id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329669-z3t7plvh	Poulton, Kay	A role for human leucocyte antigens in the susceptibility to SARS‐Cov‐2 infection observed in transplant patients	2020-07-05		.txt	text/plain	2270	124	50	HLA frequencies observed were compared against two control populations: first, against published frequencies in a UK deceased donor population (n = 10,000) representing the target population of the virus, and second, using a cohort of individuals from the combined transplant waiting lists of both centres (n = 308), representing a comparator group of unaffected individuals of the same demographic. This study investigated HLA profiles of patients admitted with PCR-confirmed SARS-CoV-2 infection to identify any potential HLA bias which might indicate an impaired capacity to mount an effective immune response to the infection. All patients included in the study had previously been HLA typed to support transplantation and required hospital treatment for COVID-19 disease, indicating that their symptoms were severe, requiring clinical support or intervention. Statistical analysis was performed using MedCalc v19.3 (MedCalc Software) to compare frequencies of allele group carriage between the patient and control populations using Fisher's exact test.	./cache/cord-329669-z3t7plvh.txt	./txt/cord-329669-z3t7plvh.txt