id	sid	tid	token	lemma	pos
cord-006702-ekf6mja9	1	1	key	key	JJ
cord-006702-ekf6mja9	2	1	:	:	:
cord-006702-ekf6mja9	2	2	cord-006702-ekf6mja9	cord-006702-ekf6mja9	JJ
cord-006702-ekf6mja9	2	3	authors	author	NNS
cord-006702-ekf6mja9	2	4	:	:	:
cord-006702-ekf6mja9	3	1	nan	nan	NNP
cord-006702-ekf6mja9	3	2	title	title	NN
cord-006702-ekf6mja9	3	3	:	:	:
cord-006702-ekf6mja9	3	4	Abstracts	abstract	NNS
cord-006702-ekf6mja9	3	5	for	for	IN
cord-006702-ekf6mja9	3	6	the	the	DT
cord-006702-ekf6mja9	3	7	17th	17th	JJ
cord-006702-ekf6mja9	3	8	IPNA	IPNA	NNP
cord-006702-ekf6mja9	3	9	Congress	Congress	NNP
cord-006702-ekf6mja9	3	10	,	,	,
cord-006702-ekf6mja9	3	11	Iguaçu	Iguaçu	NNP
cord-006702-ekf6mja9	3	12	,	,	,
cord-006702-ekf6mja9	3	13	Brazil	Brazil	NNP
cord-006702-ekf6mja9	3	14	,	,	,
cord-006702-ekf6mja9	3	15	September	September	NNP
cord-006702-ekf6mja9	3	16	2016	2016	CD
cord-006702-ekf6mja9	3	17	:	:	:
cord-006702-ekf6mja9	3	18	Oral	oral	JJ
cord-006702-ekf6mja9	3	19	Presentations	presentation	NNS
cord-006702-ekf6mja9	3	20	date	date	NN
cord-006702-ekf6mja9	3	21	:	:	:
cord-006702-ekf6mja9	3	22	2016	2016	CD
cord-006702-ekf6mja9	3	23	-	-	HYPH
cord-006702-ekf6mja9	3	24	08	08	CD
cord-006702-ekf6mja9	3	25	-	-	SYM
cord-006702-ekf6mja9	3	26	17	17	CD
cord-006702-ekf6mja9	3	27	journal	journal	NN
cord-006702-ekf6mja9	3	28	:	:	:
cord-006702-ekf6mja9	3	29	Pediatr	Pediatr	NNP
cord-006702-ekf6mja9	3	30	Nephrol	Nephrol	NNP
cord-006702-ekf6mja9	3	31	DOI	DOI	NNP
cord-006702-ekf6mja9	3	32	:	:	:
cord-006702-ekf6mja9	4	1	10.1007	10.1007	CD
cord-006702-ekf6mja9	4	2	/	/	SYM
cord-006702-ekf6mja9	4	3	s00467	s00467	NNP
cord-006702-ekf6mja9	4	4	-	-	HYPH
cord-006702-ekf6mja9	4	5	016	016	CD
cord-006702-ekf6mja9	4	6	-	-	HYPH
cord-006702-ekf6mja9	4	7	3466	3466	CD
cord-006702-ekf6mja9	4	8	-	-	SYM
cord-006702-ekf6mja9	4	9	6	6	CD
cord-006702-ekf6mja9	4	10	sha	sha	NN
cord-006702-ekf6mja9	4	11	:	:	:
cord-006702-ekf6mja9	4	12	95945b7789ceabe38b5c41d83756ad10300c8add	95945b7789ceabe38b5c41d83756ad10300c8add	CD
cord-006702-ekf6mja9	4	13	doc_id	doc_id	CD
cord-006702-ekf6mja9	4	14	:	:	:
cord-006702-ekf6mja9	4	15	6702	6702	CD
cord-006702-ekf6mja9	4	16	cord_uid	cord_uid	NNS
cord-006702-ekf6mja9	4	17	:	:	:
cord-006702-ekf6mja9	4	18	ekf6mja9	ekf6mja9	NNS
cord-006702-ekf6mja9	5	1	nan	nan	NNP
cord-006702-ekf6mja9	5	2	2	2	CD
cord-006702-ekf6mja9	5	3	years	year	NNS
cord-006702-ekf6mja9	5	4	was	be	VBD
cord-006702-ekf6mja9	5	5	67	67	CD
cord-006702-ekf6mja9	5	6	%	%	NN
cord-006702-ekf6mja9	5	7	for	for	IN
cord-006702-ekf6mja9	5	8	PBS	PBS	NNP
cord-006702-ekf6mja9	5	9	and	and	CC
cord-006702-ekf6mja9	5	10	similar	similar	JJ
cord-006702-ekf6mja9	5	11	to	to	IN
cord-006702-ekf6mja9	5	12	COU	COU	NNP
cord-006702-ekf6mja9	5	13	(	(	-LRB-
cord-006702-ekf6mja9	5	14	71	71	CD
cord-006702-ekf6mja9	5	15	%	%	NN
cord-006702-ekf6mja9	5	16	)	)	-RRB-
cord-006702-ekf6mja9	5	17	and	and	CC
cord-006702-ekf6mja9	5	18	RHD	RHD	NNP
cord-006702-ekf6mja9	5	19	(	(	-LRB-
cord-006702-ekf6mja9	5	20	68	68	CD
cord-006702-ekf6mja9	5	21	%	%	NN
cord-006702-ekf6mja9	5	22	)	)	-RRB-
cord-006702-ekf6mja9	5	23	.	.	.
cord-006702-ekf6mja9	6	1	Age	age	NN
cord-006702-ekf6mja9	6	2	-	-	HYPH
cord-006702-ekf6mja9	6	3	adjusted	adjust	VBN
cord-006702-ekf6mja9	6	4	death	death	NN
cord-006702-ekf6mja9	6	5	-	-	HYPH
cord-006702-ekf6mja9	6	6	censored	censor	VBN
cord-006702-ekf6mja9	6	7	risk	risk	NN
cord-006702-ekf6mja9	6	8	of	of	IN
cord-006702-ekf6mja9	6	9	graft	graft	NN
cord-006702-ekf6mja9	6	10	loss	loss	NN
cord-006702-ekf6mja9	6	11	was	be	VBD
cord-006702-ekf6mja9	6	12	not	not	RB
cord-006702-ekf6mja9	6	13	significantly	significantly	RB
cord-006702-ekf6mja9	6	14	different	different	JJ
cord-006702-ekf6mja9	6	15	for	for	IN
cord-006702-ekf6mja9	6	16	PBS	PBS	NNP
cord-006702-ekf6mja9	6	17	as	as	IN
cord-006702-ekf6mja9	6	18	compared	compare	VBN
cord-006702-ekf6mja9	6	19	to	to	IN
cord-006702-ekf6mja9	6	20	COU	COU	NNP
cord-006702-ekf6mja9	6	21	(	(	-LRB-
cord-006702-ekf6mja9	6	22	HR	HR	NNP
cord-006702-ekf6mja9	6	23	0.94	0.94	CD
cord-006702-ekf6mja9	6	24	;	;	:
cord-006702-ekf6mja9	6	25	95	95	CD
cord-006702-ekf6mja9	6	26	%	%	NN
cord-006702-ekf6mja9	6	27	CI	CI	NNP
cord-006702-ekf6mja9	6	28	0.65	0.65	CD
cord-006702-ekf6mja9	6	29	-	-	HYPH
cord-006702-ekf6mja9	6	30	1.38	1.38	CD
cord-006702-ekf6mja9	6	31	)	)	-RRB-
cord-006702-ekf6mja9	6	32	or	or	CC
cord-006702-ekf6mja9	6	33	compared	compare	VBN
cord-006702-ekf6mja9	6	34	to	to	IN
cord-006702-ekf6mja9	6	35	RHD	RHD	NNP
cord-006702-ekf6mja9	6	36	(	(	-LRB-
cord-006702-ekf6mja9	6	37	HR	hr	NN
cord-006702-ekf6mja9	6	38	:	:	:
cord-006702-ekf6mja9	6	39	0.98	0.98	CD
cord-006702-ekf6mja9	6	40	;	;	:
cord-006702-ekf6mja9	6	41	95	95	CD
cord-006702-ekf6mja9	6	42	%	%	NN
cord-006702-ekf6mja9	6	43	CI	CI	NNP
cord-006702-ekf6mja9	6	44	0.67	0.67	CD
cord-006702-ekf6mja9	6	45	-	-	SYM
cord-006702-ekf6mja9	6	46	1.42	1.42	CD
cord-006702-ekf6mja9	6	47	)	)	-RRB-
cord-006702-ekf6mja9	6	48	.	.	.
cord-006702-ekf6mja9	7	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	7	2	:	:	:
cord-006702-ekf6mja9	8	1	In	in	IN
cord-006702-ekf6mja9	8	2	contrast	contrast	NN
cord-006702-ekf6mja9	8	3	to	to	IN
cord-006702-ekf6mja9	8	4	previous	previous	JJ
cord-006702-ekf6mja9	8	5	reports	report	NNS
cord-006702-ekf6mja9	8	6	,	,	,
cord-006702-ekf6mja9	8	7	we	-PRON-	PRP
cord-006702-ekf6mja9	8	8	found	find	VBD
cord-006702-ekf6mja9	8	9	encouraging	encouraging	JJ
cord-006702-ekf6mja9	8	10	outcomes	outcome	NNS
cord-006702-ekf6mja9	8	11	in	in	IN
cord-006702-ekf6mja9	8	12	the	the	DT
cord-006702-ekf6mja9	8	13	largest	large	JJS
cord-006702-ekf6mja9	8	14	cohort	cohort	NN
cord-006702-ekf6mja9	8	15	of	of	IN
cord-006702-ekf6mja9	8	16	PBS	PBS	NNP
cord-006702-ekf6mja9	8	17	children	child	NNS
cord-006702-ekf6mja9	8	18	on	on	IN
cord-006702-ekf6mja9	8	19	RRT	RRT	NNP
cord-006702-ekf6mja9	8	20	reported	report	VBD
cord-006702-ekf6mja9	8	21	so	so	RB
cord-006702-ekf6mja9	8	22	far	far	RB
cord-006702-ekf6mja9	8	23	,	,	,
cord-006702-ekf6mja9	8	24	which	which	WDT
cord-006702-ekf6mja9	8	25	were	be	VBD
cord-006702-ekf6mja9	8	26	similar	similar	JJ
cord-006702-ekf6mja9	8	27	to	to	IN
cord-006702-ekf6mja9	8	28	those	those	DT
cord-006702-ekf6mja9	8	29	with	with	IN
cord-006702-ekf6mja9	8	30	renal	renal	JJ
cord-006702-ekf6mja9	8	31	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	8	32	.	.	.
cord-006702-ekf6mja9	9	1	The	the	DT
cord-006702-ekf6mja9	9	2	protective	protective	JJ
cord-006702-ekf6mja9	9	3	arm	arm	NN
cord-006702-ekf6mja9	9	4	of	of	IN
cord-006702-ekf6mja9	9	5	the	the	DT
cord-006702-ekf6mja9	9	6	Renin	Renin	NNP
cord-006702-ekf6mja9	9	7	Angiotensin	Angiotensin	NNP
cord-006702-ekf6mja9	9	8	System	System	NNP
cord-006702-ekf6mja9	9	9	may	may	MD
cord-006702-ekf6mja9	9	10	counteract	counteract	VB
cord-006702-ekf6mja9	9	11	the	the	DT
cord-006702-ekf6mja9	9	12	intense	intense	JJ
cord-006702-ekf6mja9	9	13	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	9	14	process	process	NN
cord-006702-ekf6mja9	9	15	in	in	IN
cord-006702-ekf6mja9	9	16	fetuses	fetus	NNS
cord-006702-ekf6mja9	9	17	with	with	IN
cord-006702-ekf6mja9	9	18	posterior	posterior	JJ
cord-006702-ekf6mja9	9	19	urethral	urethral	JJ
cord-006702-ekf6mja9	9	20	valves	valve	NNS
cord-006702-ekf6mja9	9	21	T.R.R.	T.R.R.	NNP
cord-006702-ekf6mja9	9	22	Prestes	Prestes	NNP
cord-006702-ekf6mja9	9	23	(	(	-LRB-
cord-006702-ekf6mja9	9	24	1	1	CD
cord-006702-ekf6mja9	9	25	)	)	-RRB-
cord-006702-ekf6mja9	9	26	,	,	,
cord-006702-ekf6mja9	9	27	É.L.M.	É.L.M.	NNP
cord-006702-ekf6mja9	9	28	Vieira	Vieira	NNP
cord-006702-ekf6mja9	9	29	(	(	-LRB-
cord-006702-ekf6mja9	9	30	1	1	CD
cord-006702-ekf6mja9	9	31	)	)	-RRB-
cord-006702-ekf6mja9	9	32	,	,	,
cord-006702-ekf6mja9	9	33	F.M.	F.M.	NNP
cord-006702-ekf6mja9	9	34	Bastos	Bastos	NNP
cord-006702-ekf6mja9	9	35	(	(	-LRB-
cord-006702-ekf6mja9	9	36	1	1	CD
cord-006702-ekf6mja9	9	37	)	)	-RRB-
cord-006702-ekf6mja9	9	38	,	,	,
cord-006702-ekf6mja9	9	39	L.M.	L.M.	NNP
cord-006702-ekf6mja9	9	40	Kangussu	Kangussu	NNP
cord-006702-ekf6mja9	9	41	(	(	-LRB-
cord-006702-ekf6mja9	9	42	1	1	CD
cord-006702-ekf6mja9	9	43	)	)	-RRB-
cord-006702-ekf6mja9	9	44	,	,	,
cord-006702-ekf6mja9	9	45	N.P.	N.P.	NNP
cord-006702-ekf6mja9	9	46	Rocha	Rocha	NNP
cord-006702-ekf6mja9	9	47	(	(	-LRB-
cord-006702-ekf6mja9	9	48	2	2	CD
cord-006702-ekf6mja9	9	49	)	)	-RRB-
cord-006702-ekf6mja9	9	50	,	,	,
cord-006702-ekf6mja9	9	51	A.C.	A.C.	NNP
cord-006702-ekf6mja9	9	52	Simoes	Simoes	NNP
cord-006702-ekf6mja9	9	53	E	E	NNP
cord-006702-ekf6mja9	9	54	Silva	Silva	NNP
cord-006702-ekf6mja9	9	55	(	(	-LRB-
cord-006702-ekf6mja9	9	56	1	1	CD
cord-006702-ekf6mja9	9	57	)	)	-RRB-
cord-006702-ekf6mja9	9	58	(	(	-LRB-
cord-006702-ekf6mja9	9	59	1	1	CD
cord-006702-ekf6mja9	9	60	)	)	-RRB-
cord-006702-ekf6mja9	9	61	UFMG	UFMG	NNP
cord-006702-ekf6mja9	9	62	,	,	,
cord-006702-ekf6mja9	9	63	Brazil	Brazil	NNP
cord-006702-ekf6mja9	9	64	,	,	,
cord-006702-ekf6mja9	9	65	Belo	Belo	NNP
cord-006702-ekf6mja9	9	66	Horizonte	Horizonte	NNP
cord-006702-ekf6mja9	9	67	,	,	,
cord-006702-ekf6mja9	9	68	Brazil	Brazil	NNP
cord-006702-ekf6mja9	9	69	;	;	:
cord-006702-ekf6mja9	9	70	(	(	-LRB-
cord-006702-ekf6mja9	9	71	2	2	LS
cord-006702-ekf6mja9	9	72	)	)	-RRB-
cord-006702-ekf6mja9	9	73	Universiy	Universiy	NNP
cord-006702-ekf6mja9	9	74	of	of	IN
cord-006702-ekf6mja9	9	75	Texas	Texas	NNP
cord-006702-ekf6mja9	9	76	,	,	,
cord-006702-ekf6mja9	9	77	Houston	Houston	NNP
cord-006702-ekf6mja9	9	78	,	,	,
cord-006702-ekf6mja9	9	79	United	United	NNP
cord-006702-ekf6mja9	9	80	States	States	NNP
cord-006702-ekf6mja9	9	81	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	9	82	:	:	:
cord-006702-ekf6mja9	10	1	Previous	previous	JJ
cord-006702-ekf6mja9	10	2	studies	study	NNS
cord-006702-ekf6mja9	10	3	showed	show	VBD
cord-006702-ekf6mja9	10	4	that	that	IN
cord-006702-ekf6mja9	10	5	cytokines	cytokine	NNS
cord-006702-ekf6mja9	10	6	,	,	,
cord-006702-ekf6mja9	10	7	chemokines	chemokine	NNS
cord-006702-ekf6mja9	10	8	and	and	CC
cord-006702-ekf6mja9	10	9	components	component	NNS
cord-006702-ekf6mja9	10	10	of	of	IN
cord-006702-ekf6mja9	10	11	the	the	DT
cord-006702-ekf6mja9	10	12	Renin	Renin	NNP
cord-006702-ekf6mja9	10	13	Angiotensin	Angiotensin	NNP
cord-006702-ekf6mja9	10	14	System	System	NNP
cord-006702-ekf6mja9	10	15	(	(	-LRB-
cord-006702-ekf6mja9	10	16	RAS	RAS	NNP
cord-006702-ekf6mja9	10	17	)	)	-RRB-
cord-006702-ekf6mja9	10	18	might	may	MD
cord-006702-ekf6mja9	10	19	take	take	VB
cord-006702-ekf6mja9	10	20	part	part	NN
cord-006702-ekf6mja9	10	21	in	in	IN
cord-006702-ekf6mja9	10	22	renal	renal	JJ
cord-006702-ekf6mja9	10	23	damage	damage	NN
cord-006702-ekf6mja9	10	24	observed	observe	VBN
cord-006702-ekf6mja9	10	25	in	in	IN
cord-006702-ekf6mja9	10	26	other	other	JJ
cord-006702-ekf6mja9	10	27	obstructive	obstructive	JJ
cord-006702-ekf6mja9	10	28	nephropathies	nephropathy	NNS
cord-006702-ekf6mja9	10	29	.	.	.
cord-006702-ekf6mja9	11	1	The	the	DT
cord-006702-ekf6mja9	11	2	aim	aim	NN
cord-006702-ekf6mja9	11	3	of	of	IN
cord-006702-ekf6mja9	11	4	this	this	DT
cord-006702-ekf6mja9	11	5	study	study	NN
cord-006702-ekf6mja9	11	6	was	be	VBD
cord-006702-ekf6mja9	11	7	to	to	TO
cord-006702-ekf6mja9	11	8	evaluate	evaluate	VB
cord-006702-ekf6mja9	11	9	if	if	IN
cord-006702-ekf6mja9	11	10	molecules	molecule	NNS
cord-006702-ekf6mja9	11	11	related	relate	VBN
cord-006702-ekf6mja9	11	12	to	to	IN
cord-006702-ekf6mja9	11	13	inflammation	inflammation	NN
cord-006702-ekf6mja9	11	14	and	and	CC
cord-006702-ekf6mja9	11	15	components	component	NNS
cord-006702-ekf6mja9	11	16	of	of	IN
cord-006702-ekf6mja9	11	17	the	the	DT
cord-006702-ekf6mja9	11	18	RAS	RAS	NNP
cord-006702-ekf6mja9	11	19	can	can	MD
cord-006702-ekf6mja9	11	20	be	be	VB
cord-006702-ekf6mja9	11	21	detected	detect	VBN
cord-006702-ekf6mja9	11	22	in	in	IN
cord-006702-ekf6mja9	11	23	the	the	DT
cord-006702-ekf6mja9	11	24	urine	urine	NN
cord-006702-ekf6mja9	11	25	from	from	IN
cord-006702-ekf6mja9	11	26	fetuses	fetus	NNS
cord-006702-ekf6mja9	11	27	with	with	IN
cord-006702-ekf6mja9	11	28	posterior	posterior	JJ
cord-006702-ekf6mja9	11	29	urethral	urethral	JJ
cord-006702-ekf6mja9	11	30	valve	valve	NN
cord-006702-ekf6mja9	11	31	(	(	-LRB-
cord-006702-ekf6mja9	11	32	PUV	PUV	NNP
cord-006702-ekf6mja9	11	33	)	)	-RRB-
cord-006702-ekf6mja9	11	34	and	and	CC
cord-006702-ekf6mja9	11	35	if	if	IN
cord-006702-ekf6mja9	11	36	these	these	DT
cord-006702-ekf6mja9	11	37	biomarkers	biomarker	NNS
cord-006702-ekf6mja9	11	38	are	be	VBP
cord-006702-ekf6mja9	11	39	associated	associate	VBN
cord-006702-ekf6mja9	11	40	with	with	IN
cord-006702-ekf6mja9	11	41	the	the	DT
cord-006702-ekf6mja9	11	42	pathogenesis	pathogenesis	NN
cord-006702-ekf6mja9	11	43	of	of	IN
cord-006702-ekf6mja9	11	44	this	this	DT
cord-006702-ekf6mja9	11	45	congenital	congenital	JJ
cord-006702-ekf6mja9	11	46	anomaly	anomaly	NN
cord-006702-ekf6mja9	11	47	.	.	.
cord-006702-ekf6mja9	12	1	Methods	method	NNS
cord-006702-ekf6mja9	12	2	:	:	:
cord-006702-ekf6mja9	12	3	Urine	urine	NN
cord-006702-ekf6mja9	12	4	samples	sample	NNS
cord-006702-ekf6mja9	12	5	from	from	IN
cord-006702-ekf6mja9	12	6	24	24	CD
cord-006702-ekf6mja9	12	7	fetuses	fetus	NNS
cord-006702-ekf6mja9	12	8	with	with	IN
cord-006702-ekf6mja9	12	9	PUV	PUV	NNP
cord-006702-ekf6mja9	12	10	at	at	IN
cord-006702-ekf6mja9	12	11	a	a	DT
cord-006702-ekf6mja9	12	12	mean	mean	JJ
cord-006702-ekf6mja9	12	13	gestational	gestational	JJ
cord-006702-ekf6mja9	12	14	age	age	NN
cord-006702-ekf6mja9	12	15	of	of	IN
cord-006702-ekf6mja9	12	16	22	22	CD
cord-006702-ekf6mja9	12	17	weeks	week	NNS
cord-006702-ekf6mja9	12	18	(	(	-LRB-
cord-006702-ekf6mja9	12	19	16	16	CD
cord-006702-ekf6mja9	12	20	-	-	HYPH
cord-006702-ekf6mja9	12	21	33w	33w	NNPS
cord-006702-ekf6mja9	12	22	)	)	-RRB-
cord-006702-ekf6mja9	12	23	were	be	VBD
cord-006702-ekf6mja9	12	24	collected	collect	VBN
cord-006702-ekf6mja9	12	25	and	and	CC
cord-006702-ekf6mja9	12	26	compared	compare	VBN
cord-006702-ekf6mja9	12	27	to	to	IN
cord-006702-ekf6mja9	12	28	urine	urine	NN
cord-006702-ekf6mja9	12	29	samples	sample	NNS
cord-006702-ekf6mja9	12	30	from	from	IN
cord-006702-ekf6mja9	12	31	37	37	CD
cord-006702-ekf6mja9	12	32	healthy	healthy	JJ
cord-006702-ekf6mja9	12	33	male	male	JJ
cord-006702-ekf6mja9	12	34	newborns	newborn	NNS
cord-006702-ekf6mja9	12	35	(	(	-LRB-
cord-006702-ekf6mja9	12	36	control	control	NN
cord-006702-ekf6mja9	12	37	group	group	NN
cord-006702-ekf6mja9	12	38	)	)	-RRB-
cord-006702-ekf6mja9	12	39	.	.	.
cord-006702-ekf6mja9	13	1	Cytokines	cytokine	NNS
cord-006702-ekf6mja9	13	2	,	,	,
cord-006702-ekf6mja9	13	3	chemokines	chemokine	NNS
cord-006702-ekf6mja9	13	4	and	and	CC
cord-006702-ekf6mja9	13	5	RAS	RAS	NNP
cord-006702-ekf6mja9	13	6	components	component	NNS
cord-006702-ekf6mja9	13	7	levels	level	NNS
cord-006702-ekf6mja9	13	8	were	be	VBD
cord-006702-ekf6mja9	13	9	measured	measure	VBN
cord-006702-ekf6mja9	13	10	by	by	IN
cord-006702-ekf6mja9	13	11	cytometric	cytometric	NNP
cord-006702-ekf6mja9	13	12	bead	bead	NN
cord-006702-ekf6mja9	13	13	array	array	NN
cord-006702-ekf6mja9	13	14	(	(	-LRB-
cord-006702-ekf6mja9	13	15	CBA	CBA	NNP
cord-006702-ekf6mja9	13	16	)	)	-RRB-
cord-006702-ekf6mja9	13	17	and	and	CC
cord-006702-ekf6mja9	13	18	enzyme	enzyme	NN
cord-006702-ekf6mja9	13	19	-	-	HYPH
cord-006702-ekf6mja9	13	20	linked	link	VBN
cord-006702-ekf6mja9	13	21	immunosorbent	immunosorbent	JJ
cord-006702-ekf6mja9	13	22	assay	assay	NN
cord-006702-ekf6mja9	13	23	(	(	-LRB-
cord-006702-ekf6mja9	13	24	ELISA	ELISA	NNP
cord-006702-ekf6mja9	13	25	)	)	-RRB-
cord-006702-ekf6mja9	13	26	.	.	.
cord-006702-ekf6mja9	14	1	Results	result	NNS
cord-006702-ekf6mja9	14	2	:	:	:
cord-006702-ekf6mja9	15	1	In	in	IN
cord-006702-ekf6mja9	15	2	comparison	comparison	NN
cord-006702-ekf6mja9	15	3	to	to	IN
cord-006702-ekf6mja9	15	4	healthy	healthy	JJ
cord-006702-ekf6mja9	15	5	male	male	JJ
cord-006702-ekf6mja9	15	6	newborns	newborn	NNS
cord-006702-ekf6mja9	15	7	,	,	,
cord-006702-ekf6mja9	15	8	fetuses	fetus	NNS
cord-006702-ekf6mja9	15	9	with	with	IN
cord-006702-ekf6mja9	15	10	PUV	PUV	NNP
cord-006702-ekf6mja9	15	11	had	have	VBD
cord-006702-ekf6mja9	15	12	significantly	significantly	RB
cord-006702-ekf6mja9	15	13	increased	increase	VBN
cord-006702-ekf6mja9	15	14	urinary	urinary	JJ
cord-006702-ekf6mja9	15	15	levels	level	NNS
cord-006702-ekf6mja9	15	16	of	of	IN
cord-006702-ekf6mja9	15	17	IL-2	IL-2	NNP
cord-006702-ekf6mja9	15	18	(	(	-LRB-
cord-006702-ekf6mja9	15	19	p<0,0001	p<0,0001	NNP
cord-006702-ekf6mja9	15	20	)	)	-RRB-
cord-006702-ekf6mja9	15	21	,	,	,
cord-006702-ekf6mja9	15	22	IL-4	IL-4	NNP
cord-006702-ekf6mja9	15	23	(	(	-LRB-
cord-006702-ekf6mja9	15	24	p<0,0001	p<0,0001	NNP
cord-006702-ekf6mja9	15	25	)	)	-RRB-
cord-006702-ekf6mja9	15	26	,	,	,
cord-006702-ekf6mja9	15	27	IL-6	IL-6	NNP
cord-006702-ekf6mja9	15	28	(	(	-LRB-
cord-006702-ekf6mja9	15	29	p=0,0022	p=0,0022	UH
cord-006702-ekf6mja9	15	30	)	)	-RRB-
cord-006702-ekf6mja9	15	31	,	,	,
cord-006702-ekf6mja9	15	32	IL-10	IL-10	NNP
cord-006702-ekf6mja9	15	33	(	(	-LRB-
cord-006702-ekf6mja9	15	34	p<0,0001	p<0,0001	NNP
cord-006702-ekf6mja9	15	35	)	)	-RRB-
cord-006702-ekf6mja9	15	36	,	,	,
cord-006702-ekf6mja9	15	37	IFN	IFN	NNP
cord-006702-ekf6mja9	15	38	-	-	HYPH
cord-006702-ekf6mja9	15	39	γ(p<0,0001	γ(p<0,0001	NNP
cord-006702-ekf6mja9	15	40	)	)	-RRB-
cord-006702-ekf6mja9	15	41	,	,	,
cord-006702-ekf6mja9	15	42	eotaxin	eotaxin	NNP
cord-006702-ekf6mja9	15	43	(	(	-LRB-
cord-006702-ekf6mja9	15	44	p<0,0001	p<0,0001	NNP
cord-006702-ekf6mja9	15	45	)	)	-RRB-
cord-006702-ekf6mja9	15	46	,	,	,
cord-006702-ekf6mja9	15	47	MCP-1	MCP-1	NNP
cord-006702-ekf6mja9	15	48	(	(	-LRB-
cord-006702-ekf6mja9	15	49	p=0,005	p=0,005	NNP
cord-006702-ekf6mja9	15	50	)	)	-RRB-
cord-006702-ekf6mja9	15	51	,	,	,
cord-006702-ekf6mja9	15	52	soluble	soluble	JJ
cord-006702-ekf6mja9	15	53	receptors	receptor	NNS
cord-006702-ekf6mja9	15	54	of	of	IN
cord-006702-ekf6mja9	15	55	TNF	TNF	NNP
cord-006702-ekf6mja9	15	56	type	type	NN
cord-006702-ekf6mja9	15	57	1	1	CD
cord-006702-ekf6mja9	15	58	(	(	-LRB-
cord-006702-ekf6mja9	15	59	p=0,0002	p=0,0002	NNP
cord-006702-ekf6mja9	15	60	)	)	-RRB-
cord-006702-ekf6mja9	15	61	and	and	CC
cord-006702-ekf6mja9	15	62	type	type	NN
cord-006702-ekf6mja9	15	63	2	2	CD
cord-006702-ekf6mja9	15	64	(	(	-LRB-
cord-006702-ekf6mja9	15	65	p=0,0004	p=0,0004	NNP
cord-006702-ekf6mja9	15	66	)	)	-RRB-
cord-006702-ekf6mja9	15	67	.	.	.
cord-006702-ekf6mja9	16	1	This	this	DT
cord-006702-ekf6mja9	16	2	intense	intense	JJ
cord-006702-ekf6mja9	16	3	elevation	elevation	NN
cord-006702-ekf6mja9	16	4	of	of	IN
cord-006702-ekf6mja9	16	5	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	16	6	molecules	molecule	NNS
cord-006702-ekf6mja9	16	7	was	be	VBD
cord-006702-ekf6mja9	16	8	accompanied	accompany	VBN
cord-006702-ekf6mja9	16	9	by	by	IN
cord-006702-ekf6mja9	16	10	significantly	significantly	RB
cord-006702-ekf6mja9	16	11	increased	increase	VBN
cord-006702-ekf6mja9	16	12	urinary	urinary	JJ
cord-006702-ekf6mja9	16	13	levels	level	NNS
cord-006702-ekf6mja9	16	14	of	of	IN
cord-006702-ekf6mja9	16	15	Angiotensin	angiotensin	NN
cord-006702-ekf6mja9	16	16	I	i	NN
cord-006702-ekf6mja9	16	17	(	(	-LRB-
cord-006702-ekf6mja9	16	18	p=0,0017	p=0,0017	NNP
cord-006702-ekf6mja9	16	19	)	)	-RRB-
cord-006702-ekf6mja9	16	20	,	,	,
cord-006702-ekf6mja9	16	21	Angiotensin-(1	Angiotensin-(1	NNP
cord-006702-ekf6mja9	16	22	-	-	HYPH
cord-006702-ekf6mja9	16	23	7	7	CD
cord-006702-ekf6mja9	16	24	)	)	-RRB-
cord-006702-ekf6mja9	16	25	(	(	-LRB-
cord-006702-ekf6mja9	16	26	p<0,0001	p<0,0001	NNP
cord-006702-ekf6mja9	16	27	)	)	-RRB-
cord-006702-ekf6mja9	16	28	,	,	,
cord-006702-ekf6mja9	16	29	and	and	CC
cord-006702-ekf6mja9	16	30	ACE	ace	NN
cord-006702-ekf6mja9	16	31	2	2	CD
cord-006702-ekf6mja9	16	32	(	(	-LRB-
cord-006702-ekf6mja9	16	33	p<0,0001	p<0,0001	NN
cord-006702-ekf6mja9	16	34	)	)	-RRB-
cord-006702-ekf6mja9	16	35	.	.	.
cord-006702-ekf6mja9	17	1	On	on	IN
cord-006702-ekf6mja9	17	2	the	the	DT
cord-006702-ekf6mja9	17	3	other	other	JJ
cord-006702-ekf6mja9	17	4	hand	hand	NN
cord-006702-ekf6mja9	17	5	,	,	,
cord-006702-ekf6mja9	17	6	ACE	ace	NN
cord-006702-ekf6mja9	17	7	concentrations	concentration	NNS
cord-006702-ekf6mja9	17	8	were	be	VBD
cord-006702-ekf6mja9	17	9	significantly	significantly	RB
cord-006702-ekf6mja9	17	10	reduced	reduce	VBN
cord-006702-ekf6mja9	17	11	and	and	CC
cord-006702-ekf6mja9	18	1	Angiotensin	angiotensin	NN
cord-006702-ekf6mja9	18	2	II	ii	CD
cord-006702-ekf6mja9	18	3	levels	level	NNS
cord-006702-ekf6mja9	18	4	were	be	VBD
cord-006702-ekf6mja9	18	5	similar	similar	JJ
cord-006702-ekf6mja9	18	6	when	when	WRB
cord-006702-ekf6mja9	18	7	compared	compare	VBN
cord-006702-ekf6mja9	18	8	to	to	TO
cord-006702-ekf6mja9	18	9	control	control	NN
cord-006702-ekf6mja9	18	10	group	group	NN
cord-006702-ekf6mja9	18	11	.	.	.
cord-006702-ekf6mja9	19	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	19	2	:	:	:
cord-006702-ekf6mja9	20	1	The	the	DT
cord-006702-ekf6mja9	20	2	increased	increase	VBN
cord-006702-ekf6mja9	20	3	levels	level	NNS
cord-006702-ekf6mja9	20	4	of	of	IN
cord-006702-ekf6mja9	20	5	cytokines	cytokine	NNS
cord-006702-ekf6mja9	20	6	and	and	CC
cord-006702-ekf6mja9	20	7	chemokines	chemokine	NNS
cord-006702-ekf6mja9	20	8	suggest	suggest	VBP
cord-006702-ekf6mja9	20	9	that	that	IN
cord-006702-ekf6mja9	20	10	PUV	PUV	NNP
cord-006702-ekf6mja9	20	11	leads	lead	VBZ
cord-006702-ekf6mja9	20	12	to	to	IN
cord-006702-ekf6mja9	20	13	a	a	DT
cord-006702-ekf6mja9	20	14	pro	pro	JJ
cord-006702-ekf6mja9	20	15	-	-	JJ
cord-006702-ekf6mja9	20	16	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	20	17	state	state	NN
cord-006702-ekf6mja9	20	18	that	that	WDT
cord-006702-ekf6mja9	20	19	might	may	MD
cord-006702-ekf6mja9	20	20	be	be	VB
cord-006702-ekf6mja9	20	21	part	part	NN
cord-006702-ekf6mja9	20	22	of	of	IN
cord-006702-ekf6mja9	20	23	the	the	DT
cord-006702-ekf6mja9	20	24	pathophysiology	pathophysiology	NN
cord-006702-ekf6mja9	20	25	of	of	IN
cord-006702-ekf6mja9	20	26	this	this	DT
cord-006702-ekf6mja9	20	27	anomaly	anomaly	NN
cord-006702-ekf6mja9	20	28	.	.	.
cord-006702-ekf6mja9	21	1	The	the	DT
cord-006702-ekf6mja9	21	2	observed	observed	JJ
cord-006702-ekf6mja9	21	3	activation	activation	NN
cord-006702-ekf6mja9	21	4	of	of	IN
cord-006702-ekf6mja9	21	5	the	the	DT
cord-006702-ekf6mja9	21	6	protective	protective	JJ
cord-006702-ekf6mja9	21	7	arm	arm	NN
cord-006702-ekf6mja9	21	8	of	of	IN
cord-006702-ekf6mja9	21	9	the	the	DT
cord-006702-ekf6mja9	21	10	RAS	RAS	NNP
cord-006702-ekf6mja9	21	11	,	,	,
cord-006702-ekf6mja9	21	12	formed	form	VBN
cord-006702-ekf6mja9	21	13	by	by	IN
cord-006702-ekf6mja9	21	14	ACE2-Angiotensin-(1	ACE2-Angiotensin-(1	NNP
cord-006702-ekf6mja9	21	15	-	-	HYPH
cord-006702-ekf6mja9	21	16	7)-Mas	7)-mas	CD
cord-006702-ekf6mja9	21	17	receptor	receptor	NN
cord-006702-ekf6mja9	21	18	,	,	,
cord-006702-ekf6mja9	21	19	may	may	MD
cord-006702-ekf6mja9	21	20	play	play	VB
cord-006702-ekf6mja9	21	21	a	a	DT
cord-006702-ekf6mja9	21	22	role	role	NN
cord-006702-ekf6mja9	21	23	in	in	IN
cord-006702-ekf6mja9	21	24	modulating	modulate	VBG
cord-006702-ekf6mja9	21	25	the	the	DT
cord-006702-ekf6mja9	21	26	intense	intense	JJ
cord-006702-ekf6mja9	21	27	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	21	28	process	process	NN
cord-006702-ekf6mja9	21	29	triggered	trigger	VBN
cord-006702-ekf6mja9	21	30	by	by	IN
cord-006702-ekf6mja9	21	31	PUV	PUV	NNP
cord-006702-ekf6mja9	21	32	.	.	.
cord-006702-ekf6mja9	22	1	Objectives	objective	NNS
cord-006702-ekf6mja9	22	2	:	:	:
cord-006702-ekf6mja9	22	3	To	to	TO
cord-006702-ekf6mja9	22	4	compare	compare	VB
cord-006702-ekf6mja9	22	5	outcomes	outcome	NNS
cord-006702-ekf6mja9	22	6	of	of	IN
cord-006702-ekf6mja9	22	7	patients	patient	NNS
cord-006702-ekf6mja9	22	8	(	(	-LRB-
cord-006702-ekf6mja9	22	9	pts	pt	NNS
cord-006702-ekf6mja9	22	10	)	)	-RRB-
cord-006702-ekf6mja9	22	11	with	with	IN
cord-006702-ekf6mja9	22	12	LUTO	LUTO	NNP
cord-006702-ekf6mja9	22	13	stratified	stratify	VBN
cord-006702-ekf6mja9	22	14	by	by	IN
cord-006702-ekf6mja9	22	15	severity	severity	NN
cord-006702-ekf6mja9	22	16	using	use	VBG
cord-006702-ekf6mja9	22	17	a	a	DT
cord-006702-ekf6mja9	22	18	prenatal	prenatal	JJ
cord-006702-ekf6mja9	22	19	classification	classification	NN
cord-006702-ekf6mja9	22	20	system	system	NN
cord-006702-ekf6mja9	22	21	.	.	.
cord-006702-ekf6mja9	23	1	Methods	method	NNS
cord-006702-ekf6mja9	23	2	:	:	:
cord-006702-ekf6mja9	24	1	Retrospective	retrospective	JJ
cord-006702-ekf6mja9	24	2	chart	chart	NN
cord-006702-ekf6mja9	24	3	review	review	NN
cord-006702-ekf6mja9	24	4	of	of	IN
cord-006702-ekf6mja9	24	5	LUTO	LUTO	NNP
cord-006702-ekf6mja9	24	6	cases	case	NNS
cord-006702-ekf6mja9	24	7	evaluated	evaluate	VBN
cord-006702-ekf6mja9	24	8	at	at	IN
cord-006702-ekf6mja9	24	9	the	the	DT
cord-006702-ekf6mja9	24	10	Texas	Texas	NNP
cord-006702-ekf6mja9	24	11	Children	Children	NNP
cord-006702-ekf6mja9	24	12	's	's	POS
cord-006702-ekf6mja9	24	13	Hospital	Hospital	NNP
cord-006702-ekf6mja9	24	14	Fetal	Fetal	NNP
cord-006702-ekf6mja9	24	15	Center	Center	NNP
cord-006702-ekf6mja9	24	16	from	from	IN
cord-006702-ekf6mja9	24	17	2012	2012	CD
cord-006702-ekf6mja9	24	18	-	-	SYM
cord-006702-ekf6mja9	24	19	2015	2015	CD
cord-006702-ekf6mja9	24	20	.	.	.
cord-006702-ekf6mja9	25	1	LUTO	LUTO	NNP
cord-006702-ekf6mja9	25	2	classification	classification	NN
cord-006702-ekf6mja9	25	3	:	:	:
cord-006702-ekf6mja9	26	1	Stage	stage	NN
cord-006702-ekf6mja9	26	2	I	-PRON-	PRP
cord-006702-ekf6mja9	26	3	:	:	:
cord-006702-ekf6mja9	26	4	normal	normal	JJ
cord-006702-ekf6mja9	26	5	amniotic	amniotic	NN
cord-006702-ekf6mja9	26	6	fluid	fluid	JJ
cord-006702-ekf6mja9	26	7	level	level	NN
cord-006702-ekf6mja9	26	8	(	(	-LRB-
cord-006702-ekf6mja9	26	9	>	>	NFP
cord-006702-ekf6mja9	26	10	18wks	18wks	LS
cord-006702-ekf6mja9	26	11	gestation	gestation	NN
cord-006702-ekf6mja9	26	12	)	)	-RRB-
cord-006702-ekf6mja9	26	13	,	,	,
cord-006702-ekf6mja9	26	14	favorable	favorable	JJ
cord-006702-ekf6mja9	26	15	fetal	fetal	JJ
cord-006702-ekf6mja9	26	16	urinary	urinary	JJ
cord-006702-ekf6mja9	26	17	indices	index	NNS
cord-006702-ekf6mja9	26	18	*	*	NFP
cord-006702-ekf6mja9	26	19	,	,	,
cord-006702-ekf6mja9	26	20	absence	absence	NN
cord-006702-ekf6mja9	26	21	of	of	IN
cord-006702-ekf6mja9	26	22	renal	renal	JJ
cord-006702-ekf6mja9	26	23	cysts	cyst	NNS
cord-006702-ekf6mja9	26	24	or	or	CC
cord-006702-ekf6mja9	26	25	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	26	26	;	;	:
cord-006702-ekf6mja9	26	27	Stage	stage	NN
cord-006702-ekf6mja9	26	28	II	II	NNP
cord-006702-ekf6mja9	26	29	:	:	:
cord-006702-ekf6mja9	26	30	oligohydramnios	oligohydramnios	NNP
cord-006702-ekf6mja9	26	31	(	(	-LRB-
cord-006702-ekf6mja9	26	32	>	>	XX
cord-006702-ekf6mja9	26	33	18wks	18wks	LS
cord-006702-ekf6mja9	26	34	)	)	-RRB-
cord-006702-ekf6mja9	26	35	,	,	,
cord-006702-ekf6mja9	26	36	severe	severe	JJ
cord-006702-ekf6mja9	26	37	bilateral	bilateral	JJ
cord-006702-ekf6mja9	26	38	hydronephrosis	hydronephrosis	NN
cord-006702-ekf6mja9	26	39	,	,	,
cord-006702-ekf6mja9	26	40	favorable	favorable	JJ
cord-006702-ekf6mja9	26	41	urinary	urinary	JJ
cord-006702-ekf6mja9	26	42	indices	index	NNS
cord-006702-ekf6mja9	26	43	,	,	,
cord-006702-ekf6mja9	26	44	absence	absence	NN
cord-006702-ekf6mja9	26	45	of	of	IN
cord-006702-ekf6mja9	26	46	renal	renal	JJ
cord-006702-ekf6mja9	26	47	cysts	cyst	NNS
cord-006702-ekf6mja9	26	48	or	or	CC
cord-006702-ekf6mja9	26	49	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	26	50	;	;	:
cord-006702-ekf6mja9	26	51	Stage	stage	NN
cord-006702-ekf6mja9	26	52	III	III	NNP
cord-006702-ekf6mja9	26	53	:	:	:
cord-006702-ekf6mja9	27	1	oligohydramnios	oligohydramnios	NNP
cord-006702-ekf6mja9	27	2	(	(	-LRB-
cord-006702-ekf6mja9	27	3	>	>	XX
cord-006702-ekf6mja9	27	4	18wks	18wks	LS
cord-006702-ekf6mja9	27	5	)	)	-RRB-
cord-006702-ekf6mja9	27	6	,	,	,
cord-006702-ekf6mja9	27	7	severe	severe	JJ
cord-006702-ekf6mja9	27	8	bilateral	bilateral	JJ
cord-006702-ekf6mja9	27	9	hydronephrosis	hydronephrosis	NN
cord-006702-ekf6mja9	27	10	,	,	,
cord-006702-ekf6mja9	27	11	unfavorable	unfavorable	JJ
cord-006702-ekf6mja9	27	12	urinary	urinary	JJ
cord-006702-ekf6mja9	27	13	indices	index	NNS
cord-006702-ekf6mja9	27	14	,	,	,
cord-006702-ekf6mja9	27	15	presence	presence	NN
cord-006702-ekf6mja9	27	16	of	of	IN
cord-006702-ekf6mja9	27	17	renal	renal	JJ
cord-006702-ekf6mja9	27	18	cysts	cyst	NNS
cord-006702-ekf6mja9	27	19	or	or	CC
cord-006702-ekf6mja9	27	20	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	27	21	.	.	.
cord-006702-ekf6mja9	28	1	*	*	NFP
cord-006702-ekf6mja9	28	2	Favorable	favorable	JJ
cord-006702-ekf6mja9	28	3	fetal	fetal	JJ
cord-006702-ekf6mja9	28	4	urinary	urinary	JJ
cord-006702-ekf6mja9	28	5	indices	index	NNS
cord-006702-ekf6mja9	28	6	:	:	:
cord-006702-ekf6mja9	29	1	Na	Na	NNP
cord-006702-ekf6mja9	30	1	<	<	NNP
cord-006702-ekf6mja9	30	2	100mEq	100mEq	NNP
cord-006702-ekf6mja9	30	3	/	/	SYM
cord-006702-ekf6mja9	30	4	L	L	NNP
cord-006702-ekf6mja9	30	5	,	,	,
cord-006702-ekf6mja9	30	6	Chloride	chloride	NN
cord-006702-ekf6mja9	30	7	<	<	XX
cord-006702-ekf6mja9	30	8	90	90	CD
cord-006702-ekf6mja9	30	9	mEq	mEq	NNS
cord-006702-ekf6mja9	30	10	/	/	SYM
cord-006702-ekf6mja9	30	11	L	L	NNP
cord-006702-ekf6mja9	30	12	,	,	,
cord-006702-ekf6mja9	30	13	Osm	Osm	NNP
cord-006702-ekf6mja9	30	14	<	<	XX
cord-006702-ekf6mja9	30	15	200	200	CD
cord-006702-ekf6mja9	30	16	mOsm	mOsm	NNP
cord-006702-ekf6mja9	30	17	/	/	SYM
cord-006702-ekf6mja9	30	18	L	l	NN
cord-006702-ekf6mja9	30	19	,	,	,
cord-006702-ekf6mja9	30	20	β2-microglobulin	β2-microglobulin	XX
cord-006702-ekf6mja9	30	21	<	<	XX
cord-006702-ekf6mja9	30	22	6mg/	6mg/	CD
cord-006702-ekf6mja9	31	1	L	L	NNP
cord-006702-ekf6mja9	31	2	Results	result	NNS
cord-006702-ekf6mja9	31	3	:	:	:
cord-006702-ekf6mja9	32	1	42	42	CD
cord-006702-ekf6mja9	32	2	total	total	JJ
cord-006702-ekf6mja9	32	3	LUTO	LUTO	NNS
cord-006702-ekf6mja9	32	4	cases	case	NNS
cord-006702-ekf6mja9	32	5	were	be	VBD
cord-006702-ekf6mja9	32	6	seen	see	VBN
cord-006702-ekf6mja9	32	7	in	in	IN
cord-006702-ekf6mja9	32	8	the	the	DT
cord-006702-ekf6mja9	32	9	study	study	NN
cord-006702-ekf6mja9	32	10	period	period	NN
cord-006702-ekf6mja9	32	11	.	.	.
cord-006702-ekf6mja9	33	1	Five	five	CD
cord-006702-ekf6mja9	33	2	underwent	undergo	VBD
cord-006702-ekf6mja9	33	3	termination	termination	NN
cord-006702-ekf6mja9	33	4	of	of	IN
cord-006702-ekf6mja9	33	5	pregnancy	pregnancy	NN
cord-006702-ekf6mja9	33	6	and	and	CC
cord-006702-ekf6mja9	33	7	1	1	CD
cord-006702-ekf6mja9	33	8	had	have	VBD
cord-006702-ekf6mja9	33	9	intrauterine	intrauterine	JJ
cord-006702-ekf6mja9	33	10	fetal	fetal	JJ
cord-006702-ekf6mja9	33	11	demise	demise	NN
cord-006702-ekf6mja9	33	12	.	.	.
cord-006702-ekf6mja9	34	1	Therefore	therefore	RB
cord-006702-ekf6mja9	34	2	,	,	,
cord-006702-ekf6mja9	34	3	36	36	CD
cord-006702-ekf6mja9	34	4	pts	pt	NNS
cord-006702-ekf6mja9	34	5	were	be	VBD
cord-006702-ekf6mja9	34	6	evaluated	evaluate	VBN
cord-006702-ekf6mja9	34	7	:	:	:
cord-006702-ekf6mja9	34	8	6	6	CD
cord-006702-ekf6mja9	34	9	stage	stage	NN
cord-006702-ekf6mja9	34	10	I	-PRON-	PRP
cord-006702-ekf6mja9	34	11	,	,	,
cord-006702-ekf6mja9	34	12	18	18	CD
cord-006702-ekf6mja9	34	13	stage	stage	NN
cord-006702-ekf6mja9	34	14	II	II	NNP
cord-006702-ekf6mja9	34	15	and	and	CC
cord-006702-ekf6mja9	34	16	12	12	CD
cord-006702-ekf6mja9	34	17	stage	stage	NN
cord-006702-ekf6mja9	34	18	3	3	CD
cord-006702-ekf6mja9	34	19	.	.	.
cord-006702-ekf6mja9	35	1	No	no	DT
cord-006702-ekf6mja9	35	2	pts	pts	NN
cord-006702-ekf6mja9	35	3	with	with	IN
cord-006702-ekf6mja9	35	4	stage	stage	NN
cord-006702-ekf6mja9	36	1	I	-PRON-	PRP
cord-006702-ekf6mja9	36	2	LUTO	luto	VBP
cord-006702-ekf6mja9	36	3	had	have	VBD
cord-006702-ekf6mja9	36	4	fetal	fetal	JJ
cord-006702-ekf6mja9	36	5	intervention	intervention	NN
cord-006702-ekf6mja9	36	6	,	,	,
cord-006702-ekf6mja9	36	7	while	while	IN
cord-006702-ekf6mja9	36	8	100	100	CD
cord-006702-ekf6mja9	36	9	%	%	NN
cord-006702-ekf6mja9	36	10	of	of	IN
cord-006702-ekf6mja9	36	11	stage	stage	NN
cord-006702-ekf6mja9	36	12	II	II	NNP
cord-006702-ekf6mja9	36	13	and	and	CC
cord-006702-ekf6mja9	36	14	25	25	CD
cord-006702-ekf6mja9	36	15	%	%	NN
cord-006702-ekf6mja9	36	16	of	of	IN
cord-006702-ekf6mja9	36	17	stage	stage	NN
cord-006702-ekf6mja9	36	18	III	iii	CD
cord-006702-ekf6mja9	36	19	underwent	undergo	VBD
cord-006702-ekf6mja9	36	20	vesicoamniotic	vesicoamniotic	JJ
cord-006702-ekf6mja9	36	21	shunting	shunting	NN
cord-006702-ekf6mja9	36	22	.	.	.
cord-006702-ekf6mja9	37	1	Gestational	gestational	JJ
cord-006702-ekf6mja9	37	2	age	age	NN
cord-006702-ekf6mja9	37	3	at	at	IN
cord-006702-ekf6mja9	37	4	delivery	delivery	NN
cord-006702-ekf6mja9	37	5	and	and	CC
cord-006702-ekf6mja9	37	6	birth	birth	NN
cord-006702-ekf6mja9	37	7	weight	weight	NN
cord-006702-ekf6mja9	37	8	were	be	VBD
cord-006702-ekf6mja9	37	9	similar	similar	JJ
cord-006702-ekf6mja9	37	10	between	between	IN
cord-006702-ekf6mja9	37	11	the	the	DT
cord-006702-ekf6mja9	37	12	groups	group	NNS
cord-006702-ekf6mja9	37	13	.	.	.
cord-006702-ekf6mja9	38	1	A	a	DT
cord-006702-ekf6mja9	38	2	greater	great	JJR
cord-006702-ekf6mja9	38	3	percentage	percentage	NN
cord-006702-ekf6mja9	38	4	of	of	IN
cord-006702-ekf6mja9	38	5	neonatal	neonatal	JJ
cord-006702-ekf6mja9	38	6	deaths	death	NNS
cord-006702-ekf6mja9	38	7	occurred	occur	VBD
cord-006702-ekf6mja9	38	8	in	in	IN
cord-006702-ekf6mja9	38	9	the	the	DT
cord-006702-ekf6mja9	38	10	stage	stage	NN
cord-006702-ekf6mja9	38	11	III	iii	CD
cord-006702-ekf6mja9	38	12	group	group	NN
cord-006702-ekf6mja9	38	13	(	(	-LRB-
cord-006702-ekf6mja9	38	14	67	67	CD
cord-006702-ekf6mja9	38	15	%	%	NN
cord-006702-ekf6mja9	38	16	)	)	-RRB-
cord-006702-ekf6mja9	38	17	compared	compare	VBN
cord-006702-ekf6mja9	38	18	with	with	IN
cord-006702-ekf6mja9	38	19	stage	stage	NN
cord-006702-ekf6mja9	38	20	II	II	NNP
cord-006702-ekf6mja9	38	21	(	(	-LRB-
cord-006702-ekf6mja9	38	22	17	17	CD
cord-006702-ekf6mja9	38	23	%	%	NN
cord-006702-ekf6mja9	38	24	)	)	-RRB-
cord-006702-ekf6mja9	38	25	or	or	CC
cord-006702-ekf6mja9	38	26	stage	stage	NN
cord-006702-ekf6mja9	38	27	I	-PRON-	PRP
cord-006702-ekf6mja9	38	28	(	(	-LRB-
cord-006702-ekf6mja9	38	29	0	0	CD
cord-006702-ekf6mja9	38	30	%	%	NN
cord-006702-ekf6mja9	38	31	)	)	-RRB-
cord-006702-ekf6mja9	38	32	.	.	.
cord-006702-ekf6mja9	39	1	75	75	CD
cord-006702-ekf6mja9	39	2	%	%	NN
cord-006702-ekf6mja9	39	3	of	of	IN
cord-006702-ekf6mja9	39	4	surviving	survive	VBG
cord-006702-ekf6mja9	39	5	stage	stage	NN
cord-006702-ekf6mja9	39	6	III	iii	CD
cord-006702-ekf6mja9	39	7	pts	pt	NNS
cord-006702-ekf6mja9	39	8	required	require	VBN
cord-006702-ekf6mja9	39	9	dialysis	dialysis	NN
cord-006702-ekf6mja9	39	10	as	as	IN
cord-006702-ekf6mja9	39	11	neonates	neonate	NNS
cord-006702-ekf6mja9	39	12	,	,	,
cord-006702-ekf6mja9	39	13	and	and	CC
cord-006702-ekf6mja9	39	14	100	100	CD
cord-006702-ekf6mja9	39	15	%	%	NN
cord-006702-ekf6mja9	39	16	were	be	VBD
cord-006702-ekf6mja9	39	17	dialysis	dialysis	NN
cord-006702-ekf6mja9	39	18	dependent	dependent	JJ
cord-006702-ekf6mja9	39	19	by	by	IN
cord-006702-ekf6mja9	39	20	1yr	1yr	NN
cord-006702-ekf6mja9	39	21	of	of	IN
cord-006702-ekf6mja9	39	22	age	age	NN
cord-006702-ekf6mja9	39	23	.	.	.
cord-006702-ekf6mja9	40	1	Overall	overall	RB
cord-006702-ekf6mja9	40	2	,	,	,
cord-006702-ekf6mja9	40	3	64	64	CD
cord-006702-ekf6mja9	40	4	%	%	NN
cord-006702-ekf6mja9	40	5	of	of	IN
cord-006702-ekf6mja9	40	6	pts	pt	NNS
cord-006702-ekf6mja9	40	7	were	be	VBD
cord-006702-ekf6mja9	40	8	alive	alive	JJ
cord-006702-ekf6mja9	40	9	at	at	IN
cord-006702-ekf6mja9	40	10	1	1	CD
cord-006702-ekf6mja9	40	11	yr	yr	NN
cord-006702-ekf6mja9	40	12	.	.	.
cord-006702-ekf6mja9	41	1	Five	five	CD
cord-006702-ekf6mja9	41	2	pts	pt	NNS
cord-006702-ekf6mja9	41	3	underwent	undergo	VBD
cord-006702-ekf6mja9	41	4	neonatal	neonatal	JJ
cord-006702-ekf6mja9	41	5	dialysis	dialysis	NN
cord-006702-ekf6mja9	41	6	with	with	IN
cord-006702-ekf6mja9	41	7	80	80	CD
cord-006702-ekf6mja9	41	8	%	%	NN
cord-006702-ekf6mja9	41	9	1	1	CD
cord-006702-ekf6mja9	41	10	yr	yr	NN
cord-006702-ekf6mja9	41	11	survival	survival	NN
cord-006702-ekf6mja9	41	12	.	.	.
cord-006702-ekf6mja9	42	1	For	for	IN
cord-006702-ekf6mja9	42	2	non	non	JJ
cord-006702-ekf6mja9	42	3	-	-	JJ
cord-006702-ekf6mja9	42	4	dialysis	dialysis	JJ
cord-006702-ekf6mja9	42	5	pts	pt	NNS
cord-006702-ekf6mja9	42	6	estimated	estimate	VBN
cord-006702-ekf6mja9	42	7	GFR	GFR	NNP
cord-006702-ekf6mja9	42	8	at	at	IN
cord-006702-ekf6mja9	42	9	1	1	CD
cord-006702-ekf6mja9	42	10	yr	yr	NN
cord-006702-ekf6mja9	42	11	was	be	VBD
cord-006702-ekf6mja9	42	12	not	not	RB
cord-006702-ekf6mja9	42	13	significantly	significantly	RB
cord-006702-ekf6mja9	42	14	different	different	JJ
cord-006702-ekf6mja9	42	15	between	between	IN
cord-006702-ekf6mja9	42	16	Stage	stage	NN
cord-006702-ekf6mja9	42	17	I	I	NNP
cord-006702-ekf6mja9	42	18	and	and	CC
cord-006702-ekf6mja9	42	19	II	II	NNP
cord-006702-ekf6mja9	42	20	.	.	.
cord-006702-ekf6mja9	43	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	43	2	:	:	:
cord-006702-ekf6mja9	44	1	Prenatal	prenatal	JJ
cord-006702-ekf6mja9	44	2	LUTO	LUTO	NNP
cord-006702-ekf6mja9	44	3	staging	staging	NN
cord-006702-ekf6mja9	44	4	is	be	VBZ
cord-006702-ekf6mja9	44	5	clinically	clinically	RB
cord-006702-ekf6mja9	44	6	useful	useful	JJ
cord-006702-ekf6mja9	44	7	as	as	IN
cord-006702-ekf6mja9	44	8	it	-PRON-	PRP
cord-006702-ekf6mja9	44	9	is	be	VBZ
cord-006702-ekf6mja9	44	10	strongly	strongly	RB
cord-006702-ekf6mja9	44	11	associated	associate	VBN
cord-006702-ekf6mja9	44	12	with	with	IN
cord-006702-ekf6mja9	44	13	both	both	DT
cord-006702-ekf6mja9	44	14	neonatal	neonatal	JJ
cord-006702-ekf6mja9	44	15	survival	survival	NN
cord-006702-ekf6mja9	44	16	and	and	CC
cord-006702-ekf6mja9	44	17	the	the	DT
cord-006702-ekf6mja9	44	18	need	need	NN
cord-006702-ekf6mja9	44	19	for	for	IN
cord-006702-ekf6mja9	44	20	neonatal	neonatal	JJ
cord-006702-ekf6mja9	44	21	dialysis	dialysis	NN
cord-006702-ekf6mja9	44	22	.	.	.
cord-006702-ekf6mja9	45	1	In	in	IN
cord-006702-ekf6mja9	45	2	addition	addition	NN
cord-006702-ekf6mja9	45	3	,	,	,
cord-006702-ekf6mja9	45	4	LUTO	LUTO	NNP
cord-006702-ekf6mja9	45	5	pts	pts	CC
cord-006702-ekf6mja9	45	6	who	who	WP
cord-006702-ekf6mja9	45	7	survive	survive	VBP
cord-006702-ekf6mja9	45	8	the	the	DT
cord-006702-ekf6mja9	45	9	neonatal	neonatal	JJ
cord-006702-ekf6mja9	45	10	period	period	NN
cord-006702-ekf6mja9	45	11	,	,	,
cord-006702-ekf6mja9	45	12	regardless	regardless	RB
cord-006702-ekf6mja9	45	13	of	of	IN
cord-006702-ekf6mja9	45	14	the	the	DT
cord-006702-ekf6mja9	45	15	need	need	NN
cord-006702-ekf6mja9	45	16	for	for	IN
cord-006702-ekf6mja9	45	17	dialysis	dialysis	NN
cord-006702-ekf6mja9	45	18	,	,	,
cord-006702-ekf6mja9	45	19	are	be	VBP
cord-006702-ekf6mja9	45	20	likely	likely	JJ
cord-006702-ekf6mja9	45	21	to	to	TO
cord-006702-ekf6mja9	45	22	be	be	VB
cord-006702-ekf6mja9	45	23	alive	alive	JJ
cord-006702-ekf6mja9	45	24	at	at	IN
cord-006702-ekf6mja9	45	25	1	1	CD
cord-006702-ekf6mja9	45	26	yr	yr	NN
cord-006702-ekf6mja9	45	27	of	of	IN
cord-006702-ekf6mja9	45	28	age	age	NN
cord-006702-ekf6mja9	45	29	.	.	.
cord-006702-ekf6mja9	46	1	S5	S5	NNP
cord-006702-ekf6mja9	46	2	-Blood	-Blood	NNP
cord-006702-ekf6mja9	46	3	pressure	pressure	NN
cord-006702-ekf6mja9	46	4	:	:	:
cord-006702-ekf6mja9	47	1	High	high	JJ
cord-006702-ekf6mja9	47	2	to	to	IN
cord-006702-ekf6mja9	47	3	low	low	JJ
cord-006702-ekf6mja9	47	4	FP	FP	NNP
cord-006702-ekf6mja9	47	5	-	-	HYPH
cord-006702-ekf6mja9	47	6	S05	S05	NNP
cord-006702-ekf6mja9	47	7	-	-	HYPH
cord-006702-ekf6mja9	47	8	1	1	CD
cord-006702-ekf6mja9	47	9	ABPM	ABPM	NNP
cord-006702-ekf6mja9	47	10	in	in	IN
cord-006702-ekf6mja9	47	11	children	child	NNS
cord-006702-ekf6mja9	47	12	and	and	CC
cord-006702-ekf6mja9	47	13	adolescents	adolescent	NNS
cord-006702-ekf6mja9	47	14	with	with	IN
cord-006702-ekf6mja9	47	15	renovascular	renovascular	JJ
cord-006702-ekf6mja9	47	16	hypertension	hypertension	NN
cord-006702-ekf6mja9	47	17	B.	B.	NNP
cord-006702-ekf6mja9	47	18	Leite	Leite	NNP
cord-006702-ekf6mja9	47	19	(	(	-LRB-
cord-006702-ekf6mja9	47	20	1	1	CD
cord-006702-ekf6mja9	47	21	)	)	-RRB-
cord-006702-ekf6mja9	47	22	,	,	,
cord-006702-ekf6mja9	47	23	G.	G.	NNP
cord-006702-ekf6mja9	47	24	Batista	Batista	NNP
cord-006702-ekf6mja9	47	25	(	(	-LRB-
cord-006702-ekf6mja9	47	26	2	2	CD
cord-006702-ekf6mja9	47	27	)	)	-RRB-
cord-006702-ekf6mja9	47	28	,	,	,
cord-006702-ekf6mja9	47	29	L.	L.	NNP
cord-006702-ekf6mja9	47	30	Suzuki	Suzuki	NNP
cord-006702-ekf6mja9	47	31	(	(	-LRB-
cord-006702-ekf6mja9	47	32	1	1	CD
cord-006702-ekf6mja9	47	33	)	)	-RRB-
cord-006702-ekf6mja9	47	34	,	,	,
cord-006702-ekf6mja9	47	35	L.	L.	NNP
cord-006702-ekf6mja9	47	36	Drager	Drager	NNP
cord-006702-ekf6mja9	47	37	(	(	-LRB-
cord-006702-ekf6mja9	47	38	2	2	CD
cord-006702-ekf6mja9	47	39	)	)	-RRB-
cord-006702-ekf6mja9	47	40	,	,	,
cord-006702-ekf6mja9	47	41	E.	E.	NNP
cord-006702-ekf6mja9	47	42	Furusawa	Furusawa	NNP
cord-006702-ekf6mja9	47	43	(	(	-LRB-
cord-006702-ekf6mja9	47	44	1	1	CD
cord-006702-ekf6mja9	47	45	)	)	-RRB-
cord-006702-ekf6mja9	47	46	,	,	,
cord-006702-ekf6mja9	47	47	V.	V.	NNP
cord-006702-ekf6mja9	47	48	Koch	Koch	NNP
cord-006702-ekf6mja9	47	49	(	(	-LRB-
cord-006702-ekf6mja9	47	50	1	1	CD
cord-006702-ekf6mja9	47	51	)	)	-RRB-
cord-006702-ekf6mja9	47	52	,	,	,
cord-006702-ekf6mja9	47	53	A.	A.	NNP
cord-006702-ekf6mja9	47	54	Watanabe	Watanabe	NNP
cord-006702-ekf6mja9	47	55	(	(	-LRB-
cord-006702-ekf6mja9	47	56	1	1	CD
cord-006702-ekf6mja9	47	57	)	)	-RRB-
cord-006702-ekf6mja9	48	1	(	(	-LRB-
cord-006702-ekf6mja9	48	2	1	1	LS
cord-006702-ekf6mja9	48	3	)	)	-RRB-
cord-006702-ekf6mja9	48	4	Instituto	Instituto	NNP
cord-006702-ekf6mja9	48	5	da	da	NNP
cord-006702-ekf6mja9	48	6	Criança	Criança	NNP
cord-006702-ekf6mja9	49	1	-HC	-HC	.
cord-006702-ekf6mja9	50	1	-FMUSP	-fmusp	RB
cord-006702-ekf6mja9	50	2	,	,	,
cord-006702-ekf6mja9	50	3	Sao	Sao	NNP
cord-006702-ekf6mja9	50	4	Paulo	Paulo	NNP
cord-006702-ekf6mja9	50	5	,	,	,
cord-006702-ekf6mja9	50	6	Brazil	Brazil	NNP
cord-006702-ekf6mja9	50	7	;	;	:
cord-006702-ekf6mja9	51	1	(	(	-LRB-
cord-006702-ekf6mja9	51	2	2	2	LS
cord-006702-ekf6mja9	51	3	)	)	-RRB-
cord-006702-ekf6mja9	51	4	Hospital	hospital	NN
cord-006702-ekf6mja9	51	5	das	das	NNP
cord-006702-ekf6mja9	51	6	Clínicas	Clínicas	NNP
cord-006702-ekf6mja9	51	7	-FMUSP	-FMUSP	VBD
cord-006702-ekf6mja9	51	8	,	,	,
cord-006702-ekf6mja9	51	9	Sao	Sao	NNP
cord-006702-ekf6mja9	51	10	Paulo	Paulo	NNP
cord-006702-ekf6mja9	51	11	,	,	,
cord-006702-ekf6mja9	52	1	Brazil	Brazil	NNP
cord-006702-ekf6mja9	52	2	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	52	3	:	:	:
cord-006702-ekf6mja9	53	1	To	to	TO
cord-006702-ekf6mja9	53	2	describe	describe	VB
cord-006702-ekf6mja9	53	3	clinical	clinical	JJ
cord-006702-ekf6mja9	53	4	presentation	presentation	NN
cord-006702-ekf6mja9	53	5	and	and	CC
cord-006702-ekf6mja9	53	6	Ambulatory	Ambulatory	NNP
cord-006702-ekf6mja9	53	7	Blood	Blood	NNP
cord-006702-ekf6mja9	53	8	Pressure	Pressure	NNP
cord-006702-ekf6mja9	53	9	Monitoring	Monitoring	NNP
cord-006702-ekf6mja9	53	10	(	(	-LRB-
cord-006702-ekf6mja9	53	11	ABPM	ABPM	NNP
cord-006702-ekf6mja9	53	12	)	)	-RRB-
cord-006702-ekf6mja9	53	13	profile	profile	NN
cord-006702-ekf6mja9	53	14	in	in	IN
cord-006702-ekf6mja9	53	15	a	a	DT
cord-006702-ekf6mja9	53	16	pediatric	pediatric	JJ
cord-006702-ekf6mja9	53	17	cohort	cohort	NN
cord-006702-ekf6mja9	53	18	with	with	IN
cord-006702-ekf6mja9	53	19	renovascular	renovascular	JJ
cord-006702-ekf6mja9	53	20	hypertension	hypertension	NN
cord-006702-ekf6mja9	53	21	(	(	-LRB-
cord-006702-ekf6mja9	53	22	RVH	RVH	NNP
cord-006702-ekf6mja9	53	23	)	)	-RRB-
cord-006702-ekf6mja9	53	24	.	.	.
cord-006702-ekf6mja9	54	1	Methods	method	NNS
cord-006702-ekf6mja9	54	2	:	:	:
cord-006702-ekf6mja9	55	1	Retrospective	retrospective	JJ
cord-006702-ekf6mja9	55	2	descriptive	descriptive	JJ
cord-006702-ekf6mja9	55	3	study	study	NN
cord-006702-ekf6mja9	55	4	of	of	IN
cord-006702-ekf6mja9	55	5	a	a	DT
cord-006702-ekf6mja9	55	6	cohort	cohort	NN
cord-006702-ekf6mja9	55	7	of	of	IN
cord-006702-ekf6mja9	55	8	pediatric	pediatric	JJ
cord-006702-ekf6mja9	55	9	patients	patient	NNS
cord-006702-ekf6mja9	55	10	(	(	-LRB-
cord-006702-ekf6mja9	55	11	pts	pt	NNS
cord-006702-ekf6mja9	55	12	)	)	-RRB-
cord-006702-ekf6mja9	55	13	with	with	IN
cord-006702-ekf6mja9	55	14	RVH	rvh	NN
cord-006702-ekf6mja9	55	15	including	include	VBG
cord-006702-ekf6mja9	55	16	analysis	analysis	NN
cord-006702-ekf6mja9	55	17	of	of	IN
cord-006702-ekf6mja9	55	18	ABPM	ABPM	NNP
cord-006702-ekf6mja9	55	19	profile	profile	NN
cord-006702-ekf6mja9	55	20	.	.	.
cord-006702-ekf6mja9	56	1	Results	result	NNS
cord-006702-ekf6mja9	56	2	:	:	:
cord-006702-ekf6mja9	57	1	27	27	CD
cord-006702-ekf6mja9	57	2	pts	pt	NNS
cord-006702-ekf6mja9	57	3	with	with	IN
cord-006702-ekf6mja9	57	4	RVH	RVH	NNP
cord-006702-ekf6mja9	57	5	are	be	VBP
cord-006702-ekf6mja9	57	6	described	describe	VBN
cord-006702-ekf6mja9	57	7	.	.	.
cord-006702-ekf6mja9	58	1	The	the	DT
cord-006702-ekf6mja9	58	2	initial	initial	JJ
cord-006702-ekf6mja9	58	3	clinical	clinical	JJ
cord-006702-ekf6mja9	58	4	presentation	presentation	NN
cord-006702-ekf6mja9	58	5	was	be	VBD
cord-006702-ekf6mja9	58	6	hypertensive	hypertensive	JJ
cord-006702-ekf6mja9	58	7	encephalopathy	encephalopathy	NN
cord-006702-ekf6mja9	58	8	in	in	IN
cord-006702-ekf6mja9	58	9	6/27	6/27	CD
cord-006702-ekf6mja9	58	10	;	;	:
cord-006702-ekf6mja9	58	11	congestive	congestive	JJ
cord-006702-ekf6mja9	58	12	heart	heart	NN
cord-006702-ekf6mja9	58	13	failure	failure	NN
cord-006702-ekf6mja9	58	14	6/27	6/27	CD
cord-006702-ekf6mja9	58	15	;	;	:
cord-006702-ekf6mja9	58	16	abdominal	abdominal	JJ
cord-006702-ekf6mja9	58	17	pain	pain	NN
cord-006702-ekf6mja9	58	18	2/27	2/27	CD
cord-006702-ekf6mja9	58	19	;	;	:
cord-006702-ekf6mja9	58	20	irritability	irritability	NN
cord-006702-ekf6mja9	58	21	1/27	1/27	CD
cord-006702-ekf6mja9	58	22	;	;	:
cord-006702-ekf6mja9	58	23	epistaxis	epistaxis	NN
cord-006702-ekf6mja9	58	24	1/27	1/27	CD
cord-006702-ekf6mja9	58	25	and	and	CC
cord-006702-ekf6mja9	58	26	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	58	27	in	in	IN
cord-006702-ekf6mja9	58	28	11/27	11/27	CD
cord-006702-ekf6mja9	58	29	pts	pt	NNS
cord-006702-ekf6mja9	58	30	.	.	.
cord-006702-ekf6mja9	59	1	Median	median	JJ
cord-006702-ekf6mja9	59	2	age	age	NN
cord-006702-ekf6mja9	59	3	was	be	VBD
cord-006702-ekf6mja9	59	4	4	4	CD
cord-006702-ekf6mja9	59	5	years	year	NNS
cord-006702-ekf6mja9	59	6	.	.	.
cord-006702-ekf6mja9	60	1	All	all	DT
cord-006702-ekf6mja9	60	2	pts	pt	NNS
cord-006702-ekf6mja9	60	3	had	have	VBD
cord-006702-ekf6mja9	60	4	systemic	systemic	JJ
cord-006702-ekf6mja9	60	5	arterial	arterial	JJ
cord-006702-ekf6mja9	60	6	hypertension	hypertension	NN
cord-006702-ekf6mja9	60	7	stage	stage	NN
cord-006702-ekf6mja9	60	8	2	2	CD
cord-006702-ekf6mja9	60	9	.	.	.
cord-006702-ekf6mja9	61	1	Fibromuscular	Fibromuscular	NNP
cord-006702-ekf6mja9	61	2	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	61	3	was	be	VBD
cord-006702-ekf6mja9	61	4	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	61	5	in	in	IN
cord-006702-ekf6mja9	61	6	8/27	8/27	CD
cord-006702-ekf6mja9	61	7	pts	pt	NNS
cord-006702-ekf6mja9	61	8	,	,	,
cord-006702-ekf6mja9	61	9	Takayasu	Takayasu	NNP
cord-006702-ekf6mja9	61	10	arteritis	arteritis	NN
cord-006702-ekf6mja9	61	11	in	in	IN
cord-006702-ekf6mja9	61	12	8/27	8/27	CD
cord-006702-ekf6mja9	61	13	,	,	,
cord-006702-ekf6mja9	61	14	Williams	Williams	NNP
cord-006702-ekf6mja9	61	15	syndrome	syndrome	NN
cord-006702-ekf6mja9	61	16	in	in	IN
cord-006702-ekf6mja9	61	17	5/27	5/27	CD
cord-006702-ekf6mja9	61	18	,	,	,
cord-006702-ekf6mja9	61	19	neurofibromatosis	neurofibromatosis	NN
cord-006702-ekf6mja9	61	20	in	in	IN
cord-006702-ekf6mja9	61	21	4/27	4/27	CD
cord-006702-ekf6mja9	61	22	,	,	,
cord-006702-ekf6mja9	61	23	1	1	CD
cord-006702-ekf6mja9	61	24	pt	pt	NN
cord-006702-ekf6mja9	61	25	was	be	VBD
cord-006702-ekf6mja9	61	26	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	61	27	with	with	IN
cord-006702-ekf6mja9	61	28	renal	renal	JJ
cord-006702-ekf6mja9	61	29	artery	artery	NN
cord-006702-ekf6mja9	61	30	compression	compression	NN
cord-006702-ekf6mja9	61	31	by	by	IN
cord-006702-ekf6mja9	61	32	pheochromocytoma	pheochromocytoma	NN
cord-006702-ekf6mja9	61	33	.	.	.
cord-006702-ekf6mja9	62	1	The	the	DT
cord-006702-ekf6mja9	62	2	vascular	vascular	JJ
cord-006702-ekf6mja9	62	3	lesion	lesion	NN
cord-006702-ekf6mja9	62	4	presented	present	VBN
cord-006702-ekf6mja9	62	5	as	as	IN
cord-006702-ekf6mja9	62	6	mid	mid	JJ
cord-006702-ekf6mja9	62	7	aortic	aortic	JJ
cord-006702-ekf6mja9	62	8	syndrome	syndrome	NN
cord-006702-ekf6mja9	62	9	with	with	IN
cord-006702-ekf6mja9	62	10	bilateral	bilateral	JJ
cord-006702-ekf6mja9	62	11	renal	renal	JJ
cord-006702-ekf6mja9	62	12	artery	artery	NN
cord-006702-ekf6mja9	62	13	stenosis	stenosis	NN
cord-006702-ekf6mja9	62	14	(	(	-LRB-
cord-006702-ekf6mja9	62	15	RAS	RAS	NNP
cord-006702-ekf6mja9	62	16	)	)	-RRB-
cord-006702-ekf6mja9	62	17	in	in	IN
cord-006702-ekf6mja9	62	18	12/27	12/27	CD
cord-006702-ekf6mja9	62	19	pts	pt	NNS
cord-006702-ekf6mja9	62	20	,	,	,
cord-006702-ekf6mja9	62	21	unilateral	unilateral	JJ
cord-006702-ekf6mja9	62	22	RAS	RAS	NNP
cord-006702-ekf6mja9	62	23	in	in	IN
cord-006702-ekf6mja9	62	24	10/27	10/27	CD
cord-006702-ekf6mja9	62	25	and	and	CC
cord-006702-ekf6mja9	62	26	bilateral	bilateral	JJ
cord-006702-ekf6mja9	62	27	RAS	RAS	NNP
cord-006702-ekf6mja9	62	28	in	in	IN
cord-006702-ekf6mja9	62	29	5/27	5/27	CD
cord-006702-ekf6mja9	62	30	pts	pt	NNS
cord-006702-ekf6mja9	62	31	.	.	.
cord-006702-ekf6mja9	63	1	Besides	besides	IN
cord-006702-ekf6mja9	63	2	anti	anti	JJ
cord-006702-ekf6mja9	63	3	-	-	JJ
cord-006702-ekf6mja9	63	4	hypertensive	hypertensive	JJ
cord-006702-ekf6mja9	63	5	medication	medication	NN
cord-006702-ekf6mja9	63	6	,	,	,
cord-006702-ekf6mja9	63	7	angioplasty	angioplasty	NN
cord-006702-ekf6mja9	63	8	was	be	VBD
cord-006702-ekf6mja9	63	9	performed	perform	VBN
cord-006702-ekf6mja9	63	10	in	in	IN
cord-006702-ekf6mja9	63	11	12/27	12/27	CD
cord-006702-ekf6mja9	63	12	pts	pt	NNS
cord-006702-ekf6mja9	63	13	,	,	,
cord-006702-ekf6mja9	63	14	aortorenal	aortorenal	JJ
cord-006702-ekf6mja9	63	15	surgery	surgery	NN
cord-006702-ekf6mja9	63	16	in	in	IN
cord-006702-ekf6mja9	63	17	9/27	9/27	CD
cord-006702-ekf6mja9	63	18	,	,	,
cord-006702-ekf6mja9	63	19	auto	auto	NN
cord-006702-ekf6mja9	63	20	-	-	HYPH
cord-006702-ekf6mja9	63	21	transplantation	transplantation	NN
cord-006702-ekf6mja9	63	22	in	in	IN
cord-006702-ekf6mja9	63	23	1/27	1/27	CD
cord-006702-ekf6mja9	63	24	,	,	,
cord-006702-ekf6mja9	63	25	excision	excision	NN
cord-006702-ekf6mja9	63	26	of	of	IN
cord-006702-ekf6mja9	63	27	pheochromocytoma	pheochromocytoma	NN
cord-006702-ekf6mja9	63	28	in	in	IN
cord-006702-ekf6mja9	63	29	1	1	CD
cord-006702-ekf6mja9	63	30	pt	pt	NN
cord-006702-ekf6mja9	63	31	;	;	:
cord-006702-ekf6mja9	63	32	4/27	4/27	CD
cord-006702-ekf6mja9	63	33	pts	pt	NNS
cord-006702-ekf6mja9	63	34	were	be	VBD
cord-006702-ekf6mja9	63	35	managed	manage	VBN
cord-006702-ekf6mja9	63	36	exclusively	exclusively	RB
cord-006702-ekf6mja9	63	37	with	with	IN
cord-006702-ekf6mja9	63	38	anti	anti	JJ
cord-006702-ekf6mja9	63	39	-	-	JJ
cord-006702-ekf6mja9	63	40	hypertensive	hypertensive	JJ
cord-006702-ekf6mja9	63	41	medication	medication	NN
cord-006702-ekf6mja9	63	42	.	.	.
cord-006702-ekf6mja9	64	1	Left	leave	VBN
cord-006702-ekf6mja9	64	2	ventricular	ventricular	JJ
cord-006702-ekf6mja9	64	3	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	64	4	was	be	VBD
cord-006702-ekf6mja9	64	5	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	64	6	in	in	IN
cord-006702-ekf6mja9	64	7	21/27	21/27	CD
cord-006702-ekf6mja9	64	8	children	child	NNS
cord-006702-ekf6mja9	64	9	.	.	.
cord-006702-ekf6mja9	65	1	29	29	CD
cord-006702-ekf6mja9	65	2	ABPM	ABPM	NNP
cord-006702-ekf6mja9	65	3	studies	study	NNS
cord-006702-ekf6mja9	65	4	were	be	VBD
cord-006702-ekf6mja9	65	5	performed	perform	VBN
cord-006702-ekf6mja9	65	6	in	in	IN
cord-006702-ekf6mja9	65	7	16	16	CD
cord-006702-ekf6mja9	65	8	pts	pt	NNS
cord-006702-ekf6mja9	65	9	at	at	IN
cord-006702-ekf6mja9	65	10	different	different	JJ
cord-006702-ekf6mja9	65	11	treatment	treatment	NN
cord-006702-ekf6mja9	65	12	phases	phase	NNS
cord-006702-ekf6mja9	65	13	;	;	:
cord-006702-ekf6mja9	65	14	24	24	CD
cord-006702-ekf6mja9	65	15	ABPM	ABPM	NNP
cord-006702-ekf6mja9	65	16	recordings	recording	NNS
cord-006702-ekf6mja9	65	17	were	be	VBD
cord-006702-ekf6mja9	65	18	analyzed	analyze	VBN
cord-006702-ekf6mja9	66	1	(	(	-LRB-
cord-006702-ekf6mja9	66	2	5	5	CD
cord-006702-ekf6mja9	66	3	were	be	VBD
cord-006702-ekf6mja9	66	4	excluded	exclude	VBN
cord-006702-ekf6mja9	66	5	by	by	IN
cord-006702-ekf6mja9	66	6	failure	failure	NN
cord-006702-ekf6mja9	66	7	of	of	IN
cord-006702-ekf6mja9	66	8	the	the	DT
cord-006702-ekf6mja9	66	9	measures	measure	NNS
cord-006702-ekf6mja9	66	10	)	)	-RRB-
cord-006702-ekf6mja9	66	11	.	.	.
cord-006702-ekf6mja9	67	1	After	after	IN
cord-006702-ekf6mja9	67	2	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	67	3	management	management	NN
cord-006702-ekf6mja9	67	4	,	,	,
cord-006702-ekf6mja9	67	5	only	only	RB
cord-006702-ekf6mja9	67	6	1/16	1/16	CD
cord-006702-ekf6mja9	67	7	pt	pt	NN
cord-006702-ekf6mja9	67	8	achieved	achieve	VBD
cord-006702-ekf6mja9	67	9	BP	BP	NNP
cord-006702-ekf6mja9	67	10	control	control	NN
cord-006702-ekf6mja9	67	11	by	by	IN
cord-006702-ekf6mja9	67	12	ABPM	ABPM	NNP
cord-006702-ekf6mja9	67	13	standards	standard	NNS
cord-006702-ekf6mja9	67	14	:	:	:
cord-006702-ekf6mja9	67	15	systolic	systolic	JJ
cord-006702-ekf6mja9	67	16	and	and	CC
cord-006702-ekf6mja9	67	17	diastolic	diastolic	JJ
cord-006702-ekf6mja9	67	18	(	(	-LRB-
cord-006702-ekf6mja9	67	19	S	s	NN
cord-006702-ekf6mja9	67	20	/	/	SYM
cord-006702-ekf6mja9	67	21	D	D	NNP
cord-006702-ekf6mja9	67	22	)	)	-RRB-
cord-006702-ekf6mja9	67	23	BP	BP	NNP
cord-006702-ekf6mja9	67	24	means	mean	VBZ
cord-006702-ekf6mja9	68	1	<	<	XX
cord-006702-ekf6mja9	68	2	95th	95th	NNP
cord-006702-ekf6mja9	68	3	percentile	percentile	NNP
cord-006702-ekf6mja9	68	4	and	and	CC
cord-006702-ekf6mja9	68	5	BP	BP	NNP
cord-006702-ekf6mja9	68	6	load	load	NN
cord-006702-ekf6mja9	68	7	<	<	XX
cord-006702-ekf6mja9	68	8	25	25	CD
cord-006702-ekf6mja9	68	9	%	%	NN
cord-006702-ekf6mja9	68	10	,	,	,
cord-006702-ekf6mja9	68	11	with	with	IN
cord-006702-ekf6mja9	68	12	S	S	NNP
cord-006702-ekf6mja9	68	13	/	/	SYM
cord-006702-ekf6mja9	68	14	Dnocturnal	Dnocturnal	NNP
cord-006702-ekf6mja9	68	15	BP	BP	NNP
cord-006702-ekf6mja9	68	16	dipping	dipping	NN
cord-006702-ekf6mja9	68	17	of	of	IN
cord-006702-ekf6mja9	68	18	8.7	8.7	CD
cord-006702-ekf6mja9	68	19	%	%	NN
cord-006702-ekf6mja9	68	20	and	and	CC
cord-006702-ekf6mja9	68	21	14.2	14.2	CD
cord-006702-ekf6mja9	68	22	%	%	NN
cord-006702-ekf6mja9	68	23	respectively	respectively	RB
cord-006702-ekf6mja9	68	24	.	.	.
cord-006702-ekf6mja9	69	1	The	the	DT
cord-006702-ekf6mja9	69	2	remaining	remain	VBG
cord-006702-ekf6mja9	69	3	15	15	CD
cord-006702-ekf6mja9	69	4	pts	pt	NNS
cord-006702-ekf6mja9	69	5	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	69	6	severe	severe	JJ
cord-006702-ekf6mja9	69	7	ambulatory	ambulatory	JJ
cord-006702-ekf6mja9	69	8	hypertension	hypertension	NN
cord-006702-ekf6mja9	69	9	,	,	,
cord-006702-ekf6mja9	69	10	with	with	IN
cord-006702-ekf6mja9	69	11	SBP/	SBP/	NNP
cord-006702-ekf6mja9	69	12	DBP	DBP	NNP
cord-006702-ekf6mja9	69	13	means	mean	VBZ
cord-006702-ekf6mja9	69	14	values	value	NNS
cord-006702-ekf6mja9	69	15	â'â	â'â	VBP
cord-006702-ekf6mja9	69	16	'	'	``
cord-006702-ekf6mja9	69	17	>	>	SYM
cord-006702-ekf6mja9	69	18	95th	95th	NN
cord-006702-ekf6mja9	69	19	percentile	percentile	NN
cord-006702-ekf6mja9	69	20	and	and	CC
cord-006702-ekf6mja9	69	21	loads	load	NNS
cord-006702-ekf6mja9	69	22	>	>	XX
cord-006702-ekf6mja9	69	23	50	50	CD
cord-006702-ekf6mja9	69	24	%	%	NN
cord-006702-ekf6mja9	69	25	.	.	.
cord-006702-ekf6mja9	70	1	S	S	NNP
cord-006702-ekf6mja9	70	2	/	/	SYM
cord-006702-ekf6mja9	70	3	D	D	NNP
cord-006702-ekf6mja9	70	4	nocturnal	nocturnal	JJ
cord-006702-ekf6mja9	70	5	BP	BP	NNP
cord-006702-ekf6mja9	70	6	dipping	dipping	NN
cord-006702-ekf6mja9	70	7	was	be	VBD
cord-006702-ekf6mja9	70	8	present	present	JJ
cord-006702-ekf6mja9	70	9	in	in	IN
cord-006702-ekf6mja9	70	10	5/24	5/24	CD
cord-006702-ekf6mja9	70	11	(	(	-LRB-
cord-006702-ekf6mja9	70	12	range	range	NN
cord-006702-ekf6mja9	70	13	10	10	CD
cord-006702-ekf6mja9	70	14	%	%	NN
cord-006702-ekf6mja9	70	15	-18.3	-18.3	CD
cord-006702-ekf6mja9	70	16	%	%	NN
cord-006702-ekf6mja9	70	17	)	)	-RRB-
cord-006702-ekf6mja9	70	18	and	and	CC
cord-006702-ekf6mja9	70	19	19/24	19/24	CD
cord-006702-ekf6mja9	71	1	(	(	-LRB-
cord-006702-ekf6mja9	71	2	range	range	VB
cord-006702-ekf6mja9	71	3	12.1	12.1	CD
cord-006702-ekf6mja9	71	4	%	%	NN
cord-006702-ekf6mja9	71	5	-26.6	-26.6	CD
cord-006702-ekf6mja9	71	6	%	%	NN
cord-006702-ekf6mja9	71	7	)	)	-RRB-
cord-006702-ekf6mja9	71	8	recordings	recording	NNS
cord-006702-ekf6mja9	71	9	respectively	respectively	RB
cord-006702-ekf6mja9	71	10	.	.	.
cord-006702-ekf6mja9	72	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	72	2	:	:	:
cord-006702-ekf6mja9	73	1	RVH	RVH	NNP
cord-006702-ekf6mja9	73	2	in	in	IN
cord-006702-ekf6mja9	73	3	children	child	NNS
cord-006702-ekf6mja9	73	4	presents	present	VBZ
cord-006702-ekf6mja9	73	5	with	with	IN
cord-006702-ekf6mja9	73	6	severe	severe	JJ
cord-006702-ekf6mja9	73	7	hypertension	hypertension	NN
cord-006702-ekf6mja9	73	8	and	and	CC
cord-006702-ekf6mja9	73	9	high	high	JJ
cord-006702-ekf6mja9	73	10	morbidity	morbidity	NN
cord-006702-ekf6mja9	73	11	.	.	.
cord-006702-ekf6mja9	74	1	ABPM	ABPM	NNP
cord-006702-ekf6mja9	74	2	is	be	VBZ
cord-006702-ekf6mja9	74	3	fundamental	fundamental	JJ
cord-006702-ekf6mja9	74	4	for	for	IN
cord-006702-ekf6mja9	74	5	BP	BP	NNP
cord-006702-ekf6mja9	74	6	control	control	NN
cord-006702-ekf6mja9	74	7	evaluation	evaluation	NN
cord-006702-ekf6mja9	74	8	.	.	.
cord-006702-ekf6mja9	75	1	FP	FP	NNP
cord-006702-ekf6mja9	75	2	-	-	HYPH
cord-006702-ekf6mja9	75	3	S05	S05	NNP
cord-006702-ekf6mja9	75	4	-	-	HYPH
cord-006702-ekf6mja9	75	5	2	2	CD
cord-006702-ekf6mja9	75	6	ESCORT	ESCORT	NNP
cord-006702-ekf6mja9	75	7	trial	trial	NN
cord-006702-ekf6mja9	75	8	-Effects	-effect	NNS
cord-006702-ekf6mja9	75	9	of	of	IN
cord-006702-ekf6mja9	75	10	strict	strict	JJ
cord-006702-ekf6mja9	75	11	control	control	NN
cord-006702-ekf6mja9	75	12	of	of	IN
cord-006702-ekf6mja9	75	13	blood	blood	NN
cord-006702-ekf6mja9	75	14	pressure	pressure	NN
cord-006702-ekf6mja9	75	15	in	in	IN
cord-006702-ekf6mja9	75	16	pediatric	pediatric	JJ
cord-006702-ekf6mja9	75	17	renal	renal	JJ
cord-006702-ekf6mja9	75	18	transplant	transplant	NN
cord-006702-ekf6mja9	75	19	recipients	recipient	NNS
cord-006702-ekf6mja9	75	20	-Final	-Final	NFP
cord-006702-ekf6mja9	75	21	results	result	NNS
cord-006702-ekf6mja9	75	22	from	from	IN
cord-006702-ekf6mja9	75	23	a	a	DT
cord-006702-ekf6mja9	75	24	randomized	randomized	JJ
cord-006702-ekf6mja9	75	25	controlled	control	VBN
cord-006702-ekf6mja9	75	26	trial	trial	NN
cord-006702-ekf6mja9	75	27	T.	T.	NNP
cord-006702-ekf6mja9	75	28	Seeman	Seeman	NNP
cord-006702-ekf6mja9	75	29	,	,	,
cord-006702-ekf6mja9	75	30	J.	J.	NNP
cord-006702-ekf6mja9	75	31	Dusek	Dusek	NNP
cord-006702-ekf6mja9	75	32	,	,	,
cord-006702-ekf6mja9	75	33	N.	N.	NNP
cord-006702-ekf6mja9	75	34	Simankova	Simankova	NNP
cord-006702-ekf6mja9	75	35	,	,	,
cord-006702-ekf6mja9	75	36	K.	K.	NNP
cord-006702-ekf6mja9	75	37	Vondrak	Vondrak	NNP
cord-006702-ekf6mja9	75	38	,	,	,
cord-006702-ekf6mja9	75	39	J.	J.	NNP
cord-006702-ekf6mja9	75	40	Zieg	Zieg	NNP
cord-006702-ekf6mja9	75	41	University	University	NNP
cord-006702-ekf6mja9	75	42	Hospital	Hospital	NNP
cord-006702-ekf6mja9	75	43	Motol	Motol	NNP
cord-006702-ekf6mja9	75	44	,	,	,
cord-006702-ekf6mja9	75	45	Charles	Charles	NNP
cord-006702-ekf6mja9	75	46	University	University	NNP
cord-006702-ekf6mja9	75	47	Prague	Prague	NNP
cord-006702-ekf6mja9	75	48	,	,	,
cord-006702-ekf6mja9	75	49	2nd	2nd	JJ
cord-006702-ekf6mja9	75	50	Faculty	Faculty	NNP
cord-006702-ekf6mja9	75	51	of	of	IN
cord-006702-ekf6mja9	75	52	Medicine	Medicine	NNP
cord-006702-ekf6mja9	75	53	,	,	,
cord-006702-ekf6mja9	75	54	Prague	Prague	NNP
cord-006702-ekf6mja9	75	55	5	5	CD
cord-006702-ekf6mja9	75	56	,	,	,
cord-006702-ekf6mja9	75	57	Czech	Czech	NNP
cord-006702-ekf6mja9	75	58	Republic	Republic	NNP
cord-006702-ekf6mja9	75	59	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	75	60	:	:	:
cord-006702-ekf6mja9	75	61	The	the	DT
cord-006702-ekf6mja9	75	62	aim	aim	NN
cord-006702-ekf6mja9	75	63	of	of	IN
cord-006702-ekf6mja9	75	64	this	this	DT
cord-006702-ekf6mja9	75	65	3	3	CD
cord-006702-ekf6mja9	75	66	year	year	NN
cord-006702-ekf6mja9	75	67	randomized	randomize	VBN
cord-006702-ekf6mja9	75	68	controlled	control	VBN
cord-006702-ekf6mja9	75	69	trial	trial	NN
cord-006702-ekf6mja9	75	70	was	be	VBD
cord-006702-ekf6mja9	75	71	to	to	TO
cord-006702-ekf6mja9	75	72	investigate	investigate	VB
cord-006702-ekf6mja9	75	73	whether	whether	IN
cord-006702-ekf6mja9	75	74	strict	strict	JJ
cord-006702-ekf6mja9	75	75	BP	BP	NNP
cord-006702-ekf6mja9	75	76	control	control	NN
cord-006702-ekf6mja9	75	77	can	can	MD
cord-006702-ekf6mja9	75	78	protect	protect	VB
cord-006702-ekf6mja9	75	79	kidney	kidney	NN
cord-006702-ekf6mja9	75	80	graft	graft	NN
cord-006702-ekf6mja9	75	81	.	.	.
cord-006702-ekf6mja9	76	1	We	-PRON-	PRP
cord-006702-ekf6mja9	76	2	present	present	VBP
cord-006702-ekf6mja9	76	3	the	the	DT
cord-006702-ekf6mja9	76	4	final	final	JJ
cord-006702-ekf6mja9	76	5	results	result	NNS
cord-006702-ekf6mja9	76	6	.	.	.
cord-006702-ekf6mja9	77	1	Methods	method	NNS
cord-006702-ekf6mja9	77	2	:	:	:
cord-006702-ekf6mja9	77	3	All	all	DT
cord-006702-ekf6mja9	77	4	23	23	CD
cord-006702-ekf6mja9	77	5	children	child	NNS
cord-006702-ekf6mja9	77	6	who	who	WP
cord-006702-ekf6mja9	77	7	fulfilled	fulfil	VBD
cord-006702-ekf6mja9	77	8	the	the	DT
cord-006702-ekf6mja9	77	9	inclusion	inclusion	NN
cord-006702-ekf6mja9	77	10	criteria	criterion	NNS
cord-006702-ekf6mja9	77	11	were	be	VBD
cord-006702-ekf6mja9	77	12	randomized	randomize	VBN
cord-006702-ekf6mja9	77	13	to	to	IN
cord-006702-ekf6mja9	77	14	standard	standard	JJ
cord-006702-ekf6mja9	77	15	BP	BP	NNP
cord-006702-ekf6mja9	77	16	group	group	NN
cord-006702-ekf6mja9	77	17	(	(	-LRB-
cord-006702-ekf6mja9	77	18	STAND	stand	VB
cord-006702-ekf6mja9	77	19	,	,	,
cord-006702-ekf6mja9	77	20	target	target	VB
cord-006702-ekf6mja9	77	21	24hr	24hr	JJ
cord-006702-ekf6mja9	77	22	MAP	MAP	NNP
cord-006702-ekf6mja9	77	23	50	50	CD
cord-006702-ekf6mja9	77	24	-	-	SYM
cord-006702-ekf6mja9	77	25	95	95	CD
cord-006702-ekf6mja9	78	1	th	th	XX
cord-006702-ekf6mja9	78	2	percentile	percentile	NN
cord-006702-ekf6mja9	78	3	,	,	,
cord-006702-ekf6mja9	78	4	n=11	n=11	FW
cord-006702-ekf6mja9	78	5	)	)	-RRB-
cord-006702-ekf6mja9	78	6	or	or	CC
cord-006702-ekf6mja9	78	7	intensified	intensify	VBD
cord-006702-ekf6mja9	78	8	BP	BP	NNP
cord-006702-ekf6mja9	78	9	group	group	NN
cord-006702-ekf6mja9	78	10	(	(	-LRB-
cord-006702-ekf6mja9	78	11	INTENS	INTENS	NNP
cord-006702-ekf6mja9	78	12	,	,	,
cord-006702-ekf6mja9	78	13	target	target	VB
cord-006702-ekf6mja9	78	14	24hr	24hr	JJ
cord-006702-ekf6mja9	78	15	MAP	map	NN
cord-006702-ekf6mja9	78	16	<	<	XX
cord-006702-ekf6mja9	78	17	50	50	CD
cord-006702-ekf6mja9	78	18	th	th	XX
cord-006702-ekf6mja9	78	19	percentile	percentile	NN
cord-006702-ekf6mja9	78	20	,	,	,
cord-006702-ekf6mja9	78	21	n=12	n=12	NNP
cord-006702-ekf6mja9	78	22	)	)	-RRB-
cord-006702-ekf6mja9	78	23	.	.	.
cord-006702-ekf6mja9	79	1	The	the	DT
cord-006702-ekf6mja9	79	2	primary	primary	JJ
cord-006702-ekf6mja9	79	3	endpoint	endpoint	NN
cord-006702-ekf6mja9	79	4	is	be	VBZ
cord-006702-ekf6mja9	79	5	the	the	DT
cord-006702-ekf6mja9	79	6	yearly	yearly	JJ
cord-006702-ekf6mja9	79	7	change	change	NN
cord-006702-ekf6mja9	79	8	in	in	IN
cord-006702-ekf6mja9	80	1	eGFR	eGFR	NNP
cord-006702-ekf6mja9	80	2	(	(	-LRB-
cord-006702-ekf6mja9	80	3	Schwartz	Schwartz	NNP
cord-006702-ekf6mja9	80	4	)	)	-RRB-
cord-006702-ekf6mja9	80	5	,	,	,
cord-006702-ekf6mja9	80	6	the	the	DT
cord-006702-ekf6mja9	80	7	secondary	secondary	JJ
cord-006702-ekf6mja9	80	8	BP	BP	NNP
cord-006702-ekf6mja9	80	9	,	,	,
cord-006702-ekf6mja9	80	10	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	80	11	and	and	CC
cord-006702-ekf6mja9	80	12	left	leave	VBD
cord-006702-ekf6mja9	80	13	ventricular	ventricular	JJ
cord-006702-ekf6mja9	80	14	mass	mass	NN
cord-006702-ekf6mja9	80	15	.	.	.
cord-006702-ekf6mja9	81	1	Results	result	NNS
cord-006702-ekf6mja9	81	2	:	:	:
cord-006702-ekf6mja9	82	1	A	a	DT
cord-006702-ekf6mja9	82	2	total	total	NN
cord-006702-ekf6mja9	82	3	of	of	IN
cord-006702-ekf6mja9	82	4	21	21	CD
cord-006702-ekf6mja9	82	5	children	child	NNS
cord-006702-ekf6mja9	82	6	completed	complete	VBD
cord-006702-ekf6mja9	82	7	the	the	DT
cord-006702-ekf6mja9	82	8	study	study	NN
cord-006702-ekf6mja9	82	9	(	(	-LRB-
cord-006702-ekf6mja9	82	10	2	2	CD
cord-006702-ekf6mja9	82	11	children	child	NNS
cord-006702-ekf6mja9	82	12	withdrawn	withdraw	VBN
cord-006702-ekf6mja9	82	13	due	due	IN
cord-006702-ekf6mja9	82	14	to	to	IN
cord-006702-ekf6mja9	82	15	steroid	steroid	NN
cord-006702-ekf6mja9	82	16	-	-	HYPH
cord-006702-ekf6mja9	82	17	resistant	resistant	JJ
cord-006702-ekf6mja9	82	18	or	or	CC
cord-006702-ekf6mja9	82	19	antibody	antibody	NN
cord-006702-ekf6mja9	82	20	mediated	mediate	VBD
cord-006702-ekf6mja9	82	21	acute	acute	JJ
cord-006702-ekf6mja9	82	22	rejection	rejection	NN
cord-006702-ekf6mja9	82	23	)	)	-RRB-
cord-006702-ekf6mja9	82	24	.	.	.
cord-006702-ekf6mja9	83	1	The	the	DT
cord-006702-ekf6mja9	83	2	results	result	NNS
cord-006702-ekf6mja9	83	3	on	on	IN
cord-006702-ekf6mja9	83	4	BP	BP	NNP
cord-006702-ekf6mja9	83	5	and	and	CC
cord-006702-ekf6mja9	83	6	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	83	7	are	be	VBP
cord-006702-ekf6mja9	83	8	given	give	VBN
cord-006702-ekf6mja9	83	9	in	in	IN
cord-006702-ekf6mja9	83	10	the	the	DT
cord-006702-ekf6mja9	83	11	Table	table	NN
cord-006702-ekf6mja9	83	12	,	,	,
cord-006702-ekf6mja9	83	13	the	the	DT
cord-006702-ekf6mja9	83	14	results	result	NNS
cord-006702-ekf6mja9	83	15	on	on	IN
cord-006702-ekf6mja9	83	16	eGFR	egfr	NN
cord-006702-ekf6mja9	83	17	will	will	MD
cord-006702-ekf6mja9	83	18	be	be	VB
cord-006702-ekf6mja9	83	19	presented	present	VBN
cord-006702-ekf6mja9	83	20	at	at	IN
cord-006702-ekf6mja9	83	21	the	the	DT
cord-006702-ekf6mja9	83	22	meeting	meeting	NN
cord-006702-ekf6mja9	83	23	.	.	.
cord-006702-ekf6mja9	84	1	&	&	CC
cord-006702-ekf6mja9	84	2	MAP	MAP	NNP
cord-006702-ekf6mja9	84	3	=	=	SYM
cord-006702-ekf6mja9	84	4	mean	mean	JJ
cord-006702-ekf6mja9	84	5	arterial	arterial	JJ
cord-006702-ekf6mja9	84	6	pressure	pressure	NN
cord-006702-ekf6mja9	84	7	,	,	,
cord-006702-ekf6mja9	84	8	MAP	map	NN
cord-006702-ekf6mja9	84	9	index	index	NN
cord-006702-ekf6mja9	84	10	=	=	SYM
cord-006702-ekf6mja9	84	11	mean	mean	JJ
cord-006702-ekf6mja9	84	12	patient	patient	NN
cord-006702-ekf6mja9	84	13	's	's	POS
cord-006702-ekf6mja9	84	14	MAP/95th	MAP/95th	NNP
cord-006702-ekf6mja9	84	15	perc	perc	NNS
cord-006702-ekf6mja9	84	16	.	.	.
cord-006702-ekf6mja9	85	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	85	2	:	:	:
cord-006702-ekf6mja9	86	1	This	this	DT
cord-006702-ekf6mja9	86	2	is	be	VBZ
cord-006702-ekf6mja9	86	3	the	the	DT
cord-006702-ekf6mja9	86	4	first	first	JJ
cord-006702-ekf6mja9	86	5	randomized	randomized	JJ
cord-006702-ekf6mja9	86	6	controlled	control	VBN
cord-006702-ekf6mja9	86	7	trial	trial	NN
cord-006702-ekf6mja9	86	8	on	on	IN
cord-006702-ekf6mja9	86	9	BP	BP	NNP
cord-006702-ekf6mja9	86	10	control	control	NN
cord-006702-ekf6mja9	86	11	and	and	CC
cord-006702-ekf6mja9	86	12	its	-PRON-	PRP$
cord-006702-ekf6mja9	86	13	effects	effect	NNS
cord-006702-ekf6mja9	86	14	on	on	IN
cord-006702-ekf6mja9	86	15	graft	graft	NN
cord-006702-ekf6mja9	86	16	function	function	NN
cord-006702-ekf6mja9	86	17	.	.	.
cord-006702-ekf6mja9	87	1	It	-PRON-	PRP
cord-006702-ekf6mja9	87	2	demonstrates	demonstrate	VBZ
cord-006702-ekf6mja9	87	3	that	that	IN
cord-006702-ekf6mja9	87	4	strict	strict	JJ
cord-006702-ekf6mja9	87	5	BP	BP	NNP
cord-006702-ekf6mja9	87	6	control	control	NN
cord-006702-ekf6mja9	87	7	is	be	VBZ
cord-006702-ekf6mja9	87	8	possible	possible	JJ
cord-006702-ekf6mja9	87	9	in	in	IN
cord-006702-ekf6mja9	87	10	the	the	DT
cord-006702-ekf6mja9	87	11	majority	majority	NN
cord-006702-ekf6mja9	87	12	of	of	IN
cord-006702-ekf6mja9	87	13	children	child	NNS
cord-006702-ekf6mja9	87	14	and	and	CC
cord-006702-ekf6mja9	87	15	that	that	IN
cord-006702-ekf6mja9	87	16	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	87	17	did	do	VBD
cord-006702-ekf6mja9	87	18	not	not	RB
cord-006702-ekf6mja9	87	19	change	change	VB
cord-006702-ekf6mja9	87	20	significantly	significantly	RB
cord-006702-ekf6mja9	87	21	.	.	.
cord-006702-ekf6mja9	88	1	The	the	DT
cord-006702-ekf6mja9	88	2	data	datum	NNS
cord-006702-ekf6mja9	88	3	on	on	IN
cord-006702-ekf6mja9	88	4	graft	graft	NN
cord-006702-ekf6mja9	88	5	function	function	NN
cord-006702-ekf6mja9	88	6	will	will	MD
cord-006702-ekf6mja9	88	7	show	show	VB
cord-006702-ekf6mja9	88	8	,	,	,
cord-006702-ekf6mja9	88	9	whether	whether	IN
cord-006702-ekf6mja9	88	10	strict	strict	JJ
cord-006702-ekf6mja9	88	11	BP	BP	NNP
cord-006702-ekf6mja9	88	12	control	control	NN
cord-006702-ekf6mja9	88	13	can	can	MD
cord-006702-ekf6mja9	88	14	retard	retard	VB
cord-006702-ekf6mja9	88	15	progression	progression	NN
cord-006702-ekf6mja9	88	16	of	of	IN
cord-006702-ekf6mja9	88	17	chronic	chronic	JJ
cord-006702-ekf6mja9	88	18	graft	graft	NN
cord-006702-ekf6mja9	88	19	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	88	20	.	.	.
cord-006702-ekf6mja9	89	1	Supported	support	VBN
cord-006702-ekf6mja9	89	2	by	by	IN
cord-006702-ekf6mja9	89	3	grant	grant	NN
cord-006702-ekf6mja9	89	4	AZV	AZV	NNP
cord-006702-ekf6mja9	89	5	of	of	IN
cord-006702-ekf6mja9	89	6	the	the	DT
cord-006702-ekf6mja9	89	7	Ministry	Ministry	NNP
cord-006702-ekf6mja9	89	8	of	of	IN
cord-006702-ekf6mja9	89	9	Health	Health	NNP
cord-006702-ekf6mja9	89	10	CZE	CZE	NNP
cord-006702-ekf6mja9	89	11	15	15	CD
cord-006702-ekf6mja9	89	12	-	-	HYPH
cord-006702-ekf6mja9	89	13	31586A	31586a	CD
cord-006702-ekf6mja9	89	14	..	..	.
cord-006702-ekf6mja9	90	1	First	first	JJ
cord-006702-ekf6mja9	90	2	evidence	evidence	NN
cord-006702-ekf6mja9	90	3	of	of	IN
cord-006702-ekf6mja9	90	4	progressive	progressive	JJ
cord-006702-ekf6mja9	90	5	left	left	JJ
cord-006702-ekf6mja9	90	6	ventricular	ventricular	JJ
cord-006702-ekf6mja9	90	7	mechanical	mechanical	JJ
cord-006702-ekf6mja9	90	8	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	90	9	during	during	IN
cord-006702-ekf6mja9	90	10	four	four	CD
cord-006702-ekf6mja9	90	11	year	year	NN
cord-006702-ekf6mja9	90	12	follow	follow	NN
cord-006702-ekf6mja9	90	13	-	-	HYPH
cord-006702-ekf6mja9	90	14	up	up	NN
cord-006702-ekf6mja9	90	15	in	in	IN
cord-006702-ekf6mja9	90	16	children	child	NNS
cord-006702-ekf6mja9	90	17	with	with	IN
cord-006702-ekf6mja9	90	18	CKD	CKD	NNP
cord-006702-ekf6mja9	90	19	:	:	:
cord-006702-ekf6mja9	90	20	the	the	DT
cord-006702-ekf6mja9	90	21	4C	4C	NNP
cord-006702-ekf6mja9	90	22	Study	Study	NNP
cord-006702-ekf6mja9	90	23	.	.	.
cord-006702-ekf6mja9	91	1	M.	M.	NNP
cord-006702-ekf6mja9	91	2	Chinali	Chinali	NNP
cord-006702-ekf6mja9	91	3	(	(	-LRB-
cord-006702-ekf6mja9	91	4	1	1	CD
cord-006702-ekf6mja9	91	5	)	)	-RRB-
cord-006702-ekf6mja9	91	6	,	,	.
cord-006702-ekf6mja9	92	1	M.C.	M.C.	NNP
cord-006702-ekf6mja9	92	2	Matteucci	Matteucci	NNP
cord-006702-ekf6mja9	92	3	(	(	-LRB-
cord-006702-ekf6mja9	92	4	1	1	CD
cord-006702-ekf6mja9	92	5	)	)	-RRB-
cord-006702-ekf6mja9	92	6	,	,	,
cord-006702-ekf6mja9	92	7	A.	A.	NNP
cord-006702-ekf6mja9	92	8	Franceschini	Franceschini	NNP
cord-006702-ekf6mja9	92	9	(	(	-LRB-
cord-006702-ekf6mja9	92	10	1	1	CD
cord-006702-ekf6mja9	92	11	)	)	-RRB-
cord-006702-ekf6mja9	92	12	,	,	,
cord-006702-ekf6mja9	92	13	C.	C.	NNP
cord-006702-ekf6mja9	92	14	Esposito	Esposito	NNP
cord-006702-ekf6mja9	92	15	(	(	-LRB-
cord-006702-ekf6mja9	92	16	1	1	CD
cord-006702-ekf6mja9	92	17	)	)	-RRB-
cord-006702-ekf6mja9	92	18	,	,	,
cord-006702-ekf6mja9	92	19	K.	K.	NNP
cord-006702-ekf6mja9	92	20	Azukaitis	Azukaitis	NNP
cord-006702-ekf6mja9	92	21	(	(	-LRB-
cord-006702-ekf6mja9	92	22	2	2	CD
cord-006702-ekf6mja9	92	23	)	)	-RRB-
cord-006702-ekf6mja9	92	24	,	,	,
cord-006702-ekf6mja9	92	25	A.	A.	NNP
cord-006702-ekf6mja9	92	26	Doyon	Doyon	NNP
cord-006702-ekf6mja9	92	27	(	(	-LRB-
cord-006702-ekf6mja9	92	28	2	2	CD
cord-006702-ekf6mja9	92	29	)	)	-RRB-
cord-006702-ekf6mja9	92	30	,	,	,
cord-006702-ekf6mja9	92	31	F.	F.	NNP
cord-006702-ekf6mja9	92	32	Drago	Drago	NNP
cord-006702-ekf6mja9	92	33	(	(	-LRB-
cord-006702-ekf6mja9	92	34	1	1	CD
cord-006702-ekf6mja9	92	35	)	)	-RRB-
cord-006702-ekf6mja9	92	36	,	,	,
cord-006702-ekf6mja9	92	37	F.	F.	NNP
cord-006702-ekf6mja9	92	38	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	92	39	(	(	-LRB-
cord-006702-ekf6mja9	92	40	2	2	CD
cord-006702-ekf6mja9	92	41	)	)	-RRB-
cord-006702-ekf6mja9	92	42	(	(	-LRB-
cord-006702-ekf6mja9	92	43	1	1	LS
cord-006702-ekf6mja9	92	44	)	)	-RRB-
cord-006702-ekf6mja9	92	45	Bambino	Bambino	NNP
cord-006702-ekf6mja9	92	46	Gesù	Gesù	NNP
cord-006702-ekf6mja9	92	47	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	92	48	Research	Research	NNP
cord-006702-ekf6mja9	92	49	Hospital	Hospital	NNP
cord-006702-ekf6mja9	92	50	,	,	,
cord-006702-ekf6mja9	92	51	Rome	Rome	NNP
cord-006702-ekf6mja9	92	52	,	,	,
cord-006702-ekf6mja9	92	53	Italy	Italy	NNP
cord-006702-ekf6mja9	92	54	;	;	:
cord-006702-ekf6mja9	92	55	(	(	-LRB-
cord-006702-ekf6mja9	92	56	2	2	LS
cord-006702-ekf6mja9	92	57	)	)	-RRB-
cord-006702-ekf6mja9	92	58	University	University	NNP
cord-006702-ekf6mja9	92	59	of	of	IN
cord-006702-ekf6mja9	92	60	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	92	61	,	,	,
cord-006702-ekf6mja9	92	62	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	92	63	,	,	,
cord-006702-ekf6mja9	92	64	Germany	Germany	NNP
cord-006702-ekf6mja9	92	65	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	92	66	:	:	:
cord-006702-ekf6mja9	93	1	We	-PRON-	PRP
cord-006702-ekf6mja9	93	2	have	have	VBP
cord-006702-ekf6mja9	93	3	previosuly	previosuly	VBN
cord-006702-ekf6mja9	93	4	shown	show	VBN
cord-006702-ekf6mja9	93	5	(	(	-LRB-
cord-006702-ekf6mja9	93	6	cJASN	cjasn	NN
cord-006702-ekf6mja9	93	7	2015	2015	CD
cord-006702-ekf6mja9	93	8	)	)	-RRB-
cord-006702-ekf6mja9	93	9	that	that	IN
cord-006702-ekf6mja9	93	10	despite	despite	IN
cord-006702-ekf6mja9	93	11	normal	normal	JJ
cord-006702-ekf6mja9	93	12	traditional	traditional	JJ
cord-006702-ekf6mja9	93	13	markers	marker	NNS
cord-006702-ekf6mja9	93	14	of	of	IN
cord-006702-ekf6mja9	93	15	cardiac	cardiac	JJ
cord-006702-ekf6mja9	93	16	funtion	funtion	NN
cord-006702-ekf6mja9	93	17	,	,	,
cord-006702-ekf6mja9	93	18	children	child	NNS
cord-006702-ekf6mja9	93	19	with	with	IN
cord-006702-ekf6mja9	93	20	CKD	CKD	NNP
cord-006702-ekf6mja9	93	21	exhibit	exhibit	NN
cord-006702-ekf6mja9	93	22	mechanical	mechanical	JJ
cord-006702-ekf6mja9	93	23	systolic	systolic	JJ
cord-006702-ekf6mja9	93	24	dysfuntion	dysfuntion	NN
cord-006702-ekf6mja9	93	25	characterized	characterize	VBN
cord-006702-ekf6mja9	93	26	by	by	IN
cord-006702-ekf6mja9	93	27	lower	low	JJR
cord-006702-ekf6mja9	93	28	radial	radial	JJ
cord-006702-ekf6mja9	93	29	strain	strain	NN
cord-006702-ekf6mja9	93	30	and	and	CC
cord-006702-ekf6mja9	93	31	transmural	transmural	JJ
cord-006702-ekf6mja9	93	32	systolic	systolic	JJ
cord-006702-ekf6mja9	93	33	gradient	gradient	NN
cord-006702-ekf6mja9	93	34	.	.	.
cord-006702-ekf6mja9	94	1	Objective	objective	NN
cord-006702-ekf6mja9	94	2	of	of	IN
cord-006702-ekf6mja9	94	3	our	-PRON-	PRP$
cord-006702-ekf6mja9	94	4	study	study	NN
cord-006702-ekf6mja9	94	5	wars	war	NNS
cord-006702-ekf6mja9	94	6	to	to	TO
cord-006702-ekf6mja9	94	7	analyze	analyze	VB
cord-006702-ekf6mja9	94	8	the	the	DT
cord-006702-ekf6mja9	94	9	evolution	evolution	NN
cord-006702-ekf6mja9	94	10	of	of	IN
cord-006702-ekf6mja9	94	11	cardiac	cardiac	JJ
cord-006702-ekf6mja9	94	12	mechcanics	mechcanic	NNS
cord-006702-ekf6mja9	94	13	through	through	IN
cord-006702-ekf6mja9	94	14	repeated	repeat	VBN
cord-006702-ekf6mja9	94	15	echocardiografic	echocardiografic	JJ
cord-006702-ekf6mja9	94	16	examination	examination	NN
cord-006702-ekf6mja9	94	17	in	in	IN
cord-006702-ekf6mja9	94	18	a	a	DT
cord-006702-ekf6mja9	94	19	large	large	JJ
cord-006702-ekf6mja9	94	20	sample	sample	NN
cord-006702-ekf6mja9	94	21	of	of	IN
cord-006702-ekf6mja9	94	22	children	child	NNS
cord-006702-ekf6mja9	94	23	with	with	IN
cord-006702-ekf6mja9	94	24	CKD	CKD	NNP
cord-006702-ekf6mja9	94	25	.	.	.
cord-006702-ekf6mja9	95	1	Methods	method	NNS
cord-006702-ekf6mja9	95	2	:	:	:
cord-006702-ekf6mja9	96	1	One	one	CD
cord-006702-ekf6mja9	96	2	hundred	hundred	CD
cord-006702-ekf6mja9	96	3	patients	patient	NNS
cord-006702-ekf6mja9	96	4	from	from	IN
cord-006702-ekf6mja9	96	5	the	the	DT
cord-006702-ekf6mja9	96	6	4C	4c	CD
cord-006702-ekf6mja9	96	7	study	study	NN
cord-006702-ekf6mja9	96	8	with	with	IN
cord-006702-ekf6mja9	96	9	repeated	repeat	VBN
cord-006702-ekf6mja9	96	10	echocardiographic	echocardiographic	JJ
cord-006702-ekf6mja9	96	11	examinations	examination	NNS
cord-006702-ekf6mja9	96	12	troughout	troughout	IN
cord-006702-ekf6mja9	96	13	four	four	CD
cord-006702-ekf6mja9	96	14	years	year	NNS
cord-006702-ekf6mja9	96	15	of	of	IN
cord-006702-ekf6mja9	96	16	follow	follow	NN
cord-006702-ekf6mja9	96	17	-	-	HYPH
cord-006702-ekf6mja9	96	18	up	up	NN
cord-006702-ekf6mja9	97	1	were	be	VBD
cord-006702-ekf6mja9	97	2	included	include	VBN
cord-006702-ekf6mja9	97	3	in	in	IN
cord-006702-ekf6mja9	97	4	the	the	DT
cord-006702-ekf6mja9	97	5	study	study	NN
cord-006702-ekf6mja9	97	6	.	.	.
cord-006702-ekf6mja9	98	1	Left	leave	VBN
cord-006702-ekf6mja9	98	2	ventricular	ventricular	JJ
cord-006702-ekf6mja9	99	1	(	(	-LRB-
cord-006702-ekf6mja9	99	2	LV	LV	NNP
cord-006702-ekf6mja9	99	3	)	)	-RRB-
cord-006702-ekf6mja9	99	4	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	99	5	was	be	VBD
cord-006702-ekf6mja9	99	6	defined	define	VBN
cord-006702-ekf6mja9	99	7	using	use	VBG
cord-006702-ekf6mja9	99	8	the	the	DT
cord-006702-ekf6mja9	99	9	simplified	simplified	JJ
cord-006702-ekf6mja9	99	10	approach	approach	NN
cord-006702-ekf6mja9	99	11	recently	recently	RB
cord-006702-ekf6mja9	99	12	described	describe	VBN
cord-006702-ekf6mja9	99	13	by	by	IN
cord-006702-ekf6mja9	99	14	our	-PRON-	PRP$
cord-006702-ekf6mja9	99	15	group	group	NN
cord-006702-ekf6mja9	99	16	(	(	-LRB-
cord-006702-ekf6mja9	99	17	J	J	NNP
cord-006702-ekf6mja9	99	18	Peds	Peds	NNP
cord-006702-ekf6mja9	99	19	2016	2016	CD
cord-006702-ekf6mja9	99	20	)	)	-RRB-
cord-006702-ekf6mja9	99	21	.	.	.
cord-006702-ekf6mja9	100	1	Advanced	advanced	JJ
cord-006702-ekf6mja9	100	2	parameters	parameter	NNS
cord-006702-ekf6mja9	100	3	of	of	IN
cord-006702-ekf6mja9	100	4	cardiac	cardiac	JJ
cord-006702-ekf6mja9	100	5	funtion	funtion	NN
cord-006702-ekf6mja9	100	6	included	include	VBD
cord-006702-ekf6mja9	100	7	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	100	8	epicardial	epicardial	NN
cord-006702-ekf6mja9	100	9	and	and	CC
cord-006702-ekf6mja9	100	10	endocardial	endocardial	JJ
cord-006702-ekf6mja9	100	11	strain	strain	NN
cord-006702-ekf6mja9	100	12	,	,	,
cord-006702-ekf6mja9	100	13	circumferential	circumferential	JJ
cord-006702-ekf6mja9	100	14	epicardial	epicardial	NN
cord-006702-ekf6mja9	100	15	and	and	CC
cord-006702-ekf6mja9	100	16	endocardial	endocardial	JJ
cord-006702-ekf6mja9	100	17	strain	strain	VB
cord-006702-ekf6mja9	100	18	as	as	RB
cord-006702-ekf6mja9	100	19	well	well	RB
cord-006702-ekf6mja9	100	20	as	as	IN
cord-006702-ekf6mja9	100	21	radial	radial	JJ
cord-006702-ekf6mja9	100	22	strain	strain	NN
cord-006702-ekf6mja9	100	23	.	.	.
cord-006702-ekf6mja9	101	1	Results	result	NNS
cord-006702-ekf6mja9	101	2	:	:	:
cord-006702-ekf6mja9	102	1	During	during	IN
cord-006702-ekf6mja9	102	2	four	four	CD
cord-006702-ekf6mja9	102	3	years	year	NNS
cord-006702-ekf6mja9	102	4	of	of	IN
cord-006702-ekf6mja9	102	5	follow	follow	NN
cord-006702-ekf6mja9	102	6	-	-	HYPH
cord-006702-ekf6mja9	102	7	up	up	NN
cord-006702-ekf6mja9	102	8	no	no	DT
cord-006702-ekf6mja9	102	9	significant	significant	JJ
cord-006702-ekf6mja9	102	10	changes	change	NNS
cord-006702-ekf6mja9	102	11	in	in	IN
cord-006702-ekf6mja9	102	12	ejection	ejection	NN
cord-006702-ekf6mja9	102	13	fraction	fraction	NN
cord-006702-ekf6mja9	102	14	could	could	MD
cord-006702-ekf6mja9	102	15	be	be	VB
cord-006702-ekf6mja9	102	16	observed	observe	VBN
cord-006702-ekf6mja9	102	17	in	in	IN
cord-006702-ekf6mja9	102	18	the	the	DT
cord-006702-ekf6mja9	102	19	whole	whole	JJ
cord-006702-ekf6mja9	102	20	population	population	NN
cord-006702-ekf6mja9	102	21	.	.	.
cord-006702-ekf6mja9	103	1	In	in	IN
cord-006702-ekf6mja9	103	2	contrast	contrast	NN
cord-006702-ekf6mja9	103	3	changes	change	NNS
cord-006702-ekf6mja9	103	4	in	in	IN
cord-006702-ekf6mja9	103	5	cardiac	cardiac	JJ
cord-006702-ekf6mja9	103	6	mechcanics	mechcanic	NNS
cord-006702-ekf6mja9	103	7	parameters	parameter	NNS
cord-006702-ekf6mja9	103	8	could	could	MD
cord-006702-ekf6mja9	103	9	be	be	VB
cord-006702-ekf6mja9	103	10	observed	observe	VBN
cord-006702-ekf6mja9	103	11	during	during	IN
cord-006702-ekf6mja9	103	12	the	the	DT
cord-006702-ekf6mja9	103	13	study	study	NN
cord-006702-ekf6mja9	103	14	period	period	NN
cord-006702-ekf6mja9	103	15	in	in	IN
cord-006702-ekf6mja9	103	16	both	both	DT
cord-006702-ekf6mja9	103	17	endocardial	endocardial	JJ
cord-006702-ekf6mja9	103	18	circumferential	circumferential	JJ
cord-006702-ekf6mja9	103	19	strain	strain	NN
cord-006702-ekf6mja9	103	20	(	(	-LRB-
cord-006702-ekf6mja9	103	21	mean	mean	VB
cord-006702-ekf6mja9	103	22	difference	difference	NN
cord-006702-ekf6mja9	103	23	6.05+/-2.02	6.05+/-2.02	CD
cord-006702-ekf6mja9	103	24	%	%	NN
cord-006702-ekf6mja9	103	25	)	)	-RRB-
cord-006702-ekf6mja9	103	26	and	and	CC
cord-006702-ekf6mja9	103	27	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	103	28	strain	strain	NN
cord-006702-ekf6mja9	103	29	(	(	-LRB-
cord-006702-ekf6mja9	104	1	mean	mean	VB
cord-006702-ekf6mja9	104	2	difference	difference	NN
cord-006702-ekf6mja9	104	3	4.15+/-1.76	4.15+/-1.76	CD
cord-006702-ekf6mja9	104	4	%	%	NN
cord-006702-ekf6mja9	104	5	;	;	:
cord-006702-ekf6mja9	104	6	p	p	NN
cord-006702-ekf6mja9	104	7	for	for	IN
cord-006702-ekf6mja9	104	8	both	both	CC
cord-006702-ekf6mja9	104	9	<	<	XX
cord-006702-ekf6mja9	104	10	0.05	0.05	CD
cord-006702-ekf6mja9	104	11	)	)	-RRB-
cord-006702-ekf6mja9	104	12	.	.	.
cord-006702-ekf6mja9	105	1	No	no	DT
cord-006702-ekf6mja9	105	2	change	change	NN
cord-006702-ekf6mja9	105	3	in	in	IN
cord-006702-ekf6mja9	105	4	parameters	parameter	NNS
cord-006702-ekf6mja9	105	5	of	of	IN
cord-006702-ekf6mja9	105	6	cardiac	cardiac	JJ
cord-006702-ekf6mja9	105	7	mechanics	mechanic	NNS
cord-006702-ekf6mja9	105	8	could	could	MD
cord-006702-ekf6mja9	105	9	be	be	VB
cord-006702-ekf6mja9	105	10	observed	observe	VBN
cord-006702-ekf6mja9	105	11	in	in	IN
cord-006702-ekf6mja9	105	12	children	child	NNS
cord-006702-ekf6mja9	105	13	with	with	IN
cord-006702-ekf6mja9	105	14	normal	normal	JJ
cord-006702-ekf6mja9	105	15	LV	LV	NNP
cord-006702-ekf6mja9	105	16	mass	mass	NN
cord-006702-ekf6mja9	105	17	at	at	IN
cord-006702-ekf6mja9	105	18	baseline	baseline	NN
cord-006702-ekf6mja9	105	19	(	(	-LRB-
cord-006702-ekf6mja9	105	20	p	p	NN
cord-006702-ekf6mja9	105	21	=	=	SYM
cord-006702-ekf6mja9	105	22	NS	ns	NN
cord-006702-ekf6mja9	105	23	for	for	IN
cord-006702-ekf6mja9	105	24	all	all	DT
cord-006702-ekf6mja9	105	25	)	)	-RRB-
cord-006702-ekf6mja9	105	26	,	,	,
cord-006702-ekf6mja9	105	27	while	while	IN
cord-006702-ekf6mja9	105	28	a	a	DT
cord-006702-ekf6mja9	105	29	significant	significant	JJ
cord-006702-ekf6mja9	105	30	reduction	reduction	NN
cord-006702-ekf6mja9	105	31	of	of	IN
cord-006702-ekf6mja9	105	32	cardiac	cardiac	JJ
cord-006702-ekf6mja9	105	33	systolic	systolic	JJ
cord-006702-ekf6mja9	105	34	parameters	parameter	NNS
cord-006702-ekf6mja9	105	35	was	be	VBD
cord-006702-ekf6mja9	105	36	found	find	VBN
cord-006702-ekf6mja9	105	37	in	in	IN
cord-006702-ekf6mja9	105	38	children	child	NNS
cord-006702-ekf6mja9	105	39	with	with	IN
cord-006702-ekf6mja9	105	40	baseline	baseline	JJ
cord-006702-ekf6mja9	105	41	LV	LV	NNP
cord-006702-ekf6mja9	105	42	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	105	43	in	in	IN
cord-006702-ekf6mja9	105	44	both	both	DT
cord-006702-ekf6mja9	105	45	endocardial	endocardial	JJ
cord-006702-ekf6mja9	105	46	circumferential	circumferential	JJ
cord-006702-ekf6mja9	105	47	strain	strain	NN
cord-006702-ekf6mja9	105	48	(	(	-LRB-
cord-006702-ekf6mja9	106	1	mean	mean	VB
cord-006702-ekf6mja9	106	2	difference	difference	NN
cord-006702-ekf6mja9	106	3	9.12+/-4.14	9.12+/-4.14	CD
cord-006702-ekf6mja9	106	4	%	%	NN
cord-006702-ekf6mja9	106	5	)	)	-RRB-
cord-006702-ekf6mja9	106	6	and	and	CC
cord-006702-ekf6mja9	106	7	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	106	8	strain	strain	NN
cord-006702-ekf6mja9	106	9	(	(	-LRB-
cord-006702-ekf6mja9	106	10	mean	mean	VB
cord-006702-ekf6mja9	106	11	difference	difference	NN
cord-006702-ekf6mja9	106	12	7.55+/-2.43%p	7.55+/-2.43%p	NNP
cord-006702-ekf6mja9	106	13	for	for	IN
cord-006702-ekf6mja9	106	14	both	both	CC
cord-006702-ekf6mja9	106	15	<	<	XX
cord-006702-ekf6mja9	106	16	0.02	0.02	CD
cord-006702-ekf6mja9	106	17	)	)	-RRB-
cord-006702-ekf6mja9	106	18	.	.	.
cord-006702-ekf6mja9	107	1	In	in	IN
cord-006702-ekf6mja9	107	2	time	time	NN
cord-006702-ekf6mja9	107	3	varying	vary	VBG
cord-006702-ekf6mja9	107	4	covariate	covariate	NN
cord-006702-ekf6mja9	107	5	analysis	analysis	NN
cord-006702-ekf6mja9	107	6	,	,	,
cord-006702-ekf6mja9	107	7	main	main	JJ
cord-006702-ekf6mja9	107	8	determinants	determinant	NNS
cord-006702-ekf6mja9	107	9	of	of	IN
cord-006702-ekf6mja9	107	10	progressive	progressive	JJ
cord-006702-ekf6mja9	107	11	reduction	reduction	NN
cord-006702-ekf6mja9	107	12	in	in	IN
cord-006702-ekf6mja9	107	13	cardiac	cardiac	JJ
cord-006702-ekf6mja9	107	14	mechaincs	mechaincs	NNP
cord-006702-ekf6mja9	107	15	were	be	VBD
cord-006702-ekf6mja9	107	16	the	the	DT
cord-006702-ekf6mja9	107	17	presence	presence	NN
cord-006702-ekf6mja9	107	18	of	of	IN
cord-006702-ekf6mja9	107	19	LV	LV	NNP
cord-006702-ekf6mja9	107	20	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	107	21	and	and	CC
cord-006702-ekf6mja9	107	22	of	of	IN
cord-006702-ekf6mja9	107	23	LV	LV	NNP
cord-006702-ekf6mja9	107	24	concentric	concentric	JJ
cord-006702-ekf6mja9	107	25	geometry	geometry	NN
cord-006702-ekf6mja9	107	26	.	.	.
cord-006702-ekf6mja9	108	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	108	2	:	:	:
cord-006702-ekf6mja9	109	1	Despite	despite	IN
cord-006702-ekf6mja9	109	2	parameters	parameter	NNS
cord-006702-ekf6mja9	109	3	of	of	IN
cord-006702-ekf6mja9	109	4	traditional	traditional	JJ
cord-006702-ekf6mja9	109	5	caridiac	caridiac	NNS
cord-006702-ekf6mja9	109	6	function	function	NN
cord-006702-ekf6mja9	109	7	remain	remain	VBP
cord-006702-ekf6mja9	109	8	normal	normal	JJ
cord-006702-ekf6mja9	109	9	during	during	IN
cord-006702-ekf6mja9	109	10	the	the	DT
cord-006702-ekf6mja9	109	11	years	year	NNS
cord-006702-ekf6mja9	109	12	,	,	,
cord-006702-ekf6mja9	109	13	in	in	IN
cord-006702-ekf6mja9	109	14	the	the	DT
cord-006702-ekf6mja9	109	15	presence	presence	NN
cord-006702-ekf6mja9	109	16	of	of	IN
cord-006702-ekf6mja9	109	17	LV	LV	NNP
cord-006702-ekf6mja9	109	18	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	109	19	,	,	,
cord-006702-ekf6mja9	109	20	progressive	progressive	JJ
cord-006702-ekf6mja9	109	21	deterioration	deterioration	NN
cord-006702-ekf6mja9	109	22	of	of	IN
cord-006702-ekf6mja9	109	23	cardiac	cardiac	JJ
cord-006702-ekf6mja9	109	24	mechanics	mechanic	NNS
cord-006702-ekf6mja9	109	25	can	can	MD
cord-006702-ekf6mja9	109	26	be	be	VB
cord-006702-ekf6mja9	109	27	observed	observe	VBN
cord-006702-ekf6mja9	109	28	in	in	IN
cord-006702-ekf6mja9	109	29	children	child	NNS
cord-006702-ekf6mja9	109	30	with	with	IN
cord-006702-ekf6mja9	109	31	chronic	chronic	JJ
cord-006702-ekf6mja9	109	32	CKD	CKD	NNP
cord-006702-ekf6mja9	109	33	.	.	.
cord-006702-ekf6mja9	110	1	Objectives	objective	NNS
cord-006702-ekf6mja9	110	2	:	:	:
cord-006702-ekf6mja9	110	3	To	to	TO
cord-006702-ekf6mja9	110	4	assess	assess	VB
cord-006702-ekf6mja9	110	5	the	the	DT
cord-006702-ekf6mja9	110	6	prevalence	prevalence	NN
cord-006702-ekf6mja9	110	7	of	of	IN
cord-006702-ekf6mja9	110	8	blood	blood	NN
cord-006702-ekf6mja9	110	9	pressure	pressure	NN
cord-006702-ekf6mja9	110	10	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	110	11	by	by	IN
cord-006702-ekf6mja9	110	12	ambulatory	ambulatory	JJ
cord-006702-ekf6mja9	110	13	blood	blood	NN
cord-006702-ekf6mja9	110	14	pressure	pressure	NN
cord-006702-ekf6mja9	110	15	monitoring	monitoring	NN
cord-006702-ekf6mja9	110	16	(	(	-LRB-
cord-006702-ekf6mja9	110	17	ABPM	ABPM	NNP
cord-006702-ekf6mja9	110	18	)	)	-RRB-
cord-006702-ekf6mja9	110	19	in	in	IN
cord-006702-ekf6mja9	110	20	a	a	DT
cord-006702-ekf6mja9	110	21	large	large	JJ
cord-006702-ekf6mja9	110	22	European	european	JJ
cord-006702-ekf6mja9	110	23	cohort	cohort	NN
cord-006702-ekf6mja9	110	24	of	of	IN
cord-006702-ekf6mja9	110	25	children	child	NNS
cord-006702-ekf6mja9	110	26	with	with	IN
cord-006702-ekf6mja9	110	27	autosomal	autosomal	JJ
cord-006702-ekf6mja9	110	28	dominant	dominant	JJ
cord-006702-ekf6mja9	110	29	polycystic	polycystic	JJ
cord-006702-ekf6mja9	110	30	kidney	kidney	NN
cord-006702-ekf6mja9	110	31	diseases	disease	NNS
cord-006702-ekf6mja9	110	32	(	(	-LRB-
cord-006702-ekf6mja9	110	33	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	110	34	)	)	-RRB-
cord-006702-ekf6mja9	110	35	.	.	.
cord-006702-ekf6mja9	111	1	Methods	method	NNS
cord-006702-ekf6mja9	111	2	:	:	:
cord-006702-ekf6mja9	111	3	Multicentric	Multicentric	NNP
cord-006702-ekf6mja9	111	4	retrospective	retrospective	JJ
cord-006702-ekf6mja9	111	5	study	study	NN
cord-006702-ekf6mja9	111	6	.	.	.
cord-006702-ekf6mja9	112	1	Inclusion	inclusion	NN
cord-006702-ekf6mja9	112	2	criteria	criterion	NNS
cord-006702-ekf6mja9	112	3	:	:	:
cord-006702-ekf6mja9	112	4	age	age	NN
cord-006702-ekf6mja9	112	5	<	<	XX
cord-006702-ekf6mja9	112	6	18	18	CD
cord-006702-ekf6mja9	112	7	years	year	NNS
cord-006702-ekf6mja9	112	8	,	,	,
cord-006702-ekf6mja9	112	9	ABPM	ABPM	NNP
cord-006702-ekf6mja9	112	10	recording	recording	NN
cord-006702-ekf6mja9	112	11	,	,	,
cord-006702-ekf6mja9	112	12	basic	basic	JJ
cord-006702-ekf6mja9	112	13	anthropometric	anthropometric	JJ
cord-006702-ekf6mja9	112	14	and	and	CC
cord-006702-ekf6mja9	112	15	laboratory	laboratory	NN
cord-006702-ekf6mja9	112	16	data	datum	NNS
cord-006702-ekf6mja9	112	17	,	,	,
cord-006702-ekf6mja9	112	18	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	112	19	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	112	20	based	base	VBN
cord-006702-ekf6mja9	112	21	on	on	IN
cord-006702-ekf6mja9	112	22	family	family	NN
cord-006702-ekf6mja9	112	23	history	history	NN
cord-006702-ekf6mja9	112	24	and	and	CC
cord-006702-ekf6mja9	112	25	renal	renal	JJ
cord-006702-ekf6mja9	112	26	cysts	cyst	NNS
cord-006702-ekf6mja9	112	27	or	or	CC
cord-006702-ekf6mja9	112	28	on	on	IN
cord-006702-ekf6mja9	112	29	genetic	genetic	JJ
cord-006702-ekf6mja9	112	30	test	test	NN
cord-006702-ekf6mja9	112	31	.	.	.
cord-006702-ekf6mja9	113	1	Results	result	NNS
cord-006702-ekf6mja9	113	2	:	:	:
cord-006702-ekf6mja9	113	3	310	310	CD
cord-006702-ekf6mja9	113	4	patients	patient	NNS
cord-006702-ekf6mja9	113	5	were	be	VBD
cord-006702-ekf6mja9	113	6	enrolled	enrol	VBN
cord-006702-ekf6mja9	113	7	in	in	IN
cord-006702-ekf6mja9	113	8	22	22	CD
cord-006702-ekf6mja9	113	9	European	european	JJ
cord-006702-ekf6mja9	113	10	centers	center	NNS
cord-006702-ekf6mja9	113	11	(	(	-LRB-
cord-006702-ekf6mja9	113	12	M	m	NN
cord-006702-ekf6mja9	113	13	:	:	:
cord-006702-ekf6mja9	113	14	F	F	NNP
cord-006702-ekf6mja9	113	15	ratio	ratio	NN
cord-006702-ekf6mja9	113	16	162:148	162:148	CD
cord-006702-ekf6mja9	113	17	;	;	:
cord-006702-ekf6mja9	113	18	mean	mean	VB
cord-006702-ekf6mja9	113	19	age	age	NN
cord-006702-ekf6mja9	113	20	11.5	11.5	CD
cord-006702-ekf6mja9	113	21	±	±	CD
cord-006702-ekf6mja9	113	22	4.2	4.2	CD
cord-006702-ekf6mja9	113	23	years	year	NNS
cord-006702-ekf6mja9	113	24	)	)	-RRB-
cord-006702-ekf6mja9	113	25	.	.	.
cord-006702-ekf6mja9	114	1	When	when	WRB
cord-006702-ekf6mja9	114	2	present	present	JJ
cord-006702-ekf6mja9	114	3	,	,	,
cord-006702-ekf6mja9	114	4	paternal	paternal	JJ
cord-006702-ekf6mja9	114	5	and	and	CC
cord-006702-ekf6mja9	114	6	maternal	maternal	JJ
cord-006702-ekf6mja9	114	7	inheritance	inheritance	NN
cord-006702-ekf6mja9	114	8	were	be	VBD
cord-006702-ekf6mja9	114	9	equally	equally	RB
cord-006702-ekf6mja9	114	10	distributed	distribute	VBN
cord-006702-ekf6mja9	114	11	(	(	-LRB-
cord-006702-ekf6mja9	114	12	43	43	CD
cord-006702-ekf6mja9	114	13	%	%	NN
cord-006702-ekf6mja9	114	14	-44	-44	NN
cord-006702-ekf6mja9	114	15	%	%	NN
cord-006702-ekf6mja9	114	16	)	)	-RRB-
cord-006702-ekf6mja9	114	17	.	.	.
cord-006702-ekf6mja9	115	1	A	a	DT
cord-006702-ekf6mja9	115	2	minority	minority	NN
cord-006702-ekf6mja9	115	3	of	of	IN
cord-006702-ekf6mja9	115	4	patients	patient	NNS
cord-006702-ekf6mja9	115	5	underwent	undergo	VBD
cord-006702-ekf6mja9	115	6	genetic	genetic	JJ
cord-006702-ekf6mja9	115	7	testing	testing	NN
cord-006702-ekf6mja9	115	8	:	:	:
cord-006702-ekf6mja9	116	1	PKD1	PKD1	NNP
cord-006702-ekf6mja9	116	2	and	and	CC
cord-006702-ekf6mja9	116	3	PKD2	PKD2	NNP
cord-006702-ekf6mja9	116	4	mutations	mutation	NNS
cord-006702-ekf6mja9	116	5	were	be	VBD
cord-006702-ekf6mja9	116	6	reported	report	VBN
cord-006702-ekf6mja9	116	7	in	in	IN
cord-006702-ekf6mja9	116	8	32	32	CD
cord-006702-ekf6mja9	116	9	%	%	NN
cord-006702-ekf6mja9	116	10	and	and	CC
cord-006702-ekf6mja9	116	11	0	0	CD
cord-006702-ekf6mja9	116	12	%	%	NN
cord-006702-ekf6mja9	116	13	of	of	IN
cord-006702-ekf6mja9	116	14	patients	patient	NNS
cord-006702-ekf6mja9	116	15	,	,	,
cord-006702-ekf6mja9	116	16	respectively	respectively	RB
cord-006702-ekf6mja9	116	17	.	.	.
cord-006702-ekf6mja9	117	1	Only	only	RB
cord-006702-ekf6mja9	117	2	7	7	CD
cord-006702-ekf6mja9	117	3	patients	patient	NNS
cord-006702-ekf6mja9	117	4	(	(	-LRB-
cord-006702-ekf6mja9	117	5	2.2	2.2	CD
cord-006702-ekf6mja9	117	6	%	%	NN
cord-006702-ekf6mja9	117	7	)	)	-RRB-
cord-006702-ekf6mja9	117	8	had	have	VBD
cord-006702-ekf6mja9	117	9	a	a	DT
cord-006702-ekf6mja9	117	10	eGFR	egfr	NN
cord-006702-ekf6mja9	117	11	<	<	XX
cord-006702-ekf6mja9	117	12	90	90	CD
cord-006702-ekf6mja9	117	13	ml	ml	NNS
cord-006702-ekf6mja9	117	14	/	/	SYM
cord-006702-ekf6mja9	117	15	min/1.73mq	min/1.73mq	XX
cord-006702-ekf6mja9	117	16	.	.	.
cord-006702-ekf6mja9	118	1	Overall	overall	RB
cord-006702-ekf6mja9	118	2	,	,	,
cord-006702-ekf6mja9	118	3	34	34	CD
cord-006702-ekf6mja9	118	4	%	%	NN
cord-006702-ekf6mja9	118	5	of	of	IN
cord-006702-ekf6mja9	118	6	patients	patient	NNS
cord-006702-ekf6mja9	118	7	had	have	VBD
cord-006702-ekf6mja9	118	8	24h	24h	NNS
cord-006702-ekf6mja9	118	9	mean	mean	VB
cord-006702-ekf6mja9	118	10	ABPM	ABPM	NNP
cord-006702-ekf6mja9	118	11	values	value	NNS
cord-006702-ekf6mja9	119	1	>	>	XX
cord-006702-ekf6mja9	120	1	95th	95th	JJ
cord-006702-ekf6mja9	120	2	percentile	percentile	NN
cord-006702-ekf6mja9	120	3	or	or	CC
cord-006702-ekf6mja9	120	4	were	be	VBD
cord-006702-ekf6mja9	120	5	treated	treat	VBN
cord-006702-ekf6mja9	120	6	with	with	IN
cord-006702-ekf6mja9	120	7	blood	blood	NN
cord-006702-ekf6mja9	120	8	pressure	pressure	NN
cord-006702-ekf6mja9	120	9	medications	medication	NNS
cord-006702-ekf6mja9	120	10	.	.	.
cord-006702-ekf6mja9	121	1	Pre	pre	JJ
cord-006702-ekf6mja9	121	2	-	-	JJ
cord-006702-ekf6mja9	121	3	hypertension	hypertension	NN
cord-006702-ekf6mja9	121	4	was	be	VBD
cord-006702-ekf6mja9	121	5	present	present	JJ
cord-006702-ekf6mja9	121	6	in	in	IN
cord-006702-ekf6mja9	121	7	10	10	CD
cord-006702-ekf6mja9	121	8	%	%	NN
cord-006702-ekf6mja9	121	9	of	of	IN
cord-006702-ekf6mja9	121	10	patients	patient	NNS
cord-006702-ekf6mja9	121	11	and	and	CC
cord-006702-ekf6mja9	121	12	borderline	borderline	JJ
cord-006702-ekf6mja9	121	13	hypertension	hypertension	NN
cord-006702-ekf6mja9	121	14	in	in	IN
cord-006702-ekf6mja9	121	15	26	26	CD
cord-006702-ekf6mja9	121	16	%	%	NN
cord-006702-ekf6mja9	121	17	of	of	IN
cord-006702-ekf6mja9	121	18	patients	patient	NNS
cord-006702-ekf6mja9	121	19	.	.	.
cord-006702-ekf6mja9	122	1	Daytime	daytime	JJ
cord-006702-ekf6mja9	122	2	heart	heart	NN
cord-006702-ekf6mja9	122	3	rate	rate	NN
cord-006702-ekf6mja9	122	4	was	be	VBD
cord-006702-ekf6mja9	122	5	significantly	significantly	RB
cord-006702-ekf6mja9	122	6	lower	low	JJR
cord-006702-ekf6mja9	122	7	in	in	IN
cord-006702-ekf6mja9	122	8	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	122	9	children	child	NNS
cord-006702-ekf6mja9	122	10	compared	compare	VBN
cord-006702-ekf6mja9	122	11	to	to	IN
cord-006702-ekf6mja9	122	12	healthy	healthy	JJ
cord-006702-ekf6mja9	122	13	controls	control	NNS
cord-006702-ekf6mja9	122	14	(	(	-LRB-
cord-006702-ekf6mja9	122	15	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	122	16	)	)	-RRB-
cord-006702-ekf6mja9	122	17	.	.	.
cord-006702-ekf6mja9	123	1	A	a	DT
cord-006702-ekf6mja9	123	2	significant	significant	JJ
cord-006702-ekf6mja9	123	3	proportion	proportion	NN
cord-006702-ekf6mja9	123	4	of	of	IN
cord-006702-ekf6mja9	123	5	patients	patient	NNS
cord-006702-ekf6mja9	123	6	had	have	VBD
cord-006702-ekf6mja9	123	7	elevated	elevate	VBN
cord-006702-ekf6mja9	123	8	nighttime	nighttime	JJ
cord-006702-ekf6mja9	123	9	blood	blood	NN
cord-006702-ekf6mja9	123	10	pressure	pressure	NN
cord-006702-ekf6mja9	123	11	values	value	NNS
cord-006702-ekf6mja9	123	12	:	:	:
cord-006702-ekf6mja9	123	13	35	35	CD
cord-006702-ekf6mja9	123	14	%	%	NN
cord-006702-ekf6mja9	123	15	were	be	VBD
cord-006702-ekf6mja9	123	16	non	non	JJ
cord-006702-ekf6mja9	123	17	-	-	NNS
cord-006702-ekf6mja9	123	18	dippers	dipper	NNS
cord-006702-ekf6mja9	123	19	and	and	CC
cord-006702-ekf6mja9	123	20	19	19	CD
cord-006702-ekf6mja9	123	21	%	%	NN
cord-006702-ekf6mja9	123	22	had	have	VBD
cord-006702-ekf6mja9	123	23	isolated	isolate	VBN
cord-006702-ekf6mja9	123	24	nocturnal	nocturnal	JJ
cord-006702-ekf6mja9	123	25	hypertension	hypertension	NN
cord-006702-ekf6mja9	123	26	.	.	.
cord-006702-ekf6mja9	124	1	As	as	IN
cord-006702-ekf6mja9	124	2	expected	expect	VBN
cord-006702-ekf6mja9	124	3	,	,	,
cord-006702-ekf6mja9	124	4	the	the	DT
cord-006702-ekf6mja9	124	5	proportion	proportion	NN
cord-006702-ekf6mja9	124	6	of	of	IN
cord-006702-ekf6mja9	124	7	patients	patient	NNS
cord-006702-ekf6mja9	124	8	with	with	IN
cord-006702-ekf6mja9	124	9	enlarged	enlarged	JJ
cord-006702-ekf6mja9	124	10	kidneys	kidney	NNS
cord-006702-ekf6mja9	124	11	increased	increase	VBD
cord-006702-ekf6mja9	124	12	with	with	IN
cord-006702-ekf6mja9	124	13	age	age	NN
cord-006702-ekf6mja9	124	14	;	;	:
cord-006702-ekf6mja9	124	15	conversely	conversely	RB
cord-006702-ekf6mja9	124	16	,	,	,
cord-006702-ekf6mja9	124	17	correlation	correlation	NN
cord-006702-ekf6mja9	124	18	between	between	IN
cord-006702-ekf6mja9	124	19	age	age	NN
cord-006702-ekf6mja9	124	20	and	and	CC
cord-006702-ekf6mja9	124	21	hypertension	hypertension	NN
cord-006702-ekf6mja9	124	22	was	be	VBD
cord-006702-ekf6mja9	124	23	weak	weak	JJ
cord-006702-ekf6mja9	124	24	.	.	.
cord-006702-ekf6mja9	125	1	Further	further	JJ
cord-006702-ekf6mja9	125	2	rhythm	rhythm	NN
cord-006702-ekf6mja9	125	3	analysis	analysis	NN
cord-006702-ekf6mja9	125	4	revealed	reveal	VBD
cord-006702-ekf6mja9	125	5	a	a	DT
cord-006702-ekf6mja9	125	6	very	very	RB
cord-006702-ekf6mja9	125	7	high	high	JJ
cord-006702-ekf6mja9	125	8	prevalence	prevalence	NN
cord-006702-ekf6mja9	125	9	of	of	IN
cord-006702-ekf6mja9	125	10	circadian	circadian	NN
cord-006702-ekf6mja9	125	11	and	and	CC
cord-006702-ekf6mja9	125	12	ultradian	ultradian	JJ
cord-006702-ekf6mja9	125	13	rhytms	rhytms	NN
cord-006702-ekf6mja9	125	14	in	in	IN
cord-006702-ekf6mja9	125	15	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	125	16	patients	patient	NNS
cord-006702-ekf6mja9	125	17	,	,	,
cord-006702-ekf6mja9	125	18	including	include	VBG
cord-006702-ekf6mja9	125	19	pre	pre	JJ
cord-006702-ekf6mja9	125	20	-	-	JJ
cord-006702-ekf6mja9	125	21	pubertal	pubertal	JJ
cord-006702-ekf6mja9	125	22	children	child	NNS
cord-006702-ekf6mja9	125	23	.	.	.
cord-006702-ekf6mja9	126	1	These	these	DT
cord-006702-ekf6mja9	126	2	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	126	3	exceeded	exceed	VBD
cord-006702-ekf6mja9	126	4	those	those	DT
cord-006702-ekf6mja9	126	5	reported	report	VBN
cord-006702-ekf6mja9	126	6	in	in	IN
cord-006702-ekf6mja9	126	7	children	child	NNS
cord-006702-ekf6mja9	126	8	with	with	IN
cord-006702-ekf6mja9	126	9	chronic	chronic	JJ
cord-006702-ekf6mja9	126	10	renal	renal	JJ
cord-006702-ekf6mja9	126	11	failure	failure	NN
cord-006702-ekf6mja9	126	12	.	.	.
cord-006702-ekf6mja9	127	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	127	2	:	:	:
cord-006702-ekf6mja9	128	1	Despite	despite	IN
cord-006702-ekf6mja9	128	2	potential	potential	JJ
cord-006702-ekf6mja9	128	3	recruitment	recruitment	NN
cord-006702-ekf6mja9	128	4	biases	bias	NNS
cord-006702-ekf6mja9	128	5	,	,	,
cord-006702-ekf6mja9	128	6	this	this	DT
cord-006702-ekf6mja9	128	7	study	study	NN
cord-006702-ekf6mja9	128	8	shows	show	VBZ
cord-006702-ekf6mja9	128	9	very	very	RB
cord-006702-ekf6mja9	128	10	high	high	JJ
cord-006702-ekf6mja9	128	11	prevalence	prevalence	NN
cord-006702-ekf6mja9	128	12	of	of	IN
cord-006702-ekf6mja9	128	13	blood	blood	NN
cord-006702-ekf6mja9	128	14	pressure	pressure	NN
cord-006702-ekf6mja9	128	15	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	128	16	in	in	IN
cord-006702-ekf6mja9	128	17	children	child	NNS
cord-006702-ekf6mja9	128	18	with	with	IN
cord-006702-ekf6mja9	128	19	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	128	20	,	,	,
cord-006702-ekf6mja9	128	21	suggesting	suggest	VBG
cord-006702-ekf6mja9	128	22	autonomic	autonomic	JJ
cord-006702-ekf6mja9	128	23	dysregulation	dysregulation	NN
cord-006702-ekf6mja9	128	24	and	and	CC
cord-006702-ekf6mja9	128	25	early	early	JJ
cord-006702-ekf6mja9	128	26	onset	onset	NN
cord-006702-ekf6mja9	128	27	of	of	IN
cord-006702-ekf6mja9	128	28	cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	128	29	damage	damage	NN
cord-006702-ekf6mja9	128	30	.	.	.
cord-006702-ekf6mja9	129	1	FP	FP	NNP
cord-006702-ekf6mja9	129	2	-	-	HYPH
cord-006702-ekf6mja9	129	3	S06	S06	NNP
cord-006702-ekf6mja9	129	4	-	-	HYPH
cord-006702-ekf6mja9	129	5	1	1	CD
cord-006702-ekf6mja9	129	6	Detection	Detection	NNP
cord-006702-ekf6mja9	129	7	of	of	IN
cord-006702-ekf6mja9	129	8	novel	novel	JJ
cord-006702-ekf6mja9	129	9	non	non	JJ
cord-006702-ekf6mja9	129	10	-	-	JJ
cord-006702-ekf6mja9	129	11	labelling	labelling	JJ
cord-006702-ekf6mja9	129	12	biomarkers	biomarker	NNS
cord-006702-ekf6mja9	129	13	of	of	IN
cord-006702-ekf6mja9	129	14	progressive	progressive	JJ
cord-006702-ekf6mja9	129	15	glomerulonephritis	glomerulonephritis	NN
cord-006702-ekf6mja9	129	16	using	use	VBG
cord-006702-ekf6mja9	129	17	fourier	fourier	NNP
cord-006702-ekf6mja9	129	18	transform	transform	VB
cord-006702-ekf6mja9	129	19	infrared	infrared	JJ
cord-006702-ekf6mja9	129	20	spectroscopy	spectroscopy	NN
cord-006702-ekf6mja9	129	21	M	M	NNP
cord-006702-ekf6mja9	129	22	-	-	HYPH
cord-006702-ekf6mja9	129	23	C.	C.	NNP
cord-006702-ekf6mja9	129	24	Yu	Yu	NNP
cord-006702-ekf6mja9	129	25	(	(	-LRB-
cord-006702-ekf6mja9	129	26	1	1	CD
cord-006702-ekf6mja9	129	27	)	)	-RRB-
cord-006702-ekf6mja9	129	28	,	,	,
cord-006702-ekf6mja9	129	29	R.	R.	NNP
cord-006702-ekf6mja9	129	30	Peter	Peter	NNP
cord-006702-ekf6mja9	129	31	(	(	-LRB-
cord-006702-ekf6mja9	129	32	2	2	CD
cord-006702-ekf6mja9	129	33	)	)	-RRB-
cord-006702-ekf6mja9	130	1	Objectives	objective	NNS
cord-006702-ekf6mja9	130	2	:	:	:
cord-006702-ekf6mja9	130	3	More	more	RBR
cord-006702-ekf6mja9	130	4	reliable	reliable	JJ
cord-006702-ekf6mja9	130	5	biological	biological	JJ
cord-006702-ekf6mja9	130	6	markers	marker	NNS
cord-006702-ekf6mja9	130	7	using	use	VBG
cord-006702-ekf6mja9	130	8	near	near	JJ
cord-006702-ekf6mja9	130	9	patient	patient	NN
cord-006702-ekf6mja9	130	10	technology	technology	NN
cord-006702-ekf6mja9	130	11	are	be	VBP
cord-006702-ekf6mja9	130	12	desirable	desirable	JJ
cord-006702-ekf6mja9	130	13	to	to	TO
cord-006702-ekf6mja9	130	14	improve	improve	VB
cord-006702-ekf6mja9	130	15	early	early	JJ
cord-006702-ekf6mja9	130	16	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	130	17	of	of	IN
cord-006702-ekf6mja9	130	18	patients	patient	NNS
cord-006702-ekf6mja9	130	19	at	at	IN
cord-006702-ekf6mja9	130	20	risk	risk	NN
cord-006702-ekf6mja9	130	21	of	of	IN
cord-006702-ekf6mja9	130	22	progressive	progressive	JJ
cord-006702-ekf6mja9	130	23	kidney	kidney	NN
cord-006702-ekf6mja9	130	24	disease	disease	NN
cord-006702-ekf6mja9	130	25	.	.	.
cord-006702-ekf6mja9	131	1	Over	over	IN
cord-006702-ekf6mja9	131	2	the	the	DT
cord-006702-ekf6mja9	131	3	past	past	JJ
cord-006702-ekf6mja9	131	4	two	two	CD
cord-006702-ekf6mja9	131	5	decades	decade	NNS
cord-006702-ekf6mja9	131	6	,	,	,
cord-006702-ekf6mja9	131	7	fourier	fourier	NNP
cord-006702-ekf6mja9	131	8	transform	transform	VB
cord-006702-ekf6mja9	131	9	infrared	infrared	JJ
cord-006702-ekf6mja9	131	10	spectroscopy	spectroscopy	NN
cord-006702-ekf6mja9	131	11	/	/	SYM
cord-006702-ekf6mja9	131	12	microscopy	microscopy	NN
cord-006702-ekf6mja9	131	13	has	have	VBZ
cord-006702-ekf6mja9	131	14	been	be	VBN
cord-006702-ekf6mja9	131	15	increasingly	increasingly	RB
cord-006702-ekf6mja9	131	16	applied	apply	VBN
cord-006702-ekf6mja9	131	17	to	to	IN
cord-006702-ekf6mja9	131	18	biomedical	biomedical	JJ
cord-006702-ekf6mja9	131	19	research	research	NN
cord-006702-ekf6mja9	131	20	such	such	JJ
cord-006702-ekf6mja9	131	21	as	as	IN
cord-006702-ekf6mja9	131	22	cancer	cancer	NN
cord-006702-ekf6mja9	131	23	.	.	.
cord-006702-ekf6mja9	132	1	However	however	RB
cord-006702-ekf6mja9	132	2	,	,	,
cord-006702-ekf6mja9	132	3	thus	thus	RB
cord-006702-ekf6mja9	132	4	far	far	RB
cord-006702-ekf6mja9	132	5	FTIR	FTIR	NNP
cord-006702-ekf6mja9	132	6	methods	method	NNS
cord-006702-ekf6mja9	132	7	have	have	VBP
cord-006702-ekf6mja9	132	8	not	not	RB
cord-006702-ekf6mja9	132	9	yet	yet	RB
cord-006702-ekf6mja9	132	10	been	be	VBN
cord-006702-ekf6mja9	132	11	applied	apply	VBN
cord-006702-ekf6mja9	132	12	to	to	IN
cord-006702-ekf6mja9	132	13	detection	detection	NN
cord-006702-ekf6mja9	132	14	of	of	IN
cord-006702-ekf6mja9	132	15	progressive	progressive	JJ
cord-006702-ekf6mja9	132	16	kidney	kidney	NN
cord-006702-ekf6mja9	132	17	diseases	disease	NNS
cord-006702-ekf6mja9	132	18	.	.	.
cord-006702-ekf6mja9	133	1	Therefore	therefore	RB
cord-006702-ekf6mja9	133	2	,	,	,
cord-006702-ekf6mja9	133	3	in	in	IN
cord-006702-ekf6mja9	133	4	the	the	DT
cord-006702-ekf6mja9	133	5	study	study	NN
cord-006702-ekf6mja9	133	6	,	,	,
cord-006702-ekf6mja9	133	7	this	this	DT
cord-006702-ekf6mja9	133	8	technology	technology	NN
cord-006702-ekf6mja9	133	9	was	be	VBD
cord-006702-ekf6mja9	133	10	employed	employ	VBN
cord-006702-ekf6mja9	133	11	to	to	TO
cord-006702-ekf6mja9	133	12	analyze	analyze	VB
cord-006702-ekf6mja9	133	13	urine	urine	NN
cord-006702-ekf6mja9	133	14	and	and	CC
cord-006702-ekf6mja9	133	15	plasma	plasma	NN
cord-006702-ekf6mja9	133	16	samples	sample	NNS
cord-006702-ekf6mja9	133	17	collected	collect	VBN
cord-006702-ekf6mja9	133	18	from	from	IN
cord-006702-ekf6mja9	133	19	rodent	rodent	NN
cord-006702-ekf6mja9	133	20	models	model	NNS
cord-006702-ekf6mja9	133	21	of	of	IN
cord-006702-ekf6mja9	133	22	progressive	progressive	JJ
cord-006702-ekf6mja9	133	23	glomerulonephritis	glomerulonephritis	NN
cord-006702-ekf6mja9	133	24	(	(	-LRB-
cord-006702-ekf6mja9	133	25	GN	GN	NNP
cord-006702-ekf6mja9	133	26	)	)	-RRB-
cord-006702-ekf6mja9	133	27	,	,	,
cord-006702-ekf6mja9	133	28	with	with	IN
cord-006702-ekf6mja9	133	29	the	the	DT
cord-006702-ekf6mja9	133	30	aim	aim	NN
cord-006702-ekf6mja9	133	31	of	of	IN
cord-006702-ekf6mja9	133	32	discovering	discover	VBG
cord-006702-ekf6mja9	133	33	more	more	RBR
cord-006702-ekf6mja9	133	34	sensitive	sensitive	JJ
cord-006702-ekf6mja9	133	35	biomarkers	biomarker	NNS
cord-006702-ekf6mja9	133	36	of	of	IN
cord-006702-ekf6mja9	133	37	renal	renal	JJ
cord-006702-ekf6mja9	133	38	injury	injury	NN
cord-006702-ekf6mja9	133	39	.	.	.
cord-006702-ekf6mja9	134	1	Methods	method	NNS
cord-006702-ekf6mja9	134	2	:	:	:
cord-006702-ekf6mja9	134	3	Experimental	experimental	JJ
cord-006702-ekf6mja9	134	4	GN	gn	NN
cord-006702-ekf6mja9	134	5	:	:	:
cord-006702-ekf6mja9	134	6	nephrotoxic	nephrotoxic	NNP
cord-006702-ekf6mja9	134	7	nephritis	nephritis	NN
cord-006702-ekf6mja9	134	8	(	(	-LRB-
cord-006702-ekf6mja9	134	9	NTN	NTN	NNP
cord-006702-ekf6mja9	134	10	)	)	-RRB-
cord-006702-ekf6mja9	134	11	was	be	VBD
cord-006702-ekf6mja9	134	12	induced	induce	VBN
cord-006702-ekf6mja9	134	13	in	in	IN
cord-006702-ekf6mja9	134	14	male	male	JJ
cord-006702-ekf6mja9	134	15	Wistar	Wistar	NNP
cord-006702-ekf6mja9	134	16	Kyoto	Kyoto	NNP
cord-006702-ekf6mja9	134	17	rats	rat	NNS
cord-006702-ekf6mja9	134	18	.	.	.
cord-006702-ekf6mja9	135	1	Urine	urine	NN
cord-006702-ekf6mja9	135	2	and	and	CC
cord-006702-ekf6mja9	135	3	plasma	plasma	NN
cord-006702-ekf6mja9	135	4	were	be	VBD
cord-006702-ekf6mja9	135	5	collected	collect	VBN
cord-006702-ekf6mja9	135	6	from	from	IN
cord-006702-ekf6mja9	135	7	nephritic	nephritic	JJ
cord-006702-ekf6mja9	135	8	rats	rat	NNS
cord-006702-ekf6mja9	135	9	on	on	IN
cord-006702-ekf6mja9	135	10	day	day	NN
cord-006702-ekf6mja9	135	11	8	8	CD
cord-006702-ekf6mja9	135	12	,	,	,
cord-006702-ekf6mja9	135	13	day	day	NN
cord-006702-ekf6mja9	135	14	14	14	CD
cord-006702-ekf6mja9	135	15	,	,	,
cord-006702-ekf6mja9	135	16	day	day	NN
cord-006702-ekf6mja9	135	17	21	21	CD
cord-006702-ekf6mja9	135	18	and	and	CC
cord-006702-ekf6mja9	135	19	day	day	NN
cord-006702-ekf6mja9	135	20	28	28	CD
cord-006702-ekf6mja9	135	21	and	and	CC
cord-006702-ekf6mja9	135	22	compared	compare	VBN
cord-006702-ekf6mja9	135	23	with	with	IN
cord-006702-ekf6mja9	135	24	samples	sample	NNS
cord-006702-ekf6mja9	135	25	from	from	IN
cord-006702-ekf6mja9	135	26	normal	normal	JJ
cord-006702-ekf6mja9	135	27	rats	rat	NNS
cord-006702-ekf6mja9	135	28	.	.	.
cord-006702-ekf6mja9	136	1	Corticosteroid	corticosteroid	JJ
cord-006702-ekf6mja9	136	2	treatment	treatment	NN
cord-006702-ekf6mja9	136	3	in	in	IN
cord-006702-ekf6mja9	136	4	experimental	experimental	JJ
cord-006702-ekf6mja9	136	5	GN	GN	NNP
cord-006702-ekf6mja9	136	6	:	:	:
cord-006702-ekf6mja9	136	7	(	(	-LRB-
cord-006702-ekf6mja9	136	8	1	1	LS
cord-006702-ekf6mja9	136	9	)	)	-RRB-
cord-006702-ekf6mja9	136	10	healthy	healthy	JJ
cord-006702-ekf6mja9	136	11	control	control	NN
cord-006702-ekf6mja9	136	12	group	group	NN
cord-006702-ekf6mja9	136	13	(	(	-LRB-
cord-006702-ekf6mja9	136	14	2	2	CD
cord-006702-ekf6mja9	136	15	)	)	-RRB-
cord-006702-ekf6mja9	136	16	treatment	treatment	NN
cord-006702-ekf6mja9	136	17	group	group	NN
cord-006702-ekf6mja9	136	18	:	:	:
cord-006702-ekf6mja9	136	19	NTN	NTN	NNP
cord-006702-ekf6mja9	136	20	rats	rat	NNS
cord-006702-ekf6mja9	136	21	treated	treat	VBN
cord-006702-ekf6mja9	136	22	with	with	IN
cord-006702-ekf6mja9	136	23	0.25	0.25	CD
cord-006702-ekf6mja9	136	24	mg/	mg/	NN
cord-006702-ekf6mja9	136	25	kg	kg	NN
cord-006702-ekf6mja9	136	26	of	of	IN
cord-006702-ekf6mja9	136	27	dexamethasone	dexamethasone	NNP
cord-006702-ekf6mja9	136	28	(	(	-LRB-
cord-006702-ekf6mja9	136	29	DXM	DXM	NNP
cord-006702-ekf6mja9	136	30	)	)	-RRB-
cord-006702-ekf6mja9	136	31	,	,	,
cord-006702-ekf6mja9	136	32	ip	ip	NN
cord-006702-ekf6mja9	136	33	every	every	DT
cord-006702-ekf6mja9	136	34	4	4	CD
cord-006702-ekf6mja9	136	35	days	day	NNS
cord-006702-ekf6mja9	136	36	,	,	,
cord-006702-ekf6mja9	136	37	and	and	CC
cord-006702-ekf6mja9	136	38	(	(	-LRB-
cord-006702-ekf6mja9	136	39	3	3	LS
cord-006702-ekf6mja9	136	40	)	)	-RRB-
cord-006702-ekf6mja9	136	41	vehicle	vehicle	NN
cord-006702-ekf6mja9	136	42	group	group	NN
cord-006702-ekf6mja9	136	43	:	:	:
cord-006702-ekf6mja9	136	44	NTN	NTN	NNP
cord-006702-ekf6mja9	136	45	rats	rat	NNS
cord-006702-ekf6mja9	136	46	treated	treat	VBN
cord-006702-ekf6mja9	136	47	with	with	IN
cord-006702-ekf6mja9	136	48	PBS	PBS	NNP
cord-006702-ekf6mja9	136	49	,	,	,
cord-006702-ekf6mja9	136	50	ip	ip	NN
cord-006702-ekf6mja9	136	51	every	every	DT
cord-006702-ekf6mja9	136	52	4	4	CD
cord-006702-ekf6mja9	136	53	days	day	NNS
cord-006702-ekf6mja9	136	54	.	.	.
cord-006702-ekf6mja9	137	1	A	a	DT
cord-006702-ekf6mja9	137	2	series	series	NN
cord-006702-ekf6mja9	137	3	of	of	IN
cord-006702-ekf6mja9	137	4	urine	urine	NN
cord-006702-ekf6mja9	137	5	was	be	VBD
cord-006702-ekf6mja9	137	6	collected	collect	VBN
cord-006702-ekf6mja9	137	7	and	and	CC
cord-006702-ekf6mja9	137	8	plasma	plasma	NN
cord-006702-ekf6mja9	137	9	samples	sample	NNS
cord-006702-ekf6mja9	137	10	were	be	VBD
cord-006702-ekf6mja9	137	11	taken	take	VBN
cord-006702-ekf6mja9	137	12	at	at	IN
cord-006702-ekf6mja9	137	13	the	the	DT
cord-006702-ekf6mja9	137	14	time	time	NN
cord-006702-ekf6mja9	137	15	of	of	IN
cord-006702-ekf6mja9	137	16	cull	cull	NN
cord-006702-ekf6mja9	137	17	.	.	.
cord-006702-ekf6mja9	138	1	Sample	sample	JJ
cord-006702-ekf6mja9	138	2	spectra	spectrum	NNS
cord-006702-ekf6mja9	138	3	were	be	VBD
cord-006702-ekf6mja9	138	4	recored	recore	VBN
cord-006702-ekf6mja9	138	5	by	by	IN
cord-006702-ekf6mja9	138	6	FTIR	FTIR	NNP
cord-006702-ekf6mja9	138	7	spectrometer	spectrometer	NN
cord-006702-ekf6mja9	138	8	and	and	CC
cord-006702-ekf6mja9	138	9	data	datum	NNS
cord-006702-ekf6mja9	138	10	was	be	VBD
cord-006702-ekf6mja9	138	11	anayzed	anayze	VBN
cord-006702-ekf6mja9	138	12	using	use	VBG
cord-006702-ekf6mja9	138	13	Origin	Origin	NNP
cord-006702-ekf6mja9	138	14	9.1	9.1	CD
cord-006702-ekf6mja9	138	15	.	.	.
cord-006702-ekf6mja9	139	1	Results	result	NNS
cord-006702-ekf6mja9	139	2	:	:	:
cord-006702-ekf6mja9	140	1	Three	three	CD
cord-006702-ekf6mja9	140	2	spectral	spectral	JJ
cord-006702-ekf6mja9	140	3	markers	marker	NNS
cord-006702-ekf6mja9	140	4	at	at	IN
cord-006702-ekf6mja9	140	5	1668	1668	CD
cord-006702-ekf6mja9	140	6	cm	cm	NNS
cord-006702-ekf6mja9	140	7	-1	-1	NN
cord-006702-ekf6mja9	140	8	,	,	,
cord-006702-ekf6mja9	141	1	1545	1545	CD
cord-006702-ekf6mja9	141	2	cm	cm	NNP
cord-006702-ekf6mja9	141	3	-1	-1	CD
cord-006702-ekf6mja9	141	4	and	and	CC
cord-006702-ekf6mja9	141	5	1033	1033	CD
cord-006702-ekf6mja9	141	6	cm	cm	NNS
cord-006702-ekf6mja9	141	7	-1	-1	NN
cord-006702-ekf6mja9	141	8	were	be	VBD
cord-006702-ekf6mja9	141	9	identified	identify	VBN
cord-006702-ekf6mja9	141	10	in	in	IN
cord-006702-ekf6mja9	141	11	urine	urine	NN
cord-006702-ekf6mja9	141	12	and	and	CC
cord-006702-ekf6mja9	141	13	their	-PRON-	PRP$
cord-006702-ekf6mja9	141	14	intensity	intensity	NN
cord-006702-ekf6mja9	141	15	changes	change	NNS
cord-006702-ekf6mja9	141	16	were	be	VBD
cord-006702-ekf6mja9	141	17	in	in	IN
cord-006702-ekf6mja9	141	18	accordance	accordance	NN
cord-006702-ekf6mja9	141	19	to	to	IN
cord-006702-ekf6mja9	141	20	acute	acute	JJ
cord-006702-ekf6mja9	141	21	renal	renal	JJ
cord-006702-ekf6mja9	141	22	injury	injury	NN
cord-006702-ekf6mja9	141	23	,	,	,
cord-006702-ekf6mja9	141	24	progressive	progressive	JJ
cord-006702-ekf6mja9	141	25	renal	renal	JJ
cord-006702-ekf6mja9	141	26	injury	injury	NN
cord-006702-ekf6mja9	141	27	and	and	CC
cord-006702-ekf6mja9	141	28	chronic	chronic	JJ
cord-006702-ekf6mja9	141	29	renal	renal	JJ
cord-006702-ekf6mja9	141	30	failure	failure	NN
cord-006702-ekf6mja9	141	31	,	,	,
cord-006702-ekf6mja9	141	32	respectively	respectively	RB
cord-006702-ekf6mja9	141	33	.	.	.
cord-006702-ekf6mja9	142	1	In	in	IN
cord-006702-ekf6mja9	142	2	particular	particular	JJ
cord-006702-ekf6mja9	142	3	,	,	,
cord-006702-ekf6mja9	142	4	the	the	DT
cord-006702-ekf6mja9	142	5	intensity	intensity	NN
cord-006702-ekf6mja9	142	6	of	of	IN
cord-006702-ekf6mja9	142	7	urinary	urinary	JJ
cord-006702-ekf6mja9	142	8	1545	1545	CD
cord-006702-ekf6mja9	142	9	cm	cm	NNS
cord-006702-ekf6mja9	142	10	-1	-1	NN
cord-006702-ekf6mja9	142	11	marker	marker	NN
cord-006702-ekf6mja9	142	12	was	be	VBD
cord-006702-ekf6mja9	142	13	reduced	reduce	VBN
cord-006702-ekf6mja9	142	14	in	in	IN
cord-006702-ekf6mja9	142	15	response	response	NN
cord-006702-ekf6mja9	142	16	to	to	IN
cord-006702-ekf6mja9	142	17	DXM	DXM	NNP
cord-006702-ekf6mja9	142	18	treatment	treatment	NN
cord-006702-ekf6mja9	142	19	.	.	.
cord-006702-ekf6mja9	143	1	Besides	besides	RB
cord-006702-ekf6mja9	143	2	,	,	,
cord-006702-ekf6mja9	143	3	there	there	EX
cord-006702-ekf6mja9	143	4	were	be	VBD
cord-006702-ekf6mja9	143	5	three	three	CD
cord-006702-ekf6mja9	143	6	potential	potential	JJ
cord-006702-ekf6mja9	143	7	plasma	plasma	NN
cord-006702-ekf6mja9	143	8	spectral	spectral	JJ
cord-006702-ekf6mja9	143	9	markers	marker	NNS
cord-006702-ekf6mja9	143	10	identified	identify	VBN
cord-006702-ekf6mja9	143	11	at	at	IN
cord-006702-ekf6mja9	143	12	1705	1705	CD
cord-006702-ekf6mja9	143	13	,	,	,
cord-006702-ekf6mja9	143	14	1460	1460	CD
cord-006702-ekf6mja9	143	15	and	and	CC
cord-006702-ekf6mja9	143	16	1240	1240	CD
cord-006702-ekf6mja9	143	17	cm	cm	NNS
cord-006702-ekf6mja9	143	18	-1	-1	NN
cord-006702-ekf6mja9	143	19	,	,	,
cord-006702-ekf6mja9	143	20	respectively	respectively	RB
cord-006702-ekf6mja9	143	21	,	,	,
cord-006702-ekf6mja9	143	22	showing	show	VBG
cord-006702-ekf6mja9	143	23	that	that	IN
cord-006702-ekf6mja9	143	24	their	-PRON-	PRP$
cord-006702-ekf6mja9	143	25	intensity	intensity	NN
cord-006702-ekf6mja9	143	26	changes	change	NNS
cord-006702-ekf6mja9	143	27	were	be	VBD
cord-006702-ekf6mja9	143	28	parallel	parallel	JJ
cord-006702-ekf6mja9	143	29	to	to	IN
cord-006702-ekf6mja9	143	30	the	the	DT
cord-006702-ekf6mja9	143	31	deterioration	deterioration	NN
cord-006702-ekf6mja9	143	32	of	of	IN
cord-006702-ekf6mja9	143	33	renal	renal	JJ
cord-006702-ekf6mja9	143	34	injury	injury	NN
cord-006702-ekf6mja9	143	35	.	.	.
cord-006702-ekf6mja9	144	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	144	2	:	:	:
cord-006702-ekf6mja9	145	1	The	the	DT
cord-006702-ekf6mja9	145	2	specific	specific	JJ
cord-006702-ekf6mja9	145	3	urinary	urinary	JJ
cord-006702-ekf6mja9	145	4	/	/	SYM
cord-006702-ekf6mja9	145	5	plasma	plasma	NN
cord-006702-ekf6mja9	145	6	FTIR	ftir	NN
cord-006702-ekf6mja9	145	7	biomarkers	biomarker	NNS
cord-006702-ekf6mja9	145	8	can	can	MD
cord-006702-ekf6mja9	145	9	be	be	VB
cord-006702-ekf6mja9	145	10	the	the	DT
cord-006702-ekf6mja9	145	11	noninvasive	noninvasive	JJ
cord-006702-ekf6mja9	145	12	and	and	CC
cord-006702-ekf6mja9	145	13	sensitive	sensitive	JJ
cord-006702-ekf6mja9	145	14	approach	approach	NN
cord-006702-ekf6mja9	145	15	of	of	IN
cord-006702-ekf6mja9	145	16	early	early	JJ
cord-006702-ekf6mja9	145	17	diagnosing	diagnosing	NN
cord-006702-ekf6mja9	145	18	and/or	and/or	CC
cord-006702-ekf6mja9	145	19	real	real	JJ
cord-006702-ekf6mja9	145	20	-	-	HYPH
cord-006702-ekf6mja9	145	21	time	time	NN
cord-006702-ekf6mja9	145	22	monitoringprogressive	monitoringprogressive	JJ
cord-006702-ekf6mja9	145	23	kidney	kidney	NN
cord-006702-ekf6mja9	145	24	disease	disease	NN
cord-006702-ekf6mja9	145	25	.	.	.
cord-006702-ekf6mja9	146	1	Objectives	objective	NNS
cord-006702-ekf6mja9	146	2	:	:	:
cord-006702-ekf6mja9	146	3	Although	although	IN
cord-006702-ekf6mja9	146	4	ESI	ESI	NNP
cord-006702-ekf6mja9	146	5	has	have	VBZ
cord-006702-ekf6mja9	146	6	been	be	VBN
cord-006702-ekf6mja9	146	7	linked	link	VBN
cord-006702-ekf6mja9	146	8	to	to	IN
cord-006702-ekf6mja9	146	9	peritonitis	peritonitis	NN
cord-006702-ekf6mja9	146	10	in	in	IN
cord-006702-ekf6mja9	146	11	pediatric	pediatric	JJ
cord-006702-ekf6mja9	146	12	PD	PD	NNP
cord-006702-ekf6mja9	146	13	,	,	,
cord-006702-ekf6mja9	146	14	little	little	JJ
cord-006702-ekf6mja9	146	15	data	data	NN
cord-006702-ekf6mja9	146	16	exists	exist	VBZ
cord-006702-ekf6mja9	146	17	as	as	IN
cord-006702-ekf6mja9	146	18	to	to	IN
cord-006702-ekf6mja9	146	19	ESI	ESI	NNP
cord-006702-ekf6mja9	146	20	frequency	frequency	NN
cord-006702-ekf6mja9	146	21	and	and	CC
cord-006702-ekf6mja9	146	22	clinical	clinical	JJ
cord-006702-ekf6mja9	146	23	factors	factor	NNS
cord-006702-ekf6mja9	146	24	influencing	influence	VBG
cord-006702-ekf6mja9	146	25	its	-PRON-	PRP$
cord-006702-ekf6mja9	146	26	manifestation	manifestation	NN
cord-006702-ekf6mja9	146	27	.	.	.
cord-006702-ekf6mja9	147	1	SCOPE	SCOPE	NNP
cord-006702-ekf6mja9	147	2	aims	aim	VBZ
cord-006702-ekf6mja9	147	3	to	to	TO
cord-006702-ekf6mja9	147	4	reduce	reduce	VB
cord-006702-ekf6mja9	147	5	PD	PD	NNP
cord-006702-ekf6mja9	147	6	-	-	HYPH
cord-006702-ekf6mja9	147	7	associated	associate	VBN
cord-006702-ekf6mja9	147	8	infections	infection	NNS
cord-006702-ekf6mja9	147	9	through	through	IN
cord-006702-ekf6mja9	147	10	the	the	DT
cord-006702-ekf6mja9	147	11	systematic	systematic	JJ
cord-006702-ekf6mja9	147	12	implementation	implementation	NN
cord-006702-ekf6mja9	147	13	of	of	IN
cord-006702-ekf6mja9	147	14	standardized	standardized	JJ
cord-006702-ekf6mja9	147	15	care	care	NN
cord-006702-ekf6mja9	147	16	practices	practice	NNS
cord-006702-ekf6mja9	147	17	,	,	,
cord-006702-ekf6mja9	147	18	including	include	VBG
cord-006702-ekf6mja9	147	19	stipulated	stipulate	VBN
cord-006702-ekf6mja9	147	20	ES	ES	NNP
cord-006702-ekf6mja9	147	21	care	care	NN
cord-006702-ekf6mja9	147	22	and	and	CC
cord-006702-ekf6mja9	147	23	an	an	DT
cord-006702-ekf6mja9	147	24	ES	es	NN
cord-006702-ekf6mja9	147	25	-	-	HYPH
cord-006702-ekf6mja9	147	26	scoring	score	VBG
cord-006702-ekf6mja9	147	27	tool	tool	NN
cord-006702-ekf6mja9	147	28	.	.	.
cord-006702-ekf6mja9	148	1	We	-PRON-	PRP
cord-006702-ekf6mja9	148	2	sought	seek	VBD
cord-006702-ekf6mja9	148	3	to	to	TO
cord-006702-ekf6mja9	148	4	elucidate	elucidate	VB
cord-006702-ekf6mja9	148	5	ESI	ESI	NNP
cord-006702-ekf6mja9	148	6	rates	rate	NNS
cord-006702-ekf6mja9	148	7	,	,	,
cord-006702-ekf6mja9	148	8	predisposing	predispose	VBG
cord-006702-ekf6mja9	148	9	clinical	clinical	JJ
cord-006702-ekf6mja9	148	10	factors	factor	NNS
cord-006702-ekf6mja9	148	11	,	,	,
cord-006702-ekf6mja9	148	12	and	and	CC
cord-006702-ekf6mja9	148	13	ESI	ESI	NNP
cord-006702-ekf6mja9	148	14	outcomes	outcome	NNS
cord-006702-ekf6mja9	148	15	in	in	IN
cord-006702-ekf6mja9	148	16	children	child	NNS
cord-006702-ekf6mja9	148	17	on	on	IN
cord-006702-ekf6mja9	148	18	PD	PD	NNP
cord-006702-ekf6mja9	148	19	.	.	.
cord-006702-ekf6mja9	149	1	Methods	method	NNS
cord-006702-ekf6mja9	149	2	:	:	:
cord-006702-ekf6mja9	149	3	SCOPE	SCOPE	NNP
cord-006702-ekf6mja9	149	4	data	data	NN
cord-006702-ekf6mja9	149	5	collected10/1/11	collected10/1/11	NNS
cord-006702-ekf6mja9	150	1	-9/30/14	-9/30/14	NNP
cord-006702-ekf6mja9	150	2	were	be	VBD
cord-006702-ekf6mja9	150	3	analyzed	analyze	VBN
cord-006702-ekf6mja9	150	4	,	,	,
cord-006702-ekf6mja9	150	5	including	include	VBG
cord-006702-ekf6mja9	150	6	demographic	demographic	JJ
cord-006702-ekf6mja9	150	7	and	and	CC
cord-006702-ekf6mja9	150	8	infection	infection	NN
cord-006702-ekf6mja9	150	9	detail	detail	NN
cord-006702-ekf6mja9	150	10	.	.	.
cord-006702-ekf6mja9	151	1	ESI	ESI	NNP
cord-006702-ekf6mja9	151	2	was	be	VBD
cord-006702-ekf6mja9	151	3	defined	define	VBN
cord-006702-ekf6mja9	151	4	as	as	IN
cord-006702-ekf6mja9	151	5	purulent	purulent	JJ
cord-006702-ekf6mja9	151	6	drainage	drainage	NN
cord-006702-ekf6mja9	151	7	or	or	CC
cord-006702-ekf6mja9	151	8	exit	exit	NN
cord-006702-ekf6mja9	151	9	site	site	NN
cord-006702-ekf6mja9	151	10	score	score	NN
cord-006702-ekf6mja9	151	11	>	>	XX
cord-006702-ekf6mja9	151	12	4	4	CD
cord-006702-ekf6mja9	151	13	or	or	CC
cord-006702-ekf6mja9	151	14	treatment	treatment	NN
cord-006702-ekf6mja9	151	15	for	for	IN
cord-006702-ekf6mja9	151	16	ESI	ESI	NNP
cord-006702-ekf6mja9	151	17	.	.	.
cord-006702-ekf6mja9	152	1	FP	FP	NNP
cord-006702-ekf6mja9	152	2	-	-	HYPH
cord-006702-ekf6mja9	152	3	S07	S07	NNP
cord-006702-ekf6mja9	152	4	-	-	HYPH
cord-006702-ekf6mja9	152	5	2	2	CD
cord-006702-ekf6mja9	153	1	The	the	DT
cord-006702-ekf6mja9	153	2	role	role	NN
cord-006702-ekf6mja9	153	3	of	of	IN
cord-006702-ekf6mja9	153	4	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	153	5	biopsy	biopsy	NN
cord-006702-ekf6mja9	153	6	for	for	IN
cord-006702-ekf6mja9	153	7	the	the	DT
cord-006702-ekf6mja9	153	8	pediatric	pediatric	JJ
cord-006702-ekf6mja9	153	9	patients	patient	NNS
cord-006702-ekf6mja9	153	10	on	on	IN
cord-006702-ekf6mja9	153	11	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	153	12	dialysis	dialysis	NN
cord-006702-ekf6mja9	153	13	suspected	suspect	VBN
cord-006702-ekf6mja9	153	14	of	of	IN
cord-006702-ekf6mja9	153	15	Encapsulating	encapsulate	VBG
cord-006702-ekf6mja9	153	16	Peritoneal	Peritoneal	NNP
cord-006702-ekf6mja9	153	17	Sclerosis	Sclerosis	NNP
cord-006702-ekf6mja9	153	18	.	.	.
cord-006702-ekf6mja9	154	1	R.	R.	NNP
cord-006702-ekf6mja9	154	2	Harada	Harada	NNP
cord-006702-ekf6mja9	154	3	(	(	-LRB-
cord-006702-ekf6mja9	154	4	1	1	CD
cord-006702-ekf6mja9	154	5	)	)	-RRB-
cord-006702-ekf6mja9	154	6	,	,	,
cord-006702-ekf6mja9	154	7	R.	R.	NNP
cord-006702-ekf6mja9	154	8	Hamada	Hamada	NNP
cord-006702-ekf6mja9	154	9	(	(	-LRB-
cord-006702-ekf6mja9	154	10	1	1	CD
cord-006702-ekf6mja9	154	11	)	)	-RRB-
cord-006702-ekf6mja9	154	12	,	,	,
cord-006702-ekf6mja9	154	13	H.	H.	NNP
cord-006702-ekf6mja9	154	14	Satoh	Satoh	NNP
cord-006702-ekf6mja9	154	15	(	(	-LRB-
cord-006702-ekf6mja9	154	16	1	1	CD
cord-006702-ekf6mja9	154	17	)	)	-RRB-
cord-006702-ekf6mja9	154	18	,	,	,
cord-006702-ekf6mja9	154	19	Y.	Y.	NNP
cord-006702-ekf6mja9	154	20	Hamasaki	Hamasaki	NNP
cord-006702-ekf6mja9	154	21	(	(	-LRB-
cord-006702-ekf6mja9	154	22	2	2	CD
cord-006702-ekf6mja9	154	23	)	)	-RRB-
cord-006702-ekf6mja9	154	24	,	,	,
cord-006702-ekf6mja9	154	25	K.	K.	NNP
cord-006702-ekf6mja9	154	26	Ishikura	Ishikura	NNP
cord-006702-ekf6mja9	154	27	(	(	-LRB-
cord-006702-ekf6mja9	154	28	3	3	CD
cord-006702-ekf6mja9	154	29	)	)	-RRB-
cord-006702-ekf6mja9	154	30	,	,	,
cord-006702-ekf6mja9	154	31	H.	H.	NNP
cord-006702-ekf6mja9	154	32	Hataya	Hataya	NNP
cord-006702-ekf6mja9	154	33	(	(	-LRB-
cord-006702-ekf6mja9	154	34	1	1	CD
cord-006702-ekf6mja9	154	35	)	)	-RRB-
cord-006702-ekf6mja9	154	36	,	,	,
cord-006702-ekf6mja9	154	37	R.	R.	NNP
cord-006702-ekf6mja9	154	38	Fukuzawa	Fukuzawa	NNP
cord-006702-ekf6mja9	154	39	(	(	-LRB-
cord-006702-ekf6mja9	154	40	1	1	CD
cord-006702-ekf6mja9	154	41	)	)	-RRB-
cord-006702-ekf6mja9	154	42	,	,	,
cord-006702-ekf6mja9	154	43	M.	M.	NNP
cord-006702-ekf6mja9	154	44	Honda	Honda	NNP
cord-006702-ekf6mja9	154	45	(	(	-LRB-
cord-006702-ekf6mja9	154	46	1	1	CD
cord-006702-ekf6mja9	154	47	)	)	-RRB-
cord-006702-ekf6mja9	155	1	(	(	-LRB-
cord-006702-ekf6mja9	155	2	1	1	CD
cord-006702-ekf6mja9	155	3	)	)	-RRB-
cord-006702-ekf6mja9	156	1	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	156	2	Metropolitan	Metropolitan	NNP
cord-006702-ekf6mja9	156	3	Children	Children	NNPS
cord-006702-ekf6mja9	156	4	's	's	POS
cord-006702-ekf6mja9	156	5	Medical	Medical	NNP
cord-006702-ekf6mja9	156	6	Center	Center	NNP
cord-006702-ekf6mja9	156	7	,	,	,
cord-006702-ekf6mja9	156	8	Fuchu	Fuchu	NNP
cord-006702-ekf6mja9	156	9	-	-	HYPH
cord-006702-ekf6mja9	156	10	Shi	Shi	NNP
cord-006702-ekf6mja9	156	11	,	,	,
cord-006702-ekf6mja9	156	12	Japan	Japan	NNP
cord-006702-ekf6mja9	156	13	;	;	:
cord-006702-ekf6mja9	156	14	(	(	-LRB-
cord-006702-ekf6mja9	156	15	2	2	LS
cord-006702-ekf6mja9	156	16	)	)	-RRB-
cord-006702-ekf6mja9	157	1	Toho	Toho	NNP
cord-006702-ekf6mja9	157	2	University	University	NNP
cord-006702-ekf6mja9	157	3	Faculty	Faculty	NNP
cord-006702-ekf6mja9	157	4	of	of	IN
cord-006702-ekf6mja9	157	5	Medicine	Medicine	NNP
cord-006702-ekf6mja9	157	6	,	,	,
cord-006702-ekf6mja9	157	7	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	157	8	,	,	,
cord-006702-ekf6mja9	157	9	Japan	Japan	NNP
cord-006702-ekf6mja9	157	10	;	;	:
cord-006702-ekf6mja9	157	11	(	(	-LRB-
cord-006702-ekf6mja9	157	12	3	3	LS
cord-006702-ekf6mja9	157	13	)	)	-RRB-
cord-006702-ekf6mja9	157	14	National	National	NNP
cord-006702-ekf6mja9	157	15	Center	Center	NNP
cord-006702-ekf6mja9	157	16	for	for	IN
cord-006702-ekf6mja9	157	17	Child	Child	NNP
cord-006702-ekf6mja9	157	18	Health	Health	NNP
cord-006702-ekf6mja9	157	19	and	and	CC
cord-006702-ekf6mja9	157	20	Development	Development	NNP
cord-006702-ekf6mja9	157	21	,	,	,
cord-006702-ekf6mja9	157	22	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	157	23	,	,	,
cord-006702-ekf6mja9	157	24	Japan	Japan	NNP
cord-006702-ekf6mja9	157	25	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	157	26	:	:	:
cord-006702-ekf6mja9	158	1	To	to	TO
cord-006702-ekf6mja9	158	2	evaluate	evaluate	VB
cord-006702-ekf6mja9	158	3	the	the	DT
cord-006702-ekf6mja9	158	4	usefulness	usefulness	NN
cord-006702-ekf6mja9	158	5	of	of	IN
cord-006702-ekf6mja9	158	6	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	158	7	biopsy	biopsy	NN
cord-006702-ekf6mja9	158	8	in	in	IN
cord-006702-ekf6mja9	158	9	Japanese	japanese	JJ
cord-006702-ekf6mja9	158	10	pediatric	pediatric	JJ
cord-006702-ekf6mja9	158	11	patients	patient	NNS
cord-006702-ekf6mja9	158	12	on	on	IN
cord-006702-ekf6mja9	158	13	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	158	14	dialysis	dialysis	NN
cord-006702-ekf6mja9	158	15	(	(	-LRB-
cord-006702-ekf6mja9	158	16	PD	PD	NNP
cord-006702-ekf6mja9	158	17	)	)	-RRB-
cord-006702-ekf6mja9	158	18	suspected	suspect	VBN
cord-006702-ekf6mja9	158	19	of	of	IN
cord-006702-ekf6mja9	158	20	Encapsulating	encapsulate	VBG
cord-006702-ekf6mja9	158	21	Peritoneal	Peritoneal	NNP
cord-006702-ekf6mja9	158	22	Sclerosis	Sclerosis	NNP
cord-006702-ekf6mja9	158	23	(	(	-LRB-
cord-006702-ekf6mja9	158	24	EPS	EPS	NNP
cord-006702-ekf6mja9	158	25	)	)	-RRB-
cord-006702-ekf6mja9	158	26	.	.	.
cord-006702-ekf6mja9	159	1	Methods	method	NNS
cord-006702-ekf6mja9	159	2	:	:	:
cord-006702-ekf6mja9	160	1	We	-PRON-	PRP
cord-006702-ekf6mja9	160	2	retrospectively	retrospectively	RB
cord-006702-ekf6mja9	160	3	studied	study	VBD
cord-006702-ekf6mja9	160	4	the	the	DT
cord-006702-ekf6mja9	160	5	data	datum	NNS
cord-006702-ekf6mja9	160	6	from	from	IN
cord-006702-ekf6mja9	160	7	children	child	NNS
cord-006702-ekf6mja9	160	8	who	who	WP
cord-006702-ekf6mja9	160	9	underwent	undergo	VBD
cord-006702-ekf6mja9	160	10	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	160	11	biopsy	biopsy	NN
cord-006702-ekf6mja9	160	12	from	from	IN
cord-006702-ekf6mja9	160	13	January	January	NNP
cord-006702-ekf6mja9	160	14	1979	1979	CD
cord-006702-ekf6mja9	160	15	to	to	IN
cord-006702-ekf6mja9	160	16	December	December	NNP
cord-006702-ekf6mja9	160	17	2014	2014	CD
cord-006702-ekf6mja9	160	18	at	at	IN
cord-006702-ekf6mja9	160	19	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	160	20	Metropolitan	Metropolitan	NNP
cord-006702-ekf6mja9	160	21	Children	Children	NNPS
cord-006702-ekf6mja9	160	22	's	's	POS
cord-006702-ekf6mja9	160	23	Medical	Medical	NNP
cord-006702-ekf6mja9	160	24	Center	Center	NNP
cord-006702-ekf6mja9	160	25	.	.	.
cord-006702-ekf6mja9	161	1	All	all	DT
cord-006702-ekf6mja9	161	2	patients	patient	NNS
cord-006702-ekf6mja9	161	3	had	have	VBD
cord-006702-ekf6mja9	161	4	at	at	RB
cord-006702-ekf6mja9	161	5	least	least	RBS
cord-006702-ekf6mja9	161	6	one	one	CD
cord-006702-ekf6mja9	161	7	of	of	IN
cord-006702-ekf6mja9	161	8	the	the	DT
cord-006702-ekf6mja9	161	9	following	follow	VBG
cord-006702-ekf6mja9	161	10	characteristics	characteristic	NNS
cord-006702-ekf6mja9	161	11	,	,	,
cord-006702-ekf6mja9	161	12	clinical	clinical	JJ
cord-006702-ekf6mja9	161	13	symptoms	symptom	NNS
cord-006702-ekf6mja9	161	14	of	of	IN
cord-006702-ekf6mja9	161	15	EPS	EPS	NNP
cord-006702-ekf6mja9	161	16	,	,	,
cord-006702-ekf6mja9	161	17	poor	poor	JJ
cord-006702-ekf6mja9	161	18	ultrafiltration	ultrafiltration	NN
cord-006702-ekf6mja9	161	19	and	and	CC
cord-006702-ekf6mja9	161	20	a	a	DT
cord-006702-ekf6mja9	161	21	long	long	JJ
cord-006702-ekf6mja9	161	22	period	period	NN
cord-006702-ekf6mja9	161	23	of	of	IN
cord-006702-ekf6mja9	161	24	PD	PD	NNP
cord-006702-ekf6mja9	161	25	(	(	-LRB-
cord-006702-ekf6mja9	161	26	more	more	JJR
cord-006702-ekf6mja9	161	27	than	than	IN
cord-006702-ekf6mja9	161	28	5	5	CD
cord-006702-ekf6mja9	161	29	years	year	NNS
cord-006702-ekf6mja9	161	30	)	)	-RRB-
cord-006702-ekf6mja9	161	31	.	.	.
cord-006702-ekf6mja9	162	1	The	the	DT
cord-006702-ekf6mja9	162	2	results	result	NNS
cord-006702-ekf6mja9	162	3	were	be	VBD
cord-006702-ekf6mja9	162	4	divided	divide	VBN
cord-006702-ekf6mja9	162	5	into	into	IN
cord-006702-ekf6mja9	162	6	an	an	DT
cord-006702-ekf6mja9	162	7	existing	exist	VBG
cord-006702-ekf6mja9	162	8	symptoms	symptom	NNS
cord-006702-ekf6mja9	162	9	group	group	NN
cord-006702-ekf6mja9	162	10	and	and	CC
cord-006702-ekf6mja9	162	11	an	an	DT
cord-006702-ekf6mja9	162	12	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	162	13	group	group	NN
cord-006702-ekf6mja9	162	14	based	base	VBN
cord-006702-ekf6mja9	162	15	on	on	IN
cord-006702-ekf6mja9	162	16	their	-PRON-	PRP$
cord-006702-ekf6mja9	162	17	clinical	clinical	JJ
cord-006702-ekf6mja9	162	18	symptoms	symptom	NNS
cord-006702-ekf6mja9	162	19	of	of	IN
cord-006702-ekf6mja9	162	20	EPS	eps	NN
cord-006702-ekf6mja9	162	21	such	such	JJ
cord-006702-ekf6mja9	162	22	as	as	IN
cord-006702-ekf6mja9	162	23	vomiting	vomiting	NN
cord-006702-ekf6mja9	162	24	and/or	and/or	CC
cord-006702-ekf6mja9	162	25	bloody	bloody	JJ
cord-006702-ekf6mja9	162	26	ascites	ascite	NNS
cord-006702-ekf6mja9	162	27	.	.	.
cord-006702-ekf6mja9	163	1	We	-PRON-	PRP
cord-006702-ekf6mja9	163	2	compared	compare	VBD
cord-006702-ekf6mja9	163	3	the	the	DT
cord-006702-ekf6mja9	163	4	pathological	pathological	JJ
cord-006702-ekf6mja9	163	5	results	result	NNS
cord-006702-ekf6mja9	163	6	and	and	CC
cord-006702-ekf6mja9	163	7	the	the	DT
cord-006702-ekf6mja9	163	8	treatment	treatment	NN
cord-006702-ekf6mja9	163	9	after	after	IN
cord-006702-ekf6mja9	163	10	biopsy	biopsy	NN
cord-006702-ekf6mja9	163	11	of	of	IN
cord-006702-ekf6mja9	163	12	two	two	CD
cord-006702-ekf6mja9	163	13	groups	group	NNS
cord-006702-ekf6mja9	163	14	.	.	.
cord-006702-ekf6mja9	164	1	Results	result	NNS
cord-006702-ekf6mja9	164	2	:	:	:
cord-006702-ekf6mja9	165	1	Fifty	fifty	CD
cord-006702-ekf6mja9	165	2	-	-	HYPH
cord-006702-ekf6mja9	165	3	four	four	CD
cord-006702-ekf6mja9	165	4	cases	case	NNS
cord-006702-ekf6mja9	165	5	were	be	VBD
cord-006702-ekf6mja9	165	6	reviewed	review	VBN
cord-006702-ekf6mja9	165	7	in	in	IN
cord-006702-ekf6mja9	165	8	this	this	DT
cord-006702-ekf6mja9	165	9	study	study	NN
cord-006702-ekf6mja9	165	10	.	.	.
cord-006702-ekf6mja9	166	1	The	the	DT
cord-006702-ekf6mja9	166	2	median	median	JJ
cord-006702-ekf6mja9	166	3	age	age	NN
cord-006702-ekf6mja9	166	4	at	at	IN
cord-006702-ekf6mja9	166	5	introduction	introduction	NN
cord-006702-ekf6mja9	166	6	of	of	IN
cord-006702-ekf6mja9	166	7	PD	PD	NNP
cord-006702-ekf6mja9	166	8	was	be	VBD
cord-006702-ekf6mja9	166	9	8.0	8.0	CD
cord-006702-ekf6mja9	167	1	(	(	-LRB-
cord-006702-ekf6mja9	167	2	range	range	VBP
cord-006702-ekf6mja9	167	3	0.0	0.0	CD
cord-006702-ekf6mja9	167	4	-	-	HYPH
cord-006702-ekf6mja9	167	5	25.9	25.9	CD
cord-006702-ekf6mja9	167	6	years	year	NNS
cord-006702-ekf6mja9	167	7	)	)	-RRB-
cord-006702-ekf6mja9	167	8	.	.	.
cord-006702-ekf6mja9	168	1	Ten	ten	CD
cord-006702-ekf6mja9	168	2	cases	case	NNS
cord-006702-ekf6mja9	168	3	were	be	VBD
cord-006702-ekf6mja9	168	4	existing	exist	VBG
cord-006702-ekf6mja9	168	5	symptoms	symptom	NNS
cord-006702-ekf6mja9	168	6	,	,	,
cord-006702-ekf6mja9	168	7	while	while	IN
cord-006702-ekf6mja9	168	8	44	44	CD
cord-006702-ekf6mja9	168	9	were	be	VBD
cord-006702-ekf6mja9	168	10	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	168	11	before	before	IN
cord-006702-ekf6mja9	168	12	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	168	13	biopsy	biopsy	NN
cord-006702-ekf6mja9	168	14	.	.	.
cord-006702-ekf6mja9	169	1	At	at	IN
cord-006702-ekf6mja9	169	2	the	the	DT
cord-006702-ekf6mja9	169	3	biopsy	biopsy	NN
cord-006702-ekf6mja9	169	4	,	,	,
cord-006702-ekf6mja9	169	5	the	the	DT
cord-006702-ekf6mja9	169	6	median	median	JJ
cord-006702-ekf6mja9	169	7	duration	duration	NN
cord-006702-ekf6mja9	169	8	of	of	IN
cord-006702-ekf6mja9	169	9	PD	PD	NNP
cord-006702-ekf6mja9	169	10	continuation	continuation	NN
cord-006702-ekf6mja9	169	11	was	be	VBD
cord-006702-ekf6mja9	169	12	7.0	7.0	CD
cord-006702-ekf6mja9	169	13	years	year	NNS
cord-006702-ekf6mja9	169	14	(	(	-LRB-
cord-006702-ekf6mja9	169	15	5.5	5.5	CD
cord-006702-ekf6mja9	169	16	-	-	SYM
cord-006702-ekf6mja9	169	17	12.1	12.1	CD
cord-006702-ekf6mja9	169	18	)	)	-RRB-
cord-006702-ekf6mja9	169	19	and	and	CC
cord-006702-ekf6mja9	169	20	5.7	5.7	CD
cord-006702-ekf6mja9	169	21	years	year	NNS
cord-006702-ekf6mja9	169	22	(	(	-LRB-
cord-006702-ekf6mja9	169	23	0.6	0.6	CD
cord-006702-ekf6mja9	169	24	-	-	SYM
cord-006702-ekf6mja9	169	25	15.7	15.7	CD
cord-006702-ekf6mja9	169	26	)	)	-RRB-
cord-006702-ekf6mja9	169	27	respectively	respectively	RB
cord-006702-ekf6mja9	169	28	.	.	.
cord-006702-ekf6mja9	170	1	In	in	IN
cord-006702-ekf6mja9	170	2	both	both	DT
cord-006702-ekf6mja9	170	3	groups	group	NNS
cord-006702-ekf6mja9	170	4	,	,	,
cord-006702-ekf6mja9	170	5	most	most	JJS
cord-006702-ekf6mja9	170	6	of	of	IN
cord-006702-ekf6mja9	170	7	the	the	DT
cord-006702-ekf6mja9	170	8	biopsy	biopsy	NN
cord-006702-ekf6mja9	170	9	results	result	NNS
cord-006702-ekf6mja9	170	10	showed	show	VBD
cord-006702-ekf6mja9	170	11	mesothelial	mesothelial	JJ
cord-006702-ekf6mja9	170	12	denudation	denudation	NN
cord-006702-ekf6mja9	170	13	,	,	,
cord-006702-ekf6mja9	170	14	interstitial	interstitial	JJ
cord-006702-ekf6mja9	170	15	fibrosis	fibrosis	NN
cord-006702-ekf6mja9	170	16	,	,	,
cord-006702-ekf6mja9	170	17	capillary	capillary	JJ
cord-006702-ekf6mja9	170	18	angiogenesis	angiogenesis	NN
cord-006702-ekf6mja9	170	19	and	and	CC
cord-006702-ekf6mja9	170	20	vascular	vascular	JJ
cord-006702-ekf6mja9	170	21	sclerosis	sclerosis	NN
cord-006702-ekf6mja9	170	22	.	.	.
cord-006702-ekf6mja9	171	1	After	after	IN
cord-006702-ekf6mja9	171	2	biopsy	biopsy	NN
cord-006702-ekf6mja9	171	3	,	,	,
cord-006702-ekf6mja9	171	4	all	all	PDT
cord-006702-ekf6mja9	171	5	the	the	DT
cord-006702-ekf6mja9	171	6	patients	patient	NNS
cord-006702-ekf6mja9	171	7	in	in	IN
cord-006702-ekf6mja9	171	8	the	the	DT
cord-006702-ekf6mja9	171	9	existing	exist	VBG
cord-006702-ekf6mja9	171	10	symptoms	symptom	NNS
cord-006702-ekf6mja9	171	11	group	group	NN
cord-006702-ekf6mja9	171	12	needed	need	VBD
cord-006702-ekf6mja9	171	13	treatment	treatment	NN
cord-006702-ekf6mja9	171	14	for	for	IN
cord-006702-ekf6mja9	171	15	preserving	preserve	VBG
cord-006702-ekf6mja9	171	16	peritoneum	peritoneum	NN
cord-006702-ekf6mja9	171	17	.	.	.
cord-006702-ekf6mja9	172	1	While	while	IN
cord-006702-ekf6mja9	172	2	in	in	IN
cord-006702-ekf6mja9	172	3	the	the	DT
cord-006702-ekf6mja9	172	4	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	172	5	group	group	NN
cord-006702-ekf6mja9	172	6	,	,	,
cord-006702-ekf6mja9	172	7	33/44	33/44	CD
cord-006702-ekf6mja9	172	8	(	(	-LRB-
cord-006702-ekf6mja9	172	9	75	75	CD
cord-006702-ekf6mja9	172	10	%	%	NN
cord-006702-ekf6mja9	172	11	)	)	-RRB-
cord-006702-ekf6mja9	172	12	required	require	VBN
cord-006702-ekf6mja9	172	13	treatment	treatment	NN
cord-006702-ekf6mja9	172	14	,	,	,
cord-006702-ekf6mja9	172	15	but	but	CC
cord-006702-ekf6mja9	172	16	11/44	11/44	CD
cord-006702-ekf6mja9	172	17	(	(	-LRB-
cord-006702-ekf6mja9	172	18	25	25	CD
cord-006702-ekf6mja9	172	19	%	%	NN
cord-006702-ekf6mja9	172	20	)	)	-RRB-
cord-006702-ekf6mja9	172	21	were	be	VBD
cord-006702-ekf6mja9	172	22	able	able	JJ
cord-006702-ekf6mja9	172	23	to	to	TO
cord-006702-ekf6mja9	172	24	see	see	VB
cord-006702-ekf6mja9	172	25	the	the	DT
cord-006702-ekf6mja9	172	26	progress	progress	NN
cord-006702-ekf6mja9	172	27	without	without	IN
cord-006702-ekf6mja9	172	28	treatment	treatment	NN
cord-006702-ekf6mja9	172	29	.	.	.
cord-006702-ekf6mja9	173	1	The	the	DT
cord-006702-ekf6mja9	173	2	biopsy	biopsy	NN
cord-006702-ekf6mja9	173	3	results	result	NNS
cord-006702-ekf6mja9	173	4	of	of	IN
cord-006702-ekf6mja9	173	5	the	the	DT
cord-006702-ekf6mja9	173	6	patients	patient	NNS
cord-006702-ekf6mja9	173	7	without	without	IN
cord-006702-ekf6mja9	173	8	treatment	treatment	NN
cord-006702-ekf6mja9	173	9	in	in	IN
cord-006702-ekf6mja9	173	10	the	the	DT
cord-006702-ekf6mja9	173	11	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	173	12	group	group	NN
cord-006702-ekf6mja9	173	13	were	be	VBD
cord-006702-ekf6mja9	173	14	significantly	significantly	RB
cord-006702-ekf6mja9	173	15	fewer	few	JJR
cord-006702-ekf6mja9	173	16	instances	instance	NNS
cord-006702-ekf6mja9	173	17	of	of	IN
cord-006702-ekf6mja9	173	18	mesothelial	mesothelial	JJ
cord-006702-ekf6mja9	173	19	denudation	denudation	NN
cord-006702-ekf6mja9	173	20	and	and	CC
cord-006702-ekf6mja9	173	21	vascular	vascular	JJ
cord-006702-ekf6mja9	173	22	sclerosis	sclerosis	NN
cord-006702-ekf6mja9	173	23	than	than	IN
cord-006702-ekf6mja9	173	24	those	those	DT
cord-006702-ekf6mja9	173	25	of	of	IN
cord-006702-ekf6mja9	173	26	the	the	DT
cord-006702-ekf6mja9	173	27	patients	patient	NNS
cord-006702-ekf6mja9	173	28	required	require	VBN
cord-006702-ekf6mja9	173	29	treatment	treatment	NN
cord-006702-ekf6mja9	173	30	(	(	-LRB-
cord-006702-ekf6mja9	173	31	P<0.01	P<0.01	NNP
cord-006702-ekf6mja9	173	32	)	)	-RRB-
cord-006702-ekf6mja9	173	33	.	.	.
cord-006702-ekf6mja9	174	1	There	there	EX
cord-006702-ekf6mja9	174	2	were	be	VBD
cord-006702-ekf6mja9	174	3	two	two	CD
cord-006702-ekf6mja9	174	4	cases	case	NNS
cord-006702-ekf6mja9	174	5	of	of	IN
cord-006702-ekf6mja9	174	6	peritonitis	peritonitis	NN
cord-006702-ekf6mja9	174	7	after	after	IN
cord-006702-ekf6mja9	174	8	biopsy	biopsy	NN
cord-006702-ekf6mja9	174	9	as	as	IN
cord-006702-ekf6mja9	174	10	complications	complication	NNS
cord-006702-ekf6mja9	174	11	.	.	.
cord-006702-ekf6mja9	175	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	175	2	:	:	:
cord-006702-ekf6mja9	176	1	The	the	DT
cord-006702-ekf6mja9	176	2	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	176	3	biopsy	biopsy	NN
cord-006702-ekf6mja9	176	4	is	be	VBZ
cord-006702-ekf6mja9	176	5	useful	useful	JJ
cord-006702-ekf6mja9	176	6	for	for	IN
cord-006702-ekf6mja9	176	7	deciding	decide	VBG
cord-006702-ekf6mja9	176	8	treatment	treatment	NN
cord-006702-ekf6mja9	176	9	intervention	intervention	NN
cord-006702-ekf6mja9	176	10	for	for	IN
cord-006702-ekf6mja9	176	11	those	those	DT
cord-006702-ekf6mja9	176	12	who	who	WP
cord-006702-ekf6mja9	176	13	have	have	VBP
cord-006702-ekf6mja9	176	14	no	no	DT
cord-006702-ekf6mja9	176	15	EPS	eps	NN
cord-006702-ekf6mja9	176	16	symptoms	symptom	NNS
cord-006702-ekf6mja9	176	17	.	.	.
cord-006702-ekf6mja9	177	1	The	the	DT
cord-006702-ekf6mja9	177	2	PD	PD	NNP
cord-006702-ekf6mja9	177	3	Membrane	Membrane	NNP
cord-006702-ekf6mja9	177	4	Microvasculature	Microvasculature	NNP
cord-006702-ekf6mja9	177	5	in	in	IN
cord-006702-ekf6mja9	177	6	Uremia	Uremia	NNP
cord-006702-ekf6mja9	177	7	and	and	CC
cord-006702-ekf6mja9	177	8	PD	PD	NNP
cord-006702-ekf6mja9	178	1	-Recent	-recent	NN
cord-006702-ekf6mja9	179	1	Findings	finding	NNS
cord-006702-ekf6mja9	179	2	from	from	IN
cord-006702-ekf6mja9	179	3	the	the	DT
cord-006702-ekf6mja9	179	4	International	International	NNP
cord-006702-ekf6mja9	179	5	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	179	6	PD	PD	NNP
cord-006702-ekf6mja9	179	7	Biobank	Biobank	NNP
cord-006702-ekf6mja9	179	8	B.	B.	NNP
cord-006702-ekf6mja9	179	9	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	179	10	(	(	-LRB-
cord-006702-ekf6mja9	179	11	1	1	CD
cord-006702-ekf6mja9	179	12	)	)	-RRB-
cord-006702-ekf6mja9	179	13	,	,	,
cord-006702-ekf6mja9	179	14	M.	M.	NNP
cord-006702-ekf6mja9	179	15	Bartosova	Bartosova	NNP
cord-006702-ekf6mja9	179	16	(	(	-LRB-
cord-006702-ekf6mja9	179	17	1	1	CD
cord-006702-ekf6mja9	179	18	)	)	-RRB-
cord-006702-ekf6mja9	179	19	,	,	.
cord-006702-ekf6mja9	180	1	C.	C.	NNP
cord-006702-ekf6mja9	180	2	Taylan	Taylan	NNP
cord-006702-ekf6mja9	180	3	(	(	-LRB-
cord-006702-ekf6mja9	180	4	2	2	CD
cord-006702-ekf6mja9	180	5	)	)	-RRB-
cord-006702-ekf6mja9	180	6	,	,	,
cord-006702-ekf6mja9	180	7	J.	J.	NNP
cord-006702-ekf6mja9	180	8	Vande	Vande	NNP
cord-006702-ekf6mja9	180	9	Walle	Walle	NNP
cord-006702-ekf6mja9	180	10	(	(	-LRB-
cord-006702-ekf6mja9	180	11	3	3	CD
cord-006702-ekf6mja9	180	12	)	)	-RRB-
cord-006702-ekf6mja9	180	13	,	,	,
cord-006702-ekf6mja9	180	14	U.	U.	NNP
cord-006702-ekf6mja9	180	15	Querfeld	Querfeld	NNP
cord-006702-ekf6mja9	180	16	(	(	-LRB-
cord-006702-ekf6mja9	180	17	4	4	CD
cord-006702-ekf6mja9	180	18	)	)	-RRB-
cord-006702-ekf6mja9	180	19	,	,	,
cord-006702-ekf6mja9	180	20	R.	R.	NNP
cord-006702-ekf6mja9	180	21	Krmar	Krmar	NNP
cord-006702-ekf6mja9	180	22	(	(	-LRB-
cord-006702-ekf6mja9	180	23	5	5	CD
cord-006702-ekf6mja9	180	24	)	)	-RRB-
cord-006702-ekf6mja9	180	25	,	,	.
cord-006702-ekf6mja9	181	1	B.A.	B.A.	NNP
cord-006702-ekf6mja9	181	2	Warady	Warady	NNP
cord-006702-ekf6mja9	181	3	(	(	-LRB-
cord-006702-ekf6mja9	181	4	6	6	CD
cord-006702-ekf6mja9	181	5	)	)	-RRB-
cord-006702-ekf6mja9	181	6	,	,	,
cord-006702-ekf6mja9	181	7	C.P.	C.P.	NNP
cord-006702-ekf6mja9	181	8	Schmitt	Schmitt	NNP
cord-006702-ekf6mja9	181	9	(	(	-LRB-
cord-006702-ekf6mja9	181	10	1	1	CD
cord-006702-ekf6mja9	181	11	Results	result	NNS
cord-006702-ekf6mja9	181	12	:	:	:
cord-006702-ekf6mja9	182	1	The	the	DT
cord-006702-ekf6mja9	182	2	parietal	parietal	JJ
cord-006702-ekf6mja9	182	3	peritoneum	peritoneum	NN
cord-006702-ekf6mja9	182	4	exhibits	exhibit	VBZ
cord-006702-ekf6mja9	182	5	marked	mark	VBN
cord-006702-ekf6mja9	182	6	age	age	NN
cord-006702-ekf6mja9	182	7	dependent	dependent	JJ
cord-006702-ekf6mja9	182	8	differences	difference	NNS
cord-006702-ekf6mja9	182	9	in	in	IN
cord-006702-ekf6mja9	182	10	vascular	vascular	JJ
cord-006702-ekf6mja9	182	11	density	density	NN
cord-006702-ekf6mja9	182	12	,	,	,
cord-006702-ekf6mja9	182	13	with	with	IN
cord-006702-ekf6mja9	182	14	highest	high	JJS
cord-006702-ekf6mja9	182	15	blood	blood	NN
cord-006702-ekf6mja9	182	16	capillary	capillary	JJ
cord-006702-ekf6mja9	182	17	density	density	NN
cord-006702-ekf6mja9	182	18	and	and	CC
cord-006702-ekf6mja9	182	19	endothelial	endothelial	JJ
cord-006702-ekf6mja9	182	20	exchange	exchange	NN
cord-006702-ekf6mja9	182	21	area	area	NN
cord-006702-ekf6mja9	182	22	in	in	IN
cord-006702-ekf6mja9	182	23	infancy	infancy	NN
cord-006702-ekf6mja9	182	24	and	and	CC
cord-006702-ekf6mja9	182	25	lowest	low	JJS
cord-006702-ekf6mja9	182	26	values	value	NNS
cord-006702-ekf6mja9	182	27	in	in	IN
cord-006702-ekf6mja9	182	28	children	child	NNS
cord-006702-ekf6mja9	182	29	aged	age	VBN
cord-006702-ekf6mja9	182	30	7	7	CD
cord-006702-ekf6mja9	182	31	-	-	SYM
cord-006702-ekf6mja9	182	32	12	12	CD
cord-006702-ekf6mja9	182	33	yrs	yr	NNS
cord-006702-ekf6mja9	182	34	.	.	.
cord-006702-ekf6mja9	183	1	Lymphatic	lymphatic	JJ
cord-006702-ekf6mja9	183	2	vessel	vessel	NN
cord-006702-ekf6mja9	183	3	density	density	NN
cord-006702-ekf6mja9	183	4	is	be	VBZ
cord-006702-ekf6mja9	183	5	markedly	markedly	RB
cord-006702-ekf6mja9	183	6	lower	low	JJR
cord-006702-ekf6mja9	183	7	,	,	,
cord-006702-ekf6mja9	183	8	but	but	CC
cord-006702-ekf6mja9	183	9	again	again	RB
cord-006702-ekf6mja9	183	10	70	70	CD
cord-006702-ekf6mja9	183	11	%	%	NN
cord-006702-ekf6mja9	183	12	higher	high	JJR
cord-006702-ekf6mja9	183	13	in	in	IN
cord-006702-ekf6mja9	183	14	infants	infant	NNS
cord-006702-ekf6mja9	183	15	.	.	.
cord-006702-ekf6mja9	184	1	Omental	omental	JJ
cord-006702-ekf6mja9	184	2	blood	blood	NN
cord-006702-ekf6mja9	184	3	capillary	capillary	JJ
cord-006702-ekf6mja9	184	4	density	density	NN
cord-006702-ekf6mja9	184	5	correlates	correlate	VBZ
cord-006702-ekf6mja9	184	6	with	with	IN
cord-006702-ekf6mja9	184	7	parietal	parietal	JJ
cord-006702-ekf6mja9	184	8	capillary	capillary	JJ
cord-006702-ekf6mja9	184	9	density	density	NN
cord-006702-ekf6mja9	184	10	(	(	-LRB-
cord-006702-ekf6mja9	184	11	r	r	NN
cord-006702-ekf6mja9	184	12	=	=	NN
cord-006702-ekf6mja9	184	13	0.391	0.391	CD
cord-006702-ekf6mja9	184	14	;	;	:
cord-006702-ekf6mja9	184	15	p	p	NN
cord-006702-ekf6mja9	184	16	=	=	SYM
cord-006702-ekf6mja9	184	17	0.03	0.03	CD
cord-006702-ekf6mja9	184	18	)	)	-RRB-
cord-006702-ekf6mja9	184	19	,	,	,
cord-006702-ekf6mja9	184	20	small	small	JJ
cord-006702-ekf6mja9	184	21	lymphatic	lymphatic	JJ
cord-006702-ekf6mja9	184	22	vessels	vessel	NNS
cord-006702-ekf6mja9	184	23	are	be	VBP
cord-006702-ekf6mja9	184	24	few	few	JJ
cord-006702-ekf6mja9	184	25	.	.	.
cord-006702-ekf6mja9	185	1	Uremia	Uremia	NNP
cord-006702-ekf6mja9	185	2	reduces	reduce	VBZ
cord-006702-ekf6mja9	185	3	omental	omental	RB
cord-006702-ekf6mja9	185	4	but	but	CC
cord-006702-ekf6mja9	185	5	not	not	RB
cord-006702-ekf6mja9	185	6	parietal	parietal	JJ
cord-006702-ekf6mja9	185	7	blood	blood	NN
cord-006702-ekf6mja9	185	8	vessel	vessel	NN
cord-006702-ekf6mja9	185	9	density	density	NN
cord-006702-ekf6mja9	185	10	by	by	IN
cord-006702-ekf6mja9	185	11	51	51	CD
cord-006702-ekf6mja9	185	12	%	%	NN
cord-006702-ekf6mja9	185	13	,	,	,
cord-006702-ekf6mja9	185	14	Angp-2	angp-2	JJ
cord-006702-ekf6mja9	185	15	levels	level	NNS
cord-006702-ekf6mja9	185	16	are	be	VBP
cord-006702-ekf6mja9	185	17	78	78	CD
cord-006702-ekf6mja9	185	18	%	%	NN
cord-006702-ekf6mja9	185	19	lower	low	JJR
cord-006702-ekf6mja9	185	20	.	.	.
cord-006702-ekf6mja9	186	1	The	the	DT
cord-006702-ekf6mja9	186	2	submesothelial	submesothelial	JJ
cord-006702-ekf6mja9	186	3	3	3	CD
cord-006702-ekf6mja9	186	4	vessel	vessel	NN
cord-006702-ekf6mja9	186	5	layer	layer	NN
cord-006702-ekf6mja9	186	6	structure	structure	NN
cord-006702-ekf6mja9	186	7	dissipates	dissipate	VBZ
cord-006702-ekf6mja9	186	8	with	with	IN
cord-006702-ekf6mja9	186	9	low	low	JJ
cord-006702-ekf6mja9	186	10	GDP	GDP	NNP
cord-006702-ekf6mja9	186	11	PD	PD	NNP
cord-006702-ekf6mja9	186	12	,	,	,
cord-006702-ekf6mja9	186	13	blood	blood	NN
cord-006702-ekf6mja9	186	14	vessel	vessel	NN
cord-006702-ekf6mja9	186	15	density	density	NN
cord-006702-ekf6mja9	186	16	increases	increase	VBZ
cord-006702-ekf6mja9	186	17	2	2	CD
cord-006702-ekf6mja9	186	18	-	-	SYM
cord-006702-ekf6mja9	186	19	3	3	CD
cord-006702-ekf6mja9	186	20	fold	fold	NN
cord-006702-ekf6mja9	186	21	,	,	,
cord-006702-ekf6mja9	186	22	as	as	IN
cord-006702-ekf6mja9	186	23	do	do	VBP
cord-006702-ekf6mja9	186	24	TGF	TGF	NNP
cord-006702-ekf6mja9	186	25	-	-	HYPH
cord-006702-ekf6mja9	186	26	ß	ß	NN
cord-006702-ekf6mja9	186	27	/	/	SYM
cord-006702-ekf6mja9	186	28	pSMAD	psmad	RB
cord-006702-ekf6mja9	186	29	,	,	,
cord-006702-ekf6mja9	186	30	VEGF	VEGF	NNP
cord-006702-ekf6mja9	186	31	,	,	,
cord-006702-ekf6mja9	186	32	activated	activate	VBN
cord-006702-ekf6mja9	186	33	fibroblast	fibroblast	NN
cord-006702-ekf6mja9	186	34	and	and	CC
cord-006702-ekf6mja9	186	35	CD45	CD45	NNP
cord-006702-ekf6mja9	186	36	/	/	SYM
cord-006702-ekf6mja9	186	37	CD68	cd68	NN
cord-006702-ekf6mja9	186	38	+	+	CC
cord-006702-ekf6mja9	186	39	macrophage	macrophage	NN
cord-006702-ekf6mja9	186	40	abundance	abundance	NN
cord-006702-ekf6mja9	186	41	.	.	.
cord-006702-ekf6mja9	187	1	Mild	mild	JJ
cord-006702-ekf6mja9	187	2	lumen	lumen	NN
cord-006702-ekf6mja9	187	3	narrowing	narrowing	NN
cord-006702-ekf6mja9	187	4	develops	develop	VBZ
cord-006702-ekf6mja9	187	5	in	in	IN
cord-006702-ekf6mja9	187	6	31	31	CD
cord-006702-ekf6mja9	187	7	%	%	NN
cord-006702-ekf6mja9	187	8	of	of	IN
cord-006702-ekf6mja9	187	9	blood	blood	NN
cord-006702-ekf6mja9	187	10	vessels	vessel	NNS
cord-006702-ekf6mja9	187	11	,	,	,
cord-006702-ekf6mja9	187	12	lymphatic	lymphatic	JJ
cord-006702-ekf6mja9	187	13	vessel	vessel	NN
cord-006702-ekf6mja9	187	14	density	density	NN
cord-006702-ekf6mja9	187	15	remains	remain	VBZ
cord-006702-ekf6mja9	187	16	low	low	JJ
cord-006702-ekf6mja9	187	17	.	.	.
cord-006702-ekf6mja9	188	1	EMT	EMT	NNP
cord-006702-ekf6mja9	188	2	and	and	CC
cord-006702-ekf6mja9	188	3	profibrotic	profibrotic	JJ
cord-006702-ekf6mja9	188	4	CD90	CD90	NNP
cord-006702-ekf6mja9	188	5	+	+	CC
cord-006702-ekf6mja9	188	6	fibroblast	fibroblast	NN
cord-006702-ekf6mja9	188	7	subpopulations	subpopulation	NNS
cord-006702-ekf6mja9	188	8	appear	appear	VBP
cord-006702-ekf6mja9	188	9	more	more	RBR
cord-006702-ekf6mja9	188	10	prevalent	prevalent	JJ
cord-006702-ekf6mja9	188	11	with	with	IN
cord-006702-ekf6mja9	188	12	high	high	JJ
cord-006702-ekf6mja9	188	13	GDP	GDP	NNP
cord-006702-ekf6mja9	188	14	PD	PD	NNP
cord-006702-ekf6mja9	188	15	-	-	HYPH
cord-006702-ekf6mja9	188	16	fluids	fluid	NNS
cord-006702-ekf6mja9	188	17	.	.	.
cord-006702-ekf6mja9	189	1	D	D	NNP
cord-006702-ekf6mja9	189	2	/	/	SYM
cord-006702-ekf6mja9	189	3	P	p	NN
cord-006702-ekf6mja9	189	4	creatinine	creatinine	NN
cord-006702-ekf6mja9	189	5	ratios	ratio	NNS
cord-006702-ekf6mja9	189	6	correlate	correlate	VBP
cord-006702-ekf6mja9	189	7	with	with	IN
cord-006702-ekf6mja9	189	8	parietal	parietal	JJ
cord-006702-ekf6mja9	189	9	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	189	10	vessel	vessel	NN
cord-006702-ekf6mja9	189	11	density	density	NN
cord-006702-ekf6mja9	189	12	at	at	IN
cord-006702-ekf6mja9	189	13	baseline	baseline	NN
cord-006702-ekf6mja9	190	1	(	(	-LRB-
cord-006702-ekf6mja9	190	2	r=0.49	r=0.49	NN
cord-006702-ekf6mja9	190	3	,	,	,
cord-006702-ekf6mja9	190	4	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	190	5	)	)	-RRB-
cord-006702-ekf6mja9	190	6	,	,	,
cord-006702-ekf6mja9	190	7	and	and	CC
cord-006702-ekf6mja9	190	8	while	while	IN
cord-006702-ekf6mja9	190	9	on	on	IN
cord-006702-ekf6mja9	190	10	PD	PD	NNP
cord-006702-ekf6mja9	190	11	(	(	-LRB-
cord-006702-ekf6mja9	190	12	r=0.57	r=0.57	NNP
cord-006702-ekf6mja9	190	13	,	,	,
cord-006702-ekf6mja9	190	14	p=0.08	p=0.08	NNP
cord-006702-ekf6mja9	190	15	)	)	-RRB-
cord-006702-ekf6mja9	190	16	but	but	CC
cord-006702-ekf6mja9	190	17	not	not	RB
cord-006702-ekf6mja9	190	18	with	with	IN
cord-006702-ekf6mja9	190	19	submesothelial	submesothelial	JJ
cord-006702-ekf6mja9	190	20	thickness	thickness	NN
cord-006702-ekf6mja9	190	21	.	.	.
