id sid tid token lemma pos cord-007788-09t52zix 1 1 key key JJ cord-007788-09t52zix 2 1 : : : cord-007788-09t52zix 2 2 cord-007788 cord-007788 VB cord-007788-09t52zix 2 3 - - HYPH cord-007788-09t52zix 2 4 09t52zix 09t52zix CD cord-007788-09t52zix 2 5 authors author NNS cord-007788-09t52zix 2 6 : : : cord-007788-09t52zix 2 7 Wallhult Wallhult NNP cord-007788-09t52zix 2 8 , , , cord-007788-09t52zix 2 9 Elisabeth Elisabeth NNP cord-007788-09t52zix 2 10 ; ; : cord-007788-09t52zix 2 11 Quinn Quinn NNP cord-007788-09t52zix 2 12 , , , cord-007788-09t52zix 2 13 Barry Barry NNP cord-007788-09t52zix 2 14 title title NN cord-007788-09t52zix 2 15 : : : cord-007788-09t52zix 2 16 Early early JJ cord-007788-09t52zix 2 17 and and CC cord-007788-09t52zix 2 18 Acute Acute NNP cord-007788-09t52zix 2 19 Complications Complications NNPS cord-007788-09t52zix 2 20 and and CC cord-007788-09t52zix 2 21 the the DT cord-007788-09t52zix 2 22 Principles Principles NNPS cord-007788-09t52zix 2 23 of of IN cord-007788-09t52zix 2 24 HSCT HSCT NNP cord-007788-09t52zix 2 25 Nursing Nursing NNP cord-007788-09t52zix 2 26 Care Care NNP cord-007788-09t52zix 2 27 date date NN cord-007788-09t52zix 2 28 : : : cord-007788-09t52zix 2 29 2017 2017 CD cord-007788-09t52zix 2 30 - - HYPH cord-007788-09t52zix 2 31 11 11 CD cord-007788-09t52zix 2 32 - - SYM cord-007788-09t52zix 2 33 22 22 CD cord-007788-09t52zix 2 34 journal journal NN cord-007788-09t52zix 2 35 : : : cord-007788-09t52zix 2 36 The the DT cord-007788-09t52zix 2 37 European European NNP cord-007788-09t52zix 2 38 Blood Blood NNP cord-007788-09t52zix 2 39 and and CC cord-007788-09t52zix 2 40 Marrow Marrow NNP cord-007788-09t52zix 2 41 Transplantation Transplantation NNP cord-007788-09t52zix 2 42 Textbook Textbook NNP cord-007788-09t52zix 2 43 for for IN cord-007788-09t52zix 2 44 Nurses Nurses NNP cord-007788-09t52zix 2 45 DOI DOI NNP cord-007788-09t52zix 2 46 : : : cord-007788-09t52zix 2 47 10.1007/978 10.1007/978 CD cord-007788-09t52zix 2 48 - - HYPH cord-007788-09t52zix 2 49 3 3 CD cord-007788-09t52zix 2 50 - - HYPH cord-007788-09t52zix 2 51 319 319 CD cord-007788-09t52zix 2 52 - - HYPH cord-007788-09t52zix 2 53 50026 50026 CD cord-007788-09t52zix 2 54 - - HYPH cord-007788-09t52zix 2 55 3_9 3_9 CD cord-007788-09t52zix 2 56 sha sha NNP cord-007788-09t52zix 2 57 : : : cord-007788-09t52zix 3 1 114a61f92c237414dfcb8e5052e4a90954515e4c 114a61f92c237414dfcb8e5052e4a90954515e4c NNP cord-007788-09t52zix 3 2 doc_id doc_id NNP cord-007788-09t52zix 3 3 : : : cord-007788-09t52zix 3 4 7788 7788 CD cord-007788-09t52zix 3 5 cord_uid cord_uid NNS cord-007788-09t52zix 3 6 : : : cord-007788-09t52zix 3 7 09t52zix 09t52zix CD cord-007788-09t52zix 4 1 Haematopoietic haematopoietic JJ cord-007788-09t52zix 4 2 stem stem NN cord-007788-09t52zix 4 3 cell cell NN cord-007788-09t52zix 4 4 transplantation transplantation NN cord-007788-09t52zix 4 5 ( ( -LRB- cord-007788-09t52zix 4 6 HSCT HSCT NNP cord-007788-09t52zix 4 7 ) ) -RRB- cord-007788-09t52zix 4 8 generally generally RB cord-007788-09t52zix 4 9 includes include VBZ cord-007788-09t52zix 4 10 preparative preparative JJ cord-007788-09t52zix 4 11 or or CC cord-007788-09t52zix 4 12 conditioning conditioning NN cord-007788-09t52zix 4 13 regimes regime NNS cord-007788-09t52zix 4 14 containing contain VBG cord-007788-09t52zix 4 15 chemotherapy chemotherapy NN cord-007788-09t52zix 4 16 and/or and/or CC cord-007788-09t52zix 4 17 radiotherapy radiotherapy NN cord-007788-09t52zix 4 18 in in IN cord-007788-09t52zix 4 19 high high JJ cord-007788-09t52zix 4 20 doses dose NNS cord-007788-09t52zix 4 21 . . . cord-007788-09t52zix 5 1 These these DT cord-007788-09t52zix 5 2 regimens regimen NNS cord-007788-09t52zix 5 3 , , , cord-007788-09t52zix 5 4 as as RB cord-007788-09t52zix 5 5 well well RB cord-007788-09t52zix 5 6 as as IN cord-007788-09t52zix 5 7 other other JJ cord-007788-09t52zix 5 8 treatments treatment NNS cord-007788-09t52zix 5 9 before before IN cord-007788-09t52zix 5 10 and and CC cord-007788-09t52zix 5 11 after after IN cord-007788-09t52zix 5 12 HSCT HSCT NNP cord-007788-09t52zix 5 13 such such JJ cord-007788-09t52zix 5 14 as as IN cord-007788-09t52zix 5 15 immunosuppressive immunosuppressive JJ cord-007788-09t52zix 5 16 drugs drug NNS cord-007788-09t52zix 5 17 to to TO cord-007788-09t52zix 5 18 prevent prevent VB cord-007788-09t52zix 5 19 graft graft NN cord-007788-09t52zix 5 20 versus versus IN cord-007788-09t52zix 5 21 host host NN cord-007788-09t52zix 5 22 disease disease NN cord-007788-09t52zix 5 23 ( ( -LRB- cord-007788-09t52zix 5 24 GvHD GvHD NNP cord-007788-09t52zix 5 25 ) ) -RRB- cord-007788-09t52zix 5 26 ( ( -LRB- cord-007788-09t52zix 5 27 see see VB cord-007788-09t52zix 5 28 Chap Chap NNP cord-007788-09t52zix 5 29 . . . cord-007788-09t52zix 6 1 11 11 CD cord-007788-09t52zix 6 2 ) ) -RRB- cord-007788-09t52zix 6 3 , , , cord-007788-09t52zix 6 4 may may MD cord-007788-09t52zix 6 5 affect affect VB cord-007788-09t52zix 6 6 the the DT cord-007788-09t52zix 6 7 patient patient NN cord-007788-09t52zix 6 8 ’s ’s POS cord-007788-09t52zix 6 9 organs organ NNS cord-007788-09t52zix 6 10 and and CC cord-007788-09t52zix 6 11 tissues tissue NNS cord-007788-09t52zix 6 12 and and CC cord-007788-09t52zix 6 13 may may MD cord-007788-09t52zix 6 14 cause cause VB cord-007788-09t52zix 6 15 both both DT cord-007788-09t52zix 6 16 acute acute JJ cord-007788-09t52zix 6 17 and and CC cord-007788-09t52zix 6 18 long long JJ cord-007788-09t52zix 6 19 - - HYPH cord-007788-09t52zix 6 20 term term NN cord-007788-09t52zix 6 21 complications complication NNS cord-007788-09t52zix 6 22 . . . cord-007788-09t52zix 7 1 In in IN cord-007788-09t52zix 7 2 the the DT cord-007788-09t52zix 7 3 evolving evolve VBG cord-007788-09t52zix 7 4 field field NN cord-007788-09t52zix 7 5 of of IN cord-007788-09t52zix 7 6 stem stem NN cord-007788-09t52zix 7 7 cell cell NN cord-007788-09t52zix 7 8 therapies therapy NNS cord-007788-09t52zix 7 9 , , , cord-007788-09t52zix 7 10 some some DT cord-007788-09t52zix 7 11 complications complication NNS cord-007788-09t52zix 7 12 that that WDT cord-007788-09t52zix 7 13 traditionally traditionally RB cord-007788-09t52zix 7 14 have have VBP cord-007788-09t52zix 7 15 been be VBN cord-007788-09t52zix 7 16 regarded regard VBN cord-007788-09t52zix 7 17 as as IN cord-007788-09t52zix 7 18 early early JJ cord-007788-09t52zix 7 19 complications complication NNS cord-007788-09t52zix 7 20 are be VBP cord-007788-09t52zix 7 21 now now RB cord-007788-09t52zix 7 22 , , , cord-007788-09t52zix 7 23 due due IN cord-007788-09t52zix 7 24 to to IN cord-007788-09t52zix 7 25 changes change NNS cord-007788-09t52zix 7 26 in in IN cord-007788-09t52zix 7 27 preparative preparative JJ cord-007788-09t52zix 7 28 regimens regimen NNS cord-007788-09t52zix 7 29 and and CC cord-007788-09t52zix 7 30 choice choice NN cord-007788-09t52zix 7 31 of of IN cord-007788-09t52zix 7 32 stem stem NN cord-007788-09t52zix 7 33 cell cell NN cord-007788-09t52zix 7 34 source source NN cord-007788-09t52zix 7 35 , , , cord-007788-09t52zix 7 36 sometimes sometimes RB cord-007788-09t52zix 7 37 seen see VBN cord-007788-09t52zix 7 38 later later RB cord-007788-09t52zix 7 39 in in IN cord-007788-09t52zix 7 40 the the DT cord-007788-09t52zix 7 41 post post JJ cord-007788-09t52zix 7 42 - - JJ cord-007788-09t52zix 7 43 transplant transplant JJ cord-007788-09t52zix 7 44 out out IN cord-007788-09t52zix 7 45 - - HYPH cord-007788-09t52zix 7 46 patient patient NN cord-007788-09t52zix 7 47 setting setting NN cord-007788-09t52zix 7 48 . . . cord-007788-09t52zix 8 1 The the DT cord-007788-09t52zix 8 2 complications complication NNS cord-007788-09t52zix 8 3 covered cover VBN cord-007788-09t52zix 8 4 in in IN cord-007788-09t52zix 8 5 this this DT cord-007788-09t52zix 8 6 chapter chapter NN cord-007788-09t52zix 8 7 generally generally RB cord-007788-09t52zix 8 8 occur occur VBP cord-007788-09t52zix 8 9 within within IN cord-007788-09t52zix 8 10 100 100 CD cord-007788-09t52zix 8 11 days day NNS cord-007788-09t52zix 9 1 post post NNP cord-007788-09t52zix 9 2 HSCT HSCT NNP cord-007788-09t52zix 9 3 and and CC cord-007788-09t52zix 9 4 are be VBP cord-007788-09t52zix 9 5 thus thus RB cord-007788-09t52zix 9 6 classified classify VBN cord-007788-09t52zix 9 7 as as IN cord-007788-09t52zix 9 8 early early JJ cord-007788-09t52zix 9 9 complications complication NNS cord-007788-09t52zix 9 10 . . . cord-007788-09t52zix 10 1 Two two CD cord-007788-09t52zix 10 2 of of IN cord-007788-09t52zix 10 3 the the DT cord-007788-09t52zix 10 4 most most RBS cord-007788-09t52zix 10 5 common common JJ cord-007788-09t52zix 10 6 early early JJ cord-007788-09t52zix 10 7 complications complication NNS cord-007788-09t52zix 10 8 are be VBP cord-007788-09t52zix 10 9 oral oral JJ cord-007788-09t52zix 10 10 complications complication NNS cord-007788-09t52zix 10 11 / / SYM cord-007788-09t52zix 10 12 mucositis mucositis NN cord-007788-09t52zix 10 13 and and CC cord-007788-09t52zix 10 14 sepsis sepsis NN cord-007788-09t52zix 10 15 . . . cord-007788-09t52zix 11 1 Some some DT cord-007788-09t52zix 11 2 other other JJ cord-007788-09t52zix 11 3 relatively relatively RB cord-007788-09t52zix 11 4 rare rare JJ cord-007788-09t52zix 11 5 complications complication NNS cord-007788-09t52zix 11 6 are be VBP cord-007788-09t52zix 11 7 also also RB cord-007788-09t52zix 11 8 covered cover VBN cord-007788-09t52zix 11 9 here here RB cord-007788-09t52zix 11 10 : : : cord-007788-09t52zix 11 11 haemorrhagic haemorrhagic JJ cord-007788-09t52zix 11 12 cystitis cystitis NN cord-007788-09t52zix 11 13 ( ( -LRB- cord-007788-09t52zix 11 14 HC HC NNP cord-007788-09t52zix 11 15 ) ) -RRB- cord-007788-09t52zix 11 16 , , , cord-007788-09t52zix 11 17 endothelial endothelial JJ cord-007788-09t52zix 11 18 damage damage NN cord-007788-09t52zix 11 19 ( ( -LRB- cord-007788-09t52zix 11 20 ED ED NNP cord-007788-09t52zix 11 21 ) ) -RRB- cord-007788-09t52zix 11 22 syndromes syndrome NNS cord-007788-09t52zix 11 23 including include VBG cord-007788-09t52zix 11 24 engraftment engraftment NNP cord-007788-09t52zix 11 25 syndrome syndrome NN cord-007788-09t52zix 11 26 ( ( -LRB- cord-007788-09t52zix 11 27 ES ES NNP cord-007788-09t52zix 11 28 ) ) -RRB- cord-007788-09t52zix 11 29 , , , cord-007788-09t52zix 11 30 idiopathic idiopathic JJ cord-007788-09t52zix 11 31 pneumonia pneumonia NN cord-007788-09t52zix 11 32 syndrome syndrome NN cord-007788-09t52zix 11 33 ( ( -LRB- cord-007788-09t52zix 11 34 IPS IPS NNP cord-007788-09t52zix 11 35 ) ) -RRB- cord-007788-09t52zix 11 36 , , , cord-007788-09t52zix 11 37 diffuse diffuse VB cord-007788-09t52zix 11 38 alveolar alveolar NN cord-007788-09t52zix 11 39 haemorrhage haemorrhage NN cord-007788-09t52zix 11 40 ( ( -LRB- cord-007788-09t52zix 11 41 DAH DAH NNP cord-007788-09t52zix 11 42 ) ) -RRB- cord-007788-09t52zix 11 43 , , , cord-007788-09t52zix 11 44 transplant transplant NN cord-007788-09t52zix 11 45 - - HYPH cord-007788-09t52zix 11 46 associated associate VBN cord-007788-09t52zix 11 47 microangiopathy microangiopathy NN cord-007788-09t52zix 11 48 ( ( -LRB- cord-007788-09t52zix 11 49 TAM TAM NNP cord-007788-09t52zix 11 50 ) ) -RRB- cord-007788-09t52zix 11 51 and and CC cord-007788-09t52zix 11 52 sinusoidal sinusoidal JJ cord-007788-09t52zix 11 53 obstruction obstruction NN cord-007788-09t52zix 11 54 syndrome syndrome NN cord-007788-09t52zix 11 55 / / SYM cord-007788-09t52zix 11 56 veno veno NNP cord-007788-09t52zix 11 57 - - HYPH cord-007788-09t52zix 11 58 occlusive occlusive JJ cord-007788-09t52zix 11 59 disease disease NN cord-007788-09t52zix 11 60 ( ( -LRB- cord-007788-09t52zix 11 61 SOS SOS NNP cord-007788-09t52zix 11 62 / / SYM cord-007788-09t52zix 11 63 VOD VOD NNP cord-007788-09t52zix 11 64 ) ) -RRB- cord-007788-09t52zix 11 65 . . . cord-007788-09t52zix 12 1 For for IN cord-007788-09t52zix 12 2 all all DT cord-007788-09t52zix 12 3 complications complication NNS cord-007788-09t52zix 12 4 , , , cord-007788-09t52zix 12 5 recommendations recommendation NNS cord-007788-09t52zix 12 6 for for IN cord-007788-09t52zix 12 7 prevention prevention NN cord-007788-09t52zix 12 8 and and CC cord-007788-09t52zix 12 9 principles principle NNS cord-007788-09t52zix 12 10 for for IN cord-007788-09t52zix 12 11 nursing nursing NN cord-007788-09t52zix 12 12 care care NN cord-007788-09t52zix 12 13 are be VBP cord-007788-09t52zix 12 14 presented present VBN cord-007788-09t52zix 12 15 since since IN cord-007788-09t52zix 12 16 careful careful JJ cord-007788-09t52zix 12 17 nursing nursing NN cord-007788-09t52zix 12 18 monitoring monitoring NN cord-007788-09t52zix 12 19 , , , cord-007788-09t52zix 12 20 prompt prompt JJ cord-007788-09t52zix 12 21 intervention intervention NN cord-007788-09t52zix 12 22 and and CC cord-007788-09t52zix 12 23 care care NN cord-007788-09t52zix 12 24 may may MD cord-007788-09t52zix 12 25 have have VB cord-007788-09t52zix 12 26 an an DT cord-007788-09t52zix 12 27 influence influence NN cord-007788-09t52zix 12 28 on on IN cord-007788-09t52zix 12 29 patients patient NNS cord-007788-09t52zix 12 30 ’ ' '' cord-007788-09t52zix 12 31 morbidity morbidity NN cord-007788-09t52zix 12 32 and and CC cord-007788-09t52zix 12 33 mortality mortality NN cord-007788-09t52zix 12 34 . . . cord-007788-09t52zix 13 1 Oral oral JJ cord-007788-09t52zix 13 2 Care Care NNP cord-007788-09t52zix 13 3 in in IN cord-007788-09t52zix 13 4 Transplantation transplantation NN cord-007788-09t52zix 13 5 Mindful mindful JJ cord-007788-09t52zix 13 6 of of IN cord-007788-09t52zix 13 7 the the DT cord-007788-09t52zix 13 8 many many JJ cord-007788-09t52zix 13 9 developments development NNS cord-007788-09t52zix 13 10 in in IN cord-007788-09t52zix 13 11 the the DT cord-007788-09t52zix 13 12 field field NN cord-007788-09t52zix 13 13 of of IN cord-007788-09t52zix 13 14 HSCT HSCT NNP cord-007788-09t52zix 13 15 aimed aim VBN cord-007788-09t52zix 13 16 at at IN cord-007788-09t52zix 13 17 improving improve VBG cord-007788-09t52zix 13 18 survival survival NN cord-007788-09t52zix 13 19 and and CC cord-007788-09t52zix 13 20 quality quality NN cord-007788-09t52zix 13 21 of of IN cord-007788-09t52zix 13 22 life life NN cord-007788-09t52zix 13 23 , , , cord-007788-09t52zix 13 24 the the DT cord-007788-09t52zix 13 25 correct correct JJ cord-007788-09t52zix 13 26 and and CC cord-007788-09t52zix 13 27 consistent consistent JJ cord-007788-09t52zix 13 28 approach approach NN cord-007788-09t52zix 13 29 to to IN cord-007788-09t52zix 13 30 managing manage VBG cord-007788-09t52zix 13 31 oral oral JJ cord-007788-09t52zix 13 32 care care NN cord-007788-09t52zix 13 33 problems problem NNS cord-007788-09t52zix 13 34 still still RB cord-007788-09t52zix 13 35 remains remain VBZ cord-007788-09t52zix 13 36 a a DT cord-007788-09t52zix 13 37 challenge challenge NN cord-007788-09t52zix 13 38 in in IN cord-007788-09t52zix 13 39 many many JJ cord-007788-09t52zix 13 40 transplant transplant NN cord-007788-09t52zix 13 41 settings setting NNS cord-007788-09t52zix 13 42 across across IN cord-007788-09t52zix 13 43 Europe Europe NNP cord-007788-09t52zix 13 44 . . . cord-007788-09t52zix 14 1 There there EX cord-007788-09t52zix 14 2 is be VBZ cord-007788-09t52zix 14 3 much much JJ cord-007788-09t52zix 14 4 evidence evidence NN cord-007788-09t52zix 14 5 to to TO cord-007788-09t52zix 14 6 show show VB cord-007788-09t52zix 14 7 that that IN cord-007788-09t52zix 14 8 rather rather RB cord-007788-09t52zix 14 9 than than IN cord-007788-09t52zix 14 10 taking take VBG cord-007788-09t52zix 14 11 a a DT cord-007788-09t52zix 14 12 proactive proactive JJ cord-007788-09t52zix 14 13 approach approach NN cord-007788-09t52zix 14 14 to to IN cord-007788-09t52zix 14 15 this this DT cord-007788-09t52zix 14 16 aspect aspect NN cord-007788-09t52zix 14 17 of of IN cord-007788-09t52zix 14 18 care care NN cord-007788-09t52zix 14 19 , , , cord-007788-09t52zix 14 20 many many JJ cord-007788-09t52zix 14 21 clinicians clinician NNS cord-007788-09t52zix 14 22 simply simply RB cord-007788-09t52zix 14 23 react react VBP cord-007788-09t52zix 14 24 to to IN cord-007788-09t52zix 14 25 oral oral JJ cord-007788-09t52zix 14 26 complications complication NNS cord-007788-09t52zix 14 27 once once IN cord-007788-09t52zix 14 28 they -PRON- PRP cord-007788-09t52zix 14 29 occur occur VBP cord-007788-09t52zix 14 30 with with IN cord-007788-09t52zix 14 31 a a DT cord-007788-09t52zix 14 32 sometimes sometimes RB cord-007788-09t52zix 14 33 inconsistent inconsistent JJ cord-007788-09t52zix 14 34 and and CC cord-007788-09t52zix 14 35 anecdotal anecdotal JJ cord-007788-09t52zix 14 36 approach approach NN cord-007788-09t52zix 14 37 . . . cord-007788-09t52zix 15 1 Oral oral JJ cord-007788-09t52zix 15 2 problems problem NNS cord-007788-09t52zix 15 3 and and CC cord-007788-09t52zix 15 4 damage damage NN cord-007788-09t52zix 15 5 may may MD cord-007788-09t52zix 15 6 be be VB cord-007788-09t52zix 15 7 temporary temporary JJ cord-007788-09t52zix 15 8 or or CC cord-007788-09t52zix 15 9 permanent permanent JJ cord-007788-09t52zix 15 10 resulting resulting NN cord-007788-09t52zix 15 11 in in IN cord-007788-09t52zix 15 12 a a DT cord-007788-09t52zix 15 13 significant significant JJ cord-007788-09t52zix 15 14 health health NN cord-007788-09t52zix 15 15 burden burden NN cord-007788-09t52zix 15 16 for for IN cord-007788-09t52zix 15 17 the the DT cord-007788-09t52zix 15 18 individual individual NN cord-007788-09t52zix 15 19 while while IN cord-007788-09t52zix 15 20 making make VBG cord-007788-09t52zix 15 21 substantial substantial JJ cord-007788-09t52zix 15 22 demands demand NNS cord-007788-09t52zix 15 23 on on IN cord-007788-09t52zix 15 24 limited limited JJ cord-007788-09t52zix 15 25 healthcare healthcare NN cord-007788-09t52zix 15 26 resources resource NNS cord-007788-09t52zix 15 27 . . . cord-007788-09t52zix 16 1 However however RB cord-007788-09t52zix 16 2 , , , cord-007788-09t52zix 16 3 oral oral JJ cord-007788-09t52zix 16 4 complications complication NNS cord-007788-09t52zix 16 5 are be VBP cord-007788-09t52zix 16 6 not not RB cord-007788-09t52zix 16 7 always always RB cord-007788-09t52zix 16 8 inevitable inevitable JJ cord-007788-09t52zix 16 9 , , , cord-007788-09t52zix 16 10 and and CC cord-007788-09t52zix 16 11 much much JJ cord-007788-09t52zix 16 12 can can MD cord-007788-09t52zix 16 13 be be VB cord-007788-09t52zix 16 14 done do VBN cord-007788-09t52zix 16 15 to to TO cord-007788-09t52zix 16 16 reduce reduce VB cord-007788-09t52zix 16 17 or or CC cord-007788-09t52zix 16 18 minimise minimise VB cord-007788-09t52zix 16 19 the the DT cord-007788-09t52zix 16 20 severity severity NN cord-007788-09t52zix 16 21 of of IN cord-007788-09t52zix 16 22 symptoms symptom NNS cord-007788-09t52zix 16 23 by by IN cord-007788-09t52zix 16 24 taking take VBG cord-007788-09t52zix 16 25 a a DT cord-007788-09t52zix 16 26 more more RBR cord-007788-09t52zix 16 27 proactive proactive JJ cord-007788-09t52zix 16 28 approach approach NN cord-007788-09t52zix 16 29 to to IN cord-007788-09t52zix 16 30 this this DT cord-007788-09t52zix 16 31 aspect aspect NN cord-007788-09t52zix 16 32 of of IN cord-007788-09t52zix 16 33 care care NN cord-007788-09t52zix 16 34 . . . cord-007788-09t52zix 17 1 Working work VBG cord-007788-09t52zix 17 2 as as IN cord-007788-09t52zix 17 3 a a DT cord-007788-09t52zix 17 4 multidisciplinary multidisciplinary JJ cord-007788-09t52zix 17 5 team team NN cord-007788-09t52zix 17 6 with with IN cord-007788-09t52zix 17 7 the the DT cord-007788-09t52zix 17 8 patient patient NN cord-007788-09t52zix 17 9 at at IN cord-007788-09t52zix 17 10 the the DT cord-007788-09t52zix 17 11 centre centre NN cord-007788-09t52zix 17 12 of of IN cord-007788-09t52zix 17 13 care care NN cord-007788-09t52zix 17 14 and and CC cord-007788-09t52zix 17 15 treatment treatment NN cord-007788-09t52zix 17 16 plan plan NN cord-007788-09t52zix 17 17 , , , cord-007788-09t52zix 17 18 the the DT cord-007788-09t52zix 17 19 early early JJ cord-007788-09t52zix 17 20 detection detection NN cord-007788-09t52zix 17 21 of of IN cord-007788-09t52zix 17 22 potential potential JJ cord-007788-09t52zix 17 23 and and CC cord-007788-09t52zix 17 24 actual actual JJ cord-007788-09t52zix 17 25 problems problem NNS cord-007788-09t52zix 17 26 and and CC cord-007788-09t52zix 17 27 treatment treatment NN cord-007788-09t52zix 17 28 can can MD cord-007788-09t52zix 17 29 help help VB cord-007788-09t52zix 17 30 to to TO cord-007788-09t52zix 17 31 reduce reduce VB cord-007788-09t52zix 17 32 oral oral JJ cord-007788-09t52zix 17 33 problems problem NNS cord-007788-09t52zix 17 34 and and CC cord-007788-09t52zix 17 35 prevent prevent VB cord-007788-09t52zix 17 36 interruptions interruption NNS cord-007788-09t52zix 17 37 to to IN cord-007788-09t52zix 17 38 treatment treatment NN cord-007788-09t52zix 17 39 while while IN cord-007788-09t52zix 17 40 maximising maximise VBG cord-007788-09t52zix 17 41 patient patient JJ cord-007788-09t52zix 17 42 safety safety NN cord-007788-09t52zix 17 43 and and CC cord-007788-09t52zix 17 44 comfort comfort NN cord-007788-09t52zix 17 45 ( ( -LRB- cord-007788-09t52zix 17 46 National National NNP cord-007788-09t52zix 17 47 Cancer Cancer NNP cord-007788-09t52zix 17 48 Institute Institute NNP cord-007788-09t52zix 17 49 2013 2013 CD cord-007788-09t52zix 17 50 ) ) -RRB- cord-007788-09t52zix 17 51 . . . cord-007788-09t52zix 18 1 Oral oral JJ cord-007788-09t52zix 18 2 mucositis mucositis NN cord-007788-09t52zix 18 3 ( ( -LRB- cord-007788-09t52zix 18 4 OM OM NNP cord-007788-09t52zix 18 5 ) ) -RRB- cord-007788-09t52zix 18 6 has have VBZ cord-007788-09t52zix 18 7 been be VBN cord-007788-09t52zix 18 8 defined define VBN cord-007788-09t52zix 18 9 by by IN cord-007788-09t52zix 18 10 Rubenstein Rubenstein NNP cord-007788-09t52zix 18 11 et et NNP cord-007788-09t52zix 18 12 al al NNP cord-007788-09t52zix 18 13 . . . cord-007788-09t52zix 19 1 ( ( -LRB- cord-007788-09t52zix 19 2 2004 2004 CD cord-007788-09t52zix 19 3 ) ) -RRB- cord-007788-09t52zix 19 4 , , , cord-007788-09t52zix 19 5 Al Al NNP cord-007788-09t52zix 19 6 - - HYPH cord-007788-09t52zix 19 7 Dasoogi Dasoogi NNP cord-007788-09t52zix 19 8 et et FW cord-007788-09t52zix 19 9 al al NNP cord-007788-09t52zix 19 10 . . . cord-007788-09t52zix 20 1 ( ( -LRB- cord-007788-09t52zix 20 2 2013 2013 CD cord-007788-09t52zix 20 3 ) ) -RRB- cord-007788-09t52zix 20 4 and and CC cord-007788-09t52zix 20 5 others other NNS cord-007788-09t52zix 20 6 as as IN cord-007788-09t52zix 20 7 the the DT cord-007788-09t52zix 20 8 inflammation inflammation NN cord-007788-09t52zix 20 9 of of IN cord-007788-09t52zix 20 10 the the DT cord-007788-09t52zix 20 11 mucosal mucosal JJ cord-007788-09t52zix 20 12 membrane membrane NN cord-007788-09t52zix 20 13 , , , cord-007788-09t52zix 20 14 characterised characterise VBN cord-007788-09t52zix 20 15 by by IN cord-007788-09t52zix 20 16 ulceration ulceration NN cord-007788-09t52zix 20 17 , , , cord-007788-09t52zix 20 18 which which WDT cord-007788-09t52zix 20 19 may may MD cord-007788-09t52zix 20 20 result result VB cord-007788-09t52zix 20 21 in in IN cord-007788-09t52zix 20 22 pain pain NN cord-007788-09t52zix 20 23 , , , cord-007788-09t52zix 20 24 swallowing swallow VBG cord-007788-09t52zix 20 25 difficulties difficulty NNS cord-007788-09t52zix 20 26 and and CC cord-007788-09t52zix 20 27 impairment impairment NN cord-007788-09t52zix 20 28 of of IN cord-007788-09t52zix 20 29 the the DT cord-007788-09t52zix 20 30 ability ability NN cord-007788-09t52zix 20 31 to to TO cord-007788-09t52zix 20 32 talk talk VB cord-007788-09t52zix 20 33 . . . cord-007788-09t52zix 21 1 The the DT cord-007788-09t52zix 21 2 mucosal mucosal JJ cord-007788-09t52zix 21 3 injury injury NN cord-007788-09t52zix 21 4 caused cause VBN cord-007788-09t52zix 21 5 by by IN cord-007788-09t52zix 21 6 OM OM NNP cord-007788-09t52zix 21 7 provides provide VBZ cord-007788-09t52zix 21 8 an an DT cord-007788-09t52zix 21 9 opportunity opportunity NN cord-007788-09t52zix 21 10 for for IN cord-007788-09t52zix 21 11 infection infection NN cord-007788-09t52zix 21 12 to to TO cord-007788-09t52zix 21 13 flourish flourish VB cord-007788-09t52zix 21 14 , , , cord-007788-09t52zix 21 15 and and CC cord-007788-09t52zix 21 16 in in IN cord-007788-09t52zix 21 17 particular particular JJ cord-007788-09t52zix 21 18 putting put VBG cord-007788-09t52zix 21 19 the the DT cord-007788-09t52zix 21 20 severely severely RB cord-007788-09t52zix 21 21 immunocompromised immunocompromised JJ cord-007788-09t52zix 21 22 patient patient NN cord-007788-09t52zix 21 23 in in IN cord-007788-09t52zix 21 24 the the DT cord-007788-09t52zix 21 25 HSCT HSCT NNP cord-007788-09t52zix 21 26 setting set VBG cord-007788-09t52zix 21 27 at at IN cord-007788-09t52zix 21 28 risk risk NN cord-007788-09t52zix 21 29 of of IN cord-007788-09t52zix 21 30 sepsis sepsis NN cord-007788-09t52zix 21 31 and and CC cord-007788-09t52zix 21 32 septicaemia septicaemia NN cord-007788-09t52zix 21 33 . . . cord-007788-09t52zix 22 1 OM om NN cord-007788-09t52zix 22 2 and and CC cord-007788-09t52zix 22 3 oral oral JJ cord-007788-09t52zix 22 4 problems problem NNS cord-007788-09t52zix 22 5 in in IN cord-007788-09t52zix 22 6 the the DT cord-007788-09t52zix 22 7 HSCT HSCT NNP cord-007788-09t52zix 22 8 setting setting NN cord-007788-09t52zix 22 9 ( ( -LRB- cord-007788-09t52zix 22 10 Table table NN cord-007788-09t52zix 22 11 9 9 CD cord-007788-09t52zix 22 12 .1 .1 NFP cord-007788-09t52zix 22 13 ) ) -RRB- cord-007788-09t52zix 22 14 can can MD cord-007788-09t52zix 22 15 be be VB cord-007788-09t52zix 22 16 expected expect VBN cord-007788-09t52zix 22 17 to to TO cord-007788-09t52zix 22 18 occur occur VB cord-007788-09t52zix 22 19 in in IN cord-007788-09t52zix 22 20 as as RB cord-007788-09t52zix 22 21 many many JJ cord-007788-09t52zix 22 22 as as IN cord-007788-09t52zix 22 23 68 68 CD cord-007788-09t52zix 22 24 % % NN cord-007788-09t52zix 22 25 of of IN cord-007788-09t52zix 22 26 patients patient NNS cord-007788-09t52zix 22 27 undergoing undergo VBG cord-007788-09t52zix 22 28 autologous autologous JJ cord-007788-09t52zix 22 29 HSCT HSCT NNP cord-007788-09t52zix 22 30 and and CC cord-007788-09t52zix 22 31 98 98 CD cord-007788-09t52zix 22 32 % % NN cord-007788-09t52zix 22 33 of of IN cord-007788-09t52zix 22 34 patients patient NNS cord-007788-09t52zix 22 35 undergoing undergo VBG cord-007788-09t52zix 22 36 allogeneic allogeneic IN cord-007788-09t52zix 22 37 HSCT HSCT NNP cord-007788-09t52zix 22 38 ( ( -LRB- cord-007788-09t52zix 22 39 Filicko Filicko NNP cord-007788-09t52zix 22 40 et et NNP cord-007788-09t52zix 22 41 al al NNP cord-007788-09t52zix 22 42 . . NNP cord-007788-09t52zix 22 43 2003 2003 CD cord-007788-09t52zix 22 44 ; ; : cord-007788-09t52zix 22 45 Bhatt Bhatt NNP cord-007788-09t52zix 22 46 et et NNP cord-007788-09t52zix 22 47 al al NNP cord-007788-09t52zix 22 48 . . NNP cord-007788-09t52zix 22 49 2010 2010 CD cord-007788-09t52zix 22 50 ) ) -RRB- cord-007788-09t52zix 22 51 . . . cord-007788-09t52zix 23 1 With with IN cord-007788-09t52zix 23 2 the the DT cord-007788-09t52zix 23 3 increasing increase VBG cord-007788-09t52zix 23 4 use use NN cord-007788-09t52zix 23 5 of of IN cord-007788-09t52zix 23 6 targeted target VBN cord-007788-09t52zix 23 7 drug drug NN cord-007788-09t52zix 23 8 therapies therapy NNS cord-007788-09t52zix 23 9 and and CC cord-007788-09t52zix 23 10 approaches approach NNS cord-007788-09t52zix 23 11 in in IN cord-007788-09t52zix 23 12 the the DT cord-007788-09t52zix 23 13 cancer cancer NN cord-007788-09t52zix 23 14 and and CC cord-007788-09t52zix 23 15 haematology haematology NN cord-007788-09t52zix 23 16 setting setting NN cord-007788-09t52zix 23 17 , , , cord-007788-09t52zix 23 18 problems problem NNS cord-007788-09t52zix 23 19 in in IN cord-007788-09t52zix 23 20 the the DT cord-007788-09t52zix 23 21 oral oral JJ cord-007788-09t52zix 23 22 cavity cavity NN cord-007788-09t52zix 23 23 will will MD cord-007788-09t52zix 23 24 increase increase VB cord-007788-09t52zix 23 25 and and CC cord-007788-09t52zix 23 26 become become VB cord-007788-09t52zix 23 27 even even RB cord-007788-09t52zix 23 28 more more JJR cord-007788-09t52zix 23 29 of of IN cord-007788-09t52zix 23 30 a a DT cord-007788-09t52zix 23 31 challenge challenge NN cord-007788-09t52zix 23 32 . . . cord-007788-09t52zix 24 1 All all DT cord-007788-09t52zix 24 2 treatment treatment NN cord-007788-09t52zix 24 3 strategies strategy NNS cord-007788-09t52zix 24 4 aimed aim VBN cord-007788-09t52zix 24 5 at at IN cord-007788-09t52zix 24 6 improving improve VBG cord-007788-09t52zix 24 7 mouth mouth NN cord-007788-09t52zix 24 8 care care NN cord-007788-09t52zix 24 9 are be VBP cord-007788-09t52zix 24 10 dependent dependent JJ cord-007788-09t52zix 24 11 on on IN cord-007788-09t52zix 24 12 four four CD cord-007788-09t52zix 24 13 key key JJ cord-007788-09t52zix 24 14 principles principle NNS cord-007788-09t52zix 24 15 : : : cord-007788-09t52zix 24 16 accurate accurate JJ cord-007788-09t52zix 24 17 assessment assessment NN cord-007788-09t52zix 24 18 of of IN cord-007788-09t52zix 24 19 the the DT cord-007788-09t52zix 24 20 oral oral JJ cord-007788-09t52zix 24 21 cavity cavity NN cord-007788-09t52zix 24 22 , , , cord-007788-09t52zix 24 23 individualised individualised JJ cord-007788-09t52zix 24 24 plan plan NN cord-007788-09t52zix 24 25 of of IN cord-007788-09t52zix 24 26 care care NN cord-007788-09t52zix 24 27 , , , cord-007788-09t52zix 24 28 initiating initiate VBG cord-007788-09t52zix 24 29 timely timely JJ cord-007788-09t52zix 24 30 preventative preventative JJ cord-007788-09t52zix 24 31 measures measure NNS cord-007788-09t52zix 24 32 and and CC cord-007788-09t52zix 24 33 correct correct JJ cord-007788-09t52zix 24 34 treatment treatment NN cord-007788-09t52zix 24 35 ( ( -LRB- cord-007788-09t52zix 24 36 Quinn Quinn NNP cord-007788-09t52zix 24 37 et et NNP cord-007788-09t52zix 24 38 al al NNP cord-007788-09t52zix 24 39 . . NNP cord-007788-09t52zix 24 40 2008 2008 CD cord-007788-09t52zix 24 41 ) ) -RRB- cord-007788-09t52zix 24 42 . . . cord-007788-09t52zix 25 1 The the DT cord-007788-09t52zix 25 2 assessment assessment NN cord-007788-09t52zix 25 3 process process NN cord-007788-09t52zix 25 4 should should MD cord-007788-09t52zix 25 5 begin begin VB cord-007788-09t52zix 25 6 prior prior RB cord-007788-09t52zix 25 7 to to IN cord-007788-09t52zix 25 8 HSCT HSCT NNP cord-007788-09t52zix 25 9 by by IN cord-007788-09t52zix 25 10 identifying identify VBG cord-007788-09t52zix 25 11 all all PDT cord-007788-09t52zix 25 12 the the DT cord-007788-09t52zix 25 13 patient patient NN cord-007788-09t52zix 25 14 risks risk VBZ cord-007788-09t52zix 25 15 most most RBS cord-007788-09t52zix 25 16 likely likely JJ cord-007788-09t52zix 25 17 to to TO cord-007788-09t52zix 25 18 increase increase VB cord-007788-09t52zix 25 19 oral oral JJ cord-007788-09t52zix 25 20 damage damage NN cord-007788-09t52zix 25 21 . . . cord-007788-09t52zix 26 1 Each each DT cord-007788-09t52zix 26 2 patient patient NN cord-007788-09t52zix 26 3 needs need VBZ cord-007788-09t52zix 26 4 to to TO cord-007788-09t52zix 26 5 be be VB cord-007788-09t52zix 26 6 assessed assess VBN cord-007788-09t52zix 26 7 in in IN cord-007788-09t52zix 26 8 relation relation NN cord-007788-09t52zix 26 9 to to IN cord-007788-09t52zix 26 10 the the DT cord-007788-09t52zix 26 11 following follow VBG cord-007788-09t52zix 26 12 risk risk NN cord-007788-09t52zix 26 13 factors factor NNS cord-007788-09t52zix 26 14 that that WDT cord-007788-09t52zix 26 15 may may MD cord-007788-09t52zix 26 16 put put VB cord-007788-09t52zix 26 17 them -PRON- PRP cord-007788-09t52zix 26 18 at at IN cord-007788-09t52zix 26 19 higher high JJR cord-007788-09t52zix 26 20 risk risk NN cord-007788-09t52zix 26 21 of of IN cord-007788-09t52zix 26 22 oral oral JJ cord-007788-09t52zix 26 23 complications complication NNS cord-007788-09t52zix 26 24 during during IN cord-007788-09t52zix 26 25 treatment treatment NN cord-007788-09t52zix 26 26 : : : cord-007788-09t52zix 26 27 Patients patient NNS cord-007788-09t52zix 26 28 about about IN cord-007788-09t52zix 26 29 to to TO cord-007788-09t52zix 26 30 commence commence VB cord-007788-09t52zix 26 31 HSCT HSCT NNP cord-007788-09t52zix 26 32 should should MD cord-007788-09t52zix 26 33 undergo undergo VB cord-007788-09t52zix 26 34 dental dental JJ cord-007788-09t52zix 26 35 assessment assessment NN cord-007788-09t52zix 26 36 by by IN cord-007788-09t52zix 26 37 a a DT cord-007788-09t52zix 26 38 specialist specialist NN cord-007788-09t52zix 26 39 ( ( -LRB- cord-007788-09t52zix 26 40 Elad Elad NNP cord-007788-09t52zix 26 41 et et NNP cord-007788-09t52zix 26 42 al al NNP cord-007788-09t52zix 26 43 . . NNP cord-007788-09t52zix 26 44 2015 2015 CD cord-007788-09t52zix 26 45 ) ) -RRB- cord-007788-09t52zix 26 46 . . . cord-007788-09t52zix 27 1 This this DT cord-007788-09t52zix 27 2 is be VBZ cord-007788-09t52zix 27 3 to to TO cord-007788-09t52zix 27 4 establish establish VB cord-007788-09t52zix 27 5 general general JJ cord-007788-09t52zix 27 6 oral oral JJ cord-007788-09t52zix 27 7 health health NN cord-007788-09t52zix 27 8 status status NN cord-007788-09t52zix 27 9 and and CC cord-007788-09t52zix 27 10 identify identify VB cord-007788-09t52zix 27 11 and and CC cord-007788-09t52zix 27 12 manage manage VB cord-007788-09t52zix 27 13 existing exist VBG cord-007788-09t52zix 27 14 and/or and/or CC cord-007788-09t52zix 27 15 potential potential JJ cord-007788-09t52zix 27 16 source source NN cord-007788-09t52zix 27 17 of of IN cord-007788-09t52zix 27 18 infection infection NN cord-007788-09t52zix 27 19 , , , cord-007788-09t52zix 27 20 trauma trauma NN cord-007788-09t52zix 27 21 or or CC cord-007788-09t52zix 27 22 injury injury NN cord-007788-09t52zix 27 23 . . . cord-007788-09t52zix 28 1 Any any DT cord-007788-09t52zix 28 2 identified identify VBN cord-007788-09t52zix 28 3 dental dental JJ cord-007788-09t52zix 28 4 problems problem NNS cord-007788-09t52zix 28 5 should should MD cord-007788-09t52zix 28 6 be be VB cord-007788-09t52zix 28 7 corrected correct VBN cord-007788-09t52zix 28 8 before before IN cord-007788-09t52zix 28 9 starting start VBG cord-007788-09t52zix 28 10 treatment treatment NN cord-007788-09t52zix 28 11 regimen regimen NN cord-007788-09t52zix 28 12 . . . cord-007788-09t52zix 29 1 Some some DT cord-007788-09t52zix 29 2 patients patient NNS cord-007788-09t52zix 29 3 will will MD cord-007788-09t52zix 29 4 need need VB cord-007788-09t52zix 29 5 regular regular JJ cord-007788-09t52zix 29 6 dental dental JJ cord-007788-09t52zix 29 7 follow follow NN cord-007788-09t52zix 29 8 - - HYPH cord-007788-09t52zix 29 9 up up NN cord-007788-09t52zix 29 10 following follow VBG cord-007788-09t52zix 29 11 treatment treatment NN cord-007788-09t52zix 29 12 . . . cord-007788-09t52zix 30 1 A a DT cord-007788-09t52zix 30 2 further further JJ cord-007788-09t52zix 30 3 baseline baseline JJ cord-007788-09t52zix 30 4 assessment assessment NN cord-007788-09t52zix 30 5 of of IN cord-007788-09t52zix 30 6 the the DT cord-007788-09t52zix 30 7 oral oral JJ cord-007788-09t52zix 30 8 mucosa mucosa NN cord-007788-09t52zix 30 9 should should MD cord-007788-09t52zix 30 10 be be VB cord-007788-09t52zix 30 11 taken take VBN cord-007788-09t52zix 30 12 as as RB cord-007788-09t52zix 30 13 close close JJ cord-007788-09t52zix 30 14 to to IN cord-007788-09t52zix 30 15 the the DT cord-007788-09t52zix 30 16 administration administration NN cord-007788-09t52zix 30 17 of of IN cord-007788-09t52zix 30 18 the the DT cord-007788-09t52zix 30 19 first first JJ cord-007788-09t52zix 30 20 treatment treatment NN cord-007788-09t52zix 30 21 dose dose NN cord-007788-09t52zix 30 22 as as IN cord-007788-09t52zix 30 23 possible possible JJ cord-007788-09t52zix 30 24 . . . cord-007788-09t52zix 31 1 The the DT cord-007788-09t52zix 31 2 oral oral JJ cord-007788-09t52zix 31 3 cavity cavity NN cord-007788-09t52zix 31 4 should should MD cord-007788-09t52zix 31 5 be be VB cord-007788-09t52zix 31 6 assessed assess VBN cord-007788-09t52zix 31 7 by by IN cord-007788-09t52zix 31 8 trained train VBN cord-007788-09t52zix 31 9 healthcare healthcare NN cord-007788-09t52zix 31 10 professionals professional NNS cord-007788-09t52zix 31 11 using use VBG cord-007788-09t52zix 31 12 a a DT cord-007788-09t52zix 31 13 recognised recognise VBN cord-007788-09t52zix 31 14 grading grading NN cord-007788-09t52zix 31 15 system system NN cord-007788-09t52zix 31 16 to to TO cord-007788-09t52zix 31 17 ensure ensure VB cord-007788-09t52zix 31 18 accurate accurate JJ cord-007788-09t52zix 31 19 monitoring monitoring NN cord-007788-09t52zix 31 20 and and CC cord-007788-09t52zix 31 21 record record NN cord-007788-09t52zix 31 22 keeping keeping NN cord-007788-09t52zix 31 23 . . . cord-007788-09t52zix 32 1 The the DT cord-007788-09t52zix 32 2 tool tool NN cord-007788-09t52zix 32 3 chosen choose VBN cord-007788-09t52zix 32 4 should should MD cord-007788-09t52zix 32 5 contain contain VB cord-007788-09t52zix 32 6 both both DT cord-007788-09t52zix 32 7 objective objective JJ cord-007788-09t52zix 32 8 and and CC cord-007788-09t52zix 32 9 subjective subjective JJ cord-007788-09t52zix 32 10 elements element NNS cord-007788-09t52zix 32 11 . . . cord-007788-09t52zix 33 1 The the DT cord-007788-09t52zix 33 2 assessment assessment NN cord-007788-09t52zix 33 3 should should MD cord-007788-09t52zix 33 4 include include VB cord-007788-09t52zix 33 5 changes change NNS cord-007788-09t52zix 33 6 to to IN cord-007788-09t52zix 33 7 the the DT cord-007788-09t52zix 33 8 oral oral JJ cord-007788-09t52zix 33 9 mucosa mucosa NN cord-007788-09t52zix 33 10 , , , cord-007788-09t52zix 33 11 the the DT cord-007788-09t52zix 33 12 presence presence NN cord-007788-09t52zix 33 13 or or CC cord-007788-09t52zix 33 14 absence absence NN cord-007788-09t52zix 33 15 of of IN cord-007788-09t52zix 33 16 pain pain NN cord-007788-09t52zix 33 17 and and CC cord-007788-09t52zix 33 18 the the DT cord-007788-09t52zix 33 19 patient patient NN cord-007788-09t52zix 33 20 's 's POS cord-007788-09t52zix 33 21 nutritional nutritional JJ cord-007788-09t52zix 33 22 status status NN cord-007788-09t52zix 34 1 ( ( -LRB- cord-007788-09t52zix 34 2 Quinn Quinn NNP cord-007788-09t52zix 34 3 et et NNP cord-007788-09t52zix 34 4 al al NNP cord-007788-09t52zix 34 5 . . NNP cord-007788-09t52zix 34 6 2008 2008 CD cord-007788-09t52zix 34 7 ) ) -RRB- cord-007788-09t52zix 34 8 . . . cord-007788-09t52zix 35 1 Assessments assessment NNS cord-007788-09t52zix 35 2 should should MD cord-007788-09t52zix 35 3 be be VB cord-007788-09t52zix 35 4 completed complete VBN cord-007788-09t52zix 35 5 daily daily RB cord-007788-09t52zix 35 6 during during IN cord-007788-09t52zix 35 7 HSCT HSCT NNP cord-007788-09t52zix 35 8 and and CC cord-007788-09t52zix 35 9 at at IN cord-007788-09t52zix 35 10 regular regular JJ cord-007788-09t52zix 35 11 intervals interval NNS cord-007788-09t52zix 35 12 posttreatment posttreatment NN cord-007788-09t52zix 35 13 to to TO cord-007788-09t52zix 35 14 monitor monitor VB cord-007788-09t52zix 35 15 for for IN cord-007788-09t52zix 35 16 complications complication NNS cord-007788-09t52zix 35 17 . . . cord-007788-09t52zix 36 1 Patients patient NNS cord-007788-09t52zix 36 2 can can MD cord-007788-09t52zix 36 3 be be VB cord-007788-09t52zix 36 4 encouraged encourage VBN cord-007788-09t52zix 36 5 to to TO cord-007788-09t52zix 36 6 assess assess VB cord-007788-09t52zix 36 7 their -PRON- PRP$ cord-007788-09t52zix 36 8 own own JJ cord-007788-09t52zix 36 9 mouth mouth NN cord-007788-09t52zix 36 10 using use VBG cord-007788-09t52zix 36 11 a a DT cord-007788-09t52zix 36 12 patient patient NN cord-007788-09t52zix 36 13 - - HYPH cord-007788-09t52zix 36 14 reported report VBN cord-007788-09t52zix 36 15 tool tool NN cord-007788-09t52zix 36 16 and and CC cord-007788-09t52zix 36 17 to to TO cord-007788-09t52zix 36 18 report report VB cord-007788-09t52zix 36 19 any any DT cord-007788-09t52zix 36 20 changes change NNS cord-007788-09t52zix 36 21 they -PRON- PRP cord-007788-09t52zix 36 22 notice notice VBP cord-007788-09t52zix 36 23 or or CC cord-007788-09t52zix 36 24 experience experience NN cord-007788-09t52zix 36 25 to to IN cord-007788-09t52zix 36 26 the the DT cord-007788-09t52zix 36 27 transplant transplant NN cord-007788-09t52zix 36 28 team team NN cord-007788-09t52zix 36 29 . . . cord-007788-09t52zix 37 1 • • NNP cord-007788-09t52zix 38 1 Clinical clinical JJ cord-007788-09t52zix 38 2 tools tool NNS cord-007788-09t52zix 38 3 : : : cord-007788-09t52zix 38 4 good good JJ cord-007788-09t52zix 38 5 light light JJ cord-007788-09t52zix 38 6 source source NN cord-007788-09t52zix 38 7 , , , cord-007788-09t52zix 38 8 gloves glove NNS cord-007788-09t52zix 38 9 , , , cord-007788-09t52zix 38 10 tongue tongue NN cord-007788-09t52zix 38 11 depressor depressor NN cord-007788-09t52zix 38 12 and and CC cord-007788-09t52zix 38 13 dry dry JJ cord-007788-09t52zix 38 14 gauze gauze NN cord-007788-09t52zix 39 1 • • NNP cord-007788-09t52zix 40 1 Patient patient JJ cord-007788-09t52zix 40 2 in in IN cord-007788-09t52zix 40 3 convenient convenient JJ cord-007788-09t52zix 40 4 and and CC cord-007788-09t52zix 40 5 comfortable comfortable JJ cord-007788-09t52zix 40 6 position position NN cord-007788-09t52zix 41 1 • • NNP cord-007788-09t52zix 42 1 Use use VB cord-007788-09t52zix 42 2 valid valid JJ cord-007788-09t52zix 42 3 and and CC cord-007788-09t52zix 42 4 reliable reliable JJ cord-007788-09t52zix 42 5 assessment assessment NN cord-007788-09t52zix 42 6 instrument instrument NN cord-007788-09t52zix 42 7 which which WDT cord-007788-09t52zix 42 8 is be VBZ cord-007788-09t52zix 42 9 easy easy JJ cord-007788-09t52zix 42 10 to to TO cord-007788-09t52zix 42 11 interpret interpret VB cord-007788-09t52zix 42 12 • • NNP cord-007788-09t52zix 42 13 Oral oral JJ cord-007788-09t52zix 42 14 sites site NNS cord-007788-09t52zix 42 15 to to TO cord-007788-09t52zix 42 16 be be VB cord-007788-09t52zix 42 17 evaluated evaluate VBN cord-007788-09t52zix 42 18 ( ( -LRB- cord-007788-09t52zix 42 19 cheeks cheek NNS cord-007788-09t52zix 42 20 , , , cord-007788-09t52zix 42 21 lips lip NNS cord-007788-09t52zix 42 22 , , , cord-007788-09t52zix 42 23 soft soft JJ cord-007788-09t52zix 42 24 palate palate NN cord-007788-09t52zix 42 25 , , , cord-007788-09t52zix 42 26 floor floor NN cord-007788-09t52zix 42 27 of of IN cord-007788-09t52zix 42 28 mouth mouth NN cord-007788-09t52zix 42 29 , , , cord-007788-09t52zix 42 30 tongue tongue NN cord-007788-09t52zix 42 31 ) ) -RRB- cord-007788-09t52zix 43 1 Care care NN cord-007788-09t52zix 43 2 of of IN cord-007788-09t52zix 43 3 the the DT cord-007788-09t52zix 43 4 oral oral JJ cord-007788-09t52zix 43 5 cavity cavity NN cord-007788-09t52zix 43 6 is be VBZ cord-007788-09t52zix 43 7 central central JJ cord-007788-09t52zix 43 8 to to IN cord-007788-09t52zix 43 9 helping help VBG cord-007788-09t52zix 43 10 to to TO cord-007788-09t52zix 43 11 prevent prevent VB cord-007788-09t52zix 43 12 and/or and/or CC cord-007788-09t52zix 43 13 reduce reduce VB cord-007788-09t52zix 43 14 oral oral JJ cord-007788-09t52zix 43 15 complications complication NNS cord-007788-09t52zix 43 16 during during IN cord-007788-09t52zix 43 17 and and CC cord-007788-09t52zix 43 18 after after IN cord-007788-09t52zix 43 19 treatment treatment NN cord-007788-09t52zix 43 20 . . . cord-007788-09t52zix 44 1 The the DT cord-007788-09t52zix 44 2 oral oral JJ cord-007788-09t52zix 44 3 care care NN cord-007788-09t52zix 44 4 team team NN cord-007788-09t52zix 44 5 in in IN cord-007788-09t52zix 44 6 the the DT cord-007788-09t52zix 44 7 HSCT HSCT NNP cord-007788-09t52zix 44 8 setting setting NN cord-007788-09t52zix 44 9 includes include VBZ cord-007788-09t52zix 44 10 dental dental JJ cord-007788-09t52zix 44 11 professionals professional NNS cord-007788-09t52zix 44 12 , , , cord-007788-09t52zix 44 13 dietician dietician NN cord-007788-09t52zix 44 14 , , , cord-007788-09t52zix 44 15 nurse nurse NN cord-007788-09t52zix 44 16 , , , cord-007788-09t52zix 44 17 doctor doctor NN cord-007788-09t52zix 44 18 and and CC cord-007788-09t52zix 44 19 pharmacist pharmacist NN cord-007788-09t52zix 44 20 . . . cord-007788-09t52zix 45 1 The the DT cord-007788-09t52zix 45 2 support support NN cord-007788-09t52zix 45 3 provided provide VBN cord-007788-09t52zix 45 4 by by IN cord-007788-09t52zix 45 5 the the DT cord-007788-09t52zix 45 6 team team NN cord-007788-09t52zix 45 7 along along IN cord-007788-09t52zix 45 8 with with IN cord-007788-09t52zix 45 9 good good JJ cord-007788-09t52zix 45 10 communication communication NN cord-007788-09t52zix 45 11 and and CC cord-007788-09t52zix 45 12 the the DT cord-007788-09t52zix 45 13 patient patient NN cord-007788-09t52zix 45 14 at at IN cord-007788-09t52zix 45 15 the the DT cord-007788-09t52zix 45 16 centre centre NN cord-007788-09t52zix 45 17 of of IN cord-007788-09t52zix 45 18 all all DT cord-007788-09t52zix 45 19 care care NN cord-007788-09t52zix 45 20 plans plan NNS cord-007788-09t52zix 45 21 is be VBZ cord-007788-09t52zix 45 22 central central JJ cord-007788-09t52zix 45 23 to to IN cord-007788-09t52zix 45 24 maintaining maintain VBG cord-007788-09t52zix 45 25 patient patient NN cord-007788-09t52zix 45 26 's 's POS cord-007788-09t52zix 45 27 oral oral JJ cord-007788-09t52zix 45 28 health health NN cord-007788-09t52zix 45 29 . . . cord-007788-09t52zix 46 1 All all DT cord-007788-09t52zix 46 2 patients patient NNS cord-007788-09t52zix 46 3 should should MD cord-007788-09t52zix 46 4 be be VB cord-007788-09t52zix 46 5 provided provide VBN cord-007788-09t52zix 46 6 with with IN cord-007788-09t52zix 46 7 clear clear JJ cord-007788-09t52zix 46 8 instructions instruction NNS cord-007788-09t52zix 46 9 and and CC cord-007788-09t52zix 46 10 encouraged encourage VBD cord-007788-09t52zix 46 11 to to TO cord-007788-09t52zix 46 12 maintain maintain VB cord-007788-09t52zix 46 13 good good JJ cord-007788-09t52zix 46 14 oral oral JJ cord-007788-09t52zix 46 15 hygiene hygiene NN cord-007788-09t52zix 46 16 . . . cord-007788-09t52zix 47 1 Education education NN cord-007788-09t52zix 47 2 should should MD cord-007788-09t52zix 47 3 also also RB cord-007788-09t52zix 47 4 include include VB cord-007788-09t52zix 47 5 potential potential JJ cord-007788-09t52zix 47 6 oral oral JJ cord-007788-09t52zix 47 7 complications complication NNS cord-007788-09t52zix 47 8 to to TO cord-007788-09t52zix 47 9 enable enable VB cord-007788-09t52zix 47 10 patients patient NNS cord-007788-09t52zix 47 11 to to TO cord-007788-09t52zix 47 12 identify identify VB cord-007788-09t52zix 47 13 and and CC cord-007788-09t52zix 47 14 report report VB cord-007788-09t52zix 47 15 these these DT cord-007788-09t52zix 47 16 early early JJ cord-007788-09t52zix 47 17 ( ( -LRB- cord-007788-09t52zix 47 18 Clarkson Clarkson NNP cord-007788-09t52zix 47 19 et et NNP cord-007788-09t52zix 47 20 al al NNP cord-007788-09t52zix 47 21 . . NNP cord-007788-09t52zix 47 22 2011 2011 CD cord-007788-09t52zix 47 23 ; ; : cord-007788-09t52zix 47 24 Quinn Quinn NNP cord-007788-09t52zix 47 25 et et NNP cord-007788-09t52zix 47 26 al al NNP cord-007788-09t52zix 47 27 . . NNP cord-007788-09t52zix 47 28 2015 2015 CD cord-007788-09t52zix 47 29 ) ) -RRB- cord-007788-09t52zix 47 30 . . . cord-007788-09t52zix 48 1 All all DT cord-007788-09t52zix 48 2 patients patient NNS cord-007788-09t52zix 48 3 should should MD cord-007788-09t52zix 48 4 receive receive VB cord-007788-09t52zix 48 5 written write VBN cord-007788-09t52zix 48 6 information information NN cord-007788-09t52zix 48 7 , , , cord-007788-09t52zix 48 8 as as RB cord-007788-09t52zix 48 9 well well RB cord-007788-09t52zix 48 10 as as IN cord-007788-09t52zix 48 11 verbal verbal JJ cord-007788-09t52zix 48 12 instruction instruction NN cord-007788-09t52zix 48 13 , , , cord-007788-09t52zix 48 14 about about IN cord-007788-09t52zix 48 15 oral oral JJ cord-007788-09t52zix 48 16 care care NN cord-007788-09t52zix 48 17 as as IN cord-007788-09t52zix 48 18 part part NN cord-007788-09t52zix 48 19 of of IN cord-007788-09t52zix 48 20 the the DT cord-007788-09t52zix 48 21 prevention prevention NN cord-007788-09t52zix 48 22 and and CC cord-007788-09t52zix 48 23 treatment treatment NN cord-007788-09t52zix 48 24 of of IN cord-007788-09t52zix 48 25 oral oral JJ cord-007788-09t52zix 48 26 changes change NNS cord-007788-09t52zix 48 27 . . . cord-007788-09t52zix 49 1 Good good JJ cord-007788-09t52zix 49 2 nutrition nutrition NN cord-007788-09t52zix 49 3 is be VBZ cord-007788-09t52zix 49 4 vital vital JJ cord-007788-09t52zix 49 5 in in IN cord-007788-09t52zix 49 6 helping help VBG cord-007788-09t52zix 49 7 to to TO cord-007788-09t52zix 49 8 fight fight VB cord-007788-09t52zix 49 9 infection infection NN cord-007788-09t52zix 49 10 , , , cord-007788-09t52zix 49 11 maintain maintain VB cord-007788-09t52zix 49 12 mucosal mucosal JJ cord-007788-09t52zix 49 13 integrity integrity NN cord-007788-09t52zix 49 14 , , , cord-007788-09t52zix 49 15 enhance enhance VB cord-007788-09t52zix 49 16 mucosal mucosal JJ cord-007788-09t52zix 49 17 tissue tissue NN cord-007788-09t52zix 49 18 repair repair NN cord-007788-09t52zix 49 19 and and CC cord-007788-09t52zix 49 20 reduce reduce VB cord-007788-09t52zix 49 21 exacerbation exacerbation NN cord-007788-09t52zix 49 22 of of IN cord-007788-09t52zix 49 23 existing exist VBG cord-007788-09t52zix 49 24 mucositis mucositis NNP cord-007788-09t52zix 49 25 . . . cord-007788-09t52zix 50 1 Issues issue NNS cord-007788-09t52zix 50 2 that that WDT cord-007788-09t52zix 50 3 may may MD cord-007788-09t52zix 50 4 affect affect VB cord-007788-09t52zix 50 5 nutrition nutrition NN cord-007788-09t52zix 50 6 such such JJ cord-007788-09t52zix 50 7 as as IN cord-007788-09t52zix 50 8 loss loss NN cord-007788-09t52zix 50 9 of of IN cord-007788-09t52zix 50 10 appetite appetite NN cord-007788-09t52zix 50 11 , , , cord-007788-09t52zix 50 12 taste taste VB cord-007788-09t52zix 50 13 changes change NNS cord-007788-09t52zix 50 14 and and CC cord-007788-09t52zix 50 15 dysphagia dysphagia NN cord-007788-09t52zix 50 16 should should MD cord-007788-09t52zix 50 17 be be VB cord-007788-09t52zix 50 18 addressed address VBN cord-007788-09t52zix 50 19 . . . cord-007788-09t52zix 51 1 There there EX cord-007788-09t52zix 51 2 are be VBP cord-007788-09t52zix 51 3 certain certain JJ cord-007788-09t52zix 51 4 foods food NNS cord-007788-09t52zix 51 5 that that WDT cord-007788-09t52zix 51 6 can can MD cord-007788-09t52zix 51 7 damage damage VB cord-007788-09t52zix 51 8 the the DT cord-007788-09t52zix 51 9 oral oral JJ cord-007788-09t52zix 51 10 mucosa mucosa NN cord-007788-09t52zix 51 11 ; ; : cord-007788-09t52zix 51 12 this this DT cord-007788-09t52zix 51 13 may may MD cord-007788-09t52zix 51 14 include include VB cord-007788-09t52zix 51 15 rough rough JJ cord-007788-09t52zix 51 16 , , , cord-007788-09t52zix 51 17 sharp sharp JJ cord-007788-09t52zix 51 18 and and CC cord-007788-09t52zix 51 19 hard hard JJ cord-007788-09t52zix 51 20 foods food NNS cord-007788-09t52zix 51 21 and and CC cord-007788-09t52zix 51 22 should should MD cord-007788-09t52zix 51 23 be be VB cord-007788-09t52zix 51 24 avoided avoid VBN cord-007788-09t52zix 51 25 . . . cord-007788-09t52zix 52 1 Spicy spicy JJ cord-007788-09t52zix 52 2 , , , cord-007788-09t52zix 52 3 very very RB cord-007788-09t52zix 52 4 salty salty JJ cord-007788-09t52zix 52 5 and and CC cord-007788-09t52zix 52 6 acidic acidic JJ cord-007788-09t52zix 52 7 foods food NNS cord-007788-09t52zix 52 8 may may MD cord-007788-09t52zix 52 9 cause cause VB cord-007788-09t52zix 52 10 mucosal mucosal JJ cord-007788-09t52zix 52 11 irritation irritation NN cord-007788-09t52zix 52 12 but but CC cord-007788-09t52zix 52 13 may may MD cord-007788-09t52zix 52 14 be be VB cord-007788-09t52zix 52 15 preferred prefer VBN cord-007788-09t52zix 52 16 or or CC cord-007788-09t52zix 52 17 tolerated tolerate VBN cord-007788-09t52zix 52 18 by by IN cord-007788-09t52zix 52 19 some some DT cord-007788-09t52zix 52 20 patients patient NNS cord-007788-09t52zix 52 21 . . . cord-007788-09t52zix 53 1 Brushing brushing NN cord-007788-09t52zix 53 2 of of IN cord-007788-09t52zix 53 3 teeth tooth NNS cord-007788-09t52zix 53 4 , , , cord-007788-09t52zix 53 5 gums gum NNS cord-007788-09t52zix 53 6 and and CC cord-007788-09t52zix 53 7 tongue tongue NN cord-007788-09t52zix 53 8 should should MD cord-007788-09t52zix 53 9 be be VB cord-007788-09t52zix 53 10 performed perform VBN cord-007788-09t52zix 53 11 two two CD cord-007788-09t52zix 53 12 to to TO cord-007788-09t52zix 53 13 four four CD cord-007788-09t52zix 53 14 times time NNS cord-007788-09t52zix 53 15 a a DT cord-007788-09t52zix 53 16 day day NN cord-007788-09t52zix 53 17 preferably preferably RB cord-007788-09t52zix 53 18 after after IN cord-007788-09t52zix 53 19 meals meal NNS cord-007788-09t52zix 53 20 and and CC cord-007788-09t52zix 53 21 before before IN cord-007788-09t52zix 53 22 going go VBG cord-007788-09t52zix 53 23 to to IN cord-007788-09t52zix 53 24 bed bed NN cord-007788-09t52zix 53 25 ( ( -LRB- cord-007788-09t52zix 53 26 Peterson Peterson NNP cord-007788-09t52zix 53 27 et et NNP cord-007788-09t52zix 53 28 al al NNP cord-007788-09t52zix 53 29 . . NNP cord-007788-09t52zix 53 30 2015 2015 CD cord-007788-09t52zix 53 31 ) ) -RRB- cord-007788-09t52zix 53 32 . . . cord-007788-09t52zix 54 1 Soft Soft NNP cord-007788-09t52zix 54 2 - - HYPH cord-007788-09t52zix 54 3 bristled bristle VBN cord-007788-09t52zix 54 4 toothbrush toothbrush NN cord-007788-09t52zix 54 5 ( ( -LRB- cord-007788-09t52zix 54 6 manual manual JJ cord-007788-09t52zix 54 7 or or CC cord-007788-09t52zix 54 8 electric electric NN cord-007788-09t52zix 54 9 ) ) -RRB- cord-007788-09t52zix 54 10 is be VBZ cord-007788-09t52zix 54 11 recommended recommend VBN cord-007788-09t52zix 54 12 to to TO cord-007788-09t52zix 54 13 prevent prevent VB cord-007788-09t52zix 54 14 injury injury NN cord-007788-09t52zix 54 15 to to IN cord-007788-09t52zix 54 16 the the DT cord-007788-09t52zix 54 17 oral oral JJ cord-007788-09t52zix 54 18 mucosa mucosa NN cord-007788-09t52zix 54 19 and and CC cord-007788-09t52zix 54 20 must must MD cord-007788-09t52zix 54 21 be be VB cord-007788-09t52zix 54 22 rinsed rinse VBN cord-007788-09t52zix 54 23 thoroughly thoroughly RB cord-007788-09t52zix 54 24 with with IN cord-007788-09t52zix 54 25 water water NN cord-007788-09t52zix 54 26 after after IN cord-007788-09t52zix 54 27 each each DT cord-007788-09t52zix 54 28 use use NN cord-007788-09t52zix 54 29 . . . cord-007788-09t52zix 55 1 If if IN cord-007788-09t52zix 55 2 the the DT cord-007788-09t52zix 55 3 mouth mouth NN cord-007788-09t52zix 55 4 is be VBZ cord-007788-09t52zix 55 5 painful painful JJ cord-007788-09t52zix 55 6 or or CC cord-007788-09t52zix 55 7 patients patient NNS cord-007788-09t52zix 55 8 can can MD cord-007788-09t52zix 55 9 not not RB cord-007788-09t52zix 55 10 open open VB cord-007788-09t52zix 55 11 their -PRON- PRP$ cord-007788-09t52zix 55 12 mouths mouth NNS cord-007788-09t52zix 55 13 fully fully RB cord-007788-09t52zix 55 14 , , , cord-007788-09t52zix 55 15 soft soft JJ cord-007788-09t52zix 55 16 oral oral JJ cord-007788-09t52zix 55 17 sponges sponge NNS cord-007788-09t52zix 55 18 may may MD cord-007788-09t52zix 55 19 be be VB cord-007788-09t52zix 55 20 used use VBN cord-007788-09t52zix 55 21 . . . cord-007788-09t52zix 56 1 To to TO cord-007788-09t52zix 56 2 prevent prevent VB cord-007788-09t52zix 56 3 infections infection NNS cord-007788-09t52zix 56 4 , , , cord-007788-09t52zix 56 5 the the DT cord-007788-09t52zix 56 6 toothbrush toothbrush NN cord-007788-09t52zix 56 7 should should MD cord-007788-09t52zix 56 8 be be VB cord-007788-09t52zix 56 9 stored store VBN cord-007788-09t52zix 56 10 with with IN cord-007788-09t52zix 56 11 the the DT cord-007788-09t52zix 56 12 brush brush NN cord-007788-09t52zix 56 13 head head NN cord-007788-09t52zix 56 14 upwards upwards RB cord-007788-09t52zix 56 15 and and CC cord-007788-09t52zix 56 16 not not RB cord-007788-09t52zix 56 17 soaked soak VBN cord-007788-09t52zix 56 18 in in IN cord-007788-09t52zix 56 19 disinfectant disinfectant NN cord-007788-09t52zix 56 20 solution solution NN cord-007788-09t52zix 56 21 . . . cord-007788-09t52zix 57 1 These these DT cord-007788-09t52zix 57 2 should should MD cord-007788-09t52zix 57 3 also also RB cord-007788-09t52zix 57 4 be be VB cord-007788-09t52zix 57 5 monitored monitor VBN cord-007788-09t52zix 57 6 for for IN cord-007788-09t52zix 57 7 evidence evidence NN cord-007788-09t52zix 57 8 of of IN cord-007788-09t52zix 57 9 fungal fungal JJ cord-007788-09t52zix 57 10 / / SYM cord-007788-09t52zix 57 11 bacterial bacterial JJ cord-007788-09t52zix 57 12 colonisation colonisation NN cord-007788-09t52zix 57 13 . . . cord-007788-09t52zix 58 1 In in IN cord-007788-09t52zix 58 2 order order NN cord-007788-09t52zix 58 3 to to TO cord-007788-09t52zix 58 4 protect protect VB cord-007788-09t52zix 58 5 the the DT cord-007788-09t52zix 58 6 enamel enamel NN cord-007788-09t52zix 58 7 , , , cord-007788-09t52zix 58 8 nonabrasive nonabrasive JJ cord-007788-09t52zix 58 9 toothpaste toothpaste NN cord-007788-09t52zix 58 10 containing contain VBG cord-007788-09t52zix 58 11 mild mild JJ cord-007788-09t52zix 58 12 fluoride fluoride NN cord-007788-09t52zix 58 13 ( ( -LRB- cord-007788-09t52zix 58 14 1000 1000 CD cord-007788-09t52zix 58 15 - - SYM cord-007788-09t52zix 58 16 1500 1500 CD cord-007788-09t52zix 58 17 ppm ppm NN cord-007788-09t52zix 58 18 ) ) -RRB- cord-007788-09t52zix 58 19 should should MD cord-007788-09t52zix 58 20 be be VB cord-007788-09t52zix 58 21 used use VBN cord-007788-09t52zix 58 22 . . . cord-007788-09t52zix 59 1 Daily daily JJ cord-007788-09t52zix 59 2 interdental interdental JJ cord-007788-09t52zix 59 3 cleaning cleaning NN cord-007788-09t52zix 59 4 with with IN cord-007788-09t52zix 59 5 brushes brush NNS cord-007788-09t52zix 59 6 may may MD cord-007788-09t52zix 59 7 reduce reduce VB cord-007788-09t52zix 59 8 plaque plaque NN cord-007788-09t52zix 59 9 formation formation NN cord-007788-09t52zix 59 10 between between IN cord-007788-09t52zix 59 11 the the DT cord-007788-09t52zix 59 12 teeth tooth NNS cord-007788-09t52zix 59 13 ( ( -LRB- cord-007788-09t52zix 59 14 Sambunjak Sambunjak NNP cord-007788-09t52zix 59 15 et et FW cord-007788-09t52zix 59 16 al al NNP cord-007788-09t52zix 59 17 . . NNP cord-007788-09t52zix 59 18 2011 2011 CD cord-007788-09t52zix 59 19 ) ) -RRB- cord-007788-09t52zix 59 20 . . . cord-007788-09t52zix 60 1 However however RB cord-007788-09t52zix 60 2 , , , cord-007788-09t52zix 60 3 the the DT cord-007788-09t52zix 60 4 use use NN cord-007788-09t52zix 60 5 of of IN cord-007788-09t52zix 60 6 interdental interdental JJ cord-007788-09t52zix 60 7 cleaners cleaner NNS cord-007788-09t52zix 60 8 should should MD cord-007788-09t52zix 60 9 be be VB cord-007788-09t52zix 60 10 used use VBN cord-007788-09t52zix 60 11 with with IN cord-007788-09t52zix 60 12 caution caution NN cord-007788-09t52zix 60 13 for for IN cord-007788-09t52zix 60 14 patients patient NNS cord-007788-09t52zix 60 15 with with IN cord-007788-09t52zix 60 16 thrombocytopenia thrombocytopenia NN cord-007788-09t52zix 60 17 or or CC cord-007788-09t52zix 60 18 clotting clotting NN cord-007788-09t52zix 60 19 disorders disorder NNS cord-007788-09t52zix 60 20 . . . cord-007788-09t52zix 61 1 After after IN cord-007788-09t52zix 61 2 each each DT cord-007788-09t52zix 61 3 meal meal NN cord-007788-09t52zix 61 4 , , , cord-007788-09t52zix 61 5 dentures denture NNS cord-007788-09t52zix 61 6 must must MD cord-007788-09t52zix 61 7 be be VB cord-007788-09t52zix 61 8 rinsed rinse VBN cord-007788-09t52zix 61 9 . . . cord-007788-09t52zix 62 1 Thorough thorough JJ cord-007788-09t52zix 62 2 cleaning cleaning NN cord-007788-09t52zix 62 3 by by IN cord-007788-09t52zix 62 4 brushing brush VBG cord-007788-09t52zix 62 5 with with IN cord-007788-09t52zix 62 6 soap soap NN cord-007788-09t52zix 62 7 and and CC cord-007788-09t52zix 62 8 water water NN cord-007788-09t52zix 62 9 should should MD cord-007788-09t52zix 62 10 be be VB cord-007788-09t52zix 62 11 performed perform VBN cord-007788-09t52zix 62 12 at at IN cord-007788-09t52zix 62 13 least least JJS cord-007788-09t52zix 62 14 twice twice PDT cord-007788-09t52zix 62 15 a a DT cord-007788-09t52zix 62 16 day day NN cord-007788-09t52zix 62 17 . . . cord-007788-09t52zix 63 1 Dentures denture NNS cord-007788-09t52zix 63 2 should should MD cord-007788-09t52zix 63 3 be be VB cord-007788-09t52zix 63 4 cleaned clean VBN cord-007788-09t52zix 63 5 , , , cord-007788-09t52zix 63 6 dried dry VBN cord-007788-09t52zix 63 7 and and CC cord-007788-09t52zix 63 8 stored store VBN cord-007788-09t52zix 63 9 in in IN cord-007788-09t52zix 63 10 a a DT cord-007788-09t52zix 63 11 closed closed JJ cord-007788-09t52zix 63 12 container container NN cord-007788-09t52zix 63 13 overnight overnight RB cord-007788-09t52zix 64 1 ( ( -LRB- cord-007788-09t52zix 64 2 Duyck Duyck NNP cord-007788-09t52zix 64 3 et et NNP cord-007788-09t52zix 64 4 al al NNP cord-007788-09t52zix 64 5 . . NNP cord-007788-09t52zix 64 6 2013 2013 CD cord-007788-09t52zix 64 7 ) ) -RRB- cord-007788-09t52zix 64 8 . . . cord-007788-09t52zix 65 1 The the DT cord-007788-09t52zix 65 2 goal goal NN cord-007788-09t52zix 65 3 of of IN cord-007788-09t52zix 65 4 using use VBG cord-007788-09t52zix 65 5 mouthwashes mouthwash NNS cord-007788-09t52zix 65 6 may may MD cord-007788-09t52zix 65 7 include include VB cord-007788-09t52zix 65 8 oral oral JJ cord-007788-09t52zix 65 9 hygiene hygiene NN cord-007788-09t52zix 65 10 , , , cord-007788-09t52zix 65 11 preventing prevent VBG cord-007788-09t52zix 65 12 / / SYM cord-007788-09t52zix 65 13 treating treat VBG cord-007788-09t52zix 65 14 infection infection NN cord-007788-09t52zix 65 15 , , , cord-007788-09t52zix 65 16 moistening moisten VBG cord-007788-09t52zix 65 17 the the DT cord-007788-09t52zix 65 18 oral oral JJ cord-007788-09t52zix 65 19 cavity cavity NN cord-007788-09t52zix 65 20 or or CC cord-007788-09t52zix 65 21 providing provide VBG cord-007788-09t52zix 65 22 pain pain NN cord-007788-09t52zix 65 23 relief relief NN cord-007788-09t52zix 65 24 . . . cord-007788-09t52zix 66 1 As as IN cord-007788-09t52zix 66 2 a a DT cord-007788-09t52zix 66 3 minimum minimum NN cord-007788-09t52zix 66 4 to to TO cord-007788-09t52zix 66 5 keep keep VB cord-007788-09t52zix 66 6 the the DT