	39	15	of	of	IN
cord-253501-hkxlq3os	39	16	pegylated	pegylate	VBN
cord-253501-hkxlq3os	39	17	-	-	HYPH
cord-253501-hkxlq3os	39	18	interferon	interferon	NN
cord-253501-hkxlq3os	39	19	-	-	HYPH
cord-253501-hkxlq3os	39	20	alpha	alpha	NN
cord-253501-hkxlq3os	39	21	(	(	-LRB-
cord-253501-hkxlq3os	39	22	PEG	PEG	NNP
cord-253501-hkxlq3os	39	23	-	-	HYPH
cord-253501-hkxlq3os	39	24	IFN	IFN	NNP
cord-253501-hkxlq3os	39	25	-	-	HYPH
cord-253501-hkxlq3os	39	26	a	a	NN
cord-253501-hkxlq3os	39	27	)	)	-RRB-
cord-253501-hkxlq3os	39	28	,	,	,
cord-253501-hkxlq3os	39	29	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	39	30	or	or	CC
cord-253501-hkxlq3os	39	31	a	a	DT
cord-253501-hkxlq3os	39	32	combination	combination	NN
cord-253501-hkxlq3os	39	33	of	of	IN
cord-253501-hkxlq3os	39	34	both	both	DT
cord-253501-hkxlq3os	39	35	is	be	VBZ
cord-253501-hkxlq3os	39	36	the	the	DT
cord-253501-hkxlq3os	39	37	available	available	JJ
cord-253501-hkxlq3os	39	38	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	39	39	option	option	NN
cord-253501-hkxlq3os	39	40	.	.	.
cord-253501-hkxlq3os	40	1	Reduction	reduction	NN
cord-253501-hkxlq3os	40	2	in	in	IN
cord-253501-hkxlq3os	40	3	immunosuppressant	immunosuppressant	JJ
cord-253501-hkxlq3os	40	4	dose	dose	NN
cord-253501-hkxlq3os	40	5	helps	help	VBZ
cord-253501-hkxlq3os	40	6	in	in	IN
cord-253501-hkxlq3os	40	7	virus	virus	NN
cord-253501-hkxlq3os	40	8	clearance	clearance	NN
cord-253501-hkxlq3os	40	9	in	in	IN
cord-253501-hkxlq3os	40	10	approximately	approximately	RB
cord-253501-hkxlq3os	40	11	30	30	CD
cord-253501-hkxlq3os	40	12	%	%	NN
cord-253501-hkxlq3os	40	13	of	of	IN
cord-253501-hkxlq3os	40	14	organ	organ	NN
cord-253501-hkxlq3os	40	15	transplant	transplant	NN
cord-253501-hkxlq3os	40	16	patients	patient	NNS
cord-253501-hkxlq3os	40	17	.	.	.
cord-253501-hkxlq3os	41	1	28	28	CD
cord-253501-hkxlq3os	42	1	Ribavirin	ribavirin	RB
cord-253501-hkxlq3os	42	2	monotherapy	monotherapy	NN
cord-253501-hkxlq3os	42	3	has	have	VBZ
cord-253501-hkxlq3os	42	4	been	be	VBN
cord-253501-hkxlq3os	42	5	found	find	VBN
cord-253501-hkxlq3os	42	6	to	to	TO
cord-253501-hkxlq3os	42	7	be	be	VB
cord-253501-hkxlq3os	42	8	effective	effective	JJ
cord-253501-hkxlq3os	42	9	in	in	IN
cord-253501-hkxlq3os	42	10	the	the	DT
cord-253501-hkxlq3os	42	11	treatment	treatment	NN
cord-253501-hkxlq3os	42	12	of	of	IN
cord-253501-hkxlq3os	42	13	chronic	chronic	JJ
cord-253501-hkxlq3os	42	14	HEV	HEV	NNP
cord-253501-hkxlq3os	42	15	infection	infection	NN
cord-253501-hkxlq3os	42	16	.	.	.
cord-253501-hkxlq3os	43	1	[	[	-LRB-
cord-253501-hkxlq3os	43	2	29	29	CD
cord-253501-hkxlq3os	43	3	]	]	-RRB-
cord-253501-hkxlq3os	43	4	[	[	-LRB-
cord-253501-hkxlq3os	43	5	30	30	CD
cord-253501-hkxlq3os	43	6	]	]	-RRB-
cord-253501-hkxlq3os	43	7	[	[	-LRB-
cord-253501-hkxlq3os	43	8	31	31	CD
cord-253501-hkxlq3os	43	9	]	]	-RRB-
cord-253501-hkxlq3os	44	1	[	[	-LRB-
cord-253501-hkxlq3os	44	2	32	32	CD
cord-253501-hkxlq3os	44	3	]	]	-RRB-
cord-253501-hkxlq3os	45	1	Ribavirin	Ribavirin	NNP
cord-253501-hkxlq3os	45	2	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	45	3	host	host	NN
cord-253501-hkxlq3os	45	4	inosine	inosine	NN
cord-253501-hkxlq3os	45	5	monophosphate	monophosphate	NN
cord-253501-hkxlq3os	45	6	dehydrogenase	dehydrogenase	NN
cord-253501-hkxlq3os	45	7	,	,	,
cord-253501-hkxlq3os	45	8	thereby	thereby	RB
cord-253501-hkxlq3os	45	9	depleting	deplete	VBG
cord-253501-hkxlq3os	45	10	cellular	cellular	JJ
cord-253501-hkxlq3os	45	11	GTP	GTP	NNP
cord-253501-hkxlq3os	45	12	pools	pool	NNS
cord-253501-hkxlq3os	45	13	and	and	CC
cord-253501-hkxlq3os	45	14	blocking	block	VBG
cord-253501-hkxlq3os	45	15	viral	viral	JJ
cord-253501-hkxlq3os	45	16	replication	replication	NN
cord-253501-hkxlq3os	45	17	during	during	IN
cord-253501-hkxlq3os	45	18	HEV	HEV	NNP
cord-253501-hkxlq3os	45	19	infection	infection	NN
cord-253501-hkxlq3os	45	20	.	.	.
cord-253501-hkxlq3os	46	1	33	33	CD
cord-253501-hkxlq3os	47	1	Another	another	DT
cord-253501-hkxlq3os	47	2	possible	possible	JJ
cord-253501-hkxlq3os	47	3	mechanism	mechanism	NN
cord-253501-hkxlq3os	47	4	of	of	IN
cord-253501-hkxlq3os	47	5	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	47	6	action	action	NN
cord-253501-hkxlq3os	47	7	on	on	IN
cord-253501-hkxlq3os	47	8	HEV	HEV	NNP
cord-253501-hkxlq3os	47	9	is	be	VBZ
cord-253501-hkxlq3os	47	10	attributed	attribute	VBN
cord-253501-hkxlq3os	47	11	to	to	IN
cord-253501-hkxlq3os	47	12	its	-PRON-	PRP$
cord-253501-hkxlq3os	47	13	ability	ability	NN
cord-253501-hkxlq3os	47	14	to	to	TO
cord-253501-hkxlq3os	47	15	induce	induce	VB
cord-253501-hkxlq3os	47	16	mutations	mutation	NNS
cord-253501-hkxlq3os	47	17	in	in	IN
cord-253501-hkxlq3os	47	18	the	the	DT
cord-253501-hkxlq3os	47	19	viral	viral	JJ
cord-253501-hkxlq3os	47	20	genome	genome	NN
cord-253501-hkxlq3os	48	1	(	(	-LRB-
cord-253501-hkxlq3os	48	2	Fig	Fig	NNP
cord-253501-hkxlq3os	48	3	.	.	NNP
cord-253501-hkxlq3os	48	4	1	1	CD
cord-253501-hkxlq3os	48	5	)	)	-RRB-
cord-253501-hkxlq3os	48	6	.	.	.
cord-253501-hkxlq3os	49	1	The	the	DT
cord-253501-hkxlq3os	49	2	G1634R	G1634R	NNP
cord-253501-hkxlq3os	49	3	mutation	mutation	NN
cord-253501-hkxlq3os	49	4	in	in	IN
cord-253501-hkxlq3os	49	5	the	the	DT
cord-253501-hkxlq3os	49	6	HEV	hev	NN
cord-253501-hkxlq3os	49	7	polymerase	polymerase	NN
cord-253501-hkxlq3os	49	8	increases	increase	VBZ
cord-253501-hkxlq3os	49	9	the	the	DT
cord-253501-hkxlq3os	49	10	replication	replication	NN
cord-253501-hkxlq3os	49	11	competence	competence	NN
cord-253501-hkxlq3os	49	12	of	of	IN
cord-253501-hkxlq3os	49	13	the	the	DT
cord-253501-hkxlq3os	49	14	HEV	HEV	NNP
cord-253501-hkxlq3os	49	15	genome	genome	NN
cord-253501-hkxlq3os	49	16	and	and	CC
cord-253501-hkxlq3os	49	17	has	have	VBZ
cord-253501-hkxlq3os	49	18	been	be	VBN
cord-253501-hkxlq3os	49	19	shown	show	VBN
cord-253501-hkxlq3os	49	20	to	to	TO
cord-253501-hkxlq3os	49	21	confer	confer	VB
cord-253501-hkxlq3os	49	22	resistance	resistance	NN
cord-253501-hkxlq3os	49	23	against	against	IN
cord-253501-hkxlq3os	49	24	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	49	25	treatment	treatment	NN
cord-253501-hkxlq3os	49	26	in	in	IN
cord-253501-hkxlq3os	49	27	some	some	DT
cord-253501-hkxlq3os	49	28	patients	patient	NNS
cord-253501-hkxlq3os	49	29	.	.	.
cord-253501-hkxlq3os	50	1	However	however	RB
cord-253501-hkxlq3os	50	2	,	,	,
cord-253501-hkxlq3os	50	3	subsequent	subsequent	JJ
cord-253501-hkxlq3os	50	4	studies	study	NNS
cord-253501-hkxlq3os	50	5	revealed	reveal	VBD
cord-253501-hkxlq3os	50	6	that	that	IN
cord-253501-hkxlq3os	50	7	the	the	DT
cord-253501-hkxlq3os	50	8	G1634R	G1634R	NNP
cord-253501-hkxlq3os	50	9	mutation	mutation	NN
cord-253501-hkxlq3os	50	10	does	do	VBZ
cord-253501-hkxlq3os	50	11	not	not	RB
cord-253501-hkxlq3os	50	12	lead	lead	VB
cord-253501-hkxlq3os	50	13	to	to	IN
cord-253501-hkxlq3os	50	14	absolute	absolute	JJ
cord-253501-hkxlq3os	50	15	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	50	16	resistance	resistance	NN
cord-253501-hkxlq3os	50	17	.	.	.
cord-253501-hkxlq3os	51	1	[	[	-LRB-
cord-253501-hkxlq3os	51	2	34	34	CD
cord-253501-hkxlq3os	51	3	]	]	-RRB-
cord-253501-hkxlq3os	51	4	[	[	-LRB-
cord-253501-hkxlq3os	51	5	35	35	CD
cord-253501-hkxlq3os	51	6	]	]	-RRB-
cord-253501-hkxlq3os	51	7	[	[	-LRB-
cord-253501-hkxlq3os	51	8	36	36	CD
cord-253501-hkxlq3os	51	9	]	]	-RRB-
cord-253501-hkxlq3os	51	10	[	[	-LRB-
cord-253501-hkxlq3os	51	11	37	37	CD
cord-253501-hkxlq3os	51	12	]	]	-RRB-
cord-253501-hkxlq3os	52	1	A	a	DT
cord-253501-hkxlq3os	52	2	major	major	JJ
cord-253501-hkxlq3os	52	3	limitation	limitation	NN
cord-253501-hkxlq3os	52	4	of	of	IN
cord-253501-hkxlq3os	52	5	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	52	6	therapy	therapy	NN
cord-253501-hkxlq3os	52	7	is	be	VBZ
cord-253501-hkxlq3os	52	8	attributed	attribute	VBN
cord-253501-hkxlq3os	52	9	to	to	IN
cord-253501-hkxlq3os	52	10	the	the	DT
cord-253501-hkxlq3os	52	11	undesirable	undesirable	JJ
cord-253501-hkxlq3os	52	12	consequences	consequence	NNS
cord-253501-hkxlq3os	52	13	of	of	IN
cord-253501-hkxlq3os	52	14	the	the	DT
cord-253501-hkxlq3os	52	15	treatment	treatment	NN
cord-253501-hkxlq3os	52	16	,	,	,
cord-253501-hkxlq3os	52	17	such	such	JJ
cord-253501-hkxlq3os	52	18	as	as	IN
cord-253501-hkxlq3os	52	19	:	:	:
cord-253501-hkxlq3os	52	20	(	(	-LRB-
cord-253501-hkxlq3os	52	21	i	i	NN
cord-253501-hkxlq3os	52	22	)	)	-RRB-
cord-253501-hkxlq3os	53	1	it	-PRON-	PRP
cord-253501-hkxlq3os	53	2	's	be	VBZ
cord-253501-hkxlq3os	53	3	not	not	RB
cord-253501-hkxlq3os	53	4	being	be	VBG
cord-253501-hkxlq3os	53	5	a	a	DT
cord-253501-hkxlq3os	53	6	treatment	treatment	NN
cord-253501-hkxlq3os	53	7	option	option	NN
cord-253501-hkxlq3os	53	8	during	during	IN
cord-253501-hkxlq3os	53	9	pregnancy	pregnancy	NN
cord-253501-hkxlq3os	53	10	,	,	,
cord-253501-hkxlq3os	53	11	owing	owe	VBG
cord-253501-hkxlq3os	53	12	to	to	IN
cord-253501-hkxlq3os	53	13	its	-PRON-	PRP$
cord-253501-hkxlq3os	53	14	teratogenicity	teratogenicity	NN
cord-253501-hkxlq3os	53	15	;	;	:
cord-253501-hkxlq3os	53	16	(	(	-LRB-
cord-253501-hkxlq3os	53	17	ii	ii	NN
cord-253501-hkxlq3os	53	18	)	)	-RRB-
cord-253501-hkxlq3os	53	19	its	-PRON-	PRP$
cord-253501-hkxlq3os	53	20	potential	potential	NN
cord-253501-hkxlq3os	53	21	to	to	TO
cord-253501-hkxlq3os	53	22	cause	cause	VB
cord-253501-hkxlq3os	53	23	hemolytic	hemolytic	JJ
cord-253501-hkxlq3os	53	24	anemia	anemia	NN
cord-253501-hkxlq3os	53	25	and	and	CC
cord-253501-hkxlq3os	53	26	decreased	decrease	VBD
cord-253501-hkxlq3os	53	27	hemoglobin	hemoglobin	NN
cord-253501-hkxlq3os	53	28	,	,	,
cord-253501-hkxlq3os	53	29	requiring	require	VBG
cord-253501-hkxlq3os	53	30	direct	direct	JJ
cord-253501-hkxlq3os	53	31	supervision	supervision	NN
cord-253501-hkxlq3os	53	32	of	of	IN
cord-253501-hkxlq3os	53	33	hemolytic	hemolytic	JJ
cord-253501-hkxlq3os	53	34	parameters	parameter	NNS
cord-253501-hkxlq3os	53	35	during	during	IN
cord-253501-hkxlq3os	53	36	its	-PRON-	PRP$
cord-253501-hkxlq3os	53	37	application	application	NN
cord-253501-hkxlq3os	53	38	;	;	:
cord-253501-hkxlq3os	53	39	38	38	CD
cord-253501-hkxlq3os	53	40	and	and	CC
cord-253501-hkxlq3os	53	41	(	(	-LRB-
cord-253501-hkxlq3os	53	42	iii	iii	NN
cord-253501-hkxlq3os	53	43	)	)	-RRB-
cord-253501-hkxlq3os	53	44	its	-PRON-	PRP$
cord-253501-hkxlq3os	53	45	potential	potential	NN
cord-253501-hkxlq3os	53	46	to	to	TO
cord-253501-hkxlq3os	53	47	cause	cause	VB
cord-253501-hkxlq3os	53	48	insomnia	insomnia	NN
cord-253501-hkxlq3os	53	49	,	,	,
cord-253501-hkxlq3os	53	50	dyspnea	dyspnea	NN
cord-253501-hkxlq3os	53	51	,	,	,
cord-253501-hkxlq3os	53	52	lack	lack	NN
cord-253501-hkxlq3os	53	53	of	of	IN
cord-253501-hkxlq3os	53	54	concentration	concentration	NN
cord-253501-hkxlq3os	53	55	and	and	CC
cord-253501-hkxlq3os	53	56	irritability	irritability	NN
cord-253501-hkxlq3os	53	57	.	.	.
cord-253501-hkxlq3os	54	1	38	38	CD
cord-253501-hkxlq3os	54	2	HEV	HEV	NNP
cord-253501-hkxlq3os	54	3	enters	enter	VBZ
cord-253501-hkxlq3os	54	4	a	a	DT
cord-253501-hkxlq3os	54	5	permissive	permissive	JJ
cord-253501-hkxlq3os	54	6	cell	cell	NN
cord-253501-hkxlq3os	54	7	supposedly	supposedly	RB
cord-253501-hkxlq3os	54	8	through	through	IN
cord-253501-hkxlq3os	54	9	a	a	DT
cord-253501-hkxlq3os	54	10	receptor	receptor	NN
cord-253501-hkxlq3os	54	11	-	-	HYPH
cord-253501-hkxlq3os	54	12	dependent	dependent	JJ
cord-253501-hkxlq3os	54	13	process	process	NN
cord-253501-hkxlq3os	54	14	,	,	,
cord-253501-hkxlq3os	54	15	aided	aid	VBN
cord-253501-hkxlq3os	54	16	by	by	IN
cord-253501-hkxlq3os	54	17	heparan	heparan	JJ
cord-253501-hkxlq3os	54	18	sulfate	sulfate	NN
cord-253501-hkxlq3os	54	19	proteoglycans	proteoglycan	NNS
cord-253501-hkxlq3os	54	20	(	(	-LRB-
cord-253501-hkxlq3os	54	21	HSPGs	hspg	NNS
cord-253501-hkxlq3os	54	22	)	)	-RRB-
cord-253501-hkxlq3os	54	23	and	and	CC
cord-253501-hkxlq3os	54	24	other	other	JJ
cord-253501-hkxlq3os	54	25	unknown	unknown	JJ
cord-253501-hkxlq3os	54	26	factors	factor	NNS
cord-253501-hkxlq3os	54	27	.	.	.
cord-253501-hkxlq3os	55	1	The	the	DT
cord-253501-hkxlq3os	55	2	viral	viral	JJ
cord-253501-hkxlq3os	55	3	genome	genome	NN
cord-253501-hkxlq3os	55	4	is	be	VBZ
cord-253501-hkxlq3os	55	5	released	release	VBN
cord-253501-hkxlq3os	55	6	,	,	,
cord-253501-hkxlq3os	55	7	ORF1	ORF1	NNP
cord-253501-hkxlq3os	55	8	gets	get	VBZ
cord-253501-hkxlq3os	55	9	translated	translate	VBN
cord-253501-hkxlq3os	55	10	and	and	CC
cord-253501-hkxlq3os	55	11	processed	process	VBN
cord-253501-hkxlq3os	55	12	into	into	IN
cord-253501-hkxlq3os	55	13	different	different	JJ
cord-253501-hkxlq3os	55	14	functional	functional	JJ
cord-253501-hkxlq3os	55	15	domains	domain	NNS
cord-253501-hkxlq3os	55	16	,	,	,
cord-253501-hkxlq3os	55	17	followed	follow	VBN
cord-253501-hkxlq3os	55	18	by	by	IN
cord-253501-hkxlq3os	55	19	replication	replication	NN
cord-253501-hkxlq3os	55	20	.	.	.
cord-253501-hkxlq3os	56	1	Multiple	multiple	JJ
cord-253501-hkxlq3os	56	2	copies	copy	NNS
cord-253501-hkxlq3os	56	3	of	of	IN
cord-253501-hkxlq3os	56	4	capped	cap	VBN
cord-253501-hkxlq3os	56	5	(	(	-LRB-
cord-253501-hkxlq3os	56	6	green	green	JJ
cord-253501-hkxlq3os	56	7	box	box	NN
cord-253501-hkxlq3os	56	8	)	)	-RRB-
cord-253501-hkxlq3os	56	9	genomic	genomic	JJ
cord-253501-hkxlq3os	56	10	(	(	-LRB-
cord-253501-hkxlq3os	56	11	g)RNA	g)RNA	NNP
cord-253501-hkxlq3os	56	12	and	and	CC
cord-253501-hkxlq3os	56	13	subgenomic	subgenomic	NNP
cord-253501-hkxlq3os	56	14	(	(	-LRB-
cord-253501-hkxlq3os	56	15	sg)RNAs	sg)RNAs	NNP
cord-253501-hkxlq3os	56	16	are	be	VBP
cord-253501-hkxlq3os	56	17	thus	thus	RB
cord-253501-hkxlq3os	56	18	produced	produce	VBN
cord-253501-hkxlq3os	56	19	.	.	.
cord-253501-hkxlq3os	57	1	SgRNAs	sgrna	NNS
cord-253501-hkxlq3os	57	2	synthesize	synthesize	VBP
cord-253501-hkxlq3os	57	3	viral	viral	JJ
cord-253501-hkxlq3os	57	4	capsid	capsid	NN
cord-253501-hkxlq3os	57	5	(	(	-LRB-
cord-253501-hkxlq3os	57	6	ORF2	ORF2	NNP
cord-253501-hkxlq3os	57	7	)	)	-RRB-
cord-253501-hkxlq3os	57	8	and	and	CC
cord-253501-hkxlq3os	57	9	ORF3	ORF3	NNP
cord-253501-hkxlq3os	57	10	proteins	protein	NNS
cord-253501-hkxlq3os	57	11	.	.	.
cord-253501-hkxlq3os	58	1	ORF2	ORF2	NNP
cord-253501-hkxlq3os	58	2	,	,	,
cord-253501-hkxlq3os	58	3	gRNA	gRNA	NNS
cord-253501-hkxlq3os	58	4	and	and	CC
cord-253501-hkxlq3os	58	5	other	other	JJ
cord-253501-hkxlq3os	58	6	viral	viral	JJ
cord-253501-hkxlq3os	59	1	and/or	and/or	CC
cord-253501-hkxlq3os	60	1	host	host	NN
cord-253501-hkxlq3os	60	2	factors	factor	NNS
cord-253501-hkxlq3os	60	3	mediate	mediate	VBP
cord-253501-hkxlq3os	60	4	assembly	assembly	NN
cord-253501-hkxlq3os	60	5	of	of	IN
cord-253501-hkxlq3os	60	6	new	new	JJ
cord-253501-hkxlq3os	60	7	virions	virion	NNS
cord-253501-hkxlq3os	60	8	,	,	,
cord-253501-hkxlq3os	60	9	which	which	WDT
cord-253501-hkxlq3os	60	10	are	be	VBP
cord-253501-hkxlq3os	60	11	released	release	VBN
cord-253501-hkxlq3os	60	12	out	out	IN
cord-253501-hkxlq3os	60	13	of	of	IN
cord-253501-hkxlq3os	60	14	the	the	DT
cord-253501-hkxlq3os	60	15	cell	cell	NN
cord-253501-hkxlq3os	60	16	through	through	IN
cord-253501-hkxlq3os	60	17	an	an	DT
cord-253501-hkxlq3os	60	18	endosomal	endosomal	NNP
cord-253501-hkxlq3os	60	19	sorting	sort	VBG
cord-253501-hkxlq3os	60	20	complex	complex	NN
cord-253501-hkxlq3os	60	21	required	require	VBN
cord-253501-hkxlq3os	60	22	for	for	IN
cord-253501-hkxlq3os	60	23	transport	transport	NN
cord-253501-hkxlq3os	60	24	(	(	-LRB-
cord-253501-hkxlq3os	60	25	ESCRT)-dependent	ESCRT)-dependent	NNP
cord-253501-hkxlq3os	60	26	process	process	NN
cord-253501-hkxlq3os	60	27	involving	involve	VBG
cord-253501-hkxlq3os	60	28	the	the	DT
cord-253501-hkxlq3os	60	29	viral	viral	JJ
cord-253501-hkxlq3os	60	30	ORF3	ORF3	NNP
cord-253501-hkxlq3os	60	31	protein	protein	NN
cord-253501-hkxlq3os	60	32	.	.	.
cord-253501-hkxlq3os	61	1	The	the	DT
cord-253501-hkxlq3os	61	2	green	green	JJ
cord-253501-hkxlq3os	61	3	asterik	asterik	NN
cord-253501-hkxlq3os	61	4	indicates	indicate	VBZ
cord-253501-hkxlq3os	61	5	the	the	DT
cord-253501-hkxlq3os	61	6	steps	step	NNS
cord-253501-hkxlq3os	61	7	that	that	WDT
cord-253501-hkxlq3os	61	8	can	can	MD
cord-253501-hkxlq3os	61	9	be	be	VB
cord-253501-hkxlq3os	61	10	targeted	target	VBN
cord-253501-hkxlq3os	61	11	for	for	IN
cord-253501-hkxlq3os	61	12	antiviral	antiviral	JJ
cord-253501-hkxlq3os	61	13	development	development	NN
cord-253501-hkxlq3os	61	14	.	.	.
cord-253501-hkxlq3os	62	1	A	a	LS
cord-253501-hkxlq3os	62	2	,	,	,
cord-253501-hkxlq3os	62	3	B	b	NN
cord-253501-hkxlq3os	62	4	,	,	,
cord-253501-hkxlq3os	62	5	C	C	NNP
cord-253501-hkxlq3os	62	6	and	and	CC
cord-253501-hkxlq3os	62	7	D	D	NNP
cord-253501-hkxlq3os	62	8	represent	represent	VBP
cord-253501-hkxlq3os	62	9	the	the	DT
cord-253501-hkxlq3os	62	10	unknown	unknown	JJ
cord-253501-hkxlq3os	62	11	factors	factor	NNS
cord-253501-hkxlq3os	62	12	present	present	JJ
cord-253501-hkxlq3os	62	13	in	in	IN
cord-253501-hkxlq3os	62	14	the	the	DT
cord-253501-hkxlq3os	62	15	viral	viral	JJ
cord-253501-hkxlq3os	62	16	replication	replication	NN
cord-253501-hkxlq3os	62	17	complex	complex	NN
cord-253501-hkxlq3os	62	18	.	.	.
cord-253501-hkxlq3os	63	1	Note	note	VB
cord-253501-hkxlq3os	63	2	that	that	IN
cord-253501-hkxlq3os	63	3	ORF4	ORF4	NNP
cord-253501-hkxlq3os	63	4	is	be	VBZ
cord-253501-hkxlq3os	63	5	present	present	JJ
cord-253501-hkxlq3os	63	6	only	only	RB
cord-253501-hkxlq3os	63	7	in	in	IN
cord-253501-hkxlq3os	63	8	the	the	DT
cord-253501-hkxlq3os	63	9	case	case	NN
cord-253501-hkxlq3os	63	10	of	of	IN
cord-253501-hkxlq3os	63	11	genotype	genotype	NN
cord-253501-hkxlq3os	63	12	1	1	CD
cord-253501-hkxlq3os	63	13	HEV	hev	NN
cord-253501-hkxlq3os	63	14	.	.	.
cord-253501-hkxlq3os	64	1	Known	know	VBN
cord-253501-hkxlq3os	64	2	antivirals	antiviral	NNS
cord-253501-hkxlq3os	64	3	have	have	VBP
cord-253501-hkxlq3os	64	4	been	be	VBN
cord-253501-hkxlq3os	64	5	indicated	indicate	VBN
cord-253501-hkxlq3os	64	6	at	at	IN
cord-253501-hkxlq3os	64	7	the	the	DT
cord-253501-hkxlq3os	64	8	appropriate	appropriate	JJ
cord-253501-hkxlq3os	64	9	steps	step	NNS
cord-253501-hkxlq3os	64	10	.	.	.
cord-253501-hkxlq3os	65	1	The	the	DT
cord-253501-hkxlq3os	65	2	mode	mode	NN
cord-253501-hkxlq3os	65	3	of	of	IN
cord-253501-hkxlq3os	65	4	pegylated	pegylate	VBN
cord-253501-hkxlq3os	65	5	-	-	HYPH
cord-253501-hkxlq3os	65	6	interferon	interferon	NN
cord-253501-hkxlq3os	65	7	-	-	HYPH
cord-253501-hkxlq3os	65	8	alpha	alpha	NN
cord-253501-hkxlq3os	65	9	(	(	-LRB-
cord-253501-hkxlq3os	65	10	PEG	PEG	NNP
cord-253501-hkxlq3os	65	11	-	-	HYPH
cord-253501-hkxlq3os	65	12	IFN	IFN	NNP
cord-253501-hkxlq3os	65	13	-	-	HYPH
cord-253501-hkxlq3os	65	14	a	a	DT
cord-253501-hkxlq3os	65	15	)	)	-RRB-
cord-253501-hkxlq3os	65	16	action	action	NN
cord-253501-hkxlq3os	65	17	is	be	VBZ
cord-253501-hkxlq3os	65	18	represented	represent	VBN
cord-253501-hkxlq3os	65	19	through	through	IN
cord-253501-hkxlq3os	65	20	the	the	DT
cord-253501-hkxlq3os	65	21	illustration	illustration	NN
cord-253501-hkxlq3os	65	22	of	of	IN
cord-253501-hkxlq3os	65	23	the	the	DT
cord-253501-hkxlq3os	65	24	inteferonalpha	inteferonalpha	NNP
cord-253501-hkxlq3os	65	25	(	(	-LRB-
cord-253501-hkxlq3os	65	26	IFN	IFN	NNP
cord-253501-hkxlq3os	65	27	-	-	HYPH
cord-253501-hkxlq3os	65	28	a	a	LS
cord-253501-hkxlq3os	65	29	)	)	-RRB-
cord-253501-hkxlq3os	65	30	signaling	signal	VBG
cord-253501-hkxlq3os	65	31	pathway	pathway	NN
cord-253501-hkxlq3os	65	32	.	.	.
cord-253501-hkxlq3os	66	1	PEG	PEG	NNP
cord-253501-hkxlq3os	66	2	-	-	HYPH
cord-253501-hkxlq3os	66	3	IFN	IFN	NNP
cord-253501-hkxlq3os	66	4	-	-	:
cord-253501-hkxlq3os	66	5	a	a	DT
cord-253501-hkxlq3os	66	6	induces	induce	VBZ
cord-253501-hkxlq3os	66	7	the	the	DT
cord-253501-hkxlq3os	66	8	production	production	NN
cord-253501-hkxlq3os	66	9	of	of	IN
cord-253501-hkxlq3os	66	10	interferon	interferon	NN
cord-253501-hkxlq3os	66	11	-	-	HYPH
cord-253501-hkxlq3os	66	12	stimulated	stimulate	VBN
cord-253501-hkxlq3os	66	13	proteins	protein	NNS
cord-253501-hkxlq3os	66	14	(	(	-LRB-
cord-253501-hkxlq3os	66	15	ISGs	ISGs	NNP
cord-253501-hkxlq3os	66	16	)	)	-RRB-
cord-253501-hkxlq3os	66	17	and	and	CC
cord-253501-hkxlq3os	66	18	interferon	interferon	NN
cord-253501-hkxlq3os	66	19	-	-	HYPH
cord-253501-hkxlq3os	66	20	inducible	inducible	JJ
cord-253501-hkxlq3os	66	21	transmemebrane	transmemebrane	NN
cord-253501-hkxlq3os	66	22	proteins	protein	NNS
cord-253501-hkxlq3os	66	23	(	(	-LRB-
cord-253501-hkxlq3os	66	24	IFITM	IFITM	NNP
cord-253501-hkxlq3os	66	25	)	)	-RRB-
cord-253501-hkxlq3os	66	26	,	,	,
cord-253501-hkxlq3os	66	27	which	which	WDT
cord-253501-hkxlq3os	66	28	activate	activate	VBP
cord-253501-hkxlq3os	66	29	the	the	DT
cord-253501-hkxlq3os	66	30	canonical	canonical	JJ
cord-253501-hkxlq3os	66	31	antiviral	antiviral	JJ
cord-253501-hkxlq3os	66	32	signaling	signal	VBG
cord-253501-hkxlq3os	66	33	pathways	pathway	NNS
cord-253501-hkxlq3os	66	34	that	that	WDT
cord-253501-hkxlq3os	66	35	results	result	VBZ
cord-253501-hkxlq3os	66	36	in	in	IN
cord-253501-hkxlq3os	66	37	the	the	DT
cord-253501-hkxlq3os	66	38	inhibition	inhibition	NN
cord-253501-hkxlq3os	66	39	of	of	IN
cord-253501-hkxlq3os	66	40	HEV	HEV	NNP
cord-253501-hkxlq3os	66	41	entry	entry	NN
cord-253501-hkxlq3os	66	42	and/or	and/or	CC
cord-253501-hkxlq3os	66	43	replication	replication	NN
cord-253501-hkxlq3os	66	44	.	.	.
cord-253501-hkxlq3os	67	1	Also	also	RB
cord-253501-hkxlq3os	67	2	of	of	IN
cord-253501-hkxlq3os	67	3	note	note	NN
cord-253501-hkxlq3os	67	4	is	be	VBZ
cord-253501-hkxlq3os	67	5	the	the	DT
cord-253501-hkxlq3os	67	6	fact	fact	NN
cord-253501-hkxlq3os	67	7	that	that	IN
cord-253501-hkxlq3os	67	8	although	although	IN
cord-253501-hkxlq3os	67	9	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	67	10	treatment	treatment	NN
cord-253501-hkxlq3os	67	11	for	for	IN
cord-253501-hkxlq3os	67	12	chronic	chronic	JJ
cord-253501-hkxlq3os	67	13	HEV	hev	NN
cord-253501-hkxlq3os	67	14	-	-	HYPH
cord-253501-hkxlq3os	67	15	infected	infect	VBN
cord-253501-hkxlq3os	67	16	organ	organ	NN
cord-253501-hkxlq3os	67	17	transplantation	transplantation	NN
cord-253501-hkxlq3os	67	18	recipients	recipient	NNS
cord-253501-hkxlq3os	67	19	is	be	VBZ
cord-253501-hkxlq3os	67	20	effective	effective	JJ
cord-253501-hkxlq3os	67	21	in	in	IN
cord-253501-hkxlq3os	67	22	the	the	DT
cord-253501-hkxlq3os	67	23	majority	majority	NN
cord-253501-hkxlq3os	67	24	of	of	IN
cord-253501-hkxlq3os	67	25	cases	case	NNS
cord-253501-hkxlq3os	67	26	,	,	,
cord-253501-hkxlq3os	67	27	it	-PRON-	PRP
cord-253501-hkxlq3os	67	28	does	do	VBZ
cord-253501-hkxlq3os	67	29	not	not	RB
cord-253501-hkxlq3os	67	30	reach	reach	VB
cord-253501-hkxlq3os	67	31	a	a	DT
cord-253501-hkxlq3os	67	32	100	100	CD
cord-253501-hkxlq3os	67	33	%	%	NN
cord-253501-hkxlq3os	67	34	success	success	NN
cord-253501-hkxlq3os	67	35	rate	rate	NN
cord-253501-hkxlq3os	67	36	.	.	.