cord-006702-ekf6mja9	191	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	191	2	:	:	:
cord-006702-ekf6mja9	192	1	Peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	192	2	vessel	vessel	NN
cord-006702-ekf6mja9	192	3	density	density	NN
cord-006702-ekf6mja9	192	4	defines	define	VBZ
cord-006702-ekf6mja9	192	5	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	192	6	membrane	membrane	NN
cord-006702-ekf6mja9	192	7	transport	transport	NN
cord-006702-ekf6mja9	192	8	function	function	NN
cord-006702-ekf6mja9	192	9	.	.	.
cord-006702-ekf6mja9	193	1	Despite	despite	IN
cord-006702-ekf6mja9	193	2	low	low	JJ
cord-006702-ekf6mja9	193	3	GDP	gdp	NN
cord-006702-ekf6mja9	193	4	fluid	fluid	NN
cord-006702-ekf6mja9	193	5	usage	usage	NN
cord-006702-ekf6mja9	193	6	,	,	,
cord-006702-ekf6mja9	193	7	progressive	progressive	JJ
cord-006702-ekf6mja9	193	8	blood	blood	NN
cord-006702-ekf6mja9	193	9	capillarisation	capillarisation	NN
cord-006702-ekf6mja9	193	10	develops	develop	VBZ
cord-006702-ekf6mja9	193	11	with	with	IN
cord-006702-ekf6mja9	193	12	time	time	NN
cord-006702-ekf6mja9	193	13	on	on	IN
cord-006702-ekf6mja9	193	14	PD	PD	NNP
cord-006702-ekf6mja9	193	15	,	,	,
cord-006702-ekf6mja9	193	16	while	while	IN
cord-006702-ekf6mja9	193	17	lymphatic	lymphatic	JJ
cord-006702-ekf6mja9	193	18	vessel	vessel	NN
cord-006702-ekf6mja9	193	19	density	density	NN
cord-006702-ekf6mja9	193	20	remains	remain	VBZ
cord-006702-ekf6mja9	193	21	low	low	JJ
cord-006702-ekf6mja9	193	22	.	.	.
cord-006702-ekf6mja9	194	1	FP	FP	NNP
cord-006702-ekf6mja9	194	2	-	-	HYPH
cord-006702-ekf6mja9	194	3	S08	S08	NNP
cord-006702-ekf6mja9	194	4	-	-	HYPH
cord-006702-ekf6mja9	194	5	1	1	CD
cord-006702-ekf6mja9	194	6	PKHD1	PKHD1	NNS
cord-006702-ekf6mja9	194	7	mutation	mutation	NN
cord-006702-ekf6mja9	194	8	in	in	IN
cord-006702-ekf6mja9	194	9	autosomal	autosomal	JJ
cord-006702-ekf6mja9	194	10	recessive	recessive	JJ
cord-006702-ekf6mja9	194	11	polycystic	polycystic	JJ
cord-006702-ekf6mja9	194	12	kidney	kidney	NN
cord-006702-ekf6mja9	194	13	disease	disease	NN
cord-006702-ekf6mja9	194	14	(	(	-LRB-
cord-006702-ekf6mja9	194	15	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	194	16	)	)	-RRB-
cord-006702-ekf6mja9	194	17	:	:	:
cord-006702-ekf6mja9	194	18	genotype	genotype	NN
cord-006702-ekf6mja9	194	19	-	-	HYPH
cord-006702-ekf6mja9	194	20	phenotype	phenotype	NN
cord-006702-ekf6mja9	194	21	correlations	correlation	NNS
cord-006702-ekf6mja9	194	22	from	from	IN
cord-006702-ekf6mja9	194	23	a	a	DT
cord-006702-ekf6mja9	194	24	series	series	NN
cord-006702-ekf6mja9	194	25	of	of	IN
cord-006702-ekf6mja9	194	26	308	308	CD
cord-006702-ekf6mja9	194	27	cases	case	NNS
cord-006702-ekf6mja9	194	28	S.	S.	NNP
cord-006702-ekf6mja9	194	29	Hamo	Hamo	NNP
cord-006702-ekf6mja9	194	30	(	(	-LRB-
cord-006702-ekf6mja9	194	31	1	1	CD
cord-006702-ekf6mja9	194	32	)	)	-RRB-
cord-006702-ekf6mja9	194	33	,	,	,
cord-006702-ekf6mja9	194	34	J.	J.	NNP
cord-006702-ekf6mja9	194	35	Bacchetta	Bacchetta	NNP
cord-006702-ekf6mja9	194	36	(	(	-LRB-
cord-006702-ekf6mja9	194	37	2	2	CD
cord-006702-ekf6mja9	194	38	)	)	-RRB-
cord-006702-ekf6mja9	194	39	,	,	,
cord-006702-ekf6mja9	194	40	A.	A.	NNP
cord-006702-ekf6mja9	194	41	Bertholet	Bertholet	NNP
cord-006702-ekf6mja9	194	42	-	-	HYPH
cord-006702-ekf6mja9	194	43	Thomas	Thomas	NNP
cord-006702-ekf6mja9	194	44	(	(	-LRB-
cord-006702-ekf6mja9	194	45	2	2	CD
cord-006702-ekf6mja9	194	46	)	)	-RRB-
cord-006702-ekf6mja9	194	47	,	,	,
cord-006702-ekf6mja9	194	48	P.	P.	NNP
cord-006702-ekf6mja9	194	49	Cochat	Cochat	NNP
cord-006702-ekf6mja9	194	50	(	(	-LRB-
cord-006702-ekf6mja9	194	51	2	2	CD
cord-006702-ekf6mja9	194	52	)	)	-RRB-
cord-006702-ekf6mja9	194	53	,	,	,
cord-006702-ekf6mja9	194	54	L.	L.	NNP
cord-006702-ekf6mja9	194	55	Calemard	Calemard	NNP
cord-006702-ekf6mja9	194	56	(	(	-LRB-
cord-006702-ekf6mja9	194	57	3	3	CD
cord-006702-ekf6mja9	194	58	Objectives	objectives	NN
cord-006702-ekf6mja9	194	59	:	:	:
cord-006702-ekf6mja9	195	1	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	195	2	is	be	VBZ
cord-006702-ekf6mja9	195	3	a	a	DT
cord-006702-ekf6mja9	195	4	recessive	recessive	JJ
cord-006702-ekf6mja9	195	5	orphan	orphan	NN
cord-006702-ekf6mja9	195	6	disease	disease	NN
cord-006702-ekf6mja9	195	7	due	due	IN
cord-006702-ekf6mja9	195	8	to	to	IN
cord-006702-ekf6mja9	195	9	PKHD1	PKHD1	NNS
cord-006702-ekf6mja9	195	10	mutations	mutation	NNS
cord-006702-ekf6mja9	195	11	.	.	.
cord-006702-ekf6mja9	196	1	The	the	DT
cord-006702-ekf6mja9	196	2	main	main	JJ
cord-006702-ekf6mja9	196	3	objective	objective	NN
cord-006702-ekf6mja9	196	4	of	of	IN
cord-006702-ekf6mja9	196	5	our	-PRON-	PRP$
cord-006702-ekf6mja9	196	6	study	study	NN
cord-006702-ekf6mja9	196	7	was	be	VBD
cord-006702-ekf6mja9	196	8	to	to	TO
cord-006702-ekf6mja9	196	9	characterize	characterize	VB
cord-006702-ekf6mja9	196	10	the	the	DT
cord-006702-ekf6mja9	196	11	phenotypic	phenotypic	JJ
cord-006702-ekf6mja9	196	12	variability	variability	NN
cord-006702-ekf6mja9	196	13	of	of	IN
cord-006702-ekf6mja9	196	14	patients	patient	NNS
cord-006702-ekf6mja9	196	15	with	with	IN
cord-006702-ekf6mja9	196	16	PKHD1	PKHD1	NNS
cord-006702-ekf6mja9	196	17	mutations	mutation	NNS
cord-006702-ekf6mja9	196	18	,	,	,
cord-006702-ekf6mja9	196	19	according	accord	VBG
cord-006702-ekf6mja9	196	20	to	to	IN
cord-006702-ekf6mja9	196	21	the	the	DT
cord-006702-ekf6mja9	196	22	different	different	JJ
cord-006702-ekf6mja9	196	23	types	type	NNS
cord-006702-ekf6mja9	196	24	of	of	IN
cord-006702-ekf6mja9	196	25	mutations	mutation	NNS
cord-006702-ekf6mja9	196	26	.	.	.
cord-006702-ekf6mja9	197	1	Methods	method	NNS
cord-006702-ekf6mja9	197	2	:	:	:
cord-006702-ekf6mja9	197	3	This	this	DT
cord-006702-ekf6mja9	197	4	study	study	NN
cord-006702-ekf6mja9	197	5	was	be	VBD
cord-006702-ekf6mja9	197	6	performed	perform	VBN
cord-006702-ekf6mja9	197	7	in	in	IN
cord-006702-ekf6mja9	197	8	a	a	DT
cord-006702-ekf6mja9	197	9	cohort	cohort	NN
cord-006702-ekf6mja9	197	10	of	of	IN
cord-006702-ekf6mja9	197	11	308	308	CD
cord-006702-ekf6mja9	197	12	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	197	13	patients	patient	NNS
cord-006702-ekf6mja9	197	14	with	with	IN
cord-006702-ekf6mja9	197	15	a	a	DT
cord-006702-ekf6mja9	197	16	genetic	genetic	JJ
cord-006702-ekf6mja9	197	17	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	197	18	made	make	VBN
cord-006702-ekf6mja9	197	19	in	in	IN
cord-006702-ekf6mja9	197	20	our	-PRON-	PRP$
cord-006702-ekf6mja9	197	21	genetic	genetic	JJ
cord-006702-ekf6mja9	197	22	centre	centre	NN
cord-006702-ekf6mja9	197	23	.	.	.
cord-006702-ekf6mja9	198	1	We	-PRON-	PRP
cord-006702-ekf6mja9	198	2	asked	ask	VBD
cord-006702-ekf6mja9	198	3	prescribing	prescribe	VBG
cord-006702-ekf6mja9	198	4	physicians	physician	NNS
cord-006702-ekf6mja9	198	5	to	to	TO
cord-006702-ekf6mja9	198	6	provide	provide	VB
cord-006702-ekf6mja9	198	7	minimal	minimal	JJ
cord-006702-ekf6mja9	198	8	clinical	clinical	JJ
cord-006702-ekf6mja9	198	9	data	datum	NNS
cord-006702-ekf6mja9	198	10	,	,	,
cord-006702-ekf6mja9	198	11	and	and	CC
cord-006702-ekf6mja9	198	12	sent	send	VBD
cord-006702-ekf6mja9	198	13	them	-PRON-	PRP
cord-006702-ekf6mja9	198	14	a	a	DT
cord-006702-ekf6mja9	198	15	questionnaire	questionnaire	NN
cord-006702-ekf6mja9	198	16	to	to	TO
cord-006702-ekf6mja9	198	17	retrospectively	retrospectively	RB
cord-006702-ekf6mja9	198	18	update	update	VB
cord-006702-ekf6mja9	198	19	the	the	DT
cord-006702-ekf6mja9	198	20	main	main	JJ
cord-006702-ekf6mja9	198	21	outcomes	outcome	NNS
cord-006702-ekf6mja9	198	22	.	.	.
cord-006702-ekf6mja9	199	1	Results	result	NNS
cord-006702-ekf6mja9	199	2	:	:	:
cord-006702-ekf6mja9	200	1	Patients	patient	NNS
cord-006702-ekf6mja9	200	2	were	be	VBD
cord-006702-ekf6mja9	200	3	divided	divide	VBN
cord-006702-ekf6mja9	200	4	into	into	IN
cord-006702-ekf6mja9	200	5	three	three	CD
cord-006702-ekf6mja9	200	6	genotypic	genotypic	JJ
cord-006702-ekf6mja9	200	7	groups	group	NNS
cord-006702-ekf6mja9	200	8	:	:	:
cord-006702-ekf6mja9	200	9	the	the	DT
cord-006702-ekf6mja9	200	10	first	first	JJ
cord-006702-ekf6mja9	200	11	group	group	NN
cord-006702-ekf6mja9	200	12	(	(	-LRB-
cord-006702-ekf6mja9	200	13	G1,N=65	G1,N=65	NNP
cord-006702-ekf6mja9	200	14	)	)	-RRB-
cord-006702-ekf6mja9	200	15	consisted	consist	VBD
cord-006702-ekf6mja9	200	16	of	of	IN
cord-006702-ekf6mja9	200	17	patients	patient	NNS
cord-006702-ekf6mja9	200	18	with	with	IN
cord-006702-ekf6mja9	200	19	two	two	CD
cord-006702-ekf6mja9	200	20	truncating	truncate	VBG
cord-006702-ekf6mja9	200	21	mutations	mutation	NNS
cord-006702-ekf6mja9	200	22	,	,	,
cord-006702-ekf6mja9	200	23	the	the	DT
cord-006702-ekf6mja9	200	24	second	second	JJ
cord-006702-ekf6mja9	200	25	group	group	NN
cord-006702-ekf6mja9	200	26	(	(	-LRB-
cord-006702-ekf6mja9	200	27	G2	G2	NNP
cord-006702-ekf6mja9	200	28	,	,	,
cord-006702-ekf6mja9	200	29	N=117	n=117	NN
cord-006702-ekf6mja9	200	30	)	)	-RRB-
cord-006702-ekf6mja9	200	31	of	of	IN
cord-006702-ekf6mja9	200	32	patients	patient	NNS
cord-006702-ekf6mja9	200	33	with	with	IN
cord-006702-ekf6mja9	200	34	one	one	CD
cord-006702-ekf6mja9	200	35	truncating	truncating	NN
cord-006702-ekf6mja9	200	36	and	and	CC
cord-006702-ekf6mja9	200	37	one	one	CD
cord-006702-ekf6mja9	200	38	non	non	JJ
cord-006702-ekf6mja9	200	39	-	-	JJ
cord-006702-ekf6mja9	200	40	truncating	truncating	JJ
cord-006702-ekf6mja9	200	41	mutation	mutation	NN
cord-006702-ekf6mja9	200	42	,	,	,
cord-006702-ekf6mja9	200	43	and	and	CC
cord-006702-ekf6mja9	200	44	the	the	DT
cord-006702-ekf6mja9	200	45	third	third	JJ
cord-006702-ekf6mja9	200	46	group	group	NN
cord-006702-ekf6mja9	200	47	(	(	-LRB-
cord-006702-ekf6mja9	200	48	G3	G3	NNP
cord-006702-ekf6mja9	200	49	,	,	,
cord-006702-ekf6mja9	200	50	N=126	n=126	NN
cord-006702-ekf6mja9	200	51	)	)	-RRB-
cord-006702-ekf6mja9	200	52	of	of	IN
cord-006702-ekf6mja9	200	53	patients	patient	NNS
cord-006702-ekf6mja9	200	54	with	with	IN
cord-006702-ekf6mja9	200	55	two	two	CD
cord-006702-ekf6mja9	200	56	non	non	JJ
cord-006702-ekf6mja9	200	57	-	-	JJ
cord-006702-ekf6mja9	200	58	truncating	truncating	JJ
cord-006702-ekf6mja9	200	59	mutations	mutation	NNS
cord-006702-ekf6mja9	200	60	.	.	.
cord-006702-ekf6mja9	201	1	The	the	DT
cord-006702-ekf6mja9	201	2	proportion	proportion	NN
cord-006702-ekf6mja9	201	3	of	of	IN
cord-006702-ekf6mja9	201	4	severe	severe	JJ
cord-006702-ekf6mja9	201	5	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	201	6	(	(	-LRB-
cord-006702-ekf6mja9	201	7	e.g.	e.g.	JJ
cord-006702-ekf6mja9	201	8	pregnancy	pregnancy	NN
cord-006702-ekf6mja9	201	9	termination	termination	NN
cord-006702-ekf6mja9	201	10	or	or	CC
cord-006702-ekf6mja9	201	11	neonatal	neonatal	JJ
cord-006702-ekf6mja9	201	12	death	death	NN
cord-006702-ekf6mja9	201	13	)	)	-RRB-
cord-006702-ekf6mja9	201	14	was	be	VBD
cord-006702-ekf6mja9	201	15	significantly	significantly	RB
cord-006702-ekf6mja9	201	16	greater	great	JJR
cord-006702-ekf6mja9	201	17	in	in	IN
cord-006702-ekf6mja9	201	18	G1	G1	NNP
cord-006702-ekf6mja9	201	19	:	:	:
cord-006702-ekf6mja9	201	20	94	94	CD
cord-006702-ekf6mja9	201	21	%	%	NN
cord-006702-ekf6mja9	201	22	in	in	IN
cord-006702-ekf6mja9	201	23	G1	G1	NNP
cord-006702-ekf6mja9	201	24	,	,	,
cord-006702-ekf6mja9	201	25	47	47	CD
cord-006702-ekf6mja9	201	26	%	%	NN
cord-006702-ekf6mja9	201	27	in	in	IN
cord-006702-ekf6mja9	201	28	G2	G2	NNP
cord-006702-ekf6mja9	201	29	and	and	CC
cord-006702-ekf6mja9	201	30	27	27	CD
cord-006702-ekf6mja9	201	31	%	%	NN
cord-006702-ekf6mja9	201	32	in	in	IN
cord-006702-ekf6mja9	201	33	G3	G3	NNP
cord-006702-ekf6mja9	201	34	(	(	-LRB-
cord-006702-ekf6mja9	201	35	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	201	36	)	)	-RRB-
cord-006702-ekf6mja9	201	37	.	.	.
cord-006702-ekf6mja9	202	1	77	77	CD
cord-006702-ekf6mja9	202	2	patients	patient	NNS
cord-006702-ekf6mja9	202	3	suffered	suffer	VBD
cord-006702-ekf6mja9	202	4	from	from	IN
cord-006702-ekf6mja9	202	5	chronic	chronic	JJ
cord-006702-ekf6mja9	202	6	kidney	kidney	NN
cord-006702-ekf6mja9	202	7	disease	disease	NN
cord-006702-ekf6mja9	202	8	(	(	-LRB-
cord-006702-ekf6mja9	202	9	CKD	CKD	NNP
cord-006702-ekf6mja9	202	10	)	)	-RRB-
cord-006702-ekf6mja9	202	11	:	:	:
cord-006702-ekf6mja9	202	12	G1	G1	NNP
cord-006702-ekf6mja9	202	13	N=4	N=4	NNP
cord-006702-ekf6mja9	202	14	,	,	,
cord-006702-ekf6mja9	202	15	G2	G2	NNP
cord-006702-ekf6mja9	202	16	N=28	N=28	NNP
cord-006702-ekf6mja9	202	17	and	and	CC
cord-006702-ekf6mja9	202	18	G3	G3	NNP
cord-006702-ekf6mja9	202	19	N=45	N=45	NNPS
cord-006702-ekf6mja9	202	20	.	.	.
cord-006702-ekf6mja9	203	1	Notably	notably	RB
cord-006702-ekf6mja9	203	2	,	,	,
cord-006702-ekf6mja9	203	3	two	two	CD
cord-006702-ekf6mja9	203	4	patients	patient	NNS
cord-006702-ekf6mja9	203	5	from	from	IN
cord-006702-ekf6mja9	203	6	G3	G3	NNP
cord-006702-ekf6mja9	203	7	developed	develop	VBD
cord-006702-ekf6mja9	203	8	CKD	CKD	NNP
cord-006702-ekf6mja9	203	9	before	before	IN
cord-006702-ekf6mja9	203	10	the	the	DT
cord-006702-ekf6mja9	203	11	age	age	NN
cord-006702-ekf6mja9	203	12	of	of	IN
cord-006702-ekf6mja9	203	13	3	3	CD
cord-006702-ekf6mja9	203	14	months	month	NNS
cord-006702-ekf6mja9	203	15	.	.	.
cord-006702-ekf6mja9	204	1	Renal	renal	JJ
cord-006702-ekf6mja9	204	2	transplantation	transplantation	NN
cord-006702-ekf6mja9	204	3	was	be	VBD
cord-006702-ekf6mja9	204	4	performed	perform	VBN
cord-006702-ekf6mja9	204	5	in	in	IN
cord-006702-ekf6mja9	204	6	13	13	CD
cord-006702-ekf6mja9	204	7	patients	patient	NNS
cord-006702-ekf6mja9	204	8	(	(	-LRB-
cord-006702-ekf6mja9	204	9	G1	G1	NNP
cord-006702-ekf6mja9	204	10	N=0	N=0	NNP
cord-006702-ekf6mja9	204	11	;	;	:
cord-006702-ekf6mja9	204	12	G2	G2	NNP
cord-006702-ekf6mja9	204	13	N=5	N=5	NNP
cord-006702-ekf6mja9	204	14	;	;	:
cord-006702-ekf6mja9	204	15	G3	G3	NNP
cord-006702-ekf6mja9	204	16	N=8	N=8	NNP
cord-006702-ekf6mja9	204	17	)	)	-RRB-
cord-006702-ekf6mja9	204	18	.	.	.
cord-006702-ekf6mja9	205	1	Portal	portal	JJ
cord-006702-ekf6mja9	205	2	hypertension	hypertension	NN
cord-006702-ekf6mja9	205	3	occurred	occur	VBD
cord-006702-ekf6mja9	205	4	in	in	IN
cord-006702-ekf6mja9	205	5	61	61	CD
cord-006702-ekf6mja9	205	6	patients	patient	NNS
cord-006702-ekf6mja9	205	7	at	at	IN
cord-006702-ekf6mja9	205	8	a	a	DT
cord-006702-ekf6mja9	205	9	mean	mean	JJ
cord-006702-ekf6mja9	205	10	age	age	NN
cord-006702-ekf6mja9	205	11	of	of	IN
cord-006702-ekf6mja9	205	12	13.9	13.9	CD
cord-006702-ekf6mja9	205	13	years	year	NNS
cord-006702-ekf6mja9	205	14	;	;	:
cord-006702-ekf6mja9	205	15	oesophageal	oesophageal	JJ
cord-006702-ekf6mja9	205	16	varices	varix	NNS
cord-006702-ekf6mja9	205	17	were	be	VBD
cord-006702-ekf6mja9	205	18	present	present	JJ
cord-006702-ekf6mja9	205	19	in	in	IN
cord-006702-ekf6mja9	205	20	18	18	CD
cord-006702-ekf6mja9	205	21	patients	patient	NNS
cord-006702-ekf6mja9	205	22	and	and	CC
cord-006702-ekf6mja9	205	23	complicated	complicate	VBN
cord-006702-ekf6mja9	205	24	by	by	IN
cord-006702-ekf6mja9	205	25	bleeding	bleed	VBG
cord-006702-ekf6mja9	205	26	in	in	IN
cord-006702-ekf6mja9	205	27	14	14	CD
cord-006702-ekf6mja9	205	28	patients	patient	NNS
cord-006702-ekf6mja9	205	29	(	(	-LRB-
cord-006702-ekf6mja9	205	30	G1	g1	NN
cord-006702-ekf6mja9	205	31	:	:	:
cord-006702-ekf6mja9	205	32	N=0	N=0	NNP
cord-006702-ekf6mja9	205	33	,	,	,
cord-006702-ekf6mja9	205	34	G2	G2	NNP
cord-006702-ekf6mja9	205	35	:	:	:
cord-006702-ekf6mja9	205	36	N=9	N=9	NNP
cord-006702-ekf6mja9	205	37	,	,	,
cord-006702-ekf6mja9	205	38	G3	G3	NNP
cord-006702-ekf6mja9	205	39	:	:	:
cord-006702-ekf6mja9	205	40	N=5	N=5	NNP
cord-006702-ekf6mja9	205	41	)	)	-RRB-
cord-006702-ekf6mja9	205	42	.	.	.
cord-006702-ekf6mja9	206	1	Three	three	CD
cord-006702-ekf6mja9	206	2	patients	patient	NNS
cord-006702-ekf6mja9	206	3	received	receive	VBD
cord-006702-ekf6mja9	206	4	a	a	DT
cord-006702-ekf6mja9	206	5	liver	liver	NN
cord-006702-ekf6mja9	206	6	transplant	transplant	NN
cord-006702-ekf6mja9	206	7	(	(	-LRB-
cord-006702-ekf6mja9	206	8	G2	G2	NNP
cord-006702-ekf6mja9	206	9	N=2	N=2	NNP
cord-006702-ekf6mja9	206	10	,	,	,
cord-006702-ekf6mja9	206	11	G3	G3	NNP
cord-006702-ekf6mja9	206	12	N=1	N=1	NNP
cord-006702-ekf6mja9	206	13	,	,	,
cord-006702-ekf6mja9	206	14	23	23	CD
cord-006702-ekf6mja9	206	15	,	,	,
cord-006702-ekf6mja9	206	16	32	32	CD
cord-006702-ekf6mja9	206	17	and	and	CC
cord-006702-ekf6mja9	206	18	33	33	CD
cord-006702-ekf6mja9	206	19	years	year	NNS
cord-006702-ekf6mja9	206	20	)	)	-RRB-
cord-006702-ekf6mja9	206	21	,	,	,
cord-006702-ekf6mja9	206	22	and	and	CC
cord-006702-ekf6mja9	206	23	one	one	CD
cord-006702-ekf6mja9	206	24	patients	patient	NNS
cord-006702-ekf6mja9	206	25	underwent	undergo	VBD
cord-006702-ekf6mja9	206	26	combined	combined	JJ
cord-006702-ekf6mja9	206	27	kidney	kidney	NN
cord-006702-ekf6mja9	206	28	/	/	SYM
cord-006702-ekf6mja9	206	29	liver	liver	NN
cord-006702-ekf6mja9	206	30	transplantation	transplantation	NN
cord-006702-ekf6mja9	206	31	(	(	-LRB-
cord-006702-ekf6mja9	206	32	G2	G2	NNP
cord-006702-ekf6mja9	206	33	,	,	,
cord-006702-ekf6mja9	206	34	23	23	CD
cord-006702-ekf6mja9	206	35	yrs	yr	NNS
cord-006702-ekf6mja9	206	36	)	)	-RRB-
cord-006702-ekf6mja9	206	37	.	.	.
cord-006702-ekf6mja9	207	1	Seven	seven	CD
cord-006702-ekf6mja9	207	2	patients	patient	NNS
cord-006702-ekf6mja9	207	3	died	die	VBD
cord-006702-ekf6mja9	207	4	after	after	IN
cord-006702-ekf6mja9	207	5	the	the	DT
cord-006702-ekf6mja9	207	6	neonatal	neonatal	JJ
cord-006702-ekf6mja9	207	7	period	period	NN
cord-006702-ekf6mja9	207	8	,	,	,
cord-006702-ekf6mja9	207	9	2	2	CD
cord-006702-ekf6mja9	207	10	from	from	IN
cord-006702-ekf6mja9	207	11	G1	G1	NNP
cord-006702-ekf6mja9	207	12	,	,	,
cord-006702-ekf6mja9	207	13	3	3	CD
cord-006702-ekf6mja9	207	14	from	from	IN
cord-006702-ekf6mja9	207	15	G2	G2	NNP
cord-006702-ekf6mja9	207	16	and	and	CC
cord-006702-ekf6mja9	207	17	2	2	CD
cord-006702-ekf6mja9	207	18	from	from	IN
cord-006702-ekf6mja9	207	19	G3	G3	NNP
cord-006702-ekf6mja9	207	20	(	(	-LRB-
cord-006702-ekf6mja9	207	21	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	207	22	)	)	-RRB-
cord-006702-ekf6mja9	207	23	.	.	.
cord-006702-ekf6mja9	208	1	The	the	DT
cord-006702-ekf6mja9	208	2	presence	presence	NN
cord-006702-ekf6mja9	208	3	of	of	IN
cord-006702-ekf6mja9	208	4	two	two	CD
cord-006702-ekf6mja9	208	5	truncating	truncate	VBG
cord-006702-ekf6mja9	208	6	mutations	mutation	NNS
cord-006702-ekf6mja9	208	7	in	in	IN
cord-006702-ekf6mja9	208	8	PKHD1	PKHD1	NNS
cord-006702-ekf6mja9	208	9	is	be	VBZ
cord-006702-ekf6mja9	208	10	associated	associate	VBN
cord-006702-ekf6mja9	208	11	with	with	IN
cord-006702-ekf6mja9	208	12	a	a	DT
cord-006702-ekf6mja9	208	13	more	more	RBR
cord-006702-ekf6mja9	208	14	severe	severe	JJ
cord-006702-ekf6mja9	208	15	perinatal	perinatal	JJ
cord-006702-ekf6mja9	208	16	and	and	CC
cord-006702-ekf6mja9	208	17	later	later	RB
cord-006702-ekf6mja9	208	18	-	-	HYPH
cord-006702-ekf6mja9	208	19	in	in	IN
cord-006702-ekf6mja9	208	20	-	-	HYPH
cord-006702-ekf6mja9	208	21	life	life	NN
cord-006702-ekf6mja9	208	22	phenotype	phenotype	NN
cord-006702-ekf6mja9	208	23	.	.	.
cord-006702-ekf6mja9	209	1	However	however	RB
cord-006702-ekf6mja9	209	2	,	,	,
cord-006702-ekf6mja9	209	3	there	there	EX
cord-006702-ekf6mja9	209	4	is	be	VBZ
cord-006702-ekf6mja9	209	5	a	a	DT
cord-006702-ekf6mja9	209	6	phenotypic	phenotypic	JJ
cord-006702-ekf6mja9	209	7	variability	variability	NN
cord-006702-ekf6mja9	209	8	that	that	WDT
cord-006702-ekf6mja9	209	9	requires	require	VBZ
cord-006702-ekf6mja9	209	10	great	great	JJ
cord-006702-ekf6mja9	209	11	caution	caution	NN
cord-006702-ekf6mja9	209	12	during	during	IN
cord-006702-ekf6mja9	209	13	prenatal	prenatal	JJ
cord-006702-ekf6mja9	209	14	councelling	councelling	NN
cord-006702-ekf6mja9	209	15	.	.	.
cord-006702-ekf6mja9	210	1	FP	FP	NNP
cord-006702-ekf6mja9	210	2	-	-	HYPH
cord-006702-ekf6mja9	210	3	S08	S08	NNP
cord-006702-ekf6mja9	210	4	-	-	HYPH
cord-006702-ekf6mja9	210	5	2	2	CD
cord-006702-ekf6mja9	210	6	3D	3D	NNP
cord-006702-ekf6mja9	210	7	-	-	:
cord-006702-ekf6mja9	210	8	US	US	NNP
cord-006702-ekf6mja9	210	9	with	with	IN
cord-006702-ekf6mja9	210	10	a	a	DT
cord-006702-ekf6mja9	210	11	correction	correction	NN
cord-006702-ekf6mja9	210	12	factor	factor	NN
cord-006702-ekf6mja9	210	13	is	be	VBZ
cord-006702-ekf6mja9	210	14	a	a	DT
cord-006702-ekf6mja9	210	15	good	good	JJ
cord-006702-ekf6mja9	210	16	alternative	alternative	NN
cord-006702-ekf6mja9	210	17	in	in	IN
cord-006702-ekf6mja9	210	18	estimating	estimate	VBG
cord-006702-ekf6mja9	210	19	total	total	JJ
cord-006702-ekf6mja9	210	20	kidney	kidney	NN
cord-006702-ekf6mja9	210	21	volume	volume	NN
cord-006702-ekf6mja9	210	22	in	in	IN
cord-006702-ekf6mja9	210	23	children	child	NNS
cord-006702-ekf6mja9	210	24	with	with	IN
cord-006702-ekf6mja9	210	25	Objectives	objective	NNS
cord-006702-ekf6mja9	210	26	:	:	:
cord-006702-ekf6mja9	210	27	Total	total	JJ
cord-006702-ekf6mja9	210	28	kidney	kidney	NN
cord-006702-ekf6mja9	210	29	volume	volume	NN
cord-006702-ekf6mja9	210	30	(	(	-LRB-
cord-006702-ekf6mja9	210	31	TKV	TKV	NNP
cord-006702-ekf6mja9	210	32	)	)	-RRB-
cord-006702-ekf6mja9	210	33	has	have	VBZ
cord-006702-ekf6mja9	210	34	been	be	VBN
cord-006702-ekf6mja9	210	35	shown	show	VBN
cord-006702-ekf6mja9	210	36	in	in	IN
cord-006702-ekf6mja9	210	37	adult	adult	NN
cord-006702-ekf6mja9	210	38	Autosomal	autosomal	JJ
cord-006702-ekf6mja9	210	39	Dominant	dominant	JJ
cord-006702-ekf6mja9	210	40	Polycystic	polycystic	JJ
cord-006702-ekf6mja9	210	41	Kidney	kidney	NN
cord-006702-ekf6mja9	210	42	Disease	Disease	NNP
cord-006702-ekf6mja9	210	43	(	(	-LRB-
cord-006702-ekf6mja9	210	44	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	210	45	)	)	-RRB-
cord-006702-ekf6mja9	210	46	to	to	TO
cord-006702-ekf6mja9	210	47	be	be	VB
cord-006702-ekf6mja9	210	48	an	an	DT
cord-006702-ekf6mja9	210	49	independent	independent	JJ
cord-006702-ekf6mja9	210	50	and	and	CC
cord-006702-ekf6mja9	210	51	strong	strong	JJ
cord-006702-ekf6mja9	210	52	predictor	predictor	NN
cord-006702-ekf6mja9	210	53	for	for	IN
cord-006702-ekf6mja9	210	54	disease	disease	NN
cord-006702-ekf6mja9	210	55	progression	progression	NN
cord-006702-ekf6mja9	210	56	.	.	.
cord-006702-ekf6mja9	211	1	In	in	IN
cord-006702-ekf6mja9	211	2	the	the	DT
cord-006702-ekf6mja9	211	3	current	current	JJ
cord-006702-ekf6mja9	211	4	interventional	interventional	JJ
cord-006702-ekf6mja9	211	5	clinical	clinical	JJ
cord-006702-ekf6mja9	211	6	trials	trial	NNS
cord-006702-ekf6mja9	211	7	,	,	,
cord-006702-ekf6mja9	211	8	TKV	TKV	NNP
cord-006702-ekf6mja9	211	9	measurement	measurement	NN
cord-006702-ekf6mja9	211	10	by	by	IN
cord-006702-ekf6mja9	211	11	magnetic	magnetic	JJ
cord-006702-ekf6mja9	211	12	resonance	resonance	NN
cord-006702-ekf6mja9	212	1	(	(	-LRB-
cord-006702-ekf6mja9	212	2	MR	MR	NNP
cord-006702-ekf6mja9	212	3	)	)	-RRB-
cord-006702-ekf6mja9	212	4	imaging	imaging	NN
cord-006702-ekf6mja9	212	5	has	have	VBZ
cord-006702-ekf6mja9	212	6	been	be	VBN
cord-006702-ekf6mja9	212	7	shown	show	VBN
cord-006702-ekf6mja9	212	8	to	to	TO
cord-006702-ekf6mja9	212	9	be	be	VB
cord-006702-ekf6mja9	212	10	more	more	RBR
cord-006702-ekf6mja9	212	11	accurate	accurate	JJ
cord-006702-ekf6mja9	212	12	,	,	,
cord-006702-ekf6mja9	212	13	reproducible	reproducible	JJ
cord-006702-ekf6mja9	212	14	and	and	CC
cord-006702-ekf6mja9	212	15	able	able	JJ
cord-006702-ekf6mja9	212	16	to	to	TO
cord-006702-ekf6mja9	212	17	detect	detect	VB
cord-006702-ekf6mja9	212	18	small	small	JJ
cord-006702-ekf6mja9	212	19	changes	change	NNS
cord-006702-ekf6mja9	212	20	over	over	IN
cord-006702-ekf6mja9	212	21	a	a	DT
cord-006702-ekf6mja9	212	22	short	short	JJ
cord-006702-ekf6mja9	212	23	period	period	NN
cord-006702-ekf6mja9	212	24	of	of	IN
cord-006702-ekf6mja9	212	25	time	time	NN
cord-006702-ekf6mja9	212	26	compared	compare	VBN
cord-006702-ekf6mja9	212	27	to	to	IN
cord-006702-ekf6mja9	212	28	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	212	29	(	(	-LRB-
cord-006702-ekf6mja9	212	30	US	US	NNP
cord-006702-ekf6mja9	212	31	)	)	-RRB-
cord-006702-ekf6mja9	212	32	.	.	.
cord-006702-ekf6mja9	213	1	Since	since	IN
cord-006702-ekf6mja9	213	2	future	future	JJ
cord-006702-ekf6mja9	213	3	therapies	therapy	NNS
cord-006702-ekf6mja9	213	4	in	in	IN
cord-006702-ekf6mja9	213	5	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	213	6	could	could	MD
cord-006702-ekf6mja9	213	7	be	be	VB
cord-006702-ekf6mja9	213	8	extended	extend	VBN
cord-006702-ekf6mja9	213	9	to	to	TO
cord-006702-ekf6mja9	213	10	include	include	VB
cord-006702-ekf6mja9	213	11	children	child	NNS
cord-006702-ekf6mja9	213	12	,	,	,
cord-006702-ekf6mja9	213	13	we	-PRON-	PRP
cord-006702-ekf6mja9	213	14	aimed	aim	VBD
cord-006702-ekf6mja9	213	15	to	to	TO
cord-006702-ekf6mja9	213	16	examine	examine	VB
cord-006702-ekf6mja9	213	17	whether	whether	IN
cord-006702-ekf6mja9	213	18	the	the	DT
cord-006702-ekf6mja9	213	19	high	high	JJ
cord-006702-ekf6mja9	213	20	-	-	HYPH
cord-006702-ekf6mja9	213	21	resolution	resolution	NN
cord-006702-ekf6mja9	213	22	3D	3d	NN
cord-006702-ekf6mja9	213	23	-	-	.
cord-006702-ekf6mja9	213	24	US	US	NNP
cord-006702-ekf6mja9	213	25	TKV	TKV	NNP
cord-006702-ekf6mja9	213	26	measurements	measurement	NNS
cord-006702-ekf6mja9	213	27	might	may	MD
cord-006702-ekf6mja9	213	28	be	be	VB
cord-006702-ekf6mja9	213	29	used	use	VBN
cord-006702-ekf6mja9	213	30	as	as	IN
cord-006702-ekf6mja9	213	31	an	an	DT
cord-006702-ekf6mja9	213	32	alternative	alternative	JJ
cord-006702-ekf6mja9	213	33	method	method	NN
cord-006702-ekf6mja9	213	34	to	to	IN
cord-006702-ekf6mja9	213	35	MR	MR	NNP
cord-006702-ekf6mja9	213	36	measurements	measurement	NNS
cord-006702-ekf6mja9	213	37	in	in	IN
cord-006702-ekf6mja9	213	38	ADPKD	ADPKD	NNP
cord-006702-ekf6mja9	213	39	children	child	NNS
cord-006702-ekf6mja9	213	40	Methods	method	NNS
cord-006702-ekf6mja9	213	41	:	:	:
cord-006702-ekf6mja9	214	1	Prospective	prospective	JJ
cord-006702-ekf6mja9	214	2	evaluations	evaluation	NNS
cord-006702-ekf6mja9	214	3	of	of	IN
cord-006702-ekf6mja9	214	4	renal	renal	JJ
cord-006702-ekf6mja9	214	5	MR	MR	NNP
cord-006702-ekf6mja9	214	6	,	,	,
cord-006702-ekf6mja9	214	7	2D	2D	NNP
cord-006702-ekf6mja9	214	8	-	-	HYPH
cord-006702-ekf6mja9	214	9	and	and	CC
cord-006702-ekf6mja9	214	10	3D	3D	NNP
cord-006702-ekf6mja9	214	11	-	-	:
cord-006702-ekf6mja9	214	12	US	US	NNP
cord-006702-ekf6mja9	214	13	were	be	VBD
cord-006702-ekf6mja9	214	14	performed	perform	VBN
cord-006702-ekf6mja9	214	15	,	,	,
cord-006702-ekf6mja9	214	16	whereby	whereby	WRB
cord-006702-ekf6mja9	214	17	TKV	TKV	NNP
cord-006702-ekf6mja9	214	18	was	be	VBD
cord-006702-ekf6mja9	214	19	calculated	calculate	VBN
cord-006702-ekf6mja9	214	20	by	by	IN
cord-006702-ekf6mja9	214	21	means	mean	NNS
cord-006702-ekf6mja9	214	22	of	of	IN
cord-006702-ekf6mja9	214	23	manual	manual	JJ
cord-006702-ekf6mja9	214	24	delineations	delineation	NNS
cord-006702-ekf6mja9	214	25	(	(	-LRB-
cord-006702-ekf6mja9	214	26	MR	MR	NNP
cord-006702-ekf6mja9	214	27	,	,	,
cord-006702-ekf6mja9	214	28	3D	3D	NNP
cord-006702-ekf6mja9	214	29	-	-	:
cord-006702-ekf6mja9	214	30	US	US	NNP
cord-006702-ekf6mja9	214	31	)	)	-RRB-
cord-006702-ekf6mja9	214	32	or	or	CC
cord-006702-ekf6mja9	214	33	by	by	IN
cord-006702-ekf6mja9	214	34	the	the	DT
cord-006702-ekf6mja9	214	35	ellipsoid	ellipsoid	JJ
cord-006702-ekf6mja9	214	36	method	method	NN
cord-006702-ekf6mja9	214	37	(	(	-LRB-
cord-006702-ekf6mja9	214	38	2D	2D	NNP
cord-006702-ekf6mja9	214	39	-	-	:
cord-006702-ekf6mja9	214	40	US	US	NNP
cord-006702-ekf6mja9	214	41	)	)	-RRB-
cord-006702-ekf6mja9	214	42	.	.	.
cord-006702-ekf6mja9	215	1	Correlations	correlation	NNS
cord-006702-ekf6mja9	215	2	and	and	CC
cord-006702-ekf6mja9	215	3	differences	difference	NNS
cord-006702-ekf6mja9	215	4	between	between	IN
cord-006702-ekf6mja9	215	5	parameters	parameter	NNS
cord-006702-ekf6mja9	215	6	were	be	VBD
cord-006702-ekf6mja9	215	7	evaluated	evaluate	VBN
cord-006702-ekf6mja9	215	8	using	use	VBG
cord-006702-ekf6mja9	215	9	Pearson	Pearson	NNP
cord-006702-ekf6mja9	215	10	r	r	NNP
cord-006702-ekf6mja9	215	11	and	and	CC
cord-006702-ekf6mja9	215	12	Wilcoxon	Wilcoxon	NNP
cord-006702-ekf6mja9	215	13	signed	sign	VBD
cord-006702-ekf6mja9	215	14	rank	rank	NN
cord-006702-ekf6mja9	215	15	tests	test	NNS
cord-006702-ekf6mja9	215	16	.	.	.
cord-006702-ekf6mja9	216	1	After	after	IN
cord-006702-ekf6mja9	216	2	correction	correction	NN
cord-006702-ekf6mja9	216	3	using	use	VBG
cord-006702-ekf6mja9	216	4	the	the	DT
cord-006702-ekf6mja9	216	5	optimal	optimal	JJ
cord-006702-ekf6mja9	216	6	linear	linear	JJ
cord-006702-ekf6mja9	216	7	regression	regression	NN
cord-006702-ekf6mja9	216	8	,	,	,
cord-006702-ekf6mja9	216	9	the	the	DT
cord-006702-ekf6mja9	216	10	variability	variability	NN
cord-006702-ekf6mja9	216	11	of	of	IN
cord-006702-ekf6mja9	216	12	the	the	DT
cord-006702-ekf6mja9	216	13	measurements	measurement	NNS
cord-006702-ekf6mja9	216	14	was	be	VBD
cord-006702-ekf6mja9	216	15	examined	examine	VBN
cord-006702-ekf6mja9	216	16	using	use	VBG
cord-006702-ekf6mja9	216	17	Bland	Bland	NNP
cord-006702-ekf6mja9	216	18	-	-	HYPH
cord-006702-ekf6mja9	216	19	Altman	Altman	NNP
cord-006702-ekf6mja9	216	20	plots	plot	NNS
cord-006702-ekf6mja9	216	21	Results	result	NNS
cord-006702-ekf6mja9	216	22	:	:	:
cord-006702-ekf6mja9	216	23	We	-PRON-	PRP
cord-006702-ekf6mja9	216	24	studied	study	VBD
cord-006702-ekf6mja9	216	25	29	29	CD
cord-006702-ekf6mja9	216	26	patients	patient	NNS
cord-006702-ekf6mja9	216	27	(	(	-LRB-
cord-006702-ekf6mja9	216	28	17	17	CD
cord-006702-ekf6mja9	216	29	male	male	NN
cord-006702-ekf6mja9	216	30	,	,	,
cord-006702-ekf6mja9	216	31	12	12	CD
cord-006702-ekf6mja9	216	32	female	female	NN
cord-006702-ekf6mja9	216	33	)	)	-RRB-
cord-006702-ekf6mja9	216	34	with	with	IN
cord-006702-ekf6mja9	216	35	a	a	DT
cord-006702-ekf6mja9	216	36	median	median	JJ
cord-006702-ekf6mja9	216	37	age	age	NN
cord-006702-ekf6mja9	216	38	(	(	-LRB-
cord-006702-ekf6mja9	216	39	SD	SD	NNP
cord-006702-ekf6mja9	216	40	)	)	-RRB-
cord-006702-ekf6mja9	216	41	of	of	IN
cord-006702-ekf6mja9	216	42	14.0	14.0	CD
cord-006702-ekf6mja9	216	43	(	(	-LRB-
cord-006702-ekf6mja9	216	44	3.4	3.4	CD
cord-006702-ekf6mja9	216	45	)	)	-RRB-
cord-006702-ekf6mja9	216	46	years	year	NNS
cord-006702-ekf6mja9	216	47	and	and	CC
cord-006702-ekf6mja9	216	48	eGFR	egfr	NN
cord-006702-ekf6mja9	216	49	111	111	CD
cord-006702-ekf6mja9	216	50	(	(	-LRB-
cord-006702-ekf6mja9	216	51	17	17	CD
cord-006702-ekf6mja9	216	52	)	)	-RRB-
cord-006702-ekf6mja9	217	1	Objectives	objective	NNS
cord-006702-ekf6mja9	217	2	:	:	:
cord-006702-ekf6mja9	217	3	Mutations	mutation	NNS
cord-006702-ekf6mja9	217	4	of	of	IN
cord-006702-ekf6mja9	217	5	the	the	DT
cord-006702-ekf6mja9	217	6	Pkhd1	pkhd1	JJ
cord-006702-ekf6mja9	217	7	gene	gene	NN
cord-006702-ekf6mja9	217	8	cause	cause	VB
cord-006702-ekf6mja9	217	9	autosomal	autosomal	JJ
cord-006702-ekf6mja9	217	10	recessive	recessive	JJ
cord-006702-ekf6mja9	217	11	polycystic	polycystic	JJ
cord-006702-ekf6mja9	217	12	kidney	kidney	NN
cord-006702-ekf6mja9	217	13	disease	disease	NN
cord-006702-ekf6mja9	217	14	(	(	-LRB-
cord-006702-ekf6mja9	217	15	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	217	16	)	)	-RRB-
cord-006702-ekf6mja9	217	17	.	.	.
cord-006702-ekf6mja9	218	1	Pkhd1	Pkhd1	NNP
cord-006702-ekf6mja9	218	2	encodes	encode	VBZ
cord-006702-ekf6mja9	218	3	fibrocystin	fibrocystin	NNP
cord-006702-ekf6mja9	218	4	(	(	-LRB-
cord-006702-ekf6mja9	218	5	FPC	FPC	NNP
cord-006702-ekf6mja9	218	6	)	)	-RRB-
cord-006702-ekf6mja9	218	7	,	,	,
cord-006702-ekf6mja9	218	8	a	a	DT
cord-006702-ekf6mja9	218	9	ciliary	ciliary	NN
cord-006702-ekf6mja9	218	10	type	type	NN
cord-006702-ekf6mja9	218	11	I	-PRON-	PRP
cord-006702-ekf6mja9	218	12	membrane	membrane	VBP
cord-006702-ekf6mja9	218	13	protein	protein	NN
cord-006702-ekf6mja9	218	14	of	of	IN
cord-006702-ekf6mja9	218	15	largely	largely	RB
cord-006702-ekf6mja9	218	16	unknown	unknown	JJ
cord-006702-ekf6mja9	218	17	function	function	NN
cord-006702-ekf6mja9	218	18	,	,	,
cord-006702-ekf6mja9	218	19	suggested	suggest	VBD
cord-006702-ekf6mja9	218	20	to	to	TO
cord-006702-ekf6mja9	218	21	affect	affect	VB
cord-006702-ekf6mja9	218	22	adhesion	adhesion	NN
cord-006702-ekf6mja9	218	23	signaling	signal	VBG
cord-006702-ekf6mja9	218	24	of	of	IN
cord-006702-ekf6mja9	218	25	cells	cell	NNS
cord-006702-ekf6mja9	218	26	.	.	.
cord-006702-ekf6mja9	219	1	Contributions	contribution	NNS
cord-006702-ekf6mja9	219	2	of	of	IN
cord-006702-ekf6mja9	219	3	epithelial	epithelial	JJ
cord-006702-ekf6mja9	219	4	cell	cell	NN
cord-006702-ekf6mja9	219	5	adhesion	adhesion	NN
cord-006702-ekf6mja9	219	6	and	and	CC
cord-006702-ekf6mja9	219	7	contractility	contractility	NN
cord-006702-ekf6mja9	219	8	to	to	IN
cord-006702-ekf6mja9	219	9	the	the	DT
cord-006702-ekf6mja9	219	10	disease	disease	NN
cord-006702-ekf6mja9	219	11	process	process	NN
cord-006702-ekf6mja9	219	12	of	of	IN
cord-006702-ekf6mja9	219	13	ARPKD	ARPKD	NNP
cord-006702-ekf6mja9	219	14	are	be	VBP
cord-006702-ekf6mja9	219	15	elusive	elusive	JJ
cord-006702-ekf6mja9	219	16	.	.	.
cord-006702-ekf6mja9	220	1	Here	here	RB
cord-006702-ekf6mja9	220	2	,	,	,
cord-006702-ekf6mja9	220	3	we	-PRON-	PRP
cord-006702-ekf6mja9	220	4	establish	establish	VBP
cord-006702-ekf6mja9	220	5	a	a	DT
cord-006702-ekf6mja9	220	6	link	link	NN
cord-006702-ekf6mja9	220	7	between	between	IN
cord-006702-ekf6mja9	220	8	loss	loss	NN
cord-006702-ekf6mja9	220	9	of	of	IN
cord-006702-ekf6mja9	220	10	FPC	FPC	NNP
cord-006702-ekf6mja9	220	11	function	function	NN
cord-006702-ekf6mja9	220	12	and	and	CC
cord-006702-ekf6mja9	220	13	epithelial	epithelial	JJ
cord-006702-ekf6mja9	220	14	morphogenesis	morphogenesis	NN
cord-006702-ekf6mja9	220	15	in	in	IN
cord-006702-ekf6mja9	220	16	3D	3d	JJ
cord-006702-ekf6mja9	220	17	cell	cell	NN
cord-006702-ekf6mja9	220	18	culture	culture	NN
cord-006702-ekf6mja9	220	19	,	,	,
cord-006702-ekf6mja9	220	20	cell	cell	NN
cord-006702-ekf6mja9	220	21	contact	contact	NN
cord-006702-ekf6mja9	220	22	formation	formation	NN
cord-006702-ekf6mja9	220	23	and	and	CC
cord-006702-ekf6mja9	220	24	cytoskelal	cytoskelal	NN
cord-006702-ekf6mja9	220	25	networks	network	NNS
cord-006702-ekf6mja9	220	26	.	.	.
cord-006702-ekf6mja9	221	1	Methods	method	NNS
cord-006702-ekf6mja9	221	2	:	:	:
cord-006702-ekf6mja9	221	3	We	-PRON-	PRP
cord-006702-ekf6mja9	221	4	analyze	analyze	VBP
cord-006702-ekf6mja9	221	5	FPC	FPC	NNP
cord-006702-ekf6mja9	221	6	function	function	NN
cord-006702-ekf6mja9	221	7	in	in	IN
cord-006702-ekf6mja9	221	8	Madin	Madin	NNP
cord-006702-ekf6mja9	221	9	-	-	HYPH
cord-006702-ekf6mja9	221	10	Darby	Darby	NNP
cord-006702-ekf6mja9	221	11	canine	canine	JJ
cord-006702-ekf6mja9	221	12	renal	renal	JJ
cord-006702-ekf6mja9	221	13	collecting	collect	VBG
cord-006702-ekf6mja9	221	14	duct	duct	NN
cord-006702-ekf6mja9	221	15	epithelial	epithelial	JJ
cord-006702-ekf6mja9	221	16	cells	cell	NNS
cord-006702-ekf6mja9	221	17	(	(	-LRB-
cord-006702-ekf6mja9	221	18	MDCK	MDCK	NNP
cord-006702-ekf6mja9	221	19	)	)	-RRB-
cord-006702-ekf6mja9	221	20	based	base	VBN
cord-006702-ekf6mja9	221	21	on	on	IN
cord-006702-ekf6mja9	221	22	Pkhd1	pkhd1	JJ
cord-006702-ekf6mja9	221	23	silencing	silencing	NN
cord-006702-ekf6mja9	221	24	.	.	.
cord-006702-ekf6mja9	222	1	Cells	cell	NNS
cord-006702-ekf6mja9	222	2	are	be	VBP
cord-006702-ekf6mja9	222	3	studied	study	VBN
cord-006702-ekf6mja9	222	4	on	on	IN
cord-006702-ekf6mja9	222	5	micro	micro	JJ
cord-006702-ekf6mja9	222	6	-	-	JJ
cord-006702-ekf6mja9	222	7	pattered	pattered	JJ
cord-006702-ekf6mja9	222	8	chips	chip	NNS
cord-006702-ekf6mja9	222	9	in	in	IN
cord-006702-ekf6mja9	222	10	3D	3d	JJ
cord-006702-ekf6mja9	222	11	cell	cell	NN
cord-006702-ekf6mja9	222	12	culture	culture	NN
cord-006702-ekf6mja9	222	13	conditions	condition	NNS
cord-006702-ekf6mja9	222	14	allowing	allow	VBG
cord-006702-ekf6mja9	222	15	analysis	analysis	NN
cord-006702-ekf6mja9	222	16	of	of	IN
cord-006702-ekf6mja9	222	17	polarity	polarity	NN
cord-006702-ekf6mja9	222	18	,	,	,
cord-006702-ekf6mja9	222	19	lumen	lumen	NN
cord-006702-ekf6mja9	222	20	formation	formation	NN
cord-006702-ekf6mja9	222	21	and	and	CC
cord-006702-ekf6mja9	222	22	ciliogenesis	ciliogenesis	NN
cord-006702-ekf6mja9	222	23	in	in	IN
cord-006702-ekf6mja9	222	24	epithelial	epithelial	JJ
cord-006702-ekf6mja9	222	25	spheroids	spheroid	NNS
cord-006702-ekf6mja9	222	26	.	.	.
cord-006702-ekf6mja9	223	1	Quantitative	quantitative	JJ
cord-006702-ekf6mja9	223	2	automated	automate	VBN
cord-006702-ekf6mja9	223	3	image	image	NN
cord-006702-ekf6mja9	223	4	processing	processing	NN
cord-006702-ekf6mja9	223	5	is	be	VBZ
cord-006702-ekf6mja9	223	6	applied	apply	VBN
cord-006702-ekf6mja9	223	7	to	to	TO
cord-006702-ekf6mja9	223	8	analyze	analyze	VB
cord-006702-ekf6mja9	223	9	z	z	NNP
cord-006702-ekf6mja9	223	10	-	-	HYPH
cord-006702-ekf6mja9	223	11	stacks	stack	NNS
cord-006702-ekf6mja9	223	12	of	of	IN
cord-006702-ekf6mja9	223	13	5-color	5-color	CD
cord-006702-ekf6mja9	223	14	fluorescence	fluorescence	NN
cord-006702-ekf6mja9	223	15	images	image	NNS
cord-006702-ekf6mja9	223	16	.	.	.
cord-006702-ekf6mja9	224	1	To	to	TO
cord-006702-ekf6mja9	224	2	determine	determine	VB
cord-006702-ekf6mja9	224	3	critical	critical	JJ
cord-006702-ekf6mja9	224	4	differences	difference	NNS
cord-006702-ekf6mja9	224	5	in	in	IN
cord-006702-ekf6mja9	224	6	cell	cell	NN
cord-006702-ekf6mja9	224	7	adhesion	adhesion	NN
cord-006702-ekf6mja9	224	8	parameters	parameter	NNS
cord-006702-ekf6mja9	224	9	,	,	,
cord-006702-ekf6mja9	224	10	MDCK	MDCK	NNP
cord-006702-ekf6mja9	224	11	cells	cell	NNS
cord-006702-ekf6mja9	224	12	are	be	VBP
cord-006702-ekf6mja9	224	13	studied	study	VBN
cord-006702-ekf6mja9	224	14	also	also	RB
cord-006702-ekf6mja9	224	15	on	on	IN
cord-006702-ekf6mja9	224	16	chips	chip	NNS
cord-006702-ekf6mja9	224	17	in	in	IN
cord-006702-ekf6mja9	224	18	their	-PRON-	PRP$
cord-006702-ekf6mja9	224	19	one	one	CD
cord-006702-ekf6mja9	224	20	and	and	CC
cord-006702-ekf6mja9	224	21	2(4)-cell	2(4)-cell	CD
cord-006702-ekf6mja9	224	22	stages	stage	NNS
cord-006702-ekf6mja9	224	23	.	.	.
cord-006702-ekf6mja9	225	1	Activation	activation	NN
cord-006702-ekf6mja9	225	2	of	of	IN
cord-006702-ekf6mja9	225	3	adhesion	adhesion	NN
cord-006702-ekf6mja9	225	4	signaling	signaling	NN
cord-006702-ekf6mja9	225	5	is	be	VBZ
cord-006702-ekf6mja9	225	6	addressed	address	VBN
cord-006702-ekf6mja9	225	7	based	base	VBN
cord-006702-ekf6mja9	225	8	on	on	IN
cord-006702-ekf6mja9	225	9	phosphorylation	phosphorylation	NN
cord-006702-ekf6mja9	225	10	of	of	IN
cord-006702-ekf6mja9	225	11	the	the	DT
cord-006702-ekf6mja9	225	12	FAK	FAK	NNP
cord-006702-ekf6mja9	225	13	/	/	SYM
cord-006702-ekf6mja9	225	14	Src	Src	NNP
cord-006702-ekf6mja9	225	15	axis	axis	NN
cord-006702-ekf6mja9	225	16	.	.	.
cord-006702-ekf6mja9	226	1	Results	result	NNS
cord-006702-ekf6mja9	226	2	:	:	:
cord-006702-ekf6mja9	227	1	Using	use	VBG
cord-006702-ekf6mja9	227	2	defined	define	VBN
cord-006702-ekf6mja9	227	3	adhesion	adhesion	NN
cord-006702-ekf6mja9	227	4	conditions	condition	NNS
cord-006702-ekf6mja9	227	5	,	,	,
cord-006702-ekf6mja9	227	6	we	-PRON-	PRP
cord-006702-ekf6mja9	227	7	quantified	quantify	VBD
cord-006702-ekf6mja9	227	8	the	the	DT
cord-006702-ekf6mja9	227	9	impact	impact	NN
cord-006702-ekf6mja9	227	10	of	of	IN
cord-006702-ekf6mja9	227	11	FPC	FPC	NNP
cord-006702-ekf6mja9	227	12	deficiency	deficiency	NN
cord-006702-ekf6mja9	227	13	on	on	IN
cord-006702-ekf6mja9	227	14	size	size	NN
cord-006702-ekf6mja9	227	15	/	/	SYM
cord-006702-ekf6mja9	227	16	density	density	NN
cord-006702-ekf6mja9	227	17	of	of	IN
cord-006702-ekf6mja9	227	18	adhesion	adhesion	NN
cord-006702-ekf6mja9	227	19	sites	site	NNS
cord-006702-ekf6mja9	227	20	,	,	,
cord-006702-ekf6mja9	227	21	cell	cell	NN
cord-006702-ekf6mja9	227	22	shape	shape	NN
cord-006702-ekf6mja9	227	23	characteristics	characteristic	NNS
cord-006702-ekf6mja9	227	24	and	and	CC
cord-006702-ekf6mja9	227	25	initiation	initiation	NN
cord-006702-ekf6mja9	227	26	of	of	IN
cord-006702-ekf6mja9	227	27	an	an	DT
cord-006702-ekf6mja9	227	28	apical	apical	JJ
cord-006702-ekf6mja9	227	29	surface	surface	NN
cord-006702-ekf6mja9	227	30	.	.	.
cord-006702-ekf6mja9	228	1	Effects	effect	NNS
cord-006702-ekf6mja9	228	2	on	on	IN
cord-006702-ekf6mja9	228	3	apicobasal	apicobasal	NN
cord-006702-ekf6mja9	228	4	polarity	polarity	NN
cord-006702-ekf6mja9	228	5	and	and	CC
cord-006702-ekf6mja9	228	6	lumen	lumen	NN
cord-006702-ekf6mja9	228	7	formation	formation	NN
cord-006702-ekf6mja9	228	8	correlate	correlate	VBP
cord-006702-ekf6mja9	228	9	significantly	significantly	RB
cord-006702-ekf6mja9	228	10	with	with	IN
cord-006702-ekf6mja9	228	11	positioning	positioning	NN
cord-006702-ekf6mja9	228	12	of	of	IN
cord-006702-ekf6mja9	228	13	centrosomes	centrosome	NNS
cord-006702-ekf6mja9	228	14	in	in	IN
cord-006702-ekf6mja9	228	15	2(4)-cell	2(4)-cell	CD
cord-006702-ekf6mja9	228	16	stages	stage	NNS
cord-006702-ekf6mja9	228	17	and	and	CC
cord-006702-ekf6mja9	228	18	activation	activation	NN
cord-006702-ekf6mja9	228	19	of	of	IN
cord-006702-ekf6mja9	228	20	adhesion	adhesion	NN
cord-006702-ekf6mja9	228	21	signaling	signaling	NN
cord-006702-ekf6mja9	228	22	.	.	.
cord-006702-ekf6mja9	229	1	In	in	IN
cord-006702-ekf6mja9	229	2	addition	addition	NN
cord-006702-ekf6mja9	229	3	,	,	,
cord-006702-ekf6mja9	229	4	FPC	FPC	NNP
cord-006702-ekf6mja9	229	5	deficient	deficient	JJ
cord-006702-ekf6mja9	229	6	cells	cell	NNS
cord-006702-ekf6mja9	229	7	reveal	reveal	VBP
cord-006702-ekf6mja9	229	8	defects	defect	NNS
cord-006702-ekf6mja9	229	9	in	in	IN
cord-006702-ekf6mja9	229	10	the	the	DT
cord-006702-ekf6mja9	229	11	formation	formation	NN
cord-006702-ekf6mja9	229	12	of	of	IN
cord-006702-ekf6mja9	229	13	correctly	correctly	RB
cord-006702-ekf6mja9	229	14	polarized	polarized	JJ
cord-006702-ekf6mja9	229	15	epithelial	epithelial	JJ
cord-006702-ekf6mja9	229	16	spheroids	spheroid	NNS
cord-006702-ekf6mja9	229	17	.	.	.
cord-006702-ekf6mja9	230	1	Transient	transient	JJ
cord-006702-ekf6mja9	230	2	reduction	reduction	NN
cord-006702-ekf6mja9	230	3	of	of	IN
cord-006702-ekf6mja9	230	4	actomyosin	actomyosin	NNP
cord-006702-ekf6mja9	230	5	contractility	contractility	NN
cord-006702-ekf6mja9	230	6	restores	restore	VBZ
cord-006702-ekf6mja9	230	7	70	70	CD
cord-006702-ekf6mja9	230	8	%	%	NN
cord-006702-ekf6mja9	230	9	of	of	IN
cord-006702-ekf6mja9	230	10	correct	correct	JJ
cord-006702-ekf6mja9	230	11	epithelial	epithelial	JJ
cord-006702-ekf6mja9	230	12	morphogenesis	morphogenesis	NN
cord-006702-ekf6mja9	230	13	(	(	-LRB-
cord-006702-ekf6mja9	230	14	p<0.01	p<0.01	NNP
cord-006702-ekf6mja9	230	15	)	)	-RRB-
cord-006702-ekf6mja9	230	16	.	.	.
cord-006702-ekf6mja9	231	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	231	2	:	:	:
cord-006702-ekf6mja9	232	1	FPC	FPC	NNP
cord-006702-ekf6mja9	232	2	silencing	silence	VBG
cord-006702-ekf6mja9	232	3	in	in	IN
cord-006702-ekf6mja9	232	4	MDCK	MDCK	NNP
cord-006702-ekf6mja9	232	5	cells	cell	NNS
cord-006702-ekf6mja9	232	6	disturbs	disturb	VBZ
cord-006702-ekf6mja9	232	7	adhesion	adhesion	NN
cord-006702-ekf6mja9	232	8	signaling	signal	VBG
cord-006702-ekf6mja9	232	9	and	and	CC
cord-006702-ekf6mja9	232	10	cell	cell	NN
cord-006702-ekf6mja9	232	11	-	-	HYPH
cord-006702-ekf6mja9	232	12	cell	cell	NN
cord-006702-ekf6mja9	232	13	interaction	interaction	NN
cord-006702-ekf6mja9	232	14	resulting	result	VBG
cord-006702-ekf6mja9	232	15	in	in	IN
cord-006702-ekf6mja9	232	16	impaired	impaired	JJ
cord-006702-ekf6mja9	232	17	epithelial	epithelial	JJ
cord-006702-ekf6mja9	232	18	morphogenesis	morphogenesis	NN
cord-006702-ekf6mja9	232	19	.	.	.
cord-006702-ekf6mja9	233	1	Using	use	VBG
cord-006702-ekf6mja9	233	2	a	a	DT
cord-006702-ekf6mja9	233	3	cell	cell	NN
cord-006702-ekf6mja9	233	4	-	-	HYPH
cord-006702-ekf6mja9	233	5	based	base	VBN
cord-006702-ekf6mja9	233	6	model	model	NN
cord-006702-ekf6mja9	233	7	system	system	NN
cord-006702-ekf6mja9	233	8	,	,	,
cord-006702-ekf6mja9	233	9	we	-PRON-	PRP
cord-006702-ekf6mja9	233	10	address	address	VBP
cord-006702-ekf6mja9	233	11	molecular	molecular	JJ
cord-006702-ekf6mja9	233	12	consequences	consequence	NNS
cord-006702-ekf6mja9	233	13	of	of	IN
cord-006702-ekf6mja9	233	14	and	and	CC
cord-006702-ekf6mja9	233	15	analyze	analyze	VB
cord-006702-ekf6mja9	233	16	quantitatively	quantitatively	RB
cord-006702-ekf6mja9	233	17	rescue	rescue	VB
cord-006702-ekf6mja9	233	18	strategies	strategy	NNS
cord-006702-ekf6mja9	233	19	for	for	IN
cord-006702-ekf6mja9	233	20	FPC	FPC	NNP
cord-006702-ekf6mja9	233	21	deficiency	deficiency	NN
cord-006702-ekf6mja9	233	22	in	in	IN
cord-006702-ekf6mja9	233	23	collecting	collect	VBG
cord-006702-ekf6mja9	233	24	duct	duct	NN
cord-006702-ekf6mja9	233	25	epithelia	epithelium	NNS
cord-006702-ekf6mja9	233	26	.	.	.
cord-006702-ekf6mja9	234	1	followed	follow	VBN
cord-006702-ekf6mja9	234	2	by	by	IN
cord-006702-ekf6mja9	234	3	those	those	DT
cord-006702-ekf6mja9	234	4	on	on	IN
cord-006702-ekf6mja9	234	5	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	234	6	(	(	-LRB-
cord-006702-ekf6mja9	234	7	40.0	40.0	CD
cord-006702-ekf6mja9	234	8	,	,	,
cord-006702-ekf6mja9	234	9	p=<0.0001	p=<0.0001	NNS
cord-006702-ekf6mja9	234	10	)	)	-RRB-
cord-006702-ekf6mja9	234	11	but	but	CC
cord-006702-ekf6mja9	234	12	even	even	RB
cord-006702-ekf6mja9	234	13	those	those	DT
cord-006702-ekf6mja9	234	14	with	with	IN
cord-006702-ekf6mja9	234	15	high	high	JJ
cord-006702-ekf6mja9	234	16	score	score	NN
cord-006702-ekf6mja9	234	17	did	do	VBD
cord-006702-ekf6mja9	234	18	not	not	RB
cord-006702-ekf6mja9	234	19	reach	reach	VB
cord-006702-ekf6mja9	234	20	50	50	CD
cord-006702-ekf6mja9	234	21	%	%	NN
cord-006702-ekf6mja9	234	22	of	of	IN
cord-006702-ekf6mja9	234	23	the	the	DT
cord-006702-ekf6mja9	234	24	score	score	NN
cord-006702-ekf6mja9	234	25	.	.	.
cord-006702-ekf6mja9	235	1	On	on	IN
cord-006702-ekf6mja9	235	2	Multinomial	Multinomial	NNP
cord-006702-ekf6mja9	235	3	Logistic	Logistic	NNP
cord-006702-ekf6mja9	235	4	Regression	Regression	NNP
cord-006702-ekf6mja9	235	5	and	and	CC
cord-006702-ekf6mja9	235	6	using	use	VBG
cord-006702-ekf6mja9	235	7	those	those	DT
cord-006702-ekf6mja9	235	8	with	with	IN
cord-006702-ekf6mja9	235	9	high	high	JJ
cord-006702-ekf6mja9	235	10	scores	score	NNS
cord-006702-ekf6mja9	235	11	(	(	-LRB-
cord-006702-ekf6mja9	235	12	>	>	NFP
cord-006702-ekf6mja9	235	13	60	60	CD
cord-006702-ekf6mja9	235	14	)	)	-RRB-
cord-006702-ekf6mja9	235	15	as	as	IN
cord-006702-ekf6mja9	235	16	referent	referent	NN
cord-006702-ekf6mja9	235	17	group	group	NN
cord-006702-ekf6mja9	235	18	,	,	,
cord-006702-ekf6mja9	235	19	dialysis	dialysis	NN
cord-006702-ekf6mja9	235	20	patients	patient	NNS
cord-006702-ekf6mja9	235	21	had	have	VBD
cord-006702-ekf6mja9	235	22	a	a	DT
cord-006702-ekf6mja9	235	23	significantly	significantly	RB
cord-006702-ekf6mja9	235	24	lower	low	JJR
cord-006702-ekf6mja9	235	25	HCT	HCT	NNP
cord-006702-ekf6mja9	235	26	readiness	readiness	NN
cord-006702-ekf6mja9	235	27	score	score	NN
cord-006702-ekf6mja9	235	28	.	.	.
cord-006702-ekf6mja9	236	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	236	2	:	:	:
cord-006702-ekf6mja9	237	1	Despite	despite	IN
cord-006702-ekf6mja9	237	2	the	the	DT
cord-006702-ekf6mja9	237	3	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	237	4	difference	difference	NN
cord-006702-ekf6mja9	237	5	in	in	IN
cord-006702-ekf6mja9	237	6	the	the	DT
cord-006702-ekf6mja9	237	7	populations	population	NNS
cord-006702-ekf6mja9	237	8	served	serve	VBD
cord-006702-ekf6mja9	237	9	at	at	IN
cord-006702-ekf6mja9	237	10	both	both	DT
cord-006702-ekf6mja9	237	11	institutions	institution	NNS
cord-006702-ekf6mja9	237	12	,	,	,
cord-006702-ekf6mja9	237	13	the	the	DT
cord-006702-ekf6mja9	237	14	sample	sample	NN
cord-006702-ekf6mja9	237	15	's	's	POS
cord-006702-ekf6mja9	237	16	overall	overall	JJ
cord-006702-ekf6mja9	237	17	low	low	JJ
cord-006702-ekf6mja9	237	18	score	score	NN
cord-006702-ekf6mja9	237	19	.	.	.
cord-006702-ekf6mja9	238	1	Patients	patient	NNS
cord-006702-ekf6mja9	238	2	who	who	WP
cord-006702-ekf6mja9	238	3	have	have	VBP
cord-006702-ekf6mja9	238	4	a	a	DT
cord-006702-ekf6mja9	238	5	renal	renal	JJ
cord-006702-ekf6mja9	238	6	transplant	transplant	NN
cord-006702-ekf6mja9	238	7	had	have	VBD
cord-006702-ekf6mja9	238	8	the	the	DT
cord-006702-ekf6mja9	238	9	greatest	great	JJS
cord-006702-ekf6mja9	238	10	HCT	hct	NN
cord-006702-ekf6mja9	238	11	readiness	readiness	NN
cord-006702-ekf6mja9	238	12	scores	score	NNS
cord-006702-ekf6mja9	238	13	,	,	,
cord-006702-ekf6mja9	238	14	and	and	CC
cord-006702-ekf6mja9	238	15	this	this	DT
cord-006702-ekf6mja9	238	16	may	may	MD
cord-006702-ekf6mja9	238	17	reflect	reflect	VB
cord-006702-ekf6mja9	238	18	the	the	DT
cord-006702-ekf6mja9	238	19	more	more	RBR
cord-006702-ekf6mja9	238	20	intense	intense	JJ
cord-006702-ekf6mja9	238	21	preparation	preparation	NN
cord-006702-ekf6mja9	238	22	and	and	CC
cord-006702-ekf6mja9	238	23	patient	patient	NN
cord-006702-ekf6mja9	238	24	education	education	NN
cord-006702-ekf6mja9	238	25	prior	prior	RB
cord-006702-ekf6mja9	238	26	to	to	IN
cord-006702-ekf6mja9	238	27	transplantation	transplantation	NN
cord-006702-ekf6mja9	238	28	.	.	.
cord-006702-ekf6mja9	239	1	Three	three	CD
cord-006702-ekf6mja9	239	2	-	-	HYPH
cord-006702-ekf6mja9	239	3	year	year	NN
cord-006702-ekf6mja9	239	4	-	-	HYPH
cord-006702-ekf6mja9	239	5	pediatric	pediatric	JJ
cord-006702-ekf6mja9	239	6	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	239	7	dialysis	dialysis	NN
cord-006702-ekf6mja9	239	8	experience	experience	NN
cord-006702-ekf6mja9	239	9	in	in	IN
cord-006702-ekf6mja9	239	10	Benin	Benin	NNP
cord-006702-ekf6mja9	239	11	:	:	:
cord-006702-ekf6mja9	239	12	challenges	challenge	NNS
cord-006702-ekf6mja9	239	13	and	and	CC
cord-006702-ekf6mja9	239	14	successes	success	NNS
cord-006702-ekf6mja9	239	15	F.	F.	NNP
cord-006702-ekf6mja9	239	16	Lalya	Lalya	NNP
cord-006702-ekf6mja9	239	17	(	(	-LRB-
cord-006702-ekf6mja9	239	18	1	1	CD
cord-006702-ekf6mja9	239	19	)	)	-RRB-
cord-006702-ekf6mja9	239	20	,	,	,
cord-006702-ekf6mja9	239	21	Y.	Y.	NNP
cord-006702-ekf6mja9	239	22	Tohodjede	Tohodjede	NNP
cord-006702-ekf6mja9	239	23	(	(	-LRB-
cord-006702-ekf6mja9	239	24	1	1	CD
cord-006702-ekf6mja9	239	25	)	)	-RRB-
cord-006702-ekf6mja9	239	26	,	,	,
cord-006702-ekf6mja9	239	27	M.	M.	NNP
cord-006702-ekf6mja9	239	28	D'Almeida	D'Almeida	NNP
cord-006702-ekf6mja9	239	29	(	(	-LRB-
cord-006702-ekf6mja9	239	30	1	1	CD
cord-006702-ekf6mja9	239	31	)	)	-RRB-
cord-006702-ekf6mja9	239	32	,	,	,
cord-006702-ekf6mja9	239	33	A.	A.	NNP
cord-006702-ekf6mja9	239	34	Hadonou	Hadonou	NNP
cord-006702-ekf6mja9	239	35	(	(	-LRB-
cord-006702-ekf6mja9	239	36	2	2	CD
cord-006702-ekf6mja9	239	37	)	)	-RRB-
cord-006702-ekf6mja9	239	38	,	,	,
cord-006702-ekf6mja9	239	39	P.C.	P.C.	NNP
cord-006702-ekf6mja9	239	40	Hounkpe	Hounkpe	NNP
cord-006702-ekf6mja9	239	41	(	(	-LRB-
cord-006702-ekf6mja9	239	42	3	3	CD
cord-006702-ekf6mja9	239	43	)	)	-RRB-
cord-006702-ekf6mja9	239	44	,	,	,
cord-006702-ekf6mja9	239	45	B.	B.	NNP
cord-006702-ekf6mja9	239	46	Ayivi	Ayivi	NNP
cord-006702-ekf6mja9	239	47	(	(	-LRB-
cord-006702-ekf6mja9	239	48	1	1	CD
cord-006702-ekf6mja9	239	49	)	)	-RRB-
cord-006702-ekf6mja9	240	1	Objectives	objective	NNS
cord-006702-ekf6mja9	240	2	:	:	:
cord-006702-ekf6mja9	241	1	Nigeria	Nigeria	NNP
cord-006702-ekf6mja9	241	2	has	have	VBZ
cord-006702-ekf6mja9	241	3	the	the	DT
cord-006702-ekf6mja9	241	4	largest	large	JJS
cord-006702-ekf6mja9	241	5	burden	burden	NN
cord-006702-ekf6mja9	241	6	of	of	IN
cord-006702-ekf6mja9	241	7	sickle	sickle	NN
cord-006702-ekf6mja9	241	8	cell	cell	NN
cord-006702-ekf6mja9	241	9	anaemia	anaemia	NN
cord-006702-ekf6mja9	241	10	(	(	-LRB-
cord-006702-ekf6mja9	241	11	SCA	SCA	NNP
cord-006702-ekf6mja9	241	12	)	)	-RRB-
cord-006702-ekf6mja9	241	13	in	in	IN
cord-006702-ekf6mja9	241	14	the	the	DT
cord-006702-ekf6mja9	241	15	world	world	NN
cord-006702-ekf6mja9	241	16	.	.	.
cord-006702-ekf6mja9	242	1	Kidney	kidney	NN
cord-006702-ekf6mja9	242	2	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	242	3	are	be	VBP
cord-006702-ekf6mja9	242	4	established	establish	VBN
cord-006702-ekf6mja9	242	5	findings	finding	NNS
cord-006702-ekf6mja9	242	6	in	in	IN
cord-006702-ekf6mja9	242	7	children	child	NNS
cord-006702-ekf6mja9	242	8	with	with	IN
cord-006702-ekf6mja9	242	9	SCA	SCA	NNP
cord-006702-ekf6mja9	242	10	and	and	CC
cord-006702-ekf6mja9	242	11	are	be	VBP
cord-006702-ekf6mja9	242	12	known	know	VBN
cord-006702-ekf6mja9	242	13	to	to	TO
cord-006702-ekf6mja9	242	14	start	start	VB
cord-006702-ekf6mja9	242	15	early	early	RB
cord-006702-ekf6mja9	242	16	in	in	IN
cord-006702-ekf6mja9	242	17	childhood	childhood	NN
cord-006702-ekf6mja9	242	18	.	.	.
cord-006702-ekf6mja9	243	1	The	the	DT
cord-006702-ekf6mja9	243	2	study	study	NN
cord-006702-ekf6mja9	243	3	objective	objective	NN
cord-006702-ekf6mja9	243	4	was	be	VBD
cord-006702-ekf6mja9	243	5	to	to	TO
cord-006702-ekf6mja9	243	6	determine	determine	VB
cord-006702-ekf6mja9	243	7	the	the	DT
cord-006702-ekf6mja9	243	8	risk	risk	NN
cord-006702-ekf6mja9	243	9	factors	factor	NNS
cord-006702-ekf6mja9	243	10	associated	associate	VBN
cord-006702-ekf6mja9	243	11	with	with	IN
cord-006702-ekf6mja9	243	12	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	243	13	in	in	IN
cord-006702-ekf6mja9	243	14	children	child	NNS
cord-006702-ekf6mja9	243	15	with	with	IN
cord-006702-ekf6mja9	243	16	sickle	sickle	NN
cord-006702-ekf6mja9	243	17	cell	cell	NN
cord-006702-ekf6mja9	243	18	anaemia	anaemia	NN
cord-006702-ekf6mja9	243	19	and	and	CC
cord-006702-ekf6mja9	243	20	the	the	DT
cord-006702-ekf6mja9	243	21	relationship	relationship	NN
cord-006702-ekf6mja9	243	22	between	between	IN
cord-006702-ekf6mja9	243	23	it	-PRON-	PRP
cord-006702-ekf6mja9	243	24	and	and	CC
cord-006702-ekf6mja9	243	25	glomerular	glomerular	JJ
cord-006702-ekf6mja9	243	26	filtration	filtration	NN
cord-006702-ekf6mja9	243	27	rate	rate	NN
cord-006702-ekf6mja9	243	28	Methods	method	NNS
cord-006702-ekf6mja9	243	29	:	:	:
cord-006702-ekf6mja9	243	30	The	the	DT
cord-006702-ekf6mja9	243	31	study	study	NN
cord-006702-ekf6mja9	243	32	was	be	VBD
cord-006702-ekf6mja9	243	33	descriptive	descriptive	JJ
cord-006702-ekf6mja9	243	34	and	and	CC
cord-006702-ekf6mja9	243	35	cross	cross	JJ
cord-006702-ekf6mja9	243	36	sectional	sectional	JJ
cord-006702-ekf6mja9	243	37	involving	involve	VBG
cord-006702-ekf6mja9	243	38	323	323	CD
cord-006702-ekf6mja9	243	39	children	child	NNS
cord-006702-ekf6mja9	243	40	with	with	IN
cord-006702-ekf6mja9	243	41	sickle	sickle	NN
cord-006702-ekf6mja9	243	42	cell	cell	NN
cord-006702-ekf6mja9	243	43	anaemia	anaemia	NN
cord-006702-ekf6mja9	243	44	in	in	IN
cord-006702-ekf6mja9	243	45	steady	steady	JJ
cord-006702-ekf6mja9	243	46	state	state	NN
cord-006702-ekf6mja9	243	47	and	and	CC
cord-006702-ekf6mja9	243	48	equal	equal	JJ
cord-006702-ekf6mja9	243	49	number	number	NN
cord-006702-ekf6mja9	243	50	with	with	IN
cord-006702-ekf6mja9	243	51	normal	normal	JJ
cord-006702-ekf6mja9	243	52	haemoglobin	haemoglobin	NN
cord-006702-ekf6mja9	243	53	,	,	,
cord-006702-ekf6mja9	243	54	age	age	NN
cord-006702-ekf6mja9	243	55	and	and	CC
cord-006702-ekf6mja9	243	56	sex	sex	NN
cord-006702-ekf6mja9	243	57	matched	match	VBN
cord-006702-ekf6mja9	243	58	as	as	IN
cord-006702-ekf6mja9	243	59	control	control	NN
cord-006702-ekf6mja9	243	60	.	.	.
cord-006702-ekf6mja9	244	1	They	-PRON-	PRP
cord-006702-ekf6mja9	244	2	were	be	VBD
cord-006702-ekf6mja9	244	3	aged	age	VBN
cord-006702-ekf6mja9	244	4	6	6	CD
cord-006702-ekf6mja9	244	5	months	month	NNS
cord-006702-ekf6mja9	244	6	to	to	IN
cord-006702-ekf6mja9	244	7	18	18	CD
cord-006702-ekf6mja9	244	8	years	year	NNS
cord-006702-ekf6mja9	244	9	and	and	CC
cord-006702-ekf6mja9	244	10	consecutively	consecutively	RB
cord-006702-ekf6mja9	244	11	recruited	recruit	VBN
cord-006702-ekf6mja9	244	12	from	from	IN
cord-006702-ekf6mja9	244	13	the	the	DT
cord-006702-ekf6mja9	244	14	paediatric	paediatric	JJ
cord-006702-ekf6mja9	244	15	outpatient	outpatient	NN
cord-006702-ekf6mja9	244	16	department	department	NN
cord-006702-ekf6mja9	244	17	of	of	IN
cord-006702-ekf6mja9	244	18	the	the	DT
cord-006702-ekf6mja9	244	19	Jos	Jos	NNP
cord-006702-ekf6mja9	244	20	University	University	NNP
cord-006702-ekf6mja9	244	21	Teaching	Teaching	NNP
cord-006702-ekf6mja9	244	22	Hospital	Hospital	NNP
cord-006702-ekf6mja9	244	23	between	between	IN
cord-006702-ekf6mja9	244	24	September	September	NNP
cord-006702-ekf6mja9	244	25	and	and	CC
cord-006702-ekf6mja9	244	26	December	December	NNP
cord-006702-ekf6mja9	244	27	2013	2013	CD
cord-006702-ekf6mja9	244	28	.	.	.
cord-006702-ekf6mja9	245	1	Anthropometric	anthropometric	RB
cord-006702-ekf6mja9	245	2	,	,	,
cord-006702-ekf6mja9	245	3	demographic	demographic	JJ
cord-006702-ekf6mja9	245	4	characteristics	characteristic	NNS
cord-006702-ekf6mja9	245	5	and	and	CC
cord-006702-ekf6mja9	245	6	clinical	clinical	JJ
cord-006702-ekf6mja9	245	7	parameters	parameter	NNS
cord-006702-ekf6mja9	245	8	of	of	IN
cord-006702-ekf6mja9	245	9	each	each	DT
cord-006702-ekf6mja9	245	10	child	child	NN
cord-006702-ekf6mja9	245	11	and	and	CC
cord-006702-ekf6mja9	245	12	the	the	DT
cord-006702-ekf6mja9	245	13	social	social	JJ
cord-006702-ekf6mja9	245	14	status	status	NN
cord-006702-ekf6mja9	245	15	of	of	IN
cord-006702-ekf6mja9	245	16	the	the	DT
cord-006702-ekf6mja9	245	17	parents	parent	NNS
cord-006702-ekf6mja9	245	18	were	be	VBD
cord-006702-ekf6mja9	245	19	obtained	obtain	VBN
cord-006702-ekf6mja9	245	20	.	.	.
cord-006702-ekf6mja9	246	1	Spot	spot	JJ
cord-006702-ekf6mja9	246	2	urine	urine	NN
cord-006702-ekf6mja9	246	3	and	and	CC
cord-006702-ekf6mja9	246	4	venous	venous	JJ
cord-006702-ekf6mja9	246	5	blood	blood	NN
cord-006702-ekf6mja9	246	6	samples	sample	NNS
cord-006702-ekf6mja9	246	7	were	be	VBD
cord-006702-ekf6mja9	246	8	obtained	obtain	VBN
cord-006702-ekf6mja9	246	9	for	for	IN
cord-006702-ekf6mja9	246	10	determination	determination	NN
cord-006702-ekf6mja9	246	11	of	of	IN
cord-006702-ekf6mja9	246	12	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	246	13	,	,	,
cord-006702-ekf6mja9	246	14	packed	pack	VBN
cord-006702-ekf6mja9	246	15	cell	cell	NN
cord-006702-ekf6mja9	246	16	volume	volume	NN
cord-006702-ekf6mja9	246	17	and	and	CC
cord-006702-ekf6mja9	246	18	serum	serum	NN
cord-006702-ekf6mja9	246	19	creatinine	creatinine	NN
cord-006702-ekf6mja9	246	20	respectively	respectively	RB
cord-006702-ekf6mja9	246	21	.	.	.
cord-006702-ekf6mja9	247	1	Results	result	NNS
cord-006702-ekf6mja9	247	2	:	:	:
cord-006702-ekf6mja9	248	1	The	the	DT
cord-006702-ekf6mja9	248	2	prevalence	prevalence	NN
cord-006702-ekf6mja9	248	3	of	of	IN
cord-006702-ekf6mja9	248	4	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	248	5	in	in	IN
cord-006702-ekf6mja9	248	6	children	child	NNS
cord-006702-ekf6mja9	248	7	with	with	IN
cord-006702-ekf6mja9	248	8	SCA	SCA	NNP
cord-006702-ekf6mja9	248	9	was	be	VBD
cord-006702-ekf6mja9	248	10	26	26	CD
cord-006702-ekf6mja9	248	11	%	%	NN
cord-006702-ekf6mja9	248	12	in	in	IN
cord-006702-ekf6mja9	248	13	84	84	CD
cord-006702-ekf6mja9	248	14	children	child	NNS
cord-006702-ekf6mja9	248	15	,	,	,
cord-006702-ekf6mja9	248	16	compared	compare	VBN
cord-006702-ekf6mja9	248	17	to	to	IN
cord-006702-ekf6mja9	248	18	1.85	1.85	CD
cord-006702-ekf6mja9	248	19	%	%	NN
cord-006702-ekf6mja9	248	20	in	in	IN
cord-006702-ekf6mja9	248	21	controls	control	NNS
cord-006702-ekf6mja9	248	22	.	.	.
cord-006702-ekf6mja9	249	1	Of	of	IN
cord-006702-ekf6mja9	249	2	this	this	DT
cord-006702-ekf6mja9	249	3	,	,	,
cord-006702-ekf6mja9	249	4	87	87	CD
cord-006702-ekf6mja9	249	5	%	%	NN
cord-006702-ekf6mja9	249	6	were	be	VBD
cord-006702-ekf6mja9	249	7	aged	age	VBN
cord-006702-ekf6mja9	249	8	ten	ten	CD
cord-006702-ekf6mja9	249	9	years	year	NNS
cord-006702-ekf6mja9	249	10	or	or	CC
cord-006702-ekf6mja9	249	11	less	less	JJR
cord-006702-ekf6mja9	249	12	and	and	CC
cord-006702-ekf6mja9	249	13	there	there	EX
cord-006702-ekf6mja9	249	14	was	be	VBD
cord-006702-ekf6mja9	249	15	no	no	DT
cord-006702-ekf6mja9	249	16	sex	sex	NN
cord-006702-ekf6mja9	249	17	difference	difference	NN
cord-006702-ekf6mja9	249	18	.	.	.
cord-006702-ekf6mja9	250	1	Anaemia	anaemia	NN
cord-006702-ekf6mja9	250	2	and	and	CC
cord-006702-ekf6mja9	250	3	elevated	elevate	VBD
cord-006702-ekf6mja9	250	4	glomerular	glomerular	JJ
cord-006702-ekf6mja9	250	5	filtration	filtration	NN
cord-006702-ekf6mja9	250	6	showed	show	VBD
cord-006702-ekf6mja9	250	7	strong	strong	JJ
cord-006702-ekf6mja9	250	8	positive	positive	JJ
cord-006702-ekf6mja9	250	9	correlation	correlation	NN
cord-006702-ekf6mja9	250	10	with	with	IN
cord-006702-ekf6mja9	250	11	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	250	12	,	,	,
cord-006702-ekf6mja9	250	13	however	however	RB
cord-006702-ekf6mja9	250	14	,	,	,
cord-006702-ekf6mja9	250	15	age	age	NN
cord-006702-ekf6mja9	250	16	,	,	,
cord-006702-ekf6mja9	250	17	low	low	JJ
cord-006702-ekf6mja9	250	18	socio	socio	JJ
cord-006702-ekf6mja9	250	19	economic	economic	JJ
cord-006702-ekf6mja9	250	20	status	status	NN
cord-006702-ekf6mja9	250	21	,	,	,
cord-006702-ekf6mja9	250	22	number	number	NN
cord-006702-ekf6mja9	250	23	of	of	IN
cord-006702-ekf6mja9	250	24	siblings	sibling	NNS
cord-006702-ekf6mja9	250	25	with	with	IN
cord-006702-ekf6mja9	250	26	SCA	SCA	NNP
cord-006702-ekf6mja9	250	27	,	,	,
cord-006702-ekf6mja9	250	28	did	do	VBD
cord-006702-ekf6mja9	250	29	not	not	RB
cord-006702-ekf6mja9	250	30	.	.	.
cord-006702-ekf6mja9	251	1	Glomerular	glomerular	JJ
cord-006702-ekf6mja9	251	2	filtration	filtration	NN
cord-006702-ekf6mja9	251	3	rate	rate	NN
cord-006702-ekf6mja9	251	4	was	be	VBD
cord-006702-ekf6mja9	251	5	higher	high	JJR
cord-006702-ekf6mja9	251	6	in	in	IN
cord-006702-ekf6mja9	251	7	subjects	subject	NNS
cord-006702-ekf6mja9	251	8	with	with	IN
cord-006702-ekf6mja9	251	9	SCA	SCA	NNP
cord-006702-ekf6mja9	251	10	than	than	IN
cord-006702-ekf6mja9	251	11	controls	control	NNS
cord-006702-ekf6mja9	251	12	and	and	CC
cord-006702-ekf6mja9	251	13	as	as	RB
cord-006702-ekf6mja9	251	14	well	well	RB
cord-006702-ekf6mja9	251	15	in	in	IN
cord-006702-ekf6mja9	251	16	those	those	DT
cord-006702-ekf6mja9	251	17	with	with	IN
cord-006702-ekf6mja9	251	18	microalbuminuria	microalbuminuria	NNS
cord-006702-ekf6mja9	251	19	compared	compare	VBN
cord-006702-ekf6mja9	251	20	to	to	IN
cord-006702-ekf6mja9	251	21	those	those	DT
cord-006702-ekf6mja9	251	22	without	without	IN
cord-006702-ekf6mja9	251	23	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	251	24	(	(	-LRB-
cord-006702-ekf6mja9	251	25	p<0.01	p<0.01	NNP
cord-006702-ekf6mja9	251	26	)	)	-RRB-
cord-006702-ekf6mja9	251	27	.	.	.
cord-006702-ekf6mja9	252	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	252	2	:	:	:
cord-006702-ekf6mja9	253	1	The	the	DT
cord-006702-ekf6mja9	253	2	prevalence	prevalence	NN
cord-006702-ekf6mja9	253	3	of	of	IN
cord-006702-ekf6mja9	253	4	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	253	5	in	in	IN
cord-006702-ekf6mja9	253	6	children	child	NNS
cord-006702-ekf6mja9	253	7	with	with	IN
cord-006702-ekf6mja9	253	8	SCA	SCA	NNP
cord-006702-ekf6mja9	253	9	in	in	IN
cord-006702-ekf6mja9	253	10	this	this	DT
cord-006702-ekf6mja9	253	11	study	study	NN
cord-006702-ekf6mja9	253	12	is	be	VBZ
cord-006702-ekf6mja9	253	13	high	high	JJ
cord-006702-ekf6mja9	253	14	.	.	.
cord-006702-ekf6mja9	254	1	The	the	DT
cord-006702-ekf6mja9	254	2	mean	mean	JJ
cord-006702-ekf6mja9	254	3	glomerular	glomerular	JJ
cord-006702-ekf6mja9	254	4	filtration	filtration	NN
cord-006702-ekf6mja9	254	5	rate	rate	NN
cord-006702-ekf6mja9	254	6	is	be	VBZ
cord-006702-ekf6mja9	254	7	particularly	particularly	RB
cord-006702-ekf6mja9	254	8	higher	high	JJR
cord-006702-ekf6mja9	254	9	in	in	IN
cord-006702-ekf6mja9	254	10	those	those	DT
cord-006702-ekf6mja9	254	11	with	with	IN
cord-006702-ekf6mja9	254	12	microalbuminuria	microalbuminuria	NNS
cord-006702-ekf6mja9	254	13	compared	compare	VBN
cord-006702-ekf6mja9	254	14	with	with	IN
cord-006702-ekf6mja9	254	15	those	those	DT
cord-006702-ekf6mja9	254	16	without	without	IN
cord-006702-ekf6mja9	254	17	.	.	.
cord-006702-ekf6mja9	255	1	This	this	DT
cord-006702-ekf6mja9	255	2	finding	finding	NN
cord-006702-ekf6mja9	255	3	underscores	underscore	VBZ
cord-006702-ekf6mja9	255	4	the	the	DT
cord-006702-ekf6mja9	255	5	need	need	NN
cord-006702-ekf6mja9	255	6	for	for	IN
cord-006702-ekf6mja9	255	7	concerted	concerted	JJ
cord-006702-ekf6mja9	255	8	effort	effort	NN
cord-006702-ekf6mja9	255	9	at	at	IN
cord-006702-ekf6mja9	255	10	routine	routine	JJ
cord-006702-ekf6mja9	255	11	screening	screening	NN
cord-006702-ekf6mja9	255	12	of	of	IN
cord-006702-ekf6mja9	255	13	SCA	SCA	NNP
cord-006702-ekf6mja9	255	14	children	child	NNS
cord-006702-ekf6mja9	255	15	for	for	IN
cord-006702-ekf6mja9	255	16	microalbuminuria	microalbuminuria	NNP
cord-006702-ekf6mja9	255	17	for	for	IN
cord-006702-ekf6mja9	255	18	the	the	DT
cord-006702-ekf6mja9	255	19	purpose	purpose	NN
cord-006702-ekf6mja9	255	20	of	of	IN
cord-006702-ekf6mja9	255	21	earlier	early	JJR
cord-006702-ekf6mja9	255	22	detection	detection	NN
cord-006702-ekf6mja9	255	23	of	of	IN
cord-006702-ekf6mja9	255	24	sickle	sickle	NN
cord-006702-ekf6mja9	255	25	cell	cell	NN
cord-006702-ekf6mja9	255	26	nephropathy	nephropathy	NN
cord-006702-ekf6mja9	255	27	and	and	CC
cord-006702-ekf6mja9	255	28	appropriate	appropriate	JJ
cord-006702-ekf6mja9	255	29	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	255	30	measure	measure	NN
cord-006702-ekf6mja9	255	31	.	.	.
cord-006702-ekf6mja9	256	1	S10	S10	NNP
cord-006702-ekf6mja9	256	2	-Global	-Global	VBZ
cord-006702-ekf6mja9	256	3	perspectives	perspective	NNS
cord-006702-ekf6mja9	256	4	on	on	IN
cord-006702-ekf6mja9	256	5	registries	registry	NNS
cord-006702-ekf6mja9	256	6	FP	FP	NNP
cord-006702-ekf6mja9	256	7	-	-	HYPH
cord-006702-ekf6mja9	256	8	S10	S10	NNP
cord-006702-ekf6mja9	256	9	-	-	HYPH
cord-006702-ekf6mja9	256	10	1	1	CD
cord-006702-ekf6mja9	256	11	Congenital	congenital	JJ
cord-006702-ekf6mja9	256	12	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	256	13	syndrome	syndrome	NN
cord-006702-ekf6mja9	256	14	of	of	IN
cord-006702-ekf6mja9	256	15	the	the	DT
cord-006702-ekf6mja9	256	16	Finnish	finnish	JJ
cord-006702-ekf6mja9	256	17	type	type	NN
cord-006702-ekf6mja9	256	18	,	,	,
cord-006702-ekf6mja9	256	19	ESPN	ESPN	NNP
cord-006702-ekf6mja9	256	20	/	/	SYM
cord-006702-ekf6mja9	256	21	ERA	ERA	NNP
cord-006702-ekf6mja9	256	22	-	-	HYPH
cord-006702-ekf6mja9	256	23	EDTA	EDTA	NNP
cord-006702-ekf6mja9	256	24	Registry	Registry	NNP
cord-006702-ekf6mja9	256	25	data	datum	NNS
cord-006702-ekf6mja9	256	26	T.	T.	NNP
cord-006702-ekf6mja9	256	27	Holtta	Holtta	NNP
cord-006702-ekf6mja9	256	28	(	(	-LRB-
cord-006702-ekf6mja9	256	29	1	1	CD
cord-006702-ekf6mja9	256	30	)	)	-RRB-
cord-006702-ekf6mja9	256	31	,	,	,
cord-006702-ekf6mja9	256	32	M.	M.	NNP
cord-006702-ekf6mja9	256	33	Bonthuis	Bonthuis	NNP
cord-006702-ekf6mja9	256	34	(	(	-LRB-
cord-006702-ekf6mja9	256	35	2	2	CD
cord-006702-ekf6mja9	256	36	)	)	-RRB-
cord-006702-ekf6mja9	256	37	,	,	,
cord-006702-ekf6mja9	256	38	K.	K.	NNP
cord-006702-ekf6mja9	256	39	Jager	Jager	NNP
cord-006702-ekf6mja9	256	40	(	(	-LRB-
cord-006702-ekf6mja9	256	41	2	2	CD
cord-006702-ekf6mja9	256	42	)	)	-RRB-
cord-006702-ekf6mja9	256	43	,	,	,
cord-006702-ekf6mja9	256	44	J.	J.	NNP
cord-006702-ekf6mja9	256	45	Groothoff	Groothoff	NNP
cord-006702-ekf6mja9	256	46	(	(	-LRB-
cord-006702-ekf6mja9	256	47	,	,	,
cord-006702-ekf6mja9	256	48	and	and	CC
cord-006702-ekf6mja9	256	49	most	most	JJS
cord-006702-ekf6mja9	256	50	of	of	IN
cord-006702-ekf6mja9	256	51	recipients	recipient	NNS
cord-006702-ekf6mja9	256	52	were	be	VBD
cord-006702-ekf6mja9	256	53	male	male	JJ
cord-006702-ekf6mja9	256	54	(	(	-LRB-
cord-006702-ekf6mja9	256	55	55.5	55.5	CD
cord-006702-ekf6mja9	256	56	%	%	NN
cord-006702-ekf6mja9	256	57	)	)	-RRB-
cord-006702-ekf6mja9	256	58	.	.	.
cord-006702-ekf6mja9	257	1	The	the	DT
cord-006702-ekf6mja9	257	2	most	most	RBS
cord-006702-ekf6mja9	257	3	common	common	JJ
cord-006702-ekf6mja9	257	4	underlying	underlying	JJ
cord-006702-ekf6mja9	257	5	renal	renal	JJ
cord-006702-ekf6mja9	257	6	etiologies	etiology	NNS
cord-006702-ekf6mja9	257	7	were	be	VBD
cord-006702-ekf6mja9	257	8	congenital	congenital	JJ
cord-006702-ekf6mja9	257	9	anomalies	anomaly	NNS
cord-006702-ekf6mja9	257	10	of	of	IN
cord-006702-ekf6mja9	257	11	the	the	DT
cord-006702-ekf6mja9	257	12	kidney	kidney	NN
cord-006702-ekf6mja9	257	13	and	and	CC
cord-006702-ekf6mja9	257	14	urinary	urinary	JJ
cord-006702-ekf6mja9	257	15	tract	tract	NN
cord-006702-ekf6mja9	257	16	(	(	-LRB-
cord-006702-ekf6mja9	257	17	46.7	46.7	CD
cord-006702-ekf6mja9	257	18	%	%	NN
cord-006702-ekf6mja9	257	19	)	)	-RRB-
cord-006702-ekf6mja9	257	20	and	and	CC
cord-006702-ekf6mja9	257	21	glomerulopathy	glomerulopathy	NNP
cord-006702-ekf6mja9	257	22	(	(	-LRB-
cord-006702-ekf6mja9	257	23	33.5	33.5	CD
cord-006702-ekf6mja9	257	24	%	%	NN
cord-006702-ekf6mja9	257	25	)	)	-RRB-
cord-006702-ekf6mja9	257	26	.	.	.
cord-006702-ekf6mja9	258	1	According	accord	VBG
cord-006702-ekf6mja9	258	2	to	to	IN
cord-006702-ekf6mja9	258	3	donor	donor	NN
cord-006702-ekf6mja9	258	4	source	source	NN
cord-006702-ekf6mja9	258	5	,	,	,
cord-006702-ekf6mja9	258	6	1566	1566	CD
cord-006702-ekf6mja9	258	7	(	(	-LRB-
cord-006702-ekf6mja9	258	8	69.3	69.3	CD
cord-006702-ekf6mja9	258	9	%	%	NN
cord-006702-ekf6mja9	258	10	)	)	-RRB-
cord-006702-ekf6mja9	258	11	of	of	IN
cord-006702-ekf6mja9	258	12	transplants	transplant	NNS
cord-006702-ekf6mja9	258	13	were	be	VBD
cord-006702-ekf6mja9	258	14	performed	perform	VBN
cord-006702-ekf6mja9	258	15	with	with	IN
cord-006702-ekf6mja9	258	16	deceased	deceased	JJ
cord-006702-ekf6mja9	258	17	donors	donor	NNS
cord-006702-ekf6mja9	258	18	(	(	-LRB-
cord-006702-ekf6mja9	258	19	DD	DD	NNP
cord-006702-ekf6mja9	258	20	)	)	-RRB-
cord-006702-ekf6mja9	258	21	.	.	.
cord-006702-ekf6mja9	259	1	Graft	graft	NN
cord-006702-ekf6mja9	259	2	survival	survival	NN
cord-006702-ekf6mja9	259	3	rates	rate	NNS
cord-006702-ekf6mja9	259	4	according	accord	VBG
cord-006702-ekf6mja9	259	5	to	to	IN
cord-006702-ekf6mja9	259	6	donor	donor	NN
cord-006702-ekf6mja9	259	7	source	source	NN
cord-006702-ekf6mja9	259	8	at	at	IN
cord-006702-ekf6mja9	259	9	12	12	CD
cord-006702-ekf6mja9	259	10	,	,	,
cord-006702-ekf6mja9	259	11	60	60	CD
cord-006702-ekf6mja9	259	12	,	,	,
cord-006702-ekf6mja9	259	13	and	and	CC
cord-006702-ekf6mja9	259	14	120	120	CD
cord-006702-ekf6mja9	259	15	months	month	NNS
cord-006702-ekf6mja9	259	16	were	be	VBD
cord-006702-ekf6mja9	259	17	94	94	CD
cord-006702-ekf6mja9	259	18	%	%	NN
cord-006702-ekf6mja9	259	19	,	,	,
cord-006702-ekf6mja9	259	20	85	85	CD
cord-006702-ekf6mja9	259	21	%	%	NN
cord-006702-ekf6mja9	259	22	,	,	,
cord-006702-ekf6mja9	259	23	and	and	CC
cord-006702-ekf6mja9	259	24	72	72	CD
cord-006702-ekf6mja9	259	25	%	%	NN
cord-006702-ekf6mja9	259	26	for	for	IN
cord-006702-ekf6mja9	259	27	living	live	VBG
cord-006702-ekf6mja9	259	28	donor	donor	NN
cord-006702-ekf6mja9	259	29	(	(	-LRB-
cord-006702-ekf6mja9	259	30	LD	LD	NNP
cord-006702-ekf6mja9	259	31	)	)	-RRB-
cord-006702-ekf6mja9	259	32	and	and	CC
cord-006702-ekf6mja9	259	33	91	91	CD
cord-006702-ekf6mja9	259	34	%	%	NN
cord-006702-ekf6mja9	259	35	,	,	,
cord-006702-ekf6mja9	259	36	76	76	CD
cord-006702-ekf6mja9	259	37	%	%	NN
cord-006702-ekf6mja9	259	38	,	,	,
cord-006702-ekf6mja9	259	39	and	and	CC
cord-006702-ekf6mja9	259	40	62	62	CD
cord-006702-ekf6mja9	259	41	%	%	NN
cord-006702-ekf6mja9	259	42	for	for	IN
cord-006702-ekf6mja9	259	43	DD	DD	NNP
cord-006702-ekf6mja9	259	44	,	,	,
cord-006702-ekf6mja9	259	45	respectively	respectively	RB
cord-006702-ekf6mja9	259	46	(	(	-LRB-
cord-006702-ekf6mja9	259	47	log	log	NN
cord-006702-ekf6mja9	259	48	rank	rank	NN
cord-006702-ekf6mja9	259	49	test	test	NN
cord-006702-ekf6mja9	259	50	,	,	,
cord-006702-ekf6mja9	259	51	P	p	NN
cord-006702-ekf6mja9	259	52	<	<	XX
cord-006702-ekf6mja9	259	53	.01	.01	NFP
cord-006702-ekf6mja9	259	54	)	)	-RRB-
cord-006702-ekf6mja9	259	55	.	.	.
cord-006702-ekf6mja9	260	1	Graft	graft	NN
cord-006702-ekf6mja9	260	2	losses	loss	NNS
cord-006702-ekf6mja9	260	3	(	(	-LRB-
cord-006702-ekf6mja9	260	4	20	20	CD
cord-006702-ekf6mja9	260	5	%	%	NN
cord-006702-ekf6mja9	260	6	)	)	-RRB-
cord-006702-ekf6mja9	260	7	were	be	VBD
cord-006702-ekf6mja9	260	8	most	most	RBS
cord-006702-ekf6mja9	260	9	frequently	frequently	RB
cord-006702-ekf6mja9	260	10	caused	cause	VBN
cord-006702-ekf6mja9	260	11	by	by	IN
cord-006702-ekf6mja9	260	12	vascular	vascular	JJ
cord-006702-ekf6mja9	260	13	thrombosis	thrombosis	NN
cord-006702-ekf6mja9	260	14	,	,	,
cord-006702-ekf6mja9	260	15	chronic	chronic	JJ
cord-006702-ekf6mja9	260	16	allograft	allograft	NN
cord-006702-ekf6mja9	260	17	nephropathy	nephropathy	NN
cord-006702-ekf6mja9	260	18	,	,	,
cord-006702-ekf6mja9	260	19	death	death	NN
cord-006702-ekf6mja9	260	20	with	with	IN
cord-006702-ekf6mja9	260	21	functioning	function	VBG
cord-006702-ekf6mja9	260	22	kidney	kidney	NN
cord-006702-ekf6mja9	260	23	,	,	,
cord-006702-ekf6mja9	260	24	acute	acute	JJ
cord-006702-ekf6mja9	260	25	rejection	rejection	NN
cord-006702-ekf6mja9	260	26	,	,	,
cord-006702-ekf6mja9	260	27	and	and	CC
cord-006702-ekf6mja9	260	28	recurrent	recurrent	JJ
cord-006702-ekf6mja9	260	29	renal	renal	JJ
cord-006702-ekf6mja9	260	30	disease	disease	NN
cord-006702-ekf6mja9	260	31	.	.	.
cord-006702-ekf6mja9	261	1	Recipients	recipient	NNS
cord-006702-ekf6mja9	261	2	of	of	IN
cord-006702-ekf6mja9	261	3	DD	DD	NNP
cord-006702-ekf6mja9	261	4	had	have	VBD
cord-006702-ekf6mja9	261	5	1.54	1.54	CD
cord-006702-ekf6mja9	261	6	(	(	-LRB-
cord-006702-ekf6mja9	261	7	95	95	CD
cord-006702-ekf6mja9	261	8	%	%	NN
cord-006702-ekf6mja9	261	9	confidence	confidence	NN
cord-006702-ekf6mja9	261	10	interval:1.04	interval:1.04	NN
cord-006702-ekf6mja9	261	11	-	-	HYPH
cord-006702-ekf6mja9	261	12	2.30	2.30	CD
cord-006702-ekf6mja9	261	13	)	)	-RRB-
cord-006702-ekf6mja9	261	14	times	time	NNS
cord-006702-ekf6mja9	261	15	the	the	DT
cord-006702-ekf6mja9	261	16	hazard	hazard	NN
cord-006702-ekf6mja9	261	17	of	of	IN
cord-006702-ekf6mja9	261	18	graft	graft	NN
cord-006702-ekf6mja9	261	19	loss	loss	NN
cord-006702-ekf6mja9	261	20	compared	compare	VBN
cord-006702-ekf6mja9	261	21	with	with	IN
cord-006702-ekf6mja9	261	22	those	those	DT
cord-006702-ekf6mja9	261	23	of	of	IN
cord-006702-ekf6mja9	261	24	LD	LD	NNP
cord-006702-ekf6mja9	261	25	(	(	-LRB-
cord-006702-ekf6mja9	261	26	P	p	NN
cord-006702-ekf6mja9	261	27	<	<	XX
cord-006702-ekf6mja9	261	28	0.05	0.05	CD
cord-006702-ekf6mja9	261	29	)	)	-RRB-
cord-006702-ekf6mja9	261	30	.	.	.
cord-006702-ekf6mja9	262	1	Patient	patient	JJ
cord-006702-ekf6mja9	262	2	survival	survival	NN
cord-006702-ekf6mja9	262	3	rates	rate	NNS
cord-006702-ekf6mja9	262	4	at	at	IN
cord-006702-ekf6mja9	262	5	1	1	CD
cord-006702-ekf6mja9	262	6	,	,	,
cord-006702-ekf6mja9	262	7	5	5	CD
cord-006702-ekf6mja9	262	8	,	,	,
cord-006702-ekf6mja9	262	9	and	and	CC
cord-006702-ekf6mja9	262	10	10	10	CD
cord-006702-ekf6mja9	262	11	years	year	NNS
cord-006702-ekf6mja9	262	12	were	be	VBD
cord-006702-ekf6mja9	262	13	98	98	CD
cord-006702-ekf6mja9	262	14	%	%	NN
cord-006702-ekf6mja9	262	15	,	,	,
cord-006702-ekf6mja9	262	16	95	95	CD
cord-006702-ekf6mja9	262	17	and	and	CC
cord-006702-ekf6mja9	262	18	92	92	CD
cord-006702-ekf6mja9	262	19	%	%	NN
cord-006702-ekf6mja9	262	20	for	for	IN
cord-006702-ekf6mja9	262	21	LD	LD	NNP
cord-006702-ekf6mja9	262	22	and	and	CC
cord-006702-ekf6mja9	262	23	97	97	CD
cord-006702-ekf6mja9	262	24	%	%	NN
cord-006702-ekf6mja9	262	25	,	,	,
cord-006702-ekf6mja9	262	26	93	93	CD
cord-006702-ekf6mja9	262	27	%	%	NN
cord-006702-ekf6mja9	262	28	,	,	,
cord-006702-ekf6mja9	262	29	and	and	CC
cord-006702-ekf6mja9	262	30	97	97	CD
cord-006702-ekf6mja9	262	31	%	%	NN
cord-006702-ekf6mja9	262	32	for	for	IN
cord-006702-ekf6mja9	262	33	DD	DD	NNP
cord-006702-ekf6mja9	262	34	,	,	,
cord-006702-ekf6mja9	262	35	respectively	respectively	RB
cord-006702-ekf6mja9	262	36	.	.	.
cord-006702-ekf6mja9	263	1	The	the	DT
cord-006702-ekf6mja9	263	2	mortality	mortality	NN
cord-006702-ekf6mja9	263	3	rate	rate	NN
cord-006702-ekf6mja9	263	4	was	be	VBD
cord-006702-ekf6mja9	263	5	5.6	5.6	CD
cord-006702-ekf6mja9	263	6	%	%	NN
cord-006702-ekf6mja9	263	7	,	,	,
cord-006702-ekf6mja9	263	8	mainly	mainly	RB
cord-006702-ekf6mja9	263	9	as	as	IN
cord-006702-ekf6mja9	263	10	the	the	DT
cord-006702-ekf6mja9	263	11	result	result	NN
cord-006702-ekf6mja9	263	12	of	of	IN
cord-006702-ekf6mja9	263	13	infection	infection	NN
cord-006702-ekf6mja9	263	14	and	and	CC
cord-006702-ekf6mja9	263	15	cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	263	16	disease	disease	NN
cord-006702-ekf6mja9	263	17	.	.	.
cord-006702-ekf6mja9	264	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	264	2	:	:	:
cord-006702-ekf6mja9	265	1	The	the	DT
cord-006702-ekf6mja9	265	2	results	result	NNS
cord-006702-ekf6mja9	265	3	of	of	IN
cord-006702-ekf6mja9	265	4	this	this	DT
cord-006702-ekf6mja9	265	5	collaborative	collaborative	JJ
cord-006702-ekf6mja9	265	6	pediatric	pediatric	JJ
cord-006702-ekf6mja9	265	7	transplant	transplant	NN
cord-006702-ekf6mja9	265	8	study	study	NN
cord-006702-ekf6mja9	265	9	are	be	VBP
cord-006702-ekf6mja9	265	10	comparable	comparable	JJ
cord-006702-ekf6mja9	265	11	to	to	IN
cord-006702-ekf6mja9	265	12	international	international	JJ
cord-006702-ekf6mja9	265	13	registries	registry	NNS
cord-006702-ekf6mja9	265	14	.	.	.
cord-006702-ekf6mja9	266	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	266	2	effort	effort	NN
cord-006702-ekf6mja9	266	3	has	have	VBZ
cord-006702-ekf6mja9	266	4	been	be	VBN
cord-006702-ekf6mja9	266	5	able	able	JJ
cord-006702-ekf6mja9	266	6	to	to	TO
cord-006702-ekf6mja9	266	7	maintain	maintain	VB
cord-006702-ekf6mja9	266	8	an	an	DT
cord-006702-ekf6mja9	266	9	exchange	exchange	NN
cord-006702-ekf6mja9	266	10	of	of	IN
cord-006702-ekf6mja9	266	11	information	information	NN
cord-006702-ekf6mja9	266	12	,	,	,
cord-006702-ekf6mja9	266	13	both	both	CC
cord-006702-ekf6mja9	266	14	among	among	IN
cord-006702-ekf6mja9	266	15	the	the	DT
cord-006702-ekf6mja9	266	16	participating	participate	VBG
cord-006702-ekf6mja9	266	17	centers	center	NNS
cord-006702-ekf6mja9	266	18	and	and	CC
cord-006702-ekf6mja9	266	19	with	with	IN
cord-006702-ekf6mja9	266	20	other	other	JJ
cord-006702-ekf6mja9	266	21	international	international	JJ
cord-006702-ekf6mja9	266	22	registries	registry	NNS
cord-006702-ekf6mja9	266	23	.	.	.
cord-006702-ekf6mja9	267	1	FP	FP	NNP
cord-006702-ekf6mja9	267	2	-	-	HYPH
cord-006702-ekf6mja9	267	3	S10	S10	NNP
cord-006702-ekf6mja9	267	4	-	-	HYPH
cord-006702-ekf6mja9	267	5	3	3	CD
cord-006702-ekf6mja9	267	6	Turkish	turkish	JJ
cord-006702-ekf6mja9	267	7	Atypical	atypical	JJ
cord-006702-ekf6mja9	267	8	Hemolytic	hemolytic	JJ
cord-006702-ekf6mja9	267	9	Uremic	Uremic	NNP
cord-006702-ekf6mja9	267	10	Syndrome	Syndrome	NNP
cord-006702-ekf6mja9	267	11	Registry	registry	NN
cord-006702-ekf6mja9	267	12	:	:	:
cord-006702-ekf6mja9	267	13	Evaluation	evaluation	NN
cord-006702-ekf6mja9	267	14	of	of	IN
cord-006702-ekf6mja9	267	15	long	long	JJ
cord-006702-ekf6mja9	267	16	term	term	NN
cord-006702-ekf6mja9	267	17	prognosis	prognosis	NN
cord-006702-ekf6mja9	267	18	A.	a.	NN
cord-006702-ekf6mja9	267	19	Soylu	Soylu	NNP
cord-006702-ekf6mja9	267	20	(	(	-LRB-
cord-006702-ekf6mja9	267	21	1	1	CD
cord-006702-ekf6mja9	267	22	)	)	-RRB-
cord-006702-ekf6mja9	267	23	,	,	,
cord-006702-ekf6mja9	267	24	K.	K.	NNP
cord-006702-ekf6mja9	267	25	GÜllero?lu	GÜllero?lu	NNP
cord-006702-ekf6mja9	267	26	(	(	-LRB-
cord-006702-ekf6mja9	267	27	2	2	CD
cord-006702-ekf6mja9	267	28	)	)	-RRB-
cord-006702-ekf6mja9	267	29	,	,	,
cord-006702-ekf6mja9	267	30	İ.	İ.	NNP
cord-006702-ekf6mja9	267	31	Gökçe	Gökçe	NNP
cord-006702-ekf6mja9	267	32	(	(	-LRB-
cord-006702-ekf6mja9	267	33	3	3	CD
cord-006702-ekf6mja9	267	34	)	)	-RRB-
cord-006702-ekf6mja9	267	35	,	,	,
cord-006702-ekf6mja9	267	36	G.	G.	NNP
cord-006702-ekf6mja9	267	37	Parmaks?z	Parmaks?z	NNS
cord-006702-ekf6mja9	267	38	(	(	-LRB-
cord-006702-ekf6mja9	267	39	4	4	CD
cord-006702-ekf6mja9	267	40	)	)	-RRB-
cord-006702-ekf6mja9	267	41	,	,	,
cord-006702-ekf6mja9	267	42	H.	H.	NNP
cord-006702-ekf6mja9	267	43	Evrengül	Evrengül	NNP
cord-006702-ekf6mja9	267	44	(	(	-LRB-
cord-006702-ekf6mja9	267	45	5	5	CD
cord-006702-ekf6mja9	267	46	)	)	-RRB-
cord-006702-ekf6mja9	267	47	,	,	,
cord-006702-ekf6mja9	267	48	G.	G.	NNP
cord-006702-ekf6mja9	267	49	Kaya	Kaya	NNP
cord-006702-ekf6mja9	267	50	Aksoy	Aksoy	NNP
cord-006702-ekf6mja9	267	51	(	(	-LRB-
cord-006702-ekf6mja9	267	52	6	6	CD
cord-006702-ekf6mja9	267	53	)	)	-RRB-
cord-006702-ekf6mja9	267	54	,	,	,
cord-006702-ekf6mja9	267	55	M.	M.	NNP
cord-006702-ekf6mja9	267	56	Hayran	Hayran	NNP
cord-006702-ekf6mja9	268	1	(	(	-LRB-
cord-006702-ekf6mja9	268	2	7	7	CD
cord-006702-ekf6mja9	268	3	ESRD	ESRD	NNP
cord-006702-ekf6mja9	268	4	risk	risk	NN
cord-006702-ekf6mja9	268	5	was	be	VBD
cord-006702-ekf6mja9	268	6	increased	increase	VBN
cord-006702-ekf6mja9	268	7	in	in	IN
cord-006702-ekf6mja9	268	8	children	child	NNS
cord-006702-ekf6mja9	268	9	>	>	XX
cord-006702-ekf6mja9	268	10	2	2	CD
cord-006702-ekf6mja9	268	11	years	year	NNS
cord-006702-ekf6mja9	268	12	of	of	IN
cord-006702-ekf6mja9	268	13	age	age	NN
cord-006702-ekf6mja9	268	14	at	at	IN
cord-006702-ekf6mja9	268	15	onset	onset	NN
cord-006702-ekf6mja9	268	16	,	,	,
cord-006702-ekf6mja9	268	17	while	while	IN
cord-006702-ekf6mja9	268	18	chronic	chronic	JJ
cord-006702-ekf6mja9	268	19	renal	renal	JJ
cord-006702-ekf6mja9	268	20	disease	disease	NN
cord-006702-ekf6mja9	268	21	was	be	VBD
cord-006702-ekf6mja9	268	22	higher	high	JJR
cord-006702-ekf6mja9	268	23	in	in	IN
cord-006702-ekf6mja9	268	24	the	the	DT
cord-006702-ekf6mja9	268	25	presence	presence	NN
cord-006702-ekf6mja9	268	26	of	of	IN
cord-006702-ekf6mja9	268	27	extrarenal	extrarenal	JJ
cord-006702-ekf6mja9	268	28	organ	organ	NN
cord-006702-ekf6mja9	268	29	involvement	involvement	NN
cord-006702-ekf6mja9	268	30	,	,	,
cord-006702-ekf6mja9	268	31	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	268	32	range	range	NN
cord-006702-ekf6mja9	268	33	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	268	34	at	at	IN
cord-006702-ekf6mja9	268	35	onset	onset	NN
cord-006702-ekf6mja9	268	36	and	and	CC
cord-006702-ekf6mja9	268	37	CFH	CFH	NNP
cord-006702-ekf6mja9	268	38	mutation	mutation	NN
cord-006702-ekf6mja9	268	39	.	.	.
cord-006702-ekf6mja9	269	1	Presence	presence	NN
cord-006702-ekf6mja9	269	2	of	of	IN
cord-006702-ekf6mja9	269	3	hypocomplementemia	hypocomplementemia	NNP
cord-006702-ekf6mja9	269	4	was	be	VBD
cord-006702-ekf6mja9	269	5	associated	associate	VBN
cord-006702-ekf6mja9	269	6	with	with	IN
cord-006702-ekf6mja9	269	7	lower	low	JJR
cord-006702-ekf6mja9	269	8	risk	risk	NN
cord-006702-ekf6mja9	269	9	of	of	IN
cord-006702-ekf6mja9	269	10	chronic	chronic	JJ
cord-006702-ekf6mja9	269	11	renal	renal	JJ
cord-006702-ekf6mja9	269	12	disease	disease	NN
cord-006702-ekf6mja9	269	13	.	.	.
cord-006702-ekf6mja9	270	1	Interestingly	interestingly	RB
cord-006702-ekf6mja9	270	2	,	,	,
cord-006702-ekf6mja9	270	3	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	270	4	,	,	,
cord-006702-ekf6mja9	270	5	hypertension	hypertension	NN
cord-006702-ekf6mja9	270	6	and	and	CC
cord-006702-ekf6mja9	270	7	overall	overall	JJ
cord-006702-ekf6mja9	270	8	chronic	chronic	JJ
cord-006702-ekf6mja9	270	9	renal	renal	JJ
cord-006702-ekf6mja9	270	10	disease	disease	NN
cord-006702-ekf6mja9	270	11	rate	rate	NN
cord-006702-ekf6mja9	270	12	was	be	VBD
cord-006702-ekf6mja9	270	13	higher	high	JJR
cord-006702-ekf6mja9	270	14	in	in	IN
cord-006702-ekf6mja9	270	15	those	those	DT
cord-006702-ekf6mja9	270	16	treated	treat	VBN
cord-006702-ekf6mja9	270	17	with	with	IN
cord-006702-ekf6mja9	270	18	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	270	19	.	.	.
cord-006702-ekf6mja9	271	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	271	2	:	:	:
cord-006702-ekf6mja9	272	1	More	More	JJR
cord-006702-ekf6mja9	272	2	than	than	IN
cord-006702-ekf6mja9	272	3	half	half	NN
cord-006702-ekf6mja9	272	4	of	of	IN
cord-006702-ekf6mja9	272	5	the	the	DT
cord-006702-ekf6mja9	272	6	children	child	NNS
cord-006702-ekf6mja9	272	7	with	with	IN
cord-006702-ekf6mja9	272	8	aHUS	ahus	DT
cord-006702-ekf6mja9	272	9	developed	develop	VBN
cord-006702-ekf6mja9	272	10	chronic	chronic	JJ
cord-006702-ekf6mja9	272	11	renal	renal	JJ
cord-006702-ekf6mja9	272	12	disease	disease	NN
cord-006702-ekf6mja9	272	13	.	.	.
cord-006702-ekf6mja9	273	1	Age	age	NN
cord-006702-ekf6mja9	273	2	over	over	IN
cord-006702-ekf6mja9	273	3	2	2	CD
cord-006702-ekf6mja9	273	4	years	year	NNS
cord-006702-ekf6mja9	273	5	at	at	IN
cord-006702-ekf6mja9	273	6	onset	onset	NN
cord-006702-ekf6mja9	273	7	,	,	,
cord-006702-ekf6mja9	273	8	extrarenal	extrarenal	JJ
cord-006702-ekf6mja9	273	9	organ	organ	NN
cord-006702-ekf6mja9	273	10	involvement	involvement	NN
cord-006702-ekf6mja9	273	11	,	,	,
cord-006702-ekf6mja9	273	12	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	273	13	range	range	NN
cord-006702-ekf6mja9	273	14	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	273	15	and	and	CC
cord-006702-ekf6mja9	273	16	CFH	CFH	NNP
cord-006702-ekf6mja9	273	17	mutation	mutation	NN
cord-006702-ekf6mja9	273	18	were	be	VBD
cord-006702-ekf6mja9	273	19	associated	associate	VBN
cord-006702-ekf6mja9	273	20	with	with	IN
cord-006702-ekf6mja9	273	21	poor	poor	JJ
cord-006702-ekf6mja9	273	22	renal	renal	JJ
cord-006702-ekf6mja9	273	23	prognosis	prognosis	NN
cord-006702-ekf6mja9	273	24	.	.	.
cord-006702-ekf6mja9	274	1	FP	FP	NNP
cord-006702-ekf6mja9	274	2	-	-	HYPH
cord-006702-ekf6mja9	274	3	S11	S11	NNP
cord-006702-ekf6mja9	274	4	-	-	HYPH
cord-006702-ekf6mja9	274	5	1	1	CD
cord-006702-ekf6mja9	274	6	Serum	serum	NN
cord-006702-ekf6mja9	274	7	fractalkine	fractalkine	NN
cord-006702-ekf6mja9	274	8	(	(	-LRB-
cord-006702-ekf6mja9	274	9	CX3CL1	cx3cl1	NN
cord-006702-ekf6mja9	274	10	)	)	-RRB-
cord-006702-ekf6mja9	274	11	is	be	VBZ
cord-006702-ekf6mja9	274	12	associated	associate	VBN
cord-006702-ekf6mja9	274	13	with	with	IN
cord-006702-ekf6mja9	274	14	abnormal	abnormal	JJ
cord-006702-ekf6mja9	274	15	carotid	carotid	JJ
cord-006702-ekf6mja9	274	16	and	and	CC
cord-006702-ekf6mja9	274	17	femoral	femoral	JJ
cord-006702-ekf6mja9	274	18	intimal	intimal	JJ
cord-006702-ekf6mja9	274	19	medial	medial	JJ
cord-006702-ekf6mja9	274	20	thickness	thickness	NN
cord-006702-ekf6mja9	274	21	in	in	IN
cord-006702-ekf6mja9	274	22	pediatric	pediatric	JJ
cord-006702-ekf6mja9	274	23	chronic	chronic	JJ
cord-006702-ekf6mja9	274	24	kidney	kidney	NN
cord-006702-ekf6mja9	274	25	disease	disease	NN
cord-006702-ekf6mja9	274	26	.	.	.
cord-006702-ekf6mja9	275	1	Q.Z.	Q.Z.	NNP
cord-006702-ekf6mja9	275	2	Chee	Chee	NNP
cord-006702-ekf6mja9	275	3	(	(	-LRB-
cord-006702-ekf6mja9	275	4	1	1	CD
cord-006702-ekf6mja9	275	5	)	)	-RRB-
cord-006702-ekf6mja9	275	6	,	,	,
cord-006702-ekf6mja9	275	7	I.D.	I.D.	NNP
cord-006702-ekf6mja9	275	8	Liu	Liu	NNP
cord-006702-ekf6mja9	275	9	(	(	-LRB-
cord-006702-ekf6mja9	275	10	1	1	CD
cord-006702-ekf6mja9	275	11	)	)	-RRB-
cord-006702-ekf6mja9	275	12	,	,	,
cord-006702-ekf6mja9	275	13	M.	M.	NNP
cord-006702-ekf6mja9	276	1	Than	than	IN
cord-006702-ekf6mja9	277	1	(	(	-LRB-
cord-006702-ekf6mja9	277	2	1	1	LS
cord-006702-ekf6mja9	277	3	)	)	-RRB-
cord-006702-ekf6mja9	277	4	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	277	5	:	:	:
cord-006702-ekf6mja9	277	6	CX3CL1	CX3CL1	NNP
cord-006702-ekf6mja9	277	7	,	,	,
cord-006702-ekf6mja9	277	8	an	an	DT
cord-006702-ekf6mja9	277	9	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	277	10	atherogenic	atherogenic	JJ
cord-006702-ekf6mja9	277	11	chemokine	chemokine	NN
cord-006702-ekf6mja9	277	12	,	,	,
cord-006702-ekf6mja9	277	13	is	be	VBZ
cord-006702-ekf6mja9	277	14	associated	associate	VBN
cord-006702-ekf6mja9	277	15	with	with	IN
cord-006702-ekf6mja9	277	16	severe	severe	JJ
cord-006702-ekf6mja9	277	17	arteriopathy	arteriopathy	NN
cord-006702-ekf6mja9	277	18	in	in	IN
cord-006702-ekf6mja9	277	19	children	child	NNS
cord-006702-ekf6mja9	277	20	with	with	IN
cord-006702-ekf6mja9	277	21	CKD	CKD	NNP
cord-006702-ekf6mja9	277	22	.	.	.
cord-006702-ekf6mja9	278	1	FP	FP	NNP
cord-006702-ekf6mja9	278	2	-	-	HYPH
cord-006702-ekf6mja9	278	3	S11	S11	NNP
cord-006702-ekf6mja9	278	4	-	-	HYPH
cord-006702-ekf6mja9	278	5	2	2	CD
cord-006702-ekf6mja9	278	6	Novel	Novel	NNP
cord-006702-ekf6mja9	278	7	method	method	NN
cord-006702-ekf6mja9	278	8	for	for	IN
cord-006702-ekf6mja9	278	9	the	the	DT
cord-006702-ekf6mja9	278	10	definition	definition	NN
cord-006702-ekf6mja9	278	11	of	of	IN
cord-006702-ekf6mja9	278	12	left	left	JJ
cord-006702-ekf6mja9	278	13	ventricular	ventricular	JJ
cord-006702-ekf6mja9	278	14	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	278	15	improves	improve	VBZ
cord-006702-ekf6mja9	278	16	identification	identification	NN
cord-006702-ekf6mja9	278	17	of	of	IN
cord-006702-ekf6mja9	278	18	risk	risk	NN
cord-006702-ekf6mja9	278	19	phenotype	phenotype	NN
cord-006702-ekf6mja9	278	20	in	in	IN
cord-006702-ekf6mja9	278	21	children	child	NNS
cord-006702-ekf6mja9	278	22	with	with	IN
cord-006702-ekf6mja9	278	23	CKD	CKD	NNP
cord-006702-ekf6mja9	278	24	M.	M.	NNP
cord-006702-ekf6mja9	278	25	Chinali	Chinali	NNP
cord-006702-ekf6mja9	278	26	(	(	-LRB-
cord-006702-ekf6mja9	278	27	1	1	CD
cord-006702-ekf6mja9	278	28	)	)	-RRB-
cord-006702-ekf6mja9	278	29	,	,	.
cord-006702-ekf6mja9	279	1	M.C.	M.C.	NNP
cord-006702-ekf6mja9	279	2	Matteucci	Matteucci	NNP
cord-006702-ekf6mja9	279	3	(	(	-LRB-
cord-006702-ekf6mja9	279	4	1	1	CD
cord-006702-ekf6mja9	279	5	)	)	-RRB-
cord-006702-ekf6mja9	279	6	,	,	,
cord-006702-ekf6mja9	279	7	C.	C.	NNP
cord-006702-ekf6mja9	279	8	Esposito	Esposito	NNP
cord-006702-ekf6mja9	279	9	(	(	-LRB-
cord-006702-ekf6mja9	279	10	1	1	CD
cord-006702-ekf6mja9	279	11	)	)	-RRB-
cord-006702-ekf6mja9	279	12	,	,	,
cord-006702-ekf6mja9	279	13	A.	A.	NNP
cord-006702-ekf6mja9	279	14	Doyon	Doyon	NNP
cord-006702-ekf6mja9	279	15	(	(	-LRB-
cord-006702-ekf6mja9	279	16	2	2	CD
cord-006702-ekf6mja9	279	17	)	)	-RRB-
cord-006702-ekf6mja9	279	18	,	,	,
cord-006702-ekf6mja9	279	19	A.	A.	NNP
cord-006702-ekf6mja9	279	20	Franceschini	Franceschini	NNP
cord-006702-ekf6mja9	279	21	(	(	-LRB-
cord-006702-ekf6mja9	279	22	1	1	CD
cord-006702-ekf6mja9	279	23	)	)	-RRB-
cord-006702-ekf6mja9	279	24	,	,	,
cord-006702-ekf6mja9	279	25	F.	F.	NNP
cord-006702-ekf6mja9	279	26	Drago	Drago	NNP
cord-006702-ekf6mja9	279	27	(	(	-LRB-
cord-006702-ekf6mja9	279	28	1	1	CD
cord-006702-ekf6mja9	279	29	)	)	-RRB-
cord-006702-ekf6mja9	279	30	,	,	,
cord-006702-ekf6mja9	279	31	F.	F.	NNP
cord-006702-ekf6mja9	279	32	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	279	33	(	(	-LRB-
cord-006702-ekf6mja9	279	34	2	2	CD
cord-006702-ekf6mja9	279	35	)	)	-RRB-
cord-006702-ekf6mja9	279	36	,	,	,
cord-006702-ekf6mja9	279	37	F.	F.	NNP
cord-006702-ekf6mja9	279	38	Emma	Emma	NNP
cord-006702-ekf6mja9	279	39	(	(	-LRB-
cord-006702-ekf6mja9	279	40	1	1	CD
cord-006702-ekf6mja9	279	41	)	)	-RRB-
cord-006702-ekf6mja9	279	42	(	(	-LRB-
cord-006702-ekf6mja9	279	43	1	1	LS
cord-006702-ekf6mja9	279	44	)	)	-RRB-
cord-006702-ekf6mja9	279	45	Bambino	Bambino	NNP
cord-006702-ekf6mja9	279	46	Gesù	Gesù	NNP
cord-006702-ekf6mja9	279	47	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	279	48	Research	Research	NNP
cord-006702-ekf6mja9	279	49	Hospital	Hospital	NNP
cord-006702-ekf6mja9	279	50	,	,	,
cord-006702-ekf6mja9	279	51	Rome	Rome	NNP
cord-006702-ekf6mja9	279	52	,	,	,
cord-006702-ekf6mja9	279	53	Italy	Italy	NNP
cord-006702-ekf6mja9	279	54	;	;	:
cord-006702-ekf6mja9	279	55	(	(	-LRB-
cord-006702-ekf6mja9	279	56	2	2	LS
cord-006702-ekf6mja9	279	57	)	)	-RRB-
cord-006702-ekf6mja9	279	58	University	University	NNP
cord-006702-ekf6mja9	279	59	of	of	IN
cord-006702-ekf6mja9	279	60	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	279	61	,	,	,
cord-006702-ekf6mja9	279	62	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	279	63	,	,	,
cord-006702-ekf6mja9	279	64	Germany	Germany	NNP
cord-006702-ekf6mja9	279	65	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	279	66	:	:	:
cord-006702-ekf6mja9	280	1	We	-PRON-	PRP
cord-006702-ekf6mja9	280	2	have	have	VBP
cord-006702-ekf6mja9	280	3	recently	recently	RB
cord-006702-ekf6mja9	280	4	reported	report	VBN
cord-006702-ekf6mja9	280	5	that	that	IN
cord-006702-ekf6mja9	280	6	traditional	traditional	JJ
cord-006702-ekf6mja9	280	7	indexation	indexation	NN
cord-006702-ekf6mja9	280	8	of	of	IN
cord-006702-ekf6mja9	280	9	LV	LV	NNP
cord-006702-ekf6mja9	280	10	mass	mass	NN
cord-006702-ekf6mja9	280	11	to	to	IN
cord-006702-ekf6mja9	280	12	the	the	DT
cord-006702-ekf6mja9	280	13	allometric	allometric	JJ
cord-006702-ekf6mja9	280	14	power	power	NN
cord-006702-ekf6mja9	280	15	of	of	IN
cord-006702-ekf6mja9	280	16	2.7	2.7	CD
cord-006702-ekf6mja9	280	17	,	,	,
cord-006702-ekf6mja9	280	18	as	as	IN
cord-006702-ekf6mja9	280	19	curretly	curretly	RB
cord-006702-ekf6mja9	280	20	reccomended	reccomende	VBN
cord-006702-ekf6mja9	280	21	by	by	IN
cord-006702-ekf6mja9	280	22	current	current	JJ
cord-006702-ekf6mja9	280	23	guidelines	guideline	NNS
cord-006702-ekf6mja9	280	24	,	,	,
cord-006702-ekf6mja9	280	25	may	may	MD
cord-006702-ekf6mja9	280	26	result	result	VB
cord-006702-ekf6mja9	280	27	in	in	IN
cord-006702-ekf6mja9	280	28	a	a	DT
cord-006702-ekf6mja9	280	29	significant	significant	JJ
cord-006702-ekf6mja9	280	30	overestimation	overestimation	NN
cord-006702-ekf6mja9	280	31	of	of	IN
cord-006702-ekf6mja9	280	32	LV	LV	NNP
cord-006702-ekf6mja9	280	33	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	280	34	in	in	IN
cord-006702-ekf6mja9	280	35	younger	young	JJR
cord-006702-ekf6mja9	280	36	children	child	NNS
cord-006702-ekf6mja9	280	37	.	.	.
cord-006702-ekf6mja9	281	1	Accordingly	accordingly	RB
cord-006702-ekf6mja9	281	2	we	-PRON-	PRP
cord-006702-ekf6mja9	281	3	have	have	VBP
cord-006702-ekf6mja9	281	4	suggested	suggest	VBN
cord-006702-ekf6mja9	281	5	a	a	DT
cord-006702-ekf6mja9	281	6	simplified	simplify	VBN
cord-006702-ekf6mja9	281	7	indexation	indexation	NN
cord-006702-ekf6mja9	281	8	approach	approach	NN
cord-006702-ekf6mja9	281	9	to	to	TO
cord-006702-ekf6mja9	281	10	overcome	overcome	VB
cord-006702-ekf6mja9	281	11	this	this	DT
cord-006702-ekf6mja9	281	12	issue	issue	NN
cord-006702-ekf6mja9	281	13	(	(	-LRB-
cord-006702-ekf6mja9	281	14	J	J	NNP
cord-006702-ekf6mja9	281	15	Peds	Peds	NNP
cord-006702-ekf6mja9	281	16	2016	2016	CD
cord-006702-ekf6mja9	281	17	)	)	-RRB-
cord-006702-ekf6mja9	281	18	.	.	.
cord-006702-ekf6mja9	282	1	Objective	objective	NN
cord-006702-ekf6mja9	282	2	of	of	IN
cord-006702-ekf6mja9	282	3	the	the	DT
cord-006702-ekf6mja9	282	4	present	present	JJ
cord-006702-ekf6mja9	282	5	study	study	NN
cord-006702-ekf6mja9	282	6	was	be	VBD
cord-006702-ekf6mja9	282	7	to	to	TO
cord-006702-ekf6mja9	282	8	verify	verify	VB
cord-006702-ekf6mja9	282	9	whether	whether	IN
cord-006702-ekf6mja9	282	10	our	-PRON-	PRP$
cord-006702-ekf6mja9	282	11	proposed	propose	VBN
cord-006702-ekf6mja9	282	12	indexation	indexation	NN
cord-006702-ekf6mja9	282	13	improves	improve	VBZ
cord-006702-ekf6mja9	282	14	risk	risk	NN
cord-006702-ekf6mja9	282	15	stratification	stratification	NN
cord-006702-ekf6mja9	282	16	in	in	IN
cord-006702-ekf6mja9	282	17	CKD	CKD	NNP
cord-006702-ekf6mja9	282	18	children	child	NNS
cord-006702-ekf6mja9	282	19	.	.	.
cord-006702-ekf6mja9	283	1	Methods	method	NNS
cord-006702-ekf6mja9	283	2	:	:	:
cord-006702-ekf6mja9	283	3	Overall	overall	JJ
cord-006702-ekf6mja9	283	4	547	547	CD
cord-006702-ekf6mja9	283	5	children	child	NNS
cord-006702-ekf6mja9	283	6	with	with	IN
cord-006702-ekf6mja9	283	7	available	available	JJ
cord-006702-ekf6mja9	283	8	echocardiographic	echocardiographic	JJ
cord-006702-ekf6mja9	283	9	data	datum	NNS
cord-006702-ekf6mja9	283	10	,	,	,
cord-006702-ekf6mja9	283	11	from	from	IN
cord-006702-ekf6mja9	283	12	two	two	CD
cord-006702-ekf6mja9	283	13	multicenter	multicenter	JJ
cord-006702-ekf6mja9	283	14	european	european	JJ
cord-006702-ekf6mja9	283	15	studies	study	NNS
cord-006702-ekf6mja9	283	16	on	on	IN
cord-006702-ekf6mja9	283	17	CKD	CKD	NNP
cord-006702-ekf6mja9	283	18	were	be	VBD
cord-006702-ekf6mja9	283	19	included	include	VBN
cord-006702-ekf6mja9	283	20	(	(	-LRB-
cord-006702-ekf6mja9	283	21	237	237	CD
cord-006702-ekf6mja9	283	22	from	from	IN
cord-006702-ekf6mja9	283	23	the	the	DT
cord-006702-ekf6mja9	283	24	Escape	Escape	NNP
cord-006702-ekf6mja9	283	25	trial	trial	NN
cord-006702-ekf6mja9	283	26	and	and	CC
cord-006702-ekf6mja9	283	27	310	310	CD
cord-006702-ekf6mja9	283	28	from	from	IN
cord-006702-ekf6mja9	283	29	the	the	DT
cord-006702-ekf6mja9	283	30	4C	4c	CD
cord-006702-ekf6mja9	283	31	study	study	NN
cord-006702-ekf6mja9	283	32	)	)	-RRB-
cord-006702-ekf6mja9	283	33	.	.	.
cord-006702-ekf6mja9	284	1	Presence	presence	NN
cord-006702-ekf6mja9	284	2	of	of	IN
cord-006702-ekf6mja9	284	3	LV	LV	NNP
cord-006702-ekf6mja9	284	4	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	284	5	was	be	VBD
cord-006702-ekf6mja9	284	6	defined	define	VBN
cord-006702-ekf6mja9	284	7	using	use	VBG
cord-006702-ekf6mja9	284	8	partiction	partiction	NN
cord-006702-ekf6mja9	284	9	values	value	NNS
cord-006702-ekf6mja9	284	10	suggested	suggest	VBN
cord-006702-ekf6mja9	284	11	by	by	IN
cord-006702-ekf6mja9	284	12	currect	currect	JJ
cord-006702-ekf6mja9	284	13	guidelines	guideline	NNS
cord-006702-ekf6mja9	284	14	(	(	-LRB-
cord-006702-ekf6mja9	284	15	LVM>38g	LVM>38g	NNP
cord-006702-ekf6mja9	284	16	/	/	SYM
cord-006702-ekf6mja9	284	17	m2.7	m2.7	NNP
cord-006702-ekf6mja9	284	18	)	)	-RRB-
cord-006702-ekf6mja9	284	19	and	and	CC
cord-006702-ekf6mja9	284	20	by	by	IN
cord-006702-ekf6mja9	284	21	our	-PRON-	PRP$
cord-006702-ekf6mja9	284	22	recetluy	recetluy	NN
cord-006702-ekf6mja9	284	23	suggested	suggest	VBD
cord-006702-ekf6mja9	284	24	approach	approach	NN
cord-006702-ekf6mja9	284	25	[	[	-LRB-
cord-006702-ekf6mja9	284	26	LVM>(45g	LVM>(45g	NNP
cord-006702-ekf6mja9	284	27	/	/	SYM
cord-006702-ekf6mja9	284	28	m2.16)+0.09	m2.16)+0.09	NN
cord-006702-ekf6mja9	284	29	]	]	-RRB-
cord-006702-ekf6mja9	284	30	.	.	.
cord-006702-ekf6mja9	285	1	Differences	difference	NNS
cord-006702-ekf6mja9	285	2	in	in	IN
cord-006702-ekf6mja9	285	3	the	the	DT
cord-006702-ekf6mja9	285	4	two	two	CD
cord-006702-ekf6mja9	285	5	methods	method	NNS
cord-006702-ekf6mja9	285	6	in	in	IN
cord-006702-ekf6mja9	285	7	the	the	DT
cord-006702-ekf6mja9	285	8	identification	identification	NN
cord-006702-ekf6mja9	285	9	of	of	IN
cord-006702-ekf6mja9	285	10	children	child	NNS
cord-006702-ekf6mja9	285	11	with	with	IN
cord-006702-ekf6mja9	285	12	impaired	impaired	JJ
cord-006702-ekf6mja9	285	13	systolic	systolic	JJ
cord-006702-ekf6mja9	285	14	function	function	NN
cord-006702-ekf6mja9	285	15	were	be	VBD
cord-006702-ekf6mja9	285	16	reported	report	VBN
cord-006702-ekf6mja9	285	17	.	.	.
cord-006702-ekf6mja9	286	1	Results	result	NNS
cord-006702-ekf6mja9	286	2	:	:	:
cord-006702-ekf6mja9	287	1	Using	use	VBG
cord-006702-ekf6mja9	287	2	the	the	DT
cord-006702-ekf6mja9	287	3	traditional	traditional	JJ
cord-006702-ekf6mja9	287	4	partition	partition	NN
cord-006702-ekf6mja9	287	5	value	value	NN
cord-006702-ekf6mja9	287	6	LV	LV	NNP
cord-006702-ekf6mja9	287	7	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	287	8	(	(	-LRB-
cord-006702-ekf6mja9	287	9	tLVH	tlvh	NN
cord-006702-ekf6mja9	287	10	)	)	-RRB-
cord-006702-ekf6mja9	287	11	could	could	MD
cord-006702-ekf6mja9	287	12	be	be	VB
cord-006702-ekf6mja9	287	13	identified	identify	VBN
cord-006702-ekf6mja9	287	14	in	in	IN
cord-006702-ekf6mja9	287	15	217	217	CD
cord-006702-ekf6mja9	287	16	children	child	NNS
cord-006702-ekf6mja9	287	17	representing	represent	VBG
cord-006702-ekf6mja9	287	18	39.6	39.6	CD
cord-006702-ekf6mja9	287	19	%	%	NN
cord-006702-ekf6mja9	287	20	of	of	IN
cord-006702-ekf6mja9	287	21	the	the	DT
cord-006702-ekf6mja9	287	22	total	total	JJ
cord-006702-ekf6mja9	287	23	population	population	NN
cord-006702-ekf6mja9	287	24	.	.	.
cord-006702-ekf6mja9	288	1	In	in	IN
cord-006702-ekf6mja9	288	2	contrast	contrast	NN
cord-006702-ekf6mja9	288	3	,	,	,
cord-006702-ekf6mja9	288	4	our	-PRON-	PRP$
cord-006702-ekf6mja9	288	5	proposed	propose	VBN
cord-006702-ekf6mja9	288	6	method	method	NN
cord-006702-ekf6mja9	288	7	identified	identify	VBD
cord-006702-ekf6mja9	288	8	LV	LV	NNP
cord-006702-ekf6mja9	288	9	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	288	10	(	(	-LRB-
cord-006702-ekf6mja9	288	11	nLVH	nLVH	NNP
cord-006702-ekf6mja9	288	12	)	)	-RRB-
cord-006702-ekf6mja9	288	13	in	in	IN
cord-006702-ekf6mja9	288	14	183	183	CD
cord-006702-ekf6mja9	288	15	children	child	NNS
cord-006702-ekf6mja9	288	16	,	,	,
cord-006702-ekf6mja9	288	17	reporesenting	reporesente	VBG
cord-006702-ekf6mja9	288	18	33.4	33.4	CD
cord-006702-ekf6mja9	288	19	%	%	NN
cord-006702-ekf6mja9	288	20	of	of	IN
cord-006702-ekf6mja9	288	21	the	the	DT
cord-006702-ekf6mja9	288	22	whole	whole	JJ
cord-006702-ekf6mja9	288	23	population	population	NN
cord-006702-ekf6mja9	288	24	.	.	.
cord-006702-ekf6mja9	289	1	Despite	despite	IN
cord-006702-ekf6mja9	289	2	major	major	JJ
cord-006702-ekf6mja9	289	3	accordance	accordance	NN
cord-006702-ekf6mja9	289	4	among	among	IN
cord-006702-ekf6mja9	289	5	methods	method	NNS
cord-006702-ekf6mja9	289	6	(	(	-LRB-
cord-006702-ekf6mja9	289	7	kappa	kappa	NNP
cord-006702-ekf6mja9	289	8	score	score	NN
cord-006702-ekf6mja9	289	9	0.78	0.78	CD
cord-006702-ekf6mja9	289	10	)	)	-RRB-
cord-006702-ekf6mja9	289	11	,	,	,
cord-006702-ekf6mja9	289	12	tLVH	tLVH	NNP
cord-006702-ekf6mja9	289	13	was	be	VBD
cord-006702-ekf6mja9	289	14	identified	identify	VBN
cord-006702-ekf6mja9	289	15	in	in	IN
cord-006702-ekf6mja9	289	16	46	46	CD
cord-006702-ekf6mja9	289	17	patients	patient	NNS
cord-006702-ekf6mja9	289	18	without	without	IN
cord-006702-ekf6mja9	289	19	nLVH	nLVH	NNP
cord-006702-ekf6mja9	289	20	,	,	,
cord-006702-ekf6mja9	289	21	while	while	IN
cord-006702-ekf6mja9	289	22	nLVH	nLVH	NNP
cord-006702-ekf6mja9	289	23	identified	identify	VBN
cord-006702-ekf6mja9	289	24	12	12	CD
cord-006702-ekf6mja9	289	25	patients	patient	NNS
cord-006702-ekf6mja9	289	26	without	without	IN
cord-006702-ekf6mja9	289	27	tLVH	tlvh	NN
cord-006702-ekf6mja9	289	28	.	.	.
cord-006702-ekf6mja9	290	1	Of	of	IN
cord-006702-ekf6mja9	290	2	note	note	NN
cord-006702-ekf6mja9	290	3	,	,	,
cord-006702-ekf6mja9	290	4	children	child	NNS
cord-006702-ekf6mja9	290	5	with	with	IN
cord-006702-ekf6mja9	290	6	tLVH	tlvh	CD
cord-006702-ekf6mja9	290	7	,	,	,
cord-006702-ekf6mja9	290	8	but	but	CC
cord-006702-ekf6mja9	290	9	not	not	RB
cord-006702-ekf6mja9	290	10	nLVH	nLVH	NNP
cord-006702-ekf6mja9	290	11	were	be	VBD
cord-006702-ekf6mja9	290	12	significantly	significantly	RB
cord-006702-ekf6mja9	290	13	younger	young	JJR
cord-006702-ekf6mja9	290	14	as	as	IN
cord-006702-ekf6mja9	290	15	compred	compre	VBN
cord-006702-ekf6mja9	290	16	to	to	IN
cord-006702-ekf6mja9	290	17	the	the	DT
cord-006702-ekf6mja9	290	18	rest	rest	NN
cord-006702-ekf6mja9	290	19	of	of	IN
cord-006702-ekf6mja9	290	20	the	the	DT
cord-006702-ekf6mja9	290	21	population	population	NN
cord-006702-ekf6mja9	290	22	(	(	-LRB-
cord-006702-ekf6mja9	290	23	8.12+/-3.45years	8.12+/-3.45years	NNP
cord-006702-ekf6mja9	290	24	vs	vs	IN
cord-006702-ekf6mja9	290	25	14.32+/-5.22years	14.32+/-5.22years	CD
cord-006702-ekf6mja9	290	26	)	)	-RRB-
cord-006702-ekf6mja9	290	27	and	and	CC
cord-006702-ekf6mja9	290	28	did	do	VBD
cord-006702-ekf6mja9	290	29	not	not	RB
cord-006702-ekf6mja9	290	30	show	show	VB
cord-006702-ekf6mja9	290	31	any	any	DT
cord-006702-ekf6mja9	290	32	reduction	reduction	NN
cord-006702-ekf6mja9	290	33	in	in	IN
cord-006702-ekf6mja9	290	34	measures	measure	NNS
cord-006702-ekf6mja9	290	35	of	of	IN
cord-006702-ekf6mja9	290	36	chamber	chamber	NN
cord-006702-ekf6mja9	290	37	and	and	CC
cord-006702-ekf6mja9	290	38	or	or	CC
cord-006702-ekf6mja9	290	39	regional	regional	JJ
cord-006702-ekf6mja9	290	40	cardiac	cardiac	NN
cord-006702-ekf6mja9	290	41	funtion	funtion	NN
cord-006702-ekf6mja9	290	42	(	(	-LRB-
cord-006702-ekf6mja9	290	43	all	all	DT
cord-006702-ekf6mja9	290	44	p	p	NN
cord-006702-ekf6mja9	290	45	=	=	SYM
cord-006702-ekf6mja9	290	46	NS	NS	NNP
cord-006702-ekf6mja9	290	47	)	)	-RRB-
cord-006702-ekf6mja9	290	48	.	.	.
cord-006702-ekf6mja9	291	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	291	2	:	:	:
cord-006702-ekf6mja9	292	1	Traditional	traditional	JJ
cord-006702-ekf6mja9	292	2	definition	definition	NN
cord-006702-ekf6mja9	292	3	of	of	IN
cord-006702-ekf6mja9	292	4	LV	LV	NNP
cord-006702-ekf6mja9	292	5	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	292	6	significantly	significantly	RB
cord-006702-ekf6mja9	292	7	overestimates	overestimate	VBZ
cord-006702-ekf6mja9	292	8	the	the	DT
cord-006702-ekf6mja9	292	9	prevalence	prevalence	NN
cord-006702-ekf6mja9	292	10	of	of	IN
cord-006702-ekf6mja9	292	11	LVH	LVH	NNP
cord-006702-ekf6mja9	292	12	in	in	IN
cord-006702-ekf6mja9	292	13	children	child	NNS
cord-006702-ekf6mja9	292	14	with	with	IN
cord-006702-ekf6mja9	292	15	CKD	CKD	NNP
cord-006702-ekf6mja9	292	16	.	.	.
cord-006702-ekf6mja9	293	1	Overestimation	overestimation	NN
cord-006702-ekf6mja9	293	2	is	be	VBZ
cord-006702-ekf6mja9	293	3	more	more	RBR
cord-006702-ekf6mja9	293	4	prominent	prominent	JJ
cord-006702-ekf6mja9	293	5	in	in	IN
cord-006702-ekf6mja9	293	6	the	the	DT
cord-006702-ekf6mja9	293	7	very	very	RB
cord-006702-ekf6mja9	293	8	young	young	JJ
cord-006702-ekf6mja9	293	9	children	child	NNS
cord-006702-ekf6mja9	293	10	,	,	,
cord-006702-ekf6mja9	293	11	in	in	IN
cord-006702-ekf6mja9	293	12	which	which	WDT
cord-006702-ekf6mja9	293	13	no	no	DT
cord-006702-ekf6mja9	293	14	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	293	15	in	in	IN
cord-006702-ekf6mja9	293	16	cardiac	cardiac	JJ
cord-006702-ekf6mja9	293	17	function	function	NN
cord-006702-ekf6mja9	293	18	are	be	VBP
cord-006702-ekf6mja9	293	19	in	in	IN
cord-006702-ekf6mja9	293	20	fact	fact	NN
cord-006702-ekf6mja9	293	21	found	find	VBN
cord-006702-ekf6mja9	293	22	.	.	.
cord-006702-ekf6mja9	294	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	294	2	porposed	porposed	JJ
cord-006702-ekf6mja9	294	3	simplified	simplified	JJ
cord-006702-ekf6mja9	294	4	approach	approach	NN
cord-006702-ekf6mja9	294	5	for	for	IN
cord-006702-ekf6mja9	294	6	the	the	DT
cord-006702-ekf6mja9	294	7	definition	definition	NN
cord-006702-ekf6mja9	294	8	of	of	IN
cord-006702-ekf6mja9	294	9	LV	LV	NNP
cord-006702-ekf6mja9	294	10	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	294	11	reduces	reduce	VBZ
cord-006702-ekf6mja9	294	12	this	this	DT
cord-006702-ekf6mja9	294	13	overestimation	overestimation	NN
cord-006702-ekf6mja9	294	14	and	and	CC
cord-006702-ekf6mja9	294	15	improves	improve	VBZ
cord-006702-ekf6mja9	294	16	correct	correct	JJ
cord-006702-ekf6mja9	294	17	risk	risk	NN
cord-006702-ekf6mja9	294	18	stratification	stratification	NN
cord-006702-ekf6mja9	294	19	in	in	IN
cord-006702-ekf6mja9	294	20	CKD	CKD	NNP
cord-006702-ekf6mja9	294	21	children	child	NNS
cord-006702-ekf6mja9	294	22	.	.	.
cord-006702-ekf6mja9	295	1	FP	FP	NNP
cord-006702-ekf6mja9	295	2	-	-	HYPH
cord-006702-ekf6mja9	295	3	S11	S11	NNP
cord-006702-ekf6mja9	295	4	-	-	HYPH
cord-006702-ekf6mja9	295	5	3	3	CD
cord-006702-ekf6mja9	295	6	Very	very	RB
cord-006702-ekf6mja9	295	7	high	high	JJ
cord-006702-ekf6mja9	295	8	resolution	resolution	NN
cord-006702-ekf6mja9	295	9	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	295	10	reveals	reveal	VBZ
cord-006702-ekf6mja9	295	11	intimal	intimal	JJ
cord-006702-ekf6mja9	295	12	and	and	CC
cord-006702-ekf6mja9	295	13	medial	medial	JJ
cord-006702-ekf6mja9	295	14	vascular	vascular	JJ
cord-006702-ekf6mja9	295	15	remodelling	remodelling	NN
cord-006702-ekf6mja9	295	16	in	in	IN
cord-006702-ekf6mja9	295	17	dialysis	dialysis	NN
cord-006702-ekf6mja9	295	18	and	and	CC
cord-006702-ekf6mja9	295	19	transplant	transplant	NN
cord-006702-ekf6mja9	295	20	patients	patient	NNS
cord-006702-ekf6mja9	295	21	F.	F.	NNP
cord-006702-ekf6mja9	295	22	Dangardt	Dangardt	NNP
cord-006702-ekf6mja9	295	23	(	(	-LRB-
cord-006702-ekf6mja9	295	24	1	1	CD
cord-006702-ekf6mja9	295	25	)	)	-RRB-
cord-006702-ekf6mja9	295	26	,	,	,
cord-006702-ekf6mja9	295	27	D.	D.	NNP
cord-006702-ekf6mja9	295	28	Bhowruth	Bhowruth	NNP
cord-006702-ekf6mja9	295	29	(	(	-LRB-
cord-006702-ekf6mja9	295	30	1	1	CD
cord-006702-ekf6mja9	295	31	)	)	-RRB-
cord-006702-ekf6mja9	295	32	,	,	,
cord-006702-ekf6mja9	295	33	A.	A.	NNP
cord-006702-ekf6mja9	295	34	Rapala	Rapala	NNP
cord-006702-ekf6mja9	295	35	(	(	-LRB-
cord-006702-ekf6mja9	295	36	1	1	CD
cord-006702-ekf6mja9	295	37	)	)	-RRB-
cord-006702-ekf6mja9	295	38	,	,	,
cord-006702-ekf6mja9	295	39	M.	M.	NNP
cord-006702-ekf6mja9	295	40	Charakida	Charakida	NNP
cord-006702-ekf6mja9	295	41	(	(	-LRB-
cord-006702-ekf6mja9	295	42	1	1	CD
cord-006702-ekf6mja9	295	43	)	)	-RRB-
cord-006702-ekf6mja9	295	44	,	,	,
cord-006702-ekf6mja9	295	45	D.	D.	NNP
cord-006702-ekf6mja9	295	46	Thurn	Thurn	NNP
cord-006702-ekf6mja9	295	47	(	(	-LRB-
cord-006702-ekf6mja9	295	48	2	2	CD
cord-006702-ekf6mja9	295	49	)	)	-RRB-
cord-006702-ekf6mja9	295	50	,	,	,
cord-006702-ekf6mja9	295	51	F.	F.	NNP
cord-006702-ekf6mja9	295	52	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	295	53	(	(	-LRB-
cord-006702-ekf6mja9	295	54	2	2	CD
cord-006702-ekf6mja9	295	55	)	)	-RRB-
cord-006702-ekf6mja9	295	56	,	,	,
cord-006702-ekf6mja9	295	57	J.	J.	NNP
cord-006702-ekf6mja9	295	58	Deanfield	Deanfield	NNP
cord-006702-ekf6mja9	295	59	(	(	-LRB-
cord-006702-ekf6mja9	295	60	1	1	CD
cord-006702-ekf6mja9	295	61	)	)	-RRB-
cord-006702-ekf6mja9	295	62	,	,	.
cord-006702-ekf6mja9	296	1	R.	R.	NNP
cord-006702-ekf6mja9	296	2	Shroff	Shroff	NNP
cord-006702-ekf6mja9	296	3	Results	Results	NNP
cord-006702-ekf6mja9	296	4	:	:	:
cord-006702-ekf6mja9	297	1	At	at	IN
cord-006702-ekf6mja9	297	2	baseline	baseline	NN
cord-006702-ekf6mja9	297	3	,	,	,
cord-006702-ekf6mja9	297	4	radial	radial	JJ
cord-006702-ekf6mja9	297	5	artery	artery	NN
cord-006702-ekf6mja9	297	6	IT	it	NN
cord-006702-ekf6mja9	297	7	and	and	CC
cord-006702-ekf6mja9	297	8	pedal	pedal	NN
cord-006702-ekf6mja9	297	9	MT	MT	NNP
cord-006702-ekf6mja9	297	10	were	be	VBD
cord-006702-ekf6mja9	297	11	increased	increase	VBN
cord-006702-ekf6mja9	297	12	in	in	IN
cord-006702-ekf6mja9	297	13	patients	patient	NNS
cord-006702-ekf6mja9	297	14	compared	compare	VBN
cord-006702-ekf6mja9	297	15	to	to	IN
cord-006702-ekf6mja9	297	16	controls	control	NNS
cord-006702-ekf6mja9	297	17	,	,	,
cord-006702-ekf6mja9	297	18	most	most	RBS
cord-006702-ekf6mja9	297	19	markedly	markedly	RB
cord-006702-ekf6mja9	297	20	in	in	IN
cord-006702-ekf6mja9	297	21	children	child	NNS
cord-006702-ekf6mja9	297	22	on	on	IN
cord-006702-ekf6mja9	297	23	dialysis	dialysis	NN
cord-006702-ekf6mja9	297	24	.	.	.
cord-006702-ekf6mja9	298	1	Children	child	NNS
cord-006702-ekf6mja9	298	2	who	who	WP
cord-006702-ekf6mja9	298	3	had	have	VBD
cord-006702-ekf6mja9	298	4	been	be	VBN
cord-006702-ekf6mja9	298	5	on	on	IN
cord-006702-ekf6mja9	298	6	dialysis	dialysis	NN
cord-006702-ekf6mja9	298	7	for	for	IN
cord-006702-ekf6mja9	298	8	more	more	JJR
cord-006702-ekf6mja9	298	9	than	than	IN
cord-006702-ekf6mja9	298	10	one	one	CD
cord-006702-ekf6mja9	298	11	year	year	NN
cord-006702-ekf6mja9	298	12	had	have	VBD
cord-006702-ekf6mja9	298	13	significantly	significantly	RB
cord-006702-ekf6mja9	298	14	greater	great	JJR
cord-006702-ekf6mja9	298	15	carotid	carotid	NN
cord-006702-ekf6mja9	298	16	and	and	CC
cord-006702-ekf6mja9	298	17	dorsal	dorsal	NN
cord-006702-ekf6mja9	298	18	pedal	pedal	NN
cord-006702-ekf6mja9	298	19	MT	MT	NNP
cord-006702-ekf6mja9	298	20	compared	compare	VBN
cord-006702-ekf6mja9	298	21	to	to	IN
cord-006702-ekf6mja9	298	22	those	those	DT
cord-006702-ekf6mja9	298	23	on	on	IN
cord-006702-ekf6mja9	298	24	dialysis	dialysis	NN
cord-006702-ekf6mja9	298	25	for	for	IN
cord-006702-ekf6mja9	298	26	less	less	JJR
cord-006702-ekf6mja9	298	27	than	than	IN
cord-006702-ekf6mja9	298	28	one	one	CD
cord-006702-ekf6mja9	298	29	year	year	NN
cord-006702-ekf6mja9	298	30	(	(	-LRB-
cord-006702-ekf6mja9	298	31	p=0.007	p=0.007	NNP
cord-006702-ekf6mja9	298	32	)	)	-RRB-
cord-006702-ekf6mja9	298	33	.	.	.
cord-006702-ekf6mja9	299	1	In	in	IN
cord-006702-ekf6mja9	299	2	the	the	DT
cord-006702-ekf6mja9	299	3	CKD	CKD	NNP
cord-006702-ekf6mja9	299	4	and	and	CC
cord-006702-ekf6mja9	299	5	dialysis	dialysis	NN
cord-006702-ekf6mja9	299	6	cohort	cohort	NN
cord-006702-ekf6mja9	299	7	(	(	-LRB-
cord-006702-ekf6mja9	299	8	n=39	n=39	NNP
cord-006702-ekf6mja9	299	9	)	)	-RRB-
cord-006702-ekf6mja9	299	10	,	,	,
cord-006702-ekf6mja9	299	11	higher	high	JJR
cord-006702-ekf6mja9	299	12	carotid	carotid	JJ
cord-006702-ekf6mja9	299	13	MT	MT	NNP
cord-006702-ekf6mja9	299	14	at	at	IN
cord-006702-ekf6mja9	299	15	baseline	baseline	NN
cord-006702-ekf6mja9	299	16	was	be	VBD
cord-006702-ekf6mja9	299	17	associated	associate	VBN
cord-006702-ekf6mja9	299	18	with	with	IN
cord-006702-ekf6mja9	299	19	increased	increase	VBN
cord-006702-ekf6mja9	299	20	serum	serum	NN
cord-006702-ekf6mja9	299	21	phosphate	phosphate	NN
cord-006702-ekf6mja9	299	22	(	(	-LRB-
cord-006702-ekf6mja9	299	23	p<0.001	p<0.001	NNS
cord-006702-ekf6mja9	299	24	,	,	,
cord-006702-ekf6mja9	299	25	r=0.42	r=0.42	NNP
cord-006702-ekf6mja9	299	26	)	)	-RRB-
cord-006702-ekf6mja9	299	27	and	and	CC
cord-006702-ekf6mja9	299	28	PTH	PTH	NNP
cord-006702-ekf6mja9	299	29	levels	level	NNS
cord-006702-ekf6mja9	299	30	(	(	-LRB-
cord-006702-ekf6mja9	299	31	p=0.03	p=0.03	NNP
cord-006702-ekf6mja9	299	32	,	,	,
cord-006702-ekf6mja9	299	33	r=0.27	r=0.27	NNP
cord-006702-ekf6mja9	299	34	)	)	-RRB-
cord-006702-ekf6mja9	299	35	.	.	.
cord-006702-ekf6mja9	300	1	No	no	DT
cord-006702-ekf6mja9	300	2	correlation	correlation	NN
cord-006702-ekf6mja9	300	3	was	be	VBD
cord-006702-ekf6mja9	300	4	seen	see	VBN
cord-006702-ekf6mja9	300	5	with	with	IN
cord-006702-ekf6mja9	300	6	25hydroxyvitamin	25hydroxyvitamin	CD
cord-006702-ekf6mja9	300	7	D	d	NN
cord-006702-ekf6mja9	300	8	,	,	,
cord-006702-ekf6mja9	300	9	FGF23	FGF23	NNP
cord-006702-ekf6mja9	300	10	or	or	CC
cord-006702-ekf6mja9	300	11	BMI	BMI	NNP
cord-006702-ekf6mja9	300	12	on	on	IN
cord-006702-ekf6mja9	300	13	any	any	DT
cord-006702-ekf6mja9	300	14	vascular	vascular	JJ
cord-006702-ekf6mja9	300	15	measures	measure	NNS
cord-006702-ekf6mja9	300	16	.	.	.
cord-006702-ekf6mja9	301	1	Higher	high	JJR
cord-006702-ekf6mja9	301	2	carotid	carotid	NN
cord-006702-ekf6mja9	301	3	and	and	CC
cord-006702-ekf6mja9	301	4	radial	radial	JJ
cord-006702-ekf6mja9	301	5	IT	it	PRP
cord-006702-ekf6mja9	301	6	were	be	VBD
cord-006702-ekf6mja9	301	7	associated	associate	VBN
cord-006702-ekf6mja9	301	8	with	with	IN
cord-006702-ekf6mja9	301	9	higher	high	JJR
cord-006702-ekf6mja9	301	10	lipid	lipid	NN
cord-006702-ekf6mja9	301	11	levels	level	NNS
cord-006702-ekf6mja9	301	12	(	(	-LRB-
cord-006702-ekf6mja9	301	13	p=0.03	p=0.03	NNP
cord-006702-ekf6mja9	301	14	,	,	,
cord-006702-ekf6mja9	301	15	r=0.31	r=0.31	NNP
cord-006702-ekf6mja9	301	16	)	)	-RRB-
cord-006702-ekf6mja9	301	17	in	in	IN
cord-006702-ekf6mja9	301	18	all	all	DT
cord-006702-ekf6mja9	301	19	patients	patient	NNS
cord-006702-ekf6mja9	301	20	.	.	.
cord-006702-ekf6mja9	302	1	At	at	IN
cord-006702-ekf6mja9	302	2	1-year	1-year	CD
cord-006702-ekf6mja9	302	3	follow	follow	NN
cord-006702-ekf6mja9	302	4	-	-	HYPH
cord-006702-ekf6mja9	302	5	up	up	NN
cord-006702-ekf6mja9	302	6	transplanted	transplant	VBN
cord-006702-ekf6mja9	302	7	children	child	NNS
cord-006702-ekf6mja9	302	8	had	have	VBD
cord-006702-ekf6mja9	302	9	a	a	DT
cord-006702-ekf6mja9	302	10	17	17	CD
cord-006702-ekf6mja9	302	11	%	%	NN
cord-006702-ekf6mja9	302	12	decrease	decrease	NN
cord-006702-ekf6mja9	302	13	in	in	IN
cord-006702-ekf6mja9	302	14	carotid	carotid	JJ
cord-006702-ekf6mja9	302	15	MT	MT	NNP
cord-006702-ekf6mja9	302	16	(	(	-LRB-
cord-006702-ekf6mja9	302	17	p=0.01	p=0.01	NNP
cord-006702-ekf6mja9	302	18	)	)	-RRB-
cord-006702-ekf6mja9	302	19	but	but	CC
cord-006702-ekf6mja9	302	20	not	not	RB
cord-006702-ekf6mja9	302	21	IT	it	PRP
cord-006702-ekf6mja9	302	22	.	.	.
cord-006702-ekf6mja9	303	1	Increased	increase	VBN
cord-006702-ekf6mja9	303	2	dorsal	dorsal	NN
cord-006702-ekf6mja9	303	3	pedal	pedal	NN
cord-006702-ekf6mja9	303	4	IT	it	PRP
cord-006702-ekf6mja9	303	5	in	in	IN
cord-006702-ekf6mja9	303	6	transplanted	transplanted	JJ
cord-006702-ekf6mja9	303	7	patients	patient	NNS
cord-006702-ekf6mja9	303	8	was	be	VBD
cord-006702-ekf6mja9	303	9	associated	associate	VBN
cord-006702-ekf6mja9	303	10	with	with	IN
cord-006702-ekf6mja9	303	11	a	a	DT
cord-006702-ekf6mja9	303	12	higher	high	JJR
cord-006702-ekf6mja9	303	13	systolic	systolic	JJ
cord-006702-ekf6mja9	303	14	BP	BP	NNP
cord-006702-ekf6mja9	303	15	z	z	NN
cord-006702-ekf6mja9	303	16	-	-	HYPH
cord-006702-ekf6mja9	303	17	score	score	NN
cord-006702-ekf6mja9	303	18	(	(	-LRB-
cord-006702-ekf6mja9	303	19	p	p	NN
cord-006702-ekf6mja9	303	20	=	=	SYM
cord-006702-ekf6mja9	303	21	0.2	0.2	CD
cord-006702-ekf6mja9	303	22	,	,	,
cord-006702-ekf6mja9	303	23	r	r	NN
cord-006702-ekf6mja9	303	24	=	=	SYM
cord-006702-ekf6mja9	303	25	0.22	0.22	CD
cord-006702-ekf6mja9	303	26	)	)	-RRB-
cord-006702-ekf6mja9	303	27	.	.	.
cord-006702-ekf6mja9	304	1	The	the	DT
cord-006702-ekf6mja9	304	2	composite	composite	JJ
cord-006702-ekf6mja9	304	3	measure	measure	NN
cord-006702-ekf6mja9	304	4	of	of	IN
cord-006702-ekf6mja9	304	5	cIMT	cimt	NN
cord-006702-ekf6mja9	304	6	by	by	IN
cord-006702-ekf6mja9	304	7	CUS	CUS	NNP
cord-006702-ekf6mja9	304	8	did	do	VBD
cord-006702-ekf6mja9	304	9	not	not	RB
cord-006702-ekf6mja9	304	10	reveal	reveal	VB
cord-006702-ekf6mja9	304	11	any	any	DT
cord-006702-ekf6mja9	304	12	significant	significant	JJ
cord-006702-ekf6mja9	304	13	changes	change	NNS
cord-006702-ekf6mja9	304	14	in	in	IN
cord-006702-ekf6mja9	304	15	IT	it	PRP
cord-006702-ekf6mja9	304	16	at	at	IN
cord-006702-ekf6mja9	304	17	baseline	baseline	NN
cord-006702-ekf6mja9	304	18	and	and	CC
cord-006702-ekf6mja9	304	19	follow	follow	NN
cord-006702-ekf6mja9	304	20	-	-	HYPH
cord-006702-ekf6mja9	304	21	up	up	NN
cord-006702-ekf6mja9	304	22	.	.	.
cord-006702-ekf6mja9	305	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	305	2	:	:	:
cord-006702-ekf6mja9	306	1	CKD	CKD	NNP
cord-006702-ekf6mja9	306	2	patients	patient	NNS
cord-006702-ekf6mja9	306	3	have	have	VBP
cord-006702-ekf6mja9	306	4	modifiable	modifiable	JJ
cord-006702-ekf6mja9	306	5	risk	risk	NN
cord-006702-ekf6mja9	306	6	factors	factor	NNS
cord-006702-ekf6mja9	306	7	for	for	IN
cord-006702-ekf6mja9	306	8	intimal	intimal	JJ
cord-006702-ekf6mja9	306	9	and	and	CC
cord-006702-ekf6mja9	306	10	medial	medial	JJ
cord-006702-ekf6mja9	306	11	vascular	vascular	JJ
cord-006702-ekf6mja9	306	12	disease	disease	NN
cord-006702-ekf6mja9	306	13	which	which	WDT
cord-006702-ekf6mja9	306	14	were	be	VBD
cord-006702-ekf6mja9	306	15	not	not	RB
cord-006702-ekf6mja9	306	16	detected	detect	VBN
cord-006702-ekf6mja9	306	17	by	by	IN
cord-006702-ekf6mja9	306	18	CUS	CUS	NNP
cord-006702-ekf6mja9	306	19	.	.	.
cord-006702-ekf6mja9	307	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	307	2	findings	finding	NNS
cord-006702-ekf6mja9	307	3	suggest	suggest	VBP
cord-006702-ekf6mja9	307	4	vascular	vascular	JJ
cord-006702-ekf6mja9	307	5	remodeling	remodeling	NN
cord-006702-ekf6mja9	307	6	in	in	IN
cord-006702-ekf6mja9	307	7	response	response	NN
cord-006702-ekf6mja9	307	8	to	to	IN
cord-006702-ekf6mja9	307	9	a	a	DT
cord-006702-ekf6mja9	307	10	changing	change	VBG
cord-006702-ekf6mja9	307	11	cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	307	12	risk	risk	NN
cord-006702-ekf6mja9	307	13	factor	factor	NN
cord-006702-ekf6mja9	307	14	profile	profile	NN
cord-006702-ekf6mja9	307	15	after	after	IN
cord-006702-ekf6mja9	307	16	transplantation	transplantation	NN
cord-006702-ekf6mja9	307	17	and	and	CC
cord-006702-ekf6mja9	307	18	provides	provide	VBZ
cord-006702-ekf6mja9	307	19	important	important	JJ
cord-006702-ekf6mja9	307	20	information	information	NN
cord-006702-ekf6mja9	307	21	for	for	IN
cord-006702-ekf6mja9	307	22	effective	effective	JJ
cord-006702-ekf6mja9	307	23	CV	CV	NNP
cord-006702-ekf6mja9	307	24	risk	risk	NN
cord-006702-ekf6mja9	307	25	stratification	stratification	NN
cord-006702-ekf6mja9	307	26	and	and	CC
cord-006702-ekf6mja9	307	27	treatment	treatment	NN
cord-006702-ekf6mja9	307	28	.	.	.
cord-006702-ekf6mja9	308	1	FP	FP	NNP
cord-006702-ekf6mja9	308	2	-	-	HYPH
cord-006702-ekf6mja9	308	3	S12	S12	NNP
cord-006702-ekf6mja9	308	4	-	-	HYPH
cord-006702-ekf6mja9	308	5	1	1	CD
cord-006702-ekf6mja9	309	1	X	X	NNS
cord-006702-ekf6mja9	309	2	linked	link	VBN
cord-006702-ekf6mja9	309	3	hypophosphatemia	hypophosphatemia	NN
cord-006702-ekf6mja9	309	4	(	(	-LRB-
cord-006702-ekf6mja9	309	5	XLH	XLH	NNP
cord-006702-ekf6mja9	309	6	)	)	-RRB-
cord-006702-ekf6mja9	309	7	and	and	CC
cord-006702-ekf6mja9	309	8	growth	growth	NN
cord-006702-ekf6mja9	309	9	:	:	:
cord-006702-ekf6mja9	309	10	GH	gh	NN
cord-006702-ekf6mja9	309	11	and	and	CC
cord-006702-ekf6mja9	309	12	MAPKi	MAPKi	NNS
cord-006702-ekf6mja9	309	13	treatments	treatment	NNS
cord-006702-ekf6mja9	309	14	R.	R.	NNP
cord-006702-ekf6mja9	309	15	Fuente	Fuente	NNP
cord-006702-ekf6mja9	309	16	(	(	-LRB-
cord-006702-ekf6mja9	309	17	1	1	CD
cord-006702-ekf6mja9	309	18	)	)	-RRB-
cord-006702-ekf6mja9	309	19	,	,	,
cord-006702-ekf6mja9	309	20	H.	H.	NNP
cord-006702-ekf6mja9	309	21	Gil	Gil	NNP
cord-006702-ekf6mja9	309	22	-	-	HYPH
cord-006702-ekf6mja9	309	23	peña	peña	NNP
cord-006702-ekf6mja9	309	24	(	(	-LRB-
cord-006702-ekf6mja9	309	25	2	2	CD
cord-006702-ekf6mja9	309	26	)	)	-RRB-
cord-006702-ekf6mja9	309	27	,	,	,
cord-006702-ekf6mja9	309	28	L.	L.	NNP
cord-006702-ekf6mja9	309	29	Alonso	Alonso	NNP
cord-006702-ekf6mja9	309	30	(	(	-LRB-
cord-006702-ekf6mja9	309	31	2	2	CD
cord-006702-ekf6mja9	309	32	)	)	-RRB-
cord-006702-ekf6mja9	309	33	,	,	,
cord-006702-ekf6mja9	309	34	O.	O.	NNP
cord-006702-ekf6mja9	309	35	Hernández	Hernández	NNP
cord-006702-ekf6mja9	309	36	(	(	-LRB-
cord-006702-ekf6mja9	309	37	1	1	CD
cord-006702-ekf6mja9	309	38	)	)	-RRB-
cord-006702-ekf6mja9	309	39	,	,	,
cord-006702-ekf6mja9	309	40	Á.	Á.	NNP
cord-006702-ekf6mja9	309	41	Férnandez	Férnandez	NNP
cord-006702-ekf6mja9	309	42	(	(	-LRB-
cord-006702-ekf6mja9	309	43	1	1	CD
cord-006702-ekf6mja9	309	44	)	)	-RRB-
cord-006702-ekf6mja9	310	1	Objectives	objective	NNS
cord-006702-ekf6mja9	310	2	:	:	:
cord-006702-ekf6mja9	310	3	To	to	TO
cord-006702-ekf6mja9	310	4	analyze	analyze	VB
cord-006702-ekf6mja9	310	5	the	the	DT
cord-006702-ekf6mja9	310	6	potential	potential	JJ
cord-006702-ekf6mja9	310	7	effect	effect	NN
cord-006702-ekf6mja9	310	8	on	on	IN
cord-006702-ekf6mja9	310	9	growth	growth	NN
cord-006702-ekf6mja9	310	10	and	and	CC
cord-006702-ekf6mja9	310	11	bone	bone	NN
cord-006702-ekf6mja9	310	12	of	of	IN
cord-006702-ekf6mja9	310	13	P	P	NNP
cord-006702-ekf6mja9	310	14	-	-	HYPH
cord-006702-ekf6mja9	310	15	ERK1/2	ERK1/2	NNP
cord-006702-ekf6mja9	310	16	inhibition	inhibition	NN
cord-006702-ekf6mja9	310	17	(	(	-LRB-
cord-006702-ekf6mja9	310	18	blocking	blocking	NN
cord-006702-ekf6mja9	310	19	of	of	IN
cord-006702-ekf6mja9	310	20	FGF23-MAPKinase	FGF23-MAPKinase	NNP
cord-006702-ekf6mja9	310	21	pathway	pathway	NN
cord-006702-ekf6mja9	310	22	)	)	-RRB-
cord-006702-ekf6mja9	310	23	in	in	IN
cord-006702-ekf6mja9	310	24	comparison	comparison	NN
cord-006702-ekf6mja9	310	25	with	with	IN
cord-006702-ekf6mja9	310	26	GH	GH	NNP
cord-006702-ekf6mja9	310	27	treatment	treatment	NN
cord-006702-ekf6mja9	310	28	using	use	VBG
cord-006702-ekf6mja9	310	29	young	young	JJ
cord-006702-ekf6mja9	310	30	Hyp	Hyp	NNP
cord-006702-ekf6mja9	310	31	-	-	HYPH
cord-006702-ekf6mja9	310	32	mice	mouse	NNS
cord-006702-ekf6mja9	310	33	,	,	,
cord-006702-ekf6mja9	310	34	a	a	DT
cord-006702-ekf6mja9	310	35	model	model	NN
cord-006702-ekf6mja9	310	36	of	of	IN
cord-006702-ekf6mja9	310	37	XLH	XLH	NNP
cord-006702-ekf6mja9	310	38	.	.	.
cord-006702-ekf6mja9	311	1	Methods	method	NNS
cord-006702-ekf6mja9	311	2	:	:	:
cord-006702-ekf6mja9	311	3	4	4	CD
cord-006702-ekf6mja9	311	4	groups	group	NNS
cord-006702-ekf6mja9	311	5	(	(	-LRB-
cord-006702-ekf6mja9	311	6	n=6	n=6	NNP
cord-006702-ekf6mja9	311	7	)	)	-RRB-
cord-006702-ekf6mja9	311	8	of	of	IN
cord-006702-ekf6mja9	311	9	mice	mouse	NNS
cord-006702-ekf6mja9	311	10	:	:	:
cord-006702-ekf6mja9	311	11	Wild	wild	JJ
cord-006702-ekf6mja9	311	12	-	-	HYPH
cord-006702-ekf6mja9	311	13	type	type	NN
cord-006702-ekf6mja9	311	14	(	(	-LRB-
cord-006702-ekf6mja9	311	15	Wt	wt	NN
cord-006702-ekf6mja9	311	16	)	)	-RRB-
cord-006702-ekf6mja9	311	17	,	,	,
cord-006702-ekf6mja9	311	18	control	control	NN
cord-006702-ekf6mja9	311	19	Hyp	Hyp	NNP
cord-006702-ekf6mja9	311	20	(	(	-LRB-
cord-006702-ekf6mja9	311	21	Hyp	Hyp	NNP
cord-006702-ekf6mja9	311	22	)	)	-RRB-
cord-006702-ekf6mja9	311	23	,	,	,
cord-006702-ekf6mja9	311	24	Hyp	Hyp	NNP
cord-006702-ekf6mja9	311	25	treated	treat	VBN
cord-006702-ekf6mja9	311	26	with	with	IN
cord-006702-ekf6mja9	311	27	GH	GH	NNP
cord-006702-ekf6mja9	311	28	(	(	-LRB-
cord-006702-ekf6mja9	311	29	Hyp	Hyp	NNP
cord-006702-ekf6mja9	311	30	-	-	HYPH
cord-006702-ekf6mja9	311	31	GH	GH	NNP
cord-006702-ekf6mja9	311	32	,	,	,
cord-006702-ekf6mja9	311	33	3.33	3.33	CD
cord-006702-ekf6mja9	311	34	mg	mg	NNP
cord-006702-ekf6mja9	311	35	/	/	SYM
cord-006702-ekf6mja9	311	36	kg	kg	NNP
cord-006702-ekf6mja9	311	37	/	/	SYM
cord-006702-ekf6mja9	311	38	day	day	NN
cord-006702-ekf6mja9	311	39	)	)	-RRB-
cord-006702-ekf6mja9	311	40	and	and	CC
cord-006702-ekf6mja9	311	41	with	with	IN
cord-006702-ekf6mja9	311	42	P	P	NNP
cord-006702-ekf6mja9	311	43	-	-	HYPH
cord-006702-ekf6mja9	311	44	ERK1/2	ERK1/2	NNP
cord-006702-ekf6mja9	311	45	inhibitor	inhibitor	NN
cord-006702-ekf6mja9	311	46	(	(	-LRB-
cord-006702-ekf6mja9	311	47	Hyp	Hyp	NNP
cord-006702-ekf6mja9	311	48	-	-	HYPH
cord-006702-ekf6mja9	311	49	MAPKi	MAPKi	NNPS
cord-006702-ekf6mja9	311	50	,	,	,
cord-006702-ekf6mja9	311	51	7.5	7.5	CD
cord-006702-ekf6mja9	311	52	mg	mg	NNP
cord-006702-ekf6mja9	311	53	/	/	SYM
cord-006702-ekf6mja9	311	54	kg	kg	NNP
cord-006702-ekf6mja9	311	55	/	/	SYM
cord-006702-ekf6mja9	311	56	day	day	NN
cord-006702-ekf6mja9	311	57	)	)	-RRB-
cord-006702-ekf6mja9	311	58	.	.	.
cord-006702-ekf6mja9	312	1	Studies	study	NNS
cord-006702-ekf6mja9	312	2	after	after	IN
cord-006702-ekf6mja9	312	3	1	1	CD
cord-006702-ekf6mja9	312	4	week	week	NN
cord-006702-ekf6mja9	312	5	:	:	:
cord-006702-ekf6mja9	312	6	Serum	serum	NN
cord-006702-ekf6mja9	312	7	phosphate	phosphate	NN
cord-006702-ekf6mja9	312	8	,	,	,
cord-006702-ekf6mja9	312	9	kidney	kidney	NN
cord-006702-ekf6mja9	312	10	P	p	NN
cord-006702-ekf6mja9	312	11	-	-	HYPH
cord-006702-ekf6mja9	312	12	ERK1/2	ERK1/2	NNP
cord-006702-ekf6mja9	312	13	expression	expression	NN
cord-006702-ekf6mja9	312	14	and	and	CC
cord-006702-ekf6mja9	312	15	NaPi	napi	NN
cord-006702-ekf6mja9	312	16	-	-	HYPH
cord-006702-ekf6mja9	312	17	transporter	transporter	NN
cord-006702-ekf6mja9	312	18	function	function	NN
cord-006702-ekf6mja9	312	19	,	,	,
cord-006702-ekf6mja9	312	20	tibia	tibia	NNP
cord-006702-ekf6mja9	312	21	's	's	POS
cord-006702-ekf6mja9	312	22	growth	growth	NN
cord-006702-ekf6mja9	312	23	plate	plate	NN
cord-006702-ekf6mja9	312	24	histomorphometry	histomorphometry	NN
cord-006702-ekf6mja9	312	25	,	,	,
cord-006702-ekf6mja9	312	26	IGF-1	IGF-1	NNP
cord-006702-ekf6mja9	312	27	expression	expression	NN
cord-006702-ekf6mja9	312	28	,	,	,
cord-006702-ekf6mja9	312	29	proliferation	proliferation	NN
cord-006702-ekf6mja9	312	30	and	and	CC
cord-006702-ekf6mja9	312	31	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	312	32	,	,	,
cord-006702-ekf6mja9	312	33	bone	bone	NN
cord-006702-ekf6mja9	312	34	mineralization	mineralization	NN
cord-006702-ekf6mja9	312	35	and	and	CC
cord-006702-ekf6mja9	312	36	structure	structure	NN
cord-006702-ekf6mja9	312	37	(	(	-LRB-
cord-006702-ekf6mja9	312	38	uCT	uCT	NNP
cord-006702-ekf6mja9	312	39	and	and	CC
cord-006702-ekf6mja9	312	40	Von	Von	NNP
cord-006702-ekf6mja9	312	41	-	-	HYPH
cord-006702-ekf6mja9	312	42	Kossa	Kossa	NNP
cord-006702-ekf6mja9	312	43	)	)	-RRB-
cord-006702-ekf6mja9	312	44	and	and	CC
cord-006702-ekf6mja9	312	45	osteoclastic	osteoclastic	JJ
cord-006702-ekf6mja9	312	46	activity	activity	NN
cord-006702-ekf6mja9	312	47	(	(	-LRB-
cord-006702-ekf6mja9	312	48	TRAP	trap	NN
cord-006702-ekf6mja9	312	49	)	)	-RRB-
cord-006702-ekf6mja9	312	50	.	.	.
cord-006702-ekf6mja9	313	1	Results	result	NNS
cord-006702-ekf6mja9	313	2	:	:	:
cord-006702-ekf6mja9	314	1	Both	both	DT
cord-006702-ekf6mja9	314	2	treatments	treatment	NNS
cord-006702-ekf6mja9	314	3	improved	improve	VBD
cord-006702-ekf6mja9	314	4	hypophosphatemia	hypophosphatemia	NNP
cord-006702-ekf6mja9	314	5	(	(	-LRB-
cord-006702-ekf6mja9	314	6	Wt=7.65±0.37	wt=7.65±0.37	TO
cord-006702-ekf6mja9	314	7	,	,	,
cord-006702-ekf6mja9	314	8	Hyp=3.16±0.22	Hyp=3.16±0.22	NNP
cord-006702-ekf6mja9	314	9	,	,	,
cord-006702-ekf6mja9	314	10	Hyp	Hyp	NNP
cord-006702-ekf6mja9	314	11	-	-	HYPH
cord-006702-ekf6mja9	314	12	GH=5.26±0.06	GH=5.26±0.06	NNP
cord-006702-ekf6mja9	314	13	,	,	,
cord-006702-ekf6mja9	314	14	Hyp	Hyp	NNP
cord-006702-ekf6mja9	314	15	-	-	HYPH
cord-006702-ekf6mja9	314	16	MAPKi=5.08±0.03	MAPKi=5.08±0.03	NNP
cord-006702-ekf6mja9	314	17	mg	mg	NNP
cord-006702-ekf6mja9	314	18	/	/	SYM
cord-006702-ekf6mja9	314	19	dl	dl	NNP
cord-006702-ekf6mja9	314	20	;	;	:
cord-006702-ekf6mja9	314	21	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	314	22	)	)	-RRB-
cord-006702-ekf6mja9	315	1	but	but	CC
cord-006702-ekf6mja9	315	2	not	not	RB
cord-006702-ekf6mja9	315	3	as	as	IN
cord-006702-ekf6mja9	315	4	a	a	DT
cord-006702-ekf6mja9	315	5	result	result	NN
cord-006702-ekf6mja9	315	6	of	of	IN
cord-006702-ekf6mja9	315	7	higher	high	JJR
cord-006702-ekf6mja9	315	8	renal	renal	JJ
cord-006702-ekf6mja9	315	9	NaPi	NaPi	NNP
cord-006702-ekf6mja9	315	10	activity	activity	NN
cord-006702-ekf6mja9	315	11	.	.	.
cord-006702-ekf6mja9	316	1	Nose	nose	NN
cord-006702-ekf6mja9	316	2	-	-	HYPH
cord-006702-ekf6mja9	316	3	tail	tail	NN
cord-006702-ekf6mja9	316	4	and	and	CC
cord-006702-ekf6mja9	316	5	tibia	tibia	NN
cord-006702-ekf6mja9	316	6	lengths	length	NNS
cord-006702-ekf6mja9	316	7	were	be	VBD
cord-006702-ekf6mja9	316	8	significally	significally	RB
cord-006702-ekf6mja9	316	9	increased	increase	VBN
cord-006702-ekf6mja9	316	10	by	by	IN
cord-006702-ekf6mja9	316	11	these	these	DT
cord-006702-ekf6mja9	316	12	treatments	treatment	NNS
cord-006702-ekf6mja9	316	13	.	.	.
cord-006702-ekf6mja9	317	1	In	in	IN
cord-006702-ekf6mja9	317	2	growth	growth	NN
cord-006702-ekf6mja9	317	3	plate	plate	NN
cord-006702-ekf6mja9	317	4	(	(	-LRB-
cord-006702-ekf6mja9	317	5	Figure	figure	NN
cord-006702-ekf6mja9	317	6	)	)	-RRB-
cord-006702-ekf6mja9	317	7	,	,	,
cord-006702-ekf6mja9	317	8	GH	GH	NNP
cord-006702-ekf6mja9	317	9	as	as	RB
cord-006702-ekf6mja9	317	10	well	well	RB
cord-006702-ekf6mja9	317	11	as	as	IN
cord-006702-ekf6mja9	317	12	MAPKi	MAPKi	NNS
cord-006702-ekf6mja9	317	13	increased	increase	VBD
cord-006702-ekf6mja9	317	14	the	the	DT
cord-006702-ekf6mja9	317	15	terminal	terminal	NN
cord-006702-ekf6mja9	317	16	chondrocyte	chondrocyte	NNP
cord-006702-ekf6mja9	317	17	'	'	''
cord-006702-ekf6mja9	317	18	height	height	NN
cord-006702-ekf6mja9	317	19	,	,	,
cord-006702-ekf6mja9	317	20	local	local	JJ
cord-006702-ekf6mja9	317	21	IGF1	IGF1	NNP
cord-006702-ekf6mja9	317	22	expression	expression	NN
cord-006702-ekf6mja9	317	23	and	and	CC
cord-006702-ekf6mja9	317	24	chondrocyte	chondrocyte	NN
cord-006702-ekf6mja9	317	25	proliferation	proliferation	NN
cord-006702-ekf6mja9	317	26	rate	rate	NN
cord-006702-ekf6mja9	317	27	(	(	-LRB-
cord-006702-ekf6mja9	317	28	Table	table	NN
cord-006702-ekf6mja9	317	29	)	)	-RRB-
cord-006702-ekf6mja9	317	30	.	.	.
cord-006702-ekf6mja9	318	1	Caspase	Caspase	NNP
cord-006702-ekf6mja9	318	2	signaling	signaling	NN
cord-006702-ekf6mja9	318	3	was	be	VBD
cord-006702-ekf6mja9	318	4	negative	negative	JJ
cord-006702-ekf6mja9	318	5	for	for	IN
cord-006702-ekf6mja9	318	6	all	all	DT
cord-006702-ekf6mja9	318	7	Hyp	Hyp	NNP
cord-006702-ekf6mja9	318	8	groups	group	NNS
cord-006702-ekf6mja9	318	9	,	,	,
cord-006702-ekf6mja9	318	10	indicating	indicate	VBG
cord-006702-ekf6mja9	318	11	marked	mark	VBN
cord-006702-ekf6mja9	318	12	alteration	alteration	NN
cord-006702-ekf6mja9	318	13	of	of	IN
cord-006702-ekf6mja9	318	14	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	318	15	.	.	.
cord-006702-ekf6mja9	319	1	Growth	growth	NN
cord-006702-ekf6mja9	319	2	cartilage	cartilage	NN
cord-006702-ekf6mja9	319	3	disorganization	disorganization	NN
cord-006702-ekf6mja9	319	4	was	be	VBD
cord-006702-ekf6mja9	319	5	only	only	RB
cord-006702-ekf6mja9	319	6	improved	improve	VBN
cord-006702-ekf6mja9	319	7	by	by	IN
cord-006702-ekf6mja9	319	8	MAPK	MAPK	NNP
cord-006702-ekf6mja9	319	9	inhibition	inhibition	NN
cord-006702-ekf6mja9	319	10	which	which	WDT
cord-006702-ekf6mja9	319	11	also	also	RB
cord-006702-ekf6mja9	319	12	increased	increase	VBD
cord-006702-ekf6mja9	319	13	bone	bone	NN
cord-006702-ekf6mja9	319	14	mineral	mineral	NN
cord-006702-ekf6mja9	319	15	density	density	NN
cord-006702-ekf6mja9	319	16	(	(	-LRB-
cord-006702-ekf6mja9	319	17	Wt:0.26±0.01;Hyp:0.20	Wt:0.26±0.01;Hyp:0.20	NNP
cord-006702-ekf6mja9	319	18	±0.01;Hyp-	±0.01;Hyp-	NNP
cord-006702-ekf6mja9	320	1	GH:0.23±0.02;Hyp	GH:0.23±0.02;Hyp	NNS
cord-006702-ekf6mja9	320	2	-	-	HYPH
cord-006702-ekf6mja9	320	3	MAPK:0.26±0.018	mapk:0.26±0.018	NN
cord-006702-ekf6mja9	320	4	cm3	cm3	NNP
cord-006702-ekf6mja9	320	5	/	/	SYM
cord-006702-ekf6mja9	320	6	g	g	NN
cord-006702-ekf6mja9	320	7	;	;	:
cord-006702-ekf6mja9	320	8	p<0.05	p<0.05	NNP
cord-006702-ekf6mja9	320	9	)	)	-RRB-
cord-006702-ekf6mja9	320	10	and	and	CC
cord-006702-ekf6mja9	320	11	trabecular	trabecular	JJ
cord-006702-ekf6mja9	320	12	number	number	NN
cord-006702-ekf6mja9	320	13	(	(	-LRB-
cord-006702-ekf6mja9	320	14	Wt:5.9±0.3;Hyp:5.4±0.1;Hyp	Wt:5.9±0.3;Hyp:5.4±0.1;Hyp	NNP
cord-006702-ekf6mja9	320	15	-	-	HYPH
cord-006702-ekf6mja9	320	16	GH:6.1±0.1;Hyp	GH:6.1±0.1;Hyp	NNP
cord-006702-ekf6mja9	320	17	-	-	HYPH
cord-006702-ekf6mja9	320	18	MAPK:7.3	MAPK:7.3	NNS
cord-006702-ekf6mja9	320	19	±0.5	±0.5	XX
cord-006702-ekf6mja9	320	20	;	;	:
cord-006702-ekf6mja9	320	21	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	320	22	)	)	-RRB-
cord-006702-ekf6mja9	320	23	.	.	.
cord-006702-ekf6mja9	321	1	In	in	IN
cord-006702-ekf6mja9	321	2	contrast	contrast	NN
cord-006702-ekf6mja9	321	3	,	,	,
cord-006702-ekf6mja9	321	4	GH	GH	NNP
cord-006702-ekf6mja9	321	5	enhanced	enhance	VBD
cord-006702-ekf6mja9	321	6	cortical	cortical	JJ
cord-006702-ekf6mja9	321	7	thickness	thickness	NN
cord-006702-ekf6mja9	321	8	to	to	IN
cord-006702-ekf6mja9	321	9	a	a	DT
cord-006702-ekf6mja9	321	10	greater	great	JJR
cord-006702-ekf6mja9	321	11	extent	extent	NN
cord-006702-ekf6mja9	321	12	(	(	-LRB-
cord-006702-ekf6mja9	321	13	Wt=0.14±0.004	Wt=0.14±0.004	NNP
cord-006702-ekf6mja9	321	14	,	,	,
cord-006702-ekf6mja9	321	15	Hyp=0.07±0.03	Hyp=0.07±0.03	NNP
cord-006702-ekf6mja9	321	16	,	,	,
cord-006702-ekf6mja9	322	1	Hyp	Hyp	NNP
cord-006702-ekf6mja9	322	2	-	-	HYPH
cord-006702-ekf6mja9	322	3	GH=0.09±0.09	GH=0.09±0.09	NNP
cord-006702-ekf6mja9	322	4	Hyp	Hyp	NNP
cord-006702-ekf6mja9	322	5	-	-	HYPH
cord-006702-ekf6mja9	322	6	MAPKi=5.58	mapki=5.58	JJ
cord-006702-ekf6mja9	322	7	±0.27	±0.27	JJ
cord-006702-ekf6mja9	322	8	mm	mm	NN
cord-006702-ekf6mja9	322	9	;	;	:
cord-006702-ekf6mja9	322	10	p<0.02	p<0.02	XX
cord-006702-ekf6mja9	322	11	)	)	-RRB-
cord-006702-ekf6mja9	322	12	.	.	.
cord-006702-ekf6mja9	323	1	TRAP	TRAP	NNP
cord-006702-ekf6mja9	323	2	and	and	CC
cord-006702-ekf6mja9	323	3	Von	Von	NNP
cord-006702-ekf6mja9	323	4	-	-	HYPH
cord-006702-ekf6mja9	323	5	Kossa	Kossa	NNP
cord-006702-ekf6mja9	324	1	staining	stain	VBG
cord-006702-ekf6mja9	324	2	fitted	fit	VBN
cord-006702-ekf6mja9	324	3	with	with	IN
cord-006702-ekf6mja9	324	4	micro	micro	JJ
cord-006702-ekf6mja9	324	5	-	-	JJ
cord-006702-ekf6mja9	324	6	Ct	ct	JJ
cord-006702-ekf6mja9	324	7	analysis	analysis	NN
cord-006702-ekf6mja9	324	8	,	,	,
cord-006702-ekf6mja9	324	9	and	and	CC
cord-006702-ekf6mja9	324	10	disclosed	disclose	VBD
cord-006702-ekf6mja9	324	11	lower	low	JJR
cord-006702-ekf6mja9	324	12	amount	amount	NN
cord-006702-ekf6mja9	324	13	of	of	IN
cord-006702-ekf6mja9	324	14	osteoid	osteoid	NN
cord-006702-ekf6mja9	324	15	in	in	IN
cord-006702-ekf6mja9	324	16	treated	treat	VBN
cord-006702-ekf6mja9	324	17	mice	mouse	NNS
cord-006702-ekf6mja9	324	18	(	(	-LRB-
cord-006702-ekf6mja9	324	19	Table	table	NN
cord-006702-ekf6mja9	324	20	)	)	-RRB-
cord-006702-ekf6mja9	324	21	.	.	.
cord-006702-ekf6mja9	325	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	325	2	:	:	:
cord-006702-ekf6mja9	326	1	GH	GH	NNP
cord-006702-ekf6mja9	326	2	administration	administration	NN
cord-006702-ekf6mja9	326	3	and	and	CC
cord-006702-ekf6mja9	326	4	blocking	blocking	NN
cord-006702-ekf6mja9	326	5	of	of	IN
cord-006702-ekf6mja9	326	6	MAPK	MAPK	NNP
cord-006702-ekf6mja9	326	7	pathway	pathway	NN
cord-006702-ekf6mja9	326	8	improve	improve	VBP
cord-006702-ekf6mja9	326	9	hypophosphatemia	hypophosphatemia	NN
cord-006702-ekf6mja9	326	10	,	,	,
cord-006702-ekf6mja9	326	11	bone	bone	NN
cord-006702-ekf6mja9	326	12	mineralization	mineralization	NN
cord-006702-ekf6mja9	326	13	and	and	CC
cord-006702-ekf6mja9	326	14	body	body	NN
cord-006702-ekf6mja9	326	15	length	length	NN
cord-006702-ekf6mja9	326	16	in	in	IN
cord-006702-ekf6mja9	326	17	Hyp	Hyp	NNP
cord-006702-ekf6mja9	326	18	mice	mouse	NNS
cord-006702-ekf6mja9	326	19	,	,	,
cord-006702-ekf6mja9	326	20	but	but	CC
cord-006702-ekf6mja9	326	21	only	only	RB
cord-006702-ekf6mja9	326	22	MAPKi	MAPKi	NNS
cord-006702-ekf6mja9	326	23	is	be	VBZ
cord-006702-ekf6mja9	326	24	able	able	JJ
cord-006702-ekf6mja9	326	25	to	to	TO
cord-006702-ekf6mja9	326	26	normalize	normalize	VB
cord-006702-ekf6mja9	326	27	growth	growth	NN
cord-006702-ekf6mja9	326	28	plate	plate	NN
cord-006702-ekf6mja9	326	29	structure	structure	NN
cord-006702-ekf6mja9	326	30	and	and	CC
cord-006702-ekf6mja9	326	31	orientation	orientation	NN
cord-006702-ekf6mja9	326	32	.	.	.
cord-006702-ekf6mja9	327	1	GH	GH	NNP
cord-006702-ekf6mja9	327	2	administration	administration	NN
cord-006702-ekf6mja9	327	3	did	do	VBD
cord-006702-ekf6mja9	327	4	not	not	RB
cord-006702-ekf6mja9	327	5	correct	correct	VB
cord-006702-ekf6mja9	327	6	these	these	DT
cord-006702-ekf6mja9	327	7	alterations	alteration	NNS
cord-006702-ekf6mja9	327	8	,	,	,
cord-006702-ekf6mja9	327	9	which	which	WDT
cord-006702-ekf6mja9	327	10	may	may	MD
cord-006702-ekf6mja9	327	11	imply	imply	VB
cord-006702-ekf6mja9	327	12	an	an	DT
cord-006702-ekf6mja9	327	13	increased	increase	VBN
cord-006702-ekf6mja9	327	14	risk	risk	NN
cord-006702-ekf6mja9	327	15	of	of	IN
cord-006702-ekf6mja9	327	16	bone	bone	NN
cord-006702-ekf6mja9	327	17	deformities	deformity	NNS
cord-006702-ekf6mja9	327	18	.	.	.
cord-006702-ekf6mja9	328	1	FP	FP	NNP
cord-006702-ekf6mja9	328	2	-	-	HYPH
cord-006702-ekf6mja9	328	3	S12	S12	NNP
cord-006702-ekf6mja9	328	4	-	-	HYPH
cord-006702-ekf6mja9	328	5	2	2	CD
cord-006702-ekf6mja9	328	6	Progression	progression	NN
cord-006702-ekf6mja9	328	7	of	of	IN
cord-006702-ekf6mja9	328	8	CKD	CKD	NNP
cord-006702-ekf6mja9	328	9	and	and	CC
cord-006702-ekf6mja9	328	10	its	-PRON-	PRP$
cord-006702-ekf6mja9	328	11	determinants	determinant	NNS
cord-006702-ekf6mja9	328	12	in	in	IN
cord-006702-ekf6mja9	328	13	children	child	NNS
cord-006702-ekf6mja9	328	14	with	with	IN
cord-006702-ekf6mja9	328	15	OCRL	ocrl	JJ
cord-006702-ekf6mja9	328	16	mutations	mutation	NNS
cord-006702-ekf6mja9	329	1	-retrospective	-retrospective	DT
cord-006702-ekf6mja9	330	1	analysis	analysis	NN
cord-006702-ekf6mja9	330	2	of	of	IN
cord-006702-ekf6mja9	330	3	a	a	DT
cord-006702-ekf6mja9	330	4	large	large	JJ
cord-006702-ekf6mja9	330	5	international	international	JJ
cord-006702-ekf6mja9	330	6	cohort	cohort	NN
cord-006702-ekf6mja9	330	7	D.	D.	NNP
cord-006702-ekf6mja9	330	8	Böckenhauer	Böckenhauer	NNP
cord-006702-ekf6mja9	330	9	(	(	-LRB-
cord-006702-ekf6mja9	330	10	1	1	CD
cord-006702-ekf6mja9	330	11	)	)	-RRB-
cord-006702-ekf6mja9	331	1	,	,	,
cord-006702-ekf6mja9	331	2	M.	M.	NNP
cord-006702-ekf6mja9	331	3	Zaniew	Zaniew	NNP
cord-006702-ekf6mja9	331	4	(	(	-LRB-
cord-006702-ekf6mja9	331	5	2	2	CD
cord-006702-ekf6mja9	331	6	)	)	-RRB-
cord-006702-ekf6mja9	331	7	,	,	,
cord-006702-ekf6mja9	331	8	A.	A.	NNP
cord-006702-ekf6mja9	331	9	Bökenkamp	Bökenkamp	NNP
cord-006702-ekf6mja9	331	10	(	(	-LRB-
cord-006702-ekf6mja9	331	11	3	3	CD
cord-006702-ekf6mja9	331	12	)	)	-RRB-
cord-006702-ekf6mja9	331	13	,	,	,
cord-006702-ekf6mja9	331	14	M.	M.	NNP
cord-006702-ekf6mja9	331	15	Ludwig	Ludwig	NNP
cord-006702-ekf6mja9	331	16	(	(	-LRB-
cord-006702-ekf6mja9	331	17	4	4	CD
cord-006702-ekf6mja9	331	18	)	)	-RRB-
cord-006702-ekf6mja9	331	19	,	,	,
cord-006702-ekf6mja9	331	20	M.	M.	NNP
cord-006702-ekf6mja9	331	21	Konrad	Konrad	NNP
cord-006702-ekf6mja9	331	22	(	(	-LRB-
cord-006702-ekf6mja9	331	23	5	5	CD
cord-006702-ekf6mja9	331	24	)	)	-RRB-
cord-006702-ekf6mja9	331	25	,	,	,
cord-006702-ekf6mja9	331	26	F.	F.	NNP
cord-006702-ekf6mja9	331	27	Anglani	Anglani	NNP
cord-006702-ekf6mja9	331	28	(	(	-LRB-
cord-006702-ekf6mja9	331	29	6	6	CD
cord-006702-ekf6mja9	331	30	)	)	-RRB-
cord-006702-ekf6mja9	331	31	,	,	,
cord-006702-ekf6mja9	331	32	M.	M.	NNP
cord-006702-ekf6mja9	331	33	Addis	Addis	NNP
cord-006702-ekf6mja9	331	34	(	(	-LRB-
cord-006702-ekf6mja9	331	35	7	7	CD
cord-006702-ekf6mja9	331	36	)	)	-RRB-
cord-006702-ekf6mja9	331	37	,	,	.
cord-006702-ekf6mja9	332	1	H.	H.	NNP
cord-006702-ekf6mja9	332	2	Il	Il	NNP
cord-006702-ekf6mja9	332	3	Cheong	Cheong	NNP
cord-006702-ekf6mja9	332	4	(	(	-LRB-
cord-006702-ekf6mja9	332	5	8	8	CD
cord-006702-ekf6mja9	332	6	Objectives	objective	NNS
cord-006702-ekf6mja9	332	7	:	:	:
cord-006702-ekf6mja9	332	8	Lowe	Lowe	NNP
cord-006702-ekf6mja9	332	9	syndrome	syndrome	NN
cord-006702-ekf6mja9	332	10	(	(	-LRB-
cord-006702-ekf6mja9	332	11	LS	LS	NNP
cord-006702-ekf6mja9	332	12	)	)	-RRB-
cord-006702-ekf6mja9	332	13	and	and	CC
cord-006702-ekf6mja9	332	14	Dent2	Dent2	NNP
cord-006702-ekf6mja9	332	15	disease	disease	NN
cord-006702-ekf6mja9	332	16	(	(	-LRB-
cord-006702-ekf6mja9	332	17	DD2	DD2	NNP
cord-006702-ekf6mja9	332	18	)	)	-RRB-
cord-006702-ekf6mja9	332	19	are	be	VBP
cord-006702-ekf6mja9	332	20	both	both	DT
cord-006702-ekf6mja9	332	21	ultrarare	ultrarare	JJ
cord-006702-ekf6mja9	332	22	X	x	NN
cord-006702-ekf6mja9	332	23	-	-	HYPH
cord-006702-ekf6mja9	332	24	linked	link	VBN
cord-006702-ekf6mja9	332	25	disorders	disorder	NNS
cord-006702-ekf6mja9	332	26	associated	associate	VBN
cord-006702-ekf6mja9	332	27	with	with	IN
cord-006702-ekf6mja9	332	28	mutations	mutation	NNS
cord-006702-ekf6mja9	332	29	in	in	IN
cord-006702-ekf6mja9	332	30	the	the	DT
cord-006702-ekf6mja9	332	31	OCRL	ocrl	JJ
cord-006702-ekf6mja9	332	32	gene	gene	NN
cord-006702-ekf6mja9	332	33	and	and	CC
cord-006702-ekf6mja9	332	34	characterized	characterize	VBN
cord-006702-ekf6mja9	332	35	by	by	IN
cord-006702-ekf6mja9	332	36	progressive	progressive	JJ
cord-006702-ekf6mja9	332	37	chronic	chronic	JJ
cord-006702-ekf6mja9	332	38	kidney	kidney	NN
cord-006702-ekf6mja9	332	39	disease	disease	NN
cord-006702-ekf6mja9	332	40	(	(	-LRB-
cord-006702-ekf6mja9	332	41	CKD	CKD	NNP
cord-006702-ekf6mja9	332	42	)	)	-RRB-
cord-006702-ekf6mja9	332	43	.	.	.
cord-006702-ekf6mja9	333	1	Here	here	RB
cord-006702-ekf6mja9	333	2	,	,	,
cord-006702-ekf6mja9	333	3	we	-PRON-	PRP
cord-006702-ekf6mja9	333	4	aimed	aim	VBD
cord-006702-ekf6mja9	333	5	to	to	TO
cord-006702-ekf6mja9	333	6	investigate	investigate	VB
cord-006702-ekf6mja9	333	7	determinants	determinant	NNS
cord-006702-ekf6mja9	333	8	of	of	IN
cord-006702-ekf6mja9	333	9	CKD	CKD	NNP
cord-006702-ekf6mja9	333	10	and	and	CC
cord-006702-ekf6mja9	333	11	its	-PRON-	PRP$
cord-006702-ekf6mja9	333	12	progression	progression	NN
cord-006702-ekf6mja9	333	13	in	in	IN
cord-006702-ekf6mja9	333	14	children	child	NNS
cord-006702-ekf6mja9	333	15	with	with	IN
cord-006702-ekf6mja9	333	16	these	these	DT
cord-006702-ekf6mja9	333	17	tubulopathies	tubulopathie	NNS
cord-006702-ekf6mja9	333	18	.	.	.
cord-006702-ekf6mja9	334	1	Methods	method	NNS
cord-006702-ekf6mja9	334	2	:	:	:
cord-006702-ekf6mja9	334	3	Retrospective	Retrospective	NNP
cord-006702-ekf6mja9	334	4	,	,	,
cord-006702-ekf6mja9	334	5	analyses	analysis	NNS
cord-006702-ekf6mja9	334	6	of	of	IN
cord-006702-ekf6mja9	334	7	clinical	clinical	JJ
cord-006702-ekf6mja9	334	8	and	and	CC
cord-006702-ekf6mja9	334	9	genetic	genetic	JJ
cord-006702-ekf6mja9	334	10	data	datum	NNS
cord-006702-ekf6mja9	334	11	in	in	IN
cord-006702-ekf6mja9	334	12	a	a	DT
cord-006702-ekf6mja9	334	13	cohort	cohort	NN
cord-006702-ekf6mja9	334	14	of	of	IN
cord-006702-ekf6mja9	334	15	106	106	CD
cord-006702-ekf6mja9	334	16	boys	boy	NNS
cord-006702-ekf6mja9	334	17	(	(	-LRB-
cord-006702-ekf6mja9	334	18	LS	ls	NN
cord-006702-ekf6mja9	334	19	:	:	:
cord-006702-ekf6mja9	334	20	88	88	CD
cord-006702-ekf6mja9	334	21	and	and	CC
cord-006702-ekf6mja9	334	22	DD2	DD2	NNP
cord-006702-ekf6mja9	334	23	:	:	:
cord-006702-ekf6mja9	334	24	18	18	CD
cord-006702-ekf6mja9	334	25	)	)	-RRB-
cord-006702-ekf6mja9	334	26	.	.	.
cord-006702-ekf6mja9	335	1	For	for	IN
cord-006702-ekf6mja9	335	2	genotype	genotype	NN
cord-006702-ekf6mja9	335	3	-	-	HYPH
cord-006702-ekf6mja9	335	4	phenotype	phenotype	NN
cord-006702-ekf6mja9	335	5	analysis	analysis	NN
cord-006702-ekf6mja9	335	6	,	,	,
cord-006702-ekf6mja9	335	7	we	-PRON-	PRP
cord-006702-ekf6mja9	335	8	grouped	group	VBD
cord-006702-ekf6mja9	335	9	mutations	mutation	NNS
cord-006702-ekf6mja9	335	10	according	accord	VBG
cord-006702-ekf6mja9	335	11	to	to	IN
cord-006702-ekf6mja9	335	12	their	-PRON-	PRP$
cord-006702-ekf6mja9	335	13	type	type	NN
cord-006702-ekf6mja9	335	14	and	and	CC
cord-006702-ekf6mja9	335	15	localization	localization	NN
cord-006702-ekf6mja9	335	16	.	.	.
cord-006702-ekf6mja9	336	1	Results	result	NNS
cord-006702-ekf6mja9	336	2	:	:	:
cord-006702-ekf6mja9	337	1	Median	median	JJ
cord-006702-ekf6mja9	337	2	eGFR	egfr	NN
cord-006702-ekf6mja9	337	3	was	be	VBD
cord-006702-ekf6mja9	337	4	lower	low	JJR
cord-006702-ekf6mja9	337	5	in	in	IN
cord-006702-ekf6mja9	337	6	the	the	DT
cord-006702-ekf6mja9	337	7	LS	LS	NNP
cord-006702-ekf6mja9	337	8	group	group	NN
cord-006702-ekf6mja9	337	9	compared	compare	VBN
cord-006702-ekf6mja9	337	10	to	to	IN
cord-006702-ekf6mja9	337	11	DD2	DD2	NNP
cord-006702-ekf6mja9	337	12	(	(	-LRB-
cord-006702-ekf6mja9	337	13	58.8	58.8	CD
cord-006702-ekf6mja9	337	14	vs.	vs.	FW
cord-006702-ekf6mja9	337	15	87.4	87.4	CD
cord-006702-ekf6mja9	337	16	ml	ml	XX
cord-006702-ekf6mja9	337	17	/	/	SYM
cord-006702-ekf6mja9	337	18	min/1.73	min/1.73	JJ
cord-006702-ekf6mja9	337	19	m	m	CD
cord-006702-ekf6mja9	337	20	2	2	CD
cord-006702-ekf6mja9	337	21	,	,	,
cord-006702-ekf6mja9	337	22	p<0.05	p<0.05	CD
cord-006702-ekf6mja9	337	23	)	)	-RRB-
cord-006702-ekf6mja9	337	24	.	.	.
cord-006702-ekf6mja9	338	1	CKD	CKD	NNP
cord-006702-ekf6mja9	338	2	stage	stage	NN
cord-006702-ekf6mja9	339	1	II	II	NNP
cord-006702-ekf6mja9	339	2	-	-	:
cord-006702-ekf6mja9	339	3	Vwas	Vwas	NNP
cord-006702-ekf6mja9	339	4	found	find	VBD
cord-006702-ekf6mja9	339	5	in	in	IN
cord-006702-ekf6mja9	339	6	81	81	CD
cord-006702-ekf6mja9	339	7	%	%	NN
cord-006702-ekf6mja9	339	8	of	of	IN
cord-006702-ekf6mja9	339	9	all	all	DT
cord-006702-ekf6mja9	339	10	patients	patient	NNS
cord-006702-ekf6mja9	339	11	,	,	,
cord-006702-ekf6mja9	339	12	of	of	IN
cord-006702-ekf6mja9	339	13	these	these	DT
cord-006702-ekf6mja9	339	14	58	58	CD
cord-006702-ekf6mja9	339	15	%	%	NN
cord-006702-ekf6mja9	339	16	and	and	CC
cord-006702-ekf6mja9	339	17	27	27	CD
cord-006702-ekf6mja9	339	18	%	%	NN
cord-006702-ekf6mja9	339	19	had	have	VBD
cord-006702-ekf6mja9	339	20	moderate	moderate	JJ
cord-006702-ekf6mja9	339	21	to	to	TO
cord-006702-ekf6mja9	339	22	severe	severe	JJ
cord-006702-ekf6mja9	339	23	CKD	CKD	NNP
cord-006702-ekf6mja9	339	24	,	,	,
cord-006702-ekf6mja9	339	25	in	in	IN
cord-006702-ekf6mja9	339	26	LS	LS	NNP
cord-006702-ekf6mja9	339	27	and	and	CC
cord-006702-ekf6mja9	339	28	DD2	DD2	NNP
cord-006702-ekf6mja9	339	29	respectively	respectively	RB
cord-006702-ekf6mja9	339	30	.	.	.
cord-006702-ekf6mja9	340	1	ESRD	ESRD	NNP
cord-006702-ekf6mja9	340	2	was	be	VBD
cord-006702-ekf6mja9	340	3	found	find	VBN
cord-006702-ekf6mja9	340	4	in	in	IN
cord-006702-ekf6mja9	340	5	three	three	CD
cord-006702-ekf6mja9	340	6	individuals	individual	NNS
cord-006702-ekf6mja9	340	7	with	with	IN
cord-006702-ekf6mja9	340	8	LS	LS	NNP
cord-006702-ekf6mja9	340	9	.	.	.
cord-006702-ekf6mja9	341	1	Trajectories	trajectory	NNS
cord-006702-ekf6mja9	341	2	of	of	IN
cord-006702-ekf6mja9	341	3	eGFR	egfr	NN
cord-006702-ekf6mja9	341	4	showed	show	VBD
cord-006702-ekf6mja9	341	5	a	a	DT
cord-006702-ekf6mja9	341	6	slow	slow	JJ
cord-006702-ekf6mja9	341	7	progression	progression	NN
cord-006702-ekf6mja9	341	8	of	of	IN
cord-006702-ekf6mja9	341	9	CKD	CKD	NNP
cord-006702-ekf6mja9	341	10	with	with	IN
cord-006702-ekf6mja9	341	11	a	a	DT
cord-006702-ekf6mja9	341	12	decline	decline	NN
cord-006702-ekf6mja9	341	13	in	in	IN
cord-006702-ekf6mja9	341	14	eGFR	egfr	NN
cord-006702-ekf6mja9	341	15	at	at	IN
cord-006702-ekf6mja9	341	16	the	the	DT
cord-006702-ekf6mja9	341	17	age	age	NN
cord-006702-ekf6mja9	341	18	of	of	IN
cord-006702-ekf6mja9	341	19	10	10	CD
cord-006702-ekf6mja9	341	20	years	year	NNS
cord-006702-ekf6mja9	341	21	in	in	IN
cord-006702-ekf6mja9	341	22	the	the	DT
cord-006702-ekf6mja9	341	23	LS	LS	NNP
cord-006702-ekf6mja9	341	24	group	group	NN
cord-006702-ekf6mja9	341	25	,	,	,
cord-006702-ekf6mja9	341	26	whereas	whereas	IN
cord-006702-ekf6mja9	341	27	in	in	IN
cord-006702-ekf6mja9	341	28	subjects	subject	NNS
cord-006702-ekf6mja9	341	29	with	with	IN
cord-006702-ekf6mja9	341	30	DD2	DD2	NNP
cord-006702-ekf6mja9	341	31	,	,	,
cord-006702-ekf6mja9	341	32	eGFR	eGFR	NNP
cord-006702-ekf6mja9	341	33	remained	remain	VBD
cord-006702-ekf6mja9	341	34	stable	stable	JJ
cord-006702-ekf6mja9	341	35	throughout	throughout	IN
cord-006702-ekf6mja9	341	36	childhood	childhood	NN
cord-006702-ekf6mja9	341	37	.	.	.
cord-006702-ekf6mja9	342	1	Moreover	moreover	RB
cord-006702-ekf6mja9	342	2	,	,	,
cord-006702-ekf6mja9	342	3	patients	patient	NNS
cord-006702-ekf6mja9	342	4	with	with	IN
cord-006702-ekf6mja9	342	5	mutations	mutation	NNS
cord-006702-ekf6mja9	342	6	clustered	cluster	VBN
cord-006702-ekf6mja9	342	7	in	in	IN
cord-006702-ekf6mja9	342	8	exons	exon	NNS
cord-006702-ekf6mja9	342	9	21	21	CD
cord-006702-ekf6mja9	342	10	-	-	SYM
cord-006702-ekf6mja9	342	11	24	24	CD
cord-006702-ekf6mja9	342	12	had	have	VBD
cord-006702-ekf6mja9	342	13	lower	low	JJR
cord-006702-ekf6mja9	342	14	eGFR	egfr	NN
cord-006702-ekf6mja9	342	15	and	and	CC
cord-006702-ekf6mja9	342	16	worse	bad	JJR
cord-006702-ekf6mja9	342	17	CKD	CKD	NNP
cord-006702-ekf6mja9	342	18	progression	progression	NN
cord-006702-ekf6mja9	342	19	.	.	.
cord-006702-ekf6mja9	343	1	There	there	EX
cord-006702-ekf6mja9	343	2	was	be	VBD
cord-006702-ekf6mja9	343	3	no	no	DT
cord-006702-ekf6mja9	343	4	significant	significant	JJ
cord-006702-ekf6mja9	343	5	association	association	NN
cord-006702-ekf6mja9	343	6	between	between	IN
cord-006702-ekf6mja9	343	7	type	type	NN
cord-006702-ekf6mja9	343	8	of	of	IN
cord-006702-ekf6mja9	343	9	mutation	mutation	NN
cord-006702-ekf6mja9	343	10	,	,	,
cord-006702-ekf6mja9	343	11	presence	presence	NN
cord-006702-ekf6mja9	343	12	of	of	IN
cord-006702-ekf6mja9	343	13	nephrocalcinosis	nephrocalcinosis	NNP
cord-006702-ekf6mja9	343	14	,	,	,
cord-006702-ekf6mja9	343	15	hypercalciuria	hypercalciuria	NNP
cord-006702-ekf6mja9	343	16	,	,	,
cord-006702-ekf6mja9	343	17	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	343	18	and	and	CC
cord-006702-ekf6mja9	343	19	number	number	NN
cord-006702-ekf6mja9	343	20	of	of	IN
cord-006702-ekf6mja9	343	21	adverse	adverse	JJ
cord-006702-ekf6mja9	343	22	clinical	clinical	JJ
cord-006702-ekf6mja9	343	23	events	event	NNS
cord-006702-ekf6mja9	343	24	and	and	CC
cord-006702-ekf6mja9	343	25	CKD	CKD	NNP
cord-006702-ekf6mja9	343	26	.	.	.
cord-006702-ekf6mja9	344	1	Overall	overall	RB
cord-006702-ekf6mja9	344	2	,	,	,
cord-006702-ekf6mja9	344	3	54	54	CD
cord-006702-ekf6mja9	344	4	%	%	NN
cord-006702-ekf6mja9	344	5	were	be	VBD
cord-006702-ekf6mja9	344	6	treated	treat	VBN
cord-006702-ekf6mja9	344	7	with	with	IN
cord-006702-ekf6mja9	344	8	alkali	alkali	NN
cord-006702-ekf6mja9	344	9	therapy	therapy	NN
cord-006702-ekf6mja9	344	10	for	for	IN
cord-006702-ekf6mja9	344	11	acidosis	acidosis	NN
cord-006702-ekf6mja9	344	12	.	.	.
cord-006702-ekf6mja9	345	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	345	2	:	:	:
cord-006702-ekf6mja9	346	1	This	this	DT
cord-006702-ekf6mja9	346	2	study	study	NN
cord-006702-ekf6mja9	346	3	shows	show	VBZ
cord-006702-ekf6mja9	346	4	worse	bad	JJR
cord-006702-ekf6mja9	346	5	CKD	CKD	NNP
cord-006702-ekf6mja9	346	6	progression	progression	NN
cord-006702-ekf6mja9	346	7	for	for	IN
cord-006702-ekf6mja9	346	8	children	child	NNS
cord-006702-ekf6mja9	346	9	with	with	IN
cord-006702-ekf6mja9	346	10	LS	ls	NN
cord-006702-ekf6mja9	346	11	compared	compare	VBN
cord-006702-ekf6mja9	346	12	to	to	IN
cord-006702-ekf6mja9	346	13	DD2	DD2	NNP
cord-006702-ekf6mja9	346	14	.	.	.
cord-006702-ekf6mja9	347	1	Localization	localization	NN
cord-006702-ekf6mja9	347	2	,	,	,
cord-006702-ekf6mja9	347	3	but	but	CC
cord-006702-ekf6mja9	347	4	not	not	RB
cord-006702-ekf6mja9	347	5	type	type	NN
cord-006702-ekf6mja9	347	6	of	of	IN
cord-006702-ekf6mja9	347	7	mutation	mutation	NN
cord-006702-ekf6mja9	347	8	is	be	VBZ
cord-006702-ekf6mja9	347	9	associated	associate	VBN
cord-006702-ekf6mja9	347	10	with	with	IN
cord-006702-ekf6mja9	347	11	CKD	CKD	NNP
cord-006702-ekf6mja9	347	12	progression	progression	NN
cord-006702-ekf6mja9	347	13	.	.	.
