id sid tid token lemma pos cord-006856-b1w25ob5 1 1 key key JJ cord-006856-b1w25ob5 1 2 : : : cord-006856-b1w25ob5 1 3 cord-006856-b1w25ob5 cord-006856-b1w25ob5 NNP cord-006856-b1w25ob5 1 4 authors author NNS cord-006856-b1w25ob5 1 5 : : : cord-006856-b1w25ob5 1 6 nan nan NNP cord-006856-b1w25ob5 1 7 title title NN cord-006856-b1w25ob5 1 8 : : : cord-006856-b1w25ob5 1 9 19th 19th JJ cord-006856-b1w25ob5 1 10 Meeting Meeting NNP cord-006856-b1w25ob5 1 11 of of IN cord-006856-b1w25ob5 1 12 the the DT cord-006856-b1w25ob5 1 13 Austrian Austrian NNP cord-006856-b1w25ob5 1 14 Society Society NNP cord-006856-b1w25ob5 1 15 of of IN cord-006856-b1w25ob5 1 16 Transplantation Transplantation NNP cord-006856-b1w25ob5 1 17 , , , cord-006856-b1w25ob5 1 18 Transfusion Transfusion NNP cord-006856-b1w25ob5 1 19 , , , cord-006856-b1w25ob5 1 20 and and CC cord-006856-b1w25ob5 1 21 Genetics Genetics NNP cord-006856-b1w25ob5 1 22 , , , cord-006856-b1w25ob5 1 23 October October NNP cord-006856-b1w25ob5 1 24 26–28 26–28 CD cord-006856-b1w25ob5 1 25 , , , cord-006856-b1w25ob5 1 26 2005 2005 CD cord-006856-b1w25ob5 1 27 date date NN cord-006856-b1w25ob5 1 28 : : : cord-006856-b1w25ob5 2 1 2005 2005 CD cord-006856-b1w25ob5 2 2 journal journal NNP cord-006856-b1w25ob5 2 3 : : : cord-006856-b1w25ob5 3 1 Eur Eur NNP cord-006856-b1w25ob5 3 2 Surg Surg NNP cord-006856-b1w25ob5 3 3 DOI DOI NNP cord-006856-b1w25ob5 3 4 : : : cord-006856-b1w25ob5 3 5 10.1007 10.1007 CD cord-006856-b1w25ob5 3 6 / / SYM cord-006856-b1w25ob5 3 7 s10353 s10353 CD cord-006856-b1w25ob5 3 8 - - HYPH cord-006856-b1w25ob5 3 9 005 005 CD cord-006856-b1w25ob5 3 10 - - HYPH cord-006856-b1w25ob5 3 11 0216 0216 CD cord-006856-b1w25ob5 3 12 - - SYM cord-006856-b1w25ob5 3 13 6 6 CD cord-006856-b1w25ob5 3 14 sha sha NN cord-006856-b1w25ob5 3 15 : : : cord-006856-b1w25ob5 4 1 b5bef1efd9dc0776fb890637a3f60deabee354da b5bef1efd9dc0776fb890637a3f60deabee354da VB cord-006856-b1w25ob5 4 2 doc_id doc_id CD cord-006856-b1w25ob5 4 3 : : : cord-006856-b1w25ob5 5 1 6856 6856 CD cord-006856-b1w25ob5 5 2 cord_uid cord_uid NNS cord-006856-b1w25ob5 5 3 : : : cord-006856-b1w25ob5 5 4 b1w25ob5 b1w25ob5 -LRB- cord-006856-b1w25ob5 5 5 nan nan NNP cord-006856-b1w25ob5 5 6 Background Background NNP cord-006856-b1w25ob5 5 7 . . . cord-006856-b1w25ob5 6 1 Nowadays nowadays RB cord-006856-b1w25ob5 6 2 lung lung NN cord-006856-b1w25ob5 6 3 transplantation transplantation NN cord-006856-b1w25ob5 6 4 is be VBZ cord-006856-b1w25ob5 6 5 an an DT cord-006856-b1w25ob5 6 6 established establish VBN cord-006856-b1w25ob5 6 7 standard standard JJ cord-006856-b1w25ob5 6 8 procedure procedure NN cord-006856-b1w25ob5 6 9 for for IN cord-006856-b1w25ob5 6 10 the the DT cord-006856-b1w25ob5 6 11 treatment treatment NN cord-006856-b1w25ob5 6 12 of of IN cord-006856-b1w25ob5 6 13 most most JJS cord-006856-b1w25ob5 6 14 end end NN cord-006856-b1w25ob5 6 15 - - HYPH cord-006856-b1w25ob5 6 16 stage stage NN cord-006856-b1w25ob5 6 17 respiratory respiratory JJ cord-006856-b1w25ob5 6 18 disorders disorder NNS cord-006856-b1w25ob5 6 19 . . . cord-006856-b1w25ob5 7 1 In in IN cord-006856-b1w25ob5 7 2 the the DT cord-006856-b1w25ob5 7 3 last last JJ cord-006856-b1w25ob5 7 4 years year NNS cord-006856-b1w25ob5 7 5 , , , cord-006856-b1w25ob5 7 6 like like IN cord-006856-b1w25ob5 7 7 for for IN cord-006856-b1w25ob5 7 8 all all DT cord-006856-b1w25ob5 7 9 solid solid JJ cord-006856-b1w25ob5 7 10 - - HYPH cord-006856-b1w25ob5 7 11 organ organ NN cord-006856-b1w25ob5 7 12 transplantations transplantation NNS cord-006856-b1w25ob5 7 13 , , , cord-006856-b1w25ob5 7 14 the the DT cord-006856-b1w25ob5 7 15 demand demand NN cord-006856-b1w25ob5 7 16 for for IN cord-006856-b1w25ob5 7 17 donor donor NN cord-006856-b1w25ob5 7 18 lungs lung NNS cord-006856-b1w25ob5 7 19 exceeded exceed VBD cord-006856-b1w25ob5 7 20 significantly significantly RB cord-006856-b1w25ob5 7 21 the the DT cord-006856-b1w25ob5 7 22 existing exist VBG cord-006856-b1w25ob5 7 23 organ organ NN cord-006856-b1w25ob5 7 24 pool pool NN cord-006856-b1w25ob5 7 25 . . . cord-006856-b1w25ob5 8 1 Thus thus RB cord-006856-b1w25ob5 8 2 , , , cord-006856-b1w25ob5 8 3 most most JJS cord-006856-b1w25ob5 8 4 specialised specialised JJ cord-006856-b1w25ob5 8 5 centers center NNS cord-006856-b1w25ob5 8 6 face face VBP cord-006856-b1w25ob5 8 7 a a DT cord-006856-b1w25ob5 8 8 high high JJ cord-006856-b1w25ob5 8 9 mortality mortality NN cord-006856-b1w25ob5 8 10 on on IN cord-006856-b1w25ob5 8 11 the the DT cord-006856-b1w25ob5 8 12 waiting waiting NN cord-006856-b1w25ob5 8 13 list list NN cord-006856-b1w25ob5 8 14 . . . cord-006856-b1w25ob5 9 1 This this DT cord-006856-b1w25ob5 9 2 retrospective retrospective JJ cord-006856-b1w25ob5 9 3 study study NN cord-006856-b1w25ob5 9 4 compares compare VBZ cord-006856-b1w25ob5 9 5 the the DT cord-006856-b1w25ob5 9 6 outcome outcome NN cord-006856-b1w25ob5 9 7 of of IN cord-006856-b1w25ob5 9 8 marginal marginal JJ cord-006856-b1w25ob5 9 9 versus versus IN cord-006856-b1w25ob5 9 10 ideal ideal JJ cord-006856-b1w25ob5 9 11 donor donor NN cord-006856-b1w25ob5 9 12 lungs lung NNS cord-006856-b1w25ob5 9 13 . . . cord-006856-b1w25ob5 10 1 Methods method NNS cord-006856-b1w25ob5 10 2 . . . cord-006856-b1w25ob5 11 1 We -PRON- PRP cord-006856-b1w25ob5 11 2 performed perform VBD cord-006856-b1w25ob5 11 3 a a DT cord-006856-b1w25ob5 11 4 retrospective retrospective JJ cord-006856-b1w25ob5 11 5 analysis analysis NN cord-006856-b1w25ob5 11 6 of of IN cord-006856-b1w25ob5 11 7 98 98 CD cord-006856-b1w25ob5 11 8 consecutive consecutive JJ cord-006856-b1w25ob5 11 9 primary primary JJ cord-006856-b1w25ob5 11 10 lung lung NN cord-006856-b1w25ob5 11 11 transplantations transplantation NNS cord-006856-b1w25ob5 11 12 from from IN cord-006856-b1w25ob5 11 13 94 94 CD cord-006856-b1w25ob5 11 14 donors donor NNS cord-006856-b1w25ob5 11 15 from from IN cord-006856-b1w25ob5 11 16 1/2001 1/2001 CD cord-006856-b1w25ob5 11 17 to to IN cord-006856-b1w25ob5 11 18 12/2002 12/2002 CD cord-006856-b1w25ob5 11 19 . . . cord-006856-b1w25ob5 12 1 Recipients recipient NNS cord-006856-b1w25ob5 12 2 were be VBD cord-006856-b1w25ob5 12 3 divided divide VBN cord-006856-b1w25ob5 12 4 in in IN cord-006856-b1w25ob5 12 5 two two CD cord-006856-b1w25ob5 12 6 groups group NNS cord-006856-b1w25ob5 12 7 ( ( -LRB- cord-006856-b1w25ob5 12 8 standard standard JJ cord-006856-b1w25ob5 12 9 versus versus IN cord-006856-b1w25ob5 12 10 " " `` cord-006856-b1w25ob5 12 11 extended extend VBN cord-006856-b1w25ob5 12 12 " " '' cord-006856-b1w25ob5 12 13 ) ) -RRB- cord-006856-b1w25ob5 12 14 according accord VBG cord-006856-b1w25ob5 12 15 to to IN cord-006856-b1w25ob5 12 16 the the DT cord-006856-b1w25ob5 12 17 donor donor NN cord-006856-b1w25ob5 12 18 lung lung NN cord-006856-b1w25ob5 12 19 acceptance acceptance NN cord-006856-b1w25ob5 12 20 criteria criterion NNS cord-006856-b1w25ob5 12 21 ( ( -LRB- cord-006856-b1w25ob5 12 22 age age NN cord-006856-b1w25ob5 12 23 , , , cord-006856-b1w25ob5 12 24 > > XX cord-006856-b1w25ob5 12 25 55 55 CD cord-006856-b1w25ob5 12 26 years year NNS cord-006856-b1w25ob5 12 27 ; ; : cord-006856-b1w25ob5 12 28 PaO pao NN cord-006856-b1w25ob5 12 29 2 2 CD cord-006856-b1w25ob5 12 30 at at IN cord-006856-b1w25ob5 12 31 FiO FiO NNP cord-006856-b1w25ob5 12 32 2 2 CD cord-006856-b1w25ob5 12 33 /PEEP /peep SYM cord-006856-b1w25ob5 12 34 5 5 CD cord-006856-b1w25ob5 12 35 , , , cord-006856-b1w25ob5 12 36 < < XX cord-006856-b1w25ob5 12 37 300 300 CD cord-006856-b1w25ob5 12 38 mmHg mmHg NNS cord-006856-b1w25ob5 12 39 ; ; , cord-006856-b1w25ob5 12 40 positive positive JJ cord-006856-b1w25ob5 12 41 tobacco tobacco NN cord-006856-b1w25ob5 12 42 anamnesis anamnesis NN cord-006856-b1w25ob5 12 43 [ [ -LRB- cord-006856-b1w25ob5 12 44 > > XX cord-006856-b1w25ob5 12 45 20 20 CD cord-006856-b1w25ob5 12 46 packages package NNS cord-006856-b1w25ob5 12 47 per per IN cord-006856-b1w25ob5 12 48 year year NN cord-006856-b1w25ob5 12 49 ] ] -RRB- cord-006856-b1w25ob5 12 50 ; ; : cord-006856-b1w25ob5 12 51 inhalation inhalation NN cord-006856-b1w25ob5 12 52 of of IN cord-006856-b1w25ob5 12 53 noxious noxious JJ cord-006856-b1w25ob5 12 54 agents agent NNS cord-006856-b1w25ob5 12 55 ; ; : cord-006856-b1w25ob5 12 56 presence presence NN cord-006856-b1w25ob5 12 57 of of IN cord-006856-b1w25ob5 12 58 infiltration infiltration NN cord-006856-b1w25ob5 12 59 on on IN cord-006856-b1w25ob5 12 60 chest chest NN cord-006856-b1w25ob5 12 61 X x NN cord-006856-b1w25ob5 12 62 - - NN cord-006856-b1w25ob5 12 63 ray ray NN cord-006856-b1w25ob5 12 64 or or CC cord-006856-b1w25ob5 12 65 purulent purulent JJ cord-006856-b1w25ob5 12 66 secretions secretion NNS cord-006856-b1w25ob5 12 67 at at IN cord-006856-b1w25ob5 12 68 bronchoscopy bronchoscopy NN cord-006856-b1w25ob5 12 69 ) ) -RRB- cord-006856-b1w25ob5 12 70 . . . cord-006856-b1w25ob5 13 1 Results result NNS cord-006856-b1w25ob5 13 2 . . . cord-006856-b1w25ob5 14 1 Twenty twenty CD cord-006856-b1w25ob5 14 2 - - HYPH cord-006856-b1w25ob5 14 3 three three CD cord-006856-b1w25ob5 14 4 donors donor NNS cord-006856-b1w25ob5 14 5 ( ( -LRB- cord-006856-b1w25ob5 14 6 24.5 24.5 CD cord-006856-b1w25ob5 14 7 % % NN cord-006856-b1w25ob5 14 8 ) ) -RRB- cord-006856-b1w25ob5 14 9 were be VBD cord-006856-b1w25ob5 14 10 extended extend VBN cord-006856-b1w25ob5 14 11 . . . cord-006856-b1w25ob5 15 1 Twenty twenty CD cord-006856-b1w25ob5 15 2 - - HYPH cord-006856-b1w25ob5 15 3 six six CD cord-006856-b1w25ob5 15 4 recipients recipient NNS cord-006856-b1w25ob5 15 5 ( ( -LRB- cord-006856-b1w25ob5 15 6 26.55 26.55 CD cord-006856-b1w25ob5 15 7 % % NN cord-006856-b1w25ob5 15 8 ) ) -RRB- cord-006856-b1w25ob5 15 9 received receive VBD cord-006856-b1w25ob5 15 10 organs organ NNS cord-006856-b1w25ob5 15 11 from from IN cord-006856-b1w25ob5 15 12 extended extended JJ cord-006856-b1w25ob5 15 13 donors donor NNS cord-006856-b1w25ob5 15 14 . . . cord-006856-b1w25ob5 16 1 According accord VBG cord-006856-b1w25ob5 16 2 to to IN cord-006856-b1w25ob5 16 3 our -PRON- PRP$ cord-006856-b1w25ob5 16 4 data datum NNS cord-006856-b1w25ob5 16 5 , , , cord-006856-b1w25ob5 16 6 differences difference NNS cord-006856-b1w25ob5 16 7 in in IN cord-006856-b1w25ob5 16 8 intubation intubation NN cord-006856-b1w25ob5 16 9 times time NNS cord-006856-b1w25ob5 16 10 , , , cord-006856-b1w25ob5 16 11 ICU ICU NNP cord-006856-b1w25ob5 16 12 stay stay VBP cord-006856-b1w25ob5 16 13 , , , cord-006856-b1w25ob5 16 14 and and CC cord-006856-b1w25ob5 16 15 hospital hospital NN cord-006856-b1w25ob5 16 16 stay stay NN cord-006856-b1w25ob5 16 17 were be VBD cord-006856-b1w25ob5 16 18 not not RB cord-006856-b1w25ob5 16 19 statistically statistically RB cord-006856-b1w25ob5 16 20 significant significant JJ cord-006856-b1w25ob5 16 21 . . . cord-006856-b1w25ob5 17 1 Furthermore furthermore RB cord-006856-b1w25ob5 17 2 , , , cord-006856-b1w25ob5 17 3 postoperative postoperative JJ cord-006856-b1w25ob5 17 4 bleeding bleeding NN cord-006856-b1w25ob5 17 5 rates rate NNS cord-006856-b1w25ob5 17 6 were be VBD cord-006856-b1w25ob5 17 7 comparable comparable JJ cord-006856-b1w25ob5 17 8 as as RB cord-006856-b1w25ob5 17 9 well well RB cord-006856-b1w25ob5 17 10 as as IN cord-006856-b1w25ob5 17 11 bronchial bronchial JJ cord-006856-b1w25ob5 17 12 anastomotic anastomotic JJ cord-006856-b1w25ob5 17 13 complications complication NNS cord-006856-b1w25ob5 17 14 . . . cord-006856-b1w25ob5 18 1 We -PRON- PRP cord-006856-b1w25ob5 18 2 encountered encounter VBD cord-006856-b1w25ob5 18 3 no no DT cord-006856-b1w25ob5 18 4 significant significant JJ cord-006856-b1w25ob5 18 5 statistical statistical JJ cord-006856-b1w25ob5 18 6 difference difference NN cord-006856-b1w25ob5 18 7 in in IN cord-006856-b1w25ob5 18 8 the the DT cord-006856-b1w25ob5 18 9 3-month 3-month CD cord-006856-b1w25ob5 18 10 ( ( -LRB- cord-006856-b1w25ob5 18 11 standard standard JJ cord-006856-b1w25ob5 18 12 88.89 88.89 CD cord-006856-b1w25ob5 18 13 % % NN cord-006856-b1w25ob5 18 14 vs. vs. FW cord-006856-b1w25ob5 18 15 extended extended JJ cord-006856-b1w25ob5 18 16 92.31 92.31 CD cord-006856-b1w25ob5 18 17 % % NN cord-006856-b1w25ob5 18 18 ) ) -RRB- cord-006856-b1w25ob5 18 19 and and CC cord-006856-b1w25ob5 18 20 1-year 1-year CD cord-006856-b1w25ob5 18 21 ( ( -LRB- cord-006856-b1w25ob5 18 22 standard standard JJ cord-006856-b1w25ob5 18 23 81.94 81.94 CD cord-006856-b1w25ob5 18 24 % % NN cord-006856-b1w25ob5 18 25 vs. vs. CC cord-006856-b1w25ob5 18 26 extended extend VBN cord-006856-b1w25ob5 18 27 84.62 84.62 CD cord-006856-b1w25ob5 18 28 % % NN cord-006856-b1w25ob5 18 29 ) ) -RRB- cord-006856-b1w25ob5 18 30 survival survival NN cord-006856-b1w25ob5 18 31 between between IN cord-006856-b1w25ob5 18 32 the the DT cord-006856-b1w25ob5 18 33 two two CD cord-006856-b1w25ob5 18 34 groups group NNS cord-006856-b1w25ob5 18 35 . . . cord-006856-b1w25ob5 19 1 Conclusions conclusion NNS cord-006856-b1w25ob5 19 2 . . . cord-006856-b1w25ob5 20 1 Our -PRON- PRP$ cord-006856-b1w25ob5 20 2 study study NN cord-006856-b1w25ob5 20 3 suggests suggest VBZ cord-006856-b1w25ob5 20 4 that that IN cord-006856-b1w25ob5 20 5 the the DT cord-006856-b1w25ob5 20 6 use use NN cord-006856-b1w25ob5 20 7 of of IN cord-006856-b1w25ob5 20 8 selected select VBN cord-006856-b1w25ob5 20 9 marginal marginal JJ cord-006856-b1w25ob5 20 10 donor donor NN cord-006856-b1w25ob5 20 11 lungs lung NNS cord-006856-b1w25ob5 20 12 has have VBZ cord-006856-b1w25ob5 20 13 no no DT cord-006856-b1w25ob5 20 14 influence influence NN cord-006856-b1w25ob5 20 15 on on IN cord-006856-b1w25ob5 20 16 the the DT cord-006856-b1w25ob5 20 17 outcome outcome NN cord-006856-b1w25ob5 20 18 after after IN cord-006856-b1w25ob5 20 19 transplantation transplantation NN cord-006856-b1w25ob5 20 20 . . . cord-006856-b1w25ob5 21 1 Background background NN cord-006856-b1w25ob5 21 2 . . . cord-006856-b1w25ob5 22 1 Female female JJ cord-006856-b1w25ob5 22 2 donor donor NN cord-006856-b1w25ob5 22 3 gender gender NN cord-006856-b1w25ob5 22 4 has have VBZ cord-006856-b1w25ob5 22 5 been be VBN cord-006856-b1w25ob5 22 6 described describe VBN cord-006856-b1w25ob5 22 7 to to TO cord-006856-b1w25ob5 22 8 be be VB cord-006856-b1w25ob5 22 9 an an DT cord-006856-b1w25ob5 22 10 independent independent JJ cord-006856-b1w25ob5 22 11 risk risk NN cord-006856-b1w25ob5 22 12 factor factor NN cord-006856-b1w25ob5 22 13 for for IN cord-006856-b1w25ob5 22 14 primary primary JJ cord-006856-b1w25ob5 22 15 graft graft NN cord-006856-b1w25ob5 22 16 failure failure NN cord-006856-b1w25ob5 22 17 . . . cord-006856-b1w25ob5 23 1 We -PRON- PRP cord-006856-b1w25ob5 23 2 performed perform VBD cord-006856-b1w25ob5 23 3 this this DT cord-006856-b1w25ob5 23 4 study study NN cord-006856-b1w25ob5 23 5 to to TO cord-006856-b1w25ob5 23 6 evaluate evaluate VB cord-006856-b1w25ob5 23 7 the the DT cord-006856-b1w25ob5 23 8 impact impact NN cord-006856-b1w25ob5 23 9 of of IN cord-006856-b1w25ob5 23 10 donor donor NN cord-006856-b1w25ob5 23 11 gender gender NN cord-006856-b1w25ob5 23 12 on on IN cord-006856-b1w25ob5 23 13 outcome outcome NN cord-006856-b1w25ob5 23 14 and and CC cord-006856-b1w25ob5 23 15 complications complication NNS cord-006856-b1w25ob5 23 16 after after IN cord-006856-b1w25ob5 23 17 lung lung NN cord-006856-b1w25ob5 23 18 transplantation transplantation NN cord-006856-b1w25ob5 23 19 . . . cord-006856-b1w25ob5 24 1 Methods method NNS cord-006856-b1w25ob5 24 2 . . . cord-006856-b1w25ob5 25 1 We -PRON- PRP cord-006856-b1w25ob5 25 2 retrospectively retrospectively RB cord-006856-b1w25ob5 25 3 reviewed review VBD cord-006856-b1w25ob5 25 4 the the DT cord-006856-b1w25ob5 25 5 impact impact NN cord-006856-b1w25ob5 25 6 of of IN cord-006856-b1w25ob5 25 7 donor donor NN cord-006856-b1w25ob5 25 8 gender gender NN cord-006856-b1w25ob5 25 9 on on IN cord-006856-b1w25ob5 25 10 outcome outcome NN cord-006856-b1w25ob5 25 11 of of IN cord-006856-b1w25ob5 25 12 163 163 CD cord-006856-b1w25ob5 25 13 primary primary JJ cord-006856-b1w25ob5 25 14 lung lung NN cord-006856-b1w25ob5 25 15 transplant transplant NN cord-006856-b1w25ob5 25 16 recipients recipient NNS cord-006856-b1w25ob5 25 17 ( ( -LRB- cord-006856-b1w25ob5 25 18 93 93 CD cord-006856-b1w25ob5 25 19 recipients recipient NNS cord-006856-b1w25ob5 25 20 were be VBD cord-006856-b1w25ob5 25 21 male male JJ cord-006856-b1w25ob5 25 22 [ [ -LRB- cord-006856-b1w25ob5 25 23 57 57 CD cord-006856-b1w25ob5 25 24 % % NN cord-006856-b1w25ob5 25 25 ] ] -RRB- cord-006856-b1w25ob5 25 26 , , , cord-006856-b1w25ob5 25 27 70 70 CD cord-006856-b1w25ob5 25 28 were be VBD cord-006856-b1w25ob5 25 29 female female JJ cord-006856-b1w25ob5 25 30 [ [ -LRB- cord-006856-b1w25ob5 25 31 43 43 CD cord-006856-b1w25ob5 25 32 % % NN cord-006856-b1w25ob5 25 33 ] ] -RRB- cord-006856-b1w25ob5 25 34 ) ) -RRB- cord-006856-b1w25ob5 25 35 from from IN cord-006856-b1w25ob5 25 36 January January NNP cord-006856-b1w25ob5 25 37 2001 2001 CD cord-006856-b1w25ob5 25 38 to to IN cord-006856-b1w25ob5 25 39 December December NNP cord-006856-b1w25ob5 25 40 2003 2003 CD cord-006856-b1w25ob5 25 41 . . . cord-006856-b1w25ob5 26 1 Recipients recipient NNS cord-006856-b1w25ob5 26 2 were be VBD cord-006856-b1w25ob5 26 3 stratified stratified JJ cord-006856-b1w25ob5 26 4 whether whether IN cord-006856-b1w25ob5 26 5 they -PRON- PRP cord-006856-b1w25ob5 26 6 received receive VBD cord-006856-b1w25ob5 26 7 a a DT cord-006856-b1w25ob5 26 8 female female NN cord-006856-b1w25ob5 26 9 - - HYPH cord-006856-b1w25ob5 26 10 or or CC cord-006856-b1w25ob5 26 11 male male JJ cord-006856-b1w25ob5 26 12 - - HYPH cord-006856-b1w25ob5 26 13 donor donor NN cord-006856-b1w25ob5 26 14 organ organ NN cord-006856-b1w25ob5 26 15 . . . cord-006856-b1w25ob5 27 1 Both both DT cord-006856-b1w25ob5 27 2 groups group NNS cord-006856-b1w25ob5 27 3 were be VBD cord-006856-b1w25ob5 27 4 compared compare VBN cord-006856-b1w25ob5 27 5 with with IN cord-006856-b1w25ob5 27 6 regard regard NN cord-006856-b1w25ob5 27 7 to to IN cord-006856-b1w25ob5 27 8 duration duration NN cord-006856-b1w25ob5 27 9 of of IN cord-006856-b1w25ob5 27 10 intubation intubation NN cord-006856-b1w25ob5 27 11 time time NN cord-006856-b1w25ob5 27 12 , , , cord-006856-b1w25ob5 27 13 ICU ICU NNP cord-006856-b1w25ob5 27 14 stay stay VBP cord-006856-b1w25ob5 27 15 , , , cord-006856-b1w25ob5 27 16 postoperative postoperative JJ cord-006856-b1w25ob5 27 17 complications complication NNS cord-006856-b1w25ob5 27 18 and and CC cord-006856-b1w25ob5 27 19 survival survival NN cord-006856-b1w25ob5 27 20 . . . cord-006856-b1w25ob5 28 1 Both both DT cord-006856-b1w25ob5 28 2 groups group NNS cord-006856-b1w25ob5 28 3 were be VBD cord-006856-b1w25ob5 28 4 comparable comparable JJ cord-006856-b1w25ob5 28 5 with with IN cord-006856-b1w25ob5 28 6 regard regard NN cord-006856-b1w25ob5 28 7 to to TO cord-006856-b1w25ob5 28 8 mean mean VB cord-006856-b1w25ob5 28 9 age age NN cord-006856-b1w25ob5 28 10 , , , cord-006856-b1w25ob5 28 11 indications indication NNS cord-006856-b1w25ob5 28 12 , , , cord-006856-b1w25ob5 28 13 and and CC cord-006856-b1w25ob5 29 1 mean mean VB cord-006856-b1w25ob5 29 2 waiting wait VBG cord-006856-b1w25ob5 29 3 list list NN cord-006856-b1w25ob5 29 4 time time NN cord-006856-b1w25ob5 29 5 . . . cord-006856-b1w25ob5 30 1 Results result NNS cord-006856-b1w25ob5 30 2 . . . cord-006856-b1w25ob5 31 1 Mean mean JJ cord-006856-b1w25ob5 31 2 time time NN cord-006856-b1w25ob5 31 3 until until IN cord-006856-b1w25ob5 31 4 extubation extubation NN cord-006856-b1w25ob5 31 5 was be VBD cord-006856-b1w25ob5 31 6 8 8 CD cord-006856-b1w25ob5 31 7 days day NNS cord-006856-b1w25ob5 31 8 in in IN cord-006856-b1w25ob5 31 9 the the DT cord-006856-b1w25ob5 31 10 group group NN cord-006856-b1w25ob5 31 11 receiving receive VBG cord-006856-b1w25ob5 31 12 organs organ NNS cord-006856-b1w25ob5 31 13 from from IN cord-006856-b1w25ob5 31 14 male male JJ cord-006856-b1w25ob5 31 15 donors donor NNS cord-006856-b1w25ob5 31 16 and and CC cord-006856-b1w25ob5 31 17 16 16 CD cord-006856-b1w25ob5 31 18 days day NNS cord-006856-b1w25ob5 31 19 in in IN cord-006856-b1w25ob5 31 20 the the DT cord-006856-b1w25ob5 31 21 group group NN cord-006856-b1w25ob5 31 22 receiving receive VBG cord-006856-b1w25ob5 31 23 organs organ NNS cord-006856-b1w25ob5 31 24 from from IN cord-006856-b1w25ob5 31 25 female female JJ cord-006856-b1w25ob5 31 26 donors donor NNS cord-006856-b1w25ob5 31 27 ( ( -LRB- cord-006856-b1w25ob5 31 28 P p NN cord-006856-b1w25ob5 31 29 = = SYM cord-006856-b1w25ob5 31 30 0.041 0.041 CD cord-006856-b1w25ob5 31 31 ) ) -RRB- cord-006856-b1w25ob5 31 32 . . . cord-006856-b1w25ob5 32 1 Mean mean JJ cord-006856-b1w25ob5 32 2 ICU ICU NNP cord-006856-b1w25ob5 32 3 stay stay NN cord-006856-b1w25ob5 32 4 of of IN cord-006856-b1w25ob5 32 5 12 12 CD cord-006856-b1w25ob5 32 6 days day NNS cord-006856-b1w25ob5 32 7 for for IN cord-006856-b1w25ob5 32 8 the the DT cord-006856-b1w25ob5 32 9 male male JJ cord-006856-b1w25ob5 32 10 - - HYPH cord-006856-b1w25ob5 32 11 donor donor NN cord-006856-b1w25ob5 32 12 recipient recipient NN cord-006856-b1w25ob5 32 13 group group NN cord-006856-b1w25ob5 32 14 was be VBD cord-006856-b1w25ob5 32 15 significantly significantly RB cord-006856-b1w25ob5 32 16 shorter short JJR cord-006856-b1w25ob5 32 17 than than IN cord-006856-b1w25ob5 32 18 that that DT cord-006856-b1w25ob5 32 19 for for IN cord-006856-b1w25ob5 32 20 the the DT cord-006856-b1w25ob5 32 21 female female JJ cord-006856-b1w25ob5 32 22 - - HYPH cord-006856-b1w25ob5 32 23 donor donor NN cord-006856-b1w25ob5 32 24 recipient recipient NN cord-006856-b1w25ob5 32 25 group group NN cord-006856-b1w25ob5 32 26 , , , cord-006856-b1w25ob5 32 27 20 20 CD cord-006856-b1w25ob5 32 28 days day NNS cord-006856-b1w25ob5 32 29 ( ( -LRB- cord-006856-b1w25ob5 32 30 P p NN cord-006856-b1w25ob5 32 31 = = SYM cord-006856-b1w25ob5 32 32 0.044 0.044 CD cord-006856-b1w25ob5 32 33 ) ) -RRB- cord-006856-b1w25ob5 32 34 . . . cord-006856-b1w25ob5 33 1 3-month 3-month CD cord-006856-b1w25ob5 33 2 survival survival NN cord-006856-b1w25ob5 33 3 rates rate NNS cord-006856-b1w25ob5 33 4 were be VBD cord-006856-b1w25ob5 33 5 comparable comparable JJ cord-006856-b1w25ob5 33 6 in in IN cord-006856-b1w25ob5 33 7 both both DT cord-006856-b1w25ob5 33 8 groups group NNS cord-006856-b1w25ob5 33 9 : : : cord-006856-b1w25ob5 33 10 89.53 89.53 CD cord-006856-b1w25ob5 33 11 % % NN cord-006856-b1w25ob5 33 12 ( ( -LRB- cord-006856-b1w25ob5 33 13 male male JJ cord-006856-b1w25ob5 33 14 - - HYPH cord-006856-b1w25ob5 33 15 donor donor NN cord-006856-b1w25ob5 33 16 recipi recipi NN cord-006856-b1w25ob5 33 17 - - HYPH cord-006856-b1w25ob5 33 18 Lunge Lunge NNP cord-006856-b1w25ob5 33 19 19th 19th NN cord-006856-b1w25ob5 33 20 Meeting Meeting NNP cord-006856-b1w25ob5 33 21 of of IN cord-006856-b1w25ob5 33 22 the the DT cord-006856-b1w25ob5 33 23 Austrian Austrian NNP cord-006856-b1w25ob5 33 24 Society Society NNP cord-006856-b1w25ob5 33 25 of of IN cord-006856-b1w25ob5 33 26 Transplantation Transplantation NNP cord-006856-b1w25ob5 33 27 , , , cord-006856-b1w25ob5 33 28 Transfusion Transfusion NNP cord-006856-b1w25ob5 33 29 and and CC cord-006856-b1w25ob5 33 30 Genetics Genetics NNP cord-006856-b1w25ob5 33 31 Background Background NNP cord-006856-b1w25ob5 33 32 . . . cord-006856-b1w25ob5 34 1 Nowadays nowadays RB cord-006856-b1w25ob5 34 2 lung lung NN cord-006856-b1w25ob5 34 3 transplantation transplantation NN cord-006856-b1w25ob5 34 4 is be VBZ cord-006856-b1w25ob5 34 5 an an DT cord-006856-b1w25ob5 34 6 established establish VBN cord-006856-b1w25ob5 34 7 therapeutic therapeutic JJ cord-006856-b1w25ob5 34 8 option option NN cord-006856-b1w25ob5 34 9 for for IN cord-006856-b1w25ob5 34 10 most most JJS cord-006856-b1w25ob5 34 11 end end NN cord-006856-b1w25ob5 34 12 - - HYPH cord-006856-b1w25ob5 34 13 stage stage NN cord-006856-b1w25ob5 34 14 respiratory respiratory JJ cord-006856-b1w25ob5 34 15 diseases disease NNS cord-006856-b1w25ob5 34 16 and and CC cord-006856-b1w25ob5 34 17 one one CD cord-006856-b1w25ob5 34 18 of of IN cord-006856-b1w25ob5 34 19 the the DT cord-006856-b1w25ob5 34 20 fastest fast RBS cord-006856-b1w25ob5 34 21 - - HYPH cord-006856-b1w25ob5 34 22 growing grow VBG cord-006856-b1w25ob5 34 23 solid solid JJ cord-006856-b1w25ob5 34 24 - - HYPH cord-006856-b1w25ob5 34 25 organ organ NN cord-006856-b1w25ob5 34 26 transplantation transplantation NN cord-006856-b1w25ob5 34 27 procedures procedure NNS cord-006856-b1w25ob5 34 28 in in IN cord-006856-b1w25ob5 34 29 the the DT cord-006856-b1w25ob5 34 30 world world NN cord-006856-b1w25ob5 34 31 , , , cord-006856-b1w25ob5 34 32 reflected reflect VBN cord-006856-b1w25ob5 34 33 by by IN cord-006856-b1w25ob5 34 34 the the DT cord-006856-b1w25ob5 34 35 enormous enormous JJ cord-006856-b1w25ob5 34 36 demand demand NN cord-006856-b1w25ob5 34 37 for for IN cord-006856-b1w25ob5 34 38 lungs lung NNS cord-006856-b1w25ob5 34 39 . . . cord-006856-b1w25ob5 35 1 This this DT cord-006856-b1w25ob5 35 2 retrospective retrospective JJ cord-006856-b1w25ob5 35 3 review review NN cord-006856-b1w25ob5 35 4 of of IN cord-006856-b1w25ob5 35 5 the the DT cord-006856-b1w25ob5 35 6 Vienna Vienna NNP cord-006856-b1w25ob5 35 7 lung lung NN cord-006856-b1w25ob5 35 8 transplantation transplantation NN cord-006856-b1w25ob5 35 9 group group NN cord-006856-b1w25ob5 35 10 demonstrates demonstrate VBZ cord-006856-b1w25ob5 35 11 data datum NNS cord-006856-b1w25ob5 35 12 about about IN cord-006856-b1w25ob5 35 13 waiting wait VBG cord-006856-b1w25ob5 35 14 time time NN cord-006856-b1w25ob5 35 15 and and CC cord-006856-b1w25ob5 35 16 mortality mortality NN cord-006856-b1w25ob5 35 17 rate rate NN cord-006856-b1w25ob5 35 18 for for IN cord-006856-b1w25ob5 35 19 various various JJ cord-006856-b1w25ob5 35 20 end end NN cord-006856-b1w25ob5 35 21 - - HYPH cord-006856-b1w25ob5 35 22 stage stage NN cord-006856-b1w25ob5 35 23 respiratory respiratory JJ cord-006856-b1w25ob5 35 24 diseases disease NNS cord-006856-b1w25ob5 35 25 for for IN cord-006856-b1w25ob5 35 26 the the DT cord-006856-b1w25ob5 35 27 years year NNS cord-006856-b1w25ob5 35 28 2003 2003 CD cord-006856-b1w25ob5 35 29 and and CC cord-006856-b1w25ob5 35 30 2004 2004 CD cord-006856-b1w25ob5 35 31 . . . cord-006856-b1w25ob5 36 1 Methods method NNS cord-006856-b1w25ob5 36 2 . . . cord-006856-b1w25ob5 36 3 . . . cord-006856-b1w25ob5 37 1 Different different JJ cord-006856-b1w25ob5 37 2 variables variable NNS cord-006856-b1w25ob5 37 3 specific specific JJ cord-006856-b1w25ob5 37 4 for for IN cord-006856-b1w25ob5 37 5 pretransplant pretransplant JJ cord-006856-b1w25ob5 37 6 period period NN cord-006856-b1w25ob5 37 7 such such JJ cord-006856-b1w25ob5 37 8 as as IN cord-006856-b1w25ob5 37 9 probability probability NN cord-006856-b1w25ob5 37 10 of of IN cord-006856-b1w25ob5 37 11 transplantation transplantation NN cord-006856-b1w25ob5 37 12 , , , cord-006856-b1w25ob5 37 13 death death NN cord-006856-b1w25ob5 37 14 on on IN cord-006856-b1w25ob5 37 15 the the DT cord-006856-b1w25ob5 37 16 waiting waiting NN cord-006856-b1w25ob5 37 17 list list NN cord-006856-b1w25ob5 37 18 , , , cord-006856-b1w25ob5 37 19 and and CC cord-006856-b1w25ob5 37 20 time time NN cord-006856-b1w25ob5 37 21 till till IN cord-006856-b1w25ob5 37 22 transplantation transplantation NN cord-006856-b1w25ob5 37 23 were be VBD cord-006856-b1w25ob5 37 24 analysed analyse VBN cord-006856-b1w25ob5 37 25 for for IN cord-006856-b1w25ob5 37 26 most most RBS cord-006856-b1w25ob5 37 27 frequent frequent JJ cord-006856-b1w25ob5 37 28 end end NN cord-006856-b1w25ob5 37 29 - - HYPH cord-006856-b1w25ob5 37 30 stage stage NN cord-006856-b1w25ob5 37 31 respiratory respiratory JJ cord-006856-b1w25ob5 37 32 diseases disease NNS cord-006856-b1w25ob5 37 33 . . . cord-006856-b1w25ob5 38 1 Results result NNS cord-006856-b1w25ob5 38 2 . . . cord-006856-b1w25ob5 39 1 We -PRON- PRP cord-006856-b1w25ob5 39 2 found find VBD cord-006856-b1w25ob5 39 3 no no DT cord-006856-b1w25ob5 39 4 significant significant JJ cord-006856-b1w25ob5 39 5 changes change NNS cord-006856-b1w25ob5 39 6 in in IN cord-006856-b1w25ob5 39 7 the the DT cord-006856-b1w25ob5 39 8 average average JJ cord-006856-b1w25ob5 39 9 mortality mortality NN cord-006856-b1w25ob5 39 10 rate rate NN cord-006856-b1w25ob5 39 11 ( ( -LRB- cord-006856-b1w25ob5 39 12 constantly constantly RB cord-006856-b1w25ob5 39 13 8 8 CD cord-006856-b1w25ob5 39 14 % % NN cord-006856-b1w25ob5 39 15 ) ) -RRB- cord-006856-b1w25ob5 39 16 on on IN cord-006856-b1w25ob5 39 17 the the DT cord-006856-b1w25ob5 39 18 waiting waiting NN cord-006856-b1w25ob5 39 19 list list NN cord-006856-b1w25ob5 39 20 during during IN cord-006856-b1w25ob5 39 21 the the DT cord-006856-b1w25ob5 39 22 studied study VBN cord-006856-b1w25ob5 39 23 period period NN cord-006856-b1w25ob5 39 24 . . . cord-006856-b1w25ob5 40 1 However however RB cord-006856-b1w25ob5 40 2 , , , cord-006856-b1w25ob5 40 3 patients patient NNS cord-006856-b1w25ob5 40 4 suffering suffer VBG cord-006856-b1w25ob5 40 5 from from IN cord-006856-b1w25ob5 40 6 PPH pph NN cord-006856-b1w25ob5 40 7 have have VBP cord-006856-b1w25ob5 40 8 the the DT cord-006856-b1w25ob5 40 9 highest high JJS cord-006856-b1w25ob5 40 10 probability probability NN cord-006856-b1w25ob5 40 11 of of IN cord-006856-b1w25ob5 40 12 dying die VBG cord-006856-b1w25ob5 40 13 while while IN cord-006856-b1w25ob5 40 14 being be VBG cord-006856-b1w25ob5 40 15 listed list VBN cord-006856-b1w25ob5 40 16 for for IN cord-006856-b1w25ob5 40 17 lung lung NN cord-006856-b1w25ob5 40 18 transplantation transplantation NN cord-006856-b1w25ob5 40 19 ( ( -LRB- cord-006856-b1w25ob5 40 20 2003 2003 CD cord-006856-b1w25ob5 40 21 , , , cord-006856-b1w25ob5 40 22 n n NN cord-006856-b1w25ob5 40 23 = = SYM cord-006856-b1w25ob5 40 24 2 2 CD cord-006856-b1w25ob5 40 25 [ [ -LRB- cord-006856-b1w25ob5 40 26 20 20 CD cord-006856-b1w25ob5 40 27 % % NN cord-006856-b1w25ob5 40 28 ] ] -RRB- cord-006856-b1w25ob5 40 29 ; ; : cord-006856-b1w25ob5 40 30 2004 2004 CD cord-006856-b1w25ob5 40 31 , , , cord-006856-b1w25ob5 40 32 n n NN cord-006856-b1w25ob5 40 33 = = SYM cord-006856-b1w25ob5 40 34 2 2 CD cord-006856-b1w25ob5 40 35 [ [ -LRB- cord-006856-b1w25ob5 40 36 14.3 14.3 CD cord-006856-b1w25ob5 40 37 % % NN cord-006856-b1w25ob5 40 38 ] ] -RRB- cord-006856-b1w25ob5 40 39 ) ) -RRB- cord-006856-b1w25ob5 40 40 , , , cord-006856-b1w25ob5 40 41 followed follow VBN cord-006856-b1w25ob5 40 42 by by IN cord-006856-b1w25ob5 40 43 patients patient NNS cord-006856-b1w25ob5 40 44 with with IN cord-006856-b1w25ob5 40 45 idiopathic idiopathic JJ cord-006856-b1w25ob5 40 46 fibrosis fibrosis NN cord-006856-b1w25ob5 40 47 ( ( -LRB- cord-006856-b1w25ob5 40 48 2003 2003 CD cord-006856-b1w25ob5 40 49 , , , cord-006856-b1w25ob5 40 50 n n NN cord-006856-b1w25ob5 40 51 = = SYM cord-006856-b1w25ob5 40 52 3 3 CD cord-006856-b1w25ob5 40 53 [ [ -LRB- cord-006856-b1w25ob5 40 54 15 15 CD cord-006856-b1w25ob5 40 55 % % NN cord-006856-b1w25ob5 40 56 ] ] -RRB- cord-006856-b1w25ob5 40 57 ; ; : cord-006856-b1w25ob5 40 58 2004 2004 CD cord-006856-b1w25ob5 40 59 , , , cord-006856-b1w25ob5 40 60 n n NN cord-006856-b1w25ob5 40 61 = = SYM cord-006856-b1w25ob5 40 62 4 4 CD cord-006856-b1w25ob5 40 63 [ [ -LRB- cord-006856-b1w25ob5 40 64 11.4 11.4 CD cord-006856-b1w25ob5 40 65 % % NN cord-006856-b1w25ob5 40 66 ] ] -RRB- cord-006856-b1w25ob5 40 67 ) ) -RRB- cord-006856-b1w25ob5 40 68 . . . cord-006856-b1w25ob5 41 1 Subsequently subsequently RB cord-006856-b1w25ob5 41 2 the the DT cord-006856-b1w25ob5 41 3 next next JJ cord-006856-b1w25ob5 41 4 subgroup subgroup NN cord-006856-b1w25ob5 41 5 is be VBZ cord-006856-b1w25ob5 41 6 represented represent VBN cord-006856-b1w25ob5 41 7 by by IN cord-006856-b1w25ob5 41 8 cystic cystic JJ cord-006856-b1w25ob5 41 9 fibrosis fibrosis NN cord-006856-b1w25ob5 41 10 patients patient NNS cord-006856-b1w25ob5 41 11 , , , cord-006856-b1w25ob5 41 12 who who WP cord-006856-b1w25ob5 41 13 are be VBP cord-006856-b1w25ob5 41 14 characterized characterize VBN cord-006856-b1w25ob5 41 15 by by IN cord-006856-b1w25ob5 41 16 a a DT cord-006856-b1w25ob5 41 17 moderate moderate JJ cord-006856-b1w25ob5 41 18 mortality mortality NN cord-006856-b1w25ob5 41 19 rate rate NN cord-006856-b1w25ob5 41 20 ( ( -LRB- cord-006856-b1w25ob5 41 21 2003 2003 CD cord-006856-b1w25ob5 41 22 , , , cord-006856-b1w25ob5 41 23 n n NN cord-006856-b1w25ob5 41 24 = = SYM cord-006856-b1w25ob5 41 25 1 1 CD cord-006856-b1w25ob5 41 26 [ [ -LRB- cord-006856-b1w25ob5 41 27 3.8 3.8 CD cord-006856-b1w25ob5 41 28 % % NN cord-006856-b1w25ob5 41 29 ] ] -RRB- cord-006856-b1w25ob5 41 30 ; ; : cord-006856-b1w25ob5 41 31 2004 2004 CD cord-006856-b1w25ob5 41 32 , , , cord-006856-b1w25ob5 41 33 n n NN cord-006856-b1w25ob5 41 34 = = SYM cord-006856-b1w25ob5 41 35 1 1 CD cord-006856-b1w25ob5 41 36 [ [ -LRB- cord-006856-b1w25ob5 41 37 5 5 CD cord-006856-b1w25ob5 41 38 % % NN cord-006856-b1w25ob5 41 39 ] ] -RRB- cord-006856-b1w25ob5 41 40 ) ) -RRB- cord-006856-b1w25ob5 41 41 . . . cord-006856-b1w25ob5 42 1 In in IN cord-006856-b1w25ob5 42 2 contrast contrast NN cord-006856-b1w25ob5 42 3 , , , cord-006856-b1w25ob5 42 4 patients patient NNS cord-006856-b1w25ob5 42 5 who who WP cord-006856-b1w25ob5 42 6 were be VBD cord-006856-b1w25ob5 42 7 suffering suffer VBG cord-006856-b1w25ob5 42 8 from from IN cord-006856-b1w25ob5 42 9 COPD COPD NNP cord-006856-b1w25ob5 42 10 showed show VBD cord-006856-b1w25ob5 42 11 the the DT cord-006856-b1w25ob5 42 12 lowest low JJS cord-006856-b1w25ob5 42 13 probability probability NN cord-006856-b1w25ob5 42 14 of of IN cord-006856-b1w25ob5 42 15 dying die VBG cord-006856-b1w25ob5 42 16 ( ( -LRB- cord-006856-b1w25ob5 42 17 2003 2003 CD cord-006856-b1w25ob5 42 18 , , , cord-006856-b1w25ob5 42 19 n n NN cord-006856-b1w25ob5 42 20 = = SYM cord-006856-b1w25ob5 42 21 0 0 NFP cord-006856-b1w25ob5 42 22 [ [ -LRB- cord-006856-b1w25ob5 42 23 0 0 CD cord-006856-b1w25ob5 42 24 % % NN cord-006856-b1w25ob5 42 25 ] ] -RRB- cord-006856-b1w25ob5 42 26 ; ; : cord-006856-b1w25ob5 42 27 2004 2004 CD cord-006856-b1w25ob5 42 28 , , , cord-006856-b1w25ob5 42 29 n n NN cord-006856-b1w25ob5 42 30 = = SYM cord-006856-b1w25ob5 42 31 1 1 CD cord-006856-b1w25ob5 42 32 [ [ -LRB- cord-006856-b1w25ob5 42 33 2.9 2.9 CD cord-006856-b1w25ob5 42 34 % % NN cord-006856-b1w25ob5 42 35 ] ] -RRB- cord-006856-b1w25ob5 42 36 ) ) -RRB- cord-006856-b1w25ob5 42 37 . . . cord-006856-b1w25ob5 43 1 The the DT cord-006856-b1w25ob5 43 2 average average JJ cord-006856-b1w25ob5 43 3 waiting wait VBG cord-006856-b1w25ob5 43 4 time time NN cord-006856-b1w25ob5 43 5 for for IN cord-006856-b1w25ob5 43 6 the the DT cord-006856-b1w25ob5 43 7 observed observed JJ cord-006856-b1w25ob5 43 8 2 2 CD cord-006856-b1w25ob5 43 9 years year NNS cord-006856-b1w25ob5 43 10 amounts amount VBZ cord-006856-b1w25ob5 43 11 to to IN cord-006856-b1w25ob5 43 12 97.5 97.5 CD cord-006856-b1w25ob5 43 13 days day NNS cord-006856-b1w25ob5 43 14 ( ( -LRB- cord-006856-b1w25ob5 43 15 2003 2003 CD cord-006856-b1w25ob5 43 16 , , , cord-006856-b1w25ob5 43 17 99 99 CD cord-006856-b1w25ob5 43 18 ± ± CD cord-006856-b1w25ob5 43 19 98 98 CD cord-006856-b1w25ob5 43 20 [ [ -LRB- cord-006856-b1w25ob5 43 21 min min NN cord-006856-b1w25ob5 43 22 , , , cord-006856-b1w25ob5 43 23 0 0 CD cord-006856-b1w25ob5 44 1 ; ; : cord-006856-b1w25ob5 44 2 max max NNP cord-006856-b1w25ob5 44 3 , , , cord-006856-b1w25ob5 44 4 464 464 CD cord-006856-b1w25ob5 44 5 ] ] -RRB- cord-006856-b1w25ob5 44 6 days day NNS cord-006856-b1w25ob5 44 7 ; ; : cord-006856-b1w25ob5 44 8 2004 2004 CD cord-006856-b1w25ob5 44 9 , , , cord-006856-b1w25ob5 44 10 96 96 CD cord-006856-b1w25ob5 44 11 ± ± CD cord-006856-b1w25ob5 44 12 96 96 CD cord-006856-b1w25ob5 44 13 [ [ -LRB- cord-006856-b1w25ob5 44 14 min min NN cord-006856-b1w25ob5 44 15 , , , cord-006856-b1w25ob5 44 16 0 0 CD cord-006856-b1w25ob5 44 17 ; ; : cord-006856-b1w25ob5 44 18 max max NNP cord-006856-b1w25ob5 44 19 , , , cord-006856-b1w25ob5 44 20 400 400 CD cord-006856-b1w25ob5 44 21 ] ] -RRB- cord-006856-b1w25ob5 44 22 days day NNS cord-006856-b1w25ob5 44 23 ) ) -RRB- cord-006856-b1w25ob5 44 24 . . . cord-006856-b1w25ob5 45 1 Regarding regard VBG cord-006856-b1w25ob5 45 2 the the DT cord-006856-b1w25ob5 45 3 disease disease NN cord-006856-b1w25ob5 45 4 - - HYPH cord-006856-b1w25ob5 45 5 specific specific JJ cord-006856-b1w25ob5 45 6 waiting wait VBG cord-006856-b1w25ob5 45 7 time time NN cord-006856-b1w25ob5 45 8 , , , cord-006856-b1w25ob5 45 9 PPH pph NN cord-006856-b1w25ob5 45 10 patients patient NNS cord-006856-b1w25ob5 45 11 had have VBD cord-006856-b1w25ob5 45 12 to to TO cord-006856-b1w25ob5 45 13 wait wait VB cord-006856-b1w25ob5 45 14 a a DT cord-006856-b1w25ob5 45 15 longer long JJR cord-006856-b1w25ob5 45 16 period period NN cord-006856-b1w25ob5 45 17 ( ( -LRB- cord-006856-b1w25ob5 45 18 133 133 CD cord-006856-b1w25ob5 45 19 ± ± CD cord-006856-b1w25ob5 45 20 128 128 CD cord-006856-b1w25ob5 45 21 days day NNS cord-006856-b1w25ob5 45 22 ) ) -RRB- cord-006856-b1w25ob5 45 23 for for IN cord-006856-b1w25ob5 45 24 their -PRON- PRP$ cord-006856-b1w25ob5 45 25 transplantation transplantation NN cord-006856-b1w25ob5 45 26 than than IN cord-006856-b1w25ob5 45 27 patients patient NNS cord-006856-b1w25ob5 45 28 with with IN cord-006856-b1w25ob5 45 29 other other JJ cord-006856-b1w25ob5 45 30 diagnosis diagnosis NN cord-006856-b1w25ob5 45 31 . . . cord-006856-b1w25ob5 46 1 Conclusions conclusion NNS cord-006856-b1w25ob5 46 2 . . . cord-006856-b1w25ob5 47 1 Waiting wait VBG cord-006856-b1w25ob5 47 2 time time NN cord-006856-b1w25ob5 47 3 and and CC cord-006856-b1w25ob5 47 4 mortality mortality NN cord-006856-b1w25ob5 47 5 on on IN cord-006856-b1w25ob5 47 6 the the DT cord-006856-b1w25ob5 47 7 waiting waiting NN cord-006856-b1w25ob5 47 8 list list NN cord-006856-b1w25ob5 47 9 are be VBP cord-006856-b1w25ob5 47 10 showing show VBG cord-006856-b1w25ob5 47 11 remarkable remarkable JJ cord-006856-b1w25ob5 47 12 differences difference NNS cord-006856-b1w25ob5 47 13 within within IN cord-006856-b1w25ob5 47 14 the the DT cord-006856-b1w25ob5 47 15 disease disease NN cord-006856-b1w25ob5 47 16 - - HYPH cord-006856-b1w25ob5 47 17 specific specific JJ cord-006856-b1w25ob5 47 18 subgroups subgroup NNS cord-006856-b1w25ob5 47 19 . . . cord-006856-b1w25ob5 48 1 V05 V05 NNP cord-006856-b1w25ob5 48 2 Increased Increased NNP cord-006856-b1w25ob5 48 3 recipient recipient NN cord-006856-b1w25ob5 48 4 VEGF VEGF NNP cord-006856-b1w25ob5 48 5 serum serum NN cord-006856-b1w25ob5 48 6 level level NN cord-006856-b1w25ob5 48 7 is be VBZ cord-006856-b1w25ob5 48 8 a a DT cord-006856-b1w25ob5 48 9 risk risk NN cord-006856-b1w25ob5 48 10 factor factor NN cord-006856-b1w25ob5 48 11 for for IN cord-006856-b1w25ob5 48 12 severe severe JJ cord-006856-b1w25ob5 48 13 reperfusion reperfusion NN cord-006856-b1w25ob5 48 14 edema edema NN cord-006856-b1w25ob5 48 15 after after IN cord-006856-b1w25ob5 48 16 lung lung NN cord-006856-b1w25ob5 48 17 transplantation transplantation NN cord-006856-b1w25ob5 48 18 K. K. NNP cord-006856-b1w25ob5 48 19 Krenn Krenn NNP cord-006856-b1w25ob5 48 20 , , , cord-006856-b1w25ob5 48 21 S. S. NNP cord-006856-b1w25ob5 48 22 Taghavi Taghavi NNP cord-006856-b1w25ob5 48 23 , , , cord-006856-b1w25ob5 48 24 W. W. NNP cord-006856-b1w25ob5 48 25 Klepetko Klepetko NNP cord-006856-b1w25ob5 48 26 , , , cord-006856-b1w25ob5 48 27 S. S. NNP cord-006856-b1w25ob5 48 28 Aharinejad Aharinejad NNP cord-006856-b1w25ob5 48 29 Laboratorium Laboratorium NNP cord-006856-b1w25ob5 48 30 für für IN cord-006856-b1w25ob5 48 31 Kardiovaskuläre Kardiovaskuläre NNP cord-006856-b1w25ob5 48 32 Forschung Forschung NNP cord-006856-b1w25ob5 48 33 , , , cord-006856-b1w25ob5 48 34 Zentrum Zentrum NNP cord-006856-b1w25ob5 48 35 für für IN cord-006856-b1w25ob5 48 36 Anatomie Anatomie NNP cord-006856-b1w25ob5 49 1 und und IN cord-006856-b1w25ob5 49 2 Zellbiologie Zellbiologie NNP cord-006856-b1w25ob5 49 3 , , , cord-006856-b1w25ob5 49 4 Medizinische Medizinische NNP cord-006856-b1w25ob5 49 5 Universität Universität NNP cord-006856-b1w25ob5 49 6 Wien Wien NNP cord-006856-b1w25ob5 49 7 , , , cord-006856-b1w25ob5 49 8 Wien Wien NNP cord-006856-b1w25ob5 49 9 , , , cord-006856-b1w25ob5 49 10 Österreich Österreich NNP cord-006856-b1w25ob5 49 11 Background Background NNP cord-006856-b1w25ob5 49 12 . . . cord-006856-b1w25ob5 50 1 Primary primary JJ cord-006856-b1w25ob5 50 2 graft graft NN cord-006856-b1w25ob5 50 3 dysfunction dysfunction NN cord-006856-b1w25ob5 50 4 ( ( -LRB- cord-006856-b1w25ob5 50 5 PGD PGD NNP cord-006856-b1w25ob5 50 6 ) ) -RRB- cord-006856-b1w25ob5 50 7 due due IN cord-006856-b1w25ob5 50 8 to to IN cord-006856-b1w25ob5 50 9 ischemia ischemia NN cord-006856-b1w25ob5 50 10 - - HYPH cord-006856-b1w25ob5 50 11 reperfusion reperfusion NN cord-006856-b1w25ob5 50 12 injury injury NN cord-006856-b1w25ob5 50 13 is be VBZ cord-006856-b1w25ob5 50 14 a a DT cord-006856-b1w25ob5 50 15 severe severe JJ cord-006856-b1w25ob5 50 16 complication complication NN cord-006856-b1w25ob5 50 17 in in IN cord-006856-b1w25ob5 50 18 lung lung NN cord-006856-b1w25ob5 50 19 transplantation transplantation NN cord-006856-b1w25ob5 50 20 ( ( -LRB- cord-006856-b1w25ob5 50 21 LTX LTX NNP cord-006856-b1w25ob5 50 22 ) ) -RRB- cord-006856-b1w25ob5 50 23 . . . cord-006856-b1w25ob5 51 1 Therapeutic therapeutic JJ cord-006856-b1w25ob5 51 2 strategies strategy NNS cord-006856-b1w25ob5 51 3 are be VBP cord-006856-b1w25ob5 51 4 limited limited JJ cord-006856-b1w25ob5 51 5 and and CC cord-006856-b1w25ob5 51 6 there there EX cord-006856-b1w25ob5 51 7 exist exist VBP cord-006856-b1w25ob5 51 8 no no DT cord-006856-b1w25ob5 51 9 preoperative preoperative JJ cord-006856-b1w25ob5 51 10 markers marker NNS cord-006856-b1w25ob5 51 11 to to TO cord-006856-b1w25ob5 51 12 predict predict VB cord-006856-b1w25ob5 51 13 the the DT cord-006856-b1w25ob5 51 14 risk risk NN cord-006856-b1w25ob5 51 15 for for IN cord-006856-b1w25ob5 51 16 reperfusion reperfusion NN cord-006856-b1w25ob5 51 17 - - HYPH cord-006856-b1w25ob5 51 18 induced induce VBN cord-006856-b1w25ob5 51 19 edema edema NN cord-006856-b1w25ob5 51 20 . . . cord-006856-b1w25ob5 52 1 Vascular vascular JJ cord-006856-b1w25ob5 52 2 endothelial endothelial JJ cord-006856-b1w25ob5 52 3 growth growth NN cord-006856-b1w25ob5 52 4 factor factor NN cord-006856-b1w25ob5 52 5 ( ( -LRB- cord-006856-b1w25ob5 52 6 VEGF VEGF NNP cord-006856-b1w25ob5 52 7 ) ) -RRB- cord-006856-b1w25ob5 52 8 is be VBZ cord-006856-b1w25ob5 52 9 a a DT cord-006856-b1w25ob5 52 10 key key JJ cord-006856-b1w25ob5 52 11 regulator regulator NN cord-006856-b1w25ob5 52 12 of of IN cord-006856-b1w25ob5 52 13 vascular vascular JJ cord-006856-b1w25ob5 52 14 permeability permeability NN cord-006856-b1w25ob5 52 15 . . . cord-006856-b1w25ob5 53 1 Methods method NNS cord-006856-b1w25ob5 53 2 . . . cord-006856-b1w25ob5 54 1 Preoperative Preoperative NNP cord-006856-b1w25ob5 54 2 VEGF vegf NN cord-006856-b1w25ob5 54 3 serum serum NN cord-006856-b1w25ob5 54 4 levels level NNS cord-006856-b1w25ob5 54 5 were be VBD cord-006856-b1w25ob5 54 6 measured measure VBN cord-006856-b1w25ob5 54 7 by by IN cord-006856-b1w25ob5 54 8 ELISA ELISA NNP cord-006856-b1w25ob5 54 9 for for IN cord-006856-b1w25ob5 54 10 76 76 CD cord-006856-b1w25ob5 54 11 patients patient NNS cord-006856-b1w25ob5 54 12 undergoing undergo VBG cord-006856-b1w25ob5 54 13 LTX LTX NNP cord-006856-b1w25ob5 54 14 . . . cord-006856-b1w25ob5 55 1 Underlying underlie VBG cord-006856-b1w25ob5 55 2 diseases disease NNS cord-006856-b1w25ob5 55 3 in in IN cord-006856-b1w25ob5 55 4 LTX LTX NNP cord-006856-b1w25ob5 55 5 patients patient NNS cord-006856-b1w25ob5 55 6 were be VBD cord-006856-b1w25ob5 55 7 COPD COPD NNP cord-006856-b1w25ob5 55 8 ( ( -LRB- cord-006856-b1w25ob5 55 9 n n NN cord-006856-b1w25ob5 55 10 = = SYM cord-006856-b1w25ob5 55 11 22 22 CD cord-006856-b1w25ob5 55 12 ) ) -RRB- cord-006856-b1w25ob5 55 13 , , , cord-006856-b1w25ob5 55 14 cystic cystic JJ cord-006856-b1w25ob5 55 15 fibrosis fibrosis NN cord-006856-b1w25ob5 56 1 ( ( -LRB- cord-006856-b1w25ob5 56 2 n n NN cord-006856-b1w25ob5 56 3 = = SYM cord-006856-b1w25ob5 56 4 15 15 CD cord-006856-b1w25ob5 56 5 ) ) -RRB- cord-006856-b1w25ob5 56 6 , , , cord-006856-b1w25ob5 56 7 idiopathic idiopathic JJ cord-006856-b1w25ob5 56 8 pulmonary pulmonary JJ cord-006856-b1w25ob5 56 9 fibrosis fibrosis NN cord-006856-b1w25ob5 57 1 ( ( -LRB- cord-006856-b1w25ob5 57 2 n n NN cord-006856-b1w25ob5 57 3 = = SYM cord-006856-b1w25ob5 57 4 11 11 CD cord-006856-b1w25ob5 57 5 ) ) -RRB- cord-006856-b1w25ob5 57 6 , , , cord-006856-b1w25ob5 57 7 emphysema emphysema NN cord-006856-b1w25ob5 57 8 ( ( -LRB- cord-006856-b1w25ob5 57 9 n n NN cord-006856-b1w25ob5 57 10 = = SYM cord-006856-b1w25ob5 57 11 6 6 CD cord-006856-b1w25ob5 57 12 ) ) -RRB- cord-006856-b1w25ob5 57 13 , , , cord-006856-b1w25ob5 57 14 primary primary JJ cord-006856-b1w25ob5 57 15 pulmonary pulmonary JJ cord-006856-b1w25ob5 57 16 hypertension hypertension NN cord-006856-b1w25ob5 57 17 ( ( -LRB- cord-006856-b1w25ob5 57 18 n n NN cord-006856-b1w25ob5 57 19 = = SYM cord-006856-b1w25ob5 57 20 6 6 CD cord-006856-b1w25ob5 57 21 ) ) -RRB- cord-006856-b1w25ob5 57 22 , , , cord-006856-b1w25ob5 57 23 sarcoidosis sarcoidosis NNP cord-006856-b1w25ob5 57 24 ( ( -LRB- cord-006856-b1w25ob5 57 25 n n NN cord-006856-b1w25ob5 57 26 = = SYM cord-006856-b1w25ob5 57 27 4 4 CD cord-006856-b1w25ob5 57 28 ) ) -RRB- cord-006856-b1w25ob5 57 29 , , , cord-006856-b1w25ob5 57 30 and and CC cord-006856-b1w25ob5 57 31 others other NNS cord-006856-b1w25ob5 57 32 ( ( -LRB- cord-006856-b1w25ob5 57 33 n n NN cord-006856-b1w25ob5 57 34 = = SYM cord-006856-b1w25ob5 57 35 12 12 CD cord-006856-b1w25ob5 57 36 ) ) -RRB- cord-006856-b1w25ob5 57 37 . . . cord-006856-b1w25ob5 58 1 The the DT cord-006856-b1w25ob5 58 2 ischemia ischemia NN cord-006856-b1w25ob5 58 3 time time NN cord-006856-b1w25ob5 58 4 of of IN cord-006856-b1w25ob5 58 5 the the DT cord-006856-b1w25ob5 58 6 grafts graft NNS cord-006856-b1w25ob5 58 7 and and CC cord-006856-b1w25ob5 58 8 the the DT cord-006856-b1w25ob5 58 9 blood blood NN cord-006856-b1w25ob5 58 10 gas gas NN cord-006856-b1w25ob5 58 11 parameters parameter NNS cord-006856-b1w25ob5 58 12 in in IN cord-006856-b1w25ob5 58 13 donors donor NNS cord-006856-b1w25ob5 58 14 were be VBD cord-006856-b1w25ob5 58 15 comparable comparable JJ cord-006856-b1w25ob5 58 16 . . . cord-006856-b1w25ob5 59 1 Reperfusion reperfusion NN cord-006856-b1w25ob5 59 2 edema edema NN cord-006856-b1w25ob5 59 3 was be VBD cord-006856-b1w25ob5 59 4 diagnosed diagnose VBN cord-006856-b1w25ob5 59 5 and and CC cord-006856-b1w25ob5 59 6 scored score VBN cord-006856-b1w25ob5 59 7 by by IN cord-006856-b1w25ob5 59 8 characteristic characteristic JJ cord-006856-b1w25ob5 59 9 changes change NNS cord-006856-b1w25ob5 59 10 in in IN cord-006856-b1w25ob5 59 11 chest chest NN cord-006856-b1w25ob5 59 12 radiographs radiograph NNS cord-006856-b1w25ob5 59 13 and and CC cord-006856-b1w25ob5 59 14 deteriorating deteriorate VBG cord-006856-b1w25ob5 59 15 blood blood NN cord-006856-b1w25ob5 59 16 gases gas NNS cord-006856-b1w25ob5 59 17 according accord VBG cord-006856-b1w25ob5 59 18 to to IN cord-006856-b1w25ob5 59 19 the the DT cord-006856-b1w25ob5 59 20 guidelines guideline NNS cord-006856-b1w25ob5 59 21 of of IN cord-006856-b1w25ob5 59 22 the the DT cord-006856-b1w25ob5 59 23 International International NNP cord-006856-b1w25ob5 59 24 Society Society NNP cord-006856-b1w25ob5 59 25 for for IN cord-006856-b1w25ob5 59 26 Heart Heart NNP cord-006856-b1w25ob5 59 27 and and CC cord-006856-b1w25ob5 59 28 Lung Lung NNP cord-006856-b1w25ob5 59 29 Transplantation Transplantation NNP cord-006856-b1w25ob5 59 30 , , , cord-006856-b1w25ob5 59 31 grading grade VBG cord-006856-b1w25ob5 59 32 PGD pgd NN cord-006856-b1w25ob5 59 33 from from IN cord-006856-b1w25ob5 59 34 0 0 CD cord-006856-b1w25ob5 59 35 to to IN cord-006856-b1w25ob5 59 36 3 3 CD cord-006856-b1w25ob5 59 37 ( ( -LRB- cord-006856-b1w25ob5 59 38 0 0 NFP cord-006856-b1w25ob5 59 39 , , , cord-006856-b1w25ob5 59 40 none none NN cord-006856-b1w25ob5 59 41 ; ; : cord-006856-b1w25ob5 59 42 1 1 CD cord-006856-b1w25ob5 59 43 , , , cord-006856-b1w25ob5 59 44 only only RB cord-006856-b1w25ob5 59 45 radiographic radiographic JJ cord-006856-b1w25ob5 59 46 evidence evidence NN cord-006856-b1w25ob5 59 47 ; ; : cord-006856-b1w25ob5 59 48 2 2 CD cord-006856-b1w25ob5 59 49 , , , cord-006856-b1w25ob5 59 50 moderate moderate JJ cord-006856-b1w25ob5 59 51 , , , cord-006856-b1w25ob5 59 52 PaO pao JJ cord-006856-b1w25ob5 59 53 2 2 CD cord-006856-b1w25ob5 59 54 /FiO /fio SYM cord-006856-b1w25ob5 59 55 2 2 CD cord-006856-b1w25ob5 59 56 ratio ratio NN cord-006856-b1w25ob5 59 57 of of IN cord-006856-b1w25ob5 59 58 200 200 CD cord-006856-b1w25ob5 59 59 - - SYM cord-006856-b1w25ob5 59 60 300 300 CD cord-006856-b1w25ob5 59 61 ; ; SYM cord-006856-b1w25ob5 59 62 3 3 CD cord-006856-b1w25ob5 59 63 , , , cord-006856-b1w25ob5 59 64 severe severe JJ cord-006856-b1w25ob5 59 65 , , , cord-006856-b1w25ob5 59 66 PaO pao JJ cord-006856-b1w25ob5 59 67 2 2 CD cord-006856-b1w25ob5 59 68 /FiO /fio SYM cord-006856-b1w25ob5 59 69 2 2 CD cord-006856-b1w25ob5 59 70 ratio ratio NN cord-006856-b1w25ob5 59 71 of of IN cord-006856-b1w25ob5 59 72 < < XX cord-006856-b1w25ob5 59 73 200 200 CD cord-006856-b1w25ob5 59 74 or or CC cord-006856-b1w25ob5 59 75 ECMO ECMO NNP cord-006856-b1w25ob5 59 76 support support VBP cord-006856-b1w25ob5 59 77 necessary necessary JJ cord-006856-b1w25ob5 59 78 ) ) -RRB- cord-006856-b1w25ob5 59 79 . . . cord-006856-b1w25ob5 60 1 Results result NNS cord-006856-b1w25ob5 60 2 . . . cord-006856-b1w25ob5 61 1 Grade grade NN cord-006856-b1w25ob5 61 2 3 3 CD cord-006856-b1w25ob5 61 3 PGD PGD NNP cord-006856-b1w25ob5 61 4 occurred occur VBD cord-006856-b1w25ob5 61 5 in in IN cord-006856-b1w25ob5 61 6 15 15 CD cord-006856-b1w25ob5 61 7 % % NN cord-006856-b1w25ob5 61 8 , , , cord-006856-b1w25ob5 61 9 grade grade NN cord-006856-b1w25ob5 61 10 2 2 CD cord-006856-b1w25ob5 61 11 in in IN cord-006856-b1w25ob5 61 12 23 23 CD cord-006856-b1w25ob5 61 13 % % NN cord-006856-b1w25ob5 61 14 , , , cord-006856-b1w25ob5 61 15 grade grade NN cord-006856-b1w25ob5 61 16 1 1 CD cord-006856-b1w25ob5 61 17 in in IN cord-006856-b1w25ob5 61 18 43 43 CD cord-006856-b1w25ob5 61 19 % % NN cord-006856-b1w25ob5 61 20 , , , cord-006856-b1w25ob5 61 21 and and CC cord-006856-b1w25ob5 61 22 grade grade NN cord-006856-b1w25ob5 61 23 0 0 CD cord-006856-b1w25ob5 61 24 in in IN cord-006856-b1w25ob5 61 25 19 19 CD cord-006856-b1w25ob5 61 26 % % NN cord-006856-b1w25ob5 61 27 of of IN cord-006856-b1w25ob5 61 28 the the DT cord-006856-b1w25ob5 61 29 patients patient NNS cord-006856-b1w25ob5 61 30 . . . cord-006856-b1w25ob5 62 1 The the DT cord-006856-b1w25ob5 62 2 preoperative preoperative JJ cord-006856-b1w25ob5 62 3 VEGF vegf NN cord-006856-b1w25ob5 62 4 serum serum NN cord-006856-b1w25ob5 62 5 levels level NNS cord-006856-b1w25ob5 62 6 were be VBD cord-006856-b1w25ob5 62 7 significantly significantly RB cord-006856-b1w25ob5 62 8 higher high JJR cord-006856-b1w25ob5 62 9 in in IN cord-006856-b1w25ob5 62 10 patients patient NNS cord-006856-b1w25ob5 62 11 with with IN cord-006856-b1w25ob5 62 12 PGD PGD NNP cord-006856-b1w25ob5 62 13 grade grade NN cord-006856-b1w25ob5 62 14 2 2 CD cord-006856-b1w25ob5 62 15 and and CC cord-006856-b1w25ob5 62 16 3 3 CD cord-006856-b1w25ob5 62 17 versus versus IN cord-006856-b1w25ob5 62 18 those those DT cord-006856-b1w25ob5 62 19 without without IN cord-006856-b1w25ob5 62 20 clinically clinically RB cord-006856-b1w25ob5 62 21 relevant relevant JJ cord-006856-b1w25ob5 62 22 PGD pgd NN cord-006856-b1w25ob5 62 23 ( ( -LRB- cord-006856-b1w25ob5 62 24 grade grade NN cord-006856-b1w25ob5 62 25 0 0 CD cord-006856-b1w25ob5 62 26 and and CC cord-006856-b1w25ob5 62 27 1 1 CD cord-006856-b1w25ob5 62 28 ) ) -RRB- cord-006856-b1w25ob5 62 29 following follow VBG cord-006856-b1w25ob5 62 30 LTX LTX NNP cord-006856-b1w25ob5 62 31 ( ( -LRB- cord-006856-b1w25ob5 62 32 P p NN cord-006856-b1w25ob5 62 33 = = SYM cord-006856-b1w25ob5 62 34 0.0007 0.0007 CD cord-006856-b1w25ob5 62 35 ) ) -RRB- cord-006856-b1w25ob5 62 36 . . . cord-006856-b1w25ob5 63 1 Preoperative Preoperative NNP cord-006856-b1w25ob5 63 2 recipient recipient NN cord-006856-b1w25ob5 64 1 VEGF VEGF NNP cord-006856-b1w25ob5 64 2 serum serum NN cord-006856-b1w25ob5 64 3 levels level NNS cord-006856-b1w25ob5 64 4 significantly significantly RB cord-006856-b1w25ob5 64 5 predicted predict VBD cord-006856-b1w25ob5 64 6 PGD PGD NNP cord-006856-b1w25ob5 64 7 in in IN cord-006856-b1w25ob5 64 8 receiver receiver NN cord-006856-b1w25ob5 64 9 operating operate VBG cord-006856-b1w25ob5 64 10 characteristic characteristic JJ cord-006856-b1w25ob5 64 11 analysis analysis NN cord-006856-b1w25ob5 64 12 ( ( -LRB- cord-006856-b1w25ob5 64 13 P p NN cord-006856-b1w25ob5 64 14 = = SYM cord-006856-b1w25ob5 64 15 0.0002 0.0002 CD cord-006856-b1w25ob5 64 16 , , , cord-006856-b1w25ob5 64 17 AUC AUC NNP cord-006856-b1w25ob5 64 18 = = SYM cord-006856-b1w25ob5 64 19 0.755 0.755 CD cord-006856-b1w25ob5 64 20 , , , cord-006856-b1w25ob5 64 21 CI CI NNP cord-006856-b1w25ob5 64 22 = = SYM cord-006856-b1w25ob5 64 23 1.001 1.001 CD cord-006856-b1w25ob5 64 24 - - HYPH cord-006856-b1w25ob5 64 25 1.003 1.003 CD cord-006856-b1w25ob5 64 26 ) ) -RRB- cord-006856-b1w25ob5 64 27 . . . cord-006856-b1w25ob5 65 1 Conclusions conclusion NNS cord-006856-b1w25ob5 65 2 . . . cord-006856-b1w25ob5 66 1 Preoperative Preoperative NNP cord-006856-b1w25ob5 66 2 serum serum NN cord-006856-b1w25ob5 66 3 VEGF vegf NN cord-006856-b1w25ob5 66 4 levels level NNS cord-006856-b1w25ob5 66 5 in in IN cord-006856-b1w25ob5 66 6 patients patient NNS cord-006856-b1w25ob5 66 7 awaiting await VBG cord-006856-b1w25ob5 66 8 LTX LTX NNP cord-006856-b1w25ob5 66 9 could could MD cord-006856-b1w25ob5 66 10 identify identify VB cord-006856-b1w25ob5 66 11 those those DT cord-006856-b1w25ob5 66 12 at at IN cord-006856-b1w25ob5 66 13 risk risk NN cord-006856-b1w25ob5 66 14 for for IN cord-006856-b1w25ob5 66 15 reperfusion reperfusion NN cord-006856-b1w25ob5 66 16 - - HYPH cord-006856-b1w25ob5 66 17 induced induce VBN cord-006856-b1w25ob5 66 18 edema edema NN cord-006856-b1w25ob5 66 19 following follow VBG cord-006856-b1w25ob5 66 20 transplantation transplantation NN cord-006856-b1w25ob5 66 21 . . . cord-006856-b1w25ob5 67 1 Background background NN cord-006856-b1w25ob5 67 2 . . . cord-006856-b1w25ob5 68 1 Airway Airway NNP cord-006856-b1w25ob5 68 2 stenoses stenosis NNS cord-006856-b1w25ob5 68 3 are be VBP cord-006856-b1w25ob5 68 4 well well RB cord-006856-b1w25ob5 68 5 known know VBN cord-006856-b1w25ob5 68 6 after after IN cord-006856-b1w25ob5 68 7 lung lung NN cord-006856-b1w25ob5 68 8 transplantation transplantation NN cord-006856-b1w25ob5 68 9 although although IN cord-006856-b1w25ob5 68 10 most most JJS cord-006856-b1w25ob5 68 11 occur occur VBP cord-006856-b1w25ob5 68 12 due due JJ cord-006856-b1w25ob5 68 13 to to IN cord-006856-b1w25ob5 68 14 surgical surgical JJ cord-006856-b1w25ob5 68 15 problems problem NNS cord-006856-b1w25ob5 68 16 of of IN cord-006856-b1w25ob5 68 17 the the DT cord-006856-b1w25ob5 68 18 bronchial bronchial JJ cord-006856-b1w25ob5 68 19 sutures suture NNS cord-006856-b1w25ob5 68 20 . . . cord-006856-b1w25ob5 69 1 We -PRON- PRP cord-006856-b1w25ob5 69 2 wanted want VBD cord-006856-b1w25ob5 69 3 to to TO cord-006856-b1w25ob5 69 4 analyse analyse VB cord-006856-b1w25ob5 69 5 the the DT cord-006856-b1w25ob5 69 6 use use NN cord-006856-b1w25ob5 69 7 of of IN cord-006856-b1w25ob5 69 8 endobronchial endobronchial JJ cord-006856-b1w25ob5 69 9 stenting stenting NN cord-006856-b1w25ob5 69 10 in in IN cord-006856-b1w25ob5 69 11 stenoses stenosis NNS cord-006856-b1w25ob5 69 12 not not RB cord-006856-b1w25ob5 69 13 related relate VBN cord-006856-b1w25ob5 69 14 to to IN cord-006856-b1w25ob5 69 15 the the DT cord-006856-b1w25ob5 69 16 bronchial bronchial JJ cord-006856-b1w25ob5 69 17 anastomoses anastomosis NNS cord-006856-b1w25ob5 69 18 . . . cord-006856-b1w25ob5 70 1 Methods method NNS cord-006856-b1w25ob5 70 2 . . . cord-006856-b1w25ob5 71 1 We -PRON- PRP cord-006856-b1w25ob5 71 2 performed perform VBD cord-006856-b1w25ob5 71 3 a a DT cord-006856-b1w25ob5 71 4 retrospective retrospective JJ cord-006856-b1w25ob5 71 5 analysis analysis NN cord-006856-b1w25ob5 71 6 in in IN cord-006856-b1w25ob5 71 7 12 12 CD cord-006856-b1w25ob5 71 8 patients patient NNS cord-006856-b1w25ob5 71 9 after after IN cord-006856-b1w25ob5 71 10 bilateral bilateral JJ cord-006856-b1w25ob5 71 11 lung lung NN cord-006856-b1w25ob5 71 12 transplantation transplantation NN cord-006856-b1w25ob5 71 13 with with IN cord-006856-b1w25ob5 71 14 consecutive consecutive JJ cord-006856-b1w25ob5 71 15 stent stent NN cord-006856-b1w25ob5 71 16 placement placement NN cord-006856-b1w25ob5 71 17 aside aside RB cord-006856-b1w25ob5 71 18 the the DT cord-006856-b1w25ob5 71 19 bronchial bronchial JJ cord-006856-b1w25ob5 71 20 anastomoses anastomosis NNS cord-006856-b1w25ob5 71 21 . . . cord-006856-b1w25ob5 72 1 The the DT cord-006856-b1w25ob5 72 2 indication indication NN cord-006856-b1w25ob5 72 3 for for IN cord-006856-b1w25ob5 72 4 stent stent JJ cord-006856-b1w25ob5 72 5 implantation implantation NN cord-006856-b1w25ob5 72 6 was be VBD cord-006856-b1w25ob5 72 7 central central JJ cord-006856-b1w25ob5 72 8 bronchial bronchial JJ cord-006856-b1w25ob5 72 9 stenoses stenosis NNS cord-006856-b1w25ob5 72 10 due due IN cord-006856-b1w25ob5 72 11 to to IN cord-006856-b1w25ob5 72 12 bronchomalacia bronchomalacia NN cord-006856-b1w25ob5 72 13 , , , cord-006856-b1w25ob5 72 14 granulation granulation NN cord-006856-b1w25ob5 72 15 tissue tissue NN cord-006856-b1w25ob5 72 16 with with IN cord-006856-b1w25ob5 72 17 bronchial bronchial JJ cord-006856-b1w25ob5 72 18 wall wall NN cord-006856-b1w25ob5 72 19 destruction destruction NN cord-006856-b1w25ob5 72 20 , , , cord-006856-b1w25ob5 72 21 and and CC cord-006856-b1w25ob5 72 22 endoluminal endoluminal JJ cord-006856-b1w25ob5 72 23 stenosis stenosis NN cord-006856-b1w25ob5 72 24 with with IN cord-006856-b1w25ob5 72 25 airflow airflow NN cord-006856-b1w25ob5 72 26 limitation limitation NN cord-006856-b1w25ob5 72 27 or or CC cord-006856-b1w25ob5 72 28 occurrence occurrence NN cord-006856-b1w25ob5 72 29 of of IN cord-006856-b1w25ob5 72 30 segmental segmental JJ cord-006856-b1w25ob5 72 31 or or CC cord-006856-b1w25ob5 72 32 lobar lobar JJ cord-006856-b1w25ob5 72 33 atelectasis atelectasis NN cord-006856-b1w25ob5 72 34 . . . cord-006856-b1w25ob5 73 1 We -PRON- PRP cord-006856-b1w25ob5 73 2 used use VBD cord-006856-b1w25ob5 73 3 Boston Boston NNP cord-006856-b1w25ob5 73 4 Ultraflex Ultraflex NNP cord-006856-b1w25ob5 73 5 ( ( -LRB- cord-006856-b1w25ob5 73 6 23 23 CD cord-006856-b1w25ob5 73 7 of of IN cord-006856-b1w25ob5 73 8 26 26 CD cord-006856-b1w25ob5 73 9 ) ) -RRB- cord-006856-b1w25ob5 73 10 , , , cord-006856-b1w25ob5 73 11 Rüsch Rüsch NNP cord-006856-b1w25ob5 73 12 Polyflex Polyflex NNP cord-006856-b1w25ob5 73 13 ( ( -LRB- cord-006856-b1w25ob5 73 14 2 2 CD cord-006856-b1w25ob5 73 15 of of IN cord-006856-b1w25ob5 73 16 26 26 CD cord-006856-b1w25ob5 73 17 ) ) -RRB- cord-006856-b1w25ob5 73 18 , , , cord-006856-b1w25ob5 73 19 Rüsch Rüsch NNP cord-006856-b1w25ob5 73 20 Dynamic Dynamic NNP cord-006856-b1w25ob5 73 21 ( ( -LRB- cord-006856-b1w25ob5 73 22 1 1 CD cord-006856-b1w25ob5 73 23 of of IN cord-006856-b1w25ob5 73 24 26 26 CD cord-006856-b1w25ob5 73 25 ) ) -RRB- cord-006856-b1w25ob5 73 26 stents stent NNS cord-006856-b1w25ob5 73 27 . . . cord-006856-b1w25ob5 74 1 Results result NNS cord-006856-b1w25ob5 74 2 . . . cord-006856-b1w25ob5 75 1 In in IN cord-006856-b1w25ob5 75 2 12 12 CD cord-006856-b1w25ob5 75 3 lung lung NN cord-006856-b1w25ob5 75 4 allograft allograft NN cord-006856-b1w25ob5 75 5 recipients recipient NNS cord-006856-b1w25ob5 75 6 , , , cord-006856-b1w25ob5 75 7 we -PRON- PRP cord-006856-b1w25ob5 75 8 implanted implant VBD cord-006856-b1w25ob5 75 9 in in IN cord-006856-b1w25ob5 75 10 total total JJ cord-006856-b1w25ob5 75 11 26 26 CD cord-006856-b1w25ob5 75 12 stents stent NNS cord-006856-b1w25ob5 75 13 between between IN cord-006856-b1w25ob5 75 14 2 2 CD cord-006856-b1w25ob5 75 15 and and CC cord-006856-b1w25ob5 75 16 72 72 CD cord-006856-b1w25ob5 75 17 month month NN cord-006856-b1w25ob5 75 18 after after IN cord-006856-b1w25ob5 75 19 bilateral bilateral JJ cord-006856-b1w25ob5 75 20 lung lung NN cord-006856-b1w25ob5 75 21 transplantation transplantation NN cord-006856-b1w25ob5 75 22 . . . cord-006856-b1w25ob5 76 1 The the DT cord-006856-b1w25ob5 76 2 predominant predominant JJ cord-006856-b1w25ob5 76 3 locations location NNS cord-006856-b1w25ob5 76 4 were be VBD cord-006856-b1w25ob5 76 5 the the DT cord-006856-b1w25ob5 76 6 right right NN cord-006856-b1w25ob5 76 7 ( ( -LRB- cord-006856-b1w25ob5 76 8 20 20 CD cord-006856-b1w25ob5 76 9 % % NN cord-006856-b1w25ob5 76 10 ) ) -RRB- cord-006856-b1w25ob5 76 11 and and CC cord-006856-b1w25ob5 76 12 left leave VBD cord-006856-b1w25ob5 76 13 lower low JJR cord-006856-b1w25ob5 76 14 lobe lobe NN cord-006856-b1w25ob5 76 15 bronchus bronchus NN cord-006856-b1w25ob5 76 16 ( ( -LRB- cord-006856-b1w25ob5 76 17 25 25 CD cord-006856-b1w25ob5 76 18 % % NN cord-006856-b1w25ob5 76 19 ) ) -RRB- cord-006856-b1w25ob5 76 20 and and CC cord-006856-b1w25ob5 76 21 the the DT cord-006856-b1w25ob5 76 22 bronchus bronchus NNP cord-006856-b1w25ob5 76 23 intermedius intermedius NNP cord-006856-b1w25ob5 76 24 ( ( -LRB- cord-006856-b1w25ob5 76 25 33 33 CD cord-006856-b1w25ob5 76 26 % % NN cord-006856-b1w25ob5 76 27 ) ) -RRB- cord-006856-b1w25ob5 76 28 . . . cord-006856-b1w25ob5 77 1 The the DT cord-006856-b1w25ob5 77 2 patient patient NN cord-006856-b1w25ob5 77 3 had have VBD cord-006856-b1w25ob5 77 4 granulation granulation NN cord-006856-b1w25ob5 77 5 tissue tissue NN cord-006856-b1w25ob5 77 6 proliferation proliferation NN cord-006856-b1w25ob5 77 7 due due IN cord-006856-b1w25ob5 77 8 to to IN cord-006856-b1w25ob5 77 9 ischemia ischemia NN cord-006856-b1w25ob5 77 10 and/or and/or CC cord-006856-b1w25ob5 77 11 chronic chronic JJ cord-006856-b1w25ob5 77 12 bacterial bacterial JJ cord-006856-b1w25ob5 77 13 or or CC cord-006856-b1w25ob5 77 14 fungal fungal JJ cord-006856-b1w25ob5 77 15 bronchitis bronchitis NN cord-006856-b1w25ob5 77 16 . . . cord-006856-b1w25ob5 78 1 Only only RB cord-006856-b1w25ob5 78 2 one one CD cord-006856-b1w25ob5 78 3 patient patient NN cord-006856-b1w25ob5 78 4 had have VBD cord-006856-b1w25ob5 78 5 concomitant concomitant JJ cord-006856-b1w25ob5 78 6 anastomoses anastomosis NNS cord-006856-b1w25ob5 78 7 dehiscence dehiscence NN cord-006856-b1w25ob5 78 8 . . . cord-006856-b1w25ob5 79 1 The the DT cord-006856-b1w25ob5 79 2 stents stent NNS cord-006856-b1w25ob5 79 3 remained remain VBD cord-006856-b1w25ob5 79 4 in in IN cord-006856-b1w25ob5 79 5 situ situ NN cord-006856-b1w25ob5 79 6 from from IN cord-006856-b1w25ob5 79 7 1 1 CD cord-006856-b1w25ob5 79 8 day day NN cord-006856-b1w25ob5 79 9 to to IN cord-006856-b1w25ob5 79 10 850 850 CD cord-006856-b1w25ob5 79 11 days day NNS cord-006856-b1w25ob5 79 12 after after IN cord-006856-b1w25ob5 79 13 placement placement NN cord-006856-b1w25ob5 79 14 . . . cord-006856-b1w25ob5 80 1 In in IN cord-006856-b1w25ob5 80 2 18 18 CD cord-006856-b1w25ob5 80 3 of of IN cord-006856-b1w25ob5 80 4 26 26 CD cord-006856-b1w25ob5 80 5 stent stent NN cord-006856-b1w25ob5 80 6 placements placement NNS cord-006856-b1w25ob5 80 7 no no DT cord-006856-b1w25ob5 80 8 severe severe JJ cord-006856-b1w25ob5 80 9 complications complication NNS cord-006856-b1w25ob5 80 10 occurred occur VBD cord-006856-b1w25ob5 80 11 . . . cord-006856-b1w25ob5 81 1 Stent stent NN cord-006856-b1w25ob5 81 2 migration migration NN cord-006856-b1w25ob5 81 3 was be VBD cord-006856-b1w25ob5 81 4 observed observe VBN cord-006856-b1w25ob5 81 5 in in IN cord-006856-b1w25ob5 81 6 6 6 CD cord-006856-b1w25ob5 81 7 of of IN cord-006856-b1w25ob5 81 8 26 26 CD cord-006856-b1w25ob5 81 9 ; ; , cord-006856-b1w25ob5 81 10 severe severe JJ cord-006856-b1w25ob5 81 11 granulation granulation NN cord-006856-b1w25ob5 81 12 tissue tissue NN cord-006856-b1w25ob5 81 13 that that WDT cord-006856-b1w25ob5 81 14 revealed reveal VBD cord-006856-b1w25ob5 81 15 further further JJ cord-006856-b1w25ob5 81 16 interventional interventional JJ cord-006856-b1w25ob5 81 17 treatment treatment NN cord-006856-b1w25ob5 81 18 , , , cord-006856-b1w25ob5 81 19 in in IN cord-006856-b1w25ob5 81 20 4 4 CD cord-006856-b1w25ob5 81 21 patients patient NNS cord-006856-b1w25ob5 81 22 . . . cord-006856-b1w25ob5 82 1 One one CD cord-006856-b1w25ob5 82 2 patient patient NN cord-006856-b1w25ob5 82 3 died die VBD cord-006856-b1w25ob5 82 4 because because IN cord-006856-b1w25ob5 82 5 of of IN cord-006856-b1w25ob5 82 6 necrotizing necrotize VBG cord-006856-b1w25ob5 82 7 vasculitis vasculitis NN cord-006856-b1w25ob5 82 8 and and CC cord-006856-b1w25ob5 82 9 letal letal JJ cord-006856-b1w25ob5 82 10 hemoptysis hemoptysis NN cord-006856-b1w25ob5 82 11 . . . cord-006856-b1w25ob5 83 1 All all DT cord-006856-b1w25ob5 83 2 other other JJ cord-006856-b1w25ob5 83 3 stents stent NNS cord-006856-b1w25ob5 83 4 are be VBP cord-006856-b1w25ob5 83 5 still still RB cord-006856-b1w25ob5 83 6 in in IN cord-006856-b1w25ob5 83 7 place place NN cord-006856-b1w25ob5 83 8 ( ( -LRB- cord-006856-b1w25ob5 83 9 10 10 CD cord-006856-b1w25ob5 83 10 of of IN cord-006856-b1w25ob5 83 11 26 26 CD cord-006856-b1w25ob5 83 12 ) ) -RRB- cord-006856-b1w25ob5 83 13 , , , cord-006856-b1w25ob5 83 14 were be VBD cord-006856-b1w25ob5 83 15 in in IN cord-006856-b1w25ob5 83 16 place place NN cord-006856-b1w25ob5 83 17 at at IN cord-006856-b1w25ob5 83 18 the the DT cord-006856-b1w25ob5 83 19 time time NN cord-006856-b1w25ob5 83 20 of of IN cord-006856-b1w25ob5 83 21 death death NN cord-006856-b1w25ob5 83 22 due due IN cord-006856-b1w25ob5 83 23 to to IN cord-006856-b1w25ob5 83 24 other other JJ cord-006856-b1w25ob5 83 25 reasons reason NNS cord-006856-b1w25ob5 83 26 ( ( -LRB- cord-006856-b1w25ob5 83 27 4 4 CD cord-006856-b1w25ob5 83 28 of of IN cord-006856-b1w25ob5 83 29 26 26 CD cord-006856-b1w25ob5 83 30 ) ) -RRB- cord-006856-b1w25ob5 83 31 , , , cord-006856-b1w25ob5 83 32 or or CC cord-006856-b1w25ob5 83 33 were be VBD cord-006856-b1w25ob5 83 34 explanted explante VBN cord-006856-b1w25ob5 83 35 regularly regularly RB cord-006856-b1w25ob5 83 36 ( ( -LRB- cord-006856-b1w25ob5 83 37 5 5 CD cord-006856-b1w25ob5 83 38 of of IN cord-006856-b1w25ob5 83 39 26 26 CD cord-006856-b1w25ob5 83 40 ) ) -RRB- cord-006856-b1w25ob5 83 41 . . . cord-006856-b1w25ob5 84 1 Conclusions conclusion NNS cord-006856-b1w25ob5 84 2 . . . cord-006856-b1w25ob5 85 1 Endobronchial endobronchial JJ cord-006856-b1w25ob5 85 2 stent stent NN cord-006856-b1w25ob5 85 3 placement placement NN cord-006856-b1w25ob5 85 4 is be VBZ cord-006856-b1w25ob5 85 5 an an DT cord-006856-b1w25ob5 85 6 effective effective JJ cord-006856-b1w25ob5 85 7 treatment treatment NN cord-006856-b1w25ob5 85 8 for for IN cord-006856-b1w25ob5 85 9 bronchial bronchial JJ cord-006856-b1w25ob5 85 10 stenoses stenosis NNS cord-006856-b1w25ob5 85 11 that that WDT cord-006856-b1w25ob5 85 12 are be VBP cord-006856-b1w25ob5 85 13 not not RB cord-006856-b1w25ob5 85 14 related relate VBN cord-006856-b1w25ob5 85 15 to to IN cord-006856-b1w25ob5 85 16 the the DT cord-006856-b1w25ob5 85 17 bronchial bronchial JJ cord-006856-b1w25ob5 85 18 anastomoses anastomosis NNS cord-006856-b1w25ob5 85 19 . . . cord-006856-b1w25ob5 86 1 Complications complication NNS cord-006856-b1w25ob5 86 2 occurred occur VBD cord-006856-b1w25ob5 86 3 in in IN cord-006856-b1w25ob5 86 4 about about RB cord-006856-b1w25ob5 86 5 40 40 CD cord-006856-b1w25ob5 86 6 % % NN cord-006856-b1w25ob5 86 7 of of IN cord-006856-b1w25ob5 86 8 all all DT cord-006856-b1w25ob5 86 9 stents stent NNS cord-006856-b1w25ob5 86 10 . . . cord-006856-b1w25ob5 87 1 V07 V07 NNP cord-006856-b1w25ob5 87 2 Preoperative Preoperative NNP cord-006856-b1w25ob5 87 3 oral oral JJ cord-006856-b1w25ob5 87 4 corticosteroids corticosteroid NNS cord-006856-b1w25ob5 87 5 predict predict VBP cord-006856-b1w25ob5 87 6 the the DT cord-006856-b1w25ob5 87 7 risk risk NN cord-006856-b1w25ob5 87 8 of of IN cord-006856-b1w25ob5 87 9 late late JJ cord-006856-b1w25ob5 87 10 postoperative postoperative JJ cord-006856-b1w25ob5 87 11 bleeding bleeding NN cord-006856-b1w25ob5 87 12 and and CC cord-006856-b1w25ob5 87 13 perioperative perioperative JJ cord-006856-b1w25ob5 87 14 mortality mortality NN cord-006856-b1w25ob5 87 15 in in IN cord-006856-b1w25ob5 87 16 lung lung NN cord-006856-b1w25ob5 87 17 transplantation transplantation NN cord-006856-b1w25ob5 87 18 Conclusions Conclusions NNPS cord-006856-b1w25ob5 87 19 . . . cord-006856-b1w25ob5 88 1 Patients patient NNS cord-006856-b1w25ob5 88 2 listed list VBN cord-006856-b1w25ob5 88 3 for for IN cord-006856-b1w25ob5 88 4 lung lung NN cord-006856-b1w25ob5 88 5 transplantation transplantation NN cord-006856-b1w25ob5 88 6 with with IN cord-006856-b1w25ob5 88 7 high high JJ cord-006856-b1w25ob5 88 8 - - HYPH cord-006856-b1w25ob5 88 9 dose dose NN cord-006856-b1w25ob5 88 10 preoperative preoperative JJ cord-006856-b1w25ob5 88 11 oral oral JJ cord-006856-b1w25ob5 88 12 CS cs NN cord-006856-b1w25ob5 88 13 intake intake NN cord-006856-b1w25ob5 89 1 have have VB cord-006856-b1w25ob5 89 2 a a DT cord-006856-b1w25ob5 89 3 significantly significantly RB cord-006856-b1w25ob5 89 4 increased increase VBN cord-006856-b1w25ob5 89 5 risk risk NN cord-006856-b1w25ob5 89 6 of of IN cord-006856-b1w25ob5 89 7 late late JJ cord-006856-b1w25ob5 89 8 postoperative postoperative JJ cord-006856-b1w25ob5 89 9 bleeding bleeding NN cord-006856-b1w25ob5 89 10 . . . cord-006856-b1w25ob5 90 1 The the DT cord-006856-b1w25ob5 90 2 perioperative perioperative JJ cord-006856-b1w25ob5 90 3 mortality mortality NN cord-006856-b1w25ob5 90 4 and and CC cord-006856-b1w25ob5 90 5 the the DT cord-006856-b1w25ob5 90 6 probability probability NN cord-006856-b1w25ob5 90 7 of of IN cord-006856-b1w25ob5 90 8 1-year 1-year CD cord-006856-b1w25ob5 90 9 survival survival NN cord-006856-b1w25ob5 90 10 of of IN cord-006856-b1w25ob5 90 11 recipients recipient NNS cord-006856-b1w25ob5 90 12 with with IN cord-006856-b1w25ob5 90 13 late late JJ cord-006856-b1w25ob5 90 14 bleeding bleeding NN cord-006856-b1w25ob5 90 15 are be VBP cord-006856-b1w25ob5 90 16 severely severely RB cord-006856-b1w25ob5 90 17 affected affect VBN cord-006856-b1w25ob5 90 18 compared compare VBN cord-006856-b1w25ob5 90 19 with with IN cord-006856-b1w25ob5 90 20 patients patient NNS cord-006856-b1w25ob5 90 21 with with IN cord-006856-b1w25ob5 90 22 no no DT cord-006856-b1w25ob5 90 23 or or CC cord-006856-b1w25ob5 90 24 early early JJ cord-006856-b1w25ob5 90 25 bleeding bleeding NN cord-006856-b1w25ob5 90 26 . . . cord-006856-b1w25ob5 91 1 Background background NN cord-006856-b1w25ob5 91 2 . . . cord-006856-b1w25ob5 92 1 The the DT cord-006856-b1w25ob5 92 2 efficacy efficacy NN cord-006856-b1w25ob5 92 3 of of IN cord-006856-b1w25ob5 92 4 induction induction NN cord-006856-b1w25ob5 92 5 therapy therapy NN cord-006856-b1w25ob5 92 6 after after IN cord-006856-b1w25ob5 92 7 lung lung NN cord-006856-b1w25ob5 92 8 transplantation transplantation NN cord-006856-b1w25ob5 92 9 remains remain VBZ cord-006856-b1w25ob5 92 10 controversial controversial JJ cord-006856-b1w25ob5 92 11 and and CC cord-006856-b1w25ob5 92 12 data datum NNS cord-006856-b1w25ob5 92 13 on on IN cord-006856-b1w25ob5 92 14 its -PRON- PRP$ cord-006856-b1w25ob5 92 15 use use NN cord-006856-b1w25ob5 92 16 are be VBP cord-006856-b1w25ob5 92 17 limited limited JJ cord-006856-b1w25ob5 92 18 . . . cord-006856-b1w25ob5 93 1 We -PRON- PRP cord-006856-b1w25ob5 93 2 hypothesized hypothesize VBD cord-006856-b1w25ob5 93 3 that that IN cord-006856-b1w25ob5 93 4 induction induction NN cord-006856-b1w25ob5 93 5 therapy therapy NN cord-006856-b1w25ob5 93 6 would would MD cord-006856-b1w25ob5 93 7 have have VB cord-006856-b1w25ob5 93 8 an an DT cord-006856-b1w25ob5 93 9 impact impact NN cord-006856-b1w25ob5 93 10 on on IN cord-006856-b1w25ob5 93 11 incidence incidence NN cord-006856-b1w25ob5 93 12 of of IN cord-006856-b1w25ob5 93 13 early early JJ cord-006856-b1w25ob5 93 14 rejection rejection NN cord-006856-b1w25ob5 93 15 after after IN cord-006856-b1w25ob5 93 16 lung lung NN cord-006856-b1w25ob5 93 17 transplantation transplantation NN cord-006856-b1w25ob5 93 18 and and CC cord-006856-b1w25ob5 93 19 may may MD cord-006856-b1w25ob5 93 20 cause cause VB cord-006856-b1w25ob5 93 21 a a DT cord-006856-b1w25ob5 93 22 higher high JJR cord-006856-b1w25ob5 93 23 rate rate NN cord-006856-b1w25ob5 93 24 of of IN cord-006856-b1w25ob5 93 25 infectious infectious JJ cord-006856-b1w25ob5 93 26 complications complication NNS cord-006856-b1w25ob5 93 27 during during IN cord-006856-b1w25ob5 93 28 the the DT cord-006856-b1w25ob5 93 29 first first JJ cord-006856-b1w25ob5 93 30 6 6 CD cord-006856-b1w25ob5 93 31 months month NNS cord-006856-b1w25ob5 93 32 post post NN cord-006856-b1w25ob5 93 33 transplantation transplantation NN cord-006856-b1w25ob5 93 34 . . . cord-006856-b1w25ob5 94 1 Methods method NNS cord-006856-b1w25ob5 94 2 . . . cord-006856-b1w25ob5 95 1 All all DT cord-006856-b1w25ob5 95 2 patients patient NNS cord-006856-b1w25ob5 95 3 who who WP cord-006856-b1w25ob5 95 4 underwent undergo VBD cord-006856-b1w25ob5 95 5 LuTX lutx NN cord-006856-b1w25ob5 95 6 between between IN cord-006856-b1w25ob5 95 7 Jannuary Jannuary NNP cord-006856-b1w25ob5 95 8 2003 2003 CD cord-006856-b1w25ob5 95 9 and and CC cord-006856-b1w25ob5 95 10 March March NNP cord-006856-b1w25ob5 95 11 2004 2004 CD cord-006856-b1w25ob5 95 12 and and CC cord-006856-b1w25ob5 95 13 received receive VBD cord-006856-b1w25ob5 95 14 induction induction NN cord-006856-b1w25ob5 95 15 therapy therapy NN cord-006856-b1w25ob5 95 16 with with IN cord-006856-b1w25ob5 95 17 rabbit rabbit NNP cord-006856-b1w25ob5 95 18 antithymocyte antithymocyte NNP cord-006856-b1w25ob5 95 19 globulin globulin NNP cord-006856-b1w25ob5 95 20 ( ( -LRB- cord-006856-b1w25ob5 95 21 2.5 2.5 CD cord-006856-b1w25ob5 95 22 mg mg NNP cord-006856-b1w25ob5 95 23 / / SYM cord-006856-b1w25ob5 95 24 kg kg NNP cord-006856-b1w25ob5 95 25 / / SYM cord-006856-b1w25ob5 95 26 d d NN cord-006856-b1w25ob5 95 27 for for IN cord-006856-b1w25ob5 95 28 3 3 CD cord-006856-b1w25ob5 95 29 - - SYM cord-006856-b1w25ob5 95 30 6 6 CD cord-006856-b1w25ob5 95 31 days day NNS cord-006856-b1w25ob5 95 32 ) ) -RRB- cord-006856-b1w25ob5 95 33 were be VBD cord-006856-b1w25ob5 95 34 analysed analyse VBN cord-006856-b1w25ob5 95 35 retrospectively retrospectively RB cord-006856-b1w25ob5 95 36 . . . cord-006856-b1w25ob5 96 1 Basic basic JJ cord-006856-b1w25ob5 96 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 96 3 consisted consist VBD cord-006856-b1w25ob5 96 4 of of IN cord-006856-b1w25ob5 96 5 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 96 6 , , , cord-006856-b1w25ob5 96 7 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 96 8 Mofetil Mofetil NNP cord-006856-b1w25ob5 96 9 , , , cord-006856-b1w25ob5 96 10 and and CC cord-006856-b1w25ob5 96 11 prednisone prednisone NN cord-006856-b1w25ob5 96 12 . . . cord-006856-b1w25ob5 97 1 Primary primary JJ cord-006856-b1w25ob5 97 2 end end NN cord-006856-b1w25ob5 97 3 point point NN cord-006856-b1w25ob5 97 4 was be VBD cord-006856-b1w25ob5 97 5 patient patient JJ cord-006856-b1w25ob5 97 6 survival survival NN cord-006856-b1w25ob5 97 7 after after IN cord-006856-b1w25ob5 97 8 6 6 CD cord-006856-b1w25ob5 97 9 months month NNS cord-006856-b1w25ob5 97 10 . . . cord-006856-b1w25ob5 98 1 Secondary secondary JJ cord-006856-b1w25ob5 98 2 end end NN cord-006856-b1w25ob5 98 3 point point NN cord-006856-b1w25ob5 98 4 was be VBD cord-006856-b1w25ob5 98 5 histologically histologically RB cord-006856-b1w25ob5 98 6 proven prove VBN cord-006856-b1w25ob5 98 7 grade grade NN cord-006856-b1w25ob5 98 8 I -PRON- PRP cord-006856-b1w25ob5 98 9 or or CC cord-006856-b1w25ob5 98 10 higher high JJR cord-006856-b1w25ob5 98 11 grade grade NN cord-006856-b1w25ob5 98 12 of of IN cord-006856-b1w25ob5 98 13 rejection rejection NN cord-006856-b1w25ob5 98 14 within within IN cord-006856-b1w25ob5 98 15 the the DT cord-006856-b1w25ob5 98 16 first first JJ cord-006856-b1w25ob5 98 17 6 6 CD cord-006856-b1w25ob5 98 18 months month NNS cord-006856-b1w25ob5 98 19 , , , cord-006856-b1w25ob5 98 20 incidence incidence NN cord-006856-b1w25ob5 98 21 of of IN cord-006856-b1w25ob5 98 22 infectious infectious JJ cord-006856-b1w25ob5 98 23 episodes episode NNS cord-006856-b1w25ob5 98 24 and and CC cord-006856-b1w25ob5 98 25 bronchiolitis bronchiolitis NNP cord-006856-b1w25ob5 98 26 obliterans obliterans NNP cord-006856-b1w25ob5 98 27 syndrome syndrome NNP cord-006856-b1w25ob5 98 28 ( ( -LRB- cord-006856-b1w25ob5 98 29 BOS BOS NNP cord-006856-b1w25ob5 98 30 ) ) -RRB- cord-006856-b1w25ob5 98 31 . . . cord-006856-b1w25ob5 99 1 A a DT cord-006856-b1w25ob5 99 2 total total NN cord-006856-b1w25ob5 99 3 of of IN cord-006856-b1w25ob5 99 4 29 29 CD cord-006856-b1w25ob5 99 5 adult adult NN cord-006856-b1w25ob5 99 6 patients patient NNS cord-006856-b1w25ob5 99 7 who who WP cord-006856-b1w25ob5 99 8 underwent undergo VBD cord-006856-b1w25ob5 99 9 single single JJ cord-006856-b1w25ob5 99 10 ( ( -LRB- cord-006856-b1w25ob5 99 11 n n NN cord-006856-b1w25ob5 99 12 = = SYM cord-006856-b1w25ob5 99 13 2 2 CD cord-006856-b1w25ob5 99 14 ) ) -RRB- cord-006856-b1w25ob5 99 15 , , , cord-006856-b1w25ob5 99 16 heart heart NN cord-006856-b1w25ob5 99 17 - - HYPH cord-006856-b1w25ob5 99 18 lung lung NN cord-006856-b1w25ob5 99 19 ( ( -LRB- cord-006856-b1w25ob5 99 20 n n NN cord-006856-b1w25ob5 99 21 = = SYM cord-006856-b1w25ob5 99 22 2 2 CD cord-006856-b1w25ob5 99 23 ) ) -RRB- cord-006856-b1w25ob5 99 24 , , , cord-006856-b1w25ob5 99 25 or or CC cord-006856-b1w25ob5 99 26 bilateral bilateral JJ cord-006856-b1w25ob5 99 27 lung lung NN cord-006856-b1w25ob5 99 28 ( ( -LRB- cord-006856-b1w25ob5 99 29 n n NN cord-006856-b1w25ob5 99 30 = = SYM cord-006856-b1w25ob5 99 31 26 26 CD cord-006856-b1w25ob5 99 32 ) ) -RRB- cord-006856-b1w25ob5 99 33 transplantation transplantation NN cord-006856-b1w25ob5 99 34 entered enter VBD cord-006856-b1w25ob5 99 35 the the DT cord-006856-b1w25ob5 99 36 study study NN cord-006856-b1w25ob5 99 37 . . . cord-006856-b1w25ob5 100 1 Female female JJ cord-006856-b1w25ob5 100 2 , , , cord-006856-b1w25ob5 100 3 10 10 CD cord-006856-b1w25ob5 100 4 ( ( -LRB- cord-006856-b1w25ob5 100 5 35 35 CD cord-006856-b1w25ob5 100 6 % % NN cord-006856-b1w25ob5 100 7 ) ) -RRB- cord-006856-b1w25ob5 100 8 ; ; : cord-006856-b1w25ob5 100 9 male male JJ cord-006856-b1w25ob5 100 10 , , , cord-006856-b1w25ob5 100 11 19 19 CD cord-006856-b1w25ob5 100 12 ( ( -LRB- cord-006856-b1w25ob5 100 13 65 65 CD cord-006856-b1w25ob5 100 14 % % NN cord-006856-b1w25ob5 100 15 ) ) -RRB- cord-006856-b1w25ob5 100 16 . . . cord-006856-b1w25ob5 101 1 Mean mean JJ cord-006856-b1w25ob5 101 2 age age NN cord-006856-b1w25ob5 101 3 was be VBD cord-006856-b1w25ob5 101 4 37 37 CD cord-006856-b1w25ob5 101 5 ± ± CD cord-006856-b1w25ob5 101 6 12.9 12.9 CD cord-006856-b1w25ob5 101 7 years year NNS cord-006856-b1w25ob5 101 8 ( ( -LRB- cord-006856-b1w25ob5 101 9 range range NN cord-006856-b1w25ob5 101 10 , , , cord-006856-b1w25ob5 101 11 19.3 19.3 CD cord-006856-b1w25ob5 101 12 - - HYPH cord-006856-b1w25ob5 101 13 59.9 59.9 CD cord-006856-b1w25ob5 101 14 years year NNS cord-006856-b1w25ob5 101 15 ) ) -RRB- cord-006856-b1w25ob5 101 16 . . . cord-006856-b1w25ob5 102 1 Results result NNS cord-006856-b1w25ob5 102 2 . . . cord-006856-b1w25ob5 103 1 The the DT cord-006856-b1w25ob5 103 2 6-month 6-month CD cord-006856-b1w25ob5 103 3 survival survival NN cord-006856-b1w25ob5 103 4 using use VBG cord-006856-b1w25ob5 103 5 Kaplan Kaplan NNP cord-006856-b1w25ob5 103 6 - - HYPH cord-006856-b1w25ob5 103 7 Meier Meier NNP cord-006856-b1w25ob5 103 8 analysis analysis NN cord-006856-b1w25ob5 103 9 was be VBD cord-006856-b1w25ob5 103 10 92 92 CD cord-006856-b1w25ob5 103 11 % % NN cord-006856-b1w25ob5 103 12 ; ; : cord-006856-b1w25ob5 103 13 27 27 CD cord-006856-b1w25ob5 103 14 patients patient NNS cord-006856-b1w25ob5 103 15 are be VBP cord-006856-b1w25ob5 103 16 alive alive JJ cord-006856-b1w25ob5 103 17 , , , cord-006856-b1w25ob5 103 18 two two CD cord-006856-b1w25ob5 103 19 died die VBD cord-006856-b1w25ob5 103 20 151 151 CD cord-006856-b1w25ob5 103 21 and and CC cord-006856-b1w25ob5 103 22 160 160 CD cord-006856-b1w25ob5 103 23 days day NNS cord-006856-b1w25ob5 103 24 after after IN cord-006856-b1w25ob5 103 25 transplantation transplantation NN cord-006856-b1w25ob5 103 26 . . . cord-006856-b1w25ob5 104 1 One one CD cord-006856-b1w25ob5 104 2 patient patient NN cord-006856-b1w25ob5 104 3 was be VBD cord-006856-b1w25ob5 104 4 retransplanted retransplanted JJ cord-006856-b1w25ob5 104 5 3 3 CD cord-006856-b1w25ob5 104 6 days day NNS cord-006856-b1w25ob5 104 7 after after IN cord-006856-b1w25ob5 104 8 primary primary JJ cord-006856-b1w25ob5 104 9 transplantation transplantation NN cord-006856-b1w25ob5 104 10 because because IN cord-006856-b1w25ob5 104 11 of of IN cord-006856-b1w25ob5 104 12 graft graft NN cord-006856-b1w25ob5 104 13 dysfunction dysfunction NN cord-006856-b1w25ob5 104 14 . . . cord-006856-b1w25ob5 105 1 Follow follow VB cord-006856-b1w25ob5 105 2 - - HYPH cord-006856-b1w25ob5 105 3 up up NN cord-006856-b1w25ob5 105 4 ranged range VBD cord-006856-b1w25ob5 105 5 from from IN cord-006856-b1w25ob5 105 6 a a DT cord-006856-b1w25ob5 105 7 minimum minimum NN cord-006856-b1w25ob5 105 8 of of IN cord-006856-b1w25ob5 105 9 151 151 CD cord-006856-b1w25ob5 105 10 days day NNS cord-006856-b1w25ob5 105 11 to to IN cord-006856-b1w25ob5 105 12 492 492 CD cord-006856-b1w25ob5 105 13 days day NNS cord-006856-b1w25ob5 105 14 ( ( -LRB- cord-006856-b1w25ob5 105 15 mean mean UH cord-006856-b1w25ob5 105 16 , , , cord-006856-b1w25ob5 105 17 279 279 CD cord-006856-b1w25ob5 105 18 ± ± CD cord-006856-b1w25ob5 105 19 85 85 CD cord-006856-b1w25ob5 105 20 days day NNS cord-006856-b1w25ob5 105 21 ) ) -RRB- cord-006856-b1w25ob5 105 22 . . . cord-006856-b1w25ob5 106 1 14 14 CD cord-006856-b1w25ob5 106 2 patients patient NNS cord-006856-b1w25ob5 106 3 had have VBD cord-006856-b1w25ob5 106 4 one one CD cord-006856-b1w25ob5 106 5 histologically histologically RB cord-006856-b1w25ob5 106 6 proven prove VBN cord-006856-b1w25ob5 106 7 rejection rejection NN cord-006856-b1w25ob5 106 8 episode episode NN cord-006856-b1w25ob5 106 9 . . . cord-006856-b1w25ob5 107 1 Rejections rejection NNS cord-006856-b1w25ob5 107 2 were be VBD cord-006856-b1w25ob5 107 3 graded grade VBN cord-006856-b1w25ob5 107 4 AI ai NN cord-006856-b1w25ob5 107 5 for for IN cord-006856-b1w25ob5 107 6 10 10 CD cord-006856-b1w25ob5 107 7 patients patient NNS cord-006856-b1w25ob5 107 8 , , , cord-006856-b1w25ob5 107 9 grade grade NN cord-006856-b1w25ob5 107 10 AI AI NNP cord-006856-b1w25ob5 107 11 - - HYPH cord-006856-b1w25ob5 107 12 II II NNP cord-006856-b1w25ob5 107 13 for for IN cord-006856-b1w25ob5 107 14 2 2 CD cord-006856-b1w25ob5 107 15 , , , cord-006856-b1w25ob5 107 16 and and CC cord-006856-b1w25ob5 107 17 grade grade NN cord-006856-b1w25ob5 107 18 AII aii NN cord-006856-b1w25ob5 107 19 for for IN cord-006856-b1w25ob5 107 20 2 2 CD cord-006856-b1w25ob5 107 21 patients patient NNS cord-006856-b1w25ob5 107 22 . . . cord-006856-b1w25ob5 108 1 7 7 CD cord-006856-b1w25ob5 108 2 rejection rejection NN cord-006856-b1w25ob5 108 3 episodes episode NNS cord-006856-b1w25ob5 108 4 were be VBD cord-006856-b1w25ob5 108 5 treated treat VBN cord-006856-b1w25ob5 108 6 with with IN cord-006856-b1w25ob5 108 7 iv iv NNP cord-006856-b1w25ob5 108 8 Methylprednisone Methylprednisone NNP cord-006856-b1w25ob5 108 9 , , , cord-006856-b1w25ob5 108 10 no no DT cord-006856-b1w25ob5 108 11 recurrent recurrent JJ cord-006856-b1w25ob5 108 12 or or CC cord-006856-b1w25ob5 108 13 ongoing ongoing JJ cord-006856-b1w25ob5 108 14 rejections rejection NNS cord-006856-b1w25ob5 108 15 were be VBD cord-006856-b1w25ob5 108 16 observed observe VBN cord-006856-b1w25ob5 108 17 . . . cord-006856-b1w25ob5 109 1 Incidence incidence NN cord-006856-b1w25ob5 109 2 of of IN cord-006856-b1w25ob5 109 3 bacterial bacterial JJ cord-006856-b1w25ob5 109 4 infections infection NNS cord-006856-b1w25ob5 109 5 requiring require VBG cord-006856-b1w25ob5 109 6 treatment treatment NN cord-006856-b1w25ob5 109 7 was be VBD cord-006856-b1w25ob5 109 8 21/100 21/100 CD cord-006856-b1w25ob5 109 9 patients patient NNS cord-006856-b1w25ob5 109 10 days day NNS cord-006856-b1w25ob5 109 11 . . . cord-006856-b1w25ob5 110 1 2 2 CD cord-006856-b1w25ob5 110 2 CMV CMV NNP cord-006856-b1w25ob5 110 3 infections infection NNS cord-006856-b1w25ob5 110 4 , , , cord-006856-b1w25ob5 110 5 1 1 CD cord-006856-b1w25ob5 110 6 non non JJ cord-006856-b1w25ob5 110 7 - - JJ cord-006856-b1w25ob5 110 8 CMV cmv JJ cord-006856-b1w25ob5 110 9 viral viral JJ cord-006856-b1w25ob5 110 10 infection infection NN cord-006856-b1w25ob5 110 11 , , , cord-006856-b1w25ob5 110 12 and and CC cord-006856-b1w25ob5 110 13 4 4 CD cord-006856-b1w25ob5 110 14 fungal fungal JJ cord-006856-b1w25ob5 110 15 infections infection NNS cord-006856-b1w25ob5 110 16 ( ( -LRB- cord-006856-b1w25ob5 110 17 2 2 CD cord-006856-b1w25ob5 110 18 Candida Candida NNP cord-006856-b1w25ob5 110 19 , , , cord-006856-b1w25ob5 110 20 2 2 CD cord-006856-b1w25ob5 110 21 Aspergillus aspergillus NN cord-006856-b1w25ob5 110 22 ) ) -RRB- cord-006856-b1w25ob5 110 23 were be VBD cord-006856-b1w25ob5 110 24 diagnosed diagnose VBN cord-006856-b1w25ob5 110 25 and and CC cord-006856-b1w25ob5 110 26 treated treat VBN cord-006856-b1w25ob5 110 27 . . . cord-006856-b1w25ob5 111 1 No no DT cord-006856-b1w25ob5 111 2 patient patient NN cord-006856-b1w25ob5 111 3 developed develop VBD cord-006856-b1w25ob5 111 4 signs sign NNS cord-006856-b1w25ob5 111 5 of of IN cord-006856-b1w25ob5 111 6 BOS BOS NNP cord-006856-b1w25ob5 111 7 of of IN cord-006856-b1w25ob5 111 8 grade grade NN cord-006856-b1w25ob5 111 9 ≥1 ≥1 NNP cord-006856-b1w25ob5 111 10 . . . cord-006856-b1w25ob5 112 1 No no DT cord-006856-b1w25ob5 112 2 lymphoma lymphoma NN cord-006856-b1w25ob5 112 3 occurred occur VBD cord-006856-b1w25ob5 112 4 . . . cord-006856-b1w25ob5 113 1 Conclusions conclusion NNS cord-006856-b1w25ob5 113 2 . . . cord-006856-b1w25ob5 114 1 This this DT cord-006856-b1w25ob5 114 2 retrospective retrospective JJ cord-006856-b1w25ob5 114 3 analysis analysis NN cord-006856-b1w25ob5 114 4 suggests suggest VBZ cord-006856-b1w25ob5 114 5 that that IN cord-006856-b1w25ob5 114 6 induction induction NN cord-006856-b1w25ob5 114 7 therapy therapy NN cord-006856-b1w25ob5 114 8 with with IN cord-006856-b1w25ob5 114 9 ATG ATG NNP cord-006856-b1w25ob5 114 10 in in IN cord-006856-b1w25ob5 114 11 combination combination NN cord-006856-b1w25ob5 114 12 with with IN cord-006856-b1w25ob5 114 13 Tacrolimusbased Tacrolimusbased NNP cord-006856-b1w25ob5 114 14 triple triple JJ cord-006856-b1w25ob5 114 15 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 114 16 regimen regimen NN cord-006856-b1w25ob5 114 17 results result NNS cord-006856-b1w25ob5 114 18 in in IN cord-006856-b1w25ob5 114 19 excellent excellent JJ cord-006856-b1w25ob5 114 20 survival survival NN cord-006856-b1w25ob5 114 21 rates rate NNS cord-006856-b1w25ob5 114 22 and and CC cord-006856-b1w25ob5 114 23 a a DT cord-006856-b1w25ob5 114 24 low low JJ cord-006856-b1w25ob5 114 25 rate rate NN cord-006856-b1w25ob5 114 26 of of IN cord-006856-b1w25ob5 114 27 acute acute JJ cord-006856-b1w25ob5 114 28 early early JJ cord-006856-b1w25ob5 114 29 rejections rejection NNS cord-006856-b1w25ob5 114 30 . . . cord-006856-b1w25ob5 115 1 However however RB cord-006856-b1w25ob5 115 2 , , , cord-006856-b1w25ob5 115 3 this this DT cord-006856-b1w25ob5 115 4 high high JJ cord-006856-b1w25ob5 115 5 immunosuppression immunosuppression NN cord-006856-b1w25ob5 115 6 efficacy efficacy NN cord-006856-b1w25ob5 115 7 was be VBD cord-006856-b1w25ob5 115 8 paralleled parallel VBN cord-006856-b1w25ob5 115 9 by by IN cord-006856-b1w25ob5 115 10 a a DT cord-006856-b1w25ob5 115 11 considerably considerably RB cord-006856-b1w25ob5 115 12 high high JJ cord-006856-b1w25ob5 115 13 rate rate NN cord-006856-b1w25ob5 115 14 of of IN cord-006856-b1w25ob5 115 15 bacterial bacterial JJ cord-006856-b1w25ob5 115 16 infections infection NNS cord-006856-b1w25ob5 115 17 during during IN cord-006856-b1w25ob5 115 18 the the DT cord-006856-b1w25ob5 115 19 first first JJ cord-006856-b1w25ob5 115 20 6 6 CD cord-006856-b1w25ob5 115 21 postoperative postoperative JJ cord-006856-b1w25ob5 115 22 months month NNS cord-006856-b1w25ob5 115 23 . . . cord-006856-b1w25ob5 116 1 rin rin NNP cord-006856-b1w25ob5 116 2 inhibitor inhibitor NNP cord-006856-b1w25ob5 116 3 based base VBD cord-006856-b1w25ob5 116 4 quadruple quadruple JJ cord-006856-b1w25ob5 116 5 drug drug NN cord-006856-b1w25ob5 116 6 IS be VBZ cord-006856-b1w25ob5 116 7 . . . cord-006856-b1w25ob5 117 1 An an DT cord-006856-b1w25ob5 117 2 extensive extensive JJ cord-006856-b1w25ob5 117 3 infectious infectious JJ cord-006856-b1w25ob5 117 4 monitoring monitoring NN cord-006856-b1w25ob5 117 5 was be VBD cord-006856-b1w25ob5 117 6 used use VBN cord-006856-b1w25ob5 117 7 in in IN cord-006856-b1w25ob5 117 8 this this DT cord-006856-b1w25ob5 117 9 cohort cohort NN cord-006856-b1w25ob5 117 10 . . . cord-006856-b1w25ob5 118 1 Results result NNS cord-006856-b1w25ob5 118 2 . . . cord-006856-b1w25ob5 119 1 One one CD cord-006856-b1w25ob5 119 2 - - HYPH cord-006856-b1w25ob5 119 3 year year NN cord-006856-b1w25ob5 119 4 patient patient NN cord-006856-b1w25ob5 119 5 survival survival NN cord-006856-b1w25ob5 119 6 was be VBD cord-006856-b1w25ob5 119 7 71.4 71.4 CD cord-006856-b1w25ob5 119 8 % % NN cord-006856-b1w25ob5 119 9 , , , cord-006856-b1w25ob5 119 10 perioperative perioperative JJ cord-006856-b1w25ob5 119 11 rejection rejection NN cord-006856-b1w25ob5 119 12 rate rate NN cord-006856-b1w25ob5 119 13 35 35 CD cord-006856-b1w25ob5 119 14 % % NN cord-006856-b1w25ob5 119 15 . . . cord-006856-b1w25ob5 120 1 Infection infection NN cord-006856-b1w25ob5 120 2 incidence incidence NN cord-006856-b1w25ob5 120 3 during during IN cord-006856-b1w25ob5 120 4 first first JJ cord-006856-b1w25ob5 120 5 hospitalization hospitalization NN cord-006856-b1w25ob5 120 6 was be VBD cord-006856-b1w25ob5 120 7 79.6 79.6 CD cord-006856-b1w25ob5 120 8 % % NN cord-006856-b1w25ob5 120 9 ( ( -LRB- cord-006856-b1w25ob5 120 10 1.3 1.3 CD cord-006856-b1w25ob5 120 11 episodes episode NNS cord-006856-b1w25ob5 120 12 per per IN cord-006856-b1w25ob5 120 13 transplant transplant NN cord-006856-b1w25ob5 120 14 ) ) -RRB- cord-006856-b1w25ob5 120 15 : : : cord-006856-b1w25ob5 121 1 pneumonia pneumonia NN cord-006856-b1w25ob5 121 2 , , , cord-006856-b1w25ob5 121 3 74 74 CD cord-006856-b1w25ob5 121 4 % % NN cord-006856-b1w25ob5 121 5 ; ; , cord-006856-b1w25ob5 121 6 sepsis sepsis NN cord-006856-b1w25ob5 121 7 , , , cord-006856-b1w25ob5 121 8 13 13 CD cord-006856-b1w25ob5 121 9 % % NN cord-006856-b1w25ob5 121 10 ; ; , cord-006856-b1w25ob5 121 11 wound wound NN cord-006856-b1w25ob5 121 12 infection infection NN cord-006856-b1w25ob5 121 13 , , , cord-006856-b1w25ob5 121 14 17 17 CD cord-006856-b1w25ob5 121 15 % % NN cord-006856-b1w25ob5 121 16 ; ; : cord-006856-b1w25ob5 121 17 HSV HSV NNP cord-006856-b1w25ob5 121 18 / / SYM cord-006856-b1w25ob5 121 19 VZV VZV NNP cord-006856-b1w25ob5 121 20 , , , cord-006856-b1w25ob5 121 21 28 28 CD cord-006856-b1w25ob5 121 22 % % NN cord-006856-b1w25ob5 121 23 ; ; : cord-006856-b1w25ob5 121 24 UTI UTI NNP cord-006856-b1w25ob5 121 25 , , , cord-006856-b1w25ob5 121 26 2 2 CD cord-006856-b1w25ob5 121 27 % % NN cord-006856-b1w25ob5 121 28 . . . cord-006856-b1w25ob5 122 1 During during IN cord-006856-b1w25ob5 122 2 follow follow NN cord-006856-b1w25ob5 122 3 - - HYPH cord-006856-b1w25ob5 122 4 up up NN cord-006856-b1w25ob5 122 5 , , , cord-006856-b1w25ob5 122 6 CMV CMV NNP cord-006856-b1w25ob5 122 7 - - HYPH cord-006856-b1w25ob5 122 8 associated associate VBN cord-006856-b1w25ob5 122 9 complications complication NNS cord-006856-b1w25ob5 122 10 were be VBD cord-006856-b1w25ob5 122 11 observed observe VBN cord-006856-b1w25ob5 122 12 in in IN cord-006856-b1w25ob5 122 13 50 50 CD cord-006856-b1w25ob5 122 14 % % NN cord-006856-b1w25ob5 122 15 of of IN cord-006856-b1w25ob5 122 16 patients patient NNS cord-006856-b1w25ob5 122 17 including include VBG cord-006856-b1w25ob5 122 18 CMV CMV NNP cord-006856-b1w25ob5 122 19 infection infection NN cord-006856-b1w25ob5 122 20 ( ( -LRB- cord-006856-b1w25ob5 122 21 n n NN cord-006856-b1w25ob5 122 22 = = SYM cord-006856-b1w25ob5 122 23 9 9 CD cord-006856-b1w25ob5 122 24 ) ) -RRB- cord-006856-b1w25ob5 122 25 , , , cord-006856-b1w25ob5 122 26 CMV CMV NNP cord-006856-b1w25ob5 122 27 disease disease NN cord-006856-b1w25ob5 122 28 ( ( -LRB- cord-006856-b1w25ob5 122 29 n n NN cord-006856-b1w25ob5 122 30 = = SYM cord-006856-b1w25ob5 122 31 16 16 CD cord-006856-b1w25ob5 122 32 ) ) -RRB- cord-006856-b1w25ob5 122 33 . . . cord-006856-b1w25ob5 123 1 There there EX cord-006856-b1w25ob5 123 2 were be VBD cord-006856-b1w25ob5 123 3 nine nine CD cord-006856-b1w25ob5 123 4 patients patient NNS cord-006856-b1w25ob5 123 5 with with IN cord-006856-b1w25ob5 123 6 CMV CMV NNP cord-006856-b1w25ob5 123 7 syndrome syndrome NN cord-006856-b1w25ob5 123 8 , , , cord-006856-b1w25ob5 123 9 ten ten CD cord-006856-b1w25ob5 123 10 patients patient NNS cord-006856-b1w25ob5 123 11 with with IN cord-006856-b1w25ob5 123 12 CMV CMV NNP cord-006856-b1w25ob5 123 13 graft graft NN cord-006856-b1w25ob5 123 14 pneumonitis pneumonitis NN cord-006856-b1w25ob5 123 15 and and CC cord-006856-b1w25ob5 123 16 two two CD cord-006856-b1w25ob5 123 17 patients patient NNS cord-006856-b1w25ob5 123 18 with with IN cord-006856-b1w25ob5 123 19 CMV CMV NNP cord-006856-b1w25ob5 123 20 gastrointestinal gastrointestinal JJ cord-006856-b1w25ob5 123 21 disease disease NN cord-006856-b1w25ob5 123 22 . . . cord-006856-b1w25ob5 124 1 Excluding exclude VBG cord-006856-b1w25ob5 124 2 the the DT cord-006856-b1w25ob5 124 3 3 3 CD cord-006856-b1w25ob5 124 4 retransplants retransplant NNS cord-006856-b1w25ob5 124 5 and and CC cord-006856-b1w25ob5 124 6 the the DT cord-006856-b1w25ob5 124 7 2 2 CD cord-006856-b1w25ob5 124 8 perioperative perioperative JJ cord-006856-b1w25ob5 124 9 deaths death NNS cord-006856-b1w25ob5 124 10 , , , cord-006856-b1w25ob5 124 11 the the DT cord-006856-b1w25ob5 124 12 incidence incidence NN cord-006856-b1w25ob5 124 13 of of IN cord-006856-b1w25ob5 124 14 aspergillosis aspergillosis NNP cord-006856-b1w25ob5 124 15 was be VBD cord-006856-b1w25ob5 124 16 27 27 CD cord-006856-b1w25ob5 124 17 % % NN cord-006856-b1w25ob5 124 18 , , , cord-006856-b1w25ob5 124 19 six six CD cord-006856-b1w25ob5 124 20 patients patient NNS cord-006856-b1w25ob5 124 21 with with IN cord-006856-b1w25ob5 124 22 Aspergillus Aspergillus NNP cord-006856-b1w25ob5 124 23 tracheobronchitis tracheobronchitis NN cord-006856-b1w25ob5 124 24 and and CC cord-006856-b1w25ob5 124 25 seven seven CD cord-006856-b1w25ob5 124 26 patients patient NNS cord-006856-b1w25ob5 124 27 with with IN cord-006856-b1w25ob5 124 28 invasive invasive JJ cord-006856-b1w25ob5 124 29 disease disease NN cord-006856-b1w25ob5 124 30 . . . cord-006856-b1w25ob5 125 1 A a DT cord-006856-b1w25ob5 125 2 total total NN cord-006856-b1w25ob5 125 3 of of IN cord-006856-b1w25ob5 125 4 33 33 CD cord-006856-b1w25ob5 125 5 patients patient NNS cord-006856-b1w25ob5 125 6 died die VBD cord-006856-b1w25ob5 125 7 during during IN cord-006856-b1w25ob5 125 8 follow follow NN cord-006856-b1w25ob5 125 9 - - HYPH cord-006856-b1w25ob5 125 10 up up NN cord-006856-b1w25ob5 125 11 , , , cord-006856-b1w25ob5 125 12 28 28 CD cord-006856-b1w25ob5 125 13 from from IN cord-006856-b1w25ob5 125 14 infectious infectious JJ cord-006856-b1w25ob5 125 15 complications complication NNS cord-006856-b1w25ob5 125 16 . . . cord-006856-b1w25ob5 126 1 As as IN cord-006856-b1w25ob5 126 2 part part NN cord-006856-b1w25ob5 126 3 of of IN cord-006856-b1w25ob5 126 4 our -PRON- PRP$ cord-006856-b1w25ob5 126 5 centers center NNS cord-006856-b1w25ob5 126 6 ' ' POS cord-006856-b1w25ob5 126 7 microbiological microbiological JJ cord-006856-b1w25ob5 126 8 monitoring monitoring NN cord-006856-b1w25ob5 126 9 , , , cord-006856-b1w25ob5 126 10 2773 2773 CD cord-006856-b1w25ob5 126 11 specimens specimen NNS cord-006856-b1w25ob5 126 12 ( ( -LRB- cord-006856-b1w25ob5 126 13 51 51 CD cord-006856-b1w25ob5 126 14 / / SYM cord-006856-b1w25ob5 126 15 transplant transplant NN cord-006856-b1w25ob5 126 16 ) ) -RRB- cord-006856-b1w25ob5 126 17 were be VBD cord-006856-b1w25ob5 126 18 collected collect VBN cord-006856-b1w25ob5 126 19 . . . cord-006856-b1w25ob5 127 1 These these DT cord-006856-b1w25ob5 127 2 specimens specimen NNS cord-006856-b1w25ob5 127 3 were be VBD cord-006856-b1w25ob5 127 4 taken take VBN cord-006856-b1w25ob5 127 5 on on IN cord-006856-b1w25ob5 127 6 1276 1276 CD cord-006856-b1w25ob5 127 7 observation observation NN cord-006856-b1w25ob5 127 8 days day NNS cord-006856-b1w25ob5 127 9 . . . cord-006856-b1w25ob5 128 1 1426 1426 CD cord-006856-b1w25ob5 128 2 investigated investigate VBN cord-006856-b1w25ob5 128 3 specimens specimen NNS cord-006856-b1w25ob5 128 4 were be VBD cord-006856-b1w25ob5 128 5 sterile sterile JJ cord-006856-b1w25ob5 128 6 and and CC cord-006856-b1w25ob5 128 7 in in IN cord-006856-b1w25ob5 128 8 993 993 CD cord-006856-b1w25ob5 128 9 specimens specimen NNS cord-006856-b1w25ob5 128 10 microorganisms microorganism NNS cord-006856-b1w25ob5 128 11 could could MD cord-006856-b1w25ob5 128 12 be be VB cord-006856-b1w25ob5 128 13 isolated isolate VBN cord-006856-b1w25ob5 128 14 ( ( -LRB- cord-006856-b1w25ob5 128 15 354 354 CD cord-006856-b1w25ob5 128 16 normal normal JJ cord-006856-b1w25ob5 128 17 flora flora NNS cord-006856-b1w25ob5 128 18 , , , cord-006856-b1w25ob5 128 19 639 639 CD cord-006856-b1w25ob5 128 20 pathogens pathogen NNS cord-006856-b1w25ob5 128 21 ) ) -RRB- cord-006856-b1w25ob5 128 22 . . . cord-006856-b1w25ob5 129 1 A a DT cord-006856-b1w25ob5 129 2 total total NN cord-006856-b1w25ob5 129 3 of of IN cord-006856-b1w25ob5 129 4 1155 1155 CD cord-006856-b1w25ob5 129 5 pathogens pathogen NNS cord-006856-b1w25ob5 129 6 were be VBD cord-006856-b1w25ob5 129 7 identified identify VBN cord-006856-b1w25ob5 129 8 : : : cord-006856-b1w25ob5 129 9 673 673 CD cord-006856-b1w25ob5 129 10 Gram gram NN cord-006856-b1w25ob5 129 11 - - HYPH cord-006856-b1w25ob5 129 12 positive positive JJ cord-006856-b1w25ob5 129 13 cocci coccus NNS cord-006856-b1w25ob5 129 14 , , , cord-006856-b1w25ob5 129 15 177 177 CD cord-006856-b1w25ob5 129 16 Gram gram NN cord-006856-b1w25ob5 129 17 - - HYPH cord-006856-b1w25ob5 129 18 negative negative JJ cord-006856-b1w25ob5 129 19 rods rod NNS cord-006856-b1w25ob5 129 20 , , , cord-006856-b1w25ob5 129 21 155 155 CD cord-006856-b1w25ob5 129 22 Pseudomonas Pseudomonas NNP cord-006856-b1w25ob5 129 23 / / SYM cord-006856-b1w25ob5 129 24 Acinetobacter Acinetobacter NNP cord-006856-b1w25ob5 129 25 , , , cord-006856-b1w25ob5 129 26 124 124 CD cord-006856-b1w25ob5 129 27 Candida Candida NNP cord-006856-b1w25ob5 129 28 . . . cord-006856-b1w25ob5 130 1 > > XX cord-006856-b1w25ob5 131 1 60 60 CD cord-006856-b1w25ob5 131 2 % % NN cord-006856-b1w25ob5 131 3 of of IN cord-006856-b1w25ob5 131 4 Staphylococcus Staphylococcus NNP cord-006856-b1w25ob5 131 5 aureus aureus NN cord-006856-b1w25ob5 131 6 and and CC cord-006856-b1w25ob5 131 7 55 55 CD cord-006856-b1w25ob5 131 8 % % NN cord-006856-b1w25ob5 131 9 of of IN cord-006856-b1w25ob5 131 10 coagulase coagulase NN cord-006856-b1w25ob5 131 11 - - HYPH cord-006856-b1w25ob5 131 12 negative negative JJ cord-006856-b1w25ob5 131 13 staphylococci staphylococcus NNS cord-006856-b1w25ob5 131 14 were be VBD cord-006856-b1w25ob5 131 15 methicillin methicillin NN cord-006856-b1w25ob5 131 16 resistant resistant JJ cord-006856-b1w25ob5 131 17 . . . cord-006856-b1w25ob5 132 1 Other other JJ cord-006856-b1w25ob5 132 2 multiresistant multiresistant NN cord-006856-b1w25ob5 132 3 organisms organism NNS cord-006856-b1w25ob5 132 4 were be VBD cord-006856-b1w25ob5 132 5 E. E. NNP cord-006856-b1w25ob5 132 6 faecium faecium NNP cord-006856-b1w25ob5 132 7 ( ( -LRB- cord-006856-b1w25ob5 132 8 no no DT cord-006856-b1w25ob5 132 9 VRE VRE NNP cord-006856-b1w25ob5 132 10 ) ) -RRB- cord-006856-b1w25ob5 132 11 , , . cord-006856-b1w25ob5 133 1 n n NN cord-006856-b1w25ob5 133 2 = = SYM cord-006856-b1w25ob5 133 3 75 75 CD cord-006856-b1w25ob5 133 4 ; ; : cord-006856-b1w25ob5 133 5 Corynebacterium Corynebacterium NNP cord-006856-b1w25ob5 133 6 JK JK NNP cord-006856-b1w25ob5 133 7 , , , cord-006856-b1w25ob5 133 8 n n NN cord-006856-b1w25ob5 133 9 = = SYM cord-006856-b1w25ob5 133 10 2 2 CD cord-006856-b1w25ob5 133 11 ; ; . cord-006856-b1w25ob5 134 1 Stenotrophomonas Stenotrophomonas NNP cord-006856-b1w25ob5 134 2 maltophila maltophila NNP cord-006856-b1w25ob5 134 3 / / SYM cord-006856-b1w25ob5 134 4 Burkholderia Burkholderia NNP cord-006856-b1w25ob5 134 5 cepacia cepacia NNP cord-006856-b1w25ob5 134 6 , , , cord-006856-b1w25ob5 134 7 n n NN cord-006856-b1w25ob5 134 8 = = SYM cord-006856-b1w25ob5 134 9 31 31 CD cord-006856-b1w25ob5 134 10 . . . cord-006856-b1w25ob5 135 1 Conclusions conclusion NNS cord-006856-b1w25ob5 135 2 . . . cord-006856-b1w25ob5 136 1 Infection infection NN cord-006856-b1w25ob5 136 2 remains remain VBZ cord-006856-b1w25ob5 136 3 the the DT cord-006856-b1w25ob5 136 4 most most RBS cord-006856-b1w25ob5 136 5 common common JJ cord-006856-b1w25ob5 136 6 complication complication NN cord-006856-b1w25ob5 136 7 and and CC cord-006856-b1w25ob5 136 8 the the DT cord-006856-b1w25ob5 136 9 most most RBS cord-006856-b1w25ob5 136 10 common common JJ cord-006856-b1w25ob5 136 11 cause cause NN cord-006856-b1w25ob5 136 12 of of IN cord-006856-b1w25ob5 136 13 death death NN cord-006856-b1w25ob5 136 14 following follow VBG cord-006856-b1w25ob5 136 15 lung lung NN cord-006856-b1w25ob5 136 16 transplantation transplantation NN cord-006856-b1w25ob5 136 17 . . . cord-006856-b1w25ob5 137 1 Further further JJ cord-006856-b1w25ob5 137 2 refinement refinement NN cord-006856-b1w25ob5 137 3 of of IN cord-006856-b1w25ob5 137 4 infectious infectious JJ cord-006856-b1w25ob5 137 5 prophylaxis prophylaxis NN cord-006856-b1w25ob5 137 6 is be VBZ cord-006856-b1w25ob5 137 7 required require VBN cord-006856-b1w25ob5 137 8 to to TO cord-006856-b1w25ob5 137 9 improve improve VB cord-006856-b1w25ob5 137 10 results result NNS cord-006856-b1w25ob5 137 11 . . . cord-006856-b1w25ob5 138 1 Background background NN cord-006856-b1w25ob5 138 2 . . . cord-006856-b1w25ob5 139 1 Valgancyclovir Valgancyclovir NNP cord-006856-b1w25ob5 139 2 is be VBZ cord-006856-b1w25ob5 139 3 routinely routinely RB cord-006856-b1w25ob5 139 4 used use VBN cord-006856-b1w25ob5 139 5 for for IN cord-006856-b1w25ob5 139 6 prophylaxis prophylaxis NN cord-006856-b1w25ob5 139 7 against against IN cord-006856-b1w25ob5 139 8 cytomegalovirus cytomegalovirus NNP cord-006856-b1w25ob5 139 9 ( ( -LRB- cord-006856-b1w25ob5 139 10 CMV CMV NNP cord-006856-b1w25ob5 139 11 ) ) -RRB- cord-006856-b1w25ob5 139 12 reactivation reactivation NN cord-006856-b1w25ob5 139 13 in in IN cord-006856-b1w25ob5 139 14 lung lung NN cord-006856-b1w25ob5 139 15 transplant transplant NN cord-006856-b1w25ob5 139 16 recipients recipient NNS cord-006856-b1w25ob5 139 17 . . . cord-006856-b1w25ob5 140 1 Problems problem NNS cord-006856-b1w25ob5 140 2 may may MD cord-006856-b1w25ob5 140 3 arise arise VB cord-006856-b1w25ob5 140 4 due due IN cord-006856-b1w25ob5 140 5 to to IN cord-006856-b1w25ob5 140 6 its -PRON- PRP$ cord-006856-b1w25ob5 140 7 myelotoxic myelotoxic JJ cord-006856-b1w25ob5 140 8 properties property NNS cord-006856-b1w25ob5 140 9 . . . cord-006856-b1w25ob5 141 1 It -PRON- PRP cord-006856-b1w25ob5 141 2 is be VBZ cord-006856-b1w25ob5 141 3 unclear unclear JJ cord-006856-b1w25ob5 141 4 whether whether IN cord-006856-b1w25ob5 141 5 Cytotect Cytotect NNP cord-006856-b1w25ob5 141 6 ® ® VBP cord-006856-b1w25ob5 141 7 , , , cord-006856-b1w25ob5 141 8 a a DT cord-006856-b1w25ob5 141 9 human human JJ cord-006856-b1w25ob5 141 10 IgG igg NN cord-006856-b1w25ob5 141 11 CMV CMV NNP cord-006856-b1w25ob5 141 12 antibody antibody NN cord-006856-b1w25ob5 141 13 preparation preparation NN cord-006856-b1w25ob5 141 14 , , , cord-006856-b1w25ob5 141 15 offers offer VBZ cord-006856-b1w25ob5 141 16 similar similar JJ cord-006856-b1w25ob5 141 17 protection protection NN cord-006856-b1w25ob5 141 18 against against IN cord-006856-b1w25ob5 141 19 CMV CMV NNP cord-006856-b1w25ob5 141 20 reactivation reactivation NN cord-006856-b1w25ob5 141 21 without without IN cord-006856-b1w25ob5 141 22 causing cause VBG cord-006856-b1w25ob5 141 23 neutropenia neutropenia NN cord-006856-b1w25ob5 141 24 . . . cord-006856-b1w25ob5 142 1 Methods method NNS cord-006856-b1w25ob5 142 2 . . . cord-006856-b1w25ob5 143 1 We -PRON- PRP cord-006856-b1w25ob5 143 2 report report VBP cord-006856-b1w25ob5 143 3 on on IN cord-006856-b1w25ob5 143 4 a a DT cord-006856-b1w25ob5 143 5 female female JJ cord-006856-b1w25ob5 143 6 patient patient NN cord-006856-b1w25ob5 143 7 ( ( -LRB- cord-006856-b1w25ob5 143 8 63 63 CD cord-006856-b1w25ob5 143 9 years year NNS cord-006856-b1w25ob5 143 10 ) ) -RRB- cord-006856-b1w25ob5 143 11 who who WP cord-006856-b1w25ob5 143 12 received receive VBD cord-006856-b1w25ob5 143 13 a a DT cord-006856-b1w25ob5 143 14 double double JJ cord-006856-b1w25ob5 143 15 lung lung NN cord-006856-b1w25ob5 143 16 transplant transplant NN cord-006856-b1w25ob5 143 17 in in IN cord-006856-b1w25ob5 143 18 2002 2002 CD cord-006856-b1w25ob5 143 19 . . . cord-006856-b1w25ob5 144 1 CMV CMV NNP cord-006856-b1w25ob5 144 2 status status NN cord-006856-b1w25ob5 144 3 was be VBD cord-006856-b1w25ob5 144 4 D+R+ D+R+ VBN cord-006856-b1w25ob5 144 5 . . . cord-006856-b1w25ob5 145 1 Four four CD cord-006856-b1w25ob5 145 2 months month NNS cord-006856-b1w25ob5 145 3 postoperatively postoperatively RB cord-006856-b1w25ob5 145 4 , , , cord-006856-b1w25ob5 145 5 she -PRON- PRP cord-006856-b1w25ob5 145 6 developped developpe VBD cord-006856-b1w25ob5 145 7 CMV CMV NNP cord-006856-b1w25ob5 145 8 pneumonitis pneumonitis NN cord-006856-b1w25ob5 145 9 and and CC cord-006856-b1w25ob5 145 10 gastroduodenitis gastroduodenitis NNP cord-006856-b1w25ob5 145 11 and and CC cord-006856-b1w25ob5 145 12 was be VBD cord-006856-b1w25ob5 145 13 treated treat VBN cord-006856-b1w25ob5 145 14 with with IN cord-006856-b1w25ob5 145 15 gancyclovir gancyclovir NNP cord-006856-b1w25ob5 145 16 and and CC cord-006856-b1w25ob5 145 17 Cytotect Cytotect NNP cord-006856-b1w25ob5 145 18 . . . cord-006856-b1w25ob5 146 1 Thereafter thereafter RB cord-006856-b1w25ob5 146 2 , , , cord-006856-b1w25ob5 146 3 valgancyclovir valgancyclovir NNP cord-006856-b1w25ob5 146 4 was be VBD cord-006856-b1w25ob5 146 5 instituted institute VBN cord-006856-b1w25ob5 146 6 but but CC cord-006856-b1w25ob5 146 7 had have VBD cord-006856-b1w25ob5 146 8 to to TO cord-006856-b1w25ob5 146 9 be be VB cord-006856-b1w25ob5 146 10 stopped stop VBN cord-006856-b1w25ob5 146 11 repeatedly repeatedly RB cord-006856-b1w25ob5 146 12 because because IN cord-006856-b1w25ob5 146 13 of of IN cord-006856-b1w25ob5 146 14 neutropenia neutropenia NN cord-006856-b1w25ob5 146 15 ; ; : cord-006856-b1w25ob5 146 16 each each DT cord-006856-b1w25ob5 146 17 withdrawal withdrawal NN cord-006856-b1w25ob5 146 18 of of IN cord-006856-b1w25ob5 146 19 valgancyclovir valgancyclovir NNS cord-006856-b1w25ob5 146 20 prompted prompt VBD cord-006856-b1w25ob5 146 21 further further JJ cord-006856-b1w25ob5 146 22 reactivation reactivation NN cord-006856-b1w25ob5 146 23 episodes episode NNS cord-006856-b1w25ob5 146 24 as as IN cord-006856-b1w25ob5 146 25 detected detect VBN cord-006856-b1w25ob5 146 26 by by IN cord-006856-b1w25ob5 146 27 pp65 pp65 NN cord-006856-b1w25ob5 146 28 monitoring monitor VBG cord-006856-b1w25ob5 146 29 . . . cord-006856-b1w25ob5 147 1 In in IN cord-006856-b1w25ob5 147 2 July July NNP cord-006856-b1w25ob5 147 3 2004 2004 CD cord-006856-b1w25ob5 147 4 , , , cord-006856-b1w25ob5 147 5 she -PRON- PRP cord-006856-b1w25ob5 147 6 was be VBD cord-006856-b1w25ob5 147 7 started start VBN cord-006856-b1w25ob5 147 8 on on IN cord-006856-b1w25ob5 147 9 Cytotect Cytotect NNP cord-006856-b1w25ob5 147 10 , , , cord-006856-b1w25ob5 147 11 150 150 CD cord-006856-b1w25ob5 147 12 mg mg NNP cord-006856-b1w25ob5 147 13 q.d q.d NNP cord-006856-b1w25ob5 147 14 . . . cord-006856-b1w25ob5 148 1 over over IN cord-006856-b1w25ob5 148 2 five five CD cord-006856-b1w25ob5 148 3 days day NNS cord-006856-b1w25ob5 148 4 , , , cord-006856-b1w25ob5 148 5 followed follow VBN cord-006856-b1w25ob5 148 6 by by IN cord-006856-b1w25ob5 148 7 weekly weekly JJ cord-006856-b1w25ob5 148 8 doses dose NNS cord-006856-b1w25ob5 148 9 of of IN cord-006856-b1w25ob5 148 10 50 50 CD cord-006856-b1w25ob5 148 11 mg mg NN cord-006856-b1w25ob5 148 12 for for IN cord-006856-b1w25ob5 148 13 twelve twelve CD cord-006856-b1w25ob5 148 14 weeks week NNS cord-006856-b1w25ob5 148 15 . . . cord-006856-b1w25ob5 149 1 Results result NNS cord-006856-b1w25ob5 149 2 . . . cord-006856-b1w25ob5 150 1 Cytotect Cytotect NNP cord-006856-b1w25ob5 150 2 was be VBD cord-006856-b1w25ob5 150 3 tolerated tolerate VBN cord-006856-b1w25ob5 150 4 without without IN cord-006856-b1w25ob5 150 5 side side NN cord-006856-b1w25ob5 150 6 effects effect NNS cord-006856-b1w25ob5 150 7 . . . cord-006856-b1w25ob5 151 1 Of of IN cord-006856-b1w25ob5 151 2 note note VB cord-006856-b1w25ob5 151 3 , , , cord-006856-b1w25ob5 151 4 leucocyte leucocyte NNP cord-006856-b1w25ob5 151 5 counts count NNS cord-006856-b1w25ob5 151 6 remained remain VBD cord-006856-b1w25ob5 151 7 within within IN cord-006856-b1w25ob5 151 8 normal normal JJ cord-006856-b1w25ob5 151 9 limits limit NNS cord-006856-b1w25ob5 151 10 . . . cord-006856-b1w25ob5 152 1 Since since IN cord-006856-b1w25ob5 152 2 she -PRON- PRP cord-006856-b1w25ob5 152 3 has have VBZ cord-006856-b1w25ob5 152 4 been be VBN cord-006856-b1w25ob5 152 5 started start VBN cord-006856-b1w25ob5 152 6 on on IN cord-006856-b1w25ob5 152 7 Cytotect Cytotect NNP cord-006856-b1w25ob5 152 8 , , , cord-006856-b1w25ob5 152 9 she -PRON- PRP cord-006856-b1w25ob5 152 10 has have VBZ cord-006856-b1w25ob5 152 11 not not RB cord-006856-b1w25ob5 152 12 experienced experience VBN cord-006856-b1w25ob5 152 13 any any DT cord-006856-b1w25ob5 152 14 further further JJ cord-006856-b1w25ob5 152 15 episodes episode NNS cord-006856-b1w25ob5 152 16 of of IN cord-006856-b1w25ob5 152 17 CMV CMV NNP cord-006856-b1w25ob5 152 18 reactivation reactivation NN cord-006856-b1w25ob5 152 19 until until IN cord-006856-b1w25ob5 152 20 to to IN cord-006856-b1w25ob5 152 21 date date NN cord-006856-b1w25ob5 152 22 . . . cord-006856-b1w25ob5 153 1 Conclusions conclusion NNS cord-006856-b1w25ob5 153 2 . . . cord-006856-b1w25ob5 154 1 The the DT cord-006856-b1w25ob5 154 2 observations observation NNS cord-006856-b1w25ob5 154 3 made make VBN cord-006856-b1w25ob5 154 4 in in IN cord-006856-b1w25ob5 154 5 this this DT cord-006856-b1w25ob5 154 6 patient patient NN cord-006856-b1w25ob5 154 7 suggest suggest VBP cord-006856-b1w25ob5 154 8 that that IN cord-006856-b1w25ob5 154 9 long long JJ cord-006856-b1w25ob5 154 10 - - HYPH cord-006856-b1w25ob5 154 11 term term NN cord-006856-b1w25ob5 154 12 therapy therapy NN cord-006856-b1w25ob5 154 13 with with IN cord-006856-b1w25ob5 154 14 Cytotect Cytotect NNP cord-006856-b1w25ob5 154 15 ® ® VBP cord-006856-b1w25ob5 154 16 has have VBZ cord-006856-b1w25ob5 154 17 the the DT cord-006856-b1w25ob5 154 18 potential potential NN cord-006856-b1w25ob5 154 19 to to TO cord-006856-b1w25ob5 154 20 prevent prevent VB cord-006856-b1w25ob5 154 21 CMV CMV NNP cord-006856-b1w25ob5 154 22 reactivation reactivation NN cord-006856-b1w25ob5 154 23 in in IN cord-006856-b1w25ob5 154 24 selected select VBN cord-006856-b1w25ob5 154 25 patients patient NNS cord-006856-b1w25ob5 154 26 who who WP cord-006856-b1w25ob5 154 27 do do VBP cord-006856-b1w25ob5 154 28 not not RB cord-006856-b1w25ob5 154 29 tolerate tolerate VB cord-006856-b1w25ob5 154 30 valgancyclovir valgancyclovir NNS cord-006856-b1w25ob5 154 31 due due JJ cord-006856-b1w25ob5 154 32 to to IN cord-006856-b1w25ob5 154 33 its -PRON- PRP$ cord-006856-b1w25ob5 154 34 myelotoxic myelotoxic JJ cord-006856-b1w25ob5 154 35 side side NN cord-006856-b1w25ob5 154 36 effects effect NNS cord-006856-b1w25ob5 154 37 . . . cord-006856-b1w25ob5 155 1 V12 V12 NNP cord-006856-b1w25ob5 155 2 Die die VB cord-006856-b1w25ob5 155 3 Kombinationsprophylaxe Kombinationsprophylaxe NNP cord-006856-b1w25ob5 155 4 verbessert verbessert RB cord-006856-b1w25ob5 155 5 die die VB cord-006856-b1w25ob5 156 1 CMV CMV NNP cord-006856-b1w25ob5 156 2 bedingte bedingte NN cord-006856-b1w25ob5 156 3 Morbidität Morbidität NNP cord-006856-b1w25ob5 156 4 und und IN cord-006856-b1w25ob5 156 5 Mortalität Mortalität NNP cord-006856-b1w25ob5 156 6 und und XX cord-006856-b1w25ob5 157 1 reduziert reduziert NNP cord-006856-b1w25ob5 157 2 das das NNP cord-006856-b1w25ob5 157 3 Risiko Risiko NNP cord-006856-b1w25ob5 157 4 der der NNP cord-006856-b1w25ob5 157 5 Bronchiolitis Bronchiolitis NNP cord-006856-b1w25ob5 157 6 obliterans obliterans NN cord-006856-b1w25ob5 157 7 ( ( -LRB- cord-006856-b1w25ob5 157 8 BOS BOS NNP cord-006856-b1w25ob5 157 9 ) ) -RRB- cord-006856-b1w25ob5 157 10 nach nach NNP cord-006856-b1w25ob5 157 11 Lungentransplantation Lungentransplantation NNP cord-006856-b1w25ob5 157 12 E. E. NNP cord-006856-b1w25ob5 157 13 Ruttmann Ruttmann NNP cord-006856-b1w25ob5 157 14 , , , cord-006856-b1w25ob5 157 15 C. C. NNP cord-006856-b1w25ob5 157 16 Geltner Geltner NNP cord-006856-b1w25ob5 157 17 , , , cord-006856-b1w25ob5 157 18 B. B. NNP cord-006856-b1w25ob5 157 19 Bucher Bucher NNP cord-006856-b1w25ob5 157 20 , , , cord-006856-b1w25ob5 157 21 H. H. NNP cord-006856-b1w25ob5 157 22 Ulmer Ulmer NNP cord-006856-b1w25ob5 157 23 , , , cord-006856-b1w25ob5 157 24 D. D. NNP cord-006856-b1w25ob5 157 25 Höfer Höfer NNP cord-006856-b1w25ob5 157 26 , , , cord-006856-b1w25ob5 157 27 H. H. NNP cord-006856-b1w25ob5 157 28 B. B. NNP cord-006856-b1w25ob5 157 29 Hangler Hangler NNP cord-006856-b1w25ob5 157 30 , , , cord-006856-b1w25ob5 157 31 S. S. NNP cord-006856-b1w25ob5 157 32 Semsroth Semsroth NNP cord-006856-b1w25ob5 157 33 , , , cord-006856-b1w25ob5 157 34 H. H. NNP cord-006856-b1w25ob5 157 35 Bonatti Bonatti NNP cord-006856-b1w25ob5 157 36 , , , cord-006856-b1w25ob5 157 37 R. R. NNP cord-006856-b1w25ob5 157 38 Margreiter Margreiter NNP cord-006856-b1w25ob5 157 39 , , , cord-006856-b1w25ob5 157 40 G. G. NNP cord-006856-b1w25ob5 157 41 Laufer Laufer NNP cord-006856-b1w25ob5 157 42 , , , cord-006856-b1w25ob5 157 43 L. L. NNP cord-006856-b1w25ob5 157 44 Müller Müller NNP cord-006856-b1w25ob5 157 45 Klinische Klinische NNP cord-006856-b1w25ob5 157 46 Abteilung Abteilung NNP cord-006856-b1w25ob5 157 47 für für IN cord-006856-b1w25ob5 157 48 Herzchirurgie Herzchirurgie NNP cord-006856-b1w25ob5 157 49 , , , cord-006856-b1w25ob5 157 50 Universitätsklinik Universitätsklinik NNP cord-006856-b1w25ob5 157 51 für für IN cord-006856-b1w25ob5 157 52 Chirurgie Chirurgie NNP cord-006856-b1w25ob5 157 53 , , , cord-006856-b1w25ob5 157 54 Medizinische Medizinische NNP cord-006856-b1w25ob5 157 55 Universität Universität NNP cord-006856-b1w25ob5 157 56 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 157 57 , , , cord-006856-b1w25ob5 157 58 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 157 59 , , , cord-006856-b1w25ob5 157 60 Österreich Österreich NNP cord-006856-b1w25ob5 157 61 Grundlagen Grundlagen NNP cord-006856-b1w25ob5 157 62 . . . cord-006856-b1w25ob5 158 1 Die die VB cord-006856-b1w25ob5 158 2 opportunistische opportunistische NN cord-006856-b1w25ob5 159 1 CMV CMV NNP cord-006856-b1w25ob5 159 2 - - HYPH cord-006856-b1w25ob5 159 3 Infektion Infektion NNP cord-006856-b1w25ob5 159 4 stellt stellt NNP cord-006856-b1w25ob5 159 5 ein ein NNP cord-006856-b1w25ob5 159 6 schwerwiegendes schwerwiegende NNS cord-006856-b1w25ob5 159 7 Problem Problem NNP cord-006856-b1w25ob5 159 8 nach nach NNP cord-006856-b1w25ob5 159 9 Lungentransplantation Lungentransplantation NNP cord-006856-b1w25ob5 159 10 dar dar NNP cord-006856-b1w25ob5 159 11 . . . cord-006856-b1w25ob5 160 1 Ziel Ziel NNP cord-006856-b1w25ob5 160 2 dieser dieser NNP cord-006856-b1w25ob5 160 3 Untersuchung Untersuchung NNP cord-006856-b1w25ob5 160 4 war war NN cord-006856-b1w25ob5 160 5 , , , cord-006856-b1w25ob5 160 6 den den NNP cord-006856-b1w25ob5 160 7 Einfluss Einfluss NNP cord-006856-b1w25ob5 160 8 der der NNP cord-006856-b1w25ob5 160 9 CMV CMV NNP cord-006856-b1w25ob5 160 10 - - HYPH cord-006856-b1w25ob5 160 11 Kombinationsprophylaxe Kombinationsprophylaxe NNP cord-006856-b1w25ob5 160 12 mittels mittel NNS cord-006856-b1w25ob5 160 13 Ganciclovir Ganciclovir NNP cord-006856-b1w25ob5 160 14 und und IN cord-006856-b1w25ob5 160 15 CMV CMV NNP cord-006856-b1w25ob5 160 16 - - HYPH cord-006856-b1w25ob5 160 17 Hyperimmunglobulinen Hyperimmunglobulinen NNP cord-006856-b1w25ob5 160 18 ( ( -LRB- cord-006856-b1w25ob5 160 19 CMV CMV NNP cord-006856-b1w25ob5 160 20 - - HYPH cord-006856-b1w25ob5 160 21 IG IG NNP cord-006856-b1w25ob5 160 22 ) ) -RRB- cord-006856-b1w25ob5 161 1 bezüglich bezüglich NNP cord-006856-b1w25ob5 161 2 Patientenüberleben Patientenüberleben NNP cord-006856-b1w25ob5 161 3 , , , cord-006856-b1w25ob5 161 4 CMV CMV NNP cord-006856-b1w25ob5 161 5 - - HYPH cord-006856-b1w25ob5 161 6 Reaktivierung Reaktivierung NNP cord-006856-b1w25ob5 161 7 , , , cord-006856-b1w25ob5 162 1 klinischer klinischer NNP cord-006856-b1w25ob5 162 2 CMV CMV NNP cord-006856-b1w25ob5 162 3 - - HYPH cord-006856-b1w25ob5 162 4 Erkrankung Erkrankung NNP cord-006856-b1w25ob5 162 5 und und XX cord-006856-b1w25ob5 163 1 Entwicklung Entwicklung NNP cord-006856-b1w25ob5 163 2 der der NNP cord-006856-b1w25ob5 163 3 Bronchiolitis Bronchiolitis NNP cord-006856-b1w25ob5 163 4 obliterans obliterans NN cord-006856-b1w25ob5 163 5 ( ( -LRB- cord-006856-b1w25ob5 163 6 BOS BOS NNP cord-006856-b1w25ob5 163 7 ) ) -RRB- cord-006856-b1w25ob5 163 8 zu zu NNP cord-006856-b1w25ob5 163 9 evaluieren evaluieren NNP cord-006856-b1w25ob5 163 10 . . . cord-006856-b1w25ob5 164 1 Methodik Methodik NNP cord-006856-b1w25ob5 164 2 . . . cord-006856-b1w25ob5 165 1 Eine Eine NNP cord-006856-b1w25ob5 165 2 konsekutive konsekutive FW cord-006856-b1w25ob5 165 3 Serie Serie NNP cord-006856-b1w25ob5 165 4 von von NNP cord-006856-b1w25ob5 165 5 68 68 CD cord-006856-b1w25ob5 166 1 CMV CMV NNP cord-006856-b1w25ob5 166 2 - - HYPH cord-006856-b1w25ob5 166 3 Hochrisikopatienten Hochrisikopatienten NNP cord-006856-b1w25ob5 166 4 ( ( -LRB- cord-006856-b1w25ob5 166 5 D+/R- D+/R- NNP cord-006856-b1w25ob5 166 6 , , , cord-006856-b1w25ob5 166 7 D+/R+ D+/R+ NNP cord-006856-b1w25ob5 166 8 ) ) -RRB- cord-006856-b1w25ob5 167 1 mit mit NNP cord-006856-b1w25ob5 167 2 einem einem NNP cord-006856-b1w25ob5 167 3 minimalen minimalen NNP cord-006856-b1w25ob5 167 4 Followup Followup NNP cord-006856-b1w25ob5 167 5 von von NNP cord-006856-b1w25ob5 167 6 mindestens mindestens NNP cord-006856-b1w25ob5 168 1 1 1 LS cord-006856-b1w25ob5 168 2 Jahr Jahr NNP cord-006856-b1w25ob5 168 3 post post JJ cord-006856-b1w25ob5 168 4 - - JJ cord-006856-b1w25ob5 168 5 transplant transplant JJ cord-006856-b1w25ob5 168 6 wurden wurden NNP cord-006856-b1w25ob5 168 7 analysiert analysiert NNP cord-006856-b1w25ob5 168 8 . . . cord-006856-b1w25ob5 169 1 Dreißig Dreißig NNP cord-006856-b1w25ob5 169 2 Patienten Patienten NNP cord-006856-b1w25ob5 169 3 ( ( -LRB- cord-006856-b1w25ob5 169 4 44,1 44,1 CD cord-006856-b1w25ob5 169 5 % % NN cord-006856-b1w25ob5 169 6 ) ) -RRB- cord-006856-b1w25ob5 169 7 erhielten erhielten NNP cord-006856-b1w25ob5 169 8 eine eine NNP cord-006856-b1w25ob5 170 1 alleinige alleinige NNP cord-006856-b1w25ob5 170 2 Ganciclovir Ganciclovir NNP cord-006856-b1w25ob5 170 3 - - HYPH cord-006856-b1w25ob5 170 4 Prophylaxe Prophylaxe NNP cord-006856-b1w25ob5 170 5 für für NNP cord-006856-b1w25ob5 170 6 3 3 CD cord-006856-b1w25ob5 170 7 Monate Monate NNP cord-006856-b1w25ob5 170 8 ( ( -LRB- cord-006856-b1w25ob5 170 9 Kontrollgruppe Kontrollgruppe NNP cord-006856-b1w25ob5 170 10 ) ) -RRB- cord-006856-b1w25ob5 170 11 , , . cord-006856-b1w25ob5 171 1 38 38 CD cord-006856-b1w25ob5 171 2 Transplantationsempfänger Transplantationsempfänger NNP cord-006856-b1w25ob5 171 3 ( ( -LRB- cord-006856-b1w25ob5 171 4 55,9 55,9 CD cord-006856-b1w25ob5 171 5 % % NN cord-006856-b1w25ob5 171 6 ) ) -RRB- cord-006856-b1w25ob5 171 7 erhielten erhielten NNP cord-006856-b1w25ob5 171 8 eine eine NNP cord-006856-b1w25ob5 171 9 zusätzliche zusätzliche NNP cord-006856-b1w25ob5 172 1 Prophylaxe Prophylaxe NNP cord-006856-b1w25ob5 172 2 mit mit XX cord-006856-b1w25ob5 173 1 CMV CMV NNP cord-006856-b1w25ob5 173 2 - - HYPH cord-006856-b1w25ob5 173 3 IG IG NNP cord-006856-b1w25ob5 173 4 ( ( -LRB- cord-006856-b1w25ob5 173 5 Cytotect Cytotect NNP cord-006856-b1w25ob5 173 6 ® ® POS cord-006856-b1w25ob5 173 7 , , , cord-006856-b1w25ob5 173 8 Biotest Biotest NNP cord-006856-b1w25ob5 173 9 Pharma Pharma NNP cord-006856-b1w25ob5 173 10 ) ) -RRB- cord-006856-b1w25ob5 173 11 in in IN cord-006856-b1w25ob5 173 12 5 5 CD cord-006856-b1w25ob5 173 13 Dosen Dosen NNP cord-006856-b1w25ob5 173 14 während während NNP cord-006856-b1w25ob5 173 15 des des NNP cord-006856-b1w25ob5 173 16 1 1 CD cord-006856-b1w25ob5 173 17 . . . cord-006856-b1w25ob5 174 1 postoperativen postoperativen NNP cord-006856-b1w25ob5 174 2 Monats Monats NNP cord-006856-b1w25ob5 174 3 ( ( -LRB- cord-006856-b1w25ob5 174 4 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 174 5 ) ) -RRB- cord-006856-b1w25ob5 174 6 . . . cord-006856-b1w25ob5 175 1 Das Das NNP cord-006856-b1w25ob5 175 2 mediane mediane NNP cord-006856-b1w25ob5 176 1 Follow follow VB cord-006856-b1w25ob5 176 2 - - HYPH cord-006856-b1w25ob5 176 3 up up RP cord-006856-b1w25ob5 176 4 betrug betrug NNP cord-006856-b1w25ob5 176 5 16,5 16,5 CD cord-006856-b1w25ob5 177 1 Monate Monate NNP cord-006856-b1w25ob5 177 2 in in IN cord-006856-b1w25ob5 177 3 der der NNP cord-006856-b1w25ob5 177 4 Kontrollgruppe Kontrollgruppe NNP cord-006856-b1w25ob5 177 5 und und XX cord-006856-b1w25ob5 178 1 23,8 23,8 CD cord-006856-b1w25ob5 178 2 Monate Monate NNP cord-006856-b1w25ob5 178 3 in in IN cord-006856-b1w25ob5 178 4 der der NNP cord-006856-b1w25ob5 178 5 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 178 6 ( ( -LRB- cord-006856-b1w25ob5 178 7 P p NN cord-006856-b1w25ob5 178 8 = = SYM cord-006856-b1w25ob5 178 9 0,54 0,54 CD cord-006856-b1w25ob5 178 10 ) ) -RRB- cord-006856-b1w25ob5 178 11 . . . cord-006856-b1w25ob5 179 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 179 2 . . . cord-006856-b1w25ob5 180 1 Insgesamt Insgesamt NNP cord-006856-b1w25ob5 180 2 5 5 CD cord-006856-b1w25ob5 180 3 CMV CMV NNP cord-006856-b1w25ob5 180 4 - - HYPH cord-006856-b1w25ob5 180 5 assoziierte assoziierte NNS cord-006856-b1w25ob5 180 6 Todesfälle Todesfälle NNP cord-006856-b1w25ob5 180 7 ( ( -LRB- cord-006856-b1w25ob5 180 8 16,7 16,7 CD cord-006856-b1w25ob5 180 9 % % NN cord-006856-b1w25ob5 180 10 ) ) -RRB- cord-006856-b1w25ob5 181 1 ereigneten ereigneten NNP cord-006856-b1w25ob5 181 2 sich sich NNP cord-006856-b1w25ob5 181 3 in in IN cord-006856-b1w25ob5 181 4 der der NNP cord-006856-b1w25ob5 181 5 Kontrollgruppe Kontrollgruppe NNP cord-006856-b1w25ob5 181 6 , , , cord-006856-b1w25ob5 181 7 jedoch jedoch NNP cord-006856-b1w25ob5 181 8 keiner keiner NNP cord-006856-b1w25ob5 181 9 in in IN cord-006856-b1w25ob5 181 10 der der NNP cord-006856-b1w25ob5 181 11 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 181 12 ( ( -LRB- cord-006856-b1w25ob5 181 13 P p NN cord-006856-b1w25ob5 181 14 = = SYM cord-006856-b1w25ob5 181 15 0,014 0,014 CD cord-006856-b1w25ob5 181 16 ) ) -RRB- cord-006856-b1w25ob5 181 17 . . . cord-006856-b1w25ob5 182 1 In in IN cord-006856-b1w25ob5 182 2 der der NNP cord-006856-b1w25ob5 182 3 Kontrollgruppe Kontrollgruppe NNP cord-006856-b1w25ob5 182 4 wurden wurden VBD cord-006856-b1w25ob5 182 5 13 13 CD cord-006856-b1w25ob5 182 6 Fälle Fälle NNP cord-006856-b1w25ob5 182 7 mit mit NNP cord-006856-b1w25ob5 182 8 klinischer klinischer NNP cord-006856-b1w25ob5 182 9 CMV CMV NNP cord-006856-b1w25ob5 182 10 - - HYPH cord-006856-b1w25ob5 182 11 Erkrankung Erkrankung NNP cord-006856-b1w25ob5 182 12 beobachtet beobachtet NNP cord-006856-b1w25ob5 182 13 ( ( -LRB- cord-006856-b1w25ob5 182 14 43,3 43,3 CD cord-006856-b1w25ob5 182 15 % % NN cord-006856-b1w25ob5 182 16 ) ) -RRB- cord-006856-b1w25ob5 182 17 , , , cord-006856-b1w25ob5 182 18 in in IN cord-006856-b1w25ob5 182 19 der der NNP cord-006856-b1w25ob5 182 20 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 182 21 5 5 CD cord-006856-b1w25ob5 183 1 Patienten Patienten NNP cord-006856-b1w25ob5 183 2 ( ( -LRB- cord-006856-b1w25ob5 183 3 13,2 13,2 CD cord-006856-b1w25ob5 183 4 % % NN cord-006856-b1w25ob5 183 5 ) ) -RRB- cord-006856-b1w25ob5 184 1 ( ( -LRB- cord-006856-b1w25ob5 184 2 P p NN cord-006856-b1w25ob5 184 3 = = SYM cord-006856-b1w25ob5 184 4 0,007 0,007 CD cord-006856-b1w25ob5 184 5 ) ) -RRB- cord-006856-b1w25ob5 184 6 . . . cord-006856-b1w25ob5 185 1 Zusätzlich Zusätzlich NNP cord-006856-b1w25ob5 185 2 zeigte zeigte NNP cord-006856-b1w25ob5 185 3 sich sich NNP cord-006856-b1w25ob5 185 4 ein ein NNP cord-006856-b1w25ob5 185 5 signifikant signifikant NN cord-006856-b1w25ob5 185 6 verbessertes verbessertes FW cord-006856-b1w25ob5 185 7 Patientenüberleben Patientenüberleben NNP cord-006856-b1w25ob5 185 8 in in IN cord-006856-b1w25ob5 185 9 der der NNP cord-006856-b1w25ob5 185 10 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 185 11 ( ( -LRB- cord-006856-b1w25ob5 186 1 log log NN cord-006856-b1w25ob5 186 2 - - HYPH cord-006856-b1w25ob5 186 3 rank rank NN cord-006856-b1w25ob5 186 4 , , , cord-006856-b1w25ob5 186 5 P p NN cord-006856-b1w25ob5 186 6 = = SYM cord-006856-b1w25ob5 186 7 0,01 0,01 NN cord-006856-b1w25ob5 186 8 ) ) -RRB- cord-006856-b1w25ob5 186 9 . . . cord-006856-b1w25ob5 187 1 Die die VB cord-006856-b1w25ob5 187 2 1-Jahresfreiheit 1-jahresfreiheit CD cord-006856-b1w25ob5 187 3 von von NNP cord-006856-b1w25ob5 188 1 CMV CMV NNP cord-006856-b1w25ob5 188 2 - - HYPH cord-006856-b1w25ob5 188 3 Reaktivierungen Reaktivierungen NNP cord-006856-b1w25ob5 188 4 betrug betrug NNP cord-006856-b1w25ob5 188 5 52,1 52,1 CD cord-006856-b1w25ob5 188 6 % % NN cord-006856-b1w25ob5 188 7 in in IN cord-006856-b1w25ob5 188 8 der der NNP cord-006856-b1w25ob5 188 9 Kontrollgruppe Kontrollgruppe NNP cord-006856-b1w25ob5 188 10 und und XX cord-006856-b1w25ob5 189 1 71,5 71,5 CD cord-006856-b1w25ob5 189 2 % % NN cord-006856-b1w25ob5 189 3 in in IN cord-006856-b1w25ob5 189 4 der der NNP cord-006856-b1w25ob5 189 5 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 189 6 ( ( -LRB- cord-006856-b1w25ob5 189 7 logrank logrank NNP cord-006856-b1w25ob5 189 8 , , , cord-006856-b1w25ob5 189 9 P p NN cord-006856-b1w25ob5 189 10 = = SYM cord-006856-b1w25ob5 189 11 0,027 0,027 CD cord-006856-b1w25ob5 189 12 ) ) -RRB- cord-006856-b1w25ob5 189 13 . . . cord-006856-b1w25ob5 190 1 Die die VB cord-006856-b1w25ob5 190 2 3-Jahresfreiheit 3-Jahresfreiheit NNP cord-006856-b1w25ob5 190 3 von von NNP cord-006856-b1w25ob5 190 4 BOS BOS NNP cord-006856-b1w25ob5 190 5 war war NN cord-006856-b1w25ob5 190 6 signifikant signifikant NN cord-006856-b1w25ob5 190 7 höher höher RBR cord-006856-b1w25ob5 190 8 in in IN cord-006856-b1w25ob5 190 9 der der NNP cord-006856-b1w25ob5 190 10 Studiengruppe Studiengruppe NNP cord-006856-b1w25ob5 190 11 ( ( -LRB- cord-006856-b1w25ob5 190 12 54,3 54,3 CD cord-006856-b1w25ob5 190 13 % % NN cord-006856-b1w25ob5 190 14 vs. vs. IN cord-006856-b1w25ob5 190 15 82 82 CD cord-006856-b1w25ob5 190 16 % % NN cord-006856-b1w25ob5 190 17 , , , cord-006856-b1w25ob5 190 18 log log NN cord-006856-b1w25ob5 190 19 - - HYPH cord-006856-b1w25ob5 190 20 rank rank NN cord-006856-b1w25ob5 190 21 , , , cord-006856-b1w25ob5 190 22 P p NN cord-006856-b1w25ob5 190 23 = = SYM cord-006856-b1w25ob5 190 24 0,024 0,024 CD cord-006856-b1w25ob5 190 25 ) ) -RRB- cord-006856-b1w25ob5 190 26 . . . cord-006856-b1w25ob5 191 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 191 2 . . . cord-006856-b1w25ob5 192 1 Eine eine JJ cord-006856-b1w25ob5 192 2 zusätzliche zusätzliche NNP cord-006856-b1w25ob5 192 3 CMV CMV NNP cord-006856-b1w25ob5 192 4 - - HYPH cord-006856-b1w25ob5 192 5 Hyperimmunglobulinprophylaxe Hyperimmunglobulinprophylaxe NNP cord-006856-b1w25ob5 192 6 senkt senkt NNS cord-006856-b1w25ob5 192 7 die die VBP cord-006856-b1w25ob5 192 8 CMV CMV NNP cord-006856-b1w25ob5 192 9 - - HYPH cord-006856-b1w25ob5 192 10 assoziierte assoziierte NNS cord-006856-b1w25ob5 192 11 Morbidität Morbidität NNP cord-006856-b1w25ob5 192 12 und und IN cord-006856-b1w25ob5 192 13 Mortalität Mortalität NNP cord-006856-b1w25ob5 192 14 . . . cord-006856-b1w25ob5 193 1 Weiters Weiters NNP cord-006856-b1w25ob5 193 2 kann kann NNP cord-006856-b1w25ob5 193 3 das das NNP cord-006856-b1w25ob5 193 4 Auftreten Auftreten NNP cord-006856-b1w25ob5 193 5 der der NNP cord-006856-b1w25ob5 193 6 BOS BOS NNP cord-006856-b1w25ob5 193 7 mittels mittels NNP cord-006856-b1w25ob5 194 1 augmentierter augmentierter NNP cord-006856-b1w25ob5 194 2 CMV CMV NNP cord-006856-b1w25ob5 194 3 - - HYPH cord-006856-b1w25ob5 194 4 Prophylaxe Prophylaxe NNP cord-006856-b1w25ob5 194 5 reduziert reduziert NNP cord-006856-b1w25ob5 194 6 werden werden NNP cord-006856-b1w25ob5 194 7 . . . cord-006856-b1w25ob5 195 1 Durch Durch NNP cord-006856-b1w25ob5 195 2 die die VBP cord-006856-b1w25ob5 195 3 dadurch dadurch JJ cord-006856-b1w25ob5 195 4 reduzierte reduzierte NNS cord-006856-b1w25ob5 196 1 Morbidität Morbidität NNP cord-006856-b1w25ob5 196 2 ist ist NN cord-006856-b1w25ob5 196 3 die die VBP cord-006856-b1w25ob5 196 4 Kosteneffizienz Kosteneffizienz NNP cord-006856-b1w25ob5 196 5 gegeben gegeben NN cord-006856-b1w25ob5 196 6 . . . cord-006856-b1w25ob5 197 1 V13 v13 JJ cord-006856-b1w25ob5 197 2 Extracorporeal extracorporeal JJ cord-006856-b1w25ob5 197 3 photoimmune photoimmune NN cord-006856-b1w25ob5 197 4 therapy therapy NN cord-006856-b1w25ob5 197 5 ( ( -LRB- cord-006856-b1w25ob5 197 6 ECP ECP NNP cord-006856-b1w25ob5 197 7 ) ) -RRB- cord-006856-b1w25ob5 197 8 with with IN cord-006856-b1w25ob5 197 9 UVADEX UVADEX NNP cord-006856-b1w25ob5 197 10 in in IN cord-006856-b1w25ob5 197 11 conjunction conjunction NN cord-006856-b1w25ob5 197 12 with with IN cord-006856-b1w25ob5 197 13 standard standard JJ cord-006856-b1w25ob5 197 14 therapy therapy NN cord-006856-b1w25ob5 197 15 compared compare VBN cord-006856-b1w25ob5 197 16 to to IN cord-006856-b1w25ob5 197 17 standard standard JJ cord-006856-b1w25ob5 197 18 therapy therapy NN cord-006856-b1w25ob5 197 19 alone alone RB cord-006856-b1w25ob5 197 20 for for IN cord-006856-b1w25ob5 197 21 the the DT cord-006856-b1w25ob5 197 22 prevention prevention NN cord-006856-b1w25ob5 197 23 of of IN cord-006856-b1w25ob5 197 24 rejection rejection NN cord-006856-b1w25ob5 197 25 in in IN cord-006856-b1w25ob5 197 26 lung lung NN cord-006856-b1w25ob5 197 27 transplantation transplantation NN cord-006856-b1w25ob5 197 28 patients patient NNS cord-006856-b1w25ob5 197 29 P. P. NNP cord-006856-b1w25ob5 197 30 Jaksch Jaksch NNP cord-006856-b1w25ob5 197 31 , , , cord-006856-b1w25ob5 197 32 R. R. NNP cord-006856-b1w25ob5 197 33 Knobler Knobler NNP cord-006856-b1w25ob5 197 34 , , , cord-006856-b1w25ob5 197 35 B. B. NNP cord-006856-b1w25ob5 197 36 Schlechta Schlechta NNP cord-006856-b1w25ob5 197 37 , , , cord-006856-b1w25ob5 197 38 S. S. NNP cord-006856-b1w25ob5 197 39 Guth Guth NNP cord-006856-b1w25ob5 197 40 , , , cord-006856-b1w25ob5 197 41 W. W. NNP cord-006856-b1w25ob5 197 42 Klepetko Klepetko NNP cord-006856-b1w25ob5 197 43 Klinische Klinische NNP cord-006856-b1w25ob5 197 44 Abteilung Abteilung NNP cord-006856-b1w25ob5 197 45 für für IN cord-006856-b1w25ob5 197 46 Herz Herz NNP cord-006856-b1w25ob5 197 47 - - HYPH cord-006856-b1w25ob5 197 48 Thoraxchirurgie Thoraxchirurgie NNP cord-006856-b1w25ob5 197 49 , , , cord-006856-b1w25ob5 197 50 Universitätsklinik Universitätsklinik NNP cord-006856-b1w25ob5 197 51 für für IN cord-006856-b1w25ob5 197 52 Chirurgie Chirurgie NNP cord-006856-b1w25ob5 197 53 , , , cord-006856-b1w25ob5 198 1 Medizinische Medizinische NNP cord-006856-b1w25ob5 198 2 Universität Universität NNP cord-006856-b1w25ob5 198 3 Wien Wien NNP cord-006856-b1w25ob5 198 4 , , , cord-006856-b1w25ob5 198 5 Wien Wien NNP cord-006856-b1w25ob5 198 6 , , , cord-006856-b1w25ob5 198 7 Österreich Österreich NNP cord-006856-b1w25ob5 198 8 Background Background NNP cord-006856-b1w25ob5 198 9 . . . cord-006856-b1w25ob5 199 1 Extracorporeal extracorporeal JJ cord-006856-b1w25ob5 199 2 photopheresis photopheresis NN cord-006856-b1w25ob5 199 3 has have VBZ cord-006856-b1w25ob5 199 4 been be VBN cord-006856-b1w25ob5 199 5 shown show VBN cord-006856-b1w25ob5 199 6 to to TO cord-006856-b1w25ob5 199 7 be be VB cord-006856-b1w25ob5 199 8 beneficial beneficial JJ cord-006856-b1w25ob5 199 9 in in IN cord-006856-b1w25ob5 199 10 acute acute JJ cord-006856-b1w25ob5 199 11 and and CC cord-006856-b1w25ob5 199 12 chronic chronic JJ cord-006856-b1w25ob5 199 13 rejection rejection NN cord-006856-b1w25ob5 199 14 in in IN cord-006856-b1w25ob5 199 15 heart heart NN cord-006856-b1w25ob5 199 16 transplant transplant NN cord-006856-b1w25ob5 199 17 patients patient NNS cord-006856-b1w25ob5 199 18 and and CC cord-006856-b1w25ob5 199 19 has have VBZ cord-006856-b1w25ob5 199 20 also also RB cord-006856-b1w25ob5 199 21 been be VBN cord-006856-b1w25ob5 199 22 used use VBN cord-006856-b1w25ob5 199 23 in in IN cord-006856-b1w25ob5 199 24 lung lung NN cord-006856-b1w25ob5 199 25 transplant transplant NN cord-006856-b1w25ob5 199 26 recipients recipient NNS cord-006856-b1w25ob5 199 27 with with IN cord-006856-b1w25ob5 199 28 acute acute JJ cord-006856-b1w25ob5 199 29 rejection rejection NN cord-006856-b1w25ob5 199 30 or or CC cord-006856-b1w25ob5 199 31 bronchiolitis bronchiolitis NN cord-006856-b1w25ob5 199 32 obliterans obliterans NNP cord-006856-b1w25ob5 199 33 . . . cord-006856-b1w25ob5 200 1 Methods method NNS cord-006856-b1w25ob5 200 2 . . . cord-006856-b1w25ob5 201 1 We -PRON- PRP cord-006856-b1w25ob5 201 2 performed perform VBD cord-006856-b1w25ob5 201 3 a a DT cord-006856-b1w25ob5 201 4 prospective prospective JJ cord-006856-b1w25ob5 201 5 study study NN cord-006856-b1w25ob5 201 6 to to TO cord-006856-b1w25ob5 201 7 document document VB cord-006856-b1w25ob5 201 8 the the DT cord-006856-b1w25ob5 201 9 efficacy efficacy NN cord-006856-b1w25ob5 201 10 of of IN cord-006856-b1w25ob5 201 11 photoimmune photoimmune NNP cord-006856-b1w25ob5 201 12 therapy therapy NN cord-006856-b1w25ob5 201 13 in in IN cord-006856-b1w25ob5 201 14 the the DT cord-006856-b1w25ob5 201 15 prevention prevention NN cord-006856-b1w25ob5 201 16 of of IN cord-006856-b1w25ob5 201 17 acute acute JJ cord-006856-b1w25ob5 201 18 rejections rejection NNS cord-006856-b1w25ob5 201 19 in in IN cord-006856-b1w25ob5 201 20 the the DT cord-006856-b1w25ob5 201 21 first first JJ cord-006856-b1w25ob5 201 22 12 12 CD cord-006856-b1w25ob5 201 23 months month NNS cord-006856-b1w25ob5 201 24 after after IN cord-006856-b1w25ob5 201 25 lung lung NN cord-006856-b1w25ob5 201 26 transplantation transplantation NN cord-006856-b1w25ob5 201 27 . . . cord-006856-b1w25ob5 202 1 12 12 CD cord-006856-b1w25ob5 202 2 lung lung NN cord-006856-b1w25ob5 202 3 transplant transplant NN cord-006856-b1w25ob5 202 4 recipients recipient NNS cord-006856-b1w25ob5 202 5 with with IN cord-006856-b1w25ob5 202 6 COPD COPD NNP cord-006856-b1w25ob5 202 7 were be VBD cord-006856-b1w25ob5 202 8 randomized randomize VBN cord-006856-b1w25ob5 202 9 in in IN cord-006856-b1w25ob5 202 10 2 2 CD cord-006856-b1w25ob5 202 11 groups group NNS cord-006856-b1w25ob5 202 12 . . . cord-006856-b1w25ob5 203 1 Group Group NNP cord-006856-b1w25ob5 203 2 A A NNP cord-006856-b1w25ob5 203 3 ( ( -LRB- cord-006856-b1w25ob5 203 4 6 6 CD cord-006856-b1w25ob5 203 5 pat pat NN cord-006856-b1w25ob5 203 6 ) ) -RRB- cord-006856-b1w25ob5 203 7 received receive VBN cord-006856-b1w25ob5 203 8 in in IN cord-006856-b1w25ob5 203 9 total total JJ cord-006856-b1w25ob5 203 10 16 16 CD cord-006856-b1w25ob5 203 11 ECP ECP NNP cord-006856-b1w25ob5 203 12 treatments treatment NNS cord-006856-b1w25ob5 203 13 ( ( -LRB- cord-006856-b1w25ob5 203 14 starting start VBG cord-006856-b1w25ob5 203 15 2 2 CD cord-006856-b1w25ob5 203 16 weeks week NNS cord-006856-b1w25ob5 203 17 after after IN cord-006856-b1w25ob5 203 18 TX TX NNP cord-006856-b1w25ob5 203 19 ) ) -RRB- cord-006856-b1w25ob5 203 20 and and CC cord-006856-b1w25ob5 203 21 group group NN cord-006856-b1w25ob5 203 22 B B NNP cord-006856-b1w25ob5 203 23 without without IN cord-006856-b1w25ob5 203 24 ECP ECP NNP cord-006856-b1w25ob5 203 25 or or CC cord-006856-b1w25ob5 203 26 other other JJ cord-006856-b1w25ob5 203 27 kind kind NN cord-006856-b1w25ob5 203 28 of of IN cord-006856-b1w25ob5 203 29 induction induction NN cord-006856-b1w25ob5 203 30 therapy therapy NN cord-006856-b1w25ob5 203 31 , , , cord-006856-b1w25ob5 203 32 both both DT cord-006856-b1w25ob5 203 33 groups group NNS cord-006856-b1w25ob5 203 34 receiving receive VBG cord-006856-b1w25ob5 203 35 standard standard JJ cord-006856-b1w25ob5 203 36 triple triple JJ cord-006856-b1w25ob5 203 37 immunosuppression immunosuppression NN cord-006856-b1w25ob5 203 38 with with IN cord-006856-b1w25ob5 203 39 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 203 40 , , , cord-006856-b1w25ob5 203 41 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 203 42 , , , cord-006856-b1w25ob5 203 43 and and CC cord-006856-b1w25ob5 203 44 steroids steroid NNS cord-006856-b1w25ob5 203 45 . . . cord-006856-b1w25ob5 204 1 Surveillance surveillance NN cord-006856-b1w25ob5 204 2 bronchoscopies bronchoscopie NNS cord-006856-b1w25ob5 204 3 with with IN cord-006856-b1w25ob5 204 4 biopsies biopsy NNS cord-006856-b1w25ob5 204 5 were be VBD cord-006856-b1w25ob5 204 6 performed perform VBN cord-006856-b1w25ob5 204 7 after after IN cord-006856-b1w25ob5 204 8 2 2 CD cord-006856-b1w25ob5 204 9 , , , cord-006856-b1w25ob5 204 10 4 4 CD cord-006856-b1w25ob5 204 11 , , , cord-006856-b1w25ob5 204 12 8 8 CD cord-006856-b1w25ob5 204 13 , , , cord-006856-b1w25ob5 204 14 12 12 CD cord-006856-b1w25ob5 204 15 , , , cord-006856-b1w25ob5 204 16 26 26 CD cord-006856-b1w25ob5 204 17 , , , cord-006856-b1w25ob5 204 18 and and CC cord-006856-b1w25ob5 204 19 52 52 CD cord-006856-b1w25ob5 204 20 weeks week NNS cord-006856-b1w25ob5 204 21 . . . cord-006856-b1w25ob5 205 1 Primary primary JJ cord-006856-b1w25ob5 205 2 objectives objective NNS cord-006856-b1w25ob5 205 3 were be VBD cord-006856-b1w25ob5 205 4 acute acute JJ cord-006856-b1w25ob5 205 5 biopsy biopsy NN cord-006856-b1w25ob5 205 6 - - HYPH cord-006856-b1w25ob5 205 7 proven prove VBN cord-006856-b1w25ob5 205 8 rejections rejection NNS cord-006856-b1w25ob5 205 9 of of IN cord-006856-b1w25ob5 205 10 ISHLT ISHLT NNP cord-006856-b1w25ob5 205 11 grade grade NN cord-006856-b1w25ob5 205 12 > > XX cord-006856-b1w25ob5 205 13 1 1 CD cord-006856-b1w25ob5 205 14 , , , cord-006856-b1w25ob5 205 15 secondary secondary JJ cord-006856-b1w25ob5 205 16 objectives objective NNS cord-006856-b1w25ob5 205 17 were be VBD cord-006856-b1w25ob5 205 18 number number NN cord-006856-b1w25ob5 205 19 of of IN cord-006856-b1w25ob5 205 20 infections infection NNS cord-006856-b1w25ob5 205 21 ( ( -LRB- cord-006856-b1w25ob5 205 22 CMV CMV NNP cord-006856-b1w25ob5 205 23 , , , cord-006856-b1w25ob5 205 24 bacterial bacterial JJ cord-006856-b1w25ob5 205 25 , , , cord-006856-b1w25ob5 205 26 fungal fungal JJ cord-006856-b1w25ob5 205 27 , , , cord-006856-b1w25ob5 205 28 viral viral JJ cord-006856-b1w25ob5 205 29 non non JJ cord-006856-b1w25ob5 205 30 - - JJ cord-006856-b1w25ob5 205 31 CMV CMV NNP cord-006856-b1w25ob5 205 32 , , , cord-006856-b1w25ob5 205 33 tuberculosis tuberculosis NN cord-006856-b1w25ob5 205 34 , , , cord-006856-b1w25ob5 205 35 parasitic parasitic JJ cord-006856-b1w25ob5 205 36 ) ) -RRB- cord-006856-b1w25ob5 205 37 , , , cord-006856-b1w25ob5 205 38 patients patient NNS cord-006856-b1w25ob5 205 39 and and CC cord-006856-b1w25ob5 205 40 graft graft NN cord-006856-b1w25ob5 205 41 survival survival NN cord-006856-b1w25ob5 205 42 . . . cord-006856-b1w25ob5 206 1 Results result NNS cord-006856-b1w25ob5 206 2 . . . cord-006856-b1w25ob5 207 1 Demographics demographic NNS cord-006856-b1w25ob5 207 2 in in IN cord-006856-b1w25ob5 207 3 both both DT cord-006856-b1w25ob5 207 4 groups group NNS cord-006856-b1w25ob5 207 5 were be VBD cord-006856-b1w25ob5 207 6 similar similar JJ cord-006856-b1w25ob5 207 7 ( ( -LRB- cord-006856-b1w25ob5 207 8 gender gender NN cord-006856-b1w25ob5 207 9 , , , cord-006856-b1w25ob5 207 10 age age NN cord-006856-b1w25ob5 207 11 , , , cord-006856-b1w25ob5 207 12 underlying underlie VBG cord-006856-b1w25ob5 207 13 disease disease NN cord-006856-b1w25ob5 207 14 , , , cord-006856-b1w25ob5 207 15 CMV CMV NNP cord-006856-b1w25ob5 207 16 mismatch mismatch NN cord-006856-b1w25ob5 207 17 , , , cord-006856-b1w25ob5 207 18 and and CC cord-006856-b1w25ob5 207 19 type type NN cord-006856-b1w25ob5 207 20 of of IN cord-006856-b1w25ob5 207 21 TX TX NNP cord-006856-b1w25ob5 207 22 ) ) -RRB- cord-006856-b1w25ob5 207 23 . . . cord-006856-b1w25ob5 208 1 FEV FEV NNP cord-006856-b1w25ob5 208 2 1 1 CD cord-006856-b1w25ob5 208 3 % % NN cord-006856-b1w25ob5 208 4 and and CC cord-006856-b1w25ob5 208 5 MEF MEF NNP cord-006856-b1w25ob5 208 6 50 50 CD cord-006856-b1w25ob5 208 7 % % NN cord-006856-b1w25ob5 208 8 values value NNS cord-006856-b1w25ob5 208 9 after after IN cord-006856-b1w25ob5 208 10 1 1 CD cord-006856-b1w25ob5 208 11 year year NN cord-006856-b1w25ob5 208 12 were be VBD cord-006856-b1w25ob5 208 13 equal equal JJ cord-006856-b1w25ob5 208 14 ( ( -LRB- cord-006856-b1w25ob5 208 15 88.3 88.3 CD cord-006856-b1w25ob5 208 16 ± ± CD cord-006856-b1w25ob5 208 17 7.9 7.9 CD cord-006856-b1w25ob5 208 18 % % NN cord-006856-b1w25ob5 208 19 vs. vs. NN cord-006856-b1w25ob5 208 20 90 90 CD cord-006856-b1w25ob5 209 1 ± ± NNP cord-006856-b1w25ob5 209 2 28 28 CD cord-006856-b1w25ob5 209 3 . . . cord-006856-b1w25ob5 210 1 1 1 CD cord-006856-b1w25ob5 210 2 and and CC cord-006856-b1w25ob5 210 3 113.5 113.5 CD cord-006856-b1w25ob5 210 4 ± ± CD cord-006856-b1w25ob5 210 5 41.7 41.7 CD cord-006856-b1w25ob5 210 6 % % NN cord-006856-b1w25ob5 210 7 vs. vs. IN cord-006856-b1w25ob5 210 8 114.5 114.5 CD cord-006856-b1w25ob5 210 9 ± ± CD cord-006856-b1w25ob5 210 10 42.2 42.2 CD cord-006856-b1w25ob5 210 11 % % NN cord-006856-b1w25ob5 210 12 , , , cord-006856-b1w25ob5 210 13 respectively respectively RB cord-006856-b1w25ob5 210 14 ) ) -RRB- cord-006856-b1w25ob5 210 15 . . . cord-006856-b1w25ob5 211 1 The the DT cord-006856-b1w25ob5 211 2 number number NN cord-006856-b1w25ob5 211 3 of of IN cord-006856-b1w25ob5 211 4 rejections rejection NNS cord-006856-b1w25ob5 211 5 in in IN cord-006856-b1w25ob5 211 6 group group NN cord-006856-b1w25ob5 211 7 A A NNP cord-006856-b1w25ob5 211 8 ( ( -LRB- cord-006856-b1w25ob5 211 9 with with IN cord-006856-b1w25ob5 211 10 ECP ECP NNP cord-006856-b1w25ob5 211 11 ) ) -RRB- cord-006856-b1w25ob5 211 12 was be VBD cord-006856-b1w25ob5 211 13 lower low JJR cord-006856-b1w25ob5 211 14 than than IN cord-006856-b1w25ob5 211 15 in in IN cord-006856-b1w25ob5 211 16 group group NN cord-006856-b1w25ob5 211 17 B b NN cord-006856-b1w25ob5 211 18 ( ( -LRB- cord-006856-b1w25ob5 211 19 0.17 0.17 CD cord-006856-b1w25ob5 211 20 ± ± CD cord-006856-b1w25ob5 211 21 0.41 0.41 CD cord-006856-b1w25ob5 211 22 vs. vs. NN cord-006856-b1w25ob5 211 23 0.83 0.83 CD cord-006856-b1w25ob5 211 24 ± ± CD cord-006856-b1w25ob5 211 25 0.75 0.75 CD cord-006856-b1w25ob5 211 26 , , , cord-006856-b1w25ob5 211 27 P p NN cord-006856-b1w25ob5 211 28 = = SYM cord-006856-b1w25ob5 211 29 0.094 0.094 CD cord-006856-b1w25ob5 211 30 ) ) -RRB- cord-006856-b1w25ob5 211 31 , , , cord-006856-b1w25ob5 211 32 as as RB cord-006856-b1w25ob5 211 33 well well RB cord-006856-b1w25ob5 211 34 as as IN cord-006856-b1w25ob5 211 35 the the DT cord-006856-b1w25ob5 211 36 median median JJ cord-006856-b1w25ob5 211 37 rejection rejection NN cord-006856-b1w25ob5 211 38 grade grade NN cord-006856-b1w25ob5 211 39 ( ( -LRB- cord-006856-b1w25ob5 211 40 0.16 0.16 CD cord-006856-b1w25ob5 211 41 ± ± NNP cord-006856-b1w25ob5 211 42 0.4 0.4 CD cord-006856-b1w25ob5 211 43 for for IN cord-006856-b1w25ob5 211 44 group group NN cord-006856-b1w25ob5 211 45 A a NN cord-006856-b1w25ob5 211 46 vs. vs. NN cord-006856-b1w25ob5 211 47 0.66 0.66 CD cord-006856-b1w25ob5 211 48 ± ± CD cord-006856-b1w25ob5 211 49 0.51 0.51 CD cord-006856-b1w25ob5 211 50 for for IN cord-006856-b1w25ob5 211 51 group group NN cord-006856-b1w25ob5 211 52 B B NNP cord-006856-b1w25ob5 211 53 , , , cord-006856-b1w25ob5 211 54 P p NN cord-006856-b1w25ob5 211 55 = = SYM cord-006856-b1w25ob5 211 56 0.092 0.092 CD cord-006856-b1w25ob5 211 57 ) ) -RRB- cord-006856-b1w25ob5 211 58 . . . cord-006856-b1w25ob5 212 1 After after IN cord-006856-b1w25ob5 212 2 one one CD cord-006856-b1w25ob5 212 3 year year NN cord-006856-b1w25ob5 212 4 post post NN cord-006856-b1w25ob5 212 5 TX TX NNP cord-006856-b1w25ob5 212 6 , , , cord-006856-b1w25ob5 212 7 all all DT cord-006856-b1w25ob5 212 8 patients patient NNS cord-006856-b1w25ob5 212 9 are be VBP cord-006856-b1w25ob5 212 10 alive alive JJ cord-006856-b1w25ob5 212 11 , , , cord-006856-b1w25ob5 212 12 none none NN cord-006856-b1w25ob5 212 13 developed develop VBD cord-006856-b1w25ob5 212 14 BO(S bo(s NN cord-006856-b1w25ob5 212 15 ) ) -RRB- cord-006856-b1w25ob5 213 1 within within IN cord-006856-b1w25ob5 213 2 the the DT cord-006856-b1w25ob5 213 3 first first JJ cord-006856-b1w25ob5 213 4 year year NN cord-006856-b1w25ob5 213 5 post post NN cord-006856-b1w25ob5 213 6 TX TX NNP cord-006856-b1w25ob5 213 7 . . . cord-006856-b1w25ob5 214 1 Conclusions conclusion NNS cord-006856-b1w25ob5 214 2 . . . cord-006856-b1w25ob5 215 1 Our -PRON- PRP$ cord-006856-b1w25ob5 215 2 preliminary preliminary JJ cord-006856-b1w25ob5 215 3 data datum NNS cord-006856-b1w25ob5 215 4 show show VBP cord-006856-b1w25ob5 215 5 a a DT cord-006856-b1w25ob5 215 6 clear clear JJ cord-006856-b1w25ob5 215 7 trend trend NN cord-006856-b1w25ob5 215 8 towards towards IN cord-006856-b1w25ob5 215 9 reducing reduce VBG cord-006856-b1w25ob5 215 10 the the DT cord-006856-b1w25ob5 215 11 number number NN cord-006856-b1w25ob5 215 12 and and CC cord-006856-b1w25ob5 215 13 severity severity NN cord-006856-b1w25ob5 215 14 of of IN cord-006856-b1w25ob5 215 15 acute acute JJ cord-006856-b1w25ob5 215 16 rejections rejection NNS cord-006856-b1w25ob5 215 17 in in IN cord-006856-b1w25ob5 215 18 lung lung NN cord-006856-b1w25ob5 215 19 transplant transplant NN cord-006856-b1w25ob5 215 20 recipients recipient NNS cord-006856-b1w25ob5 215 21 . . . cord-006856-b1w25ob5 216 1 The the DT cord-006856-b1w25ob5 216 2 number number NN cord-006856-b1w25ob5 216 3 of of IN cord-006856-b1w25ob5 216 4 infections infection NNS cord-006856-b1w25ob5 216 5 was be VBD cord-006856-b1w25ob5 216 6 similar similar JJ cord-006856-b1w25ob5 216 7 in in IN cord-006856-b1w25ob5 216 8 both both DT cord-006856-b1w25ob5 216 9 groups group NNS cord-006856-b1w25ob5 216 10 . . . cord-006856-b1w25ob5 217 1 Adding add VBG cord-006856-b1w25ob5 217 2 ECP ECP NNP cord-006856-b1w25ob5 217 3 to to IN cord-006856-b1w25ob5 217 4 a a DT cord-006856-b1w25ob5 217 5 standard standard JJ cord-006856-b1w25ob5 217 6 triple triple JJ cord-006856-b1w25ob5 217 7 - - HYPH cord-006856-b1w25ob5 217 8 drug drug NN cord-006856-b1w25ob5 217 9 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 217 10 regimen regimen NN cord-006856-b1w25ob5 217 11 seems seem VBZ cord-006856-b1w25ob5 217 12 to to TO cord-006856-b1w25ob5 217 13 be be VB cord-006856-b1w25ob5 217 14 a a DT cord-006856-b1w25ob5 217 15 safe safe JJ cord-006856-b1w25ob5 217 16 and and CC cord-006856-b1w25ob5 217 17 efficient efficient JJ cord-006856-b1w25ob5 217 18 tool tool NN cord-006856-b1w25ob5 217 19 in in IN cord-006856-b1w25ob5 217 20 reducing reduce VBG cord-006856-b1w25ob5 217 21 rejection rejection NN cord-006856-b1w25ob5 217 22 rates rate NNS cord-006856-b1w25ob5 217 23 without without IN cord-006856-b1w25ob5 217 24 increasing increase VBG cord-006856-b1w25ob5 217 25 the the DT cord-006856-b1w25ob5 217 26 rate rate NN cord-006856-b1w25ob5 217 27 of of IN cord-006856-b1w25ob5 217 28 bacterial bacterial JJ cord-006856-b1w25ob5 217 29 , , , cord-006856-b1w25ob5 217 30 fungal fungal JJ cord-006856-b1w25ob5 217 31 , , , cord-006856-b1w25ob5 217 32 or or CC cord-006856-b1w25ob5 217 33 viral viral JJ cord-006856-b1w25ob5 217 34 infection infection NN cord-006856-b1w25ob5 217 35 . . . cord-006856-b1w25ob5 218 1 Grundlagen Grundlagen NNP cord-006856-b1w25ob5 218 2 . . . cord-006856-b1w25ob5 219 1 Erhöhte Erhöhte NNP cord-006856-b1w25ob5 219 2 Natriumspiegel Natriumspiegel NNP cord-006856-b1w25ob5 219 3 bei bei NNP cord-006856-b1w25ob5 219 4 Organspendern Organspendern NNP cord-006856-b1w25ob5 220 1 können können UH cord-006856-b1w25ob5 220 2 mit mit NNP cord-006856-b1w25ob5 220 3 der der NNP cord-006856-b1w25ob5 220 4 Bildung Bildung NNP cord-006856-b1w25ob5 220 5 von von NNP cord-006856-b1w25ob5 220 6 Reperfusionsödemen Reperfusionsödemen NNP cord-006856-b1w25ob5 220 7 und und IN cord-006856-b1w25ob5 220 8 Transplantatdysfunktion Transplantatdysfunktion NNP cord-006856-b1w25ob5 220 9 assoziiert assoziiert NNP cord-006856-b1w25ob5 220 10 sein sein NNP cord-006856-b1w25ob5 220 11 . . . cord-006856-b1w25ob5 221 1 Unklarheit Unklarheit NNP cord-006856-b1w25ob5 221 2 besteht besteht NNP cord-006856-b1w25ob5 221 3 allerdings allerdings NNP cord-006856-b1w25ob5 221 4 über über NNP cord-006856-b1w25ob5 221 5 die die VBP cord-006856-b1w25ob5 222 1 klinischen klinischen NNP cord-006856-b1w25ob5 222 2 Auswirkungen Auswirkungen NNP cord-006856-b1w25ob5 222 3 von von NNP cord-006856-b1w25ob5 222 4 erhöhtem erhöhtem NNP cord-006856-b1w25ob5 222 5 Spender Spender NNP cord-006856-b1w25ob5 222 6 - - HYPH cord-006856-b1w25ob5 222 7 Natrium Natrium NNP cord-006856-b1w25ob5 222 8 nach nach NN cord-006856-b1w25ob5 222 9 Herztransplantation Herztransplantation NNP cord-006856-b1w25ob5 222 10 ( ( -LRB- cord-006856-b1w25ob5 222 11 HTX HTX NNP cord-006856-b1w25ob5 222 12 ) ) -RRB- cord-006856-b1w25ob5 222 13 . . . cord-006856-b1w25ob5 223 1 In in IN cord-006856-b1w25ob5 223 2 dieser dieser NNP cord-006856-b1w25ob5 223 3 Studie Studie NNP cord-006856-b1w25ob5 223 4 wurde wurde NNP cord-006856-b1w25ob5 223 5 der der NNP cord-006856-b1w25ob5 223 6 Einfluss Einfluss NNP cord-006856-b1w25ob5 223 7 von von VBP cord-006856-b1w25ob5 223 8 hohem hohem NNP cord-006856-b1w25ob5 223 9 Spender Spender NNP cord-006856-b1w25ob5 223 10 - - HYPH cord-006856-b1w25ob5 223 11 Natrium Natrium NNP cord-006856-b1w25ob5 223 12 auf auf NNS cord-006856-b1w25ob5 223 13 die die VBP cord-006856-b1w25ob5 223 14 Frühund Frühund NNP cord-006856-b1w25ob5 223 15 1-Jahresmortalität 1-jahresmortalität CD cord-006856-b1w25ob5 224 1 nach nach NNP cord-006856-b1w25ob5 224 2 HTX HTX NNP cord-006856-b1w25ob5 224 3 in in IN cord-006856-b1w25ob5 224 4 einem einem NNP cord-006856-b1w25ob5 224 5 großen großen NNP cord-006856-b1w25ob5 224 6 Patientenkollektiv Patientenkollektiv NNP cord-006856-b1w25ob5 224 7 analysiert analysiert NN cord-006856-b1w25ob5 224 8 . . . cord-006856-b1w25ob5 225 1 Methodik Methodik NNP cord-006856-b1w25ob5 225 2 . . . cord-006856-b1w25ob5 226 1 Es Es NNP cord-006856-b1w25ob5 226 2 wurden wurden NNS cord-006856-b1w25ob5 226 3 3157 3157 CD cord-006856-b1w25ob5 226 4 Herztransplantationen Herztransplantationen NNP cord-006856-b1w25ob5 226 5 der der NNP cord-006856-b1w25ob5 226 6 Eurotransplant Eurotransplant NNP cord-006856-b1w25ob5 226 7 - - HYPH cord-006856-b1w25ob5 226 8 Region Region NNP cord-006856-b1w25ob5 226 9 aus aus NNP cord-006856-b1w25ob5 226 10 dem dem NNP cord-006856-b1w25ob5 226 11 Zeitraum Zeitraum NNP cord-006856-b1w25ob5 226 12 Jänner Jänner NNP cord-006856-b1w25ob5 226 13 1997 1997 CD cord-006856-b1w25ob5 227 1 bis bis NNP cord-006856-b1w25ob5 227 2 Dezember Dezember NNP cord-006856-b1w25ob5 227 3 2001 2001 CD cord-006856-b1w25ob5 227 4 analysiert analysiert NN cord-006856-b1w25ob5 227 5 . . . cord-006856-b1w25ob5 228 1 Entsprechend Entsprechend NNP cord-006856-b1w25ob5 228 2 der der NNP cord-006856-b1w25ob5 228 3 Spender Spender NNP cord-006856-b1w25ob5 228 4 - - HYPH cord-006856-b1w25ob5 228 5 Natrium Natrium NNP cord-006856-b1w25ob5 228 6 - - HYPH cord-006856-b1w25ob5 228 7 Spiegel Spiegel NNP cord-006856-b1w25ob5 228 8 ( ( -LRB- cord-006856-b1w25ob5 228 9 SNS SNS NNP cord-006856-b1w25ob5 228 10 ) ) -RRB- cord-006856-b1w25ob5 228 11 wurde wurde NNP cord-006856-b1w25ob5 228 12 das das NNP cord-006856-b1w25ob5 228 13 Kollektiv Kollektiv NNP cord-006856-b1w25ob5 228 14 in in IN cord-006856-b1w25ob5 228 15 drei drei NNP cord-006856-b1w25ob5 228 16 Gruppen Gruppen NNP cord-006856-b1w25ob5 228 17 unterteilt unterteilt NN cord-006856-b1w25ob5 228 18 : : : cord-006856-b1w25ob5 229 1 Gruppe Gruppe NNP cord-006856-b1w25ob5 229 2 A A NNP cord-006856-b1w25ob5 229 3 , , , cord-006856-b1w25ob5 229 4 < < NNP cord-006856-b1w25ob5 229 5 160 160 CD cord-006856-b1w25ob5 229 6 mmol mmol XX cord-006856-b1w25ob5 230 1 Na Na NNP cord-006856-b1w25ob5 230 2 + + CC cord-006856-b1w25ob5 231 1 je je NNP cord-006856-b1w25ob5 231 2 Liter Liter NNP cord-006856-b1w25ob5 231 3 n n NN cord-006856-b1w25ob5 231 4 = = SYM cord-006856-b1w25ob5 231 5 2903 2903 CD cord-006856-b1w25ob5 231 6 ; ; : cord-006856-b1w25ob5 231 7 Gruppe Gruppe NNP cord-006856-b1w25ob5 231 8 B B NNP cord-006856-b1w25ob5 231 9 , , , cord-006856-b1w25ob5 232 1 160 160 CD cord-006856-b1w25ob5 232 2 - - SYM cord-006856-b1w25ob5 232 3 170 170 CD cord-006856-b1w25ob5 232 4 mmol mmol JJ cord-006856-b1w25ob5 232 5 Na Na NNP cord-006856-b1w25ob5 232 6 + + CC cord-006856-b1w25ob5 233 1 je je NNP cord-006856-b1w25ob5 233 2 Liter Liter NNP cord-006856-b1w25ob5 233 3 n n NN cord-006856-b1w25ob5 233 4 = = SYM cord-006856-b1w25ob5 233 5 218 218 CD cord-006856-b1w25ob5 233 6 ; ; : cord-006856-b1w25ob5 233 7 Gruppe Gruppe NNP cord-006856-b1w25ob5 233 8 C C NNP cord-006856-b1w25ob5 233 9 , , , cord-006856-b1w25ob5 233 10 ≥170 ≥170 CD cord-006856-b1w25ob5 233 11 mmol mmol JJ cord-006856-b1w25ob5 233 12 Na Na NNP cord-006856-b1w25ob5 233 13 + + CC cord-006856-b1w25ob5 234 1 je je NNP cord-006856-b1w25ob5 234 2 Liter Liter NNP cord-006856-b1w25ob5 234 3 n n NN cord-006856-b1w25ob5 234 4 = = SYM cord-006856-b1w25ob5 234 5 54 54 CD cord-006856-b1w25ob5 234 6 . . . cord-006856-b1w25ob5 235 1 Eine Eine NNP cord-006856-b1w25ob5 235 2 Kaplan Kaplan NNP cord-006856-b1w25ob5 235 3 - - HYPH cord-006856-b1w25ob5 235 4 Meier Meier NNP cord-006856-b1w25ob5 235 5 - - HYPH cord-006856-b1w25ob5 235 6 Überlebensanalyse Überlebensanalyse NNP cord-006856-b1w25ob5 235 7 und und NNP cord-006856-b1w25ob5 235 8 eine eine NNP cord-006856-b1w25ob5 236 1 multivariate multivariate NNP cord-006856-b1w25ob5 236 2 Analyse Analyse NNP cord-006856-b1w25ob5 236 3 bezüglich bezüglich FW cord-006856-b1w25ob5 236 4 des des FW cord-006856-b1w25ob5 236 5 Einflusses Einflusses NNP cord-006856-b1w25ob5 236 6 des des FW cord-006856-b1w25ob5 236 7 SNS SNS NNP cord-006856-b1w25ob5 236 8 wurden wurden NNS cord-006856-b1w25ob5 236 9 durchgeführt durchgeführt NNP cord-006856-b1w25ob5 236 10 . . . cord-006856-b1w25ob5 237 1 Endpunkte Endpunkte NNP cord-006856-b1w25ob5 237 2 waren waren NNP cord-006856-b1w25ob5 237 3 die die VBP cord-006856-b1w25ob5 238 1 Mortalität Mortalität NNP cord-006856-b1w25ob5 238 2 ein ein VBP cord-006856-b1w25ob5 238 3 Monat Monat NNP cord-006856-b1w25ob5 238 4 und und NNP cord-006856-b1w25ob5 238 5 ein ein NNP cord-006856-b1w25ob5 238 6 Jahr Jahr NNP cord-006856-b1w25ob5 238 7 nach nach NN cord-006856-b1w25ob5 238 8 HTX HTX NNP cord-006856-b1w25ob5 238 9 . . . cord-006856-b1w25ob5 239 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 239 2 . . . cord-006856-b1w25ob5 240 1 Der Der NNP cord-006856-b1w25ob5 240 2 SNS SNS NNP cord-006856-b1w25ob5 240 3 hatte hatte NNP cord-006856-b1w25ob5 240 4 in in IN cord-006856-b1w25ob5 240 5 der der NN cord-006856-b1w25ob5 240 6 univariaten univariaten NNP cord-006856-b1w25ob5 240 7 Analyse Analyse NNP cord-006856-b1w25ob5 240 8 keinen keinen NN cord-006856-b1w25ob5 240 9 Einfluss Einfluss NNP cord-006856-b1w25ob5 240 10 auf auf NNP cord-006856-b1w25ob5 241 1 die die VB cord-006856-b1w25ob5 241 2 Frühmortalität Frühmortalität NNP cord-006856-b1w25ob5 241 3 und und NNP cord-006856-b1w25ob5 241 4 einen einen NNP cord-006856-b1w25ob5 241 5 grenzwertig grenzwertig NNP cord-006856-b1w25ob5 241 6 signifikanten signifikanten NNP cord-006856-b1w25ob5 242 1 Einfluss Einfluss NNP cord-006856-b1w25ob5 242 2 auf auf NNS cord-006856-b1w25ob5 242 3 die die VBP cord-006856-b1w25ob5 242 4 1-Jahres 1-Jahres NNP cord-006856-b1w25ob5 242 5 - - HYPH cord-006856-b1w25ob5 242 6 Mortalität Mortalität NNP cord-006856-b1w25ob5 242 7 ( ( -LRB- cord-006856-b1w25ob5 242 8 P p NN cord-006856-b1w25ob5 242 9 = = SYM cord-006856-b1w25ob5 242 10 0,06 0,06 CD cord-006856-b1w25ob5 242 11 ) ) -RRB- cord-006856-b1w25ob5 242 12 . . . cord-006856-b1w25ob5 243 1 In in IN cord-006856-b1w25ob5 243 2 der der NNP cord-006856-b1w25ob5 243 3 multivariaten multivariaten NNP cord-006856-b1w25ob5 243 4 Analyse Analyse NNP cord-006856-b1w25ob5 243 5 war war NN cord-006856-b1w25ob5 243 6 dieser dieser NNP cord-006856-b1w25ob5 243 7 Effekt Effekt NNP cord-006856-b1w25ob5 243 8 nicht nicht NNP cord-006856-b1w25ob5 243 9 signifikant signifikant NNP cord-006856-b1w25ob5 243 10 ( ( -LRB- cord-006856-b1w25ob5 243 11 P p NN cord-006856-b1w25ob5 243 12 = = SYM cord-006856-b1w25ob5 243 13 0,2 0,2 CD cord-006856-b1w25ob5 243 14 ) ) -RRB- cord-006856-b1w25ob5 243 15 . . . cord-006856-b1w25ob5 244 1 Die die VB cord-006856-b1w25ob5 244 2 Kombination Kombination NNP cord-006856-b1w25ob5 244 3 aus aus NNP cord-006856-b1w25ob5 244 4 hohem hohem NNP cord-006856-b1w25ob5 244 5 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 244 6 mit mit NNP cord-006856-b1w25ob5 244 7 hohem hohem NNP cord-006856-b1w25ob5 244 8 SNS SNS NNP cord-006856-b1w25ob5 244 9 hatte hatte NNP cord-006856-b1w25ob5 244 10 jedoch jedoch NNP cord-006856-b1w25ob5 244 11 in in IN cord-006856-b1w25ob5 244 12 der der NNP cord-006856-b1w25ob5 244 13 multivariaten multivariaten NNP cord-006856-b1w25ob5 244 14 Analyse Analyse NNP cord-006856-b1w25ob5 244 15 einen einen NNP cord-006856-b1w25ob5 244 16 hochsignifikanten hochsignifikanten NNP cord-006856-b1w25ob5 245 1 Einfluss Einfluss NNP cord-006856-b1w25ob5 245 2 auf auf NNS cord-006856-b1w25ob5 245 3 die die VBP cord-006856-b1w25ob5 246 1 Früh Früh NNP cord-006856-b1w25ob5 246 2 - - HYPH cord-006856-b1w25ob5 246 3 und und NNP cord-006856-b1w25ob5 246 4 1-Jahresmortalität 1-jahresmortalität CD cord-006856-b1w25ob5 246 5 ( ( -LRB- cord-006856-b1w25ob5 246 6 P p NN cord-006856-b1w25ob5 246 7 = = SYM cord-006856-b1w25ob5 246 8 0,004 0,004 CD cord-006856-b1w25ob5 246 9 ) ) -RRB- cord-006856-b1w25ob5 246 10 . . . cord-006856-b1w25ob5 247 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 247 2 . . . cord-006856-b1w25ob5 248 1 Diese Diese NNP cord-006856-b1w25ob5 248 2 Daten Daten NNP cord-006856-b1w25ob5 248 3 zeigen zeigen NNP cord-006856-b1w25ob5 248 4 , , , cord-006856-b1w25ob5 249 1 dass dass NNP cord-006856-b1w25ob5 249 2 hohe hohe NNP cord-006856-b1w25ob5 249 3 SNS SNS NNP cord-006856-b1w25ob5 249 4 mit mit NNP cord-006856-b1w25ob5 249 5 einer einer NNP cord-006856-b1w25ob5 250 1 erhöhten erhöhten NNP cord-006856-b1w25ob5 251 1 Früh Früh NNP cord-006856-b1w25ob5 251 2 - - HYPH cord-006856-b1w25ob5 251 3 und und NNP cord-006856-b1w25ob5 251 4 1-Jahresmortalität 1-jahresmortalität CD cord-006856-b1w25ob5 251 5 nach nach NNP cord-006856-b1w25ob5 251 6 HTX HTX NNP cord-006856-b1w25ob5 251 7 einhergehen einhergehen NNP cord-006856-b1w25ob5 251 8 . . . cord-006856-b1w25ob5 252 1 Diese Diese NNP cord-006856-b1w25ob5 252 2 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 252 3 stehen stehen NNP cord-006856-b1w25ob5 252 4 i -PRON- PRP cord-006856-b1w25ob5 252 5 m be VBP cord-006856-b1w25ob5 253 1 Gegensatz Gegensatz NNP cord-006856-b1w25ob5 253 2 zu zu IN cord-006856-b1w25ob5 253 3 früheren früheren NNP cord-006856-b1w25ob5 253 4 Arbeiten Arbeiten NNP cord-006856-b1w25ob5 253 5 mit mit NNP cord-006856-b1w25ob5 253 6 geringeren geringeren NNP cord-006856-b1w25ob5 253 7 Patientenzahlen Patientenzahlen NNP cord-006856-b1w25ob5 253 8 . . . cord-006856-b1w25ob5 254 1 Vor Vor NNP cord-006856-b1w25ob5 254 2 allem allem NNP cord-006856-b1w25ob5 254 3 die die VB cord-006856-b1w25ob5 255 1 Kombination Kombination NNP cord-006856-b1w25ob5 255 2 aus aus NNP cord-006856-b1w25ob5 255 3 höherem höherem NNP cord-006856-b1w25ob5 255 4 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 255 5 und und XX cord-006856-b1w25ob5 256 1 hohem hohem NNP cord-006856-b1w25ob5 256 2 SNS SNS NNP cord-006856-b1w25ob5 256 3 zeigt zeigt NNP cord-006856-b1w25ob5 256 4 einen einen NNP cord-006856-b1w25ob5 256 5 deutlichen deutlichen NNP cord-006856-b1w25ob5 256 6 Risikoanstieg Risikoanstieg NNP cord-006856-b1w25ob5 256 7 . . . cord-006856-b1w25ob5 257 1 Herzen Herzen NNP cord-006856-b1w25ob5 257 2 von von NNP cord-006856-b1w25ob5 257 3 Spendern Spendern NNP cord-006856-b1w25ob5 258 1 mit mit NNP cord-006856-b1w25ob5 258 2 einem einem NNP cord-006856-b1w25ob5 258 3 Natriumspiegel Natriumspiegel NNP cord-006856-b1w25ob5 258 4 von von NNP cord-006856-b1w25ob5 259 1 > > XX cord-006856-b1w25ob5 259 2 170 170 CD cord-006856-b1w25ob5 259 3 mmol mmol JJ cord-006856-b1w25ob5 259 4 / / SYM cord-006856-b1w25ob5 259 5 l l NNP cord-006856-b1w25ob5 259 6 sollten sollten NNP cord-006856-b1w25ob5 259 7 nicht nicht NNP cord-006856-b1w25ob5 260 1 elektiv elektiv NNP cord-006856-b1w25ob5 260 2 transplantiert transplantiert NNP cord-006856-b1w25ob5 260 3 werden werden NNP cord-006856-b1w25ob5 260 4 , , , cord-006856-b1w25ob5 260 5 bei bei NNP cord-006856-b1w25ob5 260 6 gleichzeitig gleichzeitig NNP cord-006856-b1w25ob5 260 7 hohem hohem NNP cord-006856-b1w25ob5 261 1 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 261 2 sollte sollte NNP cord-006856-b1w25ob5 261 3 das das NNP cord-006856-b1w25ob5 261 4 Herz Herz NNP cord-006856-b1w25ob5 261 5 nicht nicht NNP cord-006856-b1w25ob5 261 6 verwendet verwendet NNP cord-006856-b1w25ob5 261 7 werden werden NNP cord-006856-b1w25ob5 261 8 . . . cord-006856-b1w25ob5 262 1 Die die VB cord-006856-b1w25ob5 262 2 Organempfänger Organempfänger NNP cord-006856-b1w25ob5 262 3 wurden wurden VBD cord-006856-b1w25ob5 262 4 entsprechend entsprechend VBG cord-006856-b1w25ob5 262 5 dem dem NNP cord-006856-b1w25ob5 262 6 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 262 7 in in IN cord-006856-b1w25ob5 262 8 2 2 CD cord-006856-b1w25ob5 262 9 Gruppen Gruppen NNP cord-006856-b1w25ob5 262 10 geteilt geteilt NN cord-006856-b1w25ob5 262 11 : : : cord-006856-b1w25ob5 262 12 Gruppe Gruppe NNP cord-006856-b1w25ob5 262 13 1 1 CD cord-006856-b1w25ob5 262 14 , , , cord-006856-b1w25ob5 262 15 < < XX cord-006856-b1w25ob5 262 16 35 35 CD cord-006856-b1w25ob5 262 17 a a DT cord-006856-b1w25ob5 262 18 , , , cord-006856-b1w25ob5 262 19 n n NN cord-006856-b1w25ob5 262 20 = = SYM cord-006856-b1w25ob5 262 21 12 12 CD cord-006856-b1w25ob5 262 22 ; ; : cord-006856-b1w25ob5 262 23 Gruppe Gruppe NNP cord-006856-b1w25ob5 262 24 2 2 CD cord-006856-b1w25ob5 262 25 , , , cord-006856-b1w25ob5 262 26 > > XX cord-006856-b1w25ob5 262 27 35a 35a NNS cord-006856-b1w25ob5 262 28 , , , cord-006856-b1w25ob5 262 29 n n NN cord-006856-b1w25ob5 262 30 = = SYM cord-006856-b1w25ob5 262 31 10 10 CD cord-006856-b1w25ob5 262 32 . . . cord-006856-b1w25ob5 263 1 Die die VB cord-006856-b1w25ob5 263 2 Gruppen Gruppen NNP cord-006856-b1w25ob5 263 3 waren waren NNP cord-006856-b1w25ob5 263 4 hinsichtlich hinsichtlich NNP cord-006856-b1w25ob5 263 5 Organischämiezeit Organischämiezeit NNP cord-006856-b1w25ob5 263 6 , , , cord-006856-b1w25ob5 263 7 Geschlechts Geschlechts NNP cord-006856-b1w25ob5 263 8 - - HYPH cord-006856-b1w25ob5 263 9 und und NNP cord-006856-b1w25ob5 264 1 CMV CMV NNP cord-006856-b1w25ob5 264 2 - - HYPH cord-006856-b1w25ob5 264 3 Mismatch Mismatch NNP cord-006856-b1w25ob5 264 4 sowie sowie NNP cord-006856-b1w25ob5 264 5 Lipidstatus Lipidstatus NNP cord-006856-b1w25ob5 264 6 , , , cord-006856-b1w25ob5 264 7 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 264 8 und und IN cord-006856-b1w25ob5 264 9 medikamentöse medikamentöse NNP cord-006856-b1w25ob5 264 10 Therapie Therapie NNP cord-006856-b1w25ob5 264 11 ( ( -LRB- cord-006856-b1w25ob5 264 12 Immunsuppresion Immunsuppresion NNP cord-006856-b1w25ob5 264 13 , , , cord-006856-b1w25ob5 264 14 ACE ACE NNP cord-006856-b1w25ob5 264 15 - - HYPH cord-006856-b1w25ob5 264 16 Hemmer Hemmer NNP cord-006856-b1w25ob5 264 17 , , , cord-006856-b1w25ob5 264 18 Statine Statine NNP cord-006856-b1w25ob5 264 19 , , , cord-006856-b1w25ob5 264 20 Ca Ca NNP cord-006856-b1w25ob5 264 21 - - HYPH cord-006856-b1w25ob5 264 22 Antagonisten Antagonisten NNP cord-006856-b1w25ob5 264 23 ) ) -RRB- cord-006856-b1w25ob5 265 1 1 1 LS cord-006856-b1w25ob5 266 1 Jahr Jahr NNP cord-006856-b1w25ob5 266 2 post post NN cord-006856-b1w25ob5 266 3 - - JJ cord-006856-b1w25ob5 266 4 HTx htx JJ cord-006856-b1w25ob5 266 5 vergleichbar vergleichbar NN cord-006856-b1w25ob5 266 6 . . . cord-006856-b1w25ob5 267 1 PV1 PV1 NNP cord-006856-b1w25ob5 267 2 war war NN cord-006856-b1w25ob5 267 3 in in IN cord-006856-b1w25ob5 267 4 Gruppe Gruppe NNP cord-006856-b1w25ob5 267 5 1 1 CD cord-006856-b1w25ob5 267 6 tendenziell tendenziell NNP cord-006856-b1w25ob5 267 7 niedriger niedriger NNP cord-006856-b1w25ob5 267 8 als als NNP cord-006856-b1w25ob5 267 9 in in IN cord-006856-b1w25ob5 267 10 Gruppe Gruppe NNP cord-006856-b1w25ob5 267 11 2 2 CD cord-006856-b1w25ob5 267 12 ( ( -LRB- cord-006856-b1w25ob5 267 13 25,2 25,2 CD cord-006856-b1w25ob5 267 14 ± ± NN cord-006856-b1w25ob5 267 15 17,3 17,3 CD cord-006856-b1w25ob5 267 16 mm mm CD cord-006856-b1w25ob5 267 17 3 3 CD cord-006856-b1w25ob5 268 1 vs. vs. FW cord-006856-b1w25ob5 268 2 34 34 CD cord-006856-b1w25ob5 268 3 ± ± CD cord-006856-b1w25ob5 268 4 22 22 CD cord-006856-b1w25ob5 268 5 mm mm CD cord-006856-b1w25ob5 268 6 3 3 CD cord-006856-b1w25ob5 268 7 ; ; : cord-006856-b1w25ob5 268 8 P p NN cord-006856-b1w25ob5 268 9 > > XX cord-006856-b1w25ob5 268 10 0,05 0,05 NN cord-006856-b1w25ob5 268 11 ) ) -RRB- cord-006856-b1w25ob5 268 12 . . . cord-006856-b1w25ob5 269 1 Umgekehrt Umgekehrt NNP cord-006856-b1w25ob5 269 2 wies wies NNP cord-006856-b1w25ob5 269 3 Gruppe Gruppe NNP cord-006856-b1w25ob5 269 4 1 1 CD cord-006856-b1w25ob5 270 1 i i PRP cord-006856-b1w25ob5 271 1 m m NNP cord-006856-b1w25ob5 271 2 Verlauf Verlauf NNP cord-006856-b1w25ob5 271 3 des des NNP cord-006856-b1w25ob5 271 4 1 1 CD cord-006856-b1w25ob5 271 5 . . . cord-006856-b1w25ob5 272 1 Jahres Jahres NNP cord-006856-b1w25ob5 272 2 nach nach VBP cord-006856-b1w25ob5 272 3 HTx HTx NNS cord-006856-b1w25ob5 272 4 einen einen VBP cord-006856-b1w25ob5 272 5 Zuwachs Zuwachs NNP cord-006856-b1w25ob5 272 6 an an DT cord-006856-b1w25ob5 272 7 Plaquevolumen Plaquevolumen NNP cord-006856-b1w25ob5 272 8 auf auf NNP cord-006856-b1w25ob5 272 9 , , , cord-006856-b1w25ob5 272 10 während während NNP cord-006856-b1w25ob5 272 11 in in IN cord-006856-b1w25ob5 272 12 Gruppe Gruppe NNP cord-006856-b1w25ob5 272 13 2 2 CD cord-006856-b1w25ob5 273 1 eine eine NNP cord-006856-b1w25ob5 273 2 Abnahme Abnahme NNP cord-006856-b1w25ob5 273 3 ( ( -LRB- cord-006856-b1w25ob5 273 4 ∆PV ∆PV NNP cord-006856-b1w25ob5 273 5 , , , cord-006856-b1w25ob5 273 6 2,6 2,6 CD cord-006856-b1w25ob5 273 7 ± ± NN cord-006856-b1w25ob5 274 1 17,6 17,6 CD cord-006856-b1w25ob5 274 2 mm mm NNP cord-006856-b1w25ob5 274 3 3 3 CD cord-006856-b1w25ob5 275 1 vs. vs. FW cord-006856-b1w25ob5 275 2 3,0 3,0 CD cord-006856-b1w25ob5 275 3 ± ± NNP cord-006856-b1w25ob5 276 1 10,2 10,2 CD cord-006856-b1w25ob5 276 2 mm mm NNP cord-006856-b1w25ob5 276 3 3 3 CD cord-006856-b1w25ob5 276 4 ; ; : cord-006856-b1w25ob5 276 5 P p NN cord-006856-b1w25ob5 276 6 > > XX cord-006856-b1w25ob5 276 7 0,05 0,05 NN cord-006856-b1w25ob5 276 8 ) ) -RRB- cord-006856-b1w25ob5 276 9 festgestellt festgestellt NNP cord-006856-b1w25ob5 276 10 wurde wurde NNP cord-006856-b1w25ob5 276 11 . . . cord-006856-b1w25ob5 277 1 Von Von NNP cord-006856-b1w25ob5 277 2 den den NNP cord-006856-b1w25ob5 277 3 oben oben NNP cord-006856-b1w25ob5 277 4 angeführten angeführten NNP cord-006856-b1w25ob5 277 5 Risikoparametern Risikoparametern NNP cord-006856-b1w25ob5 277 6 zeigte zeigte NNP cord-006856-b1w25ob5 277 7 lediglich lediglich NNP cord-006856-b1w25ob5 278 1 der der NNP cord-006856-b1w25ob5 278 2 Triglyzeridspiegel Triglyzeridspiegel NNP cord-006856-b1w25ob5 278 3 1 1 CD cord-006856-b1w25ob5 278 4 Jahr Jahr NNP cord-006856-b1w25ob5 278 5 post post NN cord-006856-b1w25ob5 278 6 HTx HTx NNS cord-006856-b1w25ob5 278 7 eine eine NNP cord-006856-b1w25ob5 278 8 signifikante signifikante JJ cord-006856-b1w25ob5 278 9 Korrelation Korrelation NNP cord-006856-b1w25ob5 278 10 mit mit NNP cord-006856-b1w25ob5 278 11 ∆PV ∆PV NNP cord-006856-b1w25ob5 279 1 ( ( -LRB- cord-006856-b1w25ob5 279 2 r r NN cord-006856-b1w25ob5 279 3 = = SYM cord-006856-b1w25ob5 279 4 -0,613 -0,613 NN cord-006856-b1w25ob5 279 5 , , , cord-006856-b1w25ob5 279 6 P p NN cord-006856-b1w25ob5 279 7 = = SYM cord-006856-b1w25ob5 279 8 0,002 0,002 CD cord-006856-b1w25ob5 279 9 ) ) -RRB- cord-006856-b1w25ob5 279 10 . . . cord-006856-b1w25ob5 280 1 ∆PV ∆PV NNP cord-006856-b1w25ob5 280 2 und und XX cord-006856-b1w25ob5 281 1 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 281 2 waren waren NNP cord-006856-b1w25ob5 281 3 nicht nicht NNP cord-006856-b1w25ob5 281 4 miteinander miteinander NNP cord-006856-b1w25ob5 281 5 korreliert korreliert NNP cord-006856-b1w25ob5 281 6 . . . cord-006856-b1w25ob5 282 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 282 2 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 282 3 . . . cord-006856-b1w25ob5 283 1 Die die VB cord-006856-b1w25ob5 283 2 Mortalität Mortalität NNP cord-006856-b1w25ob5 283 3 beträgt beträgt VB cord-006856-b1w25ob5 283 4 0 0 CD cord-006856-b1w25ob5 283 5 % % NN cord-006856-b1w25ob5 283 6 . . . cord-006856-b1w25ob5 284 1 Wegen Wegen NNP cord-006856-b1w25ob5 284 2 gastrointestinaler gastrointestinaler NN cord-006856-b1w25ob5 284 3 Beschwerden Beschwerden NNP cord-006856-b1w25ob5 285 1 ( ( -LRB- cord-006856-b1w25ob5 285 2 Übelkeit Übelkeit NNP cord-006856-b1w25ob5 285 3 , , , cord-006856-b1w25ob5 285 4 Erbrechen Erbrechen NNP cord-006856-b1w25ob5 285 5 ) ) -RRB- cord-006856-b1w25ob5 285 6 mussten mussten VBD cord-006856-b1w25ob5 285 7 3 3 CD cord-006856-b1w25ob5 286 1 Patienten Patienten NNP cord-006856-b1w25ob5 286 2 ( ( -LRB- cord-006856-b1w25ob5 286 3 12 12 CD cord-006856-b1w25ob5 286 4 % % NN cord-006856-b1w25ob5 286 5 ) ) -RRB- cord-006856-b1w25ob5 287 1 auf auf NNP cord-006856-b1w25ob5 287 2 ein ein NNP cord-006856-b1w25ob5 287 3 anderes anderes FW cord-006856-b1w25ob5 287 4 immunsuppressives immunsuppressives NNP cord-006856-b1w25ob5 287 5 Schema schema VB cord-006856-b1w25ob5 287 6 umgestellt umgestellt NNP cord-006856-b1w25ob5 287 7 werden werden NNP cord-006856-b1w25ob5 287 8 . . . cord-006856-b1w25ob5 288 1 Bei Bei NNP cord-006856-b1w25ob5 288 2 2 2 CD cord-006856-b1w25ob5 289 1 Patienten Patienten NNP cord-006856-b1w25ob5 290 1 ( ( -LRB- cord-006856-b1w25ob5 290 2 Everolimus Everolimus NNP cord-006856-b1w25ob5 290 3 - - HYPH cord-006856-b1w25ob5 290 4 Talspiegel Talspiegel NNP cord-006856-b1w25ob5 290 5 , , , cord-006856-b1w25ob5 290 6 > > XX cord-006856-b1w25ob5 291 1 8 8 CD cord-006856-b1w25ob5 291 2 ng ng NN cord-006856-b1w25ob5 291 3 / / SYM cord-006856-b1w25ob5 291 4 ml ml NN cord-006856-b1w25ob5 291 5 ) ) -RRB- cord-006856-b1w25ob5 291 6 zeigte zeigte NNP cord-006856-b1w25ob5 291 7 sich sich NNP cord-006856-b1w25ob5 291 8 eine eine NNP cord-006856-b1w25ob5 291 9 schwere schwere JJ cord-006856-b1w25ob5 291 10 Pneumonie Pneumonie NNP cord-006856-b1w25ob5 291 11 ( ( -LRB- cord-006856-b1w25ob5 291 12 Pseudomonas Pseudomonas NNP cord-006856-b1w25ob5 291 13 ) ) -RRB- cord-006856-b1w25ob5 291 14 , , , cord-006856-b1w25ob5 291 15 welche welche NNP cord-006856-b1w25ob5 291 16 stationär stationär NNP cord-006856-b1w25ob5 291 17 behandelt behandelt NNP cord-006856-b1w25ob5 291 18 wurde wurde NNP cord-006856-b1w25ob5 291 19 . . . cord-006856-b1w25ob5 292 1 Es Es NNP cord-006856-b1w25ob5 292 2 gab gab NN cord-006856-b1w25ob5 293 1 keine keine NNP cord-006856-b1w25ob5 293 2 stationäre stationäre NNP cord-006856-b1w25ob5 293 3 Behandlung Behandlung NNP cord-006856-b1w25ob5 293 4 wegen wegen NNP cord-006856-b1w25ob5 293 5 CMV CMV NNP cord-006856-b1w25ob5 293 6 - - HYPH cord-006856-b1w25ob5 293 7 Infekten Infekten NNP cord-006856-b1w25ob5 293 8 . . . cord-006856-b1w25ob5 294 1 Die die VB cord-006856-b1w25ob5 294 2 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 294 3 war war NN cord-006856-b1w25ob5 294 4 in in IN cord-006856-b1w25ob5 294 5 allen allen NNP cord-006856-b1w25ob5 294 6 Patienten Patienten NNP cord-006856-b1w25ob5 294 7 stabil stabil NNP cord-006856-b1w25ob5 294 8 ( ( -LRB- cord-006856-b1w25ob5 294 9 mittleres mittleres NNP cord-006856-b1w25ob5 294 10 Crea Crea NNP cord-006856-b1w25ob5 294 11 , , , cord-006856-b1w25ob5 294 12 1,84 1,84 CD cord-006856-b1w25ob5 294 13 ± ± CD cord-006856-b1w25ob5 294 14 0,85 0,85 CD cord-006856-b1w25ob5 294 15 ) ) -RRB- cord-006856-b1w25ob5 294 16 , , , cord-006856-b1w25ob5 294 17 außer außer NNP cord-006856-b1w25ob5 294 18 in in IN cord-006856-b1w25ob5 294 19 2 2 CD cord-006856-b1w25ob5 294 20 Patienten Patienten NNP cord-006856-b1w25ob5 294 21 , , , cord-006856-b1w25ob5 294 22 welche welche NNP cord-006856-b1w25ob5 294 23 bereits bereits NNP cord-006856-b1w25ob5 294 24 vor vor NNP cord-006856-b1w25ob5 294 25 der der NNP cord-006856-b1w25ob5 294 26 Umstellung Umstellung NNP cord-006856-b1w25ob5 294 27 erhöhte erhöhte NNP cord-006856-b1w25ob5 294 28 Kreatininwerte Kreatininwerte NNP cord-006856-b1w25ob5 294 29 zeigten zeigten NNP cord-006856-b1w25ob5 294 30 und und NNP cord-006856-b1w25ob5 294 31 in in IN cord-006856-b1w25ob5 294 32 denen denen NNP cord-006856-b1w25ob5 294 33 sich sich NNP cord-006856-b1w25ob5 294 34 eine eine NNP cord-006856-b1w25ob5 294 35 weitere weitere NNP cord-006856-b1w25ob5 294 36 Erhöhung Erhöhung NNP cord-006856-b1w25ob5 294 37 der der NNP cord-006856-b1w25ob5 294 38 Kreatininwerte Kreatininwerte NNP cord-006856-b1w25ob5 294 39 ( ( -LRB- cord-006856-b1w25ob5 294 40 +20,25 +20,25 NNP cord-006856-b1w25ob5 294 41 % % NN cord-006856-b1w25ob5 294 42 ) ) -RRB- cord-006856-b1w25ob5 294 43 feststellen feststellen NNP cord-006856-b1w25ob5 294 44 ließ ließ NNP cord-006856-b1w25ob5 294 45 . . . cord-006856-b1w25ob5 295 1 Eine Eine NNP cord-006856-b1w25ob5 295 2 bei bei NNP cord-006856-b1w25ob5 295 3 den den NNP cord-006856-b1w25ob5 296 1 meisten meisten NNP cord-006856-b1w25ob5 296 2 Patienten Patienten NNP cord-006856-b1w25ob5 296 3 auftretende auftretende NNP cord-006856-b1w25ob5 296 4 Hyperlipidämie Hyperlipidämie NNP cord-006856-b1w25ob5 296 5 konnte konnte NNP cord-006856-b1w25ob5 296 6 unter unter NNP cord-006856-b1w25ob5 297 1 Erhöhung Erhöhung NNP cord-006856-b1w25ob5 297 2 der der NNP cord-006856-b1w25ob5 297 3 Statintherapie Statintherapie NNP cord-006856-b1w25ob5 297 4 eingestellt eingestellt NNP cord-006856-b1w25ob5 297 5 werden werden NNP cord-006856-b1w25ob5 297 6 . . . cord-006856-b1w25ob5 298 1 In in IN cord-006856-b1w25ob5 298 2 den den NNP cord-006856-b1w25ob5 298 3 routinemäßig routinemäßig NNP cord-006856-b1w25ob5 298 4 durchgeführten durchgeführten NNP cord-006856-b1w25ob5 299 1 Endomyocard Endomyocard NNP cord-006856-b1w25ob5 299 2 - - HYPH cord-006856-b1w25ob5 299 3 Biopsien Biopsien NNP cord-006856-b1w25ob5 299 4 fanden fanden NNP cord-006856-b1w25ob5 299 5 sich sich NNP cord-006856-b1w25ob5 299 6 einen einen NNP cord-006856-b1w25ob5 299 7 Monat Monat NNP cord-006856-b1w25ob5 299 8 nach nach NNP cord-006856-b1w25ob5 299 9 Umstellung Umstellung NNP cord-006856-b1w25ob5 299 10 und und IN cord-006856-b1w25ob5 299 11 danach danach NNP cord-006856-b1w25ob5 299 12 keine keine NNP cord-006856-b1w25ob5 299 13 akuten akuten NNP cord-006856-b1w25ob5 299 14 zellulären zellulären NNP cord-006856-b1w25ob5 299 15 Abstoßungen Abstoßungen NNP cord-006856-b1w25ob5 299 16 mit mit NNP cord-006856-b1w25ob5 299 17 Grad Grad NNP cord-006856-b1w25ob5 299 18 von von NNP cord-006856-b1w25ob5 300 1 > > XX cord-006856-b1w25ob5 301 1 1b 1b NNP cord-006856-b1w25ob5 301 2 nach nach NNP cord-006856-b1w25ob5 301 3 dem dem NNP cord-006856-b1w25ob5 301 4 ISHLT ISHLT NNP cord-006856-b1w25ob5 301 5 - - HYPH cord-006856-b1w25ob5 301 6 Grading Grading NNP cord-006856-b1w25ob5 301 7 . . . cord-006856-b1w25ob5 302 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 302 2 . . . cord-006856-b1w25ob5 303 1 Certican Certican NNP cord-006856-b1w25ob5 303 2 erwies erwie VBZ cord-006856-b1w25ob5 303 3 sich sich NNP cord-006856-b1w25ob5 303 4 als als NNP cord-006856-b1w25ob5 303 5 sicher sicher NNP cord-006856-b1w25ob5 303 6 und und NNP cord-006856-b1w25ob5 303 7 verträglich verträglich NNP cord-006856-b1w25ob5 303 8 , , , cord-006856-b1w25ob5 303 9 die die VB cord-006856-b1w25ob5 303 10 Umstellung Umstellung NNP cord-006856-b1w25ob5 303 11 auf auf NNP cord-006856-b1w25ob5 303 12 das das NNP cord-006856-b1w25ob5 303 13 neue neue NNP cord-006856-b1w25ob5 303 14 Immunsuppressivum Immunsuppressivum NNP cord-006856-b1w25ob5 303 15 war war NN cord-006856-b1w25ob5 303 16 in in IN cord-006856-b1w25ob5 303 17 allen allen NNP cord-006856-b1w25ob5 303 18 Patienten Patienten NNP cord-006856-b1w25ob5 303 19 komplikationslos komplikationslos NNP cord-006856-b1w25ob5 303 20 . . . cord-006856-b1w25ob5 304 1 Everolimus Everolimus NNP cord-006856-b1w25ob5 304 2 - - HYPH cord-006856-b1w25ob5 304 3 Talspiegel Talspiegel NNP cord-006856-b1w25ob5 304 4 von von NNP cord-006856-b1w25ob5 304 5 8 8 CD cord-006856-b1w25ob5 304 6 ng ng NNP cord-006856-b1w25ob5 304 7 / / SYM cord-006856-b1w25ob5 304 8 ml ml NNP cord-006856-b1w25ob5 304 9 scheinen scheinen NNP cord-006856-b1w25ob5 304 10 ausreichend ausreichend NNP cord-006856-b1w25ob5 304 11 , , , cord-006856-b1w25ob5 304 12 höhere höhere NNP cord-006856-b1w25ob5 304 13 Spiegel Spiegel NNP cord-006856-b1w25ob5 304 14 könnten könnten VBD cord-006856-b1w25ob5 304 15 das das NNP cord-006856-b1w25ob5 304 16 Infektionsrisiko Infektionsrisiko NNP cord-006856-b1w25ob5 304 17 erhöhen erhöhen NNP cord-006856-b1w25ob5 304 18 . . . cord-006856-b1w25ob5 305 1 Bezüglich Bezüglich NNP cord-006856-b1w25ob5 305 2 der der NNP cord-006856-b1w25ob5 305 3 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 305 4 bleibt bleibt NNP cord-006856-b1w25ob5 305 5 abzuwarten abzuwarten NNP cord-006856-b1w25ob5 305 6 , , , cord-006856-b1w25ob5 305 7 wie wie NNP cord-006856-b1w25ob5 305 8 sich sich NNP cord-006856-b1w25ob5 305 9 ein ein NNP cord-006856-b1w25ob5 305 10 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 305 11 - - HYPH cord-006856-b1w25ob5 305 12 A A NNP cord-006856-b1w25ob5 305 13 - - HYPH cord-006856-b1w25ob5 305 14 Talspiegel Talspiegel NNP cord-006856-b1w25ob5 305 15 von von NNP cord-006856-b1w25ob5 305 16 60 60 CD cord-006856-b1w25ob5 305 17 - - SYM cord-006856-b1w25ob5 305 18 80 80 CD cord-006856-b1w25ob5 305 19 ng ng NN cord-006856-b1w25ob5 305 20 / / SYM cord-006856-b1w25ob5 305 21 ml ml NN cord-006856-b1w25ob5 305 22 auswirkt auswirkt NNP cord-006856-b1w25ob5 305 23 . . . cord-006856-b1w25ob5 306 1 Eine Eine NNP cord-006856-b1w25ob5 306 2 Aussage Aussage NNP cord-006856-b1w25ob5 306 3 bezüglich bezüglich NNP cord-006856-b1w25ob5 306 4 der der NNP cord-006856-b1w25ob5 306 5 CAV CAV NNP cord-006856-b1w25ob5 306 6 steht steht NNP cord-006856-b1w25ob5 306 7 zu zu NNP cord-006856-b1w25ob5 306 8 diesem diesem NNP cord-006856-b1w25ob5 306 9 Zeitpunkt Zeitpunkt NNP cord-006856-b1w25ob5 306 10 noch noch NNP cord-006856-b1w25ob5 306 11 aus aus NNP cord-006856-b1w25ob5 306 12 . . . cord-006856-b1w25ob5 307 1 V17 V17 NNP cord-006856-b1w25ob5 308 1 20 20 CD cord-006856-b1w25ob5 308 2 Jahre Jahre NNP cord-006856-b1w25ob5 308 3 Herztransplantation Herztransplantation NNP cord-006856-b1w25ob5 308 4 in in IN cord-006856-b1w25ob5 308 5 Wien Wien NNP cord-006856-b1w25ob5 308 6 _SP cord-006856-b1w25ob5 308 7 ( ( -LRB- cord-006856-b1w25ob5 308 8 eine eine NNP cord-006856-b1w25ob5 308 9 Retrospektive Retrospektive NNP cord-006856-b1w25ob5 308 10 über über NNP cord-006856-b1w25ob5 308 11 1000 1000 CD cord-006856-b1w25ob5 309 1 Transplantationen Transplantationen NNP cord-006856-b1w25ob5 309 2 ) ) -RRB- cord-006856-b1w25ob5 309 3 A. a. NN cord-006856-b1w25ob5 309 4 Zuckermann Zuckermann NNP cord-006856-b1w25ob5 309 5 Empfänger Empfänger NNP cord-006856-b1w25ob5 309 6 - - HYPH cord-006856-b1w25ob5 309 7 und und NNP cord-006856-b1w25ob5 310 1 Spenderalter Spenderalter NNP cord-006856-b1w25ob5 310 2 sind sind NNP cord-006856-b1w25ob5 311 1 i -PRON- PRP cord-006856-b1w25ob5 311 2 m be VBP cord-006856-b1w25ob5 311 3 Laufe Laufe NNP cord-006856-b1w25ob5 311 4 der der NNP cord-006856-b1w25ob5 311 5 Jahre Jahre NNP cord-006856-b1w25ob5 311 6 signifikant signifikant NN cord-006856-b1w25ob5 311 7 gestiegen gestiegen NN cord-006856-b1w25ob5 311 8 ( ( -LRB- cord-006856-b1w25ob5 311 9 recipient recipient NN cord-006856-b1w25ob5 311 10 age age NN cord-006856-b1w25ob5 311 11 : : : cord-006856-b1w25ob5 312 1 42,5 42,5 LS cord-006856-b1w25ob5 312 2 ± ± CD cord-006856-b1w25ob5 312 3 11,8 11,8 CD cord-006856-b1w25ob5 312 4 vs. vs. CC cord-006856-b1w25ob5 312 5 52,0 52,0 CD cord-006856-b1w25ob5 312 6 ± ± NNP cord-006856-b1w25ob5 312 7 13,8 13,8 CD cord-006856-b1w25ob5 312 8 , , , cord-006856-b1w25ob5 312 9 P p NN cord-006856-b1w25ob5 312 10 < < XX cord-006856-b1w25ob5 312 11 0,05 0,05 XX cord-006856-b1w25ob5 312 12 ; ; : cord-006856-b1w25ob5 312 13 donor donor NN cord-006856-b1w25ob5 312 14 age age NN cord-006856-b1w25ob5 312 15 , , , cord-006856-b1w25ob5 312 16 28,8 28,8 CD cord-006856-b1w25ob5 312 17 ± ± NN cord-006856-b1w25ob5 312 18 10,3 10,3 CD cord-006856-b1w25ob5 312 19 vs. vs. CC cord-006856-b1w25ob5 312 20 35,2 35,2 CD cord-006856-b1w25ob5 312 21 ± ± CD cord-006856-b1w25ob5 312 22 12,9 12,9 CD cord-006856-b1w25ob5 312 23 , , , cord-006856-b1w25ob5 312 24 P p NN cord-006856-b1w25ob5 312 25 < < XX cord-006856-b1w25ob5 312 26 0,01 0,01 NN cord-006856-b1w25ob5 312 27 ) ) -RRB- cord-006856-b1w25ob5 312 28 . . . cord-006856-b1w25ob5 313 1 Mehr Mehr NNP cord-006856-b1w25ob5 313 2 Patienten Patienten NNP cord-006856-b1w25ob5 313 3 wurden wurden VBD cord-006856-b1w25ob5 313 4 präoperativ präoperativ NNP cord-006856-b1w25ob5 313 5 stationär stationär NNP cord-006856-b1w25ob5 313 6 aufgenommen aufgenommen NNP cord-006856-b1w25ob5 313 7 ( ( -LRB- cord-006856-b1w25ob5 313 8 28 28 CD cord-006856-b1w25ob5 313 9 % % NN cord-006856-b1w25ob5 313 10 vs. vs. IN cord-006856-b1w25ob5 313 11 44 44 CD cord-006856-b1w25ob5 313 12 % % NN cord-006856-b1w25ob5 313 13 ) ) -RRB- cord-006856-b1w25ob5 314 1 , , , cord-006856-b1w25ob5 314 2 jedoch jedoch NNP cord-006856-b1w25ob5 314 3 hat hat NN cord-006856-b1w25ob5 314 4 sich sich NNP cord-006856-b1w25ob5 314 5 die die VBP cord-006856-b1w25ob5 315 1 Zahl Zahl NNP cord-006856-b1w25ob5 315 2 der der NNP cord-006856-b1w25ob5 315 3 intensivpflichtigen intensivpflichtigen NNP cord-006856-b1w25ob5 316 1 Patienten Patienten NNP cord-006856-b1w25ob5 316 2 signifikant signifikant NN cord-006856-b1w25ob5 316 3 reduziert reduziert NNP cord-006856-b1w25ob5 316 4 ( ( -LRB- cord-006856-b1w25ob5 316 5 21 21 CD cord-006856-b1w25ob5 316 6 % % NN cord-006856-b1w25ob5 316 7 vs. vs. CC cord-006856-b1w25ob5 316 8 7 7 CD cord-006856-b1w25ob5 316 9 % % NN cord-006856-b1w25ob5 316 10 ) ) -RRB- cord-006856-b1w25ob5 316 11 . . . cord-006856-b1w25ob5 317 1 Die die VB cord-006856-b1w25ob5 317 2 Zahl Zahl NNP cord-006856-b1w25ob5 317 3 der der NNP cord-006856-b1w25ob5 317 4 Patienten Patienten NNP cord-006856-b1w25ob5 317 5 , , , cord-006856-b1w25ob5 317 6 die die VB cord-006856-b1w25ob5 317 7 zur zur NNP cord-006856-b1w25ob5 317 8 Transplantation transplantation NN cord-006856-b1w25ob5 318 1 " " `` cord-006856-b1w25ob5 318 2 gebridged gebridged JJ cord-006856-b1w25ob5 318 3 " " '' cord-006856-b1w25ob5 318 4 werden werden NNP cord-006856-b1w25ob5 318 5 , , , cord-006856-b1w25ob5 318 6 ist ist NNP cord-006856-b1w25ob5 318 7 ebenfalls ebenfalls NNP cord-006856-b1w25ob5 318 8 massiv massiv NNP cord-006856-b1w25ob5 318 9 angestiegen angestiegen NNP cord-006856-b1w25ob5 318 10 ( ( -LRB- cord-006856-b1w25ob5 318 11 28 28 CD cord-006856-b1w25ob5 318 12 vs. vs. CC cord-006856-b1w25ob5 318 13 63 63 CD cord-006856-b1w25ob5 318 14 % % NN cord-006856-b1w25ob5 318 15 , , , cord-006856-b1w25ob5 318 16 P p NN cord-006856-b1w25ob5 318 17 < < XX cord-006856-b1w25ob5 318 18 0,01 0,01 NN cord-006856-b1w25ob5 318 19 ) ) -RRB- cord-006856-b1w25ob5 318 20 . . . cord-006856-b1w25ob5 319 1 Innerhalb Innerhalb NNP cord-006856-b1w25ob5 319 2 dieser dieser NNP cord-006856-b1w25ob5 319 3 Gruppe Gruppe NNP cord-006856-b1w25ob5 319 4 hat hat NN cord-006856-b1w25ob5 319 5 die die VBP cord-006856-b1w25ob5 319 6 Gruppe Gruppe NNP cord-006856-b1w25ob5 319 7 der der NNP cord-006856-b1w25ob5 319 8 Patienten Patienten NNP cord-006856-b1w25ob5 319 9 mit mit NNP cord-006856-b1w25ob5 319 10 mechanischer mechanischer JJ cord-006856-b1w25ob5 319 11 Herzunterstützung Herzunterstützung NNP cord-006856-b1w25ob5 319 12 am be VBP cord-006856-b1w25ob5 319 13 stärksten stärksten JJ cord-006856-b1w25ob5 319 14 zugenommen zugenommen NNP cord-006856-b1w25ob5 319 15 ( ( -LRB- cord-006856-b1w25ob5 319 16 7 7 CD cord-006856-b1w25ob5 319 17 % % NN cord-006856-b1w25ob5 319 18 vs. vs. CC cord-006856-b1w25ob5 319 19 19 19 CD cord-006856-b1w25ob5 319 20 % % NN cord-006856-b1w25ob5 319 21 , , , cord-006856-b1w25ob5 319 22 P p NN cord-006856-b1w25ob5 319 23 < < XX cord-006856-b1w25ob5 319 24 0,01 0,01 NN cord-006856-b1w25ob5 319 25 ) ) -RRB- cord-006856-b1w25ob5 319 26 . . . cord-006856-b1w25ob5 320 1 Pharmakologisches Pharmakologisches NNP cord-006856-b1w25ob5 320 2 Bridging Bridging NNP cord-006856-b1w25ob5 320 3 ( ( -LRB- cord-006856-b1w25ob5 320 4 55 55 CD cord-006856-b1w25ob5 320 5 % % NN cord-006856-b1w25ob5 320 6 vs. vs. IN cord-006856-b1w25ob5 320 7 42 42 CD cord-006856-b1w25ob5 320 8 % % NN cord-006856-b1w25ob5 320 9 ) ) -RRB- cord-006856-b1w25ob5 320 10 und und NNP cord-006856-b1w25ob5 320 11 AICD AICD NNP cord-006856-b1w25ob5 320 12 ( ( -LRB- cord-006856-b1w25ob5 320 13 38 38 CD cord-006856-b1w25ob5 320 14 % % NN cord-006856-b1w25ob5 320 15 vs.40 vs.40 NNP cord-006856-b1w25ob5 320 16 % % NN cord-006856-b1w25ob5 320 17 ) ) -RRB- cord-006856-b1w25ob5 321 1 blieben blieben NNP cord-006856-b1w25ob5 321 2 stabil stabil NNP cord-006856-b1w25ob5 321 3 . . . cord-006856-b1w25ob5 322 1 Pharmakologisches Pharmakologisches NNP cord-006856-b1w25ob5 323 1 Bridging bridge VBG cord-006856-b1w25ob5 323 2 wird wird JJ cord-006856-b1w25ob5 323 3 heutzutage heutzutage NNP cord-006856-b1w25ob5 324 1 vermehrt vermehrt NNP cord-006856-b1w25ob5 324 2 mit mit NNP cord-006856-b1w25ob5 324 3 Prostaglandinen Prostaglandinen NNP cord-006856-b1w25ob5 325 1 und und IN cord-006856-b1w25ob5 325 2 Levusimendan Levusimendan NNP cord-006856-b1w25ob5 325 3 als als NN cord-006856-b1w25ob5 325 4 mit mit NNP cord-006856-b1w25ob5 325 5 Dopamin Dopamin NNP cord-006856-b1w25ob5 325 6 oder oder NNP cord-006856-b1w25ob5 325 7 Dobutamin Dobutamin NNP cord-006856-b1w25ob5 325 8 durchgeführt durchgeführt NN cord-006856-b1w25ob5 325 9 . . . cord-006856-b1w25ob5 326 1 Mehr Mehr NNP cord-006856-b1w25ob5 326 2 Patienten Patienten NNP cord-006856-b1w25ob5 326 3 sind sind NNPS cord-006856-b1w25ob5 326 4 am be VBP cord-006856-b1w25ob5 326 5 Herzen Herzen NNP cord-006856-b1w25ob5 326 6 voroperiert voroperiert NN cord-006856-b1w25ob5 326 7 ( ( -LRB- cord-006856-b1w25ob5 326 8 28 28 CD cord-006856-b1w25ob5 326 9 % % NN cord-006856-b1w25ob5 326 10 vs. vs. CC cord-006856-b1w25ob5 326 11 52 52 CD cord-006856-b1w25ob5 326 12 % % NN cord-006856-b1w25ob5 326 13 , , , cord-006856-b1w25ob5 326 14 P p NN cord-006856-b1w25ob5 326 15 < < XX cord-006856-b1w25ob5 326 16 0,01 0,01 NN cord-006856-b1w25ob5 326 17 ) ) -RRB- cord-006856-b1w25ob5 326 18 , , . cord-006856-b1w25ob5 327 1 Patienten Patienten NNP cord-006856-b1w25ob5 327 2 warten warten NNP cord-006856-b1w25ob5 327 3 länger länger NNP cord-006856-b1w25ob5 327 4 auf auf NNP cord-006856-b1w25ob5 328 1 die die VB cord-006856-b1w25ob5 328 2 Transplantation transplantation NN cord-006856-b1w25ob5 329 1 ( ( -LRB- cord-006856-b1w25ob5 329 2 75,9 75,9 CD cord-006856-b1w25ob5 329 3 ± ± CD cord-006856-b1w25ob5 329 4 91,6 91,6 CD cord-006856-b1w25ob5 329 5 vs. vs. IN cord-006856-b1w25ob5 330 1 289,8 289,8 CD cord-006856-b1w25ob5 330 2 ± ± NNP cord-006856-b1w25ob5 330 3 368,8 368,8 NNP cord-006856-b1w25ob5 330 4 , , , cord-006856-b1w25ob5 330 5 P p NN cord-006856-b1w25ob5 330 6 < < XX cord-006856-b1w25ob5 330 7 0,01 0,01 NN cord-006856-b1w25ob5 330 8 ) ) -RRB- cord-006856-b1w25ob5 330 9 . . . cord-006856-b1w25ob5 331 1 Trotzdem Trotzdem NNP cord-006856-b1w25ob5 331 2 hat hat NN cord-006856-b1w25ob5 331 3 sich sich NN cord-006856-b1w25ob5 331 4 die die VB cord-006856-b1w25ob5 332 1 Mortalität Mortalität NNP cord-006856-b1w25ob5 332 2 auf auf NNP cord-006856-b1w25ob5 332 3 der der NNP cord-006856-b1w25ob5 332 4 Warteliste Warteliste NNP cord-006856-b1w25ob5 332 5 stark stark JJ cord-006856-b1w25ob5 332 6 verbessert verbessert NNP cord-006856-b1w25ob5 332 7 ( ( -LRB- cord-006856-b1w25ob5 332 8 