cord-253501-hkxlq3os	68	1	34	34	CD
cord-253501-hkxlq3os	69	1	Further	further	RB
cord-253501-hkxlq3os	69	2	,	,	,
cord-253501-hkxlq3os	69	3	in	in	IN
cord-253501-hkxlq3os	69	4	a	a	DT
cord-253501-hkxlq3os	69	5	study	study	NN
cord-253501-hkxlq3os	69	6	involving	involve	VBG
cord-253501-hkxlq3os	69	7	a	a	DT
cord-253501-hkxlq3os	69	8	chronic	chronic	JJ
cord-253501-hkxlq3os	69	9	HEV	hev	NN
cord-253501-hkxlq3os	69	10	-	-	HYPH
cord-253501-hkxlq3os	69	11	infected	infect	VBN
cord-253501-hkxlq3os	69	12	Burkitt	Burkitt	NNP
cord-253501-hkxlq3os	69	13	's	's	POS
cord-253501-hkxlq3os	69	14	lymphoma	lymphoma	NN
cord-253501-hkxlq3os	69	15	patient	patient	NN
cord-253501-hkxlq3os	69	16	treated	treat	VBN
cord-253501-hkxlq3os	69	17	with	with	IN
cord-253501-hkxlq3os	69	18	chemotherapy	chemotherapy	NN
cord-253501-hkxlq3os	69	19	,	,	,
cord-253501-hkxlq3os	69	20	8	8	CD
cord-253501-hkxlq3os	69	21	months	month	NNS
cord-253501-hkxlq3os	69	22	of	of	IN
cord-253501-hkxlq3os	69	23	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	69	24	treatment	treatment	NN
cord-253501-hkxlq3os	69	25	failed	fail	VBD
cord-253501-hkxlq3os	69	26	to	to	TO
cord-253501-hkxlq3os	69	27	eliminate	eliminate	VB
cord-253501-hkxlq3os	69	28	the	the	DT
cord-253501-hkxlq3os	69	29	HEV	hev	NN
cord-253501-hkxlq3os	69	30	.	.	.
cord-253501-hkxlq3os	70	1	14	14	CD
cord-253501-hkxlq3os	70	2	PEG	PEG	NNP
cord-253501-hkxlq3os	70	3	-	-	HYPH
cord-253501-hkxlq3os	70	4	IFN	IFN	NNP
cord-253501-hkxlq3os	70	5	-	-	HYPH
cord-253501-hkxlq3os	70	6	a	a	NNP
cord-253501-hkxlq3os	70	7	has	have	VBZ
cord-253501-hkxlq3os	70	8	been	be	VBN
cord-253501-hkxlq3os	70	9	used	use	VBN
cord-253501-hkxlq3os	70	10	in	in	IN
cord-253501-hkxlq3os	70	11	patients	patient	NNS
cord-253501-hkxlq3os	70	12	with	with	IN
cord-253501-hkxlq3os	70	13	liver	liver	NN
cord-253501-hkxlq3os	70	14	transplant	transplant	NN
cord-253501-hkxlq3os	70	15	,	,	,
cord-253501-hkxlq3os	70	16	kidney	kidney	NN
cord-253501-hkxlq3os	70	17	transplant	transplant	NN
cord-253501-hkxlq3os	70	18	,	,	,
cord-253501-hkxlq3os	70	19	human	human	JJ
cord-253501-hkxlq3os	70	20	immunodeficiency	immunodeficiency	NN
cord-253501-hkxlq3os	70	21	virus	virus	NN
cord-253501-hkxlq3os	70	22	infection	infection	NN
cord-253501-hkxlq3os	70	23	and	and	CC
cord-253501-hkxlq3os	70	24	leukemia	leukemia	NN
cord-253501-hkxlq3os	70	25	who	who	WP
cord-253501-hkxlq3os	70	26	are	be	VBP
cord-253501-hkxlq3os	70	27	chronically	chronically	RB
cord-253501-hkxlq3os	70	28	infected	infect	VBN
cord-253501-hkxlq3os	70	29	with	with	IN
cord-253501-hkxlq3os	70	30	HEV	HEV	NNP
cord-253501-hkxlq3os	70	31	.	.	.
cord-253501-hkxlq3os	71	1	[	[	-LRB-
cord-253501-hkxlq3os	71	2	39	39	CD
cord-253501-hkxlq3os	71	3	]	]	-RRB-
cord-253501-hkxlq3os	71	4	[	[	-LRB-
cord-253501-hkxlq3os	71	5	40	40	CD
cord-253501-hkxlq3os	71	6	]	]	-RRB-
cord-253501-hkxlq3os	71	7	[	[	-LRB-
cord-253501-hkxlq3os	71	8	41	41	CD
cord-253501-hkxlq3os	71	9	]	]	-RRB-
cord-253501-hkxlq3os	72	1	[	[	-LRB-
cord-253501-hkxlq3os	72	2	42	42	CD
cord-253501-hkxlq3os	72	3	]	]	-RRB-
cord-253501-hkxlq3os	73	1	The	the	DT
cord-253501-hkxlq3os	73	2	mechanism	mechanism	NN
cord-253501-hkxlq3os	73	3	by	by	IN
cord-253501-hkxlq3os	73	4	which	which	WDT
cord-253501-hkxlq3os	73	5	PEG	PEG	NNP
cord-253501-hkxlq3os	73	6	-	-	HYPH
cord-253501-hkxlq3os	73	7	IFN	IFN	NNP
cord-253501-hkxlq3os	73	8	-	-	HYPH
cord-253501-hkxlq3os	73	9	a	a	DT
cord-253501-hkxlq3os	73	10	clears	clear	VBZ
cord-253501-hkxlq3os	73	11	HEV	hev	NN
cord-253501-hkxlq3os	73	12	is	be	VBZ
cord-253501-hkxlq3os	73	13	not	not	RB
cord-253501-hkxlq3os	73	14	clearly	clearly	RB
cord-253501-hkxlq3os	73	15	understood	understand	VBN
cord-253501-hkxlq3os	73	16	.	.	.
cord-253501-hkxlq3os	74	1	However	however	RB
cord-253501-hkxlq3os	74	2	,	,	,
cord-253501-hkxlq3os	74	3	all	all	PDT
cord-253501-hkxlq3os	74	4	the	the	DT
cord-253501-hkxlq3os	74	5	types	type	NNS
cord-253501-hkxlq3os	74	6	of	of	IN
cord-253501-hkxlq3os	74	7	IFN	IFN	NNP
cord-253501-hkxlq3os	74	8	,	,	,
cord-253501-hkxlq3os	74	9	including	include	VBG
cord-253501-hkxlq3os	74	10	IFN	IFN	NNP
cord-253501-hkxlq3os	74	11	-	-	HYPH
cord-253501-hkxlq3os	74	12	a	a	DT
cord-253501-hkxlq3os	74	13	(	(	-LRB-
cord-253501-hkxlq3os	74	14	type	type	NN
cord-253501-hkxlq3os	74	15	I	-PRON-	PRP
cord-253501-hkxlq3os	74	16	)	)	-RRB-
cord-253501-hkxlq3os	74	17	,	,	,
cord-253501-hkxlq3os	74	18	IFN	IFN	NNP
cord-253501-hkxlq3os	74	19	-	-	HYPH
cord-253501-hkxlq3os	74	20	g	g	NNP
cord-253501-hkxlq3os	74	21	(	(	-LRB-
cord-253501-hkxlq3os	74	22	type	type	NN
cord-253501-hkxlq3os	74	23	II	II	NNP
cord-253501-hkxlq3os	74	24	)	)	-RRB-
cord-253501-hkxlq3os	74	25	,	,	,
cord-253501-hkxlq3os	74	26	and	and	CC
cord-253501-hkxlq3os	74	27	IFN	IFN	NNP
cord-253501-hkxlq3os	74	28	-	-	HYPH
cord-253501-hkxlq3os	74	29	l3	l3	NNP
cord-253501-hkxlq3os	74	30	(	(	-LRB-
cord-253501-hkxlq3os	74	31	type	type	NN
cord-253501-hkxlq3os	74	32	III	III	NNP
cord-253501-hkxlq3os	74	33	)	)	-RRB-
cord-253501-hkxlq3os	74	34	inhibit	inhibit	VBP
cord-253501-hkxlq3os	74	35	HEV	HEV	NNP
cord-253501-hkxlq3os	74	36	replication	replication	NN
cord-253501-hkxlq3os	74	37	and	and	CC
cord-253501-hkxlq3os	74	38	IFN	IFN	NNP
cord-253501-hkxlq3os	74	39	-	-	:
cord-253501-hkxlq3os	74	40	a	a	DT
cord-253501-hkxlq3os	74	41	subtypes	subtypes	NN
cord-253501-hkxlq3os	75	1	2a	2a	NNP
cord-253501-hkxlq3os	75	2	and	and	CC
cord-253501-hkxlq3os	75	3	2b	2b	LS
cord-253501-hkxlq3os	75	4	exert	exert	VB
cord-253501-hkxlq3os	75	5	the	the	DT
cord-253501-hkxlq3os	75	6	strongest	strong	JJS
cord-253501-hkxlq3os	75	7	antiviral	antiviral	JJ
cord-253501-hkxlq3os	75	8	activity	activity	NN
cord-253501-hkxlq3os	75	9	against	against	IN
cord-253501-hkxlq3os	75	10	HEV	HEV	NNP
cord-253501-hkxlq3os	75	11	in	in	IN
cord-253501-hkxlq3os	75	12	mammalian	mammalian	JJ
cord-253501-hkxlq3os	75	13	cell	cell	NN
cord-253501-hkxlq3os	75	14	culture	culture	NN
cord-253501-hkxlq3os	75	15	.	.	.
cord-253501-hkxlq3os	76	1	43	43	CD
cord-253501-hkxlq3os	76	2	HEV	HEV	NNP
cord-253501-hkxlq3os	76	3	is	be	VBZ
cord-253501-hkxlq3os	76	4	also	also	RB
cord-253501-hkxlq3os	76	5	equipped	equip	VBN
cord-253501-hkxlq3os	76	6	with	with	IN
cord-253501-hkxlq3os	76	7	multiple	multiple	JJ
cord-253501-hkxlq3os	76	8	strategies	strategy	NNS
cord-253501-hkxlq3os	76	9	to	to	TO
cord-253501-hkxlq3os	76	10	restrict	restrict	VB
cord-253501-hkxlq3os	76	11	the	the	DT
cord-253501-hkxlq3os	76	12	IFN	IFN	NNP
cord-253501-hkxlq3os	76	13	response	response	NN
cord-253501-hkxlq3os	76	14	,	,	,
cord-253501-hkxlq3os	76	15	leading	lead	VBG
cord-253501-hkxlq3os	76	16	to	to	IN
cord-253501-hkxlq3os	76	17	moderate	moderate	JJ
cord-253501-hkxlq3os	76	18	and	and	CC
cord-253501-hkxlq3os	76	19	delayed	delayed	JJ
cord-253501-hkxlq3os	76	20	anti	anti	JJ
cord-253501-hkxlq3os	76	21	-	-	JJ
cord-253501-hkxlq3os	76	22	HEV	hev	JJ
cord-253501-hkxlq3os	76	23	effects	effect	NNS
cord-253501-hkxlq3os	76	24	in	in	IN
cord-253501-hkxlq3os	76	25	vitro	vitro	FW
cord-253501-hkxlq3os	76	26	and	and	CC
cord-253501-hkxlq3os	76	27	in	in	IN
cord-253501-hkxlq3os	76	28	patients	patient	NNS
cord-253501-hkxlq3os	76	29	treated	treat	VBN
cord-253501-hkxlq3os	76	30	with	with	IN
cord-253501-hkxlq3os	76	31	IFN	IFN	NNP
cord-253501-hkxlq3os	76	32	-	-	HYPH
cord-253501-hkxlq3os	76	33	a	a	NN
cord-253501-hkxlq3os	76	34	.	.	.
cord-253501-hkxlq3os	76	35	44	44	CD
cord-253501-hkxlq3os	77	1	The	the	DT
cord-253501-hkxlq3os	77	2	HEV	HEV	NNP
cord-253501-hkxlq3os	77	3	X	x	NN
cord-253501-hkxlq3os	77	4	and	and	CC
cord-253501-hkxlq3os	77	5	papain	papain	NN
cord-253501-hkxlq3os	77	6	-	-	HYPH
cord-253501-hkxlq3os	77	7	like	like	JJ
cord-253501-hkxlq3os	77	8	cysteine	cysteine	NN
cord-253501-hkxlq3os	77	9	protease	protease	NN
cord-253501-hkxlq3os	77	10	domains	domain	NNS
cord-253501-hkxlq3os	77	11	inhibit	inhibit	VBP
cord-253501-hkxlq3os	77	12	IFN	IFN	NNP
cord-253501-hkxlq3os	77	13	(	(	-LRB-
cord-253501-hkxlq3os	77	14	type	type	NN
cord-253501-hkxlq3os	77	15	I	i	NN
cord-253501-hkxlq3os	77	16	)	)	-RRB-
cord-253501-hkxlq3os	77	17	induction	induction	NN
cord-253501-hkxlq3os	77	18	,	,	,
cord-253501-hkxlq3os	77	19	while	while	IN
cord-253501-hkxlq3os	77	20	HEV	HEV	NNP
cord-253501-hkxlq3os	77	21	ORF3	ORF3	NNP
cord-253501-hkxlq3os	77	22	is	be	VBZ
cord-253501-hkxlq3os	77	23	known	know	VBN
cord-253501-hkxlq3os	77	24	to	to	TO
cord-253501-hkxlq3os	77	25	inhibit	inhibit	VB
cord-253501-hkxlq3os	77	26	IFN	IFN	NNP
cord-253501-hkxlq3os	77	27	-	-	:
cord-253501-hkxlq3os	77	28	a	a	DT
cord-253501-hkxlq3os	77	29	signaling	signaling	NN
cord-253501-hkxlq3os	77	30	by	by	IN
cord-253501-hkxlq3os	77	31	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	77	32	phosphorylation	phosphorylation	NN
cord-253501-hkxlq3os	77	33	of	of	IN
cord-253501-hkxlq3os	77	34	STAT1	stat1	NN
cord-253501-hkxlq3os	77	35	.	.	.
cord-253501-hkxlq3os	78	1	45	45	CD
cord-253501-hkxlq3os	78	2	,	,	,
cord-253501-hkxlq3os	78	3	46	46	CD
cord-253501-hkxlq3os	79	1	Interestingly	interestingly	RB
cord-253501-hkxlq3os	79	2	,	,	,
cord-253501-hkxlq3os	79	3	ORF3	ORF3	NNP
cord-253501-hkxlq3os	79	4	also	also	RB
cord-253501-hkxlq3os	79	5	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	79	6	phosphorylation	phosphorylation	NN
cord-253501-hkxlq3os	79	7	and	and	CC
cord-253501-hkxlq3os	79	8	nuclear	nuclear	JJ
cord-253501-hkxlq3os	79	9	translocation	translocation	NN
cord-253501-hkxlq3os	79	10	of	of	IN
cord-253501-hkxlq3os	79	11	STAT3	STAT3	NNP
cord-253501-hkxlq3os	79	12	as	as	RB
cord-253501-hkxlq3os	79	13	well	well	RB
cord-253501-hkxlq3os	79	14	as	as	IN
cord-253501-hkxlq3os	79	15	expression	expression	NN
cord-253501-hkxlq3os	79	16	of	of	IN
cord-253501-hkxlq3os	79	17	its	-PRON-	PRP$
cord-253501-hkxlq3os	79	18	target	target	NN
cord-253501-hkxlq3os	79	19	genes	gene	NNS
cord-253501-hkxlq3os	79	20	in	in	IN
cord-253501-hkxlq3os	79	21	cells	cell	NNS
cord-253501-hkxlq3os	79	22	treated	treat	VBN
cord-253501-hkxlq3os	79	23	with	with	IN
cord-253501-hkxlq3os	79	24	epidermal	epidermal	JJ
cord-253501-hkxlq3os	79	25	growth	growth	NN
cord-253501-hkxlq3os	79	26	factor	factor	NN
cord-253501-hkxlq3os	79	27	.	.	.
cord-253501-hkxlq3os	80	1	47	47	CD
cord-253501-hkxlq3os	81	1	Further	further	JJ
cord-253501-hkxlq3os	81	2	studies	study	NNS
cord-253501-hkxlq3os	81	3	using	use	VBG
cord-253501-hkxlq3os	81	4	suitable	suitable	JJ
cord-253501-hkxlq3os	81	5	in	in	IN
cord-253501-hkxlq3os	81	6	vivo	vivo	NN
cord-253501-hkxlq3os	81	7	models	model	NNS
cord-253501-hkxlq3os	81	8	should	should	MD
cord-253501-hkxlq3os	81	9	decipher	decipher	VB
cord-253501-hkxlq3os	81	10	the	the	DT
cord-253501-hkxlq3os	81	11	significance	significance	NN
cord-253501-hkxlq3os	81	12	of	of	IN
cord-253501-hkxlq3os	81	13	the	the	DT
cord-253501-hkxlq3os	81	14	crosstalk	crosstalk	NN
cord-253501-hkxlq3os	81	15	between	between	IN
cord-253501-hkxlq3os	81	16	host	host	NN
cord-253501-hkxlq3os	81	17	interferon	interferon	NN
cord-253501-hkxlq3os	81	18	signaling	signal	VBG
cord-253501-hkxlq3os	81	19	and	and	CC
cord-253501-hkxlq3os	81	20	the	the	DT
cord-253501-hkxlq3os	81	21	viral	viral	JJ
cord-253501-hkxlq3os	81	22	interferon	interferon	NN
cord-253501-hkxlq3os	81	23	restriction	restriction	NN
cord-253501-hkxlq3os	81	24	factors	factor	NNS
cord-253501-hkxlq3os	81	25	.	.	.
cord-253501-hkxlq3os	82	1	The	the	DT
cord-253501-hkxlq3os	82	2	common	common	JJ
cord-253501-hkxlq3os	82	3	side	side	NN
cord-253501-hkxlq3os	82	4	effect	effect	NN
cord-253501-hkxlq3os	82	5	associated	associate	VBN
cord-253501-hkxlq3os	82	6	with	with	IN
cord-253501-hkxlq3os	82	7	IFN	IFN	NNP
cord-253501-hkxlq3os	82	8	treatment	treatment	NN
cord-253501-hkxlq3os	82	9	is	be	VBZ
cord-253501-hkxlq3os	82	10	flu	flu	NN
cord-253501-hkxlq3os	82	11	-	-	HYPH
cord-253501-hkxlq3os	82	12	like	like	JJ
cord-253501-hkxlq3os	82	13	symptoms	symptom	NNS
cord-253501-hkxlq3os	82	14	.	.	.
cord-253501-hkxlq3os	83	1	Among	among	IN
cord-253501-hkxlq3os	83	2	the	the	DT
cord-253501-hkxlq3os	83	3	more	more	RBR
cord-253501-hkxlq3os	83	4	serious	serious	JJ
cord-253501-hkxlq3os	83	5	adverse	adverse	JJ
cord-253501-hkxlq3os	83	6	effects	effect	NNS
cord-253501-hkxlq3os	83	7	are	be	VBP
cord-253501-hkxlq3os	83	8	neuropsychiatric	neuropsychiatric	JJ
cord-253501-hkxlq3os	83	9	disorders	disorder	NNS
cord-253501-hkxlq3os	83	10	,	,	,
cord-253501-hkxlq3os	83	11	neurologic	neurologic	JJ
cord-253501-hkxlq3os	83	12	disturbances	disturbance	NNS
cord-253501-hkxlq3os	83	13	,	,	,
cord-253501-hkxlq3os	83	14	myelosuppression	myelosuppression	NN
cord-253501-hkxlq3os	83	15	,	,	,
cord-253501-hkxlq3os	83	16	cardiovascular	cardiovascular	JJ
cord-253501-hkxlq3os	83	17	disorders	disorder	NNS
cord-253501-hkxlq3os	83	18	,	,	,
cord-253501-hkxlq3os	83	19	altered	alter	VBN
cord-253501-hkxlq3os	83	20	liver	liver	NN
cord-253501-hkxlq3os	83	21	function	function	NN
cord-253501-hkxlq3os	83	22	,	,	,
cord-253501-hkxlq3os	83	23	renal	renal	JJ
cord-253501-hkxlq3os	83	24	insufficiency	insufficiency	NN
cord-253501-hkxlq3os	83	25	and	and	CC
cord-253501-hkxlq3os	83	26	gastrointestinal	gastrointestinal	JJ
cord-253501-hkxlq3os	83	27	manifestations	manifestation	NNS
cord-253501-hkxlq3os	83	28	.	.	.
cord-253501-hkxlq3os	84	1	48	48	CD
cord-253501-hkxlq3os	85	1	Further	further	RB
cord-253501-hkxlq3os	85	2	,	,	,
cord-253501-hkxlq3os	85	3	3	3	CD
cord-253501-hkxlq3os	85	4	months	month	NNS
cord-253501-hkxlq3os	85	5	of	of	IN
cord-253501-hkxlq3os	85	6	treatment	treatment	NN
cord-253501-hkxlq3os	85	7	with	with	IN
cord-253501-hkxlq3os	85	8	PEG	PEG	NNP
cord-253501-hkxlq3os	85	9	-	-	HYPH
cord-253501-hkxlq3os	85	10	IFN	IFN	NNP
cord-253501-hkxlq3os	85	11	-	-	HYPH
cord-253501-hkxlq3os	85	12	a-2a	a-2a	CD
cord-253501-hkxlq3os	85	13	is	be	VBZ
cord-253501-hkxlq3os	85	14	reported	report	VBN
cord-253501-hkxlq3os	85	15	to	to	TO
cord-253501-hkxlq3os	85	16	result	result	VB
cord-253501-hkxlq3os	85	17	in	in	IN
cord-253501-hkxlq3os	85	18	sustained	sustained	JJ
cord-253501-hkxlq3os	85	19	virolgical	virolgical	JJ
cord-253501-hkxlq3os	85	20	response	response	NN
cord-253501-hkxlq3os	85	21	in	in	IN
cord-253501-hkxlq3os	85	22	2	2	CD
cord-253501-hkxlq3os	85	23	out	out	IN
cord-253501-hkxlq3os	85	24	of	of	IN
cord-253501-hkxlq3os	85	25	3	3	CD
cord-253501-hkxlq3os	85	26	chronic	chronic	JJ
cord-253501-hkxlq3os	85	27	HEV	hev	NN
cord-253501-hkxlq3os	85	28	-	-	HYPH
cord-253501-hkxlq3os	85	29	infected	infect	VBN
cord-253501-hkxlq3os	85	30	liver	liver	NN
cord-253501-hkxlq3os	85	31	transplant	transplant	NN
cord-253501-hkxlq3os	85	32	patients	patient	NNS
cord-253501-hkxlq3os	85	33	.	.	.
cord-253501-hkxlq3os	86	1	49	49	CD
cord-253501-hkxlq3os	87	1	In	in	IN
cord-253501-hkxlq3os	87	2	summary	summary	NN
cord-253501-hkxlq3os	87	3	,	,	,
cord-253501-hkxlq3os	87	4	PEG	PEG	NNP
cord-253501-hkxlq3os	87	5	-	-	HYPH
cord-253501-hkxlq3os	87	6	IFN	IFN	NNP
cord-253501-hkxlq3os	87	7	-	-	:
cord-253501-hkxlq3os	87	8	a	a	DT
cord-253501-hkxlq3os	87	9	treatment	treatment	NN
cord-253501-hkxlq3os	87	10	appears	appear	VBZ
cord-253501-hkxlq3os	87	11	to	to	TO
cord-253501-hkxlq3os	87	12	be	be	VB
cord-253501-hkxlq3os	87	13	a	a	DT
cord-253501-hkxlq3os	87	14	promising	promising	JJ
cord-253501-hkxlq3os	87	15	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	87	16	option	option	NN
cord-253501-hkxlq3os	87	17	against	against	IN
cord-253501-hkxlq3os	87	18	HEV	HEV	NNP
cord-253501-hkxlq3os	87	19	infection	infection	NN
cord-253501-hkxlq3os	87	20	.	.	.
cord-253501-hkxlq3os	88	1	Nevertheless	nevertheless	RB
cord-253501-hkxlq3os	88	2	,	,	,
cord-253501-hkxlq3os	88	3	additional	additional	JJ
cord-253501-hkxlq3os	88	4	studies	study	NNS
cord-253501-hkxlq3os	88	5	involving	involve	VBG
cord-253501-hkxlq3os	88	6	large	large	JJ
cord-253501-hkxlq3os	88	7	cohorts	cohort	NNS
cord-253501-hkxlq3os	88	8	of	of	IN
cord-253501-hkxlq3os	88	9	patients	patient	NNS
cord-253501-hkxlq3os	88	10	should	should	MD
cord-253501-hkxlq3os	88	11	provide	provide	VB
cord-253501-hkxlq3os	88	12	a	a	DT
cord-253501-hkxlq3os	88	13	better	well	JJR
cord-253501-hkxlq3os	88	14	understanding	understanding	NN
cord-253501-hkxlq3os	88	15	of	of	IN
cord-253501-hkxlq3os	88	16	its	-PRON-	PRP$
cord-253501-hkxlq3os	88	17	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	88	18	benefits	benefit	NNS
cord-253501-hkxlq3os	88	19	.	.	.
cord-253501-hkxlq3os	89	1	Several	several	JJ
cord-253501-hkxlq3os	89	2	laboratories	laboratory	NNS
cord-253501-hkxlq3os	89	3	have	have	VBP
cord-253501-hkxlq3os	89	4	been	be	VBN
cord-253501-hkxlq3os	89	5	focusing	focus	VBG
cord-253501-hkxlq3os	89	6	on	on	IN
cord-253501-hkxlq3os	89	7	identifying	identify	VBG
cord-253501-hkxlq3os	89	8	suitable	suitable	JJ
cord-253501-hkxlq3os	89	9	drug	drug	NN
cord-253501-hkxlq3os	89	10	targets	target	NNS
cord-253501-hkxlq3os	89	11	and	and	CC
cord-253501-hkxlq3os	89	12	developing	develop	VBG
cord-253501-hkxlq3os	89	13	antivirals	antiviral	NNS
cord-253501-hkxlq3os	89	14	against	against	IN
cord-253501-hkxlq3os	89	15	HEV	HEV	NNP
cord-253501-hkxlq3os	89	16	.	.	.
cord-253501-hkxlq3os	90	1	50	50	CD
cord-253501-hkxlq3os	91	1	Summarized	summarize	VBN
cord-253501-hkxlq3os	91	2	below	below	RB
cord-253501-hkxlq3os	91	3	is	be	VBZ
cord-253501-hkxlq3os	91	4	the	the	DT
cord-253501-hkxlq3os	91	5	outcome	outcome	NN
cord-253501-hkxlq3os	91	6	of	of	IN
cord-253501-hkxlq3os	91	7	recent	recent	JJ
cord-253501-hkxlq3os	91	8	efforts	effort	NNS
cord-253501-hkxlq3os	91	9	to	to	TO
cord-253501-hkxlq3os	91	10	identify	identify	VB
cord-253501-hkxlq3os	91	11	potent	potent	JJ
cord-253501-hkxlq3os	91	12	antivirals	antiviral	NNS
cord-253501-hkxlq3os	91	13	against	against	IN
cord-253501-hkxlq3os	91	14	HEV	HEV	NNP
cord-253501-hkxlq3os	91	15	.	.	.
cord-253501-hkxlq3os	92	1	Inosine	Inosine	NNP
cord-253501-hkxlq3os	92	2	monophosphate	monophosphate	NN
cord-253501-hkxlq3os	92	3	dehydrogenase	dehydrogenase	NN
cord-253501-hkxlq3os	92	4	is	be	VBZ
cord-253501-hkxlq3os	92	5	an	an	DT
cord-253501-hkxlq3os	92	6	essential	essential	JJ
cord-253501-hkxlq3os	92	7	enzyme	enzyme	NN
cord-253501-hkxlq3os	92	8	in	in	IN
cord-253501-hkxlq3os	92	9	the	the	DT
cord-253501-hkxlq3os	92	10	purine	purine	NNP
cord-253501-hkxlq3os	92	11	biosynthesis	biosynthesis	NN
cord-253501-hkxlq3os	92	12	pathway	pathway	NN
cord-253501-hkxlq3os	92	13	.	.	.
cord-253501-hkxlq3os	93	1	Several	several	JJ
cord-253501-hkxlq3os	93	2	inosine	inosine	NN
cord-253501-hkxlq3os	93	3	monophosphate	monophosphate	NN
cord-253501-hkxlq3os	93	4	dehydrogenase	dehydrogenase	NN
cord-253501-hkxlq3os	93	5	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	93	6	,	,	,
cord-253501-hkxlq3os	93	7	such	such	JJ
cord-253501-hkxlq3os	93	8	as	as	IN
cord-253501-hkxlq3os	93	9	mycophenolic	mycophenolic	JJ
cord-253501-hkxlq3os	93	10	acid	acid	NN
cord-253501-hkxlq3os	93	11	,	,	,
cord-253501-hkxlq3os	93	12	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	93	13	and	and	CC
cord-253501-hkxlq3os	93	14	5-ethynyl-1-b	5-ethynyl-1-b	NN
cord-253501-hkxlq3os	93	15	-	-	HYPH
cord-253501-hkxlq3os	93	16	D	d	NN
cord-253501-hkxlq3os	93	17	-	-	HYPH
cord-253501-hkxlq3os	93	18	ribofuranosylimidazole-4carboxamide	ribofuranosylimidazole-4carboxamide	NN
cord-253501-hkxlq3os	93	19	,	,	,
cord-253501-hkxlq3os	93	20	inhibit	inhibit	VB
cord-253501-hkxlq3os	93	21	HEV	HEV	NNP
cord-253501-hkxlq3os	93	22	replication	replication	NN
cord-253501-hkxlq3os	93	23	.	.	.
cord-253501-hkxlq3os	94	1	33	33	CD
cord-253501-hkxlq3os	94	2	,	,	,
cord-253501-hkxlq3os	94	3	51	51	CD
cord-253501-hkxlq3os	95	1	The	the	DT
cord-253501-hkxlq3os	95	2	combination	combination	NN
cord-253501-hkxlq3os	95	3	of	of	IN
cord-253501-hkxlq3os	95	4	mycophenolic	mycophenolic	JJ
cord-253501-hkxlq3os	95	5	acid	acid	NN
cord-253501-hkxlq3os	95	6	and	and	CC
cord-253501-hkxlq3os	95	7	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	95	8	acts	act	VBZ
cord-253501-hkxlq3os	95	9	more	more	RBR
cord-253501-hkxlq3os	95	10	effectively	effectively	RB
cord-253501-hkxlq3os	95	11	to	to	TO
cord-253501-hkxlq3os	95	12	inhibit	inhibit	VB
cord-253501-hkxlq3os	95	13	HEV	HEV	NNP
cord-253501-hkxlq3os	95	14	replication	replication	NN
cord-253501-hkxlq3os	95	15	than	than	IN
cord-253501-hkxlq3os	95	16	mycophenolic	mycophenolic	JJ
cord-253501-hkxlq3os	95	17	acid	acid	NN
cord-253501-hkxlq3os	95	18	or	or	CC
cord-253501-hkxlq3os	95	19	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	95	20	alone	alone	RB
cord-253501-hkxlq3os	95	21	.	.	.
cord-253501-hkxlq3os	96	1	51	51	CD
cord-253501-hkxlq3os	97	1	Further	further	RB
cord-253501-hkxlq3os	97	2	,	,	,
cord-253501-hkxlq3os	97	3	mycophenolate	mycophenolate	NNP
cord-253501-hkxlq3os	97	4	mofetil	mofetil	NNP
cord-253501-hkxlq3os	97	5	,	,	,
cord-253501-hkxlq3os	97	6	a	a	DT
cord-253501-hkxlq3os	97	7	prodrug	prodrug	NN
cord-253501-hkxlq3os	97	8	of	of	IN
cord-253501-hkxlq3os	97	9	mycophenolic	mycophenolic	JJ
cord-253501-hkxlq3os	97	10	acid	acid	NN
cord-253501-hkxlq3os	97	11	,	,	,
cord-253501-hkxlq3os	97	12	exhibited	exhibit	VBD
cord-253501-hkxlq3os	97	13	frequent	frequent	JJ
cord-253501-hkxlq3os	97	14	HEV	hev	NN
cord-253501-hkxlq3os	97	15	clearance	clearance	NN
cord-253501-hkxlq3os	97	16	in	in	IN
cord-253501-hkxlq3os	97	17	heart	heart	NN
cord-253501-hkxlq3os	97	18	transplant	transplant	NN
cord-253501-hkxlq3os	97	19	patients	patient	NNS
cord-253501-hkxlq3os	97	20	,	,	,
cord-253501-hkxlq3os	97	21	providing	provide	VBG
cord-253501-hkxlq3os	97	22	protection	protection	NN
cord-253501-hkxlq3os	97	23	from	from	IN
cord-253501-hkxlq3os	97	24	chronification	chronification	NN
cord-253501-hkxlq3os	97	25	.	.	.
cord-253501-hkxlq3os	98	1	51	51	CD
cord-253501-hkxlq3os	99	1	Dihydroorotate	Dihydroorotate	NNP
cord-253501-hkxlq3os	99	2	dehydrogenase	dehydrogenase	NN
cord-253501-hkxlq3os	99	3	and	and	CC
cord-253501-hkxlq3os	99	4	orotidine-5'-monophosphate	orotidine-5'-monophosphate	JJ
cord-253501-hkxlq3os	99	5	decarboxylase	decarboxylase	NN
cord-253501-hkxlq3os	99	6	are	be	VBP
cord-253501-hkxlq3os	99	7	essential	essential	JJ
cord-253501-hkxlq3os	99	8	enzymes	enzyme	NNS
cord-253501-hkxlq3os	99	9	in	in	IN
cord-253501-hkxlq3os	99	10	the	the	DT
cord-253501-hkxlq3os	99	11	pyrimidine	pyrimidine	NNP
cord-253501-hkxlq3os	99	12	biosynthesis	biosynthesis	NN
cord-253501-hkxlq3os	99	13	pathway	pathway	NN
cord-253501-hkxlq3os	99	14	.	.	.
cord-253501-hkxlq3os	100	1	Dihydroorotate	Dihydroorotate	NNP
cord-253501-hkxlq3os	100	2	dehydrogenase	dehydrogenase	NN
cord-253501-hkxlq3os	100	3	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	100	4	,	,	,
cord-253501-hkxlq3os	100	5	such	such	JJ
cord-253501-hkxlq3os	100	6	as	as	IN
cord-253501-hkxlq3os	100	7	brequinar	brequinar	NNP
cord-253501-hkxlq3os	100	8	,	,	,
cord-253501-hkxlq3os	100	9	leflunomide	leflunomide	NNP
cord-253501-hkxlq3os	100	10	and	and	CC
cord-253501-hkxlq3os	100	11	orotidine-5'-monophosphate	orotidine-5'-monophosphate	NNP
cord-253501-hkxlq3os	100	12	decarboxylase	decarboxylase	NN
cord-253501-hkxlq3os	100	13	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	101	1	6-azauracil	6-azauracil	CD
cord-253501-hkxlq3os	101	2	,	,	,
cord-253501-hkxlq3os	101	3	also	also	RB
cord-253501-hkxlq3os	101	4	inhibit	inhibit	VB
cord-253501-hkxlq3os	101	5	HEV	HEV	NNP
cord-253501-hkxlq3os	101	6	replication	replication	NN
cord-253501-hkxlq3os	101	7	in	in	IN
cord-253501-hkxlq3os	101	8	mammalian	mammalian	JJ
cord-253501-hkxlq3os	101	9	cell	cell	NN
cord-253501-hkxlq3os	101	10	culture	culture	NN
cord-253501-hkxlq3os	101	11	models	model	NNS
cord-253501-hkxlq3os	101	12	.	.	.
cord-253501-hkxlq3os	102	1	52	52	CD
cord-253501-hkxlq3os	103	1	These	these	DT
cord-253501-hkxlq3os	103	2	compounds	compound	NNS
cord-253501-hkxlq3os	103	3	deserve	deserve	VBP
cord-253501-hkxlq3os	103	4	further	further	JJ
cord-253501-hkxlq3os	103	5	validation	validation	NN
cord-253501-hkxlq3os	103	6	as	as	IN
cord-253501-hkxlq3os	103	7	antivirals	antiviral	NNS
cord-253501-hkxlq3os	103	8	against	against	IN
cord-253501-hkxlq3os	103	9	HEV	HEV	NNP
cord-253501-hkxlq3os	103	10	.	.	.
