id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-331244-zaguyxm5	Stephenson, Iain	Confronting the avian influenza threat: vaccine development for a potential pandemic	2004-07-30		.txt	text/plain	8192	452	38	In clinical trials, conventional surfaceantigen influenza virus vaccines produced from avian viruses have proved poorly immunogenic in immunologically naive populations. In clinical trials, conventional surfaceantigen influenza virus vaccines produced from avian viruses have proved poorly immunogenic in immunologically naive populations. The main antigenic determinants of influenza A and B viruses are two surface glycoproteins: the neuraminidase and the haemagglutinin, both capable of eliciting immune responses in human beings. Pandemic influenza viruses arise by this process of "antigenic shift", when a virus with a new haemagglutinin subtype emerges and spreads efficiently in a naive human population. 14 These reassortant viruses have haemagglutinin receptor-binding sequences potentially capable of human infection, suggesting that new viruses may emerge directly from the avian pool. Improved understanding of the antigenic and molecular associations between potential pandemic strains of same subtype Improved understanding of immunogenicity against drifted avian influenza strains is required as the ability to generate broad crossprotective immunity is desirable in vaccine candidate.	./cache/cord-331244-zaguyxm5.txt	./txt/cord-331244-zaguyxm5.txt