cord-007788-09t52zix 66 7 mouth mouth NN cord-007788-09t52zix 66 8 clean clean JJ cord-007788-09t52zix 66 9 , , , cord-007788-09t52zix 66 10 bland bland JJ cord-007788-09t52zix 66 11 gargles gargle NNS cord-007788-09t52zix 66 12 and and CC cord-007788-09t52zix 66 13 rinses rinse NNS cord-007788-09t52zix 66 14 with with IN cord-007788-09t52zix 66 15 water water NN cord-007788-09t52zix 66 16 , , , cord-007788-09t52zix 66 17 normal normal JJ cord-007788-09t52zix 66 18 saline saline NN cord-007788-09t52zix 66 19 ( ( -LRB- cord-007788-09t52zix 66 20 0.9 0.9 CD cord-007788-09t52zix 66 21 % % NN cord-007788-09t52zix 66 22 NaCl nacl NN cord-007788-09t52zix 66 23 ) ) -RRB- cord-007788-09t52zix 66 24 and and CC cord-007788-09t52zix 66 25 saltwater saltwater NN cord-007788-09t52zix 66 26 are be VBP cord-007788-09t52zix 66 27 recommended recommend VBN cord-007788-09t52zix 66 28 at at IN cord-007788-09t52zix 66 29 least least JJS cord-007788-09t52zix 66 30 four four CD cord-007788-09t52zix 66 31 times time NNS cord-007788-09t52zix 66 32 a a DT cord-007788-09t52zix 66 33 day day NN cord-007788-09t52zix 66 34 ( ( -LRB- cord-007788-09t52zix 66 35 Lalla Lalla NNP cord-007788-09t52zix 66 36 et et FW cord-007788-09t52zix 66 37 al al NNP cord-007788-09t52zix 66 38 . . . cord-007788-09t52zix 67 1 2014 2014 CD cord-007788-09t52zix 67 2 ; ; : cord-007788-09t52zix 67 3 Quinn Quinn NNP cord-007788-09t52zix 67 4 et et NNP cord-007788-09t52zix 67 5 al al NNP cord-007788-09t52zix 67 6 . . NNP cord-007788-09t52zix 67 7 2015 2015 CD cord-007788-09t52zix 67 8 ) ) -RRB- cord-007788-09t52zix 67 9 . . . cord-007788-09t52zix 68 1 Some some DT cord-007788-09t52zix 68 2 patients patient NNS cord-007788-09t52zix 68 3 will will MD cord-007788-09t52zix 68 4 require require VB cord-007788-09t52zix 68 5 assistance assistance NN cord-007788-09t52zix 68 6 ; ; : cord-007788-09t52zix 68 7 it -PRON- PRP cord-007788-09t52zix 68 8 may may MD cord-007788-09t52zix 68 9 be be VB cord-007788-09t52zix 68 10 necessary necessary JJ cord-007788-09t52zix 68 11 for for IN cord-007788-09t52zix 68 12 healthcare healthcare NN cord-007788-09t52zix 68 13 professionals professional NNS cord-007788-09t52zix 68 14 to to TO cord-007788-09t52zix 68 15 perform perform VB cord-007788-09t52zix 68 16 / / SYM cord-007788-09t52zix 68 17 support support VB cord-007788-09t52zix 68 18 oral oral JJ cord-007788-09t52zix 68 19 care care NN cord-007788-09t52zix 68 20 through through IN cord-007788-09t52zix 68 21 rinsing rinse VBG cord-007788-09t52zix 68 22 with with IN cord-007788-09t52zix 68 23 normal normal JJ cord-007788-09t52zix 68 24 saline saline NN cord-007788-09t52zix 68 25 ( ( -LRB- cord-007788-09t52zix 68 26 0.9 0.9 CD cord-007788-09t52zix 68 27 % % NN cord-007788-09t52zix 68 28 NaCl nacl NN cord-007788-09t52zix 68 29 ) ) -RRB- cord-007788-09t52zix 69 1 ( ( -LRB- cord-007788-09t52zix 69 2 Elad Elad NNP cord-007788-09t52zix 69 3 et et NNP cord-007788-09t52zix 69 4 al al NNP cord-007788-09t52zix 69 5 . . NNP cord-007788-09t52zix 69 6 2015 2015 CD cord-007788-09t52zix 69 7 ) ) -RRB- cord-007788-09t52zix 69 8 , , , cord-007788-09t52zix 69 9 with with IN cord-007788-09t52zix 69 10 or or CC cord-007788-09t52zix 69 11 without without IN cord-007788-09t52zix 69 12 suction suction NN cord-007788-09t52zix 69 13 . . . cord-007788-09t52zix 70 1 Lubricants lubricant NNS cord-007788-09t52zix 70 2 , , , cord-007788-09t52zix 70 3 lip lip NN cord-007788-09t52zix 70 4 balm balm NN cord-007788-09t52zix 70 5 or or CC cord-007788-09t52zix 70 6 lip lip NN cord-007788-09t52zix 70 7 cream cream NN cord-007788-09t52zix 70 8 may may MD cord-007788-09t52zix 70 9 be be VB cord-007788-09t52zix 70 10 used use VBN cord-007788-09t52zix 70 11 to to TO cord-007788-09t52zix 70 12 moisten moisten VB cord-007788-09t52zix 70 13 the the DT cord-007788-09t52zix 70 14 lips lip NNS cord-007788-09t52zix 70 15 . . . cord-007788-09t52zix 71 1 Patients patient NNS cord-007788-09t52zix 71 2 should should MD cord-007788-09t52zix 71 3 maintain maintain VB cord-007788-09t52zix 71 4 adequate adequate JJ cord-007788-09t52zix 71 5 hydration hydration NN cord-007788-09t52zix 71 6 and and CC cord-007788-09t52zix 71 7 drink drink NN cord-007788-09t52zix 71 8 water water NN cord-007788-09t52zix 71 9 frequently frequently RB cord-007788-09t52zix 71 10 to to TO cord-007788-09t52zix 71 11 keep keep VB cord-007788-09t52zix 71 12 the the DT cord-007788-09t52zix 71 13 mouth mouth NN cord-007788-09t52zix 71 14 moist moist JJ cord-007788-09t52zix 71 15 . . . cord-007788-09t52zix 72 1 Several several JJ cord-007788-09t52zix 72 2 factors factor NNS cord-007788-09t52zix 72 3 could could MD cord-007788-09t52zix 72 4 contribute contribute VB cord-007788-09t52zix 72 5 to to IN cord-007788-09t52zix 72 6 dryness dryness NN cord-007788-09t52zix 72 7 such such JJ cord-007788-09t52zix 72 8 as as IN cord-007788-09t52zix 72 9 oxygen oxygen NN cord-007788-09t52zix 72 10 therapy therapy NN cord-007788-09t52zix 72 11 and and CC cord-007788-09t52zix 72 12 supportive supportive JJ cord-007788-09t52zix 72 13 care care NN cord-007788-09t52zix 72 14 medications medication NNS cord-007788-09t52zix 72 15 ( ( -LRB- cord-007788-09t52zix 72 16 e.g. e.g. JJ cord-007788-09t52zix 72 17 antidepressants antidepressant NNS cord-007788-09t52zix 72 18 , , , cord-007788-09t52zix 72 19 antihistamines antihistamine NNS cord-007788-09t52zix 72 20 , , , cord-007788-09t52zix 72 21 sedatives sedative NNS cord-007788-09t52zix 72 22 and and CC cord-007788-09t52zix 72 23 opioids opioid NNS cord-007788-09t52zix 72 24 ) ) -RRB- cord-007788-09t52zix 72 25 . . . cord-007788-09t52zix 73 1 To to TO cord-007788-09t52zix 73 2 keep keep VB cord-007788-09t52zix 73 3 the the DT cord-007788-09t52zix 73 4 oral oral JJ cord-007788-09t52zix 73 5 mucosa mucosa NN cord-007788-09t52zix 73 6 moist moist JJ cord-007788-09t52zix 73 7 , , , cord-007788-09t52zix 73 8 regular regular JJ cord-007788-09t52zix 73 9 sipping sipping NN cord-007788-09t52zix 73 10 or or CC cord-007788-09t52zix 73 11 spraying spray VBG cord-007788-09t52zix 73 12 water water NN cord-007788-09t52zix 73 13 may may MD cord-007788-09t52zix 73 14 help help VB cord-007788-09t52zix 73 15 . . . cord-007788-09t52zix 74 1 Use use NN cord-007788-09t52zix 74 2 of of IN cord-007788-09t52zix 74 3 saline saline NN cord-007788-09t52zix 74 4 sprays spray NNS cord-007788-09t52zix 74 5 and and CC cord-007788-09t52zix 74 6 mouthwashes mouthwash NNS cord-007788-09t52zix 74 7 as as RB cord-007788-09t52zix 74 8 well well RB cord-007788-09t52zix 74 9 as as IN cord-007788-09t52zix 74 10 use use NN cord-007788-09t52zix 74 11 of of IN cord-007788-09t52zix 74 12 saliva saliva NN cord-007788-09t52zix 74 13 substitutes substitute NNS cord-007788-09t52zix 74 14 may may MD cord-007788-09t52zix 74 15 be be VB cord-007788-09t52zix 74 16 used use VBN cord-007788-09t52zix 74 17 . . . cord-007788-09t52zix 75 1 There there EX cord-007788-09t52zix 75 2 is be VBZ cord-007788-09t52zix 75 3 anecdotal anecdotal JJ cord-007788-09t52zix 75 4 evidence evidence NN cord-007788-09t52zix 75 5 that that IN cord-007788-09t52zix 75 6 fresh fresh JJ cord-007788-09t52zix 75 7 pineapple pineapple NN cord-007788-09t52zix 75 8 chunks chunk NNS cord-007788-09t52zix 75 9 may may MD cord-007788-09t52zix 75 10 also also RB cord-007788-09t52zix 75 11 help help VB cord-007788-09t52zix 75 12 stimulate stimulate VB cord-007788-09t52zix 75 13 saliva saliva NN cord-007788-09t52zix 75 14 but but CC cord-007788-09t52zix 75 15 should should MD cord-007788-09t52zix 75 16 be be VB cord-007788-09t52zix 75 17 used use VBN cord-007788-09t52zix 75 18 with with IN cord-007788-09t52zix 75 19 caution caution NN cord-007788-09t52zix 75 20 as as IN cord-007788-09t52zix 75 21 their -PRON- PRP$ cord-007788-09t52zix 75 22 acidity acidity NN cord-007788-09t52zix 75 23 could could MD cord-007788-09t52zix 75 24 irritate irritate VB cord-007788-09t52zix 75 25 the the DT cord-007788-09t52zix 75 26 oral oral JJ cord-007788-09t52zix 75 27 mucosa mucosa NN cord-007788-09t52zix 75 28 and and CC cord-007788-09t52zix 75 29 affect affect VB cord-007788-09t52zix 75 30 the the DT cord-007788-09t52zix 75 31 teeth tooth NNS cord-007788-09t52zix 75 32 ( ( -LRB- cord-007788-09t52zix 75 33 Lalla Lalla NNP cord-007788-09t52zix 75 34 et et FW cord-007788-09t52zix 75 35 al al NNP cord-007788-09t52zix 75 36 . . NNP cord-007788-09t52zix 75 37 2014 2014 CD cord-007788-09t52zix 75 38 ) ) -RRB- cord-007788-09t52zix 75 39 . . . cord-007788-09t52zix 76 1 The the DT cord-007788-09t52zix 76 2 choice choice NN cord-007788-09t52zix 76 3 of of IN cord-007788-09t52zix 76 4 prevention prevention NN cord-007788-09t52zix 76 5 regimens regimen NNS cord-007788-09t52zix 76 6 should should MD cord-007788-09t52zix 76 7 be be VB cord-007788-09t52zix 76 8 guided guide VBN cord-007788-09t52zix 76 9 by by IN cord-007788-09t52zix 76 10 evidence evidence NN cord-007788-09t52zix 76 11 - - HYPH cord-007788-09t52zix 76 12 based base VBN cord-007788-09t52zix 76 13 or or CC cord-007788-09t52zix 76 14 expert expert JJ cord-007788-09t52zix 76 15 opinion opinion NN cord-007788-09t52zix 76 16 interventions intervention NNS cord-007788-09t52zix 76 17 , , , cord-007788-09t52zix 76 18 working work VBG cord-007788-09t52zix 76 19 with with IN cord-007788-09t52zix 76 20 the the DT cord-007788-09t52zix 76 21 individual individual JJ cord-007788-09t52zix 76 22 patient patient NN cord-007788-09t52zix 76 23 and and CC cord-007788-09t52zix 76 24 the the DT cord-007788-09t52zix 76 25 potential potential JJ cord-007788-09t52zix 76 26 risk risk NN cord-007788-09t52zix 76 27 of of IN cord-007788-09t52zix 76 28 oral oral JJ cord-007788-09t52zix 76 29 mucositis mucositis NNP cord-007788-09t52zix 76 30 which which WDT cord-007788-09t52zix 76 31 may may MD cord-007788-09t52zix 76 32 include include VB cord-007788-09t52zix 76 33 the the DT cord-007788-09t52zix 76 34 following follow VBG cord-007788-09t52zix 76 35 ( ( -LRB- cord-007788-09t52zix 76 36 adapted adapt VBN cord-007788-09t52zix 76 37 Quinn Quinn NNP cord-007788-09t52zix 76 38 et et NNP cord-007788-09t52zix 76 39 al al NNP cord-007788-09t52zix 76 40 . . . cord-007788-09t52zix 76 41 2015 2015 CD cord-007788-09t52zix 76 42 _SP cord-007788-09t52zix 77 1 While while IN cord-007788-09t52zix 77 2 good good JJ cord-007788-09t52zix 77 3 oral oral JJ cord-007788-09t52zix 77 4 hygiene hygiene NN cord-007788-09t52zix 77 5 is be VBZ cord-007788-09t52zix 77 6 fundamental fundamental JJ cord-007788-09t52zix 77 7 , , , cord-007788-09t52zix 77 8 antifungal antifungal JJ cord-007788-09t52zix 77 9 and and CC cord-007788-09t52zix 77 10 antiviral antiviral JJ cord-007788-09t52zix 77 11 treatments treatment NNS cord-007788-09t52zix 77 12 will will MD cord-007788-09t52zix 77 13 be be VB cord-007788-09t52zix 77 14 prescribed prescribe VBN cord-007788-09t52zix 77 15 to to TO cord-007788-09t52zix 77 16 reduce reduce VB cord-007788-09t52zix 77 17 infections infection NNS cord-007788-09t52zix 77 18 in in IN cord-007788-09t52zix 77 19 patients patient NNS cord-007788-09t52zix 77 20 in in IN cord-007788-09t52zix 77 21 the the DT cord-007788-09t52zix 77 22 transplant transplant NN cord-007788-09t52zix 77 23 setting setting NN cord-007788-09t52zix 77 24 . . . cord-007788-09t52zix 78 1 Patients patient NNS cord-007788-09t52zix 78 2 should should MD cord-007788-09t52zix 78 3 receive receive VB cord-007788-09t52zix 78 4 an an DT cord-007788-09t52zix 78 5 antifungal antifungal JJ cord-007788-09t52zix 78 6 agent agent NN cord-007788-09t52zix 78 7 given give VBN cord-007788-09t52zix 78 8 orally orally RB cord-007788-09t52zix 78 9 or or CC cord-007788-09t52zix 78 10 intravenously intravenously RB cord-007788-09t52zix 78 11 . . . cord-007788-09t52zix 79 1 Antiviral antiviral JJ cord-007788-09t52zix 79 2 prophylaxis prophylaxis NN cord-007788-09t52zix 79 3 should should MD cord-007788-09t52zix 79 4 also also RB cord-007788-09t52zix 79 5 be be VB cord-007788-09t52zix 79 6 given give VBN cord-007788-09t52zix 79 7 . . . cord-007788-09t52zix 80 1 The the DT cord-007788-09t52zix 80 2 choice choice NN cord-007788-09t52zix 80 3 of of IN cord-007788-09t52zix 80 4 drug drug NN cord-007788-09t52zix 80 5 will will MD cord-007788-09t52zix 80 6 be be VB cord-007788-09t52zix 80 7 dependent dependent JJ cord-007788-09t52zix 80 8 on on IN cord-007788-09t52zix 80 9 local local JJ cord-007788-09t52zix 80 10 policies/ policies/ CD cord-007788-09t52zix 80 11 guidance guidance NN cord-007788-09t52zix 80 12 . . . cord-007788-09t52zix 81 1 All all DT cord-007788-09t52zix 81 2 treatment treatment NN cord-007788-09t52zix 81 3 plans plan NNS cord-007788-09t52zix 81 4 should should MD cord-007788-09t52zix 81 5 be be VB cord-007788-09t52zix 81 6 based base VBN cord-007788-09t52zix 81 7 upon upon IN cord-007788-09t52zix 81 8 the the DT cord-007788-09t52zix 81 9 grading grading NN cord-007788-09t52zix 81 10 of of IN cord-007788-09t52zix 81 11 oral oral JJ cord-007788-09t52zix 81 12 damage damage NN cord-007788-09t52zix 81 13 and and CC cord-007788-09t52zix 81 14 patient patient NN cord-007788-09t52zix 81 15 reports report NNS cord-007788-09t52zix 81 16 ; ; : cord-007788-09t52zix 81 17 these these DT cord-007788-09t52zix 81 18 may may MD cord-007788-09t52zix 81 19 include include VB cord-007788-09t52zix 81 20 the the DT cord-007788-09t52zix 81 21 following following NN cord-007788-09t52zix 81 22 . . . cord-007788-09t52zix 82 1 • • NNP cord-007788-09t52zix 83 1 Once once IN cord-007788-09t52zix 83 2 oral oral JJ cord-007788-09t52zix 83 3 damage damage NN cord-007788-09t52zix 83 4 develops develop VBZ cord-007788-09t52zix 83 5 , , , cord-007788-09t52zix 83 6 patients patient NNS cord-007788-09t52zix 83 7 should should MD cord-007788-09t52zix 83 8 be be VB cord-007788-09t52zix 83 9 supported support VBN cord-007788-09t52zix 83 10 to to TO cord-007788-09t52zix 83 11 continue continue VB cord-007788-09t52zix 83 12 oral oral JJ cord-007788-09t52zix 83 13 care care NN cord-007788-09t52zix 83 14 . . . cord-007788-09t52zix 84 1 • • NNP cord-007788-09t52zix 85 1 Frequency frequency NN cord-007788-09t52zix 85 2 of of IN cord-007788-09t52zix 85 3 oral oral JJ cord-007788-09t52zix 85 4 rinsing rinsing NN cord-007788-09t52zix 85 5 may may MD cord-007788-09t52zix 85 6 be be VB cord-007788-09t52zix 85 7 increased increase VBN cord-007788-09t52zix 85 8 . . . cord-007788-09t52zix 86 1 The the DT cord-007788-09t52zix 86 2 aim aim NN cord-007788-09t52zix 86 3 is be VBZ cord-007788-09t52zix 86 4 to to TO cord-007788-09t52zix 86 5 keep keep VB cord-007788-09t52zix 86 6 the the DT cord-007788-09t52zix 86 7 oral oral JJ cord-007788-09t52zix 86 8 surfaces surface NNS cord-007788-09t52zix 86 9 clean clean JJ cord-007788-09t52zix 86 10 and and CC cord-007788-09t52zix 86 11 moist moist JJ cord-007788-09t52zix 86 12 ( ( -LRB- cord-007788-09t52zix 86 13 Elad Elad NNP cord-007788-09t52zix 86 14 et et NNP cord-007788-09t52zix 86 15 al al NNP cord-007788-09t52zix 86 16 . . NNP cord-007788-09t52zix 86 17 2014 2014 CD cord-007788-09t52zix 86 18 ) ) -RRB- cord-007788-09t52zix 86 19 . . . cord-007788-09t52zix 87 1 • • NNP cord-007788-09t52zix 88 1 Check check VB cord-007788-09t52zix 88 2 for for IN cord-007788-09t52zix 88 3 oral oral JJ cord-007788-09t52zix 88 4 infections infection NNS cord-007788-09t52zix 88 5 , , , cord-007788-09t52zix 88 6 swab swab VB cord-007788-09t52zix 88 7 and and CC cord-007788-09t52zix 88 8 treat treat VB cord-007788-09t52zix 88 9 appropriately appropriately RB cord-007788-09t52zix 88 10 . . . cord-007788-09t52zix 89 1 Review Review NNP cord-007788-09t52zix 89 2 of of IN cord-007788-09t52zix 89 3 antifungal antifungal JJ cord-007788-09t52zix 89 4 treatment treatment NN cord-007788-09t52zix 89 5 , , , cord-007788-09t52zix 89 6 local local JJ cord-007788-09t52zix 89 7 or or CC cord-007788-09t52zix 89 8 systemic systemic JJ cord-007788-09t52zix 89 9 , , , cord-007788-09t52zix 89 10 should should MD cord-007788-09t52zix 89 11 be be VB cord-007788-09t52zix 89 12 administered administer VBN cord-007788-09t52zix 89 13 if if IN cord-007788-09t52zix 89 14 required require VBN cord-007788-09t52zix 89 15 ( ( -LRB- cord-007788-09t52zix 89 16 Watson Watson NNP cord-007788-09t52zix 89 17 et et NNP cord-007788-09t52zix 89 18 al al NNP cord-007788-09t52zix 89 19 . . NNP cord-007788-09t52zix 89 20 2011 2011 CD cord-007788-09t52zix 89 21 ) ) -RRB- cord-007788-09t52zix 89 22 . . . cord-007788-09t52zix 90 1 • • NNP cord-007788-09t52zix 91 1 Dexamethasone dexamethasone NN cord-007788-09t52zix 91 2 containing contain VBG cord-007788-09t52zix 91 3 gels gel NNS cord-007788-09t52zix 91 4 may may MD cord-007788-09t52zix 91 5 be be VB cord-007788-09t52zix 91 6 used use VBN cord-007788-09t52zix 91 7 for for IN cord-007788-09t52zix 91 8 aphthous aphthous JJ cord-007788-09t52zix 91 9 lesions lesion NNS cord-007788-09t52zix 91 10 . . . cord-007788-09t52zix 92 1 • • NNP cord-007788-09t52zix 93 1 Consider consider VB cord-007788-09t52zix 93 2 mucosal mucosal JJ cord-007788-09t52zix 93 3 protectants protectant NNS cord-007788-09t52zix 93 4 ) ) -RRB- cord-007788-09t52zix 93 5 . . . cord-007788-09t52zix 94 1 • • NFP cord-007788-09t52zix 94 2 Dietary dietary JJ cord-007788-09t52zix 94 3 requirements requirement NNS cord-007788-09t52zix 94 4 should should MD cord-007788-09t52zix 94 5 be be VB cord-007788-09t52zix 94 6 assessed assess VBN cord-007788-09t52zix 94 7 and and CC cord-007788-09t52zix 94 8 foods food NNS cord-007788-09t52zix 94 9 causing cause VBG cord-007788-09t52zix 94 10 discomfort discomfort NN cord-007788-09t52zix 94 11 avoided avoid VBN cord-007788-09t52zix 94 12 . . . cord-007788-09t52zix 95 1 • • NNP cord-007788-09t52zix 96 1 Swallowing swallowing NN cord-007788-09t52zix 96 2 problems problem NNS cord-007788-09t52zix 96 3 , , , cord-007788-09t52zix 96 4 malnutrition malnutrition NN cord-007788-09t52zix 96 5 and and CC cord-007788-09t52zix 96 6 weight weight NN cord-007788-09t52zix 96 7 loss loss NN cord-007788-09t52zix 96 8 should should MD cord-007788-09t52zix 96 9 be be VB cord-007788-09t52zix 96 10 monitored monitor VBN cord-007788-09t52zix 96 11 and and CC cord-007788-09t52zix 96 12 patients patient NNS cord-007788-09t52zix 96 13 given give VBN cord-007788-09t52zix 96 14 support support NN cord-007788-09t52zix 96 15 / / SYM cord-007788-09t52zix 96 16 advice advice NN cord-007788-09t52zix 96 17 . . . cord-007788-09t52zix 97 1 Adjustments adjustment NNS cord-007788-09t52zix 97 2 to to IN cord-007788-09t52zix 97 3 food food NN cord-007788-09t52zix 97 4 consistency consistency NN cord-007788-09t52zix 97 5 , , , cord-007788-09t52zix 97 6 methods method NNS cord-007788-09t52zix 97 7 of of IN cord-007788-09t52zix 97 8 intake intake NN cord-007788-09t52zix 97 9 , , , cord-007788-09t52zix 97 10 food food NN cord-007788-09t52zix 97 11 fortification fortification NN cord-007788-09t52zix 97 12 and and CC cord-007788-09t52zix 97 13 methods method NNS cord-007788-09t52zix 97 14 of of IN cord-007788-09t52zix 97 15 intake intake NN cord-007788-09t52zix 97 16 should should MD cord-007788-09t52zix 97 17 be be VB cord-007788-09t52zix 97 18 assessed assess VBN cord-007788-09t52zix 97 19 , , , cord-007788-09t52zix 97 20 support support NN cord-007788-09t52zix 97 21 and and CC cord-007788-09t52zix 97 22 education education NN cord-007788-09t52zix 97 23 offered offer VBN cord-007788-09t52zix 97 24 to to IN cord-007788-09t52zix 97 25 patients patient NNS cord-007788-09t52zix 97 26 . . . cord-007788-09t52zix 98 1 Use use NN cord-007788-09t52zix 98 2 of of IN cord-007788-09t52zix 98 3 supplement supplement NN cord-007788-09t52zix 98 4 drinks drink NNS cord-007788-09t52zix 98 5 , , , cord-007788-09t52zix 98 6 PEG PEG NNP cord-007788-09t52zix 98 7 , , , cord-007788-09t52zix 98 8 RIG rig NN cord-007788-09t52zix 98 9 or or CC cord-007788-09t52zix 98 10 nasogastric nasogastric NN cord-007788-09t52zix 98 11 feeding feeding NN cord-007788-09t52zix 98 12 should should MD cord-007788-09t52zix 98 13 be be VB cord-007788-09t52zix 98 14 considered consider VBN cord-007788-09t52zix 98 15 ) ) -RRB- cord-007788-09t52zix 98 16 . . . cord-007788-09t52zix 99 1 • • NNP cord-007788-09t52zix 100 1 Fluid fluid JJ cord-007788-09t52zix 100 2 intake intake NN cord-007788-09t52zix 100 3 should should MD cord-007788-09t52zix 100 4 be be VB cord-007788-09t52zix 100 5 assessed assess VBN cord-007788-09t52zix 100 6 and and CC cord-007788-09t52zix 100 7 route route NN cord-007788-09t52zix 100 8 of of IN cord-007788-09t52zix 100 9 administration administration NN cord-007788-09t52zix 100 10 of of IN cord-007788-09t52zix 100 11 pain pain NN cord-007788-09t52zix 100 12 relief relief NN cord-007788-09t52zix 100 13 continually continually RB cord-007788-09t52zix 100 14 monitored monitor VBD cord-007788-09t52zix 100 15 . . . cord-007788-09t52zix 101 1 General general JJ cord-007788-09t52zix 101 2 health health NN cord-007788-09t52zix 101 3 problems problem NNS cord-007788-09t52zix 101 4 should should MD cord-007788-09t52zix 101 5 also also RB cord-007788-09t52zix 101 6 be be VB cord-007788-09t52zix 101 7 assessed assess VBN cord-007788-09t52zix 101 8 ( ( -LRB- cord-007788-09t52zix 101 9 swallowing swallowing NN cord-007788-09t52zix 101 10 of of IN cord-007788-09t52zix 101 11 tablets tablet NNS cord-007788-09t52zix 101 12 , , , cord-007788-09t52zix 101 13 decreased decrease VBD cord-007788-09t52zix 101 14 blood blood NN cord-007788-09t52zix 101 15 sugar sugar NN cord-007788-09t52zix 101 16 levels level NNS cord-007788-09t52zix 101 17 and and CC cord-007788-09t52zix 101 18 decreased decrease VBD cord-007788-09t52zix 101 19 blood blood NN cord-007788-09t52zix 101 20 pressure pressure NN cord-007788-09t52zix 101 21 , , , cord-007788-09t52zix 101 22 decreased decrease VBD cord-007788-09t52zix 101 23 renal renal JJ cord-007788-09t52zix 101 24 function function NN cord-007788-09t52zix 101 25 leading lead VBG cord-007788-09t52zix 101 26 to to IN cord-007788-09t52zix 101 27 overdosing overdose VBG cord-007788-09t52zix 101 28 of of IN cord-007788-09t52zix 101 29 substances substance NNS cord-007788-09t52zix 101 30 ) ) -RRB- cord-007788-09t52zix 101 31 . . . cord-007788-09t52zix 102 1 • • NNP cord-007788-09t52zix 102 2 Patients patient NNS cord-007788-09t52zix 102 3 will will MD cord-007788-09t52zix 102 4 need need VB cord-007788-09t52zix 102 5 adequate adequate JJ cord-007788-09t52zix 102 6 pain pain NN cord-007788-09t52zix 102 7 medication medication NN cord-007788-09t52zix 102 8 including include VBG cord-007788-09t52zix 102 9 topical topical JJ cord-007788-09t52zix 102 10 and and CC cord-007788-09t52zix 102 11 systemic systemic JJ cord-007788-09t52zix 102 12 analgesia analgesia NN cord-007788-09t52zix 102 13 such such JJ cord-007788-09t52zix 102 14 as as IN cord-007788-09t52zix 102 15 paracetamol paracetamol NNP cord-007788-09t52zix 102 16 , , , cord-007788-09t52zix 102 17 codeine codeine NN cord-007788-09t52zix 102 18 , , , cord-007788-09t52zix 102 19 morphine morphine NN cord-007788-09t52zix 102 20 rinses rinse NNS cord-007788-09t52zix 102 21 , , , cord-007788-09t52zix 102 22 Benzydamine Benzydamine NNP cord-007788-09t52zix 102 23 mouthwash mouthwash NN cord-007788-09t52zix 102 24 , , , cord-007788-09t52zix 102 25 trimecaine trimecaine NN cord-007788-09t52zix 102 26 and and CC cord-007788-09t52zix 102 27 lidocaine lidocaine NN cord-007788-09t52zix 102 28 . . . cord-007788-09t52zix 103 1 Patients patient NNS cord-007788-09t52zix 103 2 should should MD cord-007788-09t52zix 103 3 be be VB cord-007788-09t52zix 103 4 offered offer VBN cord-007788-09t52zix 103 5 education education NN cord-007788-09t52zix 103 6 on on IN cord-007788-09t52zix 103 7 use use NN cord-007788-09t52zix 103 8 and and CC cord-007788-09t52zix 103 9 possible possible JJ cord-007788-09t52zix 103 10 side side NN cord-007788-09t52zix 103 11 effects effect NNS cord-007788-09t52zix 103 12 including include VBG cord-007788-09t52zix 103 13 numbness numbness NN cord-007788-09t52zix 103 14 of of IN cord-007788-09t52zix 103 15 the the DT cord-007788-09t52zix 103 16 oral oral JJ cord-007788-09t52zix 103 17 mucosa mucosa NN cord-007788-09t52zix 103 18 . . . cord-007788-09t52zix 104 1 • • NNP cord-007788-09t52zix 105 1 Increase increase VB cord-007788-09t52zix 105 2 pain pain NN cord-007788-09t52zix 105 3 medication medication NN cord-007788-09t52zix 105 4 following follow VBG cord-007788-09t52zix 105 5 patient patient NN cord-007788-09t52zix 105 6 needs need NNS cord-007788-09t52zix 106 1 • • NNP cord-007788-09t52zix 106 2 Increase increase VB cord-007788-09t52zix 106 3 nutritional nutritional JJ cord-007788-09t52zix 106 4 support support NN cord-007788-09t52zix 107 1 • • NNP cord-007788-09t52zix 108 1 Increase increase VB cord-007788-09t52zix 108 2 oral oral JJ cord-007788-09t52zix 108 3 rinses rinse NNS cord-007788-09t52zix 108 4 and and CC cord-007788-09t52zix 108 5 care care VB cord-007788-09t52zix 109 1 When when WRB cord-007788-09t52zix 109 2 oral oral JJ cord-007788-09t52zix 109 3 damage damage NN cord-007788-09t52zix 109 4 progresses progress VBZ cord-007788-09t52zix 109 5 , , , cord-007788-09t52zix 109 6 closer close JJR cord-007788-09t52zix 109 7 monitoring monitoring NN cord-007788-09t52zix 109 8 and and CC cord-007788-09t52zix 109 9 support support NN cord-007788-09t52zix 109 10 for for IN cord-007788-09t52zix 109 11 patients patient NNS cord-007788-09t52zix 109 12 is be VBZ cord-007788-09t52zix 109 13 required require VBN cord-007788-09t52zix 109 14 . . . cord-007788-09t52zix 110 1 An an DT cord-007788-09t52zix 110 2 important important JJ cord-007788-09t52zix 110 3 aspect aspect NN cord-007788-09t52zix 110 4 of of IN cord-007788-09t52zix 110 5 care care NN cord-007788-09t52zix 110 6 is be VBZ cord-007788-09t52zix 110 7 to to TO cord-007788-09t52zix 110 8 control control VB cord-007788-09t52zix 110 9 the the DT cord-007788-09t52zix 110 10 pain pain NN cord-007788-09t52zix 110 11 thereby thereby RB cord-007788-09t52zix 110 12 helping help VBG cord-007788-09t52zix 110 13 the the DT cord-007788-09t52zix 110 14 patient patient NN cord-007788-09t52zix 110 15 to to TO cord-007788-09t52zix 110 16 continue continue VB cord-007788-09t52zix 110 17 food food NN cord-007788-09t52zix 110 18 and and CC cord-007788-09t52zix 110 19 fluid fluid NN cord-007788-09t52zix 110 20 intake intake NN cord-007788-09t52zix 110 21 , , , cord-007788-09t52zix 110 22 communication communication NN cord-007788-09t52zix 110 23 and and CC cord-007788-09t52zix 110 24 sleep sleep NN cord-007788-09t52zix 110 25 . . . cord-007788-09t52zix 111 1 For for IN cord-007788-09t52zix 111 2 topical topical JJ cord-007788-09t52zix 111 3 treatment treatment NN cord-007788-09t52zix 111 4 the the DT cord-007788-09t52zix 111 5 use use NN cord-007788-09t52zix 111 6 of of IN cord-007788-09t52zix 111 7 topical topical JJ cord-007788-09t52zix 111 8 analgesics analgesic NNS cord-007788-09t52zix 111 9 can can MD cord-007788-09t52zix 111 10 be be VB cord-007788-09t52zix 111 11 intensified intensify VBN cord-007788-09t52zix 111 12 . . . cord-007788-09t52zix 112 1 There there EX cord-007788-09t52zix 112 2 is be VBZ cord-007788-09t52zix 112 3 insufficient insufficient JJ cord-007788-09t52zix 112 4 evidence evidence NN cord-007788-09t52zix 112 5 that that IN cord-007788-09t52zix 112 6 many many JJ cord-007788-09t52zix 112 7 products product NNS cord-007788-09t52zix 112 8 reduce reduce VBP cord-007788-09t52zix 112 9 the the DT cord-007788-09t52zix 112 10 severity severity NN cord-007788-09t52zix 112 11 of of IN cord-007788-09t52zix 112 12 mucositis mucositis NNP cord-007788-09t52zix 112 13 but but CC cord-007788-09t52zix 112 14 comfort comfort NN cord-007788-09t52zix 112 15 can can MD cord-007788-09t52zix 112 16 be be VB cord-007788-09t52zix 112 17 provided provide VBN cord-007788-09t52zix 112 18 for for IN cord-007788-09t52zix 112 19 the the DT cord-007788-09t52zix 112 20 patient patient NN cord-007788-09t52zix 112 21 by by IN cord-007788-09t52zix 112 22 some some DT cord-007788-09t52zix 112 23 of of IN cord-007788-09t52zix 112 24 these these DT cord-007788-09t52zix 112 25 oral oral JJ cord-007788-09t52zix 112 26 care care NN cord-007788-09t52zix 112 27 products product NNS cord-007788-09t52zix 112 28 . . . cord-007788-09t52zix 113 1 Institutions institution NNS cord-007788-09t52zix 113 2 can can MD cord-007788-09t52zix 113 3 offer offer VB cord-007788-09t52zix 113 4 a a DT cord-007788-09t52zix 113 5 range range NN cord-007788-09t52zix 113 6 of of IN cord-007788-09t52zix 113 7 mouthwashes mouthwash NNS cord-007788-09t52zix 113 8 selecting select VBG cord-007788-09t52zix 113 9 the the DT cord-007788-09t52zix 113 10 most most RBS cord-007788-09t52zix 113 11 appropriate appropriate JJ cord-007788-09t52zix 113 12 for for IN cord-007788-09t52zix 113 13 the the DT cord-007788-09t52zix 113 14 clinical clinical JJ cord-007788-09t52zix 113 15 situation situation NN cord-007788-09t52zix 113 16 and and CC cord-007788-09t52zix 113 17 the the DT cord-007788-09t52zix 113 18 patients patient NNS cord-007788-09t52zix 113 19 trying try VBG cord-007788-09t52zix 113 20 out out RP cord-007788-09t52zix 113 21 which which WDT cord-007788-09t52zix 113 22 one one PRP cord-007788-09t52zix 113 23 works work VBZ cord-007788-09t52zix 113 24 best well RBS cord-007788-09t52zix 113 25 for for IN cord-007788-09t52zix 113 26 them -PRON- PRP cord-007788-09t52zix 113 27 . . . cord-007788-09t52zix 114 1 Generally generally RB cord-007788-09t52zix 114 2 spoken speak VBN cord-007788-09t52zix 114 3 , , , cord-007788-09t52zix 114 4 topical topical JJ cord-007788-09t52zix 114 5 antibacterial antibacterial JJ cord-007788-09t52zix 114 6 substances substance NNS cord-007788-09t52zix 114 7 are be VBP cord-007788-09t52zix 114 8 not not RB cord-007788-09t52zix 114 9 recommended recommend VBN cord-007788-09t52zix 114 10 . . . cord-007788-09t52zix 115 1 The the DT cord-007788-09t52zix 115 2 use use NN cord-007788-09t52zix 115 3 of of IN cord-007788-09t52zix 115 4 oral oral JJ cord-007788-09t52zix 115 5 rinses rinse NNS cord-007788-09t52zix 115 6 , , , cord-007788-09t52zix 115 7 topical topical JJ cord-007788-09t52zix 115 8 gels gel NNS cord-007788-09t52zix 115 9 or or CC cord-007788-09t52zix 115 10 films film NNS cord-007788-09t52zix 115 11 can can MD cord-007788-09t52zix 115 12 be be VB cord-007788-09t52zix 115 13 individually individually RB cord-007788-09t52zix 115 14 considered consider VBN cord-007788-09t52zix 115 15 . . . cord-007788-09t52zix 116 1 Any any DT cord-007788-09t52zix 116 2 with with IN cord-007788-09t52zix 116 3 sufficient sufficient JJ cord-007788-09t52zix 116 4 safety safety NN cord-007788-09t52zix 116 5 and and CC cord-007788-09t52zix 116 6 positive positive JJ cord-007788-09t52zix 116 7 experiences experience NNS cord-007788-09t52zix 116 8 can can MD cord-007788-09t52zix 116 9 be be VB cord-007788-09t52zix 116 10 used use VBN cord-007788-09t52zix 116 11 : : : cord-007788-09t52zix 116 12 Caphosol Caphosol NNP cord-007788-09t52zix 116 13 ® ® NN cord-007788-09t52zix 116 14 , , , cord-007788-09t52zix 116 15 Mugard Mugard NNP cord-007788-09t52zix 116 16 ® ® NNP cord-007788-09t52zix 116 17 , , , cord-007788-09t52zix 116 18 Oralife Oralife NNP cord-007788-09t52zix 116 19 ® ® NNP cord-007788-09t52zix 116 20 , , , cord-007788-09t52zix 116 21 Gelclair Gelclair NNP cord-007788-09t52zix 116 22 ® ® . cord-007788-09t52zix 116 23 and and CC cord-007788-09t52zix 117 1 Episil Episil NNP cord-007788-09t52zix 117 2 ® ® NNP cord-007788-09t52zix 117 3 are be VBP cord-007788-09t52zix 117 4 just just RB cord-007788-09t52zix 117 5 a a DT cord-007788-09t52zix 117 6 few few JJ cord-007788-09t52zix 117 7 of of IN cord-007788-09t52zix 117 8 them -PRON- PRP cord-007788-09t52zix 117 9 . . . cord-007788-09t52zix 118 1 For for IN cord-007788-09t52zix 118 2 systemic systemic JJ cord-007788-09t52zix 118 3 pain pain NN cord-007788-09t52zix 118 4 medication medication NN cord-007788-09t52zix 118 5 , , , cord-007788-09t52zix 118 6 it -PRON- PRP cord-007788-09t52zix 118 7 is be VBZ cord-007788-09t52zix 118 8 useful useful JJ cord-007788-09t52zix 118 9 to to TO cord-007788-09t52zix 118 10 follow follow VB cord-007788-09t52zix 118 11 a a DT cord-007788-09t52zix 118 12 step step NN cord-007788-09t52zix 118 13 - - HYPH cord-007788-09t52zix 118 14 by by IN cord-007788-09t52zix 118 15 - - HYPH cord-007788-09t52zix 118 16 step step NN cord-007788-09t52zix 118 17 increase increase NN cord-007788-09t52zix 118 18 , , , cord-007788-09t52zix 118 19 with with IN cord-007788-09t52zix 118 20 the the DT cord-007788-09t52zix 118 21 aim aim NN cord-007788-09t52zix 118 22 of of IN cord-007788-09t52zix 118 23 the the DT cord-007788-09t52zix 118 24 patient patient NN cord-007788-09t52zix 118 25 becoming become VBG cord-007788-09t52zix 118 26 pain pain NN cord-007788-09t52zix 118 27 - - HYPH cord-007788-09t52zix 118 28 free free JJ cord-007788-09t52zix 118 29 within within IN cord-007788-09t52zix 118 30 24 24 CD cord-007788-09t52zix 118 31 h. h. NN cord-007788-09t52zix 119 1 It -PRON- PRP cord-007788-09t52zix 119 2 can can MD cord-007788-09t52zix 119 3 be be VB cord-007788-09t52zix 119 4 helpful helpful JJ cord-007788-09t52zix 119 5 to to TO cord-007788-09t52zix 119 6 monitor monitor VB cord-007788-09t52zix 119 7 the the DT cord-007788-09t52zix 119 8 efficacy efficacy NN cord-007788-09t52zix 119 9 of of IN cord-007788-09t52zix 119 10 pain pain NN cord-007788-09t52zix 119 11 medication medication NN cord-007788-09t52zix 119 12 with with IN cord-007788-09t52zix 119 13 pain pain NN cord-007788-09t52zix 119 14 assessment assessment NN cord-007788-09t52zix 119 15 tools tool NNS cord-007788-09t52zix 119 16 . . . cord-007788-09t52zix 120 1 Institutions institution NNS cord-007788-09t52zix 120 2 should should MD cord-007788-09t52zix 120 3 follow follow VB cord-007788-09t52zix 120 4 a a DT cord-007788-09t52zix 120 5 standardised standardised JJ cord-007788-09t52zix 120 6 pattern pattern NN cord-007788-09t52zix 120 7 of of IN cord-007788-09t52zix 120 8 pain pain NN cord-007788-09t52zix 120 9 medication medication NN cord-007788-09t52zix 120 10 following follow VBG cord-007788-09t52zix 120 11 the the DT cord-007788-09t52zix 120 12 WHO WHO NNP cord-007788-09t52zix 120 13 recommendations recommendation VBZ cord-007788-09t52zix 120 14 where where WRB cord-007788-09t52zix 120 15 applicable applicable JJ cord-007788-09t52zix 120 16 . . . cord-007788-09t52zix 121 1 In in IN cord-007788-09t52zix 121 2 severe severe JJ cord-007788-09t52zix 121 3 mucositis mucositis NN cord-007788-09t52zix 121 4 , , , cord-007788-09t52zix 121 5 the the DT cord-007788-09t52zix 121 6 use use NN cord-007788-09t52zix 121 7 of of IN cord-007788-09t52zix 121 8 opiates opiate NNS cord-007788-09t52zix 121 9 with with IN cord-007788-09t52zix 121 10 the the DT cord-007788-09t52zix 121 11 optimal optimal JJ cord-007788-09t52zix 121 12 application application NN cord-007788-09t52zix 121 13 route route NN cord-007788-09t52zix 121 14 should should MD cord-007788-09t52zix 121 15 be be VB cord-007788-09t52zix 121 16 considered consider VBN cord-007788-09t52zix 121 17 . . . cord-007788-09t52zix 122 1 The the DT cord-007788-09t52zix 122 2 best good JJS cord-007788-09t52zix 122 3 route route NN cord-007788-09t52zix 122 4 of of IN cord-007788-09t52zix 122 5 application application NN cord-007788-09t52zix 122 6 depends depend VBZ cord-007788-09t52zix 122 7 on on IN cord-007788-09t52zix 122 8 many many JJ cord-007788-09t52zix 122 9 individual individual JJ cord-007788-09t52zix 122 10 and and CC cord-007788-09t52zix 122 11 setting set VBG cord-007788-09t52zix 122 12 factors factor NNS cord-007788-09t52zix 122 13 and and CC cord-007788-09t52zix 122 14 may may MD cord-007788-09t52zix 122 15 be be VB cord-007788-09t52zix 122 16 oral oral JJ cord-007788-09t52zix 122 17 , , , cord-007788-09t52zix 122 18 subcutaneous subcutaneous JJ cord-007788-09t52zix 122 19 , , , cord-007788-09t52zix 122 20 intravenous intravenous JJ cord-007788-09t52zix 122 21 or or CC cord-007788-09t52zix 122 22 transdermal transdermal JJ cord-007788-09t52zix 122 23 with with IN cord-007788-09t52zix 122 24 patches patch NNS cord-007788-09t52zix 122 25 . . . cord-007788-09t52zix 123 1 Patients patient NNS cord-007788-09t52zix 123 2 may may MD cord-007788-09t52zix 123 3 require require VB cord-007788-09t52zix 123 4 a a DT cord-007788-09t52zix 123 5 combination combination NN cord-007788-09t52zix 123 6 of of IN cord-007788-09t52zix 123 7 slow slow RB cord-007788-09t52zix 123 8 - - HYPH cord-007788-09t52zix 123 9 release release NN cord-007788-09t52zix 123 10 and and CC cord-007788-09t52zix 123 11 fast fast RB cord-007788-09t52zix 123 12 - - HYPH cord-007788-09t52zix 123 13 acting act VBG cord-007788-09t52zix 123 14 drugs drug NNS cord-007788-09t52zix 123 15 . . . cord-007788-09t52zix 124 1 Patient Patient NNP cord-007788-09t52zix 124 2 controlled control VBN cord-007788-09t52zix 124 3 analgesia analgesia NN cord-007788-09t52zix 124 4 should should MD cord-007788-09t52zix 124 5 be be VB cord-007788-09t52zix 124 6 considered consider VBN cord-007788-09t52zix 124 7 . . . cord-007788-09t52zix 125 1 Careful careful JJ cord-007788-09t52zix 125 2 monitoring monitoring NN cord-007788-09t52zix 125 3 should should MD cord-007788-09t52zix 125 4 include include VB cord-007788-09t52zix 125 5 pain pain NN cord-007788-09t52zix 125 6 relief relief NN cord-007788-09t52zix 125 7 and and CC cord-007788-09t52zix 125 8 any any DT cord-007788-09t52zix 125 9 potential potential JJ cord-007788-09t52zix 125 10 side side NN cord-007788-09t52zix 125 11 effects effect NNS cord-007788-09t52zix 125 12 , , , cord-007788-09t52zix 125 13 and and CC cord-007788-09t52zix 125 14 including include VBG cord-007788-09t52zix 125 15 family family NN cord-007788-09t52zix 125 16 members member NNS cord-007788-09t52zix 125 17 may may MD cord-007788-09t52zix 125 18 prove prove VB cord-007788-09t52zix 125 19 helpful helpful JJ cord-007788-09t52zix 125 20 to to TO cord-007788-09t52zix 125 21 obtain obtain VB cord-007788-09t52zix 125 22 a a DT cord-007788-09t52zix 125 23 wider wide JJR cord-007788-09t52zix 125 24 view view NN cord-007788-09t52zix 125 25 of of IN cord-007788-09t52zix 125 26 how how WRB cord-007788-09t52zix 125 27 well well RB cord-007788-09t52zix 125 28 the the DT cord-007788-09t52zix 125 29 patient patient NN cord-007788-09t52zix 125 30 copes cope VBZ cord-007788-09t52zix 125 31 outside outside IN cord-007788-09t52zix 125 32 the the DT cord-007788-09t52zix 125 33 treatment treatment NN cord-007788-09t52zix 125 34 unit unit NN cord-007788-09t52zix 125 35 . . . cord-007788-09t52zix 126 1 Bleeding bleed VBG cord-007788-09t52zix 126 2 from from IN cord-007788-09t52zix 126 3 OM OM NNP cord-007788-09t52zix 126 4 Continue continue VB cord-007788-09t52zix 126 5 mouth mouth NN cord-007788-09t52zix 126 6 gargling gargle VBG cord-007788-09t52zix 126 7 . . . cord-007788-09t52zix 127 1 Tranexamic tranexamic JJ cord-007788-09t52zix 127 2 acid acid NN cord-007788-09t52zix 127 3 has have VBZ cord-007788-09t52zix 127 4 been be VBN cord-007788-09t52zix 127 5 widely widely RB cord-007788-09t52zix 127 6 used use VBN cord-007788-09t52zix 127 7 in in IN cord-007788-09t52zix 127 8 oral oral JJ cord-007788-09t52zix 127 9 surgery surgery NN cord-007788-09t52zix 127 10 , , , cord-007788-09t52zix 127 11 and and CC cord-007788-09t52zix 127 12 gargling/ gargling/ NN cord-007788-09t52zix 127 13 swishing swish VBG cord-007788-09t52zix 127 14 with with IN cord-007788-09t52zix 127 15 tranexamic tranexamic JJ cord-007788-09t52zix 127 16 acid acid NN cord-007788-09t52zix 127 17 ( ( -LRB- cord-007788-09t52zix 127 18 500 500 CD cord-007788-09t52zix 127 19 mg mg NN cord-007788-09t52zix 127 20 ) ) -RRB- cord-007788-09t52zix 127 21 as as IN cord-007788-09t52zix 127 22 a a DT cord-007788-09t52zix 127 23 mouthwash mouthwash NN cord-007788-09t52zix 127 24 may may MD cord-007788-09t52zix 127 25 be be VB cord-007788-09t52zix 127 26 worth worth JJ cord-007788-09t52zix 127 27 considering consider VBG cord-007788-09t52zix 128 1 ( ( -LRB- cord-007788-09t52zix 128 2 Watson Watson NNP cord-007788-09t52zix 128 3 et et NNP cord-007788-09t52zix 128 4 al al NNP cord-007788-09t52zix 128 5 . . NNP cord-007788-09t52zix 128 6 2011 2011 CD cord-007788-09t52zix 128 7 ) ) -RRB- cord-007788-09t52zix 128 8 . . . cord-007788-09t52zix 129 1 As as IN cord-007788-09t52zix 129 2 this this DT cord-007788-09t52zix 129 3 may may MD cord-007788-09t52zix 129 4 be be VB cord-007788-09t52zix 129 5 due due JJ cord-007788-09t52zix 129 6 to to IN cord-007788-09t52zix 129 7 or or CC cord-007788-09t52zix 129 8 increased increase VBN cord-007788-09t52zix 129 9 by by IN cord-007788-09t52zix 129 10 concurrent concurrent JJ cord-007788-09t52zix 129 11 mediation mediation NN cord-007788-09t52zix 129 12 , , , cord-007788-09t52zix 129 13 a a DT cord-007788-09t52zix 129 14 review review NN cord-007788-09t52zix 129 15 of of IN cord-007788-09t52zix 129 16 the the DT cord-007788-09t52zix 129 17 patient patient NN cord-007788-09t52zix 129 18 's 's POS cord-007788-09t52zix 129 19 medications medication NNS cord-007788-09t52zix 129 20 is be VBZ cord-007788-09t52zix 129 21 needed need VBN cord-007788-09t52zix 129 22 and and CC cord-007788-09t52zix 129 23 if if IN cord-007788-09t52zix 129 24 possible possible JJ cord-007788-09t52zix 129 25 adjustments adjustment NNS cord-007788-09t52zix 129 26 made make VBN cord-007788-09t52zix 129 27 . . . cord-007788-09t52zix 130 1 Patients patient NNS cord-007788-09t52zix 130 2 should should MD cord-007788-09t52zix 130 3 be be VB cord-007788-09t52zix 130 4 encouraged encourage VBN cord-007788-09t52zix 130 5 to to TO cord-007788-09t52zix 130 6 increase increase VB cord-007788-09t52zix 130 7 sip sip NN cord-007788-09t52zix 130 8 - - HYPH cord-007788-09t52zix 130 9 ping ping NN cord-007788-09t52zix 130 10 of of IN cord-007788-09t52zix 130 11 fluids fluid NNS cord-007788-09t52zix 130 12 . . . cord-007788-09t52zix 131 1 Artificial artificial JJ cord-007788-09t52zix 131 2 saliva saliva NN cord-007788-09t52zix 131 3 , , , cord-007788-09t52zix 131 4 viscous viscous JJ cord-007788-09t52zix 131 5 solutions solution NNS cord-007788-09t52zix 131 6 and and CC cord-007788-09t52zix 131 7 gels gel NNS cord-007788-09t52zix 131 8 to to TO cord-007788-09t52zix 131 9 protect protect VB cord-007788-09t52zix 131 10 and and CC cord-007788-09t52zix 131 11 moisten moisten VB cord-007788-09t52zix 131 12 the the DT cord-007788-09t52zix 131 13 mucosa mucosa NN cord-007788-09t52zix 131 14 should should MD cord-007788-09t52zix 131 15 be be VB cord-007788-09t52zix 131 16 considered consider VBN cord-007788-09t52zix 131 17 ; ; : cord-007788-09t52zix 131 18 patients patient NNS cord-007788-09t52zix 131 19 should should MD cord-007788-09t52zix 131 20 be be VB cord-007788-09t52zix 131 21 counselled counsel VBN cord-007788-09t52zix 131 22 on on IN cord-007788-09t52zix 131 23 correct correct JJ cord-007788-09t52zix 131 24 application application NN cord-007788-09t52zix 131 25 . . . cord-007788-09t52zix 132 1 In in IN cord-007788-09t52zix 132 2 chronic chronic JJ cord-007788-09t52zix 132 3 radiotherapy radiotherapy NN cord-007788-09t52zix 132 4 - - HYPH cord-007788-09t52zix 132 5 related relate VBN cord-007788-09t52zix 132 6 xerostomia xerostomia NN cord-007788-09t52zix 132 7 , , , cord-007788-09t52zix 132 8 pilocarpine pilocarpine NN cord-007788-09t52zix 132 9 should should MD cord-007788-09t52zix 132 10 be be VB cord-007788-09t52zix 132 11 used use VBN cord-007788-09t52zix 132 12 . . . cord-007788-09t52zix 133 1 This this DT cord-007788-09t52zix 133 2 is be VBZ cord-007788-09t52zix 133 3 a a DT cord-007788-09t52zix 133 4 common common JJ cord-007788-09t52zix 133 5 side side NN cord-007788-09t52zix 133 6 effect effect NN cord-007788-09t52zix 133 7 during during IN cord-007788-09t52zix 133 8 and and CC cord-007788-09t52zix 133 9 post post AFX cord-007788-09t52zix 133 10 high high JJ cord-007788-09t52zix 133 11 - - HYPH cord-007788-09t52zix 133 12 dose dose NN cord-007788-09t52zix 133 13 radiotherapy radiotherapy NN cord-007788-09t52zix 133 14 . . . cord-007788-09t52zix 134 1 Patients patient NNS cord-007788-09t52zix 134 2 should should MD cord-007788-09t52zix 134 3 be be VB cord-007788-09t52zix 134 4 given give VBN cord-007788-09t52zix 134 5 helpful helpful JJ cord-007788-09t52zix 134 6 exercises exercise NNS cord-007788-09t52zix 134 7 , , , cord-007788-09t52zix 134 8 and and CC cord-007788-09t52zix 134 9 the the DT cord-007788-09t52zix 134 10 team team NN cord-007788-09t52zix 134 11 may may MD cord-007788-09t52zix 134 12 consider consider VB cord-007788-09t52zix 134 13 mechanical mechanical JJ cord-007788-09t52zix 134 14 devices device NNS cord-007788-09t52zix 134 15 to to TO cord-007788-09t52zix 134 16 help help VB cord-007788-09t52zix 134 17 alleviate alleviate VB cord-007788-09t52zix 134 18 the the DT cord-007788-09t52zix 134 19 problem problem NN cord-007788-09t52zix 134 20 . . . cord-007788-09t52zix 135 1 Oral oral JJ cord-007788-09t52zix 135 2 damage damage NN cord-007788-09t52zix 135 3 may may MD cord-007788-09t52zix 135 4 be be VB cord-007788-09t52zix 135 5 a a DT cord-007788-09t52zix 135 6 hallmark hallmark NN cord-007788-09t52zix 135 7 of of IN cord-007788-09t52zix 135 8 graft graft NN cord-007788-09t52zix 135 9 versus versus IN cord-007788-09t52zix 135 10 host host NN cord-007788-09t52zix 135 11 disease disease NN cord-007788-09t52zix 135 12 ( ( -LRB- cord-007788-09t52zix 135 13 GvHD GvHD NNP cord-007788-09t52zix 135 14 ) ) -RRB- cord-007788-09t52zix 135 15 in in IN cord-007788-09t52zix 135 16 patients patient NNS cord-007788-09t52zix 135 17 following follow VBG cord-007788-09t52zix 135 18 allogeneic allogeneic IN cord-007788-09t52zix 135 19 stem stem NN cord-007788-09t52zix 135 20 cell cell NN cord-007788-09t52zix 135 21 transplantation transplantation NN cord-007788-09t52zix 135 22 , , , cord-007788-09t52zix 135 23 and and CC cord-007788-09t52zix 135 24 the the DT cord-007788-09t52zix 135 25 presence presence NN cord-007788-09t52zix 135 26 of of IN cord-007788-09t52zix 135 27 lichenoid lichenoid NNP cord-007788-09t52zix 135 28 hyperkeratotic hyperkeratotic NNP cord-007788-09t52zix 135 29 plaques plaque NNS cord-007788-09t52zix 135 30 ( ( -LRB- cord-007788-09t52zix 135 31 diagnostic diagnostic JJ cord-007788-09t52zix 135 32 sign sign NN cord-007788-09t52zix 135 33 ) ) -RRB- cord-007788-09t52zix 135 34 , , , cord-007788-09t52zix 135 35 gingivitis gingivitis NN cord-007788-09t52zix 135 36 , , , cord-007788-09t52zix 135 37 mucositis mucositis NNP cord-007788-09t52zix 135 38 , , , cord-007788-09t52zix 135 39 erythema erythema NN cord-007788-09t52zix 135 40 , , , cord-007788-09t52zix 135 41 pain pain NN cord-007788-09t52zix 135 42 , , , cord-007788-09t52zix 135 43 xerostomia xerostomia NN cord-007788-09t52zix 135 44 and and CC cord-007788-09t52zix 135 45 ulcers ulcer NNS cord-007788-09t52zix 135 46 may may MD cord-007788-09t52zix 135 47 indicate indicate VB cord-007788-09t52zix 135 48 GvHD GvHD NNP cord-007788-09t52zix 135 49 . . . cord-007788-09t52zix 136 1 Kuten Kuten NNP cord-007788-09t52zix 136 2 - - HYPH cord-007788-09t52zix 136 3 Shorrer Shorrer NNP cord-007788-09t52zix 136 4 et et NNP cord-007788-09t52zix 136 5 al al NNP cord-007788-09t52zix 136 6 . . . cord-007788-09t52zix 137 1 ( ( -LRB- cord-007788-09t52zix 137 2 2014 2014 CD cord-007788-09t52zix 137 3 ) ) -RRB- cord-007788-09t52zix 137 4 suggest suggest VBP cord-007788-09t52zix 137 5 that that IN cord-007788-09t52zix 137 6 solutions solution NNS cord-007788-09t52zix 137 7 of of IN cord-007788-09t52zix 137 8 dexamethasone dexamethasone NN cord-007788-09t52zix 137 9 or or CC cord-007788-09t52zix 137 10 other other JJ cord-007788-09t52zix 137 11 steroids steroid NNS cord-007788-09t52zix 137 12 are be VBP cord-007788-09t52zix 137 13 used use VBN cord-007788-09t52zix 137 14 as as IN cord-007788-09t52zix 137 15 firstline firstline JJ cord-007788-09t52zix 137 16 treatment treatment NN cord-007788-09t52zix 137 17 ; ; : cord-007788-09t52zix 137 18 second second JJ cord-007788-09t52zix 137 19 - - HYPH cord-007788-09t52zix 137 20 line line NN cord-007788-09t52zix 137 21 may may MD cord-007788-09t52zix 137 22 include include VB cord-007788-09t52zix 137 23 solutions solution NNS cord-007788-09t52zix 137 24 of of IN cord-007788-09t52zix 137 25 steroids steroid NNS cord-007788-09t52zix 137 26 in in IN cord-007788-09t52zix 137 27 combination combination NN cord-007788-09t52zix 137 28 with with IN cord-007788-09t52zix 137 29 other other JJ cord-007788-09t52zix 137 30 immunosuppressant immunosuppressant JJ cord-007788-09t52zix 137 31 drugs drug NNS cord-007788-09t52zix 137 32 . . . cord-007788-09t52zix 138 1 Oral oral JJ cord-007788-09t52zix 138 2 damage damage NN cord-007788-09t52zix 138 3 in in IN cord-007788-09t52zix 138 4 the the DT cord-007788-09t52zix 138 5 HSCT HSCT NNP cord-007788-09t52zix 138 6 will will MD cord-007788-09t52zix 138 7 require require VB cord-007788-09t52zix 138 8 several several JJ cord-007788-09t52zix 138 9 weeks week NNS cord-007788-09t52zix 138 10 / / SYM cord-007788-09t52zix 138 11 months month NNS cord-007788-09t52zix 138 12 to to TO cord-007788-09t52zix 138 13 heal heal VB cord-007788-09t52zix 138 14 , , , cord-007788-09t52zix 138 15 and and CC cord-007788-09t52zix 138 16 patients patient NNS cord-007788-09t52zix 138 17 need need VBP cord-007788-09t52zix 138 18 continuing continue VBG cord-007788-09t52zix 138 19 support support NN cord-007788-09t52zix 138 20 and and CC cord-007788-09t52zix 138 21 care care VB cord-007788-09t52zix 138 22 during during IN cord-007788-09t52zix 138 23 this this DT cord-007788-09t52zix 138 24 period period NN cord-007788-09t52zix 138 25 . . . cord-007788-09t52zix 139 1 Advice advice NN cord-007788-09t52zix 139 2 and and CC cord-007788-09t52zix 139 3 support support NN cord-007788-09t52zix 139 4 by by IN cord-007788-09t52zix 139 5 suitably suitably RB cord-007788-09t52zix 139 6 qualified qualified JJ cord-007788-09t52zix 139 7 health health NN cord-007788-09t52zix 139 8 professional professional NN cord-007788-09t52zix 139 9 should should MD cord-007788-09t52zix 139 10 continue continue VB cord-007788-09t52zix 139 11 during during IN cord-007788-09t52zix 139 12 this this DT cord-007788-09t52zix 139 13 period period NN cord-007788-09t52zix 139 14 . . . cord-007788-09t52zix 140 1 Support support NN cord-007788-09t52zix 140 2 to to TO cord-007788-09t52zix 140 3 manage manage VB cord-007788-09t52zix 140 4 side side NN cord-007788-09t52zix 140 5 effects effect NNS cord-007788-09t52zix 140 6 including include VBG cord-007788-09t52zix 140 7 pain pain NN cord-007788-09t52zix 140 8 and and CC cord-007788-09t52zix 140 9 the the DT cord-007788-09t52zix 140 10 gradual gradual JJ cord-007788-09t52zix 140 11 reduction reduction NN cord-007788-09t52zix 140 12 of of IN cord-007788-09t52zix 140 13 analgesia analgesia NN cord-007788-09t52zix 140 14 is be VBZ cord-007788-09t52zix 140 15 extremely extremely RB cord-007788-09t52zix 140 16 important important JJ cord-007788-09t52zix 140 17 . . . cord-007788-09t52zix 141 1 Chronic chronic JJ cord-007788-09t52zix 141 2 side side NN cord-007788-09t52zix 141 3 effects effect NNS cord-007788-09t52zix 141 4 may may MD cord-007788-09t52zix 141 5 include include VB cord-007788-09t52zix 141 6 dental dental JJ cord-007788-09t52zix 141 7 decay decay NN cord-007788-09t52zix 141 8 , , , cord-007788-09t52zix 141 9 trismus trismus NNP cord-007788-09t52zix 141 10 , , , cord-007788-09t52zix 141 11 fibrosis fibrosis NN cord-007788-09t52zix 141 12 , , , cord-007788-09t52zix 141 13 lymphedema lymphedema NN cord-007788-09t52zix 141 14 , , , cord-007788-09t52zix 141 15 chronic chronic JJ cord-007788-09t52zix 141 16 xerostomia xerostomia NN cord-007788-09t52zix 141 17 and and CC cord-007788-09t52zix 141 18 chronic chronic JJ cord-007788-09t52zix 141 19 pain pain NN cord-007788-09t52zix 141 20 and and CC cord-007788-09t52zix 141 21 will will MD cord-007788-09t52zix 141 22 require require VB cord-007788-09t52zix 141 23 careful careful JJ cord-007788-09t52zix 141 24 management management NN cord-007788-09t52zix 141 25 . . . cord-007788-09t52zix 142 1 All all DT cord-007788-09t52zix 142 2 patients patient NNS cord-007788-09t52zix 142 3 should should MD cord-007788-09t52zix 142 4 be be VB cord-007788-09t52zix 142 5 individually individually RB cord-007788-09t52zix 142 6 assessed assess VBN cord-007788-09t52zix 142 7 and and CC cord-007788-09t52zix 142 8 appropriate appropriate JJ cord-007788-09t52zix 142 9 care care NN cord-007788-09t52zix 142 10 and and CC cord-007788-09t52zix 142 11 treatment treatment NN cord-007788-09t52zix 142 12 given give VBN cord-007788-09t52zix 142 13 . . . cord-007788-09t52zix 143 1 Follow follow VB cord-007788-09t52zix 143 2 - - HYPH cord-007788-09t52zix 143 3 up up RP cord-007788-09t52zix 143 4 care care NN cord-007788-09t52zix 143 5 should should MD cord-007788-09t52zix 143 6 be be VB cord-007788-09t52zix 143 7 planned plan VBN cord-007788-09t52zix 143 8 and and CC cord-007788-09t52zix 143 9 supervised supervise VBN cord-007788-09t52zix 143 10 to to TO cord-007788-09t52zix 143 11 address address VB cord-007788-09t52zix 143 12 longer long JJR cord-007788-09t52zix 143 13 - - HYPH cord-007788-09t52zix 143 14 term term NN cord-007788-09t52zix 143 15 and and CC cord-007788-09t52zix 143 16 late late JJ cord-007788-09t52zix 143 17 complications complication NNS cord-007788-09t52zix 143 18 . . . cord-007788-09t52zix 144 1 The the DT cord-007788-09t52zix 144 2 principles principle NNS cord-007788-09t52zix 144 3 presented present VBN cord-007788-09t52zix 144 4 here here RB cord-007788-09t52zix 144 5 are be VBP cord-007788-09t52zix 144 6 intended intend VBN cord-007788-09t52zix 144 7 as as IN cord-007788-09t52zix 144 8 a a DT cord-007788-09t52zix 144 9 support support NN cord-007788-09t52zix 144 10 and and CC cord-007788-09t52zix 144 11 in in IN cord-007788-09t52zix 144 12 no no DT cord-007788-09t52zix 144 13 way way NN cord-007788-09t52zix 144 14 should should MD cord-007788-09t52zix 144 15 replace replace VB cord-007788-09t52zix 144 16 clinical clinical JJ cord-007788-09t52zix 144 17 decision decision NN cord-007788-09t52zix 144 18 - - HYPH cord-007788-09t52zix 144 19 making make VBG cord-007788-09t52zix 144 20 related relate VBN cord-007788-09t52zix 144 21 to to IN cord-007788-09t52zix 144 22 the the DT cord-007788-09t52zix 144 23 particular particular JJ cord-007788-09t52zix 144 24 patient patient NN cord-007788-09t52zix 144 25 and and CC cord-007788-09t52zix 144 26 clinical clinical JJ cord-007788-09t52zix 144 27 situation situation NN cord-007788-09t52zix 144 28 . . . cord-007788-09t52zix 145 1 Depending depend VBG cord-007788-09t52zix 145 2 on on IN cord-007788-09t52zix 145 3 the the DT cord-007788-09t52zix 145 4 severity severity NN cord-007788-09t52zix 145 5 of of IN cord-007788-09t52zix 145 6 oral oral JJ cord-007788-09t52zix 145 7 complications complication NNS cord-007788-09t52zix 145 8 and and CC cord-007788-09t52zix 145 9 the the DT cord-007788-09t52zix 145 10 impact impact NN cord-007788-09t52zix 145 11 on on IN cord-007788-09t52zix 145 12 the the DT cord-007788-09t52zix 145 13 patient patient NN cord-007788-09t52zix 145 14 , , , cord-007788-09t52zix 145 15 the the DT cord-007788-09t52zix 145 16 team team NN cord-007788-09t52zix 145 17 will will MD cord-007788-09t52zix 145 18 need need VB cord-007788-09t52zix 145 19 to to TO cord-007788-09t52zix 145 20 review review VB cord-007788-09t52zix 145 21 the the DT cord-007788-09t52zix 145 22 plan plan NN cord-007788-09t52zix 145 23 of of IN cord-007788-09t52zix 145 24 care care NN cord-007788-09t52zix 145 25 . . . cord-007788-09t52zix 146 1 Sepsis sepsis NN cord-007788-09t52zix 146 2 and and CC cord-007788-09t52zix 146 3 Principles Principles NNPS cord-007788-09t52zix 146 4 of of IN cord-007788-09t52zix 146 5 Care Care NNP cord-007788-09t52zix 147 1 The the DT cord-007788-09t52zix 147 2 increased increased JJ cord-007788-09t52zix 147 3 risk risk NN cord-007788-09t52zix 147 4 of of IN cord-007788-09t52zix 147 5 infections infection NNS cord-007788-09t52zix 147 6 in in IN cord-007788-09t52zix 147 7 patients patient NNS cord-007788-09t52zix 147 8 undergoing undergo VBG cord-007788-09t52zix 147 9 haematopoietic haematopoietic JJ cord-007788-09t52zix 147 10 stem stem NN cord-007788-09t52zix 147 11 cell cell NN cord-007788-09t52zix 147 12 transplantation transplantation NN cord-007788-09t52zix 147 13 ( ( -LRB- cord-007788-09t52zix 147 14 HSCT HSCT NNP cord-007788-09t52zix 147 15 ) ) -RRB- cord-007788-09t52zix 147 16 is be VBZ cord-007788-09t52zix 147 17 well well RB cord-007788-09t52zix 147 18 known known JJ cord-007788-09t52zix 147 19 , , , cord-007788-09t52zix 147 20 and and CC cord-007788-09t52zix 147 21 infection infection NN cord-007788-09t52zix 147 22 is be VBZ cord-007788-09t52zix 147 23 a a DT cord-007788-09t52zix 147 24 leading leading JJ cord-007788-09t52zix 147 25 cause cause NN cord-007788-09t52zix 147 26 of of IN cord-007788-09t52zix 147 27 morbidity morbidity NN cord-007788-09t52zix 147 28 and and CC cord-007788-09t52zix 147 29 mortality mortality NN cord-007788-09t52zix 147 30 . . . cord-007788-09t52zix 148 1 HSCT HSCT NNP cord-007788-09t52zix 148 2 patients patient NNS cord-007788-09t52zix 148 3 are be VBP cord-007788-09t52zix 148 4 particularly particularly RB cord-007788-09t52zix 148 5 at at IN cord-007788-09t52zix 148 6 risk risk NN cord-007788-09t52zix 148 7 , , , cord-007788-09t52zix 148 8 especially especially RB cord-007788-09t52zix 148 9 during during IN cord-007788-09t52zix 148 10 the the DT cord-007788-09t52zix 148 11 neutropenic neutropenic JJ cord-007788-09t52zix 148 12 period period NN cord-007788-09t52zix 148 13 following follow VBG cord-007788-09t52zix 148 14 the the DT cord-007788-09t52zix 148 15 conditioning conditioning NN cord-007788-09t52zix 148 16 treatment treatment NN cord-007788-09t52zix 148 17 . . . cord-007788-09t52zix 149 1 In in IN cord-007788-09t52zix 149 2 HSCT HSCT NNP cord-007788-09t52zix 149 3 patients patient NNS cord-007788-09t52zix 149 4 , , , cord-007788-09t52zix 149 5 signs sign NNS cord-007788-09t52zix 149 6 and and CC cord-007788-09t52zix 149 7 symptoms symptom NNS cord-007788-09t52zix 149 8 of of IN cord-007788-09t52zix 149 9 sepsis sepsis NN cord-007788-09t52zix 149 10 may may MD cord-007788-09t52zix 149 11 be be VB cord-007788-09t52zix 149 12 subtle subtle JJ cord-007788-09t52zix 149 13 and and CC cord-007788-09t52zix 149 14 difficult difficult JJ cord-007788-09t52zix 149 15 to to TO cord-007788-09t52zix 149 16 recognise recognise VB cord-007788-09t52zix 149 17 due due IN cord-007788-09t52zix 149 18 to to IN cord-007788-09t52zix 149 19 neutropenia neutropenia NN cord-007788-09t52zix 149 20 or or CC cord-007788-09t52zix 149 21 other other JJ cord-007788-09t52zix 149 22 complications complication NNS cord-007788-09t52zix 149 23 of of IN cord-007788-09t52zix 149 24 the the DT cord-007788-09t52zix 149 25 transplant transplant NN cord-007788-09t52zix 149 26 procedure procedure NN cord-007788-09t52zix 149 27 . . . cord-007788-09t52zix 150 1 Preventive preventive JJ cord-007788-09t52zix 150 2 measures measure NNS cord-007788-09t52zix 150 3 should should MD cord-007788-09t52zix 150 4 be be VB cord-007788-09t52zix 150 5 applied apply VBN cord-007788-09t52zix 150 6 , , , cord-007788-09t52zix 150 7 but but CC cord-007788-09t52zix 150 8 vigilance vigilance NN cord-007788-09t52zix 150 9 and and CC cord-007788-09t52zix 150 10 close close JJ cord-007788-09t52zix 150 11 monitoring monitoring NN cord-007788-09t52zix 150 12 of of IN cord-007788-09t52zix 150 13 the the DT cord-007788-09t52zix 150 14 patient patient NN cord-007788-09t52zix 150 15 , , , cord-007788-09t52zix 150 16 strong strong JJ cord-007788-09t52zix 150 17 team team NN cord-007788-09t52zix 150 18 collaboration collaboration NN cord-007788-09t52zix 150 19 and and CC cord-007788-09t52zix 150 20 immediate immediate JJ cord-007788-09t52zix 150 21 action action NN cord-007788-09t52zix 150 22 will will MD cord-007788-09t52zix 150 23 allow allow VB cord-007788-09t52zix 150 24 for for IN cord-007788-09t52zix 150 25 prompt prompt JJ cord-007788-09t52zix 150 26 and and CC cord-007788-09t52zix 150 27 appropriate appropriate JJ cord-007788-09t52zix 150 28 management management NN cord-007788-09t52zix 150 29 of of IN cord-007788-09t52zix 150 30 septic septic JJ cord-007788-09t52zix 150 31 patients patient NNS cord-007788-09t52zix 150 32 . . . cord-007788-09t52zix 151 1 ( ( -LRB- cord-007788-09t52zix 151 2 Singer singer NN cord-007788-09t52zix 151 3 et et NNP cord-007788-09t52zix 151 4 al al NNP cord-007788-09t52zix 151 5 . . . cord-007788-09t52zix 151 6 2016 2016 CD cord-007788-09t52zix 151 7 ) ) -RRB- cord-007788-09t52zix 151 8 , , , cord-007788-09t52zix 151 9 sepsis sepsis NN cord-007788-09t52zix 151 10 can can MD cord-007788-09t52zix 151 11 be be VB cord-007788-09t52zix 151 12 defined define VBN cord-007788-09t52zix 151 13 as as IN cord-007788-09t52zix 151 14 : : : cord-007788-09t52zix 151 15 A a DT cord-007788-09t52zix 151 16 life life NN cord-007788-09t52zix 151 17 - - HYPH cord-007788-09t52zix 151 18 threatening threaten VBG cord-007788-09t52zix 151 19 condition condition NN cord-007788-09t52zix 151 20 caused cause VBN cord-007788-09t52zix 151 21 by by IN cord-007788-09t52zix 151 22 aberrant aberrant JJ cord-007788-09t52zix 151 23 and and CC cord-007788-09t52zix 151 24 dysregulated dysregulated JJ cord-007788-09t52zix 151 25 host host NN cord-007788-09t52zix 151 26 response response NN cord-007788-09t52zix 151 27 to to IN cord-007788-09t52zix 151 28 infection infection NN cord-007788-09t52zix 151 29 . . . cord-007788-09t52zix 152 1 The the DT cord-007788-09t52zix 152 2 pathobiology pathobiology NN cord-007788-09t52zix 152 3 is be VBZ cord-007788-09t52zix 152 4 still still RB cord-007788-09t52zix 152 5 not not RB cord-007788-09t52zix 152 6 completely completely RB cord-007788-09t52zix 152 7 known know VBN cord-007788-09t52zix 152 8 but but CC cord-007788-09t52zix 152 9 the the DT cord-007788-09t52zix 152 10 divergent divergent JJ cord-007788-09t52zix 152 11 infection infection NN cord-007788-09t52zix 152 12 response response NN cord-007788-09t52zix 152 13 injures injure VBZ cord-007788-09t52zix 152 14 the the DT cord-007788-09t52zix 152 15 body body NN cord-007788-09t52zix 152 16 's 's POS cord-007788-09t52zix 152 17 own own JJ cord-007788-09t52zix 152 18 tissues tissue NNS cord-007788-09t52zix 