cord-006702-ekf6mja9	348	1	FP	FP	NNP
cord-006702-ekf6mja9	348	2	-	-	HYPH
cord-006702-ekf6mja9	348	3	S12	S12	NNP
cord-006702-ekf6mja9	348	4	-	-	HYPH
cord-006702-ekf6mja9	348	5	3	3	CD
cord-006702-ekf6mja9	348	6	Significant	significant	JJ
cord-006702-ekf6mja9	348	7	Increase	increase	NN
cord-006702-ekf6mja9	348	8	in	in	IN
cord-006702-ekf6mja9	348	9	Urinary	urinary	JJ
cord-006702-ekf6mja9	348	10	Excretion	Excretion	NNP
cord-006702-ekf6mja9	348	11	of	of	IN
cord-006702-ekf6mja9	348	12	Apolipoproteins	Apolipoproteins	NNP
cord-006702-ekf6mja9	348	13	and	and	CC
cord-006702-ekf6mja9	348	14	Fatty	fatty	JJ
cord-006702-ekf6mja9	348	15	Acid	acid	NN
cord-006702-ekf6mja9	348	16	-	-	HYPH
cord-006702-ekf6mja9	348	17	Binding	bind	VBG
cord-006702-ekf6mja9	348	18	Protein	Protein	NNP
cord-006702-ekf6mja9	348	19	in	in	IN
cord-006702-ekf6mja9	348	20	Children	Children	NNP
cord-006702-ekf6mja9	348	21	with	with	IN
cord-006702-ekf6mja9	348	22	Nephrolithiasis	Nephrolithiasis	NNP
cord-006702-ekf6mja9	348	23	and	and	CC
cord-006702-ekf6mja9	348	24	Hypercalciuria	Hypercalciuria	NNP
cord-006702-ekf6mja9	348	25	L.	L.	NNP
cord-006702-ekf6mja9	348	26	Kovacevic	Kovacevic	NNP
cord-006702-ekf6mja9	348	27	(	(	-LRB-
cord-006702-ekf6mja9	348	28	1	1	CD
cord-006702-ekf6mja9	348	29	)	)	-RRB-
cord-006702-ekf6mja9	348	30	,	,	,
cord-006702-ekf6mja9	348	31	T.	T.	NNP
cord-006702-ekf6mja9	348	32	Govil	Govil	NNP
cord-006702-ekf6mja9	348	33	-	-	HYPH
cord-006702-ekf6mja9	348	34	dalela	dalela	NNP
cord-006702-ekf6mja9	348	35	(	(	-LRB-
cord-006702-ekf6mja9	348	36	1	1	CD
cord-006702-ekf6mja9	348	37	)	)	-RRB-
cord-006702-ekf6mja9	348	38	,	,	,
cord-006702-ekf6mja9	348	39	N.	N.	NNP
cord-006702-ekf6mja9	348	40	Kovacevic	Kovacevic	NNP
cord-006702-ekf6mja9	348	41	(	(	-LRB-
cord-006702-ekf6mja9	348	42	1	1	CD
cord-006702-ekf6mja9	348	43	)	)	-RRB-
cord-006702-ekf6mja9	348	44	,	,	,
cord-006702-ekf6mja9	348	45	H.	H.	NNP
cord-006702-ekf6mja9	348	46	Lu	Lu	NNP
cord-006702-ekf6mja9	348	47	(	(	-LRB-
cord-006702-ekf6mja9	348	48	1	1	CD
cord-006702-ekf6mja9	348	49	)	)	-RRB-
cord-006702-ekf6mja9	348	50	,	,	,
cord-006702-ekf6mja9	348	51	J.A.	J.A.	NNP
cord-006702-ekf6mja9	348	52	Caruso	Caruso	NNP
cord-006702-ekf6mja9	348	53	(	(	-LRB-
cord-006702-ekf6mja9	348	54	2	2	CD
cord-006702-ekf6mja9	348	55	)	)	-RRB-
cord-006702-ekf6mja9	348	56	,	,	,
cord-006702-ekf6mja9	348	57	R.	R.	NNP
cord-006702-ekf6mja9	348	58	Thomas	Thomas	NNP
cord-006702-ekf6mja9	348	59	(	(	-LRB-
cord-006702-ekf6mja9	348	60	1	1	CD
cord-006702-ekf6mja9	348	61	)	)	-RRB-
cord-006702-ekf6mja9	348	62	,	,	,
cord-006702-ekf6mja9	348	63	Y.	Y.	NNP
cord-006702-ekf6mja9	348	64	Lakshmanan	Lakshmanan	NNP
cord-006702-ekf6mja9	348	65	(	(	-LRB-
cord-006702-ekf6mja9	348	66	1	1	CD
cord-006702-ekf6mja9	348	67	)	)	-RRB-
cord-006702-ekf6mja9	348	68	(	(	-LRB-
cord-006702-ekf6mja9	348	69	1	1	LS
cord-006702-ekf6mja9	348	70	)	)	-RRB-
cord-006702-ekf6mja9	348	71	Children	Children	NNPS
cord-006702-ekf6mja9	348	72	's	's	POS
cord-006702-ekf6mja9	348	73	Hospital	Hospital	NNP
cord-006702-ekf6mja9	348	74	of	of	IN
cord-006702-ekf6mja9	348	75	Michigan	Michigan	NNP
cord-006702-ekf6mja9	348	76	,	,	,
cord-006702-ekf6mja9	348	77	Detroit	Detroit	NNP
cord-006702-ekf6mja9	348	78	,	,	,
cord-006702-ekf6mja9	348	79	United	United	NNP
cord-006702-ekf6mja9	348	80	States	States	NNP
cord-006702-ekf6mja9	348	81	;	;	:
cord-006702-ekf6mja9	348	82	(	(	-LRB-
cord-006702-ekf6mja9	348	83	2	2	LS
cord-006702-ekf6mja9	348	84	)	)	-RRB-
cord-006702-ekf6mja9	348	85	Institute	Institute	NNP
cord-006702-ekf6mja9	348	86	of	of	IN
cord-006702-ekf6mja9	348	87	Environmental	Environmental	NNP
cord-006702-ekf6mja9	348	88	Health	Health	NNP
cord-006702-ekf6mja9	348	89	Sciences	Sciences	NNPS
cord-006702-ekf6mja9	348	90	,	,	,
cord-006702-ekf6mja9	348	91	Wayne	Wayne	NNP
cord-006702-ekf6mja9	348	92	State	State	NNP
cord-006702-ekf6mja9	348	93	University	University	NNP
cord-006702-ekf6mja9	348	94	,	,	,
cord-006702-ekf6mja9	348	95	Detroit	Detroit	NNP
cord-006702-ekf6mja9	348	96	,	,	,
cord-006702-ekf6mja9	348	97	United	United	NNP
cord-006702-ekf6mja9	348	98	States	States	NNP
cord-006702-ekf6mja9	348	99	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	348	100	:	:	:
cord-006702-ekf6mja9	349	1	Using	use	VBG
cord-006702-ekf6mja9	349	2	a	a	DT
cord-006702-ekf6mja9	349	3	proteomic	proteomic	JJ
cord-006702-ekf6mja9	349	4	model	model	NN
cord-006702-ekf6mja9	349	5	and	and	CC
cord-006702-ekf6mja9	349	6	pooled	pool	VBN
cord-006702-ekf6mja9	349	7	samples	sample	NNS
cord-006702-ekf6mja9	349	8	,	,	,
cord-006702-ekf6mja9	349	9	we	-PRON-	PRP
cord-006702-ekf6mja9	349	10	have	have	VBP
cord-006702-ekf6mja9	349	11	recently	recently	RB
cord-006702-ekf6mja9	349	12	identified	identify	VBN
cord-006702-ekf6mja9	349	13	several	several	JJ
cord-006702-ekf6mja9	349	14	urinary	urinary	JJ
cord-006702-ekf6mja9	349	15	proteins	protein	NNS
cord-006702-ekf6mja9	349	16	involved	involve	VBN
cord-006702-ekf6mja9	349	17	in	in	IN
cord-006702-ekf6mja9	349	18	lipid	lipid	NN
cord-006702-ekf6mja9	349	19	transport	transport	NN
cord-006702-ekf6mja9	349	20	and	and	CC
cord-006702-ekf6mja9	349	21	metabolism	metabolism	NN
cord-006702-ekf6mja9	349	22	in	in	IN
cord-006702-ekf6mja9	349	23	children	child	NNS
cord-006702-ekf6mja9	349	24	with	with	IN
cord-006702-ekf6mja9	349	25	nephrolithiasis	nephrolithiasis	NNP
cord-006702-ekf6mja9	349	26	and	and	CC
cord-006702-ekf6mja9	349	27	hypercalciuria	hypercalciuria	NNP
cord-006702-ekf6mja9	349	28	(	(	-LRB-
cord-006702-ekf6mja9	349	29	CAL	CAL	NNP
cord-006702-ekf6mja9	349	30	)	)	-RRB-
cord-006702-ekf6mja9	349	31	.	.	.
cord-006702-ekf6mja9	350	1	In	in	IN
cord-006702-ekf6mja9	350	2	the	the	DT
cord-006702-ekf6mja9	350	3	current	current	JJ
cord-006702-ekf6mja9	350	4	study	study	NN
cord-006702-ekf6mja9	350	5	,	,	,
cord-006702-ekf6mja9	350	6	we	-PRON-	PRP
cord-006702-ekf6mja9	350	7	aimed	aim	VBD
cord-006702-ekf6mja9	350	8	(	(	-LRB-
cord-006702-ekf6mja9	350	9	1	1	CD
cord-006702-ekf6mja9	350	10	)	)	-RRB-
cord-006702-ekf6mja9	350	11	to	to	TO
cord-006702-ekf6mja9	350	12	confirm	confirm	VB
cord-006702-ekf6mja9	350	13	these	these	DT
cord-006702-ekf6mja9	350	14	results	result	NNS
cord-006702-ekf6mja9	350	15	in	in	IN
cord-006702-ekf6mja9	350	16	individual	individual	JJ
cord-006702-ekf6mja9	350	17	samples	sample	NNS
cord-006702-ekf6mja9	350	18	by	by	IN
cord-006702-ekf6mja9	350	19	performing	perform	VBG
cord-006702-ekf6mja9	350	20	enzyme	enzyme	NN
cord-006702-ekf6mja9	350	21	-	-	HYPH
cord-006702-ekf6mja9	350	22	linked	link	VBN
cord-006702-ekf6mja9	350	23	immunosorbent	immunosorbent	JJ
cord-006702-ekf6mja9	350	24	assay	assay	NN
cord-006702-ekf6mja9	350	25	(	(	-LRB-
cord-006702-ekf6mja9	350	26	ELISA	ELISA	NNP
cord-006702-ekf6mja9	350	27	)	)	-RRB-
cord-006702-ekf6mja9	350	28	,	,	,
cord-006702-ekf6mja9	350	29	and	and	CC
cord-006702-ekf6mja9	350	30	(	(	-LRB-
cord-006702-ekf6mja9	350	31	2	2	LS
cord-006702-ekf6mja9	350	32	)	)	-RRB-
cord-006702-ekf6mja9	350	33	to	to	TO
cord-006702-ekf6mja9	350	34	examine	examine	VB
cord-006702-ekf6mja9	350	35	the	the	DT
cord-006702-ekf6mja9	350	36	relationship	relationship	NN
cord-006702-ekf6mja9	350	37	between	between	IN
cord-006702-ekf6mja9	350	38	the	the	DT
cord-006702-ekf6mja9	350	39	urinary	urinary	JJ
cord-006702-ekf6mja9	350	40	excretion	excretion	NN
cord-006702-ekf6mja9	350	41	of	of	IN
cord-006702-ekf6mja9	350	42	selected	select	VBN
cord-006702-ekf6mja9	350	43	proteins	protein	NNS
cord-006702-ekf6mja9	350	44	with	with	IN
cord-006702-ekf6mja9	350	45	demographic	demographic	JJ
cord-006702-ekf6mja9	350	46	,	,	,
cord-006702-ekf6mja9	350	47	dietary	dietary	JJ
cord-006702-ekf6mja9	350	48	,	,	,
cord-006702-ekf6mja9	350	49	blood	blood	NN
cord-006702-ekf6mja9	350	50	,	,	,
cord-006702-ekf6mja9	350	51	and	and	CC
cord-006702-ekf6mja9	350	52	urinary	urinary	JJ
cord-006702-ekf6mja9	350	53	parameters	parameter	NNS
cord-006702-ekf6mja9	350	54	.	.	.
cord-006702-ekf6mja9	351	1	Methods	method	NNS
cord-006702-ekf6mja9	351	2	:	:	:
cord-006702-ekf6mja9	351	3	Prospective	prospective	NN
cord-006702-ekf6mja9	351	4	,	,	,
cord-006702-ekf6mja9	351	5	controlled	control	VBN
cord-006702-ekf6mja9	351	6	,	,	,
cord-006702-ekf6mja9	351	7	pilot	pilot	NN
cord-006702-ekf6mja9	351	8	study	study	NN
cord-006702-ekf6mja9	351	9	comparing	compare	VBG
cord-006702-ekf6mja9	351	10	the	the	DT
cord-006702-ekf6mja9	351	11	urinary	urinary	JJ
cord-006702-ekf6mja9	351	12	excretion	excretion	NN
cord-006702-ekf6mja9	351	13	of	of	IN
cord-006702-ekf6mja9	351	14	Apolipoprotein	Apolipoprotein	NNP
cord-006702-ekf6mja9	351	15	A4	A4	NNP
cord-006702-ekf6mja9	351	16	(	(	-LRB-
cord-006702-ekf6mja9	351	17	ApoA4	ApoA4	NNP
cord-006702-ekf6mja9	351	18	)	)	-RRB-
cord-006702-ekf6mja9	351	19	,	,	,
cord-006702-ekf6mja9	351	20	Apolipoprotein	Apolipoprotein	NNP
cord-006702-ekf6mja9	351	21	C3	C3	NNP
cord-006702-ekf6mja9	351	22	(	(	-LRB-
cord-006702-ekf6mja9	351	23	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	351	24	)	)	-RRB-
cord-006702-ekf6mja9	351	25	,	,	,
cord-006702-ekf6mja9	351	26	and	and	CC
cord-006702-ekf6mja9	351	27	Fatty	fatty	JJ
cord-006702-ekf6mja9	351	28	Acid	acid	NN
cord-006702-ekf6mja9	351	29	-	-	HYPH
cord-006702-ekf6mja9	351	30	Binding	bind	VBG
cord-006702-ekf6mja9	351	31	Protein	Protein	NNP
cord-006702-ekf6mja9	351	32	1	1	CD
cord-006702-ekf6mja9	351	33	(	(	-LRB-
cord-006702-ekf6mja9	351	34	FABP1	FABP1	NNP
cord-006702-ekf6mja9	351	35	)	)	-RRB-
cord-006702-ekf6mja9	351	36	between	between	IN
cord-006702-ekf6mja9	351	37	CAL	CAL	NNP
cord-006702-ekf6mja9	351	38	(	(	-LRB-
cord-006702-ekf6mja9	351	39	N=16	N=16	NNP
cord-006702-ekf6mja9	351	40	,	,	,
cord-006702-ekf6mja9	351	41	9	9	CD
cord-006702-ekf6mja9	351	42	females	female	NNS
cord-006702-ekf6mja9	351	43	,	,	,
cord-006702-ekf6mja9	351	44	mean	mean	VB
cord-006702-ekf6mja9	351	45	age	age	NN
cord-006702-ekf6mja9	351	46	11.8+/-4.1	11.8+/-4.1	CD
cord-006702-ekf6mja9	351	47	years	year	NNS
cord-006702-ekf6mja9	351	48	)	)	-RRB-
cord-006702-ekf6mja9	351	49	,	,	,
cord-006702-ekf6mja9	351	50	and	and	CC
cord-006702-ekf6mja9	351	51	their	-PRON-	PRP$
cord-006702-ekf6mja9	351	52	age	age	NN
cord-006702-ekf6mja9	351	53	-	-	HYPH
cord-006702-ekf6mja9	351	54	and	and	CC
cord-006702-ekf6mja9	351	55	gender	gender	NN
cord-006702-ekf6mja9	351	56	-	-	HYPH
cord-006702-ekf6mja9	351	57	matched	match	VBN
cord-006702-ekf6mja9	351	58	healthy	healthy	JJ
cord-006702-ekf6mja9	351	59	controls	control	NNS
cord-006702-ekf6mja9	351	60	(	(	-LRB-
cord-006702-ekf6mja9	351	61	HC)(N=14)(ttest	HC)(N=14)(ttest	NNP
cord-006702-ekf6mja9	351	62	)	)	-RRB-
cord-006702-ekf6mja9	351	63	.	.	.
cord-006702-ekf6mja9	352	1	Exclusion	exclusion	NN
cord-006702-ekf6mja9	352	2	criteria	criterion	NNS
cord-006702-ekf6mja9	352	3	included	include	VBD
cord-006702-ekf6mja9	352	4	obese	obese	JJ
cord-006702-ekf6mja9	352	5	children	child	NNS
cord-006702-ekf6mja9	352	6	(	(	-LRB-
cord-006702-ekf6mja9	352	7	BMI>/=	BMI>/=	NFP
cord-006702-ekf6mja9	352	8	the	the	DT
cord-006702-ekf6mja9	352	9	95th	95th	JJ
cord-006702-ekf6mja9	352	10	percentile	percentile	NN
cord-006702-ekf6mja9	352	11	for	for	IN
cord-006702-ekf6mja9	352	12	children	child	NNS
cord-006702-ekf6mja9	352	13	of	of	IN
cord-006702-ekf6mja9	352	14	the	the	DT
cord-006702-ekf6mja9	352	15	same	same	JJ
cord-006702-ekf6mja9	352	16	age	age	NN
cord-006702-ekf6mja9	352	17	and	and	CC
cord-006702-ekf6mja9	352	18	sex	sex	NN
cord-006702-ekf6mja9	352	19	)	)	-RRB-
cord-006702-ekf6mja9	352	20	.	.	.
cord-006702-ekf6mja9	353	1	Results	result	NNS
cord-006702-ekf6mja9	353	2	:	:	:
cord-006702-ekf6mja9	354	1	Statistically	statistically	RB
cord-006702-ekf6mja9	354	2	significant	significant	JJ
cord-006702-ekf6mja9	354	3	increase	increase	NN
cord-006702-ekf6mja9	354	4	in	in	IN
cord-006702-ekf6mja9	354	5	the	the	DT
cord-006702-ekf6mja9	354	6	urinary	urinary	JJ
cord-006702-ekf6mja9	354	7	excretion	excretion	NN
cord-006702-ekf6mja9	354	8	of	of	IN
cord-006702-ekf6mja9	354	9	ApoA4	ApoA4	NNP
cord-006702-ekf6mja9	354	10	,	,	,
cord-006702-ekf6mja9	354	11	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	354	12	and	and	CC
cord-006702-ekf6mja9	354	13	FABP1	FABP1	NNP
cord-006702-ekf6mja9	354	14	in	in	IN
cord-006702-ekf6mja9	354	15	CAL	CAL	NNP
cord-006702-ekf6mja9	354	16	group	group	NN
cord-006702-ekf6mja9	354	17	vs	vs	IN
cord-006702-ekf6mja9	354	18	HC	HC	NNP
cord-006702-ekf6mja9	354	19	was	be	VBD
cord-006702-ekf6mja9	354	20	found	find	VBN
cord-006702-ekf6mja9	354	21	(	(	-LRB-
cord-006702-ekf6mja9	354	22	Table	table	NN
cord-006702-ekf6mja9	354	23	)	)	-RRB-
cord-006702-ekf6mja9	354	24	.	.	.
cord-006702-ekf6mja9	355	1	ApoA4	ApoA4	NNP
cord-006702-ekf6mja9	355	2	and	and	CC
cord-006702-ekf6mja9	355	3	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	355	4	levels	level	NNS
cord-006702-ekf6mja9	355	5	were	be	VBD
cord-006702-ekf6mja9	355	6	higher	high	JJR
cord-006702-ekf6mja9	355	7	in	in	IN
cord-006702-ekf6mja9	355	8	boys	boy	NNS
cord-006702-ekf6mja9	355	9	compared	compare	VBN
cord-006702-ekf6mja9	355	10	to	to	IN
cord-006702-ekf6mja9	355	11	girls	girl	NNS
cord-006702-ekf6mja9	355	12	.	.	.
cord-006702-ekf6mja9	356	1	In	in	IN
cord-006702-ekf6mja9	356	2	the	the	DT
cord-006702-ekf6mja9	356	3	CAL	CAL	NNP
cord-006702-ekf6mja9	356	4	group	group	NN
cord-006702-ekf6mja9	356	5	,	,	,
cord-006702-ekf6mja9	356	6	urinary	urinary	JJ
cord-006702-ekf6mja9	356	7	ApoA4	ApoA4	NNP
cord-006702-ekf6mja9	356	8	was	be	VBD
cord-006702-ekf6mja9	356	9	positively	positively	RB
cord-006702-ekf6mja9	356	10	correlated	correlate	VBN
cord-006702-ekf6mja9	356	11	with	with	IN
cord-006702-ekf6mja9	356	12	urinary	urinary	JJ
cord-006702-ekf6mja9	356	13	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	356	14	(	(	-LRB-
cord-006702-ekf6mja9	356	15	r=0.68	r=0.68	NNP
cord-006702-ekf6mja9	356	16	,	,	,
cord-006702-ekf6mja9	356	17	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	356	18	)	)	-RRB-
cord-006702-ekf6mja9	356	19	,	,	,
cord-006702-ekf6mja9	356	20	and	and	CC
cord-006702-ekf6mja9	356	21	intake	intake	NN
cord-006702-ekf6mja9	356	22	of	of	IN
cord-006702-ekf6mja9	356	23	meat	meat	NN
cord-006702-ekf6mja9	356	24	(	(	-LRB-
cord-006702-ekf6mja9	356	25	r=0.65	r=0.65	NNP
cord-006702-ekf6mja9	356	26	,	,	,
cord-006702-ekf6mja9	356	27	p<0.011	p<0.011	CD
cord-006702-ekf6mja9	356	28	)	)	-RRB-
cord-006702-ekf6mja9	356	29	.	.	.
cord-006702-ekf6mja9	357	1	24-hour	24-hour	JJ
cord-006702-ekf6mja9	357	2	urinary	urinary	JJ
cord-006702-ekf6mja9	357	3	calcium	calcium	NN
cord-006702-ekf6mja9	357	4	excretion	excretion	NN
cord-006702-ekf6mja9	357	5	significantly	significantly	RB
cord-006702-ekf6mja9	357	6	correlated	correlate	VBD
cord-006702-ekf6mja9	357	7	with	with	IN
cord-006702-ekf6mja9	357	8	concentrations	concentration	NNS
cord-006702-ekf6mja9	357	9	of	of	IN
cord-006702-ekf6mja9	357	10	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	357	11	(	(	-LRB-
cord-006702-ekf6mja9	357	12	r=0.77	r=0.77	NNP
cord-006702-ekf6mja9	357	13	,	,	,
cord-006702-ekf6mja9	357	14	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	357	15	)	)	-RRB-
cord-006702-ekf6mja9	357	16	,	,	,
cord-006702-ekf6mja9	357	17	and	and	CC
cord-006702-ekf6mja9	357	18	FABP1	FABP1	NNP
cord-006702-ekf6mja9	357	19	(	(	-LRB-
cord-006702-ekf6mja9	357	20	r=0.80	r=0.80	RB
cord-006702-ekf6mja9	357	21	,	,	,
cord-006702-ekf6mja9	357	22	p=0.005	p=0.005	ADD
cord-006702-ekf6mja9	357	23	)	)	-RRB-
cord-006702-ekf6mja9	357	24	.	.	.
cord-006702-ekf6mja9	358	1	&	&	CC
cord-006702-ekf6mja9	358	2	Apolipoprotein	Apolipoprotein	NNP
cord-006702-ekf6mja9	358	3	A4	A4	NNP
cord-006702-ekf6mja9	358	4	(	(	-LRB-
cord-006702-ekf6mja9	358	5	ApoA4	ApoA4	NNP
cord-006702-ekf6mja9	358	6	)	)	-RRB-
cord-006702-ekf6mja9	358	7	,	,	,
cord-006702-ekf6mja9	358	8	Apolipoprotein	Apolipoprotein	NNP
cord-006702-ekf6mja9	358	9	C3	C3	NNP
cord-006702-ekf6mja9	358	10	(	(	-LRB-
cord-006702-ekf6mja9	358	11	ApoC3	ApoC3	NNP
cord-006702-ekf6mja9	358	12	)	)	-RRB-
cord-006702-ekf6mja9	358	13	,	,	,
cord-006702-ekf6mja9	358	14	and	and	CC
cord-006702-ekf6mja9	358	15	Fatty	fatty	JJ
cord-006702-ekf6mja9	358	16	Acid	acid	NN
cord-006702-ekf6mja9	358	17	-	-	HYPH
cord-006702-ekf6mja9	358	18	Binding	bind	VBG
cord-006702-ekf6mja9	358	19	Protein	Protein	NNP
cord-006702-ekf6mja9	358	20	1	1	CD
cord-006702-ekf6mja9	358	21	(	(	-LRB-
cord-006702-ekf6mja9	358	22	FABP1	FABP1	NNS
cord-006702-ekf6mja9	358	23	)	)	-RRB-
cord-006702-ekf6mja9	359	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	359	2	:	:	:
cord-006702-ekf6mja9	360	1	We	-PRON-	PRP
cord-006702-ekf6mja9	360	2	found	find	VBD
cord-006702-ekf6mja9	360	3	marked	marked	JJ
cord-006702-ekf6mja9	360	4	increase	increase	NN
cord-006702-ekf6mja9	360	5	in	in	IN
cord-006702-ekf6mja9	360	6	urinary	urinary	JJ
cord-006702-ekf6mja9	360	7	excretion	excretion	NN
cord-006702-ekf6mja9	360	8	of	of	IN
cord-006702-ekf6mja9	360	9	lipid	lipid	NN
cord-006702-ekf6mja9	360	10	metabolism	metabolism	NN
cord-006702-ekf6mja9	360	11	/	/	SYM
cord-006702-ekf6mja9	360	12	transport	transport	NN
cord-006702-ekf6mja9	360	13	-	-	HYPH
cord-006702-ekf6mja9	360	14	related	relate	VBN
cord-006702-ekf6mja9	360	15	proteins	protein	NNS
cord-006702-ekf6mja9	360	16	in	in	IN
cord-006702-ekf6mja9	360	17	non	non	JJ
cord-006702-ekf6mja9	360	18	-	-	JJ
cord-006702-ekf6mja9	360	19	obese	obese	JJ
cord-006702-ekf6mja9	360	20	children	child	NNS
cord-006702-ekf6mja9	360	21	with	with	IN
cord-006702-ekf6mja9	360	22	nephrolithiasis	nephrolithiasis	NNP
cord-006702-ekf6mja9	360	23	and	and	CC
cord-006702-ekf6mja9	360	24	hypercalciuria	hypercalciuria	NNP
cord-006702-ekf6mja9	360	25	.	.	.
cord-006702-ekf6mja9	361	1	These	these	DT
cord-006702-ekf6mja9	361	2	findings	finding	NNS
cord-006702-ekf6mja9	361	3	suggest	suggest	VBP
cord-006702-ekf6mja9	361	4	that	that	IN
cord-006702-ekf6mja9	361	5	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	361	6	in	in	IN
cord-006702-ekf6mja9	361	7	lipid	lipid	NN
cord-006702-ekf6mja9	361	8	metabolism	metabolism	NN
cord-006702-ekf6mja9	361	9	may	may	MD
cord-006702-ekf6mja9	361	10	play	play	VB
cord-006702-ekf6mja9	361	11	an	an	DT
cord-006702-ekf6mja9	361	12	important	important	JJ
cord-006702-ekf6mja9	361	13	role	role	NN
cord-006702-ekf6mja9	361	14	in	in	IN
cord-006702-ekf6mja9	361	15	nephrolithiasis	nephrolithiasis	NN
cord-006702-ekf6mja9	361	16	.	.	.
cord-006702-ekf6mja9	362	1	Targeting	target	VBG
cord-006702-ekf6mja9	362	2	these	these	DT
cord-006702-ekf6mja9	362	3	proteins	protein	NNS
cord-006702-ekf6mja9	362	4	may	may	MD
cord-006702-ekf6mja9	362	5	have	have	VB
cord-006702-ekf6mja9	362	6	preventive	preventive	JJ
cord-006702-ekf6mja9	362	7	and	and	CC
cord-006702-ekf6mja9	362	8	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	362	9	benefits	benefit	NNS
cord-006702-ekf6mja9	362	10	.	.	.
cord-006702-ekf6mja9	363	1	Objectives	objective	NNS
cord-006702-ekf6mja9	363	2	:	:	:
cord-006702-ekf6mja9	363	3	Single	single	JJ
cord-006702-ekf6mja9	363	4	center	center	NN
cord-006702-ekf6mja9	363	5	studies	study	NNS
cord-006702-ekf6mja9	363	6	report	report	VBP
cord-006702-ekf6mja9	363	7	neonatal	neonatal	JJ
cord-006702-ekf6mja9	363	8	acute	acute	JJ
cord-006702-ekf6mja9	363	9	kidney	kidney	NN
cord-006702-ekf6mja9	363	10	injury	injury	NN
cord-006702-ekf6mja9	363	11	(	(	-LRB-
cord-006702-ekf6mja9	363	12	AKI	AKI	NNP
cord-006702-ekf6mja9	363	13	)	)	-RRB-
cord-006702-ekf6mja9	363	14	incidence	incidence	NN
cord-006702-ekf6mja9	363	15	of	of	IN
cord-006702-ekf6mja9	363	16	12	12	CD
cord-006702-ekf6mja9	363	17	-	-	SYM
cord-006702-ekf6mja9	363	18	70	70	CD
cord-006702-ekf6mja9	363	19	%	%	NN
cord-006702-ekf6mja9	363	20	;	;	,
cord-006702-ekf6mja9	363	21	neonates	neonate	NNS
cord-006702-ekf6mja9	363	22	with	with	IN
cord-006702-ekf6mja9	363	23	AKI	AKI	NNP
cord-006702-ekf6mja9	363	24	appear	appear	VBP
cord-006702-ekf6mja9	363	25	to	to	TO
cord-006702-ekf6mja9	363	26	have	have	VB
cord-006702-ekf6mja9	363	27	worse	bad	JJR
cord-006702-ekf6mja9	363	28	outcomes	outcome	NNS
cord-006702-ekf6mja9	363	29	.	.	.
cord-006702-ekf6mja9	364	1	These	these	DT
cord-006702-ekf6mja9	364	2	findings	finding	NNS
cord-006702-ekf6mja9	364	3	prompted	prompt	VBD
cord-006702-ekf6mja9	364	4	the	the	DT
cord-006702-ekf6mja9	364	5	formation	formation	NN
cord-006702-ekf6mja9	364	6	of	of	IN
cord-006702-ekf6mja9	364	7	the	the	DT
cord-006702-ekf6mja9	364	8	Neonatal	Neonatal	NNP
cord-006702-ekf6mja9	364	9	Kidney	Kidney	NNP
cord-006702-ekf6mja9	364	10	Collaborative	Collaborative	NNP
cord-006702-ekf6mja9	364	11	(	(	-LRB-
cord-006702-ekf6mja9	364	12	NKC	NKC	NNP
cord-006702-ekf6mja9	364	13	)	)	-RRB-
cord-006702-ekf6mja9	364	14	and	and	CC
cord-006702-ekf6mja9	364	15	the	the	DT
cord-006702-ekf6mja9	364	16	development	development	NN
cord-006702-ekf6mja9	364	17	and	and	CC
cord-006702-ekf6mja9	364	18	implementation	implementation	NN
cord-006702-ekf6mja9	364	19	of	of	IN
cord-006702-ekf6mja9	364	20	the	the	DT
cord-006702-ekf6mja9	364	21	AWAKEN	AWAKEN	NNP
cord-006702-ekf6mja9	364	22	study	study	NN
cord-006702-ekf6mja9	364	23	.	.	.
cord-006702-ekf6mja9	365	1	The	the	DT
cord-006702-ekf6mja9	365	2	objective	objective	NN
cord-006702-ekf6mja9	365	3	of	of	IN
cord-006702-ekf6mja9	365	4	this	this	DT
cord-006702-ekf6mja9	365	5	study	study	NN
cord-006702-ekf6mja9	365	6	is	be	VBZ
cord-006702-ekf6mja9	365	7	to	to	TO
cord-006702-ekf6mja9	365	8	assess	assess	VB
cord-006702-ekf6mja9	365	9	the	the	DT
cord-006702-ekf6mja9	365	10	incidence	incidence	NN
cord-006702-ekf6mja9	365	11	of	of	IN
cord-006702-ekf6mja9	365	12	neonatal	neonatal	JJ
cord-006702-ekf6mja9	365	13	AKI	AKI	NNP
cord-006702-ekf6mja9	365	14	and	and	CC
cord-006702-ekf6mja9	365	15	its	-PRON-	PRP$
cord-006702-ekf6mja9	365	16	association	association	NN
cord-006702-ekf6mja9	365	17	with	with	IN
cord-006702-ekf6mja9	365	18	outcomes	outcome	NNS
cord-006702-ekf6mja9	365	19	in	in	IN
cord-006702-ekf6mja9	365	20	a	a	DT
cord-006702-ekf6mja9	365	21	large	large	JJ
cord-006702-ekf6mja9	365	22	,	,	,
cord-006702-ekf6mja9	365	23	multi	multi	JJ
cord-006702-ekf6mja9	365	24	-	-	JJ
cord-006702-ekf6mja9	365	25	national	national	JJ
cord-006702-ekf6mja9	365	26	cohort	cohort	NN
cord-006702-ekf6mja9	365	27	Methods	method	NNS
cord-006702-ekf6mja9	365	28	:	:	:
cord-006702-ekf6mja9	365	29	NKC	NKC	NNP
cord-006702-ekf6mja9	365	30	includes	include	VBZ
cord-006702-ekf6mja9	365	31	24	24	CD
cord-006702-ekf6mja9	365	32	institutions	institution	NNS
cord-006702-ekf6mja9	365	33	from	from	IN
cord-006702-ekf6mja9	365	34	4	4	CD
cord-006702-ekf6mja9	365	35	countries	country	NNS
cord-006702-ekf6mja9	365	36	(	(	-LRB-
cord-006702-ekf6mja9	365	37	USA	USA	NNP
cord-006702-ekf6mja9	365	38	,	,	,
cord-006702-ekf6mja9	365	39	Canada	Canada	NNP
cord-006702-ekf6mja9	365	40	,	,	,
cord-006702-ekf6mja9	365	41	Australia	Australia	NNP
cord-006702-ekf6mja9	365	42	and	and	CC
cord-006702-ekf6mja9	365	43	India	India	NNP
cord-006702-ekf6mja9	365	44	)	)	-RRB-
cord-006702-ekf6mja9	365	45	.	.	.
cord-006702-ekf6mja9	366	1	Neonatal	neonatal	JJ
cord-006702-ekf6mja9	366	2	intensive	intensive	JJ
cord-006702-ekf6mja9	366	3	care	care	NN
cord-006702-ekf6mja9	366	4	unit	unit	NN
cord-006702-ekf6mja9	366	5	(	(	-LRB-
cord-006702-ekf6mja9	366	6	NICU	NICU	NNP
cord-006702-ekf6mja9	366	7	)	)	-RRB-
cord-006702-ekf6mja9	366	8	admissions	admission	NNS
cord-006702-ekf6mja9	366	9	from	from	IN
cord-006702-ekf6mja9	366	10	Jan	Jan	NNP
cord-006702-ekf6mja9	366	11	1	1	CD
cord-006702-ekf6mja9	366	12	to	to	IN
cord-006702-ekf6mja9	366	13	Mar	Mar	NNP
cord-006702-ekf6mja9	366	14	31	31	CD
cord-006702-ekf6mja9	366	15	,	,	,
cord-006702-ekf6mja9	366	16	2014	2014	CD
cord-006702-ekf6mja9	366	17	were	be	VBD
cord-006702-ekf6mja9	366	18	screened	screen	VBN
cord-006702-ekf6mja9	366	19	.	.	.
cord-006702-ekf6mja9	367	1	Inclusion	inclusion	NN
cord-006702-ekf6mja9	367	2	criteria	criterion	NNS
cord-006702-ekf6mja9	367	3	need	need	VBP
cord-006702-ekf6mja9	367	4	for	for	IN
cord-006702-ekf6mja9	367	5	intravenous	intravenous	JJ
cord-006702-ekf6mja9	367	6	(	(	-LRB-
cord-006702-ekf6mja9	367	7	IV	IV	NNP
cord-006702-ekf6mja9	367	8	)	)	-RRB-
cord-006702-ekf6mja9	367	9	fluids	fluid	VBZ
cord-006702-ekf6mja9	367	10	≥48	≥48	NNP
cord-006702-ekf6mja9	367	11	hrs	hrs	NN
cord-006702-ekf6mja9	367	12	.	.	.
cord-006702-ekf6mja9	368	1	Exclusion	exclusion	NN
cord-006702-ekf6mja9	368	2	criteria	criterion	NNS
cord-006702-ekf6mja9	368	3	:	:	:
cord-006702-ekf6mja9	369	1	1	1	LS
cord-006702-ekf6mja9	369	2	)	)	-RRB-
cord-006702-ekf6mja9	369	3	admission	admission	NN
cord-006702-ekf6mja9	369	4	at	at	IN
cord-006702-ekf6mja9	369	5	>	>	XX
cord-006702-ekf6mja9	369	6	2	2	CD
cord-006702-ekf6mja9	369	7	weeks	week	NNS
cord-006702-ekf6mja9	369	8	of	of	IN
cord-006702-ekf6mja9	369	9	age	age	NN
cord-006702-ekf6mja9	369	10	,	,	,
cord-006702-ekf6mja9	369	11	2	2	CD
cord-006702-ekf6mja9	369	12	)	)	-RRB-
cord-006702-ekf6mja9	369	13	congenital	congenital	JJ
cord-006702-ekf6mja9	369	14	heart	heart	NN
cord-006702-ekf6mja9	369	15	disease	disease	NN
cord-006702-ekf6mja9	369	16	requiring	require	VBG
cord-006702-ekf6mja9	369	17	surgical	surgical	JJ
cord-006702-ekf6mja9	369	18	repair	repair	NN
cord-006702-ekf6mja9	369	19	at	at	IN
cord-006702-ekf6mja9	369	20	<	<	XX
cord-006702-ekf6mja9	369	21	7	7	CD
cord-006702-ekf6mja9	369	22	days	day	NNS
cord-006702-ekf6mja9	369	23	of	of	IN
cord-006702-ekf6mja9	369	24	age	age	NN
cord-006702-ekf6mja9	369	25	,	,	,
cord-006702-ekf6mja9	369	26	3	3	CD
cord-006702-ekf6mja9	369	27	)	)	-RRB-
cord-006702-ekf6mja9	369	28	lethal	lethal	JJ
cord-006702-ekf6mja9	369	29	chromosomal	chromosomal	JJ
cord-006702-ekf6mja9	369	30	anomaly	anomaly	NN
cord-006702-ekf6mja9	369	31	,	,	,
cord-006702-ekf6mja9	369	32	4	4	CD
cord-006702-ekf6mja9	369	33	)	)	-RRB-
cord-006702-ekf6mja9	369	34	death	death	NN
cord-006702-ekf6mja9	369	35	within	within	IN
cord-006702-ekf6mja9	369	36	48	48	CD
cord-006702-ekf6mja9	369	37	hours	hour	NNS
cord-006702-ekf6mja9	369	38	of	of	IN
cord-006702-ekf6mja9	369	39	admission	admission	NN
cord-006702-ekf6mja9	369	40	,	,	,
cord-006702-ekf6mja9	369	41	5	5	CD
cord-006702-ekf6mja9	369	42	)	)	-RRB-
cord-006702-ekf6mja9	369	43	severe	severe	JJ
cord-006702-ekf6mja9	369	44	congenital	congenital	JJ
cord-006702-ekf6mja9	369	45	kidney	kidney	NN
cord-006702-ekf6mja9	369	46	disease	disease	NN
cord-006702-ekf6mja9	369	47	.	.	.
cord-006702-ekf6mja9	370	1	AKI	AKI	NNP
cord-006702-ekf6mja9	370	2	was	be	VBD
cord-006702-ekf6mja9	370	3	defined	define	VBN
cord-006702-ekf6mja9	370	4	as	as	IN
cord-006702-ekf6mja9	370	5	either	either	DT
cord-006702-ekf6mja9	370	6	urine	urine	NN
cord-006702-ekf6mja9	370	7	output	output	NN
cord-006702-ekf6mja9	370	8	(	(	-LRB-
cord-006702-ekf6mja9	370	9	UOP	UOP	NNP
cord-006702-ekf6mja9	370	10	)	)	-RRB-
cord-006702-ekf6mja9	371	1	<	<	XX
cord-006702-ekf6mja9	371	2	1	1	CD
cord-006702-ekf6mja9	371	3	mL/	mL/	NNP
cord-006702-ekf6mja9	371	4	kg	kg	NNP
cord-006702-ekf6mja9	371	5	/	/	SYM
cord-006702-ekf6mja9	371	6	hr	hr	NN
cord-006702-ekf6mja9	371	7	during	during	IN
cord-006702-ekf6mja9	371	8	any	any	DT
cord-006702-ekf6mja9	371	9	24	24	CD
cord-006702-ekf6mja9	371	10	hour	hour	NN
cord-006702-ekf6mja9	371	11	period	period	NN
cord-006702-ekf6mja9	371	12	from	from	IN
cord-006702-ekf6mja9	371	13	days	day	NNS
cord-006702-ekf6mja9	371	14	2	2	CD
cord-006702-ekf6mja9	371	15	-	-	SYM
cord-006702-ekf6mja9	371	16	7	7	CD
cord-006702-ekf6mja9	371	17	of	of	IN
cord-006702-ekf6mja9	371	18	life	life	NN
cord-006702-ekf6mja9	371	19	,	,	,
cord-006702-ekf6mja9	371	20	a	a	DT
cord-006702-ekf6mja9	371	21	rise	rise	NN
cord-006702-ekf6mja9	371	22	in	in	IN
cord-006702-ekf6mja9	371	23	serum	serum	NN
cord-006702-ekf6mja9	371	24	creatinine	creatinine	NN
cord-006702-ekf6mja9	371	25	(	(	-LRB-
cord-006702-ekf6mja9	371	26	SCr	SCr	NNP
cord-006702-ekf6mja9	371	27	)	)	-RRB-
cord-006702-ekf6mja9	371	28	of	of	IN
cord-006702-ekf6mja9	371	29	0.3	0.3	CD
cord-006702-ekf6mja9	371	30	mg	mg	NNP
cord-006702-ekf6mja9	371	31	/	/	SYM
cord-006702-ekf6mja9	371	32	dL	dl	NN
cord-006702-ekf6mja9	371	33	from	from	IN
cord-006702-ekf6mja9	371	34	previous	previous	JJ
cord-006702-ekf6mja9	371	35	lowest	low	JJS
cord-006702-ekf6mja9	371	36	value	value	NN
cord-006702-ekf6mja9	371	37	and/or	and/or	CC
cord-006702-ekf6mja9	371	38	receipt	receipt	NN
cord-006702-ekf6mja9	371	39	of	of	IN
cord-006702-ekf6mja9	371	40	renal	renal	JJ
cord-006702-ekf6mja9	371	41	replacement	replacement	NN
cord-006702-ekf6mja9	371	42	therapy	therapy	NN
cord-006702-ekf6mja9	371	43	.	.	.
cord-006702-ekf6mja9	372	1	(	(	-LRB-
cord-006702-ekf6mja9	372	2	Table	table	NN
cord-006702-ekf6mja9	372	3	)	)	-RRB-
cord-006702-ekf6mja9	373	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	373	2	:	:	:
cord-006702-ekf6mja9	374	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	374	2	study	study	NN
cord-006702-ekf6mja9	374	3	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	374	4	that	that	IN
cord-006702-ekf6mja9	374	5	at	at	RB
cord-006702-ekf6mja9	374	6	least	least	RBS
cord-006702-ekf6mja9	374	7	35.4	35.4	CD
cord-006702-ekf6mja9	374	8	%	%	NN
cord-006702-ekf6mja9	374	9	of	of	IN
cord-006702-ekf6mja9	374	10	infants	infant	NNS
cord-006702-ekf6mja9	374	11	admitted	admit	VBN
cord-006702-ekf6mja9	374	12	to	to	IN
cord-006702-ekf6mja9	374	13	NICU	NICU	NNP
cord-006702-ekf6mja9	374	14	who	who	WP
cord-006702-ekf6mja9	374	15	required	require	VBD
cord-006702-ekf6mja9	374	16	IV	IV	NNP
cord-006702-ekf6mja9	374	17	fluids	fluid	NNS
cord-006702-ekf6mja9	374	18	develop	develop	VBP
cord-006702-ekf6mja9	374	19	AKI	AKI	NNP
cord-006702-ekf6mja9	374	20	.	.	.
cord-006702-ekf6mja9	375	1	Subjects	subject	NNS
cord-006702-ekf6mja9	375	2	with	with	IN
cord-006702-ekf6mja9	375	3	AKI	AKI	NNP
cord-006702-ekf6mja9	375	4	have	have	VBP
cord-006702-ekf6mja9	375	5	worse	bad	JJR
cord-006702-ekf6mja9	375	6	increased	increase	VBN
cord-006702-ekf6mja9	375	7	risk	risk	NN
cord-006702-ekf6mja9	375	8	of	of	IN
cord-006702-ekf6mja9	375	9	death	death	NN
cord-006702-ekf6mja9	375	10	and	and	CC
cord-006702-ekf6mja9	375	11	longer	long	RBR
cord-006702-ekf6mja9	375	12	LOS	LOS	NNP
cord-006702-ekf6mja9	375	13	.	.	.
cord-006702-ekf6mja9	376	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	376	2	data	datum	NNS
cord-006702-ekf6mja9	376	3	contribute	contribute	VBP
cord-006702-ekf6mja9	376	4	to	to	IN
cord-006702-ekf6mja9	376	5	the	the	DT
cord-006702-ekf6mja9	376	6	growing	grow	VBG
cord-006702-ekf6mja9	376	7	evidence	evidence	NN
cord-006702-ekf6mja9	376	8	that	that	IN
cord-006702-ekf6mja9	376	9	neonatal	neonatal	JJ
cord-006702-ekf6mja9	376	10	AKI	AKI	NNP
cord-006702-ekf6mja9	376	11	is	be	VBZ
cord-006702-ekf6mja9	376	12	common	common	JJ
cord-006702-ekf6mja9	376	13	,	,	,
cord-006702-ekf6mja9	376	14	with	with	IN
cord-006702-ekf6mja9	376	15	significant	significant	JJ
cord-006702-ekf6mja9	376	16	impact	impact	NN
cord-006702-ekf6mja9	376	17	on	on	IN
cord-006702-ekf6mja9	376	18	clinical	clinical	JJ
cord-006702-ekf6mja9	376	19	outcomes	outcome	NNS
cord-006702-ekf6mja9	376	20	.	.	.
cord-006702-ekf6mja9	377	1	Further	further	JJ
cord-006702-ekf6mja9	377	2	analysis	analysis	NN
cord-006702-ekf6mja9	377	3	of	of	IN
cord-006702-ekf6mja9	377	4	this	this	DT
cord-006702-ekf6mja9	377	5	robust	robust	JJ
cord-006702-ekf6mja9	377	6	database	database	NN
cord-006702-ekf6mja9	377	7	is	be	VBZ
cord-006702-ekf6mja9	377	8	underway	underway	JJ
cord-006702-ekf6mja9	377	9	.	.	.
cord-006702-ekf6mja9	378	1	FP	FP	NNP
cord-006702-ekf6mja9	378	2	-	-	HYPH
cord-006702-ekf6mja9	378	3	S13	S13	NNP
cord-006702-ekf6mja9	378	4	-	-	HYPH
cord-006702-ekf6mja9	378	5	2	2	CD
cord-006702-ekf6mja9	379	1	The	the	DT
cord-006702-ekf6mja9	379	2	follow	follow	NN
cord-006702-ekf6mja9	379	3	up	up	RP
cord-006702-ekf6mja9	379	4	and	and	CC
cord-006702-ekf6mja9	379	5	outcome	outcome	NN
cord-006702-ekf6mja9	379	6	of	of	IN
cord-006702-ekf6mja9	379	7	children	child	NNS
cord-006702-ekf6mja9	379	8	requiring	require	VBG
cord-006702-ekf6mja9	379	9	renal	renal	JJ
cord-006702-ekf6mja9	379	10	replacement	replacement	NN
cord-006702-ekf6mja9	379	11	therapy	therapy	NN
cord-006702-ekf6mja9	379	12	for	for	IN
cord-006702-ekf6mja9	379	13	acute	acute	JJ
cord-006702-ekf6mja9	379	14	kidney	kidney	NN
cord-006702-ekf6mja9	379	15	injury	injury	NN
cord-006702-ekf6mja9	379	16	following	follow	VBG
cord-006702-ekf6mja9	379	17	cardiac	cardiac	JJ
cord-006702-ekf6mja9	379	18	surgery	surgery	NN
cord-006702-ekf6mja9	379	19	in	in	IN
cord-006702-ekf6mja9	379	20	New	New	NNP
cord-006702-ekf6mja9	379	21	Zealand	Zealand	NNP
cord-006702-ekf6mja9	379	22	C.	C.	NNP
cord-006702-ekf6mja9	379	23	Chan	Chan	NNP
cord-006702-ekf6mja9	379	24	,	,	,
cord-006702-ekf6mja9	379	25	T.	T.	NNP
cord-006702-ekf6mja9	379	26	Kara	Kara	NNP
cord-006702-ekf6mja9	379	27	Starship	Starship	NNP
cord-006702-ekf6mja9	379	28	Children	Children	NNPS
cord-006702-ekf6mja9	379	29	's	's	POS
cord-006702-ekf6mja9	379	30	Hospital	Hospital	NNP
cord-006702-ekf6mja9	379	31	,	,	,
cord-006702-ekf6mja9	379	32	Auckland	Auckland	NNP
cord-006702-ekf6mja9	379	33	District	District	NNP
cord-006702-ekf6mja9	379	34	Health	Health	NNP
cord-006702-ekf6mja9	379	35	Board	Board	NNP
cord-006702-ekf6mja9	379	36	,	,	,
cord-006702-ekf6mja9	379	37	Auckland	Auckland	NNP
cord-006702-ekf6mja9	379	38	,	,	,
cord-006702-ekf6mja9	379	39	New	New	NNP
cord-006702-ekf6mja9	379	40	Zealand	Zealand	NNP
cord-006702-ekf6mja9	379	41	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	379	42	:	:	:
cord-006702-ekf6mja9	380	1	To	to	TO
cord-006702-ekf6mja9	380	2	examine	examine	VB
cord-006702-ekf6mja9	380	3	the	the	DT
cord-006702-ekf6mja9	380	4	characteristics	characteristic	NNS
cord-006702-ekf6mja9	380	5	,	,	,
cord-006702-ekf6mja9	380	6	follow	follow	VB
cord-006702-ekf6mja9	380	7	up	up	RP
cord-006702-ekf6mja9	380	8	and	and	CC
cord-006702-ekf6mja9	380	9	availability	availability	NN
cord-006702-ekf6mja9	380	10	of	of	IN
cord-006702-ekf6mja9	380	11	long	long	JJ
cord-006702-ekf6mja9	380	12	term	term	NN
cord-006702-ekf6mja9	380	13	outcome	outcome	NN
cord-006702-ekf6mja9	380	14	data	datum	NNS
cord-006702-ekf6mja9	380	15	in	in	IN
cord-006702-ekf6mja9	380	16	a	a	DT
cord-006702-ekf6mja9	380	17	cohort	cohort	NN
cord-006702-ekf6mja9	380	18	of	of	IN
cord-006702-ekf6mja9	380	19	New	New	NNP
cord-006702-ekf6mja9	380	20	Zealand	Zealand	NNP
cord-006702-ekf6mja9	380	21	children	child	NNS
cord-006702-ekf6mja9	380	22	with	with	IN
cord-006702-ekf6mja9	380	23	acute	acute	JJ
cord-006702-ekf6mja9	380	24	kidney	kidney	NN
cord-006702-ekf6mja9	380	25	injury	injury	NN
cord-006702-ekf6mja9	380	26	(	(	-LRB-
cord-006702-ekf6mja9	380	27	AKI	AKI	NNP
cord-006702-ekf6mja9	380	28	)	)	-RRB-
cord-006702-ekf6mja9	380	29	requiring	require	VBG
cord-006702-ekf6mja9	380	30	renal	renal	JJ
cord-006702-ekf6mja9	380	31	replacement	replacement	NN
cord-006702-ekf6mja9	380	32	therapy	therapy	NN
cord-006702-ekf6mja9	380	33	(	(	-LRB-
cord-006702-ekf6mja9	380	34	RRT	RRT	NNP
cord-006702-ekf6mja9	380	35	)	)	-RRB-
cord-006702-ekf6mja9	380	36	following	follow	VBG
cord-006702-ekf6mja9	380	37	cardiac	cardiac	JJ
cord-006702-ekf6mja9	380	38	surgery	surgery	NN
cord-006702-ekf6mja9	380	39	at	at	IN
cord-006702-ekf6mja9	380	40	Starship	Starship	NNP
cord-006702-ekf6mja9	380	41	Hospital	Hospital	NNP
cord-006702-ekf6mja9	380	42	over	over	IN
cord-006702-ekf6mja9	380	43	a	a	DT
cord-006702-ekf6mja9	380	44	six	six	CD
cord-006702-ekf6mja9	380	45	-	-	HYPH
cord-006702-ekf6mja9	380	46	year	year	NN
cord-006702-ekf6mja9	380	47	period	period	NN
cord-006702-ekf6mja9	380	48	.	.	.
cord-006702-ekf6mja9	381	1	Methods	method	NNS
cord-006702-ekf6mja9	381	2	:	:	:
cord-006702-ekf6mja9	382	1	The	the	DT
cord-006702-ekf6mja9	382	2	cohort	cohort	NN
cord-006702-ekf6mja9	382	3	used	use	VBD
cord-006702-ekf6mja9	382	4	was	be	VBD
cord-006702-ekf6mja9	382	5	identified	identify	VBN
cord-006702-ekf6mja9	382	6	in	in	IN
cord-006702-ekf6mja9	382	7	the	the	DT
cord-006702-ekf6mja9	382	8	previously	previously	RB
cord-006702-ekf6mja9	382	9	published	publish	VBN
cord-006702-ekf6mja9	382	10	"	"	``
cord-006702-ekf6mja9	382	11	Epidemiology	epidemiology	NN
cord-006702-ekf6mja9	382	12	and	and	CC
cord-006702-ekf6mja9	382	13	outcome	outcome	NN
cord-006702-ekf6mja9	382	14	of	of	IN
cord-006702-ekf6mja9	382	15	acute	acute	JJ
cord-006702-ekf6mja9	382	16	kidney	kidney	NN
cord-006702-ekf6mja9	382	17	injury	injury	NN
cord-006702-ekf6mja9	382	18	in	in	IN
cord-006702-ekf6mja9	382	19	New	New	NNP
cord-006702-ekf6mja9	382	20	Zealand	Zealand	NNP
cord-006702-ekf6mja9	382	21	children	child	NNS
cord-006702-ekf6mja9	382	22	"	"	''
cord-006702-ekf6mja9	382	23	.	.	.
cord-006702-ekf6mja9	383	1	Aretrospective	aretrospective	JJ
cord-006702-ekf6mja9	383	2	review	review	NN
cord-006702-ekf6mja9	383	3	of	of	IN
cord-006702-ekf6mja9	383	4	medical	medical	JJ
cord-006702-ekf6mja9	383	5	records	record	NNS
cord-006702-ekf6mja9	383	6	of	of	IN
cord-006702-ekf6mja9	383	7	all	all	PDT
cord-006702-ekf6mja9	383	8	the	the	DT
cord-006702-ekf6mja9	383	9	children	child	NNS
cord-006702-ekf6mja9	383	10	requiring	require	VBG
cord-006702-ekf6mja9	383	11	RRT	RRT	NNP
cord-006702-ekf6mja9	383	12	for	for	IN
cord-006702-ekf6mja9	383	13	AKI	AKI	NNP
cord-006702-ekf6mja9	383	14	following	follow	VBG
cord-006702-ekf6mja9	383	15	cardiac	cardiac	JJ
cord-006702-ekf6mja9	383	16	surgery	surgery	NN
cord-006702-ekf6mja9	383	17	from	from	IN
cord-006702-ekf6mja9	383	18	January	January	NNP
cord-006702-ekf6mja9	383	19	2001	2001	CD
cord-006702-ekf6mja9	383	20	to	to	IN
cord-006702-ekf6mja9	383	21	December	December	NNP
cord-006702-ekf6mja9	383	22	2006	2006	CD
cord-006702-ekf6mja9	383	23	was	be	VBD
cord-006702-ekf6mja9	383	24	repeated	repeat	VBN
cord-006702-ekf6mja9	383	25	to	to	TO
cord-006702-ekf6mja9	383	26	add	add	VB
cord-006702-ekf6mja9	383	27	further	further	JJ
cord-006702-ekf6mja9	383	28	data	datum	NNS
cord-006702-ekf6mja9	383	29	regarding	regard	VBG
cord-006702-ekf6mja9	383	30	their	-PRON-	PRP$
cord-006702-ekf6mja9	383	31	cardiac	cardiac	JJ
cord-006702-ekf6mja9	383	32	history	history	NN
cord-006702-ekf6mja9	383	33	.	.	.
cord-006702-ekf6mja9	384	1	Patient	patient	JJ
cord-006702-ekf6mja9	384	2	characteristics	characteristic	NNS
cord-006702-ekf6mja9	384	3	were	be	VBD
cord-006702-ekf6mja9	384	4	summarised	summarise	VBN
cord-006702-ekf6mja9	384	5	.	.	.
cord-006702-ekf6mja9	385	1	Primary	primary	JJ
cord-006702-ekf6mja9	385	2	outcome	outcome	NN
cord-006702-ekf6mja9	385	3	was	be	VBD
cord-006702-ekf6mja9	385	4	rates	rate	NNS
cord-006702-ekf6mja9	385	5	of	of	IN
cord-006702-ekf6mja9	385	6	renal	renal	JJ
cord-006702-ekf6mja9	385	7	surveillance	surveillance	NN
cord-006702-ekf6mja9	385	8	.	.	.
cord-006702-ekf6mja9	386	1	Evidence	evidence	NN
cord-006702-ekf6mja9	386	2	of	of	IN
cord-006702-ekf6mja9	386	3	renal	renal	JJ
cord-006702-ekf6mja9	386	4	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	386	5	and	and	CC
cord-006702-ekf6mja9	386	6	possible	possible	JJ
cord-006702-ekf6mja9	386	7	contributing	contributing	NN
cord-006702-ekf6mja9	386	8	factors	factor	NNS
cord-006702-ekf6mja9	386	9	were	be	VBD
cord-006702-ekf6mja9	386	10	also	also	RB
cord-006702-ekf6mja9	386	11	studied	study	VBN
cord-006702-ekf6mja9	386	12	.	.	.
cord-006702-ekf6mja9	386	13	 	 	_SP
cord-006702-ekf6mja9	387	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	387	2	:	:	:
cord-006702-ekf6mja9	388	1	This	this	DT
cord-006702-ekf6mja9	388	2	study	study	NN
cord-006702-ekf6mja9	388	3	suggests	suggest	VBZ
cord-006702-ekf6mja9	388	4	that	that	IN
cord-006702-ekf6mja9	388	5	a	a	DT
cord-006702-ekf6mja9	388	6	proportion	proportion	NN
cord-006702-ekf6mja9	388	7	of	of	IN
cord-006702-ekf6mja9	388	8	children	child	NNS
cord-006702-ekf6mja9	388	9	who	who	WP
cord-006702-ekf6mja9	388	10	have	have	VBP
cord-006702-ekf6mja9	388	11	had	have	VBN
cord-006702-ekf6mja9	388	12	cardiac	cardiac	JJ
cord-006702-ekf6mja9	388	13	surgery	surgery	NN
cord-006702-ekf6mja9	388	14	have	have	VBP
cord-006702-ekf6mja9	388	15	ongoing	ongoing	JJ
cord-006702-ekf6mja9	388	16	renal	renal	JJ
cord-006702-ekf6mja9	388	17	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	388	18	at	at	IN
cord-006702-ekf6mja9	388	19	5	5	CD
cord-006702-ekf6mja9	388	20	years	year	NNS
cord-006702-ekf6mja9	388	21	.	.	.
cord-006702-ekf6mja9	389	1	The	the	DT
cord-006702-ekf6mja9	389	2	care	care	NN
cord-006702-ekf6mja9	389	3	of	of	IN
cord-006702-ekf6mja9	389	4	this	this	DT
cord-006702-ekf6mja9	389	5	group	group	NN
cord-006702-ekf6mja9	389	6	of	of	IN
cord-006702-ekf6mja9	389	7	children	child	NNS
cord-006702-ekf6mja9	389	8	,	,	,
cord-006702-ekf6mja9	389	9	and	and	CC
cord-006702-ekf6mja9	389	10	identification	identification	NN
cord-006702-ekf6mja9	389	11	of	of	IN
cord-006702-ekf6mja9	389	12	others	other	NNS
cord-006702-ekf6mja9	389	13	at	at	IN
cord-006702-ekf6mja9	389	14	risk	risk	NN
cord-006702-ekf6mja9	389	15	,	,	,
cord-006702-ekf6mja9	389	16	could	could	MD
cord-006702-ekf6mja9	389	17	be	be	VB
cord-006702-ekf6mja9	389	18	improved	improve	VBN
cord-006702-ekf6mja9	389	19	by	by	IN
cord-006702-ekf6mja9	389	20	increasing	increase	VBG
cord-006702-ekf6mja9	389	21	awareness	awareness	NN
cord-006702-ekf6mja9	389	22	.	.	.
cord-006702-ekf6mja9	390	1	A	a	DT
cord-006702-ekf6mja9	390	2	standardised	standardised	JJ
cord-006702-ekf6mja9	390	3	monitoring	monitoring	NN
cord-006702-ekf6mja9	390	4	guideline	guideline	NN
cord-006702-ekf6mja9	390	5	could	could	MD
cord-006702-ekf6mja9	390	6	provide	provide	VB
cord-006702-ekf6mja9	390	7	surveillance	surveillance	NN
cord-006702-ekf6mja9	390	8	over	over	IN
cord-006702-ekf6mja9	390	9	time	time	NN
cord-006702-ekf6mja9	390	10	and	and	CC
cord-006702-ekf6mja9	390	11	enable	enable	VB
cord-006702-ekf6mja9	390	12	collection	collection	NN
cord-006702-ekf6mja9	390	13	of	of	IN
cord-006702-ekf6mja9	390	14	further	further	JJ
cord-006702-ekf6mja9	390	15	data	datum	NNS
cord-006702-ekf6mja9	390	16	.	.	.
cord-006702-ekf6mja9	391	1	FP	FP	NNP
cord-006702-ekf6mja9	391	2	-	-	HYPH
cord-006702-ekf6mja9	391	3	S13	S13	NNP
cord-006702-ekf6mja9	391	4	-	-	HYPH
cord-006702-ekf6mja9	391	5	3	3	NNP
cord-006702-ekf6mja9	391	6	Hemodialysis	Hemodialysis	NNP
cord-006702-ekf6mja9	391	7	in	in	IN
cord-006702-ekf6mja9	391	8	Neonates	Neonates	NNPS
cord-006702-ekf6mja9	391	9	and	and	CC
cord-006702-ekf6mja9	391	10	Infants	Infants	NNPS
cord-006702-ekf6mja9	391	11	:	:	:
cord-006702-ekf6mja9	392	1	A	a	DT
cord-006702-ekf6mja9	392	2	Systematic	Systematic	NNP
cord-006702-ekf6mja9	392	3	Review	review	NN
cord-006702-ekf6mja9	393	1	R.	R.	NNP
cord-006702-ekf6mja9	393	2	Raina	Raina	NNP
cord-006702-ekf6mja9	393	3	(	(	-LRB-
cord-006702-ekf6mja9	393	4	1	1	CD
cord-006702-ekf6mja9	393	5	)	)	-RRB-
cord-006702-ekf6mja9	393	6	,	,	,
cord-006702-ekf6mja9	393	7	M.S.	M.S.	NNP
cord-006702-ekf6mja9	393	8	Ascha	Ascha	NNP
cord-006702-ekf6mja9	393	9	(	(	-LRB-
cord-006702-ekf6mja9	393	10	2	2	CD
cord-006702-ekf6mja9	393	11	)	)	-RRB-
cord-006702-ekf6mja9	393	12	,	,	,
cord-006702-ekf6mja9	393	13	J.	J.	NNP
cord-006702-ekf6mja9	393	14	Darusz	Darusz	NNP
cord-006702-ekf6mja9	393	15	(	(	-LRB-
cord-006702-ekf6mja9	393	16	1	1	CD
cord-006702-ekf6mja9	393	17	)	)	-RRB-
cord-006702-ekf6mja9	393	18	,	,	,
cord-006702-ekf6mja9	393	19	S.K.	S.K.	NNP
cord-006702-ekf6mja9	393	20	Sethi	Sethi	NNP
cord-006702-ekf6mja9	393	21	(	(	-LRB-
cord-006702-ekf6mja9	393	22	3	3	CD
cord-006702-ekf6mja9	393	23	)	)	-RRB-
cord-006702-ekf6mja9	393	24	(	(	-LRB-
cord-006702-ekf6mja9	393	25	1	1	CD
cord-006702-ekf6mja9	393	26	)	)	-RRB-
cord-006702-ekf6mja9	394	1	Akron	Akron	NNP
cord-006702-ekf6mja9	394	2	Children	Children	NNP
cord-006702-ekf6mja9	394	3	's	's	POS
cord-006702-ekf6mja9	394	4	Hospital	Hospital	NNP
cord-006702-ekf6mja9	394	5	,	,	,
cord-006702-ekf6mja9	394	6	Cleveland	Cleveland	NNP
cord-006702-ekf6mja9	394	7	,	,	,
cord-006702-ekf6mja9	394	8	United	United	NNP
cord-006702-ekf6mja9	394	9	States	States	NNP
cord-006702-ekf6mja9	394	10	;	;	:
cord-006702-ekf6mja9	394	11	(	(	-LRB-
cord-006702-ekf6mja9	394	12	2	2	LS
cord-006702-ekf6mja9	394	13	)	)	-RRB-
cord-006702-ekf6mja9	394	14	Case	Case	NNP
cord-006702-ekf6mja9	394	15	Western	Western	NNP
cord-006702-ekf6mja9	394	16	Reserve	Reserve	NNP
cord-006702-ekf6mja9	394	17	University	University	NNP
cord-006702-ekf6mja9	394	18	,	,	,
cord-006702-ekf6mja9	394	19	Cleveland	Cleveland	NNP
cord-006702-ekf6mja9	394	20	,	,	,
cord-006702-ekf6mja9	394	21	United	United	NNP
cord-006702-ekf6mja9	394	22	states	state	VBZ
cord-006702-ekf6mja9	394	23	;	;	,
cord-006702-ekf6mja9	394	24	(	(	-LRB-
cord-006702-ekf6mja9	394	25	3	3	LS
cord-006702-ekf6mja9	394	26	)	)	-RRB-
cord-006702-ekf6mja9	394	27	Medanta	Medanta	NNP
cord-006702-ekf6mja9	394	28	,	,	,
cord-006702-ekf6mja9	394	29	The	the	DT
cord-006702-ekf6mja9	394	30	Medicity	Medicity	NNP
cord-006702-ekf6mja9	394	31	,	,	,
cord-006702-ekf6mja9	394	32	Gurgaon	Gurgaon	NNP
cord-006702-ekf6mja9	394	33	,	,	,
cord-006702-ekf6mja9	394	34	India	India	NNP
cord-006702-ekf6mja9	394	35	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	394	36	:	:	:
cord-006702-ekf6mja9	394	37	BACKGROUND	background	NN
cord-006702-ekf6mja9	394	38	:	:	:
cord-006702-ekf6mja9	395	1	Hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	395	2	(	(	-LRB-
cord-006702-ekf6mja9	395	3	HD	HD	NNP
cord-006702-ekf6mja9	395	4	)	)	-RRB-
cord-006702-ekf6mja9	395	5	in	in	IN
cord-006702-ekf6mja9	395	6	neonates	neonate	NNS
cord-006702-ekf6mja9	395	7	and	and	CC
cord-006702-ekf6mja9	395	8	infants	infant	NNS
cord-006702-ekf6mja9	395	9	can	can	MD
cord-006702-ekf6mja9	395	10	be	be	VB
cord-006702-ekf6mja9	395	11	both	both	RB
cord-006702-ekf6mja9	395	12	difficult	difficult	JJ
cord-006702-ekf6mja9	395	13	to	to	TO
cord-006702-ekf6mja9	395	14	implement	implement	VB
cord-006702-ekf6mja9	395	15	and	and	CC
cord-006702-ekf6mja9	395	16	to	to	TO
cord-006702-ekf6mja9	395	17	maintain	maintain	VB
cord-006702-ekf6mja9	395	18	.	.	.
cord-006702-ekf6mja9	396	1	OBJECTIVES	objectives	NN
cord-006702-ekf6mja9	396	2	:	:	:
cord-006702-ekf6mja9	397	1	To	to	TO
cord-006702-ekf6mja9	397	2	determine	determine	VB
cord-006702-ekf6mja9	397	3	the	the	DT
cord-006702-ekf6mja9	397	4	effectiveness	effectiveness	NN
cord-006702-ekf6mja9	397	5	,	,	,
cord-006702-ekf6mja9	397	6	safety	safety	NN
cord-006702-ekf6mja9	397	7	and	and	CC
cord-006702-ekf6mja9	397	8	feasibility	feasibility	NN
cord-006702-ekf6mja9	397	9	of	of	IN
cord-006702-ekf6mja9	397	10	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	397	11	in	in	IN
cord-006702-ekf6mja9	397	12	infant	infant	NN
cord-006702-ekf6mja9	397	13	population	population	NN
cord-006702-ekf6mja9	397	14	by	by	IN
cord-006702-ekf6mja9	397	15	a	a	DT
cord-006702-ekf6mja9	397	16	systematic	systematic	JJ
cord-006702-ekf6mja9	397	17	review	review	NN
cord-006702-ekf6mja9	397	18	.	.	.
cord-006702-ekf6mja9	398	1	Methods	method	NNS
cord-006702-ekf6mja9	398	2	:	:	:
cord-006702-ekf6mja9	398	3	Design	design	NN
cord-006702-ekf6mja9	398	4	:	:	:
cord-006702-ekf6mja9	398	5	Systematic	Systematic	NNP
cord-006702-ekf6mja9	398	6	Review	Review	NNP
cord-006702-ekf6mja9	398	7	,	,	,
cord-006702-ekf6mja9	398	8	1990	1990	CD
cord-006702-ekf6mja9	398	9	onwards	onwards	RB
cord-006702-ekf6mja9	398	10	studies	study	NNS
cord-006702-ekf6mja9	398	11	.	.	.
cord-006702-ekf6mja9	399	1	PubMed/	PubMed/	NNP
cord-006702-ekf6mja9	399	2	MEDLINE	MEDLINE	NNP
cord-006702-ekf6mja9	399	3	search	search	NN
cord-006702-ekf6mja9	399	4	using	use	VBG
cord-006702-ekf6mja9	399	5	the	the	DT
cord-006702-ekf6mja9	399	6	search	search	NN
cord-006702-ekf6mja9	399	7	term	term	NN
cord-006702-ekf6mja9	399	8	,	,	,
cord-006702-ekf6mja9	399	9	"	"	``
cord-006702-ekf6mja9	399	10	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	399	11	"	"	''
cord-006702-ekf6mja9	399	12	.	.	.
cord-006702-ekf6mja9	400	1	The	the	DT
cord-006702-ekf6mja9	400	2	Medical	Medical	NNP
cord-006702-ekf6mja9	400	3	Subject	Subject	NNP
cord-006702-ekf6mja9	400	4	Heading	head	VBG
cord-006702-ekf6mja9	400	5	(	(	-LRB-
cord-006702-ekf6mja9	400	6	MeSH	MeSH	NNP
cord-006702-ekf6mja9	400	7	)	)	-RRB-
cord-006702-ekf6mja9	400	8	term	term	NN
cord-006702-ekf6mja9	400	9	"	"	``
cord-006702-ekf6mja9	400	10	infant	infant	NN
cord-006702-ekf6mja9	400	11	"	"	''
cord-006702-ekf6mja9	400	12	was	be	VBD
cord-006702-ekf6mja9	400	13	used	use	VBN
cord-006702-ekf6mja9	400	14	to	to	TO
cord-006702-ekf6mja9	400	15	return	return	VB
cord-006702-ekf6mja9	400	16	results	result	NNS
cord-006702-ekf6mja9	400	17	that	that	WDT
cord-006702-ekf6mja9	400	18	pertain	pertain	VBP
cord-006702-ekf6mja9	400	19	to	to	IN
cord-006702-ekf6mja9	400	20	pediatrics	pediatric	NNS
cord-006702-ekf6mja9	400	21	.	.	.
cord-006702-ekf6mja9	401	1	Population	population	NN
cord-006702-ekf6mja9	401	2	:	:	:
cord-006702-ekf6mja9	402	1	Neonatal	neonatal	JJ
cord-006702-ekf6mja9	402	2	patients	patient	NNS
cord-006702-ekf6mja9	402	3	0	0	CD
cord-006702-ekf6mja9	402	4	-	-	SYM
cord-006702-ekf6mja9	402	5	12	12	CD
cord-006702-ekf6mja9	402	6	months	month	NNS
cord-006702-ekf6mja9	402	7	of	of	IN
cord-006702-ekf6mja9	402	8	age	age	NN
cord-006702-ekf6mja9	402	9	treated	treat	VBN
cord-006702-ekf6mja9	402	10	with	with	IN
cord-006702-ekf6mja9	402	11	HD	hd	NN
cord-006702-ekf6mja9	402	12	for	for	IN
cord-006702-ekf6mja9	402	13	indications	indication	NNS
cord-006702-ekf6mja9	402	14	related	relate	VBN
cord-006702-ekf6mja9	402	15	to	to	IN
cord-006702-ekf6mja9	402	16	acute	acute	JJ
cord-006702-ekf6mja9	402	17	kidney	kidney	NN
cord-006702-ekf6mja9	402	18	injury	injury	NN
cord-006702-ekf6mja9	402	19	(	(	-LRB-
cord-006702-ekf6mja9	402	20	AKI	AKI	NNP
cord-006702-ekf6mja9	402	21	)	)	-RRB-
cord-006702-ekf6mja9	402	22	.	.	.
cord-006702-ekf6mja9	403	1	Selection	selection	NN
cord-006702-ekf6mja9	403	2	Criteria	criterion	NNS
cord-006702-ekf6mja9	403	3	:	:	:
cord-006702-ekf6mja9	404	1	Retrospective	retrospective	JJ
cord-006702-ekf6mja9	404	2	reviews	review	NNS
cord-006702-ekf6mja9	404	3	not	not	RB
cord-006702-ekf6mja9	404	4	including	include	VBG
cord-006702-ekf6mja9	404	5	studies	study	NNS
cord-006702-ekf6mja9	404	6	solely	solely	RB
cord-006702-ekf6mja9	404	7	concerned	concern	VBN
cord-006702-ekf6mja9	404	8	with	with	IN
cord-006702-ekf6mja9	404	9	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	404	10	dialysis	dialysis	NN
cord-006702-ekf6mja9	404	11	or	or	CC
cord-006702-ekf6mja9	404	12	continuous	continuous	JJ
cord-006702-ekf6mja9	404	13	renal	renal	JJ
cord-006702-ekf6mja9	404	14	replacement	replacement	NN
cord-006702-ekf6mja9	404	15	therapies	therapy	NNS
cord-006702-ekf6mja9	404	16	,	,	,
cord-006702-ekf6mja9	404	17	studies	study	NNS
cord-006702-ekf6mja9	404	18	of	of	IN
cord-006702-ekf6mja9	404	19	economic	economic	JJ
cord-006702-ekf6mja9	404	20	or	or	CC
cord-006702-ekf6mja9	404	21	ethical	ethical	JJ
cord-006702-ekf6mja9	404	22	issues	issue	NNS
cord-006702-ekf6mja9	404	23	in	in	IN
cord-006702-ekf6mja9	404	24	dialysis	dialysis	NN
cord-006702-ekf6mja9	404	25	care	care	NN
cord-006702-ekf6mja9	404	26	,	,	,
cord-006702-ekf6mja9	404	27	pharmacological	pharmacological	JJ
cord-006702-ekf6mja9	404	28	studies	study	NNS
cord-006702-ekf6mja9	404	29	,	,	,
cord-006702-ekf6mja9	404	30	and	and	CC
cord-006702-ekf6mja9	404	31	articles	article	NNS
cord-006702-ekf6mja9	404	32	not	not	RB
cord-006702-ekf6mja9	404	33	reporting	report	VBG
cord-006702-ekf6mja9	404	34	data	datum	NNS
cord-006702-ekf6mja9	404	35	on	on	IN
cord-006702-ekf6mja9	404	36	a	a	DT
cord-006702-ekf6mja9	404	37	majority	majority	NN
cord-006702-ekf6mja9	404	38	of	of	IN
cord-006702-ekf6mja9	404	39	patient	patient	NN
cord-006702-ekf6mja9	404	40	's	's	POS
cord-006702-ekf6mja9	404	41	ages	age	NNS
cord-006702-ekf6mja9	404	42	.	.	.
cord-006702-ekf6mja9	405	1	Of	of	IN
cord-006702-ekf6mja9	405	2	the	the	DT
cord-006702-ekf6mja9	405	3	1310	1310	CD
cord-006702-ekf6mja9	405	4	returned	return	VBD
cord-006702-ekf6mja9	405	5	results	result	NNS
cord-006702-ekf6mja9	405	6	,	,	,
cord-006702-ekf6mja9	405	7	only	only	RB
cord-006702-ekf6mja9	405	8	9	9	CD
cord-006702-ekf6mja9	405	9	studies	study	NNS
cord-006702-ekf6mja9	405	10	were	be	VBD
cord-006702-ekf6mja9	405	11	eligible	eligible	JJ
cord-006702-ekf6mja9	405	12	for	for	IN
cord-006702-ekf6mja9	405	13	review	review	NN
cord-006702-ekf6mja9	405	14	.	.	.
cord-006702-ekf6mja9	406	1	Results	result	NNS
cord-006702-ekf6mja9	406	2	:	:	:
cord-006702-ekf6mja9	407	1	Nine	nine	CD
cord-006702-ekf6mja9	407	2	studies	study	NNS
cord-006702-ekf6mja9	407	3	reported	report	VBD
cord-006702-ekf6mja9	407	4	HD	HD	NNP
cord-006702-ekf6mja9	407	5	use	use	NN
cord-006702-ekf6mja9	407	6	in	in	IN
cord-006702-ekf6mja9	407	7	a	a	DT
cord-006702-ekf6mja9	407	8	total	total	NN
cord-006702-ekf6mja9	407	9	of	of	IN
cord-006702-ekf6mja9	407	10	104	104	CD
cord-006702-ekf6mja9	407	11	neonatal	neonatal	JJ
cord-006702-ekf6mja9	407	12	patients	patient	NNS
cord-006702-ekf6mja9	407	13	.	.	.
cord-006702-ekf6mja9	408	1	A	a	DT
cord-006702-ekf6mja9	408	2	pooled	pooled	JJ
cord-006702-ekf6mja9	408	3	mean	mean	JJ
cord-006702-ekf6mja9	408	4	age	age	NN
cord-006702-ekf6mja9	408	5	of	of	IN
cord-006702-ekf6mja9	408	6	3.1	3.1	CD
cord-006702-ekf6mja9	408	7	months	month	NNS
cord-006702-ekf6mja9	408	8	(	(	-LRB-
cord-006702-ekf6mja9	408	9	range	range	NN
cord-006702-ekf6mja9	408	10	:	:	:
cord-006702-ekf6mja9	408	11	2	2	CD
cord-006702-ekf6mja9	408	12	days	day	NNS
cord-006702-ekf6mja9	408	13	to	to	IN
cord-006702-ekf6mja9	408	14	12	12	CD
cord-006702-ekf6mja9	408	15	months	month	NNS
cord-006702-ekf6mja9	408	16	)	)	-RRB-
cord-006702-ekf6mja9	408	17	was	be	VBD
cord-006702-ekf6mja9	408	18	calculated	calculate	VBN
cord-006702-ekf6mja9	408	19	.	.	.
cord-006702-ekf6mja9	409	1	Among	among	IN
cord-006702-ekf6mja9	409	2	all	all	DT
cord-006702-ekf6mja9	409	3	subjects	subject	NNS
cord-006702-ekf6mja9	409	4	,	,	,
cord-006702-ekf6mja9	409	5	there	there	EX
cord-006702-ekf6mja9	409	6	was	be	VBD
cord-006702-ekf6mja9	409	7	38	38	CD
cord-006702-ekf6mja9	409	8	%	%	NN
cord-006702-ekf6mja9	409	9	mortality	mortality	NN
cord-006702-ekf6mja9	409	10	,	,	,
cord-006702-ekf6mja9	409	11	and	and	CC
cord-006702-ekf6mja9	409	12	a	a	DT
cord-006702-ekf6mja9	409	13	33	33	CD
cord-006702-ekf6mja9	409	14	%	%	NN
cord-006702-ekf6mja9	409	15	rate	rate	NN
cord-006702-ekf6mja9	409	16	of	of	IN
cord-006702-ekf6mja9	409	17	transplantation	transplantation	NN
cord-006702-ekf6mja9	409	18	.	.	.
cord-006702-ekf6mja9	410	1	42	42	CD
cord-006702-ekf6mja9	410	2	%	%	NN
cord-006702-ekf6mja9	410	3	of	of	IN
cord-006702-ekf6mja9	410	4	patients	patient	NNS
cord-006702-ekf6mja9	410	5	presented	present	VBN
cord-006702-ekf6mja9	410	6	with	with	IN
cord-006702-ekf6mja9	410	7	metabolic	metabolic	JJ
cord-006702-ekf6mja9	410	8	issues	issue	NNS
cord-006702-ekf6mja9	410	9	,	,	,
cord-006702-ekf6mja9	410	10	32	32	CD
cord-006702-ekf6mja9	410	11	%	%	NN
cord-006702-ekf6mja9	410	12	with	with	IN
cord-006702-ekf6mja9	410	13	acute	acute	JJ
cord-006702-ekf6mja9	410	14	kidney	kidney	NN
cord-006702-ekf6mja9	410	15	injury	injury	NN
cord-006702-ekf6mja9	410	16	,	,	,
cord-006702-ekf6mja9	410	17	and	and	CC
cord-006702-ekf6mja9	410	18	17	17	CD
cord-006702-ekf6mja9	410	19	%	%	NN
cord-006702-ekf6mja9	410	20	with	with	IN
cord-006702-ekf6mja9	410	21	renal	renal	JJ
cord-006702-ekf6mja9	410	22	dysplasias	dysplasia	NNS
cord-006702-ekf6mja9	410	23	.	.	.
cord-006702-ekf6mja9	411	1	HD	HD	NNP
cord-006702-ekf6mja9	411	2	prescription	prescription	NN
cord-006702-ekf6mja9	411	3	Vascular	Vascular	NNP
cord-006702-ekf6mja9	411	4	access	access	NN
cord-006702-ekf6mja9	411	5	was	be	VBD
cord-006702-ekf6mja9	411	6	primary	primary	JJ
cord-006702-ekf6mja9	411	7	achieved	achieve	VBN
cord-006702-ekf6mja9	411	8	via	via	IN
cord-006702-ekf6mja9	411	9	the	the	DT
cord-006702-ekf6mja9	411	10	internal	internal	JJ
cord-006702-ekf6mja9	411	11	jugular	jugular	NN
cord-006702-ekf6mja9	411	12	vein	vein	NN
cord-006702-ekf6mja9	411	13	followed	follow	VBN
cord-006702-ekf6mja9	411	14	by	by	IN
cord-006702-ekf6mja9	411	15	the	the	DT
cord-006702-ekf6mja9	411	16	subclavian	subclavian	NNP
cord-006702-ekf6mja9	411	17	.	.	.
cord-006702-ekf6mja9	412	1	The	the	DT
cord-006702-ekf6mja9	412	2	most	most	RBS
cord-006702-ekf6mja9	412	3	common	common	JJ
cord-006702-ekf6mja9	412	4	complications	complication	NNS
cord-006702-ekf6mja9	412	5	were	be	VBD
cord-006702-ekf6mja9	412	6	mechanical	mechanical	JJ
cord-006702-ekf6mja9	412	7	catheter	catheter	NN
cord-006702-ekf6mja9	412	8	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	412	9	and	and	CC
cord-006702-ekf6mja9	412	10	hemodynamic	hemodynamic	JJ
cord-006702-ekf6mja9	412	11	issues	issue	NNS
cord-006702-ekf6mja9	412	12	such	such	JJ
cord-006702-ekf6mja9	412	13	as	as	IN
cord-006702-ekf6mja9	412	14	hypotension	hypotension	NN
cord-006702-ekf6mja9	412	15	and	and	CC
cord-006702-ekf6mja9	412	16	anemia	anemia	NN
cord-006702-ekf6mja9	412	17	Patient	Patient	NNP
cord-006702-ekf6mja9	412	18	Outcomes	Outcomes	NNP
cord-006702-ekf6mja9	412	19	39	39	CD
cord-006702-ekf6mja9	412	20	of	of	IN
cord-006702-ekf6mja9	412	21	104	104	CD
cord-006702-ekf6mja9	412	22	total	total	JJ
cord-006702-ekf6mja9	412	23	patients	patient	NNS
cord-006702-ekf6mja9	412	24	died	die	VBD
cord-006702-ekf6mja9	412	25	,	,	,
cord-006702-ekf6mja9	412	26	resulting	result	VBG
cord-006702-ekf6mja9	412	27	in	in	IN
cord-006702-ekf6mja9	412	28	a	a	DT
cord-006702-ekf6mja9	412	29	mortality	mortality	NN
cord-006702-ekf6mja9	412	30	rate	rate	NN
cord-006702-ekf6mja9	412	31	of	of	IN
cord-006702-ekf6mja9	412	32	37.5	37.5	CD
cord-006702-ekf6mja9	412	33	%	%	NN
cord-006702-ekf6mja9	412	34	.	.	.
cord-006702-ekf6mja9	413	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	413	2	:	:	:
cord-006702-ekf6mja9	414	1	Treating	treat	VBG
cord-006702-ekf6mja9	414	2	neonatal	neonatal	JJ
cord-006702-ekf6mja9	414	3	and	and	CC
cord-006702-ekf6mja9	414	4	infant	infant	NN
cord-006702-ekf6mja9	414	5	patients	patient	NNS
cord-006702-ekf6mja9	414	6	with	with	IN
cord-006702-ekf6mja9	414	7	HD	HD	NNP
cord-006702-ekf6mja9	414	8	may	may	MD
cord-006702-ekf6mja9	414	9	pose	pose	VB
cord-006702-ekf6mja9	414	10	many	many	JJ
cord-006702-ekf6mja9	414	11	challenges	challenge	NNS
cord-006702-ekf6mja9	414	12	,	,	,
cord-006702-ekf6mja9	414	13	but	but	CC
cord-006702-ekf6mja9	414	14	it	-PRON-	PRP
cord-006702-ekf6mja9	414	15	is	be	VBZ
cord-006702-ekf6mja9	414	16	a	a	DT
cord-006702-ekf6mja9	414	17	feasible	feasible	JJ
cord-006702-ekf6mja9	414	18	treatment	treatment	NN
cord-006702-ekf6mja9	414	19	modality	modality	NN
cord-006702-ekf6mja9	414	20	and	and	CC
cord-006702-ekf6mja9	414	21	when	when	WRB
cord-006702-ekf6mja9	414	22	executed	execute	VBN
cord-006702-ekf6mja9	414	23	properly	properly	RB
cord-006702-ekf6mja9	414	24	can	can	MD
cord-006702-ekf6mja9	414	25	quickly	quickly	RB
cord-006702-ekf6mja9	414	26	reverse	reverse	VB
cord-006702-ekf6mja9	414	27	pathology	pathology	NN
cord-006702-ekf6mja9	414	28	.	.	.
cord-006702-ekf6mja9	415	1	Such	such	JJ
cord-006702-ekf6mja9	415	2	techniques	technique	NNS
cord-006702-ekf6mja9	415	3	such	such	JJ
cord-006702-ekf6mja9	415	4	as	as	IN
cord-006702-ekf6mja9	415	5	blood	blood	NN
cord-006702-ekf6mja9	415	6	priming	priming	NN
cord-006702-ekf6mja9	415	7	,	,	,
cord-006702-ekf6mja9	415	8	minimizing	minimize	VBG
cord-006702-ekf6mja9	415	9	extracorporeal	extracorporeal	JJ
cord-006702-ekf6mja9	415	10	volume	volume	NN
cord-006702-ekf6mja9	415	11	,	,	,
cord-006702-ekf6mja9	415	12	and	and	CC
cord-006702-ekf6mja9	415	13	increased	increase	VBN
cord-006702-ekf6mja9	415	14	maintenance	maintenance	NN
cord-006702-ekf6mja9	415	15	of	of	IN
cord-006702-ekf6mja9	415	16	vascular	vascular	JJ
cord-006702-ekf6mja9	415	17	access	access	NN
cord-006702-ekf6mja9	415	18	can	can	MD
cord-006702-ekf6mja9	415	19	all	all	DT
cord-006702-ekf6mja9	415	20	potentially	potentially	RB
cord-006702-ekf6mja9	415	21	improve	improve	VB
cord-006702-ekf6mja9	415	22	patient	patient	JJ
cord-006702-ekf6mja9	415	23	outcomes	outcome	NNS
cord-006702-ekf6mja9	415	24	.	.	.
cord-006702-ekf6mja9	416	1	S14	S14	NNP
cord-006702-ekf6mja9	416	2	-Therapies	-therapie	VBZ
cord-006702-ekf6mja9	416	3	for	for	IN
cord-006702-ekf6mja9	416	4	difficult	difficult	JJ
cord-006702-ekf6mja9	417	1	the	the	DT
cord-006702-ekf6mja9	417	2	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	417	3	syndrome	syndrome	NN
cord-006702-ekf6mja9	417	4	FP	FP	NNP
cord-006702-ekf6mja9	417	5	-	-	HYPH
cord-006702-ekf6mja9	417	6	S14	S14	NNP
cord-006702-ekf6mja9	417	7	-	-	HYPH
cord-006702-ekf6mja9	417	8	1	1	CD
cord-006702-ekf6mja9	417	9	Hyporesponsive	Hyporesponsive	NNP
cord-006702-ekf6mja9	417	10	T	t	NN
cord-006702-ekf6mja9	417	11	-	-	HYPH
cord-006702-ekf6mja9	417	12	cell	cell	NN
cord-006702-ekf6mja9	417	13	activation	activation	NN
cord-006702-ekf6mja9	417	14	subsets	subset	NNS
cord-006702-ekf6mja9	417	15	predict	predict	VBP
cord-006702-ekf6mja9	417	16	favorable	favorable	JJ
cord-006702-ekf6mja9	417	17	rituximab	rituximab	JJ
cord-006702-ekf6mja9	417	18	response	response	NN
cord-006702-ekf6mja9	417	19	in	in	IN
cord-006702-ekf6mja9	417	20	patients	patient	NNS
cord-006702-ekf6mja9	417	21	with	with	IN
cord-006702-ekf6mja9	417	22	focal	focal	JJ
cord-006702-ekf6mja9	417	23	segmental	segmental	JJ
cord-006702-ekf6mja9	417	24	glomerulosclerosis	glomerulosclerosis	NN
cord-006702-ekf6mja9	418	1	(	(	-LRB-
cord-006702-ekf6mja9	418	2	FSGS	FSGS	NNP
cord-006702-ekf6mja9	418	3	)	)	-RRB-
cord-006702-ekf6mja9	418	4	C.Y.	C.Y.	NNP
cord-006702-ekf6mja9	418	5	Chan	Chan	NNP
cord-006702-ekf6mja9	418	6	(	(	-LRB-
cord-006702-ekf6mja9	418	7	1	1	CD
cord-006702-ekf6mja9	418	8	)	)	-RRB-
cord-006702-ekf6mja9	418	9	,	,	,
cord-006702-ekf6mja9	418	10	I.D.	I.D.	NNP
cord-006702-ekf6mja9	418	11	Liu	Liu	NNP
cord-006702-ekf6mja9	418	12	(	(	-LRB-
cord-006702-ekf6mja9	418	13	1	1	CD
cord-006702-ekf6mja9	418	14	)	)	-RRB-
cord-006702-ekf6mja9	418	15	,	,	.
cord-006702-ekf6mja9	419	1	L.P.	L.P.	NNP
cord-006702-ekf6mja9	419	2	Resontoc	Resontoc	NNP
cord-006702-ekf6mja9	419	3	(	(	-LRB-
cord-006702-ekf6mja9	419	4	1	1	CD
cord-006702-ekf6mja9	419	5	)	)	-RRB-
cord-006702-ekf6mja9	419	6	,	,	,
cord-006702-ekf6mja9	419	7	K	K	NNP
cord-006702-ekf6mja9	419	8	-	-	HYPH
cord-006702-ekf6mja9	419	9	H.	H.	NNP
cord-006702-ekf6mja9	419	10	Ng	Ng	NNP
cord-006702-ekf6mja9	419	11	(	(	-LRB-
cord-006702-ekf6mja9	419	12	1	1	CD
cord-006702-ekf6mja9	419	13	)	)	-RRB-
cord-006702-ekf6mja9	419	14	,	,	,
cord-006702-ekf6mja9	419	15	Y	Y	NNP
cord-006702-ekf6mja9	419	16	-	-	HYPH
cord-006702-ekf6mja9	419	17	H.	H.	NNP
cord-006702-ekf6mja9	419	18	Chan	Chan	NNP
cord-006702-ekf6mja9	419	19	(	(	-LRB-
cord-006702-ekf6mja9	419	20	1	1	CD
cord-006702-ekf6mja9	419	21	)	)	-RRB-
cord-006702-ekf6mja9	419	22	,	,	,
cord-006702-ekf6mja9	419	23	K	K	NNP
cord-006702-ekf6mja9	419	24	-	-	HYPH
cord-006702-ekf6mja9	419	25	P.	P.	NNP
cord-006702-ekf6mja9	419	26	Lam	Lam	NNP
cord-006702-ekf6mja9	419	27	(	(	-LRB-
cord-006702-ekf6mja9	419	28	2	2	CD
cord-006702-ekf6mja9	419	29	)	)	-RRB-
cord-006702-ekf6mja9	419	30	,	,	,
cord-006702-ekf6mja9	419	31	W	W	NNP
cord-006702-ekf6mja9	419	32	-	-	HYPH
cord-006702-ekf6mja9	419	33	S.	S.	NNP
cord-006702-ekf6mja9	419	34	Yeo	Yeo	NNP
cord-006702-ekf6mja9	419	35	(	(	-LRB-
cord-006702-ekf6mja9	419	36	1	1	CD
cord-006702-ekf6mja9	419	37	)	)	-RRB-
cord-006702-ekf6mja9	419	38	,	,	,
cord-006702-ekf6mja9	419	39	H	H	NNP
cord-006702-ekf6mja9	419	40	-	-	HYPH
cord-006702-ekf6mja9	419	41	K.	K.	NNP
cord-006702-ekf6mja9	419	42	Yap	Yap	NNP
cord-006702-ekf6mja9	419	43	(	(	-LRB-
cord-006702-ekf6mja9	419	44	1	1	CD
cord-006702-ekf6mja9	419	45	)	)	-RRB-
cord-006702-ekf6mja9	419	46	(	(	-LRB-
cord-006702-ekf6mja9	419	47	1	1	LS
cord-006702-ekf6mja9	419	48	)	)	-RRB-
cord-006702-ekf6mja9	419	49	National	National	NNP
cord-006702-ekf6mja9	419	50	University	University	NNP
cord-006702-ekf6mja9	419	51	of	of	IN
cord-006702-ekf6mja9	419	52	Singapore	Singapore	NNP
cord-006702-ekf6mja9	419	53	,	,	,
cord-006702-ekf6mja9	419	54	Singapore	Singapore	NNP
cord-006702-ekf6mja9	419	55	,	,	,
cord-006702-ekf6mja9	419	56	Singapore	Singapore	NNP
cord-006702-ekf6mja9	419	57	;	;	:
cord-006702-ekf6mja9	419	58	(	(	-LRB-
cord-006702-ekf6mja9	419	59	2	2	LS
cord-006702-ekf6mja9	419	60	)	)	-RRB-
cord-006702-ekf6mja9	419	61	Agency	Agency	NNP
cord-006702-ekf6mja9	419	62	for	for	IN
cord-006702-ekf6mja9	419	63	Science	Science	NNP
cord-006702-ekf6mja9	419	64	,	,	,
cord-006702-ekf6mja9	419	65	Technology	Technology	NNP
cord-006702-ekf6mja9	419	66	and	and	CC
cord-006702-ekf6mja9	419	67	Research	Research	NNP
cord-006702-ekf6mja9	419	68	(	(	-LRB-
cord-006702-ekf6mja9	419	69	A*star	A*star	NNP
cord-006702-ekf6mja9	419	70	)	)	-RRB-
cord-006702-ekf6mja9	419	71	,	,	,
cord-006702-ekf6mja9	419	72	Singapore	Singapore	NNP
cord-006702-ekf6mja9	419	73	,	,	,
cord-006702-ekf6mja9	419	74	Singapore	Singapore	NNP
cord-006702-ekf6mja9	419	75	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	419	76	:	:	:
cord-006702-ekf6mja9	419	77	The	the	DT
cord-006702-ekf6mja9	419	78	use	use	NN
cord-006702-ekf6mja9	419	79	of	of	IN
cord-006702-ekf6mja9	419	80	rituximab	rituximab	NN
cord-006702-ekf6mja9	419	81	in	in	IN
cord-006702-ekf6mja9	419	82	refractory	refractory	JJ
cord-006702-ekf6mja9	419	83	idiopathic	idiopathic	JJ
cord-006702-ekf6mja9	419	84	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	419	85	syndrome	syndrome	NN
cord-006702-ekf6mja9	419	86	especially	especially	RB
cord-006702-ekf6mja9	419	87	FSGS	FSGS	NNP
cord-006702-ekf6mja9	419	88	has	have	VBZ
cord-006702-ekf6mja9	419	89	met	meet	VBN
cord-006702-ekf6mja9	419	90	with	with	IN
cord-006702-ekf6mja9	419	91	variable	variable	JJ
cord-006702-ekf6mja9	419	92	success	success	NN
cord-006702-ekf6mja9	419	93	.	.	.
cord-006702-ekf6mja9	420	1	As	as	IN
cord-006702-ekf6mja9	420	2	B	b	NN
cord-006702-ekf6mja9	420	3	-	-	HYPH
cord-006702-ekf6mja9	420	4	cell	cell	NN
cord-006702-ekf6mja9	420	5	depletion	depletion	NN
cord-006702-ekf6mja9	420	6	can	can	MD
cord-006702-ekf6mja9	420	7	impact	impact	VB
cord-006702-ekf6mja9	420	8	T	t	NN
cord-006702-ekf6mja9	420	9	-	-	HYPH
cord-006702-ekf6mja9	420	10	cell	cell	NN
cord-006702-ekf6mja9	420	11	function	function	NN
cord-006702-ekf6mja9	420	12	,	,	,
cord-006702-ekf6mja9	420	13	this	this	DT
cord-006702-ekf6mja9	420	14	study	study	NN
cord-006702-ekf6mja9	420	15	aimed	aim	VBD
cord-006702-ekf6mja9	420	16	to	to	TO
cord-006702-ekf6mja9	420	17	characterize	characterize	VB
cord-006702-ekf6mja9	420	18	T	t	NN
cord-006702-ekf6mja9	420	19	-	-	HYPH
cord-006702-ekf6mja9	420	20	cell	cell	NN
cord-006702-ekf6mja9	420	21	subsets	subset	NNS
cord-006702-ekf6mja9	420	22	in	in	IN
cord-006702-ekf6mja9	420	23	FSGS	FSGS	NNP
cord-006702-ekf6mja9	420	24	patients	patient	NNS
cord-006702-ekf6mja9	420	25	in	in	IN
cord-006702-ekf6mja9	420	26	order	order	NN
cord-006702-ekf6mja9	420	27	to	to	TO
cord-006702-ekf6mja9	420	28	identify	identify	VB
cord-006702-ekf6mja9	420	29	an	an	DT
cord-006702-ekf6mja9	420	30	immunological	immunological	JJ
cord-006702-ekf6mja9	420	31	signature	signature	NN
cord-006702-ekf6mja9	420	32	predictive	predictive	NN
cord-006702-ekf6mja9	420	33	of	of	IN
cord-006702-ekf6mja9	420	34	favorable	favorable	JJ
cord-006702-ekf6mja9	420	35	response	response	NN
cord-006702-ekf6mja9	420	36	to	to	IN
cord-006702-ekf6mja9	420	37	rituximab	rituximab	NN
cord-006702-ekf6mja9	420	38	therapy	therapy	NN
cord-006702-ekf6mja9	420	39	.	.	.
cord-006702-ekf6mja9	421	1	Methods	method	NNS
cord-006702-ekf6mja9	421	2	:	:	:
cord-006702-ekf6mja9	421	3	22	22	CD
cord-006702-ekf6mja9	421	4	consecutive	consecutive	JJ
cord-006702-ekf6mja9	421	5	FSGS	FSGS	NNP
cord-006702-ekf6mja9	421	6	patients	patient	NNS
cord-006702-ekf6mja9	421	7	(	(	-LRB-
cord-006702-ekf6mja9	421	8	median	median	JJ
cord-006702-ekf6mja9	421	9	age	age	NN
cord-006702-ekf6mja9	421	10	14.4	14.4	CD
cord-006702-ekf6mja9	421	11	years	year	NNS
cord-006702-ekf6mja9	421	12	,	,	,
cord-006702-ekf6mja9	421	13	range	range	VBP
cord-006702-ekf6mja9	421	14	6.2	6.2	CD
cord-006702-ekf6mja9	421	15	-	-	HYPH
cord-006702-ekf6mja9	421	16	25.0	25.0	CD
cord-006702-ekf6mja9	421	17	years	year	NNS
cord-006702-ekf6mja9	421	18	)	)	-RRB-
cord-006702-ekf6mja9	421	19	who	who	WP
cord-006702-ekf6mja9	421	20	received	receive	VBD
cord-006702-ekf6mja9	421	21	rituximab	rituximab	NN
cord-006702-ekf6mja9	421	22	as	as	IN
cord-006702-ekf6mja9	421	23	third	third	JJ
cord-006702-ekf6mja9	421	24	line	line	NN
cord-006702-ekf6mja9	421	25	therapy	therapy	NN
cord-006702-ekf6mja9	421	26	following	follow	VBG
cord-006702-ekf6mja9	421	27	steroids	steroid	NNS
cord-006702-ekf6mja9	421	28	and	and	CC
cord-006702-ekf6mja9	421	29	calcineurin	calcineurin	NN
cord-006702-ekf6mja9	421	30	inhibitors	inhibitor	NNS
cord-006702-ekf6mja9	421	31	(	(	-LRB-
cord-006702-ekf6mja9	421	32	CNI	CNI	NNP
cord-006702-ekf6mja9	421	33	)	)	-RRB-
cord-006702-ekf6mja9	421	34	,	,	,
cord-006702-ekf6mja9	421	35	were	be	VBD
cord-006702-ekf6mja9	421	36	included	include	VBN
cord-006702-ekf6mja9	421	37	in	in	IN
cord-006702-ekf6mja9	421	38	the	the	DT
cord-006702-ekf6mja9	421	39	study	study	NN
cord-006702-ekf6mja9	421	40	.	.	.
cord-006702-ekf6mja9	422	1	Clinical	clinical	JJ
cord-006702-ekf6mja9	422	2	parameters	parameter	NNS
cord-006702-ekf6mja9	422	3	including	include	VBG
cord-006702-ekf6mja9	422	4	urinary	urinary	JJ
cord-006702-ekf6mja9	422	5	protein	protein	NN
cord-006702-ekf6mja9	422	6	excretion	excretion	NN
cord-006702-ekf6mja9	422	7	and	and	CC
cord-006702-ekf6mja9	422	8	serum	serum	NN
cord-006702-ekf6mja9	422	9	albumin	albumin	NN
cord-006702-ekf6mja9	422	10	,	,	,
cord-006702-ekf6mja9	422	11	as	as	RB
cord-006702-ekf6mja9	422	12	well	well	RB
cord-006702-ekf6mja9	422	13	as	as	IN
cord-006702-ekf6mja9	422	14	immunological	immunological	JJ
cord-006702-ekf6mja9	422	15	subset	subset	JJ
cord-006702-ekf6mja9	422	16	monitoring	monitoring	NN
cord-006702-ekf6mja9	422	17	were	be	VBD
cord-006702-ekf6mja9	422	18	performed	perform	VBN
cord-006702-ekf6mja9	422	19	at	at	IN
cord-006702-ekf6mja9	422	20	baseline	baseline	NN
cord-006702-ekf6mja9	422	21	,	,	,
cord-006702-ekf6mja9	422	22	14-days	14-days	CD
cord-006702-ekf6mja9	422	23	,	,	,
cord-006702-ekf6mja9	422	24	1-month	1-month	CD
cord-006702-ekf6mja9	422	25	,	,	,
cord-006702-ekf6mja9	422	26	and	and	CC
cord-006702-ekf6mja9	422	27	subsequently	subsequently	RB
cord-006702-ekf6mja9	422	28	3-monthly	3-monthly	CD
cord-006702-ekf6mja9	422	29	until	until	IN
cord-006702-ekf6mja9	422	30	relapse	relapse	NN
cord-006702-ekf6mja9	422	31	.	.	.
cord-006702-ekf6mja9	423	1	Baseline	baseline	JJ
cord-006702-ekf6mja9	423	2	immunological	immunological	JJ
cord-006702-ekf6mja9	423	3	subsets	subset	NNS
cord-006702-ekf6mja9	423	4	were	be	VBD
cord-006702-ekf6mja9	423	5	compared	compare	VBN
cord-006702-ekf6mja9	423	6	between	between	IN
cord-006702-ekf6mja9	423	7	rituximab	rituximab	JJ
cord-006702-ekf6mja9	423	8	responders	responder	NNS
cord-006702-ekf6mja9	423	9	and	and	CC
cord-006702-ekf6mja9	423	10	non	non	NNS
cord-006702-ekf6mja9	423	11	-	-	NNS
cord-006702-ekf6mja9	423	12	responders	responder	NNS
cord-006702-ekf6mja9	423	13	,	,	,
cord-006702-ekf6mja9	423	14	as	as	RB
cord-006702-ekf6mja9	423	15	well	well	RB
cord-006702-ekf6mja9	423	16	as	as	IN
cord-006702-ekf6mja9	423	17	22	22	CD
cord-006702-ekf6mja9	423	18	patients	patient	NNS
cord-006702-ekf6mja9	423	19	with	with	IN
cord-006702-ekf6mja9	423	20	minimal	minimal	JJ
cord-006702-ekf6mja9	423	21	change	change	NN
cord-006702-ekf6mja9	423	22	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	423	23	syndrome	syndrome	NN
cord-006702-ekf6mja9	423	24	(	(	-LRB-
cord-006702-ekf6mja9	423	25	MCNS	MCNS	NNP
cord-006702-ekf6mja9	423	26	)	)	-RRB-
cord-006702-ekf6mja9	423	27	in	in	IN
cord-006702-ekf6mja9	423	28	relapse	relapse	NN
cord-006702-ekf6mja9	423	29	and	and	CC
cord-006702-ekf6mja9	423	30	30	30	CD
cord-006702-ekf6mja9	423	31	healthy	healthy	JJ
cord-006702-ekf6mja9	423	32	controls	control	NNS
cord-006702-ekf6mja9	423	33	,	,	,
cord-006702-ekf6mja9	423	34	using	use	VBG
cord-006702-ekf6mja9	423	35	Mann	Mann	NNP
cord-006702-ekf6mja9	423	36	-	-	HYPH
cord-006702-ekf6mja9	423	37	Whitney	Whitney	NNP
cord-006702-ekf6mja9	423	38	U	U	NNP
cord-006702-ekf6mja9	423	39	Test	Test	NNP
cord-006702-ekf6mja9	423	40	.	.	.
cord-006702-ekf6mja9	424	1	Paired	pair	VBN
cord-006702-ekf6mja9	424	2	comparison	comparison	NN
cord-006702-ekf6mja9	424	3	was	be	VBD
cord-006702-ekf6mja9	424	4	done	do	VBN
cord-006702-ekf6mja9	424	5	using	use	VBG
cord-006702-ekf6mja9	424	6	Wilcoxon	Wilcoxon	NNP
cord-006702-ekf6mja9	424	7	signed	sign	VBN
cord-006702-ekf6mja9	424	8	rank	rank	NN
cord-006702-ekf6mja9	424	9	test	test	NN
cord-006702-ekf6mja9	424	10	.	.	.
cord-006702-ekf6mja9	425	1	Results	result	NNS
cord-006702-ekf6mja9	425	2	:	:	:
cord-006702-ekf6mja9	426	1	12	12	CD
cord-006702-ekf6mja9	426	2	of	of	IN
cord-006702-ekf6mja9	426	3	22	22	CD
cord-006702-ekf6mja9	426	4	patients	patient	NNS
cord-006702-ekf6mja9	426	5	(	(	-LRB-
cord-006702-ekf6mja9	426	6	54.5	54.5	CD
cord-006702-ekf6mja9	426	7	%	%	NN
cord-006702-ekf6mja9	426	8	)	)	-RRB-
cord-006702-ekf6mja9	426	9	responded	respond	VBD
cord-006702-ekf6mja9	426	10	to	to	IN
cord-006702-ekf6mja9	426	11	rituximab	rituximab	NN
cord-006702-ekf6mja9	426	12	therapy	therapy	NN
cord-006702-ekf6mja9	426	13	,	,	,
cord-006702-ekf6mja9	426	14	defined	define	VBN
cord-006702-ekf6mja9	426	15	as	as	IN
cord-006702-ekf6mja9	426	16	resolution	resolution	NN
cord-006702-ekf6mja9	426	17	of	of	IN
cord-006702-ekf6mja9	426	18	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	426	19	and	and	CC
cord-006702-ekf6mja9	426	20	ability	ability	NN
cord-006702-ekf6mja9	426	21	to	to	TO
cord-006702-ekf6mja9	426	22	wean	wean	VB
cord-006702-ekf6mja9	426	23	off	off	RP
cord-006702-ekf6mja9	426	24	steroids	steroid	NNS
cord-006702-ekf6mja9	426	25	and	and	CC
cord-006702-ekf6mja9	426	26	CNI	CNI	NNP
cord-006702-ekf6mja9	426	27	at	at	IN
cord-006702-ekf6mja9	426	28	3	3	CD
cord-006702-ekf6mja9	426	29	months	month	NNS
cord-006702-ekf6mja9	426	30	following	follow	VBG
cord-006702-ekf6mja9	426	31	rituximab	rituximab	JJ
cord-006702-ekf6mja9	426	32	treatment	treatment	NN
cord-006702-ekf6mja9	426	33	.	.	.
cord-006702-ekf6mja9	427	1	Mitogen	Mitogen	NNP
cord-006702-ekf6mja9	427	2	-	-	HYPH
cord-006702-ekf6mja9	427	3	stimulated	stimulate	VBN
cord-006702-ekf6mja9	427	4	T	t	NN
cord-006702-ekf6mja9	427	5	-	-	HYPH
cord-006702-ekf6mja9	427	6	cell	cell	NN
cord-006702-ekf6mja9	427	7	activation	activation	NN
cord-006702-ekf6mja9	427	8	subset	subset	VBN
cord-006702-ekf6mja9	427	9	expressions	expression	NNS
cord-006702-ekf6mja9	427	10	are	be	VBP
cord-006702-ekf6mja9	427	11	shown	show	VBN
cord-006702-ekf6mja9	427	12	in	in	IN
cord-006702-ekf6mja9	427	13	the	the	DT
cord-006702-ekf6mja9	427	14	Table	table	NN
cord-006702-ekf6mja9	427	15	1	1	CD
cord-006702-ekf6mja9	427	16	below	below	RB
cord-006702-ekf6mja9	427	17	.	.	.
cord-006702-ekf6mja9	428	1	Mitogen	Mitogen	NNP
cord-006702-ekf6mja9	428	2	-	-	HYPH
cord-006702-ekf6mja9	428	3	stimulated	stimulate	VBN
cord-006702-ekf6mja9	429	1	CD154	CD154	NNP
cord-006702-ekf6mja9	430	1	+	+	CC
cord-006702-ekf6mja9	431	1	CD4	CD4	NNP
cord-006702-ekf6mja9	431	2	+	+	CC
cord-006702-ekf6mja9	431	3	CD3	CD3	NNP
cord-006702-ekf6mja9	432	1	+	+	CC
cord-006702-ekf6mja9	432	2	expressions	expression	NNS
cord-006702-ekf6mja9	432	3	before	before	IN
cord-006702-ekf6mja9	432	4	rituximab	rituximab	NN
cord-006702-ekf6mja9	432	5	were	be	VBD
cord-006702-ekf6mja9	432	6	significantly	significantly	RB
cord-006702-ekf6mja9	432	7	lower	low	JJR
cord-006702-ekf6mja9	432	8	in	in	IN
cord-006702-ekf6mja9	432	9	FSGS	FSGS	NNP
cord-006702-ekf6mja9	432	10	responders	responder	NNS
cord-006702-ekf6mja9	432	11	compared	compare	VBN
cord-006702-ekf6mja9	432	12	to	to	IN
cord-006702-ekf6mja9	432	13	non	non	JJ
cord-006702-ekf6mja9	432	14	-	-	NNS
cord-006702-ekf6mja9	432	15	responders	responder	NNS
cord-006702-ekf6mja9	432	16	and	and	CC
cord-006702-ekf6mja9	432	17	controls	control	NNS
cord-006702-ekf6mja9	432	18	.	.	.
cord-006702-ekf6mja9	433	1	IFN	IFN	NNP
cord-006702-ekf6mja9	433	2	-	-	HYPH
cord-006702-ekf6mja9	433	3	γ	γ	NNP
cord-006702-ekf6mja9	433	4	+	+	CC
cord-006702-ekf6mja9	433	5	CD3	cd3	NN
cord-006702-ekf6mja9	433	6	+	+	CC
cord-006702-ekf6mja9	433	7	and	and	CC
cord-006702-ekf6mja9	434	1	IL-2	IL-2	NNP
cord-006702-ekf6mja9	434	2	+	+	SYM
cord-006702-ekf6mja9	434	3	CD3	CD3	NNP
cord-006702-ekf6mja9	434	4	+	+	CC
cord-006702-ekf6mja9	434	5	were	be	VBD
cord-006702-ekf6mja9	434	6	similarly	similarly	RB
cord-006702-ekf6mja9	434	7	decreased	decrease	VBN
cord-006702-ekf6mja9	434	8	in	in	IN
cord-006702-ekf6mja9	434	9	FSGS	FSGS	NNP
cord-006702-ekf6mja9	434	10	responders	responder	NNS
cord-006702-ekf6mja9	434	11	compared	compare	VBN
cord-006702-ekf6mja9	434	12	to	to	IN
cord-006702-ekf6mja9	434	13	nonresponders	nonresponder	NNS
cord-006702-ekf6mja9	434	14	,	,	,
cord-006702-ekf6mja9	434	15	MCNS	MCNS	NNP
cord-006702-ekf6mja9	434	16	and	and	CC
cord-006702-ekf6mja9	434	17	controls	control	NNS
cord-006702-ekf6mja9	434	18	.	.	.
cord-006702-ekf6mja9	435	1	Significant	significant	JJ
cord-006702-ekf6mja9	435	2	recovery	recovery	NN
cord-006702-ekf6mja9	435	3	of	of	IN
cord-006702-ekf6mja9	435	4	all	all	DT
cord-006702-ekf6mja9	435	5	3	3	CD
cord-006702-ekf6mja9	435	6	subsets	subset	NNS
cord-006702-ekf6mja9	435	7	in	in	IN
cord-006702-ekf6mja9	435	8	FSGS	FSGS	NNP
cord-006702-ekf6mja9	435	9	responders	responder	NNS
cord-006702-ekf6mja9	435	10	occurred	occur	VBD
cord-006702-ekf6mja9	435	11	6	6	CD
cord-006702-ekf6mja9	435	12	months	month	NNS
cord-006702-ekf6mja9	435	13	post	post	JJ
cord-006702-ekf6mja9	435	14	-	-	JJ
cord-006702-ekf6mja9	435	15	rituximab	rituximab	JJ
cord-006702-ekf6mja9	435	16	treatment	treatment	NN
cord-006702-ekf6mja9	435	17	.	.	.
cord-006702-ekf6mja9	436	1	Using	use	VBG
cord-006702-ekf6mja9	436	2	ROC	ROC	NNP
cord-006702-ekf6mja9	436	3	analysis	analysis	NN
cord-006702-ekf6mja9	436	4	,	,	,
cord-006702-ekf6mja9	436	5	activated	activate	VBD
cord-006702-ekf6mja9	436	6	CD154	CD154	NNP
cord-006702-ekf6mja9	437	1	+	+	CC
cord-006702-ekf6mja9	438	1	CD4	CD4	NNP
cord-006702-ekf6mja9	438	2	+	+	CC
cord-006702-ekf6mja9	438	3	CD3	CD3	NNP
cord-006702-ekf6mja9	439	1	+	+	CC
cord-006702-ekf6mja9	439	2	(	(	-LRB-
cord-006702-ekf6mja9	439	3	AUC	AUC	NNP
cord-006702-ekf6mja9	439	4	0.81	0.81	CD
cord-006702-ekf6mja9	439	5	,	,	,
cord-006702-ekf6mja9	439	6	95	95	CD
cord-006702-ekf6mja9	439	7	%	%	NN
cord-006702-ekf6mja9	439	8	CI	CI	NNP
cord-006702-ekf6mja9	439	9	0.61	0.61	CD
cord-006702-ekf6mja9	439	10	-	-	HYPH
cord-006702-ekf6mja9	439	11	1.01	1.01	CD
cord-006702-ekf6mja9	439	12	)	)	-RRB-
cord-006702-ekf6mja9	440	1	,	,	,
cord-006702-ekf6mja9	440	2	IFN	IFN	NNP
cord-006702-ekf6mja9	440	3	-	-	HYPH
cord-006702-ekf6mja9	440	4	γ	γ	NNP
cord-006702-ekf6mja9	440	5	+	+	CC
cord-006702-ekf6mja9	440	6	CD3	cd3	NN
cord-006702-ekf6mja9	441	1	+	+	CC
cord-006702-ekf6mja9	441	2	(	(	-LRB-
cord-006702-ekf6mja9	441	3	AUC	AUC	NNP
cord-006702-ekf6mja9	441	4	0.90	0.90	CD
cord-006702-ekf6mja9	441	5	,	,	,
cord-006702-ekf6mja9	441	6	95	95	CD
cord-006702-ekf6mja9	441	7	%	%	NN
cord-006702-ekf6mja9	441	8	CI	CI	NNP
cord-006702-ekf6mja9	441	9	0.75	0.75	CD
cord-006702-ekf6mja9	441	10	-	-	HYPH
cord-006702-ekf6mja9	441	11	1.05	1.05	CD
cord-006702-ekf6mja9	441	12	)	)	-RRB-
cord-006702-ekf6mja9	441	13	and	and	CC
cord-006702-ekf6mja9	442	1	IL-2	IL-2	NNP
cord-006702-ekf6mja9	442	2	+	+	SYM
cord-006702-ekf6mja9	442	3	CD3	CD3	NNP
cord-006702-ekf6mja9	442	4	+	+	CC
cord-006702-ekf6mja9	443	1	(	(	-LRB-
cord-006702-ekf6mja9	443	2	AUC	AUC	NNP
cord-006702-ekf6mja9	443	3	0.78	0.78	CD
cord-006702-ekf6mja9	443	4	,	,	,
cord-006702-ekf6mja9	443	5	95	95	CD
cord-006702-ekf6mja9	443	6	%	%	NN
cord-006702-ekf6mja9	443	7	CI	CI	NNP
cord-006702-ekf6mja9	443	8	0.57	0.57	CD
cord-006702-ekf6mja9	443	9	-	-	HYPH
cord-006702-ekf6mja9	443	10	0.98	0.98	CD
cord-006702-ekf6mja9	443	11	)	)	-RRB-
cord-006702-ekf6mja9	443	12	were	be	VBD
cord-006702-ekf6mja9	443	13	good	good	JJ
cord-006702-ekf6mja9	443	14	predictors	predictor	NNS
cord-006702-ekf6mja9	443	15	of	of	IN
cord-006702-ekf6mja9	443	16	response	response	NN
cord-006702-ekf6mja9	443	17	to	to	IN
cord-006702-ekf6mja9	443	18	rituximab	rituximab	NN
cord-006702-ekf6mja9	443	19	.	.	.
cord-006702-ekf6mja9	444	1	&	&	CC
cord-006702-ekf6mja9	444	2	Table	Table	NNP
cord-006702-ekf6mja9	444	3	1	1	CD
cord-006702-ekf6mja9	444	4	:	:	:
cord-006702-ekf6mja9	444	5	T	t	NN
cord-006702-ekf6mja9	444	6	-	-	HYPH
cord-006702-ekf6mja9	444	7	cell	cell	NN
cord-006702-ekf6mja9	444	8	activation	activation	NN
cord-006702-ekf6mja9	444	9	subsets	subset	NNS
cord-006702-ekf6mja9	444	10	pre	pre	VBP
cord-006702-ekf6mja9	444	11	-	-	JJ
cord-006702-ekf6mja9	444	12	rituximab	rituximab	JJ
cord-006702-ekf6mja9	444	13	and	and	CC
cord-006702-ekf6mja9	444	14	6	6	CD
cord-006702-ekf6mja9	444	15	months	month	NNS
cord-006702-ekf6mja9	444	16	postrituximab	postrituximab	NNS
cord-006702-ekf6mja9	444	17	in	in	IN
cord-006702-ekf6mja9	444	18	FSGS	FSGS	NNP
cord-006702-ekf6mja9	445	1	rituximab	rituximab	NNP
cord-006702-ekf6mja9	445	2	responders	responder	NNS
cord-006702-ekf6mja9	445	3	and	and	CC
cord-006702-ekf6mja9	445	4	non	non	NNS
cord-006702-ekf6mja9	445	5	-	-	NNS
cord-006702-ekf6mja9	445	6	responders	responder	NNS
cord-006702-ekf6mja9	445	7	compared	compare	VBN
cord-006702-ekf6mja9	445	8	to	to	IN
cord-006702-ekf6mja9	445	9	MCNS	MCNS	NNP
cord-006702-ekf6mja9	445	10	patients	patient	NNS
cord-006702-ekf6mja9	445	11	in	in	IN
cord-006702-ekf6mja9	445	12	relapse	relapse	NN
cord-006702-ekf6mja9	445	13	and	and	CC
cord-006702-ekf6mja9	445	14	healthy	healthy	JJ
cord-006702-ekf6mja9	445	15	controls	control	NNS
cord-006702-ekf6mja9	445	16	.	.	.
cord-006702-ekf6mja9	446	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	446	2	:	:	:
cord-006702-ekf6mja9	447	1	T	t	NN
cord-006702-ekf6mja9	447	2	-	-	HYPH
cord-006702-ekf6mja9	447	3	cell	cell	NN
cord-006702-ekf6mja9	447	4	subset	subset	VBN
cord-006702-ekf6mja9	447	5	hyporesponsiveness	hyporesponsiveness	NN
cord-006702-ekf6mja9	447	6	to	to	TO
cord-006702-ekf6mja9	447	7	mitogen	mitogen	NNP
cord-006702-ekf6mja9	447	8	stimulation	stimulation	NN
cord-006702-ekf6mja9	447	9	predicted	predict	VBD
cord-006702-ekf6mja9	447	10	a	a	DT
cord-006702-ekf6mja9	447	11	favorable	favorable	JJ
cord-006702-ekf6mja9	447	12	response	response	NN
cord-006702-ekf6mja9	447	13	to	to	IN
cord-006702-ekf6mja9	447	14	rituximab	rituximab	NN
cord-006702-ekf6mja9	447	15	in	in	IN
cord-006702-ekf6mja9	447	16	FSGS	FSGS	NNP
cord-006702-ekf6mja9	447	17	patients	patient	NNS
cord-006702-ekf6mja9	447	18	.	.	.
cord-006702-ekf6mja9	448	1	FP	FP	NNP
cord-006702-ekf6mja9	448	2	-	-	HYPH
cord-006702-ekf6mja9	448	3	S14	S14	NNP
cord-006702-ekf6mja9	448	4	-	-	HYPH
cord-006702-ekf6mja9	448	5	2	2	CD
cord-006702-ekf6mja9	448	6	Risk	risk	NN
cord-006702-ekf6mja9	448	7	factors	factor	NNS
cord-006702-ekf6mja9	448	8	for	for	IN
cord-006702-ekf6mja9	448	9	relapse	relapse	NN
cord-006702-ekf6mja9	448	10	after	after	IN
cord-006702-ekf6mja9	448	11	B	b	NN
cord-006702-ekf6mja9	448	12	-	-	HYPH
cord-006702-ekf6mja9	448	13	cell	cell	NN
cord-006702-ekf6mja9	448	14	recovery	recovery	NN
cord-006702-ekf6mja9	448	15	:	:	:
cord-006702-ekf6mja9	449	1	a	a	DT
cord-006702-ekf6mja9	449	2	course	course	NN
cord-006702-ekf6mja9	449	3	after	after	IN
cord-006702-ekf6mja9	449	4	rituximab	rituximab	JJ
cord-006702-ekf6mja9	449	5	treatment	treatment	NN
cord-006702-ekf6mja9	449	6	in	in	IN
cord-006702-ekf6mja9	449	7	children	child	NNS
cord-006702-ekf6mja9	449	8	with	with	IN
cord-006702-ekf6mja9	449	9	steroid	steroid	NN
cord-006702-ekf6mja9	449	10	-	-	HYPH
cord-006702-ekf6mja9	449	11	dependent	dependent	JJ
cord-006702-ekf6mja9	449	12	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	449	13	syndrome	syndrome	NN
cord-006702-ekf6mja9	449	14	H.	H.	NNP
cord-006702-ekf6mja9	449	15	Nagata	Nagata	NNP
cord-006702-ekf6mja9	449	16	(	(	-LRB-
cord-006702-ekf6mja9	449	17	1	1	CD
cord-006702-ekf6mja9	449	18	)	)	-RRB-
cord-006702-ekf6mja9	449	19	,	,	,
cord-006702-ekf6mja9	449	20	K.	K.	NNP
cord-006702-ekf6mja9	449	21	Kamei	Kamei	NNP
cord-006702-ekf6mja9	449	22	(	(	-LRB-
cord-006702-ekf6mja9	449	23	1	1	CD
cord-006702-ekf6mja9	449	24	)	)	-RRB-
cord-006702-ekf6mja9	449	25	,	,	,
cord-006702-ekf6mja9	449	26	T.	T.	NNP
cord-006702-ekf6mja9	449	27	Yoshikawa	Yoshikawa	NNP
cord-006702-ekf6mja9	449	28	(	(	-LRB-
cord-006702-ekf6mja9	449	29	1	1	CD
cord-006702-ekf6mja9	449	30	)	)	-RRB-
cord-006702-ekf6mja9	449	31	,	,	,
cord-006702-ekf6mja9	449	32	M.	M.	NNP
cord-006702-ekf6mja9	449	33	Sato	Sato	NNP
cord-006702-ekf6mja9	449	34	(	(	-LRB-
cord-006702-ekf6mja9	449	35	1	1	CD
cord-006702-ekf6mja9	449	36	)	)	-RRB-
cord-006702-ekf6mja9	449	37	,	,	,
cord-006702-ekf6mja9	449	38	M.	M.	NNP
cord-006702-ekf6mja9	449	39	Ogura	Ogura	NNP
cord-006702-ekf6mja9	449	40	(	(	-LRB-
cord-006702-ekf6mja9	449	41	1	1	CD
cord-006702-ekf6mja9	449	42	)	)	-RRB-
cord-006702-ekf6mja9	449	43	,	,	,
cord-006702-ekf6mja9	449	44	S.	S.	NNP
cord-006702-ekf6mja9	449	45	Ito	Ito	NNP
cord-006702-ekf6mja9	449	46	(	(	-LRB-
cord-006702-ekf6mja9	449	47	2	2	CD
cord-006702-ekf6mja9	449	48	)	)	-RRB-
cord-006702-ekf6mja9	449	49	,	,	,
cord-006702-ekf6mja9	449	50	K.	K.	NNP
cord-006702-ekf6mja9	449	51	Ishikura	Ishikura	NNP
cord-006702-ekf6mja9	449	52	(	(	-LRB-
cord-006702-ekf6mja9	449	53	1	1	CD
cord-006702-ekf6mja9	449	54	)	)	-RRB-
cord-006702-ekf6mja9	449	55	(	(	-LRB-
cord-006702-ekf6mja9	449	56	1	1	LS
cord-006702-ekf6mja9	449	57	)	)	-RRB-
cord-006702-ekf6mja9	449	58	National	National	NNP
cord-006702-ekf6mja9	449	59	Center	Center	NNP
cord-006702-ekf6mja9	449	60	for	for	IN
cord-006702-ekf6mja9	449	61	Child	Child	NNP
cord-006702-ekf6mja9	449	62	Health	Health	NNP
cord-006702-ekf6mja9	449	63	and	and	CC
cord-006702-ekf6mja9	449	64	Development	Development	NNP
cord-006702-ekf6mja9	449	65	,	,	,
cord-006702-ekf6mja9	449	66	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	449	67	,	,	,
cord-006702-ekf6mja9	449	68	Japan	Japan	NNP
cord-006702-ekf6mja9	449	69	;	;	:
cord-006702-ekf6mja9	449	70	(	(	-LRB-
cord-006702-ekf6mja9	449	71	2	2	LS
cord-006702-ekf6mja9	449	72	)	)	-RRB-
cord-006702-ekf6mja9	449	73	Department	Department	NNP
cord-006702-ekf6mja9	449	74	of	of	IN
cord-006702-ekf6mja9	449	75	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	449	76	,	,	,
cord-006702-ekf6mja9	449	77	Yokohama	Yokohama	NNP
cord-006702-ekf6mja9	449	78	City	City	NNP
cord-006702-ekf6mja9	449	79	University	University	NNP
cord-006702-ekf6mja9	449	80	School	School	NNP
cord-006702-ekf6mja9	449	81	of	of	IN
cord-006702-ekf6mja9	449	82	Medicine	Medicine	NNP
cord-006702-ekf6mja9	449	83	,	,	,
cord-006702-ekf6mja9	449	84	Yokohama	Yokohama	NNP
cord-006702-ekf6mja9	449	85	,	,	,
cord-006702-ekf6mja9	450	1	Japan	Japan	NNP
cord-006702-ekf6mja9	450	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	450	3	:	:	:
cord-006702-ekf6mja9	451	1	Rituximab	Rituximab	NNP
cord-006702-ekf6mja9	451	2	is	be	VBZ
cord-006702-ekf6mja9	451	3	used	use	VBN
cord-006702-ekf6mja9	451	4	for	for	IN
cord-006702-ekf6mja9	451	5	the	the	DT
cord-006702-ekf6mja9	451	6	treatment	treatment	NN
cord-006702-ekf6mja9	451	7	of	of	IN
cord-006702-ekf6mja9	451	8	refractory	refractory	JJ
cord-006702-ekf6mja9	451	9	steroiddependent	steroiddependent	NNP
cord-006702-ekf6mja9	451	10	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	451	11	syndrome	syndrome	NN
cord-006702-ekf6mja9	451	12	(	(	-LRB-
cord-006702-ekf6mja9	451	13	SDNS	SDNS	NNP
cord-006702-ekf6mja9	451	14	)	)	-RRB-
cord-006702-ekf6mja9	451	15	in	in	IN
cord-006702-ekf6mja9	451	16	children	child	NNS
cord-006702-ekf6mja9	451	17	.	.	.
cord-006702-ekf6mja9	452	1	We	-PRON-	PRP
cord-006702-ekf6mja9	452	2	have	have	VBP
cord-006702-ekf6mja9	452	3	previously	previously	RB
cord-006702-ekf6mja9	452	4	reported	report	VBN
cord-006702-ekf6mja9	452	5	that	that	IN
cord-006702-ekf6mja9	452	6	a	a	DT
cord-006702-ekf6mja9	452	7	history	history	NN
cord-006702-ekf6mja9	452	8	of	of	IN
cord-006702-ekf6mja9	452	9	steroid	steroid	JJ
cord-006702-ekf6mja9	452	10	resistant	resistant	JJ
cord-006702-ekf6mja9	452	11	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	452	12	syndrome	syndrome	NN
cord-006702-ekf6mja9	452	13	(	(	-LRB-
cord-006702-ekf6mja9	452	14	SRNS	SRNS	NNP
cord-006702-ekf6mja9	452	15	)	)	-RRB-
cord-006702-ekf6mja9	452	16	is	be	VBZ
cord-006702-ekf6mja9	452	17	a	a	DT
cord-006702-ekf6mja9	452	18	risk	risk	NN
cord-006702-ekf6mja9	452	19	factor	factor	NN
cord-006702-ekf6mja9	452	20	for	for	IN
cord-006702-ekf6mja9	452	21	early	early	JJ
cord-006702-ekf6mja9	452	22	relapse	relapse	NN
cord-006702-ekf6mja9	452	23	after	after	IN
cord-006702-ekf6mja9	452	24	the	the	DT
cord-006702-ekf6mja9	452	25	treatment	treatment	NN
cord-006702-ekf6mja9	452	26	of	of	IN
cord-006702-ekf6mja9	452	27	single	single	JJ
cord-006702-ekf6mja9	452	28	dose	dose	NN
cord-006702-ekf6mja9	452	29	of	of	IN
cord-006702-ekf6mja9	452	30	rituximab	rituximab	NN
cord-006702-ekf6mja9	452	31	followed	follow	VBN
cord-006702-ekf6mja9	452	32	by	by	IN
cord-006702-ekf6mja9	452	33	immunosuppressants	immunosuppressant	NNS
cord-006702-ekf6mja9	453	1	(	(	-LRB-
cord-006702-ekf6mja9	453	2	Kamei	Kamei	NNP
cord-006702-ekf6mja9	453	3	K	K	NNP
cord-006702-ekf6mja9	453	4	et	et	NNP
cord-006702-ekf6mja9	453	5	al	al	NNP
cord-006702-ekf6mja9	453	6	.	.	.
cord-006702-ekf6mja9	454	1	Pediatr	Pediatr	NNP
cord-006702-ekf6mja9	454	2	Nephrol	Nephrol	NNP
cord-006702-ekf6mja9	454	3	2016	2016	CD
cord-006702-ekf6mja9	454	4	)	)	-RRB-
cord-006702-ekf6mja9	454	5	.	.	.
cord-006702-ekf6mja9	455	1	However	however	RB
cord-006702-ekf6mja9	455	2	,	,	,
cord-006702-ekf6mja9	455	3	duration	duration	NN
cord-006702-ekf6mja9	455	4	of	of	IN
cord-006702-ekf6mja9	455	5	B	b	NN
cord-006702-ekf6mja9	455	6	-	-	HYPH
cord-006702-ekf6mja9	455	7	cell	cell	NN
cord-006702-ekf6mja9	455	8	depletion	depletion	NN
cord-006702-ekf6mja9	455	9	is	be	VBZ
cord-006702-ekf6mja9	455	10	different	different	JJ
cord-006702-ekf6mja9	455	11	between	between	IN
cord-006702-ekf6mja9	455	12	each	each	DT
cord-006702-ekf6mja9	455	13	patient	patient	NN
cord-006702-ekf6mja9	455	14	.	.	.
cord-006702-ekf6mja9	456	1	Here	here	RB
cord-006702-ekf6mja9	456	2	,	,	,
cord-006702-ekf6mja9	456	3	we	-PRON-	PRP
cord-006702-ekf6mja9	456	4	investigated	investigate	VBD
cord-006702-ekf6mja9	456	5	the	the	DT
cord-006702-ekf6mja9	456	6	duration	duration	NN
cord-006702-ekf6mja9	456	7	between	between	IN
cord-006702-ekf6mja9	456	8	B	b	NN
cord-006702-ekf6mja9	456	9	-	-	HYPH
cord-006702-ekf6mja9	456	10	cell	cell	NN
cord-006702-ekf6mja9	456	11	recovery	recovery	NN
cord-006702-ekf6mja9	456	12	and	and	CC
cord-006702-ekf6mja9	456	13	first	first	JJ
cord-006702-ekf6mja9	456	14	relapse	relapse	NN
cord-006702-ekf6mja9	456	15	and	and	CC
cord-006702-ekf6mja9	456	16	calculated	calculate	VBN
cord-006702-ekf6mja9	456	17	risk	risk	NN
cord-006702-ekf6mja9	456	18	factors	factor	NNS
cord-006702-ekf6mja9	456	19	for	for	IN
cord-006702-ekf6mja9	456	20	early	early	JJ
cord-006702-ekf6mja9	456	21	relapse	relapse	NN
cord-006702-ekf6mja9	456	22	after	after	IN
cord-006702-ekf6mja9	456	23	B	b	NN
cord-006702-ekf6mja9	456	24	-	-	HYPH
cord-006702-ekf6mja9	456	25	cell	cell	NN
cord-006702-ekf6mja9	456	26	recovery	recovery	NN
cord-006702-ekf6mja9	456	27	.	.	.
cord-006702-ekf6mja9	457	1	Methods	method	NNS
cord-006702-ekf6mja9	457	2	:	:	:
cord-006702-ekf6mja9	457	3	We	-PRON-	PRP
cord-006702-ekf6mja9	457	4	retrospectively	retrospectively	RB
cord-006702-ekf6mja9	457	5	reviewed	review	VBD
cord-006702-ekf6mja9	457	6	the	the	DT
cord-006702-ekf6mja9	457	7	medical	medical	JJ
cord-006702-ekf6mja9	457	8	records	record	NNS
cord-006702-ekf6mja9	457	9	of	of	IN
cord-006702-ekf6mja9	457	10	children	child	NNS
cord-006702-ekf6mja9	457	11	with	with	IN
cord-006702-ekf6mja9	457	12	refractory	refractory	JJ
cord-006702-ekf6mja9	457	13	SDNS	SDNS	NNP
cord-006702-ekf6mja9	457	14	who	who	WP
cord-006702-ekf6mja9	457	15	received	receive	VBD
cord-006702-ekf6mja9	457	16	a	a	DT
cord-006702-ekf6mja9	457	17	single	single	JJ
cord-006702-ekf6mja9	457	18	dose	dose	NN
cord-006702-ekf6mja9	457	19	of	of	IN
cord-006702-ekf6mja9	457	20	rituximab	rituximab	NN
cord-006702-ekf6mja9	457	21	(	(	-LRB-
cord-006702-ekf6mja9	457	22	375	375	CD
cord-006702-ekf6mja9	457	23	mg	mg	NNP
cord-006702-ekf6mja9	457	24	/	/	SYM
cord-006702-ekf6mja9	457	25	m	m	NNP
cord-006702-ekf6mja9	457	26	2	2	CD
cord-006702-ekf6mja9	457	27	)	)	-RRB-
cord-006702-ekf6mja9	457	28	between	between	IN
cord-006702-ekf6mja9	457	29	June	June	NNP
cord-006702-ekf6mja9	457	30	2007	2007	CD
cord-006702-ekf6mja9	457	31	and	and	CC
cord-006702-ekf6mja9	457	32	November	November	NNP
cord-006702-ekf6mja9	457	33	2013	2013	CD
cord-006702-ekf6mja9	457	34	.	.	.
cord-006702-ekf6mja9	458	1	All	all	DT
cord-006702-ekf6mja9	458	2	patients	patient	NNS
cord-006702-ekf6mja9	458	3	continued	continue	VBD
cord-006702-ekf6mja9	458	4	immunosuppressants	immunosuppressant	NNS
cord-006702-ekf6mja9	458	5	after	after	IN
cord-006702-ekf6mja9	458	6	rituximab	rituximab	JJ
cord-006702-ekf6mja9	458	7	treatment	treatment	NN
cord-006702-ekf6mja9	458	8	.	.	.
cord-006702-ekf6mja9	459	1	B	b	NN
cord-006702-ekf6mja9	459	2	-	-	HYPH
cord-006702-ekf6mja9	459	3	cell	cell	NN
cord-006702-ekf6mja9	459	4	recovery	recovery	NN
cord-006702-ekf6mja9	459	5	was	be	VBD
cord-006702-ekf6mja9	459	6	defined	define	VBN
cord-006702-ekf6mja9	459	7	as	as	IN
cord-006702-ekf6mja9	459	8	CD19>1	cd19>1	NN
cord-006702-ekf6mja9	459	9	%	%	NN
cord-006702-ekf6mja9	459	10	lymphocyte	lymphocyte	NN
cord-006702-ekf6mja9	459	11	after	after	IN
cord-006702-ekf6mja9	459	12	rituximab	rituximab	JJ
cord-006702-ekf6mja9	459	13	treatment	treatment	NN
cord-006702-ekf6mja9	459	14	.	.	.
cord-006702-ekf6mja9	460	1	Kaplan	Kaplan	NNP
cord-006702-ekf6mja9	460	2	-	-	HYPH
cord-006702-ekf6mja9	460	3	Meier	Meier	NNP
cord-006702-ekf6mja9	460	4	analyses	analysis	NNS
cord-006702-ekf6mja9	460	5	for	for	IN
cord-006702-ekf6mja9	460	6	relapse	relapse	NN
cord-006702-ekf6mja9	460	7	after	after	IN
cord-006702-ekf6mja9	460	8	B	b	NN
cord-006702-ekf6mja9	460	9	-	-	HYPH
cord-006702-ekf6mja9	460	10	cell	cell	NN
cord-006702-ekf6mja9	460	11	recovery	recovery	NN
cord-006702-ekf6mja9	460	12	were	be	VBD
cord-006702-ekf6mja9	460	13	conducted	conduct	VBN
cord-006702-ekf6mja9	460	14	.	.	.
cord-006702-ekf6mja9	461	1	The	the	DT
cord-006702-ekf6mja9	461	2	differences	difference	NNS
cord-006702-ekf6mja9	461	3	between	between	IN
cord-006702-ekf6mja9	461	4	groups	group	NNS
cord-006702-ekf6mja9	461	5	(	(	-LRB-
cord-006702-ekf6mja9	461	6	history	history	NN
cord-006702-ekf6mja9	461	7	of	of	IN
cord-006702-ekf6mja9	461	8	SRNS	SRNS	NNP
cord-006702-ekf6mja9	461	9	(	(	-LRB-
cord-006702-ekf6mja9	461	10	SR	SR	NNP
cord-006702-ekf6mja9	461	11	)	)	-RRB-
cord-006702-ekf6mja9	461	12	vs.	vs.	CC
cord-006702-ekf6mja9	461	13	no	no	DT
cord-006702-ekf6mja9	461	14	history	history	NN
cord-006702-ekf6mja9	461	15	of	of	IN
cord-006702-ekf6mja9	461	16	SRNS(nSR	SRNS(nSR	NNP
cord-006702-ekf6mja9	461	17	)	)	-RRB-
cord-006702-ekf6mja9	461	18	)	)	-RRB-
cord-006702-ekf6mja9	461	19	were	be	VBD
cord-006702-ekf6mja9	461	20	compared	compare	VBN
cord-006702-ekf6mja9	461	21	using	use	VBG
cord-006702-ekf6mja9	461	22	the	the	DT
cord-006702-ekf6mja9	461	23	log	log	NN
cord-006702-ekf6mja9	461	24	-	-	HYPH
cord-006702-ekf6mja9	461	25	rank	rank	NN
cord-006702-ekf6mja9	461	26	test	test	NN
cord-006702-ekf6mja9	461	27	.	.	.
cord-006702-ekf6mja9	462	1	Hazard	hazard	NN
cord-006702-ekf6mja9	462	2	ratio	ratio	NN
cord-006702-ekf6mja9	462	3	and	and	CC
cord-006702-ekf6mja9	462	4	95	95	CD
cord-006702-ekf6mja9	462	5	%	%	NN
cord-006702-ekf6mja9	462	6	confidence	confidence	NN
cord-006702-ekf6mja9	462	7	interval	interval	NN
cord-006702-ekf6mja9	462	8	(	(	-LRB-
cord-006702-ekf6mja9	462	9	CI	CI	NNP
cord-006702-ekf6mja9	462	10	)	)	-RRB-
cord-006702-ekf6mja9	462	11	for	for	IN
cord-006702-ekf6mja9	462	12	relapse	relapse	NN
cord-006702-ekf6mja9	462	13	after	after	IN
cord-006702-ekf6mja9	462	14	B	b	NN
cord-006702-ekf6mja9	462	15	-	-	HYPH
cord-006702-ekf6mja9	462	16	cell	cell	NN
cord-006702-ekf6mja9	462	17	recovery	recovery	NN
cord-006702-ekf6mja9	462	18	was	be	VBD
cord-006702-ekf6mja9	462	19	evaluated	evaluate	VBN
cord-006702-ekf6mja9	462	20	by	by	IN
cord-006702-ekf6mja9	462	21	the	the	DT
cord-006702-ekf6mja9	462	22	Cox	Cox	NNP
cord-006702-ekf6mja9	462	23	regression	regression	NN
cord-006702-ekf6mja9	462	24	analysis	analysis	NN
cord-006702-ekf6mja9	462	25	.	.	.
cord-006702-ekf6mja9	463	1	Results	result	NNS
cord-006702-ekf6mja9	463	2	:	:	:
cord-006702-ekf6mja9	464	1	Fifty	fifty	CD
cord-006702-ekf6mja9	464	2	-	-	HYPH
cord-006702-ekf6mja9	464	3	five	five	CD
cord-006702-ekf6mja9	464	4	patients	patient	NNS
cord-006702-ekf6mja9	464	5	(	(	-LRB-
cord-006702-ekf6mja9	464	6	40	40	CD
cord-006702-ekf6mja9	464	7	boys	boy	NNS
cord-006702-ekf6mja9	464	8	and	and	CC
cord-006702-ekf6mja9	464	9	15	15	CD
cord-006702-ekf6mja9	464	10	girls	girl	NNS
cord-006702-ekf6mja9	464	11	)	)	-RRB-
cord-006702-ekf6mja9	464	12	received	receive	VBD
cord-006702-ekf6mja9	464	13	rituximab	rituximab	NN
cord-006702-ekf6mja9	464	14	.	.	.
cord-006702-ekf6mja9	465	1	The	the	DT
cord-006702-ekf6mja9	465	2	median	median	JJ
cord-006702-ekf6mja9	465	3	follow	follow	NN
cord-006702-ekf6mja9	465	4	-	-	HYPH
cord-006702-ekf6mja9	465	5	up	up	NN
cord-006702-ekf6mja9	465	6	period	period	NN
cord-006702-ekf6mja9	465	7	were	be	VBD
cord-006702-ekf6mja9	465	8	308	308	CD
cord-006702-ekf6mja9	465	9	days	day	NNS
cord-006702-ekf6mja9	465	10	(	(	-LRB-
cord-006702-ekf6mja9	465	11	35	35	CD
cord-006702-ekf6mja9	465	12	-	-	SYM
cord-006702-ekf6mja9	465	13	2,505	2,505	CD
cord-006702-ekf6mja9	465	14	days	day	NNS
cord-006702-ekf6mja9	465	15	)	)	-RRB-
cord-006702-ekf6mja9	465	16	.	.	.
cord-006702-ekf6mja9	466	1	Fifty	fifty	CD
cord-006702-ekf6mja9	466	2	-	-	HYPH
cord-006702-ekf6mja9	466	3	percent	percent	NN
cord-006702-ekf6mja9	466	4	relapse	relapse	NN
cord-006702-ekf6mja9	466	5	free	free	JJ
cord-006702-ekf6mja9	466	6	survival	survival	NN
cord-006702-ekf6mja9	466	7	was	be	VBD
cord-006702-ekf6mja9	466	8	significantly	significantly	RB
cord-006702-ekf6mja9	466	9	shorter	short	JJR
cord-006702-ekf6mja9	466	10	in	in	IN
cord-006702-ekf6mja9	466	11	SR	SR	NNP
cord-006702-ekf6mja9	466	12	than	than	IN
cord-006702-ekf6mja9	466	13	in	in	IN
cord-006702-ekf6mja9	466	14	nSR	nSR	NNP
cord-006702-ekf6mja9	466	15	(	(	-LRB-
cord-006702-ekf6mja9	466	16	238	238	CD
cord-006702-ekf6mja9	466	17	days	day	NNS
cord-006702-ekf6mja9	466	18	vs.	vs.	CC
cord-006702-ekf6mja9	466	19	1,001	1,001	CD
cord-006702-ekf6mja9	466	20	days	day	NNS
cord-006702-ekf6mja9	466	21	,	,	,
cord-006702-ekf6mja9	466	22	p=0.014	p=0.014	NNS
cord-006702-ekf6mja9	466	23	)	)	-RRB-
cord-006702-ekf6mja9	467	1	(	(	-LRB-
cord-006702-ekf6mja9	467	2	Figure	figure	NN
cord-006702-ekf6mja9	467	3	1	1	CD
cord-006702-ekf6mja9	467	4	)	)	-RRB-
cord-006702-ekf6mja9	467	5	.	.	.
cord-006702-ekf6mja9	468	1	Results	result	NNS
cord-006702-ekf6mja9	468	2	of	of	IN
cord-006702-ekf6mja9	468	3	Cox	Cox	NNP
cord-006702-ekf6mja9	468	4	regression	regression	NN
cord-006702-ekf6mja9	468	5	are	be	VBP
cord-006702-ekf6mja9	468	6	shown	show	VBN
cord-006702-ekf6mja9	468	7	in	in	IN
cord-006702-ekf6mja9	468	8	Table	Table	NNP
cord-006702-ekf6mja9	468	9	1	1	CD
cord-006702-ekf6mja9	468	10	.	.	.
cord-006702-ekf6mja9	469	1	Controlling	control	VBG
cord-006702-ekf6mja9	469	2	for	for	IN
cord-006702-ekf6mja9	469	3	age	age	NN
cord-006702-ekf6mja9	469	4	of	of	IN
cord-006702-ekf6mja9	469	5	onset	onset	NN
cord-006702-ekf6mja9	469	6	,	,	,
cord-006702-ekf6mja9	469	7	age	age	NN
cord-006702-ekf6mja9	469	8	at	at	IN
cord-006702-ekf6mja9	469	9	rituximab	rituximab	NNP
cord-006702-ekf6mja9	469	10	administration	administration	NN
cord-006702-ekf6mja9	469	11	,	,	,
cord-006702-ekf6mja9	469	12	gender	gender	NN
cord-006702-ekf6mja9	469	13	and	and	CC
cord-006702-ekf6mja9	469	14	renal	renal	JJ
cord-006702-ekf6mja9	469	15	histology	histology	NN
cord-006702-ekf6mja9	469	16	,	,	,
cord-006702-ekf6mja9	469	17	the	the	DT
cord-006702-ekf6mja9	469	18	risk	risk	NN
cord-006702-ekf6mja9	469	19	ratio	ratio	NN
cord-006702-ekf6mja9	469	20	of	of	IN
cord-006702-ekf6mja9	469	21	a	a	DT
cord-006702-ekf6mja9	469	22	history	history	NN
cord-006702-ekf6mja9	469	23	of	of	IN
cord-006702-ekf6mja9	469	24	SRNS	SRNS	NNP
cord-006702-ekf6mja9	469	25	for	for	IN
cord-006702-ekf6mja9	469	26	relapse	relapse	NN
cord-006702-ekf6mja9	469	27	after	after	IN
cord-006702-ekf6mja9	469	28	B	b	NN
cord-006702-ekf6mja9	469	29	-	-	HYPH
cord-006702-ekf6mja9	469	30	cell	cell	NN
cord-006702-ekf6mja9	469	31	recovery	recovery	NN
cord-006702-ekf6mja9	469	32	was	be	VBD
cord-006702-ekf6mja9	469	33	2.96	2.96	CD
cord-006702-ekf6mja9	470	1	(	(	-LRB-
cord-006702-ekf6mja9	470	2	95	95	CD
cord-006702-ekf6mja9	470	3	%	%	NN
cord-006702-ekf6mja9	470	4	CI	CI	NNP
cord-006702-ekf6mja9	470	5	,	,	,
cord-006702-ekf6mja9	470	6	1.38	1.38	CD
cord-006702-ekf6mja9	470	7	-	-	SYM
cord-006702-ekf6mja9	470	8	6.62	6.62	CD
cord-006702-ekf6mja9	470	9	;	;	:
cord-006702-ekf6mja9	470	10	p=0.005	p=0.005	NNP
cord-006702-ekf6mja9	470	11	)	)	-RRB-
cord-006702-ekf6mja9	470	12	.	.	.
cord-006702-ekf6mja9	471	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	471	2	:	:	:
cord-006702-ekf6mja9	472	1	A	a	DT
cord-006702-ekf6mja9	472	2	total	total	NN
cord-006702-ekf6mja9	472	3	of	of	IN
cord-006702-ekf6mja9	472	4	71.2	71.2	CD
cord-006702-ekf6mja9	472	5	%	%	NN
cord-006702-ekf6mja9	472	6	of	of	IN
cord-006702-ekf6mja9	472	7	the	the	DT
cord-006702-ekf6mja9	472	8	children	child	NNS
cord-006702-ekf6mja9	472	9	experienced	experience	VBD
cord-006702-ekf6mja9	472	10	NS	NS	NNP
cord-006702-ekf6mja9	472	11	relapse	relapse	NN
cord-006702-ekf6mja9	472	12	in	in	IN
cord-006702-ekf6mja9	472	13	3	3	CD
cord-006702-ekf6mja9	472	14	years	year	NNS
cord-006702-ekf6mja9	472	15	after	after	IN
cord-006702-ekf6mja9	472	16	B	b	NN
cord-006702-ekf6mja9	472	17	-	-	HYPH
cord-006702-ekf6mja9	472	18	cell	cell	NN
cord-006702-ekf6mja9	472	19	recovery	recovery	NN
cord-006702-ekf6mja9	472	20	.	.	.
cord-006702-ekf6mja9	473	1	A	a	DT
cord-006702-ekf6mja9	473	2	history	history	NN
cord-006702-ekf6mja9	473	3	of	of	IN
cord-006702-ekf6mja9	473	4	SRNS	SRNS	NNP
cord-006702-ekf6mja9	473	5	was	be	VBD
cord-006702-ekf6mja9	473	6	a	a	DT
cord-006702-ekf6mja9	473	7	significant	significant	JJ
cord-006702-ekf6mja9	473	8	risk	risk	NN
cord-006702-ekf6mja9	473	9	factor	factor	NN
cord-006702-ekf6mja9	473	10	for	for	IN
cord-006702-ekf6mja9	473	11	early	early	JJ
cord-006702-ekf6mja9	473	12	relapse	relapse	NN
cord-006702-ekf6mja9	473	13	.	.	.
cord-006702-ekf6mja9	474	1	Intensified	intensify	VBN
cord-006702-ekf6mja9	474	2	immunosuppressants	immunosuppressant	NNS
cord-006702-ekf6mja9	474	3	with	with	IN
cord-006702-ekf6mja9	474	4	rituximab	rituximab	NN
cord-006702-ekf6mja9	474	5	may	may	MD
cord-006702-ekf6mja9	474	6	be	be	VB
cord-006702-ekf6mja9	474	7	beneficial	beneficial	JJ
cord-006702-ekf6mja9	474	8	for	for	IN
cord-006702-ekf6mja9	474	9	these	these	DT
cord-006702-ekf6mja9	474	10	patients	patient	NNS
cord-006702-ekf6mja9	474	11	to	to	TO
cord-006702-ekf6mja9	474	12	prevent	prevent	VB
cord-006702-ekf6mja9	474	13	early	early	JJ
cord-006702-ekf6mja9	474	14	relapse	relapse	NN
cord-006702-ekf6mja9	474	15	after	after	IN
cord-006702-ekf6mja9	474	16	B	b	NN
cord-006702-ekf6mja9	474	17	-	-	HYPH
cord-006702-ekf6mja9	474	18	cell	cell	NN
cord-006702-ekf6mja9	474	19	recovery	recovery	NN
cord-006702-ekf6mja9	474	20	.	.	.
cord-006702-ekf6mja9	475	1	FP	FP	NNP
cord-006702-ekf6mja9	475	2	-	-	HYPH
cord-006702-ekf6mja9	475	3	S14	S14	NNP
cord-006702-ekf6mja9	475	4	-	-	HYPH
cord-006702-ekf6mja9	475	5	3	3	CD
cord-006702-ekf6mja9	475	6	Effect	Effect	NNP
cord-006702-ekf6mja9	475	7	of	of	IN
cord-006702-ekf6mja9	475	8	atorvastatin	atorvastatin	NN
cord-006702-ekf6mja9	475	9	on	on	IN
cord-006702-ekf6mja9	475	10	lipid	lipid	NN
cord-006702-ekf6mja9	475	11	profile	profile	NN
cord-006702-ekf6mja9	475	12	and	and	CC
cord-006702-ekf6mja9	475	13	carotid	carotid	JJ
cord-006702-ekf6mja9	475	14	intima	intima	NN
cord-006702-ekf6mja9	475	15	media	medium	NNS
cord-006702-ekf6mja9	475	16	thickness	thickness	NN
cord-006702-ekf6mja9	475	17	(	(	-LRB-
cord-006702-ekf6mja9	475	18	cIMT	cIMT	VBN
cord-006702-ekf6mja9	475	19	)	)	-RRB-
cord-006702-ekf6mja9	475	20	in	in	IN
cord-006702-ekf6mja9	475	21	children	child	NNS
cord-006702-ekf6mja9	475	22	with	with	IN
cord-006702-ekf6mja9	475	23	refractory	refractory	JJ
cord-006702-ekf6mja9	475	24	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	475	25	syndrome	syndrome	NN
cord-006702-ekf6mja9	475	26	:	:	:
cord-006702-ekf6mja9	475	27	a	a	DT
cord-006702-ekf6mja9	475	28	randomized	randomized	JJ
cord-006702-ekf6mja9	475	29	double	double	JJ
cord-006702-ekf6mja9	475	30	blind	blind	JJ
cord-006702-ekf6mja9	475	31	,	,	,
cord-006702-ekf6mja9	475	32	placebo	placebo	NN
cord-006702-ekf6mja9	475	33	controlled	control	VBN
cord-006702-ekf6mja9	475	34	,	,	,
cord-006702-ekf6mja9	475	35	trial	trial	NN
cord-006702-ekf6mja9	475	36	P.	P.	NNP
cord-006702-ekf6mja9	475	37	Hari	Hari	NNP
cord-006702-ekf6mja9	475	38	,	,	,
cord-006702-ekf6mja9	475	39	A.	A.	NNP
cord-006702-ekf6mja9	475	40	Satpathy	Satpathy	NNP
cord-006702-ekf6mja9	475	41	,	,	,
cord-006702-ekf6mja9	475	42	R.	R.	NNP
cord-006702-ekf6mja9	475	43	Thergaonkar	Thergaonkar	NNP
cord-006702-ekf6mja9	475	44	,	,	,
cord-006702-ekf6mja9	475	45	P.	P.	NNP
cord-006702-ekf6mja9	475	46	Khandelwal	Khandelwal	NNP
cord-006702-ekf6mja9	475	47	,	,	,
cord-006702-ekf6mja9	475	48	S.	S.	NNP
cord-006702-ekf6mja9	475	49	Hari	Hari	NNP
cord-006702-ekf6mja9	475	50	,	,	,
cord-006702-ekf6mja9	475	51	R.	R.	NNP
cord-006702-ekf6mja9	475	52	Lakshmy	Lakshmy	NNP
cord-006702-ekf6mja9	475	53	,	,	,
cord-006702-ekf6mja9	475	54	A.	a.	NN
cord-006702-ekf6mja9	475	55	Sinha	Sinha	NNP
cord-006702-ekf6mja9	475	56	,	,	,
cord-006702-ekf6mja9	475	57	A.	A.	NNP
cord-006702-ekf6mja9	475	58	Bagga	Bagga	NNP
cord-006702-ekf6mja9	476	1	All	all	DT
cord-006702-ekf6mja9	476	2	India	India	NNP
cord-006702-ekf6mja9	476	3	Institue	Institue	NNP
cord-006702-ekf6mja9	476	4	of	of	IN
cord-006702-ekf6mja9	476	5	Medical	Medical	NNP
cord-006702-ekf6mja9	476	6	Sciences	Sciences	NNPS
cord-006702-ekf6mja9	476	7	,	,	,
cord-006702-ekf6mja9	476	8	Delhi	Delhi	NNP
cord-006702-ekf6mja9	476	9	,	,	,
cord-006702-ekf6mja9	477	1	India	India	NNP
cord-006702-ekf6mja9	477	2	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	477	3	:	:	:
cord-006702-ekf6mja9	478	1	Role	role	NN
cord-006702-ekf6mja9	478	2	of	of	IN
cord-006702-ekf6mja9	478	3	statins	statin	NNS
cord-006702-ekf6mja9	478	4	for	for	IN
cord-006702-ekf6mja9	478	5	treatment	treatment	NN
cord-006702-ekf6mja9	478	6	of	of	IN
cord-006702-ekf6mja9	478	7	hyperlipidemia	hyperlipidemia	NN
cord-006702-ekf6mja9	478	8	in	in	IN
cord-006702-ekf6mja9	478	9	children	child	NNS
cord-006702-ekf6mja9	478	10	with	with	IN
cord-006702-ekf6mja9	478	11	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	478	12	syndrome	syndrome	NN
cord-006702-ekf6mja9	478	13	is	be	VBZ
cord-006702-ekf6mja9	478	14	unclear	unclear	JJ
cord-006702-ekf6mja9	478	15	.	.	.
cord-006702-ekf6mja9	479	1	We	-PRON-	PRP
cord-006702-ekf6mja9	479	2	examined	examine	VBD
cord-006702-ekf6mja9	479	3	the	the	DT
cord-006702-ekf6mja9	479	4	lipid	lipid	NN
cord-006702-ekf6mja9	479	5	-	-	HYPH
cord-006702-ekf6mja9	479	6	lowering	lower	VBG
cord-006702-ekf6mja9	479	7	efficacy	efficacy	NN
cord-006702-ekf6mja9	479	8	of	of	IN
cord-006702-ekf6mja9	479	9	atorvastatin	atorvastatin	NN
cord-006702-ekf6mja9	479	10	and	and	CC
cord-006702-ekf6mja9	479	11	its	-PRON-	PRP$
cord-006702-ekf6mja9	479	12	effect	effect	NN
cord-006702-ekf6mja9	479	13	on	on	IN
cord-006702-ekf6mja9	479	14	the	the	DT
cord-006702-ekf6mja9	479	15	cIMT	cimt	JJ
cord-006702-ekf6mja9	479	16	and	and	CC
cord-006702-ekf6mja9	479	17	brachial	brachial	JJ
cord-006702-ekf6mja9	479	18	artery	artery	NN
cord-006702-ekf6mja9	479	19	flow	flow	NN
cord-006702-ekf6mja9	479	20	mediated	mediate	VBN
cord-006702-ekf6mja9	479	21	dilatation	dilatation	NN
cord-006702-ekf6mja9	479	22	(	(	-LRB-
cord-006702-ekf6mja9	479	23	FMD	FMD	NNP
cord-006702-ekf6mja9	479	24	)	)	-RRB-
cord-006702-ekf6mja9	479	25	and	and	CC
cord-006702-ekf6mja9	479	26	safety	safety	NN
cord-006702-ekf6mja9	479	27	in	in	IN
cord-006702-ekf6mja9	479	28	children	child	NNS
cord-006702-ekf6mja9	479	29	with	with	IN
cord-006702-ekf6mja9	479	30	refractory	refractory	JJ
cord-006702-ekf6mja9	479	31	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	479	32	syndrome	syndrome	NN
cord-006702-ekf6mja9	479	33	and	and	CC
cord-006702-ekf6mja9	479	34	hyperlipidemia	hyperlipidemia	NN
cord-006702-ekf6mja9	479	35	.	.	.
cord-006702-ekf6mja9	480	1	Methods	method	NNS
cord-006702-ekf6mja9	480	2	:	:	:
cord-006702-ekf6mja9	480	3	Children	child	NNS
cord-006702-ekf6mja9	480	4	with	with	IN
cord-006702-ekf6mja9	480	5	refractory	refractory	JJ
cord-006702-ekf6mja9	480	6	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	480	7	syndrome	syndrome	NN
cord-006702-ekf6mja9	480	8	and	and	CC
cord-006702-ekf6mja9	480	9	LDL	ldl	NN
cord-006702-ekf6mja9	480	10	-	-	HYPH
cord-006702-ekf6mja9	480	11	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	480	12	(	(	-LRB-
cord-006702-ekf6mja9	480	13	LDL	LDL	NNP
cord-006702-ekf6mja9	480	14	-	-	HYPH
cord-006702-ekf6mja9	480	15	C	C	NNP
cord-006702-ekf6mja9	480	16	)	)	-RRB-
cord-006702-ekf6mja9	481	1	>	>	XX
cord-006702-ekf6mja9	482	1	130	130	CD
cord-006702-ekf6mja9	482	2	mg	mg	NNP
cord-006702-ekf6mja9	482	3	/	/	SYM
cord-006702-ekf6mja9	482	4	dl	dl	NNP
cord-006702-ekf6mja9	482	5	were	be	VBD
cord-006702-ekf6mja9	482	6	randomized	randomize	VBN
cord-006702-ekf6mja9	482	7	to	to	TO
cord-006702-ekf6mja9	482	8	receive	receive	VB
cord-006702-ekf6mja9	482	9	atorvastatin	atorvastatin	NNP
cord-006702-ekf6mja9	482	10	(	(	-LRB-
cord-006702-ekf6mja9	482	11	10	10	CD
cord-006702-ekf6mja9	482	12	mg	mg	NNP
cord-006702-ekf6mja9	482	13	/	/	SYM
cord-006702-ekf6mja9	482	14	day	day	NN
cord-006702-ekf6mja9	482	15	)	)	-RRB-
cord-006702-ekf6mja9	482	16	or	or	CC
cord-006702-ekf6mja9	482	17	placebo	placebo	NN
cord-006702-ekf6mja9	482	18	for	for	IN
cord-006702-ekf6mja9	482	19	1	1	CD
cord-006702-ekf6mja9	482	20	year	year	NN
cord-006702-ekf6mja9	482	21	.	.	.
cord-006702-ekf6mja9	483	1	Lipid	lipid	NN
cord-006702-ekf6mja9	483	2	,	,	,
cord-006702-ekf6mja9	483	3	creatinine	creatinine	NN
cord-006702-ekf6mja9	483	4	phosphokinase	phosphokinase	NN
cord-006702-ekf6mja9	483	5	(	(	-LRB-
cord-006702-ekf6mja9	483	6	CPK	CPK	NNP
cord-006702-ekf6mja9	483	7	)	)	-RRB-
cord-006702-ekf6mja9	483	8	,	,	,
cord-006702-ekf6mja9	483	9	serum	serum	NN
cord-006702-ekf6mja9	483	10	albumin	albumin	NN
cord-006702-ekf6mja9	483	11	,	,	,
cord-006702-ekf6mja9	483	12	transaminase	transaminase	FW
cord-006702-ekf6mja9	483	13	,	,	,
cord-006702-ekf6mja9	483	14	C	c	NN
cord-006702-ekf6mja9	483	15	-	-	HYPH
cord-006702-ekf6mja9	483	16	reactive	reactive	JJ
cord-006702-ekf6mja9	483	17	protein	protein	NN
cord-006702-ekf6mja9	483	18	(	(	-LRB-
cord-006702-ekf6mja9	483	19	CRP	CRP	NNP
cord-006702-ekf6mja9	483	20	)	)	-RRB-
cord-006702-ekf6mja9	483	21	levels	level	NNS
cord-006702-ekf6mja9	483	22	and	and	CC
cord-006702-ekf6mja9	483	23	estimated	estimate	VBN
cord-006702-ekf6mja9	483	24	GFR	GFR	NNP
cord-006702-ekf6mja9	483	25	were	be	VBD
cord-006702-ekf6mja9	483	26	measured	measure	VBN
cord-006702-ekf6mja9	483	27	at	at	IN
cord-006702-ekf6mja9	483	28	baseline	baseline	NN
cord-006702-ekf6mja9	483	29	,	,	,
cord-006702-ekf6mja9	483	30	3	3	CD
cord-006702-ekf6mja9	483	31	,	,	,
cord-006702-ekf6mja9	483	32	6	6	CD
cord-006702-ekf6mja9	483	33	and	and	CC
cord-006702-ekf6mja9	483	34	12	12	CD
cord-006702-ekf6mja9	483	35	months	month	NNS
cord-006702-ekf6mja9	483	36	;	;	:
cord-006702-ekf6mja9	483	37	cIMT	cimt	NN
cord-006702-ekf6mja9	483	38	and	and	CC
cord-006702-ekf6mja9	483	39	brachial	brachial	JJ
cord-006702-ekf6mja9	483	40	artery	artery	NN
cord-006702-ekf6mja9	483	41	FMD	FMD	NNP
cord-006702-ekf6mja9	483	42	was	be	VBD
cord-006702-ekf6mja9	483	43	measured	measure	VBN
cord-006702-ekf6mja9	483	44	at	at	IN
cord-006702-ekf6mja9	483	45	baseline	baseline	NN
cord-006702-ekf6mja9	483	46	,	,	,
cord-006702-ekf6mja9	483	47	6	6	CD
cord-006702-ekf6mja9	483	48	and	and	CC
cord-006702-ekf6mja9	483	49	12	12	CD
cord-006702-ekf6mja9	483	50	months	month	NNS
cord-006702-ekf6mja9	483	51	.	.	.
cord-006702-ekf6mja9	484	1	Primary	primary	JJ
cord-006702-ekf6mja9	484	2	outcome	outcome	NN
cord-006702-ekf6mja9	484	3	was	be	VBD
cord-006702-ekf6mja9	484	4	mean	mean	JJ
cord-006702-ekf6mja9	484	5	difference	difference	NN
cord-006702-ekf6mja9	484	6	in	in	IN
cord-006702-ekf6mja9	484	7	reduction	reduction	NN
cord-006702-ekf6mja9	484	8	of	of	IN
cord-006702-ekf6mja9	484	9	lipid	lipid	NN
cord-006702-ekf6mja9	484	10	levels	level	NNS
cord-006702-ekf6mja9	484	11	,	,	,
cord-006702-ekf6mja9	484	12	cIMT	cimt	JJ
cord-006702-ekf6mja9	484	13	and	and	CC
cord-006702-ekf6mja9	484	14	brachial	brachial	JJ
cord-006702-ekf6mja9	484	15	artery	artery	NN
cord-006702-ekf6mja9	484	16	FMD	FMD	NNP
cord-006702-ekf6mja9	484	17	.	.	.
cord-006702-ekf6mja9	485	1	Results	result	NNS
cord-006702-ekf6mja9	485	2	:	:	:
cord-006702-ekf6mja9	485	3	30	30	CD
cord-006702-ekf6mja9	485	4	children	child	NNS
cord-006702-ekf6mja9	485	5	(	(	-LRB-
cord-006702-ekf6mja9	485	6	mean	mean	VB
cord-006702-ekf6mja9	485	7	age	age	NN
cord-006702-ekf6mja9	485	8	11.4	11.4	CD
cord-006702-ekf6mja9	485	9	yr	yr	NNS
cord-006702-ekf6mja9	485	10	)	)	-RRB-
cord-006702-ekf6mja9	485	11	were	be	VBD
cord-006702-ekf6mja9	485	12	included	include	VBN
cord-006702-ekf6mja9	485	13	;	;	:
cord-006702-ekf6mja9	485	14	15	15	CD
cord-006702-ekf6mja9	485	15	each	each	DT
cord-006702-ekf6mja9	485	16	were	be	VBD
cord-006702-ekf6mja9	485	17	randomized	randomize	VBN
cord-006702-ekf6mja9	485	18	to	to	TO
cord-006702-ekf6mja9	485	19	receive	receive	VB
cord-006702-ekf6mja9	485	20	either	either	CC
cord-006702-ekf6mja9	485	21	atorvastatin	atorvastatin	NN
cord-006702-ekf6mja9	485	22	or	or	CC
cord-006702-ekf6mja9	485	23	placebo	placebo	NN
cord-006702-ekf6mja9	485	24	(	(	-LRB-
cord-006702-ekf6mja9	485	25	Figure	figure	NN
cord-006702-ekf6mja9	485	26	1	1	CD
cord-006702-ekf6mja9	485	27	)	)	-RRB-
cord-006702-ekf6mja9	485	28	.	.	.
cord-006702-ekf6mja9	486	1	Baseline	baseline	JJ
cord-006702-ekf6mja9	486	2	characteristics	characteristic	NNS
cord-006702-ekf6mja9	486	3	were	be	VBD
cord-006702-ekf6mja9	486	4	similar	similar	JJ
cord-006702-ekf6mja9	486	5	in	in	IN
cord-006702-ekf6mja9	486	6	both	both	DT
cord-006702-ekf6mja9	486	7	groups	group	NNS
cord-006702-ekf6mja9	486	8	.	.	.
cord-006702-ekf6mja9	487	1	At	at	IN
cord-006702-ekf6mja9	487	2	12	12	CD
cord-006702-ekf6mja9	487	3	months	month	NNS
cord-006702-ekf6mja9	487	4	,	,	,
cord-006702-ekf6mja9	487	5	median	median	JJ
cord-006702-ekf6mja9	487	6	reduction	reduction	NN
cord-006702-ekf6mja9	487	7	in	in	IN
cord-006702-ekf6mja9	487	8	lipids	lipid	NNS
cord-006702-ekf6mja9	487	9	in	in	IN
cord-006702-ekf6mja9	487	10	atorvastatin	atorvastatin	NNP
cord-006702-ekf6mja9	487	11	versus	versus	IN
cord-006702-ekf6mja9	487	12	placebo	placebo	NN
cord-006702-ekf6mja9	487	13	was	be	VBD
cord-006702-ekf6mja9	487	14	similar	similar	JJ
cord-006702-ekf6mja9	487	15	in	in	IN
cord-006702-ekf6mja9	487	16	total	total	JJ
cord-006702-ekf6mja9	487	17	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	487	18	,	,	,
cord-006702-ekf6mja9	487	19	LDL	LDL	NNP
cord-006702-ekf6mja9	487	20	-	-	HYPH
cord-006702-ekf6mja9	487	21	C	C	NNP
cord-006702-ekf6mja9	487	22	,	,	,
cord-006702-ekf6mja9	487	23	triglyceride	triglyceride	NN
cord-006702-ekf6mja9	487	24	,	,	,
cord-006702-ekf6mja9	487	25	apolipoprotein	apolipoprotein	NN
cord-006702-ekf6mja9	487	26	A	a	NN
cord-006702-ekf6mja9	487	27	and	and	CC
cord-006702-ekf6mja9	487	28	high	high	JJ
cord-006702-ekf6mja9	487	29	density	density	NN
cord-006702-ekf6mja9	487	30	lipoprotein	lipoprotein	NN
cord-006702-ekf6mja9	487	31	(	(	-LRB-
cord-006702-ekf6mja9	487	32	P>0.5	P>0.5	NNP
cord-006702-ekf6mja9	487	33	;	;	:
cord-006702-ekf6mja9	487	34	Table	Table	NNP
cord-006702-ekf6mja9	487	35	1	1	CD
cord-006702-ekf6mja9	487	36	&	&	CC
cord-006702-ekf6mja9	487	37	Study	Study	NNP
cord-006702-ekf6mja9	487	38	flow	flow	NN
cord-006702-ekf6mja9	487	39	and	and	CC
cord-006702-ekf6mja9	487	40	outcome	outcome	NN
cord-006702-ekf6mja9	487	41	after	after	IN
cord-006702-ekf6mja9	487	42	12	12	CD
cord-006702-ekf6mja9	487	43	months	month	NNS
cord-006702-ekf6mja9	487	44	of	of	IN
cord-006702-ekf6mja9	487	45	administration	administration	NN
cord-006702-ekf6mja9	487	46	of	of	IN
cord-006702-ekf6mja9	487	47	atorvastatin	atorvastatin	NNP
cord-006702-ekf6mja9	487	48	Conclusions	Conclusions	NNPS
cord-006702-ekf6mja9	487	49	:	:	:
cord-006702-ekf6mja9	488	1	Therapy	therapy	NN
cord-006702-ekf6mja9	488	2	with	with	IN
cord-006702-ekf6mja9	488	3	atorvastatin	atorvastatin	NNP
cord-006702-ekf6mja9	488	4	(	(	-LRB-
cord-006702-ekf6mja9	488	5	10	10	CD
cord-006702-ekf6mja9	488	6	mg	mg	NNP
cord-006702-ekf6mja9	488	7	/	/	SYM
cord-006702-ekf6mja9	488	8	day	day	NN
cord-006702-ekf6mja9	488	9	)	)	-RRB-
cord-006702-ekf6mja9	488	10	for	for	IN
cord-006702-ekf6mja9	488	11	a	a	DT
cord-006702-ekf6mja9	488	12	year	year	NN
cord-006702-ekf6mja9	488	13	significantly	significantly	RB
cord-006702-ekf6mja9	488	14	reduced	reduce	VBN
cord-006702-ekf6mja9	488	15	apolipoprotein	apolipoprotein	NN
cord-006702-ekf6mja9	488	16	B	b	NN
cord-006702-ekf6mja9	488	17	levels	level	NNS
cord-006702-ekf6mja9	488	18	but	but	CC
cord-006702-ekf6mja9	488	19	was	be	VBD
cord-006702-ekf6mja9	488	20	ineffective	ineffective	JJ
cord-006702-ekf6mja9	488	21	in	in	IN
cord-006702-ekf6mja9	488	22	reducing	reduce	VBG
cord-006702-ekf6mja9	488	23	other	other	JJ
cord-006702-ekf6mja9	488	24	lipoproteins	lipoprotein	NNS
cord-006702-ekf6mja9	488	25	in	in	IN
cord-006702-ekf6mja9	488	26	children	child	NNS
cord-006702-ekf6mja9	488	27	with	with	IN
cord-006702-ekf6mja9	488	28	refractory	refractory	JJ
cord-006702-ekf6mja9	488	29	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	488	30	syndrome	syndrome	NN
cord-006702-ekf6mja9	488	31	;	;	:
cord-006702-ekf6mja9	488	32	there	there	EX
cord-006702-ekf6mja9	488	33	was	be	VBD
cord-006702-ekf6mja9	488	34	no	no	DT
cord-006702-ekf6mja9	488	35	beneficial	beneficial	JJ
cord-006702-ekf6mja9	488	36	effect	effect	NN
cord-006702-ekf6mja9	488	37	on	on	IN
cord-006702-ekf6mja9	488	38	cIMT	cimt	JJ
cord-006702-ekf6mja9	488	39	and	and	CC
cord-006702-ekf6mja9	488	40	brachial	brachial	JJ
cord-006702-ekf6mja9	488	41	artery	artery	NN
cord-006702-ekf6mja9	488	42	FMD	FMD	NNP
cord-006702-ekf6mja9	488	43	.	.	.
cord-006702-ekf6mja9	489	1	Serum	serum	NN
cord-006702-ekf6mja9	489	2	albumin	albumin	NN
cord-006702-ekf6mja9	489	3	was	be	VBD
cord-006702-ekf6mja9	489	4	a	a	DT
cord-006702-ekf6mja9	489	5	strong	strong	JJ
cord-006702-ekf6mja9	489	6	independent	independent	JJ
cord-006702-ekf6mja9	489	7	predictor	predictor	NN
cord-006702-ekf6mja9	489	8	of	of	IN
cord-006702-ekf6mja9	489	9	the	the	DT
cord-006702-ekf6mja9	489	10	lipid	lipid	NN
cord-006702-ekf6mja9	489	11	levels	level	NNS
cord-006702-ekf6mja9	489	12	in	in	IN
cord-006702-ekf6mja9	489	13	these	these	DT
cord-006702-ekf6mja9	489	14	children	child	NNS
cord-006702-ekf6mja9	489	15	.	.	.
cord-006702-ekf6mja9	490	1	FP	FP	NNP
cord-006702-ekf6mja9	490	2	-	-	HYPH
cord-006702-ekf6mja9	490	3	S15	S15	NNP
cord-006702-ekf6mja9	490	4	-	-	HYPH
cord-006702-ekf6mja9	490	5	2	2	CD
cord-006702-ekf6mja9	490	6	IL-6	IL-6	NNP
cord-006702-ekf6mja9	490	7	disruption	disruption	NN
cord-006702-ekf6mja9	490	8	improves	improve	VBZ
cord-006702-ekf6mja9	490	9	anemia	anemia	NN
cord-006702-ekf6mja9	490	10	but	but	CC
cord-006702-ekf6mja9	490	11	not	not	RB
cord-006702-ekf6mja9	490	12	growth	growth	NN
cord-006702-ekf6mja9	490	13	in	in	IN
cord-006702-ekf6mja9	490	14	developing	develop	VBG
cord-006702-ekf6mja9	490	15	mice	mouse	NNS
cord-006702-ekf6mja9	490	16	with	with	IN
cord-006702-ekf6mja9	490	17	CKD	CKD	NNP
cord-006702-ekf6mja9	490	18	V.	V.	NNP
cord-006702-ekf6mja9	490	19	Dalal	Dalal	NNP
cord-006702-ekf6mja9	490	20	(	(	-LRB-
cord-006702-ekf6mja9	490	21	1	1	CD
cord-006702-ekf6mja9	490	22	)	)	-RRB-
cord-006702-ekf6mja9	490	23	,	,	,
cord-006702-ekf6mja9	490	24	O.	O.	NNP
cord-006702-ekf6mja9	490	25	Akchurin	Akchurin	NNP
cord-006702-ekf6mja9	490	26	(	(	-LRB-
cord-006702-ekf6mja9	490	27	1	1	CD
cord-006702-ekf6mja9	490	28	)	)	-RRB-
cord-006702-ekf6mja9	490	29	,	,	,
cord-006702-ekf6mja9	490	30	A.	A.	NNP
cord-006702-ekf6mja9	490	31	Sureshbabu	Sureshbabu	NNP
cord-006702-ekf6mja9	490	32	(	(	-LRB-
cord-006702-ekf6mja9	490	33	1	1	CD
cord-006702-ekf6mja9	490	34	)	)	-RRB-
cord-006702-ekf6mja9	490	35	,	,	,
cord-006702-ekf6mja9	490	36	G.	G.	NNP
cord-006702-ekf6mja9	490	37	Kaur	Kaur	NNP
cord-006702-ekf6mja9	490	38	(	(	-LRB-
cord-006702-ekf6mja9	490	39	1	1	CD
cord-006702-ekf6mja9	490	40	)	)	-RRB-
cord-006702-ekf6mja9	490	41	,	,	,
cord-006702-ekf6mja9	490	42	S.	S.	NNP
cord-006702-ekf6mja9	490	43	Cunninghamrundles	Cunninghamrundles	NNP
cord-006702-ekf6mja9	490	44	(	(	-LRB-
cord-006702-ekf6mja9	490	45	1	1	CD
cord-006702-ekf6mja9	490	46	)	)	-RRB-
cord-006702-ekf6mja9	490	47	,	,	,
cord-006702-ekf6mja9	490	48	M.	M.	NNP
cord-006702-ekf6mja9	490	49	Choi	Choi	NNP
cord-006702-ekf6mja9	490	50	(	(	-LRB-
cord-006702-ekf6mja9	490	51	1	1	CD
cord-006702-ekf6mja9	490	52	)	)	-RRB-
cord-006702-ekf6mja9	490	53	,	,	,
cord-006702-ekf6mja9	490	54	S.	S.	NNP
cord-006702-ekf6mja9	490	55	Rivella	Rivella	NNP
cord-006702-ekf6mja9	490	56	(	(	-LRB-
cord-006702-ekf6mja9	490	57	2	2	CD
cord-006702-ekf6mja9	490	58	)	)	-RRB-
cord-006702-ekf6mja9	490	59	(	(	-LRB-
cord-006702-ekf6mja9	490	60	1	1	LS
cord-006702-ekf6mja9	490	61	)	)	-RRB-
cord-006702-ekf6mja9	490	62	Weill	Weill	NNP
cord-006702-ekf6mja9	490	63	Cornell	Cornell	NNP
cord-006702-ekf6mja9	490	64	Medical	Medical	NNP
cord-006702-ekf6mja9	490	65	College	College	NNP
cord-006702-ekf6mja9	490	66	,	,	,
cord-006702-ekf6mja9	490	67	New	New	NNP
cord-006702-ekf6mja9	490	68	York	York	NNP
cord-006702-ekf6mja9	490	69	,	,	,
cord-006702-ekf6mja9	490	70	United	United	NNP
cord-006702-ekf6mja9	490	71	States	States	NNP
cord-006702-ekf6mja9	490	72	;	;	:
cord-006702-ekf6mja9	490	73	(	(	-LRB-
cord-006702-ekf6mja9	490	74	2	2	LS
cord-006702-ekf6mja9	490	75	)	)	-RRB-
cord-006702-ekf6mja9	491	1	Children	child	NNS
cord-006702-ekf6mja9	491	2	's	's	POS
cord-006702-ekf6mja9	491	3	Hospital	Hospital	NNP
cord-006702-ekf6mja9	491	4	of	of	IN
cord-006702-ekf6mja9	491	5	Philadelphia	Philadelphia	NNP
cord-006702-ekf6mja9	491	6	,	,	,
cord-006702-ekf6mja9	491	7	Philadelphia	Philadelphia	NNP
cord-006702-ekf6mja9	491	8	,	,	,
cord-006702-ekf6mja9	491	9	United	United	NNP
cord-006702-ekf6mja9	491	10	States	States	NNP
cord-006702-ekf6mja9	491	11	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	491	12	:	:	:
cord-006702-ekf6mja9	491	13	Interleukin-6	Interleukin-6	.
cord-006702-ekf6mja9	492	1	(	(	-LRB-
cord-006702-ekf6mja9	492	2	IL-6	IL-6	NNP
cord-006702-ekf6mja9	492	3	)	)	-RRB-
cord-006702-ekf6mja9	492	4	,	,	,
cord-006702-ekf6mja9	492	5	a	a	DT
cord-006702-ekf6mja9	492	6	major	major	JJ
cord-006702-ekf6mja9	492	7	activator	activator	NN
cord-006702-ekf6mja9	492	8	of	of	IN
cord-006702-ekf6mja9	492	9	hepcidin	hepcidin	NNP
cord-006702-ekf6mja9	492	10	,	,	,
cord-006702-ekf6mja9	492	11	is	be	VBZ
cord-006702-ekf6mja9	492	12	elevated	elevate	VBN
cord-006702-ekf6mja9	492	13	in	in	IN
cord-006702-ekf6mja9	492	14	children	child	NNS
cord-006702-ekf6mja9	492	15	with	with	IN
cord-006702-ekf6mja9	492	16	advanced	advanced	JJ
cord-006702-ekf6mja9	492	17	CKD	CKD	NNP
cord-006702-ekf6mja9	492	18	and	and	CC
cord-006702-ekf6mja9	492	19	in	in	IN
cord-006702-ekf6mja9	492	20	the	the	DT
cord-006702-ekf6mja9	492	21	adenine	adenine	NN
cord-006702-ekf6mja9	492	22	-	-	HYPH
cord-006702-ekf6mja9	492	23	based	base	VBN
cord-006702-ekf6mja9	492	24	rodent	rodent	NN
cord-006702-ekf6mja9	492	25	model	model	NN
cord-006702-ekf6mja9	492	26	of	of	IN
cord-006702-ekf6mja9	492	27	CKD	CKD	NNP
cord-006702-ekf6mja9	492	28	.	.	.
cord-006702-ekf6mja9	493	1	Anti	Anti	NNP
cord-006702-ekf6mja9	493	2	-	-	JJ
cord-006702-ekf6mja9	493	3	IL-6	il-6	JJ
cord-006702-ekf6mja9	493	4	therapies	therapy	NNS
cord-006702-ekf6mja9	493	5	improve	improve	VBP
cord-006702-ekf6mja9	493	6	anemia	anemia	NN
cord-006702-ekf6mja9	493	7	in	in	IN
cord-006702-ekf6mja9	493	8	many	many	JJ
cord-006702-ekf6mja9	493	9	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	493	10	disorders	disorder	NNS
cord-006702-ekf6mja9	493	11	but	but	CC
cord-006702-ekf6mja9	493	12	it	-PRON-	PRP
cord-006702-ekf6mja9	493	13	is	be	VBZ
cord-006702-ekf6mja9	493	14	unknown	unknown	JJ
cord-006702-ekf6mja9	493	15	if	if	IN
cord-006702-ekf6mja9	493	16	IL-6	IL-6	NNP
cord-006702-ekf6mja9	493	17	blockade	blockade	NN
cord-006702-ekf6mja9	493	18	improves	improve	VBZ
cord-006702-ekf6mja9	493	19	anemia	anemia	NN
cord-006702-ekf6mja9	493	20	in	in	IN
cord-006702-ekf6mja9	493	21	juvenile	juvenile	JJ
cord-006702-ekf6mja9	493	22	CKD	CKD	NNP
cord-006702-ekf6mja9	493	23	.	.	.
cord-006702-ekf6mja9	494	1	Methods	method	NNS
cord-006702-ekf6mja9	494	2	:	:	:
cord-006702-ekf6mja9	494	3	CKD	CKD	NNP
cord-006702-ekf6mja9	494	4	was	be	VBD
cord-006702-ekf6mja9	494	5	induced	induce	VBN
cord-006702-ekf6mja9	494	6	by	by	IN
cord-006702-ekf6mja9	494	7	a	a	DT
cord-006702-ekf6mja9	494	8	0.2	0.2	CD
cord-006702-ekf6mja9	494	9	%	%	NN
cord-006702-ekf6mja9	494	10	adenine	adenine	NN
cord-006702-ekf6mja9	494	11	diet	diet	NN
cord-006702-ekf6mja9	494	12	given	give	VBN
cord-006702-ekf6mja9	494	13	for	for	IN
cord-006702-ekf6mja9	494	14	8	8	CD
cord-006702-ekf6mja9	494	15	weeks	week	NNS
cord-006702-ekf6mja9	494	16	to	to	IN
cord-006702-ekf6mja9	494	17	wild	wild	JJ
cord-006702-ekf6mja9	494	18	type	type	NN
cord-006702-ekf6mja9	494	19	(	(	-LRB-
cord-006702-ekf6mja9	494	20	WA	WA	NNP
cord-006702-ekf6mja9	494	21	)	)	-RRB-
cord-006702-ekf6mja9	494	22	and	and	CC
cord-006702-ekf6mja9	494	23	il6	il6	NNS
cord-006702-ekf6mja9	494	24	knockout	knockout	NN
cord-006702-ekf6mja9	494	25	(	(	-LRB-
cord-006702-ekf6mja9	494	26	IL6A	IL6A	''
cord-006702-ekf6mja9	494	27	)	)	-RRB-
cord-006702-ekf6mja9	495	1	male	male	JJ
cord-006702-ekf6mja9	495	2	mice	mouse	NNS
cord-006702-ekf6mja9	495	3	starting	start	VBG
cord-006702-ekf6mja9	495	4	at	at	IN
cord-006702-ekf6mja9	495	5	3	3	CD
cord-006702-ekf6mja9	495	6	weeks	week	NNS
cord-006702-ekf6mja9	495	7	of	of	IN
cord-006702-ekf6mja9	495	8	age	age	NN
cord-006702-ekf6mja9	495	9	.	.	.
cord-006702-ekf6mja9	496	1	Respective	respective	JJ
cord-006702-ekf6mja9	496	2	littermates	littermate	NNS
cord-006702-ekf6mja9	496	3	fed	feed	VBD
cord-006702-ekf6mja9	496	4	a	a	DT
cord-006702-ekf6mja9	496	5	regular	regular	JJ
cord-006702-ekf6mja9	496	6	diet	diet	NN
cord-006702-ekf6mja9	496	7	served	serve	VBD
cord-006702-ekf6mja9	496	8	as	as	IN
cord-006702-ekf6mja9	496	9	controls	control	NNS
cord-006702-ekf6mja9	496	10	(	(	-LRB-
cord-006702-ekf6mja9	496	11	WC	WC	NNP
cord-006702-ekf6mja9	496	12	and	and	CC
cord-006702-ekf6mja9	496	13	IL6C	IL6C	NNP
cord-006702-ekf6mja9	496	14	)	)	-RRB-
cord-006702-ekf6mja9	496	15	.	.	.
cord-006702-ekf6mja9	497	1	Blood	blood	NN
cord-006702-ekf6mja9	497	2	was	be	VBD
cord-006702-ekf6mja9	497	3	obtained	obtain	VBN
cord-006702-ekf6mja9	497	4	at	at	IN
cord-006702-ekf6mja9	497	5	sacrifice	sacrifice	NN
cord-006702-ekf6mja9	497	6	at	at	IN
cord-006702-ekf6mja9	497	7	11	11	CD
cord-006702-ekf6mja9	497	8	weeks	week	NNS
cord-006702-ekf6mja9	497	9	of	of	IN
cord-006702-ekf6mja9	497	10	age	age	NN
cord-006702-ekf6mja9	497	11	and	and	CC
cord-006702-ekf6mja9	497	12	nose	nose	NN
cord-006702-ekf6mja9	497	13	to	to	IN
cord-006702-ekf6mja9	497	14	tip	tip	NN
cord-006702-ekf6mja9	497	15	of	of	IN
cord-006702-ekf6mja9	497	16	tail	tail	NN
cord-006702-ekf6mja9	497	17	length	length	NN
cord-006702-ekf6mja9	497	18	was	be	VBD
cord-006702-ekf6mja9	497	19	measured	measure	VBN
cord-006702-ekf6mja9	497	20	to	to	TO
cord-006702-ekf6mja9	497	21	assess	assess	VB
cord-006702-ekf6mja9	497	22	linear	linear	JJ
cord-006702-ekf6mja9	497	23	growth	growth	NN
cord-006702-ekf6mja9	497	24	.	.	.
cord-006702-ekf6mja9	498	1	Results	result	NNS
cord-006702-ekf6mja9	498	2	:	:	:
cord-006702-ekf6mja9	499	1	WA	WA	NNP
cord-006702-ekf6mja9	499	2	and	and	CC
cord-006702-ekf6mja9	499	3	IL6A	il6a	CD
cord-006702-ekf6mja9	499	4	mice	mouse	NNS
cord-006702-ekf6mja9	499	5	showed	show	VBD
cord-006702-ekf6mja9	499	6	3-fold	3-fold	CD
cord-006702-ekf6mja9	499	7	elevated	elevated	JJ
cord-006702-ekf6mja9	499	8	BUN	bun	NN
cord-006702-ekf6mja9	499	9	,	,	,
cord-006702-ekf6mja9	499	10	serum	serum	NN
cord-006702-ekf6mja9	499	11	creatinine	creatinine	NN
cord-006702-ekf6mja9	499	12	and	and	CC
cord-006702-ekf6mja9	499	13	phosphorus	phosphorus	NN
cord-006702-ekf6mja9	499	14	,	,	,
cord-006702-ekf6mja9	499	15	as	as	IN
cord-006702-ekf6mja9	499	16	compared	compare	VBN
cord-006702-ekf6mja9	499	17	with	with	IN
cord-006702-ekf6mja9	499	18	WC	WC	NNP
cord-006702-ekf6mja9	499	19	and	and	CC
cord-006702-ekf6mja9	499	20	IL6C	il6c	PRP
cord-006702-ekf6mja9	499	21	,	,	,
cord-006702-ekf6mja9	499	22	respectively	respectively	RB
cord-006702-ekf6mja9	499	23	(	(	-LRB-
cord-006702-ekf6mja9	499	24	p<0.001	p<0.001	JJ
cord-006702-ekf6mja9	499	25	)	)	-RRB-
cord-006702-ekf6mja9	499	26	;	;	:
cord-006702-ekf6mja9	499	27	il6	il6	NNP
cord-006702-ekf6mja9	499	28	disruption	disruption	NN
cord-006702-ekf6mja9	499	29	did	do	VBD
cord-006702-ekf6mja9	499	30	not	not	RB
cord-006702-ekf6mja9	499	31	improve	improve	VB
cord-006702-ekf6mja9	499	32	these	these	DT
cord-006702-ekf6mja9	499	33	markers	marker	NNS
cord-006702-ekf6mja9	499	34	of	of	IN
cord-006702-ekf6mja9	499	35	CKD	CKD	NNP
cord-006702-ekf6mja9	499	36	.	.	.
cord-006702-ekf6mja9	500	1	All	all	DT
cord-006702-ekf6mja9	500	2	hematologic	hematologic	JJ
cord-006702-ekf6mja9	500	3	(	(	-LRB-
cord-006702-ekf6mja9	500	4	CBC	CBC	NNP
cord-006702-ekf6mja9	500	5	)	)	-RRB-
cord-006702-ekf6mja9	500	6	parameters	parameter	NNS
cord-006702-ekf6mja9	500	7	were	be	VBD
cord-006702-ekf6mja9	500	8	similar	similar	JJ
cord-006702-ekf6mja9	500	9	between	between	IN
cord-006702-ekf6mja9	500	10	WC	WC	NNP
cord-006702-ekf6mja9	500	11	and	and	CC
cord-006702-ekf6mja9	500	12	IL6C	IL6C	NNP
cord-006702-ekf6mja9	500	13	groups	group	NNS
cord-006702-ekf6mja9	500	14	.	.	.
cord-006702-ekf6mja9	501	1	Adenine	adenine	NN
cord-006702-ekf6mja9	501	2	-	-	HYPH
cord-006702-ekf6mja9	501	3	induced	induce	VBN
cord-006702-ekf6mja9	501	4	CKD	CKD	NNP
cord-006702-ekf6mja9	501	5	led	lead	VBD
cord-006702-ekf6mja9	501	6	to	to	IN
cord-006702-ekf6mja9	501	7	anemia	anemia	NN
cord-006702-ekf6mja9	501	8	in	in	IN
cord-006702-ekf6mja9	501	9	WA	WA	NNP
cord-006702-ekf6mja9	501	10	mice	mouse	NNS
cord-006702-ekf6mja9	501	11	,	,	,
cord-006702-ekf6mja9	501	12	as	as	IN
cord-006702-ekf6mja9	501	13	evidenced	evidence	VBN
cord-006702-ekf6mja9	501	14	by	by	IN
cord-006702-ekf6mja9	501	15	significantly	significantly	RB
cord-006702-ekf6mja9	501	16	decreased	decrease	VBN
cord-006702-ekf6mja9	501	17	hemoglobin	hemoglobin	NN
cord-006702-ekf6mja9	501	18	,	,	,
cord-006702-ekf6mja9	501	19	hematocrit	hematocrit	NN
cord-006702-ekf6mja9	501	20	,	,	,
cord-006702-ekf6mja9	501	21	and	and	CC
cord-006702-ekf6mja9	501	22	mean	mean	VB
cord-006702-ekf6mja9	501	23	corpuscular	corpuscular	JJ
cord-006702-ekf6mja9	501	24	volume	volume	NN
cord-006702-ekf6mja9	501	25	,	,	,
cord-006702-ekf6mja9	501	26	compared	compare	VBN
cord-006702-ekf6mja9	501	27	to	to	IN
cord-006702-ekf6mja9	501	28	WC	WC	NNP
cord-006702-ekf6mja9	501	29	mice	mouse	NNS
cord-006702-ekf6mja9	501	30	(	(	-LRB-
cord-006702-ekf6mja9	501	31	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	501	32	)	)	-RRB-
cord-006702-ekf6mja9	501	33	.	.	.
cord-006702-ekf6mja9	502	1	These	these	DT
cord-006702-ekf6mja9	502	2	erythroid	erythroid	NN
cord-006702-ekf6mja9	502	3	parameters	parameter	NNS
cord-006702-ekf6mja9	502	4	,	,	,
cord-006702-ekf6mja9	502	5	however	however	RB
cord-006702-ekf6mja9	502	6	,	,	,
cord-006702-ekf6mja9	502	7	were	be	VBD
cord-006702-ekf6mja9	502	8	similar	similar	JJ
cord-006702-ekf6mja9	502	9	between	between	IN
cord-006702-ekf6mja9	502	10	IL6A	IL6A	NNP
cord-006702-ekf6mja9	502	11	and	and	CC
cord-006702-ekf6mja9	502	12	IL6C	IL6C	NNP
cord-006702-ekf6mja9	502	13	groups	group	NNS
cord-006702-ekf6mja9	502	14	.	.	.
cord-006702-ekf6mja9	503	1	This	this	DT
cord-006702-ekf6mja9	503	2	was	be	VBD
cord-006702-ekf6mja9	503	3	likely	likely	RB
cord-006702-ekf6mja9	503	4	achieved	achieve	VBN
cord-006702-ekf6mja9	503	5	in	in	IN
cord-006702-ekf6mja9	503	6	part	part	NN
cord-006702-ekf6mja9	503	7	via	via	IN
cord-006702-ekf6mja9	503	8	activation	activation	NN
cord-006702-ekf6mja9	503	9	of	of	IN
cord-006702-ekf6mja9	503	10	erythropoiesis	erythropoiesis	NN
cord-006702-ekf6mja9	503	11	in	in	IN
cord-006702-ekf6mja9	503	12	IL-6A	IL-6A	NNP
cord-006702-ekf6mja9	503	13	group	group	NN
cord-006702-ekf6mja9	503	14	,	,	,
cord-006702-ekf6mja9	503	15	as	as	IN
cord-006702-ekf6mja9	503	16	indicated	indicate	VBN
cord-006702-ekf6mja9	503	17	by	by	IN
cord-006702-ekf6mja9	503	18	greater	great	JJR
cord-006702-ekf6mja9	503	19	reticulocytosis	reticulocytosis	NN
cord-006702-ekf6mja9	503	20	in	in	IN
cord-006702-ekf6mja9	503	21	the	the	DT
cord-006702-ekf6mja9	503	22	IL6A	IL6A	NNP
cord-006702-ekf6mja9	503	23	group	group	NN
cord-006702-ekf6mja9	503	24	as	as	IN
cord-006702-ekf6mja9	503	25	compared	compare	VBN
cord-006702-ekf6mja9	503	26	to	to	IN
cord-006702-ekf6mja9	503	27	WA	WA	NNP
cord-006702-ekf6mja9	503	28	group	group	NN
cord-006702-ekf6mja9	503	29	.	.	.
cord-006702-ekf6mja9	504	1	Body	body	NN
cord-006702-ekf6mja9	504	2	length	length	NN
cord-006702-ekf6mja9	504	3	,	,	,
cord-006702-ekf6mja9	504	4	weight	weight	NN
cord-006702-ekf6mja9	504	5	,	,	,
cord-006702-ekf6mja9	504	6	and	and	CC
cord-006702-ekf6mja9	504	7	body	body	NN
cord-006702-ekf6mja9	504	8	mass	mass	NN
cord-006702-ekf6mja9	504	9	index	index	NN
cord-006702-ekf6mja9	504	10	(	(	-LRB-
cord-006702-ekf6mja9	504	11	BMI	BMI	NNP
cord-006702-ekf6mja9	504	12	)	)	-RRB-
cord-006702-ekf6mja9	504	13	were	be	VBD
cord-006702-ekf6mja9	504	14	all	all	DT
cord-006702-ekf6mja9	504	15	significantly	significantly	RB
cord-006702-ekf6mja9	504	16	decreased	decrease	VBD
cord-006702-ekf6mja9	504	17	in	in	IN
cord-006702-ekf6mja9	504	18	WA	WA	NNP
cord-006702-ekf6mja9	504	19	vs.	vs.	IN
cord-006702-ekf6mja9	504	20	WC	WC	NNP
cord-006702-ekf6mja9	504	21	mice	mouse	NNS
cord-006702-ekf6mja9	504	22	and	and	CC
cord-006702-ekf6mja9	505	1	in	in	IN
cord-006702-ekf6mja9	505	2	IL-6A	IL-6A	NNP
cord-006702-ekf6mja9	505	3	vs.	vs.	IN
cord-006702-ekf6mja9	505	4	IL6-C	IL6-C	NNP
cord-006702-ekf6mja9	505	5	at	at	IN
cord-006702-ekf6mja9	505	6	the	the	DT
cord-006702-ekf6mja9	505	7	end	end	NN
cord-006702-ekf6mja9	505	8	of	of	IN
cord-006702-ekf6mja9	505	9	experimental	experimental	JJ
cord-006702-ekf6mja9	505	10	period	period	NN
cord-006702-ekf6mja9	505	11	(	(	-LRB-
cord-006702-ekf6mja9	505	12	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	505	13	)	)	-RRB-
cord-006702-ekf6mja9	505	14	.	.	.
cord-006702-ekf6mja9	506	1	There	there	EX
cord-006702-ekf6mja9	506	2	were	be	VBD
cord-006702-ekf6mja9	506	3	no	no	DT
cord-006702-ekf6mja9	506	4	significant	significant	JJ
cord-006702-ekf6mja9	506	5	differences	difference	NNS
cord-006702-ekf6mja9	506	6	in	in	IN
cord-006702-ekf6mja9	506	7	these	these	DT
cord-006702-ekf6mja9	506	8	measurements	measurement	NNS
cord-006702-ekf6mja9	506	9	between	between	IN
cord-006702-ekf6mja9	506	10	the	the	DT
cord-006702-ekf6mja9	506	11	WC	WC	NNP
cord-006702-ekf6mja9	506	12	and	and	CC
cord-006702-ekf6mja9	506	13	IL-6C	IL-6C	NNP
cord-006702-ekf6mja9	506	14	,	,	,
cord-006702-ekf6mja9	506	15	nor	nor	CC
cord-006702-ekf6mja9	506	16	between	between	IN
cord-006702-ekf6mja9	506	17	the	the	DT
cord-006702-ekf6mja9	506	18	WA	WA	NNP
cord-006702-ekf6mja9	506	19	and	and	CC
cord-006702-ekf6mja9	506	20	IL-6A	IL-6A	NNP
cord-006702-ekf6mja9	506	21	groups	group	NNS
cord-006702-ekf6mja9	506	22	.	.	.
cord-006702-ekf6mja9	507	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	507	2	:	:	:
cord-006702-ekf6mja9	508	1	il6	il6	NNP
cord-006702-ekf6mja9	508	2	disruption	disruption	NN
cord-006702-ekf6mja9	508	3	rescued	rescue	VBD
cord-006702-ekf6mja9	508	4	the	the	DT
cord-006702-ekf6mja9	508	5	anemia	anemia	NN
cord-006702-ekf6mja9	508	6	phenotype	phenotype	NN
cord-006702-ekf6mja9	508	7	in	in	IN
cord-006702-ekf6mja9	508	8	developing	develop	VBG
cord-006702-ekf6mja9	508	9	male	male	JJ
cord-006702-ekf6mja9	508	10	mice	mouse	NNS
cord-006702-ekf6mja9	508	11	with	with	IN
cord-006702-ekf6mja9	508	12	adenine	adenine	NN
cord-006702-ekf6mja9	508	13	induced	induce	VBN
cord-006702-ekf6mja9	508	14	CKD	CKD	NNP
cord-006702-ekf6mja9	508	15	,	,	,
cord-006702-ekf6mja9	508	16	thus	thus	RB
cord-006702-ekf6mja9	508	17	suggesting	suggest	VBG
cord-006702-ekf6mja9	508	18	that	that	IN
cord-006702-ekf6mja9	508	19	the	the	DT
cord-006702-ekf6mja9	508	20	efficacy	efficacy	NN
cord-006702-ekf6mja9	508	21	of	of	IN
cord-006702-ekf6mja9	508	22	anti	anti	JJ
cord-006702-ekf6mja9	508	23	-	-	JJ
cord-006702-ekf6mja9	508	24	IL-6	il-6	JJ
cord-006702-ekf6mja9	508	25	therapies	therapy	NNS
cord-006702-ekf6mja9	508	26	in	in	IN
cord-006702-ekf6mja9	508	27	anemia	anemia	NN
cord-006702-ekf6mja9	508	28	control	control	NN
cord-006702-ekf6mja9	508	29	should	should	MD
cord-006702-ekf6mja9	508	30	be	be	VB
cord-006702-ekf6mja9	508	31	tested	test	VBN
cord-006702-ekf6mja9	508	32	in	in	IN
cord-006702-ekf6mja9	508	33	juvenile	juvenile	JJ
cord-006702-ekf6mja9	508	34	/	/	SYM
cord-006702-ekf6mja9	508	35	pediatric	pediatric	JJ
cord-006702-ekf6mja9	508	36	CKD	CKD	NNP
cord-006702-ekf6mja9	508	37	.	.	.
cord-006702-ekf6mja9	509	1	The	the	DT
cord-006702-ekf6mja9	509	2	mechanism	mechanism	NN
cord-006702-ekf6mja9	509	3	likely	likely	RB
cord-006702-ekf6mja9	509	4	involves	involve	VBZ
cord-006702-ekf6mja9	509	5	suppression	suppression	NN
cord-006702-ekf6mja9	509	6	of	of	IN
cord-006702-ekf6mja9	509	7	hepcidin	hepcidin	NNP
cord-006702-ekf6mja9	509	8	,	,	,
cord-006702-ekf6mja9	509	9	which	which	WDT
cord-006702-ekf6mja9	509	10	is	be	VBZ
cord-006702-ekf6mja9	509	11	being	be	VBG
cord-006702-ekf6mja9	509	12	validated	validate	VBN
cord-006702-ekf6mja9	509	13	in	in	IN
cord-006702-ekf6mja9	509	14	our	-PRON-	PRP$
cord-006702-ekf6mja9	509	15	ongoing	ongoing	JJ
cord-006702-ekf6mja9	509	16	experiments	experiment	NNS
cord-006702-ekf6mja9	509	17	.	.	.
cord-006702-ekf6mja9	510	1	In	in	IN
cord-006702-ekf6mja9	510	2	contrary	contrary	JJ
cord-006702-ekf6mja9	510	3	to	to	IN
cord-006702-ekf6mja9	510	4	other	other	JJ
cord-006702-ekf6mja9	510	5	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	510	6	conditions	condition	NNS
cord-006702-ekf6mja9	510	7	,	,	,
cord-006702-ekf6mja9	510	8	il6	il6	NNS
cord-006702-ekf6mja9	510	9	disruption	disruption	NN
cord-006702-ekf6mja9	510	10	did	do	VBD
cord-006702-ekf6mja9	510	11	not	not	RB
cord-006702-ekf6mja9	510	12	improve	improve	VB
cord-006702-ekf6mja9	510	13	linear	linear	JJ
cord-006702-ekf6mja9	510	14	growth	growth	NN
cord-006702-ekf6mja9	510	15	in	in	IN
cord-006702-ekf6mja9	510	16	this	this	DT
cord-006702-ekf6mja9	510	17	model	model	NN
cord-006702-ekf6mja9	510	18	.	.	.
cord-006702-ekf6mja9	511	1	FP	FP	NNP
cord-006702-ekf6mja9	511	2	-	-	HYPH
cord-006702-ekf6mja9	511	3	S15	S15	NNP
cord-006702-ekf6mja9	511	4	-	-	HYPH
cord-006702-ekf6mja9	511	5	3	3	CD
cord-006702-ekf6mja9	512	1	Erythropoietin	erythropoietin	NN
cord-006702-ekf6mja9	512	2	pathway	pathway	NN
cord-006702-ekf6mja9	512	3	dysregulation	dysregulation	NN
cord-006702-ekf6mja9	512	4	in	in	IN
cord-006702-ekf6mja9	512	5	anemia	anemia	NN
cord-006702-ekf6mja9	512	6	of	of	IN
cord-006702-ekf6mja9	512	7	chronic	chronic	JJ
cord-006702-ekf6mja9	512	8	kidney	kidney	NN
cord-006702-ekf6mja9	512	9	disease	disease	NN
cord-006702-ekf6mja9	512	10	D.	D.	NNP
cord-006702-ekf6mja9	512	11	Landau	Landau	NNP
cord-006702-ekf6mja9	512	12	(	(	-LRB-
cord-006702-ekf6mja9	512	13	1	1	CD
cord-006702-ekf6mja9	512	14	)	)	-RRB-
cord-006702-ekf6mja9	512	15	,	,	,
cord-006702-ekf6mja9	512	16	L.	L.	NNP
cord-006702-ekf6mja9	512	17	London	London	NNP
cord-006702-ekf6mja9	512	18	(	(	-LRB-
cord-006702-ekf6mja9	512	19	2	2	CD
cord-006702-ekf6mja9	512	20	)	)	-RRB-
cord-006702-ekf6mja9	512	21	,	,	,
cord-006702-ekf6mja9	512	22	Y.	Y.	NNP
cord-006702-ekf6mja9	512	23	Segev	Segev	NNP
cord-006702-ekf6mja9	512	24	(	(	-LRB-
cord-006702-ekf6mja9	512	25	2	2	CD
cord-006702-ekf6mja9	512	26	)	)	-RRB-
cord-006702-ekf6mja9	512	27	(	(	-LRB-
cord-006702-ekf6mja9	512	28	1	1	LS
cord-006702-ekf6mja9	512	29	)	)	-RRB-
cord-006702-ekf6mja9	512	30	Schneider	Schneider	NNP
cord-006702-ekf6mja9	512	31	Children	Children	NNP
cord-006702-ekf6mja9	512	32	's	's	POS
cord-006702-ekf6mja9	512	33	Medical	Medical	NNP
cord-006702-ekf6mja9	512	34	Center	Center	NNP
cord-006702-ekf6mja9	512	35	of	of	IN
cord-006702-ekf6mja9	512	36	Israel	Israel	NNP
cord-006702-ekf6mja9	512	37	,	,	,
cord-006702-ekf6mja9	512	38	Petach	Petach	NNP
cord-006702-ekf6mja9	512	39	Tikva	Tikva	NNP
cord-006702-ekf6mja9	512	40	,	,	,
cord-006702-ekf6mja9	512	41	Israel	Israel	NNP
cord-006702-ekf6mja9	512	42	;	;	:
cord-006702-ekf6mja9	512	43	(	(	-LRB-
cord-006702-ekf6mja9	512	44	2	2	LS
cord-006702-ekf6mja9	512	45	)	)	-RRB-
cord-006702-ekf6mja9	513	1	Ben	Ben	NNP
cord-006702-ekf6mja9	513	2	Gurion	Gurion	NNP
cord-006702-ekf6mja9	513	3	University	University	NNP
cord-006702-ekf6mja9	513	4	,	,	,
cord-006702-ekf6mja9	513	5	Beer	Beer	NNP
cord-006702-ekf6mja9	513	6	Sheva	Sheva	NNP
cord-006702-ekf6mja9	513	7	,	,	,
cord-006702-ekf6mja9	514	1	Israel	Israel	NNP
cord-006702-ekf6mja9	514	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	514	3	:	:	:
cord-006702-ekf6mja9	515	1	Anemia	anemia	NN
cord-006702-ekf6mja9	515	2	is	be	VBZ
cord-006702-ekf6mja9	515	3	a	a	DT
cord-006702-ekf6mja9	515	4	known	know	VBN
cord-006702-ekf6mja9	515	5	driver	driver	NN
cord-006702-ekf6mja9	515	6	for	for	IN
cord-006702-ekf6mja9	515	7	hypoxia	hypoxia	NN
cord-006702-ekf6mja9	515	8	inducible	inducible	JJ
cord-006702-ekf6mja9	515	9	factor	factor	NN
cord-006702-ekf6mja9	515	10	(	(	-LRB-
cord-006702-ekf6mja9	515	11	HIF	HIF	NNP
cord-006702-ekf6mja9	515	12	)	)	-RRB-
cord-006702-ekf6mja9	515	13	which	which	WDT
cord-006702-ekf6mja9	515	14	leads	lead	VBZ
cord-006702-ekf6mja9	515	15	to	to	IN
cord-006702-ekf6mja9	515	16	increased	increase	VBN
cord-006702-ekf6mja9	515	17	renal	renal	JJ
cord-006702-ekf6mja9	515	18	erythropoetin	erythropoetin	NNP
cord-006702-ekf6mja9	515	19	(	(	-LRB-
cord-006702-ekf6mja9	515	20	EPO	EPO	NNP
cord-006702-ekf6mja9	515	21	)	)	-RRB-
cord-006702-ekf6mja9	515	22	synthesis	synthesis	NN
cord-006702-ekf6mja9	515	23	,	,	,
cord-006702-ekf6mja9	515	24	resulting	result	VBG
cord-006702-ekf6mja9	515	25	in	in	IN
cord-006702-ekf6mja9	515	26	inhibited	inhibited	JJ
cord-006702-ekf6mja9	515	27	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	515	28	of	of	IN
cord-006702-ekf6mja9	515	29	bone	bone	NN
cord-006702-ekf6mja9	515	30	marrow	marrow	NN
cord-006702-ekf6mja9	515	31	(	(	-LRB-
cord-006702-ekf6mja9	515	32	BM	BM	NNP
cord-006702-ekf6mja9	515	33	)	)	-RRB-
cord-006702-ekf6mja9	515	34	erythroid	erythroid	JJ
cord-006702-ekf6mja9	515	35	precursosrs	precursosrs	NN
cord-006702-ekf6mja9	515	36	,	,	,
cord-006702-ekf6mja9	515	37	increasing	increase	VBG
cord-006702-ekf6mja9	515	38	back	back	JJ
cord-006702-ekf6mja9	515	39	red	red	JJ
cord-006702-ekf6mja9	515	40	cell	cell	NN
cord-006702-ekf6mja9	515	41	mass	mass	NN
cord-006702-ekf6mja9	515	42	.	.	.
cord-006702-ekf6mja9	516	1	Anemia	anemia	NN
cord-006702-ekf6mja9	516	2	of	of	IN
cord-006702-ekf6mja9	516	3	CKD	CKD	NNP
cord-006702-ekf6mja9	516	4	is	be	VBZ
cord-006702-ekf6mja9	516	5	due	due	JJ
cord-006702-ekf6mja9	516	6	to	to	IN
cord-006702-ekf6mja9	516	7	numerous	numerous	JJ
cord-006702-ekf6mja9	516	8	factors	factor	NNS
cord-006702-ekf6mja9	516	9	,	,	,
cord-006702-ekf6mja9	516	10	including	include	VBG
cord-006702-ekf6mja9	516	11	impaired	impaired	JJ
cord-006702-ekf6mja9	516	12	renal	renal	JJ
cord-006702-ekf6mja9	516	13	EPO	EPO	NNP
cord-006702-ekf6mja9	516	14	synthesis	synthesis	NN
cord-006702-ekf6mja9	516	15	and	and	CC
cord-006702-ekf6mja9	516	16	intestinal	intestinal	JJ
cord-006702-ekf6mja9	516	17	iron	iron	NN
cord-006702-ekf6mja9	516	18	absorption	absorption	NN
cord-006702-ekf6mja9	516	19	.	.	.
cord-006702-ekf6mja9	517	1	EPO	EPO	NNP
cord-006702-ekf6mja9	517	2	resistance	resistance	NN
cord-006702-ekf6mja9	517	3	in	in	IN
cord-006702-ekf6mja9	517	4	CKD	CKD	NNP
cord-006702-ekf6mja9	517	5	is	be	VBZ
cord-006702-ekf6mja9	517	6	a	a	DT
cord-006702-ekf6mja9	517	7	known	know	VBN
cord-006702-ekf6mja9	517	8	clinical	clinical	JJ
cord-006702-ekf6mja9	517	9	problem	problem	NN
cord-006702-ekf6mja9	517	10	,	,	,
cord-006702-ekf6mja9	517	11	but	but	CC
cord-006702-ekf6mja9	517	12	its	-PRON-	PRP$
cord-006702-ekf6mja9	517	13	mechanisms	mechanism	NNS
cord-006702-ekf6mja9	517	14	are	be	VBP
cord-006702-ekf6mja9	517	15	poorly	poorly	RB
cord-006702-ekf6mja9	517	16	understood	understand	VBN
cord-006702-ekf6mja9	517	17	.	.	.
cord-006702-ekf6mja9	518	1	EPO	EPO	NNP
cord-006702-ekf6mja9	518	2	receptor	receptor	NN
cord-006702-ekf6mja9	518	3	(	(	-LRB-
cord-006702-ekf6mja9	518	4	EPOR	EPOR	NNP
cord-006702-ekf6mja9	518	5	)	)	-RRB-
cord-006702-ekf6mja9	518	6	signals	signal	NNS
cord-006702-ekf6mja9	518	7	are	be	VBP
cord-006702-ekf6mja9	518	8	transduced	transduce	VBN
cord-006702-ekf6mja9	518	9	through	through	IN
cord-006702-ekf6mja9	518	10	a	a	DT
cord-006702-ekf6mja9	518	11	JAK2-STAT5	JAK2-STAT5	NNP
cord-006702-ekf6mja9	518	12	pathway	pathway	NN
cord-006702-ekf6mja9	518	13	.	.	.
cord-006702-ekf6mja9	519	1	Here	here	RB
cord-006702-ekf6mja9	519	2	we	-PRON-	PRP
cord-006702-ekf6mja9	519	3	investigated	investigate	VBD
cord-006702-ekf6mja9	519	4	the	the	DT
cord-006702-ekf6mja9	519	5	HIF	HIF	NNP
cord-006702-ekf6mja9	519	6	-	-	HYPH
cord-006702-ekf6mja9	519	7	EPO	EPO	NNP
cord-006702-ekf6mja9	519	8	-	-	HYPH
cord-006702-ekf6mja9	519	9	EPOR	EPOR	NNP
cord-006702-ekf6mja9	519	10	axis	axis	NN
cord-006702-ekf6mja9	519	11	in	in	IN
cord-006702-ekf6mja9	519	12	kidney	kidney	NN
cord-006702-ekf6mja9	519	13	,	,	,
cord-006702-ekf6mja9	519	14	BM	BM	NNP
cord-006702-ekf6mja9	519	15	and	and	CC
cord-006702-ekf6mja9	519	16	proximal	proximal	JJ
cord-006702-ekf6mja9	519	17	tibia	tibia	NN
cord-006702-ekf6mja9	519	18	/	/	SYM
cord-006702-ekf6mja9	519	19	epiphyseal	epiphyseal	JJ
cord-006702-ekf6mja9	519	20	growth	growth	NN
cord-006702-ekf6mja9	519	21	plate	plate	NN
cord-006702-ekf6mja9	519	22	(	(	-LRB-
cord-006702-ekf6mja9	519	23	EGP	EGP	NNP
cord-006702-ekf6mja9	519	24	)	)	-RRB-
cord-006702-ekf6mja9	519	25	in	in	IN
cord-006702-ekf6mja9	519	26	anemic	anemic	JJ
cord-006702-ekf6mja9	519	27	juvenile	juvenile	JJ
cord-006702-ekf6mja9	519	28	CKD	CKD	NNP
cord-006702-ekf6mja9	519	29	rats	rat	NNS
cord-006702-ekf6mja9	519	30	.	.	.
cord-006702-ekf6mja9	520	1	Methods	method	NNS
cord-006702-ekf6mja9	520	2	:	:	:
cord-006702-ekf6mja9	520	3	CKD	CKD	NNP
cord-006702-ekf6mja9	520	4	was	be	VBD
cord-006702-ekf6mja9	520	5	induced	induce	VBN
cord-006702-ekf6mja9	520	6	by	by	IN
cord-006702-ekf6mja9	520	7	5/6	5/6	CD
cord-006702-ekf6mja9	520	8	nephrectomy	nephrectomy	NN
cord-006702-ekf6mja9	520	9	in	in	IN
cord-006702-ekf6mja9	520	10	young	young	JJ
cord-006702-ekf6mja9	520	11	(	(	-LRB-
cord-006702-ekf6mja9	520	12	20	20	CD
cord-006702-ekf6mja9	520	13	d	d	NN
cord-006702-ekf6mja9	520	14	old	old	JJ
cord-006702-ekf6mja9	520	15	)	)	-RRB-
cord-006702-ekf6mja9	520	16	SD	sd	NN
cord-006702-ekf6mja9	520	17	rats	rat	NNS
cord-006702-ekf6mja9	520	18	while	while	IN
cord-006702-ekf6mja9	520	19	C	C	NNP
cord-006702-ekf6mja9	520	20	group	group	NN
cord-006702-ekf6mja9	520	21	was	be	VBD
cord-006702-ekf6mja9	520	22	sham	sham	NN
cord-006702-ekf6mja9	520	23	operated	operate	VBN
cord-006702-ekf6mja9	520	24	.	.	.
cord-006702-ekf6mja9	521	1	An	an	DT
cord-006702-ekf6mja9	521	2	additional	additional	JJ
cord-006702-ekf6mja9	521	3	control	control	NN
cord-006702-ekf6mja9	521	4	group	group	NN
cord-006702-ekf6mja9	521	5	was	be	VBD
cord-006702-ekf6mja9	521	6	daily	daily	RB
cord-006702-ekf6mja9	521	7	bled	bleed	VBN
cord-006702-ekf6mja9	521	8	for	for	IN
cord-006702-ekf6mja9	521	9	7	7	CD
cord-006702-ekf6mja9	521	10	days	day	NNS
cord-006702-ekf6mja9	521	11	to	to	TO
cord-006702-ekf6mja9	521	12	induce	induce	VB
cord-006702-ekf6mja9	521	13	iron	iron	NN
cord-006702-ekf6mja9	521	14	deficiency	deficiency	NN
cord-006702-ekf6mja9	521	15	anemia	anemia	NN
cord-006702-ekf6mja9	521	16	(	(	-LRB-
cord-006702-ekf6mja9	521	17	C	C	NNP
cord-006702-ekf6mja9	521	18	-	-	HYPH
cord-006702-ekf6mja9	521	19	A	A	NNP
cord-006702-ekf6mja9	521	20	)	)	-RRB-
cord-006702-ekf6mja9	521	21	.	.	.
cord-006702-ekf6mja9	522	1	Rats	rat	NNS
cord-006702-ekf6mja9	522	2	were	be	VBD
cord-006702-ekf6mja9	522	3	sacrificed	sacrifice	VBN
cord-006702-ekf6mja9	522	4	after	after	IN
cord-006702-ekf6mja9	522	5	4	4	CD
cord-006702-ekf6mja9	522	6	weeks	week	NNS
cord-006702-ekf6mja9	522	7	of	of	IN
cord-006702-ekf6mja9	522	8	CKD	CKD	NNP
cord-006702-ekf6mja9	522	9	.	.	.
cord-006702-ekf6mja9	523	1	A	a	DT
cord-006702-ekf6mja9	523	2	single	single	JJ
cord-006702-ekf6mja9	523	3	bolus	bolus	NN
cord-006702-ekf6mja9	523	4	of	of	IN
cord-006702-ekf6mja9	523	5	IV	IV	NNP
cord-006702-ekf6mja9	523	6	rhEPO	rhEPO	.
cord-006702-ekf6mja9	524	1	(	(	-LRB-
cord-006702-ekf6mja9	524	2	25	25	CD
cord-006702-ekf6mja9	524	3	U	U	NNP
cord-006702-ekf6mja9	524	4	/	/	SYM
cord-006702-ekf6mja9	524	5	kg	kg	NNP
cord-006702-ekf6mja9	524	6	)	)	-RRB-
cord-006702-ekf6mja9	524	7	was	be	VBD
cord-006702-ekf6mja9	524	8	provided	provide	VBN
cord-006702-ekf6mja9	524	9	5	5	CD
cord-006702-ekf6mja9	524	10	minutes	minute	NNS
cord-006702-ekf6mja9	524	11	prior	prior	RB
cord-006702-ekf6mja9	524	12	to	to	IN
cord-006702-ekf6mja9	524	13	sacrifice	sacrifice	NN
cord-006702-ekf6mja9	524	14	.	.	.
cord-006702-ekf6mja9	525	1	Results	result	NNS
cord-006702-ekf6mja9	525	2	:	:	:
cord-006702-ekf6mja9	526	1	Hemoglobin	hemoglobin	NN
cord-006702-ekf6mja9	526	2	levels	level	NNS
cord-006702-ekf6mja9	526	3	were	be	VBD
cord-006702-ekf6mja9	526	4	similarly	similarly	RB
cord-006702-ekf6mja9	526	5	reduced	reduce	VBN
cord-006702-ekf6mja9	526	6	in	in	IN
cord-006702-ekf6mja9	526	7	CKD	CKD	NNP
cord-006702-ekf6mja9	526	8	and	and	CC
cord-006702-ekf6mja9	526	9	C	C	NNP
cord-006702-ekf6mja9	526	10	-	-	HYPH
cord-006702-ekf6mja9	526	11	A	A	NNP
cord-006702-ekf6mja9	526	12	(	(	-LRB-
cord-006702-ekf6mja9	526	13	11.7+/-0.4	11.7+/-0.4	CD
cord-006702-ekf6mja9	526	14	AND	and	CC
cord-006702-ekf6mja9	526	15	10.8+/-0.2	10.8+/-0.2	CD
cord-006702-ekf6mja9	526	16	vs	vs	IN
cord-006702-ekf6mja9	526	17	14.3+/-0.2	14.3+/-0.2	CD
cord-006702-ekf6mja9	526	18	g	g	NNP
cord-006702-ekf6mja9	526	19	/	/	SYM
cord-006702-ekf6mja9	526	20	dL	dl	NN
cord-006702-ekf6mja9	526	21	,	,	,
cord-006702-ekf6mja9	526	22	p<0.001	p<0.001	CD
cord-006702-ekf6mja9	526	23	)	)	-RRB-
cord-006702-ekf6mja9	526	24	.	.	.
cord-006702-ekf6mja9	527	1	Serum	serum	NN
cord-006702-ekf6mja9	527	2	iron	iron	NN
cord-006702-ekf6mja9	527	3	and	and	CC
cord-006702-ekf6mja9	527	4	transferrin	transferrin	NN
cord-006702-ekf6mja9	527	5	levels	level	NNS
cord-006702-ekf6mja9	527	6	were	be	VBD
cord-006702-ekf6mja9	527	7	unchanged	unchanged	JJ
cord-006702-ekf6mja9	527	8	in	in	IN
cord-006702-ekf6mja9	527	9	CKD	CKD	NNP
cord-006702-ekf6mja9	527	10	.	.	.
cord-006702-ekf6mja9	528	1	Kidney	kidney	NN
cord-006702-ekf6mja9	528	2	HIF2a	HIF2a	NNP
cord-006702-ekf6mja9	528	3	was	be	VBD
cord-006702-ekf6mja9	528	4	elevated	elevate	VBN
cord-006702-ekf6mja9	528	5	in	in	IN
cord-006702-ekf6mja9	528	6	C	C	NNP
cord-006702-ekf6mja9	528	7	-	-	HYPH
cord-006702-ekf6mja9	528	8	A	a	NN
cord-006702-ekf6mja9	528	9	but	but	CC
cord-006702-ekf6mja9	528	10	unchanged	unchanged	JJ
cord-006702-ekf6mja9	528	11	in	in	IN
cord-006702-ekf6mja9	528	12	CKD	CKD	NNP
cord-006702-ekf6mja9	528	13	.	.	.
cord-006702-ekf6mja9	529	1	Remnant	remnant	JJ
cord-006702-ekf6mja9	529	2	kidney	kidney	NN
cord-006702-ekf6mja9	529	3	EPO	EPO	NNP
cord-006702-ekf6mja9	529	4	protein	protein	NN
cord-006702-ekf6mja9	529	5	and	and	CC
cord-006702-ekf6mja9	529	6	mRNA	mrna	NN
cord-006702-ekf6mja9	529	7	levels	level	NNS
cord-006702-ekf6mja9	529	8	were	be	VBD
cord-006702-ekf6mja9	529	9	unchanged	unchanged	JJ
cord-006702-ekf6mja9	529	10	in	in	IN
cord-006702-ekf6mja9	529	11	both	both	DT
cord-006702-ekf6mja9	529	12	C	C	NNP
cord-006702-ekf6mja9	529	13	-	-	HYPH
cord-006702-ekf6mja9	529	14	A	A	NNP
cord-006702-ekf6mja9	529	15	and	and	CC
cord-006702-ekf6mja9	529	16	CKD	CKD	NNP
cord-006702-ekf6mja9	529	17	.	.	.
cord-006702-ekf6mja9	530	1	BM	BM	NNP
cord-006702-ekf6mja9	530	2	EPO	EPO	NNP
cord-006702-ekf6mja9	530	3	protein	protein	NN
cord-006702-ekf6mja9	530	4	(	(	-LRB-
cord-006702-ekf6mja9	530	5	which	which	WDT
cord-006702-ekf6mja9	530	6	reflects	reflect	VBZ
cord-006702-ekf6mja9	530	7	circulating	circulate	VBG
cord-006702-ekf6mja9	530	8	EPO	EPO	NNP
cord-006702-ekf6mja9	530	9	)	)	-RRB-
cord-006702-ekf6mja9	530	10	was	be	VBD
cord-006702-ekf6mja9	530	11	increased	increase	VBN
cord-006702-ekf6mja9	530	12	in	in	IN
cord-006702-ekf6mja9	530	13	C	C	NNP
cord-006702-ekf6mja9	530	14	-	-	HYPH
cord-006702-ekf6mja9	530	15	A	a	NN
cord-006702-ekf6mja9	530	16	but	but	CC
cord-006702-ekf6mja9	530	17	unchanged	unchanged	JJ
cord-006702-ekf6mja9	530	18	in	in	IN
cord-006702-ekf6mja9	530	19	CKD	CKD	NNP
cord-006702-ekf6mja9	530	20	.	.	.
cord-006702-ekf6mja9	531	1	BM	BM	NNP
cord-006702-ekf6mja9	531	2	and	and	CC
cord-006702-ekf6mja9	531	3	EGP	EGP	NNP
cord-006702-ekf6mja9	531	4	EPOR	EPOR	NNP
cord-006702-ekf6mja9	531	5	were	be	VBD
cord-006702-ekf6mja9	531	6	unchanged	unchanged	JJ
cord-006702-ekf6mja9	531	7	in	in	IN
cord-006702-ekf6mja9	531	8	C	C	NNP
cord-006702-ekf6mja9	531	9	-	-	HYPH
cord-006702-ekf6mja9	531	10	A	a	NN
cord-006702-ekf6mja9	531	11	but	but	CC
cord-006702-ekf6mja9	531	12	decreased	decrease	VBD
cord-006702-ekf6mja9	531	13	in	in	IN
cord-006702-ekf6mja9	531	14	CKD	CKD	NNP
cord-006702-ekf6mja9	531	15	.	.	.
cord-006702-ekf6mja9	532	1	EGP	EGP	NNP
cord-006702-ekf6mja9	532	2	phospho	phospho	NNP
cord-006702-ekf6mja9	532	3	-	-	HYPH
cord-006702-ekf6mja9	532	4	STAT5	STAT5	NNP
cord-006702-ekf6mja9	532	5	was	be	VBD
cord-006702-ekf6mja9	532	6	significantly	significantly	RB
cord-006702-ekf6mja9	532	7	increased	increase	VBN
cord-006702-ekf6mja9	532	8	in	in	IN
cord-006702-ekf6mja9	532	9	C	c	NN
cord-006702-ekf6mja9	532	10	but	but	CC
cord-006702-ekf6mja9	532	11	unchanged	unchanged	JJ
cord-006702-ekf6mja9	532	12	in	in	IN
cord-006702-ekf6mja9	532	13	CKD	CKD	NNP
cord-006702-ekf6mja9	532	14	.	.	.
cord-006702-ekf6mja9	533	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	533	2	:	:	:
cord-006702-ekf6mja9	534	1	Anemia	anemia	NN
cord-006702-ekf6mja9	534	2	in	in	IN
cord-006702-ekf6mja9	534	3	young	young	JJ
cord-006702-ekf6mja9	534	4	CKD	CKD	NNP
cord-006702-ekf6mja9	534	5	rats	rat	NNS
cord-006702-ekf6mja9	534	6	is	be	VBZ
cord-006702-ekf6mja9	534	7	associated	associate	VBN
cord-006702-ekf6mja9	534	8	with	with	IN
cord-006702-ekf6mja9	534	9	a	a	DT
cord-006702-ekf6mja9	534	10	multilevel	multilevel	JJ
cord-006702-ekf6mja9	534	11	inappropriate	inappropriate	JJ
cord-006702-ekf6mja9	534	12	response	response	NN
cord-006702-ekf6mja9	534	13	:	:	:
cord-006702-ekf6mja9	534	14	kidney	kidney	NN
cord-006702-ekf6mja9	534	15	HIF2a	HIF2a	NNP
cord-006702-ekf6mja9	534	16	and	and	CC
cord-006702-ekf6mja9	534	17	BM	BM	NNP
cord-006702-ekf6mja9	534	18	EPO	EPO	NNP
cord-006702-ekf6mja9	534	19	are	be	VBP
cord-006702-ekf6mja9	534	20	not	not	RB
cord-006702-ekf6mja9	534	21	increased	increase	VBN
cord-006702-ekf6mja9	534	22	,	,	,
cord-006702-ekf6mja9	534	23	contrary	contrary	JJ
cord-006702-ekf6mja9	534	24	to	to	IN
cord-006702-ekf6mja9	534	25	what	what	WP
cord-006702-ekf6mja9	534	26	is	be	VBZ
cord-006702-ekf6mja9	534	27	normally	normally	RB
cord-006702-ekf6mja9	534	28	seen	see	VBN
cord-006702-ekf6mja9	534	29	after	after	IN
cord-006702-ekf6mja9	534	30	hemorrhage	hemorrhage	NN
cord-006702-ekf6mja9	534	31	.	.	.
cord-006702-ekf6mja9	535	1	In	in	IN
cord-006702-ekf6mja9	535	2	addition	addition	NN
cord-006702-ekf6mja9	535	3	,	,	,
cord-006702-ekf6mja9	535	4	BM	BM	NNP
cord-006702-ekf6mja9	535	5	and	and	CC
cord-006702-ekf6mja9	535	6	EGP	EGP	NNP
cord-006702-ekf6mja9	535	7	EPOR	EPOR	NNP
cord-006702-ekf6mja9	535	8	levels	level	NNS
cord-006702-ekf6mja9	535	9	are	be	VBP
cord-006702-ekf6mja9	535	10	reduced	reduce	VBN
cord-006702-ekf6mja9	535	11	,	,	,
cord-006702-ekf6mja9	535	12	as	as	RB
cord-006702-ekf6mja9	535	13	well	well	RB
cord-006702-ekf6mja9	535	14	as	as	IN
cord-006702-ekf6mja9	535	15	EGP	EGP	NNP
cord-006702-ekf6mja9	535	16	pSTAT5	pSTAT5	NNP
cord-006702-ekf6mja9	535	17	response	response	NN
cord-006702-ekf6mja9	535	18	to	to	IN
cord-006702-ekf6mja9	535	19	EPO	EPO	NNP
cord-006702-ekf6mja9	535	20	,	,	,
cord-006702-ekf6mja9	535	21	suggesting	suggest	VBG
cord-006702-ekf6mja9	535	22	EPO	EPO	NNP
cord-006702-ekf6mja9	535	23	resistance	resistance	NN
cord-006702-ekf6mja9	535	24	as	as	IN
cord-006702-ekf6mja9	535	25	an	an	DT
cord-006702-ekf6mja9	535	26	additional	additional	JJ
cord-006702-ekf6mja9	535	27	mechanism	mechanism	NN
cord-006702-ekf6mja9	535	28	.	.	.