27,6 27,6 CD cord-006856-b1w25ob5 332 9 % % NN cord-006856-b1w25ob5 332 10 vs. vs. IN cord-006856-b1w25ob5 332 11 12,0 12,0 CD cord-006856-b1w25ob5 332 12 % % NN cord-006856-b1w25ob5 332 13 , , , cord-006856-b1w25ob5 332 14 P p NN cord-006856-b1w25ob5 332 15 < < XX cord-006856-b1w25ob5 332 16 0,01 0,01 NN cord-006856-b1w25ob5 332 17 ) ) -RRB- cord-006856-b1w25ob5 332 18 , , , cord-006856-b1w25ob5 332 19 was be VBD cord-006856-b1w25ob5 332 20 ein ein FW cord-006856-b1w25ob5 332 21 klares klares NNP cord-006856-b1w25ob5 332 22 Zeichen Zeichen NNP cord-006856-b1w25ob5 332 23 der der NN cord-006856-b1w25ob5 332 24 verbesserten verbesserten NNP cord-006856-b1w25ob5 332 25 Überbrückungsmaßnahmen Überbrückungsmaßnahmen NNP cord-006856-b1w25ob5 332 26 ist ist NNP cord-006856-b1w25ob5 332 27 . . . cord-006856-b1w25ob5 333 1 Ischämiezeiten Ischämiezeiten NNP cord-006856-b1w25ob5 333 2 sind sind NNP cord-006856-b1w25ob5 334 1 ebenso ebenso NNP cord-006856-b1w25ob5 334 2 angestiegen angestiegen NNP cord-006856-b1w25ob5 334 3 ( ( -LRB- cord-006856-b1w25ob5 335 1 129,3 129,3 CD cord-006856-b1w25ob5 335 2 ± ± CD cord-006856-b1w25ob5 335 3 49,8 49,8 CD cord-006856-b1w25ob5 335 4 vs. vs. IN cord-006856-b1w25ob5 335 5 190 190 CD cord-006856-b1w25ob5 335 6 , , , cord-006856-b1w25ob5 335 7 0 0 CD cord-006856-b1w25ob5 336 1 ± ± NNP cord-006856-b1w25ob5 336 2 49,2 49,2 CD cord-006856-b1w25ob5 336 3 , , , cord-006856-b1w25ob5 336 4 P p NN cord-006856-b1w25ob5 336 5 < < XX cord-006856-b1w25ob5 336 6 0,01 0,01 NN cord-006856-b1w25ob5 336 7 ) ) -RRB- cord-006856-b1w25ob5 337 1 wie wie UH cord-006856-b1w25ob5 337 2 die die VB cord-006856-b1w25ob5 338 1 Liegezeiten Liegezeiten NNP cord-006856-b1w25ob5 338 2 auf auf NNP cord-006856-b1w25ob5 338 3 der der NN cord-006856-b1w25ob5 338 4 Intensivstation Intensivstation NNP cord-006856-b1w25ob5 338 5 ( ( -LRB- cord-006856-b1w25ob5 338 6 4,7 4,7 CD cord-006856-b1w25ob5 338 7 ± ± CD cord-006856-b1w25ob5 338 8 5,7 5,7 CD cord-006856-b1w25ob5 338 9 vs. vs. FW cord-006856-b1w25ob5 338 10 7,6 7,6 CD cord-006856-b1w25ob5 338 11 ± ± NNP cord-006856-b1w25ob5 338 12 7,7 7,7 CD cord-006856-b1w25ob5 338 13 , , , cord-006856-b1w25ob5 338 14 P p NN cord-006856-b1w25ob5 338 15 < < XX cord-006856-b1w25ob5 338 16 0,01 0,01 NN cord-006856-b1w25ob5 338 17 ) ) -RRB- cord-006856-b1w25ob5 338 18 . . . cord-006856-b1w25ob5 339 1 Dies die VBZ cord-006856-b1w25ob5 339 2 ist ist NNP cord-006856-b1w25ob5 340 1 ein ein NNP cord-006856-b1w25ob5 340 2 klares klares NNP cord-006856-b1w25ob5 341 1 Indiz Indiz NNP cord-006856-b1w25ob5 341 2 dafür dafür NNP cord-006856-b1w25ob5 341 3 , , , cord-006856-b1w25ob5 341 4 dass dass NNP cord-006856-b1w25ob5 341 5 heute heute NNP cord-006856-b1w25ob5 341 6 ältere ältere NNP cord-006856-b1w25ob5 341 7 , , , cord-006856-b1w25ob5 341 8 kränkere kränkere NNP cord-006856-b1w25ob5 341 9 und und XX cord-006856-b1w25ob5 342 1 komplexere komplexere NNP cord-006856-b1w25ob5 342 2 Patienten Patienten NNP cord-006856-b1w25ob5 342 3 transplantiert transplantiert NNP cord-006856-b1w25ob5 342 4 werden werden NNP cord-006856-b1w25ob5 342 5 . . . cord-006856-b1w25ob5 343 1 Diese Diese NNP cord-006856-b1w25ob5 343 2 Veränderungen Veränderungen NNP cord-006856-b1w25ob5 343 3 sind sind NNP cord-006856-b1w25ob5 344 1 international international NNP cord-006856-b1w25ob5 344 2 bei bei NNP cord-006856-b1w25ob5 344 3 allen allen NNP cord-006856-b1w25ob5 345 1 Zentren Zentren NNP cord-006856-b1w25ob5 345 2 zu zu CC cord-006856-b1w25ob5 345 3 be be VB cord-006856-b1w25ob5 345 4 - - HYPH cord-006856-b1w25ob5 345 5 obachten obachten JJ cord-006856-b1w25ob5 345 6 . . . cord-006856-b1w25ob5 346 1 Dies die VBZ cord-006856-b1w25ob5 346 2 hat hat NN cord-006856-b1w25ob5 346 3 dazu dazu NN cord-006856-b1w25ob5 346 4 geführt geführt NN cord-006856-b1w25ob5 346 5 , , , cord-006856-b1w25ob5 346 6 dass dass NNP cord-006856-b1w25ob5 346 7 mit mit NNP cord-006856-b1w25ob5 346 8 der der NNP cord-006856-b1w25ob5 346 9 zunehmenden zunehmenden NNP cord-006856-b1w25ob5 347 1 Erfahrung Erfahrung NNP cord-006856-b1w25ob5 348 1 und und IN cord-006856-b1w25ob5 348 2 verbessertem verbessertem NNP cord-006856-b1w25ob5 348 3 Überleben Überleben NNP cord-006856-b1w25ob5 348 4 die die VBP cord-006856-b1w25ob5 349 1 Nachbeobachtungszeit Nachbeobachtungszeit NNP cord-006856-b1w25ob5 349 2 der der NNP cord-006856-b1w25ob5 349 3 Patienten Patienten NNP cord-006856-b1w25ob5 350 1 stark stark JJ cord-006856-b1w25ob5 350 2 gestiegen gestiegen NNP cord-006856-b1w25ob5 350 3 ist ist NNP cord-006856-b1w25ob5 350 4 und und IN cord-006856-b1w25ob5 350 5 damit damit NNP cord-006856-b1w25ob5 350 6 die die VBP cord-006856-b1w25ob5 350 7 Behandlung Behandlung NNP cord-006856-b1w25ob5 350 8 dieser dieser NNP cord-006856-b1w25ob5 351 1 Patienten Patienten NNP cord-006856-b1w25ob5 351 2 kostenintensiver kostenintensiver NN cord-006856-b1w25ob5 351 3 geworden geworden NNP cord-006856-b1w25ob5 351 4 ist ist NNP cord-006856-b1w25ob5 351 5 , , , cord-006856-b1w25ob5 351 6 was be VBD cord-006856-b1w25ob5 351 7 aber aber NNP cord-006856-b1w25ob5 351 8 mit mit NNP cord-006856-b1w25ob5 351 9 der der NNP cord-006856-b1w25ob5 351 10 guten guten NNP cord-006856-b1w25ob5 351 11 Lebensqualität Lebensqualität NNPS cord-006856-b1w25ob5 351 12 der der VBP cord-006856-b1w25ob5 351 13 herztransplantierten herztransplantierten NNP cord-006856-b1w25ob5 352 1 Patienten Patienten NNP cord-006856-b1w25ob5 352 2 zu zu XX cord-006856-b1w25ob5 353 1 rechtfertigen rechtfertigen NNP cord-006856-b1w25ob5 353 2 ist ist NNP cord-006856-b1w25ob5 353 3 . . . cord-006856-b1w25ob5 354 1 V18 v18 JJ cord-006856-b1w25ob5 354 2 Neoplastic neoplastic JJ cord-006856-b1w25ob5 354 3 diseases disease NNS cord-006856-b1w25ob5 354 4 after after IN cord-006856-b1w25ob5 354 5 heart heart NN cord-006856-b1w25ob5 354 6 transplantation transplantation NN cord-006856-b1w25ob5 354 7 : : : cord-006856-b1w25ob5 355 1 A a DT cord-006856-b1w25ob5 355 2 retrospective retrospective JJ cord-006856-b1w25ob5 355 3 study study NN cord-006856-b1w25ob5 355 4 D. D. NNP cord-006856-b1w25ob5 355 5 Kammerstätter Kammerstätter NNP cord-006856-b1w25ob5 355 6 , , , cord-006856-b1w25ob5 355 7 A. A. NNP cord-006856-b1w25ob5 355 8 Aliabadi Aliabadi NNP cord-006856-b1w25ob5 355 9 , , , cord-006856-b1w25ob5 355 10 J. J. NNP cord-006856-b1w25ob5 355 11 Ankersmit Ankersmit NNP cord-006856-b1w25ob5 355 12 , , , cord-006856-b1w25ob5 355 13 D. D. NNP cord-006856-b1w25ob5 355 14 Dunkler Dunkler NNP cord-006856-b1w25ob5 355 15 , , , cord-006856-b1w25ob5 355 16 G. G. NNP cord-006856-b1w25ob5 355 17 Wieselthaler Wieselthaler NNP cord-006856-b1w25ob5 355 18 , , , cord-006856-b1w25ob5 355 19 E. E. NNP cord-006856-b1w25ob5 355 20 Wolner Wolner NNP cord-006856-b1w25ob5 355 21 , , , cord-006856-b1w25ob5 355 22 M. M. NNP cord-006856-b1w25ob5 355 23 Grimm Grimm NNP cord-006856-b1w25ob5 355 24 , , , cord-006856-b1w25ob5 356 1 A. A. NNP cord-006856-b1w25ob5 356 2 Zuckermann Zuckermann NNP cord-006856-b1w25ob5 356 3 Klinische Klinische NNP cord-006856-b1w25ob5 356 4 Abteilung Abteilung NNP cord-006856-b1w25ob5 356 5 für für IN cord-006856-b1w25ob5 356 6 Herz Herz NNP cord-006856-b1w25ob5 356 7 - - HYPH cord-006856-b1w25ob5 356 8 Thoraxchirurgie Thoraxchirurgie NNP cord-006856-b1w25ob5 356 9 , , , cord-006856-b1w25ob5 356 10 Universitätsklinik Universitätsklinik NNP cord-006856-b1w25ob5 356 11 für für IN cord-006856-b1w25ob5 356 12 Chirurgie Chirurgie NNP cord-006856-b1w25ob5 356 13 , , , cord-006856-b1w25ob5 357 1 Medizinische Medizinische NNP cord-006856-b1w25ob5 357 2 Universität Universität NNP cord-006856-b1w25ob5 357 3 Wien Wien NNP cord-006856-b1w25ob5 357 4 , , , cord-006856-b1w25ob5 357 5 Wien Wien NNP cord-006856-b1w25ob5 357 6 , , , cord-006856-b1w25ob5 357 7 Österreich Österreich NNP cord-006856-b1w25ob5 357 8 Background Background NNP cord-006856-b1w25ob5 357 9 . . . cord-006856-b1w25ob5 358 1 Prolonged prolonged JJ cord-006856-b1w25ob5 358 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 358 3 after after IN cord-006856-b1w25ob5 358 4 solidorgan solidorgan JJ cord-006856-b1w25ob5 358 5 transplantation transplantation NN cord-006856-b1w25ob5 358 6 is be VBZ cord-006856-b1w25ob5 358 7 associated associate VBN cord-006856-b1w25ob5 358 8 with with IN cord-006856-b1w25ob5 358 9 an an DT cord-006856-b1w25ob5 358 10 increased increase VBN cord-006856-b1w25ob5 358 11 risk risk NN cord-006856-b1w25ob5 358 12 for for IN cord-006856-b1w25ob5 358 13 development development NN cord-006856-b1w25ob5 358 14 of of IN cord-006856-b1w25ob5 358 15 neoplasms neoplasm NNS cord-006856-b1w25ob5 358 16 . . . cord-006856-b1w25ob5 359 1 The the DT cord-006856-b1w25ob5 359 2 purpose purpose NN cord-006856-b1w25ob5 359 3 of of IN cord-006856-b1w25ob5 359 4 this this DT cord-006856-b1w25ob5 359 5 analysis analysis NN cord-006856-b1w25ob5 359 6 was be VBD cord-006856-b1w25ob5 359 7 to to TO cord-006856-b1w25ob5 359 8 investigate investigate VB cord-006856-b1w25ob5 359 9 neoplasm neoplasm NN cord-006856-b1w25ob5 359 10 incidence incidence NN cord-006856-b1w25ob5 359 11 and and CC cord-006856-b1w25ob5 359 12 outcome outcome NN cord-006856-b1w25ob5 359 13 in in IN cord-006856-b1w25ob5 359 14 patients patient NNS cord-006856-b1w25ob5 359 15 with with IN cord-006856-b1w25ob5 359 16 induction induction NN cord-006856-b1w25ob5 359 17 therapy therapy NN cord-006856-b1w25ob5 359 18 . . . cord-006856-b1w25ob5 360 1 Methods method NNS cord-006856-b1w25ob5 360 2 . . . cord-006856-b1w25ob5 361 1 921 921 CD cord-006856-b1w25ob5 361 2 cardiac cardiac JJ cord-006856-b1w25ob5 361 3 recipients recipient NNS cord-006856-b1w25ob5 361 4 were be VBD cord-006856-b1w25ob5 361 5 included include VBN cord-006856-b1w25ob5 361 6 in in IN cord-006856-b1w25ob5 361 7 this this DT cord-006856-b1w25ob5 361 8 retrospective retrospective JJ cord-006856-b1w25ob5 361 9 analysis analysis NN cord-006856-b1w25ob5 361 10 . . . cord-006856-b1w25ob5 362 1 All all DT cord-006856-b1w25ob5 362 2 patients patient NNS cord-006856-b1w25ob5 362 3 received receive VBD cord-006856-b1w25ob5 362 4 antibody antibody NN cord-006856-b1w25ob5 362 5 induction induction NN cord-006856-b1w25ob5 362 6 therapy therapy NN cord-006856-b1w25ob5 362 7 with with IN cord-006856-b1w25ob5 362 8 either either DT cord-006856-b1w25ob5 362 9 polyclonal polyclonal JJ cord-006856-b1w25ob5 362 10 - - HYPH cord-006856-b1w25ob5 362 11 ATG ATG NNP cord-006856-b1w25ob5 362 12 or or CC cord-006856-b1w25ob5 362 13 monoclonal monoclonal JJ cord-006856-b1w25ob5 362 14 antibodies antibody NNS cord-006856-b1w25ob5 362 15 . . . cord-006856-b1w25ob5 363 1 Neoplasms neoplasm NNS cord-006856-b1w25ob5 363 2 were be VBD cord-006856-b1w25ob5 363 3 devided devide VBN cord-006856-b1w25ob5 363 4 into into IN cord-006856-b1w25ob5 363 5 3 3 CD cord-006856-b1w25ob5 363 6 groups group NNS cord-006856-b1w25ob5 363 7 : : : cord-006856-b1w25ob5 363 8 ( ( -LRB- cord-006856-b1w25ob5 363 9 1 1 LS cord-006856-b1w25ob5 363 10 ) ) -RRB- cord-006856-b1w25ob5 363 11 skin skin NN cord-006856-b1w25ob5 363 12 cancer cancer NN cord-006856-b1w25ob5 363 13 , , , cord-006856-b1w25ob5 363 14 ( ( -LRB- cord-006856-b1w25ob5 363 15 2 2 LS cord-006856-b1w25ob5 363 16 ) ) -RRB- cord-006856-b1w25ob5 363 17 PTLD PTLD NNP cord-006856-b1w25ob5 363 18 , , , cord-006856-b1w25ob5 363 19 ( ( -LRB- cord-006856-b1w25ob5 363 20 3 3 CD cord-006856-b1w25ob5 363 21 ) ) -RRB- cord-006856-b1w25ob5 363 22 other other JJ cord-006856-b1w25ob5 363 23 neoplasms neoplasm NNS cord-006856-b1w25ob5 363 24 . . . cord-006856-b1w25ob5 364 1 Overall overall JJ cord-006856-b1w25ob5 364 2 incidence incidence NN cord-006856-b1w25ob5 364 3 of of IN cord-006856-b1w25ob5 364 4 neoplasms neoplasm NNS cord-006856-b1w25ob5 364 5 , , , cord-006856-b1w25ob5 364 6 patient patient JJ cord-006856-b1w25ob5 364 7 survival survival NN cord-006856-b1w25ob5 364 8 after after IN cord-006856-b1w25ob5 364 9 diagnosis diagnosis NN cord-006856-b1w25ob5 364 10 of of IN cord-006856-b1w25ob5 364 11 neoplasms neoplasm NNS cord-006856-b1w25ob5 364 12 were be VBD cord-006856-b1w25ob5 364 13 analysed analyse VBN cord-006856-b1w25ob5 364 14 by by IN cord-006856-b1w25ob5 364 15 the the DT cord-006856-b1w25ob5 364 16 Kaplan Kaplan NNP cord-006856-b1w25ob5 364 17 - - HYPH cord-006856-b1w25ob5 364 18 Meier Meier NNP cord-006856-b1w25ob5 364 19 method method NN cord-006856-b1w25ob5 364 20 . . . cord-006856-b1w25ob5 365 1 Results result NNS cord-006856-b1w25ob5 365 2 . . . cord-006856-b1w25ob5 366 1 A a DT cord-006856-b1w25ob5 366 2 total total NN cord-006856-b1w25ob5 366 3 of of IN cord-006856-b1w25ob5 366 4 143 143 CD cord-006856-b1w25ob5 366 5 tumors tumor NNS cord-006856-b1w25ob5 366 6 were be VBD cord-006856-b1w25ob5 366 7 diagnosed diagnose VBN cord-006856-b1w25ob5 366 8 at at IN cord-006856-b1w25ob5 366 9 a a DT cord-006856-b1w25ob5 366 10 mean mean JJ cord-006856-b1w25ob5 366 11 follow follow NN cord-006856-b1w25ob5 366 12 - - HYPH cord-006856-b1w25ob5 366 13 up up NN cord-006856-b1w25ob5 366 14 of of IN cord-006856-b1w25ob5 366 15 59.6 59.6 CD cord-006856-b1w25ob5 366 16 ± ± CD cord-006856-b1w25ob5 366 17 51.2 51.2 CD cord-006856-b1w25ob5 366 18 months month NNS cord-006856-b1w25ob5 366 19 after after IN cord-006856-b1w25ob5 366 20 cardiac cardiac JJ cord-006856-b1w25ob5 366 21 transplantation transplantation NN cord-006856-b1w25ob5 366 22 . . . cord-006856-b1w25ob5 367 1 Freedom freedom NN cord-006856-b1w25ob5 367 2 from from IN cord-006856-b1w25ob5 367 3 neoplasms neoplasm NNS cord-006856-b1w25ob5 367 4 was be VBD cord-006856-b1w25ob5 367 5 96.7 96.7 CD cord-006856-b1w25ob5 367 6 % % NN cord-006856-b1w25ob5 367 7 , , , cord-006856-b1w25ob5 367 8 86.6 86.6 CD cord-006856-b1w25ob5 367 9 % % NN cord-006856-b1w25ob5 367 10 , , , cord-006856-b1w25ob5 367 11 and and CC cord-006856-b1w25ob5 367 12 71.5 71.5 CD cord-006856-b1w25ob5 367 13 % % NN cord-006856-b1w25ob5 367 14 after after IN cord-006856-b1w25ob5 367 15 1- 1- CD cord-006856-b1w25ob5 367 16 , , , cord-006856-b1w25ob5 367 17 5- 5- NNP cord-006856-b1w25ob5 367 18 , , , cord-006856-b1w25ob5 367 19 and and CC cord-006856-b1w25ob5 367 20 10-year 10-year CD cord-006856-b1w25ob5 367 21 respectively respectively RB cord-006856-b1w25ob5 367 22 . . . cord-006856-b1w25ob5 368 1 5-year 5-year CD cord-006856-b1w25ob5 368 2 survival survival NN cord-006856-b1w25ob5 368 3 after after IN cord-006856-b1w25ob5 368 4 diagnosis diagnosis NN cord-006856-b1w25ob5 368 5 of of IN cord-006856-b1w25ob5 368 6 tumor tumor NN cord-006856-b1w25ob5 368 7 was be VBD cord-006856-b1w25ob5 368 8 50.3 50.3 CD cord-006856-b1w25ob5 368 9 % % NN cord-006856-b1w25ob5 368 10 . . . cord-006856-b1w25ob5 369 1 65 65 CD cord-006856-b1w25ob5 369 2 patients patient NNS cord-006856-b1w25ob5 369 3 developed develop VBD cord-006856-b1w25ob5 369 4 skin skin NN cord-006856-b1w25ob5 369 5 cancers cancer NNS cord-006856-b1w25ob5 369 6 after after IN cord-006856-b1w25ob5 369 7 62 62 CD cord-006856-b1w25ob5 369 8 ± ± CD cord-006856-b1w25ob5 369 9 40.6 40.6 CD cord-006856-b1w25ob5 369 10 months month NNS cord-006856-b1w25ob5 369 11 . . . cord-006856-b1w25ob5 370 1 1-and 1-and CD cord-006856-b1w25ob5 370 2 5-year 5-year CD cord-006856-b1w25ob5 370 3 survival survival NN cord-006856-b1w25ob5 370 4 after after IN cord-006856-b1w25ob5 370 5 diagnosis diagnosis NN cord-006856-b1w25ob5 370 6 was be VBD cord-006856-b1w25ob5 370 7 96 96 CD cord-006856-b1w25ob5 370 8 % % NN cord-006856-b1w25ob5 370 9 and and CC cord-006856-b1w25ob5 370 10 71 71 CD cord-006856-b1w25ob5 370 11 % % NN cord-006856-b1w25ob5 370 12 respectively respectively RB cord-006856-b1w25ob5 370 13 . . . cord-006856-b1w25ob5 371 1 There there EX cord-006856-b1w25ob5 371 2 were be VBD cord-006856-b1w25ob5 371 3 7 7 CD cord-006856-b1w25ob5 371 4 tumor tumor NN cord-006856-b1w25ob5 371 5 - - HYPH cord-006856-b1w25ob5 371 6 related relate VBN cord-006856-b1w25ob5 371 7 deaths death NNS cord-006856-b1w25ob5 371 8 in in IN cord-006856-b1w25ob5 371 9 this this DT cord-006856-b1w25ob5 371 10 group group NN cord-006856-b1w25ob5 371 11 . . . cord-006856-b1w25ob5 372 1 19 19 CD cord-006856-b1w25ob5 372 2 patients patient NNS cord-006856-b1w25ob5 372 3 developed develop VBD cord-006856-b1w25ob5 372 4 PTLD PTLD NNP cord-006856-b1w25ob5 372 5 40.7 40.7 CD cord-006856-b1w25ob5 372 6 ± ± CD cord-006856-b1w25ob5 372 7 33.7 33.7 CD cord-006856-b1w25ob5 372 8 months month NNS cord-006856-b1w25ob5 372 9 after after IN cord-006856-b1w25ob5 372 10 transplantation transplantation NN cord-006856-b1w25ob5 372 11 . . . cord-006856-b1w25ob5 373 1 1-and 1-and CD cord-006856-b1w25ob5 373 2 5-year 5-year CD cord-006856-b1w25ob5 373 3 survival survival NN cord-006856-b1w25ob5 373 4 was be VBD cord-006856-b1w25ob5 373 5 63 63 CD cord-006856-b1w25ob5 373 6 % % NN cord-006856-b1w25ob5 373 7 and and CC cord-006856-b1w25ob5 373 8 40 40 CD cord-006856-b1w25ob5 373 9 % % NN cord-006856-b1w25ob5 373 10 with with IN cord-006856-b1w25ob5 373 11 12 12 CD cord-006856-b1w25ob5 373 12 deaths death NNS cord-006856-b1w25ob5 373 13 associated associate VBN cord-006856-b1w25ob5 373 14 with with IN cord-006856-b1w25ob5 373 15 the the DT cord-006856-b1w25ob5 373 16 neoplasm neoplasm NN cord-006856-b1w25ob5 373 17 . . . cord-006856-b1w25ob5 374 1 In in IN cord-006856-b1w25ob5 374 2 the the DT cord-006856-b1w25ob5 374 3 third third JJ cord-006856-b1w25ob5 374 4 group group NN cord-006856-b1w25ob5 374 5 , , , cord-006856-b1w25ob5 374 6 a a DT cord-006856-b1w25ob5 374 7 total total NN cord-006856-b1w25ob5 374 8 of of IN cord-006856-b1w25ob5 374 9 59 59 CD cord-006856-b1w25ob5 374 10 patients patient NNS cord-006856-b1w25ob5 374 11 were be VBD cord-006856-b1w25ob5 374 12 included include VBN cord-006856-b1w25ob5 374 13 . . . cord-006856-b1w25ob5 375 1 This this DT cord-006856-b1w25ob5 375 2 group group NN cord-006856-b1w25ob5 375 3 consisted consist VBD cord-006856-b1w25ob5 375 4 of of IN cord-006856-b1w25ob5 375 5 lung lung NN cord-006856-b1w25ob5 375 6 cancer cancer NN cord-006856-b1w25ob5 375 7 ( ( -LRB- cord-006856-b1w25ob5 375 8 n n NN cord-006856-b1w25ob5 375 9 = = SYM cord-006856-b1w25ob5 375 10 17 17 CD cord-006856-b1w25ob5 375 11 ) ) -RRB- cord-006856-b1w25ob5 375 12 , , , cord-006856-b1w25ob5 375 13 abdominal abdominal JJ cord-006856-b1w25ob5 375 14 cancer cancer NN cord-006856-b1w25ob5 375 15 ( ( -LRB- cord-006856-b1w25ob5 375 16 n n NN cord-006856-b1w25ob5 375 17 = = SYM cord-006856-b1w25ob5 375 18 15 15 CD cord-006856-b1w25ob5 375 19 ) ) -RRB- cord-006856-b1w25ob5 375 20 , , , cord-006856-b1w25ob5 375 21 urogenital urogenital JJ cord-006856-b1w25ob5 375 22 cancer cancer NN cord-006856-b1w25ob5 375 23 ( ( -LRB- cord-006856-b1w25ob5 375 24 n n NN cord-006856-b1w25ob5 375 25 = = SYM cord-006856-b1w25ob5 375 26 7 7 CD cord-006856-b1w25ob5 375 27 ) ) -RRB- cord-006856-b1w25ob5 375 28 , , , cord-006856-b1w25ob5 375 29 and and CC cord-006856-b1w25ob5 375 30 other other JJ cord-006856-b1w25ob5 375 31 tumors tumor NNS cord-006856-b1w25ob5 375 32 ( ( -LRB- cord-006856-b1w25ob5 375 33 n n NN cord-006856-b1w25ob5 375 34 = = SYM cord-006856-b1w25ob5 375 35 20 20 CD cord-006856-b1w25ob5 375 36 ) ) -RRB- cord-006856-b1w25ob5 375 37 . . . cord-006856-b1w25ob5 376 1 Neoplasms neoplasm NNS cord-006856-b1w25ob5 376 2 were be VBD cord-006856-b1w25ob5 376 3 diagnosed diagnose VBN cord-006856-b1w25ob5 376 4 at at IN cord-006856-b1w25ob5 376 5 an an DT cord-006856-b1w25ob5 376 6 average average JJ cord-006856-b1w25ob5 376 7 follow follow NN cord-006856-b1w25ob5 376 8 - - HYPH cord-006856-b1w25ob5 376 9 up up NN cord-006856-b1w25ob5 376 10 of of IN cord-006856-b1w25ob5 376 11 53.5 53.5 CD cord-006856-b1w25ob5 376 12 ± ± CD cord-006856-b1w25ob5 376 13 42.7 42.7 CD cord-006856-b1w25ob5 376 14 months month NNS cord-006856-b1w25ob5 376 15 . . . cord-006856-b1w25ob5 377 1 1-year 1-year CD cord-006856-b1w25ob5 377 2 and and CC cord-006856-b1w25ob5 377 3 5year 5year CD cord-006856-b1w25ob5 377 4 survival survival NN cord-006856-b1w25ob5 377 5 was be VBD cord-006856-b1w25ob5 377 6 57 57 CD cord-006856-b1w25ob5 377 7 % % NN cord-006856-b1w25ob5 377 8 and and CC cord-006856-b1w25ob5 377 9 25 25 CD cord-006856-b1w25ob5 377 10 % % NN cord-006856-b1w25ob5 377 11 . . . cord-006856-b1w25ob5 378 1 31 31 CD cord-006856-b1w25ob5 378 2 deaths death NNS cord-006856-b1w25ob5 378 3 were be VBD cord-006856-b1w25ob5 378 4 associated associate VBN cord-006856-b1w25ob5 378 5 with with IN cord-006856-b1w25ob5 378 6 tumor tumor NN cord-006856-b1w25ob5 378 7 . . . cord-006856-b1w25ob5 379 1 Conclusions conclusion NNS cord-006856-b1w25ob5 379 2 . . . cord-006856-b1w25ob5 380 1 Although although IN cord-006856-b1w25ob5 380 2 all all DT cord-006856-b1w25ob5 380 3 patients patient NNS cord-006856-b1w25ob5 380 4 received receive VBD cord-006856-b1w25ob5 380 5 antibody antibody NN cord-006856-b1w25ob5 380 6 induction induction NN cord-006856-b1w25ob5 380 7 therapy therapy NN cord-006856-b1w25ob5 380 8 , , , cord-006856-b1w25ob5 380 9 overall overall JJ cord-006856-b1w25ob5 380 10 incidence incidence NN cord-006856-b1w25ob5 380 11 of of IN cord-006856-b1w25ob5 380 12 neoplasms neoplasm NNS cord-006856-b1w25ob5 380 13 was be VBD cord-006856-b1w25ob5 380 14 comparable comparable JJ cord-006856-b1w25ob5 380 15 to to IN cord-006856-b1w25ob5 380 16 centers center NNS cord-006856-b1w25ob5 380 17 using use VBG cord-006856-b1w25ob5 380 18 no no DT cord-006856-b1w25ob5 380 19 induction induction NN cord-006856-b1w25ob5 380 20 therapy therapy NN cord-006856-b1w25ob5 380 21 . . . cord-006856-b1w25ob5 381 1 Especially especially RB cord-006856-b1w25ob5 381 2 incidence incidence NN cord-006856-b1w25ob5 381 3 of of IN cord-006856-b1w25ob5 381 4 PTLD PTLD NNP cord-006856-b1w25ob5 381 5 was be VBD cord-006856-b1w25ob5 381 6 low low JJ cord-006856-b1w25ob5 381 7 . . . cord-006856-b1w25ob5 382 1 As as IN cord-006856-b1w25ob5 382 2 long long JJ cord-006856-b1w25ob5 382 3 - - HYPH cord-006856-b1w25ob5 382 4 term term NN cord-006856-b1w25ob5 382 5 survival survival NN cord-006856-b1w25ob5 382 6 after after IN cord-006856-b1w25ob5 382 7 cardiac cardiac JJ cord-006856-b1w25ob5 382 8 transplantation transplantation NN cord-006856-b1w25ob5 382 9 increases increase VBZ cord-006856-b1w25ob5 382 10 steadily steadily RB cord-006856-b1w25ob5 382 11 and and CC cord-006856-b1w25ob5 382 12 the the DT cord-006856-b1w25ob5 382 13 risk risk NN cord-006856-b1w25ob5 382 14 of of IN cord-006856-b1w25ob5 382 15 cancer cancer NN cord-006856-b1w25ob5 382 16 increases increase NNS cord-006856-b1w25ob5 382 17 continuously continuously RB cord-006856-b1w25ob5 382 18 , , , cord-006856-b1w25ob5 382 19 patients patient NNS cord-006856-b1w25ob5 382 20 in in IN cord-006856-b1w25ob5 382 21 long long JJ cord-006856-b1w25ob5 382 22 - - HYPH cord-006856-b1w25ob5 382 23 term term NN cord-006856-b1w25ob5 382 24 follow follow NN cord-006856-b1w25ob5 382 25 - - HYPH cord-006856-b1w25ob5 382 26 up up NN cord-006856-b1w25ob5 382 27 should should MD cord-006856-b1w25ob5 382 28 be be VB cord-006856-b1w25ob5 382 29 checked check VBN cord-006856-b1w25ob5 382 30 for for IN cord-006856-b1w25ob5 382 31 malignant malignant JJ cord-006856-b1w25ob5 382 32 diseases disease NNS cord-006856-b1w25ob5 382 33 on on IN cord-006856-b1w25ob5 382 34 a a DT cord-006856-b1w25ob5 382 35 routine routine JJ cord-006856-b1w25ob5 382 36 basis basis NN cord-006856-b1w25ob5 382 37 . . . cord-006856-b1w25ob5 383 1 Background background NN cord-006856-b1w25ob5 383 2 . . . cord-006856-b1w25ob5 384 1 While while IN cord-006856-b1w25ob5 384 2 the the DT cord-006856-b1w25ob5 384 3 predictive predictive JJ cord-006856-b1w25ob5 384 4 value value NN cord-006856-b1w25ob5 384 5 of of IN cord-006856-b1w25ob5 384 6 N n CD cord-006856-b1w25ob5 384 7 - - HYPH cord-006856-b1w25ob5 384 8 terminal terminal NN cord-006856-b1w25ob5 384 9 pro pro JJ cord-006856-b1w25ob5 384 10 - - JJ cord-006856-b1w25ob5 384 11 B b NN cord-006856-b1w25ob5 384 12 - - HYPH cord-006856-b1w25ob5 384 13 type type NN cord-006856-b1w25ob5 384 14 natriuretic natriuretic JJ cord-006856-b1w25ob5 384 15 peptide peptide NN cord-006856-b1w25ob5 384 16 ( ( -LRB- cord-006856-b1w25ob5 384 17 NT NT NNP cord-006856-b1w25ob5 384 18 pro pro JJ cord-006856-b1w25ob5 384 19 - - JJ cord-006856-b1w25ob5 384 20 BNP BNP NNP cord-006856-b1w25ob5 384 21 ) ) -RRB- cord-006856-b1w25ob5 384 22 in in IN cord-006856-b1w25ob5 384 23 nontransplant nontransplant JJ cord-006856-b1w25ob5 384 24 cardiac cardiac JJ cord-006856-b1w25ob5 384 25 patients patient NNS cord-006856-b1w25ob5 384 26 is be VBZ cord-006856-b1w25ob5 384 27 well well RB cord-006856-b1w25ob5 384 28 recognized recognize VBN cord-006856-b1w25ob5 384 29 , , , cord-006856-b1w25ob5 384 30 its -PRON- PRP$ cord-006856-b1w25ob5 384 31 value value NN cord-006856-b1w25ob5 384 32 in in IN cord-006856-b1w25ob5 384 33 heart heart NN cord-006856-b1w25ob5 384 34 transplantation transplantation NN cord-006856-b1w25ob5 384 35 ( ( -LRB- cord-006856-b1w25ob5 384 36 HTx HTx NNS cord-006856-b1w25ob5 384 37 ) ) -RRB- cord-006856-b1w25ob5 384 38 is be VBZ cord-006856-b1w25ob5 384 39 incompletely incompletely RB cord-006856-b1w25ob5 384 40 understood understand VBN cord-006856-b1w25ob5 384 41 . . . cord-006856-b1w25ob5 385 1 Certain certain JJ cord-006856-b1w25ob5 385 2 graft graft NN cord-006856-b1w25ob5 385 3 factors factor NNS cord-006856-b1w25ob5 385 4 ( ( -LRB- cord-006856-b1w25ob5 385 5 e.g. e.g. RB cord-006856-b1w25ob5 385 6 , , , cord-006856-b1w25ob5 385 7 isolated isolate VBN cord-006856-b1w25ob5 385 8 diastolic diastolic JJ cord-006856-b1w25ob5 385 9 dysfunction dysfunction NN cord-006856-b1w25ob5 385 10 ) ) -RRB- cord-006856-b1w25ob5 385 11 may may MD cord-006856-b1w25ob5 385 12 affect affect VB cord-006856-b1w25ob5 385 13 both both DT cord-006856-b1w25ob5 385 14 , , , cord-006856-b1w25ob5 385 15 NT NT NNP cord-006856-b1w25ob5 385 16 pro pro JJ cord-006856-b1w25ob5 385 17 - - JJ cord-006856-b1w25ob5 385 18 BNP bnp JJ cord-006856-b1w25ob5 385 19 levels level NNS cord-006856-b1w25ob5 385 20 and and CC cord-006856-b1w25ob5 385 21 peak peak NN cord-006856-b1w25ob5 385 22 exercise exercise NN cord-006856-b1w25ob5 385 23 tolerance tolerance NN cord-006856-b1w25ob5 385 24 . . . cord-006856-b1w25ob5 386 1 We -PRON- PRP cord-006856-b1w25ob5 386 2 therefore therefore RB cord-006856-b1w25ob5 386 3 hypothesized hypothesize VBD cord-006856-b1w25ob5 386 4 a a DT cord-006856-b1w25ob5 386 5 relationship relationship NN cord-006856-b1w25ob5 386 6 between between IN cord-006856-b1w25ob5 386 7 these these DT cord-006856-b1w25ob5 386 8 variables variable NNS cord-006856-b1w25ob5 386 9 in in IN cord-006856-b1w25ob5 386 10 long long JJ cord-006856-b1w25ob5 386 11 - - HYPH cord-006856-b1w25ob5 386 12 term term NN cord-006856-b1w25ob5 386 13 HTx HTx NNS cord-006856-b1w25ob5 386 14 recipients recipient NNS cord-006856-b1w25ob5 386 15 . . . cord-006856-b1w25ob5 387 1 Methods method NNS cord-006856-b1w25ob5 387 2 . . . cord-006856-b1w25ob5 388 1 We -PRON- PRP cord-006856-b1w25ob5 388 2 measured measure VBD cord-006856-b1w25ob5 388 3 NT NT NNP cord-006856-b1w25ob5 388 4 pro pro JJ cord-006856-b1w25ob5 388 5 - - JJ cord-006856-b1w25ob5 388 6 BNP bnp JJ cord-006856-b1w25ob5 388 7 levels level NNS cord-006856-b1w25ob5 388 8 of of IN cord-006856-b1w25ob5 388 9 27 27 CD cord-006856-b1w25ob5 388 10 HTx HTx NNS cord-006856-b1w25ob5 388 11 patients patient NNS cord-006856-b1w25ob5 388 12 before before IN cord-006856-b1w25ob5 388 13 a a DT cord-006856-b1w25ob5 388 14 symptom symptom NN cord-006856-b1w25ob5 388 15 - - HYPH cord-006856-b1w25ob5 388 16 limited limit VBN cord-006856-b1w25ob5 388 17 upright upright JJ cord-006856-b1w25ob5 388 18 bicycle bicycle NN cord-006856-b1w25ob5 388 19 exercise exercise NN cord-006856-b1w25ob5 388 20 test test NN cord-006856-b1w25ob5 388 21 was be VBD cord-006856-b1w25ob5 388 22 performed perform VBN cord-006856-b1w25ob5 388 23 . . . cord-006856-b1w25ob5 389 1 Graft graft NN cord-006856-b1w25ob5 389 2 function function NN cord-006856-b1w25ob5 389 3 was be VBD cord-006856-b1w25ob5 389 4 stable stable JJ cord-006856-b1w25ob5 389 5 in in IN cord-006856-b1w25ob5 389 6 all all DT cord-006856-b1w25ob5 389 7 patients patient NNS cord-006856-b1w25ob5 389 8 and and CC cord-006856-b1w25ob5 389 9 there there EX cord-006856-b1w25ob5 389 10 were be VBD cord-006856-b1w25ob5 389 11 no no DT cord-006856-b1w25ob5 389 12 signs sign NNS cord-006856-b1w25ob5 389 13 of of IN cord-006856-b1w25ob5 389 14 rejection rejection NN cord-006856-b1w25ob5 389 15 . . . cord-006856-b1w25ob5 390 1 Patients patient NNS cord-006856-b1w25ob5 390 2 were be VBD cord-006856-b1w25ob5 390 3 divided divide VBN cord-006856-b1w25ob5 390 4 according accord VBG cord-006856-b1w25ob5 390 5 to to IN cord-006856-b1w25ob5 390 6 a a DT cord-006856-b1w25ob5 390 7 cut cut VB cord-006856-b1w25ob5 390 8 - - HYPH cord-006856-b1w25ob5 390 9 off off RP cord-006856-b1w25ob5 390 10 value value NN cord-006856-b1w25ob5 390 11 of of IN cord-006856-b1w25ob5 390 12 70 70 CD cord-006856-b1w25ob5 390 13 % % NN cord-006856-b1w25ob5 390 14 exercise exercise NN cord-006856-b1w25ob5 390 15 tolerance tolerance NN cord-006856-b1w25ob5 390 16 predicted predict VBD cord-006856-b1w25ob5 390 17 normal normal JJ cord-006856-b1w25ob5 390 18 into into IN cord-006856-b1w25ob5 390 19 " " `` cord-006856-b1w25ob5 390 20 low low JJ cord-006856-b1w25ob5 390 21 " " '' cord-006856-b1w25ob5 390 22 and and CC cord-006856-b1w25ob5 390 23 " " `` cord-006856-b1w25ob5 390 24 normal normal JJ cord-006856-b1w25ob5 390 25 " " '' cord-006856-b1w25ob5 390 26 HTx HTx NNS cord-006856-b1w25ob5 390 27 fitness fitness NN cord-006856-b1w25ob5 390 28 groups group NNS cord-006856-b1w25ob5 390 29 . . . cord-006856-b1w25ob5 391 1 Results result NNS cord-006856-b1w25ob5 391 2 . . . cord-006856-b1w25ob5 392 1 In in IN cord-006856-b1w25ob5 392 2 12 12 CD cord-006856-b1w25ob5 392 3 patients patient NNS cord-006856-b1w25ob5 392 4 ( ( -LRB- cord-006856-b1w25ob5 392 5 11 11 CD cord-006856-b1w25ob5 392 6 m m NNP cord-006856-b1w25ob5 392 7 , , , cord-006856-b1w25ob5 392 8 1 1 CD cord-006856-b1w25ob5 392 9 f f NN cord-006856-b1w25ob5 392 10 ; ; : cord-006856-b1w25ob5 392 11 57 57 CD cord-006856-b1w25ob5 392 12 ± ± CD cord-006856-b1w25ob5 392 13 10 10 CD cord-006856-b1w25ob5 392 14 years year NNS cord-006856-b1w25ob5 392 15 ; ; : cord-006856-b1w25ob5 392 16 6.5 6.5 CD cord-006856-b1w25ob5 392 17 ± ± CD cord-006856-b1w25ob5 392 18 4 4 CD cord-006856-b1w25ob5 392 19 years year NNS cord-006856-b1w25ob5 392 20 postHTx posthtx JJ cord-006856-b1w25ob5 392 21 ; ; : cord-006856-b1w25ob5 392 22 donor donor NN cord-006856-b1w25ob5 392 23 age age NN cord-006856-b1w25ob5 392 24 , , , cord-006856-b1w25ob5 392 25 36 36 CD cord-006856-b1w25ob5 392 26 ± ± CD cord-006856-b1w25ob5 392 27 10 10 CD cord-006856-b1w25ob5 392 28 years year NNS cord-006856-b1w25ob5 392 29 ; ; : cord-006856-b1w25ob5 392 30 BMI BMI NNP cord-006856-b1w25ob5 392 31 , , , cord-006856-b1w25ob5 392 32 28.6 28.6 CD cord-006856-b1w25ob5 392 33 ± ± CD cord-006856-b1w25ob5 392 34 2.8 2.8 CD cord-006856-b1w25ob5 392 35 kg kg NNS cord-006856-b1w25ob5 392 36 / / SYM cord-006856-b1w25ob5 392 37 m m NN cord-006856-b1w25ob5 392 38 2 2 CD cord-006856-b1w25ob5 392 39 ; ; , cord-006856-b1w25ob5 392 40 creatinine creatinine NN cord-006856-b1w25ob5 392 41 clearance clearance NN cord-006856-b1w25ob5 392 42 , , , cord-006856-b1w25ob5 392 43 42 42 CD cord-006856-b1w25ob5 392 44 ± ± CD cord-006856-b1w25ob5 392 45 10 10 CD cord-006856-b1w25ob5 393 1 ml ml NNP cord-006856-b1w25ob5 393 2 / / SYM cord-006856-b1w25ob5 393 3 min min NNP cord-006856-b1w25ob5 393 4 ) ) -RRB- cord-006856-b1w25ob5 393 5 peak peak NN cord-006856-b1w25ob5 393 6 exercise exercise NN cord-006856-b1w25ob5 393 7 tolerance tolerance NN cord-006856-b1w25ob5 393 8 was be VBD cord-006856-b1w25ob5 393 9 " " `` cord-006856-b1w25ob5 393 10 low low JJ cord-006856-b1w25ob5 393 11 " " '' cord-006856-b1w25ob5 393 12 ( ( -LRB- cord-006856-b1w25ob5 393 13 93 93 CD cord-006856-b1w25ob5 393 14 ± ± CD cord-006856-b1w25ob5 393 15 25 25 CD cord-006856-b1w25ob5 393 16 W W NNP cord-006856-b1w25ob5 393 17 ) ) -RRB- cord-006856-b1w25ob5 393 18 , , , cord-006856-b1w25ob5 393 19 while while IN cord-006856-b1w25ob5 393 20 in in IN cord-006856-b1w25ob5 393 21 15 15 CD cord-006856-b1w25ob5 393 22 patients patient NNS cord-006856-b1w25ob5 393 23 ( ( -LRB- cord-006856-b1w25ob5 393 24 11 11 CD cord-006856-b1w25ob5 393 25 m m NNP cord-006856-b1w25ob5 393 26 , , , cord-006856-b1w25ob5 393 27 4 4 CD cord-006856-b1w25ob5 393 28 f f NN cord-006856-b1w25ob5 393 29 ; ; : cord-006856-b1w25ob5 393 30 57 57 CD cord-006856-b1w25ob5 393 31 ± ± CD cord-006856-b1w25ob5 393 32 11 11 CD cord-006856-b1w25ob5 393 33 years year NNS cord-006856-b1w25ob5 393 34 ; ; : cord-006856-b1w25ob5 393 35 7.4 7.4 CD cord-006856-b1w25ob5 393 36 ± ± CD cord-006856-b1w25ob5 393 37 3.6 3.6 CD cord-006856-b1w25ob5 393 38 years year NNS cord-006856-b1w25ob5 393 39 postHTx posthtx JJ cord-006856-b1w25ob5 393 40 ; ; : cord-006856-b1w25ob5 393 41 donor donor NN cord-006856-b1w25ob5 393 42 age age NN cord-006856-b1w25ob5 393 43 , , , cord-006856-b1w25ob5 393 44 32 32 CD cord-006856-b1w25ob5 393 45 ± ± CD cord-006856-b1w25ob5 393 46 10 10 CD cord-006856-b1w25ob5 393 47 years year NNS cord-006856-b1w25ob5 393 48 ; ; : cord-006856-b1w25ob5 393 49 BMI BMI NNP cord-006856-b1w25ob5 393 50 , , , cord-006856-b1w25ob5 393 51 26.6 26.6 CD cord-006856-b1w25ob5 393 52 ± ± NNP cord-006856-b1w25ob5 393 53 2.7 2.7 CD cord-006856-b1w25ob5 393 54 kg kg NNP cord-006856-b1w25ob5 393 55 / / SYM cord-006856-b1w25ob5 393 56 m m NN cord-006856-b1w25ob5 393 57 2 2 CD cord-006856-b1w25ob5 393 58 ; ; , cord-006856-b1w25ob5 393 59 creatinine creatinine NN cord-006856-b1w25ob5 393 60 clearance clearance NN cord-006856-b1w25ob5 393 61 , , , cord-006856-b1w25ob5 393 62 42 42 CD cord-006856-b1w25ob5 393 63 ± ± NNP cord-006856-b1w25ob5 393 64 8 8 CD cord-006856-b1w25ob5 393 65 ml ml NN cord-006856-b1w25ob5 393 66 / / SYM cord-006856-b1w25ob5 393 67 min min NN cord-006856-b1w25ob5 393 68 ) ) -RRB- cord-006856-b1w25ob5 394 1 it -PRON- PRP cord-006856-b1w25ob5 394 2 was be VBD cord-006856-b1w25ob5 394 3 " " `` cord-006856-b1w25ob5 394 4 normal normal JJ cord-006856-b1w25ob5 394 5 " " '' cord-006856-b1w25ob5 394 6 ( ( -LRB- cord-006856-b1w25ob5 394 7 136 136 CD cord-006856-b1w25ob5 394 8 ± ± NNP cord-006856-b1w25ob5 394 9 37 37 CD cord-006856-b1w25ob5 394 10 W W NNP cord-006856-b1w25ob5 394 11 ) ) -RRB- cord-006856-b1w25ob5 394 12 . . . cord-006856-b1w25ob5 395 1 In in IN cord-006856-b1w25ob5 395 2 the the DT cord-006856-b1w25ob5 395 3 " " `` cord-006856-b1w25ob5 395 4 low low JJ cord-006856-b1w25ob5 395 5 " " '' cord-006856-b1w25ob5 395 6 HTx HTx NNS cord-006856-b1w25ob5 395 7 fitness fitness NN cord-006856-b1w25ob5 395 8 group group NN cord-006856-b1w25ob5 395 9 , , , cord-006856-b1w25ob5 395 10 NT NT NNP cord-006856-b1w25ob5 395 11 pro pro JJ cord-006856-b1w25ob5 395 12 - - JJ cord-006856-b1w25ob5 395 13 BNP bnp JJ cord-006856-b1w25ob5 395 14 levels level NNS cord-006856-b1w25ob5 395 15 were be VBD cord-006856-b1w25ob5 395 16 702 702 CD cord-006856-b1w25ob5 395 17 ± ± NNP cord-006856-b1w25ob5 395 18 778 778 CD cord-006856-b1w25ob5 395 19 pg pg NN cord-006856-b1w25ob5 395 20 / / SYM cord-006856-b1w25ob5 395 21 ml ml XX cord-006856-b1w25ob5 395 22 , , , cord-006856-b1w25ob5 395 23 in in IN cord-006856-b1w25ob5 395 24 the the DT cord-006856-b1w25ob5 395 25 " " `` cord-006856-b1w25ob5 395 26 normal normal JJ cord-006856-b1w25ob5 395 27 " " '' cord-006856-b1w25ob5 395 28 HTx HTx NNS cord-006856-b1w25ob5 395 29 fitness fitness NN cord-006856-b1w25ob5 395 30 group group NN cord-006856-b1w25ob5 395 31 , , , cord-006856-b1w25ob5 395 32 324 324 CD cord-006856-b1w25ob5 395 33 ± ± CD cord-006856-b1w25ob5 395 34 250 250 CD cord-006856-b1w25ob5 395 35 pg pg NN cord-006856-b1w25ob5 395 36 / / SYM cord-006856-b1w25ob5 395 37 ml ml NN cord-006856-b1w25ob5 396 1 ( ( -LRB- cord-006856-b1w25ob5 396 2 P p NN cord-006856-b1w25ob5 396 3 = = SYM cord-006856-b1w25ob5 396 4 0.08 0.08 CD cord-006856-b1w25ob5 396 5 between between IN cord-006856-b1w25ob5 396 6 groups group NNS cord-006856-b1w25ob5 396 7 ) ) -RRB- cord-006856-b1w25ob5 396 8 . . . cord-006856-b1w25ob5 397 1 Regression regression NN cord-006856-b1w25ob5 397 2 analysis analysis NN cord-006856-b1w25ob5 397 3 of of IN cord-006856-b1w25ob5 397 4 peak peak NN cord-006856-b1w25ob5 397 5 exercise exercise NN cord-006856-b1w25ob5 397 6 tolerance tolerance NN cord-006856-b1w25ob5 397 7 , , , cord-006856-b1w25ob5 397 8 achieved achieve VBN cord-006856-b1w25ob5 397 9 percentage percentage NN cord-006856-b1w25ob5 397 10 of of IN cord-006856-b1w25ob5 397 11 exercise exercise NN cord-006856-b1w25ob5 397 12 tolerance tolerance NN cord-006856-b1w25ob5 397 13 predicted predict VBD cord-006856-b1w25ob5 397 14 " " `` cord-006856-b1w25ob5 397 15 normal normal JJ cord-006856-b1w25ob5 397 16 " " '' cord-006856-b1w25ob5 397 17 , , , cord-006856-b1w25ob5 397 18 and and CC cord-006856-b1w25ob5 397 19 renal renal JJ cord-006856-b1w25ob5 397 20 function function NN cord-006856-b1w25ob5 397 21 with with IN cord-006856-b1w25ob5 397 22 NT NT NNP cord-006856-b1w25ob5 397 23 pro pro JJ cord-006856-b1w25ob5 397 24 - - JJ cord-006856-b1w25ob5 397 25 BNP bnp JJ cord-006856-b1w25ob5 397 26 levels level NNS cord-006856-b1w25ob5 397 27 failed fail VBD cord-006856-b1w25ob5 397 28 to to TO cord-006856-b1w25ob5 397 29 demonstrate demonstrate VB cord-006856-b1w25ob5 397 30 a a DT cord-006856-b1w25ob5 397 31 significant significant JJ cord-006856-b1w25ob5 397 32 relationship relationship NN cord-006856-b1w25ob5 397 33 . . . cord-006856-b1w25ob5 398 1 Conclusions conclusion NNS cord-006856-b1w25ob5 398 2 . . . cord-006856-b1w25ob5 399 1 The the DT cord-006856-b1w25ob5 399 2 findings finding NNS cord-006856-b1w25ob5 399 3 confirm confirm VBP cord-006856-b1w25ob5 399 4 previous previous JJ cord-006856-b1w25ob5 399 5 studies study NNS cord-006856-b1w25ob5 399 6 that that WDT cord-006856-b1w25ob5 399 7 NT NT NNP cord-006856-b1w25ob5 399 8 pro pro JJ cord-006856-b1w25ob5 399 9 - - JJ cord-006856-b1w25ob5 399 10 BNP bnp JJ cord-006856-b1w25ob5 399 11 levels level NNS cord-006856-b1w25ob5 399 12 are be VBP cord-006856-b1w25ob5 399 13 increased increase VBN cord-006856-b1w25ob5 399 14 in in IN cord-006856-b1w25ob5 399 15 asymptomatic asymptomatic JJ cord-006856-b1w25ob5 399 16 long long JJ cord-006856-b1w25ob5 399 17 - - HYPH cord-006856-b1w25ob5 399 18 term term NN cord-006856-b1w25ob5 399 19 HTx HTx NNS cord-006856-b1w25ob5 399 20 recipients recipient NNS cord-006856-b1w25ob5 399 21 . . . cord-006856-b1w25ob5 400 1 A a DT cord-006856-b1w25ob5 400 2 larger large JJR cord-006856-b1w25ob5 400 3 sample sample NN cord-006856-b1w25ob5 400 4 size size NN cord-006856-b1w25ob5 400 5 is be VBZ cord-006856-b1w25ob5 400 6 warranted warrant VBN cord-006856-b1w25ob5 400 7 , , , cord-006856-b1w25ob5 400 8 however however RB cord-006856-b1w25ob5 400 9 , , , cord-006856-b1w25ob5 400 10 to to TO cord-006856-b1w25ob5 400 11 support support VB cord-006856-b1w25ob5 400 12 the the DT cord-006856-b1w25ob5 400 13 hypothesis hypothesis NN cord-006856-b1w25ob5 400 14 that that WDT cord-006856-b1w25ob5 400 15 NT NT NNP cord-006856-b1w25ob5 400 16 pro pro JJ cord-006856-b1w25ob5 400 17 - - JJ cord-006856-b1w25ob5 400 18 BNP BNP NNP cord-006856-b1w25ob5 400 19 might may MD cord-006856-b1w25ob5 400 20 be be VB cord-006856-b1w25ob5 400 21 a a DT cord-006856-b1w25ob5 400 22 useful useful JJ cord-006856-b1w25ob5 400 23 indicator indicator NN cord-006856-b1w25ob5 400 24 to to TO cord-006856-b1w25ob5 400 25 predict predict VB cord-006856-b1w25ob5 400 26 physical physical JJ cord-006856-b1w25ob5 400 27 fitness fitness NN cord-006856-b1w25ob5 400 28 in in IN cord-006856-b1w25ob5 400 29 these these DT cord-006856-b1w25ob5 400 30 patients patient NNS cord-006856-b1w25ob5 400 31 . . . cord-006856-b1w25ob5 401 1 Calcineurin calcineurin JJ cord-006856-b1w25ob5 401 2 inhibitor inhibitor NN cord-006856-b1w25ob5 401 3 therapy therapy NN cord-006856-b1w25ob5 401 4 is be VBZ cord-006856-b1w25ob5 401 5 an an DT cord-006856-b1w25ob5 401 6 important important JJ cord-006856-b1w25ob5 401 7 cause cause NN cord-006856-b1w25ob5 401 8 of of IN cord-006856-b1w25ob5 401 9 renal renal JJ cord-006856-b1w25ob5 401 10 dysfunction dysfunction NN cord-006856-b1w25ob5 401 11 in in IN cord-006856-b1w25ob5 401 12 heart heart NN cord-006856-b1w25ob5 401 13 transplant transplant NN cord-006856-b1w25ob5 401 14 patients patient NNS cord-006856-b1w25ob5 401 15 . . . cord-006856-b1w25ob5 402 1 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 402 2 ( ( -LRB- cord-006856-b1w25ob5 402 3 Srl Srl NNP cord-006856-b1w25ob5 402 4 ) ) -RRB- cord-006856-b1w25ob5 402 5 is be VBZ cord-006856-b1w25ob5 402 6 a a DT cord-006856-b1w25ob5 402 7 novel novel JJ cord-006856-b1w25ob5 402 8 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 402 9 ( ( -LRB- cord-006856-b1w25ob5 402 10 IS is NN cord-006856-b1w25ob5 402 11 ) ) -RRB- cord-006856-b1w25ob5 402 12 drug drug NN cord-006856-b1w25ob5 402 13 without without IN cord-006856-b1w25ob5 402 14 nephrotoxic nephrotoxic NNP cord-006856-b1w25ob5 402 15 side side NN cord-006856-b1w25ob5 402 16 effects effect NNS cord-006856-b1w25ob5 402 17 . . . cord-006856-b1w25ob5 403 1 However however RB cord-006856-b1w25ob5 403 2 , , , cord-006856-b1w25ob5 403 3 cases case NNS cord-006856-b1w25ob5 403 4 of of IN cord-006856-b1w25ob5 403 5 proteinuria proteinuria NN cord-006856-b1w25ob5 403 6 associated associate VBN cord-006856-b1w25ob5 403 7 with with IN cord-006856-b1w25ob5 403 8 Srl Srl NNP cord-006856-b1w25ob5 403 9 have have VBP cord-006856-b1w25ob5 403 10 been be VBN cord-006856-b1w25ob5 403 11 reported report VBN cord-006856-b1w25ob5 403 12 following follow VBG cord-006856-b1w25ob5 403 13 renal renal JJ cord-006856-b1w25ob5 403 14 transplantation transplantation NN cord-006856-b1w25ob5 403 15 . . . cord-006856-b1w25ob5 404 1 In in IN cord-006856-b1w25ob5 404 2 cardiac cardiac JJ cord-006856-b1w25ob5 404 3 transplantation transplantation NN cord-006856-b1w25ob5 404 4 the the DT cord-006856-b1w25ob5 404 5 potential potential JJ cord-006856-b1w25ob5 404 6 incidence incidence NN cord-006856-b1w25ob5 404 7 of of IN cord-006856-b1w25ob5 404 8 proteinuria proteinuria NN cord-006856-b1w25ob5 404 9 is be VBZ cord-006856-b1w25ob5 404 10 not not RB cord-006856-b1w25ob5 404 11 known know VBN cord-006856-b1w25ob5 404 12 . . . cord-006856-b1w25ob5 405 1 29 29 CD cord-006856-b1w25ob5 405 2 long long JJ cord-006856-b1w25ob5 405 3 - - HYPH cord-006856-b1w25ob5 405 4 term term NN cord-006856-b1w25ob5 405 5 cardiac cardiac JJ cord-006856-b1w25ob5 405 6 transplant transplant NN cord-006856-b1w25ob5 405 7 patients patient NNS cord-006856-b1w25ob5 405 8 ( ( -LRB- cord-006856-b1w25ob5 405 9 age age NN cord-006856-b1w25ob5 405 10 , , , cord-006856-b1w25ob5 405 11 60.9 60.9 CD cord-006856-b1w25ob5 405 12 ± ± CD cord-006856-b1w25ob5 405 13 7.3 7.3 CD cord-006856-b1w25ob5 405 14 years year NNS cord-006856-b1w25ob5 405 15 ) ) -RRB- cord-006856-b1w25ob5 405 16 were be VBD cord-006856-b1w25ob5 405 17 switched switch VBN cord-006856-b1w25ob5 405 18 from from IN cord-006856-b1w25ob5 405 19 Cyclosporine cyclosporine NN cord-006856-b1w25ob5 405 20 - - HYPH cord-006856-b1w25ob5 405 21 based base VBN cord-006856-b1w25ob5 405 22 immunosuppression immunosuppression NN cord-006856-b1w25ob5 405 23 to to IN cord-006856-b1w25ob5 405 24 a a DT cord-006856-b1w25ob5 405 25 Srl Srl NNP cord-006856-b1w25ob5 405 26 - - HYPH cord-006856-b1w25ob5 405 27 based base VBN cord-006856-b1w25ob5 405 28 IS be VBZ cord-006856-b1w25ob5 405 29 8.8 8.8 CD cord-006856-b1w25ob5 405 30 ± ± NNP cord-006856-b1w25ob5 405 31 4.5 4.5 CD cord-006856-b1w25ob5 405 32 years year NNS cord-006856-b1w25ob5 405 33 after after IN cord-006856-b1w25ob5 405 34 transplantation transplantation NN cord-006856-b1w25ob5 405 35 . . . cord-006856-b1w25ob5 406 1 Concomitant concomitant JJ cord-006856-b1w25ob5 406 2 IS be VBZ cord-006856-b1w25ob5 406 3 consisted consist VBN cord-006856-b1w25ob5 406 4 of of IN cord-006856-b1w25ob5 406 5 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 406 6 - - HYPH cord-006856-b1w25ob5 406 7 Mofetil Mofetil NNP cord-006856-b1w25ob5 406 8 with with IN cord-006856-b1w25ob5 406 9 or or CC cord-006856-b1w25ob5 406 10 without without IN cord-006856-b1w25ob5 406 11 steroids steroid NNS cord-006856-b1w25ob5 406 12 . . . cord-006856-b1w25ob5 407 1 Two two CD cord-006856-b1w25ob5 407 2 patients patient NNS cord-006856-b1w25ob5 407 3 died die VBD cord-006856-b1w25ob5 407 4 14 14 CD cord-006856-b1w25ob5 407 5 and and CC cord-006856-b1w25ob5 407 6 37 37 CD cord-006856-b1w25ob5 407 7 months month NNS cord-006856-b1w25ob5 407 8 post post NN cord-006856-b1w25ob5 407 9 switch switch NN cord-006856-b1w25ob5 407 10 due due IN cord-006856-b1w25ob5 407 11 to to IN cord-006856-b1w25ob5 407 12 infection infection NN cord-006856-b1w25ob5 407 13 . . . cord-006856-b1w25ob5 408 1 Both both DT cord-006856-b1w25ob5 408 2 patients patient NNS cord-006856-b1w25ob5 408 3 were be VBD cord-006856-b1w25ob5 408 4 dialysis dialysis NN cord-006856-b1w25ob5 408 5 dependent dependent JJ cord-006856-b1w25ob5 408 6 at at IN cord-006856-b1w25ob5 408 7 time time NN cord-006856-b1w25ob5 408 8 of of IN cord-006856-b1w25ob5 408 9 death death NN cord-006856-b1w25ob5 408 10 . . . cord-006856-b1w25ob5 409 1 One one CD cord-006856-b1w25ob5 409 2 other other JJ cord-006856-b1w25ob5 409 3 patient patient NN cord-006856-b1w25ob5 409 4 was be VBD cord-006856-b1w25ob5 409 5 switched switch VBN cord-006856-b1w25ob5 409 6 back back RB cord-006856-b1w25ob5 409 7 to to IN cord-006856-b1w25ob5 409 8 CNI CNI NNP cord-006856-b1w25ob5 409 9 - - HYPH cord-006856-b1w25ob5 409 10 based base VBN cord-006856-b1w25ob5 409 11 IS be VBZ cord-006856-b1w25ob5 409 12 due due JJ cord-006856-b1w25ob5 409 13 to to IN cord-006856-b1w25ob5 409 14 interstitial interstitial JJ cord-006856-b1w25ob5 409 15 nephritis nephritis NN cord-006856-b1w25ob5 409 16 . . . cord-006856-b1w25ob5 410 1 24 24 CD cord-006856-b1w25ob5 410 2 h h NN cord-006856-b1w25ob5 410 3 collections collection NNS cord-006856-b1w25ob5 410 4 of of IN cord-006856-b1w25ob5 410 5 urine urine NN cord-006856-b1w25ob5 410 6 were be VBD cord-006856-b1w25ob5 410 7 performed perform VBN cord-006856-b1w25ob5 410 8 in in IN cord-006856-b1w25ob5 410 9 all all DT cord-006856-b1w25ob5 410 10 patients patient NNS cord-006856-b1w25ob5 410 11 before before IN cord-006856-b1w25ob5 410 12 switch switch NN cord-006856-b1w25ob5 410 13 and and CC cord-006856-b1w25ob5 410 14 at at IN cord-006856-b1w25ob5 410 15 several several JJ cord-006856-b1w25ob5 410 16 time time NN cord-006856-b1w25ob5 410 17 points point NNS cord-006856-b1w25ob5 410 18 post post NN cord-006856-b1w25ob5 410 19 switch switch NN cord-006856-b1w25ob5 410 20 to to TO cord-006856-b1w25ob5 410 21 measure measure VB cord-006856-b1w25ob5 410 22 proteinuria proteinuria NN cord-006856-b1w25ob5 410 23 . . . cord-006856-b1w25ob5 411 1 Proteinuria Proteinuria NNP cord-006856-b1w25ob5 411 2 increased increase VBD cord-006856-b1w25ob5 411 3 significantly significantly RB cord-006856-b1w25ob5 411 4 from from IN cord-006856-b1w25ob5 411 5 0.45 0.45 CD cord-006856-b1w25ob5 411 6 ± ± XX cord-006856-b1w25ob5 412 1 1.0 1.0 CD cord-006856-b1w25ob5 412 2 mg mg NNP cord-006856-b1w25ob5 412 3 / / SYM cord-006856-b1w25ob5 412 4 dl dl NNP cord-006856-b1w25ob5 412 5 ( ( -LRB- cord-006856-b1w25ob5 412 6 median median NN cord-006856-b1w25ob5 412 7 , , , cord-006856-b1w25ob5 412 8 0.17 0.17 CD cord-006856-b1w25ob5 412 9 ) ) -RRB- cord-006856-b1w25ob5 412 10 pre pre VBD cord-006856-b1w25ob5 412 11 switch switch VB cord-006856-b1w25ob5 412 12 to to IN cord-006856-b1w25ob5 412 13 1.03 1.03 CD cord-006856-b1w25ob5 412 14 ± ± CD cord-006856-b1w25ob5 412 15 2.04 2.04 CD cord-006856-b1w25ob5 413 1 mg mg NNP cord-006856-b1w25ob5 413 2 / / SYM cord-006856-b1w25ob5 413 3 dl dl NNP cord-006856-b1w25ob5 413 4 ( ( -LRB- cord-006856-b1w25ob5 413 5 median median NN cord-006856-b1w25ob5 413 6 , , , cord-006856-b1w25ob5 413 7 0.21 0.21 CD cord-006856-b1w25ob5 413 8 ) ) -RRB- cord-006856-b1w25ob5 413 9 post post NN cord-006856-b1w25ob5 413 10 switch switch NN cord-006856-b1w25ob5 413 11 ( ( -LRB- cord-006856-b1w25ob5 413 12 P p NN cord-006856-b1w25ob5 413 13 = = SYM cord-006856-b1w25ob5 413 14 0.017 0.017 CD cord-006856-b1w25ob5 413 15 ) ) -RRB- cord-006856-b1w25ob5 413 16 . . . cord-006856-b1w25ob5 414 1 Proteinuria Proteinuria NNP cord-006856-b1w25ob5 414 2 of of IN cord-006856-b1w25ob5 414 3 0.21 0.21 CD cord-006856-b1w25ob5 414 4 - - SYM cord-006856-b1w25ob5 414 5 1.0 1.0 CD cord-006856-b1w25ob5 414 6 mg mg NNP cord-006856-b1w25ob5 414 7 / / SYM cord-006856-b1w25ob5 414 8 dl dl NNP cord-006856-b1w25ob5 414 9 was be VBD cord-006856-b1w25ob5 414 10 seen see VBN cord-006856-b1w25ob5 414 11 in in IN cord-006856-b1w25ob5 414 12 21 21 CD cord-006856-b1w25ob5 414 13 % % NN cord-006856-b1w25ob5 414 14 of of IN cord-006856-b1w25ob5 414 15 patients patient NNS cord-006856-b1w25ob5 414 16 before before IN cord-006856-b1w25ob5 414 17 switch switch NN cord-006856-b1w25ob5 414 18 and and CC cord-006856-b1w25ob5 414 19 in in IN cord-006856-b1w25ob5 414 20 28 28 CD cord-006856-b1w25ob5 414 21 % % NN cord-006856-b1w25ob5 414 22 after after IN cord-006856-b1w25ob5 414 23 switch switch NN cord-006856-b1w25ob5 414 24 . . . cord-006856-b1w25ob5 415 1 Proteinuria Proteinuria NNP cord-006856-b1w25ob5 415 2 of of IN cord-006856-b1w25ob5 415 3 > > XX cord-006856-b1w25ob5 416 1 1.0 1.0 CD cord-006856-b1w25ob5 416 2 mg mg NNP cord-006856-b1w25ob5 416 3 / / SYM cord-006856-b1w25ob5 416 4 dl dl NNP cord-006856-b1w25ob5 416 5 was be VBD cord-006856-b1w25ob5 416 6 seen see VBN cord-006856-b1w25ob5 416 7 in in IN cord-006856-b1w25ob5 416 8 10 10 CD cord-006856-b1w25ob5 416 9 % % NN cord-006856-b1w25ob5 416 10 of of IN cord-006856-b1w25ob5 416 11 patients patient NNS cord-006856-b1w25ob5 416 12 before before IN cord-006856-b1w25ob5 416 13 switch switch NN cord-006856-b1w25ob5 416 14 and and CC cord-006856-b1w25ob5 416 15 in in IN cord-006856-b1w25ob5 416 16 24 24 CD cord-006856-b1w25ob5 416 17 % % NN cord-006856-b1w25ob5 416 18 after after IN cord-006856-b1w25ob5 416 19 switch switch NN cord-006856-b1w25ob5 416 20 ( ( -LRB- cord-006856-b1w25ob5 416 21 n.s n.s NNP cord-006856-b1w25ob5 416 22 . . NNP cord-006856-b1w25ob5 416 23 ) ) -RRB- cord-006856-b1w25ob5 416 24 . . . cord-006856-b1w25ob5 417 1 Three three CD cord-006856-b1w25ob5 417 2 patients patient NNS cord-006856-b1w25ob5 417 3 developed develop VBD cord-006856-b1w25ob5 417 4 severe severe JJ cord-006856-b1w25ob5 417 5 proteinuria proteinuria NN cord-006856-b1w25ob5 417 6 ( ( -LRB- cord-006856-b1w25ob5 417 7 > > NFP cord-006856-b1w25ob5 417 8 3.5 3.5 CD cord-006856-b1w25ob5 417 9 mg mg NNP cord-006856-b1w25ob5 417 10 / / SYM cord-006856-b1w25ob5 417 11 dl dl NNP cord-006856-b1w25ob5 417 12 ) ) -RRB- cord-006856-b1w25ob5 417 13 after after IN cord-006856-b1w25ob5 417 14 switch switch NN cord-006856-b1w25ob5 417 15 . . . cord-006856-b1w25ob5 418 1 One one CD cord-006856-b1w25ob5 418 2 died die VBD cord-006856-b1w25ob5 418 3 on on IN cord-006856-b1w25ob5 418 4 dialysis dialysis NN cord-006856-b1w25ob5 418 5 , , , cord-006856-b1w25ob5 418 6 one one CD cord-006856-b1w25ob5 418 7 was be VBD cord-006856-b1w25ob5 418 8 switched switch VBN cord-006856-b1w25ob5 418 9 back back RB cord-006856-b1w25ob5 418 10 to to IN cord-006856-b1w25ob5 418 11 CNI CNI NNP cord-006856-b1w25ob5 418 12 and and CC cord-006856-b1w25ob5 418 13 one one CD cord-006856-b1w25ob5 418 14 still still RB cord-006856-b1w25ob5 418 15 remains remain VBZ cord-006856-b1w25ob5 418 16 on on IN cord-006856-b1w25ob5 418 17 Srl Srl NNP cord-006856-b1w25ob5 418 18 . . . cord-006856-b1w25ob5 419 1 In in IN cord-006856-b1w25ob5 419 2 conclusion conclusion NN cord-006856-b1w25ob5 419 3 , , , cord-006856-b1w25ob5 419 4 proteinuria proteinuria NN cord-006856-b1w25ob5 419 5 may may MD cord-006856-b1w25ob5 419 6 develop develop VB cord-006856-b1w25ob5 419 7 in in IN cord-006856-b1w25ob5 419 8 cardiac cardiac JJ cord-006856-b1w25ob5 419 9 transplant transplant NN cord-006856-b1w25ob5 419 10 patients patient NNS cord-006856-b1w25ob5 419 11 after after IN cord-006856-b1w25ob5 419 12 switch switch NN cord-006856-b1w25ob5 419 13 to to IN cord-006856-b1w25ob5 419 14 Srl Srl NNP cord-006856-b1w25ob5 419 15 - - HYPH cord-006856-b1w25ob5 419 16 based base VBN cord-006856-b1w25ob5 419 17 IS be VBZ cord-006856-b1w25ob5 419 18 . . . cord-006856-b1w25ob5 420 1 Srl Srl NNP cord-006856-b1w25ob5 420 2 seems seem VBZ cord-006856-b1w25ob5 420 3 to to TO cord-006856-b1w25ob5 420 4 have have VB cord-006856-b1w25ob5 420 5 a a DT cord-006856-b1w25ob5 420 6 potential potential JJ cord-006856-b1w25ob5 420 7 adverse adverse JJ cord-006856-b1w25ob5 420 8 renal renal JJ cord-006856-b1w25ob5 420 9 effect effect NN cord-006856-b1w25ob5 420 10 in in IN cord-006856-b1w25ob5 420 11 these these DT cord-006856-b1w25ob5 420 12 patients patient NNS cord-006856-b1w25ob5 420 13 . . . cord-006856-b1w25ob5 421 1 Srl Srl NNP cord-006856-b1w25ob5 421 2 should should MD cord-006856-b1w25ob5 421 3 be be VB cord-006856-b1w25ob5 421 4 used use VBN cord-006856-b1w25ob5 421 5 cautiously cautiously RB cord-006856-b1w25ob5 421 6 with with IN cord-006856-b1w25ob5 421 7 close close JJ cord-006856-b1w25ob5 421 8 monitoring monitoring NN cord-006856-b1w25ob5 421 9 for for IN cord-006856-b1w25ob5 421 10 proteinuria proteinuria NN cord-006856-b1w25ob5 421 11 or or CC cord-006856-b1w25ob5 421 12 increased increase VBN cord-006856-b1w25ob5 421 13 renal renal JJ cord-006856-b1w25ob5 421 14 dysfunction dysfunction NN cord-006856-b1w25ob5 421 15 . . . cord-006856-b1w25ob5 422 1 V21 V21 NNP cord-006856-b1w25ob5 422 2 Early early JJ cord-006856-b1w25ob5 422 3 growth growth NN cord-006856-b1w25ob5 422 4 - - HYPH cord-006856-b1w25ob5 422 5 response response NN cord-006856-b1w25ob5 422 6 factor-1 factor-1 NNP cord-006856-b1w25ob5 422 7 is be VBZ cord-006856-b1w25ob5 422 8 involved involve VBN cord-006856-b1w25ob5 422 9 in in IN cord-006856-b1w25ob5 422 10 cellular cellular JJ cord-006856-b1w25ob5 422 11 injury injury NN cord-006856-b1w25ob5 422 12 of of IN cord-006856-b1w25ob5 422 13 transplanted transplanted JJ cord-006856-b1w25ob5 422 14 hearts heart NNS cord-006856-b1w25ob5 422 15 Background Background NNP cord-006856-b1w25ob5 422 16 . . . cord-006856-b1w25ob5 423 1 We -PRON- PRP cord-006856-b1w25ob5 423 2 have have VBP cord-006856-b1w25ob5 423 3 shown show VBN cord-006856-b1w25ob5 423 4 a a DT cord-006856-b1w25ob5 423 5 persistent persistent JJ cord-006856-b1w25ob5 423 6 mitochondrial mitochondrial NN cord-006856-b1w25ob5 423 7 pathology pathology NN cord-006856-b1w25ob5 423 8 in in IN cord-006856-b1w25ob5 423 9 patients patient NNS cord-006856-b1w25ob5 423 10 with with IN cord-006856-b1w25ob5 423 11 idiopathic idiopathic JJ cord-006856-b1w25ob5 423 12 dilative dilative JJ cord-006856-b1w25ob5 423 13 ( ( -LRB- cord-006856-b1w25ob5 423 14 DCM DCM NNP cord-006856-b1w25ob5 423 15 ) ) -RRB- cord-006856-b1w25ob5 423 16 but but CC cord-006856-b1w25ob5 423 17 not not RB cord-006856-b1w25ob5 423 18 ischemic ischemic JJ cord-006856-b1w25ob5 423 19 ( ( -LRB- cord-006856-b1w25ob5 423 20 ICM ICM NNP cord-006856-b1w25ob5 423 21 ) ) -RRB- cord-006856-b1w25ob5 423 22 cardiomyopathy cardiomyopathy NN cord-006856-b1w25ob5 423 23 following follow VBG cord-006856-b1w25ob5 423 24 cardiac cardiac JJ cord-006856-b1w25ob5 423 25 transplantation transplantation NN cord-006856-b1w25ob5 423 26 . . . cord-006856-b1w25ob5 424 1 Early early JJ cord-006856-b1w25ob5 424 2 growth growth NN cord-006856-b1w25ob5 424 3 response response NN cord-006856-b1w25ob5 424 4 factor factor NN cord-006856-b1w25ob5 424 5 ( ( -LRB- cord-006856-b1w25ob5 424 6 Egr)-1 egr)-1 NN cord-006856-b1w25ob5 424 7 that that WDT cord-006856-b1w25ob5 424 8 is be VBZ cord-006856-b1w25ob5 424 9 stimulated stimulate VBN cord-006856-b1w25ob5 424 10 by by IN cord-006856-b1w25ob5 424 11 cytokines cytokine NNS cord-006856-b1w25ob5 424 12 and and CC cord-006856-b1w25ob5 424 13 hypoxia hypoxia NN cord-006856-b1w25ob5 424 14 is be VBZ cord-006856-b1w25ob5 424 15 suggested suggest VBN cord-006856-b1w25ob5 424 16 to to TO cord-006856-b1w25ob5 424 17 induce induce VB cord-006856-b1w25ob5 424 18 inflammation inflammation NN cord-006856-b1w25ob5 424 19 and and CC cord-006856-b1w25ob5 424 20 tissue tissue NN cord-006856-b1w25ob5 424 21 injury injury NN cord-006856-b1w25ob5 424 22 . . . cord-006856-b1w25ob5 425 1 Whether whether IN cord-006856-b1w25ob5 425 2 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 425 3 mediates mediate VBZ cord-006856-b1w25ob5 425 4 the the DT cord-006856-b1w25ob5 425 5 persistent persistent JJ cord-006856-b1w25ob5 425 6 cellular cellular JJ cord-006856-b1w25ob5 425 7 pathology pathology NN cord-006856-b1w25ob5 425 8 in in IN cord-006856-b1w25ob5 425 9 hearts heart NNS cord-006856-b1w25ob5 425 10 transplanted transplant VBN cord-006856-b1w25ob5 425 11 to to IN cord-006856-b1w25ob5 425 12 DCM DCM NNP cord-006856-b1w25ob5 425 13 patients patient NNS cord-006856-b1w25ob5 425 14 is be VBZ cord-006856-b1w25ob5 425 15 unknown unknown JJ cord-006856-b1w25ob5 425 16 . . . cord-006856-b1w25ob5 426 1 Methods method NNS cord-006856-b1w25ob5 426 2 . . . cord-006856-b1w25ob5 427 1 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 427 2 and and CC cord-006856-b1w25ob5 427 3 hypoxia hypoxia NN cord-006856-b1w25ob5 427 4 - - HYPH cord-006856-b1w25ob5 427 5 inducible inducible JJ cord-006856-b1w25ob5 427 6 factor-1 factor-1 NNP cord-006856-b1w25ob5 427 7 ( ( -LRB- cord-006856-b1w25ob5 427 8 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 427 9 ) ) -RRB- cord-006856-b1w25ob5 427 10 gene gene NN cord-006856-b1w25ob5 427 11 expression expression NN cord-006856-b1w25ob5 427 12 was be VBD cord-006856-b1w25ob5 427 13 examined examine VBN cord-006856-b1w25ob5 427 14 in in IN cord-006856-b1w25ob5 427 15 left left JJ cord-006856-b1w25ob5 427 16 ventricular ventricular JJ cord-006856-b1w25ob5 427 17 biopsies biopsy NNS cord-006856-b1w25ob5 427 18 of of IN cord-006856-b1w25ob5 427 19 explanted explanted JJ cord-006856-b1w25ob5 427 20 failing fail VBG cord-006856-b1w25ob5 427 21 hearts heart NNS cord-006856-b1w25ob5 427 22 in in IN cord-006856-b1w25ob5 427 23 28 28 CD cord-006856-b1w25ob5 427 24 ICM ICM NNP cord-006856-b1w25ob5 427 25 and and CC cord-006856-b1w25ob5 427 26 42 42 CD cord-006856-b1w25ob5 427 27 DCM DCM NNP cord-006856-b1w25ob5 427 28 patients patient NNS cord-006856-b1w25ob5 427 29 , , , cord-006856-b1w25ob5 427 30 as as RB cord-006856-b1w25ob5 427 31 well well RB cord-006856-b1w25ob5 427 32 as as IN cord-006856-b1w25ob5 427 33 in in IN cord-006856-b1w25ob5 427 34 12 12 CD cord-006856-b1w25ob5 427 35 donor donor NN cord-006856-b1w25ob5 427 36 grafts graft NNS cord-006856-b1w25ob5 427 37 before before IN cord-006856-b1w25ob5 427 38 reperfusion reperfusion NN cord-006856-b1w25ob5 427 39 ( ( -LRB- cord-006856-b1w25ob5 427 40 control control NN cord-006856-b1w25ob5 427 41 ) ) -RRB- cord-006856-b1w25ob5 427 42 , , , cord-006856-b1w25ob5 427 43 at at IN cord-006856-b1w25ob5 427 44 10 10 CD cord-006856-b1w25ob5 427 45 , , , cord-006856-b1w25ob5 427 46 30 30 CD cord-006856-b1w25ob5 427 47 , , , cord-006856-b1w25ob5 427 48 60 60 CD cord-006856-b1w25ob5 427 49 minutes minute NNS cord-006856-b1w25ob5 427 50 after after IN cord-006856-b1w25ob5 427 51 reperfusion reperfusion NN cord-006856-b1w25ob5 427 52 , , , cord-006856-b1w25ob5 427 53 and and CC cord-006856-b1w25ob5 427 54 at at IN cord-006856-b1w25ob5 427 55 1 1 CD cord-006856-b1w25ob5 427 56 , , , cord-006856-b1w25ob5 427 57 2 2 CD cord-006856-b1w25ob5 427 58 , , , cord-006856-b1w25ob5 427 59 3 3 CD cord-006856-b1w25ob5 427 60 , , , cord-006856-b1w25ob5 427 61 4 4 CD cord-006856-b1w25ob5 427 62 , , , cord-006856-b1w25ob5 427 63 6 6 CD cord-006856-b1w25ob5 427 64 , , , cord-006856-b1w25ob5 427 65 12 12 CD cord-006856-b1w25ob5 427 66 posttransplant posttransplant NN cord-006856-b1w25ob5 427 67 weeks week NNS cord-006856-b1w25ob5 427 68 , , , cord-006856-b1w25ob5 427 69 using use VBG cord-006856-b1w25ob5 427 70 real real JJ cord-006856-b1w25ob5 427 71 - - HYPH cord-006856-b1w25ob5 427 72 time time NN cord-006856-b1w25ob5 427 73 RT RT NNP cord-006856-b1w25ob5 427 74 - - HYPH cord-006856-b1w25ob5 427 75 PCR PCR NNP cord-006856-b1w25ob5 427 76 . . . cord-006856-b1w25ob5 428 1 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 428 2 binding bind VBG cord-006856-b1w25ob5 428 3 activity activity NN cord-006856-b1w25ob5 428 4 was be VBD cord-006856-b1w25ob5 428 5 examined examine VBN cord-006856-b1w25ob5 428 6 using use VBG cord-006856-b1w25ob5 428 7 EMSA EMSA NNP cord-006856-b1w25ob5 428 8 . . . cord-006856-b1w25ob5 429 1 Results result NNS cord-006856-b1w25ob5 429 2 . . . cord-006856-b1w25ob5 430 1 Egr-1 egr-1 JJ cord-006856-b1w25ob5 430 2 myocardial myocardial JJ cord-006856-b1w25ob5 430 3 gene gene NN cord-006856-b1w25ob5 430 4 expression expression NN cord-006856-b1w25ob5 430 5 was be VBD cord-006856-b1w25ob5 430 6 upregulated upregulate VBN cord-006856-b1w25ob5 430 7 in in IN cord-006856-b1w25ob5 430 8 DCM DCM NNP cord-006856-b1w25ob5 430 9 and and CC cord-006856-b1w25ob5 430 10 ICM ICM NNP cord-006856-b1w25ob5 430 11 ( ( -LRB- cord-006856-b1w25ob5 430 12 P p NN cord-006856-b1w25ob5 430 13 < < XX cord-006856-b1w25ob5 430 14 0.01 0.01 CD cord-006856-b1w25ob5 430 15 ) ) -RRB- cord-006856-b1w25ob5 430 16 . . . cord-006856-b1w25ob5 431 1 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 432 1 mRNA mRNA NNP cord-006856-b1w25ob5 432 2 levels level NNS cord-006856-b1w25ob5 432 3 were be VBD cord-006856-b1w25ob5 432 4 unchanged unchanged JJ cord-006856-b1w25ob5 432 5 in in IN cord-006856-b1w25ob5 432 6 both both DT cord-006856-b1w25ob5 432 7 groups group NNS cord-006856-b1w25ob5 432 8 , , , cord-006856-b1w25ob5 432 9 whereas whereas IN cord-006856-b1w25ob5 432 10 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 432 11 binding bind VBG cord-006856-b1w25ob5 432 12 activity activity NN cord-006856-b1w25ob5 432 13 was be VBD cord-006856-b1w25ob5 432 14 increased increase VBN cord-006856-b1w25ob5 432 15 in in IN cord-006856-b1w25ob5 432 16 ICM ICM NNP cord-006856-b1w25ob5 432 17 only only RB cord-006856-b1w25ob5 432 18 ( ( -LRB- cord-006856-b1w25ob5 432 19 P p NN cord-006856-b1w25ob5 432 20 < < XX cord-006856-b1w25ob5 432 21 0.01 0.01 CD cord-006856-b1w25ob5 432 22 ) ) -RRB- cord-006856-b1w25ob5 432 23 vs. vs. FW cord-006856-b1w25ob5 432 24 controls control NNS cord-006856-b1w25ob5 432 25 . . . cord-006856-b1w25ob5 433 1 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 433 2 and and CC cord-006856-b1w25ob5 433 3 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 433 4 myocardial myocardial JJ cord-006856-b1w25ob5 433 5 expression expression NN cord-006856-b1w25ob5 433 6 increased increase VBD cord-006856-b1w25ob5 433 7 during during IN cord-006856-b1w25ob5 433 8 reperfusion reperfusion NN cord-006856-b1w25ob5 433 9 in in IN cord-006856-b1w25ob5 433 10 donor donor NN cord-006856-b1w25ob5 433 11 grafts graft NNS cord-006856-b1w25ob5 434 1 ( ( -LRB- cord-006856-b1w25ob5 434 2 P p NN cord-006856-b1w25ob5 434 3 < < XX cord-006856-b1w25ob5 434 4 0.01 0.01 CD cord-006856-b1w25ob5 434 5 ) ) -RRB- cord-006856-b1w25ob5 434 6 vs. vs. CC cord-006856-b1w25ob5 434 7 control control NN cord-006856-b1w25ob5 434 8 hearts heart NNS cord-006856-b1w25ob5 434 9 . . . cord-006856-b1w25ob5 435 1 In in IN cord-006856-b1w25ob5 435 2 ICM ICM NNP cord-006856-b1w25ob5 435 3 group group NN cord-006856-b1w25ob5 435 4 , , , cord-006856-b1w25ob5 435 5 graft graft NN cord-006856-b1w25ob5 435 6 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 435 7 and and CC cord-006856-b1w25ob5 435 8 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 435 9 expression expression NN cord-006856-b1w25ob5 435 10 returned return VBD cord-006856-b1w25ob5 435 11 to to IN cord-006856-b1w25ob5 435 12 and and CC cord-006856-b1w25ob5 435 13 remained remain VBD cord-006856-b1w25ob5 435 14 at at IN cord-006856-b1w25ob5 435 15 the the DT cord-006856-b1w25ob5 435 16 baseline baseline JJ cord-006856-b1w25ob5 435 17 level level NN cord-006856-b1w25ob5 435 18 of of IN cord-006856-b1w25ob5 435 19 control control NN cord-006856-b1w25ob5 435 20 hearts heart NNS cord-006856-b1w25ob5 435 21 one one CD cord-006856-b1w25ob5 435 22 week week NN cord-006856-b1w25ob5 435 23 after after IN cord-006856-b1w25ob5 435 24 transplantation transplantation NN cord-006856-b1w25ob5 435 25 . . . cord-006856-b1w25ob5 436 1 In in IN cord-006856-b1w25ob5 436 2 contrast contrast NN cord-006856-b1w25ob5 436 3 , , , cord-006856-b1w25ob5 436 4 in in IN cord-006856-b1w25ob5 436 5 DCM DCM NNP cord-006856-b1w25ob5 436 6 group group NN cord-006856-b1w25ob5 436 7 , , , cord-006856-b1w25ob5 436 8 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 436 9 levels level NNS cord-006856-b1w25ob5 436 10 remained remain VBD cord-006856-b1w25ob5 436 11 significantly significantly RB cord-006856-b1w25ob5 436 12 upregulated upregulate VBN cord-006856-b1w25ob5 436 13 during during IN cord-006856-b1w25ob5 436 14 the the DT cord-006856-b1w25ob5 436 15 follow follow NN cord-006856-b1w25ob5 436 16 - - HYPH cord-006856-b1w25ob5 436 17 up up NN cord-006856-b1w25ob5 436 18 period period NN cord-006856-b1w25ob5 436 19 in in IN cord-006856-b1w25ob5 436 20 transplanted transplanted JJ cord-006856-b1w25ob5 436 21 hearts heart NNS cord-006856-b1w25ob5 436 22 ( ( -LRB- cord-006856-b1w25ob5 436 23 P p NN cord-006856-b1w25ob5 436 24 < < XX cord-006856-b1w25ob5 436 25 0.01 0.01 CD cord-006856-b1w25ob5 436 26 ) ) -RRB- cord-006856-b1w25ob5 436 27 , , , cord-006856-b1w25ob5 436 28 although although IN cord-006856-b1w25ob5 436 29 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 436 30 expression expression NN cord-006856-b1w25ob5 436 31 returned return VBD cord-006856-b1w25ob5 436 32 to to IN cord-006856-b1w25ob5 436 33 the the DT cord-006856-b1w25ob5 436 34 control control NN cord-006856-b1w25ob5 436 35 baseline baseline JJ cord-006856-b1w25ob5 436 36 level level NN cord-006856-b1w25ob5 436 37 one one CD cord-006856-b1w25ob5 436 38 week week NN cord-006856-b1w25ob5 436 39 after after IN cord-006856-b1w25ob5 436 40 transplantation transplantation NN cord-006856-b1w25ob5 436 41 . . . cord-006856-b1w25ob5 437 1 Conclusions conclusion NNS cord-006856-b1w25ob5 437 2 . . . cord-006856-b1w25ob5 438 1 Chronic chronic JJ cord-006856-b1w25ob5 438 2 hypoxia hypoxia NN cord-006856-b1w25ob5 438 3 specifically specifically RB cord-006856-b1w25ob5 438 4 triggers trigger VBZ cord-006856-b1w25ob5 438 5 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 438 6 binding bind VBG cord-006856-b1w25ob5 438 7 activity activity NN cord-006856-b1w25ob5 438 8 in in IN cord-006856-b1w25ob5 438 9 ICM ICM NNP cord-006856-b1w25ob5 438 10 , , , cord-006856-b1w25ob5 438 11 and and CC cord-006856-b1w25ob5 438 12 reperfusion reperfusion NN cord-006856-b1w25ob5 438 13 upregulates upregulate VBZ cord-006856-b1w25ob5 438 14 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 438 15 and and CC cord-006856-b1w25ob5 438 16 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 438 17 mRNA mRNA NNP cord-006856-b1w25ob5 438 18 expression expression NN cord-006856-b1w25ob5 438 19 in in IN cord-006856-b1w25ob5 438 20 heart heart NN cord-006856-b1w25ob5 438 21 grafts graft NNS cord-006856-b1w25ob5 438 22 . . . cord-006856-b1w25ob5 439 1 The the DT cord-006856-b1w25ob5 439 2 persisting persist VBG cord-006856-b1w25ob5 439 3 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 439 4 overexpression overexpression NN cord-006856-b1w25ob5 439 5 in in IN cord-006856-b1w25ob5 439 6 grafts graft NNS cord-006856-b1w25ob5 439 7 transplanted transplant VBN cord-006856-b1w25ob5 439 8 to to IN cord-006856-b1w25ob5 439 9 DCM DCM NNP cord-006856-b1w25ob5 439 10 patients patient NNS cord-006856-b1w25ob5 439 11 could could MD cord-006856-b1w25ob5 439 12 mediate mediate VB cord-006856-b1w25ob5 439 13 mitochondrial mitochondrial JJ cord-006856-b1w25ob5 439 14 impairment impairment NN cord-006856-b1w25ob5 439 15 . . . cord-006856-b1w25ob5 440 1 Targeting target VBG cord-006856-b1w25ob5 440 2 Egr-1 Egr-1 NNP cord-006856-b1w25ob5 440 3 overexpression overexpression NN cord-006856-b1w25ob5 440 4 that that WDT cord-006856-b1w25ob5 440 5 bypasses bypass VBZ cord-006856-b1w25ob5 440 6 HIF-1 HIF-1 NNP cord-006856-b1w25ob5 440 7 might may MD cord-006856-b1w25ob5 440 8 be be VB cord-006856-b1w25ob5 440 9 beneficial beneficial JJ cord-006856-b1w25ob5 440 10 to to TO cord-006856-b1w25ob5 440 11 counteract counteract VB cord-006856-b1w25ob5 440 12 acute acute JJ cord-006856-b1w25ob5 440 13 reperfusion reperfusion NN cord-006856-b1w25ob5 440 14 - - HYPH cord-006856-b1w25ob5 440 15 induced induce VBN cord-006856-b1w25ob5 440 16 injury injury NN cord-006856-b1w25ob5 440 17 , , , cord-006856-b1w25ob5 440 18 and and CC cord-006856-b1w25ob5 440 19 the the DT cord-006856-b1w25ob5 440 20 chronic chronic JJ cord-006856-b1w25ob5 440 21 cellular cellular JJ cord-006856-b1w25ob5 440 22 pathology pathology NN cord-006856-b1w25ob5 440 23 in in IN cord-006856-b1w25ob5 440 24 cardiac cardiac JJ cord-006856-b1w25ob5 440 25 grafts graft NNS cord-006856-b1w25ob5 440 26 transplanted transplant VBN cord-006856-b1w25ob5 440 27 to to IN cord-006856-b1w25ob5 440 28 DCM DCM NNP cord-006856-b1w25ob5 440 29 patients patient NNS cord-006856-b1w25ob5 440 30 . . . cord-006856-b1w25ob5 441 1 Introduction introduction NN cord-006856-b1w25ob5 441 2 . . . cord-006856-b1w25ob5 442 1 Giant giant JJ cord-006856-b1w25ob5 442 2 - - HYPH cord-006856-b1w25ob5 442 3 cell cell NN cord-006856-b1w25ob5 442 4 myocarditits myocarditit NNS cord-006856-b1w25ob5 442 5 ( ( -LRB- cord-006856-b1w25ob5 442 6 GCM GCM NNP cord-006856-b1w25ob5 442 7 ) ) -RRB- cord-006856-b1w25ob5 442 8 is be VBZ cord-006856-b1w25ob5 442 9 a a DT cord-006856-b1w25ob5 442 10 rare rare JJ cord-006856-b1w25ob5 442 11 and and CC cord-006856-b1w25ob5 442 12 frequently frequently RB cord-006856-b1w25ob5 442 13 fatal fatal JJ cord-006856-b1w25ob5 442 14 disorder disorder NN cord-006856-b1w25ob5 442 15 of of IN cord-006856-b1w25ob5 442 16 unknown unknown JJ cord-006856-b1w25ob5 442 17 origin origin NN cord-006856-b1w25ob5 442 18 that that WDT cord-006856-b1w25ob5 442 19 is be VBZ cord-006856-b1w25ob5 442 20 defined define VBN cord-006856-b1w25ob5 442 21 histopathologically histopathologically RB cord-006856-b1w25ob5 442 22 as as IN cord-006856-b1w25ob5 442 23 diffuse diffuse JJ cord-006856-b1w25ob5 442 24 myocardial myocardial JJ cord-006856-b1w25ob5 442 25 necrosis necrosis NN cord-006856-b1w25ob5 442 26 with with IN cord-006856-b1w25ob5 442 27 multinucleated multinucleated JJ cord-006856-b1w25ob5 442 28 giant giant JJ cord-006856-b1w25ob5 442 29 cells cell NNS cord-006856-b1w25ob5 442 30 in in IN cord-006856-b1w25ob5 442 31 the the DT cord-006856-b1w25ob5 442 32 absence absence NN cord-006856-b1w25ob5 442 33 of of IN cord-006856-b1w25ob5 442 34 sarcoid sarcoid JJ cord-006856-b1w25ob5 442 35 - - HYPH cord-006856-b1w25ob5 442 36 like like JJ cord-006856-b1w25ob5 442 37 granuloma granuloma NN cord-006856-b1w25ob5 442 38 . . . cord-006856-b1w25ob5 443 1 Patients patient NNS cord-006856-b1w25ob5 443 2 usually usually RB cord-006856-b1w25ob5 443 3 have have VBP cord-006856-b1w25ob5 443 4 ventricular ventricular JJ cord-006856-b1w25ob5 443 5 arrhythmias arrhythmia NNS cord-006856-b1w25ob5 443 6 or or CC cord-006856-b1w25ob5 443 7 congestive congestive JJ cord-006856-b1w25ob5 443 8 heart heart NN cord-006856-b1w25ob5 443 9 failure failure NN cord-006856-b1w25ob5 443 10 . . . cord-006856-b1w25ob5 444 1 Although although IN cord-006856-b1w25ob5 444 2 a a DT cord-006856-b1w25ob5 444 3 variety variety NN cord-006856-b1w25ob5 444 4 of of IN cord-006856-b1w25ob5 444 5 systemic systemic JJ cord-006856-b1w25ob5 444 6 disorders disorder NNS cord-006856-b1w25ob5 444 7 have have VBP cord-006856-b1w25ob5 444 8 been be VBN cord-006856-b1w25ob5 444 9 seen see VBN cord-006856-b1w25ob5 444 10 in in IN cord-006856-b1w25ob5 444 11 association association NN cord-006856-b1w25ob5 444 12 with with IN cord-006856-b1w25ob5 444 13 giant giant JJ cord-006856-b1w25ob5 444 14 cell cell NN cord-006856-b1w25ob5 444 15 mycocarditis mycocarditis NN cord-006856-b1w25ob5 444 16 , , , cord-006856-b1w25ob5 444 17 most most JJS cord-006856-b1w25ob5 444 18 cases case NNS cord-006856-b1w25ob5 444 19 occur occur VBP cord-006856-b1w25ob5 444 20 in in IN cord-006856-b1w25ob5 444 21 previously previously RB cord-006856-b1w25ob5 444 22 healthy healthy JJ cord-006856-b1w25ob5 444 23 adults adult NNS cord-006856-b1w25ob5 444 24 . . . cord-006856-b1w25ob5 445 1 Conclusive conclusive JJ cord-006856-b1w25ob5 445 2 diagnosis diagnosis NN cord-006856-b1w25ob5 445 3 requires require VBZ cord-006856-b1w25ob5 445 4 histologic histologic JJ cord-006856-b1w25ob5 445 5 analysis analysis NN cord-006856-b1w25ob5 445 6 of of IN cord-006856-b1w25ob5 445 7 myocardial myocardial JJ cord-006856-b1w25ob5 445 8 tissue tissue NN cord-006856-b1w25ob5 445 9 obtained obtain VBN cord-006856-b1w25ob5 445 10 by by IN cord-006856-b1w25ob5 445 11 endomyocardial endomyocardial JJ cord-006856-b1w25ob5 445 12 biopsy biopsy NNP cord-006856-b1w25ob5 445 13 ( ( -LRB- cord-006856-b1w25ob5 445 14 EMB EMB NNP cord-006856-b1w25ob5 445 15 ) ) -RRB- cord-006856-b1w25ob5 445 16 . . . cord-006856-b1w25ob5 446 1 Congestive congestive JJ cord-006856-b1w25ob5 446 2 heart heart NN cord-006856-b1w25ob5 446 3 failure failure NN cord-006856-b1w25ob5 446 4 ( ( -LRB- cord-006856-b1w25ob5 446 5 CHF CHF NNP cord-006856-b1w25ob5 446 6 ) ) -RRB- cord-006856-b1w25ob5 446 7 is be VBZ cord-006856-b1w25ob5 446 8 the the DT cord-006856-b1w25ob5 446 9 most most RBS cord-006856-b1w25ob5 446 10 common common JJ cord-006856-b1w25ob5 446 11 cardiac cardiac JJ cord-006856-b1w25ob5 446 12 presentation presentation NN cord-006856-b1w25ob5 446 13 ( ( -LRB- cord-006856-b1w25ob5 446 14 75 75 CD cord-006856-b1w25ob5 446 15 % % NN cord-006856-b1w25ob5 446 16 ) ) -RRB- cord-006856-b1w25ob5 446 17 , , , cord-006856-b1w25ob5 446 18 with with IN cord-006856-b1w25ob5 446 19 sustained sustain VBN cord-006856-b1w25ob5 446 20 , , , cord-006856-b1w25ob5 446 21 refractory refractory JJ cord-006856-b1w25ob5 446 22 ventricular ventricular JJ cord-006856-b1w25ob5 446 23 tachycardia tachycardia NN cord-006856-b1w25ob5 446 24 . . . cord-006856-b1w25ob5 447 1 The the DT cord-006856-b1w25ob5 447 2 case case NN cord-006856-b1w25ob5 447 3 presented present VBN cord-006856-b1w25ob5 447 4 here here RB cord-006856-b1w25ob5 447 5 is be VBZ cord-006856-b1w25ob5 447 6 that that DT cord-006856-b1w25ob5 447 7 of of IN cord-006856-b1w25ob5 447 8 a a DT cord-006856-b1w25ob5 447 9 65-old 65-old CD cord-006856-b1w25ob5 447 10 - - HYPH cord-006856-b1w25ob5 447 11 man man NN cord-006856-b1w25ob5 447 12 suffering suffering NN cord-006856-b1w25ob5 447 13 of of IN cord-006856-b1w25ob5 447 14 GCM GCM NNP cord-006856-b1w25ob5 447 15 in in IN cord-006856-b1w25ob5 447 16 whom whom WP cord-006856-b1w25ob5 447 17 an an DT cord-006856-b1w25ob5 447 18 extracorporeal extracorporeal JJ cord-006856-b1w25ob5 447 19 membrane membrane NN cord-006856-b1w25ob5 447 20 oxygenation oxygenation NN cord-006856-b1w25ob5 447 21 ( ( -LRB- cord-006856-b1w25ob5 447 22 ECMO ECMO NNP cord-006856-b1w25ob5 447 23 ) ) -RRB- cord-006856-b1w25ob5 447 24 had have VBD cord-006856-b1w25ob5 447 25 to to TO cord-006856-b1w25ob5 447 26 be be VB cord-006856-b1w25ob5 447 27 implanted implant VBN cord-006856-b1w25ob5 447 28 to to TO cord-006856-b1w25ob5 447 29 overcome overcome VB cord-006856-b1w25ob5 447 30 cardiogenic cardiogenic JJ cord-006856-b1w25ob5 447 31 shock shock NN cord-006856-b1w25ob5 447 32 . . . cord-006856-b1w25ob5 448 1 Antithymocyte Antithymocyte NNP cord-006856-b1w25ob5 448 2 gobuline gobuline NN cord-006856-b1w25ob5 448 3 ( ( -LRB- cord-006856-b1w25ob5 448 4 rATG ratg JJ cord-006856-b1w25ob5 448 5 , , , cord-006856-b1w25ob5 448 6 Thymoglobuline Thymoglobuline NNP cord-006856-b1w25ob5 448 7 , , , cord-006856-b1w25ob5 448 8 Sangstat Sangstat NNP cord-006856-b1w25ob5 448 9 ) ) -RRB- cord-006856-b1w25ob5 448 10 , , , cord-006856-b1w25ob5 448 11 respectively respectively RB cord-006856-b1w25ob5 448 12 ciclosporine ciclosporine NNP cord-006856-b1w25ob5 448 13 ( ( -LRB- cord-006856-b1w25ob5 448 14 INN INN NNP cord-006856-b1w25ob5 448 15 : : : cord-006856-b1w25ob5 448 16 cyclosporine cyclosporine NN cord-006856-b1w25ob5 448 17 ) ) -RRB- cord-006856-b1w25ob5 448 18 , , , cord-006856-b1w25ob5 448 19 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 448 20 and and CC cord-006856-b1w25ob5 448 21 steroids steroid NNS cord-006856-b1w25ob5 448 22 were be VBD cord-006856-b1w25ob5 448 23 utilized utilize VBN cord-006856-b1w25ob5 448 24 to to TO cord-006856-b1w25ob5 448 25 bridge bridge VB cord-006856-b1w25ob5 448 26 the the DT cord-006856-b1w25ob5 448 27 time time NN cord-006856-b1w25ob5 448 28 to to TO cord-006856-b1w25ob5 448 29 complete complete VB cord-006856-b1w25ob5 448 30 myocardial myocardial JJ cord-006856-b1w25ob5 448 31 recovery recovery NN cord-006856-b1w25ob5 448 32 . . . cord-006856-b1w25ob5 449 1 We -PRON- PRP cord-006856-b1w25ob5 449 2 are be VBP cord-006856-b1w25ob5 449 3 reporting report VBG cord-006856-b1w25ob5 449 4 the the DT cord-006856-b1w25ob5 449 5 first first JJ cord-006856-b1w25ob5 449 6 successful successful JJ cord-006856-b1w25ob5 449 7 implantation implantation NN cord-006856-b1w25ob5 449 8 and and CC cord-006856-b1w25ob5 449 9 bridging bridge VBG cord-006856-b1w25ob5 449 10 to to IN cord-006856-b1w25ob5 449 11 myocardial myocardial JJ cord-006856-b1w25ob5 449 12 regeneration regeneration NN cord-006856-b1w25ob5 449 13 in in IN cord-006856-b1w25ob5 449 14 a a DT cord-006856-b1w25ob5 449 15 patient patient NN cord-006856-b1w25ob5 449 16 suffering suffering NN cord-006856-b1w25ob5 449 17 of of IN cord-006856-b1w25ob5 449 18 GCM GCM NNP cord-006856-b1w25ob5 449 19 by by IN cord-006856-b1w25ob5 449 20 means mean NNS cord-006856-b1w25ob5 449 21 of of IN cord-006856-b1w25ob5 449 22 ECMO ecmo NN cord-006856-b1w25ob5 449 23 and and CC cord-006856-b1w25ob5 449 24 initiation initiation NN cord-006856-b1w25ob5 449 25 of of IN cord-006856-b1w25ob5 449 26 immunomodulating immunomodulate VBG cord-006856-b1w25ob5 449 27 drugs drug NNS cord-006856-b1w25ob5 449 28 including include VBG cord-006856-b1w25ob5 449 29 polyclonal polyclonal JJ cord-006856-b1w25ob5 449 30 rATG ratg NN cord-006856-b1w25ob5 449 31 . . . cord-006856-b1w25ob5 450 1 Clinical clinical JJ cord-006856-b1w25ob5 450 2 summary summary NN cord-006856-b1w25ob5 450 3 . . . cord-006856-b1w25ob5 451 1 A a DT cord-006856-b1w25ob5 451 2 65-year 65-year JJ cord-006856-b1w25ob5 451 3 - - HYPH cord-006856-b1w25ob5 451 4 old old JJ cord-006856-b1w25ob5 451 5 man man NN cord-006856-b1w25ob5 451 6 was be VBD cord-006856-b1w25ob5 451 7 admitted admit VBN cord-006856-b1w25ob5 451 8 to to IN cord-006856-b1w25ob5 451 9 a a DT cord-006856-b1w25ob5 451 10 public public JJ cord-006856-b1w25ob5 451 11 hospital hospital NN cord-006856-b1w25ob5 451 12 because because IN cord-006856-b1w25ob5 451 13 of of IN cord-006856-b1w25ob5 451 14 thoracic thoracic JJ cord-006856-b1w25ob5 451 15 pain pain NN cord-006856-b1w25ob5 451 16 , , , cord-006856-b1w25ob5 451 17 positive positive JJ cord-006856-b1w25ob5 451 18 heart heart NN cord-006856-b1w25ob5 451 19 enzymes enzyme NNS cord-006856-b1w25ob5 451 20 , , , cord-006856-b1w25ob5 451 21 and and CC cord-006856-b1w25ob5 451 22 a a DT cord-006856-b1w25ob5 451 23 highly highly RB cord-006856-b1w25ob5 451 24 pathologic pathologic JJ cord-006856-b1w25ob5 451 25 electrocardiogramm electrocardiogramm NN cord-006856-b1w25ob5 451 26 . . . cord-006856-b1w25ob5 452 1 Echocardiography echocardiography NN cord-006856-b1w25ob5 452 2 demonstrated demonstrate VBD cord-006856-b1w25ob5 452 3 a a DT cord-006856-b1w25ob5 452 4 pericardial pericardial JJ cord-006856-b1w25ob5 452 5 effusion effusion NN cord-006856-b1w25ob5 452 6 and and CC cord-006856-b1w25ob5 452 7 reduced reduce VBN cord-006856-b1w25ob5 452 8 left leave VBN cord-006856-b1w25ob5 452 9 ventricular ventricular JJ cord-006856-b1w25ob5 452 10 function function NN cord-006856-b1w25ob5 452 11 ( ( -LRB- cord-006856-b1w25ob5 452 12 LVF LVF NNP cord-006856-b1w25ob5 452 13 , , , cord-006856-b1w25ob5 452 14 EF EF NNP cord-006856-b1w25ob5 452 15 15 15 CD cord-006856-b1w25ob5 452 16 % % NN cord-006856-b1w25ob5 452 17 ) ) -RRB- cord-006856-b1w25ob5 452 18 . . . cord-006856-b1w25ob5 453 1 Performed perform VBN cord-006856-b1w25ob5 453 2 angiography angiography NN cord-006856-b1w25ob5 453 3 evidenced evidence VBD cord-006856-b1w25ob5 453 4 and and CC cord-006856-b1w25ob5 453 5 a a DT cord-006856-b1w25ob5 453 6 high high JJ cord-006856-b1w25ob5 453 7 - - HYPH cord-006856-b1w25ob5 453 8 grade grade NN cord-006856-b1w25ob5 453 9 stenosis stenosis NN cord-006856-b1w25ob5 453 10 of of IN cord-006856-b1w25ob5 453 11 the the DT cord-006856-b1w25ob5 453 12 Left left JJ cord-006856-b1w25ob5 453 13 anterior anterior JJ cord-006856-b1w25ob5 453 14 descending descend VBG cord-006856-b1w25ob5 453 15 ( ( -LRB- cord-006856-b1w25ob5 453 16 LAD lad NN cord-006856-b1w25ob5 453 17 ) ) -RRB- cord-006856-b1w25ob5 453 18 which which WDT cord-006856-b1w25ob5 453 19 led lead VBD cord-006856-b1w25ob5 453 20 to to IN cord-006856-b1w25ob5 453 21 stent stent NN cord-006856-b1w25ob5 453 22 implantation implantation NN cord-006856-b1w25ob5 453 23 . . . cord-006856-b1w25ob5 454 1 Despite despite IN cord-006856-b1w25ob5 454 2 stent stent NN cord-006856-b1w25ob5 454 3 placement placement NN cord-006856-b1w25ob5 454 4 , , , cord-006856-b1w25ob5 454 5 the the DT cord-006856-b1w25ob5 454 6 clinical clinical JJ cord-006856-b1w25ob5 454 7 condition condition NN cord-006856-b1w25ob5 454 8 worsened worsen VBD cord-006856-b1w25ob5 454 9 leading lead VBG cord-006856-b1w25ob5 454 10 to to IN cord-006856-b1w25ob5 454 11 cardiogenic cardiogenic JJ cord-006856-b1w25ob5 454 12 shock shock NN cord-006856-b1w25ob5 454 13 including include VBG cord-006856-b1w25ob5 454 14 incipient incipient JJ cord-006856-b1w25ob5 454 15 shock shock NN cord-006856-b1w25ob5 454 16 liver liver NN cord-006856-b1w25ob5 454 17 . . . cord-006856-b1w25ob5 455 1 In in IN cord-006856-b1w25ob5 455 2 this this DT cord-006856-b1w25ob5 455 3 clinical clinical JJ cord-006856-b1w25ob5 455 4 condition condition NN cord-006856-b1w25ob5 455 5 the the DT cord-006856-b1w25ob5 455 6 patient patient NN cord-006856-b1w25ob5 455 7 was be VBD cord-006856-b1w25ob5 455 8 transferred transfer VBN cord-006856-b1w25ob5 455 9 to to IN cord-006856-b1w25ob5 455 10 our -PRON- PRP$ cord-006856-b1w25ob5 455 11 institution institution NN cord-006856-b1w25ob5 455 12 . . . cord-006856-b1w25ob5 456 1 In in IN cord-006856-b1w25ob5 456 2 addition addition NN cord-006856-b1w25ob5 456 3 , , , cord-006856-b1w25ob5 456 4 the the DT cord-006856-b1w25ob5 456 5 patient patient NN cord-006856-b1w25ob5 456 6 developed develop VBD cord-006856-b1w25ob5 456 7 malign malign JJ cord-006856-b1w25ob5 456 8 ventricular ventricular JJ cord-006856-b1w25ob5 456 9 tachycardia tachycardia NN cord-006856-b1w25ob5 456 10 ( ( -LRB- cord-006856-b1w25ob5 456 11 Lowen Lowen NNP cord-006856-b1w25ob5 456 12 IV IV NNP cord-006856-b1w25ob5 456 13 ) ) -RRB- cord-006856-b1w25ob5 456 14 and and CC cord-006856-b1w25ob5 456 15 had have VBD cord-006856-b1w25ob5 456 16 to to TO cord-006856-b1w25ob5 456 17 undergo undergo VB cord-006856-b1w25ob5 456 18 repetitive repetitive JJ cord-006856-b1w25ob5 456 19 defibrillation defibrillation NN cord-006856-b1w25ob5 456 20 . . . cord-006856-b1w25ob5 457 1 In in IN cord-006856-b1w25ob5 457 2 this this DT cord-006856-b1w25ob5 457 3 clinical clinical JJ cord-006856-b1w25ob5 457 4 scenario scenario NN cord-006856-b1w25ob5 457 5 it -PRON- PRP cord-006856-b1w25ob5 457 6 was be VBD cord-006856-b1w25ob5 457 7 decided decide VBN cord-006856-b1w25ob5 457 8 to to TO cord-006856-b1w25ob5 457 9 implant implant VB cord-006856-b1w25ob5 457 10 a a DT cord-006856-b1w25ob5 457 11 femoral femoral JJ cord-006856-b1w25ob5 457 12 veno veno NN cord-006856-b1w25ob5 457 13 - - HYPH cord-006856-b1w25ob5 457 14 arterial arterial JJ cord-006856-b1w25ob5 457 15 ECMO ECMO NNP cord-006856-b1w25ob5 457 16 . . . cord-006856-b1w25ob5 458 1 The the DT cord-006856-b1w25ob5 458 2 patient patient NN cord-006856-b1w25ob5 458 3 's 's POS cord-006856-b1w25ob5 458 4 metabolic metabolic JJ cord-006856-b1w25ob5 458 5 data datum NNS cord-006856-b1w25ob5 458 6 improved improve VBD cord-006856-b1w25ob5 458 7 noticeably noticeably RB cord-006856-b1w25ob5 458 8 ; ; : cord-006856-b1w25ob5 458 9 however however RB cord-006856-b1w25ob5 458 10 , , , cord-006856-b1w25ob5 458 11 due due IN cord-006856-b1w25ob5 458 12 to to IN cord-006856-b1w25ob5 458 13 repeated repeat VBN cord-006856-b1w25ob5 458 14 ventricular ventricular JJ cord-006856-b1w25ob5 458 15 tachycardia tachycardia NN cord-006856-b1w25ob5 458 16 , , , cord-006856-b1w25ob5 458 17 the the DT cord-006856-b1w25ob5 458 18 patient patient NN cord-006856-b1w25ob5 458 19 had have VBD cord-006856-b1w25ob5 458 20 to to TO cord-006856-b1w25ob5 458 21 be be VB cord-006856-b1w25ob5 458 22 defibrillated defibrillate VBN cord-006856-b1w25ob5 458 23 multiple multiple JJ cord-006856-b1w25ob5 458 24 times time NNS cord-006856-b1w25ob5 458 25 ( ( -LRB- cord-006856-b1w25ob5 458 26 max max NNP cord-006856-b1w25ob5 458 27 . . NNP cord-006856-b1w25ob5 458 28 30×/d 30×/d CD cord-006856-b1w25ob5 458 29 ) ) -RRB- cord-006856-b1w25ob5 458 30 . . . cord-006856-b1w25ob5 459 1 To to TO cord-006856-b1w25ob5 459 2 define define VB cord-006856-b1w25ob5 459 3 exact exact JJ cord-006856-b1w25ob5 459 4 cardiac cardiac JJ cord-006856-b1w25ob5 459 5 pathology pathology NN cord-006856-b1w25ob5 459 6 , , , cord-006856-b1w25ob5 459 7 we -PRON- PRP cord-006856-b1w25ob5 459 8 performed perform VBD cord-006856-b1w25ob5 459 9 a a DT cord-006856-b1w25ob5 459 10 heart heart NN cord-006856-b1w25ob5 459 11 biopsy biopsy JJ cord-006856-b1w25ob5 459 12 with with IN cord-006856-b1w25ob5 459 13 the the DT cord-006856-b1w25ob5 459 14 pathology pathology NN cord-006856-b1w25ob5 459 15 of of IN cord-006856-b1w25ob5 459 16 GCM GCM NNP cord-006856-b1w25ob5 459 17 . . . cord-006856-b1w25ob5 460 1 Immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 460 2 therapy therapy NN cord-006856-b1w25ob5 460 3 with with IN cord-006856-b1w25ob5 460 4 cyclosporine cyclosporine NN cord-006856-b1w25ob5 460 5 ( ( -LRB- cord-006856-b1w25ob5 460 6 50 50 CD cord-006856-b1w25ob5 460 7 mg mg NNP cord-006856-b1w25ob5 460 8 / / SYM cord-006856-b1w25ob5 460 9 d d NN cord-006856-b1w25ob5 460 10 ) ) -RRB- cord-006856-b1w25ob5 460 11 , , , cord-006856-b1w25ob5 460 12 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 460 13 and and CC cord-006856-b1w25ob5 460 14 Prednisolon Prednisolon NNP cord-006856-b1w25ob5 460 15 ( ( -LRB- cord-006856-b1w25ob5 460 16 250 250 CD cord-006856-b1w25ob5 460 17 mg mg NNP cord-006856-b1w25ob5 460 18 / / SYM cord-006856-b1w25ob5 460 19 d d NN cord-006856-b1w25ob5 460 20 ) ) -RRB- cord-006856-b1w25ob5 460 21 was be VBD cord-006856-b1w25ob5 460 22 initiated initiate VBN cord-006856-b1w25ob5 460 23 . . . cord-006856-b1w25ob5 461 1 In in IN cord-006856-b1w25ob5 461 2 addition addition NN cord-006856-b1w25ob5 461 3 , , , cord-006856-b1w25ob5 461 4 rabbit rabbit NN cord-006856-b1w25ob5 461 5 ATG ATG NNP cord-006856-b1w25ob5 461 6 ( ( -LRB- cord-006856-b1w25ob5 461 7 rATG ratg JJ cord-006856-b1w25ob5 461 8 , , , cord-006856-b1w25ob5 461 9 Thymoglobuline Thymoglobuline NNP cord-006856-b1w25ob5 461 10 , , , cord-006856-b1w25ob5 461 11 Sangstat Sangstat NNP cord-006856-b1w25ob5 461 12 ) ) -RRB- cord-006856-b1w25ob5 461 13 at at IN cord-006856-b1w25ob5 461 14 the the DT cord-006856-b1w25ob5 461 15 dosage dosage NN cord-006856-b1w25ob5 461 16 of of IN cord-006856-b1w25ob5 461 17 75 75 CD cord-006856-b1w25ob5 461 18 mg mg NNP cord-006856-b1w25ob5 461 19 / / SYM cord-006856-b1w25ob5 461 20 d d NNP cord-006856-b1w25ob5 461 21 was be VBD cord-006856-b1w25ob5 461 22 added add VBN cord-006856-b1w25ob5 461 23 to to IN cord-006856-b1w25ob5 461 24 the the DT cord-006856-b1w25ob5 461 25 therapy therapy NN cord-006856-b1w25ob5 461 26 . . . cord-006856-b1w25ob5 462 1 This this DT cord-006856-b1w25ob5 462 2 drug drug NN cord-006856-b1w25ob5 462 3 therapy therapy NN cord-006856-b1w25ob5 462 4 was be VBD cord-006856-b1w25ob5 462 5 continued continue VBN cord-006856-b1w25ob5 462 6 for for IN cord-006856-b1w25ob5 462 7 5 5 CD cord-006856-b1w25ob5 462 8 days day NNS cord-006856-b1w25ob5 462 9 . . . cord-006856-b1w25ob5 463 1 Of of IN cord-006856-b1w25ob5 463 2 note note NN cord-006856-b1w25ob5 463 3 is be VBZ cord-006856-b1w25ob5 463 4 the the DT cord-006856-b1w25ob5 463 5 fact fact NN cord-006856-b1w25ob5 463 6 that that IN cord-006856-b1w25ob5 463 7 with with IN cord-006856-b1w25ob5 463 8 initiation initiation NN cord-006856-b1w25ob5 463 9 of of IN cord-006856-b1w25ob5 463 10 rATG ratg JJ cord-006856-b1w25ob5 463 11 , , , cord-006856-b1w25ob5 463 12 cardiac cardiac JJ cord-006856-b1w25ob5 463 13 fibrillation fibrillation NN cord-006856-b1w25ob5 463 14 episodes episode NNS cord-006856-b1w25ob5 463 15 abated abate VBD cord-006856-b1w25ob5 463 16 immediately immediately RB cord-006856-b1w25ob5 463 17 . . . cord-006856-b1w25ob5 464 1 Routinely routinely RB cord-006856-b1w25ob5 464 2 performed perform VBN cord-006856-b1w25ob5 464 3 echo echo NN cord-006856-b1w25ob5 464 4 - - HYPH cord-006856-b1w25ob5 464 5 cardiography cardiography NN cord-006856-b1w25ob5 464 6 ( ( -LRB- cord-006856-b1w25ob5 464 7 TEE tee NN cord-006856-b1w25ob5 464 8 ) ) -RRB- cord-006856-b1w25ob5 464 9 revealed reveal VBD cord-006856-b1w25ob5 464 10 an an DT cord-006856-b1w25ob5 464 11 improvement improvement NN cord-006856-b1w25ob5 464 12 in in IN cord-006856-b1w25ob5 464 13 ventricular ventricular JJ cord-006856-b1w25ob5 464 14 function function NN cord-006856-b1w25ob5 464 15 , , , cord-006856-b1w25ob5 464 16 and and CC cord-006856-b1w25ob5 464 17 one one CD cord-006856-b1w25ob5 464 18 week week NN cord-006856-b1w25ob5 464 19 after after IN cord-006856-b1w25ob5 464 20 ECMO ECMO NNP cord-006856-b1w25ob5 464 21 support support NN cord-006856-b1w25ob5 464 22 , , , cord-006856-b1w25ob5 464 23 we -PRON- PRP cord-006856-b1w25ob5 464 24 were be VBD cord-006856-b1w25ob5 464 25 able able JJ cord-006856-b1w25ob5 464 26 to to TO cord-006856-b1w25ob5 464 27 wean wean VB cord-006856-b1w25ob5 464 28 the the DT cord-006856-b1w25ob5 464 29 patient patient NN cord-006856-b1w25ob5 464 30 from from IN cord-006856-b1w25ob5 464 31 extracorporeal extracorporeal JJ cord-006856-b1w25ob5 464 32 support support NN cord-006856-b1w25ob5 464 33 . . . cord-006856-b1w25ob5 465 1 Moreover moreover RB cord-006856-b1w25ob5 465 2 , , , cord-006856-b1w25ob5 465 3 a a DT cord-006856-b1w25ob5 465 4 routine routine JJ cord-006856-b1w25ob5 465 5 biopsy biopsy NN cord-006856-b1w25ob5 465 6 after after IN cord-006856-b1w25ob5 465 7 14 14 CD cord-006856-b1w25ob5 465 8 days day NNS cord-006856-b1w25ob5 465 9 revealed reveal VBD cord-006856-b1w25ob5 465 10 complete complete JJ cord-006856-b1w25ob5 465 11 remission remission NN cord-006856-b1w25ob5 465 12 of of IN cord-006856-b1w25ob5 465 13 GCM GCM NNP cord-006856-b1w25ob5 465 14 in in IN cord-006856-b1w25ob5 465 15 the the DT cord-006856-b1w25ob5 465 16 heart heart NN cord-006856-b1w25ob5 465 17 tissue tissue NN cord-006856-b1w25ob5 465 18 . . . cord-006856-b1w25ob5 466 1 An an DT cord-006856-b1w25ob5 466 2 intracardial intracardial JJ cord-006856-b1w25ob5 466 3 defibrillator defibrillator NN cord-006856-b1w25ob5 466 4 ( ( -LRB- cord-006856-b1w25ob5 466 5 ICD ICD NNP cord-006856-b1w25ob5 466 6 ) ) -RRB- cord-006856-b1w25ob5 466 7 was be VBD cord-006856-b1w25ob5 466 8 additionally additionally RB cord-006856-b1w25ob5 466 9 implanted implant VBN cord-006856-b1w25ob5 466 10 . . . cord-006856-b1w25ob5 467 1 Three three CD cord-006856-b1w25ob5 467 2 months month NNS cord-006856-b1w25ob5 467 3 after after IN cord-006856-b1w25ob5 467 4 emergency emergency NN cord-006856-b1w25ob5 467 5 admission admission NN cord-006856-b1w25ob5 467 6 to to IN cord-006856-b1w25ob5 467 7 our -PRON- PRP$ cord-006856-b1w25ob5 467 8 department department NN cord-006856-b1w25ob5 467 9 the the DT cord-006856-b1w25ob5 467 10 patient patient NN cord-006856-b1w25ob5 467 11 was be VBD cord-006856-b1w25ob5 467 12 discharged discharge VBN cord-006856-b1w25ob5 467 13 . . . cord-006856-b1w25ob5 468 1 Continuous continuous JJ cord-006856-b1w25ob5 468 2 medication medication NN cord-006856-b1w25ob5 468 3 of of IN cord-006856-b1w25ob5 468 4 Prednisolon Prednisolon NNP cord-006856-b1w25ob5 468 5 5 5 CD cord-006856-b1w25ob5 468 6 mg mg NNP cord-006856-b1w25ob5 468 7 / / SYM cord-006856-b1w25ob5 468 8 d d XX cord-006856-b1w25ob5 468 9 , , , cord-006856-b1w25ob5 468 10 Mycophenolat Mycophenolat NNP cord-006856-b1w25ob5 468 11 mofetil mofetil NNP cord-006856-b1w25ob5 469 1 500 500 CD cord-006856-b1w25ob5 469 2 mg mg NNP cord-006856-b1w25ob5 469 3 / / SYM cord-006856-b1w25ob5 469 4 d d NNP cord-006856-b1w25ob5 469 5 , , , cord-006856-b1w25ob5 469 6 and and CC cord-006856-b1w25ob5 469 7 Plavix Plavix NNP cord-006856-b1w25ob5 469 8 75 75 CD cord-006856-b1w25ob5 469 9 mg mg NNP cord-006856-b1w25ob5 469 10 / / SYM cord-006856-b1w25ob5 469 11 d d NNP cord-006856-b1w25ob5 469 12 was be VBD cord-006856-b1w25ob5 469 13 prescribed prescribe VBN cord-006856-b1w25ob5 469 14 . . . cord-006856-b1w25ob5 470 1 12 12 CD cord-006856-b1w25ob5 470 2 month month NN cord-006856-b1w25ob5 470 3 after after IN cord-006856-b1w25ob5 470 4 initial initial JJ cord-006856-b1w25ob5 470 5 event event NN cord-006856-b1w25ob5 470 6 the the DT cord-006856-b1w25ob5 470 7 patient patient NN cord-006856-b1w25ob5 470 8 describes describe VBZ cord-006856-b1w25ob5 470 9 NYHA NYHA NNP cord-006856-b1w25ob5 470 10 class class NN cord-006856-b1w25ob5 471 1 I -PRON- PRP cord-006856-b1w25ob5 471 2 heart heart NN cord-006856-b1w25ob5 471 3 function function NN cord-006856-b1w25ob5 471 4 and and CC cord-006856-b1w25ob5 471 5 echocardiography echocardiography NN cord-006856-b1w25ob5 471 6 reveals reveal VBZ cord-006856-b1w25ob5 471 7 an an DT cord-006856-b1w25ob5 471 8 moderate moderate JJ cord-006856-b1w25ob5 471 9 impairment impairment NN cord-006856-b1w25ob5 471 10 of of IN cord-006856-b1w25ob5 471 11 heart heart NN cord-006856-b1w25ob5 471 12 function function NN cord-006856-b1w25ob5 471 13 ( ( -LRB- cord-006856-b1w25ob5 471 14 EF EF NNP cord-006856-b1w25ob5 471 15 55 55 CD cord-006856-b1w25ob5 471 16 % % NN cord-006856-b1w25ob5 471 17 ) ) -RRB- cord-006856-b1w25ob5 471 18 . . . cord-006856-b1w25ob5 472 1 Immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 472 2 with with IN cord-006856-b1w25ob5 472 3 low low JJ cord-006856-b1w25ob5 472 4 - - HYPH cord-006856-b1w25ob5 472 5 dose dose NN cord-006856-b1w25ob5 472 6 steroid steroid NN cord-006856-b1w25ob5 472 7 and and CC cord-006856-b1w25ob5 472 8 Mycophenolate Mycophenolate NNP cord-006856-b1w25ob5 472 9 drug drug NN cord-006856-b1w25ob5 472 10 regimen regimen NN cord-006856-b1w25ob5 472 11 is be VBZ cord-006856-b1w25ob5 472 12 continued continue VBN cord-006856-b1w25ob5 472 13 as as IN cord-006856-b1w25ob5 472 14 the the DT cord-006856-b1w25ob5 472 15 patient patient NN cord-006856-b1w25ob5 472 16 describes describe VBZ cord-006856-b1w25ob5 472 17 no no DT cord-006856-b1w25ob5 472 18 side side NN cord-006856-b1w25ob5 472 19 effects effect NNS cord-006856-b1w25ob5 472 20 . . . cord-006856-b1w25ob5 473 1 Discussion discussion NN cord-006856-b1w25ob5 473 2 . . . cord-006856-b1w25ob5 474 1 This this DT cord-006856-b1w25ob5 474 2 report report NN cord-006856-b1w25ob5 474 3 adds add VBZ cord-006856-b1w25ob5 474 4 to to IN cord-006856-b1w25ob5 474 5 the the DT cord-006856-b1w25ob5 474 6 available available JJ cord-006856-b1w25ob5 474 7 knowledge knowledge NN cord-006856-b1w25ob5 474 8 of of IN cord-006856-b1w25ob5 474 9 giant giant JJ cord-006856-b1w25ob5 474 10 - - HYPH cord-006856-b1w25ob5 474 11 cell cell NN cord-006856-b1w25ob5 474 12 myocarditis myocarditis NN cord-006856-b1w25ob5 474 13 by by IN cord-006856-b1w25ob5 474 14 providing provide VBG cord-006856-b1w25ob5 474 15 that that DT cord-006856-b1w25ob5 474 16 ( ( -LRB- cord-006856-b1w25ob5 474 17 a a DT cord-006856-b1w25ob5 474 18 ) ) -RRB- cord-006856-b1w25ob5 474 19 ECMO ecmo NN cord-006856-b1w25ob5 474 20 implantation implantation NN cord-006856-b1w25ob5 474 21 is be VBZ cord-006856-b1w25ob5 474 22 feasible feasible JJ cord-006856-b1w25ob5 474 23 if if IN cord-006856-b1w25ob5 474 24 the the DT cord-006856-b1w25ob5 474 25 patient patient NN cord-006856-b1w25ob5 474 26 is be VBZ cord-006856-b1w25ob5 474 27 demonstrating demonstrate VBG cord-006856-b1w25ob5 474 28 acute acute JJ cord-006856-b1w25ob5 474 29 haemodynamic haemodynamic JJ cord-006856-b1w25ob5 474 30 deterioration deterioration NN cord-006856-b1w25ob5 474 31 because because IN cord-006856-b1w25ob5 474 32 of of IN cord-006856-b1w25ob5 474 33 biventricular biventricular JJ cord-006856-b1w25ob5 474 34 dilation dilation NN cord-006856-b1w25ob5 474 35 and and CC cord-006856-b1w25ob5 474 36 medically medically RB cord-006856-b1w25ob5 474 37 intractable intractable JJ cord-006856-b1w25ob5 474 38 ventricular ventricular JJ cord-006856-b1w25ob5 474 39 fibrillation fibrillation NN cord-006856-b1w25ob5 474 40 and and CC cord-006856-b1w25ob5 474 41 ( ( -LRB- cord-006856-b1w25ob5 474 42 b b NN cord-006856-b1w25ob5 474 43 ) ) -RRB- cord-006856-b1w25ob5 474 44 after after IN cord-006856-b1w25ob5 474 45 verified verify VBN cord-006856-b1w25ob5 474 46 histological histological JJ cord-006856-b1w25ob5 474 47 diagnosis diagnosis NN cord-006856-b1w25ob5 474 48 of of IN cord-006856-b1w25ob5 474 49 GCM GCM NNP cord-006856-b1w25ob5 474 50 immunemodulation immunemodulation NN cord-006856-b1w25ob5 474 51 with with IN cord-006856-b1w25ob5 474 52 cyclosporine cyclosporine NN cord-006856-b1w25ob5 474 53 / / SYM cord-006856-b1w25ob5 474 54 mycophenolate mycophenolate NN cord-006856-b1w25ob5 474 55 with with IN cord-006856-b1w25ob5 474 56 additional additional JJ cord-006856-b1w25ob5 474 57 application application NN cord-006856-b1w25ob5 474 58 of of IN cord-006856-b1w25ob5 474 59 rATG rATG NNP cord-006856-b1w25ob5 474 60 is be VBZ cord-006856-b1w25ob5 474 61 feasible feasible JJ cord-006856-b1w25ob5 474 62 with with IN cord-006856-b1w25ob5 474 63 favourable favourable JJ cord-006856-b1w25ob5 474 64 outcome outcome NN cord-006856-b1w25ob5 474 65 . . . cord-006856-b1w25ob5 475 1 In in IN cord-006856-b1w25ob5 475 2 various various JJ cord-006856-b1w25ob5 475 3 studies study NNS cord-006856-b1w25ob5 475 4 , , , cord-006856-b1w25ob5 475 5 patients patient NNS cord-006856-b1w25ob5 475 6 with with IN cord-006856-b1w25ob5 475 7 GCM GCM NNP cord-006856-b1w25ob5 475 8 were be VBD cord-006856-b1w25ob5 475 9 treated treat VBN cord-006856-b1w25ob5 475 10 with with IN cord-006856-b1w25ob5 475 11 immunosuppression immunosuppression NN cord-006856-b1w25ob5 475 12 ( ( -LRB- cord-006856-b1w25ob5 475 13 cyclosporine cyclosporine NN cord-006856-b1w25ob5 475 14 , , , cord-006856-b1w25ob5 475 15 steroids steroid NNS cord-006856-b1w25ob5 475 16 , , , cord-006856-b1w25ob5 475 17 murine murine JJ cord-006856-b1w25ob5 475 18 monoclonal monoclonal JJ cord-006856-b1w25ob5 475 19 antibodies antibody NNS cord-006856-b1w25ob5 475 20 [ [ -LRB- cord-006856-b1w25ob5 475 21 OKT-3 OKT-3 NNP cord-006856-b1w25ob5 475 22 ] ] -RRB- cord-006856-b1w25ob5 475 23 ) ) -RRB- cord-006856-b1w25ob5 475 24 and and CC cord-006856-b1w25ob5 475 25 even even RB cord-006856-b1w25ob5 475 26 assist assist VB cord-006856-b1w25ob5 475 27 device device NN cord-006856-b1w25ob5 475 28 as as IN cord-006856-b1w25ob5 475 29 bridge bridge NN cord-006856-b1w25ob5 475 30 to to IN cord-006856-b1w25ob5 475 31 transplantation transplantation NN cord-006856-b1w25ob5 475 32 . . . cord-006856-b1w25ob5 476 1 Heart heart NN cord-006856-b1w25ob5 476 2 transplantation transplantation NN cord-006856-b1w25ob5 476 3 has have VBZ cord-006856-b1w25ob5 476 4 shown show VBN cord-006856-b1w25ob5 476 5 to to TO cord-006856-b1w25ob5 476 6 be be VB cord-006856-b1w25ob5 476 7 successful successful JJ cord-006856-b1w25ob5 476 8 as as IN cord-006856-b1w25ob5 476 9 method method NN cord-006856-b1w25ob5 476 10 of of IN cord-006856-b1w25ob5 476 11 treatment treatment NN cord-006856-b1w25ob5 476 12 . . . cord-006856-b1w25ob5 477 1 Autoimmune autoimmune JJ cord-006856-b1w25ob5 477 2 diseases disease NNS cord-006856-b1w25ob5 477 3 and and CC cord-006856-b1w25ob5 477 4 its -PRON- PRP$ cord-006856-b1w25ob5 477 5 mechanisms mechanism NNS cord-006856-b1w25ob5 477 6 were be VBD cord-006856-b1w25ob5 477 7 suggested suggest VBN cord-006856-b1w25ob5 477 8 to to TO cord-006856-b1w25ob5 477 9 be be VB cord-006856-b1w25ob5 477 10 involved involve VBN cord-006856-b1w25ob5 477 11 in in IN cord-006856-b1w25ob5 477 12 the the DT cord-006856-b1w25ob5 477 13 pathogenesis pathogenesis NN cord-006856-b1w25ob5 477 14 of of IN cord-006856-b1w25ob5 477 15 GCM GCM NNP cord-006856-b1w25ob5 477 16 . . . cord-006856-b1w25ob5 478 1 Most most RBS cord-006856-b1w25ob5 478 2 recently recently RB cord-006856-b1w25ob5 478 3 , , , cord-006856-b1w25ob5 478 4 a a DT cord-006856-b1w25ob5 478 5 novel novel JJ cord-006856-b1w25ob5 478 6 mechanism mechanism NN cord-006856-b1w25ob5 478 7 of of IN cord-006856-b1w25ob5 478 8 action action NN cord-006856-b1w25ob5 478 9 of of IN cord-006856-b1w25ob5 478 10 immunoglobulin immunoglobulin NN cord-006856-b1w25ob5 478 11 was be VBD cord-006856-b1w25ob5 478 12 proposed propose VBN cord-006856-b1w25ob5 478 13 to to TO cord-006856-b1w25ob5 478 14 be be VB cord-006856-b1w25ob5 478 15 due due JJ cord-006856-b1w25ob5 478 16 to to IN cord-006856-b1w25ob5 478 17 anti anti JJ cord-006856-b1w25ob5 478 18 - - JJ cord-006856-b1w25ob5 478 19 inflammatory inflammatory JJ cord-006856-b1w25ob5 478 20 activities activity NNS cord-006856-b1w25ob5 478 21 through through IN cord-006856-b1w25ob5 478 22 the the DT cord-006856-b1w25ob5 478 23 inhibitory inhibitory JJ cord-006856-b1w25ob5 478 24 Fc Fc NNP cord-006856-b1w25ob5 478 25 receptos receptos NN cord-006856-b1w25ob5 478 26 ( ( -LRB- cord-006856-b1w25ob5 478 27 FcRs FcRs NNP cord-006856-b1w25ob5 478 28 ) ) -RRB- cord-006856-b1w25ob5 478 29 . . . cord-006856-b1w25ob5 479 1 It -PRON- PRP cord-006856-b1w25ob5 479 2 has have VBZ cord-006856-b1w25ob5 479 3 been be VBN cord-006856-b1w25ob5 479 4 suggested suggest VBN cord-006856-b1w25ob5 479 5 that that IN cord-006856-b1w25ob5 479 6 T t NN cord-006856-b1w25ob5 479 7 - - HYPH cord-006856-b1w25ob5 479 8 cell cell NN cord-006856-b1w25ob5 479 9 - - HYPH cord-006856-b1w25ob5 479 10 mediated mediate VBN cord-006856-b1w25ob5 479 11 autoimmune autoimmune JJ cord-006856-b1w25ob5 479 12 diseases disease NNS cord-006856-b1w25ob5 479 13 is be VBZ cord-006856-b1w25ob5 479 14 the the DT cord-006856-b1w25ob5 479 15 result result NN cord-006856-b1w25ob5 479 16 of of IN cord-006856-b1w25ob5 479 17 inappropriate inappropriate JJ cord-006856-b1w25ob5 479 18 antigen antigen NN cord-006856-b1w25ob5 479 19 presentation presentation NN cord-006856-b1w25ob5 479 20 of of IN cord-006856-b1w25ob5 479 21 either either CC cord-006856-b1w25ob5 479 22 a a DT cord-006856-b1w25ob5 479 23 self self NN cord-006856-b1w25ob5 479 24 - - HYPH cord-006856-b1w25ob5 479 25 antigen antigen NN cord-006856-b1w25ob5 479 26 or or CC cord-006856-b1w25ob5 479 27 an an DT cord-006856-b1w25ob5 479 28 antigen antigen NN cord-006856-b1w25ob5 479 29 with with IN cord-006856-b1w25ob5 479 30 the the DT cord-006856-b1w25ob5 479 31 capacity capacity NN cord-006856-b1w25ob5 479 32 to to TO cord-006856-b1w25ob5 479 33 mimic mimic VB cord-006856-b1w25ob5 479 34 a a DT cord-006856-b1w25ob5 479 35 self self NN cord-006856-b1w25ob5 479 36 - - HYPH cord-006856-b1w25ob5 479 37 antigen antigen NN cord-006856-b1w25ob5 479 38 in in IN cord-006856-b1w25ob5 479 39 the the DT cord-006856-b1w25ob5 479 40 peripheral peripheral JJ cord-006856-b1w25ob5 479 41 lymphoid lymphoid JJ cord-006856-b1w25ob5 479 42 tissues tissue NNS cord-006856-b1w25ob5 479 43 . . . cord-006856-b1w25ob5 480 1 Relevant relevant JJ cord-006856-b1w25ob5 480 2 to to IN cord-006856-b1w25ob5 480 3 this this DT cord-006856-b1w25ob5 480 4 novel novel JJ cord-006856-b1w25ob5 480 5 application application NN cord-006856-b1w25ob5 480 6 of of IN cord-006856-b1w25ob5 480 7 rATG ratg JJ cord-006856-b1w25ob5 480 8 , , , cord-006856-b1w25ob5 480 9 polyclonal polyclonal JJ cord-006856-b1w25ob5 480 10 suspensions suspension NNS cord-006856-b1w25ob5 480 11 like like IN cord-006856-b1w25ob5 480 12 IgM IgM NNP cord-006856-b1w25ob5 480 13 / / SYM cord-006856-b1w25ob5 480 14 G G NNP cord-006856-b1w25ob5 480 15 , , , cord-006856-b1w25ob5 480 16 IVIg IVIg NNP cord-006856-b1w25ob5 480 17 containing contain VBG cord-006856-b1w25ob5 480 18 Fc Fc NNP cord-006856-b1w25ob5 480 19 receptors receptor NNS cord-006856-b1w25ob5 480 20 and and CC cord-006856-b1w25ob5 480 21 have have VBP cord-006856-b1w25ob5 480 22 been be VBN cord-006856-b1w25ob5 480 23 demonstrated demonstrate VBN cord-006856-b1w25ob5 480 24 to to TO cord-006856-b1w25ob5 480 25 be be VB cord-006856-b1w25ob5 480 26 beneficiary beneficiary NN cord-006856-b1w25ob5 480 27 in in IN cord-006856-b1w25ob5 480 28 autoimmune autoimmune JJ cord-006856-b1w25ob5 480 29 myocarditis myocarditis NN cord-006856-b1w25ob5 480 30 . . . cord-006856-b1w25ob5 481 1 In in IN cord-006856-b1w25ob5 481 2 an an DT cord-006856-b1w25ob5 481 3 elegant elegant JJ cord-006856-b1w25ob5 481 4 study study NN cord-006856-b1w25ob5 481 5 by by IN cord-006856-b1w25ob5 481 6 Shioji Shioji NNP cord-006856-b1w25ob5 481 7 et et NNP cord-006856-b1w25ob5 481 8 al al NNP cord-006856-b1w25ob5 481 9 . . . cord-006856-b1w25ob5 482 1 IVIg IVIg NNP cord-006856-b1w25ob5 482 2 was be VBD cord-006856-b1w25ob5 482 3 highly highly RB cord-006856-b1w25ob5 482 4 effective effective JJ cord-006856-b1w25ob5 482 5 in in IN cord-006856-b1w25ob5 482 6 ameliorating ameliorate VBG cord-006856-b1w25ob5 482 7 experimental experimental JJ cord-006856-b1w25ob5 482 8 myocarditis myocarditis NN cord-006856-b1w25ob5 482 9 . . . cord-006856-b1w25ob5 483 1 However however RB cord-006856-b1w25ob5 483 2 it -PRON- PRP cord-006856-b1w25ob5 483 3 has have VBZ cord-006856-b1w25ob5 483 4 to to TO cord-006856-b1w25ob5 483 5 be be VB cord-006856-b1w25ob5 483 6 mentioned mention VBN cord-006856-b1w25ob5 483 7 that that IN cord-006856-b1w25ob5 483 8 immunoglobulin immunoglobulin NN cord-006856-b1w25ob5 483 9 treatment treatment NN cord-006856-b1w25ob5 483 10 failed fail VBD cord-006856-b1w25ob5 483 11 to to TO cord-006856-b1w25ob5 483 12 ameliorate ameliorate VB cord-006856-b1w25ob5 483 13 myocarditis myocarditis NN cord-006856-b1w25ob5 483 14 . . . cord-006856-b1w25ob5 484 1 In in IN cord-006856-b1w25ob5 484 2 respect respect NN cord-006856-b1w25ob5 484 3 to to IN cord-006856-b1w25ob5 484 4 our -PRON- PRP$ cord-006856-b1w25ob5 484 5 patient patient NN cord-006856-b1w25ob5 484 6 suffering suffering NN cord-006856-b1w25ob5 484 7 of of IN cord-006856-b1w25ob5 484 8 RCM RCM NNP cord-006856-b1w25ob5 484 9 Fc Fc NNP cord-006856-b1w25ob5 484 10 containing contain VBG cord-006856-b1w25ob5 484 11 rATG ratg JJ cord-006856-b1w25ob5 484 12 provided provide VBN cord-006856-b1w25ob5 484 13 remarkable remarkable JJ cord-006856-b1w25ob5 484 14 clinical clinical JJ cord-006856-b1w25ob5 484 15 benefit benefit NN cord-006856-b1w25ob5 484 16 . . . cord-006856-b1w25ob5 485 1 Background background NN cord-006856-b1w25ob5 485 2 . . . cord-006856-b1w25ob5 486 1 The the DT cord-006856-b1w25ob5 486 2 criteria criterion NNS cord-006856-b1w25ob5 486 3 for for IN cord-006856-b1w25ob5 486 4 liver liver NN cord-006856-b1w25ob5 486 5 donation donation NN cord-006856-b1w25ob5 486 6 have have VBP cord-006856-b1w25ob5 486 7 been be VBN cord-006856-b1w25ob5 486 8 widely widely RB cord-006856-b1w25ob5 486 9 extended extend VBN cord-006856-b1w25ob5 486 10 due due IN cord-006856-b1w25ob5 486 11 to to IN cord-006856-b1w25ob5 486 12 the the DT cord-006856-b1w25ob5 486 13 increasing increase VBG cord-006856-b1w25ob5 486 14 waiting wait VBG cord-006856-b1w25ob5 486 15 time time NN cord-006856-b1w25ob5 486 16 and and CC cord-006856-b1w25ob5 486 17 waiting waiting NN cord-006856-b1w25ob5 486 18 list list NN cord-006856-b1w25ob5 486 19 mortality mortality NN cord-006856-b1w25ob5 486 20 . . . cord-006856-b1w25ob5 487 1 Marginal marginal JJ cord-006856-b1w25ob5 487 2 donors donor NNS cord-006856-b1w25ob5 487 3 provide provide VBP cord-006856-b1w25ob5 487 4 an an DT cord-006856-b1w25ob5 487 5 upcoming upcoming JJ cord-006856-b1w25ob5 487 6 option option NN cord-006856-b1w25ob5 487 7 to to TO cord-006856-b1w25ob5 487 8 diminish diminish VB cord-006856-b1w25ob5 487 9 the the DT cord-006856-b1w25ob5 487 10 number number NN cord-006856-b1w25ob5 487 11 of of IN cord-006856-b1w25ob5 487 12 waiting wait VBG cord-006856-b1w25ob5 487 13 patients patient NNS cord-006856-b1w25ob5 487 14 . . . cord-006856-b1w25ob5 488 1 Methods method NNS cord-006856-b1w25ob5 488 2 . . . cord-006856-b1w25ob5 489 1 The the DT cord-006856-b1w25ob5 489 2 criteria criterion NNS cord-006856-b1w25ob5 489 3 for for IN cord-006856-b1w25ob5 489 4 marginal marginal JJ cord-006856-b1w25ob5 489 5 were be VBD cord-006856-b1w25ob5 489 6 ICU ICU NNP cord-006856-b1w25ob5 489 7 stay stay NN cord-006856-b1w25ob5 489 8 of of IN cord-006856-b1w25ob5 489 9 > > NN cord-006856-b1w25ob5 489 10 7 7 CD cord-006856-b1w25ob5 489 11 days day NNS cord-006856-b1w25ob5 489 12 , , , cord-006856-b1w25ob5 489 13 age age NN cord-006856-b1w25ob5 489 14 of of IN cord-006856-b1w25ob5 489 15 > > XX cord-006856-b1w25ob5 489 16 65 65 CD cord-006856-b1w25ob5 489 17 years year NNS cord-006856-b1w25ob5 489 18 , , , cord-006856-b1w25ob5 489 19 BMI BMI NNP cord-006856-b1w25ob5 489 20 of of IN cord-006856-b1w25ob5 489 21 > > NNP cord-006856-b1w25ob5 489 22 27 27 CD cord-006856-b1w25ob5 489 23 , , , cord-006856-b1w25ob5 489 24 alcohol alcohol NN cord-006856-b1w25ob5 489 25 or or CC cord-006856-b1w25ob5 489 26 oral oral JJ cord-006856-b1w25ob5 489 27 drug drug NN cord-006856-b1w25ob5 489 28 abuse abuse NN cord-006856-b1w25ob5 489 29 , , , cord-006856-b1w25ob5 489 30 infection infection NN cord-006856-b1w25ob5 489 31 , , , cord-006856-b1w25ob5 489 32 hypernatremia hypernatremia NN cord-006856-b1w25ob5 490 1 ( ( -LRB- cord-006856-b1w25ob5 490 2 Na na UH cord-006856-b1w25ob5 490 3 , , , cord-006856-b1w25ob5 490 4 > > XX cord-006856-b1w25ob5 490 5 150 150 CD cord-006856-b1w25ob5 490 6 mg mg NNP cord-006856-b1w25ob5 490 7 / / SYM cord-006856-b1w25ob5 490 8 dl dl NNP cord-006856-b1w25ob5 490 9 ) ) -RRB- cord-006856-b1w25ob5 490 10 , , , cord-006856-b1w25ob5 490 11 high high JJ cord-006856-b1w25ob5 490 12 liver liver NN cord-006856-b1w25ob5 490 13 enzymes enzyme NNS cord-006856-b1w25ob5 490 14 ( ( -LRB- cord-006856-b1w25ob5 490 15 AST AST NNP cord-006856-b1w25ob5 490 16 , , , cord-006856-b1w25ob5 490 17 ALT alt NN cord-006856-b1w25ob5 490 18 2 2 CD cord-006856-b1w25ob5 490 19 times time NNS cord-006856-b1w25ob5 490 20 the the DT cord-006856-b1w25ob5 490 21 normal normal JJ cord-006856-b1w25ob5 490 22 ) ) -RRB- cord-006856-b1w25ob5 490 23 , , , cord-006856-b1w25ob5 490 24 liver liver NN cord-006856-b1w25ob5 490 25 parenchymal parenchymal NN cord-006856-b1w25ob5 490 26 damage damage NN cord-006856-b1w25ob5 490 27 and and CC cord-006856-b1w25ob5 490 28 metabolic metabolic JJ cord-006856-b1w25ob5 490 29 diseases disease NNS cord-006856-b1w25ob5 490 30 . . . cord-006856-b1w25ob5 491 1 From from IN cord-006856-b1w25ob5 491 2 01/00 01/00 CD cord-006856-b1w25ob5 491 3 until until IN cord-006856-b1w25ob5 491 4 06/05 06/05 CD cord-006856-b1w25ob5 491 5 our -PRON- PRP$ cord-006856-b1w25ob5 491 6 center center NN cord-006856-b1w25ob5 491 7 reported report VBD cord-006856-b1w25ob5 491 8 55 55 CD cord-006856-b1w25ob5 491 9 donors donor NNS cord-006856-b1w25ob5 491 10 , , , cord-006856-b1w25ob5 491 11 who who WP cord-006856-b1w25ob5 491 12 fulfilled fulfil VBD cord-006856-b1w25ob5 491 13 at at IN cord-006856-b1w25ob5 491 14 least least JJS cord-006856-b1w25ob5 491 15 3 3 CD cord-006856-b1w25ob5 491 16 of of IN cord-006856-b1w25ob5 491 17 the the DT cord-006856-b1w25ob5 491 18 above above JJ cord-006856-b1w25ob5 491 19 criteria criterion NNS cord-006856-b1w25ob5 491 20 . . . cord-006856-b1w25ob5 492 1 Results result NNS cord-006856-b1w25ob5 492 2 . . . cord-006856-b1w25ob5 493 1 All all DT cord-006856-b1w25ob5 493 2 livers liver NNS cord-006856-b1w25ob5 493 3 were be VBD cord-006856-b1w25ob5 493 4 transplanted transplant VBN cord-006856-b1w25ob5 493 5 either either CC cord-006856-b1w25ob5 493 6 in in IN cord-006856-b1w25ob5 493 7 standard standard NN cord-006856-b1w25ob5 493 8 or or CC cord-006856-b1w25ob5 493 9 in in IN cord-006856-b1w25ob5 493 10 piggyback piggyback NN cord-006856-b1w25ob5 493 11 technique technique NN cord-006856-b1w25ob5 493 12 with with IN cord-006856-b1w25ob5 493 13 a a DT cord-006856-b1w25ob5 493 14 cold cold JJ cord-006856-b1w25ob5 493 15 ischemic ischemic JJ cord-006856-b1w25ob5 493 16 period period NN cord-006856-b1w25ob5 493 17 between between IN cord-006856-b1w25ob5 493 18 130 130 CD cord-006856-b1w25ob5 493 19 minutes minute NNS cord-006856-b1w25ob5 493 20 and and CC cord-006856-b1w25ob5 493 21 12 12 CD cord-006856-b1w25ob5 493 22 hours hour NNS cord-006856-b1w25ob5 493 23 . . . cord-006856-b1w25ob5 494 1 The the DT cord-006856-b1w25ob5 494 2 mean mean JJ cord-006856-b1w25ob5 494 3 recipient recipient NN cord-006856-b1w25ob5 494 4 age age NN cord-006856-b1w25ob5 494 5 was be VBD cord-006856-b1w25ob5 494 6 45 45 CD cord-006856-b1w25ob5 494 7 ( ( -LRB- cord-006856-b1w25ob5 494 8 13 13 CD cord-006856-b1w25ob5 494 9 - - SYM cord-006856-b1w25ob5 494 10 75 75 CD cord-006856-b1w25ob5 494 11 ) ) -RRB- cord-006856-b1w25ob5 494 12 years year NNS cord-006856-b1w25ob5 494 13 . . . cord-006856-b1w25ob5 495 1 6 6 CD cord-006856-b1w25ob5 495 2 livers liver NNS cord-006856-b1w25ob5 495 3 were be VBD cord-006856-b1w25ob5 495 4 used use VBN cord-006856-b1w25ob5 495 5 for for IN cord-006856-b1w25ob5 495 6 HU HU NNP cord-006856-b1w25ob5 495 7 patients patient NNS cord-006856-b1w25ob5 495 8 , , , cord-006856-b1w25ob5 495 9 5 5 CD cord-006856-b1w25ob5 495 10 for for IN cord-006856-b1w25ob5 495 11 a a DT cord-006856-b1w25ob5 495 12 retransplantation retransplantation NN cord-006856-b1w25ob5 495 13 , , , cord-006856-b1w25ob5 495 14 2 2 CD cord-006856-b1w25ob5 495 15 were be VBD cord-006856-b1w25ob5 495 16 implanted implant VBN cord-006856-b1w25ob5 495 17 in in IN cord-006856-b1w25ob5 495 18 combination combination NN cord-006856-b1w25ob5 495 19 with with IN cord-006856-b1w25ob5 495 20 kidneys kidney NNS cord-006856-b1w25ob5 495 21 , , , cord-006856-b1w25ob5 495 22 and and CC cord-006856-b1w25ob5 495 23 37 37 CD cord-006856-b1w25ob5 495 24 organs organ NNS cord-006856-b1w25ob5 495 25 were be VBD cord-006856-b1w25ob5 495 26 transplanted transplant VBN cord-006856-b1w25ob5 495 27 electively electively RB cord-006856-b1w25ob5 495 28 . . . cord-006856-b1w25ob5 496 1 Primary primary JJ cord-006856-b1w25ob5 496 2 diseases disease NNS cord-006856-b1w25ob5 496 3 were be VBD cord-006856-b1w25ob5 496 4 cryptogenic cryptogenic JJ cord-006856-b1w25ob5 496 5 cirrhosis cirrhosis NN cord-006856-b1w25ob5 496 6 , , , cord-006856-b1w25ob5 496 7 Hepatocellular Hepatocellular NNP cord-006856-b1w25ob5 496 8 carcinoma carcinoma NN cord-006856-b1w25ob5 496 9 , , , cord-006856-b1w25ob5 496 10 post post JJ cord-006856-b1w25ob5 496 11 - - JJ cord-006856-b1w25ob5 496 12 hepatitis hepatitis JJ cord-006856-b1w25ob5 496 13 cirrhosis cirrhosis NN cord-006856-b1w25ob5 496 14 , , , cord-006856-b1w25ob5 496 15 polycystic polycystic JJ cord-006856-b1w25ob5 496 16 liver liver NN cord-006856-b1w25ob5 496 17 disease disease NN cord-006856-b1w25ob5 496 18 , , , cord-006856-b1w25ob5 496 19 scleroting sclerote VBG cord-006856-b1w25ob5 496 20 bile bile NN cord-006856-b1w25ob5 496 21 ducts duct NNS cord-006856-b1w25ob5 496 22 , , , cord-006856-b1w25ob5 496 23 hepatic hepatic JJ cord-006856-b1w25ob5 496 24 artery artery NN cord-006856-b1w25ob5 496 25 thrombosis thrombosis NN cord-006856-b1w25ob5 496 26 , , , cord-006856-b1w25ob5 496 27 and and CC cord-006856-b1w25ob5 496 28 acute acute JJ cord-006856-b1w25ob5 496 29 liver liver NN cord-006856-b1w25ob5 496 30 failure failure NN cord-006856-b1w25ob5 496 31 . . . cord-006856-b1w25ob5 497 1 2 2 CD cord-006856-b1w25ob5 497 2 month month NN cord-006856-b1w25ob5 497 3 after after IN cord-006856-b1w25ob5 497 4 transplantation transplantation NN cord-006856-b1w25ob5 497 5 , , , cord-006856-b1w25ob5 497 6 54 54 CD cord-006856-b1w25ob5 497 7 recipients recipient NNS cord-006856-b1w25ob5 497 8 were be VBD cord-006856-b1w25ob5 497 9 alive alive JJ cord-006856-b1w25ob5 497 10 , , , cord-006856-b1w25ob5 497 11 1 1 CD cord-006856-b1w25ob5 497 12 died die VBD cord-006856-b1w25ob5 497 13 1 1 CD cord-006856-b1w25ob5 497 14 month month NN cord-006856-b1w25ob5 497 15 after after IN cord-006856-b1w25ob5 497 16 TX TX NNP cord-006856-b1w25ob5 497 17 not not RB cord-006856-b1w25ob5 497 18 transplant transplant NN cord-006856-b1w25ob5 497 19 related relate VBN cord-006856-b1w25ob5 497 20 . . . cord-006856-b1w25ob5 498 1 16 16 CD cord-006856-b1w25ob5 498 2 livers liver NNS cord-006856-b1w25ob5 498 3 were be VBD cord-006856-b1w25ob5 498 4 implanted implant VBN cord-006856-b1w25ob5 498 5 at at IN cord-006856-b1w25ob5 498 6 our -PRON- PRP$ cord-006856-b1w25ob5 498 7 center center NN cord-006856-b1w25ob5 498 8 in in IN cord-006856-b1w25ob5 498 9 piggyback piggyback NN cord-006856-b1w25ob5 498 10 technique technique NN cord-006856-b1w25ob5 498 11 with with IN cord-006856-b1w25ob5 498 12 retrograde retrograde JJ cord-006856-b1w25ob5 498 13 reperfusion reperfusion NN cord-006856-b1w25ob5 498 14 . . . cord-006856-b1w25ob5 499 1 15 15 CD cord-006856-b1w25ob5 499 2 patients patient NNS cord-006856-b1w25ob5 499 3 were be VBD cord-006856-b1w25ob5 499 4 elective elective JJ cord-006856-b1w25ob5 499 5 patients patient NNS cord-006856-b1w25ob5 499 6 in in IN cord-006856-b1w25ob5 499 7 good good JJ cord-006856-b1w25ob5 499 8 or or CC cord-006856-b1w25ob5 499 9 moderate moderate JJ cord-006856-b1w25ob5 499 10 condition condition NN cord-006856-b1w25ob5 499 11 , , , cord-006856-b1w25ob5 499 12 1 1 CD cord-006856-b1w25ob5 499 13 patient patient NN cord-006856-b1w25ob5 499 14 was be VBD cord-006856-b1w25ob5 499 15 a a DT cord-006856-b1w25ob5 499 16 HU HU NNP cord-006856-b1w25ob5 499 17 patient patient NN cord-006856-b1w25ob5 499 18 suffering suffer VBG cord-006856-b1w25ob5 499 19 a a DT cord-006856-b1w25ob5 499 20 hepatic hepatic JJ cord-006856-b1w25ob5 499 21 artery artery NN cord-006856-b1w25ob5 499 22 thrombosis thrombosis NN cord-006856-b1w25ob5 499 23 . . . cord-006856-b1w25ob5 500 1 The the DT cord-006856-b1w25ob5 500 2 initial initial JJ cord-006856-b1w25ob5 500 3 graft graft NN cord-006856-b1w25ob5 500 4 function function NN cord-006856-b1w25ob5 500 5 was be VBD cord-006856-b1w25ob5 500 6 good good JJ cord-006856-b1w25ob5 500 7 ( ( -LRB- cord-006856-b1w25ob5 500 8 GOT got VB cord-006856-b1w25ob5 500 9 , , , cord-006856-b1w25ob5 500 10 < < XX cord-006856-b1w25ob5 500 11 1000 1000 CD cord-006856-b1w25ob5 500 12 mg mg NNP cord-006856-b1w25ob5 500 13 / / SYM cord-006856-b1w25ob5 500 14 dl dl NNP cord-006856-b1w25ob5 500 15 pod pod NNP cord-006856-b1w25ob5 500 16 1 1 CD cord-006856-b1w25ob5 500 17 ) ) -RRB- cord-006856-b1w25ob5 500 18 in in IN cord-006856-b1w25ob5 500 19 8 8 CD cord-006856-b1w25ob5 500 20 , , , cord-006856-b1w25ob5 500 21 moderate moderate JJ cord-006856-b1w25ob5 500 22 ( ( -LRB- cord-006856-b1w25ob5 500 23 GOT got VB cord-006856-b1w25ob5 500 24 , , , cord-006856-b1w25ob5 500 25 1000 1000 CD cord-006856-b1w25ob5 500 26 - - SYM cord-006856-b1w25ob5 500 27 2000 2000 CD cord-006856-b1w25ob5 500 28 mg mg NNP cord-006856-b1w25ob5 500 29 / / SYM cord-006856-b1w25ob5 500 30 dl dl NNP cord-006856-b1w25ob5 500 31 pod pod NNP cord-006856-b1w25ob5 500 32 1 1 CD cord-006856-b1w25ob5 500 33 ) ) -RRB- cord-006856-b1w25ob5 500 34 in in IN cord-006856-b1w25ob5 500 35 5 5 CD cord-006856-b1w25ob5 500 36 , , , cord-006856-b1w25ob5 500 37 and and CC cord-006856-b1w25ob5 500 38 delayed delay VBN cord-006856-b1w25ob5 500 39 ( ( -LRB- cord-006856-b1w25ob5 500 40 GOT got NN cord-006856-b1w25ob5 500 41 , , , cord-006856-b1w25ob5 500 42 > > XX cord-006856-b1w25ob5 501 1 2000 2000 CD cord-006856-b1w25ob5 501 2 mg mg NNP cord-006856-b1w25ob5 501 3 / / SYM cord-006856-b1w25ob5 501 4 dl dl NNP cord-006856-b1w25ob5 501 5 pod pod NNP cord-006856-b1w25ob5 501 6 1 1 CD cord-006856-b1w25ob5 501 7 ) ) -RRB- cord-006856-b1w25ob5 501 8 in in IN cord-006856-b1w25ob5 501 9 3 3 CD cord-006856-b1w25ob5 501 10 cases case NNS cord-006856-b1w25ob5 501 11 , , , cord-006856-b1w25ob5 501 12 all all DT cord-006856-b1w25ob5 501 13 patients patient NNS cord-006856-b1w25ob5 501 14 survived survive VBD cord-006856-b1w25ob5 501 15 . . . cord-006856-b1w25ob5 502 1 Conclusions conclusion NNS cord-006856-b1w25ob5 502 2 . . . cord-006856-b1w25ob5 503 1 Marginal marginal JJ cord-006856-b1w25ob5 503 2 livers liver NNS cord-006856-b1w25ob5 503 3 are be VBP cord-006856-b1w25ob5 503 4 eligible eligible JJ cord-006856-b1w25ob5 503 5 for for IN cord-006856-b1w25ob5 503 6 transplantation transplantation NN cord-006856-b1w25ob5 503 7 . . . cord-006856-b1w25ob5 504 1 Delayed delay VBN cord-006856-b1w25ob5 504 2 graft graft NN cord-006856-b1w25ob5 504 3 function function NN cord-006856-b1w25ob5 504 4 has have VBZ cord-006856-b1w25ob5 504 5 to to TO cord-006856-b1w25ob5 504 6 be be VB cord-006856-b1w25ob5 504 7 taken take VBN cord-006856-b1w25ob5 504 8 into into IN cord-006856-b1w25ob5 504 9 account account NN cord-006856-b1w25ob5 504 10 . . . cord-006856-b1w25ob5 505 1 Hospital hospital NN cord-006856-b1w25ob5 505 2 between between IN cord-006856-b1w25ob5 505 3 January January NNP cord-006856-b1w25ob5 505 4 1993 1993 CD cord-006856-b1w25ob5 505 5 and and CC cord-006856-b1w25ob5 505 6 December December NNP cord-006856-b1w25ob5 505 7 2003 2003 CD cord-006856-b1w25ob5 505 8 . . . cord-006856-b1w25ob5 506 1 We -PRON- PRP cord-006856-b1w25ob5 506 2 employed employ VBD cord-006856-b1w25ob5 506 3 the the DT cord-006856-b1w25ob5 506 4 local local JJ cord-006856-b1w25ob5 506 5 registry registry NN cord-006856-b1w25ob5 506 6 of of IN cord-006856-b1w25ob5 506 7 the the DT cord-006856-b1w25ob5 506 8 department department NN cord-006856-b1w25ob5 506 9 of of IN cord-006856-b1w25ob5 506 10 transplant transplant NN cord-006856-b1w25ob5 506 11 surgery surgery NN cord-006856-b1w25ob5 506 12 , , , cord-006856-b1w25ob5 506 13 where where WRB cord-006856-b1w25ob5 506 14 variables variable NNS cord-006856-b1w25ob5 506 15 of of IN cord-006856-b1w25ob5 506 16 all all DT cord-006856-b1w25ob5 506 17 patients patient NNS cord-006856-b1w25ob5 506 18 are be VBP cord-006856-b1w25ob5 506 19 routinely routinely RB cord-006856-b1w25ob5 506 20 and and CC cord-006856-b1w25ob5 506 21 prospectively prospectively RB cord-006856-b1w25ob5 506 22 recorded record VBN cord-006856-b1w25ob5 506 23 . . . cord-006856-b1w25ob5 507 1 Primary primary JJ cord-006856-b1w25ob5 507 2 outcome outcome NN cord-006856-b1w25ob5 507 3 was be VBD cord-006856-b1w25ob5 507 4 initial initial JJ cord-006856-b1w25ob5 507 5 graft graft NN cord-006856-b1w25ob5 507 6 function function NN cord-006856-b1w25ob5 507 7 , , , cord-006856-b1w25ob5 507 8 secondary secondary JJ cord-006856-b1w25ob5 507 9 outcome outcome NN cord-006856-b1w25ob5 507 10 was be VBD cord-006856-b1w25ob5 507 11 patient patient JJ cord-006856-b1w25ob5 507 12 survival survival NN cord-006856-b1w25ob5 507 13 . . . cord-006856-b1w25ob5 508 1 Results result NNS cord-006856-b1w25ob5 508 2 . . . cord-006856-b1w25ob5 509 1 Cumulative cumulative JJ cord-006856-b1w25ob5 509 2 number number NN cord-006856-b1w25ob5 509 3 of of IN cord-006856-b1w25ob5 509 4 marginal marginal JJ cord-006856-b1w25ob5 509 5 donor donor NN cord-006856-b1w25ob5 509 6 criteria criterion NNS cord-006856-b1w25ob5 509 7 was be VBD cord-006856-b1w25ob5 509 8 significantly significantly RB cord-006856-b1w25ob5 509 9 and and CC cord-006856-b1w25ob5 509 10 linearly linearly RB cord-006856-b1w25ob5 509 11 associated associate VBN cord-006856-b1w25ob5 509 12 with with IN cord-006856-b1w25ob5 509 13 an an DT cord-006856-b1w25ob5 509 14 increased increase VBN cord-006856-b1w25ob5 509 15 rate rate NN cord-006856-b1w25ob5 509 16 of of IN cord-006856-b1w25ob5 509 17 primary primary JJ cord-006856-b1w25ob5 509 18 dysfunction dysfunction NN cord-006856-b1w25ob5 509 19 ( ( -LRB- cord-006856-b1w25ob5 509 20 P p NN cord-006856-b1w25ob5 509 21 = = SYM cord-006856-b1w25ob5 509 22 0.005 0.005 CD cord-006856-b1w25ob5 509 23 ) ) -RRB- cord-006856-b1w25ob5 509 24 . . . cord-006856-b1w25ob5 510 1 In in IN cord-006856-b1w25ob5 510 2 patients patient NNS cord-006856-b1w25ob5 510 3 with with IN cord-006856-b1w25ob5 510 4 more more JJR cord-006856-b1w25ob5 510 5 than than IN cord-006856-b1w25ob5 510 6 three three CD cord-006856-b1w25ob5 510 7 cumulative cumulative JJ cord-006856-b1w25ob5 510 8 marginal marginal JJ cord-006856-b1w25ob5 510 9 donor donor NN cord-006856-b1w25ob5 510 10 criteria criterion NNS cord-006856-b1w25ob5 510 11 the the DT cord-006856-b1w25ob5 510 12 rate rate NN cord-006856-b1w25ob5 510 13 of of IN cord-006856-b1w25ob5 510 14 primary primary JJ cord-006856-b1w25ob5 510 15 dysfunction dysfunction NN cord-006856-b1w25ob5 510 16 was be VBD cord-006856-b1w25ob5 510 17 36 36 CD cord-006856-b1w25ob5 510 18 percent percent NN cord-006856-b1w25ob5 510 19 . . . cord-006856-b1w25ob5 511 1 Patient patient JJ cord-006856-b1w25ob5 511 2 survival survival NN cord-006856-b1w25ob5 511 3 was be VBD cord-006856-b1w25ob5 511 4 not not RB cord-006856-b1w25ob5 511 5 influenced influence VBN cord-006856-b1w25ob5 511 6 by by IN cord-006856-b1w25ob5 511 7 the the DT cord-006856-b1w25ob5 511 8 cumulative cumulative JJ cord-006856-b1w25ob5 511 9 number number NN cord-006856-b1w25ob5 511 10 of of IN cord-006856-b1w25ob5 511 11 donor donor NN cord-006856-b1w25ob5 511 12 criteria criterion NNS cord-006856-b1w25ob5 511 13 ( ( -LRB- cord-006856-b1w25ob5 511 14 log log NN cord-006856-b1w25ob5 511 15 - - HYPH cord-006856-b1w25ob5 511 16 Rank rank NN cord-006856-b1w25ob5 511 17 test test NN cord-006856-b1w25ob5 511 18 , , , cord-006856-b1w25ob5 511 19 P p NN cord-006856-b1w25ob5 511 20 = = SYM cord-006856-b1w25ob5 511 21 0.81 0.81 CD cord-006856-b1w25ob5 511 22 ) ) -RRB- cord-006856-b1w25ob5 511 23 . . . cord-006856-b1w25ob5 512 1 Independent independent JJ cord-006856-b1w25ob5 512 2 marginal marginal JJ cord-006856-b1w25ob5 512 3 donor donor NN cord-006856-b1w25ob5 512 4 criteria criterion NNS cord-006856-b1w25ob5 512 5 to to TO cord-006856-b1w25ob5 512 6 predict predict VB cord-006856-b1w25ob5 512 7 primary primary JJ cord-006856-b1w25ob5 512 8 dysfunction dysfunction NN cord-006856-b1w25ob5 512 9 were be VBD cord-006856-b1w25ob5 512 10 cold cold JJ cord-006856-b1w25ob5 512 11 ischemia ischemia NN cord-006856-b1w25ob5 512 12 time time NN cord-006856-b1w25ob5 512 13 of of IN cord-006856-b1w25ob5 512 14 > > XX cord-006856-b1w25ob5 512 15 10 10 CD cord-006856-b1w25ob5 512 16 hours hour NNS cord-006856-b1w25ob5 512 17 ( ( -LRB- cord-006856-b1w25ob5 512 18 OR or CC cord-006856-b1w25ob5 512 19 , , , cord-006856-b1w25ob5 512 20 0.56 0.56 CD cord-006856-b1w25ob5 512 21 ; ; : cord-006856-b1w25ob5 512 22 95 95 CD cord-006856-b1w25ob5 512 23 % % NN cord-006856-b1w25ob5 512 24 CI CI NNP cord-006856-b1w25ob5 512 25 , , , cord-006856-b1w25ob5 512 26 0.32 0.32 CD cord-006856-b1w25ob5 512 27 to to IN cord-006856-b1w25ob5 512 28 0.98 0.98 CD cord-006856-b1w25ob5 512 29 ) ) -RRB- cord-006856-b1w25ob5 512 30 and and CC cord-006856-b1w25ob5 512 31 donor donor NN cord-006856-b1w25ob5 512 32 peak peak NN cord-006856-b1w25ob5 512 33 serum serum NN cord-006856-b1w25ob5 512 34 sodiumof sodiumof NN cord-006856-b1w25ob5 512 35 > > XX cord-006856-b1w25ob5 513 1 155 155 CD cord-006856-b1w25ob5 513 2 mEq mEq NNS cord-006856-b1w25ob5 513 3 / / SYM cord-006856-b1w25ob5 513 4 l l NN cord-006856-b1w25ob5 513 5 ( ( -LRB- cord-006856-b1w25ob5 513 6 OR or CC cord-006856-b1w25ob5 513 7 , , , cord-006856-b1w25ob5 513 8 0.44 0.44 CD cord-006856-b1w25ob5 513 9 ; ; : cord-006856-b1w25ob5 513 10 95 95 CD cord-006856-b1w25ob5 513 11 % % NN cord-006856-b1w25ob5 513 12 CI CI NNP cord-006856-b1w25ob5 513 13 , , , cord-006856-b1w25ob5 513 14 0.26 0.26 CD cord-006856-b1w25ob5 513 15 to to IN cord-006856-b1w25ob5 513 16 0.77 0.77 CD cord-006856-b1w25ob5 513 17 ) ) -RRB- cord-006856-b1w25ob5 513 18 , , , cord-006856-b1w25ob5 513 19 as as IN cord-006856-b1w25ob5 513 20 assessed assess VBN cord-006856-b1w25ob5 513 21 in in IN cord-006856-b1w25ob5 513 22 a a DT cord-006856-b1w25ob5 513 23 multivariate multivariate JJ cord-006856-b1w25ob5 513 24 regression regression NN cord-006856-b1w25ob5 513 25 model model NN cord-006856-b1w25ob5 513 26 . . . cord-006856-b1w25ob5 514 1 Conclusions conclusion NNS cord-006856-b1w25ob5 514 2 . . . cord-006856-b1w25ob5 515 1 The the DT cord-006856-b1w25ob5 515 2 use use NN cord-006856-b1w25ob5 515 3 of of IN cord-006856-b1w25ob5 515 4 marginal marginal JJ cord-006856-b1w25ob5 515 5 liver liver NN cord-006856-b1w25ob5 515 6 donors donor NNS cord-006856-b1w25ob5 515 7 with with IN cord-006856-b1w25ob5 515 8 more more JJR cord-006856-b1w25ob5 515 9 than than IN cord-006856-b1w25ob5 515 10 three three CD cord-006856-b1w25ob5 515 11 marginal marginal JJ cord-006856-b1w25ob5 515 12 donor donor NN cord-006856-b1w25ob5 515 13 criteria criterion NNS cord-006856-b1w25ob5 515 14 shows show VBZ cord-006856-b1w25ob5 515 15 deleterious deleterious JJ cord-006856-b1w25ob5 515 16 effects effect NNS cord-006856-b1w25ob5 515 17 on on IN cord-006856-b1w25ob5 515 18 initial initial JJ cord-006856-b1w25ob5 515 19 graft graft NN cord-006856-b1w25ob5 515 20 function function NN cord-006856-b1w25ob5 515 21 . . . cord-006856-b1w25ob5 516 1 Noteworthy noteworthy JJ cord-006856-b1w25ob5 516 2 , , , cord-006856-b1w25ob5 516 3 patient patient JJ cord-006856-b1w25ob5 516 4 survival survival NN cord-006856-b1w25ob5 516 5 was be VBD cord-006856-b1w25ob5 516 6 not not RB cord-006856-b1w25ob5 516 7 associated associate VBN cord-006856-b1w25ob5 516 8 with with IN cord-006856-b1w25ob5 516 9 marginal marginal JJ cord-006856-b1w25ob5 516 10 donor donor NN cord-006856-b1w25ob5 516 11 criteria criterion NNS cord-006856-b1w25ob5 516 12 , , , cord-006856-b1w25ob5 516 13 which which WDT cord-006856-b1w25ob5 516 14 may may MD cord-006856-b1w25ob5 516 15 be be VB cord-006856-b1w25ob5 516 16 explained explain VBN cord-006856-b1w25ob5 516 17 by by IN cord-006856-b1w25ob5 516 18 early early JJ cord-006856-b1w25ob5 516 19 and and CC cord-006856-b1w25ob5 516 20 successful successful JJ cord-006856-b1w25ob5 516 21 retransplantation retransplantation NN cord-006856-b1w25ob5 516 22 of of IN cord-006856-b1w25ob5 516 23 liver liver NN cord-006856-b1w25ob5 516 24 recipients recipient NNS cord-006856-b1w25ob5 516 25 with with IN cord-006856-b1w25ob5 516 26 primary primary JJ cord-006856-b1w25ob5 516 27 nonfunction nonfunction NN cord-006856-b1w25ob5 516 28 . . . cord-006856-b1w25ob5 517 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 517 2 . . . cord-006856-b1w25ob5 518 1 Alle Alle NNP cord-006856-b1w25ob5 518 2 Transplantate Transplantate NNP cord-006856-b1w25ob5 518 3 zeigten zeigten XX cord-006856-b1w25ob5 518 4 eine eine FW cord-006856-b1w25ob5 518 5 gute gute NNP cord-006856-b1w25ob5 518 6 initiale initiale NNP cord-006856-b1w25ob5 518 7 Organfunktion Organfunktion NNP cord-006856-b1w25ob5 518 8 , , , cord-006856-b1w25ob5 518 9 der der NNP cord-006856-b1w25ob5 518 10 Transaminasenverlauf Transaminasenverlauf NNP cord-006856-b1w25ob5 518 11 und und IN cord-006856-b1w25ob5 518 12 das das NNP cord-006856-b1w25ob5 518 13 Gesamtbilirubin Gesamtbilirubin NNP cord-006856-b1w25ob5 518 14 , , , cord-006856-b1w25ob5 518 15 gemessen gemessen NNP cord-006856-b1w25ob5 518 16 am be VBP cord-006856-b1w25ob5 518 17 1 1 CD cord-006856-b1w25ob5 518 18 . . . cord-006856-b1w25ob5 519 1 postoperativen postoperativen NNP cord-006856-b1w25ob5 519 2 Tag Tag NNP cord-006856-b1w25ob5 519 3 , , , cord-006856-b1w25ob5 519 4 am be VBP cord-006856-b1w25ob5 519 5 7 7 CD cord-006856-b1w25ob5 519 6 . . . cord-006856-b1w25ob5 520 1 postoperativen postoperativen NNP cord-006856-b1w25ob5 520 2 Tag Tag NNP cord-006856-b1w25ob5 520 3 und und NNP cord-006856-b1w25ob5 520 4 bei bei NNP cord-006856-b1w25ob5 520 5 Entlassung Entlassung NNP cord-006856-b1w25ob5 520 6 ( ( -LRB- cord-006856-b1w25ob5 521 1 Mittelwerte Mittelwerte NNP cord-006856-b1w25ob5 521 2 mit mit NNP cord-006856-b1w25ob5 521 3 Standardabweichung Standardabweichung NNP cord-006856-b1w25ob5 521 4 ) ) -RRB- cord-006856-b1w25ob5 521 5 waren waren NNP cord-006856-b1w25ob5 521 6 wie wie NNP cord-006856-b1w25ob5 521 7 folgt folgt NNP cord-006856-b1w25ob5 521 8 : : : cord-006856-b1w25ob5 522 1 GOT get VBD cord-006856-b1w25ob5 522 2 1334 1334 CD cord-006856-b1w25ob5 522 3 U U NNP cord-006856-b1w25ob5 522 4 / / SYM cord-006856-b1w25ob5 522 5 l l NNP cord-006856-b1w25ob5 522 6 ( ( -LRB- cord-006856-b1w25ob5 522 7 ±848 ±848 NNP cord-006856-b1w25ob5 522 8 ) ) -RRB- cord-006856-b1w25ob5 522 9 , , . cord-006856-b1w25ob5 523 1 43 43 CD cord-006856-b1w25ob5 523 2 U U NNP cord-006856-b1w25ob5 523 3 / / SYM cord-006856-b1w25ob5 523 4 l l NN cord-006856-b1w25ob5 523 5 ( ( -LRB- cord-006856-b1w25ob5 523 6 ±13 ±13 NNP cord-006856-b1w25ob5 523 7 ) ) -RRB- cord-006856-b1w25ob5 523 8 , , , cord-006856-b1w25ob5 523 9 25 25 CD cord-006856-b1w25ob5 523 10 U U NNP cord-006856-b1w25ob5 523 11 / / SYM cord-006856-b1w25ob5 523 12 l l NN cord-006856-b1w25ob5 523 13 ( ( -LRB- cord-006856-b1w25ob5 523 14 ±9 ±9 NNP cord-006856-b1w25ob5 523 15 ) ) -RRB- cord-006856-b1w25ob5 523 16 ; ; : cord-006856-b1w25ob5 523 17 GPT GPT NNP cord-006856-b1w25ob5 523 18 877 877 CD cord-006856-b1w25ob5 523 19 U U NNP cord-006856-b1w25ob5 523 20 / / SYM cord-006856-b1w25ob5 523 21 l l NN cord-006856-b1w25ob5 523 22 ( ( -LRB- cord-006856-b1w25ob5 523 23 ±245 ±245 NNP cord-006856-b1w25ob5 523 24 ) ) -RRB- cord-006856-b1w25ob5 523 25 , , , cord-006856-b1w25ob5 523 26 420 420 CD cord-006856-b1w25ob5 523 27 U u NN cord-006856-b1w25ob5 523 28 / / SYM cord-006856-b1w25ob5 523 29 l l NN cord-006856-b1w25ob5 523 30 ( ( -LRB- cord-006856-b1w25ob5 523 31 ±649 ±649 NNP cord-006856-b1w25ob5 523 32 ) ) -RRB- cord-006856-b1w25ob5 523 33 , , , cord-006856-b1w25ob5 523 34 54 54 CD cord-006856-b1w25ob5 523 35 U U NNP cord-006856-b1w25ob5 523 36 / / SYM cord-006856-b1w25ob5 523 37 l l NN cord-006856-b1w25ob5 523 38 ( ( -LRB- cord-006856-b1w25ob5 523 39 ±40 ±40 NNP cord-006856-b1w25ob5 523 40 ) ) -RRB- cord-006856-b1w25ob5 523 41 ; ; : cord-006856-b1w25ob5 523 42 GGT GGT NNP cord-006856-b1w25ob5 523 43 118 118 CD cord-006856-b1w25ob5 523 44 U U NNP cord-006856-b1w25ob5 523 45 / / SYM cord-006856-b1w25ob5 523 46 l l NN cord-006856-b1w25ob5 523 47 ( ( -LRB- cord-006856-b1w25ob5 523 48 ±86 ±86 NNP cord-006856-b1w25ob5 523 49 ) ) -RRB- cord-006856-b1w25ob5 523 50 , , , cord-006856-b1w25ob5 523 51 355 355 CD cord-006856-b1w25ob5 523 52 U u NN cord-006856-b1w25ob5 523 53 / / SYM cord-006856-b1w25ob5 523 54 l l NN cord-006856-b1w25ob5 523 55 ( ( -LRB- cord-006856-b1w25ob5 523 56 ±232 ±232 NNP cord-006856-b1w25ob5 523 57 ) ) -RRB- cord-006856-b1w25ob5 523 58 , , , cord-006856-b1w25ob5 523 59 232 232 CD cord-006856-b1w25ob5 523 60 U u NN cord-006856-b1w25ob5 523 61 / / SYM cord-006856-b1w25ob5 523 62 l l NN cord-006856-b1w25ob5 523 63 ( ( -LRB- cord-006856-b1w25ob5 523 64 ±205 ±205 NNP cord-006856-b1w25ob5 523 65 ) ) -RRB- cord-006856-b1w25ob5 524 1 ; ; : cord-006856-b1w25ob5 524 2 Gesamtbilirubin Gesamtbilirubin NNP cord-006856-b1w25ob5 524 3 5,1 5,1 CD cord-006856-b1w25ob5 525 1 mg mg NNP cord-006856-b1w25ob5 525 2 / / SYM cord-006856-b1w25ob5 525 3 dl dl NNP cord-006856-b1w25ob5 525 4 ( ( -LRB- cord-006856-b1w25ob5 525 5 ±2,2 ±2,2 NNP cord-006856-b1w25ob5 525 6 ) ) -RRB- cord-006856-b1w25ob5 525 7 , , . cord-006856-b1w25ob5 526 1 3,5 3,5 CD cord-006856-b1w25ob5 526 2 mg mg NNP cord-006856-b1w25ob5 526 3 / / SYM cord-006856-b1w25ob5 526 4 dl dl NNP cord-006856-b1w25ob5 526 5 ( ( -LRB- cord-006856-b1w25ob5 526 6 ±2,5 ±2,5 NNP cord-006856-b1w25ob5 526 7 ) ) -RRB- cord-006856-b1w25ob5 526 8 , , , cord-006856-b1w25ob5 526 9 1,9 1,9 CD cord-006856-b1w25ob5 526 10 mg mg NNP cord-006856-b1w25ob5 526 11 / / SYM cord-006856-b1w25ob5 526 12 dl dl NNP cord-006856-b1w25ob5 526 13 ( ( -LRB- cord-006856-b1w25ob5 526 14 ±0,9 ±0,9 NNP cord-006856-b1w25ob5 526 15 ) ) -RRB- cord-006856-b1w25ob5 526 16 . . . cord-006856-b1w25ob5 527 1 Background background NN cord-006856-b1w25ob5 527 2 . . . cord-006856-b1w25ob5 528 1 MELD meld VB cord-006856-b1w25ob5 528 2 score score NN cord-006856-b1w25ob5 528 3 is be VBZ cord-006856-b1w25ob5 528 4 a a DT cord-006856-b1w25ob5 528 5 useful useful JJ cord-006856-b1w25ob5 528 6 tool tool NN cord-006856-b1w25ob5 528 7 in in IN cord-006856-b1w25ob5 528 8 predicting predict VBG cord-006856-b1w25ob5 528 9 mortality mortality NN cord-006856-b1w25ob5 528 10 in in IN cord-006856-b1w25ob5 528 11 patients patient NNS cord-006856-b1w25ob5 528 12 awaiting await VBG cord-006856-b1w25ob5 528 13 liver liver NN cord-006856-b1w25ob5 528 14 transplantation transplantation NN cord-006856-b1w25ob5 528 15 . . . cord-006856-b1w25ob5 529 1 Its -PRON- PRP$ cord-006856-b1w25ob5 529 2 capacity capacity NN cord-006856-b1w25ob5 529 3 to to TO cord-006856-b1w25ob5 529 4 predict predict VB cord-006856-b1w25ob5 529 5 patient patient JJ cord-006856-b1w25ob5 529 6 survival survival NN cord-006856-b1w25ob5 529 7 seems seem VBZ cord-006856-b1w25ob5 529 8 to to TO cord-006856-b1w25ob5 529 9 be be VB cord-006856-b1w25ob5 529 10 relatively relatively RB cord-006856-b1w25ob5 529 11 poor poor JJ cord-006856-b1w25ob5 529 12 and and CC cord-006856-b1w25ob5 529 13 is be VBZ cord-006856-b1w25ob5 529 14 still still RB cord-006856-b1w25ob5 529 15 discussed discuss VBN cord-006856-b1w25ob5 529 16 controversially controversially RB cord-006856-b1w25ob5 529 17 . . . cord-006856-b1w25ob5 530 1 The the DT cord-006856-b1w25ob5 530 2 purpose purpose NN cord-006856-b1w25ob5 530 3 of of IN cord-006856-b1w25ob5 530 4 the the DT cord-006856-b1w25ob5 530 5 study study NN cord-006856-b1w25ob5 530 6 was be VBD cord-006856-b1w25ob5 530 7 to to TO cord-006856-b1w25ob5 530 8 analyse analyse VB cord-006856-b1w25ob5 530 9 the the DT cord-006856-b1w25ob5 530 10 impact impact NN cord-006856-b1w25ob5 530 11 of of IN cord-006856-b1w25ob5 530 12 alterations alteration NNS cord-006856-b1w25ob5 530 13 of of IN cord-006856-b1w25ob5 530 14 the the DT cord-006856-b1w25ob5 530 15 MELD MELD NNP cord-006856-b1w25ob5 530 16 score score NN cord-006856-b1w25ob5 530 17 during during IN cord-006856-b1w25ob5 530 18 waiting wait VBG cord-006856-b1w25ob5 530 19 time time NN cord-006856-b1w25ob5 530 20 on on IN cord-006856-b1w25ob5 530 21 the the DT cord-006856-b1w25ob5 530 22 posttransplant posttransplant NNP cord-006856-b1w25ob5 530 23 survival survival NN cord-006856-b1w25ob5 530 24 rate rate NN cord-006856-b1w25ob5 530 25 . . . cord-006856-b1w25ob5 531 1 Additionally additionally RB cord-006856-b1w25ob5 531 2 , , , cord-006856-b1w25ob5 531 3 the the DT cord-006856-b1w25ob5 531 4 impact impact NN cord-006856-b1w25ob5 531 5 of of IN cord-006856-b1w25ob5 531 6 donor donor NN cord-006856-b1w25ob5 531 7 quality quality NN cord-006856-b1w25ob5 531 8 on on IN cord-006856-b1w25ob5 531 9 posttransplant posttransplant NN cord-006856-b1w25ob5 531 10 survival survival NN cord-006856-b1w25ob5 531 11 was be VBD cord-006856-b1w25ob5 531 12 investigated investigate VBN cord-006856-b1w25ob5 531 13 . . . cord-006856-b1w25ob5 532 1 Methods method NNS cord-006856-b1w25ob5 532 2 . . . cord-006856-b1w25ob5 533 1 242 242 CD cord-006856-b1w25ob5 533 2 adult adult NN cord-006856-b1w25ob5 533 3 patients patient NNS cord-006856-b1w25ob5 533 4 were be VBD cord-006856-b1w25ob5 533 5 transplanted transplant VBN cord-006856-b1w25ob5 533 6 between between IN cord-006856-b1w25ob5 533 7 1997 1997 CD cord-006856-b1w25ob5 533 8 and and CC cord-006856-b1w25ob5 533 9 2003 2003 CD cord-006856-b1w25ob5 533 10 because because IN cord-006856-b1w25ob5 533 11 of of IN cord-006856-b1w25ob5 533 12 end end NN cord-006856-b1w25ob5 533 13 stage stage NN cord-006856-b1w25ob5 533 14 liver liver NN cord-006856-b1w25ob5 533 15 disease disease NN cord-006856-b1w25ob5 533 16 without without IN cord-006856-b1w25ob5 533 17 malignancy malignancy NN cord-006856-b1w25ob5 533 18 . . . cord-006856-b1w25ob5 534 1 The the DT cord-006856-b1w25ob5 534 2 MELD MELD NNP cord-006856-b1w25ob5 534 3 scores score NNS cord-006856-b1w25ob5 534 4 at at IN cord-006856-b1w25ob5 534 5 time time NN cord-006856-b1w25ob5 534 6 of of IN cord-006856-b1w25ob5 534 7 listing list VBG cord-006856-b1w25ob5 534 8 ( ( -LRB- cord-006856-b1w25ob5 534 9 MELD meld VB cord-006856-b1w25ob5 534 10 ON on RP cord-006856-b1w25ob5 534 11 ) ) -RRB- cord-006856-b1w25ob5 534 12 and and CC cord-006856-b1w25ob5 534 13 of of IN cord-006856-b1w25ob5 534 14 transplantation transplantation NN cord-006856-b1w25ob5 534 15 ( ( -LRB- cord-006856-b1w25ob5 534 16 MELD MELD NNP cord-006856-b1w25ob5 534 17 TX TX NNP cord-006856-b1w25ob5 534 18 ) ) -RRB- cord-006856-b1w25ob5 534 19 were be VBD cord-006856-b1w25ob5 534 20 gathered gather VBN cord-006856-b1w25ob5 534 21 . . . cord-006856-b1w25ob5 535 1 Additionally additionally RB cord-006856-b1w25ob5 535 2 the the DT cord-006856-b1w25ob5 535 3 delta delta NN cord-006856-b1w25ob5 535 4 - - : cord-006856-b1w25ob5 535 5 MELD MELD NNP cord-006856-b1w25ob5 535 6 was be VBD cord-006856-b1w25ob5 535 7 calculated calculate VBN cord-006856-b1w25ob5 535 8 from from IN cord-006856-b1w25ob5 535 9 listing list VBG cord-006856-b1w25ob5 535 10 to to IN cord-006856-b1w25ob5 535 11 transplantation transplantation NN cord-006856-b1w25ob5 535 12 . . . cord-006856-b1w25ob5 536 1 Results result NNS cord-006856-b1w25ob5 536 2 . . . cord-006856-b1w25ob5 537 1 A a DT cord-006856-b1w25ob5 537 2 high high JJ cord-006856-b1w25ob5 537 3 MELD MELD NNP cord-006856-b1w25ob5 537 4 TX TX NNP cord-006856-b1w25ob5 537 5 showed show VBD cord-006856-b1w25ob5 537 6 only only RB cord-006856-b1w25ob5 537 7 a a DT cord-006856-b1w25ob5 537 8 trend trend NN cord-006856-b1w25ob5 537 9 to to IN cord-006856-b1w25ob5 537 10 poorer poor JJR cord-006856-b1w25ob5 537 11 survival survival NN cord-006856-b1w25ob5 537 12 . . . cord-006856-b1w25ob5 538 1 Patients patient NNS cord-006856-b1w25ob5 538 2 who who WP cord-006856-b1w25ob5 538 3 died die VBD cord-006856-b1w25ob5 538 4 within within IN cord-006856-b1w25ob5 538 5 the the DT cord-006856-b1w25ob5 538 6 1 1 CD cord-006856-b1w25ob5 538 7 st st NNP cord-006856-b1w25ob5 538 8 year year NN cord-006856-b1w25ob5 538 9 after after IN cord-006856-b1w25ob5 538 10 transplantation transplantation NN cord-006856-b1w25ob5 538 11 showed show VBD cord-006856-b1w25ob5 538 12 a a DT cord-006856-b1w25ob5 538 13 significant significant JJ cord-006856-b1w25ob5 538 14 increase increase NN cord-006856-b1w25ob5 538 15 in in IN cord-006856-b1w25ob5 538 16 the the DT cord-006856-b1w25ob5 538 17 MELD MELD NNP cord-006856-b1w25ob5 538 18 score score NN cord-006856-b1w25ob5 538 19 during during IN cord-006856-b1w25ob5 538 20 waiting wait VBG cord-006856-b1w25ob5 538 21 time time NN cord-006856-b1w25ob5 538 22 ( ( -LRB- cord-006856-b1w25ob5 538 23 P p NN cord-006856-b1w25ob5 538 24 < < XX cord-006856-b1w25ob5 538 25 0.01 0.01 CD cord-006856-b1w25ob5 538 26 ) ) -RRB- cord-006856-b1w25ob5 538 27 . . . cord-006856-b1w25ob5 539 1 Patients patient NNS cord-006856-b1w25ob5 539 2 with with IN cord-006856-b1w25ob5 539 3 a a DT cord-006856-b1w25ob5 539 4 delta delta NN cord-006856-b1w25ob5 539 5 - - : cord-006856-b1w25ob5 539 6 MELD meld VB cord-006856-b1w25ob5 539 7 higher high JJR cord-006856-b1w25ob5 539 8 than than IN cord-006856-b1w25ob5 539 9 4 4 CD cord-006856-b1w25ob5 539 10 during during IN cord-006856-b1w25ob5 539 11 waiting wait VBG cord-006856-b1w25ob5 539 12 time time NN cord-006856-b1w25ob5 539 13 had have VBD cord-006856-b1w25ob5 539 14 a a DT cord-006856-b1w25ob5 539 15 50 50 CD cord-006856-b1w25ob5 539 16 % % NN cord-006856-b1w25ob5 539 17 1-year 1-year CD cord-006856-b1w25ob5 539 18 mortality mortality NN cord-006856-b1w25ob5 539 19 after after IN cord-006856-b1w25ob5 539 20 transplantation transplantation NN cord-006856-b1w25ob5 539 21 , , , cord-006856-b1w25ob5 539 22 patients patient NNS cord-006856-b1w25ob5 539 23 with with IN cord-006856-b1w25ob5 539 24 a a DT cord-006856-b1w25ob5 539 25 MELD MELD NNP cord-006856-b1w25ob5 539 26 increase increase NN cord-006856-b1w25ob5 539 27 not not RB cord-006856-b1w25ob5 539 28 higher high JJR cord-006856-b1w25ob5 539 29 than than IN cord-006856-b1w25ob5 539 30 4 4 CD cord-006856-b1w25ob5 539 31 had have VBD cord-006856-b1w25ob5 539 32 only only RB cord-006856-b1w25ob5 539 33 a a DT cord-006856-b1w25ob5 539 34 23.1 23.1 CD cord-006856-b1w25ob5 539 35 % % NN cord-006856-b1w25ob5 539 36 1-year 1-year CD cord-006856-b1w25ob5 539 37 mortality mortality NN cord-006856-b1w25ob5 539 38 ( ( -LRB- cord-006856-b1w25ob5 539 39 P p NN cord-006856-b1w25ob5 539 40 < < XX cord-006856-b1w25ob5 539 41 0.01 0.01 CD cord-006856-b1w25ob5 539 42 ) ) -RRB- cord-006856-b1w25ob5 539 43 . . . cord-006856-b1w25ob5 540 1 Patients patient NNS cord-006856-b1w25ob5 540 2 with with IN cord-006856-b1w25ob5 540 3 a a DT cord-006856-b1w25ob5 540 4 MELD MELD NNP cord-006856-b1w25ob5 540 5 score score NN cord-006856-b1w25ob5 540 6 higher high JJR cord-006856-b1w25ob5 540 7 than than IN cord-006856-b1w25ob5 540 8 24 24 CD cord-006856-b1w25ob5 540 9 who who WP cord-006856-b1w25ob5 540 10 received receive VBD cord-006856-b1w25ob5 540 11 a a DT cord-006856-b1w25ob5 540 12 marginal marginal JJ cord-006856-b1w25ob5 540 13 graft graft NN cord-006856-b1w25ob5 540 14 showed show VBD cord-006856-b1w25ob5 540 15 a a DT cord-006856-b1w25ob5 540 16 trend trend NN cord-006856-b1w25ob5 540 17 to to IN cord-006856-b1w25ob5 540 18 poorer poor JJR cord-006856-b1w25ob5 540 19 posttransplant posttransplant NN cord-006856-b1w25ob5 540 20 survival survival NN cord-006856-b1w25ob5 540 21 . . . cord-006856-b1w25ob5 541 1 Conclusions conclusion NNS cord-006856-b1w25ob5 541 2 . . . cord-006856-b1w25ob5 542 1 Patients patient NNS cord-006856-b1w25ob5 542 2 with with IN cord-006856-b1w25ob5 542 3 a a DT cord-006856-b1w25ob5 542 4 substantial substantial JJ cord-006856-b1w25ob5 542 5 increase increase NN cord-006856-b1w25ob5 542 6 of of IN cord-006856-b1w25ob5 542 7 the the DT cord-006856-b1w25ob5 542 8 MELD MELD NNP cord-006856-b1w25ob5 542 9 score score NN cord-006856-b1w25ob5 542 10 during during IN cord-006856-b1w25ob5 542 11 waiting wait VBG cord-006856-b1w25ob5 542 12 time time NN cord-006856-b1w25ob5 542 13 had have VBD cord-006856-b1w25ob5 542 14 a a DT cord-006856-b1w25ob5 542 15 significantly significantly RB cord-006856-b1w25ob5 542 16 poorer poor JJR cord-006856-b1w25ob5 542 17 1year 1year CD cord-006856-b1w25ob5 542 18 posttransplant posttransplant NN cord-006856-b1w25ob5 542 19 survival survival NN cord-006856-b1w25ob5 542 20 . . . cord-006856-b1w25ob5 543 1 In in IN cord-006856-b1w25ob5 543 2 contrast contrast NN cord-006856-b1w25ob5 543 3 , , , cord-006856-b1w25ob5 543 4 the the DT cord-006856-b1w25ob5 543 5 MELD MELD NNP cord-006856-b1w25ob5 543 6 score score NN cord-006856-b1w25ob5 543 7 at at IN cord-006856-b1w25ob5 543 8 time time NN cord-006856-b1w25ob5 543 9 of of IN cord-006856-b1w25ob5 543 10 listing listing NN cord-006856-b1w25ob5 543 11 or or CC cord-006856-b1w25ob5 543 12 transplantation transplantation NN cord-006856-b1w25ob5 543 13 had have VBD cord-006856-b1w25ob5 543 14 no no DT cord-006856-b1w25ob5 543 15 impact impact NN cord-006856-b1w25ob5 543 16 on on IN cord-006856-b1w25ob5 543 17 the the DT cord-006856-b1w25ob5 543 18 posttransplant posttransplant NNP cord-006856-b1w25ob5 543 19 survival survival NN cord-006856-b1w25ob5 543 20 rate rate NN cord-006856-b1w25ob5 543 21 . . . cord-006856-b1w25ob5 544 1 The the DT cord-006856-b1w25ob5 544 2 use use NN cord-006856-b1w25ob5 544 3 of of IN cord-006856-b1w25ob5 544 4 marginal marginal JJ cord-006856-b1w25ob5 544 5 grafts graft NNS cord-006856-b1w25ob5 544 6 in in IN cord-006856-b1w25ob5 544 7 patients patient NNS cord-006856-b1w25ob5 544 8 with with IN cord-006856-b1w25ob5 544 9 a a DT cord-006856-b1w25ob5 544 10 higher high JJR cord-006856-b1w25ob5 544 11 MELD MELD NNP cord-006856-b1w25ob5 544 12 score score NN cord-006856-b1w25ob5 544 13 has have VBZ cord-006856-b1w25ob5 544 14 to to TO cord-006856-b1w25ob5 544 15 be be VB cord-006856-b1w25ob5 544 16 evaluated evaluate VBN cord-006856-b1w25ob5 544 17 carefully carefully RB cord-006856-b1w25ob5 544 18 . . . cord-006856-b1w25ob5 545 1 There there EX cord-006856-b1w25ob5 545 2 is be VBZ cord-006856-b1w25ob5 545 3 no no DT cord-006856-b1w25ob5 545 4 significant significant JJ cord-006856-b1w25ob5 545 5 difference difference NN cord-006856-b1w25ob5 545 6 of of IN cord-006856-b1w25ob5 545 7 serum serum NN cord-006856-b1w25ob5 545 8 sodium sodium NN cord-006856-b1w25ob5 545 9 levels level NNS cord-006856-b1w25ob5 545 10 in in IN cord-006856-b1w25ob5 545 11 LTX LTX NNP cord-006856-b1w25ob5 545 12 candidates candidate NNS cord-006856-b1w25ob5 545 13 with with IN cord-006856-b1w25ob5 545 14 or or CC cord-006856-b1w25ob5 545 15 without without IN cord-006856-b1w25ob5 545 16 ascites ascites NN cord-006856-b1w25ob5 545 17 crease crease NN cord-006856-b1w25ob5 545 18 in in IN cord-006856-b1w25ob5 545 19 serum serum NN cord-006856-b1w25ob5 545 20 creatinine creatinine NN cord-006856-b1w25ob5 545 21 is be VBZ cord-006856-b1w25ob5 545 22 a a DT cord-006856-b1w25ob5 545 23 late late JJ cord-006856-b1w25ob5 545 24 event event NN cord-006856-b1w25ob5 545 25 in in IN cord-006856-b1w25ob5 545 26 patients patient NNS cord-006856-b1w25ob5 545 27 with with IN cord-006856-b1w25ob5 545 28 ascites ascite NNS cord-006856-b1w25ob5 545 29 and and CC cord-006856-b1w25ob5 545 30 is be VBZ cord-006856-b1w25ob5 545 31 not not RB cord-006856-b1w25ob5 545 32 directly directly RB cord-006856-b1w25ob5 545 33 reflected reflect VBN cord-006856-b1w25ob5 545 34 within within IN cord-006856-b1w25ob5 545 35 the the DT cord-006856-b1w25ob5 545 36 MELD MELD NNP cord-006856-b1w25ob5 545 37 formula formula NN cord-006856-b1w25ob5 545 38 . . . cord-006856-b1w25ob5 546 1 For for IN cord-006856-b1w25ob5 546 2 this this DT cord-006856-b1w25ob5 546 3 purpose purpose NN cord-006856-b1w25ob5 546 4 we -PRON- PRP cord-006856-b1w25ob5 546 5 compared compare VBD cord-006856-b1w25ob5 546 6 patients patient NNS cord-006856-b1w25ob5 546 7 who who WP cord-006856-b1w25ob5 546 8 died die VBD cord-006856-b1w25ob5 546 9 on on IN cord-006856-b1w25ob5 546 10 the the DT cord-006856-b1w25ob5 546 11 waiting waiting NN cord-006856-b1w25ob5 546 12 list list NN cord-006856-b1w25ob5 546 13 with with IN cord-006856-b1w25ob5 546 14 patients patient NNS cord-006856-b1w25ob5 546 15 who who WP cord-006856-b1w25ob5 546 16 finally finally RB cord-006856-b1w25ob5 546 17 were be VBD cord-006856-b1w25ob5 546 18 transplanted transplant VBN cord-006856-b1w25ob5 546 19 . . . cord-006856-b1w25ob5 547 1 The the DT cord-006856-b1w25ob5 547 2 impact impact NN cord-006856-b1w25ob5 547 3 of of IN cord-006856-b1w25ob5 547 4 serum serum NN cord-006856-b1w25ob5 547 5 sodium sodium NN cord-006856-b1w25ob5 547 6 and and CC cord-006856-b1w25ob5 547 7 ascites ascites NN cord-006856-b1w25ob5 547 8 on on IN cord-006856-b1w25ob5 547 9 death death NN cord-006856-b1w25ob5 547 10 on on IN cord-006856-b1w25ob5 547 11 the the DT cord-006856-b1w25ob5 547 12 waiting waiting NN cord-006856-b1w25ob5 547 13 list list NN cord-006856-b1w25ob5 547 14 was be VBD cord-006856-b1w25ob5 547 15 evaluated evaluate VBN cord-006856-b1w25ob5 547 16 . . . cord-006856-b1w25ob5 548 1 Methods method NNS cord-006856-b1w25ob5 548 2 . . . cord-006856-b1w25ob5 549 1 From from IN cord-006856-b1w25ob5 549 2 1997 1997 CD cord-006856-b1w25ob5 549 3 to to IN cord-006856-b1w25ob5 549 4 2005 2005 CD cord-006856-b1w25ob5 549 5 , , , cord-006856-b1w25ob5 549 6 621 621 CD cord-006856-b1w25ob5 549 7 adult adult NN cord-006856-b1w25ob5 549 8 patients patient NNS cord-006856-b1w25ob5 549 9 with with IN cord-006856-b1w25ob5 549 10 end end NN cord-006856-b1w25ob5 549 11 - - HYPH cord-006856-b1w25ob5 549 12 stage stage NN cord-006856-b1w25ob5 549 13 liver liver NN cord-006856-b1w25ob5 549 14 disease disease NN cord-006856-b1w25ob5 549 15 were be VBD cord-006856-b1w25ob5 549 16 listed list VBN cord-006856-b1w25ob5 549 17 for for IN cord-006856-b1w25ob5 549 18 orthotopic orthotopic JJ cord-006856-b1w25ob5 549 19 liver liver NN cord-006856-b1w25ob5 549 20 transplantation transplantation NN cord-006856-b1w25ob5 549 21 ( ( -LRB- cord-006856-b1w25ob5 549 22 OLT OLT NNP cord-006856-b1w25ob5 549 23 ) ) -RRB- cord-006856-b1w25ob5 549 24 . . . cord-006856-b1w25ob5 550 1 Only only RB cord-006856-b1w25ob5 550 2 patients patient NNS cord-006856-b1w25ob5 550 3 without without IN cord-006856-b1w25ob5 550 4 hepatoma hepatoma NNP cord-006856-b1w25ob5 550 5 who who WP cord-006856-b1w25ob5 550 6 died die VBD cord-006856-b1w25ob5 550 7 on on IN cord-006856-b1w25ob5 550 8 the the DT cord-006856-b1w25ob5 550 9 waiting waiting NN cord-006856-b1w25ob5 550 10 list list NN cord-006856-b1w25ob5 550 11 ( ( -LRB- cord-006856-b1w25ob5 550 12 123 123 CD cord-006856-b1w25ob5 550 13 patients patient NNS cord-006856-b1w25ob5 550 14 ) ) -RRB- cord-006856-b1w25ob5 550 15 or or CC cord-006856-b1w25ob5 550 16 were be VBD cord-006856-b1w25ob5 550 17 finally finally RB cord-006856-b1w25ob5 550 18 transplanted transplant VBN cord-006856-b1w25ob5 550 19 ( ( -LRB- cord-006856-b1w25ob5 550 20 300 300 CD cord-006856-b1w25ob5 550 21 patients patient NNS cord-006856-b1w25ob5 550 22 ) ) -RRB- cord-006856-b1w25ob5 550 23 were be VBD cord-006856-b1w25ob5 550 24 evaluated evaluate VBN cord-006856-b1w25ob5 550 25 . . . cord-006856-b1w25ob5 551 1 In in IN cord-006856-b1w25ob5 551 2 addition addition NN cord-006856-b1w25ob5 551 3 to to IN cord-006856-b1w25ob5 551 4 the the DT cord-006856-b1w25ob5 551 5 MELD MELD NNP cord-006856-b1w25ob5 551 6 score score NN cord-006856-b1w25ob5 551 7 , , , cord-006856-b1w25ob5 551 8 the the DT cord-006856-b1w25ob5 551 9 serum serum NN cord-006856-b1w25ob5 551 10 sodium sodium NN cord-006856-b1w25ob5 551 11 and and CC cord-006856-b1w25ob5 551 12 the the DT cord-006856-b1w25ob5 551 13 ascites ascites NN cord-006856-b1w25ob5 551 14 were be VBD cord-006856-b1w25ob5 551 15 investigated investigate VBN cord-006856-b1w25ob5 551 16 at at IN cord-006856-b1w25ob5 551 17 time time NN cord-006856-b1w25ob5 551 18 of of IN cord-006856-b1w25ob5 551 19 listing listing NN cord-006856-b1w25ob5 551 20 and and CC cord-006856-b1w25ob5 551 21 of of IN cord-006856-b1w25ob5 551 22 coming come VBG cord-006856-b1w25ob5 551 23 off off IN cord-006856-b1w25ob5 551 24 the the DT cord-006856-b1w25ob5 551 25 list list NN cord-006856-b1w25ob5 551 26 ( ( -LRB- cord-006856-b1w25ob5 551 27 transplantation transplantation NN cord-006856-b1w25ob5 551 28 or or CC cord-006856-b1w25ob5 551 29 death death NN cord-006856-b1w25ob5 551 30 ) ) -RRB- cord-006856-b1w25ob5 551 31 . . . cord-006856-b1w25ob5 552 1 Results result NNS cord-006856-b1w25ob5 552 2 . . . cord-006856-b1w25ob5 553 1 Transplanted transplanted JJ cord-006856-b1w25ob5 553 2 patients patient NNS cord-006856-b1w25ob5 553 3 had have VBD cord-006856-b1w25ob5 553 4 a a DT cord-006856-b1w25ob5 553 5 significantly significantly RB cord-006856-b1w25ob5 553 6 lower low JJR cord-006856-b1w25ob5 553 7 MELD meld VB cord-006856-b1w25ob5 553 8 ON on RP cord-006856-b1w25ob5 554 1 ( ( -LRB- cord-006856-b1w25ob5 554 2 P p NN cord-006856-b1w25ob5 554 3 < < XX cord-006856-b1w25ob5 554 4 0.01 0.01 CD cord-006856-b1w25ob5 554 5 ) ) -RRB- cord-006856-b1w25ob5 554 6 than than IN cord-006856-b1w25ob5 554 7 the the DT cord-006856-b1w25ob5 554 8 patients patient NNS cord-006856-b1w25ob5 554 9 who who WP cord-006856-b1w25ob5 554 10 died die VBD cord-006856-b1w25ob5 554 11 while while IN cord-006856-b1w25ob5 554 12 on on IN cord-006856-b1w25ob5 554 13 the the DT cord-006856-b1w25ob5 554 14 waiting waiting NN cord-006856-b1w25ob5 554 15 list list NN cord-006856-b1w25ob5 554 16 . . . cord-006856-b1w25ob5 555 1 Patients patient NNS cord-006856-b1w25ob5 555 2 who who WP cord-006856-b1w25ob5 555 3 died die VBD cord-006856-b1w25ob5 555 4 while while IN cord-006856-b1w25ob5 555 5 on on IN cord-006856-b1w25ob5 555 6 the the DT cord-006856-b1w25ob5 555 7 waiting waiting NN cord-006856-b1w25ob5 555 8 list list NN cord-006856-b1w25ob5 555 9 had have VBD cord-006856-b1w25ob5 555 10 a a DT cord-006856-b1w25ob5 555 11 significant significant JJ cord-006856-b1w25ob5 555 12 increase increase NN cord-006856-b1w25ob5 555 13 in in IN cord-006856-b1w25ob5 555 14 the the DT cord-006856-b1w25ob5 555 15 MELD MELD NNP cord-006856-b1w25ob5 555 16 score score NN cord-006856-b1w25ob5 555 17 during during IN cord-006856-b1w25ob5 555 18 waiting wait VBG cord-006856-b1w25ob5 555 19 time time NN cord-006856-b1w25ob5 555 20 ( ( -LRB- cord-006856-b1w25ob5 555 21 P p NN cord-006856-b1w25ob5 555 22 < < XX cord-006856-b1w25ob5 555 23 0.01 0.01 CD cord-006856-b1w25ob5 555 24 ) ) -RRB- cord-006856-b1w25ob5 555 25 . . . cord-006856-b1w25ob5 556 1 Patients patient NNS cord-006856-b1w25ob5 556 2 who who WP cord-006856-b1w25ob5 556 3 underwent undergo VBD cord-006856-b1w25ob5 556 4 transplantation transplantation NN cord-006856-b1w25ob5 556 5 showed show VBD cord-006856-b1w25ob5 556 6 a a DT cord-006856-b1w25ob5 556 7 stable stable JJ cord-006856-b1w25ob5 556 8 MELD meld NN cord-006856-b1w25ob5 556 9 score score NN cord-006856-b1w25ob5 556 10 during during IN cord-006856-b1w25ob5 556 11 their -PRON- PRP$ cord-006856-b1w25ob5 556 12 waiting wait VBG cord-006856-b1w25ob5 556 13 time time NN cord-006856-b1w25ob5 556 14 . . . cord-006856-b1w25ob5 557 1 Refractory refractory JJ cord-006856-b1w25ob5 557 2 ascites ascites NN cord-006856-b1w25ob5 557 3 and and CC cord-006856-b1w25ob5 557 4 spontaneous spontaneous JJ cord-006856-b1w25ob5 557 5 bacterial bacterial JJ cord-006856-b1w25ob5 557 6 infection infection NN cord-006856-b1w25ob5 557 7 were be VBD cord-006856-b1w25ob5 557 8 evaluated evaluate VBN cord-006856-b1w25ob5 557 9 as as IN cord-006856-b1w25ob5 557 10 independent independent JJ cord-006856-b1w25ob5 557 11 risk risk NN cord-006856-b1w25ob5 557 12 factors factor NNS cord-006856-b1w25ob5 557 13 for for IN cord-006856-b1w25ob5 557 14 death death NN cord-006856-b1w25ob5 557 15 on on IN cord-006856-b1w25ob5 557 16 the the DT cord-006856-b1w25ob5 557 17 waiting waiting NN cord-006856-b1w25ob5 557 18 list list NN cord-006856-b1w25ob5 557 19 as as RB cord-006856-b1w25ob5 557 20 well well RB cord-006856-b1w25ob5 557 21 as as IN cord-006856-b1w25ob5 557 22 the the DT cord-006856-b1w25ob5 557 23 MELD MELD NNP cord-006856-b1w25ob5 557 24 ON on RP cord-006856-b1w25ob5 557 25 . . . cord-006856-b1w25ob5 558 1 47.2 47.2 CD cord-006856-b1w25ob5 558 2 % % NN cord-006856-b1w25ob5 558 3 of of IN cord-006856-b1w25ob5 558 4 the the DT cord-006856-b1w25ob5 558 5 patients patient NNS cord-006856-b1w25ob5 558 6 ( ( -LRB- cord-006856-b1w25ob5 558 7 58 58 CD cord-006856-b1w25ob5 558 8 of of IN cord-006856-b1w25ob5 558 9 123 123 CD cord-006856-b1w25ob5 558 10 patients patient NNS cord-006856-b1w25ob5 558 11 ) ) -RRB- cord-006856-b1w25ob5 558 12 who who WP cord-006856-b1w25ob5 558 13 died die VBD cord-006856-b1w25ob5 558 14 on on IN cord-006856-b1w25ob5 558 15 the the DT cord-006856-b1w25ob5 558 16 waiting waiting NN cord-006856-b1w25ob5 558 17 list list NN cord-006856-b1w25ob5 558 18 were be VBD cord-006856-b1w25ob5 558 19 suffering suffer VBG cord-006856-b1w25ob5 558 20 from from IN cord-006856-b1w25ob5 558 21 ascites ascites NN cord-006856-b1w25ob5 558 22 , , , cord-006856-b1w25ob5 558 23 in in IN cord-006856-b1w25ob5 558 24 contrast contrast NN cord-006856-b1w25ob5 558 25 to to IN cord-006856-b1w25ob5 558 26 only only RB cord-006856-b1w25ob5 558 27 28.7 28.7 CD cord-006856-b1w25ob5 558 28 % % NN cord-006856-b1w25ob5 558 29 of of IN cord-006856-b1w25ob5 558 30 the the DT cord-006856-b1w25ob5 558 31 transplanted transplanted JJ cord-006856-b1w25ob5 558 32 patients patient NNS cord-006856-b1w25ob5 558 33 ( ( -LRB- cord-006856-b1w25ob5 558 34 86 86 CD cord-006856-b1w25ob5 558 35 of of IN cord-006856-b1w25ob5 558 36 300 300 CD cord-006856-b1w25ob5 558 37 patients patient NNS cord-006856-b1w25ob5 558 38 ) ) -RRB- cord-006856-b1w25ob5 558 39 . . . cord-006856-b1w25ob5 559 1 There there EX cord-006856-b1w25ob5 559 2 was be VBD cord-006856-b1w25ob5 559 3 no no DT cord-006856-b1w25ob5 559 4 significant significant JJ cord-006856-b1w25ob5 559 5 difference difference NN cord-006856-b1w25ob5 559 6 in in IN cord-006856-b1w25ob5 559 7 the the DT cord-006856-b1w25ob5 559 8 mean mean NN cord-006856-b1w25ob5 559 9 MELD meld VB cord-006856-b1w25ob5 559 10 ON on RP cord-006856-b1w25ob5 559 11 between between IN cord-006856-b1w25ob5 559 12 the the DT cord-006856-b1w25ob5 559 13 patients patient NNS cord-006856-b1w25ob5 559 14 who who WP cord-006856-b1w25ob5 559 15 were be VBD cord-006856-b1w25ob5 559 16 suffering suffer VBG cord-006856-b1w25ob5 559 17 from from IN cord-006856-b1w25ob5 559 18 ascites ascites NN cord-006856-b1w25ob5 559 19 and and CC cord-006856-b1w25ob5 559 20 those those DT cord-006856-b1w25ob5 559 21 who who WP cord-006856-b1w25ob5 559 22 were be VBD cord-006856-b1w25ob5 559 23 not not RB cord-006856-b1w25ob5 559 24 ( ( -LRB- cord-006856-b1w25ob5 559 25 P p NN cord-006856-b1w25ob5 559 26 = = SYM cord-006856-b1w25ob5 559 27 0.72 0.72 CD cord-006856-b1w25ob5 559 28 ) ) -RRB- cord-006856-b1w25ob5 559 29 . . . cord-006856-b1w25ob5 560 1 Nor nor CC cord-006856-b1w25ob5 560 2 was be VBD cord-006856-b1w25ob5 560 3 any any DT cord-006856-b1w25ob5 560 4 significant significant JJ cord-006856-b1w25ob5 560 5 difference difference NN cord-006856-b1w25ob5 560 6 found find VBN cord-006856-b1w25ob5 560 7 in in IN cord-006856-b1w25ob5 560 8 the the DT cord-006856-b1w25ob5 560 9 MELD MELD NNP cord-006856-b1w25ob5 560 10 OFF off RP cord-006856-b1w25ob5 561 1 ( ( -LRB- cord-006856-b1w25ob5 561 2 P p NN cord-006856-b1w25ob5 561 3 = = SYM cord-006856-b1w25ob5 561 4 0.77 0.77 CD cord-006856-b1w25ob5 561 5 ) ) -RRB- cord-006856-b1w25ob5 561 6 . . . cord-006856-b1w25ob5 562 1 The the DT cord-006856-b1w25ob5 562 2 serum serum NN cord-006856-b1w25ob5 562 3 sodium sodium NN cord-006856-b1w25ob5 562 4 of of IN cord-006856-b1w25ob5 562 5 patients patient NNS cord-006856-b1w25ob5 562 6 suffering suffer VBG cord-006856-b1w25ob5 562 7 from from IN cord-006856-b1w25ob5 562 8 ascites ascites NN cord-006856-b1w25ob5 562 9 showed show VBD cord-006856-b1w25ob5 562 10 no no DT cord-006856-b1w25ob5 562 11 significant significant JJ cord-006856-b1w25ob5 562 12 difference difference NN cord-006856-b1w25ob5 562 13 to to IN cord-006856-b1w25ob5 562 14 those those DT cord-006856-b1w25ob5 562 15 who who WP cord-006856-b1w25ob5 562 16 showed show VBD cord-006856-b1w25ob5 562 17 no no DT cord-006856-b1w25ob5 562 18 signs sign NNS cord-006856-b1w25ob5 562 19 of of IN cord-006856-b1w25ob5 562 20 ascites ascite NNS cord-006856-b1w25ob5 562 21 . . . cord-006856-b1w25ob5 563 1 Conclusions conclusion NNS cord-006856-b1w25ob5 563 2 . . . cord-006856-b1w25ob5 564 1 Ascites Ascites NNP cord-006856-b1w25ob5 564 2 was be VBD cord-006856-b1w25ob5 564 3 evaluated evaluate VBN cord-006856-b1w25ob5 564 4 as as IN cord-006856-b1w25ob5 564 5 independent independent JJ cord-006856-b1w25ob5 564 6 risk risk NN cord-006856-b1w25ob5 564 7 factor factor NN cord-006856-b1w25ob5 564 8 for for IN cord-006856-b1w25ob5 564 9 death death NN cord-006856-b1w25ob5 564 10 on on IN cord-006856-b1w25ob5 564 11 the the DT cord-006856-b1w25ob5 564 12 waiting waiting NN cord-006856-b1w25ob5 564 13 list list NN cord-006856-b1w25ob5 564 14 . . . cord-006856-b1w25ob5 565 1 No no DT cord-006856-b1w25ob5 565 2 significant significant JJ cord-006856-b1w25ob5 565 3 difference difference NN cord-006856-b1w25ob5 565 4 in in IN cord-006856-b1w25ob5 565 5 the the DT cord-006856-b1w25ob5 565 6 serum serum NN cord-006856-b1w25ob5 565 7 sodium sodium NN cord-006856-b1w25ob5 565 8 levels level NNS cord-006856-b1w25ob5 565 9 were be VBD cord-006856-b1w25ob5 565 10 found find VBN cord-006856-b1w25ob5 565 11 between between IN cord-006856-b1w25ob5 565 12 patients patient NNS cord-006856-b1w25ob5 565 13 suffering suffer VBG cord-006856-b1w25ob5 565 14 from from IN cord-006856-b1w25ob5 565 15 ascites ascites NN cord-006856-b1w25ob5 565 16 or or CC cord-006856-b1w25ob5 565 17 not not RB cord-006856-b1w25ob5 565 18 . . . cord-006856-b1w25ob5 566 1 Therefore therefore RB cord-006856-b1w25ob5 566 2 complications complication NNS cord-006856-b1w25ob5 566 3 of of IN cord-006856-b1w25ob5 566 4 portal portal JJ cord-006856-b1w25ob5 566 5 hypertension hypertension NN cord-006856-b1w25ob5 566 6 should should MD cord-006856-b1w25ob5 566 7 be be VB cord-006856-b1w25ob5 566 8 treated treat VBN cord-006856-b1w25ob5 566 9 adequately adequately RB cord-006856-b1w25ob5 566 10 and and CC cord-006856-b1w25ob5 566 11 rigorously rigorously RB cord-006856-b1w25ob5 566 12 , , , cord-006856-b1w25ob5 566 13 especially especially RB cord-006856-b1w25ob5 566 14 in in IN cord-006856-b1w25ob5 566 15 patients patient NNS cord-006856-b1w25ob5 566 16 with with IN cord-006856-b1w25ob5 566 17 lower low JJR cord-006856-b1w25ob5 566 18 MELD MELD NNP cord-006856-b1w25ob5 566 19 scores score NNS cord-006856-b1w25ob5 566 20 . . . cord-006856-b1w25ob5 567 1 Renal renal JJ cord-006856-b1w25ob5 567 2 failure failure NN cord-006856-b1w25ob5 567 3 is be VBZ cord-006856-b1w25ob5 567 4 an an DT cord-006856-b1w25ob5 567 5 established establish VBN cord-006856-b1w25ob5 567 6 risk risk NN cord-006856-b1w25ob5 567 7 factor factor NN cord-006856-b1w25ob5 567 8 for for IN cord-006856-b1w25ob5 567 9 impaired impaired JJ cord-006856-b1w25ob5 567 10 patient patient NN cord-006856-b1w25ob5 567 11 outcome outcome NN cord-006856-b1w25ob5 567 12 after after IN cord-006856-b1w25ob5 567 13 orthotopic orthotopic JJ cord-006856-b1w25ob5 567 14 liver liver NN cord-006856-b1w25ob5 567 15 transplantation transplantation NN cord-006856-b1w25ob5 567 16 ( ( -LRB- cord-006856-b1w25ob5 567 17 OLT OLT NNP cord-006856-b1w25ob5 567 18 ) ) -RRB- cord-006856-b1w25ob5 567 19 . . . cord-006856-b1w25ob5 568 1 As as IN cord-006856-b1w25ob5 568 2 the the DT cord-006856-b1w25ob5 568 3 endothelin endothelin NNP cord-006856-b1w25ob5 568 4 pathway pathway NN cord-006856-b1w25ob5 568 5 is be VBZ cord-006856-b1w25ob5 568 6 known know VBN cord-006856-b1w25ob5 568 7 to to TO cord-006856-b1w25ob5 568 8 be be VB cord-006856-b1w25ob5 568 9 involved involve VBN cord-006856-b1w25ob5 568 10 in in IN cord-006856-b1w25ob5 568 11 the the DT cord-006856-b1w25ob5 568 12 development development NN cord-006856-b1w25ob5 568 13 of of IN cord-006856-b1w25ob5 568 14 acute acute JJ cord-006856-b1w25ob5 568 15 renal renal JJ cord-006856-b1w25ob5 568 16 failure failure NN cord-006856-b1w25ob5 568 17 ( ( -LRB- cord-006856-b1w25ob5 568 18 ARF ARF NNP cord-006856-b1w25ob5 568 19 ) ) -RRB- cord-006856-b1w25ob5 568 20 , , , cord-006856-b1w25ob5 568 21 we -PRON- PRP cord-006856-b1w25ob5 568 22 designed design VBD cord-006856-b1w25ob5 568 23 a a DT cord-006856-b1w25ob5 568 24 study study NN cord-006856-b1w25ob5 568 25 to to TO cord-006856-b1w25ob5 568 26 clarify clarify VB cord-006856-b1w25ob5 568 27 its -PRON- PRP$ cord-006856-b1w25ob5 568 28 role role NN cord-006856-b1w25ob5 568 29 in in IN cord-006856-b1w25ob5 568 30 ARF ARF NNP cord-006856-b1w25ob5 568 31 following follow VBG cord-006856-b1w25ob5 568 32 OLT OLT NNP cord-006856-b1w25ob5 568 33 . . . cord-006856-b1w25ob5 569 1 20 20 CD cord-006856-b1w25ob5 569 2 consecutive consecutive JJ cord-006856-b1w25ob5 569 3 patients patient NNS cord-006856-b1w25ob5 569 4 with with IN cord-006856-b1w25ob5 569 5 intact intact JJ cord-006856-b1w25ob5 569 6 kidney kidney NN cord-006856-b1w25ob5 569 7 function function NN cord-006856-b1w25ob5 569 8 scheduled schedule VBN cord-006856-b1w25ob5 569 9 for for IN cord-006856-b1w25ob5 569 10 their -PRON- PRP$ cord-006856-b1w25ob5 569 11 first first JJ cord-006856-b1w25ob5 569 12 OLT OLT NNP cord-006856-b1w25ob5 569 13 were be VBD cord-006856-b1w25ob5 569 14 prospectively prospectively RB cord-006856-b1w25ob5 569 15 studied study VBN cord-006856-b1w25ob5 569 16 . . . cord-006856-b1w25ob5 570 1 Plasma plasma NN cord-006856-b1w25ob5 570 2 big big JJ cord-006856-b1w25ob5 570 3 endothelin-1 endothelin-1 NNP cord-006856-b1w25ob5 570 4 ( ( -LRB- cord-006856-b1w25ob5 570 5 ET-1 ET-1 NNP cord-006856-b1w25ob5 570 6 ) ) -RRB- cord-006856-b1w25ob5 570 7 levels level NNS cord-006856-b1w25ob5 570 8 were be VBD cord-006856-b1w25ob5 570 9 measured measure VBN cord-006856-b1w25ob5 570 10 before before IN cord-006856-b1w25ob5 570 11 surgery surgery NN cord-006856-b1w25ob5 570 12 , , , cord-006856-b1w25ob5 570 13 after after IN cord-006856-b1w25ob5 570 14 graft graft NN cord-006856-b1w25ob5 570 15 reperfusion reperfusion NN cord-006856-b1w25ob5 570 16 , , , cord-006856-b1w25ob5 570 17 and and CC cord-006856-b1w25ob5 570 18 on on IN cord-006856-b1w25ob5 570 19 the the DT cord-006856-b1w25ob5 570 20 first first JJ cord-006856-b1w25ob5 570 21 and and CC cord-006856-b1w25ob5 570 22 second second JJ cord-006856-b1w25ob5 570 23 postoperative postoperative JJ cord-006856-b1w25ob5 570 24 days day NNS cord-006856-b1w25ob5 570 25 . . . cord-006856-b1w25ob5 571 1 According accord VBG cord-006856-b1w25ob5 571 2 to to IN cord-006856-b1w25ob5 571 3 postoperative postoperative JJ cord-006856-b1w25ob5 571 4 GFR GFR NNP cord-006856-b1w25ob5 571 5 , , , cord-006856-b1w25ob5 571 6 patients patient NNS cord-006856-b1w25ob5 571 7 were be VBD cord-006856-b1w25ob5 571 8 assigned assign VBN cord-006856-b1w25ob5 571 9 to to IN cord-006856-b1w25ob5 571 10 the the DT cord-006856-b1w25ob5 571 11 acute acute JJ cord-006856-b1w25ob5 571 12 renal renal JJ cord-006856-b1w25ob5 571 13 dysfunction dysfunction NN cord-006856-b1w25ob5 571 14 group group NN cord-006856-b1w25ob5 571 15 ( ( -LRB- cord-006856-b1w25ob5 571 16 ARDF ARDF NNP cord-006856-b1w25ob5 571 17 ) ) -RRB- cord-006856-b1w25ob5 571 18 and and CC cord-006856-b1w25ob5 571 19 the the DT cord-006856-b1w25ob5 571 20 non non JJ cord-006856-b1w25ob5 571 21 - - JJ cord-006856-b1w25ob5 571 22 ARDF ardf JJ cord-006856-b1w25ob5 571 23 group group NN cord-006856-b1w25ob5 571 24 . . . cord-006856-b1w25ob5 572 1 Each each DT cord-006856-b1w25ob5 572 2 patient patient NN cord-006856-b1w25ob5 572 3 's 's POS cord-006856-b1w25ob5 572 4 GFR GFR NNP cord-006856-b1w25ob5 572 5 was be VBD cord-006856-b1w25ob5 572 6 estimated estimate VBN cord-006856-b1w25ob5 572 7 according accord VBG cord-006856-b1w25ob5 572 8 to to IN cord-006856-b1w25ob5 572 9 the the DT cord-006856-b1w25ob5 572 10 four four CD cord-006856-b1w25ob5 572 11 variable variable JJ cord-006856-b1w25ob5 572 12 formula formula NN cord-006856-b1w25ob5 572 13 used use VBN cord-006856-b1w25ob5 572 14 in in IN cord-006856-b1w25ob5 572 15 the the DT cord-006856-b1w25ob5 572 16 Modification Modification NNP cord-006856-b1w25ob5 572 17 of of IN cord-006856-b1w25ob5 572 18 Diet Diet NNP cord-006856-b1w25ob5 572 19 in in IN cord-006856-b1w25ob5 572 20 Renal Renal NNP cord-006856-b1w25ob5 572 21 Disease Disease NNP cord-006856-b1w25ob5 572 22 before before IN cord-006856-b1w25ob5 572 23 surgery surgery NN cord-006856-b1w25ob5 572 24 , , , cord-006856-b1w25ob5 572 25 daily daily RB cord-006856-b1w25ob5 572 26 within within IN cord-006856-b1w25ob5 572 27 the the DT cord-006856-b1w25ob5 572 28 first first JJ cord-006856-b1w25ob5 572 29 postoperative postoperative JJ cord-006856-b1w25ob5 572 30 week week NN cord-006856-b1w25ob5 572 31 , , , cord-006856-b1w25ob5 572 32 and and CC cord-006856-b1w25ob5 572 33 at at IN cord-006856-b1w25ob5 572 34 1 1 CD cord-006856-b1w25ob5 572 35 , , , cord-006856-b1w25ob5 572 36 3 3 CD cord-006856-b1w25ob5 572 37 , , , cord-006856-b1w25ob5 572 38 12 12 CD cord-006856-b1w25ob5 572 39 and and CC cord-006856-b1w25ob5 572 40 24 24 CD cord-006856-b1w25ob5 572 41 months month NNS cord-006856-b1w25ob5 572 42 after after IN cord-006856-b1w25ob5 572 43 surgery surgery NN cord-006856-b1w25ob5 572 44 . . . cord-006856-b1w25ob5 573 1 Postoperative postoperative JJ cord-006856-b1w25ob5 573 2 mean mean JJ cord-006856-b1w25ob5 573 3 big big JJ cord-006856-b1w25ob5 573 4 ET-1 ET-1 NNP cord-006856-b1w25ob5 573 5 lev lev NNP cord-006856-b1w25ob5 573 6 - - HYPH cord-006856-b1w25ob5 573 7 els els NNP cord-006856-b1w25ob5 573 8 correlated correlate VBD cord-006856-b1w25ob5 573 9 significantly significantly RB cord-006856-b1w25ob5 573 10 with with IN cord-006856-b1w25ob5 573 11 the the DT cord-006856-b1w25ob5 573 12 maximum maximum JJ cord-006856-b1w25ob5 573 13 percent percent NN cord-006856-b1w25ob5 573 14 decrease decrease NN cord-006856-b1w25ob5 573 15 of of IN cord-006856-b1w25ob5 573 16 GFR GFR NNP cord-006856-b1w25ob5 573 17 within within IN cord-006856-b1w25ob5 573 18 3 3 CD cord-006856-b1w25ob5 573 19 days day NNS cord-006856-b1w25ob5 573 20 after after IN cord-006856-b1w25ob5 573 21 OLT OLT NNP cord-006856-b1w25ob5 573 22 ( ( -LRB- cord-006856-b1w25ob5 573 23 P p NN cord-006856-b1w25ob5 573 24 < < XX cord-006856-b1w25ob5 573 25 0.01 0.01 CD cord-006856-b1w25ob5 573 26 ) ) -RRB- cord-006856-b1w25ob5 573 27 . . . cord-006856-b1w25ob5 574 1 The the DT cord-006856-b1w25ob5 574 2 proportion proportion NN cord-006856-b1w25ob5 574 3 of of IN cord-006856-b1w25ob5 574 4 patients patient NNS cord-006856-b1w25ob5 574 5 who who WP cord-006856-b1w25ob5 574 6 developed develop VBD cord-006856-b1w25ob5 574 7 ARDF ARDF NNP cord-006856-b1w25ob5 574 8 was be VBD cord-006856-b1w25ob5 574 9 significantly significantly RB cord-006856-b1w25ob5 574 10 correlated correlate VBN cord-006856-b1w25ob5 574 11 to to TO cord-006856-b1w25ob5 574 12 mean mean VB cord-006856-b1w25ob5 574 13 postoperative postoperative JJ cord-006856-b1w25ob5 574 14 big big JJ cord-006856-b1w25ob5 574 15 ET-1 ET-1 NNP cord-006856-b1w25ob5 574 16 quartiles quartile NNS cord-006856-b1w25ob5 574 17 ( ( -LRB- cord-006856-b1w25ob5 574 18 P p NN cord-006856-b1w25ob5 574 19 < < XX cord-006856-b1w25ob5 574 20 0.01 0.01 CD cord-006856-b1w25ob5 574 21 ) ) -RRB- cord-006856-b1w25ob5 574 22 . . . cord-006856-b1w25ob5 575 1 In in IN cord-006856-b1w25ob5 575 2 the the DT cord-006856-b1w25ob5 575 3 ARDF ARDF NNP cord-006856-b1w25ob5 575 4 group group NN cord-006856-b1w25ob5 575 5 , , , cord-006856-b1w25ob5 575 6 the the DT cord-006856-b1w25ob5 575 7 percent percent NN cord-006856-b1w25ob5 575 8 decrease decrease NN cord-006856-b1w25ob5 575 9 of of IN cord-006856-b1w25ob5 575 10 GFR GFR NNP cord-006856-b1w25ob5 575 11 within within IN cord-006856-b1w25ob5 575 12 24 24 CD cord-006856-b1w25ob5 575 13 months month NNS cord-006856-b1w25ob5 575 14 was be VBD cord-006856-b1w25ob5 575 15 significantly significantly RB cord-006856-b1w25ob5 575 16 higher high JJR cord-006856-b1w25ob5 575 17 ( ( -LRB- cord-006856-b1w25ob5 575 18 P p NN cord-006856-b1w25ob5 575 19 < < XX cord-006856-b1w25ob5 575 20 0.05 0.05 CD cord-006856-b1w25ob5 575 21 ) ) -RRB- cord-006856-b1w25ob5 575 22 as as IN cord-006856-b1w25ob5 575 23 compared compare VBN cord-006856-b1w25ob5 575 24 to to IN cord-006856-b1w25ob5 575 25 the the DT cord-006856-b1w25ob5 575 26 non non JJ cord-006856-b1w25ob5 575 27 - - JJ cord-006856-b1w25ob5 575 28 ARDF ardf JJ cord-006856-b1w25ob5 575 29 group group NN cord-006856-b1w25ob5 575 30 . . . cord-006856-b1w25ob5 576 1 In in IN cord-006856-b1w25ob5 576 2 conclusion conclusion NN cord-006856-b1w25ob5 576 3 , , , cord-006856-b1w25ob5 576 4 patients patient NNS cord-006856-b1w25ob5 576 5 who who WP cord-006856-b1w25ob5 576 6 develop develop VBP cord-006856-b1w25ob5 576 7 acute acute JJ cord-006856-b1w25ob5 576 8 renal renal JJ cord-006856-b1w25ob5 576 9 dysfunction dysfunction NN cord-006856-b1w25ob5 576 10 immediately immediately RB cord-006856-b1w25ob5 576 11 after after IN cord-006856-b1w25ob5 576 12 OLT OLT NNP cord-006856-b1w25ob5 576 13 do do VBP cord-006856-b1w25ob5 576 14 not not RB cord-006856-b1w25ob5 576 15 fully fully RB cord-006856-b1w25ob5 576 16 recover recover VB cord-006856-b1w25ob5 576 17 to to TO cord-006856-b1w25ob5 576 18 baseline baseline VB cord-006856-b1w25ob5 576 19 regarding regard VBG cord-006856-b1w25ob5 576 20 long long JJ cord-006856-b1w25ob5 576 21 - - HYPH cord-006856-b1w25ob5 576 22 term term NN cord-006856-b1w25ob5 576 23 kidney kidney NN cord-006856-b1w25ob5 576 24 function function NN cord-006856-b1w25ob5 576 25 . . . cord-006856-b1w25ob5 577 1 Short short JJ cord-006856-b1w25ob5 577 2 - - HYPH cord-006856-b1w25ob5 577 3 term term NN cord-006856-b1w25ob5 577 4 GFR GFR NNP cord-006856-b1w25ob5 577 5 was be VBD cord-006856-b1w25ob5 577 6 significantly significantly RB cord-006856-b1w25ob5 577 7 correlated correlate VBN cord-006856-b1w25ob5 577 8 with with IN cord-006856-b1w25ob5 577 9 postoperative postoperative JJ cord-006856-b1w25ob5 577 10 big big JJ cord-006856-b1w25ob5 577 11 ET-1 ET-1 NNP cord-006856-b1w25ob5 577 12 plasma plasma NN cord-006856-b1w25ob5 577 13 levels level NNS cord-006856-b1w25ob5 577 14 , , , cord-006856-b1w25ob5 577 15 suggesting suggest VBG cord-006856-b1w25ob5 577 16 renal renal JJ cord-006856-b1w25ob5 577 17 dysfunction dysfunction NN cord-006856-b1w25ob5 577 18 is be VBZ cord-006856-b1w25ob5 577 19 mediated mediate VBN cord-006856-b1w25ob5 577 20 by by IN cord-006856-b1w25ob5 577 21 the the DT cord-006856-b1w25ob5 577 22 activated activate VBN cord-006856-b1w25ob5 577 23 endothelin endothelin NN cord-006856-b1w25ob5 577 24 system system NN cord-006856-b1w25ob5 577 25 . . . cord-006856-b1w25ob5 578 1 Background background NN cord-006856-b1w25ob5 578 2 . . . cord-006856-b1w25ob5 579 1 With with IN cord-006856-b1w25ob5 579 2 improved improve VBN cord-006856-b1w25ob5 579 3 survival survival NN cord-006856-b1w25ob5 579 4 of of IN cord-006856-b1w25ob5 579 5 liver liver NN cord-006856-b1w25ob5 579 6 transplant transplant NN cord-006856-b1w25ob5 579 7 recipients recipient NNS cord-006856-b1w25ob5 579 8 , , , cord-006856-b1w25ob5 579 9 chronic chronic JJ cord-006856-b1w25ob5 579 10 renal renal JJ cord-006856-b1w25ob5 579 11 failure failure NN cord-006856-b1w25ob5 579 12 has have VBZ cord-006856-b1w25ob5 579 13 become become VBN cord-006856-b1w25ob5 579 14 an an DT cord-006856-b1w25ob5 579 15 important important JJ cord-006856-b1w25ob5 579 16 cause cause NN cord-006856-b1w25ob5 579 17 of of IN cord-006856-b1w25ob5 579 18 morbidity morbidity NN cord-006856-b1w25ob5 579 19 and and CC cord-006856-b1w25ob5 579 20 is be VBZ cord-006856-b1w25ob5 579 21 associated associate VBN cord-006856-b1w25ob5 579 22 with with IN cord-006856-b1w25ob5 579 23 a a DT cord-006856-b1w25ob5 579 24 high high JJ cord-006856-b1w25ob5 579 25 mortality mortality NN cord-006856-b1w25ob5 579 26 . . . cord-006856-b1w25ob5 580 1 Serum serum NN cord-006856-b1w25ob5 580 2 creatinine creatinine NN cord-006856-b1w25ob5 580 3 is be VBZ cord-006856-b1w25ob5 580 4 widely widely RB cord-006856-b1w25ob5 580 5 used use VBN cord-006856-b1w25ob5 580 6 as as IN cord-006856-b1w25ob5 580 7 marker marker NN cord-006856-b1w25ob5 580 8 for for IN cord-006856-b1w25ob5 580 9 renal renal JJ cord-006856-b1w25ob5 580 10 function function NN cord-006856-b1w25ob5 580 11 , , , cord-006856-b1w25ob5 580 12 but but CC cord-006856-b1w25ob5 580 13 it -PRON- PRP cord-006856-b1w25ob5 580 14 depends depend VBZ cord-006856-b1w25ob5 580 15 on on IN cord-006856-b1w25ob5 580 16 various various JJ cord-006856-b1w25ob5 580 17 nonrenal nonrenal JJ cord-006856-b1w25ob5 580 18 factors factor NNS cord-006856-b1w25ob5 580 19 and and CC cord-006856-b1w25ob5 580 20 major major JJ cord-006856-b1w25ob5 580 21 changes change NNS cord-006856-b1w25ob5 580 22 will will MD cord-006856-b1w25ob5 580 23 occur occur VB cord-006856-b1w25ob5 580 24 late late RB cord-006856-b1w25ob5 580 25 in in IN cord-006856-b1w25ob5 580 26 the the DT cord-006856-b1w25ob5 580 27 course course NN cord-006856-b1w25ob5 580 28 of of IN cord-006856-b1w25ob5 580 29 progressive progressive JJ cord-006856-b1w25ob5 580 30 renal renal JJ cord-006856-b1w25ob5 580 31 impairment impairment NN cord-006856-b1w25ob5 580 32 . . . cord-006856-b1w25ob5 581 1 We -PRON- PRP cord-006856-b1w25ob5 581 2 evaluated evaluate VBD cord-006856-b1w25ob5 581 3 cystatin cystatin NN cord-006856-b1w25ob5 581 4 C c NN cord-006856-b1w25ob5 581 5 and and CC cord-006856-b1w25ob5 581 6 urine urine NN cord-006856-b1w25ob5 581 7 microscopy microscopy NN cord-006856-b1w25ob5 581 8 for for IN cord-006856-b1w25ob5 581 9 detection detection NN cord-006856-b1w25ob5 581 10 of of IN cord-006856-b1w25ob5 581 11 renal renal JJ cord-006856-b1w25ob5 581 12 dysfunction dysfunction NN cord-006856-b1w25ob5 581 13 in in IN cord-006856-b1w25ob5 581 14 patients patient NNS cord-006856-b1w25ob5 581 15 after after IN cord-006856-b1w25ob5 581 16 liver liver NN cord-006856-b1w25ob5 581 17 transplantation transplantation NN cord-006856-b1w25ob5 581 18 . . . cord-006856-b1w25ob5 582 1 Methods method NNS cord-006856-b1w25ob5 582 2 . . . cord-006856-b1w25ob5 583 1 From from IN cord-006856-b1w25ob5 583 2 November November NNP cord-006856-b1w25ob5 583 3 2003 2003 CD cord-006856-b1w25ob5 583 4 , , , cord-006856-b1w25ob5 583 5 70 70 CD cord-006856-b1w25ob5 583 6 liver liver NN cord-006856-b1w25ob5 583 7 transplant transplant NN cord-006856-b1w25ob5 583 8 recipients recipient NNS cord-006856-b1w25ob5 583 9 at at IN cord-006856-b1w25ob5 583 10 various various JJ cord-006856-b1w25ob5 583 11 intervals interval NNS cord-006856-b1w25ob5 583 12 from from IN cord-006856-b1w25ob5 583 13 liver liver NN cord-006856-b1w25ob5 583 14 transplantation transplantation NN cord-006856-b1w25ob5 583 15 were be VBD cord-006856-b1w25ob5 583 16 included include VBN cord-006856-b1w25ob5 583 17 to to IN cord-006856-b1w25ob5 583 18 our -PRON- PRP$ cord-006856-b1w25ob5 583 19 follow follow NN cord-006856-b1w25ob5 583 20 - - HYPH cord-006856-b1w25ob5 583 21 up up NN cord-006856-b1w25ob5 583 22 . . . cord-006856-b1w25ob5 584 1 Every every DT cord-006856-b1w25ob5 584 2 three three CD cord-006856-b1w25ob5 584 3 months month NNS cord-006856-b1w25ob5 584 4 we -PRON- PRP cord-006856-b1w25ob5 584 5 investigated investigate VBD cord-006856-b1w25ob5 584 6 serum serum NN cord-006856-b1w25ob5 584 7 creatinine creatinine NN cord-006856-b1w25ob5 584 8 , , , cord-006856-b1w25ob5 584 9 urea urea NN cord-006856-b1w25ob5 584 10 , , , cord-006856-b1w25ob5 584 11 renal renal JJ cord-006856-b1w25ob5 584 12 creatinine creatinine NN cord-006856-b1w25ob5 584 13 clearance clearance NN cord-006856-b1w25ob5 584 14 and and CC cord-006856-b1w25ob5 584 15 cystatin cystatin NN cord-006856-b1w25ob5 584 16 C c NN cord-006856-b1w25ob5 584 17 as as IN cord-006856-b1w25ob5 584 18 marker marker NN cord-006856-b1w25ob5 584 19 for for IN cord-006856-b1w25ob5 584 20 renal renal JJ cord-006856-b1w25ob5 584 21 function function NN cord-006856-b1w25ob5 584 22 . . . cord-006856-b1w25ob5 585 1 Furthermore furthermore RB cord-006856-b1w25ob5 585 2 urinary urinary JJ cord-006856-b1w25ob5 585 3 sediment sediment NN cord-006856-b1w25ob5 585 4 was be VBD cord-006856-b1w25ob5 585 5 examined examine VBN cord-006856-b1w25ob5 585 6 by by IN cord-006856-b1w25ob5 585 7 urinary urinary JJ cord-006856-b1w25ob5 585 8 test test NN cord-006856-b1w25ob5 585 9 , , , cord-006856-b1w25ob5 585 10 automated automate VBN cord-006856-b1w25ob5 585 11 urinary urinary JJ cord-006856-b1w25ob5 585 12 sediment sediment NN cord-006856-b1w25ob5 585 13 analyser analyser NN cord-006856-b1w25ob5 585 14 , , , cord-006856-b1w25ob5 585 15 and and CC cord-006856-b1w25ob5 585 16 urine urine NN cord-006856-b1w25ob5 585 17 microscopy microscopy NN cord-006856-b1w25ob5 585 18 . . . cord-006856-b1w25ob5 586 1 In in IN cord-006856-b1w25ob5 586 2 patients patient NNS cord-006856-b1w25ob5 586 3 with with IN cord-006856-b1w25ob5 586 4 reference reference NN cord-006856-b1w25ob5 586 5 to to IN cord-006856-b1w25ob5 586 6 renal renal JJ cord-006856-b1w25ob5 586 7 deterioration deterioration NN cord-006856-b1w25ob5 586 8 we -PRON- PRP cord-006856-b1w25ob5 586 9 tried try VBD cord-006856-b1w25ob5 586 10 to to TO cord-006856-b1w25ob5 586 11 decrease decrease VB cord-006856-b1w25ob5 586 12 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 586 13 therapy therapy NN cord-006856-b1w25ob5 586 14 , , , cord-006856-b1w25ob5 586 15 to to TO cord-006856-b1w25ob5 586 16 optimize optimize VB cord-006856-b1w25ob5 586 17 the the DT cord-006856-b1w25ob5 586 18 blood blood NN cord-006856-b1w25ob5 586 19 pressure pressure NN cord-006856-b1w25ob5 586 20 , , , cord-006856-b1w25ob5 586 21 and and CC cord-006856-b1w25ob5 586 22 to to TO cord-006856-b1w25ob5 586 23 discontinue discontinue VB cord-006856-b1w25ob5 586 24 nephrotoxic nephrotoxic NNP cord-006856-b1w25ob5 586 25 medication medication NN cord-006856-b1w25ob5 586 26 . . . cord-006856-b1w25ob5 587 1 Infections infection NNS cord-006856-b1w25ob5 587 2 were be VBD cord-006856-b1w25ob5 587 3 detected detect VBN cord-006856-b1w25ob5 587 4 early early RB cord-006856-b1w25ob5 587 5 by by IN cord-006856-b1w25ob5 587 6 urine urine NN cord-006856-b1w25ob5 587 7 microscopy microscopy NNS cord-006856-b1w25ob5 587 8 and and CC cord-006856-b1w25ob5 587 9 treated treat VBN cord-006856-b1w25ob5 587 10 , , , cord-006856-b1w25ob5 587 11 even even RB cord-006856-b1w25ob5 587 12 when when WRB cord-006856-b1w25ob5 587 13 there there EX cord-006856-b1w25ob5 587 14 was be VBD cord-006856-b1w25ob5 587 15 no no DT cord-006856-b1w25ob5 587 16 clinical clinical JJ cord-006856-b1w25ob5 587 17 appearance appearance NN cord-006856-b1w25ob5 587 18 and and CC cord-006856-b1w25ob5 587 19 the the DT cord-006856-b1w25ob5 587 20 urinary urinary JJ cord-006856-b1w25ob5 587 21 test test NN cord-006856-b1w25ob5 587 22 was be VBD cord-006856-b1w25ob5 587 23 negative negative JJ cord-006856-b1w25ob5 587 24 . . . cord-006856-b1w25ob5 588 1 Results result NNS cord-006856-b1w25ob5 588 2 . . . cord-006856-b1w25ob5 589 1 The the DT cord-006856-b1w25ob5 589 2 results result NNS cord-006856-b1w25ob5 589 3 of of IN cord-006856-b1w25ob5 589 4 our -PRON- PRP$ cord-006856-b1w25ob5 589 5 study study NN cord-006856-b1w25ob5 589 6 showed show VBD cord-006856-b1w25ob5 589 7 that that IN cord-006856-b1w25ob5 589 8 concerning concern VBG cord-006856-b1w25ob5 589 9 the the DT cord-006856-b1w25ob5 589 10 renal renal JJ cord-006856-b1w25ob5 589 11 function function NN cord-006856-b1w25ob5 589 12 , , , cord-006856-b1w25ob5 589 13 cystatin cystatin NNP cord-006856-b1w25ob5 589 14 C C NNP cord-006856-b1w25ob5 589 15 is be VBZ cord-006856-b1w25ob5 589 16 more more RBR cord-006856-b1w25ob5 589 17 sensitive sensitive JJ cord-006856-b1w25ob5 589 18 than than IN cord-006856-b1w25ob5 589 19 creatinine creatinine NN cord-006856-b1w25ob5 589 20 and and CC cord-006856-b1w25ob5 589 21 creatinine creatinine NN cord-006856-b1w25ob5 589 22 clearance clearance NN cord-006856-b1w25ob5 589 23 . . . cord-006856-b1w25ob5 590 1 The the DT cord-006856-b1w25ob5 590 2 microscopy microscopy NNS cord-006856-b1w25ob5 590 3 of of IN cord-006856-b1w25ob5 590 4 the the DT cord-006856-b1w25ob5 590 5 urine urine NN cord-006856-b1w25ob5 590 6 sediment sediment NN cord-006856-b1w25ob5 590 7 showed show VBD cord-006856-b1w25ob5 590 8 the the DT cord-006856-b1w25ob5 590 9 highest high JJS cord-006856-b1w25ob5 590 10 sensitivity sensitivity NN cord-006856-b1w25ob5 590 11 compared compare VBN cord-006856-b1w25ob5 590 12 with with IN cord-006856-b1w25ob5 590 13 the the DT cord-006856-b1w25ob5 590 14 other other JJ cord-006856-b1w25ob5 590 15 methods method NNS cord-006856-b1w25ob5 590 16 . . . cord-006856-b1w25ob5 591 1 Concerning concern VBG cord-006856-b1w25ob5 591 2 damages damage NNS cord-006856-b1w25ob5 591 3 of of IN cord-006856-b1w25ob5 591 4 the the DT cord-006856-b1w25ob5 591 5 kidney kidney NN cord-006856-b1w25ob5 591 6 , , , cord-006856-b1w25ob5 591 7 urine urine NN cord-006856-b1w25ob5 591 8 microscopy microscopy NNS cord-006856-b1w25ob5 591 9 offered offer VBD cord-006856-b1w25ob5 591 10 the the DT cord-006856-b1w25ob5 591 11 best good JJS cord-006856-b1w25ob5 591 12 possibility possibility NN cord-006856-b1w25ob5 591 13 to to TO cord-006856-b1w25ob5 591 14 identify identify VB cord-006856-b1w25ob5 591 15 the the DT cord-006856-b1w25ob5 591 16 etiology etiology NN cord-006856-b1w25ob5 591 17 . . . cord-006856-b1w25ob5 592 1 During during IN cord-006856-b1w25ob5 592 2 the the DT cord-006856-b1w25ob5 592 3 follow follow NN cord-006856-b1w25ob5 592 4 - - HYPH cord-006856-b1w25ob5 592 5 up up NN cord-006856-b1w25ob5 592 6 and and CC cord-006856-b1w25ob5 592 7 after after IN cord-006856-b1w25ob5 592 8 adequate adequate JJ cord-006856-b1w25ob5 592 9 and and CC cord-006856-b1w25ob5 592 10 early early JJ cord-006856-b1w25ob5 592 11 therapy therapy NN cord-006856-b1w25ob5 592 12 , , , cord-006856-b1w25ob5 592 13 fifteen fifteen CD cord-006856-b1w25ob5 592 14 patients patient NNS cord-006856-b1w25ob5 592 15 ( ( -LRB- cord-006856-b1w25ob5 592 16 21.4 21.4 CD cord-006856-b1w25ob5 592 17 % % NN cord-006856-b1w25ob5 592 18 ) ) -RRB- cord-006856-b1w25ob5 592 19 showed show VBD cord-006856-b1w25ob5 592 20 an an DT cord-006856-b1w25ob5 592 21 amelioration amelioration NN cord-006856-b1w25ob5 592 22 of of IN cord-006856-b1w25ob5 592 23 renal renal JJ cord-006856-b1w25ob5 592 24 function function NN cord-006856-b1w25ob5 592 25 after after IN cord-006856-b1w25ob5 592 26 a a DT cord-006856-b1w25ob5 592 27 few few JJ cord-006856-b1w25ob5 592 28 months month NNS cord-006856-b1w25ob5 592 29 . . . cord-006856-b1w25ob5 593 1 In in IN cord-006856-b1w25ob5 593 2 3 3 CD cord-006856-b1w25ob5 593 3 patients patient NNS cord-006856-b1w25ob5 593 4 ( ( -LRB- cord-006856-b1w25ob5 593 5 4.2 4.2 CD cord-006856-b1w25ob5 593 6 % % NN cord-006856-b1w25ob5 593 7 ) ) -RRB- cord-006856-b1w25ob5 593 8 there there EX