152 19 and and CC cord-007788-09t52zix 152 20 organs organ NNS cord-007788-09t52zix 152 21 and and CC cord-007788-09t52zix 152 22 causes cause VBZ cord-007788-09t52zix 152 23 organ organ NN cord-007788-09t52zix 152 24 dysfunction dysfunction NN cord-007788-09t52zix 152 25 . . . cord-007788-09t52zix 153 1 That that DT cord-007788-09t52zix 153 2 is be VBZ cord-007788-09t52zix 153 3 also also RB cord-007788-09t52zix 153 4 what what WP cord-007788-09t52zix 153 5 differentiates differentiate VBZ cord-007788-09t52zix 153 6 sepsis sepsis NN cord-007788-09t52zix 153 7 from from IN cord-007788-09t52zix 153 8 infection infection NN cord-007788-09t52zix 153 9 in in IN cord-007788-09t52zix 153 10 general general JJ cord-007788-09t52zix 153 11 . . . cord-007788-09t52zix 154 1 Septic septic JJ cord-007788-09t52zix 154 2 shock shock NN cord-007788-09t52zix 154 3 is be VBZ cord-007788-09t52zix 154 4 a a DT cord-007788-09t52zix 154 5 subset subset NN cord-007788-09t52zix 154 6 of of IN cord-007788-09t52zix 154 7 sepsis sepsis NN cord-007788-09t52zix 154 8 in in IN cord-007788-09t52zix 154 9 which which WDT cord-007788-09t52zix 154 10 particularly particularly RB cord-007788-09t52zix 154 11 profound profound JJ cord-007788-09t52zix 154 12 circulatory circulatory JJ cord-007788-09t52zix 154 13 , , , cord-007788-09t52zix 154 14 cellular cellular JJ cord-007788-09t52zix 154 15 and and CC cord-007788-09t52zix 154 16 metabolic metabolic JJ cord-007788-09t52zix 154 17 abnormalities abnormality NNS cord-007788-09t52zix 154 18 are be VBP cord-007788-09t52zix 154 19 associated associate VBN cord-007788-09t52zix 154 20 with with IN cord-007788-09t52zix 154 21 a a DT cord-007788-09t52zix 154 22 greater great JJR cord-007788-09t52zix 154 23 risk risk NN cord-007788-09t52zix 154 24 of of IN cord-007788-09t52zix 154 25 mortality mortality NN cord-007788-09t52zix 154 26 than than IN cord-007788-09t52zix 154 27 with with IN cord-007788-09t52zix 154 28 sepsis sepsis NN cord-007788-09t52zix 154 29 alone alone RB cord-007788-09t52zix 154 30 . . . cord-007788-09t52zix 155 1 The the DT cord-007788-09t52zix 155 2 table table NN cord-007788-09t52zix 155 3 below below RB cord-007788-09t52zix 155 4 has have VBZ cord-007788-09t52zix 155 5 limited limit VBN cord-007788-09t52zix 155 6 clinical clinical JJ cord-007788-09t52zix 155 7 diagnostic diagnostic JJ cord-007788-09t52zix 155 8 relevance relevance NN cord-007788-09t52zix 155 9 but but CC cord-007788-09t52zix 155 10 is be VBZ cord-007788-09t52zix 155 11 a a DT cord-007788-09t52zix 155 12 schematic schematic JJ cord-007788-09t52zix 155 13 description description NN cord-007788-09t52zix 155 14 of of IN cord-007788-09t52zix 155 15 the the DT cord-007788-09t52zix 155 16 evolution evolution NN cord-007788-09t52zix 155 17 from from IN cord-007788-09t52zix 155 18 systemic systemic JJ cord-007788-09t52zix 155 19 inflammatory inflammatory JJ cord-007788-09t52zix 155 20 response response NN cord-007788-09t52zix 155 21 system system NN cord-007788-09t52zix 155 22 ( ( -LRB- cord-007788-09t52zix 155 23 SIRS sirs UH cord-007788-09t52zix 155 24 ) ) -RRB- cord-007788-09t52zix 155 25 to to TO cord-007788-09t52zix 155 26 septic septic JJ cord-007788-09t52zix 155 27 shock shock NN cord-007788-09t52zix 155 28 ( ( -LRB- cord-007788-09t52zix 155 29 Table table NN cord-007788-09t52zix 155 30 9 9 CD cord-007788-09t52zix 155 31 .2 .2 CD cord-007788-09t52zix 155 32 ) ) -RRB- cord-007788-09t52zix 155 33 . . . cord-007788-09t52zix 156 1 It -PRON- PRP cord-007788-09t52zix 156 2 is be VBZ cord-007788-09t52zix 156 3 worth worth JJ cord-007788-09t52zix 156 4 noting note VBG cord-007788-09t52zix 156 5 that that IN cord-007788-09t52zix 156 6 the the DT cord-007788-09t52zix 156 7 symptoms symptom NNS cord-007788-09t52zix 156 8 of of IN cord-007788-09t52zix 156 9 SIRS SIRS NNP cord-007788-09t52zix 156 10 will will MD cord-007788-09t52zix 156 11 not not RB cord-007788-09t52zix 156 12 delineate delineate VB cord-007788-09t52zix 156 13 between between IN cord-007788-09t52zix 156 14 SIRS sirs NN cord-007788-09t52zix 156 15 and and CC cord-007788-09t52zix 156 16 sepsis sepsis NN cord-007788-09t52zix 156 17 itself -PRON- PRP cord-007788-09t52zix 156 18 , , , cord-007788-09t52zix 156 19 and and CC cord-007788-09t52zix 156 20 since since IN cord-007788-09t52zix 156 21 many many JJ cord-007788-09t52zix 156 22 of of IN cord-007788-09t52zix 156 23 the the DT cord-007788-09t52zix 156 24 signs sign NNS cord-007788-09t52zix 156 25 and and CC cord-007788-09t52zix 156 26 symptoms symptom NNS cord-007788-09t52zix 156 27 may may MD cord-007788-09t52zix 156 28 be be VB cord-007788-09t52zix 156 29 present present JJ cord-007788-09t52zix 156 30 in in IN cord-007788-09t52zix 156 31 HSCT HSCT NNP cord-007788-09t52zix 156 32 patients patient NNS cord-007788-09t52zix 156 33 , , , cord-007788-09t52zix 156 34 an an DT cord-007788-09t52zix 156 35 individual individual JJ cord-007788-09t52zix 156 36 assessment assessment NN cord-007788-09t52zix 156 37 , , , cord-007788-09t52zix 156 38 including include VBG cord-007788-09t52zix 156 39 other other JJ cord-007788-09t52zix 156 40 examinations examination NNS cord-007788-09t52zix 156 41 as as RB cord-007788-09t52zix 156 42 well well RB cord-007788-09t52zix 156 43 , , , cord-007788-09t52zix 156 44 needs need VBZ cord-007788-09t52zix 156 45 to to TO cord-007788-09t52zix 156 46 be be VB cord-007788-09t52zix 156 47 performed perform VBN cord-007788-09t52zix 156 48 for for IN cord-007788-09t52zix 156 49 the the DT cord-007788-09t52zix 156 50 diagnosis diagnosis NN cord-007788-09t52zix 156 51 of of IN cord-007788-09t52zix 156 52 sepsis sepsis NN cord-007788-09t52zix 156 53 . . . cord-007788-09t52zix 157 1 The the DT cord-007788-09t52zix 157 2 consequence consequence NN cord-007788-09t52zix 157 3 of of IN cord-007788-09t52zix 157 4 the the DT cord-007788-09t52zix 157 5 inflammatory inflammatory JJ cord-007788-09t52zix 157 6 response response NN cord-007788-09t52zix 157 7 and and CC cord-007788-09t52zix 157 8 evolution evolution NN cord-007788-09t52zix 157 9 of of IN cord-007788-09t52zix 157 10 sepsis sepsis NN cord-007788-09t52zix 157 11 is be VBZ cord-007788-09t52zix 157 12 called call VBN cord-007788-09t52zix 157 13 the the DT cord-007788-09t52zix 157 14 sepsis sepsis NN cord-007788-09t52zix 157 15 cascade cascade NN cord-007788-09t52zix 157 16 and and CC cord-007788-09t52zix 157 17 is be VBZ cord-007788-09t52zix 157 18 illustrated illustrate VBN cord-007788-09t52zix 157 19 in in IN cord-007788-09t52zix 157 20 Fig Fig NNP cord-007788-09t52zix 157 21 . . . cord-007788-09t52zix 158 1 9 9 CD cord-007788-09t52zix 158 2 .1 .1 NNS cord-007788-09t52zix 158 3 . . . cord-007788-09t52zix 158 4 _SP cord-007788-09t52zix 159 1 In in IN cord-007788-09t52zix 159 2 the the DT cord-007788-09t52zix 159 3 early early JJ cord-007788-09t52zix 159 4 phase phase NN cord-007788-09t52zix 159 5 of of IN cord-007788-09t52zix 159 6 HSCT HSCT NNP cord-007788-09t52zix 159 7 , , , cord-007788-09t52zix 159 8 i.e. i.e. FW cord-007788-09t52zix 159 9 day day NN cord-007788-09t52zix 159 10 0 0 CD cord-007788-09t52zix 159 11 to to IN cord-007788-09t52zix 159 12 day day NN cord-007788-09t52zix 159 13 +100 +100 NNS cord-007788-09t52zix 159 14 , , , cord-007788-09t52zix 159 15 the the DT cord-007788-09t52zix 159 16 main main JJ cord-007788-09t52zix 159 17 risk risk NN cord-007788-09t52zix 159 18 factors factor NNS cord-007788-09t52zix 159 19 for for IN cord-007788-09t52zix 159 20 infections infection NNS cord-007788-09t52zix 159 21 are be VBP cord-007788-09t52zix 159 22 ( ( -LRB- cord-007788-09t52zix 159 23 Rovira Rovira NNP cord-007788-09t52zix 159 24 et et FW cord-007788-09t52zix 159 25 al al NNP cord-007788-09t52zix 159 26 . . . cord-007788-09t52zix 160 1 2012 2012 CD cord-007788-09t52zix 161 1 ): ): NNP cord-007788-09t52zix 162 1 A a DT cord-007788-09t52zix 162 2 longer long JJR cord-007788-09t52zix 162 3 period period NN cord-007788-09t52zix 162 4 of of IN cord-007788-09t52zix 162 5 neutropenia neutropenia NN cord-007788-09t52zix 162 6 can can MD cord-007788-09t52zix 162 7 be be VB cord-007788-09t52zix 162 8 expected expect VBN cord-007788-09t52zix 162 9 in in IN cord-007788-09t52zix 162 10 allogeneic allogeneic NN cord-007788-09t52zix 162 11 than than IN cord-007788-09t52zix 162 12 in in IN cord-007788-09t52zix 162 13 autologous autologous JJ cord-007788-09t52zix 162 14 transplant transplant NN cord-007788-09t52zix 162 15 . . . cord-007788-09t52zix 163 1 The the DT cord-007788-09t52zix 163 2 stem stem NN cord-007788-09t52zix 163 3 cell cell NN cord-007788-09t52zix 163 4 source source NN cord-007788-09t52zix 163 5 also also RB cord-007788-09t52zix 163 6 affects affect VBZ cord-007788-09t52zix 163 7 the the DT cord-007788-09t52zix 163 8 length length NN cord-007788-09t52zix 163 9 of of IN cord-007788-09t52zix 163 10 the the DT cord-007788-09t52zix 163 11 neutropenic neutropenic JJ cord-007788-09t52zix 163 12 period period NN cord-007788-09t52zix 163 13 where where WRB cord-007788-09t52zix 163 14 peripheral peripheral JJ cord-007788-09t52zix 163 15 blood blood NN cord-007788-09t52zix 163 16 ( ( -LRB- cord-007788-09t52zix 163 17 PBSC PBSC NNP cord-007788-09t52zix 163 18 ) ) -RRB- cord-007788-09t52zix 163 19 has have VBZ cord-007788-09t52zix 163 20 an an DT cord-007788-09t52zix 163 21 expected expect VBN cord-007788-09t52zix 163 22 neutropenic neutropenic JJ cord-007788-09t52zix 163 23 phase phase NN cord-007788-09t52zix 163 24 of of IN cord-007788-09t52zix 163 25 about about RB cord-007788-09t52zix 163 26 2 2 CD cord-007788-09t52zix 163 27 weeks week NNS cord-007788-09t52zix 163 28 , , , cord-007788-09t52zix 163 29 bone bone NN cord-007788-09t52zix 163 30 marrow marrow NN cord-007788-09t52zix 163 31 ( ( -LRB- cord-007788-09t52zix 163 32 BM BM NNP cord-007788-09t52zix 163 33 ) ) -RRB- cord-007788-09t52zix 163 34 3 3 CD cord-007788-09t52zix 163 35 weeks week NNS cord-007788-09t52zix 163 36 and and CC cord-007788-09t52zix 163 37 cord cord NN cord-007788-09t52zix 163 38 blood blood NN cord-007788-09t52zix 163 39 ( ( -LRB- cord-007788-09t52zix 163 40 CB CB NNP cord-007788-09t52zix 163 41 ) ) -RRB- cord-007788-09t52zix 163 42 4 4 CD cord-007788-09t52zix 163 43 weeks week NNS cord-007788-09t52zix 163 44 . . . cord-007788-09t52zix 164 1 Myeloablative Myeloablative NNP cord-007788-09t52zix 164 2 conditioning conditioning NN cord-007788-09t52zix 164 3 ( ( -LRB- cord-007788-09t52zix 164 4 MAC MAC NNP cord-007788-09t52zix 164 5 ) ) -RRB- cord-007788-09t52zix 164 6 treatment treatment NN cord-007788-09t52zix 164 7 will will MD cord-007788-09t52zix 164 8 cause cause VB cord-007788-09t52zix 164 9 a a DT cord-007788-09t52zix 164 10 longer long RBR cord-007788-09t52zix 164 11 neutropenic neutropenic JJ cord-007788-09t52zix 164 12 phase phase NN cord-007788-09t52zix 164 13 than than IN cord-007788-09t52zix 164 14 reduced reduce VBN cord-007788-09t52zix 164 15 intensity intensity NN cord-007788-09t52zix 164 16 conditioning conditioning NN cord-007788-09t52zix 164 17 ( ( -LRB- cord-007788-09t52zix 164 18 RIC RIC NNP cord-007788-09t52zix 164 19 ) ) -RRB- cord-007788-09t52zix 164 20 . . . cord-007788-09t52zix 165 1 All all DT cord-007788-09t52zix 165 2 kinds kind NNS cord-007788-09t52zix 165 3 of of IN cord-007788-09t52zix 165 4 barrier barrier NN cord-007788-09t52zix 165 5 breakdown breakdown NN cord-007788-09t52zix 165 6 will will MD cord-007788-09t52zix 165 7 increase increase VB cord-007788-09t52zix 165 8 the the DT cord-007788-09t52zix 165 9 infection infection NN cord-007788-09t52zix 165 10 risk risk NN cord-007788-09t52zix 165 11 and and CC cord-007788-09t52zix 165 12 mucositis mucositis NNP cord-007788-09t52zix 166 1 occur occur VBP cord-007788-09t52zix 166 2 in in IN cord-007788-09t52zix 166 3 almost almost RB cord-007788-09t52zix 166 4 all all DT cord-007788-09t52zix 166 5 transplant transplant NN cord-007788-09t52zix 166 6 patients patient NNS cord-007788-09t52zix 166 7 . . . cord-007788-09t52zix 167 1 Skin skin NN cord-007788-09t52zix 167 2 breakdown breakdown NN cord-007788-09t52zix 167 3 can can MD cord-007788-09t52zix 167 4 be be VB cord-007788-09t52zix 167 5 caused cause VBN cord-007788-09t52zix 167 6 by by IN cord-007788-09t52zix 167 7 , , , cord-007788-09t52zix 167 8 e.g. e.g. IN cord-007788-09t52zix 167 9 drugs drug NNS cord-007788-09t52zix 167 10 and and CC cord-007788-09t52zix 167 11 acute acute JJ cord-007788-09t52zix 167 12 graft graft NN cord-007788-09t52zix 167 13 versus versus IN cord-007788-09t52zix 167 14 host host NN cord-007788-09t52zix 167 15 disease disease NN cord-007788-09t52zix 167 16 ( ( -LRB- cord-007788-09t52zix 167 17 aGvHD agvhd NN cord-007788-09t52zix 167 18 ) ) -RRB- cord-007788-09t52zix 167 19 . . . cord-007788-09t52zix 168 1 Indwelling indwell VBG cord-007788-09t52zix 168 2 catheters catheter NNS cord-007788-09t52zix 168 3 such such JJ cord-007788-09t52zix 168 4 as as IN cord-007788-09t52zix 168 5 peripheral peripheral JJ cord-007788-09t52zix 168 6 cannulas cannula NNS cord-007788-09t52zix 168 7 , , , cord-007788-09t52zix 168 8 central central JJ cord-007788-09t52zix 168 9 lines line NNS cord-007788-09t52zix 168 10 , , , cord-007788-09t52zix 168 11 urinary urinary JJ cord-007788-09t52zix 168 12 catheters catheter NNS cord-007788-09t52zix 168 13 and and CC cord-007788-09t52zix 168 14 pyelostomy pyelostomy NN cord-007788-09t52zix 168 15 catheters catheter NNS cord-007788-09t52zix 168 16 are be VBP cord-007788-09t52zix 168 17 a a DT cord-007788-09t52zix 168 18 potential potential JJ cord-007788-09t52zix 168 19 port port NN cord-007788-09t52zix 168 20 of of IN cord-007788-09t52zix 168 21 entry entry NN cord-007788-09t52zix 168 22 for for IN cord-007788-09t52zix 168 23 microorganisms microorganism NNS cord-007788-09t52zix 168 24 into into IN cord-007788-09t52zix 168 25 the the DT cord-007788-09t52zix 168 26 blood blood NN cord-007788-09t52zix 168 27 stream stream NN cord-007788-09t52zix 168 28 . . . cord-007788-09t52zix 169 1 Allogeneic allogeneic NN cord-007788-09t52zix 169 2 transplant transplant NN cord-007788-09t52zix 169 3 is be VBZ cord-007788-09t52zix 169 4 always always RB cord-007788-09t52zix 169 5 followed follow VBN cord-007788-09t52zix 169 6 by by IN cord-007788-09t52zix 169 7 long long RB cord-007788-09t52zix 169 8 - - HYPH cord-007788-09t52zix 169 9 lasting last VBG cord-007788-09t52zix 169 10 immunodeficiency immunodeficiency NN cord-007788-09t52zix 169 11 . . . cord-007788-09t52zix 170 1 Conditioning conditioning NN cord-007788-09t52zix 170 2 treatment treatment NN cord-007788-09t52zix 170 3 may may MD cord-007788-09t52zix 170 4 include include VB cord-007788-09t52zix 170 5 T t NN cord-007788-09t52zix 170 6 - - HYPH cord-007788-09t52zix 170 7 cell cell NN cord-007788-09t52zix 170 8 depleting deplete VBG cord-007788-09t52zix 170 9 agents agent NNS cord-007788-09t52zix 170 10 and and CC cord-007788-09t52zix 170 11 even even RB cord-007788-09t52zix 170 12 non non JJ cord-007788-09t52zix 170 13 - - JJ cord-007788-09t52zix 170 14 myeloablative myeloablative JJ cord-007788-09t52zix 170 15 regimens regimen NNS cord-007788-09t52zix 170 16 cause cause VBP cord-007788-09t52zix 170 17 lymphodepletion lymphodepletion NN cord-007788-09t52zix 170 18 with with IN cord-007788-09t52zix 170 19 prolonged prolonged JJ cord-007788-09t52zix 170 20 periods period NNS cord-007788-09t52zix 170 21 of of IN cord-007788-09t52zix 170 22 immune immune JJ cord-007788-09t52zix 170 23 incompetence incompetence NN cord-007788-09t52zix 170 24 . . . cord-007788-09t52zix 171 1 Donor donor NN cord-007788-09t52zix 171 2 type type NN cord-007788-09t52zix 171 3 and and CC cord-007788-09t52zix 171 4 degree degree NN cord-007788-09t52zix 171 5 of of IN cord-007788-09t52zix 171 6 histocompatibility histocompatibility NN cord-007788-09t52zix 171 7 ( ( -LRB- cord-007788-09t52zix 171 8 human human JJ cord-007788-09t52zix 171 9 leukocyte leukocyte NN cord-007788-09t52zix 171 10 antigen antigen NN cord-007788-09t52zix 171 11 ( ( -LRB- cord-007788-09t52zix 171 12 HLA HLA NNP cord-007788-09t52zix 171 13 ) ) -RRB- cord-007788-09t52zix 171 14 match match NN cord-007788-09t52zix 171 15 ) ) -RRB- cord-007788-09t52zix 171 16 are be VBP cord-007788-09t52zix 171 17 other other JJ cord-007788-09t52zix 171 18 factors factor NNS cord-007788-09t52zix 171 19 that that WDT cord-007788-09t52zix 171 20 influence influence VBP cord-007788-09t52zix 171 21 the the DT cord-007788-09t52zix 171 22 time time NN cord-007788-09t52zix 171 23 to to IN cord-007788-09t52zix 171 24 immune immune JJ cord-007788-09t52zix 171 25 reconstitution reconstitution NN cord-007788-09t52zix 171 26 . . . cord-007788-09t52zix 172 1 Immunosuppression Immunosuppression NNP cord-007788-09t52zix 172 2 for for IN cord-007788-09t52zix 172 3 GvHD GvHD NNP cord-007788-09t52zix 172 4 prophylaxis prophylaxis NN cord-007788-09t52zix 172 5 is be VBZ cord-007788-09t52zix 172 6 necessary necessary JJ cord-007788-09t52zix 172 7 in in IN cord-007788-09t52zix 172 8 allogeneic allogeneic JJ cord-007788-09t52zix 172 9 HSCT HSCT NNP cord-007788-09t52zix 172 10 and and CC cord-007788-09t52zix 172 11 will will MD cord-007788-09t52zix 172 12 delay delay VB cord-007788-09t52zix 172 13 immune immune JJ cord-007788-09t52zix 172 14 reconstitution reconstitution NN cord-007788-09t52zix 172 15 ( ( -LRB- cord-007788-09t52zix 172 16 Toubert Toubert NNP cord-007788-09t52zix 172 17 2012 2012 CD cord-007788-09t52zix 172 18 ) ) -RRB- cord-007788-09t52zix 172 19 . . . cord-007788-09t52zix 173 1 Need need VB cord-007788-09t52zix 173 2 for for IN cord-007788-09t52zix 173 3 immunosuppressive immunosuppressive JJ cord-007788-09t52zix 173 4 treatment treatment NN cord-007788-09t52zix 173 5 will will MD cord-007788-09t52zix 173 6 increase increase VB cord-007788-09t52zix 173 7 the the DT cord-007788-09t52zix 173 8 risk risk NN cord-007788-09t52zix 173 9 for for IN cord-007788-09t52zix 173 10 infections infection NNS cord-007788-09t52zix 173 11 . . . cord-007788-09t52zix 174 1 The the DT cord-007788-09t52zix 174 2 sepsis sepsis NN cord-007788-09t52zix 174 3 cascade cascade NN cord-007788-09t52zix 174 4 starts start VBZ cord-007788-09t52zix 174 5 with with IN cord-007788-09t52zix 174 6 an an DT cord-007788-09t52zix 174 7 inflammatory inflammatory JJ cord-007788-09t52zix 174 8 response response NN cord-007788-09t52zix 174 9 that that WDT cord-007788-09t52zix 174 10 will will MD cord-007788-09t52zix 174 11 cause cause VB cord-007788-09t52zix 174 12 microvascular microvascular JJ cord-007788-09t52zix 174 13 injury injury NN cord-007788-09t52zix 174 14 , , , cord-007788-09t52zix 174 15 vasodilation vasodilation NN cord-007788-09t52zix 174 16 and and CC cord-007788-09t52zix 174 17 tissue tissue NN cord-007788-09t52zix 174 18 hypoxia hypoxia NN cord-007788-09t52zix 174 19 . . . cord-007788-09t52zix 175 1 The the DT cord-007788-09t52zix 175 2 microvascular microvascular JJ cord-007788-09t52zix 175 3 injury injury NN cord-007788-09t52zix 175 4 will will MD cord-007788-09t52zix 175 5 lead lead VB cord-007788-09t52zix 175 6 to to IN cord-007788-09t52zix 175 7 capillary capillary JJ cord-007788-09t52zix 175 8 leak leak NN cord-007788-09t52zix 175 9 resulting result VBG cord-007788-09t52zix 175 10 in in IN cord-007788-09t52zix 175 11 oedema oedema NN cord-007788-09t52zix 175 12 , , , cord-007788-09t52zix 175 13 decreased decrease VBD cord-007788-09t52zix 175 14 urinary urinary JJ cord-007788-09t52zix 175 15 output output NN cord-007788-09t52zix 175 16 , , , cord-007788-09t52zix 175 17 tachycardia tachycardia NN cord-007788-09t52zix 175 18 , , , cord-007788-09t52zix 175 19 with with IN cord-007788-09t52zix 175 20 an an DT cord-007788-09t52zix 175 21 initially initially RB cord-007788-09t52zix 175 22 bounding bound VBG cord-007788-09t52zix 175 23 pulse pulse NN cord-007788-09t52zix 175 24 which which WDT cord-007788-09t52zix 175 25 will will MD cord-007788-09t52zix 175 26 then then RB cord-007788-09t52zix 175 27 become become VB cord-007788-09t52zix 175 28 weaker weak JJR cord-007788-09t52zix 175 29 , , , cord-007788-09t52zix 175 30 and and CC cord-007788-09t52zix 175 31 an an DT cord-007788-09t52zix 175 32 increased increase VBN cord-007788-09t52zix 175 33 respiratory respiratory JJ cord-007788-09t52zix 175 34 rate rate NN cord-007788-09t52zix 175 35 . . . cord-007788-09t52zix 176 1 Hypotension hypotension NN cord-007788-09t52zix 176 2 is be VBZ cord-007788-09t52zix 176 3 another another DT cord-007788-09t52zix 176 4 symptom symptom NN cord-007788-09t52zix 176 5 caused cause VBN cord-007788-09t52zix 176 6 by by IN cord-007788-09t52zix 176 7 both both DT cord-007788-09t52zix 176 8 microvascular microvascular JJ cord-007788-09t52zix 176 9 injury injury NN cord-007788-09t52zix 176 10 and and CC cord-007788-09t52zix 176 11 vasodilation vasodilation NN cord-007788-09t52zix 176 12 . . . cord-007788-09t52zix 177 1 The the DT cord-007788-09t52zix 177 2 vasodilation vasodilation NN cord-007788-09t52zix 177 3 will will MD cord-007788-09t52zix 177 4 also also RB cord-007788-09t52zix 177 5 cause cause VB cord-007788-09t52zix 177 6 decreased decrease VBN cord-007788-09t52zix 177 7 renal renal JJ cord-007788-09t52zix 177 8 blood blood NN cord-007788-09t52zix 177 9 flow flow NN cord-007788-09t52zix 177 10 . . . cord-007788-09t52zix 178 1 The the DT cord-007788-09t52zix 178 2 hypovolemia hypovolemia NN cord-007788-09t52zix 178 3 will will MD cord-007788-09t52zix 178 4 cause cause VB cord-007788-09t52zix 178 5 poor poor JJ cord-007788-09t52zix 178 6 tissue tissue NN cord-007788-09t52zix 178 7 perfusion perfusion NN cord-007788-09t52zix 178 8 causing cause VBG cord-007788-09t52zix 178 9 tissue tissue NN cord-007788-09t52zix 178 10 hypoxia hypoxia NN cord-007788-09t52zix 178 11 with with IN cord-007788-09t52zix 178 12 anaerobic anaerobic JJ cord-007788-09t52zix 178 13 metabolism metabolism NN cord-007788-09t52zix 178 14 . . . cord-007788-09t52zix 179 1 In in IN cord-007788-09t52zix 179 2 this this DT cord-007788-09t52zix 179 3 process process NN cord-007788-09t52zix 179 4 oxygen oxygen NN cord-007788-09t52zix 179 5 and and CC cord-007788-09t52zix 179 6 lactate lactate NN cord-007788-09t52zix 179 7 are be VBP cord-007788-09t52zix 179 8 released release VBN cord-007788-09t52zix 179 9 for for IN cord-007788-09t52zix 179 10 metabolism metabolism NN cord-007788-09t52zix 179 11 and and CC cord-007788-09t52zix 179 12 thus thus RB cord-007788-09t52zix 179 13 causing cause VBG cord-007788-09t52zix 179 14 metabolic metabolic JJ cord-007788-09t52zix 179 15 acidosis acidosis NN cord-007788-09t52zix 179 16 ( ( -LRB- cord-007788-09t52zix 179 17 E e NN cord-007788-09t52zix 179 18 - - JJ cord-007788-09t52zix 179 19 learning learning NN cord-007788-09t52zix 179 20 package package NN cord-007788-09t52zix 179 21 Sepsis sepsis NN cord-007788-09t52zix 179 22 and and CC cord-007788-09t52zix 179 23 Sepsis Sepsis NNP cord-007788-09t52zix 179 24 Six six CD cord-007788-09t52zix 179 25 http://sonet.nottingham.ac.uk/ http://sonet.nottingham.ac.uk/ NN cord-007788-09t52zix 179 26 , , , cord-007788-09t52zix 179 27 2017 2017 CD cord-007788-09t52zix 179 28 ) ) -RRB- cord-007788-09t52zix 180 1 Mucosal Mucosal NNP cord-007788-09t52zix 180 2 or or CC cord-007788-09t52zix 180 3 skin skin NN cord-007788-09t52zix 180 4 barrier barrier NN cord-007788-09t52zix 180 5 breakdown breakdown NN cord-007788-09t52zix 180 6 further further RB cord-007788-09t52zix 180 7 increases increase VBZ cord-007788-09t52zix 180 8 the the DT cord-007788-09t52zix 180 9 risk risk NN cord-007788-09t52zix 180 10 . . . cord-007788-09t52zix 181 1 If if IN cord-007788-09t52zix 181 2 the the DT cord-007788-09t52zix 181 3 patient patient NN cord-007788-09t52zix 181 4 is be VBZ cord-007788-09t52zix 181 5 not not RB cord-007788-09t52zix 181 6 in in IN cord-007788-09t52zix 181 7 remission remission NN cord-007788-09t52zix 181 8 at at IN cord-007788-09t52zix 181 9 HSCT HSCT NNP cord-007788-09t52zix 181 10 , , , cord-007788-09t52zix 181 11 there there EX cord-007788-09t52zix 181 12 is be VBZ cord-007788-09t52zix 181 13 a a DT cord-007788-09t52zix 181 14 greater great JJR cord-007788-09t52zix 181 15 risk risk NN cord-007788-09t52zix 181 16 for for IN cord-007788-09t52zix 181 17 infection infection NN cord-007788-09t52zix 181 18 and and CC cord-007788-09t52zix 181 19 sepsis sepsis NN cord-007788-09t52zix 181 20 . . . cord-007788-09t52zix 182 1 Comorbidity comorbidity NN cord-007788-09t52zix 182 2 , , , cord-007788-09t52zix 182 3 such such JJ cord-007788-09t52zix 182 4 as as IN cord-007788-09t52zix 182 5 diabetes diabetes NN cord-007788-09t52zix 182 6 , , , cord-007788-09t52zix 182 7 is be VBZ cord-007788-09t52zix 182 8 another another DT cord-007788-09t52zix 182 9 risk risk NN cord-007788-09t52zix 182 10 factor factor NN cord-007788-09t52zix 182 11 . . . cord-007788-09t52zix 183 1 The the DT cord-007788-09t52zix 183 2 most most RBS cord-007788-09t52zix 183 3 important important JJ cord-007788-09t52zix 183 4 action action NN cord-007788-09t52zix 183 5 to to TO cord-007788-09t52zix 183 6 prevent prevent VB cord-007788-09t52zix 183 7 infections infection NNS cord-007788-09t52zix 183 8 acquired acquire VBN cord-007788-09t52zix 183 9 by by IN cord-007788-09t52zix 183 10 exogenous exogenous JJ cord-007788-09t52zix 183 11 organisms organism NNS cord-007788-09t52zix 183 12 is be VBZ cord-007788-09t52zix 183 13 good good JJ cord-007788-09t52zix 183 14 hand hand NN cord-007788-09t52zix 183 15 hygiene hygiene NN cord-007788-09t52zix 183 16 performed perform VBN cord-007788-09t52zix 183 17 correctly correctly RB cord-007788-09t52zix 183 18 . . . cord-007788-09t52zix 184 1 All all DT cord-007788-09t52zix 184 2 clinical clinical JJ cord-007788-09t52zix 184 3 staff staff NN cord-007788-09t52zix 184 4 should should MD cord-007788-09t52zix 184 5 also also RB cord-007788-09t52zix 184 6 wear wear VB cord-007788-09t52zix 184 7 a a DT cord-007788-09t52zix 184 8 uniform uniform NN cord-007788-09t52zix 184 9 that that WDT cord-007788-09t52zix 184 10 is be VBZ cord-007788-09t52zix 184 11 clean clean JJ cord-007788-09t52zix 184 12 and and CC cord-007788-09t52zix 184 13 short short JJ cord-007788-09t52zix 184 14 sleeved sleeved NN cord-007788-09t52zix 184 15 . . . cord-007788-09t52zix 185 1 Protective protective JJ cord-007788-09t52zix 185 2 isolation isolation NN cord-007788-09t52zix 185 3 during during IN cord-007788-09t52zix 185 4 the the DT cord-007788-09t52zix 185 5 neutropenic neutropenic JJ cord-007788-09t52zix 185 6 phase phase NN cord-007788-09t52zix 185 7 is be VBZ cord-007788-09t52zix 185 8 recommended recommend VBN cord-007788-09t52zix 185 9 , , , cord-007788-09t52zix 185 10 and and CC cord-007788-09t52zix 185 11 the the DT cord-007788-09t52zix 185 12 patient patient NN cord-007788-09t52zix 185 13 should should MD cord-007788-09t52zix 185 14 not not RB cord-007788-09t52zix 185 15 be be VB cord-007788-09t52zix 185 16 in in IN cord-007788-09t52zix 185 17 contact contact NN cord-007788-09t52zix 185 18 with with IN cord-007788-09t52zix 185 19 any any DT cord-007788-09t52zix 185 20 staff staff NN cord-007788-09t52zix 185 21 or or CC cord-007788-09t52zix 185 22 visitors visitor NNS cord-007788-09t52zix 185 23 with with IN cord-007788-09t52zix 185 24 symptoms symptom NNS cord-007788-09t52zix 185 25 of of IN cord-007788-09t52zix 185 26 infection infection NN cord-007788-09t52zix 185 27 . . . cord-007788-09t52zix 186 1 For for IN cord-007788-09t52zix 186 2 prevention prevention NN cord-007788-09t52zix 186 3 of of IN cord-007788-09t52zix 186 4 endogenous endogenous JJ cord-007788-09t52zix 186 5 infections infection NNS cord-007788-09t52zix 186 6 , , , cord-007788-09t52zix 186 7 oral oral JJ cord-007788-09t52zix 186 8 hygiene hygiene NN cord-007788-09t52zix 186 9 and and CC cord-007788-09t52zix 186 10 skin skin NN cord-007788-09t52zix 186 11 care care NN cord-007788-09t52zix 186 12 to to TO cord-007788-09t52zix 186 13 maintain maintain VB cord-007788-09t52zix 186 14 the the DT cord-007788-09t52zix 186 15 mucosal mucosal NN cord-007788-09t52zix 186 16 and and CC cord-007788-09t52zix 186 17 skin skin NN cord-007788-09t52zix 186 18 barrier barrier NN cord-007788-09t52zix 186 19 and and CC cord-007788-09t52zix 186 20 use use NN cord-007788-09t52zix 186 21 of of IN cord-007788-09t52zix 186 22 prophylactic prophylactic JJ cord-007788-09t52zix 186 23 antibiotics antibiotic NNS cord-007788-09t52zix 186 24 are be VBP cord-007788-09t52zix 186 25 the the DT cord-007788-09t52zix 186 26 most most RBS cord-007788-09t52zix 186 27 important important JJ cord-007788-09t52zix 186 28 actions action NNS cord-007788-09t52zix 186 29 . . . cord-007788-09t52zix 187 1 Correct correct JJ cord-007788-09t52zix 187 2 handling handling NN cord-007788-09t52zix 187 3 of of IN cord-007788-09t52zix 187 4 any any DT cord-007788-09t52zix 187 5 indwelling indwell VBG cord-007788-09t52zix 187 6 catheters catheter NNS cord-007788-09t52zix 187 7 is be VBZ cord-007788-09t52zix 187 8 also also RB cord-007788-09t52zix 187 9 a a DT cord-007788-09t52zix 187 10 key key JJ cord-007788-09t52zix 187 11 nursing nursing NN cord-007788-09t52zix 187 12 responsibility responsibility NN cord-007788-09t52zix 187 13 in in IN cord-007788-09t52zix 187 14 infection infection NN cord-007788-09t52zix 187 15 control control NN cord-007788-09t52zix 187 16 . . . cord-007788-09t52zix 188 1 Other other JJ cord-007788-09t52zix 188 2 areas area NNS cord-007788-09t52zix 188 3 where where WRB cord-007788-09t52zix 188 4 infections infection NNS cord-007788-09t52zix 188 5 can can MD cord-007788-09t52zix 188 6 be be VB cord-007788-09t52zix 188 7 prevented prevent VBN cord-007788-09t52zix 188 8 are be VBP cord-007788-09t52zix 188 9 air air NN cord-007788-09t52zix 188 10 and and CC cord-007788-09t52zix 188 11 water water NN cord-007788-09t52zix 188 12 quality quality NN cord-007788-09t52zix 188 13 , , , cord-007788-09t52zix 188 14 food food NN cord-007788-09t52zix 188 15 hygiene hygiene NN cord-007788-09t52zix 188 16 and and CC cord-007788-09t52zix 188 17 the the DT cord-007788-09t52zix 188 18 environmental environmental JJ cord-007788-09t52zix 188 19 cleaning cleaning NN cord-007788-09t52zix 188 20 . . . cord-007788-09t52zix 189 1 Environmental environmental JJ cord-007788-09t52zix 189 2 cleaning cleaning NN cord-007788-09t52zix 189 3 includes include VBZ cord-007788-09t52zix 189 4 medical medical JJ cord-007788-09t52zix 189 5 equipment equipment NN cord-007788-09t52zix 189 6 as as RB cord-007788-09t52zix 189 7 well well RB cord-007788-09t52zix 189 8 . . . cord-007788-09t52zix 190 1 For for IN cord-007788-09t52zix 190 2 more more RBR cord-007788-09t52zix 190 3 detailed detailed JJ cord-007788-09t52zix 190 4 guidance guidance NN cord-007788-09t52zix 190 5 on on IN cord-007788-09t52zix 190 6 infection infection NN cord-007788-09t52zix 190 7 control control NN cord-007788-09t52zix 190 8 , , , cord-007788-09t52zix 190 9 see see VB cord-007788-09t52zix 190 10 Chap Chap NNP cord-007788-09t52zix 190 11 . . . cord-007788-09t52zix 191 1 7 7 CD cord-007788-09t52zix 191 2 . . . cord-007788-09t52zix 192 1 Routine routine JJ cord-007788-09t52zix 192 2 surveillance surveillance NN cord-007788-09t52zix 192 3 screening screening NN cord-007788-09t52zix 192 4 for for IN cord-007788-09t52zix 192 5 infection infection NN cord-007788-09t52zix 192 6 by by IN cord-007788-09t52zix 192 7 bacterial bacterial JJ cord-007788-09t52zix 192 8 and/or and/or CC cord-007788-09t52zix 192 9 fungal fungal JJ cord-007788-09t52zix 192 10 cultures culture NNS cord-007788-09t52zix 192 11 , , , cord-007788-09t52zix 192 12 i.e. i.e. FW cord-007788-09t52zix 192 13 blood blood NN cord-007788-09t52zix 192 14 , , , cord-007788-09t52zix 192 15 urine urine NN cord-007788-09t52zix 192 16 , , , cord-007788-09t52zix 192 17 faeces faece NNS cord-007788-09t52zix 192 18 , , , cord-007788-09t52zix 192 19 swabs swab NNS cord-007788-09t52zix 192 20 from from IN cord-007788-09t52zix 192 21 nasopharynx nasopharynx NN cord-007788-09t52zix 192 22 and and CC cord-007788-09t52zix 192 23 central central JJ cord-007788-09t52zix 192 24 line line NN cord-007788-09t52zix 192 25 insertion insertion NN cord-007788-09t52zix 192 26 site site NN cord-007788-09t52zix 192 27 and and CC cord-007788-09t52zix 192 28 serum serum NN cord-007788-09t52zix 192 29 galactomannan galactomannan NNP cord-007788-09t52zix 192 30 blood blood NN cord-007788-09t52zix 192 31 test test NN cord-007788-09t52zix 192 32 , , , cord-007788-09t52zix 192 33 may may MD cord-007788-09t52zix 192 34 allow allow VB cord-007788-09t52zix 192 35 for for IN cord-007788-09t52zix 192 36 earlier early JJR cord-007788-09t52zix 192 37 identification identification NN cord-007788-09t52zix 192 38 and and CC cord-007788-09t52zix 192 39 implementation implementation NN cord-007788-09t52zix 192 40 of of IN cord-007788-09t52zix 192 41 therapy therapy NN cord-007788-09t52zix 192 42 , , , cord-007788-09t52zix 192 43 although although IN cord-007788-09t52zix 192 44 the the DT cord-007788-09t52zix 192 45 benefit benefit NN cord-007788-09t52zix 192 46 of of IN cord-007788-09t52zix 192 47 such such JJ cord-007788-09t52zix 192 48 routines routine NNS cord-007788-09t52zix 192 49 can can MD cord-007788-09t52zix 192 50 be be VB cord-007788-09t52zix 192 51 discussed discuss VBN cord-007788-09t52zix 193 1 ( ( -LRB- cord-007788-09t52zix 193 2 Nesher Nesher NNP cord-007788-09t52zix 193 3 et et NNP cord-007788-09t52zix 193 4 al al NNP cord-007788-09t52zix 193 5 . . NNP cord-007788-09t52zix 193 6 2014 2014 CD cord-007788-09t52zix 193 7 ) ) -RRB- cord-007788-09t52zix 193 8 . . . cord-007788-09t52zix 194 1 Regular regular JJ cord-007788-09t52zix 194 2 monitoring monitoring NN cord-007788-09t52zix 194 3 of of IN cord-007788-09t52zix 194 4 blood blood NN cord-007788-09t52zix 194 5 tests test NNS cord-007788-09t52zix 194 6 such such JJ cord-007788-09t52zix 194 7 as as IN cord-007788-09t52zix 194 8 full full JJ cord-007788-09t52zix 194 9 blood blood NN cord-007788-09t52zix 194 10 count count NN cord-007788-09t52zix 194 11 , , , cord-007788-09t52zix 194 12 electrolytes electrolyte NNS cord-007788-09t52zix 194 13 , , , cord-007788-09t52zix 194 14 urea urea NN cord-007788-09t52zix 194 15 and/or and/or CC cord-007788-09t52zix 194 16 creatinine creatinine NN cord-007788-09t52zix 194 17 and and CC cord-007788-09t52zix 194 18 C c NN cord-007788-09t52zix 194 19 - - HYPH cord-007788-09t52zix 194 20 reactive reactive JJ cord-007788-09t52zix 194 21 protein protein NN cord-007788-09t52zix 194 22 ( ( -LRB- cord-007788-09t52zix 194 23 CRP CRP NNP cord-007788-09t52zix 194 24 ) ) -RRB- cord-007788-09t52zix 194 25 may may MD cord-007788-09t52zix 194 26 assist assist VB cord-007788-09t52zix 194 27 in in IN cord-007788-09t52zix 194 28 detecting detect VBG cord-007788-09t52zix 194 29 any any DT cord-007788-09t52zix 194 30 changes change NNS cord-007788-09t52zix 194 31 that that WDT cord-007788-09t52zix 194 32 could could MD cord-007788-09t52zix 194 33 indicate indicate VB cord-007788-09t52zix 194 34 infection infection NN cord-007788-09t52zix 194 35 . . . cord-007788-09t52zix 195 1 Prophylactic prophylactic JJ cord-007788-09t52zix 195 2 antibiotics antibiotic NNS cord-007788-09t52zix 195 3 , , , cord-007788-09t52zix 195 4 e.g. e.g. IN cord-007788-09t52zix 195 5 fluoroquinolones fluoroquinolone NNS cord-007788-09t52zix 195 6 , , , cord-007788-09t52zix 195 7 antifungal antifungal JJ cord-007788-09t52zix 195 8 and and CC cord-007788-09t52zix 195 9 antiviral antiviral JJ cord-007788-09t52zix 195 10 medication medication NN cord-007788-09t52zix 195 11 , , , cord-007788-09t52zix 195 12 will will MD cord-007788-09t52zix 195 13 be be VB cord-007788-09t52zix 195 14 used use VBN cord-007788-09t52zix 195 15 in in IN cord-007788-09t52zix 195 16 most most JJS cord-007788-09t52zix 195 17 HSCT HSCT NNP cord-007788-09t52zix 195 18 patients patient NNS cord-007788-09t52zix 195 19 , , , cord-007788-09t52zix 195 20 at at IN cord-007788-09t52zix 195 21 least least JJS cord-007788-09t52zix 195 22 during during IN cord-007788-09t52zix 195 23 the the DT cord-007788-09t52zix 195 24 neutropenic neutropenic JJ cord-007788-09t52zix 195 25 phase phase NN cord-007788-09t52zix 195 26 . . . cord-007788-09t52zix 196 1 Early early JJ cord-007788-09t52zix 196 2 recognition recognition NN cord-007788-09t52zix 196 3 and and CC cord-007788-09t52zix 196 4 treatment treatment NN cord-007788-09t52zix 196 5 is be VBZ cord-007788-09t52zix 196 6 vital vital JJ cord-007788-09t52zix 196 7 for for IN cord-007788-09t52zix 196 8 a a DT cord-007788-09t52zix 196 9 successful successful JJ cord-007788-09t52zix 196 10 outcome outcome NN cord-007788-09t52zix 196 11 of of IN cord-007788-09t52zix 196 12 sepsis sepsis NN cord-007788-09t52zix 196 13 . . . cord-007788-09t52zix 197 1 Temperature temperature NN cord-007788-09t52zix 197 2 , , , cord-007788-09t52zix 197 3 pulse pulse NN cord-007788-09t52zix 197 4 , , , cord-007788-09t52zix 197 5 blood blood NN cord-007788-09t52zix 197 6 pressure pressure NN cord-007788-09t52zix 197 7 , , , cord-007788-09t52zix 197 8 respirations respiration NNS cord-007788-09t52zix 197 9 and and CC cord-007788-09t52zix 197 10 saturation saturation NN cord-007788-09t52zix 197 11 ( ( -LRB- cord-007788-09t52zix 197 12 vital vital JJ cord-007788-09t52zix 197 13 signs sign NNS cord-007788-09t52zix 197 14 ) ) -RRB- cord-007788-09t52zix 197 15 should should MD cord-007788-09t52zix 197 16 be be VB cord-007788-09t52zix 197 17 frequently frequently RB cord-007788-09t52zix 197 18 monitored monitor VBN cord-007788-09t52zix 197 19 . . . cord-007788-09t52zix 198 1 Signs sign NNS cord-007788-09t52zix 198 2 of of IN cord-007788-09t52zix 198 3 infection infection NN cord-007788-09t52zix 198 4 are be VBP cord-007788-09t52zix 198 5 not not RB cord-007788-09t52zix 198 6 always always RB cord-007788-09t52zix 198 7 obvious obvious JJ cord-007788-09t52zix 198 8 , , , cord-007788-09t52zix 198 9 but but CC cord-007788-09t52zix 198 10 if if IN cord-007788-09t52zix 198 11 the the DT cord-007788-09t52zix 198 12 patient patient NN cord-007788-09t52zix 198 13 has have VBZ cord-007788-09t52zix 198 14 a a DT cord-007788-09t52zix 198 15 temperature temperature NN cord-007788-09t52zix 198 16 ≥38.0 ≥38.0 NNP cord-007788-09t52zix 198 17 ° ° NN cord-007788-09t52zix 198 18 C c NN cord-007788-09t52zix 198 19 , , , cord-007788-09t52zix 198 20 cultures culture NNS cord-007788-09t52zix 198 21 should should MD cord-007788-09t52zix 198 22 be be VB cord-007788-09t52zix 198 23 taken take VBN cord-007788-09t52zix 198 24 , , , cord-007788-09t52zix 198 25 i.v i.v NNP cord-007788-09t52zix 198 26 . . . cord-007788-09t52zix 198 27 antibiotics antibiotic NNS cord-007788-09t52zix 198 28 and and CC cord-007788-09t52zix 198 29 i.v i.v NNP cord-007788-09t52zix 198 30 . . NNP cord-007788-09t52zix 198 31 fluids fluid NNS cord-007788-09t52zix 198 32 started start VBD cord-007788-09t52zix 198 33 or or CC cord-007788-09t52zix 198 34 increased increase VBD cord-007788-09t52zix 198 35 and and CC cord-007788-09t52zix 198 36 oxygen oxygen NN cord-007788-09t52zix 198 37 therapy therapy NN cord-007788-09t52zix 198 38 initiated initiate VBD cord-007788-09t52zix 198 39 . . . cord-007788-09t52zix 199 1 The the DT cord-007788-09t52zix 199 2 goal goal NN cord-007788-09t52zix 199 3 is be VBZ cord-007788-09t52zix 199 4 always always RB cord-007788-09t52zix 199 5 to to TO cord-007788-09t52zix 199 6 start start VB cord-007788-09t52zix 199 7 antibiotic antibiotic JJ cord-007788-09t52zix 199 8 treatment treatment NN cord-007788-09t52zix 199 9 within within IN cord-007788-09t52zix 199 10 1 1 CD cord-007788-09t52zix 199 11 h h NN cord-007788-09t52zix 199 12 from from IN cord-007788-09t52zix 199 13 detection detection NN cord-007788-09t52zix 199 14 of of IN cord-007788-09t52zix 199 15 fever fever NN cord-007788-09t52zix 199 16 ( ( -LRB- cord-007788-09t52zix 199 17 Swedish swedish JJ cord-007788-09t52zix 199 18 " " `` cord-007788-09t52zix 199 19 Pro pro JJ cord-007788-09t52zix 199 20 Sepsis sepsis NN cord-007788-09t52zix 199 21 " " '' cord-007788-09t52zix 199 22 Programme Programme NNP cord-007788-09t52zix 199 23 Group Group NNP cord-007788-09t52zix 199 24 Sepsis Sepsis NNP cord-007788-09t52zix 199 25 2015 2015 CD cord-007788-09t52zix 199 26 ) ) -RRB- cord-007788-09t52zix 199 27 . . . cord-007788-09t52zix 200 1 This this DT cord-007788-09t52zix 200 2 is be VBZ cord-007788-09t52zix 200 3 sometimes sometimes RB cord-007788-09t52zix 200 4 referred refer VBN cord-007788-09t52zix 200 5 to to IN cord-007788-09t52zix 200 6 as as IN cord-007788-09t52zix 200 7 " " `` cord-007788-09t52zix 200 8 the the DT cord-007788-09t52zix 200 9 golden golden JJ cord-007788-09t52zix 200 10 hour hour NN cord-007788-09t52zix 200 11 " " '' cord-007788-09t52zix 200 12 ( ( -LRB- cord-007788-09t52zix 200 13 or or CC cord-007788-09t52zix 200 14 " " `` cord-007788-09t52zix 200 15 door door NN cord-007788-09t52zix 200 16 to to TO cord-007788-09t52zix 200 17 needle needle NN cord-007788-09t52zix 200 18 time time NN cord-007788-09t52zix 200 19 " " '' cord-007788-09t52zix 200 20 for for IN cord-007788-09t52zix 200 21 patients patient NNS cord-007788-09t52zix 200 22 admitted admit VBN cord-007788-09t52zix 200 23 from from IN cord-007788-09t52zix 200 24 outside outside IN cord-007788-09t52zix 200 25 the the DT cord-007788-09t52zix 200 26 hospital hospital NN cord-007788-09t52zix 200 27 ) ) -RRB- cord-007788-09t52zix 200 28 and and CC cord-007788-09t52zix 200 29 is be VBZ cord-007788-09t52zix 200 30 the the DT cord-007788-09t52zix 200 31 most most RBS cord-007788-09t52zix 200 32 critical critical JJ cord-007788-09t52zix 200 33 period period NN cord-007788-09t52zix 200 34 in in IN cord-007788-09t52zix 200 35 the the DT cord-007788-09t52zix 200 36 patient patient NN cord-007788-09t52zix 200 37 's 's POS cord-007788-09t52zix 200 38 survival survival NN cord-007788-09t52zix 200 39 from from IN cord-007788-09t52zix 200 40 sepsis sepsis NN cord-007788-09t52zix 200 41 . . . cord-007788-09t52zix 201 1 Recognising recognise VBG cord-007788-09t52zix 201 2 sepsis sepsis NN cord-007788-09t52zix 201 3 can can MD cord-007788-09t52zix 201 4 be be VB cord-007788-09t52zix 201 5 a a DT cord-007788-09t52zix 201 6 challenge challenge NN cord-007788-09t52zix 201 7 in in IN cord-007788-09t52zix 201 8 HSCT HSCT NNP cord-007788-09t52zix 201 9 patients patient NNS cord-007788-09t52zix 201 10 during during IN cord-007788-09t52zix 201 11 the the DT cord-007788-09t52zix 201 12 immediate immediate JJ cord-007788-09t52zix 201 13 posttransplant posttransplant NN cord-007788-09t52zix 201 14 period period NN cord-007788-09t52zix 201 15 where where WRB cord-007788-09t52zix 201 16 often often RB cord-007788-09t52zix 201 17 a a DT cord-007788-09t52zix 201 18 plethora plethora NN cord-007788-09t52zix 201 19 of of IN cord-007788-09t52zix 201 20 symptoms symptom NNS cord-007788-09t52zix 201 21 are be VBP cord-007788-09t52zix 201 22 present present JJ cord-007788-09t52zix 201 23 but but CC cord-007788-09t52zix 201 24 also also RB cord-007788-09t52zix 201 25 after after IN cord-007788-09t52zix 201 26 discharge discharge NN cord-007788-09t52zix 201 27 , , , cord-007788-09t52zix 201 28 in in IN cord-007788-09t52zix 201 29 the the DT cord-007788-09t52zix 201 30 outpatient outpatient NN cord-007788-09t52zix 201 31 setting setting NN cord-007788-09t52zix 201 32 , , , cord-007788-09t52zix 201 33 since since IN cord-007788-09t52zix 201 34 some some DT cord-007788-09t52zix 201 35 symptoms symptom NNS cord-007788-09t52zix 201 36 are be VBP cord-007788-09t52zix 201 37 rather rather RB cord-007788-09t52zix 201 38 unspecific unspecific JJ cord-007788-09t52zix 201 39 . . . cord-007788-09t52zix 202 1 Other other JJ cord-007788-09t52zix 202 2 than than IN cord-007788-09t52zix 202 3 fever fever NN cord-007788-09t52zix 202 4 , , , cord-007788-09t52zix 202 5 chills chill NNS cord-007788-09t52zix 202 6 or or CC cord-007788-09t52zix 202 7 rigouring rigouring NN cord-007788-09t52zix 202 8 , , , cord-007788-09t52zix 202 9 feeling feel VBG cord-007788-09t52zix 202 10 unwell unwell JJ cord-007788-09t52zix 202 11 or or CC cord-007788-09t52zix 202 12 different different JJ cord-007788-09t52zix 202 13 ( ( -LRB- cord-007788-09t52zix 202 14 without without IN cord-007788-09t52zix 202 15 clear clear JJ cord-007788-09t52zix 202 16 explanation explanation NN cord-007788-09t52zix 202 17 ) ) -RRB- cord-007788-09t52zix 202 18 , , , cord-007788-09t52zix 202 19 changes change NNS cord-007788-09t52zix 202 20 in in IN cord-007788-09t52zix 202 21 behaviour behaviour NN cord-007788-09t52zix 202 22 or or CC cord-007788-09t52zix 202 23 mental mental JJ cord-007788-09t52zix 202 24 changes change NNS cord-007788-09t52zix 202 25 , , , cord-007788-09t52zix 202 26 feeling feel VBG cord-007788-09t52zix 202 27 faint faint JJ cord-007788-09t52zix 202 28 or or CC cord-007788-09t52zix 202 29 changes change NNS cord-007788-09t52zix 202 30 in in IN cord-007788-09t52zix 202 31 skin skin NN cord-007788-09t52zix 202 32 tone tone NN cord-007788-09t52zix 202 33 can can MD cord-007788-09t52zix 202 34 indicate indicate VB cord-007788-09t52zix 202 35 sepsis sepsis NN cord-007788-09t52zix 202 36 . . . cord-007788-09t52zix 203 1 An an DT cord-007788-09t52zix 203 2 increased increase VBN cord-007788-09t52zix 203 3 respiratory respiratory JJ cord-007788-09t52zix 203 4 rate rate NN cord-007788-09t52zix 203 5 can can MD cord-007788-09t52zix 203 6 be be VB cord-007788-09t52zix 203 7 seen see VBN cord-007788-09t52zix 203 8 even even RB cord-007788-09t52zix 203 9 if if IN cord-007788-09t52zix 203 10 saturation saturation NN cord-007788-09t52zix 203 11 is be VBZ cord-007788-09t52zix 203 12 normal normal JJ cord-007788-09t52zix 203 13 . . . cord-007788-09t52zix 204 1 An an DT cord-007788-09t52zix 204 2 increased increase VBN cord-007788-09t52zix 204 3 pulse pulse NN cord-007788-09t52zix 204 4 and and CC cord-007788-09t52zix 204 5 lowered lower VBD cord-007788-09t52zix 204 6 blood blood NN cord-007788-09t52zix 204 7 pressure pressure NN cord-007788-09t52zix 204 8 may may MD cord-007788-09t52zix 204 9 be be VB cord-007788-09t52zix 204 10 noted note VBN cord-007788-09t52zix 204 11 . . . cord-007788-09t52zix 205 1 Some some DT cord-007788-09t52zix 205 2 patients patient NNS cord-007788-09t52zix 205 3 may may MD cord-007788-09t52zix 205 4 not not RB cord-007788-09t52zix 205 5 develop develop VB cord-007788-09t52zix 205 6 fever fever NN cord-007788-09t52zix 205 7 , , , cord-007788-09t52zix 205 8 and and CC cord-007788-09t52zix 205 9 hypothermia hypothermia NN cord-007788-09t52zix 205 10 , , , cord-007788-09t52zix 205 11 i.e. i.e. FW cord-007788-09t52zix 205 12 < < XX cord-007788-09t52zix 205 13 36 36 CD cord-007788-09t52zix 205 14 ° ° NN cord-007788-09t52zix 205 15 C c NN cord-007788-09t52zix 205 16 , , , cord-007788-09t52zix 205 17 can can MD cord-007788-09t52zix 205 18 also also RB cord-007788-09t52zix 205 19 be be VB cord-007788-09t52zix 205 20 a a DT cord-007788-09t52zix 205 21 sign sign NN cord-007788-09t52zix 205 22 of of IN cord-007788-09t52zix 205 23 sepsis sepsis NN cord-007788-09t52zix 205 24 . . . cord-007788-09t52zix 206 1 If if IN cord-007788-09t52zix 206 2 an an DT cord-007788-09t52zix 206 3 outpatient outpatient NN cord-007788-09t52zix 206 4 with with IN cord-007788-09t52zix 206 5 symptoms symptom NNS cord-007788-09t52zix 206 6 that that WDT cord-007788-09t52zix 206 7 could could MD cord-007788-09t52zix 206 8 be be VB cord-007788-09t52zix 206 9 sepsisrelated sepsisrelate VBN cord-007788-09t52zix 206 10 reports report VBZ cord-007788-09t52zix 206 11 a a DT cord-007788-09t52zix 206 12 normal normal JJ cord-007788-09t52zix 206 13 body body NN cord-007788-09t52zix 206 14 temperature temperature NN cord-007788-09t52zix 206 15 , , , cord-007788-09t52zix 206 16 it -PRON- PRP cord-007788-09t52zix 206 17 should should MD cord-007788-09t52zix 206 18 be be VB cord-007788-09t52zix 206 19 checked check VBN cord-007788-09t52zix 206 20 again again RB cord-007788-09t52zix 206 21 in in IN cord-007788-09t52zix 206 22 the the DT cord-007788-09t52zix 206 23 clinic clinic NN cord-007788-09t52zix 206 24 with with IN cord-007788-09t52zix 206 25 a a DT cord-007788-09t52zix 206 26 reliable reliable JJ cord-007788-09t52zix 206 27 thermometer thermometer NN cord-007788-09t52zix 206 28 and and CC cord-007788-09t52zix 206 29 correct correct JJ cord-007788-09t52zix 206 30 method method NN cord-007788-09t52zix 206 31 . . . cord-007788-09t52zix 207 1 Diarrhoea diarrhoea NN cord-007788-09t52zix 207 2 and and CC cord-007788-09t52zix 207 3 vomiting vomiting NN cord-007788-09t52zix 207 4 are be VBP cord-007788-09t52zix 207 5 frequently frequently RB cord-007788-09t52zix 207 6 seen see VBN cord-007788-09t52zix 207 7 in in IN cord-007788-09t52zix 207 8 sepsis sepsis NN cord-007788-09t52zix 207 9 but but CC cord-007788-09t52zix 207 10 can can MD cord-007788-09t52zix 207 11 easily easily RB cord-007788-09t52zix 207 12 be be VB cord-007788-09t52zix 207 13 mistaken mistake VBN cord-007788-09t52zix 207 14 for for IN cord-007788-09t52zix 207 15 gastroenteritis gastroenteritis NN cord-007788-09t52zix 207 16 , , , cord-007788-09t52zix 207 17 mucositis mucositis NN cord-007788-09t52zix 207 18 or or CC cord-007788-09t52zix 207 19 acute acute JJ cord-007788-09t52zix 207 20 graft graft NN cord-007788-09t52zix 207 21 versus versus IN cord-007788-09t52zix 207 22 host host NN cord-007788-09t52zix 207 23 disease disease NN cord-007788-09t52zix 207 24 ( ( -LRB- cord-007788-09t52zix 207 25 aGvHD agvhd NN cord-007788-09t52zix 207 26 ) ) -RRB- cord-007788-09t52zix 207 27 . . . cord-007788-09t52zix 208 1 Diffuse diffuse JJ cord-007788-09t52zix 208 2 or or CC cord-007788-09t52zix 208 3 local local JJ cord-007788-09t52zix 208 4 pain pain NN cord-007788-09t52zix 208 5 , , , cord-007788-09t52zix 208 6 e.g. e.g. RB cord-007788-09t52zix 208 7 in in IN cord-007788-09t52zix 208 8 the the DT cord-007788-09t52zix 208 9 abdomen abdomen NN cord-007788-09t52zix 208 10 , , , cord-007788-09t52zix 208 11 is be VBZ cord-007788-09t52zix 208 12 common common JJ cord-007788-09t52zix 208 13 . . . cord-007788-09t52zix 209 1 Falls fall NNS cord-007788-09t52zix 209 2 are be VBP cord-007788-09t52zix 209 3 often often RB cord-007788-09t52zix 209 4 secondary secondary JJ cord-007788-09t52zix 209 5 to to IN cord-007788-09t52zix 209 6 sepsis sepsis NN cord-007788-09t52zix 209 7 particularly particularly RB cord-007788-09t52zix 209 8 in in IN cord-007788-09t52zix 209 9 elderly elderly JJ cord-007788-09t52zix 209 10 patients patient NNS cord-007788-09t52zix 209 11 . . . cord-007788-09t52zix 210 1 Any any DT cord-007788-09t52zix 210 2 of of IN cord-007788-09t52zix 210 3 these these DT cord-007788-09t52zix 210 4 indices index NNS cord-007788-09t52zix 210 5 need need VBP cord-007788-09t52zix 210 6 prompt prompt JJ cord-007788-09t52zix 210 7 and and CC cord-007788-09t52zix 210 8 thorough thorough JJ cord-007788-09t52zix 210 9 assessment assessment NN cord-007788-09t52zix 210 10 . . . cord-007788-09t52zix 211 1 The the DT cord-007788-09t52zix 211 2 concept concept NN cord-007788-09t52zix 211 3 of of IN cord-007788-09t52zix 211 4 the the DT cord-007788-09t52zix 211 5 Sepsis Sepsis NNP cord-007788-09t52zix 211 6 Six Six NNP cord-007788-09t52zix 211 7 has have VBZ cord-007788-09t52zix 211 8 been be VBN cord-007788-09t52zix 211 9 developed develop VBN cord-007788-09t52zix 211 10 as as IN cord-007788-09t52zix 211 11 a a DT cord-007788-09t52zix 211 12 guide guide NN cord-007788-09t52zix 211 13 to to TO cord-007788-09t52zix 211 14 prioritise prioritise VB cord-007788-09t52zix 211 15 interventions intervention NNS cord-007788-09t52zix 211 16 in in IN cord-007788-09t52zix 211 17 patients patient NNS cord-007788-09t52zix 211 18 where where WRB cord-007788-09t52zix 211 19 sepsis sepsis NN cord-007788-09t52zix 211 20 is be VBZ cord-007788-09t52zix 211 21 suspected suspect VBN cord-007788-09t52zix 211 22 ( ( -LRB- cord-007788-09t52zix 211 23 Daniels Daniels NNP cord-007788-09t52zix 211 24 et et NNP cord-007788-09t52zix 211 25 al al NNP cord-007788-09t52zix 211 26 . . . cord-007788-09t52zix 211 27 2011 2011 CD cord-007788-09t52zix 212 1 When when WRB cord-007788-09t52zix 212 2 sepsis sepsis NN cord-007788-09t52zix 212 3 is be VBZ cord-007788-09t52zix 212 4 suspected suspect VBN cord-007788-09t52zix 212 5 , , , cord-007788-09t52zix 212 6 all all DT cord-007788-09t52zix 212 7 cultures culture NNS cord-007788-09t52zix 212 8 should should MD cord-007788-09t52zix 212 9 be be VB cord-007788-09t52zix 212 10 taken take VBN cord-007788-09t52zix 212 11 prior prior RB cord-007788-09t52zix 212 12 to to IN cord-007788-09t52zix 212 13 commencing commence VBG cord-007788-09t52zix 212 14 antimicrobials antimicrobial NNS cord-007788-09t52zix 212 15 , , , cord-007788-09t52zix 212 16 if if IN cord-007788-09t52zix 212 17 possible possible JJ cord-007788-09t52zix 213 1 ( ( -LRB- cord-007788-09t52zix 213 2 Rhodes Rhodes NNP cord-007788-09t52zix 213 3 et et NNP cord-007788-09t52zix 213 4 al al NNP cord-007788-09t52zix 213 5 . . . cord-007788-09t52zix 213 6 2017 2017 CD cord-007788-09t52zix 213 7 ) ) -RRB- cord-007788-09t52zix 213 8 . . . cord-007788-09t52zix 214 1 Cultures culture NNS cord-007788-09t52zix 214 2 should should MD cord-007788-09t52zix 214 3 be be VB cord-007788-09t52zix 214 4 taken take VBN cord-007788-09t52zix 214 5 from from IN cord-007788-09t52zix 214 6 central central JJ cord-007788-09t52zix 214 7 lines line NNS cord-007788-09t52zix 214 8 , , , cord-007788-09t52zix 214 9 wounds wound NNS cord-007788-09t52zix 214 10 , , , cord-007788-09t52zix 214 11 nasopharynx nasopharynx NN cord-007788-09t52zix 214 12 , , , cord-007788-09t52zix 214 13 urine urine NN cord-007788-09t52zix 214 14 and and CC cord-007788-09t52zix 214 15 faeces faece NNS cord-007788-09t52zix 214 16 . . . cord-007788-09t52zix 215 1 It -PRON- PRP cord-007788-09t52zix 215 2 is be VBZ cord-007788-09t52zix 215 3 also also RB cord-007788-09t52zix 215 4 sensible sensible JJ cord-007788-09t52zix 215 5 to to TO cord-007788-09t52zix 215 6 consider consider VB cord-007788-09t52zix 215 7 peripheral peripheral JJ cord-007788-09t52zix 215 8 i.v i.v NNP cord-007788-09t52zix 215 9 . . NNP cord-007788-09t52zix 215 10 cannulae cannulae NNP cord-007788-09t52zix 215 11 as as IN cord-007788-09t52zix 215 12 a a DT cord-007788-09t52zix 215 13 possible possible JJ cord-007788-09t52zix 215 14 source source NN cord-007788-09t52zix 215 15 of of IN cord-007788-09t52zix 215 16 infection infection NN cord-007788-09t52zix 215 17 . . . cord-007788-09t52zix 216 1 Despite despite IN cord-007788-09t52zix 216 2 conventional conventional JJ cord-007788-09t52zix 216 3 practice practice NN cord-007788-09t52zix 216 4 to to TO cord-007788-09t52zix 216 5 collect collect VB cord-007788-09t52zix 216 6 blood blood NN cord-007788-09t52zix 216 7 cultures culture NNS cord-007788-09t52zix 216 8 at at IN cord-007788-09t52zix 216 9 a a DT cord-007788-09t52zix 216 10 fever fever NN cord-007788-09t52zix 216 11 spike spike NN cord-007788-09t52zix 216 12 in in IN cord-007788-09t52zix 216 13 order order NN cord-007788-09t52zix 216 14 to to TO cord-007788-09t52zix 216 15 increase increase VB cord-007788-09t52zix 216 16 the the DT cord-007788-09t52zix 216 17 chances chance NNS cord-007788-09t52zix 216 18 of of IN cord-007788-09t52zix 216 19 detecting detect VBG cord-007788-09t52zix 216 20 bacteraemia bacteraemia NN cord-007788-09t52zix 216 21 , , , cord-007788-09t52zix 216 22 there there EX cord-007788-09t52zix 216 23 is be VBZ cord-007788-09t52zix 216 24 so so RB cord-007788-09t52zix 216 25 far far RB cord-007788-09t52zix 216 26 no no DT cord-007788-09t52zix 216 27 data datum NNS cord-007788-09t52zix 216 28 to to TO cord-007788-09t52zix 216 29 support support VB cord-007788-09t52zix 216 30 this this DT cord-007788-09t52zix 216 31 principle principle NN cord-007788-09t52zix 217 1 ( ( -LRB- cord-007788-09t52zix 217 2 Kee Kee NNP cord-007788-09t52zix 217 3 et et NNP cord-007788-09t52zix 217 4 al al NNP cord-007788-09t52zix 217 5 . . . cord-007788-09t52zix 217 6 2016 2016 CD cord-007788-09t52zix 217 7 ) ) -RRB- cord-007788-09t52zix 217 8 . . . cord-007788-09t52zix 218 1 Testing testing NN cord-007788-09t52zix 218 2 could could MD cord-007788-09t52zix 218 3 include include VB cord-007788-09t52zix 218 4 polymerase polymerase NN cord-007788-09t52zix 218 5 chain chain NN cord-007788-09t52zix 218 6 reaction reaction NN cord-007788-09t52zix 218 7 ( ( -LRB- cord-007788-09t52zix 218 8 PCR PCR NNP cord-007788-09t52zix 218 9 ) ) -RRB- cord-007788-09t52zix 218 10 virology virology NN cord-007788-09t52zix 218 11 ( ( -LRB- cord-007788-09t52zix 218 12 e.g. e.g. RB cord-007788-09t52zix 218 13 for for IN cord-007788-09t52zix 218 14 cytomegalovirus cytomegalovirus NNP cord-007788-09t52zix 218 15 ( ( -LRB- cord-007788-09t52zix 218 16 CMV CMV NNP cord-007788-09t52zix 218 17 ) ) -RRB- cord-007788-09t52zix 218 18 or or CC cord-007788-09t52zix 218 19 Epstein Epstein NNP cord-007788-09t52zix 218 20 - - HYPH cord-007788-09t52zix 218 21 Barr Barr NNP cord-007788-09t52zix 218 22 virus virus NN cord-007788-09t52zix 218 23 ( ( -LRB- cord-007788-09t52zix 218 24 EBV EBV NNP cord-007788-09t52zix 218 25 ) ) -RRB- cord-007788-09t52zix 218 26 ) ) -RRB- cord-007788-09t52zix 218 27 and and CC cord-007788-09t52zix 218 28 screening screen VBG cord-007788-09t52zix 218 29 for for IN cord-007788-09t52zix 218 30 fungus fungus NN cord-007788-09t52zix 218 31 ( ( -LRB- cord-007788-09t52zix 218 32 e.g. e.g. DT cord-007788-09t52zix 218 33 oral oral JJ cord-007788-09t52zix 218 34 swab swab NN cord-007788-09t52zix 218 35 ) ) -RRB- cord-007788-09t52zix 218 36 , , , cord-007788-09t52zix 218 37 depending depend VBG cord-007788-09t52zix 218 38 on on IN cord-007788-09t52zix 218 39 symptoms symptom NNS cord-007788-09t52zix 218 40 and and CC cord-007788-09t52zix 218 41 suspected suspect VBN cord-007788-09t52zix 218 42 microbial microbial JJ cord-007788-09t52zix 218 43 agent agent NN cord-007788-09t52zix 218 44 . . . cord-007788-09t52zix 219 1 For for IN cord-007788-09t52zix 219 2 the the DT cord-007788-09t52zix 219 3 procedures procedure NNS cord-007788-09t52zix 219 4 for for IN cord-007788-09t52zix 219 5 diagnosis diagnosis NN cord-007788-09t52zix 219 6 of of IN cord-007788-09t52zix 219 7 central central JJ cord-007788-09t52zix 219 8 line line NN cord-007788-09t52zix 219 9 - - HYPH cord-007788-09t52zix 219 10 associated associate VBN cord-007788-09t52zix 219 11 bloodstream bloodstream NN cord-007788-09t52zix 219 12 infections infection NNS cord-007788-09t52zix 219 13 ( ( -LRB- cord-007788-09t52zix 219 14 CLABSI CLABSI NNP cord-007788-09t52zix 219 15 ) ) -RRB- cord-007788-09t52zix 219 16 , , , cord-007788-09t52zix 219 17 please please UH cord-007788-09t52zix 219 18 see see VB cord-007788-09t52zix 219 19 Chap Chap NNP cord-007788-09t52zix 219 20 . . . cord-007788-09t52zix 220 1 4 4 LS cord-007788-09t52zix 220 2 . . . cord-007788-09t52zix 221 1 Laboratory laboratory NN cord-007788-09t52zix 221 2 tests test NNS cord-007788-09t52zix 221 3 should should MD cord-007788-09t52zix 221 4 be be VB cord-007788-09t52zix 221 5 taken take VBN cord-007788-09t52zix 221 6 to to TO cord-007788-09t52zix 221 7 monitor monitor VB cord-007788-09t52zix 221 8 electrolyte electrolyte JJ cord-007788-09t52zix 221 9 status status NN cord-007788-09t52zix 221 10 , , , cord-007788-09t52zix 221 11 organ organ NN cord-007788-09t52zix 221 12 function function NN cord-007788-09t52zix 221 13 , , , cord-007788-09t52zix 221 14 blood blood NN cord-007788-09t52zix 221 15 count count NN cord-007788-09t52zix 221 16 and and CC cord-007788-09t52zix 221 17 signs sign NNS cord-007788-09t52zix 221 18 of of IN cord-007788-09t52zix 221 19 infection infection NN cord-007788-09t52zix 221 20 . . . cord-007788-09t52zix 222 1 A a DT cord-007788-09t52zix 222 2 site site NN cord-007788-09t52zix 222 3 of of IN cord-007788-09t52zix 222 4 infection infection NN cord-007788-09t52zix 222 5 may may MD cord-007788-09t52zix 222 6 not not RB cord-007788-09t52zix 222 7 always always RB cord-007788-09t52zix 222 8 be be VB cord-007788-09t52zix 222 9 identified identify VBN cord-007788-09t52zix 222 10 . . . cord-007788-09t52zix 223 1 If if IN cord-007788-09t52zix 223 2 a a DT cord-007788-09t52zix 223 3 source source NN cord-007788-09t52zix 223 4 of of IN cord-007788-09t52zix 223 5 infection infection NN cord-007788-09t52zix 223 6 is be VBZ cord-007788-09t52zix 223 7 confirmed confirm VBN cord-007788-09t52zix 223 8 , , , cord-007788-09t52zix 223 9 or or CC cord-007788-09t52zix 223 10 strongly strongly RB cord-007788-09t52zix 223 11 suspected suspect VBN cord-007788-09t52zix 223 12 , , , cord-007788-09t52zix 223 13 applicable applicable JJ cord-007788-09t52zix 223 14 actions action NNS cord-007788-09t52zix 223 15 should should MD cord-007788-09t52zix 223 16 be be VB cord-007788-09t52zix 223 17 taken take VBN cord-007788-09t52zix 223 18 , , , cord-007788-09t52zix 223 19 e.g. e.g. RB cord-007788-09t52zix 223 20 wound wind VBN cord-007788-09t52zix 223 21 care care NN cord-007788-09t52zix 223 22 or or CC cord-007788-09t52zix 223 23 removal removal NN cord-007788-09t52zix 223 24 of of IN cord-007788-09t52zix 223 25 peripheral peripheral JJ cord-007788-09t52zix 223 26 i.v i.v NNP cord-007788-09t52zix 223 27 . . . cord-007788-09t52zix 223 28 needle needle NN cord-007788-09t52zix 223 29 with with IN cord-007788-09t52zix 223 30 signs sign NNS cord-007788-09t52zix 223 31 of of IN cord-007788-09t52zix 223 32 thrombophlebitis thrombophlebitis NNP cord-007788-09t52zix 223 33 ( ( -LRB- cord-007788-09t52zix 223 34 Schorr Schorr NNP cord-007788-09t52zix 223 35 et et NNP cord-007788-09t52zix 223 36 al al NNP cord-007788-09t52zix 223 37 . . NNP cord-007788-09t52zix 223 38 2014 2014 CD cord-007788-09t52zix 223 39 ) ) -RRB- cord-007788-09t52zix 223 40 . . . cord-007788-09t52zix 224 1 Upon upon IN cord-007788-09t52zix 224 2 initiation initiation NN cord-007788-09t52zix 224 3 of of IN cord-007788-09t52zix 224 4 antimicrobial antimicrobial JJ cord-007788-09t52zix 224 5 treatment treatment NN cord-007788-09t52zix 224 6 , , , cord-007788-09t52zix 224 7 a a DT cord-007788-09t52zix 224 8 broad broad JJ cord-007788-09t52zix 224 9 - - HYPH cord-007788-09t52zix 224 10 spectrum spectrum NN cord-007788-09t52zix 224 11 antibiotic antibiotic NN cord-007788-09t52zix 224 12 is be VBZ cord-007788-09t52zix 224 13 usually usually RB cord-007788-09t52zix 224 14 used use VBN cord-007788-09t52zix 224 15 . . . cord-007788-09t52zix 225 1 Depending depend VBG cord-007788-09t52zix 225 2 on on IN cord-007788-09t52zix 225 3 the the DT cord-007788-09t52zix 225 4 results result NNS cord-007788-09t52zix 225 5 of of IN cord-007788-09t52zix 225 6 the the DT cord-007788-09t52zix 225 7 cultures culture NNS cord-007788-09t52zix 225 8 performed perform VBN cord-007788-09t52zix 225 9 , , , cord-007788-09t52zix 225 10 the the DT cord-007788-09t52zix 225 11 chosen choose VBN cord-007788-09t52zix 225 12 drug drug NN cord-007788-09t52zix 225 13 may may MD cord-007788-09t52zix 225 14 need need VB cord-007788-09t52zix 225 15 to to TO cord-007788-09t52zix 225 16 be be VB cord-007788-09t52zix 225 17 changed change VBN cord-007788-09t52zix 225 18 later later RB cord-007788-09t52zix 225 19 . . . cord-007788-09t52zix 226 1 Fever fever NN cord-007788-09t52zix 226 2 and and CC cord-007788-09t52zix 226 3 infection infection NN cord-007788-09t52zix 226 4 will will MD cord-007788-09t52zix 226 5 affect affect VB cord-007788-09t52zix 226 6 the the DT cord-007788-09t52zix 226 7 blood blood NN cord-007788-09t52zix 226 8 count count NN cord-007788-09t52zix 226 9 and and CC cord-007788-09t52zix 226 10 frequently frequently RB cord-007788-09t52zix 226 11 cause cause VB cord-007788-09t52zix 226 12 platelet platelet NN cord-007788-09t52zix 226 13 consumption consumption NN cord-007788-09t52zix 226 14 why why WRB cord-007788-09t52zix 226 15 transfusions transfusion NNS cord-007788-09t52zix 226 16 may may MD cord-007788-09t52zix 226 17 be be VB cord-007788-09t52zix 226 18 necessary necessary JJ cord-007788-09t52zix 226 19 . . . cord-007788-09t52zix 227 1 Early early JJ cord-007788-09t52zix 227 2 recognition recognition NN cord-007788-09t52zix 227 3 and and CC cord-007788-09t52zix 227 4 intervention intervention NN cord-007788-09t52zix 227 5 are be VBP cord-007788-09t52zix 227 6 achieved achieve VBN cord-007788-09t52zix 227 7 by by IN cord-007788-09t52zix 227 8 frequent frequent JJ cord-007788-09t52zix 227 9 monitoring monitoring NN cord-007788-09t52zix 227 10 of of IN cord-007788-09t52zix 227 11 the the DT cord-007788-09t52zix 227 12 patient patient NN cord-007788-09t52zix 227 13 's 's POS cord-007788-09t52zix 227 14 vital vital JJ cord-007788-09t52zix 227 15 signs sign NNS cord-007788-09t52zix 227 16 and and CC cord-007788-09t52zix 227 17 general general JJ cord-007788-09t52zix 227 18 condition condition NN cord-007788-09t52zix 227 19 and and CC cord-007788-09t52zix 227 20 paying pay VBG cord-007788-09t52zix 227 21 attention attention NN cord-007788-09t52zix 227 22 to to IN cord-007788-09t52zix 227 23 subtle subtle JJ cord-007788-09t52zix 227 24 changes change NNS cord-007788-09t52zix 227 25 that that WDT cord-007788-09t52zix 227 26 should should MD cord-007788-09t52zix 227 27 be be VB cord-007788-09t52zix 227 28 promptly promptly RB cord-007788-09t52zix 227 29 reported report VBN cord-007788-09t52zix 227 30 . . . cord-007788-09t52zix 228 1 As as IN cord-007788-09t52zix 228 2 described describe VBN cord-007788-09t52zix 228 3 above above RB cord-007788-09t52zix 228 4 , , , cord-007788-09t52zix 228 5 immediate immediate JJ cord-007788-09t52zix 228 6 action action NN cord-007788-09t52zix 228 7 is be VBZ cord-007788-09t52zix 228 8 required require VBN cord-007788-09t52zix 228 9 at at IN cord-007788-09t52zix 228 10 the the DT cord-007788-09t52zix 228 11 first first JJ cord-007788-09t52zix 228 12 indication indication NN cord-007788-09t52zix 228 13 of of IN cord-007788-09t52zix 228 14 sepsis sepsis NN cord-007788-09t52zix 228 15 . . . cord-007788-09t52zix 229 1 When when WRB cord-007788-09t52zix 229 2 treatment treatment NN cord-007788-09t52zix 229 3 has have VBZ cord-007788-09t52zix 229 4 been be VBN cord-007788-09t52zix 229 5 initiated initiate VBN cord-007788-09t52zix 229 6 , , , cord-007788-09t52zix 229 7 the the DT cord-007788-09t52zix 229 8 patient patient NN cord-007788-09t52zix 229 9 must must MD cord-007788-09t52zix 229 10 be be VB cord-007788-09t52zix 229 11 continually continually RB cord-007788-09t52zix 229 12 monitored monitor VBN cord-007788-09t52zix 229 13 to to TO cord-007788-09t52zix 229 14 determine determine VB cord-007788-09t52zix 229 15 the the DT cord-007788-09t52zix 229 16 effect effect NN cord-007788-09t52zix 229 17 of of IN cord-007788-09t52zix 229 18 treatment treatment NN cord-007788-09t52zix 229 19 or or CC cord-007788-09t52zix 229 20 worsening worsening NN cord-007788-09t52zix 229 21 of of IN cord-007788-09t52zix 229 22 the the DT cord-007788-09t52zix 229 23 condition condition NN cord-007788-09t52zix 229 24 . . . cord-007788-09t52zix 230 1 This this DT cord-007788-09t52zix 230 2 includes include VBZ cord-007788-09t52zix 230 3 vital vital JJ cord-007788-09t52zix 230 4 signs sign NNS cord-007788-09t52zix 230 5 , , , cord-007788-09t52zix 230 6 fluid fluid JJ cord-007788-09t52zix 230 7 balance balance NN cord-007788-09t52zix 230 8 including include VBG cord-007788-09t52zix 230 9 weight weight NN cord-007788-09t52zix 230 10 and and CC cord-007788-09t52zix 230 11 assessment assessment NN cord-007788-09t52zix 230 12 of of IN cord-007788-09t52zix 230 13 identified identify VBN cord-007788-09t52zix 230 14 and/or and/or CC cord-007788-09t52zix 230 15 potential potential JJ cord-007788-09t52zix 230 16 infection infection NN cord-007788-09t52zix 230 17 sites site NNS cord-007788-09t52zix 230 18 ( ( -LRB- cord-007788-09t52zix 230 19 mouth mouth NN cord-007788-09t52zix 230 20 , , , cord-007788-09t52zix 230 21 skin skin NN cord-007788-09t52zix 230 22 , , , cord-007788-09t52zix 230 23 any any DT cord-007788-09t52zix 230 24 indwelling indwell VBG cord-007788-09t52zix 230 25 or or CC cord-007788-09t52zix 230 26 tunnelled tunnelled JJ cord-007788-09t52zix 230 27 catheter catheter NN cord-007788-09t52zix 230 28 , , , cord-007788-09t52zix 230 29 urine urine NN cord-007788-09t52zix 230 30 , , , cord-007788-09t52zix 230 31 stools stool NNS cord-007788-09t52zix 230 32 , , , cord-007788-09t52zix 230 33 etc etc FW cord-007788-09t52zix 230 34 . . . cord-007788-09t52zix 230 35 ) ) -RRB- cord-007788-09t52zix 230 36 , , , cord-007788-09t52zix 230 37 mental mental JJ cord-007788-09t52zix 230 38 status status NN cord-007788-09t52zix 230 39 , , , cord-007788-09t52zix 230 40 signs sign NNS cord-007788-09t52zix 230 41 of of IN cord-007788-09t52zix 230 42 bleeding bleed VBG cord-007788-09t52zix 230 43 , , , cord-007788-09t52zix 230 44 pain pain NN cord-007788-09t52zix 230 45 and and CC cord-007788-09t52zix 230 46 general general JJ cord-007788-09t52zix 230 47 appearance appearance NN cord-007788-09t52zix 230 48 and and CC cord-007788-09t52zix 230 49 well well RB cord-007788-09t52zix 230 50 - - HYPH cord-007788-09t52zix 230 51 being being NN cord-007788-09t52zix 230 52 . . . cord-007788-09t52zix 231 1 Antibiotics antibiotic NNS cord-007788-09t52zix 231 2 should should MD cord-007788-09t52zix 231 3 be be VB cord-007788-09t52zix 231 4 delivered deliver VBN cord-007788-09t52zix 231 5 with with IN cord-007788-09t52zix 231 6 strict strict JJ cord-007788-09t52zix 231 7 adherence adherence NN cord-007788-09t52zix 231 8 to to IN cord-007788-09t52zix 231 9 the the DT cord-007788-09t52zix 231 10 prescribed prescribed JJ cord-007788-09t52zix 231 11 time time NN cord-007788-09t52zix 231 12 schedule schedule NN cord-007788-09t52zix 231 13 . . . cord-007788-09t52zix 232 1 Antipyretics antipyretic NNS cord-007788-09t52zix 232 2 should should MD cord-007788-09t52zix 232 3 be be VB cord-007788-09t52zix 232 4 avoided avoid VBN cord-007788-09t52zix 232 5 since since IN cord-007788-09t52zix 232 6 they -PRON- PRP cord-007788-09t52zix 232 7 may may MD cord-007788-09t52zix 232 8 mask mask VB cord-007788-09t52zix 232 9 fever fever NN cord-007788-09t52zix 232 10 but but CC cord-007788-09t52zix 232 11 may may MD cord-007788-09t52zix 232 12 under under IN cord-007788-09t52zix 232 13 certain certain JJ cord-007788-09t52zix 232 14 circumstances circumstance NNS cord-007788-09t52zix 232 15 be be VB cord-007788-09t52zix 232 16 used use VBN cord-007788-09t52zix 232 17 to to TO cord-007788-09t52zix 232 18 alleviate alleviate VB cord-007788-09t52zix 232 19 patient patient JJ cord-007788-09t52zix 232 20 discomfort discomfort NN cord-007788-09t52zix 232 21 and and CC cord-007788-09t52zix 232 22 pain pain NN cord-007788-09t52zix 232 23 . . . cord-007788-09t52zix 233 1 Laboratory laboratory NN cord-007788-09t52zix 233 2 tests test VBZ cord-007788-09t52zix 233 3 results result NNS cord-007788-09t52zix 233 4 will will MD cord-007788-09t52zix 233 5 guide guide VB cord-007788-09t52zix 233 6 the the DT cord-007788-09t52zix 233 7 need need NN cord-007788-09t52zix 233 8 for for IN cord-007788-09t52zix 233 9 electrolyte electrolyte JJ cord-007788-09t52zix 233 10 replacement replacement NN cord-007788-09t52zix 233 11 and and CC cord-007788-09t52zix 233 12 blood blood NN cord-007788-09t52zix 233 13 product product NN cord-007788-09t52zix 233 14 transfusion transfusion NN cord-007788-09t52zix 233 15 that that WDT cord-007788-09t52zix 233 16 may may MD cord-007788-09t52zix 233 17 be be VB cord-007788-09t52zix 233 18 ordered order VBN cord-007788-09t52zix 233 19 prophylactically prophylactically RB cord-007788-09t52zix 233 20 or or CC cord-007788-09t52zix 233 21 in in IN cord-007788-09t52zix 233 22 case case NN cord-007788-09t52zix 233 23 of of IN cord-007788-09t52zix 233 24 bleeding bleed VBG cord-007788-09t52zix 233 25 . . . cord-007788-09t52zix 234 1 Cultures culture NNS cord-007788-09t52zix 234 2 may may MD cord-007788-09t52zix 234 3 need need VB cord-007788-09t52zix 234 4 to to TO cord-007788-09t52zix 234 5 be be VB cord-007788-09t52zix 234 6 repeated repeat VBN cord-007788-09t52zix 234 7 to to TO cord-007788-09t52zix 234 8 confirm confirm VB cord-007788-09t52zix 234 9 infection infection NN cord-007788-09t52zix 234 10 and/or and/or CC cord-007788-09t52zix 234 11 response response NN cord-007788-09t52zix 234 12 to to IN cord-007788-09t52zix 234 13 treatment treatment NN cord-007788-09t52zix 234 14 . . . cord-007788-09t52zix 235 1 Oxygen oxygen NN cord-007788-09t52zix 235 2 should should MD cord-007788-09t52zix 235 3 be be VB cord-007788-09t52zix 235 4 administered administer VBN cord-007788-09t52zix 235 5 as as IN cord-007788-09t52zix 235 6 needed need VBN cord-007788-09t52zix 235 7 to to TO cord-007788-09t52zix 235 8 ensure ensure VB cord-007788-09t52zix 235 9 adequate adequate JJ cord-007788-09t52zix 235 10 saturation saturation NN cord-007788-09t52zix 235 11 ( ( -LRB- cord-007788-09t52zix 235 12 i.e. i.e. FW cord-007788-09t52zix 235 13 ≥94 ≥94 NNP cord-007788-09t52zix 235 14 % % NN cord-007788-09t52zix 235 15 , , , cord-007788-09t52zix 235 16 or or CC cord-007788-09t52zix 235 17 88 88 CD cord-007788-09t52zix 235 18 - - SYM cord-007788-09t52zix 235 19 92 92 CD cord-007788-09t52zix 235 20 % % NN cord-007788-09t52zix 235 21 for for IN cord-007788-09t52zix 235 22 patients patient NNS cord-007788-09t52zix 235 23 with with IN cord-007788-09t52zix 235 24 chronic chronic JJ cord-007788-09t52zix 235 25 obstructive obstructive JJ cord-007788-09t52zix 235 26 pulmonary pulmonary JJ cord-007788-09t52zix 235 27 disease disease NN cord-007788-09t52zix 235 28 ( ( -LRB- cord-007788-09t52zix 235 29 COPD COPD NNP cord-007788-09t52zix 235 30 ) ) -RRB- cord-007788-09t52zix 236 1 ( ( -LRB- cord-007788-09t52zix 236 2 Royal Royal NNP cord-007788-09t52zix 236 3 College College NNP cord-007788-09t52zix 236 4 of of IN cord-007788-09t52zix 236 5 Physicians Physicians NNPS cord-007788-09t52zix 236 6 2012 2012 CD cord-007788-09t52zix 236 7 ) ) -RRB- cord-007788-09t52zix 236 8 ) ) -RRB- cord-007788-09t52zix 236 9 . . . cord-007788-09t52zix 237 1 If if IN cord-007788-09t52zix 237 2 the the DT cord-007788-09t52zix 237 3 patient patient NN cord-007788-09t52zix 237 4 's 's POS cord-007788-09t52zix 237 5 condition condition NN cord-007788-09t52zix 237 6 worsens worsen VBZ cord-007788-09t52zix 237 7 and and CC cord-007788-09t52zix 237 8 organ organ NN cord-007788-09t52zix 237 9 support support NN cord-007788-09t52zix 237 10 such such JJ cord-007788-09t52zix 237 11 as as IN cord-007788-09t52zix 237 12 assisted assist VBN cord-007788-09t52zix 237 13 ventilation ventilation NN cord-007788-09t52zix 237 14 or or CC cord-007788-09t52zix 237 15 haemodialysis haemodialysis NNP cord-007788-09t52zix 237 16 is be VBZ cord-007788-09t52zix 237 17 required require VBN cord-007788-09t52zix 237 18 , , , cord-007788-09t52zix 237 19 the the DT cord-007788-09t52zix 237 20 patient patient NN cord-007788-09t52zix 237 21 may may MD cord-007788-09t52zix 237 22 need need VB cord-007788-09t52zix 237 23 to to TO cord-007788-09t52zix 237 24 be be VB cord-007788-09t52zix 237 25 prepared prepare VBN cord-007788-09t52zix 237 26 for for IN cord-007788-09t52zix 237 27 transfer transfer NN cord-007788-09t52zix 237 28 to to IN cord-007788-09t52zix 237 29 the the DT cord-007788-09t52zix 237 30 intensive intensive JJ cord-007788-09t52zix 237 31 care care NN cord-007788-09t52zix 237 32 unit unit NN cord-007788-09t52zix 237 33 ( ( -LRB- cord-007788-09t52zix 237 34 ICU ICU NNP cord-007788-09t52zix 237 35 ) ) -RRB- cord-007788-09t52zix 237 36 . . . cord-007788-09t52zix 238 1 Extra extra JJ cord-007788-09t52zix 238 2 psychological psychological JJ cord-007788-09t52zix 238 3 support support NN cord-007788-09t52zix 238 4 is be VBZ cord-007788-09t52zix 238 5 important important JJ cord-007788-09t52zix 238 6 for for IN cord-007788-09t52zix 238 7 both both CC cord-007788-09t52zix 238 8 the the DT cord-007788-09t52zix 238 9 patient patient NN cord-007788-09t52zix 238 10 and and CC cord-007788-09t52zix 238 11 family family NN cord-007788-09t52zix 238 12 . . . cord-007788-09t52zix 239 1 Educating educate VBG cord-007788-09t52zix 239 2 the the DT cord-007788-09t52zix 239 3 patient patient NN cord-007788-09t52zix 239 4 and and CC cord-007788-09t52zix 239 5 the the DT cord-007788-09t52zix 239 6 carer carer NN cord-007788-09t52zix 239 7 about about IN cord-007788-09t52zix 239 8 the the DT cord-007788-09t52zix 239 9 condition condition NN cord-007788-09t52zix 239 10 and and CC cord-007788-09t52zix 239 11 actions action NNS cord-007788-09t52zix 239 12 taken take VBN cord-007788-09t52zix 239 13 or or CC cord-007788-09t52zix 239 14 planned plan VBN cord-007788-09t52zix 239 15 will will MD cord-007788-09t52zix 239 16 prevent prevent VB cord-007788-09t52zix 239 17 unnecessary unnecessary JJ cord-007788-09t52zix 239 18 worrying worrying NN cord-007788-09t52zix 239 19 and and CC cord-007788-09t52zix 239 20 enable enable VB cord-007788-09t52zix 239 21 them -PRON- PRP cord-007788-09t52zix 239 22 to to TO cord-007788-09t52zix 239 23 alert alert VB cord-007788-09t52zix 239 24 the the DT cord-007788-09t52zix 239 25 staff staff NN cord-007788-09t52zix 239 26 about about IN cord-007788-09t52zix 239 27 symptoms symptom NNS cord-007788-09t52zix 239 28 or or CC cord-007788-09t52zix 239 29 changes change NNS cord-007788-09t52zix 239 30 . . . cord-007788-09t52zix 240 1 Information information NN cord-007788-09t52zix 240 2 and and CC cord-007788-09t52zix 240 3 education education NN cord-007788-09t52zix 240 4 may may MD cord-007788-09t52zix 240 5 also also RB cord-007788-09t52zix 240 6 facilitate facilitate VB cord-007788-09t52zix 240 7 mental mental JJ cord-007788-09t52zix 240 8 preparedness preparedness NN cord-007788-09t52zix 240 9 if if IN cord-007788-09t52zix 240 10 the the DT cord-007788-09t52zix 240 11 condition condition NN cord-007788-09t52zix 240 12 worsens worsen VBZ cord-007788-09t52zix 240 13 and and CC cord-007788-09t52zix 240 14 a a DT cord-007788-09t52zix 240 15 higher high JJR cord-007788-09t52zix 240 16 level level NN cord-007788-09t52zix 240 17 of of IN cord-007788-09t52zix 240 18 care care NN cord-007788-09t52zix 240 19 , , , cord-007788-09t52zix 240 20 ICU ICU NNP cord-007788-09t52zix 240 21 , , , cord-007788-09t52zix 240 22 is be VBZ cord-007788-09t52zix 240 23 needed need VBN cord-007788-09t52zix 240 24 . . . cord-007788-09t52zix 241 1 Patients patient NNS cord-007788-09t52zix 241 2 with with IN cord-007788-09t52zix 241 3 sepsis sepsis NN cord-007788-09t52zix 241 4 are be VBP cord-007788-09t52zix 241 5 likely likely JJ cord-007788-09t52zix 241 6 to to TO cord-007788-09t52zix 241 7 need need VB cord-007788-09t52zix 241 8 additional additional JJ cord-007788-09t52zix 241 9 nursing nursing NN cord-007788-09t52zix 241 10 care care NN cord-007788-09t52zix 241 11 such such JJ cord-007788-09t52zix 241 12 as as IN cord-007788-09t52zix 241 13 assistance assistance NN cord-007788-09t52zix 241 14 with with IN cord-007788-09t52zix 241 15 oral oral JJ cord-007788-09t52zix 241 16 care care NN cord-007788-09t52zix 241 17 and and CC cord-007788-09t52zix 241 18 personal personal JJ cord-007788-09t52zix 241 19 hygiene hygiene NN cord-007788-09t52zix 241 20 . . . cord-007788-09t52zix 242 1 It -PRON- PRP cord-007788-09t52zix 242 2 is be VBZ cord-007788-09t52zix 242 3 important important JJ cord-007788-09t52zix 242 4 to to TO cord-007788-09t52zix 242 5 ensure ensure VB cord-007788-09t52zix 242 6 that that IN cord-007788-09t52zix 242 7 the the DT cord-007788-09t52zix 242 8 patient patient NN cord-007788-09t52zix 242 9 's 's POS cord-007788-09t52zix 242 10 and and CC cord-007788-09t52zix 242 11 caregivers caregiver NNS cord-007788-09t52zix 242 12 ' ' POS cord-007788-09t52zix 242 13 information information NN cord-007788-09t52zix 242 14 , , , cord-007788-09t52zix 242 15 education education NN cord-007788-09t52zix 242 16 and and CC cord-007788-09t52zix 242 17 support support NN cord-007788-09t52zix 242 18 needs need NNS cord-007788-09t52zix 242 19 are be VBP cord-007788-09t52zix 242 20 met meet VBN cord-007788-09t52zix 242 21 . . . cord-007788-09t52zix 243 1 On on IN cord-007788-09t52zix 243 2 discharge discharge NN cord-007788-09t52zix 243 3 from from IN cord-007788-09t52zix 243 4 the the DT cord-007788-09t52zix 243 5 hospital hospital NN cord-007788-09t52zix 243 6 , , , cord-007788-09t52zix 243 7 we -PRON- PRP cord-007788-09t52zix 243 8 need need VBP cord-007788-09t52zix 243 9 to to TO cord-007788-09t52zix 243 10 ensure ensure VB cord-007788-09t52zix 243 11 that that IN cord-007788-09t52zix 243 12 the the DT cord-007788-09t52zix 243 13 patient patient NN cord-007788-09t52zix 243 14 and and CC cord-007788-09t52zix 243 15 their -PRON- PRP$ cord-007788-09t52zix 243 16 caregiver caregiver NN cord-007788-09t52zix 243 17 are be VBP cord-007788-09t52zix 243 18 aware aware JJ cord-007788-09t52zix 243 19 of of IN cord-007788-09t52zix 243 20 when when WRB cord-007788-09t52zix 243 21 , , , cord-007788-09t52zix 243 22 why why WRB cord-007788-09t52zix 243 23 and and CC cord-007788-09t52zix 243 24 how how WRB cord-007788-09t52zix 243 25 to to TO cord-007788-09t52zix 243 26 contact contact VB cord-007788-09t52zix 243 27 the the DT cord-007788-09t52zix 243 28 clinic clinic NN cord-007788-09t52zix 243 29 or or CC cord-007788-09t52zix 243 30 hospital hospital NN cord-007788-09t52zix 243 31 that that WDT cord-007788-09t52zix 243 32 they -PRON- PRP cord-007788-09t52zix 243 33 have have VBP cord-007788-09t52zix 243 34 a a DT cord-007788-09t52zix 243 35 fever fever NN cord-007788-09t52zix 243 36 thermometer thermometer NN cord-007788-09t52zix 243 37 at at IN cord-007788-09t52zix 243 38 home home NN cord-007788-09t52zix 243 39 , , , cord-007788-09t52zix 243 40 know know VB cord-007788-09t52zix 243 41 when when WRB cord-007788-09t52zix 243 42 to to TO cord-007788-09t52zix 243 43 take take VB cord-007788-09t52zix 243 44 their -PRON- PRP$ cord-007788-09t52zix 243 45 temperature temperature NN cord-007788-09t52zix 243 46 and and CC cord-007788-09t52zix 243 47 are be VBP cord-007788-09t52zix 243 48 aware aware JJ cord-007788-09t52zix 243 49 of of IN cord-007788-09t52zix 243 50 the the DT cord-007788-09t52zix 243 51 level level NN cord-007788-09t52zix 243 52 that that WDT cord-007788-09t52zix 243 53 constitutes constitute VBZ cord-007788-09t52zix 243 54 a a DT cord-007788-09t52zix 243 55 fever fever NN cord-007788-09t52zix 243 56 . . . cord-007788-09t52zix 244 1 Haemorrhagic Haemorrhagic NNP cord-007788-09t52zix 244 2 Cystitis Cystitis NNP cord-007788-09t52zix 244 3 Haemorrhagic Haemorrhagic NNP cord-007788-09t52zix 244 4 cystitis cystitis NN cord-007788-09t52zix 244 5 ( ( -LRB- cord-007788-09t52zix 244 6 HC HC NNP cord-007788-09t52zix 244 7 ) ) -RRB- cord-007788-09t52zix 244 8 is be VBZ cord-007788-09t52zix 244 9 sometimes sometimes RB cord-007788-09t52zix 244 10 seen see VBN cord-007788-09t52zix 244 11 in in IN cord-007788-09t52zix 244 12 haematopoietic haematopoietic JJ cord-007788-09t52zix 244 13 stem stem NN cord-007788-09t52zix 244 14 cell cell NN cord-007788-09t52zix 244 15 transplantation transplantation NN cord-007788-09t52zix 244 16 ( ( -LRB- cord-007788-09t52zix 244 17 HSCT HSCT NNP cord-007788-09t52zix 244 18 ) ) -RRB- cord-007788-09t52zix 244 19 patients patient NNS cord-007788-09t52zix 244 20 and and CC cord-007788-09t52zix 244 21 can can MD cord-007788-09t52zix 244 22 on on IN cord-007788-09t52zix 244 23 its -PRON- PRP$ cord-007788-09t52zix 244 24 own own JJ cord-007788-09t52zix 244 25 or or CC cord-007788-09t52zix 244 26 by by IN cord-007788-09t52zix 244 27 subsequent subsequent JJ cord-007788-09t52zix 244 28 complications complication NNS cord-007788-09t52zix 244 29 cause cause VBP cord-007788-09t52zix 244 30 significant significant JJ cord-007788-09t52zix 244 31 morbidity morbidity NN cord-007788-09t52zix 244 32 and and CC cord-007788-09t52zix 244 33 even even RB cord-007788-09t52zix 244 34 death death NN cord-007788-09t52zix 244 35 . . . cord-007788-09t52zix 245 1 According accord VBG cord-007788-09t52zix 245 2 to to IN cord-007788-09t52zix 245 3 NCI NCI NNP cord-007788-09t52zix 245 4 Dictionary Dictionary NNP cord-007788-09t52zix 245 5 of of IN cord-007788-09t52zix 245 6 Cancer Cancer NNP cord-007788-09t52zix 245 7 Terms Terms NNPS cord-007788-09t52zix 245 8 , , , cord-007788-09t52zix 245 9 it -PRON- PRP cord-007788-09t52zix 245 10 is be VBZ cord-007788-09t52zix 245 11 defined define VBN cord-007788-09t52zix 245 12 as as IN cord-007788-09t52zix 245 13 " " `` cord-007788-09t52zix 245 14 A a DT cord-007788-09t52zix 245 15 condition condition NN cord-007788-09t52zix 245 16 in in IN cord-007788-09t52zix 245 17 which which WDT cord-007788-09t52zix 245 18 the the DT cord-007788-09t52zix 245 19 lining lining NN cord-007788-09t52zix 245 20 of of IN cord-007788-09t52zix 245 21 the the DT cord-007788-09t52zix 245 22 bladder bladder NN cord-007788-09t52zix 245 23 becomes become VBZ cord-007788-09t52zix 245 24 inflamed inflamed JJ cord-007788-09t52zix 245 25 and and CC cord-007788-09t52zix 245 26 starts start VBZ cord-007788-09t52zix 245 27 to to TO cord-007788-09t52zix 245 28 bleed bleed VB cord-007788-09t52zix 245 29 . . . cord-007788-09t52zix 246 1 The the DT cord-007788-09t52zix 246 2 blood blood NN cord-007788-09t52zix 246 3 can can MD cord-007788-09t52zix 246 4 be be VB cord-007788-09t52zix 246 5 seen see VBN cord-007788-09t52zix 246 6 in in IN cord-007788-09t52zix 246 7 the the DT cord-007788-09t52zix 246 8 urine urine NN cord-007788-09t52zix 246 9 . . . cord-007788-09t52zix 247 1 Symptoms symptom NNS cord-007788-09t52zix 247 2 include include VBP cord-007788-09t52zix 247 3 pain pain NN cord-007788-09t52zix 247 4 and and CC cord-007788-09t52zix 247 5 a a DT cord-007788-09t52zix 247 6 burning burn VBG cord-007788-09t52zix 247 7 feeling feeling NN cord-007788-09t52zix 247 8 while while IN cord-007788-09t52zix 247 9 urinating urinate VBG cord-007788-09t52zix 247 10 , , , cord-007788-09t52zix 247 11 feeling feel VBG cord-007788-09t52zix 247 12 a a DT cord-007788-09t52zix 247 13 need need NN cord-007788-09t52zix 247 14 to to TO cord-007788-09t52zix 247 15 urinate urinate VB cord-007788-09t52zix 247 16 often often RB cord-007788-09t52zix 247 17 , , , cord-007788-09t52zix 247 18 and and CC cord-007788-09t52zix 247 19 being be VBG cord-007788-09t52zix 247 20 unable unable JJ cord-007788-09t52zix 247 21 to to TO cord-007788-09t52zix 247 22 control control VB cord-007788-09t52zix 247 23 the the DT cord-007788-09t52zix 247 24 flow flow NN cord-007788-09t52zix 247 25 of of IN cord-007788-09t52zix 247 26 urine urine NN cord-007788-09t52zix 247 27 . . . cord-007788-09t52zix 248 1 Haemorrhagic Haemorrhagic NNP cord-007788-09t52zix 248 2 cystitis cystitis NN cord-007788-09t52zix 248 3 may may MD cord-007788-09t52zix 248 4 be be VB cord-007788-09t52zix 248 5 caused cause VBN cord-007788-09t52zix 248 6 by by IN cord-007788-09t52zix 248 7 anticancer anticancer JJ cord-007788-09t52zix 248 8 drugs drug NNS cord-007788-09t52zix 248 9 , , , cord-007788-09t52zix 248 10 radiation radiation NN cord-007788-09t52zix 248 11 therapy therapy NN cord-007788-09t52zix 248 12 , , , cord-007788-09t52zix 248 13 infection infection NN cord-007788-09t52zix 248 14 , , , cord-007788-09t52zix 248 15 or or CC cord-007788-09t52zix 248 16 being be VBG cord-007788-09t52zix 248 17 exposed expose VBN cord-007788-09t52zix 248 18 to to IN cord-007788-09t52zix 248 19 chemicals chemical NNS cord-007788-09t52zix 248 20 , , , cord-007788-09t52zix 248 21 such such JJ cord-007788-09t52zix 248 22 as as IN cord-007788-09t52zix 248 23 dyes dye NNS cord-007788-09t52zix 248 24 or or CC cord-007788-09t52zix 248 25 insecticides insecticide NNS cord-007788-09t52zix 248 26 " " '' cord-007788-09t52zix 248 27 ( ( -LRB- cord-007788-09t52zix 248 28 NCI NCI NNP cord-007788-09t52zix 248 29 Dictionary Dictionary NNP cord-007788-09t52zix 248 30 of of IN cord-007788-09t52zix 248 31 Cancer Cancer NNP cord-007788-09t52zix 248 32 Terms term NNS cord-007788-09t52zix 248 33 2016 2016 CD cord-007788-09t52zix 248 34 https://www.cancer.gov/publications/ https://www.cancer.gov/publications/ NNP cord-007788-09t52zix 248 35 dictionaries dictionary NNS cord-007788-09t52zix 248 36 / / SYM cord-007788-09t52zix 248 37 cancer cancer NN cord-007788-09t52zix 248 38 - - HYPH cord-007788-09t52zix 248 39 terms?cdrid=695987 terms?cdrid=695987 CD cord-007788-09t52zix 248 40 ) ) -RRB- cord-007788-09t52zix 248 41 . . . cord-007788-09t52zix 249 1 Haematuria Haematuria NNP cord-007788-09t52zix 249 2 can can MD cord-007788-09t52zix 249 3 be be VB cord-007788-09t52zix 249 4 symptomatic symptomatic JJ cord-007788-09t52zix 249 5 or or CC cord-007788-09t52zix 249 6 asymptomatic asymptomatic JJ cord-007788-09t52zix 249 7 . . . cord-007788-09t52zix 250 1 It -PRON- PRP cord-007788-09t52zix 250 2 can can MD cord-007788-09t52zix 250 3 be be VB cord-007788-09t52zix 250 4 described describe VBN cord-007788-09t52zix 250 5 as as IN cord-007788-09t52zix 250 6 microscopic microscopic JJ cord-007788-09t52zix 250 7 ( ( -LRB- cord-007788-09t52zix 250 8 not not RB cord-007788-09t52zix 250 9 visible visible JJ cord-007788-09t52zix 250 10 to to IN cord-007788-09t52zix 250 11 the the DT cord-007788-09t52zix 250 12 eye eye NN cord-007788-09t52zix 250 13 but but CC cord-007788-09t52zix 250 14 detected detect VBD cord-007788-09t52zix 250 15 on on IN cord-007788-09t52zix 250 16 a a DT cord-007788-09t52zix 250 17 dipstick dipstick NN cord-007788-09t52zix 250 18 and and CC cord-007788-09t52zix 250 19 in in IN cord-007788-09t52zix 250 20 the the DT cord-007788-09t52zix 250 21 microscope microscope NN cord-007788-09t52zix 250 22 ) ) -RRB- cord-007788-09t52zix 250 23 or or CC cord-007788-09t52zix 250 24 macroscopic macroscopic JJ cord-007788-09t52zix 250 25 ( ( -LRB- cord-007788-09t52zix 250 26 red red JJ cord-007788-09t52zix 250 27 urine urine NN cord-007788-09t52zix 250 28 or or CC cord-007788-09t52zix 250 29 visible visible JJ cord-007788-09t52zix 250 30 blood blood NN cord-007788-09t52zix 250 31 or or CC cord-007788-09t52zix 250 32 clots clot NNS cord-007788-09t52zix 250 33 ) ) -RRB- cord-007788-09t52zix 251 1 ( ( -LRB- cord-007788-09t52zix 251 2 Table table NN cord-007788-09t52zix 251 3 9 9 CD cord-007788-09t52zix 251 4 .3 .3 CD cord-007788-09t52zix 251 5 ) ) -RRB- cord-007788-09t52zix 251 6 . . . cord-007788-09t52zix 252 1 Normally normally RB cord-007788-09t52zix 252 2 about about IN cord-007788-09t52zix 252 3 1 1 CD cord-007788-09t52zix 252 4 million million CD cord-007788-09t52zix 252 5 erythrocytes erythrocyte NNS cord-007788-09t52zix 252 6 are be VBP cord-007788-09t52zix 252 7 excreted excrete VBN cord-007788-09t52zix 252 8 daily daily RB cord-007788-09t52zix 252 9 in in IN cord-007788-09t52zix 252 10 the the DT cord-007788-09t52zix 252 11 urine urine NN cord-007788-09t52zix 252 12 . . . cord-007788-09t52zix 253 1 This this DT cord-007788-09t52zix 253 2 is be VBZ cord-007788-09t52zix 253 3 equal equal JJ cord-007788-09t52zix 253 4 to to IN cord-007788-09t52zix 253 5 one one CD cord-007788-09t52zix 253 6 to to TO cord-007788-09t52zix 253 7 three three CD cord-007788-09t52zix 253 8 erythrocytes erythrocyte NNS cord-007788-09t52zix 253 9 per per IN cord-007788-09t52zix 253 10 highpower highpower NN cord-007788-09t52zix 253 11 field field NN cord-007788-09t52zix 253 12 ( ( -LRB- cord-007788-09t52zix 253 13 magnification magnification NN cord-007788-09t52zix 253 14 ×400 ×400 CD cord-007788-09t52zix 253 15 ) ) -RRB- cord-007788-09t52zix 253 16 under under IN cord-007788-09t52zix 253 17 the the DT cord-007788-09t52zix 253 18 microscope microscope NN cord-007788-09t52zix 253 19 . . . cord-007788-09t52zix 254 1 Haematuria Haematuria NNP cord-007788-09t52zix 254 2 is be VBZ cord-007788-09t52zix 254 3 defined define VBN cord-007788-09t52zix 254 4 as as IN cord-007788-09t52zix 254 5 abnormal abnormal JJ cord-007788-09t52zix 254 6 presence presence NN cord-007788-09t52zix 254 7 of of IN cord-007788-09t52zix 254 8 blood blood NN cord-007788-09t52zix 254 9 in in IN cord-007788-09t52zix 254 10 the the DT cord-007788-09t52zix 254 11 urine urine NN cord-007788-09t52zix 254 12 , , , cord-007788-09t52zix 254 13 i.e. i.e. FW cord-007788-09t52zix 254 14 more more JJR cord-007788-09t52zix 254 15 than than IN cord-007788-09t52zix 254 16 three three CD cord-007788-09t52zix 254 17 erythrocytes erythrocyte NNS cord-007788-09t52zix 254 18 per per IN cord-007788-09t52zix 254 19 high high JJ cord-007788-09t52zix 254 20 - - HYPH cord-007788-09t52zix 254 21 power power NN cord-007788-09t52zix 254 22 field field NN cord-007788-09t52zix 254 23 in in IN cord-007788-09t52zix 254 24 the the DT cord-007788-09t52zix 254 25 micro micro JJ cord-007788-09t52zix 254 26 - - JJ cord-007788-09t52zix 254 27 scope scope NN cord-007788-09t52zix 254 28 . . . cord-007788-09t52zix 255 1 To to TO cord-007788-09t52zix 255 2 be be VB cord-007788-09t52zix 255 3 confirmed confirm VBN cord-007788-09t52zix 255 4 as as IN cord-007788-09t52zix 255 5 microscopic microscopic JJ cord-007788-09t52zix 255 6 haematuria haematuria NNS cord-007788-09t52zix 255 7 , , , cord-007788-09t52zix 255 8 two two CD cord-007788-09t52zix 255 9 positive positive JJ cord-007788-09t52zix 255 10 samples sample NNS cord-007788-09t52zix 255 11 on on IN cord-007788-09t52zix 255 12 consecutive consecutive JJ cord-007788-09t52zix 255 13 days day NNS cord-007788-09t52zix 255 14 are be VBP cord-007788-09t52zix 255 15 needed need VBN cord-007788-09t52zix 255 16 . . . cord-007788-09t52zix 256 1 The the DT cord-007788-09t52zix 256 2 haematuria haematuria NNS cord-007788-09t52zix 256 3 can can MD cord-007788-09t52zix 256 4 be be VB cord-007788-09t52zix 256 5 visually visually RB cord-007788-09t52zix 256 6 detected detect VBN cord-007788-09t52zix 256 7 ( ( -LRB- cord-007788-09t52zix 256 8 macroscopic macroscopic JJ cord-007788-09t52zix 256 9 ) ) -RRB- cord-007788-09t52zix 256 10 as as IN cord-007788-09t52zix 256 11 red red JJ cord-007788-09t52zix 256 12 urine urine NN cord-007788-09t52zix 256 13 at at IN cord-007788-09t52zix 256 14 levels level NNS cord-007788-09t52zix 257 1 as as RB cord-007788-09t52zix 257 2 low low JJ cord-007788-09t52zix 257 3 as as IN cord-007788-09t52zix 257 4 1 1 CD cord-007788-09t52zix 257 5 mL ml NN cord-007788-09t52zix 257 6 blood blood NN cord-007788-09t52zix 257 7 per per IN cord-007788-09t52zix 257 8 litre litre NN cord-007788-09t52zix 257 9 urine urine NN cord-007788-09t52zix 257 10 . . . cord-007788-09t52zix 258 1 The the DT cord-007788-09t52zix 258 2 visible visible JJ cord-007788-09t52zix 258 3 blood blood NN cord-007788-09t52zix 258 4 does do VBZ cord-007788-09t52zix 258 5 however however RB cord-007788-09t52zix 258 6 not not RB cord-007788-09t52zix 258 7 necessarily necessarily RB cord-007788-09t52zix 258 8 correspond correspond VB cord-007788-09t52zix 258 9 to to IN cord-007788-09t52zix 258 10 the the DT cord-007788-09t52zix 258 11 degree degree NN cord-007788-09t52zix 258 12 of of IN cord-007788-09t52zix 258 13 blood blood NN cord-007788-09t52zix 258 14 loss loss NN cord-007788-09t52zix 258 15 through through IN cord-007788-09t52zix 258 16 the the DT cord-007788-09t52zix 258 17 urine urine NN cord-007788-09t52zix 258 18 . . . cord-007788-09t52zix 259 1 Red red JJ cord-007788-09t52zix 259 2 urine urine NN cord-007788-09t52zix 259 3 may may MD cord-007788-09t52zix 259 4 also also RB cord-007788-09t52zix 259 5 have have VB cord-007788-09t52zix 259 6 other other JJ cord-007788-09t52zix 259 7 causes cause NNS cord-007788-09t52zix 259 8 which which WDT cord-007788-09t52zix 259 9 will will MD cord-007788-09t52zix 259 10 not not RB cord-007788-09t52zix 259 11 be be VB cord-007788-09t52zix 259 12 described describe VBN cord-007788-09t52zix 259 13 here here RB cord-007788-09t52zix 259 14 . . . cord-007788-09t52zix 260 1 Cystitis Cystitis NNP cord-007788-09t52zix 260 2 is be VBZ cord-007788-09t52zix 260 3 the the DT cord-007788-09t52zix 260 4 term term NN cord-007788-09t52zix 260 5 used use VBN cord-007788-09t52zix 260 6 to to TO cord-007788-09t52zix 260 7 describe describe VB cord-007788-09t52zix 260 8 inflammation inflammation NN cord-007788-09t52zix 260 9 of of IN cord-007788-09t52zix 260 10 the the DT cord-007788-09t52zix 260 11 bladder bladder NN cord-007788-09t52zix 260 12 . . . cord-007788-09t52zix 261 1 The the DT cord-007788-09t52zix 261 2 inflammation inflammation NN cord-007788-09t52zix 261 3 can can MD cord-007788-09t52zix 261 4 be be VB cord-007788-09t52zix 261 5 caused cause VBN cord-007788-09t52zix 261 6 by by IN cord-007788-09t52zix 261 7 an an DT cord-007788-09t52zix 261 8 infection infection NN cord-007788-09t52zix 261 9 or or CC cord-007788-09t52zix 261 10 as as IN cord-007788-09t52zix 261 11 a a DT cord-007788-09t52zix 261 12 reaction reaction NN cord-007788-09t52zix 261 13 to to IN cord-007788-09t52zix 261 14 certain certain JJ cord-007788-09t52zix 261 15 drugs drug NNS cord-007788-09t52zix 261 16 or or CC cord-007788-09t52zix 261 17 radiation radiation NN cord-007788-09t52zix 261 18 therapy therapy NN cord-007788-09t52zix 261 19 . . . cord-007788-09t52zix 262 1 The the DT cord-007788-09t52zix 262 2 following follow VBG cord-007788-09t52zix 262 3 symptoms symptom NNS cord-007788-09t52zix 262 4 may may MD cord-007788-09t52zix 262 5 be be VB cord-007788-09t52zix 262 6 seen see VBN cord-007788-09t52zix 262 7 in in IN cord-007788-09t52zix 262 8 all all DT cord-007788-09t52zix 262 9 types type NNS cord-007788-09t52zix 262 10 of of IN cord-007788-09t52zix 262 11 cystitis cystitis NN cord-007788-09t52zix 262 12 : : : cord-007788-09t52zix 262 13 • • NNP cord-007788-09t52zix 263 1 Urinary urinary JJ cord-007788-09t52zix 263 2 urgency urgency NN cord-007788-09t52zix 263 3 and and CC cord-007788-09t52zix 263 4 frequency frequency NN cord-007788-09t52zix 264 1 • • NNP cord-007788-09t52zix 265 1 Burning burn VBG cord-007788-09t52zix 265 2 or or CC cord-007788-09t52zix 265 3 stinging stinging JJ cord-007788-09t52zix 265 4 with with IN cord-007788-09t52zix 265 5 urination urination NN cord-007788-09t52zix 265 6 or or CC cord-007788-09t52zix 266 1 right right RB cord-007788-09t52zix 266 2 after after IN cord-007788-09t52zix 266 3 • • NNP cord-007788-09t52zix 266 4 Pain Pain NNP cord-007788-09t52zix 266 5 , , , cord-007788-09t52zix 266 6 dysuria dysuria FW cord-007788-09t52zix 266 7 ( ( -LRB- cord-007788-09t52zix 266 8 painful painful JJ cord-007788-09t52zix 266 9 urination urination NN cord-007788-09t52zix 266 10 ) ) -RRB- cord-007788-09t52zix 266 11 , , , cord-007788-09t52zix 266 12 lower low JJR cord-007788-09t52zix 266 13 abdominal abdominal JJ cord-007788-09t52zix 266 14 or or CC cord-007788-09t52zix 266 15 supra supra JJ cord-007788-09t52zix 266 16 - - HYPH cord-007788-09t52zix 266 17 pubic pubic NN cord-007788-09t52zix 266 18 pain pain NN cord-007788-09t52zix 267 1 • • NNP cord-007788-09t52zix 268 1 Nocturia Nocturia NNP cord-007788-09t52zix 268 2 , , , cord-007788-09t52zix 268 3 when when WRB cord-007788-09t52zix 268 4 sleep sleep NN cord-007788-09t52zix 268 5 is be VBZ cord-007788-09t52zix 268 6 disturbed disturb VBN cord-007788-09t52zix 268 7 twice twice RB cord-007788-09t52zix 268 8 or or CC cord-007788-09t52zix 268 9 more more JJR cord-007788-09t52zix 268 10 at at IN cord-007788-09t52zix 268 11 night night NN cord-007788-09t52zix 268 12 due due IN cord-007788-09t52zix 268 13 to to IN cord-007788-09t52zix 268 14 a a DT cord-007788-09t52zix 268 15 need need NN cord-007788-09t52zix 268 16 to to TO cord-007788-09t52zix 268 17 urinate urinate VB cord-007788-09t52zix 268 18 • • CD cord-007788-09t52zix 268 19 Urinary urinary JJ cord-007788-09t52zix 268 20 incontinence incontinence NN cord-007788-09t52zix 269 1 • • NNP cord-007788-09t52zix 270 1 General general JJ cord-007788-09t52zix 270 2 feeling feeling NN cord-007788-09t52zix 270 3 of of IN cord-007788-09t52zix 270 4 illness illness NN cord-007788-09t52zix 270 5 Reported report VBN cord-007788-09t52zix 270 6 incidences incidence NNS cord-007788-09t52zix 270 7 of of IN cord-007788-09t52zix 270 8 HC HC NNP cord-007788-09t52zix 270 9 after after IN cord-007788-09t52zix 270 10 HSCT HSCT NNP cord-007788-09t52zix 270 11 range range VBP cord-007788-09t52zix 270 12 between between IN cord-007788-09t52zix 270 13 5 5 CD cord-007788-09t52zix 270 14 % % NN cord-007788-09t52zix 270 15 and and CC cord-007788-09t52zix 270 16 70 70 CD cord-007788-09t52zix 270 17 % % NN cord-007788-09t52zix 270 18 depending depend VBG cord-007788-09t52zix 270 19 on on IN cord-007788-09t52zix 270 20 risk risk NN cord-007788-09t52zix 270 21 factors factor NNS cord-007788-09t52zix 270 22 and and CC cord-007788-09t52zix 270 23 use use NN cord-007788-09t52zix 270 24 of of IN cord-007788-09t52zix 270 25 preventive preventive JJ cord-007788-09t52zix 270 26 measures measure NNS cord-007788-09t52zix 270 27 or or CC cord-007788-09t52zix 270 28 not not RB cord-007788-09t52zix 270 29 , , , cord-007788-09t52zix 270 30 but but CC cord-007788-09t52zix 270 31 most most JJS cord-007788-09t52zix 270 32 materials material NNS cord-007788-09t52zix 270 33 describe describe VBP cord-007788-09t52zix 270 34 an an DT cord-007788-09t52zix 270 35 incidence incidence NN cord-007788-09t52zix 270 36 between between IN cord-007788-09t52zix 270 37 5 5 CD cord-007788-09t52zix 270 38 % % NN cord-007788-09t52zix 270 39 and and CC cord-007788-09t52zix 270 40 30 30 CD cord-007788-09t52zix 270 41 % % NN cord-007788-09t52zix 270 42 . . . cord-007788-09t52zix 271 1 The the DT cord-007788-09t52zix 271 2 pathogenesis pathogenesis NN cord-007788-09t52zix 271 3 leading lead VBG cord-007788-09t52zix 271 4 to to IN cord-007788-09t52zix 271 5 HC HC NNP cord-007788-09t52zix 271 6 is be VBZ cord-007788-09t52zix 271 7 not not RB cord-007788-09t52zix 271 8 completely completely RB cord-007788-09t52zix 271 9 known know VBN cord-007788-09t52zix 271 10 but but CC cord-007788-09t52zix 271 11 is be VBZ cord-007788-09t52zix 271 12 likely likely JJ cord-007788-09t52zix 271 13 to to TO cord-007788-09t52zix 271 14 be be VB cord-007788-09t52zix 271 15 multifactorial multifactorial JJ cord-007788-09t52zix 271 16 . . . cord-007788-09t52zix 272 1 The the DT cord-007788-09t52zix 272 2 onset onset NN cord-007788-09t52zix 272 3 is be VBZ cord-007788-09t52zix 272 4 seen see VBN cord-007788-09t52zix 272 5 either either CC cord-007788-09t52zix 272 6 early early JJ cord-007788-09t52zix 272 7 , , , cord-007788-09t52zix 272 8 within within IN cord-007788-09t52zix 272 9 the the DT cord-007788-09t52zix 272 10 two two CD cord-007788-09t52zix 272 11 first first JJ cord-007788-09t52zix 272 12 weeks week NNS cord-007788-09t52zix 272 13 after after IN cord-007788-09t52zix 272 14 start start NN cord-007788-09t52zix 272 15 of of IN cord-007788-09t52zix 272 16 conditioning conditioning NN cord-007788-09t52zix 272 17 treatment treatment NN cord-007788-09t52zix 272 18 , , , cord-007788-09t52zix 272 19 or or CC cord-007788-09t52zix 272 20 late late RB cord-007788-09t52zix 272 21 , , , cord-007788-09t52zix 272 22 more more JJR cord-007788-09t52zix 272 23 than than IN cord-007788-09t52zix 272 24 2 2 CD cord-007788-09t52zix 272 25 weeks week NNS cord-007788-09t52zix 272 26 after after IN cord-007788-09t52zix 272 27 HSCT HSCT NNP cord-007788-09t52zix 272 28 . . . cord-007788-09t52zix 273 1 Conditioning conditioning NN cord-007788-09t52zix 273 2 treatment treatment NN cord-007788-09t52zix 273 3 with with IN cord-007788-09t52zix 273 4 chemotherapy chemotherapy NN cord-007788-09t52zix 273 5 , , , cord-007788-09t52zix 273 6 irradiation irradiation NN cord-007788-09t52zix 273 7 , , , cord-007788-09t52zix 273 8 cytopenia cytopenia NNP cord-007788-09t52zix 273 9 , , , cord-007788-09t52zix 273 10 viral viral JJ cord-007788-09t52zix 273 11 infections infection NNS cord-007788-09t52zix 273 12 due due JJ cord-007788-09t52zix 273 13 to to IN cord-007788-09t52zix 273 14 immunosuppression immunosuppression NN cord-007788-09t52zix 273 15 and and CC cord-007788-09t52zix 273 16 alloimmune alloimmune JJ cord-007788-09t52zix 273 17 reactions reaction NNS cord-007788-09t52zix 273 18 ( ( -LRB- cord-007788-09t52zix 273 19 immunisation immunisation NN cord-007788-09t52zix 273 20 by by IN cord-007788-09t52zix 273 21 development development NN cord-007788-09t52zix 273 22 of of IN cord-007788-09t52zix 273 23 antibodies antibody NNS cord-007788-09t52zix 273 24 in in IN cord-007788-09t52zix 273 25 response response NN cord-007788-09t52zix 273 26 to to IN cord-007788-09t52zix 273 27 an an DT cord-007788-09t52zix 273 28 antigen antigen NN cord-007788-09t52zix 273 29 , , , cord-007788-09t52zix 273 30 i.e. i.e. FW cord-007788-09t52zix 273 31 a a DT cord-007788-09t52zix 273 32 protein protein NN cord-007788-09t52zix 273 33 from from IN cord-007788-09t52zix 273 34 a a DT cord-007788-09t52zix 273 35 donor donor NN cord-007788-09t52zix 273 36 , , . cord-007788-09t52zix 274 1 e.g. e.g. RB cord-007788-09t52zix 274 2 by by IN cord-007788-09t52zix 274 3 receiving receive VBG cord-007788-09t52zix 274 4 HSCT HSCT NNP cord-007788-09t52zix 274 5 or or CC cord-007788-09t52zix 274 6 transfusion transfusion NN cord-007788-09t52zix 274 7 ) ) -RRB- cord-007788-09t52zix 274 8 may may MD cord-007788-09t52zix 274 9 all all RB cord-007788-09t52zix 274 10 contribute contribute VB cord-007788-09t52zix 274 11 to to IN cord-007788-09t52zix 274 12 HC HC NNP cord-007788-09t52zix 274 13 in in IN cord-007788-09t52zix 274 14 the the DT cord-007788-09t52zix 274 15 posttransplant posttransplant NN cord-007788-09t52zix 274 16 period period NN cord-007788-09t52zix 274 17 . . . cord-007788-09t52zix 275 1 Higher high JJR cord-007788-09t52zix 275 2 incidence incidence NN cord-007788-09t52zix 275 3 of of IN cord-007788-09t52zix 275 4 late late JJ cord-007788-09t52zix 275 5 - - HYPH cord-007788-09t52zix 275 6 onset onset NN cord-007788-09t52zix 275 7 HC HC NNP cord-007788-09t52zix 275 8 in in IN cord-007788-09t52zix 275 9 HSCT HSCT NNP cord-007788-09t52zix 275 10 with with IN cord-007788-09t52zix 275 11 unrelated unrelated JJ cord-007788-09t52zix 275 12 donors donor NNS cord-007788-09t52zix 275 13 , , , cord-007788-09t52zix 275 14 older old JJR cord-007788-09t52zix 275 15 patients patient NNS cord-007788-09t52zix 275 16 , , , cord-007788-09t52zix 275 17 and and CC cord-007788-09t52zix 275 18 in in IN cord-007788-09t52zix 275 19 patients patient NNS cord-007788-09t52zix 275 20 with with IN cord-007788-09t52zix 275 21 graft graft NN cord-007788-09t52zix 275 22 versus versus IN cord-007788-09t52zix 275 23 host host NN cord-007788-09t52zix 275 24 disease disease NN cord-007788-09t52zix 275 25 ( ( -LRB- cord-007788-09t52zix 275 26 GvHD GvHD NNP cord-007788-09t52zix 275 27 ) ) -RRB- cord-007788-09t52zix 275 28 and and CC cord-007788-09t52zix 275 29 thrombocytopenia thrombocytopenia NN cord-007788-09t52zix 275 30 does do VBZ cord-007788-09t52zix 275 31 support support VB cord-007788-09t52zix 275 32 the the DT cord-007788-09t52zix 275 33 conclusion conclusion NN cord-007788-09t52zix 275 34 that that IN cord-007788-09t52zix 275 35 the the DT cord-007788-09t52zix 275 36 pathogenesis pathogenesis NN cord-007788-09t52zix 275 37 is be VBZ cord-007788-09t52zix 275 38 multifactorial multifactorial JJ cord-007788-09t52zix 275 39 ( ( -LRB- cord-007788-09t52zix 275 40 de de NNP cord-007788-09t52zix 275 41 Padua Padua NNP cord-007788-09t52zix 275 42 Silva Silva NNP cord-007788-09t52zix 275 43 2010 2010 CD cord-007788-09t52zix 275 44 ) ) -RRB- cord-007788-09t52zix 275 45 . . . cord-007788-09t52zix 276 1 Early early JJ cord-007788-09t52zix 276 2 - - HYPH cord-007788-09t52zix 276 3 onset onset NN cord-007788-09t52zix 276 4 HC HC NNP cord-007788-09t52zix 276 5 is be VBZ cord-007788-09t52zix 276 6 usually usually RB cord-007788-09t52zix 276 7 a a DT cord-007788-09t52zix 276 8 direct direct JJ cord-007788-09t52zix 276 9 and and CC cord-007788-09t52zix 276 10 immediate immediate JJ cord-007788-09t52zix 276 11 effect effect NN cord-007788-09t52zix 276 12 of of IN cord-007788-09t52zix 276 13 the the DT cord-007788-09t52zix 276 14 conditioning conditioning NN cord-007788-09t52zix 276 15 treatment treatment NN cord-007788-09t52zix 276 16 . . . cord-007788-09t52zix 277 1 Conditioning conditioning NN cord-007788-09t52zix 277 2 therapy therapy NN cord-007788-09t52zix 277 3 for for IN cord-007788-09t52zix 277 4 HSCT HSCT NNP cord-007788-09t52zix 277 5 often often RB cord-007788-09t52zix 277 6 contains contain VBZ cord-007788-09t52zix 277 7 one one CD cord-007788-09t52zix 277 8 or or CC cord-007788-09t52zix 277 9 more more RBR cord-007788-09t52zix 277 10 alkylating alkylating JJ cord-007788-09t52zix 277 11 agent agent NN cord-007788-09t52zix 277 12 . . . cord-007788-09t52zix 278 1 Cyclophosphamide Cyclophosphamide NNP cord-007788-09t52zix 278 2 , , , cord-007788-09t52zix 278 3 ifosfamide ifosfamide NNP cord-007788-09t52zix 278 4 , , , cord-007788-09t52zix 278 5 busulfan busulfan NNP cord-007788-09t52zix 278 6 , , , cord-007788-09t52zix 278 7 melphalan melphalan NNP cord-007788-09t52zix 278 8 and and CC cord-007788-09t52zix 278 9 thiotepa thiotepa NNP cord-007788-09t52zix 278 10 are be VBP cord-007788-09t52zix 278 11 among among IN cord-007788-09t52zix 278 12 the the DT cord-007788-09t52zix 278 13 most most RBS cord-007788-09t52zix 278 14 commonly commonly RB cord-007788-09t52zix 278 15 used use VBN cord-007788-09t52zix 278 16 drugs drug NNS cord-007788-09t52zix 278 17 in in IN cord-007788-09t52zix 278 18 conditioning conditioning NN cord-007788-09t52zix 278 19 regimens regimen NNS cord-007788-09t52zix 278 20 and and CC cord-007788-09t52zix 278 21 the the DT cord-007788-09t52zix 278 22 major major JJ cord-007788-09t52zix 278 23 drug drug NN cord-007788-09t52zix 278 24 - - HYPH cord-007788-09t52zix 278 25 related relate VBN cord-007788-09t52zix 278 26 cause cause NN cord-007788-09t52zix 278 27 of of IN cord-007788-09t52zix 278 28 HC HC NNP cord-007788-09t52zix 278 29 . . . cord-007788-09t52zix 279 1 Use use NN cord-007788-09t52zix 279 2 of of IN cord-007788-09t52zix 279 3 other other JJ cord-007788-09t52zix 279 4 alkylating alkylating JJ cord-007788-09t52zix 279 5 agents agent NNS cord-007788-09t52zix 279 6 and and CC cord-007788-09t52zix 279 7 etoposide etoposide RB cord-007788-09t52zix 279 8 may may MD cord-007788-09t52zix 279 9 also also RB cord-007788-09t52zix 279 10 increase increase VB cord-007788-09t52zix 279 11 the the DT cord-007788-09t52zix 279 12 risk risk NN cord-007788-09t52zix 279 13 of of IN cord-007788-09t52zix 279 14 HC HC NNP cord-007788-09t52zix 279 15 . . . cord-007788-09t52zix 280 1 When when WRB cord-007788-09t52zix 280 2 cyclophosphamide cyclophosphamide JJ cord-007788-09t52zix 280 3 or or CC cord-007788-09t52zix 280 4 ifosfamide ifosfamide NNP cord-007788-09t52zix 280 5 is be VBZ cord-007788-09t52zix 280 6 metabolised metabolise VBN cord-007788-09t52zix 280 7 in in IN cord-007788-09t52zix 280 8 the the DT cord-007788-09t52zix 280 9 body body NN cord-007788-09t52zix 280 10 , , , cord-007788-09t52zix 280 11 it -PRON- PRP cord-007788-09t52zix 280 12 produces produce VBZ cord-007788-09t52zix 280 13 a a DT cord-007788-09t52zix 280 14 metabolite metabolite NN cord-007788-09t52zix 280 15 called call VBN cord-007788-09t52zix 280 16 acrolein acrolein NN cord-007788-09t52zix 280 17 . . . cord-007788-09t52zix 281 1 Acrolein acrolein NN cord-007788-09t52zix 281 2 will will MD cord-007788-09t52zix 281 3 cause cause VB cord-007788-09t52zix 281 4 direct direct JJ cord-007788-09t52zix 281 5 toxicity toxicity NN cord-007788-09t52zix 281 6 to to IN cord-007788-09t52zix 281 7 the the DT cord-007788-09t52zix 281 8 inner inner JJ cord-007788-09t52zix 281 9 lining lining NN cord-007788-09t52zix 281 10 of of IN cord-007788-09t52zix 281 11 the the DT cord-007788-09t52zix 281 12 urinary urinary JJ cord-007788-09t52zix 281 13 tract tract NN cord-007788-09t52zix 281 14 , , , cord-007788-09t52zix 281 15 the the DT cord-007788-09t52zix 281 16 urothelium urothelium NN cord-007788-09t52zix 281 17 . . . cord-007788-09t52zix 282 1 The the DT cord-007788-09t52zix 282 2 degree degree NN cord-007788-09t52zix 282 3 of of IN cord-007788-09t52zix 282 4 damage damage NN cord-007788-09t52zix 282 5 is be VBZ cord-007788-09t52zix 282 6 dose dose JJ cord-007788-09t52zix 282 7 dependent dependent JJ cord-007788-09t52zix 282 8 , , , cord-007788-09t52zix 282 9 and and CC cord-007788-09t52zix 282 10 the the DT cord-007788-09t52zix 282 11 toxicity toxicity NN cord-007788-09t52zix 282 12 may may MD cord-007788-09t52zix 282 13 increase increase VB cord-007788-09t52zix 282 14 with with IN cord-007788-09t52zix 282 15 previous previous JJ cord-007788-09t52zix 282 16 or or CC cord-007788-09t52zix 282 17 concomitant concomitant JJ cord-007788-09t52zix 282 18 radiation radiation NN cord-007788-09t52zix 282 19 therapy therapy NN cord-007788-09t52zix 282 20 and and CC cord-007788-09t52zix 282 21 if if IN cord-007788-09t52zix 282 22 busulfan busulfan NN cord-007788-09t52zix 282 23 is be VBZ cord-007788-09t52zix 282 24 included include VBN cord-007788-09t52zix 282 25 in in IN cord-007788-09t52zix 282 26 the the DT cord-007788-09t52zix 282 27 conditioning conditioning NN cord-007788-09t52zix 282 28 regimen regimen NN cord-007788-09t52zix 282 29 together together RB cord-007788-09t52zix 282 30 with with IN cord-007788-09t52zix 282 31 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 282 32 . . . cord-007788-09t52zix 283 1 The the DT cord-007788-09t52zix 283 2 time time NN cord-007788-09t52zix 283 3 of of IN cord-007788-09t52zix 283 4 duration duration NN cord-007788-09t52zix 283 5 that that WDT cord-007788-09t52zix 283 6 acrolein acrolein NN cord-007788-09t52zix 283 7 is be VBZ cord-007788-09t52zix 283 8 exposed expose VBN cord-007788-09t52zix 283 9 to to IN cord-007788-09t52zix 283 10 the the DT cord-007788-09t52zix 283 11 bladder bladder NN cord-007788-09t52zix 283 12 also also RB cord-007788-09t52zix 283 13 contributes contribute VBZ cord-007788-09t52zix 283 14 to to IN cord-007788-09t52zix 283 15 the the DT cord-007788-09t52zix 283 16 degree degree NN cord-007788-09t52zix 283 17 of of IN cord-007788-09t52zix 283 18 damage damage NN cord-007788-09t52zix 283 19 . . . cord-007788-09t52zix 284 1 For for IN cord-007788-09t52zix 284 2 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 284 3 , , , cord-007788-09t52zix 284 4 the the DT cord-007788-09t52zix 284 5 maximal maximal JJ cord-007788-09t52zix 284 6 concentration concentration NN cord-007788-09t52zix 284 7 of of IN cord-007788-09t52zix 284 8 active active JJ cord-007788-09t52zix 284 9 metabolites metabolite NNS cord-007788-09t52zix 284 10 is be VBZ cord-007788-09t52zix 284 11 reached reach VBN cord-007788-09t52zix 284 12 after after IN cord-007788-09t52zix 284 13 2 2 CD cord-007788-09t52zix 284 14 - - SYM cord-007788-09t52zix 284 15 4 4 CD cord-007788-09t52zix 284 16 h h NN cord-007788-09t52zix 284 17 of of IN cord-007788-09t52zix 284 18 oral oral JJ cord-007788-09t52zix 284 19 or or CC cord-007788-09t52zix 284 20 intravenous intravenous JJ cord-007788-09t52zix 284 21 administration administration NN cord-007788-09t52zix 284 22 . . . cord-007788-09t52zix 285 1 Most Most JJS cord-007788-09t52zix 285 2 of of IN cord-007788-09t52zix 285 3 the the DT cord-007788-09t52zix 285 4 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 285 5 , , , cord-007788-09t52zix 285 6 35 35 CD cord-007788-09t52zix 285 7 - - SYM cord-007788-09t52zix 285 8 80 80 CD cord-007788-09t52zix 285 9 % % NN cord-007788-09t52zix 285 10 of of IN cord-007788-09t52zix 285 11 the the DT cord-007788-09t52zix 285 12 dose dose NN cord-007788-09t52zix 285 13 , , , cord-007788-09t52zix 285 14 is be VBZ cord-007788-09t52zix 285 15 excreted excrete VBN cord-007788-09t52zix 285 16 in in IN cord-007788-09t52zix 285 17 the the DT cord-007788-09t52zix 285 18 urine urine NN cord-007788-09t52zix 285 19 as as IN cord-007788-09t52zix 285 20 metabolites metabolite NNS cord-007788-09t52zix 285 21 , , , cord-007788-09t52zix 285 22 and and CC cord-007788-09t52zix 285 23 up up IN cord-007788-09t52zix 285 24 to to TO cord-007788-09t52zix 285 25 20 20 CD cord-007788-09t52zix 285 26 % % NN cord-007788-09t52zix 285 27 is be VBZ cord-007788-09t52zix 285 28 excreted excrete VBN cord-007788-09t52zix 285 29 as as IN cord-007788-09t52zix 285 30 intact intact JJ cord-007788-09t52zix 285 31 drug drug NN cord-007788-09t52zix 285 32 ( ( -LRB- cord-007788-09t52zix 285 33 Hassan Hassan NNP cord-007788-09t52zix 285 34 and and CC cord-007788-09t52zix 285 35 Ljungman Ljungman NNP cord-007788-09t52zix 285 36 2003 2003 CD cord-007788-09t52zix 285 37 ) ) -RRB- cord-007788-09t52zix 285 38 . . . cord-007788-09t52zix 286 1 In in IN cord-007788-09t52zix 286 2 patients patient NNS cord-007788-09t52zix 286 3 with with IN cord-007788-09t52zix 286 4 decreased decreased JJ cord-007788-09t52zix 286 5 renal renal JJ cord-007788-09t52zix 286 6 function function NN cord-007788-09t52zix 286 7 , , , cord-007788-09t52zix 286 8 particularly particularly RB cord-007788-09t52zix 286 9 in in IN cord-007788-09t52zix 286 10 severe severe JJ cord-007788-09t52zix 286 11 cases case NNS cord-007788-09t52zix 286 12 , , , cord-007788-09t52zix 286 13 decreased decrease VBD cord-007788-09t52zix 286 14 renal renal JJ cord-007788-09t52zix 286 15 excretion excretion NN cord-007788-09t52zix 286 16 may may MD cord-007788-09t52zix 286 17 result result VB cord-007788-09t52zix 286 18 in in IN cord-007788-09t52zix 286 19 increased increase VBN cord-007788-09t52zix 286 20 plasma plasma NN cord-007788-09t52zix 286 21 levels level NNS cord-007788-09t52zix 286 22 of of IN cord-007788-09t52zix 286 23 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 286 24 and and CC cord-007788-09t52zix 286 25 its -PRON- PRP$ cord-007788-09t52zix 286 26 metabolites metabolite NNS cord-007788-09t52zix 286 27 . . . cord-007788-09t52zix 287 1 This this DT cord-007788-09t52zix 287 2 can can MD cord-007788-09t52zix 287 3 cause cause VB cord-007788-09t52zix 287 4 increased increase VBN cord-007788-09t52zix 287 5 toxicity toxicity NN cord-007788-09t52zix 287 6 . . . cord-007788-09t52zix 288 1 The the DT cord-007788-09t52zix 288 2 following follow VBG cord-007788-09t52zix 288 3 substances substance NNS cord-007788-09t52zix 288 4 may may MD cord-007788-09t52zix 288 5 also also RB cord-007788-09t52zix 288 6 increase increase VB cord-007788-09t52zix 288 7 the the DT cord-007788-09t52zix 288 8 concentration concentration NN cord-007788-09t52zix 288 9 of of IN cord-007788-09t52zix 288 10 toxic toxic JJ cord-007788-09t52zix 288 11 metabolites metabolite NNS cord-007788-09t52zix 288 12 , , , cord-007788-09t52zix 288 13 possibly possibly RB cord-007788-09t52zix 288 14 through through IN cord-007788-09t52zix 288 15 inhibited inhibited JJ cord-007788-09t52zix 288 16 breakdown breakdown NN cord-007788-09t52zix 288 17 or or CC cord-007788-09t52zix 288 18 decreased decrease VBD cord-007788-09t52zix 288 19 renal renal JJ cord-007788-09t52zix 288 20 excretion excretion NN cord-007788-09t52zix 288 21 : : : cord-007788-09t52zix 288 22 allopurinol allopurinol NN cord-007788-09t52zix 288 23 , , , cord-007788-09t52zix 288 24 cimetidine cimetidine NN cord-007788-09t52zix 288 25 , , , cord-007788-09t52zix 288 26 hydrochlorothiazide hydrochlorothiazide NN cord-007788-09t52zix 288 27 and and CC cord-007788-09t52zix 288 28 HIV HIV NNP cord-007788-09t52zix 288 29 protease protease NN cord-007788-09t52zix 288 30 inhibitors inhibitor NNS cord-007788-09t52zix 288 31 . . . cord-007788-09t52zix 289 1 When when WRB cord-007788-09t52zix 289 2 HC HC NNP cord-007788-09t52zix 289 3 occurs occur VBZ cord-007788-09t52zix 289 4 more more JJR cord-007788-09t52zix 289 5 than than IN cord-007788-09t52zix 289 6 2 2 CD cord-007788-09t52zix 289 7 weeks week NNS cord-007788-09t52zix 289 8 after after IN cord-007788-09t52zix 289 9 HSCT HSCT NNP cord-007788-09t52zix 289 10 , , , cord-007788-09t52zix 289 11 a a DT cord-007788-09t52zix 289 12 common common JJ cord-007788-09t52zix 289 13 cause cause NN cord-007788-09t52zix 289 14 in in IN cord-007788-09t52zix 289 15 the the DT cord-007788-09t52zix 289 16 immunocompromised immunocompromised JJ cord-007788-09t52zix 289 17 host host NN cord-007788-09t52zix 289 18 can can MD cord-007788-09t52zix 289 19 be be VB cord-007788-09t52zix 289 20 viral viral JJ cord-007788-09t52zix 289 21 infection infection NN cord-007788-09t52zix 289 22 . . . cord-007788-09t52zix 290 1 Viral viral JJ cord-007788-09t52zix 290 2 particles particle NNS cord-007788-09t52zix 290 3 are be VBP cord-007788-09t52zix 290 4 frequently frequently RB cord-007788-09t52zix 290 5 identified identify VBN cord-007788-09t52zix 290 6 from from IN cord-007788-09t52zix 290 7 the the DT cord-007788-09t52zix 290 8 urine urine NN cord-007788-09t52zix 290 9 of of IN cord-007788-09t52zix 290 10 HSCT HSCT NNP cord-007788-09t52zix 290 11 recipients recipient NNS cord-007788-09t52zix 290 12 . . . cord-007788-09t52zix 291 1 Of of IN cord-007788-09t52zix 291 2 these these DT cord-007788-09t52zix 291 3 , , , cord-007788-09t52zix 291 4 reactivation reactivation NN cord-007788-09t52zix 291 5 of of IN cord-007788-09t52zix 291 6 the the DT cord-007788-09t52zix 291 7 polyoma polyoma NNP cord-007788-09t52zix 291 8 BK BK NNP cord-007788-09t52zix 291 9 virus virus NN cord-007788-09t52zix 291 10 ( ( -LRB- cord-007788-09t52zix 291 11 BKV BKV NNP cord-007788-09t52zix 291 12 ) ) -RRB- cord-007788-09t52zix 291 13 is be VBZ cord-007788-09t52zix 291 14 the the DT cord-007788-09t52zix 291 15 commonest common JJS cord-007788-09t52zix 291 16 and and CC cord-007788-09t52zix 291 17 most most RBS cord-007788-09t52zix 291 18 consistent consistent JJ cord-007788-09t52zix 291 19 risk risk NN cord-007788-09t52zix 291 20 factor factor NN cord-007788-09t52zix 291 21 for for IN cord-007788-09t52zix 291 22 HC HC NNP cord-007788-09t52zix 291 23 following follow VBG cord-007788-09t52zix 291 24 HSCT HSCT NNP cord-007788-09t52zix 291 25 , , , cord-007788-09t52zix 291 26 as as IN cord-007788-09t52zix 291 27 the the DT cord-007788-09t52zix 291 28 virus virus NN cord-007788-09t52zix 291 29 is be VBZ cord-007788-09t52zix 291 30 almost almost RB cord-007788-09t52zix 291 31 invariably invariably RB cord-007788-09t52zix 291 32 present present JJ cord-007788-09t52zix 291 33 in in IN cord-007788-09t52zix 291 34 the the DT cord-007788-09t52zix 291 35 urine urine NN cord-007788-09t52zix 291 36 of of IN cord-007788-09t52zix 291 37 patients patient NNS cord-007788-09t52zix 291 38 with with IN cord-007788-09t52zix 291 39 HC HC NNP cord-007788-09t52zix 291 40 ( ( -LRB- cord-007788-09t52zix 291 41 Leung Leung NNP cord-007788-09t52zix 291 42 et et NNP cord-007788-09t52zix 291 43 al al NNP cord-007788-09t52zix 291 44 . . NNP cord-007788-09t52zix 291 45 2005 2005 CD cord-007788-09t52zix 291 46 ) ) -RRB- cord-007788-09t52zix 291 47 . . . cord-007788-09t52zix 292 1 The the DT cord-007788-09t52zix 292 2 damaged damage VBN cord-007788-09t52zix 292 3 urothelial urothelial JJ cord-007788-09t52zix 292 4 cells cell NNS cord-007788-09t52zix 292 5 provide provide VBP cord-007788-09t52zix 292 6 a a DT cord-007788-09t52zix 292 7 milieu milieu NN cord-007788-09t52zix 292 8 for for IN cord-007788-09t52zix 292 9 viral viral JJ cord-007788-09t52zix 292 10 replication replication NN cord-007788-09t52zix 292 11 . . . cord-007788-09t52zix 293 1 Immunosuppression Immunosuppression NNP cord-007788-09t52zix 293 2 leads lead VBZ cord-007788-09t52zix 293 3 to to IN cord-007788-09t52zix 293 4 viral viral JJ cord-007788-09t52zix 293 5 reactivation reactivation NN cord-007788-09t52zix 293 6 and and CC cord-007788-09t52zix 293 7 causes cause NNS cord-007788-09t52zix 293 8 viruria viruria NNS cord-007788-09t52zix 293 9 . . . cord-007788-09t52zix 294 1 However however RB cord-007788-09t52zix 294 2 , , , cord-007788-09t52zix 294 3 the the DT cord-007788-09t52zix 294 4 exact exact JJ cord-007788-09t52zix 294 5 pathogenetic pathogenetic JJ cord-007788-09t52zix 294 6 link link NN cord-007788-09t52zix 294 7 between between IN cord-007788-09t52zix 294 8 BKV BKV NNP cord-007788-09t52zix 294 9 and and CC cord-007788-09t52zix 294 10 HC HC NNP cord-007788-09t52zix 294 11 remains remain VBZ cord-007788-09t52zix 294 12 enigmatic enigmatic JJ cord-007788-09t52zix 294 13 . . . cord-007788-09t52zix 295 1 Other other JJ cord-007788-09t52zix 295 2 viral viral JJ cord-007788-09t52zix 295 3 agents agent NNS cord-007788-09t52zix 295 4 such such JJ cord-007788-09t52zix 295 5 as as IN cord-007788-09t52zix 295 6 adenovirus adenovirus NN cord-007788-09t52zix 295 7 , , , cord-007788-09t52zix 295 8 cytomegalovirus cytomegalovirus NNP cord-007788-09t52zix 295 9 ( ( -LRB- cord-007788-09t52zix 295 10 CMV CMV NNP cord-007788-09t52zix 295 11 ) ) -RRB- cord-007788-09t52zix 295 12 and and CC cord-007788-09t52zix 295 13 other other JJ cord-007788-09t52zix 295 14 polyomaviruses polyomaviruse NNS cord-007788-09t52zix 295 15 similar similar