cord-253501-hkxlq3os	104	1	2'-C	2'-c	CD
cord-253501-hkxlq3os	104	2	-	-	HYPH
cord-253501-hkxlq3os	104	3	methylcytidine	methylcytidine	NN
cord-253501-hkxlq3os	104	4	is	be	VBZ
cord-253501-hkxlq3os	104	5	a	a	DT
cord-253501-hkxlq3os	104	6	nucleoside	nucleoside	NN
cord-253501-hkxlq3os	104	7	analogue	analogue	NN
cord-253501-hkxlq3os	104	8	that	that	WDT
cord-253501-hkxlq3os	104	9	efficiently	efficiently	RB
cord-253501-hkxlq3os	104	10	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	104	11	HEV	HEV	NNP
cord-253501-hkxlq3os	104	12	replication	replication	NN
cord-253501-hkxlq3os	104	13	in	in	IN
cord-253501-hkxlq3os	104	14	the	the	DT
cord-253501-hkxlq3os	104	15	cell	cell	NN
cord-253501-hkxlq3os	104	16	culture	culture	NN
cord-253501-hkxlq3os	104	17	system	system	NN
cord-253501-hkxlq3os	104	18	.	.	.
cord-253501-hkxlq3os	105	1	53	53	CD
cord-253501-hkxlq3os	106	1	It	-PRON-	PRP
cord-253501-hkxlq3os	106	2	was	be	VBD
cord-253501-hkxlq3os	106	3	also	also	RB
cord-253501-hkxlq3os	106	4	shown	show	VBN
cord-253501-hkxlq3os	106	5	that	that	IN
cord-253501-hkxlq3os	106	6	2'-C	2'-c	CD
cord-253501-hkxlq3os	106	7	-	-	HYPH
cord-253501-hkxlq3os	106	8	methylcytidine	methylcytidine	NN
cord-253501-hkxlq3os	106	9	retained	retain	VBN
cord-253501-hkxlq3os	106	10	anti	anti	JJ
cord-253501-hkxlq3os	106	11	-	-	JJ
cord-253501-hkxlq3os	106	12	HEV	hev	JJ
cord-253501-hkxlq3os	106	13	activity	activity	NN
cord-253501-hkxlq3os	106	14	even	even	RB
cord-253501-hkxlq3os	106	15	after	after	IN
cord-253501-hkxlq3os	106	16	long	long	JJ
cord-253501-hkxlq3os	106	17	-	-	HYPH
cord-253501-hkxlq3os	106	18	term	term	NN
cord-253501-hkxlq3os	106	19	exposure	exposure	NN
cord-253501-hkxlq3os	106	20	to	to	IN
cord-253501-hkxlq3os	106	21	the	the	DT
cord-253501-hkxlq3os	106	22	virus	virus	NN
cord-253501-hkxlq3os	106	23	,	,	,
cord-253501-hkxlq3os	106	24	implying	imply	VBG
cord-253501-hkxlq3os	106	25	its	-PRON-	PRP$
cord-253501-hkxlq3os	106	26	potential	potential	JJ
cord-253501-hkxlq3os	106	27	use	use	NN
cord-253501-hkxlq3os	106	28	to	to	IN
cord-253501-hkxlq3os	106	29	combat	combat	VB
cord-253501-hkxlq3os	106	30	development	development	NN
cord-253501-hkxlq3os	106	31	of	of	IN
cord-253501-hkxlq3os	106	32	drug	drug	NN
cord-253501-hkxlq3os	106	33	resistance	resistance	NN
cord-253501-hkxlq3os	106	34	.	.	.
cord-253501-hkxlq3os	107	1	53	53	CD
cord-253501-hkxlq3os	108	1	However	however	RB
cord-253501-hkxlq3os	108	2	,	,	,
cord-253501-hkxlq3os	108	3	2'-C	2'-c	CD
cord-253501-hkxlq3os	108	4	-	-	HYPH
cord-253501-hkxlq3os	108	5	methylcytidine	methylcytidine	NN
cord-253501-hkxlq3os	108	6	showed	show	VBD
cord-253501-hkxlq3os	108	7	an	an	DT
cord-253501-hkxlq3os	108	8	antagonistic	antagonistic	JJ
cord-253501-hkxlq3os	108	9	effect	effect	NN
cord-253501-hkxlq3os	108	10	when	when	WRB
cord-253501-hkxlq3os	108	11	tested	test	VBN
cord-253501-hkxlq3os	108	12	in	in	IN
cord-253501-hkxlq3os	108	13	combination	combination	NN
cord-253501-hkxlq3os	108	14	therapy	therapy	NN
cord-253501-hkxlq3os	108	15	with	with	IN
cord-253501-hkxlq3os	108	16	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	108	17	.	.	.
cord-253501-hkxlq3os	109	1	53	53	CD
cord-253501-hkxlq3os	110	1	Further	further	RB
cord-253501-hkxlq3os	110	2	in	in	IN
cord-253501-hkxlq3os	110	3	vivo	vivo	NN
cord-253501-hkxlq3os	110	4	evaluation	evaluation	NN
cord-253501-hkxlq3os	110	5	of	of	IN
cord-253501-hkxlq3os	110	6	this	this	DT
cord-253501-hkxlq3os	110	7	compound	compound	NN
cord-253501-hkxlq3os	110	8	should	should	MD
cord-253501-hkxlq3os	110	9	provide	provide	VB
cord-253501-hkxlq3os	110	10	insights	insight	NNS
cord-253501-hkxlq3os	110	11	about	about	IN
cord-253501-hkxlq3os	110	12	its	-PRON-	PRP$
cord-253501-hkxlq3os	110	13	anti	anti	JJ
cord-253501-hkxlq3os	110	14	-	-	JJ
cord-253501-hkxlq3os	110	15	HEV	hev	JJ
cord-253501-hkxlq3os	110	16	effects	effect	NNS
cord-253501-hkxlq3os	110	17	.	.	.
cord-253501-hkxlq3os	111	1	Sofosbuvir	Sofosbuvir	NNP
cord-253501-hkxlq3os	111	2	,	,	,
cord-253501-hkxlq3os	111	3	a	a	DT
cord-253501-hkxlq3os	111	4	prodrug	prodrug	NN
cord-253501-hkxlq3os	111	5	of	of	IN
cord-253501-hkxlq3os	111	6	a	a	DT
cord-253501-hkxlq3os	111	7	uridine	uridine	JJ
cord-253501-hkxlq3os	111	8	nucleoside	nucleoside	NN
cord-253501-hkxlq3os	111	9	analogue	analogue	NN
cord-253501-hkxlq3os	111	10	that	that	WDT
cord-253501-hkxlq3os	111	11	acts	act	VBZ
cord-253501-hkxlq3os	111	12	as	as	IN
cord-253501-hkxlq3os	111	13	a	a	DT
cord-253501-hkxlq3os	111	14	direct	direct	JJ
cord-253501-hkxlq3os	111	15	-	-	HYPH
cord-253501-hkxlq3os	111	16	acting	acting	NN
cord-253501-hkxlq3os	111	17	antiviral	antiviral	JJ
cord-253501-hkxlq3os	111	18	against	against	IN
cord-253501-hkxlq3os	111	19	hepatitis	hepatitis	NNP
cord-253501-hkxlq3os	111	20	C	C	NNP
cord-253501-hkxlq3os	111	21	virus	virus	NN
cord-253501-hkxlq3os	111	22	(	(	-LRB-
cord-253501-hkxlq3os	111	23	HCV	HCV	NNP
cord-253501-hkxlq3os	111	24	)	)	-RRB-
cord-253501-hkxlq3os	111	25	RNA	RNA	NNP
cord-253501-hkxlq3os	111	26	-	-	HYPH
cord-253501-hkxlq3os	111	27	dependent	dependent	JJ
cord-253501-hkxlq3os	111	28	RNA	RNA	NNP
cord-253501-hkxlq3os	111	29	polymerase	polymerase	NN
cord-253501-hkxlq3os	111	30	in	in	IN
cord-253501-hkxlq3os	111	31	its	-PRON-	PRP$
cord-253501-hkxlq3os	111	32	active	active	JJ
cord-253501-hkxlq3os	111	33	form	form	NN
cord-253501-hkxlq3os	111	34	,	,	,
cord-253501-hkxlq3os	111	35	was	be	VBD
cord-253501-hkxlq3os	111	36	reported	report	VBN
cord-253501-hkxlq3os	111	37	by	by	IN
cord-253501-hkxlq3os	111	38	Dao	Dao	NNP
cord-253501-hkxlq3os	111	39	Thi	Thi	NNP
cord-253501-hkxlq3os	111	40	et	et	FW
cord-253501-hkxlq3os	111	41	al	al	NNP
cord-253501-hkxlq3os	111	42	.	.	.
cord-253501-hkxlq3os	112	1	54	54	CD
cord-253501-hkxlq3os	113	1	to	to	TO
cord-253501-hkxlq3os	113	2	inhibit	inhibit	VB
cord-253501-hkxlq3os	113	3	HEV	HEV	NNP
cord-253501-hkxlq3os	113	4	genotype	genotype	NN
cord-253501-hkxlq3os	113	5	3	3	CD
cord-253501-hkxlq3os	113	6	replication	replication	NN
cord-253501-hkxlq3os	113	7	in	in	IN
cord-253501-hkxlq3os	113	8	vitro	vitro	FW
cord-253501-hkxlq3os	113	9	and	and	CC
cord-253501-hkxlq3os	113	10	to	to	TO
cord-253501-hkxlq3os	113	11	exert	exert	VB
cord-253501-hkxlq3os	113	12	additive	additive	NN
cord-253501-hkxlq3os	113	13	effect	effect	NN
cord-253501-hkxlq3os	113	14	when	when	WRB
cord-253501-hkxlq3os	113	15	combined	combine	VBN
cord-253501-hkxlq3os	113	16	with	with	IN
cord-253501-hkxlq3os	113	17	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	113	18	.	.	.
cord-253501-hkxlq3os	114	1	However	however	RB
cord-253501-hkxlq3os	114	2	,	,	,
cord-253501-hkxlq3os	114	3	those	those	DT
cord-253501-hkxlq3os	114	4	data	datum	NNS
cord-253501-hkxlq3os	114	5	were	be	VBD
cord-253501-hkxlq3os	114	6	not	not	RB
cord-253501-hkxlq3os	114	7	fully	fully	RB
cord-253501-hkxlq3os	114	8	reproducible	reproducible	JJ
cord-253501-hkxlq3os	114	9	by	by	IN
cord-253501-hkxlq3os	114	10	Wang	Wang	NNP
cord-253501-hkxlq3os	114	11	et	et	NNP
cord-253501-hkxlq3os	114	12	al	al	NNP
cord-253501-hkxlq3os	114	13	.	.	.
cord-253501-hkxlq3os	115	1	55	55	CD
cord-253501-hkxlq3os	116	1	and	and	CC
cord-253501-hkxlq3os	116	2	,	,	,
cord-253501-hkxlq3os	116	3	moreover	moreover	RB
cord-253501-hkxlq3os	116	4	,	,	,
cord-253501-hkxlq3os	116	5	sofosbuvir	sofosbuvir	NNP
cord-253501-hkxlq3os	116	6	treatment	treatment	NN
cord-253501-hkxlq3os	116	7	failed	fail	VBD
cord-253501-hkxlq3os	116	8	to	to	TO
cord-253501-hkxlq3os	116	9	clear	clear	VB
cord-253501-hkxlq3os	116	10	HEV	HEV	NNP
cord-253501-hkxlq3os	116	11	viremia	viremia	NN
cord-253501-hkxlq3os	116	12	in	in	IN
cord-253501-hkxlq3os	116	13	an	an	DT
cord-253501-hkxlq3os	116	14	immunosuppressed	immunosuppressed	JJ
cord-253501-hkxlq3os	116	15	patient	patient	NN
cord-253501-hkxlq3os	116	16	with	with	IN
cord-253501-hkxlq3os	116	17	chronic	chronic	JJ
cord-253501-hkxlq3os	116	18	HCV	HCV	NNP
cord-253501-hkxlq3os	116	19	and	and	CC
cord-253501-hkxlq3os	116	20	HEV	HEV	NNP
cord-253501-hkxlq3os	116	21	without	without	IN
cord-253501-hkxlq3os	116	22	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	116	23	.	.	.
cord-253501-hkxlq3os	117	1	56	56	CD
cord-253501-hkxlq3os	118	1	Therefore	therefore	RB
cord-253501-hkxlq3os	118	2	,	,	,
cord-253501-hkxlq3os	118	3	usage	usage	NN
cord-253501-hkxlq3os	118	4	of	of	IN
cord-253501-hkxlq3os	118	5	sofosbuvir	sofosbuvir	NN
cord-253501-hkxlq3os	118	6	as	as	IN
cord-253501-hkxlq3os	118	7	an	an	DT
cord-253501-hkxlq3os	118	8	anti	anti	JJ
cord-253501-hkxlq3os	118	9	-	-	JJ
cord-253501-hkxlq3os	118	10	HEV	hev	JJ
cord-253501-hkxlq3os	118	11	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	118	12	needs	need	NNS
cord-253501-hkxlq3os	118	13	further	further	JJ
cord-253501-hkxlq3os	118	14	validation	validation	NN
cord-253501-hkxlq3os	118	15	(	(	-LRB-
cord-253501-hkxlq3os	118	16	discussed	discuss	VBN
cord-253501-hkxlq3os	118	17	further	far	RBR
cord-253501-hkxlq3os	118	18	in	in	IN
cord-253501-hkxlq3os	118	19	the	the	DT
cord-253501-hkxlq3os	118	20	RNA	RNA	NNP
cord-253501-hkxlq3os	118	21	-	-	HYPH
cord-253501-hkxlq3os	118	22	dependent	dependent	JJ
cord-253501-hkxlq3os	118	23	RNA	RNA	NNP
cord-253501-hkxlq3os	118	24	polymerase	polymerase	NN
cord-253501-hkxlq3os	118	25	section	section	NN
cord-253501-hkxlq3os	118	26	of	of	IN
cord-253501-hkxlq3os	118	27	this	this	DT
cord-253501-hkxlq3os	118	28	manuscript	manuscript	NN
cord-253501-hkxlq3os	118	29	)	)	-RRB-
cord-253501-hkxlq3os	118	30	.	.	.
cord-253501-hkxlq3os	119	1	The	the	DT
cord-253501-hkxlq3os	119	2	Zhang	Zhang	NNP
cord-253501-hkxlq3os	119	3	laboratory	laboratory	NN
cord-253501-hkxlq3os	119	4	57	57	CD
cord-253501-hkxlq3os	119	5	developed	develop	VBD
cord-253501-hkxlq3os	119	6	HEV	hev	NN
cord-253501-hkxlq3os	119	7	-	-	HYPH
cord-253501-hkxlq3os	119	8	specific	specific	JJ
cord-253501-hkxlq3os	119	9	PPMOs	ppmo	NNS
cord-253501-hkxlq3os	119	10	and	and	CC
cord-253501-hkxlq3os	119	11	evaluated	evaluate	VBD
cord-253501-hkxlq3os	119	12	their	-PRON-	PRP$
cord-253501-hkxlq3os	119	13	efficacy	efficacy	NN
cord-253501-hkxlq3os	119	14	in	in	IN
cord-253501-hkxlq3os	119	15	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	119	16	viral	viral	JJ
cord-253501-hkxlq3os	119	17	replication	replication	NN
cord-253501-hkxlq3os	119	18	.	.	.
cord-253501-hkxlq3os	120	1	Out	out	IN
cord-253501-hkxlq3os	120	2	of	of	IN
cord-253501-hkxlq3os	120	3	the	the	DT
cord-253501-hkxlq3os	120	4	four	four	CD
cord-253501-hkxlq3os	120	5	PPMOs	ppmo	NNS
cord-253501-hkxlq3os	120	6	tested	test	VBN
cord-253501-hkxlq3os	120	7	,	,	,
cord-253501-hkxlq3os	120	8	PPMO	PPMO	NNP
cord-253501-hkxlq3os	120	9	HP1	HP1	NNP
cord-253501-hkxlq3os	120	10	was	be	VBD
cord-253501-hkxlq3os	120	11	most	most	RBS
cord-253501-hkxlq3os	120	12	effective	effective	JJ
cord-253501-hkxlq3os	120	13	in	in	IN
cord-253501-hkxlq3os	120	14	reducing	reduce	VBG
cord-253501-hkxlq3os	120	15	viral	viral	JJ
cord-253501-hkxlq3os	120	16	replication	replication	NN
cord-253501-hkxlq3os	120	17	in	in	IN
cord-253501-hkxlq3os	120	18	mammalian	mammalian	JJ
cord-253501-hkxlq3os	120	19	cell	cell	NN
cord-253501-hkxlq3os	120	20	culture	culture	NN
cord-253501-hkxlq3os	120	21	.	.	.
cord-253501-hkxlq3os	121	1	57	57	CD
cord-253501-hkxlq3os	122	1	PPMO	PPMO	NNP
cord-253501-hkxlq3os	122	2	HP1	HP1	NNP
cord-253501-hkxlq3os	122	3	specifically	specifically	RB
cord-253501-hkxlq3os	122	4	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	122	5	viral	viral	JJ
cord-253501-hkxlq3os	122	6	translation	translation	NN
cord-253501-hkxlq3os	122	7	by	by	IN
cord-253501-hkxlq3os	122	8	targeting	target	VBG
cord-253501-hkxlq3os	122	9	a	a	DT
cord-253501-hkxlq3os	122	10	highly	highly	RB
cord-253501-hkxlq3os	122	11	conserved	conserve	VBN
cord-253501-hkxlq3os	122	12	sequence	sequence	NN
cord-253501-hkxlq3os	122	13	in	in	IN
cord-253501-hkxlq3os	122	14	the	the	DT
cord-253501-hkxlq3os	122	15	start	start	NN
cord-253501-hkxlq3os	122	16	region	region	NN
cord-253501-hkxlq3os	122	17	of	of	IN
cord-253501-hkxlq3os	122	18	ORF1	ORF1	NNP
cord-253501-hkxlq3os	122	19	of	of	IN
cord-253501-hkxlq3os	122	20	genotype	genotype	NNP
cord-253501-hkxlq3os	122	21	1	1	CD
cord-253501-hkxlq3os	122	22	and	and	CC
cord-253501-hkxlq3os	122	23	genotype	genotype	NN
cord-253501-hkxlq3os	122	24	3	3	CD
cord-253501-hkxlq3os	122	25	HEV	hev	NN
cord-253501-hkxlq3os	122	26	.	.	.
cord-253501-hkxlq3os	123	1	Treatment	treatment	NN
cord-253501-hkxlq3os	123	2	of	of	IN
cord-253501-hkxlq3os	123	3	cells	cell	NNS
cord-253501-hkxlq3os	123	4	with	with	IN
cord-253501-hkxlq3os	123	5	2	2	CD
cord-253501-hkxlq3os	123	6	,	,	,
cord-253501-hkxlq3os	123	7	4	4	CD
cord-253501-hkxlq3os	123	8	and	and	CC
cord-253501-hkxlq3os	123	9	8	8	CD
cord-253501-hkxlq3os	123	10	mM	mm	CD
cord-253501-hkxlq3os	123	11	of	of	IN
cord-253501-hkxlq3os	123	12	PPMO	PPMO	NNP
cord-253501-hkxlq3os	123	13	HP1	HP1	NNP
cord-253501-hkxlq3os	123	14	reduced	reduce	VBD
cord-253501-hkxlq3os	123	15	luciferase	luciferase	JJ
cord-253501-hkxlq3os	123	16	expression	expression	NN
cord-253501-hkxlq3os	123	17	by	by	IN
cord-253501-hkxlq3os	123	18	53.4	53.4	CD
cord-253501-hkxlq3os	123	19	%	%	NN
cord-253501-hkxlq3os	123	20	,	,	,
cord-253501-hkxlq3os	123	21	94.4	94.4	CD
cord-253501-hkxlq3os	123	22	%	%	NN
cord-253501-hkxlq3os	123	23	and	and	CC
cord-253501-hkxlq3os	123	24	99.7	99.7	CD
cord-253501-hkxlq3os	123	25	%	%	NN
cord-253501-hkxlq3os	123	26	,	,	,
cord-253501-hkxlq3os	123	27	respectively	respectively	RB
cord-253501-hkxlq3os	123	28	,	,	,
cord-253501-hkxlq3os	123	29	in	in	IN
cord-253501-hkxlq3os	123	30	a	a	DT
cord-253501-hkxlq3os	123	31	luciferase	luciferase	NN
cord-253501-hkxlq3os	123	32	reporter	reporter	NN
cord-253501-hkxlq3os	123	33	based	base	VBN
cord-253501-hkxlq3os	123	34	HEV	HEV	NNP
cord-253501-hkxlq3os	123	35	replicon	replicon	NN
cord-253501-hkxlq3os	123	36	system	system	NN
cord-253501-hkxlq3os	123	37	.	.	.
cord-253501-hkxlq3os	124	1	57	57	CD
cord-253501-hkxlq3os	125	1	The	the	DT
cord-253501-hkxlq3os	125	2	antiviral	antiviral	JJ
cord-253501-hkxlq3os	125	3	activity	activity	NN
cord-253501-hkxlq3os	125	4	of	of	IN
cord-253501-hkxlq3os	125	5	PPMO	PPMO	NNP
cord-253501-hkxlq3os	125	6	HP1	HP1	NNP
cord-253501-hkxlq3os	125	7	was	be	VBD
cord-253501-hkxlq3os	125	8	specific	specific	JJ
cord-253501-hkxlq3os	125	9	,	,	,
cord-253501-hkxlq3os	125	10	dose	dose	NN
cord-253501-hkxlq3os	125	11	-	-	HYPH
cord-253501-hkxlq3os	125	12	responsive	responsive	JJ
cord-253501-hkxlq3os	125	13	and	and	CC
cord-253501-hkxlq3os	125	14	potent	potent	JJ
cord-253501-hkxlq3os	125	15	.	.	.
cord-253501-hkxlq3os	126	1	Hence	hence	RB
cord-253501-hkxlq3os	126	2	,	,	,
cord-253501-hkxlq3os	126	3	its	-PRON-	PRP$
cord-253501-hkxlq3os	126	4	further	further	JJ
cord-253501-hkxlq3os	126	5	validation	validation	NN
cord-253501-hkxlq3os	126	6	as	as	IN
cord-253501-hkxlq3os	126	7	a	a	DT
cord-253501-hkxlq3os	126	8	potential	potential	JJ
cord-253501-hkxlq3os	126	9	HEV	hev	NN
cord-253501-hkxlq3os	126	10	-	-	HYPH
cord-253501-hkxlq3os	126	11	specific	specific	JJ
cord-253501-hkxlq3os	126	12	antiviral	antiviral	JJ
cord-253501-hkxlq3os	126	13	is	be	VBZ
cord-253501-hkxlq3os	126	14	warranted	warrant	VBN
cord-253501-hkxlq3os	126	15	.	.	.
cord-253501-hkxlq3os	127	1	66E2	66e2	CD
cord-253501-hkxlq3os	127	2	has	have	VBZ
cord-253501-hkxlq3os	127	3	been	be	VBN
cord-253501-hkxlq3os	127	4	identified	identify	VBN
cord-253501-hkxlq3os	127	5	as	as	IN
cord-253501-hkxlq3os	127	6	an	an	DT
cord-253501-hkxlq3os	127	7	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	127	8	of	of	IN
cord-253501-hkxlq3os	127	9	HEV	HEV	NNP
cord-253501-hkxlq3os	127	10	replication	replication	NN
cord-253501-hkxlq3os	127	11	in	in	IN
cord-253501-hkxlq3os	127	12	hepatocytes	hepatocyte	NNS
cord-253501-hkxlq3os	127	13	.	.	.
cord-253501-hkxlq3os	128	1	58	58	CD
cord-253501-hkxlq3os	129	1	66E2	66e2	CD
cord-253501-hkxlq3os	129	2	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	129	3	genotype	genotype	NN
cord-253501-hkxlq3os	129	4	3	3	CD
cord-253501-hkxlq3os	129	5	HEV	hev	NN
cord-253501-hkxlq3os	129	6	replication	replication	NN
cord-253501-hkxlq3os	129	7	by	by	IN
cord-253501-hkxlq3os	129	8	;	;	:
cord-253501-hkxlq3os	129	9	50	50	CD
cord-253501-hkxlq3os	129	10	%	%	NN
cord-253501-hkxlq3os	129	11	,	,	,
cord-253501-hkxlq3os	129	12	without	without	IN
cord-253501-hkxlq3os	129	13	producing	produce	VBG
cord-253501-hkxlq3os	129	14	any	any	DT
cord-253501-hkxlq3os	129	15	detectable	detectable	JJ
cord-253501-hkxlq3os	129	16	cytotoxicity	cytotoxicity	NN
cord-253501-hkxlq3os	129	17	.	.	.
cord-253501-hkxlq3os	130	1	Interestingly	interestingly	RB
cord-253501-hkxlq3os	130	2	,	,	,
cord-253501-hkxlq3os	130	3	66E2	66e2	CD
cord-253501-hkxlq3os	130	4	also	also	RB
cord-253501-hkxlq3os	130	5	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	130	6	HCV	HCV	NNP
cord-253501-hkxlq3os	130	7	and	and	CC
cord-253501-hkxlq3os	130	8	Dengue	Dengue	NNP
cord-253501-hkxlq3os	130	9	virus	virus	NN
cord-253501-hkxlq3os	130	10	replication	replication	NN
cord-253501-hkxlq3os	130	11	.	.	.
cord-253501-hkxlq3os	131	1	58	58	CD
cord-253501-hkxlq3os	132	1	The	the	DT
cord-253501-hkxlq3os	132	2	mechanism	mechanism	NN
cord-253501-hkxlq3os	132	3	by	by	IN
cord-253501-hkxlq3os	132	4	which	which	WDT
cord-253501-hkxlq3os	132	5	66E2	66e2	CD
cord-253501-hkxlq3os	132	6	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	132	7	viral	viral	JJ
cord-253501-hkxlq3os	132	8	replication	replication	NN
cord-253501-hkxlq3os	132	9	remains	remain	VBZ
cord-253501-hkxlq3os	132	10	to	to	TO
cord-253501-hkxlq3os	132	11	be	be	VB
cord-253501-hkxlq3os	132	12	explored	explore	VBN
cord-253501-hkxlq3os	132	13	.	.	.
cord-253501-hkxlq3os	133	1	Mg132	Mg132	NNP
cord-253501-hkxlq3os	133	2	is	be	VBZ
cord-253501-hkxlq3os	133	3	a	a	DT
cord-253501-hkxlq3os	133	4	cell	cell	NN
cord-253501-hkxlq3os	133	5	permeable	permeable	JJ
cord-253501-hkxlq3os	133	6	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	133	7	of	of	IN
cord-253501-hkxlq3os	133	8	the	the	DT
cord-253501-hkxlq3os	133	9	host	host	NN
cord-253501-hkxlq3os	133	10	26S	26S	NNP
cord-253501-hkxlq3os	133	11	proteasome	proteasome	NN
cord-253501-hkxlq3os	133	12	complex	complex	NN
cord-253501-hkxlq3os	133	13	,	,	,
cord-253501-hkxlq3os	133	14	which	which	WDT
cord-253501-hkxlq3os	133	15	is	be	VBZ
cord-253501-hkxlq3os	133	16	responsible	responsible	JJ
cord-253501-hkxlq3os	133	17	for	for	IN
cord-253501-hkxlq3os	133	18	degradation	degradation	NN
cord-253501-hkxlq3os	133	19	of	of	IN
cord-253501-hkxlq3os	133	20	ubiquitinated	ubiquitinated	JJ
cord-253501-hkxlq3os	133	21	proteins	protein	NNS
cord-253501-hkxlq3os	133	22	.	.	.
cord-253501-hkxlq3os	134	1	It	-PRON-	PRP
cord-253501-hkxlq3os	134	2	also	also	RB
cord-253501-hkxlq3os	134	3	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	134	4	serine	serine	NN
cord-253501-hkxlq3os	134	5	and	and	CC
cord-253501-hkxlq3os	134	6	cysteine	cysteine	NN
cord-253501-hkxlq3os	134	7	proteases	protease	NNS
cord-253501-hkxlq3os	134	8	with	with	IN
cord-253501-hkxlq3os	134	9	lower	low	JJR
cord-253501-hkxlq3os	134	10	efficiency	efficiency	NN
cord-253501-hkxlq3os	134	11	.	.	.
cord-253501-hkxlq3os	135	1	It	-PRON-	PRP
cord-253501-hkxlq3os	135	2	is	be	VBZ
cord-253501-hkxlq3os	135	3	also	also	RB
cord-253501-hkxlq3os	135	4	known	know	VBN
cord-253501-hkxlq3os	135	5	to	to	TO
cord-253501-hkxlq3os	135	6	induce	induce	VB
cord-253501-hkxlq3os	135	7	c	c	CD
cord-253501-hkxlq3os	135	8	-	-	:
cord-253501-hkxlq3os	135	9	Jun	Jun	NNP
cord-253501-hkxlq3os	135	10	N	N	NNP
cord-253501-hkxlq3os	135	11	-	-	HYPH
cord-253501-hkxlq3os	135	12	terminal	terminal	JJ
cord-253501-hkxlq3os	135	13	kinase	kinase	NN
cord-253501-hkxlq3os	135	14	-	-	HYPH
cord-253501-hkxlq3os	135	15	dependent	dependent	JJ
cord-253501-hkxlq3os	135	16	apoptosis	apoptosis	NN
cord-253501-hkxlq3os	135	17	,	,	,
cord-253501-hkxlq3os	135	18	to	to	TO
cord-253501-hkxlq3os	135	19	inhibit	inhibit	VB
cord-253501-hkxlq3os	135	20	NFkB	nfkb	JJ
cord-253501-hkxlq3os	135	21	activity	activity	NN
cord-253501-hkxlq3os	135	22	and	and	CC
cord-253501-hkxlq3os	135	23	to	to	TO
cord-253501-hkxlq3os	135	24	block	block	VB
cord-253501-hkxlq3os	135	25	b	b	NNP
cord-253501-hkxlq3os	135	26	-	-	HYPH
cord-253501-hkxlq3os	135	27	secretase	secretase	NN
cord-253501-hkxlq3os	135	28	cleavage	cleavage	NN
cord-253501-hkxlq3os	135	29	.	.	.
cord-253501-hkxlq3os	136	1	59	59	CD
cord-253501-hkxlq3os	136	2	Karpe	Karpe	NNPS
cord-253501-hkxlq3os	136	3	et	et	NNP
cord-253501-hkxlq3os	136	4	al	al	NNP
cord-253501-hkxlq3os	136	5	.	.	.
cord-253501-hkxlq3os	137	1	60	60	CD
cord-253501-hkxlq3os	137	2	reported	report	VBD
cord-253501-hkxlq3os	137	3	significant	significant	JJ
cord-253501-hkxlq3os	137	4	inhibition	inhibition	NN
cord-253501-hkxlq3os	137	5	of	of	IN
cord-253501-hkxlq3os	137	6	HEV	HEV	NNP
cord-253501-hkxlq3os	137	7	replication	replication	NN
cord-253501-hkxlq3os	137	8	-	-	HYPH
cord-253501-hkxlq3os	137	9	related	relate	VBN
cord-253501-hkxlq3os	137	10	luciferase	luciferase	NN
cord-253501-hkxlq3os	137	11	activity	activity	NN
cord-253501-hkxlq3os	137	12	in	in	IN
cord-253501-hkxlq3os	137	13	cells	cell	NNS
cord-253501-hkxlq3os	137	14	treated	treat	VBN
cord-253501-hkxlq3os	137	15	with	with	IN
cord-253501-hkxlq3os	137	16	MG132	mg132	NN
cord-253501-hkxlq3os	137	17	.	.	.
cord-253501-hkxlq3os	138	1	However	however	RB
cord-253501-hkxlq3os	138	2	,	,	,
cord-253501-hkxlq3os	138	3	it	-PRON-	PRP
cord-253501-hkxlq3os	138	4	was	be	VBD
cord-253501-hkxlq3os	138	5	subsequently	subsequently	RB
cord-253501-hkxlq3os	138	6	shown	show	VBN
cord-253501-hkxlq3os	138	7	that	that	IN
cord-253501-hkxlq3os	138	8	312	312	CD
cord-253501-hkxlq3os	138	9	Journal	Journal	NNP
cord-253501-hkxlq3os	138	10	of	of	IN
cord-253501-hkxlq3os	138	11	Clinical	Clinical	NNP
cord-253501-hkxlq3os	138	12	and	and	CC
cord-253501-hkxlq3os	138	13	Translational	Translational	NNP
cord-253501-hkxlq3os	138	14	Hepatology	Hepatology	NNP
cord-253501-hkxlq3os	138	15	2018	2018	CD
cord-253501-hkxlq3os	138	16	vol	vol	NN
cord-253501-hkxlq3os	138	17	.	.	.
cord-253501-hkxlq3os	139	1	6	6	CD
cord-253501-hkxlq3os	139	2	|	|	CD
cord-253501-hkxlq3os	139	3	310	310	CD
cord-253501-hkxlq3os	139	4	-	-	SYM
cord-253501-hkxlq3os	139	5	316	316	CD
cord-253501-hkxlq3os	139	6	MG132	MG132	NNP
cord-253501-hkxlq3os	139	7	also	also	RB
cord-253501-hkxlq3os	139	8	reduced	reduce	VBD
cord-253501-hkxlq3os	139	9	the	the	DT
cord-253501-hkxlq3os	139	10	cellular	cellular	JJ
cord-253501-hkxlq3os	139	11	RNA	RNA	NNP
cord-253501-hkxlq3os	139	12	and	and	CC
cord-253501-hkxlq3os	139	13	protein	protein	NN
cord-253501-hkxlq3os	139	14	levels	level	NNS
cord-253501-hkxlq3os	139	15	,	,	,
cord-253501-hkxlq3os	139	16	indicating	indicate	VBG
cord-253501-hkxlq3os	139	17	its	-PRON-	PRP$
cord-253501-hkxlq3os	139	18	effect	effect	NN
cord-253501-hkxlq3os	139	19	to	to	TO
cord-253501-hkxlq3os	139	20	be	be	VB
cord-253501-hkxlq3os	139	21	nonspecific	nonspecific	JJ
cord-253501-hkxlq3os	139	22	.	.	.
cord-253501-hkxlq3os	140	1	61	61	CD
cord-253501-hkxlq3os	140	2	Zinc	zinc	NN
cord-253501-hkxlq3os	140	3	A	a	DT
cord-253501-hkxlq3os	140	4	recent	recent	JJ
cord-253501-hkxlq3os	140	5	report	report	NN
cord-253501-hkxlq3os	140	6	by	by	IN
cord-253501-hkxlq3os	140	7	Kaushik	Kaushik	NNP
cord-253501-hkxlq3os	140	8	et	et	NNP
cord-253501-hkxlq3os	140	9	al	al	NNP
cord-253501-hkxlq3os	140	10	.	.	.
cord-253501-hkxlq3os	141	1	62	62	CD
cord-253501-hkxlq3os	141	2	has	have	VBZ
cord-253501-hkxlq3os	141	3	demonstrated	demonstrate	VBN
cord-253501-hkxlq3os	141	4	the	the	DT
cord-253501-hkxlq3os	141	5	antiviral	antiviral	JJ
cord-253501-hkxlq3os	141	6	activity	activity	NN
cord-253501-hkxlq3os	141	7	of	of	IN
cord-253501-hkxlq3os	141	8	zinc	zinc	NN
cord-253501-hkxlq3os	141	9	against	against	IN
cord-253501-hkxlq3os	141	10	HEV	HEV	NNP
cord-253501-hkxlq3os	141	11	.	.	.