cord-006856-b1w25ob5 593 9 was be VBD cord-006856-b1w25ob5 593 10 a a DT cord-006856-b1w25ob5 593 11 marked marked JJ cord-006856-b1w25ob5 593 12 deterioration deterioration NN cord-006856-b1w25ob5 593 13 . . . cord-006856-b1w25ob5 594 1 Two two CD cord-006856-b1w25ob5 594 2 of of IN cord-006856-b1w25ob5 594 3 them -PRON- PRP cord-006856-b1w25ob5 594 4 had have VBD cord-006856-b1w25ob5 594 5 to to TO cord-006856-b1w25ob5 594 6 receive receive VB cord-006856-b1w25ob5 594 7 a a DT cord-006856-b1w25ob5 594 8 higher high JJR cord-006856-b1w25ob5 594 9 dose dose NN cord-006856-b1w25ob5 594 10 of of IN cord-006856-b1w25ob5 594 11 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 594 12 therapy therapy NN cord-006856-b1w25ob5 594 13 and and CC cord-006856-b1w25ob5 594 14 one one CD cord-006856-b1w25ob5 594 15 had have VBD cord-006856-b1w25ob5 594 16 an an DT cord-006856-b1w25ob5 594 17 infection infection NN cord-006856-b1w25ob5 594 18 which which WDT cord-006856-b1w25ob5 594 19 was be VBD cord-006856-b1w25ob5 594 20 treated treat VBN cord-006856-b1w25ob5 594 21 with with IN cord-006856-b1w25ob5 594 22 nephrotoxic nephrotoxic NNP cord-006856-b1w25ob5 594 23 medication medication NNP cord-006856-b1w25ob5 594 24 . . . cord-006856-b1w25ob5 595 1 Conclusions conclusion NNS cord-006856-b1w25ob5 595 2 . . . cord-006856-b1w25ob5 596 1 The the DT cord-006856-b1w25ob5 596 2 early early JJ cord-006856-b1w25ob5 596 3 identification identification NN cord-006856-b1w25ob5 596 4 of of IN cord-006856-b1w25ob5 596 5 renal renal JJ cord-006856-b1w25ob5 596 6 failure failure NN cord-006856-b1w25ob5 596 7 and and CC cord-006856-b1w25ob5 596 8 its -PRON- PRP$ cord-006856-b1w25ob5 596 9 etiology etiology NN cord-006856-b1w25ob5 596 10 are be VBP cord-006856-b1w25ob5 596 11 necessary necessary JJ cord-006856-b1w25ob5 596 12 in in IN cord-006856-b1w25ob5 596 13 patients patient NNS cord-006856-b1w25ob5 596 14 after after IN cord-006856-b1w25ob5 596 15 liver liver NN cord-006856-b1w25ob5 596 16 transplantation transplantation NN cord-006856-b1w25ob5 596 17 . . . cord-006856-b1w25ob5 597 1 The the DT cord-006856-b1w25ob5 597 2 results result NNS cord-006856-b1w25ob5 597 3 of of IN cord-006856-b1w25ob5 597 4 our -PRON- PRP$ cord-006856-b1w25ob5 597 5 study study NN cord-006856-b1w25ob5 597 6 confirmed confirm VBD cord-006856-b1w25ob5 597 7 cystatin cystatin NNP cord-006856-b1w25ob5 597 8 C C NNP cord-006856-b1w25ob5 597 9 as as IN cord-006856-b1w25ob5 597 10 early early JJ cord-006856-b1w25ob5 597 11 prognostic prognostic JJ cord-006856-b1w25ob5 597 12 marker marker NN cord-006856-b1w25ob5 597 13 for for IN cord-006856-b1w25ob5 597 14 patients patient NNS cord-006856-b1w25ob5 597 15 with with IN cord-006856-b1w25ob5 597 16 renal renal JJ cord-006856-b1w25ob5 597 17 dysfunction dysfunction NN cord-006856-b1w25ob5 597 18 . . . cord-006856-b1w25ob5 598 1 In in IN cord-006856-b1w25ob5 598 2 combination combination NN cord-006856-b1w25ob5 598 3 with with IN cord-006856-b1w25ob5 598 4 urine urine NN cord-006856-b1w25ob5 598 5 microscopy microscopy NN cord-006856-b1w25ob5 598 6 , , , cord-006856-b1w25ob5 598 7 renal renal JJ cord-006856-b1w25ob5 598 8 dysfunction dysfunction NN cord-006856-b1w25ob5 598 9 could could MD cord-006856-b1w25ob5 598 10 be be VB cord-006856-b1w25ob5 598 11 detected detect VBN cord-006856-b1w25ob5 598 12 in in IN cord-006856-b1w25ob5 598 13 time time NN cord-006856-b1w25ob5 598 14 and and CC cord-006856-b1w25ob5 598 15 renal renal JJ cord-006856-b1w25ob5 598 16 function function NN cord-006856-b1w25ob5 598 17 could could MD cord-006856-b1w25ob5 598 18 be be VB cord-006856-b1w25ob5 598 19 protected protect VBN cord-006856-b1w25ob5 598 20 with with IN cord-006856-b1w25ob5 598 21 an an DT cord-006856-b1w25ob5 598 22 adequate adequate JJ cord-006856-b1w25ob5 598 23 therapy therapy NN cord-006856-b1w25ob5 598 24 . . . cord-006856-b1w25ob5 599 1 Background background NN cord-006856-b1w25ob5 599 2 . . . cord-006856-b1w25ob5 600 1 HCV HCV NNP cord-006856-b1w25ob5 600 2 - - HYPH cord-006856-b1w25ob5 600 3 infected infect VBN cord-006856-b1w25ob5 600 4 patients patient NNS cord-006856-b1w25ob5 600 5 and and CC cord-006856-b1w25ob5 600 6 their -PRON- PRP$ cord-006856-b1w25ob5 600 7 grafts graft NNS cord-006856-b1w25ob5 600 8 have have VBP cord-006856-b1w25ob5 600 9 short short JJ cord-006856-b1w25ob5 600 10 - - HYPH cord-006856-b1w25ob5 600 11 term term NN cord-006856-b1w25ob5 600 12 survival survival NN cord-006856-b1w25ob5 600 13 rates rate NNS cord-006856-b1w25ob5 600 14 similiar similiar JJ cord-006856-b1w25ob5 600 15 to to IN cord-006856-b1w25ob5 600 16 other other JJ cord-006856-b1w25ob5 600 17 indications indication NNS cord-006856-b1w25ob5 600 18 . . . cord-006856-b1w25ob5 601 1 Recent recent JJ cord-006856-b1w25ob5 601 2 data datum NNS cord-006856-b1w25ob5 601 3 on on IN cord-006856-b1w25ob5 601 4 long long JJ cord-006856-b1w25ob5 601 5 - - HYPH cord-006856-b1w25ob5 601 6 term term NN cord-006856-b1w25ob5 601 7 outcome outcome NN cord-006856-b1w25ob5 601 8 are be VBP cord-006856-b1w25ob5 601 9 contradictory contradictory JJ cord-006856-b1w25ob5 601 10 , , , cord-006856-b1w25ob5 601 11 showing show VBG cord-006856-b1w25ob5 601 12 a a DT cord-006856-b1w25ob5 601 13 trend trend NN cord-006856-b1w25ob5 601 14 towards towards IN cord-006856-b1w25ob5 601 15 poorer poor JJR cord-006856-b1w25ob5 601 16 outcome outcome NN cord-006856-b1w25ob5 601 17 in in IN cord-006856-b1w25ob5 601 18 patients patient NNS cord-006856-b1w25ob5 601 19 transplanted transplant VBN cord-006856-b1w25ob5 601 20 for for IN cord-006856-b1w25ob5 601 21 HCV HCV NNP cord-006856-b1w25ob5 601 22 cirrhosis cirrhosis NN cord-006856-b1w25ob5 601 23 . . . cord-006856-b1w25ob5 602 1 In in IN cord-006856-b1w25ob5 602 2 this this DT cord-006856-b1w25ob5 602 3 study study NN cord-006856-b1w25ob5 602 4 we -PRON- PRP cord-006856-b1w25ob5 602 5 present present VBP cord-006856-b1w25ob5 602 6 a a DT cord-006856-b1w25ob5 602 7 retrospective retrospective JJ cord-006856-b1w25ob5 602 8 analysis analysis NN cord-006856-b1w25ob5 602 9 of of IN cord-006856-b1w25ob5 602 10 our -PRON- PRP$ cord-006856-b1w25ob5 602 11 experience experience NN cord-006856-b1w25ob5 602 12 with with IN cord-006856-b1w25ob5 602 13 patients patient NNS cord-006856-b1w25ob5 602 14 who who WP cord-006856-b1w25ob5 602 15 underwent undergo VBD cord-006856-b1w25ob5 602 16 liver liver NN cord-006856-b1w25ob5 602 17 transplantation transplantation NN cord-006856-b1w25ob5 602 18 ( ( -LRB- cord-006856-b1w25ob5 602 19 LT LT NNP cord-006856-b1w25ob5 602 20 ) ) -RRB- cord-006856-b1w25ob5 602 21 due due IN cord-006856-b1w25ob5 602 22 to to IN cord-006856-b1w25ob5 602 23 HCV HCV NNP cord-006856-b1w25ob5 602 24 - - HYPH cord-006856-b1w25ob5 602 25 associated associate VBN cord-006856-b1w25ob5 602 26 end end NN cord-006856-b1w25ob5 602 27 stage stage NN cord-006856-b1w25ob5 602 28 liver liver NN cord-006856-b1w25ob5 602 29 disease disease NN cord-006856-b1w25ob5 602 30 . . . cord-006856-b1w25ob5 603 1 Methods method NNS cord-006856-b1w25ob5 603 2 . . . cord-006856-b1w25ob5 604 1 Patients patient NNS cord-006856-b1w25ob5 604 2 ' ' POS cord-006856-b1w25ob5 604 3 charts chart NNS cord-006856-b1w25ob5 604 4 were be VBD cord-006856-b1w25ob5 604 5 reviewed review VBN cord-006856-b1w25ob5 604 6 for for IN cord-006856-b1w25ob5 604 7 survival survival NN cord-006856-b1w25ob5 604 8 , , , cord-006856-b1w25ob5 604 9 histologically histologically RB cord-006856-b1w25ob5 604 10 defined define VBD cord-006856-b1w25ob5 604 11 HCV HCV NNP cord-006856-b1w25ob5 604 12 recurrence recurrence NN cord-006856-b1w25ob5 604 13 , , , cord-006856-b1w25ob5 604 14 genotype genotype NN cord-006856-b1w25ob5 604 15 , , , cord-006856-b1w25ob5 604 16 presence presence NN cord-006856-b1w25ob5 604 17 of of IN cord-006856-b1w25ob5 604 18 cirrhosis cirrhosis NN cord-006856-b1w25ob5 604 19 , , , cord-006856-b1w25ob5 604 20 donor donor NN cord-006856-b1w25ob5 604 21 and and CC cord-006856-b1w25ob5 604 22 recipient recipient NN cord-006856-b1w25ob5 604 23 age age NN cord-006856-b1w25ob5 604 24 as as RB cord-006856-b1w25ob5 604 25 well well RB cord-006856-b1w25ob5 604 26 as as IN cord-006856-b1w25ob5 604 27 type type NN cord-006856-b1w25ob5 604 28 of of IN cord-006856-b1w25ob5 604 29 immunosuppression immunosuppression NN cord-006856-b1w25ob5 604 30 ( ( -LRB- cord-006856-b1w25ob5 604 31 cyclosporine cyclosporine NN cord-006856-b1w25ob5 604 32 and and CC cord-006856-b1w25ob5 604 33 tacrolimus tacrolimus NN cord-006856-b1w25ob5 604 34 ; ; : cord-006856-b1w25ob5 604 35 azathioprine azathioprine NNP cord-006856-b1w25ob5 604 36 and and CC cord-006856-b1w25ob5 604 37 mycophenolate mycophenolate NNP cord-006856-b1w25ob5 604 38 mofetil mofetil NNP cord-006856-b1w25ob5 604 39 ) ) -RRB- cord-006856-b1w25ob5 604 40 . . . cord-006856-b1w25ob5 605 1 Survival survival NN cord-006856-b1w25ob5 605 2 was be VBD cord-006856-b1w25ob5 605 3 analysed analyse VBN cord-006856-b1w25ob5 605 4 by by IN cord-006856-b1w25ob5 605 5 the the DT cord-006856-b1w25ob5 605 6 Kaplan Kaplan NNP cord-006856-b1w25ob5 605 7 - - HYPH cord-006856-b1w25ob5 605 8 Meier Meier NNP cord-006856-b1w25ob5 605 9 procedure procedure NN cord-006856-b1w25ob5 605 10 , , , cord-006856-b1w25ob5 605 11 the the DT cord-006856-b1w25ob5 605 12 influence influence NN cord-006856-b1w25ob5 605 13 of of IN cord-006856-b1w25ob5 605 14 baseline baseline JJ cord-006856-b1w25ob5 605 15 variables variable NNS cord-006856-b1w25ob5 605 16 was be VBD cord-006856-b1w25ob5 605 17 analysed analyse VBN cord-006856-b1w25ob5 605 18 by by IN cord-006856-b1w25ob5 605 19 binary binary JJ cord-006856-b1w25ob5 605 20 logistic logistic JJ cord-006856-b1w25ob5 605 21 regression regression NN cord-006856-b1w25ob5 605 22 . . . cord-006856-b1w25ob5 606 1 Results result NNS cord-006856-b1w25ob5 606 2 . . . cord-006856-b1w25ob5 607 1 Between between IN cord-006856-b1w25ob5 607 2 1986 1986 CD cord-006856-b1w25ob5 607 3 and and CC cord-006856-b1w25ob5 607 4 October October NNP cord-006856-b1w25ob5 607 5 2004 2004 CD cord-006856-b1w25ob5 607 6 , , , cord-006856-b1w25ob5 607 7 162 162 CD cord-006856-b1w25ob5 607 8 patients patient NNS cord-006856-b1w25ob5 607 9 were be VBD cord-006856-b1w25ob5 607 10 transplanted transplant VBN cord-006856-b1w25ob5 607 11 for for IN cord-006856-b1w25ob5 607 12 HCV HCV NNP cord-006856-b1w25ob5 607 13 - - HYPH cord-006856-b1w25ob5 607 14 related relate VBN cord-006856-b1w25ob5 607 15 cirrhosis cirrhosis NN cord-006856-b1w25ob5 607 16 . . . cord-006856-b1w25ob5 608 1 Ten ten CD cord-006856-b1w25ob5 608 2 pts pts NN cord-006856-b1w25ob5 608 3 . . . cord-006856-b1w25ob5 609 1 received receive VBD cord-006856-b1w25ob5 609 2 one one CD cord-006856-b1w25ob5 609 3 and and CC cord-006856-b1w25ob5 609 4 3 3 CD cord-006856-b1w25ob5 609 5 pts pts NN cord-006856-b1w25ob5 609 6 . . . cord-006856-b1w25ob5 610 1 two two CD cord-006856-b1w25ob5 610 2 reLTs relts CD cord-006856-b1w25ob5 610 3 . . . cord-006856-b1w25ob5 611 1 In in IN cord-006856-b1w25ob5 611 2 3 3 CD cord-006856-b1w25ob5 611 3 ( ( -LRB- cord-006856-b1w25ob5 611 4 23 23 CD cord-006856-b1w25ob5 611 5 % % NN cord-006856-b1w25ob5 611 6 ) ) -RRB- cord-006856-b1w25ob5 611 7 pts pts NN cord-006856-b1w25ob5 611 8 . . . cord-006856-b1w25ob5 612 1 recurrent recurrent JJ cord-006856-b1w25ob5 612 2 hepatits hepatit NNS cord-006856-b1w25ob5 612 3 C C NNP cord-006856-b1w25ob5 612 4 was be VBD cord-006856-b1w25ob5 612 5 the the DT cord-006856-b1w25ob5 612 6 cause cause NN cord-006856-b1w25ob5 612 7 for for IN cord-006856-b1w25ob5 612 8 reLT relt NN cord-006856-b1w25ob5 612 9 , , , cord-006856-b1w25ob5 612 10 in in IN cord-006856-b1w25ob5 612 11 10 10 CD cord-006856-b1w25ob5 612 12 vascular vascular JJ cord-006856-b1w25ob5 612 13 and/or and/or CC cord-006856-b1w25ob5 612 14 biliary biliary JJ cord-006856-b1w25ob5 612 15 complications complication NNS cord-006856-b1w25ob5 612 16 . . . cord-006856-b1w25ob5 613 1 Hepatitis Hepatitis NNP cord-006856-b1w25ob5 613 2 B B NNP cord-006856-b1w25ob5 613 3 coinfection coinfection NN cord-006856-b1w25ob5 613 4 was be VBD cord-006856-b1w25ob5 613 5 present present JJ cord-006856-b1w25ob5 613 6 in in IN cord-006856-b1w25ob5 613 7 6 6 CD cord-006856-b1w25ob5 613 8 patients patient NNS cord-006856-b1w25ob5 613 9 . . . cord-006856-b1w25ob5 614 1 Median median JJ cord-006856-b1w25ob5 614 2 follow follow NN cord-006856-b1w25ob5 614 3 - - HYPH cord-006856-b1w25ob5 614 4 up up NN cord-006856-b1w25ob5 614 5 was be VBD cord-006856-b1w25ob5 614 6 44 44 CD cord-006856-b1w25ob5 614 7 months month NNS cord-006856-b1w25ob5 615 1 ( ( -LRB- cord-006856-b1w25ob5 615 2 range range NN cord-006856-b1w25ob5 615 3 , , , cord-006856-b1w25ob5 615 4 0.6 0.6 CD cord-006856-b1w25ob5 615 5 - - SYM cord-006856-b1w25ob5 615 6 221 221 CD cord-006856-b1w25ob5 615 7 ) ) -RRB- cord-006856-b1w25ob5 615 8 . . . cord-006856-b1w25ob5 616 1 The the DT cord-006856-b1w25ob5 616 2 overall overall JJ cord-006856-b1w25ob5 616 3 , , , cord-006856-b1w25ob5 616 4 1- 1- CD cord-006856-b1w25ob5 616 5 , , , cord-006856-b1w25ob5 616 6 2- 2- CD cord-006856-b1w25ob5 616 7 , , , cord-006856-b1w25ob5 617 1 3- 3- LS cord-006856-b1w25ob5 617 2 , , , cord-006856-b1w25ob5 617 3 5- 5- NNP cord-006856-b1w25ob5 617 4 , , , cord-006856-b1w25ob5 617 5 and and CC cord-006856-b1w25ob5 617 6 10-year 10-year CD cord-006856-b1w25ob5 617 7 survival survival NN cord-006856-b1w25ob5 617 8 rates rate NNS cord-006856-b1w25ob5 617 9 were be VBD cord-006856-b1w25ob5 617 10 86 86 CD cord-006856-b1w25ob5 617 11 % % NN cord-006856-b1w25ob5 617 12 , , , cord-006856-b1w25ob5 617 13 81 81 CD cord-006856-b1w25ob5 617 14 % % NN cord-006856-b1w25ob5 617 15 , , , cord-006856-b1w25ob5 617 16 78 78 CD cord-006856-b1w25ob5 617 17 % % NN cord-006856-b1w25ob5 617 18 , , , cord-006856-b1w25ob5 617 19 71 71 CD cord-006856-b1w25ob5 617 20 % % NN cord-006856-b1w25ob5 617 21 , , , cord-006856-b1w25ob5 617 22 and and CC cord-006856-b1w25ob5 617 23 59 59 CD cord-006856-b1w25ob5 617 24 % % NN cord-006856-b1w25ob5 617 25 , , , cord-006856-b1w25ob5 617 26 respectively respectively RB cord-006856-b1w25ob5 617 27 , , , cord-006856-b1w25ob5 617 28 which which WDT cord-006856-b1w25ob5 617 29 were be VBD cord-006856-b1w25ob5 617 30 comparable comparable JJ cord-006856-b1w25ob5 617 31 to to IN cord-006856-b1w25ob5 617 32 other other JJ cord-006856-b1w25ob5 617 33 indications indication NNS cord-006856-b1w25ob5 617 34 . . . cord-006856-b1w25ob5 618 1 The the DT cord-006856-b1w25ob5 618 2 probability probability NN cord-006856-b1w25ob5 618 3 of of IN cord-006856-b1w25ob5 618 4 recurrent recurrent JJ cord-006856-b1w25ob5 618 5 HCV HCV NNP cord-006856-b1w25ob5 618 6 was be VBD cord-006856-b1w25ob5 618 7 34 34 CD cord-006856-b1w25ob5 618 8 % % NN cord-006856-b1w25ob5 618 9 , , , cord-006856-b1w25ob5 618 10 51 51 CD cord-006856-b1w25ob5 618 11 % % NN cord-006856-b1w25ob5 618 12 , , , cord-006856-b1w25ob5 618 13 62 62 CD cord-006856-b1w25ob5 618 14 % % NN cord-006856-b1w25ob5 618 15 , , , cord-006856-b1w25ob5 618 16 70 70 CD cord-006856-b1w25ob5 618 17 % % NN cord-006856-b1w25ob5 618 18 , , , cord-006856-b1w25ob5 618 19 and and CC cord-006856-b1w25ob5 618 20 83 83 CD cord-006856-b1w25ob5 618 21 % % NN cord-006856-b1w25ob5 618 22 after after IN cord-006856-b1w25ob5 618 23 1 1 CD cord-006856-b1w25ob5 618 24 , , , cord-006856-b1w25ob5 618 25 2 2 CD cord-006856-b1w25ob5 618 26 , , , cord-006856-b1w25ob5 618 27 3 3 CD cord-006856-b1w25ob5 618 28 , , , cord-006856-b1w25ob5 618 29 5 5 CD cord-006856-b1w25ob5 618 30 , , , cord-006856-b1w25ob5 618 31 and and CC cord-006856-b1w25ob5 618 32 10 10 CD cord-006856-b1w25ob5 618 33 years year NNS cord-006856-b1w25ob5 618 34 , , , cord-006856-b1w25ob5 618 35 respectively respectively RB cord-006856-b1w25ob5 618 36 , , , cord-006856-b1w25ob5 618 37 post post NN cord-006856-b1w25ob5 618 38 LT LT NNP cord-006856-b1w25ob5 618 39 . . . cord-006856-b1w25ob5 619 1 Nine nine CD cord-006856-b1w25ob5 619 2 ( ( -LRB- cord-006856-b1w25ob5 619 3 6.6 6.6 CD cord-006856-b1w25ob5 619 4 % % NN cord-006856-b1w25ob5 619 5 ) ) -RRB- cord-006856-b1w25ob5 619 6 pts pts NN cord-006856-b1w25ob5 619 7 . . . cord-006856-b1w25ob5 620 1 developed develop VBN cord-006856-b1w25ob5 620 2 cirrhosis cirrhosis NN cord-006856-b1w25ob5 620 3 after after IN cord-006856-b1w25ob5 620 4 a a DT cord-006856-b1w25ob5 620 5 median median NN cord-006856-b1w25ob5 620 6 of of IN cord-006856-b1w25ob5 620 7 50 50 CD cord-006856-b1w25ob5 620 8 months month NNS cord-006856-b1w25ob5 620 9 ( ( -LRB- cord-006856-b1w25ob5 620 10 28 28 CD cord-006856-b1w25ob5 620 11 - - SYM cord-006856-b1w25ob5 620 12 116 116 CD cord-006856-b1w25ob5 620 13 ) ) -RRB- cord-006856-b1w25ob5 620 14 . . . cord-006856-b1w25ob5 621 1 HCV HCV NNP cord-006856-b1w25ob5 621 2 recurrence recurrence NN cord-006856-b1w25ob5 621 3 did do VBD cord-006856-b1w25ob5 621 4 not not RB cord-006856-b1w25ob5 621 5 negatively negatively RB cord-006856-b1w25ob5 621 6 influence influence VB cord-006856-b1w25ob5 621 7 patient patient NN cord-006856-b1w25ob5 621 8 and and CC cord-006856-b1w25ob5 621 9 graft graft NN cord-006856-b1w25ob5 621 10 survival survival NN cord-006856-b1w25ob5 621 11 . . . cord-006856-b1w25ob5 622 1 Concerning concern VBG cord-006856-b1w25ob5 622 2 genotype genotype NN cord-006856-b1w25ob5 622 3 , , , cord-006856-b1w25ob5 622 4 CMV CMV NNP cord-006856-b1w25ob5 622 5 status status NN cord-006856-b1w25ob5 622 6 , , , cord-006856-b1w25ob5 622 7 presence presence NN cord-006856-b1w25ob5 622 8 of of IN cord-006856-b1w25ob5 622 9 HCC HCC NNP cord-006856-b1w25ob5 622 10 before before IN cord-006856-b1w25ob5 622 11 LT LT NNP cord-006856-b1w25ob5 622 12 , , , cord-006856-b1w25ob5 622 13 rejection rejection NN cord-006856-b1w25ob5 622 14 episodes episode NNS cord-006856-b1w25ob5 622 15 , , , cord-006856-b1w25ob5 622 16 immunosuppression immunosuppression NN cord-006856-b1w25ob5 622 17 , , , cord-006856-b1w25ob5 622 18 donor donor NN cord-006856-b1w25ob5 622 19 and and CC cord-006856-b1w25ob5 622 20 recipient recipient NN cord-006856-b1w25ob5 622 21 age age NN cord-006856-b1w25ob5 622 22 only only RB cord-006856-b1w25ob5 622 23 immunosuppression immunosuppression NN cord-006856-b1w25ob5 622 24 had have VBD cord-006856-b1w25ob5 622 25 a a DT cord-006856-b1w25ob5 622 26 significant significant JJ cord-006856-b1w25ob5 622 27 effect effect NN cord-006856-b1w25ob5 622 28 on on IN cord-006856-b1w25ob5 622 29 survival survival NN cord-006856-b1w25ob5 622 30 . . . cord-006856-b1w25ob5 623 1 In in IN cord-006856-b1w25ob5 623 2 cyclosporine cyclosporine NN cord-006856-b1w25ob5 623 3 - - HYPH cord-006856-b1w25ob5 623 4 treated treat VBN cord-006856-b1w25ob5 623 5 patients patient NNS cord-006856-b1w25ob5 623 6 ( ( -LRB- cord-006856-b1w25ob5 623 7 LT LT NNP cord-006856-b1w25ob5 623 8 after after IN cord-006856-b1w25ob5 623 9 1995 1995 CD cord-006856-b1w25ob5 623 10 ) ) -RRB- cord-006856-b1w25ob5 624 1 1- 1- LS cord-006856-b1w25ob5 624 2 , , , cord-006856-b1w25ob5 625 1 2- 2- LS cord-006856-b1w25ob5 625 2 , , , cord-006856-b1w25ob5 625 3 and and CC cord-006856-b1w25ob5 625 4 5-year 5-year CD cord-006856-b1w25ob5 625 5 survival survival NN cord-006856-b1w25ob5 625 6 rates rate NNS cord-006856-b1w25ob5 625 7 were be VBD cord-006856-b1w25ob5 625 8 79 79 CD cord-006856-b1w25ob5 625 9 % % NN cord-006856-b1w25ob5 625 10 , , , cord-006856-b1w25ob5 625 11 72 72 CD cord-006856-b1w25ob5 625 12 % % NN cord-006856-b1w25ob5 625 13 , , , cord-006856-b1w25ob5 625 14 64 64 CD cord-006856-b1w25ob5 625 15 % % NN cord-006856-b1w25ob5 625 16 compared compare VBN cord-006856-b1w25ob5 625 17 to to IN cord-006856-b1w25ob5 625 18 93 93 CD cord-006856-b1w25ob5 625 19 % % NN cord-006856-b1w25ob5 625 20 , , , cord-006856-b1w25ob5 625 21 91 91 CD cord-006856-b1w25ob5 625 22 % % NN cord-006856-b1w25ob5 625 23 , , , cord-006856-b1w25ob5 625 24 77 77 CD cord-006856-b1w25ob5 625 25 % % NN cord-006856-b1w25ob5 625 26 , , , cord-006856-b1w25ob5 625 27 respectively respectively RB cord-006856-b1w25ob5 625 28 , , , cord-006856-b1w25ob5 625 29 for for IN cord-006856-b1w25ob5 625 30 tacrolimus tacrolimus NN cord-006856-b1w25ob5 625 31 - - HYPH cord-006856-b1w25ob5 625 32 based base VBN cord-006856-b1w25ob5 625 33 regimens regimen NNS cord-006856-b1w25ob5 625 34 ( ( -LRB- cord-006856-b1w25ob5 625 35 P p NN cord-006856-b1w25ob5 625 36 = = SYM cord-006856-b1w25ob5 625 37 0.04 0.04 CD cord-006856-b1w25ob5 625 38 , , , cord-006856-b1w25ob5 625 39 log log NN cord-006856-b1w25ob5 625 40 rank rank NN cord-006856-b1w25ob5 625 41 test test NN cord-006856-b1w25ob5 625 42 ) ) -RRB- cord-006856-b1w25ob5 625 43 . . . cord-006856-b1w25ob5 626 1 Conclusions conclusion NNS cord-006856-b1w25ob5 626 2 . . . cord-006856-b1w25ob5 627 1 On on IN cord-006856-b1w25ob5 627 2 the the DT cord-006856-b1w25ob5 627 3 basis basis NN cord-006856-b1w25ob5 627 4 of of IN cord-006856-b1w25ob5 627 5 our -PRON- PRP$ cord-006856-b1w25ob5 627 6 data datum NNS cord-006856-b1w25ob5 627 7 , , , cord-006856-b1w25ob5 627 8 the the DT cord-006856-b1w25ob5 627 9 overall overall JJ cord-006856-b1w25ob5 627 10 survival survival NN cord-006856-b1w25ob5 627 11 of of IN cord-006856-b1w25ob5 627 12 HCV HCV NNP cord-006856-b1w25ob5 627 13 transplanted transplant VBD cord-006856-b1w25ob5 627 14 patients patient NNS cord-006856-b1w25ob5 627 15 were be VBD cord-006856-b1w25ob5 627 16 similiar similiar JJ cord-006856-b1w25ob5 627 17 to to IN cord-006856-b1w25ob5 627 18 other other JJ cord-006856-b1w25ob5 627 19 indications indication NNS cord-006856-b1w25ob5 627 20 . . . cord-006856-b1w25ob5 628 1 Recurrent recurrent JJ cord-006856-b1w25ob5 628 2 HCV HCV NNP cord-006856-b1w25ob5 628 3 infection infection NN cord-006856-b1w25ob5 628 4 did do VBD cord-006856-b1w25ob5 628 5 not not RB cord-006856-b1w25ob5 628 6 influence influence VB cord-006856-b1w25ob5 628 7 patient patient NN cord-006856-b1w25ob5 628 8 and and CC cord-006856-b1w25ob5 628 9 graft graft NN cord-006856-b1w25ob5 628 10 survival survival NN cord-006856-b1w25ob5 628 11 . . . cord-006856-b1w25ob5 629 1 Immunosuppression Immunosuppression NNP cord-006856-b1w25ob5 629 2 may may MD cord-006856-b1w25ob5 629 3 have have VB cord-006856-b1w25ob5 629 4 an an DT cord-006856-b1w25ob5 629 5 impact impact NN cord-006856-b1w25ob5 629 6 on on IN cord-006856-b1w25ob5 629 7 survival survival NN cord-006856-b1w25ob5 629 8 in in IN cord-006856-b1w25ob5 629 9 HCV HCV NNP cord-006856-b1w25ob5 629 10 - - HYPH cord-006856-b1w25ob5 629 11 positive positive JJ cord-006856-b1w25ob5 629 12 recipients recipient NNS cord-006856-b1w25ob5 629 13 , , , cord-006856-b1w25ob5 629 14 but but CC cord-006856-b1w25ob5 629 15 optimal optimal JJ cord-006856-b1w25ob5 629 16 regimens regimen NNS cord-006856-b1w25ob5 629 17 need need VBP cord-006856-b1w25ob5 629 18 to to TO cord-006856-b1w25ob5 629 19 be be VB cord-006856-b1w25ob5 629 20 better well RBR cord-006856-b1w25ob5 629 21 defined define VBN cord-006856-b1w25ob5 629 22 by by IN cord-006856-b1w25ob5 629 23 prospective prospective JJ cord-006856-b1w25ob5 629 24 studies study NNS cord-006856-b1w25ob5 629 25 . . . cord-006856-b1w25ob5 630 1 The the DT cord-006856-b1w25ob5 630 2 advent advent NN cord-006856-b1w25ob5 630 3 of of IN cord-006856-b1w25ob5 630 4 highly highly RB cord-006856-b1w25ob5 630 5 sensitive sensitive JJ cord-006856-b1w25ob5 630 6 molecular molecular JJ cord-006856-b1w25ob5 630 7 techniques technique NNS cord-006856-b1w25ob5 630 8 has have VBZ cord-006856-b1w25ob5 630 9 revealed reveal VBN cord-006856-b1w25ob5 630 10 the the DT cord-006856-b1w25ob5 630 11 possible possible JJ cord-006856-b1w25ob5 630 12 persistence persistence NN cord-006856-b1w25ob5 630 13 of of IN cord-006856-b1w25ob5 630 14 hepatitis hepatitis NN cord-006856-b1w25ob5 630 15 B B NNP cord-006856-b1w25ob5 630 16 virus virus NN cord-006856-b1w25ob5 630 17 ( ( -LRB- cord-006856-b1w25ob5 630 18 HBV HBV NNP cord-006856-b1w25ob5 630 19 ) ) -RRB- cord-006856-b1w25ob5 630 20 genomes genome NNS cord-006856-b1w25ob5 630 21 in in IN cord-006856-b1w25ob5 630 22 HBsAg hbsag CD cord-006856-b1w25ob5 630 23 - - HYPH cord-006856-b1w25ob5 630 24 negative negative JJ cord-006856-b1w25ob5 630 25 patients patient NNS cord-006856-b1w25ob5 630 26 with with IN cord-006856-b1w25ob5 630 27 or or CC cord-006856-b1w25ob5 630 28 without without IN cord-006856-b1w25ob5 630 29 serologic serologic JJ cord-006856-b1w25ob5 630 30 markers marker NNS cord-006856-b1w25ob5 630 31 of of IN cord-006856-b1w25ob5 630 32 previous previous JJ cord-006856-b1w25ob5 630 33 infection infection NN cord-006856-b1w25ob5 630 34 , , , cord-006856-b1w25ob5 630 35 a a DT cord-006856-b1w25ob5 630 36 state state NN cord-006856-b1w25ob5 630 37 called call VBN cord-006856-b1w25ob5 630 38 occult occult JJ cord-006856-b1w25ob5 630 39 HBV HBV NNP cord-006856-b1w25ob5 630 40 infection infection NN cord-006856-b1w25ob5 630 41 . . . cord-006856-b1w25ob5 631 1 The the DT cord-006856-b1w25ob5 631 2 highest high JJS cord-006856-b1w25ob5 631 3 prevalence prevalence NN cord-006856-b1w25ob5 631 4 of of IN cord-006856-b1w25ob5 631 5 such such JJ cord-006856-b1w25ob5 631 6 infection infection NN cord-006856-b1w25ob5 631 7 has have VBZ cord-006856-b1w25ob5 631 8 been be VBN cord-006856-b1w25ob5 631 9 shown show VBN cord-006856-b1w25ob5 631 10 in in IN cord-006856-b1w25ob5 631 11 patients patient NNS cord-006856-b1w25ob5 631 12 infected infect VBN cord-006856-b1w25ob5 631 13 with with IN cord-006856-b1w25ob5 631 14 hepatitis hepatitis NN cord-006856-b1w25ob5 631 15 C C NNP cord-006856-b1w25ob5 631 16 virus virus NN cord-006856-b1w25ob5 631 17 ( ( -LRB- cord-006856-b1w25ob5 631 18 HCV HCV NNP cord-006856-b1w25ob5 631 19 ) ) -RRB- cord-006856-b1w25ob5 631 20 . . . cord-006856-b1w25ob5 632 1 Some some DT cord-006856-b1w25ob5 632 2 studies study NNS cord-006856-b1w25ob5 632 3 suggested suggest VBD cord-006856-b1w25ob5 632 4 that that IN cord-006856-b1w25ob5 632 5 occult occult JJ cord-006856-b1w25ob5 632 6 HBV HBV NNP cord-006856-b1w25ob5 632 7 infection infection NN cord-006856-b1w25ob5 632 8 might may MD cord-006856-b1w25ob5 632 9 favor favor VB cord-006856-b1w25ob5 632 10 or or CC cord-006856-b1w25ob5 632 11 accelerate accelerate VB cord-006856-b1w25ob5 632 12 the the DT cord-006856-b1w25ob5 632 13 progression progression NN cord-006856-b1w25ob5 632 14 of of IN cord-006856-b1w25ob5 632 15 HCV HCV NNP cord-006856-b1w25ob5 632 16 infection infection NN cord-006856-b1w25ob5 632 17 towards towards IN cord-006856-b1w25ob5 632 18 cirrhosis cirrhosis NN cord-006856-b1w25ob5 632 19 . . . cord-006856-b1w25ob5 633 1 HCV HCV NNP cord-006856-b1w25ob5 633 2 infection infection NN cord-006856-b1w25ob5 633 3 recurs recur VBZ cord-006856-b1w25ob5 633 4 almost almost RB cord-006856-b1w25ob5 633 5 in in IN cord-006856-b1w25ob5 633 6 all all DT cord-006856-b1w25ob5 633 7 patients patient NNS cord-006856-b1w25ob5 633 8 after after IN cord-006856-b1w25ob5 633 9 liver liver NN cord-006856-b1w25ob5 633 10 transplantation transplantation NN cord-006856-b1w25ob5 633 11 ( ( -LRB- cord-006856-b1w25ob5 633 12 LT LT NNP cord-006856-b1w25ob5 633 13 ) ) -RRB- cord-006856-b1w25ob5 633 14 . . . cord-006856-b1w25ob5 634 1 About about RB cord-006856-b1w25ob5 634 2 5 5 CD cord-006856-b1w25ob5 634 3 - - SYM cord-006856-b1w25ob5 634 4 10 10 CD cord-006856-b1w25ob5 634 5 % % NN cord-006856-b1w25ob5 634 6 of of IN cord-006856-b1w25ob5 634 7 LT LT NNP cord-006856-b1w25ob5 634 8 patients patient NNS cord-006856-b1w25ob5 634 9 develop develop VBP cord-006856-b1w25ob5 634 10 a a DT cord-006856-b1w25ob5 634 11 fibrosing fibrose VBG cord-006856-b1w25ob5 634 12 cholestatic cholestatic VBN cord-006856-b1w25ob5 634 13 HCV HCV NNP cord-006856-b1w25ob5 634 14 recurrence recurrence NN cord-006856-b1w25ob5 634 15 , , , cord-006856-b1w25ob5 634 16 which which WDT cord-006856-b1w25ob5 634 17 is be VBZ cord-006856-b1w25ob5 634 18 associated associate VBN cord-006856-b1w25ob5 634 19 with with IN cord-006856-b1w25ob5 634 20 a a DT cord-006856-b1w25ob5 634 21 very very RB cord-006856-b1w25ob5 634 22 poor poor JJ cord-006856-b1w25ob5 634 23 outcome outcome NN cord-006856-b1w25ob5 634 24 . . . cord-006856-b1w25ob5 635 1 No no DT cord-006856-b1w25ob5 635 2 specific specific JJ cord-006856-b1w25ob5 635 3 risk risk NN cord-006856-b1w25ob5 635 4 factor factor NN cord-006856-b1w25ob5 635 5 for for IN cord-006856-b1w25ob5 635 6 this this DT cord-006856-b1w25ob5 635 7 pattern pattern NN cord-006856-b1w25ob5 635 8 of of IN cord-006856-b1w25ob5 635 9 recurrence recurrence NN cord-006856-b1w25ob5 635 10 has have VBZ cord-006856-b1w25ob5 635 11 been be VBN cord-006856-b1w25ob5 635 12 described describe VBN cord-006856-b1w25ob5 635 13 so so RB cord-006856-b1w25ob5 635 14 far far RB cord-006856-b1w25ob5 635 15 . . . cord-006856-b1w25ob5 636 1 The the DT cord-006856-b1w25ob5 636 2 aim aim NN cord-006856-b1w25ob5 636 3 of of IN cord-006856-b1w25ob5 636 4 this this DT cord-006856-b1w25ob5 636 5 study study NN cord-006856-b1w25ob5 636 6 was be VBD cord-006856-b1w25ob5 636 7 to to TO cord-006856-b1w25ob5 636 8 determine determine VB cord-006856-b1w25ob5 636 9 the the DT cord-006856-b1w25ob5 636 10 prevalence prevalence NN cord-006856-b1w25ob5 636 11 of of IN cord-006856-b1w25ob5 636 12 occult occult JJ cord-006856-b1w25ob5 636 13 HBV HBV NNP cord-006856-b1w25ob5 636 14 infection infection NN cord-006856-b1w25ob5 636 15 in in IN cord-006856-b1w25ob5 636 16 patients patient NNS cord-006856-b1w25ob5 636 17 presenting present VBG cord-006856-b1w25ob5 636 18 with with IN cord-006856-b1w25ob5 636 19 fibrosing fibrose VBG cord-006856-b1w25ob5 636 20 cholestatic cholestatic JJ cord-006856-b1w25ob5 636 21 HCV HCV NNP cord-006856-b1w25ob5 636 22 recurrence recurrence NN cord-006856-b1w25ob5 636 23 after after IN cord-006856-b1w25ob5 636 24 LT LT NNP cord-006856-b1w25ob5 636 25 . . . cord-006856-b1w25ob5 637 1 Between between IN cord-006856-b1w25ob5 637 2 1986 1986 CD cord-006856-b1w25ob5 637 3 and and CC cord-006856-b1w25ob5 637 4 2004 2004 CD cord-006856-b1w25ob5 637 5 , , , cord-006856-b1w25ob5 637 6 151 151 CD cord-006856-b1w25ob5 637 7 HCV HCV NNP cord-006856-b1w25ob5 637 8 patients patient NNS cord-006856-b1w25ob5 637 9 ( ( -LRB- cord-006856-b1w25ob5 637 10 104 104 CD cord-006856-b1w25ob5 637 11 m m NN cord-006856-b1w25ob5 637 12 ; ; : cord-006856-b1w25ob5 637 13 47 47 CD cord-006856-b1w25ob5 637 14 f f NNP cord-006856-b1w25ob5 637 15 ) ) -RRB- cord-006856-b1w25ob5 637 16 underwent undergo VBD cord-006856-b1w25ob5 637 17 LT LT NNP cord-006856-b1w25ob5 637 18 at at IN cord-006856-b1w25ob5 637 19 our -PRON- PRP$ cord-006856-b1w25ob5 637 20 institution institution NN cord-006856-b1w25ob5 637 21 . . . cord-006856-b1w25ob5 638 1 The the DT cord-006856-b1w25ob5 638 2 mean mean JJ cord-006856-b1w25ob5 638 3 follow follow NN cord-006856-b1w25ob5 638 4 - - HYPH cord-006856-b1w25ob5 638 5 up up NN cord-006856-b1w25ob5 638 6 was be VBD cord-006856-b1w25ob5 638 7 51 51 CD cord-006856-b1w25ob5 638 8 months month NNS cord-006856-b1w25ob5 639 1 ( ( -LRB- cord-006856-b1w25ob5 639 2 range range NN cord-006856-b1w25ob5 639 3 , , , cord-006856-b1w25ob5 639 4 1 1 CD cord-006856-b1w25ob5 639 5 - - SYM cord-006856-b1w25ob5 639 6 228 228 CD cord-006856-b1w25ob5 639 7 months month NNS cord-006856-b1w25ob5 639 8 ) ) -RRB- cord-006856-b1w25ob5 639 9 . . . cord-006856-b1w25ob5 640 1 The the DT cord-006856-b1w25ob5 640 2 diagnosis diagnosis NN cord-006856-b1w25ob5 640 3 of of IN cord-006856-b1w25ob5 640 4 recurrence recurrence NN cord-006856-b1w25ob5 640 5 was be VBD cord-006856-b1w25ob5 640 6 based base VBN cord-006856-b1w25ob5 640 7 on on IN cord-006856-b1w25ob5 640 8 biochemical biochemical JJ cord-006856-b1w25ob5 640 9 and and CC cord-006856-b1w25ob5 640 10 histologic histologic JJ cord-006856-b1w25ob5 640 11 parameters parameter NNS cord-006856-b1w25ob5 640 12 . . . cord-006856-b1w25ob5 641 1 Genotype genotype NN cord-006856-b1w25ob5 641 2 1 1 CD cord-006856-b1w25ob5 641 3 was be VBD cord-006856-b1w25ob5 641 4 predominant predominant JJ cord-006856-b1w25ob5 641 5 ( ( -LRB- cord-006856-b1w25ob5 641 6 75 75 CD cord-006856-b1w25ob5 641 7 % % NN cord-006856-b1w25ob5 641 8 ) ) -RRB- cord-006856-b1w25ob5 641 9 , , , cord-006856-b1w25ob5 641 10 followed follow VBN cord-006856-b1w25ob5 641 11 by by IN cord-006856-b1w25ob5 641 12 2 2 CD cord-006856-b1w25ob5 641 13 ( ( -LRB- cord-006856-b1w25ob5 641 14 15 15 CD cord-006856-b1w25ob5 641 15 % % NN cord-006856-b1w25ob5 641 16 ) ) -RRB- cord-006856-b1w25ob5 641 17 , , , cord-006856-b1w25ob5 641 18 3 3 CD cord-006856-b1w25ob5 641 19 ( ( -LRB- cord-006856-b1w25ob5 641 20 8 8 CD cord-006856-b1w25ob5 641 21 % % NN cord-006856-b1w25ob5 641 22 ) ) -RRB- cord-006856-b1w25ob5 641 23 , , , cord-006856-b1w25ob5 641 24 and and CC cord-006856-b1w25ob5 641 25 4 4 CD cord-006856-b1w25ob5 641 26 ( ( -LRB- cord-006856-b1w25ob5 641 27 3 3 CD cord-006856-b1w25ob5 641 28 % % NN cord-006856-b1w25ob5 641 29 ) ) -RRB- cord-006856-b1w25ob5 641 30 . . . cord-006856-b1w25ob5 642 1 Eleven eleven CD cord-006856-b1w25ob5 642 2 patients patient NNS cord-006856-b1w25ob5 642 3 ( ( -LRB- cord-006856-b1w25ob5 642 4 7.3 7.3 CD cord-006856-b1w25ob5 642 5 % % NN cord-006856-b1w25ob5 642 6 ; ; : cord-006856-b1w25ob5 642 7 10 10 CD cord-006856-b1w25ob5 642 8 m m NN cord-006856-b1w25ob5 642 9 , , , cord-006856-b1w25ob5 642 10 1 1 CD cord-006856-b1w25ob5 642 11 f f NNP cord-006856-b1w25ob5 642 12 ) ) -RRB- cord-006856-b1w25ob5 642 13 developed develop VBD cord-006856-b1w25ob5 642 14 a a DT cord-006856-b1w25ob5 642 15 fibrosing fibrose VBG cord-006856-b1w25ob5 642 16 cholestatic cholestatic JJ cord-006856-b1w25ob5 642 17 pattern pattern NN cord-006856-b1w25ob5 642 18 of of IN cord-006856-b1w25ob5 642 19 recurrence recurrence NN cord-006856-b1w25ob5 642 20 characterized characterize VBN cord-006856-b1w25ob5 642 21 by by IN cord-006856-b1w25ob5 642 22 highly highly RB cord-006856-b1w25ob5 642 23 elevated elevate VBN cord-006856-b1w25ob5 642 24 cholestatic cholestatic JJ cord-006856-b1w25ob5 642 25 parameters parameter NNS cord-006856-b1w25ob5 642 26 and and CC cord-006856-b1w25ob5 642 27 typical typical JJ cord-006856-b1w25ob5 642 28 histologic histologic JJ cord-006856-b1w25ob5 642 29 findings finding NNS cord-006856-b1w25ob5 642 30 . . . cord-006856-b1w25ob5 643 1 Also also RB cord-006856-b1w25ob5 643 2 in in IN cord-006856-b1w25ob5 643 3 this this DT cord-006856-b1w25ob5 643 4 group group NN cord-006856-b1w25ob5 643 5 , , , cord-006856-b1w25ob5 643 6 genotype genotype NN cord-006856-b1w25ob5 643 7 1 1 CD cord-006856-b1w25ob5 643 8 was be VBD cord-006856-b1w25ob5 643 9 predominant predominant JJ cord-006856-b1w25ob5 643 10 ( ( -LRB- cord-006856-b1w25ob5 643 11 N n NN cord-006856-b1w25ob5 643 12 = = SYM cord-006856-b1w25ob5 643 13 7 7 CD cord-006856-b1w25ob5 643 14 ) ) -RRB- cord-006856-b1w25ob5 643 15 , , , cord-006856-b1w25ob5 643 16 three three CD cord-006856-b1w25ob5 643 17 had have VBD cord-006856-b1w25ob5 643 18 type type NN cord-006856-b1w25ob5 643 19 3 3 CD cord-006856-b1w25ob5 643 20 , , , cord-006856-b1w25ob5 643 21 and and CC cord-006856-b1w25ob5 643 22 one one CD cord-006856-b1w25ob5 643 23 type type NN cord-006856-b1w25ob5 643 24 4 4 CD cord-006856-b1w25ob5 643 25 . . . cord-006856-b1w25ob5 644 1 Serum serum NN cord-006856-b1w25ob5 644 2 HBV HBV NNP cord-006856-b1w25ob5 644 3 DNA DNA NNP cord-006856-b1w25ob5 644 4 was be VBD cord-006856-b1w25ob5 644 5 tested test VBN cord-006856-b1w25ob5 644 6 with with IN cord-006856-b1w25ob5 644 7 the the DT cord-006856-b1w25ob5 644 8 TaqMan TaqMan NNP cord-006856-b1w25ob5 644 9 test test NN cord-006856-b1w25ob5 644 10 ( ( -LRB- cord-006856-b1w25ob5 644 11 Roche Roche NNP cord-006856-b1w25ob5 644 12 , , , cord-006856-b1w25ob5 644 13 Austria Austria NNP cord-006856-b1w25ob5 644 14 ) ) -RRB- cord-006856-b1w25ob5 644 15 . . . cord-006856-b1w25ob5 645 1 Five five CD cord-006856-b1w25ob5 645 2 patients patient NNS cord-006856-b1w25ob5 645 3 were be VBD cord-006856-b1w25ob5 645 4 HBsAg HBsAg NNP cord-006856-b1w25ob5 645 5 negative negative JJ cord-006856-b1w25ob5 645 6 , , , cord-006856-b1w25ob5 645 7 whereas whereas IN cord-006856-b1w25ob5 645 8 six six CD cord-006856-b1w25ob5 645 9 had have VBD cord-006856-b1w25ob5 645 10 serologic serologic JJ cord-006856-b1w25ob5 645 11 markers marker NNS cord-006856-b1w25ob5 645 12 ( ( -LRB- cord-006856-b1w25ob5 646 1 antiHBc antihbc DT cord-006856-b1w25ob5 646 2 positive positive JJ cord-006856-b1w25ob5 646 3 ) ) -RRB- cord-006856-b1w25ob5 646 4 . . . cord-006856-b1w25ob5 647 1 Interestingly interestingly RB cord-006856-b1w25ob5 647 2 , , , cord-006856-b1w25ob5 647 3 HBV HBV NNP cord-006856-b1w25ob5 647 4 DNA DNA NNP cord-006856-b1w25ob5 647 5 could could MD cord-006856-b1w25ob5 647 6 not not RB cord-006856-b1w25ob5 647 7 be be VB cord-006856-b1w25ob5 647 8 detected detect VBN cord-006856-b1w25ob5 647 9 in in IN cord-006856-b1w25ob5 647 10 the the DT cord-006856-b1w25ob5 647 11 sera sera NNP cord-006856-b1w25ob5 647 12 of of IN cord-006856-b1w25ob5 647 13 any any DT cord-006856-b1w25ob5 647 14 of of IN cord-006856-b1w25ob5 647 15 these these DT cord-006856-b1w25ob5 647 16 patients patient NNS cord-006856-b1w25ob5 647 17 with with IN cord-006856-b1w25ob5 647 18 fibrosing fibrose VBG cord-006856-b1w25ob5 647 19 cholestatic cholestatic JJ cord-006856-b1w25ob5 647 20 HCV HCV NNP cord-006856-b1w25ob5 647 21 recurrence recurrence NN cord-006856-b1w25ob5 647 22 . . . cord-006856-b1w25ob5 648 1 The the DT cord-006856-b1w25ob5 648 2 actuarial actuarial JJ cord-006856-b1w25ob5 648 3 1- 1- NNP cord-006856-b1w25ob5 648 4 , , , cord-006856-b1w25ob5 648 5 2- 2- LS cord-006856-b1w25ob5 648 6 , , , cord-006856-b1w25ob5 648 7 5- 5- NNP cord-006856-b1w25ob5 648 8 , , , cord-006856-b1w25ob5 648 9 and and CC cord-006856-b1w25ob5 648 10 10-year 10-year CD cord-006856-b1w25ob5 648 11 survival survival NN cord-006856-b1w25ob5 648 12 rates rate NNS cord-006856-b1w25ob5 648 13 of of IN cord-006856-b1w25ob5 648 14 all all DT cord-006856-b1w25ob5 648 15 HCV HCV NNP cord-006856-b1w25ob5 648 16 patients patient NNS cord-006856-b1w25ob5 648 17 were be VBD cord-006856-b1w25ob5 648 18 83 83 CD cord-006856-b1w25ob5 648 19 % % NN cord-006856-b1w25ob5 648 20 , , , cord-006856-b1w25ob5 648 21 79 79 CD cord-006856-b1w25ob5 648 22 % % NN cord-006856-b1w25ob5 648 23 , , , cord-006856-b1w25ob5 648 24 68 68 CD cord-006856-b1w25ob5 648 25 % % NN cord-006856-b1w25ob5 648 26 , , , cord-006856-b1w25ob5 648 27 and and CC cord-006856-b1w25ob5 648 28 60 60 CD cord-006856-b1w25ob5 648 29 % % NN cord-006856-b1w25ob5 648 30 . . . cord-006856-b1w25ob5 649 1 HCV HCV NNP cord-006856-b1w25ob5 649 2 recurrence recurrence NN cord-006856-b1w25ob5 649 3 did do VBD cord-006856-b1w25ob5 649 4 not not RB cord-006856-b1w25ob5 649 5 show show VB cord-006856-b1w25ob5 649 6 a a DT cord-006856-b1w25ob5 649 7 negative negative JJ cord-006856-b1w25ob5 649 8 impact impact NN cord-006856-b1w25ob5 649 9 on on IN cord-006856-b1w25ob5 649 10 patient patient NN cord-006856-b1w25ob5 649 11 and and CC cord-006856-b1w25ob5 649 12 graft graft NN cord-006856-b1w25ob5 649 13 survival survival NN cord-006856-b1w25ob5 649 14 ; ; : cord-006856-b1w25ob5 649 15 however however RB cord-006856-b1w25ob5 649 16 , , , cord-006856-b1w25ob5 649 17 the the DT cord-006856-b1w25ob5 649 18 outcome outcome NN cord-006856-b1w25ob5 649 19 of of IN cord-006856-b1w25ob5 649 20 the the DT cord-006856-b1w25ob5 649 21 patients patient NNS cord-006856-b1w25ob5 649 22 with with IN cord-006856-b1w25ob5 649 23 the the DT cord-006856-b1w25ob5 649 24 fibrosing fibrose VBG cord-006856-b1w25ob5 649 25 cholestatic cholestatic NN cord-006856-b1w25ob5 649 26 pattern pattern NN cord-006856-b1w25ob5 649 27 was be VBD cord-006856-b1w25ob5 649 28 less less RBR cord-006856-b1w25ob5 649 29 favorable favorable JJ cord-006856-b1w25ob5 649 30 . . . cord-006856-b1w25ob5 650 1 Seven seven CD cord-006856-b1w25ob5 650 2 out out IN cord-006856-b1w25ob5 650 3 of of IN cord-006856-b1w25ob5 650 4 11 11 CD cord-006856-b1w25ob5 650 5 patients patient NNS cord-006856-b1w25ob5 650 6 died die VBD cord-006856-b1w25ob5 650 7 due due IN cord-006856-b1w25ob5 650 8 to to IN cord-006856-b1w25ob5 650 9 HCV HCV NNP cord-006856-b1w25ob5 650 10 recurrence recurrence NN cord-006856-b1w25ob5 650 11 , , , cord-006856-b1w25ob5 650 12 one one CD cord-006856-b1w25ob5 650 13 patient patient NN cord-006856-b1w25ob5 650 14 had have VBD cord-006856-b1w25ob5 650 15 to to TO cord-006856-b1w25ob5 650 16 be be VB cord-006856-b1w25ob5 650 17 retransplanted retransplante VBN cord-006856-b1w25ob5 650 18 secondary secondary JJ cord-006856-b1w25ob5 650 19 to to IN cord-006856-b1w25ob5 650 20 recurrent recurrent JJ cord-006856-b1w25ob5 650 21 disease disease NN cord-006856-b1w25ob5 650 22 . . . cord-006856-b1w25ob5 651 1 Only only RB cord-006856-b1w25ob5 651 2 three three CD cord-006856-b1w25ob5 651 3 patients patient NNS cord-006856-b1w25ob5 651 4 are be VBP cord-006856-b1w25ob5 651 5 alive alive JJ cord-006856-b1w25ob5 651 6 with with IN cord-006856-b1w25ob5 651 7 a a DT cord-006856-b1w25ob5 651 8 functioning function VBG cord-006856-b1w25ob5 651 9 first first JJ cord-006856-b1w25ob5 651 10 allograft allograft NN cord-006856-b1w25ob5 651 11 . . . cord-006856-b1w25ob5 652 1 This this DT cord-006856-b1w25ob5 652 2 study study NN cord-006856-b1w25ob5 652 3 indicates indicate VBZ cord-006856-b1w25ob5 652 4 that that IN cord-006856-b1w25ob5 652 5 occult occult JJ cord-006856-b1w25ob5 652 6 HBV HBV NNP cord-006856-b1w25ob5 652 7 infection infection NN cord-006856-b1w25ob5 652 8 is be VBZ cord-006856-b1w25ob5 652 9 not not RB cord-006856-b1w25ob5 652 10 associated associate VBN cord-006856-b1w25ob5 652 11 with with IN cord-006856-b1w25ob5 652 12 fibrosing fibrose VBG cord-006856-b1w25ob5 652 13 cholestatic cholestatic NNP cord-006856-b1w25ob5 652 14 hepatitis hepatitis NN cord-006856-b1w25ob5 652 15 C C NNP cord-006856-b1w25ob5 652 16 recurrence recurrence NN cord-006856-b1w25ob5 652 17 after after IN cord-006856-b1w25ob5 652 18 LT LT NNP cord-006856-b1w25ob5 652 19 . . . cord-006856-b1w25ob5 653 1 Background background NN cord-006856-b1w25ob5 653 2 . . . cord-006856-b1w25ob5 654 1 The the DT cord-006856-b1w25ob5 654 2 use use NN cord-006856-b1w25ob5 654 3 of of IN cord-006856-b1w25ob5 654 4 grafts graft NNS cord-006856-b1w25ob5 654 5 from from IN cord-006856-b1w25ob5 654 6 hepatitis hepatitis NNP cord-006856-b1w25ob5 654 7 B B NNP cord-006856-b1w25ob5 654 8 core core NN cord-006856-b1w25ob5 654 9 antibody antibody NN cord-006856-b1w25ob5 654 10 ( ( -LRB- cord-006856-b1w25ob5 654 11 anti anti JJ cord-006856-b1w25ob5 654 12 - - JJ cord-006856-b1w25ob5 654 13 HBcAB)-positive hbcab)-positive JJ cord-006856-b1w25ob5 654 14 donors donor NNS cord-006856-b1w25ob5 654 15 for for IN cord-006856-b1w25ob5 654 16 liver liver NN cord-006856-b1w25ob5 654 17 transplantation transplantation NN cord-006856-b1w25ob5 654 18 ( ( -LRB- cord-006856-b1w25ob5 654 19 LT LT NNP cord-006856-b1w25ob5 654 20 ) ) -RRB- cord-006856-b1w25ob5 654 21 is be VBZ cord-006856-b1w25ob5 654 22 associated associate VBN cord-006856-b1w25ob5 654 23 with with IN cord-006856-b1w25ob5 654 24 the the DT cord-006856-b1w25ob5 654 25 risk risk NN cord-006856-b1w25ob5 654 26 of of IN cord-006856-b1w25ob5 654 27 de de NNP cord-006856-b1w25ob5 654 28 novo novo NNP cord-006856-b1w25ob5 654 29 hepatitis hepatitis NNP cord-006856-b1w25ob5 654 30 B. B. NNP cord-006856-b1w25ob5 654 31 Patients Patients NNP cord-006856-b1w25ob5 654 32 who who WP cord-006856-b1w25ob5 654 33 test test VBP cord-006856-b1w25ob5 654 34 positive positive JJ cord-006856-b1w25ob5 654 35 for for IN cord-006856-b1w25ob5 654 36 anti anti JJ cord-006856-b1w25ob5 654 37 - - JJ cord-006856-b1w25ob5 654 38 HBcAB hbcab JJ cord-006856-b1w25ob5 654 39 pretransplant pretransplant NN cord-006856-b1w25ob5 654 40 are be VBP cord-006856-b1w25ob5 654 41 also also RB cord-006856-b1w25ob5 654 42 theoretically theoretically RB cord-006856-b1w25ob5 654 43 at at IN cord-006856-b1w25ob5 654 44 risk risk NN cord-006856-b1w25ob5 654 45 to to TO cord-006856-b1w25ob5 654 46 develop develop VB cord-006856-b1w25ob5 654 47 graft graft NN cord-006856-b1w25ob5 654 48 hepatitis hepatitis NN cord-006856-b1w25ob5 654 49 B. B. NNP cord-006856-b1w25ob5 654 50 Methods Methods NNPS cord-006856-b1w25ob5 654 51 . . . cord-006856-b1w25ob5 655 1 The the DT cord-006856-b1w25ob5 655 2 outcome outcome NN cord-006856-b1w25ob5 655 3 of of IN cord-006856-b1w25ob5 655 4 467 467 CD cord-006856-b1w25ob5 655 5 consecutive consecutive JJ cord-006856-b1w25ob5 655 6 LTs lt NNS cord-006856-b1w25ob5 655 7 performed perform VBN cord-006856-b1w25ob5 655 8 in in IN cord-006856-b1w25ob5 655 9 402 402 CD cord-006856-b1w25ob5 655 10 individuals individual NNS cord-006856-b1w25ob5 655 11 between between IN cord-006856-b1w25ob5 655 12 1998 1998 CD cord-006856-b1w25ob5 655 13 and and CC cord-006856-b1w25ob5 655 14 2001 2001 CD cord-006856-b1w25ob5 655 15 was be VBD cord-006856-b1w25ob5 655 16 retrospectively retrospectively RB cord-006856-b1w25ob5 655 17 analyzed analyze VBN cord-006856-b1w25ob5 655 18 with with IN cord-006856-b1w25ob5 655 19 regard regard NN cord-006856-b1w25ob5 655 20 to to IN cord-006856-b1w25ob5 655 21 the the DT cord-006856-b1w25ob5 655 22 presence presence NN cord-006856-b1w25ob5 655 23 of of IN cord-006856-b1w25ob5 655 24 anti anti JJ cord-006856-b1w25ob5 655 25 - - JJ cord-006856-b1w25ob5 655 26 HBcAB hbcab JJ cord-006856-b1w25ob5 655 27 in in IN cord-006856-b1w25ob5 655 28 donors donor NNS cord-006856-b1w25ob5 655 29 and and CC cord-006856-b1w25ob5 655 30 recipients recipient NNS cord-006856-b1w25ob5 655 31 . . . cord-006856-b1w25ob5 656 1 Patients patient NNS cord-006856-b1w25ob5 656 2 with with IN cord-006856-b1w25ob5 656 3 hepatitis hepatitis NN cord-006856-b1w25ob5 656 4 B b NN cord-006856-b1w25ob5 656 5 and and CC cord-006856-b1w25ob5 656 6 recipients recipient NNS cord-006856-b1w25ob5 656 7 of of IN cord-006856-b1w25ob5 656 8 known know VBN cord-006856-b1w25ob5 656 9 anti anti JJ cord-006856-b1w25ob5 656 10 - - JJ cord-006856-b1w25ob5 656 11 HBcAB hbcab JJ cord-006856-b1w25ob5 656 12 - - HYPH cord-006856-b1w25ob5 656 13 positive positive JJ cord-006856-b1w25ob5 656 14 grafts graft NNS cord-006856-b1w25ob5 656 15 received receive VBD cord-006856-b1w25ob5 656 16 HBIg HBIg NNS cord-006856-b1w25ob5 656 17 / / SYM cord-006856-b1w25ob5 656 18 Lamivudine Lamivudine NNP cord-006856-b1w25ob5 656 19 prophylaxis prophylaxis NN cord-006856-b1w25ob5 656 20 . . . cord-006856-b1w25ob5 657 1 Results result NNS cord-006856-b1w25ob5 657 2 . . . cord-006856-b1w25ob5 658 1 A a DT cord-006856-b1w25ob5 658 2 total total NN cord-006856-b1w25ob5 658 3 of of IN cord-006856-b1w25ob5 658 4 111 111 CD cord-006856-b1w25ob5 658 5 recipients recipient NNS cord-006856-b1w25ob5 658 6 ( ( -LRB- cord-006856-b1w25ob5 658 7 28 28 CD cord-006856-b1w25ob5 658 8 % % NN cord-006856-b1w25ob5 658 9 ) ) -RRB- cord-006856-b1w25ob5 658 10 tested test VBD cord-006856-b1w25ob5 658 11 positive positive JJ cord-006856-b1w25ob5 658 12 for for IN cord-006856-b1w25ob5 658 13 anti anti JJ cord-006856-b1w25ob5 658 14 - - JJ cord-006856-b1w25ob5 658 15 HBcAB hbcab JJ cord-006856-b1w25ob5 658 16 including include VBG cord-006856-b1w25ob5 658 17 24 24 CD cord-006856-b1w25ob5 658 18 patients patient NNS cord-006856-b1w25ob5 658 19 ( ( -LRB- cord-006856-b1w25ob5 658 20 7 7 CD cord-006856-b1w25ob5 658 21 % % NN cord-006856-b1w25ob5 658 22 ) ) -RRB- cord-006856-b1w25ob5 658 23 with with IN cord-006856-b1w25ob5 658 24 HBV HBV NNP cord-006856-b1w25ob5 658 25 - - HYPH cord-006856-b1w25ob5 658 26 associated associate VBN cord-006856-b1w25ob5 658 27 cirrhosis cirrhosis NN cord-006856-b1w25ob5 658 28 and and CC cord-006856-b1w25ob5 658 29 three three CD cord-006856-b1w25ob5 658 30 patients patient NNS cord-006856-b1w25ob5 658 31 with with IN cord-006856-b1w25ob5 658 32 fulminant fulminant JJ cord-006856-b1w25ob5 658 33 hepatitis hepatitis NN cord-006856-b1w25ob5 658 34 B. B. NNP cord-006856-b1w25ob5 658 35 A A NNP cord-006856-b1w25ob5 658 36 total total NN cord-006856-b1w25ob5 658 37 of of IN cord-006856-b1w25ob5 658 38 20 20 CD cord-006856-b1w25ob5 658 39 allografts allograft NNS cord-006856-b1w25ob5 658 40 from from IN cord-006856-b1w25ob5 658 41 anti anti JJ cord-006856-b1w25ob5 658 42 - - JJ cord-006856-b1w25ob5 658 43 HBcAB hbcab JJ cord-006856-b1w25ob5 658 44 - - HYPH cord-006856-b1w25ob5 658 45 positive positive JJ cord-006856-b1w25ob5 658 46 donors donor NNS cord-006856-b1w25ob5 658 47 were be VBD cord-006856-b1w25ob5 658 48 utilized utilize VBN cord-006856-b1w25ob5 658 49 , , , cord-006856-b1w25ob5 658 50 14 14 CD cord-006856-b1w25ob5 658 51 of of IN cord-006856-b1w25ob5 658 52 those those DT cord-006856-b1w25ob5 658 53 ( ( -LRB- cord-006856-b1w25ob5 658 54 70 70 CD cord-006856-b1w25ob5 658 55 % % NN cord-006856-b1w25ob5 658 56 ) ) -RRB- cord-006856-b1w25ob5 658 57 were be VBD cord-006856-b1w25ob5 658 58 allocated allocate VBN cord-006856-b1w25ob5 658 59 to to IN cord-006856-b1w25ob5 658 60 anti anti JJ cord-006856-b1w25ob5 658 61 - - JJ cord-006856-b1w25ob5 658 62 HBcAB hbcab JJ cord-006856-b1w25ob5 658 63 - - HYPH cord-006856-b1w25ob5 658 64 positive positive JJ cord-006856-b1w25ob5 658 65 recipients recipient NNS cord-006856-b1w25ob5 658 66 . . . cord-006856-b1w25ob5 659 1 Anti anti JJ cord-006856-b1w25ob5 659 2 - - JJ cord-006856-b1w25ob5 659 3 HBcAB hbcab JJ cord-006856-b1w25ob5 659 4 - - HYPH cord-006856-b1w25ob5 659 5 positive positive JJ cord-006856-b1w25ob5 659 6 recipients recipient NNS cord-006856-b1w25ob5 659 7 were be VBD cord-006856-b1w25ob5 659 8 significantly significantly RB cord-006856-b1w25ob5 659 9 more more RBR cord-006856-b1w25ob5 659 10 likely likely JJ cord-006856-b1w25ob5 659 11 to to TO cord-006856-b1w25ob5 659 12 have have VB cord-006856-b1w25ob5 659 13 concomitant concomitant JJ cord-006856-b1w25ob5 659 14 HCV HCV NNP cord-006856-b1w25ob5 659 15 ( ( -LRB- cord-006856-b1w25ob5 659 16 62 62 CD cord-006856-b1w25ob5 659 17 % % NN cord-006856-b1w25ob5 659 18 vs. vs. NN cord-006856-b1w25ob5 659 19 34 34 CD cord-006856-b1w25ob5 659 20 % % NN cord-006856-b1w25ob5 659 21 , , , cord-006856-b1w25ob5 659 22 P p NN cord-006856-b1w25ob5 659 23 < < XX cord-006856-b1w25ob5 659 24 0.0001 0.0001 CD cord-006856-b1w25ob5 659 25 ) ) -RRB- cord-006856-b1w25ob5 659 26 and and CC cord-006856-b1w25ob5 659 27 hepatocellular hepatocellular JJ cord-006856-b1w25ob5 659 28 carcinoma carcinoma NN cord-006856-b1w25ob5 659 29 ( ( -LRB- cord-006856-b1w25ob5 659 30 30 30 CD cord-006856-b1w25ob5 659 31 % % NN cord-006856-b1w25ob5 659 32 vs. vs. IN cord-006856-b1w25ob5 659 33 14 14 CD cord-006856-b1w25ob5 659 34 % % NN cord-006856-b1w25ob5 659 35 , , , cord-006856-b1w25ob5 659 36 P p NN cord-006856-b1w25ob5 659 37 < < XX cord-006856-b1w25ob5 659 38 0.002 0.002 CD cord-006856-b1w25ob5 659 39 ) ) -RRB- cord-006856-b1w25ob5 659 40 . . . cord-006856-b1w25ob5 660 1 Anti anti JJ cord-006856-b1w25ob5 660 2 - - JJ cord-006856-b1w25ob5 660 3 HBcAB hbcab JJ cord-006856-b1w25ob5 660 4 - - HYPH cord-006856-b1w25ob5 660 5 positive positive JJ cord-006856-b1w25ob5 660 6 donors donor NNS cord-006856-b1w25ob5 660 7 were be VBD cord-006856-b1w25ob5 660 8 more more RBR cord-006856-b1w25ob5 660 9 frequently frequently RB cord-006856-b1w25ob5 660 10 non non JJ cord-006856-b1w25ob5 660 11 - - JJ cord-006856-b1w25ob5 660 12 Caucasian caucasian JJ cord-006856-b1w25ob5 660 13 ( ( -LRB- cord-006856-b1w25ob5 660 14 60 60 CD cord-006856-b1w25ob5 660 15 vs. vs. JJ cord-006856-b1w25ob5 660 16 24 24 CD cord-006856-b1w25ob5 660 17 % % NN cord-006856-b1w25ob5 660 18 , , , cord-006856-b1w25ob5 660 19 P p NN cord-006856-b1w25ob5 660 20 < < XX cord-006856-b1w25ob5 660 21 0.001 0.001 CD cord-006856-b1w25ob5 660 22 ) ) -RRB- cord-006856-b1w25ob5 660 23 and and CC cord-006856-b1w25ob5 660 24 CMV CMV NNP cord-006856-b1w25ob5 660 25 seropositive seropositive JJ cord-006856-b1w25ob5 660 26 ( ( -LRB- cord-006856-b1w25ob5 660 27 85 85 CD cord-006856-b1w25ob5 660 28 % % NN cord-006856-b1w25ob5 660 29 vs. vs. CC cord-006856-b1w25ob5 660 30 65 65 CD cord-006856-b1w25ob5 660 31 % % NN cord-006856-b1w25ob5 660 32 , , , cord-006856-b1w25ob5 660 33 P p NN cord-006856-b1w25ob5 660 34 < < XX cord-006856-b1w25ob5 660 35 0.035 0.035 CD cord-006856-b1w25ob5 660 36 ) ) -RRB- cord-006856-b1w25ob5 660 37 . . . cord-006856-b1w25ob5 661 1 Survival survival NN cord-006856-b1w25ob5 661 2 of of IN cord-006856-b1w25ob5 661 3 anti anti JJ cord-006856-b1w25ob5 661 4 - - JJ cord-006856-b1w25ob5 661 5 HBcAB hbcab JJ cord-006856-b1w25ob5 661 6 - - HYPH cord-006856-b1w25ob5 661 7 positive positive JJ cord-006856-b1w25ob5 661 8 individuals individual NNS cord-006856-b1w25ob5 661 9 and and CC cord-006856-b1w25ob5 661 10 recipients recipient NNS cord-006856-b1w25ob5 661 11 of of IN cord-006856-b1w25ob5 661 12 allografts allograft NNS cord-006856-b1w25ob5 661 13 from from IN cord-006856-b1w25ob5 661 14 anti anti JJ cord-006856-b1w25ob5 661 15 - - JJ cord-006856-b1w25ob5 661 16 HBcAB hbcab JJ cord-006856-b1w25ob5 661 17 - - HYPH cord-006856-b1w25ob5 661 18 positive positive JJ cord-006856-b1w25ob5 661 19 donors donor NNS cord-006856-b1w25ob5 661 20 did do VBD cord-006856-b1w25ob5 661 21 not not RB cord-006856-b1w25ob5 661 22 differ differ VB cord-006856-b1w25ob5 661 23 from from IN cord-006856-b1w25ob5 661 24 their -PRON- PRP$ cord-006856-b1w25ob5 661 25 anti anti JJ cord-006856-b1w25ob5 661 26 - - JJ cord-006856-b1w25ob5 661 27 HBcAB hbcab JJ cord-006856-b1w25ob5 661 28 - - HYPH cord-006856-b1w25ob5 661 29 negative negative JJ cord-006856-b1w25ob5 661 30 counterparts counterpart NNS cord-006856-b1w25ob5 661 31 . . . cord-006856-b1w25ob5 662 1 There there EX cord-006856-b1w25ob5 662 2 were be VBD cord-006856-b1w25ob5 662 3 no no DT cord-006856-b1w25ob5 662 4 reported report VBN cord-006856-b1w25ob5 662 5 cases case NNS cord-006856-b1w25ob5 662 6 of of IN cord-006856-b1w25ob5 662 7 recurrent recurrent JJ cord-006856-b1w25ob5 662 8 hepatitis hepatitis NN cord-006856-b1w25ob5 662 9 B B NNP cord-006856-b1w25ob5 662 10 in in IN cord-006856-b1w25ob5 662 11 anti anti JJ cord-006856-b1w25ob5 662 12 - - JJ cord-006856-b1w25ob5 662 13 HBcAB hbcab JJ cord-006856-b1w25ob5 662 14 recipients recipient NNS cord-006856-b1w25ob5 662 15 or or CC cord-006856-b1w25ob5 662 16 patients patient NNS cord-006856-b1w25ob5 662 17 receiving receive VBG cord-006856-b1w25ob5 662 18 LT LT NNP cord-006856-b1w25ob5 662 19 for for IN cord-006856-b1w25ob5 662 20 HBV HBV NNP cord-006856-b1w25ob5 662 21 - - HYPH cord-006856-b1w25ob5 662 22 associated associate VBN cord-006856-b1w25ob5 662 23 liver liver NN cord-006856-b1w25ob5 662 24 disease disease NN cord-006856-b1w25ob5 662 25 . . . cord-006856-b1w25ob5 663 1 Three three CD cord-006856-b1w25ob5 663 2 cases case NNS cord-006856-b1w25ob5 663 3 of of IN cord-006856-b1w25ob5 663 4 de de NNP cord-006856-b1w25ob5 663 5 novo novo NNP cord-006856-b1w25ob5 663 6 acute acute JJ cord-006856-b1w25ob5 663 7 posttransplant posttransplant NNP cord-006856-b1w25ob5 663 8 hepatitis hepatitis NN cord-006856-b1w25ob5 663 9 B B NNP cord-006856-b1w25ob5 663 10 were be VBD cord-006856-b1w25ob5 663 11 identified identify VBN cord-006856-b1w25ob5 663 12 , , , cord-006856-b1w25ob5 663 13 one one CD cord-006856-b1w25ob5 663 14 being be VBG cord-006856-b1w25ob5 663 15 acquired acquire VBN cord-006856-b1w25ob5 663 16 during during IN cord-006856-b1w25ob5 663 17 unprotected unprotected JJ cord-006856-b1w25ob5 663 18 intercourse intercourse NN cord-006856-b1w25ob5 663 19 and and CC cord-006856-b1w25ob5 663 20 two two CD cord-006856-b1w25ob5 663 21 being be VBG cord-006856-b1w25ob5 663 22 transmitted transmit VBN cord-006856-b1w25ob5 663 23 through through IN cord-006856-b1w25ob5 663 24 the the DT cord-006856-b1w25ob5 663 25 graft graft NN cord-006856-b1w25ob5 663 26 . . . cord-006856-b1w25ob5 664 1 The the DT cord-006856-b1w25ob5 664 2 two two CD cord-006856-b1w25ob5 664 3 with with IN cord-006856-b1w25ob5 664 4 graft graft NN cord-006856-b1w25ob5 664 5 - - HYPH cord-006856-b1w25ob5 664 6 transmitted transmit VBN cord-006856-b1w25ob5 664 7 disease disease NN cord-006856-b1w25ob5 664 8 were be VBD cord-006856-b1w25ob5 664 9 anti anti JJ cord-006856-b1w25ob5 664 10 - - JJ cord-006856-b1w25ob5 664 11 HBcAb hbcab JJ cord-006856-b1w25ob5 664 12 negative negative JJ cord-006856-b1w25ob5 664 13 , , , cord-006856-b1w25ob5 664 14 treated treat VBN cord-006856-b1w25ob5 664 15 initially initially RB cord-006856-b1w25ob5 664 16 with with IN cord-006856-b1w25ob5 664 17 lamivudine lamivudine NN cord-006856-b1w25ob5 664 18 and and CC cord-006856-b1w25ob5 664 19 were be VBD cord-006856-b1w25ob5 664 20 switched switch VBN cord-006856-b1w25ob5 664 21 to to IN cord-006856-b1w25ob5 664 22 adefovir adefovir NNP cord-006856-b1w25ob5 664 23 due due IN cord-006856-b1w25ob5 664 24 to to IN cord-006856-b1w25ob5 664 25 the the DT cord-006856-b1w25ob5 664 26 emergence emergence NN cord-006856-b1w25ob5 664 27 of of IN cord-006856-b1w25ob5 664 28 YMDD YMDD NNP cord-006856-b1w25ob5 664 29 mutants mutant NNS cord-006856-b1w25ob5 664 30 . . . cord-006856-b1w25ob5 665 1 Conclusions conclusion NNS cord-006856-b1w25ob5 665 2 . . . cord-006856-b1w25ob5 666 1 The the DT cord-006856-b1w25ob5 666 2 frequency frequency NN cord-006856-b1w25ob5 666 3 of of IN cord-006856-b1w25ob5 666 4 anti anti JJ cord-006856-b1w25ob5 666 5 - - JJ cord-006856-b1w25ob5 666 6 HbcAB hbcab JJ cord-006856-b1w25ob5 666 7 - - HYPH cord-006856-b1w25ob5 666 8 positive positive JJ cord-006856-b1w25ob5 666 9 recipients recipient NNS cord-006856-b1w25ob5 666 10 in in IN cord-006856-b1w25ob5 666 11 our -PRON- PRP$ cord-006856-b1w25ob5 666 12 series series NN cord-006856-b1w25ob5 666 13 was be VBD cord-006856-b1w25ob5 666 14 higher high JJR cord-006856-b1w25ob5 666 15 than than IN cord-006856-b1w25ob5 666 16 expected expect VBN cord-006856-b1w25ob5 666 17 . . . cord-006856-b1w25ob5 667 1 These these DT cord-006856-b1w25ob5 667 2 individuals individual NNS cord-006856-b1w25ob5 667 3 seem seem VBP cord-006856-b1w25ob5 667 4 at at IN cord-006856-b1w25ob5 667 5 minimal minimal JJ cord-006856-b1w25ob5 667 6 risk risk NN cord-006856-b1w25ob5 667 7 for for IN cord-006856-b1w25ob5 667 8 posttransplant posttransplant NNP cord-006856-b1w25ob5 667 9 hepatitis hepatitis NNP cord-006856-b1w25ob5 667 10 B. B. NNP cord-006856-b1w25ob5 667 11 Recurrence recurrence NN cord-006856-b1w25ob5 667 12 of of IN cord-006856-b1w25ob5 667 13 HBV HBV NNP cord-006856-b1w25ob5 667 14 after after IN cord-006856-b1w25ob5 667 15 LT LT NNP cord-006856-b1w25ob5 667 16 in in IN cord-006856-b1w25ob5 667 17 the the DT cord-006856-b1w25ob5 667 18 setting setting NN cord-006856-b1w25ob5 667 19 of of IN cord-006856-b1w25ob5 667 20 HBIg HBIg NNS cord-006856-b1w25ob5 667 21 / / SYM cord-006856-b1w25ob5 667 22 lamivudine lamivudine JJ cord-006856-b1w25ob5 667 23 prophylaxis prophylaxis NN cord-006856-b1w25ob5 667 24 is be VBZ cord-006856-b1w25ob5 667 25 extremely extremely RB cord-006856-b1w25ob5 667 26 rare rare JJ cord-006856-b1w25ob5 667 27 with with IN cord-006856-b1w25ob5 667 28 5-year 5-year CD cord-006856-b1w25ob5 667 29 median median JJ cord-006856-b1w25ob5 667 30 follow follow NN cord-006856-b1w25ob5 667 31 - - HYPH cord-006856-b1w25ob5 667 32 up up NN cord-006856-b1w25ob5 667 33 . . . cord-006856-b1w25ob5 668 1 The the DT cord-006856-b1w25ob5 668 2 risk risk NN cord-006856-b1w25ob5 668 3 of of IN cord-006856-b1w25ob5 668 4 transmission transmission NN cord-006856-b1w25ob5 668 5 of of IN cord-006856-b1w25ob5 668 6 HBV HBV NNP cord-006856-b1w25ob5 668 7 through through IN cord-006856-b1w25ob5 668 8 anti anti JJ cord-006856-b1w25ob5 668 9 - - JJ cord-006856-b1w25ob5 668 10 HbcAB hbcab JJ cord-006856-b1w25ob5 668 11 - - HYPH cord-006856-b1w25ob5 668 12 positive positive JJ cord-006856-b1w25ob5 668 13 livers liver NNS cord-006856-b1w25ob5 668 14 despite despite IN cord-006856-b1w25ob5 668 15 prophylaxis prophylaxis NN cord-006856-b1w25ob5 668 16 can can MD cord-006856-b1w25ob5 668 17 not not RB cord-006856-b1w25ob5 668 18 be be VB cord-006856-b1w25ob5 668 19 neglected neglect VBN cord-006856-b1w25ob5 668 20 and and CC cord-006856-b1w25ob5 668 21 the the DT cord-006856-b1w25ob5 668 22 emergence emergence NN cord-006856-b1w25ob5 668 23 of of IN cord-006856-b1w25ob5 668 24 an an DT cord-006856-b1w25ob5 668 25 YMDD YMDD NNP cord-006856-b1w25ob5 668 26 mutant mutant NN cord-006856-b1w25ob5 668 27 is be VBZ cord-006856-b1w25ob5 668 28 of of IN cord-006856-b1w25ob5 668 29 particular particular JJ cord-006856-b1w25ob5 668 30 concern concern NN cord-006856-b1w25ob5 668 31 . . . cord-006856-b1w25ob5 669 1 Anti anti JJ cord-006856-b1w25ob5 669 2 - - JJ cord-006856-b1w25ob5 669 3 HbcAB hbcab JJ cord-006856-b1w25ob5 669 4 - - HYPH cord-006856-b1w25ob5 669 5 positive positive JJ cord-006856-b1w25ob5 669 6 grafts graft NNS cord-006856-b1w25ob5 669 7 should should MD cord-006856-b1w25ob5 669 8 be be VB cord-006856-b1w25ob5 669 9 preferably preferably RB cord-006856-b1w25ob5 669 10 given give VBN cord-006856-b1w25ob5 669 11 to to IN cord-006856-b1w25ob5 669 12 anti anti JJ cord-006856-b1w25ob5 669 13 - - JJ cord-006856-b1w25ob5 669 14 HbcAB hbcab JJ cord-006856-b1w25ob5 669 15 - - HYPH cord-006856-b1w25ob5 669 16 positive positive JJ cord-006856-b1w25ob5 669 17 recipients recipient NNS cord-006856-b1w25ob5 669 18 . . . cord-006856-b1w25ob5 670 1 V36 V36 NNP cord-006856-b1w25ob5 671 1 The the DT cord-006856-b1w25ob5 671 2 response response NN cord-006856-b1w25ob5 671 3 to to IN cord-006856-b1w25ob5 671 4 preoperative preoperative JJ cord-006856-b1w25ob5 671 5 transarterial transarterial JJ cord-006856-b1w25ob5 671 6 chemoembolisation chemoembolisation NN cord-006856-b1w25ob5 671 7 predicts predict VBZ cord-006856-b1w25ob5 671 8 outcome outcome NN cord-006856-b1w25ob5 671 9 of of IN cord-006856-b1w25ob5 671 10 patients patient NNS cord-006856-b1w25ob5 671 11 with with IN cord-006856-b1w25ob5 671 12 hepatocellular hepatocellular JJ cord-006856-b1w25ob5 671 13 carcinoma carcinoma NN cord-006856-b1w25ob5 671 14 after after IN cord-006856-b1w25ob5 671 15 liver liver NN cord-006856-b1w25ob5 671 16 transplantation transplantation NN cord-006856-b1w25ob5 671 17 Division Division NNP cord-006856-b1w25ob5 671 18 of of IN cord-006856-b1w25ob5 671 19 Gastroenterology Gastroenterology NNP cord-006856-b1w25ob5 671 20 and and CC cord-006856-b1w25ob5 671 21 Hepatology Hepatology NNP cord-006856-b1w25ob5 671 22 , , , cord-006856-b1w25ob5 671 23 Department Department NNP cord-006856-b1w25ob5 671 24 of of IN cord-006856-b1w25ob5 671 25 Internal Internal NNP cord-006856-b1w25ob5 671 26 Medicine Medicine NNP cord-006856-b1w25ob5 671 27 , , , cord-006856-b1w25ob5 671 28 Medical Medical NNP cord-006856-b1w25ob5 671 29 Unversity Unversity NNP cord-006856-b1w25ob5 671 30 of of IN cord-006856-b1w25ob5 671 31 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 671 32 , , , cord-006856-b1w25ob5 671 33 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 671 34 , , , cord-006856-b1w25ob5 671 35 Austria Austria NNP cord-006856-b1w25ob5 671 36 Liver Liver NNP cord-006856-b1w25ob5 671 37 transplantation transplantation NN cord-006856-b1w25ob5 671 38 ( ( -LRB- cord-006856-b1w25ob5 671 39 LT LT NNP cord-006856-b1w25ob5 671 40 ) ) -RRB- cord-006856-b1w25ob5 671 41 is be VBZ cord-006856-b1w25ob5 671 42 the the DT cord-006856-b1w25ob5 671 43 only only JJ cord-006856-b1w25ob5 671 44 curative curative JJ cord-006856-b1w25ob5 671 45 therapy therapy NN cord-006856-b1w25ob5 671 46 for for IN cord-006856-b1w25ob5 671 47 patients patient NNS cord-006856-b1w25ob5 671 48 with with IN cord-006856-b1w25ob5 671 49 early early JJ cord-006856-b1w25ob5 671 50 - - HYPH cord-006856-b1w25ob5 671 51 stage stage NN cord-006856-b1w25ob5 671 52 hepatocellular hepatocellular JJ cord-006856-b1w25ob5 671 53 carcinoma carcinoma NN cord-006856-b1w25ob5 671 54 ( ( -LRB- cord-006856-b1w25ob5 671 55 HCC HCC NNP cord-006856-b1w25ob5 671 56 ) ) -RRB- cord-006856-b1w25ob5 671 57 . . . cord-006856-b1w25ob5 672 1 The the DT cord-006856-b1w25ob5 672 2 impact impact NN cord-006856-b1w25ob5 672 3 of of IN cord-006856-b1w25ob5 672 4 preLT preLT NNP cord-006856-b1w25ob5 672 5 chemoembolisation chemoembolisation NN cord-006856-b1w25ob5 672 6 ( ( -LRB- cord-006856-b1w25ob5 672 7 CE CE NNP cord-006856-b1w25ob5 672 8 ) ) -RRB- cord-006856-b1w25ob5 672 9 on on IN cord-006856-b1w25ob5 672 10 patient patient JJ cord-006856-b1w25ob5 672 11 survival survival NN cord-006856-b1w25ob5 672 12 and and CC cord-006856-b1w25ob5 672 13 incidence incidence NN cord-006856-b1w25ob5 672 14 of of IN cord-006856-b1w25ob5 672 15 HCC HCC NNP cord-006856-b1w25ob5 672 16 recurrence recurrence NN cord-006856-b1w25ob5 672 17 has have VBZ cord-006856-b1w25ob5 672 18 been be VBN cord-006856-b1w25ob5 672 19 controversially controversially RB cord-006856-b1w25ob5 672 20 discussed discuss VBN cord-006856-b1w25ob5 672 21 and and CC cord-006856-b1w25ob5 672 22 remains remain VBZ cord-006856-b1w25ob5 672 23 undetermined undetermined JJ cord-006856-b1w25ob5 672 24 . . . cord-006856-b1w25ob5 673 1 The the DT cord-006856-b1w25ob5 673 2 aim aim NN cord-006856-b1w25ob5 673 3 of of IN cord-006856-b1w25ob5 673 4 this this DT cord-006856-b1w25ob5 673 5 study study NN cord-006856-b1w25ob5 673 6 was be VBD cord-006856-b1w25ob5 673 7 to to TO cord-006856-b1w25ob5 673 8 evaluate evaluate VB cord-006856-b1w25ob5 673 9 the the DT cord-006856-b1w25ob5 673 10 efficacy efficacy NN cord-006856-b1w25ob5 673 11 of of IN cord-006856-b1w25ob5 673 12 CE CE NNP cord-006856-b1w25ob5 673 13 prior prior RB cord-006856-b1w25ob5 673 14 to to IN cord-006856-b1w25ob5 673 15 LT LT NNP cord-006856-b1w25ob5 673 16 in in IN cord-006856-b1w25ob5 673 17 HCC HCC NNP cord-006856-b1w25ob5 673 18 patients patient NNS cord-006856-b1w25ob5 673 19 with with IN cord-006856-b1w25ob5 673 20 regard regard NN cord-006856-b1w25ob5 673 21 to to IN cord-006856-b1w25ob5 673 22 tumor tumor NN cord-006856-b1w25ob5 673 23 recurrence recurrence NN cord-006856-b1w25ob5 673 24 and and CC cord-006856-b1w25ob5 673 25 patient patient JJ cord-006856-b1w25ob5 673 26 outcome outcome NN cord-006856-b1w25ob5 673 27 . . . cord-006856-b1w25ob5 674 1 Between between IN cord-006856-b1w25ob5 674 2 1984 1984 CD cord-006856-b1w25ob5 674 3 and and CC cord-006856-b1w25ob5 674 4 2004 2004 CD cord-006856-b1w25ob5 674 5 , , , cord-006856-b1w25ob5 674 6 167 167 CD cord-006856-b1w25ob5 674 7 HCC HCC NNP cord-006856-b1w25ob5 674 8 patients patient NNS cord-006856-b1w25ob5 674 9 ( ( -LRB- cord-006856-b1w25ob5 674 10 142 142 CD cord-006856-b1w25ob5 674 11 m m NN cord-006856-b1w25ob5 674 12 ; ; : cord-006856-b1w25ob5 674 13 25 25 CD cord-006856-b1w25ob5 674 14 f f NNS cord-006856-b1w25ob5 674 15 ) ) -RRB- cord-006856-b1w25ob5 674 16 underwent undergo VBD cord-006856-b1w25ob5 674 17 LT LT NNP cord-006856-b1w25ob5 674 18 at at IN cord-006856-b1w25ob5 674 19 our -PRON- PRP$ cord-006856-b1w25ob5 674 20 institution institution NN cord-006856-b1w25ob5 674 21 . . . cord-006856-b1w25ob5 675 1 The the DT cord-006856-b1w25ob5 675 2 underlying underlying JJ cord-006856-b1w25ob5 675 3 liver liver NN cord-006856-b1w25ob5 675 4 disease disease NN cord-006856-b1w25ob5 675 5 was be VBD cord-006856-b1w25ob5 675 6 viral viral JJ cord-006856-b1w25ob5 675 7 hepatitis hepatitis NN cord-006856-b1w25ob5 675 8 in in IN cord-006856-b1w25ob5 675 9 87 87 CD cord-006856-b1w25ob5 676 1 ( ( -LRB- cord-006856-b1w25ob5 676 2 HCV HCV NNP cord-006856-b1w25ob5 676 3 69 69 CD cord-006856-b1w25ob5 676 4 , , , cord-006856-b1w25ob5 676 5 HBV HBV NNP cord-006856-b1w25ob5 676 6 18 18 CD cord-006856-b1w25ob5 676 7 ) ) -RRB- cord-006856-b1w25ob5 676 8 , , , cord-006856-b1w25ob5 676 9 alcoholic alcoholic JJ cord-006856-b1w25ob5 676 10 liver liver NN cord-006856-b1w25ob5 676 11 cirrhosis cirrhosis NN cord-006856-b1w25ob5 676 12 in in IN cord-006856-b1w25ob5 676 13 49 49 CD cord-006856-b1w25ob5 676 14 , , , cord-006856-b1w25ob5 676 15 and and CC cord-006856-b1w25ob5 676 16 other other JJ cord-006856-b1w25ob5 676 17 diseases disease NNS cord-006856-b1w25ob5 676 18 in in IN cord-006856-b1w25ob5 676 19 18 18 CD cord-006856-b1w25ob5 676 20 patients patient NNS cord-006856-b1w25ob5 676 21 . . . cord-006856-b1w25ob5 677 1 According accord VBG cord-006856-b1w25ob5 677 2 to to IN cord-006856-b1w25ob5 677 3 Child child NN cord-006856-b1w25ob5 677 4 - - HYPH cord-006856-b1w25ob5 677 5 Pugh Pugh NNP cord-006856-b1w25ob5 677 6 classification classification NN cord-006856-b1w25ob5 677 7 , , , cord-006856-b1w25ob5 677 8 75 75 CD cord-006856-b1w25ob5 677 9 patients patient NNS cord-006856-b1w25ob5 677 10 presented present VBN cord-006856-b1w25ob5 677 11 with with IN cord-006856-b1w25ob5 677 12 Child Child NNP cord-006856-b1w25ob5 677 13 A A NNP cord-006856-b1w25ob5 677 14 , , , cord-006856-b1w25ob5 677 15 79 79 CD cord-006856-b1w25ob5 677 16 with with IN cord-006856-b1w25ob5 677 17 stage stage NN cord-006856-b1w25ob5 677 18 B b NN cord-006856-b1w25ob5 677 19 and and CC cord-006856-b1w25ob5 677 20 9 9 CD cord-006856-b1w25ob5 677 21 with with IN cord-006856-b1w25ob5 677 22 stage stage NN cord-006856-b1w25ob5 677 23 C. C. NNP cord-006856-b1w25ob5 677 24 HCCs hcc NNS cord-006856-b1w25ob5 677 25 were be VBD cord-006856-b1w25ob5 677 26 diagnosed diagnose VBN cord-006856-b1w25ob5 677 27 according accord VBG cord-006856-b1w25ob5 677 28 to to IN cord-006856-b1w25ob5 677 29 the the DT cord-006856-b1w25ob5 677 30 EASL EASL NNP cord-006856-b1w25ob5 677 31 guidelines guideline NNS cord-006856-b1w25ob5 677 32 . . . cord-006856-b1w25ob5 678 1 On on IN cord-006856-b1w25ob5 678 2 the the DT cord-006856-b1w25ob5 678 3 basis basis NN cord-006856-b1w25ob5 678 4 of of IN cord-006856-b1w25ob5 678 5 preLT preLT NNP cord-006856-b1w25ob5 678 6 radiology radiology NN cord-006856-b1w25ob5 678 7 , , , cord-006856-b1w25ob5 678 8 23 23 CD cord-006856-b1w25ob5 678 9 patients patient NNS cord-006856-b1w25ob5 678 10 were be VBD cord-006856-b1w25ob5 678 11 diagnosed diagnose VBN cord-006856-b1w25ob5 678 12 with with IN cord-006856-b1w25ob5 678 13 stage stage NN cord-006856-b1w25ob5 679 1 I -PRON- PRP cord-006856-b1w25ob5 679 2 , , , cord-006856-b1w25ob5 679 3 79 79 CD cord-006856-b1w25ob5 679 4 stage stage NN cord-006856-b1w25ob5 679 5 II II NNP cord-006856-b1w25ob5 679 6 , , , cord-006856-b1w25ob5 679 7 34 34 CD cord-006856-b1w25ob5 679 8 stage stage NN cord-006856-b1w25ob5 679 9 III III NNP cord-006856-b1w25ob5 679 10 , , , cord-006856-b1w25ob5 679 11 and and CC cord-006856-b1w25ob5 679 12 31 31 CD cord-006856-b1w25ob5 679 13 stage stage NN cord-006856-b1w25ob5 679 14 IV IV NNP cord-006856-b1w25ob5 680 1 according accord VBG cord-006856-b1w25ob5 680 2 to to IN cord-006856-b1w25ob5 680 3 the the DT cord-006856-b1w25ob5 680 4 modified modify VBN cord-006856-b1w25ob5 680 5 UICC UICC NNP cord-006856-b1w25ob5 680 6 criteria criterion NNS cord-006856-b1w25ob5 680 7 . . . cord-006856-b1w25ob5 681 1 CE CE NNP cord-006856-b1w25ob5 681 2 was be VBD cord-006856-b1w25ob5 681 3 performed perform VBN cord-006856-b1w25ob5 681 4 in in IN cord-006856-b1w25ob5 681 5 120 120 CD cord-006856-b1w25ob5 681 6 patients patient NNS cord-006856-b1w25ob5 681 7 prior prior RB cord-006856-b1w25ob5 681 8 to to IN cord-006856-b1w25ob5 681 9 LT LT NNP cord-006856-b1w25ob5 681 10 . . . cord-006856-b1w25ob5 682 1 In in IN cord-006856-b1w25ob5 682 2 47 47 CD cord-006856-b1w25ob5 682 3 patients patient NNS cord-006856-b1w25ob5 682 4 no no DT cord-006856-b1w25ob5 682 5 treatment treatment NN cord-006856-b1w25ob5 682 6 was be VBD cord-006856-b1w25ob5 682 7 performed perform VBN cord-006856-b1w25ob5 682 8 prior prior RB cord-006856-b1w25ob5 682 9 to to IN cord-006856-b1w25ob5 682 10 LT LT NNP cord-006856-b1w25ob5 682 11 . . . cord-006856-b1w25ob5 683 1 Patients patient NNS cord-006856-b1w25ob5 683 2 underwent undergo VBD cord-006856-b1w25ob5 683 3 multiple multiple JJ cord-006856-b1w25ob5 683 4 cycles cycle NNS cord-006856-b1w25ob5 683 5 of of IN cord-006856-b1w25ob5 683 6 CE CE NNP cord-006856-b1w25ob5 683 7 ( ( -LRB- cord-006856-b1w25ob5 683 8 mean mean UH cord-006856-b1w25ob5 683 9 , , , cord-006856-b1w25ob5 683 10 1.6 1.6 CD cord-006856-b1w25ob5 683 11 CE ce NN cord-006856-b1w25ob5 683 12 / / SYM cord-006856-b1w25ob5 683 13 patient patient NN cord-006856-b1w25ob5 683 14 ) ) -RRB- cord-006856-b1w25ob5 683 15 . . . cord-006856-b1w25ob5 684 1 CE CE NNP cord-006856-b1w25ob5 684 2 response response NN cord-006856-b1w25ob5 684 3 prior prior RB cord-006856-b1w25ob5 684 4 to to IN cord-006856-b1w25ob5 684 5 CE CE NNP cord-006856-b1w25ob5 684 6 was be VBD cord-006856-b1w25ob5 684 7 assessed assess VBN cord-006856-b1w25ob5 684 8 by by IN cord-006856-b1w25ob5 684 9 CT CT NNP cord-006856-b1w25ob5 684 10 scan scan NN cord-006856-b1w25ob5 684 11 . . . cord-006856-b1w25ob5 685 1 On on IN cord-006856-b1w25ob5 685 2 explant explant NN cord-006856-b1w25ob5 685 3 histology histology NN cord-006856-b1w25ob5 685 4 , , , cord-006856-b1w25ob5 685 5 complete complete JJ cord-006856-b1w25ob5 685 6 response response NN cord-006856-b1w25ob5 685 7 with with IN cord-006856-b1w25ob5 685 8 no no DT cord-006856-b1w25ob5 685 9 evidence evidence NN cord-006856-b1w25ob5 685 10 of of IN cord-006856-b1w25ob5 685 11 vital vital JJ cord-006856-b1w25ob5 685 12 tumor tumor NN cord-006856-b1w25ob5 685 13 was be VBD cord-006856-b1w25ob5 685 14 found find VBN cord-006856-b1w25ob5 685 15 in in IN cord-006856-b1w25ob5 685 16 38 38 CD cord-006856-b1w25ob5 685 17 of of IN cord-006856-b1w25ob5 685 18 120 120 CD cord-006856-b1w25ob5 685 19 ( ( -LRB- cord-006856-b1w25ob5 685 20 32 32 CD cord-006856-b1w25ob5 685 21 % % NN cord-006856-b1w25ob5 685 22 ) ) -RRB- cord-006856-b1w25ob5 685 23 patients patient NNS cord-006856-b1w25ob5 685 24 , , , cord-006856-b1w25ob5 685 25 55 55 CD cord-006856-b1w25ob5 685 26 ( ( -LRB- cord-006856-b1w25ob5 685 27 46 46 CD cord-006856-b1w25ob5 685 28 % % NN cord-006856-b1w25ob5 685 29 ) ) -RRB- cord-006856-b1w25ob5 685 30 patients patient NNS cord-006856-b1w25ob5 685 31 showed show VBD cord-006856-b1w25ob5 685 32 a a DT cord-006856-b1w25ob5 685 33 partial partial JJ cord-006856-b1w25ob5 685 34 remission remission NN cord-006856-b1w25ob5 685 35 ( ( -LRB- cord-006856-b1w25ob5 685 36 tumor tumor NN cord-006856-b1w25ob5 685 37 necrosis necrosis NN cord-006856-b1w25ob5 685 38 , , , cord-006856-b1w25ob5 685 39 > > XX cord-006856-b1w25ob5 685 40 50 50 CD cord-006856-b1w25ob5 685 41 % % NN cord-006856-b1w25ob5 685 42 ) ) -RRB- cord-006856-b1w25ob5 685 43 , , , cord-006856-b1w25ob5 685 44 and and CC cord-006856-b1w25ob5 685 45 27 27 CD cord-006856-b1w25ob5 685 46 ( ( -LRB- cord-006856-b1w25ob5 685 47 22 22 CD cord-006856-b1w25ob5 685 48 % % NN cord-006856-b1w25ob5 685 49 ) ) -RRB- cord-006856-b1w25ob5 685 50 patients patient NNS cord-006856-b1w25ob5 685 51 showed show VBD cord-006856-b1w25ob5 685 52 a a DT cord-006856-b1w25ob5 685 53 poor poor JJ cord-006856-b1w25ob5 685 54 response response NN cord-006856-b1w25ob5 685 55 or or CC cord-006856-b1w25ob5 685 56 even even RB cord-006856-b1w25ob5 685 57 progression progression NN cord-006856-b1w25ob5 685 58 . . . cord-006856-b1w25ob5 686 1 The the DT cord-006856-b1w25ob5 686 2 intention intention NN cord-006856-b1w25ob5 686 3 - - HYPH cord-006856-b1w25ob5 686 4 totreat totreat NN cord-006856-b1w25ob5 686 5 analysis analysis NN cord-006856-b1w25ob5 686 6 showed show VBD cord-006856-b1w25ob5 686 7 that that IN cord-006856-b1w25ob5 686 8 patients patient NNS cord-006856-b1w25ob5 686 9 with with IN cord-006856-b1w25ob5 686 10 early early JJ cord-006856-b1w25ob5 686 11 - - HYPH cord-006856-b1w25ob5 686 12 stage stage NN cord-006856-b1w25ob5 686 13 HCC HCC NNP cord-006856-b1w25ob5 686 14 showed show VBD cord-006856-b1w25ob5 686 15 an an DT cord-006856-b1w25ob5 686 16 excellent excellent JJ cord-006856-b1w25ob5 686 17 survival survival NN cord-006856-b1w25ob5 686 18 with with IN cord-006856-b1w25ob5 686 19 a a DT cord-006856-b1w25ob5 686 20 1- 1- NN cord-006856-b1w25ob5 686 21 , , , cord-006856-b1w25ob5 686 22 5- 5- NNP cord-006856-b1w25ob5 686 23 , , , cord-006856-b1w25ob5 686 24 and and CC cord-006856-b1w25ob5 686 25 10-year 10-year CD cord-006856-b1w25ob5 686 26 rate rate NN cord-006856-b1w25ob5 686 27 of of IN cord-006856-b1w25ob5 686 28 98 98 CD cord-006856-b1w25ob5 686 29 % % NN cord-006856-b1w25ob5 686 30 , , , cord-006856-b1w25ob5 686 31 69 69 CD cord-006856-b1w25ob5 686 32 % % NN cord-006856-b1w25ob5 686 33 and and CC cord-006856-b1w25ob5 686 34 69 69 CD cord-006856-b1w25ob5 686 35 % % NN cord-006856-b1w25ob5 686 36 , , , cord-006856-b1w25ob5 686 37 respectively respectively RB cord-006856-b1w25ob5 686 38 . . . cord-006856-b1w25ob5 687 1 CE CE NNP cord-006856-b1w25ob5 687 2 prior prior RB cord-006856-b1w25ob5 687 3 to to IN cord-006856-b1w25ob5 687 4 LT LT NNP cord-006856-b1w25ob5 687 5 had have VBD cord-006856-b1w25ob5 687 6 no no DT cord-006856-b1w25ob5 687 7 positive positive JJ cord-006856-b1w25ob5 687 8 effect effect NN cord-006856-b1w25ob5 687 9 on on IN cord-006856-b1w25ob5 687 10 overall overall JJ cord-006856-b1w25ob5 687 11 patient patient JJ cord-006856-b1w25ob5 687 12 outcome outcome NN cord-006856-b1w25ob5 687 13 and and CC cord-006856-b1w25ob5 687 14 rate rate NN cord-006856-b1w25ob5 687 15 of of IN cord-006856-b1w25ob5 687 16 recurrence recurrence NN cord-006856-b1w25ob5 687 17 . . . cord-006856-b1w25ob5 688 1 However however RB cord-006856-b1w25ob5 688 2 , , , cord-006856-b1w25ob5 688 3 patients patient NNS cord-006856-b1w25ob5 688 4 with with IN cord-006856-b1w25ob5 688 5 complete complete JJ cord-006856-b1w25ob5 688 6 response response NN cord-006856-b1w25ob5 688 7 to to IN cord-006856-b1w25ob5 688 8 CE CE NNP cord-006856-b1w25ob5 688 9 , , , cord-006856-b1w25ob5 688 10 on on IN cord-006856-b1w25ob5 688 11 the the DT cord-006856-b1w25ob5 688 12 basis basis NN cord-006856-b1w25ob5 688 13 of of IN cord-006856-b1w25ob5 688 14 both both DT cord-006856-b1w25ob5 688 15 pre pre JJ cord-006856-b1w25ob5 688 16 LT LT NNP cord-006856-b1w25ob5 688 17 and and CC cord-006856-b1w25ob5 688 18 post post VB cord-006856-b1w25ob5 688 19 LT LT NNP cord-006856-b1w25ob5 688 20 histology histology NN cord-006856-b1w25ob5 688 21 , , , cord-006856-b1w25ob5 688 22 had have VBD cord-006856-b1w25ob5 688 23 a a DT cord-006856-b1w25ob5 688 24 significantly significantly RB cord-006856-b1w25ob5 688 25 bet bet NN cord-006856-b1w25ob5 688 26 - - HYPH cord-006856-b1w25ob5 688 27 ter ter NN cord-006856-b1w25ob5 688 28 long long JJ cord-006856-b1w25ob5 688 29 - - HYPH cord-006856-b1w25ob5 688 30 term term NN cord-006856-b1w25ob5 688 31 survival survival NN cord-006856-b1w25ob5 688 32 ( ( -LRB- cord-006856-b1w25ob5 688 33 1- 1- NNP cord-006856-b1w25ob5 688 34 , , , cord-006856-b1w25ob5 688 35 5- 5- NNP cord-006856-b1w25ob5 688 36 , , , cord-006856-b1w25ob5 688 37 and and CC cord-006856-b1w25ob5 688 38 10-year 10-year CD cord-006856-b1w25ob5 688 39 rates rate NNS cord-006856-b1w25ob5 688 40 of of IN cord-006856-b1w25ob5 688 41 98 98 CD cord-006856-b1w25ob5 688 42 % % NN cord-006856-b1w25ob5 688 43 , , , cord-006856-b1w25ob5 688 44 91 91 CD cord-006856-b1w25ob5 688 45 % % NN cord-006856-b1w25ob5 688 46 , , , cord-006856-b1w25ob5 688 47 and and CC cord-006856-b1w25ob5 688 48 91 91 CD cord-006856-b1w25ob5 688 49 % % NN cord-006856-b1w25ob5 688 50 ) ) -RRB- cord-006856-b1w25ob5 688 51 and and CC cord-006856-b1w25ob5 688 52 rate rate NN cord-006856-b1w25ob5 688 53 of of IN cord-006856-b1w25ob5 688 54 recurrence recurrence NN cord-006856-b1w25ob5 688 55 compared compare VBN cord-006856-b1w25ob5 688 56 to to IN cord-006856-b1w25ob5 688 57 those those DT cord-006856-b1w25ob5 688 58 with with IN cord-006856-b1w25ob5 688 59 partial partial JJ cord-006856-b1w25ob5 688 60 or or CC cord-006856-b1w25ob5 688 61 no no DT cord-006856-b1w25ob5 688 62 response response NN cord-006856-b1w25ob5 688 63 , , , cord-006856-b1w25ob5 688 64 but but CC cord-006856-b1w25ob5 688 65 only only RB cord-006856-b1w25ob5 688 66 in in IN cord-006856-b1w25ob5 688 67 patients patient NNS cord-006856-b1w25ob5 688 68 within within IN cord-006856-b1w25ob5 688 69 Milan Milan NNP cord-006856-b1w25ob5 688 70 and and CC cord-006856-b1w25ob5 688 71 not not RB cord-006856-b1w25ob5 688 72 San San NNP cord-006856-b1w25ob5 688 73 Francisco Francisco NNP cord-006856-b1w25ob5 688 74 criteria criterion NNS cord-006856-b1w25ob5 688 75 . . . cord-006856-b1w25ob5 689 1 The the DT cord-006856-b1w25ob5 689 2 1- 1- NNP cord-006856-b1w25ob5 689 3 , , , cord-006856-b1w25ob5 689 4 5- 5- NNP cord-006856-b1w25ob5 689 5 , , , cord-006856-b1w25ob5 689 6 and and CC cord-006856-b1w25ob5 689 7 10-years 10-years CD cord-006856-b1w25ob5 689 8 survival survival NN cord-006856-b1w25ob5 689 9 rates rate NNS cord-006856-b1w25ob5 689 10 of of IN cord-006856-b1w25ob5 689 11 patients patient NNS cord-006856-b1w25ob5 689 12 with with IN cord-006856-b1w25ob5 689 13 advanced advanced JJ cord-006856-b1w25ob5 689 14 HCC HCC NNP cord-006856-b1w25ob5 689 15 were be VBD cord-006856-b1w25ob5 689 16 95 95 CD cord-006856-b1w25ob5 689 17 % % NN cord-006856-b1w25ob5 689 18 , , , cord-006856-b1w25ob5 689 19 67 67 CD cord-006856-b1w25ob5 689 20 % % NN cord-006856-b1w25ob5 689 21 , , , cord-006856-b1w25ob5 689 22 and and CC cord-006856-b1w25ob5 689 23 35 35 CD cord-006856-b1w25ob5 689 24 % % NN cord-006856-b1w25ob5 689 25 . . . cord-006856-b1w25ob5 690 1 HCC HCC NNP cord-006856-b1w25ob5 690 2 recurrence recurrence NN cord-006856-b1w25ob5 690 3 was be VBD cord-006856-b1w25ob5 690 4 found find VBN cord-006856-b1w25ob5 690 5 in in IN cord-006856-b1w25ob5 690 6 24 24 CD cord-006856-b1w25ob5 690 7 patients patient NNS cord-006856-b1w25ob5 690 8 , , , cord-006856-b1w25ob5 690 9 11 11 CD cord-006856-b1w25ob5 690 10 of of IN cord-006856-b1w25ob5 690 11 24 24 CD cord-006856-b1w25ob5 690 12 presented present VBN cord-006856-b1w25ob5 690 13 with with IN cord-006856-b1w25ob5 690 14 advanced advanced JJ cord-006856-b1w25ob5 690 15 stage stage NN cord-006856-b1w25ob5 690 16 ( ( -LRB- cord-006856-b1w25ob5 690 17 III III NNP cord-006856-b1w25ob5 690 18 and and CC cord-006856-b1w25ob5 690 19 IV IV NNP cord-006856-b1w25ob5 690 20 ) ) -RRB- cord-006856-b1w25ob5 690 21 . . . cord-006856-b1w25ob5 691 1 Only only RB cord-006856-b1w25ob5 691 2 13 13 CD cord-006856-b1w25ob5 691 3 had have VBD cord-006856-b1w25ob5 691 4 undergone undergo VBN cord-006856-b1w25ob5 691 5 CE CE NNP cord-006856-b1w25ob5 691 6 prior prior RB cord-006856-b1w25ob5 691 7 to to IN cord-006856-b1w25ob5 691 8 LT LT NNP cord-006856-b1w25ob5 691 9 , , , cord-006856-b1w25ob5 691 10 and and CC cord-006856-b1w25ob5 691 11 9 9 CD cord-006856-b1w25ob5 691 12 of of IN cord-006856-b1w25ob5 691 13 those those DT cord-006856-b1w25ob5 691 14 were be VBD cord-006856-b1w25ob5 691 15 nonresponders nonresponder NNS cord-006856-b1w25ob5 691 16 to to IN cord-006856-b1w25ob5 691 17 CE CE NNP cord-006856-b1w25ob5 691 18 . . . cord-006856-b1w25ob5 692 1 This this DT cord-006856-b1w25ob5 692 2 study study NN cord-006856-b1w25ob5 692 3 indicates indicate VBZ cord-006856-b1w25ob5 692 4 that that IN cord-006856-b1w25ob5 692 5 response response NN cord-006856-b1w25ob5 692 6 to to IN cord-006856-b1w25ob5 692 7 preLT preLT NNP cord-006856-b1w25ob5 692 8 CE CE NNP cord-006856-b1w25ob5 692 9 may may MD cord-006856-b1w25ob5 692 10 predict predict VB cord-006856-b1w25ob5 692 11 the the DT cord-006856-b1w25ob5 692 12 outcome outcome NN cord-006856-b1w25ob5 692 13 of of IN cord-006856-b1w25ob5 692 14 HCC HCC NNP cord-006856-b1w25ob5 692 15 patients patient NNS cord-006856-b1w25ob5 692 16 after after IN cord-006856-b1w25ob5 692 17 LT LT NNP cord-006856-b1w25ob5 692 18 . . . cord-006856-b1w25ob5 693 1 Patients patient NNS cord-006856-b1w25ob5 693 2 with with IN cord-006856-b1w25ob5 693 3 early early JJ cord-006856-b1w25ob5 693 4 - - HYPH cord-006856-b1w25ob5 693 5 stage stage NN cord-006856-b1w25ob5 693 6 HCC HCC NNP cord-006856-b1w25ob5 693 7 , , , cord-006856-b1w25ob5 693 8 who who WP cord-006856-b1w25ob5 693 9 responded respond VBD cord-006856-b1w25ob5 693 10 to to IN cord-006856-b1w25ob5 693 11 CE CE NNP cord-006856-b1w25ob5 693 12 pre pre JJ cord-006856-b1w25ob5 693 13 LT LT NNP cord-006856-b1w25ob5 693 14 , , , cord-006856-b1w25ob5 693 15 showed show VBD cord-006856-b1w25ob5 693 16 an an DT cord-006856-b1w25ob5 693 17 excellent excellent JJ cord-006856-b1w25ob5 693 18 outcome outcome NN cord-006856-b1w25ob5 693 19 with with IN cord-006856-b1w25ob5 693 20 5-and 5-and CD cord-006856-b1w25ob5 693 21 10-year 10-year CD cord-006856-b1w25ob5 693 22 survival survival NN cord-006856-b1w25ob5 693 23 rates rate NNS cord-006856-b1w25ob5 693 24 around around IN cord-006856-b1w25ob5 693 25 90 90 CD cord-006856-b1w25ob5 693 26 % % NN cord-006856-b1w25ob5 693 27 . . . cord-006856-b1w25ob5 694 1 Patients patient NNS cord-006856-b1w25ob5 694 2 with with IN cord-006856-b1w25ob5 694 3 early early JJ cord-006856-b1w25ob5 694 4 - - HYPH cord-006856-b1w25ob5 694 5 stage stage NN cord-006856-b1w25ob5 694 6 HCC HCC NNP cord-006856-b1w25ob5 694 7 and and CC cord-006856-b1w25ob5 694 8 only only RB cord-006856-b1w25ob5 694 9 partial partial JJ cord-006856-b1w25ob5 694 10 or or CC cord-006856-b1w25ob5 694 11 no no DT cord-006856-b1w25ob5 694 12 response response NN cord-006856-b1w25ob5 694 13 to to IN cord-006856-b1w25ob5 694 14 CE CE NNP cord-006856-b1w25ob5 694 15 had have VBD cord-006856-b1w25ob5 694 16 a a DT cord-006856-b1w25ob5 694 17 higher high JJR cord-006856-b1w25ob5 694 18 risk risk NN cord-006856-b1w25ob5 694 19 of of IN cord-006856-b1w25ob5 694 20 recurrence recurrence NN cord-006856-b1w25ob5 694 21 of of IN cord-006856-b1w25ob5 694 22 HCC HCC NNP cord-006856-b1w25ob5 694 23 after after IN cord-006856-b1w25ob5 694 24 LT LT NNP cord-006856-b1w25ob5 694 25 , , , cord-006856-b1w25ob5 694 26 but but CC cord-006856-b1w25ob5 694 27 outcome outcome NN cord-006856-b1w25ob5 694 28 was be VBD cord-006856-b1w25ob5 694 29 still still RB cord-006856-b1w25ob5 694 30 favorable favorable JJ cord-006856-b1w25ob5 694 31 compared compare VBN cord-006856-b1w25ob5 694 32 with with IN cord-006856-b1w25ob5 694 33 advanced advanced JJ cord-006856-b1w25ob5 694 34 - - HYPH cord-006856-b1w25ob5 694 35 stage stage NN cord-006856-b1w25ob5 694 36 tumors tumor NNS cord-006856-b1w25ob5 694 37 regardless regardless RB cord-006856-b1w25ob5 694 38 of of IN cord-006856-b1w25ob5 694 39 CE CE NNP cord-006856-b1w25ob5 694 40 response response NN cord-006856-b1w25ob5 694 41 . . . cord-006856-b1w25ob5 695 1 The the DT cord-006856-b1w25ob5 695 2 roles role NNS cord-006856-b1w25ob5 695 3 of of IN cord-006856-b1w25ob5 695 4 the the DT cord-006856-b1w25ob5 695 5 regenerative regenerative JJ cord-006856-b1w25ob5 695 6 factors factor NNS cord-006856-b1w25ob5 695 7 hepatocyte hepatocyte VBP cord-006856-b1w25ob5 695 8 growth growth NN cord-006856-b1w25ob5 695 9 factor factor NN cord-006856-b1w25ob5 695 10 ( ( -LRB- cord-006856-b1w25ob5 695 11 HGF HGF NNP cord-006856-b1w25ob5 695 12 ) ) -RRB- cord-006856-b1w25ob5 695 13 , , , cord-006856-b1w25ob5 695 14 transforming transform VBG cord-006856-b1w25ob5 695 15 growth growth NN cord-006856-b1w25ob5 695 16 factor factor NN cord-006856-b1w25ob5 695 17 a a DT cord-006856-b1w25ob5 695 18 ( ( -LRB- cord-006856-b1w25ob5 695 19 TGF TGF NNP cord-006856-b1w25ob5 695 20 - - HYPH cord-006856-b1w25ob5 695 21 a a NN cord-006856-b1w25ob5 695 22 ) ) -RRB- cord-006856-b1w25ob5 695 23 , , , cord-006856-b1w25ob5 695 24 and and CC cord-006856-b1w25ob5 695 25 of of IN cord-006856-b1w25ob5 695 26 vascular vascular JJ cord-006856-b1w25ob5 695 27 endothelial endothelial JJ cord-006856-b1w25ob5 695 28 growth growth NN cord-006856-b1w25ob5 695 29 factor factor NN cord-006856-b1w25ob5 695 30 ( ( -LRB- cord-006856-b1w25ob5 695 31 VEGF VEGF NNP cord-006856-b1w25ob5 695 32 ) ) -RRB- cord-006856-b1w25ob5 695 33 were be VBD cord-006856-b1w25ob5 695 34 described describe VBN cord-006856-b1w25ob5 695 35 in in IN cord-006856-b1w25ob5 695 36 the the DT cord-006856-b1w25ob5 695 37 context context NN cord-006856-b1w25ob5 695 38 of of IN cord-006856-b1w25ob5 695 39 hypertrophy hypertrophy NN cord-006856-b1w25ob5 695 40 and and CC cord-006856-b1w25ob5 695 41 regeneration regeneration NN cord-006856-b1w25ob5 695 42 after after IN cord-006856-b1w25ob5 695 43 liver liver NN cord-006856-b1w25ob5 695 44 resection resection NN cord-006856-b1w25ob5 695 45 but but CC cord-006856-b1w25ob5 695 46 not not RB cord-006856-b1w25ob5 695 47 well well RB cord-006856-b1w25ob5 695 48 known know VBN cord-006856-b1w25ob5 695 49 in in IN cord-006856-b1w25ob5 695 50 the the DT cord-006856-b1w25ob5 695 51 transplantation transplantation NN cord-006856-b1w25ob5 695 52 situation situation NN cord-006856-b1w25ob5 695 53 . . . cord-006856-b1w25ob5 696 1 In in IN cord-006856-b1w25ob5 696 2 the the DT cord-006856-b1w25ob5 696 3 recipients recipient NNS cord-006856-b1w25ob5 696 4 of of IN cord-006856-b1w25ob5 696 5 63 63 CD cord-006856-b1w25ob5 696 6 consecutive consecutive JJ cord-006856-b1w25ob5 696 7 liver liver NN cord-006856-b1w25ob5 696 8 transplantations transplantation NNS cord-006856-b1w25ob5 696 9 with with IN cord-006856-b1w25ob5 696 10 a a DT cord-006856-b1w25ob5 696 11 graft graft NN cord-006856-b1w25ob5 696 12 survival survival NN cord-006856-b1w25ob5 696 13 of of IN cord-006856-b1w25ob5 696 14 > > $ cord-006856-b1w25ob5 696 15 2 2 CD cord-006856-b1w25ob5 696 16 weeks week NNS cord-006856-b1w25ob5 696 17 , , , cord-006856-b1w25ob5 696 18 the the DT cord-006856-b1w25ob5 696 19 factors factor NNS cord-006856-b1w25ob5 696 20 HGF HGF NNP cord-006856-b1w25ob5 696 21 , , , cord-006856-b1w25ob5 696 22 TGF TGF NNP cord-006856-b1w25ob5 696 23 - - , cord-006856-b1w25ob5 696 24 a a NN cord-006856-b1w25ob5 696 25 and and CC cord-006856-b1w25ob5 696 26 VEGF VEGF NNP cord-006856-b1w25ob5 696 27 were be VBD cord-006856-b1w25ob5 696 28 determined determine VBN cord-006856-b1w25ob5 696 29 postoperatively postoperatively RB cord-006856-b1w25ob5 696 30 ( ( -LRB- cord-006856-b1w25ob5 696 31 day day NN cord-006856-b1w25ob5 696 32 1 1 CD cord-006856-b1w25ob5 696 33 , , , cord-006856-b1w25ob5 696 34 3 3 CD cord-006856-b1w25ob5 696 35 , , , cord-006856-b1w25ob5 696 36 5 5 CD cord-006856-b1w25ob5 696 37 , , , cord-006856-b1w25ob5 696 38 7 7 CD cord-006856-b1w25ob5 696 39 , , , cord-006856-b1w25ob5 696 40 10 10 CD cord-006856-b1w25ob5 696 41 , , , cord-006856-b1w25ob5 696 42 14 14 CD cord-006856-b1w25ob5 696 43 ) ) -RRB- cord-006856-b1w25ob5 696 44 by by IN cord-006856-b1w25ob5 696 45 an an DT cord-006856-b1w25ob5 696 46 EL EL NNP cord-006856-b1w25ob5 696 47 - - HYPH cord-006856-b1w25ob5 696 48 ISA ISA NNP cord-006856-b1w25ob5 696 49 in in IN cord-006856-b1w25ob5 696 50 the the DT cord-006856-b1w25ob5 696 51 serum serum NN cord-006856-b1w25ob5 696 52 and and CC cord-006856-b1w25ob5 696 53 correlated correlate VBD cord-006856-b1w25ob5 696 54 to to TO cord-006856-b1w25ob5 696 55 graft graft NN cord-006856-b1w25ob5 696 56 survival survival NN cord-006856-b1w25ob5 696 57 ( ( -LRB- cord-006856-b1w25ob5 696 58 Kaplan Kaplan NNP cord-006856-b1w25ob5 696 59 - - HYPH cord-006856-b1w25ob5 696 60 Meier Meier NNP cord-006856-b1w25ob5 696 61 ) ) -RRB- cord-006856-b1w25ob5 696 62 . . . cord-006856-b1w25ob5 697 1 The the DT cord-006856-b1w25ob5 697 2 median median JJ cord-006856-b1w25ob5 697 3 concentrations concentration NNS cord-006856-b1w25ob5 697 4 of of IN cord-006856-b1w25ob5 697 5 HGF HGF NNP cord-006856-b1w25ob5 697 6 were be VBD cord-006856-b1w25ob5 697 7 constant constant JJ cord-006856-b1w25ob5 697 8 in in IN cord-006856-b1w25ob5 697 9 total total NN cord-006856-b1w25ob5 697 10 during during IN cord-006856-b1w25ob5 697 11 the the DT cord-006856-b1w25ob5 697 12 observation observation NN cord-006856-b1w25ob5 697 13 period period NN cord-006856-b1w25ob5 697 14 ( ( -LRB- cord-006856-b1w25ob5 697 15 day day NN cord-006856-b1w25ob5 697 16 1 1 CD cord-006856-b1w25ob5 697 17 , , , cord-006856-b1w25ob5 697 18 2591 2591 CD cord-006856-b1w25ob5 697 19 pg pg NNP cord-006856-b1w25ob5 697 20 / / SYM cord-006856-b1w25ob5 697 21 ml ml NN cord-006856-b1w25ob5 697 22 ; ; : cord-006856-b1w25ob5 697 23 day day NN cord-006856-b1w25ob5 697 24 7 7 CD cord-006856-b1w25ob5 697 25 , , , cord-006856-b1w25ob5 697 26 2434 2434 CD cord-006856-b1w25ob5 697 27 pg pg NNP cord-006856-b1w25ob5 697 28 / / SYM cord-006856-b1w25ob5 697 29 ml ml NN cord-006856-b1w25ob5 697 30 ; ; : cord-006856-b1w25ob5 697 31 day day NN cord-006856-b1w25ob5 697 32 14 14 CD cord-006856-b1w25ob5 697 33 , , , cord-006856-b1w25ob5 697 34 2490 2490 CD cord-006856-b1w25ob5 697 35 pg pg NNP cord-006856-b1w25ob5 697 36 / / SYM cord-006856-b1w25ob5 697 37 ml ml NNP cord-006856-b1w25ob5 697 38 ) ) -RRB- cord-006856-b1w25ob5 697 39 . . . cord-006856-b1w25ob5 698 1 An an DT cord-006856-b1w25ob5 698 2 individual individual JJ cord-006856-b1w25ob5 698 3 increase increase NN cord-006856-b1w25ob5 698 4 to to IN cord-006856-b1w25ob5 698 5 levels level NNS cord-006856-b1w25ob5 698 6 above above IN cord-006856-b1w25ob5 698 7 4000 4000 CD cord-006856-b1w25ob5 698 8 pg pg NN cord-006856-b1w25ob5 698 9 / / SYM cord-006856-b1w25ob5 698 10 ml ml XX cord-006856-b1w25ob5 698 11 in in IN cord-006856-b1w25ob5 698 12 the the DT cord-006856-b1w25ob5 698 13 middle middle NN cord-006856-b1w25ob5 698 14 of of IN cord-006856-b1w25ob5 698 15 the the DT cord-006856-b1w25ob5 698 16 observation observation NN cord-006856-b1w25ob5 698 17 period period NN cord-006856-b1w25ob5 698 18 correlated correlate VBD cord-006856-b1w25ob5 698 19 to to IN cord-006856-b1w25ob5 698 20 a a DT cord-006856-b1w25ob5 698 21 significantly significantly RB cord-006856-b1w25ob5 698 22 decreased decrease VBN cord-006856-b1w25ob5 698 23 one one CD cord-006856-b1w25ob5 698 24 - - HYPH cord-006856-b1w25ob5 698 25 year year NN cord-006856-b1w25ob5 698 26 graft graft NN cord-006856-b1w25ob5 698 27 survival survival NN cord-006856-b1w25ob5 698 28 ( ( -LRB- cord-006856-b1w25ob5 698 29 54 54 CD cord-006856-b1w25ob5 698 30 % % NN cord-006856-b1w25ob5 698 31 vs. vs. NN cord-006856-b1w25ob5 698 32 85 85 CD cord-006856-b1w25ob5 698 33 % % NN cord-006856-b1w25ob5 698 34 ) ) -RRB- cord-006856-b1w25ob5 698 35 . . . cord-006856-b1w25ob5 699 1 Similar Similar NNP cord-006856-b1w25ob5 699 2 was be VBD cord-006856-b1w25ob5 699 3 the the DT cord-006856-b1w25ob5 699 4 course course NN cord-006856-b1w25ob5 699 5 of of IN cord-006856-b1w25ob5 699 6 TGFa TGFa NNS cord-006856-b1w25ob5 699 7 . . . cord-006856-b1w25ob5 700 1 An an DT cord-006856-b1w25ob5 700 2 increase increase NN cord-006856-b1w25ob5 700 3 from from IN cord-006856-b1w25ob5 700 4 the the DT cord-006856-b1w25ob5 700 5 median median JJ cord-006856-b1w25ob5 700 6 concentration concentration NN cord-006856-b1w25ob5 700 7 of of IN cord-006856-b1w25ob5 700 8 39 39 CD cord-006856-b1w25ob5 700 9 pg pg NN cord-006856-b1w25ob5 700 10 / / SYM cord-006856-b1w25ob5 700 11 ml ml NN cord-006856-b1w25ob5 700 12 to to IN cord-006856-b1w25ob5 700 13 levels level NNS cord-006856-b1w25ob5 700 14 above above IN cord-006856-b1w25ob5 700 15 80 80 CD cord-006856-b1w25ob5 700 16 pg pg NN cord-006856-b1w25ob5 700 17 / / SYM cord-006856-b1w25ob5 700 18 ml ml NNS cord-006856-b1w25ob5 700 19 was be VBD cord-006856-b1w25ob5 700 20 observed observe VBN cord-006856-b1w25ob5 700 21 in in IN cord-006856-b1w25ob5 700 22 the the DT cord-006856-b1w25ob5 700 23 context context NN cord-006856-b1w25ob5 700 24 of of IN cord-006856-b1w25ob5 700 25 a a DT cord-006856-b1w25ob5 700 26 decreased decreased JJ cord-006856-b1w25ob5 700 27 primary primary JJ cord-006856-b1w25ob5 700 28 function function NN cord-006856-b1w25ob5 700 29 . . . cord-006856-b1w25ob5 701 1 Regarding regard VBG cord-006856-b1w25ob5 701 2 VEGF VEGF NNP cord-006856-b1w25ob5 701 3 , , , cord-006856-b1w25ob5 701 4 an an DT cord-006856-b1w25ob5 701 5 almost almost RB cord-006856-b1w25ob5 701 6 linear linear JJ cord-006856-b1w25ob5 701 7 increase increase NN cord-006856-b1w25ob5 701 8 of of IN cord-006856-b1w25ob5 701 9 the the DT cord-006856-b1w25ob5 701 10 concentration concentration NN cord-006856-b1w25ob5 701 11 from from IN cord-006856-b1w25ob5 701 12 60 60 CD cord-006856-b1w25ob5 701 13 pg pg NN cord-006856-b1w25ob5 701 14 / / SYM cord-006856-b1w25ob5 701 15 ml ml NN cord-006856-b1w25ob5 701 16 via via IN cord-006856-b1w25ob5 701 17 177 177 CD cord-006856-b1w25ob5 701 18 pg pg NN cord-006856-b1w25ob5 701 19 / / SYM cord-006856-b1w25ob5 701 20 ml ml NN cord-006856-b1w25ob5 701 21 to to IN cord-006856-b1w25ob5 701 22 424 424 CD cord-006856-b1w25ob5 701 23 pg pg NNS cord-006856-b1w25ob5 701 24 / / SYM cord-006856-b1w25ob5 701 25 ml ml NN cord-006856-b1w25ob5 701 26 ( ( -LRB- cord-006856-b1w25ob5 701 27 day day NN cord-006856-b1w25ob5 701 28 1 1 CD cord-006856-b1w25ob5 701 29 , , , cord-006856-b1w25ob5 701 30 7 7 CD cord-006856-b1w25ob5 701 31 , , , cord-006856-b1w25ob5 701 32 and and CC cord-006856-b1w25ob5 701 33 14 14 CD cord-006856-b1w25ob5 701 34 ) ) -RRB- cord-006856-b1w25ob5 701 35 was be VBD cord-006856-b1w25ob5 701 36 observed observe VBN cord-006856-b1w25ob5 701 37 . . . cord-006856-b1w25ob5 702 1 Here here RB cord-006856-b1w25ob5 702 2 it -PRON- PRP cord-006856-b1w25ob5 702 3 became become VBD cord-006856-b1w25ob5 702 4 obvious obvious JJ cord-006856-b1w25ob5 702 5 , , , cord-006856-b1w25ob5 702 6 that that IN cord-006856-b1w25ob5 702 7 an an DT cord-006856-b1w25ob5 702 8 extensive extensive JJ cord-006856-b1w25ob5 702 9 increase increase NN cord-006856-b1w25ob5 702 10 of of IN cord-006856-b1w25ob5 702 11 the the DT cord-006856-b1w25ob5 702 12 VEGF VEGF NNP cord-006856-b1w25ob5 702 13 concentration concentration NN cord-006856-b1w25ob5 702 14 correlated correlate VBD cord-006856-b1w25ob5 702 15 to to IN cord-006856-b1w25ob5 702 16 a a DT cord-006856-b1w25ob5 702 17 good good JJ cord-006856-b1w25ob5 702 18 transplant transplant NN cord-006856-b1w25ob5 702 19 function function NN cord-006856-b1w25ob5 702 20 . . . cord-006856-b1w25ob5 703 1 Under under IN cord-006856-b1w25ob5 703 2 the the DT cord-006856-b1w25ob5 703 3 premise premise NN cord-006856-b1w25ob5 703 4 that that IN cord-006856-b1w25ob5 703 5 the the DT cord-006856-b1w25ob5 703 6 systemically systemically RB cord-006856-b1w25ob5 703 7 determined determine VBN cord-006856-b1w25ob5 703 8 concentrations concentration NNS cord-006856-b1w25ob5 703 9 were be VBD cord-006856-b1w25ob5 703 10 in in IN cord-006856-b1w25ob5 703 11 relevant relevant JJ cord-006856-b1w25ob5 703 12 correlation correlation NN cord-006856-b1w25ob5 703 13 to to IN cord-006856-b1w25ob5 703 14 the the DT cord-006856-b1w25ob5 703 15 secretion secretion NN cord-006856-b1w25ob5 703 16 and and CC cord-006856-b1w25ob5 703 17 thus thus RB cord-006856-b1w25ob5 703 18 to to IN cord-006856-b1w25ob5 703 19 the the DT cord-006856-b1w25ob5 703 20 local local JJ cord-006856-b1w25ob5 703 21 concentration concentration NN cord-006856-b1w25ob5 703 22 in in IN cord-006856-b1w25ob5 703 23 the the DT cord-006856-b1w25ob5 703 24 liver liver NN cord-006856-b1w25ob5 703 25 , , , cord-006856-b1w25ob5 703 26 it -PRON- PRP cord-006856-b1w25ob5 703 27 can can MD cord-006856-b1w25ob5 703 28 be be VB cord-006856-b1w25ob5 703 29 concluded conclude VBN cord-006856-b1w25ob5 703 30 that that IN cord-006856-b1w25ob5 703 31 vascular vascular JJ cord-006856-b1w25ob5 703 32 regeneration regeneration NN cord-006856-b1w25ob5 703 33 induced induce VBN cord-006856-b1w25ob5 703 34 by by IN cord-006856-b1w25ob5 703 35 VEGF VEGF NNP cord-006856-b1w25ob5 703 36 substantially substantially RB cord-006856-b1w25ob5 703 37 contributes contribute VBZ cord-006856-b1w25ob5 703 38 to to TO cord-006856-b1w25ob5 703 39 graft graft NN cord-006856-b1w25ob5 703 40 survival survival NN cord-006856-b1w25ob5 703 41 , , , cord-006856-b1w25ob5 703 42 whereas whereas IN cord-006856-b1w25ob5 703 43 a a DT cord-006856-b1w25ob5 703 44 temporal temporal JJ cord-006856-b1w25ob5 703 45 increase increase NN cord-006856-b1w25ob5 703 46 of of IN cord-006856-b1w25ob5 703 47 HGF HGF NNP cord-006856-b1w25ob5 703 48 and and CC cord-006856-b1w25ob5 703 49 TGFa TGFa NNS cord-006856-b1w25ob5 703 50 rather rather RB cord-006856-b1w25ob5 703 51 has have VBZ cord-006856-b1w25ob5 703 52 to to TO cord-006856-b1w25ob5 703 53 be be VB cord-006856-b1w25ob5 703 54 interpreted interpret VBN cord-006856-b1w25ob5 703 55 as as IN cord-006856-b1w25ob5 703 56 an an DT cord-006856-b1w25ob5 703 57 indicator indicator NN cord-006856-b1w25ob5 703 58 of of IN cord-006856-b1w25ob5 703 59 an an DT cord-006856-b1w25ob5 703 60 injured injure VBN cord-006856-b1w25ob5 703 61 graft graft NN cord-006856-b1w25ob5 703 62 with with IN cord-006856-b1w25ob5 703 63 a a DT cord-006856-b1w25ob5 703 64 decreased decrease VBN cord-006856-b1w25ob5 703 65 functional functional JJ cord-006856-b1w25ob5 703 66 prognosis prognosis NN cord-006856-b1w25ob5 703 67 . . . cord-006856-b1w25ob5 704 1 In in IN cord-006856-b1w25ob5 704 2 total total NN cord-006856-b1w25ob5 704 3 there there EX cord-006856-b1w25ob5 704 4 are be VBP cord-006856-b1w25ob5 704 5 about about RB cord-006856-b1w25ob5 704 6 1650 1650 CD cord-006856-b1w25ob5 704 7 patients patient NNS cord-006856-b1w25ob5 704 8 on on IN cord-006856-b1w25ob5 704 9 dialysis dialysis NN cord-006856-b1w25ob5 704 10 in in IN cord-006856-b1w25ob5 704 11 BH bh NN cord-006856-b1w25ob5 704 12 and and CC cord-006856-b1w25ob5 704 13 percentage percentage NN cord-006856-b1w25ob5 704 14 of of IN cord-006856-b1w25ob5 704 15 transplanted transplant VBN cord-006856-b1w25ob5 704 16 is be VBZ cord-006856-b1w25ob5 704 17 9.24 9.24 CD cord-006856-b1w25ob5 704 18 . . . cord-006856-b1w25ob5 705 1 The the DT cord-006856-b1w25ob5 705 2 aim aim NN cord-006856-b1w25ob5 705 3 of of IN cord-006856-b1w25ob5 705 4 the the DT cord-006856-b1w25ob5 705 5 paper paper NN cord-006856-b1w25ob5 705 6 is be VBZ cord-006856-b1w25ob5 705 7 to to TO cord-006856-b1w25ob5 705 8 analyse analyse VB cord-006856-b1w25ob5 705 9 survival survival NN cord-006856-b1w25ob5 705 10 of of IN cord-006856-b1w25ob5 705 11 grafts graft NNS cord-006856-b1w25ob5 705 12 , , , cord-006856-b1w25ob5 705 13 patients patient NNS cord-006856-b1w25ob5 705 14 , , , cord-006856-b1w25ob5 705 15 and and CC cord-006856-b1w25ob5 705 16 grafts graft NNS cord-006856-b1w25ob5 705 17 and and CC cord-006856-b1w25ob5 705 18 patients patient NNS cord-006856-b1w25ob5 705 19 over over IN cord-006856-b1w25ob5 705 20 a a DT cord-006856-b1w25ob5 705 21 5-year 5-year CD cord-006856-b1w25ob5 705 22 period period NN cord-006856-b1w25ob5 705 23 of of IN cord-006856-b1w25ob5 705 24 living living NN cord-006856-b1w25ob5 705 25 - - HYPH cord-006856-b1w25ob5 705 26 related relate VBN cord-006856-b1w25ob5 705 27 kidney kidney NN cord-006856-b1w25ob5 705 28 transplantation transplantation NN cord-006856-b1w25ob5 705 29 history history NN cord-006856-b1w25ob5 705 30 at at IN cord-006856-b1w25ob5 705 31 University University NNP cord-006856-b1w25ob5 705 32 Medical Medical NNP cord-006856-b1w25ob5 705 33 Center Center NNP cord-006856-b1w25ob5 705 34 Tuzla Tuzla NNP cord-006856-b1w25ob5 705 35 . . . cord-006856-b1w25ob5 706 1 The the DT cord-006856-b1w25ob5 706 2 results result NNS cord-006856-b1w25ob5 706 3 obtained obtain VBN cord-006856-b1w25ob5 706 4 were be VBD cord-006856-b1w25ob5 706 5 compared compare VBN cord-006856-b1w25ob5 706 6 with with IN cord-006856-b1w25ob5 706 7 the the DT cord-006856-b1w25ob5 706 8 results result NNS cord-006856-b1w25ob5 706 9 of of IN cord-006856-b1w25ob5 706 10 the the DT cord-006856-b1w25ob5 706 11 centers center NNS cord-006856-b1w25ob5 706 12 with with IN cord-006856-b1w25ob5 706 13 great great JJ cord-006856-b1w25ob5 706 14 number number NN cord-006856-b1w25ob5 706 15 of of IN cord-006856-b1w25ob5 706 16 transplants transplant NNS cord-006856-b1w25ob5 706 17 . . . cord-006856-b1w25ob5 707 1 Methods method NNS cord-006856-b1w25ob5 707 2 . . . cord-006856-b1w25ob5 708 1 Recipients recipient NNS cord-006856-b1w25ob5 708 2 and and CC cord-006856-b1w25ob5 708 3 donors donor NNS cord-006856-b1w25ob5 708 4 as as IN cord-006856-b1w25ob5 708 5 family family NN cord-006856-b1w25ob5 708 6 members member NNS cord-006856-b1w25ob5 708 7 were be VBD cord-006856-b1w25ob5 708 8 admitted admit VBN cord-006856-b1w25ob5 708 9 after after IN cord-006856-b1w25ob5 708 10 informative informative JJ cord-006856-b1w25ob5 708 11 discussions discussion NNS cord-006856-b1w25ob5 708 12 and and CC cord-006856-b1w25ob5 708 13 after after IN cord-006856-b1w25ob5 708 14 the the DT cord-006856-b1w25ob5 708 15 test test NN cord-006856-b1w25ob5 708 16 results result NNS cord-006856-b1w25ob5 708 17 had have VBD cord-006856-b1w25ob5 708 18 been be VBN cord-006856-b1w25ob5 708 19 obtained obtain VBN cord-006856-b1w25ob5 708 20 from from IN cord-006856-b1w25ob5 708 21 primary primary JJ cord-006856-b1w25ob5 708 22 health health NN cord-006856-b1w25ob5 708 23 care care NN cord-006856-b1w25ob5 708 24 laboratories laboratory NNS cord-006856-b1w25ob5 708 25 . . . cord-006856-b1w25ob5 709 1 The the DT cord-006856-b1w25ob5 709 2 protocol protocol NN cord-006856-b1w25ob5 709 3 was be VBD cord-006856-b1w25ob5 709 4 the the DT cord-006856-b1w25ob5 709 5 standard standard JJ cord-006856-b1w25ob5 709 6 one one NN cord-006856-b1w25ob5 709 7 , , , cord-006856-b1w25ob5 709 8 in in IN cord-006856-b1w25ob5 709 9 accordance accordance NN cord-006856-b1w25ob5 709 10 with with IN cord-006856-b1w25ob5 709 11 the the DT cord-006856-b1w25ob5 709 12 recommendations recommendation NNS cord-006856-b1w25ob5 709 13 of of IN cord-006856-b1w25ob5 709 14 Esot Esot NNP cord-006856-b1w25ob5 709 15 and and CC cord-006856-b1w25ob5 709 16 Eurotransplant Eurotransplant NNP cord-006856-b1w25ob5 709 17 . . . cord-006856-b1w25ob5 710 1 Donors donor NNS cord-006856-b1w25ob5 710 2 were be VBD cord-006856-b1w25ob5 710 3 tested test VBN cord-006856-b1w25ob5 710 4 first first RB cord-006856-b1w25ob5 710 5 and and CC cord-006856-b1w25ob5 710 6 then then RB cord-006856-b1w25ob5 710 7 recipients recipient NNS cord-006856-b1w25ob5 710 8 . . . cord-006856-b1w25ob5 711 1 Lumbotomy Lumbotomy NNP cord-006856-b1w25ob5 711 2 was be VBD cord-006856-b1w25ob5 711 3 done do VBN cord-006856-b1w25ob5 711 4 for for IN cord-006856-b1w25ob5 711 5 nephrectomy nephrectomy NN cord-006856-b1w25ob5 711 6 . . . cord-006856-b1w25ob5 712 1 Colins Colins NNP cord-006856-b1w25ob5 712 2 solution solution NN cord-006856-b1w25ob5 712 3 was be VBD cord-006856-b1w25ob5 712 4 used use VBN cord-006856-b1w25ob5 712 5 for for IN cord-006856-b1w25ob5 712 6 kidney kidney NN cord-006856-b1w25ob5 712 7 rinsing rinsing NN cord-006856-b1w25ob5 712 8 and and CC cord-006856-b1w25ob5 712 9 perfusion perfusion NN cord-006856-b1w25ob5 712 10 , , , cord-006856-b1w25ob5 712 11 reconstruction reconstruction NN cord-006856-b1w25ob5 712 12 of of IN cord-006856-b1w25ob5 712 13 blood blood NN cord-006856-b1w25ob5 712 14 vessels vessel NNS cord-006856-b1w25ob5 712 15 was be VBD cord-006856-b1w25ob5 712 16 done do VBN cord-006856-b1w25ob5 712 17 as as RB cord-006856-b1w25ob5 712 18 well well RB cord-006856-b1w25ob5 712 19 as as IN cord-006856-b1w25ob5 712 20 kidney kidney NN cord-006856-b1w25ob5 712 21 biopsy biopsy NN cord-006856-b1w25ob5 712 22 . . . cord-006856-b1w25ob5 713 1 Then then RB cord-006856-b1w25ob5 713 2 , , , cord-006856-b1w25ob5 713 3 kidneys kidney NNS cord-006856-b1w25ob5 713 4 were be VBD cord-006856-b1w25ob5 713 5 stored store VBN cord-006856-b1w25ob5 713 6 at at IN cord-006856-b1w25ob5 713 7 +4 +4 HYPH cord-006856-b1w25ob5 713 8 ° ° NN cord-006856-b1w25ob5 713 9 C c NN cord-006856-b1w25ob5 713 10 and and CC cord-006856-b1w25ob5 713 11 grafts graft NNS cord-006856-b1w25ob5 713 12 implantations implantation NNS cord-006856-b1w25ob5 713 13 were be VBD cord-006856-b1w25ob5 713 14 done do VBN cord-006856-b1w25ob5 713 15 on on IN cord-006856-b1w25ob5 713 16 the the DT cord-006856-b1w25ob5 713 17 contralateral contralateral JJ cord-006856-b1w25ob5 713 18 iliac iliac JJ cord-006856-b1w25ob5 713 19 fossa fossa NN cord-006856-b1w25ob5 713 20 . . . cord-006856-b1w25ob5 714 1 Terminolateral Terminolateral NNP cord-006856-b1w25ob5 714 2 anastomosis anastomosis NN cord-006856-b1w25ob5 714 3 between between IN cord-006856-b1w25ob5 714 4 external external JJ cord-006856-b1w25ob5 714 5 iliac iliac NN cord-006856-b1w25ob5 714 6 artery artery NN cord-006856-b1w25ob5 714 7 and and CC cord-006856-b1w25ob5 714 8 vein vein NN cord-006856-b1w25ob5 714 9 was be VBD cord-006856-b1w25ob5 714 10 done do VBN cord-006856-b1w25ob5 714 11 . . . cord-006856-b1w25ob5 715 1 Implantation implantation NN cord-006856-b1w25ob5 715 2 of of IN cord-006856-b1w25ob5 715 3 ureters ureter NNS cord-006856-b1w25ob5 715 4 was be VBD cord-006856-b1w25ob5 715 5 done do VBN cord-006856-b1w25ob5 715 6 by by IN cord-006856-b1w25ob5 715 7 modified modify VBN cord-006856-b1w25ob5 715 8 Lich Lich NNP cord-006856-b1w25ob5 715 9 - - HYPH cord-006856-b1w25ob5 715 10 Gregore Gregore NNP cord-006856-b1w25ob5 715 11 technic technic NN cord-006856-b1w25ob5 715 12 , , , cord-006856-b1w25ob5 715 13 with with IN cord-006856-b1w25ob5 715 14 or or CC cord-006856-b1w25ob5 715 15 without without IN cord-006856-b1w25ob5 715 16 DJ DJ NNP cord-006856-b1w25ob5 715 17 stent stent NN cord-006856-b1w25ob5 715 18 . . . cord-006856-b1w25ob5 716 1 All all DT cord-006856-b1w25ob5 716 2 patients patient NNS cord-006856-b1w25ob5 716 3 received receive VBD cord-006856-b1w25ob5 716 4 basic basic JJ cord-006856-b1w25ob5 716 5 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 716 6 protocol protocol NN cord-006856-b1w25ob5 716 7 . . . cord-006856-b1w25ob5 717 1 The the DT cord-006856-b1w25ob5 717 2 peculiarity peculiarity NN cord-006856-b1w25ob5 717 3 was be VBD cord-006856-b1w25ob5 717 4 introduction introduction NN cord-006856-b1w25ob5 717 5 of of IN cord-006856-b1w25ob5 717 6 Basiliximab Basiliximab NNP cord-006856-b1w25ob5 717 7 ( ( -LRB- cord-006856-b1w25ob5 717 8 Simulect Simulect NNP cord-006856-b1w25ob5 717 9 ) ) -RRB- cord-006856-b1w25ob5 717 10 in in IN cord-006856-b1w25ob5 717 11 therapy therapy NN cord-006856-b1w25ob5 717 12 on on IN cord-006856-b1w25ob5 717 13 the the DT cord-006856-b1w25ob5 717 14 first first JJ cord-006856-b1w25ob5 717 15 and and CC cord-006856-b1w25ob5 717 16 fourth fourth JJ cord-006856-b1w25ob5 717 17 postoperative postoperative JJ cord-006856-b1w25ob5 717 18 day day NN cord-006856-b1w25ob5 717 19 . . . cord-006856-b1w25ob5 718 1 Descriptive descriptive JJ cord-006856-b1w25ob5 718 2 statistics statistic NNS cord-006856-b1w25ob5 718 3 was be VBD cord-006856-b1w25ob5 718 4 done do VBN cord-006856-b1w25ob5 718 5 using use VBG cord-006856-b1w25ob5 718 6 SPSS SPSS NNP cord-006856-b1w25ob5 718 7 software software NN cord-006856-b1w25ob5 718 8 for for IN cord-006856-b1w25ob5 718 9 Windows Windows NNP cord-006856-b1w25ob5 718 10 8.0 8.0 CD cord-006856-b1w25ob5 718 11 . . . cord-006856-b1w25ob5 719 1 Survival survival NN cord-006856-b1w25ob5 719 2 is be VBZ cord-006856-b1w25ob5 719 3 presented present VBN cord-006856-b1w25ob5 719 4 by by IN cord-006856-b1w25ob5 719 5 Kaplan Kaplan NNP cord-006856-b1w25ob5 719 6 - - HYPH cord-006856-b1w25ob5 719 7 Meier Meier NNP cord-006856-b1w25ob5 719 8 curve curve NN cord-006856-b1w25ob5 719 9 . . . cord-006856-b1w25ob5 720 1 Results result NNS cord-006856-b1w25ob5 720 2 are be VBP cord-006856-b1w25ob5 720 3 shown show VBN cord-006856-b1w25ob5 720 4 as as IN cord-006856-b1w25ob5 720 5 means mean NNS cord-006856-b1w25ob5 720 6 with with IN cord-006856-b1w25ob5 720 7 standard standard JJ cord-006856-b1w25ob5 720 8 deviations deviation NNS cord-006856-b1w25ob5 720 9 ( ( -LRB- cord-006856-b1w25ob5 720 10 SD SD NNP cord-006856-b1w25ob5 720 11 ) ) -RRB- cord-006856-b1w25ob5 720 12 . . . cord-006856-b1w25ob5 721 1 Results result NNS cord-006856-b1w25ob5 721 2 . . . cord-006856-b1w25ob5 722 1 The the DT cord-006856-b1w25ob5 722 2 first first JJ cord-006856-b1w25ob5 722 3 living living NN cord-006856-b1w25ob5 722 4 - - HYPH cord-006856-b1w25ob5 722 5 related relate VBN cord-006856-b1w25ob5 722 6 kidney kidney NN cord-006856-b1w25ob5 722 7 transplantation transplantation NN cord-006856-b1w25ob5 722 8 was be VBD cord-006856-b1w25ob5 722 9 done do VBN cord-006856-b1w25ob5 722 10 at at IN cord-006856-b1w25ob5 722 11 University University NNP cord-006856-b1w25ob5 722 12 Medical Medical NNP cord-006856-b1w25ob5 722 13 Center Center NNP cord-006856-b1w25ob5 722 14 Tuzla Tuzla NNP cord-006856-b1w25ob5 722 15 on on IN cord-006856-b1w25ob5 722 16 15 15 CD cord-006856-b1w25ob5 722 17 . . . cord-006856-b1w25ob5 723 1 09.1999 09.1999 CD cord-006856-b1w25ob5 723 2 09 09 CD cord-006856-b1w25ob5 723 3 . . . cord-006856-b1w25ob5 723 4 . . . cord-006856-b1w25ob5 724 1 Until until IN cord-006856-b1w25ob5 724 2 15.09.2004 15.09.2004 CD cord-006856-b1w25ob5 724 3 . . . cord-006856-b1w25ob5 725 1 as as RB cord-006856-b1w25ob5 725 2 many many JJ cord-006856-b1w25ob5 725 3 as as IN cord-006856-b1w25ob5 725 4 52 52 CD cord-006856-b1w25ob5 725 5 transplants transplant NNS cord-006856-b1w25ob5 725 6 have have VBP cord-006856-b1w25ob5 725 7 been be VBN cord-006856-b1w25ob5 725 8 done do VBN cord-006856-b1w25ob5 725 9 . . . cord-006856-b1w25ob5 726 1 Donors donor NNS cord-006856-b1w25ob5 726 2 were be VBD cord-006856-b1w25ob5 726 3 related relate VBN cord-006856-b1w25ob5 726 4 to to IN cord-006856-b1w25ob5 726 5 recipients recipient NNS cord-006856-b1w25ob5 726 6 as as IN cord-006856-b1w25ob5 726 7 follows follow VBZ cord-006856-b1w25ob5 726 8 ( ( -LRB- cord-006856-b1w25ob5 726 9 in in IN cord-006856-b1w25ob5 726 10 parentheses parenthesis NNS cord-006856-b1w25ob5 726 11 , , , cord-006856-b1w25ob5 726 12 mean mean VB cord-006856-b1w25ob5 726 13 age age NN cord-006856-b1w25ob5 726 14 [ [ -LRB- cord-006856-b1w25ob5 726 15 years year NNS cord-006856-b1w25ob5 726 16 ] ] -RRB- cord-006856-b1w25ob5 726 17 with with IN cord-006856-b1w25ob5 726 18 SD sd NN cord-006856-b1w25ob5 726 19 ) ) -RRB- cord-006856-b1w25ob5 726 20 : : : cord-006856-b1w25ob5 727 1 mother mother NN cord-006856-b1w25ob5 727 2 , , , cord-006856-b1w25ob5 727 3 n n NN cord-006856-b1w25ob5 727 4 = = SYM cord-006856-b1w25ob5 727 5 24 24 CD cord-006856-b1w25ob5 727 6 ( ( -LRB- cord-006856-b1w25ob5 727 7 55.0 55.0 CD cord-006856-b1w25ob5 727 8 ± ± NNP cord-006856-b1w25ob5 727 9 11.3 11.3 CD cord-006856-b1w25ob5 727 10 ) ) -RRB- cord-006856-b1w25ob5 727 11 ; ; : cord-006856-b1w25ob5 727 12 father father NNP cord-006856-b1w25ob5 727 13 , , , cord-006856-b1w25ob5 727 14 n n NN cord-006856-b1w25ob5 727 15 = = SYM cord-006856-b1w25ob5 727 16 15 15 CD cord-006856-b1w25ob5 727 17 ( ( -LRB- cord-006856-b1w25ob5 727 18 61.4 61.4 CD cord-006856-b1w25ob5 727 19 ± ± CD cord-006856-b1w25ob5 727 20 6.9 6.9 CD cord-006856-b1w25ob5 727 21 ) ) -RRB- cord-006856-b1w25ob5 727 22 ; ; : cord-006856-b1w25ob5 727 23 sister sister NN cord-006856-b1w25ob5 727 24 , , , cord-006856-b1w25ob5 727 25 5 5 CD cord-006856-b1w25ob5 727 26 ( ( -LRB- cord-006856-b1w25ob5 727 27 44.5 44.5 CD cord-006856-b1w25ob5 727 28 ± ± CD cord-006856-b1w25ob5 727 29 6.4 6.4 CD cord-006856-b1w25ob5 727 30 ) ) -RRB- cord-006856-b1w25ob5 727 31 ; ; : cord-006856-b1w25ob5 727 32 brother brother NN cord-006856-b1w25ob5 727 33 , , , cord-006856-b1w25ob5 727 34 n n NN cord-006856-b1w25ob5 727 35 = = SYM cord-006856-b1w25ob5 727 36 6 6 CD cord-006856-b1w25ob5 727 37 ( ( -LRB- cord-006856-b1w25ob5 727 38 46.0 46.0 CD cord-006856-b1w25ob5 727 39 ± ± CD cord-006856-b1w25ob5 727 40 2.9 2.9 CD cord-006856-b1w25ob5 727 41 ) ) -RRB- cord-006856-b1w25ob5 727 42 ; ; : cord-006856-b1w25ob5 727 43 others other NNS cord-006856-b1w25ob5 727 44 , , , cord-006856-b1w25ob5 727 45 n n NN cord-006856-b1w25ob5 727 46 = = SYM cord-006856-b1w25ob5 727 47 2 2 CD cord-006856-b1w25ob5 727 48 ( ( -LRB- cord-006856-b1w25ob5 727 49 38.5 38.5 CD cord-006856-b1w25ob5 727 50 ± ± CD cord-006856-b1w25ob5 727 51 5.5 5.5 CD cord-006856-b1w25ob5 727 52 ) ) -RRB- cord-006856-b1w25ob5 727 53 . . . cord-006856-b1w25ob5 728 1 Table table NN cord-006856-b1w25ob5 728 2 1 1 CD cord-006856-b1w25ob5 728 3 shows show NNS cord-006856-b1w25ob5 728 4 mean mean VBP cord-006856-b1w25ob5 728 5 DTPA DTPA NNP cord-006856-b1w25ob5 728 6 clearance clearance NN cord-006856-b1w25ob5 728 7 rate rate NN cord-006856-b1w25ob5 728 8 in in IN cord-006856-b1w25ob5 728 9 donors donor NNS cord-006856-b1w25ob5 728 10 . . . cord-006856-b1w25ob5 729 1 Average average JJ cord-006856-b1w25ob5 729 2 separate separate JJ cord-006856-b1w25ob5 729 3 DTPA dtpa NN cord-006856-b1w25ob5 729 4 clearance clearance NN cord-006856-b1w25ob5 729 5 rates rate NNS cord-006856-b1w25ob5 729 6 were be VBD cord-006856-b1w25ob5 729 7 within within IN cord-006856-b1w25ob5 729 8 normal normal JJ cord-006856-b1w25ob5 729 9 limits limit NNS cord-006856-b1w25ob5 729 10 . . . cord-006856-b1w25ob5 730 1 As as IN cord-006856-b1w25ob5 730 2 a a DT cord-006856-b1w25ob5 730 3 rule rule NN cord-006856-b1w25ob5 730 4 , , , cord-006856-b1w25ob5 730 5 left left JJ cord-006856-b1w25ob5 730 6 - - HYPH cord-006856-b1w25ob5 730 7 side side NN cord-006856-b1w25ob5 730 8 donor donor NN cord-006856-b1w25ob5 730 9 nephrectomy nephrectomy NN cord-006856-b1w25ob5 730 10 was be VBD cord-006856-b1w25ob5 730 11 done do VBN cord-006856-b1w25ob5 730 12 ; ; : cord-006856-b1w25ob5 730 13 and and CC cord-006856-b1w25ob5 730 14 in in IN cord-006856-b1w25ob5 730 15 five five CD cord-006856-b1w25ob5 730 16 cases case NNS cord-006856-b1w25ob5 730 17 , , , cord-006856-b1w25ob5 730 18 right right JJ cord-006856-b1w25ob5 730 19 - - HYPH cord-006856-b1w25ob5 730 20 side side NN cord-006856-b1w25ob5 730 21 nephrectomy nephrectomy NN cord-006856-b1w25ob5 730 22 . . . cord-006856-b1w25ob5 731 1 Three three CD cord-006856-b1w25ob5 731 2 donors donor NNS cord-006856-b1w25ob5 731 3 showed show VBD cord-006856-b1w25ob5 731 4 borderline borderline JJ cord-006856-b1w25ob5 731 5 DTPA DTPA NNP cord-006856-b1w25ob5 731 6 clearance clearance NN cord-006856-b1w25ob5 731 7 rates rate NNS cord-006856-b1w25ob5 731 8 of of IN cord-006856-b1w25ob5 731 9 about about RB cord-006856-b1w25ob5 731 10 40 40 CD cord-006856-b1w25ob5 731 11 ml ml NNS cord-006856-b1w25ob5 731 12 / / SYM cord-006856-b1w25ob5 731 13 min min NN cord-006856-b1w25ob5 731 14 . . . cord-006856-b1w25ob5 732 1 Bladder bladder NN cord-006856-b1w25ob5 732 2 neck neck NN cord-006856-b1w25ob5 732 3 sclerosis sclerosis NN cord-006856-b1w25ob5 732 4 was be VBD cord-006856-b1w25ob5 732 5 found find VBN cord-006856-b1w25ob5 732 6 in in IN cord-006856-b1w25ob5 732 7 one one CD cord-006856-b1w25ob5 732 8 patient patient NN cord-006856-b1w25ob5 732 9 and and CC cord-006856-b1w25ob5 732 10 the the DT cord-006856-b1w25ob5 732 11 air air NN cord-006856-b1w25ob5 732 12 expansion expansion NN cord-006856-b1w25ob5 732 13 of of IN cord-006856-b1w25ob5 732 14 the the DT cord-006856-b1w25ob5 732 15 bladder bladder NN cord-006856-b1w25ob5 732 16 had have VBD cord-006856-b1w25ob5 732 17 to to TO cord-006856-b1w25ob5 732 18 be be VB cord-006856-b1w25ob5 732 19 done do VBN cord-006856-b1w25ob5 732 20 in in IN cord-006856-b1w25ob5 732 21 the the DT cord-006856-b1w25ob5 732 22 other other JJ cord-006856-b1w25ob5 732 23 one one NN cord-006856-b1w25ob5 732 24 , , , cord-006856-b1w25ob5 732 25 at at IN cord-006856-b1w25ob5 732 26 least least JJS cord-006856-b1w25ob5 732 27 to to TO cord-006856-b1w25ob5 732 28 achieve achieve VB cord-006856-b1w25ob5 732 29 its -PRON- PRP$ cord-006856-b1w25ob5 732 30 minimal minimal JJ cord-006856-b1w25ob5 732 31 capacity capacity NN cord-006856-b1w25ob5 732 32 . . . cord-006856-b1w25ob5 733 1 Two two CD cord-006856-b1w25ob5 733 2 renal renal JJ cord-006856-b1w25ob5 733 3 arteries artery NNS cord-006856-b1w25ob5 733 4 were be VBD cord-006856-b1w25ob5 733 5 found find VBN cord-006856-b1w25ob5 733 6 in in IN cord-006856-b1w25ob5 733 7 5 5 CD cord-006856-b1w25ob5 733 8 patients patient NNS cord-006856-b1w25ob5 733 9 ( ( -LRB- cord-006856-b1w25ob5 733 10 3 3 CD cord-006856-b1w25ob5 733 11 mothers mother NNS cord-006856-b1w25ob5 733 12 , , , cord-006856-b1w25ob5 733 13 1 1 CD cord-006856-b1w25ob5 733 14 father father NN cord-006856-b1w25ob5 733 15 , , , cord-006856-b1w25ob5 733 16 1 1 CD cord-006856-b1w25ob5 733 17 sister sister NN cord-006856-b1w25ob5 733 18 ) ) -RRB- cord-006856-b1w25ob5 733 19 , , , cord-006856-b1w25ob5 733 20 two two CD cord-006856-b1w25ob5 733 21 arteries artery NNS cord-006856-b1w25ob5 733 22 were be VBD cord-006856-b1w25ob5 733 23 found find VBN cord-006856-b1w25ob5 733 24 with with IN cord-006856-b1w25ob5 733 25 left left JJ cord-006856-b1w25ob5 733 26 kidney kidney NN cord-006856-b1w25ob5 733 27 transplantation transplantation NN cord-006856-b1w25ob5 733 28 . . . cord-006856-b1w25ob5 734 1 Termino termino JJ cord-006856-b1w25ob5 734 2 - - HYPH cord-006856-b1w25ob5 734 3 lateral lateral JJ cord-006856-b1w25ob5 734 4 anastomosis anastomosis NN cord-006856-b1w25ob5 734 5 was be VBD cord-006856-b1w25ob5 734 6 done do VBN cord-006856-b1w25ob5 734 7 in in IN cord-006856-b1w25ob5 734 8 2 2 CD cord-006856-b1w25ob5 734 9 cases case NNS cord-006856-b1w25ob5 734 10 . . . cord-006856-b1w25ob5 735 1 The the DT cord-006856-b1w25ob5 735 2 average average JJ cord-006856-b1w25ob5 735 3 age age NN cord-006856-b1w25ob5 735 4 of of IN cord-006856-b1w25ob5 735 5 the the DT cord-006856-b1w25ob5 735 6 donors donor NNS cord-006856-b1w25ob5 735 7 was be VBD cord-006856-b1w25ob5 735 8 51.08 51.08 CD cord-006856-b1w25ob5 735 9 ± ± CD cord-006856-b1w25ob5 735 10 6.58 6.58 CD cord-006856-b1w25ob5 735 11 years year NNS cord-006856-b1w25ob5 735 12 . . . cord-006856-b1w25ob5 736 1 As as RB cord-006856-b1w25ob5 736 2 many many JJ cord-006856-b1w25ob5 736 3 as as IN cord-006856-b1w25ob5 736 4 16 16 CD cord-006856-b1w25ob5 736 5 donors donor NNS cord-006856-b1w25ob5 736 6 were be VBD cord-006856-b1w25ob5 736 7 over over IN cord-006856-b1w25ob5 736 8 60 60 CD cord-006856-b1w25ob5 736 9 years year NNS cord-006856-b1w25ob5 736 10 old old JJ cord-006856-b1w25ob5 736 11 in in IN cord-006856-b1w25ob5 736 12 our -PRON- PRP$ cord-006856-b1w25ob5 736 13 transplants transplant NNS cord-006856-b1w25ob5 736 14 , , , cord-006856-b1w25ob5 736 15 which which WDT cord-006856-b1w25ob5 736 16 reflected reflect VBD cord-006856-b1w25ob5 736 17 in in IN cord-006856-b1w25ob5 736 18 our -PRON- PRP$ cord-006856-b1w25ob5 736 19 results result NNS cord-006856-b1w25ob5 736 20 . . . cord-006856-b1w25ob5 737 1 The the DT cord-006856-b1w25ob5 737 2 average average JJ cord-006856-b1w25ob5 737 3 donor donor NN cord-006856-b1w25ob5 737 4 age age NN cord-006856-b1w25ob5 737 5 of of IN cord-006856-b1w25ob5 737 6 36 36 CD cord-006856-b1w25ob5 737 7 males male NNS cord-006856-b1w25ob5 737 8 and and CC cord-006856-b1w25ob5 737 9 16 16 CD cord-006856-b1w25ob5 737 10 females female NNS cord-006856-b1w25ob5 737 11 was be VBD cord-006856-b1w25ob5 737 12 32.4 32.4 CD cord-006856-b1w25ob5 737 13 ± ± CD cord-006856-b1w25ob5 737 14 8.1 8.1 CD cord-006856-b1w25ob5 737 15 years year NNS cord-006856-b1w25ob5 737 16 . . . cord-006856-b1w25ob5 738 1 The the DT cord-006856-b1w25ob5 738 2 data datum NNS cord-006856-b1w25ob5 738 3 on on IN cord-006856-b1w25ob5 738 4 hypertension hypertension NN cord-006856-b1w25ob5 738 5 before before IN cord-006856-b1w25ob5 738 6 transplants transplant NNS cord-006856-b1w25ob5 738 7 were be VBD cord-006856-b1w25ob5 738 8 not not RB cord-006856-b1w25ob5 738 9 reliable reliable JJ cord-006856-b1w25ob5 738 10 . . . cord-006856-b1w25ob5 739 1 The the DT cord-006856-b1w25ob5 739 2 average average JJ cord-006856-b1w25ob5 739 3 hemodialysis hemodialysis NN cord-006856-b1w25ob5 739 4 time time NN cord-006856-b1w25ob5 739 5 was be VBD cord-006856-b1w25ob5 739 6 21.48 21.48 CD cord-006856-b1w25ob5 739 7 ± ± CD cord-006856-b1w25ob5 739 8 10.36 10.36 CD cord-006856-b1w25ob5 739 9 months month NNS cord-006856-b1w25ob5 739 10 . . . cord-006856-b1w25ob5 740 1 The the DT cord-006856-b1w25ob5 740 2 most most RBS cord-006856-b1w25ob5 740 3 common common JJ cord-006856-b1w25ob5 740 4 recipients recipient NNS cord-006856-b1w25ob5 740 5 ' ' POS cord-006856-b1w25ob5 740 6 diseases disease NNS cord-006856-b1w25ob5 740 7 were be VBD cord-006856-b1w25ob5 740 8 chronic chronic JJ cord-006856-b1w25ob5 740 9 glomerulonephritis glomerulonephritis NN cord-006856-b1w25ob5 740 10 , , , cord-006856-b1w25ob5 740 11 pyelonephritis pyelonephritis NN cord-006856-b1w25ob5 740 12 , , , cord-006856-b1w25ob5 740 13 interstitial interstitial JJ cord-006856-b1w25ob5 740 14 nephritis nephritis NN cord-006856-b1w25ob5 740 15 , , , cord-006856-b1w25ob5 740 16 nondefined nondefine VBN cord-006856-b1w25ob5 740 17 renal renal JJ cord-006856-b1w25ob5 740 18 disease disease NN cord-006856-b1w25ob5 740 19 , , , cord-006856-b1w25ob5 740 20 diabetes diabetes NN cord-006856-b1w25ob5 740 21 mellitus mellitus NN cord-006856-b1w25ob5 740 22 , , , cord-006856-b1w25ob5 740 23 systemic systemic JJ cord-006856-b1w25ob5 740 24 lupus lupus NN cord-006856-b1w25ob5 740 25 , , , cord-006856-b1w25ob5 740 26 vesico vesico NN cord-006856-b1w25ob5 740 27 - - HYPH cord-006856-b1w25ob5 740 28 ureteral ureteral JJ cord-006856-b1w25ob5 740 29 reflux reflux NN cord-006856-b1w25ob5 740 30 . . . cord-006856-b1w25ob5 741 1 There there EX cord-006856-b1w25ob5 741 2 were be VBD cord-006856-b1w25ob5 741 3 only only RB cord-006856-b1w25ob5 741 4 8 8 CD cord-006856-b1w25ob5 741 5 biopsies biopsy NNS cord-006856-b1w25ob5 741 6 done do VBN cord-006856-b1w25ob5 741 7 before before IN cord-006856-b1w25ob5 741 8 transplantation transplantation NN cord-006856-b1w25ob5 741 9 so so IN cord-006856-b1w25ob5 741 10 that that IN cord-006856-b1w25ob5 741 11 their -PRON- PRP$ cord-006856-b1w25ob5 741 12 histological histological JJ cord-006856-b1w25ob5 741 13 background background NN cord-006856-b1w25ob5 741 14 was be VBD cord-006856-b1w25ob5 741 15 known know VBN cord-006856-b1w25ob5 741 16 . . . cord-006856-b1w25ob5 742 1 The the DT cord-006856-b1w25ob5 742 2 average average JJ cord-006856-b1w25ob5 742 3 serum serum NN cord-006856-b1w25ob5 742 4 creatinine creatinine NN cord-006856-b1w25ob5 742 5 after after IN cord-006856-b1w25ob5 742 6 5 5 CD cord-006856-b1w25ob5 742 7 years year NNS cord-006856-b1w25ob5 742 8 is be VBZ cord-006856-b1w25ob5 742 9 153.56 153.56 CD cord-006856-b1w25ob5 742 10 ± ± CD cord-006856-b1w25ob5 742 11 24.65 24.65 CD cord-006856-b1w25ob5 742 12 µmol µmol NNP cord-006856-b1w25ob5 742 13 / / SYM cord-006856-b1w25ob5 742 14 l l NN cord-006856-b1w25ob5 742 15 . . . cord-006856-b1w25ob5 743 1 Cumulative cumulative JJ cord-006856-b1w25ob5 743 2 graft graft NN cord-006856-b1w25ob5 743 3 survival survival NN cord-006856-b1w25ob5 743 4 after after IN cord-006856-b1w25ob5 743 5 5 5 CD cord-006856-b1w25ob5 743 6 years year NNS cord-006856-b1w25ob5 743 7 is be VBZ cord-006856-b1w25ob5 743 8 shown show VBN cord-006856-b1w25ob5 743 9 by by IN cord-006856-b1w25ob5 743 10 Kaplan Kaplan NNP cord-006856-b1w25ob5 743 11 - - HYPH cord-006856-b1w25ob5 743 12 Meier Meier NNP cord-006856-b1w25ob5 743 13 curve curve NN cord-006856-b1w25ob5 743 14 : : : cord-006856-b1w25ob5 743 15 graft graft NN cord-006856-b1w25ob5 743 16 survival survival NN cord-006856-b1w25ob5 743 17 , , , cord-006856-b1w25ob5 743 18 75.1 75.1 CD cord-006856-b1w25ob5 743 19 % % NN cord-006856-b1w25ob5 743 20 ; ; : cord-006856-b1w25ob5 743 21 patients patient NNS cord-006856-b1w25ob5 743 22 survival survival NN cord-006856-b1w25ob5 743 23 , , , cord-006856-b1w25ob5 743 24 83.9 83.9 CD cord-006856-b1w25ob5 743 25 % % NN cord-006856-b1w25ob5 743 26 ; ; , cord-006856-b1w25ob5 743 27 graft graft NN cord-006856-b1w25ob5 743 28 and and CC cord-006856-b1w25ob5 743 29 patients patient NNS cord-006856-b1w25ob5 743 30 survival survival NN cord-006856-b1w25ob5 743 31 , , , cord-006856-b1w25ob5 743 32 67.1 67.1 CD cord-006856-b1w25ob5 743 33 % % NN cord-006856-b1w25ob5 743 34 . . . cord-006856-b1w25ob5 744 1 Conclusions conclusion NNS cord-006856-b1w25ob5 744 2 . . . cord-006856-b1w25ob5 745 1 The the DT cord-006856-b1w25ob5 745 2 results result NNS cord-006856-b1w25ob5 745 3 on on IN cord-006856-b1w25ob5 745 4 5year 5year JJ cord-006856-b1w25ob5 745 5 living live VBG cord-006856-b1w25ob5 745 6 - - HYPH cord-006856-b1w25ob5 745 7 related relate VBN cord-006856-b1w25ob5 745 8 kidney kidney NN cord-006856-b1w25ob5 745 9 transplantation transplantation NN cord-006856-b1w25ob5 745 10 at at IN cord-006856-b1w25ob5 745 11 University University NNP cord-006856-b1w25ob5 745 12 Medical Medical NNP cord-006856-b1w25ob5 745 13 Center Center NNP cord-006856-b1w25ob5 745 14 Tuzla Tuzla NNP cord-006856-b1w25ob5 745 15 , , , cord-006856-b1w25ob5 745 16 Bosnia Bosnia NNP cord-006856-b1w25ob5 745 17 and and CC cord-006856-b1w25ob5 745 18 Herzegovina Herzegovina NNP cord-006856-b1w25ob5 745 19 , , , cord-006856-b1w25ob5 745 20 are be VBP cord-006856-b1w25ob5 745 21 similar similar JJ cord-006856-b1w25ob5 745 22 or or CC cord-006856-b1w25ob5 745 23 identical identical JJ cord-006856-b1w25ob5 745 24 to to IN cord-006856-b1w25ob5 745 25 the the DT cord-006856-b1w25ob5 745 26 results result NNS cord-006856-b1w25ob5 745 27 of of IN cord-006856-b1w25ob5 745 28 the the DT cord-006856-b1w25ob5 745 29 developed develop VBN cord-006856-b1w25ob5 745 30 centers center NNS cord-006856-b1w25ob5 745 31 in in IN cord-006856-b1w25ob5 745 32 the the DT cord-006856-b1w25ob5 745 33 world world NN cord-006856-b1w25ob5 745 34 . . . cord-006856-b1w25ob5 746 1 The the DT cord-006856-b1w25ob5 746 2 existing exist VBG cord-006856-b1w25ob5 746 3 program program NN cord-006856-b1w25ob5 746 4 has have VBZ cord-006856-b1w25ob5 746 5 got get VBN cord-006856-b1w25ob5 746 6 to to TO cord-006856-b1w25ob5 746 7 be be VB cord-006856-b1w25ob5 746 8 improved improve VBN cord-006856-b1w25ob5 746 9 , , , cord-006856-b1w25ob5 746 10 especially especially RB cord-006856-b1w25ob5 746 11 with with IN cord-006856-b1w25ob5 746 12 respect respect NN cord-006856-b1w25ob5 746 13 to to IN cord-006856-b1w25ob5 746 14 the the DT cord-006856-b1w25ob5 746 15 donor donor NN cord-006856-b1w25ob5 746 16 selection selection NN cord-006856-b1w25ob5 746 17 from from IN cord-006856-b1w25ob5 746 18 the the DT cord-006856-b1w25ob5 746 19 standpoint standpoint NN cord-006856-b1w25ob5 746 20 of of IN cord-006856-b1w25ob5 746 21 biological biological JJ cord-006856-b1w25ob5 746 22 and and CC cord-006856-b1w25ob5 746 23 chronological chronological JJ cord-006856-b1w25ob5 746 24 age age NN cord-006856-b1w25ob5 746 25 . . . cord-006856-b1w25ob5 747 1 The the DT cord-006856-b1w25ob5 747 2 experience experience NN cord-006856-b1w25ob5 747 3 gained gain VBD cord-006856-b1w25ob5 747 4 so so RB cord-006856-b1w25ob5 747 5 far far RB cord-006856-b1w25ob5 747 6 is be VBZ cord-006856-b1w25ob5 747 7 the the DT cord-006856-b1w25ob5 747 8 basis basis NN cord-006856-b1w25ob5 747 9 for for IN cord-006856-b1w25ob5 747 10 the the DT cord-006856-b1w25ob5 747 11 development development NN cord-006856-b1w25ob5 747 12 of of IN cord-006856-b1w25ob5 747 13 cadaveric cadaveric JJ cord-006856-b1w25ob5 747 14 kidney kidney NN cord-006856-b1w25ob5 747 15 transplantation transplantation NN cord-006856-b1w25ob5 747 16 in in IN cord-006856-b1w25ob5 747 17 Bosnia Bosnia NNP cord-006856-b1w25ob5 747 18 and and CC cord-006856-b1w25ob5 747 19 Herzegovina Herzegovina NNP cord-006856-b1w25ob5 747 20 . . . cord-006856-b1w25ob5 748 1 Background background NN cord-006856-b1w25ob5 748 2 . . . cord-006856-b1w25ob5 749 1 Shortage shortage NN cord-006856-b1w25ob5 749 2 of of IN cord-006856-b1w25ob5 749 3 available available JJ cord-006856-b1w25ob5 749 4 organs organ NNS cord-006856-b1w25ob5 749 5 has have VBZ cord-006856-b1w25ob5 749 6 increased increase VBN cord-006856-b1w25ob5 749 7 the the DT cord-006856-b1w25ob5 749 8 demand demand NN cord-006856-b1w25ob5 749 9 for for IN cord-006856-b1w25ob5 749 10 living live VBG cord-006856-b1w25ob5 749 11 kidney kidney NN cord-006856-b1w25ob5 749 12 donation donation NN cord-006856-b1w25ob5 749 13 . . . cord-006856-b1w25ob5 750 1 Whereas whereas IN cord-006856-b1w25ob5 750 2 donation donation NN cord-006856-b1w25ob5 750 3 for for IN cord-006856-b1w25ob5 750 4 relatives relative NNS cord-006856-b1w25ob5 750 5 is be VBZ cord-006856-b1w25ob5 750 6 well well RB cord-006856-b1w25ob5 750 7 accepted accept VBN cord-006856-b1w25ob5 750 8 , , , cord-006856-b1w25ob5 750 9 there there EX cord-006856-b1w25ob5 750 10 remains remain VBZ cord-006856-b1w25ob5 750 11 some some DT cord-006856-b1w25ob5 750 12 controversy controversy NN cord-006856-b1w25ob5 750 13 in in IN cord-006856-b1w25ob5 750 14 the the DT cord-006856-b1w25ob5 750 15 setting setting NN cord-006856-b1w25ob5 750 16 of of IN cord-006856-b1w25ob5 750 17 emotionally emotionally RB cord-006856-b1w25ob5 750 18 related relate VBN cord-006856-b1w25ob5 750 19 donation donation NN cord-006856-b1w25ob5 750 20 . . . cord-006856-b1w25ob5 751 1 There there EX cord-006856-b1w25ob5 751 2 might may MD cord-006856-b1w25ob5 751 3 be be VB cord-006856-b1w25ob5 751 4 a a DT cord-006856-b1w25ob5 751 5 survival survival NN cord-006856-b1w25ob5 751 6 benefit benefit NN cord-006856-b1w25ob5 751 7 for for IN cord-006856-b1w25ob5 751 8 grafts graft NNS cord-006856-b1w25ob5 751 9 donated donate VBN cord-006856-b1w25ob5 751 10 by by IN cord-006856-b1w25ob5 751 11 relatives relative NNS cord-006856-b1w25ob5 751 12 due due JJ cord-006856-b1w25ob5 751 13 to to IN cord-006856-b1w25ob5 751 14 better well JJR cord-006856-b1w25ob5 751 15 HLA HLA NNP cord-006856-b1w25ob5 751 16 matching matching NN cord-006856-b1w25ob5 751 17 . . . cord-006856-b1w25ob5 752 1 A a DT cord-006856-b1w25ob5 752 2 retrospective retrospective JJ cord-006856-b1w25ob5 752 3 analysis analysis NN cord-006856-b1w25ob5 752 4 of of IN cord-006856-b1w25ob5 752 5 162 162 CD cord-006856-b1w25ob5 752 6 living live VBG cord-006856-b1w25ob5 752 7 donor donor NN cord-006856-b1w25ob5 752 8 kidney kidney NN cord-006856-b1w25ob5 752 9 transplants transplant NNS cord-006856-b1w25ob5 752 10 which which WDT cord-006856-b1w25ob5 752 11 were be VBD cord-006856-b1w25ob5 752 12 performed perform VBN cord-006856-b1w25ob5 752 13 at at IN cord-006856-b1w25ob5 752 14 the the DT cord-006856-b1w25ob5 752 15 University University NNP cord-006856-b1w25ob5 752 16 Hospital Hospital NNP cord-006856-b1w25ob5 752 17 of of IN cord-006856-b1w25ob5 752 18 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 752 19 was be VBD cord-006856-b1w25ob5 752 20 made make VBN cord-006856-b1w25ob5 752 21 . . . cord-006856-b1w25ob5 753 1 We -PRON- PRP cord-006856-b1w25ob5 753 2 divided divide VBD cord-006856-b1w25ob5 753 3 the the DT cord-006856-b1w25ob5 753 4 transplants transplant NNS cord-006856-b1w25ob5 753 5 in in IN cord-006856-b1w25ob5 753 6 two two CD cord-006856-b1w25ob5 753 7 groups group NNS cord-006856-b1w25ob5 753 8 according accord VBG cord-006856-b1w25ob5 753 9 to to IN cord-006856-b1w25ob5 753 10 the the DT cord-006856-b1w25ob5 753 11 date date NN cord-006856-b1w25ob5 753 12 of of IN cord-006856-b1w25ob5 753 13 transplant transplant NN cord-006856-b1w25ob5 753 14 : : : cord-006856-b1w25ob5 753 15 group group NN cord-006856-b1w25ob5 753 16 1 1 CD cord-006856-b1w25ob5 753 17 ( ( -LRB- cord-006856-b1w25ob5 753 18 1975 1975 CD cord-006856-b1w25ob5 753 19 - - SYM cord-006856-b1w25ob5 753 20 1993 1993 CD cord-006856-b1w25ob5 753 21 ) ) -RRB- cord-006856-b1w25ob5 753 22 , , , cord-006856-b1w25ob5 753 23 41 41 CD cord-006856-b1w25ob5 753 24 transplants transplant NNS cord-006856-b1w25ob5 753 25 ; ; : cord-006856-b1w25ob5 753 26 group group NN cord-006856-b1w25ob5 753 27 2 2 CD cord-006856-b1w25ob5 753 28 ( ( -LRB- cord-006856-b1w25ob5 753 29 1994 1994 CD cord-006856-b1w25ob5 753 30 - - SYM cord-006856-b1w25ob5 753 31 2005 2005 CD cord-006856-b1w25ob5 753 32 ) ) -RRB- cord-006856-b1w25ob5 753 33 , , , cord-006856-b1w25ob5 753 34 89 89 CD cord-006856-b1w25ob5 753 35 transplants transplant NNS cord-006856-b1w25ob5 753 36 . . . cord-006856-b1w25ob5 754 1 The the DT cord-006856-b1w25ob5 754 2 time time NN cord-006856-b1w25ob5 754 3 period period NN cord-006856-b1w25ob5 754 4 from from IN cord-006856-b1w25ob5 754 5 1994 1994 CD cord-006856-b1w25ob5 754 6 until until IN cord-006856-b1w25ob5 754 7 2004 2004 CD cord-006856-b1w25ob5 754 8 was be VBD cord-006856-b1w25ob5 754 9 analyzed analyze VBN cord-006856-b1w25ob5 754 10 in in IN cord-006856-b1w25ob5 754 11 detail detail NN cord-006856-b1w25ob5 754 12 and and CC cord-006856-b1w25ob5 754 13 data data NN cord-006856-b1w25ob5 754 14 additionally additionally RB cord-006856-b1w25ob5 754 15 compared compare VBN cord-006856-b1w25ob5 754 16 to to IN cord-006856-b1w25ob5 754 17 a a DT cord-006856-b1w25ob5 754 18 cohort cohort NN cord-006856-b1w25ob5 754 19 of of IN cord-006856-b1w25ob5 754 20 940 940 CD cord-006856-b1w25ob5 754 21 cadaveric cadaveric JJ cord-006856-b1w25ob5 754 22 renal renal JJ cord-006856-b1w25ob5 754 23 transplants transplant NNS cord-006856-b1w25ob5 754 24 . . . cord-006856-b1w25ob5 755 1 During during IN cord-006856-b1w25ob5 755 2 these these DT cord-006856-b1w25ob5 755 3 eleven eleven CD cord-006856-b1w25ob5 755 4 years year NNS cord-006856-b1w25ob5 755 5 , , , cord-006856-b1w25ob5 755 6 five five CD cord-006856-b1w25ob5 755 7 liv liv NNP cord-006856-b1w25ob5 755 8 - - HYPH cord-006856-b1w25ob5 755 9 ing e VBG cord-006856-b1w25ob5 755 10 donations donation NNS cord-006856-b1w25ob5 755 11 were be VBD cord-006856-b1w25ob5 755 12 carried carry VBN cord-006856-b1w25ob5 755 13 out out RP cord-006856-b1w25ob5 755 14 in in IN cord-006856-b1w25ob5 755 15 patients patient NNS cord-006856-b1w25ob5 755 16 who who WP cord-006856-b1w25ob5 755 17 were be VBD cord-006856-b1w25ob5 755 18 not not RB cord-006856-b1w25ob5 755 19 eligible eligible JJ cord-006856-b1w25ob5 755 20 to to TO cord-006856-b1w25ob5 755 21 receive receive VB cord-006856-b1w25ob5 755 22 a a DT cord-006856-b1w25ob5 755 23 cadaveric cadaveric JJ cord-006856-b1w25ob5 755 24 graft graft NN cord-006856-b1w25ob5 755 25 within within IN cord-006856-b1w25ob5 755 26 Eurotransplant Eurotransplant NNP cord-006856-b1w25ob5 755 27 . . . cord-006856-b1w25ob5 756 1 Results result NNS cord-006856-b1w25ob5 756 2 . . . cord-006856-b1w25ob5 757 1 Overall overall RB cord-006856-b1w25ob5 757 2 there there EX cord-006856-b1w25ob5 757 3 were be VBD cord-006856-b1w25ob5 757 4 128 128 CD cord-006856-b1w25ob5 757 5 LRT LRT NNP cord-006856-b1w25ob5 757 6 ( ( -LRB- cord-006856-b1w25ob5 757 7 53 53 CD cord-006856-b1w25ob5 757 8 siblings sibling NNS cord-006856-b1w25ob5 757 9 , , , cord-006856-b1w25ob5 757 10 70 70 CD cord-006856-b1w25ob5 757 11 parents parent NNS cord-006856-b1w25ob5 757 12 , , , cord-006856-b1w25ob5 757 13 5 5 CD cord-006856-b1w25ob5 757 14 off off IN cord-006856-b1w25ob5 757 15 - - HYPH cord-006856-b1w25ob5 757 16 springs spring NNS cord-006856-b1w25ob5 757 17 ) ) -RRB- cord-006856-b1w25ob5 757 18 and and CC cord-006856-b1w25ob5 757 19 34 34 CD cord-006856-b1w25ob5 757 20 ERT ERT NNP cord-006856-b1w25ob5 757 21 ( ( -LRB- cord-006856-b1w25ob5 757 22 22 22 CD cord-006856-b1w25ob5 757 23 spouses spouse NNS cord-006856-b1w25ob5 757 24 , , , cord-006856-b1w25ob5 757 25 12 12 CD cord-006856-b1w25ob5 757 26 others other NNS cord-006856-b1w25ob5 757 27 ) ) -RRB- cord-006856-b1w25ob5 757 28 . . . cord-006856-b1w25ob5 758 1 Mean mean JJ cord-006856-b1w25ob5 758 2 donor donor NN cord-006856-b1w25ob5 758 3 age age NN cord-006856-b1w25ob5 758 4 was be VBD cord-006856-b1w25ob5 758 5 45 45 CD cord-006856-b1w25ob5 758 6 years year NNS cord-006856-b1w25ob5 758 7 ( ( -LRB- cord-006856-b1w25ob5 758 8 range range NN cord-006856-b1w25ob5 758 9 , , , cord-006856-b1w25ob5 758 10 21 21 CD cord-006856-b1w25ob5 758 11 - - SYM cord-006856-b1w25ob5 758 12 70 70 CD cord-006856-b1w25ob5 758 13 ) ) -RRB- cord-006856-b1w25ob5 759 1 ; ; : cord-006856-b1w25ob5 759 2 mean mean VB cord-006856-b1w25ob5 759 3 recipient recipient NN cord-006856-b1w25ob5 759 4 age age NN cord-006856-b1w25ob5 759 5 was be VBD cord-006856-b1w25ob5 759 6 40 40 CD cord-006856-b1w25ob5 760 1 ( ( -LRB- cord-006856-b1w25ob5 760 2 range range NN cord-006856-b1w25ob5 760 3 , , , cord-006856-b1w25ob5 760 4 2 2 CD cord-006856-b1w25ob5 760 5 - - SYM cord-006856-b1w25ob5 760 6 72 72 CD cord-006856-b1w25ob5 760 7 ) ) -RRB- cord-006856-b1w25ob5 760 8 years year NNS cord-006856-b1w25ob5 760 9 . . . cord-006856-b1w25ob5 761 1 In in IN cord-006856-b1w25ob5 761 2 group group NN cord-006856-b1w25ob5 761 3 1 1 CD cord-006856-b1w25ob5 761 4 only only RB cord-006856-b1w25ob5 761 5 2 2 CD cord-006856-b1w25ob5 761 6 transplants transplant NNS cord-006856-b1w25ob5 761 7 were be VBD cord-006856-b1w25ob5 761 8 emotionally emotionally RB cord-006856-b1w25ob5 761 9 related relate VBN cord-006856-b1w25ob5 761 10 ( ( -LRB- cord-006856-b1w25ob5 761 11 5 5 CD cord-006856-b1w25ob5 761 12 % % NN cord-006856-b1w25ob5 761 13 ) ) -RRB- cord-006856-b1w25ob5 761 14 , , , cord-006856-b1w25ob5 761 15 whereas whereas IN cord-006856-b1w25ob5 761 16 in in IN cord-006856-b1w25ob5 761 17 group group NN cord-006856-b1w25ob5 761 18 2 2 CD cord-006856-b1w25ob5 761 19 the the DT cord-006856-b1w25ob5 761 20 proportion proportion NN cord-006856-b1w25ob5 761 21 increased increase VBD cord-006856-b1w25ob5 761 22 to to IN cord-006856-b1w25ob5 761 23 25 25 CD cord-006856-b1w25ob5 761 24 % % NN cord-006856-b1w25ob5 761 25 . . . cord-006856-b1w25ob5 762 1 Graft graft NN cord-006856-b1w25ob5 762 2 survival survival NN cord-006856-b1w25ob5 762 3 of of IN cord-006856-b1w25ob5 762 4 living live VBG cord-006856-b1w25ob5 762 5 donated donate VBN cord-006856-b1w25ob5 762 6 kidneys kidney NNS cord-006856-b1w25ob5 762 7 was be VBD cord-006856-b1w25ob5 762 8 better well JJR cord-006856-b1w25ob5 762 9 when when WRB cord-006856-b1w25ob5 762 10 compared compare VBN cord-006856-b1w25ob5 762 11 with with IN cord-006856-b1w25ob5 762 12 cadaveric cadaveric JJ cord-006856-b1w25ob5 762 13 kidneys kidney NNS cord-006856-b1w25ob5 762 14 ( ( -LRB- cord-006856-b1w25ob5 762 15 95 95 CD cord-006856-b1w25ob5 762 16 % % NN cord-006856-b1w25ob5 762 17 versus versus IN cord-006856-b1w25ob5 762 18 92 92 CD cord-006856-b1w25ob5 762 19 % % NN cord-006856-b1w25ob5 762 20 at at IN cord-006856-b1w25ob5 762 21 one one CD cord-006856-b1w25ob5 762 22 and and CC cord-006856-b1w25ob5 762 23 89 89 CD cord-006856-b1w25ob5 762 24 % % NN cord-006856-b1w25ob5 762 25 and and CC cord-006856-b1w25ob5 762 26 83 83 CD cord-006856-b1w25ob5 762 27 % % NN cord-006856-b1w25ob5 762 28 at at IN cord-006856-b1w25ob5 762 29 five five CD cord-006856-b1w25ob5 762 30 years year NNS cord-006856-b1w25ob5 762 31 ) ) -RRB- cord-006856-b1w25ob5 762 32 , , , cord-006856-b1w25ob5 762 33 but but CC cord-006856-b1w25ob5 762 34 the the DT cord-006856-b1w25ob5 762 35 difference difference NN cord-006856-b1w25ob5 762 36 did do VBD cord-006856-b1w25ob5 762 37 not not RB cord-006856-b1w25ob5 762 38 reach reach VB cord-006856-b1w25ob5 762 39 statistical statistical JJ cord-006856-b1w25ob5 762 40 significance significance NN cord-006856-b1w25ob5 762 41 ( ( -LRB- cord-006856-b1w25ob5 762 42 P p NN cord-006856-b1w25ob5 762 43 = = SYM cord-006856-b1w25ob5 762 44 0.06 0.06 CD cord-006856-b1w25ob5 762 45 ) ) -RRB- cord-006856-b1w25ob5 762 46 . . . cord-006856-b1w25ob5 763 1 LRTs LRTs NNP cord-006856-b1w25ob5 763 2 and and CC cord-006856-b1w25ob5 763 3 ERTs ert NNS cord-006856-b1w25ob5 763 4 produced produce VBD cord-006856-b1w25ob5 763 5 equal equal JJ cord-006856-b1w25ob5 763 6 outcome outcome NN cord-006856-b1w25ob5 763 7 . . . cord-006856-b1w25ob5 764 1 Overall overall JJ cord-006856-b1w25ob5 764 2 graft graft NN cord-006856-b1w25ob5 764 3 loss loss NN cord-006856-b1w25ob5 764 4 rate rate NN cord-006856-b1w25ob5 764 5 after after IN cord-006856-b1w25ob5 764 6 a a DT cord-006856-b1w25ob5 764 7 median median JJ cord-006856-b1w25ob5 764 8 follow follow NN cord-006856-b1w25ob5 764 9 - - HYPH cord-006856-b1w25ob5 764 10 up up NN cord-006856-b1w25ob5 764 11 of of IN cord-006856-b1w25ob5 764 12 six six CD cord-006856-b1w25ob5 764 13 ( ( -LRB- cord-006856-b1w25ob5 764 14 range range NN cord-006856-b1w25ob5 764 15 , , , cord-006856-b1w25ob5 764 16 0.5 0.5 CD cord-006856-b1w25ob5 764 17 - - HYPH cord-006856-b1w25ob5 764 18 11.5 11.5 CD cord-006856-b1w25ob5 764 19 ) ) -RRB- cord-006856-b1w25ob5 764 20 years year NNS cord-006856-b1w25ob5 764 21 was be VBD cord-006856-b1w25ob5 764 22 11 11 CD cord-006856-b1w25ob5 764 23 % % NN cord-006856-b1w25ob5 764 24 ( ( -LRB- cord-006856-b1w25ob5 764 25 LRTs lrts NN cord-006856-b1w25ob5 764 26 ) ) -RRB- cord-006856-b1w25ob5 764 27 vs. vs. IN cord-006856-b1w25ob5 764 28 16 16 CD cord-006856-b1w25ob5 764 29 % % NN cord-006856-b1w25ob5 764 30 ( ( -LRB- cord-006856-b1w25ob5 764 31 ERTs ert NNS cord-006856-b1w25ob5 764 32 ) ) -RRB- cord-006856-b1w25ob5 764 33 . . . cord-006856-b1w25ob5 765 1 The the DT cord-006856-b1w25ob5 765 2 rejection rejection NN cord-006856-b1w25ob5 765 3 rate rate NN cord-006856-b1w25ob5 765 4 was be VBD cord-006856-b1w25ob5 765 5 slightly slightly RB cord-006856-b1w25ob5 765 6 higher high JJR cord-006856-b1w25ob5 765 7 in in IN cord-006856-b1w25ob5 765 8 the the DT cord-006856-b1w25ob5 765 9 LRT LRT NNP cord-006856-b1w25ob5 765 10 group group NN cord-006856-b1w25ob5 765 11 with with IN cord-006856-b1w25ob5 765 12 31 31 CD cord-006856-b1w25ob5 765 13 % % NN cord-006856-b1w25ob5 765 14 vs. vs. IN cord-006856-b1w25ob5 765 15 22 22 CD cord-006856-b1w25ob5 765 16 % % NN cord-006856-b1w25ob5 765 17 ( ( -LRB- cord-006856-b1w25ob5 765 18 P p NN cord-006856-b1w25ob5 765 19 > > XX cord-006856-b1w25ob5 765 20 0.05 0.05 CD cord-006856-b1w25ob5 765 21 , , , cord-006856-b1w25ob5 765 22 n.s n.s NNP cord-006856-b1w25ob5 765 23 . . NNP cord-006856-b1w25ob5 765 24 ) ) -RRB- cord-006856-b1w25ob5 765 25 . . . cord-006856-b1w25ob5 766 1 Ten ten CD cord-006856-b1w25ob5 766 2 living live VBG cord-006856-b1w25ob5 766 3 donated donate VBN cord-006856-b1w25ob5 766 4 grafts graft NNS cord-006856-b1w25ob5 766 5 were be VBD cord-006856-b1w25ob5 766 6 lost lose VBN cord-006856-b1w25ob5 766 7 and and CC cord-006856-b1w25ob5 766 8 seven seven CD cord-006856-b1w25ob5 766 9 recipients recipient NNS cord-006856-b1w25ob5 766 10 of of IN cord-006856-b1w25ob5 766 11 a a DT cord-006856-b1w25ob5 766 12 living living NN cord-006856-b1w25ob5 766 13 donated donate VBN cord-006856-b1w25ob5 766 14 graft graft NN cord-006856-b1w25ob5 766 15 died die VBD cord-006856-b1w25ob5 766 16 . . . cord-006856-b1w25ob5 767 1 Causes cause NNS cord-006856-b1w25ob5 767 2 of of IN cord-006856-b1w25ob5 767 3 death death NN cord-006856-b1w25ob5 767 4 were be VBD cord-006856-b1w25ob5 767 5 cardiac cardiac JJ cord-006856-b1w25ob5 767 6 ischemia ischemia NN cord-006856-b1w25ob5 767 7 ( ( -LRB- cord-006856-b1w25ob5 767 8 n n NN cord-006856-b1w25ob5 767 9 = = SYM cord-006856-b1w25ob5 767 10 1 1 CD cord-006856-b1w25ob5 767 11 ) ) -RRB- cord-006856-b1w25ob5 767 12 , , , cord-006856-b1w25ob5 767 13 pulmonary pulmonary JJ cord-006856-b1w25ob5 767 14 embolism embolism NN cord-006856-b1w25ob5 767 15 ( ( -LRB- cord-006856-b1w25ob5 767 16 n n NN cord-006856-b1w25ob5 767 17 = = SYM cord-006856-b1w25ob5 767 18 1 1 CD cord-006856-b1w25ob5 767 19 ) ) -RRB- cord-006856-b1w25ob5 767 20 , , , cord-006856-b1w25ob5 767 21 fungal fungal JJ cord-006856-b1w25ob5 767 22 infections infection NNS cord-006856-b1w25ob5 767 23 ( ( -LRB- cord-006856-b1w25ob5 767 24 n n NN cord-006856-b1w25ob5 767 25 = = SYM cord-006856-b1w25ob5 767 26 1 1 CD cord-006856-b1w25ob5 767 27 ) ) -RRB- cord-006856-b1w25ob5 767 28 , , , cord-006856-b1w25ob5 767 29 suicide suicide NN cord-006856-b1w25ob5 767 30 ( ( -LRB- cord-006856-b1w25ob5 767 31 n n NN cord-006856-b1w25ob5 767 32 = = SYM cord-006856-b1w25ob5 767 33 1 1 CD cord-006856-b1w25ob5 767 34 ) ) -RRB- cord-006856-b1w25ob5 767 35 , , , cord-006856-b1w25ob5 767 36 and and CC cord-006856-b1w25ob5 767 37 3 3 CD cord-006856-b1w25ob5 767 38 causes cause NNS cord-006856-b1w25ob5 767 39 were be VBD cord-006856-b1w25ob5 767 40 not not RB cord-006856-b1w25ob5 767 41 specified specify VBN cord-006856-b1w25ob5 767 42 . . . cord-006856-b1w25ob5 768 1 Conclusions conclusion NNS cord-006856-b1w25ob5 768 2 . . . cord-006856-b1w25ob5 769 1 The the DT cord-006856-b1w25ob5 769 2 frequency frequency NN cord-006856-b1w25ob5 769 3 of of IN cord-006856-b1w25ob5 769 4 living living NN cord-006856-b1w25ob5 769 5 - - HYPH cord-006856-b1w25ob5 769 6 related relate VBN cord-006856-b1w25ob5 769 7 and and CC cord-006856-b1w25ob5 769 8 unrelated unrelated JJ cord-006856-b1w25ob5 769 9 kidney kidney NN cord-006856-b1w25ob5 769 10 donation donation NN cord-006856-b1w25ob5 769 11 has have VBZ cord-006856-b1w25ob5 769 12 increased increase VBN cord-006856-b1w25ob5 769 13 during during IN cord-006856-b1w25ob5 769 14 the the DT cord-006856-b1w25ob5 769 15 past past JJ cord-006856-b1w25ob5 769 16 two two CD cord-006856-b1w25ob5 769 17 decades decade NNS cord-006856-b1w25ob5 769 18 at at IN cord-006856-b1w25ob5 769 19 our -PRON- PRP$ cord-006856-b1w25ob5 769 20 institution institution NN cord-006856-b1w25ob5 769 21 . . . cord-006856-b1w25ob5 770 1 Equal equal JJ cord-006856-b1w25ob5 770 2 results result NNS cord-006856-b1w25ob5 770 3 for for IN cord-006856-b1w25ob5 770 4 cadaveric cadaveric JJ cord-006856-b1w25ob5 770 5 grafts graft NNS cord-006856-b1w25ob5 770 6 were be VBD cord-006856-b1w25ob5 770 7 achieved achieve VBN cord-006856-b1w25ob5 770 8 when when WRB cord-006856-b1w25ob5 770 9 compared compare VBN cord-006856-b1w25ob5 770 10 to to IN cord-006856-b1w25ob5 770 11 LRT LRT NNP cord-006856-b1w25ob5 770 12 and and CC cord-006856-b1w25ob5 770 13 ERL ERL NNP cord-006856-b1w25ob5 770 14 . . . cord-006856-b1w25ob5 771 1 Background background NN cord-006856-b1w25ob5 771 2 . . . cord-006856-b1w25ob5 772 1 The the DT cord-006856-b1w25ob5 772 2 20S 20s CD cord-006856-b1w25ob5 772 3 proteasome proteasome NN cord-006856-b1w25ob5 772 4 plays play VBZ cord-006856-b1w25ob5 772 5 an an DT cord-006856-b1w25ob5 772 6 important important JJ cord-006856-b1w25ob5 772 7 role role NN cord-006856-b1w25ob5 772 8 in in IN cord-006856-b1w25ob5 772 9 the the DT cord-006856-b1w25ob5 772 10 nonlysosomal nonlysosomal JJ cord-006856-b1w25ob5 772 11 pathway pathway NN cord-006856-b1w25ob5 772 12 of of IN cord-006856-b1w25ob5 772 13 intracellular intracellular JJ cord-006856-b1w25ob5 772 14 protein protein NN cord-006856-b1w25ob5 772 15 degradation degradation NN cord-006856-b1w25ob5 772 16 and and CC cord-006856-b1w25ob5 772 17 apoptosis apoptosis NN cord-006856-b1w25ob5 772 18 , , , cord-006856-b1w25ob5 772 19 thus thus RB cord-006856-b1w25ob5 772 20 being be VBG cord-006856-b1w25ob5 772 21 a a DT cord-006856-b1w25ob5 772 22 possible possible JJ cord-006856-b1w25ob5 772 23 marker marker NN cord-006856-b1w25ob5 772 24 for for IN cord-006856-b1w25ob5 772 25 ischemic ischemic JJ cord-006856-b1w25ob5 772 26 and and CC cord-006856-b1w25ob5 772 27 reperfusion reperfusion NN cord-006856-b1w25ob5 772 28 injuries injury NNS cord-006856-b1w25ob5 772 29 . . . cord-006856-b1w25ob5 773 1 The the DT cord-006856-b1w25ob5 773 2 aim aim NN cord-006856-b1w25ob5 773 3 of of IN cord-006856-b1w25ob5 773 4 this this DT cord-006856-b1w25ob5 773 5 study study NN cord-006856-b1w25ob5 773 6 was be VBD cord-006856-b1w25ob5 773 7 to to TO cord-006856-b1w25ob5 773 8 monitor monitor VB cord-006856-b1w25ob5 773 9 the the DT cord-006856-b1w25ob5 773 10 proteasome proteasome NN cord-006856-b1w25ob5 773 11 levels level NNS cord-006856-b1w25ob5 773 12 in in IN cord-006856-b1w25ob5 773 13 patients patient NNS cord-006856-b1w25ob5 773 14 receiving receive VBG cord-006856-b1w25ob5 773 15 kidney kidney NN cord-006856-b1w25ob5 773 16 transplants transplant NNS cord-006856-b1w25ob5 773 17 to to TO cord-006856-b1w25ob5 773 18 detect detect VB cord-006856-b1w25ob5 773 19 a a DT cord-006856-b1w25ob5 773 20 relationship relationship NN cord-006856-b1w25ob5 773 21 with with IN cord-006856-b1w25ob5 773 22 the the DT cord-006856-b1w25ob5 773 23 return return NN cord-006856-b1w25ob5 773 24 of of IN cord-006856-b1w25ob5 773 25 renal renal JJ cord-006856-b1w25ob5 773 26 function function NN cord-006856-b1w25ob5 773 27 . . . cord-006856-b1w25ob5 774 1 Methods method NNS cord-006856-b1w25ob5 774 2 . . . cord-006856-b1w25ob5 775 1 We -PRON- PRP cord-006856-b1w25ob5 775 2 examined examine VBD cord-006856-b1w25ob5 775 3 12 12 CD cord-006856-b1w25ob5 775 4 patients patient NNS cord-006856-b1w25ob5 775 5 with with IN cord-006856-b1w25ob5 775 6 end end NN cord-006856-b1w25ob5 775 7 stage stage NN cord-006856-b1w25ob5 775 8 renal renal JJ cord-006856-b1w25ob5 775 9 disease disease NN cord-006856-b1w25ob5 775 10 , , , cord-006856-b1w25ob5 775 11 receiving receive VBG cord-006856-b1w25ob5 775 12 kidney kidney NN cord-006856-b1w25ob5 775 13 transplants transplant NNS cord-006856-b1w25ob5 775 14 : : : cord-006856-b1w25ob5 775 15 Blood blood NN cord-006856-b1w25ob5 775 16 samples sample NNS cord-006856-b1w25ob5 775 17 were be VBD cord-006856-b1w25ob5 775 18 collected collect VBN cord-006856-b1w25ob5 775 19 intraoperatively intraoperatively RB cord-006856-b1w25ob5 775 20 and and CC cord-006856-b1w25ob5 775 21 postoperatively postoperatively RB cord-006856-b1w25ob5 775 22 on on IN cord-006856-b1w25ob5 775 23 5 5 CD cord-006856-b1w25ob5 775 24 consecutive consecutive JJ cord-006856-b1w25ob5 775 25 days day NNS cord-006856-b1w25ob5 775 26 and and CC cord-006856-b1w25ob5 775 27 20S 20s NN cord-006856-b1w25ob5 775 28 proteasome proteasome NN cord-006856-b1w25ob5 775 29 levels level NNS cord-006856-b1w25ob5 775 30 were be VBD cord-006856-b1w25ob5 775 31 measured measure VBN cord-006856-b1w25ob5 775 32 for for IN cord-006856-b1w25ob5 775 33 each each DT cord-006856-b1w25ob5 775 34 sample sample NN cord-006856-b1w25ob5 775 35 with with IN cord-006856-b1w25ob5 775 36 a a DT cord-006856-b1w25ob5 775 37 sandwich sandwich NN cord-006856-b1w25ob5 775 38 ELISA ELISA NNP cord-006856-b1w25ob5 775 39 as as IN cord-006856-b1w25ob5 775 40 described describe VBN cord-006856-b1w25ob5 775 41 by by IN cord-006856-b1w25ob5 775 42 Dutaud Dutaud NNP cord-006856-b1w25ob5 775 43 et et NNP cord-006856-b1w25ob5 775 44 al al NNP cord-006856-b1w25ob5 775 45 . . . cord-006856-b1w25ob5 776 1 Anesthesia anesthesia NN cord-006856-b1w25ob5 776 2 and and CC cord-006856-b1w25ob5 776 3 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 776 4 medications medication NNS cord-006856-b1w25ob5 776 5 were be VBD cord-006856-b1w25ob5 776 6 standardized standardize VBN cord-006856-b1w25ob5 776 7 , , , cord-006856-b1w25ob5 776 8 creatinine creatinine NN cord-006856-b1w25ob5 776 9 clearance clearance NN cord-006856-b1w25ob5 776 10 and and CC cord-006856-b1w25ob5 776 11 urine urine NN cord-006856-b1w25ob5 776 12 output output NN cord-006856-b1w25ob5 776 13 were be VBD cord-006856-b1w25ob5 776 14 assessed assess VBN cord-006856-b1w25ob5 776 15 daily daily RB cord-006856-b1w25ob5 776 16 on on IN cord-006856-b1w25ob5 776 17 a a DT cord-006856-b1w25ob5 776 18 routine routine JJ cord-006856-b1w25ob5 776 19 basis basis NN cord-006856-b1w25ob5 776 20 . . . cord-006856-b1w25ob5 777 1 Results result NNS cord-006856-b1w25ob5 777 2 . . . cord-006856-b1w25ob5 778 1 Patients patient NNS cord-006856-b1w25ob5 778 2 who who WP cord-006856-b1w25ob5 778 3 had have VBD cord-006856-b1w25ob5 778 4 no no DT cord-006856-b1w25ob5 778 5 adequate adequate JJ cord-006856-b1w25ob5 778 6 urine urine NN cord-006856-b1w25ob5 778 7 output output NN cord-006856-b1w25ob5 778 8 ( ( -LRB- cord-006856-b1w25ob5 778 9 430 430 CD cord-006856-b1w25ob5 778 10 ± ± CD cord-006856-b1w25ob5 778 11 300 300 CD cord-006856-b1w25ob5 778 12 ml ml NNS cord-006856-b1w25ob5 778 13 ) ) -RRB- cord-006856-b1w25ob5 778 14 after after IN cord-006856-b1w25ob5 778 15 the the DT cord-006856-b1w25ob5 778 16 4th 4th JJ cord-006856-b1w25ob5 778 17 postoperative postoperative JJ cord-006856-b1w25ob5 778 18 day day NN cord-006856-b1w25ob5 778 19 had have VBD cord-006856-b1w25ob5 778 20 significantly significantly RB cord-006856-b1w25ob5 778 21 higher high JJR cord-006856-b1w25ob5 778 22 proteasome proteasome NN cord-006856-b1w25ob5 778 23 levels level NNS cord-006856-b1w25ob5 778 24 intraoperatively intraoperatively RB cord-006856-b1w25ob5 778 25 than than IN cord-006856-b1w25ob5 778 26 patients patient NNS cord-006856-b1w25ob5 778 27 with with IN cord-006856-b1w25ob5 778 28 high high JJ cord-006856-b1w25ob5 778 29 urine urine NN cord-006856-b1w25ob5 778 30 output output NN cord-006856-b1w25ob5 778 31 ( ( -LRB- cord-006856-b1w25ob5 778 32 4032 4032 CD cord-006856-b1w25ob5 778 33 ± ± CD cord-006856-b1w25ob5 778 34 1076 1076 CD cord-006856-b1w25ob5 778 35 ml ml NNS cord-006856-b1w25ob5 778 36 ; ; : cord-006856-b1w25ob5 778 37 1.7 1.7 CD cord-006856-b1w25ob5 778 38 ± ± CD cord-006856-b1w25ob5 778 39 1.5 1.5 CD cord-006856-b1w25ob5 778 40 µg µg NN cord-006856-b1w25ob5 778 41 / / SYM cord-006856-b1w25ob5 778 42 ml ml NN cord-006856-b1w25ob5 778 43 low low JJ cord-006856-b1w25ob5 778 44 vs. vs. FW cord-006856-b1w25ob5 778 45 0.5 0.5 CD cord-006856-b1w25ob5 778 46 ± ± CD cord-006856-b1w25ob5 779 1 0.4 0.4 CD cord-006856-b1w25ob5 779 2 µg µg NN cord-006856-b1w25ob5 779 3 / / SYM cord-006856-b1w25ob5 779 4 ml ml CC cord-006856-b1w25ob5 779 5 high high JJ cord-006856-b1w25ob5 779 6 urine urine NN cord-006856-b1w25ob5 779 7 output output NN cord-006856-b1w25ob5 779 8 , , , cord-006856-b1w25ob5 779 9 means mean VBZ cord-006856-b1w25ob5 779 10 with with IN cord-006856-b1w25ob5 779 11 standard standard JJ cord-006856-b1w25ob5 779 12 deviations deviation NNS cord-006856-b1w25ob5 779 13 , , , cord-006856-b1w25ob5 779 14 P p NN cord-006856-b1w25ob5 779 15 = = SYM cord-006856-b1w25ob5 779 16 0.02 0.02 CD cord-006856-b1w25ob5 779 17 ) ) -RRB- cord-006856-b1w25ob5 779 18 . . . cord-006856-b1w25ob5 780 1 This this DT cord-006856-b1w25ob5 780 2 difference difference NN cord-006856-b1w25ob5 780 3 in in IN cord-006856-b1w25ob5 780 4 proteasome proteasome NN cord-006856-b1w25ob5 780 5 levels level NNS cord-006856-b1w25ob5 780 6 seemed seem VBD cord-006856-b1w25ob5 780 7 to to TO cord-006856-b1w25ob5 780 8 even even RB cord-006856-b1w25ob5 780 9 out out RP cord-006856-b1w25ob5 780 10 during during IN cord-006856-b1w25ob5 780 11 the the DT cord-006856-b1w25ob5 780 12 follow follow NN cord-006856-b1w25ob5 780 13 - - HYPH cord-006856-b1w25ob5 780 14 up up NN cord-006856-b1w25ob5 780 15 period period NN cord-006856-b1w25ob5 780 16 . . . cord-006856-b1w25ob5 781 1 Conclusions conclusion NNS cord-006856-b1w25ob5 781 2 . . . cord-006856-b1w25ob5 782 1 Patients patient NNS cord-006856-b1w25ob5 782 2 with with IN cord-006856-b1w25ob5 782 3 impaired impaired JJ cord-006856-b1w25ob5 782 4 renal renal JJ cord-006856-b1w25ob5 782 5 function function NN cord-006856-b1w25ob5 782 6 after after IN cord-006856-b1w25ob5 782 7 kidney kidney NN cord-006856-b1w25ob5 782 8 transplant transplant NN cord-006856-b1w25ob5 782 9 had have VBD cord-006856-b1w25ob5 782 10 significantly significantly RB cord-006856-b1w25ob5 782 11 higher high JJR cord-006856-b1w25ob5 782 12 proteasome proteasome NN cord-006856-b1w25ob5 782 13 levels level NNS cord-006856-b1w25ob5 782 14 intraoperatively intraoperatively RB cord-006856-b1w25ob5 782 15 . . . cord-006856-b1w25ob5 783 1 A a DT cord-006856-b1w25ob5 783 2 higher high JJR cord-006856-b1w25ob5 783 3 plasma plasma NN cord-006856-b1w25ob5 783 4 level level NN cord-006856-b1w25ob5 783 5 of of IN cord-006856-b1w25ob5 783 6 proteasomes proteasomes NNP cord-006856-b1w25ob5 783 7 intraoperatively intraoperatively NNP cord-006856-b1w25ob5 783 8 may may MD cord-006856-b1w25ob5 783 9 therefore therefore RB cord-006856-b1w25ob5 783 10 be be VB cord-006856-b1w25ob5 783 11 a a DT cord-006856-b1w25ob5 783 12 negative negative JJ cord-006856-b1w25ob5 783 13 prognostic prognostic JJ cord-006856-b1w25ob5 783 14 marker marker NN cord-006856-b1w25ob5 783 15 for for IN cord-006856-b1w25ob5 783 16 postoperative postoperative JJ cord-006856-b1w25ob5 783 17 return return NN cord-006856-b1w25ob5 783 18 of of IN cord-006856-b1w25ob5 783 19 renal renal JJ cord-006856-b1w25ob5 783 20 function function NN cord-006856-b1w25ob5 783 21 of of IN cord-006856-b1w25ob5 783 22 the the DT cord-006856-b1w25ob5 783 23 transplanted transplant VBN cord-006856-b1w25ob5 783 24 kidney kidney NN cord-006856-b1w25ob5 783 25 . . . cord-006856-b1w25ob5 784 1 Background background NN cord-006856-b1w25ob5 784 2 . . . cord-006856-b1w25ob5 785 1 Dendritic dendritic JJ cord-006856-b1w25ob5 785 2 cells cell NNS cord-006856-b1w25ob5 785 3 ( ( -LRB- cord-006856-b1w25ob5 785 4 DCs DCs NNP cord-006856-b1w25ob5 785 5 ) ) -RRB- cord-006856-b1w25ob5 785 6 are be VBP cord-006856-b1w25ob5 785 7 the the DT cord-006856-b1w25ob5 785 8 most most RBS cord-006856-b1w25ob5 785 9 potent potent JJ cord-006856-b1w25ob5 785 10 antigen antigen NN cord-006856-b1w25ob5 785 11 - - HYPH cord-006856-b1w25ob5 785 12 presenting present VBG cord-006856-b1w25ob5 785 13 cells cell NNS cord-006856-b1w25ob5 785 14 and and CC cord-006856-b1w25ob5 785 15 are be VBP cord-006856-b1w25ob5 785 16 pivotal pivotal JJ cord-006856-b1w25ob5 785 17 for for IN cord-006856-b1w25ob5 785 18 initiating initiate VBG cord-006856-b1w25ob5 785 19 allograft allograft NN cord-006856-b1w25ob5 785 20 immunity immunity NN cord-006856-b1w25ob5 785 21 . . . cord-006856-b1w25ob5 786 1 Recently recently RB cord-006856-b1w25ob5 786 2 , , , cord-006856-b1w25ob5 786 3 however however RB cord-006856-b1w25ob5 786 4 , , , cord-006856-b1w25ob5 786 5 particular particular JJ cord-006856-b1w25ob5 786 6 DC DC NNP cord-006856-b1w25ob5 786 7 subsets subset NNS cord-006856-b1w25ob5 786 8 have have VBP cord-006856-b1w25ob5 786 9 also also RB cord-006856-b1w25ob5 786 10 been be VBN cord-006856-b1w25ob5 786 11 implicated implicate VBN cord-006856-b1w25ob5 786 12 in in IN cord-006856-b1w25ob5 786 13 allogeneic allogeneic NN cord-006856-b1w25ob5 786 14 tolerance tolerance NN cord-006856-b1w25ob5 786 15 induction induction NN cord-006856-b1w25ob5 786 16 . . . cord-006856-b1w25ob5 787 1 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 788 1 ( ( -LRB- cord-006856-b1w25ob5 788 2 Alemtuzumab Alemtuzumab NNP cord-006856-b1w25ob5 788 3 ) ) -RRB- cord-006856-b1w25ob5 788 4 is be VBZ cord-006856-b1w25ob5 788 5 a a DT cord-006856-b1w25ob5 788 6 novel novel JJ cord-006856-b1w25ob5 788 7 T t NN cord-006856-b1w25ob5 788 8 - - HYPH cord-006856-b1w25ob5 788 9 cell cell NN cord-006856-b1w25ob5 788 10 - - HYPH cord-006856-b1w25ob5 788 11 depleting deplete VBG cord-006856-b1w25ob5 788 12 antibody antibody NN cord-006856-b1w25ob5 788 13 that that WDT cord-006856-b1w25ob5 788 14 is be VBZ cord-006856-b1w25ob5 788 15 currently currently RB cord-006856-b1w25ob5 788 16 under under IN cord-006856-b1w25ob5 788 17 investigation investigation NN cord-006856-b1w25ob5 788 18 for for IN cord-006856-b1w25ob5 788 19 the the DT cord-006856-b1w25ob5 788 20 use use NN cord-006856-b1w25ob5 788 21 in in IN cord-006856-b1w25ob5 788 22 allogeneic allogeneic NN cord-006856-b1w25ob5 788 23 organ organ NN cord-006856-b1w25ob5 788 24 transplantation transplantation NN cord-006856-b1w25ob5 788 25 and and CC cord-006856-b1w25ob5 788 26 may may MD cord-006856-b1w25ob5 788 27 confer confer VB cord-006856-b1w25ob5 788 28 tolerogenic tolerogenic JJ cord-006856-b1w25ob5 788 29 properties property NNS cord-006856-b1w25ob5 788 30 . . . cord-006856-b1w25ob5 789 1 Here here RB cord-006856-b1w25ob5 789 2 we -PRON- PRP cord-006856-b1w25ob5 789 3 study study VBP cord-006856-b1w25ob5 789 4 the the DT cord-006856-b1w25ob5 789 5 effect effect NN cord-006856-b1w25ob5 789 6 of of IN cord-006856-b1w25ob5 789 7 Alemtuzumab Alemtuzumab NNP cord-006856-b1w25ob5 789 8 on on IN cord-006856-b1w25ob5 789 9 peripheral peripheral JJ cord-006856-b1w25ob5 789 10 DC DC NNP cord-006856-b1w25ob5 789 11 subsets subset NNS cord-006856-b1w25ob5 789 12 in in IN cord-006856-b1w25ob5 789 13 kidney kidney NN cord-006856-b1w25ob5 789 14 transplant transplant NN cord-006856-b1w25ob5 789 15 patients patient NNS cord-006856-b1w25ob5 789 16 under under IN cord-006856-b1w25ob5 789 17 FK506 fk506 JJ cord-006856-b1w25ob5 789 18 monotherapy monotherapy NN cord-006856-b1w25ob5 789 19 in in IN cord-006856-b1w25ob5 789 20 comparison comparison NN cord-006856-b1w25ob5 789 21 to to IN cord-006856-b1w25ob5 789 22 patients patient NNS cord-006856-b1w25ob5 789 23 under under IN cord-006856-b1w25ob5 789 24 conventional conventional JJ cord-006856-b1w25ob5 789 25 triple triple JJ cord-006856-b1w25ob5 789 26 therapy therapy NN cord-006856-b1w25ob5 789 27 . . . cord-006856-b1w25ob5 790 1 Methods method NNS cord-006856-b1w25ob5 790 2 . . . cord-006856-b1w25ob5 791 1 Patients patient NNS cord-006856-b1w25ob5 791 2 receiving receive VBG cord-006856-b1w25ob5 791 3 their -PRON- PRP$ cord-006856-b1w25ob5 791 4 first first JJ cord-006856-b1w25ob5 791 5 renal renal JJ cord-006856-b1w25ob5 791 6 allograft allograft NN cord-006856-b1w25ob5 791 7 were be VBD cord-006856-b1w25ob5 791 8 recruited recruit VBN cord-006856-b1w25ob5 791 9 within within IN cord-006856-b1w25ob5 791 10 the the DT cord-006856-b1w25ob5 791 11 TaCAM TaCAM NNP cord-006856-b1w25ob5 791 12 trial trial NN cord-006856-b1w25ob5 791 13 and and CC cord-006856-b1w25ob5 791 14 randomly randomly RB cord-006856-b1w25ob5 791 15 assigned assign VBN cord-006856-b1w25ob5 791 16 to to TO cord-006856-b1w25ob5 791 17 receive receive VB cord-006856-b1w25ob5 791 18 either either CC cord-006856-b1w25ob5 791 19 Alemtuzumab Alemtuzumab NNP cord-006856-b1w25ob5 791 20 as as IN cord-006856-b1w25ob5 791 21 induction induction NN cord-006856-b1w25ob5 791 22 agent agent NN cord-006856-b1w25ob5 791 23 followed follow VBN cord-006856-b1w25ob5 791 24 by by IN cord-006856-b1w25ob5 791 25 FK506 FK506 NNP cord-006856-b1w25ob5 791 26 monotherapy monotherapy NN cord-006856-b1w25ob5 791 27 ( ( -LRB- cord-006856-b1w25ob5 791 28 n n NN cord-006856-b1w25ob5 791 29 = = SYM cord-006856-b1w25ob5 791 30 7 7 CD cord-006856-b1w25ob5 791 31 ) ) -RRB- cord-006856-b1w25ob5 791 32 or or CC cord-006856-b1w25ob5 791 33 to to TO cord-006856-b1w25ob5 791 34 receive receive VB cord-006856-b1w25ob5 791 35 conventional conventional JJ cord-006856-b1w25ob5 791 36 immunosupression immunosupression NN cord-006856-b1w25ob5 791 37 consisting consist VBG cord-006856-b1w25ob5 791 38 of of IN cord-006856-b1w25ob5 791 39 FK506 FK506 NNP cord-006856-b1w25ob5 791 40 , , , cord-006856-b1w25ob5 791 41 mycophenolate mycophenolate NNP cord-006856-b1w25ob5 791 42 mofetil mofetil NNP cord-006856-b1w25ob5 791 43 and and CC cord-006856-b1w25ob5 791 44 steroids steroids NNP cord-006856-b1w25ob5 791 45 ( ( -LRB- cord-006856-b1w25ob5 791 46 n n NN cord-006856-b1w25ob5 791 47 = = SYM cord-006856-b1w25ob5 791 48 7 7 CD cord-006856-b1w25ob5 791 49 ) ) -RRB- cord-006856-b1w25ob5 791 50 . . . cord-006856-b1w25ob5 792 1 Absolute absolute JJ cord-006856-b1w25ob5 792 2 numbers number NNS cord-006856-b1w25ob5 792 3 of of IN cord-006856-b1w25ob5 792 4 peripheral peripheral JJ cord-006856-b1w25ob5 792 5 blood blood NN cord-006856-b1w25ob5 792 6 DCs dc NNS cord-006856-b1w25ob5 792 7 and and CC cord-006856-b1w25ob5 792 8 their -PRON- PRP$ cord-006856-b1w25ob5 792 9 different different JJ cord-006856-b1w25ob5 792 10 subpopulations subpopulation NNS cord-006856-b1w25ob5 792 11 were be VBD cord-006856-b1w25ob5 792 12 assessed assess VBN cord-006856-b1w25ob5 792 13 by by IN cord-006856-b1w25ob5 792 14 four four CD cord-006856-b1w25ob5 792 15 - - HYPH cord-006856-b1w25ob5 792 16 colour colour NN cord-006856-b1w25ob5 792 17 , , , cord-006856-b1w25ob5 792 18 single single JJ cord-006856-b1w25ob5 792 19 - - HYPH cord-006856-b1w25ob5 792 20 platform platform NN cord-006856-b1w25ob5 792 21 fluorocytometry fluorocytometry NN cord-006856-b1w25ob5 792 22 at at IN cord-006856-b1w25ob5 792 23 the the DT cord-006856-b1w25ob5 792 24 day day NN cord-006856-b1w25ob5 792 25 before before RB cord-006856-b1w25ob5 792 26 and and CC cord-006856-b1w25ob5 792 27 1 1 CD cord-006856-b1w25ob5 792 28 , , , cord-006856-b1w25ob5 792 29 4 4 CD cord-006856-b1w25ob5 792 30 , , , cord-006856-b1w25ob5 792 31 12 12 CD cord-006856-b1w25ob5 792 32 , , , cord-006856-b1w25ob5 792 33 and and CC cord-006856-b1w25ob5 792 34 24 24 CD cord-006856-b1w25ob5 792 35 weeks week NNS cord-006856-b1w25ob5 792 36 after after IN cord-006856-b1w25ob5 792 37 the the DT cord-006856-b1w25ob5 792 38 transplant transplant NN cord-006856-b1w25ob5 792 39 procedure procedure NN cord-006856-b1w25ob5 792 40 , , , cord-006856-b1w25ob5 792 41 respectively respectively RB cord-006856-b1w25ob5 792 42 . . . cord-006856-b1w25ob5 793 1 Peripheral peripheral JJ cord-006856-b1w25ob5 793 2 DCs dc NNS cord-006856-b1w25ob5 793 3 were be VBD cord-006856-b1w25ob5 793 4 identified identify VBN cord-006856-b1w25ob5 793 5 as as IN cord-006856-b1w25ob5 793 6 HLA HLA NNP cord-006856-b1w25ob5 793 7 - - HYPH cord-006856-b1w25ob5 793 8 DR DR NNP cord-006856-b1w25ob5 793 9 + + CC cord-006856-b1w25ob5 793 10 and and CC cord-006856-b1w25ob5 793 11 lineage lineage NN cord-006856-b1w25ob5 793 12 - - HYPH cord-006856-b1w25ob5 793 13 negative negative JJ cord-006856-b1w25ob5 793 14 cell cell NN cord-006856-b1w25ob5 793 15 population population NN cord-006856-b1w25ob5 793 16 . . . cord-006856-b1w25ob5 794 1 The the DT cord-006856-b1w25ob5 794 2 respective respective JJ cord-006856-b1w25ob5 794 3 DC DC NNP cord-006856-b1w25ob5 794 4 subpopulations subpopulation NNS cord-006856-b1w25ob5 794 5 were be VBD cord-006856-b1w25ob5 794 6 CD11c CD11c NNP cord-006856-b1w25ob5 794 7 + + SYM cord-006856-b1w25ob5 794 8 DCs DCs NNP cord-006856-b1w25ob5 794 9 ( ( -LRB- cord-006856-b1w25ob5 794 10 myeloid myeloid NNP cord-006856-b1w25ob5 794 11 DCs DCs NNP cord-006856-b1w25ob5 794 12 or or CC cord-006856-b1w25ob5 794 13 DC1 DC1 NNP cord-006856-b1w25ob5 794 14 ) ) -RRB- cord-006856-b1w25ob5 794 15 , , . cord-006856-b1w25ob5 795 1 CD123 CD123 NNP cord-006856-b1w25ob5 795 2 + + CC cord-006856-b1w25ob5 795 3 DCs DCs NNP cord-006856-b1w25ob5 795 4 ( ( -LRB- cord-006856-b1w25ob5 795 5 plasmacytoid plasmacytoid NNP cord-006856-b1w25ob5 795 6 DCs DCs NNP cord-006856-b1w25ob5 795 7 or or CC cord-006856-b1w25ob5 795 8 DC2 DC2 NNP cord-006856-b1w25ob5 795 9 ) ) -RRB- cord-006856-b1w25ob5 795 10 , , , cord-006856-b1w25ob5 795 11 CD11c CD11c NNP cord-006856-b1w25ob5 795 12 + + CC cord-006856-b1w25ob5 795 13 and and CC cord-006856-b1w25ob5 795 14 further far RBR cord-006856-b1w25ob5 795 15 , , , cord-006856-b1w25ob5 795 16 BDCA1 BDCA1 NNP cord-006856-b1w25ob5 796 1 + + CC cord-006856-b1w25ob5 797 1 and and CC cord-006856-b1w25ob5 797 2 BDCA3 BDCA3 NNP cord-006856-b1w25ob5 797 3 + + CC cord-006856-b1w25ob5 797 4 DCs dc NNS cord-006856-b1w25ob5 797 5 . . . cord-006856-b1w25ob5 798 1 Results result NNS cord-006856-b1w25ob5 798 2 . . . cord-006856-b1w25ob5 799 1 Induction induction NN cord-006856-b1w25ob5 799 2 with with IN cord-006856-b1w25ob5 799 3 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 799 4 led lead VBD cord-006856-b1w25ob5 799 5 to to IN cord-006856-b1w25ob5 799 6 a a DT cord-006856-b1w25ob5 799 7 strong strong JJ cord-006856-b1w25ob5 799 8 and and CC cord-006856-b1w25ob5 799 9 sustained sustained JJ cord-006856-b1w25ob5 799 10 reduction reduction NN cord-006856-b1w25ob5 799 11 of of IN cord-006856-b1w25ob5 799 12 the the DT cord-006856-b1w25ob5 799 13 total total JJ cord-006856-b1w25ob5 799 14 number number NN cord-006856-b1w25ob5 799 15 of of IN cord-006856-b1w25ob5 799 16 peripheral peripheral JJ cord-006856-b1w25ob5 799 17 DCs dc NNS cord-006856-b1w25ob5 799 18 compared compare VBN cord-006856-b1w25ob5 799 19 to to IN cord-006856-b1w25ob5 799 20 controls control NNS cord-006856-b1w25ob5 799 21 . . . cord-006856-b1w25ob5 800 1 While while IN cord-006856-b1w25ob5 800 2 the the DT cord-006856-b1w25ob5 800 3 absolute absolute JJ cord-006856-b1w25ob5 800 4 number number NN cord-006856-b1w25ob5 800 5 of of IN cord-006856-b1w25ob5 800 6 peripheral peripheral JJ cord-006856-b1w25ob5 800 7 DCs dc NNS cord-006856-b1w25ob5 800 8 in in IN cord-006856-b1w25ob5 800 9 control control NN cord-006856-b1w25ob5 800 10 patients patient NNS cord-006856-b1w25ob5 800 11 recovered recover VBD cord-006856-b1w25ob5 800 12 within within IN cord-006856-b1w25ob5 800 13 6 6 CD cord-006856-b1w25ob5 800 14 months month NNS cord-006856-b1w25ob5 800 15 after after IN cord-006856-b1w25ob5 800 16 transplantation transplantation NN cord-006856-b1w25ob5 800 17 , , , cord-006856-b1w25ob5 800 18 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 800 19 - - HYPH cord-006856-b1w25ob5 800 20 treated treat VBN cord-006856-b1w25ob5 800 21 patients patient NNS cord-006856-b1w25ob5 800 22 exhibited exhibit VBD cord-006856-b1w25ob5 800 23 a a DT cord-006856-b1w25ob5 800 24 profound profound JJ cord-006856-b1w25ob5 800 25 reduction reduction NN cord-006856-b1w25ob5 800 26 of of IN cord-006856-b1w25ob5 800 27 their -PRON- PRP$ cord-006856-b1w25ob5 800 28 circulating circulate VBG cord-006856-b1w25ob5 800 29 DCs dc NNS cord-006856-b1w25ob5 800 30 . . . cord-006856-b1w25ob5 801 1 Interestingly interestingly RB cord-006856-b1w25ob5 801 2 , , , cord-006856-b1w25ob5 801 3 a a DT cord-006856-b1w25ob5 801 4 prominent prominent JJ cord-006856-b1w25ob5 801 5 shift shift NN cord-006856-b1w25ob5 801 6 of of IN cord-006856-b1w25ob5 801 7 the the DT cord-006856-b1w25ob5 801 8 ratio ratio NN cord-006856-b1w25ob5 801 9 of of IN cord-006856-b1w25ob5 801 10 myeloid myeloid NN cord-006856-b1w25ob5 801 11 to to TO cord-006856-b1w25ob5 801 12 plasmacytoid plasmacytoid NNP cord-006856-b1w25ob5 801 13 DC DC NNP cord-006856-b1w25ob5 801 14 subsets subset NNS cord-006856-b1w25ob5 801 15 ( ( -LRB- cord-006856-b1w25ob5 801 16 DC1 DC1 NNP cord-006856-b1w25ob5 801 17 / / SYM cord-006856-b1w25ob5 801 18 DC2 DC2 NNP cord-006856-b1w25ob5 801 19 ratio ratio NN cord-006856-b1w25ob5 801 20 ) ) -RRB- cord-006856-b1w25ob5 801 21 was be VBD cord-006856-b1w25ob5 801 22 observed observe VBN cord-006856-b1w25ob5 801 23 as as RB cord-006856-b1w25ob5 801 24 early early RB cord-006856-b1w25ob5 801 25 as as IN cord-006856-b1w25ob5 801 26 one one CD cord-006856-b1w25ob5 801 27 month month NN cord-006856-b1w25ob5 801 28 after after IN cord-006856-b1w25ob5 801 29 transplantation transplantation NN cord-006856-b1w25ob5 801 30 in in IN cord-006856-b1w25ob5 801 31 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 801 32 - - HYPH cord-006856-b1w25ob5 801 33 treated treat VBN cord-006856-b1w25ob5 801 34 patients patient NNS cord-006856-b1w25ob5 801 35 . . . cord-006856-b1w25ob5 802 1 Conclusions conclusion NNS cord-006856-b1w25ob5 802 2 . . . cord-006856-b1w25ob5 803 1 Employment employment NN cord-006856-b1w25ob5 803 2 of of IN cord-006856-b1w25ob5 803 3 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 803 4 as as IN cord-006856-b1w25ob5 803 5 induction induction NN cord-006856-b1w25ob5 803 6 therapy therapy NN cord-006856-b1w25ob5 803 7 in in IN cord-006856-b1w25ob5 803 8 renal renal JJ cord-006856-b1w25ob5 803 9 transplant transplant NN cord-006856-b1w25ob5 803 10 patients patient NNS cord-006856-b1w25ob5 803 11 is be VBZ cord-006856-b1w25ob5 803 12 associated associate VBN cord-006856-b1w25ob5 803 13 with with IN cord-006856-b1w25ob5 803 14 a a DT cord-006856-b1w25ob5 803 15 peculiar peculiar JJ cord-006856-b1w25ob5 803 16 alteration alteration NN cord-006856-b1w25ob5 803 17 of of IN cord-006856-b1w25ob5 803 18 the the DT cord-006856-b1w25ob5 803 19 peripheral peripheral JJ cord-006856-b1w25ob5 803 20 DC DC NNP cord-006856-b1w25ob5 803 21 repertoire repertoire NN cord-006856-b1w25ob5 803 22 . . . cord-006856-b1w25ob5 804 1 Since since IN cord-006856-b1w25ob5 804 2 plasmacytoid plasmacytoid NNP cord-006856-b1w25ob5 804 3 DCs DCs NNP cord-006856-b1w25ob5 804 4 have have VBP cord-006856-b1w25ob5 804 5 been be VBN cord-006856-b1w25ob5 804 6 linked link VBN cord-006856-b1w25ob5 804 7 to to IN cord-006856-b1w25ob5 804 8 tolerance tolerance NN cord-006856-b1w25ob5 804 9 induction induction NN cord-006856-b1w25ob5 804 10 , , , cord-006856-b1w25ob5 804 11 the the DT cord-006856-b1w25ob5 804 12 presented present VBN cord-006856-b1w25ob5 804 13 data datum NNS cord-006856-b1w25ob5 804 14 suggest suggest VBP cord-006856-b1w25ob5 804 15 that that IN cord-006856-b1w25ob5 804 16 the the DT cord-006856-b1w25ob5 804 17 use use NN cord-006856-b1w25ob5 804 18 of of IN cord-006856-b1w25ob5 804 19 CAMPATH-1H CAMPATH-1H NNP cord-006856-b1w25ob5 804 20 in in IN cord-006856-b1w25ob5 804 21 solidorgan solidorgan JJ cord-006856-b1w25ob5 804 22 transplantation transplantation NN cord-006856-b1w25ob5 804 23 creates create VBZ cord-006856-b1w25ob5 804 24 an an DT cord-006856-b1w25ob5 804 25 opportunity opportunity NN cord-006856-b1w25ob5 804 26 to to TO cord-006856-b1w25ob5 804 27 safely safely RB cord-006856-b1w25ob5 804 28 introduce introduce VB cord-006856-b1w25ob5 804 29 novel novel JJ cord-006856-b1w25ob5 804 30 strategies strategy NNS cord-006856-b1w25ob5 804 31 to to TO cord-006856-b1w25ob5 804 32 achieve achieve VB cord-006856-b1w25ob5 804 33 alloantigen alloantigen NN cord-006856-b1w25ob5 804 34 - - HYPH cord-006856-b1w25ob5 804 35 specific specific JJ cord-006856-b1w25ob5 804 36 hyporesponsiveness hyporesponsiveness NN cord-006856-b1w25ob5 804 37 . . . cord-006856-b1w25ob5 805 1 Background background NN cord-006856-b1w25ob5 805 2 . . . cord-006856-b1w25ob5 806 1 Detection detection NN cord-006856-b1w25ob5 806 2 of of IN cord-006856-b1w25ob5 806 3 C4 c4 NN cord-006856-b1w25ob5 806 4 complement complement NN cord-006856-b1w25ob5 806 5 split split NN cord-006856-b1w25ob5 806 6 product product NN cord-006856-b1w25ob5 806 7 C4d C4d NNP cord-006856-b1w25ob5 806 8 in in IN cord-006856-b1w25ob5 806 9 peritubular peritubular NNP cord-006856-b1w25ob5 806 10 capillaries capillary NNS cord-006856-b1w25ob5 806 11 represents represent VBZ cord-006856-b1w25ob5 806 12 a a DT cord-006856-b1w25ob5 806 13 valuable valuable JJ cord-006856-b1w25ob5 806 14 diagnostic diagnostic JJ cord-006856-b1w25ob5 806 15 marker marker NN cord-006856-b1w25ob5 806 16 for for IN cord-006856-b1w25ob5 806 17 antibody antibody NN cord-006856-b1w25ob5 806 18 - - HYPH cord-006856-b1w25ob5 806 19 mediated mediate VBN cord-006856-b1w25ob5 806 20 rejection rejection NN cord-006856-b1w25ob5 806 21 ( ( -LRB- cord-006856-b1w25ob5 806 22 AMR AMR NNP cord-006856-b1w25ob5 806 23 ) ) -RRB- cord-006856-b1w25ob5 806 24 . . . cord-006856-b1w25ob5 807 1 Numerous numerous JJ cord-006856-b1w25ob5 807 2 studies study NNS cord-006856-b1w25ob5 807 3 have have VBP cord-006856-b1w25ob5 807 4 demonstrated demonstrate VBN cord-006856-b1w25ob5 807 5 inferior inferior JJ cord-006856-b1w25ob5 807 6 allograft allograft NN cord-006856-b1w25ob5 807 7 function function NN cord-006856-b1w25ob5 807 8 and and CC cord-006856-b1w25ob5 807 9 survival survival NN cord-006856-b1w25ob5 807 10 in in IN cord-006856-b1w25ob5 807 11 C4d C4d NNP cord-006856-b1w25ob5 807 12 - - HYPH cord-006856-b1w25ob5 807 13 positive positive JJ cord-006856-b1w25ob5 807 14 as as IN cord-006856-b1w25ob5 807 15 compared compare VBN cord-006856-b1w25ob5 807 16 with with IN cord-006856-b1w25ob5 807 17 C4d c4d JJ cord-006856-b1w25ob5 807 18 - - HYPH cord-006856-b1w25ob5 807 19 negative negative JJ cord-006856-b1w25ob5 807 20 kidney kidney NN cord-006856-b1w25ob5 807 21 allograft allograft NN cord-006856-b1w25ob5 807 22 recipients recipient NNS cord-006856-b1w25ob5 807 23 . . . cord-006856-b1w25ob5 808 1 However however RB cord-006856-b1w25ob5 808 2 , , , cord-006856-b1w25ob5 808 3 anecdotal anecdotal JJ cord-006856-b1w25ob5 808 4 data datum NNS cord-006856-b1w25ob5 808 5 implicate implicate VBP cord-006856-b1w25ob5 808 6 that that IN cord-006856-b1w25ob5 808 7 in in IN cord-006856-b1w25ob5 808 8 selected select VBN cord-006856-b1w25ob5 808 9 cases case NNS cord-006856-b1w25ob5 808 10 stable stable JJ cord-006856-b1w25ob5 808 11 long long JJ cord-006856-b1w25ob5 808 12 - - HYPH cord-006856-b1w25ob5 808 13 term term NN cord-006856-b1w25ob5 808 14 function function NN cord-006856-b1w25ob5 808 15 can can MD cord-006856-b1w25ob5 808 16 be be VB cord-006856-b1w25ob5 808 17 maintained maintain VBN cord-006856-b1w25ob5 808 18 despite despite IN cord-006856-b1w25ob5 808 19 detectable detectable JJ cord-006856-b1w25ob5 808 20 C4d C4d NNP cord-006856-b1w25ob5 808 21 deposits deposit NNS cord-006856-b1w25ob5 808 22 . . . cord-006856-b1w25ob5 809 1 As as IN cord-006856-b1w25ob5 809 2 recently recently RB cord-006856-b1w25ob5 809 3 dicussed dicusse VBN cord-006856-b1w25ob5 809 4 in in IN cord-006856-b1w25ob5 809 5 the the DT cord-006856-b1w25ob5 809 6 literature literature NN cord-006856-b1w25ob5 809 7 , , , cord-006856-b1w25ob5 809 8 C4d C4d NNP cord-006856-b1w25ob5 809 9 deposits deposit NNS cord-006856-b1w25ob5 809 10 could could MD cord-006856-b1w25ob5 809 11 also also RB cord-006856-b1w25ob5 809 12 reflect reflect VB cord-006856-b1w25ob5 809 13 a a DT cord-006856-b1w25ob5 809 14 state state NN cord-006856-b1w25ob5 809 15 of of IN cord-006856-b1w25ob5 809 16 graft graft NN cord-006856-b1w25ob5 809 17 acceptance acceptance NN cord-006856-b1w25ob5 809 18 ( ( -LRB- cord-006856-b1w25ob5 809 19 accommodation accommodation NN cord-006856-b1w25ob5 809 20 ) ) -RRB- cord-006856-b1w25ob5 809 21 , , , cord-006856-b1w25ob5 809 22 rather rather RB cord-006856-b1w25ob5 809 23 than than IN cord-006856-b1w25ob5 809 24 rejection rejection NN cord-006856-b1w25ob5 809 25 . . . cord-006856-b1w25ob5 810 1 Aim aim VB cord-006856-b1w25ob5 810 2 . . . cord-006856-b1w25ob5 811 1 The the DT cord-006856-b1w25ob5 811 2 objective objective NN cord-006856-b1w25ob5 811 3 of of IN cord-006856-b1w25ob5 811 4 this this DT cord-006856-b1w25ob5 811 5 study study NN cord-006856-b1w25ob5 811 6 was be VBD cord-006856-b1w25ob5 811 7 to to TO cord-006856-b1w25ob5 811 8 investigate investigate VB cord-006856-b1w25ob5 811 9 individual individual JJ cord-006856-b1w25ob5 811 10 clinical clinical JJ cord-006856-b1w25ob5 811 11 outcomes outcome NNS cord-006856-b1w25ob5 811 12 in in IN cord-006856-b1w25ob5 811 13 a a DT cord-006856-b1w25ob5 811 14 large large JJ cord-006856-b1w25ob5 811 15 cohort cohort NN cord-006856-b1w25ob5 811 16 of of IN cord-006856-b1w25ob5 811 17 C4d C4d NNP cord-006856-b1w25ob5 811 18 - - HYPH cord-006856-b1w25ob5 811 19 positive positive JJ cord-006856-b1w25ob5 811 20 kidney kidney NN cord-006856-b1w25ob5 811 21 transplant transplant NN cord-006856-b1w25ob5 811 22 recipients recipient NNS cord-006856-b1w25ob5 811 23 . . . cord-006856-b1w25ob5 812 1 Our -PRON- PRP$ cord-006856-b1w25ob5 812 2 emphasis emphasis NN cord-006856-b1w25ob5 812 3 was be VBD cord-006856-b1w25ob5 812 4 thereby thereby RB cord-006856-b1w25ob5 812 5 to to TO cord-006856-b1w25ob5 812 6 identify identify VB cord-006856-b1w25ob5 812 7 and and CC cord-006856-b1w25ob5 812 8 characterize characterize VB cord-006856-b1w25ob5 812 9 a a DT cord-006856-b1w25ob5 812 10 subpopulation subpopulation NN cord-006856-b1w25ob5 812 11 of of IN cord-006856-b1w25ob5 812 12 C4d C4d NNP cord-006856-b1w25ob5 812 13 - - HYPH cord-006856-b1w25ob5 812 14 positive positive JJ cord-006856-b1w25ob5 812 15 recipients recipient NNS cord-006856-b1w25ob5 812 16 with with IN cord-006856-b1w25ob5 812 17 only only JJ cord-006856-b1w25ob5 812 18 mild mild JJ cord-006856-b1w25ob5 812 19 graft graft NN cord-006856-b1w25ob5 812 20 dysfunction dysfunction NN cord-006856-b1w25ob5 812 21 and and CC cord-006856-b1w25ob5 812 22 stable stable JJ cord-006856-b1w25ob5 812 23 long long JJ cord-006856-b1w25ob5 812 24 - - HYPH cord-006856-b1w25ob5 812 25 term term NN cord-006856-b1w25ob5 812 26 graft graft NN cord-006856-b1w25ob5 812 27 function function NN cord-006856-b1w25ob5 812 28 . . . cord-006856-b1w25ob5 813 1 Methods method NNS cord-006856-b1w25ob5 813 2 . . . cord-006856-b1w25ob5 814 1 This this DT cord-006856-b1w25ob5 814 2 retrospective retrospective JJ cord-006856-b1w25ob5 814 3 analysis analysis NN cord-006856-b1w25ob5 814 4 focused focus VBD cord-006856-b1w25ob5 814 5 on on IN cord-006856-b1w25ob5 814 6 74 74 CD cord-006856-b1w25ob5 814 7 out out IN cord-006856-b1w25ob5 814 8 of of IN cord-006856-b1w25ob5 814 9 878 878 CD cord-006856-b1w25ob5 814 10 adult adult NN cord-006856-b1w25ob5 814 11 kidney kidney NN cord-006856-b1w25ob5 814 12 transplant transplant NN cord-006856-b1w25ob5 814 13 recipients recipient NNS cord-006856-b1w25ob5 814 14 ( ( -LRB- cord-006856-b1w25ob5 814 15 transplantation transplantation NN cord-006856-b1w25ob5 814 16 between between IN cord-006856-b1w25ob5 814 17 between between IN cord-006856-b1w25ob5 814 18 1999 1999 CD cord-006856-b1w25ob5 814 19 and and CC cord-006856-b1w25ob5 814 20 2003 2003 CD cord-006856-b1w25ob5 814 21 ) ) -RRB- cord-006856-b1w25ob5 814 22 included include VBD cord-006856-b1w25ob5 814 23 on on IN cord-006856-b1w25ob5 814 24 the the DT cord-006856-b1w25ob5 814 25 basis basis NN cord-006856-b1w25ob5 814 26 of of IN cord-006856-b1w25ob5 814 27 a a DT cord-006856-b1w25ob5 814 28 positive positive JJ cord-006856-b1w25ob5 814 29 C4d C4d NNP cord-006856-b1w25ob5 814 30 result result VB cord-006856-b1w25ob5 814 31 early early RB cord-006856-b1w25ob5 814 32 after after IN cord-006856-b1w25ob5 814 33 transplantation transplantation NN cord-006856-b1w25ob5 814 34 . . . cord-006856-b1w25ob5 815 1 Results result NNS cord-006856-b1w25ob5 815 2 . . . cord-006856-b1w25ob5 816 1 At at IN cord-006856-b1w25ob5 816 2 the the DT cord-006856-b1w25ob5 816 3 time time NN cord-006856-b1w25ob5 816 4 of of IN cord-006856-b1w25ob5 816 5 C4d C4d NNP cord-006856-b1w25ob5 816 6 - - HYPH cord-006856-b1w25ob5 816 7 positive positive JJ cord-006856-b1w25ob5 816 8 biopsy biopsy NN cord-006856-b1w25ob5 816 9 ( ( -LRB- cord-006856-b1w25ob5 816 10 median median NN cord-006856-b1w25ob5 816 11 , , , cord-006856-b1w25ob5 816 12 12 12 CD cord-006856-b1w25ob5 816 13 days day NNS cord-006856-b1w25ob5 816 14 post post NNP cord-006856-b1w25ob5 816 15 - - NNP cord-006856-b1w25ob5 816 16 Tx Tx NNP cord-006856-b1w25ob5 816 17 ) ) -RRB- cord-006856-b1w25ob5 817 1 median median JJ cord-006856-b1w25ob5 817 2 serum serum NN cord-006856-b1w25ob5 817 3 creatinine creatinine NN cord-006856-b1w25ob5 817 4 was be VBD cord-006856-b1w25ob5 817 5 6 6 CD cord-006856-b1w25ob5 817 6 mg mg NNP cord-006856-b1w25ob5 817 7 / / SYM cord-006856-b1w25ob5 817 8 dl dl NN cord-006856-b1w25ob5 817 9 ( ( -LRB- cord-006856-b1w25ob5 817 10 range range NN cord-006856-b1w25ob5 817 11 , , , cord-006856-b1w25ob5 817 12 1.1 1.1 CD cord-006856-b1w25ob5 817 13 to to TO cord-006856-b1w25ob5 817 14 7 7 CD cord-006856-b1w25ob5 817 15 mg mg NNP cord-006856-b1w25ob5 817 16 / / SYM cord-006856-b1w25ob5 817 17 dl dl NNP cord-006856-b1w25ob5 817 18 ) ) -RRB- cord-006856-b1w25ob5 817 19 with with IN cord-006856-b1w25ob5 817 20 49 49 CD cord-006856-b1w25ob5 817 21 % % NN cord-006856-b1w25ob5 817 22 of of IN cord-006856-b1w25ob5 817 23 the the DT cord-006856-b1w25ob5 817 24 patients patient NNS cord-006856-b1w25ob5 817 25 dialysis dialysis NN cord-006856-b1w25ob5 817 26 - - HYPH cord-006856-b1w25ob5 817 27 dependent dependent JJ cord-006856-b1w25ob5 817 28 . . . cord-006856-b1w25ob5 818 1 According accord VBG cord-006856-b1w25ob5 818 2 to to IN cord-006856-b1w25ob5 818 3 our -PRON- PRP$ cord-006856-b1w25ob5 818 4 local local JJ cord-006856-b1w25ob5 818 5 standard standard NN cord-006856-b1w25ob5 818 6 , , , cord-006856-b1w25ob5 818 7 patients patient NNS cord-006856-b1w25ob5 818 8 with with IN cord-006856-b1w25ob5 818 9 severe severe JJ cord-006856-b1w25ob5 818 10 graft graft NN cord-006856-b1w25ob5 818 11 dysfunction dysfunction NN cord-006856-b1w25ob5 819 1 ( ( -LRB- cord-006856-b1w25ob5 819 2 N n NN cord-006856-b1w25ob5 819 3 = = SYM cord-006856-b1w25ob5 819 4 15 15 CD cord-006856-b1w25ob5 819 5 ) ) -RRB- cord-006856-b1w25ob5 819 6 were be VBD cord-006856-b1w25ob5 819 7 subject subject JJ cord-006856-b1w25ob5 819 8 to to IN cord-006856-b1w25ob5 819 9 immunoadsorption immunoadsorption NN cord-006856-b1w25ob5 819 10 treatment treatment NN cord-006856-b1w25ob5 819 11 ( ( -LRB- cord-006856-b1w25ob5 819 12 IA IA NNP cord-006856-b1w25ob5 819 13 ) ) -RRB- cord-006856-b1w25ob5 819 14 . . . cord-006856-b1w25ob5 820 1 In in IN cord-006856-b1w25ob5 820 2 another another DT cord-006856-b1w25ob5 820 3 20 20 CD cord-006856-b1w25ob5 820 4 highly highly RB cord-006856-b1w25ob5 820 5 sensitized sensitize VBN cord-006856-b1w25ob5 820 6 recipients recipient NNS cord-006856-b1w25ob5 820 7 , , , cord-006856-b1w25ob5 820 8 C4d C4d NNP cord-006856-b1w25ob5 820 9 - - HYPH cord-006856-b1w25ob5 820 10 positive positive JJ cord-006856-b1w25ob5 820 11 graft graft NN cord-006856-b1w25ob5 820 12 dysfunction dysfunction NN cord-006856-b1w25ob5 820 13 was be VBD cord-006856-b1w25ob5 820 14 diagnosed diagnose VBN cord-006856-b1w25ob5 820 15 during during IN cord-006856-b1w25ob5 820 16 or or CC cord-006856-b1w25ob5 820 17 after after IN cord-006856-b1w25ob5 820 18 pre pre JJ cord-006856-b1w25ob5 820 19 - - JJ cord-006856-b1w25ob5 820 20 emptive emptive JJ cord-006856-b1w25ob5 820 21 peritransplant peritransplant NN cord-006856-b1w25ob5 820 22 IA IA NNP cord-006856-b1w25ob5 820 23 . . . cord-006856-b1w25ob5 821 1 Furthermore furthermore RB cord-006856-b1w25ob5 821 2 , , , cord-006856-b1w25ob5 821 3 intense intense JJ cord-006856-b1w25ob5 821 4 treatment treatment NN cord-006856-b1w25ob5 821 5 included include VBD cord-006856-b1w25ob5 821 6 antilymphocyte antilymphocyte NNP cord-006856-b1w25ob5 821 7 antibody antibody NN cord-006856-b1w25ob5 821 8 therapy therapy NN cord-006856-b1w25ob5 821 9 ( ( -LRB- cord-006856-b1w25ob5 821 10 32 32 CD cord-006856-b1w25ob5 821 11 % % NN cord-006856-b1w25ob5 821 12 ) ) -RRB- cord-006856-b1w25ob5 822 1 and/or and/or CC cord-006856-b1w25ob5 822 2 high high JJ cord-006856-b1w25ob5 822 3 - - HYPH cord-006856-b1w25ob5 822 4 dose dose NN cord-006856-b1w25ob5 822 5 steroids steroid NNS cord-006856-b1w25ob5 822 6 in in IN cord-006856-b1w25ob5 822 7 a a DT cord-006856-b1w25ob5 822 8 high high JJ cord-006856-b1w25ob5 822 9 proportion proportion NN cord-006856-b1w25ob5 822 10 of of IN cord-006856-b1w25ob5 822 11 C4d c4d JJ cord-006856-b1w25ob5 822 12 - - HYPH cord-006856-b1w25ob5 822 13 positive positive JJ cord-006856-b1w25ob5 822 14 recipients recipient NNS cord-006856-b1w25ob5 822 15 ( ( -LRB- cord-006856-b1w25ob5 822 16 46 46 CD cord-006856-b1w25ob5 822 17 % % NN cord-006856-b1w25ob5 822 18 ) ) -RRB- cord-006856-b1w25ob5 822 19 . . . cord-006856-b1w25ob5 823 1 Analyzing analyze VBG cord-006856-b1w25ob5 823 2 all all DT cord-006856-b1w25ob5 823 3 74 74 CD cord-006856-b1w25ob5 823 4 C4d c4d JJ cord-006856-b1w25ob5 823 5 - - HYPH cord-006856-b1w25ob5 823 6 positive positive