JJ cord-007788-09t52zix 295 16 to to IN cord-007788-09t52zix 295 17 BKV BKV NNP cord-007788-09t52zix 295 18 may may MD cord-007788-09t52zix 295 19 also also RB cord-007788-09t52zix 295 20 but but CC cord-007788-09t52zix 295 21 less less RBR cord-007788-09t52zix 295 22 often often RB cord-007788-09t52zix 295 23 cause cause VB cord-007788-09t52zix 295 24 HC HC NNP cord-007788-09t52zix 295 25 . . . cord-007788-09t52zix 296 1 Alloimmunity Alloimmunity NNP cord-007788-09t52zix 296 2 after after IN cord-007788-09t52zix 296 3 engraftment engraftment NN cord-007788-09t52zix 296 4 by by IN cord-007788-09t52zix 296 5 attack attack NN cord-007788-09t52zix 296 6 from from IN cord-007788-09t52zix 296 7 donor donor NN cord-007788-09t52zix 296 8 lymphoid lymphoid NN cord-007788-09t52zix 296 9 cells cell NNS cord-007788-09t52zix 296 10 against against IN cord-007788-09t52zix 296 11 infected infected JJ cord-007788-09t52zix 296 12 urothelial urothelial JJ cord-007788-09t52zix 296 13 cells cell NNS cord-007788-09t52zix 296 14 has have VBZ cord-007788-09t52zix 296 15 not not RB cord-007788-09t52zix 296 16 been be VBN cord-007788-09t52zix 296 17 confirmed confirm VBN cord-007788-09t52zix 296 18 as as IN cord-007788-09t52zix 296 19 causing cause VBG cord-007788-09t52zix 296 20 HC HC NNP cord-007788-09t52zix 296 21 but but CC cord-007788-09t52zix 296 22 may may MD cord-007788-09t52zix 296 23 be be VB cord-007788-09t52zix 296 24 an an DT cord-007788-09t52zix 296 25 additional additional JJ cord-007788-09t52zix 296 26 potential potential JJ cord-007788-09t52zix 296 27 factor factor NN cord-007788-09t52zix 296 28 for for IN cord-007788-09t52zix 296 29 development development NN cord-007788-09t52zix 296 30 of of IN cord-007788-09t52zix 296 31 this this DT cord-007788-09t52zix 296 32 complication complication NN cord-007788-09t52zix 296 33 . . . cord-007788-09t52zix 297 1 The the DT cord-007788-09t52zix 297 2 diagnosis diagnosis NN cord-007788-09t52zix 297 3 of of IN cord-007788-09t52zix 297 4 HC HC NNP cord-007788-09t52zix 297 5 is be VBZ cord-007788-09t52zix 297 6 confirmed confirm VBN cord-007788-09t52zix 297 7 by by IN cord-007788-09t52zix 297 8 the the DT cord-007788-09t52zix 297 9 presence presence NN cord-007788-09t52zix 297 10 of of IN cord-007788-09t52zix 297 11 haematuria haematuria NNP cord-007788-09t52zix 297 12 and and CC cord-007788-09t52zix 297 13 symptoms symptom NNS cord-007788-09t52zix 297 14 of of IN cord-007788-09t52zix 297 15 cystitis cystitis NN cord-007788-09t52zix 297 16 taking take VBG cord-007788-09t52zix 297 17 into into IN cord-007788-09t52zix 297 18 account account NN cord-007788-09t52zix 297 19 risk risk NN cord-007788-09t52zix 297 20 factors factor NNS cord-007788-09t52zix 297 21 such such JJ cord-007788-09t52zix 297 22 as as IN cord-007788-09t52zix 297 23 : : : cord-007788-09t52zix 297 24 _SP cord-007788-09t52zix 298 1 In in IN cord-007788-09t52zix 298 2 most most JJS cord-007788-09t52zix 298 3 cases case NNS cord-007788-09t52zix 298 4 of of IN cord-007788-09t52zix 298 5 chemotherapy chemotherapy NN cord-007788-09t52zix 298 6 - - HYPH cord-007788-09t52zix 298 7 induced induce VBN cord-007788-09t52zix 298 8 HC HC NNP cord-007788-09t52zix 298 9 with with IN cord-007788-09t52zix 298 10 pre pre JJ cord-007788-09t52zix 298 11 - - JJ cord-007788-09t52zix 298 12 engraftment engraftment JJ cord-007788-09t52zix 298 13 onset onset NN cord-007788-09t52zix 298 14 and and CC cord-007788-09t52zix 298 15 in in IN cord-007788-09t52zix 298 16 polyomaviruria polyomaviruria NNP cord-007788-09t52zix 298 17 , , , cord-007788-09t52zix 298 18 the the DT cord-007788-09t52zix 298 19 condition condition NN cord-007788-09t52zix 298 20 is be VBZ cord-007788-09t52zix 298 21 self self NN cord-007788-09t52zix 298 22 - - HYPH cord-007788-09t52zix 298 23 limiting limit VBG cord-007788-09t52zix 298 24 and and CC cord-007788-09t52zix 298 25 the the DT cord-007788-09t52zix 298 26 prognosis prognosis NN cord-007788-09t52zix 298 27 is be VBZ cord-007788-09t52zix 298 28 good good JJ cord-007788-09t52zix 298 29 . . . cord-007788-09t52zix 299 1 If if IN cord-007788-09t52zix 299 2 the the DT cord-007788-09t52zix 299 3 viruria viruria NN cord-007788-09t52zix 299 4 is be VBZ cord-007788-09t52zix 299 5 caused cause VBN cord-007788-09t52zix 299 6 by by IN cord-007788-09t52zix 299 7 adenovirus adenovirus NN cord-007788-09t52zix 299 8 , , , cord-007788-09t52zix 299 9 the the DT cord-007788-09t52zix 299 10 prognosis prognosis NN cord-007788-09t52zix 299 11 is be VBZ cord-007788-09t52zix 299 12 worse bad JJR cord-007788-09t52zix 299 13 with with IN cord-007788-09t52zix 299 14 the the DT cord-007788-09t52zix 299 15 risk risk NN cord-007788-09t52zix 299 16 of of IN cord-007788-09t52zix 299 17 progression progression NN cord-007788-09t52zix 299 18 to to IN cord-007788-09t52zix 299 19 systemic systemic JJ cord-007788-09t52zix 299 20 adenovirus adenovirus NN cord-007788-09t52zix 299 21 infection infection NN cord-007788-09t52zix 299 22 . . . cord-007788-09t52zix 300 1 In in IN cord-007788-09t52zix 300 2 these these DT cord-007788-09t52zix 300 3 cases case NNS cord-007788-09t52zix 300 4 early early JJ cord-007788-09t52zix 300 5 pharmacological pharmacological JJ cord-007788-09t52zix 300 6 intervention intervention NN cord-007788-09t52zix 300 7 with with IN cord-007788-09t52zix 300 8 antiviral antiviral JJ cord-007788-09t52zix 300 9 drugs drug NNS cord-007788-09t52zix 300 10 , , , cord-007788-09t52zix 300 11 e.g. e.g. RB cord-007788-09t52zix 300 12 cidofovir cidofovir NNS cord-007788-09t52zix 300 13 , , , cord-007788-09t52zix 300 14 is be VBZ cord-007788-09t52zix 300 15 recommended recommend VBN cord-007788-09t52zix 300 16 . . . cord-007788-09t52zix 301 1 Hyperhydration Hyperhydration NNP cord-007788-09t52zix 301 2 with with IN cord-007788-09t52zix 301 3 forced force VBN cord-007788-09t52zix 301 4 diuresis diuresis NN cord-007788-09t52zix 301 5 , , , cord-007788-09t52zix 301 6 i.e. i.e. FW cord-007788-09t52zix 301 7 3 3 CD cord-007788-09t52zix 301 8 L/ L/ NNP cord-007788-09t52zix 301 9 m m CD cord-007788-09t52zix 301 10 2 2 CD cord-007788-09t52zix 302 1 /24 /24 NNP cord-007788-09t52zix 302 2 h h NNP cord-007788-09t52zix 302 3 with with IN cord-007788-09t52zix 302 4 the the DT cord-007788-09t52zix 302 5 goal goal NN cord-007788-09t52zix 302 6 of of IN cord-007788-09t52zix 302 7 a a DT cord-007788-09t52zix 302 8 diuresis diuresis NN cord-007788-09t52zix 302 9 of of IN cord-007788-09t52zix 302 10 > > $ cord-007788-09t52zix 302 11 250 250 CD cord-007788-09t52zix 302 12 mL ml NN cord-007788-09t52zix 302 13 / / SYM cord-007788-09t52zix 302 14 h h NN cord-007788-09t52zix 302 15 , , , cord-007788-09t52zix 302 16 during during IN cord-007788-09t52zix 302 17 and and CC cord-007788-09t52zix 302 18 until until IN cord-007788-09t52zix 302 19 the the DT cord-007788-09t52zix 302 20 day day NN cord-007788-09t52zix 302 21 after after IN cord-007788-09t52zix 302 22 administration administration NN cord-007788-09t52zix 302 23 of of IN cord-007788-09t52zix 302 24 an an DT cord-007788-09t52zix 302 25 alkylating alkylating JJ cord-007788-09t52zix 302 26 agent agent NN cord-007788-09t52zix 302 27 is be VBZ cord-007788-09t52zix 302 28 the the DT cord-007788-09t52zix 302 29 most most RBS cord-007788-09t52zix 302 30 important important JJ cord-007788-09t52zix 302 31 preventive preventive JJ cord-007788-09t52zix 302 32 action action NN cord-007788-09t52zix 302 33 . . . cord-007788-09t52zix 303 1 If if IN cord-007788-09t52zix 303 2 the the DT cord-007788-09t52zix 303 3 diuresis diuresis NN cord-007788-09t52zix 303 4 is be VBZ cord-007788-09t52zix 303 5 insufficient insufficient JJ cord-007788-09t52zix 303 6 , , , cord-007788-09t52zix 303 7 diuretics diuretic NNS cord-007788-09t52zix 303 8 should should MD cord-007788-09t52zix 303 9 be be VB cord-007788-09t52zix 303 10 administered administer VBN cord-007788-09t52zix 303 11 . . . cord-007788-09t52zix 304 1 The the DT cord-007788-09t52zix 304 2 forced force VBN cord-007788-09t52zix 304 3 diuresis diuresis NN cord-007788-09t52zix 304 4 will will MD cord-007788-09t52zix 304 5 not not RB cord-007788-09t52zix 304 6 just just RB cord-007788-09t52zix 304 7 dilute dilute VB cord-007788-09t52zix 304 8 the the DT cord-007788-09t52zix 304 9 urine urine NN cord-007788-09t52zix 304 10 but but CC cord-007788-09t52zix 304 11 shorten shorten VB cord-007788-09t52zix 304 12 the the DT cord-007788-09t52zix 304 13 time time NN cord-007788-09t52zix 304 14 of of IN cord-007788-09t52zix 304 15 duration duration NN cord-007788-09t52zix 304 16 for for IN cord-007788-09t52zix 304 17 acrolein acrolein NN cord-007788-09t52zix 304 18 exposure exposure NN cord-007788-09t52zix 304 19 to to IN cord-007788-09t52zix 304 20 the the DT cord-007788-09t52zix 304 21 bladder bladder NN cord-007788-09t52zix 304 22 and and CC cord-007788-09t52zix 304 23 thus thus RB cord-007788-09t52zix 304 24 prevent prevent VB cord-007788-09t52zix 304 25 the the DT cord-007788-09t52zix 304 26 toxic toxic JJ cord-007788-09t52zix 304 27 effects effect NNS cord-007788-09t52zix 304 28 . . . cord-007788-09t52zix 305 1 During during IN cord-007788-09t52zix 305 2 the the DT cord-007788-09t52zix 305 3 days day NNS cord-007788-09t52zix 305 4 of of IN cord-007788-09t52zix 305 5 hyperhydration hyperhydration NN cord-007788-09t52zix 305 6 , , , cord-007788-09t52zix 305 7 the the DT cord-007788-09t52zix 305 8 patient patient NN cord-007788-09t52zix 305 9 shall shall MD cord-007788-09t52zix 305 10 be be VB cord-007788-09t52zix 305 11 closely closely RB cord-007788-09t52zix 305 12 monitored monitor VBN cord-007788-09t52zix 305 13 for for IN cord-007788-09t52zix 305 14 fluid fluid JJ cord-007788-09t52zix 305 15 balance balance NN cord-007788-09t52zix 305 16 , , , cord-007788-09t52zix 305 17 including include VBG cord-007788-09t52zix 305 18 weight weight NN cord-007788-09t52zix 305 19 , , , cord-007788-09t52zix 305 20 at at IN cord-007788-09t52zix 305 21 regular regular JJ cord-007788-09t52zix 305 22 intervals interval NNS cord-007788-09t52zix 305 23 . . . cord-007788-09t52zix 306 1 An an DT cord-007788-09t52zix 306 2 electrocardiogram electrocardiogram NN cord-007788-09t52zix 306 3 ( ( -LRB- cord-007788-09t52zix 306 4 ECG ECG NNP cord-007788-09t52zix 306 5 ) ) -RRB- cord-007788-09t52zix 306 6 should should MD cord-007788-09t52zix 306 7 be be VB cord-007788-09t52zix 306 8 taken take VBN cord-007788-09t52zix 306 9 , , , cord-007788-09t52zix 306 10 and and CC cord-007788-09t52zix 306 11 approved approve VBD cord-007788-09t52zix 306 12 , , , cord-007788-09t52zix 306 13 prior prior RB cord-007788-09t52zix 306 14 to to IN cord-007788-09t52zix 306 15 start start NN cord-007788-09t52zix 306 16 of of IN cord-007788-09t52zix 306 17 treatment treatment NN cord-007788-09t52zix 306 18 , , , cord-007788-09t52zix 306 19 and and CC cord-007788-09t52zix 306 20 vital vital JJ cord-007788-09t52zix 306 21 signs sign NNS cord-007788-09t52zix 306 22 ( ( -LRB- cord-007788-09t52zix 306 23 blood blood NN cord-007788-09t52zix 306 24 pressure pressure NN cord-007788-09t52zix 306 25 , , , cord-007788-09t52zix 306 26 pulse pulse NN cord-007788-09t52zix 306 27 , , , cord-007788-09t52zix 306 28 oxygen oxygen NN cord-007788-09t52zix 306 29 saturation saturation NN cord-007788-09t52zix 306 30 and and CC cord-007788-09t52zix 306 31 respiratory respiratory JJ cord-007788-09t52zix 306 32 rate rate NN cord-007788-09t52zix 306 33 ) ) -RRB- cord-007788-09t52zix 306 34 should should MD cord-007788-09t52zix 306 35 be be VB cord-007788-09t52zix 306 36 checked check VBN cord-007788-09t52zix 306 37 throughout throughout IN cord-007788-09t52zix 306 38 the the DT cord-007788-09t52zix 306 39 day day NN cord-007788-09t52zix 306 40 in in IN cord-007788-09t52zix 306 41 order order NN cord-007788-09t52zix 306 42 to to TO cord-007788-09t52zix 306 43 ascertain ascertain VB cord-007788-09t52zix 306 44 circulatory circulatory JJ cord-007788-09t52zix 306 45 stability stability NN cord-007788-09t52zix 306 46 . . . cord-007788-09t52zix 307 1 Electrolytes electrolyte NNS cord-007788-09t52zix 307 2 and and CC cord-007788-09t52zix 307 3 renal renal JJ cord-007788-09t52zix 307 4 function function NN cord-007788-09t52zix 307 5 should should MD cord-007788-09t52zix 307 6 be be VB cord-007788-09t52zix 307 7 monitored monitor VBN cord-007788-09t52zix 307 8 by by IN cord-007788-09t52zix 307 9 blood blood NN cord-007788-09t52zix 307 10 samples sample NNS cord-007788-09t52zix 307 11 and and CC cord-007788-09t52zix 307 12 electrolyte electrolyte JJ cord-007788-09t52zix 307 13 substitution substitution NN cord-007788-09t52zix 307 14 given give VBN cord-007788-09t52zix 307 15 where where WRB cord-007788-09t52zix 307 16 required require VBN cord-007788-09t52zix 307 17 . . . cord-007788-09t52zix 308 1 A a DT cord-007788-09t52zix 308 2 need need NN cord-007788-09t52zix 308 3 for for IN cord-007788-09t52zix 308 4 potassium potassium NN cord-007788-09t52zix 308 5 substitution substitution NN cord-007788-09t52zix 308 6 is be VBZ cord-007788-09t52zix 308 7 not not RB cord-007788-09t52zix 308 8 uncommon uncommon JJ cord-007788-09t52zix 308 9 . . . cord-007788-09t52zix 309 1 The the DT cord-007788-09t52zix 309 2 patient patient NN cord-007788-09t52zix 309 3 should should MD cord-007788-09t52zix 309 4 also also RB cord-007788-09t52zix 309 5 be be VB cord-007788-09t52zix 309 6 assessed assess VBN cord-007788-09t52zix 309 7 for for IN cord-007788-09t52zix 309 8 any any DT cord-007788-09t52zix 309 9 urinary urinary JJ cord-007788-09t52zix 309 10 or or CC cord-007788-09t52zix 309 11 low low JJ cord-007788-09t52zix 309 12 abdominal abdominal JJ cord-007788-09t52zix 309 13 pain pain NN cord-007788-09t52zix 309 14 or or CC cord-007788-09t52zix 309 15 discom discom NN cord-007788-09t52zix 309 16 - - HYPH cord-007788-09t52zix 309 17 fort fort NNP cord-007788-09t52zix 309 18 . . . cord-007788-09t52zix 310 1 All all DT cord-007788-09t52zix 310 2 assessments assessment NNS cord-007788-09t52zix 310 3 mentioned mention VBN cord-007788-09t52zix 310 4 above above RB cord-007788-09t52zix 310 5 should should MD cord-007788-09t52zix 310 6 be be VB cord-007788-09t52zix 310 7 performed perform VBN cord-007788-09t52zix 310 8 at at IN cord-007788-09t52zix 310 9 least least JJS cord-007788-09t52zix 310 10 every every DT cord-007788-09t52zix 310 11 6 6 CD cord-007788-09t52zix 310 12 h. h. NN cord-007788-09t52zix 311 1 Informing inform VBG cord-007788-09t52zix 311 2 the the DT cord-007788-09t52zix 311 3 patient patient NN cord-007788-09t52zix 311 4 about about IN cord-007788-09t52zix 311 5 the the DT cord-007788-09t52zix 311 6 treatment treatment NN cord-007788-09t52zix 311 7 and and CC cord-007788-09t52zix 311 8 treatment treatment NN cord-007788-09t52zix 311 9 goals goal NNS cord-007788-09t52zix 311 10 as as RB cord-007788-09t52zix 311 11 well well RB cord-007788-09t52zix 311 12 as as IN cord-007788-09t52zix 311 13 the the DT cord-007788-09t52zix 311 14 importance importance NN cord-007788-09t52zix 311 15 of of IN cord-007788-09t52zix 311 16 reporting report VBG cord-007788-09t52zix 311 17 any any DT cord-007788-09t52zix 311 18 symptoms symptom NNS cord-007788-09t52zix 311 19 of of IN cord-007788-09t52zix 311 20 HC HC NNP cord-007788-09t52zix 311 21 will will MD cord-007788-09t52zix 311 22 help help VB cord-007788-09t52zix 311 23 ensure ensure VB cord-007788-09t52zix 311 24 that that IN cord-007788-09t52zix 311 25 appropriate appropriate JJ cord-007788-09t52zix 311 26 actions action NNS cord-007788-09t52zix 311 27 and and CC cord-007788-09t52zix 311 28 early early JJ cord-007788-09t52zix 311 29 intervention intervention NN cord-007788-09t52zix 311 30 can can MD cord-007788-09t52zix 311 31 be be VB cord-007788-09t52zix 311 32 applied apply VBN cord-007788-09t52zix 311 33 without without IN cord-007788-09t52zix 311 34 delay delay NN cord-007788-09t52zix 311 35 . . . cord-007788-09t52zix 312 1 For for IN cord-007788-09t52zix 312 2 patients patient NNS cord-007788-09t52zix 312 3 receiving receive VBG cord-007788-09t52zix 312 4 cyclophosphamideor cyclophosphamideor JJ cord-007788-09t52zix 312 5 ifosfamide ifosfamide NNP cord-007788-09t52zix 312 6 - - HYPH cord-007788-09t52zix 312 7 based base VBN cord-007788-09t52zix 312 8 regimens regimen NNS cord-007788-09t52zix 312 9 , , , cord-007788-09t52zix 312 10 the the DT cord-007788-09t52zix 312 11 drug drug NN cord-007788-09t52zix 312 12 mesna mesna NNS cord-007788-09t52zix 312 13 ( ( -LRB- cord-007788-09t52zix 312 14 sodium sodium NN cord-007788-09t52zix 312 15 2-mercaptoethanesulfonate 2-mercaptoethanesulfonate CD cord-007788-09t52zix 312 16 ) ) -RRB- cord-007788-09t52zix 312 17 can can MD cord-007788-09t52zix 312 18 be be VB cord-007788-09t52zix 312 19 used use VBN cord-007788-09t52zix 312 20 as as IN cord-007788-09t52zix 312 21 pharmacological pharmacological JJ cord-007788-09t52zix 312 22 prophylaxis prophylaxis NN cord-007788-09t52zix 312 23 , , , cord-007788-09t52zix 312 24 although although IN cord-007788-09t52zix 312 25 the the DT cord-007788-09t52zix 312 26 additional additional JJ cord-007788-09t52zix 312 27 benefit benefit NN cord-007788-09t52zix 312 28 in in IN cord-007788-09t52zix 312 29 the the DT cord-007788-09t52zix 312 30 HSCT HSCT NNP cord-007788-09t52zix 312 31 setting setting NN cord-007788-09t52zix 312 32 has have VBZ cord-007788-09t52zix 312 33 not not RB cord-007788-09t52zix 312 34 been be VBN cord-007788-09t52zix 312 35 scientifically scientifically RB cord-007788-09t52zix 312 36 proven prove VBN cord-007788-09t52zix 312 37 in in IN cord-007788-09t52zix 312 38 comparison comparison NN cord-007788-09t52zix 312 39 with with IN cord-007788-09t52zix 312 40 hyperhydration hyperhydration NN cord-007788-09t52zix 312 41 and and CC cord-007788-09t52zix 312 42 forced force VBN cord-007788-09t52zix 312 43 diuresis diuresis NN cord-007788-09t52zix 312 44 . . . cord-007788-09t52zix 313 1 Mesna Mesna NNS cord-007788-09t52zix 313 2 binds bind VBZ cord-007788-09t52zix 313 3 to to IN cord-007788-09t52zix 313 4 the the DT cord-007788-09t52zix 313 5 toxic toxic JJ cord-007788-09t52zix 313 6 metabolite metabolite NN cord-007788-09t52zix 313 7 acrolein acrolein NN cord-007788-09t52zix 313 8 and and CC cord-007788-09t52zix 313 9 forms form VBZ cord-007788-09t52zix 313 10 a a DT cord-007788-09t52zix 313 11 non non JJ cord-007788-09t52zix 313 12 - - JJ cord-007788-09t52zix 313 13 toxic toxic JJ cord-007788-09t52zix 313 14 compound compound NN cord-007788-09t52zix 313 15 . . . cord-007788-09t52zix 314 1 By by IN cord-007788-09t52zix 314 2 additional additional JJ cord-007788-09t52zix 314 3 actions action NNS cord-007788-09t52zix 314 4 mesna mesna NNS cord-007788-09t52zix 314 5 also also RB cord-007788-09t52zix 314 6 reduces reduce VBZ cord-007788-09t52zix 314 7 the the DT cord-007788-09t52zix 314 8 forming forming NN cord-007788-09t52zix 314 9 of of IN cord-007788-09t52zix 314 10 acrolein acrolein NN cord-007788-09t52zix 314 11 in in IN cord-007788-09t52zix 314 12 the the DT cord-007788-09t52zix 314 13 urine urine NN cord-007788-09t52zix 314 14 . . . cord-007788-09t52zix 315 1 The the DT cord-007788-09t52zix 315 2 drug drug NN cord-007788-09t52zix 315 3 itself -PRON- PRP cord-007788-09t52zix 315 4 has have VBZ cord-007788-09t52zix 315 5 low low JJ cord-007788-09t52zix 315 6 toxicity toxicity NN cord-007788-09t52zix 315 7 ( ( -LRB- cord-007788-09t52zix 315 8 Mesna Mesna NNP cord-007788-09t52zix 315 9 Summary Summary NNP cord-007788-09t52zix 315 10 of of IN cord-007788-09t52zix 315 11 Product Product NNP cord-007788-09t52zix 315 12 Characteristics characteristic NNS cord-007788-09t52zix 315 13 2017 2017 CD cord-007788-09t52zix 316 1 ( ( -LRB- cord-007788-09t52zix 316 2 SPC SPC NNP cord-007788-09t52zix 316 3 ) ) -RRB- cord-007788-09t52zix 317 1 [ [ -LRB- cord-007788-09t52zix 317 2 in in IN cord-007788-09t52zix 317 3 Swedish Swedish NNP cord-007788-09t52zix 317 4 ] ] -RRB- cord-007788-09t52zix 317 5 ) ) -RRB- cord-007788-09t52zix 317 6 . . . cord-007788-09t52zix 318 1 In in IN cord-007788-09t52zix 318 2 HSCT HSCT NNP cord-007788-09t52zix 318 3 conditioning conditioning NN cord-007788-09t52zix 318 4 with with IN cord-007788-09t52zix 318 5 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 318 6 , , , cord-007788-09t52zix 318 7 the the DT cord-007788-09t52zix 318 8 recommended recommend VBN cord-007788-09t52zix 318 9 dose dose NN cord-007788-09t52zix 318 10 of of IN cord-007788-09t52zix 318 11 mesna mesna NNS cord-007788-09t52zix 318 12 according accord VBG cord-007788-09t52zix 318 13 to to IN cord-007788-09t52zix 318 14 the the DT cord-007788-09t52zix 318 15 Summary Summary NNP cord-007788-09t52zix 318 16 of of IN cord-007788-09t52zix 318 17 Product Product NNP cord-007788-09t52zix 318 18 Characteristics Characteristics NNP cord-007788-09t52zix 318 19 ( ( -LRB- cord-007788-09t52zix 318 20 SPC SPC NNP cord-007788-09t52zix 318 21 ) ) -RRB- cord-007788-09t52zix 318 22 is be VBZ cord-007788-09t52zix 318 23 20 20 CD cord-007788-09t52zix 318 24 % % NN cord-007788-09t52zix 318 25 of of IN cord-007788-09t52zix 318 26 the the DT cord-007788-09t52zix 318 27 cyclophosphamide cyclophosphamide JJ cord-007788-09t52zix 318 28 dose dose NN cord-007788-09t52zix 318 29 and and CC cord-007788-09t52zix 318 30 the the DT cord-007788-09t52zix 318 31 first first JJ cord-007788-09t52zix 318 32 mesna mesna NNS cord-007788-09t52zix 318 33 dose dose NN cord-007788-09t52zix 318 34 should should MD cord-007788-09t52zix 318 35 be be VB cord-007788-09t52zix 318 36 administered administer VBN cord-007788-09t52zix 318 37 immediately immediately RB cord-007788-09t52zix 318 38 prior prior RB cord-007788-09t52zix 318 39 to to IN cord-007788-09t52zix 318 40 the the DT cord-007788-09t52zix 318 41 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 318 42 . . . cord-007788-09t52zix 319 1 Subsequent subsequent JJ cord-007788-09t52zix 319 2 doses dose NNS cord-007788-09t52zix 319 3 will will MD cord-007788-09t52zix 319 4 then then RB cord-007788-09t52zix 319 5 be be VB cord-007788-09t52zix 319 6 given give VBN cord-007788-09t52zix 319 7 at at IN cord-007788-09t52zix 319 8 3 3 CD cord-007788-09t52zix 319 9 , , , cord-007788-09t52zix 319 10 6 6 CD cord-007788-09t52zix 319 11 , , , cord-007788-09t52zix 319 12 9 9 CD cord-007788-09t52zix 319 13 and and CC cord-007788-09t52zix 319 14 12 12 CD cord-007788-09t52zix 319 15 h h NN cord-007788-09t52zix 319 16 after after IN cord-007788-09t52zix 319 17 administration administration NN cord-007788-09t52zix 319 18 of of IN cord-007788-09t52zix 319 19 cyclophosphamide cyclophosphamide NNP cord-007788-09t52zix 319 20 ( ( -LRB- cord-007788-09t52zix 319 21 totalling total VBG cord-007788-09t52zix 319 22 120 120 CD cord-007788-09t52zix 319 23 % % NN cord-007788-09t52zix 319 24 of of IN cord-007788-09t52zix 319 25 the the DT cord-007788-09t52zix 319 26 cyclophosphamide cyclophosphamide JJ cord-007788-09t52zix 319 27 dose dose NN cord-007788-09t52zix 319 28 ) ) -RRB- cord-007788-09t52zix 319 29 . . . cord-007788-09t52zix 320 1 It -PRON- PRP cord-007788-09t52zix 320 2 is be VBZ cord-007788-09t52zix 320 3 important important JJ cord-007788-09t52zix 320 4 to to TO cord-007788-09t52zix 320 5 adhere adhere VB cord-007788-09t52zix 320 6 to to IN cord-007788-09t52zix 320 7 the the DT cord-007788-09t52zix 320 8 timing timing NN cord-007788-09t52zix 320 9 of of IN cord-007788-09t52zix 320 10 mesna mesna NNS cord-007788-09t52zix 320 11 doses dose NNS cord-007788-09t52zix 320 12 in in IN cord-007788-09t52zix 320 13 order order NN cord-007788-09t52zix 320 14 to to TO cord-007788-09t52zix 320 15 ensure ensure VB cord-007788-09t52zix 320 16 efficacy efficacy NN cord-007788-09t52zix 320 17 of of IN cord-007788-09t52zix 320 18 the the DT cord-007788-09t52zix 320 19 treatment treatment NN cord-007788-09t52zix 320 20 . . . cord-007788-09t52zix 321 1 Mesna Mesna NNS cord-007788-09t52zix 321 2 treatment treatment NN cord-007788-09t52zix 321 3 should should MD cord-007788-09t52zix 321 4 be be VB cord-007788-09t52zix 321 5 continued continue VBN cord-007788-09t52zix 321 6 during during IN cord-007788-09t52zix 321 7 the the DT cord-007788-09t52zix 321 8 cyclophosphamide cyclophosphamide JJ cord-007788-09t52zix 321 9 treatment treatment NN cord-007788-09t52zix 321 10 period period NN cord-007788-09t52zix 321 11 plus plus CC cord-007788-09t52zix 321 12 the the DT cord-007788-09t52zix 321 13 time time NN cord-007788-09t52zix 321 14 predicted predict VBD cord-007788-09t52zix 321 15 for for IN cord-007788-09t52zix 321 16 the the DT cord-007788-09t52zix 321 17 metabolites metabolite NNS cord-007788-09t52zix 321 18 to to TO cord-007788-09t52zix 321 19 reach reach VB cord-007788-09t52zix 321 20 non non JJ cord-007788-09t52zix 321 21 - - JJ cord-007788-09t52zix 321 22 toxic toxic JJ cord-007788-09t52zix 321 23 levels level NNS cord-007788-09t52zix 321 24 . . . cord-007788-09t52zix 322 1 This this DT cord-007788-09t52zix 322 2 will will MD cord-007788-09t52zix 322 3 usually usually RB cord-007788-09t52zix 322 4 occur occur VB cord-007788-09t52zix 322 5 between between IN cord-007788-09t52zix 322 6 8 8 CD cord-007788-09t52zix 322 7 and and CC cord-007788-09t52zix 322 8 12 12 CD cord-007788-09t52zix 322 9 h h NN cord-007788-09t52zix 322 10 after after IN cord-007788-09t52zix 322 11 completed complete VBN cord-007788-09t52zix 322 12 cyclophosphamide cyclophosphamide NNP cord-007788-09t52zix 322 13 administration administration NN cord-007788-09t52zix 322 14 . . . cord-007788-09t52zix 323 1 This this DT cord-007788-09t52zix 323 2 treatment treatment NN cord-007788-09t52zix 323 3 schedule schedule NN cord-007788-09t52zix 323 4 for for IN cord-007788-09t52zix 323 5 mesna mesna NNS cord-007788-09t52zix 323 6 may may MD cord-007788-09t52zix 323 7 however however RB cord-007788-09t52zix 323 8 vary vary VB cord-007788-09t52zix 323 9 according accord VBG cord-007788-09t52zix 323 10 to to IN cord-007788-09t52zix 323 11 conditioning conditioning NN cord-007788-09t52zix 323 12 regimen regimen NN cord-007788-09t52zix 323 13 and and CC cord-007788-09t52zix 323 14 doses dose NNS cord-007788-09t52zix 323 15 as as RB cord-007788-09t52zix 323 16 well well RB cord-007788-09t52zix 323 17 as as IN cord-007788-09t52zix 323 18 to to TO cord-007788-09t52zix 323 19 patient patient VB cord-007788-09t52zix 323 20 individual individual JJ cord-007788-09t52zix 323 21 factors factor NNS cord-007788-09t52zix 323 22 . . . cord-007788-09t52zix 324 1 An an DT cord-007788-09t52zix 324 2 example example NN cord-007788-09t52zix 324 3 of of IN cord-007788-09t52zix 324 4 a a DT cord-007788-09t52zix 324 5 checklist checklist NN cord-007788-09t52zix 324 6 to to TO cord-007788-09t52zix 324 7 be be VB cord-007788-09t52zix 324 8 used use VBN cord-007788-09t52zix 324 9 during during IN cord-007788-09t52zix 324 10 high high JJ cord-007788-09t52zix 324 11 - - HYPH cord-007788-09t52zix 324 12 dose dose NN cord-007788-09t52zix 324 13 cyclophosphamide cyclophosphamide JJ cord-007788-09t52zix 324 14 treatment treatment NN cord-007788-09t52zix 324 15 is be VBZ cord-007788-09t52zix 324 16 enclosed enclose VBN cord-007788-09t52zix 324 17 . . . cord-007788-09t52zix 325 1 BK BK NNP cord-007788-09t52zix 325 2 virus virus NN cord-007788-09t52zix 325 3 - - HYPH cord-007788-09t52zix 325 4 induced induce VBN cord-007788-09t52zix 325 5 HC HC NNP cord-007788-09t52zix 325 6 may may MD cord-007788-09t52zix 325 7 be be VB cord-007788-09t52zix 325 8 prevented prevent VBN cord-007788-09t52zix 325 9 by by IN cord-007788-09t52zix 325 10 the the DT cord-007788-09t52zix 325 11 administration administration NN cord-007788-09t52zix 325 12 of of IN cord-007788-09t52zix 325 13 quinolones quinolones NNP cord-007788-09t52zix 325 14 ( ( -LRB- cord-007788-09t52zix 325 15 e.g. e.g. IN cord-007788-09t52zix 325 16 ciprofloxacin ciprofloxacin NNP cord-007788-09t52zix 325 17 ) ) -RRB- cord-007788-09t52zix 326 1 ( ( -LRB- cord-007788-09t52zix 326 2 Dropulic Dropulic NNP cord-007788-09t52zix 326 3 and and CC cord-007788-09t52zix 326 4 Jones Jones NNP cord-007788-09t52zix 326 5 2008 2008 CD cord-007788-09t52zix 326 6 ) ) -RRB- cord-007788-09t52zix 326 7 . . . cord-007788-09t52zix 327 1 Although although IN cord-007788-09t52zix 327 2 quinolones quinolone NNS cord-007788-09t52zix 327 3 are be VBP cord-007788-09t52zix 327 4 not not RB cord-007788-09t52zix 327 5 strictly strictly RB cord-007788-09t52zix 327 6 antiviral antiviral JJ cord-007788-09t52zix 327 7 , , , cord-007788-09t52zix 327 8 fluoroqui fluoroqui NNP cord-007788-09t52zix 327 9 nolones nolones NNPS cord-007788-09t52zix 327 10 are be VBP cord-007788-09t52zix 327 11 capable capable JJ cord-007788-09t52zix 327 12 of of IN cord-007788-09t52zix 327 13 inhibiting inhibit VBG cord-007788-09t52zix 327 14 the the DT cord-007788-09t52zix 327 15 helicase helicase NN cord-007788-09t52zix 327 16 activity activity NN cord-007788-09t52zix 327 17 of of IN cord-007788-09t52zix 327 18 BKV BKV NNP cord-007788-09t52zix 327 19 large large JJ cord-007788-09t52zix 327 20 T t NN cord-007788-09t52zix 327 21 antigen antigen NN cord-007788-09t52zix 327 22 ( ( -LRB- cord-007788-09t52zix 327 23 TAg TAg NNP cord-007788-09t52zix 327 24 ) ) -RRB- cord-007788-09t52zix 327 25 protein protein NN cord-007788-09t52zix 327 26 , , , cord-007788-09t52zix 327 27 which which WDT cord-007788-09t52zix 327 28 seems seem VBZ cord-007788-09t52zix 327 29 to to TO cord-007788-09t52zix 327 30 be be VB cord-007788-09t52zix 327 31 crucial crucial JJ cord-007788-09t52zix 327 32 for for IN cord-007788-09t52zix 327 33 separation separation NN cord-007788-09t52zix 327 34 of of IN cord-007788-09t52zix 327 35 the the DT cord-007788-09t52zix 327 36 double double RB cord-007788-09t52zix 327 37 - - HYPH cord-007788-09t52zix 327 38 stranded strand VBN cord-007788-09t52zix 327 39 DNA dna NN cord-007788-09t52zix 327 40 genome genome NN cord-007788-09t52zix 327 41 during during IN cord-007788-09t52zix 327 42 replication replication NN cord-007788-09t52zix 327 43 of of IN cord-007788-09t52zix 327 44 the the DT cord-007788-09t52zix 327 45 virus virus NN cord-007788-09t52zix 328 1 ( ( -LRB- cord-007788-09t52zix 328 2 Umbro Umbro NNP cord-007788-09t52zix 328 3 et et NNP cord-007788-09t52zix 328 4 al al NNP cord-007788-09t52zix 328 5 . . NNP cord-007788-09t52zix 328 6 2013 2013 CD cord-007788-09t52zix 328 7 ) ) -RRB- cord-007788-09t52zix 328 8 . . . cord-007788-09t52zix 329 1 There there EX cord-007788-09t52zix 329 2 is be VBZ cord-007788-09t52zix 329 3 currently currently RB cord-007788-09t52zix 329 4 no no DT cord-007788-09t52zix 329 5 consensus consensus NN cord-007788-09t52zix 329 6 regarding regard VBG cord-007788-09t52zix 329 7 this this DT cord-007788-09t52zix 329 8 prophylaxis prophylaxis NN cord-007788-09t52zix 329 9 because because IN cord-007788-09t52zix 329 10 many many JJ cord-007788-09t52zix 329 11 patients patient NNS cord-007788-09t52zix 329 12 with with IN cord-007788-09t52zix 329 13 BKV BKV NNP cord-007788-09t52zix 329 14 do do VBP cord-007788-09t52zix 329 15 not not RB cord-007788-09t52zix 329 16 develop develop VB cord-007788-09t52zix 329 17 HC HC NNP cord-007788-09t52zix 329 18 . . . cord-007788-09t52zix 330 1 The the DT cord-007788-09t52zix 330 2 fact fact NN cord-007788-09t52zix 330 3 that that IN cord-007788-09t52zix 330 4 there there EX cord-007788-09t52zix 330 5 is be VBZ cord-007788-09t52zix 330 6 a a DT cord-007788-09t52zix 330 7 general general JJ cord-007788-09t52zix 330 8 increase increase NN cord-007788-09t52zix 330 9 of of IN cord-007788-09t52zix 330 10 multidrug multidrug NN cord-007788-09t52zix 330 11 - - HYPH cord-007788-09t52zix 330 12 resistant resistant JJ cord-007788-09t52zix 330 13 microorganisms microorganism NNS cord-007788-09t52zix 330 14 makes make VBZ cord-007788-09t52zix 330 15 the the DT cord-007788-09t52zix 330 16 use use NN cord-007788-09t52zix 330 17 of of IN cord-007788-09t52zix 330 18 this this DT cord-007788-09t52zix 330 19 prophylaxis prophylaxis NN cord-007788-09t52zix 330 20 a a DT cord-007788-09t52zix 330 21 matter matter NN cord-007788-09t52zix 330 22 for for IN cord-007788-09t52zix 330 23 careful careful JJ cord-007788-09t52zix 330 24 consideration consideration NN cord-007788-09t52zix 330 25 . . . cord-007788-09t52zix 331 1 The the DT cord-007788-09t52zix 331 2 first first JJ cord-007788-09t52zix 331 3 intervention intervention NN cord-007788-09t52zix 331 4 will will MD cord-007788-09t52zix 331 5 be be VB cord-007788-09t52zix 331 6 hyperhydration hyperhydration NN cord-007788-09t52zix 331 7 with with IN cord-007788-09t52zix 331 8 forced force VBN cord-007788-09t52zix 331 9 diuresis diuresis NN cord-007788-09t52zix 331 10 to to TO cord-007788-09t52zix 331 11 prevent prevent VB cord-007788-09t52zix 331 12 clot clot NN cord-007788-09t52zix 331 13 formation formation NN cord-007788-09t52zix 331 14 . . . cord-007788-09t52zix 332 1 HC HC NNP cord-007788-09t52zix 332 2 is be VBZ cord-007788-09t52zix 332 3 usually usually RB cord-007788-09t52zix 332 4 painful painful JJ cord-007788-09t52zix 332 5 and and CC cord-007788-09t52zix 332 6 analgesia analgesia NN cord-007788-09t52zix 332 7 should should MD cord-007788-09t52zix 332 8 be be VB cord-007788-09t52zix 332 9 administered administer VBN cord-007788-09t52zix 332 10 . . . cord-007788-09t52zix 333 1 If if IN cord-007788-09t52zix 333 2 the the DT cord-007788-09t52zix 333 3 patient patient NN cord-007788-09t52zix 333 4 is be VBZ cord-007788-09t52zix 333 5 thrombocytopenic thrombocytopenic JJ cord-007788-09t52zix 333 6 , , , cord-007788-09t52zix 333 7 a a DT cord-007788-09t52zix 333 8 higher high JJR cord-007788-09t52zix 333 9 threshold threshold NN cord-007788-09t52zix 333 10 level level NN cord-007788-09t52zix 333 11 for for IN cord-007788-09t52zix 333 12 platelet platelet NN cord-007788-09t52zix 333 13 transfusion transfusion NN cord-007788-09t52zix 333 14 and and CC cord-007788-09t52zix 333 15 intensive intensive JJ cord-007788-09t52zix 333 16 platelet platelet NN cord-007788-09t52zix 333 17 support support NN cord-007788-09t52zix 333 18 should should MD cord-007788-09t52zix 333 19 be be VB cord-007788-09t52zix 333 20 applied apply VBN cord-007788-09t52zix 333 21 , , , cord-007788-09t52zix 333 22 in in IN cord-007788-09t52zix 333 23 particular particular JJ cord-007788-09t52zix 333 24 in in IN cord-007788-09t52zix 333 25 haematuria haematuria NNP cord-007788-09t52zix 333 26 grades grade NNS cord-007788-09t52zix 333 27 III III NNP cord-007788-09t52zix 333 28 - - HYPH cord-007788-09t52zix 333 29 IV IV NNP cord-007788-09t52zix 333 30 . . . cord-007788-09t52zix 334 1 Catheterisation catheterisation NN cord-007788-09t52zix 334 2 and and CC cord-007788-09t52zix 334 3 bladder bladder NN cord-007788-09t52zix 334 4 irrigation irrigation NN cord-007788-09t52zix 334 5 with with IN cord-007788-09t52zix 334 6 0.9 0.9 CD cord-007788-09t52zix 334 7 % % NN cord-007788-09t52zix 334 8 sodium sodium NN cord-007788-09t52zix 334 9 chloride chloride NN cord-007788-09t52zix 334 10 ( ( -LRB- cord-007788-09t52zix 334 11 normal normal JJ cord-007788-09t52zix 334 12 saline saline NN cord-007788-09t52zix 334 13 ) ) -RRB- cord-007788-09t52zix 334 14 may may MD cord-007788-09t52zix 334 15 be be VB cord-007788-09t52zix 334 16 necessary necessary JJ cord-007788-09t52zix 334 17 to to TO cord-007788-09t52zix 334 18 prevent prevent VB cord-007788-09t52zix 334 19 clot clot NN cord-007788-09t52zix 334 20 obstruction obstruction NN cord-007788-09t52zix 334 21 . . . cord-007788-09t52zix 335 1 Catheter catheter NN cord-007788-09t52zix 335 2 insertion insertion NN cord-007788-09t52zix 335 3 should should MD cord-007788-09t52zix 335 4 be be VB cord-007788-09t52zix 335 5 performed perform VBN cord-007788-09t52zix 335 6 so so IN cord-007788-09t52zix 335 7 that that IN cord-007788-09t52zix 335 8 the the DT cord-007788-09t52zix 335 9 risk risk NN cord-007788-09t52zix 335 10 of of IN cord-007788-09t52zix 335 11 additional additional JJ cord-007788-09t52zix 335 12 injury injury NN cord-007788-09t52zix 335 13 to to IN cord-007788-09t52zix 335 14 the the DT cord-007788-09t52zix 335 15 urothelium urothelium NN cord-007788-09t52zix 335 16 is be VBZ cord-007788-09t52zix 335 17 minimised minimise VBN cord-007788-09t52zix 335 18 . . . cord-007788-09t52zix 336 1 Treatment treatment NN cord-007788-09t52zix 336 2 with with IN cord-007788-09t52zix 336 3 bladder bladder NN cord-007788-09t52zix 336 4 instillation instillation NN cord-007788-09t52zix 336 5 of of IN cord-007788-09t52zix 336 6 various various JJ cord-007788-09t52zix 336 7 compounds compound NNS cord-007788-09t52zix 336 8 such such JJ cord-007788-09t52zix 336 9 as as IN cord-007788-09t52zix 336 10 formalin formalin NN cord-007788-09t52zix 336 11 , , , cord-007788-09t52zix 336 12 alum alum NN cord-007788-09t52zix 336 13 , , , cord-007788-09t52zix 336 14 silver silver NN cord-007788-09t52zix 336 15 nitrate nitrate NN cord-007788-09t52zix 336 16 , , , cord-007788-09t52zix 336 17 sodium sodium NN cord-007788-09t52zix 336 18 hyalonurate hyalonurate NN cord-007788-09t52zix 336 19 , , , cord-007788-09t52zix 336 20 prostaglandins prostaglandin NNS cord-007788-09t52zix 336 21 , , , cord-007788-09t52zix 336 22 GM GM NNP cord-007788-09t52zix 336 23 - - HYPH cord-007788-09t52zix 336 24 CSF CSF NNP cord-007788-09t52zix 336 25 , , , cord-007788-09t52zix 336 26 fibrin fibrin NN cord-007788-09t52zix 336 27 glue glue NN cord-007788-09t52zix 336 28 , , , cord-007788-09t52zix 336 29 cidofovir cidofovir NNS cord-007788-09t52zix 336 30 , , , cord-007788-09t52zix 336 31 ciprofloxacin ciprofloxacin NN cord-007788-09t52zix 336 32 or or CC cord-007788-09t52zix 336 33 ribavirin ribavirin NN cord-007788-09t52zix 336 34 has have VBZ cord-007788-09t52zix 336 35 been be VBN cord-007788-09t52zix 336 36 reported report VBN cord-007788-09t52zix 336 37 as as IN cord-007788-09t52zix 336 38 effective effective JJ cord-007788-09t52zix 336 39 , , , cord-007788-09t52zix 336 40 but but CC cord-007788-09t52zix 336 41 experiences experience NNS cord-007788-09t52zix 336 42 are be VBP cord-007788-09t52zix 336 43 still still RB cord-007788-09t52zix 336 44 limited limited JJ cord-007788-09t52zix 336 45 ( ( -LRB- cord-007788-09t52zix 336 46 Carreras Carreras NNP cord-007788-09t52zix 336 47 2012 2012 CD cord-007788-09t52zix 336 48 ) ) -RRB- cord-007788-09t52zix 336 49 . . . cord-007788-09t52zix 337 1 If if IN cord-007788-09t52zix 337 2 obstruction obstruction NN cord-007788-09t52zix 337 3 occurs occur VBZ cord-007788-09t52zix 337 4 , , , cord-007788-09t52zix 337 5 cystoscopy cystoscopy NN cord-007788-09t52zix 337 6 can can MD cord-007788-09t52zix 337 7 be be VB cord-007788-09t52zix 337 8 performed perform VBN cord-007788-09t52zix 337 9 . . . cord-007788-09t52zix 338 1 Selective selective JJ cord-007788-09t52zix 338 2 embolisation embolisation NN cord-007788-09t52zix 338 3 of of IN cord-007788-09t52zix 338 4 bladder bladder NN cord-007788-09t52zix 338 5 arteries artery NNS cord-007788-09t52zix 338 6 and and CC cord-007788-09t52zix 338 7 catheterisation catheterisation NN cord-007788-09t52zix 338 8 of of IN cord-007788-09t52zix 338 9 both both DT cord-007788-09t52zix 338 10 ureters ureter NNS cord-007788-09t52zix 338 11 to to TO cord-007788-09t52zix 338 12 rest rest VB cord-007788-09t52zix 338 13 the the DT cord-007788-09t52zix 338 14 bladder bladder NN cord-007788-09t52zix 338 15 are be VBP cord-007788-09t52zix 338 16 actions action NNS cord-007788-09t52zix 338 17 that that WDT cord-007788-09t52zix 338 18 can can MD cord-007788-09t52zix 338 19 be be VB cord-007788-09t52zix 338 20 taken take VBN cord-007788-09t52zix 338 21 in in IN cord-007788-09t52zix 338 22 severe severe JJ cord-007788-09t52zix 338 23 cases case NNS cord-007788-09t52zix 338 24 . . . cord-007788-09t52zix 339 1 Cystectomy Cystectomy NNP cord-007788-09t52zix 339 2 remains remain VBZ cord-007788-09t52zix 339 3 the the DT cord-007788-09t52zix 339 4 last last JJ cord-007788-09t52zix 339 5 resort resort NN cord-007788-09t52zix 339 6 if if IN cord-007788-09t52zix 339 7 all all DT cord-007788-09t52zix 339 8 other other JJ cord-007788-09t52zix 339 9 treatment treatment NN cord-007788-09t52zix 339 10 attempts attempt NNS cord-007788-09t52zix 339 11 fail fail VBP cord-007788-09t52zix 339 12 . . . cord-007788-09t52zix 340 1 In in IN cord-007788-09t52zix 340 2 addition addition NN cord-007788-09t52zix 340 3 to to IN cord-007788-09t52zix 340 4 actions action NNS cord-007788-09t52zix 340 5 mentioned mention VBN cord-007788-09t52zix 340 6 above above RB cord-007788-09t52zix 340 7 , , , cord-007788-09t52zix 340 8 treatment treatment NN cord-007788-09t52zix 340 9 with with IN cord-007788-09t52zix 340 10 systemic systemic JJ cord-007788-09t52zix 340 11 administration administration NNP cord-007788-09t52zix 340 12 of of IN cord-007788-09t52zix 340 13 palifermin palifermin NNP cord-007788-09t52zix 340 14 , , , cord-007788-09t52zix 340 15 oral oral JJ cord-007788-09t52zix 340 16 oestrogens oestrogen NNS cord-007788-09t52zix 340 17 and and CC cord-007788-09t52zix 340 18 recombinant recombinant JJ cord-007788-09t52zix 340 19 FVIIa FVIIa NNS cord-007788-09t52zix 340 20 may may MD cord-007788-09t52zix 340 21 be be VB cord-007788-09t52zix 340 22 used use VBN cord-007788-09t52zix 340 23 ( ( -LRB- cord-007788-09t52zix 340 24 Carreras Carreras NNP cord-007788-09t52zix 340 25 2012 2012 CD cord-007788-09t52zix 340 26 ) ) -RRB- cord-007788-09t52zix 340 27 . . . cord-007788-09t52zix 341 1 Systemic systemic JJ cord-007788-09t52zix 341 2 antimicrobial antimicrobial JJ cord-007788-09t52zix 341 3 drugs drug NNS cord-007788-09t52zix 341 4 , , , cord-007788-09t52zix 341 5 e.g. e.g. RB cord-007788-09t52zix 341 6 cidofovir cidofovir NNS cord-007788-09t52zix 341 7 , , , cord-007788-09t52zix 341 8 ciprofloxacin ciprofloxacin NN cord-007788-09t52zix 341 9 and and CC cord-007788-09t52zix 341 10 ribavirin ribavirin NN cord-007788-09t52zix 341 11 , , , cord-007788-09t52zix 341 12 can can MD cord-007788-09t52zix 341 13 be be VB cord-007788-09t52zix 341 14 started start VBN cord-007788-09t52zix 341 15 , , , cord-007788-09t52zix 341 16 if if IN cord-007788-09t52zix 341 17 the the DT cord-007788-09t52zix 341 18 HC HC NNP cord-007788-09t52zix 341 19 is be VBZ cord-007788-09t52zix 341 20 confirmed confirm VBN cord-007788-09t52zix 341 21 or or CC cord-007788-09t52zix 341 22 likely likely RB cord-007788-09t52zix 341 23 attributable attributable JJ cord-007788-09t52zix 341 24 to to IN cord-007788-09t52zix 341 25 adeno adeno NN cord-007788-09t52zix 341 26 - - : cord-007788-09t52zix 341 27 or or CC cord-007788-09t52zix 341 28 BK BK NNP cord-007788-09t52zix 341 29 virus virus NN cord-007788-09t52zix 341 30 . . . cord-007788-09t52zix 342 1 Decreased decrease VBN cord-007788-09t52zix 342 2 immunosuppression immunosuppression NN cord-007788-09t52zix 342 3 could could MD cord-007788-09t52zix 342 4 be be VB cord-007788-09t52zix 342 5 considered consider VBN cord-007788-09t52zix 342 6 in in IN cord-007788-09t52zix 342 7 particular particular JJ cord-007788-09t52zix 342 8 in in IN cord-007788-09t52zix 342 9 cases case NNS cord-007788-09t52zix 342 10 of of IN cord-007788-09t52zix 342 11 relapsing relapse VBG cord-007788-09t52zix 342 12 viral viral JJ cord-007788-09t52zix 342 13 cystitis cystitis NN cord-007788-09t52zix 342 14 . . . cord-007788-09t52zix 343 1 Note note VB cord-007788-09t52zix 343 2 that that IN cord-007788-09t52zix 343 3 anticoagulants anticoagulant NNS cord-007788-09t52zix 343 4 such such JJ cord-007788-09t52zix 343 5 as as IN cord-007788-09t52zix 343 6 tranexamic tranexamic JJ cord-007788-09t52zix 343 7 acid acid NN cord-007788-09t52zix 343 8 and and CC cord-007788-09t52zix 343 9 aminocaproic aminocaproic NN cord-007788-09t52zix 343 10 acid acid NN cord-007788-09t52zix 343 11 are be VBP cord-007788-09t52zix 343 12 contraindicated contraindicated JJ cord-007788-09t52zix 343 13 in in IN cord-007788-09t52zix 343 14 HC HC NNP cord-007788-09t52zix 343 15 due due IN cord-007788-09t52zix 343 16 to to IN cord-007788-09t52zix 343 17 risk risk NN cord-007788-09t52zix 343 18 of of IN cord-007788-09t52zix 343 19 clot clot NN cord-007788-09t52zix 343 20 formation formation NN cord-007788-09t52zix 343 21 and and CC cord-007788-09t52zix 343 22 retention retention NN cord-007788-09t52zix 343 23 ! ! . cord-007788-09t52zix 344 1 Another another DT cord-007788-09t52zix 344 2 type type NN cord-007788-09t52zix 344 3 of of IN cord-007788-09t52zix 344 4 treatment treatment NN cord-007788-09t52zix 344 5 that that WDT cord-007788-09t52zix 344 6 has have VBZ cord-007788-09t52zix 344 7 proven prove VBN cord-007788-09t52zix 344 8 effective effective JJ cord-007788-09t52zix 344 9 is be VBZ cord-007788-09t52zix 344 10 hyperbaric hyperbaric NN cord-007788-09t52zix 344 11 oxygen oxygen NN cord-007788-09t52zix 345 1 ( ( -LRB- cord-007788-09t52zix 345 2 Savva Savva NNP cord-007788-09t52zix 345 3 - - HYPH cord-007788-09t52zix 345 4 Bordalo Bordalo NNP cord-007788-09t52zix 345 5 et et NNP cord-007788-09t52zix 345 6 al al NNP cord-007788-09t52zix 345 7 . . NNP cord-007788-09t52zix 345 8 2012 2012 CD cord-007788-09t52zix 345 9 ) ) -RRB- cord-007788-09t52zix 345 10 . . . cord-007788-09t52zix 346 1 The the DT cord-007788-09t52zix 346 2 patient patient NN cord-007788-09t52zix 346 3 then then RB cord-007788-09t52zix 346 4 receives receive VBZ cord-007788-09t52zix 346 5 100 100 CD cord-007788-09t52zix 346 6 % % NN cord-007788-09t52zix 346 7 oxygen oxygen NN cord-007788-09t52zix 346 8 in in IN cord-007788-09t52zix 346 9 a a DT cord-007788-09t52zix 346 10 hyperbaric hyperbaric NN cord-007788-09t52zix 346 11 chamber chamber NN cord-007788-09t52zix 346 12 but but CC cord-007788-09t52zix 346 13 limited limited JJ cord-007788-09t52zix 346 14 access access NN cord-007788-09t52zix 346 15 to to IN cord-007788-09t52zix 346 16 hyperbaric hyperbaric NN cord-007788-09t52zix 346 17 chambers chamber NNS cord-007788-09t52zix 346 18 , , , cord-007788-09t52zix 346 19 and and CC cord-007788-09t52zix 346 20 the the DT cord-007788-09t52zix 346 21 likely likely JJ cord-007788-09t52zix 346 22 need need NN cord-007788-09t52zix 346 23 and and CC cord-007788-09t52zix 346 24 inability inability NN cord-007788-09t52zix 346 25 for for IN cord-007788-09t52zix 346 26 the the DT cord-007788-09t52zix 346 27 patient patient NN cord-007788-09t52zix 346 28 to to TO cord-007788-09t52zix 346 29 move move VB cord-007788-09t52zix 346 30 to to IN cord-007788-09t52zix 346 31 another another DT cord-007788-09t52zix 346 32 treatment treatment NN cord-007788-09t52zix 346 33 unit unit NN cord-007788-09t52zix 346 34 often often RB cord-007788-09t52zix 346 35 makes make VBZ cord-007788-09t52zix 346 36 this this DT cord-007788-09t52zix 346 37 intervention intervention NN cord-007788-09t52zix 346 38 less less JJR cord-007788-09t52zix 346 39 of of IN cord-007788-09t52zix 346 40 an an DT cord-007788-09t52zix 346 41 option option NN cord-007788-09t52zix 346 42 . . . cord-007788-09t52zix 347 1 During during IN cord-007788-09t52zix 347 2 treatment treatment NN cord-007788-09t52zix 347 3 with with IN cord-007788-09t52zix 347 4 hyperhydration hyperhydration NN cord-007788-09t52zix 347 5 , , , cord-007788-09t52zix 347 6 the the DT cord-007788-09t52zix 347 7 same same JJ cord-007788-09t52zix 347 8 need need NN cord-007788-09t52zix 347 9 for for IN cord-007788-09t52zix 347 10 close close JJ cord-007788-09t52zix 347 11 monitoring monitoring NN cord-007788-09t52zix 347 12 and and CC cord-007788-09t52zix 347 13 assessments assessment NNS cord-007788-09t52zix 347 14 as as IN cord-007788-09t52zix 347 15 in in IN cord-007788-09t52zix 347 16 the the DT cord-007788-09t52zix 347 17 prophylactic prophylactic JJ cord-007788-09t52zix 347 18 setting setting NN cord-007788-09t52zix 347 19 applies applie NNS cord-007788-09t52zix 347 20 ( ( -LRB- cord-007788-09t52zix 347 21 see see VB cord-007788-09t52zix 347 22 above above RB cord-007788-09t52zix 347 23 ) ) -RRB- cord-007788-09t52zix 347 24 . . . cord-007788-09t52zix 348 1 Assess assess VB cord-007788-09t52zix 348 2 the the DT cord-007788-09t52zix 348 3 need need NN cord-007788-09t52zix 348 4 for for IN cord-007788-09t52zix 348 5 platelet platelet NN cord-007788-09t52zix 348 6 transfusion transfusion NN cord-007788-09t52zix 348 7 prior prior RB cord-007788-09t52zix 348 8 to to IN cord-007788-09t52zix 348 9 catheterisation catheterisation NN cord-007788-09t52zix 348 10 as as RB cord-007788-09t52zix 348 11 well well RB cord-007788-09t52zix 348 12 as as IN cord-007788-09t52zix 348 13 after after RB cord-007788-09t52zix 348 14 . . . cord-007788-09t52zix 349 1 Blood blood NN cord-007788-09t52zix 349 2 transfusions transfusion NNS cord-007788-09t52zix 349 3 may may MD cord-007788-09t52zix 349 4 also also RB cord-007788-09t52zix 349 5 be be VB cord-007788-09t52zix 349 6 necessary necessary JJ cord-007788-09t52zix 349 7 with with IN cord-007788-09t52zix 349 8 significant significant JJ cord-007788-09t52zix 349 9 blood blood NN cord-007788-09t52zix 349 10 loss loss NN cord-007788-09t52zix 349 11 . . . cord-007788-09t52zix 350 1 Standard standard JJ cord-007788-09t52zix 350 2 monitoring monitoring NN cord-007788-09t52zix 350 3 for for IN cord-007788-09t52zix 350 4 signs sign NNS cord-007788-09t52zix 350 5 of of IN cord-007788-09t52zix 350 6 infection infection NN cord-007788-09t52zix 350 7 , , , cord-007788-09t52zix 350 8 injury injury NN cord-007788-09t52zix 350 9 , , , cord-007788-09t52zix 350 10 pain pain NN cord-007788-09t52zix 350 11 , , , cord-007788-09t52zix 350 12 clot clot NN cord-007788-09t52zix 350 13 formation formation NN cord-007788-09t52zix 350 14 and and CC cord-007788-09t52zix 350 15 other other JJ cord-007788-09t52zix 350 16 potential potential JJ cord-007788-09t52zix 350 17 complications complication NNS cord-007788-09t52zix 350 18 from from IN cord-007788-09t52zix 350 19 the the DT cord-007788-09t52zix 350 20 urinary urinary JJ cord-007788-09t52zix 350 21 catheter catheter NN cord-007788-09t52zix 350 22 is be VBZ cord-007788-09t52zix 350 23 important important JJ cord-007788-09t52zix 350 24 . . . cord-007788-09t52zix 351 1 In in IN cord-007788-09t52zix 351 2 cases case NNS cord-007788-09t52zix 351 3 of of IN cord-007788-09t52zix 351 4 bladder bladder NN cord-007788-09t52zix 351 5 irrigation irrigation NN cord-007788-09t52zix 351 6 keeping keep VBG cord-007788-09t52zix 351 7 the the DT cord-007788-09t52zix 351 8 fluids fluid NNS cord-007788-09t52zix 351 9 for for IN cord-007788-09t52zix 351 10 irrigation irrigation NN cord-007788-09t52zix 351 11 at at IN cord-007788-09t52zix 351 12 ambient ambient JJ cord-007788-09t52zix 351 13 temperature temperature NN cord-007788-09t52zix 351 14 may may MD cord-007788-09t52zix 351 15 alleviate alleviate VB cord-007788-09t52zix 351 16 discomfort discomfort NN cord-007788-09t52zix 351 17 . . . cord-007788-09t52zix 352 1 Complications complication NNS cord-007788-09t52zix 352 2 of of IN cord-007788-09t52zix 352 3 the the DT cord-007788-09t52zix 352 4 irrigation irrigation NN cord-007788-09t52zix 352 5 can can MD cord-007788-09t52zix 352 6 be be VB cord-007788-09t52zix 352 7 prevented prevent VBN cord-007788-09t52zix 352 8 or or CC cord-007788-09t52zix 352 9 minimised minimise VBN cord-007788-09t52zix 352 10 by by IN cord-007788-09t52zix 352 11 close close JJ cord-007788-09t52zix 352 12 monitoring monitoring NN cord-007788-09t52zix 352 13 and and CC cord-007788-09t52zix 352 14 recording recording NN cord-007788-09t52zix 352 15 of of IN cord-007788-09t52zix 352 16 fluid fluid JJ cord-007788-09t52zix 352 17 balance balance NN cord-007788-09t52zix 352 18 . . . cord-007788-09t52zix 353 1 It -PRON- PRP cord-007788-09t52zix 353 2 is be VBZ cord-007788-09t52zix 353 3 also also RB cord-007788-09t52zix 353 4 important important JJ cord-007788-09t52zix 353 5 to to TO cord-007788-09t52zix 353 6 maintain maintain VB cord-007788-09t52zix 353 7 patient patient JJ cord-007788-09t52zix 353 8 comfort comfort NN cord-007788-09t52zix 353 9 by by IN cord-007788-09t52zix 353 10 adequate adequate JJ cord-007788-09t52zix 353 11 pain pain NN cord-007788-09t52zix 353 12 management management NN cord-007788-09t52zix 353 13 and and CC cord-007788-09t52zix 353 14 general general JJ cord-007788-09t52zix 353 15 nursing nursing NN cord-007788-09t52zix 353 16 interventions intervention NNS cord-007788-09t52zix 353 17 such such JJ cord-007788-09t52zix 353 18 as as IN cord-007788-09t52zix 353 19 comfortable comfortable JJ cord-007788-09t52zix 353 20 positioning positioning NN cord-007788-09t52zix 353 21 and and CC cord-007788-09t52zix 353 22 assistance assistance NN cord-007788-09t52zix 353 23 with with IN cord-007788-09t52zix 353 24 personal personal JJ cord-007788-09t52zix 353 25 hygiene hygiene NN cord-007788-09t52zix 353 26 . . . cord-007788-09t52zix 354 1 The the DT cord-007788-09t52zix 354 2 need need NN cord-007788-09t52zix 354 3 for for IN cord-007788-09t52zix 354 4 information information NN cord-007788-09t52zix 354 5 and and CC cord-007788-09t52zix 354 6 psychological psychological JJ cord-007788-09t52zix 354 7 support support NN cord-007788-09t52zix 354 8 should should MD cord-007788-09t52zix 354 9 be be VB cord-007788-09t52zix 354 10 observed observe VBN cord-007788-09t52zix 354 11 for for IN cord-007788-09t52zix 354 12 both both DT cord-007788-09t52zix 354 13 patient patient NN cord-007788-09t52zix 354 14 and and CC cord-007788-09t52zix 354 15 family family NN cord-007788-09t52zix 354 16 . . . cord-007788-09t52zix 355 1 Since since IN cord-007788-09t52zix 355 2 in in IN cord-007788-09t52zix 355 3 particular particular JJ cord-007788-09t52zix 355 4 viral viral JJ cord-007788-09t52zix 355 5 HC HC NNP cord-007788-09t52zix 355 6 may may MD cord-007788-09t52zix 355 7 occur occur VB cord-007788-09t52zix 355 8 after after IN cord-007788-09t52zix 355 9 discharge discharge NN cord-007788-09t52zix 355 10 from from IN cord-007788-09t52zix 355 11 the the DT cord-007788-09t52zix 355 12 hospital hospital NN cord-007788-09t52zix 355 13 , , , cord-007788-09t52zix 355 14 careful careful JJ cord-007788-09t52zix 355 15 assessment assessment NN cord-007788-09t52zix 355 16 of of IN cord-007788-09t52zix 355 17 any any DT cord-007788-09t52zix 355 18 signs sign NNS cord-007788-09t52zix 355 19 and and CC cord-007788-09t52zix 355 20 symptoms symptom NNS cord-007788-09t52zix 355 21 related relate VBN cord-007788-09t52zix 355 22 to to IN cord-007788-09t52zix 355 23 the the DT cord-007788-09t52zix 355 24 urinary urinary JJ cord-007788-09t52zix 355 25 tract tract NN cord-007788-09t52zix 355 26 and and CC cord-007788-09t52zix 355 27 that that WDT cord-007788-09t52zix 355 28 may may MD cord-007788-09t52zix 355 29 indicate indicate VB cord-007788-09t52zix 355 30 viral viral JJ cord-007788-09t52zix 355 31 infection infection NN cord-007788-09t52zix 355 32 is be VBZ cord-007788-09t52zix 355 33 just just RB cord-007788-09t52zix 355 34 as as RB cord-007788-09t52zix 355 35 important important JJ cord-007788-09t52zix 355 36 in in IN cord-007788-09t52zix 355 37 the the DT cord-007788-09t52zix 355 38 outpatient outpatient NN cord-007788-09t52zix 355 39 setting setting NN cord-007788-09t52zix 355 40 . . . cord-007788-09t52zix 356 1 Assessments assessment NNS cord-007788-09t52zix 356 2 for for IN cord-007788-09t52zix 356 3 treatment treatment NN cord-007788-09t52zix 356 4 with with IN cord-007788-09t52zix 356 5 high high JJ cord-007788-09t52zix 356 6 dose dose NN cord-007788-09t52zix 356 7 2 2 CD cord-007788-09t52zix 356 8 g g NN cord-007788-09t52zix 356 9 / / SYM cord-007788-09t52zix 356 10 m m NNP cord-007788-09t52zix 356 11 2 2 CD cord-007788-09t52zix 356 12 or or CC cord-007788-09t52zix 356 13 4 4 CD cord-007788-09t52zix 357 1 g g NNP cord-007788-09t52zix 357 2 / / SYM cord-007788-09t52zix 357 3 m m NN cord-007788-09t52zix 357 4 2 2 CD cord-007788-09t52zix 357 5 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 357 6 ( ( -LRB- cord-007788-09t52zix 357 7 Cy Cy NNP cord-007788-09t52zix 357 8 ) ) -RRB- cord-007788-09t52zix 357 9 _SP cord-007788-09t52zix 358 1 Sinusoidal Sinusoidal NNP cord-007788-09t52zix 358 2 Obstruction Obstruction NNP cord-007788-09t52zix 358 3 Syndrome Syndrome NNP cord-007788-09t52zix 358 4 / / SYM cord-007788-09t52zix 358 5 Veno Veno NNP cord-007788-09t52zix 358 6 - - HYPH cord-007788-09t52zix 358 7 Occlusive Occlusive NNP cord-007788-09t52zix 358 8 Disease Disease NNP cord-007788-09t52zix 358 9 Sinusoidal Sinusoidal NNP cord-007788-09t52zix 358 10 obstruction obstruction NN cord-007788-09t52zix 358 11 syndrome syndrome NN cord-007788-09t52zix 358 12 ( ( -LRB- cord-007788-09t52zix 358 13 SOS SOS NNP cord-007788-09t52zix 358 14 ) ) -RRB- cord-007788-09t52zix 358 15 is be VBZ cord-007788-09t52zix 358 16 also also RB cord-007788-09t52zix 358 17 known know VBN cord-007788-09t52zix 358 18 as as IN cord-007788-09t52zix 358 19 veno veno NNP cord-007788-09t52zix 358 20 - - HYPH cord-007788-09t52zix 358 21 occlusive occlusive JJ cord-007788-09t52zix 358 22 disease disease NN cord-007788-09t52zix 358 23 ( ( -LRB- cord-007788-09t52zix 358 24 VOD VOD NNP cord-007788-09t52zix 358 25 ) ) -RRB- cord-007788-09t52zix 358 26 and and CC cord-007788-09t52zix 358 27 is be VBZ cord-007788-09t52zix 358 28 referred refer VBN cord-007788-09t52zix 358 29 to to IN cord-007788-09t52zix 358 30 as as IN cord-007788-09t52zix 358 31 SOS SOS NNP cord-007788-09t52zix 358 32 / / SYM cord-007788-09t52zix 358 33 VOD VOD NNP cord-007788-09t52zix 358 34 hereafter hereafter RB cord-007788-09t52zix 358 35 . . . cord-007788-09t52zix 359 1 Of of IN cord-007788-09t52zix 359 2 the the DT cord-007788-09t52zix 359 3 early early JJ cord-007788-09t52zix 359 4 complications complication NNS cord-007788-09t52zix 359 5 that that WDT cord-007788-09t52zix 359 6 are be VBP cord-007788-09t52zix 359 7 considered consider VBN cord-007788-09t52zix 359 8 to to TO cord-007788-09t52zix 359 9 be be VB cord-007788-09t52zix 359 10 of of IN cord-007788-09t52zix 359 11 vascular vascular JJ cord-007788-09t52zix 359 12 endothelial endothelial JJ cord-007788-09t52zix 359 13 origin origin NN cord-007788-09t52zix 359 14 , , , cord-007788-09t52zix 359 15 this this DT cord-007788-09t52zix 359 16 is be VBZ cord-007788-09t52zix 359 17 the the DT cord-007788-09t52zix 359 18 most most RBS cord-007788-09t52zix 359 19 described describe VBN cord-007788-09t52zix 359 20 . . . cord-007788-09t52zix 360 1 There there EX cord-007788-09t52zix 360 2 are be VBP cord-007788-09t52zix 360 3 diagnosis diagnosis NN cord-007788-09t52zix 360 4 and and CC cord-007788-09t52zix 360 5 severity severity NN cord-007788-09t52zix 360 6 criteria criterion NNS cord-007788-09t52zix 360 7 ( ( -LRB- cord-007788-09t52zix 360 8 McDonald McDonald NNP cord-007788-09t52zix 360 9 et et NNP cord-007788-09t52zix 360 10 al al NNP cord-007788-09t52zix 360 11 . . . cord-007788-09t52zix 360 12 1984 1984 CD cord-007788-09t52zix 361 1 ( ( -LRB- cord-007788-09t52zix 361 2 McDonald McDonald NNP cord-007788-09t52zix 361 3 et et NNP cord-007788-09t52zix 361 4 al al NNP cord-007788-09t52zix 361 5 . . NNP cord-007788-09t52zix 361 6 , , , cord-007788-09t52zix 361 7 1993 1993 CD cord-007788-09t52zix 362 1 Jones Jones NNP cord-007788-09t52zix 362 2 et et NNP cord-007788-09t52zix 362 3 al al NNP cord-007788-09t52zix 362 4 . . NNP cord-007788-09t52zix 362 5 1987 1987 CD cord-007788-09t52zix 362 6 ; ; : cord-007788-09t52zix 362 7 deLeve deLeve NNP cord-007788-09t52zix 362 8 et et NNP cord-007788-09t52zix 362 9 al al NNP cord-007788-09t52zix 362 10 . . . cord-007788-09t52zix 362 11 2009 2009 CD cord-007788-09t52zix 363 1 ; ; : cord-007788-09t52zix 363 2 Mohty Mohty NNP cord-007788-09t52zix 363 3 et et NNP cord-007788-09t52zix 363 4 al al NNP cord-007788-09t52zix 363 5 . . . cord-007788-09t52zix 363 6 2016 2016 CD cord-007788-09t52zix 363 7 ) ) -RRB- cord-007788-09t52zix 363 8 , , , cord-007788-09t52zix 363 9 although although IN cord-007788-09t52zix 363 10 the the DT cord-007788-09t52zix 363 11 EBMT EBMT NNP cord-007788-09t52zix 363 12 criteria criterion NNS cord-007788-09t52zix 363 13 proposed propose VBN cord-007788-09t52zix 363 14 in in IN cord-007788-09t52zix 363 15 2016 2016 CD cord-007788-09t52zix 364 1 ( ( -LRB- cord-007788-09t52zix 364 2 Mohty Mohty NNP cord-007788-09t52zix 364 3 et et FW cord-007788-09t52zix 364 4 al al NNP cord-007788-09t52zix 364 5 . . . cord-007788-09t52zix 364 6 2016 2016 CD cord-007788-09t52zix 364 7 ) ) -RRB- cord-007788-09t52zix 364 8 is be VBZ cord-007788-09t52zix 364 9 expected expect VBN cord-007788-09t52zix 364 10 to to TO cord-007788-09t52zix 364 11 be be VB cord-007788-09t52zix 364 12 further further RB cord-007788-09t52zix 364 13 validated validate VBN cord-007788-09t52zix 364 14 , , , cord-007788-09t52zix 364 15 and and CC cord-007788-09t52zix 364 16 there there EX cord-007788-09t52zix 364 17 is be VBZ cord-007788-09t52zix 364 18 approved approve VBN cord-007788-09t52zix 364 19 treatment treatment NN cord-007788-09t52zix 364 20 available available JJ cord-007788-09t52zix 364 21 . . . cord-007788-09t52zix 365 1 Careful careful JJ cord-007788-09t52zix 365 2 monitoring monitoring NN cord-007788-09t52zix 365 3 of of IN cord-007788-09t52zix 365 4 HSCT HSCT NNP cord-007788-09t52zix 365 5 patients patient NNS cord-007788-09t52zix 365 6 allows allow VBZ cord-007788-09t52zix 365 7 early early JJ cord-007788-09t52zix 365 8 detection detection NN cord-007788-09t52zix 365 9 of of IN cord-007788-09t52zix 365 10 SOS SOS NNP cord-007788-09t52zix 365 11 / / SYM cord-007788-09t52zix 365 12 VOD VOD NNP cord-007788-09t52zix 365 13 . . . cord-007788-09t52zix 366 1 Treatment treatment NN cord-007788-09t52zix 366 2 can can MD cord-007788-09t52zix 366 3 then then RB cord-007788-09t52zix 366 4 be be VB cord-007788-09t52zix 366 5 started start VBN cord-007788-09t52zix 366 6 without without IN cord-007788-09t52zix 366 7 delay delay NN cord-007788-09t52zix 366 8 , , , cord-007788-09t52zix 366 9 ultimately ultimately RB cord-007788-09t52zix 366 10 improving improve VBG cord-007788-09t52zix 366 11 patient patient JJ cord-007788-09t52zix 366 12 outcomes outcome NNS cord-007788-09t52zix 366 13 . . . cord-007788-09t52zix 367 1 From from IN cord-007788-09t52zix 367 2 pre pre JJ cord-007788-09t52zix 367 3 - - JJ cord-007788-09t52zix 367 4 transplant transplant JJ cord-007788-09t52zix 367 5 assessment assessment NN cord-007788-09t52zix 367 6 to to IN cord-007788-09t52zix 367 7 medical medical JJ cord-007788-09t52zix 367 8 management management NN cord-007788-09t52zix 367 9 and and