id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-275677-hbv49e01	Ramana, Lakshmi Narashimhan	Targeting strategies for delivery of anti-HIV drugs	2014-10-28		.txt	text/plain	12944	571	42	Immunoliposomes loaded with the protease inhibitor indinavir and surface modified with anti-HLA-DR were found to effectively bind to HIV infected cells and deliver the antiretroviral drug leading to a significant reduction in the viral load [44] . In a recent work, lipid nanoparticles conjugated with two peptide sequences that were derived from the binding domains of CD4 designated as CD4-BP2 and CD4-BP4 were used for targeted delivery of the protease inhibitor indinavir to HIV infected CD4 + cells with high specificity [54] . The lectin actinohivin isolated from the actinomycete Longisporum albida has also been identified as an important targeting moiety that binds to the mannose residues present in the gp120 at lower concentrations with an affinity greater than anti-gp120 antibodies thereby preventing the interaction of the viral glycoprotein with CXCR4 and CCR5 chemokine receptors [13] .	./cache/cord-275677-hbv49e01.txt	./txt/cord-275677-hbv49e01.txt