cord-253501-hkxlq3os	142	1	Zinc	zinc	NN
cord-253501-hkxlq3os	142	2	is	be	VBZ
cord-253501-hkxlq3os	142	3	an	an	DT
cord-253501-hkxlq3os	142	4	essential	essential	JJ
cord-253501-hkxlq3os	142	5	micronutrient	micronutrient	NN
cord-253501-hkxlq3os	142	6	,	,	,
cord-253501-hkxlq3os	142	7	which	which	WDT
cord-253501-hkxlq3os	142	8	plays	play	VBZ
cord-253501-hkxlq3os	142	9	a	a	DT
cord-253501-hkxlq3os	142	10	crucial	crucial	JJ
cord-253501-hkxlq3os	142	11	role	role	NN
cord-253501-hkxlq3os	142	12	in	in	IN
cord-253501-hkxlq3os	142	13	multiple	multiple	JJ
cord-253501-hkxlq3os	142	14	cellular	cellular	JJ
cord-253501-hkxlq3os	142	15	processes	process	NNS
cord-253501-hkxlq3os	142	16	.	.	.
cord-253501-hkxlq3os	143	1	It	-PRON-	PRP
cord-253501-hkxlq3os	143	2	also	also	RB
cord-253501-hkxlq3os	143	3	acts	act	VBZ
cord-253501-hkxlq3os	143	4	as	as	IN
cord-253501-hkxlq3os	143	5	a	a	DT
cord-253501-hkxlq3os	143	6	broad	broad	JJ
cord-253501-hkxlq3os	143	7	-	-	HYPH
cord-253501-hkxlq3os	143	8	spectrum	spectrum	NN
cord-253501-hkxlq3os	143	9	antimicrobial	antimicrobial	NN
cord-253501-hkxlq3os	143	10	against	against	IN
cord-253501-hkxlq3os	143	11	several	several	JJ
cord-253501-hkxlq3os	143	12	pathogens	pathogen	NNS
cord-253501-hkxlq3os	143	13	.	.	.
cord-253501-hkxlq3os	144	1	63	63	CD
cord-253501-hkxlq3os	144	2	,	,	,
cord-253501-hkxlq3os	144	3	64	64	CD
cord-253501-hkxlq3os	144	4	Zinc	zinc	NN
cord-253501-hkxlq3os	144	5	salts	salt	NNS
cord-253501-hkxlq3os	144	6	were	be	VBD
cord-253501-hkxlq3os	144	7	shown	show	VBN
cord-253501-hkxlq3os	144	8	to	to	TO
cord-253501-hkxlq3os	144	9	block	block	VB
cord-253501-hkxlq3os	144	10	the	the	DT
cord-253501-hkxlq3os	144	11	replication	replication	NN
cord-253501-hkxlq3os	144	12	of	of	IN
cord-253501-hkxlq3os	144	13	both	both	DT
cord-253501-hkxlq3os	144	14	genotype	genotype	NN
cord-253501-hkxlq3os	144	15	1	1	CD
cord-253501-hkxlq3os	144	16	and	and	CC
cord-253501-hkxlq3os	144	17	genotype	genotype	NN
cord-253501-hkxlq3os	144	18	3	3	CD
cord-253501-hkxlq3os	144	19	HEV	hev	NN
cord-253501-hkxlq3os	144	20	by	by	IN
cord-253501-hkxlq3os	144	21	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	144	22	the	the	DT
cord-253501-hkxlq3os	144	23	activity	activity	NN
cord-253501-hkxlq3os	144	24	of	of	IN
cord-253501-hkxlq3os	144	25	viral	viral	JJ
cord-253501-hkxlq3os	144	26	RNA	RNA	NNP
cord-253501-hkxlq3os	144	27	-	-	HYPH
cord-253501-hkxlq3os	144	28	dependent	dependent	JJ
cord-253501-hkxlq3os	144	29	RNA	RNA	NNP
cord-253501-hkxlq3os	144	30	polymerase	polymerase	NN
cord-253501-hkxlq3os	144	31	in	in	IN
cord-253501-hkxlq3os	144	32	cultured	cultured	JJ
cord-253501-hkxlq3os	144	33	human	human	JJ
cord-253501-hkxlq3os	144	34	hepatoma	hepatoma	NN
cord-253501-hkxlq3os	144	35	cells	cell	NNS
cord-253501-hkxlq3os	144	36	.	.	.
cord-253501-hkxlq3os	145	1	62	62	CD
cord-253501-hkxlq3os	146	1	Further	further	RB
cord-253501-hkxlq3os	146	2	,	,	,
cord-253501-hkxlq3os	146	3	zinc	zinc	NN
cord-253501-hkxlq3os	146	4	salts	salt	NNS
cord-253501-hkxlq3os	146	5	did	do	VBD
cord-253501-hkxlq3os	146	6	not	not	RB
cord-253501-hkxlq3os	146	7	affect	affect	VB
cord-253501-hkxlq3os	146	8	virus	virus	NN
cord-253501-hkxlq3os	146	9	entry	entry	NN
cord-253501-hkxlq3os	146	10	into	into	IN
cord-253501-hkxlq3os	146	11	the	the	DT
cord-253501-hkxlq3os	146	12	host	host	NN
cord-253501-hkxlq3os	146	13	cell	cell	NN
cord-253501-hkxlq3os	146	14	.	.	.
cord-253501-hkxlq3os	147	1	Zinc	zinc	NN
cord-253501-hkxlq3os	147	2	also	also	RB
cord-253501-hkxlq3os	147	3	displayed	display	VBD
cord-253501-hkxlq3os	147	4	moderate	moderate	JJ
cord-253501-hkxlq3os	147	5	cooperativity	cooperativity	NN
cord-253501-hkxlq3os	147	6	with	with	IN
cord-253501-hkxlq3os	147	7	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	147	8	in	in	IN
cord-253501-hkxlq3os	147	9	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	147	10	viral	viral	JJ
cord-253501-hkxlq3os	147	11	replication	replication	NN
cord-253501-hkxlq3os	147	12	.	.	.
cord-253501-hkxlq3os	148	1	These	these	DT
cord-253501-hkxlq3os	148	2	data	datum	NNS
cord-253501-hkxlq3os	148	3	indicate	indicate	VBP
cord-253501-hkxlq3os	148	4	the	the	DT
cord-253501-hkxlq3os	148	5	possible	possible	JJ
cord-253501-hkxlq3os	148	6	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	148	7	usage	usage	NN
cord-253501-hkxlq3os	148	8	of	of	IN
cord-253501-hkxlq3os	148	9	zinc	zinc	NN
cord-253501-hkxlq3os	148	10	in	in	IN
cord-253501-hkxlq3os	148	11	controlling	control	VBG
cord-253501-hkxlq3os	148	12	HEV	HEV	NNP
cord-253501-hkxlq3os	148	13	infection	infection	NN
cord-253501-hkxlq3os	148	14	.	.	.
cord-253501-hkxlq3os	149	1	However	however	RB
cord-253501-hkxlq3os	149	2	,	,	,
cord-253501-hkxlq3os	149	3	considering	consider	VBG
cord-253501-hkxlq3os	149	4	the	the	DT
cord-253501-hkxlq3os	149	5	complexities	complexity	NNS
cord-253501-hkxlq3os	149	6	involved	involve	VBN
cord-253501-hkxlq3os	149	7	in	in	IN
cord-253501-hkxlq3os	149	8	serum	serum	NN
cord-253501-hkxlq3os	149	9	/	/	SYM
cord-253501-hkxlq3os	149	10	plasma	plasma	NN
cord-253501-hkxlq3os	149	11	and	and	CC
cord-253501-hkxlq3os	149	12	intracellular	intracellular	JJ
cord-253501-hkxlq3os	149	13	zinc	zinc	NN
cord-253501-hkxlq3os	149	14	homeostasis	homeostasis	NN
cord-253501-hkxlq3os	149	15	,	,	,
cord-253501-hkxlq3os	149	16	65	65	CD
cord-253501-hkxlq3os	149	17	the	the	DT
cord-253501-hkxlq3os	149	18	efficacy	efficacy	NN
cord-253501-hkxlq3os	149	19	of	of	IN
cord-253501-hkxlq3os	149	20	zinc	zinc	NN
cord-253501-hkxlq3os	149	21	in	in	IN
cord-253501-hkxlq3os	149	22	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	149	23	HEV	HEV	NNP
cord-253501-hkxlq3os	149	24	replication	replication	NN
cord-253501-hkxlq3os	149	25	in	in	IN
cord-253501-hkxlq3os	149	26	vivo	vivo	NN
cord-253501-hkxlq3os	149	27	remains	remain	VBZ
cord-253501-hkxlq3os	149	28	to	to	TO
cord-253501-hkxlq3os	149	29	be	be	VB
cord-253501-hkxlq3os	149	30	evaluated	evaluate	VBN
cord-253501-hkxlq3os	149	31	.	.	.
cord-253501-hkxlq3os	150	1	Moreover	moreover	RB
cord-253501-hkxlq3os	150	2	,	,	,
cord-253501-hkxlq3os	150	3	the	the	DT
cord-253501-hkxlq3os	150	4	detailed	detailed	JJ
cord-253501-hkxlq3os	150	5	mechanism(s	mechanism(s	NNP
cord-253501-hkxlq3os	150	6	)	)	-RRB-
cord-253501-hkxlq3os	150	7	underlying	underlie	VBG
cord-253501-hkxlq3os	150	8	the	the	DT
cord-253501-hkxlq3os	150	9	inhibitory	inhibitory	JJ
cord-253501-hkxlq3os	150	10	action	action	NN
cord-253501-hkxlq3os	150	11	of	of	IN
cord-253501-hkxlq3os	150	12	zinc	zinc	NN
cord-253501-hkxlq3os	150	13	on	on	IN
cord-253501-hkxlq3os	150	14	HEV	hev	NN
cord-253501-hkxlq3os	150	15	replication	replication	NN
cord-253501-hkxlq3os	150	16	needs	need	VBZ
cord-253501-hkxlq3os	150	17	to	to	TO
cord-253501-hkxlq3os	150	18	be	be	VB
cord-253501-hkxlq3os	150	19	investigated	investigate	VBN
cord-253501-hkxlq3os	150	20	.	.	.
cord-253501-hkxlq3os	151	1	The	the	DT
cord-253501-hkxlq3os	151	2	following	follow	VBG
cord-253501-hkxlq3os	151	3	stages	stage	NNS
cord-253501-hkxlq3os	151	4	of	of	IN
cord-253501-hkxlq3os	151	5	the	the	DT
cord-253501-hkxlq3os	151	6	HEV	HEV	NNP
cord-253501-hkxlq3os	151	7	life	life	NN
cord-253501-hkxlq3os	151	8	cycle	cycle	NN
cord-253501-hkxlq3os	151	9	are	be	VBP
cord-253501-hkxlq3os	151	10	potential	potential	JJ
cord-253501-hkxlq3os	151	11	targets	target	NNS
cord-253501-hkxlq3os	151	12	for	for	IN
cord-253501-hkxlq3os	151	13	the	the	DT
cord-253501-hkxlq3os	151	14	development	development	NN
cord-253501-hkxlq3os	151	15	of	of	IN
cord-253501-hkxlq3os	151	16	specific	specific	JJ
cord-253501-hkxlq3os	151	17	antivirals	antiviral	NNS
cord-253501-hkxlq3os	151	18	(	(	-LRB-
cord-253501-hkxlq3os	151	19	Fig	fig	NN
cord-253501-hkxlq3os	151	20	.	.	.
cord-253501-hkxlq3os	151	21	1	1	CD
cord-253501-hkxlq3os	151	22	)	)	-RRB-
cord-253501-hkxlq3os	151	23	.	.	.
cord-253501-hkxlq3os	152	1	The	the	DT
cord-253501-hkxlq3os	152	2	specific	specific	JJ
cord-253501-hkxlq3os	152	3	receptor	receptor	NN
cord-253501-hkxlq3os	152	4	by	by	IN
cord-253501-hkxlq3os	152	5	which	which	WDT
cord-253501-hkxlq3os	152	6	HEV	HEV	NNP
cord-253501-hkxlq3os	152	7	enters	enter	VBZ
cord-253501-hkxlq3os	152	8	the	the	DT
cord-253501-hkxlq3os	152	9	host	host	NN
cord-253501-hkxlq3os	152	10	cell	cell	NN
cord-253501-hkxlq3os	152	11	is	be	VBZ
cord-253501-hkxlq3os	152	12	unknown	unknown	JJ
cord-253501-hkxlq3os	152	13	.	.	.
cord-253501-hkxlq3os	153	1	However	however	RB
cord-253501-hkxlq3os	153	2	,	,	,
cord-253501-hkxlq3os	153	3	it	-PRON-	PRP
cord-253501-hkxlq3os	153	4	has	have	VBZ
cord-253501-hkxlq3os	153	5	been	be	VBN
cord-253501-hkxlq3os	153	6	demonstrated	demonstrate	VBN
cord-253501-hkxlq3os	153	7	that	that	IN
cord-253501-hkxlq3os	153	8	heparin	heparin	NN
cord-253501-hkxlq3os	153	9	sulfate	sulfate	NN
cord-253501-hkxlq3os	153	10	proteoglycans	proteoglycan	NNS
cord-253501-hkxlq3os	153	11	may	may	MD
cord-253501-hkxlq3os	153	12	serve	serve	VB
cord-253501-hkxlq3os	153	13	as	as	IN
cord-253501-hkxlq3os	153	14	attachment	attachment	NN
cord-253501-hkxlq3os	153	15	receptors	receptor	NNS
cord-253501-hkxlq3os	153	16	to	to	TO
cord-253501-hkxlq3os	153	17	facilitate	facilitate	VB
cord-253501-hkxlq3os	153	18	HEV	HEV	NNP
cord-253501-hkxlq3os	153	19	entry	entry	NN
cord-253501-hkxlq3os	153	20	into	into	IN
cord-253501-hkxlq3os	153	21	the	the	DT
cord-253501-hkxlq3os	153	22	host	host	NN
cord-253501-hkxlq3os	153	23	cells	cell	NNS
cord-253501-hkxlq3os	153	24	.	.	.
cord-253501-hkxlq3os	154	1	66	66	CD
cord-253501-hkxlq3os	155	1	The	the	DT
cord-253501-hkxlq3os	155	2	HEV	HEV	NNP
cord-253501-hkxlq3os	155	3	capsid	capsid	NN
cord-253501-hkxlq3os	155	4	protein	protein	NN
cord-253501-hkxlq3os	155	5	ORF2	ORF2	NNP
cord-253501-hkxlq3os	155	6	also	also	RB
cord-253501-hkxlq3os	155	7	interacts	interact	VBZ
cord-253501-hkxlq3os	155	8	with	with	IN
cord-253501-hkxlq3os	155	9	heat	heat	NN
cord-253501-hkxlq3os	155	10	shock	shock	NN
cord-253501-hkxlq3os	155	11	protein	protein	NN
cord-253501-hkxlq3os	155	12	90	90	CD
cord-253501-hkxlq3os	155	13	and	and	CC
cord-253501-hkxlq3os	155	14	glucoseregulated	glucoseregulate	VBD
cord-253501-hkxlq3os	155	15	protein	protein	NN
cord-253501-hkxlq3os	155	16	78	78	CD
cord-253501-hkxlq3os	155	17	(	(	-LRB-
cord-253501-hkxlq3os	155	18	Grp78	Grp78	NNP
cord-253501-hkxlq3os	155	19	)	)	-RRB-
cord-253501-hkxlq3os	155	20	.	.	.
cord-253501-hkxlq3os	156	1	Grp78	Grp78	NNP
cord-253501-hkxlq3os	156	2	or	or	CC
cord-253501-hkxlq3os	156	3	heat	heat	NN
cord-253501-hkxlq3os	156	4	shock	shock	NN
cord-253501-hkxlq3os	156	5	protein	protein	NN
cord-253501-hkxlq3os	156	6	90	90	CD
cord-253501-hkxlq3os	156	7	may	may	MD
cord-253501-hkxlq3os	156	8	be	be	VB
cord-253501-hkxlq3os	156	9	involved	involve	VBN
cord-253501-hkxlq3os	156	10	in	in	IN
cord-253501-hkxlq3os	156	11	the	the	DT
cord-253501-hkxlq3os	156	12	intracellular	intracellular	JJ
cord-253501-hkxlq3os	156	13	transport	transport	NN
cord-253501-hkxlq3os	156	14	of	of	IN
cord-253501-hkxlq3os	156	15	the	the	DT
cord-253501-hkxlq3os	156	16	virus	virus	NN
cord-253501-hkxlq3os	156	17	.	.	.
cord-253501-hkxlq3os	157	1	67	67	CD
cord-253501-hkxlq3os	157	2	,	,	,
cord-253501-hkxlq3os	157	3	68	68	CD
cord-253501-hkxlq3os	157	4	Grp78	Grp78	NNP
cord-253501-hkxlq3os	157	5	has	have	VBZ
cord-253501-hkxlq3os	157	6	also	also	RB
cord-253501-hkxlq3os	157	7	been	be	VBN
cord-253501-hkxlq3os	157	8	shown	show	VBN
cord-253501-hkxlq3os	157	9	to	to	TO
cord-253501-hkxlq3os	157	10	interact	interact	VB
cord-253501-hkxlq3os	157	11	with	with	IN
cord-253501-hkxlq3os	157	12	the	the	DT
cord-253501-hkxlq3os	157	13	envelope	envelope	NN
cord-253501-hkxlq3os	157	14	protein	protein	NN
cord-253501-hkxlq3os	157	15	of	of	IN
cord-253501-hkxlq3os	157	16	the	the	DT
cord-253501-hkxlq3os	157	17	Japanese	japanese	JJ
cord-253501-hkxlq3os	157	18	encephalitis	encephalitis	JJ
cord-253501-hkxlq3os	157	19	virus	virus	NN
cord-253501-hkxlq3os	157	20	,	,	,
cord-253501-hkxlq3os	157	21	facilitating	facilitate	VBG
cord-253501-hkxlq3os	157	22	its	-PRON-	PRP$
cord-253501-hkxlq3os	157	23	entry	entry	NN
cord-253501-hkxlq3os	157	24	into	into	IN
cord-253501-hkxlq3os	157	25	the	the	DT
cord-253501-hkxlq3os	157	26	host	host	NN
cord-253501-hkxlq3os	157	27	cells	cell	NNS
cord-253501-hkxlq3os	157	28	.	.	.
cord-253501-hkxlq3os	158	1	69	69	CD
cord-253501-hkxlq3os	159	1	It	-PRON-	PRP
cord-253501-hkxlq3os	159	2	remains	remain	VBZ
cord-253501-hkxlq3os	159	3	to	to	TO
cord-253501-hkxlq3os	159	4	be	be	VB
cord-253501-hkxlq3os	159	5	tested	test	VBN
cord-253501-hkxlq3os	159	6	whether	whether	IN
cord-253501-hkxlq3os	159	7	Grp78	Grp78	NNP
cord-253501-hkxlq3os	159	8	and	and	CC
cord-253501-hkxlq3os	159	9	ORF2	ORF2	NNP
cord-253501-hkxlq3os	159	10	interaction	interaction	NN
cord-253501-hkxlq3os	159	11	mediates	mediate	VBZ
cord-253501-hkxlq3os	159	12	HEV	HEV	NNP
cord-253501-hkxlq3os	159	13	entry	entry	NN
cord-253501-hkxlq3os	159	14	.	.	.
cord-253501-hkxlq3os	160	1	Inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	160	2	of	of	IN
cord-253501-hkxlq3os	160	3	receptor	receptor	NN
cord-253501-hkxlq3os	160	4	binding	binding	NN
cord-253501-hkxlq3os	160	5	or	or	CC
cord-253501-hkxlq3os	160	6	intracellular	intracellular	JJ
cord-253501-hkxlq3os	160	7	transport	transport	NN
cord-253501-hkxlq3os	160	8	of	of	IN
cord-253501-hkxlq3os	160	9	the	the	DT
cord-253501-hkxlq3os	160	10	virus	virus	NN
cord-253501-hkxlq3os	160	11	are	be	VBP
cord-253501-hkxlq3os	160	12	supposed	suppose	VBN
cord-253501-hkxlq3os	160	13	to	to	TO
cord-253501-hkxlq3os	160	14	block	block	VB
cord-253501-hkxlq3os	160	15	viral	viral	JJ
cord-253501-hkxlq3os	160	16	life	life	NN
cord-253501-hkxlq3os	160	17	cycle	cycle	NN
cord-253501-hkxlq3os	160	18	at	at	IN
cord-253501-hkxlq3os	160	19	a	a	DT
cord-253501-hkxlq3os	160	20	very	very	RB
cord-253501-hkxlq3os	160	21	early	early	JJ
cord-253501-hkxlq3os	160	22	stage	stage	NN
cord-253501-hkxlq3os	160	23	.	.	.
cord-253501-hkxlq3os	161	1	Among	among	IN
cord-253501-hkxlq3os	161	2	the	the	DT
cord-253501-hkxlq3os	161	3	nonstructural	nonstructural	JJ
cord-253501-hkxlq3os	161	4	proteins	protein	NNS
cord-253501-hkxlq3os	161	5	encoded	encode	VBN
cord-253501-hkxlq3os	161	6	by	by	IN
cord-253501-hkxlq3os	161	7	the	the	DT
cord-253501-hkxlq3os	161	8	HEV	HEV	NNP
cord-253501-hkxlq3os	161	9	ORF1	ORF1	NNP
cord-253501-hkxlq3os	161	10	,	,	,
cord-253501-hkxlq3os	161	11	methyltransferase	methyltransferase	NN
cord-253501-hkxlq3os	161	12	is	be	VBZ
cord-253501-hkxlq3os	161	13	responsible	responsible	JJ
cord-253501-hkxlq3os	161	14	for	for	IN
cord-253501-hkxlq3os	161	15	capping	cap	VBG
cord-253501-hkxlq3os	161	16	of	of	IN
cord-253501-hkxlq3os	161	17	the	the	DT
cord-253501-hkxlq3os	161	18	viral	viral	JJ
cord-253501-hkxlq3os	161	19	genome	genome	NN
cord-253501-hkxlq3os	161	20	.	.	.
cord-253501-hkxlq3os	162	1	70	70	CD
cord-253501-hkxlq3os	162	2	Addition	addition	NN
cord-253501-hkxlq3os	162	3	of	of	IN
cord-253501-hkxlq3os	162	4	a	a	DT
cord-253501-hkxlq3os	162	5	7-methylguanosine	7-methylguanosine	CD
cord-253501-hkxlq3os	162	6	cap	cap	NN
cord-253501-hkxlq3os	162	7	at	at	IN
cord-253501-hkxlq3os	162	8	the	the	DT
cord-253501-hkxlq3os	162	9	5′terminus	5′terminus	CD
cord-253501-hkxlq3os	162	10	of	of	IN
cord-253501-hkxlq3os	162	11	the	the	DT
cord-253501-hkxlq3os	162	12	viral	viral	JJ
cord-253501-hkxlq3os	162	13	genome	genome	NN
cord-253501-hkxlq3os	162	14	confers	confer	VBZ
cord-253501-hkxlq3os	162	15	stability	stability	NN
cord-253501-hkxlq3os	162	16	and	and	CC
cord-253501-hkxlq3os	162	17	protects	protect	VBZ
cord-253501-hkxlq3os	162	18	the	the	DT
cord-253501-hkxlq3os	162	19	viral	viral	JJ
cord-253501-hkxlq3os	162	20	RNA	RNA	NNP
cord-253501-hkxlq3os	162	21	from	from	IN
cord-253501-hkxlq3os	162	22	the	the	DT
cord-253501-hkxlq3os	162	23	host	host	NN
cord-253501-hkxlq3os	162	24	innate	innate	JJ
cord-253501-hkxlq3os	162	25	immune	immune	JJ
cord-253501-hkxlq3os	162	26	effectors	effector	NNS
cord-253501-hkxlq3os	162	27	.	.	.
cord-253501-hkxlq3os	163	1	71	71	CD
cord-253501-hkxlq3os	163	2	Uncapped	uncapped	JJ
cord-253501-hkxlq3os	163	3	HEV	HEV	NNP
cord-253501-hkxlq3os	163	4	RNA	RNA	NNP
cord-253501-hkxlq3os	163	5	is	be	VBZ
cord-253501-hkxlq3os	163	6	inefficient	inefficient	JJ
cord-253501-hkxlq3os	163	7	in	in	IN
cord-253501-hkxlq3os	163	8	replication	replication	NN
cord-253501-hkxlq3os	163	9	.	.	.
cord-253501-hkxlq3os	164	1	72	72	CD
cord-253501-hkxlq3os	165	1	Moreover	moreover	RB
cord-253501-hkxlq3os	165	2	,	,	,
cord-253501-hkxlq3os	165	3	in	in	IN
cord-253501-hkxlq3os	165	4	contrast	contrast	NN
cord-253501-hkxlq3os	165	5	to	to	IN
cord-253501-hkxlq3os	165	6	the	the	DT
cord-253501-hkxlq3os	165	7	host	host	NN
cord-253501-hkxlq3os	165	8	methyltransferases	methyltransferases	NNP
cord-253501-hkxlq3os	165	9	wherein	wherein	WRB
cord-253501-hkxlq3os	165	10	guanyltransferase	guanyltransferase	NNP
cord-253501-hkxlq3os	165	11	donates	donate	VBZ
cord-253501-hkxlq3os	165	12	a	a	DT
cord-253501-hkxlq3os	165	13	GMP	GMP	NNP
cord-253501-hkxlq3os	165	14	moiety	moiety	NN
cord-253501-hkxlq3os	165	15	to	to	IN
cord-253501-hkxlq3os	165	16	the	the	DT
cord-253501-hkxlq3os	165	17	RNA	RNA	NNP
cord-253501-hkxlq3os	165	18	,	,	,
cord-253501-hkxlq3os	165	19	followed	follow	VBN
cord-253501-hkxlq3os	165	20	by	by	IN
cord-253501-hkxlq3os	165	21	cap	cap	NN
cord-253501-hkxlq3os	165	22	methylation	methylation	NN
cord-253501-hkxlq3os	165	23	by	by	IN
cord-253501-hkxlq3os	165	24	guanine-7-methyltransferase	guanine-7-methyltransferase	NN
cord-253501-hkxlq3os	165	25	activity	activity	NN
cord-253501-hkxlq3os	165	26	;	;	:
cord-253501-hkxlq3os	165	27	HEV	HEV	NNP
cord-253501-hkxlq3os	165	28	methyltransferase	methyltransferase	NN
cord-253501-hkxlq3os	165	29	follows	follow	VBZ
cord-253501-hkxlq3os	165	30	a	a	DT
cord-253501-hkxlq3os	165	31	reverse	reverse	JJ
cord-253501-hkxlq3os	165	32	order	order	NN
cord-253501-hkxlq3os	165	33	,	,	,
cord-253501-hkxlq3os	165	34	thereby	thereby	RB
cord-253501-hkxlq3os	165	35	restricting	restrict	VBG
cord-253501-hkxlq3os	165	36	its	-PRON-	PRP$
cord-253501-hkxlq3os	165	37	activity	activity	NN
cord-253501-hkxlq3os	165	38	to	to	IN
cord-253501-hkxlq3os	165	39	the	the	DT
cord-253501-hkxlq3os	165	40	viral	viral	JJ
cord-253501-hkxlq3os	165	41	RNA	RNA	NNP
cord-253501-hkxlq3os	165	42	.	.	.
cord-253501-hkxlq3os	166	1	70	70	CD
cord-253501-hkxlq3os	167	1	Therefore	therefore	RB
cord-253501-hkxlq3os	167	2	,	,	,
cord-253501-hkxlq3os	167	3	inhibition	inhibition	NN
cord-253501-hkxlq3os	167	4	of	of	IN
cord-253501-hkxlq3os	167	5	HEV	hev	NN
cord-253501-hkxlq3os	167	6	methyltransferase	methyltransferase	NN
cord-253501-hkxlq3os	167	7	activity	activity	NN
cord-253501-hkxlq3os	167	8	appears	appear	VBZ
cord-253501-hkxlq3os	167	9	to	to	TO
cord-253501-hkxlq3os	167	10	be	be	VB
cord-253501-hkxlq3os	167	11	a	a	DT
cord-253501-hkxlq3os	167	12	potent	potent	JJ
cord-253501-hkxlq3os	167	13	antiviral	antiviral	JJ
cord-253501-hkxlq3os	167	14	strategy	strategy	NN
cord-253501-hkxlq3os	167	15	.	.	.
cord-253501-hkxlq3os	168	1	It	-PRON-	PRP
cord-253501-hkxlq3os	168	2	is	be	VBZ
cord-253501-hkxlq3os	168	3	noteworthy	noteworthy	JJ
cord-253501-hkxlq3os	168	4	that	that	IN
cord-253501-hkxlq3os	168	5	Neplanocin	Neplanocin	NNP
cord-253501-hkxlq3os	168	6	A	A	NNP
cord-253501-hkxlq3os	168	7	and	and	CC
cord-253501-hkxlq3os	168	8	3-deaza	3-deaza	CD
cord-253501-hkxlq3os	168	9	-	-	HYPH
cord-253501-hkxlq3os	168	10	adenosine	adenosine	NN
cord-253501-hkxlq3os	168	11	,	,	,
cord-253501-hkxlq3os	168	12	the	the	DT
cord-253501-hkxlq3os	168	13	two	two	CD
cord-253501-hkxlq3os	168	14	known	know	VBN
cord-253501-hkxlq3os	168	15	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	168	16	of	of	IN
cord-253501-hkxlq3os	168	17	influenza	influenza	NN
cord-253501-hkxlq3os	168	18	virus	virus	NN
cord-253501-hkxlq3os	168	19	methyltransferases	methyltransferase	NNS
cord-253501-hkxlq3os	168	20	,	,	,
cord-253501-hkxlq3os	168	21	interfere	interfere	VB
cord-253501-hkxlq3os	168	22	with	with	IN
cord-253501-hkxlq3os	168	23	virus	virus	NN
cord-253501-hkxlq3os	168	24	replication	replication	NN
cord-253501-hkxlq3os	168	25	.	.	.
cord-253501-hkxlq3os	169	1	73	73	CD
cord-253501-hkxlq3os	170	1	Neplanocin	Neplanocin	NNP
cord-253501-hkxlq3os	170	2	A	A	NNP
cord-253501-hkxlq3os	170	3	is	be	VBZ
cord-253501-hkxlq3os	170	4	also	also	RB
cord-253501-hkxlq3os	170	5	a	a	DT
cord-253501-hkxlq3os	170	6	potent	potent	JJ
cord-253501-hkxlq3os	170	7	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	170	8	of	of	IN
cord-253501-hkxlq3os	170	9	vaccinia	vaccinia	NN
cord-253501-hkxlq3os	170	10	virus	virus	NN
cord-253501-hkxlq3os	170	11	replication	replication	NN
cord-253501-hkxlq3os	170	12	.	.	.
cord-253501-hkxlq3os	171	1	74	74	CD
cord-253501-hkxlq3os	171	2	Inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	171	3	against	against	IN
cord-253501-hkxlq3os	171	4	Dengue	Dengue	NNP
cord-253501-hkxlq3os	171	5	virus	virus	NN
cord-253501-hkxlq3os	171	6	methyltransferases	methyltransferase	NNS
cord-253501-hkxlq3os	171	7	have	have	VBP
cord-253501-hkxlq3os	171	8	also	also	RB
cord-253501-hkxlq3os	171	9	been	be	VBN
cord-253501-hkxlq3os	171	10	screened	screen	VBN
cord-253501-hkxlq3os	171	11	.	.	.
cord-253501-hkxlq3os	172	1	75	75	CD
cord-253501-hkxlq3os	172	2	 	 	_SP
cord-253501-hkxlq3os	172	3	Direct	direct	JJ
cord-253501-hkxlq3os	172	4	-	-	HYPH
cord-253501-hkxlq3os	172	5	acting	act	VBG
cord-253501-hkxlq3os	172	6	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	172	7	of	of	IN
cord-253501-hkxlq3os	172	8	HEV	HEV	NNP
cord-253501-hkxlq3os	172	9	RNA	RNA	NNP
cord-253501-hkxlq3os	172	10	-	-	HYPH
cord-253501-hkxlq3os	172	11	dependent	dependent	JJ
cord-253501-hkxlq3os	172	12	RNA	RNA	NNP
cord-253501-hkxlq3os	172	13	polymerase	polymerase	NN
cord-253501-hkxlq3os	172	14	function	function	NN
cord-253501-hkxlq3os	172	15	:	:	:
cord-253501-hkxlq3os	172	16	RNA	rna	NN
cord-253501-hkxlq3os	172	17	-	-	HYPH
cord-253501-hkxlq3os	172	18	dependent	dependent	JJ
cord-253501-hkxlq3os	172	19	RNA	RNA	NNP
cord-253501-hkxlq3os	172	20	polymerase	polymerase	NN
cord-253501-hkxlq3os	172	21	is	be	VBZ
cord-253501-hkxlq3os	172	22	the	the	DT
cord-253501-hkxlq3os	172	23	most	most	RBS
cord-253501-hkxlq3os	172	24	important	important	JJ
cord-253501-hkxlq3os	172	25	factor	factor	NN
cord-253501-hkxlq3os	172	26	in	in	IN
cord-253501-hkxlq3os	172	27	the	the	DT
cord-253501-hkxlq3os	172	28	life	life	NN
cord-253501-hkxlq3os	172	29	cycle	cycle	NN
cord-253501-hkxlq3os	172	30	of	of	IN
cord-253501-hkxlq3os	172	31	all	all	DT
cord-253501-hkxlq3os	172	32	RNA	RNA	NNP
cord-253501-hkxlq3os	172	33	viruses	virus	NNS
cord-253501-hkxlq3os	172	34	and	and	CC
cord-253501-hkxlq3os	172	35	,	,	,
cord-253501-hkxlq3os	172	36	therefore	therefore	RB
cord-253501-hkxlq3os	172	37	,	,	,
cord-253501-hkxlq3os	172	38	RNA	RNA	NNP
cord-253501-hkxlq3os	172	39	-	-	HYPH
cord-253501-hkxlq3os	172	40	dependent	dependent	JJ
cord-253501-hkxlq3os	172	41	RNA	RNA	NNP
cord-253501-hkxlq3os	172	42	polymerase	polymerase	NN
cord-253501-hkxlq3os	172	43	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	172	44	are	be	VBP
cord-253501-hkxlq3os	172	45	supposed	suppose	VBN
cord-253501-hkxlq3os	172	46	to	to	TO
cord-253501-hkxlq3os	172	47	be	be	VB
cord-253501-hkxlq3os	172	48	potent	potent	JJ
cord-253501-hkxlq3os	172	49	antivirals	antiviral	NNS
cord-253501-hkxlq3os	172	50	.	.	.
cord-253501-hkxlq3os	173	1	One	one	CD
cord-253501-hkxlq3os	173	2	such	such	JJ
cord-253501-hkxlq3os	173	3	antiviral	antiviral	JJ
cord-253501-hkxlq3os	173	4	against	against	IN
cord-253501-hkxlq3os	173	5	HCV	HCV	NNP
cord-253501-hkxlq3os	173	6	is	be	VBZ
cord-253501-hkxlq3os	173	7	sofosbuvir	sofosbuvir	NNP
cord-253501-hkxlq3os	173	8	,	,	,
cord-253501-hkxlq3os	173	9	which	which	WDT
cord-253501-hkxlq3os	173	10	acts	act	VBZ
cord-253501-hkxlq3os	173	11	by	by	IN
cord-253501-hkxlq3os	173	12	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	173	13	the	the	DT
cord-253501-hkxlq3os	173	14	activity	activity	NN
cord-253501-hkxlq3os	173	15	of	of	IN
cord-253501-hkxlq3os	173	16	HCV	HCV	NNP
cord-253501-hkxlq3os	173	17	RNAdependent	RNAdependent	NNP
cord-253501-hkxlq3os	173	18	RNA	RNA	NNP
cord-253501-hkxlq3os	173	19	polymerase	polymerase	NN
cord-253501-hkxlq3os	173	20	.	.	.