CC cord-007788-09t52zix 367 10 overall overall JJ cord-007788-09t52zix 367 11 care care NN cord-007788-09t52zix 367 12 of of IN cord-007788-09t52zix 367 13 the the DT cord-007788-09t52zix 367 14 patient patient NN cord-007788-09t52zix 367 15 , , , cord-007788-09t52zix 367 16 nurses nurse NNS cord-007788-09t52zix 367 17 thus thus RB cord-007788-09t52zix 367 18 have have VBP cord-007788-09t52zix 367 19 an an DT cord-007788-09t52zix 367 20 essential essential JJ cord-007788-09t52zix 367 21 role role NN cord-007788-09t52zix 367 22 to to TO cord-007788-09t52zix 367 23 play play VB cord-007788-09t52zix 367 24 as as IN cord-007788-09t52zix 367 25 part part NN cord-007788-09t52zix 367 26 of of IN cord-007788-09t52zix 367 27 a a DT cord-007788-09t52zix 367 28 multidisciplinary multidisciplinary JJ cord-007788-09t52zix 367 29 team team NN cord-007788-09t52zix 367 30 ( ( -LRB- cord-007788-09t52zix 367 31 Wallhult Wallhult NNP cord-007788-09t52zix 367 32 et et FW cord-007788-09t52zix 367 33 al al NNP cord-007788-09t52zix 367 34 . . . cord-007788-09t52zix 367 35 2017 2017 CD cord-007788-09t52zix 367 36 ) ) -RRB- cord-007788-09t52zix 367 37 . . . cord-007788-09t52zix 368 1 There there EX cord-007788-09t52zix 368 2 are be VBP cord-007788-09t52zix 368 3 specific specific JJ cord-007788-09t52zix 368 4 differences difference NNS cord-007788-09t52zix 368 5 between between IN cord-007788-09t52zix 368 6 the the DT cord-007788-09t52zix 368 7 clinical clinical JJ cord-007788-09t52zix 368 8 presentation presentation NN cord-007788-09t52zix 368 9 of of IN cord-007788-09t52zix 368 10 SOS SOS NNP cord-007788-09t52zix 368 11 / / SYM cord-007788-09t52zix 368 12 VOD VOD NNP cord-007788-09t52zix 368 13 in in IN cord-007788-09t52zix 368 14 adults adult NNS cord-007788-09t52zix 368 15 versus versus IN cord-007788-09t52zix 368 16 in in IN cord-007788-09t52zix 368 17 children child NNS cord-007788-09t52zix 368 18 which which WDT cord-007788-09t52zix 368 19 has have VBZ cord-007788-09t52zix 368 20 not not RB cord-007788-09t52zix 368 21 been be VBN cord-007788-09t52zix 368 22 reflected reflect VBN cord-007788-09t52zix 368 23 in in IN cord-007788-09t52zix 368 24 the the DT cord-007788-09t52zix 368 25 older old JJR cord-007788-09t52zix 368 26 diagnosis diagnosis NN cord-007788-09t52zix 368 27 and and CC cord-007788-09t52zix 368 28 severity severity NN cord-007788-09t52zix 368 29 criteria criterion NNS cord-007788-09t52zix 368 30 . . . cord-007788-09t52zix 369 1 For for IN cord-007788-09t52zix 369 2 this this DT cord-007788-09t52zix 369 3 reason reason NN cord-007788-09t52zix 369 4 , , , cord-007788-09t52zix 369 5 EBMT EBMT NNP cord-007788-09t52zix 369 6 has have VBZ cord-007788-09t52zix 369 7 also also RB cord-007788-09t52zix 369 8 developed develop VBN cord-007788-09t52zix 369 9 a a DT cord-007788-09t52zix 369 10 classification classification NN cord-007788-09t52zix 369 11 for for IN cord-007788-09t52zix 369 12 diagnosis diagnosis NN cord-007788-09t52zix 369 13 and and CC cord-007788-09t52zix 369 14 severity severity NN cord-007788-09t52zix 369 15 criteria criterion NNS cord-007788-09t52zix 369 16 for for IN cord-007788-09t52zix 369 17 SOS SOS NNP cord-007788-09t52zix 369 18 / / SYM cord-007788-09t52zix 369 19 VOD VOD NNP cord-007788-09t52zix 369 20 in in IN cord-007788-09t52zix 369 21 paediatric paediatric JJ cord-007788-09t52zix 369 22 patients patient NNS cord-007788-09t52zix 370 1 ( ( -LRB- cord-007788-09t52zix 370 2 Corbacioglu Corbacioglu NNP cord-007788-09t52zix 370 3 et et NNP cord-007788-09t52zix 370 4 al al NNP cord-007788-09t52zix 370 5 . . . cord-007788-09t52zix 370 6 2017 2017 CD cord-007788-09t52zix 370 7 ) ) -RRB- cord-007788-09t52zix 370 8 . . . cord-007788-09t52zix 371 1 The the DT cord-007788-09t52zix 371 2 information information NN cord-007788-09t52zix 371 3 presented present VBN cord-007788-09t52zix 371 4 below below RB cord-007788-09t52zix 371 5 is be VBZ cord-007788-09t52zix 371 6 related relate VBN cord-007788-09t52zix 371 7 to to IN cord-007788-09t52zix 371 8 adults adult NNS cord-007788-09t52zix 371 9 . . . cord-007788-09t52zix 372 1 For for IN cord-007788-09t52zix 372 2 the the DT cord-007788-09t52zix 372 3 paediatric paediatric JJ cord-007788-09t52zix 372 4 population population NN cord-007788-09t52zix 372 5 , , , cord-007788-09t52zix 372 6 please please UH cord-007788-09t52zix 372 7 see see VB cord-007788-09t52zix 372 8 original original JJ cord-007788-09t52zix 372 9 article article NN cord-007788-09t52zix 372 10 and/or and/or CC cord-007788-09t52zix 372 11 the the DT cord-007788-09t52zix 372 12 VOD VOD NNP cord-007788-09t52zix 372 13 learning learning NN cord-007788-09t52zix 372 14 programme programme NN cord-007788-09t52zix 372 15 on on IN cord-007788-09t52zix 372 16 the the DT cord-007788-09t52zix 372 17 EBMT EBMT NNP cord-007788-09t52zix 372 18 website website NN cord-007788-09t52zix 372 19 . . . cord-007788-09t52zix 372 20 _SP cord-007788-09t52zix 373 1 When when WRB cord-007788-09t52zix 373 2 drugs drug NNS cord-007788-09t52zix 373 3 used use VBN cord-007788-09t52zix 373 4 in in IN cord-007788-09t52zix 373 5 haematopoietic haematopoietic JJ cord-007788-09t52zix 373 6 stem stem NN cord-007788-09t52zix 373 7 cell cell NN cord-007788-09t52zix 373 8 transplant transplant NN cord-007788-09t52zix 373 9 ( ( -LRB- cord-007788-09t52zix 373 10 HSCT HSCT NNP cord-007788-09t52zix 373 11 ) ) -RRB- cord-007788-09t52zix 373 12 conditioning conditioning NN cord-007788-09t52zix 373 13 regimens regimen NNS cord-007788-09t52zix 373 14 are be VBP cord-007788-09t52zix 373 15 metabolised metabolise VBN cord-007788-09t52zix 373 16 in in IN cord-007788-09t52zix 373 17 the the DT cord-007788-09t52zix 373 18 liver liver NN cord-007788-09t52zix 373 19 , , , cord-007788-09t52zix 373 20 it -PRON- PRP cord-007788-09t52zix 373 21 results result VBZ cord-007788-09t52zix 373 22 in in IN cord-007788-09t52zix 373 23 toxic toxic JJ cord-007788-09t52zix 373 24 metabolites metabolite NNS cord-007788-09t52zix 373 25 being be VBG cord-007788-09t52zix 373 26 produced produce VBN cord-007788-09t52zix 373 27 by by IN cord-007788-09t52zix 373 28 the the DT cord-007788-09t52zix 373 29 hepatocytes hepatocyte NNS cord-007788-09t52zix 373 30 . . . cord-007788-09t52zix 374 1 The the DT cord-007788-09t52zix 374 2 metabolites metabolite NNS cord-007788-09t52zix 374 3 trigger trigger VBP cord-007788-09t52zix 374 4 the the DT cord-007788-09t52zix 374 5 activation activation NN cord-007788-09t52zix 374 6 , , , cord-007788-09t52zix 374 7 damage damage NN cord-007788-09t52zix 374 8 and and CC cord-007788-09t52zix 374 9 inflammation inflammation NN cord-007788-09t52zix 374 10 of of IN cord-007788-09t52zix 374 11 the the DT cord-007788-09t52zix 374 12 endothelial endothelial JJ cord-007788-09t52zix 374 13 cells cell NNS cord-007788-09t52zix 374 14 lining line VBG cord-007788-09t52zix 374 15 the the DT cord-007788-09t52zix 374 16 sinusoids sinusoid NNS cord-007788-09t52zix 374 17 ( ( -LRB- cord-007788-09t52zix 374 18 sinusoids sinusoid NNS cord-007788-09t52zix 374 19 being be VBG cord-007788-09t52zix 374 20 small small JJ cord-007788-09t52zix 374 21 capillary capillary JJ cord-007788-09t52zix 374 22 - - HYPH cord-007788-09t52zix 374 23 like like JJ cord-007788-09t52zix 374 24 blood blood NN cord-007788-09t52zix 374 25 vessels vessel NNS cord-007788-09t52zix 374 26 in in IN cord-007788-09t52zix 374 27 the the DT cord-007788-09t52zix 374 28 liver liver NN cord-007788-09t52zix 374 29 ) ) -RRB- cord-007788-09t52zix 374 30 . . . cord-007788-09t52zix 375 1 This this DT cord-007788-09t52zix 375 2 trigger trigger NN cord-007788-09t52zix 375 3 mechanism mechanism NN cord-007788-09t52zix 375 4 can can MD cord-007788-09t52zix 375 5 start start VB cord-007788-09t52zix 375 6 as as RB cord-007788-09t52zix 375 7 soon soon RB cord-007788-09t52zix 375 8 as as IN cord-007788-09t52zix 375 9 the the DT cord-007788-09t52zix 375 10 conditioning conditioning NN cord-007788-09t52zix 375 11 treatment treatment NN cord-007788-09t52zix 375 12 is be VBZ cord-007788-09t52zix 375 13 administered administer VBN cord-007788-09t52zix 375 14 . . . cord-007788-09t52zix 376 1 The the DT cord-007788-09t52zix 376 2 activated activate VBN cord-007788-09t52zix 376 3 sinusoidal sinusoidal JJ cord-007788-09t52zix 376 4 endothelial endothelial JJ cord-007788-09t52zix 376 5 cells cell NNS cord-007788-09t52zix 376 6 release release VBP cord-007788-09t52zix 376 7 inflammatory inflammatory JJ cord-007788-09t52zix 376 8 cytokines cytokine NNS cord-007788-09t52zix 376 9 , , , cord-007788-09t52zix 376 10 chemokines chemokine NNS cord-007788-09t52zix 376 11 and and CC cord-007788-09t52zix 376 12 the the DT cord-007788-09t52zix 376 13 enzyme enzyme NN cord-007788-09t52zix 376 14 heparanase heparanase NN cord-007788-09t52zix 376 15 which which WDT cord-007788-09t52zix 376 16 break break VBP cord-007788-09t52zix 376 17 down down RP cord-007788-09t52zix 376 18 the the DT cord-007788-09t52zix 376 19 extracellular extracellular JJ cord-007788-09t52zix 376 20 matrix matrix NN cord-007788-09t52zix 376 21 that that WDT cord-007788-09t52zix 376 22 supports support VBZ cord-007788-09t52zix 376 23 the the DT cord-007788-09t52zix 376 24 structure structure NN cord-007788-09t52zix 376 25 of of IN cord-007788-09t52zix 376 26 the the DT cord-007788-09t52zix 376 27 sinusoids sinusoid NNS cord-007788-09t52zix 376 28 . . . cord-007788-09t52zix 377 1 The the DT cord-007788-09t52zix 377 2 endothelial endothelial JJ cord-007788-09t52zix 377 3 cells cell NNS cord-007788-09t52zix 377 4 are be VBP cord-007788-09t52zix 377 5 then then RB cord-007788-09t52zix 377 6 forced force VBN cord-007788-09t52zix 377 7 to to TO cord-007788-09t52zix 377 8 round round VB cord-007788-09t52zix 377 9 up up RP cord-007788-09t52zix 377 10 , , , cord-007788-09t52zix 377 11 and and CC cord-007788-09t52zix 377 12 gaps gap NNS cord-007788-09t52zix 377 13 form form VBP cord-007788-09t52zix 377 14 between between IN cord-007788-09t52zix 377 15 the the DT cord-007788-09t52zix 377 16 cells cell NNS cord-007788-09t52zix 377 17 . . . cord-007788-09t52zix 378 1 The the DT cord-007788-09t52zix 378 2 gaps gap NNS cord-007788-09t52zix 378 3 allow allow VBP cord-007788-09t52zix 378 4 for for IN cord-007788-09t52zix 378 5 red red JJ cord-007788-09t52zix 378 6 blood blood NN cord-007788-09t52zix 378 7 cells cell NNS cord-007788-09t52zix 378 8 , , , cord-007788-09t52zix 378 9 white white JJ cord-007788-09t52zix 378 10 blood blood NN cord-007788-09t52zix 378 11 cells cell NNS cord-007788-09t52zix 378 12 and and CC cord-007788-09t52zix 378 13 other other JJ cord-007788-09t52zix 378 14 cellular cellular JJ cord-007788-09t52zix 378 15 debris debris NN cord-007788-09t52zix 378 16 to to TO cord-007788-09t52zix 378 17 exit exit VB cord-007788-09t52zix 378 18 through through IN cord-007788-09t52zix 378 19 these these DT cord-007788-09t52zix 378 20 gaps gap NNS cord-007788-09t52zix 378 21 in in IN cord-007788-09t52zix 378 22 the the DT cord-007788-09t52zix 378 23 sinusoid sinusoid JJ cord-007788-09t52zix 378 24 walls wall NNS cord-007788-09t52zix 378 25 into into IN cord-007788-09t52zix 378 26 the the DT cord-007788-09t52zix 378 27 space space NN cord-007788-09t52zix 378 28 of of IN cord-007788-09t52zix 378 29 Disse Disse NNP cord-007788-09t52zix 378 30 . . . cord-007788-09t52zix 379 1 ( ( -LRB- cord-007788-09t52zix 379 2 The the DT cord-007788-09t52zix 379 3 space space NN cord-007788-09t52zix 379 4 of of IN cord-007788-09t52zix 379 5 Disse Disse NNP cord-007788-09t52zix 379 6 is be VBZ cord-007788-09t52zix 379 7 the the DT cord-007788-09t52zix 379 8 perisinusoidal perisinusoidal JJ cord-007788-09t52zix 379 9 space space NN cord-007788-09t52zix 379 10 that that WDT cord-007788-09t52zix 379 11 is be VBZ cord-007788-09t52zix 379 12 located locate VBN cord-007788-09t52zix 379 13 between between IN cord-007788-09t52zix 379 14 the the DT cord-007788-09t52zix 379 15 endothelium endothelium NN cord-007788-09t52zix 379 16 and and CC cord-007788-09t52zix 379 17 the the DT cord-007788-09t52zix 379 18 hepatocytes hepatocyte NNS cord-007788-09t52zix 379 19 . . . cord-007788-09t52zix 379 20 ) ) -RRB- cord-007788-09t52zix 380 1 When when WRB cord-007788-09t52zix 380 2 cells cell NNS cord-007788-09t52zix 380 3 and and CC cord-007788-09t52zix 380 4 debris debris NN cord-007788-09t52zix 380 5 accumulate accumulate VBP cord-007788-09t52zix 380 6 in in IN cord-007788-09t52zix 380 7 this this DT cord-007788-09t52zix 380 8 space space NN cord-007788-09t52zix 380 9 , , , cord-007788-09t52zix 380 10 the the DT cord-007788-09t52zix 380 11 sinusoids sinusoid NNS cord-007788-09t52zix 380 12 become become VBP cord-007788-09t52zix 380 13 narrower narrow JJR cord-007788-09t52zix 380 14 . . . cord-007788-09t52zix 381 1 Due due IN cord-007788-09t52zix 381 2 to to IN cord-007788-09t52zix 381 3 the the DT cord-007788-09t52zix 381 4 sinusoidal sinusoidal JJ cord-007788-09t52zix 381 5 damage damage NN cord-007788-09t52zix 381 6 , , , cord-007788-09t52zix 381 7 endothelial endothelial JJ cord-007788-09t52zix 381 8 cells cell NNS cord-007788-09t52zix 381 9 can can MD cord-007788-09t52zix 381 10 dissect dissect VB cord-007788-09t52zix 381 11 off off RP cord-007788-09t52zix 381 12 and and CC cord-007788-09t52zix 381 13 embolise embolise NN cord-007788-09t52zix 381 14 further further RB cord-007788-09t52zix 381 15 downstream downstream RB cord-007788-09t52zix 381 16 thus thus RB cord-007788-09t52zix 381 17 contribute contribute VBP cord-007788-09t52zix 381 18 to to IN cord-007788-09t52zix 381 19 the the DT cord-007788-09t52zix 381 20 narrowing narrowing NN cord-007788-09t52zix 381 21 . . . cord-007788-09t52zix 382 1 The the DT cord-007788-09t52zix 382 2 damage damage NN cord-007788-09t52zix 382 3 also also RB cord-007788-09t52zix 382 4 leads lead VBZ cord-007788-09t52zix 382 5 to to IN cord-007788-09t52zix 382 6 an an DT cord-007788-09t52zix 382 7 increase increase NN cord-007788-09t52zix 382 8 in in IN cord-007788-09t52zix 382 9 the the DT cord-007788-09t52zix 382 10 expression expression NN cord-007788-09t52zix 382 11 of of IN cord-007788-09t52zix 382 12 tissue tissue NN cord-007788-09t52zix 382 13 factor factor NN cord-007788-09t52zix 382 14 ( ( -LRB- cord-007788-09t52zix 382 15 TF TF NNP cord-007788-09t52zix 382 16 ) ) -RRB- cord-007788-09t52zix 382 17 and and CC cord-007788-09t52zix 382 18 plasminogen plasminogen NN cord-007788-09t52zix 382 19 activator activator NN cord-007788-09t52zix 382 20 inhibitor-1 inhibitor-1 NNP cord-007788-09t52zix 382 21 ( ( -LRB- cord-007788-09t52zix 382 22 PAI-1 PAI-1 NNP cord-007788-09t52zix 382 23 ) ) -RRB- cord-007788-09t52zix 382 24 . . . cord-007788-09t52zix 383 1 This this DT cord-007788-09t52zix 383 2 coagulopathy coagulopathy NN cord-007788-09t52zix 383 3 causes cause VBZ cord-007788-09t52zix 383 4 an an DT cord-007788-09t52zix 383 5 increase increase NN cord-007788-09t52zix 383 6 in in IN cord-007788-09t52zix 383 7 clot clot NN cord-007788-09t52zix 383 8 formation formation NN cord-007788-09t52zix 383 9 and and CC cord-007788-09t52zix 383 10 a a DT cord-007788-09t52zix 383 11 decrease decrease NN cord-007788-09t52zix 383 12 in in IN cord-007788-09t52zix 383 13 the the DT cord-007788-09t52zix 383 14 breakdown breakdown NN cord-007788-09t52zix 383 15 of of IN cord-007788-09t52zix 383 16 clots clot NNS cord-007788-09t52zix 383 17 . . . cord-007788-09t52zix 384 1 The the DT cord-007788-09t52zix 384 2 deposition deposition NN cord-007788-09t52zix 384 3 of of IN cord-007788-09t52zix 384 4 fibrin fibrin NN cord-007788-09t52zix 384 5 and and CC cord-007788-09t52zix 384 6 the the DT cord-007788-09t52zix 384 7 clot clot NN cord-007788-09t52zix 384 8 formation formation NN cord-007788-09t52zix 384 9 will will MD cord-007788-09t52zix 384 10 contribute contribute VB cord-007788-09t52zix 384 11 to to IN cord-007788-09t52zix 384 12 the the DT cord-007788-09t52zix 384 13 narrowing narrowing NN cord-007788-09t52zix 384 14 of of IN cord-007788-09t52zix 384 15 the the DT cord-007788-09t52zix 384 16 sinusoids sinusoid NNS cord-007788-09t52zix 384 17 and and CC cord-007788-09t52zix 384 18 may may MD cord-007788-09t52zix 384 19 ultimately ultimately RB cord-007788-09t52zix 384 20 lead lead VB cord-007788-09t52zix 384 21 to to IN cord-007788-09t52zix 384 22 hepatic hepatic JJ cord-007788-09t52zix 384 23 sinusoidal sinusoidal JJ cord-007788-09t52zix 384 24 obstruction obstruction NN cord-007788-09t52zix 384 25 . . . cord-007788-09t52zix 385 1 The the DT cord-007788-09t52zix 385 2 result result NN cord-007788-09t52zix 385 3 is be VBZ cord-007788-09t52zix 385 4 SOS SOS NNP cord-007788-09t52zix 385 5 / / SYM cord-007788-09t52zix 385 6 VOD VOD NNP cord-007788-09t52zix 385 7 which which WDT cord-007788-09t52zix 385 8 is be VBZ cord-007788-09t52zix 385 9 characterised characterise VBN cord-007788-09t52zix 385 10 by by IN cord-007788-09t52zix 385 11 obstruction obstruction NN cord-007788-09t52zix 385 12 of of IN cord-007788-09t52zix 385 13 the the DT cord-007788-09t52zix 385 14 sinusoids sinusoid NNS cord-007788-09t52zix 385 15 , , , cord-007788-09t52zix 385 16 portal portal JJ cord-007788-09t52zix 385 17 vein vein NN cord-007788-09t52zix 385 18 hypotension hypotension NN cord-007788-09t52zix 385 19 and and CC cord-007788-09t52zix 385 20 reduced reduce VBN cord-007788-09t52zix 385 21 hepatic hepatic JJ cord-007788-09t52zix 385 22 venous venous JJ cord-007788-09t52zix 385 23 outflow outflow NN cord-007788-09t52zix 385 24 . . . cord-007788-09t52zix 386 1 Severe severe JJ cord-007788-09t52zix 386 2 cases case NNS cord-007788-09t52zix 386 3 can can MD cord-007788-09t52zix 386 4 progress progress VB cord-007788-09t52zix 386 5 to to IN cord-007788-09t52zix 386 6 multi multi JJ cord-007788-09t52zix 386 7 - - JJ cord-007788-09t52zix 386 8 organ organ JJ cord-007788-09t52zix 386 9 dysfunction dysfunction NN cord-007788-09t52zix 387 1 ( ( -LRB- cord-007788-09t52zix 387 2 MOD)/multiorgan mod)/multiorgan JJ cord-007788-09t52zix 387 3 failure failure NN cord-007788-09t52zix 387 4 ( ( -LRB- cord-007788-09t52zix 387 5 MOF MOF NNP cord-007788-09t52zix 387 6 ) ) -RRB- cord-007788-09t52zix 387 7 and and CC cord-007788-09t52zix 387 8 death death NN cord-007788-09t52zix 387 9 . . . cord-007788-09t52zix 388 1 SOS SOS NNP cord-007788-09t52zix 388 2 / / SYM cord-007788-09t52zix 388 3 VOD VOD NNP cord-007788-09t52zix 388 4 usually usually RB cord-007788-09t52zix 388 5 develops develop VBZ cord-007788-09t52zix 388 6 before before IN cord-007788-09t52zix 388 7 day day NN cord-007788-09t52zix 388 8 +21 +21 NNS cord-007788-09t52zix 388 9 after after IN cord-007788-09t52zix 388 10 HSCT HSCT NNP cord-007788-09t52zix 388 11 with with IN cord-007788-09t52zix 388 12 a a DT cord-007788-09t52zix 388 13 peak peak NN cord-007788-09t52zix 388 14 incidence incidence NN cord-007788-09t52zix 388 15 around around IN cord-007788-09t52zix 388 16 day day NN cord-007788-09t52zix 388 17 12 12 CD cord-007788-09t52zix 388 18 , , , cord-007788-09t52zix 388 19 but but CC cord-007788-09t52zix 388 20 about about RB cord-007788-09t52zix 388 21 15 15 CD cord-007788-09t52zix 388 22 - - SYM cord-007788-09t52zix 388 23 20 20 CD cord-007788-09t52zix 388 24 % % NN cord-007788-09t52zix 388 25 of of IN cord-007788-09t52zix 388 26 the the DT cord-007788-09t52zix 388 27 SOS SOS NNP cord-007788-09t52zix 388 28 / / SYM cord-007788-09t52zix 388 29 VOD VOD NNP cord-007788-09t52zix 388 30 cases case NNS cord-007788-09t52zix 388 31 have have VBP cord-007788-09t52zix 388 32 a a DT cord-007788-09t52zix 388 33 late late JJ cord-007788-09t52zix 388 34 onset onset NN cord-007788-09t52zix 388 35 , , , cord-007788-09t52zix 388 36 after after IN cord-007788-09t52zix 388 37 day day NN cord-007788-09t52zix 388 38 +21 +21 CD cord-007788-09t52zix 388 39 . . . cord-007788-09t52zix 389 1 Although although IN cord-007788-09t52zix 389 2 relatively relatively RB cord-007788-09t52zix 389 3 rare rare JJ cord-007788-09t52zix 389 4 , , , cord-007788-09t52zix 389 5 SOS SOS NNP cord-007788-09t52zix 389 6 / / SYM cord-007788-09t52zix 389 7 VOD VOD NNP cord-007788-09t52zix 389 8 is be VBZ cord-007788-09t52zix 389 9 one one CD cord-007788-09t52zix 389 10 of of IN cord-007788-09t52zix 389 11 the the DT cord-007788-09t52zix 389 12 main main JJ cord-007788-09t52zix 389 13 causes cause NNS cord-007788-09t52zix 389 14 of of IN cord-007788-09t52zix 389 15 non non JJ cord-007788-09t52zix 389 16 - - JJ cord-007788-09t52zix 389 17 relapse relapse JJ cord-007788-09t52zix 389 18 , , , cord-007788-09t52zix 389 19 transplant transplant NN cord-007788-09t52zix 389 20 - - HYPH cord-007788-09t52zix 389 21 related relate VBN cord-007788-09t52zix 389 22 mortality mortality NN cord-007788-09t52zix 389 23 . . . cord-007788-09t52zix 390 1 A a DT cord-007788-09t52zix 390 2 mean mean JJ cord-007788-09t52zix 390 3 incidence incidence NN cord-007788-09t52zix 390 4 of of IN cord-007788-09t52zix 390 5 14 14 CD cord-007788-09t52zix 390 6 % % NN cord-007788-09t52zix 390 7 ( ( -LRB- cord-007788-09t52zix 390 8 Coppell Coppell NNP cord-007788-09t52zix 390 9 et et NNP cord-007788-09t52zix 390 10 al al NNP cord-007788-09t52zix 390 11 . . NNP cord-007788-09t52zix 390 12 2010 2010 CD cord-007788-09t52zix 390 13 ) ) -RRB- cord-007788-09t52zix 390 14 has have VBZ cord-007788-09t52zix 390 15 been be VBN cord-007788-09t52zix 390 16 reported report VBN cord-007788-09t52zix 390 17 , , , cord-007788-09t52zix 390 18 but but CC cord-007788-09t52zix 390 19 it -PRON- PRP cord-007788-09t52zix 390 20 varies vary VBZ cord-007788-09t52zix 390 21 with with IN cord-007788-09t52zix 390 22 the the DT cord-007788-09t52zix 390 23 diagnostic diagnostic JJ cord-007788-09t52zix 390 24 criteria criterion NNS cord-007788-09t52zix 390 25 , , , cord-007788-09t52zix 390 26 depending depend VBG cord-007788-09t52zix 390 27 whether whether IN cord-007788-09t52zix 390 28 the the DT cord-007788-09t52zix 390 29 Seattle Seattle NNP cord-007788-09t52zix 390 30 ( ( -LRB- cord-007788-09t52zix 390 31 McDonald McDonald NNP cord-007788-09t52zix 390 32 et et NNP cord-007788-09t52zix 390 33 al al NNP cord-007788-09t52zix 390 34 . . . cord-007788-09t52zix 391 1 1984 1984 CD cord-007788-09t52zix 392 1 ( ( -LRB- cord-007788-09t52zix 392 2 McDonald McDonald NNP cord-007788-09t52zix 392 3 et et NNP cord-007788-09t52zix 392 4 al al NNP cord-007788-09t52zix 392 5 . . NNP cord-007788-09t52zix 392 6 , , , cord-007788-09t52zix 392 7 1993 1993 CD cord-007788-09t52zix 392 8 or or CC cord-007788-09t52zix 392 9 the the DT cord-007788-09t52zix 392 10 slightly slightly RB cord-007788-09t52zix 392 11 stricter strict JJR cord-007788-09t52zix 392 12 Baltimore Baltimore NNP cord-007788-09t52zix 392 13 criteria criterion NNS cord-007788-09t52zix 392 14 ( ( -LRB- cord-007788-09t52zix 392 15 Jones Jones NNP cord-007788-09t52zix 392 16 et et NNP cord-007788-09t52zix 392 17 al al NNP cord-007788-09t52zix 392 18 . . NNP cord-007788-09t52zix 392 19 1987 1987 CD cord-007788-09t52zix 392 20 ) ) -RRB- cord-007788-09t52zix 392 21 have have VBP cord-007788-09t52zix 392 22 been be VBN cord-007788-09t52zix 392 23 used use VBN cord-007788-09t52zix 392 24 . . . cord-007788-09t52zix 393 1 It -PRON- PRP cord-007788-09t52zix 393 2 will will MD cord-007788-09t52zix 393 3 also also RB cord-007788-09t52zix 393 4 depend depend VB cord-007788-09t52zix 393 5 on on IN cord-007788-09t52zix 393 6 risk risk NN cord-007788-09t52zix 393 7 factors factor NNS cord-007788-09t52zix 393 8 including include VBG cord-007788-09t52zix 393 9 intensity intensity NN cord-007788-09t52zix 393 10 of of IN cord-007788-09t52zix 393 11 conditioning conditioning NN cord-007788-09t52zix 393 12 regimen regimen NN cord-007788-09t52zix 393 13 and and CC cord-007788-09t52zix 393 14 type type NN cord-007788-09t52zix 393 15 of of IN cord-007788-09t52zix 393 16 transplant transplant NN cord-007788-09t52zix 393 17 . . . cord-007788-09t52zix 394 1 After after IN cord-007788-09t52zix 394 2 allo allo NN cord-007788-09t52zix 394 3 - - HYPH cord-007788-09t52zix 394 4 HSCT HSCT NNP cord-007788-09t52zix 394 5 with with IN cord-007788-09t52zix 394 6 myeloablative myeloablative JJ cord-007788-09t52zix 394 7 conditioning conditioning NN cord-007788-09t52zix 394 8 ( ( -LRB- cord-007788-09t52zix 394 9 MAC MAC NNP cord-007788-09t52zix 394 10 ) ) -RRB- cord-007788-09t52zix 394 11 , , , cord-007788-09t52zix 394 12 the the DT cord-007788-09t52zix 394 13 incidence incidence NN cord-007788-09t52zix 394 14 is be VBZ cord-007788-09t52zix 394 15 approximately approximately RB cord-007788-09t52zix 394 16 10 10 CD cord-007788-09t52zix 394 17 - - SYM cord-007788-09t52zix 394 18 15 15 CD cord-007788-09t52zix 394 19 % % NN cord-007788-09t52zix 394 20 , , , cord-007788-09t52zix 394 21 but but CC cord-007788-09t52zix 394 22 if if IN cord-007788-09t52zix 394 23 reduced reduce VBN cord-007788-09t52zix 394 24 intensity intensity NN cord-007788-09t52zix 394 25 conditioning conditioning NN cord-007788-09t52zix 394 26 ( ( -LRB- cord-007788-09t52zix 394 27 RIC RIC NNP cord-007788-09t52zix 394 28 ) ) -RRB- cord-007788-09t52zix 394 29 is be VBZ cord-007788-09t52zix 394 30 used use VBN cord-007788-09t52zix 394 31 , , , cord-007788-09t52zix 394 32 the the DT cord-007788-09t52zix 394 33 incidence incidence NN cord-007788-09t52zix 394 34 is be VBZ cord-007788-09t52zix 394 35 < < XX cord-007788-09t52zix 394 36 5 5 CD cord-007788-09t52zix 394 37 % % NN cord-007788-09t52zix 394 38 . . . cord-007788-09t52zix 395 1 This this DT cord-007788-09t52zix 395 2 is be VBZ cord-007788-09t52zix 395 3 the the DT cord-007788-09t52zix 395 4 same same JJ cord-007788-09t52zix 395 5 incidence incidence NN cord-007788-09t52zix 395 6 as as IN cord-007788-09t52zix 395 7 for for IN cord-007788-09t52zix 395 8 auto auto NN cord-007788-09t52zix 395 9 - - HYPH cord-007788-09t52zix 395 10 HSCT HSCT NNP cord-007788-09t52zix 395 11 . . . cord-007788-09t52zix 396 1 Early early JJ cord-007788-09t52zix 396 2 - - HYPH cord-007788-09t52zix 396 3 stage stage NN cord-007788-09t52zix 396 4 SOS SOS NNP cord-007788-09t52zix 396 5 / / SYM cord-007788-09t52zix 396 6 VOD VOD NNP cord-007788-09t52zix 396 7 , , , cord-007788-09t52zix 396 8 mild mild JJ cord-007788-09t52zix 396 9 SOS SOS NNP cord-007788-09t52zix 396 10 / / SYM cord-007788-09t52zix 396 11 VOD VOD NNP cord-007788-09t52zix 396 12 , , , cord-007788-09t52zix 396 13 may may MD cord-007788-09t52zix 396 14 not not RB cord-007788-09t52zix 396 15 be be VB cord-007788-09t52zix 396 16 particularly particularly RB cord-007788-09t52zix 396 17 well well RB cord-007788-09t52zix 396 18 - - HYPH cord-007788-09t52zix 396 19 recognised recognise VBN cord-007788-09t52zix 396 20 since since IN cord-007788-09t52zix 396 21 the the DT cord-007788-09t52zix 396 22 symptoms symptom NNS cord-007788-09t52zix 396 23 are be VBP cord-007788-09t52zix 396 24 subtle subtle JJ cord-007788-09t52zix 396 25 , , , cord-007788-09t52zix 396 26 may may MD cord-007788-09t52zix 396 27 not not RB cord-007788-09t52zix 396 28 require require VB cord-007788-09t52zix 396 29 treatment treatment NN cord-007788-09t52zix 396 30 and and CC cord-007788-09t52zix 396 31 spontaneously spontaneously RB cord-007788-09t52zix 396 32 resolve resolve VB cord-007788-09t52zix 396 33 within within IN cord-007788-09t52zix 396 34 a a DT cord-007788-09t52zix 396 35 few few JJ cord-007788-09t52zix 396 36 weeks week NNS cord-007788-09t52zix 396 37 . . . cord-007788-09t52zix 397 1 Unrecognised Unrecognised NNP cord-007788-09t52zix 397 2 SOS SOS NNP cord-007788-09t52zix 397 3 / / SYM cord-007788-09t52zix 397 4 VOD VOD NNP cord-007788-09t52zix 397 5 may may MD cord-007788-09t52zix 397 6 however however RB cord-007788-09t52zix 397 7 progress progress VB cord-007788-09t52zix 397 8 , , , cord-007788-09t52zix 397 9 sometimes sometimes RB cord-007788-09t52zix 397 10 very very RB cord-007788-09t52zix 397 11 rapidly rapidly RB cord-007788-09t52zix 397 12 , , , cord-007788-09t52zix 397 13 into into IN cord-007788-09t52zix 397 14 moderate moderate JJ cord-007788-09t52zix 397 15 or or CC cord-007788-09t52zix 397 16 severe severe JJ cord-007788-09t52zix 397 17 . . . cord-007788-09t52zix 398 1 Severe severe JJ cord-007788-09t52zix 398 2 SOS SOS NNP cord-007788-09t52zix 398 3 / / SYM cord-007788-09t52zix 398 4 VOD VOD NNP cord-007788-09t52zix 398 5 is be VBZ cord-007788-09t52zix 398 6 associated associate VBN cord-007788-09t52zix 398 7 with with IN cord-007788-09t52zix 398 8 MOD mod NN cord-007788-09t52zix 398 9 / / SYM cord-007788-09t52zix 398 10 MOF MOF NNP cord-007788-09t52zix 398 11 and and CC cord-007788-09t52zix 398 12 a a DT cord-007788-09t52zix 398 13 mortality mortality NN cord-007788-09t52zix 398 14 rate rate NN cord-007788-09t52zix 398 15 of of IN cord-007788-09t52zix 398 16 84 84 CD cord-007788-09t52zix 398 17 % % NN cord-007788-09t52zix 398 18 . . . cord-007788-09t52zix 399 1 The the DT cord-007788-09t52zix 399 2 risk risk NN cord-007788-09t52zix 399 3 factors factor NNS cord-007788-09t52zix 399 4 for for IN cord-007788-09t52zix 399 5 SOS SOS NNP cord-007788-09t52zix 399 6 / / SYM cord-007788-09t52zix 399 7 VOD VOD NNP cord-007788-09t52zix 399 8 can can MD cord-007788-09t52zix 399 9 be be VB cord-007788-09t52zix 399 10 divided divide VBN cord-007788-09t52zix 399 11 into into IN cord-007788-09t52zix 399 12 patient patient NN cord-007788-09t52zix 399 13 - - HYPH cord-007788-09t52zix 399 14 and and CC cord-007788-09t52zix 399 15 disease disease NN cord-007788-09t52zix 399 16 - - HYPH cord-007788-09t52zix 399 17 related relate VBN cord-007788-09t52zix 399 18 and and CC cord-007788-09t52zix 399 19 transplantrelated transplantrelated JJ cord-007788-09t52zix 399 20 risk risk NN cord-007788-09t52zix 399 21 factors factor NNS cord-007788-09t52zix 399 22 ( ( -LRB- cord-007788-09t52zix 399 23 Mohty Mohty NNP cord-007788-09t52zix 399 24 et et FW cord-007788-09t52zix 399 25 al al NNP cord-007788-09t52zix 399 26 . . NNP cord-007788-09t52zix 399 27 2015 2015 CD cord-007788-09t52zix 399 28 ) ) -RRB- cord-007788-09t52zix 399 29 . . . cord-007788-09t52zix 400 1 As as IN cord-007788-09t52zix 400 2 mentioned mention VBN cord-007788-09t52zix 400 3 above above RB cord-007788-09t52zix 400 4 , , , cord-007788-09t52zix 400 5 the the DT cord-007788-09t52zix 400 6 risk risk NN cord-007788-09t52zix 400 7 factors factor NNS cord-007788-09t52zix 400 8 , , , cord-007788-09t52zix 400 9 as as RB cord-007788-09t52zix 400 10 well well RB cord-007788-09t52zix 400 11 as as IN cord-007788-09t52zix 400 12 the the DT cord-007788-09t52zix 400 13 clinical clinical JJ cord-007788-09t52zix 400 14 presentation presentation NN cord-007788-09t52zix 400 15 of of IN cord-007788-09t52zix 400 16 SOS SOS NNP cord-007788-09t52zix 400 17 / / SYM cord-007788-09t52zix 400 18 VOD VOD NNP cord-007788-09t52zix 400 19 , , , cord-007788-09t52zix 400 20 differ differ VBP cord-007788-09t52zix 400 21 between between IN cord-007788-09t52zix 400 22 the the DT cord-007788-09t52zix 400 23 adult adult NN cord-007788-09t52zix 400 24 and and CC cord-007788-09t52zix 400 25 the the DT cord-007788-09t52zix 400 26 paediatric paediatric JJ cord-007788-09t52zix 400 27 population population NN cord-007788-09t52zix 400 28 , , , cord-007788-09t52zix 400 29 and and CC cord-007788-09t52zix 400 30 the the DT cord-007788-09t52zix 400 31 risk risk NN cord-007788-09t52zix 400 32 factors factor NNS cord-007788-09t52zix 400 33 presented present VBN cord-007788-09t52zix 400 34 here here RB cord-007788-09t52zix 400 35 are be VBP cord-007788-09t52zix 400 36 related relate VBN cord-007788-09t52zix 400 37 to to IN cord-007788-09t52zix 400 38 adults adult NNS cord-007788-09t52zix 400 39 . . . cord-007788-09t52zix 401 1 The the DT cord-007788-09t52zix 401 2 patient patient NN cord-007788-09t52zix 401 3 - - HYPH cord-007788-09t52zix 401 4 and and CC cord-007788-09t52zix 401 5 disease disease NN cord-007788-09t52zix 401 6 - - HYPH cord-007788-09t52zix 401 7 related relate VBN cord-007788-09t52zix 401 8 risk risk NN cord-007788-09t52zix 401 9 factors factor NNS cord-007788-09t52zix 401 10 are be VBP cord-007788-09t52zix 401 11 : : : cord-007788-09t52zix 401 12 _SP cord-007788-09t52zix 401 13 Despite despite IN cord-007788-09t52zix 401 14 the the DT cord-007788-09t52zix 401 15 fact fact NN cord-007788-09t52zix 401 16 that that IN cord-007788-09t52zix 401 17 diagnostic diagnostic JJ cord-007788-09t52zix 401 18 criteria criterion NNS cord-007788-09t52zix 401 19 were be VBD cord-007788-09t52zix 401 20 developed develop VBN cord-007788-09t52zix 401 21 in in IN cord-007788-09t52zix 401 22 the the DT cord-007788-09t52zix 401 23 1980s 1980 NNS cord-007788-09t52zix 401 24 and and CC cord-007788-09t52zix 401 25 have have VBP cord-007788-09t52zix 401 26 been be VBN cord-007788-09t52zix 401 27 used use VBN cord-007788-09t52zix 401 28 in in IN cord-007788-09t52zix 401 29 clinical clinical JJ cord-007788-09t52zix 401 30 practice practice NN cord-007788-09t52zix 401 31 and and CC cord-007788-09t52zix 401 32 research research NN cord-007788-09t52zix 401 33 studies study NNS cord-007788-09t52zix 401 34 , , , cord-007788-09t52zix 401 35 it -PRON- PRP cord-007788-09t52zix 401 36 is be VBZ cord-007788-09t52zix 401 37 often often RB cord-007788-09t52zix 401 38 hard hard JJ cord-007788-09t52zix 401 39 to to TO cord-007788-09t52zix 401 40 identify identify VB cord-007788-09t52zix 401 41 early early JJ cord-007788-09t52zix 401 42 or or CC cord-007788-09t52zix 401 43 mild mild JJ cord-007788-09t52zix 401 44 cases case NNS cord-007788-09t52zix 401 45 of of IN cord-007788-09t52zix 401 46 SOS SOS NNP cord-007788-09t52zix 401 47 / / SYM cord-007788-09t52zix 401 48 VOD VOD NNP cord-007788-09t52zix 401 49 before before IN cord-007788-09t52zix 401 50 it -PRON- PRP cord-007788-09t52zix 401 51 progresses progress VBZ cord-007788-09t52zix 401 52 to to IN cord-007788-09t52zix 401 53 a a DT cord-007788-09t52zix 401 54 more more RBR cord-007788-09t52zix 401 55 severe severe JJ cord-007788-09t52zix 401 56 form form NN cord-007788-09t52zix 401 57 . . . cord-007788-09t52zix 402 1 Some some DT cord-007788-09t52zix 402 2 reasons reason NNS cord-007788-09t52zix 402 3 are be VBP cord-007788-09t52zix 402 4 lack lack NN cord-007788-09t52zix 402 5 of of IN cord-007788-09t52zix 402 6 sensitivity sensitivity NN cord-007788-09t52zix 402 7 and and CC cord-007788-09t52zix 402 8 specificity specificity NN cord-007788-09t52zix 402 9 of of IN cord-007788-09t52zix 402 10 the the DT cord-007788-09t52zix 402 11 criteria criterion NNS cord-007788-09t52zix 402 12 , , , cord-007788-09t52zix 402 13 the the DT cord-007788-09t52zix 402 14 dynamic dynamic JJ cord-007788-09t52zix 402 15 manifestations manifestation NNS cord-007788-09t52zix 402 16 that that WDT cord-007788-09t52zix 402 17 makes make VBZ cord-007788-09t52zix 402 18 definition definition NN cord-007788-09t52zix 402 19 of of IN cord-007788-09t52zix 402 20 the the DT cord-007788-09t52zix 402 21 condition condition NN cord-007788-09t52zix 402 22 hard hard RB cord-007788-09t52zix 402 23 and and CC cord-007788-09t52zix 402 24 that that IN cord-007788-09t52zix 402 25 early early JJ cord-007788-09t52zix 402 26 signs sign NNS cord-007788-09t52zix 402 27 and and CC cord-007788-09t52zix 402 28 symptoms symptom NNS cord-007788-09t52zix 402 29 often often RB cord-007788-09t52zix 402 30 are be VBP cord-007788-09t52zix 402 31 subtle subtle JJ cord-007788-09t52zix 402 32 and and CC cord-007788-09t52zix 402 33 makes make VBZ cord-007788-09t52zix 402 34 differentiation differentiation NN cord-007788-09t52zix 402 35 from from IN cord-007788-09t52zix 402 36 other other JJ cord-007788-09t52zix 402 37 transplant transplant NN cord-007788-09t52zix 402 38 complications complication NNS cord-007788-09t52zix 402 39 difficult difficult JJ cord-007788-09t52zix 402 40 . . . cord-007788-09t52zix 403 1 Given give VBN cord-007788-09t52zix 403 2 the the DT cord-007788-09t52zix 403 3 poor poor JJ cord-007788-09t52zix 403 4 prognosis prognosis NN cord-007788-09t52zix 403 5 of of IN cord-007788-09t52zix 403 6 severe severe JJ cord-007788-09t52zix 403 7 SOS SOS NNP cord-007788-09t52zix 403 8 / / SYM cord-007788-09t52zix 403 9 VOD VOD NNP cord-007788-09t52zix 403 10 , , , cord-007788-09t52zix 403 11 it -PRON- PRP cord-007788-09t52zix 403 12 is be VBZ cord-007788-09t52zix 403 13 however however RB cord-007788-09t52zix 403 14 vital vital JJ cord-007788-09t52zix 403 15 to to TO cord-007788-09t52zix 403 16 identify identify VB cord-007788-09t52zix 403 17 mild mild JJ cord-007788-09t52zix 403 18 cases case NNS cord-007788-09t52zix 403 19 before before IN cord-007788-09t52zix 403 20 they -PRON- PRP cord-007788-09t52zix 403 21 progress progress VBP cord-007788-09t52zix 403 22 to to TO cord-007788-09t52zix 403 23 moderate moderate VB cord-007788-09t52zix 403 24 , , , cord-007788-09t52zix 403 25 with with IN cord-007788-09t52zix 403 26 signs sign NNS cord-007788-09t52zix 403 27 of of IN cord-007788-09t52zix 403 28 hepatic hepatic JJ cord-007788-09t52zix 403 29 injury injury NN cord-007788-09t52zix 403 30 and and CC cord-007788-09t52zix 403 31 requiring require VBG cord-007788-09t52zix 403 32 more more RBR cord-007788-09t52zix 403 33 aggressive aggressive JJ cord-007788-09t52zix 403 34 intervention intervention NN cord-007788-09t52zix 403 35 , , , cord-007788-09t52zix 403 36 or or CC cord-007788-09t52zix 403 37 further further JJ cord-007788-09t52zix 403 38 progress progress NN cord-007788-09t52zix 403 39 to to IN cord-007788-09t52zix 403 40 severe severe JJ cord-007788-09t52zix 403 41 SOS SOS NNP cord-007788-09t52zix 403 42 / / SYM cord-007788-09t52zix 403 43 VOD VOD NNP cord-007788-09t52zix 403 44 with with IN cord-007788-09t52zix 403 45 MOD/ MOD/ NNP cord-007788-09t52zix 403 46 MOF MOF NNP cord-007788-09t52zix 403 47 . . . cord-007788-09t52zix 404 1 The the DT cord-007788-09t52zix 404 2 most most RBS cord-007788-09t52zix 404 3 recent recent JJ cord-007788-09t52zix 404 4 diagnostic diagnostic JJ cord-007788-09t52zix 404 5 criteria criterion NNS cord-007788-09t52zix 404 6 proposed propose VBN cord-007788-09t52zix 404 7 by by IN cord-007788-09t52zix 404 8 EBMT EBMT NNP cord-007788-09t52zix 405 1 ( ( -LRB- cord-007788-09t52zix 405 2 Mohty Mohty NNP cord-007788-09t52zix 405 3 et et FW cord-007788-09t52zix 405 4 al al NNP cord-007788-09t52zix 405 5 . . . cord-007788-09t52zix 405 6 2016 2016 CD cord-007788-09t52zix 405 7 ) ) -RRB- cord-007788-09t52zix 405 8 are be VBP cord-007788-09t52zix 405 9 the the DT cord-007788-09t52zix 405 10 same same JJ cord-007788-09t52zix 405 11 as as IN cord-007788-09t52zix 405 12 the the DT cord-007788-09t52zix 405 13 Baltimore Baltimore NNP cord-007788-09t52zix 405 14 criteria criterion NNS cord-007788-09t52zix 405 15 ( ( -LRB- cord-007788-09t52zix 405 16 Jones Jones NNP cord-007788-09t52zix 405 17 et et NNP cord-007788-09t52zix 405 18 al al NNP cord-007788-09t52zix 405 19 . . NNP cord-007788-09t52zix 405 20 1987 1987 CD cord-007788-09t52zix 405 21 ) ) -RRB- cord-007788-09t52zix 405 22 for for IN cord-007788-09t52zix 405 23 classical classical JJ cord-007788-09t52zix 405 24 SOS SOS NNP cord-007788-09t52zix 405 25 / / SYM cord-007788-09t52zix 405 26 VOD VOD NNP cord-007788-09t52zix 405 27 with with IN cord-007788-09t52zix 405 28 onset onset NN cord-007788-09t52zix 405 29 within within IN cord-007788-09t52zix 405 30 the the DT cord-007788-09t52zix 405 31 first first JJ cord-007788-09t52zix 405 32 3 3 CD cord-007788-09t52zix 405 33 weeks week NNS cord-007788-09t52zix 405 34 after after IN cord-007788-09t52zix 405 35 HSCT HSCT NNP cord-007788-09t52zix 405 36 , , , cord-007788-09t52zix 405 37 but but CC cord-007788-09t52zix 405 38 if if IN cord-007788-09t52zix 405 39 SOS SOS NNP cord-007788-09t52zix 405 40 / / SYM cord-007788-09t52zix 405 41 VOD VOD NNP cord-007788-09t52zix 405 42 develops develop VBZ cord-007788-09t52zix 405 43 after after IN cord-007788-09t52zix 405 44 day day NN cord-007788-09t52zix 405 45 +21 +21 CD cord-007788-09t52zix 405 46 , , , cord-007788-09t52zix 405 47 elevated elevated JJ cord-007788-09t52zix 405 48 serum serum NN cord-007788-09t52zix 405 49 bilirubin bilirubin NN cord-007788-09t52zix 405 50 level level NN cord-007788-09t52zix 405 51 is be VBZ cord-007788-09t52zix 405 52 not not RB cord-007788-09t52zix 405 53 always always RB cord-007788-09t52zix 405 54 seen see VBN cord-007788-09t52zix 405 55 , , , cord-007788-09t52zix 405 56 why why WRB cord-007788-09t52zix 405 57 a a DT cord-007788-09t52zix 405 58 modified modify VBN cord-007788-09t52zix 405 59 version version NN cord-007788-09t52zix 405 60 of of IN cord-007788-09t52zix 405 61 the the DT cord-007788-09t52zix 405 62 criteria criterion NNS cord-007788-09t52zix 405 63 can can MD cord-007788-09t52zix 405 64 be be VB cord-007788-09t52zix 405 65 used use VBN cord-007788-09t52zix 405 66 for for IN cord-007788-09t52zix 405 67 diagnosis diagnosis NN cord-007788-09t52zix 405 68 of of IN cord-007788-09t52zix 405 69 late late JJ cord-007788-09t52zix 405 70 SOS SOS NNP cord-007788-09t52zix 405 71 / / SYM cord-007788-09t52zix 405 72 VOD VOD NNP cord-007788-09t52zix 405 73 ( ( -LRB- cord-007788-09t52zix 405 74 Mohty Mohty NNP cord-007788-09t52zix 405 75 et et FW cord-007788-09t52zix 405 76 al al NNP cord-007788-09t52zix 405 77 . . . cord-007788-09t52zix 405 78 2016 2016 CD cord-007788-09t52zix 405 79 ) ) -RRB- cord-007788-09t52zix 406 1 ( ( -LRB- cord-007788-09t52zix 406 2 Table table NN cord-007788-09t52zix 406 3 9 9 CD cord-007788-09t52zix 406 4 .4 .4 CD cord-007788-09t52zix 406 5 ) ) -RRB- cord-007788-09t52zix 406 6 . . . cord-007788-09t52zix 407 1 The the DT cord-007788-09t52zix 407 2 EBMT EBMT NNP cord-007788-09t52zix 407 3 criteria criterion NNS cord-007788-09t52zix 407 4 will will MD cord-007788-09t52zix 407 5 also also RB cord-007788-09t52zix 407 6 better well RBR cord-007788-09t52zix 407 7 capture capture VB cord-007788-09t52zix 407 8 the the DT cord-007788-09t52zix 407 9 dynamic dynamic JJ cord-007788-09t52zix 407 10 manifestations manifestation NNS cord-007788-09t52zix 407 11 of of IN cord-007788-09t52zix 407 12 the the DT cord-007788-09t52zix 407 13 disease disease NN cord-007788-09t52zix 407 14 and and CC cord-007788-09t52zix 407 15 thus thus RB cord-007788-09t52zix 407 16 facilitate facilitate VB cord-007788-09t52zix 407 17 an an DT cord-007788-09t52zix 407 18 early early JJ cord-007788-09t52zix 407 19 diagnosis diagnosis NN cord-007788-09t52zix 407 20 as as RB cord-007788-09t52zix 407 21 well well RB cord-007788-09t52zix 407 22 as as IN cord-007788-09t52zix 407 23 a a DT cord-007788-09t52zix 407 24 more more RBR cord-007788-09t52zix 407 25 accurate accurate JJ cord-007788-09t52zix 407 26 assessment assessment NN cord-007788-09t52zix 407 27 of of IN cord-007788-09t52zix 407 28 severity severity NN cord-007788-09t52zix 407 29 . . . cord-007788-09t52zix 408 1 Treatment treatment NN cord-007788-09t52zix 408 2 can can MD cord-007788-09t52zix 408 3 then then RB cord-007788-09t52zix 408 4 be be VB cord-007788-09t52zix 408 5 started start VBN cord-007788-09t52zix 408 6 at at IN cord-007788-09t52zix 408 7 a a DT cord-007788-09t52zix 408 8 stage stage NN cord-007788-09t52zix 408 9 with with IN cord-007788-09t52zix 408 10 greater great JJR cord-007788-09t52zix 408 11 chance chance NN cord-007788-09t52zix 408 12 for for IN cord-007788-09t52zix 408 13 treatment treatment NN cord-007788-09t52zix 408 14 response response NN cord-007788-09t52zix 408 15 . . . cord-007788-09t52zix 409 1 Differential differential JJ cord-007788-09t52zix 409 2 diagnoses diagnosis NNS cord-007788-09t52zix 409 3 will will MD cord-007788-09t52zix 409 4 need need VB cord-007788-09t52zix 409 5 to to TO cord-007788-09t52zix 409 6 be be VB cord-007788-09t52zix 409 7 excluded exclude VBN cord-007788-09t52zix 409 8 by by IN cord-007788-09t52zix 409 9 assessing assess VBG cord-007788-09t52zix 409 10 risk risk NN cord-007788-09t52zix 409 11 factors factor NNS cord-007788-09t52zix 409 12 , , , cord-007788-09t52zix 409 13 symptoms symptom NNS cord-007788-09t52zix 409 14 and and CC cord-007788-09t52zix 409 15 lab lab NN cord-007788-09t52zix 409 16 tests test NNS cord-007788-09t52zix 409 17 since since IN cord-007788-09t52zix 409 18 liver liver NN cord-007788-09t52zix 409 19 dysfunction dysfunction NN cord-007788-09t52zix 409 20 can can MD cord-007788-09t52zix 409 21 also also RB cord-007788-09t52zix 409 22 be be VB cord-007788-09t52zix 409 23 seen see VBN cord-007788-09t52zix 409 24 in in IN cord-007788-09t52zix 409 25 sepsis sepsis NN cord-007788-09t52zix 409 26 , , , cord-007788-09t52zix 409 27 viral viral JJ cord-007788-09t52zix 409 28 infection infection NN cord-007788-09t52zix 409 29 , , , cord-007788-09t52zix 409 30 graft graft NN cord-007788-09t52zix 409 31 versus versus IN cord-007788-09t52zix 409 32 host host NN cord-007788-09t52zix 409 33 disease disease NN cord-007788-09t52zix 409 34 ( ( -LRB- cord-007788-09t52zix 409 35 GvHD GvHD NNP cord-007788-09t52zix 409 36 ) ) -RRB- cord-007788-09t52zix 409 37 and and CC cord-007788-09t52zix 409 38 iron iron NN cord-007788-09t52zix 409 39 overload overload NN cord-007788-09t52zix 409 40 and and CC cord-007788-09t52zix 409 41 as as IN cord-007788-09t52zix 409 42 a a DT cord-007788-09t52zix 409 43 side side NN cord-007788-09t52zix 409 44 effect effect NN cord-007788-09t52zix 409 45 from from IN cord-007788-09t52zix 409 46 many many JJ cord-007788-09t52zix 409 47 of of IN cord-007788-09t52zix 409 48 the the DT cord-007788-09t52zix 409 49 drugs drug NNS cord-007788-09t52zix 409 50 used use VBN cord-007788-09t52zix 409 51 in in IN cord-007788-09t52zix 409 52 the the DT cord-007788-09t52zix 409 53 HSCT HSCT NNP cord-007788-09t52zix 409 54 setting setting NN cord-007788-09t52zix 409 55 . . . cord-007788-09t52zix 410 1 In in IN cord-007788-09t52zix 410 2 addition addition NN cord-007788-09t52zix 410 3 to to IN cord-007788-09t52zix 410 4 the the DT cord-007788-09t52zix 410 5 signs sign NNS cord-007788-09t52zix 410 6 and and CC cord-007788-09t52zix 410 7 symptoms symptom NNS cord-007788-09t52zix 410 8 required require VBN cord-007788-09t52zix 410 9 for for IN cord-007788-09t52zix 410 10 diagnosis diagnosis NN cord-007788-09t52zix 410 11 haemorrhagic haemorrhagic JJ cord-007788-09t52zix 410 12 complications complication NNS cord-007788-09t52zix 410 13 , , , cord-007788-09t52zix 410 14 thrombocytopenia thrombocytopenia NN cord-007788-09t52zix 410 15 with with IN cord-007788-09t52zix 410 16 platelet platelet NN cord-007788-09t52zix 410 17 refractoriness refractoriness NN cord-007788-09t52zix 410 18 , , , cord-007788-09t52zix 410 19 pulmonary pulmonary JJ cord-007788-09t52zix 410 20 dysfunction dysfunction NN cord-007788-09t52zix 410 21 , , , cord-007788-09t52zix 410 22 renal renal JJ cord-007788-09t52zix 410 23 dysfunction dysfunction NN cord-007788-09t52zix 410 24 and and CC cord-007788-09t52zix 410 25 encephalopathy encephalopathy NN cord-007788-09t52zix 410 26 are be VBP cord-007788-09t52zix 410 27 " " `` cord-007788-09t52zix 410 28 late late JJ cord-007788-09t52zix 410 29 " " '' cord-007788-09t52zix 410 30 signs sign NNS cord-007788-09t52zix 410 31 that that WDT cord-007788-09t52zix 410 32 can can MD cord-007788-09t52zix 410 33 be be VB cord-007788-09t52zix 410 34 seen see VBN cord-007788-09t52zix 410 35 in in IN cord-007788-09t52zix 410 36 more more JJR cord-007788-09t52zix 410 37 severe severe JJ cord-007788-09t52zix 410 38 cases case NNS cord-007788-09t52zix 410 39 of of IN cord-007788-09t52zix 410 40 SOS SOS NNP cord-007788-09t52zix 410 41 / / SYM cord-007788-09t52zix 410 42 VOD VOD NNP cord-007788-09t52zix 410 43 . . . cord-007788-09t52zix 411 1 Further further RB cord-007788-09t52zix 411 2 it -PRON- PRP cord-007788-09t52zix 411 3 is be VBZ cord-007788-09t52zix 411 4 worth worth JJ cord-007788-09t52zix 411 5 noting note VBG cord-007788-09t52zix 411 6 that that IN cord-007788-09t52zix 411 7 all all DT cord-007788-09t52zix 411 8 symptoms symptom NNS cord-007788-09t52zix 411 9 are be VBP cord-007788-09t52zix 411 10 also also RB cord-007788-09t52zix 411 11 observed observe VBN cord-007788-09t52zix 411 12 in in IN cord-007788-09t52zix 411 13 other other JJ cord-007788-09t52zix 411 14 conditions condition NNS cord-007788-09t52zix 411 15 and and CC cord-007788-09t52zix 411 16 that that IN cord-007788-09t52zix 411 17 many many JJ cord-007788-09t52zix 411 18 other other JJ cord-007788-09t52zix 411 19 complications complication NNS cord-007788-09t52zix 411 20 may may MD cord-007788-09t52zix 411 21 coexist coexist VB cord-007788-09t52zix 411 22 with with IN cord-007788-09t52zix 411 23 SOS SOS NNP cord-007788-09t52zix 411 24 / / SYM cord-007788-09t52zix 411 25 VOD VOD NNP cord-007788-09t52zix 411 26 . . . cord-007788-09t52zix 412 1 Examples example NNS cord-007788-09t52zix 412 2 of of IN cord-007788-09t52zix 412 3 differential differential JJ cord-007788-09t52zix 412 4 diagnosis diagnosis NN cord-007788-09t52zix 412 5 for for IN cord-007788-09t52zix 412 6 classical classical JJ cord-007788-09t52zix 412 7 symptoms symptom NNS cord-007788-09t52zix 412 8 of of IN cord-007788-09t52zix 412 9 SOS SOS NNP cord-007788-09t52zix 412 10 / / SYM cord-007788-09t52zix 412 11 VOD VOD NNP cord-007788-09t52zix 412 12 are be VBP cord-007788-09t52zix 412 13 listed list VBN cord-007788-09t52zix 412 14 in in IN cord-007788-09t52zix 412 15 Table Table NNP cord-007788-09t52zix 412 16 9 9 CD cord-007788-09t52zix 412 17 .5 .5 CD cord-007788-09t52zix 412 18 . . . cord-007788-09t52zix 413 1 When when WRB cord-007788-09t52zix 413 2 SOS SOS NNP cord-007788-09t52zix 413 3 / / SYM cord-007788-09t52zix 413 4 VOD VOD NNP cord-007788-09t52zix 413 5 is be VBZ cord-007788-09t52zix 413 6 diagnosed diagnose VBN cord-007788-09t52zix 413 7 , , , cord-007788-09t52zix 413 8 it -PRON- PRP cord-007788-09t52zix 413 9 is be VBZ cord-007788-09t52zix 413 10 important important JJ cord-007788-09t52zix 413 11 to to TO cord-007788-09t52zix 413 12 classify classify VB cord-007788-09t52zix 413 13 the the DT cord-007788-09t52zix 413 14 severity severity NN cord-007788-09t52zix 413 15 grade grade NN cord-007788-09t52zix 413 16 in in IN cord-007788-09t52zix 413 17 order order NN cord-007788-09t52zix 413 18 to to TO cord-007788-09t52zix 413 19 intensify intensify VB cord-007788-09t52zix 413 20 the the DT cord-007788-09t52zix 413 21 monitoring monitoring NN cord-007788-09t52zix 413 22 and and CC cord-007788-09t52zix 413 23 identify identify VB cord-007788-09t52zix 413 24 patients patient NNS cord-007788-09t52zix 413 25 that that WDT cord-007788-09t52zix 413 26 will will MD cord-007788-09t52zix 413 27 need need VB cord-007788-09t52zix 413 28 therapeutic therapeutic JJ cord-007788-09t52zix 413 29 intervention intervention NN cord-007788-09t52zix 413 30 . . . cord-007788-09t52zix 414 1 The the DT cord-007788-09t52zix 414 2 EBMT EBMT NNP cord-007788-09t52zix 414 3 severity severity NN cord-007788-09t52zix 414 4 grading grading NN cord-007788-09t52zix 414 5 criteria criterion NNS cord-007788-09t52zix 414 6 ( ( -LRB- cord-007788-09t52zix 414 7 Mohty Mohty NNP cord-007788-09t52zix 414 8 et et FW cord-007788-09t52zix 414 9 al al NNP cord-007788-09t52zix 414 10 . . . cord-007788-09t52zix 414 11 2016 2016 CD cord-007788-09t52zix 414 12 ) ) -RRB- cord-007788-09t52zix 414 13 stress stress VBP cord-007788-09t52zix 414 14 the the DT cord-007788-09t52zix 414 15 importance importance NN cord-007788-09t52zix 414 16 of of IN cord-007788-09t52zix 414 17 taking take VBG cord-007788-09t52zix 414 18 the the DT cord-007788-09t52zix 414 19 time time NN cord-007788-09t52zix 414 20 since since IN cord-007788-09t52zix 414 21 the the DT cord-007788-09t52zix 414 22 appearance appearance NN cord-007788-09t52zix 414 23 of of IN cord-007788-09t52zix 414 24 the the DT cord-007788-09t52zix 414 25 symptoms symptom NNS cord-007788-09t52zix 414 26 into into IN cord-007788-09t52zix 414 27 account account NN cord-007788-09t52zix 414 28 . . . cord-007788-09t52zix 415 1 A a DT cord-007788-09t52zix 415 2 rapid rapid JJ cord-007788-09t52zix 415 3 progression progression NN cord-007788-09t52zix 415 4 of of IN cord-007788-09t52zix 415 5 symptoms symptom NNS cord-007788-09t52zix 415 6 , , , cord-007788-09t52zix 415 7 and and CC cord-007788-09t52zix 415 8 in in IN cord-007788-09t52zix 415 9 particular particular JJ cord-007788-09t52zix 415 10 bilirubin bilirubin NN cord-007788-09t52zix 415 11 kinetics kinetic NNS cord-007788-09t52zix 415 12 ( ( -LRB- cord-007788-09t52zix 415 13 the the DT cord-007788-09t52zix 415 14 rate rate NN cord-007788-09t52zix 415 15 of of IN cord-007788-09t52zix 415 16 increase increase NN cord-007788-09t52zix 415 17 ) ) -RRB- cord-007788-09t52zix 415 18 with with IN cord-007788-09t52zix 415 19 a a DT cord-007788-09t52zix 415 20 doubling double VBG cord-007788-09t52zix 415 21 time time NN cord-007788-09t52zix 415 22 of of IN cord-007788-09t52zix 415 23 48 48 CD cord-007788-09t52zix 415 24 h h NN cord-007788-09t52zix 415 25 , , , cord-007788-09t52zix 415 26 should should MD cord-007788-09t52zix 415 27 be be VB cord-007788-09t52zix 415 28 classified classify VBN cord-007788-09t52zix 415 29 as as IN cord-007788-09t52zix 415 30 a a DT cord-007788-09t52zix 415 31 more more RBR cord-007788-09t52zix 415 32 severe severe JJ cord-007788-09t52zix 415 33 grade grade NN cord-007788-09t52zix 415 34 than than IN cord-007788-09t52zix 415 35 if if IN cord-007788-09t52zix 415 36 symptoms symptom NNS cord-007788-09t52zix 415 37 develop develop VBP cord-007788-09t52zix 415 38 more more RBR cord-007788-09t52zix 415 39 slowly slowly RB cord-007788-09t52zix 415 40 over over IN cord-007788-09t52zix 415 41 several several JJ cord-007788-09t52zix 415 42 days day NNS cord-007788-09t52zix 415 43 ( ( -LRB- cord-007788-09t52zix 415 44 Table table NN cord-007788-09t52zix 415 45 9 9 CD cord-007788-09t52zix 415 46 .6 .6 CD cord-007788-09t52zix 415 47 ) ) -RRB- cord-007788-09t52zix 415 48 . . . cord-007788-09t52zix 416 1 The the DT cord-007788-09t52zix 416 2 first first JJ cord-007788-09t52zix 416 3 strategy strategy NN cord-007788-09t52zix 416 4 for for IN cord-007788-09t52zix 416 5 prevention prevention NN cord-007788-09t52zix 416 6 is be VBZ cord-007788-09t52zix 416 7 to to TO cord-007788-09t52zix 416 8 be be VB cord-007788-09t52zix 416 9 aware aware JJ cord-007788-09t52zix 416 10 of of IN cord-007788-09t52zix 416 11 pre pre JJ cord-007788-09t52zix 416 12 - - JJ cord-007788-09t52zix 416 13 existing existing JJ cord-007788-09t52zix 416 14 risk risk NN cord-007788-09t52zix 416 15 factors factor NNS cord-007788-09t52zix 416 16 and and CC cord-007788-09t52zix 416 17 try try VB cord-007788-09t52zix 416 18 and and CC cord-007788-09t52zix 416 19 eliminate eliminate VB cord-007788-09t52zix 416 20 them -PRON- PRP cord-007788-09t52zix 416 21 as as RB cord-007788-09t52zix 416 22 far far RB cord-007788-09t52zix 416 23 as as IN cord-007788-09t52zix 416 24 possible possible JJ cord-007788-09t52zix 416 25 and and CC cord-007788-09t52zix 416 26 potentially potentially RB cord-007788-09t52zix 416 27 establish establish VB cord-007788-09t52zix 416 28 supportive supportive JJ cord-007788-09t52zix 416 29 or or CC cord-007788-09t52zix 416 30 treatment treatment NN cord-007788-09t52zix 416 31 measures measure NNS cord-007788-09t52zix 416 32 prior prior RB cord-007788-09t52zix 416 33 to to IN cord-007788-09t52zix 416 34 transplant transplant NN cord-007788-09t52zix 416 35 . . . cord-007788-09t52zix 417 1 The the DT cord-007788-09t52zix 417 2 patient patient NN cord-007788-09t52zix 417 3 - - HYPH cord-007788-09t52zix 417 4 and and CC cord-007788-09t52zix 417 5 disease disease NN cord-007788-09t52zix 417 6 - - HYPH cord-007788-09t52zix 417 7 related relate VBN cord-007788-09t52zix 417 8 risk risk NN cord-007788-09t52zix 417 9 factors factor NNS cord-007788-09t52zix 417 10 , , , cord-007788-09t52zix 417 11 including include VBG cord-007788-09t52zix 417 12 hepatic hepatic JJ cord-007788-09t52zix 417 13 , , , cord-007788-09t52zix 417 14 are be VBP cord-007788-09t52zix 417 15 often often RB cord-007788-09t52zix 417 16 difficult difficult JJ cord-007788-09t52zix 417 17 or or CC cord-007788-09t52zix 417 18 impossible impossible JJ cord-007788-09t52zix 417 19 to to TO cord-007788-09t52zix 417 20 change change VB cord-007788-09t52zix 417 21 , , , cord-007788-09t52zix 417 22 but but CC cord-007788-09t52zix 417 23 the the DT cord-007788-09t52zix 417 24 transplant transplant NN cord-007788-09t52zix 417 25 - - HYPH cord-007788-09t52zix 417 26 related relate VBN cord-007788-09t52zix 417 27 risk risk NN cord-007788-09t52zix 417 28 factors factor NNS cord-007788-09t52zix 417 29 should should MD cord-007788-09t52zix 417 30 be be VB cord-007788-09t52zix 417 31 carefully carefully RB cord-007788-09t52zix 417 32 considered consider VBN cord-007788-09t52zix 417 33 in in IN cord-007788-09t52zix 417 34 the the DT cord-007788-09t52zix 417 35 pre pre JJ cord-007788-09t52zix 417 36 - - JJ cord-007788-09t52zix 417 37 transplant transplant JJ cord-007788-09t52zix 417 38 setting setting NN cord-007788-09t52zix 417 39 . . . cord-007788-09t52zix 418 1 No no DT cord-007788-09t52zix 418 2 proven prove VBN cord-007788-09t52zix 418 3 medical medical JJ cord-007788-09t52zix 418 4 prophylaxis prophylaxis NN cord-007788-09t52zix 418 5 exists exist VBZ cord-007788-09t52zix 418 6 but but CC cord-007788-09t52zix 418 7 sodium sodium NN cord-007788-09t52zix 418 8 heparin heparin NN cord-007788-09t52zix 418 9 , , , cord-007788-09t52zix 418 10 prostaglandin prostaglandin NN cord-007788-09t52zix 418 11 E1 e1 NN cord-007788-09t52zix 418 12 , , , cord-007788-09t52zix 418 13 ursodeoxycholic ursodeoxycholic JJ cord-007788-09t52zix 418 14 acid acid NN cord-007788-09t52zix 418 15 and and CC cord-007788-09t52zix 418 16 low low JJ cord-007788-09t52zix 418 17 molecular molecular JJ cord-007788-09t52zix 418 18 weight weight NN cord-007788-09t52zix 418 19 heparin heparin NN cord-007788-09t52zix 418 20 have have VBP cord-007788-09t52zix 418 21 Jones Jones NNP cord-007788-09t52zix 418 22 et et NNP cord-007788-09t52zix 418 23 al al NNP cord-007788-09t52zix 418 24 . . . cord-007788-09t52zix 419 1 ( ( -LRB- cord-007788-09t52zix 419 2 1987 1987 CD cord-007788-09t52zix 419 3 ) ) -RRB- cord-007788-09t52zix 419 4 been be VBN cord-007788-09t52zix 419 5 tried try VBN cord-007788-09t52zix 419 6 , , , cord-007788-09t52zix 419 7 although although IN cord-007788-09t52zix 419 8 data datum NNS cord-007788-09t52zix 419 9 about about IN cord-007788-09t52zix 419 10 effectiveness effectiveness NN cord-007788-09t52zix 419 11 remains remain VBZ cord-007788-09t52zix 419 12 inconclusive inconclusive JJ cord-007788-09t52zix 419 13 ( ( -LRB- cord-007788-09t52zix 419 14 Carreras Carreras NNP cord-007788-09t52zix 419 15 2012 2012 CD cord-007788-09t52zix 419 16 ( ( -LRB- cord-007788-09t52zix 419 17 Carreras Carreras NNP cord-007788-09t52zix 419 18 , , , cord-007788-09t52zix 419 19 2015 2015 CD cord-007788-09t52zix 419 20 . . . cord-007788-09t52zix 420 1 Defibrotide Defibrotide NNP cord-007788-09t52zix 420 2 , , , cord-007788-09t52zix 420 3 approved approve VBN cord-007788-09t52zix 420 4 for for IN cord-007788-09t52zix 420 5 treatment treatment NN cord-007788-09t52zix 420 6 of of IN cord-007788-09t52zix 420 7 severe severe JJ cord-007788-09t52zix 420 8 SOS SOS NNP cord-007788-09t52zix 420 9 / / SYM cord-007788-09t52zix 420 10 VOD VOD NNP cord-007788-09t52zix 420 11 , , , cord-007788-09t52zix 420 12 has have VBZ cord-007788-09t52zix 420 13 also also RB cord-007788-09t52zix 420 14 been be VBN cord-007788-09t52zix 420 15 used use VBN cord-007788-09t52zix 420 16 as as IN cord-007788-09t52zix 420 17 prophylaxis prophylaxis NN cord-007788-09t52zix 420 18 ( ( -LRB- cord-007788-09t52zix 420 19 Dignan Dignan NNP cord-007788-09t52zix 420 20 et et NNP cord-007788-09t52zix 420 21 al al NNP cord-007788-09t52zix 420 22 . . NNP cord-007788-09t52zix 420 23 2013 2013 CD cord-007788-09t52zix 420 24 ) ) -RRB- cord-007788-09t52zix 420 25 , , , cord-007788-09t52zix 420 26 and and CC cord-007788-09t52zix 420 27 one one CD cord-007788-09t52zix 420 28 randomised randomised JJ cord-007788-09t52zix 420 29 study study NN cord-007788-09t52zix 420 30 in in IN cord-007788-09t52zix 420 31 children child NNS cord-007788-09t52zix 420 32 has have VBZ cord-007788-09t52zix 420 33 shown show VBN cord-007788-09t52zix 420 34 a a DT cord-007788-09t52zix 420 35 reduction reduction NN cord-007788-09t52zix 420 36 in in IN cord-007788-09t52zix 420 37 SOS SOS NNP cord-007788-09t52zix 420 38 / / SYM cord-007788-09t52zix 420 39 VOD VOD NNP cord-007788-09t52zix 420 40 incidence incidence NN cord-007788-09t52zix 421 1 ( ( -LRB- cord-007788-09t52zix 421 2 Corbacioglu Corbacioglu NNP cord-007788-09t52zix 421 3 et et NNP cord-007788-09t52zix 421 4 al al NNP cord-007788-09t52zix 421 5 . . NNP cord-007788-09t52zix 421 6 2012 2012 CD cord-007788-09t52zix 421 7 ) ) -RRB- cord-007788-09t52zix 421 8 . . . cord-007788-09t52zix 422 1 As as RB cord-007788-09t52zix 422 2 soon soon RB cord-007788-09t52zix 422 3 as as IN cord-007788-09t52zix 422 4 SOS SOS NNP cord-007788-09t52zix 422 5 / / SYM cord-007788-09t52zix 422 6 VOD VOD NNP cord-007788-09t52zix 422 7 is be VBZ cord-007788-09t52zix 422 8 suspected suspect VBN cord-007788-09t52zix 422 9 , , , cord-007788-09t52zix 422 10 supportive supportive JJ cord-007788-09t52zix 422 11 therapy therapy NN cord-007788-09t52zix 422 12 should should MD cord-007788-09t52zix 422 13 be be VB cord-007788-09t52zix 422 14 initiated initiate VBN cord-007788-09t52zix 422 15 . . . cord-007788-09t52zix 423 1 In in IN cord-007788-09t52zix 423 2 mild mild JJ cord-007788-09t52zix 423 3 cases case NNS cord-007788-09t52zix 423 4 of of IN cord-007788-09t52zix 423 5 SOS/ SOS/ NNP cord-007788-09t52zix 423 6 VOD VOD NNP cord-007788-09t52zix 423 7 , , , cord-007788-09t52zix 423 8 close close JJ cord-007788-09t52zix 423 9 monitoring monitoring NN cord-007788-09t52zix 423 10 to to TO cord-007788-09t52zix 423 11 detect detect VB cord-007788-09t52zix 423 12 progression progression NN cord-007788-09t52zix 423 13 and and CC cord-007788-09t52zix 423 14 supportive supportive JJ cord-007788-09t52zix 423 15 management management NN cord-007788-09t52zix 423 16 is be VBZ cord-007788-09t52zix 423 17 often often RB cord-007788-09t52zix 423 18 sufficient sufficient JJ cord-007788-09t52zix 423 19 . . . cord-007788-09t52zix 424 1 The the DT cord-007788-09t52zix 424 2 monitoring monitoring NN cord-007788-09t52zix 424 3 should should MD cord-007788-09t52zix 424 4 include include VB cord-007788-09t52zix 424 5 : : : cord-007788-09t52zix 425 1 For for IN