id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352150-ey9kc7zj	Degauque, Nicolas	Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation	2016-03-24		.txt	text/plain	7844	367	46	Keywords: TCR repertoire, transplantation, cross-reactivity, alloreactivity, TCR, MHC, T cell UNDeRSTANDiNG THe CROSS-ReACTiviTY Shaping the T Lymphocyte Receptor Repertoire Through evolution, numerous processes have been selected to generate a diverse repertoire of TCRαβ able to protect mammalian from pathogenic insults (Figure 1) . Despite the high diversity of the TCR repertoire, a high degree of cross-reactivity has been reported that could be explained by the "natural" ability of TCR to interact with MHC molecules (MHC focus model) as well as the interaction of TCR to a limited number of amino acids of the peptide bound to the MHC peptide groove. Cross-reactivity can be defined by the ability of a given TCR to interact with more than one pMHC complex with different presented peptides or MHC molecules. Before presenting the experimental approach aiming to quantify the number of peptides recognized by a single TCR, we would like to present clear evidences of the cross-reactivity involving memory T cells without previous antigen encounter.	./cache/cord-352150-ey9kc7zj.txt	./txt/cord-352150-ey9kc7zj.txt