cord-253501-hkxlq3os	174	1	76	76	CD
cord-253501-hkxlq3os	175	1	Dao	Dao	NNP
cord-253501-hkxlq3os	175	2	Thi	Thi	NNP
cord-253501-hkxlq3os	175	3	et	et	FW
cord-253501-hkxlq3os	175	4	al	al	NNP
cord-253501-hkxlq3os	175	5	.	.	.
cord-253501-hkxlq3os	176	1	indicated	indicate	VBD
cord-253501-hkxlq3os	176	2	the	the	DT
cord-253501-hkxlq3os	176	3	effectiveness	effectiveness	NN
cord-253501-hkxlq3os	176	4	of	of	IN
cord-253501-hkxlq3os	176	5	sofosbuvir	sofosbuvir	NNP
cord-253501-hkxlq3os	176	6	in	in	IN
cord-253501-hkxlq3os	176	7	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	176	8	HEV	HEV	NNP
cord-253501-hkxlq3os	176	9	replication	replication	NN
cord-253501-hkxlq3os	176	10	;	;	:
cord-253501-hkxlq3os	176	11	however	however	RB
cord-253501-hkxlq3os	176	12	,	,	,
cord-253501-hkxlq3os	176	13	subsequent	subsequent	JJ
cord-253501-hkxlq3os	176	14	studies	study	NNS
cord-253501-hkxlq3os	176	15	failed	fail	VBD
cord-253501-hkxlq3os	176	16	to	to	TO
cord-253501-hkxlq3os	176	17	observe	observe	VB
cord-253501-hkxlq3os	176	18	its	-PRON-	PRP$
cord-253501-hkxlq3os	176	19	potent	potent	JJ
cord-253501-hkxlq3os	176	20	inhibitory	inhibitory	JJ
cord-253501-hkxlq3os	176	21	effect	effect	NN
cord-253501-hkxlq3os	176	22	.	.	.
cord-253501-hkxlq3os	177	1	[	[	-LRB-
cord-253501-hkxlq3os	177	2	54	54	CD
cord-253501-hkxlq3os	177	3	]	]	-RRB-
cord-253501-hkxlq3os	177	4	[	[	-LRB-
cord-253501-hkxlq3os	177	5	55	55	CD
cord-253501-hkxlq3os	177	6	]	]	-RRB-
cord-253501-hkxlq3os	178	1	[	[	-LRB-
cord-253501-hkxlq3os	178	2	56	56	CD
cord-253501-hkxlq3os	178	3	]	]	-RRB-
cord-253501-hkxlq3os	179	1	Nevertheless	nevertheless	RB
cord-253501-hkxlq3os	179	2	,	,	,
cord-253501-hkxlq3os	179	3	optimization	optimization	NN
cord-253501-hkxlq3os	179	4	of	of	IN
cord-253501-hkxlq3os	179	5	the	the	DT
cord-253501-hkxlq3os	179	6	sofosbuvir	sofosbuvir	NNP
cord-253501-hkxlq3os	179	7	structure	structure	NN
cord-253501-hkxlq3os	179	8	that	that	WDT
cord-253501-hkxlq3os	179	9	improves	improve	VBZ
cord-253501-hkxlq3os	179	10	its	-PRON-	PRP$
cord-253501-hkxlq3os	179	11	inhibitory	inhibitory	JJ
cord-253501-hkxlq3os	179	12	effect	effect	NN
cord-253501-hkxlq3os	179	13	on	on	IN
cord-253501-hkxlq3os	179	14	HEV	HEV	NNP
cord-253501-hkxlq3os	179	15	RNA	RNA	NNP
cord-253501-hkxlq3os	179	16	-	-	HYPH
cord-253501-hkxlq3os	179	17	dependent	dependent	JJ
cord-253501-hkxlq3os	179	18	RNA	RNA	NNP
cord-253501-hkxlq3os	179	19	polymerase	polymerase	NN
cord-253501-hkxlq3os	179	20	is	be	VBZ
cord-253501-hkxlq3os	179	21	an	an	DT
cord-253501-hkxlq3os	179	22	attractive	attractive	JJ
cord-253501-hkxlq3os	179	23	area	area	NN
cord-253501-hkxlq3os	179	24	of	of	IN
cord-253501-hkxlq3os	179	25	investigation	investigation	NN
cord-253501-hkxlq3os	179	26	.	.	.
cord-253501-hkxlq3os	180	1	Knowledge	knowledge	NN
cord-253501-hkxlq3os	180	2	of	of	IN
cord-253501-hkxlq3os	180	3	HEV	HEV	NNP
cord-253501-hkxlq3os	180	4	RNA	RNA	NNP
cord-253501-hkxlq3os	180	5	-	-	HYPH
cord-253501-hkxlq3os	180	6	dependent	dependent	JJ
cord-253501-hkxlq3os	180	7	RNA	RNA	NNP
cord-253501-hkxlq3os	180	8	polymerase	polymerase	NN
cord-253501-hkxlq3os	180	9	structure	structure	NN
cord-253501-hkxlq3os	180	10	might	may	MD
cord-253501-hkxlq3os	180	11	expedite	expedite	VB
cord-253501-hkxlq3os	180	12	the	the	DT
cord-253501-hkxlq3os	180	13	above	above	JJ
cord-253501-hkxlq3os	180	14	study	study	NN
cord-253501-hkxlq3os	180	15	.	.	.
cord-253501-hkxlq3os	181	1	Apart	apart	RB
cord-253501-hkxlq3os	181	2	from	from	IN
cord-253501-hkxlq3os	181	3	sofosbuvir	sofosbuvir	NN
cord-253501-hkxlq3os	181	4	-	-	HYPH
cord-253501-hkxlq3os	181	5	like	like	JJ
cord-253501-hkxlq3os	181	6	molecules	molecule	NNS
cord-253501-hkxlq3os	181	7	,	,	,
cord-253501-hkxlq3os	181	8	new	new	JJ
cord-253501-hkxlq3os	181	9	chemical	chemical	JJ
cord-253501-hkxlq3os	181	10	entities	entity	NNS
cord-253501-hkxlq3os	181	11	should	should	MD
cord-253501-hkxlq3os	181	12	be	be	VB
cord-253501-hkxlq3os	181	13	explored	explore	VBN
cord-253501-hkxlq3os	181	14	to	to	TO
cord-253501-hkxlq3os	181	15	identify	identify	VB
cord-253501-hkxlq3os	181	16	potent	potent	JJ
cord-253501-hkxlq3os	181	17	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	181	18	of	of	IN
cord-253501-hkxlq3os	181	19	HEV	HEV	NNP
cord-253501-hkxlq3os	181	20	RNA	RNA	NNP
cord-253501-hkxlq3os	181	21	-	-	HYPH
cord-253501-hkxlq3os	181	22	dependent	dependent	JJ
cord-253501-hkxlq3os	181	23	RNA	RNA	NNP
cord-253501-hkxlq3os	181	24	polymerase	polymerase	NN
cord-253501-hkxlq3os	181	25	activity	activity	NN
cord-253501-hkxlq3os	181	26	.	.	.
cord-253501-hkxlq3os	182	1	Other	other	JJ
cord-253501-hkxlq3os	182	2	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	182	3	of	of	IN
cord-253501-hkxlq3os	182	4	HEV	HEV	NNP
cord-253501-hkxlq3os	182	5	RNA	RNA	NNP
cord-253501-hkxlq3os	182	6	-	-	HYPH
cord-253501-hkxlq3os	182	7	dependent	dependent	JJ
cord-253501-hkxlq3os	182	8	RNA	RNA	NNP
cord-253501-hkxlq3os	182	9	polymerase	polymerase	NN
cord-253501-hkxlq3os	182	10	function	function	NN
cord-253501-hkxlq3os	183	1	:	:	:
cord-253501-hkxlq3os	183	2	Our	-PRON-	PRP$
cord-253501-hkxlq3os	183	3	earlier	early	JJR
cord-253501-hkxlq3os	183	4	studies	study	NNS
cord-253501-hkxlq3os	183	5	showed	show	VBD
cord-253501-hkxlq3os	183	6	that	that	IN
cord-253501-hkxlq3os	183	7	the	the	DT
cord-253501-hkxlq3os	183	8	interaction	interaction	NN
cord-253501-hkxlq3os	183	9	between	between	IN
cord-253501-hkxlq3os	183	10	host	host	NN
cord-253501-hkxlq3os	183	11	eEF1a1	eef1a1	NN
cord-253501-hkxlq3os	183	12	and	and	CC
cord-253501-hkxlq3os	183	13	viral	viral	JJ
cord-253501-hkxlq3os	183	14	RNA	rna	NN
cord-253501-hkxlq3os	183	15	-	-	HYPH
cord-253501-hkxlq3os	183	16	dependent	dependent	JJ
cord-253501-hkxlq3os	183	17	RNA	RNA	NNP
cord-253501-hkxlq3os	183	18	polymerase	polymerase	NN
cord-253501-hkxlq3os	183	19	is	be	VBZ
cord-253501-hkxlq3os	183	20	important	important	JJ
cord-253501-hkxlq3os	183	21	for	for	IN
cord-253501-hkxlq3os	183	22	optimal	optimal	JJ
cord-253501-hkxlq3os	183	23	RNA	rna	NN
cord-253501-hkxlq3os	183	24	-	-	HYPH
cord-253501-hkxlq3os	183	25	dependent	dependent	JJ
cord-253501-hkxlq3os	183	26	RNA	RNA	NNP
cord-253501-hkxlq3os	183	27	polymerase	polymerase	NN
cord-253501-hkxlq3os	183	28	activity	activity	NN
cord-253501-hkxlq3os	183	29	.	.	.
cord-253501-hkxlq3os	184	1	77	77	CD
cord-253501-hkxlq3os	185	1	We	-PRON-	PRP
cord-253501-hkxlq3os	185	2	recently	recently	RB
cord-253501-hkxlq3os	185	3	reported	report	VBD
cord-253501-hkxlq3os	185	4	the	the	DT
cord-253501-hkxlq3os	185	5	construction	construction	NN
cord-253501-hkxlq3os	185	6	and	and	CC
cord-253501-hkxlq3os	185	7	characterization	characterization	NN
cord-253501-hkxlq3os	185	8	of	of	IN
cord-253501-hkxlq3os	185	9	the	the	DT
cord-253501-hkxlq3os	185	10	host	host	NN
cord-253501-hkxlq3os	185	11	-	-	HYPH
cord-253501-hkxlq3os	185	12	virus	virus	NN
cord-253501-hkxlq3os	185	13	protein	protein	NN
cord-253501-hkxlq3os	185	14	-	-	HYPH
cord-253501-hkxlq3os	185	15	protein	protein	NN
cord-253501-hkxlq3os	185	16	interaction	interaction	NN
cord-253501-hkxlq3os	185	17	network	network	NN
cord-253501-hkxlq3os	185	18	of	of	IN
cord-253501-hkxlq3os	185	19	HEV	HEV	NNP
cord-253501-hkxlq3os	185	20	.	.	.
cord-253501-hkxlq3os	186	1	78	78	CD
cord-253501-hkxlq3os	187	1	Using	use	VBG
cord-253501-hkxlq3os	187	2	a	a	DT
cord-253501-hkxlq3os	187	3	yeast	yeast	NN
cord-253501-hkxlq3os	187	4	two	two	CD
cord-253501-hkxlq3os	187	5	-	-	HYPH
cord-253501-hkxlq3os	187	6	hybrid	hybrid	NN
cord-253501-hkxlq3os	187	7	cDNA	cdna	NN
cord-253501-hkxlq3os	187	8	library	library	NN
cord-253501-hkxlq3os	187	9	screening	screening	NN
cord-253501-hkxlq3os	187	10	-	-	HYPH
cord-253501-hkxlq3os	187	11	based	base	VBN
cord-253501-hkxlq3os	187	12	approach	approach	NN
cord-253501-hkxlq3os	187	13	,	,	,
cord-253501-hkxlq3os	187	14	41	41	CD
cord-253501-hkxlq3os	187	15	host	host	NN
cord-253501-hkxlq3os	187	16	proteins	protein	NNS
cord-253501-hkxlq3os	187	17	were	be	VBD
cord-253501-hkxlq3os	187	18	identified	identify	VBN
cord-253501-hkxlq3os	187	19	to	to	TO
cord-253501-hkxlq3os	187	20	be	be	VB
cord-253501-hkxlq3os	187	21	the	the	DT
cord-253501-hkxlq3os	187	22	direct	direct	JJ
cord-253501-hkxlq3os	187	23	interaction	interaction	NN
cord-253501-hkxlq3os	187	24	partners	partner	NNS
cord-253501-hkxlq3os	187	25	of	of	IN
cord-253501-hkxlq3os	187	26	g-1	g-1	NNP
cord-253501-hkxlq3os	187	27	HEV	HEV	NNP
cord-253501-hkxlq3os	187	28	RNA	RNA	NNP
cord-253501-hkxlq3os	187	29	-	-	HYPH
cord-253501-hkxlq3os	187	30	dependent	dependent	JJ
cord-253501-hkxlq3os	187	31	RNA	RNA	NNP
cord-253501-hkxlq3os	187	32	polymerase	polymerase	NN
cord-253501-hkxlq3os	187	33	and	and	CC
cord-253501-hkxlq3os	187	34	23	23	CD
cord-253501-hkxlq3os	187	35	of	of	IN
cord-253501-hkxlq3os	187	36	them	-PRON-	PRP
cord-253501-hkxlq3os	187	37	could	could	MD
cord-253501-hkxlq3os	187	38	also	also	RB
cord-253501-hkxlq3os	187	39	associate	associate	VB
cord-253501-hkxlq3os	187	40	with	with	IN
cord-253501-hkxlq3os	187	41	g3-HEV	g3-HEV	NNP
cord-253501-hkxlq3os	187	42	RNA	RNA	NNP
cord-253501-hkxlq3os	187	43	-	-	HYPH
cord-253501-hkxlq3os	187	44	dependent	dependent	JJ
cord-253501-hkxlq3os	187	45	RNA	RNA	NNP
cord-253501-hkxlq3os	187	46	polymerase	polymerase	NN
cord-253501-hkxlq3os	187	47	.	.	.
cord-253501-hkxlq3os	188	1	Notably	notably	RB
cord-253501-hkxlq3os	188	2	,	,	,
cord-253501-hkxlq3os	188	3	host	host	NN
cord-253501-hkxlq3os	188	4	translation	translation	NN
cord-253501-hkxlq3os	188	5	regulatory	regulatory	JJ
cord-253501-hkxlq3os	188	6	factors	factor	NNS
cord-253501-hkxlq3os	188	7	,	,	,
cord-253501-hkxlq3os	188	8	such	such	JJ
cord-253501-hkxlq3os	188	9	as	as	IN
cord-253501-hkxlq3os	188	10	eIF4A2	eIF4A2	NNP
cord-253501-hkxlq3os	188	11	,	,	,
cord-253501-hkxlq3os	188	12	eEF1a1	eef1a1	NN
cord-253501-hkxlq3os	188	13	and	and	CC
cord-253501-hkxlq3os	188	14	eIF3A	eif3a	CD
cord-253501-hkxlq3os	188	15	,	,	,
cord-253501-hkxlq3os	188	16	directly	directly	RB
cord-253501-hkxlq3os	188	17	associated	associate	VBN
cord-253501-hkxlq3os	188	18	with	with	IN
cord-253501-hkxlq3os	188	19	the	the	DT
cord-253501-hkxlq3os	188	20	RNA	RNA	NNP
cord-253501-hkxlq3os	188	21	-	-	HYPH
cord-253501-hkxlq3os	188	22	dependent	dependent	JJ
cord-253501-hkxlq3os	188	23	RNA	RNA	NNP
cord-253501-hkxlq3os	188	24	polymerase	polymerase	NN
cord-253501-hkxlq3os	188	25	protein	protein	NN
cord-253501-hkxlq3os	188	26	of	of	IN
cord-253501-hkxlq3os	188	27	both	both	DT
cord-253501-hkxlq3os	188	28	genotype	genotype	NN
cord-253501-hkxlq3os	188	29	1	1	CD
cord-253501-hkxlq3os	188	30	and	and	CC
cord-253501-hkxlq3os	188	31	genotype	genotype	NN
cord-253501-hkxlq3os	188	32	3	3	CD
cord-253501-hkxlq3os	188	33	HEV	hev	NN
cord-253501-hkxlq3os	188	34	.	.	.
cord-253501-hkxlq3os	189	1	Further	further	RB
cord-253501-hkxlq3os	189	2	in	in	IN
cord-253501-hkxlq3os	189	3	silico	silico	NN
cord-253501-hkxlq3os	189	4	analysis	analysis	NN
cord-253501-hkxlq3os	189	5	of	of	IN
cord-253501-hkxlq3os	189	6	the	the	DT
cord-253501-hkxlq3os	189	7	functional	functional	JJ
cord-253501-hkxlq3os	189	8	significance	significance	NN
cord-253501-hkxlq3os	189	9	of	of	IN
cord-253501-hkxlq3os	189	10	the	the	DT
cord-253501-hkxlq3os	189	11	protein	protein	NN
cord-253501-hkxlq3os	189	12	-	-	HYPH
cord-253501-hkxlq3os	189	13	protein	protein	NN
cord-253501-hkxlq3os	189	14	interaction	interaction	NN
cord-253501-hkxlq3os	189	15	network	network	NN
cord-253501-hkxlq3os	189	16	revealed	reveal	VBD
cord-253501-hkxlq3os	189	17	distinct	distinct	JJ
cord-253501-hkxlq3os	189	18	protein	protein	NN
cord-253501-hkxlq3os	189	19	-	-	HYPH
cord-253501-hkxlq3os	189	20	protein	protein	NN
cord-253501-hkxlq3os	189	21	interaction	interaction	NN
cord-253501-hkxlq3os	189	22	clusters	cluster	NNS
cord-253501-hkxlq3os	189	23	in	in	IN
cord-253501-hkxlq3os	189	24	the	the	DT
cord-253501-hkxlq3os	189	25	secondary	secondary	JJ
cord-253501-hkxlq3os	189	26	network	network	NN
cord-253501-hkxlq3os	189	27	,	,	,
cord-253501-hkxlq3os	189	28	representing	represent	VBG
cord-253501-hkxlq3os	189	29	enrichment	enrichment	NN
cord-253501-hkxlq3os	189	30	of	of	IN
cord-253501-hkxlq3os	189	31	proteins	protein	NNS
cord-253501-hkxlq3os	189	32	involved	involve	VBN
cord-253501-hkxlq3os	189	33	in	in	IN
cord-253501-hkxlq3os	189	34	different	different	JJ
cord-253501-hkxlq3os	189	35	host	host	NN
cord-253501-hkxlq3os	189	36	processes	process	NNS
cord-253501-hkxlq3os	189	37	,	,	,
cord-253501-hkxlq3os	189	38	such	such	JJ
cord-253501-hkxlq3os	189	39	as	as	IN
cord-253501-hkxlq3os	189	40	translation	translation	NN
cord-253501-hkxlq3os	189	41	initiation	initiation	NN
cord-253501-hkxlq3os	189	42	,	,	,
cord-253501-hkxlq3os	189	43	the	the	DT
cord-253501-hkxlq3os	189	44	ubiquitin	ubiquitin	NN
cord-253501-hkxlq3os	189	45	proteasome	proteasome	NN
cord-253501-hkxlq3os	189	46	pathway	pathway	NN
cord-253501-hkxlq3os	189	47	and	and	CC
cord-253501-hkxlq3os	189	48	the	the	DT
cord-253501-hkxlq3os	189	49	oxidative	oxidative	JJ
cord-253501-hkxlq3os	189	50	phosphorylation	phosphorylation	NN
cord-253501-hkxlq3os	189	51	pathway	pathway	NN
cord-253501-hkxlq3os	189	52	.	.	.
cord-253501-hkxlq3os	190	1	Depletion	depletion	NN
cord-253501-hkxlq3os	190	2	of	of	IN
cord-253501-hkxlq3os	190	3	the	the	DT
cord-253501-hkxlq3os	190	4	translation	translation	NN
cord-253501-hkxlq3os	190	5	regulatory	regulatory	JJ
cord-253501-hkxlq3os	190	6	factors	factor	NNS
cord-253501-hkxlq3os	190	7	by	by	IN
cord-253501-hkxlq3os	190	8	gene	gene	NN
cord-253501-hkxlq3os	190	9	silencing	silencing	NN
cord-253501-hkxlq3os	190	10	technique	technique	NN
cord-253501-hkxlq3os	190	11	resulted	result	VBD
cord-253501-hkxlq3os	190	12	in	in	IN
cord-253501-hkxlq3os	190	13	significant	significant	JJ
cord-253501-hkxlq3os	190	14	reduction	reduction	NN
cord-253501-hkxlq3os	190	15	of	of	IN
cord-253501-hkxlq3os	190	16	viral	viral	JJ
cord-253501-hkxlq3os	190	17	replication	replication	NN
cord-253501-hkxlq3os	190	18	and	and	CC
cord-253501-hkxlq3os	190	19	pull	pull	VB
cord-253501-hkxlq3os	190	20	-	-	HYPH
cord-253501-hkxlq3os	190	21	down	down	RP
cord-253501-hkxlq3os	190	22	studies	study	NNS
cord-253501-hkxlq3os	190	23	under	under	IN
cord-253501-hkxlq3os	190	24	similar	similar	JJ
cord-253501-hkxlq3os	190	25	conditions	condition	NNS
cord-253501-hkxlq3os	190	26	revealed	reveal	VBD
cord-253501-hkxlq3os	190	27	the	the	DT
cord-253501-hkxlq3os	190	28	assembly	assembly	NN
cord-253501-hkxlq3os	190	29	of	of	IN
cord-253501-hkxlq3os	190	30	a	a	DT
cord-253501-hkxlq3os	190	31	multiprotein	multiprotein	NNP
cord-253501-hkxlq3os	190	32	complex	complex	NN
cord-253501-hkxlq3os	190	33	consisting	consisting	NN
cord-253501-hkxlq3os	190	34	of	of	IN
cord-253501-hkxlq3os	190	35	the	the	DT
cord-253501-hkxlq3os	190	36	translation	translation	NN
cord-253501-hkxlq3os	190	37	regulatory	regulatory	JJ
cord-253501-hkxlq3os	190	38	factors	factor	NNS
cord-253501-hkxlq3os	190	39	,	,	,
cord-253501-hkxlq3os	190	40	RNA	rna	NN
cord-253501-hkxlq3os	190	41	-	-	HYPH
cord-253501-hkxlq3os	190	42	dependent	dependent	JJ
cord-253501-hkxlq3os	190	43	RNA	RNA	NNP
cord-253501-hkxlq3os	190	44	polymerase	polymerase	NN
cord-253501-hkxlq3os	190	45	and	and	CC
cord-253501-hkxlq3os	190	46	many	many	JJ
cord-253501-hkxlq3os	190	47	other	other	JJ
cord-253501-hkxlq3os	190	48	virus	virus	NN
cord-253501-hkxlq3os	190	49	and	and	CC
cord-253501-hkxlq3os	190	50	host	host	NN
cord-253501-hkxlq3os	190	51	factors	factor	NNS
cord-253501-hkxlq3os	190	52	.	.	.
cord-253501-hkxlq3os	191	1	Remarkably	remarkably	RB
cord-253501-hkxlq3os	191	2	,	,	,
cord-253501-hkxlq3os	191	3	eEF1a1	eEF1a1	NNP
cord-253501-hkxlq3os	191	4	was	be	VBD
cord-253501-hkxlq3os	191	5	identified	identify	VBN
cord-253501-hkxlq3os	191	6	to	to	TO
cord-253501-hkxlq3os	191	7	be	be	VB
cord-253501-hkxlq3os	191	8	the	the	DT
cord-253501-hkxlq3os	191	9	most	most	RBS
cord-253501-hkxlq3os	191	10	important	important	JJ
cord-253501-hkxlq3os	191	11	host	host	NN
cord-253501-hkxlq3os	191	12	factor	factor	NN
cord-253501-hkxlq3os	191	13	for	for	IN
cord-253501-hkxlq3os	191	14	maintaining	maintain	VBG
cord-253501-hkxlq3os	191	15	the	the	DT
cord-253501-hkxlq3os	191	16	integrity	integrity	NN
cord-253501-hkxlq3os	191	17	of	of	IN
cord-253501-hkxlq3os	191	18	the	the	DT
cord-253501-hkxlq3os	191	19	above	above	JJ
cord-253501-hkxlq3os	191	20	multiprotein	multiprotein	NNP
cord-253501-hkxlq3os	191	21	complex	complex	NNP
cord-253501-hkxlq3os	191	22	,	,	,
cord-253501-hkxlq3os	191	23	thereby	thereby	RB
cord-253501-hkxlq3os	191	24	suggesting	suggest	VBG
cord-253501-hkxlq3os	191	25	it	-PRON-	PRP
cord-253501-hkxlq3os	191	26	to	to	TO
cord-253501-hkxlq3os	191	27	be	be	VB
cord-253501-hkxlq3os	191	28	an	an	DT
cord-253501-hkxlq3os	191	29	attractive	attractive	JJ
cord-253501-hkxlq3os	191	30	target	target	NN
cord-253501-hkxlq3os	191	31	for	for	IN
cord-253501-hkxlq3os	191	32	antiviral	antiviral	JJ
cord-253501-hkxlq3os	191	33	discovery	discovery	NN
cord-253501-hkxlq3os	191	34	.	.	.
cord-253501-hkxlq3os	192	1	Additionally	additionally	RB
cord-253501-hkxlq3os	192	2	,	,	,
cord-253501-hkxlq3os	192	3	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	192	4	against	against	IN
cord-253501-hkxlq3os	192	5	other	other	JJ
cord-253501-hkxlq3os	192	6	host	host	NN
cord-253501-hkxlq3os	192	7	translation	translation	NN
cord-253501-hkxlq3os	192	8	factors	factor	NNS
cord-253501-hkxlq3os	192	9	present	present	JJ
cord-253501-hkxlq3os	192	10	in	in	IN
cord-253501-hkxlq3os	192	11	the	the	DT
cord-253501-hkxlq3os	192	12	complex	complex	NN
cord-253501-hkxlq3os	192	13	such	such	JJ
cord-253501-hkxlq3os	192	14	as	as	IN
cord-253501-hkxlq3os	192	15	eIF4A2	eIF4A2	NNP
cord-253501-hkxlq3os	192	16	and	and	CC
cord-253501-hkxlq3os	192	17	eIF3A	eif3a	CD
cord-253501-hkxlq3os	192	18	are	be	VBP
cord-253501-hkxlq3os	192	19	also	also	RB
cord-253501-hkxlq3os	192	20	supposed	suppose	VBN
cord-253501-hkxlq3os	192	21	to	to	TO
cord-253501-hkxlq3os	192	22	block	block	VB
cord-253501-hkxlq3os	192	23	viral	viral	JJ
cord-253501-hkxlq3os	192	24	replication	replication	NN
cord-253501-hkxlq3os	192	25	.	.	.
cord-253501-hkxlq3os	193	1	Targeting	target	VBG
cord-253501-hkxlq3os	193	2	a	a	DT
cord-253501-hkxlq3os	193	3	combination	combination	NN
cord-253501-hkxlq3os	193	4	of	of	IN
cord-253501-hkxlq3os	193	5	direct	direct	JJ
cord-253501-hkxlq3os	193	6	and	and	CC
cord-253501-hkxlq3os	193	7	indirect	indirect	JJ
cord-253501-hkxlq3os	193	8	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	193	9	of	of	IN
cord-253501-hkxlq3os	193	10	RNA	RNA	NNP
cord-253501-hkxlq3os	193	11	-	-	HYPH
cord-253501-hkxlq3os	193	12	dependent	dependent	JJ
cord-253501-hkxlq3os	193	13	RNA	RNA	NNP
cord-253501-hkxlq3os	193	14	polymerase	polymerase	NN
cord-253501-hkxlq3os	193	15	function	function	NN
cord-253501-hkxlq3os	193	16	might	may	MD
cord-253501-hkxlq3os	193	17	prove	prove	VB
cord-253501-hkxlq3os	193	18	to	to	TO
cord-253501-hkxlq3os	193	19	be	be	VB
cord-253501-hkxlq3os	193	20	an	an	DT
cord-253501-hkxlq3os	193	21	apt	apt	JJ
cord-253501-hkxlq3os	193	22	antiviral	antiviral	JJ
cord-253501-hkxlq3os	193	23	strategy	strategy	NN
cord-253501-hkxlq3os	193	24	against	against	IN
cord-253501-hkxlq3os	193	25	HEV	HEV	NNP
cord-253501-hkxlq3os	193	26	.	.	.
cord-253501-hkxlq3os	194	1	Inhibitors	Inhibitors	NNP
cord-253501-hkxlq3os	194	2	of	of	IN
cord-253501-hkxlq3os	194	3	helicase	helicase	NN
cord-253501-hkxlq3os	194	4	function	function	NN
cord-253501-hkxlq3os	194	5	:	:	:
cord-253501-hkxlq3os	194	6	HEV	HEV	NNP
cord-253501-hkxlq3os	194	7	helicase	helicase	NNP
cord-253501-hkxlq3os	194	8	is	be	VBZ
cord-253501-hkxlq3os	194	9	a	a	DT
cord-253501-hkxlq3os	194	10	nucleoside	nucleoside	NN
cord-253501-hkxlq3os	194	11	triphosphatase	triphosphatase	NN
cord-253501-hkxlq3os	194	12	with	with	IN
cord-253501-hkxlq3os	194	13	the	the	DT
cord-253501-hkxlq3os	194	14	ability	ability	NN
cord-253501-hkxlq3os	194	15	to	to	TO
cord-253501-hkxlq3os	194	16	unwind	unwind	VB
cord-253501-hkxlq3os	194	17	RNA	RNA	NNP
cord-253501-hkxlq3os	194	18	duplexes	duplex	NNS
cord-253501-hkxlq3os	194	19	in	in	IN
cord-253501-hkxlq3os	194	20	the	the	DT
cord-253501-hkxlq3os	194	21	5′	5′	CD
cord-253501-hkxlq3os	194	22	to	to	IN
cord-253501-hkxlq3os	194	23	3′	3′	CD
cord-253501-hkxlq3os	194	24	direction	direction	NN
cord-253501-hkxlq3os	194	25	,	,	,
cord-253501-hkxlq3os	194	26	thus	thus	RB
cord-253501-hkxlq3os	194	27	playing	play	VBG
cord-253501-hkxlq3os	194	28	a	a	DT
cord-253501-hkxlq3os	194	29	role	role	NN
cord-253501-hkxlq3os	194	30	in	in	IN
cord-253501-hkxlq3os	194	31	HEV	HEV	NNP
cord-253501-hkxlq3os	194	32	replication	replication	NN
cord-253501-hkxlq3os	194	33	.	.	.
cord-253501-hkxlq3os	195	1	79	79	CD
cord-253501-hkxlq3os	196	1	Due	due	IN
cord-253501-hkxlq3os	196	2	to	to	IN
cord-253501-hkxlq3os	196	3	the	the	DT
cord-253501-hkxlq3os	196	4	common	common	JJ
cord-253501-hkxlq3os	196	5	properties	property	NNS
cord-253501-hkxlq3os	196	6	shared	share	VBN
cord-253501-hkxlq3os	196	7	between	between	IN
cord-253501-hkxlq3os	196	8	the	the	DT
cord-253501-hkxlq3os	196	9	helicases	helicase	NNS
cord-253501-hkxlq3os	196	10	encoded	encode	VBN
cord-253501-hkxlq3os	196	11	by	by	IN
cord-253501-hkxlq3os	196	12	viruses	virus	NNS
cord-253501-hkxlq3os	196	13	and	and	CC
cord-253501-hkxlq3os	196	14	their	-PRON-	PRP$
cord-253501-hkxlq3os	196	15	host	host	NN
cord-253501-hkxlq3os	196	16	,	,	,
cord-253501-hkxlq3os	196	17	designing	design	VBG
cord-253501-hkxlq3os	196	18	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	196	19	against	against	IN
cord-253501-hkxlq3os	196	20	helicases	helicase	NNS
cord-253501-hkxlq3os	196	21	is	be	VBZ
cord-253501-hkxlq3os	196	22	challenging	challenging	JJ
cord-253501-hkxlq3os	196	23	.	.	.
cord-253501-hkxlq3os	197	1	Nevertheless	nevertheless	RB
cord-253501-hkxlq3os	197	2	,	,	,
cord-253501-hkxlq3os	197	3	potent	potent	JJ
cord-253501-hkxlq3os	197	4	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	197	5	of	of	IN
cord-253501-hkxlq3os	197	6	helicase	helicase	NN
cord-253501-hkxlq3os	197	7	encoded	encode	VBN
cord-253501-hkxlq3os	197	8	by	by	IN
cord-253501-hkxlq3os	197	9	the	the	DT
cord-253501-hkxlq3os	197	10	herpes	herpes	NNP
cord-253501-hkxlq3os	197	11	simplex	simplex	NNP
cord-253501-hkxlq3os	197	12	virus	virus	NN
cord-253501-hkxlq3os	197	13	,	,	,
cord-253501-hkxlq3os	197	14	severe	severe	JJ
cord-253501-hkxlq3os	197	15	acute	acute	JJ
cord-253501-hkxlq3os	197	16	respiratory	respiratory	JJ
cord-253501-hkxlq3os	197	17	syndrome	syndrome	NN
cord-253501-hkxlq3os	197	18	coronavirus	coronavirus	NN
cord-253501-hkxlq3os	197	19	,	,	,
cord-253501-hkxlq3os	197	20	HCV	HCV	NNP
cord-253501-hkxlq3os	197	21	,	,	,
cord-253501-hkxlq3os	197	22	dengue	dengue	NN
cord-253501-hkxlq3os	197	23	virus	virus	NN
cord-253501-hkxlq3os	197	24	,	,	,
cord-253501-hkxlq3os	197	25	Japanese	japanese	JJ
cord-253501-hkxlq3os	197	26	encephalitis	encephalitis	RB
cord-253501-hkxlq3os	197	27	virus	virus	NN
cord-253501-hkxlq3os	197	28	,	,	,
cord-253501-hkxlq3os	197	29	West	West	NNP
cord-253501-hkxlq3os	197	30	Nile	Nile	NNP
cord-253501-hkxlq3os	197	31	virus	virus	NN
cord-253501-hkxlq3os	197	32	and	and	CC
cord-253501-hkxlq3os	197	33	human	human	JJ
cord-253501-hkxlq3os	197	34	papillomavirus	papillomavirus	NN
cord-253501-hkxlq3os	197	35	have	have	VBP
cord-253501-hkxlq3os	197	36	been	be	VBN
cord-253501-hkxlq3os	197	37	reported	report	VBN
cord-253501-hkxlq3os	197	38	.	.	.