cord-007788-09t52zix 425 2 more more JJR cord-007788-09t52zix 425 3 details detail NNS cord-007788-09t52zix 425 4 about about IN cord-007788-09t52zix 425 5 nursing nursing NN cord-007788-09t52zix 425 6 interventions intervention NNS cord-007788-09t52zix 425 7 see see VBP cord-007788-09t52zix 425 8 below below RB cord-007788-09t52zix 425 9 . . . cord-007788-09t52zix 426 1 The the DT cord-007788-09t52zix 426 2 only only JJ cord-007788-09t52zix 426 3 curative curative JJ cord-007788-09t52zix 426 4 treatment treatment NN cord-007788-09t52zix 426 5 for for IN cord-007788-09t52zix 426 6 SOS SOS NNP cord-007788-09t52zix 426 7 / / SYM cord-007788-09t52zix 426 8 VOD VOD NNP cord-007788-09t52zix 426 9 is be VBZ cord-007788-09t52zix 426 10 the the DT cord-007788-09t52zix 426 11 drug drug NN cord-007788-09t52zix 426 12 defibrotide defibrotide NN cord-007788-09t52zix 426 13 . . . cord-007788-09t52zix 427 1 Defibrotide Defibrotide NNP cord-007788-09t52zix 427 2 protects protect VBZ cord-007788-09t52zix 427 3 the the DT cord-007788-09t52zix 427 4 endothelial endothelial JJ cord-007788-09t52zix 427 5 cells cell NNS cord-007788-09t52zix 427 6 , , , cord-007788-09t52zix 427 7 reduces reduce VBZ cord-007788-09t52zix 427 8 inflammation inflammation NN cord-007788-09t52zix 427 9 and and CC cord-007788-09t52zix 427 10 restores restore VBZ cord-007788-09t52zix 427 11 thrombo thrombo NN cord-007788-09t52zix 427 12 - - HYPH cord-007788-09t52zix 427 13 fibrinolytic fibrinolytic NN cord-007788-09t52zix 427 14 balance balance NN cord-007788-09t52zix 428 1 ( ( -LRB- cord-007788-09t52zix 428 2 Richardson Richardson NNP cord-007788-09t52zix 428 3 et et NNP cord-007788-09t52zix 428 4 al al NNP cord-007788-09t52zix 428 5 . . NNP cord-007788-09t52zix 428 6 2013 2013 CD cord-007788-09t52zix 428 7 ) ) -RRB- cord-007788-09t52zix 428 8 . . . cord-007788-09t52zix 429 1 The the DT cord-007788-09t52zix 429 2 recommended recommend VBN cord-007788-09t52zix 429 3 dose dose NN cord-007788-09t52zix 429 4 is be VBZ cord-007788-09t52zix 429 5 6.25 6.25 CD cord-007788-09t52zix 429 6 mg mg NNP cord-007788-09t52zix 429 7 / / SYM cord-007788-09t52zix 429 8 kg kg NN cord-007788-09t52zix 429 9 body body NN cord-007788-09t52zix 429 10 weight weight NN cord-007788-09t52zix 429 11 administered administer VBN cord-007788-09t52zix 429 12 as as IN cord-007788-09t52zix 429 13 a a DT cord-007788-09t52zix 429 14 2-h 2-h CD cord-007788-09t52zix 429 15 , , , cord-007788-09t52zix 429 16 i.v i.v NNP cord-007788-09t52zix 429 17 . . . cord-007788-09t52zix 429 18 infusion infusion NN cord-007788-09t52zix 429 19 every every DT cord-007788-09t52zix 429 20 6 6 CD cord-007788-09t52zix 429 21 h h NN cord-007788-09t52zix 429 22 ( ( -LRB- cord-007788-09t52zix 429 23 to to IN cord-007788-09t52zix 429 24 a a DT cord-007788-09t52zix 429 25 total total JJ cord-007788-09t52zix 429 26 dose dose NN cord-007788-09t52zix 429 27 of of IN cord-007788-09t52zix 429 28 25 25 CD cord-007788-09t52zix 429 29 mg mg NNP cord-007788-09t52zix 429 30 / / SYM cord-007788-09t52zix 429 31 kg kg NNP cord-007788-09t52zix 429 32 / / SYM cord-007788-09t52zix 429 33 day day NN cord-007788-09t52zix 429 34 ) ) -RRB- cord-007788-09t52zix 429 35 . . . cord-007788-09t52zix 430 1 Recommendation recommendation NN cord-007788-09t52zix 430 2 for for IN cord-007788-09t52zix 430 3 treatment treatment NN cord-007788-09t52zix 430 4 duration duration NN cord-007788-09t52zix 430 5 is be VBZ cord-007788-09t52zix 430 6 at at IN cord-007788-09t52zix 430 7 least least RBS cord-007788-09t52zix 430 8 21 21 CD cord-007788-09t52zix 430 9 days day NNS cord-007788-09t52zix 430 10 but but CC cord-007788-09t52zix 430 11 should should MD cord-007788-09t52zix 430 12 continue continue VB cord-007788-09t52zix 430 13 until until IN cord-007788-09t52zix 430 14 the the DT cord-007788-09t52zix 430 15 symptoms symptom NNS cord-007788-09t52zix 430 16 and and CC cord-007788-09t52zix 430 17 signs sign NNS cord-007788-09t52zix 430 18 of of IN cord-007788-09t52zix 430 19 severe severe JJ cord-007788-09t52zix 430 20 VOD vod NN cord-007788-09t52zix 430 21 resolve resolve NN cord-007788-09t52zix 430 22 . . . cord-007788-09t52zix 431 1 Defibrotide Defibrotide NNP cord-007788-09t52zix 431 2 is be VBZ cord-007788-09t52zix 431 3 generally generally RB cord-007788-09t52zix 431 4 well well RB cord-007788-09t52zix 431 5 tolerated tolerate VBN cord-007788-09t52zix 431 6 ( ( -LRB- cord-007788-09t52zix 431 7 Keating Keating NNP cord-007788-09t52zix 431 8 2014 2014 CD cord-007788-09t52zix 431 9 ) ) -RRB- cord-007788-09t52zix 431 10 but but CC cord-007788-09t52zix 431 11 should should MD cord-007788-09t52zix 431 12 not not RB cord-007788-09t52zix 431 13 be be VB cord-007788-09t52zix 431 14 used use VBN cord-007788-09t52zix 431 15 with with IN cord-007788-09t52zix 431 16 products product NNS cord-007788-09t52zix 431 17 that that WDT cord-007788-09t52zix 431 18 affect affect VBP cord-007788-09t52zix 431 19 platelet platelet NN cord-007788-09t52zix 431 20 aggregation aggregation NN cord-007788-09t52zix 431 21 , , , cord-007788-09t52zix 431 22 e.g. e.g. IN cord-007788-09t52zix 431 23 nonsteroid nonsteroid JJ cord-007788-09t52zix 431 24 anti anti JJ cord-007788-09t52zix 431 25 - - JJ cord-007788-09t52zix 431 26 inflammatory inflammatory JJ cord-007788-09t52zix 431 27 drugs drug NNS cord-007788-09t52zix 431 28 ( ( -LRB- cord-007788-09t52zix 431 29 NSAIDs NSAIDs NNP cord-007788-09t52zix 431 30 ) ) -RRB- cord-007788-09t52zix 431 31 , , , cord-007788-09t52zix 431 32 anticoagulant anticoagulant JJ cord-007788-09t52zix 431 33 therapy therapy NN cord-007788-09t52zix 431 34 or or CC cord-007788-09t52zix 431 35 other other JJ cord-007788-09t52zix 431 36 products product NNS cord-007788-09t52zix 431 37 that that WDT cord-007788-09t52zix 431 38 increase increase VBP cord-007788-09t52zix 431 39 the the DT cord-007788-09t52zix 431 40 risk risk NN cord-007788-09t52zix 431 41 of of IN cord-007788-09t52zix 431 42 bleeding bleed VBG cord-007788-09t52zix 431 43 . . . cord-007788-09t52zix 432 1 It -PRON- PRP cord-007788-09t52zix 432 2 is be VBZ cord-007788-09t52zix 432 3 important important JJ cord-007788-09t52zix 432 4 to to TO cord-007788-09t52zix 432 5 perform perform VB cord-007788-09t52zix 432 6 a a DT cord-007788-09t52zix 432 7 risk risk NN cord-007788-09t52zix 432 8 assessment assessment NN cord-007788-09t52zix 432 9 considering consider VBG cord-007788-09t52zix 432 10 the the DT cord-007788-09t52zix 432 11 risk risk NN cord-007788-09t52zix 432 12 factors factor NNS cord-007788-09t52zix 432 13 mentioned mention VBN cord-007788-09t52zix 432 14 above above RB cord-007788-09t52zix 432 15 and and CC cord-007788-09t52zix 432 16 to to TO cord-007788-09t52zix 432 17 take take VB cord-007788-09t52zix 432 18 baseline baseline JJ cord-007788-09t52zix 432 19 measurements measurement NNS cord-007788-09t52zix 432 20 including include VBG cord-007788-09t52zix 432 21 defining define VBG cord-007788-09t52zix 432 22 a a DT cord-007788-09t52zix 432 23 threshold threshold NN cord-007788-09t52zix 432 24 of of IN cord-007788-09t52zix 432 25 > > XX cord-007788-09t52zix 432 26 5 5 CD cord-007788-09t52zix 432 27 % % NN cord-007788-09t52zix 432 28 for for IN cord-007788-09t52zix 432 29 weight weight NN cord-007788-09t52zix 432 30 gain gain NN cord-007788-09t52zix 432 31 or or CC cord-007788-09t52zix 432 32 what what WDT cord-007788-09t52zix 432 33 level level NN cord-007788-09t52zix 432 34 and and CC cord-007788-09t52zix 432 35 pattern pattern NN cord-007788-09t52zix 432 36 of of IN cord-007788-09t52zix 432 37 weight weight NN cord-007788-09t52zix 432 38 gain gain NN cord-007788-09t52zix 432 39 that that WDT cord-007788-09t52zix 432 40 represents represent VBZ cord-007788-09t52zix 432 41 a a DT cord-007788-09t52zix 432 42 clinical clinical JJ cord-007788-09t52zix 432 43 concern concern NN cord-007788-09t52zix 432 44 . . . cord-007788-09t52zix 433 1 Most Most JJS cord-007788-09t52zix 433 2 baseline baseline JJ cord-007788-09t52zix 433 3 measurements measurement NNS cord-007788-09t52zix 433 4 will will MD cord-007788-09t52zix 433 5 be be VB cord-007788-09t52zix 433 6 standard standard JJ cord-007788-09t52zix 433 7 for for IN cord-007788-09t52zix 433 8 HSCT HSCT NNP cord-007788-09t52zix 433 9 patients patient NNS cord-007788-09t52zix 433 10 , , , cord-007788-09t52zix 433 11 but but CC cord-007788-09t52zix 433 12 in in IN cord-007788-09t52zix 433 13 patients patient NNS cord-007788-09t52zix 433 14 at at IN cord-007788-09t52zix 433 15 high high JJ cord-007788-09t52zix 433 16 risk risk NN cord-007788-09t52zix 433 17 for for IN cord-007788-09t52zix 433 18 SOS SOS NNP cord-007788-09t52zix 433 19 / / SYM cord-007788-09t52zix 433 20 VOD VOD NNP cord-007788-09t52zix 433 21 , , , cord-007788-09t52zix 433 22 assessments assessment NNS cord-007788-09t52zix 433 23 of of IN cord-007788-09t52zix 433 24 abdominal abdominal JJ cord-007788-09t52zix 433 25 girth girth NN cord-007788-09t52zix 433 26 , , , cord-007788-09t52zix 433 27 right right JJ cord-007788-09t52zix 433 28 upper upper JJ cord-007788-09t52zix 433 29 quadrant quadrant NN cord-007788-09t52zix 433 30 ( ( -LRB- cord-007788-09t52zix 433 31 RUQ RUQ NNP cord-007788-09t52zix 433 32 ) ) -RRB- cord-007788-09t52zix 433 33 pain pain NN cord-007788-09t52zix 433 34 and and CC cord-007788-09t52zix 433 35 inspection inspection NN cord-007788-09t52zix 433 36 of of IN cord-007788-09t52zix 433 37 sclera sclera NN cord-007788-09t52zix 433 38 should should MD cord-007788-09t52zix 433 39 be be VB cord-007788-09t52zix 433 40 added add VBN cord-007788-09t52zix 433 41 . . . cord-007788-09t52zix 434 1 Standard standard JJ cord-007788-09t52zix 434 2 daily daily JJ cord-007788-09t52zix 434 3 monitoring monitoring NN cord-007788-09t52zix 434 4 should should MD cord-007788-09t52zix 434 5 include include VB cord-007788-09t52zix 434 6 temperature temperature NN cord-007788-09t52zix 434 7 , , , cord-007788-09t52zix 434 8 pulse pulse NN cord-007788-09t52zix 434 9 , , , cord-007788-09t52zix 434 10 blood blood NN cord-007788-09t52zix 434 11 pressure pressure NN cord-007788-09t52zix 434 12 , , , cord-007788-09t52zix 434 13 respiration respiration NN cord-007788-09t52zix 434 14 rate rate NN cord-007788-09t52zix 434 15 and and CC cord-007788-09t52zix 434 16 saturation saturation NN cord-007788-09t52zix 434 17 . . . cord-007788-09t52zix 435 1 One one CD cord-007788-09t52zix 435 2 of of IN cord-007788-09t52zix 435 3 the the DT cord-007788-09t52zix 435 4 most most RBS cord-007788-09t52zix 435 5 important important JJ cord-007788-09t52zix 435 6 daily daily JJ cord-007788-09t52zix 435 7 monitoring monitoring NN cord-007788-09t52zix 435 8 aspects aspect NNS cord-007788-09t52zix 435 9 is be VBZ cord-007788-09t52zix 435 10 an an DT cord-007788-09t52zix 435 11 accurate accurate JJ cord-007788-09t52zix 435 12 fluid fluid JJ cord-007788-09t52zix 435 13 balance balance NN cord-007788-09t52zix 435 14 including include VBG cord-007788-09t52zix 435 15 intake intake NN cord-007788-09t52zix 435 16 , , , cord-007788-09t52zix 435 17 output output NN cord-007788-09t52zix 435 18 and and CC cord-007788-09t52zix 435 19 weight weight NN cord-007788-09t52zix 435 20 since since IN cord-007788-09t52zix 435 21 fluid fluid JJ cord-007788-09t52zix 435 22 imbalance imbalance NN cord-007788-09t52zix 435 23 is be VBZ cord-007788-09t52zix 435 24 one one CD cord-007788-09t52zix 435 25 of of IN cord-007788-09t52zix 435 26 the the DT cord-007788-09t52zix 435 27 earliest early JJS cord-007788-09t52zix 435 28 signs sign NNS cord-007788-09t52zix 435 29 of of IN cord-007788-09t52zix 435 30 SOS SOS NNP cord-007788-09t52zix 435 31 / / SYM cord-007788-09t52zix 435 32 VOD VOD NNP cord-007788-09t52zix 435 33 . . . cord-007788-09t52zix 436 1 A a DT cord-007788-09t52zix 436 2 fluid fluid JJ cord-007788-09t52zix 436 3 retention retention NN cord-007788-09t52zix 436 4 which which WDT cord-007788-09t52zix 436 5 does do VBZ cord-007788-09t52zix 436 6 not not RB cord-007788-09t52zix 436 7 respond respond VB cord-007788-09t52zix 436 8 to to IN cord-007788-09t52zix 436 9 diuretics diuretic NNS cord-007788-09t52zix 436 10 represents represent VBZ cord-007788-09t52zix 436 11 an an DT cord-007788-09t52zix 436 12 early early JJ cord-007788-09t52zix 436 13 sign sign NN cord-007788-09t52zix 436 14 of of IN cord-007788-09t52zix 436 15 endothelial endothelial JJ cord-007788-09t52zix 436 16 damage damage NN cord-007788-09t52zix 436 17 . . . cord-007788-09t52zix 437 1 When when WRB cord-007788-09t52zix 437 2 performing perform VBG cord-007788-09t52zix 437 3 abdominal abdominal JJ cord-007788-09t52zix 437 4 girth girth NN cord-007788-09t52zix 437 5 measurement measurement NN cord-007788-09t52zix 437 6 , , , cord-007788-09t52zix 437 7 it -PRON- PRP cord-007788-09t52zix 437 8 is be VBZ cord-007788-09t52zix 437 9 advised advise VBN cord-007788-09t52zix 437 10 to to TO cord-007788-09t52zix 437 11 use use VB cord-007788-09t52zix 437 12 a a DT cord-007788-09t52zix 437 13 marked marked JJ cord-007788-09t52zix 437 14 line line NN cord-007788-09t52zix 437 15 for for IN cord-007788-09t52zix 437 16 placement placement NN cord-007788-09t52zix 437 17 of of IN cord-007788-09t52zix 437 18 the the DT cord-007788-09t52zix 437 19 measuring measuring NN cord-007788-09t52zix 437 20 tape tape NN cord-007788-09t52zix 437 21 and and CC cord-007788-09t52zix 437 22 to to TO cord-007788-09t52zix 437 23 choose choose VB cord-007788-09t52zix 437 24 one one CD cord-007788-09t52zix 437 25 position position NN cord-007788-09t52zix 437 26 ( ( -LRB- cord-007788-09t52zix 437 27 i.e. i.e. FW cord-007788-09t52zix 437 28 sitting sit VBG cord-007788-09t52zix 437 29 / / SYM cord-007788-09t52zix 437 30 standing standing NN cord-007788-09t52zix 437 31 / / SYM cord-007788-09t52zix 437 32 lying lying NN cord-007788-09t52zix 437 33 ) ) -RRB- cord-007788-09t52zix 437 34 for for IN cord-007788-09t52zix 437 35 the the DT cord-007788-09t52zix 437 36 patient patient NN cord-007788-09t52zix 437 37 , , , cord-007788-09t52zix 437 38 to to TO cord-007788-09t52zix 437 39 be be VB cord-007788-09t52zix 437 40 used use VBN cord-007788-09t52zix 437 41 consequently consequently RB cord-007788-09t52zix 437 42 . . . cord-007788-09t52zix 438 1 Abdominal abdominal JJ cord-007788-09t52zix 438 2 discomfort discomfort NN cord-007788-09t52zix 438 3 , , , cord-007788-09t52zix 438 4 tenderness tenderness NN cord-007788-09t52zix 438 5 , , , cord-007788-09t52zix 438 6 pain pain NN cord-007788-09t52zix 438 7 ( ( -LRB- cord-007788-09t52zix 438 8 in in IN cord-007788-09t52zix 438 9 particular particular JJ cord-007788-09t52zix 438 10 RUQ RUQ NNP cord-007788-09t52zix 438 11 pain pain NN cord-007788-09t52zix 438 12 ) ) -RRB- cord-007788-09t52zix 438 13 and and CC cord-007788-09t52zix 438 14 inspection inspection NN cord-007788-09t52zix 438 15 for for IN cord-007788-09t52zix 438 16 collateral collateral JJ cord-007788-09t52zix 438 17 circulation circulation NN cord-007788-09t52zix 439 1 and/or and/or CC cord-007788-09t52zix 439 2 spiders spider NNS cord-007788-09t52zix 439 3 should should MD cord-007788-09t52zix 439 4 always always RB cord-007788-09t52zix 439 5 be be VB cord-007788-09t52zix 439 6 included include VBN cord-007788-09t52zix 439 7 in in IN cord-007788-09t52zix 439 8 abdominal abdominal JJ cord-007788-09t52zix 439 9 assessment assessment NN cord-007788-09t52zix 439 10 . . . cord-007788-09t52zix 440 1 For for IN cord-007788-09t52zix 440 2 nurses nurse NNS cord-007788-09t52zix 440 3 trained train VBN cord-007788-09t52zix 440 4 in in IN cord-007788-09t52zix 440 5 palpation palpation NN cord-007788-09t52zix 440 6 and and CC cord-007788-09t52zix 440 7 percussion percussion NN cord-007788-09t52zix 440 8 for for IN cord-007788-09t52zix 440 9 ascites ascites NN cord-007788-09t52zix 440 10 , , , cord-007788-09t52zix 440 11 bulkiness bulkiness NN cord-007788-09t52zix 440 12 , , , cord-007788-09t52zix 440 13 liver liver NN cord-007788-09t52zix 440 14 margins margin NNS cord-007788-09t52zix 440 15 and and CC cord-007788-09t52zix 440 16 size size NN cord-007788-09t52zix 441 1 these these DT cord-007788-09t52zix 441 2 assessments assessment NNS cord-007788-09t52zix 441 3 should should MD cord-007788-09t52zix 441 4 also also RB cord-007788-09t52zix 441 5 be be VB cord-007788-09t52zix 441 6 performed perform VBN cord-007788-09t52zix 441 7 . . . cord-007788-09t52zix 442 1 Sclera sclera NN cord-007788-09t52zix 442 2 and and CC cord-007788-09t52zix 442 3 skin skin NN cord-007788-09t52zix 442 4 should should MD cord-007788-09t52zix 442 5 be be VB cord-007788-09t52zix 442 6 assessed assess VBN cord-007788-09t52zix 442 7 for for IN cord-007788-09t52zix 442 8 bleeding bleed VBG cord-007788-09t52zix 442 9 / / SYM cord-007788-09t52zix 442 10 bruising bruising NN cord-007788-09t52zix 442 11 and and CC cord-007788-09t52zix 442 12 discoloration discoloration NN cord-007788-09t52zix 442 13 ( ( -LRB- cord-007788-09t52zix 442 14 jaundice jaundice NN cord-007788-09t52zix 442 15 ) ) -RRB- cord-007788-09t52zix 442 16 . . . cord-007788-09t52zix 443 1 Knowledge knowledge NN cord-007788-09t52zix 443 2 of of IN cord-007788-09t52zix 443 3 the the DT cord-007788-09t52zix 443 4 relevant relevant JJ cord-007788-09t52zix 443 5 reference reference NN cord-007788-09t52zix 443 6 ranges range NNS cord-007788-09t52zix 443 7 of of IN cord-007788-09t52zix 443 8 daily daily JJ cord-007788-09t52zix 443 9 laboratory laboratory NN cord-007788-09t52zix 443 10 values value NNS cord-007788-09t52zix 443 11 , , , cord-007788-09t52zix 443 12 particularly particularly RB cord-007788-09t52zix 443 13 liver liver NN cord-007788-09t52zix 443 14 enzymes enzyme NNS cord-007788-09t52zix 443 15 , , , cord-007788-09t52zix 443 16 serum serum NN cord-007788-09t52zix 443 17 bilirubin bilirubin NN cord-007788-09t52zix 443 18 , , , cord-007788-09t52zix 443 19 blood blood NN cord-007788-09t52zix 443 20 count count NN cord-007788-09t52zix 443 21 , , , cord-007788-09t52zix 443 22 electrolytes electrolyte NNS cord-007788-09t52zix 443 23 , , , cord-007788-09t52zix 443 24 urea urea NN cord-007788-09t52zix 443 25 and and CC cord-007788-09t52zix 443 26 serum serum NN cord-007788-09t52zix 443 27 creatinine creatinine NN cord-007788-09t52zix 443 28 will will MD cord-007788-09t52zix 443 29 enable enable VB cord-007788-09t52zix 443 30 early early JJ cord-007788-09t52zix 443 31 detection detection NN cord-007788-09t52zix 443 32 of of IN cord-007788-09t52zix 443 33 significant significant JJ cord-007788-09t52zix 443 34 change change NN cord-007788-09t52zix 443 35 or or CC cord-007788-09t52zix 443 36 trend trend NN cord-007788-09t52zix 443 37 in in IN cord-007788-09t52zix 443 38 values value NNS cord-007788-09t52zix 443 39 since since IN cord-007788-09t52zix 443 40 nurses nurse NNS cord-007788-09t52zix 443 41 are be VBP cord-007788-09t52zix 443 42 likely likely JJ cord-007788-09t52zix 443 43 to to TO cord-007788-09t52zix 443 44 take take VB cord-007788-09t52zix 443 45 blood blood NN cord-007788-09t52zix 443 46 samples sample NNS cord-007788-09t52zix 443 47 and and CC cord-007788-09t52zix 443 48 see see VB cord-007788-09t52zix 443 49 the the DT cord-007788-09t52zix 443 50 results result NNS cord-007788-09t52zix 443 51 first first RB cord-007788-09t52zix 443 52 and and CC cord-007788-09t52zix 443 53 can can MD cord-007788-09t52zix 443 54 alert alert VB cord-007788-09t52zix 443 55 medical medical JJ cord-007788-09t52zix 443 56 colleagues colleague NNS cord-007788-09t52zix 443 57 . . . cord-007788-09t52zix 444 1 All all DT cord-007788-09t52zix 444 2 findings finding NNS cord-007788-09t52zix 444 3 should should MD cord-007788-09t52zix 444 4 be be VB cord-007788-09t52zix 444 5 precisely precisely RB cord-007788-09t52zix 444 6 documented document VBN cord-007788-09t52zix 444 7 and and CC cord-007788-09t52zix 444 8 any any DT cord-007788-09t52zix 444 9 changes change NNS cord-007788-09t52zix 444 10 promptly promptly RB cord-007788-09t52zix 444 11 reported report VBD cord-007788-09t52zix 444 12 . . . cord-007788-09t52zix 445 1 This this DT cord-007788-09t52zix 445 2 is be VBZ cord-007788-09t52zix 445 3 especially especially RB cord-007788-09t52zix 445 4 important important JJ cord-007788-09t52zix 445 5 in in IN cord-007788-09t52zix 445 6 patients patient NNS cord-007788-09t52zix 445 7 identified identify VBN cord-007788-09t52zix 445 8 as as IN cord-007788-09t52zix 445 9 high high JJ cord-007788-09t52zix 445 10 risk risk NN cord-007788-09t52zix 445 11 as as IN cord-007788-09t52zix 445 12 early early JJ cord-007788-09t52zix 445 13 detection detection NN cord-007788-09t52zix 445 14 of of IN cord-007788-09t52zix 445 15 SOS SOS NNP cord-007788-09t52zix 445 16 / / SYM cord-007788-09t52zix 445 17 VOD VOD NNP cord-007788-09t52zix 445 18 may may MD cord-007788-09t52zix 445 19 affect affect VB cord-007788-09t52zix 445 20 the the DT cord-007788-09t52zix 445 21 overall overall JJ cord-007788-09t52zix 445 22 outcome outcome NN cord-007788-09t52zix 445 23 . . . cord-007788-09t52zix 446 1 If if IN cord-007788-09t52zix 446 2 SOS SOS NNP cord-007788-09t52zix 446 3 / / SYM cord-007788-09t52zix 446 4 VOD VOD NNP cord-007788-09t52zix 446 5 is be VBZ cord-007788-09t52zix 446 6 suspected suspect VBN cord-007788-09t52zix 446 7 , , , cord-007788-09t52zix 446 8 the the DT cord-007788-09t52zix 446 9 monitoring monitoring NN cord-007788-09t52zix 446 10 should should MD cord-007788-09t52zix 446 11 be be VB cord-007788-09t52zix 446 12 intensified intensify VBN cord-007788-09t52zix 446 13 and and CC cord-007788-09t52zix 446 14 adequate adequate JJ cord-007788-09t52zix 446 15 vascular vascular JJ cord-007788-09t52zix 446 16 access access NN cord-007788-09t52zix 446 17 established establish VBN cord-007788-09t52zix 446 18 . . . cord-007788-09t52zix 447 1 In in IN cord-007788-09t52zix 447 2 addition addition NN cord-007788-09t52zix 447 3 to to IN cord-007788-09t52zix 447 4 standard standard JJ cord-007788-09t52zix 447 5 lab lab NN cord-007788-09t52zix 447 6 tests test NNS cord-007788-09t52zix 447 7 , , , cord-007788-09t52zix 447 8 coagulation coagulation NN cord-007788-09t52zix 447 9 parameters parameter NNS cord-007788-09t52zix 447 10 should should MD cord-007788-09t52zix 447 11 be be VB cord-007788-09t52zix 447 12 performed perform VBN cord-007788-09t52zix 447 13 daily daily RB cord-007788-09t52zix 447 14 . . . cord-007788-09t52zix 448 1 If if IN cord-007788-09t52zix 448 2 possible possible JJ cord-007788-09t52zix 448 3 , , , cord-007788-09t52zix 448 4 hepatotoxic hepatotoxic JJ cord-007788-09t52zix 448 5 drugs drug NNS cord-007788-09t52zix 448 6 should should MD cord-007788-09t52zix 448 7 be be VB cord-007788-09t52zix 448 8 avoided avoid VBN cord-007788-09t52zix 448 9 and and CC cord-007788-09t52zix 448 10 diuretics diuretic NNS cord-007788-09t52zix 448 11 and and CC cord-007788-09t52zix 448 12 pain pain NN cord-007788-09t52zix 448 13 medication medication NN cord-007788-09t52zix 448 14 administered administer VBN cord-007788-09t52zix 448 15 as as IN cord-007788-09t52zix 448 16 needed need VBN cord-007788-09t52zix 448 17 . . . cord-007788-09t52zix 449 1 Electrolyte electrolyte NN cord-007788-09t52zix 449 2 replacement replacement NN cord-007788-09t52zix 449 3 may may MD cord-007788-09t52zix 449 4 be be VB cord-007788-09t52zix 449 5 necessary necessary JJ cord-007788-09t52zix 449 6 , , , cord-007788-09t52zix 449 7 and and CC cord-007788-09t52zix 449 8 in in IN cord-007788-09t52zix 449 9 case case NN cord-007788-09t52zix 449 10 of of IN cord-007788-09t52zix 449 11 thrombocytopenia thrombocytopenia NN cord-007788-09t52zix 449 12 or or CC cord-007788-09t52zix 449 13 bleeding bleed VBG cord-007788-09t52zix 449 14 , , , cord-007788-09t52zix 449 15 blood blood NN cord-007788-09t52zix 449 16 products product NNS cord-007788-09t52zix 449 17 will will MD cord-007788-09t52zix 449 18 be be VB cord-007788-09t52zix 449 19 administered administer VBN cord-007788-09t52zix 449 20 . . . cord-007788-09t52zix 450 1 If if IN cord-007788-09t52zix 450 2 fluid fluid JJ cord-007788-09t52zix 450 3 restriction restriction NN cord-007788-09t52zix 450 4 is be VBZ cord-007788-09t52zix 450 5 enforced enforce VBN cord-007788-09t52zix 450 6 , , , cord-007788-09t52zix 450 7 it -PRON- PRP cord-007788-09t52zix 450 8 is be VBZ cord-007788-09t52zix 450 9 important important JJ cord-007788-09t52zix 450 10 to to TO cord-007788-09t52zix 450 11 know know VB cord-007788-09t52zix 450 12 the the DT cord-007788-09t52zix 450 13 smallest small JJS cord-007788-09t52zix 450 14 volumes volume NNS cord-007788-09t52zix 450 15 that that WDT cord-007788-09t52zix 450 16 can can MD cord-007788-09t52zix 450 17 be be VB cord-007788-09t52zix 450 18 safely safely RB cord-007788-09t52zix 450 19 delivered deliver VBN cord-007788-09t52zix 450 20 . . . cord-007788-09t52zix 451 1 The the DT cord-007788-09t52zix 451 2 patient patient NN cord-007788-09t52zix 451 3 may may MD cord-007788-09t52zix 451 4 also also RB cord-007788-09t52zix 451 5 need need VB cord-007788-09t52zix 451 6 assistance assistance NN cord-007788-09t52zix 451 7 to to TO cord-007788-09t52zix 451 8 be be VB cord-007788-09t52zix 451 9 comfortably comfortably RB cord-007788-09t52zix 451 10 positioned position VBN cord-007788-09t52zix 451 11 . . . cord-007788-09t52zix 452 1 When when WRB cord-007788-09t52zix 452 2 SOS SOS NNP cord-007788-09t52zix 452 3 / / SYM cord-007788-09t52zix 452 4 VOD VOD NNP cord-007788-09t52zix 452 5 has have VBZ cord-007788-09t52zix 452 6 been be VBN cord-007788-09t52zix 452 7 diagnosed diagnose VBN cord-007788-09t52zix 452 8 , , , cord-007788-09t52zix 452 9 the the DT cord-007788-09t52zix 452 10 supportive supportive JJ cord-007788-09t52zix 452 11 care care NN cord-007788-09t52zix 452 12 and and CC cord-007788-09t52zix 452 13 monitoring monitoring NN cord-007788-09t52zix 452 14 will will MD cord-007788-09t52zix 452 15 be be VB cord-007788-09t52zix 452 16 further further RB cord-007788-09t52zix 452 17 intensified intensify VBN cord-007788-09t52zix 452 18 including include VBG cord-007788-09t52zix 452 19 assessing assess VBG cord-007788-09t52zix 452 20 for for IN cord-007788-09t52zix 452 21 failure failure NN cord-007788-09t52zix 452 22 in in IN cord-007788-09t52zix 452 23 respiratory respiratory JJ cord-007788-09t52zix 452 24 , , , cord-007788-09t52zix 452 25 cardiac cardiac JJ cord-007788-09t52zix 452 26 and and CC cord-007788-09t52zix 452 27 renal renal JJ cord-007788-09t52zix 452 28 function function NN cord-007788-09t52zix 452 29 . . . cord-007788-09t52zix 453 1 Defibrotide Defibrotide NNP cord-007788-09t52zix 453 2 treatment treatment NN cord-007788-09t52zix 453 3 will will MD cord-007788-09t52zix 453 4 most most RBS cord-007788-09t52zix 453 5 likely likely RB cord-007788-09t52zix 453 6 be be VB cord-007788-09t52zix 453 7 started start VBN cord-007788-09t52zix 453 8 , , , cord-007788-09t52zix 453 9 and and CC cord-007788-09t52zix 453 10 patients patient NNS cord-007788-09t52zix 453 11 in in IN cord-007788-09t52zix 453 12 need need NN cord-007788-09t52zix 453 13 for for IN cord-007788-09t52zix 453 14 ventilatory ventilatory JJ cord-007788-09t52zix 453 15 support support NN cord-007788-09t52zix 453 16 should should MD cord-007788-09t52zix 453 17 be be VB cord-007788-09t52zix 453 18 prepared prepare VBN cord-007788-09t52zix 453 19 for for IN cord-007788-09t52zix 453 20 transfer transfer NN cord-007788-09t52zix 453 21 to to IN cord-007788-09t52zix 453 22 the the DT cord-007788-09t52zix 453 23 intensive intensive JJ cord-007788-09t52zix 453 24 care care NN cord-007788-09t52zix 453 25 unit unit NN cord-007788-09t52zix 453 26 ( ( -LRB- cord-007788-09t52zix 453 27 ICU ICU NNP cord-007788-09t52zix 453 28 ) ) -RRB- cord-007788-09t52zix 453 29 . . . cord-007788-09t52zix 454 1 Patients patient NNS cord-007788-09t52zix 454 2 should should MD cord-007788-09t52zix 454 3 be be VB cord-007788-09t52zix 454 4 informed inform VBN cord-007788-09t52zix 454 5 and and CC cord-007788-09t52zix 454 6 educated educate VBN cord-007788-09t52zix 454 7 to to TO cord-007788-09t52zix 454 8 notify notify VB cord-007788-09t52zix 454 9 the the DT cord-007788-09t52zix 454 10 staff staff NN cord-007788-09t52zix 454 11 of of IN cord-007788-09t52zix 454 12 any any DT cord-007788-09t52zix 454 13 signs sign NNS cord-007788-09t52zix 454 14 and and CC cord-007788-09t52zix 454 15 symptoms symptom NNS cord-007788-09t52zix 454 16 that that WDT cord-007788-09t52zix 454 17 may may MD cord-007788-09t52zix 454 18 need need VB cord-007788-09t52zix 454 19 closer close JJR cord-007788-09t52zix 454 20 monitoring monitoring NN cord-007788-09t52zix 454 21 or or CC cord-007788-09t52zix 454 22 intervention intervention NN cord-007788-09t52zix 454 23 . . . cord-007788-09t52zix 455 1 In in IN cord-007788-09t52zix 455 2 case case NN cord-007788-09t52zix 455 3 SOS SOS NNP cord-007788-09t52zix 455 4 / / SYM cord-007788-09t52zix 455 5 VOD VOD NNP cord-007788-09t52zix 455 6 is be VBZ cord-007788-09t52zix 455 7 diagnosed diagnose VBN cord-007788-09t52zix 455 8 , , , cord-007788-09t52zix 455 9 both both DT cord-007788-09t52zix 455 10 patient patient NN cord-007788-09t52zix 455 11 and and CC cord-007788-09t52zix 455 12 family family NN cord-007788-09t52zix 455 13 will will MD cord-007788-09t52zix 455 14 need need VB cord-007788-09t52zix 455 15 reassurance reassurance NN cord-007788-09t52zix 455 16 and and CC cord-007788-09t52zix 455 17 support support NN cord-007788-09t52zix 455 18 . . . cord-007788-09t52zix 456 1 Other other JJ cord-007788-09t52zix 456 2 Early early JJ cord-007788-09t52zix 456 3 Complications complication NNS cord-007788-09t52zix 456 4 of of IN cord-007788-09t52zix 456 5 Endothelial endothelial JJ cord-007788-09t52zix 456 6 Origin Origin NNP cord-007788-09t52zix 457 1 A a DT cord-007788-09t52zix 457 2 number number NN cord-007788-09t52zix 457 3 of of IN cord-007788-09t52zix 457 4 early early JJ cord-007788-09t52zix 457 5 complications complication NNS cord-007788-09t52zix 457 6 to to IN cord-007788-09t52zix 457 7 haematopoietic haematopoietic JJ cord-007788-09t52zix 457 8 stem stem NN cord-007788-09t52zix 457 9 cell cell NN cord-007788-09t52zix 457 10 transplantation transplantation NN cord-007788-09t52zix 457 11 ( ( -LRB- cord-007788-09t52zix 457 12 HSCT HSCT NNP cord-007788-09t52zix 457 13 ) ) -RRB- cord-007788-09t52zix 457 14 seem seem VBP cord-007788-09t52zix 457 15 to to TO cord-007788-09t52zix 457 16 be be VB cord-007788-09t52zix 457 17 initiated initiate VBN cord-007788-09t52zix 457 18 by by IN cord-007788-09t52zix 457 19 damage damage NN cord-007788-09t52zix 457 20 to to IN cord-007788-09t52zix 457 21 the the DT cord-007788-09t52zix 457 22 vascular vascular JJ cord-007788-09t52zix 457 23 endothelium endothelium NN cord-007788-09t52zix 457 24 . . . cord-007788-09t52zix 458 1 The the DT cord-007788-09t52zix 458 2 most most RBS cord-007788-09t52zix 458 3 well well RB cord-007788-09t52zix 458 4 defined define VBN cord-007788-09t52zix 458 5 and and CC cord-007788-09t52zix 458 6 well well RB cord-007788-09t52zix 458 7 described describe VBN cord-007788-09t52zix 458 8 of of IN cord-007788-09t52zix 458 9 these these DT cord-007788-09t52zix 458 10 complications complication NNS cord-007788-09t52zix 458 11 is be VBZ cord-007788-09t52zix 458 12 sinusoidal sinusoidal JJ cord-007788-09t52zix 458 13 obstruction obstruction NN cord-007788-09t52zix 458 14 syndrome syndrome NN cord-007788-09t52zix 458 15 ( ( -LRB- cord-007788-09t52zix 458 16 SOS)/veno SOS)/veno NNP cord-007788-09t52zix 458 17 - - HYPH cord-007788-09t52zix 458 18 occlusive occlusive JJ cord-007788-09t52zix 458 19 disease disease NN cord-007788-09t52zix 458 20 ( ( -LRB- cord-007788-09t52zix 458 21 VOD VOD NNP cord-007788-09t52zix 458 22 ) ) -RRB- cord-007788-09t52zix 458 23 described describe VBN cord-007788-09t52zix 458 24 in in IN cord-007788-09t52zix 458 25 a a DT cord-007788-09t52zix 458 26 separate separate JJ cord-007788-09t52zix 458 27 section section NN cord-007788-09t52zix 458 28 of of IN cord-007788-09t52zix 458 29 this this DT cord-007788-09t52zix 458 30 chapter chapter NN cord-007788-09t52zix 458 31 . . . cord-007788-09t52zix 459 1 Other other JJ cord-007788-09t52zix 459 2 syndromes syndrome NNS cord-007788-09t52zix 459 3 in in IN cord-007788-09t52zix 459 4 this this DT cord-007788-09t52zix 459 5 group group NN cord-007788-09t52zix 459 6 have have VBP cord-007788-09t52zix 459 7 been be VBN cord-007788-09t52zix 459 8 named name VBN cord-007788-09t52zix 459 9 engraftment engraftment NNP cord-007788-09t52zix 459 10 syndrome syndrome NN cord-007788-09t52zix 459 11 ( ( -LRB- cord-007788-09t52zix 459 12 ES ES NNP cord-007788-09t52zix 459 13 ) ) -RRB- cord-007788-09t52zix 459 14 , , . cord-007788-09t52zix 460 1 diffuse diffuse VB cord-007788-09t52zix 460 2 alveolar alveolar NN cord-007788-09t52zix 460 3 haemorrhage haemorrhage NN cord-007788-09t52zix 460 4 ( ( -LRB- cord-007788-09t52zix 460 5 DAH DAH NNP cord-007788-09t52zix 460 6 ) ) -RRB- cord-007788-09t52zix 460 7 , , , cord-007788-09t52zix 460 8 idiopathic idiopathic JJ cord-007788-09t52zix 460 9 pneumonia pneumonia NN cord-007788-09t52zix 460 10 syndrome syndrome NN cord-007788-09t52zix 460 11 ( ( -LRB- cord-007788-09t52zix 460 12 IPS IPS NNP cord-007788-09t52zix 460 13 ) ) -RRB- cord-007788-09t52zix 460 14 and and CC cord-007788-09t52zix 460 15 transplant transplant NN cord-007788-09t52zix 460 16 - - HYPH cord-007788-09t52zix 460 17 associated associate VBN cord-007788-09t52zix 460 18 microangiopathy microangiopathy NN cord-007788-09t52zix 460 19 ( ( -LRB- cord-007788-09t52zix 460 20 TMA TMA NNP cord-007788-09t52zix 460 21 ) ) -RRB- cord-007788-09t52zix 460 22 . . . cord-007788-09t52zix 461 1 The the DT cord-007788-09t52zix 461 2 similarities similarity NNS cord-007788-09t52zix 461 3 in in IN cord-007788-09t52zix 461 4 their -PRON- PRP$ cord-007788-09t52zix 461 5 clinical clinical JJ cord-007788-09t52zix 461 6 manifestations manifestation NNS cord-007788-09t52zix 461 7 and and CC cord-007788-09t52zix 461 8 the the DT cord-007788-09t52zix 461 9 lack lack NN cord-007788-09t52zix 461 10 of of IN cord-007788-09t52zix 461 11 established establish VBN cord-007788-09t52zix 461 12 diagnostic diagnostic JJ cord-007788-09t52zix 461 13 criteria criterion NNS cord-007788-09t52zix 461 14 often often RB cord-007788-09t52zix 461 15 make make VBP cord-007788-09t52zix 461 16 determination determination NN cord-007788-09t52zix 461 17 of of IN cord-007788-09t52zix 461 18 incidence incidence NN cord-007788-09t52zix 461 19 and and CC cord-007788-09t52zix 461 20 differential differential JJ cord-007788-09t52zix 461 21 diagnosis diagnosis NN cord-007788-09t52zix 461 22 difficult difficult JJ cord-007788-09t52zix 461 23 ( ( -LRB- cord-007788-09t52zix 461 24 Soubani Soubani NNP cord-007788-09t52zix 461 25 and and CC cord-007788-09t52zix 461 26 Pandya Pandya NNP cord-007788-09t52zix 461 27 2010 2010 CD cord-007788-09t52zix 461 28 ; ; : cord-007788-09t52zix 461 29 Afessa Afessa NNP cord-007788-09t52zix 461 30 et et NNP cord-007788-09t52zix 461 31 al al NNP cord-007788-09t52zix 461 32 . . NNP cord-007788-09t52zix 461 33 2012 2012 CD cord-007788-09t52zix 461 34 ) ) -RRB- cord-007788-09t52zix 461 35 . . . cord-007788-09t52zix 462 1 Although although IN cord-007788-09t52zix 462 2 many many JJ cord-007788-09t52zix 462 3 times time NNS cord-007788-09t52zix 462 4 mild mild JJ cord-007788-09t52zix 462 5 and and CC cord-007788-09t52zix 462 6 with with IN cord-007788-09t52zix 462 7 spontaneous spontaneous JJ cord-007788-09t52zix 462 8 recovery recovery NN cord-007788-09t52zix 462 9 , , , cord-007788-09t52zix 462 10 these these DT cord-007788-09t52zix 462 11 complications complication NNS cord-007788-09t52zix 462 12 also also RB cord-007788-09t52zix 462 13 share share VBP cord-007788-09t52zix 462 14 the the DT cord-007788-09t52zix 462 15 risk risk NN cord-007788-09t52zix 462 16 for for IN cord-007788-09t52zix 462 17 progression progression NN cord-007788-09t52zix 462 18 to to IN cord-007788-09t52zix 462 19 multi multi JJ cord-007788-09t52zix 462 20 - - JJ cord-007788-09t52zix 462 21 organ organ JJ cord-007788-09t52zix 462 22 failure failure NN cord-007788-09t52zix 462 23 ( ( -LRB- cord-007788-09t52zix 462 24 MOF)/multi mof)/multi JJ cord-007788-09t52zix 462 25 - - HYPH cord-007788-09t52zix 462 26 organ organ NN cord-007788-09t52zix 462 27 damage damage NN cord-007788-09t52zix 462 28 ( ( -LRB- cord-007788-09t52zix 462 29 MOD mod NN cord-007788-09t52zix 462 30 ) ) -RRB- cord-007788-09t52zix 462 31 resulting result VBG cord-007788-09t52zix 462 32 in in IN cord-007788-09t52zix 462 33 a a DT cord-007788-09t52zix 462 34 poor poor JJ cord-007788-09t52zix 462 35 outcome outcome NN cord-007788-09t52zix 462 36 . . . cord-007788-09t52zix 463 1 Ongoing ongoing JJ cord-007788-09t52zix 463 2 research research NN cord-007788-09t52zix 463 3 and and CC cord-007788-09t52zix 463 4 efforts effort NNS cord-007788-09t52zix 463 5 for for IN cord-007788-09t52zix 463 6 better well JJR cord-007788-09t52zix 463 7 characterisation characterisation NN cord-007788-09t52zix 463 8 and and CC cord-007788-09t52zix 463 9 treatment treatment NN cord-007788-09t52zix 463 10 indicate indicate VBP cord-007788-09t52zix 463 11 that that IN cord-007788-09t52zix 463 12 there there EX cord-007788-09t52zix 463 13 will will MD cord-007788-09t52zix 463 14 be be VB cord-007788-09t52zix 463 15 future future JJ cord-007788-09t52zix 463 16 changes change NNS cord-007788-09t52zix 463 17 in in IN cord-007788-09t52zix 463 18 terminology terminology NN cord-007788-09t52zix 463 19 and and CC cord-007788-09t52zix 463 20 diagnostic diagnostic JJ cord-007788-09t52zix 463 21 criteria criterion NNS cord-007788-09t52zix 463 22 , , , cord-007788-09t52zix 463 23 as as RB cord-007788-09t52zix 463 24 well well RB cord-007788-09t52zix 463 25 as as IN cord-007788-09t52zix 463 26 interventions intervention NNS cord-007788-09t52zix 463 27 , , , cord-007788-09t52zix 463 28 for for IN cord-007788-09t52zix 463 29 the the DT cord-007788-09t52zix 463 30 early early JJ cord-007788-09t52zix 463 31 HSCT HSCT NNP cord-007788-09t52zix 463 32 complications complication NNS cord-007788-09t52zix 463 33 mentioned mention VBN cord-007788-09t52zix 463 34 here here RB cord-007788-09t52zix 463 35 . . . cord-007788-09t52zix 464 1 Several several JJ cord-007788-09t52zix 464 2 factors factor NNS cord-007788-09t52zix 464 3 in in IN cord-007788-09t52zix 464 4 the the DT cord-007788-09t52zix 464 5 HSCT HSCT NNP cord-007788-09t52zix 464 6 setting setting NN cord-007788-09t52zix 464 7 activate activate VBP cord-007788-09t52zix 464 8 the the DT cord-007788-09t52zix 464 9 endothelial endothelial JJ cord-007788-09t52zix 464 10 cells cell NNS cord-007788-09t52zix 464 11 that that WDT cord-007788-09t52zix 464 12 line line VBP cord-007788-09t52zix 464 13 the the DT cord-007788-09t52zix 464 14 blood blood NN cord-007788-09t52zix 464 15 vessels vessel NNS cord-007788-09t52zix 464 16 . . . cord-007788-09t52zix 465 1 Contributing contributing JJ cord-007788-09t52zix 465 2 factors factor NNS cord-007788-09t52zix 465 3 are be VBP cord-007788-09t52zix 465 4 the the DT cord-007788-09t52zix 465 5 conditioning conditioning NN cord-007788-09t52zix 465 6 treatment treatment NN cord-007788-09t52zix 465 7 and and CC cord-007788-09t52zix 465 8 use use NN cord-007788-09t52zix 465 9 of of IN cord-007788-09t52zix 465 10 other other JJ cord-007788-09t52zix 465 11 drugs drug NNS cord-007788-09t52zix 465 12 such such JJ cord-007788-09t52zix 465 13 as as IN cord-007788-09t52zix 465 14 granulocyte granulocyte NN cord-007788-09t52zix 465 15 colony colony NN cord-007788-09t52zix 465 16 - - HYPH cord-007788-09t52zix 465 17 stimulating stimulate VBG cord-007788-09t52zix 465 18 factor factor NN cord-007788-09t52zix 465 19 ( ( -LRB- cord-007788-09t52zix 465 20 G G NNP cord-007788-09t52zix 465 21 - - HYPH cord-007788-09t52zix 465 22 CSF CSF NNP cord-007788-09t52zix 465 23 ) ) -RRB- cord-007788-09t52zix 465 24 and and CC cord-007788-09t52zix 465 25 calcineurin calcineurin NNP cord-007788-09t52zix 465 26 inhibitors inhibitor NNS cord-007788-09t52zix 465 27 ( ( -LRB- cord-007788-09t52zix 465 28 CNI CNI NNP cord-007788-09t52zix 465 29 ) ) -RRB- cord-007788-09t52zix 465 30 , , , cord-007788-09t52zix 465 31 e.g. e.g. IN cord-007788-09t52zix 465 32 cyclosporine cyclosporine NN cord-007788-09t52zix 465 33 - - HYPH cord-007788-09t52zix 465 34 A a NN cord-007788-09t52zix 465 35 , , , cord-007788-09t52zix 465 36 and and CC cord-007788-09t52zix 465 37 microbial microbial JJ cord-007788-09t52zix 465 38 products product NNS cord-007788-09t52zix 465 39 translocated translocate VBD cord-007788-09t52zix 465 40 through through IN cord-007788-09t52zix 465 41 mucosal mucosal JJ cord-007788-09t52zix 465 42 barriers barrier NNS cord-007788-09t52zix 465 43 . . . cord-007788-09t52zix 466 1 The the DT cord-007788-09t52zix 466 2 result result NN cord-007788-09t52zix 466 3 is be VBZ cord-007788-09t52zix 466 4 that that DT cord-007788-09t52zix 466 5 fluid fluid NN cord-007788-09t52zix 466 6 and and CC cord-007788-09t52zix 466 7 proteins protein NNS cord-007788-09t52zix 466 8 leak leak VBP cord-007788-09t52zix 466 9 out out IN cord-007788-09t52zix 466 10 of of IN cord-007788-09t52zix 466 11 tiny tiny JJ cord-007788-09t52zix 466 12 blood blood NN cord-007788-09t52zix 466 13 vessels vessel NNS cord-007788-09t52zix 466 14 and and CC cord-007788-09t52zix 466 15 flow flow VB cord-007788-09t52zix 466 16 into into IN cord-007788-09t52zix 466 17 surrounding surround VBG cord-007788-09t52zix 466 18 tissues tissue NNS cord-007788-09t52zix 466 19 . . . cord-007788-09t52zix 467 1 If if IN cord-007788-09t52zix 467 2 unrecognised unrecognised JJ cord-007788-09t52zix 467 3 , , , cord-007788-09t52zix 467 4 this this DT cord-007788-09t52zix 467 5 may may MD cord-007788-09t52zix 467 6 lead lead VB cord-007788-09t52zix 467 7 to to IN cord-007788-09t52zix 467 8 dangerously dangerously RB cord-007788-09t52zix 467 9 low low JJ cord-007788-09t52zix 467 10 blood blood NN cord-007788-09t52zix 467 11 pressure pressure NN cord-007788-09t52zix 467 12 and and CC cord-007788-09t52zix 467 13 subsequently subsequently RB cord-007788-09t52zix 467 14 MOF MOF NNP cord-007788-09t52zix 467 15 and and CC cord-007788-09t52zix 467 16 shock shock NN cord-007788-09t52zix 467 17 . . . cord-007788-09t52zix 468 1 The the DT cord-007788-09t52zix 468 2 symptoms symptom NNS cord-007788-09t52zix 468 3 often often RB cord-007788-09t52zix 468 4 appear appear VBP cord-007788-09t52zix 468 5 around around IN cord-007788-09t52zix 468 6 the the DT cord-007788-09t52zix 468 7 time time NN cord-007788-09t52zix 468 8 of of IN cord-007788-09t52zix 468 9 neutrophil neutrophil NN cord-007788-09t52zix 468 10 recovery recovery NN cord-007788-09t52zix 468 11 , , , cord-007788-09t52zix 468 12 i.e. i.e. FW cord-007788-09t52zix 468 13 when when WRB cord-007788-09t52zix 468 14 the the DT cord-007788-09t52zix 468 15 absolute absolute JJ cord-007788-09t52zix 468 16 neutrophil neutrophil NN cord-007788-09t52zix 468 17 count count NN cord-007788-09t52zix 468 18 ( ( -LRB- cord-007788-09t52zix 468 19 ANC ANC NNP cord-007788-09t52zix 468 20 ) ) -RRB- cord-007788-09t52zix 468 21 increases increase VBZ cord-007788-09t52zix 468 22 to to IN cord-007788-09t52zix 468 23 ≥0.5 ≥0.5 NNP cord-007788-09t52zix 468 24 × × NNP cord-007788-09t52zix 468 25 10 10 CD cord-007788-09t52zix 468 26 9 9 CD cord-007788-09t52zix 468 27 /L /L , cord-007788-09t52zix 468 28 , , , cord-007788-09t52zix 468 29 which which WDT cord-007788-09t52zix 468 30 is be VBZ cord-007788-09t52zix 468 31 why why WRB cord-007788-09t52zix 468 32 the the DT cord-007788-09t52zix 468 33 complex complex JJ cord-007788-09t52zix 468 34 process process NN cord-007788-09t52zix 468 35 of of IN cord-007788-09t52zix 468 36 engraftment engraftment NN cord-007788-09t52zix 468 37 may may MD cord-007788-09t52zix 468 38 also also RB cord-007788-09t52zix 468 39 play play VB cord-007788-09t52zix 468 40 a a DT cord-007788-09t52zix 468 41 role role NN cord-007788-09t52zix 468 42 in in IN cord-007788-09t52zix 468 43 activation activation NN cord-007788-09t52zix 468 44 of of IN cord-007788-09t52zix 468 45 endothelial endothelial JJ cord-007788-09t52zix 468 46 cell cell NN cord-007788-09t52zix 468 47 damage damage NN cord-007788-09t52zix 468 48 . . . cord-007788-09t52zix 469 1 The the DT cord-007788-09t52zix 469 2 activation activation NN cord-007788-09t52zix 469 3 of of IN cord-007788-09t52zix 469 4 the the DT cord-007788-09t52zix 469 5 endothelial endothelial JJ cord-007788-09t52zix 469 6 cells cell NNS cord-007788-09t52zix 469 7 leads lead VBZ cord-007788-09t52zix 469 8 to to IN cord-007788-09t52zix 469 9 further further JJ cord-007788-09t52zix 469 10 damage damage NN cord-007788-09t52zix 469 11 and and CC cord-007788-09t52zix 469 12 inflammation inflammation NN cord-007788-09t52zix 469 13 by by IN cord-007788-09t52zix 469 14 the the DT cord-007788-09t52zix 469 15 release release NN cord-007788-09t52zix 469 16 of of IN cord-007788-09t52zix 469 17 pro pro JJ cord-007788-09t52zix 469 18 - - JJ cord-007788-09t52zix 469 19 inflammatory inflammatory JJ cord-007788-09t52zix 469 20 cytokines cytokine NNS cord-007788-09t52zix 469 21 . . . cord-007788-09t52zix 470 1 Since since IN cord-007788-09t52zix 470 2 the the DT cord-007788-09t52zix 470 3 incidence incidence NN cord-007788-09t52zix 470 4 of of IN cord-007788-09t52zix 470 5 vascular vascular JJ cord-007788-09t52zix 470 6 endothelial endothelial JJ cord-007788-09t52zix 470 7 syndromes syndrome NNS cord-007788-09t52zix 470 8 is be VBZ cord-007788-09t52zix 470 9 higher high JJR cord-007788-09t52zix 470 10 after after IN cord-007788-09t52zix 470 11 allogeneic allogeneic NN cord-007788-09t52zix 470 12 transplantation transplantation NN cord-007788-09t52zix 470 13 , , , cord-007788-09t52zix 470 14 alloreactivity alloreactivity NN cord-007788-09t52zix 470 15 ( ( -LRB- cord-007788-09t52zix 470 16 the the DT cord-007788-09t52zix 470 17 immune immune JJ cord-007788-09t52zix 470 18 response response NN cord-007788-09t52zix 470 19 to to IN cord-007788-09t52zix 470 20 non non JJ cord-007788-09t52zix 470 21 - - JJ cord-007788-09t52zix 470 22 self self JJ cord-007788-09t52zix 470 23 cells cell NNS cord-007788-09t52zix 470 24 ) ) -RRB- cord-007788-09t52zix 470 25 is be VBZ cord-007788-09t52zix 470 26 considered consider VBN cord-007788-09t52zix 470 27 to to TO cord-007788-09t52zix 470 28 play play VB cord-007788-09t52zix 470 29 a a DT cord-007788-09t52zix 470 30 role role NN cord-007788-09t52zix 470 31 in in IN cord-007788-09t52zix 470 32 activation activation NN cord-007788-09t52zix 470 33 and and CC cord-007788-09t52zix 470 34 damage damage NN cord-007788-09t52zix 470 35 of of IN cord-007788-09t52zix 470 36 endothelial endothelial JJ cord-007788-09t52zix 470 37 cells cell NNS cord-007788-09t52zix 470 38 . . . cord-007788-09t52zix 471 1 Engraftment Engraftment NNP cord-007788-09t52zix 471 2 Syndrome Syndrome NNP cord-007788-09t52zix 471 3 ( ( -LRB- cord-007788-09t52zix 471 4 ES ES NNP cord-007788-09t52zix 471 5 ) ) -RRB- cord-007788-09t52zix 471 6 ES ES NNP cord-007788-09t52zix 471 7 usually usually RB cord-007788-09t52zix 471 8 occurs occur VBZ cord-007788-09t52zix 471 9 after after IN cord-007788-09t52zix 471 10 auto auto NN cord-007788-09t52zix 471 11 - - HYPH cord-007788-09t52zix 471 12 HSCT HSCT NNP cord-007788-09t52zix 471 13 although although IN cord-007788-09t52zix 471 14 described describe VBN cord-007788-09t52zix 471 15 in in IN cord-007788-09t52zix 471 16 allo allo NN cord-007788-09t52zix 471 17 - - HYPH cord-007788-09t52zix 471 18 HSCT HSCT NNP cord-007788-09t52zix 471 19 as as RB cord-007788-09t52zix 471 20 well well RB cord-007788-09t52zix 471 21 , , , cord-007788-09t52zix 471 22 in in IN cord-007788-09t52zix 471 23 particular particular JJ cord-007788-09t52zix 471 24 when when WRB cord-007788-09t52zix 471 25 reduced reduce VBN cord-007788-09t52zix 471 26 intensity intensity NN cord-007788-09t52zix 471 27 conditioning conditioning NN cord-007788-09t52zix 471 28 ( ( -LRB- cord-007788-09t52zix 471 29 RIC RIC NNP cord-007788-09t52zix 471 30 ) ) -RRB- cord-007788-09t52zix 471 31 and and CC cord-007788-09t52zix 471 32 cord cord NN cord-007788-09t52zix 471 33 blood blood NN cord-007788-09t52zix 471 34 ( ( -LRB- cord-007788-09t52zix 471 35 CB CB NNP cord-007788-09t52zix 471 36 ) ) -RRB- cord-007788-09t52zix 471 37 have have VBP cord-007788-09t52zix 471 38 been be VBN cord-007788-09t52zix 471 39 used use VBN cord-007788-09t52zix 471 40 . . . cord-007788-09t52zix 472 1 Due due IN cord-007788-09t52zix 472 2 to to IN cord-007788-09t52zix 472 3 lack lack NN cord-007788-09t52zix 472 4 of of IN cord-007788-09t52zix 472 5 diagnostic diagnostic JJ cord-007788-09t52zix 472 6 criteria criterion NNS cord-007788-09t52zix 472 7 , , , cord-007788-09t52zix 472 8 the the DT cord-007788-09t52zix 472 9 term term NN cord-007788-09t52zix 472 10 ES ES NNP cord-007788-09t52zix 472 11 has have VBZ cord-007788-09t52zix 472 12 been be VBN cord-007788-09t52zix 472 13 used use VBN cord-007788-09t52zix 472 14 as as IN cord-007788-09t52zix 472 15 synonymous synonymous JJ cord-007788-09t52zix 472 16 with with IN cord-007788-09t52zix 472 17 capillary capillary JJ cord-007788-09t52zix 472 18 leak leak NN cord-007788-09t52zix 472 19 syndrome syndrome NN cord-007788-09t52zix 472 20 ( ( -LRB- cord-007788-09t52zix 472 21 CLS CLS NNP cord-007788-09t52zix 472 22 ) ) -RRB- cord-007788-09t52zix 472 23 , , , cord-007788-09t52zix 472 24 auto auto NN cord-007788-09t52zix 472 25 - - HYPH cord-007788-09t52zix 472 26 aggression aggression NN cord-007788-09t52zix 472 27 syndrome syndrome NN cord-007788-09t52zix 472 28 , , , cord-007788-09t52zix 472 29 peri peri NN cord-007788-09t52zix 472 30 - - HYPH cord-007788-09t52zix 472 31 engraftment engraftment JJ cord-007788-09t52zix 472 32 respiratory respiratory JJ cord-007788-09t52zix 472 33 distress distress NN cord-007788-09t52zix 472 34 syndrome syndrome NN cord-007788-09t52zix 472 35 ( ( -LRB- cord-007788-09t52zix 472 36 PERDS PERDS NNP cord-007788-09t52zix 472 37 ) ) -RRB- cord-007788-09t52zix 472 38 , , , cord-007788-09t52zix 472 39 aseptic aseptic JJ cord-007788-09t52zix 472 40 shock shock NN cord-007788-09t52zix 472 41 syndrome syndrome NN cord-007788-09t52zix 472 42 and and CC cord-007788-09t52zix 472 43 autologous autologous JJ cord-007788-09t52zix 472 44 graft graft NN cord-007788-09t52zix 472 45 versus versus IN cord-007788-09t52zix 472 46 host host NN cord-007788-09t52zix 472 47 disease disease NN cord-007788-09t52zix 472 48 ( ( -LRB- cord-007788-09t52zix 472 49 AGVHD AGVHD NNP cord-007788-09t52zix 472 50 ) ) -RRB- cord-007788-09t52zix 472 51 . . . cord-007788-09t52zix 473 1 Although although IN cord-007788-09t52zix 473 2 there there EX cord-007788-09t52zix 473 3 are be VBP cord-007788-09t52zix 473 4 differences difference NNS cord-007788-09t52zix 473 5 , , , cord-007788-09t52zix 473 6 their -PRON- PRP$ cord-007788-09t52zix 473 7 common common JJ cord-007788-09t52zix 473 8 denominator denominator NN cord-007788-09t52zix 473 9 is be VBZ cord-007788-09t52zix 473 10 that that IN cord-007788-09t52zix 473 11 they -PRON- PRP cord-007788-09t52zix 473 12 share share VBP cord-007788-09t52zix 473 13 some some DT cord-007788-09t52zix 473 14 or or CC cord-007788-09t52zix 473 15 all all DT cord-007788-09t52zix 473 16 symptoms symptom NNS cord-007788-09t52zix 473 17 that that WDT cord-007788-09t52zix 473 18 have have VBP cord-007788-09t52zix 473 19 been be VBN cord-007788-09t52zix 473 20 attributed attribute VBN cord-007788-09t52zix 473 21 to to IN cord-007788-09t52zix 473 22 ES ES NNP cord-007788-09t52zix 473 23 . . . cord-007788-09t52zix 474 1 Engraftment Engraftment NNP cord-007788-09t52zix 474 2 is be VBZ cord-007788-09t52zix 474 3 defined define VBN cord-007788-09t52zix 474 4 as as IN cord-007788-09t52zix 474 5 when when WRB cord-007788-09t52zix 474 6 the the DT cord-007788-09t52zix 474 7 number number NN cord-007788-09t52zix 474 8 of of IN cord-007788-09t52zix 474 9 neutrophils neutrophil NNS cord-007788-09t52zix 474 10 in in IN cord-007788-09t52zix 474 11 the the DT cord-007788-09t52zix 474 12 patient patient NN cord-007788-09t52zix 474 13 's 's POS cord-007788-09t52zix 474 14 blood blood NN cord-007788-09t52zix 474 15 rises rise VBZ cord-007788-09t52zix 474 16 to to IN cord-007788-09t52zix 474 17 an an DT cord-007788-09t52zix 474 18 absolute absolute JJ cord-007788-09t52zix 474 19 neutrophil neutrophil NN cord-007788-09t52zix 474 20 count count NN cord-007788-09t52zix 474 21 ( ( -LRB- cord-007788-09t52zix 474 22 ANC ANC NNP cord-007788-09t52zix 474 23 ) ) -RRB- cord-007788-09t52zix 474 24 of of IN cord-007788-09t52zix 474 25 ≥0.5 ≥0.5 NNP cord-007788-09t52zix 474 26 × × NNP cord-007788-09t52zix 474 27 10 10 CD cord-007788-09t52zix 475 1 9 9 LS cord-007788-09t52zix 475 2 /L. /l. CD cord-007788-09t52zix 475 3 Peri Peri NNP cord-007788-09t52zix 475 4 - - HYPH cord-007788-09t52zix 475 5 engraftment engraftment NN cord-007788-09t52zix 475 6 can can MD cord-007788-09t52zix 475 7 be be VB cord-007788-09t52zix 475 8 defined define VBN cord-007788-09t52zix 475 9 as as IN cord-007788-09t52zix 475 10 the the DT cord-007788-09t52zix 475 11 period period NN cord-007788-09t52zix 475 12 within within IN cord-007788-09t52zix 475 13 5 5 CD cord-007788-09t52zix 475 14 days day NNS cord-007788-09t52zix 475 15 of of IN cord-007788-09t52zix 475 16 neutrophil neutrophil NN cord-007788-09t52zix 475 17 engraftment engraftment NN cord-007788-09t52zix 475 18 . . . cord-007788-09t52zix 476 1 Due due IN cord-007788-09t52zix 476 2 to to IN cord-007788-09t52zix 476 3 the the DT cord-007788-09t52zix 476 4 diagnosis diagnosis NN cord-007788-09t52zix 476 5 difficulties difficulty NNS cord-007788-09t52zix 476 6 , , , cord-007788-09t52zix 476 7 there there EX cord-007788-09t52zix 476 8 is be VBZ cord-007788-09t52zix 476 9 no no DT cord-007788-09t52zix 476 10 reliable reliable JJ cord-007788-09t52zix 476 11 incidence incidence NN cord-007788-09t52zix 476 12 figure figure NN cord-007788-09t52zix 476 13 and and CC cord-007788-09t52zix 476 14 numbers number NNS cord-007788-09t52zix 476 15 between between IN cord-007788-09t52zix 476 16 10 10 CD cord-007788-09t52zix 476 17 % % NN cord-007788-09t52zix 476 18 and and CC cord-007788-09t52zix 476 19 70 70 CD cord-007788-09t52zix 476 20 % % NN cord-007788-09t52zix 476 21 have have VBP cord-007788-09t52zix 476 22 been be VBN cord-007788-09t52zix 476 23 reported report VBN cord-007788-09t52zix 476 24 . . . cord-007788-09t52zix 477 1 There there EX cord-007788-09t52zix 477 2 is be VBZ cord-007788-09t52zix 477 3 also also RB cord-007788-09t52zix 477 4 a a DT cord-007788-09t52zix 477 5 lack lack NN cord-007788-09t52zix 477 6 of of IN cord-007788-09t52zix 477 7 survival survival NN cord-007788-09t52zix 477 8 data datum NNS cord-007788-09t52zix 477 9 . . . cord-007788-09t52zix 478 1 Most Most JJS cord-007788-09t52zix 478 2 cases case NNS cord-007788-09t52zix 478 3 are be VBP cord-007788-09t52zix 478 4 mild mild JJ cord-007788-09t52zix 478 5 and and CC cord-007788-09t52zix 478 6 respond respond VB cord-007788-09t52zix 478 7 well well RB cord-007788-09t52zix 478 8 to to IN cord-007788-09t52zix 478 9 corticosteroid corticosteroid NN cord-007788-09t52zix 478 10 therapy therapy NN cord-007788-09t52zix 478 11 , , , cord-007788-09t52zix 478 12 but but CC cord-007788-09t52zix 478 13 ES ES NNP cord-007788-09t52zix 478 14 may may MD cord-007788-09t52zix 478 15 progress progress VB cord-007788-09t52zix 478 16 and and CC cord-007788-09t52zix 478 17 lead lead VB cord-007788-09t52zix 478 18 to to IN cord-007788-09t52zix 478 19 transplant transplant NN cord-007788-09t52zix 478 20 - - HYPH cord-007788-09t52zix 478 21 related relate VBN cord-007788-09t52zix 478 22 mortality mortality NN cord-007788-09t52zix 478 23 and and CC cord-007788-09t52zix 478 24 decrease decrease NN cord-007788-09t52zix 478 25 in in IN cord-007788-09t52zix 478 26 overall overall JJ cord-007788-09t52zix 478 27 survival survival NN cord-007788-09t52zix 478 28 . . . cord-007788-09t52zix 479 1 Patients patient NNS cord-007788-09t52zix 479 2 who who WP cord-007788-09t52zix 479 3 require require VBP cord-007788-09t52zix 479 4 mechanical mechanical JJ cord-007788-09t52zix 479 5 ventilation ventilation NN cord-007788-09t52zix 479 6 has have VBZ cord-007788-09t52zix 479 7 a a DT cord-007788-09t52zix 479 8 poor poor JJ cord-007788-09t52zix 479 9 prognosis prognosis NN cord-007788-09t52zix 479 10 . . . cord-007788-09t52zix 480 1 A a DT cord-007788-09t52zix 480 2 number number NN cord-007788-09t52zix 480 3 of of IN cord-007788-09t52zix 480 4 potential potential JJ cord-007788-09t52zix 480 5 risk risk NN cord-007788-09t52zix 480 6 factors factor NNS cord-007788-09t52zix 480 7 related relate VBN cord-007788-09t52zix 480 8 to to IN cord-007788-09t52zix 480 9 patient patient JJ cord-007788-09t52zix 480 10 characteristics characteristic NNS cord-007788-09t52zix 480 11 , , , cord-007788-09t52zix 480 12 disease disease NN cord-007788-09t52zix 480 13 , , , cord-007788-09t52zix 480 14 previous previous JJ cord-007788-09t52zix 480 15 treatment treatment NN cord-007788-09t52zix 480 16 , , , cord-007788-09t52zix 480 17 conditioning conditioning NN cord-007788-09t52zix 480 18 treatment treatment NN cord-007788-09t52zix 480 19 , , , cord-007788-09t52zix 480 20 stem stem NN cord-007788-09t52zix 480 21 cell cell NN cord-007788-09t52zix 480 22 source source NN cord-007788-09t52zix 480 23 and and CC cord-007788-09t52zix 480 24 supportive supportive JJ cord-007788-09t52zix 480 25 drug drug NN cord-007788-09t52zix 480 26 treatment treatment NN cord-007788-09t52zix 480 27 have have VBP cord-007788-09t52zix 480 28 been be VBN cord-007788-09t52zix 480 29 reported report VBN cord-007788-09t52zix 480 30 , , , cord-007788-09t52zix 480 31 but but CC cord-007788-09t52zix 480 32 there there EX cord-007788-09t52zix 480 33 is be VBZ cord-007788-09t52zix 480 34 a a DT cord-007788-09t52zix 480 35 lack lack NN cord-007788-09t52zix 480 36 of of IN cord-007788-09t52zix 480 37 consensus consensus NN cord-007788-09t52zix 480 38 which which WDT cord-007788-09t52zix 480 39 can can MD cord-007788-09t52zix 480 40 in in IN cord-007788-09t52zix 480 41 part part NN cord-007788-09t52zix 480 42 be be VB cord-007788-09t52zix 480 43 contributed contribute VBN cord-007788-09t52zix 480 44 to to IN cord-007788-09t52zix 480 45 the the DT cord-007788-09t52zix 480 46 lack lack NN cord-007788-09t52zix 480 47 of of IN cord-007788-09t52zix 480 48 diagnostic diagnostic JJ cord-007788-09t52zix 480 49 criteria criterion NNS cord-007788-09t52zix 480 50 . . . cord-007788-09t52zix 481 1 Changes change NNS cord-007788-09t52zix 481 2 in in IN cord-007788-09t52zix 481 3 HSCT HSCT NNP cord-007788-09t52zix 481 4 practices practice NNS cord-007788-09t52zix 481 5 with with IN cord-007788-09t52zix 481 6 new new JJ cord-007788-09t52zix 481 7 drugs drug NNS cord-007788-09t52zix 481 8 and and CC cord-007788-09t52zix 481 9 alternate alternate JJ cord-007788-09t52zix 481 10 stem stem NN cord-007788-09t52zix 481 11 cell cell NN cord-007788-09t52zix 481 12 sources source NNS cord-007788-09t52zix 481 13 may may MD cord-007788-09t52zix 481 14 impact impact VB cord-007788-09t52zix 481 15 the the DT cord-007788-09t52zix 481 16 risk risk NN cord-007788-09t52zix 481 17 factors factor NNS cord-007788-09t52zix 481 18 in in IN cord-007788-09t52zix 481 19 the the DT cord-007788-09t52zix 481 20 future future NN cord-007788-09t52zix 481 21 . . . cord-007788-09t52zix 482 1 Among among IN cord-007788-09t52zix 482 2 the the DT cord-007788-09t52zix 482 3 risk risk NN cord-007788-09t52zix 482 4 factors factor NNS cord-007788-09t52zix 482 5 described describe VBN cord-007788-09t52zix 482 6 are be VBP cord-007788-09t52zix 482 7 : : : cord-007788-09t52zix 482 8 • • . cord-007788-09t52zix 483 1 Female female JJ cord-007788-09t52zix 483 2 gender gender NN cord-007788-09t52zix 484 1 • • NNP cord-007788-09t52zix 485 1 Advanced advanced JJ cord-007788-09t52zix 485 2 age age NN cord-007788-09t52zix 486 1 • • NNP cord-007788-09t52zix 487 1 No no UH cord-007788-09t52zix 488 1 or or CC cord-007788-09t52zix 488 2 little little JJ cord-007788-09t52zix 489 1 prior prior JJ cord-007788-09t52zix 489 2 chemotherapy chemotherapy NN cord-007788-09t52zix 490 1 • • NNP cord-007788-09t52zix 491 1 Previous previous JJ cord-007788-09t52zix 491 2 use use NN cord-007788-09t52zix 491 3 of of IN cord-007788-09t52zix 491 4 bortezomib bortezomib NNP cord-007788-09t52zix 491 5 and and CC cord-007788-09t52zix 491 6 lenalidomide lenalidomide NN cord-007788-09t52zix 491 7 in in IN cord-007788-09t52zix 491 8 multiple multiple JJ cord-007788-09t52zix 491 9 myeloma myeloma NN cord-007788-09t52zix 491 10 patients patient NNS cord-007788-09t52zix 492 1 • • NNP cord-007788-09t52zix 493 1 Cord cord NN cord-007788-09t52zix 493 2 blood blood NN cord-007788-09t52zix 493 3 transplantation transplantation NN cord-007788-09t52zix 494 1 • • NNP cord-007788-09t52zix 495 1 CD34 CD34 NNP cord-007788-09t52zix 495 2 + + CC cord-007788-09t52zix 495 3 cell cell NN cord-007788-09t52zix 495 4 number number NN cord-007788-09t52zix 495 5 and and CC cord-007788-09t52zix 495 6 engraftment engraftment NN cord-007788-09t52zix 495 7 rate rate NN cord-007788-09t52zix 496 1 • • NNP cord-007788-09t52zix 496 2 G G NNP cord-007788-09t52zix 496 3 - - HYPH cord-007788-09t52zix 496 4 CSF csf NN cord-007788-09t52zix 496 5 treatment treatment NN cord-007788-09t52zix 497 1 • • NNP cord-007788-09t52zix 498 1 Amphotericin amphotericin NN cord-007788-09t52zix 498 2 treatment treatment NN cord-007788-09t52zix 499 1 • • NNP cord-007788-09t52zix 500 1 Cyclosporine Cyclosporine NNP cord-007788-09t52zix 500 2 ( ( -LRB- cord-007788-09t52zix 500 3 CyA cya NN cord-007788-09t52zix 500 4 ) ) -RRB- cord-007788-09t52zix 500 5 treatment treatment NN cord-007788-09t52zix 501 1 • • NNP cord-007788-09t52zix 501 2 Auto Auto NNP cord-007788-09t52zix 501 3 - - HYPH cord-007788-09t52zix 501 4 HSCT HSCT NNP cord-007788-09t52zix 501 5 for for IN cord-007788-09t52zix 501 6 amyloidosis amyloidosis NN cord-007788-09t52zix 501 7 , , , cord-007788-09t52zix 501 8 multiple multiple JJ cord-007788-09t52zix 501 9 myeloma myeloma NN cord-007788-09t52zix 501 10 , , , cord-007788-09t52zix 501 11 POEMS poem NNS cord-007788-09t52zix 501 12 ( ( -LRB- cord-007788-09t52zix 502 1 polyneuropathy polyneuropathy NNP cord-007788-09t52zix 502 2 organomegaly organomegaly NNP cord-007788-09t52zix 