JJ cord-006856-b1w25ob5 823 7 recipients recipient NNS cord-006856-b1w25ob5 823 8 , , , cord-006856-b1w25ob5 823 9 1-month 1-month CD cord-006856-b1w25ob5 823 10 post post JJ cord-006856-b1w25ob5 823 11 - - JJ cord-006856-b1w25ob5 823 12 biopsy biopsy JJ cord-006856-b1w25ob5 823 13 se se FW cord-006856-b1w25ob5 823 14 - - HYPH cord-006856-b1w25ob5 823 15 rum rum NN cord-006856-b1w25ob5 823 16 creatinine creatinine NN cord-006856-b1w25ob5 823 17 was be VBD cord-006856-b1w25ob5 823 18 2.1 2.1 CD cord-006856-b1w25ob5 823 19 mg mg NNP cord-006856-b1w25ob5 823 20 / / SYM cord-006856-b1w25ob5 823 21 dl dl NNP cord-006856-b1w25ob5 823 22 ( ( -LRB- cord-006856-b1w25ob5 823 23 30 30 CD cord-006856-b1w25ob5 823 24 % % NN cord-006856-b1w25ob5 823 25 of of IN cord-006856-b1w25ob5 823 26 the the DT cord-006856-b1w25ob5 823 27 patients patient NNS cord-006856-b1w25ob5 823 28 dialysis dialysis NN cord-006856-b1w25ob5 823 29 - - HYPH cord-006856-b1w25ob5 823 30 dependent dependent JJ cord-006856-b1w25ob5 823 31 ) ) -RRB- cord-006856-b1w25ob5 823 32 . . . cord-006856-b1w25ob5 824 1 1-year 1-year CD cord-006856-b1w25ob5 824 2 graft graft NN cord-006856-b1w25ob5 824 3 and and CC cord-006856-b1w25ob5 824 4 patient patient JJ cord-006856-b1w25ob5 824 5 survival survival NN cord-006856-b1w25ob5 824 6 was be VBD cord-006856-b1w25ob5 824 7 73 73 CD cord-006856-b1w25ob5 824 8 % % NN cord-006856-b1w25ob5 824 9 ( ( -LRB- cord-006856-b1w25ob5 824 10 serum serum NN cord-006856-b1w25ob5 824 11 creatinine creatinine NN cord-006856-b1w25ob5 824 12 , , , cord-006856-b1w25ob5 824 13 1.84 1.84 CD cord-006856-b1w25ob5 824 14 mg mg NNP cord-006856-b1w25ob5 824 15 / / SYM cord-006856-b1w25ob5 824 16 dl dl NNP cord-006856-b1w25ob5 824 17 ) ) -RRB- cord-006856-b1w25ob5 824 18 . . . cord-006856-b1w25ob5 825 1 In in IN cord-006856-b1w25ob5 825 2 a a DT cord-006856-b1w25ob5 825 3 subsequent subsequent JJ cord-006856-b1w25ob5 825 4 subanalysis subanalysis NN cord-006856-b1w25ob5 825 5 we -PRON- PRP cord-006856-b1w25ob5 825 6 focused focus VBD cord-006856-b1w25ob5 825 7 on on IN cord-006856-b1w25ob5 825 8 twelve twelve CD cord-006856-b1w25ob5 825 9 patients patient NNS cord-006856-b1w25ob5 825 10 ( ( -LRB- cord-006856-b1w25ob5 825 11 two two CD cord-006856-b1w25ob5 825 12 were be VBD cord-006856-b1w25ob5 825 13 biopsied biopsie VBN cord-006856-b1w25ob5 825 14 under under IN cord-006856-b1w25ob5 825 15 IA IA NNP cord-006856-b1w25ob5 825 16 / / SYM cord-006856-b1w25ob5 825 17 ATG ATG NNP cord-006856-b1w25ob5 825 18 induction induction NN cord-006856-b1w25ob5 825 19 ) ) -RRB- cord-006856-b1w25ob5 825 20 with with IN cord-006856-b1w25ob5 825 21 only only RB cord-006856-b1w25ob5 825 22 mild mild JJ cord-006856-b1w25ob5 825 23 to to IN cord-006856-b1w25ob5 825 24 moderate moderate JJ cord-006856-b1w25ob5 825 25 graft graft NN cord-006856-b1w25ob5 825 26 dysfunction dysfunction NN cord-006856-b1w25ob5 825 27 ( ( -LRB- cord-006856-b1w25ob5 825 28 serum serum NN cord-006856-b1w25ob5 825 29 creatinine creatinine NN cord-006856-b1w25ob5 825 30 , , , cord-006856-b1w25ob5 825 31 1.4 1.4 CD cord-006856-b1w25ob5 825 32 to to IN cord-006856-b1w25ob5 825 33 2.45 2.45 CD cord-006856-b1w25ob5 825 34 mg mg NNP cord-006856-b1w25ob5 825 35 / / SYM cord-006856-b1w25ob5 825 36 dl dl NNP cord-006856-b1w25ob5 825 37 ) ) -RRB- cord-006856-b1w25ob5 825 38 at at IN cord-006856-b1w25ob5 825 39 the the DT cord-006856-b1w25ob5 825 40 time time NN cord-006856-b1w25ob5 825 41 of of IN cord-006856-b1w25ob5 825 42 C4d C4d NNP cord-006856-b1w25ob5 825 43 - - HYPH cord-006856-b1w25ob5 825 44 positive positive JJ cord-006856-b1w25ob5 825 45 biopsy biopsy NN cord-006856-b1w25ob5 825 46 ( ( -LRB- cord-006856-b1w25ob5 825 47 Banff Banff NNP cord-006856-b1w25ob5 825 48 borderline borderline JJ cord-006856-b1w25ob5 825 49 lesion lesion NN cord-006856-b1w25ob5 825 50 in in IN cord-006856-b1w25ob5 825 51 five five CD cord-006856-b1w25ob5 825 52 , , , cord-006856-b1w25ob5 825 53 and and CC cord-006856-b1w25ob5 825 54 Banff Banff NNP cord-006856-b1w25ob5 825 55 I -PRON- PRP cord-006856-b1w25ob5 825 56 rejection rejection NN cord-006856-b1w25ob5 825 57 in in IN cord-006856-b1w25ob5 825 58 two two CD cord-006856-b1w25ob5 825 59 biopsies biopsy NNS cord-006856-b1w25ob5 825 60 ) ) -RRB- cord-006856-b1w25ob5 825 61 . . . cord-006856-b1w25ob5 826 1 Within within IN cord-006856-b1w25ob5 826 2 this this DT cord-006856-b1w25ob5 826 3 patient patient NN cord-006856-b1w25ob5 826 4 subgroup subgroup NN cord-006856-b1w25ob5 826 5 , , , cord-006856-b1w25ob5 826 6 we -PRON- PRP cord-006856-b1w25ob5 826 7 were be VBD cord-006856-b1w25ob5 826 8 able able JJ cord-006856-b1w25ob5 826 9 to to TO cord-006856-b1w25ob5 826 10 identify identify VB cord-006856-b1w25ob5 826 11 five five CD cord-006856-b1w25ob5 826 12 recipients recipient NNS cord-006856-b1w25ob5 826 13 in in IN cord-006856-b1w25ob5 826 14 whom whom WP cord-006856-b1w25ob5 826 15 stable stable JJ cord-006856-b1w25ob5 826 16 long long JJ cord-006856-b1w25ob5 826 17 - - HYPH cord-006856-b1w25ob5 826 18 term term NN cord-006856-b1w25ob5 826 19 graft graft NN cord-006856-b1w25ob5 826 20 function function NN cord-006856-b1w25ob5 826 21 could could MD cord-006856-b1w25ob5 826 22 be be VB cord-006856-b1w25ob5 826 23 achieved achieve VBN cord-006856-b1w25ob5 826 24 following follow VBG cord-006856-b1w25ob5 826 25 steroid steroid JJ cord-006856-b1w25ob5 826 26 bolus bolus NN cord-006856-b1w25ob5 826 27 therapy therapy NN cord-006856-b1w25ob5 826 28 only only RB cord-006856-b1w25ob5 826 29 , , , cord-006856-b1w25ob5 826 30 without without IN cord-006856-b1w25ob5 826 31 further further JJ cord-006856-b1w25ob5 826 32 therapeutic therapeutic JJ cord-006856-b1w25ob5 826 33 measures measure NNS cord-006856-b1w25ob5 826 34 . . . cord-006856-b1w25ob5 827 1 In in IN cord-006856-b1w25ob5 827 2 this this DT cord-006856-b1w25ob5 827 3 particular particular JJ cord-006856-b1w25ob5 827 4 subgroup subgroup NN cord-006856-b1w25ob5 827 5 excellent excellent JJ cord-006856-b1w25ob5 827 6 1-year 1-year CD cord-006856-b1w25ob5 827 7 allograft allograft NN cord-006856-b1w25ob5 827 8 function function NN cord-006856-b1w25ob5 827 9 ( ( -LRB- cord-006856-b1w25ob5 827 10 serum serum NN cord-006856-b1w25ob5 827 11 creatinine creatinine NN cord-006856-b1w25ob5 827 12 levels level NNS cord-006856-b1w25ob5 827 13 between between IN cord-006856-b1w25ob5 827 14 1.0 1.0 CD cord-006856-b1w25ob5 827 15 to to TO cord-006856-b1w25ob5 827 16 1.8 1.8 CD cord-006856-b1w25ob5 827 17 mg mg NNP cord-006856-b1w25ob5 827 18 / / SYM cord-006856-b1w25ob5 827 19 dl dl NNP cord-006856-b1w25ob5 827 20 ) ) -RRB- cord-006856-b1w25ob5 827 21 was be VBD cord-006856-b1w25ob5 827 22 observed observe VBN cord-006856-b1w25ob5 827 23 . . . cord-006856-b1w25ob5 828 1 Conclusions conclusion NNS cord-006856-b1w25ob5 828 2 . . . cord-006856-b1w25ob5 829 1 Our -PRON- PRP$ cord-006856-b1w25ob5 829 2 results result NNS cord-006856-b1w25ob5 829 3 demonstrate demonstrate VBP cord-006856-b1w25ob5 829 4 that that IN cord-006856-b1w25ob5 829 5 in in IN cord-006856-b1w25ob5 829 6 the the DT cord-006856-b1w25ob5 829 7 majority majority NN cord-006856-b1w25ob5 829 8 of of IN cord-006856-b1w25ob5 829 9 patients patient NNS cord-006856-b1w25ob5 829 10 peritubular peritubular NNP cord-006856-b1w25ob5 829 11 capillary capillary JJ cord-006856-b1w25ob5 829 12 C4d C4d NNP cord-006856-b1w25ob5 829 13 deposits deposit NNS cord-006856-b1w25ob5 829 14 are be VBP cord-006856-b1w25ob5 829 15 associated associate VBN cord-006856-b1w25ob5 829 16 with with IN cord-006856-b1w25ob5 829 17 severe severe JJ cord-006856-b1w25ob5 829 18 graft graft NN cord-006856-b1w25ob5 829 19 dysfunction dysfunction NN cord-006856-b1w25ob5 829 20 necessitating necessitate VBG cord-006856-b1w25ob5 829 21 aggressive aggressive JJ cord-006856-b1w25ob5 829 22 treatment treatment NN cord-006856-b1w25ob5 829 23 . . . cord-006856-b1w25ob5 830 1 Nevertheless nevertheless RB cord-006856-b1w25ob5 830 2 , , , cord-006856-b1w25ob5 830 3 in in IN cord-006856-b1w25ob5 830 4 a a DT cord-006856-b1w25ob5 830 5 small small JJ cord-006856-b1w25ob5 830 6 subgroup subgroup NN cord-006856-b1w25ob5 830 7 of of IN cord-006856-b1w25ob5 830 8 recipients recipient NNS cord-006856-b1w25ob5 830 9 stable stable JJ cord-006856-b1w25ob5 830 10 graft graft NN cord-006856-b1w25ob5 830 11 function function NN cord-006856-b1w25ob5 830 12 for for IN cord-006856-b1w25ob5 830 13 a a DT cord-006856-b1w25ob5 830 14 long long JJ cord-006856-b1w25ob5 830 15 period period NN cord-006856-b1w25ob5 830 16 of of IN cord-006856-b1w25ob5 830 17 time time NN cord-006856-b1w25ob5 830 18 can can MD cord-006856-b1w25ob5 830 19 be be VB cord-006856-b1w25ob5 830 20 achieved achieve VBN cord-006856-b1w25ob5 830 21 without without IN cord-006856-b1w25ob5 830 22 intense intense JJ cord-006856-b1w25ob5 830 23 therapy therapy NN cord-006856-b1w25ob5 830 24 despite despite IN cord-006856-b1w25ob5 830 25 capillary capillary JJ cord-006856-b1w25ob5 830 26 C4d C4d NNP cord-006856-b1w25ob5 830 27 deposition deposition NN cord-006856-b1w25ob5 830 28 in in IN cord-006856-b1w25ob5 830 29 biopsy biopsy NN cord-006856-b1w25ob5 830 30 . . . cord-006856-b1w25ob5 831 1 Background background NN cord-006856-b1w25ob5 831 2 . . . cord-006856-b1w25ob5 832 1 Combined combined JJ cord-006856-b1w25ob5 832 2 kidney kidney NN cord-006856-b1w25ob5 832 3 pancreas pancrea VBZ cord-006856-b1w25ob5 832 4 transplantation transplantation NN cord-006856-b1w25ob5 832 5 ( ( -LRB- cord-006856-b1w25ob5 832 6 PTx PTx NNS cord-006856-b1w25ob5 832 7 ) ) -RRB- cord-006856-b1w25ob5 832 8 evolved evolve VBD cord-006856-b1w25ob5 832 9 as as IN cord-006856-b1w25ob5 832 10 excellent excellent JJ cord-006856-b1w25ob5 832 11 treatment treatment NN cord-006856-b1w25ob5 832 12 for for IN cord-006856-b1w25ob5 832 13 diabetic diabetic JJ cord-006856-b1w25ob5 832 14 nephropathy nephropathy NN cord-006856-b1w25ob5 832 15 with with IN cord-006856-b1w25ob5 832 16 infections infection NNS cord-006856-b1w25ob5 832 17 remaining remain VBG cord-006856-b1w25ob5 832 18 common common JJ cord-006856-b1w25ob5 832 19 and and CC cord-006856-b1w25ob5 832 20 serious serious JJ cord-006856-b1w25ob5 832 21 complications complication NNS cord-006856-b1w25ob5 832 22 . . . cord-006856-b1w25ob5 833 1 Methods method NNS cord-006856-b1w25ob5 833 2 . . . cord-006856-b1w25ob5 834 1 217 217 CD cord-006856-b1w25ob5 834 2 consecutive consecutive JJ cord-006856-b1w25ob5 834 3 enteric enteric NN cord-006856-b1w25ob5 834 4 drained drain VBD cord-006856-b1w25ob5 834 5 PTxs PTxs NNP cord-006856-b1w25ob5 834 6 performed perform VBD cord-006856-b1w25ob5 834 7 from from IN cord-006856-b1w25ob5 834 8 1997 1997 CD cord-006856-b1w25ob5 834 9 to to IN cord-006856-b1w25ob5 834 10 2004 2004 CD cord-006856-b1w25ob5 834 11 were be VBD cord-006856-b1w25ob5 834 12 retrospectively retrospectively RB cord-006856-b1w25ob5 834 13 analyzed analyze VBN cord-006856-b1w25ob5 834 14 with with IN cord-006856-b1w25ob5 834 15 regard regard NN cord-006856-b1w25ob5 834 16 to to IN cord-006856-b1w25ob5 834 17 bloodstream bloodstream NN cord-006856-b1w25ob5 834 18 infection infection NN cord-006856-b1w25ob5 834 19 . . . cord-006856-b1w25ob5 835 1 Immunosuppression Immunosuppression NNP cord-006856-b1w25ob5 835 2 consisted consist VBD cord-006856-b1w25ob5 835 3 of of IN cord-006856-b1w25ob5 835 4 antithymocyteglobuline antithymocyteglobuline JJ cord-006856-b1w25ob5 835 5 induction induction NN cord-006856-b1w25ob5 835 6 , , , cord-006856-b1w25ob5 835 7 tacrolimus tacrolimus NNP cord-006856-b1w25ob5 835 8 , , , cord-006856-b1w25ob5 835 9 mycophenolic mycophenolic NNP cord-006856-b1w25ob5 835 10 acid acid NN cord-006856-b1w25ob5 835 11 , , , cord-006856-b1w25ob5 835 12 and and CC cord-006856-b1w25ob5 835 13 steroids steroid NNS cord-006856-b1w25ob5 835 14 for for IN cord-006856-b1w25ob5 835 15 the the DT cord-006856-b1w25ob5 835 16 majority majority NN cord-006856-b1w25ob5 835 17 of of IN cord-006856-b1w25ob5 835 18 cases case NNS cord-006856-b1w25ob5 835 19 . . . cord-006856-b1w25ob5 836 1 Standard standard JJ cord-006856-b1w25ob5 836 2 perioperative perioperative JJ cord-006856-b1w25ob5 836 3 antimicrobial antimicrobial JJ cord-006856-b1w25ob5 836 4 prophylaxis prophylaxis NN cord-006856-b1w25ob5 836 5 consisted consist VBN cord-006856-b1w25ob5 836 6 of of IN cord-006856-b1w25ob5 836 7 pipercillin pipercillin NNP cord-006856-b1w25ob5 836 8 / / SYM cord-006856-b1w25ob5 836 9 tazobactam tazobactam NNS cord-006856-b1w25ob5 836 10 in in IN cord-006856-b1w25ob5 836 11 combination combination NN cord-006856-b1w25ob5 836 12 with with IN cord-006856-b1w25ob5 836 13 ciprofloxacin ciprofloxacin NN cord-006856-b1w25ob5 836 14 and and CC cord-006856-b1w25ob5 836 15 fluconazole fluconazole NN cord-006856-b1w25ob5 836 16 . . . cord-006856-b1w25ob5 837 1 Results result NNS cord-006856-b1w25ob5 837 2 . . . cord-006856-b1w25ob5 838 1 One one CD cord-006856-b1w25ob5 838 2 - - HYPH cord-006856-b1w25ob5 838 3 year year NN cord-006856-b1w25ob5 838 4 patient patient NN cord-006856-b1w25ob5 838 5 , , , cord-006856-b1w25ob5 838 6 pancreas pancreas NN cord-006856-b1w25ob5 838 7 and and CC cord-006856-b1w25ob5 838 8 kidney kidney NN cord-006856-b1w25ob5 838 9 graft graft NN cord-006856-b1w25ob5 838 10 survival survival NN cord-006856-b1w25ob5 838 11 were be VBD cord-006856-b1w25ob5 838 12 96.4 96.4 CD cord-006856-b1w25ob5 838 13 % % NN cord-006856-b1w25ob5 838 14 , , , cord-006856-b1w25ob5 838 15 88.5 88.5 CD cord-006856-b1w25ob5 838 16 % % NN cord-006856-b1w25ob5 838 17 , , , cord-006856-b1w25ob5 838 18 and and CC cord-006856-b1w25ob5 838 19 94.8 94.8 CD cord-006856-b1w25ob5 838 20 % % NN cord-006856-b1w25ob5 838 21 , , , cord-006856-b1w25ob5 838 22 surgical surgical JJ cord-006856-b1w25ob5 838 23 complication complication NN cord-006856-b1w25ob5 838 24 rate rate NN cord-006856-b1w25ob5 838 25 was be VBD cord-006856-b1w25ob5 838 26 35 35 CD cord-006856-b1w25ob5 838 27 % % NN cord-006856-b1w25ob5 838 28 , , , cord-006856-b1w25ob5 838 29 rejection rejection NN cord-006856-b1w25ob5 838 30 rate rate NN cord-006856-b1w25ob5 838 31 30 30 CD cord-006856-b1w25ob5 838 32 % % NN cord-006856-b1w25ob5 838 33 , , , cord-006856-b1w25ob5 838 34 and and CC cord-006856-b1w25ob5 838 35 rate rate NN cord-006856-b1w25ob5 838 36 of of IN cord-006856-b1w25ob5 838 37 infection infection NN cord-006856-b1w25ob5 838 38 59 59 CD cord-006856-b1w25ob5 838 39 % % NN cord-006856-b1w25ob5 838 40 . . . cord-006856-b1w25ob5 839 1 In in IN cord-006856-b1w25ob5 839 2 total total JJ cord-006856-b1w25ob5 839 3 , , , cord-006856-b1w25ob5 839 4 46 46 CD cord-006856-b1w25ob5 839 5 sepsis sepsis NN cord-006856-b1w25ob5 839 6 episodes episode NNS cord-006856-b1w25ob5 839 7 were be VBD cord-006856-b1w25ob5 839 8 diagnosed diagnose VBN cord-006856-b1w25ob5 839 9 in in IN cord-006856-b1w25ob5 839 10 35 35 CD cord-006856-b1w25ob5 839 11 patients patient NNS cord-006856-b1w25ob5 839 12 ( ( -LRB- cord-006856-b1w25ob5 839 13 16 16 CD cord-006856-b1w25ob5 839 14 % % NN cord-006856-b1w25ob5 839 15 ) ) -RRB- cord-006856-b1w25ob5 839 16 with with IN cord-006856-b1w25ob5 839 17 a a DT cord-006856-b1w25ob5 839 18 median median JJ cord-006856-b1w25ob5 839 19 onset onset NN cord-006856-b1w25ob5 839 20 on on IN cord-006856-b1w25ob5 839 21 day day NN cord-006856-b1w25ob5 839 22 12 12 CD cord-006856-b1w25ob5 839 23 ( ( -LRB- cord-006856-b1w25ob5 839 24 range range NN cord-006856-b1w25ob5 839 25 , , , cord-006856-b1w25ob5 839 26 1 1 CD cord-006856-b1w25ob5 839 27 - - SYM cord-006856-b1w25ob5 839 28 45 45 CD cord-006856-b1w25ob5 839 29 ) ) -RRB- cord-006856-b1w25ob5 839 30 post post NN cord-006856-b1w25ob5 839 31 transplant transplant NN cord-006856-b1w25ob5 839 32 . . . cord-006856-b1w25ob5 840 1 Sepsis sepsis NN cord-006856-b1w25ob5 840 2 source source NN cord-006856-b1w25ob5 840 3 was be VBD cord-006856-b1w25ob5 840 4 intra intra JJ cord-006856-b1w25ob5 840 5 - - JJ cord-006856-b1w25ob5 840 6 abdominal abdominal JJ cord-006856-b1w25ob5 840 7 infection infection NN cord-006856-b1w25ob5 840 8 ( ( -LRB- cord-006856-b1w25ob5 840 9 IAI IAI NNP cord-006856-b1w25ob5 840 10 ) ) -RRB- cord-006856-b1w25ob5 841 1 ( ( -LRB- cord-006856-b1w25ob5 841 2 n n NN cord-006856-b1w25ob5 841 3 = = SYM cord-006856-b1w25ob5 841 4 21 21 CD cord-006856-b1w25ob5 841 5 ) ) -RRB- cord-006856-b1w25ob5 841 6 , , , cord-006856-b1w25ob5 841 7 a a DT cord-006856-b1w25ob5 841 8 contaminated contaminate VBN cord-006856-b1w25ob5 841 9 central central JJ cord-006856-b1w25ob5 841 10 venous venous JJ cord-006856-b1w25ob5 841 11 line line NN cord-006856-b1w25ob5 841 12 ( ( -LRB- cord-006856-b1w25ob5 841 13 n n NN cord-006856-b1w25ob5 841 14 = = SYM cord-006856-b1w25ob5 841 15 10 10 CD cord-006856-b1w25ob5 841 16 ) ) -RRB- cord-006856-b1w25ob5 841 17 , , , cord-006856-b1w25ob5 841 18 wound wound NN cord-006856-b1w25ob5 841 19 infection infection NN cord-006856-b1w25ob5 841 20 ( ( -LRB- cord-006856-b1w25ob5 841 21 n n NN cord-006856-b1w25ob5 841 22 = = SYM cord-006856-b1w25ob5 841 23 5 5 CD cord-006856-b1w25ob5 841 24 ) ) -RRB- cord-006856-b1w25ob5 841 25 , , , cord-006856-b1w25ob5 841 26 urinary urinary JJ cord-006856-b1w25ob5 841 27 tract tract NN cord-006856-b1w25ob5 841 28 infection infection NN cord-006856-b1w25ob5 841 29 ( ( -LRB- cord-006856-b1w25ob5 841 30 n n NN cord-006856-b1w25ob5 841 31 = = SYM cord-006856-b1w25ob5 841 32 2 2 CD cord-006856-b1w25ob5 841 33 ) ) -RRB- cord-006856-b1w25ob5 841 34 , , , cord-006856-b1w25ob5 841 35 and and CC cord-006856-b1w25ob5 841 36 graft graft NN cord-006856-b1w25ob5 841 37 transmitted transmit VBN cord-006856-b1w25ob5 841 38 ( ( -LRB- cord-006856-b1w25ob5 841 39 n n NN cord-006856-b1w25ob5 841 40 = = SYM cord-006856-b1w25ob5 841 41 2 2 CD cord-006856-b1w25ob5 841 42 ) ) -RRB- cord-006856-b1w25ob5 841 43 . . . cord-006856-b1w25ob5 842 1 Nine nine CD cord-006856-b1w25ob5 842 2 patients patient NNS cord-006856-b1w25ob5 842 3 ( ( -LRB- cord-006856-b1w25ob5 842 4 4 4 CD cord-006856-b1w25ob5 842 5 % % NN cord-006856-b1w25ob5 842 6 ) ) -RRB- cord-006856-b1w25ob5 842 7 experienced experience VBD cord-006856-b1w25ob5 842 8 multiple multiple JJ cord-006856-b1w25ob5 842 9 sepsis sepsis NN cord-006856-b1w25ob5 842 10 episodes episode NNS cord-006856-b1w25ob5 842 11 . . . cord-006856-b1w25ob5 843 1 Overall overall RB cord-006856-b1w25ob5 843 2 , , , cord-006856-b1w25ob5 843 3 65 65 CD cord-006856-b1w25ob5 843 4 pathogens pathogen NNS cord-006856-b1w25ob5 843 5 ( ( -LRB- cord-006856-b1w25ob5 843 6 IAI IAI NNP cord-006856-b1w25ob5 843 7 sepsis sepsis NN cord-006856-b1w25ob5 843 8 , , , cord-006856-b1w25ob5 843 9 39 39 CD cord-006856-b1w25ob5 843 10 ; ; : cord-006856-b1w25ob5 843 11 line line NN cord-006856-b1w25ob5 843 12 sepsis sepsis NN cord-006856-b1w25ob5 843 13 , , , cord-006856-b1w25ob5 843 14 15 15 CD cord-006856-b1w25ob5 843 15 ; ; : cord-006856-b1w25ob5 843 16 others other NNS cord-006856-b1w25ob5 843 17 , , , cord-006856-b1w25ob5 843 18 11 11 CD cord-006856-b1w25ob5 843 19 ) ) -RRB- cord-006856-b1w25ob5 843 20 were be VBD cord-006856-b1w25ob5 843 21 isolated isolate VBN cord-006856-b1w25ob5 843 22 from from IN cord-006856-b1w25ob5 843 23 blood blood NN cord-006856-b1w25ob5 843 24 . . . cord-006856-b1w25ob5 844 1 Gram gram NN cord-006856-b1w25ob5 844 2 - - HYPH cord-006856-b1w25ob5 844 3 positive positive JJ cord-006856-b1w25ob5 844 4 cocci coccus NNS cord-006856-b1w25ob5 844 5 accounted account VBD cord-006856-b1w25ob5 844 6 for for IN cord-006856-b1w25ob5 844 7 50 50 CD cord-006856-b1w25ob5 844 8 isolates isolate NNS cord-006856-b1w25ob5 844 9 ( ( -LRB- cord-006856-b1w25ob5 844 10 77 77 CD cord-006856-b1w25ob5 844 11 % % NN cord-006856-b1w25ob5 844 12 ) ) -RRB- cord-006856-b1w25ob5 844 13 : : : cord-006856-b1w25ob5 844 14 coagulase coagulase NNP cord-006856-b1w25ob5 844 15 negative negative JJ cord-006856-b1w25ob5 844 16 staphylococci staphylococcus NNS cord-006856-b1w25ob5 844 17 ( ( -LRB- cord-006856-b1w25ob5 844 18 n n NN cord-006856-b1w25ob5 844 19 = = SYM cord-006856-b1w25ob5 844 20 28 28 CD cord-006856-b1w25ob5 844 21 [ [ -LRB- cord-006856-b1w25ob5 844 22 43 43 CD cord-006856-b1w25ob5 844 23 % % NN cord-006856-b1w25ob5 844 24 ] ] -RRB- cord-006856-b1w25ob5 844 25 ) ) -RRB- cord-006856-b1w25ob5 844 26 ( ( -LRB- cord-006856-b1w25ob5 844 27 nine nine CD cord-006856-b1w25ob5 844 28 multiresistant multiresistant NN cord-006856-b1w25ob5 844 29 ) ) -RRB- cord-006856-b1w25ob5 844 30 , , , cord-006856-b1w25ob5 844 31 Staphylococcus Staphylococcus NNP cord-006856-b1w25ob5 844 32 aureus aureus NN cord-006856-b1w25ob5 844 33 ( ( -LRB- cord-006856-b1w25ob5 845 1 n n NN cord-006856-b1w25ob5 845 2 = = SYM cord-006856-b1w25ob5 845 3 11 11 CD cord-006856-b1w25ob5 845 4 [ [ -LRB- cord-006856-b1w25ob5 845 5 17 17 CD cord-006856-b1w25ob5 845 6 % % NN cord-006856-b1w25ob5 845 7 ] ] -RRB- cord-006856-b1w25ob5 845 8 ) ) -RRB- cord-006856-b1w25ob5 845 9 ( ( -LRB- cord-006856-b1w25ob5 845 10 four four CD cord-006856-b1w25ob5 845 11 multiresistant multiresistant NN cord-006856-b1w25ob5 845 12 ) ) -RRB- cord-006856-b1w25ob5 845 13 , , , cord-006856-b1w25ob5 845 14 enterococci enterococci NNP cord-006856-b1w25ob5 845 15 ( ( -LRB- cord-006856-b1w25ob5 845 16 n n NN cord-006856-b1w25ob5 845 17 = = SYM cord-006856-b1w25ob5 845 18 9 9 CD cord-006856-b1w25ob5 845 19 [ [ -LRB- cord-006856-b1w25ob5 845 20 14 14 CD cord-006856-b1w25ob5 845 21 % % NN cord-006856-b1w25ob5 845 22 ] ] -RRB- cord-006856-b1w25ob5 845 23 ) ) -RRB- cord-006856-b1w25ob5 846 1 ( ( -LRB- cord-006856-b1w25ob5 846 2 one one CD cord-006856-b1w25ob5 846 3 E. E. NNP cord-006856-b1w25ob5 846 4 faecium faecium NN cord-006856-b1w25ob5 846 5 ) ) -RRB- cord-006856-b1w25ob5 846 6 . . . cord-006856-b1w25ob5 847 1 Gram gram NN cord-006856-b1w25ob5 847 2 - - HYPH cord-006856-b1w25ob5 847 3 negative negative JJ cord-006856-b1w25ob5 847 4 rods rod NNS cord-006856-b1w25ob5 847 5 were be VBD cord-006856-b1w25ob5 847 6 cultured culture VBN cord-006856-b1w25ob5 847 7 in in IN cord-006856-b1w25ob5 847 8 twelve twelve CD cord-006856-b1w25ob5 847 9 cases case NNS cord-006856-b1w25ob5 847 10 ( ( -LRB- cord-006856-b1w25ob5 847 11 18 18 CD cord-006856-b1w25ob5 847 12 % % NN cord-006856-b1w25ob5 847 13 ) ) -RRB- cord-006856-b1w25ob5 847 14 . . . cord-006856-b1w25ob5 848 1 Patients patient NNS cord-006856-b1w25ob5 848 2 with with IN cord-006856-b1w25ob5 848 3 blood blood NN cord-006856-b1w25ob5 848 4 borne bear VBN cord-006856-b1w25ob5 848 5 infection infection NN cord-006856-b1w25ob5 848 6 had have VBD cord-006856-b1w25ob5 848 7 a a DT cord-006856-b1w25ob5 848 8 two two CD cord-006856-b1w25ob5 848 9 - - HYPH cord-006856-b1w25ob5 848 10 year year NN cord-006856-b1w25ob5 848 11 pancreas pancreas NN cord-006856-b1w25ob5 848 12 graft graft NN cord-006856-b1w25ob5 848 13 survival survival NN cord-006856-b1w25ob5 848 14 of of IN cord-006856-b1w25ob5 848 15 76.5 76.5 CD cord-006856-b1w25ob5 848 16 % % NN cord-006856-b1w25ob5 848 17 versus versus IN cord-006856-b1w25ob5 848 18 89.4 89.4 CD cord-006856-b1w25ob5 848 19 % % NN cord-006856-b1w25ob5 848 20 for for IN cord-006856-b1w25ob5 848 21 those those DT cord-006856-b1w25ob5 848 22 without without IN cord-006856-b1w25ob5 848 23 sepsis sepsis NN cord-006856-b1w25ob5 848 24 ( ( -LRB- cord-006856-b1w25ob5 848 25 P p NN cord-006856-b1w25ob5 848 26 = = SYM cord-006856-b1w25ob5 848 27 0.036 0.036 CD cord-006856-b1w25ob5 848 28 ) ) -RRB- cord-006856-b1w25ob5 848 29 , , , cord-006856-b1w25ob5 848 30 patient patient JJ cord-006856-b1w25ob5 848 31 survival survival NN cord-006856-b1w25ob5 848 32 was be VBD cord-006856-b1w25ob5 848 33 not not RB cord-006856-b1w25ob5 848 34 affected affect VBN cord-006856-b1w25ob5 848 35 . . . cord-006856-b1w25ob5 849 1 Conclusions conclusion NNS cord-006856-b1w25ob5 849 2 . . . cord-006856-b1w25ob5 850 1 Sepsis sepsis NN cord-006856-b1w25ob5 850 2 remains remain VBZ cord-006856-b1w25ob5 850 3 a a DT cord-006856-b1w25ob5 850 4 serious serious JJ cord-006856-b1w25ob5 850 5 complication complication NN cord-006856-b1w25ob5 850 6 after after IN cord-006856-b1w25ob5 850 7 PTx PTx NNS cord-006856-b1w25ob5 850 8 with with IN cord-006856-b1w25ob5 850 9 significantly significantly RB cord-006856-b1w25ob5 850 10 reduced reduce VBN cord-006856-b1w25ob5 850 11 graft graft NN cord-006856-b1w25ob5 850 12 but but CC cord-006856-b1w25ob5 850 13 not not RB cord-006856-b1w25ob5 850 14 patient patient JJ cord-006856-b1w25ob5 850 15 survival survival NN cord-006856-b1w25ob5 850 16 . . . cord-006856-b1w25ob5 851 1 The the DT cord-006856-b1w25ob5 851 2 most most RBS cord-006856-b1w25ob5 851 3 common common JJ cord-006856-b1w25ob5 851 4 source source NN cord-006856-b1w25ob5 851 5 is be VBZ cord-006856-b1w25ob5 851 6 IAI IAI NNP cord-006856-b1w25ob5 851 7 . . . cord-006856-b1w25ob5 852 1 Background background NN cord-006856-b1w25ob5 852 2 . . . cord-006856-b1w25ob5 853 1 Mobilized mobilize VBN cord-006856-b1w25ob5 853 2 allogeneic allogeneic IN cord-006856-b1w25ob5 853 3 peripheral peripheral JJ cord-006856-b1w25ob5 853 4 blood blood NN cord-006856-b1w25ob5 853 5 stem stem NN cord-006856-b1w25ob5 853 6 cells cell NNS cord-006856-b1w25ob5 853 7 ( ( -LRB- cord-006856-b1w25ob5 853 8 PBSC PBSC NNP cord-006856-b1w25ob5 853 9 ) ) -RRB- cord-006856-b1w25ob5 853 10 are be VBP cord-006856-b1w25ob5 853 11 increasingly increasingly RB cord-006856-b1w25ob5 853 12 used use VBN cord-006856-b1w25ob5 853 13 as as IN cord-006856-b1w25ob5 853 14 graft graft NN cord-006856-b1w25ob5 853 15 source source NN cord-006856-b1w25ob5 853 16 instead instead RB cord-006856-b1w25ob5 853 17 of of IN cord-006856-b1w25ob5 853 18 bone bone NN cord-006856-b1w25ob5 853 19 marrow marrow NN cord-006856-b1w25ob5 853 20 . . . cord-006856-b1w25ob5 854 1 Although although IN cord-006856-b1w25ob5 854 2 the the DT cord-006856-b1w25ob5 854 3 short short JJ cord-006856-b1w25ob5 854 4 - - HYPH cord-006856-b1w25ob5 854 5 term term NN cord-006856-b1w25ob5 854 6 safety safety NN cord-006856-b1w25ob5 854 7 profile profile NN cord-006856-b1w25ob5 854 8 of of IN cord-006856-b1w25ob5 854 9 recombinant recombinant JJ cord-006856-b1w25ob5 854 10 human human JJ cord-006856-b1w25ob5 854 11 granulocyte granulocyte NN cord-006856-b1w25ob5 854 12 colony colony NN cord-006856-b1w25ob5 854 13 - - HYPH cord-006856-b1w25ob5 854 14 stimulated stimulate VBN cord-006856-b1w25ob5 854 15 factor factor NN cord-006856-b1w25ob5 855 1 ( ( -LRB- cord-006856-b1w25ob5 855 2 rhG rhG NNP cord-006856-b1w25ob5 855 3 - - HYPH cord-006856-b1w25ob5 855 4 CSF CSF NNP cord-006856-b1w25ob5 855 5 ) ) -RRB- cord-006856-b1w25ob5 855 6 seems seem VBZ cord-006856-b1w25ob5 855 7 acceptable acceptable JJ cord-006856-b1w25ob5 855 8 , , , cord-006856-b1w25ob5 855 9 minimal minimal JJ cord-006856-b1w25ob5 855 10 data datum NNS cord-006856-b1w25ob5 855 11 exist exist VBP cord-006856-b1w25ob5 855 12 regarding regard VBG cord-006856-b1w25ob5 855 13 long long JJ cord-006856-b1w25ob5 855 14 - - HYPH cord-006856-b1w25ob5 855 15 term term NN cord-006856-b1w25ob5 855 16 safety safety NN cord-006856-b1w25ob5 855 17 . . . cord-006856-b1w25ob5 856 1 Methods method NNS cord-006856-b1w25ob5 856 2 . . . cord-006856-b1w25ob5 857 1 We -PRON- PRP cord-006856-b1w25ob5 857 2 reviewed review VBD cord-006856-b1w25ob5 857 3 data datum NNS cord-006856-b1w25ob5 857 4 of of IN cord-006856-b1w25ob5 857 5 196 196 CD cord-006856-b1w25ob5 857 6 allogeneic allogeneic IN cord-006856-b1w25ob5 857 7 PBSC PBSC NNP cord-006856-b1w25ob5 857 8 donors donor NNS cord-006856-b1w25ob5 857 9 ( ( -LRB- cord-006856-b1w25ob5 857 10 siblings sibling NNS cord-006856-b1w25ob5 857 11 , , , cord-006856-b1w25ob5 857 12 n n NN cord-006856-b1w25ob5 857 13 = = SYM cord-006856-b1w25ob5 857 14 159 159 CD cord-006856-b1w25ob5 857 15 ; ; , cord-006856-b1w25ob5 857 16 unrelated unrelated JJ cord-006856-b1w25ob5 857 17 donors donor NNS cord-006856-b1w25ob5 857 18 , , , cord-006856-b1w25ob5 857 19 n n NN cord-006856-b1w25ob5 857 20 = = SYM cord-006856-b1w25ob5 857 21 37 37 CD cord-006856-b1w25ob5 857 22 ) ) -RRB- cord-006856-b1w25ob5 857 23 with with IN cord-006856-b1w25ob5 857 24 respect respect NN cord-006856-b1w25ob5 857 25 to to IN cord-006856-b1w25ob5 857 26 side side JJ cord-006856-b1w25ob5 857 27 effects effect NNS cord-006856-b1w25ob5 857 28 of of IN cord-006856-b1w25ob5 857 29 rhG rhG NNP cord-006856-b1w25ob5 857 30 - - HYPH cord-006856-b1w25ob5 857 31 CSF csf NN cord-006856-b1w25ob5 857 32 administration administration NN cord-006856-b1w25ob5 857 33 , , , cord-006856-b1w25ob5 857 34 adverse adverse JJ cord-006856-b1w25ob5 857 35 events event NNS cord-006856-b1w25ob5 857 36 of of IN cord-006856-b1w25ob5 857 37 leukapheresis leukapheresis NN cord-006856-b1w25ob5 857 38 and and CC cord-006856-b1w25ob5 857 39 late late JJ cord-006856-b1w25ob5 857 40 effects effect NNS cord-006856-b1w25ob5 857 41 . . . cord-006856-b1w25ob5 858 1 Written write VBN cord-006856-b1w25ob5 858 2 informed informed JJ cord-006856-b1w25ob5 858 3 consent consent NN cord-006856-b1w25ob5 858 4 was be VBD cord-006856-b1w25ob5 858 5 signed sign VBN cord-006856-b1w25ob5 858 6 before before IN cord-006856-b1w25ob5 858 7 PBSC PBSC NNP cord-006856-b1w25ob5 858 8 mobilization mobilization NN cord-006856-b1w25ob5 858 9 and and CC cord-006856-b1w25ob5 858 10 collection collection NN cord-006856-b1w25ob5 858 11 . . . cord-006856-b1w25ob5 859 1 Donors donor NNS cord-006856-b1w25ob5 859 2 ( ( -LRB- cord-006856-b1w25ob5 859 3 M M NNP cord-006856-b1w25ob5 859 4 / / SYM cord-006856-b1w25ob5 859 5 F F NNP cord-006856-b1w25ob5 859 6 , , , cord-006856-b1w25ob5 859 7 119/77 119/77 CD cord-006856-b1w25ob5 859 8 ) ) -RRB- cord-006856-b1w25ob5 859 9 had have VBD cord-006856-b1w25ob5 859 10 a a DT cord-006856-b1w25ob5 859 11 median median JJ cord-006856-b1w25ob5 859 12 age age NN cord-006856-b1w25ob5 859 13 of of IN cord-006856-b1w25ob5 859 14 40 40 CD cord-006856-b1w25ob5 859 15 years year NNS cord-006856-b1w25ob5 859 16 ( ( -LRB- cord-006856-b1w25ob5 859 17 range range NN cord-006856-b1w25ob5 859 18 , , , cord-006856-b1w25ob5 859 19 11 11 CD cord-006856-b1w25ob5 859 20 - - SYM cord-006856-b1w25ob5 859 21 72 72 CD cord-006856-b1w25ob5 859 22 ) ) -RRB- cord-006856-b1w25ob5 859 23 . . . cord-006856-b1w25ob5 860 1 They -PRON- PRP cord-006856-b1w25ob5 860 2 received receive VBD cord-006856-b1w25ob5 860 3 rhG rhG NNP cord-006856-b1w25ob5 860 4 - - HYPH cord-006856-b1w25ob5 860 5 CSF csf NN cord-006856-b1w25ob5 860 6 at at IN cord-006856-b1w25ob5 860 7 a a DT cord-006856-b1w25ob5 860 8 dose dose NN cord-006856-b1w25ob5 860 9 of of IN cord-006856-b1w25ob5 860 10 2 2 CD cord-006856-b1w25ob5 860 11 times time NNS cord-006856-b1w25ob5 860 12 5 5 CD cord-006856-b1w25ob5 860 13 µg µg NN cord-006856-b1w25ob5 860 14 / / SYM cord-006856-b1w25ob5 860 15 kg kg NNS cord-006856-b1w25ob5 860 16 of of IN cord-006856-b1w25ob5 860 17 body body NN cord-006856-b1w25ob5 860 18 weight weight NN cord-006856-b1w25ob5 860 19 a a DT cord-006856-b1w25ob5 860 20 day day NN cord-006856-b1w25ob5 860 21 for for IN cord-006856-b1w25ob5 860 22 4 4 CD cord-006856-b1w25ob5 860 23 consecutive consecutive JJ cord-006856-b1w25ob5 860 24 days day NNS cord-006856-b1w25ob5 860 25 starting start VBG cord-006856-b1w25ob5 860 26 on on IN cord-006856-b1w25ob5 860 27 day day NN cord-006856-b1w25ob5 860 28 1 1 CD cord-006856-b1w25ob5 860 29 . . . cord-006856-b1w25ob5 861 1 Routinely routinely RB cord-006856-b1w25ob5 861 2 , , , cord-006856-b1w25ob5 861 3 PBSC PBSC NNP cord-006856-b1w25ob5 861 4 collection collection NN cord-006856-b1w25ob5 861 5 was be VBD cord-006856-b1w25ob5 861 6 started start VBN cord-006856-b1w25ob5 861 7 on on IN cord-006856-b1w25ob5 861 8 day day NN cord-006856-b1w25ob5 861 9 5 5 CD cord-006856-b1w25ob5 861 10 . . . cord-006856-b1w25ob5 862 1 On on IN cord-006856-b1w25ob5 862 2 condition condition NN cord-006856-b1w25ob5 862 3 that that IN cord-006856-b1w25ob5 862 4 donors donor NNS cord-006856-b1w25ob5 862 5 ' ' POS cord-006856-b1w25ob5 862 6 white white JJ cord-006856-b1w25ob5 862 7 cell cell NN cord-006856-b1w25ob5 862 8 count count NN cord-006856-b1w25ob5 862 9 exceeded exceed VBD cord-006856-b1w25ob5 862 10 70.000/µl 70.000/µl CD cord-006856-b1w25ob5 862 11 or or CC cord-006856-b1w25ob5 862 12 CD34-positive cd34-positive CD cord-006856-b1w25ob5 862 13 cells cell NNS cord-006856-b1w25ob5 862 14 exceeded exceed VBD cord-006856-b1w25ob5 862 15 50/µl 50/µl CD cord-006856-b1w25ob5 862 16 , , , cord-006856-b1w25ob5 862 17 PBSC PBSC NNP cord-006856-b1w25ob5 862 18 harvest harvest NN cord-006856-b1w25ob5 862 19 was be VBD cord-006856-b1w25ob5 862 20 started start VBN cord-006856-b1w25ob5 862 21 on on IN cord-006856-b1w25ob5 862 22 day day NN cord-006856-b1w25ob5 862 23 4 4 CD cord-006856-b1w25ob5 862 24 . . . cord-006856-b1w25ob5 863 1 RhG RhG NNP cord-006856-b1w25ob5 863 2 - - HYPH cord-006856-b1w25ob5 863 3 CSF CSF NNP cord-006856-b1w25ob5 863 4 was be VBD cord-006856-b1w25ob5 863 5 administered administer VBN cord-006856-b1w25ob5 863 6 until until IN cord-006856-b1w25ob5 863 7 end end NN cord-006856-b1w25ob5 863 8 of of IN cord-006856-b1w25ob5 863 9 the the DT cord-006856-b1w25ob5 863 10 apheresis apheresis NN cord-006856-b1w25ob5 863 11 period period NN cord-006856-b1w25ob5 863 12 unless unless IN cord-006856-b1w25ob5 863 13 white white JJ cord-006856-b1w25ob5 863 14 blood blood NN cord-006856-b1w25ob5 863 15 cell cell NN cord-006856-b1w25ob5 863 16 count count NN cord-006856-b1w25ob5 863 17 did do VBD cord-006856-b1w25ob5 863 18 not not RB cord-006856-b1w25ob5 863 19 exceed exceed VB cord-006856-b1w25ob5 863 20 70.000/µl 70.000/µl CD cord-006856-b1w25ob5 863 21 . . . cord-006856-b1w25ob5 864 1 PBSC PBSC NNP cord-006856-b1w25ob5 864 2 were be VBD cord-006856-b1w25ob5 864 3 collected collect VBN cord-006856-b1w25ob5 864 4 with with IN cord-006856-b1w25ob5 864 5 a a DT cord-006856-b1w25ob5 864 6 continuous continuous JJ cord-006856-b1w25ob5 864 7 - - HYPH cord-006856-b1w25ob5 864 8 flow flow NN cord-006856-b1w25ob5 864 9 blood blood NN cord-006856-b1w25ob5 864 10 cell cell NN cord-006856-b1w25ob5 864 11 separator separator NN cord-006856-b1w25ob5 864 12 processing process VBG cord-006856-b1w25ob5 864 13 3 3 CD cord-006856-b1w25ob5 864 14 - - SYM cord-006856-b1w25ob5 864 15 3.5 3.5 CD cord-006856-b1w25ob5 864 16 times time NNS cord-006856-b1w25ob5 864 17 total total JJ cord-006856-b1w25ob5 864 18 blood blood NN cord-006856-b1w25ob5 864 19 volume volume NN cord-006856-b1w25ob5 864 20 . . . cord-006856-b1w25ob5 865 1 Citrate Citrate NNP cord-006856-b1w25ob5 865 2 was be VBD cord-006856-b1w25ob5 865 3 used use VBN cord-006856-b1w25ob5 865 4 as as IN cord-006856-b1w25ob5 865 5 anticoagulation anticoagulation NN cord-006856-b1w25ob5 865 6 and and CC cord-006856-b1w25ob5 865 7 in in IN cord-006856-b1w25ob5 865 8 the the DT cord-006856-b1w25ob5 865 9 majority majority NN cord-006856-b1w25ob5 865 10 of of IN cord-006856-b1w25ob5 865 11 donors donor NNS cord-006856-b1w25ob5 865 12 a a DT cord-006856-b1w25ob5 865 13 continuous continuous JJ cord-006856-b1w25ob5 865 14 calcium calcium NN cord-006856-b1w25ob5 865 15 infusion infusion NN cord-006856-b1w25ob5 865 16 ( ( -LRB- cord-006856-b1w25ob5 865 17 2.25 2.25 CD cord-006856-b1w25ob5 865 18 mmol mmol JJ cord-006856-b1w25ob5 865 19 [ [ -LRB- cord-006856-b1w25ob5 865 20 89.4 89.4 CD cord-006856-b1w25ob5 865 21 mg mg NNS cord-006856-b1w25ob5 865 22 ] ] -RRB- cord-006856-b1w25ob5 865 23 of of IN cord-006856-b1w25ob5 865 24 calcium calcium NN cord-006856-b1w25ob5 865 25 per per IN cord-006856-b1w25ob5 865 26 h h NN cord-006856-b1w25ob5 865 27 ) ) -RRB- cord-006856-b1w25ob5 865 28 was be VBD cord-006856-b1w25ob5 865 29 given give VBN cord-006856-b1w25ob5 865 30 . . . cord-006856-b1w25ob5 866 1 Reinfusion reinfusion NN cord-006856-b1w25ob5 866 2 of of IN cord-006856-b1w25ob5 866 3 autologous autologous JJ cord-006856-b1w25ob5 866 4 platelet platelet NN cord-006856-b1w25ob5 866 5 - - HYPH cord-006856-b1w25ob5 866 6 rich rich JJ cord-006856-b1w25ob5 866 7 plasma plasma NN cord-006856-b1w25ob5 866 8 from from IN cord-006856-b1w25ob5 866 9 PBSC PBSC NNP cord-006856-b1w25ob5 866 10 collection collection NN cord-006856-b1w25ob5 866 11 was be VBD cord-006856-b1w25ob5 866 12 performed perform VBN cord-006856-b1w25ob5 866 13 in in IN cord-006856-b1w25ob5 866 14 donors donor NNS cord-006856-b1w25ob5 866 15 with with IN cord-006856-b1w25ob5 866 16 post post JJ cord-006856-b1w25ob5 866 17 - - JJ cord-006856-b1w25ob5 866 18 donation donation JJ cord-006856-b1w25ob5 866 19 thrombocytopenia thrombocytopenia NN cord-006856-b1w25ob5 866 20 of of IN cord-006856-b1w25ob5 866 21 < < $ cord-006856-b1w25ob5 866 22 100 100 CD cord-006856-b1w25ob5 866 23 G g NN cord-006856-b1w25ob5 866 24 / / SYM cord-006856-b1w25ob5 866 25 liter liter NN cord-006856-b1w25ob5 866 26 if if IN cord-006856-b1w25ob5 866 27 further further JJ cord-006856-b1w25ob5 866 28 collection collection NN cord-006856-b1w25ob5 866 29 were be VBD cord-006856-b1w25ob5 866 30 necessary necessary JJ cord-006856-b1w25ob5 866 31 or or CC cord-006856-b1w25ob5 866 32 in in IN cord-006856-b1w25ob5 866 33 donors donor NNS cord-006856-b1w25ob5 866 34 with with IN cord-006856-b1w25ob5 866 35 platelet platelet NN cord-006856-b1w25ob5 866 36 counts count NNS cord-006856-b1w25ob5 866 37 of of IN cord-006856-b1w25ob5 866 38 < < $ cord-006856-b1w25ob5 866 39 80 80 CD cord-006856-b1w25ob5 866 40 G g NN cord-006856-b1w25ob5 866 41 / / SYM cord-006856-b1w25ob5 866 42 liter liter NN cord-006856-b1w25ob5 866 43 , , , cord-006856-b1w25ob5 866 44 respectively respectively RB cord-006856-b1w25ob5 866 45 . . . cord-006856-b1w25ob5 867 1 PBSC PBSC NNP cord-006856-b1w25ob5 867 2 harvest harvest NN cord-006856-b1w25ob5 867 3 procedures procedure NNS cord-006856-b1w25ob5 867 4 were be VBD cord-006856-b1w25ob5 867 5 repeated repeat VBN cord-006856-b1w25ob5 867 6 until until IN cord-006856-b1w25ob5 867 7 the the DT cord-006856-b1w25ob5 867 8 predicted predict VBN cord-006856-b1w25ob5 867 9 CD34 CD34 NNP cord-006856-b1w25ob5 867 10 + + CC cord-006856-b1w25ob5 867 11 cell cell NN cord-006856-b1w25ob5 867 12 yield yield NN cord-006856-b1w25ob5 867 13 of of IN cord-006856-b1w25ob5 867 14 4 4 CD cord-006856-b1w25ob5 867 15 × × NN cord-006856-b1w25ob5 867 16 10 10 CD cord-006856-b1w25ob5 867 17 6 6 CD cord-006856-b1w25ob5 867 18 /kg /kg CD cord-006856-b1w25ob5 867 19 of of IN cord-006856-b1w25ob5 867 20 body body NN cord-006856-b1w25ob5 867 21 weight weight NN cord-006856-b1w25ob5 867 22 of of IN cord-006856-b1w25ob5 867 23 recipient recipient NN cord-006856-b1w25ob5 867 24 was be VBD cord-006856-b1w25ob5 867 25 collected collect VBN cord-006856-b1w25ob5 867 26 . . . cord-006856-b1w25ob5 868 1 However however RB cord-006856-b1w25ob5 868 2 , , , cord-006856-b1w25ob5 868 3 not not RB cord-006856-b1w25ob5 868 4 more more JJR cord-006856-b1w25ob5 868 5 than than IN cord-006856-b1w25ob5 868 6 3 3 CD cord-006856-b1w25ob5 868 7 consecutive consecutive JJ cord-006856-b1w25ob5 868 8 collections collection NNS cord-006856-b1w25ob5 868 9 were be VBD cord-006856-b1w25ob5 868 10 performed perform VBN cord-006856-b1w25ob5 868 11 . . . cord-006856-b1w25ob5 869 1 Flowcytometric flowcytometric NN cord-006856-b1w25ob5 869 2 analyses analysis NNS cord-006856-b1w25ob5 869 3 were be VBD cord-006856-b1w25ob5 869 4 performed perform VBN cord-006856-b1w25ob5 869 5 using use VBG cord-006856-b1w25ob5 869 6 a a DT cord-006856-b1w25ob5 869 7 Becton Becton NNP cord-006856-b1w25ob5 869 8 - - HYPH cord-006856-b1w25ob5 869 9 Dickinson Dickinson NNP cord-006856-b1w25ob5 869 10 FACS FACS NNP cord-006856-b1w25ob5 869 11 - - HYPH cord-006856-b1w25ob5 869 12 Scan Scan NNP cord-006856-b1w25ob5 869 13 or or CC cord-006856-b1w25ob5 869 14 FACS FACS NNP cord-006856-b1w25ob5 869 15 - - HYPH cord-006856-b1w25ob5 869 16 Calibur Calibur NNP cord-006856-b1w25ob5 869 17 , , , cord-006856-b1w25ob5 869 18 respectively respectively RB cord-006856-b1w25ob5 869 19 . . . cord-006856-b1w25ob5 870 1 For for IN cord-006856-b1w25ob5 870 2 follow follow NN cord-006856-b1w25ob5 870 3 - - HYPH cord-006856-b1w25ob5 870 4 up up NN cord-006856-b1w25ob5 870 5 we -PRON- PRP cord-006856-b1w25ob5 870 6 assessed assess VBD cord-006856-b1w25ob5 870 7 peripheral peripheral JJ cord-006856-b1w25ob5 870 8 blood blood NN cord-006856-b1w25ob5 870 9 counts count NNS cord-006856-b1w25ob5 870 10 , , , cord-006856-b1w25ob5 870 11 electrolytes electrolyte NNS cord-006856-b1w25ob5 870 12 , , , cord-006856-b1w25ob5 870 13 lactic lactic JJ cord-006856-b1w25ob5 870 14 dehydrogenase dehydrogenase NN cord-006856-b1w25ob5 870 15 ( ( -LRB- cord-006856-b1w25ob5 870 16 LDH LDH NNP cord-006856-b1w25ob5 870 17 ) ) -RRB- cord-006856-b1w25ob5 870 18 , , , cord-006856-b1w25ob5 870 19 alkaline alkaline JJ cord-006856-b1w25ob5 870 20 phosphatase phosphatase NN cord-006856-b1w25ob5 870 21 ( ( -LRB- cord-006856-b1w25ob5 870 22 AP AP NNP cord-006856-b1w25ob5 870 23 ) ) -RRB- cord-006856-b1w25ob5 870 24 , , , cord-006856-b1w25ob5 870 25 total total JJ cord-006856-b1w25ob5 870 26 protein protein NN cord-006856-b1w25ob5 870 27 , , , cord-006856-b1w25ob5 870 28 albumin albumin NN cord-006856-b1w25ob5 870 29 , , , cord-006856-b1w25ob5 870 30 on on IN cord-006856-b1w25ob5 870 31 days day NNS cord-006856-b1w25ob5 870 32 1 1 CD cord-006856-b1w25ob5 870 33 , , , cord-006856-b1w25ob5 870 34 7 7 CD cord-006856-b1w25ob5 870 35 , , , cord-006856-b1w25ob5 870 36 30 30 CD cord-006856-b1w25ob5 870 37 , , , cord-006856-b1w25ob5 870 38 100 100 CD cord-006856-b1w25ob5 870 39 , , , cord-006856-b1w25ob5 870 40 365 365 CD cord-006856-b1w25ob5 870 41 and and CC cord-006856-b1w25ob5 870 42 then then RB cord-006856-b1w25ob5 870 43 yearly yearly JJ cord-006856-b1w25ob5 870 44 for for IN cord-006856-b1w25ob5 870 45 5 5 CD cord-006856-b1w25ob5 870 46 years year NNS cord-006856-b1w25ob5 870 47 . . . cord-006856-b1w25ob5 871 1 Donors donor NNS cord-006856-b1w25ob5 871 2 received receive VBD cord-006856-b1w25ob5 871 3 a a DT cord-006856-b1w25ob5 871 4 questionnaire questionnaire NN cord-006856-b1w25ob5 871 5 for for IN cord-006856-b1w25ob5 871 6 evaluation evaluation NN cord-006856-b1w25ob5 871 7 of of IN cord-006856-b1w25ob5 871 8 medical medical JJ cord-006856-b1w25ob5 871 9 history history NN cord-006856-b1w25ob5 871 10 and and CC cord-006856-b1w25ob5 871 11 quality quality NN cord-006856-b1w25ob5 871 12 of of IN cord-006856-b1w25ob5 871 13 life life NN cord-006856-b1w25ob5 871 14 , , , cord-006856-b1w25ob5 871 15 results result NNS cord-006856-b1w25ob5 871 16 and and CC cord-006856-b1w25ob5 871 17 evaluation evaluation NN cord-006856-b1w25ob5 871 18 are be VBP cord-006856-b1w25ob5 871 19 pending pende VBG cord-006856-b1w25ob5 871 20 . . . cord-006856-b1w25ob5 872 1 Results result NNS cord-006856-b1w25ob5 872 2 . . . cord-006856-b1w25ob5 873 1 The the DT cord-006856-b1w25ob5 873 2 main main JJ cord-006856-b1w25ob5 873 3 adverse adverse JJ cord-006856-b1w25ob5 873 4 events event NNS cord-006856-b1w25ob5 873 5 related relate VBN cord-006856-b1w25ob5 873 6 to to IN cord-006856-b1w25ob5 873 7 rhG rhG NNP cord-006856-b1w25ob5 873 8 - - HYPH cord-006856-b1w25ob5 873 9 CSF CSF NNP cord-006856-b1w25ob5 873 10 administration administration NN cord-006856-b1w25ob5 873 11 were be VBD cord-006856-b1w25ob5 873 12 bone bone NN cord-006856-b1w25ob5 873 13 pain pain NN cord-006856-b1w25ob5 873 14 ( ( -LRB- cord-006856-b1w25ob5 873 15 63 63 CD cord-006856-b1w25ob5 873 16 of of IN cord-006856-b1w25ob5 873 17 196 196 CD cord-006856-b1w25ob5 873 18 , , , cord-006856-b1w25ob5 873 19 32 32 CD cord-006856-b1w25ob5 873 20 % % NN cord-006856-b1w25ob5 873 21 ) ) -RRB- cord-006856-b1w25ob5 873 22 , , , cord-006856-b1w25ob5 873 23 myalgia myalgia NN cord-006856-b1w25ob5 873 24 ( ( -LRB- cord-006856-b1w25ob5 873 25 61 61 CD cord-006856-b1w25ob5 873 26 of of IN cord-006856-b1w25ob5 873 27 196 196 CD cord-006856-b1w25ob5 873 28 , , , cord-006856-b1w25ob5 873 29 31 31 CD cord-006856-b1w25ob5 873 30 % % NN cord-006856-b1w25ob5 873 31 ) ) -RRB- cord-006856-b1w25ob5 873 32 , , , cord-006856-b1w25ob5 873 33 headache headache NN cord-006856-b1w25ob5 873 34 ( ( -LRB- cord-006856-b1w25ob5 873 35 44 44 CD cord-006856-b1w25ob5 873 36 of of IN cord-006856-b1w25ob5 873 37 196 196 CD cord-006856-b1w25ob5 873 38 , , , cord-006856-b1w25ob5 873 39 22 22 CD cord-006856-b1w25ob5 873 40 % % NN cord-006856-b1w25ob5 873 41 ) ) -RRB- cord-006856-b1w25ob5 873 42 , , , cord-006856-b1w25ob5 873 43 fatigue fatigue NN cord-006856-b1w25ob5 873 44 ( ( -LRB- cord-006856-b1w25ob5 873 45 36 36 CD cord-006856-b1w25ob5 873 46 of of IN cord-006856-b1w25ob5 873 47 196 196 CD cord-006856-b1w25ob5 873 48 , , , cord-006856-b1w25ob5 873 49 18 18 CD cord-006856-b1w25ob5 873 50 % % NN cord-006856-b1w25ob5 873 51 ) ) -RRB- cord-006856-b1w25ob5 873 52 , , , cord-006856-b1w25ob5 873 53 sleep sleep NN cord-006856-b1w25ob5 873 54 disturbance disturbance NN cord-006856-b1w25ob5 873 55 ( ( -LRB- cord-006856-b1w25ob5 873 56 30 30 CD cord-006856-b1w25ob5 873 57 of of IN cord-006856-b1w25ob5 873 58 196 196 CD cord-006856-b1w25ob5 873 59 , , , cord-006856-b1w25ob5 873 60 15 15 CD cord-006856-b1w25ob5 873 61 % % NN cord-006856-b1w25ob5 873 62 ) ) -RRB- cord-006856-b1w25ob5 873 63 and and CC cord-006856-b1w25ob5 873 64 were be VBD cord-006856-b1w25ob5 873 65 rated rate VBN cord-006856-b1w25ob5 873 66 as as IN cord-006856-b1w25ob5 873 67 moderate moderate JJ cord-006856-b1w25ob5 873 68 to to IN cord-006856-b1w25ob5 873 69 severe severe JJ cord-006856-b1w25ob5 873 70 by by IN cord-006856-b1w25ob5 873 71 35 35 CD cord-006856-b1w25ob5 873 72 % % NN cord-006856-b1w25ob5 873 73 of of IN cord-006856-b1w25ob5 873 74 the the DT cord-006856-b1w25ob5 873 75 donors donor NNS cord-006856-b1w25ob5 873 76 . . . cord-006856-b1w25ob5 874 1 Due due IN cord-006856-b1w25ob5 874 2 to to IN cord-006856-b1w25ob5 874 3 continuous continuous JJ cord-006856-b1w25ob5 874 4 calcium calcium NN cord-006856-b1w25ob5 874 5 infusion infusion NN cord-006856-b1w25ob5 874 6 , , , cord-006856-b1w25ob5 874 7 incidence incidence NN cord-006856-b1w25ob5 874 8 of of IN cord-006856-b1w25ob5 874 9 citrate citrate NN cord-006856-b1w25ob5 874 10 toxcicity toxcicity NN cord-006856-b1w25ob5 874 11 was be VBD cord-006856-b1w25ob5 874 12 low low JJ cord-006856-b1w25ob5 874 13 ( ( -LRB- cord-006856-b1w25ob5 874 14 34 34 CD cord-006856-b1w25ob5 874 15 of of IN cord-006856-b1w25ob5 874 16 196 196 CD cord-006856-b1w25ob5 874 17 , , , cord-006856-b1w25ob5 874 18 17 17 CD cord-006856-b1w25ob5 874 19 % % NN cord-006856-b1w25ob5 874 20 ) ) -RRB- cord-006856-b1w25ob5 874 21 and and CC cord-006856-b1w25ob5 874 22 consisted consist VBD cord-006856-b1w25ob5 874 23 only only RB cord-006856-b1w25ob5 874 24 of of IN cord-006856-b1w25ob5 874 25 mild mild JJ cord-006856-b1w25ob5 874 26 paraesthesia paraesthesia NNS cord-006856-b1w25ob5 874 27 . . . cord-006856-b1w25ob5 875 1 In in IN cord-006856-b1w25ob5 875 2 10 10 CD cord-006856-b1w25ob5 875 3 of of IN cord-006856-b1w25ob5 875 4 196 196 CD cord-006856-b1w25ob5 875 5 ( ( -LRB- cord-006856-b1w25ob5 875 6 5 5 CD cord-006856-b1w25ob5 875 7 % % NN cord-006856-b1w25ob5 875 8 ) ) -RRB- cord-006856-b1w25ob5 876 1 donors donor NNS cord-006856-b1w25ob5 876 2 post post VBP cord-006856-b1w25ob5 877 1 donation donation NN cord-006856-b1w25ob5 877 2 platelet platelet NN cord-006856-b1w25ob5 877 3 count count NN cord-006856-b1w25ob5 877 4 decreased decrease VBD cord-006856-b1w25ob5 877 5 below below IN cord-006856-b1w25ob5 877 6 threshold threshold NN cord-006856-b1w25ob5 877 7 and and CC cord-006856-b1w25ob5 877 8 required require VBN cord-006856-b1w25ob5 877 9 reinfusion reinfusion NN cord-006856-b1w25ob5 877 10 of of IN cord-006856-b1w25ob5 877 11 autologous autologous JJ cord-006856-b1w25ob5 877 12 rich rich JJ cord-006856-b1w25ob5 877 13 plasma plasma NN cord-006856-b1w25ob5 877 14 . . . cord-006856-b1w25ob5 878 1 Eighty eighty CD cord-006856-b1w25ob5 878 2 - - HYPH cord-006856-b1w25ob5 878 3 eight eight CD cord-006856-b1w25ob5 878 4 of of IN cord-006856-b1w25ob5 878 5 196 196 CD cord-006856-b1w25ob5 878 6 donors donor NNS cord-006856-b1w25ob5 878 7 ( ( -LRB- cord-006856-b1w25ob5 878 8 44 44 CD cord-006856-b1w25ob5 878 9 % % NN cord-006856-b1w25ob5 878 10 ) ) -RRB- cord-006856-b1w25ob5 878 11 were be VBD cord-006856-b1w25ob5 878 12 lost lose VBN cord-006856-b1w25ob5 878 13 for for IN cord-006856-b1w25ob5 878 14 follow follow NN cord-006856-b1w25ob5 878 15 - - HYPH cord-006856-b1w25ob5 878 16 up up NN cord-006856-b1w25ob5 878 17 . . . cord-006856-b1w25ob5 879 1 Eighty eighty CD cord-006856-b1w25ob5 879 2 - - HYPH cord-006856-b1w25ob5 879 3 two two CD cord-006856-b1w25ob5 879 4 were be VBD cord-006856-b1w25ob5 879 5 sibling sible VBG cord-006856-b1w25ob5 879 6 ( ( -LRB- cord-006856-b1w25ob5 879 7 82 82 CD cord-006856-b1w25ob5 879 8 of of IN cord-006856-b1w25ob5 879 9 159 159 CD cord-006856-b1w25ob5 879 10 , , , cord-006856-b1w25ob5 879 11 52 52 CD cord-006856-b1w25ob5 879 12 % % NN cord-006856-b1w25ob5 879 13 ) ) -RRB- cord-006856-b1w25ob5 879 14 and and CC cord-006856-b1w25ob5 879 15 6 6 CD cord-006856-b1w25ob5 879 16 ( ( -LRB- cord-006856-b1w25ob5 879 17 6 6 CD cord-006856-b1w25ob5 879 18 of of IN cord-006856-b1w25ob5 879 19 37 37 CD cord-006856-b1w25ob5 879 20 , , , cord-006856-b1w25ob5 879 21 16 16 CD cord-006856-b1w25ob5 879 22 % % NN cord-006856-b1w25ob5 879 23 ) ) -RRB- cord-006856-b1w25ob5 879 24 were be VBD cord-006856-b1w25ob5 879 25 matched match VBN cord-006856-b1w25ob5 879 26 unrelated unrelated JJ cord-006856-b1w25ob5 879 27 donors donor NNS cord-006856-b1w25ob5 879 28 , , , cord-006856-b1w25ob5 879 29 respectively respectively RB cord-006856-b1w25ob5 879 30 . . . cord-006856-b1w25ob5 880 1 From from IN cord-006856-b1w25ob5 880 2 the the DT cord-006856-b1w25ob5 880 3 remaining remain VBG cord-006856-b1w25ob5 880 4 108 108 CD cord-006856-b1w25ob5 880 5 donors donor NNS cord-006856-b1w25ob5 880 6 , , , cord-006856-b1w25ob5 880 7 unrelated unrelated JJ cord-006856-b1w25ob5 880 8 donors donor NNS cord-006856-b1w25ob5 880 9 ( ( -LRB- cord-006856-b1w25ob5 880 10 31 31 CD cord-006856-b1w25ob5 880 11 of of IN cord-006856-b1w25ob5 880 12 37 37 CD cord-006856-b1w25ob5 880 13 , , , cord-006856-b1w25ob5 880 14 84 84 CD cord-006856-b1w25ob5 880 15 % % NN cord-006856-b1w25ob5 880 16 ) ) -RRB- cord-006856-b1w25ob5 880 17 had have VBD cord-006856-b1w25ob5 880 18 a a DT cord-006856-b1w25ob5 880 19 median median NN cord-006856-b1w25ob5 880 20 of of IN cord-006856-b1w25ob5 880 21 4 4 CD cord-006856-b1w25ob5 880 22 check check NN cord-006856-b1w25ob5 880 23 - - HYPH cord-006856-b1w25ob5 880 24 ups up NNS cord-006856-b1w25ob5 880 25 ( ( -LRB- cord-006856-b1w25ob5 880 26 range range NN cord-006856-b1w25ob5 880 27 , , , cord-006856-b1w25ob5 880 28 1 1 CD cord-006856-b1w25ob5 880 29 - - SYM cord-006856-b1w25ob5 880 30 8 8 CD cord-006856-b1w25ob5 880 31 ) ) -RRB- cord-006856-b1w25ob5 880 32 during during IN cord-006856-b1w25ob5 880 33 the the DT cord-006856-b1w25ob5 880 34 first first JJ cord-006856-b1w25ob5 880 35 100 100 CD cord-006856-b1w25ob5 880 36 days day NNS cord-006856-b1w25ob5 880 37 ( ( -LRB- cord-006856-b1w25ob5 880 38 median median NN cord-006856-b1w25ob5 880 39 ; ; : cord-006856-b1w25ob5 880 40 range range NN cord-006856-b1w25ob5 880 41 , , , cord-006856-b1w25ob5 880 42 1 1 CD cord-006856-b1w25ob5 880 43 day day NN cord-006856-b1w25ob5 880 44 to to IN cord-006856-b1w25ob5 880 45 3 3 CD cord-006856-b1w25ob5 880 46 years year NNS cord-006856-b1w25ob5 880 47 ) ) -RRB- cord-006856-b1w25ob5 880 48 after after IN cord-006856-b1w25ob5 880 49 donation donation NN cord-006856-b1w25ob5 880 50 , , , cord-006856-b1w25ob5 880 51 whereas whereas IN cord-006856-b1w25ob5 880 52 siblings sibling NNS cord-006856-b1w25ob5 880 53 ( ( -LRB- cord-006856-b1w25ob5 880 54 77 77 CD cord-006856-b1w25ob5 880 55 of of IN cord-006856-b1w25ob5 880 56 159 159 CD cord-006856-b1w25ob5 880 57 , , , cord-006856-b1w25ob5 880 58 48 48 CD cord-006856-b1w25ob5 880 59 % % NN cord-006856-b1w25ob5 880 60 ) ) -RRB- cord-006856-b1w25ob5 880 61 had have VBD cord-006856-b1w25ob5 880 62 a a DT cord-006856-b1w25ob5 880 63 median median NN cord-006856-b1w25ob5 880 64 of of IN cord-006856-b1w25ob5 880 65 2 2 CD cord-006856-b1w25ob5 880 66 check check NN cord-006856-b1w25ob5 880 67 - - HYPH cord-006856-b1w25ob5 880 68 ups up NNS cord-006856-b1w25ob5 880 69 ( ( -LRB- cord-006856-b1w25ob5 880 70 range range NN cord-006856-b1w25ob5 880 71 , , , cord-006856-b1w25ob5 880 72 1 1 CD cord-006856-b1w25ob5 880 73 - - SYM cord-006856-b1w25ob5 880 74 6 6 CD cord-006856-b1w25ob5 880 75 ) ) -RRB- cord-006856-b1w25ob5 880 76 during during IN cord-006856-b1w25ob5 880 77 the the DT cord-006856-b1w25ob5 880 78 first first JJ cord-006856-b1w25ob5 880 79 30 30 CD cord-006856-b1w25ob5 880 80 days day NNS cord-006856-b1w25ob5 880 81 ( ( -LRB- cord-006856-b1w25ob5 880 82 median median NN cord-006856-b1w25ob5 880 83 ; ; : cord-006856-b1w25ob5 880 84 range range NN cord-006856-b1w25ob5 880 85 , , , cord-006856-b1w25ob5 880 86 1 1 CD cord-006856-b1w25ob5 880 87 day day NN cord-006856-b1w25ob5 880 88 to to IN cord-006856-b1w25ob5 880 89 5 5 CD cord-006856-b1w25ob5 880 90 years year NNS cord-006856-b1w25ob5 880 91 ) ) -RRB- cord-006856-b1w25ob5 880 92 , , , cord-006856-b1w25ob5 880 93 respectively respectively RB cord-006856-b1w25ob5 880 94 . . . cord-006856-b1w25ob5 881 1 Two two CD cord-006856-b1w25ob5 881 2 donors donor NNS cord-006856-b1w25ob5 881 3 ( ( -LRB- cord-006856-b1w25ob5 881 4 1 1 CD cord-006856-b1w25ob5 881 5 % % NN cord-006856-b1w25ob5 881 6 ) ) -RRB- cord-006856-b1w25ob5 881 7 , , , cord-006856-b1w25ob5 881 8 both both DT cord-006856-b1w25ob5 881 9 siblings sibling NNS cord-006856-b1w25ob5 881 10 , , , cord-006856-b1w25ob5 881 11 were be VBD cord-006856-b1w25ob5 881 12 hospitalized hospitalize VBN cord-006856-b1w25ob5 881 13 within within IN cord-006856-b1w25ob5 881 14 2 2 CD cord-006856-b1w25ob5 881 15 weeks week NNS cord-006856-b1w25ob5 881 16 after after IN cord-006856-b1w25ob5 881 17 donation donation NN cord-006856-b1w25ob5 881 18 due due JJ cord-006856-b1w25ob5 881 19 to to IN cord-006856-b1w25ob5 881 20 severe severe JJ cord-006856-b1w25ob5 881 21 enteritis enteritis NN cord-006856-b1w25ob5 881 22 and and CC cord-006856-b1w25ob5 881 23 subarachnoidal subarachnoidal JJ cord-006856-b1w25ob5 881 24 haemorrhage haemorrhage NN cord-006856-b1w25ob5 881 25 . . . cord-006856-b1w25ob5 882 1 The the DT cord-006856-b1w25ob5 882 2 latter latter JJ cord-006856-b1w25ob5 882 3 donor donor NN cord-006856-b1w25ob5 882 4 never never RB cord-006856-b1w25ob5 882 5 had have VBD cord-006856-b1w25ob5 882 6 platelet platelet NN cord-006856-b1w25ob5 882 7 counts count NNS cord-006856-b1w25ob5 882 8 below below IN cord-006856-b1w25ob5 882 9 100 100 CD cord-006856-b1w25ob5 882 10 G g NN cord-006856-b1w25ob5 882 11 / / SYM cord-006856-b1w25ob5 882 12 liter liter NN cord-006856-b1w25ob5 882 13 after after IN cord-006856-b1w25ob5 882 14 PBSC PBSC NNP cord-006856-b1w25ob5 882 15 donation donation NN cord-006856-b1w25ob5 882 16 and and CC cord-006856-b1w25ob5 882 17 recovered recover VBD cord-006856-b1w25ob5 882 18 without without IN cord-006856-b1w25ob5 882 19 neurological neurological JJ cord-006856-b1w25ob5 882 20 deficit deficit NN cord-006856-b1w25ob5 882 21 . . . cord-006856-b1w25ob5 883 1 Follow follow VB cord-006856-b1w25ob5 883 2 - - HYPH cord-006856-b1w25ob5 883 3 up up NN cord-006856-b1w25ob5 883 4 of of IN cord-006856-b1w25ob5 883 5 peripheral peripheral JJ cord-006856-b1w25ob5 883 6 blood blood NN cord-006856-b1w25ob5 883 7 counts count NNS cord-006856-b1w25ob5 883 8 showed show VBD cord-006856-b1w25ob5 883 9 a a DT cord-006856-b1w25ob5 883 10 loss loss NN cord-006856-b1w25ob5 883 11 of of IN cord-006856-b1w25ob5 883 12 platelets platelet NNS cord-006856-b1w25ob5 883 13 during during IN cord-006856-b1w25ob5 883 14 donation donation NN cord-006856-b1w25ob5 883 15 and and CC cord-006856-b1w25ob5 883 16 early early JJ cord-006856-b1w25ob5 883 17 post post JJ cord-006856-b1w25ob5 883 18 - - JJ cord-006856-b1w25ob5 883 19 donation donation JJ cord-006856-b1w25ob5 883 20 period period NN cord-006856-b1w25ob5 883 21 and and CC cord-006856-b1w25ob5 883 22 a a DT cord-006856-b1w25ob5 883 23 decrease decrease NN cord-006856-b1w25ob5 883 24 of of IN cord-006856-b1w25ob5 883 25 white white JJ cord-006856-b1w25ob5 883 26 blood blood NN cord-006856-b1w25ob5 883 27 cells cell NNS cord-006856-b1w25ob5 883 28 7 7 CD cord-006856-b1w25ob5 883 29 days day NNS cord-006856-b1w25ob5 883 30 after after IN cord-006856-b1w25ob5 883 31 donation donation NN cord-006856-b1w25ob5 883 32 , , , cord-006856-b1w25ob5 883 33 both both DT cord-006856-b1w25ob5 883 34 returning return VBG cord-006856-b1w25ob5 883 35 to to IN cord-006856-b1w25ob5 883 36 normal normal JJ cord-006856-b1w25ob5 883 37 within within IN cord-006856-b1w25ob5 883 38 30 30 CD cord-006856-b1w25ob5 883 39 days day NNS cord-006856-b1w25ob5 883 40 after after RB cord-006856-b1w25ob5 883 41 , , , cord-006856-b1w25ob5 883 42 respectively respectively RB cord-006856-b1w25ob5 883 43 . . . cord-006856-b1w25ob5 884 1 LDH LDH NNP cord-006856-b1w25ob5 884 2 and and CC cord-006856-b1w25ob5 884 3 AP AP NNP cord-006856-b1w25ob5 884 4 showed show VBD cord-006856-b1w25ob5 884 5 a a DT cord-006856-b1w25ob5 884 6 significant significant JJ cord-006856-b1w25ob5 884 7 increase increase NN cord-006856-b1w25ob5 884 8 during during IN cord-006856-b1w25ob5 884 9 PBSC PBSC NNP cord-006856-b1w25ob5 884 10 mobilization mobilization NN cord-006856-b1w25ob5 884 11 , , , cord-006856-b1w25ob5 884 12 they -PRON- PRP cord-006856-b1w25ob5 884 13 returned return VBD cord-006856-b1w25ob5 884 14 to to IN cord-006856-b1w25ob5 884 15 normal normal JJ cord-006856-b1w25ob5 884 16 within within IN cord-006856-b1w25ob5 884 17 1 1 CD cord-006856-b1w25ob5 884 18 week week NN cord-006856-b1w25ob5 884 19 after after IN cord-006856-b1w25ob5 884 20 donation donation NN cord-006856-b1w25ob5 884 21 , , , cord-006856-b1w25ob5 884 22 other other JJ cord-006856-b1w25ob5 884 23 blood blood NN cord-006856-b1w25ob5 884 24 parameters parameter NNS cord-006856-b1w25ob5 884 25 remained remain VBD cord-006856-b1w25ob5 884 26 unaffected unaffected JJ cord-006856-b1w25ob5 884 27 . . . cord-006856-b1w25ob5 885 1 Conclusions conclusion NNS cord-006856-b1w25ob5 885 2 . . . cord-006856-b1w25ob5 886 1 Due due IN cord-006856-b1w25ob5 886 2 to to IN cord-006856-b1w25ob5 886 3 the the DT cord-006856-b1w25ob5 886 4 fact fact NN cord-006856-b1w25ob5 886 5 that that IN cord-006856-b1w25ob5 886 6 we -PRON- PRP cord-006856-b1w25ob5 886 7 observed observe VBD cord-006856-b1w25ob5 886 8 hospitalization hospitalization NN cord-006856-b1w25ob5 886 9 of of IN cord-006856-b1w25ob5 886 10 2 2 CD cord-006856-b1w25ob5 886 11 donors donor NNS cord-006856-b1w25ob5 886 12 within within IN cord-006856-b1w25ob5 886 13 14 14 CD cord-006856-b1w25ob5 886 14 days day NNS cord-006856-b1w25ob5 886 15 after after IN cord-006856-b1w25ob5 886 16 PBSC PBSC NNP cord-006856-b1w25ob5 886 17 collection collection NN cord-006856-b1w25ob5 886 18 , , , cord-006856-b1w25ob5 886 19 a a DT cord-006856-b1w25ob5 886 20 close close JJ cord-006856-b1w25ob5 886 21 monitoring monitoring NN cord-006856-b1w25ob5 886 22 of of IN cord-006856-b1w25ob5 886 23 donors donor NNS cord-006856-b1w25ob5 886 24 in in IN cord-006856-b1w25ob5 886 25 the the DT cord-006856-b1w25ob5 886 26 early early JJ cord-006856-b1w25ob5 886 27 post post JJ cord-006856-b1w25ob5 886 28 - - JJ cord-006856-b1w25ob5 886 29 donation donation JJ cord-006856-b1w25ob5 886 30 period period NN cord-006856-b1w25ob5 886 31 seems seem VBZ cord-006856-b1w25ob5 886 32 advisable advisable JJ cord-006856-b1w25ob5 886 33 . . . cord-006856-b1w25ob5 887 1 Although although IN cord-006856-b1w25ob5 887 2 reported report VBN cord-006856-b1w25ob5 887 3 anomalies anomaly NNS cord-006856-b1w25ob5 887 4 in in IN cord-006856-b1w25ob5 887 5 medical medical JJ cord-006856-b1w25ob5 887 6 history history NN cord-006856-b1w25ob5 887 7 of of IN cord-006856-b1w25ob5 887 8 donors donor NNS cord-006856-b1w25ob5 887 9 beyond beyond IN cord-006856-b1w25ob5 887 10 30 30 CD cord-006856-b1w25ob5 887 11 days day NNS cord-006856-b1w25ob5 887 12 after after IN cord-006856-b1w25ob5 887 13 PBSC PBSC NNP cord-006856-b1w25ob5 887 14 harvest harvest NN cord-006856-b1w25ob5 887 15 could could MD cord-006856-b1w25ob5 887 16 not not RB cord-006856-b1w25ob5 887 17 be be VB cord-006856-b1w25ob5 887 18 associated associate VBN cord-006856-b1w25ob5 887 19 with with IN cord-006856-b1w25ob5 887 20 rhG rhG NNP cord-006856-b1w25ob5 887 21 - - HYPH cord-006856-b1w25ob5 887 22 CSF CSF NNP cord-006856-b1w25ob5 887 23 administration administration NN cord-006856-b1w25ob5 887 24 , , , cord-006856-b1w25ob5 887 25 a a DT cord-006856-b1w25ob5 887 26 regular regular JJ cord-006856-b1w25ob5 887 27 followup followup NN cord-006856-b1w25ob5 887 28 for for IN cord-006856-b1w25ob5 887 29 at at RB cord-006856-b1w25ob5 887 30 least least JJS cord-006856-b1w25ob5 887 31 5 5 CD cord-006856-b1w25ob5 887 32 years year NNS cord-006856-b1w25ob5 887 33 should should MD cord-006856-b1w25ob5 887 34 be be VB cord-006856-b1w25ob5 887 35 considered consider VBN cord-006856-b1w25ob5 887 36 . . . cord-006856-b1w25ob5 888 1 With with IN cord-006856-b1w25ob5 888 2 the the DT cord-006856-b1w25ob5 888 3 particular particular JJ cord-006856-b1w25ob5 888 4 focus focus NN cord-006856-b1w25ob5 888 5 on on IN cord-006856-b1w25ob5 888 6 donor donor NN cord-006856-b1w25ob5 888 7 safety safety NN cord-006856-b1w25ob5 888 8 , , , cord-006856-b1w25ob5 888 9 a a DT cord-006856-b1w25ob5 888 10 standardized standardized JJ cord-006856-b1w25ob5 888 11 approach approach NN cord-006856-b1w25ob5 888 12 to to IN cord-006856-b1w25ob5 888 13 data datum NNS cord-006856-b1w25ob5 888 14 collection collection NN cord-006856-b1w25ob5 888 15 of of IN cord-006856-b1w25ob5 888 16 follow follow NN cord-006856-b1w25ob5 888 17 - - HYPH cord-006856-b1w25ob5 888 18 ups up NNS cord-006856-b1w25ob5 888 19 to to TO cord-006856-b1w25ob5 888 20 monitor monitor VB cord-006856-b1w25ob5 888 21 short short JJ cord-006856-b1w25ob5 888 22 - - HYPH cord-006856-b1w25ob5 888 23 and and CC cord-006856-b1w25ob5 888 24 long long JJ cord-006856-b1w25ob5 888 25 - - HYPH cord-006856-b1w25ob5 888 26 term term NN cord-006856-b1w25ob5 888 27 effects effect NNS cord-006856-b1w25ob5 888 28 in in IN cord-006856-b1w25ob5 888 29 all all DT cord-006856-b1w25ob5 888 30 centers center NNS cord-006856-b1w25ob5 888 31 should should MD cord-006856-b1w25ob5 888 32 be be VB cord-006856-b1w25ob5 888 33 established establish VBN cord-006856-b1w25ob5 888 34 . . . cord-006856-b1w25ob5 889 1 Background background NN cord-006856-b1w25ob5 889 2 . . . cord-006856-b1w25ob5 890 1 Donor donor NN cord-006856-b1w25ob5 890 2 - - HYPH cord-006856-b1w25ob5 890 3 recipient recipient NN cord-006856-b1w25ob5 890 4 sex sex NN cord-006856-b1w25ob5 890 5 mismatch mismatch NN cord-006856-b1w25ob5 890 6 is be VBZ cord-006856-b1w25ob5 890 7 an an DT cord-006856-b1w25ob5 890 8 established establish VBN cord-006856-b1w25ob5 890 9 risk risk NN cord-006856-b1w25ob5 890 10 factor factor NN cord-006856-b1w25ob5 890 11 for for IN cord-006856-b1w25ob5 890 12 poor poor JJ cord-006856-b1w25ob5 890 13 outcome outcome NN cord-006856-b1w25ob5 890 14 after after IN cord-006856-b1w25ob5 890 15 allogeneic allogeneic VBG cord-006856-b1w25ob5 890 16 myeloablative myeloablative JJ cord-006856-b1w25ob5 890 17 hematopoietic hematopoietic JJ cord-006856-b1w25ob5 890 18 stem stem NN cord-006856-b1w25ob5 890 19 cell cell NN cord-006856-b1w25ob5 890 20 transplantation transplantation NN cord-006856-b1w25ob5 890 21 ( ( -LRB- cord-006856-b1w25ob5 890 22 HSCT HSCT NNP cord-006856-b1w25ob5 890 23 ) ) -RRB- cord-006856-b1w25ob5 890 24 . . . cord-006856-b1w25ob5 891 1 The the DT cord-006856-b1w25ob5 891 2 risk risk NN cord-006856-b1w25ob5 891 3 of of IN cord-006856-b1w25ob5 891 4 transplant transplant NN cord-006856-b1w25ob5 891 5 - - HYPH cord-006856-b1w25ob5 891 6 related relate VBN cord-006856-b1w25ob5 891 7 mortality mortality NN cord-006856-b1w25ob5 891 8 ( ( -LRB- cord-006856-b1w25ob5 891 9 TRM TRM NNP cord-006856-b1w25ob5 891 10 ) ) -RRB- cord-006856-b1w25ob5 891 11 due due JJ cord-006856-b1w25ob5 891 12 to to IN cord-006856-b1w25ob5 891 13 graft graft NN cord-006856-b1w25ob5 891 14 - - HYPH cord-006856-b1w25ob5 891 15 versushost versushost NN cord-006856-b1w25ob5 891 16 disease disease NN cord-006856-b1w25ob5 891 17 ( ( -LRB- cord-006856-b1w25ob5 891 18 GvHD GvHD NNP cord-006856-b1w25ob5 891 19 ) ) -RRB- cord-006856-b1w25ob5 891 20 is be VBZ cord-006856-b1w25ob5 891 21 higher high JJR cord-006856-b1w25ob5 891 22 in in IN cord-006856-b1w25ob5 891 23 male male JJ cord-006856-b1w25ob5 891 24 recipients recipient NNS cord-006856-b1w25ob5 891 25 of of IN cord-006856-b1w25ob5 891 26 female female JJ cord-006856-b1w25ob5 891 27 stem stem NN cord-006856-b1w25ob5 891 28 cells cell NNS cord-006856-b1w25ob5 891 29 compared compare VBN cord-006856-b1w25ob5 891 30 with with IN cord-006856-b1w25ob5 891 31 female female JJ cord-006856-b1w25ob5 891 32 patients patient NNS cord-006856-b1w25ob5 891 33 receiving receive VBG cord-006856-b1w25ob5 891 34 a a DT cord-006856-b1w25ob5 891 35 graft graft NN cord-006856-b1w25ob5 891 36 from from IN cord-006856-b1w25ob5 891 37 a a DT cord-006856-b1w25ob5 891 38 female female JJ cord-006856-b1w25ob5 891 39 donor donor NN cord-006856-b1w25ob5 891 40 . . . cord-006856-b1w25ob5 892 1 With with IN cord-006856-b1w25ob5 892 2 longer long JJR cord-006856-b1w25ob5 892 3 follow follow NN cord-006856-b1w25ob5 892 4 - - HYPH cord-006856-b1w25ob5 892 5 up up NN cord-006856-b1w25ob5 892 6 , , , cord-006856-b1w25ob5 892 7 however however RB cord-006856-b1w25ob5 892 8 , , , cord-006856-b1w25ob5 892 9 the the DT cord-006856-b1w25ob5 892 10 graft graft NN cord-006856-b1w25ob5 892 11 - - HYPH cord-006856-b1w25ob5 892 12 versus versus IN cord-006856-b1w25ob5 892 13 - - HYPH cord-006856-b1w25ob5 892 14 leukemia leukemia NN cord-006856-b1w25ob5 892 15 ( ( -LRB- cord-006856-b1w25ob5 892 16 GvL gvl NN cord-006856-b1w25ob5 892 17 ) ) -RRB- cord-006856-b1w25ob5 892 18 effect effect NN cord-006856-b1w25ob5 892 19 due due IN cord-006856-b1w25ob5 892 20 to to IN cord-006856-b1w25ob5 892 21 HY HY NNP cord-006856-b1w25ob5 892 22 minor minor JJ cord-006856-b1w25ob5 892 23 histocompatibility histocompatibility NN cord-006856-b1w25ob5 892 24 antigen antigen NN cord-006856-b1w25ob5 892 25 mismatch mismatch NN cord-006856-b1w25ob5 892 26 may may MD cord-006856-b1w25ob5 892 27 predominate predominate VB cord-006856-b1w25ob5 892 28 . . . cord-006856-b1w25ob5 893 1 The the DT cord-006856-b1w25ob5 893 2 contribution contribution NN cord-006856-b1w25ob5 893 3 of of IN cord-006856-b1w25ob5 893 4 donor donor NN cord-006856-b1w25ob5 893 5 - - HYPH cord-006856-b1w25ob5 893 6 patient patient NN cord-006856-b1w25ob5 893 7 sex sex NN cord-006856-b1w25ob5 893 8 on on IN cord-006856-b1w25ob5 893 9 outcome outcome NN cord-006856-b1w25ob5 893 10 after after IN cord-006856-b1w25ob5 893 11 nonmyeloablative nonmyeloablative JJ cord-006856-b1w25ob5 893 12 HSCT HSCT NNP cord-006856-b1w25ob5 893 13 , , , cord-006856-b1w25ob5 893 14 however however RB cord-006856-b1w25ob5 893 15 , , , cord-006856-b1w25ob5 893 16 has have VBZ cord-006856-b1w25ob5 893 17 not not RB cord-006856-b1w25ob5 893 18 been be VBN cord-006856-b1w25ob5 893 19 examined examine VBN cord-006856-b1w25ob5 893 20 in in IN cord-006856-b1w25ob5 893 21 detail detail NN cord-006856-b1w25ob5 893 22 yet yet RB cord-006856-b1w25ob5 893 23 . . . cord-006856-b1w25ob5 894 1 Methods method NNS cord-006856-b1w25ob5 894 2 . . . cord-006856-b1w25ob5 895 1 We -PRON- PRP cord-006856-b1w25ob5 895 2 therefore therefore RB cord-006856-b1w25ob5 895 3 analyzed analyze VBD cord-006856-b1w25ob5 895 4 a a DT cord-006856-b1w25ob5 895 5 single single JJ cord-006856-b1w25ob5 895 6 - - HYPH cord-006856-b1w25ob5 895 7 center center NN cord-006856-b1w25ob5 895 8 cohort cohort NN cord-006856-b1w25ob5 895 9 of of IN cord-006856-b1w25ob5 895 10 72 72 CD cord-006856-b1w25ob5 895 11 high high JJ cord-006856-b1w25ob5 895 12 - - HYPH cord-006856-b1w25ob5 895 13 risk risk NN cord-006856-b1w25ob5 895 14 patients patient NNS cord-006856-b1w25ob5 895 15 transplanted transplant VBN cord-006856-b1w25ob5 895 16 with with IN cord-006856-b1w25ob5 895 17 a a DT cord-006856-b1w25ob5 895 18 related related JJ cord-006856-b1w25ob5 895 19 or or CC cord-006856-b1w25ob5 895 20 unrelated unrelated JJ cord-006856-b1w25ob5 895 21 stem stem NN cord-006856-b1w25ob5 895 22 cell cell NN cord-006856-b1w25ob5 895 23 graft graft NN cord-006856-b1w25ob5 895 24 after after IN cord-006856-b1w25ob5 895 25 nonmyeloablative nonmyeloablative JJ cord-006856-b1w25ob5 895 26 conditioning conditioning NN cord-006856-b1w25ob5 895 27 for for IN cord-006856-b1w25ob5 895 28 outcome outcome NN cord-006856-b1w25ob5 895 29 ( ( -LRB- cord-006856-b1w25ob5 895 30 acute acute JJ cord-006856-b1w25ob5 895 31 and and CC cord-006856-b1w25ob5 895 32 chronic chronic JJ cord-006856-b1w25ob5 895 33 GvHD gvhd NN cord-006856-b1w25ob5 895 34 , , , cord-006856-b1w25ob5 895 35 TRM TRM NNP cord-006856-b1w25ob5 895 36 , , , cord-006856-b1w25ob5 895 37 relapse relapse NN cord-006856-b1w25ob5 895 38 , , , cord-006856-b1w25ob5 895 39 and and CC cord-006856-b1w25ob5 895 40 survival survival NN cord-006856-b1w25ob5 895 41 ) ) -RRB- cord-006856-b1w25ob5 895 42 . . . cord-006856-b1w25ob5 896 1 Results result NNS cord-006856-b1w25ob5 896 2 . . . cord-006856-b1w25ob5 897 1 Of of IN cord-006856-b1w25ob5 897 2 the the DT cord-006856-b1w25ob5 897 3 72 72 CD cord-006856-b1w25ob5 897 4 patients patient NNS cord-006856-b1w25ob5 897 5 , , , cord-006856-b1w25ob5 897 6 19 19 CD cord-006856-b1w25ob5 897 7 male male JJ cord-006856-b1w25ob5 897 8 patients patient NNS cord-006856-b1w25ob5 897 9 received receive VBD cord-006856-b1w25ob5 897 10 a a DT cord-006856-b1w25ob5 897 11 graft graft NN cord-006856-b1w25ob5 897 12 from from IN cord-006856-b1w25ob5 897 13 a a DT cord-006856-b1w25ob5 897 14 female female JJ cord-006856-b1w25ob5 897 15 donor donor NN cord-006856-b1w25ob5 897 16 , , , cord-006856-b1w25ob5 897 17 21 21 CD cord-006856-b1w25ob5 897 18 males male NNS cord-006856-b1w25ob5 897 19 a a DT cord-006856-b1w25ob5 897 20 graft graft NN cord-006856-b1w25ob5 897 21 from from IN cord-006856-b1w25ob5 897 22 a a DT cord-006856-b1w25ob5 897 23 male male JJ cord-006856-b1w25ob5 897 24 donor donor NN cord-006856-b1w25ob5 897 25 . . . cord-006856-b1w25ob5 898 1 Sixteen sixteen CD cord-006856-b1w25ob5 898 2 female female JJ cord-006856-b1w25ob5 898 3 donors donor NNS cord-006856-b1w25ob5 898 4 were be VBD cord-006856-b1w25ob5 898 5 transplanted transplant VBN cord-006856-b1w25ob5 898 6 with with IN cord-006856-b1w25ob5 898 7 a a DT cord-006856-b1w25ob5 898 8 male male JJ cord-006856-b1w25ob5 898 9 donor donor NN cord-006856-b1w25ob5 898 10 and and CC cord-006856-b1w25ob5 898 11 16 16 CD cord-006856-b1w25ob5 898 12 with with IN cord-006856-b1w25ob5 898 13 a a DT cord-006856-b1w25ob5 898 14 female female JJ cord-006856-b1w25ob5 898 15 donor donor NN cord-006856-b1w25ob5 898 16 . . . cord-006856-b1w25ob5 899 1 Around around IN cord-006856-b1w25ob5 899 2 30 30 CD cord-006856-b1w25ob5 899 3 % % NN cord-006856-b1w25ob5 899 4 of of IN cord-006856-b1w25ob5 899 5 the the DT cord-006856-b1w25ob5 899 6 patients patient NNS cord-006856-b1w25ob5 899 7 with with IN cord-006856-b1w25ob5 899 8 a a DT cord-006856-b1w25ob5 899 9 sex sex NN cord-006856-b1w25ob5 899 10 - - HYPH cord-006856-b1w25ob5 899 11 mismatched mismatch VBN cord-006856-b1w25ob5 899 12 donor donor NN cord-006856-b1w25ob5 899 13 received receive VBD cord-006856-b1w25ob5 899 14 stem stem NN cord-006856-b1w25ob5 899 15 cells cell NNS cord-006856-b1w25ob5 899 16 with with IN cord-006856-b1w25ob5 899 17 an an DT cord-006856-b1w25ob5 899 18 HLA HLA NNP cord-006856-b1w25ob5 899 19 mismatch mismatch NN cord-006856-b1w25ob5 899 20 compared compare VBN cord-006856-b1w25ob5 899 21 to to IN cord-006856-b1w25ob5 899 22 10 10 CD cord-006856-b1w25ob5 899 23 % % NN cord-006856-b1w25ob5 899 24 of of IN cord-006856-b1w25ob5 899 25 the the DT cord-006856-b1w25ob5 899 26 patients patient NNS cord-006856-b1w25ob5 899 27 without without IN cord-006856-b1w25ob5 899 28 sex sex NN cord-006856-b1w25ob5 899 29 - - HYPH cord-006856-b1w25ob5 899 30 mis mis NNP cord-006856-b1w25ob5 899 31 - - HYPH cord-006856-b1w25ob5 899 32 Stammzellen Stammzellen NNP cord-006856-b1w25ob5 899 33 matched match VBN cord-006856-b1w25ob5 899 34 donor donor NN cord-006856-b1w25ob5 899 35 , , , cord-006856-b1w25ob5 899 36 the the DT cord-006856-b1w25ob5 899 37 other other JJ cord-006856-b1w25ob5 899 38 clinical clinical JJ cord-006856-b1w25ob5 899 39 differences difference NNS cord-006856-b1w25ob5 899 40 were be VBD cord-006856-b1w25ob5 899 41 similar similar JJ cord-006856-b1w25ob5 899 42 between between IN cord-006856-b1w25ob5 899 43 all all DT cord-006856-b1w25ob5 899 44 groups group NNS cord-006856-b1w25ob5 899 45 . . . cord-006856-b1w25ob5 900 1 The the DT cord-006856-b1w25ob5 900 2 highest high JJS cord-006856-b1w25ob5 900 3 cumulative cumulative JJ cord-006856-b1w25ob5 900 4 incidence incidence NN cord-006856-b1w25ob5 900 5 for for IN cord-006856-b1w25ob5 900 6 acute acute JJ cord-006856-b1w25ob5 900 7 and and CC cord-006856-b1w25ob5 900 8 chronic chronic JJ cord-006856-b1w25ob5 900 9 GvHD gvhd NN cord-006856-b1w25ob5 900 10 was be VBD cord-006856-b1w25ob5 900 11 detected detect VBN cord-006856-b1w25ob5 900 12 in in IN cord-006856-b1w25ob5 900 13 male male JJ cord-006856-b1w25ob5 900 14 patients patient NNS cord-006856-b1w25ob5 900 15 receiving receive VBG cord-006856-b1w25ob5 900 16 a a DT cord-006856-b1w25ob5 900 17 stem stem NN cord-006856-b1w25ob5 900 18 cell cell NN cord-006856-b1w25ob5 900 19 graft graft NN cord-006856-b1w25ob5 900 20 from from IN cord-006856-b1w25ob5 900 21 a a DT cord-006856-b1w25ob5 900 22 male male JJ cord-006856-b1w25ob5 900 23 donor donor NN cord-006856-b1w25ob5 900 24 ( ( -LRB- cord-006856-b1w25ob5 900 25 52.4 52.4 CD cord-006856-b1w25ob5 900 26 % % NN cord-006856-b1w25ob5 900 27 and and CC cord-006856-b1w25ob5 900 28 53.3 53.3 CD cord-006856-b1w25ob5 900 29 % % NN cord-006856-b1w25ob5 900 30 , , , cord-006856-b1w25ob5 900 31 respectively respectively RB cord-006856-b1w25ob5 900 32 ) ) -RRB- cord-006856-b1w25ob5 900 33 . . . cord-006856-b1w25ob5 901 1 The the DT cord-006856-b1w25ob5 901 2 highest high JJS cord-006856-b1w25ob5 901 3 relapse relapse NN cord-006856-b1w25ob5 901 4 incidence incidence NN cord-006856-b1w25ob5 901 5 ( ( -LRB- cord-006856-b1w25ob5 901 6 55.6 55.6 CD cord-006856-b1w25ob5 901 7 % % NN cord-006856-b1w25ob5 901 8 ) ) -RRB- cord-006856-b1w25ob5 901 9 was be VBD cord-006856-b1w25ob5 901 10 detected detect VBN cord-006856-b1w25ob5 901 11 in in IN cord-006856-b1w25ob5 901 12 male male JJ cord-006856-b1w25ob5 901 13 patients patient NNS cord-006856-b1w25ob5 901 14 transplanted transplant VBN cord-006856-b1w25ob5 901 15 with with IN cord-006856-b1w25ob5 901 16 a a DT cord-006856-b1w25ob5 901 17 female female JJ cord-006856-b1w25ob5 901 18 donor donor NN cord-006856-b1w25ob5 901 19 . . . cord-006856-b1w25ob5 902 1 This this DT cord-006856-b1w25ob5 902 2 was be VBD cord-006856-b1w25ob5 902 3 borderline borderline JJ cord-006856-b1w25ob5 902 4 significant significant JJ cord-006856-b1w25ob5 902 5 ( ( -LRB- cord-006856-b1w25ob5 902 6 P p NN cord-006856-b1w25ob5 902 7 = = SYM cord-006856-b1w25ob5 902 8 0.0845 0.0845 CD cord-006856-b1w25ob5 902 9 ) ) -RRB- cord-006856-b1w25ob5 902 10 to to IN cord-006856-b1w25ob5 902 11 female female JJ cord-006856-b1w25ob5 902 12 patients patient NNS cord-006856-b1w25ob5 902 13 receiving receive VBG cord-006856-b1w25ob5 902 14 a a DT cord-006856-b1w25ob5 902 15 female female JJ cord-006856-b1w25ob5 902 16 graft graft NN cord-006856-b1w25ob5 902 17 ( ( -LRB- cord-006856-b1w25ob5 902 18 20 20 CD cord-006856-b1w25ob5 902 19 % % NN cord-006856-b1w25ob5 902 20 relapse relapse NN cord-006856-b1w25ob5 902 21 incidence incidence NN cord-006856-b1w25ob5 902 22 ) ) -RRB- cord-006856-b1w25ob5 902 23 and and CC cord-006856-b1w25ob5 902 24 argues argue VBZ cord-006856-b1w25ob5 902 25 against against IN cord-006856-b1w25ob5 902 26 an an DT cord-006856-b1w25ob5 902 27 effective effective JJ cord-006856-b1w25ob5 902 28 anti anti JJ cord-006856-b1w25ob5 902 29 - - JJ cord-006856-b1w25ob5 902 30 HY hy JJ cord-006856-b1w25ob5 902 31 response response NN cord-006856-b1w25ob5 902 32 in in IN cord-006856-b1w25ob5 902 33 this this DT cord-006856-b1w25ob5 902 34 patient patient JJ cord-006856-b1w25ob5 902 35 cohort cohort NN cord-006856-b1w25ob5 902 36 . . . cord-006856-b1w25ob5 903 1 The the DT cord-006856-b1w25ob5 903 2 mean mean JJ cord-006856-b1w25ob5 903 3 cumulative cumulative JJ cord-006856-b1w25ob5 903 4 incidence incidence NN cord-006856-b1w25ob5 903 5 for for IN cord-006856-b1w25ob5 903 6 TRM TRM NNP cord-006856-b1w25ob5 903 7 was be VBD cord-006856-b1w25ob5 903 8 57.3 57.3 CD cord-006856-b1w25ob5 903 9 % % NN cord-006856-b1w25ob5 903 10 ; ; , cord-006856-b1w25ob5 903 11 however however RB cord-006856-b1w25ob5 903 12 , , , cord-006856-b1w25ob5 903 13 female female JJ cord-006856-b1w25ob5 903 14 recipients recipient NNS cord-006856-b1w25ob5 903 15 receiving receive VBG cord-006856-b1w25ob5 903 16 a a DT cord-006856-b1w25ob5 903 17 graft graft NN cord-006856-b1w25ob5 903 18 from from IN cord-006856-b1w25ob5 903 19 a a DT cord-006856-b1w25ob5 903 20 female female JJ cord-006856-b1w25ob5 903 21 donor donor NN cord-006856-b1w25ob5 903 22 displayed display VBD cord-006856-b1w25ob5 903 23 an an DT cord-006856-b1w25ob5 903 24 unexpectedly unexpectedly RB cord-006856-b1w25ob5 903 25 high high JJ cord-006856-b1w25ob5 903 26 incidence incidence NN cord-006856-b1w25ob5 903 27 for for IN cord-006856-b1w25ob5 903 28 TRM TRM NNP cord-006856-b1w25ob5 903 29 ( ( -LRB- cord-006856-b1w25ob5 903 30 87.5 87.5 CD cord-006856-b1w25ob5 903 31 % % NN cord-006856-b1w25ob5 903 32 ) ) -RRB- cord-006856-b1w25ob5 903 33 which which WDT cord-006856-b1w25ob5 903 34 could could MD cord-006856-b1w25ob5 903 35 not not RB cord-006856-b1w25ob5 903 36 be be VB cord-006856-b1w25ob5 903 37 explained explain VBN cord-006856-b1w25ob5 903 38 by by IN cord-006856-b1w25ob5 903 39 clinical clinical JJ cord-006856-b1w25ob5 903 40 characteristics characteristic NNS cord-006856-b1w25ob5 903 41 . . . cord-006856-b1w25ob5 904 1 The the DT cord-006856-b1w25ob5 904 2 overall overall JJ cord-006856-b1w25ob5 904 3 survival survival NN cord-006856-b1w25ob5 904 4 of of IN cord-006856-b1w25ob5 904 5 41 41 CD cord-006856-b1w25ob5 904 6 % % NN cord-006856-b1w25ob5 904 7 2.5 2.5 CD cord-006856-b1w25ob5 904 8 years year NNS cord-006856-b1w25ob5 904 9 after after IN cord-006856-b1w25ob5 904 10 transplant transplant NN cord-006856-b1w25ob5 904 11 in in IN cord-006856-b1w25ob5 904 12 this this DT cord-006856-b1w25ob5 904 13 group group NN cord-006856-b1w25ob5 904 14 , , , cord-006856-b1w25ob5 904 15 however however RB cord-006856-b1w25ob5 904 16 , , , cord-006856-b1w25ob5 904 17 was be VBD cord-006856-b1w25ob5 904 18 not not RB cord-006856-b1w25ob5 904 19 different different JJ cord-006856-b1w25ob5 904 20 from from IN cord-006856-b1w25ob5 904 21 male male JJ cord-006856-b1w25ob5 904 22 patients patient NNS cord-006856-b1w25ob5 904 23 receiving receive VBG cord-006856-b1w25ob5 904 24 a a DT cord-006856-b1w25ob5 904 25 female female JJ cord-006856-b1w25ob5 904 26 graft graft NN cord-006856-b1w25ob5 904 27 ( ( -LRB- cord-006856-b1w25ob5 904 28 43.7 43.7 CD cord-006856-b1w25ob5 904 29 % % NN cord-006856-b1w25ob5 904 30 at at IN cord-006856-b1w25ob5 904 31 1.4 1.4 CD cord-006856-b1w25ob5 904 32 years year NNS cord-006856-b1w25ob5 904 33 after after IN cord-006856-b1w25ob5 904 34 transplant transplant NN cord-006856-b1w25ob5 904 35 ) ) -RRB- cord-006856-b1w25ob5 904 36 . . . cord-006856-b1w25ob5 905 1 The the DT cord-006856-b1w25ob5 905 2 overall overall JJ cord-006856-b1w25ob5 905 3 survival survival NN cord-006856-b1w25ob5 905 4 from from IN cord-006856-b1w25ob5 905 5 male male JJ cord-006856-b1w25ob5 905 6 patients patient NNS cord-006856-b1w25ob5 905 7 with with IN cord-006856-b1w25ob5 905 8 a a DT cord-006856-b1w25ob5 905 9 male male JJ cord-006856-b1w25ob5 905 10 donor donor NN cord-006856-b1w25ob5 905 11 was be VBD cord-006856-b1w25ob5 905 12 slightly slightly RB cord-006856-b1w25ob5 905 13 lower low JJR cord-006856-b1w25ob5 905 14 ( ( -LRB- cord-006856-b1w25ob5 905 15 33 33 CD cord-006856-b1w25ob5 905 16 % % NN cord-006856-b1w25ob5 905 17 at at IN cord-006856-b1w25ob5 905 18 2.5 2.5 CD cord-006856-b1w25ob5 905 19 years year NNS cord-006856-b1w25ob5 905 20 after after IN cord-006856-b1w25ob5 905 21 transplant transplant NN cord-006856-b1w25ob5 905 22 ) ) -RRB- cord-006856-b1w25ob5 905 23 compared compare VBN cord-006856-b1w25ob5 905 24 with with IN cord-006856-b1w25ob5 905 25 female female JJ cord-006856-b1w25ob5 905 26 patients patient NNS cord-006856-b1w25ob5 905 27 transplanted transplant VBN cord-006856-b1w25ob5 905 28 with with IN cord-006856-b1w25ob5 905 29 male male JJ cord-006856-b1w25ob5 905 30 stem stem NN cord-006856-b1w25ob5 905 31 cells cell NNS cord-006856-b1w25ob5 905 32 ( ( -LRB- cord-006856-b1w25ob5 905 33 47.4 47.4 CD cord-006856-b1w25ob5 905 34 % % NN cord-006856-b1w25ob5 905 35 at at IN cord-006856-b1w25ob5 905 36 1.4 1.4 CD cord-006856-b1w25ob5 905 37 years year NNS cord-006856-b1w25ob5 905 38 after after IN cord-006856-b1w25ob5 905 39 transplant transplant NN cord-006856-b1w25ob5 905 40 ) ) -RRB- cord-006856-b1w25ob5 905 41 . . . cord-006856-b1w25ob5 906 1 Conclusions conclusion NNS cord-006856-b1w25ob5 906 2 . . . cord-006856-b1w25ob5 907 1 These these DT cord-006856-b1w25ob5 907 2 data datum NNS cord-006856-b1w25ob5 907 3 , , , cord-006856-b1w25ob5 907 4 analyzed analyze VBN cord-006856-b1w25ob5 907 5 in in IN cord-006856-b1w25ob5 907 6 a a DT cord-006856-b1w25ob5 907 7 small small JJ cord-006856-b1w25ob5 907 8 cohort cohort NN cord-006856-b1w25ob5 907 9 of of IN cord-006856-b1w25ob5 907 10 patients patient NNS cord-006856-b1w25ob5 907 11 , , , cord-006856-b1w25ob5 907 12 show show VBP cord-006856-b1w25ob5 907 13 that that IN cord-006856-b1w25ob5 907 14 a a DT cord-006856-b1w25ob5 907 15 sex sex NN cord-006856-b1w25ob5 907 16 mismatch mismatch NN cord-006856-b1w25ob5 907 17 between between IN cord-006856-b1w25ob5 907 18 patient patient NN cord-006856-b1w25ob5 907 19 and and CC cord-006856-b1w25ob5 907 20 donor donor NN cord-006856-b1w25ob5 907 21 may may MD cord-006856-b1w25ob5 907 22 have have VB cord-006856-b1w25ob5 907 23 a a DT cord-006856-b1w25ob5 907 24 negative negative JJ cord-006856-b1w25ob5 907 25 impact impact NN cord-006856-b1w25ob5 907 26 also also RB cord-006856-b1w25ob5 907 27 on on IN cord-006856-b1w25ob5 907 28 outcome outcome NN cord-006856-b1w25ob5 907 29 after after IN cord-006856-b1w25ob5 907 30 nonmyeloablative nonmyeloablative JJ cord-006856-b1w25ob5 907 31 HSCT HSCT NNP cord-006856-b1w25ob5 907 32 . . . cord-006856-b1w25ob5 908 1 However however RB cord-006856-b1w25ob5 908 2 , , , cord-006856-b1w25ob5 908 3 studies study NNS cord-006856-b1w25ob5 908 4 with with IN cord-006856-b1w25ob5 908 5 larger large JJR cord-006856-b1w25ob5 908 6 and and CC cord-006856-b1w25ob5 908 7 homogeneous homogeneous JJ cord-006856-b1w25ob5 908 8 cohorts cohort NNS cord-006856-b1w25ob5 908 9 have have VBP cord-006856-b1w25ob5 908 10 to to TO cord-006856-b1w25ob5 908 11 be be VB cord-006856-b1w25ob5 908 12 performed perform VBN cord-006856-b1w25ob5 908 13 to to TO cord-006856-b1w25ob5 908 14 prove prove VB cord-006856-b1w25ob5 908 15 these these DT cord-006856-b1w25ob5 908 16 findings finding NNS cord-006856-b1w25ob5 908 17 . . . cord-006856-b1w25ob5 909 1 Between between IN cord-006856-b1w25ob5 909 2 1995 1995 CD cord-006856-b1w25ob5 909 3 and and CC cord-006856-b1w25ob5 909 4 2004 2004 CD cord-006856-b1w25ob5 909 5 , , , cord-006856-b1w25ob5 909 6 20 20 CD cord-006856-b1w25ob5 909 7 patients patient NNS cord-006856-b1w25ob5 909 8 with with IN cord-006856-b1w25ob5 909 9 chronic chronic JJ cord-006856-b1w25ob5 909 10 lymphoid lymphoid JJ cord-006856-b1w25ob5 909 11 leukemia leukemia NN cord-006856-b1w25ob5 909 12 ( ( -LRB- cord-006856-b1w25ob5 909 13 CLL CLL NNP cord-006856-b1w25ob5 909 14 ) ) -RRB- cord-006856-b1w25ob5 909 15 , , , cord-006856-b1w25ob5 909 16 Binet Binet NNP cord-006856-b1w25ob5 909 17 stage stage NN cord-006856-b1w25ob5 909 18 B B NNP cord-006856-b1w25ob5 909 19 or or CC cord-006856-b1w25ob5 909 20 C C NNP cord-006856-b1w25ob5 909 21 ( ( -LRB- cord-006856-b1w25ob5 909 22 n n NN cord-006856-b1w25ob5 909 23 = = SYM cord-006856-b1w25ob5 909 24 19 19 CD cord-006856-b1w25ob5 909 25 ) ) -RRB- cord-006856-b1w25ob5 909 26 or or CC cord-006856-b1w25ob5 909 27 A a DT cord-006856-b1w25ob5 909 28 with with IN cord-006856-b1w25ob5 909 29 risk risk NN cord-006856-b1w25ob5 909 30 factors factor NNS cord-006856-b1w25ob5 909 31 ( ( -LRB- cord-006856-b1w25ob5 909 32 n n NN cord-006856-b1w25ob5 909 33 = = SYM cord-006856-b1w25ob5 909 34 1 1 CD cord-006856-b1w25ob5 909 35 ) ) -RRB- cord-006856-b1w25ob5 909 36 with with IN cord-006856-b1w25ob5 909 37 a a DT cord-006856-b1w25ob5 909 38 median median JJ cord-006856-b1w25ob5 909 39 age age NN cord-006856-b1w25ob5 909 40 of of IN cord-006856-b1w25ob5 909 41 53 53 CD cord-006856-b1w25ob5 909 42 ( ( -LRB- cord-006856-b1w25ob5 909 43 range range NN cord-006856-b1w25ob5 909 44 , , , cord-006856-b1w25ob5 909 45 27 27 CD cord-006856-b1w25ob5 909 46 - - SYM cord-006856-b1w25ob5 909 47 62 62 CD cord-006856-b1w25ob5 909 48 ) ) -RRB- cord-006856-b1w25ob5 909 49 years year NNS cord-006856-b1w25ob5 909 50 underwent undergo VBD cord-006856-b1w25ob5 909 51 autologous autologous JJ cord-006856-b1w25ob5 909 52 ( ( -LRB- cord-006856-b1w25ob5 909 53 n n NN cord-006856-b1w25ob5 909 54 = = SYM cord-006856-b1w25ob5 909 55 11 11 CD cord-006856-b1w25ob5 909 56 ) ) -RRB- cord-006856-b1w25ob5 909 57 or or CC cord-006856-b1w25ob5 909 58 allogeneic allogeneic JJ cord-006856-b1w25ob5 909 59 ( ( -LRB- cord-006856-b1w25ob5 909 60 n n NN cord-006856-b1w25ob5 909 61 = = SYM cord-006856-b1w25ob5 909 62 9 9 CD cord-006856-b1w25ob5 909 63 ) ) -RRB- cord-006856-b1w25ob5 909 64 hematopoietic hematopoietic JJ cord-006856-b1w25ob5 909 65 stem stem NN cord-006856-b1w25ob5 909 66 cell cell NN cord-006856-b1w25ob5 909 67 transplantation transplantation NN cord-006856-b1w25ob5 909 68 ( ( -LRB- cord-006856-b1w25ob5 909 69 HSCT HSCT NNP cord-006856-b1w25ob5 909 70 ) ) -RRB- cord-006856-b1w25ob5 909 71 at at IN cord-006856-b1w25ob5 909 72 the the DT cord-006856-b1w25ob5 909 73 Medical Medical NNP cord-006856-b1w25ob5 909 74 University University NNP cord-006856-b1w25ob5 909 75 of of IN cord-006856-b1w25ob5 909 76 Vienna Vienna NNP cord-006856-b1w25ob5 909 77 . . . cord-006856-b1w25ob5 910 1 The the DT cord-006856-b1w25ob5 910 2 median median JJ cord-006856-b1w25ob5 910 3 time time NN cord-006856-b1w25ob5 910 4 from from IN cord-006856-b1w25ob5 910 5 diagnosis diagnosis NN cord-006856-b1w25ob5 910 6 to to IN cord-006856-b1w25ob5 910 7 HSCT HSCT NNP cord-006856-b1w25ob5 910 8 was be VBD cord-006856-b1w25ob5 910 9 29 29 CD cord-006856-b1w25ob5 911 1 ( ( -LRB- cord-006856-b1w25ob5 911 2 range range NN cord-006856-b1w25ob5 911 3 , , , cord-006856-b1w25ob5 911 4 6 6 CD cord-006856-b1w25ob5 911 5 - - SYM cord-006856-b1w25ob5 911 6 77 77 CD cord-006856-b1w25ob5 911 7 ) ) -RRB- cord-006856-b1w25ob5 911 8 months month NNS cord-006856-b1w25ob5 911 9 . . . cord-006856-b1w25ob5 912 1 Eleven eleven CD cord-006856-b1w25ob5 912 2 patients patient NNS cord-006856-b1w25ob5 912 3 underwent undergo VBD cord-006856-b1w25ob5 912 4 autologous autologous JJ cord-006856-b1w25ob5 912 5 stem stem NN cord-006856-b1w25ob5 912 6 cell cell NN cord-006856-b1w25ob5 912 7 transplantation transplantation NN cord-006856-b1w25ob5 912 8 ( ( -LRB- cord-006856-b1w25ob5 912 9 ASCT ASCT NNP cord-006856-b1w25ob5 912 10 ) ) -RRB- cord-006856-b1w25ob5 912 11 in in IN cord-006856-b1w25ob5 912 12 partial partial JJ cord-006856-b1w25ob5 912 13 remission remission NN cord-006856-b1w25ob5 912 14 ( ( -LRB- cord-006856-b1w25ob5 912 15 n n NN cord-006856-b1w25ob5 912 16 = = SYM cord-006856-b1w25ob5 912 17 9 9 CD cord-006856-b1w25ob5 912 18 ) ) -RRB- cord-006856-b1w25ob5 912 19 or or CC cord-006856-b1w25ob5 912 20 complete complete JJ cord-006856-b1w25ob5 912 21 remission remission NN cord-006856-b1w25ob5 912 22 ( ( -LRB- cord-006856-b1w25ob5 912 23 CR CR NNP cord-006856-b1w25ob5 912 24 ) ) -RRB- cord-006856-b1w25ob5 912 25 ( ( -LRB- cord-006856-b1w25ob5 912 26 n n NN cord-006856-b1w25ob5 912 27 = = SYM cord-006856-b1w25ob5 912 28 2 2 CD cord-006856-b1w25ob5 912 29 ) ) -RRB- cord-006856-b1w25ob5 912 30 and and CC cord-006856-b1w25ob5 912 31 received receive VBD cord-006856-b1w25ob5 912 32 Bcell Bcell NNP cord-006856-b1w25ob5 912 33 - - HYPH cord-006856-b1w25ob5 912 34 depleted deplete VBN cord-006856-b1w25ob5 912 35 peripheral peripheral JJ cord-006856-b1w25ob5 912 36 blood blood NN cord-006856-b1w25ob5 912 37 stem stem NN cord-006856-b1w25ob5 912 38 cell cell NN cord-006856-b1w25ob5 912 39 ( ( -LRB- cord-006856-b1w25ob5 912 40 PBSC PBSC NNP cord-006856-b1w25ob5 912 41 ) ) -RRB- cord-006856-b1w25ob5 912 42 grafts graft NNS cord-006856-b1w25ob5 912 43 . . . cord-006856-b1w25ob5 913 1 Nine nine CD cord-006856-b1w25ob5 913 2 patients patient NNS cord-006856-b1w25ob5 913 3 with with IN cord-006856-b1w25ob5 913 4 refractory refractory JJ cord-006856-b1w25ob5 913 5 disease disease NN cord-006856-b1w25ob5 913 6 ( ( -LRB- cord-006856-b1w25ob5 913 7 n n NN cord-006856-b1w25ob5 913 8 = = SYM cord-006856-b1w25ob5 913 9 6 6 CD cord-006856-b1w25ob5 913 10 ) ) -RRB- cord-006856-b1w25ob5 913 11 or or CC cord-006856-b1w25ob5 913 12 chemosensitive chemosensitive JJ cord-006856-b1w25ob5 913 13 relapse relapse NN cord-006856-b1w25ob5 914 1 ( ( -LRB- cord-006856-b1w25ob5 914 2 n n NN cord-006856-b1w25ob5 914 3 = = SYM cord-006856-b1w25ob5 914 4 3 3 CD cord-006856-b1w25ob5 914 5 ) ) -RRB- cord-006856-b1w25ob5 914 6 underwent undergo VBD cord-006856-b1w25ob5 914 7 allogeneic allogeneic NN cord-006856-b1w25ob5 914 8 HSCT HSCT NNP cord-006856-b1w25ob5 914 9 with with IN cord-006856-b1w25ob5 914 10 unmanipulated unmanipulated JJ cord-006856-b1w25ob5 914 11 bone bone NN cord-006856-b1w25ob5 914 12 marrow marrow NN cord-006856-b1w25ob5 914 13 ( ( -LRB- cord-006856-b1w25ob5 914 14 n n NN cord-006856-b1w25ob5 914 15 = = SYM cord-006856-b1w25ob5 914 16 3 3 CD cord-006856-b1w25ob5 914 17 ) ) -RRB- cord-006856-b1w25ob5 914 18 or or CC cord-006856-b1w25ob5 914 19 PBSC PBSC NNP cord-006856-b1w25ob5 914 20 ( ( -LRB- cord-006856-b1w25ob5 914 21 n n NN cord-006856-b1w25ob5 914 22 = = SYM cord-006856-b1w25ob5 914 23 6 6 CD cord-006856-b1w25ob5 914 24 ) ) -RRB- cord-006856-b1w25ob5 914 25 from from IN cord-006856-b1w25ob5 914 26 sibling sibling NN cord-006856-b1w25ob5 914 27 ( ( -LRB- cord-006856-b1w25ob5 914 28 n n NN cord-006856-b1w25ob5 914 29 = = SYM cord-006856-b1w25ob5 914 30 8) 8) NN cord-006856-b1w25ob5 914 31 or or CC cord-006856-b1w25ob5 914 32 unrelated unrelated JJ cord-006856-b1w25ob5 914 33 ( ( -LRB- cord-006856-b1w25ob5 914 34 n n NN cord-006856-b1w25ob5 914 35 = = SYM cord-006856-b1w25ob5 914 36 1 1 CD cord-006856-b1w25ob5 914 37 ) ) -RRB- cord-006856-b1w25ob5 914 38 donors donor NNS cord-006856-b1w25ob5 914 39 . . . cord-006856-b1w25ob5 915 1 In in IN cord-006856-b1w25ob5 915 2 the the DT cord-006856-b1w25ob5 915 3 majority majority NN cord-006856-b1w25ob5 915 4 , , , cord-006856-b1w25ob5 915 5 conditioning conditioning NN cord-006856-b1w25ob5 915 6 therapy therapy NN cord-006856-b1w25ob5 915 7 consisted consist VBD cord-006856-b1w25ob5 915 8 of of IN cord-006856-b1w25ob5 915 9 total total JJ cord-006856-b1w25ob5 915 10 - - HYPH cord-006856-b1w25ob5 915 11 body body NN cord-006856-b1w25ob5 915 12 irradiation irradiation NN cord-006856-b1w25ob5 915 13 ( ( -LRB- cord-006856-b1w25ob5 915 14 TBI TBI NNP cord-006856-b1w25ob5 915 15 ) ) -RRB- cord-006856-b1w25ob5 915 16 of of IN cord-006856-b1w25ob5 915 17 12 12 CD cord-006856-b1w25ob5 915 18 - - SYM cord-006856-b1w25ob5 915 19 13.2 13.2 CD cord-006856-b1w25ob5 915 20 Gy Gy NNP cord-006856-b1w25ob5 915 21 and and CC cord-006856-b1w25ob5 915 22 cyclophosphamide cyclophosphamide RB cord-006856-b1w25ob5 915 23 . . . cord-006856-b1w25ob5 916 1 Three three CD cord-006856-b1w25ob5 916 2 patients patient NNS cord-006856-b1w25ob5 916 3 underwent undergo VBD cord-006856-b1w25ob5 916 4 reduced reduce VBN cord-006856-b1w25ob5 916 5 - - HYPH cord-006856-b1w25ob5 916 6 intensity intensity NN cord-006856-b1w25ob5 916 7 conditioning conditioning NN cord-006856-b1w25ob5 916 8 ( ( -LRB- cord-006856-b1w25ob5 916 9 RIC RIC NNP cord-006856-b1w25ob5 916 10 ) ) -RRB- cord-006856-b1w25ob5 916 11 with with IN cord-006856-b1w25ob5 916 12 fludarabine fludarabine NN cord-006856-b1w25ob5 916 13 and and CC cord-006856-b1w25ob5 916 14 TBI TBI NNP cord-006856-b1w25ob5 916 15 of of IN cord-006856-b1w25ob5 916 16 2 2 CD cord-006856-b1w25ob5 916 17 Gy Gy NNP cord-006856-b1w25ob5 916 18 . . . cord-006856-b1w25ob5 917 1 Graft graft NN cord-006856-b1w25ob5 917 2 - - HYPH cord-006856-b1w25ob5 917 3 versus versus IN cord-006856-b1w25ob5 917 4 - - HYPH cord-006856-b1w25ob5 917 5 host host NN cord-006856-b1w25ob5 917 6 disease disease NN cord-006856-b1w25ob5 917 7 ( ( -LRB- cord-006856-b1w25ob5 917 8 GvHD GvHD NNP cord-006856-b1w25ob5 917 9 ) ) -RRB- cord-006856-b1w25ob5 917 10 prophylaxis prophylaxis NN cord-006856-b1w25ob5 917 11 consisted consist VBD cord-006856-b1w25ob5 917 12 mainly mainly RB cord-006856-b1w25ob5 917 13 of of IN cord-006856-b1w25ob5 917 14 cyclosporine cyclosporine NN cord-006856-b1w25ob5 917 15 ( ( -LRB- cord-006856-b1w25ob5 917 16 CSA CSA NNP cord-006856-b1w25ob5 917 17 ) ) -RRB- cord-006856-b1w25ob5 917 18 and and CC cord-006856-b1w25ob5 917 19 methotrexate methotrexate NNP cord-006856-b1w25ob5 917 20 for for IN cord-006856-b1w25ob5 917 21 myeloablative myeloablative NNP cord-006856-b1w25ob5 917 22 and and CC cord-006856-b1w25ob5 917 23 CSA CSA NNP cord-006856-b1w25ob5 917 24 and and CC cord-006856-b1w25ob5 917 25 mycophenolate mycophenolate NNP cord-006856-b1w25ob5 917 26 mofetil mofetil NNP cord-006856-b1w25ob5 917 27 for for IN cord-006856-b1w25ob5 917 28 RIC RIC NNP cord-006856-b1w25ob5 917 29 - - HYPH cord-006856-b1w25ob5 917 30 HSCT HSCT NNP cord-006856-b1w25ob5 917 31 . . . cord-006856-b1w25ob5 918 1 Complete complete JJ cord-006856-b1w25ob5 918 2 clinical clinical JJ cord-006856-b1w25ob5 918 3 remission remission NN cord-006856-b1w25ob5 918 4 was be VBD cord-006856-b1w25ob5 918 5 attained attain VBN cord-006856-b1w25ob5 918 6 in in IN cord-006856-b1w25ob5 918 7 10 10 CD cord-006856-b1w25ob5 918 8 patients patient NNS cord-006856-b1w25ob5 918 9 ( ( -LRB- cord-006856-b1w25ob5 918 10 91 91 CD cord-006856-b1w25ob5 918 11 % % NN cord-006856-b1w25ob5 918 12 ) ) -RRB- cord-006856-b1w25ob5 918 13 after after IN cord-006856-b1w25ob5 918 14 ASCT ASCT NNP cord-006856-b1w25ob5 918 15 and and CC cord-006856-b1w25ob5 918 16 in in IN cord-006856-b1w25ob5 918 17 6 6 CD cord-006856-b1w25ob5 918 18 ( ( -LRB- cord-006856-b1w25ob5 918 19 67 67 CD cord-006856-b1w25ob5 918 20 % % NN cord-006856-b1w25ob5 918 21 ) ) -RRB- cord-006856-b1w25ob5 918 22 after after IN cord-006856-b1w25ob5 918 23 allogeneic allogeneic NN cord-006856-b1w25ob5 918 24 HSCT HSCT NNP cord-006856-b1w25ob5 918 25 . . . cord-006856-b1w25ob5 919 1 Molecular molecular JJ cord-006856-b1w25ob5 919 2 remission remission NN cord-006856-b1w25ob5 919 3 assessed assess VBN cord-006856-b1w25ob5 919 4 by by IN cord-006856-b1w25ob5 919 5 immunoglobulin immunoglobulin NN cord-006856-b1w25ob5 919 6 heavy heavy JJ cord-006856-b1w25ob5 919 7 chain chain NN cord-006856-b1w25ob5 919 8 gene gene NN cord-006856-b1w25ob5 920 1 ( ( -LRB- cord-006856-b1w25ob5 920 2 IgH IgH NNP cord-006856-b1w25ob5 920 3 ) ) -RRB- cord-006856-b1w25ob5 920 4 rearrangement rearrangement NN cord-006856-b1w25ob5 920 5 PCR PCR NNP cord-006856-b1w25ob5 920 6 was be VBD cord-006856-b1w25ob5 920 7 attained attain VBN cord-006856-b1w25ob5 920 8 in in IN cord-006856-b1w25ob5 920 9 8 8 CD cord-006856-b1w25ob5 920 10 patients patient NNS cord-006856-b1w25ob5 920 11 after after IN cord-006856-b1w25ob5 920 12 ASCT ASCT NNP cord-006856-b1w25ob5 920 13 and and CC cord-006856-b1w25ob5 920 14 5 5 CD cord-006856-b1w25ob5 920 15 after after IN cord-006856-b1w25ob5 920 16 allogeneic allogeneic NN cord-006856-b1w25ob5 920 17 HSCT HSCT NNP cord-006856-b1w25ob5 920 18 . . . cord-006856-b1w25ob5 921 1 In in IN cord-006856-b1w25ob5 921 2 seven seven CD cord-006856-b1w25ob5 921 3 patients patient NNS cord-006856-b1w25ob5 921 4 we -PRON- PRP cord-006856-b1w25ob5 921 5 noticed notice VBD cord-006856-b1w25ob5 921 6 persistence persistence NN cord-006856-b1w25ob5 921 7 of of IN cord-006856-b1w25ob5 921 8 the the DT cord-006856-b1w25ob5 921 9 IgH igh JJ cord-006856-b1w25ob5 921 10 rearrangement rearrangement NN cord-006856-b1w25ob5 921 11 , , , cord-006856-b1w25ob5 921 12 six six CD cord-006856-b1w25ob5 921 13 of of IN cord-006856-b1w25ob5 921 14 these these DT cord-006856-b1w25ob5 921 15 patients patient NNS cord-006856-b1w25ob5 921 16 died die VBD cord-006856-b1w25ob5 921 17 of of IN cord-006856-b1w25ob5 921 18 disease disease NN cord-006856-b1w25ob5 921 19 progression progression NN cord-006856-b1w25ob5 921 20 or or CC cord-006856-b1w25ob5 921 21 relapse relapse NN cord-006856-b1w25ob5 921 22 1 1 CD cord-006856-b1w25ob5 921 23 - - SYM cord-006856-b1w25ob5 921 24 29 29 CD cord-006856-b1w25ob5 921 25 months month NNS cord-006856-b1w25ob5 921 26 after after IN cord-006856-b1w25ob5 921 27 ASCT ASCT NNP cord-006856-b1w25ob5 921 28 ( ( -LRB- cord-006856-b1w25ob5 921 29 n n NN cord-006856-b1w25ob5 921 30 = = SYM cord-006856-b1w25ob5 921 31 2 2 CD cord-006856-b1w25ob5 921 32 ) ) -RRB- cord-006856-b1w25ob5 921 33 or or CC cord-006856-b1w25ob5 921 34 allogeneic allogeneic IN cord-006856-b1w25ob5 921 35 HSCT HSCT NNP cord-006856-b1w25ob5 921 36 ( ( -LRB- cord-006856-b1w25ob5 921 37 n n NN cord-006856-b1w25ob5 921 38 = = SYM cord-006856-b1w25ob5 921 39 4 4 CD cord-006856-b1w25ob5 921 40 ) ) -RRB- cord-006856-b1w25ob5 921 41 . . . cord-006856-b1w25ob5 922 1 After after IN cord-006856-b1w25ob5 922 2 a a DT cord-006856-b1w25ob5 922 3 median median JJ cord-006856-b1w25ob5 922 4 follow follow NN cord-006856-b1w25ob5 922 5 - - HYPH cord-006856-b1w25ob5 922 6 up up NN cord-006856-b1w25ob5 922 7 of of IN cord-006856-b1w25ob5 922 8 58 58 CD cord-006856-b1w25ob5 922 9 ( ( -LRB- cord-006856-b1w25ob5 922 10 range range NN cord-006856-b1w25ob5 922 11 , , , cord-006856-b1w25ob5 922 12 21 21 CD cord-006856-b1w25ob5 922 13 - - SYM cord-006856-b1w25ob5 922 14 122 122 CD cord-006856-b1w25ob5 922 15 ) ) -RRB- cord-006856-b1w25ob5 922 16 months month NNS cord-006856-b1w25ob5 922 17 , , , cord-006856-b1w25ob5 922 18 nine nine CD cord-006856-b1w25ob5 922 19 autologous autologous JJ cord-006856-b1w25ob5 922 20 ( ( -LRB- cord-006856-b1w25ob5 922 21 82 82 CD cord-006856-b1w25ob5 922 22 % % NN cord-006856-b1w25ob5 922 23 ) ) -RRB- cord-006856-b1w25ob5 922 24 and and CC cord-006856-b1w25ob5 922 25 four four CD cord-006856-b1w25ob5 922 26 allogeneic allogeneic NN cord-006856-b1w25ob5 922 27 ( ( -LRB- cord-006856-b1w25ob5 922 28 44 44 CD cord-006856-b1w25ob5 922 29 % % NN cord-006856-b1w25ob5 922 30 ) ) -RRB- cord-006856-b1w25ob5 923 1 graft graft NN cord-006856-b1w25ob5 923 2 recipients recipient NNS cord-006856-b1w25ob5 923 3 are be VBP cord-006856-b1w25ob5 923 4 alive alive JJ cord-006856-b1w25ob5 923 5 and and CC cord-006856-b1w25ob5 923 6 10 10 CD cord-006856-b1w25ob5 923 7 patients patient NNS cord-006856-b1w25ob5 923 8 ( ( -LRB- cord-006856-b1w25ob5 923 9 ASCT ASCT NNP cord-006856-b1w25ob5 923 10 , , , cord-006856-b1w25ob5 924 1 n n NN cord-006856-b1w25ob5 924 2 = = SYM cord-006856-b1w25ob5 924 3 6 6 CD cord-006856-b1w25ob5 924 4 ; ; , cord-006856-b1w25ob5 924 5 allogeneic allogeneic IN cord-006856-b1w25ob5 924 6 HSCT HSCT NNP cord-006856-b1w25ob5 924 7 , , , cord-006856-b1w25ob5 924 8 n n NN cord-006856-b1w25ob5 924 9 = = SYM cord-006856-b1w25ob5 924 10 4 4 CD cord-006856-b1w25ob5 924 11 ) ) -RRB- cord-006856-b1w25ob5 924 12 are be VBP cord-006856-b1w25ob5 924 13 in in IN cord-006856-b1w25ob5 924 14 clinical clinical JJ cord-006856-b1w25ob5 924 15 and and CC cord-006856-b1w25ob5 924 16 molecular molecular JJ cord-006856-b1w25ob5 924 17 remission remission NN cord-006856-b1w25ob5 924 18 . . . cord-006856-b1w25ob5 925 1 The the DT cord-006856-b1w25ob5 925 2 median median JJ cord-006856-b1w25ob5 925 3 time time NN cord-006856-b1w25ob5 925 4 to to IN cord-006856-b1w25ob5 925 5 clinical clinical JJ cord-006856-b1w25ob5 925 6 relapse relapse NN cord-006856-b1w25ob5 925 7 was be VBD cord-006856-b1w25ob5 925 8 20 20 CD cord-006856-b1w25ob5 926 1 ( ( -LRB- cord-006856-b1w25ob5 926 2 range range NN cord-006856-b1w25ob5 926 3 , , , cord-006856-b1w25ob5 926 4 1 1 CD cord-006856-b1w25ob5 926 5 - - SYM cord-006856-b1w25ob5 926 6 102 102 CD cord-006856-b1w25ob5 926 7 ) ) -RRB- cord-006856-b1w25ob5 926 8 months month NNS cord-006856-b1w25ob5 926 9 . . . cord-006856-b1w25ob5 927 1 Treatment treatment NN cord-006856-b1w25ob5 927 2 - - HYPH cord-006856-b1w25ob5 927 3 related relate VBN cord-006856-b1w25ob5 927 4 death death NN cord-006856-b1w25ob5 927 5 occurred occur VBD cord-006856-b1w25ob5 927 6 only only RB cord-006856-b1w25ob5 927 7 in in IN cord-006856-b1w25ob5 927 8 one one CD cord-006856-b1w25ob5 927 9 patient patient NN cord-006856-b1w25ob5 927 10 27 27 CD cord-006856-b1w25ob5 927 11 months month NNS cord-006856-b1w25ob5 927 12 after after IN cord-006856-b1w25ob5 927 13 myeloablative myeloablative NNP cord-006856-b1w25ob5 927 14 HSCT HSCT NNP cord-006856-b1w25ob5 927 15 . . . cord-006856-b1w25ob5 928 1 Probability probability NN cord-006856-b1w25ob5 928 2 of of IN cord-006856-b1w25ob5 928 3 overall overall JJ cord-006856-b1w25ob5 928 4 survival survival NN cord-006856-b1w25ob5 928 5 is be VBZ cord-006856-b1w25ob5 928 6 82 82 CD cord-006856-b1w25ob5 928 7 % % NN cord-006856-b1w25ob5 928 8 after after IN cord-006856-b1w25ob5 928 9 ASCT ASCT NNP cord-006856-b1w25ob5 928 10 and and CC cord-006856-b1w25ob5 928 11 42 42 CD cord-006856-b1w25ob5 928 12 % % NN cord-006856-b1w25ob5 928 13 after after IN cord-006856-b1w25ob5 928 14 allogeneic allogeneic NN cord-006856-b1w25ob5 928 15 HSCT HSCT NNP cord-006856-b1w25ob5 928 16 . . . cord-006856-b1w25ob5 929 1 In in IN cord-006856-b1w25ob5 929 2 summary summary NN cord-006856-b1w25ob5 929 3 , , , cord-006856-b1w25ob5 929 4 all all DT cord-006856-b1w25ob5 929 5 CLL CLL NNP cord-006856-b1w25ob5 929 6 patients patient NNS cord-006856-b1w25ob5 929 7 with with IN cord-006856-b1w25ob5 929 8 long long JJ cord-006856-b1w25ob5 929 9 - - HYPH cord-006856-b1w25ob5 929 10 term term NN cord-006856-b1w25ob5 929 11 CR cr NN cord-006856-b1w25ob5 929 12 after after IN cord-006856-b1w25ob5 929 13 ASCT ASCT NNP cord-006856-b1w25ob5 929 14 and and CC cord-006856-b1w25ob5 929 15 allogeneic allogeneic IN cord-006856-b1w25ob5 929 16 HSCT HSCT NNP cord-006856-b1w25ob5 929 17 also also RB cord-006856-b1w25ob5 929 18 attained attain VBD cord-006856-b1w25ob5 929 19 sustained sustained JJ cord-006856-b1w25ob5 929 20 molecular molecular JJ cord-006856-b1w25ob5 929 21 remission remission NN cord-006856-b1w25ob5 929 22 of of IN cord-006856-b1w25ob5 929 23 the the DT cord-006856-b1w25ob5 929 24 IgH igh JJ cord-006856-b1w25ob5 929 25 rearrangement rearrangement NN cord-006856-b1w25ob5 929 26 . . . cord-006856-b1w25ob5 929 27 . . . cord-006856-b1w25ob5 930 1 The the DT cord-006856-b1w25ob5 930 2 incidences incidence NNS cord-006856-b1w25ob5 930 3 of of IN cord-006856-b1w25ob5 930 4 the the DT cord-006856-b1w25ob5 930 5 observed observed JJ cord-006856-b1w25ob5 930 6 genotypes genotype NNS cord-006856-b1w25ob5 930 7 in in IN cord-006856-b1w25ob5 930 8 this this DT cord-006856-b1w25ob5 930 9 small small JJ cord-006856-b1w25ob5 930 10 group group NN cord-006856-b1w25ob5 930 11 of of IN cord-006856-b1w25ob5 930 12 patients patient NNS cord-006856-b1w25ob5 930 13 and and CC cord-006856-b1w25ob5 930 14 donors donor NNS cord-006856-b1w25ob5 930 15 tested test VBN cord-006856-b1w25ob5 930 16 were be VBD cord-006856-b1w25ob5 930 17 in in IN cord-006856-b1w25ob5 930 18 the the DT cord-006856-b1w25ob5 930 19 range range NN cord-006856-b1w25ob5 930 20 as as IN cord-006856-b1w25ob5 930 21 published publish VBN cord-006856-b1w25ob5 930 22 : : : cord-006856-b1w25ob5 930 23 IL10 IL10 NNP cord-006856-b1w25ob5 930 24 with with IN cord-006856-b1w25ob5 930 25 54 54 CD cord-006856-b1w25ob5 930 26 % % NN cord-006856-b1w25ob5 930 27 C c NN cord-006856-b1w25ob5 930 28 / / SYM cord-006856-b1w25ob5 930 29 C C NNP cord-006856-b1w25ob5 930 30 , , , cord-006856-b1w25ob5 930 31 41 41 CD cord-006856-b1w25ob5 930 32 % % NN cord-006856-b1w25ob5 930 33 C c NN cord-006856-b1w25ob5 930 34 / / , cord-006856-b1w25ob5 930 35 A A NNP cord-006856-b1w25ob5 930 36 , , , cord-006856-b1w25ob5 930 37 5 5 CD cord-006856-b1w25ob5 930 38 % % NN cord-006856-b1w25ob5 931 1 A a LS cord-006856-b1w25ob5 931 2 / / SYM cord-006856-b1w25ob5 931 3 A a NN cord-006856-b1w25ob5 931 4 ; ; : cord-006856-b1w25ob5 931 5 NOD2 NOD2 NNPS cord-006856-b1w25ob5 931 6 with with IN cord-006856-b1w25ob5 931 7 12 12 CD cord-006856-b1w25ob5 931 8 % % NN cord-006856-b1w25ob5 931 9 recipient recipient NN cord-006856-b1w25ob5 931 10 or or CC cord-006856-b1w25ob5 931 11 donor donor NN cord-006856-b1w25ob5 931 12 ; ; : cord-006856-b1w25ob5 931 13 5 5 CD cord-006856-b1w25ob5 931 14 % % NN cord-006856-b1w25ob5 931 15 recipient recipient NN cord-006856-b1w25ob5 931 16 and and CC cord-006856-b1w25ob5 931 17 donor donor NN cord-006856-b1w25ob5 931 18 , , , cord-006856-b1w25ob5 931 19 and and CC cord-006856-b1w25ob5 931 20 MPO MPO NNP cord-006856-b1w25ob5 931 21 with with IN cord-006856-b1w25ob5 931 22 56 56 CD cord-006856-b1w25ob5 931 23 % % NN cord-006856-b1w25ob5 931 24 G g NN cord-006856-b1w25ob5 931 25 / / SYM cord-006856-b1w25ob5 931 26 G g NN cord-006856-b1w25ob5 931 27 , , , cord-006856-b1w25ob5 931 28 43 43 CD cord-006856-b1w25ob5 931 29 % % NN cord-006856-b1w25ob5 931 30 G g NN cord-006856-b1w25ob5 931 31 / / SYM cord-006856-b1w25ob5 931 32 A A NNP cord-006856-b1w25ob5 931 33 , , , cord-006856-b1w25ob5 931 34 1 1 CD cord-006856-b1w25ob5 931 35 % % NN cord-006856-b1w25ob5 931 36 A a NN cord-006856-b1w25ob5 931 37 / / SYM cord-006856-b1w25ob5 931 38 A. a. NN cord-006856-b1w25ob5 932 1 Since since IN cord-006856-b1w25ob5 932 2 the the DT cord-006856-b1w25ob5 932 3 patient patient JJ cord-006856-b1w25ob5 932 4 population population NN cord-006856-b1w25ob5 932 5 was be VBD cord-006856-b1w25ob5 932 6 very very RB cord-006856-b1w25ob5 932 7 heterogeneous heterogeneous JJ cord-006856-b1w25ob5 932 8 concerning concern VBG cord-006856-b1w25ob5 932 9 diagnosis diagnosis NN cord-006856-b1w25ob5 932 10 ( ( -LRB- cord-006856-b1w25ob5 932 11 34 34 CD cord-006856-b1w25ob5 932 12 AML AML NNP cord-006856-b1w25ob5 932 13 , , , cord-006856-b1w25ob5 932 14 12 12 CD cord-006856-b1w25ob5 932 15 ALL all DT cord-006856-b1w25ob5 932 16 , , , cord-006856-b1w25ob5 932 17 9 9 CD cord-006856-b1w25ob5 932 18 NHL NHL NNP cord-006856-b1w25ob5 932 19 , , , cord-006856-b1w25ob5 932 20 6 6 CD cord-006856-b1w25ob5 932 21 CML CML NNP cord-006856-b1w25ob5 932 22 , , , cord-006856-b1w25ob5 932 23 5 5 CD cord-006856-b1w25ob5 932 24 MDS MDS NNP cord-006856-b1w25ob5 932 25 , , , cord-006856-b1w25ob5 932 26 4 4 CD cord-006856-b1w25ob5 932 27 SAA SAA NNP cord-006856-b1w25ob5 932 28 , , , cord-006856-b1w25ob5 932 29 4 4 CD cord-006856-b1w25ob5 932 30 solid solid JJ cord-006856-b1w25ob5 932 31 tumors tumor NNS cord-006856-b1w25ob5 932 32 , , , cord-006856-b1w25ob5 932 33 3 3 CD cord-006856-b1w25ob5 932 34 MM MM NNP cord-006856-b1w25ob5 932 35 , , , cord-006856-b1w25ob5 932 36 2 2 CD cord-006856-b1w25ob5 932 37 OMF omf NN cord-006856-b1w25ob5 932 38 , , , cord-006856-b1w25ob5 932 39 1 1 CD cord-006856-b1w25ob5 932 40 CLL CLL NNP cord-006856-b1w25ob5 932 41 , , , cord-006856-b1w25ob5 932 42 and and CC cord-006856-b1w25ob5 932 43 1 1 CD cord-006856-b1w25ob5 932 44 ET ET NNP cord-006856-b1w25ob5 932 45 ) ) -RRB- cord-006856-b1w25ob5 932 46 , , , cord-006856-b1w25ob5 932 47 course course NN cord-006856-b1w25ob5 932 48 of of IN cord-006856-b1w25ob5 932 49 disease disease NN cord-006856-b1w25ob5 932 50 , , , cord-006856-b1w25ob5 932 51 and and CC cord-006856-b1w25ob5 932 52 condition condition NN cord-006856-b1w25ob5 932 53 regimen regimen NN cord-006856-b1w25ob5 932 54 , , , cord-006856-b1w25ob5 932 55 patients patient NNS cord-006856-b1w25ob5 932 56 were be VBD cord-006856-b1w25ob5 932 57 divided divide VBN cord-006856-b1w25ob5 932 58 into into IN cord-006856-b1w25ob5 932 59 four four CD cord-006856-b1w25ob5 932 60 groups group NNS cord-006856-b1w25ob5 932 61 for for IN cord-006856-b1w25ob5 932 62 evaluation evaluation NN cord-006856-b1w25ob5 932 63 : : : cord-006856-b1w25ob5 932 64 23 23 CD cord-006856-b1w25ob5 932 65 with with IN cord-006856-b1w25ob5 932 66 AML AML NNP cord-006856-b1w25ob5 932 67 and and CC cord-006856-b1w25ob5 932 68 identical identical JJ cord-006856-b1w25ob5 932 69 high high JJ cord-006856-b1w25ob5 932 70 - - HYPH cord-006856-b1w25ob5 932 71 dose dose NN cord-006856-b1w25ob5 932 72 induction induction NN cord-006856-b1w25ob5 932 73 therapy therapy NN cord-006856-b1w25ob5 932 74 ( ( -LRB- cord-006856-b1w25ob5 932 75 BU BU NNP cord-006856-b1w25ob5 932 76 / / SYM cord-006856-b1w25ob5 932 77 CY CY NNP cord-006856-b1w25ob5 932 78 ) ) -RRB- cord-006856-b1w25ob5 932 79 , , , cord-006856-b1w25ob5 932 80 23 23 CD cord-006856-b1w25ob5 932 81 with with IN cord-006856-b1w25ob5 932 82 reduced reduce VBN cord-006856-b1w25ob5 932 83 condition condition NN cord-006856-b1w25ob5 932 84 regimen regimen NN cord-006856-b1w25ob5 932 85 , , , cord-006856-b1w25ob5 932 86 6 6 CD cord-006856-b1w25ob5 932 87 with with IN cord-006856-b1w25ob5 932 88 unrelated unrelated JJ cord-006856-b1w25ob5 932 89 donors donor NNS cord-006856-b1w25ob5 932 90 , , , cord-006856-b1w25ob5 932 91 and and CC cord-006856-b1w25ob5 932 92 29 29 CD cord-006856-b1w25ob5 932 93 others other NNS cord-006856-b1w25ob5 932 94 . . . cord-006856-b1w25ob5 933 1 Concerning concern VBG cord-006856-b1w25ob5 933 2 all all DT cord-006856-b1w25ob5 933 3 81 81 CD cord-006856-b1w25ob5 933 4 patients patient NNS cord-006856-b1w25ob5 933 5 , , , cord-006856-b1w25ob5 933 6 19 19 CD cord-006856-b1w25ob5 933 7 of of IN cord-006856-b1w25ob5 933 8 them -PRON- PRP cord-006856-b1w25ob5 933 9 ( ( -LRB- cord-006856-b1w25ob5 933 10 23 23 CD cord-006856-b1w25ob5 933 11 % % NN cord-006856-b1w25ob5 933 12 ) ) -RRB- cord-006856-b1w25ob5 933 13 died die VBD cord-006856-b1w25ob5 933 14 through through IN cord-006856-b1w25ob5 933 15 TRM TRM NNP cord-006856-b1w25ob5 933 16 ( ( -LRB- cord-006856-b1w25ob5 933 17 3 3 CD cord-006856-b1w25ob5 933 18 AML AML NNP cord-006856-b1w25ob5 933 19 , , , cord-006856-b1w25ob5 933 20 6 6 CD cord-006856-b1w25ob5 933 21 reduced reduce VBN cord-006856-b1w25ob5 933 22 , , , cord-006856-b1w25ob5 933 23 10 10 CD cord-006856-b1w25ob5 933 24 others other NNS cord-006856-b1w25ob5 933 25 ) ) -RRB- cord-006856-b1w25ob5 933 26 , , , cord-006856-b1w25ob5 933 27 but but CC cord-006856-b1w25ob5 933 28 none none NN cord-006856-b1w25ob5 933 29 of of IN cord-006856-b1w25ob5 933 30 them -PRON- PRP cord-006856-b1w25ob5 933 31 was be VBD cord-006856-b1w25ob5 933 32 at at IN cord-006856-b1w25ob5 933 33 high high JJ cord-006856-b1w25ob5 933 34 risk risk NN cord-006856-b1w25ob5 933 35 determined determine VBN cord-006856-b1w25ob5 933 36 by by IN cord-006856-b1w25ob5 933 37 NOD2 NOD2 NNP cord-006856-b1w25ob5 933 38 polymorphism polymorphism NN cord-006856-b1w25ob5 933 39 ( ( -LRB- cord-006856-b1w25ob5 933 40 mutated mutate VBN cord-006856-b1w25ob5 933 41 donor donor NN cord-006856-b1w25ob5 933 42 and and CC cord-006856-b1w25ob5 933 43 recipient recipient NN cord-006856-b1w25ob5 933 44 ) ) -RRB- cord-006856-b1w25ob5 933 45 and and CC cord-006856-b1w25ob5 933 46 only only RB cord-006856-b1w25ob5 933 47 one one CD cord-006856-b1w25ob5 933 48 determined determine VBN cord-006856-b1w25ob5 933 49 by by IN cord-006856-b1w25ob5 934 1 MPO MPO NNP cord-006856-b1w25ob5 934 2 A A NNP cord-006856-b1w25ob5 934 3 / / SYM cord-006856-b1w25ob5 934 4 A a DT cord-006856-b1w25ob5 934 5 genotype genotype NN cord-006856-b1w25ob5 934 6 ( ( -LRB- cord-006856-b1w25ob5 934 7 AML AML NNP cord-006856-b1w25ob5 934 8 ) ) -RRB- cord-006856-b1w25ob5 934 9 . . . cord-006856-b1w25ob5 935 1 Four four CD cord-006856-b1w25ob5 935 2 patients patient NNS cord-006856-b1w25ob5 935 3 ( ( -LRB- cord-006856-b1w25ob5 935 4 3 3 CD cord-006856-b1w25ob5 935 5 reduced reduce VBN cord-006856-b1w25ob5 935 6 , , , cord-006856-b1w25ob5 935 7 1 1 CD cord-006856-b1w25ob5 935 8 others other NNS cord-006856-b1w25ob5 935 9 ) ) -RRB- cord-006856-b1w25ob5 935 10 with with IN cord-006856-b1w25ob5 935 11 NOD2 NOD2 NNP cord-006856-b1w25ob5 935 12 mutations mutation NNS cord-006856-b1w25ob5 935 13 in in IN cord-006856-b1w25ob5 935 14 donor donor NN cord-006856-b1w25ob5 935 15 and and CC cord-006856-b1w25ob5 935 16 recipient recipient NN cord-006856-b1w25ob5 935 17 DNA DNA NNP cord-006856-b1w25ob5 935 18 did do VBD cord-006856-b1w25ob5 935 19 not not RB cord-006856-b1w25ob5 935 20 die die VB cord-006856-b1w25ob5 935 21 from from IN cord-006856-b1w25ob5 935 22 TRM TRM NNP cord-006856-b1w25ob5 935 23 . . . cord-006856-b1w25ob5 936 1 Twenty twenty CD cord-006856-b1w25ob5 936 2 - - HYPH cord-006856-b1w25ob5 936 3 three three CD cord-006856-b1w25ob5 936 4 patients patient NNS cord-006856-b1w25ob5 936 5 developed develop VBD cord-006856-b1w25ob5 936 6 severe severe JJ cord-006856-b1w25ob5 936 7 ( ( -LRB- cord-006856-b1w25ob5 936 8 grade grade NN cord-006856-b1w25ob5 936 9 3 3 CD cord-006856-b1w25ob5 936 10 or or CC cord-006856-b1w25ob5 936 11 4 4 CD cord-006856-b1w25ob5 936 12 ) ) -RRB- cord-006856-b1w25ob5 936 13 acute acute JJ cord-006856-b1w25ob5 936 14 GvHD GvHD NNP cord-006856-b1w25ob5 936 15 ( ( -LRB- cord-006856-b1w25ob5 936 16 7 7 CD cord-006856-b1w25ob5 936 17 AML AML NNP cord-006856-b1w25ob5 936 18 , , , cord-006856-b1w25ob5 936 19 5 5 CD cord-006856-b1w25ob5 936 20 reduced reduce VBN cord-006856-b1w25ob5 936 21 , , , cord-006856-b1w25ob5 936 22 11 11 CD cord-006856-b1w25ob5 936 23 others other NNS cord-006856-b1w25ob5 936 24 ) ) -RRB- cord-006856-b1w25ob5 936 25 , , , cord-006856-b1w25ob5 936 26 10 10 CD cord-006856-b1w25ob5 936 27 of of IN cord-006856-b1w25ob5 936 28 them -PRON- PRP cord-006856-b1w25ob5 936 29 had have VBD cord-006856-b1w25ob5 936 30 IL10 IL10 NNP cord-006856-b1w25ob5 936 31 C C NNP cord-006856-b1w25ob5 936 32 / / SYM cord-006856-b1w25ob5 936 33 C c NN cord-006856-b1w25ob5 936 34 genotype genotype NN cord-006856-b1w25ob5 936 35 ( ( -LRB- cord-006856-b1w25ob5 936 36 5 5 CD cord-006856-b1w25ob5 936 37 AML AML NNP cord-006856-b1w25ob5 936 38 , , , cord-006856-b1w25ob5 937 1 2 2 CD cord-006856-b1w25ob5 937 2 reduced reduce VBN cord-006856-b1w25ob5 937 3 , , , cord-006856-b1w25ob5 937 4 3 3 CD cord-006856-b1w25ob5 937 5 others other NNS cord-006856-b1w25ob5 937 6 ) ) -RRB- cord-006856-b1w25ob5 937 7 and and CC cord-006856-b1w25ob5 937 8 in in IN cord-006856-b1w25ob5 937 9 three three CD cord-006856-b1w25ob5 937 10 patients patient NNS cord-006856-b1w25ob5 937 11 NOD2 NOD2 NNP cord-006856-b1w25ob5 937 12 was be VBD cord-006856-b1w25ob5 937 13 mutated mutate VBN cord-006856-b1w25ob5 937 14 in in IN cord-006856-b1w25ob5 937 15 donor donor NN cord-006856-b1w25ob5 937 16 and/or and/or CC cord-006856-b1w25ob5 937 17 recipient recipient NN cord-006856-b1w25ob5 937 18 DNA dna NN cord-006856-b1w25ob5 937 19 ( ( -LRB- cord-006856-b1w25ob5 937 20 1 1 CD cord-006856-b1w25ob5 937 21 AML AML NNP cord-006856-b1w25ob5 937 22 , , , cord-006856-b1w25ob5 937 23 2 2 CD cord-006856-b1w25ob5 937 24 others other NNS cord-006856-b1w25ob5 937 25 ) ) -RRB- cord-006856-b1w25ob5 937 26 . . . cord-006856-b1w25ob5 938 1 On on IN cord-006856-b1w25ob5 938 2 the the DT cord-006856-b1w25ob5 938 3 other other JJ cord-006856-b1w25ob5 938 4 hand hand NN cord-006856-b1w25ob5 938 5 , , , cord-006856-b1w25ob5 938 6 34 34 CD cord-006856-b1w25ob5 938 7 patients patient NNS cord-006856-b1w25ob5 938 8 with with IN cord-006856-b1w25ob5 938 9 IL10 IL10 NNP cord-006856-b1w25ob5 938 10 C C NNP cord-006856-b1w25ob5 938 11 / / SYM cord-006856-b1w25ob5 938 12 C C NNP cord-006856-b1w25ob5 938 13 genotype genotype NN cord-006856-b1w25ob5 938 14 and and CC cord-006856-b1w25ob5 938 15 13 13 CD cord-006856-b1w25ob5 938 16 patients patient NNS cord-006856-b1w25ob5 938 17 with with IN cord-006856-b1w25ob5 938 18 NOD2 NOD2 NNP cord-006856-b1w25ob5 938 19 mutations mutation NNS cord-006856-b1w25ob5 938 20 in in IN cord-006856-b1w25ob5 938 21 donor donor NN cord-006856-b1w25ob5 938 22 and/or and/or CC cord-006856-b1w25ob5 938 23 recipient recipient NN cord-006856-b1w25ob5 938 24 DNA dna NN cord-006856-b1w25ob5 938 25 developed develop VBD cord-006856-b1w25ob5 938 26 no no DT cord-006856-b1w25ob5 938 27 or or CC cord-006856-b1w25ob5 938 28 mild mild JJ cord-006856-b1w25ob5 938 29 GvHD gvhd NN cord-006856-b1w25ob5 938 30 only only RB cord-006856-b1w25ob5 938 31 . . . cord-006856-b1w25ob5 939 1 In in IN cord-006856-b1w25ob5 939 2 conclusion conclusion NN cord-006856-b1w25ob5 939 3 , , , cord-006856-b1w25ob5 939 4 so so RB cord-006856-b1w25ob5 939 5 far far RB cord-006856-b1w25ob5 939 6 we -PRON- PRP cord-006856-b1w25ob5 939 7 were be VBD cord-006856-b1w25ob5 939 8 not not RB cord-006856-b1w25ob5 939 9 able able JJ cord-006856-b1w25ob5 939 10 to to TO cord-006856-b1w25ob5 939 11 find find VB cord-006856-b1w25ob5 939 12 a a DT cord-006856-b1w25ob5 939 13 correlation correlation NN cord-006856-b1w25ob5 939 14 between between IN cord-006856-b1w25ob5 939 15 GvHD GvHD NNP cord-006856-b1w25ob5 939 16 / / SYM cord-006856-b1w25ob5 939 17 TRM TRM NNP cord-006856-b1w25ob5 939 18 risks risk NNS cord-006856-b1w25ob5 939 19 and and CC cord-006856-b1w25ob5 939 20 polymorphisms polymorphism NNS cord-006856-b1w25ob5 939 21 of of IN cord-006856-b1w25ob5 939 22 IL10 IL10 NNP cord-006856-b1w25ob5 939 23 , , , cord-006856-b1w25ob5 939 24 NOD2 NOD2 NNPS cord-006856-b1w25ob5 939 25 , , , cord-006856-b1w25ob5 939 26 and and CC cord-006856-b1w25ob5 939 27 MPO MPO NNP cord-006856-b1w25ob5 939 28 . . . cord-006856-b1w25ob5 940 1 This this DT cord-006856-b1w25ob5 940 2 might may MD cord-006856-b1w25ob5 940 3 be be VB cord-006856-b1w25ob5 940 4 due due JJ cord-006856-b1w25ob5 940 5 to to IN cord-006856-b1w25ob5 940 6 the the DT cord-006856-b1w25ob5 940 7 small small JJ cord-006856-b1w25ob5 940 8 number number NN cord-006856-b1w25ob5 940 9 and and CC cord-006856-b1w25ob5 940 10 the the DT cord-006856-b1w25ob5 940 11 heterogeneity heterogeneity NN cord-006856-b1w25ob5 940 12 of of IN cord-006856-b1w25ob5 940 13 the the DT cord-006856-b1w25ob5 940 14 patients patient NNS cord-006856-b1w25ob5 940 15 ; ; : cord-006856-b1w25ob5 940 16 however however RB cord-006856-b1w25ob5 940 17 , , , cord-006856-b1w25ob5 940 18 a a DT cord-006856-b1w25ob5 940 19 panel panel NN cord-006856-b1w25ob5 940 20 of of IN cord-006856-b1w25ob5 940 21 additional additional JJ cord-006856-b1w25ob5 940 22 SNPs snp NNS cord-006856-b1w25ob5 940 23 may may MD cord-006856-b1w25ob5 940 24 increase increase VB cord-006856-b1w25ob5 940 25 the the DT cord-006856-b1w25ob5 940 26 accuracy accuracy NN cord-006856-b1w25ob5 940 27 of of IN cord-006856-b1w25ob5 940 28 risk risk NN cord-006856-b1w25ob5 940 29 assessment assessment NN cord-006856-b1w25ob5 940 30 prior prior RB cord-006856-b1w25ob5 940 31 to to IN cord-006856-b1w25ob5 940 32 allogeneic allogeneic NN cord-006856-b1w25ob5 940 33 SCT SCT NNP cord-006856-b1w25ob5 940 34 . . . cord-006856-b1w25ob5 941 1 Background background NN cord-006856-b1w25ob5 941 2 . . . cord-006856-b1w25ob5 942 1 Allogeneic allogeneic IN cord-006856-b1w25ob5 942 2 stem stem VBP cord-006856-b1w25ob5 942 3 cell cell NN cord-006856-b1w25ob5 942 4 transplantation transplantation NN cord-006856-b1w25ob5 942 5 is be VBZ cord-006856-b1w25ob5 942 6 a a DT cord-006856-b1w25ob5 942 7 curative curative JJ cord-006856-b1w25ob5 942 8 therapy therapy NN cord-006856-b1w25ob5 942 9 for for IN cord-006856-b1w25ob5 942 10 patients patient NNS cord-006856-b1w25ob5 942 11 with with IN cord-006856-b1w25ob5 942 12 lymphoproliferative lymphoproliferative JJ cord-006856-b1w25ob5 942 13 disorders disorder NNS cord-006856-b1w25ob5 942 14 as as IN cord-006856-b1w25ob5 942 15 a a DT cord-006856-b1w25ob5 942 16 result result NN cord-006856-b1w25ob5 942 17 of of IN cord-006856-b1w25ob5 942 18 the the DT cord-006856-b1w25ob5 942 19 intensity intensity NN cord-006856-b1w25ob5 942 20 of of IN cord-006856-b1w25ob5 942 21 the the DT cord-006856-b1w25ob5 942 22 conditioning conditioning NN cord-006856-b1w25ob5 942 23 regimen regimen NN cord-006856-b1w25ob5 942 24 and and CC cord-006856-b1w25ob5 942 25 the the DT cord-006856-b1w25ob5 942 26 application application NN cord-006856-b1w25ob5 942 27 of of IN cord-006856-b1w25ob5 942 28 a a DT cord-006856-b1w25ob5 942 29 graft graft NN cord-006856-b1w25ob5 942 30 - - HYPH cord-006856-b1w25ob5 942 31 versus versus IN cord-006856-b1w25ob5 942 32 - - HYPH cord-006856-b1w25ob5 942 33 lymphoma lymphoma NN cord-006856-b1w25ob5 942 34 effect effect NN cord-006856-b1w25ob5 942 35 . . . cord-006856-b1w25ob5 943 1 However however RB cord-006856-b1w25ob5 943 2 , , , cord-006856-b1w25ob5 943 3 conventional conventional JJ cord-006856-b1w25ob5 943 4 conditioning conditioning NN cord-006856-b1w25ob5 943 5 regimens regimen NNS cord-006856-b1w25ob5 943 6 have have VBP cord-006856-b1w25ob5 943 7 been be VBN cord-006856-b1w25ob5 943 8 associated associate VBN cord-006856-b1w25ob5 943 9 with with IN cord-006856-b1w25ob5 943 10 a a DT cord-006856-b1w25ob5 943 11 24 24 CD cord-006856-b1w25ob5 943 12 - - SYM cord-006856-b1w25ob5 943 13 61 61 CD cord-006856-b1w25ob5 943 14 % % NN cord-006856-b1w25ob5 943 15 risk risk NN cord-006856-b1w25ob5 943 16 of of IN cord-006856-b1w25ob5 943 17 transplant transplant NN cord-006856-b1w25ob5 943 18 - - HYPH cord-006856-b1w25ob5 943 19 related relate VBN cord-006856-b1w25ob5 943 20 mortality mortality NN cord-006856-b1w25ob5 943 21 ( ( -LRB- cord-006856-b1w25ob5 943 22 TRM TRM NNP cord-006856-b1w25ob5 943 23 ) ) -RRB- cord-006856-b1w25ob5 943 24 in in IN cord-006856-b1w25ob5 943 25 advanced advanced JJ cord-006856-b1w25ob5 943 26 Hodgkin Hodgkin NNP cord-006856-b1w25ob5 943 27 's 's POS cord-006856-b1w25ob5 943 28 lymphoma lymphoma NN cord-006856-b1w25ob5 943 29 ( ( -LRB- cord-006856-b1w25ob5 943 30 HL HL NNP cord-006856-b1w25ob5 943 31 ) ) -RRB- cord-006856-b1w25ob5 943 32 . . . cord-006856-b1w25ob5 944 1 In in IN cord-006856-b1w25ob5 944 2 an an DT cord-006856-b1w25ob5 944 3 attempt attempt NN cord-006856-b1w25ob5 944 4 to to TO cord-006856-b1w25ob5 944 5 reduce reduce VB cord-006856-b1w25ob5 944 6 the the DT cord-006856-b1w25ob5 944 7 high high JJ cord-006856-b1w25ob5 944 8 TRM TRM NNP cord-006856-b1w25ob5 944 9 reported report VBN cord-006856-b1w25ob5 944 10 with with IN cord-006856-b1w25ob5 944 11 allografting allografte VBG cord-006856-b1w25ob5 944 12 in in IN cord-006856-b1w25ob5 944 13 lymphoma lymphoma NN cord-006856-b1w25ob5 944 14 , , , cord-006856-b1w25ob5 944 15 reduced reduce VBN cord-006856-b1w25ob5 944 16 - - HYPH cord-006856-b1w25ob5 944 17 intensity intensity NN cord-006856-b1w25ob5 944 18 regimens regimen NNS cord-006856-b1w25ob5 944 19 have have VBP cord-006856-b1w25ob5 944 20 been be VBN cord-006856-b1w25ob5 944 21 investigated investigate VBN cord-006856-b1w25ob5 944 22 . . . cord-006856-b1w25ob5 945 1 Methods method NNS cord-006856-b1w25ob5 945 2 . . . cord-006856-b1w25ob5 946 1 Four four CD cord-006856-b1w25ob5 946 2 patients patient NNS cord-006856-b1w25ob5 946 3 between between IN cord-006856-b1w25ob5 946 4 the the DT cord-006856-b1w25ob5 946 5 age age NN cord-006856-b1w25ob5 946 6 of of IN cord-006856-b1w25ob5 946 7 34 34 CD cord-006856-b1w25ob5 946 8 and and CC cord-006856-b1w25ob5 946 9 44 44 CD cord-006856-b1w25ob5 946 10 years year NNS cord-006856-b1w25ob5 946 11 underwent undergo VBD cord-006856-b1w25ob5 946 12 allogeneic allogeneic IN cord-006856-b1w25ob5 946 13 peripheral peripheral JJ cord-006856-b1w25ob5 946 14 blood blood NN cord-006856-b1w25ob5 946 15 stem stem NN cord-006856-b1w25ob5 946 16 cell cell NN cord-006856-b1w25ob5 946 17 ( ( -LRB- cord-006856-b1w25ob5 946 18 PBSC PBSC NNP cord-006856-b1w25ob5 946 19 ) ) -RRB- cord-006856-b1w25ob5 946 20 transplantation transplantation NN cord-006856-b1w25ob5 946 21 ( ( -LRB- cord-006856-b1w25ob5 946 22 SCT SCT NNP cord-006856-b1w25ob5 946 23 ) ) -RRB- cord-006856-b1w25ob5 946 24 from from IN cord-006856-b1w25ob5 946 25 HLA HLA NNP cord-006856-b1w25ob5 946 26 - - HYPH cord-006856-b1w25ob5 946 27 identical identical JJ cord-006856-b1w25ob5 946 28 sibling sibling NN cord-006856-b1w25ob5 946 29 or or CC cord-006856-b1w25ob5 946 30 unrelated unrelated JJ cord-006856-b1w25ob5 946 31 donors donor NNS cord-006856-b1w25ob5 946 32 at at IN cord-006856-b1w25ob5 946 33 our -PRON- PRP$ cord-006856-b1w25ob5 946 34 institution institution NN cord-006856-b1w25ob5 946 35 . . . cord-006856-b1w25ob5 947 1 Age age NN cord-006856-b1w25ob5 947 2 , , , cord-006856-b1w25ob5 947 3 sex sex NN cord-006856-b1w25ob5 947 4 , , , cord-006856-b1w25ob5 947 5 manifestation manifestation NN cord-006856-b1w25ob5 947 6 of of IN cord-006856-b1w25ob5 947 7 disease disease NN cord-006856-b1w25ob5 947 8 , , , cord-006856-b1w25ob5 947 9 and and CC cord-006856-b1w25ob5 947 10 donor donor NN cord-006856-b1w25ob5 947 11 were be VBD cord-006856-b1w25ob5 947 12 as as IN cord-006856-b1w25ob5 947 13 follows follow VBZ cord-006856-b1w25ob5 947 14 : : : cord-006856-b1w25ob5 947 15 patient patient JJ cord-006856-b1w25ob5 947 16 1 1 CD cord-006856-b1w25ob5 947 17 - - SYM cord-006856-b1w25ob5 947 18 37 37 CD cord-006856-b1w25ob5 947 19 years year NNS cord-006856-b1w25ob5 947 20 , , , cord-006856-b1w25ob5 947 21 female female JJ cord-006856-b1w25ob5 947 22 , , , cord-006856-b1w25ob5 947 23 pulmonary pulmonary JJ cord-006856-b1w25ob5 947 24 bulk bulk NN cord-006856-b1w25ob5 947 25 , , , cord-006856-b1w25ob5 947 26 sibling sibling NN cord-006856-b1w25ob5 947 27 ; ; : cord-006856-b1w25ob5 947 28 patient patient JJ cord-006856-b1w25ob5 947 29 2 2 CD cord-006856-b1w25ob5 947 30 - - SYM cord-006856-b1w25ob5 947 31 34 34 CD cord-006856-b1w25ob5 947 32 years year NNS cord-006856-b1w25ob5 947 33 , , , cord-006856-b1w25ob5 947 34 male male JJ cord-006856-b1w25ob5 947 35 , , , cord-006856-b1w25ob5 947 36 pulmonary pulmonary JJ cord-006856-b1w25ob5 947 37 bulk bulk NN cord-006856-b1w25ob5 947 38 , , , cord-006856-b1w25ob5 947 39 unrelated unrelated JJ cord-006856-b1w25ob5 947 40 donor donor NN cord-006856-b1w25ob5 947 41 ; ; : cord-006856-b1w25ob5 947 42 patient patient JJ cord-006856-b1w25ob5 947 43 3 3 CD cord-006856-b1w25ob5 947 44 - - SYM cord-006856-b1w25ob5 947 45 42 42 CD cord-006856-b1w25ob5 947 46 years year NNS cord-006856-b1w25ob5 947 47 , , , cord-006856-b1w25ob5 947 48 male male JJ cord-006856-b1w25ob5 947 49 , , , cord-006856-b1w25ob5 947 50 pulmonary pulmonary JJ cord-006856-b1w25ob5 947 51 bulk bulk NN cord-006856-b1w25ob5 947 52 , , , cord-006856-b1w25ob5 947 53 sibling sibling NN cord-006856-b1w25ob5 947 54 ; ; : cord-006856-b1w25ob5 947 55 patient patient JJ cord-006856-b1w25ob5 947 56 4 4 CD cord-006856-b1w25ob5 947 57 - - SYM cord-006856-b1w25ob5 947 58 44 44 CD cord-006856-b1w25ob5 947 59 years year NNS cord-006856-b1w25ob5 947 60 , , , cord-006856-b1w25ob5 947 61 male male JJ cord-006856-b1w25ob5 947 62 , , , cord-006856-b1w25ob5 947 63 abdominal abdominal JJ cord-006856-b1w25ob5 947 64 bulk bulk NN cord-006856-b1w25ob5 947 65 , , , cord-006856-b1w25ob5 947 66 sibling sibling NN cord-006856-b1w25ob5 947 67 . . . cord-006856-b1w25ob5 948 1 All all DT cord-006856-b1w25ob5 948 2 patients patient NNS cord-006856-b1w25ob5 948 3 had have VBD cord-006856-b1w25ob5 948 4 received receive VBN cord-006856-b1w25ob5 948 5 multiple multiple JJ cord-006856-b1w25ob5 948 6 courses course NNS cord-006856-b1w25ob5 948 7 of of IN cord-006856-b1w25ob5 948 8 polychemotherapy polychemotherapy FW cord-006856-b1w25ob5 948 9 ( ( -LRB- cord-006856-b1w25ob5 948 10 Table Table NNP cord-006856-b1w25ob5 948 11 1 1 CD cord-006856-b1w25ob5 948 12 ) ) -RRB- cord-006856-b1w25ob5 948 13 and and CC cord-006856-b1w25ob5 948 14 local local JJ cord-006856-b1w25ob5 948 15 radiotherapy radiotherapy NN cord-006856-b1w25ob5 948 16 prior prior RB cord-006856-b1w25ob5 948 17 to to IN cord-006856-b1w25ob5 948 18 SCT SCT NNP cord-006856-b1w25ob5 948 19 . . . cord-006856-b1w25ob5 949 1 Patients patient NNS cord-006856-b1w25ob5 949 2 1 1 CD cord-006856-b1w25ob5 949 3 and and CC cord-006856-b1w25ob5 949 4 4 4 CD cord-006856-b1w25ob5 949 5 had have VBD cord-006856-b1w25ob5 949 6 undergone undergo VBN cord-006856-b1w25ob5 949 7 autologous autologous JJ cord-006856-b1w25ob5 949 8 stem stem NN cord-006856-b1w25ob5 949 9 cell cell NN cord-006856-b1w25ob5 949 10 transplantation transplantation NN cord-006856-b1w25ob5 949 11 . . . cord-006856-b1w25ob5 950 1 We -PRON- PRP cord-006856-b1w25ob5 950 2 administered administer VBD cord-006856-b1w25ob5 950 3 a a DT cord-006856-b1w25ob5 950 4 reduced reduce VBN cord-006856-b1w25ob5 950 5 - - HYPH cord-006856-b1w25ob5 950 6 intensity intensity NN cord-006856-b1w25ob5 950 7 conditioning conditioning NN cord-006856-b1w25ob5 950 8 consisting consist VBG cord-006856-b1w25ob5 950 9 of of IN cord-006856-b1w25ob5 950 10 BEAM BEAM NNP cord-006856-b1w25ob5 950 11 ( ( -LRB- cord-006856-b1w25ob5 950 12 BCNU BCNU NNP cord-006856-b1w25ob5 950 13 , , , cord-006856-b1w25ob5 950 14 etoposide etoposide RB cord-006856-b1w25ob5 950 15 , , , cord-006856-b1w25ob5 950 16 cytarabine cytarabine NNP cord-006856-b1w25ob5 950 17 and and CC cord-006856-b1w25ob5 950 18 melphalan melphalan NNP cord-006856-b1w25ob5 950 19 ) ) -RRB- cord-006856-b1w25ob5 950 20 over over IN cord-006856-b1w25ob5 950 21 6 6 CD cord-006856-b1w25ob5 950 22 days day NNS cord-006856-b1w25ob5 950 23 . . . cord-006856-b1w25ob5 951 1 To to TO cord-006856-b1w25ob5 951 2 permit permit VB cord-006856-b1w25ob5 951 3 durable durable JJ cord-006856-b1w25ob5 951 4 engraftment engraftment NN cord-006856-b1w25ob5 951 5 in in IN cord-006856-b1w25ob5 951 6 the the DT cord-006856-b1w25ob5 951 7 allogeneic allogeneic NN cord-006856-b1w25ob5 951 8 setting setting NN cord-006856-b1w25ob5 951 9 , , , cord-006856-b1w25ob5 951 10 patients patient NNS cord-006856-b1w25ob5 951 11 received receive VBD cord-006856-b1w25ob5 951 12 additional additional JJ cord-006856-b1w25ob5 951 13 pretransplant pretransplant JJ cord-006856-b1w25ob5 951 14 immunosuppression immunosuppression NN cord-006856-b1w25ob5 951 15 with with IN cord-006856-b1w25ob5 951 16 an an DT cord-006856-b1w25ob5 951 17 anti anti JJ cord-006856-b1w25ob5 951 18 - - JJ cord-006856-b1w25ob5 951 19 CD52 cd52 JJ cord-006856-b1w25ob5 951 20 antibody antibody NN cord-006856-b1w25ob5 951 21 ( ( -LRB- cord-006856-b1w25ob5 951 22 Campath Campath NNP cord-006856-b1w25ob5 951 23 ) ) -RRB- cord-006856-b1w25ob5 951 24 at at IN cord-006856-b1w25ob5 951 25 a a DT cord-006856-b1w25ob5 951 26 total total JJ cord-006856-b1w25ob5 951 27 dose dose NN cord-006856-b1w25ob5 951 28 of of IN cord-006856-b1w25ob5 951 29 50 50 CD cord-006856-b1w25ob5 951 30 mg mg NNS cord-006856-b1w25ob5 951 31 over over IN cord-006856-b1w25ob5 951 32 5 5 CD cord-006856-b1w25ob5 951 33 days day NNS cord-006856-b1w25ob5 951 34 and and CC cord-006856-b1w25ob5 951 35 graft graft NN cord-006856-b1w25ob5 951 36 - - HYPH cord-006856-b1w25ob5 951 37 versus versus IN cord-006856-b1w25ob5 951 38 - - HYPH cord-006856-b1w25ob5 951 39 host host NN cord-006856-b1w25ob5 951 40 disease disease NN cord-006856-b1w25ob5 951 41 ( ( -LRB- cord-006856-b1w25ob5 951 42 GvHD GvHD NNP cord-006856-b1w25ob5 951 43 ) ) -RRB- cord-006856-b1w25ob5 951 44 prophylaxis prophylaxis NN cord-006856-b1w25ob5 951 45 of of IN cord-006856-b1w25ob5 951 46 Cyclosporine Cyclosporine NNP cord-006856-b1w25ob5 951 47 A. a. NN cord-006856-b1w25ob5 951 48 PBSC PBSC NNP cord-006856-b1w25ob5 951 49 of of IN cord-006856-b1w25ob5 951 50 donors donor NNS cord-006856-b1w25ob5 951 51 were be VBD cord-006856-b1w25ob5 951 52 collected collect VBN cord-006856-b1w25ob5 951 53 after after IN cord-006856-b1w25ob5 951 54 G G NNP cord-006856-b1w25ob5 951 55 - - HYPH cord-006856-b1w25ob5 951 56 CSF csf NN cord-006856-b1w25ob5 951 57 stimulation stimulation NN cord-006856-b1w25ob5 951 58 at at IN cord-006856-b1w25ob5 951 59 10 10 CD cord-006856-b1w25ob5 951 60 µg µg NN cord-006856-b1w25ob5 951 61 / / SYM cord-006856-b1w25ob5 951 62 kg kg NNS cord-006856-b1w25ob5 951 63 of of IN cord-006856-b1w25ob5 951 64 body body NN cord-006856-b1w25ob5 951 65 weight weight NN cord-006856-b1w25ob5 951 66 given give VBN cord-006856-b1w25ob5 951 67 for for IN cord-006856-b1w25ob5 951 68 4 4 CD cord-006856-b1w25ob5 951 69 days day NNS cord-006856-b1w25ob5 951 70 . . . cord-006856-b1w25ob5 952 1 Results result NNS cord-006856-b1w25ob5 952 2 . . . cord-006856-b1w25ob5 953 1 Patient Patient NNP cord-006856-b1w25ob5 953 2 2 2 CD cord-006856-b1w25ob5 953 3 rejected reject VBD cord-006856-b1w25ob5 953 4 his -PRON- PRP$ cord-006856-b1w25ob5 953 5 unrelated unrelated JJ cord-006856-b1w25ob5 953 6 - - HYPH cord-006856-b1w25ob5 953 7 donor donor NN cord-006856-b1w25ob5 953 8 graft graft NN cord-006856-b1w25ob5 953 9 and and CC cord-006856-b1w25ob5 953 10 received receive VBD cord-006856-b1w25ob5 953 11 an an DT cord-006856-b1w25ob5 953 12 autologous autologous JJ cord-006856-b1w25ob5 953 13 stem stem NN cord-006856-b1w25ob5 953 14 cell cell NN cord-006856-b1w25ob5 953 15 infusion infusion NN cord-006856-b1w25ob5 953 16 44 44 CD cord-006856-b1w25ob5 953 17 days day NNS cord-006856-b1w25ob5 953 18 thereafter thereafter RB cord-006856-b1w25ob5 953 19 resulting result VBG cord-006856-b1w25ob5 953 20 in in IN cord-006856-b1w25ob5 953 21 sustained sustained JJ cord-006856-b1w25ob5 953 22 hematologic hematologic JJ cord-006856-b1w25ob5 953 23 recovery recovery NN cord-006856-b1w25ob5 953 24 ( ( -LRB- cord-006856-b1w25ob5 953 25 ANC ANC NNP cord-006856-b1w25ob5 953 26 , , , cord-006856-b1w25ob5 953 27 > > XX cord-006856-b1w25ob5 954 1 0.5 0.5 CD cord-006856-b1w25ob5 954 2 G g NN cord-006856-b1w25ob5 954 3 / / SYM cord-006856-b1w25ob5 954 4 l l NN cord-006856-b1w25ob5 954 5 on on IN cord-006856-b1w25ob5 954 6 day day NN cord-006856-b1w25ob5 954 7 10 10 CD cord-006856-b1w25ob5 954 8 ) ) -RRB- cord-006856-b1w25ob5 954 9 . . . cord-006856-b1w25ob5 955 1 All all DT cord-006856-b1w25ob5 955 2 other other JJ cord-006856-b1w25ob5 955 3 patients patient NNS cord-006856-b1w25ob5 955 4 engrafted engraft VBN cord-006856-b1w25ob5 955 5 uneventfully uneventfully RB cord-006856-b1w25ob5 955 6 ( ( -LRB- cord-006856-b1w25ob5 955 7 ANC ANC NNP cord-006856-b1w25ob5 955 8 , , , cord-006856-b1w25ob5 955 9 > > XX cord-006856-b1w25ob5 956 1 0.5 0.5 CD cord-006856-b1w25ob5 956 2 G g NN cord-006856-b1w25ob5 956 3 / / SYM cord-006856-b1w25ob5 956 4 l l NN cord-006856-b1w25ob5 956 5 on on IN cord-006856-b1w25ob5 956 6 days day NNS cord-006856-b1w25ob5 956 7 14 14 CD cord-006856-b1w25ob5 956 8 - - SYM cord-006856-b1w25ob5 956 9 16 16 CD cord-006856-b1w25ob5 956 10 ; ; , cord-006856-b1w25ob5 956 11 platelets platelet NNS cord-006856-b1w25ob5 956 12 , , , cord-006856-b1w25ob5 956 13 > > XX cord-006856-b1w25ob5 956 14 20 20 CD cord-006856-b1w25ob5 956 15 G g NN cord-006856-b1w25ob5 956 16 / / SYM cord-006856-b1w25ob5 956 17 l l NN cord-006856-b1w25ob5 956 18 on on IN cord-006856-b1w25ob5 956 19 days day NNS cord-006856-b1w25ob5 956 20 10 10 CD cord-006856-b1w25ob5 956 21 - - SYM cord-006856-b1w25ob5 956 22 13 13 CD cord-006856-b1w25ob5 956 23 ) ) -RRB- cord-006856-b1w25ob5 956 24 . . . cord-006856-b1w25ob5 957 1 None none NN cord-006856-b1w25ob5 957 2 of of IN cord-006856-b1w25ob5 957 3 the the DT cord-006856-b1w25ob5 957 4 patients patient NNS cord-006856-b1w25ob5 957 5 showed show VBD cord-006856-b1w25ob5 957 6 evidence evidence NN cord-006856-b1w25ob5 957 7 of of IN cord-006856-b1w25ob5 957 8 acute acute JJ cord-006856-b1w25ob5 957 9 or or CC cord-006856-b1w25ob5 957 10 chronic chronic JJ cord-006856-b1w25ob5 957 11 GvHD gvhd NN cord-006856-b1w25ob5 957 12 . . . cord-006856-b1w25ob5 958 1 Two two CD cord-006856-b1w25ob5 958 2 patients patient NNS cord-006856-b1w25ob5 958 3 achieved achieve VBD cord-006856-b1w25ob5 958 4 complete complete JJ cord-006856-b1w25ob5 958 5 donor donor NN cord-006856-b1w25ob5 958 6 chimerism chimerism NN cord-006856-b1w25ob5 958 7 in in IN cord-006856-b1w25ob5 958 8 myeloid myeloid JJ cord-006856-b1w25ob5 958 9 and and CC cord-006856-b1w25ob5 958 10 lymphoid lymphoid JJ cord-006856-b1w25ob5 958 11 cell cell NN cord-006856-b1w25ob5 958 12 populations population NNS cord-006856-b1w25ob5 958 13 , , , cord-006856-b1w25ob5 958 14 another another DT cord-006856-b1w25ob5 958 15 one one NN cord-006856-b1w25ob5 958 16 had have VBD cord-006856-b1w25ob5 958 17 prolonged prolong VBN cord-006856-b1w25ob5 958 18 mixed mixed JJ cord-006856-b1w25ob5 958 19 chimerism chimerism NN cord-006856-b1w25ob5 958 20 and and CC cord-006856-b1w25ob5 958 21 was be VBD cord-006856-b1w25ob5 958 22 given give VBN cord-006856-b1w25ob5 958 23 a a DT cord-006856-b1w25ob5 958 24 donor donor NN cord-006856-b1w25ob5 958 25 leukocyte leukocyte NN cord-006856-b1w25ob5 958 26 infusion infusion NN cord-006856-b1w25ob5 958 27 of of IN cord-006856-b1w25ob5 958 28 1 1 CD cord-006856-b1w25ob5 958 29 × × NNP cord-006856-b1w25ob5 958 30 10 10 CD cord-006856-b1w25ob5 958 31 6 6 CD cord-006856-b1w25ob5 958 32 CD3-positive cd3-positive NN cord-006856-b1w25ob5 958 33 cells cell NNS cord-006856-b1w25ob5 958 34 per per IN cord-006856-b1w25ob5 958 35 kg kg NN cord-006856-b1w25ob5 958 36 . . . cord-006856-b1w25ob5 959 1 One one CD cord-006856-b1w25ob5 959 2 patient patient NN cord-006856-b1w25ob5 959 3 experienced experience VBD cord-006856-b1w25ob5 959 4 a a DT cord-006856-b1w25ob5 959 5 CMV CMV NNP cord-006856-b1w25ob5 959 6 reactivation reactivation NN cord-006856-b1w25ob5 959 7 on on IN cord-006856-b1w25ob5 959 8 day day NN cord-006856-b1w25ob5 959 9 51 51 CD cord-006856-b1w25ob5 959 10 after after IN cord-006856-b1w25ob5 959 11 SCT SCT NNP cord-006856-b1w25ob5 959 12 and and CC cord-006856-b1w25ob5 959 13 a a DT cord-006856-b1w25ob5 959 14 sarcoidosis sarcoidosis NN cord-006856-b1w25ob5 959 15 on on IN cord-006856-b1w25ob5 959 16 day day NN cord-006856-b1w25ob5 959 17 +150 +150 NNP cord-006856-b1w25ob5 959 18 . . . cord-006856-b1w25ob5 960 1 Three three CD cord-006856-b1w25ob5 960 2 months month NNS cord-006856-b1w25ob5 960 3 after after IN cord-006856-b1w25ob5 960 4 SCT SCT NNP cord-006856-b1w25ob5 960 5 , , , cord-006856-b1w25ob5 960 6 all all DT cord-006856-b1w25ob5 960 7 patients patient NNS cord-006856-b1w25ob5 960 8 showed show VBD cord-006856-b1w25ob5 960 9 marked marked JJ cord-006856-b1w25ob5 960 10 regression regression NN cord-006856-b1w25ob5 960 11 of of IN cord-006856-b1w25ob5 960 12 disease disease NN cord-006856-b1w25ob5 960 13 . . . cord-006856-b1w25ob5 961 1 After after IN cord-006856-b1w25ob5 961 2 a a DT cord-006856-b1w25ob5 961 3 follow follow NN cord-006856-b1w25ob5 961 4 - - HYPH cord-006856-b1w25ob5 961 5 up up NN cord-006856-b1w25ob5 961 6 of of IN cord-006856-b1w25ob5 961 7 5 5 CD cord-006856-b1w25ob5 961 8 to to TO cord-006856-b1w25ob5 961 9 11 11 CD cord-006856-b1w25ob5 961 10 months month NNS cord-006856-b1w25ob5 961 11 ( ( -LRB- cord-006856-b1w25ob5 961 12 median median NN cord-006856-b1w25ob5 961 13 , , , cord-006856-b1w25ob5 961 14 8 8 CD cord-006856-b1w25ob5 961 15 months month NNS cord-006856-b1w25ob5 961 16 ) ) -RRB- cord-006856-b1w25ob5 961 17 , , , cord-006856-b1w25ob5 961 18 2 2 CD cord-006856-b1w25ob5 961 19 patients patient NNS cord-006856-b1w25ob5 961 20 experienced experience VBD cord-006856-b1w25ob5 961 21 progression progression NN cord-006856-b1w25ob5 961 22 undergoing undergo VBG cord-006856-b1w25ob5 961 23 salvage salvage NN cord-006856-b1w25ob5 961 24 chemotherapy chemotherapy NN cord-006856-b1w25ob5 961 25 . . . cord-006856-b1w25ob5 962 1 Time time NN cord-006856-b1w25ob5 962 2 to to IN cord-006856-b1w25ob5 962 3 progres progres NN cord-006856-b1w25ob5 962 4 - - HYPH cord-006856-b1w25ob5 962 5 sion sion NNP cord-006856-b1w25ob5 962 6 was be VBD cord-006856-b1w25ob5 962 7 5 5 CD cord-006856-b1w25ob5 962 8 and and CC cord-006856-b1w25ob5 962 9 6 6 CD cord-006856-b1w25ob5 962 10 months month NNS cord-006856-b1w25ob5 962 11 , , , cord-006856-b1w25ob5 962 12 respectively respectively RB cord-006856-b1w25ob5 962 13 . . . cord-006856-b1w25ob5 963 1 Two two CD cord-006856-b1w25ob5 963 2 patients patient NNS cord-006856-b1w25ob5 963 3 remained remain VBD cord-006856-b1w25ob5 963 4 progression progression NN cord-006856-b1w25ob5 963 5 free free JJ cord-006856-b1w25ob5 963 6 for for IN cord-006856-b1w25ob5 963 7 7 7 CD cord-006856-b1w25ob5 963 8 and and CC cord-006856-b1w25ob5 963 9 11 11 CD cord-006856-b1w25ob5 963 10 months month NNS cord-006856-b1w25ob5 963 11 , , , cord-006856-b1w25ob5 963 12 respectively respectively RB cord-006856-b1w25ob5 963 13 . . . cord-006856-b1w25ob5 964 1 Overall overall JJ cord-006856-b1w25ob5 964 2 survival survival NN cord-006856-b1w25ob5 964 3 is be VBZ cord-006856-b1w25ob5 964 4 5 5 CD cord-006856-b1w25ob5 964 5 to to TO cord-006856-b1w25ob5 964 6 11 11 CD cord-006856-b1w25ob5 964 7 months month NNS cord-006856-b1w25ob5 964 8 . . . cord-006856-b1w25ob5 965 1 Conclusions conclusion NNS cord-006856-b1w25ob5 965 2 . . . cord-006856-b1w25ob5 966 1 Our -PRON- PRP$ cord-006856-b1w25ob5 966 2 data datum NNS cord-006856-b1w25ob5 966 3 demonstrate demonstrate VBP cord-006856-b1w25ob5 966 4 that that IN cord-006856-b1w25ob5 966 5 this this DT cord-006856-b1w25ob5 966 6 regimen regimen NN cord-006856-b1w25ob5 966 7 was be VBD cord-006856-b1w25ob5 966 8 well well RB cord-006856-b1w25ob5 966 9 tolerated tolerate VBN cord-006856-b1w25ob5 966 10 with with IN cord-006856-b1w25ob5 966 11 a a DT cord-006856-b1w25ob5 966 12 low low JJ cord-006856-b1w25ob5 966 13 risk risk NN cord-006856-b1w25ob5 966 14 of of IN cord-006856-b1w25ob5 966 15 GvHD gvhd NN cord-006856-b1w25ob5 966 16 and and CC cord-006856-b1w25ob5 966 17 transplant transplant NN cord-006856-b1w25ob5 966 18 - - HYPH cord-006856-b1w25ob5 966 19 associated associate VBN cord-006856-b1w25ob5 966 20 morbidity morbidity NN cord-006856-b1w25ob5 966 21 . . . cord-006856-b1w25ob5 967 1 An an DT cord-006856-b1w25ob5 967 2 increased increased JJ cord-006856-b1w25ob5 967 3 dosage dosage NN cord-006856-b1w25ob5 967 4 of of IN cord-006856-b1w25ob5 967 5 campath campath NNP cord-006856-b1w25ob5 967 6 could could MD cord-006856-b1w25ob5 967 7 be be VB cord-006856-b1w25ob5 967 8 considered consider VBN cord-006856-b1w25ob5 967 9 to to TO cord-006856-b1w25ob5 967 10 prevent prevent VB cord-006856-b1w25ob5 967 11 rejection rejection NN cord-006856-b1w25ob5 967 12 in in IN cord-006856-b1w25ob5 967 13 unrelated unrelated JJ cord-006856-b1w25ob5 967 14 - - HYPH cord-006856-b1w25ob5 967 15 donor donor NN cord-006856-b1w25ob5 967 16 transplantation transplantation NN cord-006856-b1w25ob5 967 17 . . . cord-006856-b1w25ob5 968 1 Longer long RBR cord-006856-b1w25ob5 968 2 follow follow NN cord-006856-b1w25ob5 968 3 - - HYPH cord-006856-b1w25ob5 968 4 up up NN cord-006856-b1w25ob5 968 5 and and CC cord-006856-b1w25ob5 968 6 larger large JJR cord-006856-b1w25ob5 968 7 patient patient JJ cord-006856-b1w25ob5 968 8 numbers number NNS cord-006856-b1w25ob5 968 9 are be VBP cord-006856-b1w25ob5 968 10 warranted warrant VBN cord-006856-b1w25ob5 968 11 for for IN cord-006856-b1w25ob5 968 12 assessment assessment NN cord-006856-b1w25ob5 968 13 of of IN cord-006856-b1w25ob5 968 14 the the DT cord-006856-b1w25ob5 968 15 efficacy efficacy NN cord-006856-b1w25ob5 968 16 of of IN cord-006856-b1w25ob5 968 17 Campath Campath NNP cord-006856-b1w25ob5 968 18 - - HYPH cord-006856-b1w25ob5 968 19 BEAM BEAM NNP cord-006856-b1w25ob5 968 20 with with IN cord-006856-b1w25ob5 968 21 regards regard NNS cord-006856-b1w25ob5 968 22 to to IN cord-006856-b1w25ob5 968 23 durable durable JJ cord-006856-b1w25ob5 968 24 remissions remission NNS cord-006856-b1w25ob5 968 25 . . . cord-006856-b1w25ob5 968 26 _SP cord-006856-b1w25ob5 969 1 Background background NN cord-006856-b1w25ob5 969 2 . . . cord-006856-b1w25ob5 970 1 As as IN cord-006856-b1w25ob5 970 2 long long JJ cord-006856-b1w25ob5 970 3 - - HYPH cord-006856-b1w25ob5 970 4 term term NN cord-006856-b1w25ob5 970 5 survivors survivor NNS cord-006856-b1w25ob5 970 6 of of IN cord-006856-b1w25ob5 970 7 hematopoietic hematopoietic JJ cord-006856-b1w25ob5 970 8 cell cell NN cord-006856-b1w25ob5 970 9 transplantation transplantation NN cord-006856-b1w25ob5 970 10 ( ( -LRB- cord-006856-b1w25ob5 970 11 HCT HCT NNP cord-006856-b1w25ob5 970 12 ) ) -RRB- cord-006856-b1w25ob5 970 13 become become VBP cord-006856-b1w25ob5 970 14 more more RBR cord-006856-b1w25ob5 970 15 numerous numerous JJ cord-006856-b1w25ob5 970 16 , , , cord-006856-b1w25ob5 970 17 studies study NNS cord-006856-b1w25ob5 970 18 addressing address VBG cord-006856-b1w25ob5 970 19 the the DT cord-006856-b1w25ob5 970 20 issue issue NN cord-006856-b1w25ob5 970 21 of of IN cord-006856-b1w25ob5 970 22 long long JJ cord-006856-b1w25ob5 970 23 - - HYPH cord-006856-b1w25ob5 970 24 term term NN cord-006856-b1w25ob5 970 25 follow follow NN cord-006856-b1w25ob5 970 26 - - HYPH cord-006856-b1w25ob5 970 27 up up NN cord-006856-b1w25ob5 970 28 are be VBP cord-006856-b1w25ob5 970 29 necessary necessary JJ cord-006856-b1w25ob5 970 30 . . . cord-006856-b1w25ob5 971 1 In in IN cord-006856-b1w25ob5 971 2 this this DT cord-006856-b1w25ob5 971 3 study study NN cord-006856-b1w25ob5 971 4 , , , cord-006856-b1w25ob5 971 5 we -PRON- PRP cord-006856-b1w25ob5 971 6 report report VBP cord-006856-b1w25ob5 971 7 on on IN cord-006856-b1w25ob5 971 8 the the DT cord-006856-b1w25ob5 971 9 quality quality NN cord-006856-b1w25ob5 971 10 of of IN cord-006856-b1w25ob5 971 11 life life NN cord-006856-b1w25ob5 971 12 ( ( -LRB- cord-006856-b1w25ob5 971 13 QOL QOL NNP cord-006856-b1w25ob5 971 14 ) ) -RRB- cord-006856-b1w25ob5 971 15 of of IN cord-006856-b1w25ob5 971 16 HCT hct NN cord-006856-b1w25ob5 971 17 patients patient NNS cord-006856-b1w25ob5 971 18 who who WP cord-006856-b1w25ob5 971 19 were be VBD cord-006856-b1w25ob5 971 20 alive alive JJ cord-006856-b1w25ob5 971 21 at at IN cord-006856-b1w25ob5 971 22 least least JJS cord-006856-b1w25ob5 971 23 at at IN cord-006856-b1w25ob5 971 24 5 5 CD cord-006856-b1w25ob5 971 25 years year NNS cord-006856-b1w25ob5 971 26 after after IN cord-006856-b1w25ob5 971 27 transplantation transplantation NN cord-006856-b1w25ob5 971 28 in in IN cord-006856-b1w25ob5 971 29 comparison comparison NN cord-006856-b1w25ob5 971 30 with with IN cord-006856-b1w25ob5 971 31 an an DT cord-006856-b1w25ob5 971 32 age age NN cord-006856-b1w25ob5 971 33 - - HYPH cord-006856-b1w25ob5 971 34 and and CC cord-006856-b1w25ob5 971 35 sex sex NN cord-006856-b1w25ob5 971 36 - - HYPH cord-006856-b1w25ob5 971 37 matched match VBN cord-006856-b1w25ob5 971 38 sample sample NN cord-006856-b1w25ob5 971 39 of of IN cord-006856-b1w25ob5 971 40 healthy healthy JJ cord-006856-b1w25ob5 971 41 controls control NNS cord-006856-b1w25ob5 971 42 assessed assess VBN cord-006856-b1w25ob5 971 43 in in IN cord-006856-b1w25ob5 971 44 the the DT cord-006856-b1w25ob5 971 45 same same JJ cord-006856-b1w25ob5 971 46 time time NN cord-006856-b1w25ob5 971 47 period period NN cord-006856-b1w25ob5 971 48 and and CC cord-006856-b1w25ob5 971 49 the the DT cord-006856-b1w25ob5 971 50 same same JJ cord-006856-b1w25ob5 971 51 geographical geographical JJ cord-006856-b1w25ob5 971 52 region region NN cord-006856-b1w25ob5 971 53 . . . cord-006856-b1w25ob5 972 1 Methods method NNS cord-006856-b1w25ob5 972 2 . . . cord-006856-b1w25ob5 973 1 The the DT cord-006856-b1w25ob5 973 2 EORTC EORTC NNP cord-006856-b1w25ob5 973 3 - - HYPH cord-006856-b1w25ob5 973 4 Quality Quality NNP cord-006856-b1w25ob5 973 5 of of IN cord-006856-b1w25ob5 973 6 Life Life NNP cord-006856-b1w25ob5 973 7 Questionnaire Questionnaire NNP cord-006856-b1w25ob5 973 8 ( ( -LRB- cord-006856-b1w25ob5 973 9 EORTC EORTC NNP cord-006856-b1w25ob5 973 10 - - HYPH cord-006856-b1w25ob5 973 11 QLQ QLQ NNP cord-006856-b1w25ob5 973 12 C30 C30 NNP cord-006856-b1w25ob5 973 13 ) ) -RRB- cord-006856-b1w25ob5 973 14 was be VBD cord-006856-b1w25ob5 973 15 sent send VBN cord-006856-b1w25ob5 973 16 by by IN cord-006856-b1w25ob5 973 17 post post NN cord-006856-b1w25ob5 973 18 to to IN cord-006856-b1w25ob5 973 19 39 39 CD cord-006856-b1w25ob5 973 20 HCT HCT NNP cord-006856-b1w25ob5 973 21 survivors survivor NNS cord-006856-b1w25ob5 973 22 . . . cord-006856-b1w25ob5 974 1 Thirty thirty CD cord-006856-b1w25ob5 974 2 - - HYPH cord-006856-b1w25ob5 974 3 four four CD cord-006856-b1w25ob5 974 4 patients patient NNS cord-006856-b1w25ob5 974 5 answered answer VBD cord-006856-b1w25ob5 974 6 the the DT cord-006856-b1w25ob5 974 7 questionnaire questionnaire NN cord-006856-b1w25ob5 974 8 . . . cord-006856-b1w25ob5 975 1 Patients patient NNS cord-006856-b1w25ob5 975 2 were be VBD cord-006856-b1w25ob5 975 3 compared compare VBN cord-006856-b1w25ob5 975 4 with with IN cord-006856-b1w25ob5 975 5 68 68 CD cord-006856-b1w25ob5 975 6 healthy healthy JJ cord-006856-b1w25ob5 975 7 controls control NNS cord-006856-b1w25ob5 975 8 from from IN cord-006856-b1w25ob5 975 9 the the DT cord-006856-b1w25ob5 975 10 same same JJ cord-006856-b1w25ob5 975 11 geographical geographical JJ cord-006856-b1w25ob5 975 12 region region NN cord-006856-b1w25ob5 975 13 . . . cord-006856-b1w25ob5 976 1 Patients patient NNS cord-006856-b1w25ob5 976 2 and and CC cord-006856-b1w25ob5 976 3 controls control NNS cord-006856-b1w25ob5 976 4 completed complete VBD cord-006856-b1w25ob5 976 5 the the DT cord-006856-b1w25ob5 976 6 EORTC EORTC NNP cord-006856-b1w25ob5 976 7 in in IN cord-006856-b1w25ob5 976 8 the the DT cord-006856-b1w25ob5 976 9 same same JJ cord-006856-b1w25ob5 976 10 time time NN cord-006856-b1w25ob5 976 11 period period NN cord-006856-b1w25ob5 976 12 . . . cord-006856-b1w25ob5 977 1 Results result NNS cord-006856-b1w25ob5 977 2 . . . cord-006856-b1w25ob5 978 1 Mann Mann NNP cord-006856-b1w25ob5 978 2 - - HYPH cord-006856-b1w25ob5 978 3 Whitney Whitney NNP cord-006856-b1w25ob5 978 4 U U NNP cord-006856-b1w25ob5 978 5 tests test NNS cord-006856-b1w25ob5 978 6 identified identify VBD cord-006856-b1w25ob5 978 7 significantly significantly RB cord-006856-b1w25ob5 978 8 lower low JJR cord-006856-b1w25ob5 978 9 QOL QOL NNP cord-006856-b1w25ob5 978 10 on on IN cord-006856-b1w25ob5 978 11 the the DT cord-006856-b1w25ob5 978 12 dimensions dimension NNS cord-006856-b1w25ob5 978 13 of of IN cord-006856-b1w25ob5 978 14 physical physical JJ cord-006856-b1w25ob5 978 15 and and CC cord-006856-b1w25ob5 978 16 social social JJ cord-006856-b1w25ob5 978 17 functioning functioning NN cord-006856-b1w25ob5 978 18 and and CC cord-006856-b1w25ob5 978 19 on on IN cord-006856-b1w25ob5 978 20 the the DT cord-006856-b1w25ob5 978 21 financial financial JJ cord-006856-b1w25ob5 978 22 impact impact NN cord-006856-b1w25ob5 978 23 symptom symptom NN cord-006856-b1w25ob5 978 24 scale scale NN cord-006856-b1w25ob5 978 25 . . . cord-006856-b1w25ob5 979 1 Conclusions conclusion NNS cord-006856-b1w25ob5 979 2 . . . cord-006856-b1w25ob5 980 1 Patients patient NNS cord-006856-b1w25ob5 980 2 who who WP cord-006856-b1w25ob5 980 3 had have VBD cord-006856-b1w25ob5 980 4 survived survive VBN cord-006856-b1w25ob5 980 5 their -PRON- PRP$ cord-006856-b1w25ob5 980 6 HCT hct NN cord-006856-b1w25ob5 980 7 for for IN cord-006856-b1w25ob5 980 8 more more JJR cord-006856-b1w25ob5 980 9 than than IN cord-006856-b1w25ob5 980 10 5 5 CD cord-006856-b1w25ob5 980 11 years year NNS cord-006856-b1w25ob5 980 12 did do VBD cord-006856-b1w25ob5 980 13 generally generally RB cord-006856-b1w25ob5 980 14 well well RB cord-006856-b1w25ob5 980 15 in in IN cord-006856-b1w25ob5 980 16 terms term NNS cord-006856-b1w25ob5 980 17 of of IN cord-006856-b1w25ob5 980 18 global global JJ cord-006856-b1w25ob5 980 19 QOL QOL NNP cord-006856-b1w25ob5 980 20 . . . cord-006856-b1w25ob5 981 1 This this DT cord-006856-b1w25ob5 981 2 is be VBZ cord-006856-b1w25ob5 981 3 consistent consistent JJ cord-006856-b1w25ob5 981 4 with with IN cord-006856-b1w25ob5 981 5 Kiss Kiss NNP cord-006856-b1w25ob5 981 6 et et NNP cord-006856-b1w25ob5 981 7 al al NNP cord-006856-b1w25ob5 981 8 . . . cord-006856-b1w25ob5 982 1 ( ( -LRB- cord-006856-b1w25ob5 982 2 2002 2002 CD cord-006856-b1w25ob5 982 3 ) ) -RRB- cord-006856-b1w25ob5 982 4 who who WP cord-006856-b1w25ob5 982 5 found find VBD cord-006856-b1w25ob5 982 6 that that IN cord-006856-b1w25ob5 982 7 CML CML NNP cord-006856-b1w25ob5 982 8 patients patient NNS cord-006856-b1w25ob5 982 9 who who WP cord-006856-b1w25ob5 982 10 were be VBD cord-006856-b1w25ob5 982 11 alive alive JJ cord-006856-b1w25ob5 982 12 at at IN cord-006856-b1w25ob5 982 13 least least RBS cord-006856-b1w25ob5 982 14 10 10 CD cord-006856-b1w25ob5 982 15 years year NNS cord-006856-b1w25ob5 982 16 after after IN cord-006856-b1w25ob5 982 17 HCT HCT NNP cord-006856-b1w25ob5 982 18 report report VBP cord-006856-b1w25ob5 982 19 lower low JJR cord-006856-b1w25ob5 982 20 physical physical JJ cord-006856-b1w25ob5 982 21 functioning functioning NN cord-006856-b1w25ob5 982 22 in in IN cord-006856-b1w25ob5 982 23 comparison comparison NN cord-006856-b1w25ob5 982 24 with with IN cord-006856-b1w25ob5 982 25 healthy healthy JJ cord-006856-b1w25ob5 982 26 controls control NNS cord-006856-b1w25ob5 982 27 . . . cord-006856-b1w25ob5 983 1 Problems problem NNS cord-006856-b1w25ob5 983 2 in in IN cord-006856-b1w25ob5 983 3 the the DT cord-006856-b1w25ob5 983 4 areas area NNS cord-006856-b1w25ob5 983 5 of of IN cord-006856-b1w25ob5 983 6 social social JJ cord-006856-b1w25ob5 983 7 functioning functioning NN cord-006856-b1w25ob5 983 8 and and CC cord-006856-b1w25ob5 983 9 financial financial JJ cord-006856-b1w25ob5 983 10 difficulty difficulty NN cord-006856-b1w25ob5 983 11 can can MD cord-006856-b1w25ob5 983 12 possibly possibly RB cord-006856-b1w25ob5 983 13 be be VB cord-006856-b1w25ob5 983 14 addressed address VBN cord-006856-b1w25ob5 983 15 by by IN cord-006856-b1w25ob5 983 16 intensive intensive JJ cord-006856-b1w25ob5 983 17 rehabilitation rehabilitation NN cord-006856-b1w25ob5 983 18 processes process NNS cord-006856-b1w25ob5 983 19 integrating integrate VBG cord-006856-b1w25ob5 983 20 patients patient NNS cord-006856-b1w25ob5 983 21 , , , cord-006856-b1w25ob5 983 22 family family NN cord-006856-b1w25ob5 983 23 members member NNS cord-006856-b1w25ob5 983 24 , , , cord-006856-b1w25ob5 983 25 and and CC cord-006856-b1w25ob5 983 26 significant significant JJ cord-006856-b1w25ob5 983 27 others other NNS cord-006856-b1w25ob5 983 28 . . . cord-006856-b1w25ob5 984 1 Interdisciplinary interdisciplinary JJ cord-006856-b1w25ob5 984 2 ( ( -LRB- cord-006856-b1w25ob5 984 3 medical medical JJ cord-006856-b1w25ob5 984 4 , , , cord-006856-b1w25ob5 984 5 psychological psychological JJ cord-006856-b1w25ob5 984 6 , , , cord-006856-b1w25ob5 984 7 and and CC cord-006856-b1w25ob5 984 8 social social JJ cord-006856-b1w25ob5 984 9 ) ) -RRB- cord-006856-b1w25ob5 984 10 treatment treatment NN cord-006856-b1w25ob5 984 11 of of IN cord-006856-b1w25ob5 984 12 patients patient NNS cord-006856-b1w25ob5 984 13 should should MD cord-006856-b1w25ob5 984 14 not not RB cord-006856-b1w25ob5 984 15 come come VB cord-006856-b1w25ob5 984 16 to to IN cord-006856-b1w25ob5 984 17 an an DT cord-006856-b1w25ob5 984 18 end end NN cord-006856-b1w25ob5 984 19 after after IN cord-006856-b1w25ob5 984 20 the the DT cord-006856-b1w25ob5 984 21 acute acute JJ cord-006856-b1w25ob5 984 22 phase phase NN cord-006856-b1w25ob5 984 23 of of IN cord-006856-b1w25ob5 984 24 the the DT cord-006856-b1w25ob5 984 25 illness illness NN cord-006856-b1w25ob5 984 26 but but CC cord-006856-b1w25ob5 984 27 should should MD cord-006856-b1w25ob5 984 28 continue continue VB cord-006856-b1w25ob5 984 29 during during IN cord-006856-b1w25ob5 984 30 checkups checkup NNS cord-006856-b1w25ob5 984 31 following follow VBG cord-006856-b1w25ob5 984 32 transplantation transplantation NN cord-006856-b1w25ob5 984 33 . . . cord-006856-b1w25ob5 985 1 Background background NN cord-006856-b1w25ob5 985 2 . . . cord-006856-b1w25ob5 986 1 Bone bone NN cord-006856-b1w25ob5 986 2 marrow marrow NN cord-006856-b1w25ob5 986 3 transplantation transplantation NN cord-006856-b1w25ob5 986 4 ( ( -LRB- cord-006856-b1w25ob5 986 5 BMT BMT NNP cord-006856-b1w25ob5 986 6 ) ) -RRB- cord-006856-b1w25ob5 986 7 together together RB cord-006856-b1w25ob5 986 8 with with IN cord-006856-b1w25ob5 986 9 costimulation costimulation NN cord-006856-b1w25ob5 986 10 blockade blockade NN cord-006856-b1w25ob5 986 11 can can MD cord-006856-b1w25ob5 986 12 reliably reliably RB cord-006856-b1w25ob5 986 13 induce induce VB cord-006856-b1w25ob5 986 14 mixed mixed JJ cord-006856-b1w25ob5 986 15 chimerism chimerism NN cord-006856-b1w25ob5 986 16 and and CC cord-006856-b1w25ob5 986 17 tolerance tolerance NN cord-006856-b1w25ob5 986 18 in in IN cord-006856-b1w25ob5 986 19 certain certain JJ cord-006856-b1w25ob5 986 20 experimental experimental JJ cord-006856-b1w25ob5 986 21 models model NNS cord-006856-b1w25ob5 986 22 . . . cord-006856-b1w25ob5 987 1 Natural natural JJ cord-006856-b1w25ob5 987 2 killer killer NN cord-006856-b1w25ob5 987 3 T t NN cord-006856-b1w25ob5 987 4 cells cell NNS cord-006856-b1w25ob5 987 5 play play VBP cord-006856-b1w25ob5 987 6 an an DT cord-006856-b1w25ob5 987 7 important important JJ cord-006856-b1w25ob5 987 8 role role NN cord-006856-b1w25ob5 987 9 in in IN cord-006856-b1w25ob5 987 10 the the DT cord-006856-b1w25ob5 987 11 induction induction NN cord-006856-b1w25ob5 987 12 of of IN cord-006856-b1w25ob5 987 13 tolerance tolerance NN cord-006856-b1w25ob5 987 14 in in IN cord-006856-b1w25ob5 987 15 several several JJ cord-006856-b1w25ob5 987 16 transplantation transplantation NN cord-006856-b1w25ob5 987 17 and and CC cord-006856-b1w25ob5 987 18 autoimmunity autoimmunity NN cord-006856-b1w25ob5 987 19 models model NNS cord-006856-b1w25ob5 987 20 . . . cord-006856-b1w25ob5 988 1 It -PRON- PRP cord-006856-b1w25ob5 988 2 has have VBZ cord-006856-b1w25ob5 988 3 been be VBN cord-006856-b1w25ob5 988 4 reported report VBN cord-006856-b1w25ob5 988 5 , , , cord-006856-b1w25ob5 988 6 for for IN cord-006856-b1w25ob5 988 7 instance instance NN cord-006856-b1w25ob5 988 8 , , , cord-006856-b1w25ob5 988 9 that that DT cord-006856-b1w25ob5 988 10 activation activation NN cord-006856-b1w25ob5 988 11 of of IN cord-006856-b1w25ob5 988 12 NK NK NNP cord-006856-b1w25ob5 988 13 T T NNP cord-006856-b1w25ob5 988 14 cells cell NNS cord-006856-b1w25ob5 988 15 by by IN cord-006856-b1w25ob5 988 16 α α NN cord-006856-b1w25ob5 988 17 - - HYPH cord-006856-b1w25ob5 988 18 galactosylceramide galactosylceramide NN cord-006856-b1w25ob5 988 19 ( ( -LRB- cord-006856-b1w25ob5 988 20 α α NN cord-006856-b1w25ob5 988 21 - - HYPH cord-006856-b1w25ob5 988 22 Gal Gal NNP cord-006856-b1w25ob5 988 23 ) ) -RRB- cord-006856-b1w25ob5 988 24 can can MD cord-006856-b1w25ob5 988 25 prevent prevent VB cord-006856-b1w25ob5 988 26 the the DT cord-006856-b1w25ob5 988 27 onset onset NN cord-006856-b1w25ob5 988 28 and and CC cord-006856-b1w25ob5 988 29 recurrence recurrence NN cord-006856-b1w25ob5 988 30 of of IN cord-006856-b1w25ob5 988 31 autoimmune autoimmune JJ cord-006856-b1w25ob5 988 32 type type NN cord-006856-b1w25ob5 988 33 I -PRON- PRP cord-006856-b1w25ob5 988 34 diabetes diabete VBZ cord-006856-b1w25ob5 988 35 . . . cord-006856-b1w25ob5 989 1 In in IN cord-006856-b1w25ob5 989 2 recent recent JJ cord-006856-b1w25ob5 989 3 experiments experiment NNS cord-006856-b1w25ob5 989 4 we -PRON- PRP cord-006856-b1w25ob5 989 5 wanted want VBD cord-006856-b1w25ob5 989 6 to to TO cord-006856-b1w25ob5 989 7 investigate investigate VB cord-006856-b1w25ob5 989 8 the the DT cord-006856-b1w25ob5 989 9 role role NN cord-006856-b1w25ob5 989 10 of of IN cord-006856-b1w25ob5 989 11 NK NK NNP cord-006856-b1w25ob5 989 12 T T NNP cord-006856-b1w25ob5 989 13 cells cell NNS cord-006856-b1w25ob5 989 14 in in IN cord-006856-b1w25ob5 989 15 a a DT cord-006856-b1w25ob5 989 16 model model NN cord-006856-b1w25ob5 989 17 of of IN cord-006856-b1w25ob5 989 18 tolerance tolerance NN cord-006856-b1w25ob5 989 19 induction induction NN cord-006856-b1w25ob5 989 20 through through IN cord-006856-b1w25ob5 989 21 BMT BMT NNP cord-006856-b1w25ob5 989 22 with with IN cord-006856-b1w25ob5 989 23 costimulation costimulation NN cord-006856-b1w25ob5 989 24 blockade blockade NN cord-006856-b1w25ob5 989 25 . . . cord-006856-b1w25ob5 990 1 To to TO cord-006856-b1w25ob5 990 2 delineate delineate VB cord-006856-b1w25ob5 990 3 the the DT cord-006856-b1w25ob5 990 4 role role NN cord-006856-b1w25ob5 990 5 of of IN cord-006856-b1w25ob5 990 6 donor donor NN cord-006856-b1w25ob5 990 7 and and CC cord-006856-b1w25ob5 990 8 recipient recipient NN cord-006856-b1w25ob5 990 9 NK NK NNP cord-006856-b1w25ob5 990 10 T T NNP cord-006856-b1w25ob5 990 11 cells cell NNS cord-006856-b1w25ob5 990 12 , , , cord-006856-b1w25ob5 990 13 we -PRON- PRP cord-006856-b1w25ob5 990 14 used use VBD cord-006856-b1w25ob5 990 15 NK NK NNP cord-006856-b1w25ob5 990 16 - - HYPH cord-006856-b1w25ob5 990 17 T t NN cord-006856-b1w25ob5 990 18 - - HYPH cord-006856-b1w25ob5 990 19 cell cell NN cord-006856-b1w25ob5 990 20 - - HYPH cord-006856-b1w25ob5 990 21 deficient deficient JJ cord-006856-b1w25ob5 990 22 mice mouse NNS cord-006856-b1w25ob5 990 23 ( ( -LRB- cord-006856-b1w25ob5 990 24 Jα281-/-C57BL/6 Jα281-/-C57BL/6 NNP cord-006856-b1w25ob5 990 25 and and CC cord-006856-b1w25ob5 990 26 Jα281-/-BALB Jα281-/-BALB NNP cord-006856-b1w25ob5 990 27 / / SYM cord-006856-b1w25ob5 990 28 c c NN cord-006856-b1w25ob5 990 29 ) ) -RRB- cord-006856-b1w25ob5 990 30 as as IN cord-006856-b1w25ob5 990 31 recipient recipient NN cord-006856-b1w25ob5 990 32 and/or and/or CC cord-006856-b1w25ob5 990 33 donor donor NN cord-006856-b1w25ob5 990 34 strain strain NN cord-006856-b1w25ob5 990 35 . . . cord-006856-b1w25ob5 991 1 We -PRON- PRP cord-006856-b1w25ob5 991 2 also also RB cord-006856-b1w25ob5 991 3 evaluated evaluate VBD cord-006856-b1w25ob5 991 4 whether whether IN cord-006856-b1w25ob5 991 5 in in IN cord-006856-b1w25ob5 991 6 vivo vivo NN cord-006856-b1w25ob5 991 7 stimulation stimulation NN cord-006856-b1w25ob5 991 8 of of IN cord-006856-b1w25ob5 991 9 NK NK NNP cord-006856-b1w25ob5 991 10 T T NNP cord-006856-b1w25ob5 991 11 cells cell NNS cord-006856-b1w25ob5 991 12 with with IN cord-006856-b1w25ob5 991 13 α α NN cord-006856-b1w25ob5 991 14 - - HYPH cord-006856-b1w25ob5 991 15 Gal Gal NNP cord-006856-b1w25ob5 991 16 has have VBZ cord-006856-b1w25ob5 991 17 a a DT cord-006856-b1w25ob5 991 18 beneficial beneficial JJ cord-006856-b1w25ob5 991 19 effect effect NN cord-006856-b1w25ob5 991 20 . . . cord-006856-b1w25ob5 992 1 Methods method NNS cord-006856-b1w25ob5 992 2 . . . cord-006856-b1w25ob5 993 1 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 993 2 mice mouse NNS cord-006856-b1w25ob5 994 1 and and CC cord-006856-b1w25ob5 994 2 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 994 3 Jα281-/-received Jα281-/-received NNP cord-006856-b1w25ob5 995 1 a a DT cord-006856-b1w25ob5 995 2 total total JJ cord-006856-b1w25ob5 995 3 - - HYPH cord-006856-b1w25ob5 995 4 body body NN cord-006856-b1w25ob5 995 5 irradiation irradiation NN cord-006856-b1w25ob5 995 6 ( ( -LRB- cord-006856-b1w25ob5 995 7 TBI TBI NNP cord-006856-b1w25ob5 995 8 ) ) -RRB- cord-006856-b1w25ob5 995 9 of of IN cord-006856-b1w25ob5 995 10 3 3 CD cord-006856-b1w25ob5 995 11 Gy Gy NNP cord-006856-b1w25ob5 995 12 or or CC cord-006856-b1w25ob5 995 13 1 1 CD cord-006856-b1w25ob5 995 14 Gy Gy NNP cord-006856-b1w25ob5 995 15 ( ( -LRB- cord-006856-b1w25ob5 995 16 day day NN cord-006856-b1w25ob5 995 17 -1 -1 NNP cord-006856-b1w25ob5 995 18 ) ) -RRB- cord-006856-b1w25ob5 995 19 , , , cord-006856-b1w25ob5 995 20 approximately approximately RB cord-006856-b1w25ob5 995 21 20 20 CD cord-006856-b1w25ob5 995 22 × × NN cord-006856-b1w25ob5 996 1 10 10 CD cord-006856-b1w25ob5 996 2 6 6 CD cord-006856-b1w25ob5 996 3 fully fully RB cord-006856-b1w25ob5 996 4 mismatched mismatched JJ cord-006856-b1w25ob5 996 5 BALB BALB NNP cord-006856-b1w25ob5 996 6 / / SYM cord-006856-b1w25ob5 996 7 c c NN cord-006856-b1w25ob5 996 8 or or CC cord-006856-b1w25ob5 996 9 BALB BALB NNP cord-006856-b1w25ob5 997 1 /c /c JJ cord-006856-b1w25ob5 997 2 Jα281-/-bone Jα281-/-bone NNP cord-006856-b1w25ob5 997 3 marrow marrow NN cord-006856-b1w25ob5 997 4 cells cell NNS cord-006856-b1w25ob5 997 5 ( ( -LRB- cord-006856-b1w25ob5 997 6 day day NN cord-006856-b1w25ob5 997 7 0 0 CD cord-006856-b1w25ob5 997 8 ) ) -RRB- cord-006856-b1w25ob5 997 9 and and CC cord-006856-b1w25ob5 997 10 costimulation costimulation NN cord-006856-b1w25ob5 997 11 blockade blockade NN cord-006856-b1w25ob5 997 12 consisting consist VBG cord-006856-b1w25ob5 997 13 of of IN cord-006856-b1w25ob5 997 14 anti anti JJ cord-006856-b1w25ob5 997 15 - - JJ cord-006856-b1w25ob5 997 16 CD154 cd154 CD cord-006856-b1w25ob5 997 17 mAb mAb NNS cord-006856-b1w25ob5 997 18 ( ( -LRB- cord-006856-b1w25ob5 997 19 MR1 MR1 NNP cord-006856-b1w25ob5 997 20 , , , cord-006856-b1w25ob5 997 21 day day NN cord-006856-b1w25ob5 997 22 0 0 CD cord-006856-b1w25ob5 997 23 ) ) -RRB- cord-006856-b1w25ob5 997 24 and and CC cord-006856-b1w25ob5 997 25 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 997 26 ( ( -LRB- cord-006856-b1w25ob5 997 27 day day NN cord-006856-b1w25ob5 997 28 +2 +2 CD cord-006856-b1w25ob5 997 29 ) ) -RRB- cord-006856-b1w25ob5 997 30 . . . cord-006856-b1w25ob5 998 1 Groups group NNS cord-006856-b1w25ob5 998 2 were be VBD cord-006856-b1w25ob5 998 3 additionally additionally RB cord-006856-b1w25ob5 998 4 treated treat VBN cord-006856-b1w25ob5 998 5 with with IN cord-006856-b1w25ob5 998 6 α α NN cord-006856-b1w25ob5 998 7 - - HYPH cord-006856-b1w25ob5 998 8 Gal gal NN cord-006856-b1w25ob5 998 9 or or CC cord-006856-b1w25ob5 998 10 a a DT cord-006856-b1w25ob5 998 11 vehicle vehicle NN cord-006856-b1w25ob5 998 12 ( ( -LRB- cord-006856-b1w25ob5 998 13 5 5 CD cord-006856-b1w25ob5 998 14 µg µg NN cord-006856-b1w25ob5 998 15 on on IN cord-006856-b1w25ob5 998 16 day day NN cord-006856-b1w25ob5 998 17 -1 -1 CD cord-006856-b1w25ob5 998 18 , , , cord-006856-b1w25ob5 998 19 +2 +2 NNP cord-006856-b1w25ob5 998 20 , , , cord-006856-b1w25ob5 998 21 +7 +7 NN cord-006856-b1w25ob5 998 22 , , , cord-006856-b1w25ob5 998 23 +14 +14 CD cord-006856-b1w25ob5 998 24 , , , cord-006856-b1w25ob5 998 25 and and CC cord-006856-b1w25ob5 998 26 +21 +21 CD cord-006856-b1w25ob5 998 27 ) ) -RRB- cord-006856-b1w25ob5 998 28 . . . cord-006856-b1w25ob5 999 1 Multilinage multilinage NN cord-006856-b1w25ob5 999 2 chimerism chimerism NN cord-006856-b1w25ob5 999 3 and and CC cord-006856-b1w25ob5 999 4 skin skin NN cord-006856-b1w25ob5 999 5 graft graft NN cord-006856-b1w25ob5 999 6 survival survival NN cord-006856-b1w25ob5 999 7 were be VBD cord-006856-b1w25ob5 999 8 followed follow VBN cord-006856-b1w25ob5 999 9 for for IN cord-006856-b1w25ob5 999 10 more more JJR cord-006856-b1w25ob5 999 11 than than IN cord-006856-b1w25ob5 999 12 120 120 CD cord-006856-b1w25ob5 999 13 days day NNS cord-006856-b1w25ob5 999 14 . . . cord-006856-b1w25ob5 1000 1 Results result NNS cord-006856-b1w25ob5 1000 2 . . . cord-006856-b1w25ob5 1001 1 With with IN cord-006856-b1w25ob5 1001 2 our -PRON- PRP$ cord-006856-b1w25ob5 1001 3 standard standard JJ cord-006856-b1w25ob5 1001 4 protocol protocol NN cord-006856-b1w25ob5 1001 5 , , , cord-006856-b1w25ob5 1001 6 12 12 CD cord-006856-b1w25ob5 1001 7 of of IN cord-006856-b1w25ob5 1001 8 18 18 CD cord-006856-b1w25ob5 1001 9 mice mouse NNS cord-006856-b1w25ob5 1001 10 developed develop VBD cord-006856-b1w25ob5 1001 11 long long JJ cord-006856-b1w25ob5 1001 12 - - HYPH cord-006856-b1w25ob5 1001 13 term term NN cord-006856-b1w25ob5 1001 14 multilinage multilinage NN cord-006856-b1w25ob5 1001 15 chimerism chimerism NN cord-006856-b1w25ob5 1001 16 and and CC cord-006856-b1w25ob5 1001 17 permanent permanent JJ cord-006856-b1w25ob5 1001 18 donor donor NN cord-006856-b1w25ob5 1001 19 skin skin NN cord-006856-b1w25ob5 1001 20 graft graft NN cord-006856-b1w25ob5 1001 21 survival survival NN cord-006856-b1w25ob5 1001 22 . . . cord-006856-b1w25ob5 1002 1 When when WRB cord-006856-b1w25ob5 1002 2 using use VBG cord-006856-b1w25ob5 1002 3 recipients recipient NNS cord-006856-b1w25ob5 1002 4 deficient deficient JJ cord-006856-b1w25ob5 1002 5 in in IN cord-006856-b1w25ob5 1002 6 NKT NKT NNP cord-006856-b1w25ob5 1002 7 cells cell NNS cord-006856-b1w25ob5 1002 8 , , , cord-006856-b1w25ob5 1002 9 5 5 CD cord-006856-b1w25ob5 1002 10 of of IN cord-006856-b1w25ob5 1002 11 5 5 CD cord-006856-b1w25ob5 1002 12 became become VBD cord-006856-b1w25ob5 1002 13 chimeric chimeric JJ cord-006856-b1w25ob5 1002 14 and and CC cord-006856-b1w25ob5 1002 15 showed show VBD cord-006856-b1w25ob5 1002 16 long long JJ cord-006856-b1w25ob5 1002 17 - - HYPH cord-006856-b1w25ob5 1002 18 term term NN cord-006856-b1w25ob5 1002 19 skin skin NN cord-006856-b1w25ob5 1002 20 graft graft NN cord-006856-b1w25ob5 1002 21 survival survival NN cord-006856-b1w25ob5 1002 22 ; ; : cord-006856-b1w25ob5 1002 23 using use VBG cord-006856-b1w25ob5 1002 24 NKT NKT NNP cord-006856-b1w25ob5 1002 25 knockouts knockout NNS cord-006856-b1w25ob5 1002 26 as as IN cord-006856-b1w25ob5 1002 27 donors donor NNS cord-006856-b1w25ob5 1002 28 6 6 CD cord-006856-b1w25ob5 1002 29 of of IN cord-006856-b1w25ob5 1002 30 6 6 CD cord-006856-b1w25ob5 1002 31 and and CC cord-006856-b1w25ob5 1002 32 using use VBG cord-006856-b1w25ob5 1002 33 NKT NKT NNP cord-006856-b1w25ob5 1002 34 knockouts knockout NNS cord-006856-b1w25ob5 1002 35 both both DT cord-006856-b1w25ob5 1002 36 as as IN cord-006856-b1w25ob5 1002 37 recipients recipient NNS cord-006856-b1w25ob5 1002 38 and and CC cord-006856-b1w25ob5 1002 39 donors donor NNS cord-006856-b1w25ob5 1002 40 5 5 CD cord-006856-b1w25ob5 1002 41 of of IN cord-006856-b1w25ob5 1002 42 6 6 CD cord-006856-b1w25ob5 1002 43 became become VBD cord-006856-b1w25ob5 1002 44 chimeric chimeric JJ cord-006856-b1w25ob5 1003 1 ( ( -LRB- cord-006856-b1w25ob5 1003 2 P p NN cord-006856-b1w25ob5 1003 3 = = SYM cord-006856-b1w25ob5 1003 4 n.s n.s NNP cord-006856-b1w25ob5 1003 5 . . . cord-006856-b1w25ob5 1004 1 for for IN cord-006856-b1w25ob5 1004 2 all all DT cord-006856-b1w25ob5 1004 3 comparisons comparison NNS cord-006856-b1w25ob5 1004 4 ) ) -RRB- cord-006856-b1w25ob5 1004 5 . . . cord-006856-b1w25ob5 1005 1 Unexpectedly unexpectedly RB cord-006856-b1w25ob5 1005 2 , , , cord-006856-b1w25ob5 1005 3 stimulation stimulation NN cord-006856-b1w25ob5 1005 4 of of IN cord-006856-b1w25ob5 1005 5 NK NK NNP cord-006856-b1w25ob5 1005 6 T T NNP cord-006856-b1w25ob5 1005 7 cells cell NNS cord-006856-b1w25ob5 1005 8 by by IN cord-006856-b1w25ob5 1005 9 α α NN cord-006856-b1w25ob5 1005 10 - - HYPH cord-006856-b1w25ob5 1005 11 Gal Gal NNP cord-006856-b1w25ob5 1005 12 ( ( -LRB- cord-006856-b1w25ob5 1005 13 using use VBG cord-006856-b1w25ob5 1005 14 wild wild JJ cord-006856-b1w25ob5 1005 15 - - HYPH cord-006856-b1w25ob5 1005 16 type type NN cord-006856-b1w25ob5 1005 17 recipients recipient NNS cord-006856-b1w25ob5 1005 18 and and CC cord-006856-b1w25ob5 1005 19 donors donor NNS cord-006856-b1w25ob5 1005 20 ) ) -RRB- cord-006856-b1w25ob5 1005 21 prevented prevent VBD cord-006856-b1w25ob5 1005 22 chimerism chimerism NN cord-006856-b1w25ob5 1005 23 induction induction NN cord-006856-b1w25ob5 1005 24 after after IN cord-006856-b1w25ob5 1005 25 3 3 CD cord-006856-b1w25ob5 1005 26 Gy Gy NNP cord-006856-b1w25ob5 1005 27 TBI TBI NNP cord-006856-b1w25ob5 1005 28 ( ( -LRB- cord-006856-b1w25ob5 1005 29 0 0 CD cord-006856-b1w25ob5 1005 30 of of IN cord-006856-b1w25ob5 1005 31 8 8 CD cord-006856-b1w25ob5 1005 32 vs. vs. NN cord-006856-b1w25ob5 1005 33 4 4 CD cord-006856-b1w25ob5 1005 34 of of IN cord-006856-b1w25ob5 1005 35 6 6 CD cord-006856-b1w25ob5 1005 36 and and CC cord-006856-b1w25ob5 1005 37 4 4 CD cord-006856-b1w25ob5 1005 38 of of IN cord-006856-b1w25ob5 1005 39 4 4 CD cord-006856-b1w25ob5 1005 40 in in IN cord-006856-b1w25ob5 1005 41 the the DT cord-006856-b1w25ob5 1005 42 vehicle vehicle NN cord-006856-b1w25ob5 1005 43 group group NN cord-006856-b1w25ob5 1005 44 , , , cord-006856-b1w25ob5 1005 45 P p NN cord-006856-b1w25ob5 1005 46 < < XX cord-006856-b1w25ob5 1005 47 0.01 0.01 CD cord-006856-b1w25ob5 1005 48 ) ) -RRB- cord-006856-b1w25ob5 1005 49 and and CC cord-006856-b1w25ob5 1005 50 did do VBD cord-006856-b1w25ob5 1005 51 not not RB cord-006856-b1w25ob5 1005 52 promote promote VB cord-006856-b1w25ob5 1005 53 engraftment engraftment NN cord-006856-b1w25ob5 1005 54 after after IN cord-006856-b1w25ob5 1005 55 1 1 CD cord-006856-b1w25ob5 1005 56 Gy Gy NNP cord-006856-b1w25ob5 1005 57 TBI TBI NNP cord-006856-b1w25ob5 1005 58 ( ( -LRB- cord-006856-b1w25ob5 1005 59 0 0 CD cord-006856-b1w25ob5 1005 60 of of IN cord-006856-b1w25ob5 1005 61 8 8 CD cord-006856-b1w25ob5 1005 62 vs. vs. NN cord-006856-b1w25ob5 1005 63 0 0 CD cord-006856-b1w25ob5 1005 64 of of IN cord-006856-b1w25ob5 1005 65 8) 8) NN cord-006856-b1w25ob5 1005 66 . . . cord-006856-b1w25ob5 1006 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1006 2 . . . cord-006856-b1w25ob5 1007 1 NK NK NNP cord-006856-b1w25ob5 1007 2 T T NNP cord-006856-b1w25ob5 1007 3 cells cell NNS cord-006856-b1w25ob5 1007 4 do do VBP cord-006856-b1w25ob5 1007 5 not not RB cord-006856-b1w25ob5 1007 6 play play VB cord-006856-b1w25ob5 1007 7 a a DT cord-006856-b1w25ob5 1007 8 critical critical JJ cord-006856-b1w25ob5 1007 9 role role NN cord-006856-b1w25ob5 1007 10 in in IN cord-006856-b1w25ob5 1007 11 tolerance tolerance NN cord-006856-b1w25ob5 1007 12 induction induction NN cord-006856-b1w25ob5 1007 13 after after IN cord-006856-b1w25ob5 1007 14 BMT BMT NNP cord-006856-b1w25ob5 1007 15 with with IN cord-006856-b1w25ob5 1007 16 costimulation costimulation NN cord-006856-b1w25ob5 1007 17 blockade blockade NN cord-006856-b1w25ob5 1007 18 . . . cord-006856-b1w25ob5 1008 1 Their -PRON- PRP$ cord-006856-b1w25ob5 1008 2 stimulation stimulation NN cord-006856-b1w25ob5 1008 3 with with IN cord-006856-b1w25ob5 1008 4 α α NN cord-006856-b1w25ob5 1008 5 - - HYPH cord-006856-b1w25ob5 1008 6 Gal Gal NNP cord-006856-b1w25ob5 1008 7 even even RB cord-006856-b1w25ob5 1008 8 prevents prevent VBZ cord-006856-b1w25ob5 1008 9 induction induction NN cord-006856-b1w25ob5 1008 10 of of IN cord-006856-b1w25ob5 1008 11 mixed mixed JJ cord-006856-b1w25ob5 1008 12 chimerism chimerism NN cord-006856-b1w25ob5 1008 13 and and CC cord-006856-b1w25ob5 1008 14 tolerance tolerance NN cord-006856-b1w25ob5 1008 15 . . . cord-006856-b1w25ob5 1009 1 Background background NN cord-006856-b1w25ob5 1009 2 . . . cord-006856-b1w25ob5 1010 1 Phospholamban Phospholamban NNP cord-006856-b1w25ob5 1010 2 ( ( -LRB- cord-006856-b1w25ob5 1010 3 PLB PLB NNP cord-006856-b1w25ob5 1010 4 ) ) -RRB- cord-006856-b1w25ob5 1010 5 is be VBZ cord-006856-b1w25ob5 1010 6 a a DT cord-006856-b1w25ob5 1010 7 critical critical JJ cord-006856-b1w25ob5 1010 8 regulator regulator NN cord-006856-b1w25ob5 1010 9 of of IN cord-006856-b1w25ob5 1010 10 sarcoplasmic sarcoplasmic JJ cord-006856-b1w25ob5 1010 11 reticulum reticulum NN cord-006856-b1w25ob5 1011 1 Ca ca NN cord-006856-b1w25ob5 1011 2 2 2 CD cord-006856-b1w25ob5 1011 3 + + CD cord-006856-b1w25ob5 1012 1 -ATPase -ATPase NNP cord-006856-b1w25ob5 1012 2 activity activity NN cord-006856-b1w25ob5 1012 3 and and CC cord-006856-b1w25ob5 1012 4 myocardial myocardial JJ cord-006856-b1w25ob5 1012 5 contractility contractility NN cord-006856-b1w25ob5 1012 6 . . . cord-006856-b1w25ob5 1013 1 In in IN cord-006856-b1w25ob5 1013 2 this this DT cord-006856-b1w25ob5 1013 3 study study NN cord-006856-b1w25ob5 1013 4 we -PRON- PRP cord-006856-b1w25ob5 1013 5 investigated investigate VBD cord-006856-b1w25ob5 1013 6 the the DT cord-006856-b1w25ob5 1013 7 role role NN cord-006856-b1w25ob5 1013 8 of of IN cord-006856-b1w25ob5 1013 9 PLB PLB NNP cord-006856-b1w25ob5 1013 10 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1013 11 in in IN cord-006856-b1w25ob5 1013 12 ischemia ischemia NN cord-006856-b1w25ob5 1013 13 and and CC cord-006856-b1w25ob5 1013 14 reperfusion reperfusion NN cord-006856-b1w25ob5 1013 15 following follow VBG cord-006856-b1w25ob5 1013 16 cardiac cardiac JJ cord-006856-b1w25ob5 1013 17 transplantation transplantation NN cord-006856-b1w25ob5 1013 18 . . . cord-006856-b1w25ob5 1014 1 Methods method NNS cord-006856-b1w25ob5 1014 2 . . . cord-006856-b1w25ob5 1015 1 Gene gene NN cord-006856-b1w25ob5 1015 2 expression expression NN cord-006856-b1w25ob5 1015 3 of of IN cord-006856-b1w25ob5 1015 4 PLB PLB NNP cord-006856-b1w25ob5 1015 5 was be VBD cord-006856-b1w25ob5 1015 6 investigated investigate VBN cord-006856-b1w25ob5 1015 7 in in IN cord-006856-b1w25ob5 1015 8 a a DT cord-006856-b1w25ob5 1015 9 syngeneic syngeneic NNS cord-006856-b1w25ob5 1015 10 heterotopic heterotopic NNP cord-006856-b1w25ob5 1015 11 cardiac cardiac JJ cord-006856-b1w25ob5 1015 12 transplant transplant NN cord-006856-b1w25ob5 1015 13 model model NN cord-006856-b1w25ob5 1015 14 in in IN cord-006856-b1w25ob5 1015 15 mice mouse NNS cord-006856-b1w25ob5 1015 16 . . . cord-006856-b1w25ob5 1016 1 Grafts graft NNS cord-006856-b1w25ob5 1016 2 underwent undergo VBD cord-006856-b1w25ob5 1016 3 10 10 CD cord-006856-b1w25ob5 1016 4 h h NN cord-006856-b1w25ob5 1016 5 of of IN cord-006856-b1w25ob5 1016 6 cold cold JJ cord-006856-b1w25ob5 1016 7 ischemia ischemia NN cord-006856-b1w25ob5 1016 8 or or CC cord-006856-b1w25ob5 1016 9 were be VBD cord-006856-b1w25ob5 1016 10 tranplanted tranplante VBN cord-006856-b1w25ob5 1016 11 immediately immediately RB cord-006856-b1w25ob5 1016 12 after after IN cord-006856-b1w25ob5 1016 13 harvest harvest NN cord-006856-b1w25ob5 1016 14 . . . cord-006856-b1w25ob5 1017 1 Gene gene NN cord-006856-b1w25ob5 1017 2 expression expression NN cord-006856-b1w25ob5 1017 3 was be VBD cord-006856-b1w25ob5 1017 4 analysed analyse VBN cord-006856-b1w25ob5 1017 5 at at IN cord-006856-b1w25ob5 1017 6 various various JJ cord-006856-b1w25ob5 1017 7 time time NN cord-006856-b1w25ob5 1017 8 points point NNS cord-006856-b1w25ob5 1017 9 employing employ VBG cord-006856-b1w25ob5 1017 10 DNA dna NN cord-006856-b1w25ob5 1017 11 microarray microarray NN cord-006856-b1w25ob5 1017 12 and and CC cord-006856-b1w25ob5 1017 13 RT RT NNP cord-006856-b1w25ob5 1017 14 - - HYPH cord-006856-b1w25ob5 1017 15 PCR PCR NNP cord-006856-b1w25ob5 1017 16 . . . cord-006856-b1w25ob5 1018 1 For for IN cord-006856-b1w25ob5 1018 2 in in IN cord-006856-b1w25ob5 1018 3 vitro vitro FW cord-006856-b1w25ob5 1018 4 experiments experiment NNS cord-006856-b1w25ob5 1018 5 , , , cord-006856-b1w25ob5 1018 6 HL-1 HL-1 NNP cord-006856-b1w25ob5 1018 7 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1018 8 were be VBD cord-006856-b1w25ob5 1018 9 submitted submit VBN cord-006856-b1w25ob5 1018 10 to to IN cord-006856-b1w25ob5 1018 11 a a DT cord-006856-b1w25ob5 1018 12 protocol protocol NN cord-006856-b1w25ob5 1018 13 of of IN cord-006856-b1w25ob5 1018 14 global global JJ cord-006856-b1w25ob5 1018 15 normothermic normothermic JJ cord-006856-b1w25ob5 1018 16 hypoxia hypoxia NN cord-006856-b1w25ob5 1018 17 for for IN cord-006856-b1w25ob5 1018 18 6 6 CD cord-006856-b1w25ob5 1018 19 h h NN cord-006856-b1w25ob5 1018 20 and and CC cord-006856-b1w25ob5 1018 21 reoxygenation reoxygenation NN cord-006856-b1w25ob5 1018 22 in in IN cord-006856-b1w25ob5 1018 23 the the DT cord-006856-b1w25ob5 1018 24 absence absence NN cord-006856-b1w25ob5 1018 25 or or CC cord-006856-b1w25ob5 1018 26 presence presence NN cord-006856-b1w25ob5 1018 27 of of IN cord-006856-b1w25ob5 1018 28 the the DT cord-006856-b1w25ob5 1019 1 Ca ca NN cord-006856-b1w25ob5 1019 2 2 2 CD cord-006856-b1w25ob5 1019 3 + + CD cord-006856-b1w25ob5 1020 1 /calmodulin /calmodulin , cord-006856-b1w25ob5 1020 2 kinase kinase NN cord-006856-b1w25ob5 1020 3 II II NNP cord-006856-b1w25ob5 1020 4 inhibitor inhibitor NN cord-006856-b1w25ob5 1020 5 AIP AIP NNP cord-006856-b1w25ob5 1020 6 ( ( -LRB- cord-006856-b1w25ob5 1020 7 1 1 CD cord-006856-b1w25ob5 1020 8 µM µm CD cord-006856-b1w25ob5 1020 9 ) ) -RRB- cord-006856-b1w25ob5 1020 10 or or CC cord-006856-b1w25ob5 1020 11 the the DT cord-006856-b1w25ob5 1020 12 beta beta JJ cord-006856-b1w25ob5 1020 13 - - HYPH cord-006856-b1w25ob5 1020 14 adrenergic adrenergic NN cord-006856-b1w25ob5 1020 15 blocker blocker NN cord-006856-b1w25ob5 1020 16 dl dl NN cord-006856-b1w25ob5 1020 17 - - HYPH cord-006856-b1w25ob5 1020 18 propranolol propranolol NNP cord-006856-b1w25ob5 1020 19 ( ( -LRB- cord-006856-b1w25ob5 1020 20 1 1 CD cord-006856-b1w25ob5 1020 21 µM µm NN cord-006856-b1w25ob5 1020 22 ) ) -RRB- cord-006856-b1w25ob5 1020 23 vs. vs. IN cord-006856-b1w25ob5 1020 24 beta beta JJ cord-006856-b1w25ob5 1020 25 - - HYPH cord-006856-b1w25ob5 1020 26 adrenergic adrenergic JJ cord-006856-b1w25ob5 1020 27 stimulator stimulator NN cord-006856-b1w25ob5 1020 28 isoproterenol isoproterenol NNP cord-006856-b1w25ob5 1020 29 ( ( -LRB- cord-006856-b1w25ob5 1020 30 1 1 CD cord-006856-b1w25ob5 1020 31 µM µm CD cord-006856-b1w25ob5 1020 32 ) ) -RRB- cord-006856-b1w25ob5 1020 33 . . . cord-006856-b1w25ob5 1021 1 Results result NNS cord-006856-b1w25ob5 1021 2 . . . cord-006856-b1w25ob5 1022 1 At at IN cord-006856-b1w25ob5 1022 2 24 24 CD cord-006856-b1w25ob5 1022 3 h h NN cord-006856-b1w25ob5 1022 4 , , , cord-006856-b1w25ob5 1022 5 gene gene NN cord-006856-b1w25ob5 1022 6 expression expression NN cord-006856-b1w25ob5 1022 7 of of IN cord-006856-b1w25ob5 1022 8 PLB PLB NNP cord-006856-b1w25ob5 1022 9 was be VBD cord-006856-b1w25ob5 1022 10 diminished diminish VBN cord-006856-b1w25ob5 1022 11 by by IN cord-006856-b1w25ob5 1022 12 14.1 14.1 CD cord-006856-b1w25ob5 1022 13 and and CC cord-006856-b1w25ob5 1022 14 3.6-fold 3.6-fold CD cord-006856-b1w25ob5 1022 15 in in IN cord-006856-b1w25ob5 1022 16 groups group NNS cord-006856-b1w25ob5 1022 17 with with IN cord-006856-b1w25ob5 1022 18 and and CC cord-006856-b1w25ob5 1022 19 without without IN cord-006856-b1w25ob5 1022 20 ischemia ischemia NN cord-006856-b1w25ob5 1022 21 , , , cord-006856-b1w25ob5 1022 22 respectively respectively RB cord-006856-b1w25ob5 1022 23 . . . cord-006856-b1w25ob5 1023 1 Basal basal NN cord-006856-b1w25ob5 1023 2 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1023 3 of of IN cord-006856-b1w25ob5 1023 4 PLB PLB NNP cord-006856-b1w25ob5 1023 5 at at IN cord-006856-b1w25ob5 1023 6 Ser16 Ser16 NNP cord-006856-b1w25ob5 1024 1 ( ( -LRB- cord-006856-b1w25ob5 1024 2 protein protein NN cord-006856-b1w25ob5 1024 3 kinase kinase VBZ cord-006856-b1w25ob5 1024 4 A a DT cord-006856-b1w25ob5 1024 5 site site NN cord-006856-b1w25ob5 1024 6 ) ) -RRB- cord-006856-b1w25ob5 1024 7 and and CC cord-006856-b1w25ob5 1024 8 at at IN cord-006856-b1w25ob5 1024 9 Thr17 Thr17 NNP cord-006856-b1w25ob5 1025 1 ( ( -LRB- cord-006856-b1w25ob5 1025 2 Ca Ca NNP cord-006856-b1w25ob5 1025 3 2 2 CD cord-006856-b1w25ob5 1025 4 + + CC cord-006856-b1w25ob5 1025 5 /calmodulin /calmodulin . cord-006856-b1w25ob5 1025 6 kinase kinase NN cord-006856-b1w25ob5 1025 7 II ii CD cord-006856-b1w25ob5 1025 8 site site NN cord-006856-b1w25ob5 1025 9 ) ) -RRB- cord-006856-b1w25ob5 1025 10 was be VBD cord-006856-b1w25ob5 1025 11 present present JJ cord-006856-b1w25ob5 1025 12 in in IN cord-006856-b1w25ob5 1025 13 cultured cultured JJ cord-006856-b1w25ob5 1025 14 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1025 15 and and CC cord-006856-b1w25ob5 1025 16 heart heart NN cord-006856-b1w25ob5 1025 17 lysates lysate NNS cord-006856-b1w25ob5 1025 18 . . . cord-006856-b1w25ob5 1026 1 In in IN cord-006856-b1w25ob5 1026 2 the the DT cord-006856-b1w25ob5 1026 3 mouse mouse NN cord-006856-b1w25ob5 1026 4 system system NN cord-006856-b1w25ob5 1026 5 , , , cord-006856-b1w25ob5 1026 6 increase increase VBP cord-006856-b1w25ob5 1026 7 in in IN cord-006856-b1w25ob5 1026 8 PLB PLB NNP cord-006856-b1w25ob5 1026 9 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1026 10 is be VBZ cord-006856-b1w25ob5 1026 11 observed observe VBN cord-006856-b1w25ob5 1026 12 during during IN cord-006856-b1w25ob5 1026 13 early early RB cord-006856-b1w25ob5 1026 14 ( ( -LRB- cord-006856-b1w25ob5 1026 15 up up IN cord-006856-b1w25ob5 1026 16 to to TO cord-006856-b1w25ob5 1026 17 10 10 CD cord-006856-b1w25ob5 1026 18 min min NN cord-006856-b1w25ob5 1026 19 ) ) -RRB- cord-006856-b1w25ob5 1026 20 reperfusion reperfusion NN cord-006856-b1w25ob5 1026 21 . . . cord-006856-b1w25ob5 1027 1 Thereafter thereafter RB cord-006856-b1w25ob5 1027 2 , , , cord-006856-b1w25ob5 1027 3 PLB PLB NNP cord-006856-b1w25ob5 1027 4 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1027 5 drops drop VBZ cord-006856-b1w25ob5 1027 6 below below IN cord-006856-b1w25ob5 1027 7 that that DT cord-006856-b1w25ob5 1027 8 of of IN cord-006856-b1w25ob5 1027 9 control control NN cord-006856-b1w25ob5 1027 10 levels level NNS cord-006856-b1w25ob5 1027 11 . . . cord-006856-b1w25ob5 1028 1 Addition addition NN cord-006856-b1w25ob5 1028 2 of of IN cord-006856-b1w25ob5 1028 3 AIP AIP NNP cord-006856-b1w25ob5 1028 4 diminishes diminish VBZ cord-006856-b1w25ob5 1028 5 reperfusion reperfusion NN cord-006856-b1w25ob5 1028 6 - - HYPH cord-006856-b1w25ob5 1028 7 induced induce VBN cord-006856-b1w25ob5 1028 8 Thr17 Thr17 NNP cord-006856-b1w25ob5 1028 9 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1028 10 ; ; : cord-006856-b1w25ob5 1028 11 Propranolol propranolol NN cord-006856-b1w25ob5 1028 12 significantly significantly RB cord-006856-b1w25ob5 1028 13 decreases decrease VBZ cord-006856-b1w25ob5 1028 14 ischemia ischemia NN cord-006856-b1w25ob5 1028 15 - - HYPH cord-006856-b1w25ob5 1028 16 induced induce VBN cord-006856-b1w25ob5 1028 17 Ser16 Ser16 NNP cord-006856-b1w25ob5 1028 18 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1028 19 . . . cord-006856-b1w25ob5 1029 1 In in IN cord-006856-b1w25ob5 1029 2 contrast contrast NN cord-006856-b1w25ob5 1029 3 , , , cord-006856-b1w25ob5 1029 4 isoproterenol isoproterenol NNP cord-006856-b1w25ob5 1029 5 enhances enhance VBZ cord-006856-b1w25ob5 1029 6 PLB PLB NNP cord-006856-b1w25ob5 1029 7 - - HYPH cord-006856-b1w25ob5 1029 8 Ser16 Ser16 NNP cord-006856-b1w25ob5 1029 9 and and CC cord-006856-b1w25ob5 1029 10 Thr17 Thr17 NNP cord-006856-b1w25ob5 1029 11 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1029 12 . . . cord-006856-b1w25ob5 1030 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1030 2 . . . cord-006856-b1w25ob5 1031 1 Ischemia ischemia NN cord-006856-b1w25ob5 1031 2 regulates regulate VBZ cord-006856-b1w25ob5 1031 3 phospholamban phospholamban NNS cord-006856-b1w25ob5 1031 4 by by IN cord-006856-b1w25ob5 1031 5 two two CD cord-006856-b1w25ob5 1031 6 different different JJ cord-006856-b1w25ob5 1031 7 mechanisms mechanism NNS cord-006856-b1w25ob5 1031 8 , , , cord-006856-b1w25ob5 1031 9 decrease decrease VBP cord-006856-b1w25ob5 1031 10 in in IN cord-006856-b1w25ob5 1031 11 expression expression NN cord-006856-b1w25ob5 1031 12 levels level NNS cord-006856-b1w25ob5 1031 13 and and CC cord-006856-b1w25ob5 1031 14 alterations alteration NNS cord-006856-b1w25ob5 1031 15 in in IN cord-006856-b1w25ob5 1031 16 the the DT cord-006856-b1w25ob5 1031 17 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1031 18 of of IN cord-006856-b1w25ob5 1031 19 critical critical JJ cord-006856-b1w25ob5 1031 20 regulatory regulatory JJ cord-006856-b1w25ob5 1031 21 sites site NNS cord-006856-b1w25ob5 1031 22 . . . cord-006856-b1w25ob5 1032 1 Modulation modulation NN cord-006856-b1w25ob5 1032 2 by by IN cord-006856-b1w25ob5 1032 3 AIP AIP NNP cord-006856-b1w25ob5 1032 4 and and CC cord-006856-b1w25ob5 1032 5 dl dl NN cord-006856-b1w25ob5 1032 6 - - NNS cord-006856-b1w25ob5 1032 7 propranolol propranolol NNP cord-006856-b1w25ob5 1032 8 will will MD cord-006856-b1w25ob5 1032 9 help help VB cord-006856-b1w25ob5 1032 10 for for IN cord-006856-b1w25ob5 1032 11 investigation investigation NN cord-006856-b1w25ob5 1032 12 of of IN cord-006856-b1w25ob5 1032 13 the the DT cord-006856-b1w25ob5 1032 14 role role NN cord-006856-b1w25ob5 1032 15 of of IN cord-006856-b1w25ob5 1032 16 PBL PBL NNP cord-006856-b1w25ob5 1032 17 phosphorylation phosphorylation NN cord-006856-b1w25ob5 1032 18 in in IN cord-006856-b1w25ob5 1032 19 ischemia ischemia NN cord-006856-b1w25ob5 1032 20 and and CC cord-006856-b1w25ob5 1032 21 reperfusion reperfusion NN cord-006856-b1w25ob5 1032 22 in in IN cord-006856-b1w25ob5 1032 23 cardiac cardiac JJ cord-006856-b1w25ob5 1032 24 transplantation transplantation NN cord-006856-b1w25ob5 1032 25 in in IN cord-006856-b1w25ob5 1032 26 the the DT cord-006856-b1w25ob5 1032 27 future future NN cord-006856-b1w25ob5 1032 28 . . . cord-006856-b1w25ob5 1033 1 Background background NN cord-006856-b1w25ob5 1033 2 . . . cord-006856-b1w25ob5 1034 1 The the DT cord-006856-b1w25ob5 1034 2 p38 p38 CD cord-006856-b1w25ob5 1034 3 mitogen mitogen NN cord-006856-b1w25ob5 1034 4 - - HYPH cord-006856-b1w25ob5 1034 5 activated activate VBN cord-006856-b1w25ob5 1034 6 protein protein NN cord-006856-b1w25ob5 1034 7 kinase kinase NN cord-006856-b1w25ob5 1034 8 ( ( -LRB- cord-006856-b1w25ob5 1034 9 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1034 10 ) ) -RRB- cord-006856-b1w25ob5 1034 11 pathway pathway NN cord-006856-b1w25ob5 1034 12 plays play VBZ cord-006856-b1w25ob5 1034 13 a a DT cord-006856-b1w25ob5 1034 14 crucial crucial JJ cord-006856-b1w25ob5 1034 15 role role NN cord-006856-b1w25ob5 1034 16 in in IN cord-006856-b1w25ob5 1034 17 pathological pathological JJ cord-006856-b1w25ob5 1034 18 events event NNS cord-006856-b1w25ob5 1034 19 like like IN cord-006856-b1w25ob5 1034 20 oxidative oxidative JJ cord-006856-b1w25ob5 1034 21 stress stress NN cord-006856-b1w25ob5 1034 22 , , , cord-006856-b1w25ob5 