cord-006702-ekf6mja9	536	1	S16	S16	NNP
cord-006702-ekf6mja9	536	2	-Developmental	-Developmental	NNP
cord-006702-ekf6mja9	536	3	nephrology	nephrology	NN
cord-006702-ekf6mja9	536	4	:	:	:
cord-006702-ekf6mja9	537	1	New	new	JJ
cord-006702-ekf6mja9	537	2	concepts	concept	NNS
cord-006702-ekf6mja9	537	3	FP	FP	NNP
cord-006702-ekf6mja9	537	4	-	-	HYPH
cord-006702-ekf6mja9	537	5	S16	S16	NNP
cord-006702-ekf6mja9	537	6	-	-	HYPH
cord-006702-ekf6mja9	537	7	1	1	CD
cord-006702-ekf6mja9	537	8	Promotion	Promotion	NNP
cord-006702-ekf6mja9	537	9	of	of	IN
cord-006702-ekf6mja9	537	10	USP4	USP4	NNP
cord-006702-ekf6mja9	537	11	to	to	IN
cord-006702-ekf6mja9	537	12	TGF	TGF	NNP
cord-006702-ekf6mja9	537	13	-	-	HYPH
cord-006702-ekf6mja9	537	14	β1-induced	β1-induce	VBN
cord-006702-ekf6mja9	537	15	EMT	EMT	NNP
cord-006702-ekf6mja9	537	16	in	in	IN
cord-006702-ekf6mja9	537	17	renal	renal	JJ
cord-006702-ekf6mja9	537	18	tubular	tubular	JJ
cord-006702-ekf6mja9	537	19	epithelial	epithelial	JJ
cord-006702-ekf6mja9	537	20	cells	cell	NNS
cord-006702-ekf6mja9	537	21	is	be	VBZ
cord-006702-ekf6mja9	537	22	regulated	regulate	VBN
cord-006702-ekf6mja9	537	23	by	by	IN
cord-006702-ekf6mja9	537	24	AKT	AKT	NNP
cord-006702-ekf6mja9	537	25	through	through	IN
cord-006702-ekf6mja9	537	26	stabilizing	stabilize	VBG
cord-006702-ekf6mja9	537	27	TβRI	TβRI	NNP
cord-006702-ekf6mja9	537	28	J.	J.	NNP
cord-006702-ekf6mja9	537	29	Zhou	Zhou	NNP
cord-006702-ekf6mja9	537	30	,	,	,
cord-006702-ekf6mja9	537	31	J.	J.	NNP
cord-006702-ekf6mja9	537	32	Pu	Pu	NNP
cord-006702-ekf6mja9	537	33	,	,	,
cord-006702-ekf6mja9	537	34	Y.	Y.	NNP
cord-006702-ekf6mja9	537	35	Zhang	Zhang	NNP
cord-006702-ekf6mja9	537	36	,	,	,
cord-006702-ekf6mja9	537	37	Z.	Z.	NNP
cord-006702-ekf6mja9	537	38	Huang	Huang	NNP
cord-006702-ekf6mja9	537	39	,	,	,
cord-006702-ekf6mja9	537	40	L.	L.	NNP
cord-006702-ekf6mja9	537	41	Wang	Wang	NNP
cord-006702-ekf6mja9	537	42	Tongji	Tongji	NNP
cord-006702-ekf6mja9	537	43	Hospital	Hospital	NNP
cord-006702-ekf6mja9	537	44	,	,	,
cord-006702-ekf6mja9	537	45	Tongji	Tongji	NNP
cord-006702-ekf6mja9	537	46	Medical	Medical	NNP
cord-006702-ekf6mja9	537	47	College	College	NNP
cord-006702-ekf6mja9	537	48	,	,	,
cord-006702-ekf6mja9	537	49	Huazhong	Huazhong	NNP
cord-006702-ekf6mja9	537	50	University	University	NNP
cord-006702-ekf6mja9	537	51	of	of	IN
cord-006702-ekf6mja9	537	52	Science	Science	NNP
cord-006702-ekf6mja9	537	53	and	and	CC
cord-006702-ekf6mja9	537	54	Technology	Technology	NNP
cord-006702-ekf6mja9	537	55	,	,	,
cord-006702-ekf6mja9	537	56	Wuhan	Wuhan	NNP
cord-006702-ekf6mja9	537	57	,	,	,
cord-006702-ekf6mja9	538	1	China	China	NNP
cord-006702-ekf6mja9	538	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	539	1	:	:	:
cord-006702-ekf6mja9	539	2	We	-PRON-	PRP
cord-006702-ekf6mja9	539	3	aimed	aim	VBD
cord-006702-ekf6mja9	539	4	to	to	TO
cord-006702-ekf6mja9	539	5	explore	explore	VB
cord-006702-ekf6mja9	539	6	the	the	DT
cord-006702-ekf6mja9	539	7	role	role	NN
cord-006702-ekf6mja9	539	8	of	of	IN
cord-006702-ekf6mja9	539	9	ubiquitin	ubiquitin	NN
cord-006702-ekf6mja9	539	10	-	-	HYPH
cord-006702-ekf6mja9	539	11	specific	specific	JJ
cord-006702-ekf6mja9	539	12	peptidase-4	peptidase-4	NN
cord-006702-ekf6mja9	539	13	(	(	-LRB-
cord-006702-ekf6mja9	539	14	USP4	USP4	NNP
cord-006702-ekf6mja9	539	15	)	)	-RRB-
cord-006702-ekf6mja9	539	16	in	in	IN
cord-006702-ekf6mja9	539	17	TGF	TGF	NNP
cord-006702-ekf6mja9	539	18	-	-	HYPH
cord-006702-ekf6mja9	539	19	β1	β1	NNP
cord-006702-ekf6mja9	539	20	induced	induce	VBN
cord-006702-ekf6mja9	539	21	epithelial	epithelial	NN
cord-006702-ekf6mja9	539	22	-	-	HYPH
cord-006702-ekf6mja9	539	23	mesenchymal	mesenchymal	JJ
cord-006702-ekf6mja9	539	24	transition	transition	NN
cord-006702-ekf6mja9	539	25	(	(	-LRB-
cord-006702-ekf6mja9	539	26	EMT	EMT	NNP
cord-006702-ekf6mja9	539	27	)	)	-RRB-
cord-006702-ekf6mja9	539	28	during	during	IN
cord-006702-ekf6mja9	539	29	renal	renal	JJ
cord-006702-ekf6mja9	539	30	fibrosis	fibrosis	NN
cord-006702-ekf6mja9	539	31	,	,	,
cord-006702-ekf6mja9	539	32	and	and	CC
cord-006702-ekf6mja9	539	33	investigated	investigate	VBD
cord-006702-ekf6mja9	539	34	that	that	IN
cord-006702-ekf6mja9	539	35	if	if	IN
cord-006702-ekf6mja9	539	36	decreased	decrease	VBN
cord-006702-ekf6mja9	539	37	activation	activation	NN
cord-006702-ekf6mja9	539	38	of	of	IN
cord-006702-ekf6mja9	539	39	Akt	Akt	NNP
cord-006702-ekf6mja9	539	40	exerted	exert	VBD
cord-006702-ekf6mja9	539	41	a	a	DT
cord-006702-ekf6mja9	539	42	critical	critical	JJ
cord-006702-ekf6mja9	539	43	effect	effect	NN
cord-006702-ekf6mja9	539	44	on	on	IN
cord-006702-ekf6mja9	539	45	EMT	EMT	NNP
cord-006702-ekf6mja9	539	46	via	via	IN
cord-006702-ekf6mja9	539	47	USP4	USP4	NNP
cord-006702-ekf6mja9	539	48	/	/	SYM
cord-006702-ekf6mja9	539	49	TβRI	TβRI	NNP
cord-006702-ekf6mja9	539	50	pathway	pathway	NN
cord-006702-ekf6mja9	539	51	.	.	.
cord-006702-ekf6mja9	540	1	Methods	method	NNS
cord-006702-ekf6mja9	540	2	:	:	:
cord-006702-ekf6mja9	540	3	USP4	USP4	NNP
cord-006702-ekf6mja9	540	4	,	,	,
cord-006702-ekf6mja9	540	5	pAkt	pAkt	NNP
cord-006702-ekf6mja9	540	6	and	and	CC
cord-006702-ekf6mja9	540	7	TβRI	tβri	NN
cord-006702-ekf6mja9	540	8	proteins	protein	NNS
cord-006702-ekf6mja9	540	9	in	in	IN
cord-006702-ekf6mja9	540	10	the	the	DT
cord-006702-ekf6mja9	540	11	obstructed	obstruct	VBN
cord-006702-ekf6mja9	540	12	kidneys	kidney	NNS
cord-006702-ekf6mja9	540	13	of	of	IN
cord-006702-ekf6mja9	540	14	unilateral	unilateral	JJ
cord-006702-ekf6mja9	540	15	ureteral	ureteral	JJ
cord-006702-ekf6mja9	540	16	obstruction	obstruction	NN
cord-006702-ekf6mja9	540	17	(	(	-LRB-
cord-006702-ekf6mja9	540	18	UUO	UUO	NNP
cord-006702-ekf6mja9	540	19	)	)	-RRB-
cord-006702-ekf6mja9	540	20	rats	rat	NNS
cord-006702-ekf6mja9	540	21	were	be	VBD
cord-006702-ekf6mja9	540	22	detected	detect	VBN
cord-006702-ekf6mja9	540	23	by	by	IN
cord-006702-ekf6mja9	540	24	immunohistochemistry	immunohistochemistry	NN
cord-006702-ekf6mja9	540	25	assay	assay	NN
cord-006702-ekf6mja9	540	26	and	and	CC
cord-006702-ekf6mja9	540	27	western	western	JJ
cord-006702-ekf6mja9	540	28	blot	blot	NN
cord-006702-ekf6mja9	540	29	method	method	NN
cord-006702-ekf6mja9	540	30	.	.	.
cord-006702-ekf6mja9	541	1	E	e	NN
cord-006702-ekf6mja9	541	2	-	-	NN
cord-006702-ekf6mja9	541	3	cadherin	cadherin	NN
cord-006702-ekf6mja9	541	4	,	,	,
cord-006702-ekf6mja9	541	5	α	α	NN
cord-006702-ekf6mja9	541	6	-	-	HYPH
cord-006702-ekf6mja9	541	7	SMA	SMA	NNP
cord-006702-ekf6mja9	541	8	,	,	,
cord-006702-ekf6mja9	541	9	USP4	USP4	NNP
cord-006702-ekf6mja9	541	10	and	and	CC
cord-006702-ekf6mja9	541	11	pAkt	pAkt	NNP
cord-006702-ekf6mja9	541	12	proteins	protein	NNS
cord-006702-ekf6mja9	541	13	in	in	IN
cord-006702-ekf6mja9	541	14	NRK-52E	nrk-52e	JJ
cord-006702-ekf6mja9	541	15	cells	cell	NNS
cord-006702-ekf6mja9	541	16	with	with	IN
cord-006702-ekf6mja9	541	17	different	different	JJ
cord-006702-ekf6mja9	541	18	concentration	concentration	NN
cord-006702-ekf6mja9	541	19	TGF	TGF	NNP
cord-006702-ekf6mja9	541	20	-	-	HYPH
cord-006702-ekf6mja9	541	21	β1	β1	NNP
cord-006702-ekf6mja9	541	22	were	be	VBD
cord-006702-ekf6mja9	541	23	detected	detect	VBN
cord-006702-ekf6mja9	541	24	at	at	IN
cord-006702-ekf6mja9	541	25	different	different	JJ
cord-006702-ekf6mja9	541	26	time	time	NN
cord-006702-ekf6mja9	541	27	points	point	NNS
cord-006702-ekf6mja9	541	28	.	.	.
cord-006702-ekf6mja9	542	1	NRK-52E	nrk-52e	NN
cord-006702-ekf6mja9	542	2	cells	cell	NNS
cord-006702-ekf6mja9	542	3	were	be	VBD
cord-006702-ekf6mja9	542	4	transfected	transfecte	VBN
cord-006702-ekf6mja9	542	5	with	with	IN
cord-006702-ekf6mja9	542	6	USP4-specific	USP4-specific	NNP
cord-006702-ekf6mja9	542	7	siRNA	siRNA	NNP
cord-006702-ekf6mja9	542	8	,	,	,
cord-006702-ekf6mja9	542	9	and	and	CC
cord-006702-ekf6mja9	542	10	then	then	RB
cord-006702-ekf6mja9	542	11	stimulated	stimulate	VBD
cord-006702-ekf6mja9	542	12	with	with	IN
cord-006702-ekf6mja9	542	13	10	10	CD
cord-006702-ekf6mja9	542	14	ng	ng	NN
cord-006702-ekf6mja9	542	15	/	/	SYM
cord-006702-ekf6mja9	542	16	ml	ml	NN
cord-006702-ekf6mja9	542	17	TGF	TGF	NNP
cord-006702-ekf6mja9	542	18	-	-	HYPH
cord-006702-ekf6mja9	542	19	β1	β1	NNP
cord-006702-ekf6mja9	542	20	for	for	IN
cord-006702-ekf6mja9	542	21	24h	24h	NNS
cord-006702-ekf6mja9	542	22	to	to	TO
cord-006702-ekf6mja9	542	23	detect	detect	VB
cord-006702-ekf6mja9	542	24	Ecadherin	Ecadherin	NNP
cord-006702-ekf6mja9	542	25	and	and	CC
cord-006702-ekf6mja9	542	26	Vimentin	Vimentin	NNP
cord-006702-ekf6mja9	542	27	,	,	,
cord-006702-ekf6mja9	542	28	E	e	NN
cord-006702-ekf6mja9	542	29	-	-	NN
cord-006702-ekf6mja9	542	30	cadherin	cadherin	NN
cord-006702-ekf6mja9	542	31	and	and	CC
cord-006702-ekf6mja9	542	32	TβRI	TβRI	NNP
cord-006702-ekf6mja9	542	33	by	by	IN
cord-006702-ekf6mja9	542	34	immunofluorescent	immunofluorescent	NNP
cord-006702-ekf6mja9	542	35	double	double	JJ
cord-006702-ekf6mja9	542	36	staining	staining	NN
cord-006702-ekf6mja9	542	37	assay	assay	NN
cord-006702-ekf6mja9	542	38	.	.	.
cord-006702-ekf6mja9	543	1	We	-PRON-	PRP
cord-006702-ekf6mja9	543	2	pre	pre	VBD
cord-006702-ekf6mja9	543	3	-	-	JJ
cord-006702-ekf6mja9	543	4	treated	treat	VBN
cord-006702-ekf6mja9	543	5	NRK-52E	NRK-52E	NNP
cord-006702-ekf6mja9	543	6	cells	cell	NNS
cord-006702-ekf6mja9	543	7	with	with	IN
cord-006702-ekf6mja9	543	8	PI3	pi3	NN
cord-006702-ekf6mja9	543	9	K	K	NNP
cord-006702-ekf6mja9	543	10	inhibitor	inhibitor	NN
cord-006702-ekf6mja9	543	11	LY294002	LY294002	NNP
cord-006702-ekf6mja9	543	12	followed	follow	VBD
cord-006702-ekf6mja9	543	13	by	by	IN
cord-006702-ekf6mja9	543	14	TGF	TGF	NNP
cord-006702-ekf6mja9	543	15	-	-	HYPH
cord-006702-ekf6mja9	543	16	β1	β1	NNP
cord-006702-ekf6mja9	543	17	to	to	TO
cord-006702-ekf6mja9	543	18	detect	detect	VB
cord-006702-ekf6mja9	543	19	pAkt	pAkt	NNP
cord-006702-ekf6mja9	543	20	,	,	,
cord-006702-ekf6mja9	543	21	E	e	NN
cord-006702-ekf6mja9	543	22	-	-	NN
cord-006702-ekf6mja9	543	23	cadherin	cadherin	NN
cord-006702-ekf6mja9	543	24	,	,	,
cord-006702-ekf6mja9	543	25	α	α	NN
cord-006702-ekf6mja9	543	26	-	-	HYPH
cord-006702-ekf6mja9	543	27	SMA	SMA	NNP
cord-006702-ekf6mja9	543	28	,	,	,
cord-006702-ekf6mja9	543	29	Vimentin	Vimentin	NNP
cord-006702-ekf6mja9	543	30	and	and	CC
cord-006702-ekf6mja9	543	31	TβRI	TβRI	NNP
cord-006702-ekf6mja9	543	32	protein	protein	NN
cord-006702-ekf6mja9	543	33	expression	expression	NN
cord-006702-ekf6mja9	543	34	level	level	NN
cord-006702-ekf6mja9	543	35	.	.	.
cord-006702-ekf6mja9	544	1	Meanwhile	meanwhile	RB
cord-006702-ekf6mja9	544	2	,	,	,
cord-006702-ekf6mja9	544	3	the	the	DT
cord-006702-ekf6mja9	544	4	location	location	NN
cord-006702-ekf6mja9	544	5	of	of	IN
cord-006702-ekf6mja9	544	6	USP4	USP4	NNP
cord-006702-ekf6mja9	544	7	was	be	VBD
cord-006702-ekf6mja9	544	8	visualized	visualize	VBN
cord-006702-ekf6mja9	544	9	by	by	IN
cord-006702-ekf6mja9	544	10	immunofluorescent	immunofluorescent	JJ
cord-006702-ekf6mja9	544	11	assay	assay	NN
cord-006702-ekf6mja9	544	12	in	in	IN
cord-006702-ekf6mja9	544	13	NRK-52E	NRK-52E	NNP
cord-006702-ekf6mja9	544	14	cells	cell	NNS
cord-006702-ekf6mja9	544	15	.	.	.
cord-006702-ekf6mja9	545	1	Results	result	NNS
cord-006702-ekf6mja9	545	2	:	:	:
cord-006702-ekf6mja9	546	1	The	the	DT
cord-006702-ekf6mja9	546	2	USP4	USP4	NNP
cord-006702-ekf6mja9	546	3	expression	expression	NN
cord-006702-ekf6mja9	546	4	was	be	VBD
cord-006702-ekf6mja9	546	5	upregulated	upregulate	VBN
cord-006702-ekf6mja9	546	6	in	in	IN
cord-006702-ekf6mja9	546	7	the	the	DT
cord-006702-ekf6mja9	546	8	tubular	tubular	JJ
cord-006702-ekf6mja9	546	9	epithelial	epithelial	JJ
cord-006702-ekf6mja9	546	10	cells	cell	NNS
cord-006702-ekf6mja9	546	11	of	of	IN
cord-006702-ekf6mja9	546	12	UUO	UUO	NNP
cord-006702-ekf6mja9	546	13	rats	rat	NNS
cord-006702-ekf6mja9	546	14	.	.	.
cord-006702-ekf6mja9	547	1	We	-PRON-	PRP
cord-006702-ekf6mja9	547	2	also	also	RB
cord-006702-ekf6mja9	547	3	found	find	VBD
cord-006702-ekf6mja9	547	4	that	that	IN
cord-006702-ekf6mja9	547	5	TGF	TGF	NNP
cord-006702-ekf6mja9	547	6	-	-	HYPH
cord-006702-ekf6mja9	547	7	β1	β1	NNP
cord-006702-ekf6mja9	547	8	upregulated	upregulate	VBD
cord-006702-ekf6mja9	547	9	USP4	usp4	JJ
cord-006702-ekf6mja9	547	10	expression	expression	NN
cord-006702-ekf6mja9	547	11	in	in	IN
cord-006702-ekf6mja9	547	12	NRK-52E	NRK-52E	NNP
cord-006702-ekf6mja9	547	13	cells	cell	NNS
cord-006702-ekf6mja9	547	14	during	during	IN
cord-006702-ekf6mja9	547	15	their	-PRON-	PRP$
cord-006702-ekf6mja9	547	16	EMT	EMT	NNP
cord-006702-ekf6mja9	547	17	.	.	.
cord-006702-ekf6mja9	548	1	Importantly	importantly	RB
cord-006702-ekf6mja9	548	2	,	,	,
cord-006702-ekf6mja9	548	3	depressed	depressed	JJ
cord-006702-ekf6mja9	548	4	expression	expression	NN
cord-006702-ekf6mja9	548	5	of	of	IN
cord-006702-ekf6mja9	548	6	USP4	USP4	NNP
cord-006702-ekf6mja9	548	7	inhibited	inhibit	VBD
cord-006702-ekf6mja9	548	8	TβRI	TβRI	NNP
cord-006702-ekf6mja9	548	9	expression	expression	NN
cord-006702-ekf6mja9	548	10	and	and	CC
cord-006702-ekf6mja9	548	11	partially	partially	RB
cord-006702-ekf6mja9	548	12	reversed	reverse	VBN
cord-006702-ekf6mja9	548	13	EMT	EMT	NNP
cord-006702-ekf6mja9	548	14	stimulated	stimulate	VBN
cord-006702-ekf6mja9	548	15	by	by	IN
cord-006702-ekf6mja9	548	16	TGF	TGF	NNP
cord-006702-ekf6mja9	548	17	-	-	HYPH
cord-006702-ekf6mja9	548	18	β1	β1	NNP
cord-006702-ekf6mja9	548	19	.	.	.
cord-006702-ekf6mja9	549	1	In	in	IN
cord-006702-ekf6mja9	549	2	the	the	DT
cord-006702-ekf6mja9	549	3	meantime	meantime	NN
cord-006702-ekf6mja9	549	4	,	,	,
cord-006702-ekf6mja9	549	5	blunted	blunt	VBN
cord-006702-ekf6mja9	550	1	phosphorylation	phosphorylation	NN
cord-006702-ekf6mja9	550	2	of	of	IN
cord-006702-ekf6mja9	550	3	Akt	Akt	NNP
cord-006702-ekf6mja9	550	4	promoted	promote	VBD
cord-006702-ekf6mja9	550	5	the	the	DT
cord-006702-ekf6mja9	550	6	E	e	NN
cord-006702-ekf6mja9	550	7	-	-	NN
cord-006702-ekf6mja9	550	8	cadherin	cadherin	JJ
cord-006702-ekf6mja9	550	9	expression	expression	NN
cord-006702-ekf6mja9	550	10	,	,	,
cord-006702-ekf6mja9	550	11	and	and	CC
cord-006702-ekf6mja9	550	12	inhibited	inhibited	JJ
cord-006702-ekf6mja9	550	13	α	α	NNP
cord-006702-ekf6mja9	550	14	-	-	HYPH
cord-006702-ekf6mja9	550	15	SMA	SMA	NNP
cord-006702-ekf6mja9	550	16	and	and	CC
cord-006702-ekf6mja9	550	17	Vimentin	Vimentin	NNP
cord-006702-ekf6mja9	550	18	expression	expression	NN
cord-006702-ekf6mja9	550	19	in	in	IN
cord-006702-ekf6mja9	550	20	response	response	NN
cord-006702-ekf6mja9	550	21	to	to	IN
cord-006702-ekf6mja9	550	22	TGF	TGF	NNP
cord-006702-ekf6mja9	550	23	-	-	HYPH
cord-006702-ekf6mja9	550	24	β1	β1	NNP
cord-006702-ekf6mja9	550	25	.	.	.
cord-006702-ekf6mja9	551	1	However	however	RB
cord-006702-ekf6mja9	551	2	,	,	,
cord-006702-ekf6mja9	551	3	inactivation	inactivation	NN
cord-006702-ekf6mja9	551	4	of	of	IN
cord-006702-ekf6mja9	551	5	Akt	Akt	NNP
cord-006702-ekf6mja9	551	6	failed	fail	VBD
cord-006702-ekf6mja9	551	7	to	to	TO
cord-006702-ekf6mja9	551	8	induce	induce	VB
cord-006702-ekf6mja9	551	9	USP4	USP4	NNP
cord-006702-ekf6mja9	551	10	to	to	TO
cord-006702-ekf6mja9	551	11	shuttle	shuttle	VB
cord-006702-ekf6mja9	551	12	between	between	IN
cord-006702-ekf6mja9	551	13	the	the	DT
cord-006702-ekf6mja9	551	14	nucleus	nucleus	NN
cord-006702-ekf6mja9	551	15	and	and	CC
cord-006702-ekf6mja9	551	16	the	the	DT
cord-006702-ekf6mja9	551	17	cytoplasm	cytoplasm	NN
cord-006702-ekf6mja9	551	18	in	in	IN
cord-006702-ekf6mja9	551	19	NRK-52E	NRK-52E	NNP
cord-006702-ekf6mja9	551	20	cells	cell	NNS
cord-006702-ekf6mja9	551	21	and	and	CC
cord-006702-ekf6mja9	551	22	EMT	EMT	NNP
cord-006702-ekf6mja9	551	23	process	process	NN
cord-006702-ekf6mja9	551	24	stimulated	stimulate	VBN
cord-006702-ekf6mja9	551	25	by	by	IN
cord-006702-ekf6mja9	551	26	TGF	TGF	NNP
cord-006702-ekf6mja9	551	27	-	-	HYPH
cord-006702-ekf6mja9	551	28	β1	β1	NNP
cord-006702-ekf6mja9	551	29	.	.	.
cord-006702-ekf6mja9	552	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	552	2	:	:	:
cord-006702-ekf6mja9	553	1	These	these	DT
cord-006702-ekf6mja9	553	2	data	datum	NNS
cord-006702-ekf6mja9	553	3	imply	imply	VBP
cord-006702-ekf6mja9	553	4	that	that	IN
cord-006702-ekf6mja9	553	5	USP4	USP4	NNP
cord-006702-ekf6mja9	553	6	is	be	VBZ
cord-006702-ekf6mja9	553	7	a	a	DT
cord-006702-ekf6mja9	553	8	harmless	harmless	JJ
cord-006702-ekf6mja9	553	9	molecule	molecule	NN
cord-006702-ekf6mja9	553	10	induced	induce	VBN
cord-006702-ekf6mja9	553	11	by	by	IN
cord-006702-ekf6mja9	553	12	TGF	TGF	NNP
cord-006702-ekf6mja9	553	13	-	-	HYPH
cord-006702-ekf6mja9	553	14	β1	β1	NNP
cord-006702-ekf6mja9	553	15	,	,	,
cord-006702-ekf6mja9	553	16	regulated	regulate	VBN
cord-006702-ekf6mja9	553	17	by	by	IN
cord-006702-ekf6mja9	553	18	Akt	Akt	NNP
cord-006702-ekf6mja9	553	19	activation	activation	NN
cord-006702-ekf6mja9	553	20	and	and	CC
cord-006702-ekf6mja9	553	21	promotes	promote	VBZ
cord-006702-ekf6mja9	553	22	TGF	TGF	NNP
cord-006702-ekf6mja9	553	23	-	-	HYPH
cord-006702-ekf6mja9	553	24	β1-induced	β1-induce	VBN
cord-006702-ekf6mja9	553	25	EMT	EMT	NNP
cord-006702-ekf6mja9	553	26	via	via	IN
cord-006702-ekf6mja9	553	27	TβRI	TβRI	NNP
cord-006702-ekf6mja9	553	28	during	during	IN
cord-006702-ekf6mja9	553	29	renal	renal	JJ
cord-006702-ekf6mja9	553	30	fibrosis	fibrosis	NN
cord-006702-ekf6mja9	553	31	.	.	.
cord-006702-ekf6mja9	554	1	FP	FP	NNP
cord-006702-ekf6mja9	554	2	-	-	HYPH
cord-006702-ekf6mja9	554	3	S16	S16	NNP
cord-006702-ekf6mja9	554	4	-	-	HYPH
cord-006702-ekf6mja9	554	5	2	2	NNP
cord-006702-ekf6mja9	554	6	Exploring	explore	VBG
cord-006702-ekf6mja9	554	7	the	the	DT
cord-006702-ekf6mja9	554	8	mechanism	mechanism	NN
cord-006702-ekf6mja9	554	9	of	of	IN
cord-006702-ekf6mja9	554	10	GEN1	GEN1	NNP
cord-006702-ekf6mja9	554	11	regulating	regulate	VBG
cord-006702-ekf6mja9	554	12	the	the	DT
cord-006702-ekf6mja9	554	13	development	development	NN
cord-006702-ekf6mja9	554	14	of	of	IN
cord-006702-ekf6mja9	554	15	metanephros	metanephros	NNP
cord-006702-ekf6mja9	554	16	in	in	IN
cord-006702-ekf6mja9	554	17	mice	mouse	NNS
cord-006702-ekf6mja9	554	18	and	and	CC
cord-006702-ekf6mja9	554	19	the	the	DT
cord-006702-ekf6mja9	554	20	association	association	NN
cord-006702-ekf6mja9	554	21	of	of	IN
cord-006702-ekf6mja9	554	22	GEN1	GEN1	NNP
cord-006702-ekf6mja9	554	23	X.	X.	NNP
cord-006702-ekf6mja9	554	24	Wang	Wang	NNP
cord-006702-ekf6mja9	554	25	(	(	-LRB-
cord-006702-ekf6mja9	554	26	1	1	CD
cord-006702-ekf6mja9	554	27	)	)	-RRB-
cord-006702-ekf6mja9	554	28	,	,	,
cord-006702-ekf6mja9	554	29	H.	H.	NNP
cord-006702-ekf6mja9	554	30	Wang	Wang	NNP
cord-006702-ekf6mja9	554	31	(	(	-LRB-
cord-006702-ekf6mja9	554	32	2	2	CD
cord-006702-ekf6mja9	554	33	)	)	-RRB-
cord-006702-ekf6mja9	554	34	,	,	,
cord-006702-ekf6mja9	554	35	Q.	Q.	NNP
cord-006702-ekf6mja9	554	36	Shen	Shen	NNP
cord-006702-ekf6mja9	554	37	(	(	-LRB-
cord-006702-ekf6mja9	554	38	1	1	CD
cord-006702-ekf6mja9	554	39	)	)	-RRB-
cord-006702-ekf6mja9	554	40	,	,	,
cord-006702-ekf6mja9	554	41	Y.	Y.	NNP
cord-006702-ekf6mja9	554	42	Zhang	Zhang	NNP
cord-006702-ekf6mja9	554	43	(	(	-LRB-
cord-006702-ekf6mja9	554	44	1	1	CD
cord-006702-ekf6mja9	554	45	)	)	-RRB-
cord-006702-ekf6mja9	554	46	,	,	,
cord-006702-ekf6mja9	554	47	J.	J.	NNP
cord-006702-ekf6mja9	554	48	Liu	Liu	NNP
cord-006702-ekf6mja9	554	49	(	(	-LRB-
cord-006702-ekf6mja9	554	50	1	1	CD
cord-006702-ekf6mja9	554	51	)	)	-RRB-
cord-006702-ekf6mja9	554	52	,	,	,
cord-006702-ekf6mja9	554	53	C.	C.	NNP
cord-006702-ekf6mja9	554	54	Wang	Wang	NNP
cord-006702-ekf6mja9	554	55	(	(	-LRB-
cord-006702-ekf6mja9	554	56	1	1	CD
cord-006702-ekf6mja9	554	57	)	)	-RRB-
cord-006702-ekf6mja9	554	58	,	,	,
cord-006702-ekf6mja9	554	59	X.	X.	NNP
cord-006702-ekf6mja9	554	60	Wu	Wu	NNP
cord-006702-ekf6mja9	554	61	(	(	-LRB-
cord-006702-ekf6mja9	554	62	2	2	CD
cord-006702-ekf6mja9	554	63	)	)	-RRB-
cord-006702-ekf6mja9	554	64	,	,	,
cord-006702-ekf6mja9	554	65	H.	H.	NNP
cord-006702-ekf6mja9	554	66	Xu	Xu	NNP
cord-006702-ekf6mja9	554	67	(	(	-LRB-
cord-006702-ekf6mja9	554	68	1	1	CD
cord-006702-ekf6mja9	554	69	)	)	-RRB-
cord-006702-ekf6mja9	554	70	(	(	-LRB-
cord-006702-ekf6mja9	554	71	1	1	LS
cord-006702-ekf6mja9	554	72	)	)	-RRB-
cord-006702-ekf6mja9	554	73	Children	Children	NNPS
cord-006702-ekf6mja9	554	74	's	's	POS
cord-006702-ekf6mja9	554	75	Hospital	Hospital	NNP
cord-006702-ekf6mja9	554	76	of	of	IN
cord-006702-ekf6mja9	554	77	Fudan	Fudan	NNP
cord-006702-ekf6mja9	554	78	University	University	NNP
cord-006702-ekf6mja9	554	79	,	,	,
cord-006702-ekf6mja9	554	80	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	554	81	,	,	,
cord-006702-ekf6mja9	554	82	China	China	NNP
cord-006702-ekf6mja9	554	83	;	;	:
cord-006702-ekf6mja9	554	84	(	(	-LRB-
cord-006702-ekf6mja9	554	85	2	2	LS
cord-006702-ekf6mja9	554	86	)	)	-RRB-
cord-006702-ekf6mja9	554	87	Institute	Institute	NNP
cord-006702-ekf6mja9	554	88	of	of	IN
cord-006702-ekf6mja9	554	89	developmental	developmental	JJ
cord-006702-ekf6mja9	554	90	biology	biology	NN
cord-006702-ekf6mja9	554	91	and	and	CC
cord-006702-ekf6mja9	554	92	molecular	molecular	JJ
cord-006702-ekf6mja9	554	93	medicine	medicine	NN
cord-006702-ekf6mja9	554	94	of	of	IN
cord-006702-ekf6mja9	554	95	Fudan	Fudan	NNP
cord-006702-ekf6mja9	554	96	University	University	NNP
cord-006702-ekf6mja9	554	97	,	,	,
cord-006702-ekf6mja9	554	98	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	554	99	,	,	,
cord-006702-ekf6mja9	555	1	China	China	NNP
cord-006702-ekf6mja9	555	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	555	3	:	:	:
cord-006702-ekf6mja9	556	1	GEN1	GEN1	NNP
cord-006702-ekf6mja9	556	2	was	be	VBD
cord-006702-ekf6mja9	556	3	recently	recently	RB
cord-006702-ekf6mja9	556	4	identified	identify	VBN
cord-006702-ekf6mja9	556	5	as	as	IN
cord-006702-ekf6mja9	556	6	a	a	DT
cord-006702-ekf6mja9	556	7	Holliday	Holliday	NNP
cord-006702-ekf6mja9	556	8	junction	junction	NN
cord-006702-ekf6mja9	556	9	resolvase	resolvase	NN
cord-006702-ekf6mja9	556	10	with	with	IN
cord-006702-ekf6mja9	556	11	a	a	DT
cord-006702-ekf6mja9	556	12	key	key	JJ
cord-006702-ekf6mja9	556	13	role	role	NN
cord-006702-ekf6mja9	556	14	in	in	IN
cord-006702-ekf6mja9	556	15	repair	repair	NN
cord-006702-ekf6mja9	556	16	of	of	IN
cord-006702-ekf6mja9	556	17	DNA	dna	NN
cord-006702-ekf6mja9	556	18	double	double	JJ
cord-006702-ekf6mja9	556	19	-	-	HYPH
cord-006702-ekf6mja9	556	20	strand	strand	NN
cord-006702-ekf6mja9	556	21	breaks	break	NNS
cord-006702-ekf6mja9	556	22	.	.	.
cord-006702-ekf6mja9	557	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	557	2	previous	previous	JJ
cord-006702-ekf6mja9	557	3	research	research	NN
cord-006702-ekf6mja9	557	4	found	find	VBD
cord-006702-ekf6mja9	557	5	that	that	IN
cord-006702-ekf6mja9	557	6	Gen1mutant	gen1mutant	NN
cord-006702-ekf6mja9	557	7	mice	mouse	NNS
cord-006702-ekf6mja9	557	8	showed	show	VBD
cord-006702-ekf6mja9	557	9	varied	varied	JJ
cord-006702-ekf6mja9	557	10	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	557	11	phenotypes	phenotype	NNS
cord-006702-ekf6mja9	557	12	.	.	.
cord-006702-ekf6mja9	558	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	558	2	goal	goal	NN
cord-006702-ekf6mja9	558	3	is	be	VBZ
cord-006702-ekf6mja9	558	4	to	to	TO
cord-006702-ekf6mja9	558	5	explore	explore	VB
cord-006702-ekf6mja9	558	6	the	the	DT
cord-006702-ekf6mja9	558	7	underlying	underlying	JJ
cord-006702-ekf6mja9	558	8	mechanism	mechanism	NN
cord-006702-ekf6mja9	558	9	that	that	WDT
cord-006702-ekf6mja9	558	10	Gen1	Gen1	NNP
cord-006702-ekf6mja9	558	11	may	may	MD
cord-006702-ekf6mja9	558	12	regulate	regulate	VB
cord-006702-ekf6mja9	558	13	the	the	DT
cord-006702-ekf6mja9	558	14	outgrowth	outgrowth	NN
cord-006702-ekf6mja9	558	15	and	and	CC
cord-006702-ekf6mja9	558	16	branching	branching	NN
cord-006702-ekf6mja9	558	17	of	of	IN
cord-006702-ekf6mja9	558	18	ureteric	ureteric	JJ
cord-006702-ekf6mja9	558	19	bud	bud	NN
cord-006702-ekf6mja9	558	20	(	(	-LRB-
cord-006702-ekf6mja9	558	21	UB	UB	NNP
cord-006702-ekf6mja9	558	22	)	)	-RRB-
cord-006702-ekf6mja9	558	23	.	.	.
cord-006702-ekf6mja9	559	1	Methods	method	NNS
cord-006702-ekf6mja9	559	2	:	:	:
cord-006702-ekf6mja9	559	3	By	by	IN
cord-006702-ekf6mja9	559	4	whole	whole	JJ
cord-006702-ekf6mja9	559	5	mount	mount	NN
cord-006702-ekf6mja9	559	6	in	in	IN
cord-006702-ekf6mja9	559	7	situ	situ	NN
cord-006702-ekf6mja9	559	8	hybridization	hybridization	NN
cord-006702-ekf6mja9	559	9	and	and	CC
cord-006702-ekf6mja9	559	10	real	real	JJ
cord-006702-ekf6mja9	559	11	-	-	HYPH
cord-006702-ekf6mja9	559	12	time	time	NN
cord-006702-ekf6mja9	559	13	PCR	PCR	NNP
cord-006702-ekf6mja9	559	14	,	,	,
cord-006702-ekf6mja9	559	15	we	-PRON-	PRP
cord-006702-ekf6mja9	559	16	identified	identify	VBD
cord-006702-ekf6mja9	559	17	the	the	DT
cord-006702-ekf6mja9	559	18	pattern	pattern	NN
cord-006702-ekf6mja9	559	19	and	and	CC
cord-006702-ekf6mja9	559	20	level	level	NN
cord-006702-ekf6mja9	559	21	of	of	IN
cord-006702-ekf6mja9	559	22	expression	expression	NN
cord-006702-ekf6mja9	559	23	of	of	IN
cord-006702-ekf6mja9	559	24	Gen1	Gen1	NNP
cord-006702-ekf6mja9	559	25	in	in	IN
cord-006702-ekf6mja9	559	26	the	the	DT
cord-006702-ekf6mja9	559	27	developing	develop	VBG
cord-006702-ekf6mja9	559	28	kidney	kidney	NN
cord-006702-ekf6mja9	559	29	of	of	IN
cord-006702-ekf6mja9	559	30	mice	mouse	NNS
cord-006702-ekf6mja9	559	31	.	.	.
cord-006702-ekf6mja9	560	1	We	-PRON-	PRP
cord-006702-ekf6mja9	560	2	analyzed	analyze	VBD
cord-006702-ekf6mja9	560	3	the	the	DT
cord-006702-ekf6mja9	560	4	characters	character	NNS
cord-006702-ekf6mja9	560	5	of	of	IN
cord-006702-ekf6mja9	560	6	varied	varied	JJ
cord-006702-ekf6mja9	560	7	phenotype	phenotype	NN
cord-006702-ekf6mja9	560	8	of	of	IN
cord-006702-ekf6mja9	560	9	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	560	10	in	in	IN
cord-006702-ekf6mja9	560	11	homozygous	homozygous	JJ
cord-006702-ekf6mja9	560	12	mice	mouse	NNS
cord-006702-ekf6mja9	560	13	.	.	.
cord-006702-ekf6mja9	561	1	Using	use	VBG
cord-006702-ekf6mja9	561	2	novel	novel	JJ
cord-006702-ekf6mja9	561	3	Hoxb7	Hoxb7	NNP
cord-006702-ekf6mja9	561	4	/	/	SYM
cord-006702-ekf6mja9	561	5	myr	myr	NNP
cord-006702-ekf6mja9	561	6	-	-	HYPH
cord-006702-ekf6mja9	561	7	Venus	Venus	NNP
cord-006702-ekf6mja9	561	8	transgenic	transgenic	JJ
cord-006702-ekf6mja9	561	9	mice	mouse	NNS
cord-006702-ekf6mja9	561	10	,	,	,
cord-006702-ekf6mja9	561	11	we	-PRON-	PRP
cord-006702-ekf6mja9	561	12	observed	observe	VBD
cord-006702-ekf6mja9	561	13	the	the	DT
cord-006702-ekf6mja9	561	14	budding	bud	VBG
cord-006702-ekf6mja9	561	15	and	and	CC
cord-006702-ekf6mja9	561	16	branching	branching	NN
cord-006702-ekf6mja9	561	17	of	of	IN
cord-006702-ekf6mja9	561	18	UB	ub	NN
cord-006702-ekf6mja9	561	19	of	of	IN
cord-006702-ekf6mja9	561	20	WTand	WTand	NNP
cord-006702-ekf6mja9	561	21	mutant	mutant	JJ
cord-006702-ekf6mja9	561	22	mice	mouse	NNS
cord-006702-ekf6mja9	561	23	,	,	,
cord-006702-ekf6mja9	561	24	both	both	CC
cord-006702-ekf6mja9	561	25	in	in	IN
cord-006702-ekf6mja9	561	26	vivo	vivo	NN
cord-006702-ekf6mja9	561	27	and	and	CC
cord-006702-ekf6mja9	561	28	in	in	IN
cord-006702-ekf6mja9	561	29	vitro	vitro	FW
cord-006702-ekf6mja9	561	30	.	.	.
cord-006702-ekf6mja9	562	1	By	by	IN
cord-006702-ekf6mja9	562	2	RNA	RNA	NNP
cord-006702-ekf6mja9	562	3	-	-	HYPH
cord-006702-ekf6mja9	562	4	seq	seq	NN
cord-006702-ekf6mja9	562	5	techniques	technique	NNS
cord-006702-ekf6mja9	562	6	,	,	,
cord-006702-ekf6mja9	562	7	we	-PRON-	PRP
cord-006702-ekf6mja9	562	8	further	further	RB
cord-006702-ekf6mja9	562	9	investigate	investigate	VBP
cord-006702-ekf6mja9	562	10	the	the	DT
cord-006702-ekf6mja9	562	11	different	different	JJ
cord-006702-ekf6mja9	562	12	expression	expression	NN
cord-006702-ekf6mja9	562	13	of	of	IN
cord-006702-ekf6mja9	562	14	related	related	JJ
cord-006702-ekf6mja9	562	15	transcriptions	transcription	NNS
cord-006702-ekf6mja9	562	16	after	after	IN
cord-006702-ekf6mja9	562	17	the	the	DT
cord-006702-ekf6mja9	562	18	disruption	disruption	NN
cord-006702-ekf6mja9	562	19	of	of	IN
cord-006702-ekf6mja9	562	20	Gen1	Gen1	NNP
cord-006702-ekf6mja9	562	21	.	.	.
cord-006702-ekf6mja9	563	1	Results	result	NNS
cord-006702-ekf6mja9	563	2	:	:	:
cord-006702-ekf6mja9	564	1	1	1	LS
cord-006702-ekf6mja9	564	2	)	)	-RRB-
cord-006702-ekf6mja9	565	1	Gen1	Gen1	NNP
cord-006702-ekf6mja9	565	2	is	be	VBZ
cord-006702-ekf6mja9	565	3	ubiquitously	ubiquitously	RB
cord-006702-ekf6mja9	565	4	expressed	express	VBN
cord-006702-ekf6mja9	565	5	in	in	IN
cord-006702-ekf6mja9	565	6	the	the	DT
cord-006702-ekf6mja9	565	7	mesoderm	mesoderm	NNS
cord-006702-ekf6mja9	565	8	of	of	IN
cord-006702-ekf6mja9	565	9	E10.5	E10.5	NNP
cord-006702-ekf6mja9	565	10	embryos	embryo	NNS
cord-006702-ekf6mja9	565	11	,	,	,
cord-006702-ekf6mja9	565	12	including	include	VBG
cord-006702-ekf6mja9	565	13	MM	MM	NNP
cord-006702-ekf6mja9	565	14	and	and	CC
cord-006702-ekf6mja9	565	15	UB	UB	NNP
cord-006702-ekf6mja9	565	16	regions	region	NNS
cord-006702-ekf6mja9	565	17	.	.	.
cord-006702-ekf6mja9	566	1	Over	over	IN
cord-006702-ekf6mja9	566	2	60	60	CD
cord-006702-ekf6mja9	566	3	%	%	NN
cord-006702-ekf6mja9	567	1	Gen1	Gen1	NNP
cord-006702-ekf6mja9	567	2	PB	PB	NNP
cord-006702-ekf6mja9	567	3	/	/	SYM
cord-006702-ekf6mja9	567	4	PB	PB	NNP
cord-006702-ekf6mja9	567	5	newborn	newborn	JJ
cord-006702-ekf6mja9	567	6	pups	pup	NNS
cord-006702-ekf6mja9	567	7	were	be	VBD
cord-006702-ekf6mja9	567	8	detected	detect	VBN
cord-006702-ekf6mja9	567	9	different	different	JJ
cord-006702-ekf6mja9	567	10	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	567	11	of	of	IN
cord-006702-ekf6mja9	567	12	kidney	kidney	NN
cord-006702-ekf6mja9	567	13	and	and	CC
cord-006702-ekf6mja9	567	14	urinary	urinary	JJ
cord-006702-ekf6mja9	567	15	tract	tract	NN
cord-006702-ekf6mja9	567	16	,	,	,
cord-006702-ekf6mja9	567	17	in	in	IN
cord-006702-ekf6mja9	567	18	which	which	WDT
cord-006702-ekf6mja9	567	19	duplex	duplex	NN
cord-006702-ekf6mja9	567	20	kidney	kidney	NN
cord-006702-ekf6mja9	567	21	were	be	VBD
cord-006702-ekf6mja9	567	22	the	the	DT
cord-006702-ekf6mja9	567	23	most	most	RBS
cord-006702-ekf6mja9	567	24	common	common	JJ
cord-006702-ekf6mja9	567	25	anomalies	anomaly	NNS
cord-006702-ekf6mja9	567	26	,	,	,
cord-006702-ekf6mja9	567	27	hydronephrosis	hydronephrosis	NN
cord-006702-ekf6mja9	567	28	,	,	,
cord-006702-ekf6mja9	567	29	renal	renal	JJ
cord-006702-ekf6mja9	567	30	agenesis	agenesis	NN
cord-006702-ekf6mja9	567	31	,	,	,
cord-006702-ekf6mja9	567	32	renal	renal	JJ
cord-006702-ekf6mja9	567	33	hypoplasia	hypoplasia	NN
cord-006702-ekf6mja9	567	34	,	,	,
cord-006702-ekf6mja9	567	35	VUR	VUR	NNP
cord-006702-ekf6mja9	567	36	and	and	CC
cord-006702-ekf6mja9	567	37	UVJO	UVJO	NNP
cord-006702-ekf6mja9	567	38	also	also	RB
cord-006702-ekf6mja9	567	39	were	be	VBD
cord-006702-ekf6mja9	567	40	not	not	RB
cord-006702-ekf6mja9	567	41	rare	rare	JJ
cord-006702-ekf6mja9	567	42	.	.	.
cord-006702-ekf6mja9	568	1	2	2	LS
cord-006702-ekf6mja9	568	2	)	)	-RRB-
cord-006702-ekf6mja9	569	1	Over	over	IN
cord-006702-ekf6mja9	569	2	50	50	CD
cord-006702-ekf6mja9	569	3	%	%	NN
cord-006702-ekf6mja9	570	1	Gen1	Gen1	NNP
cord-006702-ekf6mja9	570	2	PB/	PB/	NNS
cord-006702-ekf6mja9	571	1	PB	PB	NNP
cord-006702-ekf6mja9	571	2	mice	mouse	NNS
cord-006702-ekf6mja9	571	3	grew	grow	VBD
cord-006702-ekf6mja9	571	4	supernumerary	supernumerary	JJ
cord-006702-ekf6mja9	571	5	ectopic	ectopic	JJ
cord-006702-ekf6mja9	571	6	UB	ub	NN
cord-006702-ekf6mja9	571	7	.	.	.
cord-006702-ekf6mja9	572	1	The	the	DT
cord-006702-ekf6mja9	572	2	ND	ND	NNP
cord-006702-ekf6mja9	572	3	of	of	IN
cord-006702-ekf6mja9	572	4	E10.5d	E10.5d	NNPS
cord-006702-ekf6mja9	573	1	Gen1	Gen1	NNP
cord-006702-ekf6mja9	573	2	PB	PB	NNP
cord-006702-ekf6mja9	573	3	/	/	SYM
cord-006702-ekf6mja9	573	4	PB	PB	NNP
cord-006702-ekf6mja9	573	5	mice	mouse	NNS
cord-006702-ekf6mja9	573	6	cultured	culture	VBN
cord-006702-ekf6mja9	573	7	in	in	IN
cord-006702-ekf6mja9	573	8	vitro	vitro	FW
cord-006702-ekf6mja9	573	9	did	do	VBD
cord-006702-ekf6mja9	573	10	n't	not	RB
cord-006702-ekf6mja9	573	11	show	show	VB
cord-006702-ekf6mja9	573	12	higher	high	JJR
cord-006702-ekf6mja9	573	13	sensitivity	sensitivity	NN
cord-006702-ekf6mja9	573	14	to	to	IN
cord-006702-ekf6mja9	573	15	GDNF	GDNF	NNP
cord-006702-ekf6mja9	573	16	compared	compare	VBN
cord-006702-ekf6mja9	573	17	to	to	IN
cord-006702-ekf6mja9	573	18	WT	WT	NNP
cord-006702-ekf6mja9	573	19	mice	mouse	NNS
cord-006702-ekf6mja9	573	20	.	.	.
cord-006702-ekf6mja9	574	1	RNA	RNA	NNP
cord-006702-ekf6mja9	574	2	-	-	HYPH
cord-006702-ekf6mja9	574	3	seq	seq	NN
cord-006702-ekf6mja9	574	4	analysis	analysis	NN
cord-006702-ekf6mja9	574	5	of	of	IN
cord-006702-ekf6mja9	574	6	E10.5	E10.5	NNP
cord-006702-ekf6mja9	574	7	MM	MM	NNP
cord-006702-ekf6mja9	574	8	revealed	reveal	VBD
cord-006702-ekf6mja9	574	9	Grem1	Grem1	NNP
cord-006702-ekf6mja9	574	10	,	,	,
cord-006702-ekf6mja9	574	11	a	a	DT
cord-006702-ekf6mja9	574	12	BMP4	BMP4	NNP
cord-006702-ekf6mja9	574	13	antagonist	antagonist	NN
cord-006702-ekf6mja9	574	14	that	that	WDT
cord-006702-ekf6mja9	574	15	positively	positively	RB
cord-006702-ekf6mja9	574	16	regulates	regulate	VBZ
cord-006702-ekf6mja9	574	17	UB	UB	NNP
cord-006702-ekf6mja9	574	18	formation	formation	NN
cord-006702-ekf6mja9	574	19	,	,	,
cord-006702-ekf6mja9	574	20	as	as	IN
cord-006702-ekf6mja9	574	21	the	the	DT
cord-006702-ekf6mja9	574	22	only	only	JJ
cord-006702-ekf6mja9	574	23	gene	gene	NN
cord-006702-ekf6mja9	574	24	that	that	WDT
cord-006702-ekf6mja9	574	25	was	be	VBD
cord-006702-ekf6mja9	574	26	significantly	significantly	RB
cord-006702-ekf6mja9	574	27	up	up	RB
cord-006702-ekf6mja9	574	28	regulated	regulate	VBN
cord-006702-ekf6mja9	574	29	.	.	.
cord-006702-ekf6mja9	575	1	In	in	IN
cord-006702-ekf6mja9	575	2	situ	situ	JJ
cord-006702-ekf6mja9	575	3	hybridization	hybridization	NN
cord-006702-ekf6mja9	575	4	with	with	IN
cord-006702-ekf6mja9	575	5	an	an	DT
cord-006702-ekf6mja9	575	6	anti	anti	JJ
cord-006702-ekf6mja9	575	7	-	-	JJ
cord-006702-ekf6mja9	575	8	sense	sense	JJ
cord-006702-ekf6mja9	575	9	RNA	RNA	NNP
cord-006702-ekf6mja9	575	10	probe	probe	NN
cord-006702-ekf6mja9	575	11	confirmed	confirm	VBD
cord-006702-ekf6mja9	575	12	Grem1	Grem1	NNP
cord-006702-ekf6mja9	575	13	up	up	IN
cord-006702-ekf6mja9	575	14	-	-	HYPH
cord-006702-ekf6mja9	575	15	regulation	regulation	NN
cord-006702-ekf6mja9	575	16	inGen1	inGen1	NNS
cord-006702-ekf6mja9	575	17	PB	PB	NNP
cord-006702-ekf6mja9	575	18	/	/	SYM
cord-006702-ekf6mja9	575	19	PB	PB	NNP
cord-006702-ekf6mja9	575	20	embryos	embryo	NNS
cord-006702-ekf6mja9	575	21	.	.	.
cord-006702-ekf6mja9	576	1	3	3	LS
cord-006702-ekf6mja9	576	2	)	)	-RRB-
cord-006702-ekf6mja9	577	1	The	the	DT
cord-006702-ekf6mja9	577	2	number	number	NN
cord-006702-ekf6mja9	577	3	of	of	IN
cord-006702-ekf6mja9	577	4	tips	tip	NNS
cord-006702-ekf6mja9	577	5	of	of	IN
cord-006702-ekf6mja9	577	6	branching	branch	VBG
cord-006702-ekf6mja9	577	7	UB	UB	NNP
cord-006702-ekf6mja9	577	8	was	be	VBD
cord-006702-ekf6mja9	577	9	significantly	significantly	RB
cord-006702-ekf6mja9	577	10	reduced	reduce	VBN
cord-006702-ekf6mja9	577	11	in	in	IN
cord-006702-ekf6mja9	577	12	Gen1	Gen1	NNP
cord-006702-ekf6mja9	577	13	PB	PB	NNP
cord-006702-ekf6mja9	577	14	/	/	SYM
cord-006702-ekf6mja9	577	15	PB	PB	NNP
cord-006702-ekf6mja9	577	16	mice	mouse	NNS
cord-006702-ekf6mja9	577	17	,	,	,
cord-006702-ekf6mja9	577	18	bothin	bothin	NNP
cord-006702-ekf6mja9	577	19	vivo	vivo	NNP
cord-006702-ekf6mja9	577	20	andin	andin	NNP
cord-006702-ekf6mja9	577	21	vitro	vitro	FW
cord-006702-ekf6mja9	577	22	cultured	cultured	JJ
cord-006702-ekf6mja9	577	23	explants	explant	NNS
cord-006702-ekf6mja9	577	24	.	.	.
cord-006702-ekf6mja9	578	1	The	the	DT
cord-006702-ekf6mja9	578	2	suppression	suppression	NN
cord-006702-ekf6mja9	578	3	on	on	IN
cord-006702-ekf6mja9	578	4	branching	branch	VBG
cord-006702-ekf6mja9	578	5	in	in	IN
cord-006702-ekf6mja9	578	6	Gen1	Gen1	NNP
cord-006702-ekf6mja9	578	7	PB	PB	NNP
cord-006702-ekf6mja9	578	8	/	/	SYM
cord-006702-ekf6mja9	578	9	PB	PB	NNP
cord-006702-ekf6mja9	578	10	mice	mouse	NNS
cord-006702-ekf6mja9	578	11	may	may	MD
cord-006702-ekf6mja9	578	12	due	due	IN
cord-006702-ekf6mja9	578	13	to	to	IN
cord-006702-ekf6mja9	578	14	the	the	DT
cord-006702-ekf6mja9	578	15	consistently	consistently	RB
cord-006702-ekf6mja9	578	16	down	down	JJ
cord-006702-ekf6mja9	578	17	-	-	HYPH
cord-006702-ekf6mja9	578	18	regulation	regulation	NN
cord-006702-ekf6mja9	578	19	of	of	IN
cord-006702-ekf6mja9	578	20	Six2	Six2	NNP
cord-006702-ekf6mja9	578	21	,	,	,
cord-006702-ekf6mja9	578	22	which	which	WDT
cord-006702-ekf6mja9	578	23	play	play	VBP
cord-006702-ekf6mja9	578	24	an	an	DT
cord-006702-ekf6mja9	578	25	important	important	JJ
cord-006702-ekf6mja9	578	26	role	role	NN
cord-006702-ekf6mja9	578	27	in	in	IN
cord-006702-ekf6mja9	578	28	the	the	DT
cord-006702-ekf6mja9	578	29	branching	branch	VBG
cord-006702-ekf6mja9	578	30	development	development	NN
cord-006702-ekf6mja9	578	31	.	.	.
cord-006702-ekf6mja9	579	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	579	2	:	:	:
cord-006702-ekf6mja9	580	1	This	this	DT
cord-006702-ekf6mja9	580	2	study	study	NN
cord-006702-ekf6mja9	580	3	reports	report	VBZ
cord-006702-ekf6mja9	580	4	good	good	JJ
cord-006702-ekf6mja9	580	5	short	short	JJ
cord-006702-ekf6mja9	580	6	-	-	HYPH
cord-006702-ekf6mja9	580	7	term	term	NN
cord-006702-ekf6mja9	580	8	renal	renal	JJ
cord-006702-ekf6mja9	580	9	allograft	allograft	NN
cord-006702-ekf6mja9	580	10	survival	survival	NN
cord-006702-ekf6mja9	580	11	in	in	IN
cord-006702-ekf6mja9	580	12	kidneys	kidney	NNS
cord-006702-ekf6mja9	580	13	that	that	WDT
cord-006702-ekf6mja9	580	14	were	be	VBD
cord-006702-ekf6mja9	580	15	initially	initially	RB
cord-006702-ekf6mja9	580	16	declined	decline	VBN
cord-006702-ekf6mja9	580	17	for	for	IN
cord-006702-ekf6mja9	580	18	paediatric	paediatric	JJ
cord-006702-ekf6mja9	580	19	recipients	recipient	NNS
cord-006702-ekf6mja9	580	20	and	and	CC
cord-006702-ekf6mja9	580	21	then	then	RB
cord-006702-ekf6mja9	580	22	subsequently	subsequently	RB
cord-006702-ekf6mja9	580	23	transplanted	transplant	VBD
cord-006702-ekf6mja9	580	24	.	.	.
cord-006702-ekf6mja9	581	1	While	while	IN
cord-006702-ekf6mja9	581	2	most	most	JJS
cord-006702-ekf6mja9	581	3	children	child	NNS
cord-006702-ekf6mja9	581	4	who	who	WP
cord-006702-ekf6mja9	581	5	have	have	VBP
cord-006702-ekf6mja9	581	6	a	a	DT
cord-006702-ekf6mja9	581	7	kidney	kidney	NN
cord-006702-ekf6mja9	581	8	declined	decline	VBD
cord-006702-ekf6mja9	581	9	on	on	IN
cord-006702-ekf6mja9	581	10	their	-PRON-	PRP$
cord-006702-ekf6mja9	581	11	behalf	behalf	NN
cord-006702-ekf6mja9	581	12	will	will	MD
cord-006702-ekf6mja9	581	13	eventually	eventually	RB
cord-006702-ekf6mja9	581	14	be	be	VB
cord-006702-ekf6mja9	581	15	transplanted	transplant	VBN
cord-006702-ekf6mja9	581	16	,	,	,
cord-006702-ekf6mja9	581	17	they	-PRON-	PRP
cord-006702-ekf6mja9	581	18	wait	wait	VBP
cord-006702-ekf6mja9	581	19	more	more	JJR
cord-006702-ekf6mja9	581	20	than	than	IN
cord-006702-ekf6mja9	581	21	6	6	CD
cord-006702-ekf6mja9	581	22	months	month	NNS
cord-006702-ekf6mja9	581	23	on	on	IN
cord-006702-ekf6mja9	581	24	average	average	JJ
cord-006702-ekf6mja9	581	25	to	to	TO
cord-006702-ekf6mja9	581	26	get	get	VB
cord-006702-ekf6mja9	581	27	a	a	DT
cord-006702-ekf6mja9	581	28	kidney	kidney	NN
cord-006702-ekf6mja9	581	29	transplant	transplant	NN
cord-006702-ekf6mja9	581	30	.	.	.
cord-006702-ekf6mja9	582	1	In	in	IN
cord-006702-ekf6mja9	582	2	view	view	NN
cord-006702-ekf6mja9	582	3	of	of	IN
cord-006702-ekf6mja9	582	4	the	the	DT
cord-006702-ekf6mja9	582	5	advantages	advantage	NNS
cord-006702-ekf6mja9	582	6	of	of	IN
cord-006702-ekf6mja9	582	7	timely	timely	JJ
cord-006702-ekf6mja9	582	8	transplantation	transplantation	NN
cord-006702-ekf6mja9	582	9	in	in	IN
cord-006702-ekf6mja9	582	10	children	child	NNS
cord-006702-ekf6mja9	582	11	,	,	,
cord-006702-ekf6mja9	582	12	criteria	criterion	NNS
cord-006702-ekf6mja9	582	13	for	for	IN
cord-006702-ekf6mja9	582	14	accepting	accept	VBG
cord-006702-ekf6mja9	582	15	kidneys	kidney	NNS
cord-006702-ekf6mja9	582	16	for	for	IN
cord-006702-ekf6mja9	582	17	paediatric	paediatric	JJ
cord-006702-ekf6mja9	582	18	recipients	recipient	NNS
cord-006702-ekf6mja9	582	19	could	could	MD
cord-006702-ekf6mja9	582	20	be	be	VB
cord-006702-ekf6mja9	582	21	reviewed	review	VBN
cord-006702-ekf6mja9	582	22	.	.	.
cord-006702-ekf6mja9	583	1	FP	FP	NNP
cord-006702-ekf6mja9	583	2	-	-	HYPH
cord-006702-ekf6mja9	583	3	S17	S17	NNP
cord-006702-ekf6mja9	583	4	-	-	HYPH
cord-006702-ekf6mja9	583	5	2	2	CD
cord-006702-ekf6mja9	584	1	The	the	DT
cord-006702-ekf6mja9	584	2	effect	effect	NN
cord-006702-ekf6mja9	584	3	of	of	IN
cord-006702-ekf6mja9	584	4	donor	donor	NN
cord-006702-ekf6mja9	584	5	-	-	HYPH
cord-006702-ekf6mja9	584	6	recipient	recipient	NN
cord-006702-ekf6mja9	584	7	age	age	NN
cord-006702-ekf6mja9	584	8	-	-	HYPH
cord-006702-ekf6mja9	584	9	matching	match	VBG
cord-006702-ekf6mja9	584	10	on	on	IN
cord-006702-ekf6mja9	584	11	graft	graft	NN
cord-006702-ekf6mja9	584	12	survival	survival	NN
cord-006702-ekf6mja9	584	13	in	in	IN
cord-006702-ekf6mja9	584	14	pediatric	pediatric	JJ
cord-006702-ekf6mja9	584	15	renal	renal	JJ
cord-006702-ekf6mja9	584	16	transplant	transplant	NN
cord-006702-ekf6mja9	584	17	recipients	recipient	NNS
cord-006702-ekf6mja9	584	18	-an	-an	.
cord-006702-ekf6mja9	585	1	ESPN	ESPN	NNP
cord-006702-ekf6mja9	585	2	/	/	SYM
cord-006702-ekf6mja9	585	3	ERA	ERA	NNP
cord-006702-ekf6mja9	585	4	-	-	HYPH
cord-006702-ekf6mja9	585	5	EDTA	EDTA	NNP
cord-006702-ekf6mja9	585	6	Registry	Registry	NNP
cord-006702-ekf6mja9	585	7	study	study	NN
cord-006702-ekf6mja9	585	8	N.	N.	NNP
cord-006702-ekf6mja9	585	9	Chesnaye	Chesnaye	NNP
cord-006702-ekf6mja9	585	10	(	(	-LRB-
cord-006702-ekf6mja9	585	11	1	1	CD
cord-006702-ekf6mja9	585	12	)	)	-RRB-
cord-006702-ekf6mja9	585	13	,	,	,
cord-006702-ekf6mja9	585	14	K.J.	K.J.	NNP
cord-006702-ekf6mja9	585	15	Van	Van	NNP
cord-006702-ekf6mja9	585	16	Stralen	Stralen	NNP
cord-006702-ekf6mja9	585	17	(	(	-LRB-
cord-006702-ekf6mja9	585	18	1	1	CD
cord-006702-ekf6mja9	585	19	)	)	-RRB-
cord-006702-ekf6mja9	585	20	,	,	,
cord-006702-ekf6mja9	585	21	M.	M.	NNP
cord-006702-ekf6mja9	585	22	Bonthuis	Bonthuis	NNP
cord-006702-ekf6mja9	585	23	(	(	-LRB-
cord-006702-ekf6mja9	585	24	1	1	CD
cord-006702-ekf6mja9	585	25	)	)	-RRB-
cord-006702-ekf6mja9	585	26	,	,	,
cord-006702-ekf6mja9	585	27	J.W.	J.W.	NNP
cord-006702-ekf6mja9	585	28	Groothoff	Groothoff	NNP
cord-006702-ekf6mja9	585	29	(	(	-LRB-
cord-006702-ekf6mja9	585	30	2	2	CD
cord-006702-ekf6mja9	585	31	)	)	-RRB-
cord-006702-ekf6mja9	585	32	,	,	,
cord-006702-ekf6mja9	585	33	J.	J.	NNP
cord-006702-ekf6mja9	585	34	Harambat	Harambat	NNP
cord-006702-ekf6mja9	585	35	(	(	-LRB-
cord-006702-ekf6mja9	585	36	3	3	CD
cord-006702-ekf6mja9	585	37	)	)	-RRB-
cord-006702-ekf6mja9	585	38	,	,	,
cord-006702-ekf6mja9	585	39	F.	F.	NNP
cord-006702-ekf6mja9	585	40	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	585	41	(	(	-LRB-
cord-006702-ekf6mja9	585	42	4	4	CD
cord-006702-ekf6mja9	585	43	)	)	-RRB-
cord-006702-ekf6mja9	585	44	,	,	,
cord-006702-ekf6mja9	585	45	K.J.	K.J.	NNP
cord-006702-ekf6mja9	585	46	Jager	Jager	NNP
cord-006702-ekf6mja9	585	47	(	(	-LRB-
cord-006702-ekf6mja9	585	48	1	1	CD
cord-006702-ekf6mja9	585	49	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	585	50	:	:	:
cord-006702-ekf6mja9	586	1	We	-PRON-	PRP
cord-006702-ekf6mja9	586	2	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	586	3	a	a	DT
cord-006702-ekf6mja9	586	4	differential	differential	JJ
cord-006702-ekf6mja9	586	5	risk	risk	NN
cord-006702-ekf6mja9	586	6	of	of	IN
cord-006702-ekf6mja9	586	7	graft	graft	NN
cord-006702-ekf6mja9	586	8	failure	failure	NN
cord-006702-ekf6mja9	586	9	dependent	dependent	JJ
cord-006702-ekf6mja9	586	10	on	on	IN
cord-006702-ekf6mja9	586	11	recipient	recipient	NN
cord-006702-ekf6mja9	586	12	and	and	CC
cord-006702-ekf6mja9	586	13	DD	DD	NNP
cord-006702-ekf6mja9	586	14	age	age	NN
cord-006702-ekf6mja9	586	15	combinations	combination	NNS
cord-006702-ekf6mja9	586	16	.	.	.
cord-006702-ekf6mja9	587	1	In	in	IN
cord-006702-ekf6mja9	587	2	the	the	DT
cord-006702-ekf6mja9	587	3	youngest	young	JJS
cord-006702-ekf6mja9	587	4	recipients	recipient	NNS
cord-006702-ekf6mja9	587	5	,	,	,
cord-006702-ekf6mja9	587	6	DD	DD	NNP
cord-006702-ekf6mja9	587	7	agematching	agematching	NN
cord-006702-ekf6mja9	587	8	results	result	NNS
cord-006702-ekf6mja9	587	9	in	in	IN
cord-006702-ekf6mja9	587	10	a	a	DT
cord-006702-ekf6mja9	587	11	higher	high	JJR
cord-006702-ekf6mja9	587	12	risk	risk	NN
cord-006702-ekf6mja9	587	13	of	of	IN
cord-006702-ekf6mja9	587	14	graft	graft	NN
cord-006702-ekf6mja9	587	15	failure	failure	NN
cord-006702-ekf6mja9	587	16	compared	compare	VBN
cord-006702-ekf6mja9	587	17	to	to	IN
cord-006702-ekf6mja9	587	18	the	the	DT
cord-006702-ekf6mja9	587	19	allocation	allocation	NN
cord-006702-ekf6mja9	587	20	of	of	IN
cord-006702-ekf6mja9	587	21	slightly	slightly	RB
cord-006702-ekf6mja9	587	22	older	old	JJR
cord-006702-ekf6mja9	587	23	-	-	HYPH
cord-006702-ekf6mja9	587	24	than	than	IN
cord-006702-ekf6mja9	587	25	-	-	HYPH
cord-006702-ekf6mja9	587	26	recipient	recipient	NN
cord-006702-ekf6mja9	587	27	DD	DD	NNP
cord-006702-ekf6mja9	587	28	grafts	graft	NNS
cord-006702-ekf6mja9	587	29	.	.	.
cord-006702-ekf6mja9	588	1	Objectives	objective	NNS
cord-006702-ekf6mja9	588	2	:	:	:
cord-006702-ekf6mja9	588	3	To	to	TO
cord-006702-ekf6mja9	588	4	characterise	characterise	VB
cord-006702-ekf6mja9	588	5	impact	impact	NN
cord-006702-ekf6mja9	588	6	of	of	IN
cord-006702-ekf6mja9	588	7	complement	complement	JJ
cord-006702-ekf6mja9	588	8	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	588	9	on	on	IN
cord-006702-ekf6mja9	588	10	phenotypes	phenotype	NNS
cord-006702-ekf6mja9	588	11	and	and	CC
cord-006702-ekf6mja9	588	12	outcomes	outcome	NNS
cord-006702-ekf6mja9	588	13	of	of	IN
cord-006702-ekf6mja9	588	14	patients	patient	NNS
cord-006702-ekf6mja9	588	15	(	(	-LRB-
cord-006702-ekf6mja9	588	16	pts	pt	NNS
cord-006702-ekf6mja9	588	17	)	)	-RRB-
cord-006702-ekf6mja9	588	18	with	with	IN
cord-006702-ekf6mja9	588	19	atypical	atypical	JJ
cord-006702-ekf6mja9	588	20	haemolytic	haemolytic	JJ
cord-006702-ekf6mja9	588	21	uraemic	uraemic	JJ
cord-006702-ekf6mja9	588	22	syndrome	syndrome	NN
cord-006702-ekf6mja9	588	23	(	(	-LRB-
cord-006702-ekf6mja9	588	24	aHUS	aHUS	NNP
cord-006702-ekf6mja9	588	25	)	)	-RRB-
cord-006702-ekf6mja9	588	26	enrolled	enrol	VBN
cord-006702-ekf6mja9	588	27	in	in	IN
cord-006702-ekf6mja9	588	28	the	the	DT
cord-006702-ekf6mja9	588	29	global	global	JJ
cord-006702-ekf6mja9	588	30	aHUS	ahus	DT
cord-006702-ekf6mja9	588	31	registry	registry	NN
cord-006702-ekf6mja9	588	32	prior	prior	RB
cord-006702-ekf6mja9	588	33	to	to	IN
cord-006702-ekf6mja9	588	34	eculizumab	eculizumab	NNP
cord-006702-ekf6mja9	588	35	treatment	treatment	NN
cord-006702-ekf6mja9	588	36	.	.	.
cord-006702-ekf6mja9	589	1	Methods	method	NNS
cord-006702-ekf6mja9	589	2	:	:	:
cord-006702-ekf6mja9	589	3	All	all	DT
cord-006702-ekf6mja9	589	4	pts	pt	NNS
cord-006702-ekf6mja9	589	5	with	with	IN
cord-006702-ekf6mja9	589	6	aHUS	ahus	DT
cord-006702-ekf6mja9	589	7	are	be	VBP
cord-006702-ekf6mja9	589	8	eligible	eligible	JJ
cord-006702-ekf6mja9	589	9	.	.	.
cord-006702-ekf6mja9	590	1	Demographics	demographic	NNS
cord-006702-ekf6mja9	590	2	,	,	,
cord-006702-ekf6mja9	590	3	medical	medical	JJ
cord-006702-ekf6mja9	590	4	history	history	NN
cord-006702-ekf6mja9	590	5	,	,	,
cord-006702-ekf6mja9	590	6	and	and	CC
cord-006702-ekf6mja9	590	7	treatment	treatment	NN
cord-006702-ekf6mja9	590	8	outcomes	outcome	NNS
cord-006702-ekf6mja9	590	9	data	datum	NNS
cord-006702-ekf6mja9	590	10	are	be	VBP
cord-006702-ekf6mja9	590	11	collected	collect	VBN
cord-006702-ekf6mja9	590	12	at	at	IN
cord-006702-ekf6mja9	590	13	enrolment	enrolment	NN
cord-006702-ekf6mja9	590	14	and	and	CC
cord-006702-ekf6mja9	590	15	then	then	RB
cord-006702-ekf6mja9	590	16	every	every	DT
cord-006702-ekf6mja9	590	17	six	six	CD
cord-006702-ekf6mja9	590	18	months	month	NNS
cord-006702-ekf6mja9	590	19	.	.	.
cord-006702-ekf6mja9	591	1	Results	result	NNS
cord-006702-ekf6mja9	591	2	:	:	:
cord-006702-ekf6mja9	592	1	As	as	IN
cord-006702-ekf6mja9	592	2	of	of	IN
cord-006702-ekf6mja9	592	3	November	November	NNP
cord-006702-ekf6mja9	592	4	2015	2015	CD
cord-006702-ekf6mja9	592	5	,	,	,
cord-006702-ekf6mja9	592	6	846	846	CD
cord-006702-ekf6mja9	592	7	pts	pt	NNS
cord-006702-ekf6mja9	592	8	were	be	VBD
cord-006702-ekf6mja9	592	9	enrolled	enrol	VBN
cord-006702-ekf6mja9	592	10	(	(	-LRB-
cord-006702-ekf6mja9	592	11	384	384	CD
cord-006702-ekf6mja9	592	12	childhood	childhood	NN
cord-006702-ekf6mja9	592	13	,	,	,
cord-006702-ekf6mja9	592	14	462	462	CD
cord-006702-ekf6mja9	592	15	adult	adult	NN
cord-006702-ekf6mja9	592	16	onset	onset	NN
cord-006702-ekf6mja9	592	17	)	)	-RRB-
cord-006702-ekf6mja9	592	18	.	.	.
cord-006702-ekf6mja9	593	1	Family	family	NN
cord-006702-ekf6mja9	593	2	history	history	NN
cord-006702-ekf6mja9	593	3	of	of	IN
cord-006702-ekf6mja9	593	4	aHUS	ahus	DT
cord-006702-ekf6mja9	593	5	was	be	VBD
cord-006702-ekf6mja9	593	6	positive	positive	JJ
cord-006702-ekf6mja9	593	7	in	in	IN
cord-006702-ekf6mja9	593	8	16	16	CD
cord-006702-ekf6mja9	593	9	%	%	NN
cord-006702-ekf6mja9	593	10	.	.	.
cord-006702-ekf6mja9	594	1	Median	median	JJ
cord-006702-ekf6mja9	594	2	age	age	NN
cord-006702-ekf6mja9	594	3	at	at	IN
cord-006702-ekf6mja9	594	4	first	first	RB
cord-006702-ekf6mja9	595	1	aHUS	ahus	DT
cord-006702-ekf6mja9	595	2	manifestation	manifestation	NN
cord-006702-ekf6mja9	595	3	was	be	VBD
cord-006702-ekf6mja9	595	4	7.2	7.2	CD
cord-006702-ekf6mja9	595	5	,	,	,
cord-006702-ekf6mja9	595	6	7.7	7.7	CD
cord-006702-ekf6mja9	595	7	,	,	,
cord-006702-ekf6mja9	595	8	18.5	18.5	CD
cord-006702-ekf6mja9	595	9	and	and	CC
cord-006702-ekf6mja9	595	10	34.3	34.3	CD
cord-006702-ekf6mja9	595	11	years	year	NNS
cord-006702-ekf6mja9	595	12	in	in	IN
cord-006702-ekf6mja9	595	13	pts	pts	NN
cord-006702-ekf6mja9	595	14	with	with	IN
cord-006702-ekf6mja9	595	15	MCP	MCP	NNP
cord-006702-ekf6mja9	595	16	,	,	,
cord-006702-ekf6mja9	595	17	C3	C3	NNP
cord-006702-ekf6mja9	595	18	,	,	,
cord-006702-ekf6mja9	595	19	CFH	CFH	NNP
cord-006702-ekf6mja9	595	20	and	and	CC
cord-006702-ekf6mja9	595	21	CFI	CFI	NNP
cord-006702-ekf6mja9	595	22	mutations	mutation	NNS
cord-006702-ekf6mja9	595	23	,	,	,
cord-006702-ekf6mja9	595	24	respectively	respectively	RB
cord-006702-ekf6mja9	595	25	,	,	,
cord-006702-ekf6mja9	595	26	and	and	CC
cord-006702-ekf6mja9	595	27	8.4	8.4	CD
cord-006702-ekf6mja9	595	28	years	year	NNS
cord-006702-ekf6mja9	595	29	for	for	IN
cord-006702-ekf6mja9	595	30	pts	pt	NNS
cord-006702-ekf6mja9	595	31	with	with	IN
cord-006702-ekf6mja9	595	32	CFH	CFH	NNP
cord-006702-ekf6mja9	595	33	autoantibodies	autoantibody	NNS
cord-006702-ekf6mja9	595	34	(	(	-LRB-
cord-006702-ekf6mja9	595	35	Fig	Fig	NNP
cord-006702-ekf6mja9	595	36	1	1	CD
cord-006702-ekf6mja9	595	37	)	)	-RRB-
cord-006702-ekf6mja9	595	38	.	.	.
cord-006702-ekf6mja9	596	1	For	for	IN
cord-006702-ekf6mja9	596	2	pts	pt	NNS
cord-006702-ekf6mja9	596	3	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	596	4	since	since	IN
cord-006702-ekf6mja9	596	5	2011	2011	CD
cord-006702-ekf6mja9	596	6	,	,	,
cord-006702-ekf6mja9	596	7	renal	renal	JJ
cord-006702-ekf6mja9	596	8	,	,	,
cord-006702-ekf6mja9	596	9	gastrointestinal	gastrointestinal	JJ
cord-006702-ekf6mja9	596	10	,	,	,
cord-006702-ekf6mja9	596	11	cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	596	12	,	,	,
cord-006702-ekf6mja9	596	13	central	central	JJ
cord-006702-ekf6mja9	596	14	nervous	nervous	JJ
cord-006702-ekf6mja9	596	15	system	system	NN
cord-006702-ekf6mja9	596	16	and	and	CC
cord-006702-ekf6mja9	596	17	pulmonary	pulmonary	JJ
cord-006702-ekf6mja9	596	18	TMA	TMA	NNP
cord-006702-ekf6mja9	596	19	manifestations	manifestation	NNS
cord-006702-ekf6mja9	596	20	occurred	occur	VBD
cord-006702-ekf6mja9	596	21	in	in	IN
cord-006702-ekf6mja9	596	22	the	the	DT
cord-006702-ekf6mja9	596	23	6	6	CD
cord-006702-ekf6mja9	596	24	months	month	NNS
cord-006702-ekf6mja9	596	25	prior	prior	RB
cord-006702-ekf6mja9	596	26	to	to	IN
cord-006702-ekf6mja9	596	27	baseline	baseline	NN
cord-006702-ekf6mja9	596	28	in	in	IN
cord-006702-ekf6mja9	596	29	143	143	CD
cord-006702-ekf6mja9	596	30	(	(	-LRB-
cord-006702-ekf6mja9	596	31	68	68	CD
cord-006702-ekf6mja9	596	32	%	%	NN
cord-006702-ekf6mja9	596	33	)	)	-RRB-
cord-006702-ekf6mja9	596	34	,	,	,
cord-006702-ekf6mja9	596	35	80	80	CD
cord-006702-ekf6mja9	596	36	(	(	-LRB-
cord-006702-ekf6mja9	596	37	38	38	CD
cord-006702-ekf6mja9	596	38	%	%	NN
cord-006702-ekf6mja9	596	39	)	)	-RRB-
cord-006702-ekf6mja9	596	40	,	,	,
cord-006702-ekf6mja9	596	41	60	60	CD
cord-006702-ekf6mja9	596	42	(	(	-LRB-
cord-006702-ekf6mja9	596	43	28	28	CD
cord-006702-ekf6mja9	596	44	%	%	NN
cord-006702-ekf6mja9	596	45	)	)	-RRB-
cord-006702-ekf6mja9	596	46	,	,	,
cord-006702-ekf6mja9	596	47	45	45	CD
cord-006702-ekf6mja9	596	48	(	(	-LRB-
cord-006702-ekf6mja9	596	49	21	21	CD
cord-006702-ekf6mja9	596	50	%	%	NN
cord-006702-ekf6mja9	596	51	)	)	-RRB-
cord-006702-ekf6mja9	596	52	and	and	CC
cord-006702-ekf6mja9	596	53	24	24	CD
cord-006702-ekf6mja9	596	54	(	(	-LRB-
cord-006702-ekf6mja9	596	55	11	11	CD
cord-006702-ekf6mja9	596	56	%	%	NN
cord-006702-ekf6mja9	596	57	)	)	-RRB-
cord-006702-ekf6mja9	596	58	paediatric	paediatric	JJ
cord-006702-ekf6mja9	596	59	pts	pt	NNS
cord-006702-ekf6mja9	596	60	,	,	,
cord-006702-ekf6mja9	596	61	respectively	respectively	RB
cord-006702-ekf6mja9	596	62	and	and	CC
cord-006702-ekf6mja9	596	63	were	be	VBD
cord-006702-ekf6mja9	596	64	least	least	JJS
cord-006702-ekf6mja9	596	65	common	common	JJ
cord-006702-ekf6mja9	596	66	in	in	IN
cord-006702-ekf6mja9	596	67	pts	pts	NN
cord-006702-ekf6mja9	596	68	with	with	IN
cord-006702-ekf6mja9	596	69	MCP	MCP	NNP
cord-006702-ekf6mja9	596	70	mutations	mutation	NNS
cord-006702-ekf6mja9	596	71	.	.	.
cord-006702-ekf6mja9	597	1	Five	five	CD
cord-006702-ekf6mja9	597	2	years	year	NNS
cord-006702-ekf6mja9	597	3	after	after	IN
cord-006702-ekf6mja9	597	4	disease	disease	NN
cord-006702-ekf6mja9	597	5	onset	onset	NN
cord-006702-ekf6mja9	597	6	,	,	,
cord-006702-ekf6mja9	597	7	end	end	NN
cord-006702-ekf6mja9	597	8	-	-	HYPH
cord-006702-ekf6mja9	597	9	stage	stage	NN
cord-006702-ekf6mja9	597	10	renal	renal	JJ
cord-006702-ekf6mja9	597	11	disease	disease	NN
cord-006702-ekf6mja9	597	12	(	(	-LRB-
cord-006702-ekf6mja9	597	13	ESRD	ESRD	NNP
cord-006702-ekf6mja9	597	14	)	)	-RRB-
cord-006702-ekf6mja9	597	15	had	have	VBD
cord-006702-ekf6mja9	597	16	occurred	occur	VBN
cord-006702-ekf6mja9	597	17	in	in	IN
cord-006702-ekf6mja9	597	18	26	26	CD
cord-006702-ekf6mja9	597	19	%	%	NN
cord-006702-ekf6mja9	597	20	of	of	IN
cord-006702-ekf6mja9	597	21	paediatric	paediatric	JJ
cord-006702-ekf6mja9	597	22	pts	pt	NNS
cord-006702-ekf6mja9	597	23	as	as	IN
cord-006702-ekf6mja9	597	24	compared	compare	VBN
cord-006702-ekf6mja9	597	25	with	with	IN
cord-006702-ekf6mja9	597	26	46	46	CD
cord-006702-ekf6mja9	597	27	%	%	NN
cord-006702-ekf6mja9	597	28	of	of	IN
cord-006702-ekf6mja9	597	29	adults	adult	NNS
cord-006702-ekf6mja9	597	30	(	(	-LRB-
cord-006702-ekf6mja9	597	31	Fig	Fig	NNP
cord-006702-ekf6mja9	597	32	2	2	CD
cord-006702-ekf6mja9	597	33	)	)	-RRB-
cord-006702-ekf6mja9	597	34	.	.	.
cord-006702-ekf6mja9	598	1	Overall	overall	RB
cord-006702-ekf6mja9	598	2	,	,	,
cord-006702-ekf6mja9	598	3	incidence	incidence	NN
cord-006702-ekf6mja9	598	4	of	of	IN
cord-006702-ekf6mja9	598	5	ESRD	ESRD	NNP
cord-006702-ekf6mja9	598	6	was	be	VBD
cord-006702-ekf6mja9	598	7	not	not	RB
cord-006702-ekf6mja9	598	8	significantly	significantly	RB
cord-006702-ekf6mja9	598	9	different	different	JJ
cord-006702-ekf6mja9	598	10	in	in	IN
cord-006702-ekf6mja9	598	11	pts	pts	NN
cord-006702-ekf6mja9	598	12	with	with	IN
cord-006702-ekf6mja9	598	13	or	or	CC
cord-006702-ekf6mja9	598	14	without	without	IN
cord-006702-ekf6mja9	598	15	any	any	DT
cord-006702-ekf6mja9	598	16	identified	identify	VBN
cord-006702-ekf6mja9	598	17	mutation	mutation	NN
cord-006702-ekf6mja9	598	18	.	.	.
cord-006702-ekf6mja9	599	1	Five	five	CD
cord-006702-ekf6mja9	599	2	-	-	HYPH
cord-006702-ekf6mja9	599	3	year	year	NN
cord-006702-ekf6mja9	599	4	renal	renal	JJ
cord-006702-ekf6mja9	599	5	survival	survival	NN
cord-006702-ekf6mja9	599	6	was	be	VBD
cord-006702-ekf6mja9	599	7	43	43	CD
cord-006702-ekf6mja9	599	8	%	%	NN
cord-006702-ekf6mja9	599	9	,	,	,
cord-006702-ekf6mja9	599	10	46	46	CD
cord-006702-ekf6mja9	599	11	%	%	NN
cord-006702-ekf6mja9	599	12	,	,	,
cord-006702-ekf6mja9	599	13	57	57	CD
cord-006702-ekf6mja9	599	14	%	%	NN
cord-006702-ekf6mja9	599	15	,	,	,
cord-006702-ekf6mja9	599	16	64	64	CD
cord-006702-ekf6mja9	599	17	%	%	NN
cord-006702-ekf6mja9	599	18	and	and	CC
cord-006702-ekf6mja9	599	19	92	92	CD
cord-006702-ekf6mja9	599	20	%	%	NN
cord-006702-ekf6mja9	599	21	in	in	IN
cord-006702-ekf6mja9	599	22	pts	pt	NNS
cord-006702-ekf6mja9	599	23	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	599	24	with	with	IN
cord-006702-ekf6mja9	599	25	CFH	CFH	NNP
cord-006702-ekf6mja9	599	26	,	,	,
cord-006702-ekf6mja9	599	27	CFH	CFH	NNP
cord-006702-ekf6mja9	599	28	autoantibodies	autoantibody	NNS
cord-006702-ekf6mja9	599	29	,	,	,
cord-006702-ekf6mja9	599	30	C3	C3	NNP
cord-006702-ekf6mja9	599	31	,	,	,
cord-006702-ekf6mja9	599	32	CFI	CFI	NNP
cord-006702-ekf6mja9	599	33	and	and	CC
cord-006702-ekf6mja9	599	34	MCP	MCP	NNP
cord-006702-ekf6mja9	599	35	mutations	mutation	NNS
cord-006702-ekf6mja9	599	36	,	,	,
cord-006702-ekf6mja9	599	37	respectively	respectively	RB
cord-006702-ekf6mja9	599	38	,	,	,
cord-006702-ekf6mja9	599	39	and	and	CC
cord-006702-ekf6mja9	599	40	65	65	CD
cord-006702-ekf6mja9	599	41	%	%	NN
cord-006702-ekf6mja9	599	42	in	in	IN
cord-006702-ekf6mja9	599	43	pts	pt	NNS
cord-006702-ekf6mja9	599	44	with	with	IN
cord-006702-ekf6mja9	599	45	no	no	DT
cord-006702-ekf6mja9	599	46	identified	identify	VBN
cord-006702-ekf6mja9	599	47	complement	complement	JJ
cord-006702-ekf6mja9	599	48	abnormality	abnormality	NN
cord-006702-ekf6mja9	599	49	.	.	.
cord-006702-ekf6mja9	600	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	600	2	:	:	:
cord-006702-ekf6mja9	601	1	We	-PRON-	PRP
cord-006702-ekf6mja9	601	2	describe	describe	VBP
cord-006702-ekf6mja9	601	3	the	the	DT
cord-006702-ekf6mja9	601	4	phenotype	phenotype	NN
cord-006702-ekf6mja9	601	5	and	and	CC
cord-006702-ekf6mja9	601	6	natural	natural	JJ
cord-006702-ekf6mja9	601	7	history	history	NN
cord-006702-ekf6mja9	601	8	of	of	IN
cord-006702-ekf6mja9	601	9	aHUS	ahus	DT
cord-006702-ekf6mja9	602	1	in	in	IN
cord-006702-ekf6mja9	602	2	the	the	DT
cord-006702-ekf6mja9	602	3	largest	large	JJS
cord-006702-ekf6mja9	602	4	cohort	cohort	NN
cord-006702-ekf6mja9	602	5	of	of	IN
cord-006702-ekf6mja9	602	6	pts	pts	NN
cord-006702-ekf6mja9	602	7	to	to	IN
cord-006702-ekf6mja9	602	8	date	date	NN
cord-006702-ekf6mja9	602	9	,	,	,
cord-006702-ekf6mja9	602	10	which	which	WDT
cord-006702-ekf6mja9	602	11	includes	include	VBZ
cord-006702-ekf6mja9	602	12	pts	pts	NN
cord-006702-ekf6mja9	602	13	of	of	IN
cord-006702-ekf6mja9	602	14	all	all	DT
cord-006702-ekf6mja9	602	15	ages	age	NNS
cord-006702-ekf6mja9	602	16	.	.	.
cord-006702-ekf6mja9	603	1	This	this	DT
cord-006702-ekf6mja9	603	2	is	be	VBZ
cord-006702-ekf6mja9	603	3	the	the	DT
cord-006702-ekf6mja9	603	4	first	first	JJ
cord-006702-ekf6mja9	603	5	report	report	NN
cord-006702-ekf6mja9	603	6	to	to	TO
cord-006702-ekf6mja9	603	7	show	show	VB
cord-006702-ekf6mja9	603	8	extra	extra	JJ
cord-006702-ekf6mja9	603	9	-	-	JJ
cord-006702-ekf6mja9	603	10	renal	renal	JJ
cord-006702-ekf6mja9	603	11	manifestations	manifestation	NNS
cord-006702-ekf6mja9	603	12	occur	occur	VBP
cord-006702-ekf6mja9	603	13	in	in	IN
cord-006702-ekf6mja9	603	14	>	>	$
cord-006702-ekf6mja9	603	15	30	30	CD
cord-006702-ekf6mja9	603	16	%	%	NN
cord-006702-ekf6mja9	603	17	of	of	IN
cord-006702-ekf6mja9	603	18	paediatric	paediatric	JJ
cord-006702-ekf6mja9	603	19	patients	patient	NNS
cord-006702-ekf6mja9	603	20	and	and	CC
cord-006702-ekf6mja9	603	21	that	that	IN
cord-006702-ekf6mja9	603	22	pts	pts	NN
cord-006702-ekf6mja9	603	23	with	with	IN
cord-006702-ekf6mja9	603	24	CFI	CFI	NNP
cord-006702-ekf6mja9	603	25	mutations	mutation	NNS
cord-006702-ekf6mja9	603	26	have	have	VBP
cord-006702-ekf6mja9	603	27	later	later	JJ
cord-006702-ekf6mja9	603	28	onset	onset	NN
cord-006702-ekf6mja9	603	29	of	of	IN
cord-006702-ekf6mja9	603	30	aHUS	ahus	DT
cord-006702-ekf6mja9	603	31	compared	compare	VBN
cord-006702-ekf6mja9	603	32	with	with	IN
cord-006702-ekf6mja9	603	33	other	other	JJ
cord-006702-ekf6mja9	603	34	complement	complement	NN
cord-006702-ekf6mja9	603	35	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	603	36	.	.	.
cord-006702-ekf6mja9	604	1	ESRD	ESRD	NNP
cord-006702-ekf6mja9	604	2	occurred	occur	VBD
cord-006702-ekf6mja9	604	3	significantly	significantly	RB
cord-006702-ekf6mja9	604	4	less	less	RBR
cord-006702-ekf6mja9	604	5	frequently	frequently	RB
cord-006702-ekf6mja9	604	6	in	in	IN
cord-006702-ekf6mja9	604	7	pts	pts	NN
cord-006702-ekf6mja9	604	8	with	with	IN
cord-006702-ekf6mja9	604	9	childhood	childhood	NN
cord-006702-ekf6mja9	604	10	compared	compare	VBN
cord-006702-ekf6mja9	604	11	with	with	IN
cord-006702-ekf6mja9	604	12	adult	adult	NN
cord-006702-ekf6mja9	604	13	-	-	HYPH
cord-006702-ekf6mja9	604	14	onset	onset	NN
cord-006702-ekf6mja9	604	15	.	.	.
cord-006702-ekf6mja9	605	1	Renal	renal	JJ
cord-006702-ekf6mja9	605	2	outcomes	outcome	NNS
cord-006702-ekf6mja9	605	3	were	be	VBD
cord-006702-ekf6mja9	605	4	most	most	RBS
cord-006702-ekf6mja9	605	5	favourable	favourable	JJ
cord-006702-ekf6mja9	605	6	in	in	IN
cord-006702-ekf6mja9	605	7	pts	pts	NN
cord-006702-ekf6mja9	605	8	with	with	IN
cord-006702-ekf6mja9	605	9	MCP	MCP	NNP
cord-006702-ekf6mja9	605	10	mutations	mutation	NNS
cord-006702-ekf6mja9	605	11	and	and	CC
cord-006702-ekf6mja9	605	12	least	least	JJS
cord-006702-ekf6mja9	605	13	favourable	favourable	JJ
cord-006702-ekf6mja9	605	14	in	in	IN
cord-006702-ekf6mja9	605	15	pts	pts	NN
cord-006702-ekf6mja9	605	16	with	with	IN
cord-006702-ekf6mja9	605	17	CFH	CFH	NNP
cord-006702-ekf6mja9	605	18	mutations	mutation	NNS
cord-006702-ekf6mja9	605	19	and	and	CC
cord-006702-ekf6mja9	605	20	CFH	CFH	NNP
cord-006702-ekf6mja9	605	21	autoantibodies	autoantibody	NNS
cord-006702-ekf6mja9	605	22	.	.	.
cord-006702-ekf6mja9	606	1	FP	FP	NNP
cord-006702-ekf6mja9	606	2	-	-	HYPH
cord-006702-ekf6mja9	606	3	S18	S18	NNP
cord-006702-ekf6mja9	606	4	-	-	HYPH
cord-006702-ekf6mja9	606	5	2	2	CD
cord-006702-ekf6mja9	606	6	Targeted	target	VBN
cord-006702-ekf6mja9	606	7	exome	exome	NN
cord-006702-ekf6mja9	606	8	sequencing	sequencing	NN
cord-006702-ekf6mja9	606	9	in	in	IN
cord-006702-ekf6mja9	606	10	patients	patient	NNS
cord-006702-ekf6mja9	606	11	with	with	IN
cord-006702-ekf6mja9	606	12	atypical	atypical	JJ
cord-006702-ekf6mja9	606	13	hemolytic	hemolytic	JJ
cord-006702-ekf6mja9	606	14	uremic	uremic	JJ
cord-006702-ekf6mja9	606	15	syndrome	syndrome	NN
cord-006702-ekf6mja9	606	16	(	(	-LRB-
cord-006702-ekf6mja9	606	17	aHUS	aHUS	NNP
cord-006702-ekf6mja9	606	18	)	)	-RRB-
cord-006702-ekf6mja9	606	19	and	and	CC
cord-006702-ekf6mja9	607	1	negative	negative	JJ
cord-006702-ekf6mja9	607	2	anti	anti	JJ
cord-006702-ekf6mja9	607	3	-	-	JJ
cord-006702-ekf6mja9	607	4	complement	complement	JJ
cord-006702-ekf6mja9	607	5	factor	factor	NN
cord-006702-ekf6mja9	607	6	H	h	NN
cord-006702-ekf6mja9	607	7	(	(	-LRB-
cord-006702-ekf6mja9	607	8	FH	FH	NNP
cord-006702-ekf6mja9	607	9	)	)	-RRB-
cord-006702-ekf6mja9	607	10	antibodies	antibody	NNS
cord-006702-ekf6mja9	607	11	reveals	reveal	VBZ
cord-006702-ekf6mja9	607	12	multiple	multiple	JJ
cord-006702-ekf6mja9	607	13	variations	variation	NNS
cord-006702-ekf6mja9	608	1	R.	R.	NNP
cord-006702-ekf6mja9	608	2	Thergaonkar	Thergaonkar	NNP
cord-006702-ekf6mja9	608	3	(	(	-LRB-
cord-006702-ekf6mja9	608	4	1	1	CD
cord-006702-ekf6mja9	608	5	)	)	-RRB-
cord-006702-ekf6mja9	608	6	,	,	,
cord-006702-ekf6mja9	608	7	A.	A.	NNP
cord-006702-ekf6mja9	608	8	Narang	Narang	NNP
cord-006702-ekf6mja9	608	9	(	(	-LRB-
cord-006702-ekf6mja9	608	10	2	2	CD
cord-006702-ekf6mja9	608	11	)	)	-RRB-
cord-006702-ekf6mja9	608	12	&	&	CC
cord-006702-ekf6mja9	608	13	Figure	figure	NN
cord-006702-ekf6mja9	608	14	1	1	CD
cord-006702-ekf6mja9	608	15	:	:	:
cord-006702-ekf6mja9	608	16	Distribution	distribution	NN
cord-006702-ekf6mja9	608	17	of	of	IN
cord-006702-ekf6mja9	608	18	variants	variant	NNS
cord-006702-ekf6mja9	608	19	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	608	20	:	:	:
cord-006702-ekf6mja9	608	21	Genetic	genetic	JJ
cord-006702-ekf6mja9	608	22	susceptibility	susceptibility	NN
cord-006702-ekf6mja9	608	23	in	in	IN
cord-006702-ekf6mja9	608	24	anti	anti	JJ
cord-006702-ekf6mja9	608	25	-	-	JJ
cord-006702-ekf6mja9	608	26	FH	FH	NNP
cord-006702-ekf6mja9	608	27	antibody	antibody	NN
cord-006702-ekf6mja9	608	28	negative	negative	JJ
cord-006702-ekf6mja9	608	29	aHUS	ahus	DT
cord-006702-ekf6mja9	608	30	is	be	VBZ
cord-006702-ekf6mja9	608	31	complex	complex	JJ
cord-006702-ekf6mja9	608	32	.	.	.
cord-006702-ekf6mja9	609	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	609	2	scheme	scheme	NN
cord-006702-ekf6mja9	609	3	of	of	IN
cord-006702-ekf6mja9	609	4	prioritization	prioritization	NN
cord-006702-ekf6mja9	609	5	was	be	VBD
cord-006702-ekf6mja9	609	6	useful	useful	JJ
cord-006702-ekf6mja9	609	7	in	in	IN
cord-006702-ekf6mja9	609	8	identification	identification	NN
cord-006702-ekf6mja9	609	9	of	of	IN
cord-006702-ekf6mja9	609	10	diagnostic	diagnostic	JJ
cord-006702-ekf6mja9	609	11	as	as	RB
cord-006702-ekf6mja9	609	12	well	well	RB
cord-006702-ekf6mja9	609	13	as	as	IN
cord-006702-ekf6mja9	609	14	background	background	NN
cord-006702-ekf6mja9	609	15	genetic	genetic	JJ
cord-006702-ekf6mja9	609	16	variation	variation	NN
cord-006702-ekf6mja9	609	17	.	.	.
cord-006702-ekf6mja9	610	1	FP	FP	NNP
cord-006702-ekf6mja9	610	2	-	-	HYPH
cord-006702-ekf6mja9	610	3	S18	S18	NNP
cord-006702-ekf6mja9	610	4	-	-	HYPH
cord-006702-ekf6mja9	610	5	3	3	CD
cord-006702-ekf6mja9	610	6	Predictors	Predictors	NNP
cord-006702-ekf6mja9	610	7	of	of	IN
cord-006702-ekf6mja9	610	8	poor	poor	JJ
cord-006702-ekf6mja9	610	9	long	long	JJ
cord-006702-ekf6mja9	610	10	-	-	HYPH
cord-006702-ekf6mja9	610	11	term	term	NN
cord-006702-ekf6mja9	610	12	renal	renal	JJ
cord-006702-ekf6mja9	610	13	prognosis	prognosis	NN
cord-006702-ekf6mja9	610	14	in	in	IN
cord-006702-ekf6mja9	610	15	children	child	NNS
cord-006702-ekf6mja9	610	16	with	with	IN
cord-006702-ekf6mja9	610	17	Hemolytic	hemolytic	JJ
cord-006702-ekf6mja9	610	18	Uremic	Uremic	NNP
cord-006702-ekf6mja9	610	19	Syndrome	Syndrome	NNP
cord-006702-ekf6mja9	610	20	L.	L.	NNP
cord-006702-ekf6mja9	610	21	Alconcher	Alconcher	NNP
cord-006702-ekf6mja9	610	22	(	(	-LRB-
cord-006702-ekf6mja9	610	23	1	1	CD
cord-006702-ekf6mja9	610	24	)	)	-RRB-
cord-006702-ekf6mja9	610	25	,	,	,
cord-006702-ekf6mja9	610	26	L.	L.	NNP
cord-006702-ekf6mja9	610	27	Lucarelli	Lucarelli	NNP
cord-006702-ekf6mja9	610	28	(	(	-LRB-
cord-006702-ekf6mja9	610	29	1	1	CD
cord-006702-ekf6mja9	610	30	)	)	-RRB-
cord-006702-ekf6mja9	610	31	,	,	,
cord-006702-ekf6mja9	610	32	M.	M.	NNP
cord-006702-ekf6mja9	610	33	Rivero	Rivero	NNP
cord-006702-ekf6mja9	610	34	(	(	-LRB-
cord-006702-ekf6mja9	610	35	2	2	CD
cord-006702-ekf6mja9	610	36	)	)	-RRB-
cord-006702-ekf6mja9	610	37	,	,	,
cord-006702-ekf6mja9	610	38	E.	E.	NNP
cord-006702-ekf6mja9	610	39	Rodriguez	Rodriguez	NNP
cord-006702-ekf6mja9	610	40	(	(	-LRB-
cord-006702-ekf6mja9	610	41	2	2	LS
cord-006702-ekf6mja9	610	42	)	)	-RRB-
cord-006702-ekf6mja9	610	43	(	(	-LRB-
cord-006702-ekf6mja9	610	44	1	1	CD
cord-006702-ekf6mja9	610	45	)	)	-RRB-
cord-006702-ekf6mja9	611	1	Hospital	Hospital	NNP
cord-006702-ekf6mja9	611	2	Interzonal	Interzonal	NNP
cord-006702-ekf6mja9	611	3	Dr.	Dr.	NNP
cord-006702-ekf6mja9	611	4	Jose	Jose	NNP
cord-006702-ekf6mja9	611	5	Penna	Penna	NNP
cord-006702-ekf6mja9	611	6	,	,	,
cord-006702-ekf6mja9	611	7	Bahia	Bahia	NNP
cord-006702-ekf6mja9	611	8	Blanca	Blanca	NNP
cord-006702-ekf6mja9	611	9	,	,	,
cord-006702-ekf6mja9	611	10	Argentina	Argentina	NNP
cord-006702-ekf6mja9	611	11	;	;	:
cord-006702-ekf6mja9	611	12	(	(	-LRB-
cord-006702-ekf6mja9	611	13	2	2	LS
cord-006702-ekf6mja9	611	14	)	)	-RRB-
cord-006702-ekf6mja9	612	1	Universidad	Universidad	NNP
cord-006702-ekf6mja9	612	2	Nacional	Nacional	NNP
cord-006702-ekf6mja9	612	3	del	del	NNP
cord-006702-ekf6mja9	612	4	Centro	Centro	NNP
cord-006702-ekf6mja9	612	5	de	de	FW
cord-006702-ekf6mja9	612	6	la	la	NNP
cord-006702-ekf6mja9	612	7	Provincia	Provincia	NNP
cord-006702-ekf6mja9	612	8	de	de	FW
cord-006702-ekf6mja9	612	9	Buenos	Buenos	NNP
cord-006702-ekf6mja9	612	10	Aires	Aires	NNP
cord-006702-ekf6mja9	612	11	,	,	,
cord-006702-ekf6mja9	612	12	Tandil	Tandil	NNP
cord-006702-ekf6mja9	612	13	,	,	,
cord-006702-ekf6mja9	612	14	Argentina	Argentina	NNP
cord-006702-ekf6mja9	612	15	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	612	16	:	:	:
cord-006702-ekf6mja9	612	17	Approximately	approximately	RB
cord-006702-ekf6mja9	612	18	50	50	CD
cord-006702-ekf6mja9	612	19	%	%	NN
cord-006702-ekf6mja9	612	20	of	of	IN
cord-006702-ekf6mja9	612	21	hemolytic	hemolytic	JJ
cord-006702-ekf6mja9	612	22	uremic	uremic	JJ
cord-006702-ekf6mja9	612	23	syndrome	syndrome	NN
cord-006702-ekf6mja9	612	24	(	(	-LRB-
cord-006702-ekf6mja9	612	25	HUS	HUS	NNP
cord-006702-ekf6mja9	612	26	)	)	-RRB-
cord-006702-ekf6mja9	612	27	patients	patient	NNS
cord-006702-ekf6mja9	612	28	evolved	evolve	VBD
cord-006702-ekf6mja9	612	29	to	to	IN
cord-006702-ekf6mja9	612	30	different	different	JJ
cord-006702-ekf6mja9	612	31	stages	stage	NNS
cord-006702-ekf6mja9	612	32	of	of	IN
cord-006702-ekf6mja9	612	33	chronic	chronic	JJ
cord-006702-ekf6mja9	612	34	kidney	kidney	NN
cord-006702-ekf6mja9	612	35	disease	disease	NN
cord-006702-ekf6mja9	612	36	(	(	-LRB-
cord-006702-ekf6mja9	612	37	CKD	CKD	NNP
cord-006702-ekf6mja9	612	38	)	)	-RRB-
cord-006702-ekf6mja9	612	39	.	.	.
cord-006702-ekf6mja9	613	1	More	More	JJR
cord-006702-ekf6mja9	613	2	days	day	NNS
cord-006702-ekf6mja9	613	3	of	of	IN
cord-006702-ekf6mja9	613	4	anuria	anuria	NNP
cord-006702-ekf6mja9	613	5	imply	imply	VBP
cord-006702-ekf6mja9	613	6	a	a	DT
cord-006702-ekf6mja9	613	7	worse	bad	JJR
cord-006702-ekf6mja9	613	8	long	long	JJ
cord-006702-ekf6mja9	613	9	term	term	NN
cord-006702-ekf6mja9	613	10	renal	renal	JJ
cord-006702-ekf6mja9	613	11	prognosis	prognosis	NN
cord-006702-ekf6mja9	613	12	.	.	.
cord-006702-ekf6mja9	614	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	614	2	aim	aim	NN
cord-006702-ekf6mja9	614	3	was	be	VBD
cord-006702-ekf6mja9	614	4	to	to	TO
cord-006702-ekf6mja9	614	5	look	look	VB
cord-006702-ekf6mja9	614	6	for	for	IN
cord-006702-ekf6mja9	614	7	predictors	predictor	NNS
cord-006702-ekf6mja9	614	8	of	of	IN
cord-006702-ekf6mja9	614	9	poor	poor	JJ
cord-006702-ekf6mja9	614	10	renal	renal	JJ
cord-006702-ekf6mja9	614	11	outcome	outcome	NN
cord-006702-ekf6mja9	614	12	.	.	.
cord-006702-ekf6mja9	615	1	Methods	method	NNS
cord-006702-ekf6mja9	615	2	:	:	:
cord-006702-ekf6mja9	615	3	Observational	observational	JJ
cord-006702-ekf6mja9	615	4	,	,	,
cord-006702-ekf6mja9	615	5	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	615	6	and	and	CC
cord-006702-ekf6mja9	615	7	retro	retro	JJ
cord-006702-ekf6mja9	615	8	-	-	HYPH
cord-006702-ekf6mja9	615	9	prospective	prospective	JJ
cord-006702-ekf6mja9	615	10	study	study	NN
cord-006702-ekf6mja9	615	11	.	.	.
cord-006702-ekf6mja9	616	1	Postdiarrheal	postdiarrheal	NN
cord-006702-ekf6mja9	616	2	HUS	HUS	NNP
cord-006702-ekf6mja9	616	3	patients	patient	NNS
cord-006702-ekf6mja9	616	4	with	with	IN
cord-006702-ekf6mja9	616	5	at	at	RB
cord-006702-ekf6mja9	616	6	least	least	JJS
cord-006702-ekf6mja9	616	7	5	5	CD
cord-006702-ekf6mja9	616	8	years	year	NNS
cord-006702-ekf6mja9	616	9	of	of	IN
cord-006702-ekf6mja9	616	10	follow	follow	NN
cord-006702-ekf6mja9	616	11	-	-	HYPH
cord-006702-ekf6mja9	616	12	up	up	NN
cord-006702-ekf6mja9	616	13	were	be	VBD
cord-006702-ekf6mja9	616	14	included	include	VBN
cord-006702-ekf6mja9	616	15	.	.	.
cord-006702-ekf6mja9	617	1	To	to	TO
cord-006702-ekf6mja9	617	2	evaluate	evaluate	VB
cord-006702-ekf6mja9	617	3	long	long	JJ
cord-006702-ekf6mja9	617	4	term	term	NN
cord-006702-ekf6mja9	617	5	renal	renal	JJ
cord-006702-ekf6mja9	617	6	outcome	outcome	NN
cord-006702-ekf6mja9	617	7	,	,	,
cord-006702-ekf6mja9	617	8	patients	patient	NNS
cord-006702-ekf6mja9	617	9	were	be	VBD
cord-006702-ekf6mja9	617	10	divided	divide	VBN
cord-006702-ekf6mja9	617	11	in	in	IN
cord-006702-ekf6mja9	617	12	3	3	CD
cord-006702-ekf6mja9	617	13	groups	group	NNS
cord-006702-ekf6mja9	617	14	:	:	:
cord-006702-ekf6mja9	618	1	No	no	DT
cord-006702-ekf6mja9	618	2	sequelae	sequela	NNS
cord-006702-ekf6mja9	618	3	,	,	,
cord-006702-ekf6mja9	618	4	CKD	CKD	NNP
cord-006702-ekf6mja9	618	5	stage	stage	NN
cord-006702-ekf6mja9	618	6	1	1	CD
cord-006702-ekf6mja9	618	7	and	and	CC
cord-006702-ekf6mja9	618	8	CKD	CKD	NNP
cord-006702-ekf6mja9	618	9	stage	stage	NN
cord-006702-ekf6mja9	618	10	2	2	CD
cord-006702-ekf6mja9	618	11	-	-	SYM
cord-006702-ekf6mja9	618	12	5	5	CD
cord-006702-ekf6mja9	618	13	.	.	.
cord-006702-ekf6mja9	619	1	Predictors	predictor	NNS
cord-006702-ekf6mja9	619	2	analyzed	analyze	VBD
cord-006702-ekf6mja9	619	3	included	include	VBD
cord-006702-ekf6mja9	619	4	:	:	:
cord-006702-ekf6mja9	619	5	gender	gender	NN
cord-006702-ekf6mja9	619	6	,	,	,
cord-006702-ekf6mja9	619	7	age	age	NN
cord-006702-ekf6mja9	619	8	at	at	IN
cord-006702-ekf6mja9	619	9	onset	onset	NN
cord-006702-ekf6mja9	619	10	(	(	-LRB-
cord-006702-ekf6mja9	619	11	<	<	NNP
cord-006702-ekf6mja9	619	12	1	1	CD
cord-006702-ekf6mja9	619	13	,	,	,
cord-006702-ekf6mja9	619	14	1	1	CD
cord-006702-ekf6mja9	619	15	-	-	SYM
cord-006702-ekf6mja9	619	16	2	2	CD
cord-006702-ekf6mja9	619	17	,	,	,
cord-006702-ekf6mja9	619	18	≥	≥	CD
cord-006702-ekf6mja9	619	19	2	2	CD
cord-006702-ekf6mja9	619	20	years	year	NNS
cord-006702-ekf6mja9	619	21	)	)	-RRB-
cord-006702-ekf6mja9	619	22	,	,	,
cord-006702-ekf6mja9	619	23	neurological	neurological	JJ
cord-006702-ekf6mja9	619	24	involvement	involvement	NN
cord-006702-ekf6mja9	619	25	(	(	-LRB-
cord-006702-ekf6mja9	619	26	seizures	seizure	NNS
cord-006702-ekf6mja9	619	27	and/or	and/or	CC
cord-006702-ekf6mja9	619	28	coma	coma	NN
cord-006702-ekf6mja9	619	29	)	)	-RRB-
cord-006702-ekf6mja9	619	30	,	,	,
cord-006702-ekf6mja9	619	31	maximum	maximum	JJ
cord-006702-ekf6mja9	619	32	white	white	JJ
cord-006702-ekf6mja9	619	33	blood	blood	NN
cord-006702-ekf6mja9	619	34	cells	cell	NNS
cord-006702-ekf6mja9	619	35	(	(	-LRB-
cord-006702-ekf6mja9	619	36	WBC	WBC	NNP
cord-006702-ekf6mja9	619	37	)	)	-RRB-
cord-006702-ekf6mja9	619	38	counts	count	VBZ
cord-006702-ekf6mja9	619	39	(	(	-LRB-
cord-006702-ekf6mja9	620	1	≤20000	≤20000	NNP
cord-006702-ekf6mja9	620	2	or	or	CC
cord-006702-ekf6mja9	620	3	>	>	XX
cord-006702-ekf6mja9	620	4	20000	20000	CD
cord-006702-ekf6mja9	620	5	)	)	-RRB-
cord-006702-ekf6mja9	620	6	,	,	,
cord-006702-ekf6mja9	620	7	days	day	NNS
cord-006702-ekf6mja9	620	8	of	of	IN
cord-006702-ekf6mja9	620	9	dialysis	dialysis	NN
cord-006702-ekf6mja9	620	10	(	(	-LRB-
cord-006702-ekf6mja9	620	11	0	0	CD
cord-006702-ekf6mja9	620	12	,	,	,
cord-006702-ekf6mja9	620	13	1	1	CD
cord-006702-ekf6mja9	620	14	-	-	SYM
cord-006702-ekf6mja9	620	15	9	9	CD
cord-006702-ekf6mja9	620	16	and	and	CC
cord-006702-ekf6mja9	620	17	≥10	≥10	NNP
cord-006702-ekf6mja9	620	18	)	)	-RRB-
cord-006702-ekf6mja9	620	19	,	,	,
cord-006702-ekf6mja9	620	20	initial	initial	JJ
cord-006702-ekf6mja9	620	21	hematocrit	hematocrit	NN
cord-006702-ekf6mja9	620	22	(	(	-LRB-
cord-006702-ekf6mja9	620	23	≤23	≤23	NNS
cord-006702-ekf6mja9	620	24	or	or	CC
cord-006702-ekf6mja9	620	25	>	>	XX
cord-006702-ekf6mja9	620	26	23	23	CD
cord-006702-ekf6mja9	620	27	%	%	NN
cord-006702-ekf6mja9	620	28	)	)	-RRB-
cord-006702-ekf6mja9	620	29	,	,	,
cord-006702-ekf6mja9	620	30	and	and	CC
cord-006702-ekf6mja9	620	31	red	red	JJ
cord-006702-ekf6mja9	620	32	blood	blood	NN
cord-006702-ekf6mja9	620	33	cells	cell	NNS
cord-006702-ekf6mja9	620	34	(	(	-LRB-
cord-006702-ekf6mja9	620	35	RBC	RBC	NNP
cord-006702-ekf6mja9	620	36	)	)	-RRB-
cord-006702-ekf6mja9	620	37	transfusion	transfusion	NN
cord-006702-ekf6mja9	620	38	requirement	requirement	NN
cord-006702-ekf6mja9	620	39	.	.	.
cord-006702-ekf6mja9	621	1	A	a	DT
cord-006702-ekf6mja9	621	2	bivariate	bivariate	JJ
cord-006702-ekf6mja9	621	3	and	and	CC
cord-006702-ekf6mja9	621	4	multivariate	multivariate	JJ
cord-006702-ekf6mja9	621	5	analysis	analysis	NN
cord-006702-ekf6mja9	621	6	were	be	VBD
cord-006702-ekf6mja9	621	7	performed	perform	VBN
cord-006702-ekf6mja9	621	8	,	,	,
cord-006702-ekf6mja9	621	9	a	a	DT
cord-006702-ekf6mja9	621	10	p<0.05	p<0.05	NN
cord-006702-ekf6mja9	621	11	was	be	VBD
cord-006702-ekf6mja9	621	12	considered	consider	VBN
cord-006702-ekf6mja9	621	13	significant	significant	JJ
cord-006702-ekf6mja9	621	14	.	.	.
cord-006702-ekf6mja9	622	1	Results	result	NNS
cord-006702-ekf6mja9	622	2	:	:	:
cord-006702-ekf6mja9	622	3	180	180	CD
cord-006702-ekf6mja9	622	4	patients	patient	NNS
cord-006702-ekf6mja9	622	5	(	(	-LRB-
cord-006702-ekf6mja9	622	6	91	91	CD
cord-006702-ekf6mja9	622	7	males	male	NNS
cord-006702-ekf6mja9	622	8	)	)	-RRB-
cord-006702-ekf6mja9	622	9	with	with	IN
cord-006702-ekf6mja9	622	10	a	a	DT
cord-006702-ekf6mja9	622	11	median	median	JJ
cord-006702-ekf6mja9	622	12	follow	follow	NN
cord-006702-ekf6mja9	622	13	-	-	HYPH
cord-006702-ekf6mja9	622	14	up	up	NN
cord-006702-ekf6mja9	622	15	of	of	IN
cord-006702-ekf6mja9	622	16	11.9	11.9	CD
cord-006702-ekf6mja9	622	17	years	year	NNS
cord-006702-ekf6mja9	622	18	were	be	VBD
cord-006702-ekf6mja9	622	19	included	include	VBN
cord-006702-ekf6mja9	622	20	.	.	.
cord-006702-ekf6mja9	623	1	Gender	gender	NN
cord-006702-ekf6mja9	623	2	,	,	,
cord-006702-ekf6mja9	623	3	age	age	NN
cord-006702-ekf6mja9	623	4	at	at	IN
cord-006702-ekf6mja9	623	5	onset	onset	NN
cord-006702-ekf6mja9	623	6	and	and	CC
cord-006702-ekf6mja9	623	7	neurological	neurological	JJ
cord-006702-ekf6mja9	623	8	involvement	involvement	NN
cord-006702-ekf6mja9	623	9	were	be	VBD
cord-006702-ekf6mja9	623	10	not	not	RB
cord-006702-ekf6mja9	623	11	associated	associate	VBN
cord-006702-ekf6mja9	623	12	with	with	IN
cord-006702-ekf6mja9	623	13	long	long	JJ
cord-006702-ekf6mja9	623	14	term	term	NN
cord-006702-ekf6mja9	623	15	renal	renal	JJ
cord-006702-ekf6mja9	623	16	outcome	outcome	NN
cord-006702-ekf6mja9	623	17	.	.	.
cord-006702-ekf6mja9	624	1	WBC	WBC	NNP
cord-006702-ekf6mja9	624	2	count	count	NN
cord-006702-ekf6mja9	624	3	>	>	XX
cord-006702-ekf6mja9	625	1	20000	20000	CD
cord-006702-ekf6mja9	625	2	and	and	CC
cord-006702-ekf6mja9	625	3	hematocrit	hematocrit	NN
cord-006702-ekf6mja9	625	4	>	>	XX
cord-006702-ekf6mja9	625	5	23	23	CD
cord-006702-ekf6mja9	625	6	%	%	NN
cord-006702-ekf6mja9	625	7	were	be	VBD
cord-006702-ekf6mja9	625	8	significant	significant	JJ
cord-006702-ekf6mja9	625	9	CKD	CKD	NNP
cord-006702-ekf6mja9	625	10	predictors	predictor	NNS
cord-006702-ekf6mja9	625	11	only	only	RB
cord-006702-ekf6mja9	625	12	in	in	IN
cord-006702-ekf6mja9	625	13	the	the	DT
cord-006702-ekf6mja9	625	14	bivariate	bivariate	JJ
cord-006702-ekf6mja9	625	15	analysis	analysis	NN
cord-006702-ekf6mja9	625	16	(	(	-LRB-
cord-006702-ekf6mja9	625	17	p=0.04	p=0.04	NNP
cord-006702-ekf6mja9	625	18	and	and	CC
cord-006702-ekf6mja9	625	19	0.0049	0.0049	CD
cord-006702-ekf6mja9	625	20	)	)	-RRB-
cord-006702-ekf6mja9	625	21	.	.	.
cord-006702-ekf6mja9	626	1	The	the	DT
cord-006702-ekf6mja9	626	2	risk	risk	NN
cord-006702-ekf6mja9	626	3	to	to	TO
cord-006702-ekf6mja9	626	4	evolve	evolve	VB
cord-006702-ekf6mja9	626	5	to	to	IN
cord-006702-ekf6mja9	626	6	CKD	CKD	NNP
cord-006702-ekf6mja9	626	7	stages	stage	NNS
cord-006702-ekf6mja9	627	1	2	2	LS
cord-006702-ekf6mja9	627	2	-	-	SYM
cord-006702-ekf6mja9	627	3	5	5	CD
cord-006702-ekf6mja9	627	4	in	in	IN
cord-006702-ekf6mja9	627	5	patients	patient	NNS
cord-006702-ekf6mja9	627	6	who	who	WP
cord-006702-ekf6mja9	627	7	did	do	VBD
cord-006702-ekf6mja9	627	8	not	not	RB
cord-006702-ekf6mja9	627	9	require	require	VB
cord-006702-ekf6mja9	627	10	dialysis	dialysis	NN
cord-006702-ekf6mja9	627	11	was	be	VBD
cord-006702-ekf6mja9	627	12	similar	similar	JJ
cord-006702-ekf6mja9	627	13	to	to	IN
cord-006702-ekf6mja9	627	14	those	those	DT
cord-006702-ekf6mja9	627	15	with	with	IN
cord-006702-ekf6mja9	627	16	<	<	NNP
cord-006702-ekf6mja9	627	17	10	10	CD
cord-006702-ekf6mja9	627	18	days	day	NNS
cord-006702-ekf6mja9	627	19	(	(	-LRB-
cord-006702-ekf6mja9	627	20	p=0.31	p=0.31	NNP
cord-006702-ekf6mja9	627	21	)	)	-RRB-
cord-006702-ekf6mja9	627	22	.	.	.
cord-006702-ekf6mja9	628	1	CKD	CKD	NNP
cord-006702-ekf6mja9	628	2	risk	risk	NN
cord-006702-ekf6mja9	628	3	increased	increase	VBD
cord-006702-ekf6mja9	628	4	8.8	8.8	CD
cord-006702-ekf6mja9	628	5	and	and	CC
cord-006702-ekf6mja9	628	6	3.2	3.2	CD
cord-006702-ekf6mja9	628	7	times	time	NNS
cord-006702-ekf6mja9	628	8	in	in	IN
cord-006702-ekf6mja9	628	9	patients	patient	NNS
cord-006702-ekf6mja9	628	10	with	with	IN
cord-006702-ekf6mja9	628	11	≥	≥	CD
cord-006702-ekf6mja9	628	12	10	10	CD
cord-006702-ekf6mja9	628	13	days	day	NNS
cord-006702-ekf6mja9	628	14	of	of	IN
cord-006702-ekf6mja9	628	15	dialysis	dialysis	NN
cord-006702-ekf6mja9	628	16	and	and	CC
cord-006702-ekf6mja9	628	17	those	those	DT
cord-006702-ekf6mja9	628	18	not	not	RB
cord-006702-ekf6mja9	628	19	requiring	require	VBG
cord-006702-ekf6mja9	628	20	RBC	RBC	NNP
cord-006702-ekf6mja9	628	21	transfusions	transfusion	NNS
cord-006702-ekf6mja9	628	22	(	(	-LRB-
cord-006702-ekf6mja9	628	23	CI	CI	NNP
cord-006702-ekf6mja9	628	24	95	95	CD
cord-006702-ekf6mja9	628	25	%	%	NN
cord-006702-ekf6mja9	628	26	4.1	4.1	CD
cord-006702-ekf6mja9	628	27	-	-	SYM
cord-006702-ekf6mja9	628	28	18.5	18.5	CD
cord-006702-ekf6mja9	628	29	,	,	,
cord-006702-ekf6mja9	628	30	p<0.0001	p<0.0001	NNP
cord-006702-ekf6mja9	628	31	and	and	CC
cord-006702-ekf6mja9	628	32	CI	CI	NNP
cord-006702-ekf6mja9	628	33	95	95	CD
cord-006702-ekf6mja9	628	34	%	%	NN
cord-006702-ekf6mja9	628	35	1.6	1.6	CD
cord-006702-ekf6mja9	628	36	-	-	SYM
cord-006702-ekf6mja9	628	37	6.3	6.3	CD
cord-006702-ekf6mja9	628	38	,	,	,
cord-006702-ekf6mja9	628	39	p=	p=	NN
cord-006702-ekf6mja9	628	40	0.0009	0.0009	CD
cord-006702-ekf6mja9	628	41	respectively	respectively	RB
cord-006702-ekf6mja9	628	42	)	)	-RRB-
cord-006702-ekf6mja9	628	43	.	.	.
cord-006702-ekf6mja9	629	1	Considering	consider	VBG
cord-006702-ekf6mja9	629	2	only	only	RB
cord-006702-ekf6mja9	629	3	patients	patient	NNS
cord-006702-ekf6mja9	629	4	with	with	IN
cord-006702-ekf6mja9	629	5	≥	≥	CD
cord-006702-ekf6mja9	629	6	10	10	CD
cord-006702-ekf6mja9	629	7	days	day	NNS
cord-006702-ekf6mja9	629	8	of	of	IN
cord-006702-ekf6mja9	629	9	dialysis	dialysis	NN
cord-006702-ekf6mja9	629	10	,	,	,
cord-006702-ekf6mja9	629	11	26	26	CD
cord-006702-ekf6mja9	629	12	%	%	NN
cord-006702-ekf6mja9	629	13	of	of	IN
cord-006702-ekf6mja9	629	14	those	those	DT
cord-006702-ekf6mja9	629	15	who	who	WP
cord-006702-ekf6mja9	629	16	received	receive	VBD
cord-006702-ekf6mja9	629	17	RBC	RBC	NNP
cord-006702-ekf6mja9	629	18	transfusions	transfusion	NNS
cord-006702-ekf6mja9	629	19	were	be	VBD
cord-006702-ekf6mja9	629	20	in	in	IN
cord-006702-ekf6mja9	629	21	CKD	CKD	NNP
cord-006702-ekf6mja9	629	22	stage	stage	NN
cord-006702-ekf6mja9	629	23	2	2	CD
cord-006702-ekf6mja9	629	24	-	-	SYM
cord-006702-ekf6mja9	629	25	5	5	CD
cord-006702-ekf6mja9	629	26	vs.	vs.	CC
cord-006702-ekf6mja9	629	27	61	61	CD
cord-006702-ekf6mja9	629	28	%	%	NN
cord-006702-ekf6mja9	629	29	of	of	IN
cord-006702-ekf6mja9	629	30	those	those	DT
cord-006702-ekf6mja9	629	31	who	who	WP
cord-006702-ekf6mja9	629	32	did	do	VBD
cord-006702-ekf6mja9	629	33	not	not	RB
cord-006702-ekf6mja9	629	34	(	(	-LRB-
cord-006702-ekf6mja9	629	35	p=0.0009	p=0.0009	NNP
cord-006702-ekf6mja9	629	36	,	,	,
cord-006702-ekf6mja9	629	37	OR	or	CC
cord-006702-ekf6mja9	629	38	6.4	6.4	CD
cord-006702-ekf6mja9	629	39	CI	CI	NNP
cord-006702-ekf6mja9	629	40	95	95	CD
cord-006702-ekf6mja9	629	41	%	%	NN
cord-006702-ekf6mja9	629	42	2	2	CD
cord-006702-ekf6mja9	629	43	-	-	SYM
cord-006702-ekf6mja9	629	44	20	20	CD
cord-006702-ekf6mja9	629	45	)	)	-RRB-
cord-006702-ekf6mja9	629	46	.	.	.
cord-006702-ekf6mja9	630	1	The	the	DT
cord-006702-ekf6mja9	630	2	association	association	NN
cord-006702-ekf6mja9	630	3	between	between	IN
cord-006702-ekf6mja9	630	4	≥10	≥10	NNP
cord-006702-ekf6mja9	630	5	days	day	NNS
cord-006702-ekf6mja9	630	6	of	of	IN
cord-006702-ekf6mja9	630	7	dialysis	dialysis	NN
cord-006702-ekf6mja9	630	8	and	and	CC
cord-006702-ekf6mja9	630	9	no	no	DT
cord-006702-ekf6mja9	630	10	transfusion	transfusion	NN
cord-006702-ekf6mja9	630	11	requirement	requirement	NN
cord-006702-ekf6mja9	630	12	was	be	VBD
cord-006702-ekf6mja9	630	13	the	the	DT
cord-006702-ekf6mja9	630	14	most	most	RBS
cord-006702-ekf6mja9	630	15	important	important	JJ
cord-006702-ekf6mja9	630	16	predictor	predictor	NN
cord-006702-ekf6mja9	630	17	of	of	IN
cord-006702-ekf6mja9	630	18	long	long	JJ
cord-006702-ekf6mja9	630	19	-	-	HYPH
cord-006702-ekf6mja9	630	20	term	term	NN
cord-006702-ekf6mja9	630	21	CKD	CKD	NNP
cord-006702-ekf6mja9	630	22	.	.	.
cord-006702-ekf6mja9	631	1	No	no	DT
cord-006702-ekf6mja9	631	2	transfusional	transfusional	JJ
cord-006702-ekf6mja9	631	3	requirement	requirement	NN
cord-006702-ekf6mja9	631	4	implies	imply	VBZ
cord-006702-ekf6mja9	631	5	less	less	JJR
cord-006702-ekf6mja9	631	6	hemolysis	hemolysis	NN
cord-006702-ekf6mja9	631	7	probably	probably	RB
cord-006702-ekf6mja9	631	8	related	relate	VBD
cord-006702-ekf6mja9	631	9	to	to	IN
cord-006702-ekf6mja9	631	10	more	more	RBR
cord-006702-ekf6mja9	631	11	severe	severe	JJ
cord-006702-ekf6mja9	631	12	vascular	vascular	JJ
cord-006702-ekf6mja9	631	13	occlusion	occlusion	NN
cord-006702-ekf6mja9	631	14	leading	lead	VBG
cord-006702-ekf6mja9	631	15	to	to	IN
cord-006702-ekf6mja9	631	16	more	more	JJR
cord-006702-ekf6mja9	631	17	ischemia	ischemia	NN
cord-006702-ekf6mja9	631	18	and	and	CC
cord-006702-ekf6mja9	631	19	poor	poor	JJ
cord-006702-ekf6mja9	631	20	long	long	JJ
cord-006702-ekf6mja9	631	21	term	term	NN
cord-006702-ekf6mja9	631	22	renal	renal	JJ
cord-006702-ekf6mja9	631	23	outcome	outcome	NN
cord-006702-ekf6mja9	631	24	.	.	.
cord-006702-ekf6mja9	632	1	FP	FP	NNP
cord-006702-ekf6mja9	632	2	-	-	HYPH
cord-006702-ekf6mja9	632	3	S19	S19	NNP
cord-006702-ekf6mja9	632	4	-	-	HYPH
cord-006702-ekf6mja9	632	5	1	1	CD
cord-006702-ekf6mja9	633	1	The	the	DT
cord-006702-ekf6mja9	633	2	impacts	impact	NNS
cord-006702-ekf6mja9	633	3	of	of	IN
cord-006702-ekf6mja9	633	4	interdialytic	interdialytic	JJ
cord-006702-ekf6mja9	633	5	weight	weight	NN
cord-006702-ekf6mja9	633	6	gain	gain	NN
cord-006702-ekf6mja9	633	7	on	on	IN
cord-006702-ekf6mja9	633	8	chronic	chronic	JJ
cord-006702-ekf6mja9	633	9	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	633	10	in	in	IN
cord-006702-ekf6mja9	633	11	low	low	JJ
cord-006702-ekf6mja9	633	12	weight	weight	NN
cord-006702-ekf6mja9	633	13	children	child	NNS
cord-006702-ekf6mja9	633	14	C.	C.	NNP
cord-006702-ekf6mja9	633	15	Henriques	Henriques	NNP
cord-006702-ekf6mja9	633	16	,	,	,
cord-006702-ekf6mja9	633	17	M.F.C.	M.F.C.	NNP
cord-006702-ekf6mja9	633	18	Camargo	Camargo	NNP
cord-006702-ekf6mja9	633	19	,	,	,
cord-006702-ekf6mja9	633	20	M.F.S.	M.F.S.	NNP
cord-006702-ekf6mja9	633	21	Jardim	Jardim	NNP
cord-006702-ekf6mja9	633	22	,	,	,
cord-006702-ekf6mja9	633	23	S.	S.	NNP
cord-006702-ekf6mja9	633	24	Komi	Komi	NNP
cord-006702-ekf6mja9	633	25	,	,	,
cord-006702-ekf6mja9	633	26	S.	S.	NNP
cord-006702-ekf6mja9	633	27	Vieira	Vieira	NNP
cord-006702-ekf6mja9	633	28	,	,	,
cord-006702-ekf6mja9	633	29	P.C.K.	P.C.K.	NNP
cord-006702-ekf6mja9	633	30	Nogueira	Nogueira	NNP
cord-006702-ekf6mja9	633	31	Hospital	Hospital	NNP
cord-006702-ekf6mja9	633	32	Samaritano	Samaritano	NNP
cord-006702-ekf6mja9	633	33	,	,	,
cord-006702-ekf6mja9	633	34	sao	sao	NNP
cord-006702-ekf6mja9	633	35	paulo	paulo	NNP
cord-006702-ekf6mja9	633	36	,	,	,
cord-006702-ekf6mja9	634	1	Brazil	Brazil	NNP
cord-006702-ekf6mja9	634	2	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	634	3	:	:	:
cord-006702-ekf6mja9	635	1	To	to	TO
cord-006702-ekf6mja9	635	2	assess	assess	VB
cord-006702-ekf6mja9	635	3	the	the	DT
cord-006702-ekf6mja9	635	4	impacts	impact	NNS
cord-006702-ekf6mja9	635	5	of	of	IN
cord-006702-ekf6mja9	635	6	interdialytic	interdialytic	JJ
cord-006702-ekf6mja9	635	7	weight	weight	NN
cord-006702-ekf6mja9	635	8	gain	gain	NN
cord-006702-ekf6mja9	635	9	(	(	-LRB-
cord-006702-ekf6mja9	635	10	IDWG	IDWG	NNP
cord-006702-ekf6mja9	635	11	)	)	-RRB-
cord-006702-ekf6mja9	635	12	in	in	IN
cord-006702-ekf6mja9	635	13	low	low	JJ
cord-006702-ekf6mja9	635	14	weight	weight	NN
cord-006702-ekf6mja9	635	15	children	child	NNS
cord-006702-ekf6mja9	635	16	undergoing	undergo	VBG
cord-006702-ekf6mja9	635	17	chronic	chronic	JJ
cord-006702-ekf6mja9	635	18	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	635	19	(	(	-LRB-
cord-006702-ekf6mja9	635	20	HD	HD	NNP
cord-006702-ekf6mja9	635	21	)	)	-RRB-
cord-006702-ekf6mja9	635	22	.	.	.
cord-006702-ekf6mja9	636	1	Methods	method	NNS
cord-006702-ekf6mja9	636	2	:	:	:
cord-006702-ekf6mja9	637	1	Prospective	prospective	JJ
cord-006702-ekf6mja9	637	2	cohort	cohort	NN
cord-006702-ekf6mja9	637	3	of	of	IN
cord-006702-ekf6mja9	637	4	30	30	CD
cord-006702-ekf6mja9	637	5	patients	patient	NNS
cord-006702-ekf6mja9	637	6	(	(	-LRB-
cord-006702-ekf6mja9	637	7	8F	8f	NN
cord-006702-ekf6mja9	637	8	,	,	,
cord-006702-ekf6mja9	637	9	22	22	CD
cord-006702-ekf6mja9	637	10	M	M	NNP
cord-006702-ekf6mja9	637	11	)	)	-RRB-
cord-006702-ekf6mja9	637	12	,	,	,
cord-006702-ekf6mja9	637	13	with	with	IN
cord-006702-ekf6mja9	637	14	mean	mean	JJ
cord-006702-ekf6mja9	637	15	age	age	NN
cord-006702-ekf6mja9	637	16	of	of	IN
cord-006702-ekf6mja9	637	17	2.4	2.4	CD
cord-006702-ekf6mja9	637	18	years	year	NNS
cord-006702-ekf6mja9	637	19	(	(	-LRB-
cord-006702-ekf6mja9	637	20	20	20	CD
cord-006702-ekf6mja9	637	21	days	day	NNS
cord-006702-ekf6mja9	637	22	-6.8	-6.8	VBP
cord-006702-ekf6mja9	637	23	years	year	NNS
cord-006702-ekf6mja9	637	24	)	)	-RRB-
cord-006702-ekf6mja9	637	25	,	,	,
cord-006702-ekf6mja9	637	26	mean	mean	JJ
cord-006702-ekf6mja9	637	27	weight	weight	NN
cord-006702-ekf6mja9	637	28	of	of	IN
cord-006702-ekf6mja9	637	29	8.4Kg	8.4kg	CD
cord-006702-ekf6mja9	637	30	(	(	-LRB-
cord-006702-ekf6mja9	637	31	2.8	2.8	CD
cord-006702-ekf6mja9	637	32	-13.7	-13.7	CD
cord-006702-ekf6mja9	637	33	)	)	-RRB-
cord-006702-ekf6mja9	637	34	and	and	CC
cord-006702-ekf6mja9	637	35	median	median	JJ
cord-006702-ekf6mja9	637	36	follow	follow	VB
cord-006702-ekf6mja9	637	37	up	up	IN
cord-006702-ekf6mja9	637	38	of	of	IN
cord-006702-ekf6mja9	637	39	231	231	CD
cord-006702-ekf6mja9	637	40	days	day	NNS
cord-006702-ekf6mja9	637	41	(	(	-LRB-
cord-006702-ekf6mja9	637	42	IQR=120	IQR=120	NNP
cord-006702-ekf6mja9	637	43	-	-	HYPH
cord-006702-ekf6mja9	637	44	334	334	CD
cord-006702-ekf6mja9	637	45	)	)	-RRB-
cord-006702-ekf6mja9	637	46	.	.	.
cord-006702-ekf6mja9	638	1	The	the	DT
cord-006702-ekf6mja9	638	2	median	median	JJ
cord-006702-ekf6mja9	638	3	number	number	NN
cord-006702-ekf6mja9	638	4	of	of	IN
cord-006702-ekf6mja9	638	5	HD	hd	NN
cord-006702-ekf6mja9	638	6	sessions	session	NNS
cord-006702-ekf6mja9	638	7	/	/	SYM
cord-006702-ekf6mja9	638	8	week	week	NN
cord-006702-ekf6mja9	638	9	was	be	VBD
cord-006702-ekf6mja9	638	10	6	6	CD
cord-006702-ekf6mja9	638	11	(	(	-LRB-
cord-006702-ekf6mja9	638	12	only	only	RB
cord-006702-ekf6mja9	638	13	1	1	CD
cord-006702-ekf6mja9	638	14	child	child	NN
cord-006702-ekf6mja9	638	15	underwent	undergo	VBD
cord-006702-ekf6mja9	638	16	conventional	conventional	JJ
cord-006702-ekf6mja9	638	17	HD	hd	NN
cord-006702-ekf6mja9	638	18	with	with	IN
cord-006702-ekf6mja9	638	19	3	3	CD
cord-006702-ekf6mja9	638	20	sessions	session	NNS
cord-006702-ekf6mja9	638	21	/	/	SYM
cord-006702-ekf6mja9	638	22	week	week	NN
cord-006702-ekf6mja9	638	23	)	)	-RRB-
cord-006702-ekf6mja9	638	24	.	.	.
cord-006702-ekf6mja9	639	1	We	-PRON-	PRP
cord-006702-ekf6mja9	639	2	evaluated	evaluate	VBD
cord-006702-ekf6mja9	639	3	the	the	DT
cord-006702-ekf6mja9	639	4	median	median	NN
cord-006702-ekf6mja9	639	5	of	of	IN
cord-006702-ekf6mja9	639	6	monthly	monthly	JJ
cord-006702-ekf6mja9	639	7	IDWG	IDWG	NNP
cord-006702-ekf6mja9	639	8	,	,	,
cord-006702-ekf6mja9	639	9	defined	define	VBN
cord-006702-ekf6mja9	639	10	as	as	IN
cord-006702-ekf6mja9	639	11	the	the	DT
cord-006702-ekf6mja9	639	12	difference	difference	NN
cord-006702-ekf6mja9	639	13	between	between	IN
cord-006702-ekf6mja9	639	14	the	the	DT
cord-006702-ekf6mja9	639	15	weight	weight	NN
cord-006702-ekf6mja9	639	16	pre	pre	JJ
cord-006702-ekf6mja9	639	17	HD	hd	NN
cord-006702-ekf6mja9	639	18	sessions	session	NNS
cord-006702-ekf6mja9	639	19	and	and	CC
cord-006702-ekf6mja9	639	20	the	the	DT
cord-006702-ekf6mja9	639	21	estimated	estimate	VBN
cord-006702-ekf6mja9	639	22	dry	dry	JJ
cord-006702-ekf6mja9	639	23	weight	weight	NN
cord-006702-ekf6mja9	639	24	and	and	CC
cord-006702-ekf6mja9	639	25	then	then	RB
cord-006702-ekf6mja9	639	26	tested	test	VBD
cord-006702-ekf6mja9	639	27	its	-PRON-	PRP$
cord-006702-ekf6mja9	639	28	association	association	NN
cord-006702-ekf6mja9	639	29	with	with	IN
cord-006702-ekf6mja9	639	30	:	:	:
cord-006702-ekf6mja9	639	31	a	a	LS
cord-006702-ekf6mja9	639	32	)	)	-RRB-
cord-006702-ekf6mja9	639	33	Z	z	NN
cord-006702-ekf6mja9	639	34	-	-	HYPH
cord-006702-ekf6mja9	639	35	score	score	NN
cord-006702-ekf6mja9	639	36	of	of	IN
cord-006702-ekf6mja9	639	37	left	left	JJ
cord-006702-ekf6mja9	639	38	ventricle	ventricle	NNP
cord-006702-ekf6mja9	639	39	mass	mass	NN
cord-006702-ekf6mja9	639	40	index	index	NN
cord-006702-ekf6mja9	639	41	,	,	,
cord-006702-ekf6mja9	639	42	b)hemodynamic	b)hemodynamic	DT
cord-006702-ekf6mja9	639	43	stability	stability	NN
cord-006702-ekf6mja9	639	44	of	of	IN
cord-006702-ekf6mja9	639	45	the	the	DT
cord-006702-ekf6mja9	639	46	patient	patient	NN
cord-006702-ekf6mja9	639	47	,	,	,
cord-006702-ekf6mja9	639	48	assessed	assess	VBN
cord-006702-ekf6mja9	639	49	as	as	IN
cord-006702-ekf6mja9	639	50	the	the	DT
cord-006702-ekf6mja9	639	51	dose	dose	NN
cord-006702-ekf6mja9	639	52	of	of	IN
cord-006702-ekf6mja9	639	53	vasoactive	vasoactive	JJ
cord-006702-ekf6mja9	639	54	drugs	drug	NNS
cord-006702-ekf6mja9	639	55	needed	need	VBD
cord-006702-ekf6mja9	639	56	to	to	TO
cord-006702-ekf6mja9	639	57	treat	treat	VB
cord-006702-ekf6mja9	639	58	hypotension	hypotension	NN
cord-006702-ekf6mja9	639	59	during	during	IN
cord-006702-ekf6mja9	639	60	the	the	DT
cord-006702-ekf6mja9	639	61	sessions	session	NNS
cord-006702-ekf6mja9	639	62	and	and	CC
cord-006702-ekf6mja9	639	63	c	c	NN
cord-006702-ekf6mja9	639	64	)	)	-RRB-
cord-006702-ekf6mja9	639	65	growth	growth	NN
cord-006702-ekf6mja9	639	66	,	,	,
cord-006702-ekf6mja9	639	67	assessed	assess	VBN
cord-006702-ekf6mja9	639	68	as	as	IN
cord-006702-ekf6mja9	639	69	the	the	DT
cord-006702-ekf6mja9	639	70	delta	delta	NN
cord-006702-ekf6mja9	639	71	of	of	IN
cord-006702-ekf6mja9	639	72	repeated	repeat	VBN
cord-006702-ekf6mja9	639	73	measurements	measurement	NNS
cord-006702-ekf6mja9	639	74	of	of	IN
cord-006702-ekf6mja9	639	75	height	height	NN
cord-006702-ekf6mja9	639	76	/	/	SYM
cord-006702-ekf6mja9	639	77	age	age	NN
cord-006702-ekf6mja9	639	78	Z	z	NN
cord-006702-ekf6mja9	639	79	-	-	HYPH
cord-006702-ekf6mja9	639	80	score	score	NN
cord-006702-ekf6mja9	639	81	(	(	-LRB-
cord-006702-ekf6mja9	639	82	last	last	JJ
cord-006702-ekf6mja9	639	83	minus	minus	CC
cord-006702-ekf6mja9	639	84	first	first	JJ
cord-006702-ekf6mja9	639	85	measurement	measurement	NN
cord-006702-ekf6mja9	639	86	)	)	-RRB-
cord-006702-ekf6mja9	639	87	.	.	.
cord-006702-ekf6mja9	640	1	Results	result	NNS
cord-006702-ekf6mja9	640	2	:	:	:
cord-006702-ekf6mja9	641	1	Perfoming	perfome	VBG
cord-006702-ekf6mja9	641	2	univariate	univariate	JJ
cord-006702-ekf6mja9	641	3	linear	linear	JJ
cord-006702-ekf6mja9	641	4	regression	regression	NN
cord-006702-ekf6mja9	641	5	,	,	,
cord-006702-ekf6mja9	641	6	we	-PRON-	PRP
cord-006702-ekf6mja9	641	7	observed	observe	VBD
cord-006702-ekf6mja9	641	8	significant	significant	JJ
cord-006702-ekf6mja9	641	9	associations	association	NNS
cord-006702-ekf6mja9	641	10	between	between	IN
cord-006702-ekf6mja9	641	11	the	the	DT
cord-006702-ekf6mja9	641	12	median	median	JJ
cord-006702-ekf6mja9	641	13	IDWG	IDWG	NNP
cord-006702-ekf6mja9	641	14	and	and	CC
cord-006702-ekf6mja9	641	15	:	:	:
cord-006702-ekf6mja9	641	16	a	a	LS
cord-006702-ekf6mja9	641	17	)	)	-RRB-
cord-006702-ekf6mja9	641	18	left	left	JJ
cord-006702-ekf6mja9	641	19	ventricle	ventricle	NN
cord-006702-ekf6mja9	641	20	mass	mass	NN
cord-006702-ekf6mja9	641	21	,	,	,
cord-006702-ekf6mja9	641	22	meaning	mean	VBG
cord-006702-ekf6mja9	641	23	that	that	IN
cord-006702-ekf6mja9	641	24	each	each	DT
cord-006702-ekf6mja9	641	25	1	1	CD
cord-006702-ekf6mja9	641	26	%	%	NN
cord-006702-ekf6mja9	641	27	rise	rise	NN
cord-006702-ekf6mja9	641	28	in	in	IN
cord-006702-ekf6mja9	641	29	the	the	DT
cord-006702-ekf6mja9	641	30	IDWG	IDWG	NNP
cord-006702-ekf6mja9	641	31	is	be	VBZ
cord-006702-ekf6mja9	641	32	associated	associate	VBN
cord-006702-ekf6mja9	641	33	with	with	IN
cord-006702-ekf6mja9	641	34	an	an	DT
cord-006702-ekf6mja9	641	35	elevation	elevation	NN
cord-006702-ekf6mja9	641	36	0.30	0.30	CD
cord-006702-ekf6mja9	641	37	SDS	SDS	NNP
cord-006702-ekf6mja9	641	38	in	in	IN
cord-006702-ekf6mja9	641	39	the	the	DT
cord-006702-ekf6mja9	641	40	left	left	JJ
cord-006702-ekf6mja9	641	41	ventricle	ventricle	NN
cord-006702-ekf6mja9	641	42	mass	mass	NN
cord-006702-ekf6mja9	641	43	index	index	NN
cord-006702-ekf6mja9	641	44	(	(	-LRB-
cord-006702-ekf6mja9	641	45	p=0.048	p=0.048	NNP
cord-006702-ekf6mja9	641	46	)	)	-RRB-
cord-006702-ekf6mja9	641	47	and	and	CC
cord-006702-ekf6mja9	641	48	b	b	LS
cord-006702-ekf6mja9	641	49	)	)	-RRB-
cord-006702-ekf6mja9	641	50	dopamine	dopamine	NN
cord-006702-ekf6mja9	641	51	median	median	NN
cord-006702-ekf6mja9	641	52	dose	dose	NN
cord-006702-ekf6mja9	641	53	during	during	IN
cord-006702-ekf6mja9	641	54	sessions	session	NNS
cord-006702-ekf6mja9	641	55	,	,	,
cord-006702-ekf6mja9	641	56	showing	show	VBG
cord-006702-ekf6mja9	641	57	that	that	IN
cord-006702-ekf6mja9	641	58	each	each	DT
cord-006702-ekf6mja9	641	59	1	1	CD
cord-006702-ekf6mja9	641	60	%	%	NN
cord-006702-ekf6mja9	641	61	increase	increase	NN
cord-006702-ekf6mja9	641	62	in	in	IN
cord-006702-ekf6mja9	641	63	IDWG	IDWG	NNP
cord-006702-ekf6mja9	641	64	is	be	VBZ
cord-006702-ekf6mja9	641	65	related	relate	VBN
cord-006702-ekf6mja9	641	66	to	to	IN
cord-006702-ekf6mja9	641	67	a	a	DT
cord-006702-ekf6mja9	641	68	dopamine	dopamine	NN
cord-006702-ekf6mja9	641	69	dose	dose	NN
cord-006702-ekf6mja9	641	70	increase	increase	NN
cord-006702-ekf6mja9	641	71	of	of	IN
cord-006702-ekf6mja9	641	72	0.87	0.87	CD
cord-006702-ekf6mja9	641	73	mcg	mcg	NN
cord-006702-ekf6mja9	641	74	/	/	SYM
cord-006702-ekf6mja9	641	75	kg	kg	NN
cord-006702-ekf6mja9	641	76	/	/	SYM
cord-006702-ekf6mja9	641	77	minute	minute	NN
cord-006702-ekf6mja9	641	78	(	(	-LRB-
cord-006702-ekf6mja9	641	79	p=0.020	p=0.020	NNP
cord-006702-ekf6mja9	641	80	)	)	-RRB-
cord-006702-ekf6mja9	641	81	.	.	.
cord-006702-ekf6mja9	642	1	With	with	IN
cord-006702-ekf6mja9	642	2	regard	regard	NN
cord-006702-ekf6mja9	642	3	to	to	IN
cord-006702-ekf6mja9	642	4	growth	growth	NN
cord-006702-ekf6mja9	642	5	,	,	,
cord-006702-ekf6mja9	642	6	patients	patient	NNS
cord-006702-ekf6mja9	642	7	with	with	IN
cord-006702-ekf6mja9	642	8	IDWG	IDWG	NNP
cord-006702-ekf6mja9	642	9	below	below	IN
cord-006702-ekf6mja9	642	10	the	the	DT
cord-006702-ekf6mja9	642	11	median	median	NN
cord-006702-ekf6mja9	642	12	of	of	IN
cord-006702-ekf6mja9	642	13	the	the	DT
cord-006702-ekf6mja9	642	14	sample	sample	NN
cord-006702-ekf6mja9	642	15	(	(	-LRB-
cord-006702-ekf6mja9	642	16	3.9	3.9	CD
cord-006702-ekf6mja9	642	17	%	%	NN
cord-006702-ekf6mja9	642	18	)	)	-RRB-
cord-006702-ekf6mja9	642	19	showed	show	VBD
cord-006702-ekf6mja9	642	20	an	an	DT
cord-006702-ekf6mja9	642	21	increase	increase	NN
cord-006702-ekf6mja9	642	22	of	of	IN
cord-006702-ekf6mja9	642	23	0.5	0.5	CD
cord-006702-ekf6mja9	642	24	SDS	SDS	NNP
cord-006702-ekf6mja9	642	25	in	in	IN
cord-006702-ekf6mja9	642	26	height	height	NN
cord-006702-ekf6mja9	642	27	/	/	SYM
cord-006702-ekf6mja9	642	28	age	age	NN
cord-006702-ekf6mja9	642	29	during	during	IN
cord-006702-ekf6mja9	642	30	follow	follow	NN
cord-006702-ekf6mja9	642	31	-	-	HYPH
cord-006702-ekf6mja9	642	32	up	up	NN
cord-006702-ekf6mja9	642	33	,	,	,
cord-006702-ekf6mja9	642	34	whereas	whereas	IN
cord-006702-ekf6mja9	642	35	patients	patient	NNS
cord-006702-ekf6mja9	642	36	with	with	IN
cord-006702-ekf6mja9	642	37	median	median	JJ
cord-006702-ekf6mja9	642	38	IDWG	IDWG	NNP
cord-006702-ekf6mja9	642	39	greater	great	JJR
cord-006702-ekf6mja9	642	40	than	than	IN
cord-006702-ekf6mja9	642	41	3.9	3.9	CD
cord-006702-ekf6mja9	642	42	had	have	VBD
cord-006702-ekf6mja9	642	43	a	a	DT
cord-006702-ekf6mja9	642	44	significantly	significantly	RB
cord-006702-ekf6mja9	642	45	smaller	small	JJR
cord-006702-ekf6mja9	642	46	0.1	0.1	CD
cord-006702-ekf6mja9	642	47	SDS	sds	NN
cord-006702-ekf6mja9	642	48	increase	increase	NN
cord-006702-ekf6mja9	642	49	(	(	-LRB-
cord-006702-ekf6mja9	642	50	p=0.04	p=0.04	NN
cord-006702-ekf6mja9	642	51	)	)	-RRB-
cord-006702-ekf6mja9	642	52	.	.	.
cord-006702-ekf6mja9	643	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	643	2	:	:	:
cord-006702-ekf6mja9	644	1	In	in	IN
cord-006702-ekf6mja9	644	2	our	-PRON-	PRP$
cord-006702-ekf6mja9	644	3	series	series	NN
cord-006702-ekf6mja9	644	4	,	,	,
cord-006702-ekf6mja9	644	5	IDWG	IDWG	NNP
cord-006702-ekf6mja9	644	6	was	be	VBD
cord-006702-ekf6mja9	644	7	associated	associate	VBN
cord-006702-ekf6mja9	644	8	with	with	IN
cord-006702-ekf6mja9	644	9	negative	negative	JJ
cord-006702-ekf6mja9	644	10	impacts	impact	NNS
cord-006702-ekf6mja9	644	11	such	such	JJ
cord-006702-ekf6mja9	644	12	as	as	IN
cord-006702-ekf6mja9	644	13	augmented	augment	VBN
cord-006702-ekf6mja9	644	14	left	left	JJ
cord-006702-ekf6mja9	644	15	ventricle	ventricle	NN
cord-006702-ekf6mja9	644	16	mass	mass	NN
cord-006702-ekf6mja9	644	17	,	,	,
cord-006702-ekf6mja9	644	18	increased	increase	VBN
cord-006702-ekf6mja9	644	19	need	need	NN
cord-006702-ekf6mja9	644	20	for	for	IN
cord-006702-ekf6mja9	644	21	vasoactive	vasoactive	JJ
cord-006702-ekf6mja9	644	22	drugs	drug	NNS
cord-006702-ekf6mja9	644	23	during	during	IN
cord-006702-ekf6mja9	644	24	HD	hd	NN
cord-006702-ekf6mja9	644	25	and	and	CC
cord-006702-ekf6mja9	644	26	inferior	inferior	JJ
cord-006702-ekf6mja9	644	27	growth	growth	NN
cord-006702-ekf6mja9	644	28	.	.	.
cord-006702-ekf6mja9	645	1	These	these	DT
cord-006702-ekf6mja9	645	2	facts	fact	NNS
cord-006702-ekf6mja9	645	3	reinforce	reinforce	VBP
cord-006702-ekf6mja9	645	4	the	the	DT
cord-006702-ekf6mja9	645	5	need	need	NN
cord-006702-ekf6mja9	645	6	for	for	IN
cord-006702-ekf6mja9	645	7	a	a	DT
cord-006702-ekf6mja9	645	8	strict	strict	JJ
cord-006702-ekf6mja9	645	9	control	control	NN
cord-006702-ekf6mja9	645	10	of	of	IN
cord-006702-ekf6mja9	645	11	IDWG	IDWG	NNP
cord-006702-ekf6mja9	645	12	in	in	IN
cord-006702-ekf6mja9	645	13	dialysis	dialysis	NN
cord-006702-ekf6mja9	645	14	of	of	IN
cord-006702-ekf6mja9	645	15	small	small	JJ
cord-006702-ekf6mja9	645	16	children	child	NNS
cord-006702-ekf6mja9	645	17	.	.	.
cord-006702-ekf6mja9	646	1	FP	FP	NNP
cord-006702-ekf6mja9	646	2	-	-	HYPH
cord-006702-ekf6mja9	646	3	S19	S19	NNP
cord-006702-ekf6mja9	646	4	-	-	HYPH
cord-006702-ekf6mja9	646	5	2	2	CD
cord-006702-ekf6mja9	646	6	Predominance	predominance	NN
cord-006702-ekf6mja9	646	7	of	of	IN
cord-006702-ekf6mja9	646	8	central	central	JJ
cord-006702-ekf6mja9	646	9	venous	venous	JJ
cord-006702-ekf6mja9	646	10	lines	line	NNS
cord-006702-ekf6mja9	646	11	(	(	-LRB-
cord-006702-ekf6mja9	646	12	CVL	CVL	NNP
cord-006702-ekf6mja9	646	13	)	)	-RRB-
cord-006702-ekf6mja9	646	14	in	in	IN
cord-006702-ekf6mja9	646	15	pediatric	pediatric	JJ
cord-006702-ekf6mja9	646	16	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	646	17	(	(	-LRB-
cord-006702-ekf6mja9	646	18	HD	HD	NNP
cord-006702-ekf6mja9	646	19	)	)	-RRB-
cord-006702-ekf6mja9	646	20	despite	despite	IN
cord-006702-ekf6mja9	646	21	much	much	JJ
cord-006702-ekf6mja9	646	22	higher	high	JJR
cord-006702-ekf6mja9	646	23	complication	complication	NN
cord-006702-ekf6mja9	646	24	rates	rate	NNS
cord-006702-ekf6mja9	646	25	-Report	-Report	.
cord-006702-ekf6mja9	646	26	from	from	IN
cord-006702-ekf6mja9	646	27	the	the	DT
cord-006702-ekf6mja9	646	28	International	International	NNP
cord-006702-ekf6mja9	646	29	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	646	30	Hemodialysis	Hemodialysis	NNP
cord-006702-ekf6mja9	646	31	Network	Network	NNP
cord-006702-ekf6mja9	646	32	(	(	-LRB-
cord-006702-ekf6mja9	646	33	IPHN	IPHN	NNP
cord-006702-ekf6mja9	646	34	)	)	-RRB-
cord-006702-ekf6mja9	646	35	D.	D.	NNP
cord-006702-ekf6mja9	646	36	Borzych	Borzych	NNP
cord-006702-ekf6mja9	646	37	-	-	HYPH
cord-006702-ekf6mja9	646	38	Duzalka	Duzalka	NNP
cord-006702-ekf6mja9	646	39	(	(	-LRB-
cord-006702-ekf6mja9	646	40	1	1	CD
cord-006702-ekf6mja9	646	41	)	)	-RRB-
cord-006702-ekf6mja9	646	42	,	,	,
cord-006702-ekf6mja9	646	43	R.	R.	NNP
cord-006702-ekf6mja9	646	44	Shroff	Shroff	NNP
cord-006702-ekf6mja9	646	45	(	(	-LRB-
cord-006702-ekf6mja9	646	46	2	2	CD
cord-006702-ekf6mja9	646	47	)	)	-RRB-
cord-006702-ekf6mja9	646	48	,	,	.
cord-006702-ekf6mja9	647	1	Y.N.	Y.N.	NNP
cord-006702-ekf6mja9	647	2	Lim	Lim	NNP
cord-006702-ekf6mja9	647	3	(	(	-LRB-
cord-006702-ekf6mja9	647	4	3	3	CD
cord-006702-ekf6mja9	647	5	)	)	-RRB-
cord-006702-ekf6mja9	647	6	,	,	,
cord-006702-ekf6mja9	647	7	S.	S.	NNP
cord-006702-ekf6mja9	647	8	Testa	Testa	NNP
cord-006702-ekf6mja9	647	9	(	(	-LRB-
cord-006702-ekf6mja9	647	10	4	4	CD
cord-006702-ekf6mja9	647	11	)	)	-RRB-
cord-006702-ekf6mja9	647	12	,	,	,
cord-006702-ekf6mja9	647	13	H.	H.	NNP
cord-006702-ekf6mja9	647	14	Xu	Xu	NNP
cord-006702-ekf6mja9	647	15	(	(	-LRB-
cord-006702-ekf6mja9	647	16	5	5	CD
cord-006702-ekf6mja9	647	17	)	)	-RRB-
cord-006702-ekf6mja9	647	18	,	,	,
cord-006702-ekf6mja9	647	19	B.	B.	NNP
cord-006702-ekf6mja9	647	20	Warady	Warady	NNP
cord-006702-ekf6mja9	647	21	(	(	-LRB-
cord-006702-ekf6mja9	647	22	6	6	CD
cord-006702-ekf6mja9	647	23	)	)	-RRB-
cord-006702-ekf6mja9	647	24	,	,	,
cord-006702-ekf6mja9	647	25	F.	F.	NNP
cord-006702-ekf6mja9	647	26	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	647	27	(	(	-LRB-
cord-006702-ekf6mja9	647	28	7	7	CD
cord-006702-ekf6mja9	647	29	)	)	-RRB-
cord-006702-ekf6mja9	647	30	,	,	.
cord-006702-ekf6mja9	648	1	C.P.	C.P.	NNP
cord-006702-ekf6mja9	648	2	Schmitt	Schmitt	NNP
cord-006702-ekf6mja9	648	3	(	(	-LRB-
cord-006702-ekf6mja9	648	4	8	8	CD
cord-006702-ekf6mja9	648	5	(	(	-LRB-
cord-006702-ekf6mja9	648	6	1/57	1/57	CD
cord-006702-ekf6mja9	648	7	mo	mo	NN
cord-006702-ekf6mja9	648	8	.	.	NNP
cord-006702-ekf6mja9	648	9	)	)	-RRB-
cord-006702-ekf6mja9	648	10	,	,	,
cord-006702-ekf6mja9	648	11	mainly	mainly	RB
cord-006702-ekf6mja9	648	12	including	include	VBG
cord-006702-ekf6mja9	648	13	thrombosis	thrombosis	NN
cord-006702-ekf6mja9	648	14	(	(	-LRB-
cord-006702-ekf6mja9	648	15	50	50	CD
cord-006702-ekf6mja9	648	16	%	%	NN
cord-006702-ekf6mja9	648	17	)	)	-RRB-
cord-006702-ekf6mja9	648	18	,	,	,
cord-006702-ekf6mja9	648	19	puncture	puncture	NN
cord-006702-ekf6mja9	648	20	failure	failure	NN
cord-006702-ekf6mja9	648	21	(	(	-LRB-
cord-006702-ekf6mja9	648	22	15	15	CD
cord-006702-ekf6mja9	648	23	%	%	NN
cord-006702-ekf6mja9	648	24	)	)	-RRB-
cord-006702-ekf6mja9	648	25	and	and	CC
cord-006702-ekf6mja9	648	26	insufficient	insufficient	JJ
cord-006702-ekf6mja9	648	27	flow	flow	NN
cord-006702-ekf6mja9	648	28	(	(	-LRB-
cord-006702-ekf6mja9	648	29	7	7	CD
cord-006702-ekf6mja9	648	30	%	%	NN
cord-006702-ekf6mja9	648	31	)	)	-RRB-
cord-006702-ekf6mja9	648	32	.	.	.
cord-006702-ekf6mja9	649	1	In	in	IN
cord-006702-ekf6mja9	649	2	11	11	CD
cord-006702-ekf6mja9	649	3	cases	case	NNS
cord-006702-ekf6mja9	649	4	an	an	DT
cord-006702-ekf6mja9	649	5	access	access	NN
cord-006702-ekf6mja9	649	6	revision	revision	NN
cord-006702-ekf6mja9	649	7	was	be	VBD
cord-006702-ekf6mja9	649	8	performed	perform	VBN
cord-006702-ekf6mja9	649	9	,	,	,
cord-006702-ekf6mja9	649	10	while	while	IN
cord-006702-ekf6mja9	649	11	in	in	IN
cord-006702-ekf6mja9	649	12	21	21	CD
cord-006702-ekf6mja9	649	13	a	a	DT
cord-006702-ekf6mja9	649	14	new	new	JJ
cord-006702-ekf6mja9	649	15	access	access	NN
cord-006702-ekf6mja9	649	16	was	be	VBD
cord-006702-ekf6mja9	649	17	created	create	VBN
cord-006702-ekf6mja9	649	18	.	.	.
cord-006702-ekf6mja9	650	1	One	one	CD
cord-006702-ekf6mja9	650	2	,	,	,
cord-006702-ekf6mja9	650	3	two	two	CD
cord-006702-ekf6mja9	650	4	and	and	CC
cord-006702-ekf6mja9	650	5	three	three	CD
cord-006702-ekf6mja9	650	6	year	year	NN
cord-006702-ekf6mja9	650	7	patency	patency	NN
cord-006702-ekf6mja9	650	8	rates	rate	NNS
cord-006702-ekf6mja9	650	9	were	be	VBD
cord-006702-ekf6mja9	650	10	significantly	significantly	RB
cord-006702-ekf6mja9	650	11	higher	high	JJR
cord-006702-ekf6mja9	650	12	for	for	IN
cord-006702-ekf6mja9	650	13	AVF	AVF	NNP
cord-006702-ekf6mja9	650	14	/	/	SYM
cord-006702-ekf6mja9	650	15	AVG	avg	NN
cord-006702-ekf6mja9	650	16	than	than	IN
cord-006702-ekf6mja9	650	17	CVL	CVL	NNP
cord-006702-ekf6mja9	650	18	(	(	-LRB-
cord-006702-ekf6mja9	650	19	0.92	0.92	CD
cord-006702-ekf6mja9	650	20	,	,	,
cord-006702-ekf6mja9	650	21	0.90	0.90	CD
cord-006702-ekf6mja9	650	22	,	,	,
cord-006702-ekf6mja9	650	23	0.81	0.81	CD
cord-006702-ekf6mja9	650	24	and	and	CC
cord-006702-ekf6mja9	650	25	0.84	0.84	CD
cord-006702-ekf6mja9	650	26	,	,	,
cord-006702-ekf6mja9	650	27	0.60	0.60	CD
cord-006702-ekf6mja9	650	28	,	,	,
cord-006702-ekf6mja9	650	29	0.30	0.30	CD
cord-006702-ekf6mja9	650	30	,	,	,
cord-006702-ekf6mja9	650	31	respectively	respectively	RB
cord-006702-ekf6mja9	650	32	)	)	-RRB-
cord-006702-ekf6mja9	650	33	.	.	.
cord-006702-ekf6mja9	651	1	The	the	DT
cord-006702-ekf6mja9	651	2	use	use	NN
cord-006702-ekf6mja9	651	3	of	of	IN
cord-006702-ekf6mja9	651	4	CVL	CVL	NNP
cord-006702-ekf6mja9	651	5	increased	increase	VBD
cord-006702-ekf6mja9	651	6	the	the	DT
cord-006702-ekf6mja9	651	7	risk	risk	NN
cord-006702-ekf6mja9	651	8	of	of	IN
cord-006702-ekf6mja9	651	9	access	access	NN
cord-006702-ekf6mja9	651	10	revision	revision	NN
cord-006702-ekf6mja9	651	11	4.8-fold	4.8-fold	CD
cord-006702-ekf6mja9	651	12	(	(	-LRB-
cord-006702-ekf6mja9	651	13	p<0.0001	p<0.0001	NNP
cord-006702-ekf6mja9	651	14	)	)	-RRB-
cord-006702-ekf6mja9	651	15	,	,	,
cord-006702-ekf6mja9	651	16	as	as	IN
cord-006702-ekf6mja9	651	17	compared	compare	VBN
cord-006702-ekf6mja9	651	18	to	to	IN
cord-006702-ekf6mja9	651	19	AVF	AVF	NNP
cord-006702-ekf6mja9	651	20	/	/	SYM
cord-006702-ekf6mja9	651	21	AVG	AVG	NNP
cord-006702-ekf6mja9	651	22	Conclusions	Conclusions	NNPS
cord-006702-ekf6mja9	651	23	:	:	:
cord-006702-ekf6mja9	651	24	This	this	DT
cord-006702-ekf6mja9	651	25	is	be	VBZ
cord-006702-ekf6mja9	651	26	the	the	DT
cord-006702-ekf6mja9	651	27	largest	large	JJS
cord-006702-ekf6mja9	651	28	prospective	prospective	JJ
cord-006702-ekf6mja9	651	29	pediatric	pediatric	JJ
cord-006702-ekf6mja9	651	30	report	report	NN
cord-006702-ekf6mja9	651	31	on	on	IN
cord-006702-ekf6mja9	651	32	vascular	vascular	JJ
cord-006702-ekf6mja9	651	33	access	access	NN
cord-006702-ekf6mja9	651	34	in	in	IN
cord-006702-ekf6mja9	651	35	HD	hd	NN
cord-006702-ekf6mja9	651	36	.	.	.
cord-006702-ekf6mja9	652	1	CVL	CVL	NNP
cord-006702-ekf6mja9	652	2	remain	remain	VBP
cord-006702-ekf6mja9	652	3	by	by	IN
cord-006702-ekf6mja9	652	4	far	far	RB
cord-006702-ekf6mja9	652	5	the	the	DT
cord-006702-ekf6mja9	652	6	first	first	JJ
cord-006702-ekf6mja9	652	7	choice	choice	NN
cord-006702-ekf6mja9	652	8	,	,	,
cord-006702-ekf6mja9	652	9	despite	despite	IN
cord-006702-ekf6mja9	652	10	much	much	JJ
cord-006702-ekf6mja9	652	11	higher	high	JJR
cord-006702-ekf6mja9	652	12	complication	complication	NN
cord-006702-ekf6mja9	652	13	rates	rate	NNS
cord-006702-ekf6mja9	652	14	.	.	.
cord-006702-ekf6mja9	653	1	Infectious	infectious	JJ
cord-006702-ekf6mja9	653	2	complications	complication	NNS
cord-006702-ekf6mja9	653	3	exclusively	exclusively	RB
cord-006702-ekf6mja9	653	4	occurred	occur	VBD
cord-006702-ekf6mja9	653	5	in	in	IN
cord-006702-ekf6mja9	653	6	pts	pts	NN
cord-006702-ekf6mja9	653	7	with	with	IN
cord-006702-ekf6mja9	653	8	CVL	CVL	NNP
cord-006702-ekf6mja9	653	9	,	,	,
cord-006702-ekf6mja9	653	10	and	and	CC
cord-006702-ekf6mja9	653	11	access	access	NN
cord-006702-ekf6mja9	653	12	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	653	13	risk	risk	NN
cord-006702-ekf6mja9	653	14	markedly	markedly	RB
cord-006702-ekf6mja9	653	15	increased	increase	VBD
cord-006702-ekf6mja9	653	16	with	with	IN
cord-006702-ekf6mja9	653	17	CVL	CVL	NNP
cord-006702-ekf6mja9	653	18	use	use	NN
cord-006702-ekf6mja9	653	19	FP	FP	NNP
cord-006702-ekf6mja9	653	20	-	-	HYPH
cord-006702-ekf6mja9	653	21	S19	S19	NNP
cord-006702-ekf6mja9	653	22	-	-	HYPH
cord-006702-ekf6mja9	653	23	3	3	CD
cord-006702-ekf6mja9	653	24	Acute	acute	JJ
cord-006702-ekf6mja9	653	25	pancreatitis	pancreatitis	NN
cord-006702-ekf6mja9	653	26	in	in	IN
cord-006702-ekf6mja9	653	27	children	child	NNS
cord-006702-ekf6mja9	653	28	on	on	IN
cord-006702-ekf6mja9	653	29	chronic	chronic	JJ
cord-006702-ekf6mja9	653	30	dialysis	dialysis	NN
cord-006702-ekf6mja9	653	31	:	:	:
cord-006702-ekf6mja9	653	32	incidence	incidence	NN
cord-006702-ekf6mja9	653	33	and	and	CC
cord-006702-ekf6mja9	653	34	clinical	clinical	JJ
cord-006702-ekf6mja9	653	35	characteristic	characteristic	NN
cord-006702-ekf6mja9	653	36	in	in	IN
cord-006702-ekf6mja9	653	37	a	a	DT
cord-006702-ekf6mja9	653	38	nationwide	nationwide	JJ
cord-006702-ekf6mja9	653	39	registry	registry	NN
cord-006702-ekf6mja9	653	40	.	.	.
cord-006702-ekf6mja9	654	1	E.	E.	NNP
cord-006702-ekf6mja9	654	2	Vidal	Vidal	NNP
cord-006702-ekf6mja9	654	3	(	(	-LRB-
cord-006702-ekf6mja9	654	4	1	1	CD
cord-006702-ekf6mja9	654	5	)	)	-RRB-
cord-006702-ekf6mja9	654	6	,	,	,
cord-006702-ekf6mja9	654	7	I.	I.	NNP
cord-006702-ekf6mja9	654	8	Alberici	Alberici	NNP
cord-006702-ekf6mja9	654	9	(	(	-LRB-
cord-006702-ekf6mja9	654	10	1	1	CD
cord-006702-ekf6mja9	654	11	)	)	-RRB-
cord-006702-ekf6mja9	654	12	,	,	,
cord-006702-ekf6mja9	654	13	M.	M.	NNP
cord-006702-ekf6mja9	654	14	Martino	Martino	NNP
cord-006702-ekf6mja9	654	15	(	(	-LRB-
cord-006702-ekf6mja9	654	16	2	2	CD
cord-006702-ekf6mja9	654	17	)	)	-RRB-
cord-006702-ekf6mja9	654	18	,	,	,
cord-006702-ekf6mja9	654	19	S.	S.	NNP
cord-006702-ekf6mja9	654	20	Picca	Picca	NNP
cord-006702-ekf6mja9	654	21	(	(	-LRB-
cord-006702-ekf6mja9	654	22	3	3	CD
cord-006702-ekf6mja9	654	23	)	)	-RRB-
cord-006702-ekf6mja9	654	24	,	,	,
cord-006702-ekf6mja9	654	25	C.	C.	NNP
cord-006702-ekf6mja9	654	26	Pecoraro	Pecoraro	NNP
cord-006702-ekf6mja9	654	27	(	(	-LRB-
cord-006702-ekf6mja9	654	28	4	4	CD
cord-006702-ekf6mja9	654	29	)	)	-RRB-
cord-006702-ekf6mja9	654	30	,	,	,
cord-006702-ekf6mja9	654	31	C.	C.	NNP
cord-006702-ekf6mja9	654	32	Corrado	Corrado	NNP
cord-006702-ekf6mja9	654	33	(	(	-LRB-
cord-006702-ekf6mja9	654	34	5	5	CD
cord-006702-ekf6mja9	654	35	)	)	-RRB-
cord-006702-ekf6mja9	654	36	,	,	,
cord-006702-ekf6mja9	654	37	I.M.	I.M.	NNP
cord-006702-ekf6mja9	654	38	Ratsch	Ratsch	NNP
cord-006702-ekf6mja9	654	39	(	(	-LRB-
cord-006702-ekf6mja9	654	40	6	6	CD
cord-006702-ekf6mja9	654	41	)	)	-RRB-
cord-006702-ekf6mja9	654	42	,	,	,
cord-006702-ekf6mja9	654	43	E.	E.	NNP
cord-006702-ekf6mja9	654	44	Verrina	Verrina	NNP
cord-006702-ekf6mja9	654	45	(	(	-LRB-
cord-006702-ekf6mja9	654	46	7	7	CD
cord-006702-ekf6mja9	654	47	Objectives	objective	NNS
cord-006702-ekf6mja9	654	48	:	:	:
cord-006702-ekf6mja9	655	1	The	the	DT
cord-006702-ekf6mja9	655	2	risk	risk	NN
cord-006702-ekf6mja9	655	3	of	of	IN
cord-006702-ekf6mja9	655	4	acute	acute	JJ
cord-006702-ekf6mja9	655	5	pancreatitis	pancreatitis	NN
cord-006702-ekf6mja9	655	6	(	(	-LRB-
cord-006702-ekf6mja9	655	7	AP	AP	NNP
cord-006702-ekf6mja9	655	8	)	)	-RRB-
cord-006702-ekf6mja9	655	9	is	be	VBZ
cord-006702-ekf6mja9	655	10	increased	increase	VBN
cord-006702-ekf6mja9	655	11	in	in	IN
cord-006702-ekf6mja9	655	12	patients	patient	NNS
cord-006702-ekf6mja9	655	13	(	(	-LRB-
cord-006702-ekf6mja9	655	14	pts	pt	NNS
cord-006702-ekf6mja9	655	15	)	)	-RRB-
cord-006702-ekf6mja9	655	16	with	with	IN
cord-006702-ekf6mja9	655	17	end	end	NN
cord-006702-ekf6mja9	655	18	-	-	HYPH
cord-006702-ekf6mja9	655	19	stage	stage	NN
cord-006702-ekf6mja9	655	20	renal	renal	JJ
cord-006702-ekf6mja9	655	21	disease	disease	NN
cord-006702-ekf6mja9	655	22	(	(	-LRB-
cord-006702-ekf6mja9	655	23	ESRD	ESRD	NNP
cord-006702-ekf6mja9	655	24	)	)	-RRB-
cord-006702-ekf6mja9	655	25	on	on	IN
cord-006702-ekf6mja9	655	26	dialysis	dialysis	NN
cord-006702-ekf6mja9	655	27	.	.	.
cord-006702-ekf6mja9	656	1	To	to	IN
cord-006702-ekf6mja9	656	2	our	-PRON-	PRP$
cord-006702-ekf6mja9	656	3	knowledge	knowledge	NN
cord-006702-ekf6mja9	656	4	,	,	,
cord-006702-ekf6mja9	656	5	this	this	DT
cord-006702-ekf6mja9	656	6	hypothesis	hypothesis	NN
cord-006702-ekf6mja9	656	7	has	have	VBZ
cord-006702-ekf6mja9	656	8	never	never	RB
cord-006702-ekf6mja9	656	9	been	be	VBN
cord-006702-ekf6mja9	656	10	explored	explore	VBN
cord-006702-ekf6mja9	656	11	in	in	IN
cord-006702-ekf6mja9	656	12	children	child	NNS
cord-006702-ekf6mja9	656	13	.	.	.
cord-006702-ekf6mja9	657	1	In	in	IN
cord-006702-ekf6mja9	657	2	this	this	DT
cord-006702-ekf6mja9	657	3	study	study	NN
cord-006702-ekf6mja9	657	4	we	-PRON-	PRP
cord-006702-ekf6mja9	657	5	evaluated	evaluate	VBD
cord-006702-ekf6mja9	657	6	incidence	incidence	NN
cord-006702-ekf6mja9	657	7	,	,	,
cord-006702-ekf6mja9	657	8	clinical	clinical	JJ
cord-006702-ekf6mja9	657	9	characteristics	characteristic	NNS
cord-006702-ekf6mja9	657	10	and	and	CC
cord-006702-ekf6mja9	657	11	outcome	outcome	NN
cord-006702-ekf6mja9	657	12	of	of	IN
cord-006702-ekf6mja9	657	13	AP	AP	NNP
cord-006702-ekf6mja9	657	14	in	in	IN
cord-006702-ekf6mja9	657	15	a	a	DT
cord-006702-ekf6mja9	657	16	large	large	JJ
cord-006702-ekf6mja9	657	17	pediatric	pediatric	JJ
cord-006702-ekf6mja9	657	18	chronic	chronic	JJ
cord-006702-ekf6mja9	657	19	dialysis	dialysis	NN
cord-006702-ekf6mja9	657	20	population	population	NN
cord-006702-ekf6mja9	657	21	.	.	.
cord-006702-ekf6mja9	658	1	Methods	method	NNS
cord-006702-ekf6mja9	658	2	:	:	:
cord-006702-ekf6mja9	658	3	AP	AP	NNP
cord-006702-ekf6mja9	658	4	cases	case	NNS
cord-006702-ekf6mja9	658	5	were	be	VBD
cord-006702-ekf6mja9	658	6	identified	identify	VBN
cord-006702-ekf6mja9	658	7	by	by	IN
cord-006702-ekf6mja9	658	8	reviewing	review	VBG
cord-006702-ekf6mja9	658	9	files	file	NNS
cord-006702-ekf6mja9	658	10	of	of	IN
cord-006702-ekf6mja9	658	11	all	all	DT
cord-006702-ekf6mja9	658	12	pts	pts	NN
cord-006702-ekf6mja9	658	13	starting	start	VBG
cord-006702-ekf6mja9	658	14	dialysis	dialysis	NN
cord-006702-ekf6mja9	658	15	at	at	IN
cord-006702-ekf6mja9	658	16	<	<	NNP
cord-006702-ekf6mja9	658	17	18	18	CD
cord-006702-ekf6mja9	658	18	yrs	yr	NNS
cord-006702-ekf6mja9	658	19	of	of	IN
cord-006702-ekf6mja9	658	20	age	age	NN
cord-006702-ekf6mja9	658	21	recorded	record	VBN
cord-006702-ekf6mja9	658	22	from	from	IN
cord-006702-ekf6mja9	658	23	Jan	Jan	NNP
cord-006702-ekf6mja9	658	24	2000	2000	CD
cord-006702-ekf6mja9	658	25	to	to	IN
cord-006702-ekf6mja9	658	26	Dec	Dec	NNP
cord-006702-ekf6mja9	658	27	2014	2014	CD
cord-006702-ekf6mja9	658	28	in	in	IN
cord-006702-ekf6mja9	658	29	a	a	DT
cord-006702-ekf6mja9	658	30	nationwide	nationwide	JJ
cord-006702-ekf6mja9	658	31	registry	registry	NN
cord-006702-ekf6mja9	658	32	.	.	.
cord-006702-ekf6mja9	659	1	Results	result	NNS
cord-006702-ekf6mja9	659	2	:	:	:
cord-006702-ekf6mja9	660	1	133	133	CD
cord-006702-ekf6mja9	660	2	and	and	CC
cord-006702-ekf6mja9	660	3	237	237	CD
cord-006702-ekf6mja9	660	4	eligible	eligible	JJ
cord-006702-ekf6mja9	660	5	pts	pt	NNS
cord-006702-ekf6mja9	660	6	were	be	VBD
cord-006702-ekf6mja9	660	7	identified	identify	VBN
cord-006702-ekf6mja9	660	8	in	in	IN
cord-006702-ekf6mja9	660	9	the	the	DT
cord-006702-ekf6mja9	660	10	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	660	11	dialysis	dialysis	NN
cord-006702-ekf6mja9	660	12	(	(	-LRB-
cord-006702-ekf6mja9	660	13	PD	PD	NNP
cord-006702-ekf6mja9	660	14	)	)	-RRB-
cord-006702-ekf6mja9	660	15	and	and	CC
cord-006702-ekf6mja9	660	16	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	660	17	(	(	-LRB-
cord-006702-ekf6mja9	660	18	HD	HD	NNP
cord-006702-ekf6mja9	660	19	)	)	-RRB-
cord-006702-ekf6mja9	660	20	groups	group	NNS
cord-006702-ekf6mja9	660	21	,	,	,
cord-006702-ekf6mja9	660	22	respectively	respectively	RB
cord-006702-ekf6mja9	660	23	.	.	.
cord-006702-ekf6mja9	661	1	12	12	CD
cord-006702-ekf6mja9	661	2	had	have	VBD
cord-006702-ekf6mja9	661	3	AP	AP	NNP
cord-006702-ekf6mja9	661	4	,	,	,
cord-006702-ekf6mja9	661	5	7	7	CD
cord-006702-ekf6mja9	661	6	were	be	VBD
cord-006702-ekf6mja9	661	7	treated	treat	VBN
cord-006702-ekf6mja9	661	8	with	with	IN
cord-006702-ekf6mja9	661	9	HD	hd	NN
cord-006702-ekf6mja9	661	10	and	and	CC
cord-006702-ekf6mja9	661	11	5	5	CD
cord-006702-ekf6mja9	661	12	with	with	IN
cord-006702-ekf6mja9	661	13	PD	PD	NNP
cord-006702-ekf6mja9	661	14	.	.	.
cord-006702-ekf6mja9	662	1	The	the	DT
cord-006702-ekf6mja9	662	2	incidence	incidence	NN
cord-006702-ekf6mja9	662	3	rate	rate	NN
cord-006702-ekf6mja9	662	4	of	of	IN
cord-006702-ekf6mja9	662	5	first	first	JJ
cord-006702-ekf6mja9	662	6	-	-	HYPH
cord-006702-ekf6mja9	662	7	time	time	NN
cord-006702-ekf6mja9	662	8	AP	AP	NNP
cord-006702-ekf6mja9	662	9	was	be	VBD
cord-006702-ekf6mja9	662	10	9.5	9.5	CD
cord-006702-ekf6mja9	662	11	per	per	IN
cord-006702-ekf6mja9	662	12	1000	1000	CD
cord-006702-ekf6mja9	662	13	person	person	NN
cord-006702-ekf6mja9	662	14	-	-	HYPH
cord-006702-ekf6mja9	662	15	years	year	NNS
cord-006702-ekf6mja9	662	16	for	for	IN
cord-006702-ekf6mja9	662	17	the	the	DT
cord-006702-ekf6mja9	662	18	overall	overall	JJ
cord-006702-ekf6mja9	662	19	cohort	cohort	NN
cord-006702-ekf6mja9	662	20	,	,	,
cord-006702-ekf6mja9	662	21	6.2/1000	6.2/1000	CD
cord-006702-ekf6mja9	662	22	pers./yrs	pers./yrs	NNP
cord-006702-ekf6mja9	662	23	for	for	IN
cord-006702-ekf6mja9	662	24	PD	PD	NNP
cord-006702-ekf6mja9	662	25	and	and	CC
cord-006702-ekf6mja9	662	26	15.4/1000	15.4/1000	CD
cord-006702-ekf6mja9	662	27	pers./yrs	pers./yrs	NNP
cord-006702-ekf6mja9	662	28	for	for	IN
cord-006702-ekf6mja9	662	29	HD	hd	NN
cord-006702-ekf6mja9	663	1	(	(	-LRB-
cord-006702-ekf6mja9	663	2	p=0.04	p=0.04	NNP
cord-006702-ekf6mja9	663	3	,	,	,
cord-006702-ekf6mja9	663	4	Fisher	Fisher	NNP
cord-006702-ekf6mja9	663	5	's	's	POS
cord-006702-ekf6mja9	663	6	test	test	NN
cord-006702-ekf6mja9	663	7	)	)	-RRB-
cord-006702-ekf6mja9	663	8	.	.	.
cord-006702-ekf6mja9	664	1	The	the	DT
cord-006702-ekf6mja9	664	2	median	median	JJ
cord-006702-ekf6mja9	664	3	age	age	NN
cord-006702-ekf6mja9	664	4	at	at	IN
cord-006702-ekf6mja9	664	5	AP	AP	NNP
cord-006702-ekf6mja9	664	6	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	664	7	was	be	VBD
cord-006702-ekf6mja9	664	8	10	10	CD
cord-006702-ekf6mja9	664	9	yrs	yrs	NN
cord-006702-ekf6mja9	665	1	(	(	-LRB-
cord-006702-ekf6mja9	665	2	range	range	NNP
cord-006702-ekf6mja9	665	3	3	3	CD
cord-006702-ekf6mja9	665	4	-	-	SYM
cord-006702-ekf6mja9	665	5	16	16	CD
cord-006702-ekf6mja9	665	6	)	)	-RRB-
cord-006702-ekf6mja9	665	7	and	and	CC
cord-006702-ekf6mja9	665	8	median	median	JJ
cord-006702-ekf6mja9	665	9	time	time	NN
cord-006702-ekf6mja9	665	10	on	on	IN
cord-006702-ekf6mja9	665	11	dialysis	dialysis	NN
cord-006702-ekf6mja9	665	12	was	be	VBD
cord-006702-ekf6mja9	665	13	11	11	CD
cord-006702-ekf6mja9	665	14	months	month	NNS
cord-006702-ekf6mja9	665	15	(	(	-LRB-
cord-006702-ekf6mja9	665	16	0.5	0.5	CD
cord-006702-ekf6mja9	665	17	-	-	SYM
cord-006702-ekf6mja9	665	18	68	68	CD
cord-006702-ekf6mja9	665	19	)	)	-RRB-
cord-006702-ekf6mja9	665	20	.	.	.
cord-006702-ekf6mja9	666	1	In	in	IN
cord-006702-ekf6mja9	666	2	7	7	CD
cord-006702-ekf6mja9	666	3	pts	pts	NN
cord-006702-ekf6mja9	666	4	(	(	-LRB-
cord-006702-ekf6mja9	666	5	58	58	CD
cord-006702-ekf6mja9	666	6	%	%	NN
cord-006702-ekf6mja9	666	7	)	)	-RRB-
cord-006702-ekf6mja9	666	8	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	666	9	leading	lead	VBG
cord-006702-ekf6mja9	666	10	to	to	IN
cord-006702-ekf6mja9	666	11	ESRD	ESRD	NNP
cord-006702-ekf6mja9	666	12	was	be	VBD
cord-006702-ekf6mja9	666	13	renal	renal	JJ
cord-006702-ekf6mja9	666	14	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	666	15	and	and	CC
cord-006702-ekf6mja9	666	16	6	6	CD
cord-006702-ekf6mja9	666	17	patients	patient	NNS
cord-006702-ekf6mja9	666	18	(	(	-LRB-
cord-006702-ekf6mja9	666	19	50	50	CD
cord-006702-ekf6mja9	666	20	%	%	NN
cord-006702-ekf6mja9	666	21	)	)	-RRB-
cord-006702-ekf6mja9	666	22	were	be	VBD
cord-006702-ekf6mja9	666	23	affected	affect	VBN
cord-006702-ekf6mja9	666	24	by	by	IN
cord-006702-ekf6mja9	666	25	motor	motor	NN
cord-006702-ekf6mja9	666	26	-	-	HYPH
cord-006702-ekf6mja9	666	27	cognitive	cognitive	JJ
cord-006702-ekf6mja9	666	28	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	666	29	.	.	.
cord-006702-ekf6mja9	667	1	All	all	DT
cord-006702-ekf6mja9	667	2	pts	pt	NNS
cord-006702-ekf6mja9	667	3	were	be	VBD
cord-006702-ekf6mja9	667	4	hospitalized	hospitalize	VBN
cord-006702-ekf6mja9	667	5	for	for	IN
cord-006702-ekf6mja9	667	6	a	a	DT
cord-006702-ekf6mja9	667	7	median	median	JJ
cord-006702-ekf6mja9	667	8	time	time	NN
cord-006702-ekf6mja9	667	9	of	of	IN
cord-006702-ekf6mja9	667	10	25	25	CD
cord-006702-ekf6mja9	667	11	days	day	NNS
cord-006702-ekf6mja9	667	12	(	(	-LRB-
cord-006702-ekf6mja9	667	13	2	2	CD
cord-006702-ekf6mja9	667	14	-	-	SYM
cord-006702-ekf6mja9	667	15	180	180	CD
cord-006702-ekf6mja9	667	16	)	)	-RRB-
cord-006702-ekf6mja9	667	17	.	.	.
cord-006702-ekf6mja9	668	1	Median	median	JJ
cord-006702-ekf6mja9	668	2	peak	peak	NN
cord-006702-ekf6mja9	668	3	serum	serum	NN
cord-006702-ekf6mja9	668	4	amylase	amylase	NN
cord-006702-ekf6mja9	668	5	and	and	CC
cord-006702-ekf6mja9	668	6	lipase	lipase	NN
cord-006702-ekf6mja9	668	7	was	be	VBD
cord-006702-ekf6mja9	668	8	1125	1125	CD
cord-006702-ekf6mja9	668	9	UI	UI	NNP
cord-006702-ekf6mja9	668	10	/	/	SYM
cord-006702-ekf6mja9	668	11	L	L	NNP
cord-006702-ekf6mja9	668	12	(	(	-LRB-
cord-006702-ekf6mja9	668	13	234	234	CD
cord-006702-ekf6mja9	668	14	-	-	HYPH
cord-006702-ekf6mja9	668	15	3431	3431	CD
cord-006702-ekf6mja9	668	16	)	)	-RRB-
cord-006702-ekf6mja9	668	17	and	and	CC
cord-006702-ekf6mja9	668	18	2885	2885	CD
cord-006702-ekf6mja9	668	19	UI	UI	NNP
cord-006702-ekf6mja9	668	20	/	/	SYM
cord-006702-ekf6mja9	668	21	L	L	NNP
cord-006702-ekf6mja9	668	22	(	(	-LRB-
cord-006702-ekf6mja9	668	23	612	612	CD
cord-006702-ekf6mja9	668	24	-	-	HYPH
cord-006702-ekf6mja9	668	25	8140	8140	CD
cord-006702-ekf6mja9	668	26	)	)	-RRB-
cord-006702-ekf6mja9	668	27	,	,	,
cord-006702-ekf6mja9	668	28	respectively	respectively	RB
cord-006702-ekf6mja9	668	29	.	.	.
cord-006702-ekf6mja9	669	1	Instrumental	instrumental	JJ
cord-006702-ekf6mja9	669	2	diagnostic	diagnostic	JJ
cord-006702-ekf6mja9	669	3	features	feature	NNS
cord-006702-ekf6mja9	669	4	at	at	IN
cord-006702-ekf6mja9	669	5	presentation	presentation	NN
cord-006702-ekf6mja9	669	6	included	include	VBD
cord-006702-ekf6mja9	669	7	enlarged	enlarged	JJ
cord-006702-ekf6mja9	669	8	pancreas	pancrea	NNS
cord-006702-ekf6mja9	669	9	(	(	-LRB-
cord-006702-ekf6mja9	669	10	80	80	CD
cord-006702-ekf6mja9	669	11	%	%	NN
cord-006702-ekf6mja9	669	12	)	)	-RRB-
cord-006702-ekf6mja9	669	13	and	and	CC
cord-006702-ekf6mja9	669	14	peripancreatic	peripancreatic	JJ
cord-006702-ekf6mja9	669	15	fluid	fluid	JJ
cord-006702-ekf6mja9	669	16	collections	collection	NNS
cord-006702-ekf6mja9	669	17	(	(	-LRB-
cord-006702-ekf6mja9	669	18	33	33	CD
cord-006702-ekf6mja9	669	19	%	%	NN
cord-006702-ekf6mja9	669	20	)	)	-RRB-
cord-006702-ekf6mja9	669	21	.	.	.
cord-006702-ekf6mja9	670	1	In	in	IN
cord-006702-ekf6mja9	670	2	1	1	CD
cord-006702-ekf6mja9	670	3	case	case	NN
cord-006702-ekf6mja9	670	4	,	,	,
cord-006702-ekf6mja9	670	5	AP	AP	NNP
cord-006702-ekf6mja9	670	6	was	be	VBD
cord-006702-ekf6mja9	670	7	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	670	8	shortly	shortly	RB
cord-006702-ekf6mja9	670	9	after	after	IN
cord-006702-ekf6mja9	670	10	an	an	DT
cord-006702-ekf6mja9	670	11	abdominal	abdominal	JJ
cord-006702-ekf6mja9	670	12	surgery	surgery	NN
cord-006702-ekf6mja9	670	13	with	with	IN
cord-006702-ekf6mja9	670	14	exposure	exposure	NN
cord-006702-ekf6mja9	670	15	to	to	IN
cord-006702-ekf6mja9	670	16	propofol	propofol	NN
cord-006702-ekf6mja9	670	17	.	.	.
cord-006702-ekf6mja9	671	1	At	at	IN
cord-006702-ekf6mja9	671	2	AP	AP	NNP
cord-006702-ekf6mja9	671	3	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	671	4	,	,	,
cord-006702-ekf6mja9	671	5	4	4	CD
cord-006702-ekf6mja9	671	6	pts	pt	NNS
cord-006702-ekf6mja9	671	7	were	be	VBD
cord-006702-ekf6mja9	671	8	receiving	receive	VBG
cord-006702-ekf6mja9	671	9	valproic	valproic	JJ
cord-006702-ekf6mja9	671	10	acid	acid	NN
cord-006702-ekf6mja9	671	11	and	and	CC
cord-006702-ekf6mja9	671	12	2	2	CD
cord-006702-ekf6mja9	671	13	pts	pt	NNS
cord-006702-ekf6mja9	671	14	enalapril	enalapril	NN
cord-006702-ekf6mja9	671	15	.	.	.
cord-006702-ekf6mja9	672	1	In	in	IN
cord-006702-ekf6mja9	672	2	3	3	CD
cord-006702-ekf6mja9	672	3	cases	case	NNS
cord-006702-ekf6mja9	672	4	,	,	,
cord-006702-ekf6mja9	672	5	AP	AP	NNP
cord-006702-ekf6mja9	672	6	course	course	NN
cord-006702-ekf6mja9	672	7	was	be	VBD
cord-006702-ekf6mja9	672	8	complicated	complicate	VBN
cord-006702-ekf6mja9	672	9	by	by	IN
cord-006702-ekf6mja9	672	10	a	a	DT
cord-006702-ekf6mja9	672	11	pancreatic	pancreatic	JJ
cord-006702-ekf6mja9	672	12	pseudocyst	pseudocyst	NN
cord-006702-ekf6mja9	672	13	.	.	.
cord-006702-ekf6mja9	673	1	One	one	CD
cord-006702-ekf6mja9	673	2	child	child	NN
cord-006702-ekf6mja9	673	3	required	require	VBD
cord-006702-ekf6mja9	673	4	a	a	DT
cord-006702-ekf6mja9	673	5	shift	shift	NN
cord-006702-ekf6mja9	673	6	from	from	IN
cord-006702-ekf6mja9	673	7	PD	PD	NNP
cord-006702-ekf6mja9	673	8	to	to	IN
cord-006702-ekf6mja9	673	9	HD	hd	NN
cord-006702-ekf6mja9	673	10	because	because	IN
cord-006702-ekf6mja9	673	11	of	of	IN
cord-006702-ekf6mja9	673	12	abdominal	abdominal	JJ
cord-006702-ekf6mja9	673	13	pain	pain	NN
cord-006702-ekf6mja9	673	14	.	.	.
cord-006702-ekf6mja9	674	1	Two	two	CD
cord-006702-ekf6mja9	674	2	pts	pt	NNS
cord-006702-ekf6mja9	674	3	experienced	experience	VBD
cord-006702-ekf6mja9	674	4	recurrent	recurrent	JJ
cord-006702-ekf6mja9	674	5	AP	AP	NNP
cord-006702-ekf6mja9	674	6	,	,	,
cord-006702-ekf6mja9	674	7	while	while	IN
cord-006702-ekf6mja9	674	8	there	there	EX
cord-006702-ekf6mja9	674	9	were	be	VBD
cord-006702-ekf6mja9	674	10	no	no	DT
cord-006702-ekf6mja9	674	11	deaths	death	NNS
cord-006702-ekf6mja9	674	12	related	relate	VBN
cord-006702-ekf6mja9	674	13	to	to	IN
cord-006702-ekf6mja9	674	14	AP	AP	NNP
cord-006702-ekf6mja9	674	15	.	.	.
cord-006702-ekf6mja9	675	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	675	2	:	:	:
cord-006702-ekf6mja9	676	1	In	in	IN
cord-006702-ekf6mja9	676	2	our	-PRON-	PRP$
cord-006702-ekf6mja9	676	3	experience	experience	NN
cord-006702-ekf6mja9	676	4	,	,	,
cord-006702-ekf6mja9	676	5	children	child	NNS
cord-006702-ekf6mja9	676	6	on	on	IN
cord-006702-ekf6mja9	676	7	dialysis	dialysis	NN
cord-006702-ekf6mja9	676	8	show	show	VBP
cord-006702-ekf6mja9	676	9	a	a	DT
cord-006702-ekf6mja9	676	10	significantly	significantly	RB
cord-006702-ekf6mja9	676	11	increased	increase	VBN
cord-006702-ekf6mja9	676	12	risk	risk	NN
cord-006702-ekf6mja9	676	13	for	for	IN
cord-006702-ekf6mja9	676	14	AP	AP	NNP
cord-006702-ekf6mja9	676	15	compared	compare	VBN
cord-006702-ekf6mja9	676	16	with	with	IN
cord-006702-ekf6mja9	676	17	the	the	DT
cord-006702-ekf6mja9	676	18	general	general	JJ
cord-006702-ekf6mja9	676	19	pediatric	pediatric	JJ
cord-006702-ekf6mja9	676	20	population	population	NN
cord-006702-ekf6mja9	676	21	(	(	-LRB-
cord-006702-ekf6mja9	676	22	estimated	estimate	VBN
cord-006702-ekf6mja9	676	23	incidence	incidence	NN
cord-006702-ekf6mja9	676	24	rate	rate	NN
cord-006702-ekf6mja9	676	25	of	of	IN
cord-006702-ekf6mja9	676	26	0.15/1000	0.15/1000	CD
cord-006702-ekf6mja9	676	27	pers./yrs	pers./yrs	NNP
cord-006702-ekf6mja9	676	28	)	)	-RRB-
cord-006702-ekf6mja9	676	29	.	.	.
cord-006702-ekf6mja9	677	1	A	a	DT
cord-006702-ekf6mja9	677	2	higher	high	JJR
cord-006702-ekf6mja9	677	3	incidence	incidence	NN
cord-006702-ekf6mja9	677	4	is	be	VBZ
cord-006702-ekf6mja9	677	5	observed	observe	VBN
cord-006702-ekf6mja9	677	6	in	in	IN
cord-006702-ekf6mja9	677	7	children	child	NNS
cord-006702-ekf6mja9	677	8	on	on	IN
cord-006702-ekf6mja9	677	9	HD	hd	NN
cord-006702-ekf6mja9	677	10	and	and	CC
cord-006702-ekf6mja9	677	11	in	in	IN
cord-006702-ekf6mja9	677	12	those	those	DT
cord-006702-ekf6mja9	677	13	with	with	IN
cord-006702-ekf6mja9	677	14	neurological	neurological	JJ
cord-006702-ekf6mja9	677	15	co	co	NNS
cord-006702-ekf6mja9	677	16	-	-	NNS
cord-006702-ekf6mja9	677	17	morbidities	morbidity	NNS
cord-006702-ekf6mja9	677	18	.	.	.
cord-006702-ekf6mja9	678	1	Objectives	objective	NNS
cord-006702-ekf6mja9	678	2	:	:	:
cord-006702-ekf6mja9	679	1	Bartter	Bartter	NNP
cord-006702-ekf6mja9	679	2	syndrome	syndrome	NN
cord-006702-ekf6mja9	679	3	(	(	-LRB-
cord-006702-ekf6mja9	679	4	BS	BS	NNP
cord-006702-ekf6mja9	679	5	)	)	-RRB-
cord-006702-ekf6mja9	679	6	,	,	,
cord-006702-ekf6mja9	679	7	a	a	DT
cord-006702-ekf6mja9	679	8	normotensive	normotensive	JJ
cord-006702-ekf6mja9	679	9	hypokalemic	hypokalemic	NNP
cord-006702-ekf6mja9	679	10	tubulopathy	tubulopathy	NNP
cord-006702-ekf6mja9	679	11	,	,	,
cord-006702-ekf6mja9	679	12	has	have	VBZ
cord-006702-ekf6mja9	679	13	been	be	VBN
cord-006702-ekf6mja9	679	14	clinically	clinically	RB
cord-006702-ekf6mja9	679	15	known	know	VBN
cord-006702-ekf6mja9	679	16	for	for	IN
cord-006702-ekf6mja9	679	17	decades	decade	NNS
cord-006702-ekf6mja9	679	18	and	and	CC
cord-006702-ekf6mja9	679	19	genotypically	genotypically	RB
cord-006702-ekf6mja9	679	20	characterized	characterize	VBN
cord-006702-ekf6mja9	679	21	.	.	.
cord-006702-ekf6mja9	680	1	As	as	IN
cord-006702-ekf6mja9	680	2	pediatric	pediatric	JJ
cord-006702-ekf6mja9	680	3	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	680	4	and	and	CC
cord-006702-ekf6mja9	680	5	patient	patient	JJ
cord-006702-ekf6mja9	680	6	management	management	NN
cord-006702-ekf6mja9	680	7	improve	improve	NN
cord-006702-ekf6mja9	680	8	,	,	,
cord-006702-ekf6mja9	680	9	more	more	JJR
cord-006702-ekf6mja9	680	10	patients	patient	NNS
cord-006702-ekf6mja9	680	11	survive	survive	VBP
cord-006702-ekf6mja9	680	12	to	to	IN
cord-006702-ekf6mja9	680	13	adulthood	adulthood	NN
cord-006702-ekf6mja9	680	14	,	,	,
cord-006702-ekf6mja9	680	15	potentially	potentially	RB
cord-006702-ekf6mja9	680	16	developing	develop	VBG
cord-006702-ekf6mja9	680	17	new	new	JJ
cord-006702-ekf6mja9	680	18	complications	complication	NNS
cord-006702-ekf6mja9	680	19	.	.	.
cord-006702-ekf6mja9	681	1	We	-PRON-	PRP
cord-006702-ekf6mja9	681	2	summarized	summarize	VBD
cord-006702-ekf6mja9	681	3	our	-PRON-	PRP$
cord-006702-ekf6mja9	681	4	experience	experience	NN
cord-006702-ekf6mja9	681	5	with	with	IN
cord-006702-ekf6mja9	681	6	a	a	DT
cord-006702-ekf6mja9	681	7	group	group	NN
cord-006702-ekf6mja9	681	8	of	of	IN
cord-006702-ekf6mja9	681	9	13	13	CD
cord-006702-ekf6mja9	681	10	young	young	JJ
cord-006702-ekf6mja9	681	11	adults	adult	NNS
cord-006702-ekf6mja9	681	12	with	with	IN
cord-006702-ekf6mja9	681	13	BS	BS	NNP
cord-006702-ekf6mja9	681	14	of	of	IN
cord-006702-ekf6mja9	681	15	2	2	CD
cord-006702-ekf6mja9	681	16	genotypic	genotypic	JJ
cord-006702-ekf6mja9	681	17	variants	variant	NNS
cord-006702-ekf6mja9	681	18	:	:	:
cord-006702-ekf6mja9	681	19	type	type	NN
cord-006702-ekf6mja9	681	20	2	2	CD
cord-006702-ekf6mja9	681	21	,	,	,
cord-006702-ekf6mja9	681	22	due	due	IN
cord-006702-ekf6mja9	681	23	to	to	IN
cord-006702-ekf6mja9	681	24	mutations	mutation	NNS
cord-006702-ekf6mja9	681	25	in	in	IN
cord-006702-ekf6mja9	681	26	ROMK	ROMK	NNP
cord-006702-ekf6mja9	681	27	(	(	-LRB-
cord-006702-ekf6mja9	681	28	BS-2	BS-2	NNP
cord-006702-ekf6mja9	681	29	)	)	-RRB-
cord-006702-ekf6mja9	681	30	and	and	CC
cord-006702-ekf6mja9	681	31	type	type	NN
cord-006702-ekf6mja9	681	32	4	4	CD
cord-006702-ekf6mja9	681	33	,	,	,
cord-006702-ekf6mja9	681	34	due	due	IN
cord-006702-ekf6mja9	681	35	to	to	IN
cord-006702-ekf6mja9	681	36	mutations	mutation	NNS
cord-006702-ekf6mja9	681	37	in	in	IN
cord-006702-ekf6mja9	681	38	the	the	DT
cord-006702-ekf6mja9	681	39	barttin	barttin	NN
cord-006702-ekf6mja9	681	40	gene	gene	NN
cord-006702-ekf6mja9	681	41	(	(	-LRB-
cord-006702-ekf6mja9	681	42	BS-4	BS-4	NNP
cord-006702-ekf6mja9	681	43	)	)	-RRB-
cord-006702-ekf6mja9	681	44	.	.	.
cord-006702-ekf6mja9	682	1	All	all	DT
cord-006702-ekf6mja9	682	2	BS-4	BS-4	NNP
cord-006702-ekf6mja9	682	3	patients	patient	NNS
cord-006702-ekf6mja9	682	4	carry	carry	VBP
cord-006702-ekf6mja9	682	5	the	the	DT
cord-006702-ekf6mja9	682	6	same	same	JJ
cord-006702-ekf6mja9	682	7	mutation	mutation	NN
cord-006702-ekf6mja9	682	8	and	and	CC
cord-006702-ekf6mja9	682	9	belong	belong	VB
cord-006702-ekf6mja9	682	10	to	to	IN
cord-006702-ekf6mja9	682	11	an	an	DT
cord-006702-ekf6mja9	682	12	extended	extended	JJ
cord-006702-ekf6mja9	682	13	family	family	NN
cord-006702-ekf6mja9	682	14	of	of	IN
cord-006702-ekf6mja9	682	15	Arab	arab	JJ
cord-006702-ekf6mja9	682	16	origin	origin	NN
cord-006702-ekf6mja9	682	17	.	.	.
cord-006702-ekf6mja9	683	1	Methods	method	NNS
cord-006702-ekf6mja9	683	2	:	:	:
cord-006702-ekf6mja9	683	3	Medical	medical	JJ
cord-006702-ekf6mja9	683	4	records	record	NNS
cord-006702-ekf6mja9	683	5	were	be	VBD
cord-006702-ekf6mja9	683	6	reviewed	review	VBN
cord-006702-ekf6mja9	683	7	retrospectively	retrospectively	RB
cord-006702-ekf6mja9	683	8	.	.	.
cord-006702-ekf6mja9	684	1	All	all	DT
cord-006702-ekf6mja9	684	2	patients	patient	NNS
cord-006702-ekf6mja9	684	3	have	have	VBP
cord-006702-ekf6mja9	684	4	been	be	VBN
cord-006702-ekf6mja9	684	5	treated	treat	VBN
cord-006702-ekf6mja9	684	6	since	since	IN
cord-006702-ekf6mja9	684	7	infancy	infancy	NN
cord-006702-ekf6mja9	684	8	with	with	IN
cord-006702-ekf6mja9	684	9	standard	standard	NN
cord-006702-ekf6mja9	684	10	of	of	IN
cord-006702-ekf6mja9	684	11	care	care	NN
cord-006702-ekf6mja9	684	12	medications	medication	NNS
cord-006702-ekf6mja9	684	13	,	,	,
cord-006702-ekf6mja9	684	14	including	include	VBG
cord-006702-ekf6mja9	684	15	salts	salt	NNS
cord-006702-ekf6mja9	684	16	(	(	-LRB-
cord-006702-ekf6mja9	684	17	NaCl	nacl	NN
cord-006702-ekf6mja9	684	18	and	and	CC
cord-006702-ekf6mja9	684	19	KCl	KCl	NNP
cord-006702-ekf6mja9	684	20	)	)	-RRB-
cord-006702-ekf6mja9	684	21	supplementation	supplementation	NN
cord-006702-ekf6mja9	684	22	.	.	.
cord-006702-ekf6mja9	685	1	Indomethacin	Indomethacin	NNP
cord-006702-ekf6mja9	685	2	was	be	VBD
cord-006702-ekf6mja9	685	3	administered	administer	VBN
cord-006702-ekf6mja9	685	4	only	only	RB
cord-006702-ekf6mja9	685	5	when	when	WRB
cord-006702-ekf6mja9	685	6	eGFR	egfr	NN
cord-006702-ekf6mja9	685	7	was	be	VBD
cord-006702-ekf6mja9	685	8	normal	normal	JJ
cord-006702-ekf6mja9	685	9	.	.	.
cord-006702-ekf6mja9	686	1	Results	result	NNS
cord-006702-ekf6mja9	686	2	:	:	:
cord-006702-ekf6mja9	687	1	Patients	patient	NNS
cord-006702-ekf6mja9	687	2	(	(	-LRB-
cord-006702-ekf6mja9	687	3	M	M	NNP
cord-006702-ekf6mja9	687	4	:	:	:
cord-006702-ekf6mja9	687	5	F=5:8	F=5:8	NNP
cord-006702-ekf6mja9	687	6	;	;	.
cord-006702-ekf6mja9	688	1	BS-4	BS-4	NNP
cord-006702-ekf6mja9	688	2	:	:	:
cord-006702-ekf6mja9	689	1	BS-2	BS-2	NNP
cord-006702-ekf6mja9	689	2	=	=	NFP
cord-006702-ekf6mja9	689	3	7:6	7:6	CD
cord-006702-ekf6mja9	689	4	)	)	-RRB-
cord-006702-ekf6mja9	689	5	had	have	VBD
cord-006702-ekf6mja9	689	6	an	an	DT
cord-006702-ekf6mja9	689	7	average	average	JJ
cord-006702-ekf6mja9	689	8	age	age	NN
cord-006702-ekf6mja9	689	9	of	of	IN
cord-006702-ekf6mja9	689	10	23.6	23.6	CD
cord-006702-ekf6mja9	689	11	±4.8	±4.8	NNS
cord-006702-ekf6mja9	690	1	(	(	-LRB-
cord-006702-ekf6mja9	690	2	range	range	NNP
cord-006702-ekf6mja9	690	3	18	18	CD
cord-006702-ekf6mja9	690	4	-	-	SYM
cord-006702-ekf6mja9	690	5	37	37	CD
cord-006702-ekf6mja9	690	6	)	)	-RRB-
cord-006702-ekf6mja9	690	7	years	year	NNS
cord-006702-ekf6mja9	690	8	,	,	,
cord-006702-ekf6mja9	690	9	without	without	IN
cord-006702-ekf6mja9	690	10	difference	difference	NN
cord-006702-ekf6mja9	690	11	between	between	IN
cord-006702-ekf6mja9	690	12	the	the	DT
cord-006702-ekf6mja9	690	13	2	2	CD
cord-006702-ekf6mja9	690	14	groups	group	NNS
cord-006702-ekf6mja9	690	15	.	.	.
cord-006702-ekf6mja9	691	1	Most	Most	JJS
cord-006702-ekf6mja9	691	2	of	of	IN
cord-006702-ekf6mja9	691	3	BS-4	BS-4	NNP
cord-006702-ekf6mja9	691	4	vs	vs	IN
cord-006702-ekf6mja9	691	5	none	none	NN
cord-006702-ekf6mja9	691	6	of	of	IN
cord-006702-ekf6mja9	691	7	BS-2	BS-2	NNP
cord-006702-ekf6mja9	691	8	continue	continue	VB
cord-006702-ekf6mja9	691	9	to	to	TO
cord-006702-ekf6mja9	691	10	need	need	VB
cord-006702-ekf6mja9	691	11	oral	oral	JJ
cord-006702-ekf6mja9	691	12	potassium	potassium	NN
cord-006702-ekf6mja9	691	13	supplementation	supplementation	NN
cord-006702-ekf6mja9	691	14	,	,	,
cord-006702-ekf6mja9	691	15	and	and	CC
cord-006702-ekf6mja9	691	16	their	-PRON-	PRP$
cord-006702-ekf6mja9	691	17	potassium	potassium	NN
cord-006702-ekf6mja9	691	18	concentration	concentration	NN
cord-006702-ekf6mja9	691	19	is	be	VBZ
cord-006702-ekf6mja9	691	20	lower	low	JJR
cord-006702-ekf6mja9	691	21	(	(	-LRB-
cord-006702-ekf6mja9	691	22	2.9±0.2	2.9±0.2	CD
cord-006702-ekf6mja9	691	23	vs	vs	IN
cord-006702-ekf6mja9	691	24	3.7±0.3	3.7±0.3	CD
cord-006702-ekf6mja9	691	25	meq	meq	NNP
cord-006702-ekf6mja9	691	26	/	/	SYM
cord-006702-ekf6mja9	691	27	L	L	NNP
cord-006702-ekf6mja9	691	28	in	in	IN
cord-006702-ekf6mja9	692	1	BS-2	BS-2	NNP
cord-006702-ekf6mja9	692	2	,	,	,
cord-006702-ekf6mja9	692	3	p	p	NN
cord-006702-ekf6mja9	692	4	<	<	XX
cord-006702-ekf6mja9	692	5	0.005	0.005	CD
cord-006702-ekf6mja9	692	6	)	)	-RRB-
cord-006702-ekf6mja9	692	7	.	.	.
cord-006702-ekf6mja9	693	1	Mean	mean	JJ
cord-006702-ekf6mja9	693	2	eGFR	egfr	NN
cord-006702-ekf6mja9	693	3	was	be	VBD
cord-006702-ekf6mja9	693	4	not	not	RB
cord-006702-ekf6mja9	693	5	different	different	JJ
cord-006702-ekf6mja9	693	6	between	between	IN
cord-006702-ekf6mja9	693	7	groups	group	NNS
cord-006702-ekf6mja9	693	8	(	(	-LRB-
cord-006702-ekf6mja9	693	9	mean	mean	VB
cord-006702-ekf6mja9	693	10	total	total	NN
cord-006702-ekf6mja9	693	11	:	:	:
cord-006702-ekf6mja9	693	12	95.5±43.9	95.5±43.9	CD
cord-006702-ekf6mja9	693	13	ml	ml	NN
cord-006702-ekf6mja9	693	14	/	/	SYM
cord-006702-ekf6mja9	693	15	min	min	NNP
cord-006702-ekf6mja9	693	16	)	)	-RRB-
cord-006702-ekf6mja9	693	17	,	,	,
cord-006702-ekf6mja9	693	18	but	but	CC
cord-006702-ekf6mja9	694	1	3	3	LS
cord-006702-ekf6mja9	694	2	BS-4	BS-4	NNP
cord-006702-ekf6mja9	694	3	(	(	-LRB-
cord-006702-ekf6mja9	694	4	vs.	vs.	IN
cord-006702-ekf6mja9	694	5	no	no	DT
cord-006702-ekf6mja9	694	6	BS-2	BS-2	NNP
cord-006702-ekf6mja9	694	7	)	)	-RRB-
cord-006702-ekf6mja9	694	8	patients	patient	NNS
cord-006702-ekf6mja9	694	9	had	have	VBD
cord-006702-ekf6mja9	694	10	an	an	DT
cord-006702-ekf6mja9	694	11	eGFR	egfr	NN
cord-006702-ekf6mja9	694	12	<	<	XX
cord-006702-ekf6mja9	694	13	60	60	CD
cord-006702-ekf6mja9	694	14	ml	ml	NN
cord-006702-ekf6mja9	694	15	/	/	SYM
cord-006702-ekf6mja9	694	16	min	min	NN
cord-006702-ekf6mja9	694	17	.	.	.
cord-006702-ekf6mja9	695	1	Mean	mean	JJ
cord-006702-ekf6mja9	695	2	uric	uric	NN
cord-006702-ekf6mja9	695	3	acid	acid	NN
cord-006702-ekf6mja9	695	4	level	level	NN
cord-006702-ekf6mja9	695	5	was	be	VBD
cord-006702-ekf6mja9	695	6	higher	high	JJR
cord-006702-ekf6mja9	695	7	in	in	IN
cord-006702-ekf6mja9	695	8	BS-4	BS-4	NNP
cord-006702-ekf6mja9	695	9	(	(	-LRB-
cord-006702-ekf6mja9	695	10	7.9±3	7.9±3	CD
cord-006702-ekf6mja9	695	11	vs	vs	IN
cord-006702-ekf6mja9	696	1	5.1±0.7	5.1±0.7	NNP
cord-006702-ekf6mja9	696	2	mg	mg	NNP
cord-006702-ekf6mja9	696	3	/	/	SYM
cord-006702-ekf6mja9	696	4	dL	dl	NN
cord-006702-ekf6mja9	696	5	,	,	,
cord-006702-ekf6mja9	696	6	p=0.05	p=0.05	NNP
cord-006702-ekf6mja9	696	7	)	)	-RRB-
cord-006702-ekf6mja9	696	8	.	.	.
cord-006702-ekf6mja9	697	1	Two	two	CD
cord-006702-ekf6mja9	697	2	BS-4	BS-4	NNP
cord-006702-ekf6mja9	697	3	patients	patient	NNS
cord-006702-ekf6mja9	697	4	had	have	VBD
cord-006702-ekf6mja9	697	5	gouty	gouty	JJ
cord-006702-ekf6mja9	697	6	attacks	attack	NNS
cord-006702-ekf6mja9	697	7	.	.	.
cord-006702-ekf6mja9	698	1	No	no	DT
cord-006702-ekf6mja9	698	2	patient	patient	NN
cord-006702-ekf6mja9	698	3	with	with	IN
cord-006702-ekf6mja9	698	4	BS-4	BS-4	NNP
cord-006702-ekf6mja9	698	5	had	have	VBD
cord-006702-ekf6mja9	698	6	hypercalciuria	hypercalciuria	NNS
cord-006702-ekf6mja9	698	7	or	or	CC
cord-006702-ekf6mja9	698	8	nephrocalcinosis	nephrocalcinosis	NNP
cord-006702-ekf6mja9	698	9	,	,	,
cord-006702-ekf6mja9	698	10	compared	compare	VBN
cord-006702-ekf6mja9	698	11	to	to	IN
cord-006702-ekf6mja9	698	12	all	all	DT
cord-006702-ekf6mja9	698	13	BS-2	BS-2	NNP
cord-006702-ekf6mja9	698	14	patients	patient	NNS
cord-006702-ekf6mja9	698	15	with	with	IN
cord-006702-ekf6mja9	698	16	these	these	DT
cord-006702-ekf6mja9	698	17	complications	complication	NNS
cord-006702-ekf6mja9	698	18	.	.	.
cord-006702-ekf6mja9	699	1	Three	three	CD
cord-006702-ekf6mja9	699	2	BS-2	BS-2	NNP
cord-006702-ekf6mja9	699	3	also	also	RB
cord-006702-ekf6mja9	699	4	had	have	VBD
cord-006702-ekf6mja9	699	5	symptomatic	symptomatic	JJ
cord-006702-ekf6mja9	699	6	nephrolithiasis	nephrolithiasis	NN
cord-006702-ekf6mja9	699	7	.	.	.
cord-006702-ekf6mja9	700	1	Serum	serum	NN
cord-006702-ekf6mja9	700	2	PTH	PTH	NNP
cord-006702-ekf6mja9	700	3	levels	level	NNS
cord-006702-ekf6mja9	700	4	were	be	VBD
cord-006702-ekf6mja9	700	5	mildly	mildly	RB
cord-006702-ekf6mja9	700	6	increased	increase	VBN
cord-006702-ekf6mja9	700	7	in	in	IN
cord-006702-ekf6mja9	700	8	both	both	DT
cord-006702-ekf6mja9	700	9	groups	group	NNS
cord-006702-ekf6mja9	700	10	(	(	-LRB-
cord-006702-ekf6mja9	700	11	121±60.1	121±60.1	CD
cord-006702-ekf6mja9	700	12	and	and	CC
cord-006702-ekf6mja9	700	13	212±77.8	212±77.8	CD
cord-006702-ekf6mja9	700	14	pg	pg	NNP
cord-006702-ekf6mja9	700	15	/	/	SYM
cord-006702-ekf6mja9	700	16	ml	ml	XX
cord-006702-ekf6mja9	700	17	in	in	IN
cord-006702-ekf6mja9	700	18	BS-4	BS-4	NNP
cord-006702-ekf6mja9	700	19	and	and	CC
cord-006702-ekf6mja9	700	20	-2	-2	NNP
cord-006702-ekf6mja9	700	21	respectively	respectively	RB
cord-006702-ekf6mja9	700	22	,	,	,
cord-006702-ekf6mja9	700	23	p=0.057	p=0.057	NNP
cord-006702-ekf6mja9	700	24	)	)	-RRB-
cord-006702-ekf6mja9	700	25	.	.	.
cord-006702-ekf6mja9	701	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	701	2	:	:	:
cord-006702-ekf6mja9	702	1	Young	young	JJ
cord-006702-ekf6mja9	702	2	adults	adult	NNS
cord-006702-ekf6mja9	702	3	with	with	IN
cord-006702-ekf6mja9	702	4	BS-4	BS-4	NNP
cord-006702-ekf6mja9	702	5	and	and	CC
cord-006702-ekf6mja9	702	6	BS-2	BS-2	NNP
cord-006702-ekf6mja9	702	7	display	display	VB
cord-006702-ekf6mja9	702	8	a	a	DT
cord-006702-ekf6mja9	702	9	phenotypic	phenotypic	JJ
cord-006702-ekf6mja9	702	10	variability	variability	NN
cord-006702-ekf6mja9	702	11	:	:	:
cord-006702-ekf6mja9	702	12	decreased	decrease	VBN
cord-006702-ekf6mja9	702	13	eGFR	egfr	NN
cord-006702-ekf6mja9	702	14	was	be	VBD
cord-006702-ekf6mja9	702	15	seen	see	VBN
cord-006702-ekf6mja9	702	16	only	only	RB
cord-006702-ekf6mja9	702	17	in	in	IN
cord-006702-ekf6mja9	702	18	BS-4	BS-4	NNP
cord-006702-ekf6mja9	702	19	,	,	,
cord-006702-ekf6mja9	702	20	in	in	IN
cord-006702-ekf6mja9	702	21	association	association	NN
cord-006702-ekf6mja9	702	22	with	with	IN
cord-006702-ekf6mja9	702	23	persistent	persistent	JJ
cord-006702-ekf6mja9	702	24	hypokalemia	hypokalemia	NN
cord-006702-ekf6mja9	702	25	,	,	,
cord-006702-ekf6mja9	702	26	hyperuricemia	hyperuricemia	NN
cord-006702-ekf6mja9	702	27	and	and	CC
cord-006702-ekf6mja9	702	28	gout	gout	NN
cord-006702-ekf6mja9	702	29	.	.	.
cord-006702-ekf6mja9	703	1	BS-2	BS-2	NNP
cord-006702-ekf6mja9	703	2	patients	patient	NNS
cord-006702-ekf6mja9	703	3	showed	show	VBD
cord-006702-ekf6mja9	703	4	a	a	DT
cord-006702-ekf6mja9	703	5	preserved	preserve	VBN
cord-006702-ekf6mja9	703	6	eGFR	egfr	JJ
cord-006702-ekf6mja9	703	7	and	and	CC
cord-006702-ekf6mja9	703	8	normal	normal	JJ
cord-006702-ekf6mja9	703	9	potassium	potassium	NN
cord-006702-ekf6mja9	703	10	levels	level	NNS
cord-006702-ekf6mja9	703	11	(	(	-LRB-
cord-006702-ekf6mja9	703	12	despite	despite	IN
cord-006702-ekf6mja9	703	13	less	less	JJR
cord-006702-ekf6mja9	703	14	need	need	NN
cord-006702-ekf6mja9	703	15	for	for	IN
cord-006702-ekf6mja9	703	16	drug	drug	NN
cord-006702-ekf6mja9	703	17	therapy	therapy	NN
cord-006702-ekf6mja9	703	18	)	)	-RRB-
cord-006702-ekf6mja9	703	19	,	,	,
cord-006702-ekf6mja9	703	20	but	but	CC
cord-006702-ekf6mja9	703	21	more	more	RBR
cord-006702-ekf6mja9	703	22	significant	significant	JJ
cord-006702-ekf6mja9	703	23	hypercalciuria	hypercalciuria	NN
cord-006702-ekf6mja9	703	24	and	and	CC
cord-006702-ekf6mja9	703	25	nephrocalcinosis	nephrocalcinosis	NN
cord-006702-ekf6mja9	703	26	,	,	,
cord-006702-ekf6mja9	703	27	with	with	IN
cord-006702-ekf6mja9	703	28	several	several	JJ
cord-006702-ekf6mja9	703	29	cases	case	NNS
cord-006702-ekf6mja9	703	30	of	of	IN
cord-006702-ekf6mja9	703	31	symptomatic	symptomatic	JJ
cord-006702-ekf6mja9	703	32	nephrolithiasis	nephrolithiasis	NN
cord-006702-ekf6mja9	703	33	.	.	.
cord-006702-ekf6mja9	704	1	Objectives	objective	NNS
cord-006702-ekf6mja9	704	2	:	:	:
cord-006702-ekf6mja9	704	3	Socio	socio	JJ
cord-006702-ekf6mja9	704	4	-	-	HYPH
cord-006702-ekf6mja9	704	5	economic	economic	JJ
cord-006702-ekf6mja9	704	6	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	704	7	is	be	VBZ
cord-006702-ekf6mja9	704	8	increasingly	increasingly	RB
cord-006702-ekf6mja9	704	9	recognised	recognise	VBN
cord-006702-ekf6mja9	704	10	as	as	IN
cord-006702-ekf6mja9	704	11	an	an	DT
cord-006702-ekf6mja9	704	12	important	important	JJ
cord-006702-ekf6mja9	704	13	risk	risk	NN
cord-006702-ekf6mja9	704	14	factor	factor	NN
cord-006702-ekf6mja9	704	15	for	for	IN
cord-006702-ekf6mja9	704	16	chronic	chronic	JJ
cord-006702-ekf6mja9	704	17	disease	disease	NN
cord-006702-ekf6mja9	704	18	,	,	,
cord-006702-ekf6mja9	704	19	but	but	CC
cord-006702-ekf6mja9	704	20	the	the	DT
cord-006702-ekf6mja9	704	21	strength	strength	NN
cord-006702-ekf6mja9	704	22	of	of	IN
cord-006702-ekf6mja9	704	23	the	the	DT
cord-006702-ekf6mja9	704	24	association	association	NN
cord-006702-ekf6mja9	704	25	with	with	IN
cord-006702-ekf6mja9	704	26	the	the	DT
cord-006702-ekf6mja9	704	27	development	development	NN
cord-006702-ekf6mja9	704	28	of	of	IN
cord-006702-ekf6mja9	704	29	chronic	chronic	JJ
cord-006702-ekf6mja9	704	30	kidney	kidney	NN
cord-006702-ekf6mja9	704	31	disease	disease	NN
cord-006702-ekf6mja9	704	32	(	(	-LRB-
cord-006702-ekf6mja9	704	33	CKD	CKD	NNP
cord-006702-ekf6mja9	704	34	)	)	-RRB-
cord-006702-ekf6mja9	704	35	and	and	CC
cord-006702-ekf6mja9	704	36	the	the	DT
cord-006702-ekf6mja9	704	37	contribution	contribution	NN
cord-006702-ekf6mja9	704	38	of	of	IN
cord-006702-ekf6mja9	704	39	the	the	DT
cord-006702-ekf6mja9	704	40	various	various	JJ
cord-006702-ekf6mja9	704	41	domains	domain	NNS
cord-006702-ekf6mja9	704	42	of	of	IN
cord-006702-ekf6mja9	704	43	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	704	44	are	be	VBP
cord-006702-ekf6mja9	704	45	uncertain	uncertain	JJ
cord-006702-ekf6mja9	704	46	.	.	.
cord-006702-ekf6mja9	705	1	The	the	DT
cord-006702-ekf6mja9	705	2	aim	aim	NN
cord-006702-ekf6mja9	705	3	of	of	IN
cord-006702-ekf6mja9	705	4	this	this	DT
cord-006702-ekf6mja9	705	5	study	study	NN
cord-006702-ekf6mja9	705	6	was	be	VBD
cord-006702-ekf6mja9	705	7	to	to	TO
cord-006702-ekf6mja9	705	8	synthesise	synthesise	VB
cord-006702-ekf6mja9	705	9	the	the	DT
cord-006702-ekf6mja9	705	10	evidence	evidence	NN
cord-006702-ekf6mja9	705	11	regarding	regard	VBG
cord-006702-ekf6mja9	705	12	the	the	DT
cord-006702-ekf6mja9	705	13	risk	risk	NN
cord-006702-ekf6mja9	705	14	of	of	IN
cord-006702-ekf6mja9	705	15	CKD	CKD	NNP
cord-006702-ekf6mja9	705	16	and	and	CC
cord-006702-ekf6mja9	705	17	end	end	VB
cord-006702-ekf6mja9	705	18	stage	stage	NN
cord-006702-ekf6mja9	705	19	kidney	kidney	NN
cord-006702-ekf6mja9	705	20	disease	disease	NN
cord-006702-ekf6mja9	705	21	(	(	-LRB-
cord-006702-ekf6mja9	705	22	ESKD	ESKD	NNP
cord-006702-ekf6mja9	705	23	)	)	-RRB-
cord-006702-ekf6mja9	705	24	in	in	IN
cord-006702-ekf6mja9	705	25	the	the	DT
cord-006702-ekf6mja9	705	26	general	general	JJ
cord-006702-ekf6mja9	705	27	population	population	NN
cord-006702-ekf6mja9	705	28	according	accord	VBG
cord-006702-ekf6mja9	705	29	to	to	IN
cord-006702-ekf6mja9	705	30	markers	marker	NNS
cord-006702-ekf6mja9	705	31	of	of	IN
cord-006702-ekf6mja9	705	32	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	705	33	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	705	34	.	.	.
cord-006702-ekf6mja9	706	1	Methods	method	NNS
cord-006702-ekf6mja9	706	2	:	:	:
cord-006702-ekf6mja9	706	3	We	-PRON-	PRP
cord-006702-ekf6mja9	706	4	performed	perform	VBD
cord-006702-ekf6mja9	706	5	a	a	DT
cord-006702-ekf6mja9	706	6	systematic	systematic	JJ
cord-006702-ekf6mja9	706	7	review	review	NN
cord-006702-ekf6mja9	706	8	and	and	CC
cord-006702-ekf6mja9	706	9	meta	meta	NNP
cord-006702-ekf6mja9	706	10	-	-	HYPH
cord-006702-ekf6mja9	706	11	analysis	analysis	NN
cord-006702-ekf6mja9	706	12	with	with	IN
cord-006702-ekf6mja9	706	13	risk	risk	NN
cord-006702-ekf6mja9	706	14	of	of	IN
cord-006702-ekf6mja9	706	15	bias	bias	NN
cord-006702-ekf6mja9	706	16	was	be	VBD
cord-006702-ekf6mja9	706	17	assessed	assess	VBN
cord-006702-ekf6mja9	706	18	using	use	VBG
cord-006702-ekf6mja9	706	19	the	the	DT
cord-006702-ekf6mja9	706	20	Newcastle	Newcastle	NNP
cord-006702-ekf6mja9	706	21	Ottawa	Ottawa	NNP
cord-006702-ekf6mja9	706	22	Scale	Scale	NNP
cord-006702-ekf6mja9	706	23	and	and	CC
cord-006702-ekf6mja9	706	24	summary	summary	NN
cord-006702-ekf6mja9	706	25	effects	effect	NNS
cord-006702-ekf6mja9	706	26	were	be	VBD
cord-006702-ekf6mja9	706	27	estimated	estimate	VBN
cord-006702-ekf6mja9	706	28	using	use	VBG
cord-006702-ekf6mja9	706	29	random	random	JJ
cord-006702-ekf6mja9	706	30	effects	effect	NNS
cord-006702-ekf6mja9	706	31	meta	meta	NN
cord-006702-ekf6mja9	706	32	-	-	HYPH
cord-006702-ekf6mja9	706	33	analysis	analysis	NNP
cord-006702-ekf6mja9	706	34	and	and	CC
cord-006702-ekf6mja9	706	35	meta	meta	JJ
cord-006702-ekf6mja9	706	36	-	-	HYPH
cord-006702-ekf6mja9	706	37	regression	regression	NN
cord-006702-ekf6mja9	706	38	.	.	.