cord-253501-hkxlq3os	198	1	80	80	CD
cord-253501-hkxlq3os	198	2	 	 	_SP
cord-253501-hkxlq3os	198	3	Release	Release	NNP
cord-253501-hkxlq3os	198	4	of	of	IN
cord-253501-hkxlq3os	198	5	the	the	DT
cord-253501-hkxlq3os	198	6	progeny	progeny	JJ
cord-253501-hkxlq3os	198	7	virions	virion	NNS
cord-253501-hkxlq3os	198	8	from	from	IN
cord-253501-hkxlq3os	198	9	infected	infected	JJ
cord-253501-hkxlq3os	198	10	cells	cell	NNS
cord-253501-hkxlq3os	198	11	leads	lead	VBZ
cord-253501-hkxlq3os	198	12	to	to	IN
cord-253501-hkxlq3os	198	13	the	the	DT
cord-253501-hkxlq3os	198	14	infection	infection	NN
cord-253501-hkxlq3os	198	15	of	of	IN
cord-253501-hkxlq3os	198	16	neighboring	neighbor	VBG
cord-253501-hkxlq3os	198	17	uninfected	uninfected	JJ
cord-253501-hkxlq3os	198	18	cells	cell	NNS
cord-253501-hkxlq3os	198	19	,	,	,
cord-253501-hkxlq3os	198	20	thus	thus	RB
cord-253501-hkxlq3os	198	21	amplifying	amplify	VBG
cord-253501-hkxlq3os	198	22	the	the	DT
cord-253501-hkxlq3os	198	23	unwanted	unwanted	JJ
cord-253501-hkxlq3os	198	24	consequences	consequence	NNS
cord-253501-hkxlq3os	198	25	.	.	.
cord-253501-hkxlq3os	199	1	Antivirals	antiviral	NNS
cord-253501-hkxlq3os	199	2	that	that	WDT
cord-253501-hkxlq3os	199	3	prevent	prevent	VBP
cord-253501-hkxlq3os	199	4	the	the	DT
cord-253501-hkxlq3os	199	5	release	release	NN
cord-253501-hkxlq3os	199	6	of	of	IN
cord-253501-hkxlq3os	199	7	the	the	DT
cord-253501-hkxlq3os	199	8	progeny	progeny	JJ
cord-253501-hkxlq3os	199	9	virus	virus	NN
cord-253501-hkxlq3os	199	10	will	will	MD
cord-253501-hkxlq3os	199	11	prevent	prevent	VB
cord-253501-hkxlq3os	199	12	further	further	JJ
cord-253501-hkxlq3os	199	13	infection	infection	NN
cord-253501-hkxlq3os	199	14	,	,	,
cord-253501-hkxlq3os	199	15	thereby	thereby	RB
cord-253501-hkxlq3os	199	16	minimizing	minimize	VBG
cord-253501-hkxlq3os	199	17	progression	progression	NN
cord-253501-hkxlq3os	199	18	of	of	IN
cord-253501-hkxlq3os	199	19	the	the	DT
cord-253501-hkxlq3os	199	20	disease	disease	NN
cord-253501-hkxlq3os	199	21	.	.	.
cord-253501-hkxlq3os	200	1	Release	release	NN
cord-253501-hkxlq3os	200	2	of	of	IN
cord-253501-hkxlq3os	200	3	the	the	DT
cord-253501-hkxlq3os	200	4	newly	newly	RB
cord-253501-hkxlq3os	200	5	assembled	assemble	VBN
cord-253501-hkxlq3os	200	6	virus	virus	NN
cord-253501-hkxlq3os	200	7	from	from	IN
cord-253501-hkxlq3os	200	8	an	an	DT
cord-253501-hkxlq3os	200	9	infected	infected	JJ
cord-253501-hkxlq3os	200	10	cell	cell	NN
cord-253501-hkxlq3os	200	11	is	be	VBZ
cord-253501-hkxlq3os	200	12	a	a	DT
cord-253501-hkxlq3os	200	13	complicated	complicated	JJ
cord-253501-hkxlq3os	200	14	process	process	NN
cord-253501-hkxlq3os	200	15	involving	involve	VBG
cord-253501-hkxlq3os	200	16	multiple	multiple	JJ
cord-253501-hkxlq3os	200	17	protein	protein	NN
cord-253501-hkxlq3os	200	18	-	-	HYPH
cord-253501-hkxlq3os	200	19	protein	protein	NN
cord-253501-hkxlq3os	200	20	interactions	interaction	NNS
cord-253501-hkxlq3os	200	21	between	between	IN
cord-253501-hkxlq3os	200	22	the	the	DT
cord-253501-hkxlq3os	200	23	virus	virus	NN
cord-253501-hkxlq3os	200	24	and	and	CC
cord-253501-hkxlq3os	200	25	host	host	NN
cord-253501-hkxlq3os	200	26	factors	factor	NNS
cord-253501-hkxlq3os	200	27	.	.	.
cord-253501-hkxlq3os	201	1	82	82	CD
cord-253501-hkxlq3os	202	1	A	a	DT
cord-253501-hkxlq3os	202	2	thorough	thorough	JJ
cord-253501-hkxlq3os	202	3	understanding	understanding	NN
cord-253501-hkxlq3os	202	4	of	of	IN
cord-253501-hkxlq3os	202	5	such	such	JJ
cord-253501-hkxlq3os	202	6	interactions	interaction	NNS
cord-253501-hkxlq3os	202	7	will	will	MD
cord-253501-hkxlq3os	202	8	help	help	VB
cord-253501-hkxlq3os	202	9	in	in	IN
cord-253501-hkxlq3os	202	10	decoding	decode	VBG
cord-253501-hkxlq3os	202	11	the	the	DT
cord-253501-hkxlq3os	202	12	mechanism	mechanism	NN
cord-253501-hkxlq3os	202	13	underlying	underlie	VBG
cord-253501-hkxlq3os	202	14	virus	virus	NN
cord-253501-hkxlq3os	202	15	release	release	NN
cord-253501-hkxlq3os	202	16	.	.	.
cord-253501-hkxlq3os	203	1	An	an	DT
cord-253501-hkxlq3os	203	2	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	203	3	of	of	IN
cord-253501-hkxlq3os	203	4	human	human	JJ
cord-253501-hkxlq3os	203	5	immunodeficiency	immunodeficiency	NN
cord-253501-hkxlq3os	203	6	virus	virus	NN
cord-253501-hkxlq3os	203	7	release	release	NN
cord-253501-hkxlq3os	203	8	has	have	VBZ
cord-253501-hkxlq3os	203	9	been	be	VBN
cord-253501-hkxlq3os	203	10	identified	identify	VBN
cord-253501-hkxlq3os	203	11	,	,	,
cord-253501-hkxlq3os	203	12	which	which	WDT
cord-253501-hkxlq3os	203	13	acts	act	VBZ
cord-253501-hkxlq3os	203	14	by	by	IN
cord-253501-hkxlq3os	203	15	blocking	block	VBG
cord-253501-hkxlq3os	203	16	the	the	DT
cord-253501-hkxlq3os	203	17	interaction	interaction	NN
cord-253501-hkxlq3os	203	18	between	between	IN
cord-253501-hkxlq3os	203	19	the	the	DT
cord-253501-hkxlq3os	203	20	viral	viral	JJ
cord-253501-hkxlq3os	203	21	gag	gag	NN
cord-253501-hkxlq3os	203	22	and	and	CC
cord-253501-hkxlq3os	203	23	host	host	NN
cord-253501-hkxlq3os	203	24	tumor	tumor	NN
cord-253501-hkxlq3os	203	25	susceptibility	susceptibility	NN
cord-253501-hkxlq3os	203	26	gene	gene	NN
cord-253501-hkxlq3os	203	27	101encoded	101encode	VBN
cord-253501-hkxlq3os	203	28	proteins	protein	NNS
cord-253501-hkxlq3os	203	29	.	.	.
cord-253501-hkxlq3os	204	1	83	83	CD
cord-253501-hkxlq3os	204	2	Interaction	interaction	NN
cord-253501-hkxlq3os	204	3	between	between	IN
cord-253501-hkxlq3os	204	4	HEV	HEV	NNP
cord-253501-hkxlq3os	204	5	ORF3	ORF3	NNP
cord-253501-hkxlq3os	204	6	and	and	CC
cord-253501-hkxlq3os	204	7	host	host	NN
cord-253501-hkxlq3os	204	8	tumor	tumor	NN
cord-253501-hkxlq3os	204	9	susceptibility	susceptibility	NN
cord-253501-hkxlq3os	204	10	gene	gene	NN
cord-253501-hkxlq3os	204	11	101-encoded	101-encoded	CD
cord-253501-hkxlq3os	204	12	protein	protein	NN
cord-253501-hkxlq3os	204	13	is	be	VBZ
cord-253501-hkxlq3os	204	14	also	also	RB
cord-253501-hkxlq3os	204	15	known	know	VBN
cord-253501-hkxlq3os	204	16	to	to	TO
cord-253501-hkxlq3os	204	17	mediate	mediate	VB
cord-253501-hkxlq3os	204	18	the	the	DT
cord-253501-hkxlq3os	204	19	release	release	NN
cord-253501-hkxlq3os	204	20	of	of	IN
cord-253501-hkxlq3os	204	21	genotype	genotype	NN
cord-253501-hkxlq3os	204	22	3	3	CD
cord-253501-hkxlq3os	204	23	HEV	hev	NN
cord-253501-hkxlq3os	204	24	.	.	.
cord-253501-hkxlq3os	205	1	84	84	CD
cord-253501-hkxlq3os	205	2	,	,	,
cord-253501-hkxlq3os	205	3	85	85	CD
cord-253501-hkxlq3os	206	1	An	an	DT
cord-253501-hkxlq3os	206	2	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	206	3	against	against	IN
cord-253501-hkxlq3os	206	4	the	the	DT
cord-253501-hkxlq3os	206	5	above	above	JJ
cord-253501-hkxlq3os	206	6	interaction	interaction	NN
cord-253501-hkxlq3os	206	7	may	may	MD
cord-253501-hkxlq3os	206	8	prove	prove	VB
cord-253501-hkxlq3os	206	9	to	to	TO
cord-253501-hkxlq3os	206	10	be	be	VB
cord-253501-hkxlq3os	206	11	a	a	DT
cord-253501-hkxlq3os	206	12	potent	potent	JJ
cord-253501-hkxlq3os	206	13	antiviral	antiviral	JJ
cord-253501-hkxlq3os	206	14	against	against	IN
cord-253501-hkxlq3os	206	15	HEV	HEV	NNP
cord-253501-hkxlq3os	206	16	.	.	.
cord-253501-hkxlq3os	207	1	Apart	apart	RB
cord-253501-hkxlq3os	207	2	from	from	IN
cord-253501-hkxlq3os	207	3	that	that	DT
cord-253501-hkxlq3os	207	4	,	,	,
cord-253501-hkxlq3os	207	5	detailed	detailed	JJ
cord-253501-hkxlq3os	207	6	investigation	investigation	NN
cord-253501-hkxlq3os	207	7	of	of	IN
cord-253501-hkxlq3os	207	8	HEV	HEV	NNP
cord-253501-hkxlq3os	207	9	release	release	NN
cord-253501-hkxlq3os	207	10	mechanism	mechanism	NN
cord-253501-hkxlq3os	207	11	should	should	MD
cord-253501-hkxlq3os	207	12	identify	identify	VB
cord-253501-hkxlq3os	207	13	additional	additional	JJ
cord-253501-hkxlq3os	207	14	targets	target	NNS
cord-253501-hkxlq3os	207	15	for	for	IN
cord-253501-hkxlq3os	207	16	antiviral	antiviral	JJ
cord-253501-hkxlq3os	207	17	development	development	NN
cord-253501-hkxlq3os	207	18	.	.	.
cord-253501-hkxlq3os	208	1	The	the	DT
cord-253501-hkxlq3os	208	2	advantages	advantage	NNS
cord-253501-hkxlq3os	208	3	of	of	IN
cord-253501-hkxlq3os	208	4	using	use	VBG
cord-253501-hkxlq3os	208	5	antivirals	antiviral	NNS
cord-253501-hkxlq3os	208	6	,	,	,
cord-253501-hkxlq3os	208	7	particularly	particularly	RB
cord-253501-hkxlq3os	208	8	to	to	TO
cord-253501-hkxlq3os	208	9	cut	cut	VB
cord-253501-hkxlq3os	208	10	off	off	RP
cord-253501-hkxlq3os	208	11	the	the	DT
cord-253501-hkxlq3os	208	12	disease	disease	NN
cord-253501-hkxlq3os	208	13	in	in	IN
cord-253501-hkxlq3os	208	14	an	an	DT
cord-253501-hkxlq3os	208	15	infected	infected	JJ
cord-253501-hkxlq3os	208	16	person	person	NN
cord-253501-hkxlq3os	208	17	and	and	CC
cord-253501-hkxlq3os	208	18	providing	provide	VBG
cord-253501-hkxlq3os	208	19	treatment	treatment	NN
cord-253501-hkxlq3os	208	20	to	to	IN
cord-253501-hkxlq3os	208	21	poor	poor	JJ
cord-253501-hkxlq3os	208	22	responders	responder	NNS
cord-253501-hkxlq3os	208	23	to	to	IN
cord-253501-hkxlq3os	208	24	vaccines	vaccine	NNS
cord-253501-hkxlq3os	208	25	,	,	,
cord-253501-hkxlq3os	208	26	such	such	JJ
cord-253501-hkxlq3os	208	27	as	as	IN
cord-253501-hkxlq3os	208	28	immune	immune	NN
cord-253501-hkxlq3os	208	29	-	-	HYPH
cord-253501-hkxlq3os	208	30	compromised	compromise	VBN
cord-253501-hkxlq3os	208	31	patients	patient	NNS
cord-253501-hkxlq3os	208	32	,	,	,
cord-253501-hkxlq3os	208	33	warrants	warrant	VBZ
cord-253501-hkxlq3os	208	34	the	the	DT
cord-253501-hkxlq3os	208	35	need	need	NN
cord-253501-hkxlq3os	208	36	for	for	IN
cord-253501-hkxlq3os	208	37	development	development	NN
cord-253501-hkxlq3os	208	38	of	of	IN
cord-253501-hkxlq3os	208	39	specific	specific	JJ
cord-253501-hkxlq3os	208	40	drugs	drug	NNS
cord-253501-hkxlq3os	208	41	against	against	IN
cord-253501-hkxlq3os	208	42	HEV	HEV	NNP
cord-253501-hkxlq3os	208	43	.	.	.
cord-253501-hkxlq3os	209	1	The	the	DT
cord-253501-hkxlq3os	209	2	antivirals	antiviral	NNS
cord-253501-hkxlq3os	209	3	will	will	MD
cord-253501-hkxlq3os	209	4	also	also	RB
cord-253501-hkxlq3os	209	5	prove	prove	VB
cord-253501-hkxlq3os	209	6	to	to	TO
cord-253501-hkxlq3os	209	7	be	be	VB
cord-253501-hkxlq3os	209	8	useful	useful	JJ
cord-253501-hkxlq3os	209	9	for	for	IN
cord-253501-hkxlq3os	209	10	patients	patient	NNS
cord-253501-hkxlq3os	209	11	with	with	IN
cord-253501-hkxlq3os	209	12	acute	acute	JJ
cord-253501-hkxlq3os	209	13	,	,	,
cord-253501-hkxlq3os	209	14	chronic	chronic	JJ
cord-253501-hkxlq3os	209	15	or	or	CC
cord-253501-hkxlq3os	209	16	fulminant	fulminant	JJ
cord-253501-hkxlq3os	209	17	HEV	HEV	NNP
cord-253501-hkxlq3os	209	18	infections	infection	NNS
cord-253501-hkxlq3os	209	19	.	.	.
cord-253501-hkxlq3os	210	1	As	as	IN
cord-253501-hkxlq3os	210	2	summarized	summarize	VBN
cord-253501-hkxlq3os	210	3	in	in	IN
cord-253501-hkxlq3os	210	4	Table	Table	NNP
cord-253501-hkxlq3os	210	5	1	1	CD
cord-253501-hkxlq3os	210	6	and	and	CC
cord-253501-hkxlq3os	210	7	Fig	Fig	NNP
cord-253501-hkxlq3os	210	8	.	.	NNP
cord-253501-hkxlq3os	210	9	1	1	CD
cord-253501-hkxlq3os	210	10	,	,	,
cord-253501-hkxlq3os	210	11	a	a	DT
cord-253501-hkxlq3os	210	12	number	number	NN
cord-253501-hkxlq3os	210	13	of	of	IN
cord-253501-hkxlq3os	210	14	promising	promising	JJ
cord-253501-hkxlq3os	210	15	antiviral	antiviral	JJ
cord-253501-hkxlq3os	210	16	candidates	candidate	NNS
cord-253501-hkxlq3os	210	17	have	have	VBP
cord-253501-hkxlq3os	210	18	been	be	VBN
cord-253501-hkxlq3os	210	19	identified	identify	VBN
cord-253501-hkxlq3os	210	20	through	through	IN
cord-253501-hkxlq3os	210	21	the	the	DT
cord-253501-hkxlq3os	210	22	efforts	effort	NNS
cord-253501-hkxlq3os	210	23	of	of	IN
cord-253501-hkxlq3os	210	24	several	several	JJ
cord-253501-hkxlq3os	210	25	researchers	researcher	NNS
cord-253501-hkxlq3os	210	26	,	,	,
cord-253501-hkxlq3os	210	27	which	which	WDT
cord-253501-hkxlq3os	210	28	should	should	MD
cord-253501-hkxlq3os	210	29	be	be	VB
cord-253501-hkxlq3os	210	30	further	further	RB
cord-253501-hkxlq3os	210	31	characterized	characterize	VBN
cord-253501-hkxlq3os	210	32	to	to	TO
cord-253501-hkxlq3os	210	33	identify	identify	VB
cord-253501-hkxlq3os	210	34	one	one	CD
cord-253501-hkxlq3os	210	35	or	or	CC
cord-253501-hkxlq3os	210	36	more	more	RBR
cord-253501-hkxlq3os	210	37	potent	potent	JJ
cord-253501-hkxlq3os	210	38	inhibitor(s	inhibitor(s	NN
cord-253501-hkxlq3os	210	39	)	)	-RRB-
cord-253501-hkxlq3os	210	40	of	of	IN
cord-253501-hkxlq3os	210	41	HEV	HEV	NNP
cord-253501-hkxlq3os	210	42	.	.	.
cord-253501-hkxlq3os	211	1	A	a	DT
cord-253501-hkxlq3os	211	2	combinatorial	combinatorial	JJ
cord-253501-hkxlq3os	211	3	therapy	therapy	NN
cord-253501-hkxlq3os	211	4	targeting	target	VBG
cord-253501-hkxlq3os	211	5	crucial	crucial	JJ
cord-253501-hkxlq3os	211	6	virus	virus	NN
cord-253501-hkxlq3os	211	7	-	-	HYPH
cord-253501-hkxlq3os	211	8	encoded	encode	VBN
cord-253501-hkxlq3os	211	9	factors	factor	NNS
cord-253501-hkxlq3os	211	10	at	at	IN
cord-253501-hkxlq3os	211	11	different	different	JJ
cord-253501-hkxlq3os	211	12	stages	stage	NNS
cord-253501-hkxlq3os	211	13	of	of	IN
cord-253501-hkxlq3os	211	14	viral	viral	JJ
cord-253501-hkxlq3os	211	15	life	life	NN
cord-253501-hkxlq3os	211	16	cycle	cycle	NN
cord-253501-hkxlq3os	211	17	as	as	RB
cord-253501-hkxlq3os	211	18	well	well	RB
cord-253501-hkxlq3os	211	19	as	as	IN
cord-253501-hkxlq3os	211	20	inhibition	inhibition	NN
cord-253501-hkxlq3os	211	21	of	of	IN
cord-253501-hkxlq3os	211	22	virus	virus	NN
cord-253501-hkxlq3os	211	23	-	-	HYPH
cord-253501-hkxlq3os	211	24	host	host	NN
cord-253501-hkxlq3os	211	25	interactions	interaction	NNS
cord-253501-hkxlq3os	211	26	should	should	MD
cord-253501-hkxlq3os	211	27	be	be	VB
cord-253501-hkxlq3os	211	28	a	a	DT
cord-253501-hkxlq3os	211	29	potent	potent	JJ
cord-253501-hkxlq3os	211	30	antiviral	antiviral	JJ
cord-253501-hkxlq3os	211	31	strategy	strategy	NN
cord-253501-hkxlq3os	211	32	against	against	IN
cord-253501-hkxlq3os	211	33	HEV	HEV	NNP
cord-253501-hkxlq3os	211	34	.	.	.
cord-253501-hkxlq3os	212	1	The	the	DT
cord-253501-hkxlq3os	212	2	recent	recent	JJ
cord-253501-hkxlq3os	212	3	finding	finding	NN
cord-253501-hkxlq3os	212	4	of	of	IN
cord-253501-hkxlq3os	212	5	HEV	HEV	NNP
cord-253501-hkxlq3os	212	6	inhibitory	inhibitory	JJ
cord-253501-hkxlq3os	212	7	activity	activity	NN
cord-253501-hkxlq3os	212	8	of	of	IN
cord-253501-hkxlq3os	212	9	zinc	zinc	NN
cord-253501-hkxlq3os	212	10	also	also	RB
cord-253501-hkxlq3os	212	11	appears	appear	VBZ
cord-253501-hkxlq3os	212	12	to	to	TO
cord-253501-hkxlq3os	212	13	be	be	VB
cord-253501-hkxlq3os	212	14	an	an	DT
cord-253501-hkxlq3os	212	15	attractive	attractive	JJ
cord-253501-hkxlq3os	212	16	area	area	NN
cord-253501-hkxlq3os	212	17	for	for	IN
cord-253501-hkxlq3os	212	18	further	further	JJ
cord-253501-hkxlq3os	212	19	investigation	investigation	NN
cord-253501-hkxlq3os	212	20	.	.	.
cord-253501-hkxlq3os	213	1	Zinc	zinc	NN
cord-253501-hkxlq3os	213	2	directly	directly	RB
cord-253501-hkxlq3os	213	3	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	213	4	HEV	HEV	NNP
cord-253501-hkxlq3os	213	5	RNA	RNA	NNP
cord-253501-hkxlq3os	213	6	-	-	HYPH
cord-253501-hkxlq3os	213	7	dependent	dependent	JJ
cord-253501-hkxlq3os	213	8	RNA	RNA	NNP
cord-253501-hkxlq3os	213	9	polymerase	polymerase	NN
cord-253501-hkxlq3os	213	10	activity	activity	NN
cord-253501-hkxlq3os	213	11	in	in	IN
cord-253501-hkxlq3os	213	12	vitro	vitro	FW
cord-253501-hkxlq3os	213	13	and	and	CC
cord-253501-hkxlq3os	213	14	displays	display	VBZ
cord-253501-hkxlq3os	213	15	moderate	moderate	JJ
cord-253501-hkxlq3os	213	16	cooperativity	cooperativity	NN
cord-253501-hkxlq3os	213	17	with	with	IN
cord-253501-hkxlq3os	213	18	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	213	19	in	in	IN
cord-253501-hkxlq3os	213	20	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	213	21	viral	viral	JJ
cord-253501-hkxlq3os	213	22	replication	replication	NN
cord-253501-hkxlq3os	213	23	in	in	IN
cord-253501-hkxlq3os	213	24	mammalian	mammalian	JJ
cord-253501-hkxlq3os	213	25	cell	cell	NN
cord-253501-hkxlq3os	213	26	culture	culture	NN
cord-253501-hkxlq3os	213	27	models	model	NNS
cord-253501-hkxlq3os	213	28	of	of	IN
cord-253501-hkxlq3os	213	29	HEV	HEV	NNP
cord-253501-hkxlq3os	213	30	infection	infection	NN
cord-253501-hkxlq3os	213	31	.	.	.
cord-253501-hkxlq3os	214	1	Therefore	therefore	RB
cord-253501-hkxlq3os	214	2	,	,	,
cord-253501-hkxlq3os	214	3	even	even	RB
cord-253501-hkxlq3os	214	4	a	a	DT
cord-253501-hkxlq3os	214	5	moderate	moderate	JJ
cord-253501-hkxlq3os	214	6	increase	increase	NN
cord-253501-hkxlq3os	214	7	in	in	IN
cord-253501-hkxlq3os	214	8	the	the	DT
cord-253501-hkxlq3os	214	9	level	level	NN
cord-253501-hkxlq3os	214	10	of	of	IN
cord-253501-hkxlq3os	214	11	bioavailable	bioavailable	JJ
cord-253501-hkxlq3os	214	12	zinc	zinc	NN
cord-253501-hkxlq3os	214	13	may	may	MD
cord-253501-hkxlq3os	214	14	significantly	significantly	RB
cord-253501-hkxlq3os	214	15	improve	improve	VB
cord-253501-hkxlq3os	214	16	the	the	DT
cord-253501-hkxlq3os	214	17	therapeutic	therapeutic	JJ
cord-253501-hkxlq3os	214	18	benefits	benefit	NNS
cord-253501-hkxlq3os	214	19	when	when	WRB
cord-253501-hkxlq3os	214	20	combined	combine	VBN
cord-253501-hkxlq3os	214	21	with	with	IN
cord-253501-hkxlq3os	214	22	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	214	23	therapy	therapy	NN
cord-253501-hkxlq3os	214	24	.	.	.
cord-253501-hkxlq3os	215	1	In	in	IN
cord-253501-hkxlq3os	215	2	summary	summary	NN
cord-253501-hkxlq3os	215	3	,	,	,
cord-253501-hkxlq3os	215	4	recent	recent	JJ
cord-253501-hkxlq3os	215	5	studies	study	NNS
cord-253501-hkxlq3os	215	6	have	have	VBP
cord-253501-hkxlq3os	215	7	identified	identify	VBN
cord-253501-hkxlq3os	215	8	multiple	multiple	JJ
cord-253501-hkxlq3os	215	9	leads	lead	NNS
cord-253501-hkxlq3os	215	10	,	,	,
cord-253501-hkxlq3os	215	11	which	which	WDT
cord-253501-hkxlq3os	215	12	should	should	MD
cord-253501-hkxlq3os	215	13	be	be	VB
cord-253501-hkxlq3os	215	14	pursued	pursue	VBN
cord-253501-hkxlq3os	215	15	further	far	RBR
cord-253501-hkxlq3os	215	16	to	to	TO
cord-253501-hkxlq3os	215	17	develop	develop	VB
cord-253501-hkxlq3os	215	18	a	a	DT
cord-253501-hkxlq3os	215	19	potent	potent	JJ
cord-253501-hkxlq3os	215	20	antiviral	antiviral	JJ
cord-253501-hkxlq3os	215	21	against	against	IN
cord-253501-hkxlq3os	215	22	HEV	HEV	NNP
cord-253501-hkxlq3os	215	23	.	.	.
cord-253501-hkxlq3os	216	1	The	the	DT
cord-253501-hkxlq3os	216	2	DBT	DBT	NNP
cord-253501-hkxlq3os	216	3	-	-	HYPH
cord-253501-hkxlq3os	216	4	RGYI	RGYI	NNP
cord-253501-hkxlq3os	216	5	grant	grant	NN
cord-253501-hkxlq3os	216	6	and	and	CC
cord-253501-hkxlq3os	216	7	Ramalingswamy	Ramalingswamy	NNP
cord-253501-hkxlq3os	216	8	fellowship	fellowship	NN
cord-253501-hkxlq3os	216	9	to	to	IN
cord-253501-hkxlq3os	216	10	MS	MS	NNP
cord-253501-hkxlq3os	216	11	is	be	VBZ
cord-253501-hkxlq3os	216	12	gratefully	gratefully	RB
cord-253501-hkxlq3os	216	13	acknowledged	acknowledge	VBN
cord-253501-hkxlq3os	216	14	.	.	.
cord-253501-hkxlq3os	217	1	SA	SA	NNP
cord-253501-hkxlq3os	217	2	and	and	CC
cord-253501-hkxlq3os	217	3	NK	NK	NNP
cord-253501-hkxlq3os	217	4	are	be	VBP
cord-253501-hkxlq3os	217	5	supported	support	VBN
cord-253501-hkxlq3os	217	6	by	by	IN
cord-253501-hkxlq3os	217	7	senior	senior	JJ
cord-253501-hkxlq3os	217	8	research	research	NN
cord-253501-hkxlq3os	217	9	fellowships	fellowship	NNS
cord-253501-hkxlq3os	217	10	from	from	IN
cord-253501-hkxlq3os	217	11	the	the	DT
cord-253501-hkxlq3os	217	12	Department	Department	NNP
cord-253501-hkxlq3os	217	13	of	of	IN
cord-253501-hkxlq3os	217	14	Science	Science	NNP
cord-253501-hkxlq3os	217	15	&	&	CC
cord-253501-hkxlq3os	217	16	Technology	Technology	NNP
cord-253501-hkxlq3os	217	17	and	and	CC
cord-253501-hkxlq3os	217	18	the	the	DT
cord-253501-hkxlq3os	217	19	University	University	NNP
cord-253501-hkxlq3os	217	20	Grants	Grants	NNPS
cord-253501-hkxlq3os	217	21	Commission	Commission	NNP
cord-253501-hkxlq3os	217	22	,	,	,
cord-253501-hkxlq3os	217	23	Government	Government	NNP
cord-253501-hkxlq3os	217	24	of	of	IN
cord-253501-hkxlq3os	217	25	India	India	NNP
cord-253501-hkxlq3os	217	26	,	,	,
cord-253501-hkxlq3os	217	27	respectively	respectively	RB
cord-253501-hkxlq3os	217	28	.	.	.
cord-253501-hkxlq3os	218	1	The	the	DT
cord-253501-hkxlq3os	218	2	authors	author	NNS
cord-253501-hkxlq3os	218	3	have	have	VBP
cord-253501-hkxlq3os	218	4	no	no	DT
cord-253501-hkxlq3os	218	5	conflict	conflict	NN
cord-253501-hkxlq3os	218	6	of	of	IN
cord-253501-hkxlq3os	218	7	interests	interest	NNS
cord-253501-hkxlq3os	218	8	related	relate	VBN
cord-253501-hkxlq3os	218	9	to	to	IN
cord-253501-hkxlq3os	218	10	this	this	DT
cord-253501-hkxlq3os	218	11	publication	publication	NN
cord-253501-hkxlq3os	218	12	.	.	.
cord-253501-hkxlq3os	219	1	Wrote	write	VBD
cord-253501-hkxlq3os	219	2	all	all	DT
cord-253501-hkxlq3os	219	3	sections	section	NNS
cord-253501-hkxlq3os	219	4	of	of	IN
cord-253501-hkxlq3os	219	5	the	the	DT
cord-253501-hkxlq3os	219	6	manuscript	manuscript	NN
cord-253501-hkxlq3os	219	7	except	except	IN
cord-253501-hkxlq3os	219	8	the	the	DT
cord-253501-hkxlq3os	219	9	zinc	zinc	NN
cord-253501-hkxlq3os	219	10	section	section	NN
cord-253501-hkxlq3os	219	11	,	,	,
cord-253501-hkxlq3os	219	12	and	and	CC
cord-253501-hkxlq3os	219	13	generated	generate	VBD
cord-253501-hkxlq3os	219	14	the	the	DT
cord-253501-hkxlq3os	219	15	figure	figure	NN
cord-253501-hkxlq3os	219	16	and	and	CC
cord-253501-hkxlq3os	219	17	the	the	DT
cord-253501-hkxlq3os	219	18	table	table	NN
cord-253501-hkxlq3os	219	19	(	(	-LRB-
cord-253501-hkxlq3os	219	20	SA	SA	NNP
cord-253501-hkxlq3os	219	21	)	)	-RRB-
cord-253501-hkxlq3os	219	22	,	,	,
cord-253501-hkxlq3os	219	23	wrote	write	VBD
cord-253501-hkxlq3os	219	24	the	the	DT
cord-253501-hkxlq3os	219	25	zinc	zinc	NN
cord-253501-hkxlq3os	219	26	section	section	NN
cord-253501-hkxlq3os	219	27	of	of	IN
cord-253501-hkxlq3os	219	28	the	the	DT
cord-253501-hkxlq3os	219	29	manuscript	manuscript	NN
cord-253501-hkxlq3os	219	30	(	(	-LRB-
cord-253501-hkxlq3os	219	31	NK	NK	NNP
cord-253501-hkxlq3os	219	32	)	)	-RRB-
cord-253501-hkxlq3os	219	33	,	,	,
cord-253501-hkxlq3os	219	34	edited	edit	VBD
cord-253501-hkxlq3os	219	35	the	the	DT
cord-253501-hkxlq3os	219	36	manuscript	manuscript	NN
cord-253501-hkxlq3os	219	37	(	(	-LRB-
cord-253501-hkxlq3os	219	38	MS	MS	NNP
cord-253501-hkxlq3os	219	39	)	)	-RRB-
cord-253501-hkxlq3os	219	40	.	.	.
cord-253501-hkxlq3os	220	1	All	all	DT
cord-253501-hkxlq3os	220	2	authors	author	NNS
cord-253501-hkxlq3os	220	3	read	read	VBP
cord-253501-hkxlq3os	220	4	and	and	CC
cord-253501-hkxlq3os	220	5	approved	approve	VBD
cord-253501-hkxlq3os	220	6	the	the	DT
cord-253501-hkxlq3os	220	7	manuscript	manuscript	NN
cord-253501-hkxlq3os	220	8	.	.	.