1034 23 inflammation inflammation NN cord-006856-b1w25ob5 1034 24 , , , cord-006856-b1w25ob5 1034 25 and and CC cord-006856-b1w25ob5 1034 26 abnormal abnormal JJ cord-006856-b1w25ob5 1034 27 cellular cellular JJ cord-006856-b1w25ob5 1034 28 proliferation proliferation NN cord-006856-b1w25ob5 1034 29 , , , cord-006856-b1w25ob5 1034 30 resulting result VBG cord-006856-b1w25ob5 1034 31 in in IN cord-006856-b1w25ob5 1034 32 activation activation NN cord-006856-b1w25ob5 1034 33 of of IN cord-006856-b1w25ob5 1034 34 several several JJ cord-006856-b1w25ob5 1034 35 signalling signalling NN cord-006856-b1w25ob5 1034 36 cascades cascade NNS cord-006856-b1w25ob5 1034 37 , , , cord-006856-b1w25ob5 1034 38 involving involve VBG cord-006856-b1w25ob5 1034 39 overexpression overexpression NN cord-006856-b1w25ob5 1034 40 of of IN cord-006856-b1w25ob5 1034 41 tumor tumor NN cord-006856-b1w25ob5 1034 42 necrosis necrosis NN cord-006856-b1w25ob5 1034 43 factor factor NN cord-006856-b1w25ob5 1034 44 alpha alpha NN cord-006856-b1w25ob5 1034 45 ( ( -LRB- cord-006856-b1w25ob5 1034 46 TNF TNF NNP cord-006856-b1w25ob5 1034 47 - - HYPH cord-006856-b1w25ob5 1034 48 α α NNP cord-006856-b1w25ob5 1034 49 ) ) -RRB- cord-006856-b1w25ob5 1034 50 . . . cord-006856-b1w25ob5 1035 1 TNF TNF NNP cord-006856-b1w25ob5 1035 2 - - HYPH cord-006856-b1w25ob5 1035 3 α α NNP cord-006856-b1w25ob5 1035 4 is be VBZ cord-006856-b1w25ob5 1035 5 known know VBN cord-006856-b1w25ob5 1035 6 to to TO cord-006856-b1w25ob5 1035 7 play play VB cord-006856-b1w25ob5 1035 8 an an DT cord-006856-b1w25ob5 1035 9 important important JJ cord-006856-b1w25ob5 1035 10 role role NN cord-006856-b1w25ob5 1035 11 in in IN cord-006856-b1w25ob5 1035 12 chronic chronic JJ cord-006856-b1w25ob5 1035 13 rejection rejection NN cord-006856-b1w25ob5 1035 14 . . . cord-006856-b1w25ob5 1036 1 Currently currently RB cord-006856-b1w25ob5 1036 2 , , , cord-006856-b1w25ob5 1036 3 pharmacological pharmacological JJ cord-006856-b1w25ob5 1036 4 inhibitors inhibitor NNS cord-006856-b1w25ob5 1036 5 of of IN cord-006856-b1w25ob5 1036 6 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1036 7 are be VBP cord-006856-b1w25ob5 1036 8 being be VBG cord-006856-b1w25ob5 1036 9 tested test VBN cord-006856-b1w25ob5 1036 10 clinically clinically RB cord-006856-b1w25ob5 1036 11 for for IN cord-006856-b1w25ob5 1036 12 the the DT cord-006856-b1w25ob5 1036 13 treatment treatment NN cord-006856-b1w25ob5 1036 14 of of IN cord-006856-b1w25ob5 1036 15 Experimentelle Experimentelle NNP cord-006856-b1w25ob5 1036 16 Transplantation Transplantation NNP cord-006856-b1w25ob5 1036 17 chronic chronic JJ cord-006856-b1w25ob5 1036 18 inflammatory inflammatory JJ cord-006856-b1w25ob5 1036 19 diseases disease NNS cord-006856-b1w25ob5 1036 20 such such JJ cord-006856-b1w25ob5 1036 21 as as IN cord-006856-b1w25ob5 1036 22 rheumatoid rheumatoid JJ cord-006856-b1w25ob5 1036 23 arthritis arthritis NN cord-006856-b1w25ob5 1036 24 , , , cord-006856-b1w25ob5 1036 25 Morbus Morbus NNP cord-006856-b1w25ob5 1036 26 Crohn Crohn NNP cord-006856-b1w25ob5 1036 27 and and CC cord-006856-b1w25ob5 1036 28 psoriasis psoriasis NN cord-006856-b1w25ob5 1036 29 as as RB cord-006856-b1w25ob5 1036 30 well well RB cord-006856-b1w25ob5 1036 31 as as IN cord-006856-b1w25ob5 1036 32 inhibition inhibition NN cord-006856-b1w25ob5 1036 33 of of IN cord-006856-b1w25ob5 1036 34 vascular vascular JJ cord-006856-b1w25ob5 1036 35 smooth smooth JJ cord-006856-b1w25ob5 1036 36 muscle muscle NN cord-006856-b1w25ob5 1036 37 cell cell NN cord-006856-b1w25ob5 1036 38 ( ( -LRB- cord-006856-b1w25ob5 1036 39 VSMC VSMC NNP cord-006856-b1w25ob5 1036 40 ) ) -RRB- cord-006856-b1w25ob5 1036 41 proliferation proliferation NN cord-006856-b1w25ob5 1036 42 after after IN cord-006856-b1w25ob5 1036 43 balloon balloon NN cord-006856-b1w25ob5 1036 44 angioplasty angioplasty NN cord-006856-b1w25ob5 1036 45 . . . cord-006856-b1w25ob5 1037 1 To to IN cord-006856-b1w25ob5 1037 2 date date NN cord-006856-b1w25ob5 1037 3 , , , cord-006856-b1w25ob5 1037 4 there there EX cord-006856-b1w25ob5 1037 5 are be VBP cord-006856-b1w25ob5 1037 6 no no DT cord-006856-b1w25ob5 1037 7 findings finding NNS cord-006856-b1w25ob5 1037 8 that that WDT cord-006856-b1w25ob5 1037 9 address address VBP cord-006856-b1w25ob5 1037 10 the the DT cord-006856-b1w25ob5 1037 11 role role NN cord-006856-b1w25ob5 1037 12 of of IN cord-006856-b1w25ob5 1037 13 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1037 14 in in IN cord-006856-b1w25ob5 1037 15 the the DT cord-006856-b1w25ob5 1037 16 context context NN cord-006856-b1w25ob5 1037 17 of of IN cord-006856-b1w25ob5 1037 18 chronic chronic JJ cord-006856-b1w25ob5 1037 19 allograft allograft NN cord-006856-b1w25ob5 1037 20 vasculopathy vasculopathy NNP cord-006856-b1w25ob5 1037 21 , , , cord-006856-b1w25ob5 1037 22 which which WDT cord-006856-b1w25ob5 1037 23 is be VBZ cord-006856-b1w25ob5 1037 24 characterized characterize VBN cord-006856-b1w25ob5 1037 25 by by IN cord-006856-b1w25ob5 1037 26 vascular vascular JJ cord-006856-b1w25ob5 1037 27 lesions lesion NNS cord-006856-b1w25ob5 1037 28 in in IN cord-006856-b1w25ob5 1037 29 the the DT cord-006856-b1w25ob5 1037 30 graft graft NN cord-006856-b1w25ob5 1037 31 that that WDT cord-006856-b1w25ob5 1037 32 consist consist VBP cord-006856-b1w25ob5 1037 33 of of IN cord-006856-b1w25ob5 1037 34 concentric concentric JJ cord-006856-b1w25ob5 1037 35 myointimal myointimal JJ cord-006856-b1w25ob5 1037 36 proliferation proliferation NN cord-006856-b1w25ob5 1037 37 , , , cord-006856-b1w25ob5 1037 38 resulting result VBG cord-006856-b1w25ob5 1037 39 in in IN cord-006856-b1w25ob5 1037 40 deterioration deterioration NN cord-006856-b1w25ob5 1037 41 of of IN cord-006856-b1w25ob5 1037 42 allograft allograft NN cord-006856-b1w25ob5 1037 43 function function NN cord-006856-b1w25ob5 1037 44 and and CC cord-006856-b1w25ob5 1037 45 organ organ NN cord-006856-b1w25ob5 1037 46 loss loss NN cord-006856-b1w25ob5 1037 47 . . . cord-006856-b1w25ob5 1038 1 The the DT cord-006856-b1w25ob5 1038 2 purpose purpose NN cord-006856-b1w25ob5 1038 3 of of IN cord-006856-b1w25ob5 1038 4 this this DT cord-006856-b1w25ob5 1038 5 study study NN cord-006856-b1w25ob5 1038 6 was be VBD cord-006856-b1w25ob5 1038 7 to to TO cord-006856-b1w25ob5 1038 8 understand understand VB cord-006856-b1w25ob5 1038 9 the the DT cord-006856-b1w25ob5 1038 10 role role NN cord-006856-b1w25ob5 1038 11 of of IN cord-006856-b1w25ob5 1038 12 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1038 13 in in IN cord-006856-b1w25ob5 1038 14 abnormal abnormal JJ cord-006856-b1w25ob5 1038 15 VSMC vsmc NN cord-006856-b1w25ob5 1038 16 proliferation proliferation NN cord-006856-b1w25ob5 1038 17 associated associate VBN cord-006856-b1w25ob5 1038 18 with with IN cord-006856-b1w25ob5 1038 19 chronic chronic JJ cord-006856-b1w25ob5 1038 20 rejection rejection NN cord-006856-b1w25ob5 1038 21 and and CC cord-006856-b1w25ob5 1038 22 to to TO cord-006856-b1w25ob5 1038 23 investigate investigate VB cord-006856-b1w25ob5 1038 24 the the DT cord-006856-b1w25ob5 1038 25 potential potential JJ cord-006856-b1w25ob5 1038 26 therapeutic therapeutic JJ cord-006856-b1w25ob5 1038 27 role role NN cord-006856-b1w25ob5 1038 28 of of IN cord-006856-b1w25ob5 1038 29 a a DT cord-006856-b1w25ob5 1038 30 specific specific JJ cord-006856-b1w25ob5 1038 31 inhibitor inhibitor NN cord-006856-b1w25ob5 1038 32 of of IN cord-006856-b1w25ob5 1038 33 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1038 34 activation activation NN cord-006856-b1w25ob5 1038 35 in in IN cord-006856-b1w25ob5 1038 36 chronic chronic JJ cord-006856-b1w25ob5 1038 37 allograft allograft NN cord-006856-b1w25ob5 1038 38 vasculopathy vasculopathy NNP cord-006856-b1w25ob5 1038 39 . . . cord-006856-b1w25ob5 1039 1 Methods method NNS cord-006856-b1w25ob5 1039 2 . . . cord-006856-b1w25ob5 1040 1 In in IN cord-006856-b1w25ob5 1040 2 vivo vivo NN cord-006856-b1w25ob5 1040 3 , , , cord-006856-b1w25ob5 1040 4 a a DT cord-006856-b1w25ob5 1040 5 mouse mouse NN cord-006856-b1w25ob5 1040 6 model model NN cord-006856-b1w25ob5 1040 7 of of IN cord-006856-b1w25ob5 1040 8 heterotopic heterotopic NNP cord-006856-b1w25ob5 1040 9 aorta aorta NNP cord-006856-b1w25ob5 1040 10 transplantation transplantation NN cord-006856-b1w25ob5 1040 11 in in IN cord-006856-b1w25ob5 1040 12 an an DT cord-006856-b1w25ob5 1040 13 allogenic allogenic JJ cord-006856-b1w25ob5 1040 14 setting setting NN cord-006856-b1w25ob5 1040 15 has have VBZ cord-006856-b1w25ob5 1040 16 been be VBN cord-006856-b1w25ob5 1040 17 used use VBN cord-006856-b1w25ob5 1040 18 . . . cord-006856-b1w25ob5 1041 1 Aortas Aortas NNP cord-006856-b1w25ob5 1041 2 were be VBD cord-006856-b1w25ob5 1041 3 allografted allografte VBN cord-006856-b1w25ob5 1041 4 into into IN cord-006856-b1w25ob5 1041 5 recipient recipient NN cord-006856-b1w25ob5 1041 6 mice mouse NNS cord-006856-b1w25ob5 1041 7 by by IN cord-006856-b1w25ob5 1041 8 a a DT cord-006856-b1w25ob5 1041 9 carotid carotid JJ cord-006856-b1w25ob5 1041 10 artery artery NN cord-006856-b1w25ob5 1041 11 cuff cuff NN cord-006856-b1w25ob5 1041 12 technique technique NN cord-006856-b1w25ob5 1041 13 , , , cord-006856-b1w25ob5 1041 14 using use VBG cord-006856-b1w25ob5 1041 15 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1041 16 ( ( -LRB- cord-006856-b1w25ob5 1041 17 H-2 H-2 NNP cord-006856-b1w25ob5 1041 18 b b NN cord-006856-b1w25ob5 1041 19 ) ) -RRB- cord-006856-b1w25ob5 1041 20 mice mouse NNS cord-006856-b1w25ob5 1041 21 as as IN cord-006856-b1w25ob5 1041 22 donors donor NNS cord-006856-b1w25ob5 1041 23 and and CC cord-006856-b1w25ob5 1041 24 BALB BALB NNP cord-006856-b1w25ob5 1041 25 / / SYM cord-006856-b1w25ob5 1041 26 c c NN cord-006856-b1w25ob5 1041 27 ( ( -LRB- cord-006856-b1w25ob5 1041 28 H-2 H-2 NNP cord-006856-b1w25ob5 1041 29 b b NN cord-006856-b1w25ob5 1041 30 ) ) -RRB- cord-006856-b1w25ob5 1041 31 mice mouse NNS cord-006856-b1w25ob5 1041 32 as as IN cord-006856-b1w25ob5 1041 33 recipients recipient NNS cord-006856-b1w25ob5 1041 34 . . . cord-006856-b1w25ob5 1042 1 Four four CD cord-006856-b1w25ob5 1042 2 weeks week NNS cord-006856-b1w25ob5 1042 3 after after IN cord-006856-b1w25ob5 1042 4 transplantation transplantation NN cord-006856-b1w25ob5 1042 5 , , , cord-006856-b1w25ob5 1042 6 the the DT cord-006856-b1w25ob5 1042 7 aortic aortic JJ cord-006856-b1w25ob5 1042 8 segments segment NNS cord-006856-b1w25ob5 1042 9 were be VBD cord-006856-b1w25ob5 1042 10 harvested harvest VBN cord-006856-b1w25ob5 1042 11 and and CC cord-006856-b1w25ob5 1042 12 immunofluorescence immunofluorescence NN cord-006856-b1w25ob5 1042 13 was be VBD cord-006856-b1w25ob5 1042 14 performed perform VBN cord-006856-b1w25ob5 1042 15 using use VBG cord-006856-b1w25ob5 1042 16 anti anti JJ cord-006856-b1w25ob5 1042 17 - - JJ cord-006856-b1w25ob5 1042 18 VSMC VSMC NNP cord-006856-b1w25ob5 1042 19 - - HYPH cord-006856-b1w25ob5 1042 20 α α NN cord-006856-b1w25ob5 1042 21 - - HYPH cord-006856-b1w25ob5 1042 22 actin actin NN cord-006856-b1w25ob5 1042 23 and and CC cord-006856-b1w25ob5 1042 24 anti anti JJ cord-006856-b1w25ob5 1042 25 - - JJ cord-006856-b1w25ob5 1042 26 phospho phospho JJ cord-006856-b1w25ob5 1042 27 - - HYPH cord-006856-b1w25ob5 1042 28 p38 p38 JJ cord-006856-b1w25ob5 1042 29 antibodies antibody NNS cord-006856-b1w25ob5 1042 30 . . . cord-006856-b1w25ob5 1043 1 TNF TNF NNP cord-006856-b1w25ob5 1043 2 - - HYPH cord-006856-b1w25ob5 1043 3 α α NN cord-006856-b1w25ob5 1043 4 serum serum NN cord-006856-b1w25ob5 1043 5 levels level NNS cord-006856-b1w25ob5 1043 6 were be VBD cord-006856-b1w25ob5 1043 7 measured measure VBN cord-006856-b1w25ob5 1043 8 by by IN cord-006856-b1w25ob5 1043 9 ELISA ELISA NNP cord-006856-b1w25ob5 1043 10 . . . cord-006856-b1w25ob5 1044 1 In in IN cord-006856-b1w25ob5 1044 2 vitro vitro FW cord-006856-b1w25ob5 1044 3 , , , cord-006856-b1w25ob5 1044 4 VSMCs vsmc NNS cord-006856-b1w25ob5 1044 5 were be VBD cord-006856-b1w25ob5 1044 6 isolated isolate VBN cord-006856-b1w25ob5 1044 7 from from IN cord-006856-b1w25ob5 1044 8 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1044 9 aortas aorta NNS cord-006856-b1w25ob5 1044 10 . . . cord-006856-b1w25ob5 1045 1 Expression expression NN cord-006856-b1w25ob5 1045 2 levels level NNS cord-006856-b1w25ob5 1045 3 of of IN cord-006856-b1w25ob5 1045 4 total total JJ cord-006856-b1w25ob5 1045 5 and and CC cord-006856-b1w25ob5 1045 6 phosphorylated phosphorylated JJ cord-006856-b1w25ob5 1045 7 forms form NNS cord-006856-b1w25ob5 1045 8 of of IN cord-006856-b1w25ob5 1045 9 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1045 10 as as RB cord-006856-b1w25ob5 1045 11 well well RB cord-006856-b1w25ob5 1045 12 as as IN cord-006856-b1w25ob5 1045 13 key key JJ cord-006856-b1w25ob5 1045 14 cell cell NN cord-006856-b1w25ob5 1045 15 cycle cycle NN cord-006856-b1w25ob5 1045 16 regulators regulator NNS cord-006856-b1w25ob5 1045 17 were be VBD cord-006856-b1w25ob5 1045 18 detected detect VBN cord-006856-b1w25ob5 1045 19 by by IN cord-006856-b1w25ob5 1045 20 Western western JJ cord-006856-b1w25ob5 1045 21 blot blot NN cord-006856-b1w25ob5 1045 22 . . . cord-006856-b1w25ob5 1046 1 Immunocytochemistry Immunocytochemistry NNP cord-006856-b1w25ob5 1046 2 was be VBD cord-006856-b1w25ob5 1046 3 performed perform VBN cord-006856-b1w25ob5 1046 4 with with IN cord-006856-b1w25ob5 1046 5 primary primary JJ cord-006856-b1w25ob5 1046 6 antibodies antibody NNS cord-006856-b1w25ob5 1046 7 directed direct VBN cord-006856-b1w25ob5 1046 8 against against IN cord-006856-b1w25ob5 1046 9 phospho phospho NN cord-006856-b1w25ob5 1046 10 - - : cord-006856-b1w25ob5 1046 11 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1046 12 . . . cord-006856-b1w25ob5 1047 1 Proliferation proliferation NN cord-006856-b1w25ob5 1047 2 of of IN cord-006856-b1w25ob5 1047 3 VSMCs vsmc NNS cord-006856-b1w25ob5 1047 4 was be VBD cord-006856-b1w25ob5 1047 5 measured measure VBN cord-006856-b1w25ob5 1047 6 by by IN cord-006856-b1w25ob5 1047 7 [ [ -LRB- cord-006856-b1w25ob5 1047 8 3 3 CD cord-006856-b1w25ob5 1047 9 H]thymidine h]thymidine JJ cord-006856-b1w25ob5 1047 10 incorporation incorporation NN cord-006856-b1w25ob5 1047 11 in in IN cord-006856-b1w25ob5 1047 12 the the DT cord-006856-b1w25ob5 1047 13 presence presence NN cord-006856-b1w25ob5 1047 14 or or CC cord-006856-b1w25ob5 1047 15 absence absence NN cord-006856-b1w25ob5 1047 16 of of IN cord-006856-b1w25ob5 1047 17 SB SB NNP cord-006856-b1w25ob5 1047 18 203580 203580 CD cord-006856-b1w25ob5 1047 19 , , , cord-006856-b1w25ob5 1047 20 a a DT cord-006856-b1w25ob5 1047 21 specific specific JJ cord-006856-b1w25ob5 1047 22 inhibitor inhibitor NN cord-006856-b1w25ob5 1047 23 of of IN cord-006856-b1w25ob5 1047 24 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1047 25 activation activation NN cord-006856-b1w25ob5 1047 26 . . . cord-006856-b1w25ob5 1048 1 Cell cell NN cord-006856-b1w25ob5 1048 2 cycle cycle NN cord-006856-b1w25ob5 1048 3 progression progression NN cord-006856-b1w25ob5 1048 4 was be VBD cord-006856-b1w25ob5 1048 5 monitored monitor VBN cord-006856-b1w25ob5 1048 6 by by IN cord-006856-b1w25ob5 1048 7 DNA dna NN cord-006856-b1w25ob5 1048 8 content content NN cord-006856-b1w25ob5 1048 9 analysis analysis NN cord-006856-b1w25ob5 1048 10 ; ; : cord-006856-b1w25ob5 1048 11 apoptosis apoptosis NN cord-006856-b1w25ob5 1048 12 by by IN cord-006856-b1w25ob5 1048 13 the the DT cord-006856-b1w25ob5 1048 14 Annexin Annexin NNP cord-006856-b1w25ob5 1048 15 V V NNP cord-006856-b1w25ob5 1048 16 binding binding NN cord-006856-b1w25ob5 1048 17 assay assay NN cord-006856-b1w25ob5 1048 18 . . . cord-006856-b1w25ob5 1049 1 Cell cell NN cord-006856-b1w25ob5 1049 2 lysates lysate NNS cord-006856-b1w25ob5 1049 3 were be VBD cord-006856-b1w25ob5 1049 4 probed probe VBN cord-006856-b1w25ob5 1049 5 with with IN cord-006856-b1w25ob5 1049 6 antibodies antibody NNS cord-006856-b1w25ob5 1049 7 directed direct VBN cord-006856-b1w25ob5 1049 8 against against IN cord-006856-b1w25ob5 1049 9 cyclindependent cyclindependent NN cord-006856-b1w25ob5 1049 10 kinase kinase NNP cord-006856-b1w25ob5 1049 11 2 2 CD cord-006856-b1w25ob5 1049 12 ( ( -LRB- cord-006856-b1w25ob5 1049 13 cdk2 cdk2 NNP cord-006856-b1w25ob5 1049 14 ) ) -RRB- cord-006856-b1w25ob5 1049 15 and and CC cord-006856-b1w25ob5 1049 16 Yin Yin NNP cord-006856-b1w25ob5 1049 17 Yang Yang NNP cord-006856-b1w25ob5 1049 18 1 1 CD cord-006856-b1w25ob5 1049 19 ( ( -LRB- cord-006856-b1w25ob5 1049 20 YY1 YY1 NNP cord-006856-b1w25ob5 1049 21 ) ) -RRB- cord-006856-b1w25ob5 1049 22 . . . cord-006856-b1w25ob5 1050 1 Results result NNS cord-006856-b1w25ob5 1050 2 . . . cord-006856-b1w25ob5 1051 1 In in IN cord-006856-b1w25ob5 1051 2 vivo vivo NN cord-006856-b1w25ob5 1051 3 , , , cord-006856-b1w25ob5 1051 4 4 4 CD cord-006856-b1w25ob5 1051 5 weeks week NNS cord-006856-b1w25ob5 1051 6 after after IN cord-006856-b1w25ob5 1051 7 the the DT cord-006856-b1w25ob5 1051 8 transplant transplant NN cord-006856-b1w25ob5 1051 9 aortic aortic JJ cord-006856-b1w25ob5 1051 10 segments segment NNS cord-006856-b1w25ob5 1051 11 were be VBD cord-006856-b1w25ob5 1051 12 significantly significantly RB cord-006856-b1w25ob5 1051 13 narrowed narrow VBN cord-006856-b1w25ob5 1051 14 due due IN cord-006856-b1w25ob5 1051 15 to to IN cord-006856-b1w25ob5 1051 16 neointimal neointimal JJ cord-006856-b1w25ob5 1051 17 hyperplasia hyperplasia NN cord-006856-b1w25ob5 1051 18 . . . cord-006856-b1w25ob5 1052 1 The the DT cord-006856-b1w25ob5 1052 2 neointimal neointimal JJ cord-006856-b1w25ob5 1052 3 lesions lesion NNS cord-006856-b1w25ob5 1052 4 mainly mainly RB cord-006856-b1w25ob5 1052 5 consisted consist VBD cord-006856-b1w25ob5 1052 6 of of IN cord-006856-b1w25ob5 1052 7 VSMCs vsmc NNS cord-006856-b1w25ob5 1052 8 and and CC cord-006856-b1w25ob5 1052 9 showed show VBD cord-006856-b1w25ob5 1052 10 profound profound JJ cord-006856-b1w25ob5 1052 11 activation activation NN cord-006856-b1w25ob5 1052 12 of of IN cord-006856-b1w25ob5 1052 13 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1052 14 as as IN cord-006856-b1w25ob5 1052 15 demonstrated demonstrate VBN cord-006856-b1w25ob5 1052 16 by by IN cord-006856-b1w25ob5 1052 17 immunofluorescence immunofluorescence NN cord-006856-b1w25ob5 1052 18 . . . cord-006856-b1w25ob5 1053 1 Further further RB cord-006856-b1w25ob5 1053 2 , , , cord-006856-b1w25ob5 1053 3 serum serum NN cord-006856-b1w25ob5 1053 4 TNF TNF NNP cord-006856-b1w25ob5 1053 5 - - HYPH cord-006856-b1w25ob5 1053 6 α α NN cord-006856-b1w25ob5 1053 7 levels level NNS cord-006856-b1w25ob5 1053 8 were be VBD cord-006856-b1w25ob5 1053 9 significantly significantly RB cord-006856-b1w25ob5 1053 10 increased increase VBN cord-006856-b1w25ob5 1053 11 even even RB cord-006856-b1w25ob5 1053 12 4 4 CD cord-006856-b1w25ob5 1053 13 weeks week NNS cord-006856-b1w25ob5 1053 14 after after IN cord-006856-b1w25ob5 1053 15 allogeneic allogeneic JJ cord-006856-b1w25ob5 1053 16 aortic aortic JJ cord-006856-b1w25ob5 1053 17 transplantation transplantation NN cord-006856-b1w25ob5 1053 18 , , , cord-006856-b1w25ob5 1053 19 suggesting suggest VBG cord-006856-b1w25ob5 1053 20 an an DT cord-006856-b1w25ob5 1053 21 important important JJ cord-006856-b1w25ob5 1053 22 role role NN cord-006856-b1w25ob5 1053 23 of of IN cord-006856-b1w25ob5 1053 24 p38 p38 CD cord-006856-b1w25ob5 1053 25 activation activation NN cord-006856-b1w25ob5 1053 26 in in IN cord-006856-b1w25ob5 1053 27 this this DT cord-006856-b1w25ob5 1053 28 model model NN cord-006856-b1w25ob5 1053 29 . . . cord-006856-b1w25ob5 1054 1 In in IN cord-006856-b1w25ob5 1054 2 vitro vitro FW cord-006856-b1w25ob5 1054 3 , , , cord-006856-b1w25ob5 1054 4 stimulation stimulation NN cord-006856-b1w25ob5 1054 5 of of IN cord-006856-b1w25ob5 1054 6 VSMCs vsmc NNS cord-006856-b1w25ob5 1054 7 with with IN cord-006856-b1w25ob5 1054 8 10 10 CD cord-006856-b1w25ob5 1054 9 % % NN cord-006856-b1w25ob5 1054 10 FCS FCS NNP cord-006856-b1w25ob5 1054 11 resulted result VBD cord-006856-b1w25ob5 1054 12 in in IN cord-006856-b1w25ob5 1054 13 a a DT cord-006856-b1w25ob5 1054 14 rapid rapid JJ cord-006856-b1w25ob5 1054 15 increase increase NN cord-006856-b1w25ob5 1054 16 of of IN cord-006856-b1w25ob5 1054 17 phosphorylated phosphorylated JJ cord-006856-b1w25ob5 1054 18 forms form NNS cord-006856-b1w25ob5 1054 19 of of IN cord-006856-b1w25ob5 1054 20 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1054 21 ( ( -LRB- cord-006856-b1w25ob5 1054 22 8.0 8.0 CD cord-006856-b1w25ob5 1054 23 ± ± NN cord-006856-b1w25ob5 1054 24 0.7 0.7 CD cord-006856-b1w25ob5 1054 25 fold fold NN cord-006856-b1w25ob5 1054 26 increase increase NN cord-006856-b1w25ob5 1054 27 ) ) -RRB- cord-006856-b1w25ob5 1054 28 when when WRB cord-006856-b1w25ob5 1054 29 compared compare VBN cord-006856-b1w25ob5 1054 30 with with IN cord-006856-b1w25ob5 1054 31 the the DT cord-006856-b1w25ob5 1054 32 nonstimulated nonstimulated JJ cord-006856-b1w25ob5 1054 33 quiescent quiescent JJ cord-006856-b1w25ob5 1054 34 state state NN cord-006856-b1w25ob5 1054 35 . . . cord-006856-b1w25ob5 1055 1 Immunocytochemistry Immunocytochemistry NNP cord-006856-b1w25ob5 1055 2 showed show VBD cord-006856-b1w25ob5 1055 3 higher high JJR cord-006856-b1w25ob5 1055 4 levels level NNS cord-006856-b1w25ob5 1055 5 of of IN cord-006856-b1w25ob5 1055 6 phospho phospho NN cord-006856-b1w25ob5 1055 7 - - : cord-006856-b1w25ob5 1055 8 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1055 9 in in IN cord-006856-b1w25ob5 1055 10 the the DT cord-006856-b1w25ob5 1055 11 nuclei nucleus NNS cord-006856-b1w25ob5 1055 12 as as RB cord-006856-b1w25ob5 1055 13 well well RB cord-006856-b1w25ob5 1055 14 as as IN cord-006856-b1w25ob5 1055 15 in in IN cord-006856-b1w25ob5 1055 16 the the DT cord-006856-b1w25ob5 1055 17 cytosol cytosol NN cord-006856-b1w25ob5 1055 18 after after IN cord-006856-b1w25ob5 1055 19 stimulation stimulation NN cord-006856-b1w25ob5 1055 20 . . . cord-006856-b1w25ob5 1056 1 SB SB NNP cord-006856-b1w25ob5 1056 2 203580 203580 CD cord-006856-b1w25ob5 1056 3 in in IN cord-006856-b1w25ob5 1056 4 a a DT cord-006856-b1w25ob5 1056 5 dose dose NN cord-006856-b1w25ob5 1056 6 - - HYPH cord-006856-b1w25ob5 1056 7 dependent dependent JJ cord-006856-b1w25ob5 1056 8 manner manner NN cord-006856-b1w25ob5 1056 9 significantly significantly RB cord-006856-b1w25ob5 1056 10 inhibited inhibit VBD cord-006856-b1w25ob5 1056 11 VSMC VSMC NNP cord-006856-b1w25ob5 1056 12 proliferation proliferation NN cord-006856-b1w25ob5 1056 13 , , , cord-006856-b1w25ob5 1056 14 which which WDT cord-006856-b1w25ob5 1056 15 was be VBD cord-006856-b1w25ob5 1056 16 due due JJ cord-006856-b1w25ob5 1056 17 to to IN cord-006856-b1w25ob5 1056 18 inhibition inhibition NN cord-006856-b1w25ob5 1056 19 of of IN cord-006856-b1w25ob5 1056 20 cell cell NN cord-006856-b1w25ob5 1056 21 cycle cycle NN cord-006856-b1w25ob5 1056 22 progression progression NN cord-006856-b1w25ob5 1056 23 at at IN cord-006856-b1w25ob5 1056 24 the the DT cord-006856-b1w25ob5 1056 25 G g NN cord-006856-b1w25ob5 1056 26 0 0 CD cord-006856-b1w25ob5 1056 27 /G /g SYM cord-006856-b1w25ob5 1056 28 1 1 CD cord-006856-b1w25ob5 1056 29 phase phase NN cord-006856-b1w25ob5 1056 30 . . . cord-006856-b1w25ob5 1057 1 We -PRON- PRP cord-006856-b1w25ob5 1057 2 did do VBD cord-006856-b1w25ob5 1057 3 not not RB cord-006856-b1w25ob5 1057 4 observe observe VB cord-006856-b1w25ob5 1057 5 apoptosis apoptosis NN cord-006856-b1w25ob5 1057 6 in in IN cord-006856-b1w25ob5 1057 7 the the DT cord-006856-b1w25ob5 1057 8 SB SB NNP cord-006856-b1w25ob5 1057 9 203580-treated 203580-treated CD cord-006856-b1w25ob5 1057 10 VSMCs vsmc NNS cord-006856-b1w25ob5 1057 11 at at IN cord-006856-b1w25ob5 1057 12 20 20 CD cord-006856-b1w25ob5 1057 13 µM µm CD cord-006856-b1w25ob5 1057 14 , , , cord-006856-b1w25ob5 1057 15 the the DT cord-006856-b1w25ob5 1057 16 highest high JJS cord-006856-b1w25ob5 1057 17 dose dose NN cord-006856-b1w25ob5 1057 18 being be VBG cord-006856-b1w25ob5 1057 19 tested test VBN cord-006856-b1w25ob5 1057 20 . . . cord-006856-b1w25ob5 1058 1 Blockade blockade NN cord-006856-b1w25ob5 1058 2 of of IN cord-006856-b1w25ob5 1058 3 p38-MAPK p38-mapk JJ cord-006856-b1w25ob5 1058 4 activation activation NN cord-006856-b1w25ob5 1058 5 decreased decrease VBD cord-006856-b1w25ob5 1058 6 protein protein NN cord-006856-b1w25ob5 1058 7 levels level NNS cord-006856-b1w25ob5 1058 8 of of IN cord-006856-b1w25ob5 1058 9 cdk2 cdk2 NNP cord-006856-b1w25ob5 1058 10 and and CC cord-006856-b1w25ob5 1058 11 the the DT cord-006856-b1w25ob5 1058 12 transcription transcription NN cord-006856-b1w25ob5 1058 13 factor factor NN cord-006856-b1w25ob5 1058 14 YY1 YY1 NNP cord-006856-b1w25ob5 1058 15 , , , cord-006856-b1w25ob5 1058 16 which which WDT cord-006856-b1w25ob5 1058 17 plays play VBZ cord-006856-b1w25ob5 1058 18 an an DT cord-006856-b1w25ob5 1058 19 important important JJ cord-006856-b1w25ob5 1058 20 role role NN cord-006856-b1w25ob5 1058 21 in in IN cord-006856-b1w25ob5 1058 22 VSMC VSMC NNP cord-006856-b1w25ob5 1058 23 DNA DNA NNP cord-006856-b1w25ob5 1058 24 replication replication NN cord-006856-b1w25ob5 1058 25 and and CC cord-006856-b1w25ob5 1058 26 protein protein NN cord-006856-b1w25ob5 1058 27 synthesis synthesis NN cord-006856-b1w25ob5 1058 28 . . . cord-006856-b1w25ob5 1059 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1059 2 . . . cord-006856-b1w25ob5 1060 1 p38 p38 CD cord-006856-b1w25ob5 1060 2 MAPK MAPK NNP cord-006856-b1w25ob5 1060 3 activation activation NN cord-006856-b1w25ob5 1060 4 appears appear VBZ cord-006856-b1w25ob5 1060 5 to to TO cord-006856-b1w25ob5 1060 6 play play VB cord-006856-b1w25ob5 1060 7 an an DT cord-006856-b1w25ob5 1060 8 important important JJ cord-006856-b1w25ob5 1060 9 role role NN cord-006856-b1w25ob5 1060 10 in in IN cord-006856-b1w25ob5 1060 11 an an DT cord-006856-b1w25ob5 1060 12 in in IN cord-006856-b1w25ob5 1060 13 vivo vivo NN cord-006856-b1w25ob5 1060 14 allogeneic allogeneic NN cord-006856-b1w25ob5 1060 15 model model NN cord-006856-b1w25ob5 1060 16 of of IN cord-006856-b1w25ob5 1060 17 aorta aorta JJ cord-006856-b1w25ob5 1060 18 transplantation transplantation NN cord-006856-b1w25ob5 1060 19 as as RB cord-006856-b1w25ob5 1060 20 well well RB cord-006856-b1w25ob5 1060 21 as as IN cord-006856-b1w25ob5 1060 22 in in IN cord-006856-b1w25ob5 1060 23 VSMC VSMC NNP cord-006856-b1w25ob5 1060 24 proliferation proliferation NN cord-006856-b1w25ob5 1060 25 in in IN cord-006856-b1w25ob5 1060 26 vitro vitro FW cord-006856-b1w25ob5 1060 27 , , , cord-006856-b1w25ob5 1060 28 blocking block VBG cord-006856-b1w25ob5 1060 29 of of IN cord-006856-b1w25ob5 1060 30 which which WDT cord-006856-b1w25ob5 1060 31 prevents prevent VBZ cord-006856-b1w25ob5 1060 32 the the DT cord-006856-b1w25ob5 1060 33 cells cell NNS cord-006856-b1w25ob5 1060 34 from from IN cord-006856-b1w25ob5 1060 35 entering enter VBG cord-006856-b1w25ob5 1060 36 the the DT cord-006856-b1w25ob5 1060 37 S S NNP cord-006856-b1w25ob5 1060 38 phase phase NN cord-006856-b1w25ob5 1060 39 of of IN cord-006856-b1w25ob5 1060 40 the the DT cord-006856-b1w25ob5 1060 41 cell cell NN cord-006856-b1w25ob5 1060 42 cycle cycle NN cord-006856-b1w25ob5 1060 43 , , , cord-006856-b1w25ob5 1060 44 thus thus RB cord-006856-b1w25ob5 1060 45 abrogating abrogate VBG cord-006856-b1w25ob5 1060 46 cell cell NN cord-006856-b1w25ob5 1060 47 proliferation proliferation NN cord-006856-b1w25ob5 1060 48 . . . cord-006856-b1w25ob5 1061 1 Targeting target VBG cord-006856-b1w25ob5 1061 2 p38-MAPK p38-MAPK NNP cord-006856-b1w25ob5 1061 3 might may MD cord-006856-b1w25ob5 1061 4 become become VB cord-006856-b1w25ob5 1061 5 a a DT cord-006856-b1w25ob5 1061 6 potent potent JJ cord-006856-b1w25ob5 1061 7 strategy strategy NN cord-006856-b1w25ob5 1061 8 in in IN cord-006856-b1w25ob5 1061 9 the the DT cord-006856-b1w25ob5 1061 10 treatment treatment NN cord-006856-b1w25ob5 1061 11 of of IN cord-006856-b1w25ob5 1061 12 vascular vascular JJ cord-006856-b1w25ob5 1061 13 proliferative proliferative JJ cord-006856-b1w25ob5 1061 14 diseases disease NNS cord-006856-b1w25ob5 1061 15 like like IN cord-006856-b1w25ob5 1061 16 chronic chronic JJ cord-006856-b1w25ob5 1061 17 allograft allograft NN cord-006856-b1w25ob5 1061 18 vasculopathy vasculopathy NNP cord-006856-b1w25ob5 1061 19 . . . cord-006856-b1w25ob5 1062 1 Background background NN cord-006856-b1w25ob5 1062 2 . . . cord-006856-b1w25ob5 1063 1 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1063 2 , , , cord-006856-b1w25ob5 1063 3 a a DT cord-006856-b1w25ob5 1063 4 costimulation costimulation NN cord-006856-b1w25ob5 1063 5 blocker blocker NN cord-006856-b1w25ob5 1063 6 which which WDT cord-006856-b1w25ob5 1063 7 is be VBZ cord-006856-b1w25ob5 1063 8 currently currently RB cord-006856-b1w25ob5 1063 9 under under IN cord-006856-b1w25ob5 1063 10 advanced advanced JJ cord-006856-b1w25ob5 1063 11 clinical clinical JJ cord-006856-b1w25ob5 1063 12 development development NN cord-006856-b1w25ob5 1063 13 , , , cord-006856-b1w25ob5 1063 14 has have VBZ cord-006856-b1w25ob5 1063 15 been be VBN cord-006856-b1w25ob5 1063 16 used use VBN cord-006856-b1w25ob5 1063 17 for for IN cord-006856-b1w25ob5 1063 18 years year NNS cord-006856-b1w25ob5 1063 19 as as IN cord-006856-b1w25ob5 1063 20 part part NN cord-006856-b1w25ob5 1063 21 of of IN cord-006856-b1w25ob5 1063 22 mixed mixed JJ cord-006856-b1w25ob5 1063 23 chimerism chimerism NN cord-006856-b1w25ob5 1063 24 protocols protocol NNS cord-006856-b1w25ob5 1063 25 . . . cord-006856-b1w25ob5 1064 1 Recent recent JJ cord-006856-b1w25ob5 1064 2 data datum NNS cord-006856-b1w25ob5 1064 3 suggest suggest VBP cord-006856-b1w25ob5 1064 4 that that IN cord-006856-b1w25ob5 1064 5 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1064 6 also also RB cord-006856-b1w25ob5 1064 7 functions function VBZ cord-006856-b1w25ob5 1064 8 via via IN cord-006856-b1w25ob5 1064 9 modulation modulation NN cord-006856-b1w25ob5 1064 10 of of IN cord-006856-b1w25ob5 1064 11 tryptophan tryptophan NN cord-006856-b1w25ob5 1064 12 metabolism metabolism NN cord-006856-b1w25ob5 1064 13 by by IN cord-006856-b1w25ob5 1064 14 upregulating upregulate VBG cord-006856-b1w25ob5 1064 15 indoleamine indoleamine NNP cord-006856-b1w25ob5 1064 16 2,3-dioxygenase 2,3-dioxygenase NNP cord-006856-b1w25ob5 1064 17 ( ( -LRB- cord-006856-b1w25ob5 1064 18 IDO IDO NNP cord-006856-b1w25ob5 1064 19 ) ) -RRB- cord-006856-b1w25ob5 1064 20 through through IN cord-006856-b1w25ob5 1064 21 B7 b7 NN cord-006856-b1w25ob5 1064 22 signals signal NNS cord-006856-b1w25ob5 1064 23 . . . cord-006856-b1w25ob5 1065 1 We -PRON- PRP cord-006856-b1w25ob5 1065 2 thus thus RB cord-006856-b1w25ob5 1065 3 investigated investigate VBD cord-006856-b1w25ob5 1065 4 the the DT cord-006856-b1w25ob5 1065 5 role role NN cord-006856-b1w25ob5 1065 6 of of IN cord-006856-b1w25ob5 1065 7 IDO IDO NNP cord-006856-b1w25ob5 1065 8 in in IN cord-006856-b1w25ob5 1065 9 our -PRON- PRP$ cord-006856-b1w25ob5 1065 10 CTLA4Ig ctla4ig NN cord-006856-b1w25ob5 1065 11 - - HYPH cord-006856-b1w25ob5 1065 12 based base VBN cord-006856-b1w25ob5 1065 13 mixed mixed JJ cord-006856-b1w25ob5 1065 14 chimerism chimerism NN cord-006856-b1w25ob5 1065 15 protocol protocol NN cord-006856-b1w25ob5 1065 16 . . . cord-006856-b1w25ob5 1066 1 Methods method NNS cord-006856-b1w25ob5 1066 2 . . . cord-006856-b1w25ob5 1067 1 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1068 1 mice mouse NNS cord-006856-b1w25ob5 1068 2 received receive VBD cord-006856-b1w25ob5 1068 3 a a DT cord-006856-b1w25ob5 1068 4 total total JJ cord-006856-b1w25ob5 1068 5 body body NN cord-006856-b1w25ob5 1068 6 irradiation irradiation NN cord-006856-b1w25ob5 1068 7 ( ( -LRB- cord-006856-b1w25ob5 1068 8 TBI TBI NNP cord-006856-b1w25ob5 1068 9 , , , cord-006856-b1w25ob5 1068 10 d d NNP cord-006856-b1w25ob5 1068 11 -1 -1 NNP cord-006856-b1w25ob5 1068 12 ) ) -RRB- cord-006856-b1w25ob5 1068 13 of of IN cord-006856-b1w25ob5 1068 14 3 3 CD cord-006856-b1w25ob5 1068 15 Gy Gy NNP cord-006856-b1w25ob5 1068 16 , , , cord-006856-b1w25ob5 1068 17 approx approx NN cord-006856-b1w25ob5 1068 18 . . . cord-006856-b1w25ob5 1069 1 20 20 CD cord-006856-b1w25ob5 1069 2 × × NN cord-006856-b1w25ob5 1069 3 10 10 CD cord-006856-b1w25ob5 1069 4 6 6 CD cord-006856-b1w25ob5 1070 1 fully fully RB cord-006856-b1w25ob5 1070 2 allogeneic allogeneic IN cord-006856-b1w25ob5 1070 3 BALB BALB NNP cord-006856-b1w25ob5 1070 4 / / SYM cord-006856-b1w25ob5 1070 5 c c NN cord-006856-b1w25ob5 1070 6 bone bone NN cord-006856-b1w25ob5 1070 7 marrow marrow NN cord-006856-b1w25ob5 1070 8 cells cell NNS cord-006856-b1w25ob5 1070 9 ( ( -LRB- cord-006856-b1w25ob5 1070 10 d d NN cord-006856-b1w25ob5 1070 11 0 0 CD cord-006856-b1w25ob5 1070 12 ) ) -RRB- cord-006856-b1w25ob5 1070 13 and and CC cord-006856-b1w25ob5 1070 14 costimulation costimulation NN cord-006856-b1w25ob5 1070 15 blockade blockade NN cord-006856-b1w25ob5 1070 16 consisting consist VBG cord-006856-b1w25ob5 1070 17 of of IN cord-006856-b1w25ob5 1070 18 anti anti JJ cord-006856-b1w25ob5 1070 19 - - JJ cord-006856-b1w25ob5 1070 20 CD154 cd154 CD cord-006856-b1w25ob5 1070 21 mAb mAb NNS cord-006856-b1w25ob5 1070 22 ( ( -LRB- cord-006856-b1w25ob5 1070 23 1 1 CD cord-006856-b1w25ob5 1070 24 mg mg NNP cord-006856-b1w25ob5 1070 25 , , , cord-006856-b1w25ob5 1070 26 d d NNP cord-006856-b1w25ob5 1070 27 0 0 CD cord-006856-b1w25ob5 1070 28 ) ) -RRB- cord-006856-b1w25ob5 1070 29 and and CC cord-006856-b1w25ob5 1071 1 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1071 2 ( ( -LRB- cord-006856-b1w25ob5 1071 3 0.5 0.5 CD cord-006856-b1w25ob5 1071 4 mg mg NNP cord-006856-b1w25ob5 1071 5 , , , cord-006856-b1w25ob5 1071 6 d d NNP cord-006856-b1w25ob5 1071 7 2 2 CD cord-006856-b1w25ob5 1071 8 ) ) -RRB- cord-006856-b1w25ob5 1071 9 . . . cord-006856-b1w25ob5 1072 1 Different different JJ cord-006856-b1w25ob5 1072 2 groups group NNS cord-006856-b1w25ob5 1072 3 of of IN cord-006856-b1w25ob5 1072 4 mice mouse NNS cord-006856-b1w25ob5 1072 5 were be VBD cord-006856-b1w25ob5 1072 6 additionally additionally RB cord-006856-b1w25ob5 1072 7 implanted implant VBN cord-006856-b1w25ob5 1072 8 with with IN cord-006856-b1w25ob5 1072 9 1-methyltryptophan 1-methyltryptophan CD cord-006856-b1w25ob5 1072 10 pellets pellet NNS cord-006856-b1w25ob5 1072 11 on on IN cord-006856-b1w25ob5 1072 12 d d NN cord-006856-b1w25ob5 1072 13 -1 -1 NN cord-006856-b1w25ob5 1073 1 ( ( -LRB- cord-006856-b1w25ob5 1073 2 1-MT 1-mt CD cord-006856-b1w25ob5 1073 3 , , , cord-006856-b1w25ob5 1073 4 which which WDT cord-006856-b1w25ob5 1073 5 is be VBZ cord-006856-b1w25ob5 1073 6 a a DT cord-006856-b1w25ob5 1073 7 competitive competitive JJ cord-006856-b1w25ob5 1073 8 inhibitor inhibitor NN cord-006856-b1w25ob5 1073 9 of of IN cord-006856-b1w25ob5 1073 10 IDO IDO NNP cord-006856-b1w25ob5 1073 11 , , , cord-006856-b1w25ob5 1073 12 7-day 7-day JJ cord-006856-b1w25ob5 1073 13 release release NN cord-006856-b1w25ob5 1073 14 at at IN cord-006856-b1w25ob5 1073 15 0.9 0.9 CD cord-006856-b1w25ob5 1073 16 mg mg NNP cord-006856-b1w25ob5 1073 17 / / SYM cord-006856-b1w25ob5 1073 18 h h NNP cord-006856-b1w25ob5 1073 19 ) ) -RRB- cord-006856-b1w25ob5 1073 20 or or CC cord-006856-b1w25ob5 1073 21 on on IN cord-006856-b1w25ob5 1073 22 d d NNP cord-006856-b1w25ob5 1073 23 -1 -1 NN cord-006856-b1w25ob5 1073 24 and and CC cord-006856-b1w25ob5 1073 25 d d NNP cord-006856-b1w25ob5 1073 26 6 6 CD cord-006856-b1w25ob5 1073 27 ( ( -LRB- cord-006856-b1w25ob5 1073 28 14-day 14-day CD cord-006856-b1w25ob5 1073 29 release release NN cord-006856-b1w25ob5 1073 30 ) ) -RRB- cord-006856-b1w25ob5 1073 31 or or CC cord-006856-b1w25ob5 1073 32 placebo placebo NN cord-006856-b1w25ob5 1073 33 pellets pellet NNS cord-006856-b1w25ob5 1073 34 . . . cord-006856-b1w25ob5 1074 1 Macrochimerism macrochimerism NN cord-006856-b1w25ob5 1074 2 and and CC cord-006856-b1w25ob5 1074 3 deletion deletion NN cord-006856-b1w25ob5 1074 4 of of IN cord-006856-b1w25ob5 1074 5 donor donor NN cord-006856-b1w25ob5 1074 6 - - HYPH cord-006856-b1w25ob5 1074 7 reactive reactive JJ cord-006856-b1w25ob5 1074 8 cells cell NNS cord-006856-b1w25ob5 1074 9 were be VBD cord-006856-b1w25ob5 1074 10 followed follow VBN cord-006856-b1w25ob5 1074 11 by by IN cord-006856-b1w25ob5 1074 12 flow flow NN cord-006856-b1w25ob5 1074 13 cytometry cytometry NN cord-006856-b1w25ob5 1074 14 . . . cord-006856-b1w25ob5 1075 1 Levels level NNS cord-006856-b1w25ob5 1075 2 of of IN cord-006856-b1w25ob5 1075 3 tryptophan tryptophan NN cord-006856-b1w25ob5 1075 4 , , , cord-006856-b1w25ob5 1075 5 kynurenine kynurenine NN cord-006856-b1w25ob5 1075 6 , , , cord-006856-b1w25ob5 1075 7 and and CC cord-006856-b1w25ob5 1075 8 1-MT 1-mt CD cord-006856-b1w25ob5 1075 9 were be VBD cord-006856-b1w25ob5 1075 10 measured measure VBN cord-006856-b1w25ob5 1075 11 at at IN cord-006856-b1w25ob5 1075 12 several several JJ cord-006856-b1w25ob5 1075 13 timepoints timepoint NNS cord-006856-b1w25ob5 1075 14 in in IN cord-006856-b1w25ob5 1075 15 serum serum NN cord-006856-b1w25ob5 1075 16 by by IN cord-006856-b1w25ob5 1075 17 HPLC HPLC NNP cord-006856-b1w25ob5 1075 18 . . . cord-006856-b1w25ob5 1076 1 Results result NNS cord-006856-b1w25ob5 1076 2 . . . cord-006856-b1w25ob5 1077 1 8 8 CD cord-006856-b1w25ob5 1077 2 of of IN cord-006856-b1w25ob5 1077 3 10 10 CD cord-006856-b1w25ob5 1077 4 mice mouse NNS cord-006856-b1w25ob5 1077 5 which which WDT cord-006856-b1w25ob5 1077 6 received receive VBD cord-006856-b1w25ob5 1077 7 BMT BMT NNP cord-006856-b1w25ob5 1077 8 , , , cord-006856-b1w25ob5 1077 9 TBI TBI NNP cord-006856-b1w25ob5 1077 10 , , , cord-006856-b1w25ob5 1077 11 MR1 MR1 NNP cord-006856-b1w25ob5 1077 12 plus plus CC cord-006856-b1w25ob5 1077 13 CTLA4Ig ctla4ig NN cord-006856-b1w25ob5 1077 14 but but CC cord-006856-b1w25ob5 1077 15 only only RB cord-006856-b1w25ob5 1077 16 2 2 CD cord-006856-b1w25ob5 1077 17 of of IN cord-006856-b1w25ob5 1077 18 10 10 CD cord-006856-b1w25ob5 1077 19 mice mouse NNS cord-006856-b1w25ob5 1077 20 without without IN cord-006856-b1w25ob5 1077 21 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1077 22 developed develop VBD cord-006856-b1w25ob5 1077 23 lasting last VBG cord-006856-b1w25ob5 1077 24 multilineage multilineage NN cord-006856-b1w25ob5 1077 25 chimerism chimerism NN cord-006856-b1w25ob5 1077 26 ( ( -LRB- cord-006856-b1w25ob5 1077 27 P p NN cord-006856-b1w25ob5 1077 28 < < XX cord-006856-b1w25ob5 1077 29 0.05 0.05 CD cord-006856-b1w25ob5 1077 30 , , , cord-006856-b1w25ob5 1077 31 measured measure VBN cord-006856-b1w25ob5 1077 32 at at IN cord-006856-b1w25ob5 1077 33 week week NN cord-006856-b1w25ob5 1077 34 32 32 CD cord-006856-b1w25ob5 1077 35 post post NN cord-006856-b1w25ob5 1077 36 BMT BMT NNP cord-006856-b1w25ob5 1077 37 ) ) -RRB- cord-006856-b1w25ob5 1077 38 . . . cord-006856-b1w25ob5 1078 1 8 8 CD cord-006856-b1w25ob5 1078 2 of of IN cord-006856-b1w25ob5 1078 3 10 10 CD cord-006856-b1w25ob5 1078 4 mice mouse NNS cord-006856-b1w25ob5 1078 5 with with IN cord-006856-b1w25ob5 1078 6 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1078 7 treatment treatment NN cord-006856-b1w25ob5 1078 8 accepted accept VBN cord-006856-b1w25ob5 1078 9 donor donor NN cord-006856-b1w25ob5 1078 10 skin skin NN cord-006856-b1w25ob5 1078 11 grafts graft NNS cord-006856-b1w25ob5 1078 12 for for IN cord-006856-b1w25ob5 1078 13 more more JJR cord-006856-b1w25ob5 1078 14 than than IN cord-006856-b1w25ob5 1078 15 150 150 CD cord-006856-b1w25ob5 1078 16 days day NNS cord-006856-b1w25ob5 1078 17 , , , cord-006856-b1w25ob5 1078 18 whereas whereas IN cord-006856-b1w25ob5 1078 19 only only RB cord-006856-b1w25ob5 1078 20 1 1 CD cord-006856-b1w25ob5 1078 21 of of IN cord-006856-b1w25ob5 1078 22 10 10 CD cord-006856-b1w25ob5 1078 23 mice mouse NNS cord-006856-b1w25ob5 1078 24 , , , cord-006856-b1w25ob5 1078 25 which which WDT cord-006856-b1w25ob5 1078 26 got get VBD cord-006856-b1w25ob5 1078 27 no no DT cord-006856-b1w25ob5 1078 28 CTLA4Ig ctla4ig NN cord-006856-b1w25ob5 1078 29 injection injection NN cord-006856-b1w25ob5 1078 30 accepted accept VBN cord-006856-b1w25ob5 1078 31 donor donor NN cord-006856-b1w25ob5 1078 32 skin skin NN cord-006856-b1w25ob5 1078 33 long long JJ cord-006856-b1w25ob5 1078 34 - - HYPH cord-006856-b1w25ob5 1078 35 term term NN cord-006856-b1w25ob5 1078 36 ( ( -LRB- cord-006856-b1w25ob5 1078 37 P p NN cord-006856-b1w25ob5 1078 38 < < XX cord-006856-b1w25ob5 1078 39 0.05 0.05 CD cord-006856-b1w25ob5 1078 40 ; ; : cord-006856-b1w25ob5 1078 41 representative representative JJ cord-006856-b1w25ob5 1078 42 data datum NNS cord-006856-b1w25ob5 1078 43 from from IN cord-006856-b1w25ob5 1078 44 two two CD cord-006856-b1w25ob5 1078 45 separate separate JJ cord-006856-b1w25ob5 1078 46 experiments experiment NNS cord-006856-b1w25ob5 1078 47 ) ) -RRB- cord-006856-b1w25ob5 1078 48 , , , cord-006856-b1w25ob5 1078 49 demonstrating demonstrate VBG cord-006856-b1w25ob5 1078 50 that that IN cord-006856-b1w25ob5 1078 51 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1078 52 is be VBZ cord-006856-b1w25ob5 1078 53 critical critical JJ cord-006856-b1w25ob5 1078 54 for for IN cord-006856-b1w25ob5 1078 55 our -PRON- PRP$ cord-006856-b1w25ob5 1078 56 protocol protocol NN cord-006856-b1w25ob5 1078 57 . . . cord-006856-b1w25ob5 1079 1 3rd 3rd JJ cord-006856-b1w25ob5 1079 2 - - HYPH cord-006856-b1w25ob5 1079 3 party party NN cord-006856-b1w25ob5 1079 4 grafts graft NNS cord-006856-b1w25ob5 1079 5 were be VBD cord-006856-b1w25ob5 1079 6 promptly promptly RB cord-006856-b1w25ob5 1079 7 rejected reject VBN cord-006856-b1w25ob5 1079 8 in in IN cord-006856-b1w25ob5 1079 9 all all DT cord-006856-b1w25ob5 1079 10 groups group NNS cord-006856-b1w25ob5 1079 11 . . . cord-006856-b1w25ob5 1080 1 Long long JJ cord-006856-b1w25ob5 1080 2 - - HYPH cord-006856-b1w25ob5 1080 3 term term NN cord-006856-b1w25ob5 1080 4 multilineage multilineage NN cord-006856-b1w25ob5 1080 5 chimerism chimerism NN cord-006856-b1w25ob5 1080 6 developed develop VBN cord-006856-b1w25ob5 1080 7 in in IN cord-006856-b1w25ob5 1080 8 6 6 CD cord-006856-b1w25ob5 1080 9 of of IN cord-006856-b1w25ob5 1080 10 8 8 CD cord-006856-b1w25ob5 1080 11 mice mouse NNS cord-006856-b1w25ob5 1080 12 with with IN cord-006856-b1w25ob5 1080 13 1-MT 1-mt CD cord-006856-b1w25ob5 1080 14 treatment treatment NN cord-006856-b1w25ob5 1080 15 , , , cord-006856-b1w25ob5 1080 16 which which WDT cord-006856-b1w25ob5 1080 17 is be VBZ cord-006856-b1w25ob5 1080 18 not not RB cord-006856-b1w25ob5 1080 19 significantly significantly RB cord-006856-b1w25ob5 1080 20 different different JJ cord-006856-b1w25ob5 1080 21 from from IN cord-006856-b1w25ob5 1080 22 treatment treatment NN cord-006856-b1w25ob5 1080 23 with with IN cord-006856-b1w25ob5 1080 24 placebo placebo NN cord-006856-b1w25ob5 1080 25 pellets pellet NNS cord-006856-b1w25ob5 1080 26 or or CC cord-006856-b1w25ob5 1080 27 standard standard JJ cord-006856-b1w25ob5 1080 28 protocol protocol NN cord-006856-b1w25ob5 1080 29 alone alone RB cord-006856-b1w25ob5 1080 30 ( ( -LRB- cord-006856-b1w25ob5 1080 31 7 7 CD cord-006856-b1w25ob5 1080 32 of of IN cord-006856-b1w25ob5 1080 33 11 11 CD cord-006856-b1w25ob5 1080 34 , , , cord-006856-b1w25ob5 1080 35 pooled pool VBN cord-006856-b1w25ob5 1080 36 data datum NNS cord-006856-b1w25ob5 1080 37 from from IN cord-006856-b1w25ob5 1080 38 both both DT cord-006856-b1w25ob5 1080 39 groups group NNS cord-006856-b1w25ob5 1080 40 ) ) -RRB- cord-006856-b1w25ob5 1080 41 . . . cord-006856-b1w25ob5 1081 1 2-week 2-week CD cord-006856-b1w25ob5 1081 2 treatment treatment NN cord-006856-b1w25ob5 1081 3 with with IN cord-006856-b1w25ob5 1081 4 1-MT 1-mt CD cord-006856-b1w25ob5 1081 5 also also RB cord-006856-b1w25ob5 1081 6 did do VBD cord-006856-b1w25ob5 1081 7 not not RB cord-006856-b1w25ob5 1081 8 lead lead VB cord-006856-b1w25ob5 1081 9 to to IN cord-006856-b1w25ob5 1081 10 a a DT cord-006856-b1w25ob5 1081 11 significant significant JJ cord-006856-b1w25ob5 1081 12 difference difference NN cord-006856-b1w25ob5 1081 13 in in IN cord-006856-b1w25ob5 1081 14 the the DT cord-006856-b1w25ob5 1081 15 rate rate NN cord-006856-b1w25ob5 1081 16 of of IN cord-006856-b1w25ob5 1081 17 multilineage multilineage NN cord-006856-b1w25ob5 1081 18 chimerism chimerism NN cord-006856-b1w25ob5 1081 19 ( ( -LRB- cord-006856-b1w25ob5 1081 20 4 4 CD cord-006856-b1w25ob5 1081 21 of of IN cord-006856-b1w25ob5 1081 22 5 5 CD cord-006856-b1w25ob5 1081 23 with with IN cord-006856-b1w25ob5 1081 24 1-MT 1-mt CD cord-006856-b1w25ob5 1081 25 vs. vs. NN cord-006856-b1w25ob5 1081 26 4 4 CD cord-006856-b1w25ob5 1081 27 of of IN cord-006856-b1w25ob5 1081 28 7 7 CD cord-006856-b1w25ob5 1081 29 without without IN cord-006856-b1w25ob5 1081 30 1-MT 1-mt CD cord-006856-b1w25ob5 1081 31 ) ) -RRB- cord-006856-b1w25ob5 1081 32 . . . cord-006856-b1w25ob5 1082 1 Deletion deletion NN cord-006856-b1w25ob5 1082 2 of of IN cord-006856-b1w25ob5 1082 3 donor donor NN cord-006856-b1w25ob5 1082 4 - - HYPH cord-006856-b1w25ob5 1082 5 reactive reactive JJ cord-006856-b1w25ob5 1082 6 T t NN cord-006856-b1w25ob5 1082 7 cells cell NNS cord-006856-b1w25ob5 1082 8 was be VBD cord-006856-b1w25ob5 1082 9 neither neither CC cord-006856-b1w25ob5 1082 10 blocked block VBN cord-006856-b1w25ob5 1082 11 nor nor CC cord-006856-b1w25ob5 1082 12 enhanced enhance VBN cord-006856-b1w25ob5 1082 13 by by IN cord-006856-b1w25ob5 1082 14 treatment treatment NN cord-006856-b1w25ob5 1082 15 with with IN cord-006856-b1w25ob5 1082 16 1-MT 1-mt CD cord-006856-b1w25ob5 1082 17 . . . cord-006856-b1w25ob5 1083 1 The the DT cord-006856-b1w25ob5 1083 2 kynurenine kynurenine NN cord-006856-b1w25ob5 1083 3 - - HYPH cord-006856-b1w25ob5 1083 4 to to IN cord-006856-b1w25ob5 1083 5 - - HYPH cord-006856-b1w25ob5 1083 6 tryptophan tryptophan NN cord-006856-b1w25ob5 1083 7 ratio ratio NN cord-006856-b1w25ob5 1083 8 in in IN cord-006856-b1w25ob5 1083 9 serum serum NN cord-006856-b1w25ob5 1083 10 was be VBD cord-006856-b1w25ob5 1083 11 similar similar JJ cord-006856-b1w25ob5 1083 12 in in IN cord-006856-b1w25ob5 1083 13 groups group NNS cord-006856-b1w25ob5 1083 14 with with IN cord-006856-b1w25ob5 1083 15 ( ( -LRB- cord-006856-b1w25ob5 1083 16 11.8 11.8 CD cord-006856-b1w25ob5 1083 17 ± ± CD cord-006856-b1w25ob5 1083 18 2.7 2.7 CD cord-006856-b1w25ob5 1083 19 ) ) -RRB- cord-006856-b1w25ob5 1083 20 and and CC cord-006856-b1w25ob5 1083 21 without without IN cord-006856-b1w25ob5 1083 22 ( ( -LRB- cord-006856-b1w25ob5 1083 23 12.1 12.1 CD cord-006856-b1w25ob5 1083 24 ± ± CD cord-006856-b1w25ob5 1083 25 3.3 3.3 CD cord-006856-b1w25ob5 1083 26 ) ) -RRB- cord-006856-b1w25ob5 1083 27 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1083 28 ( ( -LRB- cord-006856-b1w25ob5 1083 29 P p NN cord-006856-b1w25ob5 1083 30 = = SYM cord-006856-b1w25ob5 1083 31 n.s n.s NNP cord-006856-b1w25ob5 1083 32 . . NNP cord-006856-b1w25ob5 1083 33 , , , cord-006856-b1w25ob5 1083 34 measured measure VBN cord-006856-b1w25ob5 1083 35 on on IN cord-006856-b1w25ob5 1083 36 d d NNP cord-006856-b1w25ob5 1083 37 3 3 CD cord-006856-b1w25ob5 1083 38 ) ) -RRB- cord-006856-b1w25ob5 1083 39 . . . cord-006856-b1w25ob5 1084 1 Substantial substantial JJ cord-006856-b1w25ob5 1084 2 serum serum NN cord-006856-b1w25ob5 1084 3 levels level NNS cord-006856-b1w25ob5 1084 4 of of IN cord-006856-b1w25ob5 1084 5 1-MT 1-mt CD cord-006856-b1w25ob5 1084 6 were be VBD cord-006856-b1w25ob5 1084 7 detected detect VBN cord-006856-b1w25ob5 1084 8 in in IN cord-006856-b1w25ob5 1084 9 mice mouse NNS cord-006856-b1w25ob5 1084 10 with with IN cord-006856-b1w25ob5 1084 11 1-MT 1-mt CD cord-006856-b1w25ob5 1084 12 treatment treatment NN cord-006856-b1w25ob5 1084 13 but but CC cord-006856-b1w25ob5 1084 14 not not RB cord-006856-b1w25ob5 1084 15 in in IN cord-006856-b1w25ob5 1084 16 untreated untreated JJ cord-006856-b1w25ob5 1084 17 mice mouse NNS cord-006856-b1w25ob5 1084 18 , , , cord-006856-b1w25ob5 1084 19 indicating indicate VBG cord-006856-b1w25ob5 1084 20 that that IN cord-006856-b1w25ob5 1084 21 IDO IDO NNP cord-006856-b1w25ob5 1084 22 was be VBD cord-006856-b1w25ob5 1084 23 indeed indeed RB cord-006856-b1w25ob5 1084 24 inhibited inhibit VBN cord-006856-b1w25ob5 1084 25 in in IN cord-006856-b1w25ob5 1084 26 the the DT cord-006856-b1w25ob5 1084 27 1-MT 1-mt CD cord-006856-b1w25ob5 1084 28 groups group NNS cord-006856-b1w25ob5 1084 29 . . . cord-006856-b1w25ob5 1085 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1085 2 . . . cord-006856-b1w25ob5 1086 1 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1086 2 plays play VBZ cord-006856-b1w25ob5 1086 3 an an DT cord-006856-b1w25ob5 1086 4 essential essential JJ cord-006856-b1w25ob5 1086 5 role role NN cord-006856-b1w25ob5 1086 6 for for IN cord-006856-b1w25ob5 1086 7 tolerance tolerance NN cord-006856-b1w25ob5 1086 8 induction induction NN cord-006856-b1w25ob5 1086 9 in in IN cord-006856-b1w25ob5 1086 10 this this DT cord-006856-b1w25ob5 1086 11 model model NN cord-006856-b1w25ob5 1086 12 but but CC cord-006856-b1w25ob5 1086 13 its -PRON- PRP$ cord-006856-b1w25ob5 1086 14 mechanisms mechanism NNS cord-006856-b1w25ob5 1086 15 of of IN cord-006856-b1w25ob5 1086 16 action action NN cord-006856-b1w25ob5 1086 17 does do VBZ cord-006856-b1w25ob5 1086 18 not not RB cord-006856-b1w25ob5 1086 19 critically critically RB cord-006856-b1w25ob5 1086 20 depend depend VB cord-006856-b1w25ob5 1086 21 on on IN cord-006856-b1w25ob5 1086 22 IDO IDO NNP cord-006856-b1w25ob5 1086 23 . . . cord-006856-b1w25ob5 1087 1 Background background NN cord-006856-b1w25ob5 1087 2 . . . cord-006856-b1w25ob5 1088 1 Induction induction NN cord-006856-b1w25ob5 1088 2 of of IN cord-006856-b1w25ob5 1088 3 antigen antigen NN cord-006856-b1w25ob5 1088 4 - - HYPH cord-006856-b1w25ob5 1088 5 specific specific JJ cord-006856-b1w25ob5 1088 6 tolerance tolerance NN cord-006856-b1w25ob5 1088 7 remains remain VBZ cord-006856-b1w25ob5 1088 8 the the DT cord-006856-b1w25ob5 1088 9 ultimate ultimate JJ cord-006856-b1w25ob5 1088 10 goal goal NN cord-006856-b1w25ob5 1088 11 in in IN cord-006856-b1w25ob5 1088 12 clinical clinical JJ cord-006856-b1w25ob5 1088 13 organ organ NN cord-006856-b1w25ob5 1088 14 and and CC cord-006856-b1w25ob5 1088 15 cell cell NN cord-006856-b1w25ob5 1088 16 transplantation transplantation NN cord-006856-b1w25ob5 1088 17 , , , cord-006856-b1w25ob5 1088 18 as as IN cord-006856-b1w25ob5 1088 19 it -PRON- PRP cord-006856-b1w25ob5 1088 20 would would MD cord-006856-b1w25ob5 1088 21 eliminate eliminate VB cord-006856-b1w25ob5 1088 22 the the DT cord-006856-b1w25ob5 1088 23 need need NN cord-006856-b1w25ob5 1088 24 for for IN cord-006856-b1w25ob5 1088 25 continuous continuous JJ cord-006856-b1w25ob5 1088 26 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1088 27 . . . cord-006856-b1w25ob5 1089 1 One one CD cord-006856-b1w25ob5 1089 2 strategy strategy NN cord-006856-b1w25ob5 1089 3 leading lead VBG cord-006856-b1w25ob5 1089 4 to to IN cord-006856-b1w25ob5 1089 5 tolerance tolerance NN cord-006856-b1w25ob5 1089 6 induction induction NN cord-006856-b1w25ob5 1089 7 against against IN cord-006856-b1w25ob5 1089 8 a a DT cord-006856-b1w25ob5 1089 9 transplanted transplant VBN cord-006856-b1w25ob5 1089 10 organ organ NN cord-006856-b1w25ob5 1089 11 consists consist VBZ cord-006856-b1w25ob5 1089 12 of of IN cord-006856-b1w25ob5 1089 13 infusing infuse VBG cord-006856-b1w25ob5 1089 14 blood blood NN cord-006856-b1w25ob5 1089 15 from from IN cord-006856-b1w25ob5 1089 16 the the DT cord-006856-b1w25ob5 1089 17 organ organ NN cord-006856-b1w25ob5 1089 18 donor donor NN cord-006856-b1w25ob5 1089 19 , , , cord-006856-b1w25ob5 1089 20 an an DT cord-006856-b1w25ob5 1089 21 approach approach NN cord-006856-b1w25ob5 1089 22 known know VBN cord-006856-b1w25ob5 1089 23 as as IN cord-006856-b1w25ob5 1089 24 donor donor NN cord-006856-b1w25ob5 1089 25 - - HYPH cord-006856-b1w25ob5 1089 26 specific specific JJ cord-006856-b1w25ob5 1089 27 transfusion transfusion NN cord-006856-b1w25ob5 1089 28 ( ( -LRB- cord-006856-b1w25ob5 1089 29 DST DST NNP cord-006856-b1w25ob5 1089 30 ) ) -RRB- cord-006856-b1w25ob5 1089 31 . . . cord-006856-b1w25ob5 1090 1 Although although IN cord-006856-b1w25ob5 1090 2 the the DT cord-006856-b1w25ob5 1090 3 mechanisms mechanism NNS cord-006856-b1w25ob5 1090 4 underlying underlie VBG cord-006856-b1w25ob5 1090 5 tolerance tolerance NN cord-006856-b1w25ob5 1090 6 induction induction NN cord-006856-b1w25ob5 1090 7 by by IN cord-006856-b1w25ob5 1090 8 DST DST NNP cord-006856-b1w25ob5 1090 9 are be VBP cord-006856-b1w25ob5 1090 10 not not RB cord-006856-b1w25ob5 1090 11 fully fully RB cord-006856-b1w25ob5 1090 12 understood understand VBN cord-006856-b1w25ob5 1090 13 , , , cord-006856-b1w25ob5 1090 14 clonal clonal JJ cord-006856-b1w25ob5 1090 15 deletion deletion NN cord-006856-b1w25ob5 1090 16 of of IN cord-006856-b1w25ob5 1090 17 alloreactive alloreactive NNP cord-006856-b1w25ob5 1090 18 T T NNP cord-006856-b1w25ob5 1090 19 cells cell NNS cord-006856-b1w25ob5 1090 20 and and CC cord-006856-b1w25ob5 1090 21 generation generation NN cord-006856-b1w25ob5 1090 22 of of IN cord-006856-b1w25ob5 1090 23 immunoregulatory immunoregulatory NNP cord-006856-b1w25ob5 1090 24 CD25 CD25 NNP cord-006856-b1w25ob5 1090 25 + + SYM cord-006856-b1w25ob5 1090 26 CD4 CD4 NNP cord-006856-b1w25ob5 1090 27 + + CC cord-006856-b1w25ob5 1090 28 T t NN cord-006856-b1w25ob5 1090 29 cells cell NNS cord-006856-b1w25ob5 1090 30 are be VBP cord-006856-b1w25ob5 1090 31 important important JJ cord-006856-b1w25ob5 1090 32 in in IN cord-006856-b1w25ob5 1090 33 the the DT cord-006856-b1w25ob5 1090 34 process process NN cord-006856-b1w25ob5 1090 35 . . . cord-006856-b1w25ob5 1091 1 It -PRON- PRP cord-006856-b1w25ob5 1091 2 is be VBZ cord-006856-b1w25ob5 1091 3 well well RB cord-006856-b1w25ob5 1091 4 established establish VBN cord-006856-b1w25ob5 1091 5 that that DT cord-006856-b1w25ob5 1091 6 expression expression NN cord-006856-b1w25ob5 1091 7 of of IN cord-006856-b1w25ob5 1091 8 heme heme NN cord-006856-b1w25ob5 1091 9 oxygenase-1 oxygenase-1 NNP cord-006856-b1w25ob5 1091 10 ( ( -LRB- cord-006856-b1w25ob5 1091 11 HO-1 HO-1 NNP cord-006856-b1w25ob5 1091 12 ) ) -RRB- cord-006856-b1w25ob5 1091 13 can can MD cord-006856-b1w25ob5 1091 14 promote promote VB cord-006856-b1w25ob5 1091 15 the the DT cord-006856-b1w25ob5 1091 16 survival survival NN cord-006856-b1w25ob5 1091 17 of of IN cord-006856-b1w25ob5 1091 18 transplanted transplanted JJ cord-006856-b1w25ob5 1091 19 organs organ NNS cord-006856-b1w25ob5 1091 20 . . . cord-006856-b1w25ob5 1092 1 However however RB cord-006856-b1w25ob5 1092 2 , , , cord-006856-b1w25ob5 1092 3 the the DT cord-006856-b1w25ob5 1092 4 mechanisms mechanism NNS cord-006856-b1w25ob5 1092 5 underlying underlie VBG cord-006856-b1w25ob5 1092 6 this this DT cord-006856-b1w25ob5 1092 7 effect effect NN cord-006856-b1w25ob5 1092 8 remain remain VBP cord-006856-b1w25ob5 1092 9 to to TO cord-006856-b1w25ob5 1092 10 be be VB cord-006856-b1w25ob5 1092 11 elucidated elucidate VBN cord-006856-b1w25ob5 1092 12 . . . cord-006856-b1w25ob5 1093 1 We -PRON- PRP cord-006856-b1w25ob5 1093 2 hypostesized hypostesize VBD cord-006856-b1w25ob5 1093 3 that that IN cord-006856-b1w25ob5 1093 4 HO-1 HO-1 NNP cord-006856-b1w25ob5 1093 5 is be VBZ cord-006856-b1w25ob5 1093 6 required require VBN cord-006856-b1w25ob5 1093 7 for for IN cord-006856-b1w25ob5 1093 8 tolerance tolerance NN cord-006856-b1w25ob5 1093 9 induction induction NN cord-006856-b1w25ob5 1093 10 involving involve VBG cord-006856-b1w25ob5 1093 11 DSTs dst NNS cord-006856-b1w25ob5 1093 12 and and CC cord-006856-b1w25ob5 1093 13 that that IN cord-006856-b1w25ob5 1093 14 HO-1 HO-1 NNP cord-006856-b1w25ob5 1093 15 can can MD cord-006856-b1w25ob5 1093 16 magnify magnify VB cord-006856-b1w25ob5 1093 17 the the DT cord-006856-b1w25ob5 1093 18 tolerogenic tolerogenic JJ cord-006856-b1w25ob5 1093 19 effect effect NN cord-006856-b1w25ob5 1093 20 of of IN cord-006856-b1w25ob5 1093 21 DSTs dst NNS cord-006856-b1w25ob5 1093 22 . . . cord-006856-b1w25ob5 1094 1 Methods method NNS cord-006856-b1w25ob5 1094 2 . . . cord-006856-b1w25ob5 1095 1 Allograft Allograft NNP cord-006856-b1w25ob5 1095 2 survival survival NN cord-006856-b1w25ob5 1095 3 has have VBZ cord-006856-b1w25ob5 1095 4 been be VBN cord-006856-b1w25ob5 1095 5 tested test VBN cord-006856-b1w25ob5 1095 6 by by IN cord-006856-b1w25ob5 1095 7 using use VBG cord-006856-b1w25ob5 1095 8 a a DT cord-006856-b1w25ob5 1095 9 well well RB cord-006856-b1w25ob5 1095 10 established establish VBN cord-006856-b1w25ob5 1095 11 model model NN cord-006856-b1w25ob5 1095 12 of of IN cord-006856-b1w25ob5 1095 13 costimulatory costimulatory NNP cord-006856-b1w25ob5 1095 14 blockade blockade NN cord-006856-b1w25ob5 1095 15 ( ( -LRB- cord-006856-b1w25ob5 1095 16 anti anti JJ cord-006856-b1w25ob5 1095 17 - - JJ cord-006856-b1w25ob5 1095 18 CD40L cd40l JJ cord-006856-b1w25ob5 1095 19 - - : cord-006856-b1w25ob5 1095 20 Ab Ab NNP cord-006856-b1w25ob5 1095 21 ) ) -RRB- cord-006856-b1w25ob5 1095 22 plus plus CC cord-006856-b1w25ob5 1095 23 DST DST NNP cord-006856-b1w25ob5 1095 24 ( ( -LRB- cord-006856-b1w25ob5 1095 25 day day NN cord-006856-b1w25ob5 1095 26 -7 -7 NNP cord-006856-b1w25ob5 1095 27 ) ) -RRB- cord-006856-b1w25ob5 1095 28 in in IN cord-006856-b1w25ob5 1095 29 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1095 30 ( ( -LRB- cord-006856-b1w25ob5 1095 31 H-2 H-2 NNP cord-006856-b1w25ob5 1095 32 b b NN cord-006856-b1w25ob5 1095 33 ) ) -RRB- cord-006856-b1w25ob5 1095 34 heart heart NN cord-006856-b1w25ob5 1095 35 allografted allografte VBD cord-006856-b1w25ob5 1095 36 BALB BALB NNP cord-006856-b1w25ob5 1095 37 / / SYM cord-006856-b1w25ob5 1095 38 c c NN cord-006856-b1w25ob5 1095 39 ( ( -LRB- cord-006856-b1w25ob5 1095 40 H-2 H-2 NNP cord-006856-b1w25ob5 1095 41 d d NNP cord-006856-b1w25ob5 1095 42 ) ) -RRB- cord-006856-b1w25ob5 1095 43 WT WT NNP cord-006856-b1w25ob5 1095 44 and and CC cord-006856-b1w25ob5 1095 45 HO-1 HO-1 NNP cord-006856-b1w25ob5 1095 46 KO KO NNP cord-006856-b1w25ob5 1095 47 mice mouse NNS cord-006856-b1w25ob5 1095 48 . . . cord-006856-b1w25ob5 1096 1 Further further RB cord-006856-b1w25ob5 1096 2 , , , cord-006856-b1w25ob5 1096 3 HO-1 HO-1 NNP cord-006856-b1w25ob5 1096 4 activity activity NN cord-006856-b1w25ob5 1096 5 has have VBZ cord-006856-b1w25ob5 1096 6 been be VBN cord-006856-b1w25ob5 1096 7 induced induce VBN cord-006856-b1w25ob5 1096 8 ( ( -LRB- cord-006856-b1w25ob5 1096 9 by by IN cord-006856-b1w25ob5 1096 10 CoPP CoPP NNP cord-006856-b1w25ob5 1096 11 ) ) -RRB- cord-006856-b1w25ob5 1096 12 or or CC cord-006856-b1w25ob5 1096 13 suppressed suppress VBN cord-006856-b1w25ob5 1096 14 ( ( -LRB- cord-006856-b1w25ob5 1096 15 by by IN cord-006856-b1w25ob5 1096 16 ZnPP ZnPP NNP cord-006856-b1w25ob5 1096 17 ) ) -RRB- cord-006856-b1w25ob5 1096 18 in in IN cord-006856-b1w25ob5 1096 19 B6AF1 B6AF1 NNP cord-006856-b1w25ob5 1096 20 ( ( -LRB- cord-006856-b1w25ob5 1097 1 H-2 H-2 NNP cord-006856-b1w25ob5 1097 2 k k NNP cord-006856-b1w25ob5 1097 3 / / SYM cord-006856-b1w25ob5 1097 4 d d NNP cord-006856-b1w25ob5 1097 5 , , , cord-006856-b1w25ob5 1097 6 b b LS cord-006856-b1w25ob5 1097 7 ) ) -RRB- cord-006856-b1w25ob5 1097 8 mice mouse NNS cord-006856-b1w25ob5 1097 9 receiving receive VBG cord-006856-b1w25ob5 1097 10 DBA/2 DBA/2 NNP cord-006856-b1w25ob5 1097 11 ( ( -LRB- cord-006856-b1w25ob5 1097 12 H-2 H-2 NNP cord-006856-b1w25ob5 1097 13 d d NNP cord-006856-b1w25ob5 1097 14 ) ) -RRB- cord-006856-b1w25ob5 1097 15 allografts allografts NNPS cord-006856-b1w25ob5 1097 16 plus plus CC cord-006856-b1w25ob5 1097 17 DST DST NNP cord-006856-b1w25ob5 1097 18 on on IN cord-006856-b1w25ob5 1097 19 day day NN cord-006856-b1w25ob5 1097 20 0 0 CD cord-006856-b1w25ob5 1097 21 or or CC cord-006856-b1w25ob5 1097 22 day day NN cord-006856-b1w25ob5 1097 23 -7 -7 ADD cord-006856-b1w25ob5 1097 24 . . . cord-006856-b1w25ob5 1098 1 Donor donor NN cord-006856-b1w25ob5 1098 2 - - HYPH cord-006856-b1w25ob5 1098 3 specific specific JJ cord-006856-b1w25ob5 1098 4 tolerance tolerance NN cord-006856-b1w25ob5 1098 5 was be VBD cord-006856-b1w25ob5 1098 6 tested test VBN cord-006856-b1w25ob5 1098 7 by by IN cord-006856-b1w25ob5 1098 8 challenging challenge VBG cord-006856-b1w25ob5 1098 9 the the DT cord-006856-b1w25ob5 1098 10 mice mouse NNS cord-006856-b1w25ob5 1098 11 with with IN cord-006856-b1w25ob5 1098 12 a a DT cord-006856-b1w25ob5 1098 13 second second JJ cord-006856-b1w25ob5 1098 14 DBA/2 DBA/2 NNP cord-006856-b1w25ob5 1098 15 or or CC cord-006856-b1w25ob5 1098 16 third third JJ cord-006856-b1w25ob5 1098 17 - - HYPH cord-006856-b1w25ob5 1098 18 party party NN cord-006856-b1w25ob5 1098 19 FVB FVB NNP cord-006856-b1w25ob5 1098 20 ( ( -LRB- cord-006856-b1w25ob5 1098 21 H-2 h-2 NN cord-006856-b1w25ob5 1098 22 q q NNP cord-006856-b1w25ob5 1098 23 ) ) -RRB- cord-006856-b1w25ob5 1098 24 allograft allograft NN cord-006856-b1w25ob5 1098 25 . . . cord-006856-b1w25ob5 1099 1 Leukocytes Leukocytes NNP cord-006856-b1w25ob5 1099 2 ( ( -LRB- cord-006856-b1w25ob5 1099 3 depleted deplete VBN cord-006856-b1w25ob5 1099 4 or or CC cord-006856-b1w25ob5 1099 5 undepleted undeplete VBN cord-006856-b1w25ob5 1099 6 of of IN cord-006856-b1w25ob5 1099 7 CD25 CD25 NNP cord-006856-b1w25ob5 1099 8 + + SYM cord-006856-b1w25ob5 1099 9 CD4 CD4 NNP cord-006856-b1w25ob5 1099 10 + + CC cord-006856-b1w25ob5 1099 11 T t NN cord-006856-b1w25ob5 1099 12 cells cell NNS cord-006856-b1w25ob5 1099 13 ) ) -RRB- cord-006856-b1w25ob5 1099 14 from from IN cord-006856-b1w25ob5 1099 15 mice mouse NNS cord-006856-b1w25ob5 1099 16 carrying carry VBG cord-006856-b1w25ob5 1099 17 allografts allograft NNS cord-006856-b1w25ob5 1099 18 for for IN cord-006856-b1w25ob5 1099 19 > > XX cord-006856-b1w25ob5 1099 20 100 100 CD cord-006856-b1w25ob5 1099 21 days day NNS cord-006856-b1w25ob5 1099 22 were be VBD cord-006856-b1w25ob5 1099 23 adoptively adoptively RB cord-006856-b1w25ob5 1099 24 transferred transfer VBN cord-006856-b1w25ob5 1099 25 to to TO cord-006856-b1w25ob5 1099 26 sublethally sublethally RB cord-006856-b1w25ob5 1099 27 irradiated irradiate VBN cord-006856-b1w25ob5 1099 28 B6AF1 B6AF1 NNP cord-006856-b1w25ob5 1099 29 mice mouse NNS cord-006856-b1w25ob5 1099 30 receiving receive VBG cord-006856-b1w25ob5 1099 31 DBA2 DBA2 NNP cord-006856-b1w25ob5 1099 32 heart heart NN cord-006856-b1w25ob5 1099 33 allografts allograft NNS cord-006856-b1w25ob5 1099 34 . . . cord-006856-b1w25ob5 1100 1 RNA RNA NNP cord-006856-b1w25ob5 1100 2 levels level NNS cord-006856-b1w25ob5 1100 3 of of IN cord-006856-b1w25ob5 1100 4 Foxp3 foxp3 JJ cord-006856-b1w25ob5 1100 5 , , , cord-006856-b1w25ob5 1100 6 TGF TGF NNP cord-006856-b1w25ob5 1100 7 - - HYPH cord-006856-b1w25ob5 1100 8 β β NNP cord-006856-b1w25ob5 1100 9 , , , cord-006856-b1w25ob5 1100 10 IL-10 IL-10 NNP cord-006856-b1w25ob5 1100 11 and and CC cord-006856-b1w25ob5 1100 12 CTLA-4 CTLA-4 NNPS cord-006856-b1w25ob5 1100 13 have have VBP cord-006856-b1w25ob5 1100 14 been be VBN cord-006856-b1w25ob5 1100 15 assesed assese VBN cord-006856-b1w25ob5 1100 16 by by IN cord-006856-b1w25ob5 1100 17 using use VBG cord-006856-b1w25ob5 1100 18 RT RT NNP cord-006856-b1w25ob5 1100 19 - - HYPH cord-006856-b1w25ob5 1100 20 PCR PCR NNP cord-006856-b1w25ob5 1100 21 . . . cord-006856-b1w25ob5 1101 1 CD25 CD25 NNP cord-006856-b1w25ob5 1101 2 + + SYM cord-006856-b1w25ob5 1101 3 CD4 CD4 NNP cord-006856-b1w25ob5 1101 4 + + CC cord-006856-b1w25ob5 1101 5 T t NN cord-006856-b1w25ob5 1101 6 cells cell NNS cord-006856-b1w25ob5 1101 7 have have VBP cord-006856-b1w25ob5 1101 8 been be VBN cord-006856-b1w25ob5 1101 9 enumerated enumerate VBN cord-006856-b1w25ob5 1101 10 by by IN cord-006856-b1w25ob5 1101 11 flow flow NN cord-006856-b1w25ob5 1101 12 cytomerty cytomerty NN cord-006856-b1w25ob5 1101 13 . . . cord-006856-b1w25ob5 1102 1 Results result NNS cord-006856-b1w25ob5 1102 2 . . . cord-006856-b1w25ob5 1103 1 Anti anti JJ cord-006856-b1w25ob5 1103 2 - - NN cord-006856-b1w25ob5 1103 3 CD40L cd40l JJ cord-006856-b1w25ob5 1103 4 - - : cord-006856-b1w25ob5 1103 5 Ab ab NN cord-006856-b1w25ob5 1103 6 plus plus CC cord-006856-b1w25ob5 1103 7 DST dst NN cord-006856-b1w25ob5 1103 8 treatment treatment NN cord-006856-b1w25ob5 1103 9 resulted result VBD cord-006856-b1w25ob5 1103 10 in in IN cord-006856-b1w25ob5 1103 11 BALB BALB NNP cord-006856-b1w25ob5 1103 12 / / SYM cord-006856-b1w25ob5 1103 13 c c NN cord-006856-b1w25ob5 1103 14 recipients recipient NNS cord-006856-b1w25ob5 1103 15 tolerizing tolerize VBG cord-006856-b1w25ob5 1103 16 fully fully RB cord-006856-b1w25ob5 1103 17 mismatched mismatch VBD cord-006856-b1w25ob5 1103 18 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1103 19 allografts allograft NNS cord-006856-b1w25ob5 1103 20 ( ( -LRB- cord-006856-b1w25ob5 1103 21 n n NN cord-006856-b1w25ob5 1103 22 = = SYM cord-006856-b1w25ob5 1103 23 6 6 CD cord-006856-b1w25ob5 1103 24 ) ) -RRB- cord-006856-b1w25ob5 1103 25 . . . cord-006856-b1w25ob5 1104 1 However however RB cord-006856-b1w25ob5 1104 2 , , , cord-006856-b1w25ob5 1104 3 by by IN cord-006856-b1w25ob5 1104 4 using use VBG cord-006856-b1w25ob5 1104 5 HO-1-deficient ho-1-deficient CD cord-006856-b1w25ob5 1104 6 recipients recipient NNS cord-006856-b1w25ob5 1104 7 , , , cord-006856-b1w25ob5 1104 8 this this DT cord-006856-b1w25ob5 1104 9 effect effect NN cord-006856-b1w25ob5 1104 10 was be VBD cord-006856-b1w25ob5 1104 11 abrogated abrogate VBN cord-006856-b1w25ob5 1104 12 , , , cord-006856-b1w25ob5 1104 13 in in IN cord-006856-b1w25ob5 1104 14 that that DT cord-006856-b1w25ob5 1104 15 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1104 16 allografts allograft NNS cord-006856-b1w25ob5 1104 17 have have VBP cord-006856-b1w25ob5 1104 18 been be VBN cord-006856-b1w25ob5 1104 19 rejected reject VBN cord-006856-b1w25ob5 1104 20 in in IN cord-006856-b1w25ob5 1104 21 a a DT cord-006856-b1w25ob5 1104 22 similar similar JJ cord-006856-b1w25ob5 1104 23 manner manner NN cord-006856-b1w25ob5 1104 24 as as IN cord-006856-b1w25ob5 1104 25 in in IN cord-006856-b1w25ob5 1104 26 untreated untreated JJ cord-006856-b1w25ob5 1104 27 WT WT NNP cord-006856-b1w25ob5 1104 28 recipients recipient NNS cord-006856-b1w25ob5 1104 29 ( ( -LRB- cord-006856-b1w25ob5 1104 30 MST MST NNP cord-006856-b1w25ob5 1104 31 = = SYM cord-006856-b1w25ob5 1104 32 17.5 17.5 CD cord-006856-b1w25ob5 1104 33 d d NNP cord-006856-b1w25ob5 1104 34 , , , cord-006856-b1w25ob5 1104 35 n n NN cord-006856-b1w25ob5 1104 36 = = SYM cord-006856-b1w25ob5 1104 37 4 4 CD cord-006856-b1w25ob5 1104 38 ) ) -RRB- cord-006856-b1w25ob5 1104 39 . . . cord-006856-b1w25ob5 1105 1 Further further RB cord-006856-b1w25ob5 1105 2 , , , cord-006856-b1w25ob5 1105 3 DST DST NNP cord-006856-b1w25ob5 1105 4 plus plus CC cord-006856-b1w25ob5 1105 5 CoPP CoPP NNP cord-006856-b1w25ob5 1105 6 ( ( -LRB- cord-006856-b1w25ob5 1105 7 in in IN cord-006856-b1w25ob5 1105 8 contrast contrast NN cord-006856-b1w25ob5 1105 9 to to IN cord-006856-b1w25ob5 1105 10 DST DST NNP cord-006856-b1w25ob5 1105 11 plus plus CC cord-006856-b1w25ob5 1105 12 ZnPP ZnPP NNP cord-006856-b1w25ob5 1105 13 ) ) -RRB- cord-006856-b1w25ob5 1105 14 treatment treatment NN cord-006856-b1w25ob5 1105 15 resulted result VBD cord-006856-b1w25ob5 1105 16 in in IN cord-006856-b1w25ob5 1105 17 donor donor NN cord-006856-b1w25ob5 1105 18 - - HYPH cord-006856-b1w25ob5 1105 19 specific specific JJ cord-006856-b1w25ob5 1105 20 tolerance tolerance NN cord-006856-b1w25ob5 1105 21 of of IN cord-006856-b1w25ob5 1105 22 DBA/2 DBA/2 NNP cord-006856-b1w25ob5 1105 23 allografts allograft NNS cord-006856-b1w25ob5 1105 24 in in IN cord-006856-b1w25ob5 1105 25 B6AF1 B6AF1 NNP cord-006856-b1w25ob5 1105 26 recipients recipient NNS cord-006856-b1w25ob5 1105 27 ( ( -LRB- cord-006856-b1w25ob5 1105 28 n n NN cord-006856-b1w25ob5 1105 29 = = SYM cord-006856-b1w25ob5 1105 30 7 7 CD cord-006856-b1w25ob5 1105 31 ) ) -RRB- cord-006856-b1w25ob5 1105 32 . . . cord-006856-b1w25ob5 1106 1 Tolerant tolerant JJ cord-006856-b1w25ob5 1106 2 animals animal NNS cord-006856-b1w25ob5 1106 3 showed show VBD cord-006856-b1w25ob5 1106 4 significantly significantly RB cord-006856-b1w25ob5 1106 5 increased increase VBN cord-006856-b1w25ob5 1106 6 percentage percentage NN cord-006856-b1w25ob5 1106 7 of of IN cord-006856-b1w25ob5 1106 8 CD25 CD25 NNP cord-006856-b1w25ob5 1106 9 + + SYM cord-006856-b1w25ob5 1106 10 CD4 CD4 NNP cord-006856-b1w25ob5 1106 11 + + CC cord-006856-b1w25ob5 1106 12 T t NN cord-006856-b1w25ob5 1106 13 cells cell NNS cord-006856-b1w25ob5 1106 14 and and CC cord-006856-b1w25ob5 1106 15 increased increase VBN cord-006856-b1w25ob5 1106 16 levels level NNS cord-006856-b1w25ob5 1106 17 of of IN cord-006856-b1w25ob5 1106 18 Foxp3 foxp3 JJ cord-006856-b1w25ob5 1106 19 , , , cord-006856-b1w25ob5 1106 20 TGF TGF NNP cord-006856-b1w25ob5 1106 21 - - HYPH cord-006856-b1w25ob5 1106 22 β β NNP cord-006856-b1w25ob5 1106 23 , , , cord-006856-b1w25ob5 1106 24 IL-10 IL-10 NNP cord-006856-b1w25ob5 1106 25 , , , cord-006856-b1w25ob5 1106 26 and and CC cord-006856-b1w25ob5 1106 27 CTLA-4 CTLA-4 NNP cord-006856-b1w25ob5 1106 28 mRNA mRNA NNP cord-006856-b1w25ob5 1106 29 . . . cord-006856-b1w25ob5 1107 1 Adoptively adoptively RB cord-006856-b1w25ob5 1107 2 transferred transfer VBN cord-006856-b1w25ob5 1107 3 B6AF1 B6AF1 NNP cord-006856-b1w25ob5 1107 4 leukocytes leukocyte NNS cord-006856-b1w25ob5 1107 5 retrieved retrieve VBN cord-006856-b1w25ob5 1107 6 from from IN cord-006856-b1w25ob5 1107 7 the the DT cord-006856-b1w25ob5 1107 8 lymph lymph NN cord-006856-b1w25ob5 1107 9 nodes node NNS cord-006856-b1w25ob5 1107 10 and and CC cord-006856-b1w25ob5 1107 11 spleens spleen NNS cord-006856-b1w25ob5 1107 12 transferred transfer VBN cord-006856-b1w25ob5 1107 13 to to TO cord-006856-b1w25ob5 1107 14 sublethally sublethally RB cord-006856-b1w25ob5 1107 15 irradiated irradiate VBN cord-006856-b1w25ob5 1107 16 B6AF1 B6AF1 NNP cord-006856-b1w25ob5 1107 17 recipients recipient NNS cord-006856-b1w25ob5 1107 18 of of IN cord-006856-b1w25ob5 1107 19 DBA2 DBA2 NNP cord-006856-b1w25ob5 1107 20 allografts allograft NNS cord-006856-b1w25ob5 1107 21 led lead VBD cord-006856-b1w25ob5 1107 22 to to IN cord-006856-b1w25ob5 1107 23 subsequent subsequent JJ cord-006856-b1w25ob5 1107 24 allograft allograft NN cord-006856-b1w25ob5 1107 25 loss loss NN cord-006856-b1w25ob5 1107 26 ( ( -LRB- cord-006856-b1w25ob5 1107 27 MST MST NNP cord-006856-b1w25ob5 1107 28 = = NFP cord-006856-b1w25ob5 1108 1 16.7 16.7 CD cord-006856-b1w25ob5 1108 2 d d NNP cord-006856-b1w25ob5 1108 3 , , , cord-006856-b1w25ob5 1108 4 n n NN cord-006856-b1w25ob5 1108 5 = = SYM cord-006856-b1w25ob5 1108 6 6 6 CD cord-006856-b1w25ob5 1108 7 ) ) -RRB- cord-006856-b1w25ob5 1108 8 ; ; : cord-006856-b1w25ob5 1108 9 in in IN cord-006856-b1w25ob5 1108 10 contrast contrast NN cord-006856-b1w25ob5 1108 11 , , , cord-006856-b1w25ob5 1108 12 transfer transfer NN cord-006856-b1w25ob5 1108 13 of of IN cord-006856-b1w25ob5 1108 14 leukocytes leukocyte NNS cord-006856-b1w25ob5 1108 15 of of IN cord-006856-b1w25ob5 1108 16 tolerant tolerant JJ cord-006856-b1w25ob5 1108 17 ( ( -LRB- cord-006856-b1w25ob5 1108 18 Copp Copp NNP cord-006856-b1w25ob5 1108 19 plus plus CC cord-006856-b1w25ob5 1108 20 DST DST NNP cord-006856-b1w25ob5 1108 21 treated treat VBD cord-006856-b1w25ob5 1108 22 ) ) -RRB- cord-006856-b1w25ob5 1108 23 mice mouse NNS cord-006856-b1w25ob5 1108 24 led lead VBD cord-006856-b1w25ob5 1108 25 to to IN cord-006856-b1w25ob5 1108 26 indefinite indefinite JJ cord-006856-b1w25ob5 1108 27 allograft allograft NN cord-006856-b1w25ob5 1108 28 survival survival NN cord-006856-b1w25ob5 1108 29 in in IN cord-006856-b1w25ob5 1108 30 this this DT cord-006856-b1w25ob5 1108 31 model model NN cord-006856-b1w25ob5 1108 32 . . . cord-006856-b1w25ob5 1109 1 However however RB cord-006856-b1w25ob5 1109 2 , , , cord-006856-b1w25ob5 1109 3 when when WRB cord-006856-b1w25ob5 1109 4 those those DT cord-006856-b1w25ob5 1109 5 leukocytes leukocyte NNS cord-006856-b1w25ob5 1109 6 were be VBD cord-006856-b1w25ob5 1109 7 depleted deplete VBN cord-006856-b1w25ob5 1109 8 of of IN cord-006856-b1w25ob5 1109 9 CD25 CD25 NNP cord-006856-b1w25ob5 1109 10 + + SYM cord-006856-b1w25ob5 1109 11 CD4 CD4 NNP cord-006856-b1w25ob5 1109 12 + + CC cord-006856-b1w25ob5 1109 13 T t NN cord-006856-b1w25ob5 1109 14 cells cell NNS cord-006856-b1w25ob5 1109 15 , , , cord-006856-b1w25ob5 1109 16 allografts allograft NNS cord-006856-b1w25ob5 1109 17 were be VBD cord-006856-b1w25ob5 1109 18 immediately immediately RB cord-006856-b1w25ob5 1109 19 rejected reject VBN cord-006856-b1w25ob5 1109 20 ( ( -LRB- cord-006856-b1w25ob5 1109 21 MST MST NNP cord-006856-b1w25ob5 1109 22 = = NFP cord-006856-b1w25ob5 1110 1 17.7 17.7 CD cord-006856-b1w25ob5 1110 2 d d NNP cord-006856-b1w25ob5 1110 3 , , , cord-006856-b1w25ob5 1110 4 n n NN cord-006856-b1w25ob5 1110 5 = = SYM cord-006856-b1w25ob5 1110 6 5 5 CD cord-006856-b1w25ob5 1110 7 ) ) -RRB- cord-006856-b1w25ob5 1110 8 . . . cord-006856-b1w25ob5 1111 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1111 2 . . . cord-006856-b1w25ob5 1112 1 HO-1 HO-1 NNP cord-006856-b1w25ob5 1113 1 in in IN cord-006856-b1w25ob5 1113 2 a a DT cord-006856-b1w25ob5 1113 3 graft graft NN cord-006856-b1w25ob5 1113 4 recipient recipient NN cord-006856-b1w25ob5 1113 5 can can MD cord-006856-b1w25ob5 1113 6 be be VB cord-006856-b1w25ob5 1113 7 critical critical JJ cord-006856-b1w25ob5 1113 8 for for IN cord-006856-b1w25ob5 1113 9 long long JJ cord-006856-b1w25ob5 1113 10 - - HYPH cord-006856-b1w25ob5 1113 11 term term NN cord-006856-b1w25ob5 1113 12 graft graft NN cord-006856-b1w25ob5 1113 13 survival survival NN cord-006856-b1w25ob5 1113 14 and and CC cord-006856-b1w25ob5 1113 15 for for IN cord-006856-b1w25ob5 1113 16 induction induction NN cord-006856-b1w25ob5 1113 17 of of IN cord-006856-b1w25ob5 1113 18 tolerance tolerance NN cord-006856-b1w25ob5 1113 19 . . . cord-006856-b1w25ob5 1114 1 This this DT cord-006856-b1w25ob5 1114 2 mainly mainly RB cord-006856-b1w25ob5 1114 3 is be VBZ cord-006856-b1w25ob5 1114 4 mediated mediate VBN cord-006856-b1w25ob5 1114 5 by by IN cord-006856-b1w25ob5 1114 6 generation generation NN cord-006856-b1w25ob5 1114 7 of of IN cord-006856-b1w25ob5 1114 8 CD25 CD25 NNP cord-006856-b1w25ob5 1115 1 + + CC cord-006856-b1w25ob5 1115 2 CD4 CD4 NNP cord-006856-b1w25ob5 1115 3 + + CC cord-006856-b1w25ob5 1115 4 T t NN cord-006856-b1w25ob5 1115 5 cells cell NNS cord-006856-b1w25ob5 1115 6 ( ( -LRB- cord-006856-b1w25ob5 1115 7 T T NNP cord-006856-b1w25ob5 1115 8 regs reg NNS cord-006856-b1w25ob5 1115 9 ) ) -RRB- cord-006856-b1w25ob5 1115 10 . . . cord-006856-b1w25ob5 1116 1 Modulation modulation NN cord-006856-b1w25ob5 1116 2 of of IN cord-006856-b1w25ob5 1116 3 HO-1 HO-1 NNP cord-006856-b1w25ob5 1116 4 expression expression NN cord-006856-b1w25ob5 1116 5 and and CC cord-006856-b1w25ob5 1116 6 activity activity NN cord-006856-b1w25ob5 1116 7 may may MD cord-006856-b1w25ob5 1116 8 be be VB cord-006856-b1w25ob5 1116 9 used use VBN cord-006856-b1w25ob5 1116 10 therapeutically therapeutically RB cord-006856-b1w25ob5 1116 11 to to TO cord-006856-b1w25ob5 1116 12 promote promote VB cord-006856-b1w25ob5 1116 13 graft graft NN cord-006856-b1w25ob5 1116 14 tolerance tolerance NN cord-006856-b1w25ob5 1116 15 . . . cord-006856-b1w25ob5 1117 1 Background background NN cord-006856-b1w25ob5 1117 2 . . . cord-006856-b1w25ob5 1118 1 Human human JJ cord-006856-b1w25ob5 1118 2 Immunoglobuline Immunoglobuline NNP cord-006856-b1w25ob5 1118 3 ( ( -LRB- cord-006856-b1w25ob5 1118 4 IvIg IvIg NNP cord-006856-b1w25ob5 1118 5 ) ) -RRB- cord-006856-b1w25ob5 1118 6 has have VBZ cord-006856-b1w25ob5 1118 7 been be VBN cord-006856-b1w25ob5 1118 8 advocated advocate VBN cord-006856-b1w25ob5 1118 9 in in IN cord-006856-b1w25ob5 1118 10 the the DT cord-006856-b1w25ob5 1118 11 treatment treatment NN cord-006856-b1w25ob5 1118 12 of of IN cord-006856-b1w25ob5 1118 13 acute acute JJ cord-006856-b1w25ob5 1118 14 rejection rejection NN cord-006856-b1w25ob5 1118 15 in in IN cord-006856-b1w25ob5 1118 16 allograft allograft NN cord-006856-b1w25ob5 1118 17 transplantation transplantation NN cord-006856-b1w25ob5 1118 18 and and CC cord-006856-b1w25ob5 1118 19 treatment treatment NN cord-006856-b1w25ob5 1118 20 of of IN cord-006856-b1w25ob5 1118 21 sepsis sepsis NN cord-006856-b1w25ob5 1118 22 . . . cord-006856-b1w25ob5 1119 1 Mechanisms mechanism NNS cord-006856-b1w25ob5 1119 2 describing describe VBG cord-006856-b1w25ob5 1119 3 the the DT cord-006856-b1w25ob5 1119 4 immune immune JJ cord-006856-b1w25ob5 1119 5 modulatory modulatory JJ cord-006856-b1w25ob5 1119 6 activity activity NN cord-006856-b1w25ob5 1119 7 are be VBP cord-006856-b1w25ob5 1119 8 however however RB cord-006856-b1w25ob5 1119 9 scarce scarce JJ cord-006856-b1w25ob5 1119 10 . . . cord-006856-b1w25ob5 1120 1 We -PRON- PRP cord-006856-b1w25ob5 1120 2 sought seek VBD cord-006856-b1w25ob5 1120 3 to to TO cord-006856-b1w25ob5 1120 4 investigate investigate VB cord-006856-b1w25ob5 1120 5 immune immune JJ cord-006856-b1w25ob5 1120 6 suppressive suppressive JJ cord-006856-b1w25ob5 1120 7 properties property NNS cord-006856-b1w25ob5 1120 8 of of IN cord-006856-b1w25ob5 1120 9 pooled pool VBN cord-006856-b1w25ob5 1120 10 human human JJ cord-006856-b1w25ob5 1120 11 Immuneglobuline Immuneglobuline NNP cord-006856-b1w25ob5 1120 12 ( ( -LRB- cord-006856-b1w25ob5 1120 13 Ig Ig NNP cord-006856-b1w25ob5 1120 14 ) ) -RRB- cord-006856-b1w25ob5 1120 15 , , , cord-006856-b1w25ob5 1120 16 unspecific unspecific JJ cord-006856-b1w25ob5 1120 17 Fc Fc NNP cord-006856-b1w25ob5 1120 18 and and CC cord-006856-b1w25ob5 1120 19 Fab Fab NNP cord-006856-b1w25ob5 1120 20 fragments fragment NNS cord-006856-b1w25ob5 1120 21 and and CC cord-006856-b1w25ob5 1120 22 their -PRON- PRP$ cord-006856-b1w25ob5 1120 23 respective respective JJ cord-006856-b1w25ob5 1120 24 ligands ligand NNS cord-006856-b1w25ob5 1120 25 by by IN cord-006856-b1w25ob5 1120 26 allogeneic allogeneic NN cord-006856-b1w25ob5 1120 27 blastogenesis blastogenesis NN cord-006856-b1w25ob5 1120 28 assays assay NNS cord-006856-b1w25ob5 1120 29 . . . cord-006856-b1w25ob5 1121 1 Methods method NNS cord-006856-b1w25ob5 1121 2 . . . cord-006856-b1w25ob5 1122 1 Human human JJ cord-006856-b1w25ob5 1122 2 mixed mixed JJ cord-006856-b1w25ob5 1122 3 lymphocyte lymphocyte NN cord-006856-b1w25ob5 1122 4 reactions reaction NNS cord-006856-b1w25ob5 1122 5 ( ( -LRB- cord-006856-b1w25ob5 1122 6 MLR MLR NNP cord-006856-b1w25ob5 1122 7 ) ) -RRB- cord-006856-b1w25ob5 1122 8 were be VBD cord-006856-b1w25ob5 1122 9 performed perform VBN cord-006856-b1w25ob5 1122 10 . . . cord-006856-b1w25ob5 1123 1 In in IN cord-006856-b1w25ob5 1123 2 detail detail NN cord-006856-b1w25ob5 1123 3 peripheral peripheral JJ cord-006856-b1w25ob5 1123 4 blood blood NN cord-006856-b1w25ob5 1123 5 mononuclear mononuclear NN cord-006856-b1w25ob5 1123 6 cells cell NNS cord-006856-b1w25ob5 1123 7 ( ( -LRB- cord-006856-b1w25ob5 1123 8 PBMCs pbmc NNS cord-006856-b1w25ob5 1123 9 ) ) -RRB- cord-006856-b1w25ob5 1123 10 were be VBD cord-006856-b1w25ob5 1123 11 purified purify VBN cord-006856-b1w25ob5 1123 12 from from IN cord-006856-b1w25ob5 1123 13 5 5 CD cord-006856-b1w25ob5 1123 14 donors donor NNS cord-006856-b1w25ob5 1123 15 by by IN cord-006856-b1w25ob5 1123 16 Ficoll Ficoll NNP cord-006856-b1w25ob5 1123 17 density density NN cord-006856-b1w25ob5 1123 18 gradient gradient NN cord-006856-b1w25ob5 1123 19 centrifugation centrifugation NN cord-006856-b1w25ob5 1123 20 ( ( -LRB- cord-006856-b1w25ob5 1123 21 Amersham Amersham NNP cord-006856-b1w25ob5 1123 22 Biosciences Biosciences NNP cord-006856-b1w25ob5 1123 23 , , , cord-006856-b1w25ob5 1123 24 Buckinghamshire Buckinghamshire NNP cord-006856-b1w25ob5 1123 25 , , , cord-006856-b1w25ob5 1123 26 England England NNP cord-006856-b1w25ob5 1123 27 ) ) -RRB- cord-006856-b1w25ob5 1123 28 . . . cord-006856-b1w25ob5 1124 1 100,000 100,000 CD cord-006856-b1w25ob5 1124 2 cells cell NNS cord-006856-b1w25ob5 1124 3 per per IN cord-006856-b1w25ob5 1124 4 well well RB cord-006856-b1w25ob5 1124 5 were be VBD cord-006856-b1w25ob5 1124 6 stimulated stimulate VBN cord-006856-b1w25ob5 1124 7 with with IN cord-006856-b1w25ob5 1124 8 100,000 100,000 CD cord-006856-b1w25ob5 1124 9 radiated radiate VBN cord-006856-b1w25ob5 1124 10 PBMC PBMC NNP cord-006856-b1w25ob5 1124 11 ( ( -LRB- cord-006856-b1w25ob5 1124 12 60 60 CD cord-006856-b1w25ob5 1124 13 Gy Gy NNP cord-006856-b1w25ob5 1124 14 ) ) -RRB- cord-006856-b1w25ob5 1124 15 and and CC cord-006856-b1w25ob5 1124 16 incubated incubate VBN cord-006856-b1w25ob5 1124 17 for for IN cord-006856-b1w25ob5 1124 18 5 5 CD cord-006856-b1w25ob5 1124 19 days day NNS cord-006856-b1w25ob5 1124 20 at at IN cord-006856-b1w25ob5 1124 21 37 37 CD cord-006856-b1w25ob5 1124 22 ° ° NN cord-006856-b1w25ob5 1124 23 C c NN cord-006856-b1w25ob5 1124 24 together together RB cord-006856-b1w25ob5 1124 25 with with IN cord-006856-b1w25ob5 1124 26 unspecific unspecific JJ cord-006856-b1w25ob5 1124 27 IgG IgG NNP cord-006856-b1w25ob5 1124 28 , , , cord-006856-b1w25ob5 1124 29 IgM IgM NNP cord-006856-b1w25ob5 1124 30 ( ( -LRB- cord-006856-b1w25ob5 1124 31 both both DT cord-006856-b1w25ob5 1124 32 Sigma Sigma NNP cord-006856-b1w25ob5 1124 33 - - HYPH cord-006856-b1w25ob5 1124 34 Alderich Alderich NNP cord-006856-b1w25ob5 1124 35 , , , cord-006856-b1w25ob5 1124 36 St. St. NNP cord-006856-b1w25ob5 1124 37 Louis Louis NNP cord-006856-b1w25ob5 1124 38 , , , cord-006856-b1w25ob5 1124 39 MO MO NNP cord-006856-b1w25ob5 1124 40 ) ) -RRB- cord-006856-b1w25ob5 1124 41 , , , cord-006856-b1w25ob5 1124 42 anti anti JJ cord-006856-b1w25ob5 1124 43 - - JJ cord-006856-b1w25ob5 1124 44 CD32 cd32 JJ cord-006856-b1w25ob5 1124 45 ( ( -LRB- cord-006856-b1w25ob5 1124 46 Lab Lab NNP cord-006856-b1w25ob5 1124 47 Vision Vision NNP cord-006856-b1w25ob5 1124 48 , , , cord-006856-b1w25ob5 1124 49 Fremont Fremont NNP cord-006856-b1w25ob5 1124 50 , , , cord-006856-b1w25ob5 1124 51 CA CA NNP cord-006856-b1w25ob5 1124 52 ) ) -RRB- cord-006856-b1w25ob5 1124 53 and and CC cord-006856-b1w25ob5 1124 54 anti anti NNP cord-006856-b1w25ob5 1124 55 - - NNP cord-006856-b1w25ob5 1124 56 CD64 CD64 NNP cord-006856-b1w25ob5 1124 57 ( ( -LRB- cord-006856-b1w25ob5 1124 58 Chemicon Chemicon NNP cord-006856-b1w25ob5 1124 59 , , , cord-006856-b1w25ob5 1124 60 Temecula Temecula NNP cord-006856-b1w25ob5 1124 61 , , , cord-006856-b1w25ob5 1124 62 CA CA NNP cord-006856-b1w25ob5 1124 63 ) ) -RRB- cord-006856-b1w25ob5 1124 64 in in IN cord-006856-b1w25ob5 1124 65 a a DT cord-006856-b1w25ob5 1124 66 dose dose NN cord-006856-b1w25ob5 1124 67 - - HYPH cord-006856-b1w25ob5 1124 68 dependent dependent JJ cord-006856-b1w25ob5 1124 69 fashion fashion NN cord-006856-b1w25ob5 1124 70 . . . cord-006856-b1w25ob5 1125 1 Before before IN cord-006856-b1w25ob5 1125 2 harvesting harvesting NN cord-006856-b1w25ob5 1125 3 cells cell NNS cord-006856-b1w25ob5 1125 4 were be VBD cord-006856-b1w25ob5 1125 5 pulsed pulse VBN cord-006856-b1w25ob5 1125 6 for for IN cord-006856-b1w25ob5 1125 7 18 18 CD cord-006856-b1w25ob5 1125 8 h h NN cord-006856-b1w25ob5 1125 9 with with IN cord-006856-b1w25ob5 1125 10 [ [ -LRB- cord-006856-b1w25ob5 1125 11 3 3 CD cord-006856-b1w25ob5 1125 12 H]thymidine H]thymidine NNP cord-006856-b1w25ob5 1125 13 ( ( -LRB- cord-006856-b1w25ob5 1125 14 3.7 3.7 CD cord-006856-b1w25ob5 1125 15 × × NN cord-006856-b1w25ob5 1125 16 10 10 CD cord-006856-b1w25ob5 1125 17 4 4 CD cord-006856-b1w25ob5 1125 18 Bq Bq NNP cord-006856-b1w25ob5 1125 19 / / SYM cord-006856-b1w25ob5 1125 20 well well RB cord-006856-b1w25ob5 1125 21 ) ) -RRB- cord-006856-b1w25ob5 1125 22 and and CC cord-006856-b1w25ob5 1125 23 the the DT cord-006856-b1w25ob5 1125 24 [ [ -LRB- cord-006856-b1w25ob5 1125 25 3 3 CD cord-006856-b1w25ob5 1125 26 H]thymidine H]thymidine NNP cord-006856-b1w25ob5 1125 27 uptake uptake NN cord-006856-b1w25ob5 1125 28 was be VBD cord-006856-b1w25ob5 1125 29 measured measure VBN cord-006856-b1w25ob5 1125 30 in in IN cord-006856-b1w25ob5 1125 31 a a DT cord-006856-b1w25ob5 1125 32 liquid liquid JJ cord-006856-b1w25ob5 1125 33 scintillation scintillation NN cord-006856-b1w25ob5 1125 34 counter counter RB cord-006856-b1w25ob5 1125 35 . . . cord-006856-b1w25ob5 1126 1 Results result NNS cord-006856-b1w25ob5 1126 2 . . . cord-006856-b1w25ob5 1127 1 The the DT cord-006856-b1w25ob5 1127 2 addition addition NN cord-006856-b1w25ob5 1127 3 of of IN cord-006856-b1w25ob5 1127 4 pooled pool VBN cord-006856-b1w25ob5 1127 5 human human JJ cord-006856-b1w25ob5 1127 6 IgG IgG NNP cord-006856-b1w25ob5 1127 7 and and CC cord-006856-b1w25ob5 1127 8 IgM IgM NNP cord-006856-b1w25ob5 1127 9 to to TO cord-006856-b1w25ob5 1127 10 allogeneic allogeneic VB cord-006856-b1w25ob5 1127 11 stimulated stimulated JJ cord-006856-b1w25ob5 1127 12 cells cell NNS cord-006856-b1w25ob5 1127 13 both both DT cord-006856-b1w25ob5 1127 14 resulted result VBD cord-006856-b1w25ob5 1127 15 in in IN cord-006856-b1w25ob5 1127 16 a a DT cord-006856-b1w25ob5 1127 17 significant significant JJ cord-006856-b1w25ob5 1127 18 and and CC cord-006856-b1w25ob5 1127 19 dose dose JJ cord-006856-b1w25ob5 1127 20 dependent dependent JJ cord-006856-b1w25ob5 1127 21 decrease decrease NN cord-006856-b1w25ob5 1127 22 of of IN cord-006856-b1w25ob5 1127 23 proliferation proliferation NN cord-006856-b1w25ob5 1127 24 , , , cord-006856-b1w25ob5 1127 25 although although IN cord-006856-b1w25ob5 1127 26 the the DT cord-006856-b1w25ob5 1127 27 suppressive suppressive JJ cord-006856-b1w25ob5 1127 28 properties property NNS cord-006856-b1w25ob5 1127 29 of of IN cord-006856-b1w25ob5 1127 30 IgM IgM NNP cord-006856-b1w25ob5 1127 31 was be VBD cord-006856-b1w25ob5 1127 32 greater great JJR cord-006856-b1w25ob5 1127 33 as as IN cord-006856-b1w25ob5 1127 34 compared compare VBN cord-006856-b1w25ob5 1127 35 to to IN cord-006856-b1w25ob5 1127 36 IgG IgG NNP cord-006856-b1w25ob5 1127 37 ( ( -LRB- cord-006856-b1w25ob5 1127 38 both both DT cord-006856-b1w25ob5 1127 39 , , , cord-006856-b1w25ob5 1127 40 P p NN cord-006856-b1w25ob5 1127 41 < < XX cord-006856-b1w25ob5 1127 42 0.0001 0.0001 CD cord-006856-b1w25ob5 1127 43 ) ) -RRB- cord-006856-b1w25ob5 1127 44 . . . cord-006856-b1w25ob5 1128 1 To to TO cord-006856-b1w25ob5 1128 2 investigate investigate VB cord-006856-b1w25ob5 1128 3 whether whether IN cord-006856-b1w25ob5 1128 4 this this DT cord-006856-b1w25ob5 1128 5 effect effect NN cord-006856-b1w25ob5 1128 6 was be VBD cord-006856-b1w25ob5 1128 7 partly partly RB cord-006856-b1w25ob5 1128 8 related relate VBN cord-006856-b1w25ob5 1128 9 to to IN cord-006856-b1w25ob5 1128 10 Fc Fc NNP cord-006856-b1w25ob5 1128 11 receptor receptor NN cord-006856-b1w25ob5 1128 12 involvement involvement NN cord-006856-b1w25ob5 1128 13 we -PRON- PRP cord-006856-b1w25ob5 1128 14 blocked block VBD cord-006856-b1w25ob5 1128 15 CD32 CD32 NNP cord-006856-b1w25ob5 1128 16 and and CC cord-006856-b1w25ob5 1128 17 CD64 CD64 NNP cord-006856-b1w25ob5 1128 18 on on IN cord-006856-b1w25ob5 1128 19 antigen antigen NN cord-006856-b1w25ob5 1128 20 presenting present VBG cord-006856-b1w25ob5 1128 21 cells cell NNS cord-006856-b1w25ob5 1128 22 ( ( -LRB- cord-006856-b1w25ob5 1128 23 APCs apc NNS cord-006856-b1w25ob5 1128 24 ) ) -RRB- cord-006856-b1w25ob5 1128 25 , , , cord-006856-b1w25ob5 1128 26 known know VBN cord-006856-b1w25ob5 1128 27 receptors receptor NNS cord-006856-b1w25ob5 1128 28 in in IN cord-006856-b1w25ob5 1128 29 the the DT cord-006856-b1w25ob5 1128 30 activation activation NN cord-006856-b1w25ob5 1128 31 of of IN cord-006856-b1w25ob5 1128 32 MLR MLR NNP cord-006856-b1w25ob5 1128 33 . . . cord-006856-b1w25ob5 1129 1 Surprisingly surprisingly RB cord-006856-b1w25ob5 1129 2 , , , cord-006856-b1w25ob5 1129 3 this this DT cord-006856-b1w25ob5 1129 4 assay assay NN cord-006856-b1w25ob5 1129 5 demonstrated demonstrate VBD cord-006856-b1w25ob5 1129 6 that that IN cord-006856-b1w25ob5 1129 7 sole sole JJ cord-006856-b1w25ob5 1129 8 Fc Fc NNP cord-006856-b1w25ob5 1129 9 blocking block VBG cord-006856-b1w25ob5 1129 10 ( ( -LRB- cord-006856-b1w25ob5 1129 11 high high JJ cord-006856-b1w25ob5 1129 12 - - HYPH cord-006856-b1w25ob5 1129 13 and and CC cord-006856-b1w25ob5 1129 14 low low JJ cord-006856-b1w25ob5 1129 15 affinity affinity NN cord-006856-b1w25ob5 1129 16 Fc Fc NNP cord-006856-b1w25ob5 1129 17 receptors receptor NNS cord-006856-b1w25ob5 1129 18 ) ) -RRB- cord-006856-b1w25ob5 1129 19 resulted result VBD cord-006856-b1w25ob5 1129 20 in in IN cord-006856-b1w25ob5 1129 21 a a DT cord-006856-b1w25ob5 1129 22 significant significant JJ cord-006856-b1w25ob5 1129 23 downregulation downregulation NN cord-006856-b1w25ob5 1129 24 of of IN cord-006856-b1w25ob5 1129 25 allogeneic allogeneic NN cord-006856-b1w25ob5 1129 26 response response NN cord-006856-b1w25ob5 1129 27 in in IN cord-006856-b1w25ob5 1129 28 vitro vitro FW cord-006856-b1w25ob5 1129 29 ( ( -LRB- cord-006856-b1w25ob5 1129 30 both both DT cord-006856-b1w25ob5 1129 31 , , , cord-006856-b1w25ob5 1129 32 P p NN cord-006856-b1w25ob5 1129 33 < < XX cord-006856-b1w25ob5 1129 34 0.001 0.001 CD cord-006856-b1w25ob5 1129 35 ) ) -RRB- cord-006856-b1w25ob5 1129 36 . . . cord-006856-b1w25ob5 1130 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1130 2 . . . cord-006856-b1w25ob5 1131 1 Our -PRON- PRP$ cord-006856-b1w25ob5 1131 2 data data NN cord-006856-b1w25ob5 1131 3 evidence evidence NN cord-006856-b1w25ob5 1131 4 that that IN cord-006856-b1w25ob5 1131 5 the the DT cord-006856-b1w25ob5 1131 6 addition addition NN cord-006856-b1w25ob5 1131 7 of of IN cord-006856-b1w25ob5 1131 8 unspecific unspecific JJ cord-006856-b1w25ob5 1131 9 immune immune JJ cord-006856-b1w25ob5 1131 10 globulines globuline NNS cord-006856-b1w25ob5 1131 11 results result NNS cord-006856-b1w25ob5 1131 12 in in IN cord-006856-b1w25ob5 1131 13 a a DT cord-006856-b1w25ob5 1131 14 reduction reduction NN cord-006856-b1w25ob5 1131 15 of of IN cord-006856-b1w25ob5 1131 16 proliferation proliferation NN cord-006856-b1w25ob5 1131 17 in in IN cord-006856-b1w25ob5 1131 18 in in FW cord-006856-b1w25ob5 1131 19 vitro vitro FW cord-006856-b1w25ob5 1131 20 allogeneic allogeneic IN cord-006856-b1w25ob5 1131 21 blastogenesis blastogenesis NN cord-006856-b1w25ob5 1131 22 assays assay NNS cord-006856-b1w25ob5 1131 23 and and CC cord-006856-b1w25ob5 1131 24 is be VBZ cord-006856-b1w25ob5 1131 25 partly partly RB cord-006856-b1w25ob5 1131 26 Fc Fc NNP cord-006856-b1w25ob5 1131 27 receptor receptor NN cord-006856-b1w25ob5 1131 28 dependent dependent JJ cord-006856-b1w25ob5 1131 29 . . . cord-006856-b1w25ob5 1132 1 These these DT cord-006856-b1w25ob5 1132 2 results result NNS cord-006856-b1w25ob5 1132 3 corroborate corroborate VBP cord-006856-b1w25ob5 1132 4 the the DT cord-006856-b1w25ob5 1132 5 clinical clinical JJ cord-006856-b1w25ob5 1132 6 success success NN cord-006856-b1w25ob5 1132 7 of of IN cord-006856-b1w25ob5 1132 8 IvIg IvIg NNP cord-006856-b1w25ob5 1132 9 and and CC cord-006856-b1w25ob5 1132 10 pooled pool VBD cord-006856-b1w25ob5 1132 11 IgM IgM NNP cord-006856-b1w25ob5 1132 12 in in IN cord-006856-b1w25ob5 1132 13 the the DT cord-006856-b1w25ob5 1132 14 treatment treatment NN cord-006856-b1w25ob5 1132 15 of of IN cord-006856-b1w25ob5 1132 16 solid solid JJ cord-006856-b1w25ob5 1132 17 organ organ NN cord-006856-b1w25ob5 1132 18 allograft allograft NN cord-006856-b1w25ob5 1132 19 rejection rejection NN cord-006856-b1w25ob5 1132 20 and and CC cord-006856-b1w25ob5 1132 21 cautions caution VBZ cord-006856-b1w25ob5 1132 22 the the DT cord-006856-b1w25ob5 1132 23 utilization utilization NN cord-006856-b1w25ob5 1132 24 of of IN cord-006856-b1w25ob5 1132 25 immune immune JJ cord-006856-b1w25ob5 1132 26 globulines globuline NNS cord-006856-b1w25ob5 1132 27 in in IN cord-006856-b1w25ob5 1132 28 immune immune JJ cord-006856-b1w25ob5 1132 29 suppressed suppress VBN cord-006856-b1w25ob5 1132 30 septic septic JJ cord-006856-b1w25ob5 1132 31 patients patient NNS cord-006856-b1w25ob5 1132 32 . . . cord-006856-b1w25ob5 1133 1 Die die VB cord-006856-b1w25ob5 1133 2 Interaktion Interaktion NNP cord-006856-b1w25ob5 1133 3 professioneller professioneller NN cord-006856-b1w25ob5 1133 4 antigen antigen NN cord-006856-b1w25ob5 1133 5 - - HYPH cord-006856-b1w25ob5 1133 6 präsentierender präsentierender NN cord-006856-b1w25ob5 1133 7 Zellen Zellen NNP cord-006856-b1w25ob5 1133 8 mit mit NNP cord-006856-b1w25ob5 1133 9 allogenen allogenen NNP cord-006856-b1w25ob5 1133 10 T T NNP cord-006856-b1w25ob5 1133 11 - - HYPH cord-006856-b1w25ob5 1133 12 Zellen Zellen NNP cord-006856-b1w25ob5 1133 13 resultiert resultiert NN cord-006856-b1w25ob5 1133 14 in in IN cord-006856-b1w25ob5 1133 15 der der NNP cord-006856-b1w25ob5 1133 16 Ausbildung Ausbildung NNP cord-006856-b1w25ob5 1133 17 der der NN cord-006856-b1w25ob5 1133 18 sog sog NNP cord-006856-b1w25ob5 1133 19 . . . cord-006856-b1w25ob5 1134 1 immunologischen immunologischen NNP cord-006856-b1w25ob5 1134 2 Synapse Synapse NNP cord-006856-b1w25ob5 1134 3 ( ( -LRB- cord-006856-b1w25ob5 1134 4 IS be VBZ cord-006856-b1w25ob5 1134 5 ) ) -RRB- cord-006856-b1w25ob5 1134 6 , , , cord-006856-b1w25ob5 1134 7 welche welche NNP cord-006856-b1w25ob5 1134 8 für für NNP cord-006856-b1w25ob5 1134 9 die die VBP cord-006856-b1w25ob5 1134 10 effiziente effiziente NNP cord-006856-b1w25ob5 1135 1 Aktivierung Aktivierung NNP cord-006856-b1w25ob5 1135 2 von von NNP cord-006856-b1w25ob5 1135 3 T T NNP cord-006856-b1w25ob5 1135 4 - - HYPH cord-006856-b1w25ob5 1135 5 Zellen Zellen NNP cord-006856-b1w25ob5 1135 6 und und IN cord-006856-b1w25ob5 1135 7 damit damit NNP cord-006856-b1w25ob5 1135 8 letztlich letztlich NNP cord-006856-b1w25ob5 1135 9 für für NNP cord-006856-b1w25ob5 1135 10 die die VBP cord-006856-b1w25ob5 1136 1 Transplantatabstoßung Transplantatabstoßung NNP cord-006856-b1w25ob5 1136 2 essentiell essentiell NN cord-006856-b1w25ob5 1136 3 ist ist NN cord-006856-b1w25ob5 1136 4 . . . cord-006856-b1w25ob5 1137 1 I -PRON- PRP cord-006856-b1w25ob5 1137 2 m be VBP cord-006856-b1w25ob5 1137 3 Rahmen Rahmen NNP cord-006856-b1w25ob5 1137 4 der der NN cord-006856-b1w25ob5 1137 5 IS be VBZ cord-006856-b1w25ob5 1138 1 werden werden NNP cord-006856-b1w25ob5 1138 2 der der NNP cord-006856-b1w25ob5 1138 3 T T NNP cord-006856-b1w25ob5 1138 4 - - HYPH cord-006856-b1w25ob5 1138 5 Zellrezeptor Zellrezeptor NNP cord-006856-b1w25ob5 1138 6 / / SYM cord-006856-b1w25ob5 1138 7 CD3-Komplex CD3-Komplex NNP cord-006856-b1w25ob5 1138 8 , , , cord-006856-b1w25ob5 1138 9 kostimulatorische kostimulatorische NNP cord-006856-b1w25ob5 1138 10 wie wie NNP cord-006856-b1w25ob5 1138 11 Adhäsionsmoleküle Adhäsionsmoleküle NNP cord-006856-b1w25ob5 1138 12 und und IN cord-006856-b1w25ob5 1138 13 Komponenten Komponenten NNP cord-006856-b1w25ob5 1138 14 des des NNP cord-006856-b1w25ob5 1138 15 Zytoskeletts Zytoskeletts NNP cord-006856-b1w25ob5 1138 16 in in IN cord-006856-b1w25ob5 1138 17 die die NN cord-006856-b1w25ob5 1139 1 Kontaktzone Kontaktzone NNP cord-006856-b1w25ob5 1139 2 des des NNP cord-006856-b1w25ob5 1139 3 MHC MHC NNP cord-006856-b1w25ob5 1139 4 - - HYPH cord-006856-b1w25ob5 1139 5 TCR TCR NNP cord-006856-b1w25ob5 1139 6 / / SYM cord-006856-b1w25ob5 1139 7 CD3-Komplexes CD3-Komplexes NNP cord-006856-b1w25ob5 1139 8 der der NNP cord-006856-b1w25ob5 1139 9 IS be VBZ cord-006856-b1w25ob5 1139 10 rekrutiert rekrutiert JJ cord-006856-b1w25ob5 1139 11 . . . cord-006856-b1w25ob5 1140 1 Der Der NNP cord-006856-b1w25ob5 1140 2 Einfluss Einfluss NNP cord-006856-b1w25ob5 1140 3 von von NNP cord-006856-b1w25ob5 1140 4 gängigen gängigen NNP cord-006856-b1w25ob5 1140 5 Immunsuppressiva Immunsuppressiva NNP cord-006856-b1w25ob5 1140 6 , , , cord-006856-b1w25ob5 1140 7 die die VB cord-006856-b1w25ob5 1140 8 zur zur NNP cord-006856-b1w25ob5 1140 9 Prävention Prävention NNP cord-006856-b1w25ob5 1140 10 der der NN cord-006856-b1w25ob5 1140 11 allogenen allogenen NNP cord-006856-b1w25ob5 1140 12 Organabstoßung Organabstoßung NNP cord-006856-b1w25ob5 1140 13 klinisch klinisch NNP cord-006856-b1w25ob5 1140 14 verwendet verwendet NNP cord-006856-b1w25ob5 1140 15 werden werden NNP cord-006856-b1w25ob5 1141 1 , , , cord-006856-b1w25ob5 1141 2 auf auf NNP cord-006856-b1w25ob5 1141 3 die die VBP cord-006856-b1w25ob5 1142 1 IS be VBZ cord-006856-b1w25ob5 1143 1 -Evolution -Evolution : cord-006856-b1w25ob5 1143 2 ist ist NNP cord-006856-b1w25ob5 1143 3 bislang bislang VBD cord-006856-b1w25ob5 1143 4 unbekannt unbekannt JJ cord-006856-b1w25ob5 1143 5 . . . cord-006856-b1w25ob5 1144 1 In in IN cord-006856-b1w25ob5 1144 2 dieser dieser NNP cord-006856-b1w25ob5 1144 3 Studie Studie NNP cord-006856-b1w25ob5 1144 4 zeigen zeigen NNP cord-006856-b1w25ob5 1144 5 wir wir NNP cord-006856-b1w25ob5 1144 6 erstmals erstmals NNP cord-006856-b1w25ob5 1144 7 , , , cord-006856-b1w25ob5 1144 8 dass dass NNP cord-006856-b1w25ob5 1144 9 Kalzineurinhemmer Kalzineurinhemmer NNP cord-006856-b1w25ob5 1144 10 wie wie NNP cord-006856-b1w25ob5 1144 11 CsA CsA NNP cord-006856-b1w25ob5 1145 1 oder oder NNP cord-006856-b1w25ob5 1145 2 FK506 FK506 NNP cord-006856-b1w25ob5 1145 3 , , , cord-006856-b1w25ob5 1145 4 aber aber NNP cord-006856-b1w25ob5 1145 5 nicht nicht NNP cord-006856-b1w25ob5 1145 6 mTOR mTOR NNP cord-006856-b1w25ob5 1145 7 - - HYPH cord-006856-b1w25ob5 1145 8 Inhibitoren Inhibitoren NNP cord-006856-b1w25ob5 1146 1 , , , cord-006856-b1w25ob5 1146 2 selektiv selektiv NNP cord-006856-b1w25ob5 1146 3 die die VB cord-006856-b1w25ob5 1147 1 Rekrutierung Rekrutierung NNP cord-006856-b1w25ob5 1147 2 des des NNP cord-006856-b1w25ob5 1147 3 TCR TCR NNP cord-006856-b1w25ob5 1147 4 / / SYM cord-006856-b1w25ob5 1147 5 CD3-Komplexes CD3-Komplexes NNP cord-006856-b1w25ob5 1147 6 in in IN cord-006856-b1w25ob5 1147 7 die die NN cord-006856-b1w25ob5 1147 8 IS be VBZ cord-006856-b1w25ob5 1147 9 blockieren blockieren NNP cord-006856-b1w25ob5 1147 10 . . . cord-006856-b1w25ob5 1148 1 Ein Ein NNP cord-006856-b1w25ob5 1148 2 ähnlicher ähnlicher NN cord-006856-b1w25ob5 1148 3 Effekt Effekt NNP cord-006856-b1w25ob5 1148 4 wurde wurde NN cord-006856-b1w25ob5 1148 5 für für IN cord-006856-b1w25ob5 1148 6 Kortikosteroide Kortikosteroide NNP cord-006856-b1w25ob5 1148 7 , , , cord-006856-b1w25ob5 1148 8 aber aber NNP cord-006856-b1w25ob5 1148 9 nicht nicht NNP cord-006856-b1w25ob5 1148 10 Mycophenolat Mycophenolat NNP cord-006856-b1w25ob5 1148 11 beobachtet beobachtet NNP cord-006856-b1w25ob5 1148 12 , , , cord-006856-b1w25ob5 1148 13 was be VBD cord-006856-b1w25ob5 1148 14 auf auf NNP cord-006856-b1w25ob5 1148 15 eine eine NNP cord-006856-b1w25ob5 1149 1 essentielle essentielle NNP cord-006856-b1w25ob5 1149 2 Rolle Rolle NNP cord-006856-b1w25ob5 1149 3 des des FW cord-006856-b1w25ob5 1149 4 Calcineurin Calcineurin NNP cord-006856-b1w25ob5 1149 5 - - HYPH cord-006856-b1w25ob5 1149 6 NF nf NN cord-006856-b1w25ob5 1149 7 - - HYPH cord-006856-b1w25ob5 1149 8 κB κB NNP cord-006856-b1w25ob5 1149 9 - - HYPH cord-006856-b1w25ob5 1149 10 Signalweges Signalweges NNP cord-006856-b1w25ob5 1149 11 für für RB cord-006856-b1w25ob5 1149 12 die die VBP cord-006856-b1w25ob5 1150 1 TCR TCR NNP cord-006856-b1w25ob5 1150 2 / / , cord-006856-b1w25ob5 1150 3 CD3-Regulation cd3-regulation NN cord-006856-b1w25ob5 1151 1 i -PRON- PRP cord-006856-b1w25ob5 1151 2 m be VBP cord-006856-b1w25ob5 1151 3 Rahmen Rahmen NNP cord-006856-b1w25ob5 1151 4 der der NNP cord-006856-b1w25ob5 1151 5 T T NNP cord-006856-b1w25ob5 1151 6 - - HYPH cord-006856-b1w25ob5 1151 7 Zellaktivierung Zellaktivierung NNP cord-006856-b1w25ob5 1151 8 hinweist hinweist NN cord-006856-b1w25ob5 1151 9 . . . cord-006856-b1w25ob5 1152 1 Interessanterweise Interessanterweise NNP cord-006856-b1w25ob5 1152 2 blockierte blockierte NNS cord-006856-b1w25ob5 1152 3 das das NNP cord-006856-b1w25ob5 1152 4 neue neue NNP cord-006856-b1w25ob5 1152 5 Immunsuppressivum Immunsuppressivum NNP cord-006856-b1w25ob5 1152 6 FK778 fk778 XX cord-006856-b1w25ob5 1153 1 nicht nicht NNP cord-006856-b1w25ob5 1153 2 nur nur NNP cord-006856-b1w25ob5 1153 3 die die VBP cord-006856-b1w25ob5 1154 1 TCR TCR NNP cord-006856-b1w25ob5 1154 2 / / SYM cord-006856-b1w25ob5 1154 3 CD3- CD3- NNP cord-006856-b1w25ob5 1154 4 , , , cord-006856-b1w25ob5 1154 5 sondern sondern NNP cord-006856-b1w25ob5 1154 6 auch auch NNP cord-006856-b1w25ob5 1154 7 die die VBP cord-006856-b1w25ob5 1154 8 LFA-1-und LFA-1-und NNP cord-006856-b1w25ob5 1154 9 F F NNP cord-006856-b1w25ob5 1154 10 - - HYPH cord-006856-b1w25ob5 1154 11 Aktin Aktin NNP cord-006856-b1w25ob5 1154 12 - - HYPH cord-006856-b1w25ob5 1154 13 Rekrutierung Rekrutierung NNP cord-006856-b1w25ob5 1154 14 in in IN cord-006856-b1w25ob5 1154 15 die die NN cord-006856-b1w25ob5 1154 16 IS be VBZ cord-006856-b1w25ob5 1154 17 . . . cord-006856-b1w25ob5 1155 1 Die die VB cord-006856-b1w25ob5 1156 1 Bedeutung Bedeutung NNP cord-006856-b1w25ob5 1156 2 dieser dieser NNP cord-006856-b1w25ob5 1156 3 globalen globalen NNP cord-006856-b1w25ob5 1156 4 Interferenz Interferenz NNP cord-006856-b1w25ob5 1156 5 mit mit NNP cord-006856-b1w25ob5 1156 6 der der NNP cord-006856-b1w25ob5 1157 1 IS be VBZ cord-006856-b1w25ob5 1157 2 - - : cord-006856-b1w25ob5 1157 3 Ausbildung Ausbildung NNP cord-006856-b1w25ob5 1157 4 für für IN cord-006856-b1w25ob5 1157 5 die die VBP cord-006856-b1w25ob5 1157 6 spezifische spezifische NN cord-006856-b1w25ob5 1157 7 Immunantwort Immunantwort NNP cord-006856-b1w25ob5 1157 8 muss muss NNP cord-006856-b1w25ob5 1157 9 in in IN cord-006856-b1w25ob5 1157 10 weiterführenden weiterführenden JJ cord-006856-b1w25ob5 1157 11 Studien Studien NNP cord-006856-b1w25ob5 1157 12 geklärt geklärt NNP cord-006856-b1w25ob5 1157 13 werden werden NNP cord-006856-b1w25ob5 1157 14 . . . cord-006856-b1w25ob5 1158 1 Diese Diese NNP cord-006856-b1w25ob5 1158 2 Daten Daten NNP cord-006856-b1w25ob5 1158 3 zeigen zeigen NNP cord-006856-b1w25ob5 1158 4 , , , cord-006856-b1w25ob5 1158 5 dass dass NNP cord-006856-b1w25ob5 1158 6 klassiche klassiche NNP cord-006856-b1w25ob5 1158 7 Immunsuppressiva Immunsuppressiva NNP cord-006856-b1w25ob5 1158 8 nicht nicht NNP cord-006856-b1w25ob5 1158 9 nur nur NNP cord-006856-b1w25ob5 1159 1 simple simple JJ cord-006856-b1w25ob5 1159 2 Blocker Blocker NNP cord-006856-b1w25ob5 1159 3 der der NNP cord-006856-b1w25ob5 1159 4 Zytokinsynthese Zytokinsynthese NNP cord-006856-b1w25ob5 1159 5 sind sind NNP cord-006856-b1w25ob5 1159 6 , , , cord-006856-b1w25ob5 1159 7 sondern sondern NNP cord-006856-b1w25ob5 1159 8 schon schon NNP cord-006856-b1w25ob5 1159 9 sehr sehr NNP cord-006856-b1w25ob5 1159 10 früh früh NNP cord-006856-b1w25ob5 1159 11 die die VBP cord-006856-b1w25ob5 1159 12 T T NNP cord-006856-b1w25ob5 1159 13 - - HYPH cord-006856-b1w25ob5 1159 14 Zell Zell NNP cord-006856-b1w25ob5 1159 15 - - HYPH cord-006856-b1w25ob5 1159 16 APZ- APZ- NNP cord-006856-b1w25ob5 1160 1 Interaktion Interaktion NNP cord-006856-b1w25ob5 1160 2 stören stören NNS cord-006856-b1w25ob5 1160 3 und und XX cord-006856-b1w25ob5 1161 1 damit damit NNP cord-006856-b1w25ob5 1161 2 einen einen NNP cord-006856-b1w25ob5 1161 3 weiteren weiteren NNP cord-006856-b1w25ob5 1161 4 immunologischen immunologischen NNP cord-006856-b1w25ob5 1161 5 Mechanismus Mechanismus NNP cord-006856-b1w25ob5 1161 6 besitzen besitzen VBD cord-006856-b1w25ob5 1161 7 , , , cord-006856-b1w25ob5 1161 8 der der NNP cord-006856-b1w25ob5 1161 9 ihre ihre NNP cord-006856-b1w25ob5 1161 10 klinische klinische NNP cord-006856-b1w25ob5 1161 11 Potenz Potenz NNP cord-006856-b1w25ob5 1161 12 erklärt erklärt NNP cord-006856-b1w25ob5 1161 13 . . . cord-006856-b1w25ob5 1162 1 Background background NN cord-006856-b1w25ob5 1162 2 . . . cord-006856-b1w25ob5 1163 1 Ischemia ischemia NN cord-006856-b1w25ob5 1163 2 ( ( -LRB- cord-006856-b1w25ob5 1163 3 I i NN cord-006856-b1w25ob5 1163 4 ) ) -RRB- cord-006856-b1w25ob5 1163 5 and and CC cord-006856-b1w25ob5 1163 6 reperfusion reperfusion NN cord-006856-b1w25ob5 1163 7 ( ( -LRB- cord-006856-b1w25ob5 1163 8 R r NN cord-006856-b1w25ob5 1163 9 ) ) -RRB- cord-006856-b1w25ob5 1163 10 trigger trigger VB cord-006856-b1w25ob5 1163 11 a a DT cord-006856-b1w25ob5 1163 12 series series NN cord-006856-b1w25ob5 1163 13 of of IN cord-006856-b1w25ob5 1163 14 events event NNS cord-006856-b1w25ob5 1163 15 , , , cord-006856-b1w25ob5 1163 16 which which WDT cord-006856-b1w25ob5 1163 17 culminate culminate VBP cord-006856-b1w25ob5 1163 18 in in IN cord-006856-b1w25ob5 1163 19 severe severe JJ cord-006856-b1w25ob5 1163 20 injuries injury NNS cord-006856-b1w25ob5 1163 21 to to IN cord-006856-b1w25ob5 1163 22 the the DT cord-006856-b1w25ob5 1163 23 affected affect VBN cord-006856-b1w25ob5 1163 24 organs organ NNS cord-006856-b1w25ob5 1163 25 in in IN cord-006856-b1w25ob5 1163 26 organ organ NN cord-006856-b1w25ob5 1163 27 transplantation transplantation NN cord-006856-b1w25ob5 1163 28 . . . cord-006856-b1w25ob5 1164 1 Cell cell NN cord-006856-b1w25ob5 1164 2 death death NN cord-006856-b1w25ob5 1164 3 , , , cord-006856-b1w25ob5 1164 4 metabolic metabolic JJ cord-006856-b1w25ob5 1164 5 alterations alteration NNS cord-006856-b1w25ob5 1164 6 , , , cord-006856-b1w25ob5 1164 7 and and CC cord-006856-b1w25ob5 1164 8 inflammation inflammation NN cord-006856-b1w25ob5 1164 9 result result NN cord-006856-b1w25ob5 1164 10 in in IN cord-006856-b1w25ob5 1164 11 impairment impairment NN cord-006856-b1w25ob5 1164 12 of of IN cord-006856-b1w25ob5 1164 13 shortand shortand JJ cord-006856-b1w25ob5 1164 14 long long JJ cord-006856-b1w25ob5 1164 15 - - HYPH cord-006856-b1w25ob5 1164 16 term term NN cord-006856-b1w25ob5 1164 17 function function NN cord-006856-b1w25ob5 1164 18 . . . cord-006856-b1w25ob5 1165 1 The the DT cord-006856-b1w25ob5 1165 2 group group NN cord-006856-b1w25ob5 1165 3 of of IN cord-006856-b1w25ob5 1165 4 mitogen mitogen NNP cord-006856-b1w25ob5 1165 5 - - HYPH cord-006856-b1w25ob5 1165 6 activated activate VBN cord-006856-b1w25ob5 1165 7 protein protein NN cord-006856-b1w25ob5 1165 8 kinases kinase NNS cord-006856-b1w25ob5 1165 9 ( ( -LRB- cord-006856-b1w25ob5 1165 10 MAPKs MAPKs NNP cord-006856-b1w25ob5 1165 11 ) ) -RRB- cord-006856-b1w25ob5 1165 12 are be VBP cord-006856-b1w25ob5 1165 13 central central JJ cord-006856-b1w25ob5 1165 14 regulators regulator NNS cord-006856-b1w25ob5 1165 15 of of IN cord-006856-b1w25ob5 1165 16 these these DT cord-006856-b1w25ob5 1165 17 events event NNS cord-006856-b1w25ob5 1165 18 , , , cord-006856-b1w25ob5 1165 19 they -PRON- PRP cord-006856-b1w25ob5 1165 20 have have VBP cord-006856-b1w25ob5 1165 21 been be VBN cord-006856-b1w25ob5 1165 22 implicated implicate VBN cord-006856-b1w25ob5 1165 23 through through IN cord-006856-b1w25ob5 1165 24 aberrant aberrant JJ cord-006856-b1w25ob5 1165 25 activation activation NN cord-006856-b1w25ob5 1165 26 in in IN cord-006856-b1w25ob5 1165 27 many many JJ cord-006856-b1w25ob5 1165 28 pathophysiological pathophysiological JJ cord-006856-b1w25ob5 1165 29 settings setting NNS cord-006856-b1w25ob5 1165 30 ranging range VBG cord-006856-b1w25ob5 1165 31 from from IN cord-006856-b1w25ob5 1165 32 autoimmune autoimmune JJ cord-006856-b1w25ob5 1165 33 diseases disease NNS cord-006856-b1w25ob5 1165 34 , , , cord-006856-b1w25ob5 1165 35 cancer cancer NN cord-006856-b1w25ob5 1165 36 , , , cord-006856-b1w25ob5 1165 37 to to IN cord-006856-b1w25ob5 1165 38 I i NN cord-006856-b1w25ob5 1165 39 / / SYM cord-006856-b1w25ob5 1165 40 R r NN cord-006856-b1w25ob5 1165 41 - - HYPH cord-006856-b1w25ob5 1165 42 associated associate VBN cord-006856-b1w25ob5 1165 43 organ organ NN cord-006856-b1w25ob5 1165 44 damage damage NN cord-006856-b1w25ob5 1165 45 . . . cord-006856-b1w25ob5 1166 1 Methods method NNS cord-006856-b1w25ob5 1166 2 . . . cord-006856-b1w25ob5 1167 1 Intracellular Intracellular NNP cord-006856-b1w25ob5 1167 2 signaling signal VBG cord-006856-b1w25ob5 1167 3 pathways pathway NNS cord-006856-b1w25ob5 1167 4 were be VBD cord-006856-b1w25ob5 1167 5 analysed analyse VBN cord-006856-b1w25ob5 1167 6 in in IN cord-006856-b1w25ob5 1167 7 vivo vivo NN cord-006856-b1w25ob5 1167 8 and and CC cord-006856-b1w25ob5 1167 9 in in IN cord-006856-b1w25ob5 1167 10 vitro vitro FW cord-006856-b1w25ob5 1167 11 employing employ VBG cord-006856-b1w25ob5 1167 12 a a DT cord-006856-b1w25ob5 1167 13 cardiomyocyte cardiomyocyte NNP cord-006856-b1w25ob5 1167 14 cell cell NN cord-006856-b1w25ob5 1167 15 line line NN cord-006856-b1w25ob5 1167 16 and and CC cord-006856-b1w25ob5 1167 17 a a DT cord-006856-b1w25ob5 1167 18 murine murine JJ cord-006856-b1w25ob5 1167 19 heart heart NN cord-006856-b1w25ob5 1167 20 transplant transplant NN cord-006856-b1w25ob5 1167 21 model model NN cord-006856-b1w25ob5 1167 22 . . . cord-006856-b1w25ob5 1168 1 HL-1 HL-1 NNP cord-006856-b1w25ob5 1169 1 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1169 2 are be VBP cord-006856-b1w25ob5 1169 3 a a DT cord-006856-b1w25ob5 1169 4 cardiac cardiac JJ cord-006856-b1w25ob5 1169 5 muscle muscle NN cord-006856-b1w25ob5 1169 6 cell cell NN cord-006856-b1w25ob5 1169 7 line line NN cord-006856-b1w25ob5 1169 8 derived derive VBN cord-006856-b1w25ob5 1169 9 from from IN cord-006856-b1w25ob5 1169 10 AT-1 AT-1 NNP cord-006856-b1w25ob5 1169 11 mouse mouse NN cord-006856-b1w25ob5 1169 12 atrial atrial JJ cord-006856-b1w25ob5 1169 13 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1169 14 . . . cord-006856-b1w25ob5 1170 1 Syngeneic syngeneic NN cord-006856-b1w25ob5 1170 2 cardiac cardiac JJ cord-006856-b1w25ob5 1170 3 transplants transplant NNS cord-006856-b1w25ob5 1170 4 were be VBD cord-006856-b1w25ob5 1170 5 carried carry VBN cord-006856-b1w25ob5 1170 6 out out RP cord-006856-b1w25ob5 1170 7 us us NNP cord-006856-b1w25ob5 1170 8 - - HYPH cord-006856-b1w25ob5 1170 9 ing e VBG cord-006856-b1w25ob5 1170 10 male male JJ cord-006856-b1w25ob5 1170 11 inbred inbred JJ cord-006856-b1w25ob5 1170 12 BALB BALB NNP cord-006856-b1w25ob5 1170 13 / / SYM cord-006856-b1w25ob5 1170 14 c c NN cord-006856-b1w25ob5 1170 15 mice mouse NNS cord-006856-b1w25ob5 1170 16 , , , cord-006856-b1w25ob5 1170 17 hearts heart NNS cord-006856-b1w25ob5 1170 18 were be VBD cord-006856-b1w25ob5 1170 19 transplanted transplant VBN cord-006856-b1w25ob5 1170 20 heterotopically heterotopically RB cord-006856-b1w25ob5 1170 21 into into IN cord-006856-b1w25ob5 1170 22 the the DT cord-006856-b1w25ob5 1170 23 neck neck NN cord-006856-b1w25ob5 1170 24 of of IN cord-006856-b1w25ob5 1170 25 recipients recipient NNS cord-006856-b1w25ob5 1170 26 . . . cord-006856-b1w25ob5 1171 1 Results result NNS cord-006856-b1w25ob5 1171 2 . . . cord-006856-b1w25ob5 1172 1 In in IN cord-006856-b1w25ob5 1172 2 summary summary NN cord-006856-b1w25ob5 1172 3 , , , cord-006856-b1w25ob5 1172 4 ( ( -LRB- cord-006856-b1w25ob5 1172 5 i i NN cord-006856-b1w25ob5 1172 6 ) ) -RRB- cord-006856-b1w25ob5 1172 7 reoxygenation reoxygenation NNP cord-006856-b1w25ob5 1172 8 was be VBD cord-006856-b1w25ob5 1172 9 characterized characterize VBN cord-006856-b1w25ob5 1172 10 by by IN cord-006856-b1w25ob5 1172 11 a a DT cord-006856-b1w25ob5 1172 12 dramatic dramatic JJ cord-006856-b1w25ob5 1172 13 increase increase NN cord-006856-b1w25ob5 1172 14 in in IN cord-006856-b1w25ob5 1172 15 the the DT cord-006856-b1w25ob5 1172 16 activity activity NN cord-006856-b1w25ob5 1172 17 of of IN cord-006856-b1w25ob5 1172 18 all all DT cord-006856-b1w25ob5 1172 19 MAPKs mapk NNS cord-006856-b1w25ob5 1172 20 at at IN cord-006856-b1w25ob5 1172 21 the the DT cord-006856-b1w25ob5 1172 22 end end NN cord-006856-b1w25ob5 1172 23 of of IN cord-006856-b1w25ob5 1172 24 the the DT cord-006856-b1w25ob5 1172 25 observation observation NN cord-006856-b1w25ob5 1172 26 period period NN cord-006856-b1w25ob5 1172 27 ; ; , cord-006856-b1w25ob5 1172 28 ( ( -LRB- cord-006856-b1w25ob5 1172 29 ii ii NN cord-006856-b1w25ob5 1172 30 ) ) -RRB- cord-006856-b1w25ob5 1172 31 growth growth NN cord-006856-b1w25ob5 1172 32 factor factor NN cord-006856-b1w25ob5 1172 33 abrogation abrogation NN cord-006856-b1w25ob5 1172 34 together together RB cord-006856-b1w25ob5 1172 35 with with IN cord-006856-b1w25ob5 1172 36 hypoxia hypoxia NN cord-006856-b1w25ob5 1172 37 ( ( -LRB- cord-006856-b1w25ob5 1172 38 H h NN cord-006856-b1w25ob5 1172 39 ) ) -RRB- cord-006856-b1w25ob5 1172 40 and and CC cord-006856-b1w25ob5 1172 41 reoxygenation reoxygenation NN cord-006856-b1w25ob5 1172 42 ( ( -LRB- cord-006856-b1w25ob5 1172 43 R r NN cord-006856-b1w25ob5 1172 44 ) ) -RRB- cord-006856-b1w25ob5 1172 45 had have VBD cord-006856-b1w25ob5 1172 46 a a DT cord-006856-b1w25ob5 1172 47 substantial substantial JJ cord-006856-b1w25ob5 1172 48 effect effect NN cord-006856-b1w25ob5 1172 49 on on IN cord-006856-b1w25ob5 1172 50 the the DT cord-006856-b1w25ob5 1172 51 course course NN cord-006856-b1w25ob5 1172 52 of of IN cord-006856-b1w25ob5 1172 53 signaling signal VBG cord-006856-b1w25ob5 1172 54 events event NNS cord-006856-b1w25ob5 1172 55 ; ; , cord-006856-b1w25ob5 1172 56 ( ( -LRB- cord-006856-b1w25ob5 1172 57 iii iii NN cord-006856-b1w25ob5 1172 58 ) ) -RRB- cord-006856-b1w25ob5 1172 59 signaling signal VBG cord-006856-b1w25ob5 1172 60 processes process NNS cord-006856-b1w25ob5 1172 61 in in IN cord-006856-b1w25ob5 1172 62 response response NN cord-006856-b1w25ob5 1172 63 to to IN cord-006856-b1w25ob5 1172 64 ischemia ischemia NN cord-006856-b1w25ob5 1172 65 and and CC cord-006856-b1w25ob5 1172 66 reperfusion reperfusion NN cord-006856-b1w25ob5 1172 67 in in IN cord-006856-b1w25ob5 1172 68 vivo vivo NN cord-006856-b1w25ob5 1172 69 are be VBP cord-006856-b1w25ob5 1172 70 in in IN cord-006856-b1w25ob5 1172 71 line line NN cord-006856-b1w25ob5 1172 72 with with IN cord-006856-b1w25ob5 1172 73 observations observation NNS cord-006856-b1w25ob5 1172 74 made make VBN cord-006856-b1w25ob5 1172 75 in in IN cord-006856-b1w25ob5 1172 76 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1172 77 . . . cord-006856-b1w25ob5 1173 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1173 2 . . . cord-006856-b1w25ob5 1174 1 Data datum NNS cord-006856-b1w25ob5 1174 2 obtained obtain VBN cord-006856-b1w25ob5 1174 3 so so RB cord-006856-b1w25ob5 1174 4 far far RB cord-006856-b1w25ob5 1174 5 in in IN cord-006856-b1w25ob5 1174 6 our -PRON- PRP$ cord-006856-b1w25ob5 1174 7 study study NN cord-006856-b1w25ob5 1174 8 demonstrate demonstrate VBP cord-006856-b1w25ob5 1174 9 the the DT cord-006856-b1w25ob5 1174 10 suitability suitability NN cord-006856-b1w25ob5 1174 11 of of IN cord-006856-b1w25ob5 1174 12 the the DT cord-006856-b1w25ob5 1174 13 chosen choose VBN cord-006856-b1w25ob5 1174 14 experimental experimental JJ cord-006856-b1w25ob5 1174 15 approaches approach NNS cord-006856-b1w25ob5 1174 16 for for IN cord-006856-b1w25ob5 1174 17 investigation investigation NN cord-006856-b1w25ob5 1174 18 of of IN cord-006856-b1w25ob5 1174 19 I I NNP cord-006856-b1w25ob5 1174 20 / / SYM cord-006856-b1w25ob5 1174 21 R r NN cord-006856-b1w25ob5 1174 22 - - HYPH cord-006856-b1w25ob5 1174 23 associated associate VBN cord-006856-b1w25ob5 1174 24 alterations alteration NNS cord-006856-b1w25ob5 1174 25 in in IN cord-006856-b1w25ob5 1174 26 intracellular intracellular JJ cord-006856-b1w25ob5 1174 27 signaling signaling NN cord-006856-b1w25ob5 1174 28 and and CC cord-006856-b1w25ob5 1174 29 cellular cellular JJ cord-006856-b1w25ob5 1174 30 responses response NNS cord-006856-b1w25ob5 1174 31 . . . cord-006856-b1w25ob5 1175 1 Preliminary preliminary JJ cord-006856-b1w25ob5 1175 2 data datum NNS cord-006856-b1w25ob5 1175 3 suggest suggest VBP cord-006856-b1w25ob5 1175 4 that that IN cord-006856-b1w25ob5 1175 5 H h NN cord-006856-b1w25ob5 1175 6 / / SYM cord-006856-b1w25ob5 1175 7 R r NN cord-006856-b1w25ob5 1175 8 treatment treatment NN cord-006856-b1w25ob5 1175 9 of of IN cord-006856-b1w25ob5 1175 10 HL-1 HL-1 NNP cord-006856-b1w25ob5 1175 11 results result VBZ cord-006856-b1w25ob5 1175 12 in in IN cord-006856-b1w25ob5 1175 13 significant significant JJ cord-006856-b1w25ob5 1175 14 apoptotic apoptotic JJ cord-006856-b1w25ob5 1175 15 cell cell NN cord-006856-b1w25ob5 1175 16 death death NN cord-006856-b1w25ob5 1175 17 , , , cord-006856-b1w25ob5 1175 18 the the DT cord-006856-b1w25ob5 1175 19 intracellular intracellular JJ cord-006856-b1w25ob5 1175 20 signaling signal VBG cord-006856-b1w25ob5 1175 21 pathways pathway NNS cord-006856-b1w25ob5 1175 22 involved involve VBN cord-006856-b1w25ob5 1175 23 are be VBP cord-006856-b1w25ob5 1175 24 therefore therefore RB cord-006856-b1w25ob5 1175 25 currently currently RB cord-006856-b1w25ob5 1175 26 analyzed analyze VBN cord-006856-b1w25ob5 1175 27 . . . cord-006856-b1w25ob5 1176 1 Background background NN cord-006856-b1w25ob5 1176 2 . . . cord-006856-b1w25ob5 1177 1 Ischemia ischemia NN cord-006856-b1w25ob5 1177 2 and and CC cord-006856-b1w25ob5 1177 3 reperfusion reperfusion NN cord-006856-b1w25ob5 1177 4 ( ( -LRB- cord-006856-b1w25ob5 1177 5 I i NN cord-006856-b1w25ob5 1177 6 / / SYM cord-006856-b1w25ob5 1177 7 R r NN cord-006856-b1w25ob5 1177 8 ) ) -RRB- cord-006856-b1w25ob5 1177 9 in in IN cord-006856-b1w25ob5 1177 10 cardiac cardiac JJ cord-006856-b1w25ob5 1177 11 transplantation transplantation NN cord-006856-b1w25ob5 1177 12 results result NNS cord-006856-b1w25ob5 1177 13 in in IN cord-006856-b1w25ob5 1177 14 inflammation inflammation NN cord-006856-b1w25ob5 1177 15 and and CC cord-006856-b1w25ob5 1177 16 cell cell NN cord-006856-b1w25ob5 1177 17 death death NN cord-006856-b1w25ob5 1177 18 . . . cord-006856-b1w25ob5 1178 1 To to TO cord-006856-b1w25ob5 1178 2 gain gain VB cord-006856-b1w25ob5 1178 3 further further JJ cord-006856-b1w25ob5 1178 4 insight insight NN cord-006856-b1w25ob5 1178 5 into into IN cord-006856-b1w25ob5 1178 6 the the DT cord-006856-b1w25ob5 1178 7 regulation regulation NN cord-006856-b1w25ob5 1178 8 of of IN cord-006856-b1w25ob5 1178 9 these these DT cord-006856-b1w25ob5 1178 10 processes process NNS cord-006856-b1w25ob5 1178 11 , , , cord-006856-b1w25ob5 1178 12 we -PRON- PRP cord-006856-b1w25ob5 1178 13 investigated investigate VBD cord-006856-b1w25ob5 1178 14 the the DT cord-006856-b1w25ob5 1178 15 role role NN cord-006856-b1w25ob5 1178 16 of of IN cord-006856-b1w25ob5 1178 17 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1178 18 ( ( -LRB- cord-006856-b1w25ob5 1178 19 24p3 24p3 CD cord-006856-b1w25ob5 1178 20 , , , cord-006856-b1w25ob5 1178 21 NGAL NGAL NNP cord-006856-b1w25ob5 1178 22 , , , cord-006856-b1w25ob5 1178 23 uterocalin uterocalin NNP cord-006856-b1w25ob5 1178 24 ) ) -RRB- cord-006856-b1w25ob5 1178 25 , , , cord-006856-b1w25ob5 1178 26 a a DT cord-006856-b1w25ob5 1178 27 potential potential JJ cord-006856-b1w25ob5 1178 28 regulator regulator NN cord-006856-b1w25ob5 1178 29 of of IN cord-006856-b1w25ob5 1178 30 the the DT cord-006856-b1w25ob5 1178 31 acute acute JJ cord-006856-b1w25ob5 1178 32 inflammatory inflammatory JJ cord-006856-b1w25ob5 1178 33 response response NN cord-006856-b1w25ob5 1178 34 and and CC cord-006856-b1w25ob5 1178 35 cellular cellular JJ cord-006856-b1w25ob5 1178 36 apoptosis apoptosis NN cord-006856-b1w25ob5 1178 37 in in IN cord-006856-b1w25ob5 1178 38 vitro vitro FW cord-006856-b1w25ob5 1178 39 and and CC cord-006856-b1w25ob5 1178 40 in in IN cord-006856-b1w25ob5 1178 41 vivo vivo NNP cord-006856-b1w25ob5 1178 42 . . . cord-006856-b1w25ob5 1179 1 Methods method NNS cord-006856-b1w25ob5 1179 2 . . . cord-006856-b1w25ob5 1180 1 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1180 2 hearts heart NNS cord-006856-b1w25ob5 1180 3 were be VBD cord-006856-b1w25ob5 1180 4 heterotopically heterotopically RB cord-006856-b1w25ob5 1180 5 transplanted transplant VBN cord-006856-b1w25ob5 1180 6 to to IN cord-006856-b1w25ob5 1180 7 syngeneic syngeneic NNS cord-006856-b1w25ob5 1180 8 recipients recipient NNS cord-006856-b1w25ob5 1180 9 immediately immediately RB cord-006856-b1w25ob5 1180 10 and and CC cord-006856-b1w25ob5 1180 11 after after IN cord-006856-b1w25ob5 1180 12 10 10 CD cord-006856-b1w25ob5 1180 13 hours hour NNS cord-006856-b1w25ob5 1180 14 of of IN cord-006856-b1w25ob5 1180 15 prolonged prolonged JJ cord-006856-b1w25ob5 1180 16 cold cold JJ cord-006856-b1w25ob5 1180 17 ischemia ischemia NN cord-006856-b1w25ob5 1180 18 with with IN cord-006856-b1w25ob5 1180 19 the the DT cord-006856-b1w25ob5 1180 20 grafts graft NNS cord-006856-b1w25ob5 1180 21 harvested harvest VBN cord-006856-b1w25ob5 1180 22 at at IN cord-006856-b1w25ob5 1180 23 various various JJ cord-006856-b1w25ob5 1180 24 timepoints timepoint NNS cord-006856-b1w25ob5 1180 25 ( ( -LRB- cord-006856-b1w25ob5 1180 26 2 2 CD cord-006856-b1w25ob5 1180 27 min min NNP cord-006856-b1w25ob5 1180 28 , , , cord-006856-b1w25ob5 1180 29 2 2 CD cord-006856-b1w25ob5 1180 30 h h NN cord-006856-b1w25ob5 1180 31 , , , cord-006856-b1w25ob5 1180 32 12 12 CD cord-006856-b1w25ob5 1180 33 h h NN cord-006856-b1w25ob5 1180 34 , , , cord-006856-b1w25ob5 1180 35 24 24 CD cord-006856-b1w25ob5 1180 36 h h NN cord-006856-b1w25ob5 1180 37 , , , cord-006856-b1w25ob5 1180 38 48 48 CD cord-006856-b1w25ob5 1180 39 h h NN cord-006856-b1w25ob5 1180 40 , , , cord-006856-b1w25ob5 1180 41 10 10 CD cord-006856-b1w25ob5 1180 42 d d NN cord-006856-b1w25ob5 1180 43 ) ) -RRB- cord-006856-b1w25ob5 1180 44 after after IN cord-006856-b1w25ob5 1180 45 transplantation transplantation NN cord-006856-b1w25ob5 1180 46 . . . cord-006856-b1w25ob5 1181 1 Gene gene NN cord-006856-b1w25ob5 1181 2 expression expression NN cord-006856-b1w25ob5 1181 3 analysis analysis NN cord-006856-b1w25ob5 1181 4 on on IN cord-006856-b1w25ob5 1181 5 mRNA mRNA NNP cord-006856-b1w25ob5 1181 6 extracts extract NNS cord-006856-b1w25ob5 1181 7 was be VBD cord-006856-b1w25ob5 1181 8 performed perform VBN cord-006856-b1w25ob5 1181 9 employing employ VBG cord-006856-b1w25ob5 1181 10 cDNA cdna NN cord-006856-b1w25ob5 1181 11 microarray microarray NN cord-006856-b1w25ob5 1181 12 and and CC cord-006856-b1w25ob5 1181 13 RT RT NNP cord-006856-b1w25ob5 1181 14 - - HYPH cord-006856-b1w25ob5 1181 15 PCR PCR NNP cord-006856-b1w25ob5 1181 16 . . . cord-006856-b1w25ob5 1182 1 Protein protein NN cord-006856-b1w25ob5 1182 2 synthesis synthesis NN cord-006856-b1w25ob5 1182 3 was be VBD cord-006856-b1w25ob5 1182 4 investigated investigate VBN cord-006856-b1w25ob5 1182 5 by by IN cord-006856-b1w25ob5 1182 6 Western western JJ cord-006856-b1w25ob5 1182 7 blotting blotting NN cord-006856-b1w25ob5 1182 8 and and CC cord-006856-b1w25ob5 1182 9 apoptosis apoptosis NN cord-006856-b1w25ob5 1182 10 by by IN cord-006856-b1w25ob5 1182 11 using use VBG cord-006856-b1w25ob5 1182 12 TUNEL TUNEL NNP cord-006856-b1w25ob5 1182 13 assay assay NN cord-006856-b1w25ob5 1182 14 . . . cord-006856-b1w25ob5 1183 1 For for IN cord-006856-b1w25ob5 1183 2 the the DT cord-006856-b1w25ob5 1183 3 identification identification NN cord-006856-b1w25ob5 1183 4 of of IN cord-006856-b1w25ob5 1183 5 the the DT cord-006856-b1w25ob5 1183 6 cellular cellular JJ cord-006856-b1w25ob5 1183 7 source source NN cord-006856-b1w25ob5 1183 8 of of IN cord-006856-b1w25ob5 1183 9 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1183 10 and and CC cord-006856-b1w25ob5 1183 11 its -PRON- PRP$ cord-006856-b1w25ob5 1183 12 function function NN cord-006856-b1w25ob5 1183 13 in in IN cord-006856-b1w25ob5 1183 14 I I NNP cord-006856-b1w25ob5 1183 15 / / SYM cord-006856-b1w25ob5 1183 16 R r NN cord-006856-b1w25ob5 1183 17 - - HYPH cord-006856-b1w25ob5 1183 18 associated associated JJ cord-006856-b1w25ob5 1183 19 cell cell NN cord-006856-b1w25ob5 1183 20 death death NN cord-006856-b1w25ob5 1183 21 , , , cord-006856-b1w25ob5 1183 22 the the DT cord-006856-b1w25ob5 1183 23 effect effect NN cord-006856-b1w25ob5 1183 24 of of IN cord-006856-b1w25ob5 1183 25 recombinant recombinant JJ cord-006856-b1w25ob5 1183 26 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1183 27 was be VBD cord-006856-b1w25ob5 1183 28 investigated investigate VBN cord-006856-b1w25ob5 1183 29 in in IN cord-006856-b1w25ob5 1183 30 the the DT cord-006856-b1w25ob5 1183 31 HL-1 HL-1 NNP cord-006856-b1w25ob5 1183 32 cardiomyocyte cardiomyocyte NNP cord-006856-b1w25ob5 1183 33 cell cell NN cord-006856-b1w25ob5 1183 34 line line NN cord-006856-b1w25ob5 1183 35 . . . cord-006856-b1w25ob5 1184 1 HL-1 HL-1 NNP cord-006856-b1w25ob5 1185 1 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1185 2 undergoing undergo VBG cord-006856-b1w25ob5 1185 3 ischemia ischemia NN cord-006856-b1w25ob5 1185 4 / / SYM cord-006856-b1w25ob5 1185 5 reoxygenation reoxygenation NN cord-006856-b1w25ob5 1185 6 as as RB cord-006856-b1w25ob5 1185 7 well well RB cord-006856-b1w25ob5 1185 8 as as IN cord-006856-b1w25ob5 1185 9 purified purify VBN cord-006856-b1w25ob5 1185 10 mononuclear mononuclear JJ cord-006856-b1w25ob5 1185 11 cells cell NNS cord-006856-b1w25ob5 1185 12 and and CC cord-006856-b1w25ob5 1185 13 granulocytes granulocyte NNS cord-006856-b1w25ob5 1185 14 were be VBD cord-006856-b1w25ob5 1185 15 analyzed analyze VBN cord-006856-b1w25ob5 1185 16 for for IN cord-006856-b1w25ob5 1185 17 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1185 18 expression expression NN cord-006856-b1w25ob5 1185 19 by by IN cord-006856-b1w25ob5 1185 20 RT RT NNP cord-006856-b1w25ob5 1185 21 - - HYPH cord-006856-b1w25ob5 1185 22 PCR PCR NNP cord-006856-b1w25ob5 1185 23 . . . cord-006856-b1w25ob5 1186 1 Results result NNS cord-006856-b1w25ob5 1186 2 . . . cord-006856-b1w25ob5 1187 1 In in IN cord-006856-b1w25ob5 1187 2 the the DT cord-006856-b1w25ob5 1187 3 cardiac cardiac JJ cord-006856-b1w25ob5 1187 4 transplants transplant NNS cord-006856-b1w25ob5 1187 5 , , , cord-006856-b1w25ob5 1187 6 high high JJ cord-006856-b1w25ob5 1187 7 levels level NNS cord-006856-b1w25ob5 1187 8 of of IN cord-006856-b1w25ob5 1187 9 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1187 10 gene gene NN cord-006856-b1w25ob5 1187 11 and and CC cord-006856-b1w25ob5 1187 12 protein protein NN cord-006856-b1w25ob5 1187 13 expression expression NN cord-006856-b1w25ob5 1187 14 were be VBD cord-006856-b1w25ob5 1187 15 detected detect VBN cord-006856-b1w25ob5 1187 16 at at IN cord-006856-b1w25ob5 1187 17 12 12 CD cord-006856-b1w25ob5 1187 18 h h NN cord-006856-b1w25ob5 1187 19 of of IN cord-006856-b1w25ob5 1187 20 reperfusion reperfusion NN cord-006856-b1w25ob5 1187 21 , , , cord-006856-b1w25ob5 1187 22 whereby whereby WRB cord-006856-b1w25ob5 1187 23 transcription transcription NN cord-006856-b1w25ob5 1187 24 was be VBD cord-006856-b1w25ob5 1187 25 higher high JJR cord-006856-b1w25ob5 1187 26 in in IN cord-006856-b1w25ob5 1187 27 groups group NNS cord-006856-b1w25ob5 1187 28 without without IN cord-006856-b1w25ob5 1187 29 cold cold JJ cord-006856-b1w25ob5 1187 30 ischemia ischemia NN cord-006856-b1w25ob5 1187 31 ( ( -LRB- cord-006856-b1w25ob5 1187 32 22-versus 22-versus CD cord-006856-b1w25ob5 1187 33 8.8-fold 8.8-fold CD cord-006856-b1w25ob5 1187 34 ) ) -RRB- cord-006856-b1w25ob5 1187 35 . . . cord-006856-b1w25ob5 1188 1 HE he PRP cord-006856-b1w25ob5 1188 2 staining stain VBG cord-006856-b1w25ob5 1188 3 demonstrated demonstrate VBD cord-006856-b1w25ob5 1188 4 dense dense JJ cord-006856-b1w25ob5 1188 5 mononuclear mononuclear NN cord-006856-b1w25ob5 1188 6 infiltrates infiltrate VBZ cord-006856-b1w25ob5 1188 7 , , , cord-006856-b1w25ob5 1188 8 cellular cellular JJ cord-006856-b1w25ob5 1188 9 edema edema NN cord-006856-b1w25ob5 1188 10 , , , cord-006856-b1w25ob5 1188 11 and and CC cord-006856-b1w25ob5 1188 12 small small JJ cord-006856-b1w25ob5 1188 13 focal focal JJ cord-006856-b1w25ob5 1188 14 necrosis necrosis NN cord-006856-b1w25ob5 1188 15 in in IN cord-006856-b1w25ob5 1188 16 groups group NNS cord-006856-b1w25ob5 1188 17 with with IN cord-006856-b1w25ob5 1188 18 and and CC cord-006856-b1w25ob5 1188 19 without without IN cord-006856-b1w25ob5 1188 20 prolonged prolong VBN cord-006856-b1w25ob5 1188 21 cold cold JJ cord-006856-b1w25ob5 1188 22 ischemia ischemia NN cord-006856-b1w25ob5 1188 23 . . . cord-006856-b1w25ob5 1189 1 Upregulation Upregulation NNP cord-006856-b1w25ob5 1189 2 of of IN cord-006856-b1w25ob5 1189 3 gene gene NN cord-006856-b1w25ob5 1189 4 transcription transcription NN cord-006856-b1w25ob5 1189 5 was be VBD cord-006856-b1w25ob5 1189 6 confirmed confirm VBN cord-006856-b1w25ob5 1189 7 by by IN cord-006856-b1w25ob5 1189 8 PCR PCR NNP cord-006856-b1w25ob5 1189 9 . . . cord-006856-b1w25ob5 1190 1 Apoptotic apoptotic JJ cord-006856-b1w25ob5 1190 2 cells cell NNS cord-006856-b1w25ob5 1190 3 were be VBD cord-006856-b1w25ob5 1190 4 first first RB cord-006856-b1w25ob5 1190 5 detectable detectable JJ cord-006856-b1w25ob5 1190 6 at at IN cord-006856-b1w25ob5 1190 7 day day NN cord-006856-b1w25ob5 1190 8 2 2 CD cord-006856-b1w25ob5 1190 9 and and CC cord-006856-b1w25ob5 1190 10 peaked peak VBD cord-006856-b1w25ob5 1190 11 10 10 CD cord-006856-b1w25ob5 1190 12 days day NNS cord-006856-b1w25ob5 1190 13 after after IN cord-006856-b1w25ob5 1190 14 transplantation transplantation NN cord-006856-b1w25ob5 1190 15 . . . cord-006856-b1w25ob5 1191 1 Expression expression NN cord-006856-b1w25ob5 1191 2 of of IN cord-006856-b1w25ob5 1191 3 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1191 4 was be VBD cord-006856-b1w25ob5 1191 5 also also RB cord-006856-b1w25ob5 1191 6 detected detect VBN cord-006856-b1w25ob5 1191 7 in in IN cord-006856-b1w25ob5 1191 8 HL-1 HL-1 NNP cord-006856-b1w25ob5 1191 9 cells cell NNS cord-006856-b1w25ob5 1191 10 by by IN cord-006856-b1w25ob5 1191 11 RT RT NNP cord-006856-b1w25ob5 1191 12 - - HYPH cord-006856-b1w25ob5 1191 13 PCR PCR NNP cord-006856-b1w25ob5 1191 14 and and CC cord-006856-b1w25ob5 1191 15 Western western JJ cord-006856-b1w25ob5 1191 16 blotting blotting NN cord-006856-b1w25ob5 1191 17 following follow VBG cord-006856-b1w25ob5 1191 18 I I NNP cord-006856-b1w25ob5 1191 19 / / SYM cord-006856-b1w25ob5 1191 20 R r NN cord-006856-b1w25ob5 1191 21 , , , cord-006856-b1w25ob5 1191 22 demonstrating demonstrate VBG cord-006856-b1w25ob5 1191 23 for for IN cord-006856-b1w25ob5 1191 24 the the DT cord-006856-b1w25ob5 1191 25 first first JJ cord-006856-b1w25ob5 1191 26 time time NN cord-006856-b1w25ob5 1191 27 the the DT cord-006856-b1w25ob5 1191 28 presence presence NN cord-006856-b1w25ob5 1191 29 of of IN cord-006856-b1w25ob5 1191 30 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1191 31 in in IN cord-006856-b1w25ob5 1191 32 this this DT cord-006856-b1w25ob5 1191 33 cell cell NN cord-006856-b1w25ob5 1191 34 lineage lineage NN cord-006856-b1w25ob5 1191 35 . . . cord-006856-b1w25ob5 1192 1 Lipocalin-2-transfected Lipocalin-2-transfected NNP cord-006856-b1w25ob5 1192 2 HL-1 HL-1 NNP cord-006856-b1w25ob5 1193 1 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1193 2 showed show VBD cord-006856-b1w25ob5 1193 3 a a DT cord-006856-b1w25ob5 1193 4 higher high JJR cord-006856-b1w25ob5 1193 5 cell cell NN cord-006856-b1w25ob5 1193 6 viability viability NN cord-006856-b1w25ob5 1193 7 especially especially RB cord-006856-b1w25ob5 1193 8 under under IN cord-006856-b1w25ob5 1193 9 ischemic ischemic JJ cord-006856-b1w25ob5 1193 10 condition condition NN cord-006856-b1w25ob5 1193 11 . . . cord-006856-b1w25ob5 1194 1 Megalin megalin RB cord-006856-b1w25ob5 1194 2 , , , cord-006856-b1w25ob5 1194 3 known know VBN cord-006856-b1w25ob5 1194 4 as as IN cord-006856-b1w25ob5 1194 5 the the DT cord-006856-b1w25ob5 1194 6 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1194 7 receptor receptor NN cord-006856-b1w25ob5 1194 8 , , , cord-006856-b1w25ob5 1194 9 was be VBD cord-006856-b1w25ob5 1194 10 detected detect VBN cord-006856-b1w25ob5 1194 11 in in IN cord-006856-b1w25ob5 1194 12 HL-1 HL-1 NNP cord-006856-b1w25ob5 1194 13 cells cell NNS cord-006856-b1w25ob5 1194 14 by by IN cord-006856-b1w25ob5 1194 15 RT RT NNP cord-006856-b1w25ob5 1194 16 - - HYPH cord-006856-b1w25ob5 1194 17 PCR PCR NNP cord-006856-b1w25ob5 1194 18 . . . cord-006856-b1w25ob5 1195 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1195 2 . . . cord-006856-b1w25ob5 1196 1 This this DT cord-006856-b1w25ob5 1196 2 study study NN cord-006856-b1w25ob5 1196 3 demonstrates demonstrate VBZ cord-006856-b1w25ob5 1196 4 the the DT cord-006856-b1w25ob5 1196 5 time time NN cord-006856-b1w25ob5 1196 6 - - HYPH cord-006856-b1w25ob5 1196 7 dependent dependent JJ cord-006856-b1w25ob5 1196 8 expression expression NN cord-006856-b1w25ob5 1196 9 of of IN cord-006856-b1w25ob5 1196 10 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1196 11 in in IN cord-006856-b1w25ob5 1196 12 a a DT cord-006856-b1w25ob5 1196 13 cardiomyocyte cardiomyocyte JJ cord-006856-b1w25ob5 1196 14 culture culture NN cord-006856-b1w25ob5 1196 15 as as RB cord-006856-b1w25ob5 1196 16 well well RB cord-006856-b1w25ob5 1196 17 as as IN cord-006856-b1w25ob5 1196 18 in in IN cord-006856-b1w25ob5 1196 19 transplanted transplant VBN cord-006856-b1w25ob5 1196 20 hearts heart NNS cord-006856-b1w25ob5 1196 21 in in IN cord-006856-b1w25ob5 1196 22 response response NN cord-006856-b1w25ob5 1196 23 to to IN cord-006856-b1w25ob5 1196 24 ischemia ischemia NN cord-006856-b1w25ob5 1196 25 and and CC cord-006856-b1w25ob5 1196 26 reperfusion reperfusion NN cord-006856-b1w25ob5 1196 27 / / SYM cord-006856-b1w25ob5 1196 28 reoxygenation reoxygenation NN cord-006856-b1w25ob5 1196 29 . . . cord-006856-b1w25ob5 1197 1 Lipocalin-2 Lipocalin-2 NNP cord-006856-b1w25ob5 1197 2 is be VBZ cord-006856-b1w25ob5 1197 3 suggested suggest VBN cord-006856-b1w25ob5 1197 4 to to TO cord-006856-b1w25ob5 1197 5 target target VB cord-006856-b1w25ob5 1197 6 cardiomyocytes cardiomyocyte NNS cord-006856-b1w25ob5 1197 7 with with IN cord-006856-b1w25ob5 1197 8 ameliorating ameliorate VBG cord-006856-b1w25ob5 1197 9 effects effect NNS cord-006856-b1w25ob5 1197 10 on on IN cord-006856-b1w25ob5 1197 11 cell cell NN cord-006856-b1w25ob5 1197 12 viability viability NN cord-006856-b1w25ob5 1197 13 during during IN cord-006856-b1w25ob5 1197 14 ischemia ischemia NN cord-006856-b1w25ob5 1197 15 . . . cord-006856-b1w25ob5 1198 1 Obvious obvious JJ cord-006856-b1w25ob5 1198 2 alterations alteration NNS cord-006856-b1w25ob5 1198 3 in in IN cord-006856-b1w25ob5 1198 4 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1198 5 expression expression NN cord-006856-b1w25ob5 1198 6 at at IN cord-006856-b1w25ob5 1198 7 the the DT cord-006856-b1w25ob5 1198 8 protein protein NN cord-006856-b1w25ob5 1198 9 level level NN cord-006856-b1w25ob5 1198 10 suggest suggest VBP cord-006856-b1w25ob5 1198 11 a a DT cord-006856-b1w25ob5 1198 12 possible possible JJ cord-006856-b1w25ob5 1198 13 involvement involvement NN cord-006856-b1w25ob5 1198 14 of of IN cord-006856-b1w25ob5 1198 15 lipocalin-2 lipocalin-2 NNP cord-006856-b1w25ob5 1198 16 during during IN cord-006856-b1w25ob5 1198 17 I I NNP cord-006856-b1w25ob5 1198 18 / / SYM cord-006856-b1w25ob5 1198 19 R r NN cord-006856-b1w25ob5 1198 20 - - HYPH cord-006856-b1w25ob5 1198 21 induced induce VBN cord-006856-b1w25ob5 1198 22 cell cell NN cord-006856-b1w25ob5 1198 23 death death NN cord-006856-b1w25ob5 1198 24 probably probably RB cord-006856-b1w25ob5 1198 25 as as IN cord-006856-b1w25ob5 1198 26 a a DT cord-006856-b1w25ob5 1198 27 self self NN cord-006856-b1w25ob5 1198 28 - - HYPH cord-006856-b1w25ob5 1198 29 limiting limit VBG cord-006856-b1w25ob5 1198 30 process process NN cord-006856-b1w25ob5 1198 31 for for IN cord-006856-b1w25ob5 1198 32 inflammation inflammation NN cord-006856-b1w25ob5 1198 33 . . . cord-006856-b1w25ob5 1199 1 Background background NN cord-006856-b1w25ob5 1199 2 . . . cord-006856-b1w25ob5 1200 1 Protease protease NN cord-006856-b1w25ob5 1200 2 activation activation NN cord-006856-b1w25ob5 1200 3 as as RB cord-006856-b1w25ob5 1200 4 well well RB cord-006856-b1w25ob5 1200 5 as as IN cord-006856-b1w25ob5 1200 6 inflammatory inflammatory JJ cord-006856-b1w25ob5 1200 7 responses response NNS cord-006856-b1w25ob5 1200 8 contribute contribute VBP cord-006856-b1w25ob5 1200 9 to to IN cord-006856-b1w25ob5 1200 10 organ organ NN cord-006856-b1w25ob5 1200 11 damage damage NN cord-006856-b1w25ob5 1200 12 in in IN cord-006856-b1w25ob5 1200 13 response response NN cord-006856-b1w25ob5 1200 14 to to IN cord-006856-b1w25ob5 1200 15 ischemia ischemia NN cord-006856-b1w25ob5 1200 16 and and CC cord-006856-b1w25ob5 1200 17 reperfusion reperfusion NN cord-006856-b1w25ob5 1200 18 . . . cord-006856-b1w25ob5 1201 1 In in IN cord-006856-b1w25ob5 1201 2 this this DT cord-006856-b1w25ob5 1201 3 study study NN cord-006856-b1w25ob5 1201 4 we -PRON- PRP cord-006856-b1w25ob5 1201 5 investigated investigate VBD cord-006856-b1w25ob5 1201 6 the the DT cord-006856-b1w25ob5 1201 7 role role NN cord-006856-b1w25ob5 1201 8 of of IN cord-006856-b1w25ob5 1201 9 the the DT cord-006856-b1w25ob5 1201 10 protease protease NN cord-006856-b1w25ob5 1201 11 inhibitor inhibitor NN cord-006856-b1w25ob5 1201 12 SLPI SLPI NNP cord-006856-b1w25ob5 1201 13 in in IN cord-006856-b1w25ob5 1201 14 ischemia ischemia NN cord-006856-b1w25ob5 1201 15 and and CC cord-006856-b1w25ob5 1201 16 cardiac cardiac JJ cord-006856-b1w25ob5 1201 17 transplantation transplantation NN cord-006856-b1w25ob5 1201 18 . . . cord-006856-b1w25ob5 1202 1 Methods method NNS cord-006856-b1w25ob5 1202 2 . . . cord-006856-b1w25ob5 1203 1 Hearts heart NNS cord-006856-b1w25ob5 1203 2 from from IN cord-006856-b1w25ob5 1203 3 SLPI SLPI NNP cord-006856-b1w25ob5 1203 4 knockout knockout NN cord-006856-b1w25ob5 1203 5 mice mouse NNS cord-006856-b1w25ob5 1203 6 ( ( -LRB- cord-006856-b1w25ob5 1203 7 SLPI-/- SLPI-/- NNP cord-006856-b1w25ob5 1203 8 ) ) -RRB- cord-006856-b1w25ob5 1203 9 were be VBD cord-006856-b1w25ob5 1203 10 heterotopically heterotopically RB cord-006856-b1w25ob5 1203 11 transplanted transplant VBN cord-006856-b1w25ob5 1203 12 to to IN cord-006856-b1w25ob5 1203 13 SLPI-/-recipients slpi-/-recipient NNS cord-006856-b1w25ob5 1203 14 . . . cord-006856-b1w25ob5 1204 1 Grafts graft NNS cord-006856-b1w25ob5 1204 2 underwent undergo VBD cord-006856-b1w25ob5 1204 3 10 10 CD cord-006856-b1w25ob5 1204 4 hours hour NNS cord-006856-b1w25ob5 1204 5 of of IN cord-006856-b1w25ob5 1204 6 cold cold JJ cord-006856-b1w25ob5 1204 7 ischemia ischemia NN cord-006856-b1w25ob5 1204 8 ( ( -LRB- cord-006856-b1w25ob5 1204 9 CI CI NNP cord-006856-b1w25ob5 1204 10 ) ) -RRB- cord-006856-b1w25ob5 1204 11 prior prior RB cord-006856-b1w25ob5 1204 12 to to IN cord-006856-b1w25ob5 1204 13 transplantation transplantation NN cord-006856-b1w25ob5 1204 14 or or CC cord-006856-b1w25ob5 1204 15 were be VBD cord-006856-b1w25ob5 1204 16 transplanted transplant VBN cord-006856-b1w25ob5 1204 17 immediately immediately RB cord-006856-b1w25ob5 1204 18 . . . cord-006856-b1w25ob5 1205 1 C57Bl/6 C57Bl/6 JJR cord-006856-b1w25ob5 1205 2 wild wild JJ cord-006856-b1w25ob5 1205 3 - - HYPH cord-006856-b1w25ob5 1205 4 type type NN cord-006856-b1w25ob5 1205 5 isografts isograft NNS cord-006856-b1w25ob5 1205 6 ( ( -LRB- cord-006856-b1w25ob5 1205 7 WT WT NNP cord-006856-b1w25ob5 1205 8 ) ) -RRB- cord-006856-b1w25ob5 1206 1 undergoing undergo VBG cord-006856-b1w25ob5 1206 2 the the DT cord-006856-b1w25ob5 1206 3 same same JJ cord-006856-b1w25ob5 1206 4 procedure procedure NN cord-006856-b1w25ob5 1206 5 served serve VBD cord-006856-b1w25ob5 1206 6 as as IN cord-006856-b1w25ob5 1206 7 controls control NNS cord-006856-b1w25ob5 1206 8 . . . cord-006856-b1w25ob5 1207 1 In in IN cord-006856-b1w25ob5 1207 2 selected select VBN cord-006856-b1w25ob5 1207 3 groups group NNS cord-006856-b1w25ob5 1207 4 , , , cord-006856-b1w25ob5 1207 5 200 200 CD cord-006856-b1w25ob5 1207 6 µg µg NN cord-006856-b1w25ob5 1207 7 of of IN cord-006856-b1w25ob5 1207 8 recombinant recombinant JJ cord-006856-b1w25ob5 1207 9 SLPI SLPI NNP cord-006856-b1w25ob5 1207 10 ( ( -LRB- cord-006856-b1w25ob5 1207 11 rSLPI rSLPI NNP cord-006856-b1w25ob5 1207 12 ) ) -RRB- cord-006856-b1w25ob5 1207 13 were be VBD cord-006856-b1w25ob5 1207 14 added add VBN cord-006856-b1w25ob5 1207 15 to to IN cord-006856-b1w25ob5 1207 16 the the DT cord-006856-b1w25ob5 1207 17 preservation preservation NN cord-006856-b1w25ob5 1207 18 solution solution NN cord-006856-b1w25ob5 1207 19 or or CC cord-006856-b1w25ob5 1207 20 given give VBN cord-006856-b1w25ob5 1207 21 i.v i.v NNP cord-006856-b1w25ob5 1207 22 . . . cord-006856-b1w25ob5 1208 1 after after IN cord-006856-b1w25ob5 1208 2 reperfusion reperfusion NN cord-006856-b1w25ob5 1208 3 . . . cord-006856-b1w25ob5 1209 1 After after IN cord-006856-b1w25ob5 1209 2 evaluation evaluation NN cord-006856-b1w25ob5 1209 3 of of IN cord-006856-b1w25ob5 1209 4 graft graft NN cord-006856-b1w25ob5 1209 5 function function NN cord-006856-b1w25ob5 1209 6 , , , cord-006856-b1w25ob5 1209 7 hearts heart NNS cord-006856-b1w25ob5 1209 8 were be VBD cord-006856-b1w25ob5 1209 9 removed remove VBN cord-006856-b1w25ob5 1209 10 at at IN cord-006856-b1w25ob5 1209 11 15 15 CD cord-006856-b1w25ob5 1209 12 min min NN cord-006856-b1w25ob5 1209 13 , , , cord-006856-b1w25ob5 1209 14 12 12 CD cord-006856-b1w25ob5 1209 15 h h NN cord-006856-b1w25ob5 1209 16 , , , cord-006856-b1w25ob5 1209 17 24 24 CD cord-006856-b1w25ob5 1209 18 h h NN cord-006856-b1w25ob5 1209 19 , , , cord-006856-b1w25ob5 1209 20 and and CC cord-006856-b1w25ob5 1209 21 10 10 CD cord-006856-b1w25ob5 1209 22 days day NNS cord-006856-b1w25ob5 1209 23 . . . cord-006856-b1w25ob5 1210 1 Morphology morphology NN cord-006856-b1w25ob5 1210 2 was be VBD cord-006856-b1w25ob5 1210 3 investigated investigate VBN cord-006856-b1w25ob5 1210 4 by by IN cord-006856-b1w25ob5 1210 5 histology histology NN cord-006856-b1w25ob5 1210 6 , , , cord-006856-b1w25ob5 1210 7 SLPI SLPI NNP cord-006856-b1w25ob5 1210 8 gene gene NN cord-006856-b1w25ob5 1210 9 expression expression NN cord-006856-b1w25ob5 1210 10 was be VBD cord-006856-b1w25ob5 1210 11 analysed analyse VBN cord-006856-b1w25ob5 1210 12 using use VBG cord-006856-b1w25ob5 1210 13 quantitative quantitative JJ cord-006856-b1w25ob5 1210 14 RT RT NNP cord-006856-b1w25ob5 1210 15 - - HYPH cord-006856-b1w25ob5 1210 16 PCR PCR NNP cord-006856-b1w25ob5 1210 17 . . . cord-006856-b1w25ob5 1211 1 SLPI SLPI NNP cord-006856-b1w25ob5 1211 2 protein protein NN cord-006856-b1w25ob5 1211 3 expression expression NN cord-006856-b1w25ob5 1211 4 was be VBD cord-006856-b1w25ob5 1211 5 studied study VBN cord-006856-b1w25ob5 1211 6 by by IN cord-006856-b1w25ob5 1211 7 immunohistochemistry immunohistochemistry FW cord-006856-b1w25ob5 1211 8 ( ( -LRB- cord-006856-b1w25ob5 1211 9 IHC IHC NNP cord-006856-b1w25ob5 1211 10 ) ) -RRB- cord-006856-b1w25ob5 1211 11 . . . cord-006856-b1w25ob5 1212 1 SLPI SLPI NNP cord-006856-b1w25ob5 1212 2 , , , cord-006856-b1w25ob5 1212 3 TNF TNF NNP cord-006856-b1w25ob5 1212 4 - - HYPH cord-006856-b1w25ob5 1212 5 α α NNP cord-006856-b1w25ob5 1212 6 , , , cord-006856-b1w25ob5 1212 7 TGF TGF NNP cord-006856-b1w25ob5 1212 8 - - HYPH cord-006856-b1w25ob5 1212 9 β β NNP cord-006856-b1w25ob5 1212 10 , , , cord-006856-b1w25ob5 1212 11 and and CC cord-006856-b1w25ob5 1212 12 NF NF NNP cord-006856-b1w25ob5 1212 13 - - HYPH cord-006856-b1w25ob5 1212 14 κB κB NNP cord-006856-b1w25ob5 1212 15 , , , cord-006856-b1w25ob5 1212 16 Cathepsin Cathepsin NNP cord-006856-b1w25ob5 1212 17 G G NNP cord-006856-b1w25ob5 1212 18 , , , cord-006856-b1w25ob5 1212 19 and and CC cord-006856-b1w25ob5 1212 20 Elastase Elastase NNP cord-006856-b1w25ob5 1212 21 activity activity NN cord-006856-b1w25ob5 1212 22 were be VBD cord-006856-b1w25ob5 1212 23 analysed analyse VBN cord-006856-b1w25ob5 1212 24 employing employ VBG cord-006856-b1w25ob5 1212 25 ELISA ELISA NNP cord-006856-b1w25ob5 1212 26 and and CC cord-006856-b1w25ob5 1212 27 Western western JJ cord-006856-b1w25ob5 1212 28 blot blot NN cord-006856-b1w25ob5 1212 29 . . . cord-006856-b1w25ob5 1213 1 Results result NNS cord-006856-b1w25ob5 1213 2 . . . cord-006856-b1w25ob5 1214 1 At at IN cord-006856-b1w25ob5 1214 2 15 15 CD cord-006856-b1w25ob5 1214 3 min min NN cord-006856-b1w25ob5 1214 4 , , , cord-006856-b1w25ob5 1214 5 recovery recovery NN cord-006856-b1w25ob5 1214 6 of of IN cord-006856-b1w25ob5 1214 7 graft graft NN cord-006856-b1w25ob5 1214 8 function function NN cord-006856-b1w25ob5 1214 9 was be VBD cord-006856-b1w25ob5 1214 10 normal normal JJ cord-006856-b1w25ob5 1214 11 in in IN cord-006856-b1w25ob5 1214 12 WT WT NNP cord-006856-b1w25ob5 1215 1 and and CC cord-006856-b1w25ob5 1215 2 SLPI-/-mice SLPI-/-mice NNP cord-006856-b1w25ob5 1215 3 transplanted transplant VBD cord-006856-b1w25ob5 1215 4 without without IN cord-006856-b1w25ob5 1215 5 CI CI NNP cord-006856-b1w25ob5 1215 6 ( ( -LRB- cord-006856-b1w25ob5 1215 7 4.0 4.0 CD cord-006856-b1w25ob5 1215 8 ± ± NNP cord-006856-b1w25ob5 1215 9 0.0 0.0 CD cord-006856-b1w25ob5 1215 10 ) ) -RRB- cord-006856-b1w25ob5 1215 11 . . . cord-006856-b1w25ob5 1216 1 In in IN cord-006856-b1w25ob5 1216 2 contrast contrast NN cord-006856-b1w25ob5 1216 3 , , , cord-006856-b1w25ob5 1216 4 SLPI-/-hearts slpi-/-hearts CD cord-006856-b1w25ob5 1216 5 transplanted transplant VBN cord-006856-b1w25ob5 1216 6 after after IN cord-006856-b1w25ob5 1216 7 10 10 CD cord-006856-b1w25ob5 1216 8 h h NN cord-006856-b1w25ob5 1216 9 of of IN cord-006856-b1w25ob5 1216 10 CI CI NNP cord-006856-b1w25ob5 1216 11 showed show VBD cord-006856-b1w25ob5 1216 12 no no DT cord-006856-b1w25ob5 1216 13 or or CC cord-006856-b1w25ob5 1216 14 marginal marginal JJ cord-006856-b1w25ob5 1216 15 recovery recovery NN cord-006856-b1w25ob5 1216 16 of of IN cord-006856-b1w25ob5 1216 17 organ organ NN cord-006856-b1w25ob5 1216 18 function function NN cord-006856-b1w25ob5 1216 19 ( ( -LRB- cord-006856-b1w25ob5 1216 20 0.6 0.6 CD cord-006856-b1w25ob5 1216 21 ± ± CD cord-006856-b1w25ob5 1216 22 0.65 0.65 CD cord-006856-b1w25ob5 1216 23 ) ) -RRB- cord-006856-b1w25ob5 1216 24 . . . cord-006856-b1w25ob5 1217 1 At at IN cord-006856-b1w25ob5 1217 2 24 24 CD cord-006856-b1w25ob5 1217 3 h h NN cord-006856-b1w25ob5 1217 4 , , , cord-006856-b1w25ob5 1217 5 cardiac cardiac JJ cord-006856-b1w25ob5 1217 6 function function NN cord-006856-b1w25ob5 1217 7 in in IN cord-006856-b1w25ob5 1217 8 SLPI-/-(2.8 SLPI-/-(2.8 NNP cord-006856-b1w25ob5 1217 9 ± ± NNP cord-006856-b1w25ob5 1217 10 0.89 0.89 CD cord-006856-b1w25ob5 1217 11 ) ) -RRB- cord-006856-b1w25ob5 1217 12 was be VBD cord-006856-b1w25ob5 1217 13 less less JJR cord-006856-b1w25ob5 1217 14 when when WRB cord-006856-b1w25ob5 1217 15 compared compare VBN cord-006856-b1w25ob5 1217 16 with with IN cord-006856-b1w25ob5 1217 17 WT WT NNP cord-006856-b1w25ob5 1217 18 ( ( -LRB- cord-006856-b1w25ob5 1217 19 3.36 3.36 CD cord-006856-b1w25ob5 1217 20 ± ± CD cord-006856-b1w25ob5 1217 21 0.55 0.55 CD cord-006856-b1w25ob5 1217 22 ) ) -RRB- cord-006856-b1w25ob5 1217 23 . . . cord-006856-b1w25ob5 1218 1 Single single JJ cord-006856-b1w25ob5 1218 2 administration administration NN cord-006856-b1w25ob5 1218 3 of of IN cord-006856-b1w25ob5 1218 4 rSLPI rSLPI NNP cord-006856-b1w25ob5 1218 5 i.v i.v NNP cord-006856-b1w25ob5 1218 6 . . NNP cord-006856-b1w25ob5 1218 7 had have VBD cord-006856-b1w25ob5 1218 8 no no DT cord-006856-b1w25ob5 1218 9 effect effect NN cord-006856-b1w25ob5 1218 10 ; ; : cord-006856-b1w25ob5 1218 11 however however RB cord-006856-b1w25ob5 1218 12 , , , cord-006856-b1w25ob5 1218 13 when when WRB cord-006856-b1w25ob5 1218 14 SLPI SLPI NNP cord-006856-b1w25ob5 1218 15 was be VBD cord-006856-b1w25ob5 1218 16 added add VBN cord-006856-b1w25ob5 1218 17 to to IN cord-006856-b1w25ob5 1218 18 the the DT cord-006856-b1w25ob5 1218 19 preservation preservation NN cord-006856-b1w25ob5 1218 20 solution solution NN cord-006856-b1w25ob5 1218 21 , , , cord-006856-b1w25ob5 1218 22 organ organ NN cord-006856-b1w25ob5 1218 23 function function NN cord-006856-b1w25ob5 1218 24 comparable comparable JJ cord-006856-b1w25ob5 1218 25 to to IN cord-006856-b1w25ob5 1218 26 WT WT NNP cord-006856-b1w25ob5 1218 27 mice mouse NNS cord-006856-b1w25ob5 1218 28 was be VBD cord-006856-b1w25ob5 1218 29 observed observe VBN cord-006856-b1w25ob5 1218 30 ( ( -LRB- cord-006856-b1w25ob5 1218 31 3.36 3.36 CD cord-006856-b1w25ob5 1218 32 ± ± CD cord-006856-b1w25ob5 1218 33 0.55 0.55 CD cord-006856-b1w25ob5 1218 34 ) ) -RRB- cord-006856-b1w25ob5 1218 35 . . . cord-006856-b1w25ob5 1219 1 A a DT cord-006856-b1w25ob5 1219 2 mild mild JJ cord-006856-b1w25ob5 1219 3 mononuclear mononuclear JJ cord-006856-b1w25ob5 1219 4 cell cell NN cord-006856-b1w25ob5 1219 5 infiltrate infiltrate NN cord-006856-b1w25ob5 1219 6 and and CC cord-006856-b1w25ob5 1219 7 small small JJ cord-006856-b1w25ob5 1219 8 focal focal JJ cord-006856-b1w25ob5 1219 9 necrosis necrosis NN cord-006856-b1w25ob5 1219 10 where where WRB cord-006856-b1w25ob5 1219 11 found find VBN cord-006856-b1w25ob5 1219 12 in in IN cord-006856-b1w25ob5 1219 13 all all DT cord-006856-b1w25ob5 1219 14 groups group NNS cord-006856-b1w25ob5 1219 15 at at IN cord-006856-b1w25ob5 1219 16 24 24 CD cord-006856-b1w25ob5 1219 17 h. h. NN cord-006856-b1w25ob5 1220 1 At at IN cord-006856-b1w25ob5 1220 2 10 10 CD cord-006856-b1w25ob5 1220 3 days day NNS cord-006856-b1w25ob5 1220 4 , , , cord-006856-b1w25ob5 1220 5 postischemic postischemic JJ cord-006856-b1w25ob5 1220 6 inflammation inflammation NN cord-006856-b1w25ob5 1220 7 as as RB cord-006856-b1w25ob5 1220 8 well well RB cord-006856-b1w25ob5 1220 9 as as IN cord-006856-b1w25ob5 1220 10 myocyte myocyte NNP cord-006856-b1w25ob5 1220 11 necrosis necrosis NN cord-006856-b1w25ob5 1220 12 were be VBD cord-006856-b1w25ob5 1220 13 significantly significantly RB cord-006856-b1w25ob5 1220 14 higher high JJR cord-006856-b1w25ob5 1220 15 in in IN cord-006856-b1w25ob5 1221 1 the the DT cord-006856-b1w25ob5 1221 2 SLPI-/group SLPI-/group NNP cord-006856-b1w25ob5 1221 3 ( ( -LRB- cord-006856-b1w25ob5 1221 4 2.5 2.5 CD cord-006856-b1w25ob5 1221 5 ± ± CD cord-006856-b1w25ob5 1221 6 0.5 0.5 CD cord-006856-b1w25ob5 1221 7 vs. vs. IN cord-006856-b1w25ob5 1221 8 1.8 1.8 CD cord-006856-b1w25ob5 1221 9 ± ± CD cord-006856-b1w25ob5 1221 10 0.4 0.4 CD cord-006856-b1w25ob5 1221 11 and and CC cord-006856-b1w25ob5 1221 12 1.6 1.6 CD cord-006856-b1w25ob5 1221 13 ± ± CD cord-006856-b1w25ob5 1221 14 0.5 0.5 CD cord-006856-b1w25ob5 1221 15 vs. vs. CC cord-006856-b1w25ob5 1221 16 0.2 0.2 CD cord-006856-b1w25ob5 1221 17 ± ± CD cord-006856-b1w25ob5 1221 18 0.4 0.4 CD cord-006856-b1w25ob5 1221 19 ) ) -RRB- cord-006856-b1w25ob5 1221 20 . . . cord-006856-b1w25ob5 1222 1 Myocyte Myocyte NNP cord-006856-b1w25ob5 1222 2 vacuolisation vacuolisation NN cord-006856-b1w25ob5 1222 3 as as IN cord-006856-b1w25ob5 1222 4 a a DT cord-006856-b1w25ob5 1222 5 sign sign NN cord-006856-b1w25ob5 1222 6 of of IN cord-006856-b1w25ob5 1222 7 sublethal sublethal JJ cord-006856-b1w25ob5 1222 8 ischemic ischemic JJ cord-006856-b1w25ob5 1222 9 injury injury NN cord-006856-b1w25ob5 1222 10 was be VBD cord-006856-b1w25ob5 1222 11 present present JJ cord-006856-b1w25ob5 1222 12 at at IN cord-006856-b1w25ob5 1222 13 high high JJ cord-006856-b1w25ob5 1222 14 level level NN cord-006856-b1w25ob5 1222 15 in in IN cord-006856-b1w25ob5 1222 16 SLPI-/-mice SLPI-/-mice NNP cord-006856-b1w25ob5 1222 17 undergoing undergo VBG cord-006856-b1w25ob5 1222 18 CI CI NNP cord-006856-b1w25ob5 1222 19 only only RB cord-006856-b1w25ob5 1222 20 . . . cord-006856-b1w25ob5 1223 1 SLPI SLPI NNP cord-006856-b1w25ob5 1223 2 gene gene NN cord-006856-b1w25ob5 1223 3 expression expression NN cord-006856-b1w25ob5 1223 4 was be VBD cord-006856-b1w25ob5 1223 5 detected detect VBN cord-006856-b1w25ob5 1223 6 in in IN cord-006856-b1w25ob5 1223 7 WT WT NNP cord-006856-b1w25ob5 1223 8 mice mouse NNS cord-006856-b1w25ob5 1223 9 at at IN cord-006856-b1w25ob5 1223 10 12 12 CD cord-006856-b1w25ob5 1223 11 and and CC cord-006856-b1w25ob5 1223 12 24 24 CD cord-006856-b1w25ob5 1223 13 h h NN cord-006856-b1w25ob5 1223 14 after after IN cord-006856-b1w25ob5 1223 15 reperfusion reperfusion NN cord-006856-b1w25ob5 1223 16 . . . cord-006856-b1w25ob5 1224 1 Gene gene NN cord-006856-b1w25ob5 1224 2 transcription transcription NN cord-006856-b1w25ob5 1224 3 at at IN cord-006856-b1w25ob5 1224 4 12 12 CD cord-006856-b1w25ob5 1224 5 h h NN cord-006856-b1w25ob5 1224 6 was be VBD cord-006856-b1w25ob5 1224 7 significantly significantly RB cord-006856-b1w25ob5 1224 8 higher high JJR cord-006856-b1w25ob5 1224 9 after after IN cord-006856-b1w25ob5 1224 10 prolonged prolong VBN cord-006856-b1w25ob5 1224 11 CI CI NNP cord-006856-b1w25ob5 1224 12 ( ( -LRB- cord-006856-b1w25ob5 1224 13 7.99 7.99 CD cord-006856-b1w25ob5 1224 14 vs. vs. CC cord-006856-b1w25ob5 1224 15 1.57 1.57 CD cord-006856-b1w25ob5 1224 16 orders order NNS cord-006856-b1w25ob5 1224 17 of of IN cord-006856-b1w25ob5 1224 18 magnitude magnitude NN cord-006856-b1w25ob5 1224 19 ) ) -RRB- cord-006856-b1w25ob5 1224 20 and and CC cord-006856-b1w25ob5 1224 21 was be VBD cord-006856-b1w25ob5 1224 22 associated associate VBN cord-006856-b1w25ob5 1224 23 with with IN cord-006856-b1w25ob5 1224 24 significantly significantly RB cord-006856-b1w25ob5 1224 25 decreased decrease VBN cord-006856-b1w25ob5 1224 26 NF NF NNP cord-006856-b1w25ob5 1224 27 - - HYPH cord-006856-b1w25ob5 1224 28 κB κB NNP cord-006856-b1w25ob5 1224 29 , , , cord-006856-b1w25ob5 1224 30 TGFβ TGFβ NNP cord-006856-b1w25ob5 1224 31 , , , cord-006856-b1w25ob5 1224 32 and and CC cord-006856-b1w25ob5 1224 33 TNF TNF NNP cord-006856-b1w25ob5 1224 34 - - HYPH cord-006856-b1w25ob5 1224 35 α α NNP cord-006856-b1w25ob5 1224 36 activity activity NN cord-006856-b1w25ob5 1224 37 . . . cord-006856-b1w25ob5 1225 1 SLPI SLPI NNP cord-006856-b1w25ob5 1225 2 protein protein NN cord-006856-b1w25ob5 1225 3 was be VBD cord-006856-b1w25ob5 1225 4 first first RB cord-006856-b1w25ob5 1225 5 observed observe VBN cord-006856-b1w25ob5 1225 6 at at IN cord-006856-b1w25ob5 1225 7 24 24 CD cord-006856-b1w25ob5 1225 8 h h NN cord-006856-b1w25ob5 1225 9 , , , cord-006856-b1w25ob5 1225 10 high high JJ cord-006856-b1w25ob5 1225 11 levels level NNS cord-006856-b1w25ob5 1225 12 of of IN cord-006856-b1w25ob5 1225 13 SLPI SLPI NNP cord-006856-b1w25ob5 1225 14 protein protein NN cord-006856-b1w25ob5 1225 15 were be VBD cord-006856-b1w25ob5 1225 16 found find VBN cord-006856-b1w25ob5 1225 17 at at IN cord-006856-b1w25ob5 1225 18 10 10 CD cord-006856-b1w25ob5 1225 19 days day NNS cord-006856-b1w25ob5 1225 20 . . . cord-006856-b1w25ob5 1226 1 SLPI SLPI NNP cord-006856-b1w25ob5 1226 2 - - HYPH cord-006856-b1w25ob5 1226 3 positive positive JJ cord-006856-b1w25ob5 1226 4 cells cell NNS cord-006856-b1w25ob5 1226 5 were be VBD cord-006856-b1w25ob5 1226 6 mainly mainly RB cord-006856-b1w25ob5 1226 7 identified identify VBN cord-006856-b1w25ob5 1226 8 as as IN cord-006856-b1w25ob5 1226 9 macrophages macrophage NNS cord-006856-b1w25ob5 1226 10 ( ( -LRB- cord-006856-b1w25ob5 1226 11 IHC IHC NNP cord-006856-b1w25ob5 1226 12 ) ) -RRB- cord-006856-b1w25ob5 1226 13 . . . cord-006856-b1w25ob5 1227 1 High high JJ cord-006856-b1w25ob5 1227 2 intragraft intragraft NN cord-006856-b1w25ob5 1227 3 levels level NNS cord-006856-b1w25ob5 1227 4 of of IN cord-006856-b1w25ob5 1227 5 SLPI SLPI NNP cord-006856-b1w25ob5 1227 6 activity activity NN cord-006856-b1w25ob5 1227 7 were be VBD cord-006856-b1w25ob5 1227 8 found find VBN cord-006856-b1w25ob5 1227 9 early early RB cord-006856-b1w25ob5 1227 10 as as RB cord-006856-b1w25ob5 1227 11 well well RB cord-006856-b1w25ob5 1227 12 as as IN cord-006856-b1w25ob5 1227 13 10 10 CD cord-006856-b1w25ob5 1227 14 days day NNS cord-006856-b1w25ob5 1227 15 after after IN cord-006856-b1w25ob5 1227 16 application application NN cord-006856-b1w25ob5 1227 17 of of IN cord-006856-b1w25ob5 1227 18 recombinant recombinant JJ cord-006856-b1w25ob5 1227 19 protein protein NN cord-006856-b1w25ob5 1227 20 . . . cord-006856-b1w25ob5 1228 1 High high JJ cord-006856-b1w25ob5 1228 2 SLPI SLPI NNP cord-006856-b1w25ob5 1228 3 levels level NNS cord-006856-b1w25ob5 1228 4 correlate correlate VBP cord-006856-b1w25ob5 1228 5 with with IN cord-006856-b1w25ob5 1228 6 decreased decrease VBN cord-006856-b1w25ob5 1228 7 Cathepsin Cathepsin NNP cord-006856-b1w25ob5 1228 8 G G NNP cord-006856-b1w25ob5 1228 9 early early RB cord-006856-b1w25ob5 1228 10 and and CC cord-006856-b1w25ob5 1228 11 decreased decrease VBD cord-006856-b1w25ob5 1228 12 NF nf NN cord-006856-b1w25ob5 1228 13 - - HYPH cord-006856-b1w25ob5 1228 14 κB κB NNP cord-006856-b1w25ob5 1228 15 , , , cord-006856-b1w25ob5 1228 16 TGF TGF NNP cord-006856-b1w25ob5 1228 17 - - HYPH cord-006856-b1w25ob5 1228 18 β β NNP cord-006856-b1w25ob5 1228 19 , , , cord-006856-b1w25ob5 1228 20 and and CC cord-006856-b1w25ob5 1228 21 elastase elastase NN cord-006856-b1w25ob5 1228 22 activity activity NN cord-006856-b1w25ob5 1228 23 late late RB cord-006856-b1w25ob5 1228 24 after after IN cord-006856-b1w25ob5 1228 25 reperfusion reperfusion NN cord-006856-b1w25ob5 1228 26 . . . cord-006856-b1w25ob5 1229 1 Conclusion conclusion NN cord-006856-b1w25ob5 1229 2 . . . cord-006856-b1w25ob5 1230 1 Herein herein RB cord-006856-b1w25ob5 1230 2 we -PRON- PRP cord-006856-b1w25ob5 1230 3 demonstrate demonstrate VBP cord-006856-b1w25ob5 1230 4 that that IN cord-006856-b1w25ob5 1230 5 SLPI SLPI NNP cord-006856-b1w25ob5 1230 6 has have VBZ cord-006856-b1w25ob5 1230 7 a a DT cord-006856-b1w25ob5 1230 8 substantial substantial JJ cord-006856-b1w25ob5 1230 9 effect effect NN cord-006856-b1w25ob5 1230 10 in in IN cord-006856-b1w25ob5 1230 11 prevention prevention NN cord-006856-b1w25ob5 1230 12 of of IN cord-006856-b1w25ob5 1230 13 inflammation inflammation NN cord-006856-b1w25ob5 1230 14 and and CC cord-006856-b1w25ob5 1230 15 myocyte myocyte NN cord-006856-b1w25ob5 1230 16 damage damage NN cord-006856-b1w25ob5 1230 17 in in IN cord-006856-b1w25ob5 1230 18 response response NN cord-006856-b1w25ob5 1230 19 to to IN cord-006856-b1w25ob5 1230 20 ischemia ischemia NN cord-006856-b1w25ob5 1230 21 and and CC cord-006856-b1w25ob5 1230 22 reperfusion reperfusion NN cord-006856-b1w25ob5 1230 23 of of IN cord-006856-b1w25ob5 1230 24 the the DT cord-006856-b1w25ob5 1230 25 heart heart NN cord-006856-b1w25ob5 1230 26 via via IN cord-006856-b1w25ob5 1230 27 inhibition inhibition NN cord-006856-b1w25ob5 1230 28 of of IN cord-006856-b1w25ob5 1230 29 NF nf NN cord-006856-b1w25ob5 1230 30 - - HYPH cord-006856-b1w25ob5 1230 31 κB κB NNP cord-006856-b1w25ob5 1230 32 , , , cord-006856-b1w25ob5 1230 33 TGF TGF NNP cord-006856-b1w25ob5 1230 34 - - HYPH cord-006856-b1w25ob5 1230 35 β β NNP cord-006856-b1w25ob5 1230 36 , , , cord-006856-b1w25ob5 1230 37 and and CC cord-006856-b1w25ob5 1230 38 elastase elastase NN cord-006856-b1w25ob5 1230 39 . . . cord-006856-b1w25ob5 1231 1 In in IN cord-006856-b1w25ob5 1231 2 addition addition NN cord-006856-b1w25ob5 1231 3 , , , cord-006856-b1w25ob5 1231 4 SLPI SLPI NNP cord-006856-b1w25ob5 1231 5 seems seem VBZ cord-006856-b1w25ob5 1231 6 to to TO cord-006856-b1w25ob5 1231 7 be be VB cord-006856-b1w25ob5 1231 8 crucial crucial JJ cord-006856-b1w25ob5 1231 9 for for IN cord-006856-b1w25ob5 1231 10 recovery recovery NN cord-006856-b1w25ob5 1231 11 of of IN cord-006856-b1w25ob5 1231 12 organ organ NN cord-006856-b1w25ob5 1231 13 function function NN cord-006856-b1w25ob5 1231 14 early early RB cord-006856-b1w25ob5 1231 15 after after IN cord-006856-b1w25ob5 1231 16 heart heart NN cord-006856-b1w25ob5 1231 17 transplantation transplantation NN cord-006856-b1w25ob5 1232 1 -inhibition -inhibition : cord-006856-b1w25ob5 1232 2 of of IN cord-006856-b1w25ob5 1232 3 protease protease NN cord-006856-b1w25ob5 1232 4 activity activity NN cord-006856-b1w25ob5 1232 5 seems seem VBZ cord-006856-b1w25ob5 1232 6 to to TO cord-006856-b1w25ob5 1232 7 be be VB cord-006856-b1w25ob5 1232 8 the the DT cord-006856-b1w25ob5 1232 9 underlying underlying JJ cord-006856-b1w25ob5 1232 10 mechanism mechanism NN cord-006856-b1w25ob5 1232 11 . . . cord-006856-b1w25ob5 1233 1 Perfusion perfusion NN cord-006856-b1w25ob5 1233 2 with with IN cord-006856-b1w25ob5 1233 3 rSLPI rslpi NN cord-006856-b1w25ob5 1234 1 ex ex NNP cord-006856-b1w25ob5 1234 2 vivo vivo NNP cord-006856-b1w25ob5 1234 3 represents represent VBZ cord-006856-b1w25ob5 1234 4 a a DT cord-006856-b1w25ob5 1234 5 promising promising JJ cord-006856-b1w25ob5 1234 6 therapeutic therapeutic JJ cord-006856-b1w25ob5 1234 7 option option NN cord-006856-b1w25ob5 1234 8 for for IN cord-006856-b1w25ob5 1234 9 modulating modulate VBG cord-006856-b1w25ob5 1234 10 the the DT cord-006856-b1w25ob5 1234 11 destructive destructive JJ cord-006856-b1w25ob5 1234 12 processes process NNS cord-006856-b1w25ob5 1234 13 of of IN cord-006856-b1w25ob5 1234 14 postischemic postischemic JJ cord-006856-b1w25ob5 1234 15 inflammation inflammation NN cord-006856-b1w25ob5 1234 16 while while IN cord-006856-b1w25ob5 1234 17 preserving preserve VBG cord-006856-b1w25ob5 1234 18 its -PRON- PRP$ cord-006856-b1w25ob5 1234 19 restorative restorative JJ cord-006856-b1w25ob5 1234 20 nature nature NN cord-006856-b1w25ob5 1234 21 . . . cord-006856-b1w25ob5 1235 1 Methodik Methodik NNP cord-006856-b1w25ob5 1235 2 . . . cord-006856-b1w25ob5 1236 1 Die die VB cord-006856-b1w25ob5 1237 1 Studie Studie NNP cord-006856-b1w25ob5 1237 2 wurde wurde VBD cord-006856-b1w25ob5 1237 3 an an DT cord-006856-b1w25ob5 1237 4 5 5 CD cord-006856-b1w25ob5 1237 5 Hausschweinen Hausschweinen NNP cord-006856-b1w25ob5 1237 6 durchgeführt durchgeführt NN cord-006856-b1w25ob5 1237 7 . . . cord-006856-b1w25ob5 1238 1 Die die VB cord-006856-b1w25ob5 1238 2 Tiere Tiere NNP cord-006856-b1w25ob5 1238 3 wurden wurden VBN cord-006856-b1w25ob5 1238 4 in in IN cord-006856-b1w25ob5 1238 5 Allgemeinnarkose Allgemeinnarkose NNP cord-006856-b1w25ob5 1238 6 versetzt versetzt VBN cord-006856-b1w25ob5 1238 7 und und IN cord-006856-b1w25ob5 1238 8 intubiert intubiert NNP cord-006856-b1w25ob5 1238 9 . . . cord-006856-b1w25ob5 1239 1 Alle Alle NNP cord-006856-b1w25ob5 1239 2 hämodynamischen hämodynamischen NNP cord-006856-b1w25ob5 1239 3 Daten Daten NNP cord-006856-b1w25ob5 1239 4 wurden wurden VBD cord-006856-b1w25ob5 1239 5 invasiv invasiv NNP cord-006856-b1w25ob5 1239 6 gemessen gemessen NNP cord-006856-b1w25ob5 1239 7 . . . cord-006856-b1w25ob5 1240 1 Die die VB cord-006856-b1w25ob5 1240 2 Parameter Parameter NNP cord-006856-b1w25ob5 1240 3 ( ( -LRB- cord-006856-b1w25ob5 1240 4 ABP ABP NNP cord-006856-b1w25ob5 1240 5 , , , cord-006856-b1w25ob5 1240 6 PAP pap NN cord-006856-b1w25ob5 1240 7 , , , cord-006856-b1w25ob5 1240 8 ZVD ZVD NNP cord-006856-b1w25ob5 1240 9 und und IN cord-006856-b1w25ob5 1240 10 LAP lap NN cord-006856-b1w25ob5 1240 11 ) ) -RRB- cord-006856-b1w25ob5 1240 12 wurden wurden VBD cord-006856-b1w25ob5 1240 13 wie wie VBP cord-006856-b1w25ob5 1240 14 in in IN cord-006856-b1w25ob5 1240 15 der der NNP cord-006856-b1w25ob5 1240 16 klinischen klinischen NNP cord-006856-b1w25ob5 1240 17 Praxis Praxis NNP cord-006856-b1w25ob5 1240 18 mit mit NNP cord-006856-b1w25ob5 1240 19 einem einem NNP cord-006856-b1w25ob5 1240 20 HP HP NNP cord-006856-b1w25ob5 1240 21 - - HYPH cord-006856-b1w25ob5 1240 22 Patientenmonitor Patientenmonitor NNP cord-006856-b1w25ob5 1240 23 registriert registriert NNP cord-006856-b1w25ob5 1240 24 und und VBD cord-006856-b1w25ob5 1240 25 gespeichert gespeichert NNP cord-006856-b1w25ob5 1240 26 . . . cord-006856-b1w25ob5 1241 1 Das Das NNP cord-006856-b1w25ob5 1241 2 Herzzeitvolumen Herzzeitvolumen NNP cord-006856-b1w25ob5 1241 3 ( ( -LRB- cord-006856-b1w25ob5 1241 4 CO CO NNP cord-006856-b1w25ob5 1241 5 ) ) -RRB- cord-006856-b1w25ob5 1241 6 wurde wurde NNP cord-006856-b1w25ob5 1242 1 mit mit NNP cord-006856-b1w25ob5 1242 2 Hilfe Hilfe NNP cord-006856-b1w25ob5 1242 3 eines eines NNP cord-006856-b1w25ob5 1242 4 Flowmeters Flowmeters NNPS cord-006856-b1w25ob5 1242 5 der der NNP cord-006856-b1w25ob5 1242 6 Firma Firma NNP cord-006856-b1w25ob5 1242 7 Transsonic Transsonic NNP cord-006856-b1w25ob5 1242 8 Systems Systems NNPS cord-006856-b1w25ob5 1242 9 Inc. Inc. NNP cord-006856-b1w25ob5 1242 10 gemessen gemessen NNP cord-006856-b1w25ob5 1242 11 . . . cord-006856-b1w25ob5 1243 1 Die die VB cord-006856-b1w25ob5 1243 2 hämodynamischen hämodynamischen NNP cord-006856-b1w25ob5 1244 1 Ausgangswerte Ausgangswerte NNP cord-006856-b1w25ob5 1244 2 von von NNP cord-006856-b1w25ob5 1244 3 4 4 CD cord-006856-b1w25ob5 1245 1 Patienten Patienten NNP cord-006856-b1w25ob5 1245 2 vor vor NN cord-006856-b1w25ob5 1245 3 ECMO ECMO NNP cord-006856-b1w25ob5 1245 4 wurden wurden VBD cord-006856-b1w25ob5 1245 5 retrospektiv retrospektiv NNP cord-006856-b1w25ob5 1245 6 mit mit NNP cord-006856-b1w25ob5 1245 7 den den NNP cord-006856-b1w25ob5 1245 8 experimentellen experimentellen NNP cord-006856-b1w25ob5 1245 9 Daten Daten NNP cord-006856-b1w25ob5 1245 10 verglichen verglichen NNP cord-006856-b1w25ob5 1245 11 . . . cord-006856-b1w25ob5 1246 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 1246 2 . . . cord-006856-b1w25ob5 1247 1 In in IN cord-006856-b1w25ob5 1247 2 der der NNP cord-006856-b1w25ob5 1247 3 Frühphase Frühphase NNP cord-006856-b1w25ob5 1247 4 des des NNP cord-006856-b1w25ob5 1248 1 Tierversuchs tierversuchs JJ cord-006856-b1w25ob5 1248 2 nach nach NNP cord-006856-b1w25ob5 1248 3 erfolgter erfolgter NN cord-006856-b1w25ob5 1248 4 Abklemmung Abklemmung NNP cord-006856-b1w25ob5 1248 5 blieb blieb NNP cord-006856-b1w25ob5 1249 1 ein ein VB cord-006856-b1w25ob5 1249 2 eindeutiger eindeutig JJR cord-006856-b1w25ob5 1250 1 Anstieg Anstieg NNP cord-006856-b1w25ob5 1250 2 des des NNP cord-006856-b1w25ob5 1251 1 PAP PAP NNP cord-006856-b1w25ob5 1251 2 bei bei NNP cord-006856-b1w25ob5 1251 3 4 4 CD cord-006856-b1w25ob5 1251 4 von von NNP cord-006856-b1w25ob5 1251 5 5 5 CD cord-006856-b1w25ob5 1251 6 Versuchstieren Versuchstieren NNP cord-006856-b1w25ob5 1251 7 aus aus NNP cord-006856-b1w25ob5 1251 8 . . . cord-006856-b1w25ob5 1252 1 Auch Auch NNP cord-006856-b1w25ob5 1252 2 ein ein NNP cord-006856-b1w25ob5 1252 3 rascher rascher NN cord-006856-b1w25ob5 1252 4 Abfall Abfall NNP cord-006856-b1w25ob5 1252 5 des des FW cord-006856-b1w25ob5 1252 6 CO CO NNP cord-006856-b1w25ob5 1252 7 war war NN cord-006856-b1w25ob5 1252 8 nicht nicht FW cord-006856-b1w25ob5 1252 9 zu zu NNP cord-006856-b1w25ob5 1252 10 beobachten beobachten NNP cord-006856-b1w25ob5 1252 11 . . . cord-006856-b1w25ob5 1253 1 Auch Auch NNP cord-006856-b1w25ob5 1253 2 der der NN cord-006856-b1w25ob5 1253 3 PVR pvr NN cord-006856-b1w25ob5 1253 4 zeigte zeigte NN cord-006856-b1w25ob5 1253 5 keine keine NN cord-006856-b1w25ob5 1253 6 signifikante signifikante NNP cord-006856-b1w25ob5 1253 7 Veränderung Veränderung NNP cord-006856-b1w25ob5 1253 8 . . . cord-006856-b1w25ob5 1254 1 Die die VB cord-006856-b1w25ob5 1254 2 PAP PAP NNP cord-006856-b1w25ob5 1254 3 / / SYM cord-006856-b1w25ob5 1254 4 AP AP NNP cord-006856-b1w25ob5 1254 5 - - HYPH cord-006856-b1w25ob5 1254 6 Druckratio Druckratio NNP cord-006856-b1w25ob5 1254 7 reagierte reagierte IN cord-006856-b1w25ob5 1254 8 sehr sehr NNP cord-006856-b1w25ob5 1254 9 rasch rasch NNP cord-006856-b1w25ob5 1255 1 und und NNP cord-006856-b1w25ob5 1255 2 in in IN cord-006856-b1w25ob5 1255 3 allen allen NNP cord-006856-b1w25ob5 1255 4 Fällen Fällen NNP cord-006856-b1w25ob5 1255 5 mit mit NNP cord-006856-b1w25ob5 1255 6 einem einem NNP cord-006856-b1w25ob5 1255 7 Anstieg Anstieg NNP cord-006856-b1w25ob5 1255 8 auf auf NNP cord-006856-b1w25ob5 1255 9 das das NNP cord-006856-b1w25ob5 1255 10 Ereignis Ereignis NNP cord-006856-b1w25ob5 1255 11 . . . cord-006856-b1w25ob5 1256 1 Von Von NNP cord-006856-b1w25ob5 1256 2 4 4 CD cord-006856-b1w25ob5 1256 3 Patienten Patienten NNP cord-006856-b1w25ob5 1256 4 , , , cord-006856-b1w25ob5 1256 5 die die VB cord-006856-b1w25ob5 1256 6 mittels mittels NNP cord-006856-b1w25ob5 1256 7 ECMO ECMO NNP cord-006856-b1w25ob5 1256 8 erfolgreich erfolgreich NNP cord-006856-b1w25ob5 1256 9 therapiert therapiert NNP cord-006856-b1w25ob5 1256 10 worden worden NNP cord-006856-b1w25ob5 1256 11 waren waren NNP cord-006856-b1w25ob5 1256 12 , , , cord-006856-b1w25ob5 1256 13 hatten hatten NNP cord-006856-b1w25ob5 1256 14 3 3 CD cord-006856-b1w25ob5 1256 15 eine eine NNP cord-006856-b1w25ob5 1256 16 PAP PAP NNP cord-006856-b1w25ob5 1256 17 / / SYM cord-006856-b1w25ob5 1256 18 AP AP NNP cord-006856-b1w25ob5 1256 19 - - HYPH cord-006856-b1w25ob5 1256 20 Ratio ratio NN cord-006856-b1w25ob5 1256 21 über über NN cord-006856-b1w25ob5 1256 22 0,3 0,3 NNP cord-006856-b1w25ob5 1256 23 , , , cord-006856-b1w25ob5 1256 24 ein ein NNP cord-006856-b1w25ob5 1256 25 Patient Patient NNP cord-006856-b1w25ob5 1256 26 hatte hatte NNP cord-006856-b1w25ob5 1256 27 eine eine NNP cord-006856-b1w25ob5 1256 28 PAP PAP NNP cord-006856-b1w25ob5 1256 29 / / SYM cord-006856-b1w25ob5 1256 30 AP AP NNP cord-006856-b1w25ob5 1256 31 - - HYPH cord-006856-b1w25ob5 1256 32 Ratio Ratio NNP cord-006856-b1w25ob5 1256 33 von von NNP cord-006856-b1w25ob5 1256 34 0,26 0,26 CD cord-006856-b1w25ob5 1256 35 . . . cord-006856-b1w25ob5 1257 1 Die die VB cord-006856-b1w25ob5 1258 1 Patienten Patienten NNP cord-006856-b1w25ob5 1258 2 mit mit NNP cord-006856-b1w25ob5 1258 3 PAP PAP NNP cord-006856-b1w25ob5 1258 4 / / SYM cord-006856-b1w25ob5 1258 5 AP AP NNP cord-006856-b1w25ob5 1258 6 über über NNP cord-006856-b1w25ob5 1258 7 0,3 0,3 CD cord-006856-b1w25ob5 1258 8 wurden wurden NNP cord-006856-b1w25ob5 1258 9 mittels mittels NNPS cord-006856-b1w25ob5 1258 10 VA VA NNP cord-006856-b1w25ob5 1258 11 - - HYPH cord-006856-b1w25ob5 1258 12 ECMO ECMO NNP cord-006856-b1w25ob5 1258 13 therapiert therapiert NN cord-006856-b1w25ob5 1258 14 , , , cord-006856-b1w25ob5 1258 15 der der NNP cord-006856-b1w25ob5 1258 16 Patient Patient NNP cord-006856-b1w25ob5 1258 17 mit mit NNP cord-006856-b1w25ob5 1258 18 PAP PAP NNP cord-006856-b1w25ob5 1258 19 / / SYM cord-006856-b1w25ob5 1258 20 AP AP NNP cord-006856-b1w25ob5 1258 21 von von NNP cord-006856-b1w25ob5 1258 22 0,26 0,26 CD cord-006856-b1w25ob5 1258 23 mittels mittels NNP cord-006856-b1w25ob5 1258 24 VV VV NNP cord-006856-b1w25ob5 1258 25 - - HYPH cord-006856-b1w25ob5 1258 26 ECMO ECMO NNP cord-006856-b1w25ob5 1258 27 . . . cord-006856-b1w25ob5 1259 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 1259 2 . . . cord-006856-b1w25ob5 1260 1 Isolierte Isolierte NNP cord-006856-b1w25ob5 1260 2 Veränderungen Veränderungen NNP cord-006856-b1w25ob5 1260 3 der der NNP cord-006856-b1w25ob5 1260 4 pulmonalen pulmonalen NNP cord-006856-b1w25ob5 1260 5 Hämodynamik Hämodynamik NNP cord-006856-b1w25ob5 1260 6 repräsentieren repräsentieren NNP cord-006856-b1w25ob5 1260 7 offenbar offenbar NNP cord-006856-b1w25ob5 1261 1 nur nur NNP cord-006856-b1w25ob5 1261 2 bedingt bedingt NNP cord-006856-b1w25ob5 1261 3 den den NNP cord-006856-b1w25ob5 1261 4 Schweregrad Schweregrad NNP cord-006856-b1w25ob5 1261 5 der der NN cord-006856-b1w25ob5 1261 6 vorhandenen vorhandenen NNP cord-006856-b1w25ob5 1261 7 Beeinträchtigung Beeinträchtigung NNP cord-006856-b1w25ob5 1261 8 . . . cord-006856-b1w25ob5 1262 1 Als Als NNP cord-006856-b1w25ob5 1262 2 wichtiger wichtiger NNP cord-006856-b1w25ob5 1262 3 Parameter Parameter NNP cord-006856-b1w25ob5 1262 4 für für IN cord-006856-b1w25ob5 1262 5 eine eine NNP cord-006856-b1w25ob5 1262 6 rasche rasche NN cord-006856-b1w25ob5 1262 7 Einschätzung Einschätzung NNP cord-006856-b1w25ob5 1262 8 des des NNP cord-006856-b1w25ob5 1262 9 Grades Grades NNP cord-006856-b1w25ob5 1262 10 der der NNP cord-006856-b1w25ob5 1262 11 Kompromittierung Kompromittierung NNP cord-006856-b1w25ob5 1262 12 kann kann NNP cord-006856-b1w25ob5 1262 13 die die VB cord-006856-b1w25ob5 1262 14 Druckratio Druckratio NNP cord-006856-b1w25ob5 1262 15 zwischen zwischen NNP cord-006856-b1w25ob5 1262 16 pulmonalem pulmonalem NN cord-006856-b1w25ob5 1262 17 und und IN cord-006856-b1w25ob5 1262 18 systemischem systemischem NNP cord-006856-b1w25ob5 1262 19 Kreislauf Kreislauf NNP cord-006856-b1w25ob5 1262 20 angesehen angesehen NNP cord-006856-b1w25ob5 1262 21 werden werden NNP cord-006856-b1w25ob5 1262 22 . . . cord-006856-b1w25ob5 1263 1 Als Als NNP cord-006856-b1w25ob5 1263 2 leicht leicht NNP cord-006856-b1w25ob5 1263 3 zu zu NNP cord-006856-b1w25ob5 1263 4 erhebender erhebender NNP cord-006856-b1w25ob5 1263 5 Parameter Parameter NNP cord-006856-b1w25ob5 1263 6 könnte könnte NNP cord-006856-b1w25ob5 1263 7 die die VBP cord-006856-b1w25ob5 1264 1 PAP PAP NNP cord-006856-b1w25ob5 1264 2 / / SYM cord-006856-b1w25ob5 1264 3 AP AP NNP cord-006856-b1w25ob5 1264 4 - - HYPH cord-006856-b1w25ob5 1264 5 Ratio Ratio NNP cord-006856-b1w25ob5 1264 6 eine eine NNP cord-006856-b1w25ob5 1264 7 Entscheidungsgrundlage Entscheidungsgrundlage NNP cord-006856-b1w25ob5 1264 8 für für NNS cord-006856-b1w25ob5 1264 9 die die VBP cord-006856-b1w25ob5 1264 10 zu zu NNP cord-006856-b1w25ob5 1264 11 wählende wählende NNP cord-006856-b1w25ob5 1264 12 ECMO ECMO NNP cord-006856-b1w25ob5 1264 13 - - HYPH cord-006856-b1w25ob5 1264 14 Konfiguration Konfiguration NNP cord-006856-b1w25ob5 1264 15 darstellen darstellen NNS cord-006856-b1w25ob5 1264 16 . . . cord-006856-b1w25ob5 1265 1 Nach Nach NNP cord-006856-b1w25ob5 1265 2 den den NNP cord-006856-b1w25ob5 1265 3 bisherigen bisherigen NNP cord-006856-b1w25ob5 1265 4 Erfahrungen Erfahrungen NNP cord-006856-b1w25ob5 1265 5 wäre wäre NNP cord-006856-b1w25ob5 1265 6 die die VBP cord-006856-b1w25ob5 1265 7 Indikationsgrenze Indikationsgrenze NNP cord-006856-b1w25ob5 1265 8 bei bei FW cord-006856-b1w25ob5 1265 9 einer einer NNP cord-006856-b1w25ob5 1265 10 PAP PAP NNP cord-006856-b1w25ob5 1265 11 / / SYM cord-006856-b1w25ob5 1265 12 AP AP NNP cord-006856-b1w25ob5 1265 13 - - HYPH cord-006856-b1w25ob5 1265 14 Ratio Ratio NNP cord-006856-b1w25ob5 1265 15 von von NN cord-006856-b1w25ob5 1265 16 etwa etwa NNP cord-006856-b1w25ob5 1265 17 0,3 0,3 CD cord-006856-b1w25ob5 1265 18 zu zu NNP cord-006856-b1w25ob5 1265 19 ziehen ziehen NNP cord-006856-b1w25ob5 1265 20 . . . cord-006856-b1w25ob5 1266 1 Background background NN cord-006856-b1w25ob5 1266 2 . . . cord-006856-b1w25ob5 1267 1 Pancreas pancreas NN cord-006856-b1w25ob5 1267 2 transplantation transplantation NN cord-006856-b1w25ob5 1267 3 in in IN cord-006856-b1w25ob5 1267 4 the the DT cord-006856-b1w25ob5 1267 5 mouse mouse NN cord-006856-b1w25ob5 1267 6 is be VBZ cord-006856-b1w25ob5 1267 7 an an DT cord-006856-b1w25ob5 1267 8 extremely extremely RB cord-006856-b1w25ob5 1267 9 demanding demanding JJ cord-006856-b1w25ob5 1267 10 procedure procedure NN cord-006856-b1w25ob5 1267 11 and and CC cord-006856-b1w25ob5 1267 12 severe severe JJ cord-006856-b1w25ob5 1267 13 technical technical JJ cord-006856-b1w25ob5 1267 14 problems problem NNS cord-006856-b1w25ob5 1267 15 have have VBP cord-006856-b1w25ob5 1267 16 limited limit VBN cord-006856-b1w25ob5 1267 17 its -PRON- PRP$ cord-006856-b1w25ob5 1267 18 widespread widespread JJ cord-006856-b1w25ob5 1267 19 use use NN cord-006856-b1w25ob5 1267 20 . . . cord-006856-b1w25ob5 1268 1 Since since IN cord-006856-b1w25ob5 1268 2 the the DT cord-006856-b1w25ob5 1268 3 mouse mouse NN cord-006856-b1w25ob5 1268 4 , , , cord-006856-b1w25ob5 1268 5 however however RB cord-006856-b1w25ob5 1268 6 , , , cord-006856-b1w25ob5 1268 7 would would MD cord-006856-b1w25ob5 1268 8 be be VB cord-006856-b1w25ob5 1268 9 a a DT cord-006856-b1w25ob5 1268 10 good good JJ cord-006856-b1w25ob5 1268 11 model model NN cord-006856-b1w25ob5 1268 12 for for IN cord-006856-b1w25ob5 1268 13 the the DT cord-006856-b1w25ob5 1268 14 study study NN cord-006856-b1w25ob5 1268 15 of of IN cord-006856-b1w25ob5 1268 16 various various JJ cord-006856-b1w25ob5 1268 17 transplantation transplantation NN cord-006856-b1w25ob5 1268 18 - - HYPH cord-006856-b1w25ob5 1268 19 related relate VBN cord-006856-b1w25ob5 1268 20 problems problem NNS cord-006856-b1w25ob5 1268 21 , , , cord-006856-b1w25ob5 1268 22 such such JJ cord-006856-b1w25ob5 1268 23 as as IN cord-006856-b1w25ob5 1268 24 ischemia ischemia NN cord-006856-b1w25ob5 1268 25 - - HYPH cord-006856-b1w25ob5 1268 26 reperfusion reperfusion NN cord-006856-b1w25ob5 1268 27 injury injury NN cord-006856-b1w25ob5 1268 28 or or CC cord-006856-b1w25ob5 1268 29 graft graft NN cord-006856-b1w25ob5 1268 30 pancreatitis pancreatitis NN cord-006856-b1w25ob5 1268 31 , , , cord-006856-b1w25ob5 1268 32 we -PRON- PRP cord-006856-b1w25ob5 1268 33 designed design VBD cord-006856-b1w25ob5 1268 34 a a DT cord-006856-b1w25ob5 1268 35 new new JJ cord-006856-b1w25ob5 1268 36 surgical surgical JJ cord-006856-b1w25ob5 1268 37 strategy strategy NN cord-006856-b1w25ob5 1268 38 for for IN cord-006856-b1w25ob5 1268 39 cervical cervical JJ cord-006856-b1w25ob5 1268 40 heterotopic heterotopic NNP cord-006856-b1w25ob5 1268 41 vascularized vascularized JJ cord-006856-b1w25ob5 1268 42 pancreas pancreas NN cord-006856-b1w25ob5 1268 43 transplantation transplantation NN cord-006856-b1w25ob5 1268 44 using use VBG cord-006856-b1w25ob5 1268 45 a a DT cord-006856-b1w25ob5 1268 46 cuff cuff NN cord-006856-b1w25ob5 1268 47 technique technique NN cord-006856-b1w25ob5 1268 48 . . . cord-006856-b1w25ob5 1269 1 Methods method NNS cord-006856-b1w25ob5 1269 2 . . . cord-006856-b1w25ob5 1270 1 Male male JJ cord-006856-b1w25ob5 1270 2 syngeneic syngeneic NNS cord-006856-b1w25ob5 1270 3 C57BL6 c57bl6 NN cord-006856-b1w25ob5 1270 4 ( ( -LRB- cord-006856-b1w25ob5 1270 5 H-2 H-2 NNP cord-006856-b1w25ob5 1270 6 b b NN cord-006856-b1w25ob5 1270 7 ) ) -RRB- cord-006856-b1w25ob5 1270 8 mice mice NN cord-006856-b1w25ob5 1270 9 ( ( -LRB- cord-006856-b1w25ob5 1270 10 n n NN cord-006856-b1w25ob5 1270 11 = = SYM cord-006856-b1w25ob5 1270 12 27 27 CD cord-006856-b1w25ob5 1270 13 ) ) -RRB- cord-006856-b1w25ob5 1271 1 10-to 10-to CD cord-006856-b1w25ob5 1271 2 12-week 12-week JJ cord-006856-b1w25ob5 1271 3 - - HYPH cord-006856-b1w25ob5 1271 4 old old JJ cord-006856-b1w25ob5 1271 5 were be VBD cord-006856-b1w25ob5 1271 6 used use VBN cord-006856-b1w25ob5 1271 7 as as IN cord-006856-b1w25ob5 1271 8 size size NN cord-006856-b1w25ob5 1271 9 - - HYPH cord-006856-b1w25ob5 1271 10 matched match VBN cord-006856-b1w25ob5 1271 11 donor donor NN cord-006856-b1w25ob5 1271 12 and and CC cord-006856-b1w25ob5 1271 13 recipient recipient NN cord-006856-b1w25ob5 1271 14 pairs pair NNS cord-006856-b1w25ob5 1271 15 . . . cord-006856-b1w25ob5 1272 1 Recipients recipient NNS cord-006856-b1w25ob5 1272 2 were be VBD cord-006856-b1w25ob5 1272 3 intraperitoneally intraperitoneally RB cord-006856-b1w25ob5 1272 4 injected inject VBN cord-006856-b1w25ob5 1272 5 with with IN cord-006856-b1w25ob5 1272 6 312.5 312.5 CD cord-006856-b1w25ob5 1272 7 mg mg NN cord-006856-b1w25ob5 1272 8 of of IN cord-006856-b1w25ob5 1272 9 streptozotocin streptozotocin NNS cord-006856-b1w25ob5 1272 10 per per IN cord-006856-b1w25ob5 1272 11 kg kg NN cord-006856-b1w25ob5 1272 12 in in IN cord-006856-b1w25ob5 1272 13 order order NN cord-006856-b1w25ob5 1272 14 to to TO cord-006856-b1w25ob5 1272 15 become become VB cord-006856-b1w25ob5 1272 16 hyperglycemic hyperglycemic JJ cord-006856-b1w25ob5 1272 17 ( ( -LRB- cord-006856-b1w25ob5 1272 18 blood blood NN cord-006856-b1w25ob5 1272 19 glucose glucose NN cord-006856-b1w25ob5 1272 20 , , , cord-006856-b1w25ob5 1272 21 > > XX cord-006856-b1w25ob5 1272 22 300 300 CD cord-006856-b1w25ob5 1272 23 mg mg NNP cord-006856-b1w25ob5 1272 24 / / SYM cord-006856-b1w25ob5 1272 25 dl dl NNP cord-006856-b1w25ob5 1272 26 ) ) -RRB- cord-006856-b1w25ob5 1272 27 and and CC cord-006856-b1w25ob5 1272 28 transplantation transplantation NN cord-006856-b1w25ob5 1272 29 was be VBD cord-006856-b1w25ob5 1272 30 performed perform VBN cord-006856-b1w25ob5 1272 31 4 4 CD cord-006856-b1w25ob5 1272 32 days day NNS cord-006856-b1w25ob5 1272 33 later later RB cord-006856-b1w25ob5 1272 34 . . . cord-006856-b1w25ob5 1273 1 Recipient recipient NN cord-006856-b1w25ob5 1273 2 operation operation NN cord-006856-b1w25ob5 1273 3 : : : cord-006856-b1w25ob5 1273 4 The the DT cord-006856-b1w25ob5 1273 5 right right JJ cord-006856-b1w25ob5 1273 6 external external JJ cord-006856-b1w25ob5 1273 7 jugular jugular NN cord-006856-b1w25ob5 1273 8 vein vein NN cord-006856-b1w25ob5 1273 9 ( ( -LRB- cord-006856-b1w25ob5 1273 10 EJV EJV NNP cord-006856-b1w25ob5 1273 11 ) ) -RRB- cord-006856-b1w25ob5 1273 12 and and CC cord-006856-b1w25ob5 1273 13 common common JJ cord-006856-b1w25ob5 1273 14 carotid carotid JJ cord-006856-b1w25ob5 1273 15 artery artery NN cord-006856-b1w25ob5 1273 16 were be VBD cord-006856-b1w25ob5 1273 17 dissected dissect VBN cord-006856-b1w25ob5 1273 18 free free JJ cord-006856-b1w25ob5 1273 19 . . . cord-006856-b1w25ob5 1274 1 By by IN cord-006856-b1w25ob5 1274 2 using use VBG cord-006856-b1w25ob5 1274 3 a a DT cord-006856-b1w25ob5 1274 4 polyethylen polyethylen JJ cord-006856-b1w25ob5 1274 5 cuff cuff NN cord-006856-b1w25ob5 1274 6 ( ( -LRB- cord-006856-b1w25ob5 1274 7 OD OD NNP cord-006856-b1w25ob5 1274 8 , , , cord-006856-b1w25ob5 1274 9 0.63 0.63 CD cord-006856-b1w25ob5 1274 10 mm mm NN cord-006856-b1w25ob5 1274 11 ) ) -RRB- cord-006856-b1w25ob5 1274 12 it -PRON- PRP cord-006856-b1w25ob5 1274 13 became become VBD cord-006856-b1w25ob5 1274 14 possible possible JJ cord-006856-b1w25ob5 1274 15 to to TO cord-006856-b1w25ob5 1274 16 evert evert VB cord-006856-b1w25ob5 1274 17 the the DT cord-006856-b1w25ob5 1274 18 artery artery NN cord-006856-b1w25ob5 1274 19 over over IN cord-006856-b1w25ob5 1274 20 the the DT cord-006856-b1w25ob5 1274 21 cuff cuff NN cord-006856-b1w25ob5 1274 22 body body NN cord-006856-b1w25ob5 1274 23 and and CC cord-006856-b1w25ob5 1274 24 finally finally RB cord-006856-b1w25ob5 1274 25 fix fix VB cord-006856-b1w25ob5 1274 26 the the DT cord-006856-b1w25ob5 1274 27 vessel vessel NN cord-006856-b1w25ob5 1274 28 with with IN cord-006856-b1w25ob5 1274 29 8 8 CD cord-006856-b1w25ob5 1274 30 - - SYM cord-006856-b1w25ob5 1274 31 0 0 CD cord-006856-b1w25ob5 1274 32 silk silk NN cord-006856-b1w25ob5 1274 33 ligatures ligature NNS cord-006856-b1w25ob5 1274 34 . . . cord-006856-b1w25ob5 1275 1 Similarly similarly RB cord-006856-b1w25ob5 1275 2 , , , cord-006856-b1w25ob5 1275 3 the the DT cord-006856-b1w25ob5 1275 4 EJV EJV NNP cord-006856-b1w25ob5 1275 5 could could MD cord-006856-b1w25ob5 1275 6 be be VB cord-006856-b1w25ob5 1275 7 everted evert VBN cord-006856-b1w25ob5 1275 8 over over IN cord-006856-b1w25ob5 1275 9 a a DT cord-006856-b1w25ob5 1275 10 0.94 0.94 CD cord-006856-b1w25ob5 1275 11 mm mm NNP cord-006856-b1w25ob5 1275 12 cuff cuff NN cord-006856-b1w25ob5 1275 13 . . . cord-006856-b1w25ob5 1276 1 Donor donor NN cord-006856-b1w25ob5 1276 2 operation operation NN cord-006856-b1w25ob5 1276 3 : : : cord-006856-b1w25ob5 1276 4 After after IN cord-006856-b1w25ob5 1276 5 a a DT cord-006856-b1w25ob5 1276 6 complete complete JJ cord-006856-b1w25ob5 1276 7 midline midline JJ cord-006856-b1w25ob5 1276 8 incision incision NN cord-006856-b1w25ob5 1276 9 the the DT cord-006856-b1w25ob5 1276 10 pancreas pancreas NN cord-006856-b1w25ob5 1276 11 was be VBD cord-006856-b1w25ob5 1276 12 isolated isolate VBN cord-006856-b1w25ob5 1276 13 using use VBG cord-006856-b1w25ob5 1276 14 a a DT cord-006856-b1w25ob5 1276 15 no no DT cord-006856-b1w25ob5 1276 16 - - HYPH cord-006856-b1w25ob5 1276 17 touch touch NN cord-006856-b1w25ob5 1276 18 technique technique NN cord-006856-b1w25ob5 1276 19 on on IN cord-006856-b1w25ob5 1276 20 a a DT cord-006856-b1w25ob5 1276 21 segment segment NN cord-006856-b1w25ob5 1276 22 of of IN cord-006856-b1w25ob5 1276 23 the the DT cord-006856-b1w25ob5 1276 24 aorta aorta NN cord-006856-b1w25ob5 1276 25 , , , cord-006856-b1w25ob5 1276 26 including include VBG cord-006856-b1w25ob5 1276 27 the the DT cord-006856-b1w25ob5 1276 28 celiac celiac JJ cord-006856-b1w25ob5 1276 29 axis axis NN cord-006856-b1w25ob5 1276 30 and and CC cord-006856-b1w25ob5 1276 31 the the DT cord-006856-b1w25ob5 1276 32 superior superior JJ cord-006856-b1w25ob5 1276 33 mesenteric mesenteric JJ cord-006856-b1w25ob5 1276 34 artery artery NN cord-006856-b1w25ob5 1276 35 . . . cord-006856-b1w25ob5 1277 1 The the DT cord-006856-b1w25ob5 1277 2 venous venous JJ cord-006856-b1w25ob5 1277 3 outflow outflow NN cord-006856-b1w25ob5 1277 4 was be VBD cord-006856-b1w25ob5 1277 5 provided provide VBN cord-006856-b1w25ob5 1277 6 by by IN cord-006856-b1w25ob5 1277 7 the the DT cord-006856-b1w25ob5 1277 8 portal portal JJ cord-006856-b1w25ob5 1277 9 vein vein NN cord-006856-b1w25ob5 1277 10 . . . cord-006856-b1w25ob5 1278 1 All all DT cord-006856-b1w25ob5 1278 2 grafts graft NNS cord-006856-b1w25ob5 1278 3 were be VBD cord-006856-b1w25ob5 1278 4 flushed flush VBN cord-006856-b1w25ob5 1278 5 with with IN cord-006856-b1w25ob5 1278 6 4 4 CD cord-006856-b1w25ob5 1278 7 ° ° NN cord-006856-b1w25ob5 1278 8 C c NN cord-006856-b1w25ob5 1278 9 saline saline NN cord-006856-b1w25ob5 1278 10 solution solution NN cord-006856-b1w25ob5 1278 11 . . . cord-006856-b1w25ob5 1279 1 Implantation implantation NN cord-006856-b1w25ob5 1279 2 : : : cord-006856-b1w25ob5 1280 1 The the DT cord-006856-b1w25ob5 1280 2 graft graft NN cord-006856-b1w25ob5 1280 3 was be VBD cord-006856-b1w25ob5 1280 4 placed place VBN cord-006856-b1w25ob5 1280 5 in in IN cord-006856-b1w25ob5 1280 6 the the DT cord-006856-b1w25ob5 1280 7 right right JJ cord-006856-b1w25ob5 1280 8 cervical cervical JJ cord-006856-b1w25ob5 1280 9 region region NN cord-006856-b1w25ob5 1280 10 and and CC cord-006856-b1w25ob5 1280 11 vascular vascular JJ cord-006856-b1w25ob5 1280 12 anastomoses anastomosis NNS cord-006856-b1w25ob5 1280 13 completed complete VBN cord-006856-b1w25ob5 1280 14 by by IN cord-006856-b1w25ob5 1280 15 pulling pull VBG cord-006856-b1w25ob5 1280 16 the the DT cord-006856-b1w25ob5 1280 17 PV pv NN cord-006856-b1w25ob5 1280 18 over over IN cord-006856-b1w25ob5 1280 19 the the DT cord-006856-b1w25ob5 1280 20 EJV EJV NNP cord-006856-b1w25ob5 1280 21 cuff cuff NN cord-006856-b1w25ob5 1280 22 and and CC cord-006856-b1w25ob5 1280 23 the the DT cord-006856-b1w25ob5 1280 24 donor donor NN cord-006856-b1w25ob5 1280 25 aortic aortic JJ cord-006856-b1w25ob5 1280 26 segment segment NN cord-006856-b1w25ob5 1280 27 over over IN cord-006856-b1w25ob5 1280 28 the the DT cord-006856-b1w25ob5 1280 29 carotid carotid JJ cord-006856-b1w25ob5 1280 30 cuff cuff NN cord-006856-b1w25ob5 1280 31 and and CC cord-006856-b1w25ob5 1280 32 held hold VBD cord-006856-b1w25ob5 1280 33 in in IN cord-006856-b1w25ob5 1280 34 place place NN cord-006856-b1w25ob5 1280 35 with with IN cord-006856-b1w25ob5 1280 36 a a DT cord-006856-b1w25ob5 1280 37 8 8 CD cord-006856-b1w25ob5 1280 38 - - SYM cord-006856-b1w25ob5 1280 39 0 0 CD cord-006856-b1w25ob5 1280 40 silk silk NN cord-006856-b1w25ob5 1280 41 ligature ligature NN cord-006856-b1w25ob5 1280 42 . . . cord-006856-b1w25ob5 1281 1 After after IN cord-006856-b1w25ob5 1281 2 releasing release VBG cord-006856-b1w25ob5 1281 3 venous venous JJ cord-006856-b1w25ob5 1281 4 and and CC cord-006856-b1w25ob5 1281 5 arterial arterial JJ cord-006856-b1w25ob5 1281 6 clamps clamp NNS cord-006856-b1w25ob5 1281 7 , , , cord-006856-b1w25ob5 1281 8 all all DT cord-006856-b1w25ob5 1281 9 grafts graft NNS cord-006856-b1w25ob5 1281 10 immediately immediately RB cord-006856-b1w25ob5 1281 11 returned return VBD cord-006856-b1w25ob5 1281 12 to to IN cord-006856-b1w25ob5 1281 13 their -PRON- PRP$ cord-006856-b1w25ob5 1281 14 normal normal JJ cord-006856-b1w25ob5 1281 15 pink pink JJ cord-006856-b1w25ob5 1281 16 color color NN cord-006856-b1w25ob5 1281 17 with with IN cord-006856-b1w25ob5 1281 18 the the DT cord-006856-b1w25ob5 1281 19 arterial arterial JJ cord-006856-b1w25ob5 1281 20 stump stump NN cord-006856-b1w25ob5 1281 21 pulsating pulsate VBG cord-006856-b1w25ob5 1281 22 . . . cord-006856-b1w25ob5 1282 1 Results result NNS cord-006856-b1w25ob5 1282 2 . . . cord-006856-b1w25ob5 1283 1 Out out IN cord-006856-b1w25ob5 1283 2 of of IN cord-006856-b1w25ob5 1283 3 27 27 CD cord-006856-b1w25ob5 1283 4 recipients recipient NNS cord-006856-b1w25ob5 1283 5 , , , cord-006856-b1w25ob5 1283 6 surviving survive VBG cord-006856-b1w25ob5 1283 7 over over IN cord-006856-b1w25ob5 1283 8 50 50 CD cord-006856-b1w25ob5 1283 9 days day NNS cord-006856-b1w25ob5 1283 10 , , , cord-006856-b1w25ob5 1283 11 2 2 CD cord-006856-b1w25ob5 1283 12 animals animal NNS cord-006856-b1w25ob5 1283 13 died die VBD cord-006856-b1w25ob5 1283 14 from from IN cord-006856-b1w25ob5 1283 15 haemorrhage haemorrhage NN cord-006856-b1w25ob5 1283 16 ( ( -LRB- cord-006856-b1w25ob5 1283 17 survival survival NN cord-006856-b1w25ob5 1283 18 rate rate NN cord-006856-b1w25ob5 1283 19 , , , cord-006856-b1w25ob5 1283 20 93 93 CD cord-006856-b1w25ob5 1283 21 % % NN cord-006856-b1w25ob5 1283 22 ) ) -RRB- cord-006856-b1w25ob5 1283 23 . . . cord-006856-b1w25ob5 1284 1 Donor donor NN cord-006856-b1w25ob5 1284 2 operation operation NN cord-006856-b1w25ob5 1284 3 lasted last VBD cord-006856-b1w25ob5 1284 4 40 40 CD cord-006856-b1w25ob5 1284 5 ± ± CD cord-006856-b1w25ob5 1284 6 5 5 CD cord-006856-b1w25ob5 1284 7 min min NN cord-006856-b1w25ob5 1284 8 and and CC cord-006856-b1w25ob5 1284 9 dissection dissection NN cord-006856-b1w25ob5 1284 10 of of IN cord-006856-b1w25ob5 1284 11 recipient recipient NN cord-006856-b1w25ob5 1284 12 vessels vessel NNS cord-006856-b1w25ob5 1284 13 took take VBD cord-006856-b1w25ob5 1284 14 20 20 CD cord-006856-b1w25ob5 1284 15 ± ± NNP cord-006856-b1w25ob5 1284 16 4 4 CD cord-006856-b1w25ob5 1284 17 min min NN cord-006856-b1w25ob5 1284 18 . . . cord-006856-b1w25ob5 1285 1 Implantation implantation NN cord-006856-b1w25ob5 1285 2 time time NN cord-006856-b1w25ob5 1285 3 was be VBD cord-006856-b1w25ob5 1285 4 4 4 CD cord-006856-b1w25ob5 1285 5 to to IN cord-006856-b1w25ob5 1285 6 6 6 CD cord-006856-b1w25ob5 1285 7 min min NN cord-006856-b1w25ob5 1285 8 , , , cord-006856-b1w25ob5 1285 9 resulting result VBG cord-006856-b1w25ob5 1285 10 in in IN cord-006856-b1w25ob5 1285 11 a a DT cord-006856-b1w25ob5 1285 12 total total JJ cord-006856-b1w25ob5 1285 13 pancreas pancreas NN cord-006856-b1w25ob5 1285 14 ischemia ischemia NN cord-006856-b1w25ob5 1285 15 time time NN cord-006856-b1w25ob5 1285 16 of of IN cord-006856-b1w25ob5 1285 17 33 33 CD cord-006856-b1w25ob5 1285 18 ± ± CD cord-006856-b1w25ob5 1285 19 6 6 CD cord-006856-b1w25ob5 1285 20 min min NN cord-006856-b1w25ob5 1285 21 . . . cord-006856-b1w25ob5 1286 1 No no DT cord-006856-b1w25ob5 1286 2 thromboembolic thromboembolic