cord-006702-ekf6mja9	707	1	We	-PRON-	PRP
cord-006702-ekf6mja9	707	2	included	include	VBD
cord-006702-ekf6mja9	707	3	published	publish	VBN
cord-006702-ekf6mja9	707	4	primary	primary	JJ
cord-006702-ekf6mja9	707	5	articles	article	NNS
cord-006702-ekf6mja9	707	6	in	in	IN
cord-006702-ekf6mja9	707	7	MEDLINE	MEDLINE	NNP
cord-006702-ekf6mja9	707	8	,	,	,
cord-006702-ekf6mja9	707	9	EMBASE	EMBASE	NNP
cord-006702-ekf6mja9	707	10	or	or	CC
cord-006702-ekf6mja9	707	11	CINAHL	CINAHL	NNP
cord-006702-ekf6mja9	707	12	(	(	-LRB-
cord-006702-ekf6mja9	707	13	until	until	IN
cord-006702-ekf6mja9	707	14	December	December	NNP
cord-006702-ekf6mja9	707	15	2014	2014	CD
cord-006702-ekf6mja9	707	16	)	)	-RRB-
cord-006702-ekf6mja9	707	17	that	that	WDT
cord-006702-ekf6mja9	707	18	were	be	VBD
cord-006702-ekf6mja9	707	19	cohort	cohort	JJ
cord-006702-ekf6mja9	707	20	studies	study	NNS
cord-006702-ekf6mja9	707	21	conducted	conduct	VBN
cord-006702-ekf6mja9	707	22	in	in	IN
cord-006702-ekf6mja9	707	23	the	the	DT
cord-006702-ekf6mja9	707	24	general	general	JJ
cord-006702-ekf6mja9	707	25	population	population	NN
cord-006702-ekf6mja9	707	26	.	.	.
cord-006702-ekf6mja9	708	1	We	-PRON-	PRP
cord-006702-ekf6mja9	708	2	included	include	VBD
cord-006702-ekf6mja9	708	3	studies	study	NNS
cord-006702-ekf6mja9	708	4	investigating	investigate	VBG
cord-006702-ekf6mja9	708	5	the	the	DT
cord-006702-ekf6mja9	708	6	risk	risk	NN
cord-006702-ekf6mja9	708	7	of	of	IN
cord-006702-ekf6mja9	708	8	incident	incident	NN
cord-006702-ekf6mja9	708	9	CKD	CKD	NNP
cord-006702-ekf6mja9	708	10	(	(	-LRB-
cord-006702-ekf6mja9	708	11	and	and	CC
cord-006702-ekf6mja9	708	12	stage	stage	NN
cord-006702-ekf6mja9	708	13	)	)	-RRB-
cord-006702-ekf6mja9	708	14	and	and	CC
cord-006702-ekf6mja9	708	15	any	any	DT
cord-006702-ekf6mja9	708	16	of	of	IN
cord-006702-ekf6mja9	708	17	the	the	DT
cord-006702-ekf6mja9	708	18	following	follow	VBG
cord-006702-ekf6mja9	708	19	social	social	JJ
cord-006702-ekf6mja9	708	20	determinants	determinant	NNS
cord-006702-ekf6mja9	708	21	:	:	:
cord-006702-ekf6mja9	708	22	ethnicity	ethnicity	NN
cord-006702-ekf6mja9	708	23	,	,	,
cord-006702-ekf6mja9	708	24	education	education	NN
cord-006702-ekf6mja9	708	25	,	,	,
cord-006702-ekf6mja9	708	26	income	income	NN
cord-006702-ekf6mja9	708	27	,	,	,
cord-006702-ekf6mja9	708	28	occupation	occupation	NN
cord-006702-ekf6mja9	708	29	and	and	CC
cord-006702-ekf6mja9	708	30	area	area	NN
cord-006702-ekf6mja9	708	31	level	level	NN
cord-006702-ekf6mja9	708	32	measures	measure	NNS
cord-006702-ekf6mja9	708	33	of	of	IN
cord-006702-ekf6mja9	708	34	socio	socio	JJ
cord-006702-ekf6mja9	708	35	-	-	HYPH
cord-006702-ekf6mja9	708	36	economic	economic	JJ
cord-006702-ekf6mja9	708	37	status	status	NN
cord-006702-ekf6mja9	708	38	.	.	.
cord-006702-ekf6mja9	709	1	Results	result	NNS
cord-006702-ekf6mja9	709	2	:	:	:
cord-006702-ekf6mja9	710	1	We	-PRON-	PRP
cord-006702-ekf6mja9	710	2	identified	identify	VBD
cord-006702-ekf6mja9	710	3	21	21	CD
cord-006702-ekf6mja9	710	4	studies	study	NNS
cord-006702-ekf6mja9	710	5	(	(	-LRB-
cord-006702-ekf6mja9	710	6	n=12,987,147	n=12,987,147	``
cord-006702-ekf6mja9	710	7	)	)	-RRB-
cord-006702-ekf6mja9	710	8	-13	-13	NNS
cord-006702-ekf6mja9	710	9	investigated	investigate	VBN
cord-006702-ekf6mja9	710	10	risk	risk	NN
cord-006702-ekf6mja9	710	11	by	by	IN
cord-006702-ekf6mja9	710	12	ethnicity	ethnicity	NN
cord-006702-ekf6mja9	710	13	,	,	,
cord-006702-ekf6mja9	710	14	education	education	NN
cord-006702-ekf6mja9	710	15	(	(	-LRB-
cord-006702-ekf6mja9	710	16	9	9	CD
cord-006702-ekf6mja9	710	17	)	)	-RRB-
cord-006702-ekf6mja9	710	18	,	,	,
cord-006702-ekf6mja9	710	19	income	income	NN
cord-006702-ekf6mja9	710	20	(	(	-LRB-
cord-006702-ekf6mja9	710	21	6	6	CD
cord-006702-ekf6mja9	710	22	)	)	-RRB-
cord-006702-ekf6mja9	710	23	,	,	,
cord-006702-ekf6mja9	710	24	area	area	NN
cord-006702-ekf6mja9	710	25	level	level	NN
cord-006702-ekf6mja9	710	26	socio	socio	JJ
cord-006702-ekf6mja9	710	27	-	-	HYPH
cord-006702-ekf6mja9	710	28	economic	economic	JJ
cord-006702-ekf6mja9	710	29	status	status	NN
cord-006702-ekf6mja9	710	30	(	(	-LRB-
cord-006702-ekf6mja9	710	31	4	4	CD
cord-006702-ekf6mja9	710	32	)	)	-RRB-
cord-006702-ekf6mja9	710	33	and	and	CC
cord-006702-ekf6mja9	710	34	occupation	occupation	NN
cord-006702-ekf6mja9	710	35	(	(	-LRB-
cord-006702-ekf6mja9	710	36	2	2	CD
cord-006702-ekf6mja9	710	37	)	)	-RRB-
cord-006702-ekf6mja9	710	38	.	.	.
cord-006702-ekf6mja9	711	1	Only	only	RB
cord-006702-ekf6mja9	711	2	two	two	CD
cord-006702-ekf6mja9	711	3	of	of	IN
cord-006702-ekf6mja9	711	4	the	the	DT
cord-006702-ekf6mja9	711	5	included	include	VBN
cord-006702-ekf6mja9	711	6	studies	study	NNS
cord-006702-ekf6mja9	711	7	were	be	VBD
cord-006702-ekf6mja9	711	8	of	of	IN
cord-006702-ekf6mja9	711	9	high	high	JJ
cord-006702-ekf6mja9	711	10	risk	risk	NN
cord-006702-ekf6mja9	711	11	of	of	IN
cord-006702-ekf6mja9	711	12	bias	bias	NN
cord-006702-ekf6mja9	711	13	.	.	.
cord-006702-ekf6mja9	712	1	Black	Black	NNP
cord-006702-ekf6mja9	712	2	Americans	Americans	NNPS
cord-006702-ekf6mja9	712	3	have	have	VBP
cord-006702-ekf6mja9	712	4	more	more	JJR
cord-006702-ekf6mja9	712	5	than	than	IN
cord-006702-ekf6mja9	712	6	double	double	PDT
cord-006702-ekf6mja9	712	7	the	the	DT
cord-006702-ekf6mja9	712	8	risk	risk	NN
cord-006702-ekf6mja9	712	9	of	of	IN
cord-006702-ekf6mja9	712	10	ESKD	ESKD	NNP
cord-006702-ekf6mja9	712	11	compared	compare	VBN
cord-006702-ekf6mja9	712	12	to	to	IN
cord-006702-ekf6mja9	712	13	white	white	JJ
cord-006702-ekf6mja9	712	14	Americans	Americans	NNPS
cord-006702-ekf6mja9	712	15	(	(	-LRB-
cord-006702-ekf6mja9	712	16	hazard	hazard	NN
cord-006702-ekf6mja9	712	17	ratio	ratio	NN
cord-006702-ekf6mja9	712	18	2.33	2.33	CD
cord-006702-ekf6mja9	712	19	,	,	,
cord-006702-ekf6mja9	712	20	95	95	CD
cord-006702-ekf6mja9	712	21	%	%	NN
cord-006702-ekf6mja9	712	22	confidence	confidence	NN
cord-006702-ekf6mja9	712	23	interval	interval	NN
cord-006702-ekf6mja9	712	24	2.02	2.02	CD
cord-006702-ekf6mja9	712	25	to	to	IN
cord-006702-ekf6mja9	712	26	2.63	2.63	CD
cord-006702-ekf6mja9	712	27	,	,	,
cord-006702-ekf6mja9	712	28	I	-PRON-	PRP
cord-006702-ekf6mja9	712	29	2	2	CD
cord-006702-ekf6mja9	712	30	59	59	CD
cord-006702-ekf6mja9	712	31	%	%	NN
cord-006702-ekf6mja9	712	32	)	)	-RRB-
cord-006702-ekf6mja9	712	33	.	.	.
cord-006702-ekf6mja9	713	1	Low	low	JJ
cord-006702-ekf6mja9	713	2	income	income	NN
cord-006702-ekf6mja9	713	3	was	be	VBD
cord-006702-ekf6mja9	713	4	found	find	VBN
cord-006702-ekf6mja9	713	5	to	to	TO
cord-006702-ekf6mja9	713	6	increase	increase	VB
cord-006702-ekf6mja9	713	7	risk	risk	NN
cord-006702-ekf6mja9	713	8	of	of	IN
cord-006702-ekf6mja9	713	9	ESKD	ESKD	NNP
cord-006702-ekf6mja9	713	10	in	in	IN
cord-006702-ekf6mja9	713	11	four	four	CD
cord-006702-ekf6mja9	713	12	of	of	IN
cord-006702-ekf6mja9	713	13	the	the	DT
cord-006702-ekf6mja9	713	14	six	six	CD
cord-006702-ekf6mja9	713	15	studies	study	NNS
cord-006702-ekf6mja9	713	16	identified	identify	VBN
cord-006702-ekf6mja9	713	17	,	,	,
cord-006702-ekf6mja9	713	18	however	however	RB
cord-006702-ekf6mja9	713	19	low	low	JJ
cord-006702-ekf6mja9	713	20	education	education	NN
cord-006702-ekf6mja9	713	21	and	and	CC
cord-006702-ekf6mja9	713	22	low	low	JJ
cord-006702-ekf6mja9	713	23	SES	SES	NNP
cord-006702-ekf6mja9	713	24	were	be	VBD
cord-006702-ekf6mja9	713	25	not	not	RB
cord-006702-ekf6mja9	713	26	consistently	consistently	RB
cord-006702-ekf6mja9	713	27	identified	identify	VBN
cord-006702-ekf6mja9	713	28	as	as	IN
cord-006702-ekf6mja9	713	29	risk	risk	NN
cord-006702-ekf6mja9	713	30	factors	factor	NNS
cord-006702-ekf6mja9	713	31	for	for	IN
cord-006702-ekf6mja9	713	32	CKD	CKD	NNP
cord-006702-ekf6mja9	713	33	.	.	.
cord-006702-ekf6mja9	714	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	714	2	:	:	:
cord-006702-ekf6mja9	715	1	Although	although	IN
cord-006702-ekf6mja9	715	2	there	there	EX
cord-006702-ekf6mja9	715	3	is	be	VBZ
cord-006702-ekf6mja9	715	4	a	a	DT
cord-006702-ekf6mja9	715	5	substantial	substantial	JJ
cord-006702-ekf6mja9	715	6	body	body	NN
cord-006702-ekf6mja9	715	7	of	of	IN
cord-006702-ekf6mja9	715	8	evidence	evidence	NN
cord-006702-ekf6mja9	715	9	regarding	regard	VBG
cord-006702-ekf6mja9	715	10	the	the	DT
cord-006702-ekf6mja9	715	11	association	association	NN
cord-006702-ekf6mja9	715	12	between	between	IN
cord-006702-ekf6mja9	715	13	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	715	14	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	715	15	and	and	CC
cord-006702-ekf6mja9	715	16	CKD	CKD	NNP
cord-006702-ekf6mja9	715	17	,	,	,
cord-006702-ekf6mja9	715	18	there	there	EX
cord-006702-ekf6mja9	715	19	appears	appear	VBZ
cord-006702-ekf6mja9	715	20	to	to	TO
cord-006702-ekf6mja9	715	21	be	be	VB
cord-006702-ekf6mja9	715	22	an	an	DT
cord-006702-ekf6mja9	715	23	inconsistent	inconsistent	JJ
cord-006702-ekf6mja9	715	24	relationship	relationship	NN
cord-006702-ekf6mja9	715	25	.	.	.
cord-006702-ekf6mja9	716	1	This	this	DT
cord-006702-ekf6mja9	716	2	may	may	MD
cord-006702-ekf6mja9	716	3	be	be	VB
cord-006702-ekf6mja9	716	4	artefactual	artefactual	JJ
cord-006702-ekf6mja9	716	5	,	,	,
cord-006702-ekf6mja9	716	6	due	due	IN
cord-006702-ekf6mja9	716	7	to	to	IN
cord-006702-ekf6mja9	716	8	difficulties	difficulty	NNS
cord-006702-ekf6mja9	716	9	in	in	IN
cord-006702-ekf6mja9	716	10	quantifying	quantify	VBG
cord-006702-ekf6mja9	716	11	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	716	12	,	,	,
cord-006702-ekf6mja9	716	13	or	or	CC
cord-006702-ekf6mja9	716	14	reflect	reflect	VB
cord-006702-ekf6mja9	716	15	true	true	JJ
cord-006702-ekf6mja9	716	16	underlying	underlying	JJ
cord-006702-ekf6mja9	716	17	differences	difference	NNS
cord-006702-ekf6mja9	716	18	in	in	IN
cord-006702-ekf6mja9	716	19	the	the	DT
cord-006702-ekf6mja9	716	20	association	association	NN
cord-006702-ekf6mja9	716	21	across	across	IN
cord-006702-ekf6mja9	716	22	different	different	JJ
cord-006702-ekf6mja9	716	23	settings	setting	NNS
cord-006702-ekf6mja9	716	24	.	.	.
cord-006702-ekf6mja9	717	1	Quality	quality	NN
cord-006702-ekf6mja9	717	2	of	of	IN
cord-006702-ekf6mja9	717	3	life	life	NN
cord-006702-ekf6mja9	717	4	and	and	CC
cord-006702-ekf6mja9	717	5	its	-PRON-	PRP$
cord-006702-ekf6mja9	717	6	determinants	determinant	NNS
cord-006702-ekf6mja9	717	7	of	of	IN
cord-006702-ekf6mja9	717	8	children	child	NNS
cord-006702-ekf6mja9	717	9	on	on	IN
cord-006702-ekf6mja9	717	10	renal	renal	JJ
cord-006702-ekf6mja9	717	11	replacement	replacement	NN
cord-006702-ekf6mja9	717	12	therapy	therapy	NN
cord-006702-ekf6mja9	717	13	:	:	:
cord-006702-ekf6mja9	717	14	a	a	DT
cord-006702-ekf6mja9	717	15	multicentre	multicentre	NNP
cord-006702-ekf6mja9	717	16	study	study	NN
cord-006702-ekf6mja9	717	17	L.	L.	NNP
cord-006702-ekf6mja9	717	18	Tjaden	Tjaden	NNP
cord-006702-ekf6mja9	717	19	(	(	-LRB-
cord-006702-ekf6mja9	717	20	1	1	CD
cord-006702-ekf6mja9	717	21	)	)	-RRB-
cord-006702-ekf6mja9	717	22	,	,	,
cord-006702-ekf6mja9	717	23	A.	A.	NNP
cord-006702-ekf6mja9	717	24	Splinter	Splinter	NNP
cord-006702-ekf6mja9	717	25	(	(	-LRB-
cord-006702-ekf6mja9	717	26	2	2	CD
cord-006702-ekf6mja9	717	27	)	)	-RRB-
cord-006702-ekf6mja9	717	28	,	,	,
cord-006702-ekf6mja9	717	29	K.	K.	NNP
cord-006702-ekf6mja9	717	30	Cransberg	Cransberg	NNP
cord-006702-ekf6mja9	717	31	(	(	-LRB-
cord-006702-ekf6mja9	717	32	3	3	CD
cord-006702-ekf6mja9	717	33	)	)	-RRB-
cord-006702-ekf6mja9	717	34	,	,	,
cord-006702-ekf6mja9	717	35	L.	L.	NNP
cord-006702-ekf6mja9	717	36	Koster	Koster	NNP
cord-006702-ekf6mja9	717	37	-	-	HYPH
cord-006702-ekf6mja9	717	38	kamphuis	kamphuis	NNP
cord-006702-ekf6mja9	717	39	(	(	-LRB-
cord-006702-ekf6mja9	717	40	4	4	CD
cord-006702-ekf6mja9	717	41	)	)	-RRB-
cord-006702-ekf6mja9	717	42	,	,	,
cord-006702-ekf6mja9	717	43	A.	A.	NNP
cord-006702-ekf6mja9	717	44	Raes	Raes	NNP
cord-006702-ekf6mja9	717	45	(	(	-LRB-
cord-006702-ekf6mja9	717	46	5	5	CD
cord-006702-ekf6mja9	717	47	)	)	-RRB-
cord-006702-ekf6mja9	717	48	,	,	,
cord-006702-ekf6mja9	717	49	C.	C.	NNP
cord-006702-ekf6mja9	717	50	Taylan	Taylan	NNP
cord-006702-ekf6mja9	717	51	(	(	-LRB-
cord-006702-ekf6mja9	717	52	6	6	CD
cord-006702-ekf6mja9	717	53	)	)	-RRB-
cord-006702-ekf6mja9	717	54	,	,	,
cord-006702-ekf6mja9	717	55	M.	M.	NNP
cord-006702-ekf6mja9	717	56	Grootenhuis	Grootenhuis	NNP
cord-006702-ekf6mja9	717	57	(	(	-LRB-
cord-006702-ekf6mja9	717	58	2	2	CD
cord-006702-ekf6mja9	717	59	)	)	-RRB-
cord-006702-ekf6mja9	717	60	,	,	,
cord-006702-ekf6mja9	717	61	J.	J.	NNP
cord-006702-ekf6mja9	717	62	Groothoff	Groothoff	NNP
cord-006702-ekf6mja9	717	63	(	(	-LRB-
cord-006702-ekf6mja9	717	64	 	 	_SP
cord-006702-ekf6mja9	717	65	Objectives	objective	NNS
cord-006702-ekf6mja9	717	66	:	:	:
cord-006702-ekf6mja9	718	1	To	to	TO
cord-006702-ekf6mja9	718	2	assess	assess	VB
cord-006702-ekf6mja9	718	3	health	health	NN
cord-006702-ekf6mja9	718	4	-	-	HYPH
cord-006702-ekf6mja9	718	5	related	relate	VBN
cord-006702-ekf6mja9	718	6	quality	quality	NN
cord-006702-ekf6mja9	718	7	of	of	IN
cord-006702-ekf6mja9	718	8	life	life	NN
cord-006702-ekf6mja9	718	9	(	(	-LRB-
cord-006702-ekf6mja9	718	10	HRQoL	HRQoL	NNP
cord-006702-ekf6mja9	718	11	)	)	-RRB-
cord-006702-ekf6mja9	718	12	across	across	IN
cord-006702-ekf6mja9	718	13	three	three	CD
cord-006702-ekf6mja9	718	14	renal	renal	JJ
cord-006702-ekf6mja9	718	15	replacement	replacement	NN
cord-006702-ekf6mja9	718	16	therapy	therapy	NN
cord-006702-ekf6mja9	718	17	modalities	modality	NNS
cord-006702-ekf6mja9	718	18	(	(	-LRB-
cord-006702-ekf6mja9	718	19	preemptive	preemptive	JJ
cord-006702-ekf6mja9	718	20	transplant	transplant	NN
cord-006702-ekf6mja9	718	21	,	,	,
cord-006702-ekf6mja9	718	22	non	non	JJ
cord-006702-ekf6mja9	718	23	-	-	JJ
cord-006702-ekf6mja9	718	24	preemptive	preemptive	JJ
cord-006702-ekf6mja9	718	25	transplant	transplant	NN
cord-006702-ekf6mja9	718	26	and	and	CC
cord-006702-ekf6mja9	718	27	dialysis	dialysis	NN
cord-006702-ekf6mja9	718	28	)	)	-RRB-
cord-006702-ekf6mja9	718	29	in	in	IN
cord-006702-ekf6mja9	718	30	comparison	comparison	NN
cord-006702-ekf6mja9	718	31	with	with	IN
cord-006702-ekf6mja9	718	32	the	the	DT
cord-006702-ekf6mja9	718	33	healthy	healthy	JJ
cord-006702-ekf6mja9	718	34	norm	norm	NN
cord-006702-ekf6mja9	718	35	and	and	CC
cord-006702-ekf6mja9	718	36	other	other	JJ
cord-006702-ekf6mja9	718	37	chronic	chronic	JJ
cord-006702-ekf6mja9	718	38	disease	disease	NN
cord-006702-ekf6mja9	718	39	cohorts	cohort	NNS
cord-006702-ekf6mja9	718	40	,	,	,
cord-006702-ekf6mja9	718	41	and	and	CC
cord-006702-ekf6mja9	718	42	to	to	TO
cord-006702-ekf6mja9	718	43	explore	explore	VB
cord-006702-ekf6mja9	718	44	which	which	WDT
cord-006702-ekf6mja9	718	45	patient	patient	NN
cord-006702-ekf6mja9	718	46	factors	factor	NNS
cord-006702-ekf6mja9	718	47	are	be	VBP
cord-006702-ekf6mja9	718	48	related	relate	VBN
cord-006702-ekf6mja9	718	49	to	to	IN
cord-006702-ekf6mja9	718	50	HRQoL.	HRQoL.	NNP
cord-006702-ekf6mja9	718	51	Methods	method	NNS
cord-006702-ekf6mja9	718	52	:	:	:
cord-006702-ekf6mja9	718	53	All	all	DT
cord-006702-ekf6mja9	718	54	prevalent	prevalent	JJ
cord-006702-ekf6mja9	718	55	end	end	NN
cord-006702-ekf6mja9	718	56	stage	stage	NN
cord-006702-ekf6mja9	718	57	renal	renal	JJ
cord-006702-ekf6mja9	718	58	disease	disease	NN
cord-006702-ekf6mja9	718	59	(	(	-LRB-
cord-006702-ekf6mja9	718	60	ESRD	ESRD	NNP
cord-006702-ekf6mja9	718	61	)	)	-RRB-
cord-006702-ekf6mja9	718	62	patients	patient	NNS
cord-006702-ekf6mja9	718	63	aged	aged	JJ
cord-006702-ekf6mja9	718	64	8	8	CD
cord-006702-ekf6mja9	718	65	-	-	SYM
cord-006702-ekf6mja9	718	66	18	18	CD
cord-006702-ekf6mja9	718	67	years	year	NNS
cord-006702-ekf6mja9	718	68	in	in	IN
cord-006702-ekf6mja9	718	69	the	the	DT
cord-006702-ekf6mja9	718	70	Netherlands	Netherlands	NNP
cord-006702-ekf6mja9	718	71	,	,	,
cord-006702-ekf6mja9	718	72	Belgium	Belgium	NNP
cord-006702-ekf6mja9	718	73	and	and	CC
cord-006702-ekf6mja9	718	74	part	part	NN
cord-006702-ekf6mja9	718	75	of	of	IN
cord-006702-ekf6mja9	718	76	Germany	Germany	NNP
cord-006702-ekf6mja9	718	77	were	be	VBD
cord-006702-ekf6mja9	718	78	approached	approach	VBN
cord-006702-ekf6mja9	718	79	to	to	TO
cord-006702-ekf6mja9	718	80	complete	complete	VB
cord-006702-ekf6mja9	718	81	the	the	DT
cord-006702-ekf6mja9	718	82	Paediatric	Paediatric	NNP
cord-006702-ekf6mja9	718	83	Quality	Quality	NNP
cord-006702-ekf6mja9	718	84	of	of	IN
cord-006702-ekf6mja9	718	85	Life	Life	NNP
cord-006702-ekf6mja9	718	86	Inventory	Inventory	NNP
cord-006702-ekf6mja9	718	87	4.0	4.0	CD
cord-006702-ekf6mja9	718	88	(	(	-LRB-
cord-006702-ekf6mja9	718	89	PedsQL	PedsQL	NNP
cord-006702-ekf6mja9	718	90	™	™	NN
cord-006702-ekf6mja9	718	91	)	)	-RRB-
cord-006702-ekf6mja9	718	92	questionnaire	questionnaire	NN
cord-006702-ekf6mja9	718	93	.	.	.
cord-006702-ekf6mja9	719	1	We	-PRON-	PRP
cord-006702-ekf6mja9	719	2	determined	determine	VBD
cord-006702-ekf6mja9	719	3	differences	difference	NNS
cord-006702-ekf6mja9	719	4	between	between	IN
cord-006702-ekf6mja9	719	5	groups	group	NNS
cord-006702-ekf6mja9	719	6	on	on	IN
cord-006702-ekf6mja9	719	7	PedsQL	PedsQL	NNP
cord-006702-ekf6mja9	719	8	™	™	VBP
cord-006702-ekf6mja9	719	9	mean	mean	JJ
cord-006702-ekf6mja9	719	10	scores	score	NNS
cord-006702-ekf6mja9	719	11	,	,	,
cord-006702-ekf6mja9	719	12	and	and	CC
cord-006702-ekf6mja9	719	13	the	the	DT
cord-006702-ekf6mja9	719	14	proportion	proportion	NN
cord-006702-ekf6mja9	719	15	of	of	IN
cord-006702-ekf6mja9	719	16	children	child	NNS
cord-006702-ekf6mja9	719	17	with	with	IN
cord-006702-ekf6mja9	719	18	an	an	DT
cord-006702-ekf6mja9	719	19	impaired	impaired	JJ
cord-006702-ekf6mja9	719	20	HRQoL	HRQoL	NNP
cord-006702-ekf6mja9	719	21	(	(	-LRB-
cord-006702-ekf6mja9	719	22	≥1	≥1	WRB
cord-006702-ekf6mja9	719	23	SD	SD	NNP
cord-006702-ekf6mja9	719	24	lower	low	JJR
cord-006702-ekf6mja9	719	25	than	than	IN
cord-006702-ekf6mja9	719	26	the	the	DT
cord-006702-ekf6mja9	719	27	healthy	healthy	JJ
cord-006702-ekf6mja9	719	28	norm	norm	NN
cord-006702-ekf6mja9	719	29	)	)	-RRB-
cord-006702-ekf6mja9	719	30	.	.	.
cord-006702-ekf6mja9	720	1	Linear	linear	JJ
cord-006702-ekf6mja9	720	2	regression	regression	NN
cord-006702-ekf6mja9	720	3	models	model	NNS
cord-006702-ekf6mja9	720	4	were	be	VBD
cord-006702-ekf6mja9	720	5	used	use	VBN
cord-006702-ekf6mja9	720	6	to	to	TO
cord-006702-ekf6mja9	720	7	explore	explore	VB
cord-006702-ekf6mja9	720	8	determinants	determinant	NNS
cord-006702-ekf6mja9	720	9	of	of	IN
cord-006702-ekf6mja9	720	10	HRQoL.	hrqol.	JJ
cord-006702-ekf6mja9	720	11	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	720	12	:	:	:
cord-006702-ekf6mja9	720	13	This	this	DT
cord-006702-ekf6mja9	720	14	is	be	VBZ
cord-006702-ekf6mja9	720	15	the	the	DT
cord-006702-ekf6mja9	720	16	first	first	JJ
cord-006702-ekf6mja9	720	17	international	international	JJ
cord-006702-ekf6mja9	720	18	study	study	NN
cord-006702-ekf6mja9	720	19	examining	examine	VBG
cord-006702-ekf6mja9	720	20	HRQoL	HRQoL	NNP
cord-006702-ekf6mja9	720	21	in	in	IN
cord-006702-ekf6mja9	720	22	the	the	DT
cord-006702-ekf6mja9	720	23	paediatric	paediatric	JJ
cord-006702-ekf6mja9	720	24	ESRD	ESRD	NNP
cord-006702-ekf6mja9	720	25	population	population	NN
cord-006702-ekf6mja9	720	26	.	.	.
cord-006702-ekf6mja9	721	1	We	-PRON-	PRP
cord-006702-ekf6mja9	721	2	found	find	VBD
cord-006702-ekf6mja9	721	3	important	important	JJ
cord-006702-ekf6mja9	721	4	decrements	decrement	NNS
cord-006702-ekf6mja9	721	5	in	in	IN
cord-006702-ekf6mja9	721	6	HRQoL	HRQoL	NNP
cord-006702-ekf6mja9	721	7	in	in	IN
cord-006702-ekf6mja9	721	8	this	this	DT
cord-006702-ekf6mja9	721	9	specific	specific	JJ
cord-006702-ekf6mja9	721	10	population	population	NN
cord-006702-ekf6mja9	721	11	,	,	,
cord-006702-ekf6mja9	721	12	even	even	RB
cord-006702-ekf6mja9	721	13	after	after	IN
cord-006702-ekf6mja9	721	14	successful	successful	JJ
cord-006702-ekf6mja9	721	15	transplantation	transplantation	NN
cord-006702-ekf6mja9	721	16	.	.	.
cord-006702-ekf6mja9	722	1	Physicians	physician	NNS
cord-006702-ekf6mja9	722	2	should	should	MD
cord-006702-ekf6mja9	722	3	be	be	VB
cord-006702-ekf6mja9	722	4	aware	aware	JJ
cord-006702-ekf6mja9	722	5	of	of	IN
cord-006702-ekf6mja9	722	6	the	the	DT
cord-006702-ekf6mja9	722	7	impact	impact	NN
cord-006702-ekf6mja9	722	8	on	on	IN
cord-006702-ekf6mja9	722	9	social	social	JJ
cord-006702-ekf6mja9	722	10	development	development	NN
cord-006702-ekf6mja9	722	11	and	and	CC
cord-006702-ekf6mja9	722	12	academic	academic	JJ
cord-006702-ekf6mja9	722	13	performance	performance	NN
cord-006702-ekf6mja9	722	14	of	of	IN
cord-006702-ekf6mja9	722	15	paediatric	paediatric	JJ
cord-006702-ekf6mja9	722	16	renal	renal	JJ
cord-006702-ekf6mja9	722	17	transplant	transplant	NN
cord-006702-ekf6mja9	722	18	recipients	recipient	NNS
cord-006702-ekf6mja9	722	19	and	and	CC
cord-006702-ekf6mja9	722	20	adjust	adjust	VB
cord-006702-ekf6mja9	722	21	their	-PRON-	PRP$
cord-006702-ekf6mja9	722	22	practice	practice	NN
cord-006702-ekf6mja9	722	23	where	where	WRB
cord-006702-ekf6mja9	722	24	possible	possible	JJ
cord-006702-ekf6mja9	722	25	in	in	IN
cord-006702-ekf6mja9	722	26	order	order	NN
cord-006702-ekf6mja9	722	27	to	to	TO
cord-006702-ekf6mja9	722	28	improve	improve	VB
cord-006702-ekf6mja9	722	29	autonomy	autonomy	NN
cord-006702-ekf6mja9	722	30	development	development	NN
cord-006702-ekf6mja9	722	31	.	.	.
cord-006702-ekf6mja9	723	1	Furthermore	furthermore	RB
cord-006702-ekf6mja9	723	2	,	,	,
cord-006702-ekf6mja9	723	3	to	to	TO
cord-006702-ekf6mja9	723	4	develop	develop	VB
cord-006702-ekf6mja9	723	5	tailored	tailor	VBN
cord-006702-ekf6mja9	723	6	interventions	intervention	NNS
cord-006702-ekf6mja9	723	7	for	for	IN
cord-006702-ekf6mja9	723	8	children	child	NNS
cord-006702-ekf6mja9	723	9	with	with	IN
cord-006702-ekf6mja9	723	10	ESRD	ESRD	NNP
cord-006702-ekf6mja9	723	11	,	,	,
cord-006702-ekf6mja9	723	12	qualitative	qualitative	JJ
cord-006702-ekf6mja9	723	13	studies	study	NNS
cord-006702-ekf6mja9	723	14	are	be	VBP
cord-006702-ekf6mja9	723	15	needed	need	VBN
cord-006702-ekf6mja9	723	16	to	to	TO
cord-006702-ekf6mja9	723	17	gain	gain	VB
cord-006702-ekf6mja9	723	18	more	more	JJR
cord-006702-ekf6mja9	723	19	insight	insight	NN
cord-006702-ekf6mja9	723	20	in	in	IN
cord-006702-ekf6mja9	723	21	the	the	DT
cord-006702-ekf6mja9	723	22	predictors	predictor	NNS
cord-006702-ekf6mja9	723	23	of	of	IN
cord-006702-ekf6mja9	723	24	HRQoL.	HRQoL.	NNP
cord-006702-ekf6mja9	723	25	Disease	Disease	NNP
cord-006702-ekf6mja9	723	26	(	(	-LRB-
cord-006702-ekf6mja9	723	27	the	the	DT
cord-006702-ekf6mja9	723	28	K	K	NNP
cord-006702-ekf6mja9	723	29	-	-	HYPH
cord-006702-ekf6mja9	723	30	CAD	CAD	NNP
cord-006702-ekf6mja9	723	31	study	study	NN
cord-006702-ekf6mja9	723	32	)	)	-RRB-
cord-006702-ekf6mja9	724	1	M.	M.	NNP
cord-006702-ekf6mja9	724	2	Didsbury	Didsbury	NNP
cord-006702-ekf6mja9	724	3	(	(	-LRB-
cord-006702-ekf6mja9	724	4	1	1	CD
cord-006702-ekf6mja9	724	5	)	)	-RRB-
cord-006702-ekf6mja9	724	6	,	,	,
cord-006702-ekf6mja9	724	7	J.	J.	NNP
cord-006702-ekf6mja9	724	8	Craig	Craig	NNP
cord-006702-ekf6mja9	724	9	(	(	-LRB-
cord-006702-ekf6mja9	724	10	1	1	CD
cord-006702-ekf6mja9	724	11	)	)	-RRB-
cord-006702-ekf6mja9	724	12	,	,	,
cord-006702-ekf6mja9	724	13	A.	A.	NNP
cord-006702-ekf6mja9	724	14	Van	Van	NNP
cord-006702-ekf6mja9	724	15	Zwieten	Zwieten	NNP
cord-006702-ekf6mja9	724	16	(	(	-LRB-
cord-006702-ekf6mja9	724	17	1	1	CD
cord-006702-ekf6mja9	724	18	)	)	-RRB-
cord-006702-ekf6mja9	725	1	Objectives	objective	NNS
cord-006702-ekf6mja9	725	2	:	:	:
cord-006702-ekf6mja9	725	3	Poverty	poverty	NN
cord-006702-ekf6mja9	725	4	and	and	CC
cord-006702-ekf6mja9	725	5	social	social	JJ
cord-006702-ekf6mja9	725	6	inequality	inequality	NN
cord-006702-ekf6mja9	725	7	are	be	VBP
cord-006702-ekf6mja9	725	8	major	major	JJ
cord-006702-ekf6mja9	725	9	barriers	barrier	NNS
cord-006702-ekf6mja9	725	10	for	for	IN
cord-006702-ekf6mja9	725	11	achieving	achieve	VBG
cord-006702-ekf6mja9	725	12	optimal	optimal	JJ
cord-006702-ekf6mja9	725	13	health	health	NN
cord-006702-ekf6mja9	725	14	outcomes	outcome	NNS
cord-006702-ekf6mja9	725	15	in	in	IN
cord-006702-ekf6mja9	725	16	children	child	NNS
cord-006702-ekf6mja9	725	17	,	,	,
cord-006702-ekf6mja9	725	18	but	but	CC
cord-006702-ekf6mja9	725	19	their	-PRON-	PRP$
cord-006702-ekf6mja9	725	20	impact	impact	NN
cord-006702-ekf6mja9	725	21	on	on	IN
cord-006702-ekf6mja9	725	22	outcomes	outcome	NNS
cord-006702-ekf6mja9	725	23	in	in	IN
cord-006702-ekf6mja9	725	24	children	child	NNS
cord-006702-ekf6mja9	725	25	with	with	IN
cord-006702-ekf6mja9	725	26	chronic	chronic	JJ
cord-006702-ekf6mja9	725	27	kidney	kidney	NN
cord-006702-ekf6mja9	725	28	disease	disease	NN
cord-006702-ekf6mja9	725	29	(	(	-LRB-
cord-006702-ekf6mja9	725	30	CKD	CKD	NNP
cord-006702-ekf6mja9	725	31	)	)	-RRB-
cord-006702-ekf6mja9	725	32	is	be	VBZ
cord-006702-ekf6mja9	725	33	unclear	unclear	JJ
cord-006702-ekf6mja9	725	34	.	.	.
cord-006702-ekf6mja9	726	1	The	the	DT
cord-006702-ekf6mja9	726	2	K	K	NNP
cord-006702-ekf6mja9	726	3	-	-	HYPH
cord-006702-ekf6mja9	726	4	CAD	CAD	NNP
cord-006702-ekf6mja9	726	5	study	study	NN
cord-006702-ekf6mja9	726	6	is	be	VBZ
cord-006702-ekf6mja9	726	7	an	an	DT
cord-006702-ekf6mja9	726	8	Australian	australian	JJ
cord-006702-ekf6mja9	726	9	and	and	CC
cord-006702-ekf6mja9	726	10	New	New	NNP
cord-006702-ekf6mja9	726	11	Zealand	Zealand	NNP
cord-006702-ekf6mja9	726	12	multicentre	multicentre	NNP
cord-006702-ekf6mja9	726	13	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	726	14	cohort	cohort	NN
cord-006702-ekf6mja9	726	15	study	study	NN
cord-006702-ekf6mja9	726	16	that	that	WDT
cord-006702-ekf6mja9	726	17	aims	aim	VBZ
cord-006702-ekf6mja9	726	18	to	to	TO
cord-006702-ekf6mja9	726	19	describe	describe	VB
cord-006702-ekf6mja9	726	20	the	the	DT
cord-006702-ekf6mja9	726	21	prevalence	prevalence	NN
cord-006702-ekf6mja9	726	22	of	of	IN
cord-006702-ekf6mja9	726	23	economic	economic	JJ
cord-006702-ekf6mja9	726	24	hardship	hardship	NN
cord-006702-ekf6mja9	726	25	among	among	IN
cord-006702-ekf6mja9	726	26	caregivers	caregiver	NNS
cord-006702-ekf6mja9	726	27	and	and	CC
cord-006702-ekf6mja9	726	28	to	to	TO
cord-006702-ekf6mja9	726	29	determine	determine	VB
cord-006702-ekf6mja9	726	30	the	the	DT
cord-006702-ekf6mja9	726	31	relationship	relationship	NN
cord-006702-ekf6mja9	726	32	between	between	IN
cord-006702-ekf6mja9	726	33	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	726	34	status	status	NN
cord-006702-ekf6mja9	726	35	of	of	IN
cord-006702-ekf6mja9	726	36	caregivers	caregiver	NNS
cord-006702-ekf6mja9	726	37	and	and	CC
cord-006702-ekf6mja9	726	38	self	self	NN
cord-006702-ekf6mja9	726	39	-	-	HYPH
cord-006702-ekf6mja9	726	40	rated	rate	VBN
cord-006702-ekf6mja9	726	41	health	health	NN
cord-006702-ekf6mja9	726	42	of	of	IN
cord-006702-ekf6mja9	726	43	children	child	NNS
cord-006702-ekf6mja9	726	44	with	with	IN
cord-006702-ekf6mja9	726	45	CKD	CKD	NNP
cord-006702-ekf6mja9	726	46	.	.	.
cord-006702-ekf6mja9	727	1	Methods	method	NNS
cord-006702-ekf6mja9	727	2	:	:	:
cord-006702-ekf6mja9	728	1	Two	two	CD
cord-006702-ekf6mja9	728	2	hundred	hundred	CD
cord-006702-ekf6mja9	728	3	and	and	CC
cord-006702-ekf6mja9	728	4	ninety	ninety	CD
cord-006702-ekf6mja9	728	5	-	-	HYPH
cord-006702-ekf6mja9	728	6	three	three	CD
cord-006702-ekf6mja9	728	7	children	child	NNS
cord-006702-ekf6mja9	728	8	aged	age	VBN
cord-006702-ekf6mja9	728	9	6	6	CD
cord-006702-ekf6mja9	728	10	-	-	SYM
cord-006702-ekf6mja9	728	11	18	18	CD
cord-006702-ekf6mja9	728	12	years	year	NNS
cord-006702-ekf6mja9	728	13	with	with	IN
cord-006702-ekf6mja9	728	14	CKD	CKD	NNP
cord-006702-ekf6mja9	728	15	[	[	-LRB-
cord-006702-ekf6mja9	728	16	stage	stage	NN
cord-006702-ekf6mja9	728	17	1	1	CD
cord-006702-ekf6mja9	728	18	-	-	SYM
cord-006702-ekf6mja9	728	19	2	2	CD
cord-006702-ekf6mja9	728	20	(	(	-LRB-
cord-006702-ekf6mja9	728	21	n=69	n=69	NNP
cord-006702-ekf6mja9	728	22	)	)	-RRB-
cord-006702-ekf6mja9	728	23	,	,	,
cord-006702-ekf6mja9	728	24	stage	stage	NN
cord-006702-ekf6mja9	728	25	3	3	CD
cord-006702-ekf6mja9	728	26	-	-	SYM
cord-006702-ekf6mja9	728	27	5	5	CD
cord-006702-ekf6mja9	728	28	(	(	-LRB-
cord-006702-ekf6mja9	728	29	n=77	n=77	RB
cord-006702-ekf6mja9	728	30	)	)	-RRB-
cord-006702-ekf6mja9	728	31	,	,	,
cord-006702-ekf6mja9	728	32	dialysis	dialysis	NN
cord-006702-ekf6mja9	728	33	(	(	-LRB-
cord-006702-ekf6mja9	728	34	n=35	n=35	NNP
cord-006702-ekf6mja9	728	35	)	)	-RRB-
cord-006702-ekf6mja9	728	36	,	,	,
cord-006702-ekf6mja9	728	37	transplant	transplant	NN
cord-006702-ekf6mja9	728	38	(	(	-LRB-
cord-006702-ekf6mja9	728	39	n=112	n=112	NNP
cord-006702-ekf6mja9	728	40	)	)	-RRB-
cord-006702-ekf6mja9	728	41	]	]	-RRB-
cord-006702-ekf6mja9	728	42	were	be	VBD
cord-006702-ekf6mja9	728	43	recruited	recruit	VBN
cord-006702-ekf6mja9	728	44	from	from	IN
cord-006702-ekf6mja9	728	45	four	four	CD
cord-006702-ekf6mja9	728	46	children	child	NNS
cord-006702-ekf6mja9	728	47	's	's	POS
cord-006702-ekf6mja9	728	48	hospitals	hospital	NNS
cord-006702-ekf6mja9	728	49	across	across	IN
cord-006702-ekf6mja9	728	50	Australia	Australia	NNP
cord-006702-ekf6mja9	728	51	.	.	.
cord-006702-ekf6mja9	729	1	Comparisons	comparison	NNS
cord-006702-ekf6mja9	729	2	by	by	IN
cord-006702-ekf6mja9	729	3	quintile	quintile	NN
cord-006702-ekf6mja9	729	4	of	of	IN
cord-006702-ekf6mja9	729	5	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	729	6	status	status	NN
cord-006702-ekf6mja9	729	7	for	for	IN
cord-006702-ekf6mja9	729	8	nominal	nominal	JJ
cord-006702-ekf6mja9	729	9	self	self	NN
cord-006702-ekf6mja9	729	10	-	-	HYPH
cord-006702-ekf6mja9	729	11	rated	rate	VBN
cord-006702-ekf6mja9	729	12	health	health	NN
cord-006702-ekf6mja9	729	13	outcomes	outcome	NNS
cord-006702-ekf6mja9	729	14	among	among	IN
cord-006702-ekf6mja9	729	15	children	child	NNS
cord-006702-ekf6mja9	729	16	with	with	IN
cord-006702-ekf6mja9	729	17	CKD	CKD	NNP
cord-006702-ekf6mja9	729	18	were	be	VBD
cord-006702-ekf6mja9	729	19	analysed	analyse	VBN
cord-006702-ekf6mja9	729	20	using	use	VBG
cord-006702-ekf6mja9	729	21	adjusted	adjust	VBN
cord-006702-ekf6mja9	729	22	multinomial	multinomial	JJ
cord-006702-ekf6mja9	729	23	logistic	logistic	JJ
cord-006702-ekf6mja9	729	24	regression	regression	NN
cord-006702-ekf6mja9	729	25	.	.	.
cord-006702-ekf6mja9	730	1	Results	result	NNS
cord-006702-ekf6mja9	730	2	:	:	:
cord-006702-ekf6mja9	731	1	The	the	DT
cord-006702-ekf6mja9	731	2	mean	mean	JJ
cord-006702-ekf6mja9	731	3	ages	age	NNS
cord-006702-ekf6mja9	731	4	of	of	IN
cord-006702-ekf6mja9	731	5	the	the	DT
cord-006702-ekf6mja9	731	6	caregivers	caregiver	NNS
cord-006702-ekf6mja9	731	7	and	and	CC
cord-006702-ekf6mja9	731	8	children	child	NNS
cord-006702-ekf6mja9	731	9	were	be	VBD
cord-006702-ekf6mja9	731	10	43.5	43.5	CD
cord-006702-ekf6mja9	731	11	years	year	NNS
cord-006702-ekf6mja9	731	12	(	(	-LRB-
cord-006702-ekf6mja9	731	13	SD	sd	NN
cord-006702-ekf6mja9	731	14	:	:	:
cord-006702-ekf6mja9	731	15	8.0	8.0	CD
cord-006702-ekf6mja9	731	16	)	)	-RRB-
cord-006702-ekf6mja9	731	17	and	and	CC
cord-006702-ekf6mja9	731	18	12.5	12.5	CD
cord-006702-ekf6mja9	731	19	(	(	-LRB-
cord-006702-ekf6mja9	731	20	SD:3.9	sd:3.9	UH
cord-006702-ekf6mja9	731	21	)	)	-RRB-
cord-006702-ekf6mja9	731	22	,	,	,
cord-006702-ekf6mja9	731	23	respectively	respectively	RB
cord-006702-ekf6mja9	731	24	.	.	.
cord-006702-ekf6mja9	732	1	More	More	JJR
cord-006702-ekf6mja9	732	2	than	than	IN
cord-006702-ekf6mja9	732	3	50	50	CD
cord-006702-ekf6mja9	732	4	%	%	NN
cord-006702-ekf6mja9	732	5	of	of	IN
cord-006702-ekf6mja9	732	6	all	all	DT
cord-006702-ekf6mja9	732	7	households	household	NNS
cord-006702-ekf6mja9	732	8	earned	earn	VBD
cord-006702-ekf6mja9	732	9	less	less	JJR
cord-006702-ekf6mja9	732	10	than	than	IN
cord-006702-ekf6mja9	732	11	$	$	$
cord-006702-ekf6mja9	732	12	1250AUD	1250aud	CD
cord-006702-ekf6mja9	732	13	per	per	IN
cord-006702-ekf6mja9	732	14	week	week	NN
cord-006702-ekf6mja9	732	15	.	.	.
cord-006702-ekf6mja9	733	1	Only	only	RB
cord-006702-ekf6mja9	733	2	20	20	CD
cord-006702-ekf6mja9	733	3	%	%	NN
cord-006702-ekf6mja9	733	4	(	(	-LRB-
cord-006702-ekf6mja9	733	5	n=60	n=60	JJ
cord-006702-ekf6mja9	733	6	)	)	-RRB-
cord-006702-ekf6mja9	733	7	of	of	IN
cord-006702-ekf6mja9	733	8	caregivers	caregiver	NNS
cord-006702-ekf6mja9	733	9	engaged	engage	VBN
cord-006702-ekf6mja9	733	10	in	in	IN
cord-006702-ekf6mja9	733	11	fulltime	fulltime	JJ
cord-006702-ekf6mja9	733	12	employment	employment	NN
cord-006702-ekf6mja9	733	13	and	and	CC
cord-006702-ekf6mja9	733	14	30	30	CD
cord-006702-ekf6mja9	733	15	%	%	NN
cord-006702-ekf6mja9	733	16	(	(	-LRB-
cord-006702-ekf6mja9	733	17	n=89	n=89	NN
cord-006702-ekf6mja9	733	18	)	)	-RRB-
cord-006702-ekf6mja9	733	19	had	have	VBD
cord-006702-ekf6mja9	733	20	completed	complete	VBN
cord-006702-ekf6mja9	733	21	tertiary	tertiary	JJ
cord-006702-ekf6mja9	733	22	education	education	NN
cord-006702-ekf6mja9	733	23	.	.	.
cord-006702-ekf6mja9	734	1	Across	across	IN
cord-006702-ekf6mja9	734	2	the	the	DT
cord-006702-ekf6mja9	734	3	cohort	cohort	NN
cord-006702-ekf6mja9	734	4	,	,	,
cord-006702-ekf6mja9	734	5	carers	carer	NNS
cord-006702-ekf6mja9	734	6	who	who	WP
cord-006702-ekf6mja9	734	7	reported	report	VBD
cord-006702-ekf6mja9	734	8	higher	high	JJR
cord-006702-ekf6mja9	734	9	levels	level	NNS
cord-006702-ekf6mja9	734	10	of	of	IN
cord-006702-ekf6mja9	734	11	financial	financial	JJ
cord-006702-ekf6mja9	734	12	difficulty	difficulty	NN
cord-006702-ekf6mja9	734	13	were	be	VBD
cord-006702-ekf6mja9	734	14	twice	twice	RB
cord-006702-ekf6mja9	734	15	as	as	RB
cord-006702-ekf6mja9	734	16	likely	likely	JJ
cord-006702-ekf6mja9	734	17	to	to	TO
cord-006702-ekf6mja9	734	18	report	report	VB
cord-006702-ekf6mja9	734	19	that	that	IN
cord-006702-ekf6mja9	734	20	their	-PRON-	PRP$
cord-006702-ekf6mja9	734	21	child	child	NN
cord-006702-ekf6mja9	734	22	's	's	POS
cord-006702-ekf6mja9	734	23	health	health	NN
cord-006702-ekf6mja9	734	24	was	be	VBD
cord-006702-ekf6mja9	734	25	poor	poor	JJ
cord-006702-ekf6mja9	734	26	than	than	IN
cord-006702-ekf6mja9	734	27	those	those	DT
cord-006702-ekf6mja9	734	28	with	with	IN
cord-006702-ekf6mja9	734	29	lower	low	JJR
cord-006702-ekf6mja9	734	30	levels	level	NNS
cord-006702-ekf6mja9	734	31	of	of	IN
cord-006702-ekf6mja9	734	32	financial	financial	JJ
cord-006702-ekf6mja9	734	33	difficulty	difficulty	NN
cord-006702-ekf6mja9	735	1	(	(	-LRB-
cord-006702-ekf6mja9	735	2	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	735	3	:	:	:
cord-006702-ekf6mja9	736	1	Socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	736	2	status	status	NN
cord-006702-ekf6mja9	736	3	of	of	IN
cord-006702-ekf6mja9	736	4	caregivers	caregiver	NNS
cord-006702-ekf6mja9	736	5	appears	appear	VBZ
cord-006702-ekf6mja9	736	6	to	to	TO
cord-006702-ekf6mja9	736	7	have	have	VB
cord-006702-ekf6mja9	736	8	a	a	DT
cord-006702-ekf6mja9	736	9	profound	profound	JJ
cord-006702-ekf6mja9	736	10	impact	impact	NN
cord-006702-ekf6mja9	736	11	on	on	IN
cord-006702-ekf6mja9	736	12	the	the	DT
cord-006702-ekf6mja9	736	13	self	self	NN
cord-006702-ekf6mja9	736	14	-	-	HYPH
cord-006702-ekf6mja9	736	15	rated	rate	VBN
cord-006702-ekf6mja9	736	16	health	health	NN
cord-006702-ekf6mja9	736	17	in	in	IN
cord-006702-ekf6mja9	736	18	children	child	NNS
cord-006702-ekf6mja9	736	19	with	with	IN
cord-006702-ekf6mja9	736	20	CKD	CKD	NNP
cord-006702-ekf6mja9	736	21	.	.	.
cord-006702-ekf6mja9	737	1	Longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	737	2	follow	follow	NN
cord-006702-ekf6mja9	737	3	-	-	HYPH
cord-006702-ekf6mja9	737	4	up	up	NN
cord-006702-ekf6mja9	737	5	will	will	MD
cord-006702-ekf6mja9	737	6	help	help	VB
cord-006702-ekf6mja9	737	7	delineate	delineate	VB
cord-006702-ekf6mja9	737	8	the	the	DT
cord-006702-ekf6mja9	737	9	cause	cause	NN
cord-006702-ekf6mja9	737	10	of	of	IN
cord-006702-ekf6mja9	737	11	socioeconomic	socioeconomic	JJ
cord-006702-ekf6mja9	737	12	disadvantage	disadvantage	NN
cord-006702-ekf6mja9	737	13	in	in	IN
cord-006702-ekf6mja9	737	14	these	these	DT
cord-006702-ekf6mja9	737	15	children	child	NNS
cord-006702-ekf6mja9	737	16	and	and	CC
cord-006702-ekf6mja9	737	17	the	the	DT
cord-006702-ekf6mja9	737	18	long	long	JJ
cord-006702-ekf6mja9	737	19	-	-	HYPH
cord-006702-ekf6mja9	737	20	term	term	NN
cord-006702-ekf6mja9	737	21	effects	effect	NNS
cord-006702-ekf6mja9	737	22	on	on	IN
cord-006702-ekf6mja9	737	23	disease	disease	NN
cord-006702-ekf6mja9	737	24	progression	progression	NN
cord-006702-ekf6mja9	737	25	and	and	CC
cord-006702-ekf6mja9	737	26	wellbeing	wellbeing	NN
cord-006702-ekf6mja9	737	27	outcomes	outcome	NNS
cord-006702-ekf6mja9	737	28	.	.	.
cord-006702-ekf6mja9	738	1	FP	FP	NNP
cord-006702-ekf6mja9	738	2	-	-	HYPH
cord-006702-ekf6mja9	738	3	S22	S22	NNP
cord-006702-ekf6mja9	738	4	-	-	HYPH
cord-006702-ekf6mja9	738	5	1	1	CD
cord-006702-ekf6mja9	738	6	Renal	Renal	NNP
cord-006702-ekf6mja9	738	7	Gene	Gene	NNP
cord-006702-ekf6mja9	738	8	Panels	Panels	NNPS
cord-006702-ekf6mja9	738	9	promote	promote	VBP
cord-006702-ekf6mja9	738	10	rapid	rapid	JJ
cord-006702-ekf6mja9	738	11	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	738	12	in	in	IN
cord-006702-ekf6mja9	738	13	paediatric	paediatric	JJ
cord-006702-ekf6mja9	738	14	renal	renal	JJ
cord-006702-ekf6mja9	738	15	disease	disease	NN
cord-006702-ekf6mja9	738	16	of	of	IN
cord-006702-ekf6mja9	738	17	variable	variable	JJ
cord-006702-ekf6mja9	738	18	phenotype	phenotype	NN
cord-006702-ekf6mja9	738	19	H.	H.	NNP
cord-006702-ekf6mja9	738	20	Mccarthy	Mccarthy	NNP
cord-006702-ekf6mja9	738	21	(	(	-LRB-
cord-006702-ekf6mja9	738	22	1	1	CD
cord-006702-ekf6mja9	738	23	)	)	-RRB-
cord-006702-ekf6mja9	738	24	,	,	,
cord-006702-ekf6mja9	738	25	A.	A.	NNP
cord-006702-ekf6mja9	738	26	Mallett	Mallett	NNP
cord-006702-ekf6mja9	738	27	(	(	-LRB-
cord-006702-ekf6mja9	738	28	2	2	CD
cord-006702-ekf6mja9	738	29	)	)	-RRB-
cord-006702-ekf6mja9	738	30	,	,	,
cord-006702-ekf6mja9	738	31	A.	A.	NNP
cord-006702-ekf6mja9	738	32	Mallawaarachchi	Mallawaarachchi	NNP
cord-006702-ekf6mja9	738	33	(	(	-LRB-
cord-006702-ekf6mja9	738	34	1	1	CD
cord-006702-ekf6mja9	738	35	)	)	-RRB-
cord-006702-ekf6mja9	738	36	,	,	,
cord-006702-ekf6mja9	738	37	K.	K.	NNP
cord-006702-ekf6mja9	738	38	Holman	Holman	NNP
cord-006702-ekf6mja9	738	39	(	(	-LRB-
cord-006702-ekf6mja9	738	40	1	1	CD
cord-006702-ekf6mja9	738	41	)	)	-RRB-
cord-006702-ekf6mja9	738	42	,	,	,
cord-006702-ekf6mja9	738	43	G.	G.	NNP
cord-006702-ekf6mja9	738	44	Ho	Ho	NNP
cord-006702-ekf6mja9	738	45	(	(	-LRB-
cord-006702-ekf6mja9	738	46	1	1	CD
cord-006702-ekf6mja9	738	47	)	)	-RRB-
cord-006702-ekf6mja9	738	48	,	,	,
cord-006702-ekf6mja9	738	49	B.	B.	NNP
cord-006702-ekf6mja9	738	50	Bennetts	Bennetts	NNP
cord-006702-ekf6mja9	738	51	(	(	-LRB-
cord-006702-ekf6mja9	738	52	1	1	CD
cord-006702-ekf6mja9	738	53	)	)	-RRB-
cord-006702-ekf6mja9	738	54	,	,	,
cord-006702-ekf6mja9	738	55	S.	S.	NNP
cord-006702-ekf6mja9	738	56	Alexander	Alexander	NNP
cord-006702-ekf6mja9	738	57	(	(	-LRB-
cord-006702-ekf6mja9	738	58	1	1	CD
cord-006702-ekf6mja9	738	59	&	&	CC
cord-006702-ekf6mja9	738	60	Table	Table	NNP
cord-006702-ekf6mja9	738	61	1	1	CD
cord-006702-ekf6mja9	738	62	.	.	.
cord-006702-ekf6mja9	739	1	Results	result	NNS
cord-006702-ekf6mja9	739	2	per	per	IN
cord-006702-ekf6mja9	739	3	panel	panel	NN
cord-006702-ekf6mja9	739	4	In	in	IN
cord-006702-ekf6mja9	739	5	nearly	nearly	RB
cord-006702-ekf6mja9	739	6	50	50	CD
cord-006702-ekf6mja9	739	7	%	%	NN
cord-006702-ekf6mja9	739	8	of	of	IN
cord-006702-ekf6mja9	739	9	cases	case	NNS
cord-006702-ekf6mja9	739	10	referred	refer	VBN
cord-006702-ekf6mja9	739	11	for	for	IN
cord-006702-ekf6mja9	739	12	diagnostic	diagnostic	JJ
cord-006702-ekf6mja9	739	13	renal	renal	JJ
cord-006702-ekf6mja9	739	14	gene	gene	NN
cord-006702-ekf6mja9	739	15	panels	panel	NNS
cord-006702-ekf6mja9	739	16	,	,	,
cord-006702-ekf6mja9	739	17	a	a	DT
cord-006702-ekf6mja9	739	18	pathological	pathological	JJ
cord-006702-ekf6mja9	739	19	result	result	NN
cord-006702-ekf6mja9	739	20	was	be	VBD
cord-006702-ekf6mja9	739	21	found	find	VBN
cord-006702-ekf6mja9	739	22	to	to	TO
cord-006702-ekf6mja9	739	23	explain	explain	VB
cord-006702-ekf6mja9	739	24	the	the	DT
cord-006702-ekf6mja9	739	25	phenotype	phenotype	NN
cord-006702-ekf6mja9	739	26	.	.	.
cord-006702-ekf6mja9	740	1	Certain	certain	JJ
cord-006702-ekf6mja9	740	2	panels	panel	NNS
cord-006702-ekf6mja9	740	3	are	be	VBP
cord-006702-ekf6mja9	740	4	highly	highly	RB
cord-006702-ekf6mja9	740	5	likely	likely	JJ
cord-006702-ekf6mja9	740	6	to	to	TO
cord-006702-ekf6mja9	740	7	reveal	reveal	VB
cord-006702-ekf6mja9	740	8	a	a	DT
cord-006702-ekf6mja9	740	9	useful	useful	JJ
cord-006702-ekf6mja9	740	10	result	result	NN
cord-006702-ekf6mja9	740	11	e.g.	e.g.	IN
cord-006702-ekf6mja9	740	12	Alport	Alport	NNP
cord-006702-ekf6mja9	740	13	's	's	POS
cord-006702-ekf6mja9	740	14	panel	panel	NN
cord-006702-ekf6mja9	740	15	and	and	CC
cord-006702-ekf6mja9	740	16	the	the	DT
cord-006702-ekf6mja9	740	17	Tubular	Tubular	NNP
cord-006702-ekf6mja9	740	18	panel	panel	NN
cord-006702-ekf6mja9	740	19	,	,	,
cord-006702-ekf6mja9	740	20	whereas	whereas	IN
cord-006702-ekf6mja9	740	21	the	the	DT
cord-006702-ekf6mja9	740	22	panel	panel	NN
cord-006702-ekf6mja9	740	23	for	for	IN
cord-006702-ekf6mja9	740	24	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	740	25	remains	remain	VBZ
cord-006702-ekf6mja9	740	26	low	low	JJ
cord-006702-ekf6mja9	740	27	yield	yield	NN
cord-006702-ekf6mja9	740	28	reflecting	reflect	VBG
cord-006702-ekf6mja9	740	29	that	that	IN
cord-006702-ekf6mja9	740	30	previously	previously	RB
cord-006702-ekf6mja9	740	31	described	describe	VBN
cord-006702-ekf6mja9	740	32	.	.	.
cord-006702-ekf6mja9	741	1	Prior	prior	RB
cord-006702-ekf6mja9	741	2	to	to	IN
cord-006702-ekf6mja9	741	3	2014	2014	CD
cord-006702-ekf6mja9	741	4	,	,	,
cord-006702-ekf6mja9	741	5	testing	test	VBG
cord-006702-ekf6mja9	741	6	for	for	IN
cord-006702-ekf6mja9	741	7	renal	renal	JJ
cord-006702-ekf6mja9	741	8	genes	gene	NNS
cord-006702-ekf6mja9	741	9	within	within	IN
cord-006702-ekf6mja9	741	10	Australasia	Australasia	NNP
cord-006702-ekf6mja9	741	11	was	be	VBD
cord-006702-ekf6mja9	741	12	extremely	extremely	RB
cord-006702-ekf6mja9	741	13	limited	limited	JJ
cord-006702-ekf6mja9	741	14	.	.	.
cord-006702-ekf6mja9	742	1	The	the	DT
cord-006702-ekf6mja9	742	2	arrival	arrival	NN
cord-006702-ekf6mja9	742	3	of	of	IN
cord-006702-ekf6mja9	742	4	diagnostic	diagnostic	JJ
cord-006702-ekf6mja9	742	5	panels	panel	NNS
cord-006702-ekf6mja9	742	6	for	for	IN
cord-006702-ekf6mja9	742	7	a	a	DT
cord-006702-ekf6mja9	742	8	variety	variety	NN
cord-006702-ekf6mja9	742	9	of	of	IN
cord-006702-ekf6mja9	742	10	renal	renal	JJ
cord-006702-ekf6mja9	742	11	conditions	condition	NNS
cord-006702-ekf6mja9	742	12	provides	provide	VBZ
cord-006702-ekf6mja9	742	13	the	the	DT
cord-006702-ekf6mja9	742	14	referring	refer	VBG
cord-006702-ekf6mja9	742	15	clinician	clinician	NN
cord-006702-ekf6mja9	742	16	with	with	IN
cord-006702-ekf6mja9	742	17	an	an	DT
cord-006702-ekf6mja9	742	18	additional	additional	JJ
cord-006702-ekf6mja9	742	19	and	and	CC
cord-006702-ekf6mja9	742	20	important	important	JJ
cord-006702-ekf6mja9	742	21	tool	tool	NN
cord-006702-ekf6mja9	742	22	in	in	IN
cord-006702-ekf6mja9	742	23	the	the	DT
cord-006702-ekf6mja9	742	24	diagnostic	diagnostic	JJ
cord-006702-ekf6mja9	742	25	pathway	pathway	NN
cord-006702-ekf6mja9	742	26	to	to	TO
cord-006702-ekf6mja9	742	27	be	be	VB
cord-006702-ekf6mja9	742	28	used	use	VBN
cord-006702-ekf6mja9	742	29	in	in	IN
cord-006702-ekf6mja9	742	30	conjunction	conjunction	NN
cord-006702-ekf6mja9	742	31	with	with	IN
cord-006702-ekf6mja9	742	32	imaging	imaging	NN
cord-006702-ekf6mja9	742	33	,	,	,
cord-006702-ekf6mja9	742	34	serology	serology	NN
cord-006702-ekf6mja9	742	35	and	and	CC
cord-006702-ekf6mja9	742	36	histology	histology	NN
cord-006702-ekf6mja9	742	37	.	.	.
cord-006702-ekf6mja9	743	1	This	this	DT
cord-006702-ekf6mja9	743	2	model	model	NN
cord-006702-ekf6mja9	743	3	has	have	VBZ
cord-006702-ekf6mja9	743	4	demonstrated	demonstrate	VBN
cord-006702-ekf6mja9	743	5	the	the	DT
cord-006702-ekf6mja9	743	6	potential	potential	NN
cord-006702-ekf6mja9	743	7	of	of	IN
cord-006702-ekf6mja9	743	8	genetic	genetic	JJ
cord-006702-ekf6mja9	743	9	analysis	analysis	NN
cord-006702-ekf6mja9	743	10	in	in	IN
cord-006702-ekf6mja9	743	11	paediatric	paediatric	JJ
cord-006702-ekf6mja9	743	12	nephrology	nephrology	NN
cord-006702-ekf6mja9	743	13	and	and	CC
cord-006702-ekf6mja9	743	14	suggests	suggest	VBZ
cord-006702-ekf6mja9	743	15	it	-PRON-	PRP
cord-006702-ekf6mja9	743	16	will	will	MD
cord-006702-ekf6mja9	743	17	become	become	VB
cord-006702-ekf6mja9	743	18	mainstream	mainstream	JJ
cord-006702-ekf6mja9	743	19	practicein	practicein	NNP
cord-006702-ekf6mja9	743	20	the	the	DT
cord-006702-ekf6mja9	743	21	next	next	JJ
cord-006702-ekf6mja9	743	22	few	few	JJ
cord-006702-ekf6mja9	743	23	years	year	NNS
cord-006702-ekf6mja9	743	24	.	.	.
cord-006702-ekf6mja9	744	1	Objectives	objective	NNS
cord-006702-ekf6mja9	744	2	:	:	:
cord-006702-ekf6mja9	744	3	At	at	RB
cord-006702-ekf6mja9	744	4	least	least	RBS
cord-006702-ekf6mja9	744	5	10	10	CD
cord-006702-ekf6mja9	744	6	%	%	NN
cord-006702-ekf6mja9	744	7	of	of	IN
cord-006702-ekf6mja9	744	8	adults	adult	NNS
cord-006702-ekf6mja9	744	9	who	who	WP
cord-006702-ekf6mja9	744	10	receive	receive	VBP
cord-006702-ekf6mja9	744	11	renal	renal	JJ
cord-006702-ekf6mja9	744	12	-	-	HYPH
cord-006702-ekf6mja9	744	13	replacement	replacement	NN
cord-006702-ekf6mja9	744	14	therapy	therapy	NN
cord-006702-ekf6mja9	744	15	(	(	-LRB-
cord-006702-ekf6mja9	744	16	RRT	RRT	NNP
cord-006702-ekf6mja9	744	17	)	)	-RRB-
cord-006702-ekf6mja9	744	18	have	have	VBP
cord-006702-ekf6mja9	744	19	an	an	DT
cord-006702-ekf6mja9	744	20	inherited	inherit	VBN
cord-006702-ekf6mja9	744	21	kidney	kidney	NN
cord-006702-ekf6mja9	744	22	disease	disease	NN
cord-006702-ekf6mja9	744	23	.	.	.
cord-006702-ekf6mja9	745	1	We	-PRON-	PRP
cord-006702-ekf6mja9	745	2	sought	seek	VBD
cord-006702-ekf6mja9	745	3	to	to	TO
cord-006702-ekf6mja9	745	4	determine	determine	VB
cord-006702-ekf6mja9	745	5	the	the	DT
cord-006702-ekf6mja9	745	6	frequency	frequency	NN
cord-006702-ekf6mja9	745	7	of	of	IN
cord-006702-ekf6mja9	745	8	gene	gene	NN
cord-006702-ekf6mja9	745	9	mutations	mutation	NNS
cord-006702-ekf6mja9	745	10	in	in	IN
cord-006702-ekf6mja9	745	11	a	a	DT
cord-006702-ekf6mja9	745	12	heterogeneous	heterogeneous	JJ
cord-006702-ekf6mja9	745	13	population	population	NN
cord-006702-ekf6mja9	745	14	of	of	IN
cord-006702-ekf6mja9	745	15	children	child	NNS
cord-006702-ekf6mja9	745	16	with	with	IN
cord-006702-ekf6mja9	745	17	end	end	NN
cord-006702-ekf6mja9	745	18	-	-	HYPH
cord-006702-ekf6mja9	745	19	stage	stage	NN
cord-006702-ekf6mja9	745	20	renal	renal	JJ
cord-006702-ekf6mja9	745	21	disease	disease	NN
cord-006702-ekf6mja9	745	22	.	.	.
cord-006702-ekf6mja9	746	1	Methods	method	NNS
cord-006702-ekf6mja9	746	2	:	:	:
cord-006702-ekf6mja9	747	1	This	this	DT
cord-006702-ekf6mja9	747	2	study	study	NN
cord-006702-ekf6mja9	747	3	used	use	VBD
cord-006702-ekf6mja9	747	4	next	next	JJ
cord-006702-ekf6mja9	747	5	generation	generation	NN
cord-006702-ekf6mja9	747	6	sequencing	sequence	VBG
cord-006702-ekf6mja9	747	7	to	to	TO
cord-006702-ekf6mja9	747	8	screen	screen	VB
cord-006702-ekf6mja9	747	9	4000	4000	CD
cord-006702-ekf6mja9	747	10	genes	gene	NNS
cord-006702-ekf6mja9	747	11	,	,	,
cord-006702-ekf6mja9	747	12	including	include	VBG
cord-006702-ekf6mja9	747	13	the	the	DT
cord-006702-ekf6mja9	747	14	40	40	CD
cord-006702-ekf6mja9	747	15	genes	gene	NNS
cord-006702-ekf6mja9	747	16	known	know	VBN
cord-006702-ekf6mja9	747	17	to	to	TO
cord-006702-ekf6mja9	747	18	be	be	VB
cord-006702-ekf6mja9	747	19	associated	associate	VBN
cord-006702-ekf6mja9	747	20	with	with	IN
cord-006702-ekf6mja9	747	21	mitochondrial	mitochondrial	JJ
cord-006702-ekf6mja9	747	22	disease	disease	NN
cord-006702-ekf6mja9	747	23	.	.	.
cord-006702-ekf6mja9	748	1	The	the	DT
cord-006702-ekf6mja9	748	2	first	first	JJ
cord-006702-ekf6mja9	748	3	46	46	CD
cord-006702-ekf6mja9	748	4	pediatric	pediatric	JJ
cord-006702-ekf6mja9	748	5	patients	patient	NNS
cord-006702-ekf6mja9	748	6	collected	collect	VBN
cord-006702-ekf6mja9	748	7	from	from	IN
cord-006702-ekf6mja9	748	8	Department	Department	NNP
cord-006702-ekf6mja9	748	9	of	of	IN
cord-006702-ekf6mja9	748	10	Nephrology	Nephrology	NNP
cord-006702-ekf6mja9	748	11	and	and	CC
cord-006702-ekf6mja9	748	12	Rheumatology	Rheumatology	NNP
cord-006702-ekf6mja9	748	13	,	,	,
cord-006702-ekf6mja9	748	14	Children	Children	NNP
cord-006702-ekf6mja9	748	15	's	's	POS
cord-006702-ekf6mja9	748	16	Hospital	Hospital	NNP
cord-006702-ekf6mja9	748	17	of	of	IN
cord-006702-ekf6mja9	748	18	Fudan	Fudan	NNP
cord-006702-ekf6mja9	748	19	Universitywere	Universitywere	NNP
cord-006702-ekf6mja9	748	20	chosen	choose	VBN
cord-006702-ekf6mja9	748	21	with	with	IN
cord-006702-ekf6mja9	748	22	comprehensive	comprehensive	JJ
cord-006702-ekf6mja9	748	23	phenotypic	phenotypic	JJ
cord-006702-ekf6mja9	748	24	detail	detail	NN
cord-006702-ekf6mja9	748	25	.	.	.
cord-006702-ekf6mja9	749	1	Significant	significant	JJ
cord-006702-ekf6mja9	749	2	variants	variant	NNS
cord-006702-ekf6mja9	749	3	detected	detect	VBN
cord-006702-ekf6mja9	749	4	by	by	IN
cord-006702-ekf6mja9	749	5	next	next	JJ
cord-006702-ekf6mja9	749	6	generation	generation	NN
cord-006702-ekf6mja9	749	7	sequencing	sequencing	NN
cord-006702-ekf6mja9	749	8	were	be	VBD
cord-006702-ekf6mja9	749	9	confirmed	confirm	VBN
cord-006702-ekf6mja9	749	10	by	by	IN
cord-006702-ekf6mja9	749	11	conventional	conventional	JJ
cord-006702-ekf6mja9	749	12	Sanger	Sanger	NNP
cord-006702-ekf6mja9	749	13	sequencing	sequencing	NN
cord-006702-ekf6mja9	749	14	and	and	CC
cord-006702-ekf6mja9	749	15	segregation	segregation	NN
cord-006702-ekf6mja9	749	16	analysis	analysis	NN
cord-006702-ekf6mja9	749	17	was	be	VBD
cord-006702-ekf6mja9	749	18	performed	perform	VBN
cord-006702-ekf6mja9	749	19	using	use	VBG
cord-006702-ekf6mja9	749	20	parental	parental	JJ
cord-006702-ekf6mja9	749	21	DNA	dna	NN
cord-006702-ekf6mja9	749	22	samples	sample	NNS
cord-006702-ekf6mja9	749	23	.	.	.
cord-006702-ekf6mja9	750	1	Results	result	NNS
cord-006702-ekf6mja9	750	2	:	:	:
cord-006702-ekf6mja9	751	1	A	a	DT
cord-006702-ekf6mja9	751	2	total	total	NN
cord-006702-ekf6mja9	751	3	of	of	IN
cord-006702-ekf6mja9	751	4	46	46	CD
cord-006702-ekf6mja9	751	5	patients	patient	NNS
cord-006702-ekf6mja9	751	6	(	(	-LRB-
cord-006702-ekf6mja9	751	7	females	female	NNS
cord-006702-ekf6mja9	751	8	16	16	CD
cord-006702-ekf6mja9	751	9	,	,	,
cord-006702-ekf6mja9	751	10	males	male	NNS
cord-006702-ekf6mja9	751	11	30	30	CD
cord-006702-ekf6mja9	751	12	)	)	-RRB-
cord-006702-ekf6mja9	751	13	with	with	IN
cord-006702-ekf6mja9	751	14	RRT(PD	rrt(pd	CD
cord-006702-ekf6mja9	751	15	38	38	CD
cord-006702-ekf6mja9	751	16	,	,	,
cord-006702-ekf6mja9	751	17	HD	HD	NNP
cord-006702-ekf6mja9	751	18	3	3	CD
cord-006702-ekf6mja9	751	19	,	,	,
cord-006702-ekf6mja9	751	20	Tx	Tx	NNP
cord-006702-ekf6mja9	751	21	5	5	CD
cord-006702-ekf6mja9	751	22	)	)	-RRB-
cord-006702-ekf6mja9	751	23	were	be	VBD
cord-006702-ekf6mja9	751	24	identified	identify	VBN
cord-006702-ekf6mja9	751	25	,	,	,
cord-006702-ekf6mja9	751	26	with	with	IN
cord-006702-ekf6mja9	751	27	a	a	DT
cord-006702-ekf6mja9	751	28	mean	mean	JJ
cord-006702-ekf6mja9	751	29	age	age	NN
cord-006702-ekf6mja9	751	30	of	of	IN
cord-006702-ekf6mja9	751	31	7.2	7.2	CD
cord-006702-ekf6mja9	751	32	±	±	CD
cord-006702-ekf6mja9	751	33	6.4	6.4	CD
cord-006702-ekf6mja9	751	34	years	year	NNS
cord-006702-ekf6mja9	752	1	(	(	-LRB-
cord-006702-ekf6mja9	752	2	range	range	NN
cord-006702-ekf6mja9	752	3	from	from	IN
cord-006702-ekf6mja9	752	4	0.1	0.1	CD
cord-006702-ekf6mja9	752	5	to	to	IN
cord-006702-ekf6mja9	752	6	12.2	12.2	CD
cord-006702-ekf6mja9	752	7	years	year	NNS
cord-006702-ekf6mja9	752	8	)	)	-RRB-
cord-006702-ekf6mja9	752	9	.	.	.
cord-006702-ekf6mja9	753	1	Analysis	analysis	NN
cord-006702-ekf6mja9	753	2	revealed	reveal	VBD
cord-006702-ekf6mja9	753	3	known	know	VBN
cord-006702-ekf6mja9	753	4	and	and	CC
cord-006702-ekf6mja9	753	5	novel	novel	JJ
cord-006702-ekf6mja9	753	6	disease	disease	NN
cord-006702-ekf6mja9	753	7	-	-	HYPH
cord-006702-ekf6mja9	753	8	associated	associate	VBN
cord-006702-ekf6mja9	753	9	variations	variation	NNS
cord-006702-ekf6mja9	753	10	in	in	IN
cord-006702-ekf6mja9	753	11	genes	gene	NNS
cord-006702-ekf6mja9	753	12	(	(	-LRB-
cord-006702-ekf6mja9	753	13	NPHS1	nphs1	NN
cord-006702-ekf6mja9	753	14	,	,	,
cord-006702-ekf6mja9	753	15	NPHS2	NPHS2	NNP
cord-006702-ekf6mja9	753	16	,	,	,
cord-006702-ekf6mja9	753	17	PLCE1	plce1	NN
cord-006702-ekf6mja9	753	18	,	,	,
cord-006702-ekf6mja9	753	19	WT1	wt1	RB
cord-006702-ekf6mja9	753	20	,	,	,
cord-006702-ekf6mja9	753	21	SLC12A1	slc12a1	NN
cord-006702-ekf6mja9	753	22	,	,	,
cord-006702-ekf6mja9	753	23	TTC21B	ttc21b	NN
cord-006702-ekf6mja9	753	24	,	,	,
cord-006702-ekf6mja9	753	25	AGXT	AGXT	NNP
cord-006702-ekf6mja9	753	26	,	,	,
cord-006702-ekf6mja9	753	27	SCNN1	SCNN1	NNP
cord-006702-ekf6mja9	753	28	G	G	NNP
cord-006702-ekf6mja9	753	29	,	,	,
cord-006702-ekf6mja9	753	30	COQ2	COQ2	NNP
cord-006702-ekf6mja9	753	31	and	and	CC
cord-006702-ekf6mja9	753	32	ADCK4	ADCK4	NNP
cord-006702-ekf6mja9	753	33	)	)	-RRB-
cord-006702-ekf6mja9	753	34	associated	associate	VBN
cord-006702-ekf6mja9	753	35	with	with	IN
cord-006702-ekf6mja9	753	36	inherited	inherit	VBN
cord-006702-ekf6mja9	753	37	kidney	kidney	NN
cord-006702-ekf6mja9	753	38	diseasein	diseasein	NNP
cord-006702-ekf6mja9	753	39	56.5	56.5	CD
cord-006702-ekf6mja9	753	40	%	%	NN
cord-006702-ekf6mja9	753	41	(	(	-LRB-
cord-006702-ekf6mja9	753	42	26/46	26/46	CD
cord-006702-ekf6mja9	753	43	)	)	-RRB-
cord-006702-ekf6mja9	753	44	of	of	IN
cord-006702-ekf6mja9	753	45	patients	patient	NNS
cord-006702-ekf6mja9	753	46	.	.	.
cord-006702-ekf6mja9	754	1	Of	of	IN
cord-006702-ekf6mja9	754	2	these	these	DT
cord-006702-ekf6mja9	754	3	46	46	CD
cord-006702-ekf6mja9	754	4	patients	patient	NNS
cord-006702-ekf6mja9	754	5	,	,	,
cord-006702-ekf6mja9	754	6	15	15	CD
cord-006702-ekf6mja9	754	7	had	have	VBD
cord-006702-ekf6mja9	754	8	compound	compound	JJ
cord-006702-ekf6mja9	754	9	heterozygous	heterozygous	JJ
cord-006702-ekf6mja9	754	10	mutations	mutation	NNS
cord-006702-ekf6mja9	754	11	,	,	,
cord-006702-ekf6mja9	754	12	6	6	CD
cord-006702-ekf6mja9	754	13	had	have	VBD
cord-006702-ekf6mja9	754	14	heterozygous	heterozygous	JJ
cord-006702-ekf6mja9	754	15	mutations	mutation	NNS
cord-006702-ekf6mja9	754	16	(	(	-LRB-
cord-006702-ekf6mja9	754	17	de	de	FW
cord-006702-ekf6mja9	754	18	novo	novo	NNP
cord-006702-ekf6mja9	754	19	mutation	mutation	NN
cord-006702-ekf6mja9	754	20	)	)	-RRB-
cord-006702-ekf6mja9	754	21	,	,	,
cord-006702-ekf6mja9	754	22	5	5	CD
cord-006702-ekf6mja9	754	23	had	have	VBD
cord-006702-ekf6mja9	754	24	homozygous	homozygous	JJ
cord-006702-ekf6mja9	754	25	mutations	mutation	NNS
cord-006702-ekf6mja9	754	26	.	.	.
cord-006702-ekf6mja9	755	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	755	2	:	:	:
cord-006702-ekf6mja9	756	1	More	More	JJR
cord-006702-ekf6mja9	756	2	than	than	IN
cord-006702-ekf6mja9	756	3	half	half	JJ
cord-006702-ekf6mja9	756	4	children	child	NNS
cord-006702-ekf6mja9	756	5	who	who	WP
cord-006702-ekf6mja9	756	6	receive	receive	VBP
cord-006702-ekf6mja9	756	7	renal	renal	JJ
cord-006702-ekf6mja9	756	8	-	-	HYPH
cord-006702-ekf6mja9	756	9	replacement	replacement	NN
cord-006702-ekf6mja9	756	10	therapy	therapy	NN
cord-006702-ekf6mja9	756	11	haveknown	haveknown	NN
cord-006702-ekf6mja9	756	12	and	and	CC
cord-006702-ekf6mja9	756	13	novel	novel	JJ
cord-006702-ekf6mja9	756	14	disease	disease	NN
cord-006702-ekf6mja9	756	15	-	-	HYPH
cord-006702-ekf6mja9	756	16	associated	associate	VBN
cord-006702-ekf6mja9	756	17	variations	variation	NNS
cord-006702-ekf6mja9	756	18	in	in	IN
cord-006702-ekf6mja9	756	19	genes	gene	NNS
cord-006702-ekf6mja9	756	20	associated	associate	VBD
cord-006702-ekf6mja9	756	21	withinherited	withinherited	JJ
cord-006702-ekf6mja9	756	22	kidney	kidney	NN
cord-006702-ekf6mja9	756	23	disease	disease	NN
cord-006702-ekf6mja9	756	24	.	.	.
cord-006702-ekf6mja9	757	1	This	this	DT
cord-006702-ekf6mja9	757	2	study	study	NN
cord-006702-ekf6mja9	757	3	shows	show	VBZ
cord-006702-ekf6mja9	757	4	that	that	IN
cord-006702-ekf6mja9	757	5	next	next	JJ
cord-006702-ekf6mja9	757	6	generation	generation	NN
cord-006702-ekf6mja9	757	7	sequencing	sequencing	NN
cord-006702-ekf6mja9	757	8	analysis	analysis	NN
cord-006702-ekf6mja9	757	9	of	of	IN
cord-006702-ekf6mja9	757	10	pediatric	pediatric	JJ
cord-006702-ekf6mja9	757	11	end	end	NN
cord-006702-ekf6mja9	757	12	-	-	HYPH
cord-006702-ekf6mja9	757	13	stage	stage	NN
cord-006702-ekf6mja9	757	14	renal	renal	JJ
cord-006702-ekf6mja9	757	15	disease	disease	NN
cord-006702-ekf6mja9	757	16	patients	patient	NNS
cord-006702-ekf6mja9	757	17	is	be	VBZ
cord-006702-ekf6mja9	757	18	accurate	accurate	JJ
cord-006702-ekf6mja9	757	19	and	and	CC
cord-006702-ekf6mja9	757	20	revealing	revealing	JJ
cord-006702-ekf6mja9	757	21	.	.	.
cord-006702-ekf6mja9	758	1	This	this	DT
cord-006702-ekf6mja9	758	2	analysis	analysis	NN
cord-006702-ekf6mja9	758	3	should	should	MD
cord-006702-ekf6mja9	758	4	be	be	VB
cord-006702-ekf6mja9	758	5	considered	consider	VBN
cord-006702-ekf6mja9	758	6	part	part	NN
cord-006702-ekf6mja9	758	7	of	of	IN
cord-006702-ekf6mja9	758	8	the	the	DT
cord-006702-ekf6mja9	758	9	routine	routine	JJ
cord-006702-ekf6mja9	758	10	genetic	genetic	JJ
cord-006702-ekf6mja9	758	11	workup	workup	NN
cord-006702-ekf6mja9	758	12	of	of	IN
cord-006702-ekf6mja9	758	13	end	end	NN
cord-006702-ekf6mja9	758	14	-	-	HYPH
cord-006702-ekf6mja9	758	15	stage	stage	NN
cord-006702-ekf6mja9	758	16	renal	renal	JJ
cord-006702-ekf6mja9	758	17	disease	disease	NN
cord-006702-ekf6mja9	758	18	,	,	,
cord-006702-ekf6mja9	758	19	where	where	WRB
cord-006702-ekf6mja9	758	20	the	the	DT
cord-006702-ekf6mja9	758	21	proportion	proportion	NN
cord-006702-ekf6mja9	758	22	of	of	IN
cord-006702-ekf6mja9	758	23	genetic	genetic	JJ
cord-006702-ekf6mja9	758	24	mutation	mutation	NN
cord-006702-ekf6mja9	758	25	is	be	VBZ
cord-006702-ekf6mja9	758	26	high	high	JJ
cord-006702-ekf6mja9	758	27	but	but	CC
cord-006702-ekf6mja9	758	28	requires	require	VBZ
cord-006702-ekf6mja9	758	29	sequencing	sequencing	NN
cord-006702-ekf6mja9	758	30	of	of	IN
cord-006702-ekf6mja9	758	31	multiple	multiple	JJ
cord-006702-ekf6mja9	758	32	genes	gene	NNS
cord-006702-ekf6mja9	758	33	.	.	.
cord-006702-ekf6mja9	759	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	759	2	:	:	:
cord-006702-ekf6mja9	760	1	Urinary	urinary	JJ
cord-006702-ekf6mja9	760	2	metabolomic	metabolomic	NN
cord-006702-ekf6mja9	760	3	profiling	profiling	NN
cord-006702-ekf6mja9	760	4	is	be	VBZ
cord-006702-ekf6mja9	760	5	a	a	DT
cord-006702-ekf6mja9	760	6	feasible	feasible	JJ
cord-006702-ekf6mja9	760	7	technology	technology	NN
cord-006702-ekf6mja9	760	8	to	to	TO
cord-006702-ekf6mja9	760	9	help	help	VB
cord-006702-ekf6mja9	760	10	identify	identify	VB
cord-006702-ekf6mja9	760	11	metabolites	metabolite	NNS
cord-006702-ekf6mja9	760	12	that	that	WDT
cord-006702-ekf6mja9	760	13	can	can	MD
cord-006702-ekf6mja9	760	14	distinguish	distinguish	VB
cord-006702-ekf6mja9	760	15	SRNS	SRNS	NNP
cord-006702-ekf6mja9	760	16	from	from	IN
cord-006702-ekf6mja9	760	17	SSNS	SSNS	NNP
cord-006702-ekf6mja9	760	18	.	.	.
cord-006702-ekf6mja9	761	1	Can	Can	MD
cord-006702-ekf6mja9	761	2	urinary	urinary	JJ
cord-006702-ekf6mja9	761	3	proteomes	proteome	NNS
cord-006702-ekf6mja9	761	4	be	be	VB
cord-006702-ekf6mja9	761	5	used	use	VBN
cord-006702-ekf6mja9	761	6	as	as	IN
cord-006702-ekf6mja9	761	7	non	non	JJ
cord-006702-ekf6mja9	761	8	-	-	JJ
cord-006702-ekf6mja9	761	9	invasive	invasive	JJ
cord-006702-ekf6mja9	761	10	markers	marker	NNS
cord-006702-ekf6mja9	761	11	for	for	IN
cord-006702-ekf6mja9	761	12	renal	renal	JJ
cord-006702-ekf6mja9	761	13	involvement	involvement	NN
cord-006702-ekf6mja9	761	14	in	in	IN
cord-006702-ekf6mja9	761	15	childhood	childhood	NN
cord-006702-ekf6mja9	761	16	febrile	febrile	JJ
cord-006702-ekf6mja9	761	17	Urinary	urinary	JJ
cord-006702-ekf6mja9	761	18	Tract	tract	NN
cord-006702-ekf6mja9	761	19	Infection	infection	NN
cord-006702-ekf6mja9	761	20	(	(	-LRB-
cord-006702-ekf6mja9	761	21	UTI	UTI	NNP
cord-006702-ekf6mja9	761	22	)	)	-RRB-
cord-006702-ekf6mja9	761	23	?	?	.
cord-006702-ekf6mja9	762	1	S.M.	S.M.	NNP
cord-006702-ekf6mja9	762	2	Chao	Chao	NNP
cord-006702-ekf6mja9	762	3	(	(	-LRB-
cord-006702-ekf6mja9	762	4	1	1	CD
cord-006702-ekf6mja9	762	5	)	)	-RRB-
cord-006702-ekf6mja9	762	6	,	,	,
cord-006702-ekf6mja9	762	7	J.	J.	NNP
cord-006702-ekf6mja9	762	8	Connolly	Connolly	NNP
cord-006702-ekf6mja9	762	9	(	(	-LRB-
cord-006702-ekf6mja9	762	10	2	2	CD
cord-006702-ekf6mja9	762	11	)	)	-RRB-
cord-006702-ekf6mja9	762	12	,	,	.
cord-006702-ekf6mja9	763	1	Y.H.	Y.H.	NNP
cord-006702-ekf6mja9	763	2	Ng	Ng	NNP
cord-006702-ekf6mja9	763	3	(	(	-LRB-
cord-006702-ekf6mja9	763	4	1	1	CD
cord-006702-ekf6mja9	763	5	)	)	-RRB-
cord-006702-ekf6mja9	763	6	,	,	,
cord-006702-ekf6mja9	763	7	I.	I.	NNP
cord-006702-ekf6mja9	763	8	Ganesan	Ganesan	NNP
cord-006702-ekf6mja9	763	9	(	(	-LRB-
cord-006702-ekf6mja9	763	10	1	1	CD
cord-006702-ekf6mja9	763	11	)	)	-RRB-
cord-006702-ekf6mja9	763	12	,	,	,
cord-006702-ekf6mja9	763	13	L.	L.	NNP
cord-006702-ekf6mja9	763	14	Bernett	Bernett	NNP
cord-006702-ekf6mja9	763	15	(	(	-LRB-
cord-006702-ekf6mja9	763	16	2	2	CD
cord-006702-ekf6mja9	763	17	)	)	-RRB-
cord-006702-ekf6mja9	763	18	(	(	-LRB-
cord-006702-ekf6mja9	763	19	1	1	LS
cord-006702-ekf6mja9	763	20	)	)	-RRB-
cord-006702-ekf6mja9	763	21	KK	KK	NNP
cord-006702-ekf6mja9	763	22	Women	Women	NNP
cord-006702-ekf6mja9	763	23	's	's	POS
cord-006702-ekf6mja9	763	24	and	and	CC
cord-006702-ekf6mja9	763	25	Children	Children	NNP
cord-006702-ekf6mja9	763	26	's	's	POS
cord-006702-ekf6mja9	763	27	Hospital	Hospital	NNP
cord-006702-ekf6mja9	763	28	,	,	,
cord-006702-ekf6mja9	763	29	Singapore	Singapore	NNP
cord-006702-ekf6mja9	763	30	,	,	,
cord-006702-ekf6mja9	763	31	Singapore	Singapore	NNP
cord-006702-ekf6mja9	763	32	;	;	:
cord-006702-ekf6mja9	763	33	(	(	-LRB-
cord-006702-ekf6mja9	763	34	2	2	LS
cord-006702-ekf6mja9	763	35	)	)	-RRB-
cord-006702-ekf6mja9	763	36	Institute	Institute	NNP
cord-006702-ekf6mja9	763	37	of	of	IN
cord-006702-ekf6mja9	763	38	Molecular	Molecular	NNP
cord-006702-ekf6mja9	763	39	and	and	CC
cord-006702-ekf6mja9	763	40	Cell	Cell	NNP
cord-006702-ekf6mja9	763	41	Biology	Biology	NNP
cord-006702-ekf6mja9	763	42	,	,	,
cord-006702-ekf6mja9	763	43	Singapore	Singapore	NNP
cord-006702-ekf6mja9	763	44	Agency	Agency	NNP
cord-006702-ekf6mja9	763	45	of	of	IN
cord-006702-ekf6mja9	763	46	Science	Science	NNP
cord-006702-ekf6mja9	763	47	and	and	CC
cord-006702-ekf6mja9	763	48	Technology	Technology	NNP
cord-006702-ekf6mja9	763	49	,	,	,
cord-006702-ekf6mja9	763	50	Singapore	Singapore	NNP
cord-006702-ekf6mja9	763	51	,	,	,
cord-006702-ekf6mja9	764	1	Singapore	Singapore	NNP
cord-006702-ekf6mja9	764	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	765	1	:	:	:
cord-006702-ekf6mja9	765	2	We	-PRON-	PRP
cord-006702-ekf6mja9	765	3	hypothesized	hypothesize	VBD
cord-006702-ekf6mja9	765	4	that	that	IN
cord-006702-ekf6mja9	765	5	proteomes	proteome	NNS
cord-006702-ekf6mja9	765	6	expressed	express	VBN
cord-006702-ekf6mja9	765	7	as	as	IN
cord-006702-ekf6mja9	765	8	downstream	downstream	JJ
cord-006702-ekf6mja9	765	9	effectors	effector	NNS
cord-006702-ekf6mja9	765	10	of	of	IN
cord-006702-ekf6mja9	765	11	UTI	UTI	NNP
cord-006702-ekf6mja9	765	12	that	that	WDT
cord-006702-ekf6mja9	765	13	are	be	VBP
cord-006702-ekf6mja9	765	14	easily	easily	RB
cord-006702-ekf6mja9	765	15	obtained	obtain	VBN
cord-006702-ekf6mja9	765	16	from	from	IN
cord-006702-ekf6mja9	765	17	urine	urine	NN
cord-006702-ekf6mja9	765	18	,	,	,
cord-006702-ekf6mja9	765	19	can	can	MD
cord-006702-ekf6mja9	765	20	serve	serve	VB
cord-006702-ekf6mja9	765	21	as	as	IN
cord-006702-ekf6mja9	765	22	early	early	JJ
cord-006702-ekf6mja9	765	23	markers	marker	NNS
cord-006702-ekf6mja9	765	24	of	of	IN
cord-006702-ekf6mja9	765	25	acute	acute	JJ
cord-006702-ekf6mja9	765	26	pyelonephritis	pyelonephritis	NN
cord-006702-ekf6mja9	765	27	(	(	-LRB-
cord-006702-ekf6mja9	765	28	APN	APN	NNP
cord-006702-ekf6mja9	765	29	)	)	-RRB-
cord-006702-ekf6mja9	765	30	and	and	CC
cord-006702-ekf6mja9	765	31	predictors	predictor	NNS
cord-006702-ekf6mja9	765	32	of	of	IN
cord-006702-ekf6mja9	765	33	renal	renal	JJ
cord-006702-ekf6mja9	765	34	scarring	scarring	NN
cord-006702-ekf6mja9	765	35	(	(	-LRB-
cord-006702-ekf6mja9	765	36	RS	rs	NN
cord-006702-ekf6mja9	765	37	)	)	-RRB-
cord-006702-ekf6mja9	765	38	.	.	.
cord-006702-ekf6mja9	766	1	Leveraging	leverage	VBG
cord-006702-ekf6mja9	766	2	on	on	IN
cord-006702-ekf6mja9	766	3	advances	advance	NNS
cord-006702-ekf6mja9	766	4	in	in	IN
cord-006702-ekf6mja9	766	5	high	high	JJ
cord-006702-ekf6mja9	766	6	throughput	throughput	NN
cord-006702-ekf6mja9	766	7	technologies	technology	NNS
cord-006702-ekf6mja9	766	8	and	and	CC
cord-006702-ekf6mja9	766	9	bioinformatics	bioinformatic	NNS
cord-006702-ekf6mja9	766	10	,	,	,
cord-006702-ekf6mja9	766	11	we	-PRON-	PRP
cord-006702-ekf6mja9	766	12	attempt	attempt	VBP
cord-006702-ekf6mja9	766	13	to	to	TO
cord-006702-ekf6mja9	766	14	examine	examine	VB
cord-006702-ekf6mja9	766	15	an	an	DT
cord-006702-ekf6mja9	766	16	extended	extended	JJ
cord-006702-ekf6mja9	766	17	range	range	NN
cord-006702-ekf6mja9	766	18	of	of	IN
cord-006702-ekf6mja9	766	19	urinary	urinary	JJ
cord-006702-ekf6mja9	766	20	proteomes	proteome	NNS
cord-006702-ekf6mja9	766	21	that	that	WDT
cord-006702-ekf6mja9	766	22	may	may	MD
cord-006702-ekf6mja9	766	23	be	be	VB
cord-006702-ekf6mja9	766	24	implicated	implicate	VBN
cord-006702-ekf6mja9	766	25	.	.	.
cord-006702-ekf6mja9	767	1	Methods	method	NNS
cord-006702-ekf6mja9	767	2	:	:	:
cord-006702-ekf6mja9	767	3	In	in	IN
cord-006702-ekf6mja9	767	4	this	this	DT
cord-006702-ekf6mja9	767	5	prospective	prospective	JJ
cord-006702-ekf6mja9	767	6	cohort	cohort	NN
cord-006702-ekf6mja9	767	7	analytical	analytical	JJ
cord-006702-ekf6mja9	767	8	study	study	NN
cord-006702-ekf6mja9	767	9	,	,	,
cord-006702-ekf6mja9	767	10	patients	patient	NNS
cord-006702-ekf6mja9	767	11	aged	aged	JJ
cord-006702-ekf6mja9	767	12	1	1	CD
cord-006702-ekf6mja9	767	13	month	month	NN
cord-006702-ekf6mja9	767	14	or	or	CC
cord-006702-ekf6mja9	767	15	more	more	JJR
cord-006702-ekf6mja9	767	16	with	with	IN
cord-006702-ekf6mja9	767	17	a	a	DT
cord-006702-ekf6mja9	767	18	clinical	clinical	JJ
cord-006702-ekf6mja9	767	19	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	767	20	of	of	IN
cord-006702-ekf6mja9	767	21	1st	1st	JJ
cord-006702-ekf6mja9	767	22	febrile	febrile	JJ
cord-006702-ekf6mja9	767	23	UTI	UTI	NNP
cord-006702-ekf6mja9	767	24	were	be	VBD
cord-006702-ekf6mja9	767	25	recruited	recruit	VBN
cord-006702-ekf6mja9	767	26	.	.	.
cord-006702-ekf6mja9	768	1	APN	APN	NNP
cord-006702-ekf6mja9	768	2	and	and	CC
cord-006702-ekf6mja9	768	3	RS	RS	NNP
cord-006702-ekf6mja9	768	4	were	be	VBD
cord-006702-ekf6mja9	768	5	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	768	6	by	by	IN
cord-006702-ekf6mja9	768	7	DMSA	DMSA	NNP
cord-006702-ekf6mja9	768	8	scans	scan	NNS
cord-006702-ekf6mja9	768	9	done	do	VBN
cord-006702-ekf6mja9	768	10	within	within	IN
cord-006702-ekf6mja9	768	11	5	5	CD
cord-006702-ekf6mja9	768	12	days	day	NNS
cord-006702-ekf6mja9	768	13	of	of	IN
cord-006702-ekf6mja9	768	14	UTI	UTI	NNP
cord-006702-ekf6mja9	768	15	and	and	CC
cord-006702-ekf6mja9	768	16	at	at	IN
cord-006702-ekf6mja9	768	17	6	6	CD
cord-006702-ekf6mja9	768	18	months	month	NNS
cord-006702-ekf6mja9	768	19	respectively	respectively	RB
cord-006702-ekf6mja9	768	20	.	.	.
cord-006702-ekf6mja9	769	1	Urine	urine	NN
cord-006702-ekf6mja9	769	2	for	for	IN
cord-006702-ekf6mja9	769	3	proteomic	proteomic	JJ
cord-006702-ekf6mja9	769	4	study	study	NN
cord-006702-ekf6mja9	769	5	were	be	VBD
cord-006702-ekf6mja9	769	6	collected	collect	VBN
cord-006702-ekf6mja9	769	7	at	at	IN
cord-006702-ekf6mja9	769	8	recruitment	recruitment	NN
cord-006702-ekf6mja9	769	9	.	.	.
cord-006702-ekf6mja9	770	1	US	US	NNP
cord-006702-ekf6mja9	770	2	and	and	CC
cord-006702-ekf6mja9	770	3	MCU	MCU	NNP
cord-006702-ekf6mja9	770	4	were	be	VBD
cord-006702-ekf6mja9	770	5	done	do	VBN
cord-006702-ekf6mja9	770	6	.	.	.
cord-006702-ekf6mja9	771	1	Using	use	VBG
cord-006702-ekf6mja9	771	2	multiplexing	multiplexe	VBG
cord-006702-ekf6mja9	771	3	bioassay	bioassay	NN
cord-006702-ekf6mja9	771	4	,	,	,
cord-006702-ekf6mja9	771	5	57	57	CD
cord-006702-ekf6mja9	771	6	cytokines	cytokine	NNS
cord-006702-ekf6mja9	771	7	,	,	,
cord-006702-ekf6mja9	771	8	14	14	CD
cord-006702-ekf6mja9	771	9	soluble	soluble	JJ
cord-006702-ekf6mja9	771	10	receptors	receptor	NNS
cord-006702-ekf6mja9	771	11	and	and	CC
cord-006702-ekf6mja9	771	12	8	8	CD
cord-006702-ekf6mja9	771	13	kidney	kidney	NN
cord-006702-ekf6mja9	771	14	markers	marker	NNS
cord-006702-ekf6mja9	771	15	were	be	VBD
cord-006702-ekf6mja9	771	16	measured	measure	VBN
cord-006702-ekf6mja9	771	17	and	and	CC
cord-006702-ekf6mja9	771	18	data	datum	NNS
cord-006702-ekf6mja9	771	19	analysed	analyse	VBD
cord-006702-ekf6mja9	771	20	using	use	VBG
cord-006702-ekf6mja9	771	21	bioinformatics	bioinformatics	NN
cord-006702-ekf6mja9	771	22	software	software	NN
cord-006702-ekf6mja9	771	23	.	.	.
cord-006702-ekf6mja9	772	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	772	2	:	:	:
cord-006702-ekf6mja9	773	1	This	this	DT
cord-006702-ekf6mja9	773	2	prospective	prospective	JJ
cord-006702-ekf6mja9	773	3	study	study	NN
cord-006702-ekf6mja9	773	4	of	of	IN
cord-006702-ekf6mja9	773	5	an	an	DT
cord-006702-ekf6mja9	773	6	extended	extended	JJ
cord-006702-ekf6mja9	773	7	repertoire	repertoire	NN
cord-006702-ekf6mja9	773	8	of	of	IN
cord-006702-ekf6mja9	773	9	urinary	urinary	JJ
cord-006702-ekf6mja9	773	10	proteomes	proteome	NNS
cord-006702-ekf6mja9	773	11	during	during	IN
cord-006702-ekf6mja9	773	12	UTI	UTI	NNP
cord-006702-ekf6mja9	773	13	showed	show	VBD
cord-006702-ekf6mja9	773	14	promising	promising	JJ
cord-006702-ekf6mja9	773	15	results	result	NNS
cord-006702-ekf6mja9	773	16	esp.in	esp.in	NNS
cord-006702-ekf6mja9	773	17	the	the	DT
cord-006702-ekf6mja9	773	18	prediction	prediction	NN
cord-006702-ekf6mja9	773	19	of	of	IN
cord-006702-ekf6mja9	773	20	RS	rs	NN
cord-006702-ekf6mja9	773	21	which	which	WDT
cord-006702-ekf6mja9	773	22	can	can	MD
cord-006702-ekf6mja9	773	23	potentially	potentially	RB
cord-006702-ekf6mja9	773	24	be	be	VB
cord-006702-ekf6mja9	773	25	translated	translate	VBN
cord-006702-ekf6mja9	773	26	to	to	IN
cord-006702-ekf6mja9	773	27	clinical	clinical	JJ
cord-006702-ekf6mja9	773	28	application	application	NN
cord-006702-ekf6mja9	773	29	of	of	IN
cord-006702-ekf6mja9	773	30	using	use	VBG
cord-006702-ekf6mja9	773	31	urinary	urinary	JJ
cord-006702-ekf6mja9	773	32	proteomes	proteome	NNS
cord-006702-ekf6mja9	773	33	as	as	IN
cord-006702-ekf6mja9	773	34	early	early	JJ
cord-006702-ekf6mja9	773	35	non	non	JJ
cord-006702-ekf6mja9	773	36	-	-	JJ
cord-006702-ekf6mja9	773	37	invasive	invasive	JJ
cord-006702-ekf6mja9	773	38	markers	marker	NNS
cord-006702-ekf6mja9	773	39	and	and	CC
cord-006702-ekf6mja9	773	40	predictors	predictor	NNS
cord-006702-ekf6mja9	773	41	of	of	IN
cord-006702-ekf6mja9	773	42	renal	renal	JJ
cord-006702-ekf6mja9	773	43	cortical	cortical	JJ
cord-006702-ekf6mja9	773	44	involvement	involvement	NN
cord-006702-ekf6mja9	773	45	.	.	.
cord-006702-ekf6mja9	774	1	Larger	large	JJR
cord-006702-ekf6mja9	774	2	cohort	cohort	NN
cord-006702-ekf6mja9	774	3	studies	study	NNS
cord-006702-ekf6mja9	774	4	are	be	VBP
cord-006702-ekf6mja9	774	5	needed	need	VBN
cord-006702-ekf6mja9	774	6	to	to	TO
cord-006702-ekf6mja9	774	7	test	test	VB
cord-006702-ekf6mja9	774	8	the	the	DT
cord-006702-ekf6mja9	774	9	validity	validity	NN
cord-006702-ekf6mja9	774	10	and	and	CC
cord-006702-ekf6mja9	774	11	reproducibility	reproducibility	NN
cord-006702-ekf6mja9	774	12	of	of	IN
cord-006702-ekf6mja9	774	13	these	these	DT
cord-006702-ekf6mja9	774	14	biomarkers	biomarker	NNS
cord-006702-ekf6mja9	774	15	.	.	.
cord-006702-ekf6mja9	775	1	FP	FP	NNP
cord-006702-ekf6mja9	775	2	-	-	HYPH
cord-006702-ekf6mja9	775	3	S23	S23	NNP
cord-006702-ekf6mja9	775	4	-	-	HYPH
cord-006702-ekf6mja9	775	5	1	1	CD
cord-006702-ekf6mja9	775	6	Immunogenicity	Immunogenicity	NNP
cord-006702-ekf6mja9	775	7	of	of	IN
cord-006702-ekf6mja9	775	8	Human	Human	NNP
cord-006702-ekf6mja9	775	9	Papillomavirus	Papillomavirus	NNP
cord-006702-ekf6mja9	775	10	Recombinant	Recombinant	NNP
cord-006702-ekf6mja9	775	11	Vaccine	Vaccine	NNP
cord-006702-ekf6mja9	775	12	in	in	IN
cord-006702-ekf6mja9	775	13	Children	Children	NNP
cord-006702-ekf6mja9	775	14	with	with	IN
cord-006702-ekf6mja9	775	15	CKD	CKD	NNP
cord-006702-ekf6mja9	775	16	D.	D.	NNP
cord-006702-ekf6mja9	775	17	Nelson	Nelson	NNP
cord-006702-ekf6mja9	775	18	(	(	-LRB-
cord-006702-ekf6mja9	775	19	1	1	CD
cord-006702-ekf6mja9	775	20	)	)	-RRB-
cord-006702-ekf6mja9	775	21	,	,	,
cord-006702-ekf6mja9	775	22	A.	A.	NNP
cord-006702-ekf6mja9	775	23	Neu	Neu	NNP
cord-006702-ekf6mja9	775	24	(	(	-LRB-
cord-006702-ekf6mja9	775	25	1	1	CD
cord-006702-ekf6mja9	775	26	)	)	-RRB-
cord-006702-ekf6mja9	775	27	,	,	,
cord-006702-ekf6mja9	775	28	A.	A.	NNP
cord-006702-ekf6mja9	775	29	Abraham	Abraham	NNP
cord-006702-ekf6mja9	775	30	(	(	-LRB-
cord-006702-ekf6mja9	775	31	2	2	CD
cord-006702-ekf6mja9	775	32	)	)	-RRB-
cord-006702-ekf6mja9	775	33	,	,	,
cord-006702-ekf6mja9	775	34	S.	S.	NNP
cord-006702-ekf6mja9	775	35	Amaral	Amaral	NNP
cord-006702-ekf6mja9	775	36	(	(	-LRB-
cord-006702-ekf6mja9	775	37	3	3	CD
cord-006702-ekf6mja9	775	38	)	)	-RRB-
cord-006702-ekf6mja9	775	39	,	,	,
cord-006702-ekf6mja9	775	40	D.	D.	NNP
cord-006702-ekf6mja9	775	41	Batisky	Batisky	NNP
cord-006702-ekf6mja9	775	42	(	(	-LRB-
cord-006702-ekf6mja9	775	43	4	4	CD
cord-006702-ekf6mja9	775	44	)	)	-RRB-
cord-006702-ekf6mja9	775	45	,	,	,
cord-006702-ekf6mja9	775	46	J.	J.	NNP
cord-006702-ekf6mja9	775	47	Fadrowski	Fadrowski	NNP
cord-006702-ekf6mja9	775	48	(	(	-LRB-
cord-006702-ekf6mja9	775	49	1	1	CD
cord-006702-ekf6mja9	775	50	)	)	-RRB-
cord-006702-ekf6mja9	775	51	(	(	-LRB-
cord-006702-ekf6mja9	775	52	1	1	LS
cord-006702-ekf6mja9	775	53	)	)	-RRB-
cord-006702-ekf6mja9	775	54	Johns	Johns	NNP
cord-006702-ekf6mja9	775	55	Hopkins	Hopkins	NNP
cord-006702-ekf6mja9	775	56	University	University	NNP
cord-006702-ekf6mja9	775	57	School	School	NNP
cord-006702-ekf6mja9	775	58	of	of	IN
cord-006702-ekf6mja9	775	59	Medicine	Medicine	NNP
cord-006702-ekf6mja9	775	60	,	,	,
cord-006702-ekf6mja9	775	61	Baltimore	Baltimore	NNP
cord-006702-ekf6mja9	775	62	,	,	,
cord-006702-ekf6mja9	775	63	United	United	NNP
cord-006702-ekf6mja9	775	64	States	States	NNP
cord-006702-ekf6mja9	775	65	;	;	:
cord-006702-ekf6mja9	775	66	(	(	-LRB-
cord-006702-ekf6mja9	775	67	2	2	LS
cord-006702-ekf6mja9	775	68	)	)	-RRB-
cord-006702-ekf6mja9	775	69	Johns	Johns	NNP
cord-006702-ekf6mja9	775	70	Hopkins	Hopkins	NNP
cord-006702-ekf6mja9	775	71	University	University	NNP
cord-006702-ekf6mja9	775	72	Bloomberg	Bloomberg	NNP
cord-006702-ekf6mja9	775	73	School	School	NNP
cord-006702-ekf6mja9	775	74	of	of	IN
cord-006702-ekf6mja9	775	75	Public	Public	NNP
cord-006702-ekf6mja9	775	76	Health	Health	NNP
cord-006702-ekf6mja9	775	77	,	,	,
cord-006702-ekf6mja9	775	78	Baltimore	Baltimore	NNP
cord-006702-ekf6mja9	775	79	,	,	,
cord-006702-ekf6mja9	775	80	United	United	NNP
cord-006702-ekf6mja9	775	81	States	States	NNP
cord-006702-ekf6mja9	775	82	;	;	:
cord-006702-ekf6mja9	775	83	(	(	-LRB-
cord-006702-ekf6mja9	775	84	3	3	LS
cord-006702-ekf6mja9	775	85	)	)	-RRB-
cord-006702-ekf6mja9	775	86	University	University	NNP
cord-006702-ekf6mja9	775	87	of	of	IN
cord-006702-ekf6mja9	775	88	Pennsylvania	Pennsylvania	NNP
cord-006702-ekf6mja9	775	89	School	School	NNP
cord-006702-ekf6mja9	775	90	of	of	IN
cord-006702-ekf6mja9	775	91	Medicine	Medicine	NNP
cord-006702-ekf6mja9	775	92	and	and	CC
cord-006702-ekf6mja9	775	93	the	the	DT
cord-006702-ekf6mja9	775	94	Children	Children	NNPS
cord-006702-ekf6mja9	775	95	's	's	POS
cord-006702-ekf6mja9	775	96	Hospital	Hospital	NNP
cord-006702-ekf6mja9	775	97	of	of	IN
cord-006702-ekf6mja9	775	98	Philadelphia	Philadelphia	NNP
cord-006702-ekf6mja9	775	99	,	,	,
cord-006702-ekf6mja9	775	100	Philadelphia	Philadelphia	NNP
cord-006702-ekf6mja9	775	101	,	,	,
cord-006702-ekf6mja9	775	102	United	United	NNP
cord-006702-ekf6mja9	775	103	States	States	NNP
cord-006702-ekf6mja9	775	104	;	;	:
cord-006702-ekf6mja9	775	105	(	(	-LRB-
cord-006702-ekf6mja9	775	106	4	4	LS
cord-006702-ekf6mja9	775	107	)	)	-RRB-
cord-006702-ekf6mja9	775	108	Emory	Emory	NNP
cord-006702-ekf6mja9	775	109	University	University	NNP
cord-006702-ekf6mja9	775	110	School	School	NNP
cord-006702-ekf6mja9	775	111	of	of	IN
cord-006702-ekf6mja9	775	112	Medicine	Medicine	NNP
cord-006702-ekf6mja9	775	113	,	,	,
cord-006702-ekf6mja9	775	114	Atlanta	Atlanta	NNP
cord-006702-ekf6mja9	775	115	,	,	,
cord-006702-ekf6mja9	775	116	United	United	NNP
cord-006702-ekf6mja9	775	117	States	States	NNP
cord-006702-ekf6mja9	775	118	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	775	119	:	:	:
cord-006702-ekf6mja9	776	1	There	there	EX
cord-006702-ekf6mja9	776	2	is	be	VBZ
cord-006702-ekf6mja9	776	3	a	a	DT
cord-006702-ekf6mja9	776	4	disproportionate	disproportionate	JJ
cord-006702-ekf6mja9	776	5	burden	burden	NN
cord-006702-ekf6mja9	776	6	of	of	IN
cord-006702-ekf6mja9	776	7	human	human	JJ
cord-006702-ekf6mja9	776	8	papillomavirus	papillomavirus	NN
cord-006702-ekf6mja9	776	9	(	(	-LRB-
cord-006702-ekf6mja9	776	10	HPV)related	HPV)related	NNP
cord-006702-ekf6mja9	776	11	genital	genital	JJ
cord-006702-ekf6mja9	776	12	tract	tract	NN
cord-006702-ekf6mja9	776	13	disease	disease	NN
cord-006702-ekf6mja9	776	14	in	in	IN
cord-006702-ekf6mja9	776	15	patients	patient	NNS
cord-006702-ekf6mja9	776	16	with	with	IN
cord-006702-ekf6mja9	776	17	CKD	CKD	NNP
cord-006702-ekf6mja9	776	18	and	and	CC
cord-006702-ekf6mja9	776	19	kidney	kidney	NN
cord-006702-ekf6mja9	776	20	transplantation	transplantation	NN
cord-006702-ekf6mja9	776	21	,	,	,
cord-006702-ekf6mja9	776	22	therefore	therefore	RB
cord-006702-ekf6mja9	776	23	the	the	DT
cord-006702-ekf6mja9	776	24	potential	potential	JJ
cord-006702-ekf6mja9	776	25	impact	impact	NN
cord-006702-ekf6mja9	776	26	of	of	IN
cord-006702-ekf6mja9	776	27	the	the	DT
cord-006702-ekf6mja9	776	28	quadrivalent	quadrivalent	NN
cord-006702-ekf6mja9	776	29	HPV	HPV	NNP
cord-006702-ekf6mja9	776	30	vaccine	vaccine	NN
cord-006702-ekf6mja9	776	31	(	(	-LRB-
cord-006702-ekf6mja9	776	32	Gardasil	Gardasil	NNP
cord-006702-ekf6mja9	776	33	®	®	POS
cord-006702-ekf6mja9	776	34	)	)	-RRB-
cord-006702-ekf6mja9	776	35	is	be	VBZ
cord-006702-ekf6mja9	776	36	profound	profound	JJ
cord-006702-ekf6mja9	776	37	.	.	.
cord-006702-ekf6mja9	777	1	Immune	immune	JJ
cord-006702-ekf6mja9	777	2	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	777	3	associated	associate	VBN
cord-006702-ekf6mja9	777	4	with	with	IN
cord-006702-ekf6mja9	777	5	CKD	CKD	NNP
cord-006702-ekf6mja9	777	6	and	and	CC
cord-006702-ekf6mja9	777	7	immunosuppression	immunosuppression	NN
cord-006702-ekf6mja9	777	8	may	may	MD
cord-006702-ekf6mja9	777	9	prevent	prevent	VB
cord-006702-ekf6mja9	777	10	optimal	optimal	JJ
cord-006702-ekf6mja9	777	11	vaccine	vaccine	NN
cord-006702-ekf6mja9	777	12	response	response	NN
cord-006702-ekf6mja9	777	13	.	.	.
cord-006702-ekf6mja9	778	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	778	2	objective	objective	NN
cord-006702-ekf6mja9	778	3	was	be	VBD
cord-006702-ekf6mja9	778	4	to	to	TO
cord-006702-ekf6mja9	778	5	determine	determine	VB
cord-006702-ekf6mja9	778	6	antibody	antibody	NN
cord-006702-ekf6mja9	778	7	response	response	NN
cord-006702-ekf6mja9	778	8	to	to	IN
cord-006702-ekf6mja9	778	9	the	the	DT
cord-006702-ekf6mja9	778	10	HPV	HPV	NNP
cord-006702-ekf6mja9	778	11	vaccine	vaccine	NN
cord-006702-ekf6mja9	778	12	in	in	IN
cord-006702-ekf6mja9	778	13	female	female	JJ
cord-006702-ekf6mja9	778	14	adolescents	adolescent	NNS
cord-006702-ekf6mja9	778	15	with	with	IN
cord-006702-ekf6mja9	778	16	CKD	CKD	NNP
cord-006702-ekf6mja9	778	17	.	.	.
cord-006702-ekf6mja9	779	1	Methods	method	NNS
cord-006702-ekf6mja9	779	2	:	:	:
cord-006702-ekf6mja9	779	3	Cohort	cohort	NN
cord-006702-ekf6mja9	779	4	study	study	NN
cord-006702-ekf6mja9	779	5	conducted	conduct	VBN
cord-006702-ekf6mja9	779	6	from	from	IN
cord-006702-ekf6mja9	779	7	2008	2008	CD
cord-006702-ekf6mja9	779	8	-	-	SYM
cord-006702-ekf6mja9	779	9	2012	2012	CD
cord-006702-ekf6mja9	779	10	of	of	IN
cord-006702-ekf6mja9	779	11	57	57	CD
cord-006702-ekf6mja9	779	12	female	female	JJ
cord-006702-ekf6mja9	779	13	patients	patient	NNS
cord-006702-ekf6mja9	779	14	age	age	NN
cord-006702-ekf6mja9	779	15	9	9	CD
cord-006702-ekf6mja9	779	16	-	-	SYM
cord-006702-ekf6mja9	779	17	21	21	CD
cord-006702-ekf6mja9	779	18	years	year	NNS
cord-006702-ekf6mja9	779	19	recruited	recruit	VBN
cord-006702-ekf6mja9	779	20	from	from	IN
cord-006702-ekf6mja9	779	21	2	2	CD
cord-006702-ekf6mja9	779	22	pediatric	pediatric	JJ
cord-006702-ekf6mja9	779	23	nephrology	nephrology	NN
cord-006702-ekf6mja9	779	24	clinics	clinic	NNS
cord-006702-ekf6mja9	779	25	with	with	IN
cord-006702-ekf6mja9	779	26	CKD	CKD	NNP
cord-006702-ekf6mja9	779	27	(	(	-LRB-
cord-006702-ekf6mja9	779	28	n=25	n=25	NNP
cord-006702-ekf6mja9	779	29	)	)	-RRB-
cord-006702-ekf6mja9	779	30	,	,	,
cord-006702-ekf6mja9	779	31	on	on	IN
cord-006702-ekf6mja9	779	32	dialysis	dialysis	NN
cord-006702-ekf6mja9	779	33	(	(	-LRB-
cord-006702-ekf6mja9	779	34	n=9	n=9	NN
cord-006702-ekf6mja9	779	35	)	)	-RRB-
cord-006702-ekf6mja9	779	36	,	,	,
cord-006702-ekf6mja9	779	37	or	or	CC
cord-006702-ekf6mja9	779	38	status	status	NN
cord-006702-ekf6mja9	779	39	post	post	AFX
cord-006702-ekf6mja9	779	40	kidney	kidney	NN
cord-006702-ekf6mja9	779	41	transplantation	transplantation	NN
cord-006702-ekf6mja9	779	42	(	(	-LRB-
cord-006702-ekf6mja9	779	43	n=23	n=23	NNP
cord-006702-ekf6mja9	779	44	)	)	-RRB-
cord-006702-ekf6mja9	779	45	who	who	WP
cord-006702-ekf6mja9	779	46	received	receive	VBD
cord-006702-ekf6mja9	779	47	the	the	DT
cord-006702-ekf6mja9	779	48	standard	standard	JJ
cord-006702-ekf6mja9	779	49	3-dose	3-dose	CD
cord-006702-ekf6mja9	779	50	vaccine	vaccine	NN
cord-006702-ekf6mja9	779	51	series	series	NN
cord-006702-ekf6mja9	779	52	of	of	IN
cord-006702-ekf6mja9	779	53	the	the	DT
cord-006702-ekf6mja9	779	54	HPV	HPV	NNP
cord-006702-ekf6mja9	779	55	vaccine	vaccine	NN
cord-006702-ekf6mja9	779	56	.	.	.
cord-006702-ekf6mja9	780	1	Antibody	antibody	NN
cord-006702-ekf6mja9	780	2	levels	level	NNS
cord-006702-ekf6mja9	780	3	to	to	IN
cord-006702-ekf6mja9	780	4	HPV	hpv	NN
cord-006702-ekf6mja9	780	5	genotypes	genotype	NNS
cord-006702-ekf6mja9	780	6	6	6	CD
cord-006702-ekf6mja9	780	7	,	,	,
cord-006702-ekf6mja9	780	8	11	11	CD
cord-006702-ekf6mja9	780	9	,	,	,
cord-006702-ekf6mja9	780	10	16	16	CD
cord-006702-ekf6mja9	780	11	,	,	,
cord-006702-ekf6mja9	780	12	18	18	CD
cord-006702-ekf6mja9	780	13	were	be	VBD
cord-006702-ekf6mja9	780	14	measured	measure	VBN
cord-006702-ekf6mja9	780	15	prior	prior	RB
cord-006702-ekf6mja9	780	16	to	to	IN
cord-006702-ekf6mja9	780	17	vaccine	vaccine	NN
cord-006702-ekf6mja9	780	18	dose	dose	NN
cord-006702-ekf6mja9	780	19	1	1	CD
cord-006702-ekf6mja9	780	20	(	(	-LRB-
cord-006702-ekf6mja9	780	21	baseline	baseline	NN
cord-006702-ekf6mja9	780	22	)	)	-RRB-
cord-006702-ekf6mja9	780	23	,	,	,
cord-006702-ekf6mja9	780	24	less	less	JJR
cord-006702-ekf6mja9	780	25	than	than	IN
cord-006702-ekf6mja9	780	26	12	12	CD
cord-006702-ekf6mja9	780	27	months	month	NNS
cord-006702-ekf6mja9	780	28	after	after	IN
cord-006702-ekf6mja9	780	29	vaccine	vaccine	NN
cord-006702-ekf6mja9	780	30	dose	dose	NN
cord-006702-ekf6mja9	780	31	3	3	CD
cord-006702-ekf6mja9	780	32	(	(	-LRB-
cord-006702-ekf6mja9	780	33	blood	blood	NN
cord-006702-ekf6mja9	780	34	draw	draw	VB
cord-006702-ekf6mja9	780	35	2	2	CD
cord-006702-ekf6mja9	780	36	)	)	-RRB-
cord-006702-ekf6mja9	780	37	,	,	,
cord-006702-ekf6mja9	780	38	and	and	CC
cord-006702-ekf6mja9	780	39	12	12	CD
cord-006702-ekf6mja9	780	40	months	month	NNS
cord-006702-ekf6mja9	780	41	or	or	CC
cord-006702-ekf6mja9	780	42	greater	great	JJR
cord-006702-ekf6mja9	780	43	after	after	IN
cord-006702-ekf6mja9	780	44	vaccine	vaccine	NN
cord-006702-ekf6mja9	780	45	dose	dose	NN
cord-006702-ekf6mja9	780	46	3	3	CD
cord-006702-ekf6mja9	780	47	(	(	-LRB-
cord-006702-ekf6mja9	780	48	blood	blood	NN
cord-006702-ekf6mja9	780	49	draw	draw	VB
cord-006702-ekf6mja9	780	50	3	3	CD
cord-006702-ekf6mja9	780	51	)	)	-RRB-
cord-006702-ekf6mja9	780	52	.	.	.
cord-006702-ekf6mja9	781	1	Seropositivity	Seropositivity	NNP
cord-006702-ekf6mja9	781	2	was	be	VBD
cord-006702-ekf6mja9	781	3	defined	define	VBN
cord-006702-ekf6mja9	781	4	as	as	IN
cord-006702-ekf6mja9	781	5	antibody	antibody	NN
cord-006702-ekf6mja9	781	6	level	level	NN
cord-006702-ekf6mja9	781	7	above	above	IN
cord-006702-ekf6mja9	781	8	an	an	DT
cord-006702-ekf6mja9	781	9	established	establish	VBN
cord-006702-ekf6mja9	781	10	threshold	threshold	NN
cord-006702-ekf6mja9	781	11	for	for	IN
cord-006702-ekf6mja9	781	12	each	each	DT
cord-006702-ekf6mja9	781	13	HPV	HPV	NNP
cord-006702-ekf6mja9	781	14	genotype	genotype	NN
cord-006702-ekf6mja9	781	15	.	.	.
cord-006702-ekf6mja9	782	1	Not	not	RB
cord-006702-ekf6mja9	782	2	all	all	DT
cord-006702-ekf6mja9	782	3	participants	participant	NNS
cord-006702-ekf6mja9	782	4	completed	complete	VBD
cord-006702-ekf6mja9	782	5	3	3	CD
cord-006702-ekf6mja9	782	6	blood	blood	NN
cord-006702-ekf6mja9	782	7	draws	draw	NNS
cord-006702-ekf6mja9	782	8	.	.	.
cord-006702-ekf6mja9	783	1	&	&	CC
cord-006702-ekf6mja9	783	2	BD	BD	NNP
cord-006702-ekf6mja9	783	3	,	,	,
cord-006702-ekf6mja9	783	4	blood	blood	NN
cord-006702-ekf6mja9	783	5	draw	draw	NN
cord-006702-ekf6mja9	783	6	;	;	:
cord-006702-ekf6mja9	783	7	V	v	NN
cord-006702-ekf6mja9	783	8	,	,	,
cord-006702-ekf6mja9	783	9	vaccine	vaccine	NN
cord-006702-ekf6mja9	783	10	Results	result	NNS
cord-006702-ekf6mja9	783	11	:	:	:
cord-006702-ekf6mja9	784	1	Antibody	antibody	NN
cord-006702-ekf6mja9	784	2	response	response	NN
cord-006702-ekf6mja9	784	3	to	to	IN
cord-006702-ekf6mja9	784	4	all	all	DT
cord-006702-ekf6mja9	784	5	4	4	CD
cord-006702-ekf6mja9	784	6	HPV	HPV	NNP
cord-006702-ekf6mja9	784	7	genotypes	genotype	NNS
cord-006702-ekf6mja9	784	8	was	be	VBD
cord-006702-ekf6mja9	784	9	100	100	CD
cord-006702-ekf6mja9	784	10	%	%	NN
cord-006702-ekf6mja9	784	11	in	in	IN
cord-006702-ekf6mja9	784	12	the	the	DT
cord-006702-ekf6mja9	784	13	CKD	CKD	NNP
cord-006702-ekf6mja9	784	14	and	and	CC
cord-006702-ekf6mja9	784	15	dialysis	dialysis	NN
cord-006702-ekf6mja9	784	16	groups	group	NNS
cord-006702-ekf6mja9	784	17	with	with	IN
cord-006702-ekf6mja9	784	18	samples	sample	NNS
cord-006702-ekf6mja9	784	19	drawn	draw	VBN
cord-006702-ekf6mja9	784	20	at	at	IN
cord-006702-ekf6mja9	784	21	<	<	$
cord-006702-ekf6mja9	784	22	12	12	CD
cord-006702-ekf6mja9	784	23	months	month	NNS
cord-006702-ekf6mja9	784	24	and	and	CC
cord-006702-ekf6mja9	784	25	≥12	≥12	NNP
cord-006702-ekf6mja9	784	26	months	month	NNS
cord-006702-ekf6mja9	784	27	after	after	IN
cord-006702-ekf6mja9	784	28	dose	dose	NN
cord-006702-ekf6mja9	784	29	3	3	CD
cord-006702-ekf6mja9	784	30	of	of	IN
cord-006702-ekf6mja9	784	31	the	the	DT
cord-006702-ekf6mja9	784	32	HPV	HPV	NNP
cord-006702-ekf6mja9	784	33	vaccine	vaccine	NN
cord-006702-ekf6mja9	784	34	.	.	.
cord-006702-ekf6mja9	785	1	Among	among	IN
cord-006702-ekf6mja9	785	2	the	the	DT
cord-006702-ekf6mja9	785	3	transplant	transplant	NN
cord-006702-ekf6mja9	785	4	patients	patient	NNS
cord-006702-ekf6mja9	785	5	,	,	,
cord-006702-ekf6mja9	785	6	the	the	DT
cord-006702-ekf6mja9	785	7	percent	percent	NN
cord-006702-ekf6mja9	785	8	of	of	IN
cord-006702-ekf6mja9	785	9	patients	patient	NNS
cord-006702-ekf6mja9	785	10	achieving	achieve	VBG
cord-006702-ekf6mja9	785	11	seropositivity	seropositivity	NN
cord-006702-ekf6mja9	785	12	was	be	VBD
cord-006702-ekf6mja9	785	13	significantly	significantly	RB
cord-006702-ekf6mja9	785	14	lower	low	JJR
cord-006702-ekf6mja9	785	15	at	at	IN
cord-006702-ekf6mja9	785	16	blood	blood	NN
cord-006702-ekf6mja9	785	17	draw	draw	NN
cord-006702-ekf6mja9	785	18	2	2	CD
cord-006702-ekf6mja9	785	19	for	for	IN
cord-006702-ekf6mja9	785	20	HPV	hpv	NN
cord-006702-ekf6mja9	785	21	genotypes	genotype	NNS
cord-006702-ekf6mja9	785	22	6	6	CD
cord-006702-ekf6mja9	785	23	(	(	-LRB-
cord-006702-ekf6mja9	785	24	63.6	63.6	CD
cord-006702-ekf6mja9	785	25	%	%	NN
cord-006702-ekf6mja9	785	26	,	,	,
cord-006702-ekf6mja9	785	27	p=0.003	p=0.003	NNP
cord-006702-ekf6mja9	785	28	)	)	-RRB-
cord-006702-ekf6mja9	785	29	,	,	,
cord-006702-ekf6mja9	785	30	11	11	CD
cord-006702-ekf6mja9	785	31	(	(	-LRB-
cord-006702-ekf6mja9	785	32	63.6	63.6	CD
cord-006702-ekf6mja9	785	33	%	%	NN
cord-006702-ekf6mja9	785	34	,	,	,
cord-006702-ekf6mja9	785	35	p=0.003	p=0.003	NNP
cord-006702-ekf6mja9	785	36	)	)	-RRB-
cord-006702-ekf6mja9	785	37	and	and	CC
cord-006702-ekf6mja9	785	38	18	18	CD
cord-006702-ekf6mja9	785	39	(	(	-LRB-
cord-006702-ekf6mja9	785	40	72.7	72.7	CD
cord-006702-ekf6mja9	785	41	%	%	NN
cord-006702-ekf6mja9	785	42	,	,	,
cord-006702-ekf6mja9	785	43	p=0.02	p=0.02	NN
cord-006702-ekf6mja9	785	44	)	)	-RRB-
cord-006702-ekf6mja9	785	45	and	and	CC
cord-006702-ekf6mja9	785	46	blood	blood	NN
cord-006702-ekf6mja9	785	47	draw	draw	VBP
cord-006702-ekf6mja9	785	48	3	3	CD
cord-006702-ekf6mja9	785	49	for	for	IN
cord-006702-ekf6mja9	785	50	HPV	hpv	NN
cord-006702-ekf6mja9	785	51	genotypes	genotype	NNS
cord-006702-ekf6mja9	785	52	6	6	CD
cord-006702-ekf6mja9	785	53	(	(	-LRB-
cord-006702-ekf6mja9	785	54	62.5	62.5	CD
cord-006702-ekf6mja9	785	55	%	%	NN
cord-006702-ekf6mja9	785	56	,	,	,
cord-006702-ekf6mja9	785	57	p=0.02	p=0.02	NNP
cord-006702-ekf6mja9	785	58	)	)	-RRB-
cord-006702-ekf6mja9	785	59	,	,	,
cord-006702-ekf6mja9	785	60	11	11	CD
cord-006702-ekf6mja9	785	61	(	(	-LRB-
cord-006702-ekf6mja9	785	62	50	50	CD
cord-006702-ekf6mja9	785	63	%	%	NN
cord-006702-ekf6mja9	785	64	,	,	,
cord-006702-ekf6mja9	785	65	p=0.001	p=0.001	NNP
cord-006702-ekf6mja9	785	66	)	)	-RRB-
cord-006702-ekf6mja9	785	67	,	,	,
cord-006702-ekf6mja9	785	68	16	16	CD
cord-006702-ekf6mja9	785	69	(	(	-LRB-
cord-006702-ekf6mja9	785	70	75	75	CD
cord-006702-ekf6mja9	785	71	%	%	NN
cord-006702-ekf6mja9	785	72	,	,	,
cord-006702-ekf6mja9	785	73	p=0.04	p=0.04	NNP
cord-006702-ekf6mja9	785	74	)	)	-RRB-
cord-006702-ekf6mja9	785	75	,	,	,
cord-006702-ekf6mja9	785	76	and	and	CC
cord-006702-ekf6mja9	785	77	18	18	CD
cord-006702-ekf6mja9	785	78	(	(	-LRB-
cord-006702-ekf6mja9	785	79	50	50	CD
cord-006702-ekf6mja9	785	80	%	%	NN
cord-006702-ekf6mja9	785	81	,	,	,
cord-006702-ekf6mja9	785	82	p=0.001	p=0.001	NNP
cord-006702-ekf6mja9	785	83	)	)	-RRB-
cord-006702-ekf6mja9	785	84	.	.	.
cord-006702-ekf6mja9	786	1	&	&	CC
cord-006702-ekf6mja9	786	2	Whiskers	Whiskers	NNPS
cord-006702-ekf6mja9	786	3	represent	represent	VBP
cord-006702-ekf6mja9	786	4	the	the	DT
cord-006702-ekf6mja9	786	5	25th	25th	JJ
cord-006702-ekf6mja9	786	6	or	or	CC
cord-006702-ekf6mja9	786	7	75th	75th	JJ
cord-006702-ekf6mja9	786	8	percentiles	percentile	NNS
cord-006702-ekf6mja9	786	9	+	+	CC
cord-006702-ekf6mja9	787	1	(	(	-LRB-
cord-006702-ekf6mja9	787	2	1.5x	1.5x	JJ
cord-006702-ekf6mja9	787	3	Interquartile	Interquartile	NNP
cord-006702-ekf6mja9	787	4	Range	Range	NNP
cord-006702-ekf6mja9	787	5	)	)	-RRB-
cord-006702-ekf6mja9	787	6	Antibody	antibody	NN
cord-006702-ekf6mja9	787	7	levels	level	NNS
cord-006702-ekf6mja9	787	8	in	in	IN
cord-006702-ekf6mja9	787	9	transplant	transplant	NN
cord-006702-ekf6mja9	787	10	patients	patient	NNS
cord-006702-ekf6mja9	787	11	compared	compare	VBN
cord-006702-ekf6mja9	787	12	to	to	IN
cord-006702-ekf6mja9	787	13	CKD	CKD	NNP
cord-006702-ekf6mja9	787	14	patients	patient	NNS
cord-006702-ekf6mja9	787	15	and	and	CC
cord-006702-ekf6mja9	787	16	to	to	IN
cord-006702-ekf6mja9	787	17	dialysis	dialysis	NN
cord-006702-ekf6mja9	787	18	patients	patient	NNS
cord-006702-ekf6mja9	787	19	for	for	IN
cord-006702-ekf6mja9	787	20	HPV	hpv	NN
cord-006702-ekf6mja9	787	21	genotypes	genotype	NNS
cord-006702-ekf6mja9	787	22	6	6	CD
cord-006702-ekf6mja9	787	23	,	,	,
cord-006702-ekf6mja9	787	24	11	11	CD
cord-006702-ekf6mja9	787	25	,	,	,
cord-006702-ekf6mja9	787	26	16	16	CD
cord-006702-ekf6mja9	787	27	,	,	,
cord-006702-ekf6mja9	787	28	18	18	CD
cord-006702-ekf6mja9	787	29	.	.	.
cord-006702-ekf6mja9	788	1	There	there	EX
cord-006702-ekf6mja9	788	2	was	be	VBD
cord-006702-ekf6mja9	788	3	no	no	DT
cord-006702-ekf6mja9	788	4	statistically	statistically	RB
cord-006702-ekf6mja9	788	5	significant	significant	JJ
cord-006702-ekf6mja9	788	6	difference	difference	NN
cord-006702-ekf6mja9	789	1	betw	betw	NNP
cord-006702-ekf6mja9	789	2	Conclusions	Conclusions	NNPS
cord-006702-ekf6mja9	789	3	:	:	:
cord-006702-ekf6mja9	790	1	Antibody	antibody	NN
cord-006702-ekf6mja9	790	2	response	response	NN
cord-006702-ekf6mja9	790	3	to	to	IN
cord-006702-ekf6mja9	790	4	the	the	DT
cord-006702-ekf6mja9	790	5	quadrivalent	quadrivalent	NN
cord-006702-ekf6mja9	790	6	recombinant	recombinant	JJ
cord-006702-ekf6mja9	790	7	HPV	HPV	NNP
cord-006702-ekf6mja9	790	8	vaccine	vaccine	NN
cord-006702-ekf6mja9	790	9	was	be	VBD
cord-006702-ekf6mja9	790	10	robust	robust	JJ
cord-006702-ekf6mja9	790	11	and	and	CC
cord-006702-ekf6mja9	790	12	sustained	sustain	VBN
cord-006702-ekf6mja9	790	13	in	in	IN
cord-006702-ekf6mja9	790	14	girls	girl	NNS
cord-006702-ekf6mja9	790	15	and	and	CC
cord-006702-ekf6mja9	790	16	young	young	JJ
cord-006702-ekf6mja9	790	17	women	woman	NNS
cord-006702-ekf6mja9	790	18	with	with	IN
cord-006702-ekf6mja9	790	19	CKD	CKD	NNP
cord-006702-ekf6mja9	790	20	and	and	CC
cord-006702-ekf6mja9	790	21	on	on	IN
cord-006702-ekf6mja9	790	22	dialysis	dialysis	NN
cord-006702-ekf6mja9	790	23	.	.	.
cord-006702-ekf6mja9	791	1	A	a	DT
cord-006702-ekf6mja9	791	2	less	less	RBR
cord-006702-ekf6mja9	791	3	robust	robust	JJ
cord-006702-ekf6mja9	791	4	response	response	NN
cord-006702-ekf6mja9	791	5	to	to	IN
cord-006702-ekf6mja9	791	6	the	the	DT
cord-006702-ekf6mja9	791	7	vaccine	vaccine	NN
cord-006702-ekf6mja9	791	8	was	be	VBD
cord-006702-ekf6mja9	791	9	observed	observe	VBN
cord-006702-ekf6mja9	791	10	among	among	IN
cord-006702-ekf6mja9	791	11	those	those	DT
cord-006702-ekf6mja9	791	12	with	with	IN
cord-006702-ekf6mja9	791	13	a	a	DT
cord-006702-ekf6mja9	791	14	kidney	kidney	NN
cord-006702-ekf6mja9	791	15	transplant	transplant	NN
cord-006702-ekf6mja9	791	16	.	.	.
cord-006702-ekf6mja9	792	1	Further	further	JJ
cord-006702-ekf6mja9	792	2	study	study	NN
cord-006702-ekf6mja9	792	3	is	be	VBZ
cord-006702-ekf6mja9	792	4	needed	need	VBN
cord-006702-ekf6mja9	792	5	to	to	TO
cord-006702-ekf6mja9	792	6	determine	determine	VB
cord-006702-ekf6mja9	792	7	if	if	IN
cord-006702-ekf6mja9	792	8	vaccination	vaccination	NN
cord-006702-ekf6mja9	792	9	before	before	IN
cord-006702-ekf6mja9	792	10	kidney	kidney	NN
cord-006702-ekf6mja9	792	11	transplantation	transplantation	NN
cord-006702-ekf6mja9	792	12	or	or	CC
cord-006702-ekf6mja9	792	13	an	an	DT
cord-006702-ekf6mja9	792	14	alternative	alternative	JJ
cord-006702-ekf6mja9	792	15	vaccination	vaccination	NN
cord-006702-ekf6mja9	792	16	regimen	regimen	NN
cord-006702-ekf6mja9	792	17	would	would	MD
cord-006702-ekf6mja9	792	18	benefit	benefit	VB
cord-006702-ekf6mja9	792	19	transplant	transplant	NN
cord-006702-ekf6mja9	792	20	recipients	recipient	NNS
cord-006702-ekf6mja9	792	21	.	.	.
cord-006702-ekf6mja9	792	22	 	 	_SP
cord-006702-ekf6mja9	793	1	Chronic	chronic	JJ
cord-006702-ekf6mja9	793	2	kidney	kidney	NN
cord-006702-ekf6mja9	793	3	disease	disease	NN
cord-006702-ekf6mja9	793	4	can	can	MD
cord-006702-ekf6mja9	793	5	be	be	VB
cord-006702-ekf6mja9	793	6	identified	identify	VBN
cord-006702-ekf6mja9	793	7	reliably	reliably	RB
cord-006702-ekf6mja9	793	8	by	by	IN
cord-006702-ekf6mja9	793	9	urinary	urinary	JJ
cord-006702-ekf6mja9	793	10	proteome	proteome	NN
cord-006702-ekf6mja9	793	11	analysis	analysis	NN
cord-006702-ekf6mja9	793	12	in	in	IN
cord-006702-ekf6mja9	793	13	children	child	NNS
cord-006702-ekf6mja9	793	14	after	after	IN
cord-006702-ekf6mja9	793	15	orthotopic	orthotopic	NNP
cord-006702-ekf6mja9	793	16	liver	liver	NN
cord-006702-ekf6mja9	793	17	transplantation	transplantation	NN
cord-006702-ekf6mja9	793	18	J.	J.	NNP
cord-006702-ekf6mja9	793	19	Drube	Drube	NNP
cord-006702-ekf6mja9	793	20	(	(	-LRB-
cord-006702-ekf6mja9	793	21	1	1	CD
cord-006702-ekf6mja9	793	22	)	)	-RRB-
cord-006702-ekf6mja9	793	23	,	,	,
cord-006702-ekf6mja9	793	24	P.	P.	NNP
cord-006702-ekf6mja9	793	25	Zuerbig	Zuerbig	NNP
cord-006702-ekf6mja9	793	26	(	(	-LRB-
cord-006702-ekf6mja9	793	27	2	2	CD
cord-006702-ekf6mja9	793	28	)	)	-RRB-
cord-006702-ekf6mja9	793	29	,	,	,
cord-006702-ekf6mja9	793	30	H.	H.	NNP
cord-006702-ekf6mja9	793	31	Mischak	Mischak	NNP
cord-006702-ekf6mja9	793	32	(	(	-LRB-
cord-006702-ekf6mja9	793	33	2	2	CD
cord-006702-ekf6mja9	793	34	)	)	-RRB-
cord-006702-ekf6mja9	793	35	,	,	,
cord-006702-ekf6mja9	793	36	L.	L.	NNP
cord-006702-ekf6mja9	793	37	Pape	Pape	NNP
cord-006702-ekf6mja9	793	38	(	(	-LRB-
cord-006702-ekf6mja9	793	39	1	1	CD
cord-006702-ekf6mja9	793	40	)	)	-RRB-
cord-006702-ekf6mja9	793	41	(	(	-LRB-
cord-006702-ekf6mja9	793	42	1	1	LS
cord-006702-ekf6mja9	793	43	)	)	-RRB-
cord-006702-ekf6mja9	793	44	Hannover	Hannover	NNP
cord-006702-ekf6mja9	793	45	Medical	Medical	NNP
cord-006702-ekf6mja9	793	46	School	School	NNP
cord-006702-ekf6mja9	793	47	,	,	,
cord-006702-ekf6mja9	793	48	Hannover	Hannover	NNP
cord-006702-ekf6mja9	793	49	,	,	,
cord-006702-ekf6mja9	793	50	Germany	Germany	NNP
cord-006702-ekf6mja9	793	51	;	;	:
cord-006702-ekf6mja9	793	52	(	(	-LRB-
cord-006702-ekf6mja9	793	53	2	2	LS
cord-006702-ekf6mja9	793	54	)	)	-RRB-
cord-006702-ekf6mja9	793	55	Mosaiques	Mosaiques	NNP
cord-006702-ekf6mja9	793	56	diagnostics	diagnostic	NNS
cord-006702-ekf6mja9	793	57	GmbH	GmbH	NNP
cord-006702-ekf6mja9	793	58	,	,	,
cord-006702-ekf6mja9	793	59	Hannover	Hannover	NNP
cord-006702-ekf6mja9	793	60	,	,	,
cord-006702-ekf6mja9	793	61	Germany	Germany	NNP
cord-006702-ekf6mja9	793	62	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	793	63	:	:	:
cord-006702-ekf6mja9	793	64	Chronic	chronic	JJ
cord-006702-ekf6mja9	793	65	kidney	kidney	NN
cord-006702-ekf6mja9	793	66	disease	disease	NN
cord-006702-ekf6mja9	793	67	(	(	-LRB-
cord-006702-ekf6mja9	793	68	CKD	CKD	NNP
cord-006702-ekf6mja9	793	69	)	)	-RRB-
cord-006702-ekf6mja9	793	70	is	be	VBZ
cord-006702-ekf6mja9	793	71	a	a	DT
cord-006702-ekf6mja9	793	72	common	common	JJ
cord-006702-ekf6mja9	793	73	cause	cause	NN
cord-006702-ekf6mja9	793	74	for	for	IN
cord-006702-ekf6mja9	793	75	morbidity	morbidity	NN
cord-006702-ekf6mja9	793	76	and	and	CC
cord-006702-ekf6mja9	793	77	mortality	mortality	NN
cord-006702-ekf6mja9	793	78	not	not	RB
cord-006702-ekf6mja9	793	79	related	relate	VBN
cord-006702-ekf6mja9	793	80	to	to	IN
cord-006702-ekf6mja9	793	81	the	the	DT
cord-006702-ekf6mja9	793	82	primary	primary	JJ
cord-006702-ekf6mja9	793	83	disease	disease	NN
cord-006702-ekf6mja9	793	84	inchildren	inchildren	NNS
cord-006702-ekf6mja9	793	85	after	after	IN
cord-006702-ekf6mja9	793	86	solid	solid	JJ
cord-006702-ekf6mja9	793	87	organ	organ	NN
cord-006702-ekf6mja9	793	88	transplantation	transplantation	NN
cord-006702-ekf6mja9	793	89	.	.	.
cord-006702-ekf6mja9	794	1	A	a	DT
cord-006702-ekf6mja9	794	2	urinary	urinary	JJ
cord-006702-ekf6mja9	794	3	proteome	proteome	NN
cord-006702-ekf6mja9	794	4	pattern	pattern	NN
cord-006702-ekf6mja9	794	5	publishedby	publishedby	NN
cord-006702-ekf6mja9	794	6	Good	Good	NNP
cord-006702-ekf6mja9	794	7	et	et	FW
cord-006702-ekf6mja9	794	8	al	al	NNP
cord-006702-ekf6mja9	794	9	.	.	NNP
cord-006702-ekf6mja9	794	10	was	be	VBD
cord-006702-ekf6mja9	794	11	shown	show	VBN
cord-006702-ekf6mja9	794	12	to	to	TO
cord-006702-ekf6mja9	794	13	identify	identify	VB
cord-006702-ekf6mja9	794	14	adult	adult	NN
cord-006702-ekf6mja9	794	15	patients	patient	NNS
cord-006702-ekf6mja9	794	16	with	with	IN
cord-006702-ekf6mja9	794	17	primary	primary	JJ
cord-006702-ekf6mja9	794	18	CKD	CKD	NNP
cord-006702-ekf6mja9	794	19	with	with	IN
cord-006702-ekf6mja9	794	20	higher	high	JJR
cord-006702-ekf6mja9	794	21	reliability	reliability	NN
cord-006702-ekf6mja9	794	22	than	than	IN
cord-006702-ekf6mja9	794	23	creatinine	creatinine	NN
cord-006702-ekf6mja9	794	24	based	base	VBN
cord-006702-ekf6mja9	794	25	methods	method	NNS
cord-006702-ekf6mja9	794	26	.	.	.
cord-006702-ekf6mja9	795	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	795	2	study	study	NN
cord-006702-ekf6mja9	795	3	aimed	aim	VBD
cord-006702-ekf6mja9	795	4	to	to	IN
cord-006702-ekf6mja9	795	5	proof	proof	NN
cord-006702-ekf6mja9	795	6	this	this	DT
cord-006702-ekf6mja9	795	7	pattern	pattern	NN
cord-006702-ekf6mja9	795	8	's	's	POS
cord-006702-ekf6mja9	795	9	reliability	reliability	NN
cord-006702-ekf6mja9	795	10	in	in	IN
cord-006702-ekf6mja9	795	11	pediatric	pediatric	JJ
cord-006702-ekf6mja9	795	12	patients	patient	NNS
cord-006702-ekf6mja9	795	13	following	follow	VBG
cord-006702-ekf6mja9	795	14	orthotopic	orthotopic	JJ
cord-006702-ekf6mja9	795	15	liver	liver	NN
cord-006702-ekf6mja9	795	16	transplantation	transplantation	NN
cord-006702-ekf6mja9	795	17	(	(	-LRB-
cord-006702-ekf6mja9	795	18	pOLT	polt	NN
cord-006702-ekf6mja9	795	19	)	)	-RRB-
cord-006702-ekf6mja9	795	20	.	.	.
cord-006702-ekf6mja9	796	1	In	in	IN
cord-006702-ekf6mja9	796	2	this	this	DT
cord-006702-ekf6mja9	796	3	population	population	NN
cord-006702-ekf6mja9	796	4	kidney	kidney	NN
cord-006702-ekf6mja9	796	5	function	function	NN
cord-006702-ekf6mja9	796	6	is	be	VBZ
cord-006702-ekf6mja9	796	7	usually	usually	RB
cord-006702-ekf6mja9	796	8	over	over	RB
cord-006702-ekf6mja9	796	9	-	-	HYPH
cord-006702-ekf6mja9	796	10	estimated	estimate	VBN
cord-006702-ekf6mja9	796	11	by	by	IN
cord-006702-ekf6mja9	796	12	creatinine	creatinine	NN
cord-006702-ekf6mja9	796	13	based	base	VBN
cord-006702-ekf6mja9	796	14	methods	method	NNS
cord-006702-ekf6mja9	796	15	due	due	JJ
cord-006702-ekf6mja9	796	16	to	to	IN
cord-006702-ekf6mja9	796	17	extreme	extreme	JJ
cord-006702-ekf6mja9	796	18	low	low	JJ
cord-006702-ekf6mja9	796	19	muscle	muscle	NN
cord-006702-ekf6mja9	796	20	mass	mass	NN
cord-006702-ekf6mja9	796	21	of	of	IN
cord-006702-ekf6mja9	796	22	the	the	DT
cord-006702-ekf6mja9	796	23	patients	patient	NNS
cord-006702-ekf6mja9	796	24	.	.	.
cord-006702-ekf6mja9	797	1	Methods	method	NNS
cord-006702-ekf6mja9	797	2	:	:	:
cord-006702-ekf6mja9	798	1	The	the	DT
cord-006702-ekf6mja9	798	2	urinary	urinary	JJ
cord-006702-ekf6mja9	798	3	proteome	proteome	NN
cord-006702-ekf6mja9	798	4	patterns	pattern	NNS
cord-006702-ekf6mja9	798	5	of	of	IN
cord-006702-ekf6mja9	798	6	25	25	CD
cord-006702-ekf6mja9	798	7	children	child	NNS
cord-006702-ekf6mja9	798	8	with	with	IN
cord-006702-ekf6mja9	798	9	biliary	biliary	JJ
cord-006702-ekf6mja9	798	10	atresia	atresia	NN
cord-006702-ekf6mja9	798	11	followed	follow	VBN
cord-006702-ekf6mja9	798	12	by	by	IN
cord-006702-ekf6mja9	798	13	pediatric	pediatric	JJ
cord-006702-ekf6mja9	798	14	orthotopic	orthotopic	JJ
cord-006702-ekf6mja9	798	15	liver	liver	NN
cord-006702-ekf6mja9	798	16	transplantation	transplantation	NN
cord-006702-ekf6mja9	798	17	were	be	VBD
cord-006702-ekf6mja9	798	18	analyzed	analyze	VBN
cord-006702-ekf6mja9	798	19	by	by	IN
cord-006702-ekf6mja9	798	20	capillary	capillary	JJ
cord-006702-ekf6mja9	798	21	electrophoresis	electrophoresis	NN
cord-006702-ekf6mja9	798	22	coupled	couple	VBN
cord-006702-ekf6mja9	798	23	to	to	IN
cord-006702-ekf6mja9	798	24	mass	mass	NN
cord-006702-ekf6mja9	798	25	spectrometry	spectrometry	NN
cord-006702-ekf6mja9	798	26	and	and	CC
cord-006702-ekf6mja9	798	27	compared	compare	VBN
cord-006702-ekf6mja9	798	28	to	to	IN
cord-006702-ekf6mja9	798	29	the	the	DT
cord-006702-ekf6mja9	798	30	known	know	VBN
cord-006702-ekf6mja9	798	31	proteome	proteome	NN
cord-006702-ekf6mja9	798	32	pattern	pattern	NN
cord-006702-ekf6mja9	798	33	of	of	IN
cord-006702-ekf6mja9	798	34	CKD	CKD	NNP
cord-006702-ekf6mja9	798	35	.	.	.
cord-006702-ekf6mja9	799	1	Cystatin	Cystatin	NNP
cord-006702-ekf6mja9	799	2	C	C	NNP
cord-006702-ekf6mja9	799	3	based	base	VBD
cord-006702-ekf6mja9	799	4	estimated	estimate	VBD
cord-006702-ekf6mja9	799	5	glomerular	glomerular	JJ
cord-006702-ekf6mja9	799	6	filtration	filtration	NN
cord-006702-ekf6mja9	799	7	rate	rate	NN
cord-006702-ekf6mja9	799	8	(	(	-LRB-
cord-006702-ekf6mja9	799	9	eGFR	egfr	NN
cord-006702-ekf6mja9	799	10	)	)	-RRB-
cord-006702-ekf6mja9	799	11	was	be	VBD
cord-006702-ekf6mja9	799	12	chosen	choose	VBN
cord-006702-ekf6mja9	799	13	as	as	IN
cord-006702-ekf6mja9	799	14	comparator	comparator	NN
cord-006702-ekf6mja9	799	15	.	.	.
cord-006702-ekf6mja9	800	1	In	in	IN
cord-006702-ekf6mja9	800	2	addition	addition	NN
cord-006702-ekf6mja9	800	3	,	,	,
cord-006702-ekf6mja9	800	4	estimation	estimation	NN
cord-006702-ekf6mja9	800	5	of	of	IN
cord-006702-ekf6mja9	800	6	creatinine	creatinine	NN
cord-006702-ekf6mja9	800	7	based	base	VBN
cord-006702-ekf6mja9	800	8	GFR	GFR	NNP
cord-006702-ekf6mja9	800	9	was	be	VBD
cord-006702-ekf6mja9	800	10	also	also	RB
cord-006702-ekf6mja9	800	11	performed	perform	VBN
cord-006702-ekf6mja9	800	12	in	in	IN
cord-006702-ekf6mja9	800	13	all	all	DT
cord-006702-ekf6mja9	800	14	patients	patient	NNS
cord-006702-ekf6mja9	800	15	.	.	.
cord-006702-ekf6mja9	801	1	Results	result	NNS
cord-006702-ekf6mja9	801	2	:	:	:
cord-006702-ekf6mja9	802	1	Thirteen	thirteen	CD
cord-006702-ekf6mja9	802	2	children	child	NNS
cord-006702-ekf6mja9	802	3	(	(	-LRB-
cord-006702-ekf6mja9	802	4	f	f	NNP
cord-006702-ekf6mja9	802	5	:	:	:
cord-006702-ekf6mja9	802	6	7	7	CD
cord-006702-ekf6mja9	802	7	;	;	:
cord-006702-ekf6mja9	802	8	median	median	NN
cord-006702-ekf6mja9	802	9	age	age	NN
cord-006702-ekf6mja9	802	10	7.9yrs	7.9yrs	NNP
cord-006702-ekf6mja9	802	11	.	.	.
cord-006702-ekf6mja9	802	12	;	;	:
cord-006702-ekf6mja9	802	13	range	range	VBP
cord-006702-ekf6mja9	802	14	0.6	0.6	CD
cord-006702-ekf6mja9	802	15	to	to	IN
cord-006702-ekf6mja9	802	16	15.4	15.4	CD
cord-006702-ekf6mja9	802	17	)	)	-RRB-
cord-006702-ekf6mja9	802	18	had	have	VBD
cord-006702-ekf6mja9	802	19	a	a	DT
cord-006702-ekf6mja9	802	20	reduced	reduce	VBN
cord-006702-ekf6mja9	802	21	cystatin	cystatin	NN
cord-006702-ekf6mja9	802	22	C	c	NN
cord-006702-ekf6mja9	802	23	GFR	GFR	NNP
cord-006702-ekf6mja9	802	24	below	below	IN
cord-006702-ekf6mja9	802	25	60	60	CD
cord-006702-ekf6mja9	802	26	ml	ml	NN
cord-006702-ekf6mja9	802	27	/	/	SYM
cord-006702-ekf6mja9	802	28	min/1.73	min/1.73	VBN
cord-006702-ekf6mja9	803	1	m	m	LS
cord-006702-ekf6mja9	803	2	2	2	CD
cord-006702-ekf6mja9	803	3	,	,	,
cord-006702-ekf6mja9	803	4	12	12	CD
cord-006702-ekf6mja9	803	5	patients	patient	NNS
cord-006702-ekf6mja9	803	6	(	(	-LRB-
cord-006702-ekf6mja9	803	7	f	f	NN
cord-006702-ekf6mja9	803	8	:	:	:
cord-006702-ekf6mja9	803	9	7	7	CD
cord-006702-ekf6mja9	803	10	,	,	,
cord-006702-ekf6mja9	803	11	median	median	JJ
cord-006702-ekf6mja9	803	12	age	age	NN
cord-006702-ekf6mja9	803	13	6.0	6.0	CD
cord-006702-ekf6mja9	803	14	yrs	yr	NNS
cord-006702-ekf6mja9	803	15	.	.	.
cord-006702-ekf6mja9	803	16	,	,	,
cord-006702-ekf6mja9	803	17	range	range	VBP
cord-006702-ekf6mja9	803	18	2.0	2.0	CD
cord-006702-ekf6mja9	803	19	to	to	IN
cord-006702-ekf6mja9	803	20	11.9	11.9	CD
cord-006702-ekf6mja9	803	21	)	)	-RRB-
cord-006702-ekf6mja9	803	22	showed	show	VBD
cord-006702-ekf6mja9	803	23	no	no	DT
cord-006702-ekf6mja9	803	24	renal	renal	JJ
cord-006702-ekf6mja9	803	25	impairment	impairment	NN
cord-006702-ekf6mja9	803	26	.	.	.
cord-006702-ekf6mja9	804	1	Sensitivity	sensitivity	NN
cord-006702-ekf6mja9	804	2	to	to	TO
cord-006702-ekf6mja9	804	3	detect	detect	VB
cord-006702-ekf6mja9	804	4	renal	renal	JJ
cord-006702-ekf6mja9	804	5	impairment	impairment	NN
cord-006702-ekf6mja9	804	6	using	use	VBG
cord-006702-ekf6mja9	804	7	the	the	DT
cord-006702-ekf6mja9	804	8	CKD	CKD	NNP
cord-006702-ekf6mja9	804	9	-	-	HYPH
cord-006702-ekf6mja9	804	10	pattern	pattern	NN
cord-006702-ekf6mja9	804	11	was	be	VBD
cord-006702-ekf6mja9	804	12	77	77	CD
cord-006702-ekf6mja9	804	13	%	%	NN
cord-006702-ekf6mja9	804	14	(	(	-LRB-
cord-006702-ekf6mja9	804	15	95	95	CD
cord-006702-ekf6mja9	804	16	%	%	NN
cord-006702-ekf6mja9	804	17	CI	CI	NNP
cord-006702-ekf6mja9	804	18	46	46	CD
cord-006702-ekf6mja9	804	19	-	-	SYM
cord-006702-ekf6mja9	804	20	95	95	CD
cord-006702-ekf6mja9	804	21	%	%	NN
cord-006702-ekf6mja9	804	22	)	)	-RRB-
cord-006702-ekf6mja9	804	23	and	and	CC
cord-006702-ekf6mja9	804	24	specificity	specificity	NN
cord-006702-ekf6mja9	804	25	was	be	VBD
cord-006702-ekf6mja9	804	26	92	92	CD
cord-006702-ekf6mja9	804	27	%	%	NN
cord-006702-ekf6mja9	804	28	(	(	-LRB-
cord-006702-ekf6mja9	804	29	95	95	CD
cord-006702-ekf6mja9	804	30	%	%	NN
cord-006702-ekf6mja9	804	31	CI	CI	NNP
cord-006702-ekf6mja9	804	32	62	62	CD
cord-006702-ekf6mja9	804	33	-	-	SYM
cord-006702-ekf6mja9	804	34	99	99	CD
cord-006702-ekf6mja9	804	35	%	%	NN
cord-006702-ekf6mja9	804	36	)	)	-RRB-
cord-006702-ekf6mja9	804	37	.	.	.
cord-006702-ekf6mja9	805	1	The	the	DT
cord-006702-ekf6mja9	805	2	area	area	NN
cord-006702-ekf6mja9	805	3	under	under	IN
cord-006702-ekf6mja9	805	4	the	the	DT
cord-006702-ekf6mja9	805	5	curve	curve	NN
cord-006702-ekf6mja9	805	6	was	be	VBD
cord-006702-ekf6mja9	805	7	0.80	0.80	CD
cord-006702-ekf6mja9	806	1	(	(	-LRB-
cord-006702-ekf6mja9	806	2	95	95	CD
cord-006702-ekf6mja9	806	3	%	%	NN
cord-006702-ekf6mja9	806	4	CI	CI	NNP
cord-006702-ekf6mja9	806	5	0.59	0.59	CD
cord-006702-ekf6mja9	806	6	-	-	HYPH
cord-006702-ekf6mja9	806	7	0.93	0.93	CD
cord-006702-ekf6mja9	806	8	;	;	:
cord-006702-ekf6mja9	806	9	p=0.012	p=0.012	NNP
cord-006702-ekf6mja9	806	10	)	)	-RRB-
cord-006702-ekf6mja9	806	11	.	.	.
cord-006702-ekf6mja9	807	1	Creatinine	creatinine	NN
cord-006702-ekf6mja9	807	2	based	base	VBN
cord-006702-ekf6mja9	807	3	estimation	estimation	NN
cord-006702-ekf6mja9	807	4	of	of	IN
cord-006702-ekf6mja9	807	5	GFR	GFR	NNP
cord-006702-ekf6mja9	807	6	detected	detect	VBD
cord-006702-ekf6mja9	807	7	only	only	RB
cord-006702-ekf6mja9	807	8	2/13	2/13	CD
cord-006702-ekf6mja9	807	9	patients	patient	NNS
cord-006702-ekf6mja9	807	10	(	(	-LRB-
cord-006702-ekf6mja9	807	11	15	15	CD
cord-006702-ekf6mja9	807	12	%	%	NN
cord-006702-ekf6mja9	807	13	)	)	-RRB-
cord-006702-ekf6mja9	807	14	correctly	correctly	RB
cord-006702-ekf6mja9	807	15	resulting	result	VBG
cord-006702-ekf6mja9	807	16	in	in	IN
cord-006702-ekf6mja9	807	17	a	a	DT
cord-006702-ekf6mja9	807	18	sensitivity	sensitivity	NN
cord-006702-ekf6mja9	807	19	of	of	IN
cord-006702-ekf6mja9	807	20	x	x	CD
cord-006702-ekf6mja9	807	21	%	%	NN
cord-006702-ekf6mja9	807	22	.	.	.
cord-006702-ekf6mja9	808	1	Using	use	VBG
cord-006702-ekf6mja9	808	2	multiple	multiple	JJ
cord-006702-ekf6mja9	808	3	testing	testing	NN
cord-006702-ekf6mja9	808	4	corrections	correction	NNS
cord-006702-ekf6mja9	808	5	,	,	,
cord-006702-ekf6mja9	808	6	20	20	CD
cord-006702-ekf6mja9	808	7	peptides	peptide	NNS
cord-006702-ekf6mja9	808	8	were	be	VBD
cord-006702-ekf6mja9	808	9	identified	identify	VBN
cord-006702-ekf6mja9	808	10	that	that	IN
cord-006702-ekf6mja9	808	11	significantly	significantly	RB
cord-006702-ekf6mja9	808	12	differentiated	differentiate	VBN
cord-006702-ekf6mja9	808	13	patients	patient	NNS
cord-006702-ekf6mja9	808	14	with	with	IN
cord-006702-ekf6mja9	808	15	renal	renal	JJ
cord-006702-ekf6mja9	808	16	impairment	impairment	NN
cord-006702-ekf6mja9	808	17	from	from	IN
cord-006702-ekf6mja9	808	18	those	those	DT
cord-006702-ekf6mja9	808	19	without	without	IN
cord-006702-ekf6mja9	808	20	.	.	.
cord-006702-ekf6mja9	809	1	Tandem	tandem	JJ
cord-006702-ekf6mja9	809	2	mass	mass	NN
cord-006702-ekf6mja9	809	3	spectrometry	spectrometry	NN
cord-006702-ekf6mja9	809	4	sequencing	sequencing	NN
cord-006702-ekf6mja9	809	5	revealed	reveal	VBD
cord-006702-ekf6mja9	809	6	10	10	CD
cord-006702-ekf6mja9	809	7	fragments	fragment	NNS
cord-006702-ekf6mja9	809	8	of	of	IN
cord-006702-ekf6mja9	809	9	collagen	collagen	NN
cord-006702-ekf6mja9	809	10	alpha-1(I	alpha-1(I	NNP
cord-006702-ekf6mja9	809	11	)	)	-RRB-
cord-006702-ekf6mja9	809	12	,	,	,
cord-006702-ekf6mja9	809	13	5	5	CD
cord-006702-ekf6mja9	809	14	of	of	IN
cord-006702-ekf6mja9	809	15	collagen	collagen	NN
cord-006702-ekf6mja9	809	16	alpha-1(III	alpha-1(III	NNP
cord-006702-ekf6mja9	809	17	)	)	-RRB-
cord-006702-ekf6mja9	809	18	and	and	CC
cord-006702-ekf6mja9	809	19	one	one	CD
cord-006702-ekf6mja9	809	20	fragment	fragment	NN
cord-006702-ekf6mja9	809	21	of	of	IN
cord-006702-ekf6mja9	809	22	collagen	collagen	NN
cord-006702-ekf6mja9	809	23	alpha-1	alpha-1	NNP
cord-006702-ekf6mja9	809	24	(	(	-LRB-
cord-006702-ekf6mja9	809	25	XVI	XVI	NNP
cord-006702-ekf6mja9	809	26	)	)	-RRB-
cord-006702-ekf6mja9	809	27	.	.	.
cord-006702-ekf6mja9	810	1	The	the	DT
cord-006702-ekf6mja9	810	2	urine	urine	NN
cord-006702-ekf6mja9	810	3	proteomics	proteomic	NNS
cord-006702-ekf6mja9	810	4	CKD	CKD	NNP
cord-006702-ekf6mja9	810	5	-	-	HYPH
cord-006702-ekf6mja9	810	6	pattern	pattern	NN
cord-006702-ekf6mja9	810	7	can	can	MD
cord-006702-ekf6mja9	810	8	reliably	reliably	RB
cord-006702-ekf6mja9	810	9	identify	identify	VB
cord-006702-ekf6mja9	810	10	children	child	NNS
cord-006702-ekf6mja9	810	11	with	with	IN
cord-006702-ekf6mja9	810	12	secondary	secondary	JJ
cord-006702-ekf6mja9	810	13	renal	renal	JJ
cord-006702-ekf6mja9	810	14	impairment	impairment	NN
cord-006702-ekf6mja9	810	15	after	after	IN
cord-006702-ekf6mja9	810	16	pOLT	polt	NN
cord-006702-ekf6mja9	810	17	with	with	IN
cord-006702-ekf6mja9	810	18	a	a	DT
cord-006702-ekf6mja9	810	19	significantly	significantly	RB
cord-006702-ekf6mja9	810	20	better	well	JJR
cord-006702-ekf6mja9	810	21	sensitivity	sensitivity	NN
cord-006702-ekf6mja9	810	22	as	as	IN
cord-006702-ekf6mja9	810	23	compared	compare	VBN
cord-006702-ekf6mja9	810	24	to	to	IN
cord-006702-ekf6mja9	810	25	standard	standard	JJ
cord-006702-ekf6mja9	810	26	creatinine	creatinine	NN
cord-006702-ekf6mja9	810	27	based	base	VBN
cord-006702-ekf6mja9	810	28	eGFR	egfr	NN
cord-006702-ekf6mja9	810	29	.	.	.
cord-006702-ekf6mja9	811	1	FP	FP	NNP
cord-006702-ekf6mja9	811	2	-	-	HYPH
cord-006702-ekf6mja9	811	3	S24	S24	NNP
cord-006702-ekf6mja9	811	4	-	-	HYPH
cord-006702-ekf6mja9	811	5	1	1	CD
cord-006702-ekf6mja9	812	1	Outcome	outcome	NN
cord-006702-ekf6mja9	812	2	and	and	CC
cord-006702-ekf6mja9	812	3	prognostic	prognostic	JJ
cord-006702-ekf6mja9	812	4	factors	factor	NNS
cord-006702-ekf6mja9	812	5	of	of	IN
cord-006702-ekf6mja9	812	6	nephropathic	nephropathic	NNP
cord-006702-ekf6mja9	812	7	cystinosis	cystinosis	NNP
cord-006702-ekf6mja9	812	8	:	:	:
cord-006702-ekf6mja9	812	9	data	datum	NNS
cord-006702-ekf6mja9	812	10	from	from	IN
cord-006702-ekf6mja9	812	11	the	the	DT
cord-006702-ekf6mja9	812	12	Eunefron	Eunefron	NNP
cord-006702-ekf6mja9	812	13	cohort	cohort	NN
cord-006702-ekf6mja9	812	14	F.	F.	NNP
cord-006702-ekf6mja9	812	15	emma	emma	NNP
cord-006702-ekf6mja9	812	16	(	(	-LRB-
cord-006702-ekf6mja9	812	17	1	1	CD
cord-006702-ekf6mja9	812	18	)	)	-RRB-
cord-006702-ekf6mja9	812	19	,	,	,
cord-006702-ekf6mja9	812	20	E.	E.	NNP
cord-006702-ekf6mja9	812	21	Levtchenko	Levtchenko	NNP
cord-006702-ekf6mja9	812	22	(	(	-LRB-
cord-006702-ekf6mja9	812	23	2	2	CD
cord-006702-ekf6mja9	812	24	)	)	-RRB-
cord-006702-ekf6mja9	812	25	,	,	,
cord-006702-ekf6mja9	812	26	G.	G.	NNP
cord-006702-ekf6mja9	812	27	Ariceta	Ariceta	NNP
cord-006702-ekf6mja9	812	28	(	(	-LRB-
cord-006702-ekf6mja9	812	29	3	3	CD
cord-006702-ekf6mja9	812	30	)	)	-RRB-
cord-006702-ekf6mja9	812	31	,	,	,
cord-006702-ekf6mja9	812	32	M.	M.	NNP
cord-006702-ekf6mja9	812	33	Greco	Greco	NNP
cord-006702-ekf6mja9	812	34	(	(	-LRB-
cord-006702-ekf6mja9	812	35	1	1	CD
cord-006702-ekf6mja9	812	36	)	)	-RRB-
cord-006702-ekf6mja9	812	37	,	,	,
cord-006702-ekf6mja9	812	38	W.	W.	NNP
cord-006702-ekf6mja9	812	39	Van'T	Van'T	NNP
cord-006702-ekf6mja9	812	40	Hoff	Hoff	NNP
cord-006702-ekf6mja9	812	41	(	(	-LRB-
cord-006702-ekf6mja9	812	42	4	4	CD
cord-006702-ekf6mja9	812	43	)	)	-RRB-
cord-006702-ekf6mja9	812	44	,	,	,
cord-006702-ekf6mja9	812	45	P.	P.	NNP
cord-006702-ekf6mja9	812	46	Niaudet	Niaudet	NNP
cord-006702-ekf6mja9	812	47	(	(	-LRB-
cord-006702-ekf6mja9	812	48	5	5	CD
cord-006702-ekf6mja9	812	49	.	.	.
cord-006702-ekf6mja9	813	1	After	after	IN
cord-006702-ekf6mja9	813	2	modelling	model	VBG
cord-006702-ekf6mja9	813	3	the	the	DT
cord-006702-ekf6mja9	813	4	HR	hr	NN
cord-006702-ekf6mja9	813	5	,	,	,
cord-006702-ekf6mja9	813	6	a	a	DT
cord-006702-ekf6mja9	813	7	nearly	nearly	RB
cord-006702-ekf6mja9	813	8	linear	linear	JJ
cord-006702-ekf6mja9	813	9	relationship	relationship	NN
cord-006702-ekf6mja9	813	10	was	be	VBD
cord-006702-ekf6mja9	813	11	observed	observe	VBN
cord-006702-ekf6mja9	813	12	with	with	IN
cord-006702-ekf6mja9	813	13	the	the	DT
cord-006702-ekf6mja9	813	14	age	age	NN
cord-006702-ekf6mja9	813	15	at	at	IN
cord-006702-ekf6mja9	813	16	which	which	WDT
cord-006702-ekf6mja9	813	17	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	813	18	was	be	VBD
cord-006702-ekf6mja9	813	19	started	start	VBN
cord-006702-ekf6mja9	813	20	from	from	IN
cord-006702-ekf6mja9	813	21	0.5	0.5	CD
cord-006702-ekf6mja9	813	22	to	to	TO
cord-006702-ekf6mja9	813	23	3.5	3.5	CD
cord-006702-ekf6mja9	813	24	years	year	NNS
cord-006702-ekf6mja9	813	25	and	and	CC
cord-006702-ekf6mja9	813	26	the	the	DT
cord-006702-ekf6mja9	813	27	risk	risk	NN
cord-006702-ekf6mja9	813	28	of	of	IN
cord-006702-ekf6mja9	813	29	dialysis	dialysis	NN
cord-006702-ekf6mja9	813	30	;	;	,
cord-006702-ekf6mja9	813	31	correcting	correct	VBG
cord-006702-ekf6mja9	813	32	for	for	IN
cord-006702-ekf6mja9	813	33	leucocyte	leucocyte	NNP
cord-006702-ekf6mja9	813	34	cysteine	cysteine	NN
cord-006702-ekf6mja9	813	35	levels	level	NNS
cord-006702-ekf6mja9	813	36	did	do	VBD
cord-006702-ekf6mja9	813	37	not	not	RB
cord-006702-ekf6mja9	813	38	change	change	VB
cord-006702-ekf6mja9	813	39	significantly	significantly	RB
cord-006702-ekf6mja9	813	40	this	this	DT
cord-006702-ekf6mja9	813	41	relationship	relationship	NN
cord-006702-ekf6mja9	813	42	.	.	.
cord-006702-ekf6mja9	814	1	Over	over	IN
cord-006702-ekf6mja9	814	2	the	the	DT
cord-006702-ekf6mja9	814	3	same	same	JJ
cord-006702-ekf6mja9	814	4	period	period	NN
cord-006702-ekf6mja9	814	5	of	of	IN
cord-006702-ekf6mja9	814	6	time	time	NN
cord-006702-ekf6mja9	814	7	,	,	,
cord-006702-ekf6mja9	814	8	linear	linear	JJ
cord-006702-ekf6mja9	814	9	growth	growth	NN
cord-006702-ekf6mja9	814	10	has	have	VBZ
cord-006702-ekf6mja9	814	11	improved	improve	VBN
cord-006702-ekf6mja9	814	12	.	.	.
cord-006702-ekf6mja9	815	1	Factors	factor	NNS
cord-006702-ekf6mja9	815	2	associated	associate	VBN
cord-006702-ekf6mja9	815	3	with	with	IN
cord-006702-ekf6mja9	815	4	improved	improved	JJ
cord-006702-ekf6mja9	815	5	outcome	outcome	NN
cord-006702-ekf6mja9	815	6	were	be	VBD
cord-006702-ekf6mja9	815	7	the	the	DT
cord-006702-ekf6mja9	815	8	use	use	NN
cord-006702-ekf6mja9	815	9	of	of	IN
cord-006702-ekf6mja9	815	10	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	815	11	,	,	,
cord-006702-ekf6mja9	815	12	of	of	IN
cord-006702-ekf6mja9	815	13	indomethacin	indomethacin	NN
cord-006702-ekf6mja9	815	14	and	and	CC
cord-006702-ekf6mja9	815	15	of	of	IN
cord-006702-ekf6mja9	815	16	growth	growth	NN
cord-006702-ekf6mja9	815	17	hormone	hormone	NN
cord-006702-ekf6mja9	815	18	.	.	.
cord-006702-ekf6mja9	816	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	816	2	:	:	:
cord-006702-ekf6mja9	817	1	This	this	DT
cord-006702-ekf6mja9	817	2	study	study	NN
cord-006702-ekf6mja9	817	3	represents	represent	VBZ
cord-006702-ekf6mja9	817	4	one	one	CD
cord-006702-ekf6mja9	817	5	of	of	IN
cord-006702-ekf6mja9	817	6	the	the	DT
cord-006702-ekf6mja9	817	7	largest	large	JJS
cord-006702-ekf6mja9	817	8	cohorts	cohort	NNS
cord-006702-ekf6mja9	817	9	of	of	IN
cord-006702-ekf6mja9	817	10	nephropathic	nephropathic	NNP
cord-006702-ekf6mja9	817	11	cystinosis	cystinosis	NNP
cord-006702-ekf6mja9	817	12	patients	patient	NNS
cord-006702-ekf6mja9	817	13	assembled	assemble	VBD
cord-006702-ekf6mja9	817	14	to	to	IN
cord-006702-ekf6mja9	817	15	date	date	NN
cord-006702-ekf6mja9	817	16	,	,	,
cord-006702-ekf6mja9	817	17	and	and	CC
cord-006702-ekf6mja9	817	18	shows	show	VBZ
cord-006702-ekf6mja9	817	19	a	a	DT
cord-006702-ekf6mja9	817	20	gain	gain	NN
cord-006702-ekf6mja9	817	21	of	of	IN
cord-006702-ekf6mja9	817	22	approximately	approximately	RB
cord-006702-ekf6mja9	817	23	6	6	CD
cord-006702-ekf6mja9	817	24	years	year	NNS
cord-006702-ekf6mja9	817	25	in	in	IN
cord-006702-ekf6mja9	817	26	the	the	DT
cord-006702-ekf6mja9	817	27	median	median	JJ
cord-006702-ekf6mja9	817	28	age	age	NN
cord-006702-ekf6mja9	817	29	to	to	TO
cord-006702-ekf6mja9	817	30	reach	reach	VB
cord-006702-ekf6mja9	817	31	dialysis	dialysis	NN
cord-006702-ekf6mja9	817	32	over	over	IN
cord-006702-ekf6mja9	817	33	a	a	DT
cord-006702-ekf6mja9	817	34	period	period	NN
cord-006702-ekf6mja9	817	35	of	of	IN
cord-006702-ekf6mja9	817	36	30	30	CD
cord-006702-ekf6mja9	817	37	years	year	NNS
cord-006702-ekf6mja9	817	38	.	.	.
cord-006702-ekf6mja9	818	1	Early	early	JJ
cord-006702-ekf6mja9	818	2	treatment	treatment	NN
cord-006702-ekf6mja9	818	3	with	with	IN
cord-006702-ekf6mja9	818	4	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	818	5	and	and	CC
cord-006702-ekf6mja9	818	6	the	the	DT
cord-006702-ekf6mja9	818	7	use	use	NN
cord-006702-ekf6mja9	818	8	of	of	IN
cord-006702-ekf6mja9	818	9	indomethacin	indomethacin	NN
cord-006702-ekf6mja9	818	10	influenced	influence	VBN
cord-006702-ekf6mja9	818	11	positively	positively	RB
cord-006702-ekf6mja9	818	12	renal	renal	JJ
cord-006702-ekf6mja9	818	13	outcome	outcome	NN
cord-006702-ekf6mja9	818	14	.	.	.
cord-006702-ekf6mja9	819	1	FP	FP	NNP
cord-006702-ekf6mja9	819	2	-	-	HYPH
cord-006702-ekf6mja9	819	3	S24	S24	NNP
cord-006702-ekf6mja9	819	4	-	-	HYPH
cord-006702-ekf6mja9	819	5	2	2	CD
cord-006702-ekf6mja9	820	1	A	a	DT
cord-006702-ekf6mja9	820	2	French	french	JJ
cord-006702-ekf6mja9	820	3	cohort	cohort	NN
cord-006702-ekf6mja9	820	4	of	of	IN
cord-006702-ekf6mja9	820	5	patients	patient	NNS
cord-006702-ekf6mja9	820	6	with	with	IN
cord-006702-ekf6mja9	820	7	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	820	8	:	:	:
cord-006702-ekf6mja9	821	1	Variability	variability	NN
cord-006702-ekf6mja9	821	2	in	in	IN
cord-006702-ekf6mja9	821	3	the	the	DT
cord-006702-ekf6mja9	821	4	compliance	compliance	NN
cord-006702-ekf6mja9	821	5	to	to	IN
cord-006702-ekf6mja9	821	6	two	two	CD
cord-006702-ekf6mja9	821	7	formulations	formulation	NNS
cord-006702-ekf6mja9	821	8	of	of	IN
cord-006702-ekf6mja9	821	9	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	821	10	,	,	,
cord-006702-ekf6mja9	821	11	use	use	NN
cord-006702-ekf6mja9	821	12	of	of	IN
cord-006702-ekf6mja9	821	13	electronic	electronic	JJ
cord-006702-ekf6mja9	821	14	monitoring	monitoring	NN
cord-006702-ekf6mja9	821	15	devices	device	NNS
cord-006702-ekf6mja9	821	16	S.	S.	NNP
cord-006702-ekf6mja9	821	17	Gaillard	Gaillard	NNP
cord-006702-ekf6mja9	821	18	(	(	-LRB-
cord-006702-ekf6mja9	821	19	1	1	CD
cord-006702-ekf6mja9	821	20	)	)	-RRB-
cord-006702-ekf6mja9	821	21	,	,	,
cord-006702-ekf6mja9	821	22	L.	L.	NNP
cord-006702-ekf6mja9	821	23	Roche	Roche	NNP
cord-006702-ekf6mja9	821	24	(	(	-LRB-
cord-006702-ekf6mja9	821	25	1	1	CD
cord-006702-ekf6mja9	821	26	)	)	-RRB-
cord-006702-ekf6mja9	821	27	,	,	,
cord-006702-ekf6mja9	821	28	B.	B.	NNP
cord-006702-ekf6mja9	821	29	Kassai	Kassai	NNP
cord-006702-ekf6mja9	821	30	(	(	-LRB-
cord-006702-ekf6mja9	821	31	1	1	CD
cord-006702-ekf6mja9	821	32	)	)	-RRB-
cord-006702-ekf6mja9	821	33	,	,	,
cord-006702-ekf6mja9	821	34	G.	G.	NNP
cord-006702-ekf6mja9	821	35	Deschenes	Deschenes	NNP
cord-006702-ekf6mja9	821	36	(	(	-LRB-
cord-006702-ekf6mja9	821	37	2	2	CD
cord-006702-ekf6mja9	821	38	)	)	-RRB-
cord-006702-ekf6mja9	821	39	,	,	,
cord-006702-ekf6mja9	821	40	D.	D.	NNP
cord-006702-ekf6mja9	821	41	Morin	Morin	NNP
cord-006702-ekf6mja9	821	42	(	(	-LRB-
cord-006702-ekf6mja9	821	43	3	3	CD
cord-006702-ekf6mja9	821	44	)	)	-RRB-
cord-006702-ekf6mja9	821	45	,	,	,
cord-006702-ekf6mja9	821	46	C.	C.	NNP
cord-006702-ekf6mja9	821	47	Acquaviva	Acquaviva	NNP
cord-006702-ekf6mja9	821	48	Bourdain	Bourdain	NNP
cord-006702-ekf6mja9	821	49	(	(	-LRB-
cord-006702-ekf6mja9	821	50	1	1	CD
cord-006702-ekf6mja9	821	51	)	)	-RRB-
cord-006702-ekf6mja9	821	52	,	,	,
cord-006702-ekf6mja9	821	53	A.	A.	NNP
cord-006702-ekf6mja9	821	54	Bertholet	Bertholet	NNP
cord-006702-ekf6mja9	821	55	-	-	HYPH
cord-006702-ekf6mja9	821	56	Thomas	Thomas	NNP
cord-006702-ekf6mja9	821	57	(	(	-LRB-
cord-006702-ekf6mja9	821	58	1	1	CD
cord-006702-ekf6mja9	821	59	)	)	-RRB-
cord-006702-ekf6mja9	821	60	,	,	,
cord-006702-ekf6mja9	821	61	P.	P.	NNP
cord-006702-ekf6mja9	821	62	Cochat	Cochat	NNP
cord-006702-ekf6mja9	821	63	(	(	-LRB-
cord-006702-ekf6mja9	821	64	1	1	CD
cord-006702-ekf6mja9	821	65	)	)	-RRB-
cord-006702-ekf6mja9	821	66	(	(	-LRB-
cord-006702-ekf6mja9	821	67	1	1	LS
cord-006702-ekf6mja9	821	68	)	)	-RRB-
cord-006702-ekf6mja9	821	69	Hospices	Hospices	NNPS
cord-006702-ekf6mja9	821	70	Civils	Civils	NNP
cord-006702-ekf6mja9	821	71	de	de	NNP
cord-006702-ekf6mja9	821	72	Lyon	Lyon	NNP
cord-006702-ekf6mja9	821	73	-Chu	-Chu	:
cord-006702-ekf6mja9	821	74	Lyon	Lyon	NNP
cord-006702-ekf6mja9	821	75	,	,	,
cord-006702-ekf6mja9	821	76	Lyon	Lyon	NNP
cord-006702-ekf6mja9	821	77	,	,	,
cord-006702-ekf6mja9	821	78	France	France	NNP
cord-006702-ekf6mja9	821	79	;	;	:
cord-006702-ekf6mja9	822	1	(	(	-LRB-
cord-006702-ekf6mja9	822	2	2	2	LS
cord-006702-ekf6mja9	822	3	)	)	-RRB-
cord-006702-ekf6mja9	822	4	APHP	APHP	NNP
cord-006702-ekf6mja9	823	1	-Hôpital	-Hôpital	NNP
cord-006702-ekf6mja9	824	1	Robert	Robert	NNP
cord-006702-ekf6mja9	824	2	Debré	Debré	NNP
cord-006702-ekf6mja9	824	3	,	,	,
cord-006702-ekf6mja9	824	4	Paris	Paris	NNP
cord-006702-ekf6mja9	824	5	,	,	,
cord-006702-ekf6mja9	824	6	France	France	NNP
cord-006702-ekf6mja9	824	7	;	;	:
cord-006702-ekf6mja9	824	8	(	(	-LRB-
cord-006702-ekf6mja9	824	9	3	3	LS
cord-006702-ekf6mja9	824	10	)	)	-RRB-
cord-006702-ekf6mja9	825	1	Chu	Chu	NNP
cord-006702-ekf6mja9	825	2	Montpellier	Montpellier	NNP
cord-006702-ekf6mja9	825	3	,	,	,
cord-006702-ekf6mja9	825	4	Montpellier	Montpellier	NNP
cord-006702-ekf6mja9	825	5	,	,	,
cord-006702-ekf6mja9	826	1	France	France	NNP
cord-006702-ekf6mja9	826	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	827	1	:	:	:
cord-006702-ekf6mja9	827	2	Cystinosis	Cystinosis	NNP
cord-006702-ekf6mja9	827	3	is	be	VBZ
cord-006702-ekf6mja9	827	4	an	an	DT
cord-006702-ekf6mja9	827	5	inherited	inherit	VBN
cord-006702-ekf6mja9	827	6	autosomal	autosomal	JJ
cord-006702-ekf6mja9	827	7	recessive	recessive	JJ
cord-006702-ekf6mja9	827	8	disease	disease	NN
cord-006702-ekf6mja9	827	9	.	.	.
cord-006702-ekf6mja9	828	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	828	2	objectives	objective	NNS
cord-006702-ekf6mja9	828	3	are	be	VBP
cord-006702-ekf6mja9	828	4	(	(	-LRB-
cord-006702-ekf6mja9	828	5	i	i	NN
cord-006702-ekf6mja9	828	6	)	)	-RRB-
cord-006702-ekf6mja9	828	7	to	to	TO
cord-006702-ekf6mja9	828	8	describe	describe	VB
cord-006702-ekf6mja9	828	9	the	the	DT
cord-006702-ekf6mja9	828	10	profiles	profile	NNS
cord-006702-ekf6mja9	828	11	of	of	IN
cord-006702-ekf6mja9	828	12	compliance	compliance	NN
cord-006702-ekf6mja9	828	13	to	to	IN
cord-006702-ekf6mja9	828	14	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	828	15	treatment	treatment	NN
cord-006702-ekf6mja9	828	16	and	and	CC
cord-006702-ekf6mja9	828	17	White	White	NNP
cord-006702-ekf6mja9	828	18	Blood	Blood	NNP
cord-006702-ekf6mja9	828	19	Cell	Cell	NNP
cord-006702-ekf6mja9	828	20	(	(	-LRB-
cord-006702-ekf6mja9	828	21	WBC	WBC	NNP
cord-006702-ekf6mja9	828	22	)	)	-RRB-
cord-006702-ekf6mja9	828	23	cystine	cystine	NN
cord-006702-ekf6mja9	828	24	levels	level	NNS
cord-006702-ekf6mja9	828	25	in	in	IN
cord-006702-ekf6mja9	828	26	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	828	27	patients	patient	NNS
cord-006702-ekf6mja9	828	28	followed	follow	VBD
cord-006702-ekf6mja9	828	29	up	up	RP
cord-006702-ekf6mja9	828	30	for	for	IN
cord-006702-ekf6mja9	828	31	one	one	CD
cord-006702-ekf6mja9	828	32	year	year	NN
cord-006702-ekf6mja9	828	33	;	;	,
cord-006702-ekf6mja9	828	34	and	and	CC
cord-006702-ekf6mja9	828	35	(	(	-LRB-
cord-006702-ekf6mja9	828	36	ii	ii	NN
cord-006702-ekf6mja9	828	37	)	)	-RRB-
cord-006702-ekf6mja9	828	38	to	to	TO
cord-006702-ekf6mja9	828	39	explore	explore	VB
cord-006702-ekf6mja9	828	40	the	the	DT
cord-006702-ekf6mja9	828	41	differences	difference	NNS
cord-006702-ekf6mja9	828	42	of	of	IN
cord-006702-ekf6mja9	828	43	compliance	compliance	NN
cord-006702-ekf6mja9	828	44	under	under	IN
cord-006702-ekf6mja9	828	45	delayedrelease	delayedrelease	NNP
cord-006702-ekf6mja9	828	46	or	or	CC
cord-006702-ekf6mja9	828	47	short	short	RB
cord-006702-ekf6mja9	828	48	-	-	HYPH
cord-006702-ekf6mja9	828	49	acting	act	VBG
cord-006702-ekf6mja9	828	50	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	828	51	.	.	.
cord-006702-ekf6mja9	829	1	Methods	method	NNS
cord-006702-ekf6mja9	829	2	:	:	:
cord-006702-ekf6mja9	829	3	CrYStobs	CrYStobs	NNP
cord-006702-ekf6mja9	829	4	is	be	VBZ
cord-006702-ekf6mja9	829	5	a	a	DT
cord-006702-ekf6mja9	829	6	French	french	JJ
cord-006702-ekf6mja9	829	7	cohort	cohort	NN
cord-006702-ekf6mja9	829	8	of	of	IN
cord-006702-ekf6mja9	829	9	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	829	10	patients	patient	NNS
cord-006702-ekf6mja9	829	11	.	.	.
cord-006702-ekf6mja9	830	1	Thirty	thirty	CD
cord-006702-ekf6mja9	830	2	patients	patient	NNS
cord-006702-ekf6mja9	830	3	are	be	VBP
cord-006702-ekf6mja9	830	4	expected	expect	VBN
cord-006702-ekf6mja9	830	5	.	.	.
cord-006702-ekf6mja9	831	1	All	all	DT
cord-006702-ekf6mja9	831	2	subjects	subject	NNS
cord-006702-ekf6mja9	831	3	receive	receive	VBP
cord-006702-ekf6mja9	831	4	oral	oral	JJ
cord-006702-ekf6mja9	831	5	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	831	6	.	.	.
cord-006702-ekf6mja9	832	1	Four	four	CD
cord-006702-ekf6mja9	832	2	patients	patient	NNS
cord-006702-ekf6mja9	832	3	have	have	VBP
cord-006702-ekf6mja9	832	4	received	receive	VBN
cord-006702-ekf6mja9	832	5	short	short	JJ
cord-006702-ekf6mja9	832	6	acting	act	VBG
cord-006702-ekf6mja9	832	7	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	832	8	then	then	RB
cord-006702-ekf6mja9	832	9	delayed	delay	VBN
cord-006702-ekf6mja9	832	10	-	-	HYPH
cord-006702-ekf6mja9	832	11	release	release	NN
cord-006702-ekf6mja9	832	12	formulation	formulation	NN
cord-006702-ekf6mja9	832	13	.	.	.
cord-006702-ekf6mja9	833	1	A	a	DT
cord-006702-ekf6mja9	833	2	descriptive	descriptive	JJ
cord-006702-ekf6mja9	833	3	analysis	analysis	NN
cord-006702-ekf6mja9	833	4	is	be	VBZ
cord-006702-ekf6mja9	833	5	performed	perform	VBN
cord-006702-ekf6mja9	833	6	on	on	IN
cord-006702-ekf6mja9	833	7	subjects	subject	NNS
cord-006702-ekf6mja9	833	8	followed	follow	VBN
cord-006702-ekf6mja9	833	9	-	-	HYPH
cord-006702-ekf6mja9	833	10	up	up	NN
cord-006702-ekf6mja9	833	11	for	for	IN
cord-006702-ekf6mja9	833	12	one	one	CD
cord-006702-ekf6mja9	833	13	year	year	NN
cord-006702-ekf6mja9	833	14	.	.	.
cord-006702-ekf6mja9	834	1	Compliance	compliance	NN
cord-006702-ekf6mja9	834	2	is	be	VBZ
cord-006702-ekf6mja9	834	3	described	describe	VBN
cord-006702-ekf6mja9	834	4	as	as	IN
cord-006702-ekf6mja9	834	5	a	a	DT
cord-006702-ekf6mja9	834	6	continuous	continuous	JJ
cord-006702-ekf6mja9	834	7	variable	variable	NN
cord-006702-ekf6mja9	834	8	,	,	,
cord-006702-ekf6mja9	834	9	using	use	VBG
cord-006702-ekf6mja9	834	10	an	an	DT
cord-006702-ekf6mja9	834	11	electronic	electronic	JJ
cord-006702-ekf6mja9	834	12	monitoring	monitoring	NN
cord-006702-ekf6mja9	834	13	system	system	NN
cord-006702-ekf6mja9	834	14	.	.	.
cord-006702-ekf6mja9	835	1	Levels	level	NNS
cord-006702-ekf6mja9	835	2	of	of	IN
cord-006702-ekf6mja9	835	3	compliance	compliance	NN
cord-006702-ekf6mja9	835	4	(	(	-LRB-
cord-006702-ekf6mja9	835	5	0	0	CD
cord-006702-ekf6mja9	835	6	:	:	:
cord-006702-ekf6mja9	835	7	bad	bad	JJ
cord-006702-ekf6mja9	835	8	compliance	compliance	NN
cord-006702-ekf6mja9	835	9	;	;	:
cord-006702-ekf6mja9	835	10	1	1	LS
cord-006702-ekf6mja9	835	11	:	:	:
cord-006702-ekf6mja9	835	12	correct	correct	JJ
cord-006702-ekf6mja9	835	13	compliance	compliance	NN
cord-006702-ekf6mja9	835	14	and	and	CC
cord-006702-ekf6mja9	835	15	2	2	CD
cord-006702-ekf6mja9	835	16	:	:	:
cord-006702-ekf6mja9	835	17	good	good	JJ
cord-006702-ekf6mja9	835	18	compliance	compliance	NN
cord-006702-ekf6mja9	835	19	)	)	-RRB-
cord-006702-ekf6mja9	835	20	are	be	VBP
cord-006702-ekf6mja9	835	21	computed	compute	VBN
cord-006702-ekf6mja9	835	22	individually	individually	RB
cord-006702-ekf6mja9	835	23	for	for	IN
cord-006702-ekf6mja9	835	24	the	the	DT
cord-006702-ekf6mja9	835	25	17	17	CD
cord-006702-ekf6mja9	835	26	patients	patient	NNS
cord-006702-ekf6mja9	835	27	:	:	:
cord-006702-ekf6mja9	835	28	i	i	LS
cord-006702-ekf6mja9	835	29	)	)	-RRB-
cord-006702-ekf6mja9	835	30	monthly	monthly	NNP
cord-006702-ekf6mja9	835	31	;	;	:
cord-006702-ekf6mja9	835	32	ii	ii	LS
cord-006702-ekf6mja9	835	33	)	)	-RRB-
cord-006702-ekf6mja9	835	34	quarterly	quarterly	NNP
cord-006702-ekf6mja9	835	35	;	;	:
cord-006702-ekf6mja9	835	36	and	and	CC
cord-006702-ekf6mja9	835	37	iii	iii	LS
cord-006702-ekf6mja9	835	38	)	)	-RRB-
cord-006702-ekf6mja9	836	1	overall	overall	RB
cord-006702-ekf6mja9	836	2	during	during	IN
cord-006702-ekf6mja9	836	3	the	the	DT
cord-006702-ekf6mja9	836	4	first	first	JJ
cord-006702-ekf6mja9	836	5	year	year	NN
cord-006702-ekf6mja9	836	6	.	.	.
cord-006702-ekf6mja9	837	1	Mean	mean	JJ
cord-006702-ekf6mja9	837	2	compliance	compliance	NN
cord-006702-ekf6mja9	837	3	scores	score	NNS
cord-006702-ekf6mja9	837	4	are	be	VBP
cord-006702-ekf6mja9	837	5	summarized	summarize	VBN
cord-006702-ekf6mja9	837	6	quarterly	quarterly	RB
cord-006702-ekf6mja9	837	7	as	as	IN
cord-006702-ekf6mja9	837	8	median	median	NN
cord-006702-ekf6mja9	837	9	,	,	,
cord-006702-ekf6mja9	837	10	25	25	CD
cord-006702-ekf6mja9	837	11	and	and	CC
cord-006702-ekf6mja9	837	12	75	75	CD
cord-006702-ekf6mja9	837	13	percentiles	percentile	NNS
cord-006702-ekf6mja9	837	14	,	,	,
cord-006702-ekf6mja9	837	15	minimum	minimum	NN
cord-006702-ekf6mja9	837	16	and	and	CC
cord-006702-ekf6mja9	837	17	maximum	maximum	NN
cord-006702-ekf6mja9	837	18	observed	observe	VBN
cord-006702-ekf6mja9	837	19	.	.	.
cord-006702-ekf6mja9	838	1	The	the	DT
cord-006702-ekf6mja9	838	2	"	"	``
cord-006702-ekf6mja9	838	3	number	number	NN
cord-006702-ekf6mja9	838	4	of	of	IN
cord-006702-ekf6mja9	838	5	hours	hour	NNS
cord-006702-ekf6mja9	838	6	covered	cover	VBN
cord-006702-ekf6mja9	838	7	by	by	IN
cord-006702-ekf6mja9	838	8	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	838	9	"	"	''
cord-006702-ekf6mja9	838	10	is	be	VBZ
cord-006702-ekf6mja9	838	11	generated	generate	VBN
cord-006702-ekf6mja9	838	12	per	per	IN
cord-006702-ekf6mja9	838	13	day	day	NN
cord-006702-ekf6mja9	838	14	.	.	.
cord-006702-ekf6mja9	839	1	Patients	patient	NNS
cord-006702-ekf6mja9	839	2	'	'	POS
cord-006702-ekf6mja9	839	3	self	self	NN
cord-006702-ekf6mja9	839	4	-	-	HYPH
cord-006702-ekf6mja9	839	5	evaluations	evaluation	NNS
cord-006702-ekf6mja9	839	6	of	of	IN
cord-006702-ekf6mja9	839	7	compliance	compliance	NN
cord-006702-ekf6mja9	839	8	are	be	VBP
cord-006702-ekf6mja9	839	9	available	available	JJ
cord-006702-ekf6mja9	839	10	at	at	IN
cord-006702-ekf6mja9	839	11	each	each	DT
cord-006702-ekf6mja9	839	12	visit	visit	NN
cord-006702-ekf6mja9	839	13	.	.	.
cord-006702-ekf6mja9	840	1	Results	result	NNS
cord-006702-ekf6mja9	840	2	:	:	:
cord-006702-ekf6mja9	841	1	Seventeen	seventeen	CD
cord-006702-ekf6mja9	841	2	patients	patient	NNS
cord-006702-ekf6mja9	841	3	(	(	-LRB-
cord-006702-ekf6mja9	841	4	mean	mean	VB
cord-006702-ekf6mja9	841	5	age	age	NN
cord-006702-ekf6mja9	841	6	:	:	:
cord-006702-ekf6mja9	841	7	17.5	17.5	CD
cord-006702-ekf6mja9	841	8	years	year	NNS
cord-006702-ekf6mja9	841	9	;	;	:
cord-006702-ekf6mja9	841	10	58	58	CD
cord-006702-ekf6mja9	841	11	%	%	NN
cord-006702-ekf6mja9	841	12	female	female	NN
cord-006702-ekf6mja9	841	13	)	)	-RRB-
cord-006702-ekf6mja9	841	14	were	be	VBD
cord-006702-ekf6mja9	841	15	analyzed	analyze	VBN
cord-006702-ekf6mja9	841	16	.	.	.
cord-006702-ekf6mja9	842	1	Seven	seven	CD
cord-006702-ekf6mja9	842	2	patients	patient	NNS
cord-006702-ekf6mja9	842	3	were	be	VBD
cord-006702-ekf6mja9	842	4	transplanted	transplant	VBN
cord-006702-ekf6mja9	842	5	and	and	CC
cord-006702-ekf6mja9	842	6	2	2	CD
cord-006702-ekf6mja9	842	7	under	under	IN
cord-006702-ekf6mja9	842	8	dialysis	dialysis	NN
cord-006702-ekf6mja9	842	9	.	.	.
cord-006702-ekf6mja9	843	1	eGFR	eGFR	NNP
cord-006702-ekf6mja9	843	2	remained	remain	VBD
cord-006702-ekf6mja9	843	3	stable	stable	JJ
cord-006702-ekf6mja9	843	4	over	over	IN
cord-006702-ekf6mja9	843	5	time	time	NN
cord-006702-ekf6mja9	843	6	.	.	.
cord-006702-ekf6mja9	844	1	While	while	IN
cord-006702-ekf6mja9	844	2	WBC	WBC	NNP
cord-006702-ekf6mja9	844	3	cystine	cystine	NN
cord-006702-ekf6mja9	844	4	levels	level	NNS
cord-006702-ekf6mja9	844	5	remained	remain	VBD
cord-006702-ekf6mja9	844	6	under	under	IN
cord-006702-ekf6mja9	844	7	1	1	CD
cord-006702-ekf6mja9	844	8	μmol/	μmol/	NN
cord-006702-ekf6mja9	844	9	½	½	CD
cord-006702-ekf6mja9	844	10	cystine	cystine	NN
cord-006702-ekf6mja9	844	11	/	/	SYM
cord-006702-ekf6mja9	844	12	g	g	NN
cord-006702-ekf6mja9	844	13	protein	protein	NN
cord-006702-ekf6mja9	844	14	,	,	,
cord-006702-ekf6mja9	844	15	there	there	EX
cord-006702-ekf6mja9	844	16	was	be	VBD
cord-006702-ekf6mja9	844	17	a	a	DT
cord-006702-ekf6mja9	844	18	great	great	JJ
cord-006702-ekf6mja9	844	19	variability	variability	NN
cord-006702-ekf6mja9	844	20	among	among	IN
cord-006702-ekf6mja9	844	21	patients	patient	NNS
cord-006702-ekf6mja9	844	22	and	and	CC
cord-006702-ekf6mja9	844	23	over	over	IN
cord-006702-ekf6mja9	844	24	time	time	NN
cord-006702-ekf6mja9	844	25	in	in	IN
cord-006702-ekf6mja9	844	26	the	the	DT
cord-006702-ekf6mja9	844	27	mean	mean	JJ
cord-006702-ekf6mja9	844	28	quarterly	quarterly	JJ
cord-006702-ekf6mja9	844	29	compliance	compliance	NN
cord-006702-ekf6mja9	844	30	score	score	NN
cord-006702-ekf6mja9	844	31	(	(	-LRB-
cord-006702-ekf6mja9	844	32	Median	median	NN
cord-006702-ekf6mja9	844	33	:	:	:
cord-006702-ekf6mja9	844	34	1.9	1.9	CD
cord-006702-ekf6mja9	844	35	at	at	IN
cord-006702-ekf6mja9	844	36	inclusion	inclusion	NN
cord-006702-ekf6mja9	844	37	-1.6	-1.6	NNS
cord-006702-ekf6mja9	844	38	at	at	IN
cord-006702-ekf6mja9	844	39	M12	M12	NNP
cord-006702-ekf6mja9	844	40	,	,	,
cord-006702-ekf6mja9	844	41	min	min	NN
cord-006702-ekf6mja9	844	42	=	=	SYM
cord-006702-ekf6mja9	844	43	0.05	0.05	CD
cord-006702-ekf6mja9	844	44	-max=2	-max=2	NN
cord-006702-ekf6mja9	844	45	)	)	-RRB-
cord-006702-ekf6mja9	844	46	.	.	.
cord-006702-ekf6mja9	845	1	However	however	RB
cord-006702-ekf6mja9	845	2	,	,	,
cord-006702-ekf6mja9	845	3	subjects	subject	NNS
cord-006702-ekf6mja9	845	4	were	be	VBD
cord-006702-ekf6mja9	845	5	globally	globally	RB
cord-006702-ekf6mja9	845	6	well	well	RB
cord-006702-ekf6mja9	845	7	covered	cover	VBN
cord-006702-ekf6mja9	845	8	by	by	IN
cord-006702-ekf6mja9	845	9	their	-PRON-	PRP$
cord-006702-ekf6mja9	845	10	study	study	NN
cord-006702-ekf6mja9	845	11	treatment	treatment	NN
cord-006702-ekf6mja9	845	12	:	:	:
cord-006702-ekf6mja9	845	13	22	22	CD
cord-006702-ekf6mja9	845	14	to	to	TO
cord-006702-ekf6mja9	845	15	23	23	CD
cord-006702-ekf6mja9	845	16	hours	hour	NNS
cord-006702-ekf6mja9	845	17	daily	daily	JJ
cord-006702-ekf6mja9	845	18	coverage	coverage	NN
cord-006702-ekf6mja9	845	19	.	.	.
cord-006702-ekf6mja9	846	1	The	the	DT
cord-006702-ekf6mja9	846	2	compliance	compliance	NN
cord-006702-ekf6mja9	846	3	scores	score	NNS
cord-006702-ekf6mja9	846	4	seemed	seem	VBD
cord-006702-ekf6mja9	846	5	improved	improve	VBN
cord-006702-ekf6mja9	846	6	under	under	IN
cord-006702-ekf6mja9	846	7	delayed	delay	VBN
cord-006702-ekf6mja9	846	8	-	-	HYPH
cord-006702-ekf6mja9	846	9	release	release	NN
cord-006702-ekf6mja9	846	10	formulation	formulation	NN
cord-006702-ekf6mja9	846	11	.	.	.
cord-006702-ekf6mja9	847	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	847	2	:	:	:
cord-006702-ekf6mja9	848	1	CrYSTobs	CrYSTobs	NNP
cord-006702-ekf6mja9	848	2	is	be	VBZ
cord-006702-ekf6mja9	848	3	the	the	DT
cord-006702-ekf6mja9	848	4	first	first	JJ
cord-006702-ekf6mja9	848	5	study	study	NN
cord-006702-ekf6mja9	848	6	measuring	measure	VBG
cord-006702-ekf6mja9	848	7	objectively	objectively	RB
cord-006702-ekf6mja9	848	8	compliance	compliance	NN
cord-006702-ekf6mja9	848	9	to	to	IN
cord-006702-ekf6mja9	848	10	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	848	11	in	in	IN
cord-006702-ekf6mja9	848	12	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	848	13	patients	patient	NNS
cord-006702-ekf6mja9	848	14	.	.	.
cord-006702-ekf6mja9	849	1	We	-PRON-	PRP
cord-006702-ekf6mja9	849	2	observed	observe	VBD
cord-006702-ekf6mja9	849	3	a	a	DT
cord-006702-ekf6mja9	849	4	great	great	JJ
cord-006702-ekf6mja9	849	5	variability	variability	NN
cord-006702-ekf6mja9	849	6	among	among	IN
cord-006702-ekf6mja9	849	7	compliance	compliance	NN
cord-006702-ekf6mja9	849	8	profiles	profile	NNS
cord-006702-ekf6mja9	849	9	,	,	,
cord-006702-ekf6mja9	849	10	and	and	CC
cord-006702-ekf6mja9	849	11	a	a	DT
cord-006702-ekf6mja9	849	12	trend	trend	NN
cord-006702-ekf6mja9	849	13	towards	towards	IN
cord-006702-ekf6mja9	849	14	improvement	improvement	NN
cord-006702-ekf6mja9	849	15	in	in	IN
cord-006702-ekf6mja9	849	16	compliance	compliance	NN
cord-006702-ekf6mja9	849	17	under	under	IN
cord-006702-ekf6mja9	849	18	delayed	delay	VBN
cord-006702-ekf6mja9	849	19	-	-	HYPH
cord-006702-ekf6mja9	849	20	release	release	NN
cord-006702-ekf6mja9	849	21	cysteamine	cysteamine	NN
cord-006702-ekf6mja9	849	22	.	.	.
cord-006702-ekf6mja9	850	1	Objectives	objective	NNS
cord-006702-ekf6mja9	850	2	:	:	:
cord-006702-ekf6mja9	850	3	Cystinosis	Cystinosis	NNP
cord-006702-ekf6mja9	850	4	is	be	VBZ
cord-006702-ekf6mja9	850	5	a	a	DT
cord-006702-ekf6mja9	850	6	lysosomal	lysosomal	JJ
cord-006702-ekf6mja9	850	7	storage	storage	NN
cord-006702-ekf6mja9	850	8	disorder	disorder	NN
cord-006702-ekf6mja9	850	9	characterized	characterize	VBN
cord-006702-ekf6mja9	850	10	by	by	IN
cord-006702-ekf6mja9	850	11	accumulation	accumulation	NN
cord-006702-ekf6mja9	850	12	and	and	CC
cord-006702-ekf6mja9	850	13	crystallization	crystallization	NN
cord-006702-ekf6mja9	850	14	of	of	IN
cord-006702-ekf6mja9	850	15	cystine	cystine	NN
cord-006702-ekf6mja9	850	16	in	in	IN
cord-006702-ekf6mja9	850	17	different	different	JJ
cord-006702-ekf6mja9	850	18	cell	cell	NN
cord-006702-ekf6mja9	850	19	types	type	NNS
cord-006702-ekf6mja9	850	20	.	.	.
cord-006702-ekf6mja9	851	1	If	if	IN
cord-006702-ekf6mja9	851	2	not	not	RB
cord-006702-ekf6mja9	851	3	treated	treat	VBN
cord-006702-ekf6mja9	851	4	,	,	,
cord-006702-ekf6mja9	851	5	renal	renal	JJ
cord-006702-ekf6mja9	851	6	failure	failure	NN
cord-006702-ekf6mja9	851	7	invariably	invariably	RB
cord-006702-ekf6mja9	851	8	develops	develop	VBZ
cord-006702-ekf6mja9	851	9	within	within	IN
cord-006702-ekf6mja9	851	10	the	the	DT
cord-006702-ekf6mja9	851	11	first	first	JJ
cord-006702-ekf6mja9	851	12	decade	decade	NN
cord-006702-ekf6mja9	851	13	of	of	IN
cord-006702-ekf6mja9	851	14	life	life	NN
cord-006702-ekf6mja9	851	15	.	.	.
cord-006702-ekf6mja9	852	1	We	-PRON-	PRP
cord-006702-ekf6mja9	852	2	have	have	VBP
cord-006702-ekf6mja9	852	3	shown	show	VBN
cord-006702-ekf6mja9	852	4	excessive	excessive	JJ
cord-006702-ekf6mja9	852	5	number	number	NN
cord-006702-ekf6mja9	852	6	of	of	IN
cord-006702-ekf6mja9	852	7	podocytes	podocyte	NNS
cord-006702-ekf6mja9	852	8	and	and	CC
cord-006702-ekf6mja9	852	9	proximal	proximal	JJ
cord-006702-ekf6mja9	852	10	tubular	tubular	JJ
cord-006702-ekf6mja9	852	11	cells	cell	NNS
cord-006702-ekf6mja9	852	12	in	in	IN
cord-006702-ekf6mja9	852	13	urine	urine	NN
cord-006702-ekf6mja9	852	14	of	of	IN
cord-006702-ekf6mja9	852	15	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	852	16	patients	patient	NNS
cord-006702-ekf6mja9	852	17	.	.	.
cord-006702-ekf6mja9	853	1	Now	now	RB
cord-006702-ekf6mja9	853	2	,	,	,
cord-006702-ekf6mja9	853	3	we	-PRON-	PRP
cord-006702-ekf6mja9	853	4	hypothesized	hypothesize	VBD
cord-006702-ekf6mja9	853	5	that	that	IN
cord-006702-ekf6mja9	853	6	in	in	IN
cord-006702-ekf6mja9	853	7	compensation	compensation	NN
cord-006702-ekf6mja9	853	8	for	for	IN
cord-006702-ekf6mja9	853	9	cell	cell	NN
cord-006702-ekf6mja9	853	10	loss	loss	NN
cord-006702-ekf6mja9	853	11	,	,	,
cord-006702-ekf6mja9	853	12	ongoing	ongoing	JJ
cord-006702-ekf6mja9	853	13	regeneration	regeneration	NN
cord-006702-ekf6mja9	853	14	might	may	MD
cord-006702-ekf6mja9	853	15	happen	happen	VB
cord-006702-ekf6mja9	853	16	,	,	,
cord-006702-ekf6mja9	853	17	and	and	CC
cord-006702-ekf6mja9	853	18	it	-PRON-	PRP
cord-006702-ekf6mja9	853	19	could	could	MD
cord-006702-ekf6mja9	853	20	be	be	VB
cord-006702-ekf6mja9	853	21	reflected	reflect	VBN
cord-006702-ekf6mja9	853	22	by	by	IN
cord-006702-ekf6mja9	853	23	the	the	DT
cord-006702-ekf6mja9	853	24	presence	presence	NN
cord-006702-ekf6mja9	853	25	of	of	IN
cord-006702-ekf6mja9	853	26	kidney	kidney	NN
cord-006702-ekf6mja9	853	27	progenitor	progenitor	NN
cord-006702-ekf6mja9	853	28	cells	cell	NNS
cord-006702-ekf6mja9	853	29	in	in	IN
cord-006702-ekf6mja9	853	30	urine	urine	NN
cord-006702-ekf6mja9	853	31	of	of	IN
cord-006702-ekf6mja9	853	32	the	the	DT
cord-006702-ekf6mja9	853	33	patients	patient	NNS
cord-006702-ekf6mja9	853	34	.	.	.
cord-006702-ekf6mja9	854	1	Methods	method	NNS
cord-006702-ekf6mja9	854	2	:	:	:
cord-006702-ekf6mja9	855	1	We	-PRON-	PRP
cord-006702-ekf6mja9	855	2	quantified	quantify	VBD
cord-006702-ekf6mja9	855	3	the	the	DT
cord-006702-ekf6mja9	855	4	number	number	NN
cord-006702-ekf6mja9	855	5	of	of	IN
cord-006702-ekf6mja9	855	6	kidney	kidney	NN
cord-006702-ekf6mja9	855	7	progenitor	progenitor	NN
cord-006702-ekf6mja9	855	8	cells	cell	NNS
cord-006702-ekf6mja9	855	9	in	in	IN
cord-006702-ekf6mja9	855	10	urine	urine	NN
cord-006702-ekf6mja9	855	11	using	use	VBG
cord-006702-ekf6mja9	855	12	qPCR	qPCR	NNP
cord-006702-ekf6mja9	855	13	analysis	analysis	NN
cord-006702-ekf6mja9	855	14	of	of	IN
cord-006702-ekf6mja9	855	15	mRNA	mRNA	NNP
cord-006702-ekf6mja9	855	16	extracted	extract	VBN
cord-006702-ekf6mja9	855	17	of	of	IN
cord-006702-ekf6mja9	855	18	urine	urine	NN
cord-006702-ekf6mja9	855	19	samples	sample	NNS
cord-006702-ekf6mja9	855	20	of	of	IN
cord-006702-ekf6mja9	855	21	healthy	healthy	JJ
cord-006702-ekf6mja9	855	22	donors	donor	NNS
cord-006702-ekf6mja9	855	23	(	(	-LRB-
cord-006702-ekf6mja9	855	24	n=10	n=10	NNP
cord-006702-ekf6mja9	855	25	,	,	,
cord-006702-ekf6mja9	855	26	age	age	NN
cord-006702-ekf6mja9	855	27	range	range	NN
cord-006702-ekf6mja9	855	28	4	4	CD
cord-006702-ekf6mja9	855	29	-	-	SYM
cord-006702-ekf6mja9	855	30	12	12	CD
cord-006702-ekf6mja9	855	31	y.o	y.o	NNP
cord-006702-ekf6mja9	855	32	)	)	-RRB-
cord-006702-ekf6mja9	855	33	and	and	CC
cord-006702-ekf6mja9	855	34	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	855	35	patients	patient	NNS
cord-006702-ekf6mja9	855	36	(	(	-LRB-
cord-006702-ekf6mja9	855	37	n=8	n=8	NN
cord-006702-ekf6mja9	855	38	,	,	,
cord-006702-ekf6mja9	855	39	age	age	NN
cord-006702-ekf6mja9	855	40	range	range	NN
cord-006702-ekf6mja9	855	41	4	4	CD
cord-006702-ekf6mja9	855	42	-	-	SYM
cord-006702-ekf6mja9	855	43	15	15	CD
cord-006702-ekf6mja9	855	44	y.	y.	NN
cord-006702-ekf6mja9	855	45	o	o	NN
cord-006702-ekf6mja9	855	46	)	)	-RRB-
cord-006702-ekf6mja9	855	47	.	.	.
cord-006702-ekf6mja9	856	1	Patients	patient	NNS
cord-006702-ekf6mja9	856	2	had	have	VBD
cord-006702-ekf6mja9	856	3	no	no	DT
cord-006702-ekf6mja9	856	4	kidney	kidney	NN
cord-006702-ekf6mja9	856	5	graft	graft	NN
cord-006702-ekf6mja9	856	6	.	.	.
cord-006702-ekf6mja9	857	1	The	the	DT
cord-006702-ekf6mja9	857	2	expression	expression	NN
cord-006702-ekf6mja9	857	3	of	of	IN
cord-006702-ekf6mja9	857	4	vimentin	vimentin	NN
cord-006702-ekf6mja9	857	5	was	be	VBD
cord-006702-ekf6mja9	857	6	correlated	correlate	VBN
cord-006702-ekf6mja9	857	7	to	to	IN
cord-006702-ekf6mja9	857	8	calibration	calibration	NN
cord-006702-ekf6mja9	857	9	curves	curve	NNS
cord-006702-ekf6mja9	857	10	derived	derive	VBN
cord-006702-ekf6mja9	857	11	from	from	IN
cord-006702-ekf6mja9	857	12	known	know	VBN
cord-006702-ekf6mja9	857	13	numbers	number	NNS
cord-006702-ekf6mja9	857	14	of	of	IN
cord-006702-ekf6mja9	857	15	adult	adult	NN
cord-006702-ekf6mja9	857	16	kidney	kidney	NN
cord-006702-ekf6mja9	857	17	progenitor	progenitor	NN
cord-006702-ekf6mja9	857	18	cells	cell	NNS
cord-006702-ekf6mja9	857	19	and	and	CC
cord-006702-ekf6mja9	857	20	normalized	normalize	VBN
cord-006702-ekf6mja9	857	21	to	to	IN
cord-006702-ekf6mja9	857	22	volume	volume	NN
cord-006702-ekf6mja9	857	23	of	of	IN
cord-006702-ekf6mja9	857	24	urine	urine	NN
cord-006702-ekf6mja9	857	25	.	.	.
cord-006702-ekf6mja9	858	1	We	-PRON-	PRP
cord-006702-ekf6mja9	858	2	cultured	culture	VBD
cord-006702-ekf6mja9	858	3	and	and	CC
cord-006702-ekf6mja9	858	4	characterized	characterize	VBD
cord-006702-ekf6mja9	858	5	urinary	urinary	JJ
cord-006702-ekf6mja9	858	6	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	858	7	progenitors	progenitor	NNS
cord-006702-ekf6mja9	858	8	by	by	IN
cord-006702-ekf6mja9	858	9	qPCR	qPCR	NNP
cord-006702-ekf6mja9	858	10	,	,	,
cord-006702-ekf6mja9	858	11	FACS	FACS	NNP
cord-006702-ekf6mja9	858	12	and	and	CC
cord-006702-ekf6mja9	858	13	immunofluorescence	immunofluorescence	NN
cord-006702-ekf6mja9	858	14	analysis	analysis	NN
cord-006702-ekf6mja9	858	15	.	.	.
cord-006702-ekf6mja9	859	1	Later	later	RB
cord-006702-ekf6mja9	859	2	we	-PRON-	PRP
cord-006702-ekf6mja9	859	3	differentiated	differentiate	VBD
cord-006702-ekf6mja9	859	4	progenitor	progenitor	NN
cord-006702-ekf6mja9	859	5	cells	cell	NNS
cord-006702-ekf6mja9	859	6	into	into	IN
cord-006702-ekf6mja9	859	7	functional	functional	JJ
cord-006702-ekf6mja9	859	8	podocytes	podocyte	NNS
cord-006702-ekf6mja9	859	9	and	and	CC
cord-006702-ekf6mja9	859	10	proximal	proximal	JJ
cord-006702-ekf6mja9	859	11	tubular	tubular	JJ
cord-006702-ekf6mja9	859	12	cells	cell	NNS
cord-006702-ekf6mja9	859	13	.	.	.
cord-006702-ekf6mja9	860	1	Results	result	NNS
cord-006702-ekf6mja9	861	1	:	:	:
cord-006702-ekf6mja9	861	2	We	-PRON-	PRP
cord-006702-ekf6mja9	861	3	demonstrate	demonstrate	VBP
cord-006702-ekf6mja9	861	4	a	a	DT
cord-006702-ekf6mja9	861	5	significant	significant	JJ
cord-006702-ekf6mja9	861	6	increased	increase	VBN
cord-006702-ekf6mja9	861	7	excretion	excretion	NN
cord-006702-ekf6mja9	861	8	of	of	IN
cord-006702-ekf6mja9	861	9	kidney	kidney	NN
cord-006702-ekf6mja9	861	10	progenitor	progenitor	NN
cord-006702-ekf6mja9	861	11	cells	cell	NNS
cord-006702-ekf6mja9	861	12	in	in	IN
cord-006702-ekf6mja9	861	13	cystinosis	cystinosis	NN
cord-006702-ekf6mja9	861	14	patients	patient	NNS
cord-006702-ekf6mja9	861	15	(	(	-LRB-
cord-006702-ekf6mja9	861	16	progenituria	progenituria	NNP
cord-006702-ekf6mja9	861	17	)	)	-RRB-
cord-006702-ekf6mja9	861	18	,	,	,
cord-006702-ekf6mja9	861	19	while	while	IN
cord-006702-ekf6mja9	861	20	in	in	IN
cord-006702-ekf6mja9	861	21	controls	control	NNS
cord-006702-ekf6mja9	861	22	no	no	DT
cord-006702-ekf6mja9	861	23	progenitors	progenitor	NNS
cord-006702-ekf6mja9	861	24	were	be	VBD
cord-006702-ekf6mja9	861	25	found	find	VBN
cord-006702-ekf6mja9	861	26	in	in	IN
cord-006702-ekf6mja9	861	27	urine	urine	NN
cord-006702-ekf6mja9	861	28	.	.	.
cord-006702-ekf6mja9	862	1	Progenitor	progenitor	NN
cord-006702-ekf6mja9	862	2	cells	cell	NNS
cord-006702-ekf6mja9	862	3	isolated	isolate	VBN
cord-006702-ekf6mja9	862	4	from	from	IN
cord-006702-ekf6mja9	862	5	cystinotic	cystinotic	JJ
cord-006702-ekf6mja9	862	6	urine	urine	NN
cord-006702-ekf6mja9	862	7	expressed	express	VBD
cord-006702-ekf6mja9	862	8	mesenchymal	mesenchymal	JJ
cord-006702-ekf6mja9	862	9	stem	stem	NN
cord-006702-ekf6mja9	862	10	cell	cell	NN
cord-006702-ekf6mja9	862	11	proteins	protein	NNS
cord-006702-ekf6mja9	862	12	and	and	CC
cord-006702-ekf6mja9	862	13	the	the	DT
cord-006702-ekf6mja9	862	14	kidney	kidney	NN
cord-006702-ekf6mja9	862	15	progenitor	progenitor	NN
cord-006702-ekf6mja9	862	16	markers	marker	NNS
cord-006702-ekf6mja9	862	17	CD24	CD24	NNP
cord-006702-ekf6mja9	862	18	and	and	CC
cord-006702-ekf6mja9	862	19	CD133	CD133	NNP
cord-006702-ekf6mja9	862	20	.	.	.
cord-006702-ekf6mja9	863	1	The	the	DT
cord-006702-ekf6mja9	863	2	cells	cell	NNS
cord-006702-ekf6mja9	863	3	were	be	VBD
cord-006702-ekf6mja9	863	4	positive	positive	JJ
cord-006702-ekf6mja9	863	5	for	for	IN
cord-006702-ekf6mja9	863	6	nephron	nephron	NN
cord-006702-ekf6mja9	863	7	progenitor	progenitor	NN
cord-006702-ekf6mja9	863	8	markers	marker	NNS
cord-006702-ekf6mja9	863	9	,	,	,
cord-006702-ekf6mja9	863	10	such	such	JJ
cord-006702-ekf6mja9	863	11	as	as	IN
cord-006702-ekf6mja9	863	12	Vimentin	Vimentin	NNP
cord-006702-ekf6mja9	863	13	,	,	,
cord-006702-ekf6mja9	863	14	PAX2	PAX2	NNP
cord-006702-ekf6mja9	863	15	and	and	CC
cord-006702-ekf6mja9	863	16	CITED1	cited1	NN
cord-006702-ekf6mja9	863	17	and	and	CC
cord-006702-ekf6mja9	863	18	were	be	VBD
cord-006702-ekf6mja9	863	19	able	able	JJ
cord-006702-ekf6mja9	863	20	to	to	TO
cord-006702-ekf6mja9	863	21	differentiate	differentiate	VB
cord-006702-ekf6mja9	863	22	into	into	IN
cord-006702-ekf6mja9	863	23	functional	functional	JJ
cord-006702-ekf6mja9	863	24	podocytes	podocyte	NNS
cord-006702-ekf6mja9	863	25	and	and	CC
cord-006702-ekf6mja9	863	26	proximal	proximal	JJ
cord-006702-ekf6mja9	863	27	tubular	tubular	JJ
cord-006702-ekf6mja9	863	28	cells	cell	NNS
cord-006702-ekf6mja9	863	29	.	.	.
cord-006702-ekf6mja9	864	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	864	2	:	:	:
cord-006702-ekf6mja9	865	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	865	2	data	datum	NNS
cord-006702-ekf6mja9	865	3	demonstrate	demonstrate	VBP
cord-006702-ekf6mja9	865	4	the	the	DT
cord-006702-ekf6mja9	865	5	presence	presence	NN
cord-006702-ekf6mja9	865	6	of	of	IN
cord-006702-ekf6mja9	865	7	kidney	kidney	NN
cord-006702-ekf6mja9	865	8	progenitor	progenitor	NN
cord-006702-ekf6mja9	865	9	cells	cell	NNS
cord-006702-ekf6mja9	865	10	in	in	IN
cord-006702-ekf6mja9	865	11	urine	urine	NN
cord-006702-ekf6mja9	865	12	of	of	IN
cord-006702-ekf6mja9	865	13	cystinotic	cystinotic	JJ
cord-006702-ekf6mja9	865	14	patients	patient	NNS
cord-006702-ekf6mja9	865	15	,	,	,
cord-006702-ekf6mja9	865	16	which	which	WDT
cord-006702-ekf6mja9	865	17	might	may	MD
cord-006702-ekf6mja9	865	18	indicate	indicate	VB
cord-006702-ekf6mja9	865	19	a	a	DT
cord-006702-ekf6mja9	865	20	fast	fast	JJ
cord-006702-ekf6mja9	865	21	turnover	turnover	NN
cord-006702-ekf6mja9	865	22	of	of	IN
cord-006702-ekf6mja9	865	23	cells	cell	NNS
cord-006702-ekf6mja9	865	24	and	and	CC
cord-006702-ekf6mja9	865	25	the	the	DT
cord-006702-ekf6mja9	865	26	attempt	attempt	NN
cord-006702-ekf6mja9	865	27	of	of	IN
cord-006702-ekf6mja9	865	28	tissue	tissue	NN
cord-006702-ekf6mja9	865	29	regeneration	regeneration	NN
cord-006702-ekf6mja9	865	30	to	to	TO
cord-006702-ekf6mja9	865	31	compensate	compensate	VB
cord-006702-ekf6mja9	865	32	cell	cell	NN
cord-006702-ekf6mja9	865	33	loss	loss	NN
cord-006702-ekf6mja9	865	34	.	.	.
cord-006702-ekf6mja9	866	1	Urinary	urinary	JJ
cord-006702-ekf6mja9	866	2	cystinotic	cystinotic	JJ
cord-006702-ekf6mja9	866	3	progenitor	progenitor	NN
cord-006702-ekf6mja9	866	4	cells	cell	NNS
cord-006702-ekf6mja9	866	5	might	may	MD
cord-006702-ekf6mja9	866	6	have	have	VB
cord-006702-ekf6mja9	866	7	a	a	DT
cord-006702-ekf6mja9	866	8	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	866	9	application	application	NN
cord-006702-ekf6mja9	866	10	in	in	IN
cord-006702-ekf6mja9	866	11	regenerative	regenerative	JJ
cord-006702-ekf6mja9	866	12	medicine	medicine	NN
cord-006702-ekf6mja9	866	13	once	once	IN
cord-006702-ekf6mja9	866	14	the	the	DT
cord-006702-ekf6mja9	866	15	correction	correction	NN
cord-006702-ekf6mja9	866	16	of	of	IN
cord-006702-ekf6mja9	866	17	the	the	DT
cord-006702-ekf6mja9	866	18	genetic	genetic	JJ
cord-006702-ekf6mja9	866	19	defect	defect	NN
cord-006702-ekf6mja9	866	20	and	and	CC
cord-006702-ekf6mja9	866	21	consequent	consequent	JJ
cord-006702-ekf6mja9	866	22	correction	correction	NN
cord-006702-ekf6mja9	866	23	of	of	IN
cord-006702-ekf6mja9	866	24	the	the	DT
cord-006702-ekf6mja9	866	25	phenotype	phenotype	NN
cord-006702-ekf6mja9	866	26	are	be	VBP
cord-006702-ekf6mja9	866	27	successful	successful	JJ
cord-006702-ekf6mja9	866	28	.	.	.