cord-253501-hkxlq3os	220	9	 	 	_SP
cord-253501-hkxlq3os	221	1	Molecular	molecular	JJ
cord-253501-hkxlq3os	221	2	virology	virology	NN
cord-253501-hkxlq3os	221	3	of	of	IN
cord-253501-hkxlq3os	221	4	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	221	5	E	E	NNP
cord-253501-hkxlq3os	221	6	virus	virus	NN
cord-253501-hkxlq3os	221	7	Transfusiontransmitted	transfusiontransmitte	VBN
cord-253501-hkxlq3os	221	8	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	221	9	E	E	NNP
cord-253501-hkxlq3os	221	10	in	in	IN
cord-253501-hkxlq3os	221	11	a	a	DT
cord-253501-hkxlq3os	221	12	patient	patient	NN
cord-253501-hkxlq3os	221	13	with	with	IN
cord-253501-hkxlq3os	221	14	myelodysplastic	myelodysplastic	JJ
cord-253501-hkxlq3os	221	15	syndromes	syndrome	NNS
cord-253501-hkxlq3os	222	1	A	a	DT
cord-253501-hkxlq3os	222	2	case	case	NN
cord-253501-hkxlq3os	222	3	of	of	IN
cord-253501-hkxlq3os	222	4	transfusion	transfusion	NN
cord-253501-hkxlq3os	222	5	-	-	HYPH
cord-253501-hkxlq3os	222	6	transmitted	transmit	VBN
cord-253501-hkxlq3os	222	7	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	8	E	e	NN
cord-253501-hkxlq3os	222	9	caused	cause	VBN
cord-253501-hkxlq3os	222	10	by	by	IN
cord-253501-hkxlq3os	222	11	blood	blood	NN
cord-253501-hkxlq3os	222	12	from	from	IN
cord-253501-hkxlq3os	222	13	a	a	DT
cord-253501-hkxlq3os	222	14	donor	donor	NN
cord-253501-hkxlq3os	222	15	infected	infect	VBN
cord-253501-hkxlq3os	222	16	with	with	IN
cord-253501-hkxlq3os	222	17	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	18	E	e	NN
cord-253501-hkxlq3os	222	19	virus	virus	NN
cord-253501-hkxlq3os	222	20	via	via	IN
cord-253501-hkxlq3os	222	21	zoonotic	zoonotic	JJ
cord-253501-hkxlq3os	222	22	food	food	NN
cord-253501-hkxlq3os	222	23	-	-	HYPH
cord-253501-hkxlq3os	222	24	borne	bear	VBN
cord-253501-hkxlq3os	222	25	route	route	NN
cord-253501-hkxlq3os	222	26	Fetal	fetal	JJ
cord-253501-hkxlq3os	222	27	and	and	CC
cord-253501-hkxlq3os	222	28	neonatal	neonatal	JJ
cord-253501-hkxlq3os	222	29	health	health	NN
cord-253501-hkxlq3os	222	30	consequences	consequence	NNS
cord-253501-hkxlq3os	222	31	of	of	IN
cord-253501-hkxlq3os	222	32	vertically	vertically	RB
cord-253501-hkxlq3os	222	33	transmitted	transmit	VBN
cord-253501-hkxlq3os	222	34	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	35	E	e	NN
cord-253501-hkxlq3os	222	36	virus	virus	NN
cord-253501-hkxlq3os	222	37	infection	infection	NN
cord-253501-hkxlq3os	222	38	Seroprevalence	seroprevalence	NN
cord-253501-hkxlq3os	222	39	and	and	CC
cord-253501-hkxlq3os	222	40	mother	mother	NN
cord-253501-hkxlq3os	222	41	-	-	HYPH
cord-253501-hkxlq3os	222	42	to	to	IN
cord-253501-hkxlq3os	222	43	-	-	HYPH
cord-253501-hkxlq3os	222	44	infant	infant	NN
cord-253501-hkxlq3os	222	45	transmission	transmission	NN
cord-253501-hkxlq3os	222	46	of	of	IN
cord-253501-hkxlq3os	222	47	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	48	E	e	NN
cord-253501-hkxlq3os	222	49	virus	virus	NN
cord-253501-hkxlq3os	222	50	among	among	IN
cord-253501-hkxlq3os	222	51	pregnant	pregnant	JJ
cord-253501-hkxlq3os	222	52	women	woman	NNS
cord-253501-hkxlq3os	222	53	in	in	IN
cord-253501-hkxlq3os	222	54	the	the	DT
cord-253501-hkxlq3os	222	55	United	United	NNP
cord-253501-hkxlq3os	222	56	Arab	Arab	NNP
cord-253501-hkxlq3os	222	57	Emirates	Emirates	NNP
cord-253501-hkxlq3os	222	58	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	222	59	E	E	NNP
cord-253501-hkxlq3os	222	60	in	in	IN
cord-253501-hkxlq3os	222	61	pregnancy	pregnancy	NN
cord-253501-hkxlq3os	222	62	Clinical	clinical	JJ
cord-253501-hkxlq3os	222	63	course	course	NN
cord-253501-hkxlq3os	222	64	and	and	CC
cord-253501-hkxlq3os	222	65	duration	duration	NN
cord-253501-hkxlq3os	222	66	of	of	IN
cord-253501-hkxlq3os	222	67	viremia	viremia	NN
cord-253501-hkxlq3os	222	68	in	in	IN
cord-253501-hkxlq3os	222	69	vertically	vertically	RB
cord-253501-hkxlq3os	222	70	transmitted	transmit	VBN
cord-253501-hkxlq3os	222	71	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	72	E	e	NN
cord-253501-hkxlq3os	222	73	virus	virus	NN
cord-253501-hkxlq3os	222	74	(	(	-LRB-
cord-253501-hkxlq3os	222	75	HEV	hev	NN
cord-253501-hkxlq3os	222	76	)	)	-RRB-
cord-253501-hkxlq3os	222	77	infection	infection	NN
cord-253501-hkxlq3os	222	78	in	in	IN
cord-253501-hkxlq3os	222	79	babies	baby	NNS
cord-253501-hkxlq3os	222	80	born	bear	VBN
cord-253501-hkxlq3os	222	81	to	to	IN
cord-253501-hkxlq3os	222	82	HEVinfected	hevinfecte	VBN
cord-253501-hkxlq3os	222	83	mothers	mother	NNS
cord-253501-hkxlq3os	222	84	Expanding	expand	VBG
cord-253501-hkxlq3os	222	85	host	host	NN
cord-253501-hkxlq3os	222	86	range	range	NN
cord-253501-hkxlq3os	222	87	and	and	CC
cord-253501-hkxlq3os	222	88	cross	cross	NN
cord-253501-hkxlq3os	222	89	-	-	JJ
cord-253501-hkxlq3os	222	90	species	species	JJ
cord-253501-hkxlq3os	222	91	infection	infection	NN
cord-253501-hkxlq3os	222	92	of	of	IN
cord-253501-hkxlq3os	222	93	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	94	E	e	NN
cord-253501-hkxlq3os	222	95	virus	virus	NN
cord-253501-hkxlq3os	222	96	Hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	97	E	E	NNP
cord-253501-hkxlq3os	222	98	virus	virus	NN
cord-253501-hkxlq3os	222	99	and	and	CC
cord-253501-hkxlq3os	222	100	chronic	chronic	JJ
cord-253501-hkxlq3os	222	101	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	222	102	in	in	IN
cord-253501-hkxlq3os	222	103	organ	organ	NN
cord-253501-hkxlq3os	222	104	-	-	HYPH
cord-253501-hkxlq3os	222	105	transplant	transplant	NN
cord-253501-hkxlq3os	222	106	recipients	recipient	NNS
cord-253501-hkxlq3os	223	1	Hepatitis	hepatitis	NN
cord-253501-hkxlq3os	223	2	E	e	NN
cord-253501-hkxlq3os	223	3	-	-	HYPH
cord-253501-hkxlq3os	223	4	induced	induce	VBN
cord-253501-hkxlq3os	223	5	severe	severe	JJ
cord-253501-hkxlq3os	223	6	myositis	myositis	NN
cord-253501-hkxlq3os	223	7	Hepatitis	hepatitis	NN
cord-253501-hkxlq3os	223	8	E	E	NNP
cord-253501-hkxlq3os	223	9	virus	virus	NN
cord-253501-hkxlq3os	223	10	infection	infection	NN
cord-253501-hkxlq3os	223	11	in	in	IN
cord-253501-hkxlq3os	223	12	HIV	HIV	NNP
cord-253501-hkxlq3os	223	13	-	-	HYPH
cord-253501-hkxlq3os	223	14	infected	infect	VBN
cord-253501-hkxlq3os	223	15	persons	person	NNS
cord-253501-hkxlq3os	223	16	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	223	17	E	E	NNP
cord-253501-hkxlq3os	223	18	virus	virus	NN
cord-253501-hkxlq3os	223	19	infection	infection	NN
cord-253501-hkxlq3os	223	20	as	as	IN
cord-253501-hkxlq3os	223	21	a	a	DT
cord-253501-hkxlq3os	223	22	cause	cause	NN
cord-253501-hkxlq3os	223	23	of	of	IN
cord-253501-hkxlq3os	223	24	graft	graft	NN
cord-253501-hkxlq3os	223	25	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	223	26	in	in	IN
cord-253501-hkxlq3os	223	27	liver	liver	NN
cord-253501-hkxlq3os	223	28	transplant	transplant	NN
cord-253501-hkxlq3os	223	29	recipients	recipient	NNS
cord-253501-hkxlq3os	224	1	Chronic	chronic	JJ
cord-253501-hkxlq3os	224	2	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	224	3	e	e	NN
cord-253501-hkxlq3os	224	4	in	in	IN
cord-253501-hkxlq3os	224	5	heart	heart	NN
cord-253501-hkxlq3os	224	6	transplant	transplant	NN
cord-253501-hkxlq3os	224	7	recipients	recipient	NNS
cord-253501-hkxlq3os	224	8	Chronic	Chronic	NNP
cord-253501-hkxlq3os	224	9	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	224	10	E	e	NN
cord-253501-hkxlq3os	224	11	infection	infection	NN
cord-253501-hkxlq3os	224	12	in	in	IN
cord-253501-hkxlq3os	224	13	a	a	DT
cord-253501-hkxlq3os	224	14	persistently	persistently	RB
cord-253501-hkxlq3os	224	15	immunosuppressed	immunosuppressed	JJ
cord-253501-hkxlq3os	224	16	patient	patient	NN
cord-253501-hkxlq3os	224	17	unable	unable	JJ
cord-253501-hkxlq3os	224	18	to	to	TO
cord-253501-hkxlq3os	224	19	be	be	VB
cord-253501-hkxlq3os	224	20	eliminated	eliminate	VBN
cord-253501-hkxlq3os	224	21	after	after	IN
cord-253501-hkxlq3os	224	22	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	224	23	therapy	therapy	NN
cord-253501-hkxlq3os	224	24	Incidence	incidence	NN
cord-253501-hkxlq3os	224	25	and	and	CC
cord-253501-hkxlq3os	224	26	severity	severity	NN
cord-253501-hkxlq3os	224	27	of	of	IN
cord-253501-hkxlq3os	224	28	viral	viral	JJ
cord-253501-hkxlq3os	224	29	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	224	30	in	in	IN
cord-253501-hkxlq3os	224	31	pregnancy	pregnancy	NN
cord-253501-hkxlq3os	224	32	Outcome	outcome	NN
cord-253501-hkxlq3os	224	33	of	of	IN
cord-253501-hkxlq3os	224	34	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	224	35	E	e	NN
cord-253501-hkxlq3os	224	36	virus	virus	NN
cord-253501-hkxlq3os	224	37	infection	infection	NN
cord-253501-hkxlq3os	224	38	in	in	IN
cord-253501-hkxlq3os	224	39	Indian	indian	JJ
cord-253501-hkxlq3os	224	40	pregnant	pregnant	JJ
cord-253501-hkxlq3os	224	41	women	woman	NNS
cord-253501-hkxlq3os	224	42	admitted	admit	VBD
cord-253501-hkxlq3os	224	43	to	to	IN
cord-253501-hkxlq3os	224	44	a	a	DT
cord-253501-hkxlq3os	224	45	tertiary	tertiary	JJ
cord-253501-hkxlq3os	224	46	care	care	NN
cord-253501-hkxlq3os	224	47	hospital	hospital	NN
cord-253501-hkxlq3os	224	48	HEV	hev	NN
cord-253501-hkxlq3os	224	49	-	-	HYPH
cord-253501-hkxlq3os	224	50	associated	associate	VBN
cord-253501-hkxlq3os	224	51	cryoglobulinaemia	cryoglobulinaemia	NN
cord-253501-hkxlq3os	224	52	and	and	CC
cord-253501-hkxlq3os	224	53	extrahepatic	extrahepatic	JJ
cord-253501-hkxlq3os	224	54	manifestations	manifestation	NNS
cord-253501-hkxlq3os	224	55	of	of	IN
cord-253501-hkxlq3os	224	56	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	224	57	E	E	NNP
cord-253501-hkxlq3os	224	58	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	224	59	E	e	NN
cord-253501-hkxlq3os	224	60	virus	virus	NN
cord-253501-hkxlq3os	224	61	infection	infection	NN
cord-253501-hkxlq3os	224	62	and	and	CC
cord-253501-hkxlq3os	224	63	acute	acute	JJ
cord-253501-hkxlq3os	224	64	non	non	JJ
cord-253501-hkxlq3os	224	65	-	-	JJ
cord-253501-hkxlq3os	224	66	traumatic	traumatic	JJ
cord-253501-hkxlq3os	224	67	neurological	neurological	JJ
cord-253501-hkxlq3os	224	68	injury	injury	NN
cord-253501-hkxlq3os	224	69	:	:	:
cord-253501-hkxlq3os	225	1	A	a	DT
cord-253501-hkxlq3os	225	2	prospective	prospective	JJ
cord-253501-hkxlq3os	225	3	multicentre	multicentre	NN
cord-253501-hkxlq3os	225	4	study	study	NN
cord-253501-hkxlq3os	225	5	Rash	Rash	NNP
cord-253501-hkxlq3os	225	6	and	and	CC
cord-253501-hkxlq3os	225	7	arthralgia	arthralgia	NNP
cord-253501-hkxlq3os	225	8	caused	cause	VBN
cord-253501-hkxlq3os	225	9	by	by	IN
cord-253501-hkxlq3os	225	10	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	225	11	E	E	NNP
cord-253501-hkxlq3os	225	12	Extrahepatic	Extrahepatic	NNP
cord-253501-hkxlq3os	225	13	replication	replication	NN
cord-253501-hkxlq3os	225	14	and	and	CC
cord-253501-hkxlq3os	225	15	infection	infection	NN
cord-253501-hkxlq3os	225	16	of	of	IN
cord-253501-hkxlq3os	225	17	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	225	18	E	e	NN
cord-253501-hkxlq3os	225	19	virus	virus	NN
cord-253501-hkxlq3os	225	20	in	in	IN
cord-253501-hkxlq3os	225	21	neuronal	neuronal	JJ
cord-253501-hkxlq3os	225	22	-	-	HYPH
cord-253501-hkxlq3os	225	23	derived	derive	VBN
cord-253501-hkxlq3os	225	24	cells	cell	NNS
cord-253501-hkxlq3os	226	1	The	the	DT
cord-253501-hkxlq3os	226	2	global	global	JJ
cord-253501-hkxlq3os	226	3	burden	burden	NN
cord-253501-hkxlq3os	226	4	of	of	IN
cord-253501-hkxlq3os	226	5	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	226	6	E	e	NN
cord-253501-hkxlq3os	226	7	virus	virus	NN
cord-253501-hkxlq3os	226	8	genotypes	genotype	NNS
cord-253501-hkxlq3os	226	9	1	1	CD
cord-253501-hkxlq3os	226	10	and	and	CC
cord-253501-hkxlq3os	226	11	2	2	CD
cord-253501-hkxlq3os	226	12	in	in	IN
cord-253501-hkxlq3os	226	13	2005	2005	CD
cord-253501-hkxlq3os	227	1	An	an	DT
cord-253501-hkxlq3os	227	2	outbreak	outbreak	NN
cord-253501-hkxlq3os	227	3	of	of	IN
cord-253501-hkxlq3os	227	4	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	227	5	E	e	NN
cord-253501-hkxlq3os	227	6	virus	virus	NN
cord-253501-hkxlq3os	227	7	in	in	IN
cord-253501-hkxlq3os	227	8	Raipur	Raipur	NNP
cord-253501-hkxlq3os	227	9	,	,	,
cord-253501-hkxlq3os	227	10	Chhattisgarh	Chhattisgarh	NNP
cord-253501-hkxlq3os	227	11	,	,	,
cord-253501-hkxlq3os	227	12	India	India	NNP
cord-253501-hkxlq3os	227	13	in	in	IN
cord-253501-hkxlq3os	227	14	2014	2014	CD
cord-253501-hkxlq3os	227	15	:	:	:
cord-253501-hkxlq3os	227	16	A	a	DT
cord-253501-hkxlq3os	227	17	conventional	conventional	JJ
cord-253501-hkxlq3os	227	18	and	and	CC
cord-253501-hkxlq3os	227	19	genetic	genetic	JJ
cord-253501-hkxlq3os	227	20	analysis	analysis	NN
cord-253501-hkxlq3os	227	21	Epidemic	epidemic	NN
cord-253501-hkxlq3os	227	22	investigation	investigation	NN
cord-253501-hkxlq3os	227	23	of	of	IN
cord-253501-hkxlq3os	227	24	the	the	DT
cord-253501-hkxlq3os	227	25	jaundice	jaundice	NN
cord-253501-hkxlq3os	227	26	outbreak	outbreak	NN
cord-253501-hkxlq3os	227	27	in	in	IN
cord-253501-hkxlq3os	227	28	girdharnagar	girdharnagar	NNP
cord-253501-hkxlq3os	227	29	Investigation	Investigation	NNP
cord-253501-hkxlq3os	227	30	of	of	IN
cord-253501-hkxlq3os	227	31	an	an	DT
cord-253501-hkxlq3os	227	32	epidemic	epidemic	NN
cord-253501-hkxlq3os	227	33	of	of	IN
cord-253501-hkxlq3os	227	34	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	227	35	E	E	NNP
cord-253501-hkxlq3os	227	36	in	in	IN
cord-253501-hkxlq3os	227	37	Nellore	Nellore	NNP
cord-253501-hkxlq3os	227	38	in	in	IN
cord-253501-hkxlq3os	227	39	south	south	JJ
cord-253501-hkxlq3os	227	40	India	India	NNP
cord-253501-hkxlq3os	227	41	Investigation	Investigation	NNP
cord-253501-hkxlq3os	227	42	of	of	IN
cord-253501-hkxlq3os	227	43	an	an	DT
cord-253501-hkxlq3os	227	44	outbreak	outbreak	NN
cord-253501-hkxlq3os	227	45	of	of	IN
cord-253501-hkxlq3os	227	46	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	227	47	'	'	``
cord-253501-hkxlq3os	227	48	E	E	NNP
cord-253501-hkxlq3os	227	49	'	'	''
cord-253501-hkxlq3os	227	50	in	in	IN
cord-253501-hkxlq3os	227	51	a	a	DT
cord-253501-hkxlq3os	227	52	rural	rural	JJ
cord-253501-hkxlq3os	227	53	area	area	NN
cord-253501-hkxlq3os	227	54	of	of	IN
cord-253501-hkxlq3os	227	55	Dhule	Dhule	NNP
cord-253501-hkxlq3os	227	56	district	district	NN
cord-253501-hkxlq3os	227	57	in	in	IN
cord-253501-hkxlq3os	227	58	Maharashtra	Maharashtra	NNP
cord-253501-hkxlq3os	228	1	A	a	DT
cord-253501-hkxlq3os	228	2	systematic	systematic	JJ
cord-253501-hkxlq3os	228	3	review	review	NN
cord-253501-hkxlq3os	228	4	of	of	IN
cord-253501-hkxlq3os	228	5	the	the	DT
cord-253501-hkxlq3os	228	6	epidemiology	epidemiology	NN
cord-253501-hkxlq3os	228	7	of	of	IN
cord-253501-hkxlq3os	228	8	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	228	9	E	e	NN
cord-253501-hkxlq3os	228	10	virus	virus	NN
cord-253501-hkxlq3os	228	11	in	in	IN
cord-253501-hkxlq3os	228	12	Africa	Africa	NNP
cord-253501-hkxlq3os	228	13	First	first	RB
cord-253501-hkxlq3os	228	14	reported	report	VBD
cord-253501-hkxlq3os	228	15	outbreak	outbreak	NN
cord-253501-hkxlq3os	228	16	of	of	IN
cord-253501-hkxlq3os	228	17	locally	locally	RB
cord-253501-hkxlq3os	228	18	acquired	acquire	VBN
cord-253501-hkxlq3os	228	19	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	228	20	E	e	NN
cord-253501-hkxlq3os	228	21	virus	virus	NN
cord-253501-hkxlq3os	228	22	infection	infection	NN
cord-253501-hkxlq3os	228	23	in	in	IN
cord-253501-hkxlq3os	228	24	Australia	Australia	NNP
cord-253501-hkxlq3os	228	25	Factors	Factors	NNP
cord-253501-hkxlq3os	228	26	associated	associate	VBN
cord-253501-hkxlq3os	228	27	with	with	IN
cord-253501-hkxlq3os	228	28	chronic	chronic	JJ
cord-253501-hkxlq3os	228	29	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	228	30	in	in	IN
cord-253501-hkxlq3os	228	31	patients	patient	NNS
cord-253501-hkxlq3os	228	32	with	with	IN
cord-253501-hkxlq3os	228	33	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	228	34	E	e	NN
cord-253501-hkxlq3os	228	35	virus	virus	NN
cord-253501-hkxlq3os	228	36	infection	infection	NN
cord-253501-hkxlq3os	228	37	who	who	WP
cord-253501-hkxlq3os	228	38	have	have	VBP
cord-253501-hkxlq3os	228	39	received	receive	VBN
cord-253501-hkxlq3os	228	40	solid	solid	JJ
cord-253501-hkxlq3os	228	41	organ	organ	NN
cord-253501-hkxlq3os	228	42	transplants	transplant	NNS
cord-253501-hkxlq3os	228	43	Ribavirin	ribavirin	IN
cord-253501-hkxlq3os	228	44	therapy	therapy	NN
cord-253501-hkxlq3os	228	45	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	228	46	viral	viral	JJ
cord-253501-hkxlq3os	228	47	replication	replication	NN
cord-253501-hkxlq3os	228	48	on	on	IN
cord-253501-hkxlq3os	228	49	patients	patient	NNS
cord-253501-hkxlq3os	228	50	with	with	IN
cord-253501-hkxlq3os	228	51	chronic	chronic	JJ
cord-253501-hkxlq3os	228	52	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	228	53	e	e	NN
cord-253501-hkxlq3os	228	54	virus	virus	NN
cord-253501-hkxlq3os	228	55	infection	infection	NN
cord-253501-hkxlq3os	228	56	Brief	brief	JJ
cord-253501-hkxlq3os	228	57	communication	communication	NN
cord-253501-hkxlq3os	228	58	:	:	:
cord-253501-hkxlq3os	229	1	case	case	NN
cord-253501-hkxlq3os	229	2	reports	report	NNS
cord-253501-hkxlq3os	229	3	of	of	IN
cord-253501-hkxlq3os	229	4	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	229	5	treatment	treatment	NN
cord-253501-hkxlq3os	229	6	for	for	IN
cord-253501-hkxlq3os	229	7	chronic	chronic	JJ
cord-253501-hkxlq3os	229	8	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	229	9	E	e	NN
cord-253501-hkxlq3os	229	10	Ribavirin	ribavirin	NN
cord-253501-hkxlq3os	229	11	treatment	treatment	NN
cord-253501-hkxlq3os	229	12	of	of	IN
cord-253501-hkxlq3os	229	13	acute	acute	JJ
cord-253501-hkxlq3os	229	14	and	and	CC
cord-253501-hkxlq3os	229	15	chronic	chronic	JJ
cord-253501-hkxlq3os	229	16	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	229	17	E	e	NN
cord-253501-hkxlq3os	229	18	:	:	:
cord-253501-hkxlq3os	229	19	a	a	DT
cord-253501-hkxlq3os	229	20	single	single	JJ
cord-253501-hkxlq3os	229	21	-	-	HYPH
cord-253501-hkxlq3os	229	22	centre	centre	NN
cord-253501-hkxlq3os	229	23	experience	experience	NN
cord-253501-hkxlq3os	229	24	Treatment	treatment	NN
cord-253501-hkxlq3os	229	25	of	of	IN
cord-253501-hkxlq3os	229	26	severe	severe	JJ
cord-253501-hkxlq3os	229	27	acute	acute	JJ
cord-253501-hkxlq3os	229	28	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	229	29	E	e	NN
cord-253501-hkxlq3os	229	30	by	by	IN
cord-253501-hkxlq3os	229	31	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	230	1	Ribavirin	ribavirin	RB
cord-253501-hkxlq3os	230	2	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	230	3	in	in	IN
cord-253501-hkxlq3os	230	4	vitro	vitro	FW
cord-253501-hkxlq3os	230	5	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	230	6	E	e	NN
cord-253501-hkxlq3os	230	7	virus	virus	NN
cord-253501-hkxlq3os	230	8	replication	replication	NN
cord-253501-hkxlq3os	230	9	through	through	IN
cord-253501-hkxlq3os	230	10	depletion	depletion	NN
cord-253501-hkxlq3os	230	11	of	of	IN
cord-253501-hkxlq3os	230	12	cellular	cellular	JJ
cord-253501-hkxlq3os	230	13	GTP	GTP	NNP
cord-253501-hkxlq3os	230	14	pools	pool	NNS
cord-253501-hkxlq3os	230	15	and	and	CC
cord-253501-hkxlq3os	230	16	is	be	VBZ
cord-253501-hkxlq3os	230	17	moderately	moderately	RB
cord-253501-hkxlq3os	230	18	synergistic	synergistic	JJ
cord-253501-hkxlq3os	230	19	with	with	IN
cord-253501-hkxlq3os	230	20	alpha	alpha	NN
cord-253501-hkxlq3os	231	1	interferon	interferon	NNP
cord-253501-hkxlq3os	231	2	A	a	DT
cord-253501-hkxlq3os	231	3	mutation	mutation	NN
cord-253501-hkxlq3os	231	4	in	in	IN
cord-253501-hkxlq3os	231	5	the	the	DT
cord-253501-hkxlq3os	231	6	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	231	7	E	E	NNP
cord-253501-hkxlq3os	231	8	virus	virus	NN
cord-253501-hkxlq3os	231	9	RNA	rna	NN
cord-253501-hkxlq3os	231	10	polymerase	polymerase	NN
cord-253501-hkxlq3os	231	11	promotes	promote	VBZ
cord-253501-hkxlq3os	231	12	its	-PRON-	PRP$
cord-253501-hkxlq3os	231	13	replication	replication	NN
cord-253501-hkxlq3os	231	14	and	and	CC
cord-253501-hkxlq3os	231	15	associates	associate	NNS
cord-253501-hkxlq3os	231	16	with	with	IN
cord-253501-hkxlq3os	231	17	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	231	18	treatment	treatment	NN
cord-253501-hkxlq3os	231	19	failure	failure	NN
cord-253501-hkxlq3os	231	20	in	in	IN
cord-253501-hkxlq3os	231	21	organ	organ	NN
cord-253501-hkxlq3os	231	22	transplant	transplant	NN
cord-253501-hkxlq3os	231	23	recipients	recipient	NNS
cord-253501-hkxlq3os	231	24	Mutation	Mutation	NNP
cord-253501-hkxlq3os	231	25	in	in	IN
cord-253501-hkxlq3os	231	26	the	the	DT
cord-253501-hkxlq3os	231	27	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	231	28	E	e	NN
cord-253501-hkxlq3os	231	29	virus	virus	NN
cord-253501-hkxlq3os	231	30	polymerase	polymerase	NN
cord-253501-hkxlq3os	231	31	and	and	CC
cord-253501-hkxlq3os	231	32	outcome	outcome	NN
cord-253501-hkxlq3os	231	33	of	of	IN
cord-253501-hkxlq3os	231	34	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	231	35	therapy	therapy	NN
cord-253501-hkxlq3os	232	1	In	in	IN
cord-253501-hkxlq3os	232	2	vivo	vivo	NN
cord-253501-hkxlq3os	232	3	evidence	evidence	NN
cord-253501-hkxlq3os	232	4	for	for	IN
cord-253501-hkxlq3os	232	5	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	232	6	-	-	HYPH
cord-253501-hkxlq3os	232	7	induced	induce	VBN
cord-253501-hkxlq3os	232	8	mutagenesis	mutagenesis	NN
cord-253501-hkxlq3os	232	9	of	of	IN
cord-253501-hkxlq3os	232	10	the	the	DT
cord-253501-hkxlq3os	232	11	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	232	12	E	e	NN
cord-253501-hkxlq3os	232	13	virus	virus	NN
cord-253501-hkxlq3os	232	14	genome	genome	NN
cord-253501-hkxlq3os	232	15	Mutagenic	mutagenic	JJ
cord-253501-hkxlq3os	232	16	effects	effect	NNS
cord-253501-hkxlq3os	232	17	of	of	IN
cord-253501-hkxlq3os	232	18	ribavirin	ribavirin	NN
cord-253501-hkxlq3os	232	19	on	on	IN
cord-253501-hkxlq3os	232	20	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	232	21	E	e	NN
cord-253501-hkxlq3os	232	22	virus	virus	NN
cord-253501-hkxlq3os	232	23	-	-	HYPH
cord-253501-hkxlq3os	232	24	viral	viral	JJ
cord-253501-hkxlq3os	232	25	extinction	extinction	NN
cord-253501-hkxlq3os	232	26	versus	versus	IN
cord-253501-hkxlq3os	232	27	selection	selection	NN
cord-253501-hkxlq3os	232	28	of	of	IN
cord-253501-hkxlq3os	232	29	fitness	fitness	NN
cord-253501-hkxlq3os	232	30	-	-	HYPH
cord-253501-hkxlq3os	232	31	enhancing	enhance	VBG
cord-253501-hkxlq3os	232	32	mutations	mutation	NNS
cord-253501-hkxlq3os	233	1	Ribavirin	ribavirin	RB
cord-253501-hkxlq3os	233	2	at	at	IN
cord-253501-hkxlq3os	233	3	the	the	DT
cord-253501-hkxlq3os	233	4	era	era	NN
cord-253501-hkxlq3os	233	5	of	of	IN
cord-253501-hkxlq3os	233	6	novel	novel	JJ
cord-253501-hkxlq3os	233	7	direct	direct	JJ
cord-253501-hkxlq3os	233	8	antiviral	antiviral	JJ
cord-253501-hkxlq3os	233	9	agents	agent	NNS
cord-253501-hkxlq3os	233	10	for	for	IN
cord-253501-hkxlq3os	233	11	the	the	DT
cord-253501-hkxlq3os	233	12	treatment	treatment	NN
cord-253501-hkxlq3os	233	13	of	of	IN
cord-253501-hkxlq3os	233	14	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	233	15	C	C	NNP
cord-253501-hkxlq3os	233	16	virus	virus	NN
cord-253501-hkxlq3os	233	17	infection	infection	NN
cord-253501-hkxlq3os	233	18	:	:	:
cord-253501-hkxlq3os	233	19	relevance	relevance	NN
cord-253501-hkxlq3os	233	20	of	of	IN
cord-253501-hkxlq3os	233	21	pharmacological	pharmacological	JJ
cord-253501-hkxlq3os	233	22	monitoring	monitor	VBG
cord-253501-hkxlq3os	233	23	Three	three	CD
cord-253501-hkxlq3os	233	24	-	-	HYPH
cord-253501-hkxlq3os	233	25	month	month	NN
cord-253501-hkxlq3os	233	26	pegylated	pegylated	JJ
cord-253501-hkxlq3os	233	27	interferon	interferon	NN
cord-253501-hkxlq3os	233	28	-	-	HYPH
cord-253501-hkxlq3os	233	29	alpha-2a	alpha-2a	NNP
cord-253501-hkxlq3os	233	30	therapy	therapy	NN
cord-253501-hkxlq3os	233	31	for	for	IN
cord-253501-hkxlq3os	233	32	chronic	chronic	JJ
cord-253501-hkxlq3os	233	33	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	233	34	E	e	NN
cord-253501-hkxlq3os	233	35	virus	virus	NN
cord-253501-hkxlq3os	233	36	infection	infection	NN
cord-253501-hkxlq3os	233	37	in	in	IN
cord-253501-hkxlq3os	233	38	a	a	DT
cord-253501-hkxlq3os	233	39	haemodialysis	haemodialysis	NN
cord-253501-hkxlq3os	233	40	patient	patient	NN
cord-253501-hkxlq3os	233	41	P61	P61	NNP
cord-253501-hkxlq3os	233	42	Pegylated	Pegylated	NNP
cord-253501-hkxlq3os	233	43	interferon	interferon	NN
cord-253501-hkxlq3os	233	44	and	and	CC
cord-253501-hkxlq3os	233	45	ribavarin	ribavarin	NNP
cord-253501-hkxlq3os	233	46	combination	combination	NNP
cord-253501-hkxlq3os	233	47	therapy	therapy	NN
cord-253501-hkxlq3os	234	1	achieves	achieve	VBZ
cord-253501-hkxlq3os	234	2	hepatitis	hepatitis	NNP
cord-253501-hkxlq3os	234	3	E	e	NN
cord-253501-hkxlq3os	234	4	virus	virus	NN
cord-253501-hkxlq3os	234	5	clearance	clearance	NN
cord-253501-hkxlq3os	234	6	in	in	IN
cord-253501-hkxlq3os	234	7	chronic	chronic	JJ
cord-253501-hkxlq3os	234	8	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	234	9	E	e	NN
cord-253501-hkxlq3os	234	10	virus	virus	NN
cord-253501-hkxlq3os	234	11	/	/	SYM
cord-253501-hkxlq3os	234	12	human	human	JJ
cord-253501-hkxlq3os	234	13	immunodeficiency	immunodeficiency	NN
cord-253501-hkxlq3os	234	14	virus	virus	NN
cord-253501-hkxlq3os	234	15	co	co	NN
cord-253501-hkxlq3os	234	16	-	-	NN
cord-253501-hkxlq3os	234	17	infection	infection	JJ
cord-253501-hkxlq3os	234	18	Treatment	treatment	NN
cord-253501-hkxlq3os	234	19	of	of	IN
cord-253501-hkxlq3os	234	20	chronic	chronic	JJ
cord-253501-hkxlq3os	234	21	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	234	22	E	e	NN
cord-253501-hkxlq3os	234	23	in	in	IN
cord-253501-hkxlq3os	234	24	liver	liver	NN
cord-253501-hkxlq3os	234	25	transplant	transplant	NN
cord-253501-hkxlq3os	234	26	recipients	recipient	NNS
cord-253501-hkxlq3os	234	27	with	with	IN
cord-253501-hkxlq3os	234	28	pegylated	pegylated	JJ
cord-253501-hkxlq3os	234	29	interferon	interferon	NN
cord-253501-hkxlq3os	234	30	alpha-2b	alpha-2b	NNP
cord-253501-hkxlq3os	235	1	Chronic	chronic	JJ
cord-253501-hkxlq3os	235	2	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	235	3	E	e	NN
cord-253501-hkxlq3os	235	4	virus	virus	NN
cord-253501-hkxlq3os	235	5	infection	infection	NN
cord-253501-hkxlq3os	235	6	:	:	:
cord-253501-hkxlq3os	235	7	successful	successful	JJ
cord-253501-hkxlq3os	235	8	virologic	virologic	JJ
cord-253501-hkxlq3os	235	9	response	response	NN
cord-253501-hkxlq3os	235	10	to	to	IN
cord-253501-hkxlq3os	235	11	pegylated	pegylated	JJ
cord-253501-hkxlq3os	235	12	interferon	interferon	NN
cord-253501-hkxlq3os	235	13	-	-	HYPH
cord-253501-hkxlq3os	235	14	alpha	alpha	NN
cord-253501-hkxlq3os	235	15	therapy	therapy	NN
cord-253501-hkxlq3os	235	16	Antiviral	antiviral	JJ
cord-253501-hkxlq3os	235	17	activities	activity	NNS
cord-253501-hkxlq3os	235	18	of	of	IN
cord-253501-hkxlq3os	235	19	different	different	JJ
cord-253501-hkxlq3os	235	20	interferon	interferon	NN
cord-253501-hkxlq3os	235	21	types	type	NNS
cord-253501-hkxlq3os	235	22	and	and	CC