JJ cord-006856-b1w25ob5 1286 3 complications complication NNS cord-006856-b1w25ob5 1286 4 at at IN cord-006856-b1w25ob5 1286 5 the the DT cord-006856-b1w25ob5 1286 6 cuff cuff NN cord-006856-b1w25ob5 1286 7 side side NN cord-006856-b1w25ob5 1286 8 were be VBD cord-006856-b1w25ob5 1286 9 observed observe VBN cord-006856-b1w25ob5 1286 10 . . . cord-006856-b1w25ob5 1287 1 Preoperative preoperative JJ cord-006856-b1w25ob5 1287 2 glucose glucose NN cord-006856-b1w25ob5 1287 3 levels level NNS cord-006856-b1w25ob5 1287 4 were be VBD cord-006856-b1w25ob5 1287 5 518 518 CD cord-006856-b1w25ob5 1287 6 ± ± CD cord-006856-b1w25ob5 1287 7 59 59 CD cord-006856-b1w25ob5 1287 8 mg mg NNP cord-006856-b1w25ob5 1287 9 / / SYM cord-006856-b1w25ob5 1287 10 dl dl NNP cord-006856-b1w25ob5 1287 11 and and CC cord-006856-b1w25ob5 1287 12 could could MD cord-006856-b1w25ob5 1287 13 all all RB cord-006856-b1w25ob5 1287 14 be be VB cord-006856-b1w25ob5 1287 15 normalized normalize VBN cord-006856-b1w25ob5 1287 16 by by IN cord-006856-b1w25ob5 1287 17 po po NNP cord-006856-b1w25ob5 1287 18 day day NNP cord-006856-b1w25ob5 1287 19 1 1 CD cord-006856-b1w25ob5 1287 20 ( ( -LRB- cord-006856-b1w25ob5 1287 21 88 88 CD cord-006856-b1w25ob5 1287 22 ± ± CD cord-006856-b1w25ob5 1287 23 13 13 CD cord-006856-b1w25ob5 1287 24 mg mg NNP cord-006856-b1w25ob5 1287 25 / / SYM cord-006856-b1w25ob5 1287 26 dl dl NNP cord-006856-b1w25ob5 1287 27 ) ) -RRB- cord-006856-b1w25ob5 1287 28 . . . cord-006856-b1w25ob5 1288 1 Histopathological Histopathological NNP cord-006856-b1w25ob5 1288 2 examination examination NN cord-006856-b1w25ob5 1288 3 on on IN cord-006856-b1w25ob5 1288 4 po po NNP cord-006856-b1w25ob5 1288 5 day day NNP cord-006856-b1w25ob5 1288 6 10 10 CD cord-006856-b1w25ob5 1288 7 and and CC cord-006856-b1w25ob5 1288 8 30 30 CD cord-006856-b1w25ob5 1288 9 showed show VBD cord-006856-b1w25ob5 1288 10 almost almost RB cord-006856-b1w25ob5 1288 11 normal normal JJ cord-006856-b1w25ob5 1288 12 islet islet NN cord-006856-b1w25ob5 1288 13 cell cell NN cord-006856-b1w25ob5 1288 14 and and CC cord-006856-b1w25ob5 1288 15 acinar acinar NN cord-006856-b1w25ob5 1288 16 architecture architecture NN cord-006856-b1w25ob5 1288 17 of of IN cord-006856-b1w25ob5 1288 18 all all DT cord-006856-b1w25ob5 1288 19 grafts graft NNS cord-006856-b1w25ob5 1288 20 . . . cord-006856-b1w25ob5 1289 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1289 2 . . . cord-006856-b1w25ob5 1290 1 For for IN cord-006856-b1w25ob5 1290 2 the the DT cord-006856-b1w25ob5 1290 3 first first JJ cord-006856-b1w25ob5 1290 4 time time NN cord-006856-b1w25ob5 1290 5 a a DT cord-006856-b1w25ob5 1290 6 method method NN cord-006856-b1w25ob5 1290 7 of of IN cord-006856-b1w25ob5 1290 8 cervical cervical JJ cord-006856-b1w25ob5 1290 9 heterotopic heterotopic NNP cord-006856-b1w25ob5 1290 10 pancreas pancreas NN cord-006856-b1w25ob5 1290 11 transplantation transplantation NN cord-006856-b1w25ob5 1290 12 using use VBG cord-006856-b1w25ob5 1290 13 a a DT cord-006856-b1w25ob5 1290 14 non non JJ cord-006856-b1w25ob5 1290 15 - - JJ cord-006856-b1w25ob5 1290 16 suture suture JJ cord-006856-b1w25ob5 1290 17 cuff cuff NN cord-006856-b1w25ob5 1290 18 technique technique NN cord-006856-b1w25ob5 1290 19 in in IN cord-006856-b1w25ob5 1290 20 the the DT cord-006856-b1w25ob5 1290 21 mouse mouse NN cord-006856-b1w25ob5 1290 22 is be VBZ cord-006856-b1w25ob5 1290 23 described describe VBN cord-006856-b1w25ob5 1290 24 . . . cord-006856-b1w25ob5 1291 1 Major major JJ cord-006856-b1w25ob5 1291 2 advantages advantage NNS cord-006856-b1w25ob5 1291 3 are be VBP cord-006856-b1w25ob5 1291 4 a a DT cord-006856-b1w25ob5 1291 5 short short JJ cord-006856-b1w25ob5 1291 6 ischemia ischemia NN cord-006856-b1w25ob5 1291 7 time time NN cord-006856-b1w25ob5 1291 8 , , , cord-006856-b1w25ob5 1291 9 lack lack NN cord-006856-b1w25ob5 1291 10 of of IN cord-006856-b1w25ob5 1291 11 arterial arterial JJ cord-006856-b1w25ob5 1291 12 thrombosis thrombosis NN cord-006856-b1w25ob5 1291 13 or or CC cord-006856-b1w25ob5 1291 14 venous venous JJ cord-006856-b1w25ob5 1291 15 stenosis stenosis NN cord-006856-b1w25ob5 1291 16 , , , cord-006856-b1w25ob5 1291 17 and and CC cord-006856-b1w25ob5 1291 18 short short JJ cord-006856-b1w25ob5 1291 19 operation operation NN cord-006856-b1w25ob5 1291 20 time time NN cord-006856-b1w25ob5 1291 21 , , , cord-006856-b1w25ob5 1291 22 and and CC cord-006856-b1w25ob5 1291 23 thus thus RB cord-006856-b1w25ob5 1291 24 a a DT cord-006856-b1w25ob5 1291 25 very very RB cord-006856-b1w25ob5 1291 26 high high JJ cord-006856-b1w25ob5 1291 27 survival survival NN cord-006856-b1w25ob5 1291 28 rate rate NN cord-006856-b1w25ob5 1291 29 . . . cord-006856-b1w25ob5 1292 1 This this DT cord-006856-b1w25ob5 1292 2 model model NN cord-006856-b1w25ob5 1292 3 is be VBZ cord-006856-b1w25ob5 1292 4 especially especially RB cord-006856-b1w25ob5 1292 5 applicable applicable JJ cord-006856-b1w25ob5 1292 6 for for IN cord-006856-b1w25ob5 1292 7 investigating investigate VBG cord-006856-b1w25ob5 1292 8 preservation preservation NN cord-006856-b1w25ob5 1292 9 , , , cord-006856-b1w25ob5 1292 10 reperfusion reperfusion NN cord-006856-b1w25ob5 1292 11 injury injury NN cord-006856-b1w25ob5 1292 12 , , , cord-006856-b1w25ob5 1292 13 and and CC cord-006856-b1w25ob5 1292 14 graft graft NN cord-006856-b1w25ob5 1292 15 pancreatitis pancreatitis NN cord-006856-b1w25ob5 1292 16 . . . cord-006856-b1w25ob5 1293 1 Background background NN cord-006856-b1w25ob5 1293 2 . . . cord-006856-b1w25ob5 1294 1 As as IN cord-006856-b1w25ob5 1294 2 human human JJ cord-006856-b1w25ob5 1294 3 islet islet NN cord-006856-b1w25ob5 1294 4 transplantation transplantation NN cord-006856-b1w25ob5 1294 5 is be VBZ cord-006856-b1w25ob5 1294 6 limited limit VBN cord-006856-b1w25ob5 1294 7 by by IN cord-006856-b1w25ob5 1294 8 the the DT cord-006856-b1w25ob5 1294 9 lack lack NN cord-006856-b1w25ob5 1294 10 of of IN cord-006856-b1w25ob5 1294 11 sufficient sufficient JJ cord-006856-b1w25ob5 1294 12 numbers number NNS cord-006856-b1w25ob5 1294 13 of of IN cord-006856-b1w25ob5 1294 14 human human JJ cord-006856-b1w25ob5 1294 15 donor donor NN cord-006856-b1w25ob5 1294 16 organs organ NNS cord-006856-b1w25ob5 1294 17 , , , cord-006856-b1w25ob5 1294 18 xenotransplantation xenotransplantation NN cord-006856-b1w25ob5 1294 19 with with IN cord-006856-b1w25ob5 1294 20 the the DT cord-006856-b1w25ob5 1294 21 use use NN cord-006856-b1w25ob5 1294 22 of of IN cord-006856-b1w25ob5 1294 23 porcine porcine JJ cord-006856-b1w25ob5 1294 24 islet islet NN cord-006856-b1w25ob5 1294 25 cells cell NNS cord-006856-b1w25ob5 1294 26 seems seem VBZ cord-006856-b1w25ob5 1294 27 to to TO cord-006856-b1w25ob5 1294 28 be be VB cord-006856-b1w25ob5 1294 29 a a DT cord-006856-b1w25ob5 1294 30 promising promising JJ cord-006856-b1w25ob5 1294 31 therapeutic therapeutic JJ cord-006856-b1w25ob5 1294 32 option option NN cord-006856-b1w25ob5 1294 33 to to TO cord-006856-b1w25ob5 1294 34 cure cure VB cord-006856-b1w25ob5 1294 35 diabetes diabetes NN cord-006856-b1w25ob5 1294 36 . . . cord-006856-b1w25ob5 1295 1 In in IN cord-006856-b1w25ob5 1295 2 order order NN cord-006856-b1w25ob5 1295 3 to to TO cord-006856-b1w25ob5 1295 4 achieve achieve VB cord-006856-b1w25ob5 1295 5 sufficient sufficient JJ cord-006856-b1w25ob5 1295 6 numbers number NNS cord-006856-b1w25ob5 1295 7 of of IN cord-006856-b1w25ob5 1295 8 viable viable JJ cord-006856-b1w25ob5 1295 9 islet islet NN cord-006856-b1w25ob5 1295 10 cells cell NNS cord-006856-b1w25ob5 1295 11 , , , cord-006856-b1w25ob5 1295 12 better well JJR cord-006856-b1w25ob5 1295 13 protocols protocol NNS cord-006856-b1w25ob5 1295 14 for for IN cord-006856-b1w25ob5 1295 15 organ organ NN cord-006856-b1w25ob5 1295 16 preservation preservation NN cord-006856-b1w25ob5 1295 17 , , , cord-006856-b1w25ob5 1295 18 isolation isolation NN cord-006856-b1w25ob5 1295 19 , , , cord-006856-b1w25ob5 1295 20 and and CC cord-006856-b1w25ob5 1295 21 purification purification NN cord-006856-b1w25ob5 1295 22 are be VBP cord-006856-b1w25ob5 1295 23 needed need VBN cord-006856-b1w25ob5 1295 24 . . . cord-006856-b1w25ob5 1296 1 Recent recent JJ cord-006856-b1w25ob5 1296 2 studies study NNS cord-006856-b1w25ob5 1296 3 showed show VBD cord-006856-b1w25ob5 1296 4 that that IN cord-006856-b1w25ob5 1296 5 the the DT cord-006856-b1w25ob5 1296 6 two two CD cord-006856-b1w25ob5 1296 7 - - HYPH cord-006856-b1w25ob5 1296 8 layer layer NN cord-006856-b1w25ob5 1296 9 method method NN cord-006856-b1w25ob5 1296 10 ( ( -LRB- cord-006856-b1w25ob5 1296 11 TLM TLM NNP cord-006856-b1w25ob5 1296 12 ) ) -RRB- cord-006856-b1w25ob5 1296 13 of of IN cord-006856-b1w25ob5 1296 14 pancreas pancreas NN cord-006856-b1w25ob5 1296 15 preservation preservation NN cord-006856-b1w25ob5 1296 16 prior prior RB cord-006856-b1w25ob5 1296 17 to to IN cord-006856-b1w25ob5 1296 18 isolation isolation NN cord-006856-b1w25ob5 1296 19 significantly significantly RB cord-006856-b1w25ob5 1296 20 improved improve VBN cord-006856-b1w25ob5 1296 21 islet islet NN cord-006856-b1w25ob5 1296 22 yield yield NN cord-006856-b1w25ob5 1296 23 . . . cord-006856-b1w25ob5 1297 1 The the DT cord-006856-b1w25ob5 1297 2 TLM TLM NNP cord-006856-b1w25ob5 1297 3 oxygenates oxygenate VBZ cord-006856-b1w25ob5 1297 4 pancreata pancreata NN cord-006856-b1w25ob5 1297 5 and and CC cord-006856-b1w25ob5 1297 6 activates activate VBZ cord-006856-b1w25ob5 1297 7 metabolism metabolism NN cord-006856-b1w25ob5 1297 8 to to TO cord-006856-b1w25ob5 1297 9 generate generate VB cord-006856-b1w25ob5 1297 10 ATP ATP NNP cord-006856-b1w25ob5 1297 11 and and CC cord-006856-b1w25ob5 1297 12 leads lead VBZ cord-006856-b1w25ob5 1297 13 to to IN cord-006856-b1w25ob5 1297 14 resuscitation resuscitation NN cord-006856-b1w25ob5 1297 15 of of IN cord-006856-b1w25ob5 1297 16 ischemically ischemically RB cord-006856-b1w25ob5 1297 17 damaged damage VBN cord-006856-b1w25ob5 1297 18 organs organ NNS cord-006856-b1w25ob5 1297 19 . . . cord-006856-b1w25ob5 1298 1 Another another DT cord-006856-b1w25ob5 1298 2 possibility possibility NN cord-006856-b1w25ob5 1298 3 to to TO cord-006856-b1w25ob5 1298 4 achieve achieve VB cord-006856-b1w25ob5 1298 5 a a DT cord-006856-b1w25ob5 1298 6 higher high JJR cord-006856-b1w25ob5 1298 7 partial partial JJ cord-006856-b1w25ob5 1298 8 pressure pressure NN cord-006856-b1w25ob5 1298 9 of of IN cord-006856-b1w25ob5 1298 10 oxygen oxygen NN cord-006856-b1w25ob5 1298 11 levels level NNS cord-006856-b1w25ob5 1298 12 in in IN cord-006856-b1w25ob5 1298 13 fluids fluid NNS cord-006856-b1w25ob5 1298 14 is be VBZ cord-006856-b1w25ob5 1298 15 the the DT cord-006856-b1w25ob5 1298 16 use use NN cord-006856-b1w25ob5 1298 17 of of IN cord-006856-b1w25ob5 1298 18 hyperbaric hyperbaric NN cord-006856-b1w25ob5 1298 19 oxygenation oxygenation NN cord-006856-b1w25ob5 1298 20 ( ( -LRB- cord-006856-b1w25ob5 1298 21 HBO HBO NNP cord-006856-b1w25ob5 1298 22 ) ) -RRB- cord-006856-b1w25ob5 1298 23 . . . cord-006856-b1w25ob5 1299 1 The the DT cord-006856-b1w25ob5 1299 2 aim aim NN cord-006856-b1w25ob5 1299 3 of of IN cord-006856-b1w25ob5 1299 4 this this DT cord-006856-b1w25ob5 1299 5 study study NN cord-006856-b1w25ob5 1299 6 was be VBD cord-006856-b1w25ob5 1299 7 to to TO cord-006856-b1w25ob5 1299 8 assess assess VB cord-006856-b1w25ob5 1299 9 the the DT cord-006856-b1w25ob5 1299 10 influence influence NN cord-006856-b1w25ob5 1299 11 of of IN cord-006856-b1w25ob5 1299 12 preoxygenated preoxygenated JJ cord-006856-b1w25ob5 1299 13 preservation preservation NN cord-006856-b1w25ob5 1299 14 solutions solution NNS cord-006856-b1w25ob5 1299 15 on on IN cord-006856-b1w25ob5 1299 16 the the DT cord-006856-b1w25ob5 1299 17 porcine porcine JJ cord-006856-b1w25ob5 1299 18 pancreas pancreas NN cord-006856-b1w25ob5 1299 19 . . . cord-006856-b1w25ob5 1300 1 Methods method NNS cord-006856-b1w25ob5 1300 2 . . . cord-006856-b1w25ob5 1301 1 University University NNP cord-006856-b1w25ob5 1301 2 of of IN cord-006856-b1w25ob5 1301 3 Wisconsin Wisconsin NNP cord-006856-b1w25ob5 1301 4 solution solution NN cord-006856-b1w25ob5 1301 5 ( ( -LRB- cord-006856-b1w25ob5 1301 6 UW UW NNP cord-006856-b1w25ob5 1301 7 ) ) -RRB- cord-006856-b1w25ob5 1301 8 , , , cord-006856-b1w25ob5 1301 9 Celsior Celsior NNP cord-006856-b1w25ob5 1301 10 , , , cord-006856-b1w25ob5 1301 11 Perfadex Perfadex NNP cord-006856-b1w25ob5 1301 12 , , , cord-006856-b1w25ob5 1301 13 Custodiol Custodiol NNP cord-006856-b1w25ob5 1301 14 , , , cord-006856-b1w25ob5 1301 15 and and CC cord-006856-b1w25ob5 1301 16 a a DT cord-006856-b1w25ob5 1301 17 preservation preservation NN cord-006856-b1w25ob5 1301 18 solution solution NN cord-006856-b1w25ob5 1301 19 especially especially RB cord-006856-b1w25ob5 1301 20 designed design VBN cord-006856-b1w25ob5 1301 21 for for IN cord-006856-b1w25ob5 1301 22 this this DT cord-006856-b1w25ob5 1301 23 study study NN cord-006856-b1w25ob5 1301 24 on on IN cord-006856-b1w25ob5 1301 25 the the DT cord-006856-b1w25ob5 1301 26 basis basis NN cord-006856-b1w25ob5 1301 27 of of IN cord-006856-b1w25ob5 1301 28 ketoglutarate ketoglutarate NNP cord-006856-b1w25ob5 1301 29 are be VBP cord-006856-b1w25ob5 1301 30 oxygenated oxygenated JJ cord-006856-b1w25ob5 1301 31 with with IN cord-006856-b1w25ob5 1301 32 100 100 CD cord-006856-b1w25ob5 1301 33 % % NN cord-006856-b1w25ob5 1301 34 oxygen oxygen NN cord-006856-b1w25ob5 1301 35 for for IN cord-006856-b1w25ob5 1301 36 50 50 CD cord-006856-b1w25ob5 1301 37 minutes minute NNS cord-006856-b1w25ob5 1301 38 at at IN cord-006856-b1w25ob5 1301 39 1.5 1.5 CD cord-006856-b1w25ob5 1301 40 bar bar NN cord-006856-b1w25ob5 1301 41 using use VBG cord-006856-b1w25ob5 1301 42 a a DT cord-006856-b1w25ob5 1301 43 hyperbaric hyperbaric NN cord-006856-b1w25ob5 1301 44 chamber chamber NN cord-006856-b1w25ob5 1301 45 . . . cord-006856-b1w25ob5 1302 1 Porcine porcine JJ cord-006856-b1w25ob5 1302 2 pancreata pancreata NN cord-006856-b1w25ob5 1302 3 are be VBP cord-006856-b1w25ob5 1302 4 harvested harvest VBN cord-006856-b1w25ob5 1302 5 at at IN cord-006856-b1w25ob5 1302 6 a a DT cord-006856-b1w25ob5 1302 7 local local JJ cord-006856-b1w25ob5 1302 8 slaughter slaughter NN cord-006856-b1w25ob5 1302 9 house house NN cord-006856-b1w25ob5 1302 10 and and CC cord-006856-b1w25ob5 1302 11 stored store VBN cord-006856-b1w25ob5 1302 12 in in IN cord-006856-b1w25ob5 1302 13 preoxygenated preoxygenated JJ cord-006856-b1w25ob5 1302 14 and and CC cord-006856-b1w25ob5 1302 15 not not RB cord-006856-b1w25ob5 1302 16 oxygenated oxygenated JJ cord-006856-b1w25ob5 1302 17 preservation preservation NN cord-006856-b1w25ob5 1302 18 solutions solution NNS cord-006856-b1w25ob5 1302 19 at at IN cord-006856-b1w25ob5 1302 20 4 4 CD cord-006856-b1w25ob5 1302 21 ° ° NN cord-006856-b1w25ob5 1302 22 C c NN cord-006856-b1w25ob5 1302 23 for for IN cord-006856-b1w25ob5 1302 24 4 4 CD cord-006856-b1w25ob5 1302 25 hours hour NNS cord-006856-b1w25ob5 1302 26 . . . cord-006856-b1w25ob5 1303 1 Tissue tissue NN cord-006856-b1w25ob5 1303 2 cuts cut NNS cord-006856-b1w25ob5 1303 3 are be VBP cord-006856-b1w25ob5 1303 4 performed perform VBN cord-006856-b1w25ob5 1303 5 to to TO cord-006856-b1w25ob5 1303 6 assess assess VB cord-006856-b1w25ob5 1303 7 the the DT cord-006856-b1w25ob5 1303 8 occurrence occurrence NN cord-006856-b1w25ob5 1303 9 of of IN cord-006856-b1w25ob5 1303 10 apoptosis apoptosis NN cord-006856-b1w25ob5 1303 11 and and CC cord-006856-b1w25ob5 1303 12 to to TO cord-006856-b1w25ob5 1303 13 determine determine VB cord-006856-b1w25ob5 1303 14 the the DT cord-006856-b1w25ob5 1303 15 oxidative oxidative JJ cord-006856-b1w25ob5 1303 16 stress stress NN cord-006856-b1w25ob5 1303 17 . . . cord-006856-b1w25ob5 1304 1 ATP ATP NNP cord-006856-b1w25ob5 1304 2 - - HYPH cord-006856-b1w25ob5 1304 3 to to IN cord-006856-b1w25ob5 1304 4 - - HYPH cord-006856-b1w25ob5 1304 5 ADP adp NN cord-006856-b1w25ob5 1304 6 ratio ratio NN cord-006856-b1w25ob5 1304 7 is be VBZ cord-006856-b1w25ob5 1304 8 measured measure VBN cord-006856-b1w25ob5 1304 9 and and CC cord-006856-b1w25ob5 1304 10 immunohistochemistry immunohistochemistry NN cord-006856-b1w25ob5 1304 11 is be VBZ cord-006856-b1w25ob5 1304 12 performed perform VBN cord-006856-b1w25ob5 1304 13 . . . cord-006856-b1w25ob5 1305 1 Results result NNS cord-006856-b1w25ob5 1305 2 . . . cord-006856-b1w25ob5 1306 1 It -PRON- PRP cord-006856-b1w25ob5 1306 2 is be VBZ cord-006856-b1w25ob5 1306 3 feasible feasible JJ cord-006856-b1w25ob5 1306 4 to to TO cord-006856-b1w25ob5 1306 5 preoxygenate preoxygenate VB cord-006856-b1w25ob5 1306 6 preservation preservation NN cord-006856-b1w25ob5 1306 7 solutions solution NNS cord-006856-b1w25ob5 1306 8 . . . cord-006856-b1w25ob5 1307 1 The the DT cord-006856-b1w25ob5 1307 2 oxygen oxygen NN cord-006856-b1w25ob5 1307 3 levels level NNS cord-006856-b1w25ob5 1307 4 can can MD cord-006856-b1w25ob5 1307 5 be be VB cord-006856-b1w25ob5 1307 6 raised raise VBN cord-006856-b1w25ob5 1307 7 up up RP cord-006856-b1w25ob5 1307 8 to to TO cord-006856-b1w25ob5 1307 9 100 100 CD cord-006856-b1w25ob5 1307 10 times time NNS cord-006856-b1w25ob5 1307 11 in in IN cord-006856-b1w25ob5 1307 12 the the DT cord-006856-b1w25ob5 1307 13 preservation preservation NN cord-006856-b1w25ob5 1307 14 solutions solution NNS cord-006856-b1w25ob5 1307 15 using use VBG cord-006856-b1w25ob5 1307 16 HBO HBO NNP cord-006856-b1w25ob5 1307 17 and and CC cord-006856-b1w25ob5 1307 18 can can MD cord-006856-b1w25ob5 1307 19 be be VB cord-006856-b1w25ob5 1307 20 maintained maintain VBN cord-006856-b1w25ob5 1307 21 for for IN cord-006856-b1w25ob5 1307 22 at at RB cord-006856-b1w25ob5 1307 23 least least RBS cord-006856-b1w25ob5 1307 24 12 12 CD cord-006856-b1w25ob5 1307 25 hours hour NNS cord-006856-b1w25ob5 1307 26 after after IN cord-006856-b1w25ob5 1307 27 HBO HBO NNP cord-006856-b1w25ob5 1307 28 treatment treatment NN cord-006856-b1w25ob5 1307 29 . . . cord-006856-b1w25ob5 1308 1 MDA MDA NNP cord-006856-b1w25ob5 1308 2 and and CC cord-006856-b1w25ob5 1308 3 carbonylated carbonylate VBD cord-006856-b1w25ob5 1308 4 protein protein NN cord-006856-b1w25ob5 1308 5 levels level NNS cord-006856-b1w25ob5 1308 6 are be VBP cord-006856-b1w25ob5 1308 7 not not RB cord-006856-b1w25ob5 1308 8 significantly significantly RB cord-006856-b1w25ob5 1308 9 elevated elevate VBN cord-006856-b1w25ob5 1308 10 in in IN cord-006856-b1w25ob5 1308 11 organs organ NNS cord-006856-b1w25ob5 1308 12 stored store VBN cord-006856-b1w25ob5 1308 13 in in IN cord-006856-b1w25ob5 1308 14 preoxygenated preoxygenated JJ cord-006856-b1w25ob5 1308 15 solutions solution NNS cord-006856-b1w25ob5 1308 16 . . . cord-006856-b1w25ob5 1309 1 ATP ATP NNP cord-006856-b1w25ob5 1309 2 - - HYPH cord-006856-b1w25ob5 1309 3 to to IN cord-006856-b1w25ob5 1309 4 - - HYPH cord-006856-b1w25ob5 1309 5 ADP adp NN cord-006856-b1w25ob5 1309 6 ratio ratio NN cord-006856-b1w25ob5 1309 7 as as IN cord-006856-b1w25ob5 1309 8 a a DT cord-006856-b1w25ob5 1309 9 sign sign NN cord-006856-b1w25ob5 1309 10 of of IN cord-006856-b1w25ob5 1309 11 viability viability NN cord-006856-b1w25ob5 1309 12 is be VBZ cord-006856-b1w25ob5 1309 13 significantly significantly RB cord-006856-b1w25ob5 1309 14 higher high JJR cord-006856-b1w25ob5 1309 15 in in IN cord-006856-b1w25ob5 1309 16 organs organ NNS cord-006856-b1w25ob5 1309 17 stored store VBN cord-006856-b1w25ob5 1309 18 in in IN cord-006856-b1w25ob5 1309 19 preoxygenated preoxygenated JJ cord-006856-b1w25ob5 1309 20 solutions solution NNS cord-006856-b1w25ob5 1309 21 . . . cord-006856-b1w25ob5 1310 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1310 2 . . . cord-006856-b1w25ob5 1311 1 Preoxygenation preoxygenation NN cord-006856-b1w25ob5 1311 2 of of IN cord-006856-b1w25ob5 1311 3 preservation preservation NN cord-006856-b1w25ob5 1311 4 solutions solution NNS cord-006856-b1w25ob5 1311 5 using use VBG cord-006856-b1w25ob5 1311 6 100 100 CD cord-006856-b1w25ob5 1311 7 % % NN cord-006856-b1w25ob5 1311 8 oxygen oxygen NN cord-006856-b1w25ob5 1311 9 and and CC cord-006856-b1w25ob5 1311 10 a a DT cord-006856-b1w25ob5 1311 11 hyperbaric hyperbaric NN cord-006856-b1w25ob5 1311 12 chamber chamber NN cord-006856-b1w25ob5 1311 13 is be VBZ cord-006856-b1w25ob5 1311 14 feasible feasible JJ cord-006856-b1w25ob5 1311 15 . . . cord-006856-b1w25ob5 1312 1 HBO HBO NNP cord-006856-b1w25ob5 1312 2 has have VBZ cord-006856-b1w25ob5 1312 3 a a DT cord-006856-b1w25ob5 1312 4 positive positive JJ cord-006856-b1w25ob5 1312 5 impact impact NN cord-006856-b1w25ob5 1312 6 on on IN cord-006856-b1w25ob5 1312 7 porcine porcine JJ cord-006856-b1w25ob5 1312 8 organ organ NN cord-006856-b1w25ob5 1312 9 preservation preservation NN cord-006856-b1w25ob5 1312 10 . . . cord-006856-b1w25ob5 1313 1 As as IN cord-006856-b1w25ob5 1313 2 ischemically ischemically RB cord-006856-b1w25ob5 1313 3 damaged damage VBN cord-006856-b1w25ob5 1313 4 islet islet NN cord-006856-b1w25ob5 1313 5 cells cell NNS cord-006856-b1w25ob5 1313 6 are be VBP cord-006856-b1w25ob5 1313 7 likely likely JJ cord-006856-b1w25ob5 1313 8 to to TO cord-006856-b1w25ob5 1313 9 undergo undergo VB cord-006856-b1w25ob5 1313 10 cell cell NN cord-006856-b1w25ob5 1313 11 death death NN cord-006856-b1w25ob5 1313 12 or or CC cord-006856-b1w25ob5 1313 13 lose lose VB cord-006856-b1w25ob5 1313 14 functionality functionality NN cord-006856-b1w25ob5 1313 15 due due IN cord-006856-b1w25ob5 1313 16 to to IN cord-006856-b1w25ob5 1313 17 hypoxia hypoxia NN cord-006856-b1w25ob5 1313 18 , , , cord-006856-b1w25ob5 1313 19 the the DT cord-006856-b1w25ob5 1313 20 use use NN cord-006856-b1w25ob5 1313 21 of of IN cord-006856-b1w25ob5 1313 22 preoxygenated preoxygenated JJ cord-006856-b1w25ob5 1313 23 preservation preservation NN cord-006856-b1w25ob5 1313 24 solutions solution NNS cord-006856-b1w25ob5 1313 25 is be VBZ cord-006856-b1w25ob5 1313 26 a a DT cord-006856-b1w25ob5 1313 27 promising promising JJ cord-006856-b1w25ob5 1313 28 method method NN cord-006856-b1w25ob5 1313 29 to to TO cord-006856-b1w25ob5 1313 30 achieve achieve VB cord-006856-b1w25ob5 1313 31 better well JJR cord-006856-b1w25ob5 1313 32 yields yield NNS cord-006856-b1w25ob5 1313 33 after after IN cord-006856-b1w25ob5 1313 34 islet islet NN cord-006856-b1w25ob5 1313 35 isolation isolation NN cord-006856-b1w25ob5 1313 36 and and CC cord-006856-b1w25ob5 1313 37 transplantation transplantation NN cord-006856-b1w25ob5 1313 38 . . . cord-006856-b1w25ob5 1314 1 Alternative alternative JJ cord-006856-b1w25ob5 1314 2 zur zur NNP cord-006856-b1w25ob5 1314 3 humanen humanen NNP cord-006856-b1w25ob5 1314 4 Pankreastransplantation Pankreastransplantation NNP cord-006856-b1w25ob5 1314 5 und und IN cord-006856-b1w25ob5 1314 6 Inselzelltransplantation Inselzelltransplantation NNP cord-006856-b1w25ob5 1314 7 stellt stellt NNP cord-006856-b1w25ob5 1314 8 die die VB cord-006856-b1w25ob5 1315 1 Xenotransplantation xenotransplantation NN cord-006856-b1w25ob5 1315 2 von von NNP cord-006856-b1w25ob5 1315 3 porcinen porcinen JJ cord-006856-b1w25ob5 1315 4 Inselzellen Inselzellen NNP cord-006856-b1w25ob5 1315 5 dar dar NNP cord-006856-b1w25ob5 1315 6 . . . cord-006856-b1w25ob5 1316 1 Um um UH cord-006856-b1w25ob5 1316 2 xenogene xenogene NNP cord-006856-b1w25ob5 1316 3 Zellen Zellen NNP cord-006856-b1w25ob5 1316 4 erfolgreich erfolgreich NNP cord-006856-b1w25ob5 1317 1 transplantieren transplantieren NNP cord-006856-b1w25ob5 1317 2 zu zu NNP cord-006856-b1w25ob5 1317 3 können können NNP cord-006856-b1w25ob5 1317 4 , , , cord-006856-b1w25ob5 1317 5 müssen müssen NNP cord-006856-b1w25ob5 1317 6 sie sie NNP cord-006856-b1w25ob5 1317 7 vom vom NNP cord-006856-b1w25ob5 1318 1 Immunsystem Immunsystem NNP cord-006856-b1w25ob5 1318 2 des des NNP cord-006856-b1w25ob5 1318 3 Empfängers Empfängers NNP cord-006856-b1w25ob5 1318 4 abgeschirmt abgeschirmt NN cord-006856-b1w25ob5 1318 5 werden werden NNP cord-006856-b1w25ob5 1318 6 . . . cord-006856-b1w25ob5 1319 1 Die die VB cord-006856-b1w25ob5 1319 2 Verwendung Verwendung NNP cord-006856-b1w25ob5 1319 3 von von NNP cord-006856-b1w25ob5 1319 4 Mikrokapseln Mikrokapseln NNP cord-006856-b1w25ob5 1319 5 scheint scheint NNP cord-006856-b1w25ob5 1320 1 eine eine NNP cord-006856-b1w25ob5 1320 2 vielversprechende vielversprechende NNP cord-006856-b1w25ob5 1320 3 Methode Methode NNP cord-006856-b1w25ob5 1320 4 dazu dazu FW cord-006856-b1w25ob5 1320 5 zu zu NNP cord-006856-b1w25ob5 1320 6 sein sein NNP cord-006856-b1w25ob5 1320 7 , , , cord-006856-b1w25ob5 1320 8 wobei wobei NNP cord-006856-b1w25ob5 1320 9 Natrium Natrium NNP cord-006856-b1w25ob5 1320 10 Zellulose Zellulose NNP cord-006856-b1w25ob5 1320 11 Sulfat Sulfat NNP cord-006856-b1w25ob5 1320 12 ( ( -LRB- cord-006856-b1w25ob5 1320 13 NaCS NaCS NNP cord-006856-b1w25ob5 1320 14 ) ) -RRB- cord-006856-b1w25ob5 1320 15 in in IN cord-006856-b1w25ob5 1320 16 Graz Graz NNP cord-006856-b1w25ob5 1320 17 verwendet verwendet NNP cord-006856-b1w25ob5 1320 18 wird wird NNP cord-006856-b1w25ob5 1320 19 . . . cord-006856-b1w25ob5 1321 1 Darüber Darüber NNP cord-006856-b1w25ob5 1321 2 hinaus hinaus NNP cord-006856-b1w25ob5 1321 3 muss muss NNP cord-006856-b1w25ob5 1321 4 eine eine NNP cord-006856-b1w25ob5 1321 5 ausreichende ausreichende NNP cord-006856-b1w25ob5 1321 6 Anzahl Anzahl NNP cord-006856-b1w25ob5 1322 1 an an DT cord-006856-b1w25ob5 1322 2 vitalen vitalen NN cord-006856-b1w25ob5 1322 3 Zellen Zellen NNP cord-006856-b1w25ob5 1322 4 mit mit NN cord-006856-b1w25ob5 1322 5 hoher hoher NNP cord-006856-b1w25ob5 1322 6 Reinheit Reinheit NNP cord-006856-b1w25ob5 1322 7 aus aus NNP cord-006856-b1w25ob5 1322 8 dem dem NNP cord-006856-b1w25ob5 1322 9 porcinen porcinen NNP cord-006856-b1w25ob5 1322 10 Pankreas Pankreas NNP cord-006856-b1w25ob5 1322 11 isoliert isoliert NNP cord-006856-b1w25ob5 1323 1 werden werden NNP cord-006856-b1w25ob5 1323 2 . . . cord-006856-b1w25ob5 1324 1 Methodik Methodik NNP cord-006856-b1w25ob5 1324 2 . . . cord-006856-b1w25ob5 1325 1 Porcine Porcine NNP cord-006856-b1w25ob5 1325 2 Pankreata Pankreata NNP cord-006856-b1w25ob5 1325 3 werden werden NNP cord-006856-b1w25ob5 1325 4 von von NNP cord-006856-b1w25ob5 1325 5 einem einem NNP cord-006856-b1w25ob5 1325 6 lokalen lokalen NNP cord-006856-b1w25ob5 1325 7 Schlachthof Schlachthof NNP cord-006856-b1w25ob5 1325 8 erhalten erhalten NNP cord-006856-b1w25ob5 1325 9 . . . cord-006856-b1w25ob5 1326 1 Die Die NNP cord-006856-b1w25ob5 1326 2 Organe Organe NNP cord-006856-b1w25ob5 1326 3 werden werden NNP cord-006856-b1w25ob5 1326 4 kanüliert kanüliert NNP cord-006856-b1w25ob5 1326 5 , , , cord-006856-b1w25ob5 1327 1 und und IN cord-006856-b1w25ob5 1327 2 ein ein NNP cord-006856-b1w25ob5 1327 3 Enzymgemisch Enzymgemisch NNP cord-006856-b1w25ob5 1327 4 aus aus NNP cord-006856-b1w25ob5 1327 5 neutraler neutraler NN cord-006856-b1w25ob5 1327 6 Protease Protease NNP cord-006856-b1w25ob5 1327 7 und und IN cord-006856-b1w25ob5 1327 8 Kollagenase Kollagenase NNP cord-006856-b1w25ob5 1327 9 NB NB NNP cord-006856-b1w25ob5 1327 10 wird wird NNP cord-006856-b1w25ob5 1327 11 infundiert infundiert NNP cord-006856-b1w25ob5 1327 12 . . . cord-006856-b1w25ob5 1328 1 Die die VB cord-006856-b1w25ob5 1328 2 Digestion digestion NN cord-006856-b1w25ob5 1328 3 erfolgt erfolgt NN cord-006856-b1w25ob5 1328 4 in in IN cord-006856-b1w25ob5 1328 5 einer einer JJ cord-006856-b1w25ob5 1328 6 modifizierten modifizierten NNP cord-006856-b1w25ob5 1328 7 Ricordi Ricordi NNP cord-006856-b1w25ob5 1328 8 - - HYPH cord-006856-b1w25ob5 1328 9 Kammer Kammer NNP cord-006856-b1w25ob5 1328 10 mechanisch mechanisch NNP cord-006856-b1w25ob5 1328 11 und und IN cord-006856-b1w25ob5 1328 12 enzymatisch enzymatisch NNP cord-006856-b1w25ob5 1328 13 , , , cord-006856-b1w25ob5 1328 14 und und RB cord-006856-b1w25ob5 1328 15 die die VBP cord-006856-b1w25ob5 1328 16 anschließende anschließende NNP cord-006856-b1w25ob5 1328 17 Purifikation Purifikation NNP cord-006856-b1w25ob5 1328 18 wird wird NNP cord-006856-b1w25ob5 1328 19 mit mit NNP cord-006856-b1w25ob5 1328 20 einem einem NNP cord-006856-b1w25ob5 1328 21 Ficoll Ficoll NNP cord-006856-b1w25ob5 1328 22 - - HYPH cord-006856-b1w25ob5 1328 23 Dichtegradienten Dichtegradienten NNP cord-006856-b1w25ob5 1328 24 durchgeführt durchgeführt NN cord-006856-b1w25ob5 1328 25 . . . cord-006856-b1w25ob5 1329 1 Vitalität Vitalität NNP cord-006856-b1w25ob5 1329 2 der der NNP cord-006856-b1w25ob5 1329 3 Zellen Zellen NNP cord-006856-b1w25ob5 1329 4 wird wird NNP cord-006856-b1w25ob5 1329 5 mit mit NNP cord-006856-b1w25ob5 1329 6 Fluorescein Fluorescein NNP cord-006856-b1w25ob5 1329 7 - - HYPH cord-006856-b1w25ob5 1329 8 Diacetat Diacetat NNP cord-006856-b1w25ob5 1329 9 / / SYM cord-006856-b1w25ob5 1329 10 Propidium Propidium NNP cord-006856-b1w25ob5 1329 11 Jodid Jodid NNP cord-006856-b1w25ob5 1329 12 , , , cord-006856-b1w25ob5 1329 13 MTT MTT NNP cord-006856-b1w25ob5 1329 14 und und NNP cord-006856-b1w25ob5 1329 15 der der NNP cord-006856-b1w25ob5 1329 16 Bestimmung Bestimmung NNP cord-006856-b1w25ob5 1329 17 der der NNP cord-006856-b1w25ob5 1329 18 ATP ATP NNP cord-006856-b1w25ob5 1329 19 / / SYM cord-006856-b1w25ob5 1329 20 ADP ADP NNP cord-006856-b1w25ob5 1329 21 - - HYPH cord-006856-b1w25ob5 1329 22 Ratio Ratio NNP cord-006856-b1w25ob5 1329 23 überprüft überprüft NN cord-006856-b1w25ob5 1329 24 . . . cord-006856-b1w25ob5 1330 1 Die die VB cord-006856-b1w25ob5 1330 2 Reinheit Reinheit NNP cord-006856-b1w25ob5 1330 3 wird wird NNP cord-006856-b1w25ob5 1330 4 mit mit NNP cord-006856-b1w25ob5 1330 5 einer einer NNP cord-006856-b1w25ob5 1330 6 Dithizon Dithizon NNP cord-006856-b1w25ob5 1330 7 - - HYPH cord-006856-b1w25ob5 1330 8 Färbung Färbung NNP cord-006856-b1w25ob5 1330 9 festgestellt festgestellt NN cord-006856-b1w25ob5 1330 10 . . . cord-006856-b1w25ob5 1331 1 Insulinkonzentrationen Insulinkonzentrationen NNP cord-006856-b1w25ob5 1331 2 werden werden NNP cord-006856-b1w25ob5 1331 3 mittels mittels NNP cord-006856-b1w25ob5 1331 4 ELISA ELISA NNP cord-006856-b1w25ob5 1331 5 detektiert detektiert NNP cord-006856-b1w25ob5 1331 6 , , , cord-006856-b1w25ob5 1331 7 der der NNP cord-006856-b1w25ob5 1331 8 DNA DNA NNP cord-006856-b1w25ob5 1331 9 - - HYPH cord-006856-b1w25ob5 1331 10 Gehalt Gehalt NNP cord-006856-b1w25ob5 1331 11 der der NN cord-006856-b1w25ob5 1331 12 Inselzellen Inselzellen NNP cord-006856-b1w25ob5 1331 13 mit mit NNP cord-006856-b1w25ob5 1331 14 dem dem NNP cord-006856-b1w25ob5 1331 15 DNEasy DNEasy NNP cord-006856-b1w25ob5 1331 16 - - HYPH cord-006856-b1w25ob5 1331 17 Kit kit NN cord-006856-b1w25ob5 1331 18 festgestellt festgestellt NNS cord-006856-b1w25ob5 1331 19 . . . cord-006856-b1w25ob5 1332 1 Inselzellen Inselzellen NNP cord-006856-b1w25ob5 1332 2 werden werden NNP cord-006856-b1w25ob5 1332 3 in in IN cord-006856-b1w25ob5 1332 4 Kooperation Kooperation NNP cord-006856-b1w25ob5 1332 5 mit mit NNP cord-006856-b1w25ob5 1332 6 der der NNP cord-006856-b1w25ob5 1332 7 Firma Firma NNP cord-006856-b1w25ob5 1332 8 Austrianova Austrianova NNP cord-006856-b1w25ob5 1332 9 mit mit NNP cord-006856-b1w25ob5 1332 10 NaCS NaCS NNP cord-006856-b1w25ob5 1332 11 mikroverkapselt mikroverkapselt NNP cord-006856-b1w25ob5 1332 12 . . . cord-006856-b1w25ob5 1333 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 1333 2 . . . cord-006856-b1w25ob5 1334 1 Die Die NNP cord-006856-b1w25ob5 1334 2 Organe Organe NNP cord-006856-b1w25ob5 1334 3 wurden wurden VBD cord-006856-b1w25ob5 1334 4 durchschnittlich durchschnittlich NNP cord-006856-b1w25ob5 1334 5 35 35 CD cord-006856-b1w25ob5 1334 6 min min NNP cord-006856-b1w25ob5 1334 7 digestiert digestiert NNP cord-006856-b1w25ob5 1334 8 , , , cord-006856-b1w25ob5 1334 9 es es NNP cord-006856-b1w25ob5 1334 10 wurde wurde NNP cord-006856-b1w25ob5 1335 1 eine eine NNP cord-006856-b1w25ob5 1335 2 Reinheit Reinheit NNP cord-006856-b1w25ob5 1335 3 von von NNP cord-006856-b1w25ob5 1336 1 96 96 CD cord-006856-b1w25ob5 1336 2 % % NN cord-006856-b1w25ob5 1336 3 und und NNP cord-006856-b1w25ob5 1336 4 eine eine NNP cord-006856-b1w25ob5 1336 5 Zellzahl Zellzahl NNP cord-006856-b1w25ob5 1336 6 von von NNP cord-006856-b1w25ob5 1336 7 durchschnittlich durchschnittlich NNP cord-006856-b1w25ob5 1337 1 2 2 CD cord-006856-b1w25ob5 1337 2 × × CD cord-006856-b1w25ob5 1337 3 10 10 CD cord-006856-b1w25ob5 1337 4 5 5 CD cord-006856-b1w25ob5 1337 5 Zellen Zellen NNP cord-006856-b1w25ob5 1337 6 isoliert isoliert NN cord-006856-b1w25ob5 1337 7 . . . cord-006856-b1w25ob5 1338 1 Beste Beste NNP cord-006856-b1w25ob5 1338 2 Resultate Resultate NNP cord-006856-b1w25ob5 1338 3 wurden wurden VBD cord-006856-b1w25ob5 1338 4 mit mit NNP cord-006856-b1w25ob5 1338 5 dem dem NNP cord-006856-b1w25ob5 1338 6 Lymphoprep Lymphoprep NNP cord-006856-b1w25ob5 1338 7 TM TM NNP cord-006856-b1w25ob5 1338 8 -Dichtegradienten -dichtegradienten WDT cord-006856-b1w25ob5 1338 9 erzielt erzielt NNS cord-006856-b1w25ob5 1338 10 . . . cord-006856-b1w25ob5 1339 1 Isolierte Isolierte NNP cord-006856-b1w25ob5 1339 2 porcine porcine JJ cord-006856-b1w25ob5 1339 3 Inselzellen Inselzellen NNP cord-006856-b1w25ob5 1339 4 überleben überleben NN cord-006856-b1w25ob5 1339 5 bei bei NNP cord-006856-b1w25ob5 1339 6 37 37 CD cord-006856-b1w25ob5 1339 7 ° ° NNS cord-006856-b1w25ob5 1340 1 C C NNP cord-006856-b1w25ob5 1340 2 i -PRON- PRP cord-006856-b1w25ob5 1340 3 m be VBP cord-006856-b1w25ob5 1340 4 Durchschnitt Durchschnitt NNP cord-006856-b1w25ob5 1340 5 12 12 CD cord-006856-b1w25ob5 1340 6 Tage Tage NNP cord-006856-b1w25ob5 1340 7 in in IN cord-006856-b1w25ob5 1340 8 vivo vivo NN cord-006856-b1w25ob5 1341 1 und und IN cord-006856-b1w25ob5 1341 2 produzieren produzieren NNP cord-006856-b1w25ob5 1341 3 Glucose Glucose NNP cord-006856-b1w25ob5 1341 4 - - HYPH cord-006856-b1w25ob5 1341 5 abhängig abhängig NNS cord-006856-b1w25ob5 1341 6 Insulin Insulin NNP cord-006856-b1w25ob5 1341 7 . . . cord-006856-b1w25ob5 1342 1 Die die VB cord-006856-b1w25ob5 1342 2 Funktionalität Funktionalität NNP cord-006856-b1w25ob5 1342 3 der der NN cord-006856-b1w25ob5 1342 4 Zellen Zellen NNP cord-006856-b1w25ob5 1342 5 bleibt bleibt NNP cord-006856-b1w25ob5 1342 6 über über NNP cord-006856-b1w25ob5 1342 7 den den NNP cord-006856-b1w25ob5 1342 8 gesamten gesamten NNP cord-006856-b1w25ob5 1342 9 Zeitraum Zeitraum NNP cord-006856-b1w25ob5 1342 10 erhalten erhalten NNP cord-006856-b1w25ob5 1342 11 . . . cord-006856-b1w25ob5 1343 1 Mikroverkapselung Mikroverkapselung NNP cord-006856-b1w25ob5 1344 1 mit mit NNP cord-006856-b1w25ob5 1344 2 NaCS NaCS NNP cord-006856-b1w25ob5 1344 3 ist ist NNP cord-006856-b1w25ob5 1344 4 machbar machbar NN cord-006856-b1w25ob5 1344 5 . . . cord-006856-b1w25ob5 1345 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 1345 2 . . . cord-006856-b1w25ob5 1346 1 Die die VB cord-006856-b1w25ob5 1346 2 Isolation isolation NN cord-006856-b1w25ob5 1346 3 porciner porciner NN cord-006856-b1w25ob5 1346 4 Inselzellen inselzellen NN cord-006856-b1w25ob5 1346 5 ist ist NN cord-006856-b1w25ob5 1347 1 eine eine NNP cord-006856-b1w25ob5 1347 2 viel viel FW cord-006856-b1w25ob5 1347 3 versprechende versprechende NNP cord-006856-b1w25ob5 1347 4 Methode Methode NNP cord-006856-b1w25ob5 1347 5 den den NNP cord-006856-b1w25ob5 1347 6 Mangel Mangel NNP cord-006856-b1w25ob5 1347 7 an an DT cord-006856-b1w25ob5 1347 8 humanen humanen NNP cord-006856-b1w25ob5 1347 9 Spenderorganen Spenderorganen NNP cord-006856-b1w25ob5 1347 10 in in IN cord-006856-b1w25ob5 1347 11 der der NNP cord-006856-b1w25ob5 1347 12 Pankreastransplantation Pankreastransplantation NNP cord-006856-b1w25ob5 1348 1 und und IN cord-006856-b1w25ob5 1348 2 humanen humanen NNP cord-006856-b1w25ob5 1348 3 Inselzelltransplantation Inselzelltransplantation NNP cord-006856-b1w25ob5 1348 4 zu zu NNP cord-006856-b1w25ob5 1348 5 umgehen umgehen NNP cord-006856-b1w25ob5 1348 6 . . . cord-006856-b1w25ob5 1349 1 NaCS NaCS NNP cord-006856-b1w25ob5 1349 2 als als NNP cord-006856-b1w25ob5 1349 3 Verkapselungsmaterial Verkapselungsmaterial NNP cord-006856-b1w25ob5 1349 4 ist ist NN cord-006856-b1w25ob5 1349 5 weniger weniger NN cord-006856-b1w25ob5 1349 6 immunogen immunogen NN cord-006856-b1w25ob5 1349 7 und und IN cord-006856-b1w25ob5 1349 8 weitaus weitaus NNP cord-006856-b1w25ob5 1349 9 biokompatibler biokompatibler NNP cord-006856-b1w25ob5 1349 10 als als NNP cord-006856-b1w25ob5 1349 11 alle alle NNP cord-006856-b1w25ob5 1349 12 bisher bisher CD cord-006856-b1w25ob5 1349 13 verwendeten verwendeten NNP cord-006856-b1w25ob5 1350 1 Materialien Materialien NNP cord-006856-b1w25ob5 1350 2 und und RB cord-006856-b1w25ob5 1350 3 die die VBP cord-006856-b1w25ob5 1350 4 Mikroverkapselung Mikroverkapselung NNP cord-006856-b1w25ob5 1350 5 xenogener xenogener NNP cord-006856-b1w25ob5 1350 6 Inselzellen Inselzellen NNP cord-006856-b1w25ob5 1350 7 mit mit NNP cord-006856-b1w25ob5 1350 8 NaCS NaCS NNP cord-006856-b1w25ob5 1350 9 scheint scheint NNP cord-006856-b1w25ob5 1351 1 eine eine JJ cord-006856-b1w25ob5 1351 2 innovative innovative JJ cord-006856-b1w25ob5 1351 3 Methode Methode NNP cord-006856-b1w25ob5 1351 4 zur zur NNP cord-006856-b1w25ob5 1351 5 Therapie Therapie NNP cord-006856-b1w25ob5 1351 6 des des FW cord-006856-b1w25ob5 1351 7 Diabetes diabetes NN cord-006856-b1w25ob5 1351 8 mellitus mellitus NN cord-006856-b1w25ob5 1351 9 zu zu NNP cord-006856-b1w25ob5 1351 10 sein sein NNP cord-006856-b1w25ob5 1351 11 . . . cord-006856-b1w25ob5 1352 1 Background background NN cord-006856-b1w25ob5 1352 2 . . . cord-006856-b1w25ob5 1353 1 To to TO cord-006856-b1w25ob5 1353 2 achieve achieve VB cord-006856-b1w25ob5 1353 3 its -PRON- PRP$ cord-006856-b1w25ob5 1353 4 full full JJ cord-006856-b1w25ob5 1353 5 potential potential NN cord-006856-b1w25ob5 1353 6 , , , cord-006856-b1w25ob5 1353 7 transplantation transplantation NN cord-006856-b1w25ob5 1353 8 of of IN cord-006856-b1w25ob5 1353 9 pancreatic pancreatic JJ cord-006856-b1w25ob5 1353 10 islets islet NNS cord-006856-b1w25ob5 1353 11 has have VBZ cord-006856-b1w25ob5 1353 12 to to TO cord-006856-b1w25ob5 1353 13 overcome overcome VB cord-006856-b1w25ob5 1353 14 a a DT cord-006856-b1w25ob5 1353 15 number number NN cord-006856-b1w25ob5 1353 16 of of IN cord-006856-b1w25ob5 1353 17 obstacles obstacle NNS cord-006856-b1w25ob5 1353 18 . . . cord-006856-b1w25ob5 1354 1 One one CD cord-006856-b1w25ob5 1354 2 of of IN cord-006856-b1w25ob5 1354 3 the the DT cord-006856-b1w25ob5 1354 4 obstacles obstacle NNS cord-006856-b1w25ob5 1354 5 are be VBP cord-006856-b1w25ob5 1354 6 the the DT cord-006856-b1w25ob5 1354 7 still still RB cord-006856-b1w25ob5 1354 8 lacking lack VBG cord-006856-b1w25ob5 1354 9 read read VB cord-006856-b1w25ob5 1354 10 - - HYPH cord-006856-b1w25ob5 1354 11 out out RP cord-006856-b1w25ob5 1354 12 parameters parameter NNS cord-006856-b1w25ob5 1354 13 to to TO cord-006856-b1w25ob5 1354 14 assess assess VB cord-006856-b1w25ob5 1354 15 the the DT cord-006856-b1w25ob5 1354 16 quality quality NN cord-006856-b1w25ob5 1354 17 of of IN cord-006856-b1w25ob5 1354 18 human human JJ cord-006856-b1w25ob5 1354 19 islets islet NNS cord-006856-b1w25ob5 1354 20 after after IN cord-006856-b1w25ob5 1354 21 the the DT cord-006856-b1w25ob5 1354 22 isolation isolation NN cord-006856-b1w25ob5 1354 23 procedure procedure NN cord-006856-b1w25ob5 1354 24 and and CC cord-006856-b1w25ob5 1354 25 prior prior RB cord-006856-b1w25ob5 1354 26 to to IN cord-006856-b1w25ob5 1354 27 transplantation transplantation NN cord-006856-b1w25ob5 1354 28 . . . cord-006856-b1w25ob5 1355 1 Being be VBG cord-006856-b1w25ob5 1355 2 able able JJ cord-006856-b1w25ob5 1355 3 to to TO cord-006856-b1w25ob5 1355 4 predict predict VB cord-006856-b1w25ob5 1355 5 the the DT cord-006856-b1w25ob5 1355 6 functional functional JJ cord-006856-b1w25ob5 1355 7 potential potential NN cord-006856-b1w25ob5 1355 8 of of IN cord-006856-b1w25ob5 1355 9 the the DT cord-006856-b1w25ob5 1355 10 pancreatic pancreatic JJ cord-006856-b1w25ob5 1355 11 islets islet NNS cord-006856-b1w25ob5 1355 12 after after IN cord-006856-b1w25ob5 1355 13 isolation isolation NN cord-006856-b1w25ob5 1355 14 or or CC cord-006856-b1w25ob5 1355 15 even even RB cord-006856-b1w25ob5 1355 16 short short JJ cord-006856-b1w25ob5 1355 17 - - HYPH cord-006856-b1w25ob5 1355 18 term term NN cord-006856-b1w25ob5 1355 19 culture culture NN cord-006856-b1w25ob5 1355 20 would would MD cord-006856-b1w25ob5 1355 21 greatly greatly RB cord-006856-b1w25ob5 1355 22 enhance enhance VB cord-006856-b1w25ob5 1355 23 the the DT cord-006856-b1w25ob5 1355 24 success success NN cord-006856-b1w25ob5 1355 25 of of IN cord-006856-b1w25ob5 1355 26 islet islet NN cord-006856-b1w25ob5 1355 27 transplantation transplantation NN cord-006856-b1w25ob5 1355 28 . . . cord-006856-b1w25ob5 1356 1 Therefore therefore RB cord-006856-b1w25ob5 1356 2 one one CD cord-006856-b1w25ob5 1356 3 of of IN cord-006856-b1w25ob5 1356 4 the the DT cord-006856-b1w25ob5 1356 5 primary primary JJ cord-006856-b1w25ob5 1356 6 challenges challenge NNS cord-006856-b1w25ob5 1356 7 in in IN cord-006856-b1w25ob5 1356 8 islet islet NN cord-006856-b1w25ob5 1356 9 transplantation transplantation NN cord-006856-b1w25ob5 1356 10 is be VBZ cord-006856-b1w25ob5 1356 11 to to TO cord-006856-b1w25ob5 1356 12 identify identify VB cord-006856-b1w25ob5 1356 13 and and CC cord-006856-b1w25ob5 1356 14 understand understand VB cord-006856-b1w25ob5 1356 15 the the DT cord-006856-b1w25ob5 1356 16 changes change NNS cord-006856-b1w25ob5 1356 17 taking take VBG cord-006856-b1w25ob5 1356 18 place place NN cord-006856-b1w25ob5 1356 19 in in IN cord-006856-b1w25ob5 1356 20 islets islet NNS cord-006856-b1w25ob5 1356 21 after after IN cord-006856-b1w25ob5 1356 22 isolation isolation NN cord-006856-b1w25ob5 1356 23 or or CC cord-006856-b1w25ob5 1356 24 culture culture NN cord-006856-b1w25ob5 1356 25 . . . cord-006856-b1w25ob5 1357 1 Life life NN cord-006856-b1w25ob5 1357 2 confocal confocal JJ cord-006856-b1w25ob5 1357 3 microscopy microscopy NN cord-006856-b1w25ob5 1357 4 is be VBZ cord-006856-b1w25ob5 1357 5 a a DT cord-006856-b1w25ob5 1357 6 powerful powerful JJ cord-006856-b1w25ob5 1357 7 tool tool NN cord-006856-b1w25ob5 1357 8 to to TO cord-006856-b1w25ob5 1357 9 identify identify VB cord-006856-b1w25ob5 1357 10 such such JJ cord-006856-b1w25ob5 1357 11 changes change NNS cord-006856-b1w25ob5 1357 12 in in IN cord-006856-b1w25ob5 1357 13 living live VBG cord-006856-b1w25ob5 1357 14 islets islet NNS cord-006856-b1w25ob5 1357 15 not not RB cord-006856-b1w25ob5 1357 16 achievable achievable JJ cord-006856-b1w25ob5 1357 17 by by IN cord-006856-b1w25ob5 1357 18 use use NN cord-006856-b1w25ob5 1357 19 of of IN cord-006856-b1w25ob5 1357 20 fixed fix VBN cord-006856-b1w25ob5 1357 21 - - HYPH cord-006856-b1w25ob5 1357 22 cell cell NN cord-006856-b1w25ob5 1357 23 techniques technique NNS cord-006856-b1w25ob5 1357 24 . . . cord-006856-b1w25ob5 1358 1 Methods method NNS cord-006856-b1w25ob5 1358 2 . . . cord-006856-b1w25ob5 1359 1 Islets islet NNS cord-006856-b1w25ob5 1359 2 were be VBD cord-006856-b1w25ob5 1359 3 isolated isolate VBN cord-006856-b1w25ob5 1359 4 according accord VBG cord-006856-b1w25ob5 1359 5 to to IN cord-006856-b1w25ob5 1359 6 the the DT cord-006856-b1w25ob5 1359 7 method method NN cord-006856-b1w25ob5 1359 8 of of IN cord-006856-b1w25ob5 1359 9 Ricordi Ricordi NNP cord-006856-b1w25ob5 1359 10 et et NNP cord-006856-b1w25ob5 1359 11 al al NNP cord-006856-b1w25ob5 1359 12 . . . cord-006856-b1w25ob5 1360 1 , , , cord-006856-b1w25ob5 1360 2 using use VBG cord-006856-b1w25ob5 1360 3 a a DT cord-006856-b1w25ob5 1360 4 continuous continuous JJ cord-006856-b1w25ob5 1360 5 Ficoll Ficoll NNP cord-006856-b1w25ob5 1360 6 gradient gradient NN cord-006856-b1w25ob5 1360 7 . . . cord-006856-b1w25ob5 1361 1 3 3 CD cord-006856-b1w25ob5 1361 2 fluorescent fluorescent NN cord-006856-b1w25ob5 1361 3 dyes dye NNS cord-006856-b1w25ob5 1361 4 , , , cord-006856-b1w25ob5 1361 5 dichlorodihydrofluorescein dichlorodihydrofluorescein NNP cord-006856-b1w25ob5 1361 6 diacetate diacetate NN cord-006856-b1w25ob5 1361 7 ( ( -LRB- cord-006856-b1w25ob5 1361 8 DCF DCF NNP cord-006856-b1w25ob5 1361 9 ) ) -RRB- cord-006856-b1w25ob5 1361 10 , , , cord-006856-b1w25ob5 1361 11 tetramethylrhodamine tetramethylrhodamine NN cord-006856-b1w25ob5 1361 12 methyl methyl NN cord-006856-b1w25ob5 1361 13 ester ester NN cord-006856-b1w25ob5 1361 14 ( ( -LRB- cord-006856-b1w25ob5 1361 15 TMRM TMRM NNP cord-006856-b1w25ob5 1361 16 ) ) -RRB- cord-006856-b1w25ob5 1361 17 , , , cord-006856-b1w25ob5 1361 18 and and CC cord-006856-b1w25ob5 1361 19 fluorescent fluorescent JJ cord-006856-b1w25ob5 1361 20 wheat wheat NN cord-006856-b1w25ob5 1361 21 germ germ NN cord-006856-b1w25ob5 1361 22 agglutinin agglutinin NNS cord-006856-b1w25ob5 1361 23 were be VBD cord-006856-b1w25ob5 1361 24 used use VBN cord-006856-b1w25ob5 1361 25 to to TO cord-006856-b1w25ob5 1361 26 assess assess VB cord-006856-b1w25ob5 1361 27 either either CC cord-006856-b1w25ob5 1361 28 overall overall JJ cord-006856-b1w25ob5 1361 29 oxidative oxidative JJ cord-006856-b1w25ob5 1361 30 stress stress NN cord-006856-b1w25ob5 1361 31 , , , cord-006856-b1w25ob5 1361 32 time time NN cord-006856-b1w25ob5 1361 33 - - HYPH cord-006856-b1w25ob5 1361 34 dependent dependent JJ cord-006856-b1w25ob5 1361 35 mitochondrial mitochondrial JJ cord-006856-b1w25ob5 1361 36 membrane membrane NN cord-006856-b1w25ob5 1361 37 potentials potential NNS cord-006856-b1w25ob5 1361 38 , , , cord-006856-b1w25ob5 1361 39 or or CC cord-006856-b1w25ob5 1361 40 localisation localisation NN cord-006856-b1w25ob5 1361 41 of of IN cord-006856-b1w25ob5 1361 42 oligosaccharides oligosaccharide NNS cord-006856-b1w25ob5 1361 43 . . . cord-006856-b1w25ob5 1362 1 Confocal Confocal NNP cord-006856-b1w25ob5 1362 2 microscopy microscopy NNS cord-006856-b1w25ob5 1362 3 was be VBD cord-006856-b1w25ob5 1362 4 performed perform VBN cord-006856-b1w25ob5 1362 5 with with IN cord-006856-b1w25ob5 1362 6 an an DT cord-006856-b1w25ob5 1362 7 microlens microlens NN cord-006856-b1w25ob5 1362 8 - - HYPH cord-006856-b1w25ob5 1362 9 enhanced enhance VBN cord-006856-b1w25ob5 1362 10 Nipkow Nipkow NNP cord-006856-b1w25ob5 1362 11 disk disk NN cord-006856-b1w25ob5 1362 12 - - HYPH cord-006856-b1w25ob5 1362 13 based base VBN cord-006856-b1w25ob5 1362 14 confocal confocal JJ cord-006856-b1w25ob5 1362 15 system system NN cord-006856-b1w25ob5 1362 16 UltraVIEW UltraVIEW NNP cord-006856-b1w25ob5 1362 17 RS rs NN cord-006856-b1w25ob5 1363 1 ( ( -LRB- cord-006856-b1w25ob5 1363 2 Perkin Perkin NNP cord-006856-b1w25ob5 1363 3 Elmer Elmer NNP cord-006856-b1w25ob5 1363 4 , , , cord-006856-b1w25ob5 1363 5 Wellesey Wellesey NNP cord-006856-b1w25ob5 1363 6 , , , cord-006856-b1w25ob5 1363 7 MA MA NNP cord-006856-b1w25ob5 1363 8 , , , cord-006856-b1w25ob5 1363 9 USA USA NNP cord-006856-b1w25ob5 1363 10 ) ) -RRB- cord-006856-b1w25ob5 1363 11 mounted mount VBD cord-006856-b1w25ob5 1363 12 on on IN cord-006856-b1w25ob5 1363 13 an an DT cord-006856-b1w25ob5 1363 14 Olympus Olympus NNP cord-006856-b1w25ob5 1363 15 IX-70 IX-70 NNP cord-006856-b1w25ob5 1363 16 inverse inverse JJ cord-006856-b1w25ob5 1363 17 microscope microscope NN cord-006856-b1w25ob5 1363 18 ( ( -LRB- cord-006856-b1w25ob5 1363 19 Olympus Olympus NNP cord-006856-b1w25ob5 1363 20 , , , cord-006856-b1w25ob5 1363 21 Nagano Nagano NNP cord-006856-b1w25ob5 1363 22 , , , cord-006856-b1w25ob5 1363 23 Japan Japan NNP cord-006856-b1w25ob5 1363 24 ) ) -RRB- cord-006856-b1w25ob5 1363 25 . . . cord-006856-b1w25ob5 1364 1 Results result NNS cord-006856-b1w25ob5 1364 2 . . . cord-006856-b1w25ob5 1365 1 With with IN cord-006856-b1w25ob5 1365 2 the the DT cord-006856-b1w25ob5 1365 3 above above RB cord-006856-b1w25ob5 1365 4 described describe VBN cord-006856-b1w25ob5 1365 5 confocal confocal JJ cord-006856-b1w25ob5 1365 6 system system NN cord-006856-b1w25ob5 1365 7 we -PRON- PRP cord-006856-b1w25ob5 1365 8 were be VBD cord-006856-b1w25ob5 1365 9 able able JJ cord-006856-b1w25ob5 1365 10 to to TO cord-006856-b1w25ob5 1365 11 identify identify VB cord-006856-b1w25ob5 1365 12 differences difference NNS cord-006856-b1w25ob5 1365 13 in in IN cord-006856-b1w25ob5 1365 14 the the DT cord-006856-b1w25ob5 1365 15 localisation localisation NN cord-006856-b1w25ob5 1365 16 and and CC cord-006856-b1w25ob5 1365 17 amount amount NN cord-006856-b1w25ob5 1365 18 of of IN cord-006856-b1w25ob5 1365 19 oligosaccharides oligosaccharide NNS cord-006856-b1w25ob5 1365 20 in in IN cord-006856-b1w25ob5 1365 21 endocrine endocrine NN cord-006856-b1w25ob5 1365 22 vs. vs. IN cord-006856-b1w25ob5 1365 23 exocrine exocrine JJ cord-006856-b1w25ob5 1365 24 cells cell NNS cord-006856-b1w25ob5 1365 25 of of IN cord-006856-b1w25ob5 1365 26 freshly freshly RB cord-006856-b1w25ob5 1365 27 isolated isolate VBN cord-006856-b1w25ob5 1365 28 pancreatic pancreatic JJ cord-006856-b1w25ob5 1365 29 islets islet NNS cord-006856-b1w25ob5 1365 30 . . . cord-006856-b1w25ob5 1366 1 The the DT cord-006856-b1w25ob5 1366 2 staining staining NN cord-006856-b1w25ob5 1366 3 pattern pattern NN cord-006856-b1w25ob5 1366 4 changed change VBN cord-006856-b1w25ob5 1366 5 during during IN cord-006856-b1w25ob5 1366 6 the the DT cord-006856-b1w25ob5 1366 7 course course NN cord-006856-b1w25ob5 1366 8 of of IN cord-006856-b1w25ob5 1366 9 culture culture NN cord-006856-b1w25ob5 1366 10 , , , cord-006856-b1w25ob5 1366 11 suggesting suggest VBG cord-006856-b1w25ob5 1366 12 a a DT cord-006856-b1w25ob5 1366 13 remodeling remodeling NN cord-006856-b1w25ob5 1366 14 of of IN cord-006856-b1w25ob5 1366 15 cell cell NN cord-006856-b1w25ob5 1366 16 surface surface NN cord-006856-b1w25ob5 1366 17 oligosaccharides oligosaccharide NNS cord-006856-b1w25ob5 1366 18 . . . cord-006856-b1w25ob5 1367 1 The the DT cord-006856-b1w25ob5 1367 2 study study NN cord-006856-b1w25ob5 1367 3 of of IN cord-006856-b1w25ob5 1367 4 the the DT cord-006856-b1w25ob5 1367 5 mitochondrial mitochondrial JJ cord-006856-b1w25ob5 1367 6 membrane membrane NN cord-006856-b1w25ob5 1367 7 potential potential NN cord-006856-b1w25ob5 1367 8 proved prove VBD cord-006856-b1w25ob5 1367 9 to to TO cord-006856-b1w25ob5 1367 10 be be VB cord-006856-b1w25ob5 1367 11 very very RB cord-006856-b1w25ob5 1367 12 useful useful JJ cord-006856-b1w25ob5 1367 13 in in IN cord-006856-b1w25ob5 1367 14 order order NN cord-006856-b1w25ob5 1367 15 to to TO cord-006856-b1w25ob5 1367 16 early early RB cord-006856-b1w25ob5 1367 17 identify identify VB cord-006856-b1w25ob5 1367 18 damaged damage VBN cord-006856-b1w25ob5 1367 19 or or CC cord-006856-b1w25ob5 1367 20 stressed stress VBN cord-006856-b1w25ob5 1367 21 cells cell NNS cord-006856-b1w25ob5 1367 22 and and CC cord-006856-b1w25ob5 1367 23 thereby thereby RB cord-006856-b1w25ob5 1367 24 gain gain VB cord-006856-b1w25ob5 1367 25 insights insight NNS cord-006856-b1w25ob5 1367 26 into into IN cord-006856-b1w25ob5 1367 27 the the DT cord-006856-b1w25ob5 1367 28 vitality vitality NN cord-006856-b1w25ob5 1367 29 of of IN cord-006856-b1w25ob5 1367 30 the the DT cord-006856-b1w25ob5 1367 31 isolated isolate VBN cord-006856-b1w25ob5 1367 32 islets islet NNS cord-006856-b1w25ob5 1367 33 . . . cord-006856-b1w25ob5 1368 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1368 2 . . . cord-006856-b1w25ob5 1369 1 This this DT cord-006856-b1w25ob5 1369 2 makes make VBZ cord-006856-b1w25ob5 1369 3 us -PRON- PRP cord-006856-b1w25ob5 1369 4 believe believe VB cord-006856-b1w25ob5 1369 5 that that IN cord-006856-b1w25ob5 1369 6 , , , cord-006856-b1w25ob5 1369 7 especially especially RB cord-006856-b1w25ob5 1369 8 in in IN cord-006856-b1w25ob5 1369 9 the the DT cord-006856-b1w25ob5 1369 10 light light NN cord-006856-b1w25ob5 1369 11 of of IN cord-006856-b1w25ob5 1369 12 the the DT cord-006856-b1w25ob5 1369 13 many many JJ cord-006856-b1w25ob5 1369 14 other other JJ cord-006856-b1w25ob5 1369 15 fluorescent fluorescent JJ cord-006856-b1w25ob5 1369 16 dyes dye NNS cord-006856-b1w25ob5 1369 17 which which WDT cord-006856-b1w25ob5 1369 18 can can MD cord-006856-b1w25ob5 1369 19 be be VB cord-006856-b1w25ob5 1369 20 used use VBN cord-006856-b1w25ob5 1369 21 as as IN cord-006856-b1w25ob5 1369 22 subcellular subcellular JJ cord-006856-b1w25ob5 1369 23 markers marker NNS cord-006856-b1w25ob5 1369 24 , , , cord-006856-b1w25ob5 1369 25 a a DT cord-006856-b1w25ob5 1369 26 combination combination NN cord-006856-b1w25ob5 1369 27 of of IN cord-006856-b1w25ob5 1369 28 these these DT cord-006856-b1w25ob5 1369 29 with with IN cord-006856-b1w25ob5 1369 30 a a DT cord-006856-b1w25ob5 1369 31 powerful powerful JJ cord-006856-b1w25ob5 1369 32 live live JJ cord-006856-b1w25ob5 1369 33 confocal confocal JJ cord-006856-b1w25ob5 1369 34 imaging imaging NN cord-006856-b1w25ob5 1369 35 system system NN cord-006856-b1w25ob5 1369 36 will will MD cord-006856-b1w25ob5 1369 37 be be VB cord-006856-b1w25ob5 1369 38 of of IN cord-006856-b1w25ob5 1369 39 great great JJ cord-006856-b1w25ob5 1369 40 value value NN cord-006856-b1w25ob5 1369 41 for for IN cord-006856-b1w25ob5 1369 42 a a DT cord-006856-b1w25ob5 1369 43 better well JJR cord-006856-b1w25ob5 1369 44 islet islet NN cord-006856-b1w25ob5 1369 45 assessment assessment NN cord-006856-b1w25ob5 1369 46 after after IN cord-006856-b1w25ob5 1369 47 isolation isolation NN cord-006856-b1w25ob5 1369 48 and and CC cord-006856-b1w25ob5 1369 49 culture culture NN cord-006856-b1w25ob5 1369 50 . . . cord-006856-b1w25ob5 1370 1 Background background NN cord-006856-b1w25ob5 1370 2 . . . cord-006856-b1w25ob5 1371 1 Therapeutic therapeutic JJ cord-006856-b1w25ob5 1371 2 drug drug NN cord-006856-b1w25ob5 1371 3 monitoring monitoring NN cord-006856-b1w25ob5 1371 4 ( ( -LRB- cord-006856-b1w25ob5 1371 5 TDM TDM NNP cord-006856-b1w25ob5 1371 6 ) ) -RRB- cord-006856-b1w25ob5 1371 7 of of IN cord-006856-b1w25ob5 1371 8 immunosuppressants immunosuppressant NNS cord-006856-b1w25ob5 1371 9 is be VBZ cord-006856-b1w25ob5 1371 10 a a DT cord-006856-b1w25ob5 1371 11 well well RB cord-006856-b1w25ob5 1371 12 established establish VBN cord-006856-b1w25ob5 1371 13 concept concept NN cord-006856-b1w25ob5 1371 14 supporting support VBG cord-006856-b1w25ob5 1371 15 the the DT cord-006856-b1w25ob5 1371 16 work work NN cord-006856-b1w25ob5 1371 17 of of IN cord-006856-b1w25ob5 1371 18 clinicians clinician NNS cord-006856-b1w25ob5 1371 19 from from IN cord-006856-b1w25ob5 1371 20 the the DT cord-006856-b1w25ob5 1371 21 historical historical JJ cord-006856-b1w25ob5 1371 22 onset onset NN cord-006856-b1w25ob5 1371 23 of of IN cord-006856-b1w25ob5 1371 24 the the DT cord-006856-b1w25ob5 1371 25 use use NN cord-006856-b1w25ob5 1371 26 of of IN cord-006856-b1w25ob5 1371 27 these these DT cord-006856-b1w25ob5 1371 28 drugs drug NNS cord-006856-b1w25ob5 1371 29 . . . cord-006856-b1w25ob5 1372 1 Within within IN cord-006856-b1w25ob5 1372 2 the the DT cord-006856-b1w25ob5 1372 3 last last JJ cord-006856-b1w25ob5 1372 4 years year NNS cord-006856-b1w25ob5 1372 5 the the DT cord-006856-b1w25ob5 1372 6 combination combination NN cord-006856-b1w25ob5 1372 7 of of IN cord-006856-b1w25ob5 1372 8 HPLC HPLC NNP cord-006856-b1w25ob5 1372 9 ( ( -LRB- cord-006856-b1w25ob5 1372 10 highperformance highperformance JJ cord-006856-b1w25ob5 1372 11 liquid liquid NN cord-006856-b1w25ob5 1372 12 chromatography chromatography NN cord-006856-b1w25ob5 1372 13 ) ) -RRB- cord-006856-b1w25ob5 1372 14 with with IN cord-006856-b1w25ob5 1372 15 tandem tandem JJ cord-006856-b1w25ob5 1372 16 mass mass NN cord-006856-b1w25ob5 1372 17 spectrometry spectrometry NN cord-006856-b1w25ob5 1372 18 ( ( -LRB- cord-006856-b1w25ob5 1372 19 MS MS NNP cord-006856-b1w25ob5 1372 20 / / SYM cord-006856-b1w25ob5 1372 21 MS MS NNP cord-006856-b1w25ob5 1372 22 ) ) -RRB- cord-006856-b1w25ob5 1372 23 provides provide VBZ cord-006856-b1w25ob5 1372 24 an an DT cord-006856-b1w25ob5 1372 25 alternative alternative NN cord-006856-b1w25ob5 1372 26 to to IN cord-006856-b1w25ob5 1372 27 antibody antibody NN cord-006856-b1w25ob5 1372 28 - - HYPH cord-006856-b1w25ob5 1372 29 based base VBN cord-006856-b1w25ob5 1372 30 immunoassays immunoassay NNS cord-006856-b1w25ob5 1372 31 . . . cord-006856-b1w25ob5 1373 1 This this DT cord-006856-b1w25ob5 1373 2 new new JJ cord-006856-b1w25ob5 1373 3 analytical analytical JJ cord-006856-b1w25ob5 1373 4 method method NN cord-006856-b1w25ob5 1373 5 to to TO cord-006856-b1w25ob5 1373 6 quantify quantify VB cord-006856-b1w25ob5 1373 7 immunosuppressants immunosuppressant NNS cord-006856-b1w25ob5 1373 8 affords afford VBZ cord-006856-b1w25ob5 1373 9 a a DT cord-006856-b1w25ob5 1373 10 robust robust JJ cord-006856-b1w25ob5 1373 11 and and CC cord-006856-b1w25ob5 1373 12 rapid rapid JJ cord-006856-b1w25ob5 1373 13 separation separation NN cord-006856-b1w25ob5 1373 14 technique technique NN cord-006856-b1w25ob5 1373 15 with with IN cord-006856-b1w25ob5 1373 16 high high JJ cord-006856-b1w25ob5 1373 17 selectivity selectivity NN cord-006856-b1w25ob5 1373 18 . . . cord-006856-b1w25ob5 1374 1 Up up IN cord-006856-b1w25ob5 1374 2 to to IN cord-006856-b1w25ob5 1374 3 now now RB cord-006856-b1w25ob5 1374 4 , , , cord-006856-b1w25ob5 1374 5 the the DT cord-006856-b1w25ob5 1374 6 quantification quantification NN cord-006856-b1w25ob5 1374 7 of of IN cord-006856-b1w25ob5 1374 8 wholeblood wholeblood NN cord-006856-b1w25ob5 1374 9 levels level NNS cord-006856-b1w25ob5 1374 10 of of IN cord-006856-b1w25ob5 1374 11 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 1374 12 A A NNP cord-006856-b1w25ob5 1374 13 , , , cord-006856-b1w25ob5 1374 14 FK FK NNP cord-006856-b1w25ob5 1374 15 506 506 CD cord-006856-b1w25ob5 1374 16 ( ( -LRB- cord-006856-b1w25ob5 1374 17 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1374 18 ) ) -RRB- cord-006856-b1w25ob5 1374 19 , , , cord-006856-b1w25ob5 1374 20 and and CC cord-006856-b1w25ob5 1374 21 42-O-(2-hydroxyethyl)-Rapamycin 42-o-(2-hydroxyethyl)-rapamycin CD cord-006856-b1w25ob5 1374 22 ( ( -LRB- cord-006856-b1w25ob5 1374 23 Everolimus Everolimus NNP cord-006856-b1w25ob5 1374 24 ) ) -RRB- cord-006856-b1w25ob5 1374 25 at at IN cord-006856-b1w25ob5 1374 26 our -PRON- PRP$ cord-006856-b1w25ob5 1374 27 institute institute NN cord-006856-b1w25ob5 1374 28 have have VBP cord-006856-b1w25ob5 1374 29 relied rely VBN cord-006856-b1w25ob5 1374 30 upon upon IN cord-006856-b1w25ob5 1374 31 three three CD cord-006856-b1w25ob5 1374 32 different different JJ cord-006856-b1w25ob5 1374 33 , , , cord-006856-b1w25ob5 1374 34 indirect indirect JJ cord-006856-b1w25ob5 1374 35 assays assay NNS cord-006856-b1w25ob5 1374 36 from from IN cord-006856-b1w25ob5 1374 37 different different JJ cord-006856-b1w25ob5 1374 38 companies company NNS cord-006856-b1w25ob5 1374 39 . . . cord-006856-b1w25ob5 1375 1 However however RB cord-006856-b1w25ob5 1375 2 , , , cord-006856-b1w25ob5 1375 3 these these DT cord-006856-b1w25ob5 1375 4 systems system NNS cord-006856-b1w25ob5 1375 5 have have VBP cord-006856-b1w25ob5 1375 6 drawbacks drawback NNS cord-006856-b1w25ob5 1375 7 caused cause VBN cord-006856-b1w25ob5 1375 8 by by IN cord-006856-b1w25ob5 1375 9 cross cross NN cord-006856-b1w25ob5 1375 10 reactions reaction NNS cord-006856-b1w25ob5 1375 11 with with IN cord-006856-b1w25ob5 1375 12 active active JJ cord-006856-b1w25ob5 1375 13 and and CC cord-006856-b1w25ob5 1375 14 inactive inactive JJ cord-006856-b1w25ob5 1375 15 drug drug NN cord-006856-b1w25ob5 1375 16 metabolites metabolite NNS cord-006856-b1w25ob5 1375 17 , , , cord-006856-b1w25ob5 1375 18 fluctuations fluctuation NNS cord-006856-b1w25ob5 1375 19 in in IN cord-006856-b1w25ob5 1375 20 assay assay NN cord-006856-b1w25ob5 1375 21 performance performance NN cord-006856-b1w25ob5 1375 22 , , , cord-006856-b1w25ob5 1375 23 and and CC cord-006856-b1w25ob5 1375 24 comparatively comparatively RB cord-006856-b1w25ob5 1375 25 high high JJ cord-006856-b1w25ob5 1375 26 prices price NNS cord-006856-b1w25ob5 1375 27 . . . cord-006856-b1w25ob5 1376 1 In in IN cord-006856-b1w25ob5 1376 2 contrast contrast NN cord-006856-b1w25ob5 1376 3 , , , cord-006856-b1w25ob5 1376 4 HPLC HPLC NNP cord-006856-b1w25ob5 1376 5 - - HYPH cord-006856-b1w25ob5 1376 6 MS MS NNP cord-006856-b1w25ob5 1376 7 / / SYM cord-006856-b1w25ob5 1376 8 MS MS NNP cord-006856-b1w25ob5 1376 9 platforms platform NNS cord-006856-b1w25ob5 1376 10 are be VBP cord-006856-b1w25ob5 1376 11 now now RB cord-006856-b1w25ob5 1376 12 becoming become VBG cord-006856-b1w25ob5 1376 13 frequently frequently RB cord-006856-b1w25ob5 1376 14 used use VBN cord-006856-b1w25ob5 1376 15 to to TO cord-006856-b1w25ob5 1376 16 measure measure VB cord-006856-b1w25ob5 1376 17 circulating circulate VBG cord-006856-b1w25ob5 1376 18 drug drug NN cord-006856-b1w25ob5 1376 19 levels level NNS cord-006856-b1w25ob5 1376 20 and and CC cord-006856-b1w25ob5 1376 21 their -PRON- PRP$ cord-006856-b1w25ob5 1376 22 metabolites metabolite NNS cord-006856-b1w25ob5 1376 23 with with IN cord-006856-b1w25ob5 1376 24 lower low JJR cord-006856-b1w25ob5 1376 25 associated associate VBN cord-006856-b1w25ob5 1376 26 costs cost NNS cord-006856-b1w25ob5 1376 27 and and CC cord-006856-b1w25ob5 1376 28 higher high JJR cord-006856-b1w25ob5 1376 29 specificity specificity NN cord-006856-b1w25ob5 1376 30 , , , cord-006856-b1w25ob5 1376 31 accuracy accuracy NN cord-006856-b1w25ob5 1376 32 , , , cord-006856-b1w25ob5 1376 33 and and CC cord-006856-b1w25ob5 1376 34 precision precision NN cord-006856-b1w25ob5 1376 35 . . . cord-006856-b1w25ob5 1377 1 Methods method NNS cord-006856-b1w25ob5 1377 2 . . . cord-006856-b1w25ob5 1378 1 The the DT cord-006856-b1w25ob5 1378 2 setup setup NN cord-006856-b1w25ob5 1378 3 chosen choose VBN cord-006856-b1w25ob5 1378 4 at at IN cord-006856-b1w25ob5 1378 5 our -PRON- PRP$ cord-006856-b1w25ob5 1378 6 laboratories laboratory NNS cord-006856-b1w25ob5 1378 7 consists consist VBZ cord-006856-b1w25ob5 1378 8 of of IN cord-006856-b1w25ob5 1378 9 two two CD cord-006856-b1w25ob5 1378 10 independent independent JJ cord-006856-b1w25ob5 1378 11 mass mass NN cord-006856-b1w25ob5 1378 12 spectrometers spectrometer NNS cord-006856-b1w25ob5 1378 13 ( ( -LRB- cord-006856-b1w25ob5 1378 14 one one CD cord-006856-b1w25ob5 1378 15 machine machine NN cord-006856-b1w25ob5 1378 16 at at IN cord-006856-b1w25ob5 1378 17 the the DT cord-006856-b1w25ob5 1378 18 ZIMCL ZIMCL NNP cord-006856-b1w25ob5 1378 19 , , , cord-006856-b1w25ob5 1378 20 a a DT cord-006856-b1w25ob5 1378 21 backup backup JJ cord-006856-b1w25ob5 1378 22 machine machine NN cord-006856-b1w25ob5 1378 23 at at IN cord-006856-b1w25ob5 1378 24 BIOCRATES BIOCRATES NNP cord-006856-b1w25ob5 1378 25 ) ) -RRB- cord-006856-b1w25ob5 1378 26 and and CC cord-006856-b1w25ob5 1378 27 allows allow VBZ cord-006856-b1w25ob5 1378 28 a a DT cord-006856-b1w25ob5 1378 29 sample sample NN cord-006856-b1w25ob5 1378 30 throughput throughput NN cord-006856-b1w25ob5 1378 31 of of IN cord-006856-b1w25ob5 1378 32 about about RB cord-006856-b1w25ob5 1378 33 25 25 CD cord-006856-b1w25ob5 1378 34 samples sample NNS cord-006856-b1w25ob5 1378 35 per per IN cord-006856-b1w25ob5 1378 36 hour hour NN cord-006856-b1w25ob5 1378 37 . . . cord-006856-b1w25ob5 1379 1 All all DT cord-006856-b1w25ob5 1379 2 immunosup immunosup NNP cord-006856-b1w25ob5 1379 3 - - HYPH cord-006856-b1w25ob5 1379 4 Varia Varia NNP cord-006856-b1w25ob5 1379 5 pressants pressant NNS cord-006856-b1w25ob5 1379 6 currently currently RB cord-006856-b1w25ob5 1379 7 monitored monitor VBN cord-006856-b1w25ob5 1379 8 in in IN cord-006856-b1w25ob5 1379 9 whole whole JJ cord-006856-b1w25ob5 1379 10 blood blood NN cord-006856-b1w25ob5 1379 11 can can MD cord-006856-b1w25ob5 1379 12 be be VB cord-006856-b1w25ob5 1379 13 quantified quantify VBN cord-006856-b1w25ob5 1379 14 within within IN cord-006856-b1w25ob5 1379 15 one one CD cord-006856-b1w25ob5 1379 16 analysis analysis NN cord-006856-b1w25ob5 1379 17 from from IN cord-006856-b1w25ob5 1379 18 a a DT cord-006856-b1w25ob5 1379 19 sample sample NN cord-006856-b1w25ob5 1379 20 volume volume NN cord-006856-b1w25ob5 1379 21 of of IN cord-006856-b1w25ob5 1379 22 less less JJR cord-006856-b1w25ob5 1379 23 than than IN cord-006856-b1w25ob5 1379 24 100 100 CD cord-006856-b1w25ob5 1379 25 µl µl IN cord-006856-b1w25ob5 1379 26 . . . cord-006856-b1w25ob5 1380 1 The the DT cord-006856-b1w25ob5 1380 2 sample sample NN cord-006856-b1w25ob5 1380 3 workup workup NN cord-006856-b1w25ob5 1380 4 ( ( -LRB- cord-006856-b1w25ob5 1380 5 cell cell NN cord-006856-b1w25ob5 1380 6 lysis lysis NN cord-006856-b1w25ob5 1380 7 and and CC cord-006856-b1w25ob5 1380 8 protein protein NN cord-006856-b1w25ob5 1380 9 precipitation precipitation NN cord-006856-b1w25ob5 1380 10 ) ) -RRB- cord-006856-b1w25ob5 1380 11 is be VBZ cord-006856-b1w25ob5 1380 12 performed perform VBN cord-006856-b1w25ob5 1380 13 in in IN cord-006856-b1w25ob5 1380 14 a a DT cord-006856-b1w25ob5 1380 15 bar bar NN cord-006856-b1w25ob5 1380 16 - - HYPH cord-006856-b1w25ob5 1380 17 code code NN cord-006856-b1w25ob5 1380 18 - - HYPH cord-006856-b1w25ob5 1380 19 supported support VBN cord-006856-b1w25ob5 1380 20 parallel parallel JJ cord-006856-b1w25ob5 1380 21 setup setup NN cord-006856-b1w25ob5 1380 22 , , , cord-006856-b1w25ob5 1380 23 minimizing minimize VBG cord-006856-b1w25ob5 1380 24 the the DT cord-006856-b1w25ob5 1380 25 risk risk NN cord-006856-b1w25ob5 1380 26 of of IN cord-006856-b1w25ob5 1380 27 sample sample NN cord-006856-b1w25ob5 1380 28 mix mix NN cord-006856-b1w25ob5 1380 29 - - HYPH cord-006856-b1w25ob5 1380 30 up up NN cord-006856-b1w25ob5 1380 31 . . . cord-006856-b1w25ob5 1381 1 An an DT cord-006856-b1w25ob5 1381 2 online online JJ cord-006856-b1w25ob5 1381 3 solid solid JJ cord-006856-b1w25ob5 1381 4 - - HYPH cord-006856-b1w25ob5 1381 5 phase phase NN cord-006856-b1w25ob5 1381 6 extraction extraction NN cord-006856-b1w25ob5 1381 7 ( ( -LRB- cord-006856-b1w25ob5 1381 8 SPE SPE NNP cord-006856-b1w25ob5 1381 9 ) ) -RRB- cord-006856-b1w25ob5 1381 10 strategy strategy NN cord-006856-b1w25ob5 1381 11 has have VBZ cord-006856-b1w25ob5 1381 12 been be VBN cord-006856-b1w25ob5 1381 13 chosen choose VBN cord-006856-b1w25ob5 1381 14 to to TO cord-006856-b1w25ob5 1381 15 reduce reduce VB cord-006856-b1w25ob5 1381 16 matrix matrix NN cord-006856-b1w25ob5 1381 17 interferences interference NNS cord-006856-b1w25ob5 1381 18 and and CC cord-006856-b1w25ob5 1381 19 ion ion NN cord-006856-b1w25ob5 1381 20 suppression suppression NN cord-006856-b1w25ob5 1381 21 . . . cord-006856-b1w25ob5 1382 1 Daily daily JJ cord-006856-b1w25ob5 1382 2 calibrations calibration NNS cord-006856-b1w25ob5 1382 3 and and CC cord-006856-b1w25ob5 1382 4 quality quality NN cord-006856-b1w25ob5 1382 5 control control NN cord-006856-b1w25ob5 1382 6 samples sample NNS cord-006856-b1w25ob5 1382 7 performed perform VBN cord-006856-b1w25ob5 1382 8 with with IN cord-006856-b1w25ob5 1382 9 certified certified JJ cord-006856-b1w25ob5 1382 10 reference reference NN cord-006856-b1w25ob5 1382 11 materials material NNS cord-006856-b1w25ob5 1382 12 assure assure VBP cord-006856-b1w25ob5 1382 13 a a DT cord-006856-b1w25ob5 1382 14 high high JJ cord-006856-b1w25ob5 1382 15 level level NN cord-006856-b1w25ob5 1382 16 of of IN cord-006856-b1w25ob5 1382 17 accuracy accuracy NN cord-006856-b1w25ob5 1382 18 and and CC cord-006856-b1w25ob5 1382 19 precision precision NN cord-006856-b1w25ob5 1382 20 . . . cord-006856-b1w25ob5 1383 1 Results result NNS cord-006856-b1w25ob5 1383 2 . . . cord-006856-b1w25ob5 1384 1 The the DT cord-006856-b1w25ob5 1384 2 HPLC HPLC NNP cord-006856-b1w25ob5 1384 3 - - HYPH cord-006856-b1w25ob5 1384 4 MS MS NNP cord-006856-b1w25ob5 1384 5 / / SYM cord-006856-b1w25ob5 1384 6 MS MS NNP cord-006856-b1w25ob5 1384 7 assay assay NN cord-006856-b1w25ob5 1384 8 established establish VBN cord-006856-b1w25ob5 1384 9 for for IN cord-006856-b1w25ob5 1384 10 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 1384 11 A A NNP cord-006856-b1w25ob5 1384 12 , , , cord-006856-b1w25ob5 1384 13 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1384 14 , , , cord-006856-b1w25ob5 1384 15 Everolimus Everolimus NNP cord-006856-b1w25ob5 1384 16 , , , cord-006856-b1w25ob5 1384 17 and and CC cord-006856-b1w25ob5 1384 18 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1384 19 covers cover VBZ cord-006856-b1w25ob5 1384 20 the the DT cord-006856-b1w25ob5 1384 21 analyte analyte JJ cord-006856-b1w25ob5 1384 22 concentration concentration NN cord-006856-b1w25ob5 1384 23 range range NN cord-006856-b1w25ob5 1384 24 needed need VBN cord-006856-b1w25ob5 1384 25 for for IN cord-006856-b1w25ob5 1384 26 TDM tdm NN cord-006856-b1w25ob5 1384 27 ( ( -LRB- cord-006856-b1w25ob5 1384 28 e.g. e.g. RB cord-006856-b1w25ob5 1384 29 , , , cord-006856-b1w25ob5 1384 30 up up IN cord-006856-b1w25ob5 1384 31 to to TO cord-006856-b1w25ob5 1384 32 2000 2000 CD cord-006856-b1w25ob5 1384 33 mg mg NN cord-006856-b1w25ob5 1384 34 / / SYM cord-006856-b1w25ob5 1384 35 ml ml XX cord-006856-b1w25ob5 1384 36 for for IN cord-006856-b1w25ob5 1384 37 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 1384 38 A A NNP cord-006856-b1w25ob5 1384 39 ) ) -RRB- cord-006856-b1w25ob5 1384 40 . . . cord-006856-b1w25ob5 1385 1 Intraday Intraday NNP cord-006856-b1w25ob5 1385 2 and and CC cord-006856-b1w25ob5 1385 3 interday interday NN cord-006856-b1w25ob5 1385 4 repeats repeat VBZ cord-006856-b1w25ob5 1385 5 of of IN cord-006856-b1w25ob5 1385 6 the the DT cord-006856-b1w25ob5 1385 7 assay assay NN cord-006856-b1w25ob5 1385 8 and and CC cord-006856-b1w25ob5 1385 9 data datum NNS cord-006856-b1w25ob5 1385 10 from from IN cord-006856-b1w25ob5 1385 11 quality quality NN cord-006856-b1w25ob5 1385 12 control control NN cord-006856-b1w25ob5 1385 13 measurements measurement NNS cord-006856-b1w25ob5 1385 14 were be VBD cord-006856-b1w25ob5 1385 15 sufficiently sufficiently RB cord-006856-b1w25ob5 1385 16 accurate accurate JJ cord-006856-b1w25ob5 1385 17 and and CC cord-006856-b1w25ob5 1385 18 precise precise JJ cord-006856-b1w25ob5 1385 19 ( ( -LRB- cord-006856-b1w25ob5 1385 20 all all DT cord-006856-b1w25ob5 1385 21 CVs cv NNS cord-006856-b1w25ob5 1385 22 , , , cord-006856-b1w25ob5 1385 23 < < XX cord-006856-b1w25ob5 1385 24 15 15 CD cord-006856-b1w25ob5 1385 25 % % NN cord-006856-b1w25ob5 1385 26 ; ; , cord-006856-b1w25ob5 1385 27 bias bias NN cord-006856-b1w25ob5 1385 28 , , , cord-006856-b1w25ob5 1385 29 < < XX cord-006856-b1w25ob5 1385 30 15 15 CD cord-006856-b1w25ob5 1385 31 % % NN cord-006856-b1w25ob5 1385 32 ) ) -RRB- cord-006856-b1w25ob5 1385 33 . . . cord-006856-b1w25ob5 1386 1 Comparison comparison NN cord-006856-b1w25ob5 1386 2 of of IN cord-006856-b1w25ob5 1386 3 the the DT cord-006856-b1w25ob5 1386 4 quantitative quantitative JJ cord-006856-b1w25ob5 1386 5 results result NNS cord-006856-b1w25ob5 1386 6 did do VBD cord-006856-b1w25ob5 1386 7 show show VB cord-006856-b1w25ob5 1386 8 a a DT cord-006856-b1w25ob5 1386 9 linear linear JJ cord-006856-b1w25ob5 1386 10 relationship relationship NN cord-006856-b1w25ob5 1386 11 between between IN cord-006856-b1w25ob5 1386 12 antibody antibody NN cord-006856-b1w25ob5 1386 13 - - HYPH cord-006856-b1w25ob5 1386 14 based base VBN cord-006856-b1w25ob5 1386 15 immunoassays immunoassay NNS cord-006856-b1w25ob5 1386 16 and and CC cord-006856-b1w25ob5 1386 17 the the DT cord-006856-b1w25ob5 1386 18 HPLC HPLC NNP cord-006856-b1w25ob5 1386 19 - - HYPH cord-006856-b1w25ob5 1386 20 MS MS NNP cord-006856-b1w25ob5 1386 21 / / SYM cord-006856-b1w25ob5 1386 22 MS MS NNP cord-006856-b1w25ob5 1386 23 - - HYPH cord-006856-b1w25ob5 1386 24 derived derive VBN cord-006856-b1w25ob5 1386 25 data datum NNS cord-006856-b1w25ob5 1386 26 with with IN cord-006856-b1w25ob5 1386 27 bias bias NN cord-006856-b1w25ob5 1386 28 values value NNS cord-006856-b1w25ob5 1386 29 ( ( -LRB- cord-006856-b1w25ob5 1386 30 ca ca UH cord-006856-b1w25ob5 1386 31 . . . cord-006856-b1w25ob5 1387 1 10 10 CD cord-006856-b1w25ob5 1387 2 % % NN cord-006856-b1w25ob5 1387 3 for for IN cord-006856-b1w25ob5 1387 4 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 1387 5 A A NNP cord-006856-b1w25ob5 1387 6 and and CC cord-006856-b1w25ob5 1387 7 ca ca NN cord-006856-b1w25ob5 1387 8 . . . cord-006856-b1w25ob5 1388 1 30 30 CD cord-006856-b1w25ob5 1388 2 % % NN cord-006856-b1w25ob5 1388 3 for for IN cord-006856-b1w25ob5 1388 4 tacrolimus tacrolimus NN cord-006856-b1w25ob5 1388 5 on on IN cord-006856-b1w25ob5 1388 6 the the DT cord-006856-b1w25ob5 1388 7 basis basis NN cord-006856-b1w25ob5 1388 8 of of IN cord-006856-b1w25ob5 1388 9 Bland Bland NNP cord-006856-b1w25ob5 1388 10 - - HYPH cord-006856-b1w25ob5 1388 11 Altmann Altmann NNP cord-006856-b1w25ob5 1388 12 plots plot NNS cord-006856-b1w25ob5 1388 13 ) ) -RRB- cord-006856-b1w25ob5 1388 14 in in IN cord-006856-b1w25ob5 1388 15 agreement agreement NN cord-006856-b1w25ob5 1388 16 with with IN cord-006856-b1w25ob5 1388 17 the the DT cord-006856-b1w25ob5 1388 18 literature literature NN cord-006856-b1w25ob5 1388 19 . . . cord-006856-b1w25ob5 1389 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1389 2 . . . cord-006856-b1w25ob5 1390 1 The the DT cord-006856-b1w25ob5 1390 2 established establish VBN cord-006856-b1w25ob5 1390 3 HPLC HPLC NNP cord-006856-b1w25ob5 1390 4 - - HYPH cord-006856-b1w25ob5 1390 5 MS MS NNP cord-006856-b1w25ob5 1390 6 / / SYM cord-006856-b1w25ob5 1390 7 MS MS NNP cord-006856-b1w25ob5 1390 8 platform platform NN cord-006856-b1w25ob5 1390 9 will will MD cord-006856-b1w25ob5 1390 10 allow allow VB cord-006856-b1w25ob5 1390 11 replacement replacement NN cord-006856-b1w25ob5 1390 12 of of IN cord-006856-b1w25ob5 1390 13 the the DT cord-006856-b1w25ob5 1390 14 current current JJ cord-006856-b1w25ob5 1390 15 antibody antibody NN cord-006856-b1w25ob5 1390 16 - - HYPH cord-006856-b1w25ob5 1390 17 based base VBN cord-006856-b1w25ob5 1390 18 assays assay NNS cord-006856-b1w25ob5 1390 19 . . . cord-006856-b1w25ob5 1391 1 The the DT cord-006856-b1w25ob5 1391 2 major major JJ cord-006856-b1w25ob5 1391 3 advantage advantage NN cord-006856-b1w25ob5 1391 4 of of IN cord-006856-b1w25ob5 1391 5 this this DT cord-006856-b1w25ob5 1391 6 technique technique NN cord-006856-b1w25ob5 1391 7 is be VBZ cord-006856-b1w25ob5 1391 8 the the DT cord-006856-b1w25ob5 1391 9 ability ability NN cord-006856-b1w25ob5 1391 10 to to TO cord-006856-b1w25ob5 1391 11 simultaneously simultaneously RB cord-006856-b1w25ob5 1391 12 acquire acquire VB cord-006856-b1w25ob5 1391 13 absolute absolute JJ cord-006856-b1w25ob5 1391 14 quantitative quantitative JJ cord-006856-b1w25ob5 1391 15 concentrations concentration NNS cord-006856-b1w25ob5 1391 16 of of IN cord-006856-b1w25ob5 1391 17 each each DT cord-006856-b1w25ob5 1391 18 of of IN cord-006856-b1w25ob5 1391 19 the the DT cord-006856-b1w25ob5 1391 20 therapeutic therapeutic JJ cord-006856-b1w25ob5 1391 21 drugs drug NNS cord-006856-b1w25ob5 1391 22 administered administer VBN cord-006856-b1w25ob5 1391 23 from from IN cord-006856-b1w25ob5 1391 24 one one CD cord-006856-b1w25ob5 1391 25 sample sample NN cord-006856-b1w25ob5 1391 26 . . . cord-006856-b1w25ob5 1392 1 Therefore therefore RB cord-006856-b1w25ob5 1392 2 , , , cord-006856-b1w25ob5 1392 3 the the DT cord-006856-b1w25ob5 1392 4 requirement requirement NN cord-006856-b1w25ob5 1392 5 for for IN cord-006856-b1w25ob5 1392 6 different different JJ cord-006856-b1w25ob5 1392 7 sample sample NN cord-006856-b1w25ob5 1392 8 preparation preparation NN cord-006856-b1w25ob5 1392 9 schemes scheme NNS cord-006856-b1w25ob5 1392 10 or or CC cord-006856-b1w25ob5 1392 11 parallel parallel JJ cord-006856-b1w25ob5 1392 12 measurements measurement NNS cord-006856-b1w25ob5 1392 13 on on IN cord-006856-b1w25ob5 1392 14 different different JJ cord-006856-b1w25ob5 1392 15 analytical analytical JJ cord-006856-b1w25ob5 1392 16 instruments instrument NNS cord-006856-b1w25ob5 1392 17 are be VBP cord-006856-b1w25ob5 1392 18 no no RB cord-006856-b1w25ob5 1392 19 longer long RBR cord-006856-b1w25ob5 1392 20 needed need VBN cord-006856-b1w25ob5 1392 21 . . . cord-006856-b1w25ob5 1393 1 The the DT cord-006856-b1w25ob5 1393 2 high high JJ cord-006856-b1w25ob5 1393 3 sample sample NN cord-006856-b1w25ob5 1393 4 throughput throughput NN cord-006856-b1w25ob5 1393 5 also also RB cord-006856-b1w25ob5 1393 6 assures assure VBZ cord-006856-b1w25ob5 1393 7 timely timely JJ cord-006856-b1w25ob5 1393 8 TDM TDM NNP cord-006856-b1w25ob5 1393 9 data datum NNS cord-006856-b1w25ob5 1393 10 report report NN cord-006856-b1w25ob5 1393 11 to to IN cord-006856-b1w25ob5 1393 12 the the DT cord-006856-b1w25ob5 1393 13 ward ward NN cord-006856-b1w25ob5 1393 14 . . . cord-006856-b1w25ob5 1394 1 A a DT cord-006856-b1w25ob5 1394 2 significant significant JJ cord-006856-b1w25ob5 1394 3 reduction reduction NN cord-006856-b1w25ob5 1394 4 of of IN cord-006856-b1w25ob5 1394 5 costs cost NNS cord-006856-b1w25ob5 1394 6 is be VBZ cord-006856-b1w25ob5 1394 7 now now RB cord-006856-b1w25ob5 1394 8 expected expect VBN cord-006856-b1w25ob5 1394 9 due due IN cord-006856-b1w25ob5 1394 10 to to IN cord-006856-b1w25ob5 1394 11 the the DT cord-006856-b1w25ob5 1394 12 lower low JJR cord-006856-b1w25ob5 1394 13 consumable consumable JJ cord-006856-b1w25ob5 1394 14 expenses expense NNS cord-006856-b1w25ob5 1394 15 in in IN cord-006856-b1w25ob5 1394 16 HPLC HPLC NNP cord-006856-b1w25ob5 1394 17 - - HYPH cord-006856-b1w25ob5 1394 18 MS MS NNP cord-006856-b1w25ob5 1394 19 / / SYM cord-006856-b1w25ob5 1394 20 MS MS NNP cord-006856-b1w25ob5 1394 21 assays assay NNS cord-006856-b1w25ob5 1394 22 . . . cord-006856-b1w25ob5 1395 1 Background background NN cord-006856-b1w25ob5 1395 2 . . . cord-006856-b1w25ob5 1396 1 A a DT cord-006856-b1w25ob5 1396 2 clinical clinical JJ cord-006856-b1w25ob5 1396 3 trial trial NN cord-006856-b1w25ob5 1396 4 towards towards IN cord-006856-b1w25ob5 1396 5 improved improved JJ cord-006856-b1w25ob5 1396 6 safety safety NN cord-006856-b1w25ob5 1396 7 of of IN cord-006856-b1w25ob5 1396 8 the the DT cord-006856-b1w25ob5 1396 9 application application NN cord-006856-b1w25ob5 1396 10 of of IN cord-006856-b1w25ob5 1396 11 Everolimus Everolimus NNP cord-006856-b1w25ob5 1396 12 ( ( -LRB- cord-006856-b1w25ob5 1396 13 Certican Certican NNP cord-006856-b1w25ob5 1396 14 ) ) -RRB- cord-006856-b1w25ob5 1396 15 in in IN cord-006856-b1w25ob5 1396 16 heart heart NN cord-006856-b1w25ob5 1396 17 transplantations transplantation NNS cord-006856-b1w25ob5 1396 18 ( ( -LRB- cord-006856-b1w25ob5 1396 19 CRAD001A2403 CRAD001A2403 NNP cord-006856-b1w25ob5 1396 20 , , , cord-006856-b1w25ob5 1396 21 data datum NNS cord-006856-b1w25ob5 1396 22 collection collection NN cord-006856-b1w25ob5 1396 23 started start VBD cord-006856-b1w25ob5 1396 24 in in IN cord-006856-b1w25ob5 1396 25 August August NNP cord-006856-b1w25ob5 1396 26 2004 2004 CD cord-006856-b1w25ob5 1396 27 and and CC cord-006856-b1w25ob5 1396 28 is be VBZ cord-006856-b1w25ob5 1396 29 ongoing ongoing JJ cord-006856-b1w25ob5 1396 30 ) ) -RRB- cord-006856-b1w25ob5 1396 31 allowed allow VBD cord-006856-b1w25ob5 1396 32 us -PRON- PRP cord-006856-b1w25ob5 1396 33 to to TO cord-006856-b1w25ob5 1396 34 compare compare VB cord-006856-b1w25ob5 1396 35 therapeutic therapeutic JJ cord-006856-b1w25ob5 1396 36 drug drug NN cord-006856-b1w25ob5 1396 37 monitoring monitoring NN cord-006856-b1w25ob5 1396 38 ( ( -LRB- cord-006856-b1w25ob5 1396 39 TDM TDM NNP cord-006856-b1w25ob5 1396 40 ) ) -RRB- cord-006856-b1w25ob5 1396 41 data data NN cord-006856-b1w25ob5 1396 42 ( ( -LRB- cord-006856-b1w25ob5 1396 43 E0 E0 NNP cord-006856-b1w25ob5 1396 44 and and CC cord-006856-b1w25ob5 1396 45 E2 E2 NNP cord-006856-b1w25ob5 1396 46 levels level NNS cord-006856-b1w25ob5 1396 47 ) ) -RRB- cord-006856-b1w25ob5 1396 48 measured measure VBD cord-006856-b1w25ob5 1396 49 on on IN cord-006856-b1w25ob5 1396 50 two two CD cord-006856-b1w25ob5 1396 51 different different JJ cord-006856-b1w25ob5 1396 52 platforms platform NNS cord-006856-b1w25ob5 1396 53 -an -an . cord-006856-b1w25ob5 1397 1 LC LC NNP cord-006856-b1w25ob5 1397 2 - - HYPH cord-006856-b1w25ob5 1397 3 MS MS NNP cord-006856-b1w25ob5 1397 4 / / SYM cord-006856-b1w25ob5 1397 5 MS MS NNP cord-006856-b1w25ob5 1397 6 method method NN cord-006856-b1w25ob5 1397 7 in in IN cord-006856-b1w25ob5 1397 8 an an DT cord-006856-b1w25ob5 1397 9 external external JJ cord-006856-b1w25ob5 1397 10 laboratory laboratory NN cord-006856-b1w25ob5 1397 11 and and CC cord-006856-b1w25ob5 1397 12 a a DT cord-006856-b1w25ob5 1397 13 immunochemical immunochemical JJ cord-006856-b1w25ob5 1397 14 method method NN cord-006856-b1w25ob5 1397 15 recently recently RB cord-006856-b1w25ob5 1397 16 established establish VBN cord-006856-b1w25ob5 1397 17 at at IN cord-006856-b1w25ob5 1397 18 our -PRON- PRP$ cord-006856-b1w25ob5 1397 19 institute institute NN cord-006856-b1w25ob5 1397 20 . . . cord-006856-b1w25ob5 1398 1 Methods method NNS cord-006856-b1w25ob5 1398 2 . . . cord-006856-b1w25ob5 1399 1 LC LC NNP cord-006856-b1w25ob5 1399 2 - - HYPH cord-006856-b1w25ob5 1399 3 MS MS NNP cord-006856-b1w25ob5 1399 4 / / SYM cord-006856-b1w25ob5 1399 5 MS MS NNP cord-006856-b1w25ob5 1399 6 measurements measurement NNS cord-006856-b1w25ob5 1399 7 of of IN cord-006856-b1w25ob5 1399 8 Everolimus Everolimus NNP cord-006856-b1w25ob5 1399 9 were be VBD cord-006856-b1w25ob5 1399 10 performed perform VBN cord-006856-b1w25ob5 1399 11 in in IN cord-006856-b1w25ob5 1399 12 a a DT cord-006856-b1w25ob5 1399 13 reference reference NN cord-006856-b1w25ob5 1399 14 laboratory laboratory NN cord-006856-b1w25ob5 1399 15 . . . cord-006856-b1w25ob5 1400 1 The the DT cord-006856-b1w25ob5 1400 2 immunochemical immunochemical JJ cord-006856-b1w25ob5 1400 3 measurements measurement NNS cord-006856-b1w25ob5 1400 4 were be VBD cord-006856-b1w25ob5 1400 5 performed perform VBN cord-006856-b1w25ob5 1400 6 with with IN cord-006856-b1w25ob5 1400 7 a a DT cord-006856-b1w25ob5 1400 8 fluorescence fluorescence NN cord-006856-b1w25ob5 1400 9 polarization polarization NN cord-006856-b1w25ob5 1400 10 immunoassay immunoassay NN cord-006856-b1w25ob5 1400 11 ( ( -LRB- cord-006856-b1w25ob5 1400 12 Innofluor Innofluor NNP cord-006856-b1w25ob5 1400 13 Certican Certican NNP cord-006856-b1w25ob5 1400 14 immunoassay immunoassay NN cord-006856-b1w25ob5 1400 15 by by IN cord-006856-b1w25ob5 1400 16 Seradyn Seradyn NNP cord-006856-b1w25ob5 1400 17 ) ) -RRB- cord-006856-b1w25ob5 1400 18 measured measure VBD cord-006856-b1w25ob5 1400 19 on on IN cord-006856-b1w25ob5 1400 20 a a DT cord-006856-b1w25ob5 1400 21 TDX TDX NNP cord-006856-b1w25ob5 1400 22 instrument instrument NN cord-006856-b1w25ob5 1400 23 from from IN cord-006856-b1w25ob5 1400 24 Abbott Abbott NNP cord-006856-b1w25ob5 1400 25 . . . cord-006856-b1w25ob5 1401 1 Method method NN cord-006856-b1w25ob5 1401 2 comparison comparison NN cord-006856-b1w25ob5 1401 3 included include VBD cord-006856-b1w25ob5 1401 4 analysis analysis NN cord-006856-b1w25ob5 1401 5 of of IN cord-006856-b1w25ob5 1401 6 the the DT cord-006856-b1w25ob5 1401 7 time time NN cord-006856-b1w25ob5 1401 8 series series NN cord-006856-b1w25ob5 1401 9 of of IN cord-006856-b1w25ob5 1401 10 the the DT cord-006856-b1w25ob5 1401 11 patients patient NNS cord-006856-b1w25ob5 1401 12 ( ( -LRB- cord-006856-b1w25ob5 1401 13 n n NN cord-006856-b1w25ob5 1401 14 = = SYM cord-006856-b1w25ob5 1401 15 7 7 CD cord-006856-b1w25ob5 1401 16 , , , cord-006856-b1w25ob5 1401 17 65 65 CD cord-006856-b1w25ob5 1401 18 observation observation NN cord-006856-b1w25ob5 1401 19 pairs pair NNS cord-006856-b1w25ob5 1401 20 ) ) -RRB- cord-006856-b1w25ob5 1401 21 and and CC cord-006856-b1w25ob5 1401 22 the the DT cord-006856-b1w25ob5 1401 23 quality quality NN cord-006856-b1w25ob5 1401 24 control control NN cord-006856-b1w25ob5 1401 25 samples sample NNS cord-006856-b1w25ob5 1401 26 of of IN cord-006856-b1w25ob5 1401 27 the the DT cord-006856-b1w25ob5 1401 28 immunochemical immunochemical JJ cord-006856-b1w25ob5 1401 29 assay assay NN cord-006856-b1w25ob5 1401 30 gathered gather VBD cord-006856-b1w25ob5 1401 31 over over IN cord-006856-b1w25ob5 1401 32 a a DT cord-006856-b1w25ob5 1401 33 year year NN cord-006856-b1w25ob5 1401 34 as as RB cord-006856-b1w25ob5 1401 35 well well RB cord-006856-b1w25ob5 1401 36 as as IN cord-006856-b1w25ob5 1401 37 inter inter JJ cord-006856-b1w25ob5 1401 38 - - JJ cord-006856-b1w25ob5 1401 39 and and CC cord-006856-b1w25ob5 1401 40 intra intra JJ cord-006856-b1w25ob5 1401 41 - - JJ cord-006856-b1w25ob5 1401 42 assay assay JJ cord-006856-b1w25ob5 1401 43 data datum NNS cord-006856-b1w25ob5 1401 44 comparisons comparison NNS cord-006856-b1w25ob5 1401 45 based base VBN cord-006856-b1w25ob5 1401 46 on on IN cord-006856-b1w25ob5 1401 47 Bland Bland NNP cord-006856-b1w25ob5 1401 48 - - HYPH cord-006856-b1w25ob5 1401 49 Altmann Altmann NNP cord-006856-b1w25ob5 1401 50 plots plot NNS cord-006856-b1w25ob5 1401 51 and and CC cord-006856-b1w25ob5 1401 52 regression regression NN cord-006856-b1w25ob5 1401 53 data datum NNS cord-006856-b1w25ob5 1401 54 . . . cord-006856-b1w25ob5 1402 1 Results result NNS cord-006856-b1w25ob5 1402 2 . . . cord-006856-b1w25ob5 1403 1 Comparison comparison NN cord-006856-b1w25ob5 1403 2 of of IN cord-006856-b1w25ob5 1403 3 the the DT cord-006856-b1w25ob5 1403 4 quantitative quantitative JJ cord-006856-b1w25ob5 1403 5 results result NNS cord-006856-b1w25ob5 1403 6 obtained obtain VBN cord-006856-b1w25ob5 1403 7 from from IN cord-006856-b1w25ob5 1403 8 the the DT cord-006856-b1w25ob5 1403 9 LC LC NNP cord-006856-b1w25ob5 1403 10 - - HYPH cord-006856-b1w25ob5 1403 11 MS MS NNP cord-006856-b1w25ob5 1403 12 / / SYM cord-006856-b1w25ob5 1403 13 MS MS NNP cord-006856-b1w25ob5 1403 14 and and CC cord-006856-b1w25ob5 1403 15 the the DT cord-006856-b1w25ob5 1403 16 immunochemical immunochemical JJ cord-006856-b1w25ob5 1403 17 assay assay NN cord-006856-b1w25ob5 1403 18 showed show VBD cord-006856-b1w25ob5 1403 19 good good JJ cord-006856-b1w25ob5 1403 20 agreement agreement NN cord-006856-b1w25ob5 1403 21 between between IN cord-006856-b1w25ob5 1403 22 these these DT cord-006856-b1w25ob5 1403 23 methods method NNS cord-006856-b1w25ob5 1403 24 . . . cord-006856-b1w25ob5 1404 1 The the DT cord-006856-b1w25ob5 1404 2 bias bias NN cord-006856-b1w25ob5 1404 3 between between IN cord-006856-b1w25ob5 1404 4 the the DT cord-006856-b1w25ob5 1404 5 methods method NNS cord-006856-b1w25ob5 1404 6 ( ( -LRB- cord-006856-b1w25ob5 1404 7 Bland Bland NNP cord-006856-b1w25ob5 1404 8 - - HYPH cord-006856-b1w25ob5 1404 9 Altmann Altmann NNP cord-006856-b1w25ob5 1404 10 plot plot NN cord-006856-b1w25ob5 1404 11 ) ) -RRB- cord-006856-b1w25ob5 1404 12 was be VBD cord-006856-b1w25ob5 1404 13 found find VBN cord-006856-b1w25ob5 1404 14 to to TO cord-006856-b1w25ob5 1404 15 be be VB cord-006856-b1w25ob5 1404 16 rather rather RB cord-006856-b1w25ob5 1404 17 small small JJ cord-006856-b1w25ob5 1404 18 , , , cord-006856-b1w25ob5 1404 19 with with IN cord-006856-b1w25ob5 1404 20 the the DT cord-006856-b1w25ob5 1404 21 immunochemical immunochemical JJ cord-006856-b1w25ob5 1404 22 method method NN cord-006856-b1w25ob5 1404 23 measuring measure VBG cord-006856-b1w25ob5 1404 24 in in IN cord-006856-b1w25ob5 1404 25 average average JJ cord-006856-b1w25ob5 1404 26 approximately approximately RB cord-006856-b1w25ob5 1404 27 5 5 CD cord-006856-b1w25ob5 1404 28 % % NN cord-006856-b1w25ob5 1404 29 ( ( -LRB- cord-006856-b1w25ob5 1404 30 ±25 ±25 NNP cord-006856-b1w25ob5 1404 31 % % NN cord-006856-b1w25ob5 1404 32 ) ) -RRB- cord-006856-b1w25ob5 1404 33 lower low JJR cord-006856-b1w25ob5 1404 34 values value NNS cord-006856-b1w25ob5 1404 35 as as IN cord-006856-b1w25ob5 1404 36 the the DT cord-006856-b1w25ob5 1404 37 LC LC NNP cord-006856-b1w25ob5 1404 38 - - HYPH cord-006856-b1w25ob5 1404 39 MS MS NNP cord-006856-b1w25ob5 1404 40 / / SYM cord-006856-b1w25ob5 1404 41 MS MS NNP cord-006856-b1w25ob5 1404 42 method method NN cord-006856-b1w25ob5 1404 43 , , , cord-006856-b1w25ob5 1404 44 which which WDT cord-006856-b1w25ob5 1404 45 is be VBZ cord-006856-b1w25ob5 1404 46 in in IN cord-006856-b1w25ob5 1404 47 good good JJ cord-006856-b1w25ob5 1404 48 agreement agreement NN cord-006856-b1w25ob5 1404 49 with with IN cord-006856-b1w25ob5 1404 50 current current JJ cord-006856-b1w25ob5 1404 51 reports report NNS cord-006856-b1w25ob5 1404 52 . . . cord-006856-b1w25ob5 1405 1 The the DT cord-006856-b1w25ob5 1405 2 coefficient coefficient NN cord-006856-b1w25ob5 1405 3 of of IN cord-006856-b1w25ob5 1405 4 variation variation NN cord-006856-b1w25ob5 1405 5 ( ( -LRB- cord-006856-b1w25ob5 1405 6 CV cv NN cord-006856-b1w25ob5 1405 7 ) ) -RRB- cord-006856-b1w25ob5 1405 8 ( ( -LRB- cord-006856-b1w25ob5 1405 9 measured measure VBN cord-006856-b1w25ob5 1405 10 over over IN cord-006856-b1w25ob5 1405 11 several several JJ cord-006856-b1w25ob5 1405 12 months month NNS cord-006856-b1w25ob5 1405 13 ) ) -RRB- cord-006856-b1w25ob5 1405 14 of of IN cord-006856-b1w25ob5 1405 15 the the DT cord-006856-b1w25ob5 1405 16 Innofluor Innofluor NNP cord-006856-b1w25ob5 1405 17 quality quality NN cord-006856-b1w25ob5 1405 18 control control NN cord-006856-b1w25ob5 1405 19 measurements measurement NNS cord-006856-b1w25ob5 1405 20 was be VBD cord-006856-b1w25ob5 1405 21 < < NNP cord-006856-b1w25ob5 1405 22 7 7 CD cord-006856-b1w25ob5 1405 23 % % NN cord-006856-b1w25ob5 1405 24 for for IN cord-006856-b1w25ob5 1405 25 the the DT cord-006856-b1w25ob5 1405 26 medium medium NN cord-006856-b1w25ob5 1405 27 ( ( -LRB- cord-006856-b1w25ob5 1405 28 ca ca NN cord-006856-b1w25ob5 1405 29 . . . cord-006856-b1w25ob5 1406 1 12 12 CD cord-006856-b1w25ob5 1406 2 ng ng NNP cord-006856-b1w25ob5 1406 3 / / SYM cord-006856-b1w25ob5 1406 4 ml ml NN cord-006856-b1w25ob5 1406 5 ) ) -RRB- cord-006856-b1w25ob5 1406 6 and and CC cord-006856-b1w25ob5 1406 7 high high JJ cord-006856-b1w25ob5 1406 8 ( ( -LRB- cord-006856-b1w25ob5 1406 9 ca ca NN cord-006856-b1w25ob5 1406 10 . . . cord-006856-b1w25ob5 1407 1 25 25 CD cord-006856-b1w25ob5 1408 1 ng ng NNP cord-006856-b1w25ob5 1408 2 / / SYM cord-006856-b1w25ob5 1408 3 ml ml NN cord-006856-b1w25ob5 1408 4 ) ) -RRB- cord-006856-b1w25ob5 1408 5 quality quality NN cord-006856-b1w25ob5 1408 6 control control NN cord-006856-b1w25ob5 1408 7 samples sample NNS cord-006856-b1w25ob5 1408 8 , , , cord-006856-b1w25ob5 1408 9 whereas whereas IN cord-006856-b1w25ob5 1408 10 the the DT cord-006856-b1w25ob5 1408 11 lower low JJR cord-006856-b1w25ob5 1408 12 quality quality NN cord-006856-b1w25ob5 1408 13 control control NN cord-006856-b1w25ob5 1408 14 level level NN cord-006856-b1w25ob5 1408 15 ( ( -LRB- cord-006856-b1w25ob5 1408 16 ca ca NN cord-006856-b1w25ob5 1408 17 . . . cord-006856-b1w25ob5 1409 1 4.5 4.5 CD cord-006856-b1w25ob5 1409 2 ng ng NNP cord-006856-b1w25ob5 1409 3 / / SYM cord-006856-b1w25ob5 1409 4 ml ml NN cord-006856-b1w25ob5 1409 5 ) ) -RRB- cord-006856-b1w25ob5 1409 6 showed show VBD cord-006856-b1w25ob5 1409 7 an an DT cord-006856-b1w25ob5 1409 8 increased increase VBN cord-006856-b1w25ob5 1409 9 CV cv NN cord-006856-b1w25ob5 1409 10 ( ( -LRB- cord-006856-b1w25ob5 1409 11 < < NNP cord-006856-b1w25ob5 1409 12 13 13 CD cord-006856-b1w25ob5 1409 13 % % NN cord-006856-b1w25ob5 1409 14 ) ) -RRB- cord-006856-b1w25ob5 1409 15 . . . cord-006856-b1w25ob5 1410 1 However however RB cord-006856-b1w25ob5 1410 2 , , , cord-006856-b1w25ob5 1410 3 especially especially RB cord-006856-b1w25ob5 1410 4 during during IN cord-006856-b1w25ob5 1410 5 the the DT cord-006856-b1w25ob5 1410 6 phase phase NN cord-006856-b1w25ob5 1410 7 of of IN cord-006856-b1w25ob5 1410 8 method method NN cord-006856-b1w25ob5 1410 9 establishment establishment NN cord-006856-b1w25ob5 1410 10 , , , cord-006856-b1w25ob5 1410 11 higher high JJR cord-006856-b1w25ob5 1410 12 CV cv NN cord-006856-b1w25ob5 1410 13 values value NNS cord-006856-b1w25ob5 1410 14 and and CC cord-006856-b1w25ob5 1410 15 bias bias NN cord-006856-b1w25ob5 1410 16 deviations deviation NNS cord-006856-b1w25ob5 1410 17 have have VBP cord-006856-b1w25ob5 1410 18 been be VBN cord-006856-b1w25ob5 1410 19 found find VBN cord-006856-b1w25ob5 1410 20 Conclusions conclusion NNS cord-006856-b1w25ob5 1410 21 . . . cord-006856-b1w25ob5 1411 1 The the DT cord-006856-b1w25ob5 1411 2 method method NN cord-006856-b1w25ob5 1411 3 comparison comparison NN cord-006856-b1w25ob5 1411 4 did do VBD cord-006856-b1w25ob5 1411 5 show show VB cord-006856-b1w25ob5 1411 6 that that IN cord-006856-b1w25ob5 1411 7 the the DT cord-006856-b1w25ob5 1411 8 immunochemical immunochemical JJ cord-006856-b1w25ob5 1411 9 Everolimus Everolimus NNP cord-006856-b1w25ob5 1411 10 assay assay NN cord-006856-b1w25ob5 1411 11 provided provide VBN cord-006856-b1w25ob5 1411 12 by by IN cord-006856-b1w25ob5 1411 13 Seradyn Seradyn NNP cord-006856-b1w25ob5 1411 14 is be VBZ cord-006856-b1w25ob5 1411 15 a a DT cord-006856-b1w25ob5 1411 16 good good JJ cord-006856-b1w25ob5 1411 17 alternative alternative NN cord-006856-b1w25ob5 1411 18 to to IN cord-006856-b1w25ob5 1411 19 HPLC HPLC NNP cord-006856-b1w25ob5 1411 20 - - HYPH cord-006856-b1w25ob5 1411 21 MS MS NNP cord-006856-b1w25ob5 1411 22 / / SYM cord-006856-b1w25ob5 1411 23 MS MS NNP cord-006856-b1w25ob5 1411 24 measurements measurement NNS cord-006856-b1w25ob5 1411 25 . . . cord-006856-b1w25ob5 1412 1 The the DT cord-006856-b1w25ob5 1412 2 assay assay NN cord-006856-b1w25ob5 1412 3 bias bias NN cord-006856-b1w25ob5 1412 4 was be VBD cord-006856-b1w25ob5 1412 5 found find VBN cord-006856-b1w25ob5 1412 6 to to TO cord-006856-b1w25ob5 1412 7 be be VB cord-006856-b1w25ob5 1412 8 rather rather RB cord-006856-b1w25ob5 1412 9 low low JJ cord-006856-b1w25ob5 1412 10 and and CC cord-006856-b1w25ob5 1412 11 the the DT cord-006856-b1w25ob5 1412 12 assay assay NN cord-006856-b1w25ob5 1412 13 uncertainty uncertainty NN cord-006856-b1w25ob5 1412 14 was be VBD cord-006856-b1w25ob5 1412 15 within within IN cord-006856-b1w25ob5 1412 16 acceptable acceptable JJ cord-006856-b1w25ob5 1412 17 ranges range NNS cord-006856-b1w25ob5 1412 18 . . . cord-006856-b1w25ob5 1413 1 However however RB cord-006856-b1w25ob5 1413 2 , , , cord-006856-b1w25ob5 1413 3 a a DT cord-006856-b1w25ob5 1413 4 stringent stringent JJ cord-006856-b1w25ob5 1413 5 quality quality NN cord-006856-b1w25ob5 1413 6 control control NN cord-006856-b1w25ob5 1413 7 network network NN cord-006856-b1w25ob5 1413 8 must must MD cord-006856-b1w25ob5 1413 9 be be VB cord-006856-b1w25ob5 1413 10 provided provide VBN cord-006856-b1w25ob5 1413 11 to to TO cord-006856-b1w25ob5 1413 12 assure assure VB cord-006856-b1w25ob5 1413 13 stable stable JJ cord-006856-b1w25ob5 1413 14 assay assay NN cord-006856-b1w25ob5 1413 15 performance performance NN cord-006856-b1w25ob5 1413 16 over over IN cord-006856-b1w25ob5 1413 17 time time NN cord-006856-b1w25ob5 1413 18 . . . cord-006856-b1w25ob5 1414 1 Grundlagen Grundlagen NNP cord-006856-b1w25ob5 1414 2 . . . cord-006856-b1w25ob5 1415 1 Die die VB cord-006856-b1w25ob5 1415 2 Inzidenz Inzidenz NNP cord-006856-b1w25ob5 1415 3 der der NNP cord-006856-b1w25ob5 1415 4 Endokarditis Endokarditis NNP cord-006856-b1w25ob5 1415 5 beträgt beträgt NN cord-006856-b1w25ob5 1415 6 ca ca NN cord-006856-b1w25ob5 1415 7 . . . cord-006856-b1w25ob5 1416 1 6/100 6/100 CD cord-006856-b1w25ob5 1416 2 000 000 CD cord-006856-b1w25ob5 1416 3 Einwohner Einwohner NNP cord-006856-b1w25ob5 1416 4 pro pro JJ cord-006856-b1w25ob5 1416 5 Jahr Jahr NNP cord-006856-b1w25ob5 1416 6 in in IN cord-006856-b1w25ob5 1416 7 der der NNP cord-006856-b1w25ob5 1416 8 Gesamtbevölkerung Gesamtbevölkerung NNP cord-006856-b1w25ob5 1416 9 . . . cord-006856-b1w25ob5 1417 1 Obwohl Obwohl NNP cord-006856-b1w25ob5 1417 2 die die VBP cord-006856-b1w25ob5 1417 3 Immunsuppression Immunsuppression NNP cord-006856-b1w25ob5 1417 4 das das NNP cord-006856-b1w25ob5 1417 5 Auftreten Auftreten NNP cord-006856-b1w25ob5 1417 6 systemischer systemischer NN cord-006856-b1w25ob5 1418 1 Infektionen Infektionen NNP cord-006856-b1w25ob5 1418 2 begünstigt begünstigt NNP cord-006856-b1w25ob5 1418 3 , , , cord-006856-b1w25ob5 1418 4 sind sind NNP cord-006856-b1w25ob5 1418 5 Endokarditisstudien Endokarditisstudien NNP cord-006856-b1w25ob5 1418 6 an an DT cord-006856-b1w25ob5 1418 7 Transplantationsempfängern Transplantationsempfängern NNP cord-006856-b1w25ob5 1418 8 nicht nicht NNP cord-006856-b1w25ob5 1418 9 verfügbar verfügbar NN cord-006856-b1w25ob5 1418 10 . . . cord-006856-b1w25ob5 1419 1 Ziel Ziel NNP cord-006856-b1w25ob5 1419 2 dieser dieser NNP cord-006856-b1w25ob5 1419 3 epidemiologischen epidemiologischen NNP cord-006856-b1w25ob5 1419 4 Studie Studie NNP cord-006856-b1w25ob5 1419 5 war war NN cord-006856-b1w25ob5 1419 6 , , , cord-006856-b1w25ob5 1419 7 das das NNP cord-006856-b1w25ob5 1419 8 Auftreten Auftreten NNP cord-006856-b1w25ob5 1419 9 der der NNP cord-006856-b1w25ob5 1419 10 Endokarditis Endokarditis NNP cord-006856-b1w25ob5 1419 11 und und VBD cord-006856-b1w25ob5 1419 12 ihrer ihrer JJ cord-006856-b1w25ob5 1419 13 Risikofaktoren Risikofaktoren NNP cord-006856-b1w25ob5 1419 14 nach nach NN cord-006856-b1w25ob5 1419 15 Organtransplantation Organtransplantation NNP cord-006856-b1w25ob5 1419 16 zu zu NNP cord-006856-b1w25ob5 1419 17 evaluieren evaluieren NN cord-006856-b1w25ob5 1419 18 . . . cord-006856-b1w25ob5 1420 1 Methodik Methodik NNP cord-006856-b1w25ob5 1420 2 . . . cord-006856-b1w25ob5 1421 1 Insgesamt Insgesamt NNP cord-006856-b1w25ob5 1421 2 2556 2556 CD cord-006856-b1w25ob5 1421 3 Patienten Patienten NNP cord-006856-b1w25ob5 1421 4 , , , cord-006856-b1w25ob5 1421 5 welche welche NNP cord-006856-b1w25ob5 1421 6 sich sich NNP cord-006856-b1w25ob5 1421 7 zwischen zwischen NNP cord-006856-b1w25ob5 1421 8 1989 1989 CD cord-006856-b1w25ob5 1421 9 und und NNP cord-006856-b1w25ob5 1421 10 2004 2004 CD cord-006856-b1w25ob5 1421 11 einer einer NNP cord-006856-b1w25ob5 1421 12 soliden soliden NNP cord-006856-b1w25ob5 1421 13 Organtransplantation Organtransplantation NNP cord-006856-b1w25ob5 1422 1 an an DT cord-006856-b1w25ob5 1422 2 unserem unserem JJ cord-006856-b1w25ob5 1422 3 Zentrum Zentrum NNP cord-006856-b1w25ob5 1422 4 unterzogen unterzogen NNP cord-006856-b1w25ob5 1422 5 , , , cord-006856-b1w25ob5 1422 6 wurden wurden NNP cord-006856-b1w25ob5 1422 7 untersucht untersucht NNP cord-006856-b1w25ob5 1422 8 . . . cord-006856-b1w25ob5 1423 1 Der Der NNP cord-006856-b1w25ob5 1423 2 MBDS MBDS NNP cord-006856-b1w25ob5 1423 3 unserer unserer JJ cord-006856-b1w25ob5 1423 4 Klinik Klinik NNP cord-006856-b1w25ob5 1423 5 wurde wurde NN cord-006856-b1w25ob5 1423 6 zum zum NNP cord-006856-b1w25ob5 1423 7 Patientenscreening Patientenscreening NNP cord-006856-b1w25ob5 1423 8 herangezogen herangezogen NNP cord-006856-b1w25ob5 1423 9 . . . cord-006856-b1w25ob5 1424 1 Ergebnisse Ergebnisse NNP cord-006856-b1w25ob5 1424 2 . . . cord-006856-b1w25ob5 1425 1 Insgesamt Insgesamt NNP cord-006856-b1w25ob5 1425 2 wurden wurden NNP cord-006856-b1w25ob5 1426 1 i -PRON- PRP cord-006856-b1w25ob5 1426 2 m be VBP cord-006856-b1w25ob5 1426 3 Beobachtungszeitraum Beobachtungszeitraum NNP cord-006856-b1w25ob5 1426 4 27 27 CD cord-006856-b1w25ob5 1426 5 Endokarditisfälle Endokarditisfälle NNP cord-006856-b1w25ob5 1426 6 beobachtet beobachtet NNP cord-006856-b1w25ob5 1426 7 . . . cord-006856-b1w25ob5 1427 1 Neun Neun NNP cord-006856-b1w25ob5 1427 2 Endokarditisfälle Endokarditisfälle NNP cord-006856-b1w25ob5 1427 3 ( ( -LRB- cord-006856-b1w25ob5 1427 4 33,3 33,3 CD cord-006856-b1w25ob5 1427 5 % % NN cord-006856-b1w25ob5 1427 6 ) ) -RRB- cord-006856-b1w25ob5 1428 1 konnten konnten NNP cord-006856-b1w25ob5 1428 2 erst erst NNP cord-006856-b1w25ob5 1428 3 post post AFX cord-006856-b1w25ob5 1428 4 mortem mortem FW cord-006856-b1w25ob5 1428 5 mittels mittels NNP cord-006856-b1w25ob5 1428 6 Autopsie Autopsie NNP cord-006856-b1w25ob5 1428 7 diagnostiziert diagnostiziert NNP cord-006856-b1w25ob5 1428 8 werden werden NNP cord-006856-b1w25ob5 1428 9 , , , cord-006856-b1w25ob5 1429 1 8 8 CD cord-006856-b1w25ob5 1429 2 Patienten Patienten NNP cord-006856-b1w25ob5 1429 3 ( ( -LRB- cord-006856-b1w25ob5 1429 4 29,6 29,6 CD cord-006856-b1w25ob5 1429 5 % % NN cord-006856-b1w25ob5 1429 6 ) ) -RRB- cord-006856-b1w25ob5 1429 7 konnten konnten NNP cord-006856-b1w25ob5 1429 8 durch durch NNP cord-006856-b1w25ob5 1429 9 alleinige alleinige NNP cord-006856-b1w25ob5 1429 10 antibiotische antibiotische NNP cord-006856-b1w25ob5 1429 11 Therapie Therapie NNP cord-006856-b1w25ob5 1429 12 geheilt geheilt NNP cord-006856-b1w25ob5 1429 13 werden werden NNP cord-006856-b1w25ob5 1429 14 . . . cord-006856-b1w25ob5 1430 1 Insgesamt Insgesamt NNP cord-006856-b1w25ob5 1430 2 10 10 CD cord-006856-b1w25ob5 1430 3 Transplantationsempfänger Transplantationsempfänger NNP cord-006856-b1w25ob5 1430 4 ( ( -LRB- cord-006856-b1w25ob5 1430 5 37,1 37,1 CD cord-006856-b1w25ob5 1430 6 % % NN cord-006856-b1w25ob5 1430 7 ) ) -RRB- cord-006856-b1w25ob5 1430 8 mussten mussten NNP cord-006856-b1w25ob5 1430 9 sich sich NNP cord-006856-b1w25ob5 1430 10 einem einem NNP cord-006856-b1w25ob5 1430 11 kardiochirurgischen kardiochirurgischen NNP cord-006856-b1w25ob5 1430 12 Eingriff Eingriff NNP cord-006856-b1w25ob5 1430 13 unterziehen unterziehen NN cord-006856-b1w25ob5 1430 14 . . . cord-006856-b1w25ob5 1431 1 Die die VB cord-006856-b1w25ob5 1431 2 Gesamtmortalität Gesamtmortalität NNP cord-006856-b1w25ob5 1431 3 betrug betrug NNP cord-006856-b1w25ob5 1431 4 44,4 44,4 CD cord-006856-b1w25ob5 1431 5 % % NN cord-006856-b1w25ob5 1431 6 ( ( -LRB- cord-006856-b1w25ob5 1431 7 12 12 CD cord-006856-b1w25ob5 1431 8 Patienten Patienten NNP cord-006856-b1w25ob5 1431 9 ) ) -RRB- cord-006856-b1w25ob5 1431 10 . . . cord-006856-b1w25ob5 1432 1 Staphylococcus Staphylococcus NNP cord-006856-b1w25ob5 1432 2 aureus aureus NN cord-006856-b1w25ob5 1432 3 konnte konnte NNP cord-006856-b1w25ob5 1432 4 in in IN cord-006856-b1w25ob5 1432 5 16 16 CD cord-006856-b1w25ob5 1432 6 Fällen Fällen NNP cord-006856-b1w25ob5 1432 7 ( ( -LRB- cord-006856-b1w25ob5 1432 8 59,3 59,3 CD cord-006856-b1w25ob5 1432 9 % % NN cord-006856-b1w25ob5 1432 10 ) ) -RRB- cord-006856-b1w25ob5 1432 11 und und NNP cord-006856-b1w25ob5 1432 12 Pilze Pilze NNP cord-006856-b1w25ob5 1432 13 konnten konnten NNP cord-006856-b1w25ob5 1432 14 in in IN cord-006856-b1w25ob5 1432 15 4 4 CD cord-006856-b1w25ob5 1432 16 Fällen Fällen NNP cord-006856-b1w25ob5 1432 17 als als NN cord-006856-b1w25ob5 1432 18 ursächliche ursächliche NN cord-006856-b1w25ob5 1432 19 Keime Keime NNP cord-006856-b1w25ob5 1432 20 isoliert isoliert NNP cord-006856-b1w25ob5 1432 21 werden werden NNP cord-006856-b1w25ob5 1432 22 . . . cord-006856-b1w25ob5 1433 1 Die die VB cord-006856-b1w25ob5 1433 2 Inzidenz Inzidenz NNP cord-006856-b1w25ob5 1433 3 der der NNP cord-006856-b1w25ob5 1433 4 Endokarditis Endokarditis NNP cord-006856-b1w25ob5 1433 5 in in IN cord-006856-b1w25ob5 1433 6 Transplantationsempfängern Transplantationsempfängern NNP cord-006856-b1w25ob5 1434 1 beträgt beträgt NNP cord-006856-b1w25ob5 1434 2 1 1 CD cord-006856-b1w25ob5 1434 3 % % NN cord-006856-b1w25ob5 1434 4 ( ( -LRB- cord-006856-b1w25ob5 1434 5 95 95 CD cord-006856-b1w25ob5 1434 6 % % NN cord-006856-b1w25ob5 1434 7 CI CI NNP cord-006856-b1w25ob5 1434 8 , , , cord-006856-b1w25ob5 1434 9 0.67 0.67 CD cord-006856-b1w25ob5 1434 10 - - SYM cord-006856-b1w25ob5 1434 11 1.49 1.49 CD cord-006856-b1w25ob5 1434 12 ) ) -RRB- cord-006856-b1w25ob5 1435 1 und und NNP cord-006856-b1w25ob5 1436 1 zeigt zeigt NNP cord-006856-b1w25ob5 1436 2 ein ein NNP cord-006856-b1w25ob5 1437 1 171-fach 171-fach CD cord-006856-b1w25ob5 1437 2 erhöhtes erhöhtes NNPS cord-006856-b1w25ob5 1438 1 Risiko Risiko NNP cord-006856-b1w25ob5 1438 2 verglichen verglichen NNP cord-006856-b1w25ob5 1438 3 mit mit NNP cord-006856-b1w25ob5 1438 4 der der NNP cord-006856-b1w25ob5 1438 5 Gesamtbevölkerung Gesamtbevölkerung NNP cord-006856-b1w25ob5 1438 6 . . . cord-006856-b1w25ob5 1439 1 Schlussfolgerungen Schlussfolgerungen NNP cord-006856-b1w25ob5 1439 2 . . . cord-006856-b1w25ob5 1440 1 Die die VB cord-006856-b1w25ob5 1440 2 Endokarditis Endokarditis NNP cord-006856-b1w25ob5 1440 3 stellt stellt NNP cord-006856-b1w25ob5 1440 4 ein ein NN cord-006856-b1w25ob5 1440 5 signifikantes signifikante NNS cord-006856-b1w25ob5 1441 1 Problem problem NN cord-006856-b1w25ob5 1441 2 nach nach NNP cord-006856-b1w25ob5 1441 3 Organtransplantation Organtransplantation NNP cord-006856-b1w25ob5 1442 1 dar dar NNP cord-006856-b1w25ob5 1442 2 und und NNP cord-006856-b1w25ob5 1442 3 ist ist NNP cord-006856-b1w25ob5 1442 4 mit mit NNP cord-006856-b1w25ob5 1442 5 einer einer NNP cord-006856-b1w25ob5 1442 6 exzessiv exzessiv NNP cord-006856-b1w25ob5 1442 7 hohen hohen NNP cord-006856-b1w25ob5 1442 8 Mortalität Mortalität NNP cord-006856-b1w25ob5 1442 9 assoziiert assoziiert NN cord-006856-b1w25ob5 1442 10 . . . cord-006856-b1w25ob5 1443 1 Eine Eine NNP cord-006856-b1w25ob5 1443 2 erhöhte erhöhte NNP cord-006856-b1w25ob5 1444 1 Aufmerksamkeit Aufmerksamkeit NNP cord-006856-b1w25ob5 1444 2 ist ist NNP cord-006856-b1w25ob5 1444 3 daher daher NNP cord-006856-b1w25ob5 1444 4 indiziert indiziert NNP cord-006856-b1w25ob5 1444 5 , , , cord-006856-b1w25ob5 1444 6 da da NNP cord-006856-b1w25ob5 1444 7 wir wir NNP cord-006856-b1w25ob5 1445 1 durch durch NNP cord-006856-b1w25ob5 1445 2 den den NNP cord-006856-b1w25ob5 1445 3 Einsatz Einsatz NNP cord-006856-b1w25ob5 1445 4 der der NN cord-006856-b1w25ob5 1445 5 transösophagealen transösophagealen VBN cord-006856-b1w25ob5 1445 6 Echokardiographie Echokardiographie NNP cord-006856-b1w25ob5 1445 7 vermehrt vermehrt NN cord-006856-b1w25ob5 1445 8 derartige derartige NNS cord-006856-b1w25ob5 1445 9 Fälle Fälle NNP cord-006856-b1w25ob5 1445 10 in in IN cord-006856-b1w25ob5 1445 11 der der NNP cord-006856-b1w25ob5 1445 12 Zukunft Zukunft NNP cord-006856-b1w25ob5 1445 13 diagnostizieren diagnostizieren NNP cord-006856-b1w25ob5 1446 1 werden werden NNP cord-006856-b1w25ob5 1446 2 . . . cord-006856-b1w25ob5 1447 1 Ein Ein NNP cord-006856-b1w25ob5 1447 2 47-jähriger 47-jähriger CD cord-006856-b1w25ob5 1447 3 Patient Patient NNP cord-006856-b1w25ob5 1447 4 erhält erhält NNP cord-006856-b1w25ob5 1447 5 1995 1995 CD cord-006856-b1w25ob5 1447 6 eine eine NNP cord-006856-b1w25ob5 1448 1 Herztransplantation Herztransplantation NNP cord-006856-b1w25ob5 1448 2 aufgrund aufgrund IN cord-006856-b1w25ob5 1448 3 einer einer NNP cord-006856-b1w25ob5 1448 4 dilatativen dilatativen NNP cord-006856-b1w25ob5 1449 1 Kardiomyopathie Kardiomyopathie NNP cord-006856-b1w25ob5 1449 2 bei bei NNP cord-006856-b1w25ob5 1449 3 altersentsprechender altersentsprechender NN cord-006856-b1w25ob5 1449 4 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 1449 5 . . . cord-006856-b1w25ob5 1450 1 Die die VB cord-006856-b1w25ob5 1450 2 Immunsuppression Immunsuppression NNP cord-006856-b1w25ob5 1450 3 besteht besteht NNP cord-006856-b1w25ob5 1450 4 aus aus NN cord-006856-b1w25ob5 1451 1 Cyclosporin cyclosporin VB cord-006856-b1w25ob5 1451 2 A a DT cord-006856-b1w25ob5 1451 3 und und IN cord-006856-b1w25ob5 1451 4 Mycophenolat Mycophenolat NNP cord-006856-b1w25ob5 1451 5 Mofetil Mofetil NNP cord-006856-b1w25ob5 1451 6 . . . cord-006856-b1w25ob5 1452 1 Innerhalb Innerhalb NNP cord-006856-b1w25ob5 1452 2 der der NN cord-006856-b1w25ob5 1452 3 ersten ersten NNP cord-006856-b1w25ob5 1452 4 drei drei NNP cord-006856-b1w25ob5 1452 5 Monate Monate NNP cord-006856-b1w25ob5 1452 6 nach nach NNP cord-006856-b1w25ob5 1452 7 der der NNP cord-006856-b1w25ob5 1452 8 Operation Operation NNP cord-006856-b1w25ob5 1452 9 steigt steigt NNP cord-006856-b1w25ob5 1452 10 das das NNP cord-006856-b1w25ob5 1452 11 Kreatinin Kreatinin NNP cord-006856-b1w25ob5 1452 12 auf auf NNP cord-006856-b1w25ob5 1452 13 2,0 2,0 CD cord-006856-b1w25ob5 1452 14 mg mg NNP cord-006856-b1w25ob5 1452 15 / / SYM cord-006856-b1w25ob5 1452 16 dl dl NNP cord-006856-b1w25ob5 1452 17 an an NNP cord-006856-b1w25ob5 1452 18 , , , cord-006856-b1w25ob5 1452 19 bleibt bleibt NNP cord-006856-b1w25ob5 1452 20 dann dann NNP cord-006856-b1w25ob5 1452 21 aber aber NNP cord-006856-b1w25ob5 1452 22 konstant konstant NNP cord-006856-b1w25ob5 1452 23 . . . cord-006856-b1w25ob5 1453 1 Ab Ab NNP cord-006856-b1w25ob5 1453 2 2003 2003 CD cord-006856-b1w25ob5 1453 3 nimmt nimmt NNP cord-006856-b1w25ob5 1453 4 die die VB cord-006856-b1w25ob5 1454 1 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 1454 2 weiter weiter NNP cord-006856-b1w25ob5 1454 3 ab ab NNP cord-006856-b1w25ob5 1454 4 , , , cord-006856-b1w25ob5 1454 5 weshalb weshalb NNP cord-006856-b1w25ob5 1455 1 i -PRON- PRP cord-006856-b1w25ob5 1455 2 m be VBP cord-006856-b1w25ob5 1455 3 August August NNP cord-006856-b1w25ob5 1455 4 2004 2004 CD cord-006856-b1w25ob5 1456 1 wegen wegen NNP cord-006856-b1w25ob5 1456 2 des des NNP cord-006856-b1w25ob5 1456 3 Verdachtes Verdachtes NNP cord-006856-b1w25ob5 1456 4 auf auf NNP cord-006856-b1w25ob5 1456 5 eine eine NNP cord-006856-b1w25ob5 1456 6 chronische chronische NNP cord-006856-b1w25ob5 1457 1 Calcineurininhibitor Calcineurininhibitor NNP cord-006856-b1w25ob5 1457 2 - - HYPH cord-006856-b1w25ob5 1457 3 Nephropathie Nephropathie NNP cord-006856-b1w25ob5 1457 4 auf auf NNP cord-006856-b1w25ob5 1457 5 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1457 6 und und IN cord-006856-b1w25ob5 1457 7 MMF MMF NNP cord-006856-b1w25ob5 1457 8 umgestellt umgestellt NNP cord-006856-b1w25ob5 1457 9 wird wird NNP cord-006856-b1w25ob5 1457 10 . . . cord-006856-b1w25ob5 1458 1 Das Das NNP cord-006856-b1w25ob5 1458 2 Serum Serum NNP cord-006856-b1w25ob5 1458 3 - - HYPH cord-006856-b1w25ob5 1458 4 Kreatinin Kreatinin NNP cord-006856-b1w25ob5 1458 5 beträgt beträgt NN cord-006856-b1w25ob5 1458 6 zu zu XX cord-006856-b1w25ob5 1458 7 diesem diesem NNP cord-006856-b1w25ob5 1458 8 Zeitpunkt Zeitpunkt NNP cord-006856-b1w25ob5 1458 9 3,0 3,0 CD cord-006856-b1w25ob5 1459 1 mg mg NNP cord-006856-b1w25ob5 1459 2 / / SYM cord-006856-b1w25ob5 1459 3 dl dl NNP cord-006856-b1w25ob5 1459 4 . . . cord-006856-b1w25ob5 1460 1 Zwei Zwei NNP cord-006856-b1w25ob5 1460 2 Monate Monate NNP cord-006856-b1w25ob5 1460 3 später später NNP cord-006856-b1w25ob5 1460 4 ist ist NNP cord-006856-b1w25ob5 1460 5 das das NNP cord-006856-b1w25ob5 1460 6 Serum Serum NNP cord-006856-b1w25ob5 1460 7 - - HYPH cord-006856-b1w25ob5 1460 8 Kreatinin Kreatinin NNP cord-006856-b1w25ob5 1460 9 auf auf NNP cord-006856-b1w25ob5 1460 10 7,0 7,0 CD cord-006856-b1w25ob5 1460 11 angestiegen angestiegen NNP cord-006856-b1w25ob5 1460 12 , , , cord-006856-b1w25ob5 1460 13 der der NNP cord-006856-b1w25ob5 1460 14 inzwischen inzwischen NNP cord-006856-b1w25ob5 1460 15 57-jährige 57-jährige CD cord-006856-b1w25ob5 1460 16 Patient Patient NNP cord-006856-b1w25ob5 1460 17 leidet leidet NNP cord-006856-b1w25ob5 1460 18 unter unter NNP cord-006856-b1w25ob5 1460 19 einer einer NNP cord-006856-b1w25ob5 1461 1 renalen renalen NNP cord-006856-b1w25ob5 1461 2 Anämie Anämie NNP cord-006856-b1w25ob5 1461 3 , , , cord-006856-b1w25ob5 1461 4 Hyperphosphatämie Hyperphosphatämie NNP cord-006856-b1w25ob5 1461 5 und und IN cord-006856-b1w25ob5 1461 6 Hypokalziämie Hypokalziämie NNP cord-006856-b1w25ob5 1461 7 . . . cord-006856-b1w25ob5 1462 1 I -PRON- PRP cord-006856-b1w25ob5 1462 2 m be VBP cord-006856-b1w25ob5 1462 3 Harn Harn NNP cord-006856-b1w25ob5 1462 4 finden finden NNP cord-006856-b1w25ob5 1462 5 sich sich NNP cord-006856-b1w25ob5 1462 6 Leukozyten Leukozyten NNP cord-006856-b1w25ob5 1462 7 und und IN cord-006856-b1w25ob5 1462 8 Erythrozyten Erythrozyten NNP cord-006856-b1w25ob5 1462 9 , , , cord-006856-b1w25ob5 1462 10 die die VB cord-006856-b1w25ob5 1462 11 allerdings allerdings NNP cord-006856-b1w25ob5 1462 12 nicht nicht NNP cord-006856-b1w25ob5 1462 13 deformiert deformiert NNP cord-006856-b1w25ob5 1462 14 sind sind NNP cord-006856-b1w25ob5 1462 15 ( ( -LRB- cord-006856-b1w25ob5 1462 16 keine keine FW cord-006856-b1w25ob5 1462 17 dysmorphen dysmorphen NNP cord-006856-b1w25ob5 1462 18 Erythrozyten Erythrozyten NNP cord-006856-b1w25ob5 1462 19 und und IN cord-006856-b1w25ob5 1462 20 Akanthozyten Akanthozyten NNP cord-006856-b1w25ob5 1462 21 ) ) -RRB- cord-006856-b1w25ob5 1462 22 , , , cord-006856-b1w25ob5 1462 23 sowie sowie NNP cord-006856-b1w25ob5 1462 24 eine eine NNP cord-006856-b1w25ob5 1462 25 geringgradige geringgradige NNP cord-006856-b1w25ob5 1462 26 Proteinurie Proteinurie NNP cord-006856-b1w25ob5 1462 27 ( ( -LRB- cord-006856-b1w25ob5 1462 28 300 300 CD cord-006856-b1w25ob5 1462 29 mg/24 mg/24 NN cord-006856-b1w25ob5 1462 30 h h NN cord-006856-b1w25ob5 1462 31 ) ) -RRB- cord-006856-b1w25ob5 1462 32 . . . cord-006856-b1w25ob5 1463 1 In in IN cord-006856-b1w25ob5 1463 2 der der NNP cord-006856-b1w25ob5 1463 3 Harn Harn NNP cord-006856-b1w25ob5 1463 4 - - HYPH cord-006856-b1w25ob5 1463 5 Polyacrylamidgel Polyacrylamidgel NNP cord-006856-b1w25ob5 1463 6 - - HYPH cord-006856-b1w25ob5 1463 7 Elektrophorese Elektrophorese NNP cord-006856-b1w25ob5 1463 8 zeigt zeigt NNP cord-006856-b1w25ob5 1463 9 sich sich NNP cord-006856-b1w25ob5 1463 10 vor vor NNP cord-006856-b1w25ob5 1464 1 allem allem NNP cord-006856-b1w25ob5 1464 2 Alpha-1-Mikroglobulin Alpha-1-Mikroglobulin NNP cord-006856-b1w25ob5 1464 3 als als NNP cord-006856-b1w25ob5 1465 1 Indikator Indikator NNP cord-006856-b1w25ob5 1465 2 einer einer NNP cord-006856-b1w25ob5 1465 3 tubulointerstitiellen tubulointerstitiellen NNP cord-006856-b1w25ob5 1465 4 Schädigung Schädigung NNP cord-006856-b1w25ob5 1465 5 . . . cord-006856-b1w25ob5 1466 1 Nach Nach NNP cord-006856-b1w25ob5 1466 2 erneuter erneuter NNP cord-006856-b1w25ob5 1467 1 Umstellung Umstellung NNP cord-006856-b1w25ob5 1467 2 der der NNP cord-006856-b1w25ob5 1468 1 Immunsuppression Immunsuppression NNP cord-006856-b1w25ob5 1468 2 von von NNP cord-006856-b1w25ob5 1468 3 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1468 4 / / SYM cord-006856-b1w25ob5 1468 5 MMF MMF NNP cord-006856-b1w25ob5 1468 6 auf auf NNP cord-006856-b1w25ob5 1468 7 Niedrigdosis Niedrigdosis NNP cord-006856-b1w25ob5 1468 8 - - HYPH cord-006856-b1w25ob5 1468 9 Cyclosporin Cyclosporin NNP cord-006856-b1w25ob5 1468 10 / / SYM cord-006856-b1w25ob5 1468 11 MMF MMF NNP cord-006856-b1w25ob5 1468 12 kommt kommt NNP cord-006856-b1w25ob5 1468 13 es es NNP cord-006856-b1w25ob5 1468 14 zum zum NNP cord-006856-b1w25ob5 1468 15 raschen raschen NNP cord-006856-b1w25ob5 1469 1 Rückgang Rückgang NNP cord-006856-b1w25ob5 1469 2 des des NNP cord-006856-b1w25ob5 1469 3 Serum Serum NNP cord-006856-b1w25ob5 1469 4 - - HYPH cord-006856-b1w25ob5 1469 5 Kreatinins Kreatinins NNP cord-006856-b1w25ob5 1469 6 , , , cord-006856-b1w25ob5 1470 1 der der NNP cord-006856-b1w25ob5 1470 2 Harnbefund Harnbefund NNP cord-006856-b1w25ob5 1470 3 sowie sowie NNP cord-006856-b1w25ob5 1470 4 die die VBP cord-006856-b1w25ob5 1471 1 Elektrolyte Elektrolyte NNP cord-006856-b1w25ob5 1471 2 normalisieren normalisieren NNP cord-006856-b1w25ob5 1471 3 sich sich NNP cord-006856-b1w25ob5 1471 4 , , , cord-006856-b1w25ob5 1471 5 einzig einzig NNP cord-006856-b1w25ob5 1471 6 die die VBP cord-006856-b1w25ob5 1472 1 Erythropoetin Erythropoetin NNP cord-006856-b1w25ob5 1472 2 - - HYPH cord-006856-b1w25ob5 1472 3 Substitution substitution NN cord-006856-b1w25ob5 1472 4 muss muss VBP cord-006856-b1w25ob5 1472 5 beibehalten beibehalten NNP cord-006856-b1w25ob5 1472 6 werden werden NNP cord-006856-b1w25ob5 1472 7 , , , cord-006856-b1w25ob5 1472 8 um um UH cord-006856-b1w25ob5 1472 9 den den NNP cord-006856-b1w25ob5 1472 10 Hämoglobin Hämoglobin NNP cord-006856-b1w25ob5 1472 11 - - HYPH cord-006856-b1w25ob5 1472 12 Zielwert Zielwert NNP cord-006856-b1w25ob5 1472 13 von von NNP cord-006856-b1w25ob5 1472 14 11 11 CD cord-006856-b1w25ob5 1473 1 g g NNP cord-006856-b1w25ob5 1473 2 / / SYM cord-006856-b1w25ob5 1473 3 dl dl NNP cord-006856-b1w25ob5 1473 4 zu zu NNP cord-006856-b1w25ob5 1473 5 erreichen erreichen NNP cord-006856-b1w25ob5 1473 6 . . . cord-006856-b1w25ob5 1474 1 Acht Acht NNP cord-006856-b1w25ob5 1474 2 Wochen Wochen NNP cord-006856-b1w25ob5 1474 3 nach nach NNP cord-006856-b1w25ob5 1474 4 der der NNP cord-006856-b1w25ob5 1474 5 zweiten zweiten NNP cord-006856-b1w25ob5 1474 6 Therapieumstellung Therapieumstellung NNP cord-006856-b1w25ob5 1474 7 führen führen NNP cord-006856-b1w25ob5 1474 8 wir wir NNP cord-006856-b1w25ob5 1474 9 eine eine NNP cord-006856-b1w25ob5 1474 10 Nierenbiopsie Nierenbiopsie NNP cord-006856-b1w25ob5 1474 11 durch durch NNP cord-006856-b1w25ob5 1474 12 . . . cord-006856-b1w25ob5 1475 1 Es Es NNP cord-006856-b1w25ob5 1475 2 findet findet NNP cord-006856-b1w25ob5 1475 3 sich sich NNP cord-006856-b1w25ob5 1475 4 eine eine NNP cord-006856-b1w25ob5 1475 5 akute akute NNP cord-006856-b1w25ob5 1475 6 interstitielle interstitielle NNP cord-006856-b1w25ob5 1476 1 Nephritis nephritis NN cord-006856-b1w25ob5 1476 2 ohne ohne NNP cord-006856-b1w25ob5 1476 3 glomeruläre glomeruläre NNP cord-006856-b1w25ob5 1476 4 Schädigung Schädigung NNP cord-006856-b1w25ob5 1476 5 . . . cord-006856-b1w25ob5 1477 1 Unseres Unseres NNP cord-006856-b1w25ob5 1477 2 Wissens Wissens NNP cord-006856-b1w25ob5 1477 3 ist ist NN cord-006856-b1w25ob5 1477 4 dies die VBZ cord-006856-b1w25ob5 1477 5 der der NN cord-006856-b1w25ob5 1477 6 erste erste NNP cord-006856-b1w25ob5 1477 7 dokumentierte dokumentierte NNP cord-006856-b1w25ob5 1477 8 Fall Fall NNP cord-006856-b1w25ob5 1477 9 einer einer NNP cord-006856-b1w25ob5 1477 10 akuten akuten NNP cord-006856-b1w25ob5 1477 11 interstitiellen interstitiellen NNP cord-006856-b1w25ob5 1477 12 Nephritis Nephritis NNP cord-006856-b1w25ob5 1477 13 auf auf NNP cord-006856-b1w25ob5 1477 14 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1477 15 . . . cord-006856-b1w25ob5 1478 1 Background background NN cord-006856-b1w25ob5 1478 2 . . . cord-006856-b1w25ob5 1479 1 Group Group NNP cord-006856-b1w25ob5 1479 2 Milleri Milleri NNP cord-006856-b1w25ob5 1479 3 streptococci streptococcus NNS cord-006856-b1w25ob5 1479 4 ( ( -LRB- cord-006856-b1w25ob5 1479 5 GMS GMS NNP cord-006856-b1w25ob5 1479 6 ) ) -RRB- cord-006856-b1w25ob5 1479 7 are be VBP cord-006856-b1w25ob5 1479 8 a a DT cord-006856-b1w25ob5 1479 9 heterogeneous heterogeneous JJ cord-006856-b1w25ob5 1479 10 group group NN cord-006856-b1w25ob5 1479 11 of of IN cord-006856-b1w25ob5 1479 12 streptococci streptococcus NNS cord-006856-b1w25ob5 1479 13 including include VBG cord-006856-b1w25ob5 1479 14 the the DT cord-006856-b1w25ob5 1479 15 species specie NNS cord-006856-b1w25ob5 1479 16 Streptococcus Streptococcus NNP cord-006856-b1w25ob5 1479 17 intermedius intermedius NN cord-006856-b1w25ob5 1479 18 , , , cord-006856-b1w25ob5 1479 19 S. S. NNP cord-006856-b1w25ob5 1479 20 constellatus constellatus NN cord-006856-b1w25ob5 1479 21 , , , cord-006856-b1w25ob5 1479 22 and and CC cord-006856-b1w25ob5 1479 23 S. S. NNP cord-006856-b1w25ob5 1479 24 anginosus anginosu NNS cord-006856-b1w25ob5 1479 25 . . . cord-006856-b1w25ob5 1480 1 Due due IN cord-006856-b1w25ob5 1480 2 to to IN cord-006856-b1w25ob5 1480 3 their -PRON- PRP$ cord-006856-b1w25ob5 1480 4 ability ability NN cord-006856-b1w25ob5 1480 5 of of IN cord-006856-b1w25ob5 1480 6 producing produce VBG cord-006856-b1w25ob5 1480 7 toxins toxin NNS cord-006856-b1w25ob5 1480 8 , , , cord-006856-b1w25ob5 1480 9 they -PRON- PRP cord-006856-b1w25ob5 1480 10 tend tend VBP cord-006856-b1w25ob5 1480 11 to to TO cord-006856-b1w25ob5 1480 12 cause cause VB cord-006856-b1w25ob5 1480 13 chronic chronic JJ cord-006856-b1w25ob5 1480 14 intra intra JJ cord-006856-b1w25ob5 1480 15 - - JJ cord-006856-b1w25ob5 1480 16 abdominal abdominal JJ cord-006856-b1w25ob5 1480 17 and and CC cord-006856-b1w25ob5 1480 18 intrathoracic intrathoracic JJ cord-006856-b1w25ob5 1480 19 abscesses abscess NNS cord-006856-b1w25ob5 1480 20 , , , cord-006856-b1w25ob5 1480 21 which which WDT cord-006856-b1w25ob5 1480 22 are be VBP cord-006856-b1w25ob5 1480 23 difficult difficult JJ cord-006856-b1w25ob5 1480 24 to to TO cord-006856-b1w25ob5 1480 25 treat treat VB cord-006856-b1w25ob5 1480 26 , , , cord-006856-b1w25ob5 1480 27 as as IN cord-006856-b1w25ob5 1480 28 GMS GMS NNP cord-006856-b1w25ob5 1480 29 are be VBP cord-006856-b1w25ob5 1480 30 able able JJ cord-006856-b1w25ob5 1480 31 to to TO cord-006856-b1w25ob5 1480 32 escape escape VB cord-006856-b1w25ob5 1480 33 conventional conventional JJ cord-006856-b1w25ob5 1480 34 antibiotic antibiotic JJ cord-006856-b1w25ob5 1480 35 therapy therapy NN cord-006856-b1w25ob5 1480 36 . . . cord-006856-b1w25ob5 1481 1 Aim aim VB cord-006856-b1w25ob5 1481 2 . . . cord-006856-b1w25ob5 1482 1 Evaluation evaluation NN cord-006856-b1w25ob5 1482 2 of of IN cord-006856-b1w25ob5 1482 3 epidemiology epidemiology NN cord-006856-b1w25ob5 1482 4 , , , cord-006856-b1w25ob5 1482 5 clinical clinical JJ cord-006856-b1w25ob5 1482 6 significance significance NN cord-006856-b1w25ob5 1482 7 , , , cord-006856-b1w25ob5 1482 8 and and CC cord-006856-b1w25ob5 1482 9 impact impact NN cord-006856-b1w25ob5 1482 10 on on IN cord-006856-b1w25ob5 1482 11 the the DT cord-006856-b1w25ob5 1482 12 outcome outcome NN cord-006856-b1w25ob5 1482 13 in in IN cord-006856-b1w25ob5 1482 14 all all DT cord-006856-b1w25ob5 1482 15 solid solid JJ cord-006856-b1w25ob5 1482 16 - - HYPH cord-006856-b1w25ob5 1482 17 organ organ NN cord-006856-b1w25ob5 1482 18 recipients recipient NNS cord-006856-b1w25ob5 1482 19 with with IN cord-006856-b1w25ob5 1482 20 GSM GSM NNP cord-006856-b1w25ob5 1482 21 infections infection NNS cord-006856-b1w25ob5 1482 22 during during IN cord-006856-b1w25ob5 1482 23 a a DT cord-006856-b1w25ob5 1482 24 4-year 4-year CD cord-006856-b1w25ob5 1482 25 period period NN cord-006856-b1w25ob5 1482 26 . . . cord-006856-b1w25ob5 1483 1 Patients patient NNS cord-006856-b1w25ob5 1483 2 and and CC cord-006856-b1w25ob5 1483 3 Methods method NNS cord-006856-b1w25ob5 1483 4 . . . cord-006856-b1w25ob5 1484 1 Retrospective retrospective JJ cord-006856-b1w25ob5 1484 2 analysis analysis NN cord-006856-b1w25ob5 1484 3 comprising comprise VBG cord-006856-b1w25ob5 1484 4 45 45 CD cord-006856-b1w25ob5 1484 5 solid solid JJ cord-006856-b1w25ob5 1484 6 - - HYPH cord-006856-b1w25ob5 1484 7 organ organ NN cord-006856-b1w25ob5 1484 8 recipients recipient NNS cord-006856-b1w25ob5 1484 9 with with IN cord-006856-b1w25ob5 1484 10 GMS GMS NNP cord-006856-b1w25ob5 1484 11 . . . cord-006856-b1w25ob5 1485 1 Results result NNS cord-006856-b1w25ob5 1485 2 . . . cord-006856-b1w25ob5 1486 1 Between between IN cord-006856-b1w25ob5 1486 2 2001 2001 CD cord-006856-b1w25ob5 1486 3 and and CC cord-006856-b1w25ob5 1486 4 2004 2004 CD cord-006856-b1w25ob5 1486 5 , , , cord-006856-b1w25ob5 1486 6 45 45 CD cord-006856-b1w25ob5 1486 7 solid solid JJ cord-006856-b1w25ob5 1486 8 organ organ NN cord-006856-b1w25ob5 1486 9 recipients recipient NNS cord-006856-b1w25ob5 1486 10 ( ( -LRB- cord-006856-b1w25ob5 1486 11 88 88 CD cord-006856-b1w25ob5 1486 12 isolates isolate NNS cord-006856-b1w25ob5 1486 13 ) ) -RRB- cord-006856-b1w25ob5 1486 14 including include VBG cord-006856-b1w25ob5 1486 15 34 34 CD cord-006856-b1w25ob5 1486 16 liver liver NN cord-006856-b1w25ob5 1486 17 , , , cord-006856-b1w25ob5 1486 18 four four CD cord-006856-b1w25ob5 1486 19 kidney kidney NN cord-006856-b1w25ob5 1486 20 and and CC cord-006856-b1w25ob5 1486 21 pancreas pancreas NN cord-006856-b1w25ob5 1486 22 , , , cord-006856-b1w25ob5 1486 23 one one CD cord-006856-b1w25ob5 1486 24 kidney kidney NN cord-006856-b1w25ob5 1486 25 , , , cord-006856-b1w25ob5 1486 26 two two CD cord-006856-b1w25ob5 1486 27 small small JJ cord-006856-b1w25ob5 1486 28 bowel bowel NN cord-006856-b1w25ob5 1486 29 , , , cord-006856-b1w25ob5 1486 30 three three CD cord-006856-b1w25ob5 1486 31 combined combine VBN cord-006856-b1w25ob5 1486 32 liver liver NN cord-006856-b1w25ob5 1486 33 and and CC cord-006856-b1w25ob5 1486 34 kidney kidney NN cord-006856-b1w25ob5 1486 35 , , , cord-006856-b1w25ob5 1486 36 and and CC cord-006856-b1w25ob5 1486 37 one one CD cord-006856-b1w25ob5 1486 38 combined combine VBN cord-006856-b1w25ob5 1486 39 kidney kidney NN cord-006856-b1w25ob5 1486 40 and and CC cord-006856-b1w25ob5 1486 41 small small JJ cord-006856-b1w25ob5 1486 42 bowel bowel NN cord-006856-b1w25ob5 1486 43 transplant transplant NN cord-006856-b1w25ob5 1486 44 re re NNS cord-006856-b1w25ob5 1486 45 - - NN cord-006856-b1w25ob5 1486 46 cipients cipient NNS cord-006856-b1w25ob5 1486 47 developed develop VBD cord-006856-b1w25ob5 1486 48 infection infection NN cord-006856-b1w25ob5 1486 49 with with IN cord-006856-b1w25ob5 1486 50 GMS GMS NNP cord-006856-b1w25ob5 1486 51 . . . cord-006856-b1w25ob5 1487 1 In in IN cord-006856-b1w25ob5 1487 2 42 42 CD cord-006856-b1w25ob5 1487 3 cases case NNS cord-006856-b1w25ob5 1487 4 , , , cord-006856-b1w25ob5 1487 5 GMS GMS NNP cord-006856-b1w25ob5 1487 6 caused cause VBD cord-006856-b1w25ob5 1487 7 intra intra JJ cord-006856-b1w25ob5 1487 8 - - JJ cord-006856-b1w25ob5 1487 9 abdominal abdominal JJ cord-006856-b1w25ob5 1487 10 infection infection NN cord-006856-b1w25ob5 1487 11 ; ; : cord-006856-b1w25ob5 1487 12 in in IN cord-006856-b1w25ob5 1487 13 two two CD cord-006856-b1w25ob5 1487 14 cases case NNS cord-006856-b1w25ob5 1487 15 , , , cord-006856-b1w25ob5 1487 16 pleural pleural JJ cord-006856-b1w25ob5 1487 17 empyema empyema NN cord-006856-b1w25ob5 1487 18 ; ; : cord-006856-b1w25ob5 1487 19 and and CC cord-006856-b1w25ob5 1487 20 in in IN cord-006856-b1w25ob5 1487 21 one one CD cord-006856-b1w25ob5 1487 22 case case NN cord-006856-b1w25ob5 1487 23 , , , cord-006856-b1w25ob5 1487 24 soft soft JJ cord-006856-b1w25ob5 1487 25 tissue tissue NN cord-006856-b1w25ob5 1487 26 infection infection NN cord-006856-b1w25ob5 1487 27 . . . cord-006856-b1w25ob5 1488 1 In in IN cord-006856-b1w25ob5 1488 2 only only RB cord-006856-b1w25ob5 1488 3 one one CD cord-006856-b1w25ob5 1488 4 case case NN cord-006856-b1w25ob5 1488 5 , , , cord-006856-b1w25ob5 1488 6 GMS GMS NNP cord-006856-b1w25ob5 1488 7 were be VBD cord-006856-b1w25ob5 1488 8 cultured culture VBN cord-006856-b1w25ob5 1488 9 from from IN cord-006856-b1w25ob5 1488 10 blood blood NN cord-006856-b1w25ob5 1488 11 . . . cord-006856-b1w25ob5 1489 1 In in IN cord-006856-b1w25ob5 1489 2 54 54 CD cord-006856-b1w25ob5 1489 3 of of IN cord-006856-b1w25ob5 1489 4 the the DT cord-006856-b1w25ob5 1489 5 88 88 CD cord-006856-b1w25ob5 1489 6 specimens specimen NNS cord-006856-b1w25ob5 1489 7 ( ( -LRB- cord-006856-b1w25ob5 1489 8 61 61 CD cord-006856-b1w25ob5 1489 9 % % NN cord-006856-b1w25ob5 1489 10 ) ) -RRB- cord-006856-b1w25ob5 1489 11 which which WDT cord-006856-b1w25ob5 1489 12 grew grow VBD cord-006856-b1w25ob5 1489 13 GMS GMS NNP cord-006856-b1w25ob5 1489 14 , , , cord-006856-b1w25ob5 1489 15 also also RB cord-006856-b1w25ob5 1489 16 other other JJ cord-006856-b1w25ob5 1489 17 pathogens pathogen NNS cord-006856-b1w25ob5 1489 18 could could MD cord-006856-b1w25ob5 1489 19 be be VB cord-006856-b1w25ob5 1489 20 isolated isolate VBN cord-006856-b1w25ob5 1489 21 . . . cord-006856-b1w25ob5 1490 1 GMS GMS NNP cord-006856-b1w25ob5 1490 2 frequently frequently RB cord-006856-b1w25ob5 1490 3 caused cause VBD cord-006856-b1w25ob5 1490 4 recurrent recurrent JJ cord-006856-b1w25ob5 1490 5 cholangitis cholangitis NN cord-006856-b1w25ob5 1490 6 ( ( -LRB- cord-006856-b1w25ob5 1490 7 n n NN cord-006856-b1w25ob5 1490 8 = = SYM cord-006856-b1w25ob5 1490 9 17 17 CD cord-006856-b1w25ob5 1490 10 ) ) -RRB- cord-006856-b1w25ob5 1490 11 associated associate VBN cord-006856-b1w25ob5 1490 12 with with IN cord-006856-b1w25ob5 1490 13 anastomotic anastomotic JJ cord-006856-b1w25ob5 1490 14 and and CC cord-006856-b1w25ob5 1490 15 anastomotic anastomotic JJ cord-006856-b1w25ob5 1490 16 biliary biliary JJ cord-006856-b1w25ob5 1490 17 strictures stricture NNS cord-006856-b1w25ob5 1490 18 . . . cord-006856-b1w25ob5 1491 1 These these DT cord-006856-b1w25ob5 1491 2 cases case NNS cord-006856-b1w25ob5 1491 3 were be VBD cord-006856-b1w25ob5 1491 4 managed manage VBN cord-006856-b1w25ob5 1491 5 by by IN cord-006856-b1w25ob5 1491 6 repeated repeat VBN cord-006856-b1w25ob5 1491 7 stenting stenting NN cord-006856-b1w25ob5 1491 8 or or CC cord-006856-b1w25ob5 1491 9 surgical surgical JJ cord-006856-b1w25ob5 1491 10 intervention intervention NN cord-006856-b1w25ob5 1491 11 and and CC cord-006856-b1w25ob5 1491 12 prolonged prolong VBD cord-006856-b1w25ob5 1491 13 antibiotic antibiotic JJ cord-006856-b1w25ob5 1491 14 therapy therapy NN cord-006856-b1w25ob5 1491 15 . . . cord-006856-b1w25ob5 1492 1 No no DT cord-006856-b1w25ob5 1492 2 patient patient NN cord-006856-b1w25ob5 1492 3 died die VBD cord-006856-b1w25ob5 1492 4 directly directly RB cord-006856-b1w25ob5 1492 5 related relate VBN cord-006856-b1w25ob5 1492 6 to to IN cord-006856-b1w25ob5 1492 7 GMS GMS NNP cord-006856-b1w25ob5 1492 8 infection infection NN cord-006856-b1w25ob5 1492 9 . . . cord-006856-b1w25ob5 1493 1 All all DT cord-006856-b1w25ob5 1493 2 responded respond VBD cord-006856-b1w25ob5 1493 3 to to IN cord-006856-b1w25ob5 1493 4 combined combine VBN cord-006856-b1w25ob5 1493 5 surgical surgical JJ cord-006856-b1w25ob5 1493 6 and and CC cord-006856-b1w25ob5 1493 7 antibiotic antibiotic JJ cord-006856-b1w25ob5 1493 8 treatment treatment NN cord-006856-b1w25ob5 1493 9 . . . cord-006856-b1w25ob5 1494 1 One one CD cord-006856-b1w25ob5 1494 2 pancreas pancreas NN cord-006856-b1w25ob5 1494 3 graft graft NN cord-006856-b1w25ob5 1494 4 was be VBD cord-006856-b1w25ob5 1494 5 lost lose VBN cord-006856-b1w25ob5 1494 6 due due IN cord-006856-b1w25ob5 1494 7 to to IN cord-006856-b1w25ob5 1494 8 erosion erosion NN cord-006856-b1w25ob5 1494 9 haemorrhage haemorrhage NN cord-006856-b1w25ob5 1494 10 associated associate VBN cord-006856-b1w25ob5 1494 11 with with IN cord-006856-b1w25ob5 1494 12 an an DT cord-006856-b1w25ob5 1494 13 abscess abscess NN cord-006856-b1w25ob5 1494 14 . . . cord-006856-b1w25ob5 1495 1 All all DT cord-006856-b1w25ob5 1495 2 isolated isolate VBN cord-006856-b1w25ob5 1495 3 strains strain NNS cord-006856-b1w25ob5 1495 4 of of IN cord-006856-b1w25ob5 1495 5 GMS GMS NNP cord-006856-b1w25ob5 1495 6 were be VBD cord-006856-b1w25ob5 1495 7 susceptible susceptible JJ cord-006856-b1w25ob5 1495 8 to to IN cord-006856-b1w25ob5 1495 9 Penicillin Penicillin NNP cord-006856-b1w25ob5 1495 10 G G NNP cord-006856-b1w25ob5 1495 11 , , , cord-006856-b1w25ob5 1495 12 Carbapenems Carbapenems NNP cord-006856-b1w25ob5 1495 13 , , , cord-006856-b1w25ob5 1495 14 and and CC cord-006856-b1w25ob5 1495 15 Clindamycin Clindamycin NNP cord-006856-b1w25ob5 1495 16 , , , cord-006856-b1w25ob5 1495 17 whereas whereas IN cord-006856-b1w25ob5 1495 18 cephalosporins cephalosporin NNS cord-006856-b1w25ob5 1495 19 and and CC cord-006856-b1w25ob5 1495 20 quinolones quinolone NNS cord-006856-b1w25ob5 1495 21 showed show VBD cord-006856-b1w25ob5 1495 22 intermediate intermediate JJ cord-006856-b1w25ob5 1495 23 activity activity NN cord-006856-b1w25ob5 1495 24 or or CC cord-006856-b1w25ob5 1495 25 resistance resistance NN cord-006856-b1w25ob5 1495 26 in in IN cord-006856-b1w25ob5 1495 27 some some DT cord-006856-b1w25ob5 1495 28 cases case NNS cord-006856-b1w25ob5 1495 29 and and CC cord-006856-b1w25ob5 1495 30 GMS GMS NNP cord-006856-b1w25ob5 1495 31 in in IN cord-006856-b1w25ob5 1495 32 general general JJ cord-006856-b1w25ob5 1495 33 were be VBD cord-006856-b1w25ob5 1495 34 found find VBN cord-006856-b1w25ob5 1495 35 resistant resistant JJ cord-006856-b1w25ob5 1495 36 to to IN cord-006856-b1w25ob5 1495 37 aminoglycosides aminoglycoside NNS cord-006856-b1w25ob5 1495 38 . . . cord-006856-b1w25ob5 1496 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1496 2 . . . cord-006856-b1w25ob5 1497 1 GMS GMS NNP cord-006856-b1w25ob5 1497 2 are be VBP cord-006856-b1w25ob5 1497 3 frequent frequent JJ cord-006856-b1w25ob5 1497 4 pathogens pathogen NNS cord-006856-b1w25ob5 1497 5 in in IN cord-006856-b1w25ob5 1497 6 transplant transplant NN cord-006856-b1w25ob5 1497 7 surgery surgery NN cord-006856-b1w25ob5 1497 8 and and CC cord-006856-b1w25ob5 1497 9 are be VBP cord-006856-b1w25ob5 1497 10 capable capable JJ cord-006856-b1w25ob5 1497 11 of of IN cord-006856-b1w25ob5 1497 12 causing cause VBG cord-006856-b1w25ob5 1497 13 difficult difficult JJ cord-006856-b1w25ob5 1497 14 to to TO cord-006856-b1w25ob5 1497 15 treat treat VB cord-006856-b1w25ob5 1497 16 infections infection NNS cord-006856-b1w25ob5 1497 17 . . . cord-006856-b1w25ob5 1498 1 Their -PRON- PRP$ cord-006856-b1w25ob5 1498 2 prevalence prevalence NN cord-006856-b1w25ob5 1498 3 in in IN cord-006856-b1w25ob5 1498 4 transplant transplant NN cord-006856-b1w25ob5 1498 5 surgical surgical JJ cord-006856-b1w25ob5 1498 6 site site NN cord-006856-b1w25ob5 1498 7 infection infection NN cord-006856-b1w25ob5 1498 8 thus thus RB cord-006856-b1w25ob5 1498 9 far far RB cord-006856-b1w25ob5 1498 10 might may MD cord-006856-b1w25ob5 1498 11 have have VB cord-006856-b1w25ob5 1498 12 been be VBN cord-006856-b1w25ob5 1498 13 underestimated underestimate VBN cord-006856-b1w25ob5 1498 14 . . . cord-006856-b1w25ob5 1499 1 Therefore therefore RB cord-006856-b1w25ob5 1499 2 , , , cord-006856-b1w25ob5 1499 3 we -PRON- PRP cord-006856-b1w25ob5 1499 4 recommend recommend VBP cord-006856-b1w25ob5 1499 5 empiric empiric JJ cord-006856-b1w25ob5 1499 6 antibiotic antibiotic JJ cord-006856-b1w25ob5 1499 7 treatment treatment NN cord-006856-b1w25ob5 1499 8 for for IN cord-006856-b1w25ob5 1499 9 sufficiently sufficiently RB cord-006856-b1w25ob5 1499 10 long long JJ cord-006856-b1w25ob5 1499 11 time time NN cord-006856-b1w25ob5 1499 12 in in IN cord-006856-b1w25ob5 1499 13 combination combination NN cord-006856-b1w25ob5 1499 14 with with IN cord-006856-b1w25ob5 1499 15 surgical surgical JJ cord-006856-b1w25ob5 1499 16 intervention intervention NN cord-006856-b1w25ob5 1499 17 when when WRB cord-006856-b1w25ob5 1499 18 necessary necessary JJ cord-006856-b1w25ob5 1499 19 . . . cord-006856-b1w25ob5 1500 1 Background background NN cord-006856-b1w25ob5 1500 2 . . . cord-006856-b1w25ob5 1501 1 By by IN cord-006856-b1w25ob5 1501 2 using use VBG cord-006856-b1w25ob5 1501 3 intensified intensify VBN cord-006856-b1w25ob5 1501 4 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1501 5 protocols protocol NNS cord-006856-b1w25ob5 1501 6 the the DT cord-006856-b1w25ob5 1501 7 incidence incidence NN cord-006856-b1w25ob5 1501 8 of of IN cord-006856-b1w25ob5 1501 9 immunological immunological JJ cord-006856-b1w25ob5 1501 10 complications complication NNS cord-006856-b1w25ob5 1501 11 after after IN cord-006856-b1w25ob5 1501 12 solid solid JJ cord-006856-b1w25ob5 1501 13 - - HYPH cord-006856-b1w25ob5 1501 14 organ organ NN cord-006856-b1w25ob5 1501 15 transplantation transplantation NN cord-006856-b1w25ob5 1501 16 has have VBZ cord-006856-b1w25ob5 1501 17 constantly constantly RB cord-006856-b1w25ob5 1501 18 declined decline VBN cord-006856-b1w25ob5 1501 19 . . . cord-006856-b1w25ob5 1502 1 However however RB cord-006856-b1w25ob5 1502 2 , , , cord-006856-b1w25ob5 1502 3 the the DT cord-006856-b1w25ob5 1502 4 incidence incidence NN cord-006856-b1w25ob5 1502 5 of of IN cord-006856-b1w25ob5 1502 6 some some DT cord-006856-b1w25ob5 1502 7 infections infection NNS cord-006856-b1w25ob5 1502 8 , , , cord-006856-b1w25ob5 1502 9 in in IN cord-006856-b1w25ob5 1502 10 particular particular JJ cord-006856-b1w25ob5 1502 11 complicated complicated JJ cord-006856-b1w25ob5 1502 12 fungal fungal JJ cord-006856-b1w25ob5 1502 13 infections infection NNS cord-006856-b1w25ob5 1502 14 , , , cord-006856-b1w25ob5 1502 15 seems seem VBZ cord-006856-b1w25ob5 1502 16 to to TO cord-006856-b1w25ob5 1502 17 increase increase VB cord-006856-b1w25ob5 1502 18 . . . cord-006856-b1w25ob5 1503 1 Candida Candida NNP cord-006856-b1w25ob5 1503 2 krusei krusei NNP cord-006856-b1w25ob5 1503 3 ( ( -LRB- cord-006856-b1w25ob5 1503 4 CK CK NNP cord-006856-b1w25ob5 1503 5 ) ) -RRB- cord-006856-b1w25ob5 1503 6 is be VBZ cord-006856-b1w25ob5 1503 7 resistant resistant JJ cord-006856-b1w25ob5 1503 8 to to IN cord-006856-b1w25ob5 1503 9 Fluconazole Fluconazole NNP cord-006856-b1w25ob5 1503 10 and and CC cord-006856-b1w25ob5 1503 11 recently recently RB cord-006856-b1w25ob5 1503 12 this this DT cord-006856-b1w25ob5 1503 13 pathogen pathogen NN cord-006856-b1w25ob5 1503 14 has have VBZ cord-006856-b1w25ob5 1503 15 been be VBN cord-006856-b1w25ob5 1503 16 more more RBR cord-006856-b1w25ob5 1503 17 commonly commonly RB cord-006856-b1w25ob5 1503 18 isolated isolate VBN cord-006856-b1w25ob5 1503 19 in in IN cord-006856-b1w25ob5 1503 20 severe severe JJ cord-006856-b1w25ob5 1503 21 infections infection NNS cord-006856-b1w25ob5 1503 22 , , , cord-006856-b1w25ob5 1503 23 particularly particularly RB cord-006856-b1w25ob5 1503 24 in in IN cord-006856-b1w25ob5 1503 25 the the DT cord-006856-b1w25ob5 1503 26 immunocompromised immunocompromised JJ cord-006856-b1w25ob5 1503 27 host host NN cord-006856-b1w25ob5 1503 28 . . . cord-006856-b1w25ob5 1504 1 Methods method NNS cord-006856-b1w25ob5 1504 2 . . . cord-006856-b1w25ob5 1505 1 Between between IN cord-006856-b1w25ob5 1505 2 1 1 CD cord-006856-b1w25ob5 1505 3 . . CD cord-006856-b1w25ob5 1505 4 1 1 CD cord-006856-b1w25ob5 1505 5 . . . cord-006856-b1w25ob5 1505 6 2004 2004 CD cord-006856-b1w25ob5 1505 7 and and CC cord-006856-b1w25ob5 1505 8 30 30 CD cord-006856-b1w25ob5 1505 9 . . . cord-006856-b1w25ob5 1505 10 6 6 CD cord-006856-b1w25ob5 1505 11 . . . cord-006856-b1w25ob5 1505 12 2005 2005 CD cord-006856-b1w25ob5 1505 13 , , , cord-006856-b1w25ob5 1505 14 a a DT cord-006856-b1w25ob5 1505 15 total total NN cord-006856-b1w25ob5 1505 16 of of IN cord-006856-b1w25ob5 1505 17 400 400 CD cord-006856-b1w25ob5 1505 18 solid solid JJ cord-006856-b1w25ob5 1505 19 - - HYPH cord-006856-b1w25ob5 1505 20 organ organ NN cord-006856-b1w25ob5 1505 21 transplants transplant NNS cord-006856-b1w25ob5 1505 22 were be VBD cord-006856-b1w25ob5 1505 23 performed perform VBN cord-006856-b1w25ob5 1505 24 at at IN cord-006856-b1w25ob5 1505 25 the the DT cord-006856-b1w25ob5 1505 26 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 1505 27 Medical Medical NNP cord-006856-b1w25ob5 1505 28 University University NNP cord-006856-b1w25ob5 1505 29 . . . cord-006856-b1w25ob5 1506 1 This this DT cord-006856-b1w25ob5 1506 2 included include VBD cord-006856-b1w25ob5 1506 3 150 150 CD cord-006856-b1w25ob5 1506 4 renal renal JJ cord-006856-b1w25ob5 1506 5 , , , cord-006856-b1w25ob5 1506 6 70 70 CD cord-006856-b1w25ob5 1506 7 liver liver NN cord-006856-b1w25ob5 1506 8 , , , cord-006856-b1w25ob5 1506 9 50 50 CD cord-006856-b1w25ob5 1506 10 pancreas pancrea NNS cord-006856-b1w25ob5 1506 11 , , , cord-006856-b1w25ob5 1506 12 5 5 CD cord-006856-b1w25ob5 1506 13 intestinal intestinal JJ cord-006856-b1w25ob5 1506 14 , , , cord-006856-b1w25ob5 1506 15 30 30 CD cord-006856-b1w25ob5 1506 16 cardiac cardiac NN cord-006856-b1w25ob5 1506 17 , , , cord-006856-b1w25ob5 1506 18 20 20 CD cord-006856-b1w25ob5 1506 19 lung lung NN cord-006856-b1w25ob5 1506 20 , , , cord-006856-b1w25ob5 1506 21 and and CC cord-006856-b1w25ob5 1506 22 10 10 CD cord-006856-b1w25ob5 1506 23 islet islet NN cord-006856-b1w25ob5 1506 24 transplants transplant NNS cord-006856-b1w25ob5 1506 25 . . . cord-006856-b1w25ob5 1507 1 Prophylactic prophylactic JJ cord-006856-b1w25ob5 1507 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1507 3 consisted consist VBD cord-006856-b1w25ob5 1507 4 of of IN cord-006856-b1w25ob5 1507 5 Calcineurin Calcineurin NNP cord-006856-b1w25ob5 1507 6 inhibitor inhibitor NN cord-006856-b1w25ob5 1507 7 - - HYPH cord-006856-b1w25ob5 1507 8 based base VBN cord-006856-b1w25ob5 1507 9 triple triple JJ cord-006856-b1w25ob5 1507 10 drug drug NN cord-006856-b1w25ob5 1507 11 therapy therapy NN cord-006856-b1w25ob5 1507 12 for for IN cord-006856-b1w25ob5 1507 13 the the DT cord-006856-b1w25ob5 1507 14 majority majority NN cord-006856-b1w25ob5 1507 15 of of IN cord-006856-b1w25ob5 1507 16 cases case NNS cord-006856-b1w25ob5 1507 17 . . . cord-006856-b1w25ob5 1508 1 Antifungal antifungal JJ cord-006856-b1w25ob5 1508 2 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1508 3 was be VBD cord-006856-b1w25ob5 1508 4 given give VBN cord-006856-b1w25ob5 1508 5 to to IN cord-006856-b1w25ob5 1508 6 all all DT cord-006856-b1w25ob5 1508 7 pancreatic pancreatic JJ cord-006856-b1w25ob5 1508 8 and and CC cord-006856-b1w25ob5 1508 9 intestinal intestinal JJ cord-006856-b1w25ob5 1508 10 recipients recipient NNS cord-006856-b1w25ob5 1508 11 ( ( -LRB- cord-006856-b1w25ob5 1508 12 Fluconazole fluconazole NN cord-006856-b1w25ob5 1508 13 400 400 CD cord-006856-b1w25ob5 1508 14 mg mg NN cord-006856-b1w25ob5 1508 15 per per IN cord-006856-b1w25ob5 1508 16 day day NN cord-006856-b1w25ob5 1508 17 ) ) -RRB- cord-006856-b1w25ob5 1508 18 and and CC cord-006856-b1w25ob5 1508 19 to to IN cord-006856-b1w25ob5 1508 20 all all DT cord-006856-b1w25ob5 1508 21 patients patient NNS cord-006856-b1w25ob5 1508 22 considered consider VBN cord-006856-b1w25ob5 1508 23 at at IN cord-006856-b1w25ob5 1508 24 high high JJ cord-006856-b1w25ob5 1508 25 risk risk NN cord-006856-b1w25ob5 1508 26 for for IN cord-006856-b1w25ob5 1508 27 filamentous filamentous JJ cord-006856-b1w25ob5 1508 28 - - HYPH cord-006856-b1w25ob5 1508 29 fungal fungal JJ cord-006856-b1w25ob5 1508 30 infections infection NNS cord-006856-b1w25ob5 1509 1 ( ( -LRB- cord-006856-b1w25ob5 1509 2 Ambisome Ambisome NNP cord-006856-b1w25ob5 1509 3 3 3 CD cord-006856-b1w25ob5 1509 4 mg mg NNP cord-006856-b1w25ob5 1509 5 / / SYM cord-006856-b1w25ob5 1509 6 kg kg NNP cord-006856-b1w25ob5 1509 7 ) ) -RRB- cord-006856-b1w25ob5 1509 8 . . . cord-006856-b1w25ob5 1510 1 Results result NNS cord-006856-b1w25ob5 1510 2 . . . cord-006856-b1w25ob5 1511 1 A a DT cord-006856-b1w25ob5 1511 2 total total NN cord-006856-b1w25ob5 1511 3 of of IN cord-006856-b1w25ob5 1511 4 five five CD cord-006856-b1w25ob5 1511 5 patients patient NNS cord-006856-b1w25ob5 1511 6 with with IN cord-006856-b1w25ob5 1511 7 CK CK NNP cord-006856-b1w25ob5 1511 8 infection infection NN cord-006856-b1w25ob5 1511 9 were be VBD cord-006856-b1w25ob5 1511 10 identified identify VBN cord-006856-b1w25ob5 1511 11 within within IN cord-006856-b1w25ob5 1511 12 this this DT cord-006856-b1w25ob5 1511 13 series series NN cord-006856-b1w25ob5 1511 14 ( ( -LRB- cord-006856-b1w25ob5 1511 15 2 2 CD cord-006856-b1w25ob5 1511 16 % % NN cord-006856-b1w25ob5 1511 17 ) ) -RRB- cord-006856-b1w25ob5 1511 18 . . . cord-006856-b1w25ob5 1512 1 Five five CD cord-006856-b1w25ob5 1512 2 patients patient NNS cord-006856-b1w25ob5 1512 3 developed develop VBD cord-006856-b1w25ob5 1512 4 infection infection NN cord-006856-b1w25ob5 1512 5 with with IN cord-006856-b1w25ob5 1512 6 Candida Candida NNP cord-006856-b1w25ob5 1512 7 tropicalis tropicalis NNP cord-006856-b1w25ob5 1512 8 and and CC cord-006856-b1w25ob5 1512 9 three three CD cord-006856-b1w25ob5 1512 10 with with IN cord-006856-b1w25ob5 1512 11 Candida Candida NNP cord-006856-b1w25ob5 1512 12 glabrata glabrata NNP cord-006856-b1w25ob5 1512 13 . . . cord-006856-b1w25ob5 1513 1 Within within IN cord-006856-b1w25ob5 1513 2 this this DT cord-006856-b1w25ob5 1513 3 time time NN cord-006856-b1w25ob5 1513 4 period period NN cord-006856-b1w25ob5 1513 5 , , , cord-006856-b1w25ob5 1513 6 another another DT cord-006856-b1w25ob5 1513 7 two two CD cord-006856-b1w25ob5 1513 8 patients patient NNS cord-006856-b1w25ob5 1513 9 with with IN cord-006856-b1w25ob5 1513 10 CK CK NNP cord-006856-b1w25ob5 1513 11 infection infection NN cord-006856-b1w25ob5 1513 12 were be VBD cord-006856-b1w25ob5 1513 13 identified identify VBN cord-006856-b1w25ob5 1513 14 , , , cord-006856-b1w25ob5 1513 15 one one PRP cord-006856-b1w25ob5 1513 16 had have VBD cord-006856-b1w25ob5 1513 17 a a DT cord-006856-b1w25ob5 1513 18 pleural pleural JJ cord-006856-b1w25ob5 1513 19 empyema empyema NN cord-006856-b1w25ob5 1513 20 following follow VBG cord-006856-b1w25ob5 1513 21 esophageal esophageal JJ cord-006856-b1w25ob5 1513 22 perforation perforation NN cord-006856-b1w25ob5 1513 23 and and CC cord-006856-b1w25ob5 1513 24 the the DT cord-006856-b1w25ob5 1513 25 other other JJ cord-006856-b1w25ob5 1513 26 was be VBD cord-006856-b1w25ob5 1513 27 treated treat VBN cord-006856-b1w25ob5 1513 28 with with IN cord-006856-b1w25ob5 1513 29 a a DT cord-006856-b1w25ob5 1513 30 ventricular ventricular JJ cord-006856-b1w25ob5 1513 31 assist assist VB cord-006856-b1w25ob5 1513 32 device device NN cord-006856-b1w25ob5 1513 33 and and CC cord-006856-b1w25ob5 1513 34 developed develop VBN cord-006856-b1w25ob5 1513 35 pulmonary pulmonary JJ cord-006856-b1w25ob5 1513 36 infection infection NN cord-006856-b1w25ob5 1513 37 with with IN cord-006856-b1w25ob5 1513 38 CK CK NNP cord-006856-b1w25ob5 1513 39 . . . cord-006856-b1w25ob5 1514 1 Both both DT cord-006856-b1w25ob5 1514 2 patients patient NNS cord-006856-b1w25ob5 1514 3 were be VBD cord-006856-b1w25ob5 1514 4 treated treat VBN cord-006856-b1w25ob5 1514 5 on on IN cord-006856-b1w25ob5 1514 6 the the DT cord-006856-b1w25ob5 1514 7 transplant transplant NN cord-006856-b1w25ob5 1514 8 intensive intensive JJ cord-006856-b1w25ob5 1514 9 care care NN cord-006856-b1w25ob5 1514 10 unit unit NN cord-006856-b1w25ob5 1514 11 . . . cord-006856-b1w25ob5 1515 1 The the DT cord-006856-b1w25ob5 1515 2 transplant transplant NN cord-006856-b1w25ob5 1515 3 patients patient NNS cord-006856-b1w25ob5 1515 4 were be VBD cord-006856-b1w25ob5 1515 5 three three CD cord-006856-b1w25ob5 1515 6 pancreas pancrea NNS cord-006856-b1w25ob5 1515 7 , , , cord-006856-b1w25ob5 1515 8 one one CD cord-006856-b1w25ob5 1515 9 liver liver NN cord-006856-b1w25ob5 1515 10 , , , cord-006856-b1w25ob5 1515 11 and and CC cord-006856-b1w25ob5 1515 12 one one CD cord-006856-b1w25ob5 1515 13 lung lung NN cord-006856-b1w25ob5 1515 14 recipient recipient NN cord-006856-b1w25ob5 1515 15 . . . cord-006856-b1w25ob5 1516 1 All all DT cord-006856-b1w25ob5 1516 2 three three CD cord-006856-b1w25ob5 1516 3 pancreas pancreas NN cord-006856-b1w25ob5 1516 4 recipients recipient NNS cord-006856-b1w25ob5 1516 5 were be VBD cord-006856-b1w25ob5 1516 6 diagnosed diagnose VBN cord-006856-b1w25ob5 1516 7 intra intra JJ cord-006856-b1w25ob5 1516 8 - - JJ cord-006856-b1w25ob5 1516 9 abdominal abdominal JJ cord-006856-b1w25ob5 1516 10 infection infection NN cord-006856-b1w25ob5 1516 11 , , , cord-006856-b1w25ob5 1516 12 the the DT cord-006856-b1w25ob5 1516 13 liver liver NN cord-006856-b1w25ob5 1516 14 recipient recipient NN cord-006856-b1w25ob5 1516 15 had have VBD cord-006856-b1w25ob5 1516 16 an an DT cord-006856-b1w25ob5 1516 17 ischemic ischemic JJ cord-006856-b1w25ob5 1516 18 cholangiopathy cholangiopathy NN cord-006856-b1w25ob5 1516 19 with with IN cord-006856-b1w25ob5 1516 20 CK CK NNP cord-006856-b1w25ob5 1516 21 cholangitis cholangitis NN cord-006856-b1w25ob5 1516 22 and and CC cord-006856-b1w25ob5 1516 23 required require VBD cord-006856-b1w25ob5 1516 24 retransplantation retransplantation NN cord-006856-b1w25ob5 1516 25 , , , cord-006856-b1w25ob5 1516 26 and and CC cord-006856-b1w25ob5 1516 27 the the DT cord-006856-b1w25ob5 1516 28 lung lung NN cord-006856-b1w25ob5 1516 29 recipient recipient NN cord-006856-b1w25ob5 1516 30 developed develop VBD cord-006856-b1w25ob5 1516 31 postoperative postoperative JJ cord-006856-b1w25ob5 1516 32 hemorrhage hemorrhage NN cord-006856-b1w25ob5 1516 33 and and CC cord-006856-b1w25ob5 1516 34 subsequently subsequently RB cord-006856-b1w25ob5 1516 35 CK CK NNP cord-006856-b1w25ob5 1516 36 pleural pleural JJ cord-006856-b1w25ob5 1516 37 empyema empyema NN cord-006856-b1w25ob5 1516 38 . . . cord-006856-b1w25ob5 1517 1 All all DT cord-006856-b1w25ob5 1517 2 patients patient NNS cord-006856-b1w25ob5 1517 3 presented present VBN cord-006856-b1w25ob5 1517 4 also also RB cord-006856-b1w25ob5 1517 5 with with IN cord-006856-b1w25ob5 1517 6 other other JJ cord-006856-b1w25ob5 1517 7 infectious infectious JJ cord-006856-b1w25ob5 1517 8 complications complication NNS cord-006856-b1w25ob5 1517 9 . . . cord-006856-b1w25ob5 1518 1 Treatment treatment NN cord-006856-b1w25ob5 1518 2 of of IN cord-006856-b1w25ob5 1518 3 CK CK NNP cord-006856-b1w25ob5 1518 4 infection infection NN cord-006856-b1w25ob5 1518 5 consisted consist VBD cord-006856-b1w25ob5 1518 6 in in IN cord-006856-b1w25ob5 1518 7 four four CD cord-006856-b1w25ob5 1518 8 cases case NNS cord-006856-b1w25ob5 1518 9 of of IN cord-006856-b1w25ob5 1518 10 Caspofungin Caspofungin NNP cord-006856-b1w25ob5 1518 11 or or CC cord-006856-b1w25ob5 1518 12 Voriconazole Voriconazole NNP cord-006856-b1w25ob5 1518 13 or or CC cord-006856-b1w25ob5 1518 14 combination combination NN cord-006856-b1w25ob5 1518 15 of of IN cord-006856-b1w25ob5 1518 16 the the DT cord-006856-b1w25ob5 1518 17 two two CD cord-006856-b1w25ob5 1518 18 , , , cord-006856-b1w25ob5 1518 19 and and CC cord-006856-b1w25ob5 1518 20 in in IN cord-006856-b1w25ob5 1518 21 one one CD cord-006856-b1w25ob5 1518 22 case case NN cord-006856-b1w25ob5 1518 23 , , , cord-006856-b1w25ob5 1518 24 CK CK NNP cord-006856-b1w25ob5 1518 25 was be VBD cord-006856-b1w25ob5 1518 26 isolated isolate VBN cord-006856-b1w25ob5 1518 27 from from IN cord-006856-b1w25ob5 1518 28 infected infected JJ cord-006856-b1w25ob5 1518 29 hematoma hematoma NN cord-006856-b1w25ob5 1518 30 and and CC cord-006856-b1w25ob5 1518 31 did do VBD cord-006856-b1w25ob5 1518 32 not not RB cord-006856-b1w25ob5 1518 33 require require VB cord-006856-b1w25ob5 1518 34 antifungal antifungal JJ cord-006856-b1w25ob5 1518 35 therapy therapy NN cord-006856-b1w25ob5 1518 36 after after IN cord-006856-b1w25ob5 1518 37 surgical surgical JJ cord-006856-b1w25ob5 1518 38 removal removal NN cord-006856-b1w25ob5 1518 39 . . . cord-006856-b1w25ob5 1519 1 All all DT cord-006856-b1w25ob5 1519 2 infected infected JJ cord-006856-b1w25ob5 1519 3 collections collection NNS cord-006856-b1w25ob5 1519 4 were be VBD cord-006856-b1w25ob5 1519 5 evacuated evacuate VBN cord-006856-b1w25ob5 1519 6 either either CC cord-006856-b1w25ob5 1519 7 surgically surgically RB cord-006856-b1w25ob5 1519 8 ( ( -LRB- cord-006856-b1w25ob5 1519 9 n n NN cord-006856-b1w25ob5 1519 10 = = SYM cord-006856-b1w25ob5 1519 11 3 3 CD cord-006856-b1w25ob5 1519 12 ) ) -RRB- cord-006856-b1w25ob5 1519 13 or or CC cord-006856-b1w25ob5 1519 14 through through IN cord-006856-b1w25ob5 1519 15 pig pig NN cord-006856-b1w25ob5 1519 16 - - HYPH cord-006856-b1w25ob5 1519 17 tail tail NN cord-006856-b1w25ob5 1519 18 drainage drainage NN cord-006856-b1w25ob5 1519 19 ( ( -LRB- cord-006856-b1w25ob5 1519 20 n n NN cord-006856-b1w25ob5 1519 21 = = SYM cord-006856-b1w25ob5 1519 22 2 2 CD cord-006856-b1w25ob5 1519 23 ) ) -RRB- cord-006856-b1w25ob5 1519 24 . . . cord-006856-b1w25ob5 1520 1 CK CK NNP cord-006856-b1w25ob5 1520 2 infection infection NN cord-006856-b1w25ob5 1520 3 was be VBD cord-006856-b1w25ob5 1520 4 successfully successfully RB cord-006856-b1w25ob5 1520 5 managed manage VBN cord-006856-b1w25ob5 1520 6 in in IN cord-006856-b1w25ob5 1520 7 all all DT cord-006856-b1w25ob5 1520 8 cases case NNS cord-006856-b1w25ob5 1520 9 and and CC cord-006856-b1w25ob5 1520 10 patients patient NNS cord-006856-b1w25ob5 1520 11 are be VBP cord-006856-b1w25ob5 1520 12 currently currently RB cord-006856-b1w25ob5 1520 13 alive alive JJ cord-006856-b1w25ob5 1520 14 , , , cord-006856-b1w25ob5 1520 15 only only RB cord-006856-b1w25ob5 1520 16 one one CD cord-006856-b1w25ob5 1520 17 pancreas pancreas NN cord-006856-b1w25ob5 1520 18 graft graft NN cord-006856-b1w25ob5 1520 19 was be VBD cord-006856-b1w25ob5 1520 20 lost lose VBN cord-006856-b1w25ob5 1520 21 . . . cord-006856-b1w25ob5 1521 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1521 2 . . . cord-006856-b1w25ob5 1522 1 Candida Candida NNP cord-006856-b1w25ob5 1522 2 krusei krusei NN cord-006856-b1w25ob5 1522 3 infections infection NNS cord-006856-b1w25ob5 1522 4 now now RB cord-006856-b1w25ob5 1522 5 represent represent VBP cord-006856-b1w25ob5 1522 6 frequent frequent JJ cord-006856-b1w25ob5 1522 7 severe severe JJ cord-006856-b1w25ob5 1522 8 complications complication NNS cord-006856-b1w25ob5 1522 9 in in IN cord-006856-b1w25ob5 1522 10 solid solid JJ cord-006856-b1w25ob5 1522 11 - - HYPH cord-006856-b1w25ob5 1522 12 organ organ NN cord-006856-b1w25ob5 1522 13 recipients recipient NNS cord-006856-b1w25ob5 1522 14 . . . cord-006856-b1w25ob5 1523 1 However however RB cord-006856-b1w25ob5 1523 2 , , , cord-006856-b1w25ob5 1523 3 rapid rapid JJ cord-006856-b1w25ob5 1523 4 diagnosis diagnosis NN cord-006856-b1w25ob5 1523 5 and and CC cord-006856-b1w25ob5 1523 6 treatment treatment NN cord-006856-b1w25ob5 1523 7 with with IN cord-006856-b1w25ob5 1523 8 new new JJ cord-006856-b1w25ob5 1523 9 antifungal antifungal JJ cord-006856-b1w25ob5 1523 10 agents agent NNS cord-006856-b1w25ob5 1523 11 such such JJ cord-006856-b1w25ob5 1523 12 as as IN cord-006856-b1w25ob5 1523 13 Voriconazole Voriconazole NNP cord-006856-b1w25ob5 1523 14 , , , cord-006856-b1w25ob5 1523 15 Caspofungin Caspofungin NNP cord-006856-b1w25ob5 1523 16 , , , cord-006856-b1w25ob5 1523 17 or or CC cord-006856-b1w25ob5 1523 18 Ambisome Ambisome NNP cord-006856-b1w25ob5 1523 19 allow allow VB cord-006856-b1w25ob5 1523 20 successful successful JJ cord-006856-b1w25ob5 1523 21 therapy therapy NN cord-006856-b1w25ob5 1523 22 of of IN cord-006856-b1w25ob5 1523 23 these these DT cord-006856-b1w25ob5 1523 24 infections infection NNS cord-006856-b1w25ob5 1523 25 . . . cord-006856-b1w25ob5 1524 1 Solid solid JJ cord-006856-b1w25ob5 1524 2 - - HYPH cord-006856-b1w25ob5 1524 3 organ organ NN cord-006856-b1w25ob5 1524 4 recipients recipient NNS cord-006856-b1w25ob5 1524 5 seem seem VBP cord-006856-b1w25ob5 1524 6 to to TO cord-006856-b1w25ob5 1524 7 be be VB cord-006856-b1w25ob5 1524 8 at at IN cord-006856-b1w25ob5 1524 9 increasing increase VBG cord-006856-b1w25ob5 1524 10 risk risk NN cord-006856-b1w25ob5 1524 11 to to TO cord-006856-b1w25ob5 1524 12 acquire acquire VB cord-006856-b1w25ob5 1524 13 non non JJ cord-006856-b1w25ob5 1524 14 - - JJ cord-006856-b1w25ob5 1524 15 albicans albicans JJ cord-006856-b1w25ob5 1524 16 Candida Candida NNP cord-006856-b1w25ob5 1524 17 infections infection NNS cord-006856-b1w25ob5 1524 18 . . . cord-006856-b1w25ob5 1525 1 Background background NN cord-006856-b1w25ob5 1525 2 . . . cord-006856-b1w25ob5 1526 1 After after IN cord-006856-b1w25ob5 1526 2 solid solid JJ cord-006856-b1w25ob5 1526 3 - - HYPH cord-006856-b1w25ob5 1526 4 organ organ NN cord-006856-b1w25ob5 1526 5 transplantation transplantation NN cord-006856-b1w25ob5 1526 6 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1526 7 ( ( -LRB- cord-006856-b1w25ob5 1526 8 IS be VBZ cord-006856-b1w25ob5 1526 9 ) ) -RRB- cord-006856-b1w25ob5 1526 10 and and CC cord-006856-b1w25ob5 1526 11 concomitant concomitant JJ cord-006856-b1w25ob5 1526 12 infection infection NN cord-006856-b1w25ob5 1526 13 with with IN cord-006856-b1w25ob5 1526 14 CMV CMV NNP cord-006856-b1w25ob5 1526 15 , , , cord-006856-b1w25ob5 1526 16 EBV EBV NNP cord-006856-b1w25ob5 1526 17 , , , cord-006856-b1w25ob5 1526 18 HHV-6 HHV-6 NNP cord-006856-b1w25ob5 1526 19 , , , cord-006856-b1w25ob5 1526 20 -8 -8 NNP cord-006856-b1w25ob5 1526 21 , , , cord-006856-b1w25ob5 1526 22 or or CC cord-006856-b1w25ob5 1526 23 papillomavirus papillomavirus NN cord-006856-b1w25ob5 1526 24 put put VBD cord-006856-b1w25ob5 1526 25 patients patient NNS cord-006856-b1w25ob5 1526 26 at at IN cord-006856-b1w25ob5 1526 27 risk risk NN cord-006856-b1w25ob5 1526 28 for for IN cord-006856-b1w25ob5 1526 29 developing develop VBG cord-006856-b1w25ob5 1526 30 malignant malignant JJ cord-006856-b1w25ob5 1526 31 diseases disease NNS cord-006856-b1w25ob5 1526 32 ( ( -LRB- cord-006856-b1w25ob5 1526 33 14 14 CD cord-006856-b1w25ob5 1526 34 % % NN cord-006856-b1w25ob5 1526 35 cumulative cumulative JJ cord-006856-b1w25ob5 1526 36 risk risk NN cord-006856-b1w25ob5 1526 37 at at IN cord-006856-b1w25ob5 1526 38 10 10 CD cord-006856-b1w25ob5 1526 39 years year NNS cord-006856-b1w25ob5 1526 40 ; ; : cord-006856-b1w25ob5 1526 41 Adami Adami NNP cord-006856-b1w25ob5 1526 42 et et NNP cord-006856-b1w25ob5 1526 43 al al NNP cord-006856-b1w25ob5 1526 44 . . NNP cord-006856-b1w25ob5 1526 45 2003 2003 CD cord-006856-b1w25ob5 1526 46 ) ) -RRB- cord-006856-b1w25ob5 1526 47 . . . cord-006856-b1w25ob5 1527 1 Posttransplant posttransplant JJ cord-006856-b1w25ob5 1527 2 lymphoproliferative lymphoproliferative JJ cord-006856-b1w25ob5 1527 3 disorders disorder NNS cord-006856-b1w25ob5 1527 4 ( ( -LRB- cord-006856-b1w25ob5 1527 5 PTLD PTLD NNP cord-006856-b1w25ob5 1527 6 ) ) -RRB- cord-006856-b1w25ob5 1527 7 and and CC cord-006856-b1w25ob5 1527 8 skin skin NN cord-006856-b1w25ob5 1527 9 cancers cancer NNS cord-006856-b1w25ob5 1527 10 are be VBP cord-006856-b1w25ob5 1527 11 known know VBN cord-006856-b1w25ob5 1527 12 to to TO cord-006856-b1w25ob5 1527 13 have have VB cord-006856-b1w25ob5 1527 14 the the DT cord-006856-b1w25ob5 1527 15 highest high JJS cord-006856-b1w25ob5 1527 16 incidence incidence NN cord-006856-b1w25ob5 1527 17 in in IN cord-006856-b1w25ob5 1527 18 immunocompromised immunocompromised JJ cord-006856-b1w25ob5 1527 19 patients patient NNS cord-006856-b1w25ob5 1527 20 . . . cord-006856-b1w25ob5 1528 1 Reports report NNS cord-006856-b1w25ob5 1528 2 on on IN cord-006856-b1w25ob5 1528 3 colorectal colorectal JJ cord-006856-b1w25ob5 1528 4 cancer cancer NN cord-006856-b1w25ob5 1528 5 after after IN cord-006856-b1w25ob5 1528 6 different different JJ cord-006856-b1w25ob5 1528 7 types type NNS cord-006856-b1w25ob5 1528 8 of of IN cord-006856-b1w25ob5 1528 9 organ organ NN cord-006856-b1w25ob5 1528 10 transplantation transplantation NN cord-006856-b1w25ob5 1528 11 are be VBP cord-006856-b1w25ob5 1528 12 rare rare JJ cord-006856-b1w25ob5 1528 13 and and CC cord-006856-b1w25ob5 1528 14 the the DT cord-006856-b1w25ob5 1528 15 incidence incidence NN cord-006856-b1w25ob5 1528 16 was be VBD cord-006856-b1w25ob5 1528 17 0.01 0.01 CD cord-006856-b1w25ob5 1528 18 % % NN cord-006856-b1w25ob5 1528 19 to to IN cord-006856-b1w25ob5 1528 20 3.9 3.9 CD cord-006856-b1w25ob5 1528 21 % % NN cord-006856-b1w25ob5 1528 22 and and CC cord-006856-b1w25ob5 1528 23 did do VBD cord-006856-b1w25ob5 1528 24 not not RB cord-006856-b1w25ob5 1528 25 differ differ VB cord-006856-b1w25ob5 1528 26 from from IN cord-006856-b1w25ob5 1528 27 that that DT cord-006856-b1w25ob5 1528 28 of of IN cord-006856-b1w25ob5 1528 29 the the DT cord-006856-b1w25ob5 1528 30 normal normal JJ cord-006856-b1w25ob5 1528 31 population population NN cord-006856-b1w25ob5 1528 32 . . . cord-006856-b1w25ob5 1529 1 We -PRON- PRP cord-006856-b1w25ob5 1529 2 analysed analyse VBD cord-006856-b1w25ob5 1529 3 our -PRON- PRP$ cord-006856-b1w25ob5 1529 4 database database NN cord-006856-b1w25ob5 1529 5 with with IN cord-006856-b1w25ob5 1529 6 regard regard NN cord-006856-b1w25ob5 1529 7 to to IN cord-006856-b1w25ob5 1529 8 the the DT cord-006856-b1w25ob5 1529 9 incidence incidence NN cord-006856-b1w25ob5 1529 10 and and CC cord-006856-b1w25ob5 1529 11 course course NN cord-006856-b1w25ob5 1529 12 of of IN cord-006856-b1w25ob5 1529 13 colorectal colorectal JJ cord-006856-b1w25ob5 1529 14 malignancies malignancy NNS cord-006856-b1w25ob5 1529 15 following follow VBG cord-006856-b1w25ob5 1529 16 treatment treatment NN cord-006856-b1w25ob5 1529 17 and and CC cord-006856-b1w25ob5 1529 18 introduction introduction NN cord-006856-b1w25ob5 1529 19 of of IN cord-006856-b1w25ob5 1529 20 TOR TOR NNP cord-006856-b1w25ob5 1529 21 inhibitor inhibitor NN cord-006856-b1w25ob5 1529 22 - - HYPH cord-006856-b1w25ob5 1529 23 based base VBN cord-006856-b1w25ob5 1529 24 IS be VBZ cord-006856-b1w25ob5 1529 25 . . . cord-006856-b1w25ob5 1530 1 Methods method NNS cord-006856-b1w25ob5 1530 2 . . . cord-006856-b1w25ob5 1531 1 Medical medical JJ cord-006856-b1w25ob5 1531 2 records record NNS cord-006856-b1w25ob5 1531 3 of of IN cord-006856-b1w25ob5 1531 4 solid solid JJ cord-006856-b1w25ob5 1531 5 - - HYPH cord-006856-b1w25ob5 1531 6 organ organ NN cord-006856-b1w25ob5 1531 7 transplants transplant NNS cord-006856-b1w25ob5 1531 8 performed perform VBN cord-006856-b1w25ob5 1531 9 between between IN cord-006856-b1w25ob5 1531 10 1986 1986 CD cord-006856-b1w25ob5 1531 11 and and CC cord-006856-b1w25ob5 1531 12 2005 2005 CD cord-006856-b1w25ob5 1531 13 at at IN cord-006856-b1w25ob5 1531 14 our -PRON- PRP$ cord-006856-b1w25ob5 1531 15 center center NN cord-006856-b1w25ob5 1531 16 were be VBD cord-006856-b1w25ob5 1531 17 analysed analyse VBN cord-006856-b1w25ob5 1531 18 retrospectively retrospectively RB cord-006856-b1w25ob5 1531 19 . . . cord-006856-b1w25ob5 1532 1 In in IN cord-006856-b1w25ob5 1532 2 a a DT cord-006856-b1w25ob5 1532 3 total total NN cord-006856-b1w25ob5 1532 4 of of IN cord-006856-b1w25ob5 1532 5 3568 3568 CD cord-006856-b1w25ob5 1532 6 patients patient NNS cord-006856-b1w25ob5 1532 7 247 247 CD cord-006856-b1w25ob5 1532 8 heart heart NN cord-006856-b1w25ob5 1532 9 , , , cord-006856-b1w25ob5 1532 10 118 118 CD cord-006856-b1w25ob5 1532 11 lung lung NN cord-006856-b1w25ob5 1532 12 , , , cord-006856-b1w25ob5 1532 13 2074 2074 CD cord-006856-b1w25ob5 1532 14 kidney kidney NN cord-006856-b1w25ob5 1532 15 , , , cord-006856-b1w25ob5 1532 16 757 757 CD cord-006856-b1w25ob5 1532 17 liver liver NN cord-006856-b1w25ob5 1532 18 , , , cord-006856-b1w25ob5 1532 19 367 367 CD cord-006856-b1w25ob5 1532 20 pancreas pancrea NNS cord-006856-b1w25ob5 1532 21 , , , cord-006856-b1w25ob5 1532 22 and and CC cord-006856-b1w25ob5 1532 23 9 9 CD cord-006856-b1w25ob5 1532 24 combined combine VBN cord-006856-b1w25ob5 1532 25 heart heart NN cord-006856-b1w25ob5 1532 26 - - HYPH cord-006856-b1w25ob5 1532 27 lung lung NN cord-006856-b1w25ob5 1532 28 transplantations transplantation NNS cord-006856-b1w25ob5 1532 29 were be VBD cord-006856-b1w25ob5 1532 30 performed perform VBN cord-006856-b1w25ob5 1532 31 ( ( -LRB- cord-006856-b1w25ob5 1532 32 27 27 CD cord-006856-b1w25ob5 1532 33 small small JJ cord-006856-b1w25ob5 1532 34 bowel bowel NN cord-006856-b1w25ob5 1532 35 and and CC cord-006856-b1w25ob5 1532 36 4 4 CD cord-006856-b1w25ob5 1532 37 hand hand NN cord-006856-b1w25ob5 1532 38 transplantations transplantation NNS cord-006856-b1w25ob5 1532 39 not not RB cord-006856-b1w25ob5 1532 40 included include VBN cord-006856-b1w25ob5 1532 41 ) ) -RRB- cord-006856-b1w25ob5 1532 42 . . . cord-006856-b1w25ob5 1533 1 Immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1533 2 therapy therapy NN cord-006856-b1w25ob5 1533 3 consisted consist VBD cord-006856-b1w25ob5 1533 4 of of IN cord-006856-b1w25ob5 1533 5 triple triple JJ cord-006856-b1w25ob5 1533 6 therapy therapy NN cord-006856-b1w25ob5 1533 7 comprising comprise VBG cord-006856-b1w25ob5 1533 8 steroids steroid NNS cord-006856-b1w25ob5 1533 9 , , , cord-006856-b1w25ob5 1533 10 azathioprine azathioprine NN cord-006856-b1w25ob5 1533 11 / / SYM cord-006856-b1w25ob5 1533 12 MMF mmf NN cord-006856-b1w25ob5 1533 13 , , , cord-006856-b1w25ob5 1533 14 and and CC cord-006856-b1w25ob5 1533 15 CyA CyA NNP cord-006856-b1w25ob5 1533 16 / / SYM cord-006856-b1w25ob5 1533 17 Tac Tac NNP cord-006856-b1w25ob5 1533 18 . . . cord-006856-b1w25ob5 1534 1 Some some DT cord-006856-b1w25ob5 1534 2 of of IN cord-006856-b1w25ob5 1534 3 them -PRON- PRP cord-006856-b1w25ob5 1534 4 received receive VBD cord-006856-b1w25ob5 1534 5 induction induction NN cord-006856-b1w25ob5 1534 6 therapy therapy NN cord-006856-b1w25ob5 1534 7 with with IN cord-006856-b1w25ob5 1534 8 antithymocyte antithymocyte NNP cord-006856-b1w25ob5 1534 9 globulin globulin NNP cord-006856-b1w25ob5 1534 10 . . . cord-006856-b1w25ob5 1535 1 Results result NNS cord-006856-b1w25ob5 1535 2 . . . cord-006856-b1w25ob5 1536 1 A a DT cord-006856-b1w25ob5 1536 2 total total NN cord-006856-b1w25ob5 1536 3 of of IN cord-006856-b1w25ob5 1536 4 206 206 CD cord-006856-b1w25ob5 1536 5 patients patient NNS cord-006856-b1w25ob5 1536 6 ( ( -LRB- cord-006856-b1w25ob5 1536 7 5.72 5.72 CD cord-006856-b1w25ob5 1536 8 % % NN cord-006856-b1w25ob5 1536 9 ) ) -RRB- cord-006856-b1w25ob5 1536 10 developed develop VBN cord-006856-b1w25ob5 1536 11 malignancies malignancy NNS cord-006856-b1w25ob5 1536 12 . . . cord-006856-b1w25ob5 1537 1 Of of IN cord-006856-b1w25ob5 1537 2 them -PRON- PRP cord-006856-b1w25ob5 1537 3 , , , cord-006856-b1w25ob5 1537 4 9 9 CD cord-006856-b1w25ob5 1537 5 patients patient NNS cord-006856-b1w25ob5 1537 6 ( ( -LRB- cord-006856-b1w25ob5 1537 7 1 1 CD cord-006856-b1w25ob5 1537 8 female female JJ cord-006856-b1w25ob5 1537 9 , , , cord-006856-b1w25ob5 1537 10 8 8 CD cord-006856-b1w25ob5 1537 11 male male NN cord-006856-b1w25ob5 1537 12 ; ; : cord-006856-b1w25ob5 1537 13 median median JJ cord-006856-b1w25ob5 1537 14 age age NN cord-006856-b1w25ob5 1537 15 at at IN cord-006856-b1w25ob5 1537 16 diagnosis diagnosis NN cord-006856-b1w25ob5 1537 17 , , , cord-006856-b1w25ob5 1537 18 66.1 66.1 CD cord-006856-b1w25ob5 1537 19 years year NNS cord-006856-b1w25ob5 1537 20 ; ; : cord-006856-b1w25ob5 1537 21 2 2 CD cord-006856-b1w25ob5 1537 22 kidney kidney NN cord-006856-b1w25ob5 1537 23 , , , cord-006856-b1w25ob5 1537 24 3 3 CD cord-006856-b1w25ob5 1537 25 heart heart NN cord-006856-b1w25ob5 1537 26 , , , cord-006856-b1w25ob5 1537 27 4 4 CD cord-006856-b1w25ob5 1537 28 liver liver NN cord-006856-b1w25ob5 1537 29 recipients recipient NNS cord-006856-b1w25ob5 1537 30 ) ) -RRB- cord-006856-b1w25ob5 1537 31 had have VBD cord-006856-b1w25ob5 1537 32 colorectal colorectal JJ cord-006856-b1w25ob5 1537 33 malignancies malignancy NNS cord-006856-b1w25ob5 1537 34 ( ( -LRB- cord-006856-b1w25ob5 1537 35 0.25 0.25 CD cord-006856-b1w25ob5 1537 36 % % NN cord-006856-b1w25ob5 1537 37 ) ) -RRB- cord-006856-b1w25ob5 1537 38 during during IN cord-006856-b1w25ob5 1537 39 a a DT cord-006856-b1w25ob5 1537 40 mean mean JJ cord-006856-b1w25ob5 1537 41 follow follow NN cord-006856-b1w25ob5 1537 42 - - HYPH cord-006856-b1w25ob5 1537 43 up up NN cord-006856-b1w25ob5 1537 44 period period NN cord-006856-b1w25ob5 1537 45 of of IN cord-006856-b1w25ob5 1537 46 7.3 7.3 CD cord-006856-b1w25ob5 1537 47 years year NNS cord-006856-b1w25ob5 1537 48 . . . cord-006856-b1w25ob5 1538 1 On on IN cord-006856-b1w25ob5 1538 2 average average JJ cord-006856-b1w25ob5 1538 3 , , , cord-006856-b1w25ob5 1538 4 diagnosis diagnosis NN cord-006856-b1w25ob5 1538 5 was be VBD cord-006856-b1w25ob5 1538 6 made make VBN cord-006856-b1w25ob5 1538 7 5.8 5.8 CD cord-006856-b1w25ob5 1538 8 years year NNS cord-006856-b1w25ob5 1538 9 after after IN cord-006856-b1w25ob5 1538 10 transplantation transplantation NN cord-006856-b1w25ob5 1538 11 . . . cord-006856-b1w25ob5 1539 1 Four four CD cord-006856-b1w25ob5 1539 2 carcinomas carcinoma NNS cord-006856-b1w25ob5 1539 3 were be VBD cord-006856-b1w25ob5 1539 4 located locate VBN cord-006856-b1w25ob5 1539 5 in in IN cord-006856-b1w25ob5 1539 6 the the DT cord-006856-b1w25ob5 1539 7 rectum rectum NN cord-006856-b1w25ob5 1539 8 or or CC cord-006856-b1w25ob5 1539 9 at at IN cord-006856-b1w25ob5 1539 10 the the DT cord-006856-b1w25ob5 1539 11 rectosigmoid rectosigmoid NNP cord-006856-b1w25ob5 1539 12 junction junction NN cord-006856-b1w25ob5 1539 13 and and CC cord-006856-b1w25ob5 1539 14 five five CD cord-006856-b1w25ob5 1539 15 were be VBD cord-006856-b1w25ob5 1539 16 colon colon NN cord-006856-b1w25ob5 1539 17 cancers cancer NNS cord-006856-b1w25ob5 1539 18 ( ( -LRB- cord-006856-b1w25ob5 1539 19 five five CD cord-006856-b1w25ob5 1539 20 pT3 pt3 NN cord-006856-b1w25ob5 1539 21 , , , cord-006856-b1w25ob5 1539 22 one one CD cord-006856-b1w25ob5 1539 23 pT2 pt2 NN cord-006856-b1w25ob5 1539 24 , , , cord-006856-b1w25ob5 1539 25 and and CC cord-006856-b1w25ob5 1539 26 three three CD cord-006856-b1w25ob5 1539 27 pT1 pt1 JJ cord-006856-b1w25ob5 1539 28 stages stage NNS cord-006856-b1w25ob5 1539 29 ) ) -RRB- cord-006856-b1w25ob5 1539 30 . . . cord-006856-b1w25ob5 1540 1 R0 R0 NNP cord-006856-b1w25ob5 1540 2 resection resection NN cord-006856-b1w25ob5 1540 3 was be VBD cord-006856-b1w25ob5 1540 4 performed perform VBN cord-006856-b1w25ob5 1540 5 in in IN cord-006856-b1w25ob5 1540 6 all all DT cord-006856-b1w25ob5 1540 7 9 9 CD cord-006856-b1w25ob5 1540 8 patients patient NNS cord-006856-b1w25ob5 1540 9 plus plus CC cord-006856-b1w25ob5 1540 10 radio radio NN cord-006856-b1w25ob5 1540 11 - - HYPH cord-006856-b1w25ob5 1540 12 and and CC cord-006856-b1w25ob5 1540 13 / / SYM cord-006856-b1w25ob5 1540 14 or or CC cord-006856-b1w25ob5 1540 15 chemotherapy chemotherapy NN cord-006856-b1w25ob5 1540 16 in in IN cord-006856-b1w25ob5 1540 17 all all DT cord-006856-b1w25ob5 1540 18 T3 T3 NNP cord-006856-b1w25ob5 1540 19 stages stage NNS cord-006856-b1w25ob5 1540 20 . . . cord-006856-b1w25ob5 1541 1 Five five CD cord-006856-b1w25ob5 1541 2 patients patient NNS cord-006856-b1w25ob5 1541 3 ( ( -LRB- cord-006856-b1w25ob5 1541 4 55 55 CD cord-006856-b1w25ob5 1541 5 % % NN cord-006856-b1w25ob5 1541 6 ) ) -RRB- cord-006856-b1w25ob5 1541 7 died die VBD cord-006856-b1w25ob5 1541 8 7.2 7.2 CD cord-006856-b1w25ob5 1541 9 years year NNS cord-006856-b1w25ob5 1541 10 post post NN cord-006856-b1w25ob5 1541 11 transplant transplant NN cord-006856-b1w25ob5 1541 12 due due IN cord-006856-b1w25ob5 1541 13 to to IN cord-006856-b1w25ob5 1541 14 cardiovascular cardiovascular JJ cord-006856-b1w25ob5 1541 15 disease disease NN cord-006856-b1w25ob5 1541 16 ( ( -LRB- cord-006856-b1w25ob5 1541 17 n n NN cord-006856-b1w25ob5 1541 18 = = SYM cord-006856-b1w25ob5 1541 19 4 4 CD cord-006856-b1w25ob5 1541 20 ) ) -RRB- cord-006856-b1w25ob5 1541 21 and and CC cord-006856-b1w25ob5 1541 22 recurrent recurrent JJ cord-006856-b1w25ob5 1541 23 tumor tumor NN cord-006856-b1w25ob5 1541 24 disease disease NN cord-006856-b1w25ob5 1541 25 ( ( -LRB- cord-006856-b1w25ob5 1541 26 n n NN cord-006856-b1w25ob5 1541 27 = = SYM cord-006856-b1w25ob5 1541 28 1 1 CD cord-006856-b1w25ob5 1541 29 ) ) -RRB- cord-006856-b1w25ob5 1541 30 . . . cord-006856-b1w25ob5 1542 1 The the DT cord-006856-b1w25ob5 1542 2 1-year 1-year CD cord-006856-b1w25ob5 1542 3 survival survival NN cord-006856-b1w25ob5 1542 4 rate rate NN cord-006856-b1w25ob5 1542 5 was be VBD cord-006856-b1w25ob5 1542 6 67 67 CD cord-006856-b1w25ob5 1542 7 % % NN cord-006856-b1w25ob5 1542 8 for for IN cord-006856-b1w25ob5 1542 9 T3 T3 NNP cord-006856-b1w25ob5 1542 10 and and CC cord-006856-b1w25ob5 1542 11 100 100 CD cord-006856-b1w25ob5 1542 12 % % NN cord-006856-b1w25ob5 1542 13 for for IN cord-006856-b1w25ob5 1542 14 T1 t1 NN cord-006856-b1w25ob5 1542 15 rectal rectal JJ cord-006856-b1w25ob5 1542 16 cancers cancer NNS cord-006856-b1w25ob5 1542 17 , , , cord-006856-b1w25ob5 1542 18 50 50 CD cord-006856-b1w25ob5 1542 19 % % NN cord-006856-b1w25ob5 1542 20 for for IN cord-006856-b1w25ob5 1542 21 T3 T3 NNP cord-006856-b1w25ob5 1542 22 and and CC cord-006856-b1w25ob5 1542 23 T1 T1 NNP cord-006856-b1w25ob5 1542 24 each each DT cord-006856-b1w25ob5 1542 25 and and CC cord-006856-b1w25ob5 1542 26 100 100 CD cord-006856-b1w25ob5 1542 27 % % NN cord-006856-b1w25ob5 1542 28 for for IN cord-006856-b1w25ob5 1542 29 the the DT cord-006856-b1w25ob5 1542 30 only only JJ cord-006856-b1w25ob5 1542 31 T2 T2 NNP cord-006856-b1w25ob5 1542 32 colon colon NN cord-006856-b1w25ob5 1542 33 cancer cancer NN cord-006856-b1w25ob5 1542 34 . . . cord-006856-b1w25ob5 1543 1 Three three CD cord-006856-b1w25ob5 1543 2 anal anal JJ cord-006856-b1w25ob5 1543 3 neoplasms neoplasm NNS cord-006856-b1w25ob5 1543 4 ( ( -LRB- cord-006856-b1w25ob5 1543 5 one one CD cord-006856-b1w25ob5 1543 6 AIN AIN NNP cord-006856-b1w25ob5 1543 7 III III NNP cord-006856-b1w25ob5 1543 8 ° ° NNS cord-006856-b1w25ob5 1543 9 , , , cord-006856-b1w25ob5 1543 10 two two CD cord-006856-b1w25ob5 1543 11 anal anal JJ cord-006856-b1w25ob5 1543 12 cancers cancer NNS cord-006856-b1w25ob5 1543 13 , , , cord-006856-b1w25ob5 1543 14 pT1 pT1 NNP cord-006856-b1w25ob5 1543 15 and and CC cord-006856-b1w25ob5 1543 16 pT2 pt2 XX cord-006856-b1w25ob5 1543 17 ; ; : cord-006856-b1w25ob5 1543 18 median median NN cord-006856-b1w25ob5 1543 19 age age NN cord-006856-b1w25ob5 1543 20 at at IN cord-006856-b1w25ob5 1543 21 diagnosis diagnosis NN cord-006856-b1w25ob5 1543 22 , , , cord-006856-b1w25ob5 1543 23 50 50 CD cord-006856-b1w25ob5 1543 24 years year NNS cord-006856-b1w25ob5 1543 25 ) ) -RRB- cord-006856-b1w25ob5 1543 26 developed develop VBD cord-006856-b1w25ob5 1543 27 on on IN cord-006856-b1w25ob5 1543 28 average average JJ cord-006856-b1w25ob5 1543 29 7.2 7.2 CD cord-006856-b1w25ob5 1543 30 years year NNS cord-006856-b1w25ob5 1543 31 after after IN cord-006856-b1w25ob5 1543 32 transplantation transplantation NN cord-006856-b1w25ob5 1543 33 ( ( -LRB- cord-006856-b1w25ob5 1543 34 0.08 0.08 CD cord-006856-b1w25ob5 1543 35 % % NN cord-006856-b1w25ob5 1543 36 vs. vs. CC cord-006856-b1w25ob5 1543 37 0.001 0.001 CD cord-006856-b1w25ob5 1543 38 % % NN cord-006856-b1w25ob5 1543 39 in in IN cord-006856-b1w25ob5 1543 40 the the DT cord-006856-b1w25ob5 1543 41 general general JJ cord-006856-b1w25ob5 1543 42 population population NN cord-006856-b1w25ob5 1543 43 ) ) -RRB- cord-006856-b1w25ob5 1543 44 with with IN cord-006856-b1w25ob5 1543 45 a a DT cord-006856-b1w25ob5 1543 46 100 100 CD cord-006856-b1w25ob5 1543 47 % % NN cord-006856-b1w25ob5 1543 48 1-year 1-year CD cord-006856-b1w25ob5 1543 49 survival survival NN cord-006856-b1w25ob5 1543 50 rate rate NN cord-006856-b1w25ob5 1543 51 . . . cord-006856-b1w25ob5 1544 1 All all DT cord-006856-b1w25ob5 1544 2 patients patient NNS cord-006856-b1w25ob5 1544 3 were be VBD cord-006856-b1w25ob5 1544 4 switched switch VBN cord-006856-b1w25ob5 1544 5 to to IN cord-006856-b1w25ob5 1544 6 rapamycin rapamycin NN cord-006856-b1w25ob5 1544 7 or or CC cord-006856-b1w25ob5 1544 8 everolimus everolimus NN cord-006856-b1w25ob5 1544 9 after after IN cord-006856-b1w25ob5 1544 10 completion completion NN cord-006856-b1w25ob5 1544 11 of of IN cord-006856-b1w25ob5 1544 12 primary primary JJ cord-006856-b1w25ob5 1544 13 therapy therapy NN cord-006856-b1w25ob5 1544 14 . . . cord-006856-b1w25ob5 1545 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1545 2 . . . cord-006856-b1w25ob5 1546 1 The the DT cord-006856-b1w25ob5 1546 2 incidence incidence NN cord-006856-b1w25ob5 1546 3 of of IN cord-006856-b1w25ob5 1546 4 anal anal JJ cord-006856-b1w25ob5 1546 5 but but CC cord-006856-b1w25ob5 1546 6 not not RB cord-006856-b1w25ob5 1546 7 of of IN cord-006856-b1w25ob5 1546 8 colorectal colorectal JJ cord-006856-b1w25ob5 1546 9 cancers cancer NNS cord-006856-b1w25ob5 1546 10 in in IN cord-006856-b1w25ob5 1546 11 our -PRON- PRP$ cord-006856-b1w25ob5 1546 12 transplant transplant NN cord-006856-b1w25ob5 1546 13 patient patient NN cord-006856-b1w25ob5 1546 14 population population NN cord-006856-b1w25ob5 1546 15 differed differ VBD cord-006856-b1w25ob5 1546 16 from from IN cord-006856-b1w25ob5 1546 17 that that DT cord-006856-b1w25ob5 1546 18 of of IN cord-006856-b1w25ob5 1546 19 immunocompetent immunocompetent JJ cord-006856-b1w25ob5 1546 20 patients patient NNS cord-006856-b1w25ob5 1546 21 of of IN cord-006856-b1w25ob5 1546 22 corresponding correspond VBG cord-006856-b1w25ob5 1546 23 age age NN cord-006856-b1w25ob5 1546 24 ( ( -LRB- cord-006856-b1w25ob5 1546 25 0.08 0.08 CD cord-006856-b1w25ob5 1546 26 % % NN cord-006856-b1w25ob5 1546 27 vs. vs. CC cord-006856-b1w25ob5 1546 28 0.001 0.001 CD cord-006856-b1w25ob5 1546 29 % % NN cord-006856-b1w25ob5 1546 30 and and CC cord-006856-b1w25ob5 1546 31 0.25 0.25 CD cord-006856-b1w25ob5 1546 32 % % NN cord-006856-b1w25ob5 1546 33 vs. vs. CC cord-006856-b1w25ob5 1546 34 0.2 0.2 CD cord-006856-b1w25ob5 1546 35 % % NN cord-006856-b1w25ob5 1546 36 Tyrol Tyrol NNP cord-006856-b1w25ob5 1546 37 tumor tumor NN cord-006856-b1w25ob5 1546 38 registry registry NN cord-006856-b1w25ob5 1546 39 and and CC cord-006856-b1w25ob5 1546 40 0.3 0.3 CD cord-006856-b1w25ob5 1546 41 % % NN cord-006856-b1w25ob5 1546 42 SEER SEER NNP cord-006856-b1w25ob5 1546 43 ) ) -RRB- cord-006856-b1w25ob5 1546 44 . . . cord-006856-b1w25ob5 1547 1 The the DT cord-006856-b1w25ob5 1547 2 1-year 1-year CD cord-006856-b1w25ob5 1547 3 survival survival NN cord-006856-b1w25ob5 1547 4 rate rate NN cord-006856-b1w25ob5 1547 5 was be VBD cord-006856-b1w25ob5 1547 6 significantly significantly RB cord-006856-b1w25ob5 1547 7 decreased decrease VBN cord-006856-b1w25ob5 1547 8 in in IN cord-006856-b1w25ob5 1547 9 the the DT cord-006856-b1w25ob5 1547 10 transplant transplant NN cord-006856-b1w25ob5 1547 11 group group NN cord-006856-b1w25ob5 1547 12 with with IN cord-006856-b1w25ob5 1547 13 T3 T3 NNP cord-006856-b1w25ob5 1547 14 tumors tumor NNS cord-006856-b1w25ob5 1547 15 ( ( -LRB- cord-006856-b1w25ob5 1547 16 67 67 CD cord-006856-b1w25ob5 1547 17 % % NN cord-006856-b1w25ob5 1547 18 [ [ -LRB- cord-006856-b1w25ob5 1547 19 rectum rectum NN cord-006856-b1w25ob5 1547 20 ] ] -RRB- cord-006856-b1w25ob5 1547 21 and and CC cord-006856-b1w25ob5 1547 22 50 50 CD cord-006856-b1w25ob5 1547 23 % % NN cord-006856-b1w25ob5 1547 24 [ [ -LRB- cord-006856-b1w25ob5 1547 25 colon colon NN cord-006856-b1w25ob5 1547 26 ] ] -RRB- cord-006856-b1w25ob5 1547 27 vs. vs. NN cord-006856-b1w25ob5 1547 28 80 80 CD cord-006856-b1w25ob5 1547 29 % % NN cord-006856-b1w25ob5 1547 30 ) ) -RRB- cord-006856-b1w25ob5 1547 31 . . . cord-006856-b1w25ob5 1548 1 Potential potential JJ cord-006856-b1w25ob5 1548 2 antineoplastic antineoplastic JJ cord-006856-b1w25ob5 1548 3 effects effect NNS cord-006856-b1w25ob5 1548 4 of of IN cord-006856-b1w25ob5 1548 5 rapamycin rapamycin NNS cord-006856-b1w25ob5 1548 6 and and CC cord-006856-b1w25ob5 1548 7 overall overall RB cord-006856-b1w25ob5 1548 8 less less JJR cord-006856-b1w25ob5 1548 9 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1548 10 long long JJ cord-006856-b1w25ob5 1548 11 - - HYPH cord-006856-b1w25ob5 1548 12 term term NN cord-006856-b1w25ob5 1548 13 may may MD cord-006856-b1w25ob5 1548 14 improve improve VB cord-006856-b1w25ob5 1548 15 prognosis prognosis NN cord-006856-b1w25ob5 1548 16 of of IN cord-006856-b1w25ob5 1548 17 colorectal colorectal JJ cord-006856-b1w25ob5 1548 18 malignancies malignancy NNS cord-006856-b1w25ob5 1548 19 following follow VBG cord-006856-b1w25ob5 1548 20 transplantation transplantation NN cord-006856-b1w25ob5 1548 21 . . . cord-006856-b1w25ob5 1549 1 Background background NN cord-006856-b1w25ob5 1549 2 . . . cord-006856-b1w25ob5 1550 1 Solid solid JJ cord-006856-b1w25ob5 1550 2 - - HYPH cord-006856-b1w25ob5 1550 3 organ organ NN cord-006856-b1w25ob5 1550 4 transplantation transplantation NN cord-006856-b1w25ob5 1550 5 is be VBZ cord-006856-b1w25ob5 1550 6 the the DT cord-006856-b1w25ob5 1550 7 treatment treatment NN cord-006856-b1w25ob5 1550 8 of of IN cord-006856-b1w25ob5 1550 9 choice choice NN cord-006856-b1w25ob5 1550 10 for for IN cord-006856-b1w25ob5 1550 11 terminal terminal JJ cord-006856-b1w25ob5 1550 12 organ organ NN cord-006856-b1w25ob5 1550 13 failure failure NN cord-006856-b1w25ob5 1550 14 . . . cord-006856-b1w25ob5 1551 1 Due due IN cord-006856-b1w25ob5 1551 2 to to IN cord-006856-b1w25ob5 1551 3 the the DT cord-006856-b1w25ob5 1551 4 scarcity scarcity NN cord-006856-b1w25ob5 1551 5 of of IN cord-006856-b1w25ob5 1551 6 organs organ NNS cord-006856-b1w25ob5 1551 7 , , , cord-006856-b1w25ob5 1551 8 the the DT cord-006856-b1w25ob5 1551 9 mandate mandate NN cord-006856-b1w25ob5 1551 10 to to TO cord-006856-b1w25ob5 1551 11 utilize utilize VB cord-006856-b1w25ob5 1551 12 extended extend VBN cord-006856-b1w25ob5 1551 13 - - HYPH cord-006856-b1w25ob5 1551 14 criteria criterion NNS cord-006856-b1w25ob5 1551 15 donors donor NNS cord-006856-b1w25ob5 1551 16 has have VBZ cord-006856-b1w25ob5 1551 17 dramatically dramatically RB cord-006856-b1w25ob5 1551 18 increased increase VBN cord-006856-b1w25ob5 1551 19 over over IN cord-006856-b1w25ob5 1551 20 time time NN cord-006856-b1w25ob5 1551 21 and and CC cord-006856-b1w25ob5 1551 22 achievable achievable JJ cord-006856-b1w25ob5 1551 23 results result NNS cord-006856-b1w25ob5 1551 24 are be VBP cord-006856-b1w25ob5 1551 25 good good JJ cord-006856-b1w25ob5 1551 26 . . . cord-006856-b1w25ob5 1552 1 This this DT cord-006856-b1w25ob5 1552 2 harbors harbor VBZ cord-006856-b1w25ob5 1552 3 the the DT cord-006856-b1w25ob5 1552 4 risk risk NN cord-006856-b1w25ob5 1552 5 of of IN cord-006856-b1w25ob5 1552 6 transmission transmission NN cord-006856-b1w25ob5 1552 7 of of IN cord-006856-b1w25ob5 1552 8 infections infection NNS cord-006856-b1w25ob5 1552 9 from from IN cord-006856-b1w25ob5 1552 10 the the DT cord-006856-b1w25ob5 1552 11 donor donor NN cord-006856-b1w25ob5 1552 12 to to IN cord-006856-b1w25ob5 1552 13 the the DT cord-006856-b1w25ob5 1552 14 recipient recipient NN cord-006856-b1w25ob5 1552 15 . . . cord-006856-b1w25ob5 1553 1 Aim aim VB cord-006856-b1w25ob5 1553 2 . . . cord-006856-b1w25ob5 1554 1 An an DT cord-006856-b1w25ob5 1554 2 overview overview NN cord-006856-b1w25ob5 1554 3 on on IN cord-006856-b1w25ob5 1554 4 the the DT cord-006856-b1w25ob5 1554 5 magnitude magnitude NN cord-006856-b1w25ob5 1554 6 of of IN cord-006856-b1w25ob5 1554 7 possible possible JJ cord-006856-b1w25ob5 1554 8 transmittable transmittable JJ cord-006856-b1w25ob5 1554 9 diseases disease NNS cord-006856-b1w25ob5 1554 10 that that WDT cord-006856-b1w25ob5 1554 11 could could MD cord-006856-b1w25ob5 1554 12 accompany accompany VB cord-006856-b1w25ob5 1554 13 donor donor NN cord-006856-b1w25ob5 1554 14 organs organ NNS cord-006856-b1w25ob5 1554 15 is be VBZ cord-006856-b1w25ob5 1554 16 given give VBN cord-006856-b1w25ob5 1554 17 . . . cord-006856-b1w25ob5 1555 1 Possible possible JJ cord-006856-b1w25ob5 1555 2 preventive preventive JJ cord-006856-b1w25ob5 1555 3 strategies strategy NNS cord-006856-b1w25ob5 1555 4 are be VBP cord-006856-b1w25ob5 1555 5 discussed discuss VBN cord-006856-b1w25ob5 1555 6 . . . cord-006856-b1w25ob5 1556 1 Overview overview NN cord-006856-b1w25ob5 1556 2 . . . cord-006856-b1w25ob5 1557 1 The the DT cord-006856-b1w25ob5 1557 2 faith faith NN cord-006856-b1w25ob5 1557 3 of of IN cord-006856-b1w25ob5 1557 4 an an DT cord-006856-b1w25ob5 1557 5 organism organism NN cord-006856-b1w25ob5 1557 6 that that WDT cord-006856-b1w25ob5 1557 7 is be VBZ cord-006856-b1w25ob5 1557 8 transmitted transmit VBN cord-006856-b1w25ob5 1557 9 by by IN cord-006856-b1w25ob5 1557 10 a a DT cord-006856-b1w25ob5 1557 11 donor donor NN cord-006856-b1w25ob5 1557 12 allograft allograft NN cord-006856-b1w25ob5 1557 13 depends depend VBZ cord-006856-b1w25ob5 1557 14 on on IN cord-006856-b1w25ob5 1557 15 the the DT cord-006856-b1w25ob5 1557 16 virulence virulence NN cord-006856-b1w25ob5 1557 17 and and CC cord-006856-b1w25ob5 1557 18 the the DT cord-006856-b1w25ob5 1557 19 quantity quantity NN cord-006856-b1w25ob5 1557 20 of of IN cord-006856-b1w25ob5 1557 21 the the DT cord-006856-b1w25ob5 1557 22 transmitted transmit VBN cord-006856-b1w25ob5 1557 23 pathogen pathogen NN cord-006856-b1w25ob5 1557 24 and and CC cord-006856-b1w25ob5 1557 25 the the DT cord-006856-b1w25ob5 1557 26 site site NN cord-006856-b1w25ob5 1557 27 of of IN cord-006856-b1w25ob5 1557 28 infection infection NN cord-006856-b1w25ob5 1557 29 and and CC cord-006856-b1w25ob5 1557 30 furthermore furthermore RB cord-006856-b1w25ob5 1557 31 is be VBZ cord-006856-b1w25ob5 1557 32 impacted impact VBN cord-006856-b1w25ob5 1557 33 by by IN cord-006856-b1w25ob5 1557 34 prophylactic prophylactic JJ cord-006856-b1w25ob5 1557 35 steps step NNS cord-006856-b1w25ob5 1557 36 undertaken undertake VBN cord-006856-b1w25ob5 1557 37 during during IN cord-006856-b1w25ob5 1557 38 donor donor NN cord-006856-b1w25ob5 1557 39 procurement procurement NN cord-006856-b1w25ob5 1557 40 , , , cord-006856-b1w25ob5 1557 41 organ organ NN cord-006856-b1w25ob5 1557 42 perfusion perfusion NN cord-006856-b1w25ob5 1557 43 , , , cord-006856-b1w25ob5 1557 44 implantation implantation NN cord-006856-b1w25ob5 1557 45 , , , cord-006856-b1w25ob5 1557 46 and and CC cord-006856-b1w25ob5 1557 47 post post NN cord-006856-b1w25ob5 1557 48 transplant transplant NN cord-006856-b1w25ob5 1557 49 course course NN cord-006856-b1w25ob5 1557 50 and and CC cord-006856-b1w25ob5 1557 51 lastly lastly RB cord-006856-b1w25ob5 1557 52 depends depend VBZ cord-006856-b1w25ob5 1557 53 on on IN cord-006856-b1w25ob5 1557 54 the the DT cord-006856-b1w25ob5 1557 55 ability ability NN cord-006856-b1w25ob5 1557 56 of of IN cord-006856-b1w25ob5 1557 57 the the DT cord-006856-b1w25ob5 1557 58 recipient recipient NN cord-006856-b1w25ob5 1557 59 to to TO cord-006856-b1w25ob5 1557 60 control control VB cord-006856-b1w25ob5 1557 61 the the DT cord-006856-b1w25ob5 1557 62 infection infection NN cord-006856-b1w25ob5 1557 63 by by IN cord-006856-b1w25ob5 1557 64 the the DT cord-006856-b1w25ob5 1557 65 immune immune JJ cord-006856-b1w25ob5 1557 66 system system NN cord-006856-b1w25ob5 1557 67 . . . cord-006856-b1w25ob5 1558 1 In in IN cord-006856-b1w25ob5 1558 2 the the DT cord-006856-b1w25ob5 1558 3 best good JJS cord-006856-b1w25ob5 1558 4 case case NN cord-006856-b1w25ob5 1558 5 , , , cord-006856-b1w25ob5 1558 6 the the DT cord-006856-b1w25ob5 1558 7 microorganism microorganism NN cord-006856-b1w25ob5 1558 8 is be VBZ cord-006856-b1w25ob5 1558 9 cleared clear VBN cord-006856-b1w25ob5 1558 10 before before IN cord-006856-b1w25ob5 1558 11 it -PRON- PRP cord-006856-b1w25ob5 1558 12 can can MD cord-006856-b1w25ob5 1558 13 do do VB cord-006856-b1w25ob5 1558 14 any any DT cord-006856-b1w25ob5 1558 15 harm harm NN cord-006856-b1w25ob5 1558 16 ; ; : cord-006856-b1w25ob5 1558 17 however however RB cord-006856-b1w25ob5 1558 18 , , , cord-006856-b1w25ob5 1558 19 in in IN cord-006856-b1w25ob5 1558 20 the the DT cord-006856-b1w25ob5 1558 21 worst bad JJS cord-006856-b1w25ob5 1558 22 case case NN cord-006856-b1w25ob5 1558 23 scenario scenario NN cord-006856-b1w25ob5 1558 24 , , , cord-006856-b1w25ob5 1558 25 transmitted transmit VBN cord-006856-b1w25ob5 1558 26 pathogens pathogen NNS cord-006856-b1w25ob5 1558 27 can can MD cord-006856-b1w25ob5 1558 28 lead lead VB cord-006856-b1w25ob5 1558 29 to to IN cord-006856-b1w25ob5 1558 30 fatality fatality NN cord-006856-b1w25ob5 1558 31 . . . cord-006856-b1w25ob5 1559 1 There there EX cord-006856-b1w25ob5 1559 2 is be VBZ cord-006856-b1w25ob5 1559 3 a a DT cord-006856-b1w25ob5 1559 4 multitude multitude NN cord-006856-b1w25ob5 1559 5 of of IN cord-006856-b1w25ob5 1559 6 pathogens pathogen NNS cord-006856-b1w25ob5 1559 7 that that WDT cord-006856-b1w25ob5 1559 8 can can MD cord-006856-b1w25ob5 1559 9 potentially potentially RB cord-006856-b1w25ob5 1559 10 be be VB cord-006856-b1w25ob5 1559 11 transmitted transmit VBN cord-006856-b1w25ob5 1559 12 by by IN cord-006856-b1w25ob5 1559 13 an an DT cord-006856-b1w25ob5 1559 14 allograft allograft NN cord-006856-b1w25ob5 1559 15 including include VBG cord-006856-b1w25ob5 1559 16 viruses virus NNS cord-006856-b1w25ob5 1559 17 , , , cord-006856-b1w25ob5 1559 18 bacteria bacteria NNS cord-006856-b1w25ob5 1559 19 , , , cord-006856-b1w25ob5 1559 20 fungi fungus NNS cord-006856-b1w25ob5 1559 21 , , , cord-006856-b1w25ob5 1559 22 and and CC cord-006856-b1w25ob5 1559 23 protozoa protozoan NNS cord-006856-b1w25ob5 1559 24 . . . cord-006856-b1w25ob5 1560 1 There there EX cord-006856-b1w25ob5 1560 2 are be VBP cord-006856-b1w25ob5 1560 3 microorganisms microorganism NNS cord-006856-b1w25ob5 1560 4 that that WDT cord-006856-b1w25ob5 1560 5 can can MD cord-006856-b1w25ob5 1560 6 be be VB cord-006856-b1w25ob5 1560 7 transmitted transmit VBN cord-006856-b1w25ob5 1560 8 by by IN cord-006856-b1w25ob5 1560 9 any any DT cord-006856-b1w25ob5 1560 10 type type NN cord-006856-b1w25ob5 1560 11 of of IN cord-006856-b1w25ob5 1560 12 graft graft NN cord-006856-b1w25ob5 1560 13 and and CC cord-006856-b1w25ob5 1560 14 there there EX cord-006856-b1w25ob5 1560 15 are be VBP cord-006856-b1w25ob5 1561 1 pathogens pathogen NNS cord-006856-b1w25ob5 1561 2 which which WDT cord-006856-b1w25ob5 1561 3 due due JJ cord-006856-b1w25ob5 1561 4 to to IN cord-006856-b1w25ob5 1561 5 a a DT cord-006856-b1w25ob5 1561 6 certain certain JJ cord-006856-b1w25ob5 1561 7 tropism tropism NN cord-006856-b1w25ob5 1561 8 can can MD cord-006856-b1w25ob5 1561 9 be be VB cord-006856-b1w25ob5 1561 10 transmitted transmit VBN cord-006856-b1w25ob5 1561 11 by by IN cord-006856-b1w25ob5 1561 12 certain certain JJ cord-006856-b1w25ob5 1561 13 organs organ NNS cord-006856-b1w25ob5 1561 14 only only RB cord-006856-b1w25ob5 1561 15 . . . cord-006856-b1w25ob5 1562 1 There there EX cord-006856-b1w25ob5 1562 2 are be VBP cord-006856-b1w25ob5 1562 3 common common JJ cord-006856-b1w25ob5 1562 4 pathogens pathogen NNS cord-006856-b1w25ob5 1562 5 such such JJ cord-006856-b1w25ob5 1562 6 as as IN cord-006856-b1w25ob5 1562 7 CMV CMV NNP cord-006856-b1w25ob5 1562 8 and and CC cord-006856-b1w25ob5 1562 9 EBV EBV NNP cord-006856-b1w25ob5 1562 10 as as IN cord-006856-b1w25ob5 1562 11 opposed oppose VBN cord-006856-b1w25ob5 1562 12 to to IN cord-006856-b1w25ob5 1562 13 extremely extremely RB cord-006856-b1w25ob5 1562 14 rare rare JJ cord-006856-b1w25ob5 1562 15 pathogens pathogen NNS cord-006856-b1w25ob5 1562 16 such such JJ cord-006856-b1w25ob5 1562 17 as as IN cord-006856-b1w25ob5 1562 18 Lyssa Lyssa NNP cord-006856-b1w25ob5 1562 19 , , , cord-006856-b1w25ob5 1562 20 West West NNP cord-006856-b1w25ob5 1562 21 Nile Nile NNP cord-006856-b1w25ob5 1562 22 fever fever NN cord-006856-b1w25ob5 1562 23 , , , cord-006856-b1w25ob5 1562 24 or or CC cord-006856-b1w25ob5 1562 25 lymphochoriomenigitis lymphochoriomenigitis NNP cord-006856-b1w25ob5 1562 26 virus virus NN cord-006856-b1w25ob5 1562 27 . . . cord-006856-b1w25ob5 1563 1 Intracellular Intracellular NNP cord-006856-b1w25ob5 1563 2 pathogens pathogen NNS cord-006856-b1w25ob5 1563 3 are be VBP cord-006856-b1w25ob5 1563 4 preferably preferably RB cord-006856-b1w25ob5 1563 5 targeted target VBN cord-006856-b1w25ob5 1563 6 by by IN cord-006856-b1w25ob5 1564 1 MHC MHC NNP cord-006856-b1w25ob5 1564 2 restricted restrict VBD cord-006856-b1w25ob5 1564 3 cytotoxic cytotoxic JJ cord-006856-b1w25ob5 1564 4 T t NN cord-006856-b1w25ob5 1564 5 - - HYPH cord-006856-b1w25ob5 1564 6 cell cell NN cord-006856-b1w25ob5 