cord-006702-ekf6mja9	867	1	FP	FP	NNP
cord-006702-ekf6mja9	867	2	-	-	HYPH
cord-006702-ekf6mja9	867	3	S25	S25	NNP
cord-006702-ekf6mja9	867	4	-	-	HYPH
cord-006702-ekf6mja9	867	5	01	01	NNP
cord-006702-ekf6mja9	867	6	Study	Study	NNP
cord-006702-ekf6mja9	867	7	of	of	IN
cord-006702-ekf6mja9	867	8	hierarchical	hierarchical	JJ
cord-006702-ekf6mja9	867	9	management	management	NN
cord-006702-ekf6mja9	867	10	model	model	NN
cord-006702-ekf6mja9	867	11	of	of	IN
cord-006702-ekf6mja9	867	12	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	867	13	urine	urine	NN
cord-006702-ekf6mja9	867	14	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	867	15	in	in	IN
cord-006702-ekf6mja9	867	16	children	child	NNS
cord-006702-ekf6mja9	867	17	in	in	IN
cord-006702-ekf6mja9	867	18	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	867	19	Y.	Y.	NNP
cord-006702-ekf6mja9	867	20	gong	gong	NN
cord-006702-ekf6mja9	867	21	(	(	-LRB-
cord-006702-ekf6mja9	867	22	1	1	CD
cord-006702-ekf6mja9	867	23	)	)	-RRB-
cord-006702-ekf6mja9	867	24	,	,	.
cord-006702-ekf6mja9	868	1	X.	X.	NNP
cord-006702-ekf6mja9	868	2	Hong	Hong	NNP
cord-006702-ekf6mja9	868	3	(	(	-LRB-
cord-006702-ekf6mja9	868	4	1	1	CD
cord-006702-ekf6mja9	868	5	)	)	-RRB-
cord-006702-ekf6mja9	868	6	,	,	,
cord-006702-ekf6mja9	868	7	Q.	Q.	NNP
cord-006702-ekf6mja9	868	8	Shen	Shen	NNP
cord-006702-ekf6mja9	868	9	(	(	-LRB-
cord-006702-ekf6mja9	868	10	1	1	CD
cord-006702-ekf6mja9	868	11	)	)	-RRB-
cord-006702-ekf6mja9	868	12	,	,	,
cord-006702-ekf6mja9	868	13	Z.	Z.	NNP
cord-006702-ekf6mja9	868	14	Li	Li	NNP
cord-006702-ekf6mja9	868	15	(	(	-LRB-
cord-006702-ekf6mja9	868	16	2	2	CD
cord-006702-ekf6mja9	868	17	)	)	-RRB-
cord-006702-ekf6mja9	869	1	Objectives	objective	NNS
cord-006702-ekf6mja9	869	2	:	:	:
cord-006702-ekf6mja9	869	3	School	school	NN
cord-006702-ekf6mja9	869	4	urine	urine	NN
cord-006702-ekf6mja9	869	5	screening	screening	NN
cord-006702-ekf6mja9	869	6	can	can	MD
cord-006702-ekf6mja9	869	7	detect	detect	VB
cord-006702-ekf6mja9	869	8	a	a	DT
cord-006702-ekf6mja9	869	9	great	great	JJ
cord-006702-ekf6mja9	869	10	quantity	quantity	NN
cord-006702-ekf6mja9	869	11	cases	case	NNS
cord-006702-ekf6mja9	869	12	with	with	IN
cord-006702-ekf6mja9	869	13	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	869	14	urine	urine	NN
cord-006702-ekf6mja9	869	15	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	869	16	.	.	.
cord-006702-ekf6mja9	870	1	Long	long	JJ
cord-006702-ekf6mja9	870	2	-	-	HYPH
cord-006702-ekf6mja9	870	3	term	term	NN
cord-006702-ekf6mja9	870	4	follow	follow	NN
cord-006702-ekf6mja9	870	5	-	-	HYPH
cord-006702-ekf6mja9	870	6	up	up	NN
cord-006702-ekf6mja9	870	7	is	be	VBZ
cord-006702-ekf6mja9	870	8	necessary	necessary	JJ
cord-006702-ekf6mja9	870	9	for	for	IN
cord-006702-ekf6mja9	870	10	potential	potential	JJ
cord-006702-ekf6mja9	870	11	cases	case	NNS
cord-006702-ekf6mja9	870	12	with	with	IN
cord-006702-ekf6mja9	870	13	kidney	kidney	NN
cord-006702-ekf6mja9	870	14	diseases	disease	NNS
cord-006702-ekf6mja9	870	15	.	.	.
cord-006702-ekf6mja9	871	1	This	this	DT
cord-006702-ekf6mja9	871	2	project	project	NN
cord-006702-ekf6mja9	871	3	intends	intend	VBZ
cord-006702-ekf6mja9	871	4	to	to	TO
cord-006702-ekf6mja9	871	5	explore	explore	VB
cord-006702-ekf6mja9	871	6	the	the	DT
cord-006702-ekf6mja9	871	7	effective	effective	JJ
cord-006702-ekf6mja9	871	8	mode	mode	NN
cord-006702-ekf6mja9	871	9	of	of	IN
cord-006702-ekf6mja9	871	10	School	school	NN
cord-006702-ekf6mja9	871	11	urine	urine	NN
cord-006702-ekf6mja9	871	12	screening	screening	NN
cord-006702-ekf6mja9	871	13	network	network	NN
cord-006702-ekf6mja9	871	14	in	in	IN
cord-006702-ekf6mja9	871	15	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	871	16	.	.	.
cord-006702-ekf6mja9	872	1	Methods	method	NNS
cord-006702-ekf6mja9	872	2	:	:	:
cord-006702-ekf6mja9	872	3	During	during	IN
cord-006702-ekf6mja9	872	4	2013.9	2013.9	CD
cord-006702-ekf6mja9	872	5	to	to	IN
cord-006702-ekf6mja9	872	6	2015.8	2015.8	CD
cord-006702-ekf6mja9	872	7	,	,	,
cord-006702-ekf6mja9	872	8	a	a	DT
cord-006702-ekf6mja9	872	9	hierarchical	hierarchical	JJ
cord-006702-ekf6mja9	872	10	medical	medical	JJ
cord-006702-ekf6mja9	872	11	model	model	NN
cord-006702-ekf6mja9	872	12	in	in	IN
cord-006702-ekf6mja9	872	13	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	872	14	hematuria	hematuria	NN
cord-006702-ekf6mja9	872	15	children	child	NNS
cord-006702-ekf6mja9	872	16	was	be	VBD
cord-006702-ekf6mja9	872	17	built	build	VBN
cord-006702-ekf6mja9	872	18	in	in	IN
cord-006702-ekf6mja9	872	19	three	three	CD
cord-006702-ekf6mja9	872	20	districts	district	NNS
cord-006702-ekf6mja9	872	21	in	in	IN
cord-006702-ekf6mja9	872	22	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	872	23	.	.	.
cord-006702-ekf6mja9	873	1	The	the	DT
cord-006702-ekf6mja9	873	2	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	873	3	hematuria	hematuria	NN
cord-006702-ekf6mja9	873	4	children	child	NNS
cord-006702-ekf6mja9	873	5	were	be	VBD
cord-006702-ekf6mja9	873	6	founded	found	VBN
cord-006702-ekf6mja9	873	7	by	by	IN
cord-006702-ekf6mja9	873	8	school	school	NN
cord-006702-ekf6mja9	873	9	urine	urine	NN
cord-006702-ekf6mja9	873	10	screening	screening	NN
cord-006702-ekf6mja9	873	11	program	program	NN
cord-006702-ekf6mja9	873	12	.	.	.
cord-006702-ekf6mja9	874	1	They	-PRON-	PRP
cord-006702-ekf6mja9	874	2	were	be	VBD
cord-006702-ekf6mja9	874	3	confirmed	confirm	VBN
cord-006702-ekf6mja9	874	4	and	and	CC
cord-006702-ekf6mja9	874	5	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	874	6	in	in	IN
cord-006702-ekf6mja9	874	7	the	the	DT
cord-006702-ekf6mja9	874	8	district	district	NN
cord-006702-ekf6mja9	874	9	central	central	JJ
cord-006702-ekf6mja9	874	10	hospitals	hospital	NNS
cord-006702-ekf6mja9	874	11	.	.	.
cord-006702-ekf6mja9	875	1	Tertiary	tertiary	JJ
cord-006702-ekf6mja9	875	2	referral	referral	NN
cord-006702-ekf6mja9	875	3	needed	need	VBN
cord-006702-ekf6mja9	875	4	in	in	IN
cord-006702-ekf6mja9	875	5	some	some	DT
cord-006702-ekf6mja9	875	6	patients	patient	NNS
cord-006702-ekf6mja9	875	7	.	.	.
cord-006702-ekf6mja9	876	1	Results	result	NNS
cord-006702-ekf6mja9	876	2	:	:	:
cord-006702-ekf6mja9	876	3	1	1	CD
cord-006702-ekf6mja9	876	4	.	.	.
cord-006702-ekf6mja9	877	1	Model	Model	NNP
cord-006702-ekf6mja9	877	2	building1	building1	NN
cord-006702-ekf6mja9	877	3	)	)	-RRB-
cord-006702-ekf6mja9	878	1	The	the	DT
cord-006702-ekf6mja9	878	2	3	3	CD
cord-006702-ekf6mja9	878	3	level	level	NN
cord-006702-ekf6mja9	878	4	transferring	transfer	VBG
cord-006702-ekf6mja9	878	5	system	system	NN
cord-006702-ekf6mja9	878	6	consisted	consist	VBD
cord-006702-ekf6mja9	878	7	of	of	IN
cord-006702-ekf6mja9	878	8	school	school	NN
cord-006702-ekf6mja9	878	9	urine	urine	NN
cord-006702-ekf6mja9	878	10	screening	screening	NN
cord-006702-ekf6mja9	878	11	agencies	agency	NNS
cord-006702-ekf6mja9	878	12	,	,	,
cord-006702-ekf6mja9	878	13	local	local	JJ
cord-006702-ekf6mja9	878	14	district	district	NN
cord-006702-ekf6mja9	878	15	cental	cental	NNP
cord-006702-ekf6mja9	878	16	hospital	hospital	NNP
cord-006702-ekf6mja9	878	17	and	and	CC
cord-006702-ekf6mja9	878	18	Children	Children	NNP
cord-006702-ekf6mja9	878	19	's	's	POS
cord-006702-ekf6mja9	878	20	Hospital	Hospital	NNP
cord-006702-ekf6mja9	878	21	of	of	IN
cord-006702-ekf6mja9	878	22	Fudan	Fudan	NNP
cord-006702-ekf6mja9	878	23	University	University	NNP
cord-006702-ekf6mja9	878	24	(	(	-LRB-
cord-006702-ekf6mja9	878	25	CHFU	CHFU	NNP
cord-006702-ekf6mja9	878	26	)	)	-RRB-
cord-006702-ekf6mja9	878	27	,	,	,
cord-006702-ekf6mja9	878	28	a	a	DT
cord-006702-ekf6mja9	878	29	tertiary	tertiary	JJ
cord-006702-ekf6mja9	878	30	pediatric	pediatric	JJ
cord-006702-ekf6mja9	878	31	nephrology	nephrology	NN
cord-006702-ekf6mja9	878	32	center	center	NN
cord-006702-ekf6mja9	878	33	.	.	.
cord-006702-ekf6mja9	879	1	2	2	LS
cord-006702-ekf6mja9	879	2	)	)	-RRB-
cord-006702-ekf6mja9	880	1	There	there	EX
cord-006702-ekf6mja9	880	2	were	be	VBD
cord-006702-ekf6mja9	880	3	three	three	CD
cord-006702-ekf6mja9	880	4	models	model	NNS
cord-006702-ekf6mja9	880	5	of	of	IN
cord-006702-ekf6mja9	880	6	school	school	NN
cord-006702-ekf6mja9	880	7	urine	urine	NN
cord-006702-ekf6mja9	880	8	screening	screening	NN
cord-006702-ekf6mja9	880	9	in	in	IN
cord-006702-ekf6mja9	880	10	accordance	accordance	NN
cord-006702-ekf6mja9	880	11	with	with	IN
cord-006702-ekf6mja9	880	12	three	three	CD
cord-006702-ekf6mja9	880	13	different	different	JJ
cord-006702-ekf6mja9	880	14	screening	screening	NN
cord-006702-ekf6mja9	880	15	agencies	agency	NNS
cord-006702-ekf6mja9	880	16	,	,	,
cord-006702-ekf6mja9	880	17	community	community	NN
cord-006702-ekf6mja9	880	18	health	health	NN
cord-006702-ekf6mja9	880	19	service	service	NN
cord-006702-ekf6mja9	880	20	centers	center	NNS
cord-006702-ekf6mja9	880	21	(	(	-LRB-
cord-006702-ekf6mja9	880	22	CHSC	CHSC	NNP
cord-006702-ekf6mja9	880	23	,	,	,
cord-006702-ekf6mja9	880	24	Model	Model	NNP
cord-006702-ekf6mja9	880	25	A	A	NNP
cord-006702-ekf6mja9	880	26	)	)	-RRB-
cord-006702-ekf6mja9	880	27	,	,	,
cord-006702-ekf6mja9	880	28	Center	Center	NNP
cord-006702-ekf6mja9	880	29	for	for	IN
cord-006702-ekf6mja9	880	30	Disease	Disease	NNP
cord-006702-ekf6mja9	880	31	Control	Control	NNP
cord-006702-ekf6mja9	880	32	and	and	CC
cord-006702-ekf6mja9	880	33	Prevention	Prevention	NNP
cord-006702-ekf6mja9	880	34	(	(	-LRB-
cord-006702-ekf6mja9	880	35	CDC	CDC	NNP
cord-006702-ekf6mja9	880	36	,	,	,
cord-006702-ekf6mja9	880	37	Model	Model	NNP
cord-006702-ekf6mja9	880	38	B	B	NNP
cord-006702-ekf6mja9	880	39	)	)	-RRB-
cord-006702-ekf6mja9	880	40	and	and	CC
cord-006702-ekf6mja9	880	41	Physical	Physical	NNP
cord-006702-ekf6mja9	880	42	Examination	Examination	NNP
cord-006702-ekf6mja9	880	43	Department	Department	NNP
cord-006702-ekf6mja9	880	44	(	(	-LRB-
cord-006702-ekf6mja9	880	45	Model	Model	NNP
cord-006702-ekf6mja9	880	46	C	C	NNP
cord-006702-ekf6mja9	880	47	)	)	-RRB-
cord-006702-ekf6mja9	880	48	,	,	,
cord-006702-ekf6mja9	880	49	respectively	respectively	RB
cord-006702-ekf6mja9	880	50	.	.	.
cord-006702-ekf6mja9	881	1	2	2	LS
cord-006702-ekf6mja9	881	2	.	.	.
cord-006702-ekf6mja9	882	1	Practical	Practical	NNP
cord-006702-ekf6mja9	882	2	Study	Study	NNP
cord-006702-ekf6mja9	882	3	1	1	CD
cord-006702-ekf6mja9	882	4	)	)	-RRB-
cord-006702-ekf6mja9	882	5	40999	40999	CD
cord-006702-ekf6mja9	883	1	students	student	NNS
cord-006702-ekf6mja9	883	2	were	be	VBD
cord-006702-ekf6mja9	883	3	screened	screen	VBN
cord-006702-ekf6mja9	883	4	in	in	IN
cord-006702-ekf6mja9	883	5	this	this	DT
cord-006702-ekf6mja9	883	6	project	project	NN
cord-006702-ekf6mja9	883	7	,	,	,
cord-006702-ekf6mja9	883	8	the	the	DT
cord-006702-ekf6mja9	883	9	prevalence	prevalence	NN
cord-006702-ekf6mja9	883	10	of	of	IN
cord-006702-ekf6mja9	883	11	urine	urine	NN
cord-006702-ekf6mja9	883	12	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	883	13	was	be	VBD
cord-006702-ekf6mja9	883	14	1.06	1.06	CD
cord-006702-ekf6mja9	883	15	%	%	NN
cord-006702-ekf6mja9	883	16	in	in	IN
cord-006702-ekf6mja9	883	17	elementary	elementary	JJ
cord-006702-ekf6mja9	883	18	school	school	NN
cord-006702-ekf6mja9	883	19	students	student	NNS
cord-006702-ekf6mja9	883	20	and	and	CC
cord-006702-ekf6mja9	883	21	1.44	1.44	CD
cord-006702-ekf6mja9	883	22	%	%	NN
cord-006702-ekf6mja9	883	23	in	in	IN
cord-006702-ekf6mja9	883	24	junior	junior	JJ
cord-006702-ekf6mja9	883	25	middle	middle	JJ
cord-006702-ekf6mja9	883	26	school	school	NN
cord-006702-ekf6mja9	883	27	students	student	NNS
cord-006702-ekf6mja9	883	28	.	.	.
cord-006702-ekf6mja9	884	1	2	2	LS
cord-006702-ekf6mja9	884	2	)	)	-RRB-
cord-006702-ekf6mja9	885	1	80	80	CD
cord-006702-ekf6mja9	885	2	%	%	NN
cord-006702-ekf6mja9	885	3	of	of	IN
cord-006702-ekf6mja9	885	4	cases	case	NNS
cord-006702-ekf6mja9	885	5	went	go	VBD
cord-006702-ekf6mja9	885	6	to	to	IN
cord-006702-ekf6mja9	885	7	the	the	DT
cord-006702-ekf6mja9	885	8	district	district	NN
cord-006702-ekf6mja9	885	9	cental	cental	JJ
cord-006702-ekf6mja9	885	10	hospitals	hospital	NNS
cord-006702-ekf6mja9	885	11	in	in	IN
cord-006702-ekf6mja9	885	12	Model	Model	NNP
cord-006702-ekf6mja9	885	13	A	A	NNP
cord-006702-ekf6mja9	885	14	,	,	,
cord-006702-ekf6mja9	885	15	100	100	CD
cord-006702-ekf6mja9	885	16	%	%	NN
cord-006702-ekf6mja9	885	17	in	in	IN
cord-006702-ekf6mja9	885	18	Model	Model	NNP
cord-006702-ekf6mja9	885	19	B	B	NNP
cord-006702-ekf6mja9	885	20	while	while	IN
cord-006702-ekf6mja9	885	21	only	only	RB
cord-006702-ekf6mja9	885	22	24.6	24.6	CD
cord-006702-ekf6mja9	885	23	%	%	NN
cord-006702-ekf6mja9	885	24	in	in	IN
cord-006702-ekf6mja9	885	25	Model	Model	NNP
cord-006702-ekf6mja9	885	26	C.	C.	NNP
cord-006702-ekf6mja9	885	27	Totally	totally	RB
cord-006702-ekf6mja9	885	28	66	66	CD
cord-006702-ekf6mja9	885	29	cases	case	NNS
cord-006702-ekf6mja9	885	30	of	of	IN
cord-006702-ekf6mja9	885	31	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	885	32	hematuria	hematuria	NN
cord-006702-ekf6mja9	885	33	,	,	,
cord-006702-ekf6mja9	885	34	2	2	CD
cord-006702-ekf6mja9	885	35	of	of	IN
cord-006702-ekf6mja9	885	36	mass	mass	JJ
cord-006702-ekf6mja9	885	37	hematuria	hematuria	NN
cord-006702-ekf6mja9	885	38	and	and	CC
cord-006702-ekf6mja9	885	39	4	4	CD
cord-006702-ekf6mja9	885	40	of	of	IN
cord-006702-ekf6mja9	885	41	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	885	42	.	.	.
cord-006702-ekf6mja9	886	1	Of	of	IN
cord-006702-ekf6mja9	886	2	those	those	DT
cord-006702-ekf6mja9	886	3	,	,	,
cord-006702-ekf6mja9	886	4	about	about	RB
cord-006702-ekf6mja9	886	5	15	15	CD
cord-006702-ekf6mja9	886	6	%	%	NN
cord-006702-ekf6mja9	886	7	of	of	IN
cord-006702-ekf6mja9	886	8	cases	case	NNS
cord-006702-ekf6mja9	886	9	met	meet	VBD
cord-006702-ekf6mja9	886	10	the	the	DT
cord-006702-ekf6mja9	886	11	criteria	criterion	NNS
cord-006702-ekf6mja9	886	12	transferring	transfer	VBG
cord-006702-ekf6mja9	886	13	to	to	IN
cord-006702-ekf6mja9	886	14	CHFU	CHFU	NNP
cord-006702-ekf6mja9	886	15	and	and	CC
cord-006702-ekf6mja9	886	16	90.9	90.9	CD
cord-006702-ekf6mja9	886	17	%	%	NN
cord-006702-ekf6mja9	886	18	completed	complete	VBD
cord-006702-ekf6mja9	886	19	the	the	DT
cord-006702-ekf6mja9	886	20	referral	referral	NN
cord-006702-ekf6mja9	886	21	.	.	.
cord-006702-ekf6mja9	887	1	All	all	PDT
cord-006702-ekf6mja9	887	2	the	the	DT
cord-006702-ekf6mja9	887	3	72	72	CD
cord-006702-ekf6mja9	887	4	cases	case	NNS
cord-006702-ekf6mja9	887	5	got	get	VBD
cord-006702-ekf6mja9	887	6	followed	follow	VBN
cord-006702-ekf6mja9	887	7	up	up	RP
cord-006702-ekf6mja9	887	8	,	,	,
cord-006702-ekf6mja9	887	9	2	2	CD
cord-006702-ekf6mja9	887	10	cases	case	NNS
cord-006702-ekf6mja9	887	11	of	of	IN
cord-006702-ekf6mja9	887	12	Alport	Alport	NNP
cord-006702-ekf6mja9	887	13	syndrome	syndrome	NN
cord-006702-ekf6mja9	887	14	and	and	CC
cord-006702-ekf6mja9	887	15	1	1	CD
cord-006702-ekf6mja9	887	16	of	of	IN
cord-006702-ekf6mja9	887	17	Chronic	Chronic	NNP
cord-006702-ekf6mja9	887	18	Interstitial	Interstitial	NNP
cord-006702-ekf6mja9	887	19	Nephritis	Nephritis	NNP
cord-006702-ekf6mja9	887	20	.	.	.
cord-006702-ekf6mja9	888	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	888	2	:	:	:
cord-006702-ekf6mja9	889	1	Hierarchical	hierarchical	JJ
cord-006702-ekf6mja9	889	2	medical	medical	JJ
cord-006702-ekf6mja9	889	3	model	model	NN
cord-006702-ekf6mja9	889	4	for	for	IN
cord-006702-ekf6mja9	889	5	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	889	6	hematuria	hematuria	NN
cord-006702-ekf6mja9	889	7	patients	patient	NNS
cord-006702-ekf6mja9	889	8	was	be	VBD
cord-006702-ekf6mja9	889	9	feasible	feasible	JJ
cord-006702-ekf6mja9	889	10	and	and	CC
cord-006702-ekf6mja9	889	11	helpful	helpful	JJ
cord-006702-ekf6mja9	889	12	for	for	IN
cord-006702-ekf6mja9	889	13	the	the	DT
cord-006702-ekf6mja9	889	14	follow	follow	NN
cord-006702-ekf6mja9	889	15	-	-	HYPH
cord-006702-ekf6mja9	889	16	up	up	NN
cord-006702-ekf6mja9	889	17	of	of	IN
cord-006702-ekf6mja9	889	18	potential	potential	JJ
cord-006702-ekf6mja9	889	19	patients	patient	NNS
cord-006702-ekf6mja9	889	20	with	with	IN
cord-006702-ekf6mja9	889	21	kidney	kidney	NN
cord-006702-ekf6mja9	889	22	disease	disease	NN
cord-006702-ekf6mja9	889	23	.	.	.
cord-006702-ekf6mja9	890	1	The	the	DT
cord-006702-ekf6mja9	890	2	complement	complement	NN
cord-006702-ekf6mja9	890	3	system	system	NN
cord-006702-ekf6mja9	890	4	is	be	VBZ
cord-006702-ekf6mja9	890	5	highly	highly	RB
cord-006702-ekf6mja9	890	6	activated	activate	VBN
cord-006702-ekf6mja9	890	7	in	in	IN
cord-006702-ekf6mja9	890	8	PD	PD	NNP
cord-006702-ekf6mja9	890	9	associated	associate	VBD
cord-006702-ekf6mja9	890	10	arteriolopathy	arteriolopathy	NNP
cord-006702-ekf6mja9	890	11	B.	B.	NNP
cord-006702-ekf6mja9	890	12	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	890	13	(	(	-LRB-
cord-006702-ekf6mja9	890	14	1	1	CD
cord-006702-ekf6mja9	890	15	)	)	-RRB-
cord-006702-ekf6mja9	890	16	,	,	,
cord-006702-ekf6mja9	890	17	M.	M.	NNP
cord-006702-ekf6mja9	890	18	Bartosova	Bartosova	NNP
cord-006702-ekf6mja9	890	19	(	(	-LRB-
cord-006702-ekf6mja9	890	20	1	1	CD
cord-006702-ekf6mja9	890	21	)	)	-RRB-
cord-006702-ekf6mja9	890	22	,	,	,
cord-006702-ekf6mja9	890	23	J.	J.	NNP
cord-006702-ekf6mja9	890	24	Lorenzo	Lorenzo	NNP
cord-006702-ekf6mja9	890	25	(	(	-LRB-
cord-006702-ekf6mja9	890	26	2	2	CD
cord-006702-ekf6mja9	890	27	)	)	-RRB-
cord-006702-ekf6mja9	890	28	,	,	,
cord-006702-ekf6mja9	890	29	S.	S.	NNP
cord-006702-ekf6mja9	890	30	Tarantino	Tarantino	NNP
cord-006702-ekf6mja9	890	31	(	(	-LRB-
cord-006702-ekf6mja9	890	32	3	3	CD
cord-006702-ekf6mja9	890	33	)	)	-RRB-
cord-006702-ekf6mja9	890	34	,	,	,
cord-006702-ekf6mja9	890	35	R.	R.	NNP
cord-006702-ekf6mja9	890	36	Büscher	Büscher	NNP
cord-006702-ekf6mja9	890	37	(	(	-LRB-
cord-006702-ekf6mja9	890	38	4	4	CD
cord-006702-ekf6mja9	890	39	)	)	-RRB-
cord-006702-ekf6mja9	890	40	,	,	,
cord-006702-ekf6mja9	890	41	C.	C.	NNP
cord-006702-ekf6mja9	890	42	Aufricht	Aufricht	NNP
cord-006702-ekf6mja9	890	43	(	(	-LRB-
cord-006702-ekf6mja9	890	44	5	5	CD
cord-006702-ekf6mja9	890	45	)	)	-RRB-
cord-006702-ekf6mja9	890	46	,	,	,
cord-006702-ekf6mja9	890	47	K.	K.	NNP
cord-006702-ekf6mja9	890	48	Kratochwill	Kratochwill	NNP
cord-006702-ekf6mja9	890	49	(	(	-LRB-
cord-006702-ekf6mja9	890	50	3	3	CD
cord-006702-ekf6mja9	890	51	)	)	-RRB-
cord-006702-ekf6mja9	890	52	,	,	,
cord-006702-ekf6mja9	890	53	C.P.	C.P.	NNP
cord-006702-ekf6mja9	890	54	Schmitt	Schmitt	NNP
cord-006702-ekf6mja9	890	55	(	(	-LRB-
cord-006702-ekf6mja9	890	56	1	1	CD
cord-006702-ekf6mja9	890	57	)	)	-RRB-
cord-006702-ekf6mja9	891	1	(	(	-LRB-
cord-006702-ekf6mja9	891	2	1	1	LS
cord-006702-ekf6mja9	891	3	)	)	-RRB-
cord-006702-ekf6mja9	891	4	University	University	NNP
cord-006702-ekf6mja9	891	5	of	of	IN
cord-006702-ekf6mja9	891	6	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	891	7	,	,	,
cord-006702-ekf6mja9	891	8	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	891	9	,	,	,
cord-006702-ekf6mja9	891	10	Germany	Germany	NNP
cord-006702-ekf6mja9	891	11	;	;	:
cord-006702-ekf6mja9	891	12	(	(	-LRB-
cord-006702-ekf6mja9	891	13	2	2	LS
cord-006702-ekf6mja9	891	14	)	)	-RRB-
cord-006702-ekf6mja9	891	15	Institute	Institute	NNP
cord-006702-ekf6mja9	891	16	of	of	IN
cord-006702-ekf6mja9	891	17	Medical	Medical	NNP
cord-006702-ekf6mja9	891	18	Biometry	Biometry	NNP
cord-006702-ekf6mja9	891	19	and	and	CC
cord-006702-ekf6mja9	891	20	Informatics	Informatics	NNP
cord-006702-ekf6mja9	891	21	,	,	,
cord-006702-ekf6mja9	891	22	University	University	NNP
cord-006702-ekf6mja9	891	23	Hospital	Hospital	NNP
cord-006702-ekf6mja9	891	24	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	891	25	,	,	,
cord-006702-ekf6mja9	891	26	Heidelberg	Heidelberg	NNP
cord-006702-ekf6mja9	891	27	,	,	,
cord-006702-ekf6mja9	891	28	Germany	Germany	NNP
cord-006702-ekf6mja9	891	29	;	;	:
cord-006702-ekf6mja9	891	30	(	(	-LRB-
cord-006702-ekf6mja9	891	31	3	3	LS
cord-006702-ekf6mja9	891	32	)	)	-RRB-
cord-006702-ekf6mja9	891	33	Zytoprotec	Zytoprotec	NNP
cord-006702-ekf6mja9	891	34	GmbH	GmbH	NNP
cord-006702-ekf6mja9	891	35	,	,	,
cord-006702-ekf6mja9	891	36	Vienna	Vienna	NNP
cord-006702-ekf6mja9	891	37	,	,	,
cord-006702-ekf6mja9	891	38	Austria	Austria	NNP
cord-006702-ekf6mja9	891	39	;	;	:
cord-006702-ekf6mja9	891	40	(	(	-LRB-
cord-006702-ekf6mja9	891	41	4	4	LS
cord-006702-ekf6mja9	891	42	)	)	-RRB-
cord-006702-ekf6mja9	891	43	Department	Department	NNP
cord-006702-ekf6mja9	891	44	of	of	IN
cord-006702-ekf6mja9	891	45	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	891	46	II	II	NNP
cord-006702-ekf6mja9	891	47	,	,	,
cord-006702-ekf6mja9	891	48	University	University	NNP
cord-006702-ekf6mja9	891	49	Hospital	Hospital	NNP
cord-006702-ekf6mja9	891	50	Essen	Essen	NNP
cord-006702-ekf6mja9	891	51	,	,	,
cord-006702-ekf6mja9	891	52	Essen	Essen	NNP
cord-006702-ekf6mja9	891	53	,	,	,
cord-006702-ekf6mja9	891	54	Germany	Germany	NNP
cord-006702-ekf6mja9	891	55	;	;	:
cord-006702-ekf6mja9	891	56	(	(	-LRB-
cord-006702-ekf6mja9	891	57	5	5	LS
cord-006702-ekf6mja9	891	58	)	)	-RRB-
cord-006702-ekf6mja9	891	59	Department	Department	NNP
cord-006702-ekf6mja9	891	60	of	of	IN
cord-006702-ekf6mja9	891	61	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	891	62	and	and	CC
cord-006702-ekf6mja9	891	63	Adolescent	Adolescent	NNP
cord-006702-ekf6mja9	891	64	Medicine	Medicine	NNP
cord-006702-ekf6mja9	891	65	,	,	,
cord-006702-ekf6mja9	891	66	Medical	Medical	NNP
cord-006702-ekf6mja9	891	67	University	University	NNP
cord-006702-ekf6mja9	891	68	of	of	IN
cord-006702-ekf6mja9	891	69	Vienna	Vienna	NNP
cord-006702-ekf6mja9	891	70	,	,	,
cord-006702-ekf6mja9	891	71	Vienna	Vienna	NNP
cord-006702-ekf6mja9	891	72	,	,	,
cord-006702-ekf6mja9	892	1	Austria	Austria	NNP
cord-006702-ekf6mja9	892	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	892	3	:	:	:
cord-006702-ekf6mja9	893	1	Cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	893	2	disease	disease	NN
cord-006702-ekf6mja9	893	3	is	be	VBZ
cord-006702-ekf6mja9	893	4	the	the	DT
cord-006702-ekf6mja9	893	5	leading	leading	JJ
cord-006702-ekf6mja9	893	6	cause	cause	NN
cord-006702-ekf6mja9	893	7	of	of	IN
cord-006702-ekf6mja9	893	8	death	death	NN
cord-006702-ekf6mja9	893	9	in	in	IN
cord-006702-ekf6mja9	893	10	children	child	NNS
cord-006702-ekf6mja9	893	11	on	on	IN
cord-006702-ekf6mja9	893	12	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	893	13	dialysis	dialysis	NN
cord-006702-ekf6mja9	893	14	(	(	-LRB-
cord-006702-ekf6mja9	893	15	PD	PD	NNP
cord-006702-ekf6mja9	893	16	)	)	-RRB-
cord-006702-ekf6mja9	893	17	,	,	,
cord-006702-ekf6mja9	893	18	underlying	underlie	VBG
cord-006702-ekf6mja9	893	19	mechanisms	mechanism	NNS
cord-006702-ekf6mja9	893	20	are	be	VBP
cord-006702-ekf6mja9	893	21	still	still	RB
cord-006702-ekf6mja9	893	22	incompletely	incompletely	RB
cord-006702-ekf6mja9	893	23	understood	understand	VBN
cord-006702-ekf6mja9	893	24	.	.	.
cord-006702-ekf6mja9	894	1	Methods	method	NNS
cord-006702-ekf6mja9	894	2	:	:	:
cord-006702-ekf6mja9	894	3	Omental	Omental	NNP
cord-006702-ekf6mja9	894	4	arterioles	arteriole	NNS
cord-006702-ekf6mja9	894	5	covered	cover	VBN
cord-006702-ekf6mja9	894	6	with	with	IN
cord-006702-ekf6mja9	894	7	fat	fat	NN
cord-006702-ekf6mja9	894	8	,	,	,
cord-006702-ekf6mja9	894	9	i.e.	i.e.	FW
cord-006702-ekf6mja9	894	10	located	locate	VBN
cord-006702-ekf6mja9	894	11	beyond	beyond	IN
cord-006702-ekf6mja9	894	12	PD	PD	NNP
cord-006702-ekf6mja9	894	13	fluid	fluid	JJ
cord-006702-ekf6mja9	894	14	penetration	penetration	NN
cord-006702-ekf6mja9	894	15	level	level	NN
cord-006702-ekf6mja9	894	16	were	be	VBD
cord-006702-ekf6mja9	894	17	microdissected	microdissecte	VBN
cord-006702-ekf6mja9	894	18	from	from	IN
cord-006702-ekf6mja9	894	19	non	non	JJ
cord-006702-ekf6mja9	894	20	-	-	JJ
cord-006702-ekf6mja9	894	21	uremic	uremic	JJ
cord-006702-ekf6mja9	894	22	children	child	NNS
cord-006702-ekf6mja9	894	23	,	,	,
cord-006702-ekf6mja9	894	24	age	age	NN
cord-006702-ekf6mja9	894	25	and	and	CC
cord-006702-ekf6mja9	894	26	gender	gender	NN
cord-006702-ekf6mja9	894	27	matched	match	VBN
cord-006702-ekf6mja9	894	28	children	child	NNS
cord-006702-ekf6mja9	894	29	at	at	IN
cord-006702-ekf6mja9	894	30	time	time	NN
cord-006702-ekf6mja9	894	31	of	of	IN
cord-006702-ekf6mja9	894	32	first	first	JJ
cord-006702-ekf6mja9	894	33	PD	PD	NNP
cord-006702-ekf6mja9	894	34	catheter	catheter	NN
cord-006702-ekf6mja9	894	35	insertion	insertion	NN
cord-006702-ekf6mja9	894	36	and	and	CC
cord-006702-ekf6mja9	894	37	children	child	NNS
cord-006702-ekf6mja9	894	38	treated	treat	VBN
cord-006702-ekf6mja9	894	39	with	with	IN
cord-006702-ekf6mja9	894	40	low	low	JJ
cord-006702-ekf6mja9	894	41	GDP	GDP	NNP
cord-006702-ekf6mja9	894	42	PD	PD	NNP
cord-006702-ekf6mja9	894	43	fluids	fluid	NNS
cord-006702-ekf6mja9	894	44	[	[	-LRB-
cord-006702-ekf6mja9	894	45	PD	PD	NNP
cord-006702-ekf6mja9	894	46	vintage	vintage	NN
cord-006702-ekf6mja9	894	47	26	26	CD
cord-006702-ekf6mja9	894	48	;	;	:
cord-006702-ekf6mja9	894	49	2	2	CD
cord-006702-ekf6mja9	894	50	-	-	SYM
cord-006702-ekf6mja9	894	51	72	72	CD
cord-006702-ekf6mja9	894	52	months	month	NNS
cord-006702-ekf6mja9	894	53	)	)	-RRB-
cord-006702-ekf6mja9	894	54	.	.	.
cord-006702-ekf6mja9	895	1	Children	child	NNS
cord-006702-ekf6mja9	895	2	with	with	IN
cord-006702-ekf6mja9	895	3	diseases	disease	NNS
cord-006702-ekf6mja9	895	4	potentially	potentially	RB
cord-006702-ekf6mja9	895	5	affecting	affect	VBG
cord-006702-ekf6mja9	895	6	vessel	vessel	NN
cord-006702-ekf6mja9	895	7	integrity	integrity	NN
cord-006702-ekf6mja9	895	8	were	be	VBD
cord-006702-ekf6mja9	895	9	excluded	exclude	VBN
cord-006702-ekf6mja9	895	10	.	.	.
cord-006702-ekf6mja9	896	1	3	3	LS
cord-006702-ekf6mja9	896	2	-	-	SYM
cord-006702-ekf6mja9	896	3	4	4	CD
cord-006702-ekf6mja9	896	4	arterioles	arteriole	NNS
cord-006702-ekf6mja9	896	5	per	per	IN
cord-006702-ekf6mja9	896	6	patient	patient	NN
cord-006702-ekf6mja9	896	7	with	with	IN
cord-006702-ekf6mja9	896	8	similar	similar	JJ
cord-006702-ekf6mja9	896	9	structural	structural	JJ
cord-006702-ekf6mja9	896	10	dimensions	dimension	NNS
cord-006702-ekf6mja9	896	11	(	(	-LRB-
cord-006702-ekf6mja9	896	12	as	as	IN
cord-006702-ekf6mja9	896	13	defined	define	VBN
cord-006702-ekf6mja9	896	14	by	by	IN
cord-006702-ekf6mja9	896	15	Aperio	Aperio	NNP
cord-006702-ekf6mja9	897	1	®	®	,
cord-006702-ekf6mja9	897	2	automated	automated	JJ
cord-006702-ekf6mja9	897	3	image	image	NN
cord-006702-ekf6mja9	897	4	analysis	analysis	NN
cord-006702-ekf6mja9	897	5	after	after	IN
cord-006702-ekf6mja9	897	6	EVG	EVG	NNP
cord-006702-ekf6mja9	897	7	staining	staining	NN
cord-006702-ekf6mja9	897	8	vessels	vessel	NNS
cord-006702-ekf6mja9	897	9	)	)	-RRB-
cord-006702-ekf6mja9	897	10	were	be	VBD
cord-006702-ekf6mja9	897	11	selected	select	VBN
cord-006702-ekf6mja9	897	12	,	,	,
cord-006702-ekf6mja9	897	13	neighboured	neighboured	JJ
cord-006702-ekf6mja9	897	14	sections	section	NNS
cord-006702-ekf6mja9	897	15	were	be	VBD
cord-006702-ekf6mja9	897	16	used	use	VBN
cord-006702-ekf6mja9	897	17	for	for	IN
cord-006702-ekf6mja9	897	18	whole	whole	JJ
cord-006702-ekf6mja9	897	19	transcriptome	transcriptome	NN
cord-006702-ekf6mja9	897	20	and	and	CC
cord-006702-ekf6mja9	897	21	proteome	proteome	NN
cord-006702-ekf6mja9	897	22	analysis	analysis	NN
cord-006702-ekf6mja9	897	23	.	.	.
cord-006702-ekf6mja9	898	1	Results	result	NNS
cord-006702-ekf6mja9	898	2	:	:	:
cord-006702-ekf6mja9	899	1	Uremia	Uremia	NNP
cord-006702-ekf6mja9	899	2	induced	induce	VBD
cord-006702-ekf6mja9	899	3	up	up	IN
cord-006702-ekf6mja9	899	4	-	-	HYPH
cord-006702-ekf6mja9	899	5	regulation	regulation	NN
cord-006702-ekf6mja9	899	6	of	of	IN
cord-006702-ekf6mja9	899	7	173	173	CD
cord-006702-ekf6mja9	899	8	and	and	CC
cord-006702-ekf6mja9	899	9	down	down	JJ
cord-006702-ekf6mja9	899	10	-	-	HYPH
cord-006702-ekf6mja9	899	11	regulation	regulation	NN
cord-006702-ekf6mja9	899	12	of	of	IN
cord-006702-ekf6mja9	899	13	117	117	CD
cord-006702-ekf6mja9	899	14	arteriolar	arteriolar	JJ
cord-006702-ekf6mja9	899	15	genes	gene	NNS
cord-006702-ekf6mja9	899	16	(	(	-LRB-
cord-006702-ekf6mja9	899	17	p<0.01	p<0.01	NNP
cord-006702-ekf6mja9	899	18	)	)	-RRB-
cord-006702-ekf6mja9	899	19	compared	compare	VBN
cord-006702-ekf6mja9	899	20	to	to	IN
cord-006702-ekf6mja9	899	21	age	age	NN
cord-006702-ekf6mja9	899	22	and	and	CC
cord-006702-ekf6mja9	899	23	sex	sex	NN
cord-006702-ekf6mja9	899	24	matched	match	VBD
cord-006702-ekf6mja9	899	25	healthy	healthy	JJ
cord-006702-ekf6mja9	899	26	controls	control	NNS
cord-006702-ekf6mja9	899	27	.	.	.
cord-006702-ekf6mja9	900	1	In	in	IN
cord-006702-ekf6mja9	900	2	patients	patient	NNS
cord-006702-ekf6mja9	900	3	on	on	IN
cord-006702-ekf6mja9	900	4	low	low	JJ
cord-006702-ekf6mja9	900	5	GDP	GDP	NNP
cord-006702-ekf6mja9	900	6	PD	PD	NNP
cord-006702-ekf6mja9	900	7	,	,	,
cord-006702-ekf6mja9	900	8	88	88	CD
cord-006702-ekf6mja9	900	9	genes	gene	NNS
cord-006702-ekf6mja9	900	10	were	be	VBD
cord-006702-ekf6mja9	900	11	up	up	RB
cord-006702-ekf6mja9	900	12	-	-	HYPH
cord-006702-ekf6mja9	900	13	and	and	CC
cord-006702-ekf6mja9	900	14	11	11	CD
cord-006702-ekf6mja9	900	15	genes	gene	NNS
cord-006702-ekf6mja9	900	16	down	down	RB
cord-006702-ekf6mja9	900	17	regulated	regulate	VBN
cord-006702-ekf6mja9	900	18	compared	compare	VBN
cord-006702-ekf6mja9	900	19	to	to	IN
cord-006702-ekf6mja9	900	20	respective	respective	JJ
cord-006702-ekf6mja9	900	21	uremic	uremic	JJ
cord-006702-ekf6mja9	900	22	controls	control	NNS
cord-006702-ekf6mja9	900	23	,	,	,
cord-006702-ekf6mja9	900	24	while	while	IN
cord-006702-ekf6mja9	900	25	in	in	IN
cord-006702-ekf6mja9	900	26	children	child	NNS
cord-006702-ekf6mja9	900	27	on	on	IN
cord-006702-ekf6mja9	900	28	high	high	JJ
cord-006702-ekf6mja9	900	29	GPD	gpd	NN
cord-006702-ekf6mja9	900	30	PD	PD	NNP
cord-006702-ekf6mja9	900	31	139	139	CD
cord-006702-ekf6mja9	900	32	genes	gene	NNS
cord-006702-ekf6mja9	900	33	were	be	VBD
cord-006702-ekf6mja9	900	34	up	up	RB
cord-006702-ekf6mja9	900	35	-	-	:
cord-006702-ekf6mja9	900	36	and	and	CC
cord-006702-ekf6mja9	900	37	17	17	CD
cord-006702-ekf6mja9	900	38	genes	gene	NNS
cord-006702-ekf6mja9	900	39	downregulated	downregulate	VBD
cord-006702-ekf6mja9	900	40	.	.	.
cord-006702-ekf6mja9	901	1	Intima	Intima	NNP
cord-006702-ekf6mja9	901	2	media	medium	NNS
cord-006702-ekf6mja9	901	3	thickness	thickness	NN
cord-006702-ekf6mja9	901	4	was	be	VBD
cord-006702-ekf6mja9	901	5	comparable	comparable	JJ
cord-006702-ekf6mja9	901	6	in	in	IN
cord-006702-ekf6mja9	901	7	all	all	DT
cord-006702-ekf6mja9	901	8	groups	group	NNS
cord-006702-ekf6mja9	901	9	.	.	.
cord-006702-ekf6mja9	902	1	Gene	gene	NN
cord-006702-ekf6mja9	902	2	ontology	ontology	NN
cord-006702-ekf6mja9	902	3	analyses	analysis	NNS
cord-006702-ekf6mja9	902	4	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	902	5	activation	activation	NN
cord-006702-ekf6mja9	902	6	of	of	IN
cord-006702-ekf6mja9	902	7	various	various	JJ
cord-006702-ekf6mja9	902	8	inflammatory	inflammatory	JJ
cord-006702-ekf6mja9	902	9	,	,	,
cord-006702-ekf6mja9	902	10	immunological	immunological	JJ
cord-006702-ekf6mja9	902	11	and	and	CC
cord-006702-ekf6mja9	902	12	stress	stress	NN
cord-006702-ekf6mja9	902	13	response	response	NN
cord-006702-ekf6mja9	902	14	cascades	cascade	VBZ
cord-006702-ekf6mja9	902	15	with	with	IN
cord-006702-ekf6mja9	902	16	uremia	uremia	NN
cord-006702-ekf6mja9	902	17	and	and	CC
cord-006702-ekf6mja9	902	18	even	even	RB
cord-006702-ekf6mja9	902	19	more	more	JJR
cord-006702-ekf6mja9	902	20	with	with	IN
cord-006702-ekf6mja9	902	21	PD	PD	NNP
cord-006702-ekf6mja9	902	22	.	.	.
cord-006702-ekf6mja9	903	1	In	in	IN
cord-006702-ekf6mja9	903	2	children	child	NNS
cord-006702-ekf6mja9	903	3	treated	treat	VBN
cord-006702-ekf6mja9	903	4	with	with	IN
cord-006702-ekf6mja9	903	5	low	low	JJ
cord-006702-ekf6mja9	903	6	GDP	gdp	NN
cord-006702-ekf6mja9	903	7	fluid	fluid	NN
cord-006702-ekf6mja9	903	8	the	the	DT
cord-006702-ekf6mja9	903	9	complement	complement	NN
cord-006702-ekf6mja9	903	10	system	system	NN
cord-006702-ekf6mja9	903	11	and	and	CC
cord-006702-ekf6mja9	903	12	respective	respective	JJ
cord-006702-ekf6mja9	903	13	regulatory	regulatory	JJ
cord-006702-ekf6mja9	903	14	pathways	pathway	NNS
cord-006702-ekf6mja9	903	15	were	be	VBD
cord-006702-ekf6mja9	903	16	upregulated	upregulate	VBN
cord-006702-ekf6mja9	903	17	most	most	RBS
cord-006702-ekf6mja9	903	18	significantly	significantly	RB
cord-006702-ekf6mja9	903	19	.	.	.
cord-006702-ekf6mja9	904	1	14	14	CD
cord-006702-ekf6mja9	904	2	complement	complement	NN
cord-006702-ekf6mja9	904	3	factors	factor	NNS
cord-006702-ekf6mja9	904	4	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	904	5	comparable	comparable	JJ
cord-006702-ekf6mja9	904	6	upregulation	upregulation	NN
cord-006702-ekf6mja9	904	7	on	on	IN
cord-006702-ekf6mja9	904	8	RNA	RNA	NNP
cord-006702-ekf6mja9	904	9	and	and	CC
cord-006702-ekf6mja9	904	10	protein	protein	NN
cord-006702-ekf6mja9	904	11	level	level	NN
cord-006702-ekf6mja9	904	12	,	,	,
cord-006702-ekf6mja9	904	13	CD55	CD55	NNP
cord-006702-ekf6mja9	904	14	was	be	VBD
cord-006702-ekf6mja9	904	15	suppressed	suppress	VBN
cord-006702-ekf6mja9	904	16	.	.	.
cord-006702-ekf6mja9	905	1	Findings	finding	NNS
cord-006702-ekf6mja9	905	2	were	be	VBD
cord-006702-ekf6mja9	905	3	validated	validate	VBN
cord-006702-ekf6mja9	905	4	immunohistochemically	immunohistochemically	RB
cord-006702-ekf6mja9	905	5	in	in	IN
cord-006702-ekf6mja9	905	6	an	an	DT
cord-006702-ekf6mja9	905	7	independent	independent	JJ
cord-006702-ekf6mja9	905	8	cohort	cohort	NN
cord-006702-ekf6mja9	905	9	of	of	IN
cord-006702-ekf6mja9	905	10	15	15	CD
cord-006702-ekf6mja9	905	11	children	child	NNS
cord-006702-ekf6mja9	905	12	per	per	IN
cord-006702-ekf6mja9	905	13	group	group	NN
cord-006702-ekf6mja9	905	14	;	;	:
cord-006702-ekf6mja9	905	15	C1q	C1q	NNP
cord-006702-ekf6mja9	905	16	and	and	CC
cord-006702-ekf6mja9	905	17	C3c	C3c	NNP
cord-006702-ekf6mja9	905	18	were	be	VBD
cord-006702-ekf6mja9	905	19	5	5	CD
cord-006702-ekf6mja9	905	20	and	and	CC
cord-006702-ekf6mja9	905	21	2.6	2.6	CD
cord-006702-ekf6mja9	905	22	fold	fold	NN
cord-006702-ekf6mja9	905	23	increased	increase	VBD
cord-006702-ekf6mja9	905	24	with	with	IN
cord-006702-ekf6mja9	905	25	low	low	JJ
cord-006702-ekf6mja9	905	26	GDP	GDP	NNP
cord-006702-ekf6mja9	905	27	PD	PD	NNP
cord-006702-ekf6mja9	905	28	compared	compare	VBN
cord-006702-ekf6mja9	905	29	to	to	IN
cord-006702-ekf6mja9	905	30	uremic	uremic	JJ
cord-006702-ekf6mja9	905	31	controls	control	NNS
cord-006702-ekf6mja9	905	32	.	.	.
cord-006702-ekf6mja9	906	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	906	2	:	:	:
cord-006702-ekf6mja9	907	1	Omental	Omental	NNP
cord-006702-ekf6mja9	907	2	arterioles	arteriole	NNS
cord-006702-ekf6mja9	907	3	are	be	VBP
cord-006702-ekf6mja9	907	4	uniquely	uniquely	RB
cord-006702-ekf6mja9	907	5	suited	suit	VBN
cord-006702-ekf6mja9	907	6	for	for	IN
cord-006702-ekf6mja9	907	7	global	global	JJ
cord-006702-ekf6mja9	907	8	assessment	assessment	NN
cord-006702-ekf6mja9	907	9	of	of	IN
cord-006702-ekf6mja9	907	10	molecular	molecular	JJ
cord-006702-ekf6mja9	907	11	pathomechanisms	pathomechanism	NNS
cord-006702-ekf6mja9	907	12	of	of	IN
cord-006702-ekf6mja9	907	13	uremia	uremia	NN
cord-006702-ekf6mja9	907	14	and	and	CC
cord-006702-ekf6mja9	907	15	PD	PD	NNP
cord-006702-ekf6mja9	907	16	associated	associate	VBD
cord-006702-ekf6mja9	907	17	arteriolopathy	arteriolopathy	NNP
cord-006702-ekf6mja9	907	18	.	.	.
cord-006702-ekf6mja9	908	1	We	-PRON-	PRP
cord-006702-ekf6mja9	908	2	for	for	IN
cord-006702-ekf6mja9	908	3	the	the	DT
cord-006702-ekf6mja9	908	4	first	first	JJ
cord-006702-ekf6mja9	908	5	time	time	NN
cord-006702-ekf6mja9	908	6	demonstrate	demonstrate	VB
cord-006702-ekf6mja9	908	7	specific	specific	JJ
cord-006702-ekf6mja9	908	8	activation	activation	NN
cord-006702-ekf6mja9	908	9	of	of	IN
cord-006702-ekf6mja9	908	10	the	the	DT
cord-006702-ekf6mja9	908	11	complement	complement	NN
cord-006702-ekf6mja9	908	12	cascade	cascade	NN
cord-006702-ekf6mja9	908	13	in	in	IN
cord-006702-ekf6mja9	908	14	arterioles	arteriole	NNS
cord-006702-ekf6mja9	908	15	from	from	IN
cord-006702-ekf6mja9	908	16	children	child	NNS
cord-006702-ekf6mja9	908	17	on	on	IN
cord-006702-ekf6mja9	908	18	low	low	JJ
cord-006702-ekf6mja9	908	19	GDP	GDP	NNP
cord-006702-ekf6mja9	908	20	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	908	21	dialysis	dialysis	NN
cord-006702-ekf6mja9	908	22	,	,	,
cord-006702-ekf6mja9	908	23	prior	prior	RB
cord-006702-ekf6mja9	908	24	to	to	IN
cord-006702-ekf6mja9	908	25	overt	overt	JJ
cord-006702-ekf6mja9	908	26	arteriolopathy	arteriolopathy	NNP
cord-006702-ekf6mja9	908	27	.	.	.
cord-006702-ekf6mja9	909	1	Objectives	objective	NNS
cord-006702-ekf6mja9	909	2	:	:	:
cord-006702-ekf6mja9	909	3	Chronic	chronic	JJ
cord-006702-ekf6mja9	909	4	kidney	kidney	NN
cord-006702-ekf6mja9	909	5	disease	disease	NN
cord-006702-ekf6mja9	909	6	(	(	-LRB-
cord-006702-ekf6mja9	909	7	CKD	CKD	NNP
cord-006702-ekf6mja9	909	8	)	)	-RRB-
cord-006702-ekf6mja9	909	9	is	be	VBZ
cord-006702-ekf6mja9	909	10	a	a	DT
cord-006702-ekf6mja9	909	11	state	state	NN
cord-006702-ekf6mja9	909	12	of	of	IN
cord-006702-ekf6mja9	909	13	Klotho	Klotho	NNP
cord-006702-ekf6mja9	909	14	deficiency	deficiency	NN
cord-006702-ekf6mja9	909	15	and	and	CC
cord-006702-ekf6mja9	909	16	excess	excess	NN
cord-006702-ekf6mja9	909	17	of	of	IN
cord-006702-ekf6mja9	909	18	the	the	DT
cord-006702-ekf6mja9	909	19	phosphaturic	phosphaturic	JJ
cord-006702-ekf6mja9	909	20	hormone	hormone	NN
cord-006702-ekf6mja9	909	21	fibroblast	fibroblast	NN
cord-006702-ekf6mja9	909	22	growth	growth	NN
cord-006702-ekf6mja9	909	23	factor	factor	NN
cord-006702-ekf6mja9	909	24	23	23	CD
cord-006702-ekf6mja9	909	25	(	(	-LRB-
cord-006702-ekf6mja9	909	26	FGF23	fgf23	NN
cord-006702-ekf6mja9	909	27	)	)	-RRB-
cord-006702-ekf6mja9	909	28	.	.	.
cord-006702-ekf6mja9	910	1	Although	although	IN
cord-006702-ekf6mja9	910	2	,	,	,
cord-006702-ekf6mja9	910	3	both	both	DT
cord-006702-ekf6mja9	910	4	findings	finding	NNS
cord-006702-ekf6mja9	910	5	were	be	VBD
cord-006702-ekf6mja9	910	6	shown	show	VBN
cord-006702-ekf6mja9	910	7	to	to	TO
cord-006702-ekf6mja9	910	8	be	be	VB
cord-006702-ekf6mja9	910	9	associated	associate	VBN
cord-006702-ekf6mja9	910	10	with	with	IN
cord-006702-ekf6mja9	910	11	endothelial	endothelial	JJ
cord-006702-ekf6mja9	910	12	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	910	13	in	in	IN
cord-006702-ekf6mja9	910	14	humans	human	NNS
cord-006702-ekf6mja9	910	15	,	,	,
cord-006702-ekf6mja9	910	16	direct	direct	JJ
cord-006702-ekf6mja9	910	17	vascular	vascular	JJ
cord-006702-ekf6mja9	910	18	effects	effect	NNS
cord-006702-ekf6mja9	910	19	of	of	IN
cord-006702-ekf6mja9	910	20	FGF23	fgf23	NN
cord-006702-ekf6mja9	910	21	remain	remain	VBP
cord-006702-ekf6mja9	910	22	largely	largely	RB
cord-006702-ekf6mja9	910	23	elusive	elusive	JJ
cord-006702-ekf6mja9	910	24	.	.	.
cord-006702-ekf6mja9	911	1	Here	here	RB
cord-006702-ekf6mja9	911	2	,	,	,
cord-006702-ekf6mja9	911	3	we	-PRON-	PRP
cord-006702-ekf6mja9	911	4	investigated	investigate	VBD
cord-006702-ekf6mja9	911	5	the	the	DT
cord-006702-ekf6mja9	911	6	effects	effect	NNS
cord-006702-ekf6mja9	911	7	of	of	IN
cord-006702-ekf6mja9	911	8	FGF23	fgf23	NN
cord-006702-ekf6mja9	911	9	in	in	IN
cord-006702-ekf6mja9	911	10	relation	relation	NN
cord-006702-ekf6mja9	911	11	to	to	IN
cord-006702-ekf6mja9	911	12	its	-PRON-	PRP$
cord-006702-ekf6mja9	911	13	coreceptor	coreceptor	NN
cord-006702-ekf6mja9	911	14	Klotho	Klotho	NNP
cord-006702-ekf6mja9	911	15	on	on	IN
cord-006702-ekf6mja9	911	16	nitric	nitric	JJ
cord-006702-ekf6mja9	911	17	oxide	oxide	NN
cord-006702-ekf6mja9	912	1	(	(	-LRB-
cord-006702-ekf6mja9	912	2	NO	no	DT
cord-006702-ekf6mja9	912	3	)	)	-RRB-
cord-006702-ekf6mja9	912	4	synthesis	synthesis	NN
cord-006702-ekf6mja9	912	5	and	and	CC
cord-006702-ekf6mja9	912	6	reactive	reactive	JJ
cord-006702-ekf6mja9	912	7	oxygen	oxygen	NN
cord-006702-ekf6mja9	912	8	species	specie	NNS
cord-006702-ekf6mja9	912	9	(	(	-LRB-
cord-006702-ekf6mja9	912	10	ROS	ROS	NNP
cord-006702-ekf6mja9	912	11	)	)	-RRB-
cord-006702-ekf6mja9	912	12	formation	formation	NN
cord-006702-ekf6mja9	912	13	and	and	CC
cord-006702-ekf6mja9	912	14	detoxification	detoxification	NN
cord-006702-ekf6mja9	912	15	in	in	IN
cord-006702-ekf6mja9	912	16	human	human	JJ
cord-006702-ekf6mja9	912	17	coronary	coronary	JJ
cord-006702-ekf6mja9	912	18	artery	artery	NN
cord-006702-ekf6mja9	912	19	endothelial	endothelial	JJ
cord-006702-ekf6mja9	912	20	cells	cell	NNS
cord-006702-ekf6mja9	912	21	(	(	-LRB-
cord-006702-ekf6mja9	912	22	HCAEC	HCAEC	NNP
cord-006702-ekf6mja9	912	23	)	)	-RRB-
cord-006702-ekf6mja9	912	24	in	in	IN
cord-006702-ekf6mja9	912	25	vitro	vitro	FW
cord-006702-ekf6mja9	912	26	.	.	.
cord-006702-ekf6mja9	913	1	Methods	method	NNS
cord-006702-ekf6mja9	913	2	:	:	:
cord-006702-ekf6mja9	914	1	HCAEC	HCAEC	NNP
cord-006702-ekf6mja9	914	2	were	be	VBD
cord-006702-ekf6mja9	914	3	stimulated	stimulate	VBN
cord-006702-ekf6mja9	914	4	with	with	IN
cord-006702-ekf6mja9	914	5	FGF23	fgf23	NN
cord-006702-ekf6mja9	914	6	(	(	-LRB-
cord-006702-ekf6mja9	914	7	10	10	CD
cord-006702-ekf6mja9	914	8	ng	ng	NN
cord-006702-ekf6mja9	914	9	/	/	SYM
cord-006702-ekf6mja9	914	10	mL	mL	NNP
cord-006702-ekf6mja9	914	11	)	)	-RRB-
cord-006702-ekf6mja9	914	12	in	in	IN
cord-006702-ekf6mja9	914	13	the	the	DT
cord-006702-ekf6mja9	914	14	presence	presence	NN
cord-006702-ekf6mja9	914	15	or	or	CC
cord-006702-ekf6mja9	914	16	absence	absence	NN
cord-006702-ekf6mja9	914	17	of	of	IN
cord-006702-ekf6mja9	914	18	a	a	DT
cord-006702-ekf6mja9	914	19	pan	pan	JJ
cord-006702-ekf6mja9	914	20	-	-	JJ
cord-006702-ekf6mja9	914	21	FGF	FGF	NNP
cord-006702-ekf6mja9	914	22	receptor	receptor	NN
cord-006702-ekf6mja9	914	23	(	(	-LRB-
cord-006702-ekf6mja9	914	24	FGFR	FGFR	NNP
cord-006702-ekf6mja9	914	25	)	)	-RRB-
cord-006702-ekf6mja9	914	26	or	or	CC
cord-006702-ekf6mja9	914	27	Klotho	Klotho	NNP
cord-006702-ekf6mja9	914	28	inhibitor	inhibitor	NN
cord-006702-ekf6mja9	914	29	,	,	,
cord-006702-ekf6mja9	914	30	and	and	CC
cord-006702-ekf6mja9	914	31	investigated	investigate	VBN
cord-006702-ekf6mja9	914	32	by	by	IN
cord-006702-ekf6mja9	914	33	quantitative	quantitative	JJ
cord-006702-ekf6mja9	914	34	real	real	JJ
cord-006702-ekf6mja9	914	35	-	-	HYPH
cord-006702-ekf6mja9	914	36	time	time	NN
cord-006702-ekf6mja9	914	37	PCR	PCR	NNP
cord-006702-ekf6mja9	914	38	,	,	,
cord-006702-ekf6mja9	914	39	immunoblotting	immunoblotting	NN
cord-006702-ekf6mja9	914	40	,	,	,
cord-006702-ekf6mja9	914	41	and	and	CC
cord-006702-ekf6mja9	914	42	flow	flow	VB
cord-006702-ekf6mja9	914	43	cytometry	cytometry	NN
cord-006702-ekf6mja9	914	44	.	.	.
cord-006702-ekf6mja9	915	1	Results	result	NNS
cord-006702-ekf6mja9	915	2	:	:	:
cord-006702-ekf6mja9	916	1	HCAEC	HCAEC	NNP
cord-006702-ekf6mja9	916	2	express	express	VBP
cord-006702-ekf6mja9	916	3	FGFRs	fgfr	NNS
cord-006702-ekf6mja9	916	4	and	and	CC
cord-006702-ekf6mja9	916	5	membrane	membrane	NN
cord-006702-ekf6mja9	916	6	-	-	HYPH
cord-006702-ekf6mja9	916	7	bound	bind	VBN
cord-006702-ekf6mja9	916	8	Klotho	Klotho	NNP
cord-006702-ekf6mja9	916	9	.	.	.
cord-006702-ekf6mja9	917	1	FGF23	fgf23	NN
cord-006702-ekf6mja9	917	2	increases	increase	VBZ
cord-006702-ekf6mja9	917	3	the	the	DT
cord-006702-ekf6mja9	917	4	expression	expression	NN
cord-006702-ekf6mja9	917	5	of	of	IN
cord-006702-ekf6mja9	917	6	the	the	DT
cord-006702-ekf6mja9	917	7	Klotho	Klotho	NNP
cord-006702-ekf6mja9	917	8	shedding	shed	VBG
cord-006702-ekf6mja9	917	9	protease	protease	NN
cord-006702-ekf6mja9	917	10	ADAM17	adam17	NN
cord-006702-ekf6mja9	917	11	and	and	CC
cord-006702-ekf6mja9	917	12	consequently	consequently	RB
cord-006702-ekf6mja9	917	13	the	the	DT
cord-006702-ekf6mja9	917	14	secretion	secretion	NN
cord-006702-ekf6mja9	917	15	of	of	IN
cord-006702-ekf6mja9	917	16	soluble	soluble	JJ
cord-006702-ekf6mja9	917	17	Klotho	Klotho	NNP
cord-006702-ekf6mja9	917	18	.	.	.
cord-006702-ekf6mja9	918	1	FGF23	fgf23	NN
cord-006702-ekf6mja9	918	2	activates	activate	VBZ
cord-006702-ekf6mja9	918	3	FGFR1	FGFR1	NNP
cord-006702-ekf6mja9	918	4	,	,	,
cord-006702-ekf6mja9	918	5	and	and	CC
cord-006702-ekf6mja9	918	6	stimulates	stimulate	VBZ
cord-006702-ekf6mja9	918	7	NO	no	DT
cord-006702-ekf6mja9	918	8	release	release	NN
cord-006702-ekf6mja9	918	9	via	via	IN
cord-006702-ekf6mja9	918	10	Akt	Akt	NNP
cord-006702-ekf6mja9	918	11	-	-	HYPH
cord-006702-ekf6mja9	918	12	dependent	dependent	JJ
cord-006702-ekf6mja9	918	13	activation	activation	NN
cord-006702-ekf6mja9	918	14	of	of	IN
cord-006702-ekf6mja9	918	15	endothelial	endothelial	JJ
cord-006702-ekf6mja9	918	16	NO	no	DT
cord-006702-ekf6mja9	918	17	synthase	synthase	NN
cord-006702-ekf6mja9	918	18	(	(	-LRB-
cord-006702-ekf6mja9	918	19	eNOS	enos	NN
cord-006702-ekf6mja9	918	20	)	)	-RRB-
cord-006702-ekf6mja9	918	21	.	.	.
cord-006702-ekf6mja9	919	1	Both	both	DT
cord-006702-ekf6mja9	919	2	,	,	,
cord-006702-ekf6mja9	919	3	ROS	ROS	NNP
cord-006702-ekf6mja9	919	4	formation	formation	NN
cord-006702-ekf6mja9	919	5	via	via	IN
cord-006702-ekf6mja9	919	6	NADPH	NADPH	NNP
cord-006702-ekf6mja9	919	7	oxidase	oxidase	NN
cord-006702-ekf6mja9	919	8	2	2	CD
cord-006702-ekf6mja9	920	1	(	(	-LRB-
cord-006702-ekf6mja9	920	2	Nox2	Nox2	NNP
cord-006702-ekf6mja9	920	3	)	)	-RRB-
cord-006702-ekf6mja9	920	4	as	as	RB
cord-006702-ekf6mja9	920	5	well	well	RB
cord-006702-ekf6mja9	920	6	as	as	IN
cord-006702-ekf6mja9	920	7	ROS	ROS	NNP
cord-006702-ekf6mja9	920	8	degradation	degradation	NN
cord-006702-ekf6mja9	920	9	via	via	IN
cord-006702-ekf6mja9	920	10	superoxide	superoxide	NN
cord-006702-ekf6mja9	920	11	dismutase	dismutase	NN
cord-006702-ekf6mja9	920	12	2	2	CD
cord-006702-ekf6mja9	920	13	(	(	-LRB-
cord-006702-ekf6mja9	920	14	SOD2	SOD2	NNP
cord-006702-ekf6mja9	920	15	)	)	-RRB-
cord-006702-ekf6mja9	920	16	and	and	CC
cord-006702-ekf6mja9	920	17	catalase	catalase	NN
cord-006702-ekf6mja9	920	18	(	(	-LRB-
cord-006702-ekf6mja9	920	19	CAT	cat	NN
cord-006702-ekf6mja9	920	20	)	)	-RRB-
cord-006702-ekf6mja9	920	21	are	be	VBP
cord-006702-ekf6mja9	920	22	stimulated	stimulate	VBN
cord-006702-ekf6mja9	920	23	by	by	IN
cord-006702-ekf6mja9	920	24	FGF23	fgf23	NN
cord-006702-ekf6mja9	920	25	treatment	treatment	NN
cord-006702-ekf6mja9	920	26	.	.	.
cord-006702-ekf6mja9	921	1	The	the	DT
cord-006702-ekf6mja9	921	2	effects	effect	NNS
cord-006702-ekf6mja9	921	3	of	of	IN
cord-006702-ekf6mja9	921	4	FGF23	fgf23	NN
cord-006702-ekf6mja9	921	5	on	on	IN
cord-006702-ekf6mja9	921	6	NO	no	DT
cord-006702-ekf6mja9	921	7	synthesis	synthesis	NN
cord-006702-ekf6mja9	921	8	as	as	RB
cord-006702-ekf6mja9	921	9	well	well	RB
cord-006702-ekf6mja9	921	10	as	as	IN
cord-006702-ekf6mja9	921	11	on	on	IN
cord-006702-ekf6mja9	921	12	ROS	ROS	NNP
cord-006702-ekf6mja9	921	13	formation	formation	NN
cord-006702-ekf6mja9	921	14	and	and	CC
cord-006702-ekf6mja9	921	15	degradation	degradation	NN
cord-006702-ekf6mja9	921	16	are	be	VBP
cord-006702-ekf6mja9	921	17	FGFR	FGFR	NNP
cord-006702-ekf6mja9	921	18	-	-	HYPH
cord-006702-ekf6mja9	921	19	dependent	dependent	JJ
cord-006702-ekf6mja9	921	20	.	.	.
cord-006702-ekf6mja9	922	1	Pre	pre	JJ
cord-006702-ekf6mja9	922	2	-	-	NN
cord-006702-ekf6mja9	922	3	incubation	incubation	NN
cord-006702-ekf6mja9	922	4	with	with	IN
cord-006702-ekf6mja9	922	5	a	a	DT
cord-006702-ekf6mja9	922	6	Klotho	Klotho	NNP
cord-006702-ekf6mja9	922	7	inhibitor	inhibitor	NN
cord-006702-ekf6mja9	922	8	blunts	blunt	VBZ
cord-006702-ekf6mja9	922	9	the	the	DT
cord-006702-ekf6mja9	922	10	FGF23-stimulated	FGF23-stimulated	NNP
cord-006702-ekf6mja9	922	11	Akt	Akt	NNP
cord-006702-ekf6mja9	922	12	-	-	HYPH
cord-006702-ekf6mja9	922	13	eNOS	enos	JJ
cord-006702-ekf6mja9	922	14	activation	activation	NN
cord-006702-ekf6mja9	922	15	and	and	CC
cord-006702-ekf6mja9	922	16	NO	no	DT
cord-006702-ekf6mja9	922	17	synthesis	synthesis	NN
cord-006702-ekf6mja9	922	18	,	,	,
cord-006702-ekf6mja9	922	19	decreases	decrease	VBZ
cord-006702-ekf6mja9	922	20	ROS	ROS	NNP
cord-006702-ekf6mja9	922	21	degradation	degradation	NN
cord-006702-ekf6mja9	922	22	by	by	IN
cord-006702-ekf6mja9	922	23	blocking	block	VBG
cord-006702-ekf6mja9	922	24	SOD2	SOD2	NNP
cord-006702-ekf6mja9	922	25	and	and	CC
cord-006702-ekf6mja9	922	26	CAT	cat	NN
cord-006702-ekf6mja9	922	27	enzymes	enzyme	NNS
cord-006702-ekf6mja9	922	28	,	,	,
cord-006702-ekf6mja9	922	29	whereas	whereas	IN
cord-006702-ekf6mja9	922	30	FGF23-stimulated	fgf23-stimulated	CD
cord-006702-ekf6mja9	922	31	ROS	ROS	NNP
cord-006702-ekf6mja9	922	32	synthesis	synthesis	NN
cord-006702-ekf6mja9	922	33	via	via	IN
cord-006702-ekf6mja9	922	34	Nox2	Nox2	NNS
cord-006702-ekf6mja9	922	35	is	be	VBZ
cord-006702-ekf6mja9	922	36	unaffected	unaffected	JJ
cord-006702-ekf6mja9	922	37	,	,	,
cord-006702-ekf6mja9	922	38	resulting	result	VBG
cord-006702-ekf6mja9	922	39	in	in	IN
cord-006702-ekf6mja9	922	40	low	low	JJ
cord-006702-ekf6mja9	922	41	NO	no	DT
cord-006702-ekf6mja9	922	42	bioavailability	bioavailability	NN
cord-006702-ekf6mja9	922	43	and	and	CC
cord-006702-ekf6mja9	922	44	increased	increase	VBN
cord-006702-ekf6mja9	922	45	oxidative	oxidative	JJ
cord-006702-ekf6mja9	922	46	stress	stress	NN
cord-006702-ekf6mja9	922	47	.	.	.
cord-006702-ekf6mja9	923	1	In	in	IN
cord-006702-ekf6mja9	923	2	the	the	DT
cord-006702-ekf6mja9	923	3	presence	presence	NN
cord-006702-ekf6mja9	923	4	of	of	IN
cord-006702-ekf6mja9	923	5	Klotho	Klotho	NNP
cord-006702-ekf6mja9	923	6	,	,	,
cord-006702-ekf6mja9	923	7	FGF23	FGF23	NNP
cord-006702-ekf6mja9	923	8	induces	induce	VBZ
cord-006702-ekf6mja9	923	9	NO	no	DT
cord-006702-ekf6mja9	923	10	release	release	NN
cord-006702-ekf6mja9	923	11	in	in	IN
cord-006702-ekf6mja9	923	12	HCAEC	HCAEC	NNP
cord-006702-ekf6mja9	923	13	and	and	CC
cord-006702-ekf6mja9	923	14	its	-PRON-	PRP$
cord-006702-ekf6mja9	923	15	stimulating	stimulating	JJ
cord-006702-ekf6mja9	923	16	effects	effect	NNS
cord-006702-ekf6mja9	923	17	on	on	IN
cord-006702-ekf6mja9	923	18	ROS	ROS	NNP
cord-006702-ekf6mja9	923	19	production	production	NN
cord-006702-ekf6mja9	923	20	are	be	VBP
cord-006702-ekf6mja9	923	21	counterbalanced	counterbalance	VBN
cord-006702-ekf6mja9	923	22	by	by	IN
cord-006702-ekf6mja9	923	23	increased	increase	VBN
cord-006702-ekf6mja9	923	24	ROS	ROS	NNP
cord-006702-ekf6mja9	923	25	degradation	degradation	NN
cord-006702-ekf6mja9	923	26	.	.	.
cord-006702-ekf6mja9	924	1	In	in	IN
cord-006702-ekf6mja9	924	2	the	the	DT
cord-006702-ekf6mja9	924	3	absence	absence	NN
cord-006702-ekf6mja9	924	4	ofKlotho	ofKlotho	NNP
cord-006702-ekf6mja9	924	5	,	,	,
cord-006702-ekf6mja9	924	6	FGF23-mediated	fgf23-mediated	JJ
cord-006702-ekf6mja9	924	7	NO	no	DT
cord-006702-ekf6mja9	924	8	synthesis	synthesis	NN
cord-006702-ekf6mja9	924	9	is	be	VBZ
cord-006702-ekf6mja9	924	10	blunted	blunt	VBN
cord-006702-ekf6mja9	924	11	and	and	CC
cord-006702-ekf6mja9	924	12	ROS	ROS	NNP
cord-006702-ekf6mja9	924	13	formation	formation	NN
cord-006702-ekf6mja9	924	14	overrules	overrule	VBZ
cord-006702-ekf6mja9	924	15	ROS	ROS	NNP
cord-006702-ekf6mja9	924	16	degradation	degradation	NN
cord-006702-ekf6mja9	924	17	.	.	.
cord-006702-ekf6mja9	925	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	925	2	results	result	NNS
cord-006702-ekf6mja9	925	3	suggest	suggest	VBP
cord-006702-ekf6mja9	925	4	that	that	IN
cord-006702-ekf6mja9	925	5	in	in	IN
cord-006702-ekf6mja9	925	6	states	state	NNS
cord-006702-ekf6mja9	925	7	of	of	IN
cord-006702-ekf6mja9	925	8	Klotho	Klotho	NNP
cord-006702-ekf6mja9	925	9	deficiency	deficiency	NN
cord-006702-ekf6mja9	925	10	,	,	,
cord-006702-ekf6mja9	925	11	e.g.	e.g.	RB
cord-006702-ekf6mja9	925	12	CKD	CKD	NNP
cord-006702-ekf6mja9	925	13	,	,	,
cord-006702-ekf6mja9	925	14	FGF23	FGF23	NNP
cord-006702-ekf6mja9	925	15	excess	excess	NN
cord-006702-ekf6mja9	925	16	may	may	MD
cord-006702-ekf6mja9	925	17	primarily	primarily	RB
cord-006702-ekf6mja9	925	18	promote	promote	VB
cord-006702-ekf6mja9	925	19	oxidative	oxidative	JJ
cord-006702-ekf6mja9	925	20	stress	stress	NN
cord-006702-ekf6mja9	925	21	and	and	CC
cord-006702-ekf6mja9	925	22	thus	thus	RB
cord-006702-ekf6mja9	925	23	endothelial	endothelial	JJ
cord-006702-ekf6mja9	925	24	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	925	25	.	.	.
cord-006702-ekf6mja9	926	1	FP	FP	NNP
cord-006702-ekf6mja9	926	2	-	-	HYPH
cord-006702-ekf6mja9	926	3	S25	S25	NNP
cord-006702-ekf6mja9	926	4	-	-	HYPH
cord-006702-ekf6mja9	926	5	04	04	CD
cord-006702-ekf6mja9	926	6	Dysregulation	Dysregulation	NNP
cord-006702-ekf6mja9	926	7	of	of	IN
cord-006702-ekf6mja9	926	8	hepatic	hepatic	JJ
cord-006702-ekf6mja9	926	9	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	926	10	transporter	transporter	NN
cord-006702-ekf6mja9	926	11	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	926	12	in	in	IN
cord-006702-ekf6mja9	926	13	IL13-induced	il13-induced	CD
cord-006702-ekf6mja9	926	14	hypercholesterolemia	hypercholesterolemia	NN
cord-006702-ekf6mja9	926	15	in	in	IN
cord-006702-ekf6mja9	926	16	a	a	DT
cord-006702-ekf6mja9	926	17	rat	rat	NN
cord-006702-ekf6mja9	926	18	model	model	NN
cord-006702-ekf6mja9	926	19	of	of	IN
cord-006702-ekf6mja9	926	20	minimal	minimal	JJ
cord-006702-ekf6mja9	926	21	change	change	NN
cord-006702-ekf6mja9	926	22	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	926	23	syndrome	syndrome	NN
cord-006702-ekf6mja9	926	24	(	(	-LRB-
cord-006702-ekf6mja9	926	25	MCNS	MCNS	NNP
cord-006702-ekf6mja9	926	26	)	)	-RRB-
cord-006702-ekf6mja9	927	1	C.Y.	C.Y.	NNP
cord-006702-ekf6mja9	927	2	Chan	Chan	NNP
cord-006702-ekf6mja9	927	3	(	(	-LRB-
cord-006702-ekf6mja9	927	4	1	1	CD
cord-006702-ekf6mja9	927	5	)	)	-RRB-
cord-006702-ekf6mja9	927	6	,	,	,
cord-006702-ekf6mja9	927	7	L.D.	L.D.	NNP
cord-006702-ekf6mja9	927	8	Low	Low	NNP
cord-006702-ekf6mja9	927	9	(	(	-LRB-
cord-006702-ekf6mja9	927	10	1	1	CD
cord-006702-ekf6mja9	927	11	)	)	-RRB-
cord-006702-ekf6mja9	927	12	,	,	,
cord-006702-ekf6mja9	927	13	J.	J.	NNP
cord-006702-ekf6mja9	927	14	Chen	Chen	NNP
cord-006702-ekf6mja9	927	15	(	(	-LRB-
cord-006702-ekf6mja9	927	16	2	2	CD
cord-006702-ekf6mja9	927	17	)	)	-RRB-
cord-006702-ekf6mja9	927	18	,	,	,
cord-006702-ekf6mja9	927	19	K	K	NNP
cord-006702-ekf6mja9	927	20	-	-	HYPH
cord-006702-ekf6mja9	927	21	H.	H.	NNP
cord-006702-ekf6mja9	927	22	Ng	Ng	NNP
cord-006702-ekf6mja9	927	23	(	(	-LRB-
cord-006702-ekf6mja9	927	24	1	1	CD
cord-006702-ekf6mja9	927	25	)	)	-RRB-
cord-006702-ekf6mja9	927	26	,	,	,
cord-006702-ekf6mja9	927	27	H.H.	H.H.	NNP
cord-006702-ekf6mja9	927	28	Yang	Yang	NNP
cord-006702-ekf6mja9	927	29	(	(	-LRB-
cord-006702-ekf6mja9	927	30	1	1	CD
cord-006702-ekf6mja9	927	31	)	)	-RRB-
cord-006702-ekf6mja9	927	32	,	,	,
cord-006702-ekf6mja9	927	33	H.	H.	NNP
cord-006702-ekf6mja9	927	34	Yu	Yu	NNP
cord-006702-ekf6mja9	927	35	(	(	-LRB-
cord-006702-ekf6mja9	927	36	1	1	CD
cord-006702-ekf6mja9	927	37	)	)	-RRB-
cord-006702-ekf6mja9	927	38	,	,	.
cord-006702-ekf6mja9	928	1	M.R.	M.R.	NNP
cord-006702-ekf6mja9	928	2	Wenk	Wenk	NNP
cord-006702-ekf6mja9	928	3	(	(	-LRB-
cord-006702-ekf6mja9	928	4	1	1	CD
cord-006702-ekf6mja9	928	5	)	)	-RRB-
cord-006702-ekf6mja9	928	6	,	,	,
cord-006702-ekf6mja9	928	7	H	H	NNP
cord-006702-ekf6mja9	928	8	-	-	HYPH
cord-006702-ekf6mja9	928	9	K.	K.	NNP
cord-006702-ekf6mja9	928	10	Yap	Yap	NNP
cord-006702-ekf6mja9	928	11	(	(	-LRB-
cord-006702-ekf6mja9	928	12	1	1	CD
cord-006702-ekf6mja9	928	13	)	)	-RRB-
cord-006702-ekf6mja9	928	14	(	(	-LRB-
cord-006702-ekf6mja9	928	15	1	1	LS
cord-006702-ekf6mja9	928	16	)	)	-RRB-
cord-006702-ekf6mja9	928	17	National	National	NNP
cord-006702-ekf6mja9	928	18	University	University	NNP
cord-006702-ekf6mja9	928	19	of	of	IN
cord-006702-ekf6mja9	928	20	Singapore	Singapore	NNP
cord-006702-ekf6mja9	928	21	,	,	,
cord-006702-ekf6mja9	928	22	Singapore	Singapore	NNP
cord-006702-ekf6mja9	928	23	,	,	,
cord-006702-ekf6mja9	928	24	Singapore	Singapore	NNP
cord-006702-ekf6mja9	928	25	;	;	:
cord-006702-ekf6mja9	928	26	(	(	-LRB-
cord-006702-ekf6mja9	928	27	2	2	LS
cord-006702-ekf6mja9	928	28	)	)	-RRB-
cord-006702-ekf6mja9	928	29	Agency	Agency	NNP
cord-006702-ekf6mja9	928	30	for	for	IN
cord-006702-ekf6mja9	928	31	Science	Science	NNP
cord-006702-ekf6mja9	928	32	,	,	,
cord-006702-ekf6mja9	928	33	Technology	Technology	NNP
cord-006702-ekf6mja9	928	34	and	and	CC
cord-006702-ekf6mja9	928	35	Research	Research	NNP
cord-006702-ekf6mja9	928	36	(	(	-LRB-
cord-006702-ekf6mja9	928	37	A*STAR	A*STAR	NNP
cord-006702-ekf6mja9	928	38	)	)	-RRB-
cord-006702-ekf6mja9	928	39	,	,	,
cord-006702-ekf6mja9	928	40	Singapore	Singapore	NNP
cord-006702-ekf6mja9	928	41	,	,	,
cord-006702-ekf6mja9	929	1	Singapore	Singapore	NNP
cord-006702-ekf6mja9	929	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	929	3	:	:	:
cord-006702-ekf6mja9	930	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	930	2	IL13	IL13	NNP
cord-006702-ekf6mja9	930	3	gene	gene	NN
cord-006702-ekf6mja9	930	4	overexpression	overexpression	NN
cord-006702-ekf6mja9	930	5	rat	rat	NN
cord-006702-ekf6mja9	930	6	model	model	NN
cord-006702-ekf6mja9	930	7	of	of	IN
cord-006702-ekf6mja9	930	8	MCNS	MCNS	NNP
cord-006702-ekf6mja9	930	9	showed	show	VBD
cord-006702-ekf6mja9	930	10	that	that	IN
cord-006702-ekf6mja9	930	11	hypercholesterolemia	hypercholesterolemia	NN
cord-006702-ekf6mja9	930	12	correlated	correlate	VBD
cord-006702-ekf6mja9	930	13	significantly	significantly	RB
cord-006702-ekf6mja9	930	14	with	with	IN
cord-006702-ekf6mja9	930	15	serum	serum	NN
cord-006702-ekf6mja9	930	16	IL13	IL13	NNP
cord-006702-ekf6mja9	930	17	,	,	,
cord-006702-ekf6mja9	930	18	and	and	CC
cord-006702-ekf6mja9	930	19	appeared	appear	VBD
cord-006702-ekf6mja9	930	20	to	to	TO
cord-006702-ekf6mja9	930	21	precede	precede	VB
cord-006702-ekf6mja9	930	22	the	the	DT
cord-006702-ekf6mja9	930	23	development	development	NN
cord-006702-ekf6mja9	930	24	of	of	IN
cord-006702-ekf6mja9	930	25	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	930	26	.	.	.
cord-006702-ekf6mja9	931	1	This	this	DT
cord-006702-ekf6mja9	931	2	study	study	NN
cord-006702-ekf6mja9	931	3	aimed	aim	VBD
cord-006702-ekf6mja9	931	4	to	to	TO
cord-006702-ekf6mja9	931	5	investigate	investigate	VB
cord-006702-ekf6mja9	931	6	the	the	DT
cord-006702-ekf6mja9	931	7	mechanism	mechanism	NN
cord-006702-ekf6mja9	931	8	of	of	IN
cord-006702-ekf6mja9	931	9	IL13-induced	il13-induced	CD
cord-006702-ekf6mja9	931	10	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	931	11	dysregulation	dysregulation	NN
cord-006702-ekf6mja9	931	12	in	in	IN
cord-006702-ekf6mja9	931	13	our	-PRON-	PRP$
cord-006702-ekf6mja9	931	14	rat	rat	NN
cord-006702-ekf6mja9	931	15	model	model	NN
cord-006702-ekf6mja9	931	16	of	of	IN
cord-006702-ekf6mja9	931	17	MCNS	MCNS	NNP
cord-006702-ekf6mja9	931	18	.	.	.
cord-006702-ekf6mja9	932	1	Methods	method	NNS
cord-006702-ekf6mja9	932	2	:	:	:
cord-006702-ekf6mja9	932	3	Hepatic	hepatic	JJ
cord-006702-ekf6mja9	932	4	transcriptome	transcriptome	NN
cord-006702-ekf6mja9	932	5	of	of	IN
cord-006702-ekf6mja9	932	6	IL13-transfected	il13-transfected	JJ
cord-006702-ekf6mja9	932	7	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	932	8	rats	rat	NNS
cord-006702-ekf6mja9	932	9	(	(	-LRB-
cord-006702-ekf6mja9	932	10	late	late	JJ
cord-006702-ekf6mja9	932	11	event	event	NN
cord-006702-ekf6mja9	932	12	)	)	-RRB-
cord-006702-ekf6mja9	932	13	was	be	VBD
cord-006702-ekf6mja9	932	14	studied	study	VBN
cord-006702-ekf6mja9	932	15	using	use	VBG
cord-006702-ekf6mja9	932	16	microarray	microarray	NN
cord-006702-ekf6mja9	932	17	and	and	CC
cord-006702-ekf6mja9	932	18	qPCR	qpcr	NN
cord-006702-ekf6mja9	932	19	.	.	.
cord-006702-ekf6mja9	933	1	This	this	DT
cord-006702-ekf6mja9	933	2	was	be	VBD
cord-006702-ekf6mja9	933	3	compared	compare	VBN
cord-006702-ekf6mja9	933	4	with	with	IN
cord-006702-ekf6mja9	933	5	the	the	DT
cord-006702-ekf6mja9	933	6	gene	gene	NN
cord-006702-ekf6mja9	933	7	expression	expression	NN
cord-006702-ekf6mja9	933	8	profile	profile	NN
cord-006702-ekf6mja9	933	9	of	of	IN
cord-006702-ekf6mja9	933	10	hepatic	hepatic	JJ
cord-006702-ekf6mja9	933	11	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	933	12	metabolism	metabolism	NN
cord-006702-ekf6mja9	933	13	at	at	IN
cord-006702-ekf6mja9	933	14	the	the	DT
cord-006702-ekf6mja9	933	15	onset	onset	NN
cord-006702-ekf6mja9	933	16	of	of	IN
cord-006702-ekf6mja9	933	17	hypercholesterolemia	hypercholesterolemia	NN
cord-006702-ekf6mja9	933	18	in	in	IN
cord-006702-ekf6mja9	933	19	the	the	DT
cord-006702-ekf6mja9	933	20	pre	pre	JJ
cord-006702-ekf6mja9	933	21	-	-	JJ
cord-006702-ekf6mja9	933	22	proteinuric	proteinuric	JJ
cord-006702-ekf6mja9	933	23	phase	phase	NN
cord-006702-ekf6mja9	933	24	(	(	-LRB-
cord-006702-ekf6mja9	933	25	early	early	JJ
cord-006702-ekf6mja9	933	26	event	event	NN
cord-006702-ekf6mja9	933	27	,	,	,
cord-006702-ekf6mja9	933	28	HC	HC	NNP
cord-006702-ekf6mja9	933	29	rats	rat	NNS
cord-006702-ekf6mja9	933	30	)	)	-RRB-
cord-006702-ekf6mja9	933	31	.	.	.
cord-006702-ekf6mja9	934	1	IL13-mediated	il13-mediated	JJ
cord-006702-ekf6mja9	934	2	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	934	3	effluxes	effluxes	RB
cord-006702-ekf6mja9	934	4	via	via	IN
cord-006702-ekf6mja9	934	5	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	935	1	and	and	CC
cord-006702-ekf6mja9	935	2	ABCA1	ABCA1	NNP
cord-006702-ekf6mja9	935	3	were	be	VBD
cord-006702-ekf6mja9	935	4	measured	measure	VBN
cord-006702-ekf6mja9	935	5	using	use	VBG
cord-006702-ekf6mja9	935	6	taurocholate	taurocholate	NNP
cord-006702-ekf6mja9	935	7	and	and	CC
cord-006702-ekf6mja9	935	8	apoAI	apoAI	NNP
cord-006702-ekf6mja9	935	9	as	as	IN
cord-006702-ekf6mja9	935	10	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	935	11	acceptors	acceptor	NNS
cord-006702-ekf6mja9	935	12	respectively	respectively	RB
cord-006702-ekf6mja9	935	13	in	in	IN
cord-006702-ekf6mja9	935	14	rat	rat	NN
cord-006702-ekf6mja9	935	15	primary	primary	JJ
cord-006702-ekf6mja9	935	16	hepatocytes	hepatocyte	NNS
cord-006702-ekf6mja9	935	17	.	.	.
cord-006702-ekf6mja9	936	1	The	the	DT
cord-006702-ekf6mja9	936	2	role	role	NN
cord-006702-ekf6mja9	936	3	of	of	IN
cord-006702-ekf6mja9	936	4	LXRa	LXRa	NNS
cord-006702-ekf6mja9	936	5	was	be	VBD
cord-006702-ekf6mja9	936	6	validated	validate	VBN
cord-006702-ekf6mja9	936	7	using	use	VBG
cord-006702-ekf6mja9	936	8	luciferase	luciferase	JJ
cord-006702-ekf6mja9	936	9	assay	assay	NN
cord-006702-ekf6mja9	936	10	.	.	.
cord-006702-ekf6mja9	937	1	Results	result	NNS
cord-006702-ekf6mja9	937	2	:	:	:
cord-006702-ekf6mja9	937	3	'	'	''
cord-006702-ekf6mja9	937	4	ABC	ABC	NNP
cord-006702-ekf6mja9	937	5	transporters	transporter	NNS
cord-006702-ekf6mja9	937	6	'	'	''
cord-006702-ekf6mja9	937	7	was	be	VBD
cord-006702-ekf6mja9	937	8	identified	identify	VBN
cord-006702-ekf6mja9	937	9	as	as	IN
cord-006702-ekf6mja9	937	10	the	the	DT
cord-006702-ekf6mja9	937	11	most	most	RBS
cord-006702-ekf6mja9	937	12	relevant	relevant	JJ
cord-006702-ekf6mja9	937	13	pathway	pathway	NN
cord-006702-ekf6mja9	937	14	in	in	IN
cord-006702-ekf6mja9	937	15	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	937	16	metabolism	metabolism	NN
cord-006702-ekf6mja9	937	17	,	,	,
cord-006702-ekf6mja9	937	18	of	of	IN
cord-006702-ekf6mja9	937	19	which	which	WDT
cord-006702-ekf6mja9	937	20	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	937	21	expression	expression	NN
cord-006702-ekf6mja9	937	22	showed	show	VBD
cord-006702-ekf6mja9	937	23	the	the	DT
cord-006702-ekf6mja9	937	24	greatest	great	JJS
cord-006702-ekf6mja9	937	25	downregulation	downregulation	NN
cord-006702-ekf6mja9	937	26	in	in	IN
cord-006702-ekf6mja9	937	27	IL13-transfected	il13-transfected	JJ
cord-006702-ekf6mja9	937	28	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	937	29	rats	rat	NNS
cord-006702-ekf6mja9	937	30	(	(	-LRB-
cord-006702-ekf6mja9	937	31	late	late	JJ
cord-006702-ekf6mja9	937	32	event	event	NN
cord-006702-ekf6mja9	937	33	)	)	-RRB-
cord-006702-ekf6mja9	937	34	,	,	,
cord-006702-ekf6mja9	937	35	and	and	CC
cord-006702-ekf6mja9	937	36	was	be	VBD
cord-006702-ekf6mja9	937	37	associated	associate	VBN
cord-006702-ekf6mja9	937	38	with	with	IN
cord-006702-ekf6mja9	937	39	HMGCR	HMGCR	NNP
cord-006702-ekf6mja9	937	40	upregulation	upregulation	NN
cord-006702-ekf6mja9	937	41	.	.	.
cord-006702-ekf6mja9	938	1	Plasma	plasma	NN
cord-006702-ekf6mja9	938	2	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	938	3	was	be	VBD
cord-006702-ekf6mja9	938	4	significantly	significantly	RB
cord-006702-ekf6mja9	938	5	elevated	elevate	VBN
cord-006702-ekf6mja9	938	6	from	from	IN
cord-006702-ekf6mja9	938	7	Week	week	NN
cord-006702-ekf6mja9	938	8	1	1	CD
cord-006702-ekf6mja9	938	9	(	(	-LRB-
cord-006702-ekf6mja9	938	10	HC	HC	NNP
cord-006702-ekf6mja9	938	11	rats	rat	NNS
cord-006702-ekf6mja9	938	12	)	)	-RRB-
cord-006702-ekf6mja9	938	13	and	and	CC
cord-006702-ekf6mja9	938	14	preceded	precede	VBD
cord-006702-ekf6mja9	938	15	the	the	DT
cord-006702-ekf6mja9	938	16	onset	onset	NN
cord-006702-ekf6mja9	938	17	of	of	IN
cord-006702-ekf6mja9	938	18	significant	significant	JJ
cord-006702-ekf6mja9	938	19	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	938	20	at	at	IN
cord-006702-ekf6mja9	938	21	Week	week	NN
cord-006702-ekf6mja9	938	22	10	10	CD
cord-006702-ekf6mja9	938	23	.	.	.
cord-006702-ekf6mja9	939	1	Study	study	NN
cord-006702-ekf6mja9	939	2	of	of	IN
cord-006702-ekf6mja9	939	3	these	these	DT
cord-006702-ekf6mja9	939	4	HC	HC	NNP
cord-006702-ekf6mja9	939	5	rats	rat	NNS
cord-006702-ekf6mja9	939	6	(	(	-LRB-
cord-006702-ekf6mja9	939	7	early	early	JJ
cord-006702-ekf6mja9	939	8	event	event	NN
cord-006702-ekf6mja9	939	9	)	)	-RRB-
cord-006702-ekf6mja9	939	10	also	also	RB
cord-006702-ekf6mja9	939	11	showed	show	VBD
cord-006702-ekf6mja9	939	12	reduced	reduce	VBN
cord-006702-ekf6mja9	939	13	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	939	14	,	,	,
cord-006702-ekf6mja9	939	15	and	and	CC
cord-006702-ekf6mja9	939	16	was	be	VBD
cord-006702-ekf6mja9	939	17	accompanied	accompany	VBN
cord-006702-ekf6mja9	939	18	by	by	IN
cord-006702-ekf6mja9	939	19	downregulation	downregulation	NN
cord-006702-ekf6mja9	939	20	of	of	IN
cord-006702-ekf6mja9	939	21	ABCA1	abca1	NN
cord-006702-ekf6mja9	939	22	and	and	CC
cord-006702-ekf6mja9	939	23	LXRa	LXRa	NNS
cord-006702-ekf6mja9	939	24	.	.	.
cord-006702-ekf6mja9	940	1	Similarly	similarly	RB
cord-006702-ekf6mja9	940	2	,	,	,
cord-006702-ekf6mja9	940	3	IL13-stimulated	il13-stimulated	CD
cord-006702-ekf6mja9	940	4	hepatocytes	hepatocyte	NNS
cord-006702-ekf6mja9	940	5	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	940	6	downregulation	downregulation	NN
cord-006702-ekf6mja9	940	7	of	of	IN
cord-006702-ekf6mja9	940	8	LXRa	LXRa	NNS
cord-006702-ekf6mja9	940	9	,	,	,
cord-006702-ekf6mja9	940	10	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	940	11	and	and	CC
cord-006702-ekf6mja9	940	12	ABCA1	abca1	XX
cord-006702-ekf6mja9	940	13	,	,	,
cord-006702-ekf6mja9	940	14	with	with	IN
cord-006702-ekf6mja9	940	15	reduced	reduce	VBN
cord-006702-ekf6mja9	940	16	ABCG5-and	ABCG5-and	NNP
cord-006702-ekf6mja9	940	17	ABCA1-mediated	ABCA1-mediated	NNP
cord-006702-ekf6mja9	940	18	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	940	19	effluxes	effluxes	NNP
cord-006702-ekf6mja9	940	20	.	.	.
cord-006702-ekf6mja9	941	1	Moreover	moreover	RB
cord-006702-ekf6mja9	941	2	LXRE	LXRE	NNP
cord-006702-ekf6mja9	941	3	-	-	HYPH
cord-006702-ekf6mja9	941	4	luciferase	luciferase	NN
cord-006702-ekf6mja9	941	5	transfected	transfecte	VBN
cord-006702-ekf6mja9	941	6	IL13-stimulated	IL13-stimulated	NNP
cord-006702-ekf6mja9	941	7	hepatocytes	hepatocyte	NNS
cord-006702-ekf6mja9	941	8	showed	show	VBD
cord-006702-ekf6mja9	941	9	decrease	decrease	NN
cord-006702-ekf6mja9	941	10	in	in	IN
cord-006702-ekf6mja9	941	11	luciferase	luciferase	NN
cord-006702-ekf6mja9	941	12	signal	signal	NN
cord-006702-ekf6mja9	941	13	indicating	indicate	VBG
cord-006702-ekf6mja9	941	14	reduced	reduce	VBN
cord-006702-ekf6mja9	941	15	LXRa	LXRa	NNS
cord-006702-ekf6mja9	941	16	activity	activity	NN
cord-006702-ekf6mja9	941	17	.	.	.
cord-006702-ekf6mja9	942	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	942	2	:	:	:
cord-006702-ekf6mja9	943	1	Hypercholesterolemia	Hypercholesterolemia	NNP
cord-006702-ekf6mja9	943	2	observed	observe	VBD
cord-006702-ekf6mja9	943	3	early	early	RB
cord-006702-ekf6mja9	943	4	in	in	IN
cord-006702-ekf6mja9	943	5	HC	HC	NNP
cord-006702-ekf6mja9	943	6	rats	rat	NNS
cord-006702-ekf6mja9	943	7	could	could	MD
cord-006702-ekf6mja9	943	8	be	be	VB
cord-006702-ekf6mja9	943	9	due	due	JJ
cord-006702-ekf6mja9	943	10	to	to	IN
cord-006702-ekf6mja9	943	11	downregulation	downregulation	NN
cord-006702-ekf6mja9	943	12	of	of	IN
cord-006702-ekf6mja9	943	13	LXRa	LXRa	NNS
cord-006702-ekf6mja9	943	14	-	-	:
cord-006702-ekf6mja9	943	15	ABCG5	ABCG5	NNP
cord-006702-ekf6mja9	944	1	/ABCA1	/ABCA1	:
cord-006702-ekf6mja9	944	2	pathway	pathway	JJ
cord-006702-ekf6mja9	944	3	with	with	IN
cord-006702-ekf6mja9	944	4	reduced	reduced	JJ
cord-006702-ekf6mja9	944	5	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	944	6	efflux	efflux	NN
cord-006702-ekf6mja9	944	7	into	into	IN
cord-006702-ekf6mja9	944	8	bile	bile	NN
cord-006702-ekf6mja9	944	9	,	,	,
cord-006702-ekf6mja9	944	10	resulting	result	VBG
cord-006702-ekf6mja9	944	11	in	in	IN
cord-006702-ekf6mja9	944	12	increased	increase	VBN
cord-006702-ekf6mja9	944	13	intracellular	intracellular	JJ
cord-006702-ekf6mja9	944	14	free	free	JJ
cord-006702-ekf6mja9	944	15	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	944	16	,	,	,
cord-006702-ekf6mja9	944	17	further	further	RB
cord-006702-ekf6mja9	944	18	inhibiting	inhibit	VBG
cord-006702-ekf6mja9	944	19	hepatic	hepatic	JJ
cord-006702-ekf6mja9	944	20	uptake	uptake	NN
cord-006702-ekf6mja9	944	21	of	of	IN
cord-006702-ekf6mja9	944	22	cholesterol	cholesterol	NN
cord-006702-ekf6mja9	944	23	.	.	.
cord-006702-ekf6mja9	945	1	Hepatic	hepatic	JJ
cord-006702-ekf6mja9	945	2	upregulation	upregulation	NN
cord-006702-ekf6mja9	945	3	of	of	IN
cord-006702-ekf6mja9	945	4	HMGCR	HMGCR	NNP
cord-006702-ekf6mja9	945	5	occurred	occur	VBD
cord-006702-ekf6mja9	945	6	secondarily	secondarily	RB
cord-006702-ekf6mja9	945	7	as	as	IN
cord-006702-ekf6mja9	945	8	a	a	DT
cord-006702-ekf6mja9	945	9	late	late	JJ
cord-006702-ekf6mja9	945	10	event	event	NN
cord-006702-ekf6mja9	945	11	following	follow	VBG
cord-006702-ekf6mja9	945	12	development	development	NN
cord-006702-ekf6mja9	945	13	of	of	IN
cord-006702-ekf6mja9	945	14	gross	gross	JJ
cord-006702-ekf6mja9	945	15	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	945	16	exacerbating	exacerbate	VBG
cord-006702-ekf6mja9	945	17	the	the	DT
cord-006702-ekf6mja9	945	18	hypercholesterolemia	hypercholesterolemia	NN
cord-006702-ekf6mja9	945	19	.	.	.
cord-006702-ekf6mja9	946	1	Autophagy	Autophagy	NNP
cord-006702-ekf6mja9	946	2	is	be	VBZ
cord-006702-ekf6mja9	946	3	activated	activate	VBN
cord-006702-ekf6mja9	946	4	to	to	TO
cord-006702-ekf6mja9	946	5	protect	protect	VB
cord-006702-ekf6mja9	946	6	podocyte	podocyte	NNP
cord-006702-ekf6mja9	946	7	from	from	IN
cord-006702-ekf6mja9	946	8	immune	immune	NN
cord-006702-ekf6mja9	946	9	-	-	HYPH
cord-006702-ekf6mja9	946	10	mediated	mediate	VBN
cord-006702-ekf6mja9	946	11	injury	injury	NN
cord-006702-ekf6mja9	946	12	in	in	IN
cord-006702-ekf6mja9	946	13	membranous	membranous	JJ
cord-006702-ekf6mja9	946	14	nephropathy	nephropathy	NN
cord-006702-ekf6mja9	946	15	Y.	Y.	NNP
cord-006702-ekf6mja9	946	16	Zhang	Zhang	NNP
cord-006702-ekf6mja9	946	17	,	,	,
cord-006702-ekf6mja9	946	18	F.	F.	NNP
cord-006702-ekf6mja9	946	19	Yang	Yang	NNP
cord-006702-ekf6mja9	946	20	,	,	,
cord-006702-ekf6mja9	946	21	Q.	Q.	NNP
cord-006702-ekf6mja9	946	22	LV	LV	NNP
cord-006702-ekf6mja9	946	23	,	,	,
cord-006702-ekf6mja9	946	24	.Z.	.Z.	.
cord-006702-ekf6mja9	947	1	Huang	Huang	NNP
cord-006702-ekf6mja9	947	2	,	,	,
cord-006702-ekf6mja9	947	3	H.	H.	NNP
cord-006702-ekf6mja9	947	4	Yuan	Yuan	NNP
cord-006702-ekf6mja9	947	5	,	,	,
cord-006702-ekf6mja9	947	6	J.	J.	NNP
cord-006702-ekf6mja9	947	7	Zhou	Zhou	NNP
cord-006702-ekf6mja9	947	8	Department	Department	NNP
cord-006702-ekf6mja9	947	9	of	of	IN
cord-006702-ekf6mja9	947	10	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	947	11	,	,	,
cord-006702-ekf6mja9	947	12	Tongji	Tongji	NNP
cord-006702-ekf6mja9	947	13	Hospital	Hospital	NNP
cord-006702-ekf6mja9	947	14	,	,	,
cord-006702-ekf6mja9	947	15	Tongji	Tongji	NNP
cord-006702-ekf6mja9	947	16	Medical	Medical	NNP
cord-006702-ekf6mja9	947	17	College	College	NNP
cord-006702-ekf6mja9	947	18	,	,	,
cord-006702-ekf6mja9	947	19	Huazhong	Huazhong	NNP
cord-006702-ekf6mja9	947	20	University	University	NNP
cord-006702-ekf6mja9	947	21	of	of	IN
cord-006702-ekf6mja9	947	22	Science	Science	NNP
cord-006702-ekf6mja9	947	23	and	and	CC
cord-006702-ekf6mja9	947	24	Technology	Technology	NNP
cord-006702-ekf6mja9	947	25	,	,	,
cord-006702-ekf6mja9	947	26	Wuhan	Wuhan	NNP
cord-006702-ekf6mja9	947	27	,	,	,
cord-006702-ekf6mja9	948	1	China	China	NNP
cord-006702-ekf6mja9	948	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	948	3	:	:	:
cord-006702-ekf6mja9	949	1	Autophagy	Autophagy	NNP
cord-006702-ekf6mja9	949	2	is	be	VBZ
cord-006702-ekf6mja9	949	3	induced	induce	VBN
cord-006702-ekf6mja9	949	4	in	in	IN
cord-006702-ekf6mja9	949	5	podocytes	podocyte	NNS
cord-006702-ekf6mja9	949	6	during	during	IN
cord-006702-ekf6mja9	949	7	various	various	JJ
cord-006702-ekf6mja9	949	8	kidney	kidney	NN
cord-006702-ekf6mja9	949	9	diseases	disease	NNS
cord-006702-ekf6mja9	949	10	,	,	,
cord-006702-ekf6mja9	949	11	however	however	RB
cord-006702-ekf6mja9	949	12	,	,	,
cord-006702-ekf6mja9	949	13	whether	whether	IN
cord-006702-ekf6mja9	949	14	this	this	DT
cord-006702-ekf6mja9	949	15	is	be	VBZ
cord-006702-ekf6mja9	949	16	protective	protective	JJ
cord-006702-ekf6mja9	949	17	or	or	CC
cord-006702-ekf6mja9	949	18	injurious	injurious	JJ
cord-006702-ekf6mja9	949	19	remains	remain	VBZ
cord-006702-ekf6mja9	949	20	controversial	controversial	JJ
cord-006702-ekf6mja9	949	21	.	.	.
cord-006702-ekf6mja9	950	1	Here	here	RB
cord-006702-ekf6mja9	950	2	,	,	,
cord-006702-ekf6mja9	950	3	we	-PRON-	PRP
cord-006702-ekf6mja9	950	4	address	address	VBP
cord-006702-ekf6mja9	950	5	this	this	DT
cord-006702-ekf6mja9	950	6	question	question	NN
cord-006702-ekf6mja9	950	7	by	by	IN
cord-006702-ekf6mja9	950	8	pharmacologic	pharmacologic	JJ
cord-006702-ekf6mja9	950	9	blockade	blockade	NN
cord-006702-ekf6mja9	950	10	/	/	SYM
cord-006702-ekf6mja9	950	11	activation	activation	NN
cord-006702-ekf6mja9	950	12	of	of	IN
cord-006702-ekf6mja9	950	13	autophagy	autophagy	NN
cord-006702-ekf6mja9	950	14	using	use	VBG
cord-006702-ekf6mja9	950	15	in	in	IN
cord-006702-ekf6mja9	950	16	vivo	vivo	NN
cord-006702-ekf6mja9	950	17	and	and	CC
cord-006702-ekf6mja9	950	18	in	in	IN
cord-006702-ekf6mja9	950	19	vitro	vitro	FW
cord-006702-ekf6mja9	950	20	model	model	NN
cord-006702-ekf6mja9	950	21	of	of	IN
cord-006702-ekf6mja9	950	22	membranous	membranous	JJ
cord-006702-ekf6mja9	950	23	nephropathy	nephropathy	NN
cord-006702-ekf6mja9	950	24	.	.	.
cord-006702-ekf6mja9	951	1	Methods	method	NNS
cord-006702-ekf6mja9	951	2	:	:	:
cord-006702-ekf6mja9	951	3	We	-PRON-	PRP
cord-006702-ekf6mja9	951	4	studied	study	VBD
cord-006702-ekf6mja9	951	5	female	female	JJ
cord-006702-ekf6mja9	951	6	SD	sd	NN
cord-006702-ekf6mja9	951	7	rats	rat	NNS
cord-006702-ekf6mja9	951	8	at	at	IN
cord-006702-ekf6mja9	951	9	day	day	NN
cord-006702-ekf6mja9	951	10	21	21	CD
cord-006702-ekf6mja9	951	11	after	after	IN
cord-006702-ekf6mja9	951	12	induction	induction	NN
cord-006702-ekf6mja9	951	13	of	of	IN
cord-006702-ekf6mja9	951	14	passive	passive	JJ
cord-006702-ekf6mja9	951	15	Heymann	Heymann	NNP
cord-006702-ekf6mja9	951	16	nephritis	nephritis	NN
cord-006702-ekf6mja9	951	17	(	(	-LRB-
cord-006702-ekf6mja9	951	18	PHN	PHN	NNP
cord-006702-ekf6mja9	951	19	)	)	-RRB-
cord-006702-ekf6mja9	951	20	by	by	IN
cord-006702-ekf6mja9	951	21	injection	injection	NN
cord-006702-ekf6mja9	951	22	of	of	IN
cord-006702-ekf6mja9	951	23	anti	anti	JJ
cord-006702-ekf6mja9	951	24	-	-	JJ
cord-006702-ekf6mja9	951	25	Fx1A.	fx1a.	JJ
cord-006702-ekf6mja9	951	26	Expressions	expression	NNS
cord-006702-ekf6mja9	951	27	of	of	IN
cord-006702-ekf6mja9	951	28	autophagy	autophagy	NN
cord-006702-ekf6mja9	951	29	markers	marker	NNS
cord-006702-ekf6mja9	951	30	and	and	CC
cord-006702-ekf6mja9	951	31	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	951	32	-	-	HYPH
cord-006702-ekf6mja9	951	33	associated	associate	VBN
cord-006702-ekf6mja9	951	34	proteins	protein	NNS
cord-006702-ekf6mja9	951	35	were	be	VBD
cord-006702-ekf6mja9	951	36	analyzed	analyze	VBN
cord-006702-ekf6mja9	951	37	.	.	.
cord-006702-ekf6mja9	952	1	Confocal	Confocal	NNP
cord-006702-ekf6mja9	952	2	microscopy	microscopy	NNS
cord-006702-ekf6mja9	952	3	was	be	VBD
cord-006702-ekf6mja9	952	4	used	use	VBN
cord-006702-ekf6mja9	952	5	to	to	TO
cord-006702-ekf6mja9	952	6	explore	explore	VB
cord-006702-ekf6mja9	952	7	the	the	DT
cord-006702-ekf6mja9	952	8	expression	expression	NN
cord-006702-ekf6mja9	952	9	patterns	pattern	NNS
cord-006702-ekf6mja9	952	10	of	of	IN
cord-006702-ekf6mja9	952	11	F	F	NNP
cord-006702-ekf6mja9	952	12	-	-	HYPH
cord-006702-ekf6mja9	952	13	actin	actin	NNP
cord-006702-ekf6mja9	952	14	and	and	CC
cord-006702-ekf6mja9	952	15	nephrin	nephrin	NNP
cord-006702-ekf6mja9	952	16	.	.	.
cord-006702-ekf6mja9	953	1	Attachment	attachment	NN
cord-006702-ekf6mja9	953	2	assay	assay	NN
cord-006702-ekf6mja9	953	3	was	be	VBD
cord-006702-ekf6mja9	953	4	used	use	VBN
cord-006702-ekf6mja9	953	5	to	to	TO
cord-006702-ekf6mja9	953	6	assess	assess	VB
cord-006702-ekf6mja9	953	7	the	the	DT
cord-006702-ekf6mja9	953	8	adhesion	adhesion	NN
cord-006702-ekf6mja9	953	9	of	of	IN
cord-006702-ekf6mja9	953	10	podocyte	podocyte	NNP
cord-006702-ekf6mja9	953	11	.	.	.
cord-006702-ekf6mja9	954	1	Apoptosis	apoptosis	NN
cord-006702-ekf6mja9	954	2	and	and	CC
cord-006702-ekf6mja9	954	3	expression	expression	NN
cord-006702-ekf6mja9	954	4	of	of	IN
cord-006702-ekf6mja9	954	5	integrin	integrin	NN
cord-006702-ekf6mja9	954	6	-	-	:
cord-006702-ekf6mja9	954	7	α3	α3	NN
cord-006702-ekf6mja9	954	8	were	be	VBD
cord-006702-ekf6mja9	954	9	measured	measure	VBN
cord-006702-ekf6mja9	954	10	by	by	IN
cord-006702-ekf6mja9	954	11	flow	flow	NN
cord-006702-ekf6mja9	954	12	cytometry	cytometry	NN
cord-006702-ekf6mja9	954	13	.	.	.
cord-006702-ekf6mja9	955	1	Results	result	NNS
cord-006702-ekf6mja9	955	2	:	:	:
cord-006702-ekf6mja9	956	1	First	first	RB
cord-006702-ekf6mja9	956	2	,	,	,
cord-006702-ekf6mja9	956	3	autophagy	autophagy	NN
cord-006702-ekf6mja9	956	4	was	be	VBD
cord-006702-ekf6mja9	956	5	induced	induce	VBN
cord-006702-ekf6mja9	956	6	in	in	IN
cord-006702-ekf6mja9	956	7	vivo	vivo	NNP
cord-006702-ekf6mja9	956	8	in	in	IN
cord-006702-ekf6mja9	956	9	podocytes	podocyte	NNS
cord-006702-ekf6mja9	956	10	of	of	IN
cord-006702-ekf6mja9	956	11	PHN	PHN	NNP
cord-006702-ekf6mja9	956	12	rats	rat	NNS
cord-006702-ekf6mja9	956	13	(	(	-LRB-
cord-006702-ekf6mja9	956	14	shown	show	VBN
cord-006702-ekf6mja9	956	15	by	by	IN
cord-006702-ekf6mja9	956	16	increased	increase	VBN
cord-006702-ekf6mja9	956	17	autophagosome	autophagosome	JJ
cord-006702-ekf6mja9	956	18	number	number	NN
cord-006702-ekf6mja9	956	19	,	,	,
cord-006702-ekf6mja9	956	20	conversion	conversion	NN
cord-006702-ekf6mja9	956	21	of	of	IN
cord-006702-ekf6mja9	956	22	LC3-I	LC3-I	NNP
cord-006702-ekf6mja9	956	23	to	to	IN
cord-006702-ekf6mja9	956	24	LC3-II	lc3-ii	NN
cord-006702-ekf6mja9	956	25	,	,	,
cord-006702-ekf6mja9	956	26	and	and	CC
cord-006702-ekf6mja9	956	27	Beclin-1	Beclin-1	NNP
cord-006702-ekf6mja9	956	28	expression	expression	NN
cord-006702-ekf6mja9	956	29	)	)	-RRB-
cord-006702-ekf6mja9	956	30	.	.	.
cord-006702-ekf6mja9	957	1	3-Methyladenine	3-Methyladenine	NNP
cord-006702-ekf6mja9	957	2	(	(	-LRB-
cord-006702-ekf6mja9	957	3	3-MA	3-ma	CD
cord-006702-ekf6mja9	957	4	)	)	-RRB-
cord-006702-ekf6mja9	957	5	blocked	block	VBN
cord-006702-ekf6mja9	957	6	autophagic	autophagic	NN
cord-006702-ekf6mja9	957	7	flux	flux	NN
cord-006702-ekf6mja9	957	8	and	and	CC
cord-006702-ekf6mja9	957	9	worsened	worsen	VBD
cord-006702-ekf6mja9	957	10	renal	renal	JJ
cord-006702-ekf6mja9	957	11	injury	injury	NN
cord-006702-ekf6mja9	957	12	in	in	IN
cord-006702-ekf6mja9	957	13	PHN	PHN	NNP
cord-006702-ekf6mja9	957	14	rats	rat	NNS
cord-006702-ekf6mja9	957	15	.	.	.
cord-006702-ekf6mja9	958	1	Compared	compare	VBN
cord-006702-ekf6mja9	958	2	with	with	IN
cord-006702-ekf6mja9	958	3	control	control	NN
cord-006702-ekf6mja9	958	4	littermates	littermate	NNS
cord-006702-ekf6mja9	958	5	,	,	,
cord-006702-ekf6mja9	958	6	the	the	DT
cord-006702-ekf6mja9	958	7	3-MA	3-ma	CD
cord-006702-ekf6mja9	958	8	-	-	HYPH
cord-006702-ekf6mja9	958	9	treated	treat	VBN
cord-006702-ekf6mja9	958	10	rats	rat	NNS
cord-006702-ekf6mja9	958	11	were	be	VBD
cord-006702-ekf6mja9	958	12	markedly	markedly	RB
cord-006702-ekf6mja9	958	13	more	more	RBR
cord-006702-ekf6mja9	958	14	sensitive	sensitive	JJ
cord-006702-ekf6mja9	958	15	to	to	IN
cord-006702-ekf6mja9	958	16	nephritis	nephritis	NN
cord-006702-ekf6mja9	958	17	as	as	IN
cord-006702-ekf6mja9	958	18	indicated	indicate	VBN
cord-006702-ekf6mja9	958	19	by	by	IN
cord-006702-ekf6mja9	958	20	increased	increase	VBN
cord-006702-ekf6mja9	958	21	urinary	urinary	JJ
cord-006702-ekf6mja9	958	22	protein	protein	NN
cord-006702-ekf6mja9	958	23	excretion	excretion	NN
cord-006702-ekf6mja9	958	24	,	,	,
cord-006702-ekf6mja9	958	25	glomerular	glomerular	JJ
cord-006702-ekf6mja9	958	26	lesions	lesion	NNS
cord-006702-ekf6mja9	958	27	,	,	,
cord-006702-ekf6mja9	958	28	and	and	CC
cord-006702-ekf6mja9	958	29	podocyte	podocyte	RB
cord-006702-ekf6mja9	958	30	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	958	31	.	.	.
cord-006702-ekf6mja9	959	1	Subsequently	subsequently	RB
cord-006702-ekf6mja9	959	2	,	,	,
cord-006702-ekf6mja9	959	3	we	-PRON-	PRP
cord-006702-ekf6mja9	959	4	utilized	utilize	VBD
cord-006702-ekf6mja9	959	5	immortalized	immortalize	VBD
cord-006702-ekf6mja9	959	6	mouse	mouse	NN
cord-006702-ekf6mja9	959	7	podocytes	podocytes	NNP
cord-006702-ekf6mja9	959	8	(	(	-LRB-
cord-006702-ekf6mja9	959	9	MPC5	MPC5	NNP
cord-006702-ekf6mja9	959	10	)	)	-RRB-
cord-006702-ekf6mja9	959	11	to	to	TO
cord-006702-ekf6mja9	959	12	study	study	VB
cord-006702-ekf6mja9	959	13	the	the	DT
cord-006702-ekf6mja9	959	14	autophagy	autophagy	NN
cord-006702-ekf6mja9	959	15	mechanisms	mechanism	NNS
cord-006702-ekf6mja9	959	16	involved	involve	VBN
cord-006702-ekf6mja9	959	17	in	in	IN
cord-006702-ekf6mja9	959	18	MN	MN	NNP
cord-006702-ekf6mja9	959	19	with	with	IN
cord-006702-ekf6mja9	959	20	sC5b-9	sC5b-9	NNP
cord-006702-ekf6mja9	959	21	incubation	incubation	NN
cord-006702-ekf6mja9	959	22	in	in	IN
cord-006702-ekf6mja9	959	23	vitro	vitro	FW
cord-006702-ekf6mja9	959	24	.	.	.
cord-006702-ekf6mja9	960	1	Podocyte	Podocyte	NNP
cord-006702-ekf6mja9	960	2	damage	damage	NN
cord-006702-ekf6mja9	961	1	,	,	,
cord-006702-ekf6mja9	961	2	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	961	3	and	and	CC
cord-006702-ekf6mja9	961	4	deadhesion	deadhesion	NN
cord-006702-ekf6mja9	961	5	were	be	VBD
cord-006702-ekf6mja9	961	6	demonstrated	demonstrate	VBN
cord-006702-ekf6mja9	961	7	in	in	IN
cord-006702-ekf6mja9	961	8	the	the	DT
cord-006702-ekf6mja9	961	9	sC5b-9-incubated	sC5b-9-incubated	NNP
cord-006702-ekf6mja9	961	10	MPC5	MPC5	NNP
cord-006702-ekf6mja9	961	11	cells	cell	NNS
cord-006702-ekf6mja9	961	12	.	.	.
cord-006702-ekf6mja9	962	1	Furthermore	furthermore	RB
cord-006702-ekf6mja9	962	2	,	,	,
cord-006702-ekf6mja9	962	3	sC5b-9	sc5b-9	NN
cord-006702-ekf6mja9	962	4	induced	induce	VBN
cord-006702-ekf6mja9	962	5	Beclin-1	Beclin-1	NNP
cord-006702-ekf6mja9	962	6	and	and	CC
cord-006702-ekf6mja9	962	7	LC3-II	lc3-ii	NN
cord-006702-ekf6mja9	962	8	expressions	expression	NNS
cord-006702-ekf6mja9	962	9	and	and	CC
cord-006702-ekf6mja9	962	10	autophagosome	autophagosome	JJ
cord-006702-ekf6mja9	962	11	formation	formation	NN
cord-006702-ekf6mja9	962	12	.	.	.
cord-006702-ekf6mja9	963	1	Inhibiting	inhibit	VBG
cord-006702-ekf6mja9	963	2	autophagy	autophagy	NN
cord-006702-ekf6mja9	963	3	by	by	IN
cord-006702-ekf6mja9	963	4	3-MA	3-ma	CD
cord-006702-ekf6mja9	963	5	further	further	RB
cord-006702-ekf6mja9	963	6	promoted	promote	VBN
cord-006702-ekf6mja9	963	7	cellular	cellular	JJ
cord-006702-ekf6mja9	963	8	lesions	lesion	NNS
cord-006702-ekf6mja9	963	9	,	,	,
cord-006702-ekf6mja9	963	10	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	963	11	and	and	CC
cord-006702-ekf6mja9	963	12	actin	actin	NN
cord-006702-ekf6mja9	963	13	reorganization	reorganization	NN
cord-006702-ekf6mja9	963	14	-	-	HYPH
cord-006702-ekf6mja9	963	15	associated	associate	VBN
cord-006702-ekf6mja9	963	16	deadhesion	deadhesion	NN
cord-006702-ekf6mja9	963	17	in	in	IN
cord-006702-ekf6mja9	963	18	the	the	DT
cord-006702-ekf6mja9	963	19	sC5b-9-incubated	sC5b-9-incubated	NNP
cord-006702-ekf6mja9	963	20	MPC5	MPC5	NNP
cord-006702-ekf6mja9	963	21	cells	cell	NNS
cord-006702-ekf6mja9	963	22	.	.	.
cord-006702-ekf6mja9	964	1	In	in	IN
cord-006702-ekf6mja9	964	2	contrast	contrast	NN
cord-006702-ekf6mja9	964	3	,	,	,
cord-006702-ekf6mja9	964	4	rapamycin	rapamycin	NN
cord-006702-ekf6mja9	964	5	,	,	,
cord-006702-ekf6mja9	964	6	an	an	DT
cord-006702-ekf6mja9	964	7	autophagy	autophagy	NN
cord-006702-ekf6mja9	964	8	inducer	inducer	NN
cord-006702-ekf6mja9	964	9	,	,	,
cord-006702-ekf6mja9	964	10	promoted	promote	VBD
cord-006702-ekf6mja9	964	11	Beclin-1	Beclin-1	NNP
cord-006702-ekf6mja9	964	12	and	and	CC
cord-006702-ekf6mja9	964	13	LC3-II	lc3-ii	NN
cord-006702-ekf6mja9	964	14	expressions	expression	NNS
cord-006702-ekf6mja9	964	15	,	,	,
cord-006702-ekf6mja9	964	16	which	which	WDT
cord-006702-ekf6mja9	964	17	mitigated	mitigate	VBD
cord-006702-ekf6mja9	964	18	sC5b-9-induced	sc5b-9-induced	JJ
cord-006702-ekf6mja9	964	19	changes	change	NNS
cord-006702-ekf6mja9	964	20	in	in	IN
cord-006702-ekf6mja9	964	21	the	the	DT
cord-006702-ekf6mja9	964	22	injury	injury	NN
cord-006702-ekf6mja9	964	23	-	-	HYPH
cord-006702-ekf6mja9	964	24	related	relate	VBN
cord-006702-ekf6mja9	964	25	morphology	morphology	NN
cord-006702-ekf6mja9	964	26	,	,	,
cord-006702-ekf6mja9	964	27	apoptosis	apoptosis	NN
cord-006702-ekf6mja9	964	28	,	,	,
cord-006702-ekf6mja9	964	29	and	and	CC
cord-006702-ekf6mja9	964	30	deadhesion	deadhesion	NN
cord-006702-ekf6mja9	964	31	of	of	IN
cord-006702-ekf6mja9	964	32	MPC5	MPC5	NNP
cord-006702-ekf6mja9	964	33	cells	cell	NNS
cord-006702-ekf6mja9	964	34	.	.	.
cord-006702-ekf6mja9	965	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	965	2	:	:	:
cord-006702-ekf6mja9	966	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	966	2	results	result	NNS
cord-006702-ekf6mja9	966	3	establish	establish	VBP
cord-006702-ekf6mja9	966	4	a	a	DT
cord-006702-ekf6mja9	966	5	renoprotective	renoprotective	JJ
cord-006702-ekf6mja9	966	6	role	role	NN
cord-006702-ekf6mja9	966	7	of	of	IN
cord-006702-ekf6mja9	966	8	podocyte	podocyte	JJ
cord-006702-ekf6mja9	966	9	autophagy	autophagy	NN
cord-006702-ekf6mja9	966	10	in	in	IN
cord-006702-ekf6mja9	966	11	complement	complement	NN
cord-006702-ekf6mja9	966	12	-	-	HYPH
cord-006702-ekf6mja9	966	13	mediated	mediate	VBN
cord-006702-ekf6mja9	966	14	podocytopathy	podocytopathy	NN
cord-006702-ekf6mja9	966	15	where	where	WRB
cord-006702-ekf6mja9	966	16	it	-PRON-	PRP
cord-006702-ekf6mja9	966	17	may	may	MD
cord-006702-ekf6mja9	966	18	interfere	interfere	VB
cord-006702-ekf6mja9	966	19	with	with	IN
cord-006702-ekf6mja9	966	20	cell	cell	NN
cord-006702-ekf6mja9	966	21	killing	killing	NN
cord-006702-ekf6mja9	966	22	and	and	CC
cord-006702-ekf6mja9	966	23	adhesion	adhesion	NN
cord-006702-ekf6mja9	966	24	mechanisms	mechanism	NNS
cord-006702-ekf6mja9	966	25	.	.	.
cord-006702-ekf6mja9	967	1	Results	result	NNS
cord-006702-ekf6mja9	967	2	:	:	:
cord-006702-ekf6mja9	968	1	Data	datum	NNS
cord-006702-ekf6mja9	968	2	on	on	IN
cord-006702-ekf6mja9	968	3	61	61	CD
cord-006702-ekf6mja9	968	4	children	child	NNS
cord-006702-ekf6mja9	968	5	(	(	-LRB-
cord-006702-ekf6mja9	968	6	32	32	CD
cord-006702-ekf6mja9	968	7	male	male	NN
cord-006702-ekf6mja9	968	8	)	)	-RRB-
cord-006702-ekf6mja9	968	9	from	from	IN
cord-006702-ekf6mja9	968	10	12	12	CD
cord-006702-ekf6mja9	968	11	centres	centre	NNS
cord-006702-ekf6mja9	968	12	were	be	VBD
cord-006702-ekf6mja9	968	13	analysed	analyse	VBN
cord-006702-ekf6mja9	968	14	.	.	.
cord-006702-ekf6mja9	969	1	Shortterm	shortterm	JJ
cord-006702-ekf6mja9	969	2	dialysis	dialysis	NN
cord-006702-ekf6mja9	969	3	(	(	-LRB-
cord-006702-ekf6mja9	969	4	<	<	NNP
cord-006702-ekf6mja9	969	5	4	4	CD
cord-006702-ekf6mja9	969	6	weeks	week	NNS
cord-006702-ekf6mja9	969	7	)	)	-RRB-
cord-006702-ekf6mja9	969	8	was	be	VBD
cord-006702-ekf6mja9	969	9	required	require	VBN
cord-006702-ekf6mja9	969	10	in	in	IN
cord-006702-ekf6mja9	969	11	5	5	CD
cord-006702-ekf6mja9	969	12	(	(	-LRB-
cord-006702-ekf6mja9	969	13	8	8	CD
cord-006702-ekf6mja9	969	14	%	%	NN
cord-006702-ekf6mja9	969	15	)	)	-RRB-
cord-006702-ekf6mja9	969	16	children	child	NNS
cord-006702-ekf6mja9	969	17	(	(	-LRB-
cord-006702-ekf6mja9	969	18	PD	PD	NNP
cord-006702-ekf6mja9	969	19	in	in	IN
cord-006702-ekf6mja9	969	20	2	2	CD
cord-006702-ekf6mja9	969	21	,	,	,
cord-006702-ekf6mja9	969	22	CVVH	CVVH	NNP
cord-006702-ekf6mja9	969	23	in	in	IN
cord-006702-ekf6mja9	969	24	2	2	CD
cord-006702-ekf6mja9	969	25	and	and	CC
cord-006702-ekf6mja9	969	26	HD	hd	NN
cord-006702-ekf6mja9	969	27	in	in	IN
cord-006702-ekf6mja9	969	28	1	1	CD
cord-006702-ekf6mja9	969	29	)	)	-RRB-
cord-006702-ekf6mja9	969	30	at	at	IN
cord-006702-ekf6mja9	969	31	a	a	DT
cord-006702-ekf6mja9	969	32	median	median	JJ
cord-006702-ekf6mja9	969	33	age	age	NN
cord-006702-ekf6mja9	969	34	of	of	IN
cord-006702-ekf6mja9	969	35	11	11	CD
cord-006702-ekf6mja9	969	36	(	(	-LRB-
cord-006702-ekf6mja9	969	37	5	5	CD
cord-006702-ekf6mja9	969	38	-	-	SYM
cord-006702-ekf6mja9	969	39	16	16	CD
cord-006702-ekf6mja9	969	40	)	)	-RRB-
cord-006702-ekf6mja9	969	41	weeks	week	NNS
cord-006702-ekf6mja9	969	42	for	for	IN
cord-006702-ekf6mja9	969	43	a	a	DT
cord-006702-ekf6mja9	969	44	median	median	JJ
cord-006702-ekf6mja9	969	45	duration	duration	NN
cord-006702-ekf6mja9	969	46	of	of	IN
cord-006702-ekf6mja9	969	47	16	16	CD
cord-006702-ekf6mja9	969	48	(	(	-LRB-
cord-006702-ekf6mja9	969	49	8	8	CD
cord-006702-ekf6mja9	969	50	-	-	SYM
cord-006702-ekf6mja9	969	51	18	18	CD
cord-006702-ekf6mja9	969	52	)	)	-RRB-
cord-006702-ekf6mja9	969	53	days	day	NNS
cord-006702-ekf6mja9	969	54	secondary	secondary	JJ
cord-006702-ekf6mja9	969	55	to	to	IN
cord-006702-ekf6mja9	969	56	sepsis	sepsis	NN
cord-006702-ekf6mja9	969	57	(	(	-LRB-
cord-006702-ekf6mja9	969	58	n=2	n=2	NNS
cord-006702-ekf6mja9	969	59	)	)	-RRB-
cord-006702-ekf6mja9	969	60	,	,	,
cord-006702-ekf6mja9	969	61	acute	acute	JJ
cord-006702-ekf6mja9	969	62	fluid	fluid	JJ
cord-006702-ekf6mja9	969	63	overload	overload	NN
cord-006702-ekf6mja9	969	64	(	(	-LRB-
cord-006702-ekf6mja9	969	65	n=2	n=2	NNS
cord-006702-ekf6mja9	969	66	)	)	-RRB-
cord-006702-ekf6mja9	969	67	or	or	CC
cord-006702-ekf6mja9	969	68	AKI	AKI	NNP
cord-006702-ekf6mja9	969	69	following	follow	VBG
cord-006702-ekf6mja9	969	70	ACEI	ACEI	NNP
cord-006702-ekf6mja9	969	71	(	(	-LRB-
cord-006702-ekf6mja9	969	72	n=1	n=1	NN
cord-006702-ekf6mja9	969	73	)	)	-RRB-
cord-006702-ekf6mja9	969	74	.	.	.
cord-006702-ekf6mja9	970	1	Thirteen	thirteen	CD
cord-006702-ekf6mja9	970	2	(	(	-LRB-
cord-006702-ekf6mja9	970	3	21	21	CD
cord-006702-ekf6mja9	970	4	%	%	NN
cord-006702-ekf6mja9	970	5	)	)	-RRB-
cord-006702-ekf6mja9	971	1	patients	patient	NNS
cord-006702-ekf6mja9	971	2	required	require	VBD
cord-006702-ekf6mja9	971	3	long	long	JJ
cord-006702-ekf6mja9	971	4	-	-	HYPH
cord-006702-ekf6mja9	971	5	term	term	NN
cord-006702-ekf6mja9	971	6	dialysis	dialysis	NN
cord-006702-ekf6mja9	971	7	by	by	IN
cord-006702-ekf6mja9	971	8	the	the	DT
cord-006702-ekf6mja9	971	9	age	age	NN
cord-006702-ekf6mja9	971	10	of	of	IN
cord-006702-ekf6mja9	971	11	6	6	CD
cord-006702-ekf6mja9	971	12	months	month	NNS
cord-006702-ekf6mja9	971	13	,	,	,
cord-006702-ekf6mja9	971	14	30	30	CD
cord-006702-ekf6mja9	971	15	(	(	-LRB-
cord-006702-ekf6mja9	971	16	50	50	CD
cord-006702-ekf6mja9	971	17	%	%	NN
cord-006702-ekf6mja9	971	18	)	)	-RRB-
cord-006702-ekf6mja9	971	19	by	by	IN
cord-006702-ekf6mja9	971	20	1	1	CD
cord-006702-ekf6mja9	971	21	year	year	NN
cord-006702-ekf6mja9	971	22	,	,	,
cord-006702-ekf6mja9	971	23	38	38	CD
cord-006702-ekf6mja9	971	24	(	(	-LRB-
cord-006702-ekf6mja9	971	25	62	62	CD
cord-006702-ekf6mja9	971	26	%	%	NN
cord-006702-ekf6mja9	971	27	)	)	-RRB-
cord-006702-ekf6mja9	971	28	by	by	IN
cord-006702-ekf6mja9	971	29	2	2	CD
cord-006702-ekf6mja9	971	30	years	year	NNS
cord-006702-ekf6mja9	971	31	,	,	,
cord-006702-ekf6mja9	971	32	41	41	CD
cord-006702-ekf6mja9	971	33	(	(	-LRB-
cord-006702-ekf6mja9	971	34	67	67	CD
cord-006702-ekf6mja9	971	35	%	%	NN
cord-006702-ekf6mja9	971	36	)	)	-RRB-
cord-006702-ekf6mja9	971	37	by	by	IN
cord-006702-ekf6mja9	971	38	final	final	JJ
cord-006702-ekf6mja9	971	39	follow	follow	VB
cord-006702-ekf6mja9	971	40	up	up	RP
cord-006702-ekf6mja9	971	41	at	at	IN
cord-006702-ekf6mja9	971	42	a	a	DT
cord-006702-ekf6mja9	971	43	median	median	NN
cord-006702-ekf6mja9	971	44	of	of	IN
cord-006702-ekf6mja9	971	45	34	34	CD
cord-006702-ekf6mja9	971	46	months	month	NNS
cord-006702-ekf6mja9	971	47	.	.	.
cord-006702-ekf6mja9	972	1	Of	of	IN
cord-006702-ekf6mja9	972	2	those	those	DT
cord-006702-ekf6mja9	972	3	,	,	,
cord-006702-ekf6mja9	972	4	9	9	CD
cord-006702-ekf6mja9	972	5	(	(	-LRB-
cord-006702-ekf6mja9	972	6	22	22	CD
cord-006702-ekf6mja9	972	7	%	%	NN
cord-006702-ekf6mja9	972	8	)	)	-RRB-
cord-006702-ekf6mja9	972	9	patients	patient	NNS
cord-006702-ekf6mja9	972	10	did	do	VBD
cord-006702-ekf6mja9	972	11	not	not	RB
cord-006702-ekf6mja9	972	12	have	have	VB
cord-006702-ekf6mja9	972	13	nephrectomies	nephrectomy	NNS
cord-006702-ekf6mja9	972	14	,	,	,
cord-006702-ekf6mja9	972	15	29	29	CD
cord-006702-ekf6mja9	972	16	(	(	-LRB-
cord-006702-ekf6mja9	972	17	71	71	CD
cord-006702-ekf6mja9	972	18	%	%	NN
cord-006702-ekf6mja9	972	19	)	)	-RRB-
cord-006702-ekf6mja9	972	20	had	have	VBD
cord-006702-ekf6mja9	972	21	nephrectomies	nephrectomy	NNS
cord-006702-ekf6mja9	972	22	before	before	RB
cord-006702-ekf6mja9	972	23	and	and	CC
cord-006702-ekf6mja9	972	24	3	3	CD
cord-006702-ekf6mja9	972	25	(	(	-LRB-
cord-006702-ekf6mja9	972	26	7	7	CD
cord-006702-ekf6mja9	972	27	%	%	NN
cord-006702-ekf6mja9	972	28	)	)	-RRB-
cord-006702-ekf6mja9	972	29	after	after	IN
cord-006702-ekf6mja9	972	30	commencingdialysis	commencingdialysis	NN
cord-006702-ekf6mja9	972	31	.	.	.
cord-006702-ekf6mja9	973	1	In	in	IN
cord-006702-ekf6mja9	973	2	37	37	CD
cord-006702-ekf6mja9	973	3	(	(	-LRB-
cord-006702-ekf6mja9	973	4	90	90	CD
cord-006702-ekf6mja9	973	5	%	%	NN
cord-006702-ekf6mja9	973	6	)	)	-RRB-
cord-006702-ekf6mja9	973	7	PD	PD	NNP
cord-006702-ekf6mja9	973	8	was	be	VBD
cord-006702-ekf6mja9	973	9	the	the	DT
cord-006702-ekf6mja9	973	10	modality	modality	NN
cord-006702-ekf6mja9	973	11	of	of	IN
cord-006702-ekf6mja9	973	12	choice	choice	NN
cord-006702-ekf6mja9	973	13	.	.	.
cord-006702-ekf6mja9	974	1	Amongst	amongst	IN
cord-006702-ekf6mja9	974	2	those	those	DT
cord-006702-ekf6mja9	974	3	on	on	IN
cord-006702-ekf6mja9	974	4	PD	PD	NNP
cord-006702-ekf6mja9	974	5	,	,	,
cord-006702-ekf6mja9	974	6	CCPD	CCPD	NNP
cord-006702-ekf6mja9	974	7	with	with	IN
cord-006702-ekf6mja9	974	8	a	a	DT
cord-006702-ekf6mja9	974	9	day	day	NN
cord-006702-ekf6mja9	974	10	exchange	exchange	NN
cord-006702-ekf6mja9	974	11	was	be	VBD
cord-006702-ekf6mja9	974	12	the	the	DT
cord-006702-ekf6mja9	974	13	commonest	common	JJS
cord-006702-ekf6mja9	974	14	prescription	prescription	NN
cord-006702-ekf6mja9	974	15	(	(	-LRB-
cord-006702-ekf6mja9	974	16	43	43	CD
cord-006702-ekf6mja9	974	17	%	%	NN
cord-006702-ekf6mja9	974	18	)	)	-RRB-
cord-006702-ekf6mja9	974	19	.	.	.
cord-006702-ekf6mja9	975	1	Eleven	eleven	CD
cord-006702-ekf6mja9	975	2	(	(	-LRB-
cord-006702-ekf6mja9	975	3	30	30	CD
cord-006702-ekf6mja9	975	4	%	%	NN
cord-006702-ekf6mja9	975	5	)	)	-RRB-
cord-006702-ekf6mja9	975	6	patients	patient	NNS
cord-006702-ekf6mja9	975	7	needed	need	VBN
cord-006702-ekf6mja9	975	8	to	to	TO
cord-006702-ekf6mja9	975	9	switch	switch	VB
cord-006702-ekf6mja9	975	10	to	to	IN
cord-006702-ekf6mja9	975	11	HD	hd	NN
cord-006702-ekf6mja9	975	12	due	due	IN
cord-006702-ekf6mja9	975	13	to	to	IN
cord-006702-ekf6mja9	975	14	PD	PD	NNP
cord-006702-ekf6mja9	975	15	catheter	catheter	NN
cord-006702-ekf6mja9	975	16	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	975	17	(	(	-LRB-
cord-006702-ekf6mja9	975	18	n=5	n=5	NNP
cord-006702-ekf6mja9	975	19	)	)	-RRB-
cord-006702-ekf6mja9	975	20	,	,	,
cord-006702-ekf6mja9	975	21	peritonitis	peritonitis	NN
cord-006702-ekf6mja9	975	22	(	(	-LRB-
cord-006702-ekf6mja9	975	23	n=3	n=3	NN
cord-006702-ekf6mja9	975	24	)	)	-RRB-
cord-006702-ekf6mja9	975	25	,	,	,
cord-006702-ekf6mja9	975	26	inadequate	inadequate	JJ
cord-006702-ekf6mja9	975	27	UF	UF	NNP
cord-006702-ekf6mja9	975	28	(	(	-LRB-
cord-006702-ekf6mja9	975	29	n=2	n=2	NNS
cord-006702-ekf6mja9	975	30	)	)	-RRB-
cord-006702-ekf6mja9	975	31	or	or	CC
cord-006702-ekf6mja9	975	32	development	development	NN
cord-006702-ekf6mja9	975	33	of	of	IN
cord-006702-ekf6mja9	975	34	pleuro	pleuro	NN
cord-006702-ekf6mja9	975	35	-	-	HYPH
cord-006702-ekf6mja9	975	36	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	975	37	fistula	fistula	NN
cord-006702-ekf6mja9	975	38	(	(	-LRB-
cord-006702-ekf6mja9	975	39	n=1	n=1	FW
cord-006702-ekf6mja9	975	40	)	)	-RRB-
cord-006702-ekf6mja9	975	41	.	.	.
cord-006702-ekf6mja9	976	1	Peritonitis	peritonitis	NN
cord-006702-ekf6mja9	976	2	rate	rate	NN
cord-006702-ekf6mja9	976	3	was	be	VBD
cord-006702-ekf6mja9	976	4	0.95/12	0.95/12	CD
cord-006702-ekf6mja9	976	5	patient	patient	JJ
cord-006702-ekf6mja9	976	6	months	month	NNS
cord-006702-ekf6mja9	976	7	.	.	.
cord-006702-ekf6mja9	977	1	None	none	NN
cord-006702-ekf6mja9	977	2	developed	develop	VBD
cord-006702-ekf6mja9	977	3	thrombosis	thrombosis	NN
cord-006702-ekf6mja9	977	4	on	on	IN
cord-006702-ekf6mja9	977	5	PD	PD	NNP
cord-006702-ekf6mja9	977	6	.	.	.
cord-006702-ekf6mja9	978	1	All	all	DT
cord-006702-ekf6mja9	978	2	patients	patient	NNS
cord-006702-ekf6mja9	978	3	on	on	IN
cord-006702-ekf6mja9	978	4	HD	HD	NNP
cord-006702-ekf6mja9	978	5	received	receive	VBD
cord-006702-ekf6mja9	978	6	3	3	CD
cord-006702-ekf6mja9	978	7	sessions	session	NNS
cord-006702-ekf6mja9	978	8	of	of	IN
cord-006702-ekf6mja9	978	9	4	4	CD
cord-006702-ekf6mja9	978	10	hours	hour	NNS
cord-006702-ekf6mja9	978	11	per	per	IN
cord-006702-ekf6mja9	978	12	week	week	NN
cord-006702-ekf6mja9	978	13	.	.	.
cord-006702-ekf6mja9	979	1	No	no	DT
cord-006702-ekf6mja9	979	2	HD	hd	NN
cord-006702-ekf6mja9	979	3	line	line	NN
cord-006702-ekf6mja9	979	4	infections	infection	NNS
cord-006702-ekf6mja9	979	5	and	and	CC
cord-006702-ekf6mja9	979	6	no	no	DT
cord-006702-ekf6mja9	979	7	development	development	NN
cord-006702-ekf6mja9	979	8	of	of	IN
cord-006702-ekf6mja9	979	9	thrombosis	thrombosis	NN
cord-006702-ekf6mja9	979	10	were	be	VBD
cord-006702-ekf6mja9	979	11	reported	report	VBN
cord-006702-ekf6mja9	979	12	.	.	.
cord-006702-ekf6mja9	980	1	There	there	EX
cord-006702-ekf6mja9	980	2	was	be	VBD
cord-006702-ekf6mja9	980	3	no	no	DT
cord-006702-ekf6mja9	980	4	difference	difference	NN
cord-006702-ekf6mja9	980	5	in	in	IN
cord-006702-ekf6mja9	980	6	growth	growth	NN
cord-006702-ekf6mja9	980	7	between	between	IN
cord-006702-ekf6mja9	980	8	PD	PD	NNP
cord-006702-ekf6mja9	980	9	and	and	CC
cord-006702-ekf6mja9	980	10	HD	HD	NNP
cord-006702-ekf6mja9	980	11	patients	patient	NNS
cord-006702-ekf6mja9	980	12	.	.	.
cord-006702-ekf6mja9	981	1	Twenty	twenty	CD
cord-006702-ekf6mja9	981	2	-	-	HYPH
cord-006702-ekf6mja9	981	3	five	five	CD
cord-006702-ekf6mja9	981	4	patients	patient	NNS
cord-006702-ekf6mja9	981	5	(	(	-LRB-
cord-006702-ekf6mja9	981	6	61	61	CD
cord-006702-ekf6mja9	981	7	%	%	NN
cord-006702-ekf6mja9	981	8	)	)	-RRB-
cord-006702-ekf6mja9	981	9	received	receive	VBD
cord-006702-ekf6mja9	981	10	a	a	DT
cord-006702-ekf6mja9	981	11	transplant	transplant	NN
cord-006702-ekf6mja9	981	12	at	at	IN
cord-006702-ekf6mja9	981	13	a	a	DT
cord-006702-ekf6mja9	981	14	median	median	NN
cord-006702-ekf6mja9	981	15	of	of	IN
cord-006702-ekf6mja9	981	16	6.5	6.5	CD
cord-006702-ekf6mja9	981	17	(	(	-LRB-
cord-006702-ekf6mja9	981	18	0	0	CD
cord-006702-ekf6mja9	981	19	-	-	SYM
cord-006702-ekf6mja9	981	20	47	47	CD
cord-006702-ekf6mja9	981	21	)	)	-RRB-
cord-006702-ekf6mja9	981	22	months	month	NNS
cord-006702-ekf6mja9	981	23	after	after	IN
cord-006702-ekf6mja9	981	24	start	start	NN
cord-006702-ekf6mja9	981	25	of	of	IN
cord-006702-ekf6mja9	981	26	dialysis	dialysis	NN
cord-006702-ekf6mja9	981	27	of	of	IN
cord-006702-ekf6mja9	981	28	which	which	WDT
cord-006702-ekf6mja9	981	29	15	15	CD
cord-006702-ekf6mja9	981	30	with	with	IN
cord-006702-ekf6mja9	981	31	living	live	VBG
cord-006702-ekf6mja9	981	32	donor	donor	NN
cord-006702-ekf6mja9	981	33	.	.	.
cord-006702-ekf6mja9	982	1	One	one	CD
cord-006702-ekf6mja9	982	2	patient	patient	NN
cord-006702-ekf6mja9	982	3	died	die	VBD
cord-006702-ekf6mja9	982	4	whilst	whilst	IN
cord-006702-ekf6mja9	982	5	on	on	IN
cord-006702-ekf6mja9	982	6	PD	PD	NNP
cord-006702-ekf6mja9	982	7	(	(	-LRB-
cord-006702-ekf6mja9	982	8	palliative	palliative	JJ
cord-006702-ekf6mja9	982	9	treatment	treatment	NN
cord-006702-ekf6mja9	982	10	)	)	-RRB-
cord-006702-ekf6mja9	982	11	and	and	CC
cord-006702-ekf6mja9	982	12	2	2	CD
cord-006702-ekf6mja9	982	13	patients	patient	NNS
cord-006702-ekf6mja9	982	14	died	die	VBD
cord-006702-ekf6mja9	982	15	whilst	whilst	IN
cord-006702-ekf6mja9	982	16	on	on	IN
cord-006702-ekf6mja9	982	17	HD	hd	NN
cord-006702-ekf6mja9	982	18	(	(	-LRB-
cord-006702-ekf6mja9	982	19	hyperkalemia	hyperkalemia	NN
cord-006702-ekf6mja9	982	20	and	and	CC
cord-006702-ekf6mja9	982	21	candida	candida	NN
cord-006702-ekf6mja9	982	22	peritonitis	peritonitis	NN
cord-006702-ekf6mja9	982	23	)	)	-RRB-
cord-006702-ekf6mja9	982	24	.	.	.
cord-006702-ekf6mja9	983	1	The	the	DT
cord-006702-ekf6mja9	983	2	need	need	NN
cord-006702-ekf6mja9	983	3	for	for	IN
cord-006702-ekf6mja9	983	4	long	long	JJ
cord-006702-ekf6mja9	983	5	-	-	HYPH
cord-006702-ekf6mja9	983	6	term	term	NN
cord-006702-ekf6mja9	983	7	dialysis	dialysis	NN
cord-006702-ekf6mja9	983	8	in	in	IN
cord-006702-ekf6mja9	983	9	children	child	NNS
cord-006702-ekf6mja9	983	10	with	with	IN
cord-006702-ekf6mja9	983	11	CNS	CNS	NNP
cord-006702-ekf6mja9	983	12	is	be	VBZ
cord-006702-ekf6mja9	983	13	very	very	RB
cord-006702-ekf6mja9	983	14	likely	likely	JJ
cord-006702-ekf6mja9	983	15	by	by	IN
cord-006702-ekf6mja9	983	16	the	the	DT
cord-006702-ekf6mja9	983	17	age	age	NN
cord-006702-ekf6mja9	983	18	of	of	IN
cord-006702-ekf6mja9	983	19	1	1	CD
cord-006702-ekf6mja9	983	20	year	year	NN
cord-006702-ekf6mja9	983	21	.	.	.
cord-006702-ekf6mja9	984	1	PD	PD	NNP
cord-006702-ekf6mja9	984	2	is	be	VBZ
cord-006702-ekf6mja9	984	3	the	the	DT
cord-006702-ekf6mja9	984	4	modality	modality	NN
cord-006702-ekf6mja9	984	5	of	of	IN
cord-006702-ekf6mja9	984	6	choice	choice	NN
cord-006702-ekf6mja9	984	7	,	,	,
cord-006702-ekf6mja9	984	8	however	however	RB
cord-006702-ekf6mja9	984	9	the	the	DT
cord-006702-ekf6mja9	984	10	peritonitis	peritonitis	NN
cord-006702-ekf6mja9	984	11	rate	rate	NN
cord-006702-ekf6mja9	984	12	was	be	VBD
cord-006702-ekf6mja9	984	13	higher	high	JJR
cord-006702-ekf6mja9	984	14	than	than	IN
cord-006702-ekf6mja9	984	15	recommended	recommend	VBN
cord-006702-ekf6mja9	984	16	,	,	,
cord-006702-ekf6mja9	984	17	but	but	CC
cord-006702-ekf6mja9	984	18	may	may	MD
cord-006702-ekf6mja9	984	19	reflect	reflect	VB
cord-006702-ekf6mja9	984	20	the	the	DT
cord-006702-ekf6mja9	984	21	high	high	JJ
cord-006702-ekf6mja9	984	22	percentage	percentage	NN
cord-006702-ekf6mja9	984	23	of	of	IN
cord-006702-ekf6mja9	984	24	infants	infant	NNS
cord-006702-ekf6mja9	984	25	in	in	IN
cord-006702-ekf6mja9	984	26	this	this	DT
cord-006702-ekf6mja9	984	27	study	study	NN
cord-006702-ekf6mja9	984	28	.	.	.
cord-006702-ekf6mja9	985	1	A	a	DT
cord-006702-ekf6mja9	985	2	significant	significant	JJ
cord-006702-ekf6mja9	985	3	number	number	NN
cord-006702-ekf6mja9	985	4	switched	switch	VBN
cord-006702-ekf6mja9	985	5	between	between	IN
cord-006702-ekf6mja9	985	6	dialysis	dialysis	NN
cord-006702-ekf6mja9	985	7	modalities	modality	NNS
cord-006702-ekf6mja9	985	8	.	.	.
cord-006702-ekf6mja9	986	1	Vascular	vascular	JJ
cord-006702-ekf6mja9	986	2	access	access	NN
cord-006702-ekf6mja9	986	3	in	in	IN
cord-006702-ekf6mja9	986	4	children	child	NNS
cord-006702-ekf6mja9	986	5	on	on	IN
cord-006702-ekf6mja9	986	6	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	986	7	:	:	:
cord-006702-ekf6mja9	986	8	a	a	DT
cord-006702-ekf6mja9	986	9	report	report	NN
cord-006702-ekf6mja9	986	10	from	from	IN
cord-006702-ekf6mja9	986	11	the	the	DT
cord-006702-ekf6mja9	986	12	ESPN	ESPN	NNP
cord-006702-ekf6mja9	986	13	/	/	SYM
cord-006702-ekf6mja9	986	14	ERA	ERA	NNP
cord-006702-ekf6mja9	986	15	-	-	HYPH
cord-006702-ekf6mja9	986	16	EDTA	EDTA	NNP
cord-006702-ekf6mja9	986	17	Registry	Registry	NNP
cord-006702-ekf6mja9	986	18	M.	M.	NNP
cord-006702-ekf6mja9	986	19	Boehm	Boehm	NNP
cord-006702-ekf6mja9	986	20	(	(	-LRB-
cord-006702-ekf6mja9	986	21	1	1	CD
cord-006702-ekf6mja9	986	22	)	)	-RRB-
cord-006702-ekf6mja9	986	23	,	,	,
cord-006702-ekf6mja9	986	24	M.	M.	NNP
cord-006702-ekf6mja9	986	25	Bonthuis	Bonthuis	NNP
cord-006702-ekf6mja9	986	26	(	(	-LRB-
cord-006702-ekf6mja9	986	27	2	2	CD
cord-006702-ekf6mja9	986	28	)	)	-RRB-
cord-006702-ekf6mja9	986	29	,	,	,
cord-006702-ekf6mja9	986	30	M.	M.	NNP
cord-006702-ekf6mja9	986	31	Noordzij	Noordzij	NNP
cord-006702-ekf6mja9	986	32	(	(	-LRB-
cord-006702-ekf6mja9	986	33	2	2	CD
cord-006702-ekf6mja9	986	34	)	)	-RRB-
cord-006702-ekf6mja9	986	35	,	,	,
cord-006702-ekf6mja9	986	36	J.	J.	NNP
cord-006702-ekf6mja9	986	37	Harambat	Harambat	NNP
cord-006702-ekf6mja9	986	38	(	(	-LRB-
cord-006702-ekf6mja9	986	39	3	3	CD
cord-006702-ekf6mja9	986	40	)	)	-RRB-
cord-006702-ekf6mja9	986	41	,	,	,
cord-006702-ekf6mja9	986	42	J.	J.	NNP
cord-006702-ekf6mja9	986	43	Groothoff	Groothoff	NNP
cord-006702-ekf6mja9	986	44	(	(	-LRB-
cord-006702-ekf6mja9	986	45	4	4	CD
cord-006702-ekf6mja9	986	46	)	)	-RRB-
cord-006702-ekf6mja9	986	47	,	,	,
cord-006702-ekf6mja9	986	48	C.	C.	NNP
cord-006702-ekf6mja9	986	49	Aufricht	Aufricht	NNP
cord-006702-ekf6mja9	986	50	(	(	-LRB-
cord-006702-ekf6mja9	986	51	1	1	CD
cord-006702-ekf6mja9	986	52	)	)	-RRB-
cord-006702-ekf6mja9	986	53	,	,	,
cord-006702-ekf6mja9	986	54	K.	K.	NNP
cord-006702-ekf6mja9	986	55	Jager	Jager	NNP
cord-006702-ekf6mja9	986	56	(	(	-LRB-
cord-006702-ekf6mja9	986	57	2	2	CD
cord-006702-ekf6mja9	986	58	)	)	-RRB-
cord-006702-ekf6mja9	986	59	,	,	,
cord-006702-ekf6mja9	986	60	F.	F.	NNP
cord-006702-ekf6mja9	986	61	Schaefer	Schaefer	NNP
cord-006702-ekf6mja9	986	62	(	(	-LRB-
cord-006702-ekf6mja9	986	63	,	,	,
cord-006702-ekf6mja9	986	64	showed	show	VBD
cord-006702-ekf6mja9	986	65	lower	low	JJR
cord-006702-ekf6mja9	986	66	hemoglobin	hemoglobin	NN
cord-006702-ekf6mja9	986	67	levels	level	NNS
cord-006702-ekf6mja9	986	68	(	(	-LRB-
cord-006702-ekf6mja9	986	69	CVC	CVC	NNP
cord-006702-ekf6mja9	986	70	:	:	:
cord-006702-ekf6mja9	986	71	9.1	9.1	CD
cord-006702-ekf6mja9	986	72	(	(	-LRB-
cord-006702-ekf6mja9	986	73	7.7	7.7	CD
cord-006702-ekf6mja9	986	74	-	-	HYPH
cord-006702-ekf6mja9	986	75	10.4	10.4	CD
cord-006702-ekf6mja9	986	76	)	)	-RRB-
cord-006702-ekf6mja9	986	77	g	g	NN
cord-006702-ekf6mja9	986	78	/	/	SYM
cord-006702-ekf6mja9	986	79	dl	dl	NN
cord-006702-ekf6mja9	986	80	;	;	:
cord-006702-ekf6mja9	986	81	AVF	AVF	NNP
cord-006702-ekf6mja9	986	82	:	:	:
cord-006702-ekf6mja9	986	83	10.4	10.4	CD
cord-006702-ekf6mja9	986	84	(	(	-LRB-
cord-006702-ekf6mja9	986	85	9.0	9.0	CD
cord-006702-ekf6mja9	986	86	-	-	SYM
cord-006702-ekf6mja9	986	87	11.8	11.8	CD
cord-006702-ekf6mja9	986	88	)	)	-RRB-
cord-006702-ekf6mja9	986	89	g	g	NN
cord-006702-ekf6mja9	986	90	/	/	SYM
cord-006702-ekf6mja9	986	91	dl	dl	NN
cord-006702-ekf6mja9	986	92	)	)	-RRB-
cord-006702-ekf6mja9	986	93	and	and	CC
cord-006702-ekf6mja9	986	94	lower	low	JJR
cord-006702-ekf6mja9	986	95	height	height	NN
cord-006702-ekf6mja9	986	96	-	-	HYPH
cord-006702-ekf6mja9	986	97	SDS	sds	NN
cord-006702-ekf6mja9	986	98	(	(	-LRB-
cord-006702-ekf6mja9	986	99	CVC	CVC	NNP
cord-006702-ekf6mja9	986	100	:	:	:
cord-006702-ekf6mja9	986	101	-1.61	-1.61	:
cord-006702-ekf6mja9	986	102	(	(	-LRB-
cord-006702-ekf6mja9	986	103	-2.67	-2.67	CD
cord-006702-ekf6mja9	986	104	;	;	:
cord-006702-ekf6mja9	986	105	-0.50	-0.50	CD
cord-006702-ekf6mja9	986	106	)	)	-RRB-
cord-006702-ekf6mja9	986	107	,	,	,
cord-006702-ekf6mja9	986	108	AVF	AVF	NNP
cord-006702-ekf6mja9	986	109	:	:	:
cord-006702-ekf6mja9	986	110	-1.35	-1.35	.
cord-006702-ekf6mja9	987	1	(	(	-LRB-
cord-006702-ekf6mja9	987	2	-2.09	-2.09	:
cord-006702-ekf6mja9	987	3	;	;	:
cord-006702-ekf6mja9	987	4	-0.31	-0.31	CD
cord-006702-ekf6mja9	987	5	)	)	-RRB-
cord-006702-ekf6mja9	987	6	at	at	IN
cord-006702-ekf6mja9	987	7	start	start	NN
cord-006702-ekf6mja9	987	8	of	of	IN
cord-006702-ekf6mja9	987	9	HD	hd	NN
cord-006702-ekf6mja9	987	10	.	.	.
cord-006702-ekf6mja9	988	1	Likelihood	likelihood	NN
cord-006702-ekf6mja9	988	2	of	of	IN
cord-006702-ekf6mja9	988	3	receiving	receive	VBG
cord-006702-ekf6mja9	988	4	an	an	DT
cord-006702-ekf6mja9	988	5	AVF	AVF	NNP
cord-006702-ekf6mja9	988	6	was	be	VBD
cord-006702-ekf6mja9	988	7	lower	low	JJR
cord-006702-ekf6mja9	988	8	for	for	IN
cord-006702-ekf6mja9	988	9	children	child	NNS
cord-006702-ekf6mja9	988	10	with	with	IN
cord-006702-ekf6mja9	988	11	Glomerulonephritis	Glomerulonephritis	NNP
cord-006702-ekf6mja9	988	12	(	(	-LRB-
cord-006702-ekf6mja9	988	13	aOR	aor	NN
cord-006702-ekf6mja9	988	14	:	:	:
cord-006702-ekf6mja9	988	15	0.50	0.50	CD
cord-006702-ekf6mja9	988	16	,	,	,
cord-006702-ekf6mja9	988	17	95	95	CD
cord-006702-ekf6mja9	988	18	%	%	NN
cord-006702-ekf6mja9	988	19	CI	ci	NN
cord-006702-ekf6mja9	988	20	:	:	:
cord-006702-ekf6mja9	988	21	0.32	0.32	CD
cord-006702-ekf6mja9	988	22	-	-	HYPH
cord-006702-ekf6mja9	988	23	0.76	0.76	CD
cord-006702-ekf6mja9	988	24	)	)	-RRB-
cord-006702-ekf6mja9	988	25	,	,	,
cord-006702-ekf6mja9	988	26	Vasculitis	Vasculitis	NNP
cord-006702-ekf6mja9	988	27	(	(	-LRB-
cord-006702-ekf6mja9	988	28	aOR	aor	NN
cord-006702-ekf6mja9	988	29	:	:	:
cord-006702-ekf6mja9	988	30	0.13	0.13	CD
cord-006702-ekf6mja9	988	31	,	,	,
cord-006702-ekf6mja9	988	32	95	95	CD
cord-006702-ekf6mja9	988	33	%	%	NN
cord-006702-ekf6mja9	988	34	CI	ci	NN
cord-006702-ekf6mja9	988	35	:	:	:
cord-006702-ekf6mja9	988	36	0.04	0.04	CD
cord-006702-ekf6mja9	988	37	-	-	SYM
cord-006702-ekf6mja9	988	38	0.47	0.47	CD
cord-006702-ekf6mja9	988	39	)	)	-RRB-
cord-006702-ekf6mja9	988	40	and	and	CC
cord-006702-ekf6mja9	988	41	missing	miss	VBG
cord-006702-ekf6mja9	988	42	or	or	CC
cord-006702-ekf6mja9	988	43	unknown	unknown	JJ
cord-006702-ekf6mja9	988	44	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	989	1	(	(	-LRB-
cord-006702-ekf6mja9	989	2	aOR	aor	NN
cord-006702-ekf6mja9	989	3	:	:	:
cord-006702-ekf6mja9	989	4	0.38	0.38	CD
cord-006702-ekf6mja9	989	5	,	,	,
cord-006702-ekf6mja9	989	6	95	95	CD
cord-006702-ekf6mja9	989	7	%	%	NN
cord-006702-ekf6mja9	989	8	CI	ci	NN
cord-006702-ekf6mja9	989	9	:	:	:
cord-006702-ekf6mja9	989	10	0.24	0.24	CD
cord-006702-ekf6mja9	989	11	-	-	SYM
cord-006702-ekf6mja9	989	12	0.62	0.62	CD
cord-006702-ekf6mja9	989	13	)	)	-RRB-
cord-006702-ekf6mja9	989	14	.	.	.
cord-006702-ekf6mja9	990	1	After	after	IN
cord-006702-ekf6mja9	990	2	two	two	CD
cord-006702-ekf6mja9	990	3	years	year	NNS
cord-006702-ekf6mja9	990	4	28.6	28.6	CD
cord-006702-ekf6mja9	990	5	%	%	NN
cord-006702-ekf6mja9	990	6	of	of	IN
cord-006702-ekf6mja9	990	7	AVF	AVF	NNP
cord-006702-ekf6mja9	990	8	patients	patient	NNS
cord-006702-ekf6mja9	990	9	and	and	CC
cord-006702-ekf6mja9	990	10	only	only	RB
cord-006702-ekf6mja9	990	11	17.9	17.9	CD
cord-006702-ekf6mja9	990	12	%	%	NN
cord-006702-ekf6mja9	990	13	of	of	IN
cord-006702-ekf6mja9	990	14	CVC	CVC	NNP
cord-006702-ekf6mja9	990	15	patients	patient	NNS
cord-006702-ekf6mja9	990	16	were	be	VBD
cord-006702-ekf6mja9	990	17	still	still	RB
cord-006702-ekf6mja9	990	18	treated	treat	VBN
cord-006702-ekf6mja9	990	19	with	with	IN
cord-006702-ekf6mja9	990	20	their	-PRON-	PRP$
cord-006702-ekf6mja9	990	21	initial	initial	JJ
cord-006702-ekf6mja9	990	22	vascular	vascular	JJ
cord-006702-ekf6mja9	990	23	access	access	NN
cord-006702-ekf6mja9	990	24	.	.	.
cord-006702-ekf6mja9	991	1	The	the	DT
cord-006702-ekf6mja9	991	2	overall	overall	JJ
cord-006702-ekf6mja9	991	3	likelihood	likelihood	NN
cord-006702-ekf6mja9	991	4	of	of	IN
cord-006702-ekf6mja9	991	5	receiving	receive	VBG
cord-006702-ekf6mja9	991	6	a	a	DT
cord-006702-ekf6mja9	991	7	renal	renal	JJ
cord-006702-ekf6mja9	991	8	transplant	transplant	NN
cord-006702-ekf6mja9	991	9	within	within	IN
cord-006702-ekf6mja9	991	10	two	two	CD
cord-006702-ekf6mja9	991	11	years	year	NNS
cord-006702-ekf6mja9	991	12	was	be	VBD
cord-006702-ekf6mja9	991	13	not	not	RB
cord-006702-ekf6mja9	991	14	different	different	JJ
cord-006702-ekf6mja9	991	15	,	,	,
cord-006702-ekf6mja9	991	16	children	child	NNS
cord-006702-ekf6mja9	991	17	who	who	WP
cord-006702-ekf6mja9	991	18	received	receive	VBD
cord-006702-ekf6mja9	991	19	LD	LD	NNP
cord-006702-ekf6mja9	991	20	were	be	VBD
cord-006702-ekf6mja9	991	21	more	more	RBR
cord-006702-ekf6mja9	991	22	frequently	frequently	RB
cord-006702-ekf6mja9	991	23	started	start	VBN
cord-006702-ekf6mja9	991	24	with	with	IN
cord-006702-ekf6mja9	991	25	CVC	CVC	NNP
cord-006702-ekf6mja9	991	26	(	(	-LRB-
cord-006702-ekf6mja9	991	27	aHR	aHR	NNS
cord-006702-ekf6mja9	991	28	:	:	:
cord-006702-ekf6mja9	991	29	1.60	1.60	CD
cord-006702-ekf6mja9	991	30	,	,	,
cord-006702-ekf6mja9	991	31	95	95	CD
cord-006702-ekf6mja9	991	32	%	%	NN
cord-006702-ekf6mja9	991	33	CI	ci	NN
cord-006702-ekf6mja9	991	34	:	:	:
cord-006702-ekf6mja9	991	35	1.19	1.19	CD
cord-006702-ekf6mja9	991	36	-	-	SYM
cord-006702-ekf6mja9	991	37	2.14	2.14	CD
cord-006702-ekf6mja9	991	38	)	)	-RRB-
cord-006702-ekf6mja9	991	39	.	.	.
cord-006702-ekf6mja9	992	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	992	2	:	:	:
cord-006702-ekf6mja9	993	1	In	in	IN
cord-006702-ekf6mja9	993	2	conflict	conflict	NN
cord-006702-ekf6mja9	993	3	with	with	IN
cord-006702-ekf6mja9	993	4	the	the	DT
cord-006702-ekf6mja9	993	5	KDOQI	KDOQI	NNP
cord-006702-ekf6mja9	993	6	recommendations	recommendation	NNS
cord-006702-ekf6mja9	993	7	,	,	,
cord-006702-ekf6mja9	993	8	CVC	CVC	NNP
cord-006702-ekf6mja9	993	9	is	be	VBZ
cord-006702-ekf6mja9	993	10	the	the	DT
cord-006702-ekf6mja9	993	11	most	most	RBS
cord-006702-ekf6mja9	993	12	often	often	RB
cord-006702-ekf6mja9	993	13	applied	apply	VBN
cord-006702-ekf6mja9	993	14	type	type	NN
cord-006702-ekf6mja9	993	15	of	of	IN
cord-006702-ekf6mja9	993	16	vascular	vascular	JJ
cord-006702-ekf6mja9	993	17	access	access	NN
cord-006702-ekf6mja9	993	18	in	in	IN
cord-006702-ekf6mja9	993	19	children	child	NNS
cord-006702-ekf6mja9	993	20	who	who	WP
cord-006702-ekf6mja9	993	21	start	start	VBP
cord-006702-ekf6mja9	993	22	with	with	IN
cord-006702-ekf6mja9	993	23	HD	hd	NN
cord-006702-ekf6mja9	993	24	,	,	,
cord-006702-ekf6mja9	993	25	despite	despite	IN
cord-006702-ekf6mja9	993	26	the	the	DT
cord-006702-ekf6mja9	993	27	significantly	significantly	RB
cord-006702-ekf6mja9	993	28	higher	high	JJR
cord-006702-ekf6mja9	993	29	need	need	NN
cord-006702-ekf6mja9	993	30	for	for	IN
cord-006702-ekf6mja9	993	31	a	a	DT
cord-006702-ekf6mja9	993	32	second	second	JJ
cord-006702-ekf6mja9	993	33	vascular	vascular	JJ
cord-006702-ekf6mja9	993	34	access	access	NN
cord-006702-ekf6mja9	993	35	.	.	.
cord-006702-ekf6mja9	994	1	The	the	DT
cord-006702-ekf6mja9	994	2	higher	high	JJR
cord-006702-ekf6mja9	994	3	number	number	NN
cord-006702-ekf6mja9	994	4	of	of	IN
cord-006702-ekf6mja9	994	5	LD	LD	NNP
cord-006702-ekf6mja9	994	6	in	in	IN
cord-006702-ekf6mja9	994	7	CVC	CVC	NNP
cord-006702-ekf6mja9	994	8	children	child	NNS
cord-006702-ekf6mja9	994	9	suggests	suggest	VBZ
cord-006702-ekf6mja9	994	10	a	a	DT
cord-006702-ekf6mja9	994	11	conscious	conscious	JJ
cord-006702-ekf6mja9	994	12	policy	policy	NN
cord-006702-ekf6mja9	994	13	,	,	,
cord-006702-ekf6mja9	994	14	which	which	WDT
cord-006702-ekf6mja9	994	15	should	should	MD
cord-006702-ekf6mja9	994	16	be	be	VB
cord-006702-ekf6mja9	994	17	reconsidered	reconsider	VBN
cord-006702-ekf6mja9	994	18	,	,	,
cord-006702-ekf6mja9	994	19	as	as	IN
cord-006702-ekf6mja9	994	20	the	the	DT
cord-006702-ekf6mja9	994	21	overall	overall	JJ
cord-006702-ekf6mja9	994	22	waiting	wait	VBG
cord-006702-ekf6mja9	994	23	time	time	NN
cord-006702-ekf6mja9	994	24	for	for	IN
cord-006702-ekf6mja9	994	25	transplantation	transplantation	NN
cord-006702-ekf6mja9	994	26	is	be	VBZ
cord-006702-ekf6mja9	994	27	equal	equal	JJ
cord-006702-ekf6mja9	994	28	in	in	IN
cord-006702-ekf6mja9	994	29	both	both	DT
cord-006702-ekf6mja9	994	30	groups	group	NNS
cord-006702-ekf6mja9	994	31	of	of	IN
cord-006702-ekf6mja9	994	32	patients	patient	NNS
cord-006702-ekf6mja9	994	33	.	.	.
cord-006702-ekf6mja9	995	1	Genetic	genetic	JJ
cord-006702-ekf6mja9	995	2	and	and	CC
cord-006702-ekf6mja9	995	3	clinical	clinical	JJ
cord-006702-ekf6mja9	995	4	characteristics	characteristic	NNS
cord-006702-ekf6mja9	995	5	of	of	IN
cord-006702-ekf6mja9	995	6	female	female	JJ
cord-006702-ekf6mja9	995	7	X	x	NN
cord-006702-ekf6mja9	995	8	-	-	HYPH
cord-006702-ekf6mja9	995	9	linked	link	VBN
cord-006702-ekf6mja9	995	10	Alport	Alport	NNP
cord-006702-ekf6mja9	995	11	syndrome	syndrome	NN
cord-006702-ekf6mja9	996	1	:	:	:
cord-006702-ekf6mja9	996	2	267	267	CD
cord-006702-ekf6mja9	996	3	cases	case	NNS
cord-006702-ekf6mja9	996	4	study	study	VBP
cord-006702-ekf6mja9	996	5	T.	T.	NNP
cord-006702-ekf6mja9	996	6	Yamamura	Yamamura	NNP
cord-006702-ekf6mja9	996	7	(	(	-LRB-
cord-006702-ekf6mja9	996	8	1	1	CD
cord-006702-ekf6mja9	996	9	)	)	-RRB-
cord-006702-ekf6mja9	996	10	,	,	,
cord-006702-ekf6mja9	996	11	K.	K.	NNP
cord-006702-ekf6mja9	996	12	Nozu	Nozu	NNP
cord-006702-ekf6mja9	996	13	(	(	-LRB-
cord-006702-ekf6mja9	996	14	1	1	CD
cord-006702-ekf6mja9	996	15	)	)	-RRB-
cord-006702-ekf6mja9	996	16	,	,	,
cord-006702-ekf6mja9	996	17	K.	K.	NNP
cord-006702-ekf6mja9	996	18	Nakanishi	Nakanishi	NNP
cord-006702-ekf6mja9	996	19	(	(	-LRB-
cord-006702-ekf6mja9	996	20	1	1	CD
cord-006702-ekf6mja9	996	21	)	)	-RRB-
cord-006702-ekf6mja9	996	22	,	,	,
cord-006702-ekf6mja9	996	23	S.	S.	NNP
cord-006702-ekf6mja9	996	24	Minamikawa	Minamikawa	NNP
cord-006702-ekf6mja9	996	25	(	(	-LRB-
cord-006702-ekf6mja9	996	26	1	1	CD
cord-006702-ekf6mja9	996	27	)	)	-RRB-
cord-006702-ekf6mja9	996	28	,	,	,
cord-006702-ekf6mja9	996	29	T.	T.	NNP
cord-006702-ekf6mja9	996	30	Ninchoji	Ninchoji	NNP
cord-006702-ekf6mja9	996	31	(	(	-LRB-
cord-006702-ekf6mja9	996	32	1	1	CD
cord-006702-ekf6mja9	996	33	)	)	-RRB-
cord-006702-ekf6mja9	996	34	,	,	,
cord-006702-ekf6mja9	996	35	K.	K.	NNP
cord-006702-ekf6mja9	996	36	Nakanishi	Nakanishi	NNP
cord-006702-ekf6mja9	996	37	(	(	-LRB-
cord-006702-ekf6mja9	996	38	2	2	CD
cord-006702-ekf6mja9	996	39	)	)	-RRB-
cord-006702-ekf6mja9	996	40	,	,	,
cord-006702-ekf6mja9	996	41	N.	N.	NNP
cord-006702-ekf6mja9	996	42	Yoshikawa	Yoshikawa	NNP
cord-006702-ekf6mja9	996	43	(	(	-LRB-
cord-006702-ekf6mja9	996	44	3	3	CD
cord-006702-ekf6mja9	996	45	)	)	-RRB-
cord-006702-ekf6mja9	996	46	,	,	,
cord-006702-ekf6mja9	996	47	K.	K.	NNP
cord-006702-ekf6mja9	996	48	Iijima	Iijima	NNP
cord-006702-ekf6mja9	996	49	(	(	-LRB-
cord-006702-ekf6mja9	996	50	1	1	CD
cord-006702-ekf6mja9	996	51	)	)	-RRB-
cord-006702-ekf6mja9	997	1	(	(	-LRB-
cord-006702-ekf6mja9	997	2	1	1	LS
cord-006702-ekf6mja9	997	3	)	)	-RRB-
cord-006702-ekf6mja9	997	4	Kobe	Kobe	NNP
cord-006702-ekf6mja9	997	5	University	University	NNP
cord-006702-ekf6mja9	997	6	Graduate	Graduate	NNP
cord-006702-ekf6mja9	997	7	School	School	NNP
cord-006702-ekf6mja9	997	8	of	of	IN
cord-006702-ekf6mja9	997	9	Medicine	Medicine	NNP
cord-006702-ekf6mja9	997	10	,	,	,
cord-006702-ekf6mja9	997	11	Kobe	Kobe	NNP
cord-006702-ekf6mja9	997	12	,	,	,
cord-006702-ekf6mja9	997	13	Japan	Japan	NNP
cord-006702-ekf6mja9	997	14	;	;	:
cord-006702-ekf6mja9	997	15	(	(	-LRB-
cord-006702-ekf6mja9	997	16	2	2	LS
cord-006702-ekf6mja9	997	17	)	)	-RRB-
cord-006702-ekf6mja9	997	18	Department	Department	NNP
cord-006702-ekf6mja9	997	19	of	of	IN
cord-006702-ekf6mja9	997	20	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	997	21	,	,	,
cord-006702-ekf6mja9	997	22	Wakayama	Wakayama	NNP
cord-006702-ekf6mja9	997	23	Medical	Medical	NNP
cord-006702-ekf6mja9	997	24	University	University	NNP
cord-006702-ekf6mja9	997	25	,	,	,
cord-006702-ekf6mja9	997	26	Wakayama	Wakayama	NNP
cord-006702-ekf6mja9	997	27	,	,	,
cord-006702-ekf6mja9	997	28	Japan	Japan	NNP
cord-006702-ekf6mja9	997	29	;	;	:
cord-006702-ekf6mja9	997	30	(	(	-LRB-
cord-006702-ekf6mja9	997	31	3	3	LS
cord-006702-ekf6mja9	997	32	)	)	-RRB-
cord-006702-ekf6mja9	997	33	National	National	NNP
cord-006702-ekf6mja9	997	34	Center	Center	NNP
cord-006702-ekf6mja9	997	35	for	for	IN
cord-006702-ekf6mja9	997	36	Children	Children	NNP
cord-006702-ekf6mja9	997	37	Health	Health	NNP
cord-006702-ekf6mja9	997	38	and	and	CC
cord-006702-ekf6mja9	997	39	Development	Development	NNP
cord-006702-ekf6mja9	997	40	,	,	,
cord-006702-ekf6mja9	997	41	Tokyo	Tokyo	NNP
cord-006702-ekf6mja9	998	1	,	,	,
cord-006702-ekf6mja9	998	2	Japan	Japan	NNP
cord-006702-ekf6mja9	998	3	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	998	4	:	:	:
cord-006702-ekf6mja9	998	5	The	the	DT
cord-006702-ekf6mja9	998	6	aims	aim	NNS
cord-006702-ekf6mja9	998	7	of	of	IN
cord-006702-ekf6mja9	998	8	this	this	DT
cord-006702-ekf6mja9	998	9	study	study	NN
cord-006702-ekf6mja9	998	10	are	be	VBP
cord-006702-ekf6mja9	998	11	to	to	TO
cord-006702-ekf6mja9	998	12	clarify	clarify	VB
cord-006702-ekf6mja9	998	13	the	the	DT
cord-006702-ekf6mja9	998	14	genetic	genetic	JJ
cord-006702-ekf6mja9	998	15	and	and	CC
cord-006702-ekf6mja9	998	16	clinical	clinical	JJ
cord-006702-ekf6mja9	998	17	characteristics	characteristic	NNS
cord-006702-ekf6mja9	998	18	of	of	IN
cord-006702-ekf6mja9	998	19	the	the	DT
cord-006702-ekf6mja9	998	20	large	large	JJ
cord-006702-ekf6mja9	998	21	number	number	NN
cord-006702-ekf6mja9	998	22	of	of	IN
cord-006702-ekf6mja9	998	23	female	female	JJ
cord-006702-ekf6mja9	998	24	X	x	NN
cord-006702-ekf6mja9	998	25	-	-	HYPH
cord-006702-ekf6mja9	998	26	linked	link	VBN
cord-006702-ekf6mja9	998	27	Alport	Alport	NNP
cord-006702-ekf6mja9	998	28	syndrome	syndrome	NN
cord-006702-ekf6mja9	998	29	(	(	-LRB-
cord-006702-ekf6mja9	998	30	XLAS	XLAS	NNP
cord-006702-ekf6mja9	998	31	)	)	-RRB-
cord-006702-ekf6mja9	998	32	patients	patient	NNS
cord-006702-ekf6mja9	998	33	in	in	IN
cord-006702-ekf6mja9	998	34	Japan	Japan	NNP
cord-006702-ekf6mja9	998	35	and	and	CC
cord-006702-ekf6mja9	998	36	the	the	DT
cord-006702-ekf6mja9	998	37	contribution	contribution	NN
cord-006702-ekf6mja9	998	38	of	of	IN
cord-006702-ekf6mja9	998	39	skewed	skewed	JJ
cord-006702-ekf6mja9	998	40	X	x	NN
cord-006702-ekf6mja9	998	41	inactivation	inactivation	NN
cord-006702-ekf6mja9	998	42	to	to	IN
cord-006702-ekf6mja9	998	43	disease	disease	NN
cord-006702-ekf6mja9	998	44	severity	severity	NN
cord-006702-ekf6mja9	998	45	.	.	.
cord-006702-ekf6mja9	999	1	Methods	method	NNS
cord-006702-ekf6mja9	999	2	:	:	:
cord-006702-ekf6mja9	999	3	We	-PRON-	PRP
cord-006702-ekf6mja9	999	4	conducted	conduct	VBD
cord-006702-ekf6mja9	999	5	a	a	DT
cord-006702-ekf6mja9	999	6	retrospective	retrospective	JJ
cord-006702-ekf6mja9	999	7	analysis	analysis	NN
cord-006702-ekf6mja9	999	8	for	for	IN
cord-006702-ekf6mja9	999	9	267	267	CD
cord-006702-ekf6mja9	999	10	female	female	JJ
cord-006702-ekf6mja9	999	11	patients	patient	NNS
cord-006702-ekf6mja9	999	12	in	in	IN
cord-006702-ekf6mja9	999	13	173	173	CD
cord-006702-ekf6mja9	999	14	families	family	NNS
cord-006702-ekf6mja9	999	15	who	who	WP
cord-006702-ekf6mja9	999	16	were	be	VBD
cord-006702-ekf6mja9	999	17	genetically	genetically	RB
cord-006702-ekf6mja9	999	18	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	999	19	with	with	IN
cord-006702-ekf6mja9	999	20	X	x	NN
cord-006702-ekf6mja9	999	21	-	-	HYPH
cord-006702-ekf6mja9	999	22	linked	link	VBN
cord-006702-ekf6mja9	999	23	Alport	Alport	NNP
cord-006702-ekf6mja9	999	24	syndrome	syndrome	NN
cord-006702-ekf6mja9	999	25	in	in	IN
cord-006702-ekf6mja9	999	26	our	-PRON-	PRP$
cord-006702-ekf6mja9	999	27	department	department	NN
cord-006702-ekf6mja9	999	28	.	.	.
cord-006702-ekf6mja9	1000	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1000	2	analyzed	analyze	VBD
cord-006702-ekf6mja9	1000	3	clinical	clinical	JJ
cord-006702-ekf6mja9	1000	4	and	and	CC
cord-006702-ekf6mja9	1000	5	laboratory	laboratory	NN
cord-006702-ekf6mja9	1000	6	data	datum	NNS
cord-006702-ekf6mja9	1000	7	from	from	IN
cord-006702-ekf6mja9	1000	8	medical	medical	JJ
cord-006702-ekf6mja9	1000	9	records	record	NNS
cord-006702-ekf6mja9	1000	10	.	.	.
cord-006702-ekf6mja9	1001	1	The	the	DT
cord-006702-ekf6mja9	1001	2	data	datum	NNS
cord-006702-ekf6mja9	1001	3	included	include	VBD
cord-006702-ekf6mja9	1001	4	proportion	proportion	NN
cord-006702-ekf6mja9	1001	5	of	of	IN
cord-006702-ekf6mja9	1001	6	patients	patient	NNS
cord-006702-ekf6mja9	1001	7	with	with	IN
cord-006702-ekf6mja9	1001	8	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1001	9	and	and	CC
cord-006702-ekf6mja9	1001	10	the	the	DT
cord-006702-ekf6mja9	1001	11	age	age	NN
cord-006702-ekf6mja9	1001	12	at	at	IN
cord-006702-ekf6mja9	1001	13	which	which	WDT
cord-006702-ekf6mja9	1001	14	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1001	15	was	be	VBD
cord-006702-ekf6mja9	1001	16	detected	detect	VBN
cord-006702-ekf6mja9	1001	17	,	,	,
cord-006702-ekf6mja9	1001	18	proportion	proportion	NN
cord-006702-ekf6mja9	1001	19	of	of	IN
cord-006702-ekf6mja9	1001	20	patients	patient	NNS
cord-006702-ekf6mja9	1001	21	with	with	IN
cord-006702-ekf6mja9	1001	22	end	end	NN
cord-006702-ekf6mja9	1001	23	-	-	HYPH
cord-006702-ekf6mja9	1001	24	stage	stage	NN
cord-006702-ekf6mja9	1001	25	renal	renal	JJ
cord-006702-ekf6mja9	1001	26	disease	disease	NN
cord-006702-ekf6mja9	1001	27	(	(	-LRB-
cord-006702-ekf6mja9	1001	28	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1001	29	)	)	-RRB-
cord-006702-ekf6mja9	1001	30	and	and	CC
cord-006702-ekf6mja9	1001	31	the	the	DT
cord-006702-ekf6mja9	1001	32	age	age	NN
cord-006702-ekf6mja9	1001	33	at	at	IN
cord-006702-ekf6mja9	1001	34	which	which	WDT
cord-006702-ekf6mja9	1001	35	they	-PRON-	PRP
cord-006702-ekf6mja9	1001	36	reached	reach	VBD
cord-006702-ekf6mja9	1001	37	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1001	38	,	,	,
cord-006702-ekf6mja9	1001	39	hearing	hear	VBG
cord-006702-ekf6mja9	1001	40	loss	loss	NN
cord-006702-ekf6mja9	1001	41	and	and	CC
cord-006702-ekf6mja9	1001	42	specific	specific	JJ
cord-006702-ekf6mja9	1001	43	ocular	ocular	JJ
cord-006702-ekf6mja9	1001	44	changes	change	NNS
cord-006702-ekf6mja9	1001	45	,	,	,
cord-006702-ekf6mja9	1001	46	genotype	genotype	NN
cord-006702-ekf6mja9	1001	47	-	-	HYPH
cord-006702-ekf6mja9	1001	48	phenotype	phenotype	NN
cord-006702-ekf6mja9	1001	49	correlation	correlation	NN
cord-006702-ekf6mja9	1001	50	.	.	.
cord-006702-ekf6mja9	1002	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1002	2	also	also	RB
cord-006702-ekf6mja9	1002	3	performed	perform	VBD
cord-006702-ekf6mja9	1002	4	a	a	DT
cord-006702-ekf6mja9	1002	5	X	x	NN
cord-006702-ekf6mja9	1002	6	-	-	NN
cord-006702-ekf6mja9	1002	7	inactivation	inactivation	JJ
cord-006702-ekf6mja9	1002	8	analysis	analysis	NN
cord-006702-ekf6mja9	1002	9	for	for	IN
cord-006702-ekf6mja9	1002	10	the	the	DT
cord-006702-ekf6mja9	1002	11	severe	severe	JJ
cord-006702-ekf6mja9	1002	12	patients	patient	NNS
cord-006702-ekf6mja9	1002	13	who	who	WP
cord-006702-ekf6mja9	1002	14	reached	reach	VBD
cord-006702-ekf6mja9	1002	15	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1002	16	before	before	IN
cord-006702-ekf6mja9	1002	17	age	age	NN
cord-006702-ekf6mja9	1002	18	60	60	CD
cord-006702-ekf6mja9	1002	19	.	.	.
cord-006702-ekf6mja9	1003	1	Results	result	NNS
cord-006702-ekf6mja9	1003	2	:	:	:
cord-006702-ekf6mja9	1004	1	The	the	DT
cord-006702-ekf6mja9	1004	2	median	median	JJ
cord-006702-ekf6mja9	1004	3	age	age	NN
cord-006702-ekf6mja9	1004	4	of	of	IN
cord-006702-ekf6mja9	1004	5	our	-PRON-	PRP$
cord-006702-ekf6mja9	1004	6	cohort	cohort	NN
cord-006702-ekf6mja9	1004	7	was	be	VBD
cord-006702-ekf6mja9	1004	8	24	24	CD
cord-006702-ekf6mja9	1004	9	years	year	NNS
cord-006702-ekf6mja9	1004	10	(	(	-LRB-
cord-006702-ekf6mja9	1004	11	age	age	NN
cord-006702-ekf6mja9	1004	12	from	from	IN
cord-006702-ekf6mja9	1004	13	0	0	CD
cord-006702-ekf6mja9	1004	14	to	to	IN
cord-006702-ekf6mja9	1004	15	92	92	CD
cord-006702-ekf6mja9	1004	16	years	year	NNS
cord-006702-ekf6mja9	1004	17	)	)	-RRB-
cord-006702-ekf6mja9	1004	18	.	.	.
cord-006702-ekf6mja9	1005	1	Proteinuria	Proteinuria	NNP
cord-006702-ekf6mja9	1005	2	was	be	VBD
cord-006702-ekf6mja9	1005	3	detected	detect	VBN
cord-006702-ekf6mja9	1005	4	in	in	IN
cord-006702-ekf6mja9	1005	5	169	169	CD
cord-006702-ekf6mja9	1005	6	patients	patient	NNS
cord-006702-ekf6mja9	1005	7	(	(	-LRB-
cord-006702-ekf6mja9	1005	8	72.2	72.2	CD
cord-006702-ekf6mja9	1005	9	%	%	NN
cord-006702-ekf6mja9	1005	10	)	)	-RRB-
cord-006702-ekf6mja9	1005	11	and	and	CC
cord-006702-ekf6mja9	1005	12	the	the	DT
cord-006702-ekf6mja9	1005	13	median	median	JJ
cord-006702-ekf6mja9	1005	14	age	age	NN
cord-006702-ekf6mja9	1005	15	developing	develop	VBG
cord-006702-ekf6mja9	1005	16	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1005	17	was	be	VBD
cord-006702-ekf6mja9	1005	18	7.0	7.0	CD
cord-006702-ekf6mja9	1005	19	years	year	NNS
cord-006702-ekf6mja9	1005	20	.	.	.
cord-006702-ekf6mja9	1006	1	35	35	CD
cord-006702-ekf6mja9	1006	2	patients	patient	NNS
cord-006702-ekf6mja9	1006	3	reached	reach	VBD
cord-006702-ekf6mja9	1006	4	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1006	5	and	and	CC
cord-006702-ekf6mja9	1006	6	the	the	DT
cord-006702-ekf6mja9	1006	7	median	median	JJ
cord-006702-ekf6mja9	1006	8	renal	renal	JJ
cord-006702-ekf6mja9	1006	9	survival	survival	NN
cord-006702-ekf6mja9	1006	10	period	period	NN
cord-006702-ekf6mja9	1006	11	in	in	IN
cord-006702-ekf6mja9	1006	12	this	this	DT
cord-006702-ekf6mja9	1006	13	study	study	NN
cord-006702-ekf6mja9	1006	14	was	be	VBD
cord-006702-ekf6mja9	1006	15	65.0	65.0	CD
cord-006702-ekf6mja9	1006	16	years	year	NNS
cord-006702-ekf6mja9	1006	17	and	and	CC
cord-006702-ekf6mja9	1006	18	15	15	CD
cord-006702-ekf6mja9	1006	19	%	%	NN
cord-006702-ekf6mja9	1006	20	patients	patient	NNS
cord-006702-ekf6mja9	1006	21	reached	reach	VBD
cord-006702-ekf6mja9	1006	22	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1006	23	at	at	IN
cord-006702-ekf6mja9	1006	24	the	the	DT
cord-006702-ekf6mja9	1006	25	age	age	NN
cord-006702-ekf6mja9	1006	26	of	of	IN
cord-006702-ekf6mja9	1006	27	40	40	CD
cord-006702-ekf6mja9	1006	28	.	.	.
cord-006702-ekf6mja9	1007	1	Specific	specific	JJ
cord-006702-ekf6mja9	1007	2	ocular	ocular	JJ
cord-006702-ekf6mja9	1007	3	changes	change	NNS
cord-006702-ekf6mja9	1007	4	were	be	VBD
cord-006702-ekf6mja9	1007	5	detected	detect	VBN
cord-006702-ekf6mja9	1007	6	in	in	IN
cord-006702-ekf6mja9	1007	7	only	only	RB
cord-006702-ekf6mja9	1007	8	4	4	CD
cord-006702-ekf6mja9	1007	9	patients	patient	NNS
cord-006702-ekf6mja9	1007	10	and	and	CC
cord-006702-ekf6mja9	1007	11	hearing	hear	VBG
cord-006702-ekf6mja9	1007	12	loss	loss	NN
cord-006702-ekf6mja9	1007	13	was	be	VBD
cord-006702-ekf6mja9	1007	14	17	17	CD
cord-006702-ekf6mja9	1007	15	patients	patient	NNS
cord-006702-ekf6mja9	1007	16	.	.	.
cord-006702-ekf6mja9	1008	1	No	no	DT
cord-006702-ekf6mja9	1008	2	obvious	obvious	JJ
cord-006702-ekf6mja9	1008	3	genotype	genotype	NN
cord-006702-ekf6mja9	1008	4	-	-	HYPH
cord-006702-ekf6mja9	1008	5	phenotype	phenotype	NN
cord-006702-ekf6mja9	1008	6	correlation	correlation	NN
cord-006702-ekf6mja9	1008	7	was	be	VBD
cord-006702-ekf6mja9	1008	8	observed	observe	VBN
cord-006702-ekf6mja9	1008	9	.	.	.
cord-006702-ekf6mja9	1009	1	X	x	NN
cord-006702-ekf6mja9	1009	2	inactivation	inactivation	NN
cord-006702-ekf6mja9	1009	3	analysis	analysis	NN
cord-006702-ekf6mja9	1009	4	was	be	VBD
cord-006702-ekf6mja9	1009	5	held	hold	VBN
cord-006702-ekf6mja9	1009	6	to	to	IN
cord-006702-ekf6mja9	1009	7	13	13	CD
cord-006702-ekf6mja9	1009	8	severe	severe	JJ
cord-006702-ekf6mja9	1009	9	patients	patient	NNS
cord-006702-ekf6mja9	1009	10	,	,	,
cord-006702-ekf6mja9	1009	11	but	but	CC
cord-006702-ekf6mja9	1009	12	skewed	skewed	JJ
cord-006702-ekf6mja9	1009	13	X	x	NN
cord-006702-ekf6mja9	1009	14	inactivation	inactivation	NN
cord-006702-ekf6mja9	1009	15	was	be	VBD
cord-006702-ekf6mja9	1009	16	detected	detect	VBN
cord-006702-ekf6mja9	1009	17	in	in	IN
cord-006702-ekf6mja9	1009	18	only	only	RB
cord-006702-ekf6mja9	1009	19	one	one	CD
cord-006702-ekf6mja9	1009	20	patient	patient	NN
cord-006702-ekf6mja9	1009	21	and	and	CC
cord-006702-ekf6mja9	1009	22	its	-PRON-	PRP$
cord-006702-ekf6mja9	1009	23	contribution	contribution	NN
cord-006702-ekf6mja9	1009	24	to	to	IN
cord-006702-ekf6mja9	1009	25	disease	disease	NN
cord-006702-ekf6mja9	1009	26	severity	severity	NN
cord-006702-ekf6mja9	1009	27	was	be	VBD
cord-006702-ekf6mja9	1009	28	unclear	unclear	JJ
cord-006702-ekf6mja9	1009	29	.	.	.
cord-006702-ekf6mja9	1010	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1010	2	:	:	:
cord-006702-ekf6mja9	1011	1	Phenotype	phenotype	NN
cord-006702-ekf6mja9	1011	2	of	of	IN
cord-006702-ekf6mja9	1011	3	female	female	JJ
cord-006702-ekf6mja9	1011	4	XLAS	XLAS	NNP
cord-006702-ekf6mja9	1011	5	patients	patient	NNS
cord-006702-ekf6mja9	1011	6	is	be	VBZ
cord-006702-ekf6mja9	1011	7	not	not	RB
cord-006702-ekf6mja9	1011	8	always	always	RB
cord-006702-ekf6mja9	1011	9	mild	mild	JJ
cord-006702-ekf6mja9	1011	10	.	.	.
cord-006702-ekf6mja9	1012	1	Therefore	therefore	RB
cord-006702-ekf6mja9	1012	2	clinicians	clinician	NNS
cord-006702-ekf6mja9	1012	3	have	have	VBP
cord-006702-ekf6mja9	1012	4	to	to	TO
cord-006702-ekf6mja9	1012	5	pay	pay	VB
cord-006702-ekf6mja9	1012	6	attention	attention	NN
cord-006702-ekf6mja9	1012	7	to	to	IN
cord-006702-ekf6mja9	1012	8	their	-PRON-	PRP$
cord-006702-ekf6mja9	1012	9	clinical	clinical	JJ
cord-006702-ekf6mja9	1012	10	course	course	NN
cord-006702-ekf6mja9	1012	11	and	and	CC
cord-006702-ekf6mja9	1012	12	treatment	treatment	NN
cord-006702-ekf6mja9	1012	13	.	.	.
cord-006702-ekf6mja9	1013	1	There	there	EX
cord-006702-ekf6mja9	1013	2	is	be	VBZ
cord-006702-ekf6mja9	1013	3	no	no	DT
cord-006702-ekf6mja9	1013	4	genotype	genotype	NN
cord-006702-ekf6mja9	1013	5	-	-	HYPH
cord-006702-ekf6mja9	1013	6	phenotype	phenotype	NN
cord-006702-ekf6mja9	1013	7	correlation	correlation	NN
cord-006702-ekf6mja9	1013	8	and	and	CC
cord-006702-ekf6mja9	1013	9	the	the	DT
cord-006702-ekf6mja9	1013	10	contribution	contribution	NN
cord-006702-ekf6mja9	1013	11	of	of	IN
cord-006702-ekf6mja9	1013	12	Xinactivation	Xinactivation	NNP
cord-006702-ekf6mja9	1013	13	to	to	IN
cord-006702-ekf6mja9	1013	14	disease	disease	NN
cord-006702-ekf6mja9	1013	15	severity	severity	NN
cord-006702-ekf6mja9	1013	16	is	be	VBZ
cord-006702-ekf6mja9	1013	17	still	still	RB
cord-006702-ekf6mja9	1013	18	unclear	unclear	JJ
cord-006702-ekf6mja9	1013	19	.	.	.
cord-006702-ekf6mja9	1014	1	It	-PRON-	PRP
cord-006702-ekf6mja9	1014	2	is	be	VBZ
cord-006702-ekf6mja9	1014	3	assumed	assume	VBN
cord-006702-ekf6mja9	1014	4	that	that	IN
cord-006702-ekf6mja9	1014	5	the	the	DT
cord-006702-ekf6mja9	1014	6	mechanism	mechanism	NN
cord-006702-ekf6mja9	1014	7	of	of	IN
cord-006702-ekf6mja9	1014	8	determining	determine	VBG
cord-006702-ekf6mja9	1014	9	severity	severity	NN
cord-006702-ekf6mja9	1014	10	of	of	IN
cord-006702-ekf6mja9	1014	11	female	female	JJ
cord-006702-ekf6mja9	1014	12	XLAS	xla	NNS
cord-006702-ekf6mja9	1014	13	remain	remain	VBP
cord-006702-ekf6mja9	1014	14	multifactorial	multifactorial	JJ
cord-006702-ekf6mja9	1014	15	.	.	.
cord-006702-ekf6mja9	1015	1	were	be	VBD
cord-006702-ekf6mja9	1015	2	excluded	exclude	VBN
cord-006702-ekf6mja9	1015	3	.	.	.
cord-006702-ekf6mja9	1016	1	Following	follow	VBG
cord-006702-ekf6mja9	1016	2	therapy	therapy	NN
cord-006702-ekf6mja9	1016	3	of	of	IN
cord-006702-ekf6mja9	1016	4	relapse	relapse	NN
cord-006702-ekf6mja9	1016	5	,	,	,
cord-006702-ekf6mja9	1016	6	prednisone	prednisone	NNP
cord-006702-ekf6mja9	1016	7	was	be	VBD
cord-006702-ekf6mja9	1016	8	tapered	taper	VBN
cord-006702-ekf6mja9	1016	9	to	to	IN
cord-006702-ekf6mja9	1016	10	0.7	0.7	CD
cord-006702-ekf6mja9	1016	11	mg	mg	NNP
cord-006702-ekf6mja9	1016	12	/	/	SYM
cord-006702-ekf6mja9	1016	13	kg	kg	NN
cord-006702-ekf6mja9	1016	14	AD	ad	NN
cord-006702-ekf6mja9	1016	15	.	.	.
cord-006702-ekf6mja9	1017	1	Stratifying	stratify	VBG
cord-006702-ekf6mja9	1017	2	for	for	IN
cord-006702-ekf6mja9	1017	3	dependence	dependence	NN
cord-006702-ekf6mja9	1017	4	,	,	,
cord-006702-ekf6mja9	1017	5	patients	patient	NNS
cord-006702-ekf6mja9	1017	6	were	be	VBD
cord-006702-ekf6mja9	1017	7	randomly	randomly	RB
cord-006702-ekf6mja9	1017	8	assigned	assign	VBN
cord-006702-ekf6mja9	1017	9	to	to	IN
cord-006702-ekf6mja9	1017	10	prednisone	prednisone	NN
cord-006702-ekf6mja9	1017	11	at	at	IN
cord-006702-ekf6mja9	1017	12	0.2	0.2	CD
cord-006702-ekf6mja9	1017	13	-	-	HYPH
cord-006702-ekf6mja9	1017	14	0.3	0.3	CD
cord-006702-ekf6mja9	1017	15	mg	mg	NNP
cord-006702-ekf6mja9	1017	16	/	/	SYM
cord-006702-ekf6mja9	1017	17	kg	kg	NNP
cord-006702-ekf6mja9	1017	18	daily	daily	NN
cord-006702-ekf6mja9	1017	19	or	or	CC
cord-006702-ekf6mja9	1017	20	0.5	0.5	CD
cord-006702-ekf6mja9	1017	21	-	-	SYM
cord-006702-ekf6mja9	1017	22	0.7	0.7	CD
cord-006702-ekf6mja9	1017	23	mg	mg	NNP
cord-006702-ekf6mja9	1017	24	/	/	SYM
cord-006702-ekf6mja9	1017	25	kg	kg	NN
cord-006702-ekf6mja9	1017	26	AD	ad	NN
cord-006702-ekf6mja9	1017	27	for	for	IN
cord-006702-ekf6mja9	1017	28	12-months	12-months	CD
cord-006702-ekf6mja9	1017	29	.	.	.
cord-006702-ekf6mja9	1018	1	Relapses	relapse	NNS
cord-006702-ekf6mja9	1018	2	were	be	VBD
cord-006702-ekf6mja9	1018	3	treated	treat	VBN
cord-006702-ekf6mja9	1018	4	with	with	IN
cord-006702-ekf6mja9	1018	5	prednisone	prednisone	NNP
cord-006702-ekf6mja9	1018	6	,	,	,
cord-006702-ekf6mja9	1018	7	followed	follow	VBN
cord-006702-ekf6mja9	1018	8	by	by	IN
cord-006702-ekf6mja9	1018	9	return	return	NN
cord-006702-ekf6mja9	1018	10	to	to	IN
cord-006702-ekf6mja9	1018	11	intervention	intervention	NN
cord-006702-ekf6mja9	1018	12	.	.	.
cord-006702-ekf6mja9	1019	1	Outcomes	outcome	NNS
cord-006702-ekf6mja9	1019	2	,	,	,
cord-006702-ekf6mja9	1019	3	based	base	VBN
cord-006702-ekf6mja9	1019	4	on	on	IN
cord-006702-ekf6mja9	1019	5	intention	intention	NN
cord-006702-ekf6mja9	1019	6	-	-	HYPH
cord-006702-ekf6mja9	1019	7	to	to	IN
cord-006702-ekf6mja9	1019	8	-	-	HYPH
cord-006702-ekf6mja9	1019	9	treat	treat	NN
cord-006702-ekf6mja9	1019	10	,	,	,
cord-006702-ekf6mja9	1019	11	included	include	VBD
cord-006702-ekf6mja9	1019	12	number	number	NN
cord-006702-ekf6mja9	1019	13	of	of	IN
cord-006702-ekf6mja9	1019	14	relapses	relapse	NNS
cord-006702-ekf6mja9	1019	15	,	,	,
cord-006702-ekf6mja9	1019	16	proportions	proportion	NNS
cord-006702-ekf6mja9	1019	17	with	with	IN
cord-006702-ekf6mja9	1019	18	therapy	therapy	NN
cord-006702-ekf6mja9	1019	19	failure	failure	NN
cord-006702-ekf6mja9	1019	20	(	(	-LRB-
cord-006702-ekf6mja9	1019	21	≥2	≥2	NNP
cord-006702-ekf6mja9	1019	22	in	in	IN
cord-006702-ekf6mja9	1019	23	6-months	6-months	CD
cord-006702-ekf6mja9	1019	24	or	or	CC
cord-006702-ekf6mja9	1019	25	significant	significant	JJ
cord-006702-ekf6mja9	1019	26	steroid	steroid	NN
cord-006702-ekf6mja9	1019	27	toxicity	toxicity	NN
cord-006702-ekf6mja9	1019	28	)	)	-RRB-
cord-006702-ekf6mja9	1019	29	&	&	CC
cord-006702-ekf6mja9	1019	30	sustained	sustain	VBD
cord-006702-ekf6mja9	1019	31	remission	remission	NN
cord-006702-ekf6mja9	1019	32	,	,	,
cord-006702-ekf6mja9	1019	33	time	time	NN
cord-006702-ekf6mja9	1019	34	to	to	IN
cord-006702-ekf6mja9	1019	35	first	first	JJ
cord-006702-ekf6mja9	1019	36	relapse	relapse	VB
cord-006702-ekf6mja9	1019	37	&	&	CC
cord-006702-ekf6mja9	1019	38	frequent	frequent	JJ
cord-006702-ekf6mja9	1019	39	relapses	relapse	NNS
cord-006702-ekf6mja9	1019	40	,	,	,
cord-006702-ekf6mja9	1019	41	cumulative	cumulative	JJ
cord-006702-ekf6mja9	1019	42	prednisone	prednisone	NNP
cord-006702-ekf6mja9	1019	43	received	receive	VBD
cord-006702-ekf6mja9	1019	44	&	&	CC
cord-006702-ekf6mja9	1019	45	adverse	adverse	JJ
cord-006702-ekf6mja9	1019	46	events	event	NNS
cord-006702-ekf6mja9	1019	47	.	.	.
cord-006702-ekf6mja9	1020	1	Assuming	assume	VBG
cord-006702-ekf6mja9	1020	2	that	that	IN
cord-006702-ekf6mja9	1020	3	daily	daily	JJ
cord-006702-ekf6mja9	1020	4	therapy	therapy	NN
cord-006702-ekf6mja9	1020	5	will	will	MD
cord-006702-ekf6mja9	1020	6	reduce	reduce	VB
cord-006702-ekf6mja9	1020	7	relapses	relapse	NNS
cord-006702-ekf6mja9	1020	8	by	by	IN
cord-006702-ekf6mja9	1020	9	25	25	CD
cord-006702-ekf6mja9	1020	10	%	%	NN
cord-006702-ekf6mja9	1020	11	over	over	IN
cord-006702-ekf6mja9	1020	12	AD	ad	NN
cord-006702-ekf6mja9	1020	13	treatment	treatment	NN
cord-006702-ekf6mja9	1020	14	,	,	,
cord-006702-ekf6mja9	1020	15	62	62	CD
cord-006702-ekf6mja9	1020	16	patients	patient	NNS
cord-006702-ekf6mja9	1020	17	were	be	VBD
cord-006702-ekf6mja9	1020	18	required	require	VBN
cord-006702-ekf6mja9	1020	19	at	at	IN
cord-006702-ekf6mja9	1020	20	power	power	NN
cord-006702-ekf6mja9	1020	21	of	of	IN
cord-006702-ekf6mja9	1020	22	80	80	CD
cord-006702-ekf6mja9	1020	23	%	%	NN
cord-006702-ekf6mja9	1020	24	and	and	CC
cord-006702-ekf6mja9	1020	25	two	two	CD
cord-006702-ekf6mja9	1020	26	-	-	HYPH
cord-006702-ekf6mja9	1020	27	tailed	tailed	JJ
cord-006702-ekf6mja9	1020	28	α	α	NN
cord-006702-ekf6mja9	1020	29	of	of	IN
cord-006702-ekf6mja9	1020	30	0.05	0.05	CD
cord-006702-ekf6mja9	1020	31	,	,	,
cord-006702-ekf6mja9	1020	32	with	with	IN
cord-006702-ekf6mja9	1020	33	10	10	CD
cord-006702-ekf6mja9	1020	34	%	%	NN
cord-006702-ekf6mja9	1020	35	attrition	attrition	NN
cord-006702-ekf6mja9	1020	36	.	.	.
cord-006702-ekf6mja9	1021	1	Results	result	NNS
cord-006702-ekf6mja9	1021	2	:	:	:
cord-006702-ekf6mja9	1022	1	Of	of	IN
cord-006702-ekf6mja9	1022	2	62	62	CD
cord-006702-ekf6mja9	1022	3	patients	patient	NNS
cord-006702-ekf6mja9	1022	4	,	,	,
cord-006702-ekf6mja9	1022	5	one	one	PRP
cord-006702-ekf6mja9	1022	6	did	do	VBD
cord-006702-ekf6mja9	1022	7	not	not	RB
cord-006702-ekf6mja9	1022	8	return	return	VB
cord-006702-ekf6mja9	1022	9	following	follow	VBG
cord-006702-ekf6mja9	1022	10	randomization	randomization	NN
cord-006702-ekf6mja9	1022	11	&	&	CC
cord-006702-ekf6mja9	1022	12	was	be	VBD
cord-006702-ekf6mja9	1022	13	excluded	exclude	VBN
cord-006702-ekf6mja9	1022	14	from	from	IN
cord-006702-ekf6mja9	1022	15	the	the	DT
cord-006702-ekf6mja9	1022	16	analysis	analysis	NN
cord-006702-ekf6mja9	1022	17	(	(	-LRB-
cord-006702-ekf6mja9	1022	18	Fig	Fig	NNP
cord-006702-ekf6mja9	1022	19	.	.	.
cord-006702-ekf6mja9	1022	20	1	1	CD
cord-006702-ekf6mja9	1022	21	)	)	-RRB-
cord-006702-ekf6mja9	1022	22	.	.	.
cord-006702-ekf6mja9	1023	1	Baseline	baseline	JJ
cord-006702-ekf6mja9	1023	2	features	feature	NNS
cord-006702-ekf6mja9	1023	3	were	be	VBD
cord-006702-ekf6mja9	1023	4	similar	similar	JJ
cord-006702-ekf6mja9	1023	5	in	in	IN
cord-006702-ekf6mja9	1023	6	the	the	DT
cord-006702-ekf6mja9	1023	7	two	two	CD
cord-006702-ekf6mja9	1023	8	groups	group	NNS
cord-006702-ekf6mja9	1023	9	.	.	.
cord-006702-ekf6mja9	1024	1	Patients	patient	NNS
cord-006702-ekf6mja9	1024	2	receiving	receive	VBG
cord-006702-ekf6mja9	1024	3	daily	daily	JJ
cord-006702-ekf6mja9	1024	4	prednisone	prednisone	NNP
cord-006702-ekf6mja9	1024	5	showed	show	VBD
cord-006702-ekf6mja9	1024	6	significantly	significantly	RB
cord-006702-ekf6mja9	1024	7	less	less	RBR
cord-006702-ekf6mja9	1024	8	relapses	relapse	NNS
cord-006702-ekf6mja9	1024	9	than	than	IN
cord-006702-ekf6mja9	1024	10	those	those	DT
cord-006702-ekf6mja9	1024	11	on	on	IN
cord-006702-ekf6mja9	1024	12	AD	ad	NN
cord-006702-ekf6mja9	1024	13	therapy	therapy	NN
cord-006702-ekf6mja9	1024	14	(	(	-LRB-
cord-006702-ekf6mja9	1024	15	0.5±0.7	0.5±0.7	FW
cord-006702-ekf6mja9	1024	16	vs.	vs.	FW
cord-006702-ekf6mja9	1024	17	1.4±1.0	1.4±1.0	CD
cord-006702-ekf6mja9	1024	18	relapses	relapse	NNS
cord-006702-ekf6mja9	1024	19	;	;	:
cord-006702-ekf6mja9	1024	20	mean	mean	VB
cord-006702-ekf6mja9	1024	21	difference	difference	NN
cord-006702-ekf6mja9	1024	22	0.8	0.8	CD
cord-006702-ekf6mja9	1024	23	;	;	:
cord-006702-ekf6mja9	1024	24	95%CI	95%ci	CD
cord-006702-ekf6mja9	1024	25	0.3	0.3	CD
cord-006702-ekf6mja9	1024	26	-	-	SYM
cord-006702-ekf6mja9	1024	27	1.3	1.3	CD
cord-006702-ekf6mja9	1024	28	;	;	:
cord-006702-ekf6mja9	1024	29	P=0.0005	P=0.0005	NNP
cord-006702-ekf6mja9	1024	30	)	)	-RRB-
cord-006702-ekf6mja9	1024	31	.	.	.
cord-006702-ekf6mja9	1025	1	Daily	daily	JJ
cord-006702-ekf6mja9	1025	2	therapy	therapy	NN
cord-006702-ekf6mja9	1025	3	was	be	VBD
cord-006702-ekf6mja9	1025	4	associated	associate	VBN
cord-006702-ekf6mja9	1025	5	with	with	IN
cord-006702-ekf6mja9	1025	6	higher	high	JJR
cord-006702-ekf6mja9	1025	7	proportion	proportion	NN
cord-006702-ekf6mja9	1025	8	in	in	IN
cord-006702-ekf6mja9	1025	9	sustained	sustained	JJ
cord-006702-ekf6mja9	1025	10	remission	remission	NN
cord-006702-ekf6mja9	1025	11	(	(	-LRB-
cord-006702-ekf6mja9	1025	12	60	60	CD
cord-006702-ekf6mja9	1025	13	%	%	NN
cord-006702-ekf6mja9	1025	14	vs.	vs.	IN
cord-006702-ekf6mja9	1025	15	29	29	CD
cord-006702-ekf6mja9	1025	16	%	%	NN
cord-006702-ekf6mja9	1025	17	;	;	:
cord-006702-ekf6mja9	1025	18	P=0.015	P=0.015	NNP
cord-006702-ekf6mja9	1025	19	)	)	-RRB-
cord-006702-ekf6mja9	1025	20	,	,	,
cord-006702-ekf6mja9	1025	21	lower	low	JJR
cord-006702-ekf6mja9	1025	22	treatment	treatment	NN
cord-006702-ekf6mja9	1025	23	failure	failure	NN
cord-006702-ekf6mja9	1025	24	(	(	-LRB-
cord-006702-ekf6mja9	1025	25	7	7	CD
cord-006702-ekf6mja9	1025	26	%	%	NN
cord-006702-ekf6mja9	1025	27	vs.	vs.	IN
cord-006702-ekf6mja9	1025	28	55	55	CD
cord-006702-ekf6mja9	1025	29	%	%	NN
cord-006702-ekf6mja9	1025	30	;	;	,
cord-006702-ekf6mja9	1025	31	P<0.0001	p<0.0001	JJ
cord-006702-ekf6mja9	1025	32	)	)	-RRB-
cord-006702-ekf6mja9	1025	33	,	,	,
cord-006702-ekf6mja9	1025	34	delayed	delay	VBN
cord-006702-ekf6mja9	1025	35	time	time	NN
cord-006702-ekf6mja9	1025	36	to	to	IN
cord-006702-ekf6mja9	1025	37	first	first	JJ
cord-006702-ekf6mja9	1025	38	relapse	relapse	VB
cord-006702-ekf6mja9	1025	39	(	(	-LRB-
cord-006702-ekf6mja9	1025	40	log	log	NN
cord-006702-ekf6mja9	1025	41	rank	rank	NN
cord-006702-ekf6mja9	1025	42	P=0.0028	P=0.0028	NNP
cord-006702-ekf6mja9	1025	43	)	)	-RRB-
cord-006702-ekf6mja9	1025	44	and	and	CC
cord-006702-ekf6mja9	1025	45	to	to	IN
cord-006702-ekf6mja9	1025	46	treatment	treatment	NN
cord-006702-ekf6mja9	1025	47	failure	failure	NN
cord-006702-ekf6mja9	1025	48	(	(	-LRB-
cord-006702-ekf6mja9	1025	49	P<0.0001	p<0.0001	NN
cord-006702-ekf6mja9	1025	50	)	)	-RRB-
cord-006702-ekf6mja9	1026	1	(	(	-LRB-
cord-006702-ekf6mja9	1026	2	Fig	Fig	NNP
cord-006702-ekf6mja9	1026	3	.	.	NNP
cord-006702-ekf6mja9	1026	4	2	2	CD
cord-006702-ekf6mja9	1026	5	)	)	-RRB-
cord-006702-ekf6mja9	1026	6	and	and	CC
cord-006702-ekf6mja9	1027	1	lower	lower	VB
cord-006702-ekf6mja9	1027	2	prednisone	prednisone	NNP
cord-006702-ekf6mja9	1027	3	use	use	NN
cord-006702-ekf6mja9	1027	4	(	(	-LRB-
cord-006702-ekf6mja9	1027	5	0.3±0.7	0.3±0.7	NNP
cord-006702-ekf6mja9	1027	6	vs.	vs.	FW
cord-006702-ekf6mja9	1027	7	0.4±0.2	0.4±0.2	NNP
cord-006702-ekf6mja9	1027	8	mg	mg	NNP
cord-006702-ekf6mja9	1027	9	/	/	SYM
cord-006702-ekf6mja9	1027	10	kg	kg	NNP
cord-006702-ekf6mja9	1027	11	;	;	:
cord-006702-ekf6mja9	1027	12	P=0.0033	P=0.0033	NNP
cord-006702-ekf6mja9	1027	13	)	)	-RRB-
cord-006702-ekf6mja9	1027	14	.	.	.
cord-006702-ekf6mja9	1028	1	Adverse	adverse	JJ
cord-006702-ekf6mja9	1028	2	events	event	NNS
cord-006702-ekf6mja9	1028	3	were	be	VBD
cord-006702-ekf6mja9	1028	4	similar	similar	JJ
cord-006702-ekf6mja9	1028	5	.	.	.
cord-006702-ekf6mja9	1029	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1029	2	:	:	:
cord-006702-ekf6mja9	1030	1	In	in	IN
cord-006702-ekf6mja9	1030	2	patients	patient	NNS
cord-006702-ekf6mja9	1030	3	with	with	IN
cord-006702-ekf6mja9	1030	4	FRNS	FRNS	NNP
cord-006702-ekf6mja9	1030	5	,	,	,
cord-006702-ekf6mja9	1030	6	daily	daily	JJ
cord-006702-ekf6mja9	1030	7	administration	administration	NN
cord-006702-ekf6mja9	1030	8	of	of	IN
cord-006702-ekf6mja9	1030	9	low	low	JJ
cord-006702-ekf6mja9	1030	10	-	-	HYPH
cord-006702-ekf6mja9	1030	11	dose	dose	NN
cord-006702-ekf6mja9	1030	12	prednisone	prednisone	NN
cord-006702-ekf6mja9	1030	13	was	be	VBD
cord-006702-ekf6mja9	1030	14	more	more	RBR
cord-006702-ekf6mja9	1030	15	effective	effective	JJ
cord-006702-ekf6mja9	1030	16	than	than	IN
cord-006702-ekf6mja9	1030	17	standard	standard	JJ
cord-006702-ekf6mja9	1030	18	-	-	HYPH
cord-006702-ekf6mja9	1030	19	dose	dose	NN
cord-006702-ekf6mja9	1030	20	alternate	alternate	JJ
cord-006702-ekf6mja9	1030	21	day	day	NN
cord-006702-ekf6mja9	1030	22	therapy	therapy	NN
cord-006702-ekf6mja9	1030	23	in	in	IN
cord-006702-ekf6mja9	1030	24	sustaining	sustain	VBG
cord-006702-ekf6mja9	1030	25	remission	remission	NN
cord-006702-ekf6mja9	1030	26	and	and	CC
cord-006702-ekf6mja9	1030	27	enabling	enable	VBG
cord-006702-ekf6mja9	1030	28	steroid	steroid	NN
cord-006702-ekf6mja9	1030	29	sparing	sparing	NN
cord-006702-ekf6mja9	1030	30	.	.	.
cord-006702-ekf6mja9	1030	31	 	 	_SP
cord-006702-ekf6mja9	1031	1	Levamisole	levamisole	NN
cord-006702-ekf6mja9	1031	2	increases	increase	VBZ
cord-006702-ekf6mja9	1031	3	the	the	DT
cord-006702-ekf6mja9	1031	4	time	time	NN
cord-006702-ekf6mja9	1031	5	to	to	TO
cord-006702-ekf6mja9	1031	6	relapse	relapse	VB
cord-006702-ekf6mja9	1031	7	in	in	IN
cord-006702-ekf6mja9	1031	8	children	child	NNS
cord-006702-ekf6mja9	1031	9	with	with	IN
cord-006702-ekf6mja9	1031	10	steroid	steroid	NN
cord-006702-ekf6mja9	1031	11	-	-	HYPH
cord-006702-ekf6mja9	1031	12	sensitive	sensitive	JJ
cord-006702-ekf6mja9	1031	13	idiopathic	idiopathic	JJ
cord-006702-ekf6mja9	1031	14	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	1031	15	syndrome	syndrome	NN
cord-006702-ekf6mja9	1031	16	:	:	:
cord-006702-ekf6mja9	1031	17	results	result	NNS
cord-006702-ekf6mja9	1031	18	of	of	IN
cord-006702-ekf6mja9	1031	19	a	a	DT
cord-006702-ekf6mja9	1031	20	multi	multi	JJ
cord-006702-ekf6mja9	1031	21	-	-	JJ
cord-006702-ekf6mja9	1031	22	center	center	JJ
cord-006702-ekf6mja9	1031	23	,	,	,
cord-006702-ekf6mja9	1031	24	double	double	JJ
cord-006702-ekf6mja9	1031	25	-	-	HYPH
cord-006702-ekf6mja9	1031	26	blind	blind	JJ
cord-006702-ekf6mja9	1031	27	,	,	,
cord-006702-ekf6mja9	1031	28	placebo	placebo	NN
cord-006702-ekf6mja9	1031	29	-	-	HYPH
cord-006702-ekf6mja9	1031	30	controlled	control	VBN
cord-006702-ekf6mja9	1031	31	,	,	,
cord-006702-ekf6mja9	1031	32	randomized	randomized	JJ
cord-006702-ekf6mja9	1031	33	clinical	clinical	JJ
cord-006702-ekf6mja9	1031	34	trial	trial	NN
cord-006702-ekf6mja9	1031	35	M.	M.	NNP
cord-006702-ekf6mja9	1031	36	Gruppen	Gruppen	NNP
cord-006702-ekf6mja9	1031	37	(	(	-LRB-
cord-006702-ekf6mja9	1031	38	1	1	CD
cord-006702-ekf6mja9	1031	39	)	)	-RRB-
cord-006702-ekf6mja9	1031	40	,	,	,
cord-006702-ekf6mja9	1031	41	J.C.	J.C.	NNP
cord-006702-ekf6mja9	1031	42	Davin	Davin	NNP
cord-006702-ekf6mja9	1031	43	(	(	-LRB-
cord-006702-ekf6mja9	1031	44	2	2	CD
cord-006702-ekf6mja9	1031	45	)	)	-RRB-
cord-006702-ekf6mja9	1031	46	,	,	,
cord-006702-ekf6mja9	1031	47	A.	a.	NN
cord-006702-ekf6mja9	1031	48	Bouts	bout	NNS
cord-006702-ekf6mja9	1031	49	(	(	-LRB-
cord-006702-ekf6mja9	1031	50	2	2	CD
cord-006702-ekf6mja9	1031	51	)	)	-RRB-
cord-006702-ekf6mja9	1032	1	(	(	-LRB-
cord-006702-ekf6mja9	1032	2	1	1	CD
cord-006702-ekf6mja9	1032	3	)	)	-RRB-
cord-006702-ekf6mja9	1032	4	Pediatrician	Pediatrician	NNP
cord-006702-ekf6mja9	1032	5	,	,	,
cord-006702-ekf6mja9	1032	6	AMC	AMC	NNP
cord-006702-ekf6mja9	1032	7	,	,	,
cord-006702-ekf6mja9	1032	8	Amsterdam	Amsterdam	NNP
cord-006702-ekf6mja9	1032	9	,	,	,
cord-006702-ekf6mja9	1032	10	Netherlands	Netherlands	NNP
cord-006702-ekf6mja9	1032	11	;	;	:
cord-006702-ekf6mja9	1032	12	(	(	-LRB-
cord-006702-ekf6mja9	1032	13	2	2	LS
cord-006702-ekf6mja9	1032	14	)	)	-RRB-
cord-006702-ekf6mja9	1032	15	Pediatric	pediatric	JJ
cord-006702-ekf6mja9	1032	16	nephrologist	nephrologist	NN
cord-006702-ekf6mja9	1032	17	,	,	,
cord-006702-ekf6mja9	1032	18	ACM	ACM	NNP
cord-006702-ekf6mja9	1032	19	,	,	,
cord-006702-ekf6mja9	1032	20	Amsterdam	Amsterdam	NNP
cord-006702-ekf6mja9	1032	21	,	,	,
cord-006702-ekf6mja9	1033	1	Netherlands	Netherlands	NNP
cord-006702-ekf6mja9	1033	2	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1033	3	:	:	:
cord-006702-ekf6mja9	1034	1	Levamisole	levamisole	NN
cord-006702-ekf6mja9	1034	2	has	have	VBZ
cord-006702-ekf6mja9	1034	3	been	be	VBN
cord-006702-ekf6mja9	1034	4	considered	consider	VBN
cord-006702-ekf6mja9	1034	5	the	the	DT
cord-006702-ekf6mja9	1034	6	least	least	JJS
cord-006702-ekf6mja9	1034	7	toxic	toxic	JJ
cord-006702-ekf6mja9	1034	8	and	and	CC
cord-006702-ekf6mja9	1034	9	expensive	expensive	JJ
cord-006702-ekf6mja9	1034	10	drug	drug	NN
cord-006702-ekf6mja9	1034	11	for	for	IN
cord-006702-ekf6mja9	1034	12	preventing	prevent	VBG
cord-006702-ekf6mja9	1034	13	relapses	relapse	NNS
cord-006702-ekf6mja9	1034	14	of	of	IN
cord-006702-ekf6mja9	1034	15	steroid	steroid	NN
cord-006702-ekf6mja9	1034	16	sensitive	sensitive	JJ
cord-006702-ekf6mja9	1034	17	idiopathic	idiopathic	JJ
cord-006702-ekf6mja9	1034	18	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	1034	19	syndrome	syndrome	NN
cord-006702-ekf6mja9	1034	20	(	(	-LRB-
cord-006702-ekf6mja9	1034	21	SSINS	SSINS	NNP
cord-006702-ekf6mja9	1034	22	)	)	-RRB-
cord-006702-ekf6mja9	1034	23	.	.	.
cord-006702-ekf6mja9	1035	1	However	however	RB
cord-006702-ekf6mja9	1035	2	,	,	,
cord-006702-ekf6mja9	1035	3	evidence	evidence	NN
cord-006702-ekf6mja9	1035	4	is	be	VBZ
cord-006702-ekf6mja9	1035	5	limited	limit	VBN
cord-006702-ekf6mja9	1035	6	,	,	,
cord-006702-ekf6mja9	1035	7	as	as	IN
cord-006702-ekf6mja9	1035	8	previous	previous	JJ
cord-006702-ekf6mja9	1035	9	randomized	randomized	JJ
cord-006702-ekf6mja9	1035	10	clinical	clinical	JJ
cord-006702-ekf6mja9	1035	11	trials	trial	NNS
cord-006702-ekf6mja9	1035	12	(	(	-LRB-
cord-006702-ekf6mja9	1035	13	RCTs	RCTs	NNP
cord-006702-ekf6mja9	1035	14	)	)	-RRB-
cord-006702-ekf6mja9	1035	15	were	be	VBD
cord-006702-ekf6mja9	1035	16	found	find	VBN
cord-006702-ekf6mja9	1035	17	to	to	TO
cord-006702-ekf6mja9	1035	18	have	have	VB
cord-006702-ekf6mja9	1035	19	methodological	methodological	JJ
cord-006702-ekf6mja9	1035	20	limitations	limitation	NNS
cord-006702-ekf6mja9	1035	21	.	.	.
cord-006702-ekf6mja9	1036	1	This	this	DT
cord-006702-ekf6mja9	1036	2	is	be	VBZ
cord-006702-ekf6mja9	1036	3	why	why	WRB
cord-006702-ekf6mja9	1036	4	we	-PRON-	PRP
cord-006702-ekf6mja9	1036	5	conducted	conduct	VBD
cord-006702-ekf6mja9	1036	6	an	an	DT
cord-006702-ekf6mja9	1036	7	appropriate	appropriate	JJ
cord-006702-ekf6mja9	1036	8	RCT	RCT	NNP
cord-006702-ekf6mja9	1036	9	to	to	TO
cord-006702-ekf6mja9	1036	10	reassess	reassess	VB
cord-006702-ekf6mja9	1036	11	its	-PRON-	PRP$
cord-006702-ekf6mja9	1036	12	usefulness	usefulness	NN
cord-006702-ekf6mja9	1036	13	in	in	IN
cord-006702-ekf6mja9	1036	14	prevention	prevention	NN
cord-006702-ekf6mja9	1036	15	of	of	IN
cord-006702-ekf6mja9	1036	16	SSINS	SSINS	NNP
cord-006702-ekf6mja9	1036	17	relapses	relapse	NNS
cord-006702-ekf6mja9	1036	18	in	in	IN
cord-006702-ekf6mja9	1036	19	children	child	NNS
cord-006702-ekf6mja9	1036	20	.	.	.