cord-253501-hkxlq3os	235	23	subtypes	subtype	NNS
cord-253501-hkxlq3os	235	24	against	against	IN
cord-253501-hkxlq3os	235	25	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	235	26	E	e	NN
cord-253501-hkxlq3os	235	27	virus	virus	NN
cord-253501-hkxlq3os	235	28	replication	replication	NN
cord-253501-hkxlq3os	235	29	Disparity	disparity	NN
cord-253501-hkxlq3os	235	30	of	of	IN
cord-253501-hkxlq3os	235	31	basal	basal	NN
cord-253501-hkxlq3os	235	32	and	and	CC
cord-253501-hkxlq3os	235	33	therapeutically	therapeutically	RB
cord-253501-hkxlq3os	235	34	activated	activate	VBN
cord-253501-hkxlq3os	235	35	interferon	interferon	NN
cord-253501-hkxlq3os	235	36	signalling	signal	VBG
cord-253501-hkxlq3os	235	37	in	in	IN
cord-253501-hkxlq3os	236	1	constraining	constrain	VBG
cord-253501-hkxlq3os	236	2	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	236	3	E	e	NN
cord-253501-hkxlq3os	236	4	virus	virus	NN
cord-253501-hkxlq3os	236	5	infection	infection	NN
cord-253501-hkxlq3os	236	6	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	236	7	E	E	NNP
cord-253501-hkxlq3os	236	8	virus	virus	NN
cord-253501-hkxlq3os	236	9	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	236	10	type	type	NN
cord-253501-hkxlq3os	236	11	I	-PRON-	PRP
cord-253501-hkxlq3os	237	1	interferon	interferon	NN
cord-253501-hkxlq3os	237	2	induction	induction	NN
cord-253501-hkxlq3os	237	3	by	by	IN
cord-253501-hkxlq3os	237	4	ORF1	ORF1	NNP
cord-253501-hkxlq3os	237	5	products	product	NNS
cord-253501-hkxlq3os	237	6	Suppression	Suppression	NNP
cord-253501-hkxlq3os	237	7	of	of	IN
cord-253501-hkxlq3os	237	8	interferon	interferon	NN
cord-253501-hkxlq3os	237	9	-	-	:
cord-253501-hkxlq3os	237	10	a	a	DT
cord-253501-hkxlq3os	237	11	signaling	signaling	NN
cord-253501-hkxlq3os	237	12	by	by	IN
cord-253501-hkxlq3os	237	13	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	237	14	E	e	NN
cord-253501-hkxlq3os	237	15	virus	virus	NN
cord-253501-hkxlq3os	238	1	The	the	DT
cord-253501-hkxlq3os	238	2	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	238	3	E	e	NN
cord-253501-hkxlq3os	238	4	virus	virus	NN
cord-253501-hkxlq3os	238	5	ORF3	ORF3	NNP
cord-253501-hkxlq3os	238	6	protein	protein	NN
cord-253501-hkxlq3os	238	7	modulates	modulate	VBZ
cord-253501-hkxlq3os	238	8	epidermal	epidermal	JJ
cord-253501-hkxlq3os	238	9	growth	growth	NN
cord-253501-hkxlq3os	238	10	factor	factor	NN
cord-253501-hkxlq3os	238	11	receptor	receptor	NN
cord-253501-hkxlq3os	238	12	trafficking	trafficking	NN
cord-253501-hkxlq3os	238	13	,	,	,
cord-253501-hkxlq3os	238	14	STAT3	STAT3	NNP
cord-253501-hkxlq3os	238	15	translocation	translocation	NN
cord-253501-hkxlq3os	238	16	,	,	,
cord-253501-hkxlq3os	238	17	and	and	CC
cord-253501-hkxlq3os	238	18	the	the	DT
cord-253501-hkxlq3os	238	19	acute	acute	JJ
cord-253501-hkxlq3os	238	20	-	-	HYPH
cord-253501-hkxlq3os	238	21	phase	phase	NN
cord-253501-hkxlq3os	238	22	response	response	NN
cord-253501-hkxlq3os	239	1	Neuropsychiatric	neuropsychiatric	JJ
cord-253501-hkxlq3os	239	2	adverse	adverse	JJ
cord-253501-hkxlq3os	239	3	effects	effect	NNS
cord-253501-hkxlq3os	239	4	of	of	IN
cord-253501-hkxlq3os	239	5	interferon	interferon	NN
cord-253501-hkxlq3os	239	6	-	-	HYPH
cord-253501-hkxlq3os	239	7	alpha	alpha	NN
cord-253501-hkxlq3os	239	8	:	:	:
cord-253501-hkxlq3os	239	9	recognition	recognition	NN
cord-253501-hkxlq3os	239	10	and	and	CC
cord-253501-hkxlq3os	239	11	management	management	NN
cord-253501-hkxlq3os	239	12	Pegylated	Pegylated	NNP
cord-253501-hkxlq3os	239	13	interferon	interferon	NN
cord-253501-hkxlq3os	239	14	-	-	HYPH
cord-253501-hkxlq3os	239	15	alpha	alpha	NN
cord-253501-hkxlq3os	239	16	for	for	IN
cord-253501-hkxlq3os	239	17	treating	treat	VBG
cord-253501-hkxlq3os	239	18	chronic	chronic	JJ
cord-253501-hkxlq3os	239	19	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	239	20	E	e	NN
cord-253501-hkxlq3os	239	21	virus	virus	NN
cord-253501-hkxlq3os	239	22	infection	infection	NN
cord-253501-hkxlq3os	239	23	after	after	IN
cord-253501-hkxlq3os	239	24	liver	liver	NN
cord-253501-hkxlq3os	239	25	transplantation	transplantation	NN
cord-253501-hkxlq3os	240	1	Antiviral	antiviral	JJ
cord-253501-hkxlq3os	240	2	strategies	strategy	NNS
cord-253501-hkxlq3os	240	3	for	for	IN
cord-253501-hkxlq3os	240	4	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	5	E	e	NN
cord-253501-hkxlq3os	240	6	virus	virus	NN
cord-253501-hkxlq3os	240	7	Calcineurin	Calcineurin	NNP
cord-253501-hkxlq3os	240	8	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	240	9	stimulate	stimulate	VBP
cord-253501-hkxlq3os	240	10	and	and	CC
cord-253501-hkxlq3os	240	11	mycophenolic	mycophenolic	JJ
cord-253501-hkxlq3os	240	12	acid	acid	NN
cord-253501-hkxlq3os	240	13	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	240	14	replication	replication	NN
cord-253501-hkxlq3os	240	15	of	of	IN
cord-253501-hkxlq3os	240	16	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	17	E	E	NNP
cord-253501-hkxlq3os	240	18	virus	virus	NN
cord-253501-hkxlq3os	240	19	Cross	Cross	NNP
cord-253501-hkxlq3os	240	20	talk	talk	NN
cord-253501-hkxlq3os	240	21	between	between	IN
cord-253501-hkxlq3os	240	22	nucleotide	nucleotide	JJ
cord-253501-hkxlq3os	240	23	synthesis	synthesis	NN
cord-253501-hkxlq3os	240	24	pathways	pathway	NNS
cord-253501-hkxlq3os	240	25	with	with	IN
cord-253501-hkxlq3os	240	26	cellular	cellular	JJ
cord-253501-hkxlq3os	240	27	immunity	immunity	NN
cord-253501-hkxlq3os	240	28	in	in	IN
cord-253501-hkxlq3os	240	29	constraining	constrain	VBG
cord-253501-hkxlq3os	240	30	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	31	E	e	NN
cord-253501-hkxlq3os	240	32	virus	virus	NN
cord-253501-hkxlq3os	240	33	replication	replication	NN
cord-253501-hkxlq3os	240	34	Nucleoside	nucleoside	NN
cord-253501-hkxlq3os	240	35	analogue	analogue	JJ
cord-253501-hkxlq3os	240	36	2'-C	2'-c	CD
cord-253501-hkxlq3os	240	37	-	-	HYPH
cord-253501-hkxlq3os	240	38	methylcytidine	methylcytidine	NN
cord-253501-hkxlq3os	240	39	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	240	40	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	41	E	e	NN
cord-253501-hkxlq3os	240	42	virus	virus	NN
cord-253501-hkxlq3os	240	43	replication	replication	NN
cord-253501-hkxlq3os	240	44	but	but	CC
cord-253501-hkxlq3os	240	45	antagonizes	antagonize	VBZ
cord-253501-hkxlq3os	240	46	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	240	47	Sofosbuvir	Sofosbuvir	NNP
cord-253501-hkxlq3os	240	48	inhibits	inhibit	VBZ
cord-253501-hkxlq3os	240	49	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	50	E	e	NN
cord-253501-hkxlq3os	240	51	virus	virus	NN
cord-253501-hkxlq3os	240	52	replication	replication	NN
cord-253501-hkxlq3os	240	53	in	in	IN
cord-253501-hkxlq3os	240	54	vitro	vitro	FW
cord-253501-hkxlq3os	240	55	and	and	CC
cord-253501-hkxlq3os	240	56	results	result	NNS
cord-253501-hkxlq3os	240	57	in	in	IN
cord-253501-hkxlq3os	240	58	an	an	DT
cord-253501-hkxlq3os	240	59	additive	additive	NN
cord-253501-hkxlq3os	240	60	effect	effect	NN
cord-253501-hkxlq3os	240	61	when	when	WRB
cord-253501-hkxlq3os	240	62	combined	combine	VBN
cord-253501-hkxlq3os	240	63	with	with	IN
cord-253501-hkxlq3os	240	64	ribavirin	ribavirin	JJ
cord-253501-hkxlq3os	240	65	Distinct	distinct	JJ
cord-253501-hkxlq3os	240	66	antiviral	antiviral	JJ
cord-253501-hkxlq3os	240	67	potency	potency	NN
cord-253501-hkxlq3os	240	68	of	of	IN
cord-253501-hkxlq3os	240	69	sofosbuvir	sofosbuvir	NNP
cord-253501-hkxlq3os	240	70	against	against	IN
cord-253501-hkxlq3os	240	71	hepatitis	hepatitis	NNP
cord-253501-hkxlq3os	240	72	C	C	NNP
cord-253501-hkxlq3os	240	73	and	and	CC
cord-253501-hkxlq3os	240	74	E	e	NN
cord-253501-hkxlq3os	240	75	viruses	virus	NNS
cord-253501-hkxlq3os	240	76	Sofosbuvir	Sofosbuvir	NNP
cord-253501-hkxlq3os	240	77	and	and	CC
cord-253501-hkxlq3os	240	78	daclatasvir	daclatasvir	NNS
cord-253501-hkxlq3os	240	79	anti	anti	JJ
cord-253501-hkxlq3os	240	80	-	-	JJ
cord-253501-hkxlq3os	240	81	viral	viral	JJ
cord-253501-hkxlq3os	240	82	therapy	therapy	NN
cord-253501-hkxlq3os	240	83	fails	fail	VBZ
cord-253501-hkxlq3os	240	84	to	to	TO
cord-253501-hkxlq3os	240	85	clear	clear	VB
cord-253501-hkxlq3os	240	86	HEV	HEV	NNP
cord-253501-hkxlq3os	240	87	viremia	viremia	NN
cord-253501-hkxlq3os	240	88	and	and	CC
cord-253501-hkxlq3os	240	89	restore	restore	VB
cord-253501-hkxlq3os	240	90	reactive	reactive	JJ
cord-253501-hkxlq3os	240	91	t	t	NN
cord-253501-hkxlq3os	240	92	cells	cell	NNS
cord-253501-hkxlq3os	240	93	in	in	IN
cord-253501-hkxlq3os	240	94	a	a	DT
cord-253501-hkxlq3os	240	95	HEV	HEV	NNP
cord-253501-hkxlq3os	240	96	/	/	SYM
cord-253501-hkxlq3os	240	97	HCV	HCV	NNP
cord-253501-hkxlq3os	240	98	co	co	NN
cord-253501-hkxlq3os	240	99	-	-	JJ
cord-253501-hkxlq3os	240	100	infected	infected	JJ
cord-253501-hkxlq3os	240	101	liver	liver	NN
cord-253501-hkxlq3os	240	102	transplant	transplant	NN
cord-253501-hkxlq3os	240	103	recipient	recipient	NN
cord-253501-hkxlq3os	240	104	Inhibition	inhibition	NN
cord-253501-hkxlq3os	240	105	of	of	IN
cord-253501-hkxlq3os	240	106	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	240	107	E	e	NN
cord-253501-hkxlq3os	240	108	virus	virus	NN
cord-253501-hkxlq3os	240	109	replication	replication	NN
cord-253501-hkxlq3os	240	110	by	by	IN
cord-253501-hkxlq3os	240	111	peptide	peptide	NN
cord-253501-hkxlq3os	240	112	-	-	HYPH
cord-253501-hkxlq3os	240	113	conjugated	conjugate	VBN
cord-253501-hkxlq3os	240	114	morpholino	morpholino	NNP
cord-253501-hkxlq3os	240	115	oligomers	oligomer	NNS
cord-253501-hkxlq3os	241	1	A	a	DT
cord-253501-hkxlq3os	241	2	screen	screen	NN
cord-253501-hkxlq3os	241	3	for	for	IN
cord-253501-hkxlq3os	241	4	novel	novel	JJ
cord-253501-hkxlq3os	241	5	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	241	6	C	C	NNP
cord-253501-hkxlq3os	241	7	virus	virus	NN
cord-253501-hkxlq3os	241	8	RdRp	RdRp	NNP
cord-253501-hkxlq3os	241	9	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	241	10	identifies	identify	VBZ
cord-253501-hkxlq3os	241	11	a	a	DT
cord-253501-hkxlq3os	241	12	broad	broad	JJ
cord-253501-hkxlq3os	241	13	-	-	HYPH
cord-253501-hkxlq3os	241	14	spectrum	spectrum	NN
cord-253501-hkxlq3os	241	15	antiviral	antiviral	JJ
cord-253501-hkxlq3os	241	16	compound	compound	NN
cord-253501-hkxlq3os	241	17	Proteasome	Proteasome	NNP
cord-253501-hkxlq3os	241	18	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	241	19	:	:	:
cord-253501-hkxlq3os	241	20	an	an	DT
cord-253501-hkxlq3os	241	21	expanding	expand	VBG
cord-253501-hkxlq3os	241	22	army	army	NN
cord-253501-hkxlq3os	241	23	attacking	attack	VBG
cord-253501-hkxlq3os	241	24	a	a	DT
cord-253501-hkxlq3os	241	25	unique	unique	JJ
cord-253501-hkxlq3os	241	26	target	target	NN
cord-253501-hkxlq3os	241	27	Hepatitis	hepatitis	NN
cord-253501-hkxlq3os	241	28	E	e	NN
cord-253501-hkxlq3os	241	29	virus	virus	NN
cord-253501-hkxlq3os	241	30	replication	replication	NN
cord-253501-hkxlq3os	241	31	requires	require	VBZ
cord-253501-hkxlq3os	242	1	an	an	DT
cord-253501-hkxlq3os	242	2	active	active	JJ
cord-253501-hkxlq3os	242	3	ubiquitinproteasome	ubiquitinproteasome	NN
cord-253501-hkxlq3os	242	4	system	system	NN
cord-253501-hkxlq3os	242	5	Inhibition	inhibition	NN
cord-253501-hkxlq3os	242	6	of	of	IN
cord-253501-hkxlq3os	242	7	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	242	8	E	e	NN
cord-253501-hkxlq3os	242	9	virus	virus	NN
cord-253501-hkxlq3os	242	10	replication	replication	NN
cord-253501-hkxlq3os	242	11	by	by	IN
cord-253501-hkxlq3os	242	12	proteasome	proteasome	VBN
cord-253501-hkxlq3os	242	13	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	242	14	is	be	VBZ
cord-253501-hkxlq3os	242	15	nonspecific	nonspecific	JJ
cord-253501-hkxlq3os	242	16	Zinc	Zinc	NNP
cord-253501-hkxlq3os	242	17	salts	salt	NNS
cord-253501-hkxlq3os	242	18	block	block	NN
cord-253501-hkxlq3os	242	19	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	242	20	E	e	NN
cord-253501-hkxlq3os	242	21	virus	virus	NN
cord-253501-hkxlq3os	242	22	replication	replication	NN
cord-253501-hkxlq3os	242	23	by	by	IN
cord-253501-hkxlq3os	242	24	inhibiting	inhibit	VBG
cord-253501-hkxlq3os	242	25	the	the	DT
cord-253501-hkxlq3os	242	26	activity	activity	NN
cord-253501-hkxlq3os	242	27	of	of	IN
cord-253501-hkxlq3os	242	28	viral	viral	JJ
cord-253501-hkxlq3os	242	29	RNA	RNA	NNP
cord-253501-hkxlq3os	242	30	-	-	HYPH
cord-253501-hkxlq3os	242	31	dependent	dependent	JJ
cord-253501-hkxlq3os	242	32	RNA	RNA	NNP
cord-253501-hkxlq3os	242	33	polymerase	polymerase	NN
cord-253501-hkxlq3os	242	34	Zinc	zinc	NN
cord-253501-hkxlq3os	242	35	:	:	:
cord-253501-hkxlq3os	242	36	an	an	DT
cord-253501-hkxlq3os	242	37	overview	overview	NN
cord-253501-hkxlq3os	242	38	Zinc	zinc	NN
cord-253501-hkxlq3os	242	39	in	in	IN
cord-253501-hkxlq3os	242	40	innate	innate	JJ
cord-253501-hkxlq3os	242	41	and	and	CC
cord-253501-hkxlq3os	242	42	adaptive	adaptive	JJ
cord-253501-hkxlq3os	242	43	tumor	tumor	NN
cord-253501-hkxlq3os	242	44	immunity	immunity	NN
cord-253501-hkxlq3os	242	45	Zinc	zinc	NN
cord-253501-hkxlq3os	242	46	:	:	:
cord-253501-hkxlq3os	242	47	A	a	DT
cord-253501-hkxlq3os	242	48	complementary	complementary	JJ
cord-253501-hkxlq3os	242	49	factor	factor	NN
cord-253501-hkxlq3os	242	50	in	in	IN
cord-253501-hkxlq3os	242	51	the	the	DT
cord-253501-hkxlq3os	242	52	treatment	treatment	NN
cord-253501-hkxlq3os	242	53	of	of	IN
cord-253501-hkxlq3os	242	54	chronic	chronic	JJ
cord-253501-hkxlq3os	242	55	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	242	56	C	c	NN
cord-253501-hkxlq3os	242	57	?	?	.
cord-253501-hkxlq3os	243	1	(	(	-LRB-
cord-253501-hkxlq3os	243	2	Review	Review	NNP
cord-253501-hkxlq3os	243	3	)	)	-RRB-
cord-253501-hkxlq3os	243	4	Heparan	Heparan	NNP
cord-253501-hkxlq3os	243	5	sulfate	sulfate	NN
cord-253501-hkxlq3os	243	6	proteoglycans	proteoglycan	NNS
cord-253501-hkxlq3os	243	7	are	be	VBP
cord-253501-hkxlq3os	243	8	required	require	VBN
cord-253501-hkxlq3os	243	9	for	for	IN
cord-253501-hkxlq3os	243	10	cellular	cellular	JJ
cord-253501-hkxlq3os	243	11	binding	binding	NN
cord-253501-hkxlq3os	243	12	of	of	IN
cord-253501-hkxlq3os	243	13	the	the	DT
cord-253501-hkxlq3os	243	14	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	243	15	E	e	NN
cord-253501-hkxlq3os	243	16	virus	virus	NN
cord-253501-hkxlq3os	243	17	ORF2	ORF2	NNP
cord-253501-hkxlq3os	243	18	capsid	capsid	NN
cord-253501-hkxlq3os	243	19	protein	protein	NN
cord-253501-hkxlq3os	243	20	and	and	CC
cord-253501-hkxlq3os	243	21	for	for	IN
cord-253501-hkxlq3os	243	22	viral	viral	JJ
cord-253501-hkxlq3os	243	23	infection	infection	NN
cord-253501-hkxlq3os	243	24	Role	role	NN
cord-253501-hkxlq3os	243	25	of	of	IN
cord-253501-hkxlq3os	243	26	heat	heat	NN
cord-253501-hkxlq3os	243	27	-	-	HYPH
cord-253501-hkxlq3os	243	28	shock	shock	NN
cord-253501-hkxlq3os	243	29	protein	protein	NN
cord-253501-hkxlq3os	243	30	90	90	CD
cord-253501-hkxlq3os	243	31	in	in	IN
cord-253501-hkxlq3os	243	32	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	243	33	E	e	NN
cord-253501-hkxlq3os	243	34	virus	virus	NN
cord-253501-hkxlq3os	243	35	capsid	capsid	NN
cord-253501-hkxlq3os	243	36	trafficking	traffic	VBG
cord-253501-hkxlq3os	243	37	Homology	homology	NN
cord-253501-hkxlq3os	243	38	model	model	NN
cord-253501-hkxlq3os	243	39	and	and	CC
cord-253501-hkxlq3os	243	40	potential	potential	JJ
cord-253501-hkxlq3os	243	41	virus	virus	NN
cord-253501-hkxlq3os	243	42	-	-	HYPH
cord-253501-hkxlq3os	243	43	capsid	capsid	NN
cord-253501-hkxlq3os	243	44	binding	binding	NN
cord-253501-hkxlq3os	243	45	site	site	NN
cord-253501-hkxlq3os	243	46	of	of	IN
cord-253501-hkxlq3os	243	47	a	a	DT
cord-253501-hkxlq3os	243	48	putative	putative	JJ
cord-253501-hkxlq3os	243	49	HEV	hev	NN
cord-253501-hkxlq3os	243	50	receptor	receptor	NN
cord-253501-hkxlq3os	243	51	Grp78	Grp78	NNP
cord-253501-hkxlq3os	243	52	GRP78	GRP78	NNP
cord-253501-hkxlq3os	243	53	is	be	VBZ
cord-253501-hkxlq3os	243	54	an	an	DT
cord-253501-hkxlq3os	243	55	important	important	JJ
cord-253501-hkxlq3os	243	56	host	host	NN
cord-253501-hkxlq3os	243	57	factor	factor	NN
cord-253501-hkxlq3os	243	58	for	for	IN
cord-253501-hkxlq3os	243	59	japanese	japanese	JJ
cord-253501-hkxlq3os	243	60	encephalitis	encephalitis	NNP
cord-253501-hkxlq3os	243	61	virus	virus	NN
cord-253501-hkxlq3os	243	62	entry	entry	NN
cord-253501-hkxlq3os	243	63	and	and	CC
cord-253501-hkxlq3os	243	64	replication	replication	NN
cord-253501-hkxlq3os	243	65	in	in	IN
cord-253501-hkxlq3os	243	66	mammalian	mammalian	JJ
cord-253501-hkxlq3os	243	67	cells	cell	NNS
cord-253501-hkxlq3os	244	1	Virus	virus	NN
cord-253501-hkxlq3os	244	2	-	-	HYPH
cord-253501-hkxlq3os	244	3	specific	specific	JJ
cord-253501-hkxlq3os	244	4	mRNA	mrna	NN
cord-253501-hkxlq3os	244	5	capping	cap	VBG
cord-253501-hkxlq3os	244	6	enzyme	enzyme	NN
cord-253501-hkxlq3os	244	7	encoded	encode	VBN
cord-253501-hkxlq3os	244	8	by	by	IN
cord-253501-hkxlq3os	244	9	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	244	10	E	e	NN
cord-253501-hkxlq3os	244	11	virus	virus	NN
cord-253501-hkxlq3os	244	12	Conventional	conventional	JJ
cord-253501-hkxlq3os	244	13	and	and	CC
cord-253501-hkxlq3os	244	14	unconventional	unconventional	JJ
cord-253501-hkxlq3os	244	15	mechanisms	mechanism	NNS
cord-253501-hkxlq3os	244	16	for	for	IN
cord-253501-hkxlq3os	244	17	capping	cap	VBG
cord-253501-hkxlq3os	244	18	viral	viral	JJ
cord-253501-hkxlq3os	244	19	mRNA	mrna	NN
cord-253501-hkxlq3os	245	1	In	in	IN
cord-253501-hkxlq3os	245	2	vitro	vitro	FW
cord-253501-hkxlq3os	245	3	replication	replication	NN
cord-253501-hkxlq3os	245	4	of	of	IN
cord-253501-hkxlq3os	245	5	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	245	6	E	e	NN
cord-253501-hkxlq3os	245	7	virus	virus	NN
cord-253501-hkxlq3os	245	8	(	(	-LRB-
cord-253501-hkxlq3os	245	9	HEV	hev	NN
cord-253501-hkxlq3os	245	10	)	)	-RRB-
cord-253501-hkxlq3os	245	11	genomes	genome	NNS
cord-253501-hkxlq3os	245	12	and	and	CC
cord-253501-hkxlq3os	245	13	of	of	IN
cord-253501-hkxlq3os	245	14	an	an	DT
cord-253501-hkxlq3os	245	15	HEV	HEV	NNP
cord-253501-hkxlq3os	245	16	replicon	replicon	NN
cord-253501-hkxlq3os	245	17	expressing	express	VBG
cord-253501-hkxlq3os	245	18	green	green	JJ
cord-253501-hkxlq3os	245	19	fluorescent	fluorescent	NN
cord-253501-hkxlq3os	245	20	protein	protein	NN
cord-253501-hkxlq3os	246	1	The	the	DT
cord-253501-hkxlq3os	246	2	methyltransferase	methyltransferase	NN
cord-253501-hkxlq3os	246	3	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	246	4	Neplanocin	Neplanocin	NNP
cord-253501-hkxlq3os	246	5	A	A	NNP
cord-253501-hkxlq3os	246	6	interferes	interfere	VBZ
cord-253501-hkxlq3os	246	7	with	with	IN
cord-253501-hkxlq3os	246	8	influenza	influenza	NN
cord-253501-hkxlq3os	246	9	virus	virus	NN
cord-253501-hkxlq3os	246	10	replication	replication	NN
cord-253501-hkxlq3os	246	11	by	by	IN
cord-253501-hkxlq3os	246	12	a	a	DT
cord-253501-hkxlq3os	246	13	mechanism	mechanism	NN
cord-253501-hkxlq3os	246	14	different	different	JJ
cord-253501-hkxlq3os	246	15	from	from	IN
cord-253501-hkxlq3os	246	16	that	that	DT
cord-253501-hkxlq3os	246	17	of	of	IN
cord-253501-hkxlq3os	246	18	3-deazaadenosine	3-deazaadenosine	CD
cord-253501-hkxlq3os	246	19	A	a	DT
cord-253501-hkxlq3os	246	20	potent	potent	JJ
cord-253501-hkxlq3os	246	21	inhibitor	inhibitor	NN
cord-253501-hkxlq3os	246	22	of	of	IN
cord-253501-hkxlq3os	246	23	S	S	NNP
cord-253501-hkxlq3os	246	24	-	-	HYPH
cord-253501-hkxlq3os	246	25	adenosylhomocysteine	adenosylhomocysteine	NNP
cord-253501-hkxlq3os	246	26	hydrolase	hydrolase	NN
cord-253501-hkxlq3os	246	27	and	and	CC
cord-253501-hkxlq3os	246	28	of	of	IN
cord-253501-hkxlq3os	246	29	vaccinia	vaccinia	NN
cord-253501-hkxlq3os	246	30	virus	virus	NN
cord-253501-hkxlq3os	246	31	multiplication	multiplication	NN
cord-253501-hkxlq3os	246	32	in	in	IN
cord-253501-hkxlq3os	246	33	mouse	mouse	NN
cord-253501-hkxlq3os	246	34	L929	l929	CD
cord-253501-hkxlq3os	246	35	cells	cell	NNS
cord-253501-hkxlq3os	246	36	Development	Development	NNP
cord-253501-hkxlq3os	246	37	of	of	IN
cord-253501-hkxlq3os	246	38	specific	specific	JJ
cord-253501-hkxlq3os	246	39	dengue	dengue	NN
cord-253501-hkxlq3os	246	40	virus	virus	NN
cord-253501-hkxlq3os	246	41	2'-O	2'-o	CD
cord-253501-hkxlq3os	246	42	-	-	:
cord-253501-hkxlq3os	246	43	and	and	CC
cord-253501-hkxlq3os	246	44	N7-methyltransferase	N7-methyltransferase	NNP
cord-253501-hkxlq3os	246	45	assays	assay	NNS
cord-253501-hkxlq3os	246	46	for	for	IN
cord-253501-hkxlq3os	246	47	antiviral	antiviral	JJ
cord-253501-hkxlq3os	246	48	drug	drug	NN
cord-253501-hkxlq3os	246	49	screening	screening	NN
cord-253501-hkxlq3os	247	1	NS5A	NS5A	NNP
cord-253501-hkxlq3os	248	1	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	248	2	in	in	IN
cord-253501-hkxlq3os	248	3	the	the	DT
cord-253501-hkxlq3os	248	4	treatment	treatment	NN
cord-253501-hkxlq3os	248	5	of	of	IN
cord-253501-hkxlq3os	248	6	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	248	7	C	C	NNP
cord-253501-hkxlq3os	248	8	Endoplasmic	Endoplasmic	NNP
cord-253501-hkxlq3os	248	9	reticulum	reticulum	NN
cord-253501-hkxlq3os	248	10	stress	stress	NN
cord-253501-hkxlq3os	248	11	induced	induce	VBD
cord-253501-hkxlq3os	248	12	synthesis	synthesis	NN
cord-253501-hkxlq3os	248	13	of	of	IN
cord-253501-hkxlq3os	248	14	a	a	DT
cord-253501-hkxlq3os	248	15	novel	novel	JJ
cord-253501-hkxlq3os	248	16	viral	viral	JJ
cord-253501-hkxlq3os	248	17	factor	factor	NN
cord-253501-hkxlq3os	248	18	mediates	mediate	VBZ
cord-253501-hkxlq3os	248	19	efficient	efficient	JJ
cord-253501-hkxlq3os	248	20	replication	replication	NN
cord-253501-hkxlq3os	248	21	of	of	IN
cord-253501-hkxlq3os	248	22	genotype-1	genotype-1	NNP
cord-253501-hkxlq3os	248	23	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	248	24	E	e	NN
cord-253501-hkxlq3os	248	25	virus	virus	NN
cord-253501-hkxlq3os	248	26	Hostvirus	Hostvirus	NNP
cord-253501-hkxlq3os	248	27	protein	protein	NN
cord-253501-hkxlq3os	248	28	interaction	interaction	NN
cord-253501-hkxlq3os	248	29	network	network	NN
cord-253501-hkxlq3os	248	30	reveals	reveal	VBZ
cord-253501-hkxlq3os	248	31	the	the	DT
cord-253501-hkxlq3os	248	32	involvement	involvement	NN
cord-253501-hkxlq3os	248	33	of	of	IN
cord-253501-hkxlq3os	248	34	multiple	multiple	JJ
cord-253501-hkxlq3os	248	35	host	host	NN
cord-253501-hkxlq3os	248	36	processes	process	NNS
cord-253501-hkxlq3os	248	37	in	in	IN
cord-253501-hkxlq3os	248	38	the	the	DT
cord-253501-hkxlq3os	248	39	life	life	NN
cord-253501-hkxlq3os	248	40	cycle	cycle	NN
cord-253501-hkxlq3os	248	41	of	of	IN
cord-253501-hkxlq3os	248	42	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	248	43	E	E	NNP
cord-253501-hkxlq3os	248	44	virus	virus	NN
cord-253501-hkxlq3os	248	45	RNA	rna	NN
cord-253501-hkxlq3os	248	46	5'-triphosphatase	5'-triphosphatase	CD
cord-253501-hkxlq3os	248	47	activity	activity	NN
cord-253501-hkxlq3os	248	48	of	of	IN
cord-253501-hkxlq3os	248	49	the	the	DT
cord-253501-hkxlq3os	248	50	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	248	51	E	e	NN
cord-253501-hkxlq3os	248	52	virus	virus	NN
cord-253501-hkxlq3os	248	53	helicase	helicase	NN
cord-253501-hkxlq3os	248	54	domain	domain	NN
cord-253501-hkxlq3os	248	55	Understanding	understanding	NN
cord-253501-hkxlq3os	248	56	helicases	helicase	NNS
cord-253501-hkxlq3os	248	57	as	as	IN
cord-253501-hkxlq3os	248	58	a	a	DT
cord-253501-hkxlq3os	248	59	means	means	NN
cord-253501-hkxlq3os	248	60	of	of	IN
cord-253501-hkxlq3os	248	61	virus	virus	NN
cord-253501-hkxlq3os	248	62	control	control	NN
cord-253501-hkxlq3os	248	63	Herpes	Herpes	NNP
cord-253501-hkxlq3os	248	64	simplex	simplex	NN
cord-253501-hkxlq3os	248	65	virus	virus	NN
cord-253501-hkxlq3os	248	66	helicase	helicase	NN
cord-253501-hkxlq3os	248	67	-	-	HYPH
cord-253501-hkxlq3os	248	68	primase	primase	NN
cord-253501-hkxlq3os	248	69	inhibitors	inhibitor	NNS
cord-253501-hkxlq3os	248	70	are	be	VBP
cord-253501-hkxlq3os	248	71	active	active	JJ
cord-253501-hkxlq3os	248	72	in	in	IN
cord-253501-hkxlq3os	248	73	animal	animal	NN
cord-253501-hkxlq3os	248	74	models	model	NNS
cord-253501-hkxlq3os	248	75	of	of	IN
cord-253501-hkxlq3os	248	76	human	human	JJ
cord-253501-hkxlq3os	248	77	disease	disease	NN
cord-253501-hkxlq3os	249	1	Opportunistic	opportunistic	JJ
cord-253501-hkxlq3os	249	2	intruders	intruder	NNS
cord-253501-hkxlq3os	250	1	:	:	:
cord-253501-hkxlq3os	250	2	how	how	WRB
cord-253501-hkxlq3os	250	3	viruses	virus	NNS
cord-253501-hkxlq3os	250	4	orchestrate	orchestrate	VBP
cord-253501-hkxlq3os	250	5	ER	er	NN
cord-253501-hkxlq3os	250	6	functions	function	NNS
cord-253501-hkxlq3os	250	7	to	to	TO
cord-253501-hkxlq3os	250	8	infect	infect	VB
cord-253501-hkxlq3os	250	9	cells	cell	NNS
cord-253501-hkxlq3os	250	10	Inhibition	inhibition	NN
cord-253501-hkxlq3os	250	11	of	of	IN
cord-253501-hkxlq3os	250	12	HIV	HIV	NNP
cord-253501-hkxlq3os	250	13	budding	bud	VBG
cord-253501-hkxlq3os	250	14	by	by	IN
cord-253501-hkxlq3os	250	15	a	a	DT
cord-253501-hkxlq3os	250	16	genetically	genetically	RB
cord-253501-hkxlq3os	250	17	selected	select	VBN
cord-253501-hkxlq3os	250	18	cyclic	cyclic	JJ
cord-253501-hkxlq3os	250	19	peptide	peptide	NN
cord-253501-hkxlq3os	250	20	targeting	target	VBG
cord-253501-hkxlq3os	250	21	the	the	DT
cord-253501-hkxlq3os	250	22	Gag	Gag	NNP
cord-253501-hkxlq3os	250	23	-	-	HYPH
cord-253501-hkxlq3os	250	24	TSG101	TSG101	NNP
cord-253501-hkxlq3os	250	25	interaction	interaction	NN
cord-253501-hkxlq3os	250	26	Enhanced	enhance	VBN
cord-253501-hkxlq3os	250	27	alpha1	alpha1	NN
cord-253501-hkxlq3os	250	28	microglobulin	microglobulin	NN
cord-253501-hkxlq3os	250	29	secretion	secretion	NN
cord-253501-hkxlq3os	250	30	from	from	IN
cord-253501-hkxlq3os	250	31	Hepatitis	Hepatitis	NNP
cord-253501-hkxlq3os	250	32	E	E	NNP
cord-253501-hkxlq3os	250	33	virus	virus	NN
cord-253501-hkxlq3os	250	34	ORF3-expressing	orf3-expresse	VBG
cord-253501-hkxlq3os	250	35	human	human	JJ
cord-253501-hkxlq3os	250	36	hepatoma	hepatoma	NNP
cord-253501-hkxlq3os	250	37	cells	cell	NNS
cord-253501-hkxlq3os	250	38	is	be	VBZ
cord-253501-hkxlq3os	250	39	mediated	mediate	VBN
cord-253501-hkxlq3os	250	40	by	by	IN
cord-253501-hkxlq3os	250	41	the	the	DT
cord-253501-hkxlq3os	250	42	tumor	tumor	NN
cord-253501-hkxlq3os	250	43	susceptibility	susceptibility	NN
cord-253501-hkxlq3os	250	44	gene	gene	NN
cord-253501-hkxlq3os	250	45	101	101	CD
cord-253501-hkxlq3os	251	1	A	a	DT
cord-253501-hkxlq3os	251	2	PSAP	psap	JJ
cord-253501-hkxlq3os	251	3	motif	motif	NN
cord-253501-hkxlq3os	251	4	in	in	IN
cord-253501-hkxlq3os	251	5	the	the	DT
cord-253501-hkxlq3os	251	6	ORF3	ORF3	NNP
cord-253501-hkxlq3os	251	7	protein	protein	NN
cord-253501-hkxlq3os	251	8	of	of	IN
cord-253501-hkxlq3os	251	9	hepatitis	hepatitis	NN
cord-253501-hkxlq3os	251	10	E	e	NN
cord-253501-hkxlq3os	251	11	virus	virus	NN
cord-253501-hkxlq3os	251	12	is	be	VBZ
cord-253501-hkxlq3os	251	13	necessary	necessary	JJ
cord-253501-hkxlq3os	251	14	for	for	IN
cord-253501-hkxlq3os	251	15	virion	virion	NN
cord-253501-hkxlq3os	251	16	release	release	NN
cord-253501-hkxlq3os	251	17	from	from	IN
cord-253501-hkxlq3os	251	18	infected	infected	JJ
cord-253501-hkxlq3os	251	19	cells	cell	NNS