1564 7 reaction reaction NN cord-006856-b1w25ob5 1564 8 . . . cord-006856-b1w25ob5 1565 1 As as IN cord-006856-b1w25ob5 1565 2 in in IN cord-006856-b1w25ob5 1565 3 organ organ NN cord-006856-b1w25ob5 1565 4 transplantation transplantation NN cord-006856-b1w25ob5 1565 5 HLA HLA NNP cord-006856-b1w25ob5 1565 6 matching matching NN cord-006856-b1w25ob5 1565 7 is be VBZ cord-006856-b1w25ob5 1565 8 in in IN cord-006856-b1w25ob5 1565 9 general general JJ cord-006856-b1w25ob5 1565 10 not not RB cord-006856-b1w25ob5 1565 11 performed perform VBN cord-006856-b1w25ob5 1565 12 , , , cord-006856-b1w25ob5 1565 13 donor donor NN cord-006856-b1w25ob5 1565 14 - - HYPH cord-006856-b1w25ob5 1565 15 derived derive VBN cord-006856-b1w25ob5 1565 16 antigen antigen NN cord-006856-b1w25ob5 1565 17 - - HYPH cord-006856-b1w25ob5 1565 18 presenting present VBG cord-006856-b1w25ob5 1565 19 cells cell NNS cord-006856-b1w25ob5 1565 20 can can MD cord-006856-b1w25ob5 1565 21 not not RB cord-006856-b1w25ob5 1565 22 be be VB cord-006856-b1w25ob5 1565 23 recognised recognise VBN cord-006856-b1w25ob5 1565 24 by by IN cord-006856-b1w25ob5 1565 25 recipient recipient NN cord-006856-b1w25ob5 1565 26 - - HYPH cord-006856-b1w25ob5 1565 27 specific specific JJ cord-006856-b1w25ob5 1565 28 CD8 CD8 NNP cord-006856-b1w25ob5 1565 29 + + CC cord-006856-b1w25ob5 1565 30 lymphocytes lymphocyte NNS cord-006856-b1w25ob5 1565 31 . . . cord-006856-b1w25ob5 1566 1 Therefore therefore RB cord-006856-b1w25ob5 1566 2 , , , cord-006856-b1w25ob5 1566 3 either either CC cord-006856-b1w25ob5 1566 4 donor donor NN cord-006856-b1w25ob5 1566 5 - - HYPH cord-006856-b1w25ob5 1566 6 specific specific JJ cord-006856-b1w25ob5 1566 7 cytotoxic cytotoxic JJ cord-006856-b1w25ob5 1566 8 T t NN cord-006856-b1w25ob5 1566 9 cells cell NNS cord-006856-b1w25ob5 1566 10 must must MD cord-006856-b1w25ob5 1566 11 function function VB cord-006856-b1w25ob5 1566 12 as as IN cord-006856-b1w25ob5 1566 13 counterparts counterpart NNS cord-006856-b1w25ob5 1566 14 or or CC cord-006856-b1w25ob5 1566 15 alternative alternative JJ cord-006856-b1w25ob5 1566 16 tar tar NN cord-006856-b1w25ob5 1566 17 - - HYPH cord-006856-b1w25ob5 1566 18 gets get NNS cord-006856-b1w25ob5 1566 19 must must MD cord-006856-b1w25ob5 1566 20 be be VB cord-006856-b1w25ob5 1566 21 defined define VBN cord-006856-b1w25ob5 1566 22 by by IN cord-006856-b1w25ob5 1566 23 the the DT cord-006856-b1w25ob5 1566 24 immune immune JJ cord-006856-b1w25ob5 1566 25 system system NN cord-006856-b1w25ob5 1566 26 . . . cord-006856-b1w25ob5 1567 1 Bacterial bacterial JJ cord-006856-b1w25ob5 1567 2 and/or and/or CC cord-006856-b1w25ob5 1567 3 fungal fungal JJ cord-006856-b1w25ob5 1567 4 contamination contamination NN cord-006856-b1w25ob5 1567 5 must must MD cord-006856-b1w25ob5 1567 6 be be VB cord-006856-b1w25ob5 1567 7 considered consider VBN cord-006856-b1w25ob5 1567 8 in in IN cord-006856-b1w25ob5 1567 9 lung lung NN cord-006856-b1w25ob5 1567 10 transplantation transplantation NN cord-006856-b1w25ob5 1567 11 ( ( -LRB- cord-006856-b1w25ob5 1567 12 bronchial bronchial JJ cord-006856-b1w25ob5 1567 13 stump stump NN cord-006856-b1w25ob5 1567 14 ) ) -RRB- cord-006856-b1w25ob5 1567 15 , , , cord-006856-b1w25ob5 1567 16 pancreas pancreas NN cord-006856-b1w25ob5 1567 17 transplantation transplantation NN cord-006856-b1w25ob5 1567 18 ( ( -LRB- cord-006856-b1w25ob5 1567 19 duodenal duodenal JJ cord-006856-b1w25ob5 1567 20 segment segment NN cord-006856-b1w25ob5 1567 21 ) ) -RRB- cord-006856-b1w25ob5 1567 22 , , , cord-006856-b1w25ob5 1567 23 and and CC cord-006856-b1w25ob5 1567 24 small small JJ cord-006856-b1w25ob5 1567 25 bowel bowel NN cord-006856-b1w25ob5 1567 26 allografts allograft NNS cord-006856-b1w25ob5 1567 27 . . . cord-006856-b1w25ob5 1568 1 Cardiac cardiac JJ cord-006856-b1w25ob5 1568 2 , , , cord-006856-b1w25ob5 1568 3 renal renal JJ cord-006856-b1w25ob5 1568 4 , , , cord-006856-b1w25ob5 1568 5 and and CC cord-006856-b1w25ob5 1568 6 liver liver NN cord-006856-b1w25ob5 1568 7 grafts graft NNS cord-006856-b1w25ob5 1568 8 can can MD cord-006856-b1w25ob5 1568 9 be be VB cord-006856-b1w25ob5 1568 10 considered consider VBN cord-006856-b1w25ob5 1568 11 sterile sterile JJ cord-006856-b1w25ob5 1568 12 but but CC cord-006856-b1w25ob5 1568 13 can can MD cord-006856-b1w25ob5 1568 14 become become VB cord-006856-b1w25ob5 1568 15 contaminated contaminate VBN cord-006856-b1w25ob5 1568 16 during during IN cord-006856-b1w25ob5 1568 17 procurement procurement NN cord-006856-b1w25ob5 1568 18 . . . cord-006856-b1w25ob5 1569 1 Rare rare JJ cord-006856-b1w25ob5 1569 2 transmitted transmit VBN cord-006856-b1w25ob5 1569 3 organisms organism NNS cord-006856-b1w25ob5 1569 4 are be VBP cord-006856-b1w25ob5 1569 5 Toxoplasma toxoplasma JJ cord-006856-b1w25ob5 1569 6 gondii gondii NN cord-006856-b1w25ob5 1569 7 , , , cord-006856-b1w25ob5 1569 8 Trypanosoma Trypanosoma NNP cord-006856-b1w25ob5 1569 9 cruzii cruzii NN cord-006856-b1w25ob5 1569 10 , , , cord-006856-b1w25ob5 1569 11 and and CC cord-006856-b1w25ob5 1569 12 Schistosoma Schistosoma NNP cord-006856-b1w25ob5 1569 13 mansoni mansoni NNP cord-006856-b1w25ob5 1569 14 . . . cord-006856-b1w25ob5 1570 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1570 2 . . . cord-006856-b1w25ob5 1571 1 When when WRB cord-006856-b1w25ob5 1571 2 looking look VBG cord-006856-b1w25ob5 1571 3 at at IN cord-006856-b1w25ob5 1571 4 allocation allocation NN cord-006856-b1w25ob5 1571 5 of of IN cord-006856-b1w25ob5 1571 6 latently latently RB cord-006856-b1w25ob5 1571 7 virus virus NN cord-006856-b1w25ob5 1571 8 - - HYPH cord-006856-b1w25ob5 1571 9 infected infect VBN cord-006856-b1w25ob5 1571 10 organs organ NNS cord-006856-b1w25ob5 1571 11 , , , cord-006856-b1w25ob5 1571 12 they -PRON- PRP cord-006856-b1w25ob5 1571 13 should should MD cord-006856-b1w25ob5 1571 14 be be VB cord-006856-b1w25ob5 1571 15 preferably preferably RB cord-006856-b1w25ob5 1571 16 given give VBN cord-006856-b1w25ob5 1571 17 to to IN cord-006856-b1w25ob5 1571 18 recipients recipient NNS cord-006856-b1w25ob5 1571 19 who who WP cord-006856-b1w25ob5 1571 20 have have VBP cord-006856-b1w25ob5 1571 21 antibodies antibody NNS cord-006856-b1w25ob5 1571 22 against against IN cord-006856-b1w25ob5 1571 23 the the DT cord-006856-b1w25ob5 1571 24 particular particular JJ cord-006856-b1w25ob5 1571 25 agent agent NN cord-006856-b1w25ob5 1571 26 . . . cord-006856-b1w25ob5 1572 1 In in IN cord-006856-b1w25ob5 1572 2 terms term NNS cord-006856-b1w25ob5 1572 3 of of IN cord-006856-b1w25ob5 1572 4 bacterial bacterial JJ cord-006856-b1w25ob5 1572 5 or or CC cord-006856-b1w25ob5 1572 6 fungal fungal JJ cord-006856-b1w25ob5 1572 7 contamination contamination NN cord-006856-b1w25ob5 1572 8 of of IN cord-006856-b1w25ob5 1572 9 graft graft NN cord-006856-b1w25ob5 1572 10 and/or and/or CC cord-006856-b1w25ob5 1572 11 preservation preservation NN cord-006856-b1w25ob5 1572 12 solution solution NN cord-006856-b1w25ob5 1572 13 , , , cord-006856-b1w25ob5 1572 14 routine routine JJ cord-006856-b1w25ob5 1572 15 monitoring monitoring NN cord-006856-b1w25ob5 1572 16 seems seem VBZ cord-006856-b1w25ob5 1572 17 mandatory mandatory JJ cord-006856-b1w25ob5 1572 18 in in IN cord-006856-b1w25ob5 1572 19 order order NN cord-006856-b1w25ob5 1572 20 to to TO cord-006856-b1w25ob5 1572 21 assure assure VB cord-006856-b1w25ob5 1572 22 quality quality NN cord-006856-b1w25ob5 1572 23 . . . cord-006856-b1w25ob5 1573 1 Keeping keep VBG cord-006856-b1w25ob5 1573 2 blood blood NN cord-006856-b1w25ob5 1573 3 and and CC cord-006856-b1w25ob5 1573 4 serum serum NN cord-006856-b1w25ob5 1573 5 samples sample NNS cord-006856-b1w25ob5 1573 6 from from IN cord-006856-b1w25ob5 1573 7 donors donor NNS cord-006856-b1w25ob5 1573 8 should should MD cord-006856-b1w25ob5 1573 9 be be VB cord-006856-b1w25ob5 1573 10 carried carry VBN cord-006856-b1w25ob5 1573 11 out out RP cord-006856-b1w25ob5 1573 12 from from IN cord-006856-b1w25ob5 1573 13 an an DT cord-006856-b1w25ob5 1573 14 epidemiological epidemiological JJ cord-006856-b1w25ob5 1573 15 and and CC cord-006856-b1w25ob5 1573 16 legal legal JJ cord-006856-b1w25ob5 1573 17 standpoint standpoint NN cord-006856-b1w25ob5 1573 18 . . . cord-006856-b1w25ob5 1574 1 Bacterial bacterial JJ cord-006856-b1w25ob5 1574 2 and and CC cord-006856-b1w25ob5 1574 3 fungal fungal JJ cord-006856-b1w25ob5 1574 4 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1574 5 should should MD cord-006856-b1w25ob5 1574 6 be be VB cord-006856-b1w25ob5 1574 7 used use VBN cord-006856-b1w25ob5 1574 8 to to TO cord-006856-b1w25ob5 1574 9 prevent prevent VB cord-006856-b1w25ob5 1574 10 not not RB cord-006856-b1w25ob5 1574 11 only only RB cord-006856-b1w25ob5 1574 12 recipient recipient NN cord-006856-b1w25ob5 1574 13 - - : cord-006856-b1w25ob5 1574 14 but but CC cord-006856-b1w25ob5 1574 15 also also RB cord-006856-b1w25ob5 1574 16 donor donor NN cord-006856-b1w25ob5 1574 17 - - HYPH cord-006856-b1w25ob5 1574 18 derived derive VBN cord-006856-b1w25ob5 1574 19 pathogens pathogen NNS cord-006856-b1w25ob5 1574 20 . . . cord-006856-b1w25ob5 1575 1 Antiviral antiviral JJ cord-006856-b1w25ob5 1575 2 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1575 3 is be VBZ cord-006856-b1w25ob5 1575 4 standard standard JJ cord-006856-b1w25ob5 1575 5 for for IN cord-006856-b1w25ob5 1575 6 CMV CMV NNP cord-006856-b1w25ob5 1575 7 and and CC cord-006856-b1w25ob5 1575 8 HBV HBV NNP cord-006856-b1w25ob5 1575 9 , , , cord-006856-b1w25ob5 1575 10 for for IN cord-006856-b1w25ob5 1575 11 all all DT cord-006856-b1w25ob5 1575 12 other other JJ cord-006856-b1w25ob5 1575 13 viruses virus NNS cord-006856-b1w25ob5 1575 14 no no DT cord-006856-b1w25ob5 1575 15 final final JJ cord-006856-b1w25ob5 1575 16 recommendations recommendation NNS cord-006856-b1w25ob5 1575 17 are be VBP cord-006856-b1w25ob5 1575 18 available available JJ cord-006856-b1w25ob5 1575 19 . . . cord-006856-b1w25ob5 1576 1 Methods method NNS cord-006856-b1w25ob5 1576 2 . . . cord-006856-b1w25ob5 1577 1 The the DT cord-006856-b1w25ob5 1577 2 aim aim NN cord-006856-b1w25ob5 1577 3 of of IN cord-006856-b1w25ob5 1577 4 the the DT cord-006856-b1w25ob5 1577 5 current current JJ cord-006856-b1w25ob5 1577 6 review review NN cord-006856-b1w25ob5 1577 7 was be VBD cord-006856-b1w25ob5 1577 8 to to TO cord-006856-b1w25ob5 1577 9 investigate investigate VB cord-006856-b1w25ob5 1577 10 the the DT cord-006856-b1w25ob5 1577 11 impact impact NN cord-006856-b1w25ob5 1577 12 of of IN cord-006856-b1w25ob5 1577 13 several several JJ cord-006856-b1w25ob5 1577 14 risk risk NN cord-006856-b1w25ob5 1577 15 factors factor NNS cord-006856-b1w25ob5 1577 16 on on IN cord-006856-b1w25ob5 1577 17 PTLD PTLD NNP cord-006856-b1w25ob5 1577 18 . . . cord-006856-b1w25ob5 1578 1 Therefore therefore RB cord-006856-b1w25ob5 1578 2 , , , cord-006856-b1w25ob5 1578 3 patients patient NNS cord-006856-b1w25ob5 1578 4 developing develop VBG cord-006856-b1w25ob5 1578 5 PTLD PTLD NNP cord-006856-b1w25ob5 1578 6 after after IN cord-006856-b1w25ob5 1578 7 heart heart NN cord-006856-b1w25ob5 1578 8 transplantation transplantation NN cord-006856-b1w25ob5 1578 9 at at IN cord-006856-b1w25ob5 1578 10 our -PRON- PRP$ cord-006856-b1w25ob5 1578 11 institution institution NN cord-006856-b1w25ob5 1578 12 were be VBD cord-006856-b1w25ob5 1578 13 screened screen VBN cord-006856-b1w25ob5 1578 14 . . . cord-006856-b1w25ob5 1579 1 Results result NNS cord-006856-b1w25ob5 1579 2 . . . cord-006856-b1w25ob5 1580 1 8 8 CD cord-006856-b1w25ob5 1580 2 patients patient NNS cord-006856-b1w25ob5 1580 3 have have VBP cord-006856-b1w25ob5 1580 4 been be VBN cord-006856-b1w25ob5 1580 5 identified identify VBN cord-006856-b1w25ob5 1580 6 with with IN cord-006856-b1w25ob5 1580 7 PTLD PTLD NNP cord-006856-b1w25ob5 1580 8 , , , cord-006856-b1w25ob5 1580 9 all all DT cord-006856-b1w25ob5 1580 10 cases case NNS cord-006856-b1w25ob5 1580 11 occurring occur VBG cord-006856-b1w25ob5 1580 12 during during IN cord-006856-b1w25ob5 1580 13 the the DT cord-006856-b1w25ob5 1580 14 last last JJ cord-006856-b1w25ob5 1580 15 decade decade NN cord-006856-b1w25ob5 1580 16 . . . cord-006856-b1w25ob5 1581 1 Mean mean JJ cord-006856-b1w25ob5 1581 2 age age NN cord-006856-b1w25ob5 1581 3 at at IN cord-006856-b1w25ob5 1581 4 PTLD PTLD NNP cord-006856-b1w25ob5 1581 5 onset onset NN cord-006856-b1w25ob5 1581 6 was be VBD cord-006856-b1w25ob5 1581 7 46.4 46.4 CD cord-006856-b1w25ob5 1581 8 ± ± CD cord-006856-b1w25ob5 1581 9 20.0 20.0 CD cord-006856-b1w25ob5 1581 10 years year NNS cord-006856-b1w25ob5 1581 11 and and CC cord-006856-b1w25ob5 1581 12 time time NN cord-006856-b1w25ob5 1581 13 between between IN cord-006856-b1w25ob5 1581 14 transplant transplant NN cord-006856-b1w25ob5 1581 15 and and CC cord-006856-b1w25ob5 1581 16 development development NN cord-006856-b1w25ob5 1581 17 of of IN cord-006856-b1w25ob5 1581 18 PTLD PTLD NNP cord-006856-b1w25ob5 1581 19 was be VBD cord-006856-b1w25ob5 1581 20 26.4 26.4 CD cord-006856-b1w25ob5 1581 21 ± ± NNP cord-006856-b1w25ob5 1581 22 30.4 30.4 CD cord-006856-b1w25ob5 1581 23 months month NNS cord-006856-b1w25ob5 1581 24 . . . cord-006856-b1w25ob5 1582 1 There there EX cord-006856-b1w25ob5 1582 2 were be VBD cord-006856-b1w25ob5 1582 3 5 5 CD cord-006856-b1w25ob5 1582 4 EBV EBV NNP cord-006856-b1w25ob5 1582 5 - - HYPH cord-006856-b1w25ob5 1582 6 associated associate VBN cord-006856-b1w25ob5 1582 7 PTLDs ptld NNS cord-006856-b1w25ob5 1582 8 , , , cord-006856-b1w25ob5 1582 9 2 2 CD cord-006856-b1w25ob5 1582 10 non non JJ cord-006856-b1w25ob5 1582 11 - - JJ cord-006856-b1w25ob5 1582 12 EBV EBV NNP cord-006856-b1w25ob5 1582 13 - - HYPH cord-006856-b1w25ob5 1582 14 associated associate VBN cord-006856-b1w25ob5 1582 15 , , , cord-006856-b1w25ob5 1582 16 CD20-negative CD20-negative NNP cord-006856-b1w25ob5 1582 17 B b NN cord-006856-b1w25ob5 1582 18 - - HYPH cord-006856-b1w25ob5 1582 19 cell cell NN cord-006856-b1w25ob5 1582 20 lymphomas lymphoma NNS cord-006856-b1w25ob5 1582 21 , , , cord-006856-b1w25ob5 1582 22 and and CC cord-006856-b1w25ob5 1582 23 1 1 CD cord-006856-b1w25ob5 1582 24 T t NN cord-006856-b1w25ob5 1582 25 - - HYPH cord-006856-b1w25ob5 1582 26 cell cell NN cord-006856-b1w25ob5 1582 27 lymphoma lymphoma NN cord-006856-b1w25ob5 1582 28 . . . cord-006856-b1w25ob5 1583 1 Immunosuppression Immunosuppression NNP cord-006856-b1w25ob5 1583 2 at at IN cord-006856-b1w25ob5 1583 3 PTLD PTLD NNP cord-006856-b1w25ob5 1583 4 onset onset NN cord-006856-b1w25ob5 1583 5 was be VBD cord-006856-b1w25ob5 1583 6 Calcineurin Calcineurin NNP cord-006856-b1w25ob5 1583 7 inhibitor inhibitor NN cord-006856-b1w25ob5 1583 8 based base VBN cord-006856-b1w25ob5 1583 9 ( ( -LRB- cord-006856-b1w25ob5 1583 10 Cyclosporine Cyclosporine NNP cord-006856-b1w25ob5 1583 11 A A NNP cord-006856-b1w25ob5 1583 12 , , , cord-006856-b1w25ob5 1583 13 5 5 CD cord-006856-b1w25ob5 1583 14 patients patient NNS cord-006856-b1w25ob5 1583 15 ; ; : cord-006856-b1w25ob5 1583 16 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1583 17 , , , cord-006856-b1w25ob5 1583 18 3 3 CD cord-006856-b1w25ob5 1583 19 patients patient NNS cord-006856-b1w25ob5 1583 20 ) ) -RRB- cord-006856-b1w25ob5 1583 21 . . . cord-006856-b1w25ob5 1584 1 Initial initial JJ cord-006856-b1w25ob5 1584 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1584 3 included include VBD cord-006856-b1w25ob5 1584 4 ATG ATG NNP cord-006856-b1w25ob5 1584 5 induction induction NN cord-006856-b1w25ob5 1584 6 . . . cord-006856-b1w25ob5 1585 1 Six six CD cord-006856-b1w25ob5 1585 2 patients patient NNS cord-006856-b1w25ob5 1585 3 received receive VBD cord-006856-b1w25ob5 1585 4 perioperative perioperative JJ cord-006856-b1w25ob5 1585 5 antiviral antiviral JJ cord-006856-b1w25ob5 1585 6 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1585 7 with with IN cord-006856-b1w25ob5 1585 8 either either DT cord-006856-b1w25ob5 1585 9 valgancyclovir valgancyclovir NNP cord-006856-b1w25ob5 1585 10 / / SYM cord-006856-b1w25ob5 1585 11 gancyclovir gancyclovir NNP cord-006856-b1w25ob5 1585 12 ( ( -LRB- cord-006856-b1w25ob5 1585 13 n n NN cord-006856-b1w25ob5 1585 14 = = SYM cord-006856-b1w25ob5 1585 15 4 4 CD cord-006856-b1w25ob5 1585 16 ) ) -RRB- cord-006856-b1w25ob5 1585 17 or or CC cord-006856-b1w25ob5 1585 18 acyclovir acyclovir NNP cord-006856-b1w25ob5 1585 19 ( ( -LRB- cord-006856-b1w25ob5 1585 20 n n NN cord-006856-b1w25ob5 1585 21 = = SYM cord-006856-b1w25ob5 1585 22 2 2 CD cord-006856-b1w25ob5 1585 23 ) ) -RRB- cord-006856-b1w25ob5 1585 24 in in IN cord-006856-b1w25ob5 1585 25 combination combination NN cord-006856-b1w25ob5 1585 26 with with IN cord-006856-b1w25ob5 1585 27 anti anti JJ cord-006856-b1w25ob5 1585 28 - - JJ cord-006856-b1w25ob5 1585 29 CMV CMV NNP cord-006856-b1w25ob5 1585 30 hyperimmunoglobulin hyperimmunoglobulin NN cord-006856-b1w25ob5 1585 31 ( ( -LRB- cord-006856-b1w25ob5 1585 32 n n NN cord-006856-b1w25ob5 1585 33 = = SYM cord-006856-b1w25ob5 1585 34 1 1 CD cord-006856-b1w25ob5 1585 35 ) ) -RRB- cord-006856-b1w25ob5 1585 36 . . . cord-006856-b1w25ob5 1586 1 Two two CD cord-006856-b1w25ob5 1586 2 patients patient NNS cord-006856-b1w25ob5 1586 3 experienced experience VBD cord-006856-b1w25ob5 1586 4 a a DT cord-006856-b1w25ob5 1586 5 total total NN cord-006856-b1w25ob5 1586 6 of of IN cord-006856-b1w25ob5 1586 7 five five CD cord-006856-b1w25ob5 1586 8 episodes episode NNS cord-006856-b1w25ob5 1586 9 of of IN cord-006856-b1w25ob5 1586 10 acute acute JJ cord-006856-b1w25ob5 1586 11 rejection rejection NN cord-006856-b1w25ob5 1586 12 ( ( -LRB- cord-006856-b1w25ob5 1586 13 ISHLT ISHLT NNP cord-006856-b1w25ob5 1586 14 II II NNP cord-006856-b1w25ob5 1586 15 ° ° NN cord-006856-b1w25ob5 1586 16 ) ) -RRB- cord-006856-b1w25ob5 1586 17 , , , cord-006856-b1w25ob5 1586 18 all all DT cord-006856-b1w25ob5 1586 19 were be VBD cord-006856-b1w25ob5 1586 20 treated treat VBN cord-006856-b1w25ob5 1586 21 with with IN cord-006856-b1w25ob5 1586 22 bolused boluse VBN cord-006856-b1w25ob5 1586 23 steroids steroid NNS cord-006856-b1w25ob5 1586 24 . . . cord-006856-b1w25ob5 1587 1 Four four CD cord-006856-b1w25ob5 1587 2 patients patient NNS cord-006856-b1w25ob5 1587 3 are be VBP cord-006856-b1w25ob5 1587 4 still still RB cord-006856-b1w25ob5 1587 5 alive alive JJ cord-006856-b1w25ob5 1587 6 ( ( -LRB- cord-006856-b1w25ob5 1587 7 50 50 CD cord-006856-b1w25ob5 1587 8 % % NN cord-006856-b1w25ob5 1587 9 ) ) -RRB- cord-006856-b1w25ob5 1587 10 , , , cord-006856-b1w25ob5 1587 11 three three CD cord-006856-b1w25ob5 1587 12 of of IN cord-006856-b1w25ob5 1587 13 them -PRON- PRP cord-006856-b1w25ob5 1587 14 in in IN cord-006856-b1w25ob5 1587 15 current current JJ cord-006856-b1w25ob5 1587 16 remission remission NN cord-006856-b1w25ob5 1587 17 of of IN cord-006856-b1w25ob5 1587 18 PTLD PTLD NNP cord-006856-b1w25ob5 1587 19 , , , cord-006856-b1w25ob5 1587 20 one one CD cord-006856-b1w25ob5 1587 21 patient patient NN cord-006856-b1w25ob5 1587 22 is be VBZ cord-006856-b1w25ob5 1587 23 under under IN cord-006856-b1w25ob5 1587 24 therapy therapy NN cord-006856-b1w25ob5 1587 25 recently recently RB cord-006856-b1w25ob5 1587 26 . . . cord-006856-b1w25ob5 1588 1 Median median JJ cord-006856-b1w25ob5 1588 2 survival survival NN cord-006856-b1w25ob5 1588 3 was be VBD cord-006856-b1w25ob5 1588 4 27 27 CD cord-006856-b1w25ob5 1588 5 months month NNS cord-006856-b1w25ob5 1588 6 in in IN cord-006856-b1w25ob5 1588 7 survivors survivor NNS cord-006856-b1w25ob5 1588 8 and and CC cord-006856-b1w25ob5 1588 9 3.4 3.4 CD cord-006856-b1w25ob5 1588 10 months month NNS cord-006856-b1w25ob5 1588 11 in in IN cord-006856-b1w25ob5 1588 12 nonsurvivors nonsurvivor NNS cord-006856-b1w25ob5 1588 13 . . . cord-006856-b1w25ob5 1589 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1589 2 . . . cord-006856-b1w25ob5 1590 1 These these DT cord-006856-b1w25ob5 1590 2 data datum NNS cord-006856-b1w25ob5 1590 3 show show VBP cord-006856-b1w25ob5 1590 4 that that IN cord-006856-b1w25ob5 1590 5 PTLD PTLD NNP cord-006856-b1w25ob5 1590 6 is be VBZ cord-006856-b1w25ob5 1590 7 associated associate VBN cord-006856-b1w25ob5 1590 8 with with IN cord-006856-b1w25ob5 1590 9 a a DT cord-006856-b1w25ob5 1590 10 high high JJ cord-006856-b1w25ob5 1590 11 mortality mortality NN cord-006856-b1w25ob5 1590 12 rate rate NN cord-006856-b1w25ob5 1590 13 . . . cord-006856-b1w25ob5 1591 1 The the DT cord-006856-b1w25ob5 1591 2 majority majority NN cord-006856-b1w25ob5 1591 3 of of IN cord-006856-b1w25ob5 1591 4 PTLDs ptld NNS cord-006856-b1w25ob5 1591 5 are be VBP cord-006856-b1w25ob5 1591 6 EBVassociated ebvassociate VBN cord-006856-b1w25ob5 1591 7 . . . cord-006856-b1w25ob5 1592 1 Therefore therefore RB cord-006856-b1w25ob5 1592 2 , , , cord-006856-b1w25ob5 1592 3 screening screen VBG cord-006856-b1w25ob5 1592 4 for for IN cord-006856-b1w25ob5 1592 5 EBV EBV NNP cord-006856-b1w25ob5 1592 6 infection infection NN cord-006856-b1w25ob5 1592 7 and and CC cord-006856-b1w25ob5 1592 8 prophylactic prophylactic JJ cord-006856-b1w25ob5 1592 9 treatment treatment NN cord-006856-b1w25ob5 1592 10 may may MD cord-006856-b1w25ob5 1592 11 help help VB cord-006856-b1w25ob5 1592 12 to to TO cord-006856-b1w25ob5 1592 13 prevent prevent VB cord-006856-b1w25ob5 1592 14 a a DT cord-006856-b1w25ob5 1592 15 potentially potentially RB cord-006856-b1w25ob5 1592 16 fatal fatal JJ cord-006856-b1w25ob5 1592 17 consequence consequence NN cord-006856-b1w25ob5 1592 18 of of IN cord-006856-b1w25ob5 1592 19 heart heart NN cord-006856-b1w25ob5 1592 20 transplantation transplantation NN cord-006856-b1w25ob5 1592 21 . . . cord-006856-b1w25ob5 1593 1 Background background NN cord-006856-b1w25ob5 1593 2 . . . cord-006856-b1w25ob5 1594 1 Late late JJ cord-006856-b1w25ob5 1594 2 acute acute JJ cord-006856-b1w25ob5 1594 3 cellular cellular JJ cord-006856-b1w25ob5 1594 4 rejection rejection NN cord-006856-b1w25ob5 1594 5 is be VBZ cord-006856-b1w25ob5 1594 6 associated associate VBN cord-006856-b1w25ob5 1594 7 with with IN cord-006856-b1w25ob5 1594 8 a a DT cord-006856-b1w25ob5 1594 9 decrease decrease NN cord-006856-b1w25ob5 1594 10 of of IN cord-006856-b1w25ob5 1594 11 survival survival NN cord-006856-b1w25ob5 1594 12 and and CC cord-006856-b1w25ob5 1594 13 the the DT cord-006856-b1w25ob5 1594 14 development development NN cord-006856-b1w25ob5 1594 15 of of IN cord-006856-b1w25ob5 1594 16 CAV CAV NNP cord-006856-b1w25ob5 1594 17 . . . cord-006856-b1w25ob5 1595 1 New new JJ cord-006856-b1w25ob5 1595 2 immunosuppressice immunosuppressice NN cord-006856-b1w25ob5 1595 3 drugs drug NNS cord-006856-b1w25ob5 1595 4 have have VBP cord-006856-b1w25ob5 1595 5 been be VBN cord-006856-b1w25ob5 1595 6 introduced introduce VBN cord-006856-b1w25ob5 1595 7 into into IN cord-006856-b1w25ob5 1595 8 clinical clinical JJ cord-006856-b1w25ob5 1595 9 practice practice NN cord-006856-b1w25ob5 1595 10 . . . cord-006856-b1w25ob5 1596 1 Everolimus Everolimus NNP cord-006856-b1w25ob5 1596 2 , , , cord-006856-b1w25ob5 1596 3 as as IN cord-006856-b1w25ob5 1596 4 one one CD cord-006856-b1w25ob5 1596 5 of of IN cord-006856-b1w25ob5 1596 6 these these DT cord-006856-b1w25ob5 1596 7 , , , cord-006856-b1w25ob5 1596 8 has have VBZ cord-006856-b1w25ob5 1596 9 shown show VBN cord-006856-b1w25ob5 1596 10 to to TO cord-006856-b1w25ob5 1596 11 be be VB cord-006856-b1w25ob5 1596 12 safe safe JJ cord-006856-b1w25ob5 1596 13 in in IN cord-006856-b1w25ob5 1596 14 cardiac cardiac JJ cord-006856-b1w25ob5 1596 15 transplantation transplantation NN cord-006856-b1w25ob5 1596 16 . . . cord-006856-b1w25ob5 1597 1 We -PRON- PRP cord-006856-b1w25ob5 1597 2 report report VBP cord-006856-b1w25ob5 1597 3 of of IN cord-006856-b1w25ob5 1597 4 our -PRON- PRP$ cord-006856-b1w25ob5 1597 5 experience experience NN cord-006856-b1w25ob5 1597 6 with with IN cord-006856-b1w25ob5 1597 7 Everolimus Everolimus NNP cord-006856-b1w25ob5 1597 8 in in IN cord-006856-b1w25ob5 1597 9 heart heart NN cord-006856-b1w25ob5 1597 10 transplant transplant NN cord-006856-b1w25ob5 1597 11 recipients recipient NNS cord-006856-b1w25ob5 1597 12 who who WP cord-006856-b1w25ob5 1597 13 developed develop VBD cord-006856-b1w25ob5 1597 14 late late JJ cord-006856-b1w25ob5 1597 15 cardiac cardiac JJ cord-006856-b1w25ob5 1597 16 rejection rejection NN cord-006856-b1w25ob5 1597 17 . . . cord-006856-b1w25ob5 1598 1 Methods method NNS cord-006856-b1w25ob5 1598 2 . . . cord-006856-b1w25ob5 1599 1 Patients patient NNS cord-006856-b1w25ob5 1599 2 with with IN cord-006856-b1w25ob5 1599 3 a a DT cord-006856-b1w25ob5 1599 4 history history NN cord-006856-b1w25ob5 1599 5 of of IN cord-006856-b1w25ob5 1599 6 previous previous JJ cord-006856-b1w25ob5 1599 7 rejection rejection NN cord-006856-b1w25ob5 1599 8 episodes episode NNS cord-006856-b1w25ob5 1599 9 who who WP cord-006856-b1w25ob5 1599 10 experienced experience VBD cord-006856-b1w25ob5 1599 11 cardiac cardiac JJ cord-006856-b1w25ob5 1599 12 rejection rejection NN cord-006856-b1w25ob5 1599 13 after after IN cord-006856-b1w25ob5 1599 14 at at RB cord-006856-b1w25ob5 1599 15 least least JJS cord-006856-b1w25ob5 1599 16 2 2 CD cord-006856-b1w25ob5 1599 17 months month NNS cord-006856-b1w25ob5 1599 18 postoperative postoperative JJ cord-006856-b1w25ob5 1599 19 were be VBD cord-006856-b1w25ob5 1599 20 switched switch VBN cord-006856-b1w25ob5 1599 21 to to IN cord-006856-b1w25ob5 1599 22 an an DT cord-006856-b1w25ob5 1599 23 Everolimus Everolimus NNP cord-006856-b1w25ob5 1599 24 , , , cord-006856-b1w25ob5 1599 25 cyclosporine cyclosporine NN cord-006856-b1w25ob5 1599 26 A a NN cord-006856-b1w25ob5 1599 27 , , , cord-006856-b1w25ob5 1599 28 and and CC cord-006856-b1w25ob5 1599 29 corticosteroid corticosteroid NN cord-006856-b1w25ob5 1599 30 - - HYPH cord-006856-b1w25ob5 1599 31 based base VBN cord-006856-b1w25ob5 1599 32 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1599 33 regime regime NN cord-006856-b1w25ob5 1599 34 . . . cord-006856-b1w25ob5 1600 1 All all DT cord-006856-b1w25ob5 1600 2 patients patient NNS cord-006856-b1w25ob5 1600 3 already already RB cord-006856-b1w25ob5 1600 4 received receive VBD cord-006856-b1w25ob5 1600 5 statins statin NNS cord-006856-b1w25ob5 1600 6 and and CC cord-006856-b1w25ob5 1600 7 antihypertensive antihypertensive JJ cord-006856-b1w25ob5 1600 8 medication medication NN cord-006856-b1w25ob5 1600 9 before before RB cord-006856-b1w25ob5 1600 10 . . . cord-006856-b1w25ob5 1601 1 Everolimus Everolimus NNP cord-006856-b1w25ob5 1601 2 , , , cord-006856-b1w25ob5 1601 3 cyclosporine cyclosporine NN cord-006856-b1w25ob5 1601 4 A a DT cord-006856-b1w25ob5 1601 5 trough trough NN cord-006856-b1w25ob5 1601 6 levels level NNS cord-006856-b1w25ob5 1601 7 and and CC cord-006856-b1w25ob5 1601 8 laboratory laboratory NN cord-006856-b1w25ob5 1601 9 values value NNS cord-006856-b1w25ob5 1601 10 were be VBD cord-006856-b1w25ob5 1601 11 controlled control VBN cord-006856-b1w25ob5 1601 12 monthly monthly RB cord-006856-b1w25ob5 1601 13 . . . cord-006856-b1w25ob5 1602 1 Drug Drug NNP cord-006856-b1w25ob5 1602 2 administration administration NN cord-006856-b1w25ob5 1602 3 was be VBD cord-006856-b1w25ob5 1602 4 adapted adapt VBN cord-006856-b1w25ob5 1602 5 to to IN cord-006856-b1w25ob5 1602 6 an an DT cord-006856-b1w25ob5 1602 7 Everolimus Everolimus NNP cord-006856-b1w25ob5 1602 8 trough trough NN cord-006856-b1w25ob5 1602 9 level level NN cord-006856-b1w25ob5 1602 10 between between IN cord-006856-b1w25ob5 1602 11 3 3 CD cord-006856-b1w25ob5 1602 12 and and CC cord-006856-b1w25ob5 1602 13 8 8 CD cord-006856-b1w25ob5 1602 14 ng ng NN cord-006856-b1w25ob5 1602 15 / / SYM cord-006856-b1w25ob5 1602 16 ml ml NNS cord-006856-b1w25ob5 1602 17 , , , cord-006856-b1w25ob5 1602 18 mean mean JJ cord-006856-b1w25ob5 1602 19 maintenance maintenance NN cord-006856-b1w25ob5 1602 20 dosage dosage NN cord-006856-b1w25ob5 1602 21 was be VBD cord-006856-b1w25ob5 1602 22 at at IN cord-006856-b1w25ob5 1602 23 0.25 0.25 CD cord-006856-b1w25ob5 1602 24 to to TO cord-006856-b1w25ob5 1602 25 1.5 1.5 CD cord-006856-b1w25ob5 1602 26 mg mg NNP cord-006856-b1w25ob5 1602 27 / / SYM cord-006856-b1w25ob5 1602 28 day day NN cord-006856-b1w25ob5 1602 29 . . . cord-006856-b1w25ob5 1603 1 Death death NN cord-006856-b1w25ob5 1603 2 , , , cord-006856-b1w25ob5 1603 3 safety safety NN cord-006856-b1w25ob5 1603 4 , , , cord-006856-b1w25ob5 1603 5 side side NN cord-006856-b1w25ob5 1603 6 effects effect NNS cord-006856-b1w25ob5 1603 7 , , , cord-006856-b1w25ob5 1603 8 biopsy biopsy NN cord-006856-b1w25ob5 1603 9 - - HYPH cord-006856-b1w25ob5 1603 10 proven prove VBN cord-006856-b1w25ob5 1603 11 acute acute JJ cord-006856-b1w25ob5 1603 12 rejection rejection NN cord-006856-b1w25ob5 1603 13 , , , cord-006856-b1w25ob5 1603 14 laboratory laboratory NN cord-006856-b1w25ob5 1603 15 values value NNS cord-006856-b1w25ob5 1603 16 and and CC cord-006856-b1w25ob5 1603 17 blood blood NN cord-006856-b1w25ob5 1603 18 levels level NNS cord-006856-b1w25ob5 1603 19 were be VBD cord-006856-b1w25ob5 1603 20 evaluated evaluate VBN cord-006856-b1w25ob5 1603 21 retrospectively retrospectively RB cord-006856-b1w25ob5 1603 22 . . . cord-006856-b1w25ob5 1604 1 Results result NNS cord-006856-b1w25ob5 1604 2 . . . cord-006856-b1w25ob5 1605 1 4 4 CD cord-006856-b1w25ob5 1605 2 cardiac cardiac NN cord-006856-b1w25ob5 1605 3 allograft allograft NN cord-006856-b1w25ob5 1605 4 recipients recipient NNS cord-006856-b1w25ob5 1605 5 ( ( -LRB- cord-006856-b1w25ob5 1605 6 2 2 CD cord-006856-b1w25ob5 1605 7 male male NN cord-006856-b1w25ob5 1605 8 , , , cord-006856-b1w25ob5 1605 9 2 2 CD cord-006856-b1w25ob5 1605 10 female female JJ cord-006856-b1w25ob5 1605 11 ) ) -RRB- cord-006856-b1w25ob5 1605 12 , , , cord-006856-b1w25ob5 1605 13 at at IN cord-006856-b1w25ob5 1605 14 a a DT cord-006856-b1w25ob5 1605 15 median median NN cord-006856-b1w25ob5 1605 16 of of IN cord-006856-b1w25ob5 1605 17 1473.25 1473.25 CD cord-006856-b1w25ob5 1605 18 days day NNS cord-006856-b1w25ob5 1605 19 post post NNP cord-006856-b1w25ob5 1605 20 orthotopic orthotopic JJ cord-006856-b1w25ob5 1605 21 heart heart NN cord-006856-b1w25ob5 1605 22 transplantation transplantation NN cord-006856-b1w25ob5 1605 23 ( ( -LRB- cord-006856-b1w25ob5 1605 24 oHTx ohtx LS cord-006856-b1w25ob5 1605 25 ) ) -RRB- cord-006856-b1w25ob5 1605 26 ( ( -LRB- cord-006856-b1w25ob5 1605 27 65 65 CD cord-006856-b1w25ob5 1605 28 - - SYM cord-006856-b1w25ob5 1605 29 3045 3045 CD cord-006856-b1w25ob5 1605 30 ) ) -RRB- cord-006856-b1w25ob5 1605 31 , , , cord-006856-b1w25ob5 1605 32 received receive VBD cord-006856-b1w25ob5 1605 33 1 1 CD cord-006856-b1w25ob5 1605 34 mg mg NN cord-006856-b1w25ob5 1605 35 to to IN cord-006856-b1w25ob5 1605 36 1.5 1.5 CD cord-006856-b1w25ob5 1605 37 mg mg NNP cord-006856-b1w25ob5 1605 38 Everolimus Everolimus NNP cord-006856-b1w25ob5 1605 39 per per IN cord-006856-b1w25ob5 1605 40 day day NN cord-006856-b1w25ob5 1605 41 . . . cord-006856-b1w25ob5 1606 1 In in IN cord-006856-b1w25ob5 1606 2 a a DT cord-006856-b1w25ob5 1606 3 follow follow NN cord-006856-b1w25ob5 1606 4 - - HYPH cord-006856-b1w25ob5 1606 5 up up NN cord-006856-b1w25ob5 1606 6 period period NN cord-006856-b1w25ob5 1606 7 of of IN cord-006856-b1w25ob5 1606 8 at at RB cord-006856-b1w25ob5 1606 9 least least RBS cord-006856-b1w25ob5 1606 10 2 2 CD cord-006856-b1w25ob5 1606 11 month month NN cord-006856-b1w25ob5 1606 12 ( ( -LRB- cord-006856-b1w25ob5 1606 13 2 2 CD cord-006856-b1w25ob5 1606 14 - - SYM cord-006856-b1w25ob5 1606 15 10 10 CD cord-006856-b1w25ob5 1606 16 ) ) -RRB- cord-006856-b1w25ob5 1606 17 mortality mortality NN cord-006856-b1w25ob5 1606 18 was be VBD cord-006856-b1w25ob5 1606 19 0 0 CD cord-006856-b1w25ob5 1606 20 % % NN cord-006856-b1w25ob5 1606 21 . . . cord-006856-b1w25ob5 1607 1 The the DT cord-006856-b1w25ob5 1607 2 drug drug NN cord-006856-b1w25ob5 1607 3 was be VBD cord-006856-b1w25ob5 1607 4 well well RB cord-006856-b1w25ob5 1607 5 tolerated tolerate VBN cord-006856-b1w25ob5 1607 6 and and CC cord-006856-b1w25ob5 1607 7 no no DT cord-006856-b1w25ob5 1607 8 acute acute JJ cord-006856-b1w25ob5 1607 9 cellular cellular JJ cord-006856-b1w25ob5 1607 10 rejection rejection NN cord-006856-b1w25ob5 1607 11 greater great JJR cord-006856-b1w25ob5 1607 12 than than IN cord-006856-b1w25ob5 1607 13 grade grade NN cord-006856-b1w25ob5 1607 14 1a 1a CD cord-006856-b1w25ob5 1607 15 ( ( -LRB- cord-006856-b1w25ob5 1607 16 ISHLT ISHLT NNP cord-006856-b1w25ob5 1607 17 grading grading NN cord-006856-b1w25ob5 1607 18 ) ) -RRB- cord-006856-b1w25ob5 1607 19 was be VBD cord-006856-b1w25ob5 1607 20 observed observe VBN cord-006856-b1w25ob5 1607 21 after after IN cord-006856-b1w25ob5 1607 22 two two CD cord-006856-b1w25ob5 1607 23 month month NN cord-006856-b1w25ob5 1607 24 . . . cord-006856-b1w25ob5 1608 1 In in IN cord-006856-b1w25ob5 1608 2 one one CD cord-006856-b1w25ob5 1608 3 patient patient NN cord-006856-b1w25ob5 1608 4 raised raise VBD cord-006856-b1w25ob5 1608 5 cholesterol cholesterol NN cord-006856-b1w25ob5 1608 6 values value NNS cord-006856-b1w25ob5 1608 7 and and CC cord-006856-b1w25ob5 1608 8 in in IN cord-006856-b1w25ob5 1608 9 two two CD cord-006856-b1w25ob5 1608 10 others other NNS cord-006856-b1w25ob5 1608 11 elevated elevate VBD cord-006856-b1w25ob5 1608 12 triglyceride triglyceride NN cord-006856-b1w25ob5 1608 13 levels level NNS cord-006856-b1w25ob5 1608 14 were be VBD cord-006856-b1w25ob5 1608 15 seen see VBN cord-006856-b1w25ob5 1608 16 but but CC cord-006856-b1w25ob5 1608 17 were be VBD cord-006856-b1w25ob5 1608 18 controlled control VBN cord-006856-b1w25ob5 1608 19 with with IN cord-006856-b1w25ob5 1608 20 higher high JJR cord-006856-b1w25ob5 1608 21 statine statine NN cord-006856-b1w25ob5 1608 22 therapy therapy NN cord-006856-b1w25ob5 1608 23 . . . cord-006856-b1w25ob5 1609 1 No no DT cord-006856-b1w25ob5 1609 2 obvious obvious JJ cord-006856-b1w25ob5 1609 3 raised raise VBD cord-006856-b1w25ob5 1609 4 creatinine creatinine NN cord-006856-b1w25ob5 1609 5 values value NNS cord-006856-b1w25ob5 1609 6 were be VBD cord-006856-b1w25ob5 1609 7 seen see VBN cord-006856-b1w25ob5 1609 8 with with IN cord-006856-b1w25ob5 1609 9 Certican Certican NNP cord-006856-b1w25ob5 1609 10 ® ® NNP cord-006856-b1w25ob5 1609 11 . . . cord-006856-b1w25ob5 1609 12 Conclusions conclusion NNS cord-006856-b1w25ob5 1609 13 . . . cord-006856-b1w25ob5 1610 1 In in IN cord-006856-b1w25ob5 1610 2 conclusion conclusion NN cord-006856-b1w25ob5 1610 3 , , , cord-006856-b1w25ob5 1610 4 conversion conversion NN cord-006856-b1w25ob5 1610 5 to to IN cord-006856-b1w25ob5 1610 6 an an DT cord-006856-b1w25ob5 1610 7 Everolimus Everolimus NNP cord-006856-b1w25ob5 1610 8 - - HYPH cord-006856-b1w25ob5 1610 9 based base VBN cord-006856-b1w25ob5 1610 10 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1610 11 regimen regimen NN cord-006856-b1w25ob5 1610 12 after after IN cord-006856-b1w25ob5 1610 13 late late JJ cord-006856-b1w25ob5 1610 14 cardiac cardiac JJ cord-006856-b1w25ob5 1610 15 rejection rejection NN cord-006856-b1w25ob5 1610 16 is be VBZ cord-006856-b1w25ob5 1610 17 safe safe JJ cord-006856-b1w25ob5 1610 18 and and CC cord-006856-b1w25ob5 1610 19 effective effective JJ cord-006856-b1w25ob5 1610 20 . . . cord-006856-b1w25ob5 1611 1 No no DT cord-006856-b1w25ob5 1611 2 major major JJ cord-006856-b1w25ob5 1611 3 side side NN cord-006856-b1w25ob5 1611 4 effects effect NNS cord-006856-b1w25ob5 1611 5 were be VBD cord-006856-b1w25ob5 1611 6 observed observe VBN cord-006856-b1w25ob5 1611 7 . . . cord-006856-b1w25ob5 1612 1 P02 P02 NNP cord-006856-b1w25ob5 1612 2 Collagen Collagen NNP cord-006856-b1w25ob5 1612 3 III III NNP cord-006856-b1w25ob5 1612 4 in in IN cord-006856-b1w25ob5 1612 5 transplanted transplant VBN cord-006856-b1w25ob5 1612 6 heartdonor heartdonor NN cord-006856-b1w25ob5 1612 7 or or CC cord-006856-b1w25ob5 1612 8 recipient recipient NN cord-006856-b1w25ob5 1612 9 derived derive VBD cord-006856-b1w25ob5 1612 10 M. M. NNP cord-006856-b1w25ob5 1612 11 Pichler Pichler NNP cord-006856-b1w25ob5 1612 12 , , , cord-006856-b1w25ob5 1612 13 B. B. NNP cord-006856-b1w25ob5 1612 14 Tessaro Tessaro NNP cord-006856-b1w25ob5 1612 15 , , , cord-006856-b1w25ob5 1612 16 D. D. NNP cord-006856-b1w25ob5 1612 17 Kniepeiss Kniepeiss NNP cord-006856-b1w25ob5 1612 18 , , , cord-006856-b1w25ob5 1612 19 R. R. NNP cord-006856-b1w25ob5 1612 20 Kleinert Kleinert NNP cord-006856-b1w25ob5 1612 21 , , , cord-006856-b1w25ob5 1612 22 G. G. NNP cord-006856-b1w25ob5 1612 23 Hoefler Hoefler NNP cord-006856-b1w25ob5 1612 24 Institute Institute NNP cord-006856-b1w25ob5 1612 25 of of IN cord-006856-b1w25ob5 1612 26 Pathology Pathology NNP cord-006856-b1w25ob5 1612 27 , , , cord-006856-b1w25ob5 1612 28 Medical Medical NNP cord-006856-b1w25ob5 1612 29 University University NNP cord-006856-b1w25ob5 1612 30 of of IN cord-006856-b1w25ob5 1612 31 Graz Graz NNP cord-006856-b1w25ob5 1612 32 , , , cord-006856-b1w25ob5 1612 33 Graz Graz NNP cord-006856-b1w25ob5 1612 34 , , , cord-006856-b1w25ob5 1612 35 Austria Austria NNP cord-006856-b1w25ob5 1612 36 Background Background NNP cord-006856-b1w25ob5 1612 37 . . . cord-006856-b1w25ob5 1613 1 Transplantation transplantation NN cord-006856-b1w25ob5 1613 2 of of IN cord-006856-b1w25ob5 1613 3 donor donor NN cord-006856-b1w25ob5 1613 4 hearts heart NNS cord-006856-b1w25ob5 1613 5 is be VBZ cord-006856-b1w25ob5 1613 6 often often RB cord-006856-b1w25ob5 1613 7 associated associate VBN cord-006856-b1w25ob5 1613 8 with with IN cord-006856-b1w25ob5 1613 9 progressive progressive JJ cord-006856-b1w25ob5 1613 10 development development NN cord-006856-b1w25ob5 1613 11 of of IN cord-006856-b1w25ob5 1613 12 interstitial interstitial JJ cord-006856-b1w25ob5 1613 13 myocardial myocardial JJ cord-006856-b1w25ob5 1613 14 fibrosis fibrosis NN cord-006856-b1w25ob5 1613 15 and and CC cord-006856-b1w25ob5 1613 16 alterations alteration NNS cord-006856-b1w25ob5 1613 17 in in IN cord-006856-b1w25ob5 1613 18 composition composition NN cord-006856-b1w25ob5 1613 19 and and CC cord-006856-b1w25ob5 1613 20 organisation organisation NN cord-006856-b1w25ob5 1613 21 of of IN cord-006856-b1w25ob5 1613 22 the the DT cord-006856-b1w25ob5 1613 23 extracellular extracellular JJ cord-006856-b1w25ob5 1613 24 matrix matrix NN cord-006856-b1w25ob5 1613 25 . . . cord-006856-b1w25ob5 1614 1 Changes change NNS cord-006856-b1w25ob5 1614 2 in in IN cord-006856-b1w25ob5 1614 3 cardiac cardiac JJ cord-006856-b1w25ob5 1614 4 interstitial interstitial JJ cord-006856-b1w25ob5 1614 5 collagen collagen NN cord-006856-b1w25ob5 1614 6 network network NN cord-006856-b1w25ob5 1614 7 are be VBP cord-006856-b1w25ob5 1614 8 thought think VBN cord-006856-b1w25ob5 1614 9 to to TO cord-006856-b1w25ob5 1614 10 contribute contribute VB cord-006856-b1w25ob5 1614 11 to to IN cord-006856-b1w25ob5 1614 12 abnormal abnormal JJ cord-006856-b1w25ob5 1614 13 stiffness stiffness NN cord-006856-b1w25ob5 1614 14 and and CC cord-006856-b1w25ob5 1614 15 loss loss NN cord-006856-b1w25ob5 1614 16 of of IN cord-006856-b1w25ob5 1614 17 function function NN cord-006856-b1w25ob5 1614 18 of of IN cord-006856-b1w25ob5 1614 19 the the DT cord-006856-b1w25ob5 1614 20 myocardium myocardium NN cord-006856-b1w25ob5 1614 21 . . . cord-006856-b1w25ob5 1615 1 Fibroblasts fibroblast NNS cord-006856-b1w25ob5 1615 2 are be VBP cord-006856-b1w25ob5 1615 3 the the DT cord-006856-b1w25ob5 1615 4 main main JJ cord-006856-b1w25ob5 1615 5 producers producer NNS cord-006856-b1w25ob5 1615 6 of of IN cord-006856-b1w25ob5 1615 7 type type NN cord-006856-b1w25ob5 1615 8 I -PRON- PRP cord-006856-b1w25ob5 1615 9 and and CC cord-006856-b1w25ob5 1615 10 type type NN cord-006856-b1w25ob5 1615 11 III iii CD cord-006856-b1w25ob5 1615 12 collagens collagen NNS cord-006856-b1w25ob5 1615 13 , , , cord-006856-b1w25ob5 1615 14 the the DT cord-006856-b1w25ob5 1615 15 major major JJ cord-006856-b1w25ob5 1615 16 in in IN cord-006856-b1w25ob5 1615 17 - - HYPH cord-006856-b1w25ob5 1615 18 Poster poster NN cord-006856-b1w25ob5 1615 19 terstitial terstitial JJ cord-006856-b1w25ob5 1615 20 collagens collagen NNS cord-006856-b1w25ob5 1615 21 found find VBN cord-006856-b1w25ob5 1615 22 in in IN cord-006856-b1w25ob5 1615 23 the the DT cord-006856-b1w25ob5 1615 24 heart heart NN cord-006856-b1w25ob5 1615 25 . . . cord-006856-b1w25ob5 1616 1 In in IN cord-006856-b1w25ob5 1616 2 transplanted transplanted JJ cord-006856-b1w25ob5 1616 3 hearts heart NNS cord-006856-b1w25ob5 1616 4 , , , cord-006856-b1w25ob5 1616 5 intragraft intragraft NN cord-006856-b1w25ob5 1616 6 fibroblasts fibroblast NNS cord-006856-b1w25ob5 1616 7 may may MD cord-006856-b1w25ob5 1616 8 consist consist VB cord-006856-b1w25ob5 1616 9 of of IN cord-006856-b1w25ob5 1616 10 two two CD cord-006856-b1w25ob5 1616 11 cell cell NN cord-006856-b1w25ob5 1616 12 populations population NNS cord-006856-b1w25ob5 1616 13 . . . cord-006856-b1w25ob5 1617 1 Donor donor NN cord-006856-b1w25ob5 1617 2 - - HYPH cord-006856-b1w25ob5 1617 3 derived derive VBN cord-006856-b1w25ob5 1617 4 fibroblasts fibroblast NNS cord-006856-b1w25ob5 1617 5 preexist preexist VBP cord-006856-b1w25ob5 1617 6 in in IN cord-006856-b1w25ob5 1617 7 donor donor NN cord-006856-b1w25ob5 1617 8 organs organ NNS cord-006856-b1w25ob5 1617 9 , , , cord-006856-b1w25ob5 1617 10 whereas whereas IN cord-006856-b1w25ob5 1617 11 hostderived hostderive VBN cord-006856-b1w25ob5 1617 12 fibroblasts fibroblast NNS cord-006856-b1w25ob5 1617 13 may may MD cord-006856-b1w25ob5 1617 14 progressively progressively RB cord-006856-b1w25ob5 1617 15 immigrate immigrate VB cord-006856-b1w25ob5 1617 16 as as IN cord-006856-b1w25ob5 1617 17 mesenchymal mesenchymal JJ cord-006856-b1w25ob5 1617 18 progenitors progenitor NNS cord-006856-b1w25ob5 1617 19 from from IN cord-006856-b1w25ob5 1617 20 the the DT cord-006856-b1w25ob5 1617 21 circulation circulation NN cord-006856-b1w25ob5 1617 22 to to IN cord-006856-b1w25ob5 1617 23 the the DT cord-006856-b1w25ob5 1617 24 allograft allograft NN cord-006856-b1w25ob5 1617 25 . . . cord-006856-b1w25ob5 1618 1 Purpose purpose NN cord-006856-b1w25ob5 1618 2 of of IN cord-006856-b1w25ob5 1618 3 the the DT cord-006856-b1w25ob5 1618 4 study study NN cord-006856-b1w25ob5 1618 5 . . . cord-006856-b1w25ob5 1619 1 To to TO cord-006856-b1w25ob5 1619 2 determine determine VB cord-006856-b1w25ob5 1619 3 the the DT cord-006856-b1w25ob5 1619 4 contribution contribution NN cord-006856-b1w25ob5 1619 5 of of IN cord-006856-b1w25ob5 1619 6 these these DT cord-006856-b1w25ob5 1619 7 two two CD cord-006856-b1w25ob5 1619 8 distinct distinct JJ cord-006856-b1w25ob5 1619 9 fibroblast fibroblast NN cord-006856-b1w25ob5 1619 10 populations population NNS cord-006856-b1w25ob5 1619 11 to to IN cord-006856-b1w25ob5 1619 12 progression progression NN cord-006856-b1w25ob5 1619 13 of of IN cord-006856-b1w25ob5 1619 14 myocardial myocardial JJ cord-006856-b1w25ob5 1619 15 fibrosis fibrosis NN cord-006856-b1w25ob5 1619 16 , , , cord-006856-b1w25ob5 1619 17 we -PRON- PRP cord-006856-b1w25ob5 1619 18 studied study VBD cord-006856-b1w25ob5 1619 19 endomyocardial endomyocardial JJ cord-006856-b1w25ob5 1619 20 biopsies biopsy NNS cord-006856-b1w25ob5 1619 21 over over IN cord-006856-b1w25ob5 1619 22 a a DT cord-006856-b1w25ob5 1619 23 time time NN cord-006856-b1w25ob5 1619 24 period period NN cord-006856-b1w25ob5 1619 25 of of IN cord-006856-b1w25ob5 1619 26 some some DT cord-006856-b1w25ob5 1619 27 years year NNS cord-006856-b1w25ob5 1619 28 from from IN cord-006856-b1w25ob5 1619 29 a a DT cord-006856-b1w25ob5 1619 30 male male JJ cord-006856-b1w25ob5 1619 31 patient patient NN cord-006856-b1w25ob5 1619 32 who who WP cord-006856-b1w25ob5 1619 33 had have VBD cord-006856-b1w25ob5 1619 34 received receive VBN cord-006856-b1w25ob5 1619 35 a a DT cord-006856-b1w25ob5 1619 36 heart heart NN cord-006856-b1w25ob5 1619 37 from from IN cord-006856-b1w25ob5 1619 38 a a DT cord-006856-b1w25ob5 1619 39 female female JJ cord-006856-b1w25ob5 1619 40 donor donor NN cord-006856-b1w25ob5 1619 41 . . . cord-006856-b1w25ob5 1620 1 Methods method NNS cord-006856-b1w25ob5 1620 2 . . . cord-006856-b1w25ob5 1621 1 In in IN cord-006856-b1w25ob5 1621 2 these these DT cord-006856-b1w25ob5 1621 3 sex sex NN cord-006856-b1w25ob5 1621 4 - - HYPH cord-006856-b1w25ob5 1621 5 mismatched mismatch VBN cord-006856-b1w25ob5 1621 6 patients patient NNS cord-006856-b1w25ob5 1621 7 two two CD cord-006856-b1w25ob5 1621 8 frequent frequent JJ cord-006856-b1w25ob5 1621 9 genetic genetic JJ cord-006856-b1w25ob5 1621 10 polymorphisms polymorphism NNS cord-006856-b1w25ob5 1621 11 at at IN cord-006856-b1w25ob5 1621 12 the the DT cord-006856-b1w25ob5 1621 13 collagen collagen NN cord-006856-b1w25ob5 1621 14 III iii CD cord-006856-b1w25ob5 1621 15 locus locus NN cord-006856-b1w25ob5 1621 16 were be VBD cord-006856-b1w25ob5 1621 17 determined determine VBN cord-006856-b1w25ob5 1621 18 by by IN cord-006856-b1w25ob5 1621 19 polymerase polymerase NN cord-006856-b1w25ob5 1621 20 chain chain NN cord-006856-b1w25ob5 1621 21 reaction reaction NN cord-006856-b1w25ob5 1621 22 - - HYPH cord-006856-b1w25ob5 1621 23 based base VBN cord-006856-b1w25ob5 1621 24 restriction restriction NN cord-006856-b1w25ob5 1621 25 enzyme enzyme NN cord-006856-b1w25ob5 1621 26 digestion digestion NN cord-006856-b1w25ob5 1621 27 , , , cord-006856-b1w25ob5 1621 28 both both CC cord-006856-b1w25ob5 1621 29 in in IN cord-006856-b1w25ob5 1621 30 donor donor NN cord-006856-b1w25ob5 1621 31 allograft allograft NN cord-006856-b1w25ob5 1621 32 and and CC cord-006856-b1w25ob5 1621 33 in in IN cord-006856-b1w25ob5 1621 34 the the DT cord-006856-b1w25ob5 1621 35 corresponding corresponding JJ cord-006856-b1w25ob5 1621 36 explanted explanted JJ cord-006856-b1w25ob5 1621 37 recipient recipient NN cord-006856-b1w25ob5 1621 38 heart heart NN cord-006856-b1w25ob5 1621 39 . . . cord-006856-b1w25ob5 1622 1 On on IN cord-006856-b1w25ob5 1622 2 the the DT cord-006856-b1w25ob5 1622 3 basis basis NN cord-006856-b1w25ob5 1622 4 of of IN cord-006856-b1w25ob5 1622 5 differences difference NNS cord-006856-b1w25ob5 1622 6 of of IN cord-006856-b1w25ob5 1622 7 the the DT cord-006856-b1w25ob5 1622 8 collagen collagen NN cord-006856-b1w25ob5 1622 9 genotype genotype NN cord-006856-b1w25ob5 1622 10 in in IN cord-006856-b1w25ob5 1622 11 donor donor NN cord-006856-b1w25ob5 1622 12 and and CC cord-006856-b1w25ob5 1622 13 recipient recipient NN cord-006856-b1w25ob5 1622 14 tissue tissue NN cord-006856-b1w25ob5 1622 15 , , , cord-006856-b1w25ob5 1622 16 we -PRON- PRP cord-006856-b1w25ob5 1622 17 selected select VBD cord-006856-b1w25ob5 1622 18 10 10 CD cord-006856-b1w25ob5 1622 19 endomyocardial endomyocardial JJ cord-006856-b1w25ob5 1622 20 biopsies biopsy NNS cord-006856-b1w25ob5 1622 21 by by IN cord-006856-b1w25ob5 1622 22 hematoxylin hematoxylin NNP cord-006856-b1w25ob5 1622 23 eosin eosin NNP cord-006856-b1w25ob5 1622 24 staining stain VBG cord-006856-b1w25ob5 1622 25 covering cover VBG cord-006856-b1w25ob5 1622 26 an an DT cord-006856-b1w25ob5 1622 27 overall overall JJ cord-006856-b1w25ob5 1622 28 follow follow NN cord-006856-b1w25ob5 1622 29 - - HYPH cord-006856-b1w25ob5 1622 30 up up NN cord-006856-b1w25ob5 1622 31 period period NN cord-006856-b1w25ob5 1622 32 of of IN cord-006856-b1w25ob5 1622 33 nine nine CD cord-006856-b1w25ob5 1622 34 years year NNS cord-006856-b1w25ob5 1622 35 since since IN cord-006856-b1w25ob5 1622 36 the the DT cord-006856-b1w25ob5 1622 37 transplantation transplantation NN cord-006856-b1w25ob5 1622 38 event event NN cord-006856-b1w25ob5 1622 39 . . . cord-006856-b1w25ob5 1623 1 Immunohistochemistry Immunohistochemistry NNP cord-006856-b1w25ob5 1623 2 , , , cord-006856-b1w25ob5 1623 3 chromogene chromogene NN cord-006856-b1w25ob5 1623 4 in in IN cord-006856-b1w25ob5 1623 5 situ situ NN cord-006856-b1w25ob5 1623 6 hybridisation hybridisation NN cord-006856-b1w25ob5 1623 7 , , , cord-006856-b1w25ob5 1623 8 and and CC cord-006856-b1w25ob5 1623 9 population population NN cord-006856-b1w25ob5 1623 10 - - HYPH cord-006856-b1w25ob5 1623 11 specific specific JJ cord-006856-b1w25ob5 1623 12 collagen collagen NN cord-006856-b1w25ob5 1623 13 expression expression NN cord-006856-b1w25ob5 1623 14 using use VBG cord-006856-b1w25ob5 1623 15 single single JJ cord-006856-b1w25ob5 1623 16 nucleotide nucleotide JJ cord-006856-b1w25ob5 1623 17 polymorphisms polymorphism NNS cord-006856-b1w25ob5 1623 18 were be VBD cord-006856-b1w25ob5 1623 19 used use VBN cord-006856-b1w25ob5 1623 20 to to TO cord-006856-b1w25ob5 1623 21 determine determine VB cord-006856-b1w25ob5 1623 22 the the DT cord-006856-b1w25ob5 1623 23 course course NN cord-006856-b1w25ob5 1623 24 of of IN cord-006856-b1w25ob5 1623 25 fibrosis fibrosis NN cord-006856-b1w25ob5 1623 26 . . . cord-006856-b1w25ob5 1624 1 Results result NNS cord-006856-b1w25ob5 1624 2 . . . cord-006856-b1w25ob5 1625 1 We -PRON- PRP cord-006856-b1w25ob5 1625 2 developed develop VBD cord-006856-b1w25ob5 1625 3 an an DT cord-006856-b1w25ob5 1625 4 analytical analytical JJ cord-006856-b1w25ob5 1625 5 system system NN cord-006856-b1w25ob5 1625 6 generally generally RB cord-006856-b1w25ob5 1625 7 applicable applicable JJ cord-006856-b1w25ob5 1625 8 to to TO cord-006856-b1w25ob5 1625 9 measure measure VB cord-006856-b1w25ob5 1625 10 population population NN cord-006856-b1w25ob5 1625 11 - - HYPH cord-006856-b1w25ob5 1625 12 specific specific JJ cord-006856-b1w25ob5 1625 13 differences difference NNS cord-006856-b1w25ob5 1625 14 of of IN cord-006856-b1w25ob5 1625 15 collagen collagen NN cord-006856-b1w25ob5 1625 16 III iii CD cord-006856-b1w25ob5 1625 17 synthesis synthesis NN cord-006856-b1w25ob5 1625 18 in in IN cord-006856-b1w25ob5 1625 19 transplanted transplanted JJ cord-006856-b1w25ob5 1625 20 organs organ NNS cord-006856-b1w25ob5 1625 21 . . . cord-006856-b1w25ob5 1626 1 The the DT cord-006856-b1w25ob5 1626 2 amounts amount NNS cord-006856-b1w25ob5 1626 3 of of IN cord-006856-b1w25ob5 1626 4 interstitial interstitial JJ cord-006856-b1w25ob5 1626 5 collagen collagen NN cord-006856-b1w25ob5 1626 6 type type NN cord-006856-b1w25ob5 1626 7 I -PRON- PRP cord-006856-b1w25ob5 1626 8 and and CC cord-006856-b1w25ob5 1626 9 type type NN cord-006856-b1w25ob5 1626 10 III iii CD cord-006856-b1w25ob5 1626 11 increased increase VBD cord-006856-b1w25ob5 1626 12 in in IN cord-006856-b1w25ob5 1626 13 a a DT cord-006856-b1w25ob5 1626 14 time time NN cord-006856-b1w25ob5 1626 15 - - HYPH cord-006856-b1w25ob5 1626 16 dependent dependent JJ cord-006856-b1w25ob5 1626 17 manner manner NN cord-006856-b1w25ob5 1626 18 within within IN cord-006856-b1w25ob5 1626 19 cardiac cardiac JJ cord-006856-b1w25ob5 1626 20 allograft allograft NN cord-006856-b1w25ob5 1626 21 . . . cord-006856-b1w25ob5 1627 1 Years year NNS cord-006856-b1w25ob5 1627 2 after after IN cord-006856-b1w25ob5 1627 3 transplantation transplantation NN cord-006856-b1w25ob5 1627 4 , , , cord-006856-b1w25ob5 1627 5 a a DT cord-006856-b1w25ob5 1627 6 number number NN cord-006856-b1w25ob5 1627 7 of of IN cord-006856-b1w25ob5 1627 8 Y y NN cord-006856-b1w25ob5 1627 9 - - HYPH cord-006856-b1w25ob5 1627 10 chromosome chromosome NN cord-006856-b1w25ob5 1627 11 - - HYPH cord-006856-b1w25ob5 1627 12 positive positive JJ cord-006856-b1w25ob5 1627 13 recipient recipient NN cord-006856-b1w25ob5 1627 14 - - HYPH cord-006856-b1w25ob5 1627 15 derived derive VBN cord-006856-b1w25ob5 1627 16 cells cell NNS cord-006856-b1w25ob5 1627 17 consisted consist VBN cord-006856-b1w25ob5 1627 18 of of IN cord-006856-b1w25ob5 1627 19 noninflammatory noninflammatory JJ cord-006856-b1w25ob5 1627 20 spindle spindle NN cord-006856-b1w25ob5 1627 21 - - HYPH cord-006856-b1w25ob5 1627 22 shaped shape VBN cord-006856-b1w25ob5 1627 23 fibroblast fibroblast NN cord-006856-b1w25ob5 1627 24 - - HYPH cord-006856-b1w25ob5 1627 25 like like JJ cord-006856-b1w25ob5 1627 26 cell cell NN cord-006856-b1w25ob5 1627 27 types type NNS cord-006856-b1w25ob5 1627 28 . . . cord-006856-b1w25ob5 1628 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1628 2 . . . cord-006856-b1w25ob5 1629 1 Our -PRON- PRP$ cord-006856-b1w25ob5 1629 2 data datum NNS cord-006856-b1w25ob5 1629 3 confirm confirm VBP cord-006856-b1w25ob5 1629 4 the the DT cord-006856-b1w25ob5 1629 5 existence existence NN cord-006856-b1w25ob5 1629 6 of of IN cord-006856-b1w25ob5 1629 7 a a DT cord-006856-b1w25ob5 1629 8 substantial substantial JJ cord-006856-b1w25ob5 1629 9 number number NN cord-006856-b1w25ob5 1629 10 of of IN cord-006856-b1w25ob5 1629 11 fibrosis fibrosis NN cord-006856-b1w25ob5 1629 12 - - HYPH cord-006856-b1w25ob5 1629 13 mediating mediate VBG cord-006856-b1w25ob5 1629 14 immigrated immigrate VBN cord-006856-b1w25ob5 1629 15 recipient recipient NN cord-006856-b1w25ob5 1629 16 - - HYPH cord-006856-b1w25ob5 1629 17 derived derive VBN cord-006856-b1w25ob5 1629 18 fibroblasts fibroblast NNS cord-006856-b1w25ob5 1629 19 in in IN cord-006856-b1w25ob5 1629 20 cardiac cardiac JJ cord-006856-b1w25ob5 1629 21 allografts allograft NNS cord-006856-b1w25ob5 1629 22 . . . cord-006856-b1w25ob5 1630 1 Furthermore furthermore RB cord-006856-b1w25ob5 1630 2 , , , cord-006856-b1w25ob5 1630 3 this this DT cord-006856-b1w25ob5 1630 4 suggests suggest VBZ cord-006856-b1w25ob5 1630 5 a a DT cord-006856-b1w25ob5 1630 6 potential potential JJ cord-006856-b1w25ob5 1630 7 , , , cord-006856-b1w25ob5 1630 8 future future JJ cord-006856-b1w25ob5 1630 9 therapeutic therapeutic JJ cord-006856-b1w25ob5 1630 10 approach approach NN cord-006856-b1w25ob5 1630 11 for for IN cord-006856-b1w25ob5 1630 12 reduction reduction NN cord-006856-b1w25ob5 1630 13 the the DT cord-006856-b1w25ob5 1630 14 cardiac cardiac JJ cord-006856-b1w25ob5 1630 15 fibrosis fibrosis NN cord-006856-b1w25ob5 1630 16 process process NN cord-006856-b1w25ob5 1630 17 . . . cord-006856-b1w25ob5 1631 1 Methods method NNS cord-006856-b1w25ob5 1631 2 . . . cord-006856-b1w25ob5 1632 1 Between between IN cord-006856-b1w25ob5 1632 2 1993 1993 CD cord-006856-b1w25ob5 1632 3 and and CC cord-006856-b1w25ob5 1632 4 1998 1998 CD cord-006856-b1w25ob5 1632 5 a a DT cord-006856-b1w25ob5 1632 6 total total NN cord-006856-b1w25ob5 1632 7 of of IN cord-006856-b1w25ob5 1632 8 32 32 CD cord-006856-b1w25ob5 1632 9 lung lung NN cord-006856-b1w25ob5 1632 10 transplants transplant NNS cord-006856-b1w25ob5 1632 11 ( ( -LRB- cord-006856-b1w25ob5 1632 12 31 31 CD cord-006856-b1w25ob5 1632 13 patients patient NNS cord-006856-b1w25ob5 1632 14 ) ) -RRB- cord-006856-b1w25ob5 1632 15 and and CC cord-006856-b1w25ob5 1632 16 six six CD cord-006856-b1w25ob5 1632 17 combined combine VBN cord-006856-b1w25ob5 1632 18 heart heart NN cord-006856-b1w25ob5 1632 19 - - HYPH cord-006856-b1w25ob5 1632 20 lung lung NN cord-006856-b1w25ob5 1632 21 transplants transplant NNS cord-006856-b1w25ob5 1632 22 were be VBD cord-006856-b1w25ob5 1632 23 performed perform VBN cord-006856-b1w25ob5 1632 24 at at IN cord-006856-b1w25ob5 1632 25 our -PRON- PRP$ cord-006856-b1w25ob5 1632 26 center center NN cord-006856-b1w25ob5 1632 27 . . . cord-006856-b1w25ob5 1633 1 Immunosuppression Immunosuppression NNP cord-006856-b1w25ob5 1633 2 consisted consist VBD cord-006856-b1w25ob5 1633 3 of of IN cord-006856-b1w25ob5 1633 4 ATG ATG NNP cord-006856-b1w25ob5 1633 5 induction induction NN cord-006856-b1w25ob5 1633 6 , , , cord-006856-b1w25ob5 1633 7 Cyclosporine Cyclosporine NNP cord-006856-b1w25ob5 1633 8 A A NNP cord-006856-b1w25ob5 1633 9 , , , cord-006856-b1w25ob5 1633 10 azathioprine azathioprine NN cord-006856-b1w25ob5 1633 11 , , , cord-006856-b1w25ob5 1633 12 and and CC cord-006856-b1w25ob5 1633 13 steroids steroid NNS cord-006856-b1w25ob5 1633 14 . . . cord-006856-b1w25ob5 1634 1 All all DT cord-006856-b1w25ob5 1634 2 patients patient NNS cord-006856-b1w25ob5 1634 3 with with IN cord-006856-b1w25ob5 1634 4 RTI RTI NNP cord-006856-b1w25ob5 1634 5 underwent undergo VBD cord-006856-b1w25ob5 1634 6 a a DT cord-006856-b1w25ob5 1634 7 meticulous meticulous JJ cord-006856-b1w25ob5 1634 8 micro micro JJ cord-006856-b1w25ob5 1634 9 - - JJ cord-006856-b1w25ob5 1634 10 biological biological JJ cord-006856-b1w25ob5 1634 11 screening screening NN cord-006856-b1w25ob5 1634 12 and and CC cord-006856-b1w25ob5 1634 13 underwent undergo VBD cord-006856-b1w25ob5 1634 14 bronchoscopy bronchoscopy RB cord-006856-b1w25ob5 1634 15 with with IN cord-006856-b1w25ob5 1634 16 bronchiolo bronchiolo JJ cord-006856-b1w25ob5 1634 17 - - HYPH cord-006856-b1w25ob5 1634 18 alveolar alveolar NN cord-006856-b1w25ob5 1634 19 lavage lavage NN cord-006856-b1w25ob5 1634 20 ( ( -LRB- cord-006856-b1w25ob5 1634 21 BAL BAL NNP cord-006856-b1w25ob5 1634 22 ) ) -RRB- cord-006856-b1w25ob5 1634 23 and and CC cord-006856-b1w25ob5 1634 24 transbronchial transbronchial JJ cord-006856-b1w25ob5 1634 25 biopsies biopsy NNS cord-006856-b1w25ob5 1634 26 ( ( -LRB- cord-006856-b1w25ob5 1634 27 TBB TBB NNP cord-006856-b1w25ob5 1634 28 ) ) -RRB- cord-006856-b1w25ob5 1634 29 . . . cord-006856-b1w25ob5 1635 1 RSV RSV NNP cord-006856-b1w25ob5 1635 2 was be VBD cord-006856-b1w25ob5 1635 3 detected detect VBN cord-006856-b1w25ob5 1635 4 from from IN cord-006856-b1w25ob5 1635 5 BAL bal NN cord-006856-b1w25ob5 1635 6 specimens specimen NNS cord-006856-b1w25ob5 1635 7 by by IN cord-006856-b1w25ob5 1635 8 an an DT cord-006856-b1w25ob5 1635 9 immunoassay immunoassay NN cord-006856-b1w25ob5 1635 10 . . . cord-006856-b1w25ob5 1636 1 Results result NNS cord-006856-b1w25ob5 1636 2 . . . cord-006856-b1w25ob5 1637 1 A a DT cord-006856-b1w25ob5 1637 2 total total NN cord-006856-b1w25ob5 1637 3 of of IN cord-006856-b1w25ob5 1637 4 five five CD cord-006856-b1w25ob5 1637 5 lung lung NN cord-006856-b1w25ob5 1637 6 recipients recipient NNS cord-006856-b1w25ob5 1637 7 ( ( -LRB- cord-006856-b1w25ob5 1637 8 31 31 CD cord-006856-b1w25ob5 1637 9 % % NN cord-006856-b1w25ob5 1637 10 of of IN cord-006856-b1w25ob5 1637 11 19 19 CD cord-006856-b1w25ob5 1637 12 survivors survivor NNS cord-006856-b1w25ob5 1637 13 ) ) -RRB- cord-006856-b1w25ob5 1637 14 and and CC cord-006856-b1w25ob5 1637 15 one one CD cord-006856-b1w25ob5 1637 16 of of IN cord-006856-b1w25ob5 1637 17 the the DT cord-006856-b1w25ob5 1637 18 two two CD cord-006856-b1w25ob5 1637 19 alive alive JJ cord-006856-b1w25ob5 1637 20 heart heart NN cord-006856-b1w25ob5 1637 21 - - HYPH cord-006856-b1w25ob5 1637 22 lung lung NN cord-006856-b1w25ob5 1637 23 recipients recipient NNS cord-006856-b1w25ob5 1637 24 developed develop VBD cord-006856-b1w25ob5 1637 25 RSV RSV NNP cord-006856-b1w25ob5 1637 26 infection infection NN cord-006856-b1w25ob5 1637 27 of of IN cord-006856-b1w25ob5 1637 28 the the DT cord-006856-b1w25ob5 1637 29 lung lung NN cord-006856-b1w25ob5 1637 30 allograft allograft NN cord-006856-b1w25ob5 1637 31 . . . cord-006856-b1w25ob5 1638 1 All all DT cord-006856-b1w25ob5 1638 2 cases case NNS cord-006856-b1w25ob5 1638 3 were be VBD cord-006856-b1w25ob5 1638 4 observed observe VBN cord-006856-b1w25ob5 1638 5 during during IN cord-006856-b1w25ob5 1638 6 an an DT cord-006856-b1w25ob5 1638 7 RSV RSV NNP cord-006856-b1w25ob5 1638 8 epidemic epidemic NN cord-006856-b1w25ob5 1638 9 in in IN cord-006856-b1w25ob5 1638 10 children child NNS cord-006856-b1w25ob5 1638 11 in in IN cord-006856-b1w25ob5 1638 12 the the DT cord-006856-b1w25ob5 1638 13 area area NN cord-006856-b1w25ob5 1638 14 between between IN cord-006856-b1w25ob5 1638 15 October October NNP cord-006856-b1w25ob5 1638 16 1998 1998 CD cord-006856-b1w25ob5 1638 17 and and CC cord-006856-b1w25ob5 1638 18 May May NNP cord-006856-b1w25ob5 1638 19 1999 1999 CD cord-006856-b1w25ob5 1638 20 . . . cord-006856-b1w25ob5 1639 1 The the DT cord-006856-b1w25ob5 1639 2 patients patient NNS cord-006856-b1w25ob5 1639 3 were be VBD cord-006856-b1w25ob5 1639 4 47 47 CD cord-006856-b1w25ob5 1639 5 - - SYM cord-006856-b1w25ob5 1639 6 55 55 CD cord-006856-b1w25ob5 1639 7 years year NNS cord-006856-b1w25ob5 1639 8 old old JJ cord-006856-b1w25ob5 1639 9 , , , cord-006856-b1w25ob5 1639 10 all all DT cord-006856-b1w25ob5 1639 11 were be VBD cord-006856-b1w25ob5 1639 12 females female NNS cord-006856-b1w25ob5 1639 13 . . . cord-006856-b1w25ob5 1640 1 One one CD cord-006856-b1w25ob5 1640 2 patient patient NN cord-006856-b1w25ob5 1640 3 experienced experience VBD cord-006856-b1w25ob5 1640 4 two two CD cord-006856-b1w25ob5 1640 5 episodes episode NNS cord-006856-b1w25ob5 1640 6 . . . cord-006856-b1w25ob5 1641 1 Onset onset NN cord-006856-b1w25ob5 1641 2 of of IN cord-006856-b1w25ob5 1641 3 RSV RSV NNP cord-006856-b1w25ob5 1641 4 was be VBD cord-006856-b1w25ob5 1641 5 median median JJ cord-006856-b1w25ob5 1641 6 3 3 CD cord-006856-b1w25ob5 1642 1 ( ( -LRB- cord-006856-b1w25ob5 1642 2 range range NN cord-006856-b1w25ob5 1642 3 , , , cord-006856-b1w25ob5 1642 4 4 4 CD cord-006856-b1w25ob5 1642 5 - - SYM cord-006856-b1w25ob5 1642 6 29 29 CD cord-006856-b1w25ob5 1642 7 ) ) -RRB- cord-006856-b1w25ob5 1642 8 months month NNS cord-006856-b1w25ob5 1642 9 post post NN cord-006856-b1w25ob5 1642 10 transplant transplant NN cord-006856-b1w25ob5 1642 11 . . . cord-006856-b1w25ob5 1643 1 Clinical clinical JJ cord-006856-b1w25ob5 1643 2 symptoms symptom NNS cord-006856-b1w25ob5 1643 3 included include VBD cord-006856-b1w25ob5 1643 4 cough cough NN cord-006856-b1w25ob5 1643 5 ( ( -LRB- cord-006856-b1w25ob5 1643 6 6 6 CD cord-006856-b1w25ob5 1643 7 of of IN cord-006856-b1w25ob5 1643 8 7 7 CD cord-006856-b1w25ob5 1643 9 ) ) -RRB- cord-006856-b1w25ob5 1643 10 , , , cord-006856-b1w25ob5 1643 11 rhinitis rhinitis NN cord-006856-b1w25ob5 1643 12 ( ( -LRB- cord-006856-b1w25ob5 1643 13 6 6 CD cord-006856-b1w25ob5 1643 14 of of IN cord-006856-b1w25ob5 1643 15 7 7 CD cord-006856-b1w25ob5 1643 16 ) ) -RRB- cord-006856-b1w25ob5 1643 17 , , , cord-006856-b1w25ob5 1643 18 and and CC cord-006856-b1w25ob5 1643 19 fever fever NN cord-006856-b1w25ob5 1643 20 ( ( -LRB- cord-006856-b1w25ob5 1643 21 4 4 CD cord-006856-b1w25ob5 1643 22 of of IN cord-006856-b1w25ob5 1643 23 7 7 CD cord-006856-b1w25ob5 1643 24 ) ) -RRB- cord-006856-b1w25ob5 1643 25 . . . cord-006856-b1w25ob5 1644 1 Deterioration deterioration NN cord-006856-b1w25ob5 1644 2 of of IN cord-006856-b1w25ob5 1644 3 lung lung NN cord-006856-b1w25ob5 1644 4 function function NN cord-006856-b1w25ob5 1644 5 occurred occur VBD cord-006856-b1w25ob5 1644 6 in in IN cord-006856-b1w25ob5 1644 7 six six CD cord-006856-b1w25ob5 1644 8 of of IN cord-006856-b1w25ob5 1644 9 the the DT cord-006856-b1w25ob5 1644 10 seven seven CD cord-006856-b1w25ob5 1644 11 episodes episode NNS cord-006856-b1w25ob5 1644 12 with with IN cord-006856-b1w25ob5 1644 13 one one CD cord-006856-b1w25ob5 1644 14 deteriorating deteriorate VBG cord-006856-b1w25ob5 1644 15 to to IN cord-006856-b1w25ob5 1644 16 respiratory respiratory JJ cord-006856-b1w25ob5 1644 17 failure failure NN cord-006856-b1w25ob5 1644 18 requiring require VBG cord-006856-b1w25ob5 1644 19 ventilator ventilator NN cord-006856-b1w25ob5 1644 20 support support NN cord-006856-b1w25ob5 1644 21 . . . cord-006856-b1w25ob5 1645 1 Two two CD cord-006856-b1w25ob5 1645 2 individuals individual NNS cord-006856-b1w25ob5 1645 3 developed develop VBD cord-006856-b1w25ob5 1645 4 pulmonary pulmonary NN cord-006856-b1w25ob5 1645 5 infiltrates infiltrate NNS cord-006856-b1w25ob5 1645 6 . . . cord-006856-b1w25ob5 1646 1 In in IN cord-006856-b1w25ob5 1646 2 all all DT cord-006856-b1w25ob5 1646 3 patients patient NNS cord-006856-b1w25ob5 1646 4 , , , cord-006856-b1w25ob5 1646 5 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1646 6 was be VBD cord-006856-b1w25ob5 1646 7 significantly significantly RB cord-006856-b1w25ob5 1646 8 tapered taper VBN cord-006856-b1w25ob5 1646 9 , , , cord-006856-b1w25ob5 1646 10 86 86 CD cord-006856-b1w25ob5 1646 11 % % NN cord-006856-b1w25ob5 1646 12 required require VBN cord-006856-b1w25ob5 1646 13 hospitalization hospitalization NN cord-006856-b1w25ob5 1646 14 and and CC cord-006856-b1w25ob5 1646 15 antibiotic antibiotic JJ cord-006856-b1w25ob5 1646 16 therapy therapy NN cord-006856-b1w25ob5 1646 17 . . . cord-006856-b1w25ob5 1647 1 The the DT cord-006856-b1w25ob5 1647 2 patient patient NN cord-006856-b1w25ob5 1647 3 with with IN cord-006856-b1w25ob5 1647 4 RSV RSV NNP cord-006856-b1w25ob5 1647 5 recurrence recurrence NN cord-006856-b1w25ob5 1647 6 received receive VBD cord-006856-b1w25ob5 1647 7 inhalative inhalative JJ cord-006856-b1w25ob5 1647 8 ribavirin ribavirin NNP cord-006856-b1w25ob5 1647 9 therapy therapy NN cord-006856-b1w25ob5 1647 10 during during IN cord-006856-b1w25ob5 1647 11 the the DT cord-006856-b1w25ob5 1647 12 second second JJ cord-006856-b1w25ob5 1647 13 episode episode NN cord-006856-b1w25ob5 1647 14 . . . cord-006856-b1w25ob5 1648 1 All all DT cord-006856-b1w25ob5 1648 2 patients patient NNS cord-006856-b1w25ob5 1648 3 recovered recover VBD cord-006856-b1w25ob5 1648 4 and and CC cord-006856-b1w25ob5 1648 5 survival survival NN cord-006856-b1w25ob5 1648 6 of of IN cord-006856-b1w25ob5 1648 7 this this DT cord-006856-b1w25ob5 1648 8 cohort cohort NN cord-006856-b1w25ob5 1648 9 was be VBD cord-006856-b1w25ob5 1648 10 86 86 CD cord-006856-b1w25ob5 1648 11 % % NN cord-006856-b1w25ob5 1648 12 after after IN cord-006856-b1w25ob5 1648 13 1 1 CD cord-006856-b1w25ob5 1648 14 year year NN cord-006856-b1w25ob5 1648 15 and and CC cord-006856-b1w25ob5 1648 16 72 72 CD cord-006856-b1w25ob5 1648 17 % % NN cord-006856-b1w25ob5 1648 18 at at IN cord-006856-b1w25ob5 1648 19 4 4 CD cord-006856-b1w25ob5 1648 20 years year NNS cord-006856-b1w25ob5 1648 21 after after IN cord-006856-b1w25ob5 1648 22 RSV RSV NNP cord-006856-b1w25ob5 1648 23 infection infection NN cord-006856-b1w25ob5 1648 24 . . . cord-006856-b1w25ob5 1649 1 None none NN cord-006856-b1w25ob5 1649 2 of of IN cord-006856-b1w25ob5 1649 3 the the DT cord-006856-b1w25ob5 1649 4 patients patient NNS cord-006856-b1w25ob5 1649 5 developed develop VBD cord-006856-b1w25ob5 1649 6 bronchiolitis bronchiolitis NNP cord-006856-b1w25ob5 1649 7 obliterans obliterans NNP cord-006856-b1w25ob5 1649 8 syndrome syndrome NNP cord-006856-b1w25ob5 1649 9 ( ( -LRB- cord-006856-b1w25ob5 1649 10 BOS BOS NNP cord-006856-b1w25ob5 1649 11 ) ) -RRB- cord-006856-b1w25ob5 1649 12 or or CC cord-006856-b1w25ob5 1649 13 rejection rejection NN cord-006856-b1w25ob5 1649 14 during during IN cord-006856-b1w25ob5 1649 15 follow follow NN cord-006856-b1w25ob5 1649 16 - - HYPH cord-006856-b1w25ob5 1649 17 up up NN cord-006856-b1w25ob5 1649 18 . . . cord-006856-b1w25ob5 1650 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1650 2 . . . cord-006856-b1w25ob5 1651 1 RSV RSV NNP cord-006856-b1w25ob5 1651 2 is be VBZ cord-006856-b1w25ob5 1651 3 a a DT cord-006856-b1w25ob5 1651 4 severe severe JJ cord-006856-b1w25ob5 1651 5 but but CC cord-006856-b1w25ob5 1651 6 benign benign JJ cord-006856-b1w25ob5 1651 7 complication complication NN cord-006856-b1w25ob5 1651 8 following follow VBG cord-006856-b1w25ob5 1651 9 lung lung NN cord-006856-b1w25ob5 1651 10 transplantation transplantation NN cord-006856-b1w25ob5 1651 11 with with IN cord-006856-b1w25ob5 1651 12 a a DT cord-006856-b1w25ob5 1651 13 wide wide JJ cord-006856-b1w25ob5 1651 14 range range NN cord-006856-b1w25ob5 1651 15 of of IN cord-006856-b1w25ob5 1651 16 clinical clinical JJ cord-006856-b1w25ob5 1651 17 presentations presentation NNS cord-006856-b1w25ob5 1651 18 . . . cord-006856-b1w25ob5 1652 1 Routine routine JJ cord-006856-b1w25ob5 1652 2 use use NN cord-006856-b1w25ob5 1652 3 of of IN cord-006856-b1w25ob5 1652 4 antiviral antiviral JJ cord-006856-b1w25ob5 1652 5 treatment treatment NN cord-006856-b1w25ob5 1652 6 is be VBZ cord-006856-b1w25ob5 1652 7 not not RB cord-006856-b1w25ob5 1652 8 necessary necessary JJ cord-006856-b1w25ob5 1652 9 ; ; : cord-006856-b1w25ob5 1652 10 however however RB cord-006856-b1w25ob5 1652 11 , , , cord-006856-b1w25ob5 1652 12 reduction reduction NN cord-006856-b1w25ob5 1652 13 in in IN cord-006856-b1w25ob5 1652 14 the the DT cord-006856-b1w25ob5 1652 15 level level NN cord-006856-b1w25ob5 1652 16 of of IN cord-006856-b1w25ob5 1652 17 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1652 18 is be VBZ cord-006856-b1w25ob5 1652 19 required require VBN cord-006856-b1w25ob5 1652 20 . . . cord-006856-b1w25ob5 1653 1 No no DT cord-006856-b1w25ob5 1653 2 long long JJ cord-006856-b1w25ob5 1653 3 - - HYPH cord-006856-b1w25ob5 1653 4 term term NN cord-006856-b1w25ob5 1653 5 effects effect NNS cord-006856-b1w25ob5 1653 6 were be VBD cord-006856-b1w25ob5 1653 7 observed observe VBN cord-006856-b1w25ob5 1653 8 in in IN cord-006856-b1w25ob5 1653 9 this this DT cord-006856-b1w25ob5 1653 10 cohort cohort NN cord-006856-b1w25ob5 1653 11 . . . cord-006856-b1w25ob5 1654 1 A. A. NNP cord-006856-b1w25ob5 1654 2 Stamatelopoulos Stamatelopoulos NNP cord-006856-b1w25ob5 1654 3 1,2 1,2 CD cord-006856-b1w25ob5 1654 4 , , , cord-006856-b1w25ob5 1654 5 S. S. NNP cord-006856-b1w25ob5 1654 6 Guth Guth NNP cord-006856-b1w25ob5 1654 7 2 2 CD cord-006856-b1w25ob5 1654 8 , , , cord-006856-b1w25ob5 1654 9 A. A. NNP cord-006856-b1w25ob5 1654 10 Abrahim Abrahim NNP cord-006856-b1w25ob5 1654 11 2 2 CD cord-006856-b1w25ob5 1654 12 , , , cord-006856-b1w25ob5 1654 13 G. G. NNP cord-006856-b1w25ob5 1654 14 M. M. NNP cord-006856-b1w25ob5 1654 15 Marta Marta NNP cord-006856-b1w25ob5 1654 16 2 2 CD cord-006856-b1w25ob5 1654 17 , , , cord-006856-b1w25ob5 1654 18 L. L. NNP cord-006856-b1w25ob5 1654 19 Tsourelis Tsourelis NNP cord-006856-b1w25ob5 1654 20 3 3 CD cord-006856-b1w25ob5 1654 21 , , , cord-006856-b1w25ob5 1654 22 P. P. NNP cord-006856-b1w25ob5 1654 23 Jaksch Jaksch NNP cord-006856-b1w25ob5 1654 24 2 2 CD cord-006856-b1w25ob5 1654 25 , , , cord-006856-b1w25ob5 1654 26 C. C. NNP cord-006856-b1w25ob5 1654 27 Konaris Konaris NNP cord-006856-b1w25ob5 1654 28 4 4 CD cord-006856-b1w25ob5 1654 29 , , , cord-006856-b1w25ob5 1654 30 S.Taghavi S.Taghavi NNP cord-006856-b1w25ob5 1654 31 2 2 CD cord-006856-b1w25ob5 1654 32 , , , cord-006856-b1w25ob5 1654 33 W. W. NNP cord-006856-b1w25ob5 1654 34 Klepetko Klepetko NNP cord-006856-b1w25ob5 1654 35 2 2 CD cord-006856-b1w25ob5 1654 36 due due JJ cord-006856-b1w25ob5 1654 37 to to IN cord-006856-b1w25ob5 1654 38 CNI CNI NNP cord-006856-b1w25ob5 1654 39 nephrotoxicity nephrotoxicity NN cord-006856-b1w25ob5 1654 40 in in IN cord-006856-b1w25ob5 1654 41 a a DT cord-006856-b1w25ob5 1654 42 substantial substantial JJ cord-006856-b1w25ob5 1654 43 number number NN cord-006856-b1w25ob5 1654 44 of of IN cord-006856-b1w25ob5 1654 45 NTX NTX NNP cord-006856-b1w25ob5 1654 46 patients patient NNS cord-006856-b1w25ob5 1654 47 . . . cord-006856-b1w25ob5 1655 1 We -PRON- PRP cord-006856-b1w25ob5 1655 2 therefore therefore RB cord-006856-b1w25ob5 1655 3 studied study VBD cord-006856-b1w25ob5 1655 4 the the DT cord-006856-b1w25ob5 1655 5 effects effect NNS cord-006856-b1w25ob5 1655 6 of of IN cord-006856-b1w25ob5 1655 7 a a DT cord-006856-b1w25ob5 1655 8 switch switch NN cord-006856-b1w25ob5 1655 9 from from IN cord-006856-b1w25ob5 1655 10 a a DT cord-006856-b1w25ob5 1655 11 CNI CNI NNP cord-006856-b1w25ob5 1655 12 regimen regimen NN cord-006856-b1w25ob5 1655 13 ( ( -LRB- cord-006856-b1w25ob5 1655 14 CNI CNI NNP cord-006856-b1w25ob5 1655 15 + + SYM cord-006856-b1w25ob5 1655 16 MPA MPA NNP cord-006856-b1w25ob5 1655 17 + + CC cord-006856-b1w25ob5 1655 18 P p NN cord-006856-b1w25ob5 1655 19 ) ) -RRB- cord-006856-b1w25ob5 1655 20 to to IN cord-006856-b1w25ob5 1655 21 a a DT cord-006856-b1w25ob5 1655 22 dual dual JJ cord-006856-b1w25ob5 1655 23 regimen regimen NN cord-006856-b1w25ob5 1655 24 of of IN cord-006856-b1w25ob5 1655 25 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1655 26 ( ( -LRB- cord-006856-b1w25ob5 1655 27 SRL SRL NNP cord-006856-b1w25ob5 1655 28 ) ) -RRB- cord-006856-b1w25ob5 1655 29 plus plus CC cord-006856-b1w25ob5 1655 30 Prednisolon Prednisolon NNP cord-006856-b1w25ob5 1655 31 ( ( -LRB- cord-006856-b1w25ob5 1655 32 P p NN cord-006856-b1w25ob5 1655 33 ) ) -RRB- cord-006856-b1w25ob5 1655 34 in in IN cord-006856-b1w25ob5 1655 35 26 26 CD cord-006856-b1w25ob5 1655 36 pts pt NNS cord-006856-b1w25ob5 1655 37 with with IN cord-006856-b1w25ob5 1655 38 moderately moderately RB cord-006856-b1w25ob5 1655 39 impaired impaired JJ cord-006856-b1w25ob5 1655 40 kidney kidney NN cord-006856-b1w25ob5 1655 41 function function NN cord-006856-b1w25ob5 1655 42 ( ( -LRB- cord-006856-b1w25ob5 1655 43 S S NNP cord-006856-b1w25ob5 1655 44 - - HYPH cord-006856-b1w25ob5 1655 45 Crea Crea NNP cord-006856-b1w25ob5 1655 46 , , , cord-006856-b1w25ob5 1655 47 1.5 1.5 CD cord-006856-b1w25ob5 1655 48 + + SYM cord-006856-b1w25ob5 1655 49 0.4 0.4 CD cord-006856-b1w25ob5 1655 50 mg% mg% CD cord-006856-b1w25ob5 1655 51 ) ) -RRB- cord-006856-b1w25ob5 1655 52 due due IN cord-006856-b1w25ob5 1655 53 to to IN cord-006856-b1w25ob5 1655 54 either either CC cord-006856-b1w25ob5 1655 55 CNI CNI NNP cord-006856-b1w25ob5 1655 56 toxicity toxicity NN cord-006856-b1w25ob5 1655 57 or or CC cord-006856-b1w25ob5 1655 58 clinical clinical JJ cord-006856-b1w25ob5 1655 59 evidence evidence NN cord-006856-b1w25ob5 1655 60 for for IN cord-006856-b1w25ob5 1655 61 chronic chronic JJ cord-006856-b1w25ob5 1655 62 allograft allograft NN cord-006856-b1w25ob5 1655 63 disease disease NN cord-006856-b1w25ob5 1655 64 . . . cord-006856-b1w25ob5 1656 1 13 13 CD cord-006856-b1w25ob5 1656 2 pts pt NNS cord-006856-b1w25ob5 1656 3 received receive VBD cord-006856-b1w25ob5 1656 4 regimen regimen NN cord-006856-b1w25ob5 1656 5 1 1 CD cord-006856-b1w25ob5 1656 6 consisting consist VBG cord-006856-b1w25ob5 1656 7 of of IN cord-006856-b1w25ob5 1656 8 SRL SRL NNP cord-006856-b1w25ob5 1656 9 12 12 CD cord-006856-b1w25ob5 1656 10 mg mg NNP cord-006856-b1w25ob5 1656 11 dosage dosage NN cord-006856-b1w25ob5 1656 12 on on IN cord-006856-b1w25ob5 1656 13 day day NN cord-006856-b1w25ob5 1656 14 1 1 CD cord-006856-b1w25ob5 1656 15 and and CC cord-006856-b1w25ob5 1656 16 from from IN cord-006856-b1w25ob5 1656 17 days day NNS cord-006856-b1w25ob5 1656 18 2 2 CD cord-006856-b1w25ob5 1656 19 to to IN cord-006856-b1w25ob5 1656 20 5 5 CD cord-006856-b1w25ob5 1656 21 SRL SRL NNP cord-006856-b1w25ob5 1656 22 4 4 CD cord-006856-b1w25ob5 1656 23 mg mg NNP cord-006856-b1w25ob5 1656 24 plus plus CC cord-006856-b1w25ob5 1656 25 CSA CSA NNP cord-006856-b1w25ob5 1656 26 at at IN cord-006856-b1w25ob5 1656 27 half half NN cord-006856-b1w25ob5 1656 28 of of IN cord-006856-b1w25ob5 1656 29 maintenance maintenance NN cord-006856-b1w25ob5 1656 30 dosage dosage NN cord-006856-b1w25ob5 1656 31 . . . cord-006856-b1w25ob5 1657 1 From from IN cord-006856-b1w25ob5 1657 2 day day NN cord-006856-b1w25ob5 1657 3 6 6 CD cord-006856-b1w25ob5 1657 4 on on IN cord-006856-b1w25ob5 1657 5 , , , cord-006856-b1w25ob5 1657 6 pts pts NNP cord-006856-b1w25ob5 1657 7 received receive VBD cord-006856-b1w25ob5 1657 8 SRL SRL NNP cord-006856-b1w25ob5 1657 9 8 8 CD cord-006856-b1w25ob5 1657 10 mg mg NNP cord-006856-b1w25ob5 1657 11 and and CC cord-006856-b1w25ob5 1657 12 CSA CSA NNP cord-006856-b1w25ob5 1657 13 was be VBD cord-006856-b1w25ob5 1657 14 withdrawn withdraw VBN cord-006856-b1w25ob5 1657 15 . . . cord-006856-b1w25ob5 1658 1 MPA MPA NNP cord-006856-b1w25ob5 1658 2 or or CC cord-006856-b1w25ob5 1658 3 AZA AZA NNP cord-006856-b1w25ob5 1658 4 dose dose NN cord-006856-b1w25ob5 1658 5 was be VBD cord-006856-b1w25ob5 1658 6 continued continue VBN cord-006856-b1w25ob5 1658 7 halfed halfe VBN cord-006856-b1w25ob5 1658 8 for for IN cord-006856-b1w25ob5 1658 9 4 4 CD cord-006856-b1w25ob5 1658 10 to to TO cord-006856-b1w25ob5 1658 11 6 6 CD cord-006856-b1w25ob5 1658 12 weeks week NNS cord-006856-b1w25ob5 1658 13 . . . cord-006856-b1w25ob5 1659 1 P p NN cord-006856-b1w25ob5 1659 2 was be VBD cord-006856-b1w25ob5 1659 3 kept keep VBN cord-006856-b1w25ob5 1659 4 constant constant JJ cord-006856-b1w25ob5 1659 5 . . . cord-006856-b1w25ob5 1660 1 Target target VB cord-006856-b1w25ob5 1660 2 level level NN cord-006856-b1w25ob5 1660 3 for for IN cord-006856-b1w25ob5 1660 4 SRL SRL NNP cord-006856-b1w25ob5 1660 5 was be VBD cord-006856-b1w25ob5 1660 6 12 12 CD cord-006856-b1w25ob5 1660 7 - - SYM cord-006856-b1w25ob5 1660 8 20 20 CD cord-006856-b1w25ob5 1660 9 ng ng NN cord-006856-b1w25ob5 1660 10 / / SYM cord-006856-b1w25ob5 1660 11 ml ml NN cord-006856-b1w25ob5 1660 12 . . . cord-006856-b1w25ob5 1661 1 Another another DT cord-006856-b1w25ob5 1661 2 13 13 CD cord-006856-b1w25ob5 1661 3 pats pat NNS cord-006856-b1w25ob5 1661 4 received receive VBD cord-006856-b1w25ob5 1661 5 regimen regimen NN cord-006856-b1w25ob5 1661 6 2 2 CD cord-006856-b1w25ob5 1661 7 consisting consist VBG cord-006856-b1w25ob5 1661 8 of of IN cord-006856-b1w25ob5 1661 9 SRL SRL NNP cord-006856-b1w25ob5 1661 10 12 12 CD cord-006856-b1w25ob5 1661 11 mg mg NNP cord-006856-b1w25ob5 1661 12 and and CC cord-006856-b1w25ob5 1661 13 CSA CSA NNP cord-006856-b1w25ob5 1661 14 withdrawal withdrawal NN cord-006856-b1w25ob5 1661 15 on on IN cord-006856-b1w25ob5 1661 16 day day NN cord-006856-b1w25ob5 1661 17 1 1 CD cord-006856-b1w25ob5 1661 18 and and CC cord-006856-b1w25ob5 1661 19 from from IN cord-006856-b1w25ob5 1661 20 days day NNS cord-006856-b1w25ob5 1661 21 2 2 CD cord-006856-b1w25ob5 1661 22 to to IN cord-006856-b1w25ob5 1661 23 6 6 CD cord-006856-b1w25ob5 1661 24 SRL SRL NNP cord-006856-b1w25ob5 1661 25 6 6 CD cord-006856-b1w25ob5 1661 26 mg mg NNP cord-006856-b1w25ob5 1661 27 was be VBD cord-006856-b1w25ob5 1661 28 administered administer VBN cord-006856-b1w25ob5 1661 29 for for IN cord-006856-b1w25ob5 1661 30 a a DT cord-006856-b1w25ob5 1661 31 target target NN cord-006856-b1w25ob5 1661 32 level level NN cord-006856-b1w25ob5 1661 33 of of IN cord-006856-b1w25ob5 1661 34 7 7 CD cord-006856-b1w25ob5 1661 35 to to TO cord-006856-b1w25ob5 1661 36 10 10 CD cord-006856-b1w25ob5 1661 37 ng ng NN cord-006856-b1w25ob5 1661 38 / / SYM cord-006856-b1w25ob5 1661 39 ml ml NN cord-006856-b1w25ob5 1661 40 . . . cord-006856-b1w25ob5 1662 1 MPA MPA NNP cord-006856-b1w25ob5 1662 2 or or CC cord-006856-b1w25ob5 1662 3 AZA AZA NNP cord-006856-b1w25ob5 1662 4 were be VBD cord-006856-b1w25ob5 1662 5 continued continue VBN cord-006856-b1w25ob5 1662 6 halfed halfe VBN cord-006856-b1w25ob5 1662 7 for for IN cord-006856-b1w25ob5 1662 8 4 4 CD cord-006856-b1w25ob5 1662 9 to to TO cord-006856-b1w25ob5 1662 10 6 6 CD cord-006856-b1w25ob5 1662 11 weeks week NNS cord-006856-b1w25ob5 1662 12 , , , cord-006856-b1w25ob5 1662 13 P p NN cord-006856-b1w25ob5 1662 14 was be VBD cord-006856-b1w25ob5 1662 15 kept keep VBN cord-006856-b1w25ob5 1662 16 constant constant JJ cord-006856-b1w25ob5 1662 17 . . . cord-006856-b1w25ob5 1663 1 With with IN cord-006856-b1w25ob5 1663 2 regimen regimen NN cord-006856-b1w25ob5 1663 3 1 1 CD cord-006856-b1w25ob5 1663 4 there there EX cord-006856-b1w25ob5 1663 5 were be VBD cord-006856-b1w25ob5 1663 6 6 6 CD cord-006856-b1w25ob5 1663 7 dropouts dropout NNS cord-006856-b1w25ob5 1663 8 due due JJ cord-006856-b1w25ob5 1663 9 to to IN cord-006856-b1w25ob5 1663 10 adverse adverse JJ cord-006856-b1w25ob5 1663 11 events event NNS cord-006856-b1w25ob5 1663 12 , , , cord-006856-b1w25ob5 1663 13 whereas whereas IN cord-006856-b1w25ob5 1663 14 with with IN cord-006856-b1w25ob5 1663 15 regimen regimen NN cord-006856-b1w25ob5 1663 16 2 2 CD cord-006856-b1w25ob5 1663 17 only only RB cord-006856-b1w25ob5 1663 18 2 2 CD cord-006856-b1w25ob5 1663 19 dropouts dropout NNS cord-006856-b1w25ob5 1663 20 occurred occur VBD cord-006856-b1w25ob5 1663 21 . . . cord-006856-b1w25ob5 1664 1 45 45 CD cord-006856-b1w25ob5 1664 2 % % NN cord-006856-b1w25ob5 1664 3 of of IN cord-006856-b1w25ob5 1664 4 the the DT cord-006856-b1w25ob5 1664 5 patients patient NNS cord-006856-b1w25ob5 1664 6 showed show VBD cord-006856-b1w25ob5 1664 7 a a DT cord-006856-b1w25ob5 1664 8 decrease decrease NN cord-006856-b1w25ob5 1664 9 of of IN cord-006856-b1w25ob5 1664 10 S S NNP cord-006856-b1w25ob5 1664 11 - - HYPH cord-006856-b1w25ob5 1664 12 Crea Crea NNP cord-006856-b1w25ob5 1664 13 after after IN cord-006856-b1w25ob5 1664 14 2-year 2-year CD cord-006856-b1w25ob5 1664 15 observation observation NN cord-006856-b1w25ob5 1664 16 period period NN cord-006856-b1w25ob5 1664 17 , , , cord-006856-b1w25ob5 1664 18 20 20 CD cord-006856-b1w25ob5 1664 19 % % NN cord-006856-b1w25ob5 1664 20 were be VBD cord-006856-b1w25ob5 1664 21 unchanged unchanged JJ cord-006856-b1w25ob5 1664 22 and and CC cord-006856-b1w25ob5 1664 23 only only RB cord-006856-b1w25ob5 1664 24 25 25 CD cord-006856-b1w25ob5 1664 25 % % NN cord-006856-b1w25ob5 1664 26 showed show VBD cord-006856-b1w25ob5 1664 27 an an DT cord-006856-b1w25ob5 1664 28 increase increase NN cord-006856-b1w25ob5 1664 29 . . . cord-006856-b1w25ob5 1665 1 Overall overall RB cord-006856-b1w25ob5 1665 2 , , , cord-006856-b1w25ob5 1665 3 there there EX cord-006856-b1w25ob5 1665 4 was be VBD cord-006856-b1w25ob5 1665 5 a a DT cord-006856-b1w25ob5 1665 6 slight slight JJ cord-006856-b1w25ob5 1665 7 but but CC cord-006856-b1w25ob5 1665 8 significant significant JJ cord-006856-b1w25ob5 1665 9 increase increase NN cord-006856-b1w25ob5 1665 10 of of IN cord-006856-b1w25ob5 1665 11 cholesterol cholesterol NN cord-006856-b1w25ob5 1665 12 and and CC cord-006856-b1w25ob5 1665 13 triglycerides triglyceride NNS cord-006856-b1w25ob5 1665 14 , , , cord-006856-b1w25ob5 1665 15 whereas whereas IN cord-006856-b1w25ob5 1665 16 other other JJ cord-006856-b1w25ob5 1665 17 parameters parameter NNS cord-006856-b1w25ob5 1665 18 were be VBD cord-006856-b1w25ob5 1665 19 unchanged unchanged JJ cord-006856-b1w25ob5 1665 20 . . . cord-006856-b1w25ob5 1666 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1666 2 . . . cord-006856-b1w25ob5 1667 1 Switch switch VB cord-006856-b1w25ob5 1667 2 from from IN cord-006856-b1w25ob5 1667 3 CNI CNI NNP cord-006856-b1w25ob5 1667 4 containing contain VBG cord-006856-b1w25ob5 1667 5 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1667 6 to to IN cord-006856-b1w25ob5 1667 7 a a DT cord-006856-b1w25ob5 1667 8 dual dual JJ cord-006856-b1w25ob5 1667 9 regimen regimen NN cord-006856-b1w25ob5 1667 10 of of IN cord-006856-b1w25ob5 1667 11 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1667 12 plus plus CC cord-006856-b1w25ob5 1667 13 Prednisolon Prednisolon NNP cord-006856-b1w25ob5 1667 14 results result VBZ cord-006856-b1w25ob5 1667 15 in in IN cord-006856-b1w25ob5 1667 16 an an DT cord-006856-b1w25ob5 1667 17 improved improved JJ cord-006856-b1w25ob5 1667 18 kidney kidney NN cord-006856-b1w25ob5 1667 19 function function NN cord-006856-b1w25ob5 1667 20 after after IN cord-006856-b1w25ob5 1667 21 2 2 CD cord-006856-b1w25ob5 1667 22 years year NNS cord-006856-b1w25ob5 1667 23 in in IN cord-006856-b1w25ob5 1667 24 the the DT cord-006856-b1w25ob5 1667 25 majority majority NN cord-006856-b1w25ob5 1667 26 of of IN cord-006856-b1w25ob5 1667 27 pts pt NNS cord-006856-b1w25ob5 1667 28 . . . cord-006856-b1w25ob5 1668 1 A a DT cord-006856-b1w25ob5 1668 2 regimen regimen NN cord-006856-b1w25ob5 1668 3 of of IN cord-006856-b1w25ob5 1668 4 sirolimus sirolimus NN cord-006856-b1w25ob5 1668 5 with with IN cord-006856-b1w25ob5 1668 6 target target NN cord-006856-b1w25ob5 1668 7 levels level NNS cord-006856-b1w25ob5 1668 8 of of IN cord-006856-b1w25ob5 1668 9 12 12 CD cord-006856-b1w25ob5 1668 10 to to TO cord-006856-b1w25ob5 1668 11 20 20 CD cord-006856-b1w25ob5 1668 12 ng ng NN cord-006856-b1w25ob5 1668 13 / / SYM cord-006856-b1w25ob5 1668 14 ml ml NN cord-006856-b1w25ob5 1668 15 and and CC cord-006856-b1w25ob5 1668 16 an an DT cord-006856-b1w25ob5 1668 17 overlap overlap NN cord-006856-b1w25ob5 1668 18 of of IN cord-006856-b1w25ob5 1668 19 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1668 20 shows show VBZ cord-006856-b1w25ob5 1668 21 a a DT cord-006856-b1w25ob5 1668 22 high high JJ cord-006856-b1w25ob5 1668 23 rate rate NN cord-006856-b1w25ob5 1668 24 of of IN cord-006856-b1w25ob5 1668 25 adverse adverse JJ cord-006856-b1w25ob5 1668 26 events event NNS cord-006856-b1w25ob5 1668 27 and and CC cord-006856-b1w25ob5 1668 28 is be VBZ cord-006856-b1w25ob5 1668 29 associated associate VBN cord-006856-b1w25ob5 1668 30 with with IN cord-006856-b1w25ob5 1668 31 a a DT cord-006856-b1w25ob5 1668 32 3-fold 3-fold CD cord-006856-b1w25ob5 1668 33 dropout dropout NN cord-006856-b1w25ob5 1668 34 rate rate NN cord-006856-b1w25ob5 1668 35 as as IN cord-006856-b1w25ob5 1668 36 compared compare VBN cord-006856-b1w25ob5 1668 37 to to IN cord-006856-b1w25ob5 1668 38 a a DT cord-006856-b1w25ob5 1668 39 regimen regimen NN cord-006856-b1w25ob5 1668 40 with with IN cord-006856-b1w25ob5 1668 41 a a DT cord-006856-b1w25ob5 1668 42 target target NN cord-006856-b1w25ob5 1668 43 level level NN cord-006856-b1w25ob5 1668 44 of of IN cord-006856-b1w25ob5 1668 45 7 7 CD cord-006856-b1w25ob5 1668 46 - - SYM cord-006856-b1w25ob5 1668 47 10 10 CD cord-006856-b1w25ob5 1668 48 ng ng NN cord-006856-b1w25ob5 1668 49 / / SYM cord-006856-b1w25ob5 1668 50 ml ml NN cord-006856-b1w25ob5 1668 51 . . . cord-006856-b1w25ob5 1669 1 Background background NN cord-006856-b1w25ob5 1669 2 . . . cord-006856-b1w25ob5 1670 1 Certain certain JJ cord-006856-b1w25ob5 1670 2 anatomical anatomical JJ cord-006856-b1w25ob5 1670 3 variations variation NNS cord-006856-b1w25ob5 1670 4 mainly mainly RB cord-006856-b1w25ob5 1670 5 concerning concern VBG cord-006856-b1w25ob5 1670 6 the the DT cord-006856-b1w25ob5 1670 7 portal portal JJ cord-006856-b1w25ob5 1670 8 system system NN cord-006856-b1w25ob5 1670 9 preclude preclude VBP cord-006856-b1w25ob5 1670 10 living live VBG cord-006856-b1w25ob5 1670 11 donor donor NN cord-006856-b1w25ob5 1670 12 liver liver NN cord-006856-b1w25ob5 1670 13 transplantation transplantation NN cord-006856-b1w25ob5 1670 14 ( ( -LRB- cord-006856-b1w25ob5 1670 15 LDLT LDLT NNP cord-006856-b1w25ob5 1670 16 ) ) -RRB- cord-006856-b1w25ob5 1670 17 . . . cord-006856-b1w25ob5 1671 1 To to IN cord-006856-b1w25ob5 1671 2 the the DT cord-006856-b1w25ob5 1671 3 best good JJS cord-006856-b1w25ob5 1671 4 of of IN cord-006856-b1w25ob5 1671 5 our -PRON- PRP$ cord-006856-b1w25ob5 1671 6 knowledge knowledge NN cord-006856-b1w25ob5 1671 7 , , , cord-006856-b1w25ob5 1671 8 two two CD cord-006856-b1w25ob5 1671 9 left leave VBN cord-006856-b1w25ob5 1671 10 lateral lateral JJ cord-006856-b1w25ob5 1671 11 segments segment NNS cord-006856-b1w25ob5 1671 12 with with IN cord-006856-b1w25ob5 1671 13 two two CD cord-006856-b1w25ob5 1671 14 arteries artery NNS cord-006856-b1w25ob5 1671 15 have have VBP cord-006856-b1w25ob5 1671 16 never never RB cord-006856-b1w25ob5 1671 17 been be VBN cord-006856-b1w25ob5 1671 18 transplanted transplant VBN cord-006856-b1w25ob5 1671 19 so so RB cord-006856-b1w25ob5 1671 20 far far RB cord-006856-b1w25ob5 1671 21 . . . cord-006856-b1w25ob5 1672 1 Case case NN cord-006856-b1w25ob5 1672 2 report report NN cord-006856-b1w25ob5 1672 3 . . . cord-006856-b1w25ob5 1673 1 A a DT cord-006856-b1w25ob5 1673 2 6-month 6-month CD cord-006856-b1w25ob5 1673 3 - - HYPH cord-006856-b1w25ob5 1673 4 old old JJ cord-006856-b1w25ob5 1673 5 girl girl NN cord-006856-b1w25ob5 1673 6 was be VBD cord-006856-b1w25ob5 1673 7 diagnosed diagnose VBN cord-006856-b1w25ob5 1673 8 with with IN cord-006856-b1w25ob5 1673 9 endstage endstage NN cord-006856-b1w25ob5 1673 10 liver liver NN cord-006856-b1w25ob5 1673 11 cirrhosis cirrhosis NN cord-006856-b1w25ob5 1673 12 secondary secondary JJ cord-006856-b1w25ob5 1673 13 to to IN cord-006856-b1w25ob5 1673 14 biliary biliary JJ cord-006856-b1w25ob5 1673 15 atresia atresia NN cord-006856-b1w25ob5 1673 16 and and CC cord-006856-b1w25ob5 1673 17 therefore therefore RB cord-006856-b1w25ob5 1673 18 scheduled schedule VBN cord-006856-b1w25ob5 1673 19 for for IN cord-006856-b1w25ob5 1673 20 LDLT LDLT NNP cord-006856-b1w25ob5 1673 21 . . . cord-006856-b1w25ob5 1674 1 Preoperative preoperative JJ cord-006856-b1w25ob5 1674 2 evaluation evaluation NN cord-006856-b1w25ob5 1674 3 of of IN cord-006856-b1w25ob5 1674 4 the the DT cord-006856-b1w25ob5 1674 5 donor donor NN cord-006856-b1w25ob5 1674 6 including include VBG cord-006856-b1w25ob5 1674 7 CT CT NNP cord-006856-b1w25ob5 1674 8 with with IN cord-006856-b1w25ob5 1674 9 3-D 3-d JJ cord-006856-b1w25ob5 1674 10 reconstruction reconstruction NN cord-006856-b1w25ob5 1674 11 revealed reveal VBD cord-006856-b1w25ob5 1674 12 normal normal JJ cord-006856-b1w25ob5 1674 13 vascular vascular JJ cord-006856-b1w25ob5 1674 14 supply supply NN cord-006856-b1w25ob5 1674 15 of of IN cord-006856-b1w25ob5 1674 16 the the DT cord-006856-b1w25ob5 1674 17 liver liver NN cord-006856-b1w25ob5 1674 18 with with IN cord-006856-b1w25ob5 1674 19 a a DT cord-006856-b1w25ob5 1674 20 left left NN cord-006856-b1w25ob5 1674 21 and and CC cord-006856-b1w25ob5 1674 22 a a DT cord-006856-b1w25ob5 1674 23 right right JJ cord-006856-b1w25ob5 1674 24 hepatic hepatic JJ cord-006856-b1w25ob5 1674 25 artery artery NN cord-006856-b1w25ob5 1674 26 . . . cord-006856-b1w25ob5 1675 1 During during IN cord-006856-b1w25ob5 1675 2 donor donor NN cord-006856-b1w25ob5 1675 3 operation operation NN cord-006856-b1w25ob5 1675 4 , , , cord-006856-b1w25ob5 1675 5 two two CD cord-006856-b1w25ob5 1675 6 tiny tiny JJ cord-006856-b1w25ob5 1675 7 arteries artery NNS cord-006856-b1w25ob5 1675 8 with with IN cord-006856-b1w25ob5 1675 9 a a DT cord-006856-b1w25ob5 1675 10 diameter diameter NN cord-006856-b1w25ob5 1675 11 of of IN cord-006856-b1w25ob5 1675 12 2 2 CD cord-006856-b1w25ob5 1675 13 mm mm NNS cord-006856-b1w25ob5 1675 14 for for IN cord-006856-b1w25ob5 1675 15 segments segment NNS cord-006856-b1w25ob5 1675 16 II II NNP cord-006856-b1w25ob5 1675 17 and and CC cord-006856-b1w25ob5 1675 18 III III NNP cord-006856-b1w25ob5 1675 19 were be VBD cord-006856-b1w25ob5 1675 20 identified identify VBN cord-006856-b1w25ob5 1675 21 . . . cord-006856-b1w25ob5 1676 1 They -PRON- PRP cord-006856-b1w25ob5 1676 2 were be VBD cord-006856-b1w25ob5 1676 3 found find VBN cord-006856-b1w25ob5 1676 4 to to TO cord-006856-b1w25ob5 1676 5 arise arise VB cord-006856-b1w25ob5 1676 6 from from IN cord-006856-b1w25ob5 1676 7 the the DT cord-006856-b1w25ob5 1676 8 left left JJ cord-006856-b1w25ob5 1676 9 hepatic hepatic JJ cord-006856-b1w25ob5 1676 10 artery artery NN cord-006856-b1w25ob5 1676 11 right right RB cord-006856-b1w25ob5 1676 12 behind behind IN cord-006856-b1w25ob5 1676 13 the the DT cord-006856-b1w25ob5 1676 14 bifurcation bifurcation NN cord-006856-b1w25ob5 1676 15 of of IN cord-006856-b1w25ob5 1676 16 the the DT cord-006856-b1w25ob5 1676 17 proper proper JJ cord-006856-b1w25ob5 1676 18 hepatic hepatic JJ cord-006856-b1w25ob5 1676 19 artery artery NN cord-006856-b1w25ob5 1676 20 , , , cord-006856-b1w25ob5 1676 21 which which WDT cord-006856-b1w25ob5 1676 22 made make VBD cord-006856-b1w25ob5 1676 23 it -PRON- PRP cord-006856-b1w25ob5 1676 24 impossible impossible JJ cord-006856-b1w25ob5 1676 25 to to TO cord-006856-b1w25ob5 1676 26 preserve preserve VB cord-006856-b1w25ob5 1676 27 a a DT cord-006856-b1w25ob5 1676 28 common common JJ cord-006856-b1w25ob5 1676 29 trunk trunk NN cord-006856-b1w25ob5 1676 30 . . . cord-006856-b1w25ob5 1677 1 Venous venous JJ cord-006856-b1w25ob5 1677 2 and and CC cord-006856-b1w25ob5 1677 3 portal portal JJ cord-006856-b1w25ob5 1677 4 venous venous JJ cord-006856-b1w25ob5 1677 5 reconstruction reconstruction NN cord-006856-b1w25ob5 1677 6 was be VBD cord-006856-b1w25ob5 1677 7 performed perform VBN cord-006856-b1w25ob5 1677 8 in in IN cord-006856-b1w25ob5 1677 9 an an DT cord-006856-b1w25ob5 1677 10 end end NN cord-006856-b1w25ob5 1677 11 - - HYPH cord-006856-b1w25ob5 1677 12 to to IN cord-006856-b1w25ob5 1677 13 - - HYPH cord-006856-b1w25ob5 1677 14 end end NN cord-006856-b1w25ob5 1677 15 fashion fashion NN cord-006856-b1w25ob5 1677 16 . . . cord-006856-b1w25ob5 1678 1 The the DT cord-006856-b1w25ob5 1678 2 left left JJ cord-006856-b1w25ob5 1678 3 graft graft NN cord-006856-b1w25ob5 1678 4 artery artery NN cord-006856-b1w25ob5 1678 5 was be VBD cord-006856-b1w25ob5 1678 6 directly directly RB cord-006856-b1w25ob5 1678 7 anastomosed anastomose VBN cord-006856-b1w25ob5 1678 8 to to IN cord-006856-b1w25ob5 1678 9 the the DT cord-006856-b1w25ob5 1678 10 proper proper JJ cord-006856-b1w25ob5 1678 11 hepatic hepatic JJ cord-006856-b1w25ob5 1678 12 artery artery NN cord-006856-b1w25ob5 1678 13 with with IN cord-006856-b1w25ob5 1678 14 8/0 8/0 CD cord-006856-b1w25ob5 1678 15 PDS PDS NNP cord-006856-b1w25ob5 1678 16 interrupted interrupt VBD cord-006856-b1w25ob5 1678 17 sutures suture NNS cord-006856-b1w25ob5 1678 18 using use VBG cord-006856-b1w25ob5 1678 19 a a DT cord-006856-b1w25ob5 1678 20 microscope microscope NN cord-006856-b1w25ob5 1678 21 . . . cord-006856-b1w25ob5 1679 1 The the DT cord-006856-b1w25ob5 1679 2 2nd 2nd JJ cord-006856-b1w25ob5 1679 3 graft graft NN cord-006856-b1w25ob5 1679 4 artery artery NN cord-006856-b1w25ob5 1679 5 was be VBD cord-006856-b1w25ob5 1679 6 revascularised revascularise VBN cord-006856-b1w25ob5 1679 7 with with IN cord-006856-b1w25ob5 1679 8 the the DT cord-006856-b1w25ob5 1679 9 help help NN cord-006856-b1w25ob5 1679 10 of of IN cord-006856-b1w25ob5 1679 11 saphenous saphenous JJ cord-006856-b1w25ob5 1679 12 vein vein NN cord-006856-b1w25ob5 1679 13 from from IN cord-006856-b1w25ob5 1679 14 the the DT cord-006856-b1w25ob5 1679 15 recipient recipient NN cord-006856-b1w25ob5 1679 16 as as IN cord-006856-b1w25ob5 1679 17 interposition interposition NN cord-006856-b1w25ob5 1679 18 graft graft NN cord-006856-b1w25ob5 1679 19 to to IN cord-006856-b1w25ob5 1679 20 the the DT cord-006856-b1w25ob5 1679 21 gastroduodenal gastroduodenal JJ cord-006856-b1w25ob5 1679 22 artery artery NN cord-006856-b1w25ob5 1679 23 but but CC cord-006856-b1w25ob5 1679 24 failed fail VBD cord-006856-b1w25ob5 1679 25 . . . cord-006856-b1w25ob5 1680 1 Therefore therefore RB cord-006856-b1w25ob5 1680 2 , , , cord-006856-b1w25ob5 1680 3 the the DT cord-006856-b1w25ob5 1680 4 trunk trunk NN cord-006856-b1w25ob5 1680 5 of of IN cord-006856-b1w25ob5 1680 6 the the DT cord-006856-b1w25ob5 1680 7 inferior inferior JJ cord-006856-b1w25ob5 1680 8 mesenteric mesenteric JJ cord-006856-b1w25ob5 1680 9 vein vein NN cord-006856-b1w25ob5 1680 10 was be VBD cord-006856-b1w25ob5 1680 11 used use VBN cord-006856-b1w25ob5 1680 12 for for IN cord-006856-b1w25ob5 1680 13 reconstruction reconstruction NN cord-006856-b1w25ob5 1680 14 with with IN cord-006856-b1w25ob5 1680 15 8/0 8/0 CD cord-006856-b1w25ob5 1680 16 PDS PDS NNP cord-006856-b1w25ob5 1680 17 with with IN cord-006856-b1w25ob5 1680 18 excellent excellent JJ cord-006856-b1w25ob5 1680 19 outcome outcome NN cord-006856-b1w25ob5 1680 20 . . . cord-006856-b1w25ob5 1681 1 Under under IN cord-006856-b1w25ob5 1681 2 FK FK NNP cord-006856-b1w25ob5 1681 3 - - HYPH cord-006856-b1w25ob5 1681 4 based base VBN cord-006856-b1w25ob5 1681 5 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1681 6 , , , cord-006856-b1w25ob5 1681 7 postoperative postoperative JJ cord-006856-b1w25ob5 1681 8 course course NN cord-006856-b1w25ob5 1681 9 was be VBD cord-006856-b1w25ob5 1681 10 uneventful uneventful JJ cord-006856-b1w25ob5 1681 11 with with IN cord-006856-b1w25ob5 1681 12 both both DT cord-006856-b1w25ob5 1681 13 arteries artery NNS cord-006856-b1w25ob5 1681 14 patent patent NN cord-006856-b1w25ob5 1681 15 . . . cord-006856-b1w25ob5 1682 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1682 2 . . . cord-006856-b1w25ob5 1683 1 Multiple multiple JJ cord-006856-b1w25ob5 1683 2 arteries artery NNS cord-006856-b1w25ob5 1683 3 for for IN cord-006856-b1w25ob5 1683 4 the the DT cord-006856-b1w25ob5 1683 5 left left JJ cord-006856-b1w25ob5 1683 6 lateral lateral JJ cord-006856-b1w25ob5 1683 7 segments segment NNS cord-006856-b1w25ob5 1683 8 are be VBP cord-006856-b1w25ob5 1683 9 not not RB cord-006856-b1w25ob5 1683 10 a a DT cord-006856-b1w25ob5 1683 11 contraindication contraindication NN cord-006856-b1w25ob5 1683 12 for for IN cord-006856-b1w25ob5 1683 13 paediatric paediatric JJ cord-006856-b1w25ob5 1683 14 LDLT LDLT NNP cord-006856-b1w25ob5 1683 15 . . . cord-006856-b1w25ob5 1684 1 The the DT cord-006856-b1w25ob5 1684 2 inferior inferior JJ cord-006856-b1w25ob5 1684 3 mesenteric mesenteric JJ cord-006856-b1w25ob5 1684 4 vein vein NN cord-006856-b1w25ob5 1684 5 can can MD cord-006856-b1w25ob5 1684 6 be be VB cord-006856-b1w25ob5 1684 7 used use VBN cord-006856-b1w25ob5 1684 8 as as IN cord-006856-b1w25ob5 1684 9 an an DT cord-006856-b1w25ob5 1684 10 interposition interposition NN cord-006856-b1w25ob5 1684 11 graft graft NN cord-006856-b1w25ob5 1684 12 . . . cord-006856-b1w25ob5 1685 1 Combined combined JJ cord-006856-b1w25ob5 1685 2 renal renal JJ cord-006856-b1w25ob5 1685 3 - - HYPH cord-006856-b1w25ob5 1685 4 pancreas pancreas NN cord-006856-b1w25ob5 1685 5 transplantation transplantation NN cord-006856-b1w25ob5 1685 6 is be VBZ cord-006856-b1w25ob5 1685 7 an an DT cord-006856-b1w25ob5 1685 8 established establish VBN cord-006856-b1w25ob5 1685 9 treatment treatment NN cord-006856-b1w25ob5 1685 10 for for IN cord-006856-b1w25ob5 1685 11 patients patient NNS cord-006856-b1w25ob5 1685 12 with with IN cord-006856-b1w25ob5 1685 13 diabetic diabetic JJ cord-006856-b1w25ob5 1685 14 nephropathy nephropathy NN cord-006856-b1w25ob5 1685 15 , , , cord-006856-b1w25ob5 1685 16 producing produce VBG cord-006856-b1w25ob5 1685 17 excellent excellent JJ cord-006856-b1w25ob5 1685 18 results result NNS cord-006856-b1w25ob5 1685 19 . . . cord-006856-b1w25ob5 1686 1 We -PRON- PRP cord-006856-b1w25ob5 1686 2 report report VBP cord-006856-b1w25ob5 1686 3 on on IN cord-006856-b1w25ob5 1686 4 a a DT cord-006856-b1w25ob5 1686 5 patient patient NN cord-006856-b1w25ob5 1686 6 who who WP cord-006856-b1w25ob5 1686 7 suffered suffer VBD cord-006856-b1w25ob5 1686 8 from from IN cord-006856-b1w25ob5 1686 9 long long RB cord-006856-b1w25ob5 1686 10 - - HYPH cord-006856-b1w25ob5 1686 11 standing stand VBG cord-006856-b1w25ob5 1686 12 multiple multiple JJ cord-006856-b1w25ob5 1686 13 sclerosis sclerosis NN cord-006856-b1w25ob5 1686 14 and and CC cord-006856-b1w25ob5 1686 15 underwent undergo VBD cord-006856-b1w25ob5 1686 16 successful successful JJ cord-006856-b1w25ob5 1686 17 combined combined JJ cord-006856-b1w25ob5 1686 18 renal renal JJ cord-006856-b1w25ob5 1686 19 - - HYPH cord-006856-b1w25ob5 1686 20 pancreas pancreas NN cord-006856-b1w25ob5 1686 21 transplantation transplantation NN cord-006856-b1w25ob5 1686 22 . . . cord-006856-b1w25ob5 1687 1 Post post JJ cord-006856-b1w25ob5 1687 2 transplant transplant NN cord-006856-b1w25ob5 1687 3 course course NN cord-006856-b1w25ob5 1687 4 was be VBD cord-006856-b1w25ob5 1687 5 complicated complicate VBN cord-006856-b1w25ob5 1687 6 by by IN cord-006856-b1w25ob5 1687 7 yeast yeast NN cord-006856-b1w25ob5 1687 8 intra intra JJ cord-006856-b1w25ob5 1687 9 - - JJ cord-006856-b1w25ob5 1687 10 abdominal abdominal JJ cord-006856-b1w25ob5 1687 11 infection infection NN cord-006856-b1w25ob5 1687 12 , , , cord-006856-b1w25ob5 1687 13 which which WDT cord-006856-b1w25ob5 1687 14 was be VBD cord-006856-b1w25ob5 1687 15 treated treat VBN cord-006856-b1w25ob5 1687 16 with with IN cord-006856-b1w25ob5 1687 17 antifungal antifungal JJ cord-006856-b1w25ob5 1687 18 agents agent NNS cord-006856-b1w25ob5 1687 19 . . . cord-006856-b1w25ob5 1688 1 Using use VBG cord-006856-b1w25ob5 1688 2 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1688 3 and and CC cord-006856-b1w25ob5 1688 4 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1688 5 , , , cord-006856-b1w25ob5 1688 6 both both DT cord-006856-b1w25ob5 1688 7 grafts graft NNS cord-006856-b1w25ob5 1688 8 are be VBP cord-006856-b1w25ob5 1688 9 well well RB cord-006856-b1w25ob5 1688 10 functioning function VBG cord-006856-b1w25ob5 1688 11 at at IN cord-006856-b1w25ob5 1688 12 two two CD cord-006856-b1w25ob5 1688 13 years year NNS cord-006856-b1w25ob5 1688 14 and and CC cord-006856-b1w25ob5 1688 15 the the DT cord-006856-b1w25ob5 1688 16 patient patient NN cord-006856-b1w25ob5 1688 17 is be VBZ cord-006856-b1w25ob5 1688 18 without without IN cord-006856-b1w25ob5 1688 19 any any DT cord-006856-b1w25ob5 1688 20 symptoms symptom NNS cord-006856-b1w25ob5 1688 21 of of IN cord-006856-b1w25ob5 1688 22 disseminated disseminate VBN cord-006856-b1w25ob5 1688 23 encephalitis encephalitis NN cord-006856-b1w25ob5 1688 24 and and CC cord-006856-b1w25ob5 1688 25 does do VBZ cord-006856-b1w25ob5 1688 26 not not RB cord-006856-b1w25ob5 1688 27 require require VB cord-006856-b1w25ob5 1688 28 specific specific JJ cord-006856-b1w25ob5 1688 29 medication medication NN cord-006856-b1w25ob5 1688 30 for for IN cord-006856-b1w25ob5 1688 31 multiple multiple JJ cord-006856-b1w25ob5 1688 32 sclerosis sclerosis NN cord-006856-b1w25ob5 1688 33 . . . cord-006856-b1w25ob5 1689 1 For for IN cord-006856-b1w25ob5 1689 2 diabetic diabetic JJ cord-006856-b1w25ob5 1689 3 patients patient NNS cord-006856-b1w25ob5 1689 4 suffering suffer VBG cord-006856-b1w25ob5 1689 5 from from IN cord-006856-b1w25ob5 1689 6 multiple multiple JJ cord-006856-b1w25ob5 1689 7 sclerosis sclerosis NN cord-006856-b1w25ob5 1689 8 , , , cord-006856-b1w25ob5 1689 9 pancreas pancreas NN cord-006856-b1w25ob5 1689 10 transplantation transplantation NN cord-006856-b1w25ob5 1689 11 offers offer VBZ cord-006856-b1w25ob5 1689 12 an an DT cord-006856-b1w25ob5 1689 13 excellent excellent JJ cord-006856-b1w25ob5 1689 14 treatment treatment NN cord-006856-b1w25ob5 1689 15 option option NN cord-006856-b1w25ob5 1689 16 . . . cord-006856-b1w25ob5 1690 1 Whether whether IN cord-006856-b1w25ob5 1690 2 normalisation normalisation NN cord-006856-b1w25ob5 1690 3 of of IN cord-006856-b1w25ob5 1690 4 carbohydrate carbohydrate NN cord-006856-b1w25ob5 1690 5 metabolism metabolism NN cord-006856-b1w25ob5 1690 6 or or CC cord-006856-b1w25ob5 1690 7 chronic chronic JJ cord-006856-b1w25ob5 1690 8 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1690 9 or or CC cord-006856-b1w25ob5 1690 10 both both DT cord-006856-b1w25ob5 1690 11 lead lead VBP cord-006856-b1w25ob5 1690 12 to to TO cord-006856-b1w25ob5 1690 13 complete complete VB cord-006856-b1w25ob5 1690 14 response response NN cord-006856-b1w25ob5 1690 15 of of IN cord-006856-b1w25ob5 1690 16 multiple multiple JJ cord-006856-b1w25ob5 1690 17 sclerosis sclerosis NN cord-006856-b1w25ob5 1690 18 is be VBZ cord-006856-b1w25ob5 1690 19 not not RB cord-006856-b1w25ob5 1690 20 clear clear JJ cord-006856-b1w25ob5 1690 21 . . . cord-006856-b1w25ob5 1691 1 Background background NN cord-006856-b1w25ob5 1691 2 . . . cord-006856-b1w25ob5 1692 1 Until until IN cord-006856-b1w25ob5 1692 2 recently recently RB cord-006856-b1w25ob5 1692 3 , , , cord-006856-b1w25ob5 1692 4 the the DT cord-006856-b1w25ob5 1692 5 peripheral peripheral JJ cord-006856-b1w25ob5 1692 6 blood blood NN cord-006856-b1w25ob5 1692 7 stem stem NN cord-006856-b1w25ob5 1692 8 cell cell NN cord-006856-b1w25ob5 1692 9 ( ( -LRB- cord-006856-b1w25ob5 1692 10 PBSC PBSC NNP cord-006856-b1w25ob5 1692 11 ) ) -RRB- cord-006856-b1w25ob5 1692 12 donation donation NN cord-006856-b1w25ob5 1692 13 procedure procedure NN cord-006856-b1w25ob5 1692 14 was be VBD cord-006856-b1w25ob5 1692 15 used use VBN cord-006856-b1w25ob5 1692 16 only only RB cord-006856-b1w25ob5 1692 17 infrequently infrequently RB cord-006856-b1w25ob5 1692 18 among among IN cord-006856-b1w25ob5 1692 19 unrelated unrelated JJ cord-006856-b1w25ob5 1692 20 allogeneic allogeneic IN cord-006856-b1w25ob5 1692 21 donors donor NNS cord-006856-b1w25ob5 1692 22 . . . cord-006856-b1w25ob5 1693 1 Nowadays nowadays RB cord-006856-b1w25ob5 1693 2 , , , cord-006856-b1w25ob5 1693 3 both both CC cord-006856-b1w25ob5 1693 4 related related JJ cord-006856-b1w25ob5 1693 5 and and CC cord-006856-b1w25ob5 1693 6 unrelated unrelated JJ cord-006856-b1w25ob5 1693 7 donors donor NNS cord-006856-b1w25ob5 1693 8 are be VBP cord-006856-b1w25ob5 1693 9 expected expect VBN cord-006856-b1w25ob5 1693 10 to to TO cord-006856-b1w25ob5 1693 11 consider consider VB cord-006856-b1w25ob5 1693 12 this this DT cord-006856-b1w25ob5 1693 13 alternative alternative JJ cord-006856-b1w25ob5 1693 14 donation donation NN cord-006856-b1w25ob5 1693 15 . . . cord-006856-b1w25ob5 1694 1 To to TO cord-006856-b1w25ob5 1694 2 promote promote VB cord-006856-b1w25ob5 1694 3 PBSC PBSC NNP cord-006856-b1w25ob5 1694 4 donation donation NN cord-006856-b1w25ob5 1694 5 both both CC cord-006856-b1w25ob5 1694 6 safety safety NN cord-006856-b1w25ob5 1694 7 and and CC cord-006856-b1w25ob5 1694 8 well well RB cord-006856-b1w25ob5 1694 9 - - HYPH cord-006856-b1w25ob5 1694 10 being being NN cord-006856-b1w25ob5 1694 11 of of IN cord-006856-b1w25ob5 1694 12 healthy healthy JJ cord-006856-b1w25ob5 1694 13 unrelated unrelated JJ cord-006856-b1w25ob5 1694 14 volunteer volunteer NN cord-006856-b1w25ob5 1694 15 donors donor NNS cord-006856-b1w25ob5 1694 16 must must MD cord-006856-b1w25ob5 1694 17 be be VB cord-006856-b1w25ob5 1694 18 protected protect VBN cord-006856-b1w25ob5 1694 19 and and CC cord-006856-b1w25ob5 1694 20 data datum NNS cord-006856-b1w25ob5 1694 21 are be VBP cord-006856-b1w25ob5 1694 22 to to TO cord-006856-b1w25ob5 1694 23 be be VB cord-006856-b1w25ob5 1694 24 collected collect VBN cord-006856-b1w25ob5 1694 25 to to TO cord-006856-b1w25ob5 1694 26 establish establish VB cord-006856-b1w25ob5 1694 27 the the DT cord-006856-b1w25ob5 1694 28 long long JJ cord-006856-b1w25ob5 1694 29 - - HYPH cord-006856-b1w25ob5 1694 30 term term NN cord-006856-b1w25ob5 1694 31 safety safety NN cord-006856-b1w25ob5 1694 32 of of IN cord-006856-b1w25ob5 1694 33 G G NNP cord-006856-b1w25ob5 1694 34 - - HYPH cord-006856-b1w25ob5 1694 35 CSF csf NN cord-006856-b1w25ob5 1694 36 stimulation stimulation NN cord-006856-b1w25ob5 1694 37 . . . cord-006856-b1w25ob5 1695 1 Methods method NNS cord-006856-b1w25ob5 1695 2 . . . cord-006856-b1w25ob5 1696 1 From from IN cord-006856-b1w25ob5 1696 2 2000 2000 CD cord-006856-b1w25ob5 1696 3 to to IN cord-006856-b1w25ob5 1696 4 2004 2004 CD cord-006856-b1w25ob5 1696 5 , , , cord-006856-b1w25ob5 1696 6 16 16 CD cord-006856-b1w25ob5 1696 7 PBSC PBSC NNP cord-006856-b1w25ob5 1696 8 aphereses apherese NNS cord-006856-b1w25ob5 1696 9 on on IN cord-006856-b1w25ob5 1696 10 unrelated unrelated JJ cord-006856-b1w25ob5 1696 11 allogeneic allogeneic IN cord-006856-b1w25ob5 1696 12 donors donor NNS cord-006856-b1w25ob5 1696 13 have have VBP cord-006856-b1w25ob5 1696 14 been be VBN cord-006856-b1w25ob5 1696 15 carried carry VBN cord-006856-b1w25ob5 1696 16 out out RP cord-006856-b1w25ob5 1696 17 in in IN cord-006856-b1w25ob5 1696 18 our -PRON- PRP$ cord-006856-b1w25ob5 1696 19 center center NN cord-006856-b1w25ob5 1696 20 . . . cord-006856-b1w25ob5 1697 1 All all DT cord-006856-b1w25ob5 1697 2 PBSC PBSC NNP cord-006856-b1w25ob5 1697 3 donors donor NNS cord-006856-b1w25ob5 1697 4 were be VBD cord-006856-b1w25ob5 1697 5 treated treat VBN cord-006856-b1w25ob5 1697 6 with with IN cord-006856-b1w25ob5 1697 7 5 5 CD cord-006856-b1w25ob5 1697 8 µg µg NN cord-006856-b1w25ob5 1697 9 of of IN cord-006856-b1w25ob5 1697 10 G G NNP cord-006856-b1w25ob5 1697 11 - - HYPH cord-006856-b1w25ob5 1697 12 CSF csf NN cord-006856-b1w25ob5 1697 13 per per IN cord-006856-b1w25ob5 1697 14 kg kg NNS cord-006856-b1w25ob5 1697 15 twice twice PDT cord-006856-b1w25ob5 1697 16 a a DT cord-006856-b1w25ob5 1697 17 day day NN cord-006856-b1w25ob5 1697 18 from from IN cord-006856-b1w25ob5 1697 19 day day NN cord-006856-b1w25ob5 1697 20 -4 -4 NNP cord-006856-b1w25ob5 1697 21 to to IN cord-006856-b1w25ob5 1697 22 day day NN cord-006856-b1w25ob5 1697 23 -1 -1 CD cord-006856-b1w25ob5 1697 24 . . . cord-006856-b1w25ob5 1698 1 Aphereses apherese NNS cord-006856-b1w25ob5 1698 2 were be VBD cord-006856-b1w25ob5 1698 3 performed perform VBN cord-006856-b1w25ob5 1698 4 using use VBG cord-006856-b1w25ob5 1698 5 peripheral peripheral JJ cord-006856-b1w25ob5 1698 6 venous venous JJ cord-006856-b1w25ob5 1698 7 access access NN cord-006856-b1w25ob5 1698 8 on on IN cord-006856-b1w25ob5 1698 9 day day NN cord-006856-b1w25ob5 1698 10 0 0 CD cord-006856-b1w25ob5 1698 11 and and CC cord-006856-b1w25ob5 1698 12 -if -if CD cord-006856-b1w25ob5 1698 13 indicatedon indicatedon NNP cord-006856-b1w25ob5 1698 14 day day NNP cord-006856-b1w25ob5 1698 15 1 1 CD cord-006856-b1w25ob5 1698 16 . . . cord-006856-b1w25ob5 1699 1 Since since IN cord-006856-b1w25ob5 1699 2 2003 2003 CD cord-006856-b1w25ob5 1699 3 , , , cord-006856-b1w25ob5 1699 4 all all DT cord-006856-b1w25ob5 1699 5 donors donor NNS cord-006856-b1w25ob5 1699 6 have have VBP cord-006856-b1w25ob5 1699 7 annually annually RB cord-006856-b1w25ob5 1699 8 received receive VBN cord-006856-b1w25ob5 1699 9 a a DT cord-006856-b1w25ob5 1699 10 questionnaire questionnaire NN cord-006856-b1w25ob5 1699 11 about about IN cord-006856-b1w25ob5 1699 12 their -PRON- PRP$ cord-006856-b1w25ob5 1699 13 actual actual JJ cord-006856-b1w25ob5 1699 14 state state NN cord-006856-b1w25ob5 1699 15 of of IN cord-006856-b1w25ob5 1699 16 health health NN cord-006856-b1w25ob5 1699 17 and and CC cord-006856-b1w25ob5 1699 18 medication medication NN cord-006856-b1w25ob5 1699 19 , , , cord-006856-b1w25ob5 1699 20 as as RB cord-006856-b1w25ob5 1699 21 well well RB cord-006856-b1w25ob5 1699 22 as as IN cord-006856-b1w25ob5 1699 23 their -PRON- PRP$ cord-006856-b1w25ob5 1699 24 physical physical JJ cord-006856-b1w25ob5 1699 25 and and CC cord-006856-b1w25ob5 1699 26 mental mental JJ cord-006856-b1w25ob5 1699 27 conditions condition NNS cord-006856-b1w25ob5 1699 28 . . . cord-006856-b1w25ob5 1700 1 Detailed detailed JJ cord-006856-b1w25ob5 1700 2 questions question NNS cord-006856-b1w25ob5 1700 3 concerned concern VBD cord-006856-b1w25ob5 1700 4 donors donor NNS cord-006856-b1w25ob5 1700 5 ' ' POS cord-006856-b1w25ob5 1700 6 anamnesis anamnesis NN cord-006856-b1w25ob5 1700 7 for for IN cord-006856-b1w25ob5 1700 8 epistaxis epistaxis NN cord-006856-b1w25ob5 1700 9 , , , cord-006856-b1w25ob5 1700 10 bruises bruise NNS cord-006856-b1w25ob5 1700 11 , , , cord-006856-b1w25ob5 1700 12 thrombosis thrombosis NN cord-006856-b1w25ob5 1700 13 or or CC cord-006856-b1w25ob5 1700 14 embolia embolia NNP cord-006856-b1w25ob5 1700 15 , , , cord-006856-b1w25ob5 1700 16 as as RB cord-006856-b1w25ob5 1700 17 well well RB cord-006856-b1w25ob5 1700 18 as as IN cord-006856-b1w25ob5 1700 19 infections infection NNS cord-006856-b1w25ob5 1700 20 and and CC cord-006856-b1w25ob5 1700 21 fever fever NN cord-006856-b1w25ob5 1700 22 , , , cord-006856-b1w25ob5 1700 23 night night NN cord-006856-b1w25ob5 1700 24 sweat sweat NN cord-006856-b1w25ob5 1700 25 , , , cord-006856-b1w25ob5 1700 26 and and CC cord-006856-b1w25ob5 1700 27 weight weight NN cord-006856-b1w25ob5 1700 28 loss loss NN cord-006856-b1w25ob5 1700 29 of of IN cord-006856-b1w25ob5 1700 30 unclear unclear JJ cord-006856-b1w25ob5 1700 31 origin origin NN cord-006856-b1w25ob5 1700 32 . . . cord-006856-b1w25ob5 1701 1 Results result NNS cord-006856-b1w25ob5 1701 2 . . . cord-006856-b1w25ob5 1702 1 11 11 CD cord-006856-b1w25ob5 1702 2 male male NN cord-006856-b1w25ob5 1702 3 and and CC cord-006856-b1w25ob5 1702 4 2 2 CD cord-006856-b1w25ob5 1702 5 female female JJ cord-006856-b1w25ob5 1702 6 donors donor NNS cord-006856-b1w25ob5 1702 7 ( ( -LRB- cord-006856-b1w25ob5 1702 8 81 81 CD cord-006856-b1w25ob5 1702 9 % % NN cord-006856-b1w25ob5 1702 10 ) ) -RRB- cord-006856-b1w25ob5 1702 11 with with IN cord-006856-b1w25ob5 1702 12 an an DT cord-006856-b1w25ob5 1702 13 average average JJ cord-006856-b1w25ob5 1702 14 age age NN cord-006856-b1w25ob5 1702 15 of of IN cord-006856-b1w25ob5 1702 16 44.59 44.59 CD cord-006856-b1w25ob5 1702 17 ( ( -LRB- cord-006856-b1w25ob5 1702 18 29 29 CD cord-006856-b1w25ob5 1702 19 - - SYM cord-006856-b1w25ob5 1702 20 56 56 CD cord-006856-b1w25ob5 1702 21 ) ) -RRB- cord-006856-b1w25ob5 1702 22 years year NNS cord-006856-b1w25ob5 1702 23 responded respond VBD cord-006856-b1w25ob5 1702 24 to to IN cord-006856-b1w25ob5 1702 25 the the DT cord-006856-b1w25ob5 1702 26 questionnaire questionnaire NN cord-006856-b1w25ob5 1702 27 . . . cord-006856-b1w25ob5 1703 1 The the DT cord-006856-b1w25ob5 1703 2 observation observation NN cord-006856-b1w25ob5 1703 3 periods period NNS cord-006856-b1w25ob5 1703 4 were be VBD cord-006856-b1w25ob5 1703 5 between between IN cord-006856-b1w25ob5 1703 6 3 3 CD cord-006856-b1w25ob5 1703 7 and and CC cord-006856-b1w25ob5 1703 8 53 53 CD cord-006856-b1w25ob5 1703 9 months month NNS cord-006856-b1w25ob5 1703 10 ( ( -LRB- cord-006856-b1w25ob5 1703 11 mean mean UH cord-006856-b1w25ob5 1703 12 , , , cord-006856-b1w25ob5 1703 13 28.75 28.75 CD cord-006856-b1w25ob5 1703 14 months month NNS cord-006856-b1w25ob5 1703 15 ) ) -RRB- cord-006856-b1w25ob5 1703 16 after after IN cord-006856-b1w25ob5 1703 17 G G NNP cord-006856-b1w25ob5 1703 18 - - HYPH cord-006856-b1w25ob5 1703 19 CSF csf NN cord-006856-b1w25ob5 1703 20 stimulation stimulation NN cord-006856-b1w25ob5 1703 21 . . . cord-006856-b1w25ob5 1704 1 5 5 CD cord-006856-b1w25ob5 1704 2 PBSC PBSC NNP cord-006856-b1w25ob5 1704 3 donors donor NNS cord-006856-b1w25ob5 1704 4 ( ( -LRB- cord-006856-b1w25ob5 1704 5 38 38 CD cord-006856-b1w25ob5 1704 6 % % NN cord-006856-b1w25ob5 1704 7 , , , cord-006856-b1w25ob5 1704 8 all all DT cord-006856-b1w25ob5 1704 9 male male NN cord-006856-b1w25ob5 1704 10 ) ) -RRB- cord-006856-b1w25ob5 1704 11 reported report VBD cord-006856-b1w25ob5 1704 12 that that IN cord-006856-b1w25ob5 1704 13 they -PRON- PRP cord-006856-b1w25ob5 1704 14 had have VBD cord-006856-b1w25ob5 1704 15 been be VBN cord-006856-b1w25ob5 1704 16 severely severely RB cord-006856-b1w25ob5 1704 17 ill ill JJ cord-006856-b1w25ob5 1704 18 during during IN cord-006856-b1w25ob5 1704 19 the the DT cord-006856-b1w25ob5 1704 20 observation observation NN cord-006856-b1w25ob5 1704 21 period period NN cord-006856-b1w25ob5 1704 22 : : : cord-006856-b1w25ob5 1704 23 One one CD cord-006856-b1w25ob5 1704 24 donor donor NN cord-006856-b1w25ob5 1704 25 developed develop VBD cord-006856-b1w25ob5 1704 26 an an DT cord-006856-b1w25ob5 1704 27 exostosis exostosis NN cord-006856-b1w25ob5 1704 28 of of IN cord-006856-b1w25ob5 1704 29 the the DT cord-006856-b1w25ob5 1704 30 5th 5th JJ cord-006856-b1w25ob5 1704 31 rib rib NN cord-006856-b1w25ob5 1704 32 , , , cord-006856-b1w25ob5 1704 33 one one CD cord-006856-b1w25ob5 1704 34 was be VBD cord-006856-b1w25ob5 1704 35 operated operate VBN cord-006856-b1w25ob5 1704 36 on on IN cord-006856-b1w25ob5 1704 37 an an DT cord-006856-b1w25ob5 1704 38 umbilical umbilical JJ cord-006856-b1w25ob5 1704 39 hernia hernia NN cord-006856-b1w25ob5 1705 1 , , , cord-006856-b1w25ob5 1705 2 one one PRP cord-006856-b1w25ob5 1705 3 suffers suffer VBZ cord-006856-b1w25ob5 1705 4 from from IN cord-006856-b1w25ob5 1705 5 recurrent recurrent JJ cord-006856-b1w25ob5 1705 6 articular articular JJ cord-006856-b1w25ob5 1705 7 and and CC cord-006856-b1w25ob5 1705 8 muscle muscle NN cord-006856-b1w25ob5 1705 9 pain pain NN cord-006856-b1w25ob5 1705 10 accompanied accompany VBN cord-006856-b1w25ob5 1705 11 by by IN cord-006856-b1w25ob5 1705 12 night night NN cord-006856-b1w25ob5 1705 13 sweat sweat NN cord-006856-b1w25ob5 1705 14 and and CC cord-006856-b1w25ob5 1705 15 weight weight NN cord-006856-b1w25ob5 1705 16 loss loss NN cord-006856-b1w25ob5 1705 17 , , , cord-006856-b1w25ob5 1705 18 one one PRP cord-006856-b1w25ob5 1705 19 has have VBZ cord-006856-b1w25ob5 1705 20 a a DT cord-006856-b1w25ob5 1705 21 chronic chronic JJ cord-006856-b1w25ob5 1705 22 compensated compensate VBN cord-006856-b1w25ob5 1705 23 renal renal JJ cord-006856-b1w25ob5 1705 24 failure failure NN cord-006856-b1w25ob5 1705 25 , , , cord-006856-b1w25ob5 1705 26 one one PRP cord-006856-b1w25ob5 1705 27 had have VBD cord-006856-b1w25ob5 1705 28 diarrhoe diarrhoe NNS cord-006856-b1w25ob5 1705 29 and and CC cord-006856-b1w25ob5 1705 30 a a DT cord-006856-b1w25ob5 1705 31 common common JJ cord-006856-b1w25ob5 1705 32 cold cold NN cord-006856-b1w25ob5 1705 33 and and CC cord-006856-b1w25ob5 1705 34 suffered suffer VBD cord-006856-b1w25ob5 1705 35 from from IN cord-006856-b1w25ob5 1705 36 fatigue fatigue NN cord-006856-b1w25ob5 1705 37 , , , cord-006856-b1w25ob5 1705 38 nausea nausea NN cord-006856-b1w25ob5 1705 39 , , , cord-006856-b1w25ob5 1705 40 sleeping sleep VBG cord-006856-b1w25ob5 1705 41 problems problem NNS cord-006856-b1w25ob5 1705 42 , , , cord-006856-b1w25ob5 1705 43 and and CC cord-006856-b1w25ob5 1705 44 circulatory circulatory JJ cord-006856-b1w25ob5 1705 45 disorders disorder NNS cord-006856-b1w25ob5 1705 46 . . . cord-006856-b1w25ob5 1706 1 One one CD cord-006856-b1w25ob5 1706 2 female female JJ cord-006856-b1w25ob5 1706 3 donor donor NN cord-006856-b1w25ob5 1706 4 recognized recognize VBD cord-006856-b1w25ob5 1706 5 dizziness dizziness NN cord-006856-b1w25ob5 1706 6 and and CC cord-006856-b1w25ob5 1706 7 an an DT cord-006856-b1w25ob5 1706 8 increased increase VBN cord-006856-b1w25ob5 1706 9 tendency tendency NN cord-006856-b1w25ob5 1706 10 for for IN cord-006856-b1w25ob5 1706 11 bruises bruise NNS cord-006856-b1w25ob5 1706 12 as as RB cord-006856-b1w25ob5 1706 13 well well RB cord-006856-b1w25ob5 1706 14 as as IN cord-006856-b1w25ob5 1706 15 paraesthesia paraesthesia NN cord-006856-b1w25ob5 1706 16 in in IN cord-006856-b1w25ob5 1706 17 both both DT cord-006856-b1w25ob5 1706 18 arms arm NNS cord-006856-b1w25ob5 1706 19 . . . cord-006856-b1w25ob5 1707 1 The the DT cord-006856-b1w25ob5 1707 2 disorders disorder NNS cord-006856-b1w25ob5 1707 3 these these DT cord-006856-b1w25ob5 1707 4 donors donor NNS cord-006856-b1w25ob5 1707 5 reported report VBD cord-006856-b1w25ob5 1707 6 occurred occur VBD cord-006856-b1w25ob5 1707 7 between between IN cord-006856-b1w25ob5 1707 8 3 3 CD cord-006856-b1w25ob5 1707 9 and and CC cord-006856-b1w25ob5 1707 10 22 22 CD cord-006856-b1w25ob5 1707 11 months month NNS cord-006856-b1w25ob5 1707 12 after after IN cord-006856-b1w25ob5 1707 13 G g NN cord-006856-b1w25ob5 1707 14 - - HYPH cord-006856-b1w25ob5 1707 15 SCF scf NN cord-006856-b1w25ob5 1707 16 stimulation stimulation NN cord-006856-b1w25ob5 1707 17 . . . cord-006856-b1w25ob5 1708 1 All all PDT cord-006856-b1w25ob5 1708 2 the the DT cord-006856-b1w25ob5 1708 3 other other JJ cord-006856-b1w25ob5 1708 4 PBSC PBSC NNP cord-006856-b1w25ob5 1708 5 donors donor NNS cord-006856-b1w25ob5 1708 6 ( ( -LRB- cord-006856-b1w25ob5 1708 7 62 62 CD cord-006856-b1w25ob5 1708 8 % % NN cord-006856-b1w25ob5 1708 9 ) ) -RRB- cord-006856-b1w25ob5 1708 10 have have VBP cord-006856-b1w25ob5 1708 11 never never RB cord-006856-b1w25ob5 1708 12 been be VBN cord-006856-b1w25ob5 1708 13 severely severely RB cord-006856-b1w25ob5 1708 14 ill ill JJ cord-006856-b1w25ob5 1708 15 or or CC cord-006856-b1w25ob5 1708 16 under under IN cord-006856-b1w25ob5 1708 17 medical medical JJ cord-006856-b1w25ob5 1708 18 observation observation NN cord-006856-b1w25ob5 1708 19 . . . cord-006856-b1w25ob5 1709 1 No no DT cord-006856-b1w25ob5 1709 2 donor donor NN cord-006856-b1w25ob5 1709 3 had have VBD cord-006856-b1w25ob5 1709 4 fever fever NN cord-006856-b1w25ob5 1709 5 of of IN cord-006856-b1w25ob5 1709 6 unclear unclear JJ cord-006856-b1w25ob5 1709 7 origin origin NN cord-006856-b1w25ob5 1709 8 , , , cord-006856-b1w25ob5 1709 9 phlebitis phlebitis NN cord-006856-b1w25ob5 1709 10 , , , cord-006856-b1w25ob5 1709 11 thrombosis thrombosis NN cord-006856-b1w25ob5 1709 12 , , , cord-006856-b1w25ob5 1709 13 or or CC cord-006856-b1w25ob5 1709 14 embolia embolia NNP cord-006856-b1w25ob5 1709 15 , , , cord-006856-b1w25ob5 1709 16 no no DT cord-006856-b1w25ob5 1709 17 donor donor NN cord-006856-b1w25ob5 1709 18 recognized recognize VBD cord-006856-b1w25ob5 1709 19 an an DT cord-006856-b1w25ob5 1709 20 increased increase VBN cord-006856-b1w25ob5 1709 21 tendency tendency NN cord-006856-b1w25ob5 1709 22 for for IN cord-006856-b1w25ob5 1709 23 epistaxis epistaxis NN cord-006856-b1w25ob5 1709 24 . . . cord-006856-b1w25ob5 1710 1 Three three CD cord-006856-b1w25ob5 1710 2 donors donor NNS cord-006856-b1w25ob5 1710 3 need need VBP cord-006856-b1w25ob5 1710 4 medication medication NN cord-006856-b1w25ob5 1710 5 they -PRON- PRP cord-006856-b1w25ob5 1710 6 did do VBD cord-006856-b1w25ob5 1710 7 not not RB cord-006856-b1w25ob5 1710 8 have have VB cord-006856-b1w25ob5 1710 9 before before IN cord-006856-b1w25ob5 1710 10 G G NNP cord-006856-b1w25ob5 1710 11 - - HYPH cord-006856-b1w25ob5 1710 12 CSF csf NN cord-006856-b1w25ob5 1710 13 stimulation stimulation NN cord-006856-b1w25ob5 1710 14 , , , cord-006856-b1w25ob5 1710 15 which which WDT cord-006856-b1w25ob5 1710 16 are be VBP cord-006856-b1w25ob5 1710 17 to to TO cord-006856-b1w25ob5 1710 18 lower lower VB cord-006856-b1w25ob5 1710 19 blood blood NN cord-006856-b1w25ob5 1710 20 lipids lipid NNS cord-006856-b1w25ob5 1710 21 and and CC cord-006856-b1w25ob5 1710 22 anti anti JJ cord-006856-b1w25ob5 1710 23 - - JJ cord-006856-b1w25ob5 1710 24 inflammatory inflammatory JJ cord-006856-b1w25ob5 1710 25 ones one NNS cord-006856-b1w25ob5 1710 26 . . . cord-006856-b1w25ob5 1711 1 One one CD cord-006856-b1w25ob5 1711 2 donor donor NN cord-006856-b1w25ob5 1711 3 estimates estimate VBZ cord-006856-b1w25ob5 1711 4 that that IN cord-006856-b1w25ob5 1711 5 he -PRON- PRP cord-006856-b1w25ob5 1711 6 is be VBZ cord-006856-b1w25ob5 1711 7 getting get VBG cord-006856-b1w25ob5 1711 8 ill ill RB cord-006856-b1w25ob5 1711 9 more more RBR cord-006856-b1w25ob5 1711 10 easily easily RB cord-006856-b1w25ob5 1711 11 than than IN cord-006856-b1w25ob5 1711 12 others other NNS cord-006856-b1w25ob5 1711 13 , , , cord-006856-b1w25ob5 1711 14 all all PDT cord-006856-b1w25ob5 1711 15 the the DT cord-006856-b1w25ob5 1711 16 other other JJ cord-006856-b1w25ob5 1711 17 donors donor NNS cord-006856-b1w25ob5 1711 18 feel feel VBP cord-006856-b1w25ob5 1711 19 themselves -PRON- PRP cord-006856-b1w25ob5 1711 20 in in IN cord-006856-b1w25ob5 1711 21 best good JJS cord-006856-b1w25ob5 1711 22 physical physical JJ cord-006856-b1w25ob5 1711 23 and and CC cord-006856-b1w25ob5 1711 24 mental mental JJ cord-006856-b1w25ob5 1711 25 condition condition NN cord-006856-b1w25ob5 1711 26 . . . cord-006856-b1w25ob5 1712 1 Background background NN cord-006856-b1w25ob5 1712 2 . . . cord-006856-b1w25ob5 1713 1 Hematopoietic hematopoietic JJ cord-006856-b1w25ob5 1713 2 stem stem NN cord-006856-b1w25ob5 1713 3 cell cell NN cord-006856-b1w25ob5 1713 4 transplantation transplantation NN cord-006856-b1w25ob5 1713 5 ( ( -LRB- cord-006856-b1w25ob5 1713 6 HSCT HSCT NNP cord-006856-b1w25ob5 1713 7 ) ) -RRB- cord-006856-b1w25ob5 1713 8 has have VBZ cord-006856-b1w25ob5 1713 9 been be VBN cord-006856-b1w25ob5 1713 10 successfully successfully RB cord-006856-b1w25ob5 1713 11 performed perform VBN cord-006856-b1w25ob5 1713 12 in in IN cord-006856-b1w25ob5 1713 13 patients patient NNS cord-006856-b1w25ob5 1713 14 with with IN cord-006856-b1w25ob5 1713 15 otherwise otherwise RB cord-006856-b1w25ob5 1713 16 incurable incurable JJ cord-006856-b1w25ob5 1713 17 malignant malignant JJ cord-006856-b1w25ob5 1713 18 diseases disease NNS cord-006856-b1w25ob5 1713 19 . . . cord-006856-b1w25ob5 1714 1 However however RB cord-006856-b1w25ob5 1714 2 , , , cord-006856-b1w25ob5 1714 3 relapse relapse NN cord-006856-b1w25ob5 1714 4 after after IN cord-006856-b1w25ob5 1714 5 HSCT HSCT NNP cord-006856-b1w25ob5 1714 6 is be VBZ cord-006856-b1w25ob5 1714 7 one one CD cord-006856-b1w25ob5 1714 8 of of IN cord-006856-b1w25ob5 1714 9 the the DT cord-006856-b1w25ob5 1714 10 main main JJ cord-006856-b1w25ob5 1714 11 reasons reason NNS cord-006856-b1w25ob5 1714 12 for for IN cord-006856-b1w25ob5 1714 13 treatment treatment NN cord-006856-b1w25ob5 1714 14 failure failure NN cord-006856-b1w25ob5 1714 15 and and CC cord-006856-b1w25ob5 1714 16 further further JJ cord-006856-b1w25ob5 1714 17 therapeutic therapeutic JJ cord-006856-b1w25ob5 1714 18 strategies strategy NNS cord-006856-b1w25ob5 1714 19 with with IN cord-006856-b1w25ob5 1714 20 acceptable acceptable JJ cord-006856-b1w25ob5 1714 21 toxicity toxicity NN cord-006856-b1w25ob5 1714 22 are be VBP cord-006856-b1w25ob5 1714 23 warranted warrant VBN cord-006856-b1w25ob5 1714 24 . . . cord-006856-b1w25ob5 1715 1 Since since IN cord-006856-b1w25ob5 1715 2 myeloablative myeloablative NNP cord-006856-b1w25ob5 1715 3 ( ( -LRB- cord-006856-b1w25ob5 1715 4 MA MA NNP cord-006856-b1w25ob5 1715 5 ) ) -RRB- cord-006856-b1w25ob5 1715 6 conditioning conditioning NN cord-006856-b1w25ob5 1715 7 after after IN cord-006856-b1w25ob5 1715 8 prior prior JJ cord-006856-b1w25ob5 1715 9 HSCT HSCT NNP cord-006856-b1w25ob5 1715 10 has have VBZ cord-006856-b1w25ob5 1715 11 been be VBN cord-006856-b1w25ob5 1715 12 associated associate VBN cord-006856-b1w25ob5 1715 13 with with IN cord-006856-b1w25ob5 1715 14 high high JJ cord-006856-b1w25ob5 1715 15 treatment treatment NN cord-006856-b1w25ob5 1715 16 - - HYPH cord-006856-b1w25ob5 1715 17 related relate VBN cord-006856-b1w25ob5 1715 18 mortality mortality NN cord-006856-b1w25ob5 1715 19 ( ( -LRB- cord-006856-b1w25ob5 1715 20 TRM TRM NNP cord-006856-b1w25ob5 1715 21 ) ) -RRB- cord-006856-b1w25ob5 1715 22 , , . cord-006856-b1w25ob5 1716 1 reduced reduce VBN cord-006856-b1w25ob5 1716 2 - - HYPH cord-006856-b1w25ob5 1716 3 intensity intensity NN cord-006856-b1w25ob5 1716 4 conditioning conditioning NN cord-006856-b1w25ob5 1716 5 ( ( -LRB- cord-006856-b1w25ob5 1716 6 RIC RIC NNP cord-006856-b1w25ob5 1716 7 ) ) -RRB- cord-006856-b1w25ob5 1716 8 regimens regimen NNS cord-006856-b1w25ob5 1716 9 have have VBP cord-006856-b1w25ob5 1716 10 been be VBN cord-006856-b1w25ob5 1716 11 developed develop VBN cord-006856-b1w25ob5 1716 12 as as IN cord-006856-b1w25ob5 1716 13 salvage salvage NN cord-006856-b1w25ob5 1716 14 therapies therapy NNS cord-006856-b1w25ob5 1716 15 for for IN cord-006856-b1w25ob5 1716 16 these these DT cord-006856-b1w25ob5 1716 17 patients patient NNS cord-006856-b1w25ob5 1716 18 . . . cord-006856-b1w25ob5 1717 1 So so RB cord-006856-b1w25ob5 1717 2 far far RB cord-006856-b1w25ob5 1717 3 , , , cord-006856-b1w25ob5 1717 4 encouraging encourage VBG cord-006856-b1w25ob5 1717 5 results result NNS cord-006856-b1w25ob5 1717 6 have have VBP cord-006856-b1w25ob5 1717 7 been be VBN cord-006856-b1w25ob5 1717 8 achieved achieve VBN cord-006856-b1w25ob5 1717 9 with with IN cord-006856-b1w25ob5 1717 10 RIC RIC NNP cord-006856-b1w25ob5 1717 11 ; ; : cord-006856-b1w25ob5 1717 12 however however RB cord-006856-b1w25ob5 1717 13 , , , cord-006856-b1w25ob5 1717 14 a a DT cord-006856-b1w25ob5 1717 15 direct direct JJ cord-006856-b1w25ob5 1717 16 comparison comparison NN cord-006856-b1w25ob5 1717 17 with with IN cord-006856-b1w25ob5 1717 18 standard standard JJ cord-006856-b1w25ob5 1717 19 conditioning conditioning NN cord-006856-b1w25ob5 1717 20 has have VBZ cord-006856-b1w25ob5 1717 21 never never RB cord-006856-b1w25ob5 1717 22 been be VBN cord-006856-b1w25ob5 1717 23 performed perform VBN cord-006856-b1w25ob5 1717 24 . . . cord-006856-b1w25ob5 1718 1 Therefore therefore RB cord-006856-b1w25ob5 1718 2 , , , cord-006856-b1w25ob5 1718 3 we -PRON- PRP cord-006856-b1w25ob5 1718 4 retrospectively retrospectively RB cord-006856-b1w25ob5 1718 5 analysed analyse VBD cord-006856-b1w25ob5 1718 6 these these DT cord-006856-b1w25ob5 1718 7 two two CD cord-006856-b1w25ob5 1718 8 conditioning conditioning NN cord-006856-b1w25ob5 1718 9 strategies strategy NNS cord-006856-b1w25ob5 1718 10 in in IN cord-006856-b1w25ob5 1718 11 patients patient NNS cord-006856-b1w25ob5 1718 12 experiencing experience VBG cord-006856-b1w25ob5 1718 13 relapse relapse NN cord-006856-b1w25ob5 1718 14 after after IN cord-006856-b1w25ob5 1718 15 prior prior JJ cord-006856-b1w25ob5 1718 16 stem stem NN cord-006856-b1w25ob5 1718 17 cell cell NN cord-006856-b1w25ob5 1718 18 grafting grafting NN cord-006856-b1w25ob5 1718 19 . . . cord-006856-b1w25ob5 1719 1 Methods method NNS cord-006856-b1w25ob5 1719 2 . . . cord-006856-b1w25ob5 1720 1 We -PRON- PRP cord-006856-b1w25ob5 1720 2 analyzed analyze VBD cord-006856-b1w25ob5 1720 3 45 45 CD cord-006856-b1w25ob5 1720 4 patients patient NNS cord-006856-b1w25ob5 1720 5 with with IN cord-006856-b1w25ob5 1720 6 relapsed relapsed JJ cord-006856-b1w25ob5 1720 7 disease disease NN cord-006856-b1w25ob5 1720 8 ( ( -LRB- cord-006856-b1w25ob5 1720 9 acute acute JJ cord-006856-b1w25ob5 1720 10 myeloid myeloid NN cord-006856-b1w25ob5 1720 11 leukemia leukemia NN cord-006856-b1w25ob5 1720 12 , , , cord-006856-b1w25ob5 1720 13 n n NN cord-006856-b1w25ob5 1720 14 = = SYM cord-006856-b1w25ob5 1720 15 16 16 CD cord-006856-b1w25ob5 1720 16 ; ; , cord-006856-b1w25ob5 1720 17 indolent indolent JJ cord-006856-b1w25ob5 1720 18 lymphoma lymphoma NN cord-006856-b1w25ob5 1720 19 , , , cord-006856-b1w25ob5 1720 20 n n NN cord-006856-b1w25ob5 1720 21 = = SYM cord-006856-b1w25ob5 1720 22 9 9 CD cord-006856-b1w25ob5 1720 23 ; ; , cord-006856-b1w25ob5 1720 24 multiple multiple JJ cord-006856-b1w25ob5 1720 25 myeloma myeloma NN cord-006856-b1w25ob5 1720 26 , , , cord-006856-b1w25ob5 1720 27 n n NN cord-006856-b1w25ob5 1720 28 = = SYM cord-006856-b1w25ob5 1720 29 7 7 CD cord-006856-b1w25ob5 1720 30 ; ; , cord-006856-b1w25ob5 1720 31 chronic chronic JJ cord-006856-b1w25ob5 1720 32 myeloid myeloid NN cord-006856-b1w25ob5 1720 33 leukemia leukemia NN cord-006856-b1w25ob5 1720 34 , , , cord-006856-b1w25ob5 1720 35 n n NN cord-006856-b1w25ob5 1720 36 = = SYM cord-006856-b1w25ob5 1720 37 4 4 CD cord-006856-b1w25ob5 1720 38 ; ; , cord-006856-b1w25ob5 1720 39 myelodysplastic myelodysplastic JJ cord-006856-b1w25ob5 1720 40 syndrome syndrome NN cord-006856-b1w25ob5 1720 41 , , , cord-006856-b1w25ob5 1720 42 n n NN cord-006856-b1w25ob5 1720 43 = = SYM cord-006856-b1w25ob5 1720 44 2 2 CD cord-006856-b1w25ob5 1720 45 ; ; , cord-006856-b1w25ob5 1720 46 chronic chronic JJ cord-006856-b1w25ob5 1720 47 lymphocytic lymphocytic JJ cord-006856-b1w25ob5 1720 48 leukemia leukemia NN cord-006856-b1w25ob5 1720 49 , , , cord-006856-b1w25ob5 1720 50 n n NN cord-006856-b1w25ob5 1720 51 = = SYM cord-006856-b1w25ob5 1720 52 2 2 CD cord-006856-b1w25ob5 1720 53 ; ; , cord-006856-b1w25ob5 1720 54 acute acute JJ cord-006856-b1w25ob5 1720 55 lymphocytic lymphocytic JJ cord-006856-b1w25ob5 1720 56 leukaemia leukaemia NN cord-006856-b1w25ob5 1720 57 , , , cord-006856-b1w25ob5 1720 58 n n NN cord-006856-b1w25ob5 1720 59 = = SYM cord-006856-b1w25ob5 1720 60 2 2 CD cord-006856-b1w25ob5 1720 61 ; ; , cord-006856-b1w25ob5 1720 62 aggressive aggressive JJ cord-006856-b1w25ob5 1720 63 lymphoma lymphoma NN cord-006856-b1w25ob5 1720 64 , , , cord-006856-b1w25ob5 1720 65 n n NN cord-006856-b1w25ob5 1720 66 = = SYM cord-006856-b1w25ob5 1720 67 1 1 CD cord-006856-b1w25ob5 1720 68 ; ; : cord-006856-b1w25ob5 1720 69 Hodgkin Hodgkin NNP cord-006856-b1w25ob5 1720 70 's 's POS cord-006856-b1w25ob5 1720 71 disease disease NN cord-006856-b1w25ob5 1720 72 , , , cord-006856-b1w25ob5 1720 73 n n NN cord-006856-b1w25ob5 1720 74 = = SYM cord-006856-b1w25ob5 1720 75 1 1 CD cord-006856-b1w25ob5 1720 76 ; ; : cord-006856-b1w25ob5 1720 77 ovarian ovarian JJ cord-006856-b1w25ob5 1720 78 cancer cancer NN cord-006856-b1w25ob5 1720 79 , , , cord-006856-b1w25ob5 1720 80 n n NN cord-006856-b1w25ob5 1720 81 = = SYM cord-006856-b1w25ob5 1720 82 1 1 CD cord-006856-b1w25ob5 1720 83 ) ) -RRB- cord-006856-b1w25ob5 1721 1 after after IN cord-006856-b1w25ob5 1721 2 prior prior JJ cord-006856-b1w25ob5 1721 3 HSCT HSCT NNP cord-006856-b1w25ob5 1721 4 who who WP cord-006856-b1w25ob5 1721 5 received receive VBD cord-006856-b1w25ob5 1721 6 either either CC cord-006856-b1w25ob5 1721 7 reduced reduce VBN cord-006856-b1w25ob5 1721 8 - - HYPH cord-006856-b1w25ob5 1721 9 intensity intensity NN cord-006856-b1w25ob5 1721 10 or or CC cord-006856-b1w25ob5 1721 11 myeloablative myeloablative JJ cord-006856-b1w25ob5 1721 12 conditioning conditioning NN cord-006856-b1w25ob5 1721 13 for for IN cord-006856-b1w25ob5 1721 14 allogeneic allogeneic NN cord-006856-b1w25ob5 1721 15 HSCT HSCT NNP cord-006856-b1w25ob5 1721 16 between between IN cord-006856-b1w25ob5 1721 17 1986 1986 CD cord-006856-b1w25ob5 1721 18 and and CC cord-006856-b1w25ob5 1721 19 2005 2005 CD cord-006856-b1w25ob5 1721 20 . . . cord-006856-b1w25ob5 1722 1 RIC RIC NNP cord-006856-b1w25ob5 1722 2 consisted consist VBD cord-006856-b1w25ob5 1722 3 of of IN cord-006856-b1w25ob5 1722 4 fludarabine fludarabine NN cord-006856-b1w25ob5 1722 5 90 90 CD cord-006856-b1w25ob5 1722 6 mg mg NNP cord-006856-b1w25ob5 1722 7 / / SYM cord-006856-b1w25ob5 1722 8 m m NNP cord-006856-b1w25ob5 1722 9 2 2 CD cord-006856-b1w25ob5 1722 10 and and CC cord-006856-b1w25ob5 1722 11 total total JJ cord-006856-b1w25ob5 1722 12 - - HYPH cord-006856-b1w25ob5 1722 13 body body NN cord-006856-b1w25ob5 1722 14 irradiation irradiation NN cord-006856-b1w25ob5 1722 15 ( ( -LRB- cord-006856-b1w25ob5 1722 16 TBI TBI NNP cord-006856-b1w25ob5 1722 17 ) ) -RRB- cord-006856-b1w25ob5 1722 18 of of IN cord-006856-b1w25ob5 1722 19 2 2 CD cord-006856-b1w25ob5 1722 20 Gy Gy NNP cord-006856-b1w25ob5 1722 21 according accord VBG cord-006856-b1w25ob5 1722 22 to to IN cord-006856-b1w25ob5 1722 23 the the DT cord-006856-b1w25ob5 1722 24 Seattle Seattle NNP cord-006856-b1w25ob5 1722 25 protocol protocol NN cord-006856-b1w25ob5 1722 26 ( ( -LRB- cord-006856-b1w25ob5 1722 27 n n NN cord-006856-b1w25ob5 1722 28 = = SYM cord-006856-b1w25ob5 1722 29 18 18 CD cord-006856-b1w25ob5 1722 30 ) ) -RRB- cord-006856-b1w25ob5 1722 31 or or CC cord-006856-b1w25ob5 1722 32 alemtuzumab alemtuzumab VBN cord-006856-b1w25ob5 1722 33 in in IN cord-006856-b1w25ob5 1722 34 combination combination NN cord-006856-b1w25ob5 1722 35 with with IN cord-006856-b1w25ob5 1722 36 the the DT cord-006856-b1w25ob5 1722 37 BEAM BEAM NNP cord-006856-b1w25ob5 1722 38 regimen regimen NN cord-006856-b1w25ob5 1722 39 ( ( -LRB- cord-006856-b1w25ob5 1722 40 n n NN cord-006856-b1w25ob5 1722 41 = = SYM cord-006856-b1w25ob5 1722 42 1 1 CD cord-006856-b1w25ob5 1722 43 ) ) -RRB- cord-006856-b1w25ob5 1722 44 . . . cord-006856-b1w25ob5 1723 1 Myeloablative Myeloablative NNP cord-006856-b1w25ob5 1723 2 therapy therapy NN cord-006856-b1w25ob5 1723 3 consisted consist VBD cord-006856-b1w25ob5 1723 4 of of IN cord-006856-b1w25ob5 1723 5 cyclophosphamide cyclophosphamide NN cord-006856-b1w25ob5 1723 6 ( ( -LRB- cord-006856-b1w25ob5 1723 7 Cy Cy NNP cord-006856-b1w25ob5 1723 8 ) ) -RRB- cord-006856-b1w25ob5 1723 9 and and CC cord-006856-b1w25ob5 1723 10 TBI TBI NNP cord-006856-b1w25ob5 1723 11 of of IN cord-006856-b1w25ob5 1723 12 12 12 CD cord-006856-b1w25ob5 1723 13 to to TO cord-006856-b1w25ob5 1723 14 13 13 CD cord-006856-b1w25ob5 1723 15 Gy Gy NNP cord-006856-b1w25ob5 1723 16 ( ( -LRB- cord-006856-b1w25ob5 1723 17 n n NN cord-006856-b1w25ob5 1723 18 = = SYM cord-006856-b1w25ob5 1723 19 13 13 CD cord-006856-b1w25ob5 1723 20 ) ) -RRB- cord-006856-b1w25ob5 1723 21 , , , cord-006856-b1w25ob5 1723 22 Cy Cy NNP cord-006856-b1w25ob5 1723 23 plus plus CC cord-006856-b1w25ob5 1723 24 busulfan busulfan NN cord-006856-b1w25ob5 1723 25 ( ( -LRB- cord-006856-b1w25ob5 1723 26 Bu Bu NNP cord-006856-b1w25ob5 1723 27 ) ) -RRB- cord-006856-b1w25ob5 1724 1 ( ( -LRB- cord-006856-b1w25ob5 1724 2 n n NN cord-006856-b1w25ob5 1724 3 = = SYM cord-006856-b1w25ob5 1724 4 4 4 CD cord-006856-b1w25ob5 1724 5 ) ) -RRB- cord-006856-b1w25ob5 1724 6 , , , cord-006856-b1w25ob5 1724 7 C C NNP cord-006856-b1w25ob5 1724 8 plus plus CC cord-006856-b1w25ob5 1724 9 antithymocyte antithymocyte NNP cord-006856-b1w25ob5 1724 10 globulin globulin NN cord-006856-b1w25ob5 1724 11 plus plus CC cord-006856-b1w25ob5 1724 12 Bu Bu NNP cord-006856-b1w25ob5 1724 13 ( ( -LRB- cord-006856-b1w25ob5 1724 14 n n NN cord-006856-b1w25ob5 1724 15 = = SYM cord-006856-b1w25ob5 1724 16 2 2 CD cord-006856-b1w25ob5 1724 17 ) ) -RRB- cord-006856-b1w25ob5 1724 18 , , , cord-006856-b1w25ob5 1724 19 or or CC cord-006856-b1w25ob5 1724 20 Bu Bu NNP cord-006856-b1w25ob5 1724 21 alone alone RB cord-006856-b1w25ob5 1725 1 ( ( -LRB- cord-006856-b1w25ob5 1725 2 n n NN cord-006856-b1w25ob5 1725 3 = = SYM cord-006856-b1w25ob5 1725 4 7 7 CD cord-006856-b1w25ob5 1725 5 ) ) -RRB- cord-006856-b1w25ob5 1725 6 . . . cord-006856-b1w25ob5 1726 1 Donors donor NNS cord-006856-b1w25ob5 1726 2 were be VBD cord-006856-b1w25ob5 1726 3 syngeneic syngeneic NNS cord-006856-b1w25ob5 1726 4 in in IN cord-006856-b1w25ob5 1726 5 4 4 CD cord-006856-b1w25ob5 1726 6 , , , cord-006856-b1w25ob5 1726 7 related relate VBN cord-006856-b1w25ob5 1726 8 in in IN cord-006856-b1w25ob5 1726 9 21 21 CD cord-006856-b1w25ob5 1726 10 , , , cord-006856-b1w25ob5 1726 11 and and CC cord-006856-b1w25ob5 1726 12 unrelated unrelated JJ cord-006856-b1w25ob5 1726 13 in in IN cord-006856-b1w25ob5 1726 14 20 20 CD cord-006856-b1w25ob5 1726 15 patients patient NNS cord-006856-b1w25ob5 1726 16 . . . cord-006856-b1w25ob5 1727 1 Stem stem JJ cord-006856-b1w25ob5 1727 2 cell cell NN cord-006856-b1w25ob5 1727 3 source source NN cord-006856-b1w25ob5 1727 4 was be VBD cord-006856-b1w25ob5 1727 5 bone bone NN cord-006856-b1w25ob5 1727 6 marrow marrow NN cord-006856-b1w25ob5 1727 7 in in IN cord-006856-b1w25ob5 1727 8 13 13 CD cord-006856-b1w25ob5 1727 9 ( ( -LRB- cord-006856-b1w25ob5 1727 10 29 29 CD cord-006856-b1w25ob5 1727 11 % % NN cord-006856-b1w25ob5 1727 12 ) ) -RRB- cord-006856-b1w25ob5 1727 13 and and CC cord-006856-b1w25ob5 1727 14 peripheral peripheral JJ cord-006856-b1w25ob5 1727 15 blood blood NN cord-006856-b1w25ob5 1727 16 in in IN cord-006856-b1w25ob5 1727 17 32 32 CD cord-006856-b1w25ob5 1727 18 ( ( -LRB- cord-006856-b1w25ob5 1727 19 71 71 CD cord-006856-b1w25ob5 1727 20 % % NN cord-006856-b1w25ob5 1727 21 ) ) -RRB- cord-006856-b1w25ob5 1727 22 patients patient NNS cord-006856-b1w25ob5 1727 23 . . . cord-006856-b1w25ob5 1728 1 For for IN cord-006856-b1w25ob5 1728 2 graft graft NN cord-006856-b1w25ob5 1728 3 - - HYPH cord-006856-b1w25ob5 1728 4 versus versus IN cord-006856-b1w25ob5 1728 5 - - HYPH cord-006856-b1w25ob5 1728 6 host host NN cord-006856-b1w25ob5 1728 7 disease disease NN cord-006856-b1w25ob5 1728 8 ( ( -LRB- cord-006856-b1w25ob5 1728 9 GvHD GvHD NNP cord-006856-b1w25ob5 1728 10 ) ) -RRB- cord-006856-b1w25ob5 1728 11 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1728 12 , , , cord-006856-b1w25ob5 1728 13 22 22 CD cord-006856-b1w25ob5 1728 14 patients patient NNS cord-006856-b1w25ob5 1728 15 received receive VBD cord-006856-b1w25ob5 1728 16 cyclosporine cyclosporine NN cord-006856-b1w25ob5 1728 17 A a NN cord-006856-b1w25ob5 1728 18 ( ( -LRB- cord-006856-b1w25ob5 1728 19 CSA CSA NNP cord-006856-b1w25ob5 1728 20 ) ) -RRB- cord-006856-b1w25ob5 1728 21 plus plus CC cord-006856-b1w25ob5 1728 22 mycophenolate mycophenolate NNP cord-006856-b1w25ob5 1728 23 mofetil mofetil NNP cord-006856-b1w25ob5 1728 24 , , , cord-006856-b1w25ob5 1728 25 16 16 CD cord-006856-b1w25ob5 1728 26 CSA CSA NNP cord-006856-b1w25ob5 1728 27 plus plus CC cord-006856-b1w25ob5 1728 28 methotrexate methotrexate NNP cord-006856-b1w25ob5 1728 29 , , , cord-006856-b1w25ob5 1728 30 2 2 CD cord-006856-b1w25ob5 1728 31 MTX MTX NNP cord-006856-b1w25ob5 1728 32 alone alone RB cord-006856-b1w25ob5 1728 33 , , , cord-006856-b1w25ob5 1728 34 and and CC cord-006856-b1w25ob5 1728 35 1 1 CD cord-006856-b1w25ob5 1728 36 CSA CSA NNP cord-006856-b1w25ob5 1728 37 alone alone RB cord-006856-b1w25ob5 1728 38 . . . cord-006856-b1w25ob5 1729 1 Results result NNS cord-006856-b1w25ob5 1729 2 . . . cord-006856-b1w25ob5 1730 1 All all DT cord-006856-b1w25ob5 1730 2 patients patient NNS cord-006856-b1w25ob5 1730 3 achieved achieve VBD cord-006856-b1w25ob5 1730 4 complete complete JJ cord-006856-b1w25ob5 1730 5 hematopoietic hematopoietic JJ cord-006856-b1w25ob5 1730 6 engraftment engraftment NN cord-006856-b1w25ob5 1730 7 by by IN cord-006856-b1w25ob5 1730 8 day day NN cord-006856-b1w25ob5 1730 9 28 28 CD cord-006856-b1w25ob5 1730 10 after after IN cord-006856-b1w25ob5 1730 11 stem stem NN cord-006856-b1w25ob5 1730 12 cell cell NN cord-006856-b1w25ob5 1730 13 transplantation transplantation NN cord-006856-b1w25ob5 1730 14 with with IN cord-006856-b1w25ob5 1730 15 complete complete JJ cord-006856-b1w25ob5 1730 16 donor donor NN cord-006856-b1w25ob5 1730 17 chimerism chimerism NN cord-006856-b1w25ob5 1730 18 . . . cord-006856-b1w25ob5 1731 1 All all DT cord-006856-b1w25ob5 1731 2 patients patient NNS cord-006856-b1w25ob5 1731 3 conditioned condition VBN cord-006856-b1w25ob5 1731 4 with with IN cord-006856-b1w25ob5 1731 5 RIC RIC NNP cord-006856-b1w25ob5 1731 6 presented present VBD cord-006856-b1w25ob5 1731 7 complete complete JJ cord-006856-b1w25ob5 1731 8 donor donor NN cord-006856-b1w25ob5 1731 9 chimerism chimerism NN cord-006856-b1w25ob5 1731 10 of of IN cord-006856-b1w25ob5 1731 11 T t NN cord-006856-b1w25ob5 1731 12 cells cell NNS cord-006856-b1w25ob5 1731 13 , , , cord-006856-b1w25ob5 1731 14 myeloid myeloid JJ cord-006856-b1w25ob5 1731 15 progenitor progenitor NN cord-006856-b1w25ob5 1731 16 cells cell NNS cord-006856-b1w25ob5 1731 17 , , , cord-006856-b1w25ob5 1731 18 and and CC cord-006856-b1w25ob5 1731 19 NK NK NNP cord-006856-b1w25ob5 1731 20 cells cell VBZ cord-006856-b1w25ob5 1731 21 28 28 CD cord-006856-b1w25ob5 1731 22 to to TO cord-006856-b1w25ob5 1731 23 81 81 CD cord-006856-b1w25ob5 1731 24 days day NNS cord-006856-b1w25ob5 1731 25 after after IN cord-006856-b1w25ob5 1731 26 HSCT HSCT NNP cord-006856-b1w25ob5 1731 27 . . . cord-006856-b1w25ob5 1732 1 The the DT cord-006856-b1w25ob5 1732 2 in in NN cord-006856-b1w25ob5 1732 3 - - HYPH cord-006856-b1w25ob5 1732 4 cidence cidence NN cord-006856-b1w25ob5 1732 5 of of IN cord-006856-b1w25ob5 1732 6 acute acute JJ cord-006856-b1w25ob5 1732 7 GVHD GVHD NNP cord-006856-b1w25ob5 1732 8 was be VBD cord-006856-b1w25ob5 1732 9 37 37 CD cord-006856-b1w25ob5 1732 10 % % NN cord-006856-b1w25ob5 1732 11 and and CC cord-006856-b1w25ob5 1732 12 comparable comparable JJ cord-006856-b1w25ob5 1732 13 in in IN cord-006856-b1w25ob5 1732 14 both both DT cord-006856-b1w25ob5 1732 15 groups group NNS cord-006856-b1w25ob5 1732 16 consisting consist VBG cord-006856-b1w25ob5 1732 17 of of IN cord-006856-b1w25ob5 1732 18 grade grade NN cord-006856-b1w25ob5 1732 19 I -PRON- PRP cord-006856-b1w25ob5 1732 20 in in IN cord-006856-b1w25ob5 1732 21 6 6 CD cord-006856-b1w25ob5 1732 22 patients patient NNS cord-006856-b1w25ob5 1732 23 , , , cord-006856-b1w25ob5 1732 24 grade grade NN cord-006856-b1w25ob5 1732 25 II II NNP cord-006856-b1w25ob5 1732 26 in in IN cord-006856-b1w25ob5 1732 27 3 3 CD cord-006856-b1w25ob5 1732 28 , , , cord-006856-b1w25ob5 1732 29 grade grade NN cord-006856-b1w25ob5 1732 30 III III NNP cord-006856-b1w25ob5 1732 31 in in IN cord-006856-b1w25ob5 1732 32 6 6 CD cord-006856-b1w25ob5 1732 33 , , , cord-006856-b1w25ob5 1732 34 and and CC cord-006856-b1w25ob5 1732 35 grade grade NN cord-006856-b1w25ob5 1732 36 IV IV NNP cord-006856-b1w25ob5 1732 37 in in IN cord-006856-b1w25ob5 1732 38 2 2 CD cord-006856-b1w25ob5 1732 39 . . . cord-006856-b1w25ob5 1733 1 Fourteen fourteen CD cord-006856-b1w25ob5 1733 2 patients patient NNS cord-006856-b1w25ob5 1733 3 died die VBD cord-006856-b1w25ob5 1733 4 after after IN cord-006856-b1w25ob5 1733 5 MA MA NNP cord-006856-b1w25ob5 1733 6 conditioning conditioning NN cord-006856-b1w25ob5 1733 7 of of IN cord-006856-b1w25ob5 1733 8 acute acute JJ cord-006856-b1w25ob5 1733 9 GvHD GvHD NNP cord-006856-b1w25ob5 1733 10 ( ( -LRB- cord-006856-b1w25ob5 1733 11 n n NN cord-006856-b1w25ob5 1733 12 = = SYM cord-006856-b1w25ob5 1733 13 2 2 CD cord-006856-b1w25ob5 1733 14 ) ) -RRB- cord-006856-b1w25ob5 1733 15 , , , cord-006856-b1w25ob5 1733 16 infections infection NNS cord-006856-b1w25ob5 1733 17 ( ( -LRB- cord-006856-b1w25ob5 1733 18 n n NN cord-006856-b1w25ob5 1733 19 = = SYM cord-006856-b1w25ob5 1733 20 5 5 CD cord-006856-b1w25ob5 1733 21 ) ) -RRB- cord-006856-b1w25ob5 1733 22 , , , cord-006856-b1w25ob5 1733 23 or or CC cord-006856-b1w25ob5 1733 24 severe severe JJ cord-006856-b1w25ob5 1733 25 toxicity toxicity NN cord-006856-b1w25ob5 1733 26 ( ( -LRB- cord-006856-b1w25ob5 1733 27 n n NN cord-006856-b1w25ob5 1733 28 = = SYM cord-006856-b1w25ob5 1733 29 7 7 CD cord-006856-b1w25ob5 1733 30 ) ) -RRB- cord-006856-b1w25ob5 1733 31 , , , cord-006856-b1w25ob5 1733 32 while while IN cord-006856-b1w25ob5 1733 33 only only RB cord-006856-b1w25ob5 1733 34 one one CD cord-006856-b1w25ob5 1733 35 patient patient NN cord-006856-b1w25ob5 1733 36 died die VBD cord-006856-b1w25ob5 1733 37 due due IN cord-006856-b1w25ob5 1733 38 to to IN cord-006856-b1w25ob5 1733 39 infection infection NN cord-006856-b1w25ob5 1733 40 after after IN cord-006856-b1w25ob5 1733 41 RIC RIC NNP cord-006856-b1w25ob5 1733 42 . . . cord-006856-b1w25ob5 1734 1 Probability probability NN cord-006856-b1w25ob5 1734 2 of of IN cord-006856-b1w25ob5 1734 3 transplant transplant NN cord-006856-b1w25ob5 1734 4 - - HYPH cord-006856-b1w25ob5 1734 5 related relate VBN cord-006856-b1w25ob5 1734 6 mortality mortality NN cord-006856-b1w25ob5 1734 7 ( ( -LRB- cord-006856-b1w25ob5 1734 8 TRM TRM NNP cord-006856-b1w25ob5 1734 9 ) ) -RRB- cord-006856-b1w25ob5 1734 10 at at IN cord-006856-b1w25ob5 1734 11 1 1 CD cord-006856-b1w25ob5 1734 12 year year NN cord-006856-b1w25ob5 1734 13 after after IN cord-006856-b1w25ob5 1734 14 HSCT HSCT NNP cord-006856-b1w25ob5 1734 15 was be VBD cord-006856-b1w25ob5 1734 16 with with IN cord-006856-b1w25ob5 1734 17 54 54 CD cord-006856-b1w25ob5 1734 18 % % NN cord-006856-b1w25ob5 1734 19 significantly significantly RB cord-006856-b1w25ob5 1734 20 ( ( -LRB- cord-006856-b1w25ob5 1734 21 P p NN cord-006856-b1w25ob5 1734 22 = = SYM cord-006856-b1w25ob5 1734 23 0.001 0.001 CD cord-006856-b1w25ob5 1734 24 ) ) -RRB- cord-006856-b1w25ob5 1734 25 higher high JJR cord-006856-b1w25ob5 1734 26 in in IN cord-006856-b1w25ob5 1734 27 patients patient NNS cord-006856-b1w25ob5 1734 28 given give VBN cord-006856-b1w25ob5 1734 29 myeloablative myeloablative JJ cord-006856-b1w25ob5 1734 30 conditioning conditioning NN cord-006856-b1w25ob5 1734 31 compared compare VBN cord-006856-b1w25ob5 1734 32 to to IN cord-006856-b1w25ob5 1734 33 5 5 CD cord-006856-b1w25ob5 1734 34 % % NN cord-006856-b1w25ob5 1734 35 after after IN cord-006856-b1w25ob5 1734 36 RIC RIC NNP cord-006856-b1w25ob5 1734 37 . . . cord-006856-b1w25ob5 1735 1 Incidence incidence NN cord-006856-b1w25ob5 1735 2 of of IN cord-006856-b1w25ob5 1735 3 therapy therapy NN cord-006856-b1w25ob5 1735 4 requiring require VBG cord-006856-b1w25ob5 1735 5 chronic chronic JJ cord-006856-b1w25ob5 1735 6 GvHD GvHD NNP cord-006856-b1w25ob5 1735 7 was be VBD cord-006856-b1w25ob5 1735 8 with with IN cord-006856-b1w25ob5 1735 9 64 64 CD cord-006856-b1w25ob5 1735 10 % % NN cord-006856-b1w25ob5 1735 11 versus versus IN cord-006856-b1w25ob5 1735 12 33 33 CD cord-006856-b1w25ob5 1735 13 % % NN cord-006856-b1w25ob5 1735 14 significantly significantly RB cord-006856-b1w25ob5 1735 15 ( ( -LRB- cord-006856-b1w25ob5 1735 16 P p NN cord-006856-b1w25ob5 1735 17 = = SYM cord-006856-b1w25ob5 1735 18 0.001 0.001 CD cord-006856-b1w25ob5 1735 19 ) ) -RRB- cord-006856-b1w25ob5 1735 20 higher high JJR cord-006856-b1w25ob5 1735 21 in in IN cord-006856-b1w25ob5 1735 22 patients patient NNS cord-006856-b1w25ob5 1735 23 who who WP cord-006856-b1w25ob5 1735 24 received receive VBD cord-006856-b1w25ob5 1735 25 RIC RIC NNP cord-006856-b1w25ob5 1735 26 . . . cord-006856-b1w25ob5 1736 1 Response response NN cord-006856-b1w25ob5 1736 2 rates rate NNS cord-006856-b1w25ob5 1736 3 were be VBD cord-006856-b1w25ob5 1736 4 comparable comparable JJ cord-006856-b1w25ob5 1736 5 between between IN cord-006856-b1w25ob5 1736 6 patients patient NNS cord-006856-b1w25ob5 1736 7 who who WP cord-006856-b1w25ob5 1736 8 received receive VBD cord-006856-b1w25ob5 1736 9 RIC RIC NNP cord-006856-b1w25ob5 1736 10 or or CC cord-006856-b1w25ob5 1736 11 MA MA NNP cord-006856-b1w25ob5 1736 12 conditioning conditioning NN cord-006856-b1w25ob5 1736 13 ( ( -LRB- cord-006856-b1w25ob5 1736 14 90 90 CD cord-006856-b1w25ob5 1736 15 % % NN cord-006856-b1w25ob5 1736 16 versus versus IN cord-006856-b1w25ob5 1736 17 100 100 CD cord-006856-b1w25ob5 1736 18 % % NN cord-006856-b1w25ob5 1736 19 ) ) -RRB- cord-006856-b1w25ob5 1736 20 . . . cord-006856-b1w25ob5 1737 1 Relapses relapse NNS cord-006856-b1w25ob5 1737 2 occurred occur VBD cord-006856-b1w25ob5 1737 3 in in IN cord-006856-b1w25ob5 1737 4 37 37 CD cord-006856-b1w25ob5 1737 5 % % NN cord-006856-b1w25ob5 1737 6 of of IN cord-006856-b1w25ob5 1737 7 patients patient NNS cord-006856-b1w25ob5 1737 8 after after IN cord-006856-b1w25ob5 1737 9 RIC RIC NNP cord-006856-b1w25ob5 1737 10 and and CC cord-006856-b1w25ob5 1737 11 32 32 CD cord-006856-b1w25ob5 1737 12 % % NN cord-006856-b1w25ob5 1737 13 after after IN cord-006856-b1w25ob5 1737 14 MA MA NNP cord-006856-b1w25ob5 1737 15 conditioning conditioning NN cord-006856-b1w25ob5 1737 16 . . . cord-006856-b1w25ob5 1738 1 After after IN cord-006856-b1w25ob5 1738 2 a a DT cord-006856-b1w25ob5 1738 3 median median JJ cord-006856-b1w25ob5 1738 4 follow follow NN cord-006856-b1w25ob5 1738 5 - - HYPH cord-006856-b1w25ob5 1738 6 up up NN cord-006856-b1w25ob5 1738 7 of of IN cord-006856-b1w25ob5 1738 8 44.5 44.5 CD cord-006856-b1w25ob5 1738 9 ( ( -LRB- cord-006856-b1w25ob5 1738 10 range range NN cord-006856-b1w25ob5 1738 11 , , , cord-006856-b1w25ob5 1738 12 8 8 CD cord-006856-b1w25ob5 1738 13 - - SYM cord-006856-b1w25ob5 1738 14 204 204 CD cord-006856-b1w25ob5 1738 15 ) ) -RRB- cord-006856-b1w25ob5 1738 16 months month NNS cord-006856-b1w25ob5 1738 17 3 3 CD cord-006856-b1w25ob5 1738 18 ( ( -LRB- cord-006856-b1w25ob5 1738 19 11 11 CD cord-006856-b1w25ob5 1738 20 % % NN cord-006856-b1w25ob5 1738 21 ) ) -RRB- cord-006856-b1w25ob5 1738 22 of of IN cord-006856-b1w25ob5 1738 23 patients patient NNS cord-006856-b1w25ob5 1738 24 of of IN cord-006856-b1w25ob5 1738 25 the the DT cord-006856-b1w25ob5 1738 26 MA MA NNP cord-006856-b1w25ob5 1738 27 group group NN cord-006856-b1w25ob5 1738 28 and and CC cord-006856-b1w25ob5 1738 29 11 11 CD cord-006856-b1w25ob5 1738 30 ( ( -LRB- cord-006856-b1w25ob5 1738 31 58 58 CD cord-006856-b1w25ob5 1738 32 % % NN cord-006856-b1w25ob5 1738 33 ) ) -RRB- cord-006856-b1w25ob5 1738 34 of of IN cord-006856-b1w25ob5 1738 35 the the DT cord-006856-b1w25ob5 1738 36 RIC RIC NNP cord-006856-b1w25ob5 1738 37 group group NN cord-006856-b1w25ob5 1738 38 are be VBP cord-006856-b1w25ob5 1738 39 currently currently RB cord-006856-b1w25ob5 1738 40 alive alive JJ cord-006856-b1w25ob5 1738 41 . . . cord-006856-b1w25ob5 1739 1 Probability probability NN cord-006856-b1w25ob5 1739 2 of of IN cord-006856-b1w25ob5 1739 3 survival survival NN cord-006856-b1w25ob5 1739 4 at at IN cord-006856-b1w25ob5 1739 5 1 1 CD cord-006856-b1w25ob5 1739 6 and and CC cord-006856-b1w25ob5 1739 7 4 4 CD cord-006856-b1w25ob5 1739 8 years year NNS cord-006856-b1w25ob5 1739 9 after after IN cord-006856-b1w25ob5 1739 10 HSCT HSCT NNP cord-006856-b1w25ob5 1739 11 is be VBZ cord-006856-b1w25ob5 1739 12 with with IN cord-006856-b1w25ob5 1739 13 73 73 CD cord-006856-b1w25ob5 1739 14 % % NN cord-006856-b1w25ob5 1739 15 versus versus IN cord-006856-b1w25ob5 1739 16 24 24 CD cord-006856-b1w25ob5 1739 17 % % NN cord-006856-b1w25ob5 1739 18 and and CC cord-006856-b1w25ob5 1739 19 48 48 CD cord-006856-b1w25ob5 1739 20 % % NN cord-006856-b1w25ob5 1739 21 versus versus IN cord-006856-b1w25ob5 1739 22 12 12 CD cord-006856-b1w25ob5 1739 23 % % NN cord-006856-b1w25ob5 1739 24 significantly significantly RB cord-006856-b1w25ob5 1739 25 ( ( -LRB- cord-006856-b1w25ob5 1739 26 P p NN cord-006856-b1w25ob5 1739 27 = = SYM cord-006856-b1w25ob5 1739 28 0.008 0.008 CD cord-006856-b1w25ob5 1739 29 ) ) -RRB- cord-006856-b1w25ob5 1739 30 higher high JJR cord-006856-b1w25ob5 1739 31 after after IN cord-006856-b1w25ob5 1739 32 RIC RIC NNP cord-006856-b1w25ob5 1739 33 than than IN cord-006856-b1w25ob5 1739 34 after after IN cord-006856-b1w25ob5 1739 35 myeloablative myeloablative NNP cord-006856-b1w25ob5 1739 36 conditioning conditioning NNP cord-006856-b1w25ob5 1739 37 . . . cord-006856-b1w25ob5 1740 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1740 2 . . . cord-006856-b1w25ob5 1741 1 Allogeneic allogeneic IN cord-006856-b1w25ob5 1741 2 stem stem VBP cord-006856-b1w25ob5 1741 3 cell cell NN cord-006856-b1w25ob5 1741 4 transplantation transplantation NN cord-006856-b1w25ob5 1741 5 is be VBZ cord-006856-b1w25ob5 1741 6 a a DT cord-006856-b1w25ob5 1741 7 highly highly RB cord-006856-b1w25ob5 1741 8 effective effective JJ cord-006856-b1w25ob5 1741 9 treatment treatment NN cord-006856-b1w25ob5 1741 10 option option NN cord-006856-b1w25ob5 1741 11 in in IN cord-006856-b1w25ob5 1741 12 patients patient NNS cord-006856-b1w25ob5 1741 13 relapsing relapse VBG cord-006856-b1w25ob5 1741 14 after after IN cord-006856-b1w25ob5 1741 15 prior prior JJ cord-006856-b1w25ob5 1741 16 HSCT HSCT NNP cord-006856-b1w25ob5 1741 17 . . . cord-006856-b1w25ob5 1742 1 Durable durable JJ cord-006856-b1w25ob5 1742 2 hematologic hematologic JJ cord-006856-b1w25ob5 1742 3 engraftment engraftment NN cord-006856-b1w25ob5 1742 4 and and CC cord-006856-b1w25ob5 1742 5 sustained sustain VBD cord-006856-b1w25ob5 1742 6 complete complete JJ cord-006856-b1w25ob5 1742 7 remissions remission NNS cord-006856-b1w25ob5 1742 8 can can MD cord-006856-b1w25ob5 1742 9 be be VB cord-006856-b1w25ob5 1742 10 achieved achieve VBN cord-006856-b1w25ob5 1742 11 in in IN cord-006856-b1w25ob5 1742 12 patients patient NNS cord-006856-b1w25ob5 1742 13 with with IN cord-006856-b1w25ob5 1742 14 otherwise otherwise RB cord-006856-b1w25ob5 1742 15 poor poor JJ cord-006856-b1w25ob5 1742 16 prognosis prognosis NN cord-006856-b1w25ob5 1742 17 . . . cord-006856-b1w25ob5 1743 1 Since since IN cord-006856-b1w25ob5 1743 2 transplant transplant NN cord-006856-b1w25ob5 1743 3 - - HYPH cord-006856-b1w25ob5 1743 4 related relate VBN cord-006856-b1w25ob5 1743 5 mortality mortality NN cord-006856-b1w25ob5 1743 6 of of IN cord-006856-b1w25ob5 1743 7 dose dose NN cord-006856-b1w25ob5 1743 8 - - HYPH cord-006856-b1w25ob5 1743 9 reduced reduce VBN cord-006856-b1w25ob5 1743 10 conditioning conditioning NN cord-006856-b1w25ob5 1743 11 is be VBZ cord-006856-b1w25ob5 1743 12 in in IN cord-006856-b1w25ob5 1743 13 comparison comparison NN cord-006856-b1w25ob5 1743 14 to to TO cord-006856-b1w25ob5 1743 15 myeloablative myeloablative NNP cord-006856-b1w25ob5 1743 16 HSCT HSCT NNP cord-006856-b1w25ob5 1743 17 considerably considerably RB cord-006856-b1w25ob5 1743 18 lower lower RBR cord-006856-b1w25ob5 1743 19 , , , cord-006856-b1w25ob5 1743 20 overall overall JJ cord-006856-b1w25ob5 1743 21 survival survival NN cord-006856-b1w25ob5 1743 22 can can MD cord-006856-b1w25ob5 1743 23 be be VB cord-006856-b1w25ob5 1743 24 significantly significantly RB cord-006856-b1w25ob5 1743 25 improved improve VBN cord-006856-b1w25ob5 1743 26 with with IN cord-006856-b1w25ob5 1743 27 this this DT cord-006856-b1w25ob5 1743 28 new new JJ cord-006856-b1w25ob5 1743 29 treatment treatment NN cord-006856-b1w25ob5 1743 30 modality modality NN cord-006856-b1w25ob5 1743 31 . . . cord-006856-b1w25ob5 1744 1 Background background NN cord-006856-b1w25ob5 1744 2 . . . cord-006856-b1w25ob5 1745 1 Patients patient NNS cord-006856-b1w25ob5 1745 2 with with IN cord-006856-b1w25ob5 1745 3 comorbidities comorbiditie NNS cord-006856-b1w25ob5 1745 4 such such JJ cord-006856-b1w25ob5 1745 5 as as IN cord-006856-b1w25ob5 1745 6 organ organ NN cord-006856-b1w25ob5 1745 7 dysfunctions dysfunction NNS cord-006856-b1w25ob5 1745 8 or or CC cord-006856-b1w25ob5 1745 9 preexisting preexist VBG cord-006856-b1w25ob5 1745 10 infections infection NNS cord-006856-b1w25ob5 1745 11 experience experience VBP cord-006856-b1w25ob5 1745 12 a a DT cord-006856-b1w25ob5 1745 13 high high JJ cord-006856-b1w25ob5 1745 14 treatment treatment NN cord-006856-b1w25ob5 1745 15 - - HYPH cord-006856-b1w25ob5 1745 16 related relate VBN cord-006856-b1w25ob5 1745 17 mortality mortality NN cord-006856-b1w25ob5 1745 18 which which WDT cord-006856-b1w25ob5 1745 19 makes make VBZ cord-006856-b1w25ob5 1745 20 them -PRON- PRP cord-006856-b1w25ob5 1745 21 ineligible ineligible JJ cord-006856-b1w25ob5 1745 22 for for IN cord-006856-b1w25ob5 1745 23 conventional conventional JJ cord-006856-b1w25ob5 1745 24 conditioning conditioning NN cord-006856-b1w25ob5 1745 25 therapy therapy NN cord-006856-b1w25ob5 1745 26 . . . cord-006856-b1w25ob5 1746 1 For for IN cord-006856-b1w25ob5 1746 2 these these DT cord-006856-b1w25ob5 1746 3 patients patient NNS cord-006856-b1w25ob5 1746 4 , , , cord-006856-b1w25ob5 1746 5 reduced reduce VBN cord-006856-b1w25ob5 1746 6 - - HYPH cord-006856-b1w25ob5 1746 7 intensity intensity NN cord-006856-b1w25ob5 1746 8 conditioning conditioning NN cord-006856-b1w25ob5 1746 9 ( ( -LRB- cord-006856-b1w25ob5 1746 10 RIC RIC NNP cord-006856-b1w25ob5 1746 11 ) ) -RRB- cord-006856-b1w25ob5 1746 12 is be VBZ cord-006856-b1w25ob5 1746 13 an an DT cord-006856-b1w25ob5 1746 14 option option NN cord-006856-b1w25ob5 1746 15 which which WDT cord-006856-b1w25ob5 1746 16 offers offer VBZ cord-006856-b1w25ob5 1746 17 the the DT cord-006856-b1w25ob5 1746 18 benefits benefit NNS cord-006856-b1w25ob5 1746 19 of of IN cord-006856-b1w25ob5 1746 20 an an DT cord-006856-b1w25ob5 1746 21 allogeneic allogeneic NN cord-006856-b1w25ob5 1746 22 transplant transplant NN cord-006856-b1w25ob5 1746 23 with with IN cord-006856-b1w25ob5 1746 24 lower low JJR cord-006856-b1w25ob5 1746 25 extramedullary extramedullary JJ cord-006856-b1w25ob5 1746 26 toxicity toxicity NN cord-006856-b1w25ob5 1746 27 . . . cord-006856-b1w25ob5 1747 1 We -PRON- PRP cord-006856-b1w25ob5 1747 2 report report VBP cord-006856-b1w25ob5 1747 3 on on IN cord-006856-b1w25ob5 1747 4 8 8 CD cord-006856-b1w25ob5 1747 5 pediatric pediatric JJ cord-006856-b1w25ob5 1747 6 and and CC cord-006856-b1w25ob5 1747 7 young young JJ cord-006856-b1w25ob5 1747 8 adult adult NN cord-006856-b1w25ob5 1747 9 patients patient NNS cord-006856-b1w25ob5 1747 10 who who WP cord-006856-b1w25ob5 1747 11 were be VBD cord-006856-b1w25ob5 1747 12 considered consider VBN cord-006856-b1w25ob5 1747 13 for for IN cord-006856-b1w25ob5 1747 14 RIC RIC NNP cord-006856-b1w25ob5 1747 15 because because IN cord-006856-b1w25ob5 1747 16 of of IN cord-006856-b1w25ob5 1747 17 severe severe JJ cord-006856-b1w25ob5 1747 18 cumulative cumulative JJ cord-006856-b1w25ob5 1747 19 pretreatment pretreatment NN cord-006856-b1w25ob5 1747 20 or or CC cord-006856-b1w25ob5 1747 21 substantial substantial JJ cord-006856-b1w25ob5 1747 22 comorbidities comorbiditie NNS cord-006856-b1w25ob5 1747 23 treated treat VBN cord-006856-b1w25ob5 1747 24 at at IN cord-006856-b1w25ob5 1747 25 our -PRON- PRP$ cord-006856-b1w25ob5 1747 26 institution institution NN cord-006856-b1w25ob5 1747 27 between between IN cord-006856-b1w25ob5 1747 28 2001 2001 CD cord-006856-b1w25ob5 1747 29 and and CC cord-006856-b1w25ob5 1747 30 2005 2005 CD cord-006856-b1w25ob5 1747 31 . . . cord-006856-b1w25ob5 1748 1 Methods method NNS cord-006856-b1w25ob5 1748 2 . . . cord-006856-b1w25ob5 1749 1 Eight eight CD cord-006856-b1w25ob5 1749 2 patients patient NNS cord-006856-b1w25ob5 1749 3 ( ( -LRB- cord-006856-b1w25ob5 1749 4 median median JJ cord-006856-b1w25ob5 1749 5 age age NN cord-006856-b1w25ob5 1749 6 , , , cord-006856-b1w25ob5 1749 7 11 11 CD cord-006856-b1w25ob5 1749 8 years year NNS cord-006856-b1w25ob5 1749 9 ; ; : cord-006856-b1w25ob5 1749 10 range range NN cord-006856-b1w25ob5 1749 11 , , , cord-006856-b1w25ob5 1749 12 1 1 CD cord-006856-b1w25ob5 1749 13 - - SYM cord-006856-b1w25ob5 1749 14 28 28 CD cord-006856-b1w25ob5 1749 15 years year NNS cord-006856-b1w25ob5 1749 16 ; ; : cord-006856-b1w25ob5 1749 17 m m NNP cord-006856-b1w25ob5 1749 18 , , , cord-006856-b1w25ob5 1749 19 4 4 CD cord-006856-b1w25ob5 1749 20 ; ; : cord-006856-b1w25ob5 1749 21 f f NNP cord-006856-b1w25ob5 1749 22 , , , cord-006856-b1w25ob5 1749 23 4 4 CD cord-006856-b1w25ob5 1749 24 ) ) -RRB- cord-006856-b1w25ob5 1749 25 diagnosed diagnose VBN cord-006856-b1w25ob5 1749 26 with with IN cord-006856-b1w25ob5 1749 27 AML AML NNP cord-006856-b1w25ob5 1749 28 ( ( -LRB- cord-006856-b1w25ob5 1749 29 CR CR NNP cord-006856-b1w25ob5 1749 30 1 1 CD cord-006856-b1w25ob5 1749 31 , , , cord-006856-b1w25ob5 1749 32 n n NN cord-006856-b1w25ob5 1749 33 = = SYM cord-006856-b1w25ob5 1749 34 4 4 CD cord-006856-b1w25ob5 1749 35 ; ; : cord-006856-b1w25ob5 1749 36 CR CR NNP cord-006856-b1w25ob5 1749 37 2 2 CD cord-006856-b1w25ob5 1749 38 , , , cord-006856-b1w25ob5 1749 39 n n NN cord-006856-b1w25ob5 1749 40 = = SYM cord-006856-b1w25ob5 1749 41 1 1 CD cord-006856-b1w25ob5 1749 42 ) ) -RRB- cord-006856-b1w25ob5 1749 43 , , , cord-006856-b1w25ob5 1749 44 ALL all DT cord-006856-b1w25ob5 1749 45 ( ( -LRB- cord-006856-b1w25ob5 1749 46 CR CR NNP cord-006856-b1w25ob5 1749 47 3 3 CD cord-006856-b1w25ob5 1749 48 , , , cord-006856-b1w25ob5 1749 49 n n NN cord-006856-b1w25ob5 1749 50 = = SYM cord-006856-b1w25ob5 1749 51 1 1 CD cord-006856-b1w25ob5 1749 52 ) ) -RRB- cord-006856-b1w25ob5 1749 53 , , , cord-006856-b1w25ob5 1749 54 ALPS ALPS NNP cord-006856-b1w25ob5 1749 55 ( ( -LRB- cord-006856-b1w25ob5 1749 56 n n NN cord-006856-b1w25ob5 1749 57 = = SYM cord-006856-b1w25ob5 1749 58 1 1 CD cord-006856-b1w25ob5 1749 59 ) ) -RRB- cord-006856-b1w25ob5 1749 60 , , , cord-006856-b1w25ob5 1749 61 and and CC cord-006856-b1w25ob5 1749 62 relapsed relapse VBD cord-006856-b1w25ob5 1749 63 Ewing Ewing NNP cord-006856-b1w25ob5 1749 64 's 's POS cord-006856-b1w25ob5 1749 65 sarcoma sarcoma NN cord-006856-b1w25ob5 1749 66 ( ( -LRB- cord-006856-b1w25ob5 1749 67 n n NN cord-006856-b1w25ob5 1749 68 = = SYM cord-006856-b1w25ob5 1749 69 1 1 CD cord-006856-b1w25ob5 1749 70 ) ) -RRB- cord-006856-b1w25ob5 1749 71 . . . cord-006856-b1w25ob5 1750 1 7 7 CD cord-006856-b1w25ob5 1750 2 of of IN cord-006856-b1w25ob5 1750 3 8 8 CD cord-006856-b1w25ob5 1750 4 patients patient NNS cord-006856-b1w25ob5 1750 5 were be VBD cord-006856-b1w25ob5 1750 6 planned plan VBN cord-006856-b1w25ob5 1750 7 to to TO cord-006856-b1w25ob5 1750 8 receive receive VB cord-006856-b1w25ob5 1750 9 RIC RIC NNP cord-006856-b1w25ob5 1750 10 , , , cord-006856-b1w25ob5 1750 11 in in IN cord-006856-b1w25ob5 1750 12 one one CD cord-006856-b1w25ob5 1750 13 patient patient NN cord-006856-b1w25ob5 1750 14 the the DT cord-006856-b1w25ob5 1750 15 regime regime NN cord-006856-b1w25ob5 1750 16 was be VBD cord-006856-b1w25ob5 1750 17 changed change VBN cord-006856-b1w25ob5 1750 18 during during IN cord-006856-b1w25ob5 1750 19 conditioning conditioning NN cord-006856-b1w25ob5 1750 20 due due IN cord-006856-b1w25ob5 1750 21 to to IN cord-006856-b1w25ob5 1750 22 an an DT cord-006856-b1w25ob5 1750 23 acute acute JJ cord-006856-b1w25ob5 1750 24 viral viral JJ cord-006856-b1w25ob5 1750 25 infection infection NN cord-006856-b1w25ob5 1750 26 . . . cord-006856-b1w25ob5 1751 1 All all DT cord-006856-b1w25ob5 1751 2 patients patient NNS cord-006856-b1w25ob5 1751 3 received receive VBD cord-006856-b1w25ob5 1751 4 fludarabine fludarabine NN cord-006856-b1w25ob5 1751 5 ( ( -LRB- cord-006856-b1w25ob5 1751 6 n n NN cord-006856-b1w25ob5 1751 7 = = SYM cord-006856-b1w25ob5 1751 8 7 7 CD cord-006856-b1w25ob5 1751 9 , , , cord-006856-b1w25ob5 1751 10 150 150 CD cord-006856-b1w25ob5 1751 11 mg mg NNP cord-006856-b1w25ob5 1751 12 / / SYM cord-006856-b1w25ob5 1751 13 m m NNP cord-006856-b1w25ob5 1751 14 2 2 CD cord-006856-b1w25ob5 1751 15 ; ; : cord-006856-b1w25ob5 1751 16 n n NN cord-006856-b1w25ob5 1751 17 = = SYM cord-006856-b1w25ob5 1751 18 1 1 CD cord-006856-b1w25ob5 1751 19 , , , cord-006856-b1w25ob5 1751 20 60 60 CD cord-006856-b1w25ob5 1751 21 mg mg NNP cord-006856-b1w25ob5 1751 22 / / SYM cord-006856-b1w25ob5 1751 23 m m NN cord-006856-b1w25ob5 1751 24 2 2 CD cord-006856-b1w25ob5 1751 25 ) ) -RRB- cord-006856-b1w25ob5 1751 26 combined combine VBN cord-006856-b1w25ob5 1751 27 with with IN cord-006856-b1w25ob5 1751 28 melphalan melphalan NNP cord-006856-b1w25ob5 1751 29 ( ( -LRB- cord-006856-b1w25ob5 1751 30 n n NN cord-006856-b1w25ob5 1751 31 = = SYM cord-006856-b1w25ob5 1751 32 6 6 CD cord-006856-b1w25ob5 1751 33 , , , cord-006856-b1w25ob5 1751 34 100 100 CD cord-006856-b1w25ob5 1751 35 - - SYM cord-006856-b1w25ob5 1751 36 140 140 CD cord-006856-b1w25ob5 1751 37 mg mg NNP cord-006856-b1w25ob5 1751 38 / / SYM cord-006856-b1w25ob5 1751 39 m m NNP cord-006856-b1w25ob5 1751 40 2 2 CD cord-006856-b1w25ob5 1751 41 ) ) -RRB- cord-006856-b1w25ob5 1751 42 , , , cord-006856-b1w25ob5 1751 43 busulfan busulfan NNP cord-006856-b1w25ob5 1751 44 ( ( -LRB- cord-006856-b1w25ob5 1751 45 n n NN cord-006856-b1w25ob5 1751 46 = = SYM cord-006856-b1w25ob5 1751 47 1 1 CD cord-006856-b1w25ob5 1751 48 , , , cord-006856-b1w25ob5 1751 49 13 13 CD cord-006856-b1w25ob5 1751 50 mg mg NNP cord-006856-b1w25ob5 1751 51 / / SYM cord-006856-b1w25ob5 1751 52 kg kg NNP cord-006856-b1w25ob5 1751 53 ) ) -RRB- cord-006856-b1w25ob5 1751 54 , , , cord-006856-b1w25ob5 1751 55 or or CC cord-006856-b1w25ob5 1751 56 total total JJ cord-006856-b1w25ob5 1751 57 - - HYPH cord-006856-b1w25ob5 1751 58 body body NN cord-006856-b1w25ob5 1751 59 irradiation irradiation NN cord-006856-b1w25ob5 1751 60 ( ( -LRB- cord-006856-b1w25ob5 1751 61 n n NN cord-006856-b1w25ob5 1751 62 = = SYM cord-006856-b1w25ob5 1751 63 1 1 CD cord-006856-b1w25ob5 1751 64 , , , cord-006856-b1w25ob5 1751 65 2 2 CD cord-006856-b1w25ob5 1751 66 Gy Gy NNP cord-006856-b1w25ob5 1751 67 ) ) -RRB- cord-006856-b1w25ob5 1751 68 . . . cord-006856-b1w25ob5 1752 1 3 3 CD cord-006856-b1w25ob5 1752 2 patients patient NNS cord-006856-b1w25ob5 1752 3 received receive VBD cord-006856-b1w25ob5 1752 4 ATG ATG NNP cord-006856-b1w25ob5 1752 5 ( ( -LRB- cord-006856-b1w25ob5 1752 6 45 45 CD cord-006856-b1w25ob5 1752 7 - - SYM cord-006856-b1w25ob5 1752 8 60 60 CD cord-006856-b1w25ob5 1752 9 mg mg NNP cord-006856-b1w25ob5 1752 10 / / SYM cord-006856-b1w25ob5 1752 11 kg kg NNP cord-006856-b1w25ob5 1752 12 ) ) -RRB- cord-006856-b1w25ob5 1752 13 , , , cord-006856-b1w25ob5 1752 14 two two CD cord-006856-b1w25ob5 1752 15 patients patient NNS cord-006856-b1w25ob5 1752 16 campath campath NNP cord-006856-b1w25ob5 1752 17 ( ( -LRB- cord-006856-b1w25ob5 1752 18 40 40 CD cord-006856-b1w25ob5 1752 19 mg mg NNP cord-006856-b1w25ob5 1752 20 / / SYM cord-006856-b1w25ob5 1752 21 m m NNP cord-006856-b1w25ob5 1752 22 2 2 CD cord-006856-b1w25ob5 1752 23 ) ) -RRB- cord-006856-b1w25ob5 1752 24 . . . cord-006856-b1w25ob5 1753 1 Post post JJ cord-006856-b1w25ob5 1753 2 - - JJ cord-006856-b1w25ob5 1753 3 transplant transplant JJ cord-006856-b1w25ob5 1753 4 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1753 5 consisted consist VBD cord-006856-b1w25ob5 1753 6 of of IN cord-006856-b1w25ob5 1753 7 cyclosporine cyclosporine NN cord-006856-b1w25ob5 1753 8 A a NN cord-006856-b1w25ob5 1753 9 in in IN cord-006856-b1w25ob5 1753 10 all all DT cord-006856-b1w25ob5 1753 11 patients patient NNS cord-006856-b1w25ob5 1753 12 combined combine VBN cord-006856-b1w25ob5 1753 13 with with IN cord-006856-b1w25ob5 1753 14 mycophenolate mycophenolate NNP cord-006856-b1w25ob5 1753 15 mofetil mofetil NNP cord-006856-b1w25ob5 1753 16 ( ( -LRB- cord-006856-b1w25ob5 1753 17 n n NN cord-006856-b1w25ob5 1753 18 = = SYM cord-006856-b1w25ob5 1753 19 1 1 CD cord-006856-b1w25ob5 1753 20 ) ) -RRB- cord-006856-b1w25ob5 1753 21 or or CC cord-006856-b1w25ob5 1753 22 methotrexate methotrexate NNP cord-006856-b1w25ob5 1753 23 ( ( -LRB- cord-006856-b1w25ob5 1753 24 n n NN cord-006856-b1w25ob5 1753 25 = = SYM cord-006856-b1w25ob5 1753 26 2 2 CD cord-006856-b1w25ob5 1753 27 ) ) -RRB- cord-006856-b1w25ob5 1753 28 . . . cord-006856-b1w25ob5 1754 1 7 7 CD cord-006856-b1w25ob5 1754 2 of of IN cord-006856-b1w25ob5 1754 3 8 8 CD cord-006856-b1w25ob5 1754 4 patients patient NNS cord-006856-b1w25ob5 1754 5 received receive VBD cord-006856-b1w25ob5 1754 6 HLA HLA NNP cord-006856-b1w25ob5 1754 7 identical identical JJ cord-006856-b1w25ob5 1754 8 grafts graft NNS cord-006856-b1w25ob5 1754 9 ( ( -LRB- cord-006856-b1w25ob5 1754 10 sibling sibling NN cord-006856-b1w25ob5 1754 11 , , , cord-006856-b1w25ob5 1754 12 n n NN cord-006856-b1w25ob5 1754 13 = = SYM cord-006856-b1w25ob5 1754 14 3 3 CD cord-006856-b1w25ob5 1754 15 ; ; . cord-006856-b1w25ob5 1755 1 HLA HLA NNP cord-006856-b1w25ob5 1755 2 identical identical JJ cord-006856-b1w25ob5 1755 3 mother mother NN cord-006856-b1w25ob5 1755 4 , , , cord-006856-b1w25ob5 1755 5 n n NN cord-006856-b1w25ob5 1755 6 = = SYM cord-006856-b1w25ob5 1755 7 2 2 CD cord-006856-b1w25ob5 1755 8 ; ; , cord-006856-b1w25ob5 1755 9 MUD mud NN cord-006856-b1w25ob5 1755 10 , , , cord-006856-b1w25ob5 1755 11 n n NN cord-006856-b1w25ob5 1755 12 = = SYM cord-006856-b1w25ob5 1755 13 2 2 CD cord-006856-b1w25ob5 1755 14 ) ) -RRB- cord-006856-b1w25ob5 1755 15 , , , cord-006856-b1w25ob5 1755 16 one one CD cord-006856-b1w25ob5 1755 17 patient patient NN cord-006856-b1w25ob5 1755 18 received receive VBD cord-006856-b1w25ob5 1755 19 a a DT cord-006856-b1w25ob5 1755 20 c c NN cord-006856-b1w25ob5 1755 21 - - HYPH cord-006856-b1w25ob5 1755 22 locus locus NN cord-006856-b1w25ob5 1755 23 mismatched mismatch VBN cord-006856-b1w25ob5 1755 24 graft graft NN cord-006856-b1w25ob5 1755 25 . . . cord-006856-b1w25ob5 1756 1 Stem stem JJ cord-006856-b1w25ob5 1756 2 cell cell NN cord-006856-b1w25ob5 1756 3 sources source NNS cord-006856-b1w25ob5 1756 4 were be VBD cord-006856-b1w25ob5 1756 5 bone bone NN cord-006856-b1w25ob5 1756 6 marrow marrow NN cord-006856-b1w25ob5 1756 7 in in IN cord-006856-b1w25ob5 1756 8 6 6 CD cord-006856-b1w25ob5 1756 9 patients patient NNS cord-006856-b1w25ob5 1756 10 and and CC cord-006856-b1w25ob5 1756 11 peripheral peripheral JJ cord-006856-b1w25ob5 1756 12 blood blood NN cord-006856-b1w25ob5 1756 13 stem stem NN cord-006856-b1w25ob5 1756 14 cells cell NNS cord-006856-b1w25ob5 1756 15 in in IN cord-006856-b1w25ob5 1756 16 2 2 CD cord-006856-b1w25ob5 1756 17 containing contain VBG cord-006856-b1w25ob5 1756 18 a a DT cord-006856-b1w25ob5 1756 19 median median NN cord-006856-b1w25ob5 1756 20 of of IN cord-006856-b1w25ob5 1756 21 5.13 5.13 CD cord-006856-b1w25ob5 1756 22 × × NN cord-006856-b1w25ob5 1756 23 10 10 CD cord-006856-b1w25ob5 1756 24 6 6 CD cord-006856-b1w25ob5 1756 25 CD34 CD34 NNP cord-006856-b1w25ob5 1756 26 + + CC cord-006856-b1w25ob5 1756 27 cells cell NNS cord-006856-b1w25ob5 1756 28 per per IN cord-006856-b1w25ob5 1756 29 kg kg NNS cord-006856-b1w25ob5 1756 30 of of IN cord-006856-b1w25ob5 1756 31 body body NN cord-006856-b1w25ob5 1756 32 weight weight NN cord-006856-b1w25ob5 1756 33 of of IN cord-006856-b1w25ob5 1756 34 the the DT cord-006856-b1w25ob5 1756 35 recipient recipient NN cord-006856-b1w25ob5 1756 36 . . . cord-006856-b1w25ob5 1757 1 Results result NNS cord-006856-b1w25ob5 1757 2 . . . cord-006856-b1w25ob5 1758 1 All all DT cord-006856-b1w25ob5 1758 2 patients patient NNS cord-006856-b1w25ob5 1758 3 had have VBD cord-006856-b1w25ob5 1758 4 primary primary JJ cord-006856-b1w25ob5 1758 5 engraftment engraftment NN cord-006856-b1w25ob5 1758 6 ; ; : cord-006856-b1w25ob5 1758 7 the the DT cord-006856-b1w25ob5 1758 8 median median JJ cord-006856-b1w25ob5 1758 9 time time NN cord-006856-b1w25ob5 1758 10 to to IN cord-006856-b1w25ob5 1758 11 neutrophil neutrophil NN cord-006856-b1w25ob5 1758 12 recovery recovery NN cord-006856-b1w25ob5 1759 1 ( ( -LRB- cord-006856-b1w25ob5 1759 2 N N NNP cord-006856-b1w25ob5 1759 3 > > XX cord-006856-b1w25ob5 1759 4 1.0 1.0 CD cord-006856-b1w25ob5 1759 5 × × NN cord-006856-b1w25ob5 1759 6 10 10 CD cord-006856-b1w25ob5 1759 7 9 9 CD cord-006856-b1w25ob5 1759 8 /l /l NN cord-006856-b1w25ob5 1759 9 ) ) -RRB- cord-006856-b1w25ob5 1759 10 was be VBD cord-006856-b1w25ob5 1759 11 15 15 CD cord-006856-b1w25ob5 1759 12 days day NNS cord-006856-b1w25ob5 1759 13 . . . cord-006856-b1w25ob5 1760 1 Complete complete JJ cord-006856-b1w25ob5 1760 2 donor donor NN cord-006856-b1w25ob5 1760 3 chimerism chimerism NN cord-006856-b1w25ob5 1760 4 as as IN cord-006856-b1w25ob5 1760 5 evidenced evidence VBN cord-006856-b1w25ob5 1760 6 by by IN cord-006856-b1w25ob5 1760 7 VNTR VNTR NNP cord-006856-b1w25ob5 1760 8 was be VBD cord-006856-b1w25ob5 1760 9 achieved achieve VBN cord-006856-b1w25ob5 1760 10 in in IN cord-006856-b1w25ob5 1760 11 median median NN cord-006856-b1w25ob5 1760 12 on on IN cord-006856-b1w25ob5 1760 13 day day NN cord-006856-b1w25ob5 1760 14 +22 +22 NNS cord-006856-b1w25ob5 1761 1 ( ( -LRB- cord-006856-b1w25ob5 1761 2 +11 +11 NNS cord-006856-b1w25ob5 1761 3 to to IN cord-006856-b1w25ob5 1761 4 +28 +28 CD cord-006856-b1w25ob5 1761 5 ) ) -RRB- cord-006856-b1w25ob5 1761 6 . . . cord-006856-b1w25ob5 1762 1 Acute acute JJ cord-006856-b1w25ob5 1762 2 mild mild JJ cord-006856-b1w25ob5 1762 3 graftversus graftversus NN cord-006856-b1w25ob5 1762 4 - - HYPH cord-006856-b1w25ob5 1762 5 host host NN cord-006856-b1w25ob5 1762 6 disease disease NN cord-006856-b1w25ob5 1762 7 ( ( -LRB- cord-006856-b1w25ob5 1762 8 GVHD GVHD NNP cord-006856-b1w25ob5 1762 9 ) ) -RRB- cord-006856-b1w25ob5 1762 10 of of IN cord-006856-b1w25ob5 1762 11 the the DT cord-006856-b1w25ob5 1762 12 skin skin NN cord-006856-b1w25ob5 1762 13 occurred occur VBD cord-006856-b1w25ob5 1762 14 in in IN cord-006856-b1w25ob5 1762 15 5 5 CD cord-006856-b1w25ob5 1762 16 of of IN cord-006856-b1w25ob5 1762 17 8 8 CD cord-006856-b1w25ob5 1762 18 patients patient NNS cord-006856-b1w25ob5 1762 19 and and CC cord-006856-b1w25ob5 1762 20 responded respond VBD cord-006856-b1w25ob5 1762 21 to to IN cord-006856-b1w25ob5 1762 22 prednisolone prednisolone NN cord-006856-b1w25ob5 1762 23 ; ; : cord-006856-b1w25ob5 1762 24 one one CD cord-006856-b1w25ob5 1762 25 patient patient NN cord-006856-b1w25ob5 1762 26 required require VBD cord-006856-b1w25ob5 1762 27 additional additional JJ cord-006856-b1w25ob5 1762 28 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1762 29 with with IN cord-006856-b1w25ob5 1762 30 MMF MMF NNP cord-006856-b1w25ob5 1762 31 . . . cord-006856-b1w25ob5 1763 1 One one CD cord-006856-b1w25ob5 1763 2 patient patient NN cord-006856-b1w25ob5 1763 3 progressed progress VBD cord-006856-b1w25ob5 1763 4 to to TO cord-006856-b1w25ob5 1763 5 extensive extensive JJ cord-006856-b1w25ob5 1763 6 chronic chronic JJ cord-006856-b1w25ob5 1763 7 GVHD gvhd NN cord-006856-b1w25ob5 1763 8 ; ; : cord-006856-b1w25ob5 1763 9 one one CD cord-006856-b1w25ob5 1763 10 patient patient NN cord-006856-b1w25ob5 1763 11 developed develop VBD cord-006856-b1w25ob5 1763 12 chronic chronic JJ cord-006856-b1w25ob5 1763 13 GVHD GVHD NNP cord-006856-b1w25ob5 1763 14 of of IN cord-006856-b1w25ob5 1763 15 the the DT cord-006856-b1w25ob5 1763 16 skin skin NN cord-006856-b1w25ob5 1763 17 , , , cord-006856-b1w25ob5 1763 18 another another DT cord-006856-b1w25ob5 1763 19 patient patient NN cord-006856-b1w25ob5 1763 20 shows show VBZ cord-006856-b1w25ob5 1763 21 clinical clinical JJ cord-006856-b1w25ob5 1763 22 evidence evidence NN cord-006856-b1w25ob5 1763 23 of of IN cord-006856-b1w25ob5 1763 24 chronic chronic JJ cord-006856-b1w25ob5 1763 25 GVHD GVHD NNP cord-006856-b1w25ob5 1763 26 of of IN cord-006856-b1w25ob5 1763 27 liver liver NN cord-006856-b1w25ob5 1763 28 and and CC cord-006856-b1w25ob5 1763 29 gut gut NN cord-006856-b1w25ob5 1763 30 . . . cord-006856-b1w25ob5 1764 1 The the DT cord-006856-b1w25ob5 1764 2 remaining remain VBG cord-006856-b1w25ob5 1764 3 3 3 CD cord-006856-b1w25ob5 1764 4 patients patient NNS cord-006856-b1w25ob5 1764 5 showed show VBD cord-006856-b1w25ob5 1764 6 no no DT cord-006856-b1w25ob5 1764 7 GVHD gvhd NN cord-006856-b1w25ob5 1764 8 at at RB cord-006856-b1w25ob5 1764 9 all all RB cord-006856-b1w25ob5 1764 10 . . . cord-006856-b1w25ob5 1765 1 5 5 CD cord-006856-b1w25ob5 1765 2 of of IN cord-006856-b1w25ob5 1765 3 8 8 CD cord-006856-b1w25ob5 1765 4 patients patient NNS cord-006856-b1w25ob5 1765 5 were be VBD cord-006856-b1w25ob5 1765 6 positive positive JJ cord-006856-b1w25ob5 1765 7 for for IN cord-006856-b1w25ob5 1765 8 one one CD cord-006856-b1w25ob5 1765 9 or or CC cord-006856-b1w25ob5 1765 10 multiple multiple JJ cord-006856-b1w25ob5 1765 11 viruses virus NNS cord-006856-b1w25ob5 1765 12 on on IN cord-006856-b1w25ob5 1765 13 routine routine JJ cord-006856-b1w25ob5 1765 14 viral viral JJ cord-006856-b1w25ob5 1765 15 PCR pcr NN cord-006856-b1w25ob5 1765 16 monitoring monitoring NN cord-006856-b1w25ob5 1765 17 , , , cord-006856-b1w25ob5 1765 18 requiring require VBG cord-006856-b1w25ob5 1765 19 virostatic virostatic JJ cord-006856-b1w25ob5 1765 20 treatment treatment NN cord-006856-b1w25ob5 1765 21 . . . cord-006856-b1w25ob5 1766 1 No no DT cord-006856-b1w25ob5 1766 2 treatment treatment NN cord-006856-b1w25ob5 1766 3 - - HYPH cord-006856-b1w25ob5 1766 4 related relate VBN cord-006856-b1w25ob5 1766 5 mortality mortality NN cord-006856-b1w25ob5 1766 6 occurred occur VBD cord-006856-b1w25ob5 1766 7 . . . cord-006856-b1w25ob5 1767 1 The the DT cord-006856-b1w25ob5 1767 2 patient patient NN cord-006856-b1w25ob5 1767 3 with with IN cord-006856-b1w25ob5 1767 4 Ewing Ewing NNP cord-006856-b1w25ob5 1767 5 's 's POS cord-006856-b1w25ob5 1767 6 sarcoma sarcoma NN cord-006856-b1w25ob5 1767 7 died die VBD cord-006856-b1w25ob5 1767 8 4 4 CD cord-006856-b1w25ob5 1767 9 months month NNS cord-006856-b1w25ob5 1767 10 posttransplant posttransplant JJ cord-006856-b1w25ob5 1767 11 from from IN cord-006856-b1w25ob5 1767 12 tumor tumor NN cord-006856-b1w25ob5 1767 13 progression progression NN cord-006856-b1w25ob5 1767 14 ; ; : cord-006856-b1w25ob5 1767 15 the the DT cord-006856-b1w25ob5 1767 16 patient patient NN cord-006856-b1w25ob5 1767 17 with with IN cord-006856-b1w25ob5 1767 18 extensive extensive JJ cord-006856-b1w25ob5 1767 19 chronic chronic JJ cord-006856-b1w25ob5 1767 20 GVHD GVHD NNP cord-006856-b1w25ob5 1767 21 died die VBD cord-006856-b1w25ob5 1767 22 of of IN cord-006856-b1w25ob5 1767 23 sepsis sepsis NN cord-006856-b1w25ob5 1767 24 on on IN cord-006856-b1w25ob5 1767 25 day day NN cord-006856-b1w25ob5 1767 26 +400 +400 NNP cord-006856-b1w25ob5 1767 27 . . . cord-006856-b1w25ob5 1768 1 All all DT cord-006856-b1w25ob5 1768 2 5 5 CD cord-006856-b1w25ob5 1768 3 patients patient NNS cord-006856-b1w25ob5 1768 4 with with IN cord-006856-b1w25ob5 1768 5 AML AML NNP cord-006856-b1w25ob5 1768 6 are be VBP cord-006856-b1w25ob5 1768 7 in in IN cord-006856-b1w25ob5 1768 8 remission remission NN cord-006856-b1w25ob5 1768 9 . . . cord-006856-b1w25ob5 1769 1 The the DT cord-006856-b1w25ob5 1769 2 patient patient NN cord-006856-b1w25ob5 1769 3 with with IN cord-006856-b1w25ob5 1769 4 ALPS ALPS NNP cord-006856-b1w25ob5 1769 5 is be VBZ cord-006856-b1w25ob5 1769 6 still still RB cord-006856-b1w25ob5 1769 7 positive positive JJ cord-006856-b1w25ob5 1769 8 for for IN cord-006856-b1w25ob5 1769 9 various various JJ cord-006856-b1w25ob5 1769 10 autoantibodies autoantibody NNS cord-006856-b1w25ob5 1769 11 . . . cord-006856-b1w25ob5 1770 1 3 3 CD cord-006856-b1w25ob5 1770 2 patients patient NNS cord-006856-b1w25ob5 1770 3 developed develop VBD cord-006856-b1w25ob5 1770 4 a a DT cord-006856-b1w25ob5 1770 5 posttransplant posttransplant NN cord-006856-b1w25ob5 1770 6 macrophage macrophage NN cord-006856-b1w25ob5 1770 7 - - HYPH cord-006856-b1w25ob5 1770 8 activation activation NN cord-006856-b1w25ob5 1770 9 syndrome syndrome NN cord-006856-b1w25ob5 1770 10 ( ( -LRB- cord-006856-b1w25ob5 1770 11 MAS MAS NNP cord-006856-b1w25ob5 1770 12 ) ) -RRB- cord-006856-b1w25ob5 1770 13 . . . cord-006856-b1w25ob5 1771 1 All all DT cord-006856-b1w25ob5 1771 2 of of IN cord-006856-b1w25ob5 1771 3 them -PRON- PRP cord-006856-b1w25ob5 1771 4 required require VBD cord-006856-b1w25ob5 1771 5 a a DT cord-006856-b1w25ob5 1771 6 stem stem NN cord-006856-b1w25ob5 1771 7 cell cell NN cord-006856-b1w25ob5 1771 8 boost boost NN cord-006856-b1w25ob5 1771 9 because because IN cord-006856-b1w25ob5 1771 10 of of IN cord-006856-b1w25ob5 1771 11 pancytopenia pancytopenia NNP cord-006856-b1w25ob5 1771 12 . . . cord-006856-b1w25ob5 1772 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1772 2 . . . cord-006856-b1w25ob5 1773 1 RIC RIC NNP cord-006856-b1w25ob5 1773 2 followed follow VBD cord-006856-b1w25ob5 1773 3 by by IN cord-006856-b1w25ob5 1773 4 allogeneic allogeneic NN cord-006856-b1w25ob5 1773 5 HSCT HSCT NNP cord-006856-b1w25ob5 1773 6 was be VBD cord-006856-b1w25ob5 1773 7 successful successful JJ cord-006856-b1w25ob5 1773 8 in in IN cord-006856-b1w25ob5 1773 9 terms term NNS cord-006856-b1w25ob5 1773 10 of of IN cord-006856-b1w25ob5 1773 11 achieving achieve VBG cord-006856-b1w25ob5 1773 12 primary primary JJ cord-006856-b1w25ob5 1773 13 engraftment engraftment NN cord-006856-b1w25ob5 1773 14 and and CC cord-006856-b1w25ob5 1773 15 complete complete JJ cord-006856-b1w25ob5 1773 16 donor donor NN cord-006856-b1w25ob5 1773 17 chimerism chimerism NN cord-006856-b1w25ob5 1773 18 as as RB cord-006856-b1w25ob5 1773 19 well well RB cord-006856-b1w25ob5 1773 20 as as IN cord-006856-b1w25ob5 1773 21 avoiding avoid VBG cord-006856-b1w25ob5 1773 22 transplant transplant NN cord-006856-b1w25ob5 1773 23 - - HYPH cord-006856-b1w25ob5 1773 24 related relate VBN cord-006856-b1w25ob5 1773 25 mortality mortality NN cord-006856-b1w25ob5 1773 26 in in IN cord-006856-b1w25ob5 1773 27 all all DT cord-006856-b1w25ob5 1773 28 patients patient NNS cord-006856-b1w25ob5 1773 29 ; ; : cord-006856-b1w25ob5 1773 30 in in IN cord-006856-b1w25ob5 1773 31 our -PRON- PRP$ cord-006856-b1w25ob5 1773 32 patients patient NNS cord-006856-b1w25ob5 1773 33 with with IN cord-006856-b1w25ob5 1773 34 myeloid myeloid JJ cord-006856-b1w25ob5 1773 35 malignancies malignancy NNS cord-006856-b1w25ob5 1773 36 it -PRON- PRP cord-006856-b1w25ob5 1773 37 was be VBD cord-006856-b1w25ob5 1773 38 also also RB cord-006856-b1w25ob5 1773 39 successful successful JJ cord-006856-b1w25ob5 1773 40 in in IN cord-006856-b1w25ob5 1773 41 terms term NNS cord-006856-b1w25ob5 1773 42 of of IN cord-006856-b1w25ob5 1773 43 maintaining maintain VBG cord-006856-b1w25ob5 1773 44 stable stable JJ cord-006856-b1w25ob5 1773 45 remission remission NN cord-006856-b1w25ob5 1773 46 . . . cord-006856-b1w25ob5 1774 1 As as IN cord-006856-b1w25ob5 1774 2 for for IN cord-006856-b1w25ob5 1774 3 posttransplant posttransplant NN cord-006856-b1w25ob5 1774 4 problems problem NNS cord-006856-b1w25ob5 1774 5 , , , cord-006856-b1w25ob5 1774 6 we -PRON- PRP cord-006856-b1w25ob5 1774 7 encountered encounter VBD cord-006856-b1w25ob5 1774 8 acute acute JJ cord-006856-b1w25ob5 1774 9 GVHD GVHD NNP cord-006856-b1w25ob5 1774 10 of of IN cord-006856-b1w25ob5 1774 11 the the DT cord-006856-b1w25ob5 1774 12 skin skin NN cord-006856-b1w25ob5 1774 13 in in IN cord-006856-b1w25ob5 1774 14 5 5 CD cord-006856-b1w25ob5 1774 15 of of IN cord-006856-b1w25ob5 1774 16 8 8 CD cord-006856-b1w25ob5 1774 17 patients patient NNS cord-006856-b1w25ob5 1774 18 , , , cord-006856-b1w25ob5 1774 19 three three CD cord-006856-b1w25ob5 1774 20 of of IN cord-006856-b1w25ob5 1774 21 whom whom WP cord-006856-b1w25ob5 1774 22 developed develop VBD cord-006856-b1w25ob5 1774 23 chronic chronic JJ cord-006856-b1w25ob5 1774 24 GVHD GVHD NNP cord-006856-b1w25ob5 1774 25 ; ; : cord-006856-b1w25ob5 1774 26 and and CC cord-006856-b1w25ob5 1774 27 viral viral JJ cord-006856-b1w25ob5 1774 28 infections infection NNS cord-006856-b1w25ob5 1774 29 in in IN cord-006856-b1w25ob5 1774 30 5 5 CD cord-006856-b1w25ob5 1774 31 of of IN cord-006856-b1w25ob5 1774 32 8 8 CD cord-006856-b1w25ob5 1774 33 patients patient NNS cord-006856-b1w25ob5 1774 34 , , , cord-006856-b1w25ob5 1774 35 three three CD cord-006856-b1w25ob5 1774 36 of of IN cord-006856-b1w25ob5 1774 37 whom whom WP cord-006856-b1w25ob5 1774 38 developed develop VBD cord-006856-b1w25ob5 1774 39 MAS MAS NNP cord-006856-b1w25ob5 1774 40 and and CC cord-006856-b1w25ob5 1774 41 eventually eventually RB cord-006856-b1w25ob5 1774 42 required require VBD cord-006856-b1w25ob5 1774 43 a a DT cord-006856-b1w25ob5 1774 44 stem stem NN cord-006856-b1w25ob5 1774 45 cell cell NN cord-006856-b1w25ob5 1774 46 boost boost NN cord-006856-b1w25ob5 1774 47 . . . cord-006856-b1w25ob5 1774 48 _SP cord-006856-b1w25ob5 1775 1 Background background NN cord-006856-b1w25ob5 1775 2 . . . cord-006856-b1w25ob5 1776 1 Due due IN cord-006856-b1w25ob5 1776 2 to to IN cord-006856-b1w25ob5 1776 3 an an DT cord-006856-b1w25ob5 1776 4 aggressive aggressive JJ cord-006856-b1w25ob5 1776 5 course course NN cord-006856-b1w25ob5 1776 6 mantle mantle NN cord-006856-b1w25ob5 1776 7 cell cell NN cord-006856-b1w25ob5 1776 8 lymphoma lymphoma NN cord-006856-b1w25ob5 1776 9 is be VBZ cord-006856-b1w25ob5 1776 10 characterized characterize VBN cord-006856-b1w25ob5 1776 11 by by IN cord-006856-b1w25ob5 1776 12 poor poor JJ cord-006856-b1w25ob5 1776 13 prognosis prognosis NN cord-006856-b1w25ob5 1776 14 with with IN cord-006856-b1w25ob5 1776 15 a a DT cord-006856-b1w25ob5 1776 16 median median JJ cord-006856-b1w25ob5 1776 17 survival survival NN cord-006856-b1w25ob5 1776 18 of of IN cord-006856-b1w25ob5 1776 19 3 3 CD cord-006856-b1w25ob5 1776 20 years year NNS cord-006856-b1w25ob5 1776 21 and and CC cord-006856-b1w25ob5 1776 22 only only RB cord-006856-b1w25ob5 1776 23 10 10 CD cord-006856-b1w25ob5 1776 24 - - SYM cord-006856-b1w25ob5 1776 25 15 15 CD cord-006856-b1w25ob5 1776 26 % % NN cord-006856-b1w25ob5 1776 27 long long JJ cord-006856-b1w25ob5 1776 28 - - HYPH cord-006856-b1w25ob5 1776 29 time time NN cord-006856-b1w25ob5 1776 30 survivors survivor NNS cord-006856-b1w25ob5 1776 31 . . . cord-006856-b1w25ob5 1777 1 Recent recent JJ cord-006856-b1w25ob5 1777 2 improvements improvement NNS cord-006856-b1w25ob5 1777 3 in in IN cord-006856-b1w25ob5 1777 4 therapy therapy NN cord-006856-b1w25ob5 1777 5 have have VBP cord-006856-b1w25ob5 1777 6 been be VBN cord-006856-b1w25ob5 1777 7 made make VBN cord-006856-b1w25ob5 1777 8 by by IN cord-006856-b1w25ob5 1777 9 combined combine VBN cord-006856-b1w25ob5 1777 10 immunochemotherapy immunochemotherapy NN cord-006856-b1w25ob5 1777 11 and and CC cord-006856-b1w25ob5 1777 12 intensification intensification NN cord-006856-b1w25ob5 1777 13 with with IN cord-006856-b1w25ob5 1777 14 high high JJ cord-006856-b1w25ob5 1777 15 - - HYPH cord-006856-b1w25ob5 1777 16 dose dose NN cord-006856-b1w25ob5 1777 17 chemotherapy chemotherapy NN cord-006856-b1w25ob5 1777 18 . . . cord-006856-b1w25ob5 1778 1 Methods method NNS cord-006856-b1w25ob5 1778 2 und und IN cord-006856-b1w25ob5 1778 3 results result NNS cord-006856-b1w25ob5 1778 4 . . . cord-006856-b1w25ob5 1779 1 Ten ten CD cord-006856-b1w25ob5 1779 2 patients patient NNS cord-006856-b1w25ob5 1779 3 ( ( -LRB- cord-006856-b1w25ob5 1779 4 4 4 CD cord-006856-b1w25ob5 1779 5 female female JJ cord-006856-b1w25ob5 1779 6 , , , cord-006856-b1w25ob5 1779 7 6 6 CD cord-006856-b1w25ob5 1779 8 male male NN cord-006856-b1w25ob5 1779 9 ) ) -RRB- cord-006856-b1w25ob5 1779 10 with with IN cord-006856-b1w25ob5 1779 11 a a DT cord-006856-b1w25ob5 1779 12 median median JJ cord-006856-b1w25ob5 1779 13 age age NN cord-006856-b1w25ob5 1779 14 of of IN cord-006856-b1w25ob5 1779 15 56 56 CD cord-006856-b1w25ob5 1779 16 ( ( -LRB- cord-006856-b1w25ob5 1779 17 49 49 CD cord-006856-b1w25ob5 1779 18 - - SYM cord-006856-b1w25ob5 1779 19 65 65 CD cord-006856-b1w25ob5 1779 20 ) ) -RRB- cord-006856-b1w25ob5 1779 21 years year NNS cord-006856-b1w25ob5 1779 22 were be VBD cord-006856-b1w25ob5 1779 23 treated treat VBN cord-006856-b1w25ob5 1779 24 with with IN cord-006856-b1w25ob5 1779 25 Rituximab Rituximab NNP cord-006856-b1w25ob5 1779 26 plus plus CC cord-006856-b1w25ob5 1779 27 CHOP chop VB cord-006856-b1w25ob5 1779 28 for for IN cord-006856-b1w25ob5 1779 29 four four CD cord-006856-b1w25ob5 1779 30 or or CC cord-006856-b1w25ob5 1779 31 six six CD cord-006856-b1w25ob5 1779 32 cycles cycle NNS cord-006856-b1w25ob5 1779 33 . . . cord-006856-b1w25ob5 1780 1 Furtheron Furtheron NNP cord-006856-b1w25ob5 1780 2 , , , cord-006856-b1w25ob5 1780 3 patients patient NNS cord-006856-b1w25ob5 1780 4 received receive VBD cord-006856-b1w25ob5 1780 5 2 2 CD cord-006856-b1w25ob5 1780 6 or or CC cord-006856-b1w25ob5 1780 7 3 3 CD cord-006856-b1w25ob5 1780 8 cycles cycle NNS cord-006856-b1w25ob5 1780 9 of of IN cord-006856-b1w25ob5 1780 10 CLAEG CLAEG NNP cord-006856-b1w25ob5 1780 11 - - HYPH cord-006856-b1w25ob5 1780 12 D D NNP cord-006856-b1w25ob5 1781 1 ( ( -LRB- cord-006856-b1w25ob5 1781 2 3 3 CD cord-006856-b1w25ob5 1781 3 days day NNS cord-006856-b1w25ob5 1781 4 Cladribine Cladribine NNP cord-006856-b1w25ob5 1781 5 0.2 0.2 CD cord-006856-b1w25ob5 1781 6 mg mg NNP cord-006856-b1w25ob5 1781 7 / / SYM cord-006856-b1w25ob5 1781 8 kg kg NNP cord-006856-b1w25ob5 1781 9 , , , cord-006856-b1w25ob5 1781 10 ARA ARA NNP cord-006856-b1w25ob5 1781 11 - - HYPH cord-006856-b1w25ob5 1781 12 C C NNP cord-006856-b1w25ob5 1781 13 1.5 1.5 CD cord-006856-b1w25ob5 1781 14 g g NN cord-006856-b1w25ob5 1781 15 / / SYM cord-006856-b1w25ob5 1781 16 m m NN cord-006856-b1w25ob5 1781 17 2 2 CD cord-006856-b1w25ob5 1781 18 , , , cord-006856-b1w25ob5 1781 19 Etoposid Etoposid NNP cord-006856-b1w25ob5 1781 20 60 60 CD cord-006856-b1w25ob5 1781 21 mg mg NNP cord-006856-b1w25ob5 1781 22 / / SYM cord-006856-b1w25ob5 1781 23 m m NNP cord-006856-b1w25ob5 1781 24 2 2 CD cord-006856-b1w25ob5 1781 25 , , , cord-006856-b1w25ob5 1781 26 and and CC cord-006856-b1w25ob5 1781 27 on on IN cord-006856-b1w25ob5 1781 28 day day NN cord-006856-b1w25ob5 1781 29 1 1 CD cord-006856-b1w25ob5 1781 30 Daunoxome Daunoxome NNP cord-006856-b1w25ob5 1781 31 80 80 CD cord-006856-b1w25ob5 1781 32 mg mg NNP cord-006856-b1w25ob5 1781 33 / / SYM cord-006856-b1w25ob5 1781 34 m m NN cord-006856-b1w25ob5 1781 35 2 2 CD cord-006856-b1w25ob5 1781 36 ) ) -RRB- cord-006856-b1w25ob5 1781 37 including include VBG cord-006856-b1w25ob5 1781 38 stem stem NN cord-006856-b1w25ob5 1781 39 cell cell NN cord-006856-b1w25ob5 1781 40 collection collection NN cord-006856-b1w25ob5 1781 41 . . . cord-006856-b1w25ob5 1782 1 As as IN cord-006856-b1w25ob5 1782 2 a a DT cord-006856-b1w25ob5 1782 3 result result NN cord-006856-b1w25ob5 1782 4 , , , cord-006856-b1w25ob5 1782 5 5 5 CD cord-006856-b1w25ob5 1782 6 out out IN cord-006856-b1w25ob5 1782 7 