cord-006702-ekf6mja9	1037	1	Methods	method	NNS
cord-006702-ekf6mja9	1037	2	:	:	:
cord-006702-ekf6mja9	1037	3	The	the	DT
cord-006702-ekf6mja9	1037	4	study	study	NN
cord-006702-ekf6mja9	1037	5	was	be	VBD
cord-006702-ekf6mja9	1037	6	conducted	conduct	VBN
cord-006702-ekf6mja9	1037	7	in	in	IN
cord-006702-ekf6mja9	1037	8	an	an	DT
cord-006702-ekf6mja9	1037	9	international	international	JJ
cord-006702-ekf6mja9	1037	10	multi	multi	JJ
cord-006702-ekf6mja9	1037	11	-	-	JJ
cord-006702-ekf6mja9	1037	12	center	center	JJ
cord-006702-ekf6mja9	1037	13	,	,	,
cord-006702-ekf6mja9	1037	14	placebo	placebo	NN
cord-006702-ekf6mja9	1037	15	-	-	HYPH
cord-006702-ekf6mja9	1037	16	controlled	control	VBN
cord-006702-ekf6mja9	1037	17	,	,	,
cord-006702-ekf6mja9	1037	18	double	double	JJ
cord-006702-ekf6mja9	1037	19	-	-	HYPH
cord-006702-ekf6mja9	1037	20	blind	blind	JJ
cord-006702-ekf6mja9	1037	21	RCT	RCT	NNP
cord-006702-ekf6mja9	1037	22	for	for	IN
cord-006702-ekf6mja9	1037	23	one	one	CD
cord-006702-ekf6mja9	1037	24	year	year	NN
cord-006702-ekf6mja9	1037	25	,	,	,
cord-006702-ekf6mja9	1037	26	in	in	IN
cord-006702-ekf6mja9	1037	27	order	order	NN
cord-006702-ekf6mja9	1037	28	to	to	TO
cord-006702-ekf6mja9	1037	29	evaluate	evaluate	VB
cord-006702-ekf6mja9	1037	30	efficacy	efficacy	NN
cord-006702-ekf6mja9	1037	31	and	and	CC
cord-006702-ekf6mja9	1037	32	safety	safety	NN
cord-006702-ekf6mja9	1037	33	of	of	IN
cord-006702-ekf6mja9	1037	34	levamisole	levamisole	NN
cord-006702-ekf6mja9	1037	35	in	in	IN
cord-006702-ekf6mja9	1037	36	children	child	NNS
cord-006702-ekf6mja9	1037	37	with	with	IN
cord-006702-ekf6mja9	1037	38	SSINS	SSINS	NNP
cord-006702-ekf6mja9	1037	39	and	and	CC
cord-006702-ekf6mja9	1037	40	frequent	frequent	JJ
cord-006702-ekf6mja9	1037	41	relapses	relapse	NNS
cord-006702-ekf6mja9	1037	42	.	.	.
cord-006702-ekf6mja9	1038	1	Results	result	NNS
cord-006702-ekf6mja9	1038	2	:	:	:
cord-006702-ekf6mja9	1039	1	The	the	DT
cord-006702-ekf6mja9	1039	2	intention	intention	NN
cord-006702-ekf6mja9	1039	3	to	to	TO
cord-006702-ekf6mja9	1039	4	treat	treat	VB
cord-006702-ekf6mja9	1039	5	population	population	NN
cord-006702-ekf6mja9	1039	6	(	(	-LRB-
cord-006702-ekf6mja9	1039	7	ITT	ITT	NNP
cord-006702-ekf6mja9	1039	8	)	)	-RRB-
cord-006702-ekf6mja9	1039	9	consisted	consist	VBD
cord-006702-ekf6mja9	1039	10	of	of	IN
cord-006702-ekf6mja9	1039	11	99	99	CD
cord-006702-ekf6mja9	1039	12	patients	patient	NNS
cord-006702-ekf6mja9	1039	13	from	from	IN
cord-006702-ekf6mja9	1039	14	6	6	CD
cord-006702-ekf6mja9	1039	15	countries	country	NNS
cord-006702-ekf6mja9	1039	16	.	.	.
cord-006702-ekf6mja9	1040	1	Time	time	NN
cord-006702-ekf6mja9	1040	2	to	to	TO
cord-006702-ekf6mja9	1040	3	relapse	relapse	VB
cord-006702-ekf6mja9	1040	4	(	(	-LRB-
cord-006702-ekf6mja9	1040	5	primary	primary	JJ
cord-006702-ekf6mja9	1040	6	endpoint	endpoint	NN
cord-006702-ekf6mja9	1040	7	)	)	-RRB-
cord-006702-ekf6mja9	1040	8	was	be	VBD
cord-006702-ekf6mja9	1040	9	significantly	significantly	RB
cord-006702-ekf6mja9	1040	10	increased	increase	VBN
cord-006702-ekf6mja9	1040	11	in	in	IN
cord-006702-ekf6mja9	1040	12	the	the	DT
cord-006702-ekf6mja9	1040	13	intervention	intervention	NN
cord-006702-ekf6mja9	1040	14	group	group	NN
cord-006702-ekf6mja9	1040	15	compared	compare	VBN
cord-006702-ekf6mja9	1040	16	to	to	IN
cord-006702-ekf6mja9	1040	17	placebo	placebo	NN
cord-006702-ekf6mja9	1040	18	(	(	-LRB-
cord-006702-ekf6mja9	1040	19	p	p	NN
cord-006702-ekf6mja9	1040	20	-	-	HYPH
cord-006702-ekf6mja9	1040	21	value	value	NN
cord-006702-ekf6mja9	1040	22	0.22	0.22	CD
cord-006702-ekf6mja9	1040	23	[	[	-LRB-
cord-006702-ekf6mja9	1040	24	95	95	CD
cord-006702-ekf6mja9	1040	25	%	%	NN
cord-006702-ekf6mja9	1040	26	CI	CI	NNP
cord-006702-ekf6mja9	1040	27	0.11	0.11	CD
cord-006702-ekf6mja9	1040	28	-	-	HYPH
cord-006702-ekf6mja9	1040	29	0.43	0.43	CD
cord-006702-ekf6mja9	1040	30	]	]	-RRB-
cord-006702-ekf6mja9	1040	31	,	,	,
cord-006702-ekf6mja9	1040	32	p	p	NN
cord-006702-ekf6mja9	1040	33	-	-	HYPH
cord-006702-ekf6mja9	1040	34	value	value	NN
cord-006702-ekf6mja9	1040	35	0.001	0.001	CD
cord-006702-ekf6mja9	1040	36	after	after	IN
cord-006702-ekf6mja9	1040	37	100	100	CD
cord-006702-ekf6mja9	1040	38	days	day	NNS
cord-006702-ekf6mja9	1040	39	post	post	NN
cord-006702-ekf6mja9	1040	40	-	-	JJ
cord-006702-ekf6mja9	1040	41	randomization	randomization	JJ
cord-006702-ekf6mja9	1040	42	)	)	-RRB-
cord-006702-ekf6mja9	1040	43	.	.	.
cord-006702-ekf6mja9	1041	1	After	after	IN
cord-006702-ekf6mja9	1041	2	12	12	CD
cord-006702-ekf6mja9	1041	3	months	month	NNS
cord-006702-ekf6mja9	1041	4	of	of	IN
cord-006702-ekf6mja9	1041	5	treatment	treatment	NN
cord-006702-ekf6mja9	1041	6	,	,	,
cord-006702-ekf6mja9	1041	7	remission	remission	NN
cord-006702-ekf6mja9	1041	8	persistence	persistence	NN
cord-006702-ekf6mja9	1041	9	was	be	VBD
cord-006702-ekf6mja9	1041	10	more	more	RBR
cord-006702-ekf6mja9	1041	11	frequent	frequent	JJ
cord-006702-ekf6mja9	1041	12	in	in	IN
cord-006702-ekf6mja9	1041	13	levamisole	levamisole	NN
cord-006702-ekf6mja9	1041	14	than	than	IN
cord-006702-ekf6mja9	1041	15	in	in	IN
cord-006702-ekf6mja9	1041	16	the	the	DT
cord-006702-ekf6mja9	1041	17	placebo	placebo	NN
cord-006702-ekf6mja9	1041	18	group	group	NN
cord-006702-ekf6mja9	1041	19	(	(	-LRB-
cord-006702-ekf6mja9	1041	20	26	26	CD
cord-006702-ekf6mja9	1041	21	%	%	NN
cord-006702-ekf6mja9	1041	22	vs	vs	IN
cord-006702-ekf6mja9	1041	23	6	6	CD
cord-006702-ekf6mja9	1041	24	%	%	NN
cord-006702-ekf6mja9	1041	25	:	:	:
cord-006702-ekf6mja9	1041	26	p	p	NN
cord-006702-ekf6mja9	1041	27	=	=	SYM
cord-006702-ekf6mja9	1041	28	0.012	0.012	CD
cord-006702-ekf6mja9	1041	29	)	)	-RRB-
cord-006702-ekf6mja9	1041	30	.	.	.
cord-006702-ekf6mja9	1042	1	The	the	DT
cord-006702-ekf6mja9	1042	2	most	most	RBS
cord-006702-ekf6mja9	1042	3	frequent	frequent	JJ
cord-006702-ekf6mja9	1042	4	serious	serious	JJ
cord-006702-ekf6mja9	1042	5	adverse	adverse	JJ
cord-006702-ekf6mja9	1042	6	event	event	NN
cord-006702-ekf6mja9	1042	7	(	(	-LRB-
cord-006702-ekf6mja9	1042	8	SAE	SAE	NNP
cord-006702-ekf6mja9	1042	9	)	)	-RRB-
cord-006702-ekf6mja9	1042	10	(	(	-LRB-
cord-006702-ekf6mja9	1042	11	4/50	4/50	LS
cord-006702-ekf6mja9	1042	12	)	)	-RRB-
cord-006702-ekf6mja9	1042	13	possibly	possibly	RB
cord-006702-ekf6mja9	1042	14	related	relate	VBN
cord-006702-ekf6mja9	1042	15	to	to	IN
cord-006702-ekf6mja9	1042	16	levamisole	levamisole	NN
cord-006702-ekf6mja9	1042	17	was	be	VBD
cord-006702-ekf6mja9	1042	18	asymptomatic	asymptomatic	JJ
cord-006702-ekf6mja9	1042	19	moderate	moderate	JJ
cord-006702-ekf6mja9	1042	20	neutropenia	neutropenia	NN
cord-006702-ekf6mja9	1043	1	(	(	-LRB-
cord-006702-ekf6mja9	1043	2	500	500	CD
cord-006702-ekf6mja9	1043	3	-	-	SYM
cord-006702-ekf6mja9	1043	4	1000	1000	CD
cord-006702-ekf6mja9	1043	5	cells/	cells/	CD
cord-006702-ekf6mja9	1043	6	μL	μL	NNP
cord-006702-ekf6mja9	1043	7	)	)	-RRB-
cord-006702-ekf6mja9	1043	8	,	,	,
cord-006702-ekf6mja9	1043	9	reversible	reversible	JJ
cord-006702-ekf6mja9	1043	10	spontaneously	spontaneously	RB
cord-006702-ekf6mja9	1043	11	or	or	CC
cord-006702-ekf6mja9	1043	12	after	after	IN
cord-006702-ekf6mja9	1043	13	treatment	treatment	NN
cord-006702-ekf6mja9	1043	14	interruption	interruption	NN
cord-006702-ekf6mja9	1043	15	.	.	.
cord-006702-ekf6mja9	1044	1	Rare	rare	JJ
cord-006702-ekf6mja9	1044	2	,	,	,
cord-006702-ekf6mja9	1044	3	severe	severe	JJ
cord-006702-ekf6mja9	1044	4	side	side	NN
cord-006702-ekf6mja9	1044	5	effects	effect	NNS
cord-006702-ekf6mja9	1044	6	of	of	IN
cord-006702-ekf6mja9	1044	7	levamisole	levamisole	NN
cord-006702-ekf6mja9	1044	8	reported	report	VBN
cord-006702-ekf6mja9	1044	9	in	in	IN
cord-006702-ekf6mja9	1044	10	treatment	treatment	NN
cord-006702-ekf6mja9	1044	11	of	of	IN
cord-006702-ekf6mja9	1044	12	SSINS	SSINS	NNP
cord-006702-ekf6mja9	1044	13	included	include	VBD
cord-006702-ekf6mja9	1044	14	hepatitis	hepatitis	NN
cord-006702-ekf6mja9	1044	15	,	,	,
cord-006702-ekf6mja9	1044	16	convulsions	convulsion	NNS
cord-006702-ekf6mja9	1044	17	or	or	CC
cord-006702-ekf6mja9	1044	18	antineutrophil	antineutrophil	VBP
cord-006702-ekf6mja9	1044	19	cytoplasmic	cytoplasmic	JJ
cord-006702-ekf6mja9	1044	20	antibody	antibody	NN
cord-006702-ekf6mja9	1044	21	(	(	-LRB-
cord-006702-ekf6mja9	1044	22	ANCA	ANCA	NNP
cord-006702-ekf6mja9	1044	23	)	)	-RRB-
cord-006702-ekf6mja9	1044	24	vasculitis	vasculitis	NN
cord-006702-ekf6mja9	1044	25	were	be	VBD
cord-006702-ekf6mja9	1044	26	not	not	RB
cord-006702-ekf6mja9	1044	27	observed	observe	VBN
cord-006702-ekf6mja9	1044	28	in	in	IN
cord-006702-ekf6mja9	1044	29	this	this	DT
cord-006702-ekf6mja9	1044	30	study	study	NN
cord-006702-ekf6mja9	1044	31	.	.	.
cord-006702-ekf6mja9	1045	1	However	however	RB
cord-006702-ekf6mja9	1045	2	,	,	,
cord-006702-ekf6mja9	1045	3	ANCA	ANCA	NNP
cord-006702-ekf6mja9	1045	4	-	-	HYPH
cord-006702-ekf6mja9	1045	5	related	relate	VBN
cord-006702-ekf6mja9	1045	6	arthritis	arthritis	NN
cord-006702-ekf6mja9	1045	7	was	be	VBD
cord-006702-ekf6mja9	1045	8	reversible	reversible	JJ
cord-006702-ekf6mja9	1045	9	with	with	IN
cord-006702-ekf6mja9	1045	10	levamisole	levamisole	JJ
cord-006702-ekf6mja9	1045	11	interruption	interruption	NN
cord-006702-ekf6mja9	1045	12	,	,	,
cord-006702-ekf6mja9	1045	13	and	and	CC
cord-006702-ekf6mja9	1045	14	reported	report	VBD
cord-006702-ekf6mja9	1045	15	in	in	IN
cord-006702-ekf6mja9	1045	16	one	one	CD
cord-006702-ekf6mja9	1045	17	patient	patient	NN
cord-006702-ekf6mja9	1045	18	.	.	.
cord-006702-ekf6mja9	1046	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1046	2	:	:	:
cord-006702-ekf6mja9	1047	1	In	in	IN
cord-006702-ekf6mja9	1047	2	children	child	NNS
cord-006702-ekf6mja9	1047	3	with	with	IN
cord-006702-ekf6mja9	1047	4	SSINS	SSINS	NNP
cord-006702-ekf6mja9	1047	5	and	and	CC
cord-006702-ekf6mja9	1047	6	frequent	frequent	JJ
cord-006702-ekf6mja9	1047	7	relapses	relapse	NNS
cord-006702-ekf6mja9	1047	8	,	,	,
cord-006702-ekf6mja9	1047	9	levamisole	levamisole	NN
cord-006702-ekf6mja9	1047	10	prolongs	prolong	VBZ
cord-006702-ekf6mja9	1047	11	time	time	NN
cord-006702-ekf6mja9	1047	12	to	to	TO
cord-006702-ekf6mja9	1047	13	relapse	relapse	VB
cord-006702-ekf6mja9	1047	14	and	and	CC
cord-006702-ekf6mja9	1047	15	also	also	RB
cord-006702-ekf6mja9	1047	16	prevents	prevent	VBZ
cord-006702-ekf6mja9	1047	17	recurrence	recurrence	NN
cord-006702-ekf6mja9	1047	18	for	for	IN
cord-006702-ekf6mja9	1047	19	one	one	CD
cord-006702-ekf6mja9	1047	20	-	-	HYPH
cord-006702-ekf6mja9	1047	21	year	year	NN
cord-006702-ekf6mja9	1047	22	of	of	IN
cord-006702-ekf6mja9	1047	23	treatment	treatment	NN
cord-006702-ekf6mja9	1047	24	in	in	IN
cord-006702-ekf6mja9	1047	25	20	20	CD
cord-006702-ekf6mja9	1047	26	%	%	NN
cord-006702-ekf6mja9	1047	27	of	of	IN
cord-006702-ekf6mja9	1047	28	patients	patient	NNS
cord-006702-ekf6mja9	1047	29	.	.	.
cord-006702-ekf6mja9	1048	1	Regular	regular	JJ
cord-006702-ekf6mja9	1048	2	blood	blood	NN
cord-006702-ekf6mja9	1048	3	controls	control	NNS
cord-006702-ekf6mja9	1048	4	are	be	VBP
cord-006702-ekf6mja9	1048	5	necessary	necessary	JJ
cord-006702-ekf6mja9	1048	6	for	for	IN
cord-006702-ekf6mja9	1048	7	safety	safety	NN
cord-006702-ekf6mja9	1048	8	issues	issue	NNS
cord-006702-ekf6mja9	1048	9	.	.	.
cord-006702-ekf6mja9	1048	10	 	 	_SP
cord-006702-ekf6mja9	1049	1	Defective	defective	JJ
cord-006702-ekf6mja9	1049	2	complement	complement	NN
cord-006702-ekf6mja9	1049	3	inhibitor	inhibitor	NN
cord-006702-ekf6mja9	1049	4	CD46mRNA	CD46mRNA	NNP
cord-006702-ekf6mja9	1049	5	expression	expression	NN
cord-006702-ekf6mja9	1049	6	in	in	IN
cord-006702-ekf6mja9	1049	7	peripheral	peripheral	JJ
cord-006702-ekf6mja9	1049	8	mononuclear	mononuclear	JJ
cord-006702-ekf6mja9	1049	9	cells	cell	NNS
cord-006702-ekf6mja9	1049	10	of	of	IN
cord-006702-ekf6mja9	1049	11	patients	patient	NNS
cord-006702-ekf6mja9	1049	12	with	with	IN
cord-006702-ekf6mja9	1049	13	progressive	progressive	JJ
cord-006702-ekf6mja9	1049	14	IgA	IgA	NNP
cord-006702-ekf6mja9	1049	15	nephropathy	nephropathy	NN
cord-006702-ekf6mja9	1049	16	.	.	.
cord-006702-ekf6mja9	1050	1	R.	R.	NNP
cord-006702-ekf6mja9	1050	2	Coppo	Coppo	NNP
cord-006702-ekf6mja9	1050	3	(	(	-LRB-
cord-006702-ekf6mja9	1050	4	1	1	CD
cord-006702-ekf6mja9	1050	5	)	)	-RRB-
cord-006702-ekf6mja9	1050	6	,	,	,
cord-006702-ekf6mja9	1050	7	L.	L.	NNP
cord-006702-ekf6mja9	1050	8	Peruzzi	Peruzzi	NNP
cord-006702-ekf6mja9	1050	9	(	(	-LRB-
cord-006702-ekf6mja9	1050	10	1	1	CD
cord-006702-ekf6mja9	1050	11	)	)	-RRB-
cord-006702-ekf6mja9	1050	12	,	,	,
cord-006702-ekf6mja9	1050	13	E.	E.	NNP
cord-006702-ekf6mja9	1050	14	Loiacono	Loiacono	NNP
cord-006702-ekf6mja9	1050	15	(	(	-LRB-
cord-006702-ekf6mja9	1050	16	1	1	CD
cord-006702-ekf6mja9	1050	17	)	)	-RRB-
cord-006702-ekf6mja9	1050	18	,	,	,
cord-006702-ekf6mja9	1050	19	M.	M.	NNP
cord-006702-ekf6mja9	1050	20	Bergallo	Bergallo	NNP
cord-006702-ekf6mja9	1050	21	(	(	-LRB-
cord-006702-ekf6mja9	1050	22	1	1	CD
cord-006702-ekf6mja9	1050	23	)	)	-RRB-
cord-006702-ekf6mja9	1050	24	,	,	,
cord-006702-ekf6mja9	1050	25	M.L.	M.L.	NNP
cord-006702-ekf6mja9	1050	26	Russo	Russo	NNP
cord-006702-ekf6mja9	1050	27	(	(	-LRB-
cord-006702-ekf6mja9	1050	28	1	1	CD
cord-006702-ekf6mja9	1050	29	)	)	-RRB-
cord-006702-ekf6mja9	1050	30	,	,	,
cord-006702-ekf6mja9	1050	31	A.	A.	NNP
cord-006702-ekf6mja9	1050	32	Krutova	Krutova	NNP
cord-006702-ekf6mja9	1050	33	(	(	-LRB-
cord-006702-ekf6mja9	1050	34	2	2	CD
cord-006702-ekf6mja9	1050	35	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1050	36	:	:	:
cord-006702-ekf6mja9	1050	37	Report	report	VB
cord-006702-ekf6mja9	1050	38	a	a	DT
cord-006702-ekf6mja9	1050	39	case	case	NN
cord-006702-ekf6mja9	1050	40	of	of	IN
cord-006702-ekf6mja9	1050	41	vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1050	42	reflux	reflux	NN
cord-006702-ekf6mja9	1050	43	degree	degree	NN
cord-006702-ekf6mja9	1050	44	IV	IV	NNP
cord-006702-ekf6mja9	1050	45	in	in	IN
cord-006702-ekf6mja9	1050	46	child	child	NN
cord-006702-ekf6mja9	1050	47	treated	treat	VBN
cord-006702-ekf6mja9	1050	48	conservatively	conservatively	RB
cord-006702-ekf6mja9	1050	49	Methods	method	NNS
cord-006702-ekf6mja9	1050	50	:	:	:
cord-006702-ekf6mja9	1050	51	Review	Review	NNP
cord-006702-ekf6mja9	1050	52	of	of	IN
cord-006702-ekf6mja9	1050	53	medical	medical	JJ
cord-006702-ekf6mja9	1050	54	record	record	NN
cord-006702-ekf6mja9	1050	55	provided	provide	VBN
cord-006702-ekf6mja9	1050	56	by	by	IN
cord-006702-ekf6mja9	1050	57	Western	Western	NNP
cord-006702-ekf6mja9	1050	58	Paraná	Paraná	NNP
cord-006702-ekf6mja9	1050	59	University	University	NNP
cord-006702-ekf6mja9	1050	60	Hospital	Hospital	NNP
cord-006702-ekf6mja9	1050	61	Results	Results	NNPS
cord-006702-ekf6mja9	1050	62	:	:	:
cord-006702-ekf6mja9	1050	63	Y.B.S.	Y.B.S.	NNP
cord-006702-ekf6mja9	1050	64	two	two	CD
cord-006702-ekf6mja9	1050	65	years	year	NNS
cord-006702-ekf6mja9	1050	66	-	-	HYPH
cord-006702-ekf6mja9	1050	67	old	old	JJ
cord-006702-ekf6mja9	1050	68	,	,	,
cord-006702-ekf6mja9	1050	69	reporting	report	VBG
cord-006702-ekf6mja9	1050	70	fever	fever	NN
cord-006702-ekf6mja9	1050	71	of	of	IN
cord-006702-ekf6mja9	1050	72	40	40	CD
cord-006702-ekf6mja9	1050	73	°	°	NN
cord-006702-ekf6mja9	1050	74	C	c	NN
cord-006702-ekf6mja9	1050	75	,	,	,
cord-006702-ekf6mja9	1050	76	associated	associate	VBN
cord-006702-ekf6mja9	1050	77	with	with	IN
cord-006702-ekf6mja9	1050	78	chills	chill	NNS
cord-006702-ekf6mja9	1050	79	,	,	,
cord-006702-ekf6mja9	1050	80	weakness	weakness	NN
cord-006702-ekf6mja9	1050	81	for	for	IN
cord-006702-ekf6mja9	1050	82	3	3	CD
cord-006702-ekf6mja9	1050	83	days	day	NNS
cord-006702-ekf6mja9	1050	84	.	.	.
cord-006702-ekf6mja9	1051	1	It	-PRON-	PRP
cord-006702-ekf6mja9	1051	2	evolved	evolve	VBD
cord-006702-ekf6mja9	1051	3	with	with	IN
cord-006702-ekf6mja9	1051	4	emesis	emesis	NN
cord-006702-ekf6mja9	1051	5	,	,	,
cord-006702-ekf6mja9	1051	6	appetite	appetite	NN
cord-006702-ekf6mja9	1051	7	loss	loss	NN
cord-006702-ekf6mja9	1051	8	,	,	,
cord-006702-ekf6mja9	1051	9	pain	pain	NN
cord-006702-ekf6mja9	1051	10	in	in	IN
cord-006702-ekf6mja9	1051	11	hypogastric	hypogastric	JJ
cord-006702-ekf6mja9	1051	12	and	and	CC
cord-006702-ekf6mja9	1051	13	discomfort	discomfort	NN
cord-006702-ekf6mja9	1051	14	when	when	WRB
cord-006702-ekf6mja9	1051	15	urinating	urinate	VBG
cord-006702-ekf6mja9	1051	16	,	,	,
cord-006702-ekf6mja9	1051	17	but	but	CC
cord-006702-ekf6mja9	1051	18	the	the	DT
cord-006702-ekf6mja9	1051	19	urine	urine	NN
cord-006702-ekf6mja9	1051	20	had	have	VBD
cord-006702-ekf6mja9	1051	21	normal	normal	JJ
cord-006702-ekf6mja9	1051	22	color	color	NN
cord-006702-ekf6mja9	1051	23	.	.	.
cord-006702-ekf6mja9	1052	1	Gentamicin	gentamicin	NN
cord-006702-ekf6mja9	1052	2	associated	associate	VBN
cord-006702-ekf6mja9	1052	3	with	with	IN
cord-006702-ekf6mja9	1052	4	ceftriaxone	ceftriaxone	NN
cord-006702-ekf6mja9	1052	5	was	be	VBD
cord-006702-ekf6mja9	1052	6	started	start	VBN
cord-006702-ekf6mja9	1052	7	for	for	IN
cord-006702-ekf6mja9	1052	8	pyelonephritis	pyelonephritis	NN
cord-006702-ekf6mja9	1052	9	and	and	CC
cord-006702-ekf6mja9	1052	10	used	use	VBN
cord-006702-ekf6mja9	1052	11	for	for	IN
cord-006702-ekf6mja9	1052	12	seven	seven	CD
cord-006702-ekf6mja9	1052	13	days	day	NNS
cord-006702-ekf6mja9	1052	14	.	.	.
cord-006702-ekf6mja9	1053	1	After	after	IN
cord-006702-ekf6mja9	1053	2	the	the	DT
cord-006702-ekf6mja9	1053	3	end	end	NN
cord-006702-ekf6mja9	1053	4	of	of	IN
cord-006702-ekf6mja9	1053	5	therapy	therapy	NN
cord-006702-ekf6mja9	1053	6	were	be	VBD
cord-006702-ekf6mja9	1053	7	requested	request	VBN
cord-006702-ekf6mja9	1053	8	two	two	CD
cord-006702-ekf6mja9	1053	9	urine	urine	NN
cord-006702-ekf6mja9	1053	10	cultures	culture	NNS
cord-006702-ekf6mja9	1053	11	and	and	CC
cord-006702-ekf6mja9	1053	12	both	both	DT
cord-006702-ekf6mja9	1053	13	came	come	VBD
cord-006702-ekf6mja9	1053	14	negative	negative	JJ
cord-006702-ekf6mja9	1053	15	.	.	.
cord-006702-ekf6mja9	1054	1	Urethrocystography	Urethrocystography	NNP
cord-006702-ekf6mja9	1054	2	was	be	VBD
cord-006702-ekf6mja9	1054	3	requested	request	VBN
cord-006702-ekf6mja9	1054	4	and	and	CC
cord-006702-ekf6mja9	1054	5	showed	show	VBD
cord-006702-ekf6mja9	1054	6	a	a	DT
cord-006702-ekf6mja9	1054	7	vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1054	8	reflux	reflux	NN
cord-006702-ekf6mja9	1054	9	right	right	JJ
cord-006702-ekf6mja9	1054	10	degree	degree	NN
cord-006702-ekf6mja9	1054	11	IV	IV	NNP
cord-006702-ekf6mja9	1054	12	.	.	.
cord-006702-ekf6mja9	1055	1	Started	start	VBN
cord-006702-ekf6mja9	1055	2	using	use	VBG
cord-006702-ekf6mja9	1055	3	nitrofurantoin	nitrofurantoin	NNP
cord-006702-ekf6mja9	1055	4	5	5	CD
cord-006702-ekf6mja9	1055	5	mg	mg	NNP
cord-006702-ekf6mja9	1055	6	once	once	RB
cord-006702-ekf6mja9	1055	7	a	a	DT
cord-006702-ekf6mja9	1055	8	day	day	NN
cord-006702-ekf6mja9	1055	9	.	.	.
cord-006702-ekf6mja9	1056	1	The	the	DT
cord-006702-ekf6mja9	1056	2	patient	patient	NN
cord-006702-ekf6mja9	1056	3	was	be	VBD
cord-006702-ekf6mja9	1056	4	discharged	discharge	VBN
cord-006702-ekf6mja9	1056	5	nine	nine	CD
cord-006702-ekf6mja9	1056	6	days	day	NNS
cord-006702-ekf6mja9	1056	7	after	after	RB
cord-006702-ekf6mja9	1056	8	.	.	.
cord-006702-ekf6mja9	1057	1	Six	six	CD
cord-006702-ekf6mja9	1057	2	months	month	NNS
cord-006702-ekf6mja9	1057	3	after	after	IN
cord-006702-ekf6mja9	1057	4	the	the	DT
cord-006702-ekf6mja9	1057	5	episode	episode	NN
cord-006702-ekf6mja9	1057	6	,	,	,
cord-006702-ekf6mja9	1057	7	scintigraphy	scintigraphy	NNP
cord-006702-ekf6mja9	1057	8	showed	show	VBD
cord-006702-ekf6mja9	1057	9	a	a	DT
cord-006702-ekf6mja9	1057	10	slight	slight	JJ
cord-006702-ekf6mja9	1057	11	tubular	tubular	JJ
cord-006702-ekf6mja9	1057	12	function	function	NN
cord-006702-ekf6mja9	1057	13	impairment	impairment	NN
cord-006702-ekf6mja9	1057	14	and	and	CC
cord-006702-ekf6mja9	1057	15	cortical	cortical	JJ
cord-006702-ekf6mja9	1057	16	shrinkage	shrinkage	NN
cord-006702-ekf6mja9	1057	17	in	in	IN
cord-006702-ekf6mja9	1057	18	the	the	DT
cord-006702-ekf6mja9	1057	19	right	right	JJ
cord-006702-ekf6mja9	1057	20	kidney	kidney	NN
cord-006702-ekf6mja9	1057	21	.	.	.
cord-006702-ekf6mja9	1058	1	The	the	DT
cord-006702-ekf6mja9	1058	2	current	current	JJ
cord-006702-ekf6mja9	1058	3	scan	scan	NN
cord-006702-ekf6mja9	1058	4	showed	show	VBD
cord-006702-ekf6mja9	1058	5	both	both	DT
cord-006702-ekf6mja9	1058	6	kidneys	kidney	NNS
cord-006702-ekf6mja9	1058	7	with	with	IN
cord-006702-ekf6mja9	1058	8	preserved	preserve	VBN
cord-006702-ekf6mja9	1058	9	tubular	tubular	JJ
cord-006702-ekf6mja9	1058	10	function	function	NN
cord-006702-ekf6mja9	1058	11	and	and	CC
cord-006702-ekf6mja9	1058	12	no	no	DT
cord-006702-ekf6mja9	1058	13	cortical	cortical	JJ
cord-006702-ekf6mja9	1058	14	lesions	lesion	NNS
cord-006702-ekf6mja9	1058	15	;	;	:
cord-006702-ekf6mja9	1058	16	and	and	CC
cord-006702-ekf6mja9	1058	17	indirect	indirect	JJ
cord-006702-ekf6mja9	1058	18	radionuclide	radionuclide	NN
cord-006702-ekf6mja9	1058	19	cystography	cystography	NN
cord-006702-ekf6mja9	1058	20	presented	present	VBD
cord-006702-ekf6mja9	1058	21	absence	absence	NN
cord-006702-ekf6mja9	1058	22	of	of	IN
cord-006702-ekf6mja9	1058	23	bilateral	bilateral	JJ
cord-006702-ekf6mja9	1058	24	vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1058	25	reflux	reflux	NN
cord-006702-ekf6mja9	1058	26	.	.	.
cord-006702-ekf6mja9	1059	1	In	in	IN
cord-006702-ekf6mja9	1059	2	October	October	NNP
cord-006702-ekf6mja9	1059	3	2015	2015	CD
cord-006702-ekf6mja9	1059	4	,	,	,
cord-006702-ekf6mja9	1059	5	the	the	DT
cord-006702-ekf6mja9	1059	6	patient	patient	NN
cord-006702-ekf6mja9	1059	7	was	be	VBD
cord-006702-ekf6mja9	1059	8	discharged	discharge	VBN
cord-006702-ekf6mja9	1059	9	from	from	IN
cord-006702-ekf6mja9	1059	10	the	the	DT
cord-006702-ekf6mja9	1059	11	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1059	12	nephrology	nephrology	NN
cord-006702-ekf6mja9	1059	13	not	not	RB
cord-006702-ekf6mja9	1059	14	making	make	VBG
cord-006702-ekf6mja9	1059	15	more	more	JJR
cord-006702-ekf6mja9	1059	16	use	use	NN
cord-006702-ekf6mja9	1059	17	of	of	IN
cord-006702-ekf6mja9	1059	18	nitrofurantoin	nitrofurantoin	NNP
cord-006702-ekf6mja9	1059	19	.	.	.
cord-006702-ekf6mja9	1060	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1060	2	:	:	:
cord-006702-ekf6mja9	1061	1	Vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1061	2	reflux	reflux	NN
cord-006702-ekf6mja9	1061	3	(	(	-LRB-
cord-006702-ekf6mja9	1061	4	VUR	VUR	NNP
cord-006702-ekf6mja9	1061	5	)	)	-RRB-
cord-006702-ekf6mja9	1061	6	is	be	VBZ
cord-006702-ekf6mja9	1061	7	a	a	DT
cord-006702-ekf6mja9	1061	8	common	common	JJ
cord-006702-ekf6mja9	1061	9	urologic	urologic	JJ
cord-006702-ekf6mja9	1061	10	disease	disease	NN
cord-006702-ekf6mja9	1061	11	in	in	IN
cord-006702-ekf6mja9	1061	12	childhood	childhood	NN
cord-006702-ekf6mja9	1061	13	.	.	.
cord-006702-ekf6mja9	1062	1	The	the	DT
cord-006702-ekf6mja9	1062	2	prevalence	prevalence	NN
cord-006702-ekf6mja9	1062	3	in	in	IN
cord-006702-ekf6mja9	1062	4	patients	patient	NNS
cord-006702-ekf6mja9	1062	5	presenting	present	VBG
cord-006702-ekf6mja9	1062	6	urinary	urinary	JJ
cord-006702-ekf6mja9	1062	7	tract	tract	NN
cord-006702-ekf6mja9	1062	8	infections	infection	NNS
cord-006702-ekf6mja9	1062	9	(	(	-LRB-
cord-006702-ekf6mja9	1062	10	UTI	UTI	NNP
cord-006702-ekf6mja9	1062	11	)	)	-RRB-
cord-006702-ekf6mja9	1062	12	ranges	range	VBZ
cord-006702-ekf6mja9	1062	13	from	from	IN
cord-006702-ekf6mja9	1062	14	20	20	CD
cord-006702-ekf6mja9	1062	15	%	%	NN
cord-006702-ekf6mja9	1062	16	to	to	TO
cord-006702-ekf6mja9	1062	17	60	60	CD
cord-006702-ekf6mja9	1062	18	%	%	NN
cord-006702-ekf6mja9	1062	19	.	.	.
cord-006702-ekf6mja9	1063	1	UTI	UTI	NNP
cord-006702-ekf6mja9	1063	2	and	and	CC
cord-006702-ekf6mja9	1063	3	VUR	VUR	NNP
cord-006702-ekf6mja9	1063	4	are	be	VBP
cord-006702-ekf6mja9	1063	5	risk	risk	NN
cord-006702-ekf6mja9	1063	6	factors	factor	NNS
cord-006702-ekf6mja9	1063	7	for	for	IN
cord-006702-ekf6mja9	1063	8	permanent	permanent	JJ
cord-006702-ekf6mja9	1063	9	kidney	kidney	NN
cord-006702-ekf6mja9	1063	10	damage	damage	NN
cord-006702-ekf6mja9	1063	11	and	and	CC
cord-006702-ekf6mja9	1063	12	renal	renal	JJ
cord-006702-ekf6mja9	1063	13	scars	scar	NNS
cord-006702-ekf6mja9	1063	14	,	,	,
cord-006702-ekf6mja9	1063	15	amongst	amongst	IN
cord-006702-ekf6mja9	1063	16	them	-PRON-	PRP
cord-006702-ekf6mja9	1063	17	5%-15	5%-15	CD
cord-006702-ekf6mja9	1063	18	%	%	NN
cord-006702-ekf6mja9	1063	19	occur	occur	VBP
cord-006702-ekf6mja9	1063	20	at	at	IN
cord-006702-ekf6mja9	1063	21	the	the	DT
cord-006702-ekf6mja9	1063	22	first	first	JJ
cord-006702-ekf6mja9	1063	23	ITU	ITU	NNP
cord-006702-ekf6mja9	1063	24	.	.	.
cord-006702-ekf6mja9	1064	1	Urological	urological	JJ
cord-006702-ekf6mja9	1064	2	studies	study	NNS
cord-006702-ekf6mja9	1064	3	are	be	VBP
cord-006702-ekf6mja9	1064	4	recommended	recommend	VBN
cord-006702-ekf6mja9	1064	5	at	at	IN
cord-006702-ekf6mja9	1064	6	the	the	DT
cord-006702-ekf6mja9	1064	7	time	time	NN
cord-006702-ekf6mja9	1064	8	of	of	IN
cord-006702-ekf6mja9	1064	9	the	the	DT
cord-006702-ekf6mja9	1064	10	first	first	JJ
cord-006702-ekf6mja9	1064	11	acute	acute	JJ
cord-006702-ekf6mja9	1064	12	pyelonephritis	pyelonephritis	NN
cord-006702-ekf6mja9	1064	13	in	in	IN
cord-006702-ekf6mja9	1064	14	children	child	NNS
cord-006702-ekf6mja9	1064	15	of	of	IN
cord-006702-ekf6mja9	1064	16	any	any	DT
cord-006702-ekf6mja9	1064	17	age	age	NN
cord-006702-ekf6mja9	1064	18	.	.	.
cord-006702-ekf6mja9	1065	1	Despite	despite	IN
cord-006702-ekf6mja9	1065	2	of	of	IN
cord-006702-ekf6mja9	1065	3	high	high	JJ
cord-006702-ekf6mja9	1065	4	prevalence	prevalence	NN
cord-006702-ekf6mja9	1065	5	,	,	,
cord-006702-ekf6mja9	1065	6	the	the	DT
cord-006702-ekf6mja9	1065	7	treatment	treatment	NN
cord-006702-ekf6mja9	1065	8	is	be	VBZ
cord-006702-ekf6mja9	1065	9	still	still	RB
cord-006702-ekf6mja9	1065	10	a	a	DT
cord-006702-ekf6mja9	1065	11	discussion	discussion	NN
cord-006702-ekf6mja9	1065	12	.	.	.
cord-006702-ekf6mja9	1066	1	Surgery	surgery	NN
cord-006702-ekf6mja9	1066	2	is	be	VBZ
cord-006702-ekf6mja9	1066	3	curative	curative	JJ
cord-006702-ekf6mja9	1066	4	about	about	IN
cord-006702-ekf6mja9	1066	5	98	98	CD
cord-006702-ekf6mja9	1066	6	%	%	NN
cord-006702-ekf6mja9	1066	7	of	of	IN
cord-006702-ekf6mja9	1066	8	cases	case	NNS
cord-006702-ekf6mja9	1066	9	,	,	,
cord-006702-ekf6mja9	1066	10	however	however	RB
cord-006702-ekf6mja9	1066	11	it	-PRON-	PRP
cord-006702-ekf6mja9	1066	12	is	be	VBZ
cord-006702-ekf6mja9	1066	13	associated	associate	VBN
cord-006702-ekf6mja9	1066	14	with	with	IN
cord-006702-ekf6mja9	1066	15	a	a	DT
cord-006702-ekf6mja9	1066	16	considerable	considerable	JJ
cord-006702-ekf6mja9	1066	17	risk	risk	NN
cord-006702-ekf6mja9	1066	18	.	.	.
cord-006702-ekf6mja9	1067	1	Antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1067	2	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1067	3	to	to	TO
cord-006702-ekf6mja9	1067	4	prevent	prevent	VB
cord-006702-ekf6mja9	1067	5	damage	damage	NN
cord-006702-ekf6mja9	1067	6	is	be	VBZ
cord-006702-ekf6mja9	1067	7	controversy	controversy	NN
cord-006702-ekf6mja9	1067	8	because	because	IN
cord-006702-ekf6mja9	1067	9	of	of	IN
cord-006702-ekf6mja9	1067	10	low	low	JJ
cord-006702-ekf6mja9	1067	11	compliance	compliance	NN
cord-006702-ekf6mja9	1067	12	rates	rate	NNS
cord-006702-ekf6mja9	1067	13	and	and	CC
cord-006702-ekf6mja9	1067	14	side	side	NN
cord-006702-ekf6mja9	1067	15	effects	effect	NNS
cord-006702-ekf6mja9	1067	16	.	.	.
cord-006702-ekf6mja9	1068	1	In	in	IN
cord-006702-ekf6mja9	1068	2	a	a	DT
cord-006702-ekf6mja9	1068	3	retrospective	retrospective	JJ
cord-006702-ekf6mja9	1068	4	recent	recent	JJ
cord-006702-ekf6mja9	1068	5	study	study	NN
cord-006702-ekf6mja9	1068	6	,	,	,
cord-006702-ekf6mja9	1068	7	63,3	63,3	CD
cord-006702-ekf6mja9	1068	8	%	%	NN
cord-006702-ekf6mja9	1068	9	of	of	IN
cord-006702-ekf6mja9	1068	10	the	the	DT
cord-006702-ekf6mja9	1068	11	patients	patient	NNS
cord-006702-ekf6mja9	1068	12	with	with	IN
cord-006702-ekf6mja9	1068	13	VUR	VUR	NNP
cord-006702-ekf6mja9	1068	14	grade	grade	NN
cord-006702-ekf6mja9	1068	15	IV	IV	NNP
cord-006702-ekf6mja9	1068	16	and	and	CC
cord-006702-ekf6mja9	1068	17	V	V	NNP
cord-006702-ekf6mja9	1068	18	were	be	VBD
cord-006702-ekf6mja9	1068	19	conducted	conduct	VBN
cord-006702-ekf6mja9	1068	20	surgically	surgically	RB
cord-006702-ekf6mja9	1068	21	.	.	.
cord-006702-ekf6mja9	1069	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1069	2	present	present	VBP
cord-006702-ekf6mja9	1069	3	a	a	DT
cord-006702-ekf6mja9	1069	4	case	case	NN
cord-006702-ekf6mja9	1069	5	of	of	IN
cord-006702-ekf6mja9	1069	6	UVR	UVR	NNP
cord-006702-ekf6mja9	1069	7	grade	grade	NN
cord-006702-ekf6mja9	1069	8	IV	IV	NNP
cord-006702-ekf6mja9	1069	9	conservatively	conservatively	RB
cord-006702-ekf6mja9	1069	10	treated	treat	VBD
cord-006702-ekf6mja9	1069	11	that	that	WDT
cord-006702-ekf6mja9	1069	12	evolved	evolve	VBD
cord-006702-ekf6mja9	1069	13	for	for	IN
cord-006702-ekf6mja9	1069	14	complete	complete	JJ
cord-006702-ekf6mja9	1069	15	cure	cure	NN
cord-006702-ekf6mja9	1069	16	.	.	.
cord-006702-ekf6mja9	1070	1	6	6	LS
cord-006702-ekf6mja9	1070	2	-	-	SYM
cord-006702-ekf6mja9	1070	3	2.6	2.6	CD
cord-006702-ekf6mja9	1070	4	]	]	-RRB-
cord-006702-ekf6mja9	1070	5	.	.	.
cord-006702-ekf6mja9	1071	1	Seventy	seventy	CD
cord-006702-ekf6mja9	1071	2	-	-	HYPH
cord-006702-ekf6mja9	1071	3	six	six	CD
cord-006702-ekf6mja9	1071	4	percent	percent	NN
cord-006702-ekf6mja9	1071	5	of	of	IN
cord-006702-ekf6mja9	1071	6	all	all	DT
cord-006702-ekf6mja9	1071	7	tests	test	NNS
cord-006702-ekf6mja9	1071	8	were	be	VBD
cord-006702-ekf6mja9	1071	9	X	X	NNS
cord-006702-ekf6mja9	1071	10	-	-	NNS
cord-006702-ekf6mja9	1071	11	rays	ray	NNS
cord-006702-ekf6mja9	1071	12	,	,	,
cord-006702-ekf6mja9	1071	13	and	and	CC
cord-006702-ekf6mja9	1071	14	nuclear	nuclear	JJ
cord-006702-ekf6mja9	1071	15	medicine	medicine	NN
cord-006702-ekf6mja9	1071	16	studies	study	NNS
cord-006702-ekf6mja9	1071	17	accounted	account	VBD
cord-006702-ekf6mja9	1071	18	for	for	IN
cord-006702-ekf6mja9	1071	19	71	71	CD
cord-006702-ekf6mja9	1071	20	%	%	NN
cord-006702-ekf6mja9	1071	21	of	of	IN
cord-006702-ekf6mja9	1071	22	cumulative	cumulative	JJ
cord-006702-ekf6mja9	1071	23	radiation	radiation	NN
cord-006702-ekf6mja9	1071	24	exposure	exposure	NN
cord-006702-ekf6mja9	1071	25	.	.	.
cord-006702-ekf6mja9	1072	1	Less	Less	JJR
cord-006702-ekf6mja9	1072	2	than	than	IN
cord-006702-ekf6mja9	1072	3	5	5	CD
cord-006702-ekf6mja9	1072	4	children	child	NNS
cord-006702-ekf6mja9	1072	5	were	be	VBD
cord-006702-ekf6mja9	1072	6	exposed	expose	VBN
cord-006702-ekf6mja9	1072	7	to	to	IN
cord-006702-ekf6mja9	1072	8	a	a	DT
cord-006702-ekf6mja9	1072	9	potentially	potentially	RB
cord-006702-ekf6mja9	1072	10	toxic	toxic	JJ
cord-006702-ekf6mja9	1072	11	cumulative	cumulative	JJ
cord-006702-ekf6mja9	1072	12	dose	dose	NN
cord-006702-ekf6mja9	1072	13	greater	great	JJR
cord-006702-ekf6mja9	1072	14	than	than	IN
cord-006702-ekf6mja9	1072	15	30	30	CD
cord-006702-ekf6mja9	1072	16	mSv	mSv	NNP
cord-006702-ekf6mja9	1072	17	.	.	.
cord-006702-ekf6mja9	1073	1	Longer	long	JJR
cord-006702-ekf6mja9	1073	2	duration	duration	NN
cord-006702-ekf6mja9	1073	3	of	of	IN
cord-006702-ekf6mja9	1073	4	chronic	chronic	JJ
cord-006702-ekf6mja9	1073	5	kidney	kidney	NN
cord-006702-ekf6mja9	1073	6	disease	disease	NN
cord-006702-ekf6mja9	1073	7	(	(	-LRB-
cord-006702-ekf6mja9	1073	8	CKD	CKD	NNP
cord-006702-ekf6mja9	1073	9	)	)	-RRB-
cord-006702-ekf6mja9	1073	10	before	before	IN
cord-006702-ekf6mja9	1073	11	transplant	transplant	NN
cord-006702-ekf6mja9	1073	12	was	be	VBD
cord-006702-ekf6mja9	1073	13	correlated	correlate	VBN
cord-006702-ekf6mja9	1073	14	with	with	IN
cord-006702-ekf6mja9	1073	15	greater	great	JJR
cord-006702-ekf6mja9	1073	16	cumulative	cumulative	JJ
cord-006702-ekf6mja9	1073	17	effective	effective	JJ
cord-006702-ekf6mja9	1073	18	dose	dose	NN
cord-006702-ekf6mja9	1073	19	(	(	-LRB-
cord-006702-ekf6mja9	1073	20	table	table	NN
cord-006702-ekf6mja9	1073	21	)	)	-RRB-
cord-006702-ekf6mja9	1073	22	.	.	.
cord-006702-ekf6mja9	1074	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1074	2	:	:	:
cord-006702-ekf6mja9	1074	3	Children	child	NNS
cord-006702-ekf6mja9	1074	4	that	that	WDT
cord-006702-ekf6mja9	1074	5	receive	receive	VBP
cord-006702-ekf6mja9	1074	6	kidney	kidney	NN
cord-006702-ekf6mja9	1074	7	transplants	transplant	NNS
cord-006702-ekf6mja9	1074	8	undergo	undergo	VBP
cord-006702-ekf6mja9	1074	9	many	many	JJ
cord-006702-ekf6mja9	1074	10	imaging	imaging	NN
cord-006702-ekf6mja9	1074	11	studies	study	NNS
cord-006702-ekf6mja9	1074	12	with	with	IN
cord-006702-ekf6mja9	1074	13	radiation	radiation	NN
cord-006702-ekf6mja9	1074	14	exposure	exposure	NN
cord-006702-ekf6mja9	1074	15	predominantly	predominantly	RB
cord-006702-ekf6mja9	1074	16	from	from	IN
cord-006702-ekf6mja9	1074	17	nuclear	nuclear	JJ
cord-006702-ekf6mja9	1074	18	medicine	medicine	NN
cord-006702-ekf6mja9	1074	19	studies	study	NNS
cord-006702-ekf6mja9	1074	20	,	,	,
cord-006702-ekf6mja9	1074	21	especially	especially	RB
cord-006702-ekf6mja9	1074	22	those	those	DT
cord-006702-ekf6mja9	1074	23	that	that	WDT
cord-006702-ekf6mja9	1074	24	have	have	VBP
cord-006702-ekf6mja9	1074	25	longer	long	JJR
cord-006702-ekf6mja9	1074	26	CKD	CKD	NNP
cord-006702-ekf6mja9	1074	27	duration	duration	NN
cord-006702-ekf6mja9	1074	28	.	.	.
cord-006702-ekf6mja9	1075	1	Greater	great	JJR
cord-006702-ekf6mja9	1075	2	awareness	awareness	NN
cord-006702-ekf6mja9	1075	3	of	of	IN
cord-006702-ekf6mja9	1075	4	cumulative	cumulative	JJ
cord-006702-ekf6mja9	1075	5	ionizing	ionize	VBG
cord-006702-ekf6mja9	1075	6	radiation	radiation	NN
cord-006702-ekf6mja9	1075	7	is	be	VBZ
cord-006702-ekf6mja9	1075	8	needed	need	VBN
cord-006702-ekf6mja9	1075	9	to	to	TO
cord-006702-ekf6mja9	1075	10	minimize	minimize	VB
cord-006702-ekf6mja9	1075	11	exposure	exposure	NN
cord-006702-ekf6mja9	1075	12	as	as	IN
cord-006702-ekf6mja9	1075	13	children	child	NNS
cord-006702-ekf6mja9	1075	14	age	age	VBP
cord-006702-ekf6mja9	1075	15	into	into	IN
cord-006702-ekf6mja9	1075	16	adulthood	adulthood	NN
cord-006702-ekf6mja9	1075	17	.	.	.
cord-006702-ekf6mja9	1076	1	&	&	CC
cord-006702-ekf6mja9	1076	2	Objectives	Objectives	NNP
cord-006702-ekf6mja9	1076	3	:	:	:
cord-006702-ekf6mja9	1077	1	A	a	DT
cord-006702-ekf6mja9	1077	2	short	short	JJ
cord-006702-ekf6mja9	1077	3	stature	stature	NN
cord-006702-ekf6mja9	1077	4	as	as	IN
cord-006702-ekf6mja9	1077	5	a	a	DT
cord-006702-ekf6mja9	1077	6	result	result	NN
cord-006702-ekf6mja9	1077	7	of	of	IN
cord-006702-ekf6mja9	1077	8	poor	poor	JJ
cord-006702-ekf6mja9	1077	9	growth	growth	NN
cord-006702-ekf6mja9	1077	10	is	be	VBZ
cord-006702-ekf6mja9	1077	11	common	common	JJ
cord-006702-ekf6mja9	1077	12	in	in	IN
cord-006702-ekf6mja9	1077	13	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1077	14	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1077	15	and	and	CC
cord-006702-ekf6mja9	1077	16	has	have	VBZ
cord-006702-ekf6mja9	1077	17	been	be	VBN
cord-006702-ekf6mja9	1077	18	associated	associate	VBN
cord-006702-ekf6mja9	1077	19	with	with	IN
cord-006702-ekf6mja9	1077	20	adverse	adverse	JJ
cord-006702-ekf6mja9	1077	21	psychosocial	psychosocial	JJ
cord-006702-ekf6mja9	1077	22	and	and	CC
cord-006702-ekf6mja9	1077	23	clinical	clinical	JJ
cord-006702-ekf6mja9	1077	24	outcomes	outcome	NNS
cord-006702-ekf6mja9	1077	25	.	.	.
cord-006702-ekf6mja9	1078	1	Through	through	IN
cord-006702-ekf6mja9	1078	2	improved	improve	VBN
cord-006702-ekf6mja9	1078	3	management	management	NN
cord-006702-ekf6mja9	1078	4	of	of	IN
cord-006702-ekf6mja9	1078	5	growth	growth	NN
cord-006702-ekf6mja9	1078	6	failure	failure	NN
cord-006702-ekf6mja9	1078	7	,	,	,
cord-006702-ekf6mja9	1078	8	its	-PRON-	PRP$
cord-006702-ekf6mja9	1078	9	prevalence	prevalence	NN
cord-006702-ekf6mja9	1078	10	after	after	IN
cord-006702-ekf6mja9	1078	11	kidney	kidney	NN
cord-006702-ekf6mja9	1078	12	transplantation	transplantation	NN
cord-006702-ekf6mja9	1078	13	(	(	-LRB-
cord-006702-ekf6mja9	1078	14	KT	KT	NNP
cord-006702-ekf6mja9	1078	15	)	)	-RRB-
cord-006702-ekf6mja9	1078	16	is	be	VBZ
cord-006702-ekf6mja9	1078	17	supposed	suppose	VBN
cord-006702-ekf6mja9	1078	18	to	to	TO
cord-006702-ekf6mja9	1078	19	have	have	VB
cord-006702-ekf6mja9	1078	20	decreased	decrease	VBN
cord-006702-ekf6mja9	1078	21	over	over	IN
cord-006702-ekf6mja9	1078	22	time	time	NN
cord-006702-ekf6mja9	1078	23	.	.	.
cord-006702-ekf6mja9	1079	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1079	2	aim	aim	VBP
cord-006702-ekf6mja9	1079	3	to	to	TO
cord-006702-ekf6mja9	1079	4	analyze	analyze	VB
cord-006702-ekf6mja9	1079	5	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	1079	6	growth	growth	NN
cord-006702-ekf6mja9	1079	7	after	after	IN
cord-006702-ekf6mja9	1079	8	KT	KT	NNP
cord-006702-ekf6mja9	1079	9	,	,	,
cord-006702-ekf6mja9	1079	10	trends	trend	NNS
cord-006702-ekf6mja9	1079	11	over	over	IN
cord-006702-ekf6mja9	1079	12	time	time	NN
cord-006702-ekf6mja9	1079	13	,	,	,
cord-006702-ekf6mja9	1079	14	and	and	CC
cord-006702-ekf6mja9	1079	15	to	to	TO
cord-006702-ekf6mja9	1079	16	identify	identify	VB
cord-006702-ekf6mja9	1079	17	potential	potential	JJ
cord-006702-ekf6mja9	1079	18	determinants	determinant	NNS
cord-006702-ekf6mja9	1079	19	of	of	IN
cord-006702-ekf6mja9	1079	20	height	height	NN
cord-006702-ekf6mja9	1079	21	SDS	SDS	NNP
cord-006702-ekf6mja9	1079	22	in	in	IN
cord-006702-ekf6mja9	1079	23	a	a	DT
cord-006702-ekf6mja9	1079	24	large	large	JJ
cord-006702-ekf6mja9	1079	25	cohort	cohort	NN
cord-006702-ekf6mja9	1079	26	of	of	IN
cord-006702-ekf6mja9	1079	27	transplanted	transplanted	JJ
cord-006702-ekf6mja9	1079	28	children	child	NNS
cord-006702-ekf6mja9	1079	29	using	use	VBG
cord-006702-ekf6mja9	1079	30	data	datum	NNS
cord-006702-ekf6mja9	1079	31	from	from	IN
cord-006702-ekf6mja9	1079	32	the	the	DT
cord-006702-ekf6mja9	1079	33	ESPN	ESPN	NNP
cord-006702-ekf6mja9	1079	34	/	/	SYM
cord-006702-ekf6mja9	1079	35	ERA	ERA	NNP
cord-006702-ekf6mja9	1079	36	-	-	HYPH
cord-006702-ekf6mja9	1079	37	EDTA	EDTA	NNP
cord-006702-ekf6mja9	1079	38	Registry	Registry	NNP
cord-006702-ekf6mja9	1079	39	.	.	.
cord-006702-ekf6mja9	1080	1	Methods	method	NNS
cord-006702-ekf6mja9	1080	2	:	:	:
cord-006702-ekf6mja9	1081	1	A	a	DT
cord-006702-ekf6mja9	1081	2	total	total	NN
cord-006702-ekf6mja9	1081	3	of	of	IN
cord-006702-ekf6mja9	1081	4	3,492	3,492	CD
cord-006702-ekf6mja9	1081	5	patients	patient	NNS
cord-006702-ekf6mja9	1081	6	from	from	IN
cord-006702-ekf6mja9	1081	7	23	23	CD
cord-006702-ekf6mja9	1081	8	European	european	JJ
cord-006702-ekf6mja9	1081	9	countries	country	NNS
cord-006702-ekf6mja9	1081	10	transplanted	transplant	VBN
cord-006702-ekf6mja9	1081	11	before	before	IN
cord-006702-ekf6mja9	1081	12	18	18	CD
cord-006702-ekf6mja9	1081	13	years	year	NNS
cord-006702-ekf6mja9	1081	14	of	of	IN
cord-006702-ekf6mja9	1081	15	age	age	NN
cord-006702-ekf6mja9	1081	16	between	between	IN
cord-006702-ekf6mja9	1081	17	1990	1990	CD
cord-006702-ekf6mja9	1081	18	and	and	CC
cord-006702-ekf6mja9	1081	19	2012	2012	CD
cord-006702-ekf6mja9	1081	20	,	,	,
cord-006702-ekf6mja9	1081	21	with	with	IN
cord-006702-ekf6mja9	1081	22	available	available	JJ
cord-006702-ekf6mja9	1081	23	longitudinal	longitudinal	JJ
cord-006702-ekf6mja9	1081	24	follow	follow	NN
cord-006702-ekf6mja9	1081	25	-	-	HYPH
cord-006702-ekf6mja9	1081	26	up	up	NN
cord-006702-ekf6mja9	1081	27	were	be	VBD
cord-006702-ekf6mja9	1081	28	included	include	VBN
cord-006702-ekf6mja9	1081	29	.	.	.
cord-006702-ekf6mja9	1082	1	Height	Height	NNP
cord-006702-ekf6mja9	1082	2	Standard	Standard	NNP
cord-006702-ekf6mja9	1082	3	Deviation	Deviation	NNP
cord-006702-ekf6mja9	1082	4	Scores	score	NNS
cord-006702-ekf6mja9	1082	5	(	(	-LRB-
cord-006702-ekf6mja9	1082	6	SDS	SDS	NNP
cord-006702-ekf6mja9	1082	7	)	)	-RRB-
cord-006702-ekf6mja9	1082	8	were	be	VBD
cord-006702-ekf6mja9	1082	9	calculated	calculate	VBN
cord-006702-ekf6mja9	1082	10	using	use	VBG
cord-006702-ekf6mja9	1082	11	recent	recent	JJ
cord-006702-ekf6mja9	1082	12	national	national	JJ
cord-006702-ekf6mja9	1082	13	growth	growth	NN
cord-006702-ekf6mja9	1082	14	charts	chart	NNS
cord-006702-ekf6mja9	1082	15	or	or	CC
cord-006702-ekf6mja9	1082	16	European	european	JJ
cord-006702-ekf6mja9	1082	17	growth	growth	NN
cord-006702-ekf6mja9	1082	18	charts	chart	NNS
cord-006702-ekf6mja9	1082	19	for	for	IN
cord-006702-ekf6mja9	1082	20	countries	country	NNS
cord-006702-ekf6mja9	1082	21	without	without	IN
cord-006702-ekf6mja9	1082	22	recent	recent	JJ
cord-006702-ekf6mja9	1082	23	reference	reference	NN
cord-006702-ekf6mja9	1082	24	data	datum	NNS
cord-006702-ekf6mja9	1082	25	.	.	.
cord-006702-ekf6mja9	1083	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1083	2	used	use	VBD
cord-006702-ekf6mja9	1083	3	generalized	generalized	JJ
cord-006702-ekf6mja9	1083	4	equation	equation	NN
cord-006702-ekf6mja9	1083	5	models	model	NNS
cord-006702-ekf6mja9	1083	6	to	to	TO
cord-006702-ekf6mja9	1083	7	estimate	estimate	VB
cord-006702-ekf6mja9	1083	8	the	the	DT
cord-006702-ekf6mja9	1083	9	prevalence	prevalence	NN
cord-006702-ekf6mja9	1083	10	of	of	IN
cord-006702-ekf6mja9	1083	11	growth	growth	NN
cord-006702-ekf6mja9	1083	12	retardation	retardation	NN
cord-006702-ekf6mja9	1083	13	and	and	CC
cord-006702-ekf6mja9	1083	14	linear	linear	JJ
cord-006702-ekf6mja9	1083	15	mixed	mixed	JJ
cord-006702-ekf6mja9	1083	16	models	model	NNS
cord-006702-ekf6mja9	1083	17	to	to	TO
cord-006702-ekf6mja9	1083	18	calculate	calculate	VB
cord-006702-ekf6mja9	1083	19	adjusted	adjust	VBN
cord-006702-ekf6mja9	1083	20	mean	mean	NNP
cord-006702-ekf6mja9	1083	21	height	height	NNP
cord-006702-ekf6mja9	1083	22	SDS	SDS	NNP
cord-006702-ekf6mja9	1083	23	and	and	CC
cord-006702-ekf6mja9	1083	24	its	-PRON-	PRP$
cord-006702-ekf6mja9	1083	25	potential	potential	JJ
cord-006702-ekf6mja9	1083	26	determinants	determinant	NNS
cord-006702-ekf6mja9	1083	27	.	.	.
cord-006702-ekf6mja9	1084	1	Results	result	NNS
cord-006702-ekf6mja9	1084	2	:	:	:
cord-006702-ekf6mja9	1085	1	Overall	overall	JJ
cord-006702-ekf6mja9	1085	2	mean	mean	JJ
cord-006702-ekf6mja9	1085	3	adjusted	adjusted	JJ
cord-006702-ekf6mja9	1085	4	height	height	NN
cord-006702-ekf6mja9	1085	5	SDS	SDS	NNP
cord-006702-ekf6mja9	1085	6	post	post	NN
cord-006702-ekf6mja9	1085	7	KT	KT	NNP
cord-006702-ekf6mja9	1085	8	was	be	VBD
cord-006702-ekf6mja9	1085	9	-1.77	-1.77	:
cord-006702-ekf6mja9	1085	10	±	±	CD
cord-006702-ekf6mja9	1085	11	0.04	0.04	CD
cord-006702-ekf6mja9	1085	12	.	.	.
cord-006702-ekf6mja9	1086	1	55	55	CD
cord-006702-ekf6mja9	1086	2	%	%	NN
cord-006702-ekf6mja9	1086	3	of	of	IN
cord-006702-ekf6mja9	1086	4	children	child	NNS
cord-006702-ekf6mja9	1086	5	had	have	VBD
cord-006702-ekf6mja9	1086	6	a	a	DT
cord-006702-ekf6mja9	1086	7	height	height	NN
cord-006702-ekf6mja9	1086	8	SDS	sds	NN
cord-006702-ekf6mja9	1086	9	within	within	IN
cord-006702-ekf6mja9	1086	10	normal	normal	JJ
cord-006702-ekf6mja9	1086	11	range	range	NN
cord-006702-ekf6mja9	1086	12	,	,	,
cord-006702-ekf6mja9	1086	13	28	28	CD
cord-006702-ekf6mja9	1086	14	%	%	NN
cord-006702-ekf6mja9	1086	15	showed	show	VBD
cord-006702-ekf6mja9	1086	16	moderate	moderate	JJ
cord-006702-ekf6mja9	1086	17	,	,	,
cord-006702-ekf6mja9	1086	18	and	and	CC
cord-006702-ekf6mja9	1086	19	17	17	CD
cord-006702-ekf6mja9	1086	20	%	%	NN
cord-006702-ekf6mja9	1086	21	severe	severe	JJ
cord-006702-ekf6mja9	1086	22	growth	growth	NN
cord-006702-ekf6mja9	1086	23	retardation	retardation	NN
cord-006702-ekf6mja9	1086	24	.	.	.
cord-006702-ekf6mja9	1087	1	Girls	girl	NNS
cord-006702-ekf6mja9	1087	2	were	be	VBD
cord-006702-ekf6mja9	1087	3	significantly	significantly	RB
cord-006702-ekf6mja9	1087	4	shorter	short	JJR
cord-006702-ekf6mja9	1087	5	than	than	IN
cord-006702-ekf6mja9	1087	6	boys	boy	NNS
cord-006702-ekf6mja9	1087	7	.	.	.
cord-006702-ekf6mja9	1088	1	In	in	IN
cord-006702-ekf6mja9	1088	2	multivariable	multivariable	JJ
cord-006702-ekf6mja9	1088	3	analysis	analysis	NN
cord-006702-ekf6mja9	1088	4	,	,	,
cord-006702-ekf6mja9	1088	5	living	live	VBG
cord-006702-ekf6mja9	1088	6	donor	donor	NN
cord-006702-ekf6mja9	1088	7	KT	kt	NN
cord-006702-ekf6mja9	1088	8	,	,	,
cord-006702-ekf6mja9	1088	9	steroid	steroid	NN
cord-006702-ekf6mja9	1088	10	free	free	JJ
cord-006702-ekf6mja9	1088	11	immunosuppressive	immunosuppressive	JJ
cord-006702-ekf6mja9	1088	12	regimen	regimen	NN
cord-006702-ekf6mja9	1088	13	,	,	,
cord-006702-ekf6mja9	1088	14	higher	high	JJR
cord-006702-ekf6mja9	1088	15	eGFR	egfr	NN
cord-006702-ekf6mja9	1088	16	,	,	,
cord-006702-ekf6mja9	1088	17	and	and	CC
cord-006702-ekf6mja9	1088	18	not	not	RB
cord-006702-ekf6mja9	1088	19	being	be	VBG
cord-006702-ekf6mja9	1088	20	hypertensive	hypertensive	JJ
cord-006702-ekf6mja9	1088	21	or	or	CC
cord-006702-ekf6mja9	1088	22	anemic	anemic	JJ
cord-006702-ekf6mja9	1088	23	were	be	VBD
cord-006702-ekf6mja9	1088	24	associated	associate	VBN
cord-006702-ekf6mja9	1088	25	with	with	IN
cord-006702-ekf6mja9	1088	26	better	well	JJR
cord-006702-ekf6mja9	1088	27	post	post	JJ
cord-006702-ekf6mja9	1088	28	-	-	JJ
cord-006702-ekf6mja9	1088	29	KT	kt	JJ
cord-006702-ekf6mja9	1088	30	height	height	NN
cord-006702-ekf6mja9	1088	31	SDS	SDS	NNP
cord-006702-ekf6mja9	1088	32	.	.	.
cord-006702-ekf6mja9	1089	1	Patients	patient	NNS
cord-006702-ekf6mja9	1089	2	with	with	IN
cord-006702-ekf6mja9	1089	3	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1089	4	and	and	CC
cord-006702-ekf6mja9	1089	5	metabolic	metabolic	JJ
cord-006702-ekf6mja9	1089	6	disorders	disorder	NNS
cord-006702-ekf6mja9	1089	7	were	be	VBD
cord-006702-ekf6mja9	1089	8	shorter	short	JJR
cord-006702-ekf6mja9	1089	9	compared	compare	VBN
cord-006702-ekf6mja9	1089	10	to	to	IN
cord-006702-ekf6mja9	1089	11	other	other	JJ
cord-006702-ekf6mja9	1089	12	primary	primary	JJ
cord-006702-ekf6mja9	1089	13	renal	renal	JJ
cord-006702-ekf6mja9	1089	14	diseases	disease	NNS
cord-006702-ekf6mja9	1089	15	.	.	.
cord-006702-ekf6mja9	1090	1	Catch	catch	VB
cord-006702-ekf6mja9	1090	2	-	-	HYPH
cord-006702-ekf6mja9	1090	3	up	up	RP
cord-006702-ekf6mja9	1090	4	growth	growth	NN
cord-006702-ekf6mja9	1090	5	by	by	IN
cord-006702-ekf6mja9	1090	6	5	5	CD
cord-006702-ekf6mja9	1090	7	years	year	NNS
cord-006702-ekf6mja9	1091	1	post	post	NNP
cord-006702-ekf6mja9	1091	2	KT	KT	NNP
cord-006702-ekf6mja9	1091	3	was	be	VBD
cord-006702-ekf6mja9	1091	4	observed	observe	VBN
cord-006702-ekf6mja9	1091	5	in	in	IN
cord-006702-ekf6mja9	1091	6	both	both	DT
cord-006702-ekf6mja9	1091	7	boys	boy	NNS
cord-006702-ekf6mja9	1091	8	(	(	-LRB-
cord-006702-ekf6mja9	1091	9	+0.37	+0.37	NNP
cord-006702-ekf6mja9	1091	10	)	)	-RRB-
cord-006702-ekf6mja9	1091	11	and	and	CC
cord-006702-ekf6mja9	1091	12	girls	girl	NNS
cord-006702-ekf6mja9	1091	13	(	(	-LRB-
cord-006702-ekf6mja9	1091	14	+0.33	+0.33	NNP
cord-006702-ekf6mja9	1091	15	SDS	SDS	NNP
cord-006702-ekf6mja9	1091	16	)	)	-RRB-
cord-006702-ekf6mja9	1091	17	.	.	.
cord-006702-ekf6mja9	1092	1	Children	child	NNS
cord-006702-ekf6mja9	1092	2	<	<	XX
cord-006702-ekf6mja9	1092	3	6	6	CD
cord-006702-ekf6mja9	1092	4	years	year	NNS
cord-006702-ekf6mja9	1092	5	were	be	VBD
cord-006702-ekf6mja9	1092	6	shortest	short	JJS
cord-006702-ekf6mja9	1092	7	at	at	IN
cord-006702-ekf6mja9	1092	8	KT	KT	NNP
cord-006702-ekf6mja9	1092	9	and	and	CC
cord-006702-ekf6mja9	1092	10	showed	show	VBD
cord-006702-ekf6mja9	1092	11	the	the	DT
cord-006702-ekf6mja9	1092	12	greatest	great	JJS
cord-006702-ekf6mja9	1092	13	increase	increase	NN
cord-006702-ekf6mja9	1092	14	(	(	-LRB-
cord-006702-ekf6mja9	1092	15	+0.8	+0.8	CD
cord-006702-ekf6mja9	1092	16	)	)	-RRB-
cord-006702-ekf6mja9	1092	17	in	in	IN
cord-006702-ekf6mja9	1092	18	height	height	NNP
cord-006702-ekf6mja9	1092	19	SDS	SDS	NNP
cord-006702-ekf6mja9	1092	20	,	,	,
cord-006702-ekf6mja9	1092	21	whereas	whereas	IN
cord-006702-ekf6mja9	1092	22	there	there	EX
cord-006702-ekf6mja9	1092	23	was	be	VBD
cord-006702-ekf6mja9	1092	24	no	no	DT
cord-006702-ekf6mja9	1092	25	catch	catch	NN
cord-006702-ekf6mja9	1092	26	-	-	HYPH
cord-006702-ekf6mja9	1092	27	up	up	RP
cord-006702-ekf6mja9	1092	28	growth	growth	NN
cord-006702-ekf6mja9	1092	29	in	in	IN
cord-006702-ekf6mja9	1092	30	children	child	NNS
cord-006702-ekf6mja9	1092	31	transplanted	transplant	VBN
cord-006702-ekf6mja9	1092	32	>	>	XX
cord-006702-ekf6mja9	1092	33	12	12	CD
cord-006702-ekf6mja9	1092	34	.	.	.
cord-006702-ekf6mja9	1093	1	Post	post	JJ
cord-006702-ekf6mja9	1093	2	KT	KT	NNP
cord-006702-ekf6mja9	1093	3	growth	growth	NN
cord-006702-ekf6mja9	1093	4	did	do	VBD
cord-006702-ekf6mja9	1093	5	not	not	RB
cord-006702-ekf6mja9	1093	6	improve	improve	VB
cord-006702-ekf6mja9	1093	7	over	over	IN
cord-006702-ekf6mja9	1093	8	time	time	NN
cord-006702-ekf6mja9	1093	9	.	.	.
cord-006702-ekf6mja9	1094	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1094	2	:	:	:
cord-006702-ekf6mja9	1095	1	Catch	catch	VB
cord-006702-ekf6mja9	1095	2	-	-	HYPH
cord-006702-ekf6mja9	1095	3	up	up	RP
cord-006702-ekf6mja9	1095	4	growth	growth	NN
cord-006702-ekf6mja9	1095	5	post	post	NN
cord-006702-ekf6mja9	1095	6	KT	KT	NNP
cord-006702-ekf6mja9	1095	7	remains	remain	VBZ
cord-006702-ekf6mja9	1095	8	limited	limited	JJ
cord-006702-ekf6mja9	1095	9	,	,	,
cord-006702-ekf6mja9	1095	10	was	be	VBD
cord-006702-ekf6mja9	1095	11	mainly	mainly	RB
cord-006702-ekf6mja9	1095	12	observed	observe	VBN
cord-006702-ekf6mja9	1095	13	in	in	IN
cord-006702-ekf6mja9	1095	14	the	the	DT
cord-006702-ekf6mja9	1095	15	youngest	young	JJS
cord-006702-ekf6mja9	1095	16	recipients	recipient	NNS
cord-006702-ekf6mja9	1095	17	,	,	,
cord-006702-ekf6mja9	1095	18	and	and	CC
cord-006702-ekf6mja9	1095	19	did	do	VBD
cord-006702-ekf6mja9	1095	20	not	not	RB
cord-006702-ekf6mja9	1095	21	show	show	VB
cord-006702-ekf6mja9	1095	22	substantial	substantial	JJ
cord-006702-ekf6mja9	1095	23	improvement	improvement	NN
cord-006702-ekf6mja9	1095	24	over	over	IN
cord-006702-ekf6mja9	1095	25	time	time	NN
cord-006702-ekf6mja9	1095	26	,	,	,
cord-006702-ekf6mja9	1095	27	resulting	result	VBG
cord-006702-ekf6mja9	1095	28	in	in	IN
cord-006702-ekf6mja9	1095	29	short	short	JJ
cord-006702-ekf6mja9	1095	30	stature	stature	NN
cord-006702-ekf6mja9	1095	31	in	in	IN
cord-006702-ekf6mja9	1095	32	nearly	nearly	RB
cord-006702-ekf6mja9	1095	33	half	half	NN
cord-006702-ekf6mja9	1095	34	of	of	IN
cord-006702-ekf6mja9	1095	35	transplanted	transplanted	JJ
cord-006702-ekf6mja9	1095	36	children	child	NNS
cord-006702-ekf6mja9	1095	37	in	in	IN
cord-006702-ekf6mja9	1095	38	Europe	Europe	NNP
cord-006702-ekf6mja9	1095	39	.	.	.
cord-006702-ekf6mja9	1096	1	FP	FP	NNP
cord-006702-ekf6mja9	1096	2	-	-	HYPH
cord-006702-ekf6mja9	1096	3	S29	S29	NNP
cord-006702-ekf6mja9	1096	4	-	-	HYPH
cord-006702-ekf6mja9	1096	5	1	1	CD
cord-006702-ekf6mja9	1097	1	The	the	DT
cord-006702-ekf6mja9	1097	2	Global	Global	NNP
cord-006702-ekf6mja9	1097	3	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	1097	4	Nephrology	Nephrology	NNP
cord-006702-ekf6mja9	1097	5	Workforce	Workforce	NNP
cord-006702-ekf6mja9	1097	6	:	:	:
cord-006702-ekf6mja9	1098	1	A	a	DT
cord-006702-ekf6mja9	1098	2	Survey	Survey	NNP
cord-006702-ekf6mja9	1098	3	of	of	IN
cord-006702-ekf6mja9	1098	4	the	the	DT
cord-006702-ekf6mja9	1098	5	International	International	NNP
cord-006702-ekf6mja9	1098	6	Pediatric	Pediatric	NNP
cord-006702-ekf6mja9	1098	7	Nephrology	Nephrology	NNP
cord-006702-ekf6mja9	1098	8	Association	Association	NNP
cord-006702-ekf6mja9	1098	9	D.	D.	NNP
cord-006702-ekf6mja9	1098	10	Glenn	Glenn	NNP
cord-006702-ekf6mja9	1098	11	(	(	-LRB-
cord-006702-ekf6mja9	1098	12	1	1	CD
cord-006702-ekf6mja9	1098	13	)	)	-RRB-
cord-006702-ekf6mja9	1098	14	,	,	,
cord-006702-ekf6mja9	1098	15	S.	S.	NNP
cord-006702-ekf6mja9	1098	16	Ocegueda	Ocegueda	NNP
cord-006702-ekf6mja9	1098	17	(	(	-LRB-
cord-006702-ekf6mja9	1098	18	1	1	CD
cord-006702-ekf6mja9	1098	19	)	)	-RRB-
cord-006702-ekf6mja9	1098	20	,	,	,
cord-006702-ekf6mja9	1098	21	M.	M.	NNP
cord-006702-ekf6mja9	1098	22	Nazareth	Nazareth	NNP
cord-006702-ekf6mja9	1098	23	(	(	-LRB-
cord-006702-ekf6mja9	1098	24	1	1	CD
cord-006702-ekf6mja9	1098	25	)	)	-RRB-
cord-006702-ekf6mja9	1098	26	,	,	,
cord-006702-ekf6mja9	1098	27	Y.	Y.	NNP
cord-006702-ekf6mja9	1098	28	Zhong	Zhong	NNP
cord-006702-ekf6mja9	1098	29	(	(	-LRB-
cord-006702-ekf6mja9	1098	30	1	1	CD
cord-006702-ekf6mja9	1098	31	)	)	-RRB-
cord-006702-ekf6mja9	1098	32	,	,	,
cord-006702-ekf6mja9	1098	33	A.	A.	NNP
cord-006702-ekf6mja9	1098	34	Weinstein	Weinstein	NNP
cord-006702-ekf6mja9	1098	35	(	(	-LRB-
cord-006702-ekf6mja9	1098	36	2	2	CD
cord-006702-ekf6mja9	1098	37	)	)	-RRB-
cord-006702-ekf6mja9	1098	38	,	,	,
cord-006702-ekf6mja9	1098	39	W.	W.	NNP
cord-006702-ekf6mja9	1098	40	Primack	Primack	NNP
cord-006702-ekf6mja9	1098	41	(	(	-LRB-
cord-006702-ekf6mja9	1098	42	1	1	CD
cord-006702-ekf6mja9	1098	43	)	)	-RRB-
cord-006702-ekf6mja9	1098	44	,	,	,
cord-006702-ekf6mja9	1098	45	P.	P.	NNP
cord-006702-ekf6mja9	1098	46	Cochat	Cochat	NNP
cord-006702-ekf6mja9	1098	47	(	(	-LRB-
cord-006702-ekf6mja9	1098	48	3	3	CD
cord-006702-ekf6mja9	1098	49	)	)	-RRB-
cord-006702-ekf6mja9	1098	50	,	,	,
cord-006702-ekf6mja9	1098	51	M.	M.	NNP
cord-006702-ekf6mja9	1098	52	Ferris	Ferris	NNP
cord-006702-ekf6mja9	1098	53	(	(	-LRB-
cord-006702-ekf6mja9	1098	54	1	1	CD
cord-006702-ekf6mja9	1098	55	)	)	-RRB-
cord-006702-ekf6mja9	1098	56	(	(	-LRB-
cord-006702-ekf6mja9	1098	57	1	1	CD
cord-006702-ekf6mja9	1098	58	)	)	-RRB-
cord-006702-ekf6mja9	1098	59	Univeristy	Univeristy	NNP
cord-006702-ekf6mja9	1098	60	of	of	IN
cord-006702-ekf6mja9	1098	61	North	North	NNP
cord-006702-ekf6mja9	1098	62	Carolina	Carolina	NNP
cord-006702-ekf6mja9	1098	63	at	at	IN
cord-006702-ekf6mja9	1098	64	Chapel	Chapel	NNP
cord-006702-ekf6mja9	1098	65	Hill	Hill	NNP
cord-006702-ekf6mja9	1098	66	,	,	,
cord-006702-ekf6mja9	1098	67	Chapel	Chapel	NNP
cord-006702-ekf6mja9	1098	68	Hill	Hill	NNP
cord-006702-ekf6mja9	1098	69	,	,	,
cord-006702-ekf6mja9	1098	70	United	United	NNP
cord-006702-ekf6mja9	1098	71	States	States	NNP
cord-006702-ekf6mja9	1098	72	;	;	:
cord-006702-ekf6mja9	1098	73	(	(	-LRB-
cord-006702-ekf6mja9	1098	74	2	2	LS
cord-006702-ekf6mja9	1098	75	)	)	-RRB-
cord-006702-ekf6mja9	1098	76	Dartmouth	Dartmouth	NNP
cord-006702-ekf6mja9	1098	77	Hitchcock	Hitchcock	NNP
cord-006702-ekf6mja9	1098	78	Medical	Medical	NNP
cord-006702-ekf6mja9	1098	79	Center	Center	NNP
cord-006702-ekf6mja9	1098	80	,	,	,
cord-006702-ekf6mja9	1098	81	Lebanon	Lebanon	NNP
cord-006702-ekf6mja9	1098	82	,	,	,
cord-006702-ekf6mja9	1098	83	United	United	NNP
cord-006702-ekf6mja9	1098	84	States	States	NNP
cord-006702-ekf6mja9	1098	85	;	;	:
cord-006702-ekf6mja9	1098	86	(	(	-LRB-
cord-006702-ekf6mja9	1098	87	3	3	LS
cord-006702-ekf6mja9	1098	88	)	)	-RRB-
cord-006702-ekf6mja9	1099	1	Hôpital	Hôpital	NNP
cord-006702-ekf6mja9	1099	2	Femme	Femme	NNP
cord-006702-ekf6mja9	1099	3	Mère	Mère	NNP
cord-006702-ekf6mja9	1099	4	Enfant	Enfant	NNP
cord-006702-ekf6mja9	1099	5	&	&	CC
cord-006702-ekf6mja9	1099	6	Université	Université	NNP
cord-006702-ekf6mja9	1099	7	Claude	Claude	NNP
cord-006702-ekf6mja9	1099	8	-	-	HYPH
cord-006702-ekf6mja9	1099	9	Bernard	Bernard	NNP
cord-006702-ekf6mja9	1099	10	,	,	,
cord-006702-ekf6mja9	1099	11	Lyon	Lyon	NNP
cord-006702-ekf6mja9	1099	12	,	,	,
cord-006702-ekf6mja9	1099	13	France	France	NNP
cord-006702-ekf6mja9	1099	14	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1099	15	:	:	:
cord-006702-ekf6mja9	1100	1	The	the	DT
cord-006702-ekf6mja9	1100	2	global	global	JJ
cord-006702-ekf6mja9	1100	3	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1100	4	nephrology	nephrology	NN
cord-006702-ekf6mja9	1100	5	workforce	workforce	NN
cord-006702-ekf6mja9	1100	6	is	be	VBZ
cord-006702-ekf6mja9	1100	7	poorly	poorly	RB
cord-006702-ekf6mja9	1100	8	characterized	characterize	VBN
cord-006702-ekf6mja9	1100	9	.	.	.
cord-006702-ekf6mja9	1101	1	The	the	DT
cord-006702-ekf6mja9	1101	2	objectives	objective	NNS
cord-006702-ekf6mja9	1101	3	of	of	IN
cord-006702-ekf6mja9	1101	4	our	-PRON-	PRP$
cord-006702-ekf6mja9	1101	5	study	study	NN
cord-006702-ekf6mja9	1101	6	were	be	VBD
cord-006702-ekf6mja9	1101	7	to	to	TO
cord-006702-ekf6mja9	1101	8	characterize	characterize	VB
cord-006702-ekf6mja9	1101	9	the	the	DT
cord-006702-ekf6mja9	1101	10	global	global	JJ
cord-006702-ekf6mja9	1101	11	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1101	12	nephrology	nephrology	NN
cord-006702-ekf6mja9	1101	13	workforce	workforce	NN
cord-006702-ekf6mja9	1101	14	and	and	CC
cord-006702-ekf6mja9	1101	15	training	training	NN
cord-006702-ekf6mja9	1101	16	environments	environment	NNS
cord-006702-ekf6mja9	1101	17	,	,	,
cord-006702-ekf6mja9	1101	18	assess	assess	VB
cord-006702-ekf6mja9	1101	19	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1101	20	nephrologists	nephrologist	NNS
cord-006702-ekf6mja9	1101	21	'	'	POS
cord-006702-ekf6mja9	1101	22	perceptions	perception	NNS
cord-006702-ekf6mja9	1101	23	of	of	IN
cord-006702-ekf6mja9	1101	24	the	the	DT
cord-006702-ekf6mja9	1101	25	adequacy	adequacy	NN
cord-006702-ekf6mja9	1101	26	of	of	IN
cord-006702-ekf6mja9	1101	27	this	this	DT
cord-006702-ekf6mja9	1101	28	workforce	workforce	NN
cord-006702-ekf6mja9	1101	29	,	,	,
cord-006702-ekf6mja9	1101	30	and	and	CC
cord-006702-ekf6mja9	1101	31	understand	understand	VB
cord-006702-ekf6mja9	1101	32	regional	regional	JJ
cord-006702-ekf6mja9	1101	33	challenges	challenge	NNS
cord-006702-ekf6mja9	1101	34	to	to	IN
cord-006702-ekf6mja9	1101	35	fellow	fellow	JJ
cord-006702-ekf6mja9	1101	36	recruitment	recruitment	NN
cord-006702-ekf6mja9	1101	37	and	and	CC
cord-006702-ekf6mja9	1101	38	job	job	NN
cord-006702-ekf6mja9	1101	39	acquisition	acquisition	NN
cord-006702-ekf6mja9	1101	40	.	.	.
cord-006702-ekf6mja9	1102	1	Perceptions	perception	NNS
cord-006702-ekf6mja9	1102	2	regarding	regard	VBG
cord-006702-ekf6mja9	1102	3	optimal	optimal	JJ
cord-006702-ekf6mja9	1102	4	length	length	NN
cord-006702-ekf6mja9	1102	5	of	of	IN
cord-006702-ekf6mja9	1102	6	training	training	NN
cord-006702-ekf6mja9	1102	7	and	and	CC
cord-006702-ekf6mja9	1102	8	research	research	NN
cord-006702-ekf6mja9	1102	9	requirements	requirement	NNS
cord-006702-ekf6mja9	1102	10	were	be	VBD
cord-006702-ekf6mja9	1102	11	also	also	RB
cord-006702-ekf6mja9	1102	12	queried	query	VBN
cord-006702-ekf6mja9	1102	13	.	.	.
cord-006702-ekf6mja9	1103	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1103	2	:	:	:
cord-006702-ekf6mja9	1104	1	Globally	globally	RB
cord-006702-ekf6mja9	1104	2	,	,	,
cord-006702-ekf6mja9	1104	3	there	there	EX
cord-006702-ekf6mja9	1104	4	is	be	VBZ
cord-006702-ekf6mja9	1104	5	a	a	DT
cord-006702-ekf6mja9	1104	6	high	high	JJ
cord-006702-ekf6mja9	1104	7	level	level	NN
cord-006702-ekf6mja9	1104	8	of	of	IN
cord-006702-ekf6mja9	1104	9	perceived	perceive	VBN
cord-006702-ekf6mja9	1104	10	inadequacy	inadequacy	NN
cord-006702-ekf6mja9	1104	11	in	in	IN
cord-006702-ekf6mja9	1104	12	the	the	DT
cord-006702-ekf6mja9	1104	13	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1104	14	nephrology	nephrology	NN
cord-006702-ekf6mja9	1104	15	workforce	workforce	NN
cord-006702-ekf6mja9	1104	16	.	.	.
cord-006702-ekf6mja9	1105	1	Regional	regional	JJ
cord-006702-ekf6mja9	1105	2	variability	variability	NN
cord-006702-ekf6mja9	1105	3	exists	exist	VBZ
cord-006702-ekf6mja9	1105	4	in	in	IN
cord-006702-ekf6mja9	1105	5	perceived	perceive	VBN
cord-006702-ekf6mja9	1105	6	workforce	workforce	NN
cord-006702-ekf6mja9	1105	7	adequacy	adequacy	NN
cord-006702-ekf6mja9	1105	8	,	,	,
cord-006702-ekf6mja9	1105	9	ease	ease	NN
cord-006702-ekf6mja9	1105	10	of	of	IN
cord-006702-ekf6mja9	1105	11	recruitment	recruitment	NN
cord-006702-ekf6mja9	1105	12	,	,	,
cord-006702-ekf6mja9	1105	13	and	and	CC
cord-006702-ekf6mja9	1105	14	job	job	NN
cord-006702-ekf6mja9	1105	15	acquisition	acquisition	NN
cord-006702-ekf6mja9	1105	16	.	.	.
cord-006702-ekf6mja9	1106	1	Interventions	intervention	NNS
cord-006702-ekf6mja9	1106	2	to	to	TO
cord-006702-ekf6mja9	1106	3	improve	improve	VB
cord-006702-ekf6mja9	1106	4	recruitment	recruitment	NN
cord-006702-ekf6mja9	1106	5	should	should	MD
cord-006702-ekf6mja9	1106	6	be	be	VB
cord-006702-ekf6mja9	1106	7	targeted	target	VBN
cord-006702-ekf6mja9	1106	8	to	to	IN
cord-006702-ekf6mja9	1106	9	specific	specific	JJ
cord-006702-ekf6mja9	1106	10	regional	regional	JJ
cord-006702-ekf6mja9	1106	11	barriers	barrier	NNS
cord-006702-ekf6mja9	1106	12	.	.	.
cord-006702-ekf6mja9	1107	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1107	2	:	:	:
cord-006702-ekf6mja9	1107	3	To	to	TO
cord-006702-ekf6mja9	1107	4	evaluate	evaluate	VB
cord-006702-ekf6mja9	1107	5	an	an	DT
cord-006702-ekf6mja9	1107	6	interinstitutional	interinstitutional	JJ
cord-006702-ekf6mja9	1107	7	cooperation	cooperation	NN
cord-006702-ekf6mja9	1107	8	program	program	NN
cord-006702-ekf6mja9	1107	9	between	between	IN
cord-006702-ekf6mja9	1107	10	an	an	DT
cord-006702-ekf6mja9	1107	11	experienced	experienced	JJ
cord-006702-ekf6mja9	1107	12	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1107	13	transplantation	transplantation	NN
cord-006702-ekf6mja9	1107	14	center	center	NN
cord-006702-ekf6mja9	1107	15	and	and	CC
cord-006702-ekf6mja9	1107	16	a	a	DT
cord-006702-ekf6mja9	1107	17	developing	develop	VBG
cord-006702-ekf6mja9	1107	18	center	center	NN
cord-006702-ekf6mja9	1107	19	in	in	IN
cord-006702-ekf6mja9	1107	20	other	other	JJ
cord-006702-ekf6mja9	1107	21	state	state	NN
cord-006702-ekf6mja9	1107	22	,	,	,
cord-006702-ekf6mja9	1107	23	600	600	CD
cord-006702-ekf6mja9	1107	24	km	km	NNS
cord-006702-ekf6mja9	1107	25	apart	apart	RB
cord-006702-ekf6mja9	1107	26	,	,	,
cord-006702-ekf6mja9	1107	27	and	and	CC
cord-006702-ekf6mja9	1107	28	the	the	DT
cord-006702-ekf6mja9	1107	29	count	count	NN
cord-006702-ekf6mja9	1107	30	of	of	IN
cord-006702-ekf6mja9	1107	31	kidney	kidney	NN
cord-006702-ekf6mja9	1107	32	transplantation	transplantation	NN
cord-006702-ekf6mja9	1107	33	surgeries	surgery	NNS
cord-006702-ekf6mja9	1107	34	performed	perform	VBN
cord-006702-ekf6mja9	1107	35	during	during	IN
cord-006702-ekf6mja9	1107	36	the	the	DT
cord-006702-ekf6mja9	1107	37	3-year	3-year	JJ
cord-006702-ekf6mja9	1107	38	duration	duration	NN
cord-006702-ekf6mja9	1107	39	of	of	IN
cord-006702-ekf6mja9	1107	40	the	the	DT
cord-006702-ekf6mja9	1107	41	cooperation	cooperation	NN
cord-006702-ekf6mja9	1107	42	.	.	.
cord-006702-ekf6mja9	1108	1	Methods	method	NNS
cord-006702-ekf6mja9	1108	2	:	:	:
cord-006702-ekf6mja9	1109	1	The	the	DT
cord-006702-ekf6mja9	1109	2	cooperation	cooperation	NN
cord-006702-ekf6mja9	1109	3	consisted	consist	VBD
cord-006702-ekf6mja9	1109	4	of	of	IN
cord-006702-ekf6mja9	1109	5	short	short	JJ
cord-006702-ekf6mja9	1109	6	periods	period	NNS
cord-006702-ekf6mja9	1109	7	of	of	IN
cord-006702-ekf6mja9	1109	8	fellowship	fellowship	NN
cord-006702-ekf6mja9	1109	9	(	(	-LRB-
cord-006702-ekf6mja9	1109	10	max	max	NNP
cord-006702-ekf6mja9	1109	11	1	1	CD
cord-006702-ekf6mja9	1109	12	month	month	NN
cord-006702-ekf6mja9	1109	13	)	)	-RRB-
cord-006702-ekf6mja9	1109	14	of	of	IN
cord-006702-ekf6mja9	1109	15	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1109	16	nephrology	nephrology	NN
cord-006702-ekf6mja9	1109	17	residents	resident	NNS
cord-006702-ekf6mja9	1109	18	,	,	,
cord-006702-ekf6mja9	1109	19	nurse	nurse	NN
cord-006702-ekf6mja9	1109	20	and	and	CC
cord-006702-ekf6mja9	1109	21	2	2	CD
cord-006702-ekf6mja9	1109	22	physicians	physician	NNS
cord-006702-ekf6mja9	1109	23	(	(	-LRB-
cord-006702-ekf6mja9	1109	24	one	one	CD
cord-006702-ekf6mja9	1109	25	pednephrologist	pednephrologist	NN
cord-006702-ekf6mja9	1109	26	and	and	CC
cord-006702-ekf6mja9	1109	27	1	1	CD
cord-006702-ekf6mja9	1109	28	surgeon	surgeon	NN
cord-006702-ekf6mja9	1109	29	)	)	-RRB-
cord-006702-ekf6mja9	1109	30	,	,	,
cord-006702-ekf6mja9	1109	31	along	along	IN
cord-006702-ekf6mja9	1109	32	a	a	DT
cord-006702-ekf6mja9	1109	33	3-year	3-year	CD
cord-006702-ekf6mja9	1109	34	period	period	NN
cord-006702-ekf6mja9	1109	35	,	,	,
cord-006702-ekf6mja9	1109	36	as	as	RB
cord-006702-ekf6mja9	1109	37	well	well	RB
cord-006702-ekf6mja9	1109	38	as	as	IN
cord-006702-ekf6mja9	1109	39	weekly	weekly	JJ
cord-006702-ekf6mja9	1109	40	teleconferences	teleconference	NNS
cord-006702-ekf6mja9	1109	41	for	for	IN
cord-006702-ekf6mja9	1109	42	case	case	NN
cord-006702-ekf6mja9	1109	43	discussions	discussion	NNS
cord-006702-ekf6mja9	1109	44	once	once	RB
cord-006702-ekf6mja9	1109	45	a	a	DT
cord-006702-ekf6mja9	1109	46	week	week	NN
cord-006702-ekf6mja9	1109	47	.	.	.
cord-006702-ekf6mja9	1110	1	The	the	DT
cord-006702-ekf6mja9	1110	2	yearly	yearly	JJ
cord-006702-ekf6mja9	1110	3	count	count	NN
cord-006702-ekf6mja9	1110	4	of	of	IN
cord-006702-ekf6mja9	1110	5	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1110	6	kidney	kidney	NN
cord-006702-ekf6mja9	1110	7	transplants	transplant	NNS
cord-006702-ekf6mja9	1110	8	(	(	-LRB-
cord-006702-ekf6mja9	1110	9	p	p	NN
cord-006702-ekf6mja9	1110	10	-	-	HYPH
cord-006702-ekf6mja9	1110	11	KT	KT	NNP
cord-006702-ekf6mja9	1110	12	)	)	-RRB-
cord-006702-ekf6mja9	1110	13	in	in	IN
cord-006702-ekf6mja9	1110	14	the	the	DT
cord-006702-ekf6mja9	1110	15	developing	develop	VBG
cord-006702-ekf6mja9	1110	16	center	center	NN
cord-006702-ekf6mja9	1110	17	along	along	IN
cord-006702-ekf6mja9	1110	18	the	the	DT
cord-006702-ekf6mja9	1110	19	period	period	NN
cord-006702-ekf6mja9	1110	20	was	be	VBD
cord-006702-ekf6mja9	1110	21	compared	compare	VBN
cord-006702-ekf6mja9	1110	22	to	to	IN
cord-006702-ekf6mja9	1110	23	the	the	DT
cord-006702-ekf6mja9	1110	24	national	national	JJ
cord-006702-ekf6mja9	1110	25	mean	mean	NN
cord-006702-ekf6mja9	1110	26	as	as	RB
cord-006702-ekf6mja9	1110	27	well	well	RB
cord-006702-ekf6mja9	1110	28	to	to	IN
cord-006702-ekf6mja9	1110	29	the	the	DT
cord-006702-ekf6mja9	1110	30	state	state	NN
cord-006702-ekf6mja9	1110	31	's	's	POS
cord-006702-ekf6mja9	1110	32	mean	mean	NN
cord-006702-ekf6mja9	1110	33	.	.	.
cord-006702-ekf6mja9	1111	1	In	in	IN
cord-006702-ekf6mja9	1111	2	total	total	JJ
cord-006702-ekf6mja9	1111	3	,	,	,
cord-006702-ekf6mja9	1111	4	209	209	CD
cord-006702-ekf6mja9	1111	5	samples	sample	NNS
cord-006702-ekf6mja9	1111	6	were	be	VBD
cord-006702-ekf6mja9	1111	7	taken	take	VBN
cord-006702-ekf6mja9	1111	8	from	from	IN
cord-006702-ekf6mja9	1111	9	11	11	CD
cord-006702-ekf6mja9	1111	10	patients	patient	NNS
cord-006702-ekf6mja9	1111	11	before	before	IN
cord-006702-ekf6mja9	1111	12	the	the	DT
cord-006702-ekf6mja9	1111	13	eculizumab	eculizumab	NNP
cord-006702-ekf6mja9	1111	14	infusion	infusion	NN
cord-006702-ekf6mja9	1111	15	in	in	IN
cord-006702-ekf6mja9	1111	16	the	the	DT
cord-006702-ekf6mja9	1111	17	induction	induction	NN
cord-006702-ekf6mja9	1111	18	(	(	-LRB-
cord-006702-ekf6mja9	1111	19	weekly	weekly	NNP
cord-006702-ekf6mja9	1111	20	)	)	-RRB-
cord-006702-ekf6mja9	1111	21	,	,	,
cord-006702-ekf6mja9	1111	22	maintenance	maintenance	NN
cord-006702-ekf6mja9	1111	23	(	(	-LRB-
cord-006702-ekf6mja9	1111	24	2-weekly	2-weekly	CD
cord-006702-ekf6mja9	1111	25	)	)	-RRB-
cord-006702-ekf6mja9	1111	26	and	and	CC
cord-006702-ekf6mja9	1111	27	tapering	taper	VBG
cord-006702-ekf6mja9	1111	28	(	(	-LRB-
cord-006702-ekf6mja9	1111	29	every	every	DT
cord-006702-ekf6mja9	1111	30	3	3	CD
cord-006702-ekf6mja9	1111	31	,	,	,
cord-006702-ekf6mja9	1111	32	4	4	CD
cord-006702-ekf6mja9	1111	33	,	,	,
cord-006702-ekf6mja9	1111	34	and	and	CC
cord-006702-ekf6mja9	1111	35	5	5	CD
cord-006702-ekf6mja9	1111	36	weeks	week	NNS
cord-006702-ekf6mja9	1111	37	)	)	-RRB-
cord-006702-ekf6mja9	1111	38	phases	phase	NNS
cord-006702-ekf6mja9	1111	39	of	of	IN
cord-006702-ekf6mja9	1111	40	therapy	therapy	NN
cord-006702-ekf6mja9	1111	41	.	.	.
cord-006702-ekf6mja9	1112	1	Results	result	NNS
cord-006702-ekf6mja9	1112	2	:	:	:
cord-006702-ekf6mja9	1113	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	1113	2	newly	newly	RB
cord-006702-ekf6mja9	1113	3	-	-	HYPH
cord-006702-ekf6mja9	1113	4	developed	develop	VBN
cord-006702-ekf6mja9	1113	5	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1113	6	assay	assay	NN
cord-006702-ekf6mja9	1113	7	had	have	VBD
cord-006702-ekf6mja9	1113	8	variation	variation	NN
cord-006702-ekf6mja9	1113	9	coefficients	coefficient	NNS
cord-006702-ekf6mja9	1113	10	of	of	IN
cord-006702-ekf6mja9	1113	11	2.9	2.9	CD
cord-006702-ekf6mja9	1113	12	%	%	NN
cord-006702-ekf6mja9	1113	13	(	(	-LRB-
cord-006702-ekf6mja9	1113	14	intra	intra	JJ
cord-006702-ekf6mja9	1113	15	-	-	JJ
cord-006702-ekf6mja9	1113	16	assay	assay	NN
cord-006702-ekf6mja9	1113	17	,	,	,
cord-006702-ekf6mja9	1113	18	352	352	CD
cord-006702-ekf6mja9	1113	19	μg	μg	NN
cord-006702-ekf6mja9	1113	20	/	/	SYM
cord-006702-ekf6mja9	1113	21	mL	mL	NNP
cord-006702-ekf6mja9	1113	22	)	)	-RRB-
cord-006702-ekf6mja9	1113	23	and	and	CC
cord-006702-ekf6mja9	1113	24	5.2	5.2	CD
cord-006702-ekf6mja9	1113	25	%	%	NN
cord-006702-ekf6mja9	1113	26	(	(	-LRB-
cord-006702-ekf6mja9	1113	27	inter	inter	JJ
cord-006702-ekf6mja9	1113	28	-	-	JJ
cord-006702-ekf6mja9	1113	29	assay	assay	NN
cord-006702-ekf6mja9	1113	30	,	,	,
cord-006702-ekf6mja9	1113	31	328	328	CD
cord-006702-ekf6mja9	1113	32	μg	μg	NN
cord-006702-ekf6mja9	1113	33	/	/	SYM
cord-006702-ekf6mja9	1113	34	mL	mL	NNP
cord-006702-ekf6mja9	1113	35	)	)	-RRB-
cord-006702-ekf6mja9	1113	36	and	and	CC
cord-006702-ekf6mja9	1113	37	detection	detection	NN
cord-006702-ekf6mja9	1113	38	limit	limit	NN
cord-006702-ekf6mja9	1113	39	of	of	IN
cord-006702-ekf6mja9	1113	40	8	8	CD
cord-006702-ekf6mja9	1113	41	μg/	μg/	NN
cord-006702-ekf6mja9	1114	1	mL.	mL.	NNP
cord-006702-ekf6mja9	1114	2	The	the	DT
cord-006702-ekf6mja9	1114	3	samples	sample	NNS
cord-006702-ekf6mja9	1114	4	with	with	IN
cord-006702-ekf6mja9	1114	5	>	>	XX
cord-006702-ekf6mja9	1114	6	50	50	CD
cord-006702-ekf6mja9	1114	7	μg	μg	NNS
cord-006702-ekf6mja9	1114	8	/	/	SYM
cord-006702-ekf6mja9	1114	9	mL	mL	NNP
cord-006702-ekf6mja9	1114	10	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	1114	11	<	<	NNP
cord-006702-ekf6mja9	1114	12	6	6	CD
cord-006702-ekf6mja9	1114	13	%	%	NN
cord-006702-ekf6mja9	1114	14	of	of	IN
cord-006702-ekf6mja9	1114	15	complement	complement	JJ
cord-006702-ekf6mja9	1114	16	activity	activity	NN
cord-006702-ekf6mja9	1114	17	in	in	IN
cord-006702-ekf6mja9	1114	18	classical	classical	JJ
cord-006702-ekf6mja9	1114	19	and	and	CC
cord-006702-ekf6mja9	1114	20	alternative	alternative	JJ
cord-006702-ekf6mja9	1114	21	complement	complement	NN
cord-006702-ekf6mja9	1114	22	pathways	pathway	NNS
cord-006702-ekf6mja9	1114	23	.	.	.
cord-006702-ekf6mja9	1115	1	The	the	DT
cord-006702-ekf6mja9	1115	2	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1115	3	levels	level	NNS
cord-006702-ekf6mja9	1115	4	had	have	VBD
cord-006702-ekf6mja9	1115	5	ranges	range	NNS
cord-006702-ekf6mja9	1115	6	of	of	IN
cord-006702-ekf6mja9	1115	7	36	36	CD
cord-006702-ekf6mja9	1115	8	-	-	SYM
cord-006702-ekf6mja9	1115	9	459	459	CD
cord-006702-ekf6mja9	1115	10	μg	μg	NNP
cord-006702-ekf6mja9	1115	11	/	/	SYM
cord-006702-ekf6mja9	1115	12	mL	ml	NN
cord-006702-ekf6mja9	1115	13	and	and	CC
cord-006702-ekf6mja9	1115	14	40	40	CD
cord-006702-ekf6mja9	1115	15	-	-	SYM
cord-006702-ekf6mja9	1115	16	772	772	CD
cord-006702-ekf6mja9	1115	17	μg	μg	NN
cord-006702-ekf6mja9	1115	18	/	/	SYM
cord-006702-ekf6mja9	1115	19	mL	ml	NN
cord-006702-ekf6mja9	1115	20	during	during	IN
cord-006702-ekf6mja9	1115	21	induction	induction	NN
cord-006702-ekf6mja9	1115	22	and	and	CC
cord-006702-ekf6mja9	1115	23	maintenance	maintenance	NN
cord-006702-ekf6mja9	1115	24	phases	phase	NNS
cord-006702-ekf6mja9	1115	25	,	,	,
cord-006702-ekf6mja9	1115	26	respectively	respectively	RB
cord-006702-ekf6mja9	1115	27	,	,	,
cord-006702-ekf6mja9	1115	28	with	with	IN
cord-006702-ekf6mja9	1115	29	3	3	CD
cord-006702-ekf6mja9	1115	30	samples	sample	NNS
cord-006702-ekf6mja9	1115	31	from	from	IN
cord-006702-ekf6mja9	1115	32	2	2	CD
cord-006702-ekf6mja9	1115	33	patients	patient	NNS
cord-006702-ekf6mja9	1115	34	<	<	XX
cord-006702-ekf6mja9	1115	35	50	50	CD
cord-006702-ekf6mja9	1115	36	μg	μg	NNS
cord-006702-ekf6mja9	1115	37	/	/	SYM
cord-006702-ekf6mja9	1115	38	mL	ml	NN
cord-006702-ekf6mja9	1115	39	,	,	,
cord-006702-ekf6mja9	1115	40	required	require	VBN
cord-006702-ekf6mja9	1115	41	for	for	IN
cord-006702-ekf6mja9	1115	42	efficient	efficient	JJ
cord-006702-ekf6mja9	1115	43	complement	complement	NN
cord-006702-ekf6mja9	1115	44	inhibition	inhibition	NN
cord-006702-ekf6mja9	1115	45	.	.	.
cord-006702-ekf6mja9	1116	1	During	during	IN
cord-006702-ekf6mja9	1116	2	tapering	taper	VBG
cord-006702-ekf6mja9	1116	3	,	,	,
cord-006702-ekf6mja9	1116	4	ranges	range	NNS
cord-006702-ekf6mja9	1116	5	of	of	IN
cord-006702-ekf6mja9	1116	6	61	61	CD
cord-006702-ekf6mja9	1116	7	-	-	SYM
cord-006702-ekf6mja9	1116	8	367	367	CD
cord-006702-ekf6mja9	1116	9	μg	μg	NN
cord-006702-ekf6mja9	1116	10	/	/	SYM
cord-006702-ekf6mja9	1116	11	mL	ml	NN
cord-006702-ekf6mja9	1116	12	,	,	,
cord-006702-ekf6mja9	1116	13	11	11	CD
cord-006702-ekf6mja9	1116	14	-	-	SYM
cord-006702-ekf6mja9	1116	15	256	256	CD
cord-006702-ekf6mja9	1116	16	μg	μg	NN
cord-006702-ekf6mja9	1116	17	/	/	SYM
cord-006702-ekf6mja9	1116	18	mL	ml	NN
cord-006702-ekf6mja9	1116	19	and	and	CC
cord-006702-ekf6mja9	1116	20	13	13	CD
cord-006702-ekf6mja9	1116	21	-	-	SYM
cord-006702-ekf6mja9	1116	22	161	161	CD
cord-006702-ekf6mja9	1116	23	μg	μg	NNP
cord-006702-ekf6mja9	1116	24	/	/	SYM
cord-006702-ekf6mja9	1116	25	mL	mL	NNP
cord-006702-ekf6mja9	1116	26	were	be	VBD
cord-006702-ekf6mja9	1116	27	measured	measure	VBN
cord-006702-ekf6mja9	1116	28	at	at	IN
cord-006702-ekf6mja9	1116	29	3	3	CD
cord-006702-ekf6mja9	1116	30	,	,	,
cord-006702-ekf6mja9	1116	31	4	4	CD
cord-006702-ekf6mja9	1116	32	and	and	CC
cord-006702-ekf6mja9	1116	33	5	5	CD
cord-006702-ekf6mja9	1116	34	week	week	NN
cord-006702-ekf6mja9	1116	35	infusion	infusion	NN
cord-006702-ekf6mja9	1116	36	intervals	interval	NNS
cord-006702-ekf6mja9	1116	37	,	,	,
cord-006702-ekf6mja9	1116	38	respectively	respectively	RB
cord-006702-ekf6mja9	1116	39	.	.	.
cord-006702-ekf6mja9	1117	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1117	2	:	:	:
cord-006702-ekf6mja9	1118	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	1118	2	data	datum	NNS
cord-006702-ekf6mja9	1118	3	demonstrate	demonstrate	VBP
cord-006702-ekf6mja9	1118	4	large	large	JJ
cord-006702-ekf6mja9	1118	5	differences	difference	NNS
cord-006702-ekf6mja9	1118	6	in	in	IN
cord-006702-ekf6mja9	1118	7	attained	attain	VBN
cord-006702-ekf6mja9	1118	8	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1118	9	concentrations	concentration	NNS
cord-006702-ekf6mja9	1118	10	among	among	IN
cord-006702-ekf6mja9	1118	11	patients	patient	NNS
cord-006702-ekf6mja9	1118	12	at	at	IN
cord-006702-ekf6mja9	1118	13	all	all	DT
cord-006702-ekf6mja9	1118	14	treatment	treatment	NN
cord-006702-ekf6mja9	1118	15	stages	stage	NNS
cord-006702-ekf6mja9	1118	16	.	.	.
cord-006702-ekf6mja9	1119	1	In	in	IN
cord-006702-ekf6mja9	1119	2	induction	induction	NN
cord-006702-ekf6mja9	1119	3	and	and	CC
cord-006702-ekf6mja9	1119	4	maintenance	maintenance	NN
cord-006702-ekf6mja9	1119	5	,	,	,
cord-006702-ekf6mja9	1119	6	the	the	DT
cord-006702-ekf6mja9	1119	7	detected	detect	VBN
cord-006702-ekf6mja9	1119	8	concentrations	concentration	NNS
cord-006702-ekf6mja9	1119	9	were	be	VBD
cord-006702-ekf6mja9	1119	10	up	up	RB
cord-006702-ekf6mja9	1119	11	to	to	TO
cord-006702-ekf6mja9	1119	12	9	9	CD
cord-006702-ekf6mja9	1119	13	-	-	SYM
cord-006702-ekf6mja9	1119	14	15	15	CD
cord-006702-ekf6mja9	1119	15	fold	fold	VB
cord-006702-ekf6mja9	1119	16	higher	higher	RBR
cord-006702-ekf6mja9	1119	17	than	than	IN
cord-006702-ekf6mja9	1119	18	required	require	VBN
cord-006702-ekf6mja9	1119	19	for	for	IN
cord-006702-ekf6mja9	1119	20	efficient	efficient	JJ
cord-006702-ekf6mja9	1119	21	complement	complement	NN
cord-006702-ekf6mja9	1119	22	inhibition	inhibition	NN
cord-006702-ekf6mja9	1119	23	(	(	-LRB-
cord-006702-ekf6mja9	1119	24	50	50	CD
cord-006702-ekf6mja9	1119	25	μg	μg	NN
cord-006702-ekf6mja9	1119	26	/	/	SYM
cord-006702-ekf6mja9	1119	27	mL	mL	NNP
cord-006702-ekf6mja9	1119	28	)	)	-RRB-
cord-006702-ekf6mja9	1119	29	,	,	,
cord-006702-ekf6mja9	1119	30	although	although	IN
cord-006702-ekf6mja9	1119	31	3	3	CD
cord-006702-ekf6mja9	1119	32	samples	sample	NNS
cord-006702-ekf6mja9	1119	33	did	do	VBD
cord-006702-ekf6mja9	1119	34	not	not	RB
cord-006702-ekf6mja9	1119	35	reach	reach	VB
cord-006702-ekf6mja9	1119	36	this	this	DT
cord-006702-ekf6mja9	1119	37	target	target	NN
cord-006702-ekf6mja9	1119	38	value	value	NN
cord-006702-ekf6mja9	1119	39	.	.	.
cord-006702-ekf6mja9	1120	1	Thus	thus	RB
cord-006702-ekf6mja9	1120	2	,	,	,
cord-006702-ekf6mja9	1120	3	eculizumab	eculizumab	NNP
cord-006702-ekf6mja9	1120	4	therapy	therapy	NN
cord-006702-ekf6mja9	1120	5	should	should	MD
cord-006702-ekf6mja9	1120	6	be	be	VB
cord-006702-ekf6mja9	1120	7	adjusted	adjust	VBN
cord-006702-ekf6mja9	1120	8	to	to	TO
cord-006702-ekf6mja9	1120	9	meet	meet	VB
cord-006702-ekf6mja9	1120	10	the	the	DT
cord-006702-ekf6mja9	1120	11	needs	need	NNS
cord-006702-ekf6mja9	1120	12	of	of	IN
cord-006702-ekf6mja9	1120	13	individual	individual	JJ
cord-006702-ekf6mja9	1120	14	patients	patient	NNS
cord-006702-ekf6mja9	1120	15	and	and	CC
cord-006702-ekf6mja9	1120	16	monitoring	monitoring	NN
cord-006702-ekf6mja9	1120	17	of	of	IN
cord-006702-ekf6mja9	1120	18	eculizumab	eculizumab	NNP
cord-006702-ekf6mja9	1120	19	concentration	concentration	NN
cord-006702-ekf6mja9	1120	20	is	be	VBZ
cord-006702-ekf6mja9	1120	21	useful	useful	JJ
cord-006702-ekf6mja9	1120	22	to	to	TO
cord-006702-ekf6mja9	1120	23	guide	guide	VB
cord-006702-ekf6mja9	1120	24	the	the	DT
cord-006702-ekf6mja9	1120	25	treatment	treatment	NN
cord-006702-ekf6mja9	1120	26	schemes	scheme	NNS
cord-006702-ekf6mja9	1120	27	.	.	.
cord-006702-ekf6mja9	1121	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1121	2	have	have	VBP
cord-006702-ekf6mja9	1121	3	shown	show	VBN
cord-006702-ekf6mja9	1121	4	that	that	IN
cord-006702-ekf6mja9	1121	5	target	target	NN
cord-006702-ekf6mja9	1121	6	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1121	7	values	value	NNS
cord-006702-ekf6mja9	1121	8	(	(	-LRB-
cord-006702-ekf6mja9	1121	9	>	>	NFP
cord-006702-ekf6mja9	1121	10	50	50	CD
cord-006702-ekf6mja9	1121	11	μg	μg	NN
cord-006702-ekf6mja9	1121	12	/	/	SYM
cord-006702-ekf6mja9	1121	13	mL	mL	NNP
cord-006702-ekf6mja9	1121	14	)	)	-RRB-
cord-006702-ekf6mja9	1121	15	may	may	MD
cord-006702-ekf6mja9	1121	16	be	be	VB
cord-006702-ekf6mja9	1121	17	reached	reach	VBN
cord-006702-ekf6mja9	1121	18	with	with	IN
cord-006702-ekf6mja9	1121	19	extended	extended	JJ
cord-006702-ekf6mja9	1121	20	intervals	interval	NNS
cord-006702-ekf6mja9	1121	21	;	;	:
cord-006702-ekf6mja9	1121	22	extension	extension	NN
cord-006702-ekf6mja9	1121	23	of	of	IN
cord-006702-ekf6mja9	1121	24	intervals	interval	NNS
cord-006702-ekf6mja9	1121	25	for	for	IN
cord-006702-ekf6mja9	1121	26	these	these	DT
cord-006702-ekf6mja9	1121	27	patients	patient	NNS
cord-006702-ekf6mja9	1121	28	may	may	MD
cord-006702-ekf6mja9	1121	29	improve	improve	VB
cord-006702-ekf6mja9	1121	30	cost	cost	NN
cord-006702-ekf6mja9	1121	31	-	-	HYPH
cord-006702-ekf6mja9	1121	32	effectiveness	effectiveness	NN
cord-006702-ekf6mja9	1121	33	of	of	IN
cord-006702-ekf6mja9	1121	34	therapy	therapy	NN
cord-006702-ekf6mja9	1121	35	.	.	.
cord-006702-ekf6mja9	1122	1	Outcomes	outcome	NNS
cord-006702-ekf6mja9	1122	2	from	from	IN
cord-006702-ekf6mja9	1122	3	an	an	DT
cord-006702-ekf6mja9	1122	4	observational	observational	JJ
cord-006702-ekf6mja9	1122	5	clinical	clinical	JJ
cord-006702-ekf6mja9	1122	6	trial	trial	NN
cord-006702-ekf6mja9	1122	7	evaluating	evaluate	VBG
cord-006702-ekf6mja9	1122	8	the	the	DT
cord-006702-ekf6mja9	1122	9	long	long	JJ
cord-006702-ekf6mja9	1122	10	-	-	HYPH
cord-006702-ekf6mja9	1122	11	term	term	NN
cord-006702-ekf6mja9	1122	12	safety	safety	NN
cord-006702-ekf6mja9	1122	13	and	and	CC
cord-006702-ekf6mja9	1122	14	effectiveness	effectiveness	NN
cord-006702-ekf6mja9	1122	15	of	of	IN
cord-006702-ekf6mja9	1122	16	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1122	17	use	use	VBP
cord-006702-ekf6mja9	1122	18	in	in	IN
cord-006702-ekf6mja9	1122	19	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1122	20	patients	patient	NNS
cord-006702-ekf6mja9	1122	21	with	with	IN
cord-006702-ekf6mja9	1122	22	atypical	atypical	JJ
cord-006702-ekf6mja9	1122	23	haemolytic	haemolytic	JJ
cord-006702-ekf6mja9	1122	24	uraemic	uraemic	JJ
cord-006702-ekf6mja9	1122	25	syndrome	syndrome	NN
cord-006702-ekf6mja9	1122	26	(	(	-LRB-
cord-006702-ekf6mja9	1122	27	aHUS	ahus	NN
cord-006702-ekf6mja9	1122	28	)	)	-RRB-
cord-006702-ekf6mja9	1123	1	L.	L.	NNP
cord-006702-ekf6mja9	1123	2	Pape	Pape	NNP
cord-006702-ekf6mja9	1123	3	(	(	-LRB-
cord-006702-ekf6mja9	1123	4	1	1	CD
cord-006702-ekf6mja9	1123	5	)	)	-RRB-
cord-006702-ekf6mja9	1123	6	Objectives	objective	NNS
cord-006702-ekf6mja9	1123	7	:	:	:
cord-006702-ekf6mja9	1123	8	To	to	TO
cord-006702-ekf6mja9	1123	9	describe	describe	VB
cord-006702-ekf6mja9	1123	10	the	the	DT
cord-006702-ekf6mja9	1123	11	long	long	JJ
cord-006702-ekf6mja9	1123	12	-	-	HYPH
cord-006702-ekf6mja9	1123	13	term	term	NN
cord-006702-ekf6mja9	1123	14	outcomes	outcome	NNS
cord-006702-ekf6mja9	1123	15	of	of	IN
cord-006702-ekf6mja9	1123	16	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1123	17	patients	patient	NNS
cord-006702-ekf6mja9	1123	18	(	(	-LRB-
cord-006702-ekf6mja9	1123	19	pts	pt	NNS
cord-006702-ekf6mja9	1123	20	)	)	-RRB-
cord-006702-ekf6mja9	1123	21	with	with	IN
cord-006702-ekf6mja9	1123	22	atypical	atypical	JJ
cord-006702-ekf6mja9	1123	23	haemolytic	haemolytic	JJ
cord-006702-ekf6mja9	1123	24	uraemic	uraemic	JJ
cord-006702-ekf6mja9	1123	25	syndrome	syndrome	NN
cord-006702-ekf6mja9	1123	26	(	(	-LRB-
cord-006702-ekf6mja9	1123	27	aHUS	ahus	RB
cord-006702-ekf6mja9	1123	28	)	)	-RRB-
cord-006702-ekf6mja9	1123	29	treated	treat	VBN
cord-006702-ekf6mja9	1123	30	with	with	IN
cord-006702-ekf6mja9	1123	31	eculizumab	eculizumab	NNS
cord-006702-ekf6mja9	1123	32	(	(	-LRB-
cord-006702-ekf6mja9	1123	33	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1123	34	)	)	-RRB-
cord-006702-ekf6mja9	1123	35	.	.	.
cord-006702-ekf6mja9	1124	1	Methods	method	NNS
cord-006702-ekf6mja9	1124	2	:	:	:
cord-006702-ekf6mja9	1124	3	Pts	Pts	NNP
cord-006702-ekf6mja9	1124	4	with	with	IN
cord-006702-ekf6mja9	1124	5	aHUS	ahus	DT
cord-006702-ekf6mja9	1124	6	who	who	WP
cord-006702-ekf6mja9	1124	7	participated	participate	VBD
cord-006702-ekf6mja9	1124	8	in	in	IN
cord-006702-ekf6mja9	1124	9	a	a	DT
cord-006702-ekf6mja9	1124	10	previous	previous	JJ
cord-006702-ekf6mja9	1124	11	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1124	12	clinical	clinical	JJ
cord-006702-ekf6mja9	1124	13	study	study	NN
cord-006702-ekf6mja9	1124	14	were	be	VBD
cord-006702-ekf6mja9	1124	15	invited	invite	VBN
cord-006702-ekf6mja9	1124	16	to	to	TO
cord-006702-ekf6mja9	1124	17	continue	continue	VB
cord-006702-ekf6mja9	1124	18	to	to	TO
cord-006702-ekf6mja9	1124	19	be	be	VB
cord-006702-ekf6mja9	1124	20	monitored	monitor	VBN
cord-006702-ekf6mja9	1124	21	in	in	IN
cord-006702-ekf6mja9	1124	22	this	this	DT
cord-006702-ekf6mja9	1124	23	observational	observational	JJ
cord-006702-ekf6mja9	1124	24	,	,	,
cord-006702-ekf6mja9	1124	25	multicentre	multicentre	NNP
cord-006702-ekf6mja9	1124	26	,	,	,
cord-006702-ekf6mja9	1124	27	multinational	multinational	JJ
cord-006702-ekf6mja9	1124	28	long	long	JJ
cord-006702-ekf6mja9	1124	29	-	-	HYPH
cord-006702-ekf6mja9	1124	30	term	term	NN
cord-006702-ekf6mja9	1124	31	follow	follow	NN
cord-006702-ekf6mja9	1124	32	-	-	HYPH
cord-006702-ekf6mja9	1124	33	up	up	NN
cord-006702-ekf6mja9	1124	34	study	study	NN
cord-006702-ekf6mja9	1124	35	(	(	-LRB-
cord-006702-ekf6mja9	1124	36	NCT01522170	NCT01522170	NNP
cord-006702-ekf6mja9	1124	37	)	)	-RRB-
cord-006702-ekf6mja9	1124	38	.	.	.
cord-006702-ekf6mja9	1125	1	This	this	DT
cord-006702-ekf6mja9	1125	2	analysis	analysis	NN
cord-006702-ekf6mja9	1125	3	included	include	VBD
cord-006702-ekf6mja9	1125	4	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1125	5	pts	pts	NN
cord-006702-ekf6mja9	1125	6	(	(	-LRB-
cord-006702-ekf6mja9	1125	7	<	<	NNP
cord-006702-ekf6mja9	1125	8	18	18	CD
cord-006702-ekf6mja9	1125	9	years	year	NNS
cord-006702-ekf6mja9	1125	10	old	old	JJ
cord-006702-ekf6mja9	1125	11	at	at	IN
cord-006702-ekf6mja9	1125	12	first	first	JJ
cord-006702-ekf6mja9	1125	13	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1125	14	dose	dose	NN
cord-006702-ekf6mja9	1125	15	)	)	-RRB-
cord-006702-ekf6mja9	1125	16	who	who	WP
cord-006702-ekf6mja9	1125	17	enrolled	enrol	VBD
cord-006702-ekf6mja9	1125	18	,	,	,
cord-006702-ekf6mja9	1125	19	including	include	VBG
cord-006702-ekf6mja9	1125	20	pts	pt	NNS
cord-006702-ekf6mja9	1125	21	treated	treat	VBN
cord-006702-ekf6mja9	1125	22	outside	outside	RB
cord-006702-ekf6mja9	1125	23	of	of	IN
cord-006702-ekf6mja9	1125	24	the	the	DT
cord-006702-ekf6mja9	1125	25	recommended	recommend	VBN
cord-006702-ekf6mja9	1125	26	regimen	regimen	NN
cord-006702-ekf6mja9	1125	27	.	.	.
cord-006702-ekf6mja9	1126	1	Change	change	VB
cord-006702-ekf6mja9	1126	2	in	in	IN
cord-006702-ekf6mja9	1126	3	renal	renal	JJ
cord-006702-ekf6mja9	1126	4	function	function	NN
cord-006702-ekf6mja9	1126	5	and	and	CC
cord-006702-ekf6mja9	1126	6	targeted	target	VBD
cord-006702-ekf6mja9	1126	7	serious	serious	JJ
cord-006702-ekf6mja9	1126	8	adverse	adverse	JJ
cord-006702-ekf6mja9	1126	9	events	event	NNS
cord-006702-ekf6mja9	1126	10	(	(	-LRB-
cord-006702-ekf6mja9	1126	11	TSAEs	tsae	NNS
cord-006702-ekf6mja9	1126	12	:	:	:
cord-006702-ekf6mja9	1126	13	serious	serious	JJ
cord-006702-ekf6mja9	1126	14	infections	infection	NNS
cord-006702-ekf6mja9	1126	15	,	,	,
cord-006702-ekf6mja9	1126	16	meningococcal	meningococcal	JJ
cord-006702-ekf6mja9	1126	17	infection	infection	NN
cord-006702-ekf6mja9	1126	18	,	,	,
cord-006702-ekf6mja9	1126	19	sepsis	sepsis	NN
cord-006702-ekf6mja9	1126	20	,	,	,
cord-006702-ekf6mja9	1126	21	leukopenia	leukopenia	NN
cord-006702-ekf6mja9	1126	22	,	,	,
cord-006702-ekf6mja9	1126	23	infusion	infusion	NN
cord-006702-ekf6mja9	1126	24	reactions	reaction	NNS
cord-006702-ekf6mja9	1126	25	,	,	,
cord-006702-ekf6mja9	1126	26	renal	renal	JJ
cord-006702-ekf6mja9	1126	27	or	or	CC
cord-006702-ekf6mja9	1126	28	hepatic	hepatic	JJ
cord-006702-ekf6mja9	1126	29	impairment	impairment	NN
cord-006702-ekf6mja9	1126	30	and	and	CC
cord-006702-ekf6mja9	1126	31	malignancy	malignancy	NN
cord-006702-ekf6mja9	1126	32	)	)	-RRB-
cord-006702-ekf6mja9	1126	33	were	be	VBD
cord-006702-ekf6mja9	1126	34	assessed	assess	VBN
cord-006702-ekf6mja9	1126	35	.	.	.
cord-006702-ekf6mja9	1127	1	Results	result	NNS
cord-006702-ekf6mja9	1127	2	:	:	:
cord-006702-ekf6mja9	1128	1	Median	median	JJ
cord-006702-ekf6mja9	1128	2	age	age	NN
cord-006702-ekf6mja9	1128	3	at	at	IN
cord-006702-ekf6mja9	1128	4	first	first	JJ
cord-006702-ekf6mja9	1128	5	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1128	6	dose	dose	NN
cord-006702-ekf6mja9	1128	7	was	be	VBD
cord-006702-ekf6mja9	1129	1	8.0	8.0	CD
cord-006702-ekf6mja9	1129	2	(	(	-LRB-
cord-006702-ekf6mja9	1129	3	range	range	NN
cord-006702-ekf6mja9	1129	4	0	0	CD
cord-006702-ekf6mja9	1129	5	-	-	SYM
cord-006702-ekf6mja9	1129	6	17	17	CD
cord-006702-ekf6mja9	1129	7	)	)	-RRB-
cord-006702-ekf6mja9	1129	8	years	year	NNS
cord-006702-ekf6mja9	1129	9	and	and	CC
cord-006702-ekf6mja9	1129	10	median	median	JJ
cord-006702-ekf6mja9	1129	11	follow	follow	NN
cord-006702-ekf6mja9	1129	12	-	-	HYPH
cord-006702-ekf6mja9	1129	13	up	up	NN
cord-006702-ekf6mja9	1129	14	from	from	IN
cord-006702-ekf6mja9	1129	15	first	first	JJ
cord-006702-ekf6mja9	1129	16	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1129	17	dose	dose	NN
cord-006702-ekf6mja9	1129	18	was	be	VBD
cord-006702-ekf6mja9	1129	19	48.9	48.9	CD
cord-006702-ekf6mja9	1129	20	(	(	-LRB-
cord-006702-ekf6mja9	1129	21	range	range	NNP
cord-006702-ekf6mja9	1129	22	35.1	35.1	CD
cord-006702-ekf6mja9	1129	23	-	-	HYPH
cord-006702-ekf6mja9	1129	24	78.5	78.5	CD
cord-006702-ekf6mja9	1129	25	)	)	-RRB-
cord-006702-ekf6mja9	1129	26	months	month	NNS
cord-006702-ekf6mja9	1129	27	(	(	-LRB-
cord-006702-ekf6mja9	1129	28	N=35	N=35	NNP
cord-006702-ekf6mja9	1129	29	)	)	-RRB-
cord-006702-ekf6mja9	1129	30	.	.	.
cord-006702-ekf6mja9	1130	1	At	at	RB
cord-006702-ekf6mja9	1130	2	least	least	JJS
cord-006702-ekf6mja9	1130	3	1	1	CD
cord-006702-ekf6mja9	1130	4	complement	complement	NN
cord-006702-ekf6mja9	1130	5	abnormality	abnormality	NN
cord-006702-ekf6mja9	1130	6	was	be	VBD
cord-006702-ekf6mja9	1130	7	identified	identify	VBN
cord-006702-ekf6mja9	1130	8	in	in	IN
cord-006702-ekf6mja9	1130	9	21	21	CD
cord-006702-ekf6mja9	1130	10	(	(	-LRB-
cord-006702-ekf6mja9	1130	11	60	60	CD
cord-006702-ekf6mja9	1130	12	%	%	NN
cord-006702-ekf6mja9	1130	13	)	)	-RRB-
cord-006702-ekf6mja9	1130	14	pts	pt	NNS
cord-006702-ekf6mja9	1130	15	,	,	,
cord-006702-ekf6mja9	1130	16	including	include	VBG
cord-006702-ekf6mja9	1130	17	mutations	mutation	NNS
cord-006702-ekf6mja9	1130	18	in	in	IN
cord-006702-ekf6mja9	1130	19	factor	factor	NN
cord-006702-ekf6mja9	1130	20	H	h	NN
cord-006702-ekf6mja9	1130	21	(	(	-LRB-
cord-006702-ekf6mja9	1130	22	9	9	CD
cord-006702-ekf6mja9	1130	23	pts	pts	CD
cord-006702-ekf6mja9	1130	24	)	)	-RRB-
cord-006702-ekf6mja9	1130	25	,	,	,
cord-006702-ekf6mja9	1130	26	membrane	membrane	NN
cord-006702-ekf6mja9	1130	27	cofactor	cofactor	NN
cord-006702-ekf6mja9	1130	28	protein	protein	NN
cord-006702-ekf6mja9	1130	29	(	(	-LRB-
cord-006702-ekf6mja9	1130	30	3	3	CD
cord-006702-ekf6mja9	1130	31	pts	pts	CD
cord-006702-ekf6mja9	1130	32	)	)	-RRB-
cord-006702-ekf6mja9	1130	33	,	,	,
cord-006702-ekf6mja9	1130	34	factor	factor	NN
cord-006702-ekf6mja9	1130	35	I	-PRON-	PRP
cord-006702-ekf6mja9	1130	36	(	(	-LRB-
cord-006702-ekf6mja9	1130	37	2	2	CD
cord-006702-ekf6mja9	1130	38	pts	pts	CD
cord-006702-ekf6mja9	1130	39	)	)	-RRB-
cord-006702-ekf6mja9	1130	40	and	and	CC
cord-006702-ekf6mja9	1130	41	C3	c3	NN
cord-006702-ekf6mja9	1130	42	(	(	-LRB-
cord-006702-ekf6mja9	1130	43	2	2	CD
cord-006702-ekf6mja9	1130	44	pts	pts	CD
cord-006702-ekf6mja9	1130	45	)	)	-RRB-
cord-006702-ekf6mja9	1130	46	.	.	.
cord-006702-ekf6mja9	1131	1	Prior	prior	RB
cord-006702-ekf6mja9	1131	2	to	to	IN
cord-006702-ekf6mja9	1131	3	first	first	JJ
cord-006702-ekf6mja9	1131	4	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1131	5	dose	dose	NN
cord-006702-ekf6mja9	1131	6	,	,	,
cord-006702-ekf6mja9	1131	7	11	11	CD
cord-006702-ekf6mja9	1131	8	(	(	-LRB-
cord-006702-ekf6mja9	1131	9	31	31	CD
cord-006702-ekf6mja9	1131	10	%	%	NN
cord-006702-ekf6mja9	1131	11	)	)	-RRB-
cord-006702-ekf6mja9	1131	12	pts	pt	NNS
cord-006702-ekf6mja9	1131	13	were	be	VBD
cord-006702-ekf6mja9	1131	14	on	on	IN
cord-006702-ekf6mja9	1131	15	dialysis	dialysis	NN
cord-006702-ekf6mja9	1131	16	and	and	CC
cord-006702-ekf6mja9	1131	17	5	5	CD
cord-006702-ekf6mja9	1131	18	(	(	-LRB-
cord-006702-ekf6mja9	1131	19	14	14	CD
cord-006702-ekf6mja9	1131	20	%	%	NN
cord-006702-ekf6mja9	1131	21	)	)	-RRB-
cord-006702-ekf6mja9	1131	22	had	have	VBD
cord-006702-ekf6mja9	1131	23	prior	prior	JJ
cord-006702-ekf6mja9	1131	24	kidney	kidney	NN
cord-006702-ekf6mja9	1131	25	transplantation	transplantation	NN
cord-006702-ekf6mja9	1131	26	.	.	.
cord-006702-ekf6mja9	1132	1	Eight	eight	CD
cord-006702-ekf6mja9	1132	2	(	(	-LRB-
cord-006702-ekf6mja9	1132	3	23	23	CD
cord-006702-ekf6mja9	1132	4	%	%	NN
cord-006702-ekf6mja9	1132	5	)	)	-RRB-
cord-006702-ekf6mja9	1132	6	pts	pt	NNS
cord-006702-ekf6mja9	1132	7	had	have	VBD
cord-006702-ekf6mja9	1132	8	experienced	experience	VBN
cord-006702-ekf6mja9	1132	9	≥2	≥2	NNP
cord-006702-ekf6mja9	1132	10	thrombotic	thrombotic	JJ
cord-006702-ekf6mja9	1132	11	microangiopathy	microangiopathy	NNP
cord-006702-ekf6mja9	1132	12	events	event	NNS
cord-006702-ekf6mja9	1132	13	prior	prior	RB
cord-006702-ekf6mja9	1132	14	to	to	IN
cord-006702-ekf6mja9	1132	15	first	first	JJ
cord-006702-ekf6mja9	1132	16	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1132	17	dose	dose	NN
cord-006702-ekf6mja9	1132	18	.	.	.
cord-006702-ekf6mja9	1133	1	Median	median	JJ
cord-006702-ekf6mja9	1133	2	time	time	NN
cord-006702-ekf6mja9	1133	3	from	from	IN
cord-006702-ekf6mja9	1133	4	aHUS	ahus	DT
cord-006702-ekf6mja9	1133	5	diagnosis	diagnosis	NN
cord-006702-ekf6mja9	1133	6	to	to	IN
cord-006702-ekf6mja9	1133	7	first	first	JJ
cord-006702-ekf6mja9	1133	8	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1133	9	dose	dose	NN
cord-006702-ekf6mja9	1133	10	was	be	VBD
cord-006702-ekf6mja9	1133	11	3.1	3.1	CD
cord-006702-ekf6mja9	1133	12	(	(	-LRB-
cord-006702-ekf6mja9	1133	13	range	range	NN
cord-006702-ekf6mja9	1133	14	0	0	CD
cord-006702-ekf6mja9	1133	15	-	-	HYPH
cord-006702-ekf6mja9	1133	16	178.1	178.1	CD
cord-006702-ekf6mja9	1133	17	)	)	-RRB-
cord-006702-ekf6mja9	1133	18	months	month	NNS
cord-006702-ekf6mja9	1133	19	.	.	.
cord-006702-ekf6mja9	1134	1	Improvement	improvement	NN
cord-006702-ekf6mja9	1134	2	in	in	IN
cord-006702-ekf6mja9	1134	3	renal	renal	JJ
cord-006702-ekf6mja9	1134	4	function	function	NN
cord-006702-ekf6mja9	1134	5	(	(	-LRB-
cord-006702-ekf6mja9	1134	6	increase	increase	NN
cord-006702-ekf6mja9	1134	7	in	in	IN
cord-006702-ekf6mja9	1134	8	estimated	estimate	VBN
cord-006702-ekf6mja9	1134	9	glomerular	glomerular	JJ
cord-006702-ekf6mja9	1134	10	filtration	filtration	NN
cord-006702-ekf6mja9	1134	11	rate	rate	NN
cord-006702-ekf6mja9	1134	12	)	)	-RRB-
cord-006702-ekf6mja9	1134	13	following	follow	VBG
cord-006702-ekf6mja9	1134	14	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1134	15	initiation	initiation	NN
cord-006702-ekf6mja9	1134	16	,	,	,
cord-006702-ekf6mja9	1134	17	was	be	VBD
cord-006702-ekf6mja9	1134	18	maintained	maintain	VBN
cord-006702-ekf6mja9	1134	19	(	(	-LRB-
cord-006702-ekf6mja9	1134	20	figure	figure	NN
cord-006702-ekf6mja9	1134	21	1	1	CD
cord-006702-ekf6mja9	1134	22	)	)	-RRB-
cord-006702-ekf6mja9	1134	23	,	,	,
cord-006702-ekf6mja9	1134	24	and	and	CC
cord-006702-ekf6mja9	1134	25	dialysis	dialysis	NN
cord-006702-ekf6mja9	1134	26	was	be	VBD
cord-006702-ekf6mja9	1134	27	stopped	stop	VBN
cord-006702-ekf6mja9	1134	28	in	in	IN
cord-006702-ekf6mja9	1134	29	9	9	CD
cord-006702-ekf6mja9	1134	30	(	(	-LRB-
cord-006702-ekf6mja9	1134	31	82	82	CD
cord-006702-ekf6mja9	1134	32	%	%	NN
cord-006702-ekf6mja9	1134	33	)	)	-RRB-
cord-006702-ekf6mja9	1134	34	pts	pts	NN
cord-006702-ekf6mja9	1134	35	.	.	.
cord-006702-ekf6mja9	1135	1	Two	two	CD
cord-006702-ekf6mja9	1135	2	(	(	-LRB-
cord-006702-ekf6mja9	1135	3	18	18	CD
cord-006702-ekf6mja9	1135	4	%	%	NN
cord-006702-ekf6mja9	1135	5	)	)	-RRB-
cord-006702-ekf6mja9	1135	6	pts	pt	NNS
cord-006702-ekf6mja9	1135	7	remained	remain	VBD
cord-006702-ekf6mja9	1135	8	on	on	IN
cord-006702-ekf6mja9	1135	9	dialysis	dialysis	NN
cord-006702-ekf6mja9	1135	10	throughout	throughout	IN
cord-006702-ekf6mja9	1135	11	the	the	DT
cord-006702-ekf6mja9	1135	12	study	study	NN
cord-006702-ekf6mja9	1135	13	.	.	.
cord-006702-ekf6mja9	1136	1	No	no	DT
cord-006702-ekf6mja9	1136	2	new	new	JJ
cord-006702-ekf6mja9	1136	3	dialysis	dialysis	NN
cord-006702-ekf6mja9	1136	4	or	or	CC
cord-006702-ekf6mja9	1136	5	kidney	kidney	NN
cord-006702-ekf6mja9	1136	6	transplants	transplant	NNS
cord-006702-ekf6mja9	1136	7	occurred	occur	VBD
cord-006702-ekf6mja9	1136	8	.	.	.
cord-006702-ekf6mja9	1137	1	During	during	IN
cord-006702-ekf6mja9	1137	2	this	this	DT
cord-006702-ekf6mja9	1137	3	follow	follow	NN
cord-006702-ekf6mja9	1137	4	-	-	HYPH
cord-006702-ekf6mja9	1137	5	up	up	NN
cord-006702-ekf6mja9	1137	6	study	study	NN
cord-006702-ekf6mja9	1137	7	,	,	,
cord-006702-ekf6mja9	1137	8	no	no	DT
cord-006702-ekf6mja9	1137	9	pts	pts	NN
cord-006702-ekf6mja9	1137	10	died	die	VBD
cord-006702-ekf6mja9	1137	11	,	,	,
cord-006702-ekf6mja9	1137	12	7	7	CD
cord-006702-ekf6mja9	1137	13	(	(	-LRB-
cord-006702-ekf6mja9	1137	14	23	23	CD
cord-006702-ekf6mja9	1137	15	%	%	NN
cord-006702-ekf6mja9	1137	16	)	)	-RRB-
cord-006702-ekf6mja9	1137	17	pts	pts	CD
cord-006702-ekf6mja9	1137	18	experienced	experience	VBD
cord-006702-ekf6mja9	1137	19	a	a	DT
cord-006702-ekf6mja9	1137	20	total	total	NN
cord-006702-ekf6mja9	1137	21	of	of	IN
cord-006702-ekf6mja9	1137	22	9	9	CD
cord-006702-ekf6mja9	1137	23	TSAEs	tsae	NNS
cord-006702-ekf6mja9	1137	24	,	,	,
cord-006702-ekf6mja9	1137	25	including	include	VBG
cord-006702-ekf6mja9	1137	26	2	2	CD
cord-006702-ekf6mja9	1137	27	meningococcal	meningococcal	JJ
cord-006702-ekf6mja9	1137	28	infections	infection	NNS
cord-006702-ekf6mja9	1137	29	.	.	.
cord-006702-ekf6mja9	1138	1	Both	both	DT
cord-006702-ekf6mja9	1138	2	pts	pt	NNS
cord-006702-ekf6mja9	1138	3	recovered	recover	VBD
cord-006702-ekf6mja9	1138	4	and	and	CC
cord-006702-ekf6mja9	1138	5	remained	remain	VBD
cord-006702-ekf6mja9	1138	6	on	on	IN
cord-006702-ekf6mja9	1138	7	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1138	8	.	.	.
cord-006702-ekf6mja9	1138	9	&	&	CC
cord-006702-ekf6mja9	1138	10	Figure	Figure	NNP
cord-006702-ekf6mja9	1138	11	1	1	CD
cord-006702-ekf6mja9	1138	12	.	.	.
cord-006702-ekf6mja9	1139	1	Mean	mean	JJ
cord-006702-ekf6mja9	1139	2	estimated	estimate	VBD
cord-006702-ekf6mja9	1139	3	glomerular	glomerular	JJ
cord-006702-ekf6mja9	1139	4	filtration	filtration	NN
cord-006702-ekf6mja9	1139	5	rate	rate	NN
cord-006702-ekf6mja9	1139	6	(	(	-LRB-
cord-006702-ekf6mja9	1139	7	+	+	CC
cord-006702-ekf6mja9	1139	8	/-SD	/-sd	NN
cord-006702-ekf6mja9	1139	9	)	)	-RRB-
cord-006702-ekf6mja9	1140	1	over	over	IN
cord-006702-ekf6mja9	1140	2	time	time	NN
cord-006702-ekf6mja9	1140	3	,	,	,
cord-006702-ekf6mja9	1140	4	in	in	IN
cord-006702-ekf6mja9	1140	5	pts	pts	NN
cord-006702-ekf6mja9	1140	6	with	with	IN
cord-006702-ekf6mja9	1140	7	ongoing	ongoing	JJ
cord-006702-ekf6mja9	1140	8	treatment	treatment	NN
cord-006702-ekf6mja9	1140	9	with	with	IN
cord-006702-ekf6mja9	1140	10	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1140	11	Conclusions	Conclusions	NNPS
cord-006702-ekf6mja9	1140	12	:	:	:
cord-006702-ekf6mja9	1140	13	This	this	DT
cord-006702-ekf6mja9	1140	14	is	be	VBZ
cord-006702-ekf6mja9	1140	15	the	the	DT
cord-006702-ekf6mja9	1140	16	first	first	JJ
cord-006702-ekf6mja9	1140	17	report	report	NN
cord-006702-ekf6mja9	1140	18	to	to	TO
cord-006702-ekf6mja9	1140	19	include	include	VB
cord-006702-ekf6mja9	1140	20	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1140	21	pts	pt	NNS
cord-006702-ekf6mja9	1140	22	with	with	IN
cord-006702-ekf6mja9	1140	23	aHUS	ahus	DT
cord-006702-ekf6mja9	1140	24	treated	treat	VBN
cord-006702-ekf6mja9	1140	25	with	with	IN
cord-006702-ekf6mja9	1140	26	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1140	27	for	for	IN
cord-006702-ekf6mja9	1140	28	over	over	IN
cord-006702-ekf6mja9	1140	29	5	5	CD
cord-006702-ekf6mja9	1140	30	years	year	NNS
cord-006702-ekf6mja9	1140	31	.	.	.
cord-006702-ekf6mja9	1141	1	Throughout	throughout	IN
cord-006702-ekf6mja9	1141	2	this	this	DT
cord-006702-ekf6mja9	1141	3	follow	follow	NN
cord-006702-ekf6mja9	1141	4	-	-	HYPH
cord-006702-ekf6mja9	1141	5	up	up	NN
cord-006702-ekf6mja9	1141	6	period	period	NN
cord-006702-ekf6mja9	1141	7	,	,	,
cord-006702-ekf6mja9	1141	8	Ecu	Ecu	NNP
cord-006702-ekf6mja9	1141	9	was	be	VBD
cord-006702-ekf6mja9	1141	10	generally	generally	RB
cord-006702-ekf6mja9	1141	11	well	well	RB
cord-006702-ekf6mja9	1141	12	tolerated	tolerate	VBN
cord-006702-ekf6mja9	1141	13	and	and	CC
cord-006702-ekf6mja9	1141	14	effective	effective	JJ
cord-006702-ekf6mja9	1141	15	in	in	IN
cord-006702-ekf6mja9	1141	16	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1141	17	pts	pts	NN
cord-006702-ekf6mja9	1141	18	.	.	.
cord-006702-ekf6mja9	1142	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1142	2	:	:	:
cord-006702-ekf6mja9	1143	1	Elevated	elevated	JJ
cord-006702-ekf6mja9	1143	2	intact	intact	JJ
cord-006702-ekf6mja9	1143	3	parathyroid	parathyroid	JJ
cord-006702-ekf6mja9	1143	4	hormone	hormone	NN
cord-006702-ekf6mja9	1143	5	(	(	-LRB-
cord-006702-ekf6mja9	1143	6	iPTH	iPTH	NNP
cord-006702-ekf6mja9	1143	7	)	)	-RRB-
cord-006702-ekf6mja9	1143	8	levels	level	NNS
cord-006702-ekf6mja9	1143	9	can	can	MD
cord-006702-ekf6mja9	1143	10	contribute	contribute	VB
cord-006702-ekf6mja9	1143	11	to	to	IN
cord-006702-ekf6mja9	1143	12	morbidity	morbidity	NN
cord-006702-ekf6mja9	1143	13	and	and	CC
cord-006702-ekf6mja9	1143	14	mortality	mortality	NN
cord-006702-ekf6mja9	1143	15	in	in	IN
cord-006702-ekf6mja9	1143	16	children	child	NNS
cord-006702-ekf6mja9	1143	17	with	with	IN
cord-006702-ekf6mja9	1143	18	chronic	chronic	JJ
cord-006702-ekf6mja9	1143	19	kidney	kidney	NN
cord-006702-ekf6mja9	1143	20	disease	disease	NN
cord-006702-ekf6mja9	1143	21	(	(	-LRB-
cord-006702-ekf6mja9	1143	22	CKD	CKD	NNP
cord-006702-ekf6mja9	1143	23	)	)	-RRB-
cord-006702-ekf6mja9	1143	24	.	.	.
cord-006702-ekf6mja9	1144	1	The	the	DT
cord-006702-ekf6mja9	1144	2	present	present	JJ
cord-006702-ekf6mja9	1144	3	studies	study	NNS
cord-006702-ekf6mja9	1144	4	evaluated	evaluate	VBD
cord-006702-ekf6mja9	1144	5	the	the	DT
cord-006702-ekf6mja9	1144	6	pharmacokinetics	pharmacokinetic	NNS
cord-006702-ekf6mja9	1144	7	,	,	,
cord-006702-ekf6mja9	1144	8	efficacy	efficacy	NN
cord-006702-ekf6mja9	1144	9	,	,	,
cord-006702-ekf6mja9	1144	10	and	and	CC
cord-006702-ekf6mja9	1144	11	safety	safety	NN
cord-006702-ekf6mja9	1144	12	of	of	IN
cord-006702-ekf6mja9	1144	13	oral	oral	JJ
cord-006702-ekf6mja9	1144	14	paricalcitol	paricalcitol	NN
cord-006702-ekf6mja9	1144	15	in	in	IN
cord-006702-ekf6mja9	1144	16	the	the	DT
cord-006702-ekf6mja9	1144	17	reduction	reduction	NN
cord-006702-ekf6mja9	1144	18	of	of	IN
cord-006702-ekf6mja9	1144	19	iPTH	ipth	JJ
cord-006702-ekf6mja9	1144	20	levels	level	NNS
cord-006702-ekf6mja9	1144	21	in	in	IN
cord-006702-ekf6mja9	1144	22	children	child	NNS
cord-006702-ekf6mja9	1144	23	with	with	IN
cord-006702-ekf6mja9	1144	24	stages	stage	NNS
cord-006702-ekf6mja9	1144	25	3	3	CD
cord-006702-ekf6mja9	1144	26	-	-	SYM
cord-006702-ekf6mja9	1144	27	5	5	CD
cord-006702-ekf6mja9	1144	28	CKD	CKD	NNP
cord-006702-ekf6mja9	1144	29	.	.	.
cord-006702-ekf6mja9	1145	1	Methods	method	NNS
cord-006702-ekf6mja9	1145	2	:	:	:
cord-006702-ekf6mja9	1145	3	Two	two	CD
cord-006702-ekf6mja9	1145	4	phase	phase	NN
cord-006702-ekf6mja9	1145	5	3	3	CD
cord-006702-ekf6mja9	1145	6	studies	study	NNS
cord-006702-ekf6mja9	1145	7	enrolled	enrol	VBD
cord-006702-ekf6mja9	1145	8	children	child	NNS
cord-006702-ekf6mja9	1145	9	aged	age	VBN
cord-006702-ekf6mja9	1145	10	10	10	CD
cord-006702-ekf6mja9	1145	11	-	-	SYM
cord-006702-ekf6mja9	1145	12	16	16	CD
cord-006702-ekf6mja9	1145	13	years	year	NNS
cord-006702-ekf6mja9	1145	14	with	with	IN
cord-006702-ekf6mja9	1145	15	stages	stage	NNS
cord-006702-ekf6mja9	1145	16	3	3	CD
cord-006702-ekf6mja9	1145	17	-	-	SYM
cord-006702-ekf6mja9	1145	18	5	5	CD
cord-006702-ekf6mja9	1145	19	CKD	CKD	NNP
cord-006702-ekf6mja9	1145	20	.	.	.
cord-006702-ekf6mja9	1146	1	The	the	DT
cord-006702-ekf6mja9	1146	2	first	first	JJ
cord-006702-ekf6mja9	1146	3	study	study	NN
cord-006702-ekf6mja9	1146	4	evaluated	evaluate	VBD
cord-006702-ekf6mja9	1146	5	oral	oral	JJ
cord-006702-ekf6mja9	1146	6	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1146	7	pharmacokinetics	pharmacokinetics	NNP
cord-006702-ekf6mja9	1146	8	,	,	,
cord-006702-ekf6mja9	1146	9	efficacy	efficacy	NN
cord-006702-ekf6mja9	1146	10	,	,	,
cord-006702-ekf6mja9	1146	11	and	and	CC
cord-006702-ekf6mja9	1146	12	safety	safety	NN
cord-006702-ekf6mja9	1146	13	in	in	IN
cord-006702-ekf6mja9	1146	14	children	child	NNS
cord-006702-ekf6mja9	1146	15	with	with	IN
cord-006702-ekf6mja9	1146	16	stage	stage	NN
cord-006702-ekf6mja9	1146	17	3/4	3/4	CD
cord-006702-ekf6mja9	1146	18	CKD	CKD	NNP
cord-006702-ekf6mja9	1146	19	with	with	IN
cord-006702-ekf6mja9	1146	20	an	an	DT
cord-006702-ekf6mja9	1146	21	initial	initial	JJ
cord-006702-ekf6mja9	1146	22	12-week	12-week	JJ
cord-006702-ekf6mja9	1146	23	doubleblind	doubleblind	NN
cord-006702-ekf6mja9	1146	24	period	period	NN
cord-006702-ekf6mja9	1146	25	followed	follow	VBN
cord-006702-ekf6mja9	1146	26	by	by	IN
cord-006702-ekf6mja9	1146	27	a	a	DT
cord-006702-ekf6mja9	1146	28	12-week	12-week	JJ
cord-006702-ekf6mja9	1146	29	(	(	-LRB-
cord-006702-ekf6mja9	1146	30	minimum	minimum	JJ
cord-006702-ekf6mja9	1146	31	)	)	-RRB-
cord-006702-ekf6mja9	1146	32	open	open	JJ
cord-006702-ekf6mja9	1146	33	-	-	HYPH
cord-006702-ekf6mja9	1146	34	label	label	NN
cord-006702-ekf6mja9	1146	35	period	period	NN
cord-006702-ekf6mja9	1146	36	wherein	wherein	WRB
cord-006702-ekf6mja9	1146	37	all	all	DT
cord-006702-ekf6mja9	1146	38	children	child	NNS
cord-006702-ekf6mja9	1146	39	received	receive	VBD
cord-006702-ekf6mja9	1146	40	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1146	41	.	.	.
cord-006702-ekf6mja9	1147	1	The	the	DT
cord-006702-ekf6mja9	1147	2	second	second	JJ
cord-006702-ekf6mja9	1147	3	study	study	NN
cord-006702-ekf6mja9	1147	4	evaluated	evaluate	VBD
cord-006702-ekf6mja9	1147	5	the	the	DT
cord-006702-ekf6mja9	1147	6	efficacy	efficacy	NN
cord-006702-ekf6mja9	1147	7	and	and	CC
cord-006702-ekf6mja9	1147	8	safety	safety	NN
cord-006702-ekf6mja9	1147	9	of	of	IN
cord-006702-ekf6mja9	1147	10	oral	oral	JJ
cord-006702-ekf6mja9	1147	11	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1147	12	(	(	-LRB-
cord-006702-ekf6mja9	1147	13	no	no	DT
cord-006702-ekf6mja9	1147	14	comparator	comparator	NN
cord-006702-ekf6mja9	1147	15	)	)	-RRB-
cord-006702-ekf6mja9	1147	16	for	for	IN
cord-006702-ekf6mja9	1147	17	12	12	CD
cord-006702-ekf6mja9	1147	18	weeks	week	NNS
cord-006702-ekf6mja9	1147	19	in	in	IN
cord-006702-ekf6mja9	1147	20	children	child	NNS
cord-006702-ekf6mja9	1147	21	with	with	IN
cord-006702-ekf6mja9	1147	22	stage	stage	NN
cord-006702-ekf6mja9	1147	23	5	5	CD
cord-006702-ekf6mja9	1147	24	CKD	CKD	NNP
cord-006702-ekf6mja9	1147	25	undergoing	undergo	VBG
cord-006702-ekf6mja9	1147	26	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	1147	27	or	or	CC
cord-006702-ekf6mja9	1147	28	peritoneal	peritoneal	JJ
cord-006702-ekf6mja9	1147	29	dialysis	dialysis	NN
cord-006702-ekf6mja9	1147	30	.	.	.
cord-006702-ekf6mja9	1148	1	Results	result	NNS
cord-006702-ekf6mja9	1148	2	:	:	:
cord-006702-ekf6mja9	1149	1	In	in	IN
cord-006702-ekf6mja9	1149	2	the	the	DT
cord-006702-ekf6mja9	1149	3	stage	stage	NN
cord-006702-ekf6mja9	1149	4	3/4	3/4	CD
cord-006702-ekf6mja9	1149	5	CKD	CKD	NNP
cord-006702-ekf6mja9	1149	6	study	study	NN
cord-006702-ekf6mja9	1149	7	,	,	,
cord-006702-ekf6mja9	1149	8	12	12	CD
cord-006702-ekf6mja9	1149	9	children	child	NNS
cord-006702-ekf6mja9	1149	10	received	receive	VBD
cord-006702-ekf6mja9	1149	11	3	3	CD
cord-006702-ekf6mja9	1149	12	μg	μg	NNP
cord-006702-ekf6mja9	1149	13	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1149	14	and	and	CC
cord-006702-ekf6mja9	1149	15	were	be	VBD
cord-006702-ekf6mja9	1149	16	assessed	assess	VBN
cord-006702-ekf6mja9	1149	17	for	for	IN
cord-006702-ekf6mja9	1149	18	intensive	intensive	JJ
cord-006702-ekf6mja9	1149	19	pharmacokinetics	pharmacokinetic	NNS
cord-006702-ekf6mja9	1149	20	(	(	-LRB-
cord-006702-ekf6mja9	1149	21	mean	mean	UH
cord-006702-ekf6mja9	1149	22	C	C	NNP
cord-006702-ekf6mja9	1149	23	max	max	NN
cord-006702-ekf6mja9	1149	24	,	,	,
cord-006702-ekf6mja9	1149	25	0.13	0.13	CD
cord-006702-ekf6mja9	1149	26	ng	ng	NN
cord-006702-ekf6mja9	1149	27	/	/	SYM
cord-006702-ekf6mja9	1149	28	mL	ml	NN
cord-006702-ekf6mja9	1149	29	;	;	:
cord-006702-ekf6mja9	1149	30	AUC	AUC	NNP
cord-006702-ekf6mja9	1149	31	0−∞	0−∞	CD
cord-006702-ekf6mja9	1149	32	,	,	,
cord-006702-ekf6mja9	1149	33	2.87	2.87	CD
cord-006702-ekf6mja9	1149	34	ngâ'h	ngâ'h	NNS
cord-006702-ekf6mja9	1149	35	/	/	SYM
cord-006702-ekf6mja9	1149	36	mL	ml	NN
cord-006702-ekf6mja9	1149	37	)	)	-RRB-
cord-006702-ekf6mja9	1149	38	.	.	.
cord-006702-ekf6mja9	1150	1	Population	population	NN
cord-006702-ekf6mja9	1150	2	pharmacokinetic	pharmacokinetic	JJ
cord-006702-ekf6mja9	1150	3	analysis	analysis	NN
cord-006702-ekf6mja9	1150	4	showed	show	VBD
cord-006702-ekf6mja9	1150	5	that	that	IN
cord-006702-ekf6mja9	1150	6	CKD	CKD	NNP
cord-006702-ekf6mja9	1150	7	stage	stage	NN
cord-006702-ekf6mja9	1150	8	does	do	VBZ
cord-006702-ekf6mja9	1150	9	not	not	RB
cord-006702-ekf6mja9	1150	10	influence	influence	VB
cord-006702-ekf6mja9	1150	11	the	the	DT
cord-006702-ekf6mja9	1150	12	pharmacokinetics	pharmacokinetic	NNS
cord-006702-ekf6mja9	1150	13	of	of	IN
cord-006702-ekf6mja9	1150	14	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1150	15	in	in	IN
cord-006702-ekf6mja9	1150	16	children	child	NNS
cord-006702-ekf6mja9	1150	17	.	.	.
cord-006702-ekf6mja9	1151	1	Thirty	thirty	CD
cord-006702-ekf6mja9	1151	2	-	-	HYPH
cord-006702-ekf6mja9	1151	3	six	six	CD
cord-006702-ekf6mja9	1151	4	children	child	NNS
cord-006702-ekf6mja9	1151	5	were	be	VBD
cord-006702-ekf6mja9	1151	6	randomized	randomized	JJ
cord-006702-ekf6mja9	1151	7	(	(	-LRB-
cord-006702-ekf6mja9	1151	8	baseline	baseline	NNP
cord-006702-ekf6mja9	1151	9	iPTH	ipth	JJ
cord-006702-ekf6mja9	1151	10	,	,	,
cord-006702-ekf6mja9	1151	11	150	150	CD
cord-006702-ekf6mja9	1151	12	mg	mg	NNP
cord-006702-ekf6mja9	1151	13	/	/	SYM
cord-006702-ekf6mja9	1151	14	dL	dl	NN
cord-006702-ekf6mja9	1151	15	)	)	-RRB-
cord-006702-ekf6mja9	1151	16	and	and	CC
cord-006702-ekf6mja9	1151	17	27.8	27.8	CD
cord-006702-ekf6mja9	1151	18	%	%	NN
cord-006702-ekf6mja9	1151	19	of	of	IN
cord-006702-ekf6mja9	1151	20	the	the	DT
cord-006702-ekf6mja9	1151	21	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1151	22	group	group	NNP
cord-006702-ekf6mja9	1151	23	achieved	achieve	VBD
cord-006702-ekf6mja9	1151	24	two	two	CD
cord-006702-ekf6mja9	1151	25	consecutive	consecutive	JJ
cord-006702-ekf6mja9	1151	26	iPTH	ipth	JJ
cord-006702-ekf6mja9	1151	27	reductions	reduction	NNS
cord-006702-ekf6mja9	1151	28	of	of	IN
cord-006702-ekf6mja9	1151	29	≥30	≥30	NNPS
cord-006702-ekf6mja9	1151	30	%	%	NN
cord-006702-ekf6mja9	1151	31	from	from	IN
cord-006702-ekf6mja9	1151	32	baseline	baseline	NN
cord-006702-ekf6mja9	1151	33	vs	vs	IN
cord-006702-ekf6mja9	1151	34	no	no	DT
cord-006702-ekf6mja9	1151	35	childrenin	childrenin	NN
cord-006702-ekf6mja9	1151	36	the	the	DT
cord-006702-ekf6mja9	1151	37	placebo	placebo	NN
cord-006702-ekf6mja9	1151	38	group	group	NN
cord-006702-ekf6mja9	1151	39	(	(	-LRB-
cord-006702-ekf6mja9	1151	40	P=0.045	p=0.045	NN
cord-006702-ekf6mja9	1151	41	)	)	-RRB-
cord-006702-ekf6mja9	1151	42	.	.	.
cord-006702-ekf6mja9	1152	1	Adverse	adverse	JJ
cord-006702-ekf6mja9	1152	2	events	event	NNS
cord-006702-ekf6mja9	1152	3	were	be	VBD
cord-006702-ekf6mja9	1152	4	observed	observe	VBN
cord-006702-ekf6mja9	1152	5	in	in	IN
cord-006702-ekf6mja9	1152	6	a	a	DT
cord-006702-ekf6mja9	1152	7	higher	high	JJR
cord-006702-ekf6mja9	1152	8	proportion	proportion	NN
cord-006702-ekf6mja9	1152	9	of	of	IN
cord-006702-ekf6mja9	1152	10	the	the	DT
cord-006702-ekf6mja9	1152	11	placebo	placebo	NN
cord-006702-ekf6mja9	1152	12	group	group	NN
cord-006702-ekf6mja9	1152	13	compared	compare	VBN
cord-006702-ekf6mja9	1152	14	with	with	IN
cord-006702-ekf6mja9	1152	15	the	the	DT
cord-006702-ekf6mja9	1152	16	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1152	17	group	group	NN
cord-006702-ekf6mja9	1152	18	in	in	IN
cord-006702-ekf6mja9	1152	19	the	the	DT
cord-006702-ekf6mja9	1152	20	double	double	JJ
cord-006702-ekf6mja9	1152	21	-	-	HYPH
cord-006702-ekf6mja9	1152	22	blind	blind	JJ
cord-006702-ekf6mja9	1152	23	(	(	-LRB-
cord-006702-ekf6mja9	1152	24	88.9	88.9	CD
cord-006702-ekf6mja9	1152	25	%	%	NN
cord-006702-ekf6mja9	1152	26	vs	vs	IN
cord-006702-ekf6mja9	1152	27	38.9	38.9	CD
cord-006702-ekf6mja9	1152	28	%	%	NN
cord-006702-ekf6mja9	1152	29	;	;	:
cord-006702-ekf6mja9	1152	30	P=0.005	p=0.005	NN
cord-006702-ekf6mja9	1152	31	)	)	-RRB-
cord-006702-ekf6mja9	1152	32	portion	portion	NN
cord-006702-ekf6mja9	1152	33	of	of	IN
cord-006702-ekf6mja9	1152	34	the	the	DT
cord-006702-ekf6mja9	1152	35	stage	stage	NN
cord-006702-ekf6mja9	1152	36	3/4	3/4	CD
cord-006702-ekf6mja9	1152	37	CKD	CKD	NNP
cord-006702-ekf6mja9	1152	38	study	study	NN
cord-006702-ekf6mja9	1152	39	.	.	.
cord-006702-ekf6mja9	1153	1	In	in	IN
cord-006702-ekf6mja9	1153	2	the	the	DT
cord-006702-ekf6mja9	1153	3	stage	stage	NN
cord-006702-ekf6mja9	1153	4	5	5	CD
cord-006702-ekf6mja9	1153	5	CKD	CKD	NNP
cord-006702-ekf6mja9	1153	6	study	study	NN
cord-006702-ekf6mja9	1153	7	,	,	,
cord-006702-ekf6mja9	1153	8	8	8	CD
cord-006702-ekf6mja9	1153	9	of	of	IN
cord-006702-ekf6mja9	1153	10	the	the	DT
cord-006702-ekf6mja9	1153	11	13	13	CD
cord-006702-ekf6mja9	1153	12	(	(	-LRB-
cord-006702-ekf6mja9	1153	13	61.5	61.5	CD
cord-006702-ekf6mja9	1153	14	%	%	NN
cord-006702-ekf6mja9	1153	15	)	)	-RRB-
cord-006702-ekf6mja9	1153	16	children	child	NNS
cord-006702-ekf6mja9	1153	17	enrolled	enrol	VBD
cord-006702-ekf6mja9	1153	18	had	have	VBD
cord-006702-ekf6mja9	1153	19	two	two	CD
cord-006702-ekf6mja9	1153	20	consecutive	consecutive	JJ
cord-006702-ekf6mja9	1153	21	iPTH	ipth	JJ
cord-006702-ekf6mja9	1153	22	reductions	reduction	NNS
cord-006702-ekf6mja9	1153	23	of	of	IN
cord-006702-ekf6mja9	1153	24	≥30	≥30	NNPS
cord-006702-ekf6mja9	1153	25	%	%	NN
cord-006702-ekf6mja9	1153	26	from	from	IN
cord-006702-ekf6mja9	1153	27	baseline	baseline	JJ
cord-006702-ekf6mja9	1153	28	(	(	-LRB-
cord-006702-ekf6mja9	1153	29	baseline	baseline	JJ
cord-006702-ekf6mja9	1153	30	iPTH	ipth	JJ
cord-006702-ekf6mja9	1153	31	,	,	,
cord-006702-ekf6mja9	1153	32	884	884	CD
cord-006702-ekf6mja9	1153	33	pg	pg	NNP
cord-006702-ekf6mja9	1153	34	/	/	SYM
cord-006702-ekf6mja9	1153	35	mL	mL	NNP
cord-006702-ekf6mja9	1153	36	,	,	,
cord-006702-ekf6mja9	1153	37	n=13	n=13	NNP
cord-006702-ekf6mja9	1153	38	)	)	-RRB-
cord-006702-ekf6mja9	1153	39	,	,	,
cord-006702-ekf6mja9	1153	40	and	and	CC
cord-006702-ekf6mja9	1153	41	5	5	CD
cord-006702-ekf6mja9	1153	42	(	(	-LRB-
cord-006702-ekf6mja9	1153	43	38.5	38.5	CD
cord-006702-ekf6mja9	1153	44	%	%	NN
cord-006702-ekf6mja9	1153	45	)	)	-RRB-
cord-006702-ekf6mja9	1153	46	had	have	VBD
cord-006702-ekf6mja9	1153	47	two	two	CD
cord-006702-ekf6mja9	1153	48	consecutive	consecutive	JJ
cord-006702-ekf6mja9	1153	49	iPTH	ipth	JJ
cord-006702-ekf6mja9	1153	50	values	value	NNS
cord-006702-ekf6mja9	1153	51	between	between	IN
cord-006702-ekf6mja9	1153	52	150	150	CD
cord-006702-ekf6mja9	1153	53	and	and	CC
cord-006702-ekf6mja9	1153	54	300	300	CD
cord-006702-ekf6mja9	1153	55	pg/	pg/	NNS
cord-006702-ekf6mja9	1154	1	mL.	mL.	NNS
cord-006702-ekf6mja9	1154	2	Clinically	clinically	RB
cord-006702-ekf6mja9	1154	3	meaningful	meaningful	JJ
cord-006702-ekf6mja9	1154	4	hypercalcemia	hypercalcemia	NN
cord-006702-ekf6mja9	1154	5	occurred	occur	VBD
cord-006702-ekf6mja9	1154	6	in	in	IN
cord-006702-ekf6mja9	1154	7	2	2	CD
cord-006702-ekf6mja9	1154	8	(	(	-LRB-
cord-006702-ekf6mja9	1154	9	15.3	15.3	CD
cord-006702-ekf6mja9	1154	10	%	%	NN
cord-006702-ekf6mja9	1154	11	)	)	-RRB-
cord-006702-ekf6mja9	1154	12	paricalcitol	paricalcitol	NNP
cord-006702-ekf6mja9	1154	13	-	-	HYPH
cord-006702-ekf6mja9	1154	14	treated	treat	VBN
cord-006702-ekf6mja9	1154	15	children	child	NNS
cord-006702-ekf6mja9	1154	16	in	in	IN
cord-006702-ekf6mja9	1154	17	the	the	DT
cord-006702-ekf6mja9	1154	18	stage	stage	NN
cord-006702-ekf6mja9	1154	19	5	5	CD
cord-006702-ekf6mja9	1154	20	CKD	CKD	NNP
cord-006702-ekf6mja9	1154	21	study	study	NN
cord-006702-ekf6mja9	1154	22	.	.	.
cord-006702-ekf6mja9	1155	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1155	2	:	:	:
cord-006702-ekf6mja9	1156	1	Oral	oral	JJ
cord-006702-ekf6mja9	1156	2	paricalcitol	paricalcitol	NN
cord-006702-ekf6mja9	1156	3	dosing	dose	VBG
cord-006702-ekf6mja9	1156	4	in	in	IN
cord-006702-ekf6mja9	1156	5	children	child	NNS
cord-006702-ekf6mja9	1156	6	aged	age	VBN
cord-006702-ekf6mja9	1156	7	10	10	CD
cord-006702-ekf6mja9	1156	8	-	-	SYM
cord-006702-ekf6mja9	1156	9	16	16	CD
cord-006702-ekf6mja9	1156	10	years	year	NNS
cord-006702-ekf6mja9	1156	11	with	with	IN
cord-006702-ekf6mja9	1156	12	stages	stage	NNS
cord-006702-ekf6mja9	1156	13	3	3	CD
cord-006702-ekf6mja9	1156	14	-	-	SYM
cord-006702-ekf6mja9	1156	15	5	5	CD
cord-006702-ekf6mja9	1156	16	CKD	CKD	NNP
cord-006702-ekf6mja9	1156	17	reduced	reduce	VBN
cord-006702-ekf6mja9	1156	18	iPTH	ipth	JJ
cord-006702-ekf6mja9	1156	19	levels	level	NNS
cord-006702-ekf6mja9	1156	20	and	and	CC
cord-006702-ekf6mja9	1156	21	was	be	VBD
cord-006702-ekf6mja9	1156	22	well	well	RB
cord-006702-ekf6mja9	1156	23	tolerated	tolerate	VBN
cord-006702-ekf6mja9	1156	24	.	.	.
cord-006702-ekf6mja9	1157	1	FP	FP	NNP
cord-006702-ekf6mja9	1157	2	-	-	HYPH
cord-006702-ekf6mja9	1157	3	S31	S31	NNP
cord-006702-ekf6mja9	1157	4	-	-	HYPH
cord-006702-ekf6mja9	1157	5	2	2	CD
cord-006702-ekf6mja9	1157	6	Calcimimetic	Calcimimetic	NNP
cord-006702-ekf6mja9	1157	7	(	(	-LRB-
cord-006702-ekf6mja9	1157	8	Cinacalcet	Cinacalcet	NNP
cord-006702-ekf6mja9	1157	9	)	)	-RRB-
cord-006702-ekf6mja9	1157	10	and	and	CC
cord-006702-ekf6mja9	1157	11	hemodiafiltration	hemodiafiltration	NN
cord-006702-ekf6mja9	1157	12	versus	versus	IN
cord-006702-ekf6mja9	1157	13	conventional	conventional	JJ
cord-006702-ekf6mja9	1157	14	treatment	treatment	NN
cord-006702-ekf6mja9	1157	15	of	of	IN
cord-006702-ekf6mja9	1157	16	secondary	secondary	JJ
cord-006702-ekf6mja9	1157	17	hyperparathyroidism	hyperparathyroidism	NN
cord-006702-ekf6mja9	1157	18	in	in	IN
cord-006702-ekf6mja9	1157	19	children	child	NNS
cord-006702-ekf6mja9	1157	20	with	with	IN
cord-006702-ekf6mja9	1157	21	End	end	NN
cord-006702-ekf6mja9	1157	22	-	-	HYPH
cord-006702-ekf6mja9	1157	23	Stage	stage	NN
cord-006702-ekf6mja9	1157	24	Renal	Renal	NNP
cord-006702-ekf6mja9	1157	25	Disease	Disease	NNP
cord-006702-ekf6mja9	1157	26	on	on	IN
cord-006702-ekf6mja9	1157	27	regular	regular	JJ
cord-006702-ekf6mja9	1157	28	Hemodialysis	Hemodialysis	NNP
cord-006702-ekf6mja9	1157	29	R.	R.	NNP
cord-006702-ekf6mja9	1157	30	Galal	Galal	NNP
cord-006702-ekf6mja9	1157	31	(	(	-LRB-
cord-006702-ekf6mja9	1157	32	1	1	CD
cord-006702-ekf6mja9	1157	33	)	)	-RRB-
cord-006702-ekf6mja9	1157	34	,	,	,
cord-006702-ekf6mja9	1157	35	F.	F.	NNP
cord-006702-ekf6mja9	1157	36	Fadel	Fadel	NNP
cord-006702-ekf6mja9	1157	37	(	(	-LRB-
cord-006702-ekf6mja9	1157	38	1	1	CD
cord-006702-ekf6mja9	1157	39	)	)	-RRB-
cord-006702-ekf6mja9	1157	40	,	,	,
cord-006702-ekf6mja9	1157	41	S.	S.	NNP
cord-006702-ekf6mja9	1157	42	Sabry	Sabry	NNP
cord-006702-ekf6mja9	1157	43	(	(	-LRB-
cord-006702-ekf6mja9	1157	44	1	1	CD
cord-006702-ekf6mja9	1157	45	)	)	-RRB-
cord-006702-ekf6mja9	1157	46	,	,	,
cord-006702-ekf6mja9	1157	47	M.	M.	NNP
cord-006702-ekf6mja9	1157	48	Farouk	Farouk	NNP
cord-006702-ekf6mja9	1157	49	(	(	-LRB-
cord-006702-ekf6mja9	1157	50	1	1	CD
cord-006702-ekf6mja9	1157	51	)	)	-RRB-
cord-006702-ekf6mja9	1157	52	,	,	,
cord-006702-ekf6mja9	1157	53	M.	M.	NNP
cord-006702-ekf6mja9	1157	54	Ghonim	Ghonim	NNP
cord-006702-ekf6mja9	1157	55	(	(	-LRB-
cord-006702-ekf6mja9	1157	56	2	2	CD
cord-006702-ekf6mja9	1157	57	)	)	-RRB-
cord-006702-ekf6mja9	1157	58	,	,	,
cord-006702-ekf6mja9	1157	59	A.	A.	NNP
cord-006702-ekf6mja9	1157	60	Ismail	Ismail	NNP
cord-006702-ekf6mja9	1157	61	(	(	-LRB-
cord-006702-ekf6mja9	1157	62	1	1	CD
cord-006702-ekf6mja9	1157	63	)	)	-RRB-
cord-006702-ekf6mja9	1157	64	(	(	-LRB-
cord-006702-ekf6mja9	1157	65	1	1	LS
cord-006702-ekf6mja9	1157	66	)	)	-RRB-
cord-006702-ekf6mja9	1157	67	Cairo	Cairo	NNP
cord-006702-ekf6mja9	1157	68	University	University	NNP
cord-006702-ekf6mja9	1157	69	,	,	,
cord-006702-ekf6mja9	1157	70	Cairo	Cairo	NNP
cord-006702-ekf6mja9	1157	71	,	,	,
cord-006702-ekf6mja9	1157	72	Egypt	Egypt	NNP
cord-006702-ekf6mja9	1157	73	;	;	:
cord-006702-ekf6mja9	1158	1	(	(	-LRB-
cord-006702-ekf6mja9	1158	2	2	2	LS
cord-006702-ekf6mja9	1158	3	)	)	-RRB-
cord-006702-ekf6mja9	1158	4	Ministry	Ministry	NNP
cord-006702-ekf6mja9	1158	5	of	of	IN
cord-006702-ekf6mja9	1158	6	Health	Health	NNP
cord-006702-ekf6mja9	1158	7	Hospitals	Hospitals	NNPS
cord-006702-ekf6mja9	1158	8	,	,	,
cord-006702-ekf6mja9	1158	9	Cairo	Cairo	NNP
cord-006702-ekf6mja9	1158	10	,	,	,
cord-006702-ekf6mja9	1158	11	Egypt	Egypt	NNP
cord-006702-ekf6mja9	1158	12	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1158	13	:	:	:
cord-006702-ekf6mja9	1159	1	To	to	TO
cord-006702-ekf6mja9	1159	2	compare	compare	VB
cord-006702-ekf6mja9	1159	3	the	the	DT
cord-006702-ekf6mja9	1159	4	efficacy	efficacy	NN
cord-006702-ekf6mja9	1159	5	of	of	IN
cord-006702-ekf6mja9	1159	6	2	2	CD
cord-006702-ekf6mja9	1159	7	treatment	treatment	NN
cord-006702-ekf6mja9	1159	8	strategies	strategy	NNS
cord-006702-ekf6mja9	1159	9	,	,	,
cord-006702-ekf6mja9	1159	10	namely	namely	RB
cord-006702-ekf6mja9	1159	11	cinacalcet	cinacalcet	NNP
cord-006702-ekf6mja9	1159	12	-	-	HYPH
cord-006702-ekf6mja9	1159	13	based	base	VBN
cord-006702-ekf6mja9	1159	14	regimen	regimen	NN
cord-006702-ekf6mja9	1159	15	and	and	CC
cord-006702-ekf6mja9	1159	16	hemodiafiltration	hemodiafiltration	NN
cord-006702-ekf6mja9	1159	17	modality	modality	NN
cord-006702-ekf6mja9	1159	18	,	,	,
cord-006702-ekf6mja9	1159	19	with	with	IN
cord-006702-ekf6mja9	1159	20	conventional	conventional	JJ
cord-006702-ekf6mja9	1159	21	care	care	NN
cord-006702-ekf6mja9	1159	22	(	(	-LRB-
cord-006702-ekf6mja9	1159	23	vitamin	vitamin	NN
cord-006702-ekf6mja9	1159	24	D	d	NN
cord-006702-ekf6mja9	1159	25	and	and	CC
cord-006702-ekf6mja9	1159	26	phosphate	phosphate	NN
cord-006702-ekf6mja9	1159	27	binders	binder	NNS
cord-006702-ekf6mja9	1159	28	)	)	-RRB-
cord-006702-ekf6mja9	1159	29	for	for	IN
cord-006702-ekf6mja9	1159	30	control	control	NN
cord-006702-ekf6mja9	1159	31	of	of	IN
cord-006702-ekf6mja9	1159	32	hyperparathyroidism	hyperparathyroidism	NN
cord-006702-ekf6mja9	1159	33	and	and	CC
cord-006702-ekf6mja9	1159	34	the	the	DT
cord-006702-ekf6mja9	1159	35	high	high	JJ
cord-006702-ekf6mja9	1159	36	calcium	calcium	NN
cord-006702-ekf6mja9	1159	37	phosphorus	phosphorus	NN
cord-006702-ekf6mja9	1159	38	product	product	NN
cord-006702-ekf6mja9	1159	39	in	in	IN
cord-006702-ekf6mja9	1159	40	order	order	NN
cord-006702-ekf6mja9	1159	41	to	to	TO
cord-006702-ekf6mja9	1159	42	achieve	achieve	VB
cord-006702-ekf6mja9	1159	43	the	the	DT
cord-006702-ekf6mja9	1159	44	recommended	recommend	VBN
cord-006702-ekf6mja9	1159	45	targets	target	NNS
cord-006702-ekf6mja9	1159	46	of	of	IN
cord-006702-ekf6mja9	1159	47	the	the	DT
cord-006702-ekf6mja9	1159	48	NKF	NKF	NNP
cord-006702-ekf6mja9	1159	49	/	/	SYM
cord-006702-ekf6mja9	1159	50	DOQI	DOQI	NNP
cord-006702-ekf6mja9	1159	51	guidelines	guideline	NNS
cord-006702-ekf6mja9	1159	52	.	.	.
cord-006702-ekf6mja9	1160	1	Methods	method	NNS
cord-006702-ekf6mja9	1160	2	:	:	:
cord-006702-ekf6mja9	1160	3	A	a	DT
cord-006702-ekf6mja9	1160	4	case	case	NN
cord-006702-ekf6mja9	1160	5	-control	-control	JJ
cord-006702-ekf6mja9	1160	6	study	study	NN
cord-006702-ekf6mja9	1160	7	was	be	VBD
cord-006702-ekf6mja9	1160	8	performed	perform	VBN
cord-006702-ekf6mja9	1160	9	over	over	IN
cord-006702-ekf6mja9	1160	10	6	6	CD
cord-006702-ekf6mja9	1160	11	months	month	NNS
cord-006702-ekf6mja9	1160	12	on	on	IN
cord-006702-ekf6mja9	1160	13	33	33	CD
cord-006702-ekf6mja9	1160	14	children	child	NNS
cord-006702-ekf6mja9	1160	15	with	with	IN
cord-006702-ekf6mja9	1160	16	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1160	17	on	on	IN
cord-006702-ekf6mja9	1160	18	regular	regular	JJ
cord-006702-ekf6mja9	1160	19	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	1160	20	.	.	.
cord-006702-ekf6mja9	1161	1	They	-PRON-	PRP
cord-006702-ekf6mja9	1161	2	were	be	VBD
cord-006702-ekf6mja9	1161	3	randomly	randomly	RB
cord-006702-ekf6mja9	1161	4	divided	divide	VBN
cord-006702-ekf6mja9	1161	5	into	into	IN
cord-006702-ekf6mja9	1161	6	3	3	CD
cord-006702-ekf6mja9	1161	7	groups	group	NNS
cord-006702-ekf6mja9	1161	8	:	:	:
cord-006702-ekf6mja9	1162	1	The	the	DT
cord-006702-ekf6mja9	1162	2	first	first	JJ
cord-006702-ekf6mja9	1162	3	group	group	NN
cord-006702-ekf6mja9	1162	4	(	(	-LRB-
cord-006702-ekf6mja9	1162	5	11	11	CD
cord-006702-ekf6mja9	1162	6	cases	case	NNS
cord-006702-ekf6mja9	1162	7	)	)	-RRB-
cord-006702-ekf6mja9	1162	8	on	on	IN
cord-006702-ekf6mja9	1162	9	regular	regular	JJ
cord-006702-ekf6mja9	1162	10	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	1162	11	and	and	CC
cord-006702-ekf6mja9	1162	12	received	receive	VBD
cord-006702-ekf6mja9	1162	13	Cinacalcet	Cinacalcet	NNP
cord-006702-ekf6mja9	1162	14	30mg	30mg	NNP
cord-006702-ekf6mja9	1162	15	/	/	SYM
cord-006702-ekf6mja9	1162	16	day	day	NN
cord-006702-ekf6mja9	1162	17	in	in	IN
cord-006702-ekf6mja9	1162	18	addition	addition	NN
cord-006702-ekf6mja9	1162	19	to	to	IN
cord-006702-ekf6mja9	1162	20	conventional	conventional	JJ
cord-006702-ekf6mja9	1162	21	care	care	NN
cord-006702-ekf6mja9	1162	22	(	(	-LRB-
cord-006702-ekf6mja9	1162	23	vitamin	vitamin	NN
cord-006702-ekf6mja9	1162	24	D	d	NN
cord-006702-ekf6mja9	1162	25	and	and	CC
cord-006702-ekf6mja9	1162	26	phosphorus	phosphorus	NN
cord-006702-ekf6mja9	1162	27	binders	binder	NNS
cord-006702-ekf6mja9	1162	28	)	)	-RRB-
cord-006702-ekf6mja9	1162	29	as	as	IN
cord-006702-ekf6mja9	1162	30	needed	need	VBN
cord-006702-ekf6mja9	1162	31	,	,	,
cord-006702-ekf6mja9	1162	32	the	the	DT
cord-006702-ekf6mja9	1162	33	second	second	JJ
cord-006702-ekf6mja9	1162	34	group	group	NN
cord-006702-ekf6mja9	1162	35	(	(	-LRB-
cord-006702-ekf6mja9	1162	36	13	13	CD
cord-006702-ekf6mja9	1162	37	cases	case	NNS
cord-006702-ekf6mja9	1162	38	)	)	-RRB-
cord-006702-ekf6mja9	1162	39	on	on	IN
cord-006702-ekf6mja9	1162	40	hemodiafiltration	hemodiafiltration	NN
cord-006702-ekf6mja9	1162	41	for	for	IN
cord-006702-ekf6mja9	1162	42	at	at	RB
cord-006702-ekf6mja9	1162	43	least	least	RBS
cord-006702-ekf6mja9	1162	44	6	6	CD
cord-006702-ekf6mja9	1162	45	months	month	NNS
cord-006702-ekf6mja9	1162	46	and	and	CC
cord-006702-ekf6mja9	1162	47	received	receive	VBD
cord-006702-ekf6mja9	1162	48	conventional	conventional	JJ
cord-006702-ekf6mja9	1162	49	care	care	NN
cord-006702-ekf6mja9	1162	50	only	only	RB
cord-006702-ekf6mja9	1162	51	,	,	,
cord-006702-ekf6mja9	1162	52	and	and	CC
cord-006702-ekf6mja9	1162	53	the	the	DT
cord-006702-ekf6mja9	1162	54	third	third	JJ
cord-006702-ekf6mja9	1162	55	group	group	NN
cord-006702-ekf6mja9	1162	56	(	(	-LRB-
cord-006702-ekf6mja9	1162	57	9	9	CD
cord-006702-ekf6mja9	1162	58	cases	case	NNS
cord-006702-ekf6mja9	1162	59	)	)	-RRB-
cord-006702-ekf6mja9	1162	60	[	[	-LRB-
cord-006702-ekf6mja9	1162	61	control	control	NN
cord-006702-ekf6mja9	1162	62	group	group	NN
cord-006702-ekf6mja9	1162	63	]	]	-RRB-
cord-006702-ekf6mja9	1162	64	on	on	IN
cord-006702-ekf6mja9	1162	65	regular	regular	JJ
cord-006702-ekf6mja9	1162	66	hemodialysis	hemodialysis	NN
cord-006702-ekf6mja9	1162	67	received	receive	VBD
cord-006702-ekf6mja9	1162	68	conventional	conventional	JJ
cord-006702-ekf6mja9	1162	69	care	care	NN
cord-006702-ekf6mja9	1162	70	only	only	RB
cord-006702-ekf6mja9	1162	71	.	.	.
cord-006702-ekf6mja9	1163	1	Monthly	monthly	JJ
cord-006702-ekf6mja9	1163	2	follow	follow	VB
cord-006702-ekf6mja9	1163	3	up	up	IN
cord-006702-ekf6mja9	1163	4	of	of	IN
cord-006702-ekf6mja9	1163	5	serum	serum	NN
cord-006702-ekf6mja9	1163	6	calcium	calcium	NN
cord-006702-ekf6mja9	1163	7	,	,	,
cord-006702-ekf6mja9	1163	8	phosphorus	phosphorus	NN
cord-006702-ekf6mja9	1163	9	and	and	CC
cord-006702-ekf6mja9	1163	10	alkaline	alkaline	JJ
cord-006702-ekf6mja9	1163	11	phosphatase	phosphatase	NN
cord-006702-ekf6mja9	1163	12	was	be	VBD
cord-006702-ekf6mja9	1163	13	done	do	VBN
cord-006702-ekf6mja9	1163	14	in	in	IN
cord-006702-ekf6mja9	1163	15	addition	addition	NN
cord-006702-ekf6mja9	1163	16	to	to	IN
cord-006702-ekf6mja9	1163	17	baseline	baseline	NN
cord-006702-ekf6mja9	1163	18	and	and	CC
cord-006702-ekf6mja9	1163	19	3-monthly	3-monthly	CD
cord-006702-ekf6mja9	1163	20	parathormone	parathormone	NN
cord-006702-ekf6mja9	1163	21	level	level	NN
cord-006702-ekf6mja9	1163	22	(	(	-LRB-
cord-006702-ekf6mja9	1163	23	intact	intact	JJ
cord-006702-ekf6mja9	1163	24	PTH	PTH	NNP
cord-006702-ekf6mja9	1163	25	)	)	-RRB-
cord-006702-ekf6mja9	1163	26	.	.	.
cord-006702-ekf6mja9	1164	1	Results	result	NNS
cord-006702-ekf6mja9	1164	2	:	:	:
cord-006702-ekf6mja9	1165	1	The	the	DT
cord-006702-ekf6mja9	1165	2	mean	mean	JJ
cord-006702-ekf6mja9	1165	3	age	age	NN
cord-006702-ekf6mja9	1165	4	of	of	IN
cord-006702-ekf6mja9	1165	5	whole	whole	JJ
cord-006702-ekf6mja9	1165	6	study	study	NN
cord-006702-ekf6mja9	1165	7	population	population	NN
cord-006702-ekf6mja9	1165	8	was	be	VBD
cord-006702-ekf6mja9	1165	9	10.6	10.6	CD
cord-006702-ekf6mja9	1165	10	±	±	CD
cord-006702-ekf6mja9	1165	11	3.9	3.9	CD
cord-006702-ekf6mja9	1165	12	years	year	NNS
cord-006702-ekf6mja9	1165	13	(	(	-LRB-
cord-006702-ekf6mja9	1165	14	range	range	VBP
cord-006702-ekf6mja9	1165	15	3	3	CD
cord-006702-ekf6mja9	1165	16	-17	-17	CD
cord-006702-ekf6mja9	1165	17	years	year	NNS
cord-006702-ekf6mja9	1165	18	)	)	-RRB-
cord-006702-ekf6mja9	1165	19	,	,	,
cord-006702-ekf6mja9	1165	20	and	and	CC
cord-006702-ekf6mja9	1165	21	the	the	DT
cord-006702-ekf6mja9	1165	22	mean	mean	JJ
cord-006702-ekf6mja9	1165	23	weight	weight	NN
cord-006702-ekf6mja9	1165	24	was	be	VBD
cord-006702-ekf6mja9	1165	25	20.2	20.2	CD
cord-006702-ekf6mja9	1165	26	±	±	NNP
cord-006702-ekf6mja9	1165	27	7.3	7.3	CD
cord-006702-ekf6mja9	1165	28	kg	kg	NNS
cord-006702-ekf6mja9	1166	1	(	(	-LRB-
cord-006702-ekf6mja9	1166	2	range	range	NNP
cord-006702-ekf6mja9	1166	3	8	8	CD
cord-006702-ekf6mja9	1166	4	-39.1	-39.1	CD
cord-006702-ekf6mja9	1166	5	kg	kg	CD
cord-006702-ekf6mja9	1166	6	)	)	-RRB-
cord-006702-ekf6mja9	1166	7	.	.	.
cord-006702-ekf6mja9	1167	1	Both	both	DT
cord-006702-ekf6mja9	1167	2	groups	group	NNS
cord-006702-ekf6mja9	1167	3	I	-PRON-	PRP
cord-006702-ekf6mja9	1167	4	&	&	CC
cord-006702-ekf6mja9	1167	5	II	II	NNP
cord-006702-ekf6mja9	1167	6	,	,	,
cord-006702-ekf6mja9	1167	7	but	but	CC
cord-006702-ekf6mja9	1167	8	not	not	RB
cord-006702-ekf6mja9	1167	9	group	group	NN
cord-006702-ekf6mja9	1167	10	III	III	NNP
cord-006702-ekf6mja9	1167	11	,	,	,
cord-006702-ekf6mja9	1167	12	showed	show	VBD
cord-006702-ekf6mja9	1167	13	a	a	DT
cord-006702-ekf6mja9	1167	14	statistically	statistically	RB
cord-006702-ekf6mja9	1167	15	significant	significant	JJ
cord-006702-ekf6mja9	1167	16	increase	increase	NN
cord-006702-ekf6mja9	1167	17	in	in	IN
cord-006702-ekf6mja9	1167	18	HCT	hct	NN
cord-006702-ekf6mja9	1167	19	level	level	NN
cord-006702-ekf6mja9	1167	20	and	and	CC
cord-006702-ekf6mja9	1167	21	a	a	DT
cord-006702-ekf6mja9	1167	22	statistically	statistically	RB
cord-006702-ekf6mja9	1167	23	significant	significant	JJ
cord-006702-ekf6mja9	1167	24	decrease	decrease	NN
cord-006702-ekf6mja9	1167	25	in	in	IN
cord-006702-ekf6mja9	1167	26	ALP	ALP	NNP
cord-006702-ekf6mja9	1167	27	and	and	CC
cord-006702-ekf6mja9	1167	28	PTH	PTH	NNP
cord-006702-ekf6mja9	1167	29	after	after	IN
cord-006702-ekf6mja9	1167	30	the	the	DT
cord-006702-ekf6mja9	1167	31	study	study	NN
cord-006702-ekf6mja9	1167	32	period	period	NN
cord-006702-ekf6mja9	1167	33	.	.	.
cord-006702-ekf6mja9	1168	1	There	there	EX
cord-006702-ekf6mja9	1168	2	was	be	VBD
cord-006702-ekf6mja9	1168	3	a	a	DT
cord-006702-ekf6mja9	1168	4	significant	significant	JJ
cord-006702-ekf6mja9	1168	5	percent	percent	NN
cord-006702-ekf6mja9	1168	6	reduction	reduction	NN
cord-006702-ekf6mja9	1168	7	of	of	IN
cord-006702-ekf6mja9	1168	8	PTH	PTH	NNP
cord-006702-ekf6mja9	1168	9	level	level	NN
cord-006702-ekf6mja9	1168	10	in	in	IN
cord-006702-ekf6mja9	1168	11	group	group	NN
cord-006702-ekf6mja9	1169	1	I	-PRON-	PRP
cord-006702-ekf6mja9	1169	2	patients	patient	NNS
cord-006702-ekf6mja9	1169	3	compared	compare	VBN
cord-006702-ekf6mja9	1169	4	to	to	IN
cord-006702-ekf6mja9	1169	5	those	those	DT
cord-006702-ekf6mja9	1169	6	in	in	IN
cord-006702-ekf6mja9	1169	7	group	group	NN
cord-006702-ekf6mja9	1169	8	III	III	NNP
cord-006702-ekf6mja9	1169	9	.	.	.
cord-006702-ekf6mja9	1170	1	There	there	EX
cord-006702-ekf6mja9	1170	2	was	be	VBD
cord-006702-ekf6mja9	1170	3	no	no	DT
cord-006702-ekf6mja9	1170	4	statistically	statistically	RB
cord-006702-ekf6mja9	1170	5	significnat	significnat	VBN
cord-006702-ekf6mja9	1170	6	difference	difference	NN
cord-006702-ekf6mja9	1170	7	between	between	IN
cord-006702-ekf6mja9	1170	8	percentage	percentage	NN
cord-006702-ekf6mja9	1170	9	of	of	IN
cord-006702-ekf6mja9	1170	10	achievement	achievement	NN
cord-006702-ekf6mja9	1170	11	of	of	IN
cord-006702-ekf6mja9	1170	12	the	the	DT
cord-006702-ekf6mja9	1170	13	NFK	NFK	NNP
cord-006702-ekf6mja9	1170	14	-	-	HYPH
cord-006702-ekf6mja9	1170	15	K	K	NNP
cord-006702-ekf6mja9	1170	16	/	/	SYM
cord-006702-ekf6mja9	1170	17	DOQI	DOQI	NNP
cord-006702-ekf6mja9	1170	18	recommended	recommend	VBD
cord-006702-ekf6mja9	1170	19	goals	goal	NNS
cord-006702-ekf6mja9	1170	20	in	in	IN
cord-006702-ekf6mja9	1170	21	the	the	DT
cord-006702-ekf6mja9	1170	22	three	three	CD
cord-006702-ekf6mja9	1170	23	groups	group	NNS
cord-006702-ekf6mja9	1170	24	.	.	.
cord-006702-ekf6mja9	1171	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1171	2	:	:	:
cord-006702-ekf6mja9	1171	3	in	in	IN
cord-006702-ekf6mja9	1171	4	spite	spite	NN
cord-006702-ekf6mja9	1171	5	of	of	IN
cord-006702-ekf6mja9	1171	6	the	the	DT
cord-006702-ekf6mja9	1171	7	costs	cost	NNS
cord-006702-ekf6mja9	1171	8	of	of	IN
cord-006702-ekf6mja9	1171	9	cinacalcet	cinacalcet	NNS
cord-006702-ekf6mja9	1171	10	and	and	CC
cord-006702-ekf6mja9	1171	11	hemodiafiltration	hemodiafiltration	NN
cord-006702-ekf6mja9	1171	12	,	,	,
cord-006702-ekf6mja9	1171	13	patients	patient	NNS
cord-006702-ekf6mja9	1171	14	with	with	IN
cord-006702-ekf6mja9	1171	15	resistant	resistant	JJ
cord-006702-ekf6mja9	1171	16	hyperparathyroidism	hyperparathyroidism	NN
cord-006702-ekf6mja9	1171	17	should	should	MD
cord-006702-ekf6mja9	1171	18	use	use	VB
cord-006702-ekf6mja9	1171	19	one	one	CD
cord-006702-ekf6mja9	1171	20	of	of	IN
cord-006702-ekf6mja9	1171	21	these	these	DT
cord-006702-ekf6mja9	1171	22	modalities	modality	NNS
cord-006702-ekf6mja9	1171	23	to	to	TO
cord-006702-ekf6mja9	1171	24	avoid	avoid	VB
cord-006702-ekf6mja9	1171	25	complications	complication	NNS
cord-006702-ekf6mja9	1171	26	of	of	IN
cord-006702-ekf6mja9	1171	27	the	the	DT
cord-006702-ekf6mja9	1171	28	metabolic	metabolic	JJ
cord-006702-ekf6mja9	1171	29	bone	bone	NN
cord-006702-ekf6mja9	1171	30	disease	disease	NN
cord-006702-ekf6mja9	1171	31	.	.	.
cord-006702-ekf6mja9	1172	1	The	the	DT
cord-006702-ekf6mja9	1172	2	cost	cost	NN
cord-006702-ekf6mja9	1172	3	of	of	IN
cord-006702-ekf6mja9	1172	4	cinacalcet	cinacalcet	NNS
cord-006702-ekf6mja9	1172	5	and	and	CC
cord-006702-ekf6mja9	1172	6	HDF	HDF	NNP
cord-006702-ekf6mja9	1172	7	should	should	MD
cord-006702-ekf6mja9	1172	8	be	be	VB
cord-006702-ekf6mja9	1172	9	calculated	calculate	VBN
cord-006702-ekf6mja9	1172	10	in	in	IN
cord-006702-ekf6mja9	1172	11	the	the	DT
cord-006702-ekf6mja9	1172	12	context	context	NN
cord-006702-ekf6mja9	1172	13	that	that	IN
cord-006702-ekf6mja9	1172	14	they	-PRON-	PRP
cord-006702-ekf6mja9	1172	15	will	will	MD
cord-006702-ekf6mja9	1172	16	save	save	VB
cord-006702-ekf6mja9	1172	17	in	in	IN
cord-006702-ekf6mja9	1172	18	other	other	JJ
cord-006702-ekf6mja9	1172	19	items	item	NNS
cord-006702-ekf6mja9	1172	20	as	as	IN
cord-006702-ekf6mja9	1172	21	decreasing	decrease	VBG
cord-006702-ekf6mja9	1172	22	the	the	DT
cord-006702-ekf6mja9	1172	23	dose	dose	NN
cord-006702-ekf6mja9	1172	24	of	of	IN
cord-006702-ekf6mja9	1172	25	erythropoietin	erythropoietin	NN
cord-006702-ekf6mja9	1172	26	and	and	CC
cord-006702-ekf6mja9	1172	27	vitamin	vitamin	NN
cord-006702-ekf6mja9	1172	28	D	D	NNP
cord-006702-ekf6mja9	1172	29	analogues	analogue	NNS
cord-006702-ekf6mja9	1172	30	and	and	CC
cord-006702-ekf6mja9	1172	31	decreasing	decrease	VBG
cord-006702-ekf6mja9	1172	32	the	the	DT
cord-006702-ekf6mja9	1172	33	complications	complication	NNS
cord-006702-ekf6mja9	1172	34	,	,	,
cord-006702-ekf6mja9	1172	35	and	and	CC
cord-006702-ekf6mja9	1172	36	consequently	consequently	RB
cord-006702-ekf6mja9	1172	37	therapy	therapy	NN
cord-006702-ekf6mja9	1172	38	,	,	,
cord-006702-ekf6mja9	1172	39	of	of	IN
cord-006702-ekf6mja9	1172	40	bone	bone	NN
cord-006702-ekf6mja9	1172	41	disease	disease	NN
cord-006702-ekf6mja9	1172	42	.	.	.
cord-006702-ekf6mja9	1173	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1173	2	:	:	:
cord-006702-ekf6mja9	1173	3	Vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1173	4	reflux	reflux	NN
cord-006702-ekf6mja9	1173	5	(	(	-LRB-
cord-006702-ekf6mja9	1173	6	VUR	VUR	NNP
cord-006702-ekf6mja9	1173	7	)	)	-RRB-
cord-006702-ekf6mja9	1173	8	is	be	VBZ
cord-006702-ekf6mja9	1173	9	a	a	DT
cord-006702-ekf6mja9	1173	10	common	common	JJ
cord-006702-ekf6mja9	1173	11	urological	urological	JJ
cord-006702-ekf6mja9	1173	12	anomaly	anomaly	NN
cord-006702-ekf6mja9	1173	13	among	among	IN
cord-006702-ekf6mja9	1173	14	children	child	NNS
cord-006702-ekf6mja9	1173	15	.	.	.
cord-006702-ekf6mja9	1174	1	The	the	DT
cord-006702-ekf6mja9	1174	2	genetic	genetic	JJ
cord-006702-ekf6mja9	1174	3	correlations	correlation	NNS
cord-006702-ekf6mja9	1174	4	between	between	IN
cord-006702-ekf6mja9	1174	5	gene	gene	NN
cord-006702-ekf6mja9	1174	6	mutations	mutation	NNS
cord-006702-ekf6mja9	1174	7	and	and	CC
cord-006702-ekf6mja9	1174	8	some	some	DT
cord-006702-ekf6mja9	1174	9	of	of	IN
cord-006702-ekf6mja9	1174	10	the	the	DT
cord-006702-ekf6mja9	1174	11	syndrome	syndrome	NN
cord-006702-ekf6mja9	1174	12	,	,	,
cord-006702-ekf6mja9	1174	13	which	which	WDT
cord-006702-ekf6mja9	1174	14	has	have	VBZ
cord-006702-ekf6mja9	1174	15	VUR	VUR	NNP
cord-006702-ekf6mja9	1174	16	phenotype	phenotype	NN
cord-006702-ekf6mja9	1174	17	,	,	,
cord-006702-ekf6mja9	1174	18	have	have	VBP
cord-006702-ekf6mja9	1174	19	been	be	VBN
cord-006702-ekf6mja9	1174	20	determined	determine	VBN
cord-006702-ekf6mja9	1174	21	in	in	IN
cord-006702-ekf6mja9	1174	22	recent	recent	JJ
cord-006702-ekf6mja9	1174	23	years	year	NNS
cord-006702-ekf6mja9	1174	24	.	.	.
cord-006702-ekf6mja9	1175	1	However	however	RB
cord-006702-ekf6mja9	1175	2	,	,	,
cord-006702-ekf6mja9	1175	3	the	the	DT
cord-006702-ekf6mja9	1175	4	disease	disease	NN
cord-006702-ekf6mja9	1175	5	-	-	HYPH
cord-006702-ekf6mja9	1175	6	causing	cause	VBG
cord-006702-ekf6mja9	1175	7	genes	gene	NNS
cord-006702-ekf6mja9	1175	8	of	of	IN
cord-006702-ekf6mja9	1175	9	isolated	isolated	JJ
cord-006702-ekf6mja9	1175	10	VUR	VUR	NNP
cord-006702-ekf6mja9	1175	11	were	be	VBD
cord-006702-ekf6mja9	1175	12	not	not	RB
cord-006702-ekf6mja9	1175	13	well	well	RB
cord-006702-ekf6mja9	1175	14	understood	understand	VBN
cord-006702-ekf6mja9	1175	15	yet	yet	RB
cord-006702-ekf6mja9	1175	16	.	.	.
cord-006702-ekf6mja9	1176	1	Methods	method	NNS
cord-006702-ekf6mja9	1176	2	:	:	:
cord-006702-ekf6mja9	1176	3	To	to	TO
cord-006702-ekf6mja9	1176	4	determine	determine	VB
cord-006702-ekf6mja9	1176	5	the	the	DT
cord-006702-ekf6mja9	1176	6	disease	disease	NN
cord-006702-ekf6mja9	1176	7	specific	specific	JJ
cord-006702-ekf6mja9	1176	8	genes	gene	NNS
cord-006702-ekf6mja9	1176	9	involving	involve	VBG
cord-006702-ekf6mja9	1176	10	in	in	IN
cord-006702-ekf6mja9	1176	11	isolated	isolated	JJ
cord-006702-ekf6mja9	1176	12	VUR	VUR	NNP
cord-006702-ekf6mja9	1176	13	,	,	,
cord-006702-ekf6mja9	1176	14	the	the	DT
cord-006702-ekf6mja9	1176	15	whole	whole	JJ
cord-006702-ekf6mja9	1176	16	exon	exon	NN
cord-006702-ekf6mja9	1176	17	sequencing	sequencing	NN
cord-006702-ekf6mja9	1176	18	(	(	-LRB-
cord-006702-ekf6mja9	1176	19	WES	WES	NNP
cord-006702-ekf6mja9	1176	20	)	)	-RRB-
cord-006702-ekf6mja9	1176	21	was	be	VBD
cord-006702-ekf6mja9	1176	22	performed	perform	VBN
cord-006702-ekf6mja9	1176	23	in	in	IN
cord-006702-ekf6mja9	1176	24	37	37	CD
cord-006702-ekf6mja9	1176	25	VUR	VUR	NNP
cord-006702-ekf6mja9	1176	26	patients	patient	NNS
cord-006702-ekf6mja9	1176	27	.	.	.
cord-006702-ekf6mja9	1177	1	Of	of	IN
cord-006702-ekf6mja9	1177	2	these	these	DT
cord-006702-ekf6mja9	1177	3	37	37	CD
cord-006702-ekf6mja9	1177	4	patients	patient	NNS
cord-006702-ekf6mja9	1177	5	,	,	,
cord-006702-ekf6mja9	1177	6	28	28	CD
cord-006702-ekf6mja9	1177	7	were	be	VBD
cord-006702-ekf6mja9	1177	8	isolated	isolate	VBN
cord-006702-ekf6mja9	1178	1	VUR.Exon	VUR.Exon	NNP
cord-006702-ekf6mja9	1178	2	-	-	HYPH
cord-006702-ekf6mja9	1178	3	enriched	enrich	VBN
cord-006702-ekf6mja9	1178	4	DNA	dna	NN
cord-006702-ekf6mja9	1178	5	was	be	VBD
cord-006702-ekf6mja9	1178	6	sequenced	sequence	VBN
cord-006702-ekf6mja9	1178	7	by	by	IN
cord-006702-ekf6mja9	1178	8	the	the	DT
cord-006702-ekf6mja9	1178	9	Illumina	Illumina	NNP
cord-006702-ekf6mja9	1178	10	hiseq2500	hiseq2500	NNP
cord-006702-ekf6mja9	1178	11	platform	platform	NN
cord-006702-ekf6mja9	1178	12	following	follow	VBG
cord-006702-ekf6mja9	1178	13	the	the	DT
cord-006702-ekf6mja9	1178	14	manufacturer	manufacturer	NN
cord-006702-ekf6mja9	1178	15	's	's	POS
cord-006702-ekf6mja9	1178	16	instructions	instruction	NNS
cord-006702-ekf6mja9	1178	17	(	(	-LRB-
cord-006702-ekf6mja9	1178	18	Illumina	Illumina	NNP
cord-006702-ekf6mja9	1178	19	)	)	-RRB-
cord-006702-ekf6mja9	1178	20	.	.	.
cord-006702-ekf6mja9	1179	1	Results	result	NNS
cord-006702-ekf6mja9	1179	2	:	:	:
cord-006702-ekf6mja9	1180	1	WES	WES	NNP
cord-006702-ekf6mja9	1180	2	data	datum	NNS
cord-006702-ekf6mja9	1180	3	shows	show	VBZ
cord-006702-ekf6mja9	1180	4	74	74	CD
cord-006702-ekf6mja9	1180	5	mutations	mutation	NNS
cord-006702-ekf6mja9	1180	6	(	(	-LRB-
cord-006702-ekf6mja9	1180	7	69	69	CD
cord-006702-ekf6mja9	1180	8	novel	novel	NN
cord-006702-ekf6mja9	1180	9	)	)	-RRB-
cord-006702-ekf6mja9	1180	10	in	in	IN
cord-006702-ekf6mja9	1180	11	28	28	CD
cord-006702-ekf6mja9	1180	12	genes	gene	NNS
cord-006702-ekf6mja9	1180	13	in	in	IN
cord-006702-ekf6mja9	1180	14	32	32	CD
cord-006702-ekf6mja9	1180	15	patients	patient	NNS
cord-006702-ekf6mja9	1180	16	(	(	-LRB-
cord-006702-ekf6mja9	1180	17	86.5	86.5	CD
cord-006702-ekf6mja9	1180	18	%	%	NN
cord-006702-ekf6mja9	1180	19	)	)	-RRB-
cord-006702-ekf6mja9	1180	20	from	from	IN
cord-006702-ekf6mja9	1180	21	37	37	CD
cord-006702-ekf6mja9	1180	22	families	family	NNS
cord-006702-ekf6mja9	1180	23	(	(	-LRB-
cord-006702-ekf6mja9	1180	24	Table	table	NN
cord-006702-ekf6mja9	1180	25	1	1	CD
cord-006702-ekf6mja9	1180	26	)	)	-RRB-
cord-006702-ekf6mja9	1180	27	.	.	.
cord-006702-ekf6mja9	1181	1	These	these	DT
cord-006702-ekf6mja9	1181	2	genes	gene	NNS
cord-006702-ekf6mja9	1181	3	include	include	VBP
cord-006702-ekf6mja9	1181	4	(	(	-LRB-
cord-006702-ekf6mja9	1181	5	number	number	NN
cord-006702-ekf6mja9	1181	6	of	of	IN
cord-006702-ekf6mja9	1181	7	mutations	mutation	NNS
cord-006702-ekf6mja9	1181	8	)	)	-RRB-
cord-006702-ekf6mja9	1181	9	:	:	:
cord-006702-ekf6mja9	1182	1	TNXB	TNXB	NNP
cord-006702-ekf6mja9	1182	2	(	(	-LRB-
cord-006702-ekf6mja9	1182	3	12	12	CD
cord-006702-ekf6mja9	1182	4	)	)	-RRB-
cord-006702-ekf6mja9	1182	5	,	,	,
cord-006702-ekf6mja9	1182	6	TRAP1	TRAP1	NNP
cord-006702-ekf6mja9	1182	7	(	(	-LRB-
cord-006702-ekf6mja9	1182	8	7	7	CD
cord-006702-ekf6mja9	1182	9	)	)	-RRB-
cord-006702-ekf6mja9	1182	10	,	,	,
cord-006702-ekf6mja9	1182	11	KANSL1	KANSL1	NNP
cord-006702-ekf6mja9	1182	12	(	(	-LRB-
cord-006702-ekf6mja9	1182	13	6	6	CD
cord-006702-ekf6mja9	1182	14	)	)	-RRB-
cord-006702-ekf6mja9	1182	15	,	,	,
cord-006702-ekf6mja9	1182	16	RET	RET	NNP
cord-006702-ekf6mja9	1182	17	(	(	-LRB-
cord-006702-ekf6mja9	1182	18	6	6	CD
cord-006702-ekf6mja9	1182	19	)	)	-RRB-
cord-006702-ekf6mja9	1182	20	,	,	,
cord-006702-ekf6mja9	1182	21	ROBO2	ROBO2	NNP
cord-006702-ekf6mja9	1182	22	(	(	-LRB-
cord-006702-ekf6mja9	1182	23	6	6	CD
cord-006702-ekf6mja9	1182	24	)	)	-RRB-
cord-006702-ekf6mja9	1182	25	,	,	,
cord-006702-ekf6mja9	1182	26	UPK3A	UPK3A	NNP
cord-006702-ekf6mja9	1182	27	(	(	-LRB-
cord-006702-ekf6mja9	1182	28	4	4	CD
cord-006702-ekf6mja9	1182	29	)	)	-RRB-
cord-006702-ekf6mja9	1182	30	,	,	,
cord-006702-ekf6mja9	1182	31	GENE	GENE	NNP
cord-006702-ekf6mja9	1182	32	1(4	1(4	CD
cord-006702-ekf6mja9	1182	33	)	)	-RRB-
cord-006702-ekf6mja9	1182	34	,	,	,
cord-006702-ekf6mja9	1182	35	XRN1	XRN1	NNP
cord-006702-ekf6mja9	1182	36	(	(	-LRB-
cord-006702-ekf6mja9	1182	37	3	3	CD
cord-006702-ekf6mja9	1182	38	)	)	-RRB-
cord-006702-ekf6mja9	1182	39	,	,	,
cord-006702-ekf6mja9	1182	40	SALL1	SALL1	NNP
cord-006702-ekf6mja9	1182	41	(	(	-LRB-
cord-006702-ekf6mja9	1182	42	3	3	CD
cord-006702-ekf6mja9	1182	43	)	)	-RRB-
cord-006702-ekf6mja9	1182	44	,	,	,
cord-006702-ekf6mja9	1182	45	SALL4	SALL4	NNP
cord-006702-ekf6mja9	1182	46	(	(	-LRB-
cord-006702-ekf6mja9	1182	47	3	3	LS
cord-006702-ekf6mja9	1182	48	)	)	-RRB-
cord-006702-ekf6mja9	1182	49	,	,	,
cord-006702-ekf6mja9	1182	50	BICC1	BICC1	NNP
cord-006702-ekf6mja9	1182	51	(	(	-LRB-
cord-006702-ekf6mja9	1182	52	2	2	CD
cord-006702-ekf6mja9	1182	53	)	)	-RRB-
cord-006702-ekf6mja9	1182	54	,	,	,
cord-006702-ekf6mja9	1182	55	EYA1	EYA1	NNP
cord-006702-ekf6mja9	1182	56	(	(	-LRB-
cord-006702-ekf6mja9	1182	57	2	2	CD
cord-006702-ekf6mja9	1182	58	)	)	-RRB-
cord-006702-ekf6mja9	1182	59	,	,	,
cord-006702-ekf6mja9	1182	60	and	and	CC
cord-006702-ekf6mja9	1182	61	other	other	JJ
cord-006702-ekf6mja9	1182	62	16	16	CD
cord-006702-ekf6mja9	1182	63	genes	gene	NNS
cord-006702-ekf6mja9	1182	64	shows	show	VBZ
cord-006702-ekf6mja9	1182	65	one	one	CD
cord-006702-ekf6mja9	1182	66	mutation	mutation	NN
cord-006702-ekf6mja9	1182	67	.	.	.
cord-006702-ekf6mja9	1183	1	Several	several	JJ
cord-006702-ekf6mja9	1183	2	mutations	mutation	NNS
cord-006702-ekf6mja9	1183	3	of	of	IN
cord-006702-ekf6mja9	1183	4	RET	ret	NN
cord-006702-ekf6mja9	1183	5	and	and	CC
cord-006702-ekf6mja9	1183	6	HNF1B	hnf1b	NN
cord-006702-ekf6mja9	1183	7	genes	gene	NNS
cord-006702-ekf6mja9	1183	8	consistent	consistent	JJ
cord-006702-ekf6mja9	1183	9	with	with	IN
cord-006702-ekf6mja9	1183	10	previously	previously	RB
cord-006702-ekf6mja9	1183	11	investigation	investigation	NN
cord-006702-ekf6mja9	1183	12	.	.	.
cord-006702-ekf6mja9	1184	1	Further	further	JJ
cord-006702-ekf6mja9	1184	2	analysis	analysis	NN
cord-006702-ekf6mja9	1184	3	by	by	IN
cord-006702-ekf6mja9	1184	4	perniciousness	perniciousness	NNP
cord-006702-ekf6mja9	1184	5	of	of	IN
cord-006702-ekf6mja9	1184	6	mutation	mutation	NN
cord-006702-ekf6mja9	1184	7	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	1184	8	that	that	IN
cord-006702-ekf6mja9	1184	9	the	the	DT
cord-006702-ekf6mja9	1184	10	mutation	mutation	NN
cord-006702-ekf6mja9	1184	11	of	of	IN
cord-006702-ekf6mja9	1184	12	TNXB	TNXB	NNP
cord-006702-ekf6mja9	1184	13	is	be	VBZ
cord-006702-ekf6mja9	1184	14	significantly	significantly	RB
cord-006702-ekf6mja9	1184	15	correlated	correlate	VBN
cord-006702-ekf6mja9	1184	16	with	with	IN
cord-006702-ekf6mja9	1184	17	VUR	VUR	NNP
cord-006702-ekf6mja9	1184	18	risk	risk	NN
cord-006702-ekf6mja9	1184	19	stratification	stratification	NN
cord-006702-ekf6mja9	1184	20	.	.	.
cord-006702-ekf6mja9	1185	1	The	the	DT
cord-006702-ekf6mja9	1185	2	staging	staging	NN
cord-006702-ekf6mja9	1185	3	of	of	IN
cord-006702-ekf6mja9	1185	4	VUR	VUR	NNP
cord-006702-ekf6mja9	1185	5	of	of	IN
cord-006702-ekf6mja9	1185	6	patient	patient	NN
cord-006702-ekf6mja9	1185	7	harboring	harbor	VBG
cord-006702-ekf6mja9	1185	8	4	4	CD
cord-006702-ekf6mja9	1185	9	or	or	CC
cord-006702-ekf6mja9	1185	10	above	above	IN
cord-006702-ekf6mja9	1185	11	mutations	mutation	NNS
cord-006702-ekf6mja9	1185	12	is	be	VBZ
cord-006702-ekf6mja9	1185	13	much	much	RB
cord-006702-ekf6mja9	1185	14	higher	high	JJR
cord-006702-ekf6mja9	1185	15	than	than	IN
cord-006702-ekf6mja9	1185	16	the	the	DT
cord-006702-ekf6mja9	1185	17	patient	patient	NN
cord-006702-ekf6mja9	1185	18	harboring	harbor	VBG
cord-006702-ekf6mja9	1185	19	4	4	CD
cord-006702-ekf6mja9	1185	20	or	or	CC
cord-006702-ekf6mja9	1185	21	bellowed	bellow	VBN
cord-006702-ekf6mja9	1185	22	(	(	-LRB-
cord-006702-ekf6mja9	1185	23	OR	or	CC
cord-006702-ekf6mja9	1185	24	score	score	NN
cord-006702-ekf6mja9	1185	25	is	be	VBZ
cord-006702-ekf6mja9	1185	26	4	4	CD
cord-006702-ekf6mja9	1185	27	)	)	-RRB-
cord-006702-ekf6mja9	1186	1	(	(	-LRB-
cord-006702-ekf6mja9	1186	2	Table	table	NN
cord-006702-ekf6mja9	1186	3	2	2	CD
cord-006702-ekf6mja9	1186	4	)	)	-RRB-
cord-006702-ekf6mja9	1186	5	.	.	.
cord-006702-ekf6mja9	1187	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	1187	2	findings	finding	NNS
cord-006702-ekf6mja9	1187	3	may	may	MD
cord-006702-ekf6mja9	1187	4	provide	provide	VB
cord-006702-ekf6mja9	1187	5	a	a	DT
cord-006702-ekf6mja9	1187	6	clinical	clinical	JJ
cord-006702-ekf6mja9	1187	7	molecular	molecular	JJ
cord-006702-ekf6mja9	1187	8	marker	marker	NN
cord-006702-ekf6mja9	1187	9	in	in	IN
cord-006702-ekf6mja9	1187	10	VUR	VUR	NNP
cord-006702-ekf6mja9	1187	11	for	for	IN
cord-006702-ekf6mja9	1187	12	risk	risk	NN
cord-006702-ekf6mja9	1187	13	stratification	stratification	NN
cord-006702-ekf6mja9	1187	14	.	.	.
cord-006702-ekf6mja9	1188	1	Finally	finally	RB
cord-006702-ekf6mja9	1188	2	,	,	,
cord-006702-ekf6mja9	1188	3	it	-PRON-	PRP
cord-006702-ekf6mja9	1188	4	is	be	VBZ
cord-006702-ekf6mja9	1188	5	reported	report	VBN
cord-006702-ekf6mja9	1188	6	that	that	IN
cord-006702-ekf6mja9	1188	7	C5orf49	C5orf49	NNP
cord-006702-ekf6mja9	1188	8	mutation	mutation	NN
cord-006702-ekf6mja9	1188	9	could	could	MD
cord-006702-ekf6mja9	1188	10	cause	cause	VB
cord-006702-ekf6mja9	1188	11	Meckel	Meckel	NNP
cord-006702-ekf6mja9	1188	12	-	-	HYPH
cord-006702-ekf6mja9	1188	13	Gruber	Gruber	NNP
cord-006702-ekf6mja9	1188	14	Syndrome	Syndrome	NNP
cord-006702-ekf6mja9	1188	15	.	.	.
cord-006702-ekf6mja9	1189	1	In	in	IN
cord-006702-ekf6mja9	1189	2	present	present	JJ
cord-006702-ekf6mja9	1189	3	study	study	NN
cord-006702-ekf6mja9	1189	4	,	,	,
cord-006702-ekf6mja9	1189	5	we	-PRON-	PRP
cord-006702-ekf6mja9	1189	6	identified	identify	VBD
cord-006702-ekf6mja9	1189	7	a	a	DT
cord-006702-ekf6mja9	1189	8	run	run	NN
cord-006702-ekf6mja9	1189	9	-	-	HYPH
cord-006702-ekf6mja9	1189	10	on	on	RP
cord-006702-ekf6mja9	1189	11	mutation	mutation	NN
cord-006702-ekf6mja9	1189	12	were	be	VBD
cord-006702-ekf6mja9	1189	13	shared	share	VBN
cord-006702-ekf6mja9	1189	14	by	by	IN
cord-006702-ekf6mja9	1189	15	5	5	CD
cord-006702-ekf6mja9	1189	16	VUR	VUR	NNP
cord-006702-ekf6mja9	1189	17	patients	patient	NNS
cord-006702-ekf6mja9	1189	18	out	out	IN
cord-006702-ekf6mja9	1189	19	of	of	IN
cord-006702-ekf6mja9	1189	20	the	the	DT
cord-006702-ekf6mja9	1189	21	37	37	CD
cord-006702-ekf6mja9	1189	22	patients	patient	NNS
cord-006702-ekf6mja9	1189	23	.	.	.
cord-006702-ekf6mja9	1190	1	Although	although	IN
cord-006702-ekf6mja9	1190	2	the	the	DT
cord-006702-ekf6mja9	1190	3	MAF	MAF	NNP
cord-006702-ekf6mja9	1190	4	in	in	IN
cord-006702-ekf6mja9	1190	5	Chinese	chinese	JJ
cord-006702-ekf6mja9	1190	6	thousand	thousand	CD
cord-006702-ekf6mja9	1190	7	-	-	HYPH
cord-006702-ekf6mja9	1190	8	genome	genome	NN
cord-006702-ekf6mja9	1190	9	project	project	NN
cord-006702-ekf6mja9	1190	10	is	be	VBZ
cord-006702-ekf6mja9	1190	11	around	around	IN
cord-006702-ekf6mja9	1190	12	4.7	4.7	CD
cord-006702-ekf6mja9	1190	13	%	%	NN
cord-006702-ekf6mja9	1190	14	,	,	,
cord-006702-ekf6mja9	1190	15	much	much	RB
cord-006702-ekf6mja9	1190	16	higher	high	JJR
cord-006702-ekf6mja9	1190	17	than	than	IN
cord-006702-ekf6mja9	1190	18	western	western	JJ
cord-006702-ekf6mja9	1190	19	population	population	NN
cord-006702-ekf6mja9	1190	20	,	,	,
cord-006702-ekf6mja9	1190	21	it	-PRON-	PRP
cord-006702-ekf6mja9	1190	22	may	may	MD
cord-006702-ekf6mja9	1190	23	be	be	VB
cord-006702-ekf6mja9	1190	24	a	a	DT
cord-006702-ekf6mja9	1190	25	susceptibility	susceptibility	NN
cord-006702-ekf6mja9	1190	26	gene	gene	NN
cord-006702-ekf6mja9	1190	27	candidate	candidate	NN
cord-006702-ekf6mja9	1190	28	in	in	IN
cord-006702-ekf6mja9	1190	29	Chinese	chinese	JJ
cord-006702-ekf6mja9	1190	30	population	population	NN
cord-006702-ekf6mja9	1190	31	,	,	,
cord-006702-ekf6mja9	1190	32	which	which	WDT
cord-006702-ekf6mja9	1190	33	needs	need	VBZ
cord-006702-ekf6mja9	1190	34	to	to	TO
cord-006702-ekf6mja9	1190	35	be	be	VB
cord-006702-ekf6mja9	1190	36	validated	validate	VBN
cord-006702-ekf6mja9	1190	37	in	in	IN
cord-006702-ekf6mja9	1190	38	a	a	DT
cord-006702-ekf6mja9	1190	39	larger	large	JJR
cord-006702-ekf6mja9	1190	40	sample	sample	NN
cord-006702-ekf6mja9	1190	41	size	size	NN
cord-006702-ekf6mja9	1190	42	.	.	.
cord-006702-ekf6mja9	1191	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1191	2	:	:	:
cord-006702-ekf6mja9	1192	1	Our	-PRON-	PRP$
cord-006702-ekf6mja9	1192	2	data	datum	NNS
cord-006702-ekf6mja9	1192	3	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	1192	4	that	that	IN
cord-006702-ekf6mja9	1192	5	the	the	DT
cord-006702-ekf6mja9	1192	6	whole	whole	JJ
cord-006702-ekf6mja9	1192	7	exon	exon	NN
cord-006702-ekf6mja9	1192	8	sequencing	sequencing	NN
cord-006702-ekf6mja9	1192	9	is	be	VBZ
cord-006702-ekf6mja9	1192	10	a	a	DT
cord-006702-ekf6mja9	1192	11	reliable	reliable	JJ
cord-006702-ekf6mja9	1192	12	approach	approach	NN
cord-006702-ekf6mja9	1192	13	to	to	TO
cord-006702-ekf6mja9	1192	14	identify	identify	VB
cord-006702-ekf6mja9	1192	15	disease	disease	NN
cord-006702-ekf6mja9	1192	16	-	-	HYPH
cord-006702-ekf6mja9	1192	17	causing	cause	VBG
cord-006702-ekf6mja9	1192	18	genes	gene	NNS
cord-006702-ekf6mja9	1192	19	in	in	IN
cord-006702-ekf6mja9	1192	20	isolated	isolate	VBN
cord-006702-ekf6mja9	1192	21	VUR	VUR	NNP
cord-006702-ekf6mja9	1192	22	,	,	,
cord-006702-ekf6mja9	1192	23	and	and	CC
cord-006702-ekf6mja9	1192	24	C5orf49	C5orf49	NNP
cord-006702-ekf6mja9	1192	25	may	may	MD
cord-006702-ekf6mja9	1192	26	involve	involve	VB
cord-006702-ekf6mja9	1192	27	in	in	IN
cord-006702-ekf6mja9	1192	28	the	the	DT
cord-006702-ekf6mja9	1192	29	VUR	VUR	NNP
cord-006702-ekf6mja9	1192	30	pathogenesis	pathogenesis	NN
cord-006702-ekf6mja9	1192	31	.	.	.
cord-006702-ekf6mja9	1193	1	FP	FP	NNP
cord-006702-ekf6mja9	1193	2	-	-	HYPH
cord-006702-ekf6mja9	1193	3	S32	S32	NNP
cord-006702-ekf6mja9	1193	4	-	-	HYPH
cord-006702-ekf6mja9	1193	5	2	2	CD
cord-006702-ekf6mja9	1194	1	A	a	DT
cord-006702-ekf6mja9	1194	2	cost	cost	NN
cord-006702-ekf6mja9	1194	3	-	-	HYPH
cord-006702-ekf6mja9	1194	4	consequence	consequence	NN
cord-006702-ekf6mja9	1194	5	analysis	analysis	NN
cord-006702-ekf6mja9	1194	6	of	of	IN
cord-006702-ekf6mja9	1194	7	treatment	treatment	NN
cord-006702-ekf6mja9	1194	8	of	of	IN
cord-006702-ekf6mja9	1194	9	vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1194	10	reflux	reflux	NN
cord-006702-ekf6mja9	1194	11	(	(	-LRB-
cord-006702-ekf6mja9	1194	12	VUR	VUR	NNP
cord-006702-ekf6mja9	1194	13	)	)	-RRB-
cord-006702-ekf6mja9	1194	14	:	:	:
cord-006702-ekf6mja9	1194	15	Which	which	WDT
cord-006702-ekf6mja9	1194	16	children	child	NNS
cord-006702-ekf6mja9	1194	17	benefit	benefit	VBP
cord-006702-ekf6mja9	1194	18	from	from	IN
cord-006702-ekf6mja9	1194	19	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1194	20	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1194	21	?	?	.
cord-006702-ekf6mja9	1195	1	N.	N.	NNP
cord-006702-ekf6mja9	1195	2	Shaikh	Shaikh	NNP
cord-006702-ekf6mja9	1195	3	(	(	-LRB-
cord-006702-ekf6mja9	1195	4	1	1	CD
cord-006702-ekf6mja9	1195	5	)	)	-RRB-
cord-006702-ekf6mja9	1195	6	,	,	,
cord-006702-ekf6mja9	1195	7	V.	V.	NNP
cord-006702-ekf6mja9	1195	8	Rajakumar	Rajakumar	NNP
cord-006702-ekf6mja9	1195	9	(	(	-LRB-
cord-006702-ekf6mja9	1195	10	1	1	CD
cord-006702-ekf6mja9	1195	11	)	)	-RRB-
cord-006702-ekf6mja9	1195	12	,	,	,
cord-006702-ekf6mja9	1195	13	J.	J.	NNP
cord-006702-ekf6mja9	1195	14	Gorski	Gorski	NNP
cord-006702-ekf6mja9	1195	15	(	(	-LRB-
cord-006702-ekf6mja9	1195	16	2	2	CD
cord-006702-ekf6mja9	1195	17	)	)	-RRB-
cord-006702-ekf6mja9	1196	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1196	2	:	:	:
cord-006702-ekf6mja9	1196	3	Antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1196	4	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1196	5	for	for	IN
cord-006702-ekf6mja9	1196	6	children	child	NNS
cord-006702-ekf6mja9	1196	7	with	with	IN
cord-006702-ekf6mja9	1196	8	VUR	VUR	NNP
cord-006702-ekf6mja9	1196	9	reduces	reduce	VBZ
cord-006702-ekf6mja9	1196	10	the	the	DT
cord-006702-ekf6mja9	1196	11	risk	risk	NN
cord-006702-ekf6mja9	1196	12	of	of	IN
cord-006702-ekf6mja9	1196	13	recurrences	recurrence	NNS
cord-006702-ekf6mja9	1196	14	of	of	IN
cord-006702-ekf6mja9	1196	15	UTI	UTI	NNP
cord-006702-ekf6mja9	1196	16	,	,	,
cord-006702-ekf6mja9	1196	17	but	but	CC
cord-006702-ekf6mja9	1196	18	requires	require	VBZ
cord-006702-ekf6mja9	1196	19	daily	daily	JJ
cord-006702-ekf6mja9	1196	20	administration	administration	NN
cord-006702-ekf6mja9	1196	21	of	of	IN
cord-006702-ekf6mja9	1196	22	an	an	DT
cord-006702-ekf6mja9	1196	23	antimicrobial	antimicrobial	NN
cord-006702-ekf6mja9	1196	24	for	for	IN
cord-006702-ekf6mja9	1196	25	extended	extended	JJ
cord-006702-ekf6mja9	1196	26	periods	period	NNS
cord-006702-ekf6mja9	1196	27	.	.	.
