id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-002686-zzongyfa	Oany, Arafat Rahman	Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA	2017-09-07		.txt	text/plain	4966	265	47	In the present study, we have tried to impose the vaccinomics approach for designing a common peptide vaccine candidate against the immunogenic SigA of Shigella spp. Initially, these peptides were assessed for the affinity with MHC class I and class II alleles, and four potential core epitopes VTARAGLGY, FHTVTVNTL, HTTWTLTGY, and IELAGTLTL were selected. The generalized modules of membrane antigen-(GMMA-) based outer membrane proteins including SigA were also shown to be highly immunogenic [12] , which prompted us to target SigA as one of the best vaccine candidates and to design potential peptide vaccine covering all the Shigella spp. The SigA protein sequences of different strains of Shigella species were retrieved from the NCBI GenBank [22] database and analysed in the VaxiJen v2.0 [23] server for the determination of the most potent antigenic protein. IEDB analysis resource predicted both MHC class I-and MHC class II-based coverage of the selected epitopes for the world population to assess the feasibility of being a potential vaccine candidate.	./cache/cord-002686-zzongyfa.txt	./txt/cord-002686-zzongyfa.txt