of of IN cord-006856-b1w25ob5 1782 8 7 7 CD cord-006856-b1w25ob5 1782 9 newly newly RB cord-006856-b1w25ob5 1782 10 diagnosed diagnose VBN cord-006856-b1w25ob5 1782 11 patients patient NNS cord-006856-b1w25ob5 1782 12 reached reach VBD cord-006856-b1w25ob5 1782 13 CR1 CR1 NNP cord-006856-b1w25ob5 1782 14 and and CC cord-006856-b1w25ob5 1782 15 2 2 CD cord-006856-b1w25ob5 1782 16 PR pr NN cord-006856-b1w25ob5 1782 17 . . . cord-006856-b1w25ob5 1783 1 Out out IN cord-006856-b1w25ob5 1783 2 of of IN cord-006856-b1w25ob5 1783 3 3 3 CD cord-006856-b1w25ob5 1783 4 patients patient NNS cord-006856-b1w25ob5 1783 5 treated treat VBN cord-006856-b1w25ob5 1783 6 after after IN cord-006856-b1w25ob5 1783 7 first first JJ cord-006856-b1w25ob5 1783 8 relapse relapse NN cord-006856-b1w25ob5 1783 9 , , , cord-006856-b1w25ob5 1783 10 2 2 CD cord-006856-b1w25ob5 1783 11 reached reach VBD cord-006856-b1w25ob5 1783 12 again again RB cord-006856-b1w25ob5 1783 13 CR cr NN cord-006856-b1w25ob5 1783 14 and and CC cord-006856-b1w25ob5 1783 15 1 1 CD cord-006856-b1w25ob5 1783 16 PR pr NN cord-006856-b1w25ob5 1783 17 . . . cord-006856-b1w25ob5 1784 1 Autologous autologous JJ cord-006856-b1w25ob5 1784 2 transplantation transplantation NN cord-006856-b1w25ob5 1784 3 was be VBD cord-006856-b1w25ob5 1784 4 performed perform VBN cord-006856-b1w25ob5 1784 5 at at IN cord-006856-b1w25ob5 1784 6 a a DT cord-006856-b1w25ob5 1784 7 median median NN cord-006856-b1w25ob5 1784 8 of of IN cord-006856-b1w25ob5 1784 9 9 9 CD cord-006856-b1w25ob5 1784 10 ( ( -LRB- cord-006856-b1w25ob5 1784 11 5 5 CD cord-006856-b1w25ob5 1784 12 - - SYM cord-006856-b1w25ob5 1784 13 11 11 CD cord-006856-b1w25ob5 1784 14 ) ) -RRB- cord-006856-b1w25ob5 1784 15 months month NNS cord-006856-b1w25ob5 1784 16 after after IN cord-006856-b1w25ob5 1784 17 diagnosis diagnosis NN cord-006856-b1w25ob5 1784 18 . . . cord-006856-b1w25ob5 1785 1 High high JJ cord-006856-b1w25ob5 1785 2 - - HYPH cord-006856-b1w25ob5 1785 3 dose dose NN cord-006856-b1w25ob5 1785 4 conditioning conditioning NN cord-006856-b1w25ob5 1785 5 consisted consist VBD cord-006856-b1w25ob5 1785 6 of of IN cord-006856-b1w25ob5 1785 7 BEAM BEAM NNP cord-006856-b1w25ob5 1785 8 chemotherapy chemotherapy NN cord-006856-b1w25ob5 1785 9 plus plus IN cord-006856-b1w25ob5 1785 10 the the DT cord-006856-b1w25ob5 1785 11 addition addition NN cord-006856-b1w25ob5 1785 12 of of IN cord-006856-b1w25ob5 1785 13 4 4 CD cord-006856-b1w25ob5 1785 14 doses dose NNS cord-006856-b1w25ob5 1785 15 of of IN cord-006856-b1w25ob5 1785 16 Rituximab Rituximab NNP cord-006856-b1w25ob5 1785 17 ( ( -LRB- cord-006856-b1w25ob5 1785 18 days day NNS cord-006856-b1w25ob5 1785 19 -9 -9 NNP cord-006856-b1w25ob5 1785 20 and and CC cord-006856-b1w25ob5 1785 21 -1 -1 NN cord-006856-b1w25ob5 1785 22 of of IN cord-006856-b1w25ob5 1785 23 the the DT cord-006856-b1w25ob5 1785 24 conditioning conditioning NN cord-006856-b1w25ob5 1785 25 regimen regimen NN cord-006856-b1w25ob5 1785 26 and and CC cord-006856-b1w25ob5 1785 27 days day NNS cord-006856-b1w25ob5 1785 28 +48 +48 NNP cord-006856-b1w25ob5 1785 29 and and CC cord-006856-b1w25ob5 1785 30 +55 +55 CD cord-006856-b1w25ob5 1785 31 after after IN cord-006856-b1w25ob5 1785 32 transplantation transplantation NN cord-006856-b1w25ob5 1785 33 ) ) -RRB- cord-006856-b1w25ob5 1785 34 . . . cord-006856-b1w25ob5 1786 1 Four four CD cord-006856-b1w25ob5 1786 2 patients patient NNS cord-006856-b1w25ob5 1786 3 could could MD cord-006856-b1w25ob5 1786 4 not not RB cord-006856-b1w25ob5 1786 5 receive receive VB cord-006856-b1w25ob5 1786 6 the the DT cord-006856-b1w25ob5 1786 7 Rituximab Rituximab NNP cord-006856-b1w25ob5 1786 8 therapy therapy NN cord-006856-b1w25ob5 1786 9 at at IN cord-006856-b1w25ob5 1786 10 days day NNS cord-006856-b1w25ob5 1786 11 +48 +48 NNP cord-006856-b1w25ob5 1786 12 and and CC cord-006856-b1w25ob5 1786 13 +55 +55 CD cord-006856-b1w25ob5 1786 14 due due IN cord-006856-b1w25ob5 1786 15 to to IN cord-006856-b1w25ob5 1786 16 complications complication NNS cord-006856-b1w25ob5 1786 17 . . . cord-006856-b1w25ob5 1787 1 A a DT cord-006856-b1w25ob5 1787 2 median median JJ cord-006856-b1w25ob5 1787 3 number number NN cord-006856-b1w25ob5 1787 4 of of IN cord-006856-b1w25ob5 1787 5 5.71 5.71 CD cord-006856-b1w25ob5 1787 6 × × NN cord-006856-b1w25ob5 1787 7 10 10 CD cord-006856-b1w25ob5 1787 8 6 6 CD cord-006856-b1w25ob5 1787 9 CD34 CD34 NNP cord-006856-b1w25ob5 1787 10 + + CC cord-006856-b1w25ob5 1787 11 cells cell NNS cord-006856-b1w25ob5 1787 12 ( ( -LRB- cord-006856-b1w25ob5 1787 13 1.65 1.65 CD cord-006856-b1w25ob5 1787 14 - - SYM cord-006856-b1w25ob5 1787 15 21.21 21.21 CD cord-006856-b1w25ob5 1787 16 ) ) -RRB- cord-006856-b1w25ob5 1787 17 per per IN cord-006856-b1w25ob5 1787 18 kg kg NNS cord-006856-b1w25ob5 1787 19 were be VBD cord-006856-b1w25ob5 1787 20 reinfused reinfuse VBN cord-006856-b1w25ob5 1787 21 . . . cord-006856-b1w25ob5 1788 1 All all DT cord-006856-b1w25ob5 1788 2 patients patient NNS cord-006856-b1w25ob5 1788 3 had have VBD cord-006856-b1w25ob5 1788 4 a a DT cord-006856-b1w25ob5 1788 5 short short JJ cord-006856-b1w25ob5 1788 6 haematologic haematologic JJ cord-006856-b1w25ob5 1788 7 regeneration regeneration NN cord-006856-b1w25ob5 1788 8 time time NN cord-006856-b1w25ob5 1788 9 ( ( -LRB- cord-006856-b1w25ob5 1788 10 granulocytes granulocyte NNS cord-006856-b1w25ob5 1788 11 , , , cord-006856-b1w25ob5 1788 12 < < XX cord-006856-b1w25ob5 1788 13 0.5 0.5 CD cord-006856-b1w25ob5 1788 14 G g NN cord-006856-b1w25ob5 1788 15 / / SYM cord-006856-b1w25ob5 1788 16 l l NN cord-006856-b1w25ob5 1788 17 day day NN cord-006856-b1w25ob5 1788 18 +10 +10 CD cord-006856-b1w25ob5 1788 19 [ [ -LRB- cord-006856-b1w25ob5 1788 20 9 9 CD cord-006856-b1w25ob5 1788 21 - - SYM cord-006856-b1w25ob5 1788 22 11 11 CD cord-006856-b1w25ob5 1788 23 ] ] -RRB- cord-006856-b1w25ob5 1788 24 ; ; : cord-006856-b1w25ob5 1788 25 platelets platelet NNS cord-006856-b1w25ob5 1788 26 , , , cord-006856-b1w25ob5 1788 27 day day NN cord-006856-b1w25ob5 1788 28 +13 +13 CD cord-006856-b1w25ob5 1788 29 [ [ -LRB- cord-006856-b1w25ob5 1788 30 10 10 CD cord-006856-b1w25ob5 1788 31 - - SYM cord-006856-b1w25ob5 1788 32 17 17 CD cord-006856-b1w25ob5 1788 33 ] ] -RRB- cord-006856-b1w25ob5 1788 34 ) ) -RRB- cord-006856-b1w25ob5 1788 35 and and CC cord-006856-b1w25ob5 1788 36 received receive VBD cord-006856-b1w25ob5 1788 37 a a DT cord-006856-b1w25ob5 1788 38 median median JJ cord-006856-b1w25ob5 1788 39 number number NN cord-006856-b1w25ob5 1788 40 of of IN cord-006856-b1w25ob5 1788 41 3 3 CD cord-006856-b1w25ob5 1788 42 erythrocyte erythrocyte NN cord-006856-b1w25ob5 1788 43 ( ( -LRB- cord-006856-b1w25ob5 1788 44 2 2 CD cord-006856-b1w25ob5 1788 45 - - SYM cord-006856-b1w25ob5 1788 46 6 6 CD cord-006856-b1w25ob5 1788 47 ) ) -RRB- cord-006856-b1w25ob5 1788 48 and and CC cord-006856-b1w25ob5 1788 49 2 2 CD cord-006856-b1w25ob5 1788 50 platelet platelet NN cord-006856-b1w25ob5 1788 51 ( ( -LRB- cord-006856-b1w25ob5 1788 52 2 2 CD cord-006856-b1w25ob5 1788 53 - - SYM cord-006856-b1w25ob5 1788 54 5 5 CD cord-006856-b1w25ob5 1788 55 ) ) -RRB- cord-006856-b1w25ob5 1788 56 concentrates concentrate VBZ cord-006856-b1w25ob5 1788 57 . . . cord-006856-b1w25ob5 1789 1 All all DT cord-006856-b1w25ob5 1789 2 patients patient NNS cord-006856-b1w25ob5 1789 3 suffered suffer VBD cord-006856-b1w25ob5 1789 4 from from IN cord-006856-b1w25ob5 1789 5 mucositis mucositis NNP cord-006856-b1w25ob5 1789 6 grade grade NNP cord-006856-b1w25ob5 1789 7 I I NNP cord-006856-b1w25ob5 1789 8 - - HYPH cord-006856-b1w25ob5 1789 9 II II NNP cord-006856-b1w25ob5 1789 10 , , , cord-006856-b1w25ob5 1789 11 3 3 CD cord-006856-b1w25ob5 1789 12 of of IN cord-006856-b1w25ob5 1789 13 10 10 CD cord-006856-b1w25ob5 1789 14 had have VBD cord-006856-b1w25ob5 1789 15 emesis emesi VBN cord-006856-b1w25ob5 1789 16 grade grade NN cord-006856-b1w25ob5 1789 17 I I NNP cord-006856-b1w25ob5 1789 18 - - HYPH cord-006856-b1w25ob5 1789 19 II II NNP cord-006856-b1w25ob5 1789 20 . . . cord-006856-b1w25ob5 1790 1 Infectious infectious JJ cord-006856-b1w25ob5 1790 2 complication complication NN cord-006856-b1w25ob5 1790 3 of of IN cord-006856-b1w25ob5 1790 4 short short JJ cord-006856-b1w25ob5 1790 5 duration duration NN cord-006856-b1w25ob5 1790 6 appeared appear VBD cord-006856-b1w25ob5 1790 7 in in IN cord-006856-b1w25ob5 1790 8 7 7 CD cord-006856-b1w25ob5 1790 9 patients patient NNS cord-006856-b1w25ob5 1790 10 ( ( -LRB- cord-006856-b1w25ob5 1790 11 4 4 CD cord-006856-b1w25ob5 1790 12 FUO fuo NN cord-006856-b1w25ob5 1790 13 , , , cord-006856-b1w25ob5 1790 14 2 2 CD cord-006856-b1w25ob5 1790 15 pneumonia pneumonia NN cord-006856-b1w25ob5 1790 16 , , , cord-006856-b1w25ob5 1790 17 and and CC cord-006856-b1w25ob5 1790 18 1 1 CD cord-006856-b1w25ob5 1790 19 sepsis sepsis NN cord-006856-b1w25ob5 1790 20 ) ) -RRB- cord-006856-b1w25ob5 1790 21 early early RB cord-006856-b1w25ob5 1790 22 after after IN cord-006856-b1w25ob5 1790 23 transplantation transplantation NN cord-006856-b1w25ob5 1790 24 . . . cord-006856-b1w25ob5 1791 1 One one CD cord-006856-b1w25ob5 1791 2 patient patient NN cord-006856-b1w25ob5 1791 3 developed develop VBD cord-006856-b1w25ob5 1791 4 late late JJ cord-006856-b1w25ob5 1791 5 complications complication NNS cord-006856-b1w25ob5 1791 6 ( ( -LRB- cord-006856-b1w25ob5 1791 7 hypothyreosis hypothyreosis NNP cord-006856-b1w25ob5 1791 8 on on IN cord-006856-b1w25ob5 1791 9 day day NN cord-006856-b1w25ob5 1791 10 +88 +88 CD cord-006856-b1w25ob5 1791 11 and and CC cord-006856-b1w25ob5 1791 12 sarcoidosis sarcoidosis NN cord-006856-b1w25ob5 1791 13 on on IN cord-006856-b1w25ob5 1791 14 day day NN cord-006856-b1w25ob5 1791 15 +105 +105 NNP cord-006856-b1w25ob5 1791 16 ) ) -RRB- cord-006856-b1w25ob5 1791 17 . . . cord-006856-b1w25ob5 1792 1 Following follow VBG cord-006856-b1w25ob5 1792 2 transplantation transplantation NN cord-006856-b1w25ob5 1792 3 , , , cord-006856-b1w25ob5 1792 4 all all DT cord-006856-b1w25ob5 1792 5 patients patient NNS cord-006856-b1w25ob5 1792 6 reached reach VBD cord-006856-b1w25ob5 1792 7 clinical clinical JJ cord-006856-b1w25ob5 1792 8 and and CC cord-006856-b1w25ob5 1792 9 molecular molecular JJ cord-006856-b1w25ob5 1792 10 CR cr NN cord-006856-b1w25ob5 1792 11 lasting last VBG cord-006856-b1w25ob5 1792 12 for for IN cord-006856-b1w25ob5 1792 13 a a DT cord-006856-b1w25ob5 1792 14 median median JJ cord-006856-b1w25ob5 1792 15 time time NN cord-006856-b1w25ob5 1792 16 of of IN cord-006856-b1w25ob5 1792 17 35 35 CD cord-006856-b1w25ob5 1792 18 ( ( -LRB- cord-006856-b1w25ob5 1792 19 1 1 CD cord-006856-b1w25ob5 1792 20 - - SYM cord-006856-b1w25ob5 1792 21 53 53 CD cord-006856-b1w25ob5 1792 22 ) ) -RRB- cord-006856-b1w25ob5 1792 23 months month NNS cord-006856-b1w25ob5 1792 24 . . . cord-006856-b1w25ob5 1793 1 Two two CD cord-006856-b1w25ob5 1793 2 patients patient NNS cord-006856-b1w25ob5 1793 3 relapsed relapse VBD cord-006856-b1w25ob5 1793 4 17 17 CD cord-006856-b1w25ob5 1793 5 and and CC cord-006856-b1w25ob5 1793 6 26 26 CD cord-006856-b1w25ob5 1793 7 months month NNS cord-006856-b1w25ob5 1793 8 after after IN cord-006856-b1w25ob5 1793 9 transplantation transplantation NN cord-006856-b1w25ob5 1793 10 . . . cord-006856-b1w25ob5 1794 1 Despite despite IN cord-006856-b1w25ob5 1794 2 continuous continuous JJ cord-006856-b1w25ob5 1794 3 salvage salvage NN cord-006856-b1w25ob5 1794 4 immunochemotherapy immunochemotherapy NN cord-006856-b1w25ob5 1794 5 , , , cord-006856-b1w25ob5 1794 6 one one CD cord-006856-b1w25ob5 1794 7 of of IN cord-006856-b1w25ob5 1794 8 these these DT cord-006856-b1w25ob5 1794 9 patients patient NNS cord-006856-b1w25ob5 1794 10 died die VBD cord-006856-b1w25ob5 1794 11 34 34 CD cord-006856-b1w25ob5 1794 12 months month NNS cord-006856-b1w25ob5 1794 13 after after IN cord-006856-b1w25ob5 1794 14 transplantation transplantation NN cord-006856-b1w25ob5 1794 15 , , , cord-006856-b1w25ob5 1794 16 the the DT cord-006856-b1w25ob5 1794 17 other other JJ cord-006856-b1w25ob5 1794 18 one one NN cord-006856-b1w25ob5 1794 19 is be VBZ cord-006856-b1w25ob5 1794 20 still still RB cord-006856-b1w25ob5 1794 21 in in IN cord-006856-b1w25ob5 1794 22 PR PR NNP cord-006856-b1w25ob5 1794 23 ( ( -LRB- cord-006856-b1w25ob5 1794 24 +48 +48 NNP cord-006856-b1w25ob5 1794 25 months month NNS cord-006856-b1w25ob5 1794 26 ) ) -RRB- cord-006856-b1w25ob5 1794 27 . . . cord-006856-b1w25ob5 1795 1 Median median JJ cord-006856-b1w25ob5 1795 2 observation observation NN cord-006856-b1w25ob5 1795 3 periode periode NN cord-006856-b1w25ob5 1795 4 after after IN cord-006856-b1w25ob5 1795 5 diagnosis diagnosis NN cord-006856-b1w25ob5 1795 6 is be VBZ cord-006856-b1w25ob5 1795 7 46 46 CD cord-006856-b1w25ob5 1795 8 ( ( -LRB- cord-006856-b1w25ob5 1795 9 11 11 CD cord-006856-b1w25ob5 1795 10 - - SYM cord-006856-b1w25ob5 1795 11 105 105 CD cord-006856-b1w25ob5 1795 12 ) ) -RRB- cord-006856-b1w25ob5 1795 13 months month NNS cord-006856-b1w25ob5 1795 14 . . . cord-006856-b1w25ob5 1796 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1796 2 . . . cord-006856-b1w25ob5 1797 1 Treatment treatment NN cord-006856-b1w25ob5 1797 2 intensification intensification NN cord-006856-b1w25ob5 1797 3 with with IN cord-006856-b1w25ob5 1797 4 immunochemotherapy immunochemotherapy NN cord-006856-b1w25ob5 1797 5 and and CC cord-006856-b1w25ob5 1797 6 high high JJ cord-006856-b1w25ob5 1797 7 - - HYPH cord-006856-b1w25ob5 1797 8 dose dose NN cord-006856-b1w25ob5 1797 9 consolidation consolidation NN cord-006856-b1w25ob5 1797 10 is be VBZ cord-006856-b1w25ob5 1797 11 accompanied accompany VBN cord-006856-b1w25ob5 1797 12 by by IN cord-006856-b1w25ob5 1797 13 acceptable acceptable JJ cord-006856-b1w25ob5 1797 14 toxicity toxicity NN cord-006856-b1w25ob5 1797 15 and and CC cord-006856-b1w25ob5 1797 16 seems seem VBZ cord-006856-b1w25ob5 1797 17 to to TO cord-006856-b1w25ob5 1797 18 be be VB cord-006856-b1w25ob5 1797 19 an an DT cord-006856-b1w25ob5 1797 20 effective effective JJ cord-006856-b1w25ob5 1797 21 treatment treatment NN cord-006856-b1w25ob5 1797 22 procedure procedure NN cord-006856-b1w25ob5 1797 23 for for IN cord-006856-b1w25ob5 1797 24 mantle mantle NN cord-006856-b1w25ob5 1797 25 cell cell NN cord-006856-b1w25ob5 1797 26 lymphoma lymphoma NN cord-006856-b1w25ob5 1797 27 . . . cord-006856-b1w25ob5 1798 1 Background background NN cord-006856-b1w25ob5 1798 2 . . . cord-006856-b1w25ob5 1799 1 Bone bone NN cord-006856-b1w25ob5 1799 2 marrow marrow NN cord-006856-b1w25ob5 1799 3 transplantation transplantation NN cord-006856-b1w25ob5 1799 4 ( ( -LRB- cord-006856-b1w25ob5 1799 5 BMT BMT NNP cord-006856-b1w25ob5 1799 6 ) ) -RRB- cord-006856-b1w25ob5 1799 7 together together RB cord-006856-b1w25ob5 1799 8 with with IN cord-006856-b1w25ob5 1799 9 costimulation costimulation NN cord-006856-b1w25ob5 1799 10 blockade blockade NN cord-006856-b1w25ob5 1799 11 can can MD cord-006856-b1w25ob5 1799 12 reliably reliably RB cord-006856-b1w25ob5 1799 13 induce induce VB cord-006856-b1w25ob5 1799 14 mixed mixed JJ cord-006856-b1w25ob5 1799 15 chimerism chimerism NN cord-006856-b1w25ob5 1799 16 and and CC cord-006856-b1w25ob5 1799 17 tolerance tolerance NN cord-006856-b1w25ob5 1799 18 . . . cord-006856-b1w25ob5 1800 1 In in IN cord-006856-b1w25ob5 1800 2 recent recent JJ cord-006856-b1w25ob5 1800 3 studies study NNS cord-006856-b1w25ob5 1800 4 , , , cord-006856-b1w25ob5 1800 5 we -PRON- PRP cord-006856-b1w25ob5 1800 6 showed show VBD cord-006856-b1w25ob5 1800 7 that that IN cord-006856-b1w25ob5 1800 8 regulation regulation NN cord-006856-b1w25ob5 1800 9 by by IN cord-006856-b1w25ob5 1800 10 CD4 CD4 NNP cord-006856-b1w25ob5 1800 11 + + CC cord-006856-b1w25ob5 1800 12 CD25 CD25 NNP cord-006856-b1w25ob5 1801 1 + + CC cord-006856-b1w25ob5 1801 2 T t NN cord-006856-b1w25ob5 1801 3 cells cell NNS cord-006856-b1w25ob5 1801 4 plays play VBZ cord-006856-b1w25ob5 1801 5 an an DT cord-006856-b1w25ob5 1801 6 important important JJ cord-006856-b1w25ob5 1801 7 role role NN cord-006856-b1w25ob5 1801 8 in in IN cord-006856-b1w25ob5 1801 9 this this DT cord-006856-b1w25ob5 1801 10 model model NN cord-006856-b1w25ob5 1801 11 . . . cord-006856-b1w25ob5 1802 1 Stimulation stimulation NN cord-006856-b1w25ob5 1802 2 of of IN cord-006856-b1w25ob5 1802 3 CD4 CD4 NNP cord-006856-b1w25ob5 1802 4 + + CC cord-006856-b1w25ob5 1802 5 CD25 CD25 NNP cord-006856-b1w25ob5 1802 6 + + CC cord-006856-b1w25ob5 1802 7 T t NN cord-006856-b1w25ob5 1802 8 regs reg NNS cord-006856-b1w25ob5 1802 9 by by IN cord-006856-b1w25ob5 1802 10 an an DT cord-006856-b1w25ob5 1802 11 anti anti JJ cord-006856-b1w25ob5 1802 12 - - JJ cord-006856-b1w25ob5 1802 13 CD3 cd3 JJ cord-006856-b1w25ob5 1802 14 mAb mab NN cord-006856-b1w25ob5 1803 1 can can MD cord-006856-b1w25ob5 1803 2 inhibit inhibit VB cord-006856-b1w25ob5 1803 3 and and CC cord-006856-b1w25ob5 1803 4 reverse reverse VB cord-006856-b1w25ob5 1803 5 the the DT cord-006856-b1w25ob5 1803 6 outbreak outbreak NN cord-006856-b1w25ob5 1803 7 of of IN cord-006856-b1w25ob5 1803 8 certain certain JJ cord-006856-b1w25ob5 1803 9 autoimmune autoimmune JJ cord-006856-b1w25ob5 1803 10 diseases disease NNS cord-006856-b1w25ob5 1803 11 , , , cord-006856-b1w25ob5 1803 12 and and CC cord-006856-b1w25ob5 1803 13 the the DT cord-006856-b1w25ob5 1803 14 maintenance maintenance NN cord-006856-b1w25ob5 1803 15 and and CC cord-006856-b1w25ob5 1803 16 function function NN cord-006856-b1w25ob5 1803 17 of of IN cord-006856-b1w25ob5 1803 18 T T NNP cord-006856-b1w25ob5 1803 19 regs reg NNS cord-006856-b1w25ob5 1803 20 was be VBD cord-006856-b1w25ob5 1803 21 demonstrated demonstrate VBN cord-006856-b1w25ob5 1803 22 to to TO cord-006856-b1w25ob5 1803 23 critically critically RB cord-006856-b1w25ob5 1803 24 depend depend VB cord-006856-b1w25ob5 1803 25 on on IN cord-006856-b1w25ob5 1803 26 IL-2 IL-2 NNP cord-006856-b1w25ob5 1803 27 . . . cord-006856-b1w25ob5 1804 1 We -PRON- PRP cord-006856-b1w25ob5 1804 2 thus thus RB cord-006856-b1w25ob5 1804 3 investigated investigate VBD cord-006856-b1w25ob5 1804 4 if if IN cord-006856-b1w25ob5 1804 5 stimulation stimulation NN cord-006856-b1w25ob5 1804 6 of of IN cord-006856-b1w25ob5 1804 7 regulatory regulatory JJ cord-006856-b1w25ob5 1804 8 cells cell NNS cord-006856-b1w25ob5 1804 9 by by IN cord-006856-b1w25ob5 1804 10 anti anti JJ cord-006856-b1w25ob5 1804 11 - - JJ cord-006856-b1w25ob5 1804 12 CD3 cd3 JJ cord-006856-b1w25ob5 1804 13 or or CC cord-006856-b1w25ob5 1804 14 interleukin-2 interleukin-2 NN cord-006856-b1w25ob5 1804 15 facilitates facilitate VBZ cord-006856-b1w25ob5 1804 16 BM BM NNP cord-006856-b1w25ob5 1804 17 engraftment engraftment NN cord-006856-b1w25ob5 1804 18 and and CC cord-006856-b1w25ob5 1804 19 reduction reduction NN cord-006856-b1w25ob5 1804 20 of of IN cord-006856-b1w25ob5 1804 21 TBI TBI NNP cord-006856-b1w25ob5 1804 22 in in IN cord-006856-b1w25ob5 1804 23 our -PRON- PRP$ cord-006856-b1w25ob5 1804 24 model model NN cord-006856-b1w25ob5 1804 25 . . . cord-006856-b1w25ob5 1805 1 Methods method NNS cord-006856-b1w25ob5 1805 2 . . . cord-006856-b1w25ob5 1806 1 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1807 1 mice mouse NNS cord-006856-b1w25ob5 1807 2 received receive VBD cord-006856-b1w25ob5 1807 3 a a DT cord-006856-b1w25ob5 1807 4 total total JJ cord-006856-b1w25ob5 1807 5 - - HYPH cord-006856-b1w25ob5 1807 6 body body NN cord-006856-b1w25ob5 1807 7 irradiation irradiation NN cord-006856-b1w25ob5 1807 8 ( ( -LRB- cord-006856-b1w25ob5 1807 9 day day NN cord-006856-b1w25ob5 1807 10 -1 -1 NN cord-006856-b1w25ob5 1807 11 ) ) -RRB- cord-006856-b1w25ob5 1807 12 of of IN cord-006856-b1w25ob5 1807 13 3 3 CD cord-006856-b1w25ob5 1807 14 Gy Gy NNP cord-006856-b1w25ob5 1807 15 or or CC cord-006856-b1w25ob5 1807 16 1.5 1.5 CD cord-006856-b1w25ob5 1807 17 Gy Gy NNP cord-006856-b1w25ob5 1807 18 , , , cord-006856-b1w25ob5 1807 19 approximately approximately RB cord-006856-b1w25ob5 1807 20 20 20 CD cord-006856-b1w25ob5 1807 21 × × NN cord-006856-b1w25ob5 1807 22 10 10 CD cord-006856-b1w25ob5 1807 23 6 6 CD cord-006856-b1w25ob5 1807 24 fully fully RB cord-006856-b1w25ob5 1807 25 mismatched mismatched JJ cord-006856-b1w25ob5 1807 26 BALB BALB NNP cord-006856-b1w25ob5 1807 27 / / SYM cord-006856-b1w25ob5 1807 28 c c NN cord-006856-b1w25ob5 1807 29 bone bone NN cord-006856-b1w25ob5 1807 30 marrow marrow NN cord-006856-b1w25ob5 1807 31 cells cell NNS cord-006856-b1w25ob5 1807 32 ( ( -LRB- cord-006856-b1w25ob5 1807 33 day day NN cord-006856-b1w25ob5 1807 34 0 0 CD cord-006856-b1w25ob5 1807 35 ) ) -RRB- cord-006856-b1w25ob5 1807 36 and and CC cord-006856-b1w25ob5 1807 37 costimulation costimulation NN cord-006856-b1w25ob5 1807 38 blockade blockade NN cord-006856-b1w25ob5 1807 39 consisting consist VBG cord-006856-b1w25ob5 1807 40 of of IN cord-006856-b1w25ob5 1807 41 anti anti JJ cord-006856-b1w25ob5 1807 42 - - JJ cord-006856-b1w25ob5 1807 43 CD154 cd154 CD cord-006856-b1w25ob5 1807 44 mAb mAb NNS cord-006856-b1w25ob5 1807 45 ( ( -LRB- cord-006856-b1w25ob5 1807 46 MR1 MR1 NNP cord-006856-b1w25ob5 1807 47 , , , cord-006856-b1w25ob5 1807 48 day day NN cord-006856-b1w25ob5 1807 49 0 0 CD cord-006856-b1w25ob5 1807 50 ) ) -RRB- cord-006856-b1w25ob5 1807 51 and and CC cord-006856-b1w25ob5 1807 52 CTLA4Ig CTLA4Ig NNP cord-006856-b1w25ob5 1807 53 ( ( -LRB- cord-006856-b1w25ob5 1807 54 day day NN cord-006856-b1w25ob5 1807 55 +2 +2 CD cord-006856-b1w25ob5 1807 56 ) ) -RRB- cord-006856-b1w25ob5 1807 57 . . . cord-006856-b1w25ob5 1808 1 Additional additional JJ cord-006856-b1w25ob5 1808 2 groups group NNS cord-006856-b1w25ob5 1808 3 received receive VBD cord-006856-b1w25ob5 1808 4 further further JJ cord-006856-b1w25ob5 1808 5 treatment treatment NN cord-006856-b1w25ob5 1808 6 with with IN cord-006856-b1w25ob5 1808 7 ( ( -LRB- cord-006856-b1w25ob5 1808 8 n n NN cord-006856-b1w25ob5 1808 9 = = SYM cord-006856-b1w25ob5 1808 10 4 4 CD cord-006856-b1w25ob5 1808 11 - - SYM cord-006856-b1w25ob5 1808 12 8 8 CD cord-006856-b1w25ob5 1808 13 per per IN cord-006856-b1w25ob5 1808 14 group group NN cord-006856-b1w25ob5 1808 15 ) ) -RRB- cord-006856-b1w25ob5 1808 16 : : : cord-006856-b1w25ob5 1808 17 ( ( -LRB- cord-006856-b1w25ob5 1808 18 1 1 LS cord-006856-b1w25ob5 1808 19 ) ) -RRB- cord-006856-b1w25ob5 1808 20 anti anti JJ cord-006856-b1w25ob5 1808 21 - - JJ cord-006856-b1w25ob5 1808 22 CD3 cd3 JJ cord-006856-b1w25ob5 1808 23 mAb mAb NNS cord-006856-b1w25ob5 1808 24 ( ( -LRB- cord-006856-b1w25ob5 1808 25 5 5 CD cord-006856-b1w25ob5 1808 26 µg µg NN cord-006856-b1w25ob5 1808 27 , , , cord-006856-b1w25ob5 1808 28 day day NN cord-006856-b1w25ob5 1808 29 0 0 CD cord-006856-b1w25ob5 1808 30 to to IN cord-006856-b1w25ob5 1808 31 +4 +4 LS cord-006856-b1w25ob5 1808 32 ) ) -RRB- cord-006856-b1w25ob5 1808 33 , , , cord-006856-b1w25ob5 1808 34 ( ( -LRB- cord-006856-b1w25ob5 1808 35 2 2 LS cord-006856-b1w25ob5 1808 36 ) ) -RRB- cord-006856-b1w25ob5 1808 37 IL-2 il-2 NN cord-006856-b1w25ob5 1808 38 ( ( -LRB- cord-006856-b1w25ob5 1808 39 4000 4000 CD cord-006856-b1w25ob5 1808 40 IE IE NNP cord-006856-b1w25ob5 1808 41 / / SYM cord-006856-b1w25ob5 1808 42 day day NN cord-006856-b1w25ob5 1808 43 , , , cord-006856-b1w25ob5 1808 44 day day NN cord-006856-b1w25ob5 1808 45 0 0 CD cord-006856-b1w25ob5 1808 46 - - HYPH cord-006856-b1w25ob5 1808 47 27 27 CD cord-006856-b1w25ob5 1808 48 ) ) -RRB- cord-006856-b1w25ob5 1808 49 , , , cord-006856-b1w25ob5 1808 50 ( ( -LRB- cord-006856-b1w25ob5 1808 51 3 3 LS cord-006856-b1w25ob5 1808 52 ) ) -RRB- cord-006856-b1w25ob5 1808 53 rapamycin rapamycin NNP cord-006856-b1w25ob5 1808 54 ( ( -LRB- cord-006856-b1w25ob5 1808 55 0.3 0.3 CD cord-006856-b1w25ob5 1808 56 mg mg NNP cord-006856-b1w25ob5 1808 57 / / SYM cord-006856-b1w25ob5 1808 58 kg kg NNP cord-006856-b1w25ob5 1809 1 /day /day NFP cord-006856-b1w25ob5 1809 2 , , , cord-006856-b1w25ob5 1809 3 day day NN cord-006856-b1w25ob5 1809 4 0 0 CD cord-006856-b1w25ob5 1809 5 - - HYPH cord-006856-b1w25ob5 1809 6 27 27 CD cord-006856-b1w25ob5 1809 7 ) ) -RRB- cord-006856-b1w25ob5 1809 8 , , , cord-006856-b1w25ob5 1809 9 and and CC cord-006856-b1w25ob5 1809 10 ( ( -LRB- cord-006856-b1w25ob5 1809 11 4 4 LS cord-006856-b1w25ob5 1809 12 ) ) -RRB- cord-006856-b1w25ob5 1809 13 rapamycin rapamycin NN cord-006856-b1w25ob5 1809 14 and and CC cord-006856-b1w25ob5 1809 15 IL-2 IL-2 NNP cord-006856-b1w25ob5 1809 16 ( ( -LRB- cord-006856-b1w25ob5 1809 17 day day NN cord-006856-b1w25ob5 1809 18 0 0 CD cord-006856-b1w25ob5 1809 19 - - HYPH cord-006856-b1w25ob5 1809 20 27 27 CD cord-006856-b1w25ob5 1809 21 ) ) -RRB- cord-006856-b1w25ob5 1809 22 . . . cord-006856-b1w25ob5 1810 1 Multilinage multilinage NN cord-006856-b1w25ob5 1810 2 chimerism chimerism NN cord-006856-b1w25ob5 1810 3 and and CC cord-006856-b1w25ob5 1810 4 skin skin NN cord-006856-b1w25ob5 1810 5 graft graft NN cord-006856-b1w25ob5 1810 6 survival survival NN cord-006856-b1w25ob5 1810 7 were be VBD cord-006856-b1w25ob5 1810 8 followed follow VBN cord-006856-b1w25ob5 1810 9 for for IN cord-006856-b1w25ob5 1810 10 more more JJR cord-006856-b1w25ob5 1810 11 than than IN cord-006856-b1w25ob5 1810 12 120 120 CD cord-006856-b1w25ob5 1810 13 days day NNS cord-006856-b1w25ob5 1810 14 . . . cord-006856-b1w25ob5 1811 1 Results result NNS cord-006856-b1w25ob5 1811 2 . . . cord-006856-b1w25ob5 1812 1 With with IN cord-006856-b1w25ob5 1812 2 our -PRON- PRP$ cord-006856-b1w25ob5 1812 3 standard standard JJ cord-006856-b1w25ob5 1812 4 protocol protocol NN cord-006856-b1w25ob5 1812 5 , , , cord-006856-b1w25ob5 1812 6 10 10 CD cord-006856-b1w25ob5 1812 7 of of IN cord-006856-b1w25ob5 1812 8 10 10 CD cord-006856-b1w25ob5 1812 9 ( ( -LRB- cord-006856-b1w25ob5 1812 10 3 3 CD cord-006856-b1w25ob5 1812 11 Gy Gy NNP cord-006856-b1w25ob5 1812 12 ) ) -RRB- cord-006856-b1w25ob5 1812 13 and and CC cord-006856-b1w25ob5 1812 14 8 8 CD cord-006856-b1w25ob5 1812 15 of of IN cord-006856-b1w25ob5 1812 16 14 14 CD cord-006856-b1w25ob5 1812 17 ( ( -LRB- cord-006856-b1w25ob5 1812 18 1.5 1.5 CD cord-006856-b1w25ob5 1812 19 Gy Gy NNP cord-006856-b1w25ob5 1812 20 ) ) -RRB- cord-006856-b1w25ob5 1812 21 mice mouse NNS cord-006856-b1w25ob5 1812 22 developed develop VBD cord-006856-b1w25ob5 1812 23 long long JJ cord-006856-b1w25ob5 1812 24 - - HYPH cord-006856-b1w25ob5 1812 25 term term NN cord-006856-b1w25ob5 1812 26 multilinage multilinage NN cord-006856-b1w25ob5 1812 27 chimerism chimerism NN cord-006856-b1w25ob5 1812 28 and and CC cord-006856-b1w25ob5 1812 29 accepted accepted JJ cord-006856-b1w25ob5 1812 30 donor donor NN cord-006856-b1w25ob5 1812 31 skin skin NN cord-006856-b1w25ob5 1812 32 grafts graft NNS cord-006856-b1w25ob5 1812 33 permanently permanently RB cord-006856-b1w25ob5 1812 34 . . . cord-006856-b1w25ob5 1813 1 While while IN cord-006856-b1w25ob5 1813 2 the the DT cord-006856-b1w25ob5 1813 3 majority majority NN cord-006856-b1w25ob5 1813 4 of of IN cord-006856-b1w25ob5 1813 5 mice mouse NNS cord-006856-b1w25ob5 1813 6 treated treat VBN cord-006856-b1w25ob5 1813 7 with with IN cord-006856-b1w25ob5 1813 8 anti anti JJ cord-006856-b1w25ob5 1813 9 - - JJ cord-006856-b1w25ob5 1813 10 CD3 cd3 JJ cord-006856-b1w25ob5 1813 11 and and CC cord-006856-b1w25ob5 1813 12 3 3 CD cord-006856-b1w25ob5 1813 13 Gy Gy NNP cord-006856-b1w25ob5 1813 14 ( ( -LRB- cord-006856-b1w25ob5 1813 15 7 7 CD cord-006856-b1w25ob5 1813 16 of of IN cord-006856-b1w25ob5 1813 17 8) 8) NN cord-006856-b1w25ob5 1813 18 , , , cord-006856-b1w25ob5 1813 19 rapamycin rapamycin NNS cord-006856-b1w25ob5 1813 20 plus plus CC cord-006856-b1w25ob5 1813 21 1.5 1.5 CD cord-006856-b1w25ob5 1813 22 Gy Gy NNP cord-006856-b1w25ob5 1813 23 ( ( -LRB- cord-006856-b1w25ob5 1813 24 4 4 CD cord-006856-b1w25ob5 1813 25 of of IN cord-006856-b1w25ob5 1813 26 6 6 CD cord-006856-b1w25ob5 1813 27 ) ) -RRB- cord-006856-b1w25ob5 1813 28 , , , cord-006856-b1w25ob5 1813 29 and and CC cord-006856-b1w25ob5 1813 30 IL-2 il-2 NN cord-006856-b1w25ob5 1813 31 and and CC cord-006856-b1w25ob5 1813 32 rapamycin rapamycin VBD cord-006856-b1w25ob5 1813 33 plus plus CC cord-006856-b1w25ob5 1813 34 1.5 1.5 CD cord-006856-b1w25ob5 1813 35 Gy Gy NNP cord-006856-b1w25ob5 1813 36 ( ( -LRB- cord-006856-b1w25ob5 1813 37 4 4 CD cord-006856-b1w25ob5 1813 38 of of IN cord-006856-b1w25ob5 1813 39 5 5 CD cord-006856-b1w25ob5 1813 40 ) ) -RRB- cord-006856-b1w25ob5 1813 41 developed develop VBN cord-006856-b1w25ob5 1813 42 multilinage multilinage NN cord-006856-b1w25ob5 1813 43 chimerism chimerism NN cord-006856-b1w25ob5 1813 44 and and CC cord-006856-b1w25ob5 1813 45 longterm longterm JJ cord-006856-b1w25ob5 1813 46 skin skin NN cord-006856-b1w25ob5 1813 47 graft graft NN cord-006856-b1w25ob5 1813 48 survival survival NN cord-006856-b1w25ob5 1813 49 , , , cord-006856-b1w25ob5 1813 50 groups group NNS cord-006856-b1w25ob5 1813 51 treated treat VBN cord-006856-b1w25ob5 1813 52 with with IN cord-006856-b1w25ob5 1813 53 anti anti JJ cord-006856-b1w25ob5 1813 54 - - JJ cord-006856-b1w25ob5 1813 55 CD3 cd3 JJ cord-006856-b1w25ob5 1813 56 plus plus CC cord-006856-b1w25ob5 1813 57 1.5 1.5 CD cord-006856-b1w25ob5 1813 58 Gy Gy NNP cord-006856-b1w25ob5 1813 59 TBI TBI NNP cord-006856-b1w25ob5 1813 60 ( ( -LRB- cord-006856-b1w25ob5 1813 61 0 0 CD cord-006856-b1w25ob5 1813 62 of of IN cord-006856-b1w25ob5 1813 63 8 8 CD cord-006856-b1w25ob5 1813 64 , , , cord-006856-b1w25ob5 1813 65 P p NN cord-006856-b1w25ob5 1813 66 < < XX cord-006856-b1w25ob5 1813 67 0.01 0.01 CD cord-006856-b1w25ob5 1813 68 ) ) -RRB- cord-006856-b1w25ob5 1813 69 and and CC cord-006856-b1w25ob5 1813 70 IL-2 IL-2 NNP cord-006856-b1w25ob5 1813 71 plus plus CC cord-006856-b1w25ob5 1813 72 1.5 1.5 CD cord-006856-b1w25ob5 1813 73 Gy Gy NNP cord-006856-b1w25ob5 1813 74 ( ( -LRB- cord-006856-b1w25ob5 1813 75 2 2 CD cord-006856-b1w25ob5 1813 76 of of IN cord-006856-b1w25ob5 1813 77 6 6 CD cord-006856-b1w25ob5 1813 78 , , , cord-006856-b1w25ob5 1813 79 P p NN cord-006856-b1w25ob5 1813 80 = = SYM cord-006856-b1w25ob5 1813 81 0.1 0.1 CD cord-006856-b1w25ob5 1813 82 ) ) -RRB- cord-006856-b1w25ob5 1813 83 showed show VBD cord-006856-b1w25ob5 1813 84 markedly markedly RB cord-006856-b1w25ob5 1813 85 reduced reduce VBN cord-006856-b1w25ob5 1813 86 rates rate NNS cord-006856-b1w25ob5 1813 87 of of IN cord-006856-b1w25ob5 1813 88 chimerism chimerism NN cord-006856-b1w25ob5 1813 89 and and CC cord-006856-b1w25ob5 1813 90 tolerance tolerance NN cord-006856-b1w25ob5 1813 91 . . . cord-006856-b1w25ob5 1814 1 We -PRON- PRP cord-006856-b1w25ob5 1814 2 investigated investigate VBD cord-006856-b1w25ob5 1814 3 if if IN cord-006856-b1w25ob5 1814 4 these these DT cord-006856-b1w25ob5 1814 5 negative negative JJ cord-006856-b1w25ob5 1814 6 effects effect NNS cord-006856-b1w25ob5 1814 7 might may MD cord-006856-b1w25ob5 1814 8 be be VB cord-006856-b1w25ob5 1814 9 correlated correlate VBN cord-006856-b1w25ob5 1814 10 with with IN cord-006856-b1w25ob5 1814 11 a a DT cord-006856-b1w25ob5 1814 12 cytokine cytokine JJ cord-006856-b1w25ob5 1814 13 shift shift NN cord-006856-b1w25ob5 1814 14 caused cause VBN cord-006856-b1w25ob5 1814 15 by by IN cord-006856-b1w25ob5 1814 16 anti anti JJ cord-006856-b1w25ob5 1814 17 - - JJ cord-006856-b1w25ob5 1814 18 CD3 cd3 JJ cord-006856-b1w25ob5 1814 19 treatment treatment NN cord-006856-b1w25ob5 1814 20 , , , cord-006856-b1w25ob5 1814 21 but but CC cord-006856-b1w25ob5 1814 22 we -PRON- PRP cord-006856-b1w25ob5 1814 23 did do VBD cord-006856-b1w25ob5 1814 24 not not RB cord-006856-b1w25ob5 1814 25 observe observe VB cord-006856-b1w25ob5 1814 26 such such PDT cord-006856-b1w25ob5 1814 27 a a DT cord-006856-b1w25ob5 1814 28 shift shift NN cord-006856-b1w25ob5 1814 29 towards towards IN cord-006856-b1w25ob5 1814 30 Th1 th1 NN cord-006856-b1w25ob5 1814 31 or or CC cord-006856-b1w25ob5 1814 32 Th2 Th2 NNP cord-006856-b1w25ob5 1814 33 ( ( -LRB- cord-006856-b1w25ob5 1814 34 as as IN cord-006856-b1w25ob5 1814 35 measured measure VBN cord-006856-b1w25ob5 1814 36 on on IN cord-006856-b1w25ob5 1814 37 day day NN cord-006856-b1w25ob5 1814 38 13 13 CD cord-006856-b1w25ob5 1814 39 post post NN cord-006856-b1w25ob5 1814 40 - - JJ cord-006856-b1w25ob5 1814 41 BMT BMT NNP cord-006856-b1w25ob5 1814 42 ) ) -RRB- cord-006856-b1w25ob5 1814 43 . . . cord-006856-b1w25ob5 1815 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1815 2 . . . cord-006856-b1w25ob5 1816 1 Unexpectedly unexpectedly RB cord-006856-b1w25ob5 1816 2 neither neither DT cord-006856-b1w25ob5 1816 3 anti anti JJ cord-006856-b1w25ob5 1816 4 - - JJ cord-006856-b1w25ob5 1816 5 CD3 cd3 JJ cord-006856-b1w25ob5 1816 6 nor nor CC cord-006856-b1w25ob5 1816 7 IL-2 IL-2 NNP cord-006856-b1w25ob5 1816 8 had have VBD cord-006856-b1w25ob5 1816 9 a a DT cord-006856-b1w25ob5 1816 10 positive positive JJ cord-006856-b1w25ob5 1816 11 effect effect NN cord-006856-b1w25ob5 1816 12 in in IN cord-006856-b1w25ob5 1816 13 this this DT cord-006856-b1w25ob5 1816 14 model model NN cord-006856-b1w25ob5 1816 15 , , , cord-006856-b1w25ob5 1816 16 in in IN cord-006856-b1w25ob5 1816 17 some some DT cord-006856-b1w25ob5 1816 18 groups group NNS cord-006856-b1w25ob5 1816 19 anti anti JJ cord-006856-b1w25ob5 1816 20 - - JJ cord-006856-b1w25ob5 1816 21 CD3 cd3 JJ cord-006856-b1w25ob5 1816 22 treatment treatment NN cord-006856-b1w25ob5 1816 23 even even RB cord-006856-b1w25ob5 1816 24 showed show VBD cord-006856-b1w25ob5 1816 25 a a DT cord-006856-b1w25ob5 1816 26 negative negative JJ cord-006856-b1w25ob5 1816 27 effect effect NN cord-006856-b1w25ob5 1816 28 . . . cord-006856-b1w25ob5 1817 1 Thus thus RB cord-006856-b1w25ob5 1817 2 , , , cord-006856-b1w25ob5 1817 3 other other JJ cord-006856-b1w25ob5 1817 4 strategies strategy NNS cord-006856-b1w25ob5 1817 5 for for IN cord-006856-b1w25ob5 1817 6 augmenting augment VBG cord-006856-b1w25ob5 1817 7 the the DT cord-006856-b1w25ob5 1817 8 effect effect NN cord-006856-b1w25ob5 1817 9 of of IN cord-006856-b1w25ob5 1817 10 regulatory regulatory JJ cord-006856-b1w25ob5 1817 11 cells cell NNS cord-006856-b1w25ob5 1817 12 need need VBP cord-006856-b1w25ob5 1817 13 to to TO cord-006856-b1w25ob5 1817 14 be be VB cord-006856-b1w25ob5 1817 15 developed develop VBN cord-006856-b1w25ob5 1817 16 . . . cord-006856-b1w25ob5 1818 1 The the DT cord-006856-b1w25ob5 1818 2 role role NN cord-006856-b1w25ob5 1818 3 of of IN cord-006856-b1w25ob5 1818 4 minor minor JJ cord-006856-b1w25ob5 1818 5 antigen antigen NN cord-006856-b1w25ob5 1818 6 disparities disparity NNS cord-006856-b1w25ob5 1818 7 for for IN cord-006856-b1w25ob5 1818 8 the the DT cord-006856-b1w25ob5 1818 9 induction induction NN cord-006856-b1w25ob5 1818 10 of of IN cord-006856-b1w25ob5 1818 11 mixed mixed JJ cord-006856-b1w25ob5 1818 12 chimerism chimerism NN cord-006856-b1w25ob5 1818 13 and and CC cord-006856-b1w25ob5 1818 14 tolerance tolerance NN cord-006856-b1w25ob5 1818 15 through through IN cord-006856-b1w25ob5 1818 16 BMT BMT NNP cord-006856-b1w25ob5 1818 17 plus plus CC cord-006856-b1w25ob5 1818 18 costimulation costimulation NN cord-006856-b1w25ob5 1818 19 blockade blockade NN cord-006856-b1w25ob5 1818 20 S. S. NNP cord-006856-b1w25ob5 1818 21 Bigenzahn Bigenzahn NNP cord-006856-b1w25ob5 1818 22 1 1 CD cord-006856-b1w25ob5 1818 23 , , , cord-006856-b1w25ob5 1818 24 I. I. NNP cord-006856-b1w25ob5 1818 25 Pree Pree NNP cord-006856-b1w25ob5 1818 26 1 1 CD cord-006856-b1w25ob5 1818 27 , , , cord-006856-b1w25ob5 1818 28 P. P. NNP cord-006856-b1w25ob5 1818 29 Nierlich Nierlich NNP cord-006856-b1w25ob5 1818 30 1 1 CD cord-006856-b1w25ob5 1818 31 , , , cord-006856-b1w25ob5 1818 32 E. E. NNP cord-006856-b1w25ob5 1818 33 Selzer Selzer NNP cord-006856-b1w25ob5 1818 34 2 2 CD cord-006856-b1w25ob5 1818 35 , , , cord-006856-b1w25ob5 1818 36 F. F. NNP cord-006856-b1w25ob5 1818 37 Mühlbacher Mühlbacher NNP cord-006856-b1w25ob5 1818 38 1 1 CD cord-006856-b1w25ob5 1818 39 , , , cord-006856-b1w25ob5 1818 40 T. T. NNP cord-006856-b1w25ob5 1818 41 Wekerle Wekerle NNP cord-006856-b1w25ob5 1818 42 1 1 CD cord-006856-b1w25ob5 1818 43 long long JJ cord-006856-b1w25ob5 1818 44 - - HYPH cord-006856-b1w25ob5 1818 45 term term NN cord-006856-b1w25ob5 1818 46 donor donor NN cord-006856-b1w25ob5 1818 47 skin skin NN cord-006856-b1w25ob5 1818 48 grafts graft NNS cord-006856-b1w25ob5 1818 49 looked look VBD cord-006856-b1w25ob5 1818 50 macroscopically macroscopically RB cord-006856-b1w25ob5 1818 51 intact intact JJ cord-006856-b1w25ob5 1818 52 in in IN cord-006856-b1w25ob5 1818 53 the the DT cord-006856-b1w25ob5 1818 54 B10.D2 B10.D2 NNP cord-006856-b1w25ob5 1818 55 group group NN cord-006856-b1w25ob5 1818 56 but but CC cord-006856-b1w25ob5 1818 57 showed show VBD cord-006856-b1w25ob5 1818 58 shrinking shrink VBG cord-006856-b1w25ob5 1818 59 and and CC cord-006856-b1w25ob5 1818 60 scabs scab NNS cord-006856-b1w25ob5 1818 61 in in IN cord-006856-b1w25ob5 1818 62 the the DT cord-006856-b1w25ob5 1818 63 BALB BALB NNP cord-006856-b1w25ob5 1818 64 / / SYM cord-006856-b1w25ob5 1818 65 c c NNP cord-006856-b1w25ob5 1818 66 group group NN cord-006856-b1w25ob5 1818 67 . . . cord-006856-b1w25ob5 1819 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1819 2 . . . cord-006856-b1w25ob5 1820 1 Minor minor JJ cord-006856-b1w25ob5 1820 2 antigen antigen NN cord-006856-b1w25ob5 1820 3 disparities disparity NNS cord-006856-b1w25ob5 1820 4 pose pose VBP cord-006856-b1w25ob5 1820 5 a a DT cord-006856-b1w25ob5 1820 6 substantial substantial JJ cord-006856-b1w25ob5 1820 7 barrier barrier NN cord-006856-b1w25ob5 1820 8 for for IN cord-006856-b1w25ob5 1820 9 the the DT cord-006856-b1w25ob5 1820 10 induction induction NN cord-006856-b1w25ob5 1820 11 of of IN cord-006856-b1w25ob5 1820 12 mixed mixed JJ cord-006856-b1w25ob5 1820 13 chimerism chimerism NN cord-006856-b1w25ob5 1820 14 and and CC cord-006856-b1w25ob5 1820 15 tolerance tolerance NN cord-006856-b1w25ob5 1820 16 . . . cord-006856-b1w25ob5 1821 1 For for IN cord-006856-b1w25ob5 1821 2 increased increase VBN cord-006856-b1w25ob5 1821 3 clinical clinical JJ cord-006856-b1w25ob5 1821 4 relevance relevance NN cord-006856-b1w25ob5 1821 5 , , , cord-006856-b1w25ob5 1821 6 tolerance tolerance NN cord-006856-b1w25ob5 1821 7 models model NNS cord-006856-b1w25ob5 1821 8 should should MD cord-006856-b1w25ob5 1821 9 preferably preferably RB cord-006856-b1w25ob5 1821 10 use use VB cord-006856-b1w25ob5 1821 11 strain strain NN cord-006856-b1w25ob5 1821 12 combinations combination NNS cord-006856-b1w25ob5 1821 13 including include VBG cord-006856-b1w25ob5 1821 14 major major JJ cord-006856-b1w25ob5 1821 15 plus plus CC cord-006856-b1w25ob5 1821 16 minor minor JJ cord-006856-b1w25ob5 1821 17 mismatches mismatch NNS cord-006856-b1w25ob5 1821 18 . . . cord-006856-b1w25ob5 1822 1 P20 P20 NNP cord-006856-b1w25ob5 1822 2 Immunohistochemical Immunohistochemical NNP cord-006856-b1w25ob5 1822 3 and and CC cord-006856-b1w25ob5 1822 4 confocal confocal JJ cord-006856-b1w25ob5 1822 5 analysis analysis NN cord-006856-b1w25ob5 1822 6 of of IN cord-006856-b1w25ob5 1822 7 pancreatic pancreatic NN cord-006856-b1w25ob5 1822 8 tetranectin tetranectin NNP cord-006856-b1w25ob5 1822 9 D. D. NNP cord-006856-b1w25ob5 1822 10 Pirkebner Pirkebner NNP cord-006856-b1w25ob5 1822 11 1 1 CD cord-006856-b1w25ob5 1822 12 , , , cord-006856-b1w25ob5 1822 13 M. M. NNP cord-006856-b1w25ob5 1822 14 Hermann Hermann NNP cord-006856-b1w25ob5 1822 15 1 1 CD cord-006856-b1w25ob5 1822 16 , , , cord-006856-b1w25ob5 1822 17 A. A. NNP cord-006856-b1w25ob5 1822 18 Draxl Draxl NNP cord-006856-b1w25ob5 1822 19 1 1 CD cord-006856-b1w25ob5 1822 20 , , , cord-006856-b1w25ob5 1822 21 W. W. NNP cord-006856-b1w25ob5 1822 22 Mark Mark NNP cord-006856-b1w25ob5 1822 23 2 2 CD cord-006856-b1w25ob5 1822 24 , , , cord-006856-b1w25ob5 1822 25 R. R. NNP cord-006856-b1w25ob5 1822 26 Margreiter Margreiter NNP cord-006856-b1w25ob5 1822 27 2 2 CD cord-006856-b1w25ob5 1822 28 , , , cord-006856-b1w25ob5 1822 29 P. P. NNP cord-006856-b1w25ob5 1822 30 Hengster Hengster NNP cord-006856-b1w25ob5 1822 31 2 2 CD cord-006856-b1w25ob5 1822 32 Background Background NNP cord-006856-b1w25ob5 1822 33 . . . cord-006856-b1w25ob5 1823 1 Islet islet NN cord-006856-b1w25ob5 1823 2 transplantation transplantation NN cord-006856-b1w25ob5 1823 3 is be VBZ cord-006856-b1w25ob5 1823 4 not not RB cord-006856-b1w25ob5 1823 5 yet yet RB cord-006856-b1w25ob5 1823 6 widely widely RB cord-006856-b1w25ob5 1823 7 used use VBN cord-006856-b1w25ob5 1823 8 in in IN cord-006856-b1w25ob5 1823 9 part part NN cord-006856-b1w25ob5 1823 10 because because IN cord-006856-b1w25ob5 1823 11 of of IN cord-006856-b1w25ob5 1823 12 the the DT cord-006856-b1w25ob5 1823 13 shortage shortage NN cord-006856-b1w25ob5 1823 14 of of IN cord-006856-b1w25ob5 1823 15 human human JJ cord-006856-b1w25ob5 1823 16 islet islet NN cord-006856-b1w25ob5 1823 17 cells cell NNS cord-006856-b1w25ob5 1823 18 . . . cord-006856-b1w25ob5 1824 1 Gaining gain VBG cord-006856-b1w25ob5 1824 2 detailed detailed JJ cord-006856-b1w25ob5 1824 3 knowledge knowledge NN cord-006856-b1w25ob5 1824 4 of of IN cord-006856-b1w25ob5 1824 5 the the DT cord-006856-b1w25ob5 1824 6 physiological physiological JJ cord-006856-b1w25ob5 1824 7 basis basis NN cord-006856-b1w25ob5 1824 8 governing govern VBG cord-006856-b1w25ob5 1824 9 the the DT cord-006856-b1w25ob5 1824 10 processes process NNS cord-006856-b1w25ob5 1824 11 of of IN cord-006856-b1w25ob5 1824 12 differentiation differentiation NN cord-006856-b1w25ob5 1824 13 of of IN cord-006856-b1w25ob5 1824 14 pancreatic pancreatic JJ cord-006856-b1w25ob5 1824 15 stem stem NN cord-006856-b1w25ob5 1824 16 or or CC cord-006856-b1w25ob5 1824 17 progenitor progenitor NN cord-006856-b1w25ob5 1824 18 cells cell NNS cord-006856-b1w25ob5 1824 19 that that WDT cord-006856-b1w25ob5 1824 20 have have VBP cord-006856-b1w25ob5 1824 21 the the DT cord-006856-b1w25ob5 1824 22 capacity capacity NN cord-006856-b1w25ob5 1824 23 to to IN cord-006856-b1w25ob5 1824 24 self self NN cord-006856-b1w25ob5 1824 25 - - HYPH cord-006856-b1w25ob5 1824 26 renewal renewal NN cord-006856-b1w25ob5 1824 27 and and CC cord-006856-b1w25ob5 1824 28 to to TO cord-006856-b1w25ob5 1824 29 generate generate VB cord-006856-b1w25ob5 1824 30 differentiated differentiate VBN cord-006856-b1w25ob5 1824 31 beta beta NN cord-006856-b1w25ob5 1824 32 cells cell NNS cord-006856-b1w25ob5 1824 33 is be VBZ cord-006856-b1w25ob5 1824 34 instrumental instrumental JJ cord-006856-b1w25ob5 1824 35 for for IN cord-006856-b1w25ob5 1824 36 the the DT cord-006856-b1w25ob5 1824 37 ambitious ambitious JJ cord-006856-b1w25ob5 1824 38 goal goal NN cord-006856-b1w25ob5 1824 39 of of IN cord-006856-b1w25ob5 1824 40 engineering engineer VBG cord-006856-b1w25ob5 1824 41 new new JJ cord-006856-b1w25ob5 1824 42 pancreatic pancreatic JJ cord-006856-b1w25ob5 1824 43 islets islet NNS cord-006856-b1w25ob5 1824 44 in in IN cord-006856-b1w25ob5 1824 45 order order NN cord-006856-b1w25ob5 1824 46 to to TO cord-006856-b1w25ob5 1824 47 cure cure VB cord-006856-b1w25ob5 1824 48 type type NN cord-006856-b1w25ob5 1824 49 I -PRON- PRP cord-006856-b1w25ob5 1824 50 diabetes diabete VBZ cord-006856-b1w25ob5 1824 51 . . . cord-006856-b1w25ob5 1825 1 The the DT cord-006856-b1w25ob5 1825 2 aim aim NN cord-006856-b1w25ob5 1825 3 of of IN cord-006856-b1w25ob5 1825 4 our -PRON- PRP$ cord-006856-b1w25ob5 1825 5 study study NN cord-006856-b1w25ob5 1825 6 was be VBD cord-006856-b1w25ob5 1825 7 to to TO cord-006856-b1w25ob5 1825 8 cultivate cultivate VB cord-006856-b1w25ob5 1825 9 and and CC cord-006856-b1w25ob5 1825 10 characterize characterize VB cord-006856-b1w25ob5 1825 11 a a DT cord-006856-b1w25ob5 1825 12 pancreatic pancreatic JJ cord-006856-b1w25ob5 1825 13 cell cell NN cord-006856-b1w25ob5 1825 14 population population NN cord-006856-b1w25ob5 1825 15 expressing express VBG cord-006856-b1w25ob5 1825 16 tetranectin tetranectin NNP cord-006856-b1w25ob5 1825 17 ( ( -LRB- cord-006856-b1w25ob5 1825 18 TN TN NNP cord-006856-b1w25ob5 1825 19 ) ) -RRB- cord-006856-b1w25ob5 1825 20 . . . cord-006856-b1w25ob5 1826 1 The the DT cord-006856-b1w25ob5 1826 2 ability ability NN cord-006856-b1w25ob5 1826 3 of of IN cord-006856-b1w25ob5 1826 4 TN TN NNP cord-006856-b1w25ob5 1826 5 to to TO cord-006856-b1w25ob5 1826 6 bind bind VB cord-006856-b1w25ob5 1826 7 plasminogen plasminogen NN cord-006856-b1w25ob5 1826 8 indicates indicate VBZ cord-006856-b1w25ob5 1826 9 that that IN cord-006856-b1w25ob5 1826 10 it -PRON- PRP cord-006856-b1w25ob5 1826 11 may may MD cord-006856-b1w25ob5 1826 12 have have VB cord-006856-b1w25ob5 1826 13 a a DT cord-006856-b1w25ob5 1826 14 role role NN cord-006856-b1w25ob5 1826 15 in in IN cord-006856-b1w25ob5 1826 16 regulating regulate VBG cord-006856-b1w25ob5 1826 17 pericellular pericellular JJ cord-006856-b1w25ob5 1826 18 proteolysis proteolysis NN cord-006856-b1w25ob5 1826 19 and and CC cord-006856-b1w25ob5 1826 20 proteolytic proteolytic JJ cord-006856-b1w25ob5 1826 21 activation activation NN cord-006856-b1w25ob5 1826 22 of of IN cord-006856-b1w25ob5 1826 23 latent latent JJ cord-006856-b1w25ob5 1826 24 forms form NNS cord-006856-b1w25ob5 1826 25 of of IN cord-006856-b1w25ob5 1826 26 metalloproteinases metalloproteinase NNS cord-006856-b1w25ob5 1826 27 and and CC cord-006856-b1w25ob5 1826 28 growth growth NN cord-006856-b1w25ob5 1826 29 factors factor NNS cord-006856-b1w25ob5 1826 30 . . . cord-006856-b1w25ob5 1827 1 Methods method NNS cord-006856-b1w25ob5 1827 2 . . . cord-006856-b1w25ob5 1828 1 Islets islet NNS cord-006856-b1w25ob5 1828 2 were be VBD cord-006856-b1w25ob5 1828 3 isolated isolate VBN cord-006856-b1w25ob5 1828 4 according accord VBG cord-006856-b1w25ob5 1828 5 to to IN cord-006856-b1w25ob5 1828 6 the the DT cord-006856-b1w25ob5 1828 7 method method NN cord-006856-b1w25ob5 1828 8 of of IN cord-006856-b1w25ob5 1828 9 Ricordi Ricordi NNP cord-006856-b1w25ob5 1828 10 et et NNP cord-006856-b1w25ob5 1828 11 al al NNP cord-006856-b1w25ob5 1828 12 . . . cord-006856-b1w25ob5 1829 1 ( ( -LRB- cord-006856-b1w25ob5 1829 2 1992 1992 CD cord-006856-b1w25ob5 1829 3 ) ) -RRB- cord-006856-b1w25ob5 1829 4 using use VBG cord-006856-b1w25ob5 1829 5 a a DT cord-006856-b1w25ob5 1829 6 continuous continuous JJ cord-006856-b1w25ob5 1829 7 Ficoll Ficoll NNP cord-006856-b1w25ob5 1829 8 gradient gradient NN cord-006856-b1w25ob5 1829 9 . . . cord-006856-b1w25ob5 1830 1 Immunohistochemistry immunohistochemistry NN cord-006856-b1w25ob5 1830 2 and and CC cord-006856-b1w25ob5 1830 3 immunofluorescence immunofluorescence NN cord-006856-b1w25ob5 1830 4 were be VBD cord-006856-b1w25ob5 1830 5 performed perform VBN cord-006856-b1w25ob5 1830 6 with with IN cord-006856-b1w25ob5 1830 7 a a DT cord-006856-b1w25ob5 1830 8 monoclonal monoclonal JJ cord-006856-b1w25ob5 1830 9 antibody antibody NN cord-006856-b1w25ob5 1830 10 against against IN cord-006856-b1w25ob5 1830 11 human human JJ cord-006856-b1w25ob5 1830 12 tetranectin tetranectin NNP cord-006856-b1w25ob5 1830 13 ( ( -LRB- cord-006856-b1w25ob5 1830 14 amino amino JJ cord-006856-b1w25ob5 1830 15 acids acid NNS cord-006856-b1w25ob5 1830 16 17 17 CD cord-006856-b1w25ob5 1830 17 - - SYM cord-006856-b1w25ob5 1830 18 181 181 CD cord-006856-b1w25ob5 1830 19 of of IN cord-006856-b1w25ob5 1830 20 human human JJ cord-006856-b1w25ob5 1830 21 tetranectin tetranectin NN cord-006856-b1w25ob5 1830 22 monomer monomer NN cord-006856-b1w25ob5 1830 23 ; ; : cord-006856-b1w25ob5 1830 24 Antibodyshop Antibodyshop NNP cord-006856-b1w25ob5 1830 25 , , , cord-006856-b1w25ob5 1830 26 Grusbakken Grusbakken NNP cord-006856-b1w25ob5 1830 27 , , , cord-006856-b1w25ob5 1830 28 Denmark Denmark NNP cord-006856-b1w25ob5 1830 29 ) ) -RRB- cord-006856-b1w25ob5 1830 30 . . . cord-006856-b1w25ob5 1831 1 To to TO cord-006856-b1w25ob5 1831 2 determine determine VB cord-006856-b1w25ob5 1831 3 in in IN cord-006856-b1w25ob5 1831 4 vitro vitro FW cord-006856-b1w25ob5 1831 5 cell cell NN cord-006856-b1w25ob5 1831 6 proliferation proliferation NN cord-006856-b1w25ob5 1831 7 , , , cord-006856-b1w25ob5 1831 8 cells cell NNS cord-006856-b1w25ob5 1831 9 were be VBD cord-006856-b1w25ob5 1831 10 labeled label VBN cord-006856-b1w25ob5 1831 11 with with IN cord-006856-b1w25ob5 1831 12 BrdU BrdU NNP cord-006856-b1w25ob5 1831 13 ( ( -LRB- cord-006856-b1w25ob5 1831 14 Roche Roche NNP cord-006856-b1w25ob5 1831 15 , , , cord-006856-b1w25ob5 1831 16 Basel Basel NNP cord-006856-b1w25ob5 1831 17 , , , cord-006856-b1w25ob5 1831 18 Switzerland Switzerland NNP cord-006856-b1w25ob5 1831 19 ) ) -RRB- cord-006856-b1w25ob5 1831 20 . . . cord-006856-b1w25ob5 1832 1 Results result NNS cord-006856-b1w25ob5 1832 2 . . . cord-006856-b1w25ob5 1833 1 We -PRON- PRP cord-006856-b1w25ob5 1833 2 describe describe VBP cord-006856-b1w25ob5 1833 3 the the DT cord-006856-b1w25ob5 1833 4 localization localization NN cord-006856-b1w25ob5 1833 5 of of IN cord-006856-b1w25ob5 1833 6 TN TN NNP cord-006856-b1w25ob5 1833 7 - - HYPH cord-006856-b1w25ob5 1833 8 positive positive JJ cord-006856-b1w25ob5 1833 9 cells cell NNS cord-006856-b1w25ob5 1833 10 in in IN cord-006856-b1w25ob5 1833 11 the the DT cord-006856-b1w25ob5 1833 12 human human JJ cord-006856-b1w25ob5 1833 13 pancreas pancrea NNS cord-006856-b1w25ob5 1833 14 and and CC cord-006856-b1w25ob5 1833 15 their -PRON- PRP$ cord-006856-b1w25ob5 1833 16 growth growth NN cord-006856-b1w25ob5 1833 17 in in IN cord-006856-b1w25ob5 1833 18 vitro vitro FW cord-006856-b1w25ob5 1833 19 . . . cord-006856-b1w25ob5 1834 1 Interestingly interestingly RB cord-006856-b1w25ob5 1834 2 , , , cord-006856-b1w25ob5 1834 3 individual individual JJ cord-006856-b1w25ob5 1834 4 positive positive JJ cord-006856-b1w25ob5 1834 5 cells cell NNS cord-006856-b1w25ob5 1834 6 are be VBP cord-006856-b1w25ob5 1834 7 present present JJ cord-006856-b1w25ob5 1834 8 within within IN cord-006856-b1w25ob5 1834 9 the the DT cord-006856-b1w25ob5 1834 10 exocrine exocrine JJ cord-006856-b1w25ob5 1834 11 acini acinus NNS cord-006856-b1w25ob5 1834 12 . . . cord-006856-b1w25ob5 1835 1 We -PRON- PRP cord-006856-b1w25ob5 1835 2 were be VBD cord-006856-b1w25ob5 1835 3 able able JJ cord-006856-b1w25ob5 1835 4 to to TO cord-006856-b1w25ob5 1835 5 isolate isolate VB cord-006856-b1w25ob5 1835 6 human human JJ cord-006856-b1w25ob5 1835 7 and and CC cord-006856-b1w25ob5 1835 8 murine murine JJ cord-006856-b1w25ob5 1835 9 islets islet NNS cord-006856-b1w25ob5 1835 10 and and CC cord-006856-b1w25ob5 1835 11 cultivate cultivate VB cord-006856-b1w25ob5 1835 12 these these DT cord-006856-b1w25ob5 1835 13 tetranectin tetranectin JJ cord-006856-b1w25ob5 1835 14 - - HYPH cord-006856-b1w25ob5 1835 15 positive positive JJ cord-006856-b1w25ob5 1835 16 cells cell NNS cord-006856-b1w25ob5 1835 17 under under IN cord-006856-b1w25ob5 1835 18 adherent adherent NN cord-006856-b1w25ob5 1835 19 and and CC cord-006856-b1w25ob5 1835 20 nonadherent nonadherent NN cord-006856-b1w25ob5 1835 21 conditions condition NNS cord-006856-b1w25ob5 1835 22 as as IN cord-006856-b1w25ob5 1835 23 shown show VBN cord-006856-b1w25ob5 1835 24 by by IN cord-006856-b1w25ob5 1835 25 immunohistochemistry immunohistochemistry NN cord-006856-b1w25ob5 1835 26 and and CC cord-006856-b1w25ob5 1835 27 confocal confocal JJ cord-006856-b1w25ob5 1835 28 immunofluorescence immunofluorescence NN cord-006856-b1w25ob5 1835 29 . . . cord-006856-b1w25ob5 1836 1 The the DT cord-006856-b1w25ob5 1836 2 possibility possibility NN cord-006856-b1w25ob5 1836 3 to to IN cord-006856-b1w25ob5 1836 4 culture culture NN cord-006856-b1w25ob5 1836 5 these these DT cord-006856-b1w25ob5 1836 6 cells cell NNS cord-006856-b1w25ob5 1836 7 is be VBZ cord-006856-b1w25ob5 1836 8 a a DT cord-006856-b1w25ob5 1836 9 first first JJ cord-006856-b1w25ob5 1836 10 step step NN cord-006856-b1w25ob5 1836 11 towards towards IN cord-006856-b1w25ob5 1836 12 their -PRON- PRP$ cord-006856-b1w25ob5 1836 13 better well JJR cord-006856-b1w25ob5 1836 14 characterisation characterisation NN cord-006856-b1w25ob5 1836 15 . . . cord-006856-b1w25ob5 1837 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1837 2 . . . cord-006856-b1w25ob5 1838 1 Together together RB cord-006856-b1w25ob5 1838 2 with with IN cord-006856-b1w25ob5 1838 3 its -PRON- PRP$ cord-006856-b1w25ob5 1838 4 above above RB cord-006856-b1w25ob5 1838 5 mentioned mention VBN cord-006856-b1w25ob5 1838 6 ability ability NN cord-006856-b1w25ob5 1838 7 to to TO cord-006856-b1w25ob5 1838 8 bind bind VB cord-006856-b1w25ob5 1838 9 plasminogen plasminogen NN cord-006856-b1w25ob5 1838 10 - - HYPH cord-006856-b1w25ob5 1838 11 like like JJ cord-006856-b1w25ob5 1838 12 hepatocyte hepatocyte NN cord-006856-b1w25ob5 1838 13 growth growth NN cord-006856-b1w25ob5 1838 14 factor factor NN cord-006856-b1w25ob5 1838 15 and and CC cord-006856-b1w25ob5 1838 16 tissuetype tissuetype NN cord-006856-b1w25ob5 1838 17 activator activator NN cord-006856-b1w25ob5 1838 18 , , , cord-006856-b1w25ob5 1838 19 TN TN NNP cord-006856-b1w25ob5 1838 20 may may MD cord-006856-b1w25ob5 1838 21 thereby thereby RB cord-006856-b1w25ob5 1838 22 play play VB cord-006856-b1w25ob5 1838 23 an an DT cord-006856-b1w25ob5 1838 24 important important JJ cord-006856-b1w25ob5 1838 25 role role NN cord-006856-b1w25ob5 1838 26 in in IN cord-006856-b1w25ob5 1838 27 the the DT cord-006856-b1w25ob5 1838 28 survival survival NN cord-006856-b1w25ob5 1838 29 of of IN cord-006856-b1w25ob5 1838 30 islets islet NNS cord-006856-b1w25ob5 1838 31 after after IN cord-006856-b1w25ob5 1838 32 islet islet NN cord-006856-b1w25ob5 1838 33 transplantation transplantation NN cord-006856-b1w25ob5 1838 34 . . . cord-006856-b1w25ob5 1839 1 As as IN cord-006856-b1w25ob5 1839 2 we -PRON- PRP cord-006856-b1w25ob5 1839 3 could could MD cord-006856-b1w25ob5 1839 4 show show VB cord-006856-b1w25ob5 1839 5 , , , cord-006856-b1w25ob5 1839 6 TN TN NNP cord-006856-b1w25ob5 1839 7 positive positive JJ cord-006856-b1w25ob5 1839 8 cells cell NNS cord-006856-b1w25ob5 1839 9 can can MD cord-006856-b1w25ob5 1839 10 be be VB cord-006856-b1w25ob5 1839 11 isolated isolate VBN cord-006856-b1w25ob5 1839 12 and and CC cord-006856-b1w25ob5 1839 13 maintained maintain VBN cord-006856-b1w25ob5 1839 14 in in IN cord-006856-b1w25ob5 1839 15 culture culture NN cord-006856-b1w25ob5 1839 16 after after IN cord-006856-b1w25ob5 1839 17 human human JJ cord-006856-b1w25ob5 1839 18 islet islet NN cord-006856-b1w25ob5 1839 19 isolation isolation NN cord-006856-b1w25ob5 1839 20 , , , cord-006856-b1w25ob5 1839 21 thereby thereby RB cord-006856-b1w25ob5 1839 22 providing provide VBG cord-006856-b1w25ob5 1839 23 the the DT cord-006856-b1w25ob5 1839 24 possibility possibility NN cord-006856-b1w25ob5 1839 25 to to TO cord-006856-b1w25ob5 1839 26 further further RB cord-006856-b1w25ob5 1839 27 clarify clarify VB cord-006856-b1w25ob5 1839 28 their -PRON- PRP$ cord-006856-b1w25ob5 1839 29 role role NN cord-006856-b1w25ob5 1839 30 and and CC cord-006856-b1w25ob5 1839 31 function function VB cord-006856-b1w25ob5 1839 32 in in IN cord-006856-b1w25ob5 1839 33 vivo vivo NN cord-006856-b1w25ob5 1839 34 as as RB cord-006856-b1w25ob5 1839 35 well well RB cord-006856-b1w25ob5 1839 36 as as IN cord-006856-b1w25ob5 1839 37 in in IN cord-006856-b1w25ob5 1839 38 the the DT cord-006856-b1w25ob5 1839 39 course course NN cord-006856-b1w25ob5 1839 40 of of IN cord-006856-b1w25ob5 1839 41 islet islet NN cord-006856-b1w25ob5 1839 42 transplantation transplantation NN cord-006856-b1w25ob5 1839 43 . . . cord-006856-b1w25ob5 1840 1 P21 P21 NNP cord-006856-b1w25ob5 1840 2 FTY720 FTY720 NNP cord-006856-b1w25ob5 1840 3 interferes interfere VBZ cord-006856-b1w25ob5 1840 4 with with IN cord-006856-b1w25ob5 1840 5 effector effector NN cord-006856-b1w25ob5 1840 6 functions function NNS cord-006856-b1w25ob5 1840 7 and and CC cord-006856-b1w25ob5 1840 8 downregulates downregulate VBZ cord-006856-b1w25ob5 1840 9 protein protein JJ cord-006856-b1w25ob5 1840 10 expression expression NN cord-006856-b1w25ob5 1840 11 of of IN cord-006856-b1w25ob5 1840 12 S1P1 S1P1 NNP cord-006856-b1w25ob5 1840 13 and and CC cord-006856-b1w25ob5 1840 14 S1P4 S1P4 NNP cord-006856-b1w25ob5 1840 15 in in IN cord-006856-b1w25ob5 1840 16 human human JJ cord-006856-b1w25ob5 1840 17 dendritic dendritic JJ cord-006856-b1w25ob5 1840 18 cells cell NNS cord-006856-b1w25ob5 1840 19 tures ture NNS cord-006856-b1w25ob5 1840 20 with with IN cord-006856-b1w25ob5 1840 21 FTY720 FTY720 NNP cord-006856-b1w25ob5 1840 22 / / SYM cord-006856-b1w25ob5 1840 23 FTY720-P FTY720-P NNP cord-006856-b1w25ob5 1840 24 - - HYPH cord-006856-b1w25ob5 1840 25 treated treat VBN cord-006856-b1w25ob5 1840 26 DC DC NNP cord-006856-b1w25ob5 1840 27 illustrated illustrate VBD cord-006856-b1w25ob5 1840 28 a a DT cord-006856-b1w25ob5 1840 29 cytokine cytokine NN cord-006856-b1w25ob5 1840 30 production production NN cord-006856-b1w25ob5 1840 31 profile profile NN cord-006856-b1w25ob5 1840 32 with with IN cord-006856-b1w25ob5 1840 33 a a DT cord-006856-b1w25ob5 1840 34 lower low JJR cord-006856-b1w25ob5 1840 35 IFN- IFN- NNP cord-006856-b1w25ob5 1840 36 ? ? . cord-006856-b1w25ob5 1840 37 ( ( -LRB- cord-006856-b1w25ob5 1840 38 22 22 CD cord-006856-b1w25ob5 1840 39 % % NN cord-006856-b1w25ob5 1840 40 vs. vs. IN cord-006856-b1w25ob5 1840 41 25 25 CD cord-006856-b1w25ob5 1840 42 % % NN cord-006856-b1w25ob5 1840 43 relative relative JJ cord-006856-b1w25ob5 1840 44 reduction reduction NN cord-006856-b1w25ob5 1840 45 ) ) -RRB- cord-006856-b1w25ob5 1840 46 and and CC cord-006856-b1w25ob5 1840 47 a a DT cord-006856-b1w25ob5 1840 48 higher high JJR cord-006856-b1w25ob5 1840 49 IL-4 IL-4 NNP cord-006856-b1w25ob5 1840 50 ( ( -LRB- cord-006856-b1w25ob5 1840 51 64 64 CD cord-006856-b1w25ob5 1840 52 % % NN cord-006856-b1w25ob5 1840 53 vs. vs. IN cord-006856-b1w25ob5 1840 54 92 92 CD cord-006856-b1w25ob5 1840 55 % % NN cord-006856-b1w25ob5 1840 56 relative relative JJ cord-006856-b1w25ob5 1840 57 increase increase NN cord-006856-b1w25ob5 1840 58 ) ) -RRB- cord-006856-b1w25ob5 1840 59 , , , cord-006856-b1w25ob5 1840 60 indicating indicate VBG cord-006856-b1w25ob5 1840 61 a a DT cord-006856-b1w25ob5 1840 62 shift shift NN cord-006856-b1w25ob5 1840 63 from from IN cord-006856-b1w25ob5 1840 64 Th1 th1 NN cord-006856-b1w25ob5 1840 65 toward toward IN cord-006856-b1w25ob5 1840 66 Th2 th2 CD cord-006856-b1w25ob5 1840 67 differentiation differentiation NN cord-006856-b1w25ob5 1840 68 as as IN cord-006856-b1w25ob5 1840 69 previously previously RB cord-006856-b1w25ob5 1840 70 evinced evince VBN cord-006856-b1w25ob5 1840 71 for for IN cord-006856-b1w25ob5 1840 72 S1P. S1P. NNP cord-006856-b1w25ob5 1840 73 DC DC NNP cord-006856-b1w25ob5 1840 74 yields yield NNS cord-006856-b1w25ob5 1840 75 , , , cord-006856-b1w25ob5 1840 76 phenotypic phenotypic JJ cord-006856-b1w25ob5 1840 77 differentiation differentiation NN cord-006856-b1w25ob5 1840 78 into into IN cord-006856-b1w25ob5 1840 79 iDC iDC NNP cord-006856-b1w25ob5 1840 80 and and CC cord-006856-b1w25ob5 1840 81 mDC mDC NNP cord-006856-b1w25ob5 1840 82 ( ( -LRB- cord-006856-b1w25ob5 1840 83 besides besides IN cord-006856-b1w25ob5 1840 84 a a DT cord-006856-b1w25ob5 1840 85 minor minor JJ cord-006856-b1w25ob5 1840 86 reduction reduction NN cord-006856-b1w25ob5 1840 87 in in IN cord-006856-b1w25ob5 1840 88 CD18 CD18 NNP cord-006856-b1w25ob5 1840 89 surface surface NN cord-006856-b1w25ob5 1840 90 expression expression NN cord-006856-b1w25ob5 1840 91 ) ) -RRB- cord-006856-b1w25ob5 1840 92 , , , cord-006856-b1w25ob5 1840 93 as as RB cord-006856-b1w25ob5 1840 94 well well RB cord-006856-b1w25ob5 1840 95 as as IN cord-006856-b1w25ob5 1840 96 the the DT cord-006856-b1w25ob5 1840 97 investigated investigate VBN cord-006856-b1w25ob5 1840 98 mechanisms mechanism NNS cord-006856-b1w25ob5 1840 99 of of IN cord-006856-b1w25ob5 1840 100 iDC idc JJ cord-006856-b1w25ob5 1840 101 antigen antigen NN cord-006856-b1w25ob5 1840 102 uptake uptake NN cord-006856-b1w25ob5 1840 103 ( ( -LRB- cord-006856-b1w25ob5 1840 104 bacterial bacterial JJ cord-006856-b1w25ob5 1840 105 phagocytosis phagocytosis NN cord-006856-b1w25ob5 1840 106 , , , cord-006856-b1w25ob5 1840 107 mannose mannose NN cord-006856-b1w25ob5 1840 108 receptor receptor NN cord-006856-b1w25ob5 1840 109 - - HYPH cord-006856-b1w25ob5 1840 110 mediated mediate VBN cord-006856-b1w25ob5 1840 111 , , , cord-006856-b1w25ob5 1840 112 and and CC cord-006856-b1w25ob5 1840 113 fluid fluid JJ cord-006856-b1w25ob5 1840 114 - - HYPH cord-006856-b1w25ob5 1840 115 phase phase NN cord-006856-b1w25ob5 1840 116 endocytosis endocytosis NN cord-006856-b1w25ob5 1840 117 ) ) -RRB- cord-006856-b1w25ob5 1840 118 , , , cord-006856-b1w25ob5 1840 119 were be VBD cord-006856-b1w25ob5 1840 120 not not RB cord-006856-b1w25ob5 1840 121 affected affect VBN cord-006856-b1w25ob5 1840 122 at at IN cord-006856-b1w25ob5 1840 123 therapeutically therapeutically RB cord-006856-b1w25ob5 1840 124 relevant relevant JJ cord-006856-b1w25ob5 1840 125 concentrations concentration NNS cord-006856-b1w25ob5 1840 126 . . . cord-006856-b1w25ob5 1841 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1841 2 . . . cord-006856-b1w25ob5 1842 1 We -PRON- PRP cord-006856-b1w25ob5 1842 2 conclude conclude VBP cord-006856-b1w25ob5 1842 3 that that IN cord-006856-b1w25ob5 1842 4 treatment treatment NN cord-006856-b1w25ob5 1842 5 of of IN cord-006856-b1w25ob5 1842 6 human human JJ cord-006856-b1w25ob5 1842 7 DC DC NNP cord-006856-b1w25ob5 1842 8 with with IN cord-006856-b1w25ob5 1842 9 FTY720 FTY720 NNP cord-006856-b1w25ob5 1842 10 and and CC cord-006856-b1w25ob5 1842 11 FTY720-P FTY720-P NNP cord-006856-b1w25ob5 1842 12 interferes interfere VBZ cord-006856-b1w25ob5 1842 13 with with IN cord-006856-b1w25ob5 1842 14 DC DC NNP cord-006856-b1w25ob5 1842 15 effector effector NN cord-006856-b1w25ob5 1842 16 functions function NNS cord-006856-b1w25ob5 1842 17 that that WDT cord-006856-b1w25ob5 1842 18 are be VBP cord-006856-b1w25ob5 1842 19 essential essential JJ cord-006856-b1w25ob5 1842 20 for for IN cord-006856-b1w25ob5 1842 21 DC DC NNP cord-006856-b1w25ob5 1842 22 to to TO cord-006856-b1w25ob5 1842 23 serve serve VB cord-006856-b1w25ob5 1842 24 their -PRON- PRP$ cord-006856-b1w25ob5 1842 25 pivotal pivotal JJ cord-006856-b1w25ob5 1842 26 duty duty NN cord-006856-b1w25ob5 1842 27 as as IN cord-006856-b1w25ob5 1842 28 professional professional JJ cord-006856-b1w25ob5 1842 29 antigen antigen NN cord-006856-b1w25ob5 1842 30 - - HYPH cord-006856-b1w25ob5 1842 31 presenting present VBG cord-006856-b1w25ob5 1842 32 cells cell NNS cord-006856-b1w25ob5 1842 33 and and CC cord-006856-b1w25ob5 1842 34 that that IN cord-006856-b1w25ob5 1842 35 DC DC NNP cord-006856-b1w25ob5 1842 36 can can MD cord-006856-b1w25ob5 1842 37 therefore therefore RB cord-006856-b1w25ob5 1842 38 be be VB cord-006856-b1w25ob5 1842 39 added add VBN cord-006856-b1w25ob5 1842 40 to to IN cord-006856-b1w25ob5 1842 41 the the DT cord-006856-b1w25ob5 1842 42 potential potential JJ cord-006856-b1w25ob5 1842 43 list list NN cord-006856-b1w25ob5 1842 44 of of IN cord-006856-b1w25ob5 1842 45 target target NN cord-006856-b1w25ob5 1842 46 cells cell NNS cord-006856-b1w25ob5 1842 47 of of IN cord-006856-b1w25ob5 1842 48 FTY720 FTY720 NNP cord-006856-b1w25ob5 1842 49 . . . cord-006856-b1w25ob5 1843 1 Impairment impairment NN cord-006856-b1w25ob5 1843 2 of of IN cord-006856-b1w25ob5 1843 3 DC DC NNP cord-006856-b1w25ob5 1843 4 migration migration NN cord-006856-b1w25ob5 1843 5 and and CC cord-006856-b1w25ob5 1843 6 Th1-priming Th1-priming NNP cord-006856-b1w25ob5 1843 7 capacity capacity NN cord-006856-b1w25ob5 1843 8 due due IN cord-006856-b1w25ob5 1843 9 to to IN cord-006856-b1w25ob5 1843 10 downmodulation downmodulation NN cord-006856-b1w25ob5 1843 11 of of IN cord-006856-b1w25ob5 1843 12 DC DC NNP cord-006856-b1w25ob5 1843 13 - - HYPH cord-006856-b1w25ob5 1843 14 expressed express VBN cord-006856-b1w25ob5 1843 15 S1P s1p NN cord-006856-b1w25ob5 1843 16 1 1 CD cord-006856-b1w25ob5 1843 17 and and CC cord-006856-b1w25ob5 1843 18 S1P s1p NN cord-006856-b1w25ob5 1843 19 4 4 CD cord-006856-b1w25ob5 1843 20 might may MD cord-006856-b1w25ob5 1843 21 represent represent VB cord-006856-b1w25ob5 1843 22 a a DT cord-006856-b1w25ob5 1843 23 new new JJ cord-006856-b1w25ob5 1843 24 aspect aspect NN cord-006856-b1w25ob5 1843 25 in in IN cord-006856-b1w25ob5 1843 26 the the DT cord-006856-b1w25ob5 1843 27 overall overall JJ cord-006856-b1w25ob5 1843 28 mechanism mechanism NN cord-006856-b1w25ob5 1843 29 of of IN cord-006856-b1w25ob5 1843 30 action action NN cord-006856-b1w25ob5 1843 31 and and CC cord-006856-b1w25ob5 1843 32 hence hence RB cord-006856-b1w25ob5 1843 33 contribute contribute VBP cord-006856-b1w25ob5 1843 34 , , , cord-006856-b1w25ob5 1843 35 in in IN cord-006856-b1w25ob5 1843 36 part part NN cord-006856-b1w25ob5 1843 37 , , , cord-006856-b1w25ob5 1843 38 to to IN cord-006856-b1w25ob5 1843 39 FTY720-mediated fty720-mediated JJ cord-006856-b1w25ob5 1843 40 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1843 41 . . . cord-006856-b1w25ob5 1844 1 The the DT cord-006856-b1w25ob5 1844 2 IBAL IBAL NNP cord-006856-b1w25ob5 1844 3 - - HYPH cord-006856-b1w25ob5 1844 4 Fresenius Fresenius NNP cord-006856-b1w25ob5 1844 5 : : : cord-006856-b1w25ob5 1844 6 bioartificial bioartificial JJ cord-006856-b1w25ob5 1844 7 liver liver NN cord-006856-b1w25ob5 1844 8 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 1844 9 ( ( -LRB- cord-006856-b1w25ob5 1844 10 IBAL IBAL NNP cord-006856-b1w25ob5 1844 11 ) ) -RRB- cord-006856-b1w25ob5 1844 12 utilizing utilize VBG cord-006856-b1w25ob5 1844 13 Fresenius Fresenius NNP cord-006856-b1w25ob5 1844 14 standalone standalone NN cord-006856-b1w25ob5 1844 15 , , , cord-006856-b1w25ob5 1844 16 rotating rotate VBG cord-006856-b1w25ob5 1844 17 bioreactor bioreactor NN cord-006856-b1w25ob5 1844 18 M. M. NNP cord-006856-b1w25ob5 1844 19 Wurm Wurm NNP cord-006856-b1w25ob5 1844 20 , , , cord-006856-b1w25ob5 1844 21 V. V. NNP cord-006856-b1w25ob5 1844 22 Lubei Lubei NNP cord-006856-b1w25ob5 1844 23 , , , cord-006856-b1w25ob5 1844 24 P. P. NNP cord-006856-b1w25ob5 1844 25 Hengster Hengster NNP cord-006856-b1w25ob5 1845 1 In in IN cord-006856-b1w25ob5 1845 2 order order NN cord-006856-b1w25ob5 1845 3 to to TO cord-006856-b1w25ob5 1845 4 establish establish VB cord-006856-b1w25ob5 1845 5 a a DT cord-006856-b1w25ob5 1845 6 suitable suitable JJ cord-006856-b1w25ob5 1845 7 environment environment NN cord-006856-b1w25ob5 1845 8 for for IN cord-006856-b1w25ob5 1845 9 cultivation cultivation NN cord-006856-b1w25ob5 1845 10 of of IN cord-006856-b1w25ob5 1845 11 hepatocytes hepatocyte NNS cord-006856-b1w25ob5 1845 12 serving serve VBG cord-006856-b1w25ob5 1845 13 as as IN cord-006856-b1w25ob5 1845 14 bioartificial bioartificial JJ cord-006856-b1w25ob5 1845 15 liver liver NN cord-006856-b1w25ob5 1845 16 ( ( -LRB- cord-006856-b1w25ob5 1845 17 BAL BAL NNP cord-006856-b1w25ob5 1845 18 ) ) -RRB- cord-006856-b1w25ob5 1845 19 , , , cord-006856-b1w25ob5 1845 20 we -PRON- PRP cord-006856-b1w25ob5 1845 21 were be VBD cord-006856-b1w25ob5 1845 22 testing test VBG cord-006856-b1w25ob5 1845 23 and and CC cord-006856-b1w25ob5 1845 24 further further RB cord-006856-b1w25ob5 1845 25 developing develop VBG cord-006856-b1w25ob5 1845 26 Fresenius Fresenius NNP cord-006856-b1w25ob5 1845 27 standalone standalone NN cord-006856-b1w25ob5 1845 28 , , , cord-006856-b1w25ob5 1845 29 rotating rotate VBG cord-006856-b1w25ob5 1845 30 bioreactor bioreactor NN cord-006856-b1w25ob5 1845 31 . . . cord-006856-b1w25ob5 1846 1 To to TO cord-006856-b1w25ob5 1846 2 create create VB cord-006856-b1w25ob5 1846 3 optimal optimal JJ cord-006856-b1w25ob5 1846 4 conditions condition NNS cord-006856-b1w25ob5 1846 5 for for IN cord-006856-b1w25ob5 1846 6 cultivation cultivation NN cord-006856-b1w25ob5 1846 7 of of IN cord-006856-b1w25ob5 1846 8 hepatocytes hepatocyte NNS cord-006856-b1w25ob5 1846 9 , , , cord-006856-b1w25ob5 1846 10 a a DT cord-006856-b1w25ob5 1846 11 special special JJ cord-006856-b1w25ob5 1846 12 environment environment NN cord-006856-b1w25ob5 1846 13 of of IN cord-006856-b1w25ob5 1846 14 nearly nearly RB cord-006856-b1w25ob5 1846 15 gravity gravity NN cord-006856-b1w25ob5 1846 16 - - HYPH cord-006856-b1w25ob5 1846 17 free free JJ cord-006856-b1w25ob5 1846 18 , , , cord-006856-b1w25ob5 1846 19 low low JJ cord-006856-b1w25ob5 1846 20 shear shear NN cord-006856-b1w25ob5 1846 21 force force NN cord-006856-b1w25ob5 1846 22 and and CC cord-006856-b1w25ob5 1846 23 high high JJ cord-006856-b1w25ob5 1846 24 mass mass NN cord-006856-b1w25ob5 1846 25 transfer transfer NN cord-006856-b1w25ob5 1846 26 is be VBZ cord-006856-b1w25ob5 1846 27 needed need VBN cord-006856-b1w25ob5 1846 28 . . . cord-006856-b1w25ob5 1847 1 Furthermore furthermore RB cord-006856-b1w25ob5 1847 2 , , , cord-006856-b1w25ob5 1847 3 basic basic JJ cord-006856-b1w25ob5 1847 4 parameters parameter NNS cord-006856-b1w25ob5 1847 5 like like IN cord-006856-b1w25ob5 1847 6 stability stability NN cord-006856-b1w25ob5 1847 7 of of IN cord-006856-b1w25ob5 1847 8 heating heating NN cord-006856-b1w25ob5 1847 9 , , , cord-006856-b1w25ob5 1847 10 gas gas NN cord-006856-b1w25ob5 1847 11 exchange exchange NN cord-006856-b1w25ob5 1847 12 , , , cord-006856-b1w25ob5 1847 13 and and CC cord-006856-b1w25ob5 1847 14 sufficiency sufficiency NN cord-006856-b1w25ob5 1847 15 of of IN cord-006856-b1w25ob5 1847 16 nutrition nutrition NN cord-006856-b1w25ob5 1847 17 have have VBP cord-006856-b1w25ob5 1847 18 to to TO cord-006856-b1w25ob5 1847 19 be be VB cord-006856-b1w25ob5 1847 20 evaluated evaluate VBN cord-006856-b1w25ob5 1847 21 allowing allow VBG cord-006856-b1w25ob5 1847 22 utilization utilization NN cord-006856-b1w25ob5 1847 23 of of IN cord-006856-b1w25ob5 1847 24 various various JJ cord-006856-b1w25ob5 1847 25 breeding breeding NN cord-006856-b1w25ob5 1847 26 chambers chamber NNS cord-006856-b1w25ob5 1847 27 . . . cord-006856-b1w25ob5 1848 1 In in IN cord-006856-b1w25ob5 1848 2 summary summary NN cord-006856-b1w25ob5 1848 3 , , , cord-006856-b1w25ob5 1848 4 we -PRON- PRP cord-006856-b1w25ob5 1848 5 have have VBP cord-006856-b1w25ob5 1848 6 established establish VBN cord-006856-b1w25ob5 1848 7 a a DT cord-006856-b1w25ob5 1848 8 standalone standalone JJ cord-006856-b1w25ob5 1848 9 bioreactor bioreactor NN cord-006856-b1w25ob5 1848 10 capable capable JJ cord-006856-b1w25ob5 1848 11 of of IN cord-006856-b1w25ob5 1848 12 quick quick JJ cord-006856-b1w25ob5 1848 13 mass mass NN cord-006856-b1w25ob5 1848 14 transfer transfer NN cord-006856-b1w25ob5 1848 15 between between IN cord-006856-b1w25ob5 1848 16 small small JJ cord-006856-b1w25ob5 1848 17 and and CC cord-006856-b1w25ob5 1848 18 big big JJ cord-006856-b1w25ob5 1848 19 chambers chamber NNS cord-006856-b1w25ob5 1848 20 and and CC cord-006856-b1w25ob5 1848 21 external external JJ cord-006856-b1w25ob5 1848 22 media medium NNS cord-006856-b1w25ob5 1848 23 supply supply NN cord-006856-b1w25ob5 1848 24 , , , cord-006856-b1w25ob5 1848 25 in in IN cord-006856-b1w25ob5 1848 26 nearly nearly RB cord-006856-b1w25ob5 1848 27 gravity gravity NN cord-006856-b1w25ob5 1848 28 - - HYPH cord-006856-b1w25ob5 1848 29 free free JJ cord-006856-b1w25ob5 1848 30 environment environment NN cord-006856-b1w25ob5 1848 31 minimizing minimize VBG cord-006856-b1w25ob5 1848 32 shear shear NN cord-006856-b1w25ob5 1848 33 force force NN cord-006856-b1w25ob5 1848 34 thus thus RB cord-006856-b1w25ob5 1848 35 allowing allow VBG cord-006856-b1w25ob5 1848 36 for for IN cord-006856-b1w25ob5 1848 37 cultivation cultivation NN cord-006856-b1w25ob5 1848 38 of of IN cord-006856-b1w25ob5 1848 39 various various JJ cord-006856-b1w25ob5 1848 40 cell cell NN cord-006856-b1w25ob5 1848 41 types type NNS cord-006856-b1w25ob5 1848 42 . . . cord-006856-b1w25ob5 1849 1 Background background NN cord-006856-b1w25ob5 1849 2 . . . cord-006856-b1w25ob5 1850 1 Laparoscopic laparoscopic JJ cord-006856-b1w25ob5 1850 2 donor donor NN cord-006856-b1w25ob5 1850 3 nephrectomy nephrectomy NN cord-006856-b1w25ob5 1850 4 is be VBZ cord-006856-b1w25ob5 1850 5 a a DT cord-006856-b1w25ob5 1850 6 less less RBR cord-006856-b1w25ob5 1850 7 invasive invasive JJ cord-006856-b1w25ob5 1850 8 alternative alternative NN cord-006856-b1w25ob5 1850 9 to to TO cord-006856-b1w25ob5 1850 10 open open VB cord-006856-b1w25ob5 1850 11 nephrectomy nephrectomy NN cord-006856-b1w25ob5 1850 12 for for IN cord-006856-b1w25ob5 1850 13 living live VBG cord-006856-b1w25ob5 1850 14 kidney kidney NN cord-006856-b1w25ob5 1850 15 donation donation NN cord-006856-b1w25ob5 1850 16 . . . cord-006856-b1w25ob5 1851 1 This this DT cord-006856-b1w25ob5 1851 2 study study NN cord-006856-b1w25ob5 1851 3 presents present VBZ cord-006856-b1w25ob5 1851 4 the the DT cord-006856-b1w25ob5 1851 5 results result NNS cord-006856-b1w25ob5 1851 6 of of IN cord-006856-b1w25ob5 1851 7 the the DT cord-006856-b1w25ob5 1851 8 first first JJ cord-006856-b1w25ob5 1851 9 58 58 CD cord-006856-b1w25ob5 1851 10 laparoscopic laparoscopic JJ cord-006856-b1w25ob5 1851 11 donor donor NN cord-006856-b1w25ob5 1851 12 nephrectomies nephrectomy NNS cord-006856-b1w25ob5 1851 13 in in IN cord-006856-b1w25ob5 1851 14 our -PRON- PRP$ cord-006856-b1w25ob5 1851 15 center center NN cord-006856-b1w25ob5 1851 16 . . . cord-006856-b1w25ob5 1852 1 Methods method NNS cord-006856-b1w25ob5 1852 2 . . . cord-006856-b1w25ob5 1853 1 From from IN cord-006856-b1w25ob5 1853 2 June June NNP cord-006856-b1w25ob5 1853 3 2000 2000 CD cord-006856-b1w25ob5 1853 4 to to IN cord-006856-b1w25ob5 1853 5 May May NNP cord-006856-b1w25ob5 1853 6 2005 2005 CD cord-006856-b1w25ob5 1853 7 , , , cord-006856-b1w25ob5 1853 8 58 58 CD cord-006856-b1w25ob5 1853 9 patients patient NNS cord-006856-b1w25ob5 1853 10 underwent undergo VBD cord-006856-b1w25ob5 1853 11 laparoscopic laparoscopic JJ cord-006856-b1w25ob5 1853 12 donor donor NN cord-006856-b1w25ob5 1853 13 nephrectomy nephrectomy NN cord-006856-b1w25ob5 1853 14 for for IN cord-006856-b1w25ob5 1853 15 living living NN cord-006856-b1w25ob5 1853 16 - - HYPH cord-006856-b1w25ob5 1853 17 related relate VBN cord-006856-b1w25ob5 1853 18 renal renal JJ cord-006856-b1w25ob5 1853 19 transplantation transplantation NN cord-006856-b1w25ob5 1853 20 . . . cord-006856-b1w25ob5 1854 1 Patient patient JJ cord-006856-b1w25ob5 1854 2 demographic demographic JJ cord-006856-b1w25ob5 1854 3 , , , cord-006856-b1w25ob5 1854 4 intraoperative intraoperative JJ cord-006856-b1w25ob5 1854 5 , , , cord-006856-b1w25ob5 1854 6 and and CC cord-006856-b1w25ob5 1854 7 postoperative postoperative JJ cord-006856-b1w25ob5 1854 8 parameters parameter NNS cord-006856-b1w25ob5 1854 9 and and CC cord-006856-b1w25ob5 1854 10 complications complication NNS cord-006856-b1w25ob5 1854 11 , , , cord-006856-b1w25ob5 1854 12 as as RB cord-006856-b1w25ob5 1854 13 well well RB cord-006856-b1w25ob5 1854 14 as as IN cord-006856-b1w25ob5 1854 15 renal renal JJ cord-006856-b1w25ob5 1854 16 allograft allograft NN cord-006856-b1w25ob5 1854 17 outcome outcome NN cord-006856-b1w25ob5 1854 18 , , , cord-006856-b1w25ob5 1854 19 were be VBD cord-006856-b1w25ob5 1854 20 evaluated evaluate VBN cord-006856-b1w25ob5 1854 21 . . . cord-006856-b1w25ob5 1855 1 Results result NNS cord-006856-b1w25ob5 1855 2 . . . cord-006856-b1w25ob5 1856 1 58 58 CD cord-006856-b1w25ob5 1856 2 patients patient NNS cord-006856-b1w25ob5 1856 3 ( ( -LRB- cord-006856-b1w25ob5 1856 4 40 40 CD cord-006856-b1w25ob5 1856 5 female female JJ cord-006856-b1w25ob5 1856 6 and and CC cord-006856-b1w25ob5 1856 7 18 18 CD cord-006856-b1w25ob5 1856 8 male male NN cord-006856-b1w25ob5 1856 9 ) ) -RRB- cord-006856-b1w25ob5 1856 10 donated donate VBD cord-006856-b1w25ob5 1856 11 their -PRON- PRP$ cord-006856-b1w25ob5 1856 12 left left JJ cord-006856-b1w25ob5 1856 13 kidney kidney NN cord-006856-b1w25ob5 1856 14 . . . cord-006856-b1w25ob5 1857 1 The the DT cord-006856-b1w25ob5 1857 2 mean mean JJ cord-006856-b1w25ob5 1857 3 donor donor NN cord-006856-b1w25ob5 1857 4 age age NN cord-006856-b1w25ob5 1857 5 was be VBD cord-006856-b1w25ob5 1857 6 45 45 CD cord-006856-b1w25ob5 1857 7 years year NNS cord-006856-b1w25ob5 1857 8 ( ( -LRB- cord-006856-b1w25ob5 1857 9 24 24 CD cord-006856-b1w25ob5 1857 10 - - SYM cord-006856-b1w25ob5 1857 11 69 69 CD cord-006856-b1w25ob5 1857 12 years year NNS cord-006856-b1w25ob5 1857 13 ) ) -RRB- cord-006856-b1w25ob5 1857 14 . . . cord-006856-b1w25ob5 1858 1 The the DT cord-006856-b1w25ob5 1858 2 mean mean JJ cord-006856-b1w25ob5 1858 3 surgical surgical JJ cord-006856-b1w25ob5 1858 4 time time NN cord-006856-b1w25ob5 1858 5 was be VBD cord-006856-b1w25ob5 1858 6 233 233 CD cord-006856-b1w25ob5 1858 7 ± ± CD cord-006856-b1w25ob5 1858 8 54 54 CD cord-006856-b1w25ob5 1858 9 minutes minute NNS cord-006856-b1w25ob5 1858 10 . . . cord-006856-b1w25ob5 1859 1 Mean mean VB cord-006856-b1w25ob5 1859 2 warm warm JJ cord-006856-b1w25ob5 1859 3 ischemia ischemia NN cord-006856-b1w25ob5 1859 4 time time NN cord-006856-b1w25ob5 1859 5 was be VBD cord-006856-b1w25ob5 1859 6 179 179 CD cord-006856-b1w25ob5 1859 7 ± ± NNP cord-006856-b1w25ob5 1859 8 63 63 CD cord-006856-b1w25ob5 1859 9 seconds second NNS cord-006856-b1w25ob5 1859 10 . . . cord-006856-b1w25ob5 1860 1 Patients patient NNS cord-006856-b1w25ob5 1860 2 could could MD cord-006856-b1w25ob5 1860 3 be be VB cord-006856-b1w25ob5 1860 4 discharged discharge VBN cord-006856-b1w25ob5 1860 5 from from IN cord-006856-b1w25ob5 1860 6 hospital hospital NN cord-006856-b1w25ob5 1860 7 after after IN cord-006856-b1w25ob5 1860 8 a a DT cord-006856-b1w25ob5 1860 9 mean mean JJ cord-006856-b1w25ob5 1860 10 time time NN cord-006856-b1w25ob5 1860 11 of of IN cord-006856-b1w25ob5 1860 12 5.8 5.8 CD cord-006856-b1w25ob5 1860 13 ± ± CD cord-006856-b1w25ob5 1860 14 1.5 1.5 CD cord-006856-b1w25ob5 1860 15 days day NNS cord-006856-b1w25ob5 1860 16 . . . cord-006856-b1w25ob5 1861 1 In in IN cord-006856-b1w25ob5 1861 2 four four CD cord-006856-b1w25ob5 1861 3 patients patient NNS cord-006856-b1w25ob5 1861 4 ( ( -LRB- cord-006856-b1w25ob5 1861 5 6.9 6.9 CD cord-006856-b1w25ob5 1861 6 % % NN cord-006856-b1w25ob5 1861 7 ) ) -RRB- cord-006856-b1w25ob5 1861 8 conversion conversion NN cord-006856-b1w25ob5 1861 9 to to TO cord-006856-b1w25ob5 1861 10 open open JJ cord-006856-b1w25ob5 1861 11 surgery surgery NN cord-006856-b1w25ob5 1861 12 had have VBD cord-006856-b1w25ob5 1861 13 to to TO cord-006856-b1w25ob5 1861 14 be be VB cord-006856-b1w25ob5 1861 15 performed perform VBN cord-006856-b1w25ob5 1861 16 . . . cord-006856-b1w25ob5 1862 1 Reasons reason NNS cord-006856-b1w25ob5 1862 2 for for IN cord-006856-b1w25ob5 1862 3 conversions conversion NNS cord-006856-b1w25ob5 1862 4 were be VBD cord-006856-b1w25ob5 1862 5 lack lack NN cord-006856-b1w25ob5 1862 6 of of IN cord-006856-b1w25ob5 1862 7 operative operative JJ cord-006856-b1w25ob5 1862 8 progression progression NN cord-006856-b1w25ob5 1862 9 in in IN cord-006856-b1w25ob5 1862 10 two two CD cord-006856-b1w25ob5 1862 11 cases case NNS cord-006856-b1w25ob5 1862 12 , , , cord-006856-b1w25ob5 1862 13 in in IN cord-006856-b1w25ob5 1862 14 one one CD cord-006856-b1w25ob5 1862 15 case case NN cord-006856-b1w25ob5 1862 16 venous venous JJ cord-006856-b1w25ob5 1862 17 bleeding bleeding NN cord-006856-b1w25ob5 1862 18 , , , cord-006856-b1w25ob5 1862 19 and and CC cord-006856-b1w25ob5 1862 20 in in IN cord-006856-b1w25ob5 1862 21 one one CD cord-006856-b1w25ob5 1862 22 case case NN cord-006856-b1w25ob5 1862 23 lesion lesion NN cord-006856-b1w25ob5 1862 24 of of IN cord-006856-b1w25ob5 1862 25 the the DT cord-006856-b1w25ob5 1862 26 renal renal JJ cord-006856-b1w25ob5 1862 27 artery artery NN cord-006856-b1w25ob5 1862 28 . . . cord-006856-b1w25ob5 1863 1 There there EX cord-006856-b1w25ob5 1863 2 were be VBD cord-006856-b1w25ob5 1863 3 no no DT cord-006856-b1w25ob5 1863 4 reoperations reoperation NNS cord-006856-b1w25ob5 1863 5 required require VBN cord-006856-b1w25ob5 1863 6 in in IN cord-006856-b1w25ob5 1863 7 the the DT cord-006856-b1w25ob5 1863 8 donors donor NNS cord-006856-b1w25ob5 1863 9 . . . cord-006856-b1w25ob5 1864 1 In in IN cord-006856-b1w25ob5 1864 2 the the DT cord-006856-b1w25ob5 1864 3 recipients recipient NNS cord-006856-b1w25ob5 1864 4 , , , cord-006856-b1w25ob5 1864 5 3 3 CD cord-006856-b1w25ob5 1864 6 ( ( -LRB- cord-006856-b1w25ob5 1864 7 5.2 5.2 CD cord-006856-b1w25ob5 1864 8 % % NN cord-006856-b1w25ob5 1864 9 ) ) -RRB- cord-006856-b1w25ob5 1864 10 delayed delay VBN cord-006856-b1w25ob5 1864 11 graft graft NN cord-006856-b1w25ob5 1864 12 functions function NNS cord-006856-b1w25ob5 1864 13 and and CC cord-006856-b1w25ob5 1864 14 1 1 CD cord-006856-b1w25ob5 1864 15 ( ( -LRB- cord-006856-b1w25ob5 1864 16 1.7 1.7 CD cord-006856-b1w25ob5 1864 17 % % NN cord-006856-b1w25ob5 1864 18 ) ) -RRB- cord-006856-b1w25ob5 1865 1 primary primary JJ cord-006856-b1w25ob5 1865 2 nonfunction nonfunction NNP cord-006856-b1w25ob5 1865 3 were be VBD cord-006856-b1w25ob5 1865 4 observed observe VBN cord-006856-b1w25ob5 1865 5 . . . cord-006856-b1w25ob5 1866 1 Mean mean JJ cord-006856-b1w25ob5 1866 2 serum serum NN cord-006856-b1w25ob5 1866 3 creatinine creatinine NN cord-006856-b1w25ob5 1866 4 level level NN cord-006856-b1w25ob5 1866 5 in in IN cord-006856-b1w25ob5 1866 6 the the DT cord-006856-b1w25ob5 1866 7 recipients recipient NNS cord-006856-b1w25ob5 1866 8 was be VBD cord-006856-b1w25ob5 1866 9 1.3 1.3 CD cord-006856-b1w25ob5 1866 10 mg mg NNP cord-006856-b1w25ob5 1866 11 / / SYM cord-006856-b1w25ob5 1866 12 dl dl NN cord-006856-b1w25ob5 1866 13 3 3 CD cord-006856-b1w25ob5 1866 14 months month NNS cord-006856-b1w25ob5 1866 15 after after IN cord-006856-b1w25ob5 1866 16 transplantation transplantation NN cord-006856-b1w25ob5 1866 17 . . . cord-006856-b1w25ob5 1867 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1867 2 . . . cord-006856-b1w25ob5 1868 1 Laparoscopic laparoscopic JJ cord-006856-b1w25ob5 1868 2 live live JJ cord-006856-b1w25ob5 1868 3 donor donor NN cord-006856-b1w25ob5 1868 4 nephrectomy nephrectomy NN cord-006856-b1w25ob5 1868 5 is be VBZ cord-006856-b1w25ob5 1868 6 safe safe JJ cord-006856-b1w25ob5 1868 7 for for IN cord-006856-b1w25ob5 1868 8 the the DT cord-006856-b1w25ob5 1868 9 donor donor NN cord-006856-b1w25ob5 1868 10 and and CC cord-006856-b1w25ob5 1868 11 the the DT cord-006856-b1w25ob5 1868 12 transplant transplant NN cord-006856-b1w25ob5 1868 13 kidney kidney NN cord-006856-b1w25ob5 1868 14 . . . cord-006856-b1w25ob5 1869 1 We -PRON- PRP cord-006856-b1w25ob5 1869 2 believe believe VBP cord-006856-b1w25ob5 1869 3 that that IN cord-006856-b1w25ob5 1869 4 offering offer VBG cord-006856-b1w25ob5 1869 5 this this DT cord-006856-b1w25ob5 1869 6 technique technique NN cord-006856-b1w25ob5 1869 7 for for IN cord-006856-b1w25ob5 1869 8 living live VBG cord-006856-b1w25ob5 1869 9 renal renal JJ cord-006856-b1w25ob5 1869 10 donation donation NN cord-006856-b1w25ob5 1869 11 can can MD cord-006856-b1w25ob5 1869 12 safely safely RB cord-006856-b1w25ob5 1869 13 and and CC cord-006856-b1w25ob5 1869 14 effectively effectively RB cord-006856-b1w25ob5 1869 15 increase increase VB cord-006856-b1w25ob5 1869 16 the the DT cord-006856-b1w25ob5 1869 17 pool pool NN cord-006856-b1w25ob5 1869 18 of of IN cord-006856-b1w25ob5 1869 19 donor donor NN cord-006856-b1w25ob5 1869 20 organs organ NNS cord-006856-b1w25ob5 1869 21 available available JJ cord-006856-b1w25ob5 1869 22 to to IN cord-006856-b1w25ob5 1869 23 patients patient NNS cord-006856-b1w25ob5 1869 24 with with IN cord-006856-b1w25ob5 1869 25 end end NN cord-006856-b1w25ob5 1869 26 - - HYPH cord-006856-b1w25ob5 1869 27 stage stage NN cord-006856-b1w25ob5 1869 28 renal renal JJ cord-006856-b1w25ob5 1869 29 disease disease NN cord-006856-b1w25ob5 1869 30 . . . cord-006856-b1w25ob5 1870 1 Background background NN cord-006856-b1w25ob5 1870 2 . . . cord-006856-b1w25ob5 1871 1 Liver liver NN cord-006856-b1w25ob5 1871 2 transplantation transplantation NN cord-006856-b1w25ob5 1871 3 is be VBZ cord-006856-b1w25ob5 1871 4 the the DT cord-006856-b1w25ob5 1871 5 treatment treatment NN cord-006856-b1w25ob5 1871 6 of of IN cord-006856-b1w25ob5 1871 7 choice choice NN cord-006856-b1w25ob5 1871 8 for for IN cord-006856-b1w25ob5 1871 9 end end NN cord-006856-b1w25ob5 1871 10 - - HYPH cord-006856-b1w25ob5 1871 11 stage stage NN cord-006856-b1w25ob5 1871 12 acute acute JJ cord-006856-b1w25ob5 1871 13 and and CC cord-006856-b1w25ob5 1871 14 chronic chronic JJ cord-006856-b1w25ob5 1871 15 liver liver NN cord-006856-b1w25ob5 1871 16 failure failure NN cord-006856-b1w25ob5 1871 17 . . . cord-006856-b1w25ob5 1872 1 Some some DT cord-006856-b1w25ob5 1872 2 liver liver NN cord-006856-b1w25ob5 1872 3 diseases disease NNS cord-006856-b1w25ob5 1872 4 are be VBP cord-006856-b1w25ob5 1872 5 associated associate VBN cord-006856-b1w25ob5 1872 6 with with IN cord-006856-b1w25ob5 1872 7 diseases disease NNS cord-006856-b1w25ob5 1872 8 of of IN cord-006856-b1w25ob5 1872 9 the the DT cord-006856-b1w25ob5 1872 10 intestinal intestinal JJ cord-006856-b1w25ob5 1872 11 tract tract NN cord-006856-b1w25ob5 1872 12 such such JJ cord-006856-b1w25ob5 1872 13 as as IN cord-006856-b1w25ob5 1872 14 primary primary JJ cord-006856-b1w25ob5 1872 15 sclerosing sclerosing NN cord-006856-b1w25ob5 1872 16 cholangitis cholangitis NN cord-006856-b1w25ob5 1872 17 and and CC cord-006856-b1w25ob5 1872 18 inflammatory inflammatory JJ cord-006856-b1w25ob5 1872 19 bowel bowel NN cord-006856-b1w25ob5 1872 20 disease disease NN cord-006856-b1w25ob5 1872 21 . . . cord-006856-b1w25ob5 1873 1 Moreover moreover RB cord-006856-b1w25ob5 1873 2 , , , cord-006856-b1w25ob5 1873 3 post post NN cord-006856-b1w25ob5 1873 4 transplant transplant NN cord-006856-b1w25ob5 1873 5 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1873 6 agents agent NNS cord-006856-b1w25ob5 1873 7 might may MD cord-006856-b1w25ob5 1873 8 cause cause VB cord-006856-b1w25ob5 1873 9 colonic colonic JJ cord-006856-b1w25ob5 1873 10 diseases disease NNS cord-006856-b1w25ob5 1873 11 and and CC cord-006856-b1w25ob5 1873 12 there there EX cord-006856-b1w25ob5 1873 13 is be VBZ cord-006856-b1w25ob5 1873 14 an an DT cord-006856-b1w25ob5 1873 15 abundance abundance NN cord-006856-b1w25ob5 1873 16 of of IN cord-006856-b1w25ob5 1873 17 opportunistic opportunistic JJ cord-006856-b1w25ob5 1873 18 pathogens pathogen NNS cord-006856-b1w25ob5 1873 19 that that WDT cord-006856-b1w25ob5 1873 20 can can MD cord-006856-b1w25ob5 1873 21 manifest manifest VB cord-006856-b1w25ob5 1873 22 in in IN cord-006856-b1w25ob5 1873 23 the the DT cord-006856-b1w25ob5 1873 24 large large JJ cord-006856-b1w25ob5 1873 25 intestine intestine NN cord-006856-b1w25ob5 1873 26 . . . cord-006856-b1w25ob5 1874 1 Aim aim VB cord-006856-b1w25ob5 1874 2 . . . cord-006856-b1w25ob5 1875 1 We -PRON- PRP cord-006856-b1w25ob5 1875 2 retrospectively retrospectively RB cord-006856-b1w25ob5 1875 3 analyzed analyze VBD cord-006856-b1w25ob5 1875 4 the the DT cord-006856-b1w25ob5 1875 5 incidence incidence NN cord-006856-b1w25ob5 1875 6 and and CC cord-006856-b1w25ob5 1875 7 spectrum spectrum NN cord-006856-b1w25ob5 1875 8 of of IN cord-006856-b1w25ob5 1875 9 colonic colonic JJ cord-006856-b1w25ob5 1875 10 disorders disorder NNS cord-006856-b1w25ob5 1875 11 in in IN cord-006856-b1w25ob5 1875 12 a a DT cord-006856-b1w25ob5 1875 13 cohort cohort NN cord-006856-b1w25ob5 1875 14 of of IN cord-006856-b1w25ob5 1875 15 402 402 CD cord-006856-b1w25ob5 1875 16 liver liver NN cord-006856-b1w25ob5 1875 17 recipients recipient NNS cord-006856-b1w25ob5 1875 18 and and CC cord-006856-b1w25ob5 1875 19 determined determine VBD cord-006856-b1w25ob5 1875 20 the the DT cord-006856-b1w25ob5 1875 21 impact impact NN cord-006856-b1w25ob5 1875 22 of of IN cord-006856-b1w25ob5 1875 23 these these DT cord-006856-b1w25ob5 1875 24 complications complication NNS cord-006856-b1w25ob5 1875 25 on on IN cord-006856-b1w25ob5 1875 26 survival survival NN cord-006856-b1w25ob5 1875 27 . . . cord-006856-b1w25ob5 1876 1 Methods method NNS cord-006856-b1w25ob5 1876 2 . . . cord-006856-b1w25ob5 1877 1 A a DT cord-006856-b1w25ob5 1877 2 total total NN cord-006856-b1w25ob5 1877 3 of of IN cord-006856-b1w25ob5 1877 4 467 467 CD cord-006856-b1w25ob5 1877 5 consecutive consecutive JJ cord-006856-b1w25ob5 1877 6 LTs lt NNS cord-006856-b1w25ob5 1877 7 in in IN cord-006856-b1w25ob5 1877 8 402 402 CD cord-006856-b1w25ob5 1877 9 individuals individual NNS cord-006856-b1w25ob5 1877 10 were be VBD cord-006856-b1w25ob5 1877 11 performed perform VBN cord-006856-b1w25ob5 1877 12 between between IN cord-006856-b1w25ob5 1877 13 1998 1998 CD cord-006856-b1w25ob5 1877 14 and and CC cord-006856-b1w25ob5 1877 15 2001 2001 CD cord-006856-b1w25ob5 1877 16 at at IN cord-006856-b1w25ob5 1877 17 the the DT cord-006856-b1w25ob5 1877 18 Mayo Mayo NNP cord-006856-b1w25ob5 1877 19 Clinic Clinic NNP cord-006856-b1w25ob5 1877 20 , , , cord-006856-b1w25ob5 1877 21 Jacksonville Jacksonville NNP cord-006856-b1w25ob5 1877 22 , , , cord-006856-b1w25ob5 1877 23 Florida Florida NNP cord-006856-b1w25ob5 1877 24 . . . cord-006856-b1w25ob5 1878 1 Standard standard JJ cord-006856-b1w25ob5 1878 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1878 3 consisted consist VBD cord-006856-b1w25ob5 1878 4 of of IN cord-006856-b1w25ob5 1878 5 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1878 6 , , , cord-006856-b1w25ob5 1878 7 Mycophenolic Mycophenolic NNP cord-006856-b1w25ob5 1878 8 acid acid NN cord-006856-b1w25ob5 1878 9 , , , cord-006856-b1w25ob5 1878 10 and and CC cord-006856-b1w25ob5 1878 11 rapidly rapidly RB cord-006856-b1w25ob5 1878 12 tapered tapered JJ cord-006856-b1w25ob5 1878 13 steroids steroid NNS cord-006856-b1w25ob5 1878 14 . . . cord-006856-b1w25ob5 1879 1 Results result NNS cord-006856-b1w25ob5 1879 2 . . . cord-006856-b1w25ob5 1880 1 There there EX cord-006856-b1w25ob5 1880 2 were be VBD cord-006856-b1w25ob5 1880 3 29 29 CD cord-006856-b1w25ob5 1880 4 patients patient NNS cord-006856-b1w25ob5 1880 5 transplanted transplant VBN cord-006856-b1w25ob5 1880 6 for for IN cord-006856-b1w25ob5 1880 7 PSC PSC NNP cord-006856-b1w25ob5 1880 8 and and CC cord-006856-b1w25ob5 1880 9 19 19 CD cord-006856-b1w25ob5 1880 10 were be VBD cord-006856-b1w25ob5 1880 11 also also RB cord-006856-b1w25ob5 1880 12 diagnosed diagnose VBN cord-006856-b1w25ob5 1880 13 with with IN cord-006856-b1w25ob5 1880 14 inflammatory inflammatory JJ cord-006856-b1w25ob5 1880 15 bowel bowel NN cord-006856-b1w25ob5 1880 16 disease disease NN cord-006856-b1w25ob5 1880 17 ( ( -LRB- cord-006856-b1w25ob5 1880 18 ulcerative ulcerative JJ cord-006856-b1w25ob5 1880 19 colitis colitis NN cord-006856-b1w25ob5 1880 20 , , , cord-006856-b1w25ob5 1880 21 n n NN cord-006856-b1w25ob5 1880 22 = = SYM cord-006856-b1w25ob5 1880 23 16 16 CD cord-006856-b1w25ob5 1880 24 ; ; : cord-006856-b1w25ob5 1880 25 Crohn Crohn NNP cord-006856-b1w25ob5 1880 26 's 's POS cord-006856-b1w25ob5 1880 27 disease disease NN cord-006856-b1w25ob5 1880 28 , , , cord-006856-b1w25ob5 1880 29 n n NN cord-006856-b1w25ob5 1880 30 = = SYM cord-006856-b1w25ob5 1880 31 3 3 CD cord-006856-b1w25ob5 1880 32 ) ) -RRB- cord-006856-b1w25ob5 1880 33 , , , cord-006856-b1w25ob5 1880 34 with with IN cord-006856-b1w25ob5 1880 35 eight eight CD cord-006856-b1w25ob5 1880 36 having have VBG cord-006856-b1w25ob5 1880 37 undergone undergo VBN cord-006856-b1w25ob5 1880 38 colonic colonic JJ cord-006856-b1w25ob5 1880 39 resection resection NN cord-006856-b1w25ob5 1880 40 prior prior RB cord-006856-b1w25ob5 1880 41 to to IN cord-006856-b1w25ob5 1880 42 LT LT NNP cord-006856-b1w25ob5 1880 43 . . . cord-006856-b1w25ob5 1881 1 In in IN cord-006856-b1w25ob5 1881 2 four four CD cord-006856-b1w25ob5 1881 3 patients patient NNS cord-006856-b1w25ob5 1881 4 , , , cord-006856-b1w25ob5 1881 5 colitis colitis NN cord-006856-b1w25ob5 1881 6 persisted persist VBD cord-006856-b1w25ob5 1881 7 post post NN cord-006856-b1w25ob5 1881 8 transplant transplant NN cord-006856-b1w25ob5 1881 9 . . . cord-006856-b1w25ob5 1882 1 Six six CD cord-006856-b1w25ob5 1882 2 patients patient NNS cord-006856-b1w25ob5 1882 3 had have VBD cord-006856-b1w25ob5 1882 4 a a DT cord-006856-b1w25ob5 1882 5 history history NN cord-006856-b1w25ob5 1882 6 of of IN cord-006856-b1w25ob5 1882 7 colonic colonic JJ cord-006856-b1w25ob5 1882 8 resection resection NN cord-006856-b1w25ob5 1882 9 for for IN cord-006856-b1w25ob5 1882 10 malignant malignant JJ cord-006856-b1w25ob5 1882 11 ( ( -LRB- cord-006856-b1w25ob5 1882 12 n n NN cord-006856-b1w25ob5 1882 13 = = SYM cord-006856-b1w25ob5 1882 14 3 3 CD cord-006856-b1w25ob5 1882 15 ) ) -RRB- cord-006856-b1w25ob5 1882 16 or or CC cord-006856-b1w25ob5 1882 17 infectious infectious JJ cord-006856-b1w25ob5 1882 18 diseases disease NNS cord-006856-b1w25ob5 1882 19 . . . cord-006856-b1w25ob5 1883 1 Five five CD cord-006856-b1w25ob5 1883 2 patients patient NNS cord-006856-b1w25ob5 1883 3 had have VBD cord-006856-b1w25ob5 1883 4 pre pre JJ cord-006856-b1w25ob5 1883 5 - - JJ cord-006856-b1w25ob5 1883 6 transplant transplant JJ cord-006856-b1w25ob5 1883 7 endoscopic endoscopic NNS cord-006856-b1w25ob5 1883 8 polypectomy polypectomy NN cord-006856-b1w25ob5 1883 9 . . . cord-006856-b1w25ob5 1884 1 Combined combine VBN cord-006856-b1w25ob5 1884 2 colon colon NN cord-006856-b1w25ob5 1884 3 resection resection NN cord-006856-b1w25ob5 1884 4 and and CC cord-006856-b1w25ob5 1884 5 transplantation transplantation NN cord-006856-b1w25ob5 1884 6 were be VBD cord-006856-b1w25ob5 1884 7 done do VBN cord-006856-b1w25ob5 1884 8 in in IN cord-006856-b1w25ob5 1884 9 2 2 CD cord-006856-b1w25ob5 1884 10 patients patient NNS cord-006856-b1w25ob5 1884 11 ; ; : cord-006856-b1w25ob5 1884 12 one one CD cord-006856-b1w25ob5 1884 13 with with IN cord-006856-b1w25ob5 1884 14 peritonitis peritonitis NN cord-006856-b1w25ob5 1884 15 and and CC cord-006856-b1w25ob5 1884 16 multiple multiple JJ cord-006856-b1w25ob5 1884 17 colonic colonic JJ cord-006856-b1w25ob5 1884 18 perforations perforation NNS cord-006856-b1w25ob5 1884 19 during during IN cord-006856-b1w25ob5 1884 20 retransplantation retransplantation NN cord-006856-b1w25ob5 1884 21 and and CC cord-006856-b1w25ob5 1884 22 the the DT cord-006856-b1w25ob5 1884 23 other other JJ cord-006856-b1w25ob5 1884 24 for for IN cord-006856-b1w25ob5 1884 25 ischemic ischemic JJ cord-006856-b1w25ob5 1884 26 colitis colitis NN cord-006856-b1w25ob5 1884 27 leading lead VBG cord-006856-b1w25ob5 1884 28 to to IN cord-006856-b1w25ob5 1884 29 fulminant fulminant JJ cord-006856-b1w25ob5 1884 30 liver liver NN cord-006856-b1w25ob5 1884 31 failure failure NN cord-006856-b1w25ob5 1884 32 . . . cord-006856-b1w25ob5 1885 1 In in IN cord-006856-b1w25ob5 1885 2 another another DT cord-006856-b1w25ob5 1885 3 case case NN cord-006856-b1w25ob5 1885 4 a a DT cord-006856-b1w25ob5 1885 5 preexisting preexisting JJ cord-006856-b1w25ob5 1885 6 transverse transverse JJ cord-006856-b1w25ob5 1885 7 colostomy colostomy NN cord-006856-b1w25ob5 1885 8 had have VBD cord-006856-b1w25ob5 1885 9 to to TO cord-006856-b1w25ob5 1885 10 be be VB cord-006856-b1w25ob5 1885 11 reinforced reinforce VBN cord-006856-b1w25ob5 1885 12 . . . cord-006856-b1w25ob5 1886 1 There there EX cord-006856-b1w25ob5 1886 2 were be VBD cord-006856-b1w25ob5 1886 3 32 32 CD cord-006856-b1w25ob5 1886 4 cases case NNS cord-006856-b1w25ob5 1886 5 of of IN cord-006856-b1w25ob5 1886 6 Clostridium clostridium NN cord-006856-b1w25ob5 1886 7 difficile difficile NN cord-006856-b1w25ob5 1886 8 - - HYPH cord-006856-b1w25ob5 1886 9 associated associate VBN cord-006856-b1w25ob5 1886 10 enterocolitis enterocolitis NN cord-006856-b1w25ob5 1886 11 . . . cord-006856-b1w25ob5 1887 1 Nine nine CD cord-006856-b1w25ob5 1887 2 patients patient NNS cord-006856-b1w25ob5 1887 3 developed develop VBD cord-006856-b1w25ob5 1887 4 CMV CMV NNP cord-006856-b1w25ob5 1887 5 gastrointestinal gastrointestinal JJ cord-006856-b1w25ob5 1887 6 complications complication NNS cord-006856-b1w25ob5 1887 7 with with IN cord-006856-b1w25ob5 1887 8 three three CD cord-006856-b1w25ob5 1887 9 cases case NNS cord-006856-b1w25ob5 1887 10 of of IN cord-006856-b1w25ob5 1887 11 colitis colitis NN cord-006856-b1w25ob5 1887 12 , , , cord-006856-b1w25ob5 1887 13 one one CD cord-006856-b1w25ob5 1887 14 leading lead VBG cord-006856-b1w25ob5 1887 15 to to IN cord-006856-b1w25ob5 1887 16 perforation perforation NN cord-006856-b1w25ob5 1887 17 , , , cord-006856-b1w25ob5 1887 18 intra intra JJ cord-006856-b1w25ob5 1887 19 - - JJ cord-006856-b1w25ob5 1887 20 abdominal abdominal JJ cord-006856-b1w25ob5 1887 21 sepsis sepsis NN cord-006856-b1w25ob5 1887 22 and and CC cord-006856-b1w25ob5 1887 23 death death NN cord-006856-b1w25ob5 1887 24 . . . cord-006856-b1w25ob5 1888 1 Two two CD cord-006856-b1w25ob5 1888 2 patients patient NNS cord-006856-b1w25ob5 1888 3 developed develop VBD cord-006856-b1w25ob5 1888 4 sigmoid sigmoid JJ cord-006856-b1w25ob5 1888 5 diverticulitis diverticulitis NN cord-006856-b1w25ob5 1888 6 and and CC cord-006856-b1w25ob5 1888 7 one one CD cord-006856-b1w25ob5 1888 8 appendicitis appendicitis NN cord-006856-b1w25ob5 1888 9 . . . cord-006856-b1w25ob5 1889 1 Colonic colonic JJ cord-006856-b1w25ob5 1889 2 polyps polyp NNS cord-006856-b1w25ob5 1889 3 were be VBD cord-006856-b1w25ob5 1889 4 endoscopically endoscopically RB cord-006856-b1w25ob5 1889 5 removed remove VBN cord-006856-b1w25ob5 1889 6 in in IN cord-006856-b1w25ob5 1889 7 seven seven CD cord-006856-b1w25ob5 1889 8 patients patient NNS cord-006856-b1w25ob5 1889 9 and and CC cord-006856-b1w25ob5 1889 10 three three CD cord-006856-b1w25ob5 1889 11 patients patient NNS cord-006856-b1w25ob5 1889 12 were be VBD cord-006856-b1w25ob5 1889 13 diagnosed diagnose VBN cord-006856-b1w25ob5 1889 14 with with IN cord-006856-b1w25ob5 1889 15 colorectal colorectal JJ cord-006856-b1w25ob5 1889 16 cancer cancer NN cord-006856-b1w25ob5 1889 17 ( ( -LRB- cord-006856-b1w25ob5 1889 18 one one CD cord-006856-b1w25ob5 1889 19 cecal cecal JJ cord-006856-b1w25ob5 1889 20 , , , cord-006856-b1w25ob5 1889 21 two two CD cord-006856-b1w25ob5 1889 22 rectal rectal JJ cord-006856-b1w25ob5 1889 23 cancers cancer NNS cord-006856-b1w25ob5 1889 24 ) ) -RRB- cord-006856-b1w25ob5 1889 25 , , , cord-006856-b1w25ob5 1889 26 which which WDT cord-006856-b1w25ob5 1889 27 all all DT cord-006856-b1w25ob5 1889 28 were be VBD cord-006856-b1w25ob5 1889 29 surgically surgically RB cord-006856-b1w25ob5 1889 30 treated treat VBN cord-006856-b1w25ob5 1889 31 . . . cord-006856-b1w25ob5 1890 1 Chronic chronic JJ cord-006856-b1w25ob5 1890 2 unexplained unexplained JJ cord-006856-b1w25ob5 1890 3 diarrhea diarrhea NN cord-006856-b1w25ob5 1890 4 was be VBD cord-006856-b1w25ob5 1890 5 observed observe VBN cord-006856-b1w25ob5 1890 6 in in IN cord-006856-b1w25ob5 1890 7 fifteen fifteen CD cord-006856-b1w25ob5 1890 8 patients patient NNS cord-006856-b1w25ob5 1890 9 , , , cord-006856-b1w25ob5 1890 10 which which WDT cord-006856-b1w25ob5 1890 11 led lead VBD cord-006856-b1w25ob5 1890 12 to to IN cord-006856-b1w25ob5 1890 13 withdrawal withdrawal NN cord-006856-b1w25ob5 1890 14 of of IN cord-006856-b1w25ob5 1890 15 mycophenolic mycophenolic JJ cord-006856-b1w25ob5 1890 16 acid acid NN cord-006856-b1w25ob5 1890 17 . . . cord-006856-b1w25ob5 1891 1 One one CD cord-006856-b1w25ob5 1891 2 patient patient NN cord-006856-b1w25ob5 1891 3 developed develop VBD cord-006856-b1w25ob5 1891 4 a a DT cord-006856-b1w25ob5 1891 5 hemorrhage hemorrhage NN cord-006856-b1w25ob5 1891 6 of of IN cord-006856-b1w25ob5 1891 7 the the DT cord-006856-b1w25ob5 1891 8 terminal terminal JJ cord-006856-b1w25ob5 1891 9 ileum ileum NN cord-006856-b1w25ob5 1891 10 / / SYM cord-006856-b1w25ob5 1891 11 cecal cecal NN cord-006856-b1w25ob5 1891 12 region region NN cord-006856-b1w25ob5 1891 13 in in IN cord-006856-b1w25ob5 1891 14 the the DT cord-006856-b1w25ob5 1891 15 course course NN cord-006856-b1w25ob5 1891 16 of of IN cord-006856-b1w25ob5 1891 17 intra intra JJ cord-006856-b1w25ob5 1891 18 - - JJ cord-006856-b1w25ob5 1891 19 abdominal abdominal JJ cord-006856-b1w25ob5 1891 20 sepsis sepsis NN cord-006856-b1w25ob5 1891 21 and and CC cord-006856-b1w25ob5 1891 22 was be VBD cord-006856-b1w25ob5 1891 23 treated treat VBN cord-006856-b1w25ob5 1891 24 by by IN cord-006856-b1w25ob5 1891 25 endovascular endovascular JJ cord-006856-b1w25ob5 1891 26 embolization embolization NN cord-006856-b1w25ob5 1891 27 of of IN cord-006856-b1w25ob5 1891 28 the the DT cord-006856-b1w25ob5 1891 29 ileocolic ileocolic JJ cord-006856-b1w25ob5 1891 30 artery artery NN cord-006856-b1w25ob5 1891 31 . . . cord-006856-b1w25ob5 1892 1 Four four CD cord-006856-b1w25ob5 1892 2 patients patient NNS cord-006856-b1w25ob5 1892 3 had have VBD cord-006856-b1w25ob5 1892 4 ongoing ongoing JJ cord-006856-b1w25ob5 1892 5 ulcerative ulcerative JJ cord-006856-b1w25ob5 1892 6 colitis colitis NN cord-006856-b1w25ob5 1892 7 . . . cord-006856-b1w25ob5 1893 1 One one CD cord-006856-b1w25ob5 1893 2 herpetic herpetic JJ cord-006856-b1w25ob5 1893 3 rectal rectal JJ cord-006856-b1w25ob5 1893 4 ulcer ulcer NN cord-006856-b1w25ob5 1893 5 and and CC cord-006856-b1w25ob5 1893 6 two two CD cord-006856-b1w25ob5 1893 7 perianal perianal JJ cord-006856-b1w25ob5 1893 8 HSV hsv NN cord-006856-b1w25ob5 1893 9 - - HYPH cord-006856-b1w25ob5 1893 10 associated associate VBN cord-006856-b1w25ob5 1893 11 lesions lesion NNS cord-006856-b1w25ob5 1893 12 were be VBD cord-006856-b1w25ob5 1893 13 diagnosed diagnose VBN cord-006856-b1w25ob5 1893 14 . . . cord-006856-b1w25ob5 1894 1 Two two CD cord-006856-b1w25ob5 1894 2 patients patient NNS cord-006856-b1w25ob5 1894 3 developed develop VBD cord-006856-b1w25ob5 1894 4 hemorrhoids hemorrhoid NNS cord-006856-b1w25ob5 1894 5 requiring require VBG cord-006856-b1w25ob5 1894 6 surgical surgical JJ cord-006856-b1w25ob5 1894 7 interventions intervention NNS cord-006856-b1w25ob5 1894 8 , , , cord-006856-b1w25ob5 1894 9 and and CC cord-006856-b1w25ob5 1894 10 two two CD cord-006856-b1w25ob5 1894 11 patients patient NNS cord-006856-b1w25ob5 1894 12 had have VBD cord-006856-b1w25ob5 1894 13 perianal perianal JJ cord-006856-b1w25ob5 1894 14 fistulas fistula NNS cord-006856-b1w25ob5 1894 15 . . . cord-006856-b1w25ob5 1895 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1895 2 . . . cord-006856-b1w25ob5 1896 1 The the DT cord-006856-b1w25ob5 1896 2 frequency frequency NN cord-006856-b1w25ob5 1896 3 of of IN cord-006856-b1w25ob5 1896 4 colonic colonic JJ cord-006856-b1w25ob5 1896 5 disorders disorder NNS cord-006856-b1w25ob5 1896 6 in in IN cord-006856-b1w25ob5 1896 7 our -PRON- PRP$ cord-006856-b1w25ob5 1896 8 series series NN cord-006856-b1w25ob5 1896 9 was be VBD cord-006856-b1w25ob5 1896 10 higher high JJR cord-006856-b1w25ob5 1896 11 than than IN cord-006856-b1w25ob5 1896 12 expected expect VBN cord-006856-b1w25ob5 1896 13 , , , cord-006856-b1w25ob5 1896 14 with with IN cord-006856-b1w25ob5 1896 15 infections infection NNS cord-006856-b1w25ob5 1896 16 accounting account VBG cord-006856-b1w25ob5 1896 17 for for IN cord-006856-b1w25ob5 1896 18 majority majority NN cord-006856-b1w25ob5 1896 19 of of IN cord-006856-b1w25ob5 1896 20 cases case NNS cord-006856-b1w25ob5 1896 21 . . . cord-006856-b1w25ob5 1897 1 The the DT cord-006856-b1w25ob5 1897 2 high high JJ cord-006856-b1w25ob5 1897 3 incidence incidence NN cord-006856-b1w25ob5 1897 4 of of IN cord-006856-b1w25ob5 1897 5 clostridial clostridial JJ cord-006856-b1w25ob5 1897 6 colitis colitis NN cord-006856-b1w25ob5 1897 7 warrants warrant NNS cord-006856-b1w25ob5 1897 8 improvement improvement NN cord-006856-b1w25ob5 1897 9 in in IN cord-006856-b1w25ob5 1897 10 screening screening NN cord-006856-b1w25ob5 1897 11 and and CC cord-006856-b1w25ob5 1897 12 preventive preventive JJ cord-006856-b1w25ob5 1897 13 measurements measurement NNS cord-006856-b1w25ob5 1897 14 . . . cord-006856-b1w25ob5 1898 1 Screening screen VBG cord-006856-b1w25ob5 1898 2 for for IN cord-006856-b1w25ob5 1898 3 polyps polyp NNS cord-006856-b1w25ob5 1898 4 pre pre JJ cord-006856-b1w25ob5 1898 5 - - NN cord-006856-b1w25ob5 1898 6 transplant transplant NN cord-006856-b1w25ob5 1898 7 and and CC cord-006856-b1w25ob5 1898 8 annually annually RB cord-006856-b1w25ob5 1898 9 post post JJ cord-006856-b1w25ob5 1898 10 - - JJ cord-006856-b1w25ob5 1898 11 transplant transplant NN cord-006856-b1w25ob5 1898 12 might may MD cord-006856-b1w25ob5 1898 13 be be VB cord-006856-b1w25ob5 1898 14 recommended recommend VBN cord-006856-b1w25ob5 1898 15 . . . cord-006856-b1w25ob5 1899 1 Background background NN cord-006856-b1w25ob5 1899 2 . . . cord-006856-b1w25ob5 1900 1 Bartonella Bartonella NNP cord-006856-b1w25ob5 1900 2 has have VBZ cord-006856-b1w25ob5 1900 3 been be VBN cord-006856-b1w25ob5 1900 4 identified identify VBN cord-006856-b1w25ob5 1900 5 as as IN cord-006856-b1w25ob5 1900 6 causative causative JJ cord-006856-b1w25ob5 1900 7 agent agent NN cord-006856-b1w25ob5 1900 8 of of IN cord-006856-b1w25ob5 1900 9 cat cat NN cord-006856-b1w25ob5 1900 10 scratch scratch NN cord-006856-b1w25ob5 1900 11 disease disease NN cord-006856-b1w25ob5 1900 12 but but CC cord-006856-b1w25ob5 1900 13 is be VBZ cord-006856-b1w25ob5 1900 14 also also RB cord-006856-b1w25ob5 1900 15 inflicted inflict VBN cord-006856-b1w25ob5 1900 16 in in IN cord-006856-b1w25ob5 1900 17 other other JJ cord-006856-b1w25ob5 1900 18 diseases disease NNS cord-006856-b1w25ob5 1900 19 in in IN cord-006856-b1w25ob5 1900 20 the the DT cord-006856-b1w25ob5 1900 21 immunocompromised immunocompromised JJ cord-006856-b1w25ob5 1900 22 host host NN cord-006856-b1w25ob5 1900 23 . . . cord-006856-b1w25ob5 1901 1 Case case NN cord-006856-b1w25ob5 1901 2 reports report NNS cord-006856-b1w25ob5 1901 3 . . . cord-006856-b1w25ob5 1902 1 We -PRON- PRP cord-006856-b1w25ob5 1902 2 describe describe VBP cord-006856-b1w25ob5 1902 3 two two CD cord-006856-b1w25ob5 1902 4 cases case NNS cord-006856-b1w25ob5 1902 5 of of IN cord-006856-b1w25ob5 1902 6 Bartonella Bartonella NNP cord-006856-b1w25ob5 1902 7 henselae henselae NN cord-006856-b1w25ob5 1902 8 - - HYPH cord-006856-b1w25ob5 1902 9 associated associate VBN cord-006856-b1w25ob5 1902 10 diseases disease NNS cord-006856-b1w25ob5 1902 11 in in IN cord-006856-b1w25ob5 1902 12 liver liver NN cord-006856-b1w25ob5 1902 13 transplant transplant NN cord-006856-b1w25ob5 1902 14 recipients recipient NNS cord-006856-b1w25ob5 1902 15 who who WP cord-006856-b1w25ob5 1902 16 both both DT cord-006856-b1w25ob5 1902 17 had have VBD cord-006856-b1w25ob5 1902 18 contact contact NN cord-006856-b1w25ob5 1902 19 with with IN cord-006856-b1w25ob5 1902 20 cats cat NNS cord-006856-b1w25ob5 1902 21 . . . cord-006856-b1w25ob5 1903 1 The the DT cord-006856-b1w25ob5 1903 2 first first JJ cord-006856-b1w25ob5 1903 3 recipient recipient NN cord-006856-b1w25ob5 1903 4 developed develop VBD cord-006856-b1w25ob5 1903 5 localized localized JJ cord-006856-b1w25ob5 1903 6 skin skin NN cord-006856-b1w25ob5 1903 7 manifestation manifestation NN cord-006856-b1w25ob5 1903 8 of of IN cord-006856-b1w25ob5 1903 9 bacillary bacillary NNP cord-006856-b1w25ob5 1903 10 angiomatosis angiomatosis NNP cord-006856-b1w25ob5 1903 11 in in IN cord-006856-b1w25ob5 1903 12 association association NNP cord-006856-b1w25ob5 1903 13 with with IN cord-006856-b1w25ob5 1903 14 granulomatous granulomatous NNP cord-006856-b1w25ob5 1903 15 hepatitis hepatitis NNP cord-006856-b1w25ob5 1903 16 . . . cord-006856-b1w25ob5 1904 1 He -PRON- PRP cord-006856-b1w25ob5 1904 2 tested test VBD cord-006856-b1w25ob5 1904 3 positive positive JJ cord-006856-b1w25ob5 1904 4 for for IN cord-006856-b1w25ob5 1904 5 IgG igg NN cord-006856-b1w25ob5 1904 6 antibodies antibody NNS cord-006856-b1w25ob5 1904 7 against against IN cord-006856-b1w25ob5 1904 8 Bartonella Bartonella NNP cord-006856-b1w25ob5 1904 9 henselae henselae NNP cord-006856-b1w25ob5 1904 10 . . . cord-006856-b1w25ob5 1905 1 The the DT cord-006856-b1w25ob5 1905 2 second second JJ cord-006856-b1w25ob5 1905 3 patient patient NN cord-006856-b1w25ob5 1905 4 developed develop VBD cord-006856-b1w25ob5 1905 5 axillary axillary JJ cord-006856-b1w25ob5 1905 6 lymphadenopathy lymphadenopathy NN cord-006856-b1w25ob5 1905 7 , , , cord-006856-b1w25ob5 1905 8 with with IN cord-006856-b1w25ob5 1905 9 biopsy biopsy NN cord-006856-b1w25ob5 1905 10 showing show VBG cord-006856-b1w25ob5 1905 11 necrotizing necrotize VBG cord-006856-b1w25ob5 1905 12 granulomatous granulomatous JJ cord-006856-b1w25ob5 1905 13 inflammation inflammation NN cord-006856-b1w25ob5 1905 14 and and CC cord-006856-b1w25ob5 1905 15 PCR PCR NNP cord-006856-b1w25ob5 1905 16 studies study NNS cord-006856-b1w25ob5 1905 17 were be VBD cord-006856-b1w25ob5 1905 18 positive positive JJ cord-006856-b1w25ob5 1905 19 for for IN cord-006856-b1w25ob5 1905 20 Bartonella Bartonella NNP cord-006856-b1w25ob5 1905 21 henselae henselae NNP cord-006856-b1w25ob5 1905 22 DNA DNA NNP cord-006856-b1w25ob5 1905 23 . . . cord-006856-b1w25ob5 1906 1 Her -PRON- PRP$ cord-006856-b1w25ob5 1906 2 serology serology NN cord-006856-b1w25ob5 1906 3 for for IN cord-006856-b1w25ob5 1906 4 bartonellosis bartonellosis NN cord-006856-b1w25ob5 1906 5 showed show VBD cord-006856-b1w25ob5 1906 6 a a DT cord-006856-b1w25ob5 1906 7 fourfold fourfold JJ cord-006856-b1w25ob5 1906 8 rise rise NN cord-006856-b1w25ob5 1906 9 in in IN cord-006856-b1w25ob5 1906 10 antibody antibody NN cord-006856-b1w25ob5 1906 11 titers titer NNS cord-006856-b1w25ob5 1906 12 during during IN cord-006856-b1w25ob5 1906 13 her -PRON- PRP$ cord-006856-b1w25ob5 1906 14 hospitalization hospitalization NN cord-006856-b1w25ob5 1906 15 . . . cord-006856-b1w25ob5 1907 1 Both both DT cord-006856-b1w25ob5 1907 2 patients patient NNS cord-006856-b1w25ob5 1907 3 responded respond VBD cord-006856-b1w25ob5 1907 4 to to IN cord-006856-b1w25ob5 1907 5 treatment treatment NN cord-006856-b1w25ob5 1907 6 with with IN cord-006856-b1w25ob5 1907 7 Azithromycin Azithromycin NNP cord-006856-b1w25ob5 1907 8 in in IN cord-006856-b1w25ob5 1907 9 combination combination NN cord-006856-b1w25ob5 1907 10 with with IN cord-006856-b1w25ob5 1907 11 Doxycyclin Doxycyclin NNP cord-006856-b1w25ob5 1907 12 . . . cord-006856-b1w25ob5 1908 1 These these DT cord-006856-b1w25ob5 1908 2 were be VBD cord-006856-b1w25ob5 1908 3 the the DT cord-006856-b1w25ob5 1908 4 only only JJ cord-006856-b1w25ob5 1908 5 cases case NNS cord-006856-b1w25ob5 1908 6 within within IN cord-006856-b1w25ob5 1908 7 a a DT cord-006856-b1w25ob5 1908 8 series series NN cord-006856-b1w25ob5 1908 9 of of IN cord-006856-b1w25ob5 1908 10 467 467 CD cord-006856-b1w25ob5 1908 11 liver liver NN cord-006856-b1w25ob5 1908 12 transplants transplant NNS cord-006856-b1w25ob5 1908 13 in in IN cord-006856-b1w25ob5 1908 14 402 402 CD cord-006856-b1w25ob5 1908 15 patients patient NNS cord-006856-b1w25ob5 1908 16 performed perform VBN cord-006856-b1w25ob5 1908 17 during during IN cord-006856-b1w25ob5 1908 18 a a DT cord-006856-b1w25ob5 1908 19 four four CD cord-006856-b1w25ob5 1908 20 - - HYPH cord-006856-b1w25ob5 1908 21 year year NN cord-006856-b1w25ob5 1908 22 period period NN cord-006856-b1w25ob5 1908 23 . . . cord-006856-b1w25ob5 1909 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1909 2 . . . cord-006856-b1w25ob5 1910 1 Although although IN cord-006856-b1w25ob5 1910 2 bartonellosis bartonellosis NNP cord-006856-b1w25ob5 1910 3 is be VBZ cord-006856-b1w25ob5 1910 4 a a DT cord-006856-b1w25ob5 1910 5 rare rare JJ cord-006856-b1w25ob5 1910 6 infection infection NN cord-006856-b1w25ob5 1910 7 in in IN cord-006856-b1w25ob5 1910 8 LT LT NNP cord-006856-b1w25ob5 1910 9 recipients recipient NNS cord-006856-b1w25ob5 1910 10 , , , cord-006856-b1w25ob5 1910 11 one one PRP cord-006856-b1w25ob5 1910 12 should should MD cord-006856-b1w25ob5 1910 13 consider consider VB cord-006856-b1w25ob5 1910 14 this this DT cord-006856-b1w25ob5 1910 15 disease disease NN cord-006856-b1w25ob5 1910 16 in in IN cord-006856-b1w25ob5 1910 17 patients patient NNS cord-006856-b1w25ob5 1910 18 presenting present VBG cord-006856-b1w25ob5 1910 19 with with IN cord-006856-b1w25ob5 1910 20 fever fever NN cord-006856-b1w25ob5 1910 21 , , , cord-006856-b1w25ob5 1910 22 CNS cns JJ cord-006856-b1w25ob5 1910 23 symptoms symptom NNS cord-006856-b1w25ob5 1910 24 , , , cord-006856-b1w25ob5 1910 25 skin skin NN cord-006856-b1w25ob5 1910 26 lesions lesion NNS cord-006856-b1w25ob5 1910 27 , , , cord-006856-b1w25ob5 1910 28 lymphadenopathy lymphadenopathy JJ cord-006856-b1w25ob5 1910 29 or or CC cord-006856-b1w25ob5 1910 30 hepatitis hepatitis NN cord-006856-b1w25ob5 1910 31 in in IN cord-006856-b1w25ob5 1910 32 particular particular JJ cord-006856-b1w25ob5 1910 33 if if IN cord-006856-b1w25ob5 1910 34 contact contact NN cord-006856-b1w25ob5 1910 35 with with IN cord-006856-b1w25ob5 1910 36 cats cat NNS cord-006856-b1w25ob5 1910 37 is be VBZ cord-006856-b1w25ob5 1910 38 reported report VBN cord-006856-b1w25ob5 1910 39 . . . cord-006856-b1w25ob5 1911 1 Background background NN cord-006856-b1w25ob5 1911 2 . . . cord-006856-b1w25ob5 1912 1 New new JJ cord-006856-b1w25ob5 1912 2 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1912 3 protocols protocol NNS cord-006856-b1w25ob5 1912 4 and and CC cord-006856-b1w25ob5 1912 5 advanced advanced JJ cord-006856-b1w25ob5 1912 6 surgical surgical JJ cord-006856-b1w25ob5 1912 7 technique technique NN cord-006856-b1w25ob5 1912 8 resulted result VBD cord-006856-b1w25ob5 1912 9 in in IN cord-006856-b1w25ob5 1912 10 a a DT cord-006856-b1w25ob5 1912 11 major major JJ cord-006856-b1w25ob5 1912 12 improvement improvement NN cord-006856-b1w25ob5 1912 13 in in IN cord-006856-b1w25ob5 1912 14 the the DT cord-006856-b1w25ob5 1912 15 outcome outcome NN cord-006856-b1w25ob5 1912 16 of of IN cord-006856-b1w25ob5 1912 17 pancreatic pancreatic JJ cord-006856-b1w25ob5 1912 18 transplantation transplantation NN cord-006856-b1w25ob5 1912 19 . . . cord-006856-b1w25ob5 1913 1 By by IN cord-006856-b1w25ob5 1913 2 reducing reduce VBG cord-006856-b1w25ob5 1913 3 the the DT cord-006856-b1w25ob5 1913 4 incidence incidence NN cord-006856-b1w25ob5 1913 5 of of IN cord-006856-b1w25ob5 1913 6 immunological immunological JJ cord-006856-b1w25ob5 1913 7 complications complication NNS cord-006856-b1w25ob5 1913 8 using use VBG cord-006856-b1w25ob5 1913 9 intensified intensify VBN cord-006856-b1w25ob5 1913 10 immunosuppressive immunosuppressive JJ cord-006856-b1w25ob5 1913 11 protocols protocol NNS cord-006856-b1w25ob5 1913 12 , , , cord-006856-b1w25ob5 1913 13 the the DT cord-006856-b1w25ob5 1913 14 incidence incidence NN cord-006856-b1w25ob5 1913 15 of of IN cord-006856-b1w25ob5 1913 16 some some DT cord-006856-b1w25ob5 1913 17 infections infection NNS cord-006856-b1w25ob5 1913 18 , , , cord-006856-b1w25ob5 1913 19 in in IN cord-006856-b1w25ob5 1913 20 particular particular JJ cord-006856-b1w25ob5 1913 21 complicated complicated JJ cord-006856-b1w25ob5 1913 22 fungal fungal JJ cord-006856-b1w25ob5 1913 23 infections infection NNS cord-006856-b1w25ob5 1913 24 , , , cord-006856-b1w25ob5 1913 25 might may MD cord-006856-b1w25ob5 1913 26 increase increase VB cord-006856-b1w25ob5 1913 27 . . . cord-006856-b1w25ob5 1914 1 Methods method NNS cord-006856-b1w25ob5 1914 2 . . . cord-006856-b1w25ob5 1915 1 217 217 CD cord-006856-b1w25ob5 1915 2 enteric enteric NN cord-006856-b1w25ob5 1915 3 drained drained JJ cord-006856-b1w25ob5 1915 4 whole whole JJ cord-006856-b1w25ob5 1915 5 - - HYPH cord-006856-b1w25ob5 1915 6 pancreas pancreas NN cord-006856-b1w25ob5 1915 7 transplants transplant NNS cord-006856-b1w25ob5 1915 8 ( ( -LRB- cord-006856-b1w25ob5 1915 9 PTx PTx NNS cord-006856-b1w25ob5 1915 10 ) ) -RRB- cord-006856-b1w25ob5 1915 11 performed perform VBD cord-006856-b1w25ob5 1915 12 at at IN cord-006856-b1w25ob5 1915 13 the the DT cord-006856-b1w25ob5 1915 14 Innsbruck Innsbruck NNP cord-006856-b1w25ob5 1915 15 University University NNP cord-006856-b1w25ob5 1915 16 Hospital Hospital NNP cord-006856-b1w25ob5 1915 17 between between IN cord-006856-b1w25ob5 1915 18 March March NNP cord-006856-b1w25ob5 1915 19 1997 1997 CD cord-006856-b1w25ob5 1915 20 and and CC cord-006856-b1w25ob5 1915 21 October October NNP cord-006856-b1w25ob5 1915 22 2004 2004 CD cord-006856-b1w25ob5 1915 23 were be VBD cord-006856-b1w25ob5 1915 24 retrospectively retrospectively RB cord-006856-b1w25ob5 1915 25 analysed analyse VBN cord-006856-b1w25ob5 1915 26 . . . cord-006856-b1w25ob5 1916 1 Prophylactic prophylactic JJ cord-006856-b1w25ob5 1916 2 immunosuppression immunosuppression NN cord-006856-b1w25ob5 1916 3 consisted consist VBD cord-006856-b1w25ob5 1916 4 of of IN cord-006856-b1w25ob5 1916 5 ATG ATG NNP cord-006856-b1w25ob5 1916 6 induction induction NN cord-006856-b1w25ob5 1916 7 , , , cord-006856-b1w25ob5 1916 8 Tacrolimus Tacrolimus NNP cord-006856-b1w25ob5 1916 9 , , , cord-006856-b1w25ob5 1916 10 MMF MMF NNP cord-006856-b1w25ob5 1916 11 , , , cord-006856-b1w25ob5 1916 12 and and CC cord-006856-b1w25ob5 1916 13 steroids steroid NNS cord-006856-b1w25ob5 1916 14 for for IN cord-006856-b1w25ob5 1916 15 the the DT cord-006856-b1w25ob5 1916 16 majority majority NN cord-006856-b1w25ob5 1916 17 of of IN cord-006856-b1w25ob5 1916 18 cases case NNS cord-006856-b1w25ob5 1916 19 . . . cord-006856-b1w25ob5 1917 1 Perioperative perioperative JJ cord-006856-b1w25ob5 1917 2 antimicrobial antimicrobial JJ cord-006856-b1w25ob5 1917 3 prophylaxis prophylaxis NN cord-006856-b1w25ob5 1917 4 consisted consist VBN cord-006856-b1w25ob5 1917 5 of of IN cord-006856-b1w25ob5 1917 6 Amoxicillin Amoxicillin NNP cord-006856-b1w25ob5 1917 7 / / SYM cord-006856-b1w25ob5 1917 8 Clavulanic Clavulanic NNP cord-006856-b1w25ob5 1917 9 ( ( -LRB- cord-006856-b1w25ob5 1917 10 30 30 CD cord-006856-b1w25ob5 1917 11 PTx PTx NNS cord-006856-b1w25ob5 1917 12 ) ) -RRB- cord-006856-b1w25ob5 1917 13 , , , cord-006856-b1w25ob5 1917 14 Pipercillin Pipercillin NNP cord-006856-b1w25ob5 1917 15 / / SYM cord-006856-b1w25ob5 1917 16 Tazobactam Tazobactam NNP cord-006856-b1w25ob5 1917 17 ( ( -LRB- cord-006856-b1w25ob5 1917 18 157 157 CD cord-006856-b1w25ob5 1917 19 PTx PTx NNS cord-006856-b1w25ob5 1917 20 ) ) -RRB- cord-006856-b1w25ob5 1917 21 , , , cord-006856-b1w25ob5 1917 22 and and CC cord-006856-b1w25ob5 1917 23 others other NNS cord-006856-b1w25ob5 1917 24 ( ( -LRB- cord-006856-b1w25ob5 1917 25 30 30 CD cord-006856-b1w25ob5 1917 26 PTx PTx NNS cord-006856-b1w25ob5 1917 27 ) ) -RRB- cord-006856-b1w25ob5 1917 28 . . . cord-006856-b1w25ob5 1918 1 168 168 CD cord-006856-b1w25ob5 1918 2 patients patient NNS cord-006856-b1w25ob5 1918 3 additionally additionally RB cord-006856-b1w25ob5 1918 4 received receive VBD cord-006856-b1w25ob5 1918 5 fluconazole fluconazole NN cord-006856-b1w25ob5 1918 6 . . . cord-006856-b1w25ob5 1919 1 Results result NNS cord-006856-b1w25ob5 1919 2 . . . cord-006856-b1w25ob5 1920 1 Actuarial actuarial JJ cord-006856-b1w25ob5 1920 2 patient patient NN cord-006856-b1w25ob5 1920 3 , , , cord-006856-b1w25ob5 1920 4 pancreas pancreas NN cord-006856-b1w25ob5 1920 5 and and CC cord-006856-b1w25ob5 1920 6 kidney kidney NN cord-006856-b1w25ob5 1920 7 graft graft NN cord-006856-b1w25ob5 1920 8 survival survival NN cord-006856-b1w25ob5 1920 9 at at IN cord-006856-b1w25ob5 1920 10 one one CD cord-006856-b1w25ob5 1920 11 year year NN cord-006856-b1w25ob5 1920 12 were be VBD cord-006856-b1w25ob5 1920 13 96.4 96.4 CD cord-006856-b1w25ob5 1920 14 % % NN cord-006856-b1w25ob5 1920 15 , , , cord-006856-b1w25ob5 1920 16 88.5 88.5 CD cord-006856-b1w25ob5 1920 17 % % NN cord-006856-b1w25ob5 1920 18 and and CC cord-006856-b1w25ob5 1920 19 94.8 94.8 CD cord-006856-b1w25ob5 1920 20 % % NN cord-006856-b1w25ob5 1920 21 , , , cord-006856-b1w25ob5 1920 22 rejection rejection NN cord-006856-b1w25ob5 1920 23 rate rate NN cord-006856-b1w25ob5 1920 24 was be VBD cord-006856-b1w25ob5 1920 25 30 30 CD cord-006856-b1w25ob5 1920 26 % % NN cord-006856-b1w25ob5 1920 27 . . . cord-006856-b1w25ob5 1921 1 Within within IN cord-006856-b1w25ob5 1921 2 this this DT cord-006856-b1w25ob5 1921 3 series series NN cord-006856-b1w25ob5 1921 4 , , , cord-006856-b1w25ob5 1921 5 a a DT cord-006856-b1w25ob5 1921 6 total total NN cord-006856-b1w25ob5 1921 7 of of IN cord-006856-b1w25ob5 1921 8 13 13 CD cord-006856-b1w25ob5 1921 9 patients patient NNS cord-006856-b1w25ob5 1921 10 developed develop VBD cord-006856-b1w25ob5 1921 11 invasive invasive JJ cord-006856-b1w25ob5 1921 12 fungal fungal JJ cord-006856-b1w25ob5 1921 13 infections infection NNS cord-006856-b1w25ob5 1921 14 . . . cord-006856-b1w25ob5 1922 1 Of of IN cord-006856-b1w25ob5 1922 2 those those DT cord-006856-b1w25ob5 1922 3 , , , cord-006856-b1w25ob5 1922 4 four four CD cord-006856-b1w25ob5 1922 5 had have VBD cord-006856-b1w25ob5 1922 6 aspergillosis aspergillosis NN cord-006856-b1w25ob5 1922 7 , , , cord-006856-b1w25ob5 1922 8 one one CD cord-006856-b1w25ob5 1922 9 zygomycosis zygomycosis NN cord-006856-b1w25ob5 1922 10 , , , cord-006856-b1w25ob5 1922 11 and and CC cord-006856-b1w25ob5 1922 12 the the DT cord-006856-b1w25ob5 1922 13 remaining remain VBG cord-006856-b1w25ob5 1922 14 ten ten CD cord-006856-b1w25ob5 1922 15 were be VBD cord-006856-b1w25ob5 1922 16 caused cause VBN cord-006856-b1w25ob5 1922 17 by by IN cord-006856-b1w25ob5 1922 18 yeast yeast NN cord-006856-b1w25ob5 1922 19 . . . cord-006856-b1w25ob5 1923 1 Two two CD cord-006856-b1w25ob5 1923 2 patients patient NNS cord-006856-b1w25ob5 1923 3 had have VBD cord-006856-b1w25ob5 1923 4 aspergillosis aspergillosis NN cord-006856-b1w25ob5 1923 5 and and CC cord-006856-b1w25ob5 1923 6 later later JJ cord-006856-b1w25ob5 1923 7 pulmonary pulmonary JJ cord-006856-b1w25ob5 1923 8 infection infection NN cord-006856-b1w25ob5 1923 9 with with IN cord-006856-b1w25ob5 1923 10 Candida Candida NNP cord-006856-b1w25ob5 1923 11 albicans albican NNS cord-006856-b1w25ob5 1923 12 and and CC cord-006856-b1w25ob5 1923 13 Candida Candida NNP cord-006856-b1w25ob5 1923 14 glabrata glabrata NNP cord-006856-b1w25ob5 1923 15 . . . cord-006856-b1w25ob5 1924 1 The the DT cord-006856-b1w25ob5 1924 2 zygomycosis zygomycosis NN cord-006856-b1w25ob5 1924 3 was be VBD cord-006856-b1w25ob5 1924 4 the the DT cord-006856-b1w25ob5 1924 5 only only JJ cord-006856-b1w25ob5 1924 6 fungal fungal JJ cord-006856-b1w25ob5 1924 7 infection infection NN cord-006856-b1w25ob5 1924 8 that that WDT cord-006856-b1w25ob5 1924 9 was be VBD cord-006856-b1w25ob5 1924 10 diagnosed diagnose VBN cord-006856-b1w25ob5 1924 11 post post NN cord-006856-b1w25ob5 1924 12 mortem mortem NN cord-006856-b1w25ob5 1924 13 and and CC cord-006856-b1w25ob5 1924 14 this this DT cord-006856-b1w25ob5 1924 15 patient patient NN cord-006856-b1w25ob5 1924 16 had have VBD cord-006856-b1w25ob5 1924 17 received receive VBN cord-006856-b1w25ob5 1924 18 pretreatment pretreatment NN cord-006856-b1w25ob5 1924 19 with with IN cord-006856-b1w25ob5 1924 20 caspofungin caspofungin NNP cord-006856-b1w25ob5 1924 21 for for IN cord-006856-b1w25ob5 1924 22 non non JJ cord-006856-b1w25ob5 1924 23 - - JJ cord-006856-b1w25ob5 1924 24 albicans albicans JJ cord-006856-b1w25ob5 1924 25 Candida candida NN cord-006856-b1w25ob5 1924 26 wound wind VBD cord-006856-b1w25ob5 1924 27 infection infection NN cord-006856-b1w25ob5 1924 28 . . . cord-006856-b1w25ob5 1925 1 One one CD cord-006856-b1w25ob5 1925 2 patient patient NN cord-006856-b1w25ob5 1925 3 died die VBD cord-006856-b1w25ob5 1925 4 due due IN cord-006856-b1w25ob5 1925 5 to to IN cord-006856-b1w25ob5 1925 6 aspergillosis aspergillosis NN cord-006856-b1w25ob5 1925 7 following follow VBG cord-006856-b1w25ob5 1925 8 his -PRON- PRP$ cord-006856-b1w25ob5 1925 9 second second JJ cord-006856-b1w25ob5 1925 10 pancreas pancreas NN cord-006856-b1w25ob5 1925 11 retransplant retransplant NN cord-006856-b1w25ob5 1925 12 . . . cord-006856-b1w25ob5 1926 1 Three three CD cord-006856-b1w25ob5 1926 2 cases case NNS cord-006856-b1w25ob5 1926 3 of of IN cord-006856-b1w25ob5 1926 4 aspergillosis aspergillosis NNP cord-006856-b1w25ob5 1926 5 were be VBD cord-006856-b1w25ob5 1926 6 successfully successfully RB cord-006856-b1w25ob5 1926 7 treated treat VBN cord-006856-b1w25ob5 1926 8 using use VBG cord-006856-b1w25ob5 1926 9 liposomal liposomal VBN cord-006856-b1w25ob5 1926 10 AmphotericinB amphotericinb CD cord-006856-b1w25ob5 1926 11 in in IN cord-006856-b1w25ob5 1926 12 one one CD cord-006856-b1w25ob5 1926 13 and and CC cord-006856-b1w25ob5 1926 14 a a DT cord-006856-b1w25ob5 1926 15 combination combination NN cord-006856-b1w25ob5 1926 16 of of IN cord-006856-b1w25ob5 1926 17 caspofungin caspofungin NNP cord-006856-b1w25ob5 1926 18 and and CC cord-006856-b1w25ob5 1926 19 voriconazol voriconazol NNP cord-006856-b1w25ob5 1926 20 in in IN cord-006856-b1w25ob5 1926 21 two two CD cord-006856-b1w25ob5 1926 22 cases case NNS cord-006856-b1w25ob5 1926 23 . . . cord-006856-b1w25ob5 1927 1 This this DT cord-006856-b1w25ob5 1927 2 combination combination NN cord-006856-b1w25ob5 1927 3 was be VBD cord-006856-b1w25ob5 1927 4 also also RB cord-006856-b1w25ob5 1927 5 used use VBN cord-006856-b1w25ob5 1927 6 in in IN cord-006856-b1w25ob5 1927 7 a a DT cord-006856-b1w25ob5 1927 8 patient patient NN cord-006856-b1w25ob5 1927 9 who who WP cord-006856-b1w25ob5 1927 10 developed develop VBD cord-006856-b1w25ob5 1927 11 intra intra JJ cord-006856-b1w25ob5 1927 12 - - JJ cord-006856-b1w25ob5 1927 13 abdominal abdominal JJ cord-006856-b1w25ob5 1927 14 infection infection NN cord-006856-b1w25ob5 1927 15 with with IN cord-006856-b1w25ob5 1927 16 Candida Candida NNP cord-006856-b1w25ob5 1927 17 krusei krusei NNP cord-006856-b1w25ob5 1927 18 . . . cord-006856-b1w25ob5 1928 1 The the DT cord-006856-b1w25ob5 1928 2 remaining remain VBG cord-006856-b1w25ob5 1928 3 infections infection NNS cord-006856-b1w25ob5 1928 4 were be VBD cord-006856-b1w25ob5 1928 5 due due JJ cord-006856-b1w25ob5 1928 6 to to IN cord-006856-b1w25ob5 1928 7 Candida Candida NNP cord-006856-b1w25ob5 1928 8 albicans albican NNS cord-006856-b1w25ob5 1928 9 including include VBG cord-006856-b1w25ob5 1928 10 six six CD cord-006856-b1w25ob5 1928 11 cases case NNS cord-006856-b1w25ob5 1928 12 of of IN cord-006856-b1w25ob5 1928 13 intra intra JJ cord-006856-b1w25ob5 1928 14 - - JJ cord-006856-b1w25ob5 1928 15 abdominal abdominal JJ cord-006856-b1w25ob5 1928 16 infection infection NN cord-006856-b1w25ob5 1928 17 , , , cord-006856-b1w25ob5 1928 18 one one CD cord-006856-b1w25ob5 1928 19 urinary urinary JJ cord-006856-b1w25ob5 1928 20 tract tract NN cord-006856-b1w25ob5 1928 21 infection infection NN cord-006856-b1w25ob5 1928 22 , , , cord-006856-b1w25ob5 1928 23 and and CC cord-006856-b1w25ob5 1928 24 one one CD cord-006856-b1w25ob5 1928 25 mucocutaneous mucocutaneous JJ cord-006856-b1w25ob5 1928 26 candidiasis candidiasis NN cord-006856-b1w25ob5 1928 27 . . . cord-006856-b1w25ob5 1929 1 Type Type NNP cord-006856-b1w25ob5 1929 2 II ii CD cord-006856-b1w25ob5 1929 3 diabetics diabetic NNS cord-006856-b1w25ob5 1929 4 were be VBD cord-006856-b1w25ob5 1929 5 found find VBN cord-006856-b1w25ob5 1929 6 at at IN cord-006856-b1w25ob5 1929 7 increased increase VBN cord-006856-b1w25ob5 1929 8 risk risk NN cord-006856-b1w25ob5 1929 9 for for IN cord-006856-b1w25ob5 1929 10 fungal fungal JJ cord-006856-b1w25ob5 1929 11 infection infection NN cord-006856-b1w25ob5 1929 12 . . . cord-006856-b1w25ob5 1930 1 Conclusions conclusion NNS cord-006856-b1w25ob5 1930 2 . . . cord-006856-b1w25ob5 1931 1 Fungal fungal JJ cord-006856-b1w25ob5 1931 2 infections infection NNS cord-006856-b1w25ob5 1931 3 represent represent VBP cord-006856-b1w25ob5 1931 4 frequent frequent JJ cord-006856-b1w25ob5 1931 5 and and CC cord-006856-b1w25ob5 1931 6 life life NN cord-006856-b1w25ob5 1931 7 - - HYPH cord-006856-b1w25ob5 1931 8 threatening threaten VBG cord-006856-b1w25ob5 1931 9 complications complication NNS cord-006856-b1w25ob5 1931 10 after after IN cord-006856-b1w25ob5 1931 11 PTx PTx NNS cord-006856-b1w25ob5 1931 12 . . . cord-006856-b1w25ob5 1932 1 They -PRON- PRP cord-006856-b1w25ob5 1932 2 are be VBP cord-006856-b1w25ob5 1932 3 amongst amongst IN cord-006856-b1w25ob5 1932 4 the the DT cord-006856-b1w25ob5 1932 5 most most RBS cord-006856-b1w25ob5 1932 6 common common JJ cord-006856-b1w25ob5 1932 7 causes cause NNS cord-006856-b1w25ob5 1932 8 of of IN cord-006856-b1w25ob5 1932 9 graft graft NN cord-006856-b1w25ob5 1932 10 loss loss NN cord-006856-b1w25ob5 1932 11 and and CC cord-006856-b1w25ob5 1932 12 death death NN cord-006856-b1w25ob5 1932 13 . . . cord-006856-b1w25ob5 1933 1 Non Non NNS cord-006856-b1w25ob5 1933 2 - - NNS cord-006856-b1w25ob5 1933 3 albicans albicans JJ cord-006856-b1w25ob5 1933 4 Candida candida NN cord-006856-b1w25ob5 1933 5 strains strain NNS cord-006856-b1w25ob5 1933 6 are be VBP cord-006856-b1w25ob5 1933 7 increasingly increasingly RB cord-006856-b1w25ob5 1933 8 isolated isolate VBN cord-006856-b1w25ob5 1933 9 and and CC cord-006856-b1w25ob5 1933 10 the the DT cord-006856-b1w25ob5 1933 11 incidence incidence NN cord-006856-b1w25ob5 1933 12 of of IN cord-006856-b1w25ob5 1933 13 filamentous filamentous JJ cord-006856-b1w25ob5 1933 14 fungal fungal JJ cord-006856-b1w25ob5 1933 15 infections infection NNS cord-006856-b1w25ob5 1933 16 has have VBZ cord-006856-b1w25ob5 1933 17 increased increase VBN cord-006856-b1w25ob5 1933 18 during during IN cord-006856-b1w25ob5 1933 19 the the DT cord-006856-b1w25ob5 1933 20 study study NN cord-006856-b1w25ob5 1933 21 period period NN cord-006856-b1w25ob5 1933 22 parallel parallel JJ cord-006856-b1w25ob5 1933 23 to to IN cord-006856-b1w25ob5 1933 24 a a DT cord-006856-b1w25ob5 1933 25 decreasing decrease VBG cord-006856-b1w25ob5 1933 26 rejection rejection NN cord-006856-b1w25ob5 1933 27 rate rate NN cord-006856-b1w25ob5 1933 28 . . . cord-006856-b1w25ob5 1934 1 C57BL/6 C57BL/6 NNP cord-006856-b1w25ob5 1934 2 ( ( -LRB- cord-006856-b1w25ob5 1934 3 H-2 H-2 NNP cord-006856-b1w25ob5 1934 4 b b NN cord-006856-b1w25ob5 1934 5 ) ) -RRB- cord-006856-b1w25ob5 1934 6 mice mouse NNS cord-006856-b1w25ob5 1934 7 received receive VBD cord-006856-b1w25ob5 1934 8 a a DT cord-006856-b1w25ob5 1934 9 total total JJ cord-006856-b1w25ob5 1934 10 - - HYPH cord-006856-b1w25ob5 1934 11 body body NN cord-006856-b1w25ob5 1934 12 irradiation irradiation NN cord-006856-b1w25ob5 1934 13 ( ( -LRB- cord-006856-b1w25ob5 1934 14 TBI TBI NNP cord-006856-b1w25ob5 1934 15 , , , cord-006856-b1w25ob5 1934 16 d-1 d-1 NNP cord-006856-b1w25ob5 1934 17 ) ) -RRB- cord-006856-b1w25ob5 1934 18 of of IN cord-006856-b1w25ob5 1934 19 3 3 CD cord-006856-b1w25ob5 1934 20 Gy Gy NNP cord-006856-b1w25ob5 1934 21 and and CC cord-006856-b1w25ob5 1934 22 costimulation costimulation NN cord-006856-b1w25ob5 1934 23 blockade blockade NN cord-006856-b1w25ob5 1934 24 consisting consist VBG cord-006856-b1w25ob5 1934 25 of of IN cord-006856-b1w25ob5 1934 26 anti anti JJ cord-006856-b1w25ob5 1934 27 - - JJ cord-006856-b1w25ob5 1934 28 CD154 cd154 CD cord-006856-b1w25ob5 1934 29 mAb mAb NNS cord-006856-b1w25ob5 1934 30 ( ( -LRB- cord-006856-b1w25ob5 1934 31 1 1 CD cord-006856-b1w25ob5 1934 32 mg mg NN cord-006856-b1w25ob5 1934 33 , , , cord-006856-b1w25ob5 1934 34 d0 d0 NNP cord-006856-b1w25ob5 1934 35 ) ) -RRB- cord-006856-b1w25ob5 1935 1 Vß11 Vß11 NNP cord-006856-b1w25ob5 1936 1 + + CC cord-006856-b1w25ob5 1936 2 CD4-cells cd4-cell NNS cord-006856-b1w25ob5 1936 3 , , , cord-006856-b1w25ob5 1936 4 P p NN cord-006856-b1w25ob5 1936 5 < < XX cord-006856-b1w25ob5 1936 6 0.05 0.05 CD cord-006856-b1w25ob5 1936 7 ) ) -RRB- cord-006856-b1w25ob5 1936 8 . . . cord-006856-b1w25ob5 1937 1 Donor donor NN cord-006856-b1w25ob5 1937 2 skin skin NN cord-006856-b1w25ob5 1937 3 acceptance acceptance NN cord-006856-b1w25ob5 1937 4 FTY720 FTY720 NNP cord-006856-b1w25ob5 1937 5 is be VBZ cord-006856-b1w25ob5 1937 6 the the DT cord-006856-b1w25ob5 1937 7 first first JJ cord-006856-b1w25ob5 1937 8 agent agent NN cord-006856-b1w25ob5 1937 9 in in IN cord-006856-b1w25ob5 1937 10 a a DT cord-006856-b1w25ob5 1937 11 new new JJ cord-006856-b1w25ob5 1937 12 class class NN cord-006856-b1w25ob5 1937 13 of of IN cord-006856-b1w25ob5 1937 14 immunomodulators immunomodulator NNS cord-006856-b1w25ob5 1937 15 termed term VBN cord-006856-b1w25ob5 1937 16 Sphingosine-1-Phosphate Sphingosine-1-Phosphate NNP cord-006856-b1w25ob5 1937 17 ( ( -LRB- cord-006856-b1w25ob5 1937 18 S1P s1p NN cord-006856-b1w25ob5 1937 19 ) ) -RRB- cord-006856-b1w25ob5 1937 20 human human JJ cord-006856-b1w25ob5 1937 21 DC DC NNP cord-006856-b1w25ob5 1937 22 , , , cord-006856-b1w25ob5 1937 23 which which WDT cord-006856-b1w25ob5 1937 24 are be VBP cord-006856-b1w25ob5 1937 25 known know VBN cord-006856-b1w25ob5 1937 26 to to TO cord-006856-b1w25ob5 1937 27 express express VB cord-006856-b1w25ob5 1937 28 mRNA mrna NN cord-006856-b1w25ob5 1937 29 for for IN cord-006856-b1w25ob5 1937 30 S1P s1p NN cord-006856-b1w25ob5 1937 31 1 1 CD cord-006856-b1w25ob5 1937 32 , , , cord-006856-b1w25ob5 1937 33 S1P s1p CD cord-006856-b1w25ob5 1937 34 2 2 CD cord-006856-b1w25ob5 1937 35 , , , cord-006856-b1w25ob5 1937 36 S1P s1p NN cord-006856-b1w25ob5 1937 37 3 3 CD cord-006856-b1w25ob5 1937 38 and and CC cord-006856-b1w25ob5 1937 39 S1P s1p NN cord-006856-b1w25ob5 1937 40 4 4 CD cord-006856-b1w25ob5 1937 41 , , , cord-006856-b1w25ob5 1937 42 have have VBP cord-006856-b1w25ob5 1937 43 not not RB cord-006856-b1w25ob5 1937 44 been be VBN cord-006856-b1w25ob5 1937 45 described describe VBN cord-006856-b1w25ob5 1937 46 so so RB cord-006856-b1w25ob5 1937 47 far far RB cord-006856-b1w25ob5 1937 48 . . . cord-006856-b1w25ob5 1938 1 Methods method NNS cord-006856-b1w25ob5 1938 2 . . . cord-006856-b1w25ob5 1939 1 To to TO cord-006856-b1w25ob5 1939 2 elucidate elucidate VB cord-006856-b1w25ob5 1939 3 for for IN cord-006856-b1w25ob5 1939 4 the the DT cord-006856-b1w25ob5 1939 5 first first JJ cord-006856-b1w25ob5 1939 6 time time NN cord-006856-b1w25ob5 1939 7 the the DT cord-006856-b1w25ob5 1939 8 influence influence NN cord-006856-b1w25ob5 1939 9 of of IN cord-006856-b1w25ob5 1939 10 S1P s1p CD cord-006856-b1w25ob5 1939 11 receptor receptor NN cord-006856-b1w25ob5 1939 12 agonists agonist NNS cord-006856-b1w25ob5 1939 13 on on IN cord-006856-b1w25ob5 1939 14 human human JJ cord-006856-b1w25ob5 1939 15 monocyte monocyte NNP cord-006856-b1w25ob5 1939 16 - - HYPH cord-006856-b1w25ob5 1939 17 derived derive VBN cord-006856-b1w25ob5 1939 18 DC DC NNP cord-006856-b1w25ob5 1939 19 ( ( -LRB- cord-006856-b1w25ob5 1939 20 mo mo NNP cord-006856-b1w25ob5 1939 21 - - HYPH cord-006856-b1w25ob5 1939 22 DC DC NNP cord-006856-b1w25ob5 1939 23 ) ) -RRB- cord-006856-b1w25ob5 1939 24 , , , cord-006856-b1w25ob5 1939 25 we -PRON- PRP cord-006856-b1w25ob5 1939 26 used use VBD cord-006856-b1w25ob5 1939 27 therapeutically therapeutically RB cord-006856-b1w25ob5 1939 28 relevant relevant JJ cord-006856-b1w25ob5 1939 29 concentrations concentration NNS cord-006856-b1w25ob5 1939 30 ( ( -LRB- cord-006856-b1w25ob5 1939 31 2 2 CD cord-006856-b1w25ob5 1939 32 - - SYM cord-006856-b1w25ob5 1939 33 200 200 CD cord-006856-b1w25ob5 1939 34 ng ng NN cord-006856-b1w25ob5 1939 35 / / SYM cord-006856-b1w25ob5 1939 36 ml ml NN cord-006856-b1w25ob5 1939 37 ) ) -RRB- cord-006856-b1w25ob5 1939 38 of of IN cord-006856-b1w25ob5 1939 39 FTY720 FTY720 NNP cord-006856-b1w25ob5 1939 40 and and CC cord-006856-b1w25ob5 1939 41 its -PRON- PRP$ cord-006856-b1w25ob5 1939 42 phosphorylated phosphorylated JJ cord-006856-b1w25ob5 1939 43 metabolite metabolite NN cord-006856-b1w25ob5 1939 44 FTY720-P FTY720-P NNP cord-006856-b1w25ob5 1939 45 and and CC cord-006856-b1w25ob5 1939 46 investigated investigate VBD cord-006856-b1w25ob5 1939 47 their -PRON- PRP$ cord-006856-b1w25ob5 1939 48 effects effect NNS cord-006856-b1w25ob5 1939 49 on on IN cord-006856-b1w25ob5 1939 50 DC DC NNP cord-006856-b1w25ob5 1939 51 surface surface NN cord-006856-b1w25ob5 1939 52 marker marker NN cord-006856-b1w25ob5 1939 53 expression expression NN cord-006856-b1w25ob5 1939 54 ( ( -LRB- cord-006856-b1w25ob5 1939 55 lineage lineage NN cord-006856-b1w25ob5 1939 56 markers marker NNS cord-006856-b1w25ob5 1939 57 , , , cord-006856-b1w25ob5 1939 58 costimulatory costimulatory NN cord-006856-b1w25ob5 1939 59 and and CC cord-006856-b1w25ob5 1939 60 adhesion adhesion NN cord-006856-b1w25ob5 1939 61 molecules molecule NNS cord-006856-b1w25ob5 1939 62 , , , cord-006856-b1w25ob5 1939 63 chemokine chemokine NN cord-006856-b1w25ob5 1939 64 receptors receptor NNS cord-006856-b1w25ob5 1939 65 ) ) -RRB- cord-006856-b1w25ob5 1939 66 , , , cord-006856-b1w25ob5 1939 67 protein protein NN cord-006856-b1w25ob5 1939 68 levels level NNS cord-006856-b1w25ob5 1939 69 of of IN cord-006856-b1w25ob5 1939 70 S1P s1p NN cord-006856-b1w25ob5 1939 71 receptors receptor NNS cord-006856-b1w25ob5 1939 72 and and CC cord-006856-b1w25ob5 1939 73 DC DC NNP cord-006856-b1w25ob5 1939 74 effector effector NN cord-006856-b1w25ob5 1939 75 functions function NNS cord-006856-b1w25ob5 1939 76 : : : cord-006856-b1w25ob5 1939 77 antigen antigen NNP cord-006856-b1w25ob5 1939 78 uptake uptake NN cord-006856-b1w25ob5 1939 79 CCL19 CCL19 NNP cord-006856-b1w25ob5 1939 80 / / SYM cord-006856-b1w25ob5 1939 81 ELC ELC NNP cord-006856-b1w25ob5 1939 82 ; ; : cord-006856-b1w25ob5 1939 83 or or CC cord-006856-b1w25ob5 1939 84 FTY720-P FTY720-P NNP cord-006856-b1w25ob5 1939 85 - - HYPH cord-006856-b1w25ob5 1939 86 treated treat VBN cord-006856-b1w25ob5 1939 87 mDC mDC NNS cord-006856-b1w25ob5 1939 88 ( ( -LRB- cord-006856-b1w25ob5 1939 89 53 53 CD cord-006856-b1w25ob5 1939 90 % % NN cord-006856-b1w25ob5 1939 91 vs. vs. IN cord-006856-b1w25ob5 1939 92 49 49 CD cord-006856-b1w25ob5 1939 93 % % NN cord-006856-b1w25ob5 1939 94 ; ; , cord-006856-b1w25ob5 1939 95 untreated untreated JJ cord-006856-b1w25ob5 1939 96 DC DC NNP cord-006856-b1w25ob5 1939 97 , , , cord-006856-b1w25ob5 1939 98 72 72 CD cord-006856-b1w25ob5 1939 99 % % NN cord-006856-b1w25ob5 1939 100 ) ) -RRB- cord-006856-b1w25ob5 1940 1 24 24 CD cord-006856-b1w25ob5 1940 2 - - SYM cord-006856-b1w25ob5 1940 3 25 25 CD cord-006856-b1w25ob5 1941 1 Datenkonvertierung Datenkonvertierung NNP cord-006856-b1w25ob5 1941 2 und und IN cord-006856-b1w25ob5 1941 3 Umbruch Umbruch NNP cord-006856-b1w25ob5 1941 4 : : : cord-006856-b1w25ob5 1942 1 Manz Manz NNP cord-006856-b1w25ob5 1942 2 Crossmedia Crossmedia NNP cord-006856-b1w25ob5 1942 3 Druckerei Druckerei NNP cord-006856-b1w25ob5 1942 4 Ferdinand Ferdinand NNP cord-006856-b1w25ob5 1942 5 Berger Berger NNP cord-006856-b1w25ob5 1942 6 & & CC cord-006856-b1w25ob5 1942 7 Söhne Söhne NNP cord-006856-b1w25ob5 1942 8 Gesellschaft Gesellschaft NNP cord-006856-b1w25ob5 1942 9 m. m. NN cord-006856-b1w25ob5 1942 10 b. b. NNP cord-006856-b1w25ob5 1942 11 H. H. NNP cord-006856-b1w25ob5 1942 12 , , , cord-006856-b1w25ob5 1942 13 3580 3580 CD cord-006856-b1w25ob5 1942 14 Horn Horn NNP cord-006856-b1w25ob5 1942 15 , , , cord-006856-b1w25ob5 1942 16 Österreich Österreich NNP cord-006856-b1w25ob5 1942 17 . . . cord-006856-b1w25ob5 1943 1 -Verlagsort -Verlagsort : cord-006856-b1w25ob5 1943 2 : : : cord-006856-b1w25ob5 1944 1 Wien Wien NNP cord-006856-b1w25ob5 1944 2 . . . cord-006856-b1w25ob5 1945 1 -Herstellungsort -Herstellungsort : cord-006856-b1w25ob5 1945 2 : : : cord-006856-b1w25ob5 1945 3 Horn Horn NNP cord-006856-b1w25ob5 1945 4 . . . cord-006856-b1w25ob5 1946 1 Printed print VBN cord-006856-b1w25ob5 1946 2 in in IN cord-006856-b1w25ob5 1946 3 Austria Austria NNP cord-006856-b1w25ob5 1947 1 P. P. NNP cord-006856-b1w25ob5 1947 2 b. b. NNP cord-006856-b1w25ob5 1947 3 b. b. NNP cord-006856-b1w25ob5 1947 4 / / SYM cord-006856-b1w25ob5 1947 5 Erscheinungsort Erscheinungsort NNP cord-006856-b1w25ob5 1947 6 : : : cord-006856-b1w25ob5 1948 1 Wien Wien NNP cord-006856-b1w25ob5 1948 2 / / SYM cord-006856-b1w25ob5 1948 3 Verlagspostamt Verlagspostamt NNP cord-006856-b1w25ob5 1948 4 1201 1201 CD cord-006856-b1w25ob5 1949 1 Wien Wien NNP cord-006856-b1w25ob5 1949 2 -Fachkurzinformation -Fachkurzinformation NNP cord-006856-b1w25ob5 1950 1 Rapamune Rapamune NNP cord-006856-b1w25ob5 1950 2 1 1 CD cord-006856-b1w25ob5 1950 3 mg mg NNP cord-006856-b1w25ob5 1950 4 bzw bzw NNP cord-006856-b1w25ob5 1950 5 . . . cord-006856-b1w25ob5 1951 1 2 2 CD cord-006856-b1w25ob5 1951 2 mg mg NNP cord-006856-b1w25ob5 1951 3 überzogene überzogene JJ cord-006856-b1w25ob5 1951 4 Tablette Tablette NNP cord-006856-b1w25ob5 1951 5 ; ; : cord-006856-b1w25ob5 1951 6 Rapamune Rapamune NNP cord-006856-b1w25ob5 1951 7 1 1 CD cord-006856-b1w25ob5 1951 8 mg mg NNP cord-006856-b1w25ob5 1951 9 / / SYM cord-006856-b1w25ob5 1951 10 ml ml NNP cord-006856-b1w25ob5 1951 11 bzw bzw NNP cord-006856-b1w25ob5 1951 12 . . . cord-006856-b1w25ob5 1952 1 1mg/ 1mg/ CD cord-006856-b1w25ob5 1953 1 1ml 1ml NNP cord-006856-b1w25ob5 1953 2 bzw bzw NNP cord-006856-b1w25ob5 1953 3 . . . cord-006856-b1w25ob5 1954 1 2 2 LS cord-006856-b1w25ob5 1954 2 mg/2ml mg/2ml XX cord-006856-b1w25ob5 1955 1 Lösung Lösung NNP cord-006856-b1w25ob5 1955 2 zum zum NNP cord-006856-b1w25ob5 1955 3 Einnehmen Einnehmen NNP cord-006856-b1w25ob5 1955 4 Wirkstoff Wirkstoff NNP cord-006856-b1w25ob5 1955 5 : : : cord-006856-b1w25ob5 1956 1 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1956 2 Zusammensetzung Zusammensetzung NNP cord-006856-b1w25ob5 1956 3 : : : cord-006856-b1w25ob5 1957 1 1 1 CD cord-006856-b1w25ob5 1957 2 Tablette Tablette NNP cord-006856-b1w25ob5 1957 3 enthält enthält NNP cord-006856-b1w25ob5 1957 4 1 1 CD cord-006856-b1w25ob5 1957 5 mg mg NNP cord-006856-b1w25ob5 1957 6 bzw bzw NNP cord-006856-b1w25ob5 1957 7 . . . cord-006856-b1w25ob5 1958 1 2 2 CD cord-006856-b1w25ob5 1958 2 mg mg NNP cord-006856-b1w25ob5 1958 3 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1958 4 . . . cord-006856-b1w25ob5 1959 1 1 1 CD cord-006856-b1w25ob5 1959 2 ml ml NNP cord-006856-b1w25ob5 1959 3 Lösung Lösung NNP cord-006856-b1w25ob5 1959 4 enthält enthält NNP cord-006856-b1w25ob5 1960 1 1 1 CD cord-006856-b1w25ob5 1960 2 mg mg NNP cord-006856-b1w25ob5 1960 3 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1960 4 . . . cord-006856-b1w25ob5 1961 1 1Beutel 1beutel LS cord-006856-b1w25ob5 1961 2 zu zu NNP cord-006856-b1w25ob5 1961 3 1 1 CD cord-006856-b1w25ob5 1961 4 ml ml NN cord-006856-b1w25ob5 1961 5 bzw bzw NNP cord-006856-b1w25ob5 1961 6 . . . cord-006856-b1w25ob5 1962 1 2 2 LS cord-006856-b1w25ob5 1962 2 ml ml NN cord-006856-b1w25ob5 1962 3 enthält enthält NNP cord-006856-b1w25ob5 1962 4 : : : cord-006856-b1w25ob5 1962 5 1 1 CD cord-006856-b1w25ob5 1962 6 mg mg NNP cord-006856-b1w25ob5 1962 7 bzw bzw NNP cord-006856-b1w25ob5 1962 8 . . . cord-006856-b1w25ob5 1963 1 2 2 CD cord-006856-b1w25ob5 1963 2 mg mg NNP cord-006856-b1w25ob5 1963 3 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1963 4 . . . cord-006856-b1w25ob5 1964 1 Sonstige Sonstige NNP cord-006856-b1w25ob5 1964 2 Bestandteile Bestandteile NNP cord-006856-b1w25ob5 1964 3 : : : cord-006856-b1w25ob5 1964 4 Tablettenkern Tablettenkern NNP cord-006856-b1w25ob5 1964 5 : : : cord-006856-b1w25ob5 1964 6 Laktose Laktose NNP cord-006856-b1w25ob5 1964 7 - - HYPH cord-006856-b1w25ob5 1964 8 Monohydrat Monohydrat NNP cord-006856-b1w25ob5 1964 9 , , , cord-006856-b1w25ob5 1964 10 Macrogol Macrogol NNP cord-006856-b1w25ob5 1964 11 , , , cord-006856-b1w25ob5 1964 12 Magnesiumstearat Magnesiumstearat NNP cord-006856-b1w25ob5 1964 13 , , , cord-006856-b1w25ob5 1964 14 Talkum Talkum NNP cord-006856-b1w25ob5 1964 15 , , , cord-006856-b1w25ob5 1965 1 Tablettenüberzug Tablettenüberzug NNP cord-006856-b1w25ob5 1965 2 : : : cord-006856-b1w25ob5 1966 1 Macrogol Macrogol NNP cord-006856-b1w25ob5 1967 1 Engmaschige Engmaschige NNP cord-006856-b1w25ob5 1967 2 Überwachung Überwachung NNP cord-006856-b1w25ob5 1967 3 der der NNP cord-006856-b1w25ob5 1967 4 Sirolimus Sirolimus NNP cord-006856-b1w25ob5 1967 5 - - HYPH cord-006856-b1w25ob5 1967 6 Talspiegel Talspiegel NNP cord-006856-b1w25ob5 1968 1 i -PRON- PRP cord-006856-b1w25ob5 1968 2 m be VBP cord-006856-b1w25ob5 1968 3 Vollblut Vollblut NNP cord-006856-b1w25ob5 1968 4 bei bei NNP cord-006856-b1w25ob5 1968 5 : : : cord-006856-b1w25ob5 1969 1 leichter leichter NNP cord-006856-b1w25ob5 1969 2 bis bis NNP cord-006856-b1w25ob5 1969 3 mittelgradiger mittelgradiger NNP cord-006856-b1w25ob5 1969 4 Leberfunktionsstörung Leberfunktionsstörung NNP cord-006856-b1w25ob5 1969 5 ; ; : cord-006856-b1w25ob5 1969 6 gleichzeitiger gleichzeitiger NNP cord-006856-b1w25ob5 1969 7 Verabreichung Verabreichung NNP cord-006856-b1w25ob5 1969 8 starker stark JJR cord-006856-b1w25ob5 1969 9 CYP3A4-Induktoren CYP3A4-Induktoren NNP cord-006856-b1w25ob5 1970 1 oder oder NNP cord-006856-b1w25ob5 1971 1 -Inhibitoren -Inhibitoren NNP cord-006856-b1w25ob5 1971 2 sowie sowie NNP cord-006856-b1w25ob5 1971 3 nach nach NNP cord-006856-b1w25ob5 1971 4 deren deren NNP cord-006856-b1w25ob5 1971 5 Absetzen Absetzen NNP cord-006856-b1w25ob5 1972 1 ; ; : cord-006856-b1w25ob5 1972 2 bei bei NNP cord-006856-b1w25ob5 1972 3 Absetzen Absetzen NNP cord-006856-b1w25ob5 1972 4 oder oder NNP cord-006856-b1w25ob5 1973 1 deutlicher deutlicher NNP cord-006856-b1w25ob5 1973 2 Dosisreduktion Dosisreduktion NNP cord-006856-b1w25ob5 1973 3 von von NNP cord-006856-b1w25ob5 1973 4 Ciclosporin Ciclosporin NNP cord-006856-b1w25ob5 1973 5 . . . cord-006856-b1w25ob5 1974 1 Begrenzte Begrenzte NNP cord-006856-b1w25ob5 1975 1 Exposition exposition NN cord-006856-b1w25ob5 1975 2 gegenüber gegenüber NNP cord-006856-b1w25ob5 1975 3 Sonnen Sonnen NNP cord-006856-b1w25ob5 1975 4 - - HYPH cord-006856-b1w25ob5 1975 5 und und NNP cord-006856-b1w25ob5 1975 6 UV uv NN cord-006856-b1w25ob5 1975 7 - - HYPH cord-006856-b1w25ob5 1975 8 Strahlung Strahlung NNP cord-006856-b1w25ob5 1975 9 bei bei NNP cord-006856-b1w25ob5 1975 10 Patienten Patienten NNP cord-006856-b1w25ob5 1975 11 mit mit NNP cord-006856-b1w25ob5 1975 12 einem einem NNP cord-006856-b1w25ob5 1975 13 erhöhten erhöhten NNP cord-006856-b1w25ob5 1975 14 Risiko Risiko NNP cord-006856-b1w25ob5 1975 15 für für IN cord-006856-b1w25ob5 1975 16 Hautkrebs Hautkrebs NNP cord-006856-b1w25ob5 1975 17 . . . cord-006856-b1w25ob5 1976 1 Antimikrobielle Antimikrobielle NNP cord-006856-b1w25ob5 1977 1 Prophylaxe Prophylaxe NNP cord-006856-b1w25ob5 1978 1 gegen gegen NNP cord-006856-b1w25ob5 1978 2 Pneumocystis Pneumocystis NNP cord-006856-b1w25ob5 1978 3 carinii carinii FW cord-006856-b1w25ob5 1978 4 Pneumonie Pneumonie NNP cord-006856-b1w25ob5 1979 1 während während NNP cord-006856-b1w25ob5 1979 2 der der NNP cord-006856-b1w25ob5 1979 3 ersten ersten NNP cord-006856-b1w25ob5 1980 1 12 12 CD cord-006856-b1w25ob5 1980 2 Monate Monate NNP cord-006856-b1w25ob5 1980 3 nach nach NNP cord-006856-b1w25ob5 1980 4 der der NNP cord-006856-b1w25ob5 1980 5 Transplantation Transplantation NNP cord-006856-b1w25ob5 1980 6 sowie sowie NNP cord-006856-b1w25ob5 1980 7 eine eine NNP cord-006856-b1w25ob5 1980 8 Zytomegalievirus Zytomegalievirus NNP cord-006856-b1w25ob5 1980 9 ( ( -LRB- cord-006856-b1w25ob5 1980 10 CMV)-Prophylaxe CMV)-Prophylaxe NNP cord-006856-b1w25ob5 1980 11 über über NNP cord-006856-b1w25ob5 1980 12 3 3 CD cord-006856-b1w25ob5 1980 13 Monate Monate NNP cord-006856-b1w25ob5 1980 14 nach nach NN cord-006856-b1w25ob5 1980 15 der der NNP cord-006856-b1w25ob5 1980 16 Transplantation transplantation NN cord-006856-b1w25ob5 1980 17 ( ( -LRB- cord-006856-b1w25ob5 1981 1 insbesondere insbesondere NNP cord-006856-b1w25ob5 1981 2 für für NNP cord-006856-b1w25ob5 1981 3 Patienten Patienten NNP cord-006856-b1w25ob5 1981 4 mit mit NNP cord-006856-b1w25ob5 1981 5 einem einem NNP cord-006856-b1w25ob5 1981 6 erhöhten erhöhten NNP cord-006856-b1w25ob5 1981 7 Risiko Risiko NNP cord-006856-b1w25ob5 1981 8 für für IN cord-006856-b1w25ob5 1981 9 eine eine NNP cord-006856-b1w25ob5 1981 10 CMV CMV NNP cord-006856-b1w25ob5 1981 11 - - HYPH cord-006856-b1w25ob5 1981 12 Erkrankung Erkrankung NNP cord-006856-b1w25ob5 1981 13 ) ) -RRB- cord-006856-b1w25ob5 1981 14 empfohlen empfohlen NN cord-006856-b1w25ob5 1981 15 . . . cord-006856-b1w25ob5 1982 1 In in IN cord-006856-b1w25ob5 1982 2 Kombination Kombination NNP cord-006856-b1w25ob5 1982 3 mit mit NNP cord-006856-b1w25ob5 1982 4 einem einem NNP cord-006856-b1w25ob5 1982 5 HMG HMG NNP cord-006856-b1w25ob5 1982 6 - - HYPH cord-006856-b1w25ob5 1982 7 CoA CoA NNP cord-006856-b1w25ob5 1982 8 - - HYPH cord-006856-b1w25ob5 1982 9 Reduktaseinhibitor Reduktaseinhibitor NNP cord-006856-b1w25ob5 1982 10 oder oder NNP cord-006856-b1w25ob5 1982 11 Fibrat Fibrat NNP cord-006856-b1w25ob5 1983 1 Überwachung Überwachung NNP cord-006856-b1w25ob5 1984 1 auf auf NNP cord-006856-b1w25ob5 1984 2 Entwicklung Entwicklung NNP cord-006856-b1w25ob5 1984 3 einer einer NNP cord-006856-b1w25ob5 1984 4 Rhabdomyolyse Rhabdomyolyse NNP cord-006856-b1w25ob5 1984 5 und und NNP cord-006856-b1w25ob5 1984 6 anderen anderen NNP cord-006856-b1w25ob5 1984 7 Nebenwirkungen Nebenwirkungen NNP cord-006856-b1w25ob5 1984 8 dieser dieser NNP cord-006856-b1w25ob5 1984 9 Präparate Präparate NNP cord-006856-b1w25ob5 1984 10 . . . cord-006856-b1w25ob5 1985 1 Bei Bei NNP cord-006856-b1w25ob5 1985 2 kombinierter kombinierter NNP cord-006856-b1w25ob5 1985 3 Gabe Gabe NNP cord-006856-b1w25ob5 1985 4 mit mit NNP cord-006856-b1w25ob5 1985 5 Ciclosporin Ciclosporin NNP cord-006856-b1w25ob5 1985 6 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 1985 7 überwachen überwachen NNP cord-006856-b1w25ob5 1985 8 , , , cord-006856-b1w25ob5 1985 9 ggf ggf NNP cord-006856-b1w25ob5 1985 10 . . . cord-006856-b1w25ob5 1986 1 bei bei NNP cord-006856-b1w25ob5 1986 2 erhöhten erhöhten NNP cord-006856-b1w25ob5 1986 3 Serumkreatininspiegeln Serumkreatininspiegeln NNP cord-006856-b1w25ob5 1986 4 eine eine NNP cord-006856-b1w25ob5 1986 5 angemessene angemessene JJ cord-006856-b1w25ob5 1986 6 Dosisanpassung Dosisanpassung NNP cord-006856-b1w25ob5 1986 7 erwägen erwägen NNP cord-006856-b1w25ob5 1986 8 . . . cord-006856-b1w25ob5 1987 1 Vorsicht Vorsicht NNP cord-006856-b1w25ob5 1987 2 bei bei NNP cord-006856-b1w25ob5 1987 3 gleichzeitiger gleichzeitiger NN cord-006856-b1w25ob5 1987 4 Anwendung Anwendung NNP cord-006856-b1w25ob5 1987 5 von von NNP cord-006856-b1w25ob5 1987 6 anderen anderen NNP cord-006856-b1w25ob5 1987 7 Substanzen Substanzen NNP cord-006856-b1w25ob5 1987 8 , , , cord-006856-b1w25ob5 1987 9 die die VB cord-006856-b1w25ob5 1987 10 bekanntermaßen bekanntermaßen NNP cord-006856-b1w25ob5 1987 11 eine eine NNP cord-006856-b1w25ob5 1987 12 schädigende schädigende NNP cord-006856-b1w25ob5 1988 1 Wirkung Wirkung NNP cord-006856-b1w25ob5 1988 2 auf auf NNP cord-006856-b1w25ob5 1988 3 die die VBP cord-006856-b1w25ob5 1988 4 Nierenfunktion Nierenfunktion NNP cord-006856-b1w25ob5 1988 5 haben haben XX cord-006856-b1w25ob5 1989 1 erhöhte erhöhte NNP cord-006856-b1w25ob5 1989 2 Laktat Laktat NNP cord-006856-b1w25ob5 1989 3 - - HYPH cord-006856-b1w25ob5 1989 4 Dehydrogenase Dehydrogenase NNP cord-006856-b1w25ob5 1989 5 ( ( -LRB- cord-006856-b1w25ob5 1989 6 LDH LDH NNP cord-006856-b1w25ob5 1989 7 ) ) -RRB- cord-006856-b1w25ob5 1989 8 , , , cord-006856-b1w25ob5 1989 9 Arthralgie Arthralgie NNP cord-006856-b1w25ob5 1989 10 , , , cord-006856-b1w25ob5 1989 11 Akne Akne NNP cord-006856-b1w25ob5 1989 12 , , , cord-006856-b1w25ob5 1989 13 Infektion Infektion NNP cord-006856-b1w25ob5 1989 14 des des NNP cord-006856-b1w25ob5 1989 15 Harntraktes Harntraktes NNP cord-006856-b1w25ob5 1989 16 Gelegentlich Gelegentlich NNP cord-006856-b1w25ob5 1989 17 : : : cord-006856-b1w25ob5 1989 18 Pankreatitis Pankreatitis NNP cord-006856-b1w25ob5 1989 19 , , , cord-006856-b1w25ob5 1989 20 Lymphom Lymphom NNP cord-006856-b1w25ob5 1989 21 / / SYM cord-006856-b1w25ob5 1989 22 lymphoproliferative lymphoproliferative JJ cord-006856-b1w25ob5 1989 23 Erkrankung Erkrankung NNP cord-006856-b1w25ob5 1989 24 nach nach NNP cord-006856-b1w25ob5 1989 25 Transplantation Transplantation NNP cord-006856-b1w25ob5 1989 26 , , , cord-006856-b1w25ob5 1989 27 Panzytopenie Panzytopenie NNP cord-006856-b1w25ob5 1989 28 . . . cord-006856-b1w25ob5 1990 1 Die die VB cord-006856-b1w25ob5 1990 2 Immunsuppression immunsuppression NN cord-006856-b1w25ob5 1990 3 erhöht erhöht NNP cord-006856-b1w25ob5 1990 4 die die VBP cord-006856-b1w25ob5 1990 5 Anfälligkeit Anfälligkeit NNP cord-006856-b1w25ob5 1990 6 , , , cord-006856-b1w25ob5 1990 7 Lymphome Lymphome NNP cord-006856-b1w25ob5 1990 8 oder oder NNP cord-006856-b1w25ob5 1991 1 andere andere JJ cord-006856-b1w25ob5 1992 1 bösartige bösartige NNP cord-006856-b1w25ob5 1992 2 Neubildungen Neubildungen NNP cord-006856-b1w25ob5 1992 3 , , , cord-006856-b1w25ob5 1992 4 vor vor NNP cord-006856-b1w25ob5 1992 5 allem allem NNP cord-006856-b1w25ob5 1992 6 der der FW cord-006856-b1w25ob5 1992 7 Haut Haut NNP cord-006856-b1w25ob5 1992 8 , , , cord-006856-b1w25ob5 1992 9 zu zu NNP cord-006856-b1w25ob5 1992 10 entwickeln entwickeln NNP cord-006856-b1w25ob5 1992 11 Fachkurzinformation Fachkurzinformation NNP cord-006856-b1w25ob5 1992 12 zu zu NNP cord-006856-b1w25ob5 1992 13 Inserat Inserat NNP cord-006856-b1w25ob5 1992 14 von von NNP cord-006856-b1w25ob5 1992 15 Umschlagseite Umschlagseite NNP cord-006856-b1w25ob5 1992 16 2 2 CD cord-006856-b1w25ob5 1992 17 P08 P08 NNP cord-006856-b1w25ob5 1992 18 Liver Liver NNP cord-006856-b1w25ob5 1992 19 transplantation transplantation NN cord-006856-b1w25ob5 1992 20 for for IN cord-006856-b1w25ob5 1992 21 patients patient NNS cord-006856-b1w25ob5 1992 22 with with IN cord-006856-b1w25ob5 1992 23 hepatitis hepatitis NNP cord-006856-b1w25ob5 1992 24 B b NN cord-006856-b1w25ob5 1992 25 - - HYPH cord-006856-b1w25ob5 1992 26 related relate VBN cord-006856-b1w25ob5 1992 27 liver liver NN cord-006856-b1w25ob5 1992 28 disease disease NN cord-006856-b1w25ob5 1992 29 : : : cord-006856-b1w25ob5 1992 30 A a DT cord-006856-b1w25ob5 1992 31 single single JJ cord-006856-b1w25ob5 1992 32 - - HYPH cord-006856-b1w25ob5 1992 33 center center NN cord-006856-b1w25ob5 1992 34 experience experience NN cord-006856-b1w25ob5 1992 35 L. L. NNP cord-006856-b1w25ob5 1992 36 Hinterhuber Hinterhuber NNP cord-006856-b1w25ob5 1992 37 , , , cord-006856-b1w25ob5 1992 38 I. I. NNP cord-006856-b1w25ob5 1992 39 W. W. NNP cord-006856-b1w25ob5 1992 40 Graziadei Graziadei NNP cord-006856-b1w25ob5 1992 41 Background Background NNP cord-006856-b1w25ob5 1992 42 . . . cord-006856-b1w25ob5 1993 1 Liver liver NN cord-006856-b1w25ob5 1993 2 transplantation transplantation NN cord-006856-b1w25ob5 1993 3 ( ( -LRB- cord-006856-b1w25ob5 1993 4 LT LT NNP cord-006856-b1w25ob5 1993 5 ) ) -RRB- cord-006856-b1w25ob5 1993 6 is be VBZ cord-006856-b1w25ob5 1993 7 the the DT cord-006856-b1w25ob5 1993 8 only only JJ cord-006856-b1w25ob5 1993 9 effective effective JJ cord-006856-b1w25ob5 1993 10 therapy therapy NN cord-006856-b1w25ob5 1993 11 for for IN cord-006856-b1w25ob5 1993 12 end end NN cord-006856-b1w25ob5 1993 13 - - HYPH cord-006856-b1w25ob5 1993 14 stage stage NN cord-006856-b1w25ob5 1993 15 liver liver NN cord-006856-b1w25ob5 1993 16 disease disease NN cord-006856-b1w25ob5 1993 17 due due JJ cord-006856-b1w25ob5 1993 18 to to IN cord-006856-b1w25ob5 1993 19 hepatitis hepatitis NNP cord-006856-b1w25ob5 1993 20 B B NNP cord-006856-b1w25ob5 1993 21 ( ( -LRB- cord-006856-b1w25ob5 1993 22 HBV HBV NNP cord-006856-b1w25ob5 1993 23 ) ) -RRB- cord-006856-b1w25ob5 1993 24 . . . cord-006856-b1w25ob5 1994 1 Before before IN cord-006856-b1w25ob5 1994 2 introduction introduction NN cord-006856-b1w25ob5 1994 3 of of IN cord-006856-b1w25ob5 1994 4 passive passive JJ cord-006856-b1w25ob5 1994 5 immunoprophylaxis immunoprophylaxis NNP cord-006856-b1w25ob5 1994 6 with with IN cord-006856-b1w25ob5 1994 7 hepatitis hepatitis NNP cord-006856-b1w25ob5 1994 8 B B NNP cord-006856-b1w25ob5 1994 9 immunoglobulin immunoglobulin NN cord-006856-b1w25ob5 1994 10 ( ( -LRB- cord-006856-b1w25ob5 1994 11 HBIg HBIg NNS cord-006856-b1w25ob5 1994 12 ) ) -RRB- cord-006856-b1w25ob5 1994 13 and and CC cord-006856-b1w25ob5 1994 14 new new JJ cord-006856-b1w25ob5 1994 15 antiviral antiviral JJ cord-006856-b1w25ob5 1994 16 nucleoside nucleoside NN cord-006856-b1w25ob5 1994 17 analogues analogue NNS cord-006856-b1w25ob5 1994 18 , , , cord-006856-b1w25ob5 1995 1 hepatitis hepatitis NNP cord-006856-b1w25ob5 1995 2 B B NNP cord-006856-b1w25ob5 1995 3 recurrence recurrence NN cord-006856-b1w25ob5 1995 4 was be VBD cord-006856-b1w25ob5 1995 5 seen see VBN cord-006856-b1w25ob5 1995 6 in in IN cord-006856-b1w25ob5 1995 7 the the DT cord-006856-b1w25ob5 1995 8 majority majority NN cord-006856-b1w25ob5 1995 9 of of IN cord-006856-b1w25ob5 1995 10 the the DT cord-006856-b1w25ob5 1995 11 patients patient NNS cord-006856-b1w25ob5 1995 12 resulting result VBG cord-006856-b1w25ob5 1995 13 in in IN cord-006856-b1w25ob5 1995 14 an an DT cord-006856-b1w25ob5 1995 15 inferior inferior JJ cord-006856-b1w25ob5 1995 16 graft graft NN cord-006856-b1w25ob5 1995 17 survival survival NN cord-006856-b1w25ob5 1995 18 . . . cord-006856-b1w25ob5 1996 1 In in IN cord-006856-b1w25ob5 1996 2 this this DT cord-006856-b1w25ob5 1996 3 study study NN cord-006856-b1w25ob5 1996 4 we -PRON- PRP cord-006856-b1w25ob5 1996 5 analyzed analyze VBD cord-006856-b1w25ob5 1996 6 the the DT cord-006856-b1w25ob5 1996 7 different different JJ cord-006856-b1w25ob5 1996 8 clinical clinical JJ cord-006856-b1w25ob5 1996 9 courses course NNS cord-006856-b1w25ob5 1996 10 of of IN cord-006856-b1w25ob5 1996 11 HBV HBV NNP cord-006856-b1w25ob5 1996 12 recurrence recurrence NN cord-006856-b1w25ob5 1996 13 , , , cord-006856-b1w25ob5 1996 14 the the DT cord-006856-b1w25ob5 1996 15 impact impact NN cord-006856-b1w25ob5 1996 16 of of IN cord-006856-b1w25ob5 1996 17 HBV HBV NNP cord-006856-b1w25ob5 1996 18 recurrence recurrence NN cord-006856-b1w25ob5 1996 19 on on IN cord-006856-b1w25ob5 1996 20 patient patient JJ cord-006856-b1w25ob5 1996 21 survival survival NN cord-006856-b1w25ob5 1996 22 , , , cord-006856-b1w25ob5 1996 23 and and CC cord-006856-b1w25ob5 1996 24 potentially potentially RB cord-006856-b1w25ob5 1996 25 contributing contribute VBG cord-006856-b1w25ob5 1996 26 factors factor NNS cord-006856-b1w25ob5 1996 27 for for IN cord-006856-b1w25ob5 1996 28 long long JJ cord-006856-b1w25ob5 1996 29 - - HYPH cord-006856-b1w25ob5 1996 30 term term NN cord-006856-b1w25ob5 1996 31 outcome outcome NN cord-006856-b1w25ob5 1996 32 of of IN cord-006856-b1w25ob5 1996 33 HBV HBV NNP cord-006856-b1w25ob5 1996 34 patients patient NNS cord-006856-b1w25ob5 1996 35 after after IN cord-006856-b1w25ob5 1996 36 LT.Methods lt.method NNS cord-006856-b1w25ob5 1996 37 . . . cord-006856-b1w25ob5 1997 1 Between between IN cord-006856-b1w25ob5 1997 2 1983 1983 CD cord-006856-b1w25ob5 1997 3 and and CC cord-006856-b1w25ob5 1997 4 2003 2003 CD cord-006856-b1w25ob5 1997 5 , , , cord-006856-b1w25ob5 1997 6 57 57 CD cord-006856-b1w25ob5 1997 7 out out IN cord-006856-b1w25ob5 1997 8 of of IN cord-006856-b1w25ob5 1997 9 692 692 CD cord-006856-b1w25ob5 1997 10 patients patient NNS cord-006856-b1w25ob5 1997 11 ( ( -LRB- cord-006856-b1w25ob5 1997 12 50 50 CD cord-006856-b1w25ob5 1997 13 m m NN cord-006856-b1w25ob5 1997 14 , , , cord-006856-b1w25ob5 1997 15 7 7 CD cord-006856-b1w25ob5 1997 16 f f NN cord-006856-b1w25ob5 1997 17 ; ; : cord-006856-b1w25ob5 1997 18 mean mean JJ cord-006856-b1w25ob5 1997 19 age age NN cord-006856-b1w25ob5 1997 20 , , , cord-006856-b1w25ob5 1997 21 51 51 CD cord-006856-b1w25ob5 1997 22 years year NNS cord-006856-b1w25ob5 1997 23 ) ) -RRB- cord-006856-b1w25ob5 1997 24 were be VBD cord-006856-b1w25ob5 1997 25 transplanted transplant VBN cord-006856-b1w25ob5 1997 26 secondary secondary JJ cord-006856-b1w25ob5 1997 27 HBV HBV NNP cord-006856-b1w25ob5 1997 28 cirrhosis cirrhosi NNS cord-006856-b1w25ob5 1997 29 at at IN cord-006856-b1w25ob5 1997 30 our -PRON- PRP$ cord-006856-b1w25ob5 1997 31 center center NN cord-006856-b1w25ob5 1997 32 . . . cord-006856-b1w25ob5 1998 1 The the DT cord-006856-b1w25ob5 1998 2 mean mean JJ cord-006856-b1w25ob5 1998 3 follow follow NN cord-006856-b1w25ob5 1998 4 - - HYPH cord-006856-b1w25ob5 1998 5 up up NN cord-006856-b1w25ob5 1998 6 was be VBD cord-006856-b1w25ob5 1998 7 44 44 CD cord-006856-b1w25ob5 1998 8 months month NNS cord-006856-b1w25ob5 1999 1 ( ( -LRB- cord-006856-b1w25ob5 1999 2 range range NN cord-006856-b1w25ob5 1999 3 , , , cord-006856-b1w25ob5 1999 4 1 1 CD cord-006856-b1w25ob5 1999 5 - - SYM cord-006856-b1w25ob5 1999 6 246 246 CD cord-006856-b1w25ob5 1999 7 months month NNS cord-006856-b1w25ob5 1999 8 ) ) -RRB- cord-006856-b1w25ob5 1999 9 . . . cord-006856-b1w25ob5 2000 1 Immunosuppression Immunosuppression NNP cord-006856-b1w25ob5 2000 2 ( ( -LRB- cord-006856-b1w25ob5 2000 3 IS be VBZ cord-006856-b1w25ob5 2000 4 ) ) -RRB- cord-006856-b1w25ob5 2000 5 consisted consist VBD cord-006856-b1w25ob5 2000 6 of of IN cord-006856-b1w25ob5 2000 7 CyA cya NN cord-006856-b1w25ob5 2000 8 / / SYM cord-006856-b1w25ob5 2000 9 FK FK NNP cord-006856-b1w25ob5 2000 10 506 506 CD cord-006856-b1w25ob5 2000 11 , , , cord-006856-b1w25ob5 2000 12 prednisolone prednisolone NN cord-006856-b1w25ob5 2000 13 and/or and/or CC cord-006856-b1w25ob5 2000 14 azathioprine azathioprine NN cord-006856-b1w25ob5 2000 15 / / SYM cord-006856-b1w25ob5 2000 16 MMF mmf NN cord-006856-b1w25ob5 2000 17 . . . cord-006856-b1w25ob5 2001 1 Fourteen fourteen CD cord-006856-b1w25ob5 2001 2 patients patient NNS cord-006856-b1w25ob5 2001 3 received receive VBD cord-006856-b1w25ob5 2001 4 no no DT cord-006856-b1w25ob5 2001 5 HBIg HBIg NNS cord-006856-b1w25ob5 2001 6 ( ( -LRB- cord-006856-b1w25ob5 2001 7 prior prior RB cord-006856-b1w25ob5 2001 8 to to IN cord-006856-b1w25ob5 2001 9 1993 1993 CD cord-006856-b1w25ob5 2001 10 ) ) -RRB- cord-006856-b1w25ob5 2001 11 , , , cord-006856-b1w25ob5 2001 12 14 14 CD cord-006856-b1w25ob5 2001 13 patients patient NNS cord-006856-b1w25ob5 2001 14 received receive VBD cord-006856-b1w25ob5 2001 15 HBIg HBIg NNS cord-006856-b1w25ob5 2001 16 alone alone RB cord-006856-b1w25ob5 2001 17 , , , cord-006856-b1w25ob5 2001 18 and and CC cord-006856-b1w25ob5 2001 19 29 29 CD cord-006856-b1w25ob5 2001 20 patients patient NNS cord-006856-b1w25ob5 2001 21 HBIg HBIg NNS cord-006856-b1w25ob5 2001 22 in in IN cord-006856-b1w25ob5 2001 23 combination combination NN cord-006856-b1w25ob5 2001 24 with with IN cord-006856-b1w25ob5 2001 25 Lamivudine Lamivudine NNP cord-006856-b1w25ob5 2001 26 ( ( -LRB- cord-006856-b1w25ob5 2001 27 LAM).Results lam).results NN cord-006856-b1w25ob5 2001 28 . . . cord-006856-b1w25ob5 2002 1 The the DT cord-006856-b1w25ob5 2002 2 actuarial actuarial JJ cord-006856-b1w25ob5 2002 3 overall overall JJ cord-006856-b1w25ob5 2002 4 1- 1- CD cord-006856-b1w25ob5 2002 5 , , , cord-006856-b1w25ob5 2002 6 5- 5- NNP cord-006856-b1w25ob5 2002 7 , , , cord-006856-b1w25ob5 2002 8 10-year 10-year CD cord-006856-b1w25ob5 2002 9 survival survival NN cord-006856-b1w25ob5 2002 10 rates rate NNS cord-006856-b1w25ob5 2002 11 were be VBD cord-006856-b1w25ob5 2002 12 83 83 CD cord-006856-b1w25ob5 2002 13 % % NN cord-006856-b1w25ob5 2002 14 , , , cord-006856-b1w25ob5 2002 15 69 69 CD cord-006856-b1w25ob5 2002 16 % % NN cord-006856-b1w25ob5 2002 17 , , , cord-006856-b1w25ob5 2002 18 and and CC cord-006856-b1w25ob5 2002 19 65 65 CD cord-006856-b1w25ob5 2002 20 % % NN cord-006856-b1w25ob5 2002 21 , , , cord-006856-b1w25ob5 2002 22 comparable comparable JJ cord-006856-b1w25ob5 2002 23 to to IN cord-006856-b1w25ob5 2002 24 those those DT cord-006856-b1w25ob5 2002 25 of of IN cord-006856-b1w25ob5 2002 26 other other JJ cord-006856-b1w25ob5 2002 27 indications indication NNS cord-006856-b1w25ob5 2002 28 . . . cord-006856-b1w25ob5 2003 1 Patients patient NNS cord-006856-b1w25ob5 2003 2 with with IN cord-006856-b1w25ob5 2003 3 combined combine VBN cord-006856-b1w25ob5 2003 4 prophylaxis prophylaxis NN cord-006856-b1w25ob5 2003 5 showed show VBD cord-006856-b1w25ob5 2003 6 the the DT cord-006856-b1w25ob5 2003 7 best good JJS cord-006856-b1w25ob5 2003 8 survival survival NN cord-006856-b1w25ob5 2003 9 rates rate NNS cord-006856-b1w25ob5 2003 10 ( ( -LRB- cord-006856-b1w25ob5 2003 11 88 88 CD cord-006856-b1w25ob5 2003 12 % % NN cord-006856-b1w25ob5 2003 13 , , , cord-006856-b1w25ob5 2003 14 77 77 CD cord-006856-b1w25ob5 2003 15 % % NN cord-006856-b1w25ob5 2003 16 , , , cord-006856-b1w25ob5 2003 17 77 77 CD cord-006856-b1w25ob5 2003 18 % % NN cord-006856-b1w25ob5 2003 19 ) ) -RRB- cord-006856-b1w25ob5 2003 20 , , , cord-006856-b1w25ob5 2003 21 compared compare VBN cord-006856-b1w25ob5 2003 22 to to IN cord-006856-b1w25ob5 2003 23 patients patient NNS cord-006856-b1w25ob5 2003 24 treated treat VBN cord-006856-b1w25ob5 2003 25 with with IN cord-006856-b1w25ob5 2003 26 HBIg HBIg NNS cord-006856-b1w25ob5 2003 27 ( ( -LRB- cord-006856-b1w25ob5 2003 28 82 82 CD cord-006856-b1w25ob5 2003 29 % % NN cord-006856-b1w25ob5 2003 30 , , , cord-006856-b1w25ob5 2003 31 51 51 CD cord-006856-b1w25ob5 2003 32 % % NN cord-006856-b1w25ob5 2003 33 , , , cord-006856-b1w25ob5 2003 34 51 51 CD cord-006856-b1w25ob5 2003 35 % % NN cord-006856-b1w25ob5 2003 36 ) ) -RRB- cord-006856-b1w25ob5 2003 37 and and CC cord-006856-b1w25ob5 2003 38 patients patient NNS cord-006856-b1w25ob5 2003 39 without without IN cord-006856-b1w25ob5 2003 40 treatment treatment NN cord-006856-b1w25ob5 2003 41 ( ( -LRB- cord-006856-b1w25ob5 2003 42 76 76 CD cord-006856-b1w25ob5 2003 43 % % NN cord-006856-b1w25ob5 2003 44 , , , cord-006856-b1w25ob5 2003 45 70 70 CD cord-006856-b1w25ob5 2003 46 % % NN cord-006856-b1w25ob5 2003 47 , , , cord-006856-b1w25ob5 2003 48 63 63 CD cord-006856-b1w25ob5 2003 49 % % NN cord-006856-b1w25ob5 2003 50 ) ) -RRB- cord-006856-b1w25ob5 2003 51 . . . cord-006856-b1w25ob5 2004 1 Five five CD cord-006856-b1w25ob5 2004 2 patients patient NNS cord-006856-b1w25ob5 2004 3 required require VBD cord-006856-b1w25ob5 2004 4 ReLTx ReLTx NNP cord-006856-b1w25ob5 2004 5 , , , cord-006856-b1w25ob5 2004 6 one one CD cord-006856-b1w25ob5 2004 7 patient patient JJ cord-006856-b1w25ob5 2004 8 two two CD cord-006856-b1w25ob5 2004 9 ReLTx reltx NN cord-006856-b1w25ob5 2004 10 . . . cord-006856-b1w25ob5 2005 1 In in IN cord-006856-b1w25ob5 2005 2 total total NN cord-006856-b1w25ob5 2005 3 , , , cord-006856-b1w25ob5 2005 4 17 17 CD cord-006856-b1w25ob5 2005 5 patients patient NNS cord-006856-b1w25ob5 2005 6 ( ( -LRB- cord-006856-b1w25ob5 2005 7 33.5 33.5 CD cord-006856-b1w25ob5 2005 8 % % NN cord-006856-b1w25ob5 2005 9 ) ) -RRB- cord-006856-b1w25ob5 2005 10 developed develop VBD cord-006856-b1w25ob5 2005 11 recurrent recurrent JJ cord-006856-b1w25ob5 2005 12 HBV HBV NNP cord-006856-b1w25ob5 2005 13 infection infection NN cord-006856-b1w25ob5 2005 14 after after IN cord-006856-b1w25ob5 2005 15 LT LT NNP cord-006856-b1w25ob5 2005 16 : : : cord-006856-b1w25ob5 2005 17 50 50 CD cord-006856-b1w25ob5 2005 18 % % NN cord-006856-b1w25ob5 2005 19 ( ( -LRB- cord-006856-b1w25ob5 2005 20 6 6 CD cord-006856-b1w25ob5 2005 21 of of IN cord-006856-b1w25ob5 2005 22 12 12 CD cord-006856-b1w25ob5 2005 23 ) ) -RRB- cord-006856-b1w25ob5 2005 24 in in IN cord-006856-b1w25ob5 2005 25 the the DT cord-006856-b1w25ob5 2005 26 non non JJ cord-006856-b1w25ob5 2005 27 - - JJ cord-006856-b1w25ob5 2005 28 HBIg hbig JJ cord-006856-b1w25ob5 2005 29 group group NN cord-006856-b1w25ob5 2005 30 , , , cord-006856-b1w25ob5 2005 31 42 42 CD cord-006856-b1w25ob5 2005 32 % % NN cord-006856-b1w25ob5 2005 33 ( ( -LRB- cord-006856-b1w25ob5 2005 34 6 6 CD cord-006856-b1w25ob5 2005 35 of of IN cord-006856-b1w25ob5 2005 36 14 14 CD cord-006856-b1w25ob5 2005 37 ) ) -RRB- cord-006856-b1w25ob5 2005 38 in in IN cord-006856-b1w25ob5 2005 39 the the DT cord-006856-b1w25ob5 2005 40 HBIg HBIg NNS cord-006856-b1w25ob5 2005 41 mono mono NN cord-006856-b1w25ob5 2005 42 , , , cord-006856-b1w25ob5 2005 43 and and CC cord-006856-b1w25ob5 2005 44 18 18 CD cord-006856-b1w25ob5 2005 45 % % NN cord-006856-b1w25ob5 2005 46 ( ( -LRB- cord-006856-b1w25ob5 2005 47 5 5 CD cord-006856-b1w25ob5 2005 48 of of IN cord-006856-b1w25ob5 2005 49 28 28 CD cord-006856-b1w25ob5 2005 50 ) ) -RRB- cord-006856-b1w25ob5 2005 51 in in IN cord-006856-b1w25ob5 2005 52 the the DT cord-006856-b1w25ob5 2005 53 combined combine VBN cord-006856-b1w25ob5 2005 54 prophylaxis prophylaxis NN cord-006856-b1w25ob5 2005 55 group group NN cord-006856-b1w25ob5 2005 56 . . . cord-006856-b1w25ob5 2006 1 Four four CD cord-006856-b1w25ob5 2006 2 of of IN cord-006856-b1w25ob5 2006 3 the the DT cord-006856-b1w25ob5 2006 4 five five CD cord-006856-b1w25ob5 2006 5 patients patient NNS cord-006856-b1w25ob5 2006 6 in in IN cord-006856-b1w25ob5 2006 7 the the DT cord-006856-b1w25ob5 2006 8 HBIg HBIg NNS cord-006856-b1w25ob5 2006 9 / / SYM cord-006856-b1w25ob5 2006 10 LAM LAM NNP cord-006856-b1w25ob5 2006 11 group group NN cord-006856-b1w25ob5 2006 12 were be VBD cord-006856-b1w25ob5 2006 13 HBV HBV NNP cord-006856-b1w25ob5 2006 14 DNA DNA NNP cord-006856-b1w25ob5 2006 15 positive positive JJ cord-006856-b1w25ob5 2006 16 prior prior RB cord-006856-b1w25ob5 2006 17 to to IN cord-006856-b1w25ob5 2006 18 LT LT NNP cord-006856-b1w25ob5 2006 19 , , , cord-006856-b1w25ob5 2006 20 two two CD cord-006856-b1w25ob5 2006 21 presented present VBN cord-006856-b1w25ob5 2006 22 with with IN cord-006856-b1w25ob5 2006 23 LAM LAM NNP cord-006856-b1w25ob5 2006 24 mutants mutant NNS cord-006856-b1w25ob5 2006 25 . . . cord-006856-b1w25ob5 2007 1 HBV hbv NN cord-006856-b1w25ob5 2007 2 recurrence recurrence NN cord-006856-b1w25ob5 2007 3 , , , cord-006856-b1w25ob5 2007 4 however however RB cord-006856-b1w25ob5 2007 5 , , , cord-006856-b1w25ob5 2007 6 did do VBD cord-006856-b1w25ob5 2007 7 not not RB cord-006856-b1w25ob5 2007 8 negatively negatively RB cord-006856-b1w25ob5 2007 9 impact impact VB cord-006856-b1w25ob5 2007 10 patient patient NN cord-006856-b1w25ob5 2007 11 outcome outcome NN cord-006856-b1w25ob5 2007 12 . . . cord-006856-b1w25ob5 2008 1 All all DT cord-006856-b1w25ob5 2008 2 patients patient NNS cord-006856-b1w25ob5 2008 3 with with IN cord-006856-b1w25ob5 2008 4 recurrent recurrent JJ cord-006856-b1w25ob5 2008 5 disease disease NN cord-006856-b1w25ob5 2008 6 were be VBD cord-006856-b1w25ob5 2008 7 treated treat VBN cord-006856-b1w25ob5 2008 8 with with IN cord-006856-b1w25ob5 2008 9 antivirals antiviral NNS cord-006856-b1w25ob5 2008 10 ( ( -LRB- cord-006856-b1w25ob5 2008 11 Famcyclovir Famcyclovir NNP cord-006856-b1w25ob5 2008 12 , , , cord-006856-b1w25ob5 2008 13 LAM LAM NNP cord-006856-b1w25ob5 2008 14 , , , cord-006856-b1w25ob5 2008 15 Adefovir Adefovir NNP cord-006856-b1w25ob5 2008 16 ) ) -RRB- cord-006856-b1w25ob5 2008 17 . . . cord-006856-b1w25ob5 2009 1 Forty forty CD cord-006856-b1w25ob5 2009 2 - - HYPH cord-006856-b1w25ob5 2009 3 seven seven CD cord-006856-b1w25ob5 2009 4 percent percent NN cord-006856-b1w25ob5 2009 5 of of IN cord-006856-b1w25ob5 2009 6 patients patient NNS cord-006856-b1w25ob5 2009 7 responded respond VBD cord-006856-b1w25ob5 2009 8 to to IN cord-006856-b1w25ob5 2009 9 the the DT cord-006856-b1w25ob5 2009 10 treatment treatment NN cord-006856-b1w25ob5 2009 11 and and CC cord-006856-b1w25ob5 2009 12 remained remain VBD cord-006856-b1w25ob5 2009 13 HBV HBV NNP cord-006856-b1w25ob5 2009 14 DNA DNA NNP cord-006856-b1w25ob5 2009 15 negative negative JJ cord-006856-b1w25ob5 2009 16 . . . cord-006856-b1w25ob5 2010 1 Only only RB cord-006856-b1w25ob5 2010 2 one one CD cord-006856-b1w25ob5 2010 3 patient patient NN cord-006856-b1w25ob5 2010 4 was be VBD cord-006856-b1w25ob5 2010 5 retransplantated retransplantate VBN cord-006856-b1w25ob5 2010 6 due due IN cord-006856-b1w25ob5 2010 7 to to IN cord-006856-b1w25ob5 2010 8 HBV HBV NNP cord-006856-b1w25ob5 2010 9 recurrence recurrence NN cord-006856-b1w25ob5 2010 10 . . . cord-006856-b1w25ob5 2011 1 No no DT cord-006856-b1w25ob5 2011 2 possible possible JJ cord-006856-b1w25ob5 2011 3 risk risk NN cord-006856-b1w25ob5 2011 4 factors factor NNS cord-006856-b1w25ob5 2011 5 for for IN cord-006856-b1w25ob5 2011 6 overall overall JJ cord-006856-b1w25ob5 2011 7 survival survival NN cord-006856-b1w25ob5 2011 8 were be VBD cord-006856-b1w25ob5 2011 9 found find VBN cord-006856-b1w25ob5 2011 10 to to TO cord-006856-b1w25ob5 2011 11 be be VB cord-006856-b1w25ob5 2011 12 significant significant JJ cord-006856-b1w25ob5 2011 13 . . . cord-006856-b1w25ob5 2012 1 Conclusions conclusion NNS cord-006856-b1w25ob5 2012 2 . . . cord-006856-b1w25ob5 2013 1 Our -PRON- PRP$ cord-006856-b1w25ob5 2013 2 study study NN cord-006856-b1w25ob5 2013 3 showed show VBD cord-006856-b1w25ob5 2013 4 that that IN cord-006856-b1w25ob5 2013 5 patients patient NNS cord-006856-b1w25ob5 2013 6 with with IN cord-006856-b1w25ob5 2013 7 combined combined JJ cord-006856-b1w25ob5 2013 8 HBIg HBIg NNS cord-006856-b1w25ob5 2013 9 / / SYM cord-006856-b1w25ob5 2013 10 LAM LAM NNP cord-006856-b1w25ob5 2013 11 prophylaxis prophylaxis NN cord-006856-b1w25ob5 2013 12 had have VBD cord-006856-b1w25ob5 2013 13 excellent excellent JJ cord-006856-b1w25ob5 2013 14 long long JJ cord-006856-b1w25ob5 2013 15 - - HYPH cord-006856-b1w25ob5 2013 16 term term NN cord-006856-b1w25ob5 2013 17 survival survival NN cord-006856-b1w25ob5 2013 18 . . . cord-006856-b1w25ob5 2014 1 Recurrent recurrent JJ cord-006856-b1w25ob5 2014 2 HBV HBV NNP cord-006856-b1w25ob5 2014 3 in in IN cord-006856-b1w25ob5 2014 4 the the DT cord-006856-b1w25ob5 2014 5 allograft allograft NN cord-006856-b1w25ob5 2014 6 could could MD cord-006856-b1w25ob5 2014 7 be be VB cord-006856-b1w25ob5 2014 8 effectively effectively RB cord-006856-b1w25ob5 2014 9 treated treat VBN cord-006856-b1w25ob5 2014 10 in in IN cord-006856-b1w25ob5 2014 11 the the DT cord-006856-b1w25ob5 2014 12 majority majority NN cord-006856-b1w25ob5 2014 13 of of IN cord-006856-b1w25ob5 2014 14 patients patient NNS cord-006856-b1w25ob5 2014 15 and and CC cord-006856-b1w25ob5 2014 16 did do VBD cord-006856-b1w25ob5 2014 17 not not RB cord-006856-b1w25ob5 2014 18 influence influence VB cord-006856-b1w25ob5 2014 19 longterm longterm JJ cord-006856-b1w25ob5 2014 20 survival survival NN cord-006856-b1w25ob5 2014 21 . . . cord-006856-b1w25ob5 2015 1 Background background NN cord-006856-b1w25ob5 2015 2 . . . cord-006856-b1w25ob5 2016 1 Liver liver NN cord-006856-b1w25ob5 2016 2 failure failure NN cord-006856-b1w25ob5 2016 3 is be VBZ cord-006856-b1w25ob5 2016 4 associated associate VBN cord-006856-b1w25ob5 2016 5 with with IN cord-006856-b1w25ob5 2016 6 reduced reduce VBN cord-006856-b1w25ob5 2016 7 synthesis synthesis NN cord-006856-b1w25ob5 2016 8 of of IN cord-006856-b1w25ob5 2016 9 clotting clotting NN cord-006856-b1w25ob5 2016 10 factors factor NNS cord-006856-b1w25ob5 2016 11 , , , cord-006856-b1w25ob5 2016 12 consumptive consumptive JJ cord-006856-b1w25ob5 2016 13 coagulopathy coagulopathy NN cord-006856-b1w25ob5 2016 14 , , , cord-006856-b1w25ob5 2016 15 and and CC cord-006856-b1w25ob5 2016 16 platelet platelet NN cord-006856-b1w25ob5 2016 17 dysfunction dysfunction NN cord-006856-b1w25ob5 2016 18 . . . cord-006856-b1w25ob5 2017 1 The the DT cord-006856-b1w25ob5 2017 2 aim aim NN cord-006856-b1w25ob5 2017 3 of of IN cord-006856-b1w25ob5 2017 4 the the DT cord-006856-b1w25ob5 2017 5 study study NN cord-006856-b1w25ob5 2017 6 was be VBD cord-006856-b1w25ob5 2017 7 to to TO cord-006856-b1w25ob5 2017 8 evaluate evaluate VB cord-006856-b1w25ob5 2017 9 the the DT cord-006856-b1w25ob5 2017 10 effects effect NNS cord-006856-b1w25ob5 2017 11 of of IN cord-006856-b1w25ob5 2017 12 liver liver NN cord-006856-b1w25ob5 2017 13 support support NN cord-006856-b1w25ob5 2017 14 using use VBG cord-006856-b1w25ob5 2017 15 the the DT cord-006856-b1w25ob5 2017 16 molecular molecular JJ cord-006856-b1w25ob5 2017 17 adsorbent adsorbent NN cord-006856-b1w25ob5 2017 18 recirculating recirculate VBG cord-006856-b1w25ob5 2017 19 system system NN cord-006856-b1w25ob5 2017 20 ( ( -LRB- cord-006856-b1w25ob5 2017 21 MARS MARS NNP cord-006856-b1w25ob5 2017 22 ) ) -RRB- cord-006856-b1w25ob5 2017 23 on on IN cord-006856-b1w25ob5 2017 24 the the DT cord-006856-b1w25ob5 2017 25 coagulation coagulation NN cord-006856-b1w25ob5 2017 26 system system NN cord-006856-b1w25ob5 2017 27 in in IN cord-006856-b1w25ob5 2017 28 patients patient NNS cord-006856-b1w25ob5 2017 29 at at IN cord-006856-b1w25ob5 2017 30 high high JJ cord-006856-b1w25ob5 2017 31 risk risk NN cord-006856-b1w25ob5 2017 32 of of IN cord-006856-b1w25ob5 2017 33 bleeding bleed VBG cord-006856-b1w25ob5 2017 34 . . . cord-006856-b1w25ob5 2018 1 Methods method NNS cord-006856-b1w25ob5 2018 2 . . . cord-006856-b1w25ob5 2019 1 61 61 CD cord-006856-b1w25ob5 2019 2 MARS MARS NNP cord-006856-b1w25ob5 2019 3 treatments treatment NNS cord-006856-b1w25ob5 2019 4 in in IN cord-006856-b1w25ob5 2019 5 33 33 CD cord-006856-b1w25ob5 2019 6 patients patient NNS cord-006856-b1w25ob5 2019 7 with with IN cord-006856-b1w25ob5 2019 8 acute acute JJ cord-006856-b1w25ob5 2019 9 liver liver NN cord-006856-b1w25ob5 2019 10 failure failure NN cord-006856-b1w25ob5 2019 11 ( ( -LRB- cord-006856-b1w25ob5 2019 12 n n NN cord-006856-b1w25ob5 2019 13 = = SYM cord-006856-b1w25ob5 2019 14 15 15 CD cord-006856-b1w25ob5 2019 15 ) ) -RRB- cord-006856-b1w25ob5 2019 16 , , , cord-006856-b1w25ob5 2019 17 acute acute JJ cord-006856-b1w25ob5 2019 18 on on IN cord-006856-b1w25ob5 2019 19 chronic chronic JJ cord-006856-b1w25ob5 2019 20 liver liver NN cord-006856-b1w25ob5 2019 21 failure failure NN cord-006856-b1w25ob5 2019 22 ( ( -LRB- cord-006856-b1w25ob5 2019 23 n n NN cord-006856-b1w25ob5 2019 24 = = SYM cord-006856-b1w25ob5 2019 25 8) 8) NN cord-006856-b1w25ob5 2019 26 , , , cord-006856-b1w25ob5 2019 27 sepsis sepsis NN cord-006856-b1w25ob5 2019 28 ( ( -LRB- cord-006856-b1w25ob5 2019 29 n n NN cord-006856-b1w25ob5 2019 30 = = SYM cord-006856-b1w25ob5 2019 31 5 5 CD cord-006856-b1w25ob5 2019 32 ) ) -RRB- cord-006856-b1w25ob5 2019 33 , , , cord-006856-b1w25ob5 2019 34 liver liver NN cord-006856-b1w25ob5 2019 35 graft graft NN cord-006856-b1w25ob5 2019 36 dysfunction dysfunction NN cord-006856-b1w25ob5 2019 37 ( ( -LRB- cord-006856-b1w25ob5 2019 38 n n NN cord-006856-b1w25ob5 2019 39 = = SYM cord-006856-b1w25ob5 2019 40 3 3 CD cord-006856-b1w25ob5 2019 41 ) ) -RRB- cord-006856-b1w25ob5 2019 42 , , , cord-006856-b1w25ob5 2019 43 and and CC cord-006856-b1w25ob5 2019 44 cholestasis cholestasis NN cord-006856-b1w25ob5 2019 45 ( ( -LRB- cord-006856-b1w25ob5 2019 46 n n NN cord-006856-b1w25ob5 2019 47 = = SYM cord-006856-b1w25ob5 2019 48 2 2 CD cord-006856-b1w25ob5 2019 49 ) ) -RRB- cord-006856-b1w25ob5 2019 50 have have VBP cord-006856-b1w25ob5 2019 51 been be VBN cord-006856-b1w25ob5 2019 52 studied study VBN cord-006856-b1w25ob5 2019 53 . . . cord-006856-b1w25ob5 2020 1 Standard standard JJ cord-006856-b1w25ob5 2020 2 coagulation coagulation NN cord-006856-b1w25ob5 2020 3 tests test NNS cord-006856-b1w25ob5 2020 4 , , , cord-006856-b1w25ob5 2020 5 standard standard JJ cord-006856-b1w25ob5 2020 6 thromboelastography thromboelastography NNP cord-006856-b1w25ob5 2020 7 ( ( -LRB- cord-006856-b1w25ob5 2020 8 TEG TEG NNP cord-006856-b1w25ob5 2020 9 ) ) -RRB- cord-006856-b1w25ob5 2020 10 , , , cord-006856-b1w25ob5 2020 11 heparinase heparinase NN cord-006856-b1w25ob5 2020 12 - - HYPH cord-006856-b1w25ob5 2020 13 modified modify VBN cord-006856-b1w25ob5 2020 14 and and CC cord-006856-b1w25ob5 2020 15 abciximab abciximab JJ cord-006856-b1w25ob5 2020 16 - - HYPH cord-006856-b1w25ob5 2020 17 fab fab JJ cord-006856-b1w25ob5 2020 18 - - HYPH cord-006856-b1w25ob5 2020 19 modified modify VBN cord-006856-b1w25ob5 2020 20 TEG TEG NNP cord-006856-b1w25ob5 2020 21 were be VBD cord-006856-b1w25ob5 2020 22 performed perform VBN cord-006856-b1w25ob5 2020 23 immediately immediately RB cord-006856-b1w25ob5 2020 24 before before IN cord-006856-b1w25ob5 2020 25 and and CC cord-006856-b1w25ob5 2020 26 30 30 CD cord-006856-b1w25ob5 2020 27 minutes minute NNS cord-006856-b1w25ob5 2020 28 after after IN cord-006856-b1w25ob5 2020 29 commencement commencement NN cord-006856-b1w25ob5 2020 30 of of IN cord-006856-b1w25ob5 2020 31 MARS MARS NNP cord-006856-b1w25ob5 2020 32 and and CC cord-006856-b1w25ob5 2020 33 after after IN cord-006856-b1w25ob5 2020 34 the the DT cord-006856-b1w25ob5 2020 35 end end NN cord-006856-b1w25ob5 2020 36 of of IN cord-006856-b1w25ob5 2020 37 MARS MARS NNP cord-006856-b1w25ob5 2020 38 treatment treatment NN cord-006856-b1w25ob5 2020 39 . . . cord-006856-b1w25ob5 2021 1 To to IN cord-006856-b1w25ob5 2021 2 all all DT cord-006856-b1w25ob5 2021 3 patients patient NNS cord-006856-b1w25ob5 2021 4 , , , cord-006856-b1w25ob5 2021 5 prostaglandin prostaglandin NN cord-006856-b1w25ob5 2021 6 I2 i2 NN cord-006856-b1w25ob5 2021 7 was be VBD cord-006856-b1w25ob5 2021 8 administered administer VBN cord-006856-b1w25ob5 2021 9 extracorporeally extracorporeally RB cord-006856-b1w25ob5 2021 10 . . . cord-006856-b1w25ob5 2022 1 17 17 CD cord-006856-b1w25ob5 2022 2 patients patient NNS cord-006856-b1w25ob5 2022 3 additionally additionally RB cord-006856-b1w25ob5 2022 4 received receive VBD cord-006856-b1w25ob5 2022 5 unfractioned unfractioned JJ cord-006856-b1w25ob5 2022 6 heparin heparin NN cord-006856-b1w25ob5 2022 7 . . . cord-006856-b1w25ob5 2023 1 Results result NNS cord-006856-b1w25ob5 2023 2 . . . cord-006856-b1w25ob5 2024 1 Three three CD cord-006856-b1w25ob5 2024 2 moderate moderate JJ cord-006856-b1w25ob5 2024 3 bleeding bleed VBG cord-006856-b1w25ob5 2024 4 complications complication NNS cord-006856-b1w25ob5 2024 5 in in IN cord-006856-b1w25ob5 2024 6 three three CD cord-006856-b1w25ob5 2024 7 patients patient NNS cord-006856-b1w25ob5 2024 8 , , , cord-006856-b1w25ob5 2024 9 requiring require VBG cord-006856-b1w25ob5 2024 10 3 3 CD cord-006856-b1w25ob5 2024 11 - - SYM cord-006856-b1w25ob5 2024 12 4 4 CD cord-006856-b1w25ob5 2024 13 units unit NNS cord-006856-b1w25ob5 2024 14 of of IN cord-006856-b1w25ob5 2024 15 packed packed JJ cord-006856-b1w25ob5 2024 16 red red JJ cord-006856-b1w25ob5 2024 17 blood blood NN cord-006856-b1w25ob5 2024 18 cells cell NNS cord-006856-b1w25ob5 2024 19 , , , cord-006856-b1w25ob5 2024 20 were be VBD cord-006856-b1w25ob5 2024 21 observed observe VBN cord-006856-b1w25ob5 2024 22 . . . cord-006856-b1w25ob5 2025 1 All all DT cord-006856-b1w25ob5 2025 2 were be VBD cord-006856-b1w25ob5 2025 3 sufficiently sufficiently RB cord-006856-b1w25ob5 2025 4 managed manage VBN cord-006856-b1w25ob5 2025 5 without without IN cord-006856-b1w25ob5 2025 6 interrupting interrupt VBG cord-006856-b1w25ob5 2025 7 MARS MARS NNP cord-006856-b1w25ob5 2025 8 treatment treatment NN cord-006856-b1w25ob5 2025 9 . . . cord-006856-b1w25ob5 2026 1 Although although IN cord-006856-b1w25ob5 2026 2 there there EX cord-006856-b1w25ob5 2026 3 was be VBD cord-006856-b1w25ob5 2026 4 a a DT cord-006856-b1w25ob5 2026 5 significant significant JJ cord-006856-b1w25ob5 2026 6 decrease decrease NN cord-006856-b1w25ob5 2026 7 in in IN cord-006856-b1w25ob5 2026 8 platelet platelet NN cord-006856-b1w25ob5 2026 9 counts count NNS cord-006856-b1w25ob5 2026 10 ( ( -LRB- cord-006856-b1w25ob5 2026 11 median median NN cord-006856-b1w25ob5 2026 12 , , , cord-006856-b1w25ob5 2026 13 9 9 CD cord-006856-b1w25ob5 2026 14 G g NN cord-006856-b1w25ob5 2026 15 / / SYM cord-006856-b1w25ob5 2026 16 l l NN cord-006856-b1w25ob5 2026 17 ; ; : cord-006856-b1w25ob5 2026 18 range range NN cord-006856-b1w25ob5 2026 19 , , , cord-006856-b1w25ob5 2026 20 -40 -40 NN cord-006856-b1w25ob5 2026 21 to to IN cord-006856-b1w25ob5 2026 22 145 145 CD cord-006856-b1w25ob5 2026 23 G g NN cord-006856-b1w25ob5 2026 24 / / SYM cord-006856-b1w25ob5 2026 25 l l NN cord-006856-b1w25ob5 2026 26 ) ) -RRB- cord-006856-b1w25ob5 2026 27 and and CC cord-006856-b1w25ob5 2026 28 fibrinogen fibrinogen NN cord-006856-b1w25ob5 2026 29 concentration concentration NN cord-006856-b1w25ob5 2026 30 ( ( -LRB- cord-006856-b1w25ob5 2026 31 median median NN cord-006856-b1w25ob5 2026 32 , , , cord-006856-b1w25ob5 2026 33 15 15 CD cord-006856-b1w25ob5 2026 34 mg mg NNP cord-006856-b1w25ob5 2026 35 / / SYM cord-006856-b1w25ob5 2026 36 dl dl NN cord-006856-b1w25ob5 2026 37 ; ; : cord-006856-b1w25ob5 2026 38 range range NN cord-006856-b1w25ob5 2026 39 , , , cord-006856-b1w25ob5 2026 40 -119 -119 FW cord-006856-b1w25ob5 2027 1 to to IN cord-006856-b1w25ob5 2027 2 185 185 CD cord-006856-b1w25ob5 2027 3 mg mg NNP cord-006856-b1w25ob5 2027 4 / / SYM cord-006856-b1w25ob5 2027 5 dl dl NNP cord-006856-b1w25ob5 2027 6 ) ) -RRB- cord-006856-b1w25ob5 2027 7 with with IN cord-006856-b1w25ob5 2027 8 a a DT cord-006856-b1w25ob5 2027 9 consecutive consecutive JJ cord-006856-b1w25ob5 2027 10 increase increase NN cord-006856-b1w25ob5 2027 11 in in IN cord-006856-b1w25ob5 2027 12 thrombin thrombin JJ cord-006856-b1w25ob5 2027 13 time time NN cord-006856-b1w25ob5 2027 14 , , , cord-006856-b1w25ob5 2027 15 the the DT cord-006856-b1w25ob5 2027 16 platelet platelet NN cord-006856-b1w25ob5 2027 17 function function NN cord-006856-b1w25ob5 2027 18 , , , cord-006856-b1w25ob5 2027 19 as as IN cord-006856-b1w25ob5 2027 20 assessed assess VBN cord-006856-b1w25ob5 2027 21 by by IN cord-006856-b1w25ob5 2027 22 abciximab abciximab JJ cord-006856-b1w25ob5 2027 23 - - HYPH cord-006856-b1w25ob5 2027 24 fab fab JJ cord-006856-b1w25ob5 2027 25 - - HYPH cord-006856-b1w25ob5 2027 26 modified modify VBN cord-006856-b1w25ob5 2027 27 TEG TEG NNP cord-006856-b1w25ob5 2027 28 , , , cord-006856-b1w25ob5 2027 29 remained remain VBD cord-006856-b1w25ob5 2027 30 stable stable JJ cord-006856-b1w25ob5 2027 31 . . . cord-006856-b1w25ob5 2028 1 MARS MARS NNP cord-006856-b1w25ob5 2028 2 did do VBD cord-006856-b1w25ob5 2028 3 not not RB cord-006856-b1w25ob5 2028 4 enhance enhance VB cord-006856-b1w25ob5 2028 5 fibrinolysis fibrinolysis NN cord-006856-b1w25ob5 2028 6 . . . cord-006856-b1w25ob5 2029 1 Conclusions conclusion NNS cord-006856-b1w25ob5 2029 2 . . . cord-006856-b1w25ob5 2030 1 MARS MARS NNP cord-006856-b1w25ob5 2030 2 treatment treatment NN cord-006856-b1w25ob5 2030 3 appears appear VBZ cord-006856-b1w25ob5 2030 4 to to TO cord-006856-b1w25ob5 2030 5 be be VB cord-006856-b1w25ob5 2030 6 well well RB cord-006856-b1w25ob5 2030 7 tolerated tolerate VBN cord-006856-b1w25ob5 2030 8 in in IN cord-006856-b1w25ob5 2030 9 patients patient NNS cord-006856-b1w25ob5 2030 10 with with IN cord-006856-b1w25ob5 2030 11 marked marked JJ cord-006856-b1w25ob5 2030 12 coagulopathy coagulopathy NN cord-006856-b1w25ob5 2030 13 due due IN cord-006856-b1w25ob5 2030 14 to to IN cord-006856-b1w25ob5 2030 15 liver liver NN cord-006856-b1w25ob5 2030 16 failure failure NN cord-006856-b1w25ob5 2030 17 . . . cord-006856-b1w25ob5 2031 1 Although although IN cord-006856-b1w25ob5 2031 2 MARS MARS NNP cord-006856-b1w25ob5 2031 3 leads lead VBZ cord-006856-b1w25ob5 2031 4 to to IN cord-006856-b1w25ob5 2031 5 a a DT cord-006856-b1w25ob5 2031 6 further further JJ cord-006856-b1w25ob5 2031 7 decrease decrease NN cord-006856-b1w25ob5 2031 8 in in IN cord-006856-b1w25ob5 2031 9 platelet platelet NN cord-006856-b1w25ob5 2031 10 count count NN cord-006856-b1w25ob5 2031 11 and and CC cord-006856-b1w25ob5 2031 12 fibrinogen fibrinogen NN cord-006856-b1w25ob5 2031 13 concentration concentration NN cord-006856-b1w25ob5 2031 14 , , , cord-006856-b1w25ob5 2031 15 platelet platelet NN cord-006856-b1w25ob5 2031 16 function function NN cord-006856-b1w25ob5 2031 17 , , , cord-006856-b1w25ob5 2031 18 measured measure VBN cord-006856-b1w25ob5 2031 19 as as IN cord-006856-b1w25ob5 2031 20 contribution contribution NN cord-006856-b1w25ob5 2031 21 of of IN cord-006856-b1w25ob5 2031 22 the the DT cord-006856-b1w25ob5 2031 23 platelets platelet NNS cord-006856-b1w25ob5 2031 24 to to IN cord-006856-b1w25ob5 2031 25 the the DT cord-006856-b1w25ob5 2031 26 clot clot NN cord-006856-b1w25ob5 2031 27 firmness firmness NN cord-006856-b1w25ob5 2031 28 in in IN cord-006856-b1w25ob5 2031 29 TEG TEG NNP cord-006856-b1w25ob5 2031 30 , , , cord-006856-b1w25ob5 2031 31 remains remain VBZ cord-006856-b1w25ob5 2031 32 stable stable JJ cord-006856-b1w25ob5 2031 33 . . . cord-006856-b1w25ob5 2032 1 According accord VBG cord-006856-b1w25ob5 2032 2 to to IN cord-006856-b1w25ob5 2032 3 TEG TEG NNP cord-006856-b1w25ob5 2032 4 - - HYPH cord-006856-b1w25ob5 2032 5 based base VBN cord-006856-b1w25ob5 2032 6 results result NNS cord-006856-b1w25ob5 2032 7 , , , cord-006856-b1w25ob5 2032 8 MARS MARS NNP cord-006856-b1w25ob5 2032 9 does do VBZ cord-006856-b1w25ob5 2032 10 not not RB cord-006856-b1w25ob5 2032 11 enhance enhance VB cord-006856-b1w25ob5 2032 12 fibrinolysis fibrinolysis NN cord-006856-b1w25ob5 2032 13 . . . cord-006856-b1w25ob5 2033 1 Methodik Methodik NNP cord-006856-b1w25ob5 2033 2 . . . cord-006856-b1w25ob5 2034 1 Ein Ein NNP cord-006856-b1w25ob5 2034 2 69 69 CD cord-006856-b1w25ob5 2034 3 Jahre Jahre NNP cord-006856-b1w25ob5 2034 4 alter alter VB cord-006856-b1w25ob5 2034 5 Patient Patient NNP cord-006856-b1w25ob5 2034 6 war war NN cord-006856-b1w25ob5 2034 7 vor vor NN cord-006856-b1w25ob5 2035 1 13 13 CD cord-006856-b1w25ob5 2035 2 Jahren Jahren NNP cord-006856-b1w25ob5 2035 3 aufgrund aufgrund NNP cord-006856-b1w25ob5 2035 4 einer einer NNP cord-006856-b1w25ob5 2035 5 post post JJ cord-006856-b1w25ob5 2035 6 - - JJ cord-006856-b1w25ob5 2035 7 hepatitischen hepatitischen JJ cord-006856-b1w25ob5 2035 8 Zirrhose Zirrhose NNP cord-006856-b1w25ob5 2035 9 ( ( -LRB- cord-006856-b1w25ob5 2035 10 PHCC PHCC NNP cord-006856-b1w25ob5 2035 11 ) ) -RRB- cord-006856-b1w25ob5 2035 12 lebertransplantiert lebertransplantiert NNP cord-006856-b1w25ob5 2035 13 worden worden NNP cord-006856-b1w25ob5 2035 14 . . . cord-006856-b1w25ob5 2036 1 Nun Nun NNP cord-006856-b1w25ob5 2036 2 war war NN cord-006856-b1w25ob5 2037 1 es es XX cord-006856-b1w25ob5 2038 1 i -PRON- PRP cord-006856-b1w25ob5 2038 2 m be VBP cord-006856-b1w25ob5 2038 3 Verlauf Verlauf NNP cord-006856-b1w25ob5 2038 4 der der NNP cord-006856-b1w25ob5 2038 5 letzten letzten FW cord-006856-b1w25ob5 2038 6 Zeit Zeit NNP cord-006856-b1w25ob5 2038 7 zu zu NNP cord-006856-b1w25ob5 2038 8 einer einer NNP cord-006856-b1w25ob5 2038 9 deutlichen deutlichen NNP cord-006856-b1w25ob5 2038 10 Gewichtszunahme Gewichtszunahme NNP cord-006856-b1w25ob5 2038 11 gekommen gekommen NNP cord-006856-b1w25ob5 2038 12 , , , cord-006856-b1w25ob5 2038 13 sodass sodass NNP cord-006856-b1w25ob5 2038 14 der der NN cord-006856-b1w25ob5 2038 15 Pati- Pati- NNP