cord-006702-ekf6mja9	1197	1	Repeated	repeat	VBN
cord-006702-ekf6mja9	1197	2	UTIs	uti	NNS
cord-006702-ekf6mja9	1197	3	can	can	MD
cord-006702-ekf6mja9	1197	4	rarely	rarely	RB
cord-006702-ekf6mja9	1197	5	lead	lead	VB
cord-006702-ekf6mja9	1197	6	to	to	IN
cord-006702-ekf6mja9	1197	7	long	long	JJ
cord-006702-ekf6mja9	1197	8	-	-	HYPH
cord-006702-ekf6mja9	1197	9	term	term	NN
cord-006702-ekf6mja9	1197	10	consequences	consequence	NNS
cord-006702-ekf6mja9	1197	11	such	such	JJ
cord-006702-ekf6mja9	1197	12	as	as	IN
cord-006702-ekf6mja9	1197	13	hypertension	hypertension	NN
cord-006702-ekf6mja9	1197	14	,	,	,
cord-006702-ekf6mja9	1197	15	preeclampsia	preeclampsia	NN
cord-006702-ekf6mja9	1197	16	,	,	,
cord-006702-ekf6mja9	1197	17	and	and	CC
cord-006702-ekf6mja9	1197	18	end	end	NN
cord-006702-ekf6mja9	1197	19	stage	stage	NN
cord-006702-ekf6mja9	1197	20	renal	renal	JJ
cord-006702-ekf6mja9	1197	21	disease	disease	NN
cord-006702-ekf6mja9	1197	22	.	.	.
cord-006702-ekf6mja9	1198	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1198	2	used	use	VBD
cord-006702-ekf6mja9	1198	3	a	a	DT
cord-006702-ekf6mja9	1198	4	cost	cost	NN
cord-006702-ekf6mja9	1198	5	-	-	HYPH
cord-006702-ekf6mja9	1198	6	consequence	consequence	NN
cord-006702-ekf6mja9	1198	7	model	model	NN
cord-006702-ekf6mja9	1198	8	to	to	TO
cord-006702-ekf6mja9	1198	9	evaluate	evaluate	VB
cord-006702-ekf6mja9	1198	10	whether	whether	IN
cord-006702-ekf6mja9	1198	11	the	the	DT
cord-006702-ekf6mja9	1198	12	benefits	benefit	NNS
cord-006702-ekf6mja9	1198	13	of	of	IN
cord-006702-ekf6mja9	1198	14	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1198	15	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1198	16	outweigh	outweigh	VBP
cord-006702-ekf6mja9	1198	17	its	-PRON-	PRP$
cord-006702-ekf6mja9	1198	18	risks	risk	NNS
cord-006702-ekf6mja9	1198	19	,	,	,
cord-006702-ekf6mja9	1198	20	and	and	CC
cord-006702-ekf6mja9	1198	21	if	if	IN
cord-006702-ekf6mja9	1198	22	so	so	RB
cord-006702-ekf6mja9	1198	23	for	for	IN
cord-006702-ekf6mja9	1198	24	which	which	WDT
cord-006702-ekf6mja9	1198	25	subgroups	subgroup	NNS
cord-006702-ekf6mja9	1198	26	of	of	IN
cord-006702-ekf6mja9	1198	27	children	child	NNS
cord-006702-ekf6mja9	1198	28	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1198	29	may	may	MD
cord-006702-ekf6mja9	1198	30	not	not	RB
cord-006702-ekf6mja9	1198	31	be	be	VB
cord-006702-ekf6mja9	1198	32	cost	cost	NN
cord-006702-ekf6mja9	1198	33	-	-	HYPH
cord-006702-ekf6mja9	1198	34	effective	effective	JJ
cord-006702-ekf6mja9	1198	35	.	.	.
cord-006702-ekf6mja9	1199	1	Methods	method	NNS
cord-006702-ekf6mja9	1199	2	:	:	:
cord-006702-ekf6mja9	1200	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1200	2	compared	compare	VBD
cord-006702-ekf6mja9	1200	3	the	the	DT
cord-006702-ekf6mja9	1200	4	costs	cost	NNS
cord-006702-ekf6mja9	1200	5	and	and	CC
cord-006702-ekf6mja9	1200	6	consequences	consequence	NNS
cord-006702-ekf6mja9	1200	7	of	of	IN
cord-006702-ekf6mja9	1200	8	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1200	9	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1200	10	with	with	IN
cord-006702-ekf6mja9	1200	11	trimethoprim	trimethoprim	NNP
cord-006702-ekf6mja9	1200	12	-	-	HYPH
cord-006702-ekf6mja9	1200	13	sulfamethoxazole	sulfamethoxazole	NNP
cord-006702-ekf6mja9	1200	14	to	to	IN
cord-006702-ekf6mja9	1200	15	no	no	DT
cord-006702-ekf6mja9	1200	16	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1200	17	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1200	18	in	in	IN
cord-006702-ekf6mja9	1200	19	children	child	NNS
cord-006702-ekf6mja9	1200	20	aged	age	VBN
cord-006702-ekf6mja9	1200	21	<	<	XX
cord-006702-ekf6mja9	1200	22	6	6	CD
cord-006702-ekf6mja9	1200	23	years	year	NNS
cord-006702-ekf6mja9	1200	24	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	1200	25	with	with	IN
cord-006702-ekf6mja9	1200	26	VUR	VUR	NNP
cord-006702-ekf6mja9	1200	27	grades	grade	NNS
cord-006702-ekf6mja9	1200	28	I	I	NNP
cord-006702-ekf6mja9	1200	29	-	-	HYPH
cord-006702-ekf6mja9	1200	30	IV	IV	NNP
cord-006702-ekf6mja9	1200	31	after	after	IN
cord-006702-ekf6mja9	1200	32	a	a	DT
cord-006702-ekf6mja9	1200	33	first	first	JJ
cord-006702-ekf6mja9	1200	34	or	or	CC
cord-006702-ekf6mja9	1200	35	second	second	JJ
cord-006702-ekf6mja9	1200	36	UTI	UTI	NNP
cord-006702-ekf6mja9	1200	37	.	.	.
cord-006702-ekf6mja9	1201	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1201	2	also	also	RB
cord-006702-ekf6mja9	1201	3	examined	examine	VBD
cord-006702-ekf6mja9	1201	4	the	the	DT
cord-006702-ekf6mja9	1201	5	results	result	NNS
cord-006702-ekf6mja9	1201	6	in	in	IN
cord-006702-ekf6mja9	1201	7	subgroups	subgroup	NNS
cord-006702-ekf6mja9	1201	8	defined	define	VBN
cord-006702-ekf6mja9	1201	9	by	by	IN
cord-006702-ekf6mja9	1201	10	grade	grade	NN
cord-006702-ekf6mja9	1201	11	of	of	IN
cord-006702-ekf6mja9	1201	12	VUR	VUR	NNP
cord-006702-ekf6mja9	1201	13	,	,	,
cord-006702-ekf6mja9	1201	14	presence	presence	NN
cord-006702-ekf6mja9	1201	15	of	of	IN
cord-006702-ekf6mja9	1201	16	bladder	bladder	NN
cord-006702-ekf6mja9	1201	17	bowel	bowel	NN
cord-006702-ekf6mja9	1201	18	dysfunction	dysfunction	NN
cord-006702-ekf6mja9	1201	19	(	(	-LRB-
cord-006702-ekf6mja9	1201	20	BBD	BBD	NNP
cord-006702-ekf6mja9	1201	21	)	)	-RRB-
cord-006702-ekf6mja9	1201	22	,	,	,
cord-006702-ekf6mja9	1201	23	and	and	CC
cord-006702-ekf6mja9	1201	24	presence	presence	NN
cord-006702-ekf6mja9	1201	25	of	of	IN
cord-006702-ekf6mja9	1201	26	fever	fever	NN
cord-006702-ekf6mja9	1201	27	at	at	IN
cord-006702-ekf6mja9	1201	28	the	the	DT
cord-006702-ekf6mja9	1201	29	time	time	NN
cord-006702-ekf6mja9	1201	30	of	of	IN
cord-006702-ekf6mja9	1201	31	UTI	UTI	NNP
cord-006702-ekf6mja9	1201	32	.	.	.
cord-006702-ekf6mja9	1202	1	Costs	cost	NNS
cord-006702-ekf6mja9	1202	2	and	and	CC
cord-006702-ekf6mja9	1202	3	consequences	consequence	NNS
cord-006702-ekf6mja9	1202	4	were	be	VBD
cord-006702-ekf6mja9	1202	5	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1202	6	over	over	IN
cord-006702-ekf6mja9	1202	7	the	the	DT
cord-006702-ekf6mja9	1202	8	patient	patient	NN
cord-006702-ekf6mja9	1202	9	's	's	POS
cord-006702-ekf6mja9	1202	10	lifetime	lifetime	NN
cord-006702-ekf6mja9	1202	11	.	.	.
cord-006702-ekf6mja9	1203	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1203	2	included	include	VBD
cord-006702-ekf6mja9	1203	3	the	the	DT
cord-006702-ekf6mja9	1203	4	following	follow	VBG
cord-006702-ekf6mja9	1203	5	consequences	consequence	NNS
cord-006702-ekf6mja9	1203	6	in	in	IN
cord-006702-ekf6mja9	1203	7	our	-PRON-	PRP$
cord-006702-ekf6mja9	1203	8	model	model	NN
cord-006702-ekf6mja9	1203	9	:	:	:
cord-006702-ekf6mja9	1203	10	hypertension	hypertension	NN
cord-006702-ekf6mja9	1203	11	,	,	,
cord-006702-ekf6mja9	1203	12	preeclampsia	preeclampsia	NN
cord-006702-ekf6mja9	1203	13	and	and	CC
cord-006702-ekf6mja9	1203	14	end	end	NN
cord-006702-ekf6mja9	1203	15	stage	stage	NN
cord-006702-ekf6mja9	1203	16	renal	renal	JJ
cord-006702-ekf6mja9	1203	17	disease	disease	NN
cord-006702-ekf6mja9	1203	18	.	.	.
cord-006702-ekf6mja9	1204	1	Results	result	NNS
cord-006702-ekf6mja9	1204	2	:	:	:
cord-006702-ekf6mja9	1205	1	Average	average	JJ
cord-006702-ekf6mja9	1205	2	costs	cost	NNS
cord-006702-ekf6mja9	1205	3	of	of	IN
cord-006702-ekf6mja9	1205	4	treatment	treatment	NN
cord-006702-ekf6mja9	1205	5	for	for	IN
cord-006702-ekf6mja9	1205	6	patients	patient	NNS
cord-006702-ekf6mja9	1205	7	who	who	WP
cord-006702-ekf6mja9	1205	8	develop	develop	VBP
cord-006702-ekf6mja9	1205	9	long	long	JJ
cord-006702-ekf6mja9	1205	10	-	-	HYPH
cord-006702-ekf6mja9	1205	11	term	term	NN
cord-006702-ekf6mja9	1205	12	sequelae	sequela	NNS
cord-006702-ekf6mja9	1205	13	is	be	VBZ
cord-006702-ekf6mja9	1205	14	$	$	$
cord-006702-ekf6mja9	1205	15	46,708	46,708	CD
cord-006702-ekf6mja9	1205	16	.	.	.
cord-006702-ekf6mja9	1206	1	Treatment	treatment	NN
cord-006702-ekf6mja9	1206	2	of	of	IN
cord-006702-ekf6mja9	1206	3	all	all	DT
cord-006702-ekf6mja9	1206	4	children	child	NNS
cord-006702-ekf6mja9	1206	5	with	with	IN
cord-006702-ekf6mja9	1206	6	VUR	VUR	NNP
cord-006702-ekf6mja9	1206	7	with	with	IN
cord-006702-ekf6mja9	1206	8	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1206	9	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1206	10	would	would	MD
cord-006702-ekf6mja9	1206	11	cost	cost	VB
cord-006702-ekf6mja9	1206	12	$	$	$
cord-006702-ekf6mja9	1206	13	191,396	191,396	CD
cord-006702-ekf6mja9	1206	14	per	per	IN
cord-006702-ekf6mja9	1206	15	sequelae	sequela	NNS
cord-006702-ekf6mja9	1206	16	avoided	avoid	VBN
cord-006702-ekf6mja9	1206	17	.	.	.
cord-006702-ekf6mja9	1207	1	In	in	IN
cord-006702-ekf6mja9	1207	2	contrast	contrast	NN
cord-006702-ekf6mja9	1207	3	,	,	,
cord-006702-ekf6mja9	1207	4	treatment	treatment	NN
cord-006702-ekf6mja9	1207	5	of	of	IN
cord-006702-ekf6mja9	1207	6	children	child	NNS
cord-006702-ekf6mja9	1207	7	with	with	IN
cord-006702-ekf6mja9	1207	8	both	both	CC
cord-006702-ekf6mja9	1207	9	VUR	VUR	NNP
cord-006702-ekf6mja9	1207	10	and	and	CC
cord-006702-ekf6mja9	1207	11	BBD	BBD	NNP
cord-006702-ekf6mja9	1207	12	with	with	IN
cord-006702-ekf6mja9	1207	13	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1207	14	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1207	15	would	would	MD
cord-006702-ekf6mja9	1207	16	cost	cost	VB
cord-006702-ekf6mja9	1207	17	$	$	$
cord-006702-ekf6mja9	1207	18	42,799	42,799	CD
cord-006702-ekf6mja9	1207	19	per	per	IN
cord-006702-ekf6mja9	1207	20	sequelae	sequela	NNS
cord-006702-ekf6mja9	1207	21	avoided	avoid	VBN
cord-006702-ekf6mja9	1207	22	.	.	.
cord-006702-ekf6mja9	1208	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1208	2	:	:	:
cord-006702-ekf6mja9	1209	1	Antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1209	2	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1209	3	is	be	VBZ
cord-006702-ekf6mja9	1209	4	most	most	RBS
cord-006702-ekf6mja9	1209	5	cost	cost	NN
cord-006702-ekf6mja9	1209	6	-	-	HYPH
cord-006702-ekf6mja9	1209	7	effective	effective	JJ
cord-006702-ekf6mja9	1209	8	in	in	IN
cord-006702-ekf6mja9	1209	9	children	child	NNS
cord-006702-ekf6mja9	1209	10	with	with	IN
cord-006702-ekf6mja9	1209	11	both	both	CC
cord-006702-ekf6mja9	1209	12	VUR	VUR	NNP
cord-006702-ekf6mja9	1209	13	and	and	CC
cord-006702-ekf6mja9	1209	14	BBD	BBD	NNP
cord-006702-ekf6mja9	1209	15	.	.	.
cord-006702-ekf6mja9	1210	1	Screening	screen	VBG
cord-006702-ekf6mja9	1210	2	children	child	NNS
cord-006702-ekf6mja9	1210	3	for	for	IN
cord-006702-ekf6mja9	1210	4	BBD	BBD	NNP
cord-006702-ekf6mja9	1210	5	can	can	MD
cord-006702-ekf6mja9	1210	6	help	help	VB
cord-006702-ekf6mja9	1210	7	select	select	VB
cord-006702-ekf6mja9	1210	8	those	those	DT
cord-006702-ekf6mja9	1210	9	who	who	WP
cord-006702-ekf6mja9	1210	10	would	would	MD
cord-006702-ekf6mja9	1210	11	benefit	benefit	VB
cord-006702-ekf6mja9	1210	12	the	the	DT
cord-006702-ekf6mja9	1210	13	most	most	JJS
cord-006702-ekf6mja9	1210	14	from	from	IN
cord-006702-ekf6mja9	1210	15	long	long	JJ
cord-006702-ekf6mja9	1210	16	-	-	HYPH
cord-006702-ekf6mja9	1210	17	term	term	NN
cord-006702-ekf6mja9	1210	18	antimicrobial	antimicrobial	JJ
cord-006702-ekf6mja9	1210	19	prophylaxis	prophylaxis	NN
cord-006702-ekf6mja9	1210	20	.	.	.
cord-006702-ekf6mja9	1211	1	FP	FP	NNP
cord-006702-ekf6mja9	1211	2	-	-	HYPH
cord-006702-ekf6mja9	1211	3	S32	S32	NNP
cord-006702-ekf6mja9	1211	4	-	-	HYPH
cord-006702-ekf6mja9	1211	5	3	3	CD
cord-006702-ekf6mja9	1211	6	Genetic	genetic	JJ
cord-006702-ekf6mja9	1211	7	discovery	discovery	NN
cord-006702-ekf6mja9	1211	8	in	in	IN
cord-006702-ekf6mja9	1211	9	vesicoureteral	vesicoureteral	JJ
cord-006702-ekf6mja9	1211	10	reflux	reflux	NN
cord-006702-ekf6mja9	1211	11	(	(	-LRB-
cord-006702-ekf6mja9	1211	12	VUR	VUR	NNP
cord-006702-ekf6mja9	1211	13	)	)	-RRB-
cord-006702-ekf6mja9	1212	1	using	use	VBG
cord-006702-ekf6mja9	1212	2	exome	exome	NNP
cord-006702-ekf6mja9	1212	3	sequencing	sequencing	NN
cord-006702-ekf6mja9	1212	4	:	:	:
cord-006702-ekf6mja9	1212	5	a	a	DT
cord-006702-ekf6mja9	1212	6	pilot	pilot	NN
cord-006702-ekf6mja9	1212	7	study	study	NN
cord-006702-ekf6mja9	1212	8	R.	R.	NNP
cord-006702-ekf6mja9	1212	9	Thergaonkar	Thergaonkar	NNP
cord-006702-ekf6mja9	1212	10	(	(	-LRB-
cord-006702-ekf6mja9	1212	11	1	1	CD
cord-006702-ekf6mja9	1212	12	)	)	-RRB-
cord-006702-ekf6mja9	1212	13	,	,	,
cord-006702-ekf6mja9	1212	14	V.	V.	NNP
cord-006702-ekf6mja9	1212	15	Manchanda	Manchanda	NNP
cord-006702-ekf6mja9	1212	16	(	(	-LRB-
cord-006702-ekf6mja9	1212	17	2	2	CD
cord-006702-ekf6mja9	1212	18	)	)	-RRB-
cord-006702-ekf6mja9	1212	19	,	,	,
cord-006702-ekf6mja9	1212	20	A.	A.	NNP
cord-006702-ekf6mja9	1212	21	Yadav	Yadav	NNP
cord-006702-ekf6mja9	1212	22	(	(	-LRB-
cord-006702-ekf6mja9	1212	23	2	2	CD
cord-006702-ekf6mja9	1212	24	)	)	-RRB-
cord-006702-ekf6mja9	1212	25	,	,	,
cord-006702-ekf6mja9	1212	26	B.	B.	NNP
cord-006702-ekf6mja9	1212	27	Varma	Varma	NNP
cord-006702-ekf6mja9	1212	28	(	(	-LRB-
cord-006702-ekf6mja9	1212	29	2	2	CD
cord-006702-ekf6mja9	1212	30	)	)	-RRB-
cord-006702-ekf6mja9	1212	31	,	,	,
cord-006702-ekf6mja9	1212	32	D.	D.	NNP
cord-006702-ekf6mja9	1212	33	Dash	Dash	NNP
cord-006702-ekf6mja9	1212	34	(	(	-LRB-
cord-006702-ekf6mja9	1212	35	2	2	CD
cord-006702-ekf6mja9	1212	36	)	)	-RRB-
cord-006702-ekf6mja9	1212	37	,	,	,
cord-006702-ekf6mja9	1212	38	M.	M.	NNP
cord-006702-ekf6mja9	1212	39	Mukerji	Mukerji	NNP
cord-006702-ekf6mja9	1212	40	(	(	-LRB-
cord-006702-ekf6mja9	1212	41	2	2	CD
cord-006702-ekf6mja9	1212	42	)	)	-RRB-
cord-006702-ekf6mja9	1212	43	,	,	,
cord-006702-ekf6mja9	1212	44	A.	A.	NNP
cord-006702-ekf6mja9	1212	45	Bagga	Bagga	NNP
cord-006702-ekf6mja9	1212	46	(	(	-LRB-
cord-006702-ekf6mja9	1212	47	1	1	CD
cord-006702-ekf6mja9	1212	48	)	)	-RRB-
cord-006702-ekf6mja9	1212	49	,	,	,
cord-006702-ekf6mja9	1212	50	P.	P.	NNP
cord-006702-ekf6mja9	1212	51	Hari	Hari	NNP
cord-006702-ekf6mja9	1212	52	(	(	-LRB-
cord-006702-ekf6mja9	1212	53	1	1	CD
cord-006702-ekf6mja9	1213	1	In	in	IN
cord-006702-ekf6mja9	1213	2	the	the	DT
cord-006702-ekf6mja9	1213	3	family	family	NN
cord-006702-ekf6mja9	1213	4	,	,	,
cord-006702-ekf6mja9	1213	5	autosomal	autosomal	JJ
cord-006702-ekf6mja9	1213	6	dominant	dominant	JJ
cord-006702-ekf6mja9	1213	7	(	(	-LRB-
cord-006702-ekf6mja9	1213	8	AD	ad	NN
cord-006702-ekf6mja9	1213	9	)	)	-RRB-
cord-006702-ekf6mja9	1213	10	,	,	,
cord-006702-ekf6mja9	1213	11	recessive	recessive	JJ
cord-006702-ekf6mja9	1213	12	(	(	-LRB-
cord-006702-ekf6mja9	1213	13	AR	AR	NNP
cord-006702-ekf6mja9	1213	14	)	)	-RRB-
cord-006702-ekf6mja9	1213	15	and	and	CC
cord-006702-ekf6mja9	1214	1	X	X	NNS
cord-006702-ekf6mja9	1214	2	-	-	VBN
cord-006702-ekf6mja9	1214	3	linked	link	VBN
cord-006702-ekf6mja9	1214	4	(	(	-LRB-
cord-006702-ekf6mja9	1214	5	XL	XL	NNP
cord-006702-ekf6mja9	1214	6	)	)	-RRB-
cord-006702-ekf6mja9	1214	7	models	model	NNS
cord-006702-ekf6mja9	1214	8	were	be	VBD
cord-006702-ekf6mja9	1214	9	used	use	VBN
cord-006702-ekf6mja9	1214	10	.	.	.
cord-006702-ekf6mja9	1215	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1215	2	:	:	:
cord-006702-ekf6mja9	1216	1	Immunization	immunization	NN
cord-006702-ekf6mja9	1216	2	with	with	IN
cord-006702-ekf6mja9	1216	3	various	various	JJ
cord-006702-ekf6mja9	1216	4	vaccines	vaccine	NNS
cord-006702-ekf6mja9	1216	5	is	be	VBZ
cord-006702-ekf6mja9	1216	6	recommended	recommend	VBN
cord-006702-ekf6mja9	1216	7	for	for	IN
cord-006702-ekf6mja9	1216	8	children	child	NNS
cord-006702-ekf6mja9	1216	9	with	with	IN
cord-006702-ekf6mja9	1216	10	idiopathic	idiopathic	JJ
cord-006702-ekf6mja9	1216	11	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	1216	12	syndrome	syndrome	NN
cord-006702-ekf6mja9	1216	13	(	(	-LRB-
cord-006702-ekf6mja9	1216	14	NS	NS	NNP
cord-006702-ekf6mja9	1216	15	)	)	-RRB-
cord-006702-ekf6mja9	1216	16	because	because	IN
cord-006702-ekf6mja9	1216	17	of	of	IN
cord-006702-ekf6mja9	1216	18	their	-PRON-	PRP$
cord-006702-ekf6mja9	1216	19	high	high	JJ
cord-006702-ekf6mja9	1216	20	risk	risk	NN
cord-006702-ekf6mja9	1216	21	for	for	IN
cord-006702-ekf6mja9	1216	22	severe	severe	JJ
cord-006702-ekf6mja9	1216	23	infections	infection	NNS
cord-006702-ekf6mja9	1216	24	.	.	.
cord-006702-ekf6mja9	1217	1	While	while	IN
cord-006702-ekf6mja9	1217	2	vaccinations	vaccination	NNS
cord-006702-ekf6mja9	1217	3	could	could	MD
cord-006702-ekf6mja9	1217	4	precipitate	precipitate	VB
cord-006702-ekf6mja9	1217	5	NS	NS	NNP
cord-006702-ekf6mja9	1217	6	relapses	relapse	NNS
cord-006702-ekf6mja9	1217	7	,	,	,
cord-006702-ekf6mja9	1217	8	there	there	EX
cord-006702-ekf6mja9	1217	9	are	be	VBP
cord-006702-ekf6mja9	1217	10	no	no	DT
cord-006702-ekf6mja9	1217	11	available	available	JJ
cord-006702-ekf6mja9	1217	12	data	datum	NNS
cord-006702-ekf6mja9	1217	13	regarding	regard	VBG
cord-006702-ekf6mja9	1217	14	influenza	influenza	NN
cord-006702-ekf6mja9	1217	15	(	(	-LRB-
cord-006702-ekf6mja9	1217	16	flu	flu	NN
cord-006702-ekf6mja9	1217	17	)	)	-RRB-
cord-006702-ekf6mja9	1217	18	virus	virus	NN
cord-006702-ekf6mja9	1217	19	vaccines	vaccine	NNS
cord-006702-ekf6mja9	1217	20	.	.	.
cord-006702-ekf6mja9	1218	1	Methods	method	NNS
cord-006702-ekf6mja9	1218	2	:	:	:
cord-006702-ekf6mja9	1218	3	We	-PRON-	PRP
cord-006702-ekf6mja9	1218	4	retrospectively	retrospectively	RB
cord-006702-ekf6mja9	1218	5	reviewed	review	VBD
cord-006702-ekf6mja9	1218	6	the	the	DT
cord-006702-ekf6mja9	1218	7	medical	medical	JJ
cord-006702-ekf6mja9	1218	8	records	record	NNS
cord-006702-ekf6mja9	1218	9	of	of	IN
cord-006702-ekf6mja9	1218	10	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1218	11	patients	patient	NNS
cord-006702-ekf6mja9	1218	12	with	with	IN
cord-006702-ekf6mja9	1218	13	NS	NS	NNP
cord-006702-ekf6mja9	1218	14	who	who	WP
cord-006702-ekf6mja9	1218	15	had	have	VBD
cord-006702-ekf6mja9	1218	16	received	receive	VBN
cord-006702-ekf6mja9	1218	17	flu	flu	NN
cord-006702-ekf6mja9	1218	18	vaccines	vaccine	NNS
cord-006702-ekf6mja9	1218	19	between	between	IN
cord-006702-ekf6mja9	1218	20	2002	2002	CD
cord-006702-ekf6mja9	1218	21	and	and	CC
cord-006702-ekf6mja9	1218	22	2015	2015	CD
cord-006702-ekf6mja9	1218	23	.	.	.
cord-006702-ekf6mja9	1219	1	The	the	DT
cord-006702-ekf6mja9	1219	2	period	period	NN
cord-006702-ekf6mja9	1219	3	from	from	IN
cord-006702-ekf6mja9	1219	4	pre	pre	JJ
cord-006702-ekf6mja9	1219	5	-	-	JJ
cord-006702-ekf6mja9	1219	6	vaccination	vaccination	JJ
cord-006702-ekf6mja9	1219	7	days	day	NNS
cord-006702-ekf6mja9	1219	8	to	to	TO
cord-006702-ekf6mja9	1219	9	post	post	VB
cord-006702-ekf6mja9	1219	10	-	-	JJ
cord-006702-ekf6mja9	1219	11	vaccination	vaccination	JJ
cord-006702-ekf6mja9	1219	12	days	day	NNS
cord-006702-ekf6mja9	1219	13	was	be	VBD
cord-006702-ekf6mja9	1219	14	defined	define	VBN
cord-006702-ekf6mja9	1219	15	as	as	IN
cord-006702-ekf6mja9	1219	16	-X	-X	NNS
cord-006702-ekf6mja9	1219	17	to	to	IN
cord-006702-ekf6mja9	1219	18	+	+	CD
cord-006702-ekf6mja9	1220	1	Y.	Y.	NNP
cord-006702-ekf6mja9	1220	2	Flu	Flu	NNP
cord-006702-ekf6mja9	1220	3	vaccines	vaccine	NNS
cord-006702-ekf6mja9	1220	4	were	be	VBD
cord-006702-ekf6mja9	1220	5	given	give	VBN
cord-006702-ekf6mja9	1220	6	during	during	IN
cord-006702-ekf6mja9	1220	7	except	except	IN
cord-006702-ekf6mja9	1220	8	for	for	IN
cord-006702-ekf6mja9	1220	9	the	the	DT
cord-006702-ekf6mja9	1220	10	period	period	NN
cord-006702-ekf6mja9	1220	11	administered	administer	VBD
cord-006702-ekf6mja9	1220	12	2	2	CD
cord-006702-ekf6mja9	1220	13	mg	mg	NNP
cord-006702-ekf6mja9	1220	14	/	/	SYM
cord-006702-ekf6mja9	1220	15	kg	kg	NNP
cord-006702-ekf6mja9	1220	16	/	/	SYM
cord-006702-ekf6mja9	1220	17	day	day	NN
cord-006702-ekf6mja9	1220	18	of	of	IN
cord-006702-ekf6mja9	1220	19	prednisolone	prednisolone	NN
cord-006702-ekf6mja9	1220	20	or	or	CC
cord-006702-ekf6mja9	1220	21	on	on	IN
cord-006702-ekf6mja9	1220	22	relapses	relapse	NNS
cord-006702-ekf6mja9	1220	23	.	.	.
cord-006702-ekf6mja9	1221	1	Comparison	comparison	NN
cord-006702-ekf6mja9	1221	2	of	of	IN
cord-006702-ekf6mja9	1221	3	NS	NS	NNP
cord-006702-ekf6mja9	1221	4	relapse	relapse	NN
cord-006702-ekf6mja9	1221	5	rates	rate	NNS
cord-006702-ekf6mja9	1221	6	in	in	IN
cord-006702-ekf6mja9	1221	7	pre	pre	JJ
cord-006702-ekf6mja9	1221	8	-	-	JJ
cord-006702-ekf6mja9	1221	9	or	or	CC
cord-006702-ekf6mja9	1221	10	post	post	JJ
cord-006702-ekf6mja9	1221	11	-	-	JJ
cord-006702-ekf6mja9	1221	12	flu	flu	JJ
cord-006702-ekf6mja9	1221	13	vaccination	vaccination	NN
cord-006702-ekf6mja9	1221	14	periods	period	NNS
cord-006702-ekf6mja9	1221	15	was	be	VBD
cord-006702-ekf6mja9	1221	16	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1221	17	using	use	VBG
cord-006702-ekf6mja9	1221	18	poisson	poisson	NN
cord-006702-ekf6mja9	1221	19	method	method	NN
cord-006702-ekf6mja9	1221	20	.	.	.
cord-006702-ekf6mja9	1222	1	Risk	risk	NN
cord-006702-ekf6mja9	1222	2	factors	factor	NNS
cord-006702-ekf6mja9	1222	3	for	for	IN
cord-006702-ekf6mja9	1222	4	NS	NS	NNP
cord-006702-ekf6mja9	1222	5	relapses	relapse	NNS
cord-006702-ekf6mja9	1222	6	were	be	VBD
cord-006702-ekf6mja9	1222	7	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1222	8	using	use	VBG
cord-006702-ekf6mja9	1222	9	generalized	generalized	JJ
cord-006702-ekf6mja9	1222	10	linear	linear	JJ
cord-006702-ekf6mja9	1222	11	mixed	mixed	JJ
cord-006702-ekf6mja9	1222	12	model	model	NN
cord-006702-ekf6mja9	1222	13	about	about	IN
cord-006702-ekf6mja9	1222	14	parameters	parameter	NNS
cord-006702-ekf6mja9	1222	15	such	such	JJ
cord-006702-ekf6mja9	1222	16	as	as	IN
cord-006702-ekf6mja9	1222	17	pre	pre	JJ
cord-006702-ekf6mja9	1222	18	-	-	JJ
cord-006702-ekf6mja9	1222	19	or	or	CC
cord-006702-ekf6mja9	1222	20	post	post	JJ
cord-006702-ekf6mja9	1222	21	-	-	JJ
cord-006702-ekf6mja9	1222	22	flu	flu	JJ
cord-006702-ekf6mja9	1222	23	vaccinations	vaccination	NNS
cord-006702-ekf6mja9	1222	24	,	,	,
cord-006702-ekf6mja9	1222	25	sex	sex	NN
cord-006702-ekf6mja9	1222	26	,	,	,
cord-006702-ekf6mja9	1222	27	age	age	NN
cord-006702-ekf6mja9	1222	28	at	at	IN
cord-006702-ekf6mja9	1222	29	onset	onset	NN
cord-006702-ekf6mja9	1222	30	of	of	IN
cord-006702-ekf6mja9	1222	31	NS	NS	NNP
cord-006702-ekf6mja9	1222	32	,	,	,
cord-006702-ekf6mja9	1222	33	past	past	IN
cord-006702-ekf6mja9	1222	34	history	history	NN
cord-006702-ekf6mja9	1222	35	of	of	IN
cord-006702-ekf6mja9	1222	36	steroid	steroid	NN
cord-006702-ekf6mja9	1222	37	resistant	resistant	JJ
cord-006702-ekf6mja9	1222	38	,	,	,
cord-006702-ekf6mja9	1222	39	renal	renal	JJ
cord-006702-ekf6mja9	1222	40	histology	histology	NN
cord-006702-ekf6mja9	1222	41	,	,	,
cord-006702-ekf6mja9	1222	42	being	be	VBG
cord-006702-ekf6mja9	1222	43	on	on	IN
cord-006702-ekf6mja9	1222	44	various	various	JJ
cord-006702-ekf6mja9	1222	45	immunosuppressants	immunosuppressant	NNS
cord-006702-ekf6mja9	1222	46	or	or	CC
cord-006702-ekf6mja9	1222	47	not	not	RB
cord-006702-ekf6mja9	1222	48	.	.	.
cord-006702-ekf6mja9	1223	1	Results	result	NNS
cord-006702-ekf6mja9	1223	2	:	:	:
cord-006702-ekf6mja9	1224	1	A	a	DT
cord-006702-ekf6mja9	1224	2	total	total	NN
cord-006702-ekf6mja9	1224	3	of	of	IN
cord-006702-ekf6mja9	1224	4	104	104	CD
cord-006702-ekf6mja9	1224	5	pediatric	pediatric	JJ
cord-006702-ekf6mja9	1224	6	patients	patient	NNS
cord-006702-ekf6mja9	1224	7	(	(	-LRB-
cord-006702-ekf6mja9	1224	8	73	73	CD
cord-006702-ekf6mja9	1224	9	boys	boy	NNS
cord-006702-ekf6mja9	1224	10	and	and	CC
cord-006702-ekf6mja9	1224	11	31	31	CD
cord-006702-ekf6mja9	1224	12	girls	girl	NNS
cord-006702-ekf6mja9	1224	13	)	)	-RRB-
cord-006702-ekf6mja9	1224	14	received	receive	VBD
cord-006702-ekf6mja9	1224	15	208	208	CD
cord-006702-ekf6mja9	1224	16	flu	flu	NN
cord-006702-ekf6mja9	1224	17	vaccines	vaccine	NNS
cord-006702-ekf6mja9	1224	18	.	.	.
cord-006702-ekf6mja9	1225	1	Mean	mean	JJ
cord-006702-ekf6mja9	1225	2	age	age	NN
cord-006702-ekf6mja9	1225	3	at	at	IN
cord-006702-ekf6mja9	1225	4	onset	onset	NN
cord-006702-ekf6mja9	1225	5	of	of	IN
cord-006702-ekf6mja9	1225	6	NS	NS	NNP
cord-006702-ekf6mja9	1225	7	,	,	,
cord-006702-ekf6mja9	1225	8	mean	mean	VB
cord-006702-ekf6mja9	1225	9	age	age	NN
cord-006702-ekf6mja9	1225	10	at	at	IN
cord-006702-ekf6mja9	1225	11	first	first	JJ
cord-006702-ekf6mja9	1225	12	flu	flu	NN
cord-006702-ekf6mja9	1225	13	vaccinations	vaccination	NNS
cord-006702-ekf6mja9	1225	14	,	,	,
cord-006702-ekf6mja9	1225	15	and	and	CC
cord-006702-ekf6mja9	1225	16	mean	mean	VB
cord-006702-ekf6mja9	1225	17	observation	observation	NN
cord-006702-ekf6mja9	1225	18	period	period	NN
cord-006702-ekf6mja9	1225	19	were	be	VBD
cord-006702-ekf6mja9	1225	20	4.85	4.85	CD
cord-006702-ekf6mja9	1225	21	±	±	CD
cord-006702-ekf6mja9	1225	22	3.87	3.87	CD
cord-006702-ekf6mja9	1225	23	years	year	NNS
cord-006702-ekf6mja9	1225	24	old	old	JJ
cord-006702-ekf6mja9	1225	25	,	,	,
cord-006702-ekf6mja9	1225	26	7.76	7.76	CD
cord-006702-ekf6mja9	1225	27	±	±	CD
cord-006702-ekf6mja9	1225	28	5.10	5.10	CD
cord-006702-ekf6mja9	1225	29	years	year	NNS
cord-006702-ekf6mja9	1225	30	old	old	JJ
cord-006702-ekf6mja9	1225	31	,	,	,
cord-006702-ekf6mja9	1225	32	and	and	CC
cord-006702-ekf6mja9	1225	33	2.64	2.64	CD
cord-006702-ekf6mja9	1225	34	±	±	CD
cord-006702-ekf6mja9	1225	35	2.20	2.20	CD
cord-006702-ekf6mja9	1225	36	years	year	NNS
cord-006702-ekf6mja9	1225	37	,	,	,
cord-006702-ekf6mja9	1225	38	respectively	respectively	RB
cord-006702-ekf6mja9	1225	39	.	.	.
cord-006702-ekf6mja9	1226	1	During	during	IN
cord-006702-ekf6mja9	1226	2	-180	-180	NN
cord-006702-ekf6mja9	1226	3	to	to	IN
cord-006702-ekf6mja9	1226	4	+180	+180	NNP
cord-006702-ekf6mja9	1226	5	,	,	,
cord-006702-ekf6mja9	1226	6	the	the	DT
cord-006702-ekf6mja9	1226	7	total	total	JJ
cord-006702-ekf6mja9	1226	8	number	number	NN
cord-006702-ekf6mja9	1226	9	of	of	IN
cord-006702-ekf6mja9	1226	10	NS	NS	NNP
cord-006702-ekf6mja9	1226	11	relapses	relapse	NNS
cord-006702-ekf6mja9	1226	12	and	and	CC
cord-006702-ekf6mja9	1226	13	relapse	relapse	NN
cord-006702-ekf6mja9	1226	14	rate	rate	NN
cord-006702-ekf6mja9	1226	15	were	be	VBD
cord-006702-ekf6mja9	1226	16	274	274	CD
cord-006702-ekf6mja9	1226	17	episodes	episode	NNS
cord-006702-ekf6mja9	1226	18	and	and	CC
cord-006702-ekf6mja9	1226	19	1.33	1.33	CD
cord-006702-ekf6mja9	1226	20	times	time	NNS
cord-006702-ekf6mja9	1226	21	/	/	SYM
cord-006702-ekf6mja9	1226	22	personï½¥year	personï½¥year	NNP
cord-006702-ekf6mja9	1226	23	,	,	,
cord-006702-ekf6mja9	1226	24	respectively	respectively	RB
cord-006702-ekf6mja9	1226	25	.	.	.
cord-006702-ekf6mja9	1227	1	Compared	compare	VBN
cord-006702-ekf6mja9	1227	2	with	with	IN
cord-006702-ekf6mja9	1227	3	relapse	relapse	NN
cord-006702-ekf6mja9	1227	4	rate	rate	NN
cord-006702-ekf6mja9	1227	5	in	in	IN
cord-006702-ekf6mja9	1227	6	-180	-180	NN
cord-006702-ekf6mja9	1227	7	to	to	IN
cord-006702-ekf6mja9	1227	8	0	0	CD
cord-006702-ekf6mja9	1227	9	(	(	-LRB-
cord-006702-ekf6mja9	1227	10	1.20	1.20	CD
cord-006702-ekf6mja9	1227	11	times/	times/	NN
cord-006702-ekf6mja9	1227	12	personï½¥year	personï½¥year	NNP
cord-006702-ekf6mja9	1227	13	)	)	-RRB-
cord-006702-ekf6mja9	1227	14	,	,	,
cord-006702-ekf6mja9	1227	15	those	those	DT
cord-006702-ekf6mja9	1227	16	in	in	IN
cord-006702-ekf6mja9	1227	17	0	0	CD
cord-006702-ekf6mja9	1227	18	to	to	IN
cord-006702-ekf6mja9	1227	19	+30	+30	CD
cord-006702-ekf6mja9	1227	20	,	,	,
cord-006702-ekf6mja9	1227	21	0	0	CD
cord-006702-ekf6mja9	1227	22	to	to	IN
cord-006702-ekf6mja9	1227	23	+	+	SYM
cord-006702-ekf6mja9	1227	24	60	60	CD
cord-006702-ekf6mja9	1227	25	and	and	CC
cord-006702-ekf6mja9	1227	26	0	0	CD
cord-006702-ekf6mja9	1227	27	to	to	TO
cord-006702-ekf6mja9	1227	28	+	+	SYM
cord-006702-ekf6mja9	1227	29	180	180	CD
cord-006702-ekf6mja9	1227	30	were	be	VBD
cord-006702-ekf6mja9	1227	31	1.38	1.38	CD
cord-006702-ekf6mja9	1227	32	(	(	-LRB-
cord-006702-ekf6mja9	1227	33	risk	risk	NN
cord-006702-ekf6mja9	1227	34	ratio	ratio	NN
cord-006702-ekf6mja9	1227	35	(	(	-LRB-
cord-006702-ekf6mja9	1227	36	RR	rr	NN
cord-006702-ekf6mja9	1227	37	)	)	-RRB-
cord-006702-ekf6mja9	1227	38	:	:	:
cord-006702-ekf6mja9	1227	39	1.14	1.14	CD
cord-006702-ekf6mja9	1227	40	,	,	,
cord-006702-ekf6mja9	1227	41	95	95	CD
cord-006702-ekf6mja9	1227	42	%	%	NN
cord-006702-ekf6mja9	1227	43	confidence	confidence	NN
cord-006702-ekf6mja9	1227	44	interval	interval	NN
cord-006702-ekf6mja9	1227	45	(	(	-LRB-
cord-006702-ekf6mja9	1227	46	CI	CI	NNP
cord-006702-ekf6mja9	1227	47	)	)	-RRB-
cord-006702-ekf6mja9	1227	48	:	:	:
cord-006702-ekf6mja9	1228	1	0.75	0.75	CD
cord-006702-ekf6mja9	1228	2	-	-	SYM
cord-006702-ekf6mja9	1228	3	1	1	CD
cord-006702-ekf6mja9	1228	4	.	.	.
cord-006702-ekf6mja9	1229	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1229	2	:	:	:
cord-006702-ekf6mja9	1229	3	To	to	TO
cord-006702-ekf6mja9	1229	4	evaluate	evaluate	VB
cord-006702-ekf6mja9	1229	5	the	the	DT
cord-006702-ekf6mja9	1229	6	imaging	imaging	NN
cord-006702-ekf6mja9	1229	7	results	result	NNS
cord-006702-ekf6mja9	1229	8	of	of	IN
cord-006702-ekf6mja9	1229	9	childhood	childhood	NN
cord-006702-ekf6mja9	1229	10	UTI	UTI	NNP
cord-006702-ekf6mja9	1229	11	in	in	IN
cord-006702-ekf6mja9	1229	12	a	a	DT
cord-006702-ekf6mja9	1229	13	developing	develop	VBG
cord-006702-ekf6mja9	1229	14	country	country	NN
cord-006702-ekf6mja9	1229	15	setting	setting	NN
cord-006702-ekf6mja9	1229	16	,	,	,
cord-006702-ekf6mja9	1229	17	and	and	CC
cord-006702-ekf6mja9	1229	18	examine	examine	VB
cord-006702-ekf6mja9	1229	19	if	if	IN
cord-006702-ekf6mja9	1229	20	it	-PRON-	PRP
cord-006702-ekf6mja9	1229	21	would	would	MD
cord-006702-ekf6mja9	1229	22	be	be	VB
cord-006702-ekf6mja9	1229	23	appropriate	appropriate	JJ
cord-006702-ekf6mja9	1229	24	to	to	TO
cord-006702-ekf6mja9	1229	25	apply	apply	VB
cord-006702-ekf6mja9	1229	26	the	the	DT
cord-006702-ekf6mja9	1229	27	recent	recent	JJ
cord-006702-ekf6mja9	1229	28	guideline	guideline	NN
cord-006702-ekf6mja9	1229	29	changes	change	NNS
cord-006702-ekf6mja9	1229	30	regarding	regard	VBG
cord-006702-ekf6mja9	1229	31	imaging	imaging	NN
cord-006702-ekf6mja9	1229	32	studies	study	NNS
cord-006702-ekf6mja9	1229	33	as	as	IN
cord-006702-ekf6mja9	1229	34	routine	routine	JJ
cord-006702-ekf6mja9	1229	35	practice	practice	NN
cord-006702-ekf6mja9	1229	36	in	in	IN
cord-006702-ekf6mja9	1229	37	Thailand	Thailand	NNP
cord-006702-ekf6mja9	1229	38	.	.	.
cord-006702-ekf6mja9	1230	1	Methods	method	NNS
cord-006702-ekf6mja9	1230	2	:	:	:
cord-006702-ekf6mja9	1230	3	Medical	medical	JJ
cord-006702-ekf6mja9	1230	4	records	record	NNS
cord-006702-ekf6mja9	1230	5	of	of	IN
cord-006702-ekf6mja9	1230	6	children	child	NNS
cord-006702-ekf6mja9	1230	7	aged	age	VBN
cord-006702-ekf6mja9	1230	8	0	0	CD
cord-006702-ekf6mja9	1230	9	-	-	SYM
cord-006702-ekf6mja9	1230	10	15	15	CD
cord-006702-ekf6mja9	1230	11	years	year	NNS
cord-006702-ekf6mja9	1230	12	who	who	WP
cord-006702-ekf6mja9	1230	13	had	have	VBD
cord-006702-ekf6mja9	1230	14	UTI	UTI	NNP
cord-006702-ekf6mja9	1230	15	and	and	CC
cord-006702-ekf6mja9	1230	16	were	be	VBD
cord-006702-ekf6mja9	1230	17	admitted	admit	VBN
cord-006702-ekf6mja9	1230	18	at	at	IN
cord-006702-ekf6mja9	1230	19	the	the	DT
cord-006702-ekf6mja9	1230	20	Department	Department	NNP
cord-006702-ekf6mja9	1230	21	of	of	IN
cord-006702-ekf6mja9	1230	22	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	1230	23	,	,	,
cord-006702-ekf6mja9	1230	24	Prince	Prince	NNP
cord-006702-ekf6mja9	1230	25	of	of	IN
cord-006702-ekf6mja9	1230	26	Songkla	Songkla	NNP
cord-006702-ekf6mja9	1230	27	University	University	NNP
cord-006702-ekf6mja9	1230	28	from	from	IN
cord-006702-ekf6mja9	1230	29	January	January	NNP
cord-006702-ekf6mja9	1230	30	2004	2004	CD
cord-006702-ekf6mja9	1231	1	-December	-December	NNP
cord-006702-ekf6mja9	1231	2	2013	2013	CD
cord-006702-ekf6mja9	1231	3	were	be	VBD
cord-006702-ekf6mja9	1231	4	reviewed	review	VBN
cord-006702-ekf6mja9	1231	5	.	.	.
cord-006702-ekf6mja9	1232	1	Renal	renal	JJ
cord-006702-ekf6mja9	1232	2	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	1232	3	(	(	-LRB-
cord-006702-ekf6mja9	1232	4	RUS	RUS	NNP
cord-006702-ekf6mja9	1232	5	)	)	-RRB-
cord-006702-ekf6mja9	1232	6	,	,	,
cord-006702-ekf6mja9	1232	7	cystogram	cystogram	NNP
cord-006702-ekf6mja9	1232	8	and	and	CC
cord-006702-ekf6mja9	1232	9	99	99	CD
cord-006702-ekf6mja9	1232	10	m	m	NN
cord-006702-ekf6mja9	1232	11	Tc	Tc	NNP
cord-006702-ekf6mja9	1232	12	dimercaptosuccinic	dimercaptosuccinic	JJ
cord-006702-ekf6mja9	1232	13	acid	acid	NN
cord-006702-ekf6mja9	1232	14	(	(	-LRB-
cord-006702-ekf6mja9	1232	15	DMSA	DMSA	NNP
cord-006702-ekf6mja9	1232	16	)	)	-RRB-
cord-006702-ekf6mja9	1232	17	renal	renal	JJ
cord-006702-ekf6mja9	1232	18	scanresults	scanresult	NNS
cord-006702-ekf6mja9	1232	19	to	to	TO
cord-006702-ekf6mja9	1232	20	determine	determine	VB
cord-006702-ekf6mja9	1232	21	congenital	congenital	JJ
cord-006702-ekf6mja9	1232	22	anomalies	anomaly	NNS
cord-006702-ekf6mja9	1232	23	of	of	IN
cord-006702-ekf6mja9	1232	24	the	the	DT
cord-006702-ekf6mja9	1232	25	kidney	kidney	NN
cord-006702-ekf6mja9	1232	26	and	and	CC
cord-006702-ekf6mja9	1232	27	urinary	urinary	JJ
cord-006702-ekf6mja9	1232	28	tract	tract	NN
cord-006702-ekf6mja9	1232	29	(	(	-LRB-
cord-006702-ekf6mja9	1232	30	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1232	31	)	)	-RRB-
cord-006702-ekf6mja9	1232	32	and	and	CC
cord-006702-ekf6mja9	1232	33	renal	renal	JJ
cord-006702-ekf6mja9	1232	34	damage	damage	NN
cord-006702-ekf6mja9	1232	35	were	be	VBD
cord-006702-ekf6mja9	1232	36	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1232	37	.	.	.
cord-006702-ekf6mja9	1233	1	Mild	mild	JJ
cord-006702-ekf6mja9	1233	2	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1233	3	was	be	VBD
cord-006702-ekf6mja9	1233	4	defined	define	VBN
cord-006702-ekf6mja9	1233	5	as	as	IN
cord-006702-ekf6mja9	1233	6	primary	primary	JJ
cord-006702-ekf6mja9	1233	7	VUR	VUR	NNP
cord-006702-ekf6mja9	1233	8	grades	grade	NNS
cord-006702-ekf6mja9	1233	9	I	I	NNP
cord-006702-ekf6mja9	1233	10	-	-	HYPH
cord-006702-ekf6mja9	1233	11	III	III	NNP
cord-006702-ekf6mja9	1233	12	or	or	CC
cord-006702-ekf6mja9	1233	13	isolated	isolate	VBN
cord-006702-ekf6mja9	1233	14	hydronephrosis	hydronephrosis	NN
cord-006702-ekf6mja9	1233	15	and	and	CC
cord-006702-ekf6mja9	1233	16	all	all	DT
cord-006702-ekf6mja9	1233	17	other	other	JJ
cord-006702-ekf6mja9	1233	18	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	1233	19	were	be	VBD
cord-006702-ekf6mja9	1233	20	defined	define	VBN
cord-006702-ekf6mja9	1233	21	as	as	IN
cord-006702-ekf6mja9	1233	22	severe	severe	JJ
cord-006702-ekf6mja9	1233	23	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1233	24	.	.	.
cord-006702-ekf6mja9	1234	1	Results	result	NNS
cord-006702-ekf6mja9	1234	2	:	:	:
cord-006702-ekf6mja9	1235	1	142	142	CD
cord-006702-ekf6mja9	1235	2	boys	boy	NNS
cord-006702-ekf6mja9	1235	3	and	and	CC
cord-006702-ekf6mja9	1235	4	129	129	CD
cord-006702-ekf6mja9	1235	5	girls	girl	NNS
cord-006702-ekf6mja9	1235	6	had	have	VBD
cord-006702-ekf6mja9	1235	7	at	at	RB
cord-006702-ekf6mja9	1235	8	least	least	RBS
cord-006702-ekf6mja9	1235	9	one	one	CD
cord-006702-ekf6mja9	1235	10	imaging	imaging	NN
cord-006702-ekf6mja9	1235	11	study	study	NN
cord-006702-ekf6mja9	1235	12	after	after	IN
cord-006702-ekf6mja9	1235	13	UTI	UTI	NNP
cord-006702-ekf6mja9	1235	14	.	.	.
cord-006702-ekf6mja9	1236	1	Their	-PRON-	PRP$
cord-006702-ekf6mja9	1236	2	median	median	NN
cord-006702-ekf6mja9	1236	3	(	(	-LRB-
cord-006702-ekf6mja9	1236	4	IQR	IQR	NNP
cord-006702-ekf6mja9	1236	5	)	)	-RRB-
cord-006702-ekf6mja9	1236	6	age	age	NN
cord-006702-ekf6mja9	1236	7	was	be	VBD
cord-006702-ekf6mja9	1236	8	1.0	1.0	CD
cord-006702-ekf6mja9	1236	9	(	(	-LRB-
cord-006702-ekf6mja9	1236	10	0.5	0.5	CD
cord-006702-ekf6mja9	1236	11	-2.7	-2.7	CD
cord-006702-ekf6mja9	1236	12	)	)	-RRB-
cord-006702-ekf6mja9	1236	13	year	year	NN
cord-006702-ekf6mja9	1236	14	;	;	:
cord-006702-ekf6mja9	1236	15	0.7	0.7	CD
cord-006702-ekf6mja9	1236	16	and	and	CC
cord-006702-ekf6mja9	1236	17	1.4	1.4	CD
cord-006702-ekf6mja9	1236	18	years	year	NNS
cord-006702-ekf6mja9	1236	19	for	for	IN
cord-006702-ekf6mja9	1236	20	boys	boy	NNS
cord-006702-ekf6mja9	1236	21	and	and	CC
cord-006702-ekf6mja9	1236	22	girls	girl	NNS
cord-006702-ekf6mja9	1236	23	,	,	.
cord-006702-ekf6mja9	1237	1	respectively	respectively	RB
cord-006702-ekf6mja9	1237	2	(	(	-LRB-
cord-006702-ekf6mja9	1237	3	p=0.006).262	p=0.006).262	NFP
cord-006702-ekf6mja9	1237	4	children	child	NNS
cord-006702-ekf6mja9	1237	5	had	have	VBD
cord-006702-ekf6mja9	1237	6	an	an	DT
cord-006702-ekf6mja9	1237	7	RUS	RUS	NNP
cord-006702-ekf6mja9	1237	8	performed	perform	VBN
cord-006702-ekf6mja9	1237	9	,	,	,
cord-006702-ekf6mja9	1237	10	of	of	IN
cord-006702-ekf6mja9	1237	11	which	which	WDT
cord-006702-ekf6mja9	1237	12	99	99	CD
cord-006702-ekf6mja9	1237	13	(	(	-LRB-
cord-006702-ekf6mja9	1237	14	37.8	37.8	CD
cord-006702-ekf6mja9	1237	15	%	%	NN
cord-006702-ekf6mja9	1237	16	)	)	-RRB-
cord-006702-ekf6mja9	1237	17	were	be	VBD
cord-006702-ekf6mja9	1237	18	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1237	19	.	.	.
cord-006702-ekf6mja9	1238	1	Cystograms	cystogram	NNS
cord-006702-ekf6mja9	1238	2	were	be	VBD
cord-006702-ekf6mja9	1238	3	performed	perform	VBN
cord-006702-ekf6mja9	1238	4	in	in	IN
cord-006702-ekf6mja9	1238	5	221	221	CD
cord-006702-ekf6mja9	1238	6	children	child	NNS
cord-006702-ekf6mja9	1238	7	,	,	,
cord-006702-ekf6mja9	1238	8	of	of	IN
cord-006702-ekf6mja9	1238	9	which	which	WDT
cord-006702-ekf6mja9	1238	10	83	83	CD
cord-006702-ekf6mja9	1238	11	(	(	-LRB-
cord-006702-ekf6mja9	1238	12	37.6	37.6	CD
cord-006702-ekf6mja9	1238	13	%	%	NN
cord-006702-ekf6mja9	1238	14	)	)	-RRB-
cord-006702-ekf6mja9	1238	15	CAKUTs	cakut	NNS
cord-006702-ekf6mja9	1238	16	were	be	VBD
cord-006702-ekf6mja9	1238	17	detected	detect	VBN
cord-006702-ekf6mja9	1238	18	;	;	:
cord-006702-ekf6mja9	1238	19	69	69	CD
cord-006702-ekf6mja9	1238	20	primary	primary	JJ
cord-006702-ekf6mja9	1238	21	VURs	vur	NNS
cord-006702-ekf6mja9	1238	22	,	,	,
cord-006702-ekf6mja9	1238	23	3	3	CD
cord-006702-ekf6mja9	1238	24	posterior	posterior	JJ
cord-006702-ekf6mja9	1238	25	urethral	urethral	JJ
cord-006702-ekf6mja9	1238	26	valves	valve	NNS
cord-006702-ekf6mja9	1238	27	,	,	,
cord-006702-ekf6mja9	1238	28	5	5	CD
cord-006702-ekf6mja9	1238	29	neurogenic	neurogenic	JJ
cord-006702-ekf6mja9	1238	30	bladders	bladder	NNS
cord-006702-ekf6mja9	1238	31	with	with	IN
cord-006702-ekf6mja9	1238	32	VUR	VUR	NNP
cord-006702-ekf6mja9	1238	33	and	and	CC
cord-006702-ekf6mja9	1238	34	4	4	CD
cord-006702-ekf6mja9	1238	35	duplex	duplex	NN
cord-006702-ekf6mja9	1238	36	kidneys	kidney	NNS
cord-006702-ekf6mja9	1238	37	and	and	CC
cord-006702-ekf6mja9	1238	38	2	2	CD
cord-006702-ekf6mja9	1238	39	urinary	urinary	JJ
cord-006702-ekf6mja9	1238	40	tract	tract	NN
cord-006702-ekf6mja9	1238	41	fistulas	fistula	NNS
cord-006702-ekf6mja9	1238	42	.	.	.
cord-006702-ekf6mja9	1239	1	108	108	CD
cord-006702-ekf6mja9	1239	2	children	child	NNS
cord-006702-ekf6mja9	1239	3	had	have	VBD
cord-006702-ekf6mja9	1239	4	a	a	DT
cord-006702-ekf6mja9	1239	5	DMSA	DMSA	NNP
cord-006702-ekf6mja9	1239	6	performed	perform	VBN
cord-006702-ekf6mja9	1239	7	,	,	,
cord-006702-ekf6mja9	1239	8	of	of	IN
cord-006702-ekf6mja9	1239	9	which	which	WDT
cord-006702-ekf6mja9	1239	10	53	53	CD
cord-006702-ekf6mja9	1239	11	(	(	-LRB-
cord-006702-ekf6mja9	1239	12	49.1	49.1	CD
cord-006702-ekf6mja9	1239	13	%	%	NN
cord-006702-ekf6mja9	1239	14	)	)	-RRB-
cord-006702-ekf6mja9	1239	15	were	be	VBD
cord-006702-ekf6mja9	1239	16	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1239	17	,	,	,
cord-006702-ekf6mja9	1239	18	including	include	VBG
cord-006702-ekf6mja9	1239	19	30	30	CD
cord-006702-ekf6mja9	1239	20	scarred	scar	VBN
cord-006702-ekf6mja9	1239	21	kidneys	kidney	NNS
cord-006702-ekf6mja9	1239	22	,	,	,
cord-006702-ekf6mja9	1239	23	14	14	CD
cord-006702-ekf6mja9	1239	24	dysplastic	dysplastic	JJ
cord-006702-ekf6mja9	1239	25	kidneys	kidney	NNS
cord-006702-ekf6mja9	1239	26	,	,	,
cord-006702-ekf6mja9	1239	27	4	4	CD
cord-006702-ekf6mja9	1239	28	with	with	IN
cord-006702-ekf6mja9	1239	29	dysplasia	dysplasia	NN
cord-006702-ekf6mja9	1239	30	and	and	CC
cord-006702-ekf6mja9	1239	31	scarring	scarring	NN
cord-006702-ekf6mja9	1239	32	in	in	IN
cord-006702-ekf6mja9	1239	33	the	the	DT
cord-006702-ekf6mja9	1239	34	contralateral	contralateral	JJ
cord-006702-ekf6mja9	1239	35	kidney	kidney	NN
cord-006702-ekf6mja9	1239	36	,	,	,
cord-006702-ekf6mja9	1239	37	2	2	CD
cord-006702-ekf6mja9	1239	38	enlarged	enlarge	VBN
cord-006702-ekf6mja9	1239	39	kidneys	kidney	NNS
cord-006702-ekf6mja9	1239	40	,	,	,
cord-006702-ekf6mja9	1239	41	2	2	CD
cord-006702-ekf6mja9	1239	42	with	with	IN
cord-006702-ekf6mja9	1239	43	generalized	generalized	JJ
cord-006702-ekf6mja9	1239	44	decreased	decrease	VBN
cord-006702-ekf6mja9	1239	45	uptake	uptake	NN
cord-006702-ekf6mja9	1239	46	in	in	IN
cord-006702-ekf6mja9	1239	47	one	one	CD
cord-006702-ekf6mja9	1239	48	kidney	kidney	NN
cord-006702-ekf6mja9	1239	49	and	and	CC
cord-006702-ekf6mja9	1239	50	1	1	CD
cord-006702-ekf6mja9	1239	51	with	with	IN
cord-006702-ekf6mja9	1239	52	a	a	DT
cord-006702-ekf6mja9	1239	53	non	non	JJ
cord-006702-ekf6mja9	1239	54	-	-	JJ
cord-006702-ekf6mja9	1239	55	functional	functional	JJ
cord-006702-ekf6mja9	1239	56	kidney	kidney	NN
cord-006702-ekf6mja9	1239	57	.	.	.
cord-006702-ekf6mja9	1240	1	Overall	overall	RB
cord-006702-ekf6mja9	1240	2	,	,	,
cord-006702-ekf6mja9	1240	3	CAKUTs	cakut	NNS
cord-006702-ekf6mja9	1240	4	were	be	VBD
cord-006702-ekf6mja9	1240	5	detected	detect	VBN
cord-006702-ekf6mja9	1240	6	in	in	IN
cord-006702-ekf6mja9	1240	7	148	148	CD
cord-006702-ekf6mja9	1240	8	(	(	-LRB-
cord-006702-ekf6mja9	1240	9	54.6	54.6	CD
cord-006702-ekf6mja9	1240	10	%	%	NN
cord-006702-ekf6mja9	1240	11	)	)	-RRB-
cord-006702-ekf6mja9	1240	12	children	child	NNS
cord-006702-ekf6mja9	1240	13	of	of	IN
cord-006702-ekf6mja9	1240	14	which	which	WDT
cord-006702-ekf6mja9	1240	15	43	43	CD
cord-006702-ekf6mja9	1240	16	were	be	VBD
cord-006702-ekf6mja9	1240	17	severe	severe	JJ
cord-006702-ekf6mja9	1240	18	and	and	CC
cord-006702-ekf6mja9	1240	19	105	105	CD
cord-006702-ekf6mja9	1240	20	were	be	VBD
cord-006702-ekf6mja9	1240	21	mild	mild	JJ
cord-006702-ekf6mja9	1240	22	.	.	.
cord-006702-ekf6mja9	1241	1	RUS	RUS	NNP
cord-006702-ekf6mja9	1241	2	together	together	RB
cord-006702-ekf6mja9	1241	3	with	with	IN
cord-006702-ekf6mja9	1241	4	cystogram	cystogram	NNP
cord-006702-ekf6mja9	1241	5	provided	provide	VBD
cord-006702-ekf6mja9	1241	6	higher	high	JJR
cord-006702-ekf6mja9	1241	7	sensitivity	sensitivity	NN
cord-006702-ekf6mja9	1241	8	(	(	-LRB-
cord-006702-ekf6mja9	1241	9	100	100	CD
cord-006702-ekf6mja9	1241	10	%	%	NN
cord-006702-ekf6mja9	1241	11	vs	vs	IN
cord-006702-ekf6mja9	1241	12	88.9	88.9	CD
cord-006702-ekf6mja9	1241	13	%	%	NN
cord-006702-ekf6mja9	1241	14	)	)	-RRB-
cord-006702-ekf6mja9	1241	15	and	and	CC
cord-006702-ekf6mja9	1241	16	specificity	specificity	NN
cord-006702-ekf6mja9	1241	17	(	(	-LRB-
cord-006702-ekf6mja9	1241	18	53.8	53.8	CD
cord-006702-ekf6mja9	1241	19	%	%	NN
cord-006702-ekf6mja9	1241	20	vs	vs	IN
cord-006702-ekf6mja9	1241	21	42.4	42.4	CD
cord-006702-ekf6mja9	1241	22	%	%	NN
cord-006702-ekf6mja9	1241	23	)	)	-RRB-
cord-006702-ekf6mja9	1241	24	to	to	TO
cord-006702-ekf6mja9	1241	25	detect	detect	VB
cord-006702-ekf6mja9	1241	26	severe	severe	JJ
cord-006702-ekf6mja9	1241	27	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1241	28	than	than	IN
cord-006702-ekf6mja9	1241	29	RUS	RUS	NNP
cord-006702-ekf6mja9	1241	30	together	together	RB
cord-006702-ekf6mja9	1241	31	with	with	IN
cord-006702-ekf6mja9	1241	32	DMSA	DMSA	NNS
cord-006702-ekf6mja9	1241	33	.	.	.
cord-006702-ekf6mja9	1242	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1242	2	:	:	:
cord-006702-ekf6mja9	1243	1	A	a	DT
cord-006702-ekf6mja9	1243	2	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1243	3	was	be	VBD
cord-006702-ekf6mja9	1243	4	detected	detect	VBN
cord-006702-ekf6mja9	1243	5	in	in	IN
cord-006702-ekf6mja9	1243	6	more	more	JJR
cord-006702-ekf6mja9	1243	7	than	than	IN
cord-006702-ekf6mja9	1243	8	half	half	NN
cord-006702-ekf6mja9	1243	9	of	of	IN
cord-006702-ekf6mja9	1243	10	the	the	DT
cord-006702-ekf6mja9	1243	11	children	child	NNS
cord-006702-ekf6mja9	1243	12	with	with	IN
cord-006702-ekf6mja9	1243	13	first	first	JJ
cord-006702-ekf6mja9	1243	14	UTI	UTI	NNP
cord-006702-ekf6mja9	1243	15	,	,	,
cord-006702-ekf6mja9	1243	16	with	with	IN
cord-006702-ekf6mja9	1243	17	one	one	CD
cord-006702-ekf6mja9	1243	18	third	third	RB
cord-006702-ekf6mja9	1243	19	having	have	VBG
cord-006702-ekf6mja9	1243	20	severe	severe	JJ
cord-006702-ekf6mja9	1243	21	CAKUT	CAKUT	NNP
cord-006702-ekf6mja9	1243	22	.	.	.
cord-006702-ekf6mja9	1244	1	There	there	EX
cord-006702-ekf6mja9	1244	2	is	be	VBZ
cord-006702-ekf6mja9	1244	3	no	no	DT
cord-006702-ekf6mja9	1244	4	single	single	JJ
cord-006702-ekf6mja9	1244	5	optimal	optimal	JJ
cord-006702-ekf6mja9	1244	6	imaging	imaging	NN
cord-006702-ekf6mja9	1244	7	study	study	NN
cord-006702-ekf6mja9	1244	8	guideline	guideline	NN
cord-006702-ekf6mja9	1244	9	after	after	IN
cord-006702-ekf6mja9	1244	10	first	first	JJ
cord-006702-ekf6mja9	1244	11	UTI	UTI	NNP
cord-006702-ekf6mja9	1244	12	,	,	,
cord-006702-ekf6mja9	1244	13	as	as	IN
cord-006702-ekf6mja9	1244	14	patient	patient	JJ
cord-006702-ekf6mja9	1244	15	settings	setting	NNS
cord-006702-ekf6mja9	1244	16	and	and	CC
cord-006702-ekf6mja9	1244	17	resources	resource	NNS
cord-006702-ekf6mja9	1244	18	vary	vary	VBP
cord-006702-ekf6mja9	1244	19	widely	widely	RB
cord-006702-ekf6mja9	1244	20	.	.	.
cord-006702-ekf6mja9	1245	1	An	an	DT
cord-006702-ekf6mja9	1245	2	open	open	JJ
cord-006702-ekf6mja9	1245	3	labelled	label	VBN
cord-006702-ekf6mja9	1245	4	Randomized	Randomized	NNP
cord-006702-ekf6mja9	1245	5	Control	Control	NNP
cord-006702-ekf6mja9	1245	6	Trial	Trial	NNP
cord-006702-ekf6mja9	1245	7	on	on	IN
cord-006702-ekf6mja9	1245	8	the	the	DT
cord-006702-ekf6mja9	1245	9	utility	utility	NN
cord-006702-ekf6mja9	1245	10	of	of	IN
cord-006702-ekf6mja9	1245	11	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1245	12	cover	cover	NN
cord-006702-ekf6mja9	1245	13	to	to	TO
cord-006702-ekf6mja9	1245	14	prevent	prevent	VB
cord-006702-ekf6mja9	1245	15	urinary	urinary	JJ
cord-006702-ekf6mja9	1245	16	tract	tract	NN
cord-006702-ekf6mja9	1245	17	infection	infection	NN
cord-006702-ekf6mja9	1245	18	in	in	IN
cord-006702-ekf6mja9	1245	19	children	child	NNS
cord-006702-ekf6mja9	1245	20	undergoing	undergo	VBG
cord-006702-ekf6mja9	1245	21	voiding	void	VBG
cord-006702-ekf6mja9	1245	22	cystouretrogram	cystouretrogram	NNP
cord-006702-ekf6mja9	1245	23	B.	B.	NNP
cord-006702-ekf6mja9	1245	24	Maji	Maji	NNP
cord-006702-ekf6mja9	1245	25	(	(	-LRB-
cord-006702-ekf6mja9	1245	26	1	1	CD
cord-006702-ekf6mja9	1245	27	)	)	-RRB-
cord-006702-ekf6mja9	1245	28	,	,	,
cord-006702-ekf6mja9	1245	29	R.	R.	NNP
cord-006702-ekf6mja9	1245	30	Sinha	Sinha	NNP
cord-006702-ekf6mja9	1245	31	(	(	-LRB-
cord-006702-ekf6mja9	1245	32	1	1	CD
cord-006702-ekf6mja9	1245	33	)	)	-RRB-
cord-006702-ekf6mja9	1245	34	,	,	,
cord-006702-ekf6mja9	1245	35	S.	S.	NNP
cord-006702-ekf6mja9	1245	36	Saha	Saha	NNP
cord-006702-ekf6mja9	1245	37	(	(	-LRB-
cord-006702-ekf6mja9	1245	38	2	2	CD
cord-006702-ekf6mja9	1245	39	)	)	-RRB-
cord-006702-ekf6mja9	1245	40	(	(	-LRB-
cord-006702-ekf6mja9	1245	41	1	1	LS
cord-006702-ekf6mja9	1245	42	)	)	-RRB-
cord-006702-ekf6mja9	1245	43	Institute	Institute	NNP
cord-006702-ekf6mja9	1245	44	of	of	IN
cord-006702-ekf6mja9	1245	45	Child	Child	NNP
cord-006702-ekf6mja9	1245	46	health	health	NN
cord-006702-ekf6mja9	1245	47	,	,	,
cord-006702-ekf6mja9	1245	48	Kolkata	Kolkata	NNP
cord-006702-ekf6mja9	1245	49	,	,	,
cord-006702-ekf6mja9	1245	50	India	India	NNP
cord-006702-ekf6mja9	1245	51	;	;	:
cord-006702-ekf6mja9	1245	52	(	(	-LRB-
cord-006702-ekf6mja9	1245	53	2	2	LS
cord-006702-ekf6mja9	1245	54	)	)	-RRB-
cord-006702-ekf6mja9	1245	55	AMRI	AMRI	NNP
cord-006702-ekf6mja9	1245	56	,	,	,
cord-006702-ekf6mja9	1245	57	Kolkata	Kolkata	NNP
cord-006702-ekf6mja9	1245	58	,	,	,
cord-006702-ekf6mja9	1245	59	India	India	NNP
cord-006702-ekf6mja9	1245	60	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1245	61	:	:	:
cord-006702-ekf6mja9	1246	1	To	to	TO
cord-006702-ekf6mja9	1246	2	conduct	conduct	VB
cord-006702-ekf6mja9	1246	3	an	an	DT
cord-006702-ekf6mja9	1246	4	open	open	JJ
cord-006702-ekf6mja9	1246	5	labelled	label	VBN
cord-006702-ekf6mja9	1246	6	randomised	randomised	JJ
cord-006702-ekf6mja9	1246	7	controlled	control	VBN
cord-006702-ekf6mja9	1246	8	trial	trial	NN
cord-006702-ekf6mja9	1246	9	to	to	TO
cord-006702-ekf6mja9	1246	10	assess	assess	VB
cord-006702-ekf6mja9	1246	11	the	the	DT
cord-006702-ekf6mja9	1246	12	utility	utility	NN
cord-006702-ekf6mja9	1246	13	of	of	IN
cord-006702-ekf6mja9	1246	14	antibiotics	antibiotic	NNS
cord-006702-ekf6mja9	1246	15	for	for	IN
cord-006702-ekf6mja9	1246	16	preventing	prevent	VBG
cord-006702-ekf6mja9	1246	17	urinary	urinary	JJ
cord-006702-ekf6mja9	1246	18	tract	tract	NN
cord-006702-ekf6mja9	1246	19	infection	infection	NN
cord-006702-ekf6mja9	1246	20	(	(	-LRB-
cord-006702-ekf6mja9	1246	21	UTI	UTI	NNP
cord-006702-ekf6mja9	1246	22	)	)	-RRB-
cord-006702-ekf6mja9	1246	23	in	in	IN
cord-006702-ekf6mja9	1246	24	children	child	NNS
cord-006702-ekf6mja9	1246	25	undergoing	undergo	VBG
cord-006702-ekf6mja9	1246	26	voiding	void	VBG
cord-006702-ekf6mja9	1246	27	cystourethrogram	cystourethrogram	NNP
cord-006702-ekf6mja9	1246	28	(	(	-LRB-
cord-006702-ekf6mja9	1246	29	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1246	30	)	)	-RRB-
cord-006702-ekf6mja9	1246	31	.	.	.
cord-006702-ekf6mja9	1247	1	Methods	method	NNS
cord-006702-ekf6mja9	1247	2	:	:	:
cord-006702-ekf6mja9	1247	3	Children	child	NNS
cord-006702-ekf6mja9	1247	4	(	(	-LRB-
cord-006702-ekf6mja9	1247	5	2	2	CD
cord-006702-ekf6mja9	1247	6	month	month	NN
cord-006702-ekf6mja9	1247	7	-5	-5	NNP
cord-006702-ekf6mja9	1247	8	year	year	NN
cord-006702-ekf6mja9	1247	9	)	)	-RRB-
cord-006702-ekf6mja9	1247	10	referred	refer	VBD
cord-006702-ekf6mja9	1247	11	for	for	IN
cord-006702-ekf6mja9	1247	12	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1247	13	were	be	VBD
cord-006702-ekf6mja9	1247	14	confirmed	confirm	VBN
cord-006702-ekf6mja9	1247	15	to	to	TO
cord-006702-ekf6mja9	1247	16	have	have	VB
cord-006702-ekf6mja9	1247	17	sterile	sterile	JJ
cord-006702-ekf6mja9	1247	18	urine	urine	NN
cord-006702-ekf6mja9	1247	19	and	and	CC
cord-006702-ekf6mja9	1247	20	were	be	VBD
cord-006702-ekf6mja9	1247	21	thereafter	thereafter	RB
cord-006702-ekf6mja9	1247	22	randomized	randomize	VBN
cord-006702-ekf6mja9	1247	23	in	in	IN
cord-006702-ekf6mja9	1247	24	3:2	3:2	CD
cord-006702-ekf6mja9	1247	25	ratios	ratio	NNS
cord-006702-ekf6mja9	1247	26	to	to	IN
cord-006702-ekf6mja9	1247	27	either	either	CC
cord-006702-ekf6mja9	1247	28	undergo	undergo	VB
cord-006702-ekf6mja9	1247	29	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1247	30	under	under	IN
cord-006702-ekf6mja9	1247	31	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1247	32	cover	cover	NN
cord-006702-ekf6mja9	1247	33	(	(	-LRB-
cord-006702-ekf6mja9	1247	34	cotrimoxazole	cotrimoxazole	NN
cord-006702-ekf6mja9	1247	35	or	or	CC
cord-006702-ekf6mja9	1247	36	cephalexin	cephalexin	NNP
cord-006702-ekf6mja9	1247	37	was	be	VBD
cord-006702-ekf6mja9	1247	38	started	start	VBN
cord-006702-ekf6mja9	1247	39	a	a	DT
cord-006702-ekf6mja9	1247	40	day	day	NN
cord-006702-ekf6mja9	1247	41	prior	prior	JJ
cord-006702-ekf6mja9	1247	42	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1247	43	and	and	CC
cord-006702-ekf6mja9	1247	44	continued	continue	VBD
cord-006702-ekf6mja9	1247	45	for	for	IN
cord-006702-ekf6mja9	1247	46	a	a	DT
cord-006702-ekf6mja9	1247	47	day	day	NN
cord-006702-ekf6mja9	1247	48	post	post	NN
cord-006702-ekf6mja9	1247	49	procedure	procedure	NN
cord-006702-ekf6mja9	1247	50	)	)	-RRB-
cord-006702-ekf6mja9	1247	51	or	or	CC
cord-006702-ekf6mja9	1247	52	without	without	IN
cord-006702-ekf6mja9	1247	53	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1247	54	cover	cover	NN
cord-006702-ekf6mja9	1247	55	.	.	.
cord-006702-ekf6mja9	1248	1	Sample	sample	JJ
cord-006702-ekf6mja9	1248	2	size	size	NN
cord-006702-ekf6mja9	1248	3	was	be	VBD
cord-006702-ekf6mja9	1248	4	calculated	calculate	VBN
cord-006702-ekf6mja9	1248	5	at	at	IN
cord-006702-ekf6mja9	1248	6	120	120	CD
cord-006702-ekf6mja9	1248	7	for	for	IN
cord-006702-ekf6mja9	1248	8	a	a	DT
cord-006702-ekf6mja9	1248	9	power	power	NN
cord-006702-ekf6mja9	1248	10	of	of	IN
cord-006702-ekf6mja9	1248	11	80	80	CD
cord-006702-ekf6mja9	1248	12	%	%	NN
cord-006702-ekf6mja9	1248	13	with	with	IN
cord-006702-ekf6mja9	1248	14	alpha	alpha	NN
cord-006702-ekf6mja9	1248	15	0.05	0.05	CD
cord-006702-ekf6mja9	1248	16	.	.	.
cord-006702-ekf6mja9	1249	1	Urine	urine	NN
cord-006702-ekf6mja9	1249	2	routine	routine	NN
cord-006702-ekf6mja9	1249	3	and	and	CC
cord-006702-ekf6mja9	1249	4	culture	culture	NN
cord-006702-ekf6mja9	1249	5	was	be	VBD
cord-006702-ekf6mja9	1249	6	done	do	VBN
cord-006702-ekf6mja9	1249	7	4	4	CD
cord-006702-ekf6mja9	1249	8	days	day	NNS
cord-006702-ekf6mja9	1249	9	prior	prior	IN
cord-006702-ekf6mja9	1249	10	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1249	11	to	to	TO
cord-006702-ekf6mja9	1249	12	rule	rule	VB
cord-006702-ekf6mja9	1249	13	out	out	RP
cord-006702-ekf6mja9	1249	14	underlying	underlie	VBG
cord-006702-ekf6mja9	1249	15	UTI	UTI	NNP
cord-006702-ekf6mja9	1249	16	and	and	CC
cord-006702-ekf6mja9	1249	17	repeated	repeat	VBN
cord-006702-ekf6mja9	1250	1	2	2	CD
cord-006702-ekf6mja9	1250	2	days	day	NNS
cord-006702-ekf6mja9	1250	3	post	post	VBP
cord-006702-ekf6mja9	1250	4	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1250	5	to	to	TO
cord-006702-ekf6mja9	1250	6	diagnose	diagnose	VB
cord-006702-ekf6mja9	1250	7	post	post	NN
cord-006702-ekf6mja9	1250	8	procedure	procedure	NN
cord-006702-ekf6mja9	1250	9	UTI	UTI	NNP
cord-006702-ekf6mja9	1250	10	.	.	.
cord-006702-ekf6mja9	1251	1	Results	result	NNS
cord-006702-ekf6mja9	1251	2	:	:	:
cord-006702-ekf6mja9	1251	3	120	120	CD
cord-006702-ekf6mja9	1251	4	children	child	NNS
cord-006702-ekf6mja9	1251	5	(	(	-LRB-
cord-006702-ekf6mja9	1251	6	69	69	CD
cord-006702-ekf6mja9	1251	7	%	%	NN
cord-006702-ekf6mja9	1251	8	male	male	NN
cord-006702-ekf6mja9	1251	9	,	,	,
cord-006702-ekf6mja9	1251	10	age	age	NN
cord-006702-ekf6mja9	1251	11	:	:	:
cord-006702-ekf6mja9	1251	12	median	median	NN
cord-006702-ekf6mja9	1251	13	10	10	CD
cord-006702-ekf6mja9	1251	14	month	month	NN
cord-006702-ekf6mja9	1251	15	,	,	,
cord-006702-ekf6mja9	1251	16	range	range	VBP
cord-006702-ekf6mja9	1251	17	2	2	CD
cord-006702-ekf6mja9	1251	18	to	to	TO
cord-006702-ekf6mja9	1251	19	60	60	CD
cord-006702-ekf6mja9	1251	20	months	month	NNS
cord-006702-ekf6mja9	1251	21	)	)	-RRB-
cord-006702-ekf6mja9	1251	22	were	be	VBD
cord-006702-ekf6mja9	1251	23	recruited	recruit	VBN
cord-006702-ekf6mja9	1251	24	.	.	.
cord-006702-ekf6mja9	1252	1	No	no	DT
cord-006702-ekf6mja9	1252	2	significant	significant	JJ
cord-006702-ekf6mja9	1252	3	difference	difference	NN
cord-006702-ekf6mja9	1252	4	was	be	VBD
cord-006702-ekf6mja9	1252	5	noted	note	VBN
cord-006702-ekf6mja9	1252	6	in	in	IN
cord-006702-ekf6mja9	1252	7	the	the	DT
cord-006702-ekf6mja9	1252	8	demographic	demographic	JJ
cord-006702-ekf6mja9	1252	9	criteria	criterion	NNS
cord-006702-ekf6mja9	1252	10	between	between	IN
cord-006702-ekf6mja9	1252	11	those	those	DT
cord-006702-ekf6mja9	1252	12	receiving	receive	VBG
cord-006702-ekf6mja9	1252	13	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1252	14	(	(	-LRB-
cord-006702-ekf6mja9	1252	15	n=72	n=72	NN
cord-006702-ekf6mja9	1252	16	)	)	-RRB-
cord-006702-ekf6mja9	1252	17	and	and	CC
cord-006702-ekf6mja9	1252	18	not	not	RB
cord-006702-ekf6mja9	1252	19	receiving	receive	VBG
cord-006702-ekf6mja9	1252	20	antibiotic	antibiotic	NN
cord-006702-ekf6mja9	1252	21	(	(	-LRB-
cord-006702-ekf6mja9	1252	22	n=48	n=48	NN
cord-006702-ekf6mja9	1252	23	)	)	-RRB-
cord-006702-ekf6mja9	1252	24	.	.	.
cord-006702-ekf6mja9	1253	1	Overall	overall	JJ
cord-006702-ekf6mja9	1253	2	13	13	CD
cord-006702-ekf6mja9	1253	3	children	child	NNS
cord-006702-ekf6mja9	1253	4	(	(	-LRB-
cord-006702-ekf6mja9	1253	5	11	11	CD
cord-006702-ekf6mja9	1253	6	%	%	NN
cord-006702-ekf6mja9	1253	7	)	)	-RRB-
cord-006702-ekf6mja9	1253	8	developed	develop	VBN
cord-006702-ekf6mja9	1253	9	post	post	NN
cord-006702-ekf6mja9	1253	10	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1253	11	UTI	UTI	NNP
cord-006702-ekf6mja9	1253	12	.	.	.
cord-006702-ekf6mja9	1254	1	Incidence	incidence	NN
cord-006702-ekf6mja9	1254	2	of	of	IN
cord-006702-ekf6mja9	1254	3	UTI	UTI	NNP
cord-006702-ekf6mja9	1254	4	was	be	VBD
cord-006702-ekf6mja9	1254	5	significantly	significantly	RB
cord-006702-ekf6mja9	1254	6	lower	low	JJR
cord-006702-ekf6mja9	1254	7	among	among	IN
cord-006702-ekf6mja9	1254	8	those	those	DT
cord-006702-ekf6mja9	1254	9	receiving	receive	VBG
cord-006702-ekf6mja9	1254	10	antibiotic	antibiotic	NN
cord-006702-ekf6mja9	1254	11	(	(	-LRB-
cord-006702-ekf6mja9	1254	12	n=	n=	NNP
cord-006702-ekf6mja9	1254	13	4	4	CD
cord-006702-ekf6mja9	1254	14	,	,	,
cord-006702-ekf6mja9	1254	15	6	6	CD
cord-006702-ekf6mja9	1254	16	%	%	NN
cord-006702-ekf6mja9	1254	17	)	)	-RRB-
cord-006702-ekf6mja9	1255	1	when	when	WRB
cord-006702-ekf6mja9	1255	2	compared	compare	VBN
cord-006702-ekf6mja9	1255	3	to	to	IN
cord-006702-ekf6mja9	1255	4	those	those	DT
cord-006702-ekf6mja9	1255	5	not	not	RB
cord-006702-ekf6mja9	1255	6	receiving	receive	VBG
cord-006702-ekf6mja9	1255	7	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1255	8	(	(	-LRB-
cord-006702-ekf6mja9	1255	9	n=9	n=9	NN
cord-006702-ekf6mja9	1255	10	,	,	,
cord-006702-ekf6mja9	1255	11	19	19	CD
cord-006702-ekf6mja9	1255	12	%	%	NN
cord-006702-ekf6mja9	1255	13	)	)	-RRB-
cord-006702-ekf6mja9	1255	14	,	,	,
cord-006702-ekf6mja9	1255	15	p=0.02	p=0.02	NNP
cord-006702-ekf6mja9	1255	16	.	.	.
cord-006702-ekf6mja9	1256	1	21	21	CD
cord-006702-ekf6mja9	1256	2	%	%	NN
cord-006702-ekf6mja9	1256	3	(	(	-LRB-
cord-006702-ekf6mja9	1256	4	n=10	n=10	NNP
cord-006702-ekf6mja9	1256	5	)	)	-RRB-
cord-006702-ekf6mja9	1256	6	of	of	IN
cord-006702-ekf6mja9	1256	7	children	child	NNS
cord-006702-ekf6mja9	1256	8	with	with	IN
cord-006702-ekf6mja9	1256	9	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1256	10	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	1256	11	(	(	-LRB-
cord-006702-ekf6mja9	1256	12	n=48	n=48	NN
cord-006702-ekf6mja9	1256	13	)	)	-RRB-
cord-006702-ekf6mja9	1256	14	developed	develop	VBD
cord-006702-ekf6mja9	1256	15	UTI	UTI	NNP
cord-006702-ekf6mja9	1256	16	post	post	NN
cord-006702-ekf6mja9	1256	17	VCUG	vcug	NN
cord-006702-ekf6mja9	1256	18	when	when	WRB
cord-006702-ekf6mja9	1256	19	compared	compare	VBN
cord-006702-ekf6mja9	1256	20	to	to	IN
cord-006702-ekf6mja9	1256	21	4	4	CD
cord-006702-ekf6mja9	1256	22	%	%	NN
cord-006702-ekf6mja9	1256	23	(	(	-LRB-
cord-006702-ekf6mja9	1256	24	n=3	n=3	NN
cord-006702-ekf6mja9	1256	25	)	)	-RRB-
cord-006702-ekf6mja9	1256	26	of	of	IN
cord-006702-ekf6mja9	1256	27	children	child	NNS
cord-006702-ekf6mja9	1256	28	with	with	IN
cord-006702-ekf6mja9	1256	29	normal	normal	JJ
cord-006702-ekf6mja9	1256	30	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	1256	31	(	(	-LRB-
cord-006702-ekf6mja9	1256	32	n=72	n=72	NN
cord-006702-ekf6mja9	1256	33	)	)	-RRB-
cord-006702-ekf6mja9	1256	34	p	p	NN
cord-006702-ekf6mja9	1256	35	=	=	SYM
cord-006702-ekf6mja9	1256	36	0.004	0.004	CD
cord-006702-ekf6mja9	1256	37	.	.	.
cord-006702-ekf6mja9	1257	1	The	the	DT
cord-006702-ekf6mja9	1257	2	RCT	RCT	NNP
cord-006702-ekf6mja9	1257	3	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	1257	4	that	that	IN
cord-006702-ekf6mja9	1257	5	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1257	6	performed	perform	VBN
cord-006702-ekf6mja9	1257	7	under	under	IN
cord-006702-ekf6mja9	1257	8	antibiotic	antibiotic	JJ
cord-006702-ekf6mja9	1257	9	cover	cover	NN
cord-006702-ekf6mja9	1257	10	results	result	NNS
cord-006702-ekf6mja9	1257	11	in	in	IN
cord-006702-ekf6mja9	1257	12	significantly	significantly	RB
cord-006702-ekf6mja9	1257	13	less	less	JJR
cord-006702-ekf6mja9	1257	14	UTI	UTI	NNP
cord-006702-ekf6mja9	1257	15	.	.	.
cord-006702-ekf6mja9	1258	1	It	-PRON-	PRP
cord-006702-ekf6mja9	1258	2	also	also	RB
cord-006702-ekf6mja9	1258	3	revealed	reveal	VBD
cord-006702-ekf6mja9	1258	4	that	that	IN
cord-006702-ekf6mja9	1258	5	risk	risk	NN
cord-006702-ekf6mja9	1258	6	of	of	IN
cord-006702-ekf6mja9	1258	7	post	post	FW
cord-006702-ekf6mja9	1258	8	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1258	9	UTI	UTI	NNP
cord-006702-ekf6mja9	1258	10	is	be	VBZ
cord-006702-ekf6mja9	1258	11	significantly	significantly	RB
cord-006702-ekf6mja9	1258	12	higher	high	JJR
cord-006702-ekf6mja9	1258	13	among	among	IN
cord-006702-ekf6mja9	1258	14	those	those	DT
cord-006702-ekf6mja9	1258	15	with	with	IN
cord-006702-ekf6mja9	1258	16	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1258	17	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	1258	18	.	.	.
cord-006702-ekf6mja9	1259	1	Future	future	JJ
cord-006702-ekf6mja9	1259	2	studies	study	NNS
cord-006702-ekf6mja9	1259	3	are	be	VBP
cord-006702-ekf6mja9	1259	4	needed	need	VBN
cord-006702-ekf6mja9	1259	5	to	to	TO
cord-006702-ekf6mja9	1259	6	explore	explore	VB
cord-006702-ekf6mja9	1259	7	whether	whether	IN
cord-006702-ekf6mja9	1259	8	using	use	VBG
cord-006702-ekf6mja9	1259	9	antibiotic	antibiotic	NN
cord-006702-ekf6mja9	1259	10	only	only	RB
cord-006702-ekf6mja9	1259	11	among	among	IN
cord-006702-ekf6mja9	1259	12	those	those	DT
cord-006702-ekf6mja9	1259	13	with	with	IN
cord-006702-ekf6mja9	1259	14	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1259	15	ultrasound	ultrasound	NN
cord-006702-ekf6mja9	1259	16	will	will	MD
cord-006702-ekf6mja9	1259	17	reduce	reduce	VB
cord-006702-ekf6mja9	1259	18	the	the	DT
cord-006702-ekf6mja9	1259	19	usage	usage	NN
cord-006702-ekf6mja9	1259	20	of	of	IN
cord-006702-ekf6mja9	1259	21	antibiotic	antibiotic	NN
cord-006702-ekf6mja9	1259	22	without	without	IN
cord-006702-ekf6mja9	1259	23	increasing	increase	VBG
cord-006702-ekf6mja9	1259	24	the	the	DT
cord-006702-ekf6mja9	1259	25	risk	risk	NN
cord-006702-ekf6mja9	1259	26	for	for	IN
cord-006702-ekf6mja9	1259	27	post	post	FW
cord-006702-ekf6mja9	1259	28	VCUG	VCUG	NNP
cord-006702-ekf6mja9	1259	29	UTI	UTI	NNP
cord-006702-ekf6mja9	1259	30	.	.	.
cord-006702-ekf6mja9	1260	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1260	2	:	:	:
cord-006702-ekf6mja9	1261	1	The	the	DT
cord-006702-ekf6mja9	1261	2	incidence	incidence	NN
cord-006702-ekf6mja9	1261	3	of	of	IN
cord-006702-ekf6mja9	1261	4	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1261	5	urolithiasis	urolithiasis	NN
cord-006702-ekf6mja9	1261	6	is	be	VBZ
cord-006702-ekf6mja9	1261	7	rising	rise	VBG
cord-006702-ekf6mja9	1261	8	in	in	IN
cord-006702-ekf6mja9	1261	9	the	the	DT
cord-006702-ekf6mja9	1261	10	UK	UK	NNP
cord-006702-ekf6mja9	1261	11	,	,	,
cord-006702-ekf6mja9	1261	12	with	with	IN
cord-006702-ekf6mja9	1261	13	increasing	increase	VBG
cord-006702-ekf6mja9	1261	14	older	old	JJR
cord-006702-ekf6mja9	1261	15	children	child	NNS
cord-006702-ekf6mja9	1261	16	and	and	CC
cord-006702-ekf6mja9	1261	17	females	female	NNS
cord-006702-ekf6mja9	1261	18	.	.	.
cord-006702-ekf6mja9	1262	1	Metabolic	metabolic	JJ
cord-006702-ekf6mja9	1262	2	abnormalities	abnormality	NNS
cord-006702-ekf6mja9	1262	3	commonly	commonly	RB
cord-006702-ekf6mja9	1262	4	predispose	predispose	VBP
cord-006702-ekf6mja9	1262	5	urolithiasis	urolithiasis	NN
cord-006702-ekf6mja9	1262	6	and	and	CC
cord-006702-ekf6mja9	1262	7	recurrence	recurrence	NN
cord-006702-ekf6mja9	1262	8	rates	rate	NNS
cord-006702-ekf6mja9	1262	9	are	be	VBP
cord-006702-ekf6mja9	1262	10	high	high	JJ
cord-006702-ekf6mja9	1262	11	,	,	,
cord-006702-ekf6mja9	1262	12	justifying	justify	VBG
cord-006702-ekf6mja9	1262	13	the	the	DT
cord-006702-ekf6mja9	1262	14	comprehensive	comprehensive	JJ
cord-006702-ekf6mja9	1262	15	screening	screening	NN
cord-006702-ekf6mja9	1262	16	of	of	IN
cord-006702-ekf6mja9	1262	17	all	all	DT
cord-006702-ekf6mja9	1262	18	children	child	NNS
cord-006702-ekf6mja9	1262	19	.	.	.
cord-006702-ekf6mja9	1263	1	Objectives	objective	NNS
cord-006702-ekf6mja9	1263	2	:	:	:
cord-006702-ekf6mja9	1263	3	We	-PRON-	PRP
cord-006702-ekf6mja9	1263	4	report	report	VBP
cord-006702-ekf6mja9	1263	5	preliminary	preliminary	JJ
cord-006702-ekf6mja9	1263	6	observations	observation	NNS
cord-006702-ekf6mja9	1263	7	from	from	IN
cord-006702-ekf6mja9	1263	8	a	a	DT
cord-006702-ekf6mja9	1263	9	first	first	JJ
cord-006702-ekf6mja9	1263	10	-	-	HYPH
cord-006702-ekf6mja9	1263	11	in	in	IN
cord-006702-ekf6mja9	1263	12	-	-	HYPH
cord-006702-ekf6mja9	1263	13	human	human	JJ
cord-006702-ekf6mja9	1263	14	clinical	clinical	JJ
cord-006702-ekf6mja9	1263	15	trial	trial	NN
cord-006702-ekf6mja9	1263	16	of	of	IN
cord-006702-ekf6mja9	1263	17	ALN	ALN	NNP
cord-006702-ekf6mja9	1263	18	-	-	HYPH
cord-006702-ekf6mja9	1263	19	GO1	GO1	NNP
cord-006702-ekf6mja9	1263	20	,	,	,
cord-006702-ekf6mja9	1263	21	a	a	DT
cord-006702-ekf6mja9	1263	22	subcutaneously	subcutaneously	RB
cord-006702-ekf6mja9	1263	23	administered	administer	VBN
cord-006702-ekf6mja9	1263	24	investigational	investigational	JJ
cord-006702-ekf6mja9	1263	25	small	small	JJ
cord-006702-ekf6mja9	1263	26	interfering	interfere	VBG
cord-006702-ekf6mja9	1263	27	RNA	RNA	NNP
cord-006702-ekf6mja9	1263	28	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	1263	29	for	for	IN
cord-006702-ekf6mja9	1263	30	the	the	DT
cord-006702-ekf6mja9	1263	31	treatment	treatment	NN
cord-006702-ekf6mja9	1263	32	of	of	IN
cord-006702-ekf6mja9	1263	33	primary	primary	JJ
cord-006702-ekf6mja9	1263	34	hyperoxaluria	hyperoxaluria	NNP
cord-006702-ekf6mja9	1263	35	type	type	NN
cord-006702-ekf6mja9	1263	36	1	1	CD
cord-006702-ekf6mja9	1263	37	(	(	-LRB-
cord-006702-ekf6mja9	1263	38	PH1	PH1	NNP
cord-006702-ekf6mja9	1263	39	)	)	-RRB-
cord-006702-ekf6mja9	1263	40	.	.	.
cord-006702-ekf6mja9	1264	1	PH1	PH1	NNP
cord-006702-ekf6mja9	1264	2	is	be	VBZ
cord-006702-ekf6mja9	1264	3	a	a	DT
cord-006702-ekf6mja9	1264	4	rare	rare	JJ
cord-006702-ekf6mja9	1264	5	,	,	,
cord-006702-ekf6mja9	1264	6	inherited	inherit	VBN
cord-006702-ekf6mja9	1264	7	,	,	,
cord-006702-ekf6mja9	1264	8	life	life	NN
cord-006702-ekf6mja9	1264	9	threatening	threaten	VBG
cord-006702-ekf6mja9	1264	10	condition	condition	NN
cord-006702-ekf6mja9	1264	11	characterized	characterize	VBN
cord-006702-ekf6mja9	1264	12	by	by	IN
cord-006702-ekf6mja9	1264	13	end	end	NN
cord-006702-ekf6mja9	1264	14	stage	stage	NN
cord-006702-ekf6mja9	1264	15	renal	renal	JJ
cord-006702-ekf6mja9	1264	16	disease	disease	NN
cord-006702-ekf6mja9	1264	17	and	and	CC
cord-006702-ekf6mja9	1264	18	multiple	multiple	JJ
cord-006702-ekf6mja9	1264	19	end	end	NN
cord-006702-ekf6mja9	1264	20	organ	organ	NN
cord-006702-ekf6mja9	1264	21	damage	damage	NN
cord-006702-ekf6mja9	1264	22	.	.	.
cord-006702-ekf6mja9	1265	1	The	the	DT
cord-006702-ekf6mja9	1265	2	disease	disease	NN
cord-006702-ekf6mja9	1265	3	results	result	VBZ
cord-006702-ekf6mja9	1265	4	from	from	IN
cord-006702-ekf6mja9	1265	5	an	an	DT
cord-006702-ekf6mja9	1265	6	inherited	inherit	VBN
cord-006702-ekf6mja9	1265	7	defect	defect	NN
cord-006702-ekf6mja9	1265	8	in	in	IN
cord-006702-ekf6mja9	1265	9	the	the	DT
cord-006702-ekf6mja9	1265	10	hepatic	hepatic	JJ
cord-006702-ekf6mja9	1265	11	peroxisomal	peroxisomal	JJ
cord-006702-ekf6mja9	1265	12	enzyme	enzyme	NN
cord-006702-ekf6mja9	1265	13	,	,	,
cord-006702-ekf6mja9	1265	14	alanine	alanine	NNP
cord-006702-ekf6mja9	1265	15	glyoxylate	glyoxylate	NNP
cord-006702-ekf6mja9	1265	16	aminotransferase	aminotransferase	NN
cord-006702-ekf6mja9	1265	17	(	(	-LRB-
cord-006702-ekf6mja9	1265	18	AGXT	AGXT	NNP
cord-006702-ekf6mja9	1265	19	)	)	-RRB-
cord-006702-ekf6mja9	1265	20	,	,	,
cord-006702-ekf6mja9	1265	21	causing	cause	VBG
cord-006702-ekf6mja9	1265	22	an	an	DT
cord-006702-ekf6mja9	1265	23	overproduction	overproduction	NN
cord-006702-ekf6mja9	1265	24	of	of	IN
cord-006702-ekf6mja9	1265	25	the	the	DT
cord-006702-ekf6mja9	1265	26	toxic	toxic	JJ
cord-006702-ekf6mja9	1265	27	metabolite	metabolite	NN
cord-006702-ekf6mja9	1265	28	,	,	,
cord-006702-ekf6mja9	1265	29	oxalate	oxalate	NN
cord-006702-ekf6mja9	1265	30	.	.	.
cord-006702-ekf6mja9	1266	1	Currently	currently	RB
cord-006702-ekf6mja9	1266	2	,	,	,
cord-006702-ekf6mja9	1266	3	liver	liver	NN
cord-006702-ekf6mja9	1266	4	transplantation	transplantation	NN
cord-006702-ekf6mja9	1266	5	provides	provide	VBZ
cord-006702-ekf6mja9	1266	6	the	the	DT
cord-006702-ekf6mja9	1266	7	only	only	JJ
cord-006702-ekf6mja9	1266	8	definitive	definitive	JJ
cord-006702-ekf6mja9	1266	9	correction	correction	NN
cord-006702-ekf6mja9	1266	10	of	of	IN
cord-006702-ekf6mja9	1266	11	the	the	DT
cord-006702-ekf6mja9	1266	12	hepatic	hepatic	JJ
cord-006702-ekf6mja9	1266	13	metabolic	metabolic	JJ
cord-006702-ekf6mja9	1266	14	defect	defect	NN
cord-006702-ekf6mja9	1266	15	.	.	.
cord-006702-ekf6mja9	1267	1	ALN	ALN	NNP
cord-006702-ekf6mja9	1267	2	-	-	HYPH
cord-006702-ekf6mja9	1267	3	GO1	GO1	NNP
cord-006702-ekf6mja9	1267	4	is	be	VBZ
cord-006702-ekf6mja9	1267	5	targeted	target	VBN
cord-006702-ekf6mja9	1267	6	to	to	IN
cord-006702-ekf6mja9	1267	7	hepatocytes	hepatocyte	NNS
cord-006702-ekf6mja9	1267	8	,	,	,
cord-006702-ekf6mja9	1267	9	where	where	WRB
cord-006702-ekf6mja9	1267	10	it	-PRON-	PRP
cord-006702-ekf6mja9	1267	11	inhibits	inhibit	VBZ
cord-006702-ekf6mja9	1267	12	glycolate	glycolate	JJ
cord-006702-ekf6mja9	1267	13	oxidase	oxidase	NN
cord-006702-ekf6mja9	1267	14	(	(	-LRB-
cord-006702-ekf6mja9	1267	15	GO	GO	NNP
cord-006702-ekf6mja9	1267	16	)	)	-RRB-
cord-006702-ekf6mja9	1267	17	,	,	,
cord-006702-ekf6mja9	1267	18	an	an	DT
cord-006702-ekf6mja9	1267	19	enzyme	enzyme	NN
cord-006702-ekf6mja9	1267	20	upstream	upstream	RB
cord-006702-ekf6mja9	1267	21	of	of	IN
cord-006702-ekf6mja9	1267	22	AGT	AGT	NNP
cord-006702-ekf6mja9	1267	23	,	,	,
cord-006702-ekf6mja9	1267	24	thereby	thereby	RB
cord-006702-ekf6mja9	1267	25	reducing	reduce	VBG
cord-006702-ekf6mja9	1267	26	the	the	DT
cord-006702-ekf6mja9	1267	27	substrate	substrate	NN
cord-006702-ekf6mja9	1267	28	for	for	IN
cord-006702-ekf6mja9	1267	29	oxalate	oxalate	NN
cord-006702-ekf6mja9	1267	30	production	production	NN
cord-006702-ekf6mja9	1267	31	.	.	.
cord-006702-ekf6mja9	1268	1	In	in	IN
cord-006702-ekf6mja9	1268	2	pre	pre	JJ
cord-006702-ekf6mja9	1268	3	-	-	JJ
cord-006702-ekf6mja9	1268	4	clinical	clinical	JJ
cord-006702-ekf6mja9	1268	5	models	model	NNS
cord-006702-ekf6mja9	1268	6	,	,	,
cord-006702-ekf6mja9	1268	7	treatment	treatment	NN
cord-006702-ekf6mja9	1268	8	with	with	IN
cord-006702-ekf6mja9	1268	9	ALN	ALN	NNP
cord-006702-ekf6mja9	1268	10	-	-	HYPH
cord-006702-ekf6mja9	1268	11	GO1	GO1	NNP
cord-006702-ekf6mja9	1268	12	has	have	VBZ
cord-006702-ekf6mja9	1268	13	demonstrated	demonstrate	VBN
cord-006702-ekf6mja9	1268	14	a	a	DT
cord-006702-ekf6mja9	1268	15	dose	dose	NN
cord-006702-ekf6mja9	1268	16	-	-	HYPH
cord-006702-ekf6mja9	1268	17	dependent	dependent	JJ
cord-006702-ekf6mja9	1268	18	increase	increase	NN
cord-006702-ekf6mja9	1268	19	in	in	IN
cord-006702-ekf6mja9	1268	20	the	the	DT
cord-006702-ekf6mja9	1268	21	non	non	JJ
cord-006702-ekf6mja9	1268	22	-	-	JJ
cord-006702-ekf6mja9	1268	23	toxic	toxic	JJ
cord-006702-ekf6mja9	1268	24	metabolite	metabolite	NN
cord-006702-ekf6mja9	1268	25	,	,	,
cord-006702-ekf6mja9	1268	26	glycolate	glycolate	NNP
cord-006702-ekf6mja9	1268	27	,	,	,
cord-006702-ekf6mja9	1268	28	with	with	IN
cord-006702-ekf6mja9	1268	29	a	a	DT
cord-006702-ekf6mja9	1268	30	corresponding	corresponding	JJ
cord-006702-ekf6mja9	1268	31	reduction	reduction	NN
cord-006702-ekf6mja9	1268	32	in	in	IN
cord-006702-ekf6mja9	1268	33	oxalate	oxalate	NN
cord-006702-ekf6mja9	1268	34	excretion	excretion	NN
cord-006702-ekf6mja9	1268	35	,	,	,
cord-006702-ekf6mja9	1268	36	suggesting	suggest	VBG
cord-006702-ekf6mja9	1268	37	a	a	DT
cord-006702-ekf6mja9	1268	38	potential	potential	NN
cord-006702-ekf6mja9	1268	39	for	for	IN
cord-006702-ekf6mja9	1268	40	therapeutic	therapeutic	JJ
cord-006702-ekf6mja9	1268	41	benefit	benefit	NN
cord-006702-ekf6mja9	1268	42	.	.	.
cord-006702-ekf6mja9	1269	1	Methods	method	NNS
cord-006702-ekf6mja9	1269	2	:	:	:
cord-006702-ekf6mja9	1270	1	A	a	DT
cord-006702-ekf6mja9	1270	2	placebo	placebo	NN
cord-006702-ekf6mja9	1270	3	-	-	HYPH
cord-006702-ekf6mja9	1270	4	controlled	control	VBN
cord-006702-ekf6mja9	1270	5	single	single	RB
cord-006702-ekf6mja9	1270	6	-	-	HYPH
cord-006702-ekf6mja9	1270	7	ascending	ascend	VBG
cord-006702-ekf6mja9	1270	8	dose	dose	NN
cord-006702-ekf6mja9	1270	9	Phase	phase	NN
cord-006702-ekf6mja9	1270	10	1/2	1/2	CD
cord-006702-ekf6mja9	1270	11	study	study	NN
cord-006702-ekf6mja9	1270	12	of	of	IN
cord-006702-ekf6mja9	1270	13	ALN	ALN	NNP
cord-006702-ekf6mja9	1270	14	-	-	HYPH
cord-006702-ekf6mja9	1270	15	GO1	GO1	NNP
cord-006702-ekf6mja9	1270	16	is	be	VBZ
cord-006702-ekf6mja9	1270	17	ongoing	ongoing	JJ
cord-006702-ekf6mja9	1270	18	in	in	IN
cord-006702-ekf6mja9	1270	19	healthy	healthy	JJ
cord-006702-ekf6mja9	1270	20	adult	adult	NN
cord-006702-ekf6mja9	1270	21	volunteers	volunteer	NNS
cord-006702-ekf6mja9	1270	22	.	.	.
cord-006702-ekf6mja9	1271	1	The	the	DT
cord-006702-ekf6mja9	1271	2	primary	primary	JJ
cord-006702-ekf6mja9	1271	3	endpoint	endpoint	NN
cord-006702-ekf6mja9	1271	4	is	be	VBZ
cord-006702-ekf6mja9	1271	5	safety	safety	NN
cord-006702-ekf6mja9	1271	6	and	and	CC
cord-006702-ekf6mja9	1271	7	tolerability	tolerability	NN
cord-006702-ekf6mja9	1271	8	.	.	.
cord-006702-ekf6mja9	1272	1	Changes	change	NNS
cord-006702-ekf6mja9	1272	2	in	in	IN
cord-006702-ekf6mja9	1272	3	plasma	plasma	NN
cord-006702-ekf6mja9	1272	4	glycolate	glycolate	NN
cord-006702-ekf6mja9	1272	5	to	to	TO
cord-006702-ekf6mja9	1272	6	determine	determine	VB
cord-006702-ekf6mja9	1272	7	selection	selection	NN
cord-006702-ekf6mja9	1272	8	optimum	optimum	JJ
cord-006702-ekf6mja9	1272	9	dosing	dosing	NN
cord-006702-ekf6mja9	1272	10	regimens	regimen	NNS
cord-006702-ekf6mja9	1272	11	for	for	IN
cord-006702-ekf6mja9	1272	12	patients	patient	NNS
cord-006702-ekf6mja9	1272	13	with	with	IN
cord-006702-ekf6mja9	1272	14	PH1	PH1	NNP
cord-006702-ekf6mja9	1272	15	will	will	MD
cord-006702-ekf6mja9	1272	16	also	also	RB
cord-006702-ekf6mja9	1272	17	be	be	VB
cord-006702-ekf6mja9	1272	18	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1272	19	.	.	.
cord-006702-ekf6mja9	1273	1	Results	result	NNS
cord-006702-ekf6mja9	1273	2	:	:	:
cord-006702-ekf6mja9	1273	3	Safety	safety	NN
cord-006702-ekf6mja9	1273	4	,	,	,
cord-006702-ekf6mja9	1273	5	tolerability	tolerability	NN
cord-006702-ekf6mja9	1273	6	and	and	CC
cord-006702-ekf6mja9	1273	7	emerging	emerge	VBG
cord-006702-ekf6mja9	1273	8	dose	dose	NN
cord-006702-ekf6mja9	1273	9	-	-	HYPH
cord-006702-ekf6mja9	1273	10	dependent	dependent	JJ
cord-006702-ekf6mja9	1273	11	pharmacodynamic	pharmacodynamic	JJ
cord-006702-ekf6mja9	1273	12	data	datum	NNS
cord-006702-ekf6mja9	1273	13	will	will	MD
cord-006702-ekf6mja9	1273	14	be	be	VB
cord-006702-ekf6mja9	1273	15	presented	present	VBN
cord-006702-ekf6mja9	1273	16	.	.	.
cord-006702-ekf6mja9	1274	1	The	the	DT
cord-006702-ekf6mja9	1274	2	results	result	NNS
cord-006702-ekf6mja9	1274	3	of	of	IN
cord-006702-ekf6mja9	1274	4	this	this	DT
cord-006702-ekf6mja9	1274	5	Phase	phase	NN
cord-006702-ekf6mja9	1274	6	1/2	1/2	CD
cord-006702-ekf6mja9	1274	7	trial	trial	NN
cord-006702-ekf6mja9	1274	8	of	of	IN
cord-006702-ekf6mja9	1274	9	ALN	ALN	NNP
cord-006702-ekf6mja9	1274	10	-	-	HYPH
cord-006702-ekf6mja9	1274	11	GO1	GO1	NNP
cord-006702-ekf6mja9	1274	12	will	will	MD
cord-006702-ekf6mja9	1274	13	guide	guide	VB
cord-006702-ekf6mja9	1274	14	future	future	JJ
cord-006702-ekf6mja9	1274	15	stages	stage	NNS
cord-006702-ekf6mja9	1274	16	of	of	IN
cord-006702-ekf6mja9	1274	17	development	development	NN
cord-006702-ekf6mja9	1274	18	of	of	IN
cord-006702-ekf6mja9	1274	19	ALN	ALN	NNP
cord-006702-ekf6mja9	1274	20	-	-	HYPH
cord-006702-ekf6mja9	1274	21	GO1	GO1	NNP
cord-006702-ekf6mja9	1274	22	in	in	IN
cord-006702-ekf6mja9	1274	23	patients	patient	NNS
cord-006702-ekf6mja9	1274	24	with	with	IN
cord-006702-ekf6mja9	1274	25	PH1	PH1	NNP
cord-006702-ekf6mja9	1274	26	.	.	.
cord-006702-ekf6mja9	1275	1	FP	FP	NNP
cord-006702-ekf6mja9	1275	2	-	-	HYPH
cord-006702-ekf6mja9	1275	3	S36	S36	NNP
cord-006702-ekf6mja9	1275	4	-	-	HYPH
cord-006702-ekf6mja9	1275	5	3	3	CD
cord-006702-ekf6mja9	1276	1	Do	do	VBP
cord-006702-ekf6mja9	1276	2	patients	patient	NNS
cord-006702-ekf6mja9	1276	3	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	1276	4	with	with	IN
cord-006702-ekf6mja9	1276	5	primary	primary	JJ
cord-006702-ekf6mja9	1276	6	hyperoxaluria	hyperoxaluria	NNP
cord-006702-ekf6mja9	1276	7	through	through	IN
cord-006702-ekf6mja9	1276	8	family	family	NN
cord-006702-ekf6mja9	1276	9	screening	screening	NN
cord-006702-ekf6mja9	1276	10	have	have	VBP
cord-006702-ekf6mja9	1276	11	different	different	JJ
cord-006702-ekf6mja9	1276	12	characteristics	characteristic	NNS
cord-006702-ekf6mja9	1276	13	compared	compare	VBN
cord-006702-ekf6mja9	1276	14	with	with	IN
cord-006702-ekf6mja9	1276	15	those	those	DT
cord-006702-ekf6mja9	1276	16	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	1276	17	conventionally	conventionally	RB
cord-006702-ekf6mja9	1276	18	?	?	.
cord-006702-ekf6mja9	1277	1	D.J.	D.J.	NNP
cord-006702-ekf6mja9	1277	2	Sas	Sas	NNP
cord-006702-ekf6mja9	1277	3	(	(	-LRB-
cord-006702-ekf6mja9	1277	4	1	1	CD
cord-006702-ekf6mja9	1277	5	)	)	-RRB-
cord-006702-ekf6mja9	1277	6	,	,	,
cord-006702-ekf6mja9	1277	7	F.T.	F.T.	NNP
cord-006702-ekf6mja9	1277	8	Enders	Enders	NNP
cord-006702-ekf6mja9	1277	9	(	(	-LRB-
cord-006702-ekf6mja9	1277	10	1	1	CD
cord-006702-ekf6mja9	1277	11	)	)	-RRB-
cord-006702-ekf6mja9	1277	12	,	,	,
cord-006702-ekf6mja9	1277	13	R.A.	R.A.	NNP
cord-006702-ekf6mja9	1277	14	Mehta	Mehta	NNP
cord-006702-ekf6mja9	1277	15	(	(	-LRB-
cord-006702-ekf6mja9	1277	16	1	1	CD
cord-006702-ekf6mja9	1277	17	)	)	-RRB-
cord-006702-ekf6mja9	1277	18	,	,	,
cord-006702-ekf6mja9	1277	19	X.	X.	NNP
cord-006702-ekf6mja9	1277	20	Tang	Tang	NNP
cord-006702-ekf6mja9	1277	21	(	(	-LRB-
cord-006702-ekf6mja9	1277	22	2	2	CD
cord-006702-ekf6mja9	1277	23	)	)	-RRB-
cord-006702-ekf6mja9	1277	24	,	,	,
cord-006702-ekf6mja9	1277	25	F.	F.	NNP
cord-006702-ekf6mja9	1277	26	Zhao	Zhao	NNP
cord-006702-ekf6mja9	1277	27	(	(	-LRB-
cord-006702-ekf6mja9	1277	28	1	1	CD
cord-006702-ekf6mja9	1277	29	)	)	-RRB-
cord-006702-ekf6mja9	1277	30	,	,	,
cord-006702-ekf6mja9	1277	31	B.M.	B.M.	NNP
cord-006702-ekf6mja9	1277	32	Seide	Seide	NNP
cord-006702-ekf6mja9	1277	33	(	(	-LRB-
cord-006702-ekf6mja9	1277	34	1	1	CD
cord-006702-ekf6mja9	1277	35	)	)	-RRB-
cord-006702-ekf6mja9	1277	36	,	,	,
cord-006702-ekf6mja9	1277	37	D.S.	D.S.	NNP
cord-006702-ekf6mja9	1277	38	Milliner	Milliner	NNP
cord-006702-ekf6mja9	1277	39	(	(	-LRB-
cord-006702-ekf6mja9	1277	40	1	1	CD
cord-006702-ekf6mja9	1277	41	)	)	-RRB-
cord-006702-ekf6mja9	1277	42	,	,	.
cord-006702-ekf6mja9	1278	1	J.C.	J.C.	NNP
cord-006702-ekf6mja9	1278	2	Lieske	Lieske	NNP
cord-006702-ekf6mja9	1278	3	(	(	-LRB-
cord-006702-ekf6mja9	1278	4	1	1	CD
cord-006702-ekf6mja9	1278	5	)	)	-RRB-
cord-006702-ekf6mja9	1278	6	(	(	-LRB-
cord-006702-ekf6mja9	1278	7	1	1	CD
cord-006702-ekf6mja9	1278	8	)	)	-RRB-
cord-006702-ekf6mja9	1278	9	Mayo	Mayo	NNP
cord-006702-ekf6mja9	1278	10	Clinic	Clinic	NNP
cord-006702-ekf6mja9	1278	11	,	,	,
cord-006702-ekf6mja9	1278	12	Rochester	Rochester	NNP
cord-006702-ekf6mja9	1278	13	,	,	,
cord-006702-ekf6mja9	1278	14	United	United	NNP
cord-006702-ekf6mja9	1278	15	States	States	NNP
cord-006702-ekf6mja9	1278	16	;	;	:
cord-006702-ekf6mja9	1278	17	(	(	-LRB-
cord-006702-ekf6mja9	1278	18	2	2	LS
cord-006702-ekf6mja9	1278	19	)	)	-RRB-
cord-006702-ekf6mja9	1279	1	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	1279	2	Changzheng	Changzheng	NNP
cord-006702-ekf6mja9	1279	3	Hospital	Hospital	NNP
cord-006702-ekf6mja9	1279	4	,	,	,
cord-006702-ekf6mja9	1279	5	Second	Second	NNP
cord-006702-ekf6mja9	1279	6	Military	Military	NNP
cord-006702-ekf6mja9	1279	7	Medical	Medical	NNP
cord-006702-ekf6mja9	1279	8	University	University	NNP
cord-006702-ekf6mja9	1279	9	,	,	,
cord-006702-ekf6mja9	1279	10	Shanghai	Shanghai	NNP
cord-006702-ekf6mja9	1279	11	,	,	,
cord-006702-ekf6mja9	1280	1	China	China	NNP
cord-006702-ekf6mja9	1280	2	Objectives	Objectives	NNPS
cord-006702-ekf6mja9	1280	3	:	:	:
cord-006702-ekf6mja9	1280	4	Primary	primary	JJ
cord-006702-ekf6mja9	1280	5	hyperoxaluria	hyperoxaluria	NN
cord-006702-ekf6mja9	1280	6	(	(	-LRB-
cord-006702-ekf6mja9	1280	7	PH	PH	NNP
cord-006702-ekf6mja9	1280	8	)	)	-RRB-
cord-006702-ekf6mja9	1280	9	is	be	VBZ
cord-006702-ekf6mja9	1280	10	an	an	DT
cord-006702-ekf6mja9	1280	11	inherited	inherit	VBN
cord-006702-ekf6mja9	1280	12	disease	disease	NN
cord-006702-ekf6mja9	1280	13	characterized	characterize	VBN
cord-006702-ekf6mja9	1280	14	by	by	IN
cord-006702-ekf6mja9	1280	15	excessive	excessive	JJ
cord-006702-ekf6mja9	1280	16	production	production	NN
cord-006702-ekf6mja9	1280	17	of	of	IN
cord-006702-ekf6mja9	1280	18	oxalate	oxalate	NN
cord-006702-ekf6mja9	1280	19	leading	lead	VBG
cord-006702-ekf6mja9	1280	20	to	to	IN
cord-006702-ekf6mja9	1280	21	recurrent	recurrent	JJ
cord-006702-ekf6mja9	1280	22	nephrolithiasis	nephrolithiasis	NN
cord-006702-ekf6mja9	1280	23	,	,	,
cord-006702-ekf6mja9	1280	24	nephrocalcinosis	nephrocalcinosis	NN
cord-006702-ekf6mja9	1280	25	and	and	CC
cord-006702-ekf6mja9	1280	26	progressive	progressive	JJ
cord-006702-ekf6mja9	1280	27	kidney	kidney	NN
cord-006702-ekf6mja9	1280	28	damage	damage	NN
cord-006702-ekf6mja9	1280	29	.	.	.
cord-006702-ekf6mja9	1281	1	Most	Most	JJS
cord-006702-ekf6mja9	1281	2	PH	PH	NNP
cord-006702-ekf6mja9	1281	3	patients	patient	NNS
cord-006702-ekf6mja9	1281	4	are	be	VBP
cord-006702-ekf6mja9	1281	5	diagnosed	diagnose	VBN
cord-006702-ekf6mja9	1281	6	through	through	IN
cord-006702-ekf6mja9	1281	7	evaluation	evaluation	NN
cord-006702-ekf6mja9	1281	8	initiated	initiate	VBN
cord-006702-ekf6mja9	1281	9	for	for	IN
cord-006702-ekf6mja9	1281	10	clinical	clinical	JJ
cord-006702-ekf6mja9	1281	11	suspicion	suspicion	NN
cord-006702-ekf6mja9	1281	12	(	(	-LRB-
cord-006702-ekf6mja9	1281	13	CS	CS	NNP
cord-006702-ekf6mja9	1281	14	)	)	-RRB-
cord-006702-ekf6mja9	1281	15	based	base	VBN
cord-006702-ekf6mja9	1281	16	on	on	IN
cord-006702-ekf6mja9	1281	17	signs	sign	NNS
cord-006702-ekf6mja9	1281	18	or	or	CC
cord-006702-ekf6mja9	1281	19	symptoms	symptom	NNS
cord-006702-ekf6mja9	1281	20	.	.	.
cord-006702-ekf6mja9	1282	1	However	however	RB
cord-006702-ekf6mja9	1282	2	,	,	,
cord-006702-ekf6mja9	1282	3	some	some	DT
cord-006702-ekf6mja9	1282	4	are	be	VBP
cord-006702-ekf6mja9	1282	5	detected	detect	VBN
cord-006702-ekf6mja9	1282	6	by	by	IN
cord-006702-ekf6mja9	1282	7	family	family	NN
cord-006702-ekf6mja9	1282	8	screening	screening	NN
cord-006702-ekf6mja9	1282	9	(	(	-LRB-
cord-006702-ekf6mja9	1282	10	FS	FS	NNP
cord-006702-ekf6mja9	1282	11	)	)	-RRB-
cord-006702-ekf6mja9	1282	12	once	once	IN
cord-006702-ekf6mja9	1282	13	an	an	DT
cord-006702-ekf6mja9	1282	14	affected	affected	JJ
cord-006702-ekf6mja9	1282	15	family	family	NN
cord-006702-ekf6mja9	1282	16	member	member	NN
cord-006702-ekf6mja9	1282	17	has	have	VBZ
cord-006702-ekf6mja9	1282	18	been	be	VBN
cord-006702-ekf6mja9	1282	19	identified	identify	VBN
cord-006702-ekf6mja9	1282	20	.	.	.
cord-006702-ekf6mja9	1283	1	We	-PRON-	PRP
cord-006702-ekf6mja9	1283	2	sought	seek	VBD
cord-006702-ekf6mja9	1283	3	to	to	TO
cord-006702-ekf6mja9	1283	4	characterize	characterize	VB
cord-006702-ekf6mja9	1283	5	differences	difference	NNS
cord-006702-ekf6mja9	1283	6	between	between	IN
cord-006702-ekf6mja9	1283	7	these	these	DT
cord-006702-ekf6mja9	1283	8	two	two	CD
cord-006702-ekf6mja9	1283	9	groups	group	NNS
cord-006702-ekf6mja9	1283	10	.	.	.
cord-006702-ekf6mja9	1283	11	 	 	_SP
cord-006702-ekf6mja9	1284	1	L.	L.	NNP
cord-006702-ekf6mja9	1284	2	Greenbaum	Greenbaum	NNP
cord-006702-ekf6mja9	1284	3	(	(	-LRB-
cord-006702-ekf6mja9	1284	4	3	3	CD
cord-006702-ekf6mja9	1284	5	)	)	-RRB-
cord-006702-ekf6mja9	1284	6	,	,	,
cord-006702-ekf6mja9	1284	7	G.	G.	NNP
cord-006702-ekf6mja9	1284	8	Ariceta	Ariceta	NNP
cord-006702-ekf6mja9	1284	9	United	United	NNP
cord-006702-ekf6mja9	1284	10	States	States	NNP
cord-006702-ekf6mja9	1284	11	;	;	:
cord-006702-ekf6mja9	1284	12	(	(	-LRB-
cord-006702-ekf6mja9	1284	13	3	3	LS
cord-006702-ekf6mja9	1284	14	)	)	-RRB-
cord-006702-ekf6mja9	1284	15	Emory	Emory	NNP
cord-006702-ekf6mja9	1284	16	School	School	NNP
cord-006702-ekf6mja9	1284	17	of	of	IN
cord-006702-ekf6mja9	1284	18	Medicine	Medicine	NNP
cord-006702-ekf6mja9	1284	19	and	and	CC
cord-006702-ekf6mja9	1284	20	Children	Children	NNP
cord-006702-ekf6mja9	1284	21	's	's	POS
cord-006702-ekf6mja9	1284	22	Healthcare	Healthcare	NNP
cord-006702-ekf6mja9	1284	23	of	of	IN
cord-006702-ekf6mja9	1284	24	Atlanta	Atlanta	NNP
cord-006702-ekf6mja9	1284	25	Calcitriol	Calcitriol	NNP
cord-006702-ekf6mja9	1284	26	treatment	treatment	NN
cord-006702-ekf6mja9	1284	27	ameliorates	ameliorate	VBZ
cord-006702-ekf6mja9	1284	28	FGF23	FGF23	NNP
cord-006702-ekf6mja9	1284	29	/	/	SYM
cord-006702-ekf6mja9	1284	30	FGFR4-induced	FGFR4-induced	NNP
cord-006702-ekf6mja9	1284	31	cardiac	cardiac	NN
cord-006702-ekf6mja9	1284	32	myocyte	myocyte	NN
cord-006702-ekf6mja9	1284	33	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	1284	34	in	in	IN
cord-006702-ekf6mja9	1284	35	vitro	vitro	FW
cord-006702-ekf6mja9	1284	36	and	and	CC
cord-006702-ekf6mja9	1284	37	in	in	IN
cord-006702-ekf6mja9	1284	38	vivo	vivo	NNP
cord-006702-ekf6mja9	1284	39	M.	M.	NNP
cord-006702-ekf6mja9	1284	40	Leifheit	Leifheit	NNP
cord-006702-ekf6mja9	1284	41	-	-	HYPH
cord-006702-ekf6mja9	1284	42	Nestler	Nestler	NNP
cord-006702-ekf6mja9	1284	43	(	(	-LRB-
cord-006702-ekf6mja9	1284	44	1	1	CD
cord-006702-ekf6mja9	1284	45	)	)	-RRB-
cord-006702-ekf6mja9	1284	46	Vitamin	vitamin	NN
cord-006702-ekf6mja9	1284	47	D	d	NN
cord-006702-ekf6mja9	1284	48	deficiency	deficiency	NN
cord-006702-ekf6mja9	1284	49	and	and	CC
cord-006702-ekf6mja9	1284	50	excess	excess	NN
cord-006702-ekf6mja9	1284	51	of	of	IN
cord-006702-ekf6mja9	1284	52	FGF23	fgf23	NN
cord-006702-ekf6mja9	1284	53	are	be	VBP
cord-006702-ekf6mja9	1284	54	contributors	contributor	NNS
cord-006702-ekf6mja9	1284	55	to	to	IN
cord-006702-ekf6mja9	1284	56	cardiovascular	cardiovascular	JJ
cord-006702-ekf6mja9	1284	57	mortality	mortality	NN
cord-006702-ekf6mja9	1284	58	in	in	IN
cord-006702-ekf6mja9	1284	59	CKD	CKD	NNP
cord-006702-ekf6mja9	1284	60	patients	patient	NNS
cord-006702-ekf6mja9	1284	61	.	.	.
cord-006702-ekf6mja9	1285	1	FGF23	fgf23	NN
cord-006702-ekf6mja9	1285	2	exclusively	exclusively	RB
cord-006702-ekf6mja9	1285	3	activates	activate	VBZ
cord-006702-ekf6mja9	1285	4	FGF	FGF	NNP
cord-006702-ekf6mja9	1285	5	receptor	receptor	NN
cord-006702-ekf6mja9	1285	6	(	(	-LRB-
cord-006702-ekf6mja9	1285	7	FGFR	FGFR	NNP
cord-006702-ekf6mja9	1285	8	)	)	-RRB-
cord-006702-ekf6mja9	1285	9	4	4	CD
cord-006702-ekf6mja9	1285	10	to	to	TO
cord-006702-ekf6mja9	1285	11	stimulate	stimulate	VB
cord-006702-ekf6mja9	1285	12	LVH	LVH	NNP
cord-006702-ekf6mja9	1285	13	,	,	,
cord-006702-ekf6mja9	1285	14	and	and	CC
cord-006702-ekf6mja9	1285	15	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1285	16	expression	expression	NN
cord-006702-ekf6mja9	1285	17	of	of	IN
cord-006702-ekf6mja9	1285	18	FGF23	FGF23	NNP
cord-006702-ekf6mja9	1285	19	correlates	correlate	VBZ
cord-006702-ekf6mja9	1285	20	with	with	IN
cord-006702-ekf6mja9	1285	21	the	the	DT
cord-006702-ekf6mja9	1285	22	presence	presence	NN
cord-006702-ekf6mja9	1285	23	of	of	IN
cord-006702-ekf6mja9	1285	24	LVH	LVH	NNP
cord-006702-ekf6mja9	1285	25	in	in	IN
cord-006702-ekf6mja9	1285	26	CKD	CKD	NNP
cord-006702-ekf6mja9	1285	27	.	.	.
cord-006702-ekf6mja9	1286	1	1,25-dihydroxyvitamin	1,25-dihydroxyvitamin	LS
cord-006702-ekf6mja9	1286	2	D	D	NNP
cord-006702-ekf6mja9	1286	3	(	(	-LRB-
cord-006702-ekf6mja9	1286	4	1,25D	1,25d	CD
cord-006702-ekf6mja9	1286	5	)	)	-RRB-
cord-006702-ekf6mja9	1286	6	is	be	VBZ
cord-006702-ekf6mja9	1286	7	known	know	VBN
cord-006702-ekf6mja9	1286	8	to	to	TO
cord-006702-ekf6mja9	1286	9	have	have	VB
cord-006702-ekf6mja9	1286	10	cardioprotective	cardioprotective	JJ
cord-006702-ekf6mja9	1286	11	properties	property	NNS
cord-006702-ekf6mja9	1286	12	,	,	,
cord-006702-ekf6mja9	1286	13	but	but	CC
cord-006702-ekf6mja9	1286	14	may	may	MD
cord-006702-ekf6mja9	1286	15	further	further	RB
cord-006702-ekf6mja9	1286	16	stimulate	stimulate	VB
cord-006702-ekf6mja9	1286	17	FGF23	fgf23	NN
cord-006702-ekf6mja9	1286	18	synthesis	synthesis	NN
cord-006702-ekf6mja9	1286	19	and	and	CC
cord-006702-ekf6mja9	1286	20	thus	thus	RB
cord-006702-ekf6mja9	1286	21	LVH	LVH	NNP
cord-006702-ekf6mja9	1286	22	in	in	IN
cord-006702-ekf6mja9	1286	23	CKD	CKD	NNP
cord-006702-ekf6mja9	1286	24	.	.	.
cord-006702-ekf6mja9	1287	1	Here	here	RB
cord-006702-ekf6mja9	1287	2	,	,	,
cord-006702-ekf6mja9	1287	3	we	-PRON-	PRP
cord-006702-ekf6mja9	1287	4	investigated	investigate	VBD
cord-006702-ekf6mja9	1287	5	the	the	DT
cord-006702-ekf6mja9	1287	6	dose	dose	NN
cord-006702-ekf6mja9	1287	7	-	-	HYPH
cord-006702-ekf6mja9	1287	8	and	and	CC
cord-006702-ekf6mja9	1287	9	timedependent	timedependent	NN
cord-006702-ekf6mja9	1287	10	effects	effect	NNS
cord-006702-ekf6mja9	1287	11	of	of	IN
cord-006702-ekf6mja9	1287	12	calcitriol	calcitriol	NN
cord-006702-ekf6mja9	1287	13	treatment	treatment	NN
cord-006702-ekf6mja9	1287	14	on	on	IN
cord-006702-ekf6mja9	1287	15	i	i	NNP
cord-006702-ekf6mja9	1287	16	)	)	-RRB-
cord-006702-ekf6mja9	1287	17	FGF23	fgf23	NN
cord-006702-ekf6mja9	1287	18	/	/	SYM
cord-006702-ekf6mja9	1287	19	FGFR4	fgfr4	NN
cord-006702-ekf6mja9	1287	20	system	system	NN
cord-006702-ekf6mja9	1287	21	and	and	CC
cord-006702-ekf6mja9	1287	22	LVH	LVH	NNP
cord-006702-ekf6mja9	1287	23	in	in	IN
cord-006702-ekf6mja9	1287	24	5/6	5/6	CD
cord-006702-ekf6mja9	1287	25	nephrectomized	nephrectomized	JJ
cord-006702-ekf6mja9	1287	26	rats	rat	NNS
cord-006702-ekf6mja9	1287	27	(	(	-LRB-
cord-006702-ekf6mja9	1287	28	Nx	Nx	NNP
cord-006702-ekf6mja9	1287	29	)	)	-RRB-
cord-006702-ekf6mja9	1287	30	,	,	,
cord-006702-ekf6mja9	1287	31	and	and	CC
cord-006702-ekf6mja9	1287	32	ii	ii	LS
cord-006702-ekf6mja9	1287	33	)	)	-RRB-
cord-006702-ekf6mja9	1288	1	FGF23-induced	FGF23-induced	NNP
cord-006702-ekf6mja9	1289	1	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	1289	2	of	of	IN
cord-006702-ekf6mja9	1289	3	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1289	4	myocytes	myocyte	NNS
cord-006702-ekf6mja9	1289	5	in	in	IN
cord-006702-ekf6mja9	1289	6	vitro	vitro	FW
cord-006702-ekf6mja9	1289	7	.	.	.
cord-006702-ekf6mja9	1290	1	Methods	method	NNS
cord-006702-ekf6mja9	1290	2	:	:	:
cord-006702-ekf6mja9	1290	3	5/6Nx	5/6nx	CD
cord-006702-ekf6mja9	1290	4	were	be	VBD
cord-006702-ekf6mja9	1290	5	treated	treat	VBN
cord-006702-ekf6mja9	1290	6	with	with	IN
cord-006702-ekf6mja9	1290	7	1,25D	1,25d	CD
cord-006702-ekf6mja9	1290	8	(	(	-LRB-
cord-006702-ekf6mja9	1290	9	0	0	CD
cord-006702-ekf6mja9	1290	10	-	-	SYM
cord-006702-ekf6mja9	1290	11	300	300	CD
cord-006702-ekf6mja9	1290	12	ng	ng	NN
cord-006702-ekf6mja9	1290	13	/	/	SYM
cord-006702-ekf6mja9	1290	14	kg	kg	NNP
cord-006702-ekf6mja9	1290	15	BW	BW	NNP
cord-006702-ekf6mja9	1290	16	/	/	SYM
cord-006702-ekf6mja9	1290	17	d	d	NN
cord-006702-ekf6mja9	1290	18	)	)	-RRB-
cord-006702-ekf6mja9	1290	19	for	for	IN
cord-006702-ekf6mja9	1290	20	4	4	CD
cord-006702-ekf6mja9	1290	21	and	and	CC
cord-006702-ekf6mja9	1290	22	10	10	CD
cord-006702-ekf6mja9	1290	23	weeks	week	NNS
cord-006702-ekf6mja9	1290	24	,	,	,
cord-006702-ekf6mja9	1290	25	respectively	respectively	RB
cord-006702-ekf6mja9	1290	26	.	.	.
cord-006702-ekf6mja9	1291	1	Hearts	heart	NNS
cord-006702-ekf6mja9	1291	2	were	be	VBD
cord-006702-ekf6mja9	1291	3	investigated	investigate	VBN
cord-006702-ekf6mja9	1291	4	for	for	IN
cord-006702-ekf6mja9	1291	5	FGF23	fgf23	NN
cord-006702-ekf6mja9	1291	6	signaling	signaling	NN
cord-006702-ekf6mja9	1291	7	,	,	,
cord-006702-ekf6mja9	1291	8	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1291	9	remodeling	remodeling	NN
cord-006702-ekf6mja9	1291	10	,	,	,
cord-006702-ekf6mja9	1291	11	and	and	CC
cord-006702-ekf6mja9	1291	12	LVH	LVH	NNP
cord-006702-ekf6mja9	1291	13	.	.	.
cord-006702-ekf6mja9	1292	1	Isolated	isolated	JJ
cord-006702-ekf6mja9	1292	2	neonatal	neonatal	JJ
cord-006702-ekf6mja9	1292	3	rat	rat	NN
cord-006702-ekf6mja9	1292	4	ventricular	ventricular	JJ
cord-006702-ekf6mja9	1292	5	myocytes	myocyte	NNS
cord-006702-ekf6mja9	1292	6	(	(	-LRB-
cord-006702-ekf6mja9	1292	7	NRVM	NRVM	NNP
cord-006702-ekf6mja9	1292	8	)	)	-RRB-
cord-006702-ekf6mja9	1292	9	were	be	VBD
cord-006702-ekf6mja9	1292	10	stimulated	stimulate	VBN
cord-006702-ekf6mja9	1292	11	with	with	IN
cord-006702-ekf6mja9	1292	12	1,25D	1,25d	CD
cord-006702-ekf6mja9	1292	13	and/or	and/or	CC
cord-006702-ekf6mja9	1292	14	FGF23	FGF23	NNP
cord-006702-ekf6mja9	1292	15	and	and	CC
cord-006702-ekf6mja9	1292	16	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1292	17	for	for	IN
cord-006702-ekf6mja9	1292	18	myocardial	myocardial	JJ
cord-006702-ekf6mja9	1292	19	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	1292	20	.	.	.
cord-006702-ekf6mja9	1293	1	Results	result	NNS
cord-006702-ekf6mja9	1293	2	:	:	:
cord-006702-ekf6mja9	1294	1	Vehicle	vehicle	NN
cord-006702-ekf6mja9	1294	2	-	-	HYPH
cord-006702-ekf6mja9	1294	3	treated	treat	VBN
cord-006702-ekf6mja9	1294	4	5/6Nx	5/6nx	CD
cord-006702-ekf6mja9	1294	5	rats	rat	NNS
cord-006702-ekf6mja9	1294	6	show	show	VBP
cord-006702-ekf6mja9	1294	7	enhanced	enhanced	JJ
cord-006702-ekf6mja9	1294	8	expression	expression	NN
cord-006702-ekf6mja9	1294	9	of	of	IN
cord-006702-ekf6mja9	1294	10	Fgf23	Fgf23	NNP
cord-006702-ekf6mja9	1294	11	in	in	IN
cord-006702-ekf6mja9	1294	12	bone	bone	NN
cord-006702-ekf6mja9	1294	13	and	and	CC
cord-006702-ekf6mja9	1294	14	myocardium	myocardium	NN
cord-006702-ekf6mja9	1294	15	Both	both	DT
cord-006702-ekf6mja9	1294	16	bone	bone	NN
cord-006702-ekf6mja9	1294	17	and	and	CC
cord-006702-ekf6mja9	1294	18	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1294	19	Fgf23	Fgf23	NNP
cord-006702-ekf6mja9	1294	20	gene	gene	NN
cord-006702-ekf6mja9	1294	21	expression	expression	NN
cord-006702-ekf6mja9	1294	22	,	,	,
cord-006702-ekf6mja9	1294	23	and	and	CC
cord-006702-ekf6mja9	1294	24	total	total	JJ
cord-006702-ekf6mja9	1294	25	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1294	26	Fgf23	Fgf23	NNP
cord-006702-ekf6mja9	1294	27	protein	protein	NN
cord-006702-ekf6mja9	1294	28	levels	level	NNS
cord-006702-ekf6mja9	1294	29	are	be	VBP
cord-006702-ekf6mja9	1294	30	further	further	RB
cord-006702-ekf6mja9	1294	31	stimulated	stimulate	VBN
cord-006702-ekf6mja9	1294	32	by	by	IN
cord-006702-ekf6mja9	1294	33	1,25D	1,25d	CD
cord-006702-ekf6mja9	1294	34	,	,	,
cord-006702-ekf6mja9	1294	35	whereas	whereas	IN
cord-006702-ekf6mja9	1294	36	full	full	JJ
cord-006702-ekf6mja9	1294	37	-	-	HYPH
cord-006702-ekf6mja9	1294	38	length	length	NN
cord-006702-ekf6mja9	1294	39	intact	intact	JJ
cord-006702-ekf6mja9	1294	40	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1294	41	Fgf23	Fgf23	NNP
cord-006702-ekf6mja9	1294	42	protein	protein	NN
cord-006702-ekf6mja9	1294	43	,	,	,
cord-006702-ekf6mja9	1294	44	Fgfr4	Fgfr4	NNS
cord-006702-ekf6mja9	1294	45	,	,	,
cord-006702-ekf6mja9	1294	46	and	and	CC
cord-006702-ekf6mja9	1294	47	calcineurin	calcineurin	NN
cord-006702-ekf6mja9	1294	48	-	-	:
cord-006702-ekf6mja9	1294	49	NFAT	NFAT	NNP
cord-006702-ekf6mja9	1294	50	signaling	signaling	NN
cord-006702-ekf6mja9	1294	51	are	be	VBP
cord-006702-ekf6mja9	1294	52	suppressed	suppress	VBN
cord-006702-ekf6mja9	1294	53	.	.	.
cord-006702-ekf6mja9	1295	1	Expression	expression	NN
cord-006702-ekf6mja9	1295	2	of	of	IN
cord-006702-ekf6mja9	1295	3	RCAN1	rcan1	NN
cord-006702-ekf6mja9	1295	4	,	,	,
cord-006702-ekf6mja9	1295	5	TRPC6	TRPC6	NNP
cord-006702-ekf6mja9	1295	6	,	,	,
cord-006702-ekf6mja9	1295	7	and	and	CC
cord-006702-ekf6mja9	1295	8	pro	pro	JJ
cord-006702-ekf6mja9	1295	9	-	-	JJ
cord-006702-ekf6mja9	1295	10	hypertrophic	hypertrophic	JJ
cord-006702-ekf6mja9	1295	11	genes	gene	NNS
cord-006702-ekf6mja9	1295	12	are	be	VBP
cord-006702-ekf6mja9	1295	13	increased	increase	VBN
cord-006702-ekf6mja9	1295	14	in	in	IN
cord-006702-ekf6mja9	1295	15	5/6Nx	5/6nx	CD
cord-006702-ekf6mja9	1295	16	rats	rat	NNS
cord-006702-ekf6mja9	1295	17	,	,	,
cord-006702-ekf6mja9	1295	18	and	and	CC
cord-006702-ekf6mja9	1295	19	downregulated	downregulate	VBN
cord-006702-ekf6mja9	1295	20	by	by	IN
cord-006702-ekf6mja9	1295	21	1,25D.	1,25d.	CD
cord-006702-ekf6mja9	1296	1	In	in	IN
cord-006702-ekf6mja9	1296	2	NRVM	NRVM	NNP
cord-006702-ekf6mja9	1296	3	,	,	,
cord-006702-ekf6mja9	1296	4	1,25D	1,25d	CD
cord-006702-ekf6mja9	1296	5	induces	induce	VBZ
cord-006702-ekf6mja9	1296	6	Fgf23	Fgf23	NNP
cord-006702-ekf6mja9	1296	7	and	and	CC
cord-006702-ekf6mja9	1296	8	Fgfr4	Fgfr4	NNP
cord-006702-ekf6mja9	1296	9	mRNA	mRNA	NNP
cord-006702-ekf6mja9	1296	10	levels	level	NNS
cord-006702-ekf6mja9	1296	11	,	,	,
cord-006702-ekf6mja9	1296	12	whereas	whereas	IN
cord-006702-ekf6mja9	1296	13	the	the	DT
cord-006702-ekf6mja9	1296	14	expression	expression	NN
cord-006702-ekf6mja9	1296	15	of	of	IN
cord-006702-ekf6mja9	1296	16	RCAN1	RCAN1	NNP
cord-006702-ekf6mja9	1296	17	and	and	CC
cord-006702-ekf6mja9	1296	18	BNP	BNP	NNP
cord-006702-ekf6mja9	1296	19	,	,	,
cord-006702-ekf6mja9	1296	20	and	and	CC
cord-006702-ekf6mja9	1296	21	the	the	DT
cord-006702-ekf6mja9	1296	22	size	size	NN
cord-006702-ekf6mja9	1296	23	of	of	IN
cord-006702-ekf6mja9	1296	24	cardiac	cardiac	JJ
cord-006702-ekf6mja9	1296	25	myocytes	myocyte	NNS
cord-006702-ekf6mja9	1296	26	remain	remain	VBP
cord-006702-ekf6mja9	1296	27	unaffected	unaffected	JJ
cord-006702-ekf6mja9	1296	28	.	.	.
cord-006702-ekf6mja9	1297	1	1,25D	1,25d	CD
cord-006702-ekf6mja9	1297	2	treatment	treatment	NN
cord-006702-ekf6mja9	1297	3	blunted	blunt	VBD
cord-006702-ekf6mja9	1297	4	FGF23-induced	fgf23-induced	CD
cord-006702-ekf6mja9	1297	5	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	1297	6	in	in	IN
cord-006702-ekf6mja9	1297	7	NRVM	NRVM	NNP
cord-006702-ekf6mja9	1297	8	.	.	.
cord-006702-ekf6mja9	1298	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1298	2	:	:	:
cord-006702-ekf6mja9	1299	1	1,25D	1,25d	CD
cord-006702-ekf6mja9	1299	2	ameliorates	ameliorate	VBZ
cord-006702-ekf6mja9	1299	3	LVH	LVH	NNP
cord-006702-ekf6mja9	1299	4	in	in	IN
cord-006702-ekf6mja9	1299	5	5/6Nx	5/6nx	CD
cord-006702-ekf6mja9	1299	6	rats	rat	NNS
cord-006702-ekf6mja9	1299	7	and	and	CC
cord-006702-ekf6mja9	1299	8	rescues	rescue	VBZ
cord-006702-ekf6mja9	1299	9	FGF23-induced	FGF23-induced	NNP
cord-006702-ekf6mja9	1299	10	cardiac	cardiac	NN
cord-006702-ekf6mja9	1299	11	myocyte	myocyte	NN
cord-006702-ekf6mja9	1299	12	hypertrophy	hypertrophy	NN
cord-006702-ekf6mja9	1299	13	in	in	IN
cord-006702-ekf6mja9	1299	14	vitro	vitro	FW
cord-006702-ekf6mja9	1299	15	S32	s32	NN
cord-006702-ekf6mja9	1299	16	-Vesicoureteric	-Vesicoureteric	.
cord-006702-ekf6mja9	1300	1	reflux	reflux	NN
cord-006702-ekf6mja9	1300	2	:	:	:
cord-006702-ekf6mja9	1301	1	What	what	WP
cord-006702-ekf6mja9	1301	2	's	be	VBZ
cord-006702-ekf6mja9	1301	3	new	new	JJ
cord-006702-ekf6mja9	1301	4	?	?	.
cord-006702-ekf6mja9	1302	1	FP	FP	NNP
cord-006702-ekf6mja9	1302	2	-	-	HYPH
cord-006702-ekf6mja9	1302	3	S32	S32	NNP
cord-006702-ekf6mja9	1302	4	-	-	HYPH
cord-006702-ekf6mja9	1302	5	1	1	CD
cord-006702-ekf6mja9	1303	1	Whole	whole	JJ
cord-006702-ekf6mja9	1303	2	exon	exon	NN
cord-006702-ekf6mja9	1303	3	sequencing	sequencing	NN
cord-006702-ekf6mja9	1303	4	(	(	-LRB-
cord-006702-ekf6mja9	1303	5	WES	WES	NNP
cord-006702-ekf6mja9	1303	6	)	)	-RRB-
cord-006702-ekf6mja9	1303	7	reveals	reveal	VBZ
cord-006702-ekf6mja9	1303	8	recurred	recur	VBN
cord-006702-ekf6mja9	1303	9	germ	germ	NN
cord-006702-ekf6mja9	1303	10	line	line	NN
cord-006702-ekf6mja9	1303	11	mutations	mutation	NNS
cord-006702-ekf6mja9	1303	12	in	in	IN
cord-006702-ekf6mja9	1303	13	Vesicoureteral	Vesicoureteral	NNP
cord-006702-ekf6mja9	1303	14	reflux	reflux	NN
cord-006702-ekf6mja9	1303	15	China	China	NNP
cord-006702-ekf6mja9	1303	16	&	&	CC
cord-006702-ekf6mja9	1303	17	Table	Table	NNP
cord-006702-ekf6mja9	1303	18	1	1	CD
cord-006702-ekf6mja9	1304	1	:	:	:
cord-006702-ekf6mja9	1304	2	list	list	NN
cord-006702-ekf6mja9	1304	3	of	of	IN
cord-006702-ekf6mja9	1304	4	possible	possible	JJ
cord-006702-ekf6mja9	1304	5	candidate	candidate	NN
cord-006702-ekf6mja9	1304	6	genes	gene	NNS
cord-006702-ekf6mja9	1304	7	Results	result	NNS
cord-006702-ekf6mja9	1304	8	:	:	:
cord-006702-ekf6mja9	1305	1	Median	median	JJ
cord-006702-ekf6mja9	1305	2	depth	depth	NN
cord-006702-ekf6mja9	1305	3	of	of	IN
cord-006702-ekf6mja9	1305	4	coverage	coverage	NN
cord-006702-ekf6mja9	1305	5	was	be	VBD
cord-006702-ekf6mja9	1305	6	48X	48x	CD
cord-006702-ekf6mja9	1305	7	&	&	CC
cord-006702-ekf6mja9	1305	8	target	target	NN
cord-006702-ekf6mja9	1305	9	coverage	coverage	NN
cord-006702-ekf6mja9	1305	10	94	94	CD
cord-006702-ekf6mja9	1305	11	%	%	NN
cord-006702-ekf6mja9	1305	12	at	at	IN
cord-006702-ekf6mja9	1305	13	10X.	10x.	CD
cord-006702-ekf6mja9	1305	14	Mutations	Mutations	NNPS
cord-006702-ekf6mja9	1305	15	&	&	CC
cord-006702-ekf6mja9	1305	16	CNVs	CNVs	NNPS
cord-006702-ekf6mja9	1305	17	in	in	IN
cord-006702-ekf6mja9	1305	18	essential	essential	JJ
cord-006702-ekf6mja9	1305	19	gene	gene	NN
cord-006702-ekf6mja9	1305	20	-	-	HYPH
cord-006702-ekf6mja9	1305	21	sets	set	NNS
cord-006702-ekf6mja9	1305	22	are	be	VBP
cord-006702-ekf6mja9	1305	23	shown	show	VBN
cord-006702-ekf6mja9	1305	24	No	no	DT
cord-006702-ekf6mja9	1305	25	mutation	mutation	NN
cord-006702-ekf6mja9	1305	26	was	be	VBD
cord-006702-ekf6mja9	1305	27	shared	share	VBN
cord-006702-ekf6mja9	1305	28	.	.	.
cord-006702-ekf6mja9	1306	1	1	1	CD
cord-006702-ekf6mja9	1306	2	mutation	mutation	NN
cord-006702-ekf6mja9	1306	3	was	be	VBD
cord-006702-ekf6mja9	1306	4	noted	note	VBN
cord-006702-ekf6mja9	1306	5	in	in	IN
cord-006702-ekf6mja9	1306	6	TMEM67	TMEM67	NNP
cord-006702-ekf6mja9	1306	7	,	,	,
cord-006702-ekf6mja9	1306	8	a	a	DT
cord-006702-ekf6mja9	1306	9	possible	possible	JJ
cord-006702-ekf6mja9	1306	10	candidate	candidate	NN
cord-006702-ekf6mja9	1306	11	gene	gene	NN
cord-006702-ekf6mja9	1306	12	that	that	WDT
cord-006702-ekf6mja9	1306	13	is	be	VBZ
cord-006702-ekf6mja9	1306	14	also	also	RB
cord-006702-ekf6mja9	1306	15	in	in	IN
cord-006702-ekf6mja9	1306	16	a	a	DT
cord-006702-ekf6mja9	1306	17	candidate	candidate	NN
cord-006702-ekf6mja9	1306	18	cytoband	cytoband	NNP
cord-006702-ekf6mja9	1306	19	&	&	CC
cord-006702-ekf6mja9	1306	20	0/2	0/2	CD
cord-006702-ekf6mja9	1306	21	patients	patient	NNS
cord-006702-ekf6mja9	1306	22	with	with	IN
cord-006702-ekf6mja9	1306	23	recurrent	recurrent	JJ
cord-006702-ekf6mja9	1306	24	UTI	UTI	NNP
cord-006702-ekf6mja9	1306	25	,	,	,
cord-006702-ekf6mja9	1306	26	worsening	worsen	VBG
cord-006702-ekf6mja9	1306	27	renal	renal	JJ
cord-006702-ekf6mja9	1306	28	scarring	scarring	NN
cord-006702-ekf6mja9	1306	29	,	,	,
cord-006702-ekf6mja9	1306	30	hypertension	hypertension	NN
cord-006702-ekf6mja9	1306	31	,	,	,
cord-006702-ekf6mja9	1306	32	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1306	33	&	&	CC
cord-006702-ekf6mja9	1306	34	voiding	void	VBG
cord-006702-ekf6mja9	1306	35	disorders	disorder	NNS
cord-006702-ekf6mja9	1306	36	,	,	,
cord-006702-ekf6mja9	1306	37	respectively	respectively	RB
cord-006702-ekf6mja9	1306	38	.	.	.
cord-006702-ekf6mja9	1307	1	XL	XL	NNP
cord-006702-ekf6mja9	1307	2	model	model	NN
cord-006702-ekf6mja9	1307	3	identified	identify	VBD
cord-006702-ekf6mja9	1307	4	6	6	CD
cord-006702-ekf6mja9	1307	5	variants	variant	NNS
cord-006702-ekf6mja9	1307	6	in	in	IN
cord-006702-ekf6mja9	1307	7	ARSD	ARSD	NNP
cord-006702-ekf6mja9	1307	8	,	,	,
cord-006702-ekf6mja9	1307	9	located	locate	VBN
cord-006702-ekf6mja9	1307	10	within	within	IN
cord-006702-ekf6mja9	1307	11	a	a	DT
cord-006702-ekf6mja9	1307	12	187	187	CD
cord-006702-ekf6mja9	1307	13	bp	bp	NNP
cord-006702-ekf6mja9	1307	14	intronic	intronic	NNP
cord-006702-ekf6mja9	1307	15	region	region	NN
cord-006702-ekf6mja9	1307	16	;	;	:
cord-006702-ekf6mja9	1307	17	3	3	CD
cord-006702-ekf6mja9	1307	18	-	-	SYM
cord-006702-ekf6mja9	1307	19	6	6	CD
cord-006702-ekf6mja9	1307	20	of	of	IN
cord-006702-ekf6mja9	1307	21	these	these	DT
cord-006702-ekf6mja9	1307	22	were	be	VBD
cord-006702-ekf6mja9	1307	23	seen	see	VBN
cord-006702-ekf6mja9	1307	24	in	in	IN
cord-006702-ekf6mja9	1307	25	all	all	DT
cord-006702-ekf6mja9	1307	26	9	9	CD
cord-006702-ekf6mja9	1307	27	boys	boy	NNS
cord-006702-ekf6mja9	1307	28	but	but	CC
cord-006702-ekf6mja9	1307	29	not	not	RB
cord-006702-ekf6mja9	1307	30	the	the	DT
cord-006702-ekf6mja9	1307	31	girl	girl	NN
cord-006702-ekf6mja9	1307	32	.	.	.
cord-006702-ekf6mja9	1308	1	AD	ad	NN
cord-006702-ekf6mja9	1308	2	model	model	NN
cord-006702-ekf6mja9	1308	3	identified	identify	VBD
cord-006702-ekf6mja9	1308	4	2	2	CD
cord-006702-ekf6mja9	1308	5	mutations	mutation	NNS
cord-006702-ekf6mja9	1308	6	in	in	IN
cord-006702-ekf6mja9	1308	7	AGA	AGA	NNP
cord-006702-ekf6mja9	1308	8	and	and	CC
cord-006702-ekf6mja9	1308	9	SLIT1	SLIT1	NNP
cord-006702-ekf6mja9	1308	10	&	&	CC
cord-006702-ekf6mja9	1308	11	Table	Table	NNP
cord-006702-ekf6mja9	1308	12	2	2	CD
cord-006702-ekf6mja9	1308	13	:	:	:
cord-006702-ekf6mja9	1308	14	variations	variation	NNS
cord-006702-ekf6mja9	1308	15	in	in	IN
cord-006702-ekf6mja9	1308	16	essential	essential	JJ
cord-006702-ekf6mja9	1308	17	gene	gene	NN
cord-006702-ekf6mja9	1308	18	-	-	HYPH
cord-006702-ekf6mja9	1308	19	sets	set	NNS
cord-006702-ekf6mja9	1308	20	and	and	CC
cord-006702-ekf6mja9	1308	21	CNVs	cnv	NNS
cord-006702-ekf6mja9	1308	22	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1308	23	:	:	:
cord-006702-ekf6mja9	1308	24	Exome	Exome	NNP
cord-006702-ekf6mja9	1308	25	sequencing	sequencing	NN
cord-006702-ekf6mja9	1308	26	using	use	VBG
cord-006702-ekf6mja9	1308	27	sharp	sharp	JJ
cord-006702-ekf6mja9	1308	28	phenotyping	phenotyping	NN
cord-006702-ekf6mja9	1308	29	is	be	VBZ
cord-006702-ekf6mja9	1308	30	a	a	DT
cord-006702-ekf6mja9	1308	31	promising	promising	JJ
cord-006702-ekf6mja9	1308	32	method	method	NN
cord-006702-ekf6mja9	1308	33	for	for	IN
cord-006702-ekf6mja9	1308	34	genetic	genetic	JJ
cord-006702-ekf6mja9	1308	35	discovery	discovery	NN
cord-006702-ekf6mja9	1308	36	in	in	IN
cord-006702-ekf6mja9	1308	37	VUR	VUR	NNP
cord-006702-ekf6mja9	1308	38	.	.	.
cord-006702-ekf6mja9	1309	1	TMEM67	TMEM67	NNP
cord-006702-ekf6mja9	1309	2	,	,	,
cord-006702-ekf6mja9	1309	3	AGA	AGA	NNP
cord-006702-ekf6mja9	1309	4	,	,	,
cord-006702-ekf6mja9	1309	5	SLIT	SLIT	NNP
cord-006702-ekf6mja9	1309	6	1	1	CD
cord-006702-ekf6mja9	1309	7	&	&	CC
cord-006702-ekf6mja9	1309	8	ARSD	ARSD	NNP
cord-006702-ekf6mja9	1309	9	are	be	VBP
cord-006702-ekf6mja9	1309	10	candidate	candidate	NN
cord-006702-ekf6mja9	1309	11	genes	gene	NNS
cord-006702-ekf6mja9	1309	12	.	.	.
cord-006702-ekf6mja9	1310	1	S33	S33	NNP
cord-006702-ekf6mja9	1310	2	-Infections	-Infections	.
cord-006702-ekf6mja9	1311	1	and	and	CC
cord-006702-ekf6mja9	1311	2	the	the	DT
cord-006702-ekf6mja9	1311	3	kidney	kidney	NN
cord-006702-ekf6mja9	1311	4	FP	FP	NNP
cord-006702-ekf6mja9	1311	5	-	-	HYPH
cord-006702-ekf6mja9	1311	6	S33	S33	NNP
cord-006702-ekf6mja9	1311	7	-	-	HYPH
cord-006702-ekf6mja9	1311	8	1	1	CD
cord-006702-ekf6mja9	1311	9	Examination	examination	NN
cord-006702-ekf6mja9	1311	10	of	of	IN
cord-006702-ekf6mja9	1311	11	clinical	clinical	JJ
cord-006702-ekf6mja9	1311	12	relationship	relationship	NN
cord-006702-ekf6mja9	1311	13	between	between	IN
cord-006702-ekf6mja9	1311	14	influenza	influenza	NN
cord-006702-ekf6mja9	1311	15	virus	virus	NN
cord-006702-ekf6mja9	1311	16	vaccine	vaccine	NN
cord-006702-ekf6mja9	1311	17	and	and	CC
cord-006702-ekf6mja9	1311	18	relapse	relapse	NN
cord-006702-ekf6mja9	1311	19	of	of	IN
cord-006702-ekf6mja9	1311	20	nephrotic	nephrotic	JJ
cord-006702-ekf6mja9	1311	21	syndrome	syndrome	NN
cord-006702-ekf6mja9	1311	22	in	in	IN
cord-006702-ekf6mja9	1311	23	children	child	NNS
cord-006702-ekf6mja9	1311	24	Kamei	Kamei	NNP
cord-006702-ekf6mja9	1311	25	(	(	-LRB-
cord-006702-ekf6mja9	1311	26	3	3	CD
cord-006702-ekf6mja9	1311	27	)	)	-RRB-
cord-006702-ekf6mja9	1311	28	,	,	,
cord-006702-ekf6mja9	1311	29	S.	S.	NNP
cord-006702-ekf6mja9	1311	30	Ito	Ito	NNP
cord-006702-ekf6mja9	1311	31	(	(	-LRB-
cord-006702-ekf6mja9	1311	32	4	4	CD
cord-006702-ekf6mja9	1311	33	)	)	-RRB-
cord-006702-ekf6mja9	1311	34	,	,	,
cord-006702-ekf6mja9	1311	35	K.	K.	NNP
cord-006702-ekf6mja9	1311	36	Ishikura	Ishikura	NNP
cord-006702-ekf6mja9	1311	37	(	(	-LRB-
cord-006702-ekf6mja9	1311	38	3	3	CD
cord-006702-ekf6mja9	1311	39	)	)	-RRB-
cord-006702-ekf6mja9	1311	40	(	(	-LRB-
cord-006702-ekf6mja9	1311	41	1	1	LS
cord-006702-ekf6mja9	1311	42	)	)	-RRB-
cord-006702-ekf6mja9	1311	43	Department	Department	NNP
cord-006702-ekf6mja9	1311	44	of	of	IN
cord-006702-ekf6mja9	1311	45	Pediatrics	Pediatrics	NNP
cord-006702-ekf6mja9	1312	1	Mycophenolate	Mycophenolate	NNP
cord-006702-ekf6mja9	1312	2	Mofetil	Mofetil	NNP
cord-006702-ekf6mja9	1312	3	(	(	-LRB-
cord-006702-ekf6mja9	1312	4	MMF	MMF	NNP
cord-006702-ekf6mja9	1312	5	)	)	-RRB-
cord-006702-ekf6mja9	1312	6	as	as	IN
cord-006702-ekf6mja9	1312	7	induction	induction	NN
cord-006702-ekf6mja9	1312	8	and	and	CC
cord-006702-ekf6mja9	1312	9	maintenance	maintenance	NN
cord-006702-ekf6mja9	1312	10	therapy	therapy	NN
cord-006702-ekf6mja9	1312	11	in	in	IN
cord-006702-ekf6mja9	1312	12	childhood	childhood	NN
cord-006702-ekf6mja9	1312	13	Lupus	Lupus	NNP
cord-006702-ekf6mja9	1312	14	Nephritis	nephritis	NN
cord-006702-ekf6mja9	1313	1	(	(	-LRB-
cord-006702-ekf6mja9	1313	2	LN	LN	NNP
cord-006702-ekf6mja9	1313	3	)	)	-RRB-
cord-006702-ekf6mja9	1313	4	F.	F.	NNP
cord-006702-ekf6mja9	1313	5	Nuzzi	Nuzzi	NNP
cord-006702-ekf6mja9	1313	6	(	(	-LRB-
cord-006702-ekf6mja9	1313	7	2	2	CD
cord-006702-ekf6mja9	1313	8	)	)	-RRB-
cord-006702-ekf6mja9	1313	9	,	,	,
cord-006702-ekf6mja9	1313	10	M.M.	M.M.	NNP
cord-006702-ekf6mja9	1313	11	Balletta	Balletta	NNP
cord-006702-ekf6mja9	1313	12	(	(	-LRB-
cord-006702-ekf6mja9	1313	13	1	1	CD
cord-006702-ekf6mja9	1313	14	)	)	-RRB-
cord-006702-ekf6mja9	1313	15	,	,	,
cord-006702-ekf6mja9	1313	16	G.	G.	NNP
cord-006702-ekf6mja9	1313	17	Malgieri	Malgieri	NNP
cord-006702-ekf6mja9	1313	18	(	(	-LRB-
cord-006702-ekf6mja9	1313	19	2	2	CD
cord-006702-ekf6mja9	1313	20	)	)	-RRB-
cord-006702-ekf6mja9	1313	21	,	,	,
cord-006702-ekf6mja9	1313	22	M.	M.	NNP
cord-006702-ekf6mja9	1313	23	D'Armiento	D'Armiento	NNP
cord-006702-ekf6mja9	1313	24	(	(	-LRB-
cord-006702-ekf6mja9	1313	25	1	1	CD
cord-006702-ekf6mja9	1313	26	)	)	-RRB-
cord-006702-ekf6mja9	1313	27	Histologic	Histologic	NNP
cord-006702-ekf6mja9	1313	28	classes	class	NNS
cord-006702-ekf6mja9	1313	29	(	(	-LRB-
cord-006702-ekf6mja9	1313	30	Weening	Weening	NNP
cord-006702-ekf6mja9	1313	31	)	)	-RRB-
cord-006702-ekf6mja9	1313	32	were	be	VBD
cord-006702-ekf6mja9	1313	33	:	:	:
cord-006702-ekf6mja9	1313	34	II	II	NNP
cord-006702-ekf6mja9	1313	35	in	in	IN
cord-006702-ekf6mja9	1313	36	9	9	CD
cord-006702-ekf6mja9	1313	37	pts	pt	NNS
cord-006702-ekf6mja9	1313	38	,	,	,
cord-006702-ekf6mja9	1313	39	III	III	NNP
cord-006702-ekf6mja9	1313	40	in	in	IN
cord-006702-ekf6mja9	1313	41	7	7	CD
cord-006702-ekf6mja9	1313	42	,	,	,
cord-006702-ekf6mja9	1313	43	IV	IV	NNP
cord-006702-ekf6mja9	1313	44	in	in	IN
cord-006702-ekf6mja9	1313	45	18	18	CD
cord-006702-ekf6mja9	1313	46	,	,	,
cord-006702-ekf6mja9	1313	47	V	v	NN
cord-006702-ekf6mja9	1313	48	in	in	IN
cord-006702-ekf6mja9	1313	49	5	5	CD
cord-006702-ekf6mja9	1313	50	.	.	.
cord-006702-ekf6mja9	1314	1	Before	before	IN
cord-006702-ekf6mja9	1314	2	MMF	mmf	NN
cord-006702-ekf6mja9	1314	3	,	,	,
cord-006702-ekf6mja9	1314	4	Methylprednisolone	Methylprednisolone	NNP
cord-006702-ekf6mja9	1314	5	i.v	i.v	NNP
cord-006702-ekf6mja9	1314	6	.	.	NNP
cord-006702-ekf6mja9	1314	7	pulses	pulse	NNS
cord-006702-ekf6mja9	1314	8	were	be	VBD
cord-006702-ekf6mja9	1314	9	administered	administer	VBN
cord-006702-ekf6mja9	1314	10	.	.	.
cord-006702-ekf6mja9	1315	1	Hematuria	Hematuria	NNP
cord-006702-ekf6mja9	1315	2	was	be	VBD
cord-006702-ekf6mja9	1315	3	always	always	RB
cord-006702-ekf6mja9	1315	4	present	present	JJ
cord-006702-ekf6mja9	1315	5	,	,	,
cord-006702-ekf6mja9	1315	6	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1315	7	ranged	range	VBD
cord-006702-ekf6mja9	1315	8	from	from	IN
cord-006702-ekf6mja9	1315	9	1.7	1.7	CD
cord-006702-ekf6mja9	1315	10	to	to	IN
cord-006702-ekf6mja9	1315	11	>	>	XX
cord-006702-ekf6mja9	1315	12	9	9	CD
cord-006702-ekf6mja9	1315	13	g	g	NN
cord-006702-ekf6mja9	1315	14	/	/	SYM
cord-006702-ekf6mja9	1315	15	day	day	NN
cord-006702-ekf6mja9	1315	16	,	,	,
cord-006702-ekf6mja9	1315	17	decreased	decrease	VBD
cord-006702-ekf6mja9	1315	18	C3	c3	NN
cord-006702-ekf6mja9	1315	19	and	and	CC
cord-006702-ekf6mja9	1315	20	increase	increase	NN
cord-006702-ekf6mja9	1315	21	in	in	IN
cord-006702-ekf6mja9	1315	22	anti	anti	JJ
cord-006702-ekf6mja9	1315	23	-	-	JJ
cord-006702-ekf6mja9	1315	24	dsDNA	dsdna	JJ
cord-006702-ekf6mja9	1315	25	ab	ab	NNP
cord-006702-ekf6mja9	1315	26	were	be	VBD
cord-006702-ekf6mja9	1315	27	present	present	JJ
cord-006702-ekf6mja9	1315	28	.	.	.
cord-006702-ekf6mja9	1316	1	Treatment	treatment	NN
cord-006702-ekf6mja9	1316	2	outcome	outcome	NN
cord-006702-ekf6mja9	1316	3	was	be	VBD
cord-006702-ekf6mja9	1316	4	monitored	monitor	VBN
cord-006702-ekf6mja9	1316	5	through	through	IN
cord-006702-ekf6mja9	1316	6	assessment	assessment	NN
cord-006702-ekf6mja9	1316	7	of	of	IN
cord-006702-ekf6mja9	1316	8	SLEDAI	SLEDAI	NNP
cord-006702-ekf6mja9	1316	9	score	score	NN
cord-006702-ekf6mja9	1316	10	,	,	,
cord-006702-ekf6mja9	1316	11	renal	renal	JJ
cord-006702-ekf6mja9	1316	12	function	function	NN
cord-006702-ekf6mja9	1316	13	,	,	,
cord-006702-ekf6mja9	1316	14	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1316	15	,	,	,
cord-006702-ekf6mja9	1316	16	serological	serological	JJ
cord-006702-ekf6mja9	1316	17	markers	marker	NNS
cord-006702-ekf6mja9	1316	18	and	and	CC
cord-006702-ekf6mja9	1316	19	side	side	NN
cord-006702-ekf6mja9	1316	20	effects	effect	NNS
cord-006702-ekf6mja9	1316	21	.	.	.
cord-006702-ekf6mja9	1317	1	MMF	MMF	NNP
cord-006702-ekf6mja9	1317	2	was	be	VBD
cord-006702-ekf6mja9	1317	3	administered	administer	VBN
cord-006702-ekf6mja9	1317	4	twice	twice	RB
cord-006702-ekf6mja9	1317	5	daily	daily	RB
cord-006702-ekf6mja9	1317	6	at	at	IN
cord-006702-ekf6mja9	1317	7	mean	mean	JJ
cord-006702-ekf6mja9	1317	8	dose	dose	NNP
cord-006702-ekf6mja9	1317	9	29	29	CD
cord-006702-ekf6mja9	1317	10	/	/	SYM
cord-006702-ekf6mja9	1317	11	mg	mg	NNP
cord-006702-ekf6mja9	1317	12	/	/	SYM
cord-006702-ekf6mja9	1317	13	Kg	Kg	NNP
cord-006702-ekf6mja9	1317	14	/	/	SYM
cord-006702-ekf6mja9	1317	15	day	day	NN
cord-006702-ekf6mja9	1317	16	.	.	.
cord-006702-ekf6mja9	1318	1	Oral	oral	JJ
cord-006702-ekf6mja9	1318	2	prednisone	prednisone	NN
cord-006702-ekf6mja9	1318	3	(	(	-LRB-
cord-006702-ekf6mja9	1318	4	P	p	NN
cord-006702-ekf6mja9	1318	5	)	)	-RRB-
cord-006702-ekf6mja9	1318	6	was	be	VBD
cord-006702-ekf6mja9	1318	7	associated	associate	VBN
cord-006702-ekf6mja9	1318	8	to	to	IN
cord-006702-ekf6mja9	1318	9	MMF	MMF	NNP
cord-006702-ekf6mja9	1318	10	.	.	.
cord-006702-ekf6mja9	1319	1	Results	result	NNS
cord-006702-ekf6mja9	1319	2	:	:	:
cord-006702-ekf6mja9	1320	1	After	after	IN
cord-006702-ekf6mja9	1320	2	a	a	DT
cord-006702-ekf6mja9	1320	3	mean	mean	JJ
cord-006702-ekf6mja9	1320	4	followup	followup	JJ
cord-006702-ekf6mja9	1320	5	4.5	4.5	CD
cord-006702-ekf6mja9	1320	6	yrs	yr	NNS
cord-006702-ekf6mja9	1320	7	(	(	-LRB-
cord-006702-ekf6mja9	1320	8	0.5	0.5	CD
cord-006702-ekf6mja9	1320	9	-	-	SYM
cord-006702-ekf6mja9	1320	10	8.3	8.3	CD
cord-006702-ekf6mja9	1320	11	)	)	-RRB-
cord-006702-ekf6mja9	1321	1	all	all	DT
cord-006702-ekf6mja9	1321	2	pts	pt	NNS
cord-006702-ekf6mja9	1321	3	had	have	VBD
cord-006702-ekf6mja9	1321	4	sustained	sustain	VBN
cord-006702-ekf6mja9	1321	5	remission	remission	NN
cord-006702-ekf6mja9	1321	6	:	:	:
cord-006702-ekf6mja9	1321	7	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1321	8	was	be	VBD
cord-006702-ekf6mja9	1321	9	absent	absent	JJ
cord-006702-ekf6mja9	1321	10	or	or	CC
cord-006702-ekf6mja9	1321	11	<	<	XX
cord-006702-ekf6mja9	1322	1	0.5g	0.5g	LS
cord-006702-ekf6mja9	1322	2	/	/	SYM
cord-006702-ekf6mja9	1322	3	day	day	NN
cord-006702-ekf6mja9	1322	4	in	in	IN
cord-006702-ekf6mja9	1322	5	23	23	CD
cord-006702-ekf6mja9	1322	6	,	,	,
cord-006702-ekf6mja9	1322	7	0.5	0.5	CD
cord-006702-ekf6mja9	1322	8	-	-	HYPH
cord-006702-ekf6mja9	1322	9	1.0g	1.0g	CD
cord-006702-ekf6mja9	1322	10	/	/	SYM
cord-006702-ekf6mja9	1322	11	day	day	NN
cord-006702-ekf6mja9	1322	12	in	in	IN
cord-006702-ekf6mja9	1322	13	15	15	CD
cord-006702-ekf6mja9	1322	14	,	,	,
cord-006702-ekf6mja9	1323	1	>	>	XX
cord-006702-ekf6mja9	1324	1	1	1	CD
cord-006702-ekf6mja9	1324	2	g	g	NN
cord-006702-ekf6mja9	1324	3	in	in	IN
cord-006702-ekf6mja9	1324	4	3	3	CD
cord-006702-ekf6mja9	1324	5	.	.	.
cord-006702-ekf6mja9	1325	1	;	;	:
cord-006702-ekf6mja9	1325	2	all	all	DT
cord-006702-ekf6mja9	1325	3	but	but	IN
cord-006702-ekf6mja9	1325	4	one	one	CD
cord-006702-ekf6mja9	1325	5	of	of	IN
cord-006702-ekf6mja9	1325	6	9	9	CD
cord-006702-ekf6mja9	1325	7	children	child	NNS
cord-006702-ekf6mja9	1325	8	with	with	IN
cord-006702-ekf6mja9	1325	9	renal	renal	JJ
cord-006702-ekf6mja9	1325	10	failure	failure	NN
cord-006702-ekf6mja9	1325	11	at	at	IN
cord-006702-ekf6mja9	1325	12	onset	onset	NN
cord-006702-ekf6mja9	1325	13	normalized	normalize	VBN
cord-006702-ekf6mja9	1325	14	;	;	:
cord-006702-ekf6mja9	1325	15	C3	C3	NNP
cord-006702-ekf6mja9	1325	16	mormalized	mormalize	VBD
cord-006702-ekf6mja9	1325	17	in	in	IN
cord-006702-ekf6mja9	1325	18	25	25	CD
cord-006702-ekf6mja9	1325	19	(	(	-LRB-
cord-006702-ekf6mja9	1325	20	61	61	CD
cord-006702-ekf6mja9	1325	21	%	%	NN
cord-006702-ekf6mja9	1325	22	)	)	-RRB-
cord-006702-ekf6mja9	1325	23	.	.	.
cord-006702-ekf6mja9	1326	1	A	a	DT
cord-006702-ekf6mja9	1326	2	steroid	steroid	NN
cord-006702-ekf6mja9	1326	3	sparing	sparing	NN
cord-006702-ekf6mja9	1326	4	effect	effect	NN
cord-006702-ekf6mja9	1326	5	(	(	-LRB-
cord-006702-ekf6mja9	1326	6	P	p	NN
cord-006702-ekf6mja9	1326	7	maintenance	maintenance	NN
cord-006702-ekf6mja9	1326	8	dose	dose	NN
cord-006702-ekf6mja9	1326	9	0.3	0.3	CD
cord-006702-ekf6mja9	1326	10	mg	mg	NNP
cord-006702-ekf6mja9	1326	11	/	/	SYM
cord-006702-ekf6mja9	1326	12	Kg	Kg	NNP
cord-006702-ekf6mja9	1326	13	/	/	SYM
cord-006702-ekf6mja9	1326	14	alternate	alternate	JJ
cord-006702-ekf6mja9	1326	15	day	day	NN
cord-006702-ekf6mja9	1326	16	in	in	IN
cord-006702-ekf6mja9	1326	17	27	27	CD
cord-006702-ekf6mja9	1326	18	pts	pt	NNS
cord-006702-ekf6mja9	1326	19	)	)	-RRB-
cord-006702-ekf6mja9	1326	20	.	.	.
cord-006702-ekf6mja9	1327	1	Until	until	IN
cord-006702-ekf6mja9	1327	2	now	now	RB
cord-006702-ekf6mja9	1327	3	6	6	CD
cord-006702-ekf6mja9	1327	4	pts	pt	NNS
cord-006702-ekf6mja9	1327	5	are	be	VBP
cord-006702-ekf6mja9	1327	6	off	off	IN
cord-006702-ekf6mja9	1327	7	therapy	therapy	NN
cord-006702-ekf6mja9	1327	8	from	from	IN
cord-006702-ekf6mja9	1327	9	1.7	1.7	CD
cord-006702-ekf6mja9	1327	10	yrs	yr	NNS
cord-006702-ekf6mja9	1327	11	mean	mean	VBP
cord-006702-ekf6mja9	1327	12	period	period	NN
cord-006702-ekf6mja9	1327	13	(	(	-LRB-
cord-006702-ekf6mja9	1327	14	0.8	0.8	CD
cord-006702-ekf6mja9	1327	15	-	-	SYM
cord-006702-ekf6mja9	1327	16	3.2	3.2	CD
cord-006702-ekf6mja9	1327	17	)	)	-RRB-
cord-006702-ekf6mja9	1327	18	after	after	IN
cord-006702-ekf6mja9	1327	19	at	at	RB
cord-006702-ekf6mja9	1327	20	least	least	JJS
cord-006702-ekf6mja9	1327	21	4	4	CD
cord-006702-ekf6mja9	1327	22	yrs	yrs	NN
cord-006702-ekf6mja9	1327	23	therapy	therapy	NN
cord-006702-ekf6mja9	1327	24	,	,	,
cord-006702-ekf6mja9	1327	25	no	no	DT
cord-006702-ekf6mja9	1327	26	flares	flare	NNS
cord-006702-ekf6mja9	1327	27	from	from	IN
cord-006702-ekf6mja9	1327	28	3yrs	3yrs	NNP
cord-006702-ekf6mja9	1327	29	,	,	,
cord-006702-ekf6mja9	1327	30	proteinuria	proteinuria	NN
cord-006702-ekf6mja9	1328	1	<	<	XX
cord-006702-ekf6mja9	1328	2	1	1	CD
cord-006702-ekf6mja9	1328	3	g	g	NNP
cord-006702-ekf6mja9	1328	4	/	/	SYM
cord-006702-ekf6mja9	1328	5	day	day	NN
cord-006702-ekf6mja9	1328	6	,	,	,
cord-006702-ekf6mja9	1328	7	normal	normal	JJ
cord-006702-ekf6mja9	1328	8	pCreat	pCreat	NNP
cord-006702-ekf6mja9	1328	9	,	,	,
cord-006702-ekf6mja9	1328	10	inactive	inactive	JJ
cord-006702-ekf6mja9	1328	11	urinary	urinary	JJ
cord-006702-ekf6mja9	1328	12	sediment	sediment	NN
cord-006702-ekf6mja9	1328	13	.	.	.
cord-006702-ekf6mja9	1329	1	In	in	IN
cord-006702-ekf6mja9	1329	2	10	10	CD
cord-006702-ekf6mja9	1329	3	pts	pt	NNS
cord-006702-ekf6mja9	1329	4	a	a	DT
cord-006702-ekf6mja9	1329	5	second	second	JJ
cord-006702-ekf6mja9	1329	6	serial	serial	JJ
cord-006702-ekf6mja9	1329	7	renal	renal	JJ
cord-006702-ekf6mja9	1329	8	biopsy	biopsy	NN
cord-006702-ekf6mja9	1329	9	,	,	,
cord-006702-ekf6mja9	1329	10	after	after	IN
cord-006702-ekf6mja9	1329	11	2	2	CD
cord-006702-ekf6mja9	1329	12	yrs	yr	NNS
cord-006702-ekf6mja9	1329	13	,	,	,
cord-006702-ekf6mja9	1329	14	showed	show	VBD
cord-006702-ekf6mja9	1329	15	decrease	decrease	NN
cord-006702-ekf6mja9	1329	16	of	of	IN
cord-006702-ekf6mja9	1329	17	activity	activity	NN
cord-006702-ekf6mja9	1329	18	indexes	index	NNS
cord-006702-ekf6mja9	1329	19	,	,	,
cord-006702-ekf6mja9	1329	20	chronicity	chronicity	NN
cord-006702-ekf6mja9	1329	21	indexes	index	NNS
cord-006702-ekf6mja9	1329	22	did	do	VBD
cord-006702-ekf6mja9	1329	23	not	not	RB
cord-006702-ekf6mja9	1329	24	change	change	VB
cord-006702-ekf6mja9	1329	25	.	.	.
cord-006702-ekf6mja9	1330	1	No	no	DT
cord-006702-ekf6mja9	1330	2	hematological	hematological	JJ
cord-006702-ekf6mja9	1330	3	side	side	NN
cord-006702-ekf6mja9	1330	4	effects	effect	NNS
cord-006702-ekf6mja9	1330	5	were	be	VBD
cord-006702-ekf6mja9	1330	6	seen	see	VBN
cord-006702-ekf6mja9	1330	7	;	;	:
cord-006702-ekf6mja9	1330	8	because	because	IN
cord-006702-ekf6mja9	1330	9	of	of	IN
cord-006702-ekf6mja9	1330	10	gastrointestinal	gastrointestinal	JJ
cord-006702-ekf6mja9	1330	11	signs	sign	NNS
cord-006702-ekf6mja9	1330	12	in	in	IN
cord-006702-ekf6mja9	1330	13	6	6	CD
cord-006702-ekf6mja9	1330	14	pts	pt	NNS
cord-006702-ekf6mja9	1330	15	,	,	,
cord-006702-ekf6mja9	1330	16	MMF	MMF	NNP
cord-006702-ekf6mja9	1330	17	was	be	VBD
cord-006702-ekf6mja9	1330	18	shifted	shift	VBN
cord-006702-ekf6mja9	1330	19	to	to	IN
cord-006702-ekf6mja9	1330	20	gastroresistant	gastroresistant	JJ
cord-006702-ekf6mja9	1330	21	formula	formula	NN
cord-006702-ekf6mja9	1330	22	;	;	:
cord-006702-ekf6mja9	1330	23	one	one	CD
cord-006702-ekf6mja9	1330	24	pt	pt	NN
cord-006702-ekf6mja9	1330	25	had	have	VBD
cord-006702-ekf6mja9	1330	26	Herpes	Herpes	NNP
cord-006702-ekf6mja9	1330	27	Zoster	Zoster	NNP
cord-006702-ekf6mja9	1330	28	infection	infection	NN
cord-006702-ekf6mja9	1330	29	S35	S35	NNP
cord-006702-ekf6mja9	1331	1	-Complications	-complication	NNS
cord-006702-ekf6mja9	1331	2	following	follow	VBG
cord-006702-ekf6mja9	1331	3	renal	renal	JJ
cord-006702-ekf6mja9	1331	4	transplantation	transplantation	NN
cord-006702-ekf6mja9	1331	5	FP	FP	NNP
cord-006702-ekf6mja9	1331	6	-	-	HYPH
cord-006702-ekf6mja9	1331	7	S35	S35	NNP
cord-006702-ekf6mja9	1331	8	-	-	HYPH
cord-006702-ekf6mja9	1331	9	1	1	CD
cord-006702-ekf6mja9	1331	10	Post	Post	NNP
cord-006702-ekf6mja9	1331	11	-	-	NNP
cord-006702-ekf6mja9	1331	12	Transplant	Transplant	NNP
cord-006702-ekf6mja9	1331	13	Acute	acute	JJ
cord-006702-ekf6mja9	1331	14	Kidney	kidney	NN
cord-006702-ekf6mja9	1331	15	Injury	injury	NN
cord-006702-ekf6mja9	1331	16	(	(	-LRB-
cord-006702-ekf6mja9	1331	17	AKI	AKI	NNP
cord-006702-ekf6mja9	1331	18	)	)	-RRB-
cord-006702-ekf6mja9	1331	19	Predicts	predict	VBZ
cord-006702-ekf6mja9	1331	20	Development	Development	NNP
cord-006702-ekf6mja9	1331	21	of	of	IN
cord-006702-ekf6mja9	1331	22	Chronic	Chronic	NNP
cord-006702-ekf6mja9	1331	23	Kidney	Kidney	NNP
cord-006702-ekf6mja9	1331	24	Disease	Disease	NNP
cord-006702-ekf6mja9	1331	25	(	(	-LRB-
cord-006702-ekf6mja9	1331	26	CKD	CKD	NNP
cord-006702-ekf6mja9	1331	27	)	)	-RRB-
cord-006702-ekf6mja9	1331	28	in	in	IN
cord-006702-ekf6mja9	1331	29	Paediatric	Paediatric	NNP
cord-006702-ekf6mja9	1331	30	Non	Non	NNP
cord-006702-ekf6mja9	1331	31	-	-	JJ
cord-006702-ekf6mja9	1331	32	Kidney	kidney	JJ
cord-006702-ekf6mja9	1331	33	Transplant	Transplant	NNP
cord-006702-ekf6mja9	1331	34	Recipients	Recipients	NNP
cord-006702-ekf6mja9	1331	35	C.	C.	NNP
cord-006702-ekf6mja9	1331	36	Williams	Williams	NNP
cord-006702-ekf6mja9	1331	37	(	(	-LRB-
cord-006702-ekf6mja9	1331	38	1	1	CD
cord-006702-ekf6mja9	1331	39	)	)	-RRB-
cord-006702-ekf6mja9	1331	40	,	,	,
cord-006702-ekf6mja9	1331	41	K.	K.	NNP
cord-006702-ekf6mja9	1331	42	Borges	Borges	NNP
cord-006702-ekf6mja9	1331	43	(	(	-LRB-
cord-006702-ekf6mja9	1331	44	1	1	CD
cord-006702-ekf6mja9	1331	45	)	)	-RRB-
cord-006702-ekf6mja9	1331	46	,	,	,
cord-006702-ekf6mja9	1331	47	T.	T.	NNP
cord-006702-ekf6mja9	1331	48	Banh	Banh	NNP
cord-006702-ekf6mja9	1331	49	(	(	-LRB-
cord-006702-ekf6mja9	1331	50	1	1	CD
cord-006702-ekf6mja9	1331	51	)	)	-RRB-
cord-006702-ekf6mja9	1332	1	AKI	AKI	NNP
cord-006702-ekf6mja9	1332	2	status	status	NN
cord-006702-ekf6mja9	1332	3	(	(	-LRB-
cord-006702-ekf6mja9	1332	4	defined	define	VBN
cord-006702-ekf6mja9	1332	5	per	per	IN
cord-006702-ekf6mja9	1332	6	international	international	JJ
cord-006702-ekf6mja9	1332	7	guidelines	guideline	NNS
cord-006702-ekf6mja9	1332	8	)	)	-RRB-
cord-006702-ekf6mja9	1332	9	was	be	VBD
cord-006702-ekf6mja9	1332	10	assessed	assess	VBN
cord-006702-ekf6mja9	1332	11	at	at	IN
cord-006702-ekf6mja9	1332	12	3	3	CD
cord-006702-ekf6mja9	1332	13	,	,	,
cord-006702-ekf6mja9	1332	14	6	6	CD
cord-006702-ekf6mja9	1332	15	and	and	CC
cord-006702-ekf6mja9	1332	16	12	12	CD
cord-006702-ekf6mja9	1332	17	months	month	NNS
cord-006702-ekf6mja9	1332	18	post	post	NN
cord-006702-ekf6mja9	1332	19	-	-	NN
cord-006702-ekf6mja9	1332	20	transplant	transplant	NN
cord-006702-ekf6mja9	1332	21	.	.	.
cord-006702-ekf6mja9	1333	1	Patients	patient	NNS
cord-006702-ekf6mja9	1333	2	were	be	VBD
cord-006702-ekf6mja9	1333	3	followed	follow	VBN
cord-006702-ekf6mja9	1333	4	until	until	IN
cord-006702-ekf6mja9	1333	5	CKD	CKD	NNP
cord-006702-ekf6mja9	1333	6	(	(	-LRB-
cord-006702-ekf6mja9	1333	7	creatinine	creatinine	NN
cord-006702-ekf6mja9	1333	8	-	-	HYPH
cord-006702-ekf6mja9	1333	9	based	base	VBN
cord-006702-ekf6mja9	1333	10	estimated	estimate	VBN
cord-006702-ekf6mja9	1333	11	glomerular	glomerular	JJ
cord-006702-ekf6mja9	1333	12	filtration	filtration	NN
cord-006702-ekf6mja9	1333	13	rate	rate	NN
cord-006702-ekf6mja9	1333	14	(	(	-LRB-
cord-006702-ekf6mja9	1333	15	eGFR	egfr	NN
cord-006702-ekf6mja9	1333	16	)	)	-RRB-
cord-006702-ekf6mja9	1334	1	<	<	XX
cord-006702-ekf6mja9	1334	2	60	60	CD
cord-006702-ekf6mja9	1335	1	mL/	mL/	NNP
cord-006702-ekf6mja9	1335	2	min	min	NNP
cord-006702-ekf6mja9	1335	3	/	/	SYM
cord-006702-ekf6mja9	1335	4	m	m	NNP
cord-006702-ekf6mja9	1335	5	2	2	CD
cord-006702-ekf6mja9	1335	6	for	for	IN
cord-006702-ekf6mja9	1335	7	6	6	CD
cord-006702-ekf6mja9	1335	8	months	month	NNS
cord-006702-ekf6mja9	1335	9	)	)	-RRB-
cord-006702-ekf6mja9	1335	10	,	,	.
cord-006702-ekf6mja9	1336	1	end	end	NN
cord-006702-ekf6mja9	1336	2	stage	stage	NN
cord-006702-ekf6mja9	1336	3	renal	renal	JJ
cord-006702-ekf6mja9	1336	4	disease	disease	NN
cord-006702-ekf6mja9	1336	5	(	(	-LRB-
cord-006702-ekf6mja9	1336	6	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1336	7	,	,	,
cord-006702-ekf6mja9	1336	8	initiation	initiation	NN
cord-006702-ekf6mja9	1336	9	of	of	IN
cord-006702-ekf6mja9	1336	10	dialysis	dialysis	NN
cord-006702-ekf6mja9	1336	11	or	or	CC
cord-006702-ekf6mja9	1336	12	receipt	receipt	NN
cord-006702-ekf6mja9	1336	13	of	of	IN
cord-006702-ekf6mja9	1336	14	a	a	DT
cord-006702-ekf6mja9	1336	15	kidney	kidney	NN
cord-006702-ekf6mja9	1336	16	transplant	transplant	NN
cord-006702-ekf6mja9	1336	17	)	)	-RRB-
cord-006702-ekf6mja9	1336	18	or	or	CC
cord-006702-ekf6mja9	1336	19	last	last	JJ
cord-006702-ekf6mja9	1336	20	follow	follow	NN
cord-006702-ekf6mja9	1336	21	-	-	HYPH
cord-006702-ekf6mja9	1336	22	up	up	NN
cord-006702-ekf6mja9	1336	23	.	.	.
cord-006702-ekf6mja9	1337	1	Those	those	DT
cord-006702-ekf6mja9	1337	2	who	who	WP
cord-006702-ekf6mja9	1337	3	received	receive	VBD
cord-006702-ekf6mja9	1337	4	dialysis	dialysis	NN
cord-006702-ekf6mja9	1337	5	prior	prior	RB
cord-006702-ekf6mja9	1337	6	to	to	IN
cord-006702-ekf6mja9	1337	7	transplant	transplant	NN
cord-006702-ekf6mja9	1337	8	or	or	CC
cord-006702-ekf6mja9	1337	9	were	be	VBD
cord-006702-ekf6mja9	1337	10	followed	follow	VBN
cord-006702-ekf6mja9	1337	11	<	<	XX
cord-006702-ekf6mja9	1337	12	90	90	CD
cord-006702-ekf6mja9	1337	13	days	day	NNS
cord-006702-ekf6mja9	1337	14	were	be	VBD
cord-006702-ekf6mja9	1337	15	excluded	exclude	VBN
cord-006702-ekf6mja9	1337	16	.	.	.
cord-006702-ekf6mja9	1338	1	Risk	risk	NN
cord-006702-ekf6mja9	1338	2	of	of	IN
cord-006702-ekf6mja9	1338	3	CKD	CKD	NNP
cord-006702-ekf6mja9	1338	4	as	as	IN
cord-006702-ekf6mja9	1338	5	a	a	DT
cord-006702-ekf6mja9	1338	6	function	function	NN
cord-006702-ekf6mja9	1338	7	of	of	IN
cord-006702-ekf6mja9	1338	8	AKI	AKI	NNP
cord-006702-ekf6mja9	1338	9	and	and	CC
cord-006702-ekf6mja9	1338	10	other	other	JJ
cord-006702-ekf6mja9	1338	11	covariates	covariate	NNS
cord-006702-ekf6mja9	1338	12	was	be	VBD
cord-006702-ekf6mja9	1338	13	evaluated	evaluate	VBN
cord-006702-ekf6mja9	1338	14	in	in	IN
cord-006702-ekf6mja9	1338	15	Cox	Cox	NNP
cord-006702-ekf6mja9	1338	16	regression	regression	NN
cord-006702-ekf6mja9	1338	17	models	model	NNS
cord-006702-ekf6mja9	1338	18	.	.	.
cord-006702-ekf6mja9	1339	1	Results	result	NNS
cord-006702-ekf6mja9	1339	2	:	:	:
cord-006702-ekf6mja9	1340	1	A	a	DT
cord-006702-ekf6mja9	1340	2	total	total	NN
cord-006702-ekf6mja9	1340	3	of	of	IN
cord-006702-ekf6mja9	1340	4	304	304	CD
cord-006702-ekf6mja9	1340	5	children	child	NNS
cord-006702-ekf6mja9	1340	6	were	be	VBD
cord-006702-ekf6mja9	1340	7	transplanted	transplant	VBN
cord-006702-ekf6mja9	1340	8	at	at	IN
cord-006702-ekf6mja9	1340	9	a	a	DT
cord-006702-ekf6mja9	1340	10	median	median	JJ
cord-006702-ekf6mja9	1340	11	age	age	NN
cord-006702-ekf6mja9	1340	12	of	of	IN
cord-006702-ekf6mja9	1340	13	4.0	4.0	CD
cord-006702-ekf6mja9	1340	14	years	year	NNS
cord-006702-ekf6mja9	1341	1	(	(	-LRB-
cord-006702-ekf6mja9	1341	2	IQR:0.7	iqr:0.7	NN
cord-006702-ekf6mja9	1341	3	-	-	HYPH
cord-006702-ekf6mja9	1341	4	11.9	11.9	CD
cord-006702-ekf6mja9	1341	5	)	)	-RRB-
cord-006702-ekf6mja9	1341	6	;	;	:
cord-006702-ekf6mja9	1341	7	55	55	CD
cord-006702-ekf6mja9	1341	8	%	%	NN
cord-006702-ekf6mja9	1341	9	were	be	VBD
cord-006702-ekf6mja9	1341	10	male	male	JJ
cord-006702-ekf6mja9	1341	11	.	.	.
cord-006702-ekf6mja9	1342	1	A	a	DT
cord-006702-ekf6mja9	1342	2	total	total	NN
cord-006702-ekf6mja9	1342	3	of	of	IN
cord-006702-ekf6mja9	1342	4	88	88	CD
cord-006702-ekf6mja9	1342	5	children	child	NNS
cord-006702-ekf6mja9	1342	6	developed	develop	VBD
cord-006702-ekf6mja9	1342	7	AKI	AKI	NNP
cord-006702-ekf6mja9	1342	8	with	with	IN
cord-006702-ekf6mja9	1342	9	a	a	DT
cord-006702-ekf6mja9	1342	10	mean	mean	NN
cord-006702-ekf6mja9	1342	11	of	of	IN
cord-006702-ekf6mja9	1342	12	1.3±0.6	1.3±0.6	CD
cord-006702-ekf6mja9	1342	13	AKI	AKI	NNP
cord-006702-ekf6mja9	1342	14	episodes	episode	NNS
cord-006702-ekf6mja9	1342	15	over	over	IN
cord-006702-ekf6mja9	1342	16	the	the	DT
cord-006702-ekf6mja9	1342	17	first	first	JJ
cord-006702-ekf6mja9	1342	18	year	year	NN
cord-006702-ekf6mja9	1342	19	post	post	NN
cord-006702-ekf6mja9	1342	20	-	-	NN
cord-006702-ekf6mja9	1342	21	transplant	transplant	JJ
cord-006702-ekf6mja9	1342	22	and	and	CC
cord-006702-ekf6mja9	1342	23	24	24	CD
cord-006702-ekf6mja9	1342	24	developed	develop	VBD
cord-006702-ekf6mja9	1342	25	CKD	CKD	NNP
cord-006702-ekf6mja9	1342	26	.	.	.
cord-006702-ekf6mja9	1343	1	Less	Less	JJR
cord-006702-ekf6mja9	1343	2	than	than	IN
cord-006702-ekf6mja9	1343	3	5	5	CD
cord-006702-ekf6mja9	1343	4	children	child	NNS
cord-006702-ekf6mja9	1343	5	developed	develop	VBD
cord-006702-ekf6mja9	1343	6	ESRD	ESRD	NNP
cord-006702-ekf6mja9	1343	7	,	,	,
cord-006702-ekf6mja9	1343	8	all	all	RB
cord-006702-ekf6mja9	1343	9	within	within	IN
cord-006702-ekf6mja9	1343	10	65	65	CD
cord-006702-ekf6mja9	1343	11	days	day	NNS
cord-006702-ekf6mja9	1343	12	posttransplant	posttransplant	NN
cord-006702-ekf6mja9	1343	13	and	and	CC
cord-006702-ekf6mja9	1343	14	thus	thus	RB
cord-006702-ekf6mja9	1343	15	were	be	VBD
cord-006702-ekf6mja9	1343	16	not	not	RB
cord-006702-ekf6mja9	1343	17	included	include	VBN
cord-006702-ekf6mja9	1343	18	in	in	IN
cord-006702-ekf6mja9	1343	19	subsequent	subsequent	JJ
cord-006702-ekf6mja9	1343	20	analysis	analysis	NN
cord-006702-ekf6mja9	1343	21	.	.	.
cord-006702-ekf6mja9	1344	1	In	in	IN
cord-006702-ekf6mja9	1344	2	a	a	DT
cord-006702-ekf6mja9	1344	3	Cox	Cox	NNP
cord-006702-ekf6mja9	1344	4	regression	regression	NN
cord-006702-ekf6mja9	1344	5	model	model	NN
cord-006702-ekf6mja9	1344	6	,	,	,
cord-006702-ekf6mja9	1344	7	those	those	DT
cord-006702-ekf6mja9	1344	8	with	with	IN
cord-006702-ekf6mja9	1344	9	1	1	CD
cord-006702-ekf6mja9	1344	10	or	or	CC
cord-006702-ekf6mja9	1344	11	more	more	JJR
cord-006702-ekf6mja9	1344	12	AKI	AKI	NNP
cord-006702-ekf6mja9	1344	13	events	event	NNS
cord-006702-ekf6mja9	1344	14	versus	versus	IN
cord-006702-ekf6mja9	1344	15	no	no	DT
cord-006702-ekf6mja9	1344	16	AKI	AKI	NNP
cord-006702-ekf6mja9	1344	17	event	event	NN
cord-006702-ekf6mja9	1344	18	by	by	IN
cord-006702-ekf6mja9	1344	19	each	each	DT
cord-006702-ekf6mja9	1344	20	of	of	IN
cord-006702-ekf6mja9	1344	21	the	the	DT
cord-006702-ekf6mja9	1344	22	pre	pre	JJ
cord-006702-ekf6mja9	1344	23	-	-	JJ
cord-006702-ekf6mja9	1344	24	specified	specified	JJ
cord-006702-ekf6mja9	1344	25	time	time	NN
cord-006702-ekf6mja9	1344	26	points	point	NNS
cord-006702-ekf6mja9	1344	27	(	(	-LRB-
cord-006702-ekf6mja9	1344	28	3	3	CD
cord-006702-ekf6mja9	1344	29	months	month	NNS
cord-006702-ekf6mja9	1344	30	,	,	,
cord-006702-ekf6mja9	1344	31	6	6	CD
cord-006702-ekf6mja9	1344	32	months	month	NNS
cord-006702-ekf6mja9	1344	33	,	,	,
cord-006702-ekf6mja9	1344	34	1	1	CD
cord-006702-ekf6mja9	1344	35	year	year	NN
cord-006702-ekf6mja9	1344	36	post	post	NN
cord-006702-ekf6mja9	1344	37	-	-	JJ
cord-006702-ekf6mja9	1344	38	transplant	transplant	JJ
cord-006702-ekf6mja9	1344	39	)	)	-RRB-
cord-006702-ekf6mja9	1344	40	had	have	VBD
cord-006702-ekf6mja9	1344	41	a	a	DT
cord-006702-ekf6mja9	1344	42	significantly	significantly	RB
cord-006702-ekf6mja9	1344	43	greater	great	JJR
cord-006702-ekf6mja9	1344	44	risk	risk	NN
cord-006702-ekf6mja9	1344	45	for	for	IN
cord-006702-ekf6mja9	1344	46	developing	develop	VBG
cord-006702-ekf6mja9	1344	47	CKD	CKD	NNP
cord-006702-ekf6mja9	1344	48	over	over	IN
cord-006702-ekf6mja9	1344	49	subsequent	subsequent	JJ
cord-006702-ekf6mja9	1344	50	follow	follow	NN
cord-006702-ekf6mja9	1344	51	-	-	HYPH
cord-006702-ekf6mja9	1344	52	up	up	NN
cord-006702-ekf6mja9	1344	53	after	after	IN
cord-006702-ekf6mja9	1344	54	controlling	control	VBG
cord-006702-ekf6mja9	1344	55	for	for	IN
cord-006702-ekf6mja9	1344	56	age	age	NN
cord-006702-ekf6mja9	1344	57	,	,	,
cord-006702-ekf6mja9	1344	58	sex	sex	NN
cord-006702-ekf6mja9	1344	59	,	,	,
cord-006702-ekf6mja9	1344	60	baseline	baseline	JJ
cord-006702-ekf6mja9	1344	61	eGFR	egfr	NN
cord-006702-ekf6mja9	1344	62	.	.	.
cord-006702-ekf6mja9	1345	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1345	2	:	:	:
cord-006702-ekf6mja9	1345	3	AKI	AKI	NNP
cord-006702-ekf6mja9	1345	4	occurs	occur	VBZ
cord-006702-ekf6mja9	1345	5	commonly	commonly	RB
cord-006702-ekf6mja9	1345	6	in	in	IN
cord-006702-ekf6mja9	1345	7	the	the	DT
cord-006702-ekf6mja9	1345	8	first	first	JJ
cord-006702-ekf6mja9	1345	9	year	year	NN
cord-006702-ekf6mja9	1345	10	after	after	IN
cord-006702-ekf6mja9	1345	11	transplant	transplant	NN
cord-006702-ekf6mja9	1345	12	and	and	CC
cord-006702-ekf6mja9	1346	1	more	more	JJR
cord-006702-ekf6mja9	1346	2	than	than	IN
cord-006702-ekf6mja9	1346	3	1	1	CD
cord-006702-ekf6mja9	1346	4	episode	episode	NN
cord-006702-ekf6mja9	1346	5	of	of	IN
cord-006702-ekf6mja9	1346	6	AKI	AKI	NNP
cord-006702-ekf6mja9	1346	7	is	be	VBZ
cord-006702-ekf6mja9	1346	8	associated	associate	VBN
cord-006702-ekf6mja9	1346	9	with	with	IN
cord-006702-ekf6mja9	1346	10	2	2	CD
cord-006702-ekf6mja9	1346	11	-	-	SYM
cord-006702-ekf6mja9	1346	12	4	4	CD
cord-006702-ekf6mja9	1346	13	times	time	NNS
cord-006702-ekf6mja9	1346	14	greater	great	JJR
cord-006702-ekf6mja9	1346	15	risk	risk	NN
cord-006702-ekf6mja9	1346	16	of	of	IN
cord-006702-ekf6mja9	1346	17	developing	develop	VBG
cord-006702-ekf6mja9	1346	18	CKD	CKD	NNP
cord-006702-ekf6mja9	1346	19	FP	FP	NNP
cord-006702-ekf6mja9	1346	20	-	-	HYPH
cord-006702-ekf6mja9	1346	21	S35	S35	NNP
cord-006702-ekf6mja9	1346	22	-	-	HYPH
cord-006702-ekf6mja9	1346	23	2	2	CD
cord-006702-ekf6mja9	1346	24	Focus	Focus	NNP
cord-006702-ekf6mja9	1346	25	on	on	IN
cord-006702-ekf6mja9	1346	26	physical	physical	JJ
cord-006702-ekf6mja9	1346	27	activity	activity	NN
cord-006702-ekf6mja9	1346	28	can	can	MD
cord-006702-ekf6mja9	1346	29	improve	improve	VB
cord-006702-ekf6mja9	1346	30	cardiorespiratory	cardiorespiratory	JJ
cord-006702-ekf6mja9	1346	31	fitness	fitness	NN
cord-006702-ekf6mja9	1346	32	(	(	-LRB-
cord-006702-ekf6mja9	1346	33	VO2peak	VO2peak	NNP
cord-006702-ekf6mja9	1346	34	)	)	-RRB-
cord-006702-ekf6mja9	1346	35	in	in	IN
cord-006702-ekf6mja9	1346	36	children	child	NNS
cord-006702-ekf6mja9	1346	37	after	after	IN
cord-006702-ekf6mja9	1346	38	renal	renal	JJ
cord-006702-ekf6mja9	1346	39	transplantation	transplantation	NN
cord-006702-ekf6mja9	1346	40	H.	H.	NNP
cord-006702-ekf6mja9	1346	41	Thorsteinsdottir	Thorsteinsdottir	NNP
cord-006702-ekf6mja9	1346	42	(	(	-LRB-
cord-006702-ekf6mja9	1346	43	1	1	CD
cord-006702-ekf6mja9	1346	44	)	)	-RRB-
cord-006702-ekf6mja9	1346	45	,	,	,
cord-006702-ekf6mja9	1346	46	A.	a.	NN
cord-006702-ekf6mja9	1346	47	Lie	lie	NN
cord-006702-ekf6mja9	1346	48	(	(	-LRB-
cord-006702-ekf6mja9	1346	49	1	1	CD
cord-006702-ekf6mja9	1346	50	)	)	-RRB-
cord-006702-ekf6mja9	1346	51	,	,	.
cord-006702-ekf6mja9	1347	1	T.	T.	NNP
cord-006702-ekf6mja9	1347	2	Tangeraas	Tangeraas	NNP
cord-006702-ekf6mja9	1347	3	(	(	-LRB-
cord-006702-ekf6mja9	1347	4	1	1	CD
cord-006702-ekf6mja9	1347	5	)	)	-RRB-
cord-006702-ekf6mja9	1347	6	,	,	,
cord-006702-ekf6mja9	1347	7	A.	A.	NNP
cord-006702-ekf6mja9	1347	8	Åsberg	Åsberg	NNP
cord-006702-ekf6mja9	1347	9	)	)	-RRB-
cord-006702-ekf6mja9	1347	10	as	as	RB
cord-006702-ekf6mja9	1347	11	well	well	RB
cord-006702-ekf6mja9	1347	12	as	as	IN
cord-006702-ekf6mja9	1347	13	all	all	DT
cord-006702-ekf6mja9	1347	14	renal	renal	JJ
cord-006702-ekf6mja9	1347	15	transplanted	transplant	VBN
cord-006702-ekf6mja9	1347	16	patients	patient	NNS
cord-006702-ekf6mja9	1347	17	at	at	IN
cord-006702-ekf6mja9	1347	18	the	the	DT
cord-006702-ekf6mja9	1347	19	age	age	NN
cord-006702-ekf6mja9	1347	20	of	of	IN
cord-006702-ekf6mja9	1347	21	<	<	NNP
cord-006702-ekf6mja9	1347	22	16	16	CD
cord-006702-ekf6mja9	1347	23	yrs	yr	NNS
cord-006702-ekf6mja9	1347	24	in	in	IN
cord-006702-ekf6mja9	1347	25	the	the	DT
cord-006702-ekf6mja9	1347	26	period	period	NN
cord-006702-ekf6mja9	1347	27	2010	2010	CD
cord-006702-ekf6mja9	1347	28	-	-	SYM
cord-006702-ekf6mja9	1347	29	2015	2015	CD
cord-006702-ekf6mja9	1347	30	were	be	VBD
cord-006702-ekf6mja9	1347	31	invited	invite	VBN
cord-006702-ekf6mja9	1347	32	to	to	TO
cord-006702-ekf6mja9	1347	33	participate	participate	VB
cord-006702-ekf6mja9	1347	34	in	in	IN
cord-006702-ekf6mja9	1347	35	this	this	DT
cord-006702-ekf6mja9	1347	36	follow	follow	NN
cord-006702-ekf6mja9	1347	37	-	-	HYPH
cord-006702-ekf6mja9	1347	38	up	up	NN
cord-006702-ekf6mja9	1347	39	study	study	NN
cord-006702-ekf6mja9	1347	40	.	.	.
cord-006702-ekf6mja9	1348	1	The	the	DT
cord-006702-ekf6mja9	1348	2	participants	participant	NNS
cord-006702-ekf6mja9	1348	3	were	be	VBD
cord-006702-ekf6mja9	1348	4	tested	test	VBN
cord-006702-ekf6mja9	1348	5	on	on	IN
cord-006702-ekf6mja9	1348	6	the	the	DT
cord-006702-ekf6mja9	1348	7	treadmill	treadmill	NN
cord-006702-ekf6mja9	1348	8	(	(	-LRB-
cord-006702-ekf6mja9	1348	9	VO	VO	NNP
cord-006702-ekf6mja9	1348	10	2,max	2,max	CD
cord-006702-ekf6mja9	1348	11	)	)	-RRB-
cord-006702-ekf6mja9	1348	12	and	and	CC
cord-006702-ekf6mja9	1348	13	went	go	VBD
cord-006702-ekf6mja9	1348	14	through	through	IN
cord-006702-ekf6mja9	1348	15	a	a	DT
cord-006702-ekf6mja9	1348	16	thorough	thorough	JJ
cord-006702-ekf6mja9	1348	17	physical	physical	JJ
cord-006702-ekf6mja9	1348	18	examination	examination	NN
cord-006702-ekf6mja9	1348	19	,	,	,
cord-006702-ekf6mja9	1348	20	including	include	VBG
cord-006702-ekf6mja9	1348	21	ambulatory	ambulatory	JJ
cord-006702-ekf6mja9	1348	22	blood	blood	NN
cord-006702-ekf6mja9	1348	23	pressure	pressure	NN
cord-006702-ekf6mja9	1348	24	monitoring	monitoring	NN
cord-006702-ekf6mja9	1348	25	and	and	CC
cord-006702-ekf6mja9	1348	26	measurements	measurement	NNS
cord-006702-ekf6mja9	1348	27	of	of	IN
cord-006702-ekf6mja9	1348	28	plasma	plasma	NN
cord-006702-ekf6mja9	1348	29	lipids	lipid	NNS
cord-006702-ekf6mja9	1348	30	.	.	.
cord-006702-ekf6mja9	1349	1	The	the	DT
cord-006702-ekf6mja9	1349	2	present	present	JJ
cord-006702-ekf6mja9	1349	3	interim	interim	JJ
cord-006702-ekf6mja9	1349	4	analysis	analysis	NN
cord-006702-ekf6mja9	1349	5	is	be	VBZ
cord-006702-ekf6mja9	1349	6	performed	perform	VBN
cord-006702-ekf6mja9	1349	7	half	half	DT
cord-006702-ekf6mja9	1349	8	way	way	NN
cord-006702-ekf6mja9	1349	9	into	into	IN
cord-006702-ekf6mja9	1349	10	the	the	DT
cord-006702-ekf6mja9	1349	11	study	study	NN
cord-006702-ekf6mja9	1349	12	.	.	.
cord-006702-ekf6mja9	1350	1	Results	result	NNS
cord-006702-ekf6mja9	1350	2	:	:	:
cord-006702-ekf6mja9	1351	1	So	so	RB
cord-006702-ekf6mja9	1351	2	far	far	RB
cord-006702-ekf6mja9	1351	3	12	12	CD
cord-006702-ekf6mja9	1351	4	out	out	IN
cord-006702-ekf6mja9	1351	5	of	of	IN
cord-006702-ekf6mja9	1351	6	16	16	CD
cord-006702-ekf6mja9	1351	7	patients	patient	NNS
cord-006702-ekf6mja9	1351	8	(	(	-LRB-
cord-006702-ekf6mja9	1351	9	8	8	CD
cord-006702-ekf6mja9	1351	10	girls	girl	NNS
cord-006702-ekf6mja9	1351	11	)	)	-RRB-
cord-006702-ekf6mja9	1351	12	met	meet	VBD
cord-006702-ekf6mja9	1351	13	the	the	DT
cord-006702-ekf6mja9	1351	14	criteria	criterion	NNS
cord-006702-ekf6mja9	1351	15	for	for	IN
cord-006702-ekf6mja9	1351	16	VO	VO	NNP
cord-006702-ekf6mja9	1351	17	2,max	2,max	CD
cord-006702-ekf6mja9	1352	1	The	the	DT
cord-006702-ekf6mja9	1352	2	median	median	JJ
cord-006702-ekf6mja9	1352	3	age	age	NN
cord-006702-ekf6mja9	1352	4	at	at	IN
cord-006702-ekf6mja9	1352	5	transplant	transplant	NN
cord-006702-ekf6mja9	1352	6	was	be	VBD
cord-006702-ekf6mja9	1352	7	9.6	9.6	CD
cord-006702-ekf6mja9	1352	8	years	year	NNS
cord-006702-ekf6mja9	1353	1	(	(	-LRB-
cord-006702-ekf6mja9	1353	2	IQR=4.7	iqr=4.7	NN
cord-006702-ekf6mja9	1353	3	-	-	HYPH
cord-006702-ekf6mja9	1353	4	12.8	12.8	CD
cord-006702-ekf6mja9	1353	5	)	)	-RRB-
cord-006702-ekf6mja9	1353	6	and	and	CC
cord-006702-ekf6mja9	1353	7	the	the	DT
cord-006702-ekf6mja9	1353	8	median	median	JJ
cord-006702-ekf6mja9	1353	9	time	time	NN
cord-006702-ekf6mja9	1353	10	on	on	IN
cord-006702-ekf6mja9	1353	11	dialysis	dialysis	NN
cord-006702-ekf6mja9	1353	12	was	be	VBD
cord-006702-ekf6mja9	1353	13	19	19	CD
cord-006702-ekf6mja9	1353	14	months	month	NNS
cord-006702-ekf6mja9	1353	15	(	(	-LRB-
cord-006702-ekf6mja9	1353	16	IQR=6.5	IQR=6.5	NNP
cord-006702-ekf6mja9	1353	17	-	-	HYPH
cord-006702-ekf6mja9	1353	18	35.5	35.5	CD
cord-006702-ekf6mja9	1353	19	)	)	-RRB-
cord-006702-ekf6mja9	1353	20	.	.	.
cord-006702-ekf6mja9	1354	1	Fifty	fifty	CD
cord-006702-ekf6mja9	1354	2	-	-	HYPH
cord-006702-ekf6mja9	1354	3	eight	eight	CD
cord-006702-ekf6mja9	1354	4	patients	patient	NNS
cord-006702-ekf6mja9	1354	5	(	(	-LRB-
cord-006702-ekf6mja9	1354	6	76	76	CD
cord-006702-ekf6mja9	1354	7	%	%	NN
cord-006702-ekf6mja9	1354	8	)	)	-RRB-
cord-006702-ekf6mja9	1354	9	underwent	undergo	VBD
cord-006702-ekf6mja9	1354	10	KT	kt	NN
cord-006702-ekf6mja9	1354	11	with	with	IN
cord-006702-ekf6mja9	1354	12	deceased	deceased	JJ
cord-006702-ekf6mja9	1354	13	donor	donor	NN
cord-006702-ekf6mja9	1354	14	,	,	,
cord-006702-ekf6mja9	1354	15	the	the	DT
cord-006702-ekf6mja9	1354	16	median	median	JJ
cord-006702-ekf6mja9	1354	17	follow	follow	NN
cord-006702-ekf6mja9	1354	18	-	-	HYPH
cord-006702-ekf6mja9	1354	19	up	up	NN
cord-006702-ekf6mja9	1354	20	at	at	IN
cord-006702-ekf6mja9	1354	21	the	the	DT
cord-006702-ekf6mja9	1354	22	study	study	NN
cord-006702-ekf6mja9	1354	23	time	time	NN
cord-006702-ekf6mja9	1354	24	point	point	NN
cord-006702-ekf6mja9	1354	25	was	be	VBD
cord-006702-ekf6mja9	1354	26	3.4	3.4	CD
cord-006702-ekf6mja9	1354	27	years	year	NNS
cord-006702-ekf6mja9	1354	28	(	(	-LRB-
cord-006702-ekf6mja9	1354	29	IQR=2.2	iqr=2.2	NN
cord-006702-ekf6mja9	1354	30	-	-	HYPH
cord-006702-ekf6mja9	1354	31	4.7	4.7	CD
cord-006702-ekf6mja9	1354	32	)	)	-RRB-
cord-006702-ekf6mja9	1354	33	and	and	CC
cord-006702-ekf6mja9	1354	34	the	the	DT
cord-006702-ekf6mja9	1354	35	median	median	JJ
cord-006702-ekf6mja9	1354	36	GFR	GFR	NNP
cord-006702-ekf6mja9	1354	37	was	be	VBD
cord-006702-ekf6mja9	1354	38	63ml/	63ml/	CD
cord-006702-ekf6mja9	1355	1	min/1,72	min/1,72	NNP
cord-006702-ekf6mja9	1355	2	m	m	NN
cord-006702-ekf6mja9	1355	3	2	2	CD
cord-006702-ekf6mja9	1356	1	(	(	-LRB-
cord-006702-ekf6mja9	1356	2	IQR=48	IQR=48	NNP
cord-006702-ekf6mja9	1356	3	-	-	HYPH
cord-006702-ekf6mja9	1356	4	81	81	CD
cord-006702-ekf6mja9	1356	5	)	)	-RRB-
cord-006702-ekf6mja9	1356	6	.	.	.
cord-006702-ekf6mja9	1357	1	Only	only	RB
cord-006702-ekf6mja9	1357	2	1	1	CD
cord-006702-ekf6mja9	1357	3	child	child	NN
cord-006702-ekf6mja9	1357	4	presented	present	VBD
cord-006702-ekf6mja9	1357	5	coronary	coronary	JJ
cord-006702-ekf6mja9	1357	6	calcification	calcification	NN
cord-006702-ekf6mja9	1357	7	(	(	-LRB-
cord-006702-ekf6mja9	1357	8	1.3	1.3	CD
cord-006702-ekf6mja9	1357	9	%	%	NN
cord-006702-ekf6mja9	1357	10	)	)	-RRB-
cord-006702-ekf6mja9	1357	11	and	and	CC
cord-006702-ekf6mja9	1357	12	with	with	IN
cord-006702-ekf6mja9	1357	13	regard	regard	NN
cord-006702-ekf6mja9	1357	14	to	to	IN
cord-006702-ekf6mja9	1357	15	echocardiography	echocardiography	NN
cord-006702-ekf6mja9	1357	16	,	,	,
cord-006702-ekf6mja9	1357	17	multivariable	multivariable	JJ
cord-006702-ekf6mja9	1357	18	linear	linear	JJ
cord-006702-ekf6mja9	1357	19	regression	regression	NN
cord-006702-ekf6mja9	1357	20	revealed	reveal	VBD
cord-006702-ekf6mja9	1357	21	significant	significant	JJ
cord-006702-ekf6mja9	1357	22	association	association	NN
cord-006702-ekf6mja9	1357	23	between	between	IN
cord-006702-ekf6mja9	1357	24	the	the	DT
cord-006702-ekf6mja9	1357	25	LVM	LVM	NNP
cord-006702-ekf6mja9	1357	26	-	-	HYPH
cord-006702-ekf6mja9	1357	27	SDS	SDS	NNP
cord-006702-ekf6mja9	1357	28	and	and	CC
cord-006702-ekf6mja9	1357	29	serum	serum	NN
cord-006702-ekf6mja9	1357	30	renalase	renalase	NN
cord-006702-ekf6mja9	1357	31	(	(	-LRB-
cord-006702-ekf6mja9	1357	32	each	each	DT
cord-006702-ekf6mja9	1357	33	100	100	CD
cord-006702-ekf6mja9	1357	34	ng	ng	NN
cord-006702-ekf6mja9	1357	35	/	/	SYM
cord-006702-ekf6mja9	1357	36	mL	ml	NN
cord-006702-ekf6mja9	1357	37	increase	increase	NN
cord-006702-ekf6mja9	1357	38	in	in	IN
cord-006702-ekf6mja9	1357	39	serum	serum	NN
cord-006702-ekf6mja9	1357	40	renalase	renalase	NN
cord-006702-ekf6mja9	1357	41	is	be	VBZ
cord-006702-ekf6mja9	1357	42	associated	associate	VBN
cord-006702-ekf6mja9	1357	43	with	with	IN
cord-006702-ekf6mja9	1357	44	0.8	0.8	CD
cord-006702-ekf6mja9	1357	45	greater	great	JJR
cord-006702-ekf6mja9	1357	46	LVM	LVM	NNP
cord-006702-ekf6mja9	1357	47	-	-	HYPH
cord-006702-ekf6mja9	1357	48	SDS	SDS	NNP
cord-006702-ekf6mja9	1357	49	,	,	,
cord-006702-ekf6mja9	1357	50	p=0.005	p=0.005	NNP
cord-006702-ekf6mja9	1357	51	)	)	-RRB-
cord-006702-ekf6mja9	1357	52	and	and	CC
cord-006702-ekf6mja9	1357	53	a	a	DT
cord-006702-ekf6mja9	1357	54	trend	trend	NN
cord-006702-ekf6mja9	1357	55	of	of	IN
cord-006702-ekf6mja9	1357	56	association	association	NN
cord-006702-ekf6mja9	1357	57	with	with	IN
cord-006702-ekf6mja9	1357	58	GFR	GFR	NNP
cord-006702-ekf6mja9	1357	59	(	(	-LRB-
cord-006702-ekf6mja9	1357	60	each	each	DT
cord-006702-ekf6mja9	1357	61	10	10	CD
cord-006702-ekf6mja9	1357	62	mL	ml	NN
cord-006702-ekf6mja9	1357	63	/	/	SYM
cord-006702-ekf6mja9	1357	64	min	min	NN
cord-006702-ekf6mja9	1357	65	higher	high	JJR
cord-006702-ekf6mja9	1357	66	GFR	GFR	NNP
cord-006702-ekf6mja9	1357	67	is	be	VBZ
cord-006702-ekf6mja9	1357	68	associated	associate	VBN
cord-006702-ekf6mja9	1357	69	with	with	IN
cord-006702-ekf6mja9	1357	70	-0.13	-0.13	ADD
cord-006702-ekf6mja9	1357	71	lower	low	JJR
cord-006702-ekf6mja9	1357	72	LVM	LVM	NNP
cord-006702-ekf6mja9	1357	73	-	-	HYPH
cord-006702-ekf6mja9	1357	74	SDS	SDS	NNP
cord-006702-ekf6mja9	1357	75	,	,	,
cord-006702-ekf6mja9	1357	76	p=0.062	p=0.062	NNP
cord-006702-ekf6mja9	1357	77	)	)	-RRB-
cord-006702-ekf6mja9	1357	78	.	.	.
cord-006702-ekf6mja9	1358	1	Conclusions	conclusion	NNS
cord-006702-ekf6mja9	1358	2	:	:	:
cord-006702-ekf6mja9	1359	1	To	to	TO
cord-006702-ekf6mja9	1359	2	summarize	summarize	VB
cord-006702-ekf6mja9	1359	3	,	,	,
cord-006702-ekf6mja9	1359	4	our	-PRON-	PRP$
cord-006702-ekf6mja9	1359	5	data	datum	NNS
cord-006702-ekf6mja9	1359	6	showed	show	VBD
cord-006702-ekf6mja9	1359	7	relatively	relatively	RB
cord-006702-ekf6mja9	1359	8	good	good	JJ
cord-006702-ekf6mja9	1359	9	heart	heart	NN
cord-006702-ekf6mja9	1359	10	health	health	NN
cord-006702-ekf6mja9	1359	11	in	in	IN
cord-006702-ekf6mja9	1359	12	the	the	DT
cord-006702-ekf6mja9	1359	13	study	study	NN
cord-006702-ekf6mja9	1359	14	sample	sample	NN
cord-006702-ekf6mja9	1359	15	.	.	.
cord-006702-ekf6mja9	1360	1	These	these	DT
cord-006702-ekf6mja9	1360	2	results	result	NNS
cord-006702-ekf6mja9	1360	3	may	may	MD
cord-006702-ekf6mja9	1360	4	be	be	VB
cord-006702-ekf6mja9	1360	5	due	due	JJ
cord-006702-ekf6mja9	1360	6	to	to	IN
cord-006702-ekf6mja9	1360	7	the	the	DT
cord-006702-ekf6mja9	1360	8	young	young	JJ
cord-006702-ekf6mja9	1360	9	age	age	NN
cord-006702-ekf6mja9	1360	10	of	of	IN
cord-006702-ekf6mja9	1360	11	the	the	DT
cord-006702-ekf6mja9	1360	12	patients	patient	NNS
cord-006702-ekf6mja9	1360	13	and	and	CC
cord-006702-ekf6mja9	1360	14	the	the	DT
cord-006702-ekf6mja9	1360	15	short	short	JJ
cord-006702-ekf6mja9	1360	16	time	time	NN
cord-006702-ekf6mja9	1360	17	of	of	IN
cord-006702-ekf6mja9	1360	18	renal	renal	JJ
cord-006702-ekf6mja9	1360	19	replacement	replacement	NN
cord-006702-ekf6mja9	1360	20	therapy	therapy	NN
cord-006702-ekf6mja9	1360	21	S36	S36	NNP
cord-006702-ekf6mja9	1360	22	-Nephrocalcinosis	-Nephrocalcinosis	,
cord-006702-ekf6mja9	1360	23	&	&	CC
cord-006702-ekf6mja9	1360	24	nephrolithiasis	nephrolithiasis	NNP
cord-006702-ekf6mja9	1360	25	FP	FP	NNP
cord-006702-ekf6mja9	1360	26	-	-	HYPH
cord-006702-ekf6mja9	1360	27	S36	S36	NNP
cord-006702-ekf6mja9	1360	28	-	-	HYPH
cord-006702-ekf6mja9	1360	29	1	1	CD
cord-006702-ekf6mja9	1361	1	No	no	DT
cord-006702-ekf6mja9	1361	2	stone	stone	NN
cord-006702-ekf6mja9	1361	3	unturned	unturne	VBN
cord-006702-ekf6mja9	1361	4	:	:	:
cord-006702-ekf6mja9	1362	1	the	the	DT
cord-006702-ekf6mja9	1362	2	epidemiology	epidemiology	NN
cord-006702-ekf6mja9	1362	3	and	and	CC
cord-006702-ekf6mja9	1362	4	outcomes	outcome	NNS
cord-006702-ekf6mja9	1362	5	of	of	IN
cord-006702-ekf6mja9	1362	6	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1362	7	urolithiasis	urolithiasis	NN
cord-006702-ekf6mja9	1362	8	in	in	IN
cord-006702-ekf6mja9	1362	9	the	the	DT
cord-006702-ekf6mja9	1362	10	United	United	NNP
cord-006702-ekf6mja9	1362	11	Kingdom	Kingdom	NNP
cord-006702-ekf6mja9	1362	12	Significant	Significant	NNP
cord-006702-ekf6mja9	1362	13	family	family	NN
cord-006702-ekf6mja9	1362	14	history	history	NN
cord-006702-ekf6mja9	1362	15	was	be	VBD
cord-006702-ekf6mja9	1362	16	strongly	strongly	RB
cord-006702-ekf6mja9	1362	17	predictive	predictive	JJ
cord-006702-ekf6mja9	1362	18	of	of	IN
cord-006702-ekf6mja9	1362	19	metabolic	metabolic	JJ
cord-006702-ekf6mja9	1362	20	aetiologies	aetiology	NNS
cord-006702-ekf6mja9	1362	21	(	(	-LRB-
cord-006702-ekf6mja9	1362	22	OR	or	CC
cord-006702-ekf6mja9	1362	23	5.5:1	5.5:1	XX
cord-006702-ekf6mja9	1362	24	vs.	vs.	IN
cord-006702-ekf6mja9	1362	25	no	no	DT
cord-006702-ekf6mja9	1362	26	family	family	NN
cord-006702-ekf6mja9	1362	27	history	history	NN
cord-006702-ekf6mja9	1362	28	)	)	-RRB-
cord-006702-ekf6mja9	1362	29	.	.	.
cord-006702-ekf6mja9	1363	1	47	47	CD
cord-006702-ekf6mja9	1363	2	%	%	NN
cord-006702-ekf6mja9	1363	3	of	of	IN
cord-006702-ekf6mja9	1363	4	children	child	NNS
cord-006702-ekf6mja9	1363	5	had	have	VBD
cord-006702-ekf6mja9	1363	6	multiple	multiple	JJ
cord-006702-ekf6mja9	1363	7	aetiological	aetiological	JJ
cord-006702-ekf6mja9	1363	8	factors	factor	NNS
cord-006702-ekf6mja9	1363	9	,	,	,
cord-006702-ekf6mja9	1363	10	complicating	complicate	VBG
cord-006702-ekf6mja9	1363	11	their	-PRON-	PRP$
cord-006702-ekf6mja9	1363	12	investigation	investigation	NN
cord-006702-ekf6mja9	1363	13	and	and	CC
cord-006702-ekf6mja9	1363	14	management	management	NN
cord-006702-ekf6mja9	1363	15	.	.	.
cord-006702-ekf6mja9	1364	1	31	31	CD
cord-006702-ekf6mja9	1364	2	%	%	NN
cord-006702-ekf6mja9	1364	3	of	of	IN
cord-006702-ekf6mja9	1364	4	children	child	NNS
cord-006702-ekf6mja9	1364	5	with	with	IN
cord-006702-ekf6mja9	1364	6	≥	≥	CD
cord-006702-ekf6mja9	1364	7	4	4	CD
cord-006702-ekf6mja9	1364	8	year	year	NN
cord-006702-ekf6mja9	1364	9	follow	follow	NN
cord-006702-ekf6mja9	1364	10	-	-	HYPH
cord-006702-ekf6mja9	1364	11	up	up	NN
cord-006702-ekf6mja9	1364	12	experienced	experienced	JJ
cord-006702-ekf6mja9	1364	13	recurrence	recurrence	NN
cord-006702-ekf6mja9	1364	14	.	.	.
cord-006702-ekf6mja9	1365	1	Critically	critically	RB
cord-006702-ekf6mja9	1365	2	,	,	,
cord-006702-ekf6mja9	1365	3	we	-PRON-	PRP
cord-006702-ekf6mja9	1365	4	report	report	VBP
cord-006702-ekf6mja9	1365	5	an	an	DT
cord-006702-ekf6mja9	1365	6	association	association	NN
cord-006702-ekf6mja9	1365	7	between	between	IN
cord-006702-ekf6mja9	1365	8	paediatric	paediatric	JJ
cord-006702-ekf6mja9	1365	9	urolithiasis	urolithiasis	NN
cord-006702-ekf6mja9	1365	10	and	and	CC
cord-006702-ekf6mja9	1365	11	adverse	adverse	JJ
cord-006702-ekf6mja9	1365	12	long	long	JJ
cord-006702-ekf6mja9	1365	13	-	-	HYPH
cord-006702-ekf6mja9	1365	14	term	term	NN
cord-006702-ekf6mja9	1365	15	renal	renal	JJ
cord-006702-ekf6mja9	1365	16	outcomes	outcome	NNS
cord-006702-ekf6mja9	1365	17	.	.	.
cord-006702-ekf6mja9	1366	1	33	33	CD
cord-006702-ekf6mja9	1366	2	of	of	IN
cord-006702-ekf6mja9	1366	3	55	55	CD
cord-006702-ekf6mja9	1366	4	children	child	NNS
cord-006702-ekf6mja9	1366	5	that	that	WDT
cord-006702-ekf6mja9	1366	6	underwent	undergo	VBD
cord-006702-ekf6mja9	1366	7	DMSA	DMSA	NNS
cord-006702-ekf6mja9	1366	8	scanning	scanning	NN
cord-006702-ekf6mja9	1366	9	demonstrated	demonstrate	VBD
cord-006702-ekf6mja9	1366	10	abnormal	abnormal	JJ
cord-006702-ekf6mja9	1366	11	results	result	NNS