502 3 endocrinopathy endocrinopathy NNP cord-007788-09t52zix 502 4 monoclonal monoclonal NNP cord-007788-09t52zix 502 5 protein protein NN cord-007788-09t52zix 502 6 and and CC cord-007788-09t52zix 502 7 skin skin NN cord-007788-09t52zix 502 8 abnormalities abnormality NNS cord-007788-09t52zix 502 9 ) ) -RRB- cord-007788-09t52zix 502 10 syndrome syndrome NN cord-007788-09t52zix 502 11 and and CC cord-007788-09t52zix 502 12 autoimmune autoimmune JJ cord-007788-09t52zix 502 13 diseases disease NNS cord-007788-09t52zix 503 1 There there EX cord-007788-09t52zix 503 2 are be VBP cord-007788-09t52zix 503 3 two two CD cord-007788-09t52zix 503 4 tools tool NNS cord-007788-09t52zix 503 5 to to TO cord-007788-09t52zix 503 6 aid aid VB cord-007788-09t52zix 503 7 diagnosis diagnosis NN cord-007788-09t52zix 503 8 of of IN cord-007788-09t52zix 503 9 ES ES NNP cord-007788-09t52zix 503 10 ; ; : cord-007788-09t52zix 503 11 the the DT cord-007788-09t52zix 503 12 Spitzer Spitzer NNP cord-007788-09t52zix 503 13 ( ( -LRB- cord-007788-09t52zix 503 14 2001 2001 CD cord-007788-09t52zix 503 15 ) ) -RRB- cord-007788-09t52zix 503 16 and and CC cord-007788-09t52zix 503 17 the the DT cord-007788-09t52zix 503 18 Maiolino Maiolino NNP cord-007788-09t52zix 503 19 et et NNP cord-007788-09t52zix 503 20 al al NNP cord-007788-09t52zix 503 21 . . . cord-007788-09t52zix 504 1 ( ( -LRB- cord-007788-09t52zix 504 2 2003 2003 CD cord-007788-09t52zix 504 3 ) ) -RRB- cord-007788-09t52zix 504 4 diagnostic diagnostic JJ cord-007788-09t52zix 504 5 criteria criterion NNS cord-007788-09t52zix 504 6 . . . cord-007788-09t52zix 505 1 The the DT cord-007788-09t52zix 505 2 clinical clinical JJ cord-007788-09t52zix 505 3 manifestations manifestation NNS cord-007788-09t52zix 505 4 are be VBP cord-007788-09t52zix 505 5 divided divide VBN cord-007788-09t52zix 505 6 into into IN cord-007788-09t52zix 505 7 major major JJ cord-007788-09t52zix 505 8 or or CC cord-007788-09t52zix 505 9 minor minor JJ cord-007788-09t52zix 505 10 clinical clinical JJ cord-007788-09t52zix 505 11 criteria criterion NNS cord-007788-09t52zix 505 12 ( ( -LRB- cord-007788-09t52zix 505 13 Table table NN cord-007788-09t52zix 505 14 9 9 CD cord-007788-09t52zix 505 15 .7 .7 NFP cord-007788-09t52zix 505 16 ) ) -RRB- cord-007788-09t52zix 505 17 , , , cord-007788-09t52zix 505 18 but but CC cord-007788-09t52zix 505 19 Maiolino Maiolino NNP cord-007788-09t52zix 505 20 only only RB cord-007788-09t52zix 505 21 has have VBZ cord-007788-09t52zix 505 22 one one CD cord-007788-09t52zix 505 23 major major JJ cord-007788-09t52zix 505 24 criteria criterion NNS cord-007788-09t52zix 505 25 , , , cord-007788-09t52zix 505 26 non non JJ cord-007788-09t52zix 505 27 - - JJ cord-007788-09t52zix 505 28 infectious infectious JJ cord-007788-09t52zix 505 29 fever fever NN cord-007788-09t52zix 505 30 . . . cord-007788-09t52zix 506 1 The the DT cord-007788-09t52zix 506 2 timing timing NN cord-007788-09t52zix 506 3 of of IN cord-007788-09t52zix 506 4 symptoms symptom NNS cord-007788-09t52zix 506 5 relative relative JJ cord-007788-09t52zix 506 6 engraftment engraftment NN cord-007788-09t52zix 506 7 also also RB cord-007788-09t52zix 506 8 differs differ VBZ cord-007788-09t52zix 506 9 between between IN cord-007788-09t52zix 506 10 the the DT cord-007788-09t52zix 506 11 two two CD cord-007788-09t52zix 506 12 , , , cord-007788-09t52zix 506 13 where where WRB cord-007788-09t52zix 506 14 Maiolino Maiolino NNP cord-007788-09t52zix 506 15 has have VBZ cord-007788-09t52zix 506 16 a a DT cord-007788-09t52zix 506 17 stricter strict JJR cord-007788-09t52zix 506 18 timeframe timeframe NN cord-007788-09t52zix 506 19 from from IN cord-007788-09t52zix 506 20 24 24 CD cord-007788-09t52zix 506 21 h h NN cord-007788-09t52zix 506 22 before before RB cord-007788-09t52zix 506 23 to to IN cord-007788-09t52zix 506 24 any any DT cord-007788-09t52zix 506 25 time time NN cord-007788-09t52zix 506 26 after after IN cord-007788-09t52zix 506 27 neutrophil neutrophil NN cord-007788-09t52zix 506 28 recovery recovery NN cord-007788-09t52zix 506 29 compared compare VBN cord-007788-09t52zix 506 30 to to IN cord-007788-09t52zix 506 31 Spitzer Spitzer NNP cord-007788-09t52zix 506 32 's 's POS cord-007788-09t52zix 506 33 96 96 CD cord-007788-09t52zix 506 34 h h NN cord-007788-09t52zix 506 35 after after IN cord-007788-09t52zix 506 36 ( ( -LRB- cord-007788-09t52zix 506 37 Table table NN cord-007788-09t52zix 506 38 9 9 CD cord-007788-09t52zix 506 39 .8 .8 CD cord-007788-09t52zix 506 40 ) ) -RRB- cord-007788-09t52zix 506 41 . . . cord-007788-09t52zix 507 1 However however RB cord-007788-09t52zix 507 2 , , , cord-007788-09t52zix 507 3 in in IN cord-007788-09t52zix 507 4 some some DT cord-007788-09t52zix 507 5 patients patient NNS cord-007788-09t52zix 507 6 others other NNS cord-007788-09t52zix 507 7 have have VBP cord-007788-09t52zix 507 8 described describe VBN cord-007788-09t52zix 507 9 onset onset NN cord-007788-09t52zix 507 10 of of IN cord-007788-09t52zix 507 11 symptoms symptom NNS cord-007788-09t52zix 507 12 from from IN cord-007788-09t52zix 507 13 7 7 CD cord-007788-09t52zix 507 14 days day NNS cord-007788-09t52zix 507 15 before before RB cord-007788-09t52zix 507 16 ( ( -LRB- cord-007788-09t52zix 507 17 for for IN cord-007788-09t52zix 507 18 patients patient NNS cord-007788-09t52zix 507 19 with with IN cord-007788-09t52zix 507 20 POEMS poem NNS cord-007788-09t52zix 507 21 ) ) -RRB- cord-007788-09t52zix 507 22 to to IN cord-007788-09t52zix 507 23 7 7 CD cord-007788-09t52zix 507 24 days day NNS cord-007788-09t52zix 507 25 after after IN cord-007788-09t52zix 507 26 engraftment engraftment NN cord-007788-09t52zix 507 27 , , , cord-007788-09t52zix 507 28 and and CC cord-007788-09t52zix 507 29 in in IN cord-007788-09t52zix 507 30 cases case NNS cord-007788-09t52zix 507 31 with with IN cord-007788-09t52zix 507 32 more more RBR cord-007788-09t52zix 507 33 severe severe JJ cord-007788-09t52zix 507 34 symptoms symptom NNS cord-007788-09t52zix 507 35 , , , cord-007788-09t52zix 507 36 the the DT cord-007788-09t52zix 507 37 early early JJ cord-007788-09t52zix 507 38 symptoms symptom NNS cord-007788-09t52zix 507 39 may may MD cord-007788-09t52zix 507 40 have have VB cord-007788-09t52zix 507 41 been be VBN cord-007788-09t52zix 507 42 overlooked overlook VBN cord-007788-09t52zix 507 43 , , , cord-007788-09t52zix 507 44 why why WRB cord-007788-09t52zix 507 45 the the DT cord-007788-09t52zix 507 46 clinical clinical JJ cord-007788-09t52zix 507 47 criteria criterion NNS cord-007788-09t52zix 507 48 sometimes sometimes RB cord-007788-09t52zix 507 49 could could MD cord-007788-09t52zix 507 50 be be VB cord-007788-09t52zix 507 51 used use VBN cord-007788-09t52zix 507 52 regardless regardless RB cord-007788-09t52zix 507 53 of of IN cord-007788-09t52zix 507 54 appearance appearance NN cord-007788-09t52zix 507 55 of of IN cord-007788-09t52zix 507 56 symptoms symptom NNS cord-007788-09t52zix 507 57 in in IN cord-007788-09t52zix 507 58 relation relation NN cord-007788-09t52zix 507 59 to to IN cord-007788-09t52zix 507 60 time time NN cord-007788-09t52zix 507 61 for for IN cord-007788-09t52zix 507 62 engraftment engraftment NN cord-007788-09t52zix 508 1 ( ( -LRB- cord-007788-09t52zix 508 2 Chang Chang NNP cord-007788-09t52zix 508 3 et et NNP cord-007788-09t52zix 508 4 al al NNP cord-007788-09t52zix 508 5 . . NNP cord-007788-09t52zix 508 6 2014 2014 CD cord-007788-09t52zix 508 7 ) ) -RRB- cord-007788-09t52zix 508 8 . . . cord-007788-09t52zix 509 1 C C NNP cord-007788-09t52zix 509 2 - - HYPH cord-007788-09t52zix 509 3 reactive reactive JJ cord-007788-09t52zix 509 4 protein protein NN cord-007788-09t52zix 509 5 ( ( -LRB- cord-007788-09t52zix 509 6 CRP CRP NNP cord-007788-09t52zix 509 7 ) ) -RRB- cord-007788-09t52zix 509 8 is be VBZ cord-007788-09t52zix 509 9 not not RB cord-007788-09t52zix 509 10 used use VBN cord-007788-09t52zix 509 11 for for IN cord-007788-09t52zix 509 12 diagnosis diagnosis NN cord-007788-09t52zix 509 13 in in IN cord-007788-09t52zix 509 14 either either DT cord-007788-09t52zix 509 15 criteria criterion NNS cord-007788-09t52zix 509 16 , , , cord-007788-09t52zix 509 17 but but CC cord-007788-09t52zix 509 18 a a DT cord-007788-09t52zix 509 19 sudden sudden JJ cord-007788-09t52zix 509 20 and and CC cord-007788-09t52zix 509 21 significant significant JJ cord-007788-09t52zix 509 22 increase increase NN cord-007788-09t52zix 509 23 in in IN cord-007788-09t52zix 509 24 the the DT cord-007788-09t52zix 509 25 CRP CRP NNP cord-007788-09t52zix 509 26 level level NN cord-007788-09t52zix 509 27 has have VBZ cord-007788-09t52zix 509 28 been be VBN cord-007788-09t52zix 509 29 found find VBN cord-007788-09t52zix 509 30 to to TO cord-007788-09t52zix 509 31 support support VB cord-007788-09t52zix 509 32 the the DT cord-007788-09t52zix 509 33 diagnosis diagnosis NN cord-007788-09t52zix 509 34 . . . cord-007788-09t52zix 509 35 _SP cord-007788-09t52zix 510 1 Early early JJ cord-007788-09t52zix 510 2 recognition recognition NN cord-007788-09t52zix 510 3 of of IN cord-007788-09t52zix 510 4 signs sign NNS cord-007788-09t52zix 510 5 and and CC cord-007788-09t52zix 510 6 symptoms symptom NNS cord-007788-09t52zix 510 7 is be VBZ cord-007788-09t52zix 510 8 the the DT cord-007788-09t52zix 510 9 most most RBS cord-007788-09t52zix 510 10 important important JJ cord-007788-09t52zix 510 11 aspect aspect NN cord-007788-09t52zix 510 12 since since IN cord-007788-09t52zix 510 13 there there EX cord-007788-09t52zix 510 14 is be VBZ cord-007788-09t52zix 510 15 no no DT cord-007788-09t52zix 510 16 standard standard JJ cord-007788-09t52zix 510 17 prophylaxis prophylaxis NN cord-007788-09t52zix 510 18 for for IN cord-007788-09t52zix 510 19 ES ES NNP cord-007788-09t52zix 510 20 , , , cord-007788-09t52zix 510 21 although although IN cord-007788-09t52zix 510 22 there there EX cord-007788-09t52zix 510 23 is be VBZ cord-007788-09t52zix 510 24 evidence evidence NN cord-007788-09t52zix 510 25 that that IN cord-007788-09t52zix 510 26 corticosteroids corticosteroid NNS cord-007788-09t52zix 510 27 may may MD cord-007788-09t52zix 510 28 prevent prevent VB cord-007788-09t52zix 510 29 this this DT cord-007788-09t52zix 510 30 complication complication NN cord-007788-09t52zix 510 31 . . . cord-007788-09t52zix 511 1 Before before IN cord-007788-09t52zix 511 2 treatment treatment NN cord-007788-09t52zix 511 3 is be VBZ cord-007788-09t52zix 511 4 initiated initiate VBN cord-007788-09t52zix 511 5 , , , cord-007788-09t52zix 511 6 other other JJ cord-007788-09t52zix 511 7 diagnoses diagnosis NNS cord-007788-09t52zix 511 8 such such JJ cord-007788-09t52zix 511 9 as as IN cord-007788-09t52zix 511 10 infection infection NN cord-007788-09t52zix 511 11 , , , cord-007788-09t52zix 511 12 drug drug NN cord-007788-09t52zix 511 13 rash rash NN cord-007788-09t52zix 511 14 , , , cord-007788-09t52zix 511 15 diarrhoea diarrhoea NN cord-007788-09t52zix 511 16 associated associate VBN cord-007788-09t52zix 511 17 with with IN cord-007788-09t52zix 511 18 infection infection NN cord-007788-09t52zix 511 19 or or CC cord-007788-09t52zix 511 20 medication medication NN cord-007788-09t52zix 511 21 and and CC cord-007788-09t52zix 511 22 intravenous intravenous JJ cord-007788-09t52zix 511 23 ( ( -LRB- cord-007788-09t52zix 511 24 i.v.)-related i.v.)-related JJ cord-007788-09t52zix 511 25 fluid fluid JJ cord-007788-09t52zix 511 26 overload overload NN cord-007788-09t52zix 511 27 should should MD cord-007788-09t52zix 511 28 be be VB cord-007788-09t52zix 511 29 excluded exclude VBN cord-007788-09t52zix 511 30 . . . cord-007788-09t52zix 512 1 Broad broad JJ cord-007788-09t52zix 512 2 - - HYPH cord-007788-09t52zix 512 3 spectrum spectrum NN cord-007788-09t52zix 512 4 antibiotics antibiotic NNS cord-007788-09t52zix 512 5 should should MD cord-007788-09t52zix 512 6 be be VB cord-007788-09t52zix 512 7 used use VBN cord-007788-09t52zix 512 8 until until IN cord-007788-09t52zix 512 9 infection infection NN cord-007788-09t52zix 512 10 is be VBZ cord-007788-09t52zix 512 11 ruled rule VBN cord-007788-09t52zix 512 12 out out RP cord-007788-09t52zix 512 13 ( ( -LRB- cord-007788-09t52zix 512 14 Cornell Cornell NNP cord-007788-09t52zix 512 15 et et NNP cord-007788-09t52zix 512 16 al al NNP cord-007788-09t52zix 512 17 . . NNP cord-007788-09t52zix 512 18 2015 2015 CD cord-007788-09t52zix 512 19 ) ) -RRB- cord-007788-09t52zix 512 20 . . . cord-007788-09t52zix 513 1 If if IN cord-007788-09t52zix 513 2 cultures culture NNS cord-007788-09t52zix 513 3 are be VBP cord-007788-09t52zix 513 4 negative negative JJ cord-007788-09t52zix 513 5 , , , cord-007788-09t52zix 513 6 symptoms symptom NNS cord-007788-09t52zix 513 7 remain remain VBP cord-007788-09t52zix 513 8 after after IN cord-007788-09t52zix 513 9 48 48 CD cord-007788-09t52zix 513 10 - - SYM cord-007788-09t52zix 513 11 72 72 CD cord-007788-09t52zix 513 12 h h NN cord-007788-09t52zix 513 13 of of IN cord-007788-09t52zix 513 14 antibiotic antibiotic JJ cord-007788-09t52zix 513 15 treatment treatment NN cord-007788-09t52zix 513 16 and and CC cord-007788-09t52zix 513 17 other other JJ cord-007788-09t52zix 513 18 etiologies etiology NNS cord-007788-09t52zix 513 19 can can MD cord-007788-09t52zix 513 20 be be VB cord-007788-09t52zix 513 21 excluded exclude VBN cord-007788-09t52zix 513 22 , , , cord-007788-09t52zix 513 23 corticosteroid corticosteroid NN cord-007788-09t52zix 513 24 treatment treatment NN cord-007788-09t52zix 513 25 can can MD cord-007788-09t52zix 513 26 be be VB cord-007788-09t52zix 513 27 initiated initiate VBN cord-007788-09t52zix 513 28 . . . cord-007788-09t52zix 514 1 Methylprednisolone Methylprednisolone NNP cord-007788-09t52zix 514 2 in in IN cord-007788-09t52zix 514 3 doses dose NNS cord-007788-09t52zix 514 4 of of IN cord-007788-09t52zix 514 5 1 1 CD cord-007788-09t52zix 514 6 - - SYM cord-007788-09t52zix 514 7 3 3 CD cord-007788-09t52zix 514 8 mg mg NNP cord-007788-09t52zix 514 9 / / SYM cord-007788-09t52zix 514 10 kg/ kg/ NNP cord-007788-09t52zix 514 11 day day NNP cord-007788-09t52zix 514 12 i.v i.v NNP cord-007788-09t52zix 514 13 . . NNP cord-007788-09t52zix 514 14 are be VBP cord-007788-09t52zix 514 15 recommended recommend VBN cord-007788-09t52zix 514 16 until until IN cord-007788-09t52zix 514 17 symptoms symptom NNS cord-007788-09t52zix 514 18 begin begin VBP cord-007788-09t52zix 514 19 to to TO cord-007788-09t52zix 514 20 subside subside VB cord-007788-09t52zix 514 21 . . . cord-007788-09t52zix 515 1 Response response NN cord-007788-09t52zix 515 2 to to IN cord-007788-09t52zix 515 3 treatment treatment NN cord-007788-09t52zix 515 4 is be VBZ cord-007788-09t52zix 515 5 usually usually RB cord-007788-09t52zix 515 6 seen see VBN cord-007788-09t52zix 515 7 within within IN cord-007788-09t52zix 515 8 2 2 CD cord-007788-09t52zix 515 9 - - SYM cord-007788-09t52zix 515 10 3 3 CD cord-007788-09t52zix 515 11 days day NNS cord-007788-09t52zix 515 12 . . . cord-007788-09t52zix 516 1 Corticosteroids corticosteroid NNS cord-007788-09t52zix 516 2 could could MD cord-007788-09t52zix 516 3 then then RB cord-007788-09t52zix 516 4 be be VB cord-007788-09t52zix 516 5 switched switch VBN cord-007788-09t52zix 516 6 to to IN cord-007788-09t52zix 516 7 oral oral JJ cord-007788-09t52zix 516 8 administration administration NN cord-007788-09t52zix 516 9 and and CC cord-007788-09t52zix 516 10 should should MD cord-007788-09t52zix 516 11 be be VB cord-007788-09t52zix 516 12 slowly slowly RB cord-007788-09t52zix 516 13 tapered taper VBN cord-007788-09t52zix 516 14 . . . cord-007788-09t52zix 517 1 Early early JJ cord-007788-09t52zix 517 2 intervention intervention NN cord-007788-09t52zix 517 3 with with IN cord-007788-09t52zix 517 4 steroids steroid NNS cord-007788-09t52zix 517 5 prevents prevent VBZ cord-007788-09t52zix 517 6 progression progression NN cord-007788-09t52zix 517 7 to to IN cord-007788-09t52zix 517 8 more more RBR cord-007788-09t52zix 517 9 severe severe JJ cord-007788-09t52zix 517 10 manifestations manifestation NNS cord-007788-09t52zix 517 11 , , , cord-007788-09t52zix 517 12 and and CC cord-007788-09t52zix 517 13 in in IN cord-007788-09t52zix 517 14 the the DT cord-007788-09t52zix 517 15 vast vast JJ cord-007788-09t52zix 517 16 majority majority NN cord-007788-09t52zix 517 17 ( ( -LRB- cord-007788-09t52zix 517 18 80 80 CD cord-007788-09t52zix 517 19 % % NN cord-007788-09t52zix 517 20 ) ) -RRB- cord-007788-09t52zix 517 21 of of IN cord-007788-09t52zix 517 22 patients patient NNS cord-007788-09t52zix 517 23 , , , cord-007788-09t52zix 517 24 there there EX cord-007788-09t52zix 517 25 is be VBZ cord-007788-09t52zix 517 26 then then RB cord-007788-09t52zix 517 27 complete complete JJ cord-007788-09t52zix 517 28 resolution resolution NN cord-007788-09t52zix 517 29 in in IN cord-007788-09t52zix 517 30 less less JJR cord-007788-09t52zix 517 31 than than IN cord-007788-09t52zix 517 32 6 6 CD cord-007788-09t52zix 517 33 days day NNS cord-007788-09t52zix 517 34 . . . cord-007788-09t52zix 518 1 In in IN cord-007788-09t52zix 518 2 cases case NNS cord-007788-09t52zix 518 3 with with IN cord-007788-09t52zix 518 4 no no DT cord-007788-09t52zix 518 5 response response NN cord-007788-09t52zix 518 6 to to IN cord-007788-09t52zix 518 7 steroid steroid NN cord-007788-09t52zix 518 8 treatment treatment NN cord-007788-09t52zix 518 9 after after IN cord-007788-09t52zix 518 10 72 72 CD cord-007788-09t52zix 518 11 h h NN cord-007788-09t52zix 518 12 , , , cord-007788-09t52zix 518 13 biopsies biopsy NNS cord-007788-09t52zix 518 14 of of IN cord-007788-09t52zix 518 15 affected affected JJ cord-007788-09t52zix 518 16 organs organ NNS cord-007788-09t52zix 518 17 may may MD cord-007788-09t52zix 518 18 be be VB cord-007788-09t52zix 518 19 necessary necessary JJ cord-007788-09t52zix 518 20 . . . cord-007788-09t52zix 519 1 If if IN cord-007788-09t52zix 519 2 biopsies biopsy NNS cord-007788-09t52zix 519 3 are be VBP cord-007788-09t52zix 519 4 performed perform VBN cord-007788-09t52zix 519 5 for for IN cord-007788-09t52zix 519 6 evaluation evaluation NN cord-007788-09t52zix 519 7 of of IN cord-007788-09t52zix 519 8 diarrhoea diarrhoea NN cord-007788-09t52zix 519 9 , , , cord-007788-09t52zix 519 10 the the DT cord-007788-09t52zix 519 11 findings finding NNS cord-007788-09t52zix 519 12 may may MD cord-007788-09t52zix 519 13 not not RB cord-007788-09t52zix 519 14 be be VB cord-007788-09t52zix 519 15 able able JJ cord-007788-09t52zix 519 16 to to TO cord-007788-09t52zix 519 17 distinguish distinguish VB cord-007788-09t52zix 519 18 from from IN cord-007788-09t52zix 519 19 GvHD GvHD NNP cord-007788-09t52zix 519 20 . . . cord-007788-09t52zix 520 1 This this DT cord-007788-09t52zix 520 2 does do VBZ cord-007788-09t52zix 520 3 however however RB cord-007788-09t52zix 520 4 not not RB cord-007788-09t52zix 520 5 exclude exclude VB cord-007788-09t52zix 520 6 ES ES NNP cord-007788-09t52zix 520 7 since since IN cord-007788-09t52zix 520 8 overlap overlap NN cord-007788-09t52zix 520 9 and and CC cord-007788-09t52zix 520 10 coexistence coexistence NN cord-007788-09t52zix 520 11 with with IN cord-007788-09t52zix 520 12 GvHD GvHD NNP cord-007788-09t52zix 520 13 is be VBZ cord-007788-09t52zix 520 14 possible possible JJ cord-007788-09t52zix 520 15 . . . cord-007788-09t52zix 521 1 If if IN cord-007788-09t52zix 521 2 a a DT cord-007788-09t52zix 521 3 biopsy biopsy NN cord-007788-09t52zix 521 4 supports support VBZ cord-007788-09t52zix 521 5 the the DT cord-007788-09t52zix 521 6 ES ES NNP cord-007788-09t52zix 521 7 diagnosis diagnosis NN cord-007788-09t52zix 521 8 treatment treatment NN cord-007788-09t52zix 521 9 with with IN cord-007788-09t52zix 521 10 additional additional JJ cord-007788-09t52zix 521 11 immune immune JJ cord-007788-09t52zix 521 12 suppressants suppressant NNS cord-007788-09t52zix 521 13 should should MD cord-007788-09t52zix 521 14 be be VB cord-007788-09t52zix 521 15 started start VBN cord-007788-09t52zix 521 16 and and CC cord-007788-09t52zix 521 17 continued continue VBN cord-007788-09t52zix 521 18 until until IN cord-007788-09t52zix 521 19 response response NN cord-007788-09t52zix 521 20 . . . cord-007788-09t52zix 522 1 If if IN cord-007788-09t52zix 522 2 the the DT cord-007788-09t52zix 522 3 result result NN cord-007788-09t52zix 522 4 of of IN cord-007788-09t52zix 522 5 the the DT cord-007788-09t52zix 522 6 biopsy biopsy NN cord-007788-09t52zix 522 7 is be VBZ cord-007788-09t52zix 522 8 an an DT cord-007788-09t52zix 522 9 alternative alternative JJ cord-007788-09t52zix 522 10 diagnosis diagnosis NN cord-007788-09t52zix 522 11 , , , cord-007788-09t52zix 522 12 the the DT cord-007788-09t52zix 522 13 patient patient NN cord-007788-09t52zix 522 14 should should MD cord-007788-09t52zix 522 15 be be VB cord-007788-09t52zix 522 16 treated treat VBN cord-007788-09t52zix 522 17 accordingly accordingly RB cord-007788-09t52zix 522 18 . . . cord-007788-09t52zix 523 1 In in IN cord-007788-09t52zix 523 2 addition addition NN cord-007788-09t52zix 523 3 to to IN cord-007788-09t52zix 523 4 pharmacological pharmacological JJ cord-007788-09t52zix 523 5 treatment treatment NN cord-007788-09t52zix 523 6 supportive supportive JJ cord-007788-09t52zix 523 7 care care NN cord-007788-09t52zix 523 8 with with IN cord-007788-09t52zix 523 9 i.v i.v NNP cord-007788-09t52zix 523 10 . . . cord-007788-09t52zix 523 11 fluids fluid NNS cord-007788-09t52zix 523 12 , , , cord-007788-09t52zix 523 13 with with IN cord-007788-09t52zix 523 14 electrolyte electrolyte JJ cord-007788-09t52zix 523 15 supplement supplement NN cord-007788-09t52zix 523 16 as as IN cord-007788-09t52zix 523 17 needed need VBN cord-007788-09t52zix 523 18 , , , cord-007788-09t52zix 523 19 and and CC cord-007788-09t52zix 523 20 oxygen oxygen NN cord-007788-09t52zix 523 21 therapy therapy NN cord-007788-09t52zix 523 22 may may MD cord-007788-09t52zix 523 23 be be VB cord-007788-09t52zix 523 24 necessary necessary JJ cord-007788-09t52zix 523 25 depending depend VBG cord-007788-09t52zix 523 26 on on IN cord-007788-09t52zix 523 27 the the DT cord-007788-09t52zix 523 28 symptoms symptom NNS cord-007788-09t52zix 523 29 . . . cord-007788-09t52zix 524 1 In in IN cord-007788-09t52zix 524 2 cases case NNS cord-007788-09t52zix 524 3 of of IN cord-007788-09t52zix 524 4 encephalopathy encephalopathy NN cord-007788-09t52zix 524 5 or or CC cord-007788-09t52zix 524 6 severe severe JJ cord-007788-09t52zix 524 7 ES es NN cord-007788-09t52zix 524 8 with with IN cord-007788-09t52zix 524 9 MOF MOF NNP cord-007788-09t52zix 524 10 , , , cord-007788-09t52zix 524 11 plasma plasma NN cord-007788-09t52zix 524 12 exchange exchange NN cord-007788-09t52zix 524 13 may may MD cord-007788-09t52zix 524 14 be be VB cord-007788-09t52zix 524 15 considered consider VBN cord-007788-09t52zix 524 16 ( ( -LRB- cord-007788-09t52zix 524 17 Yeoung Yeoung NNP cord-007788-09t52zix 524 18 - - HYPH cord-007788-09t52zix 524 19 Hau Hau NNP cord-007788-09t52zix 524 20 and and CC cord-007788-09t52zix 524 21 Syed Syed NNP cord-007788-09t52zix 524 22 2014 2014 CD cord-007788-09t52zix 524 23 ) ) -RRB- cord-007788-09t52zix 524 24 . . . cord-007788-09t52zix 525 1 Daily daily JJ cord-007788-09t52zix 525 2 nursing nursing NN cord-007788-09t52zix 525 3 assessments assessment NNS cord-007788-09t52zix 525 4 are be VBP cord-007788-09t52zix 525 5 critical critical JJ cord-007788-09t52zix 525 6 in in IN cord-007788-09t52zix 525 7 early early JJ cord-007788-09t52zix 525 8 detection detection NN cord-007788-09t52zix 525 9 and and CC cord-007788-09t52zix 525 10 diagnosis diagnosis NN cord-007788-09t52zix 525 11 of of IN cord-007788-09t52zix 525 12 all all DT cord-007788-09t52zix 525 13 complications complication NNS cord-007788-09t52zix 525 14 to to IN cord-007788-09t52zix 525 15 HSCT HSCT NNP cord-007788-09t52zix 525 16 . . . cord-007788-09t52zix 526 1 The the DT cord-007788-09t52zix 526 2 patient patient NN cord-007788-09t52zix 526 3 's 's POS cord-007788-09t52zix 526 4 general general JJ cord-007788-09t52zix 526 5 well well NN cord-007788-09t52zix 526 6 - - HYPH cord-007788-09t52zix 526 7 being being NN cord-007788-09t52zix 526 8 should should MD cord-007788-09t52zix 526 9 be be VB cord-007788-09t52zix 526 10 assessed assess VBN cord-007788-09t52zix 526 11 , , , cord-007788-09t52zix 526 12 and and CC cord-007788-09t52zix 526 13 listed list VBN cord-007788-09t52zix 526 14 below below RB cord-007788-09t52zix 526 15 are be VBP cord-007788-09t52zix 526 16 the the DT cord-007788-09t52zix 526 17 nursing nursing NN cord-007788-09t52zix 526 18 assessments assessment NNS cord-007788-09t52zix 526 19 that that WDT cord-007788-09t52zix 526 20 should should MD cord-007788-09t52zix 526 21 be be VB cord-007788-09t52zix 526 22 carried carry VBN cord-007788-09t52zix 526 23 out out RP cord-007788-09t52zix 526 24 frequently frequently RB cord-007788-09t52zix 526 25 , , , cord-007788-09t52zix 526 26 the the DT cord-007788-09t52zix 526 27 findings finding NNS cord-007788-09t52zix 526 28 that that WDT cord-007788-09t52zix 526 29 could could MD cord-007788-09t52zix 526 30 indicate indicate VB cord-007788-09t52zix 526 31 ES ES NNP cord-007788-09t52zix 526 32 and and CC cord-007788-09t52zix 526 33 actions action NNS cord-007788-09t52zix 526 34 that that WDT cord-007788-09t52zix 526 35 can can MD cord-007788-09t52zix 526 36 be be VB cord-007788-09t52zix 526 37 taken take VBN cord-007788-09t52zix 526 38 in in IN cord-007788-09t52zix 526 39 order order NN cord-007788-09t52zix 526 40 to to TO cord-007788-09t52zix 526 41 detect detect VB cord-007788-09t52zix 526 42 or or CC cord-007788-09t52zix 526 43 rule rule VB cord-007788-09t52zix 526 44 out out RP cord-007788-09t52zix 526 45 the the DT cord-007788-09t52zix 526 46 ES es NN cord-007788-09t52zix 526 47 diagnosis diagnosis NN cord-007788-09t52zix 526 48 ( ( -LRB- cord-007788-09t52zix 526 49 Table table NN cord-007788-09t52zix 526 50 9 9 CD cord-007788-09t52zix 526 51 .9 .9 CD cord-007788-09t52zix 526 52 ) ) -RRB- cord-007788-09t52zix 526 53 . . . cord-007788-09t52zix 527 1 All all DT cord-007788-09t52zix 527 2 findings finding NNS cord-007788-09t52zix 527 3 should should MD cord-007788-09t52zix 527 4 be be VB cord-007788-09t52zix 527 5 Monitor Monitor NNP cord-007788-09t52zix 527 6 frequently frequently RB cord-007788-09t52zix 527 7 , , , cord-007788-09t52zix 527 8 and and CC cord-007788-09t52zix 527 9 if if IN cord-007788-09t52zix 527 10 symptoms symptom NNS cord-007788-09t52zix 527 11 of of IN cord-007788-09t52zix 527 12 pulmonary pulmonary JJ cord-007788-09t52zix 527 13 dysfunction dysfunction NN cord-007788-09t52zix 527 14 , , , cord-007788-09t52zix 527 15 e.g. e.g. RB cord-007788-09t52zix 527 16 dyspnoea dyspnoea NNS cord-007788-09t52zix 527 17 , , , cord-007788-09t52zix 527 18 tachypnoea tachypnoea NNS cord-007788-09t52zix 527 19 , , , cord-007788-09t52zix 527 20 change change VBP cord-007788-09t52zix 527 21 in in IN cord-007788-09t52zix 527 22 breathing breathing NN cord-007788-09t52zix 527 23 pattern pattern NN cord-007788-09t52zix 527 24 , , , cord-007788-09t52zix 527 25 chest chest NN cord-007788-09t52zix 527 26 pain pain NN cord-007788-09t52zix 527 27 or or CC cord-007788-09t52zix 527 28 cough cough NN cord-007788-09t52zix 527 29 , , , cord-007788-09t52zix 527 30 are be VBP cord-007788-09t52zix 527 31 present present JJ cord-007788-09t52zix 527 32 , , , cord-007788-09t52zix 527 33 a a DT cord-007788-09t52zix 527 34 chest chest NN cord-007788-09t52zix 527 35 X x NN cord-007788-09t52zix 527 36 - - NN cord-007788-09t52zix 527 37 ray ray NN cord-007788-09t52zix 527 38 or or CC cord-007788-09t52zix 527 39 pulmonary pulmonary JJ cord-007788-09t52zix 527 40 CT ct NN cord-007788-09t52zix 527 41 scan scan NN cord-007788-09t52zix 527 42 may may MD cord-007788-09t52zix 527 43 be be VB cord-007788-09t52zix 527 44 performed perform VBN cord-007788-09t52zix 527 45 . . . cord-007788-09t52zix 528 1 In in IN cord-007788-09t52zix 528 2 order order NN cord-007788-09t52zix 528 3 to to TO cord-007788-09t52zix 528 4 ensure ensure VB cord-007788-09t52zix 528 5 adequate adequate JJ cord-007788-09t52zix 528 6 oxygenation oxygenation NN cord-007788-09t52zix 528 7 , , , cord-007788-09t52zix 528 8 administration administration NN cord-007788-09t52zix 528 9 of of IN cord-007788-09t52zix 528 10 oxygen oxygen NN cord-007788-09t52zix 528 11 therapy therapy NN cord-007788-09t52zix 528 12 may may MD cord-007788-09t52zix 528 13 be be VB cord-007788-09t52zix 528 14 necessary necessary JJ cord-007788-09t52zix 528 15 Weight weight NN cord-007788-09t52zix 528 16 and and CC cord-007788-09t52zix 528 17 fluid fluid JJ cord-007788-09t52zix 528 18 balance balance NN cord-007788-09t52zix 528 19 Assess assess VBP cord-007788-09t52zix 528 20 the the DT cord-007788-09t52zix 528 21 patient patient NN cord-007788-09t52zix 528 22 's 's POS cord-007788-09t52zix 528 23 weight weight NN cord-007788-09t52zix 528 24 daily daily RB cord-007788-09t52zix 528 25 and and CC cord-007788-09t52zix 528 26 perform perform VB cord-007788-09t52zix 528 27 calculation calculation NN cord-007788-09t52zix 528 28 of of IN cord-007788-09t52zix 528 29 fluid fluid JJ cord-007788-09t52zix 528 30 balance balance NN cord-007788-09t52zix 528 31 at at IN cord-007788-09t52zix 528 32 least least JJS cord-007788-09t52zix 528 33 once once RB cord-007788-09t52zix 528 34 daily daily RB cord-007788-09t52zix 528 35 to to TO cord-007788-09t52zix 528 36 note note VB cord-007788-09t52zix 528 37 any any DT cord-007788-09t52zix 528 38 trends trend NNS cord-007788-09t52zix 528 39 . . . cord-007788-09t52zix 529 1 If if IN cord-007788-09t52zix 529 2 oedema oedema NN cord-007788-09t52zix 529 3 , , , cord-007788-09t52zix 529 4 ascites ascites NN cord-007788-09t52zix 529 5 or or CC cord-007788-09t52zix 529 6 other other JJ cord-007788-09t52zix 529 7 symptoms symptom NNS cord-007788-09t52zix 529 8 of of IN cord-007788-09t52zix 529 9 fluid fluid JJ cord-007788-09t52zix 529 10 retention retention NN cord-007788-09t52zix 529 11 occurs occur VBZ cord-007788-09t52zix 529 12 diuretics diuretic NNS cord-007788-09t52zix 529 13 should should MD cord-007788-09t52zix 529 14 be be VB cord-007788-09t52zix 529 15 administered administer VBN cord-007788-09t52zix 529 16 as as IN cord-007788-09t52zix 529 17 ordered order VBN cord-007788-09t52zix 529 18 Skin skin NN cord-007788-09t52zix 529 19 Perform Perform NNP cord-007788-09t52zix 529 20 assessment assessment NN cord-007788-09t52zix 529 21 at at IN cord-007788-09t52zix 529 22 least least JJS cord-007788-09t52zix 529 23 daily daily RB cord-007788-09t52zix 529 24 and and CC cord-007788-09t52zix 529 25 note note VB cord-007788-09t52zix 529 26 any any DT cord-007788-09t52zix 529 27 rashes rash NNS cord-007788-09t52zix 529 28 . . . cord-007788-09t52zix 530 1 If if IN cord-007788-09t52zix 530 2 a a DT cord-007788-09t52zix 530 3 rash rash NN cord-007788-09t52zix 530 4 is be VBZ cord-007788-09t52zix 530 5 detected detect VBN cord-007788-09t52zix 530 6 , , , cord-007788-09t52zix 530 7 review review VB cord-007788-09t52zix 530 8 the the DT cord-007788-09t52zix 530 9 patient patient NN cord-007788-09t52zix 530 10 's 's POS cord-007788-09t52zix 530 11 medication medication NN cord-007788-09t52zix 530 12 chart chart NN cord-007788-09t52zix 530 13 for for IN cord-007788-09t52zix 530 14 medication medication NN cord-007788-09t52zix 530 15 that that WDT cord-007788-09t52zix 530 16 may may MD cord-007788-09t52zix 530 17 cause cause VB cord-007788-09t52zix 530 18 drug drug NN cord-007788-09t52zix 530 19 rash rash NN cord-007788-09t52zix 530 20 Jaundice jaundice NN cord-007788-09t52zix 530 21 and and CC cord-007788-09t52zix 530 22 yellow yellow JJ cord-007788-09t52zix 530 23 sclera sclera NN cord-007788-09t52zix 530 24 are be VBP cord-007788-09t52zix 530 25 signs sign NNS cord-007788-09t52zix 530 26 of of IN cord-007788-09t52zix 530 27 liver liver NN cord-007788-09t52zix 530 28 dysfunction dysfunction NN cord-007788-09t52zix 530 29 and and CC cord-007788-09t52zix 530 30 bilirubin bilirubin NN cord-007788-09t52zix 530 31 levels level NNS cord-007788-09t52zix 530 32 should should MD cord-007788-09t52zix 530 33 be be VB cord-007788-09t52zix 530 34 checked check VBN cord-007788-09t52zix 530 35 Stools stool NNS cord-007788-09t52zix 530 36 Monitor Monitor NNP cord-007788-09t52zix 530 37 frequency frequency NN cord-007788-09t52zix 530 38 and and CC cord-007788-09t52zix 530 39 consistency consistency NN cord-007788-09t52zix 530 40 and and CC cord-007788-09t52zix 530 41 obtain obtain VB cord-007788-09t52zix 530 42 cultures culture NNS cord-007788-09t52zix 530 43 and and CC cord-007788-09t52zix 530 44 test test NN cord-007788-09t52zix 530 45 for for IN cord-007788-09t52zix 530 46 Clostridium clostridium NN cord-007788-09t52zix 530 47 difficile difficile NN cord-007788-09t52zix 530 48 in in IN cord-007788-09t52zix 530 49 cases case NNS cord-007788-09t52zix 530 50 of of IN cord-007788-09t52zix 530 51 diarrhoea diarrhoea NN cord-007788-09t52zix 530 52 in in IN cord-007788-09t52zix 530 53 order order NN cord-007788-09t52zix 530 54 to to TO cord-007788-09t52zix 530 55 rule rule VB cord-007788-09t52zix 530 56 out out RP cord-007788-09t52zix 530 57 infection infection NN cord-007788-09t52zix 530 58 . . . cord-007788-09t52zix 531 1 Pale pale JJ cord-007788-09t52zix 531 2 stools stool NNS cord-007788-09t52zix 531 3 are be VBP cord-007788-09t52zix 531 4 a a DT cord-007788-09t52zix 531 5 sign sign NN cord-007788-09t52zix 531 6 of of IN cord-007788-09t52zix 531 7 liver liver NN cord-007788-09t52zix 531 8 dysfunction dysfunction NN cord-007788-09t52zix 531 9 and and CC cord-007788-09t52zix 531 10 bilirubin bilirubin NN cord-007788-09t52zix 531 11 levels level NNS cord-007788-09t52zix 531 12 should should MD cord-007788-09t52zix 531 13 be be VB cord-007788-09t52zix 531 14 checked check VBN cord-007788-09t52zix 531 15 ( ( -LRB- cord-007788-09t52zix 531 16 continued continue VBN cord-007788-09t52zix 531 17 ) ) -RRB- cord-007788-09t52zix 531 18 documented document VBN cord-007788-09t52zix 531 19 and and CC cord-007788-09t52zix 531 20 any any DT cord-007788-09t52zix 531 21 abnormalities abnormality NNS cord-007788-09t52zix 531 22 promptly promptly RB cord-007788-09t52zix 531 23 reported report VBD cord-007788-09t52zix 531 24 to to IN cord-007788-09t52zix 531 25 the the DT cord-007788-09t52zix 531 26 treating treat VBG cord-007788-09t52zix 531 27 physician physician NN cord-007788-09t52zix 531 28 . . . cord-007788-09t52zix 532 1 If if IN cord-007788-09t52zix 532 2 steroid steroid NN cord-007788-09t52zix 532 3 treatment treatment NN cord-007788-09t52zix 532 4 is be VBZ cord-007788-09t52zix 532 5 started start VBN cord-007788-09t52zix 532 6 , , , cord-007788-09t52zix 532 7 the the DT cord-007788-09t52zix 532 8 patient patient NN cord-007788-09t52zix 532 9 should should MD cord-007788-09t52zix 532 10 be be VB cord-007788-09t52zix 532 11 assessed assess VBN cord-007788-09t52zix 532 12 for for IN cord-007788-09t52zix 532 13 possible possible JJ cord-007788-09t52zix 532 14 side side NN cord-007788-09t52zix 532 15 effects effect NNS cord-007788-09t52zix 532 16 such such JJ cord-007788-09t52zix 532 17 as as IN cord-007788-09t52zix 532 18 hyperglycaemia hyperglycaemia NN cord-007788-09t52zix 532 19 and and CC cord-007788-09t52zix 532 20 insomnia insomnia NN cord-007788-09t52zix 532 21 . . . cord-007788-09t52zix 533 1 Blood blood NN cord-007788-09t52zix 533 2 glucose glucose NN cord-007788-09t52zix 533 3 should should MD cord-007788-09t52zix 533 4 be be VB cord-007788-09t52zix 533 5 monitored monitor VBN cord-007788-09t52zix 533 6 daily daily RB cord-007788-09t52zix 533 7 . . . cord-007788-09t52zix 534 1 Idiopathic idiopathic JJ cord-007788-09t52zix 534 2 Pneumonia Pneumonia NNP cord-007788-09t52zix 534 3 Syndrome Syndrome NNP cord-007788-09t52zix 534 4 Pulmonary Pulmonary NNP cord-007788-09t52zix 534 5 complications complication NNS cord-007788-09t52zix 534 6 ( ( -LRB- cord-007788-09t52zix 534 7 PCs pc NNS cord-007788-09t52zix 534 8 ) ) -RRB- cord-007788-09t52zix 534 9 are be VBP cord-007788-09t52zix 534 10 the the DT cord-007788-09t52zix 534 11 leading leading JJ cord-007788-09t52zix 534 12 cause cause NN cord-007788-09t52zix 534 13 of of IN cord-007788-09t52zix 534 14 patients patient NNS cord-007788-09t52zix 534 15 ' ' POS cord-007788-09t52zix 534 16 admission admission NN cord-007788-09t52zix 534 17 to to IN cord-007788-09t52zix 534 18 intensive intensive JJ cord-007788-09t52zix 534 19 care care NN cord-007788-09t52zix 534 20 unit unit NN cord-007788-09t52zix 534 21 ( ( -LRB- cord-007788-09t52zix 534 22 ICU ICU NNP cord-007788-09t52zix 534 23 ) ) -RRB- cord-007788-09t52zix 534 24 after after IN cord-007788-09t52zix 534 25 HSCT HSCT NNP cord-007788-09t52zix 534 26 . . . cord-007788-09t52zix 535 1 PC pc NN cord-007788-09t52zix 535 2 can can MD cord-007788-09t52zix 535 3 be be VB cord-007788-09t52zix 535 4 divided divide VBN cord-007788-09t52zix 535 5 into into IN cord-007788-09t52zix 535 6 infectious infectious JJ cord-007788-09t52zix 535 7 or or CC cord-007788-09t52zix 535 8 non non JJ cord-007788-09t52zix 535 9 - - JJ cord-007788-09t52zix 535 10 infectious infectious JJ cord-007788-09t52zix 535 11 . . . cord-007788-09t52zix 536 1 One one CD cord-007788-09t52zix 536 2 of of IN cord-007788-09t52zix 536 3 the the DT cord-007788-09t52zix 536 4 non non JJ cord-007788-09t52zix 536 5 - - JJ cord-007788-09t52zix 536 6 infectious infectious JJ cord-007788-09t52zix 536 7 PCs pc NNS cord-007788-09t52zix 536 8 is be VBZ cord-007788-09t52zix 536 9 idiopathic idiopathic JJ cord-007788-09t52zix 536 10 pneumonia pneumonia NN cord-007788-09t52zix 536 11 syndrome syndrome NN cord-007788-09t52zix 536 12 ( ( -LRB- cord-007788-09t52zix 536 13 IPS IPS NNP cord-007788-09t52zix 536 14 ) ) -RRB- cord-007788-09t52zix 536 15 . . . cord-007788-09t52zix 537 1 For for IN cord-007788-09t52zix 537 2 the the DT cord-007788-09t52zix 537 3 purpose purpose NN cord-007788-09t52zix 537 4 of of IN cord-007788-09t52zix 537 5 this this DT cord-007788-09t52zix 537 6 chapter chapter NN cord-007788-09t52zix 537 7 , , , cord-007788-09t52zix 537 8 IPS IPS NNP cord-007788-09t52zix 537 9 will will MD cord-007788-09t52zix 537 10 be be VB cord-007788-09t52zix 537 11 defined define VBN cord-007788-09t52zix 537 12 and and CC cord-007788-09t52zix 537 13 described describe VBN cord-007788-09t52zix 537 14 according accord VBG cord-007788-09t52zix 537 15 to to IN cord-007788-09t52zix 537 16 the the DT cord-007788-09t52zix 537 17 definition definition NN cord-007788-09t52zix 537 18 by by IN cord-007788-09t52zix 537 19 the the DT cord-007788-09t52zix 537 20 American American NNP cord-007788-09t52zix 537 21 Thoracic Thoracic NNP cord-007788-09t52zix 537 22 Society Society NNP cord-007788-09t52zix 538 1 ( ( -LRB- cord-007788-09t52zix 538 2 Panotskaltsis Panotskaltsis NNP cord-007788-09t52zix 538 3 - - HYPH cord-007788-09t52zix 538 4 Mortari Mortari NNP cord-007788-09t52zix 538 5 et et NNP cord-007788-09t52zix 538 6 al al NNP cord-007788-09t52zix 538 7 . . NNP cord-007788-09t52zix 538 8 2011 2011 CD cord-007788-09t52zix 538 9 ) ) -RRB- cord-007788-09t52zix 538 10 as as IN cord-007788-09t52zix 538 11 " " `` cord-007788-09t52zix 538 12 an an DT cord-007788-09t52zix 538 13 idiopathic idiopathic JJ cord-007788-09t52zix 538 14 syndrome syndrome NN cord-007788-09t52zix 538 15 of of IN cord-007788-09t52zix 538 16 pneumopathy pneumopathy NNP cord-007788-09t52zix 538 17 after after IN cord-007788-09t52zix 538 18 HSCT HSCT NNP cord-007788-09t52zix 538 19 , , , cord-007788-09t52zix 538 20 with with IN cord-007788-09t52zix 538 21 evidence evidence NN cord-007788-09t52zix 538 22 of of IN cord-007788-09t52zix 538 23 widespread widespread JJ cord-007788-09t52zix 538 24 alveolar alveolar JJ cord-007788-09t52zix 538 25 injury injury NN cord-007788-09t52zix 538 26 and and CC cord-007788-09t52zix 538 27 in in IN cord-007788-09t52zix 538 28 which which WDT cord-007788-09t52zix 538 29 an an DT cord-007788-09t52zix 538 30 infectious infectious JJ cord-007788-09t52zix 538 31 etiology etiology NN cord-007788-09t52zix 538 32 and and CC cord-007788-09t52zix 538 33 cardiac cardiac JJ cord-007788-09t52zix 538 34 dysfunction dysfunction NN cord-007788-09t52zix 538 35 , , , cord-007788-09t52zix 538 36 acute acute JJ cord-007788-09t52zix 538 37 renal renal JJ cord-007788-09t52zix 538 38 failure failure NN cord-007788-09t52zix 538 39 or or CC cord-007788-09t52zix 538 40 iatrogenic iatrogenic JJ cord-007788-09t52zix 538 41 fluid fluid JJ cord-007788-09t52zix 538 42 overload overload NN cord-007788-09t52zix 538 43 have have VBP cord-007788-09t52zix 538 44 been be VBN cord-007788-09t52zix 538 45 excluded exclude VBN cord-007788-09t52zix 538 46 " " '' cord-007788-09t52zix 538 47 . . . cord-007788-09t52zix 539 1 The the DT cord-007788-09t52zix 539 2 alveolar alveolar JJ cord-007788-09t52zix 539 3 injury injury NN cord-007788-09t52zix 539 4 is be VBZ cord-007788-09t52zix 539 5 a a DT cord-007788-09t52zix 539 6 result result NN cord-007788-09t52zix 539 7 from from IN cord-007788-09t52zix 539 8 the the DT cord-007788-09t52zix 539 9 release release NN cord-007788-09t52zix 539 10 of of IN cord-007788-09t52zix 539 11 proinflammatory proinflammatory JJ cord-007788-09t52zix 539 12 cytokines cytokine NNS cord-007788-09t52zix 539 13 during during IN cord-007788-09t52zix 539 14 engraftment engraftment NN cord-007788-09t52zix 539 15 increasing increase VBG cord-007788-09t52zix 539 16 alveolar alveolar JJ cord-007788-09t52zix 539 17 permeability permeability NN cord-007788-09t52zix 539 18 and and CC cord-007788-09t52zix 539 19 causing cause VBG cord-007788-09t52zix 539 20 diffuse diffuse JJ cord-007788-09t52zix 539 21 alveolar alveolar NN cord-007788-09t52zix 539 22 or or CC cord-007788-09t52zix 539 23 interstitial interstitial JJ cord-007788-09t52zix 539 24 infiltrates infiltrate NNS cord-007788-09t52zix 539 25 . . . cord-007788-09t52zix 540 1 IPS IPS NNP cord-007788-09t52zix 540 2 also also RB cord-007788-09t52zix 540 3 includes include VBZ cord-007788-09t52zix 540 4 a a DT cord-007788-09t52zix 540 5 subset subset NN cord-007788-09t52zix 540 6 of of IN cord-007788-09t52zix 540 7 diagnoses diagnosis NNS cord-007788-09t52zix 540 8 of of IN cord-007788-09t52zix 540 9 primary primary JJ cord-007788-09t52zix 540 10 lung lung NN cord-007788-09t52zix 540 11 injuries injury NNS cord-007788-09t52zix 540 12 classified classify VBD cord-007788-09t52zix 540 13 according accord VBG cord-007788-09t52zix 540 14 to to IN cord-007788-09t52zix 540 15 the the DT cord-007788-09t52zix 540 16 anatomical anatomical JJ cord-007788-09t52zix 540 17 sites site NNS cord-007788-09t52zix 540 18 of of IN cord-007788-09t52zix 540 19 inflammation inflammation NN cord-007788-09t52zix 540 20 . . . cord-007788-09t52zix 541 1 They -PRON- PRP cord-007788-09t52zix 541 2 can can MD cord-007788-09t52zix 541 3 either either CC cord-007788-09t52zix 541 4 be be VB cord-007788-09t52zix 541 5 related relate VBN cord-007788-09t52zix 541 6 to to IN cord-007788-09t52zix 541 7 the the DT cord-007788-09t52zix 541 8 pulmonary pulmonary JJ cord-007788-09t52zix 541 9 parenchyma parenchyma NN cord-007788-09t52zix 541 10 ( ( -LRB- cord-007788-09t52zix 541 11 e.g. e.g. DT cord-007788-09t52zix 541 12 acute acute JJ cord-007788-09t52zix 541 13 interstitial interstitial JJ cord-007788-09t52zix 541 14 pneumonitis pneumonitis NN cord-007788-09t52zix 541 15 and and CC cord-007788-09t52zix 541 16 acute acute JJ cord-007788-09t52zix 541 17 respiratory respiratory JJ cord-007788-09t52zix 541 18 distress distress NN cord-007788-09t52zix 541 19 syndrome syndrome NN cord-007788-09t52zix 541 20 ( ( -LRB- cord-007788-09t52zix 541 21 ARDS ARDS NNP cord-007788-09t52zix 541 22 ) ) -RRB- cord-007788-09t52zix 541 23 ) ) -RRB- cord-007788-09t52zix 541 24 , , , cord-007788-09t52zix 541 25 the the DT cord-007788-09t52zix 541 26 airway airway NN cord-007788-09t52zix 541 27 endothelium endothelium NN cord-007788-09t52zix 541 28 ( ( -LRB- cord-007788-09t52zix 541 29 e.g. e.g. IN cord-007788-09t52zix 541 30 bronchiolitis bronchiolitis NNP cord-007788-09t52zix 541 31 obliterans obliterans NNP cord-007788-09t52zix 541 32 syndrome syndrome NN cord-007788-09t52zix 541 33 ( ( -LRB- cord-007788-09t52zix 541 34 BO BO NNP cord-007788-09t52zix 541 35 ) ) -RRB- cord-007788-09t52zix 541 36 ) ) -RRB- cord-007788-09t52zix 541 37 , , , cord-007788-09t52zix 541 38 the the DT cord-007788-09t52zix 541 39 vascular vascular JJ cord-007788-09t52zix 541 40 endothelium endothelium NN cord-007788-09t52zix 541 41 ( ( -LRB- cord-007788-09t52zix 541 42 e.g. e.g. RB cord-007788-09t52zix 541 43 different different JJ cord-007788-09t52zix 541 44 forms form NNS cord-007788-09t52zix 541 45 of of IN cord-007788-09t52zix 541 46 ES ES NNP cord-007788-09t52zix 541 47 ( ( -LRB- cord-007788-09t52zix 541 48 PERDS PERDS NNP cord-007788-09t52zix 541 49 , , , cord-007788-09t52zix 541 50 CLS CLS NNP cord-007788-09t52zix 541 51 ) ) -RRB- cord-007788-09t52zix 541 52 ) ) -RRB- cord-007788-09t52zix 541 53 or or CC cord-007788-09t52zix 541 54 be be VB cord-007788-09t52zix 541 55 unclassifiable unclassifiable JJ cord-007788-09t52zix 541 56 . . . cord-007788-09t52zix 542 1 Other other JJ cord-007788-09t52zix 542 2 less less RBR cord-007788-09t52zix 542 3 frequent frequent JJ cord-007788-09t52zix 542 4 non non JJ cord-007788-09t52zix 542 5 - - JJ cord-007788-09t52zix 542 6 infectious infectious JJ cord-007788-09t52zix 542 7 PCs pc NNS cord-007788-09t52zix 542 8 have have VBP cord-007788-09t52zix 542 9 also also RB cord-007788-09t52zix 542 10 been be VBN cord-007788-09t52zix 542 11 identified identify VBN cord-007788-09t52zix 542 12 . . . cord-007788-09t52zix 543 1 None none NN cord-007788-09t52zix 543 2 of of IN cord-007788-09t52zix 543 3 these these DT cord-007788-09t52zix 543 4 entities entity NNS cord-007788-09t52zix 543 5 will will MD cord-007788-09t52zix 543 6 be be VB cord-007788-09t52zix 543 7 described describe VBN cord-007788-09t52zix 543 8 here here RB cord-007788-09t52zix 543 9 . . . cord-007788-09t52zix 544 1 PCs pc NNS cord-007788-09t52zix 544 2 are be VBP cord-007788-09t52zix 544 3 common common JJ cord-007788-09t52zix 544 4 in in IN cord-007788-09t52zix 544 5 HSCT HSCT NNP cord-007788-09t52zix 544 6 recipients recipient NNS cord-007788-09t52zix 544 7 and and CC cord-007788-09t52zix 544 8 a a DT cord-007788-09t52zix 544 9 major major JJ cord-007788-09t52zix 544 10 cause cause NN cord-007788-09t52zix 544 11 of of IN cord-007788-09t52zix 544 12 morbidity morbidity NN cord-007788-09t52zix 544 13 and and CC cord-007788-09t52zix 544 14 mortality mortality NN cord-007788-09t52zix 544 15 . . . cord-007788-09t52zix 545 1 IPS IPS NNP cord-007788-09t52zix 545 2 is be VBZ cord-007788-09t52zix 545 3 more more RBR cord-007788-09t52zix 545 4 often often RB cord-007788-09t52zix 545 5 seen see VBN cord-007788-09t52zix 545 6 in in IN cord-007788-09t52zix 545 7 patients patient NNS cord-007788-09t52zix 545 8 undergoing undergo VBG cord-007788-09t52zix 545 9 allogeneic allogeneic IN cord-007788-09t52zix 545 10 HSCT HSCT NNP cord-007788-09t52zix 545 11 with with IN cord-007788-09t52zix 545 12 a a DT cord-007788-09t52zix 545 13 mean mean JJ cord-007788-09t52zix 545 14 estimated estimate VBN cord-007788-09t52zix 545 15 incidence incidence NN cord-007788-09t52zix 545 16 of of IN cord-007788-09t52zix 545 17 1 1 CD cord-007788-09t52zix 545 18 - - SYM cord-007788-09t52zix 545 19 10 10 CD cord-007788-09t52zix 545 20 % % NN cord-007788-09t52zix 545 21 ( ( -LRB- cord-007788-09t52zix 545 22 6 6 CD cord-007788-09t52zix 545 23 % % NN cord-007788-09t52zix 545 24 in in IN cord-007788-09t52zix 545 25 auto auto NN cord-007788-09t52zix 545 26 - - HYPH cord-007788-09t52zix 545 27 HSCT HSCT NNP cord-007788-09t52zix 545 28 ) ) -RRB- cord-007788-09t52zix 546 1 ( ( -LRB- cord-007788-09t52zix 546 2 Chi Chi NNP cord-007788-09t52zix 546 3 et et NNP cord-007788-09t52zix 546 4 al al NNP cord-007788-09t52zix 546 5 . . NNP cord-007788-09t52zix 546 6 2013 2013 CD cord-007788-09t52zix 546 7 ) ) -RRB- cord-007788-09t52zix 546 8 . . . cord-007788-09t52zix 547 1 The the DT cord-007788-09t52zix 547 2 overall overall JJ cord-007788-09t52zix 547 3 outcome outcome NN cord-007788-09t52zix 547 4 is be VBZ cord-007788-09t52zix 547 5 different different JJ cord-007788-09t52zix 547 6 between between IN cord-007788-09t52zix 547 7 auto auto NN cord-007788-09t52zix 547 8 - - : cord-007788-09t52zix 547 9 and and CC cord-007788-09t52zix 547 10 allo allo NN cord-007788-09t52zix 547 11 - - HYPH cord-007788-09t52zix 547 12 HSCT HSCT NNP cord-007788-09t52zix 547 13 recipients recipient NNS cord-007788-09t52zix 547 14 , , , cord-007788-09t52zix 547 15 and and CC cord-007788-09t52zix 547 16 where where WRB cord-007788-09t52zix 547 17 IPS IPS NNP cord-007788-09t52zix 547 18 in in IN cord-007788-09t52zix 547 19 patients patient NNS cord-007788-09t52zix 547 20 that that WDT cord-007788-09t52zix 547 21 have have VBP cord-007788-09t52zix 547 22 undergone undergo VBN cord-007788-09t52zix 547 23 auto auto NN cord-007788-09t52zix 547 24 - - HYPH cord-007788-09t52zix 547 25 HSCT HSCT NNP cord-007788-09t52zix 547 26 usually usually RB cord-007788-09t52zix 547 27 has have VBZ cord-007788-09t52zix 547 28 a a DT cord-007788-09t52zix 547 29 favourable favourable JJ cord-007788-09t52zix 547 30 prognosis prognosis NN cord-007788-09t52zix 547 31 , , , cord-007788-09t52zix 547 32 the the DT cord-007788-09t52zix 547 33 mortality mortality NN cord-007788-09t52zix 547 34 is be VBZ cord-007788-09t52zix 547 35 60 60 CD cord-007788-09t52zix 547 36 - - SYM cord-007788-09t52zix 547 37 80 80 CD cord-007788-09t52zix 547 38 % % NN cord-007788-09t52zix 547 39 in in IN cord-007788-09t52zix 547 40 the the DT cord-007788-09t52zix 547 41 allo allo NN cord-007788-09t52zix 547 42 - - HYPH cord-007788-09t52zix 547 43 setting setting NN cord-007788-09t52zix 547 44 ( ( -LRB- cord-007788-09t52zix 547 45 Carreras Carreras NNP cord-007788-09t52zix 547 46 2012 2012 CD cord-007788-09t52zix 547 47 ) ) -RRB- cord-007788-09t52zix 547 48 . . . cord-007788-09t52zix 548 1 IPS IPS NNP cord-007788-09t52zix 548 2 has have VBZ cord-007788-09t52zix 548 3 a a DT cord-007788-09t52zix 548 4 progressive progressive JJ cord-007788-09t52zix 548 5 nature nature NN cord-007788-09t52zix 548 6 , , , cord-007788-09t52zix 548 7 and and CC cord-007788-09t52zix 548 8 patients patient NNS cord-007788-09t52zix 548 9 with with IN cord-007788-09t52zix 548 10 progression progression NN cord-007788-09t52zix 548 11 to to IN cord-007788-09t52zix 548 12 respiratory respiratory JJ cord-007788-09t52zix 548 13 failure failure NN cord-007788-09t52zix 548 14 and and CC cord-007788-09t52zix 548 15 need need NN cord-007788-09t52zix 548 16 for for IN cord-007788-09t52zix 548 17 mechanical mechanical JJ cord-007788-09t52zix 548 18 ventilation ventilation NN cord-007788-09t52zix 548 19 have have VBP cord-007788-09t52zix 548 20 a a DT cord-007788-09t52zix 548 21 very very RB cord-007788-09t52zix 548 22 poor poor JJ cord-007788-09t52zix 548 23 prognosis prognosis NN cord-007788-09t52zix 548 24 with with IN cord-007788-09t52zix 548 25 95 95 CD cord-007788-09t52zix 548 26 % % NN cord-007788-09t52zix 548 27 mortality mortality NN cord-007788-09t52zix 548 28 . . . cord-007788-09t52zix 549 1 For for IN cord-007788-09t52zix 549 2 IPS IPS NNP cord-007788-09t52zix 549 3 the the DT cord-007788-09t52zix 549 4 following follow VBG cord-007788-09t52zix 549 5 risk risk NN cord-007788-09t52zix 549 6 factors factor NNS cord-007788-09t52zix 549 7 have have VBP cord-007788-09t52zix 549 8 been be VBN cord-007788-09t52zix 549 9 identified identify VBN cord-007788-09t52zix 550 1 ( ( -LRB- cord-007788-09t52zix 550 2 Diab Diab NNP cord-007788-09t52zix 550 3 et et NNP cord-007788-09t52zix 550 4 al al NNP cord-007788-09t52zix 550 5 . . . cord-007788-09t52zix 551 1 2016 2016 CD cord-007788-09t52zix 552 1 ): ): NNP cord-007788-09t52zix 553 1 • • NNP cord-007788-09t52zix 554 1 Older old JJR cord-007788-09t52zix 554 2 age age NN cord-007788-09t52zix 555 1 • • NNP cord-007788-09t52zix 555 2 Low low JJ cord-007788-09t52zix 555 3 performance performance NN cord-007788-09t52zix 555 4 status status NN cord-007788-09t52zix 555 5 ( ( -LRB- cord-007788-09t52zix 555 6 Karnofsky Karnofsky NNP cord-007788-09t52zix 555 7 score score NN cord-007788-09t52zix 555 8 ) ) -RRB- cord-007788-09t52zix 556 1 • • NFP cord-007788-09t52zix 556 2 High high JJ cord-007788-09t52zix 556 3 - - HYPH cord-007788-09t52zix 556 4 intensity intensity NN cord-007788-09t52zix 556 5 conditioning conditioning NN cord-007788-09t52zix 556 6 regimen regimen NN cord-007788-09t52zix 557 1 • • NNP cord-007788-09t52zix 558 1 Total total JJ cord-007788-09t52zix 558 2 body body NN cord-007788-09t52zix 558 3 irradiation irradiation NN cord-007788-09t52zix 558 4 ( ( -LRB- cord-007788-09t52zix 558 5 TBI TBI NNP cord-007788-09t52zix 558 6 ) ) -RRB- cord-007788-09t52zix 559 1 • • NNP cord-007788-09t52zix 560 1 Allo Allo NNP cord-007788-09t52zix 560 2 - - HYPH cord-007788-09t52zix 560 3 HSCT HSCT NNP cord-007788-09t52zix 561 1 • • NNP cord-007788-09t52zix 562 1 Acute acute JJ cord-007788-09t52zix 562 2 graft graft NN cord-007788-09t52zix 562 3 versus versus IN cord-007788-09t52zix 562 4 host host NN cord-007788-09t52zix 562 5 disease disease NN cord-007788-09t52zix 562 6 ( ( -LRB- cord-007788-09t52zix 562 7 aGvHD agvhd NN cord-007788-09t52zix 562 8 ) ) -RRB- cord-007788-09t52zix 563 1 • • NNP cord-007788-09t52zix 564 1 Malignant malignant JJ cord-007788-09t52zix 564 2 disease disease NN cord-007788-09t52zix 564 3 Pre pre JJ cord-007788-09t52zix 564 4 - - JJ cord-007788-09t52zix 564 5 transplant transplant JJ cord-007788-09t52zix 564 6 pulmonary pulmonary JJ cord-007788-09t52zix 564 7 function function NN cord-007788-09t52zix 564 8 abnormalities abnormality NNS cord-007788-09t52zix 564 9 have have VBP cord-007788-09t52zix 564 10 also also RB cord-007788-09t52zix 564 11 been be VBN cord-007788-09t52zix 564 12 associated associate VBN cord-007788-09t52zix 564 13 with with IN cord-007788-09t52zix 564 14 early early JJ cord-007788-09t52zix 564 15 respiratory respiratory JJ cord-007788-09t52zix 564 16 failure failure NN cord-007788-09t52zix 564 17 and and CC cord-007788-09t52zix 564 18 mortality mortality NN cord-007788-09t52zix 564 19 ( ( -LRB- cord-007788-09t52zix 564 20 Chien Chien NNP cord-007788-09t52zix 564 21 et et FW cord-007788-09t52zix 564 22 al al NNP cord-007788-09t52zix 564 23 . . NNP cord-007788-09t52zix 564 24 2005 2005 CD cord-007788-09t52zix 564 25 ) ) -RRB- cord-007788-09t52zix 564 26 . . . cord-007788-09t52zix 565 1 Educate educate VB cord-007788-09t52zix 565 2 the the DT cord-007788-09t52zix 565 3 patient patient NN cord-007788-09t52zix 565 4 about about IN cord-007788-09t52zix 565 5 signs sign NNS cord-007788-09t52zix 565 6 and and CC cord-007788-09t52zix 565 7 symptoms symptom NNS cord-007788-09t52zix 565 8 of of IN cord-007788-09t52zix 565 9 ES es NN cord-007788-09t52zix 565 10 and and CC cord-007788-09t52zix 565 11 explain explain VB cord-007788-09t52zix 565 12 why why WRB cord-007788-09t52zix 565 13 it -PRON- PRP cord-007788-09t52zix 565 14 is be VBZ cord-007788-09t52zix 565 15 important important JJ cord-007788-09t52zix 565 16 to to TO cord-007788-09t52zix 565 17 report report VB cord-007788-09t52zix 565 18 any any DT cord-007788-09t52zix 565 19 symptoms symptom NNS cord-007788-09t52zix 565 20 without without IN cord-007788-09t52zix 565 21 delay delay NN cord-007788-09t52zix 565 22 . . . cord-007788-09t52zix 566 1 Explain explain VB cord-007788-09t52zix 566 2 actions action NNS cord-007788-09t52zix 566 3 taken take VBN cord-007788-09t52zix 566 4 in in IN cord-007788-09t52zix 566 5 diagnosis diagnosis NN cord-007788-09t52zix 566 6 and and CC cord-007788-09t52zix 566 7 management management NN cord-007788-09t52zix 566 8 of of IN cord-007788-09t52zix 566 9 ES ES NNP cord-007788-09t52zix 566 10 and and CC cord-007788-09t52zix 566 11 provide provide VB cord-007788-09t52zix 566 12 emotional emotional JJ cord-007788-09t52zix 566 13 support support NN cord-007788-09t52zix 566 14 to to IN cord-007788-09t52zix 566 15 both both DT cord-007788-09t52zix 566 16 patient patient NN cord-007788-09t52zix 566 17 and and CC cord-007788-09t52zix 566 18 family family NN cord-007788-09t52zix 566 19 Thoele Thoele NNP cord-007788-09t52zix 567 1 ( ( -LRB- cord-007788-09t52zix 567 2 2014 2014 CD cord-007788-09t52zix 567 3 ) ) -RRB- cord-007788-09t52zix 567 4 _SP cord-007788-09t52zix 568 1 The the DT cord-007788-09t52zix 568 2 most most RBS cord-007788-09t52zix 568 3 common common JJ cord-007788-09t52zix 568 4 signs sign NNS cord-007788-09t52zix 568 5 and and CC cord-007788-09t52zix 568 6 symptoms symptom NNS cord-007788-09t52zix 568 7 are be VBP cord-007788-09t52zix 568 8 fever fever NN cord-007788-09t52zix 568 9 , , , cord-007788-09t52zix 568 10 non non JJ cord-007788-09t52zix 568 11 - - JJ cord-007788-09t52zix 568 12 productive productive JJ cord-007788-09t52zix 568 13 cough cough NN cord-007788-09t52zix 568 14 , , , cord-007788-09t52zix 568 15 rales rale NNS cord-007788-09t52zix 568 16 , , , cord-007788-09t52zix 568 17 dyspnoea dyspnoea NNS cord-007788-09t52zix 568 18 , , , cord-007788-09t52zix 568 19 tachypnoea tachypnoea NNS cord-007788-09t52zix 568 20 and and CC cord-007788-09t52zix 568 21 low low JJ cord-007788-09t52zix 568 22 saturation saturation NN cord-007788-09t52zix 568 23 with with IN cord-007788-09t52zix 568 24 an an DT cord-007788-09t52zix 568 25 increasing increase VBG cord-007788-09t52zix 568 26 need need NN cord-007788-09t52zix 568 27 for for IN cord-007788-09t52zix 568 28 oxygen oxygen NN cord-007788-09t52zix 568 29 support support NN cord-007788-09t52zix 568 30 . . . cord-007788-09t52zix 569 1 The the DT cord-007788-09t52zix 569 2 diagnosis diagnosis NN cord-007788-09t52zix 569 3 will will MD cord-007788-09t52zix 569 4 be be VB cord-007788-09t52zix 569 5 based base VBN cord-007788-09t52zix 569 6 on on IN cord-007788-09t52zix 569 7 alveolar alveolar JJ cord-007788-09t52zix 569 8 injury injury NN cord-007788-09t52zix 569 9 confirmed confirm VBD cord-007788-09t52zix 569 10 clinically clinically RB cord-007788-09t52zix 569 11 , , , cord-007788-09t52zix 569 12 radiologically radiologically RB cord-007788-09t52zix 569 13 and/or and/or CC cord-007788-09t52zix 569 14 functionally functionally RB cord-007788-09t52zix 569 15 . . . cord-007788-09t52zix 570 1 X x NN cord-007788-09t52zix 570 2 - - NN cord-007788-09t52zix 570 3 ray ray NN cord-007788-09t52zix 570 4 will will MD cord-007788-09t52zix 570 5 reveal reveal VB cord-007788-09t52zix 570 6 diffuse diffuse JJ cord-007788-09t52zix 570 7 pulmonary pulmonary JJ cord-007788-09t52zix 570 8 infiltrates infiltrate NNS cord-007788-09t52zix 570 9 . . . cord-007788-09t52zix 571 1 Infection infection NN cord-007788-09t52zix 571 2 must must MD cord-007788-09t52zix 571 3 have have VB cord-007788-09t52zix 571 4 been be VBN cord-007788-09t52zix 571 5 ruled rule VBN cord-007788-09t52zix 571 6 out out RP cord-007788-09t52zix 571 7 by by IN cord-007788-09t52zix 571 8 negative negative JJ cord-007788-09t52zix 571 9 cultures culture NNS cord-007788-09t52zix 571 10 and and CC cord-007788-09t52zix 571 11 tests test NNS cord-007788-09t52zix 571 12 in in IN cord-007788-09t52zix 571 13 bronchoalveolar bronchoalveolar NNP cord-007788-09t52zix 571 14 lavage lavage NNP cord-007788-09t52zix 571 15 ( ( -LRB- cord-007788-09t52zix 571 16 BAL BAL NNP cord-007788-09t52zix 571 17 ) ) -RRB- cord-007788-09t52zix 571 18 or or CC cord-007788-09t52zix 571 19 lung lung NN cord-007788-09t52zix 571 20 biopsies biopsy NNS cord-007788-09t52zix 571 21 ( ( -LRB- cord-007788-09t52zix 571 22 Zhu zhu FW cord-007788-09t52zix 571 23 et et FW cord-007788-09t52zix 571 24 al al NNP cord-007788-09t52zix 571 25 . . NNP cord-007788-09t52zix 571 26 2008 2008 CD cord-007788-09t52zix 571 27 ) ) -RRB- cord-007788-09t52zix 571 28 , , , cord-007788-09t52zix 571 29 and and CC cord-007788-09t52zix 571 30 there there EX cord-007788-09t52zix 571 31 should should MD cord-007788-09t52zix 571 32 be be VB cord-007788-09t52zix 571 33 no no DT cord-007788-09t52zix 571 34 evidence evidence NN cord-007788-09t52zix 571 35 of of IN cord-007788-09t52zix 571 36 cardiac cardiac JJ cord-007788-09t52zix 571 37 dysfunction dysfunction NN cord-007788-09t52zix 571 38 , , , cord-007788-09t52zix 571 39 acute acute JJ cord-007788-09t52zix 571 40 renal renal JJ cord-007788-09t52zix 571 41 failure failure NN cord-007788-09t52zix 571 42 or or CC cord-007788-09t52zix 571 43 treatment treatment NN cord-007788-09t52zix 571 44 - - HYPH cord-007788-09t52zix 571 45 related relate VBN cord-007788-09t52zix 571 46 fluid fluid JJ cord-007788-09t52zix 571 47 overload overload NN cord-007788-09t52zix 571 48 . . . cord-007788-09t52zix 572 1 It -PRON- PRP cord-007788-09t52zix 572 2 is be VBZ cord-007788-09t52zix 572 3 however however RB cord-007788-09t52zix 572 4 considered consider VBN cord-007788-09t52zix 572 5 possible possible JJ cord-007788-09t52zix 572 6 that that IN cord-007788-09t52zix 572 7 some some DT cord-007788-09t52zix 572 8 cases case NNS cord-007788-09t52zix 572 9 of of IN cord-007788-09t52zix 572 10 IPS IPS NNP cord-007788-09t52zix 572 11 may may MD cord-007788-09t52zix 572 12 be be VB cord-007788-09t52zix 572 13 caused cause VBN cord-007788-09t52zix 572 14 by by IN cord-007788-09t52zix 572 15 an an DT cord-007788-09t52zix 572 16 unidentified unidentified JJ cord-007788-09t52zix 572 17 underlying underlie VBG cord-007788-09t52zix 572 18 infection infection NN cord-007788-09t52zix 572 19 since since IN cord-007788-09t52zix 572 20 infections infection NNS cord-007788-09t52zix 572 21 may may MD cord-007788-09t52zix 572 22 lack lack VB cord-007788-09t52zix 572 23 typical typical JJ cord-007788-09t52zix 572 24 signs sign NNS cord-007788-09t52zix 572 25 and and CC cord-007788-09t52zix 572 26 symptoms symptom NNS cord-007788-09t52zix 572 27 in in IN cord-007788-09t52zix 572 28 the the DT cord-007788-09t52zix 572 29 neutropenic neutropenic JJ cord-007788-09t52zix 572 30 patient patient NN cord-007788-09t52zix 572 31 . . . cord-007788-09t52zix 573 1 The the DT cord-007788-09t52zix 573 2 IPS IPS NNP cord-007788-09t52zix 573 3 diagnosis diagnosis NN cord-007788-09t52zix 573 4 can can MD cord-007788-09t52zix 573 5 thus thus RB cord-007788-09t52zix 573 6 be be VB cord-007788-09t52zix 573 7 supported support VBN cord-007788-09t52zix 573 8 by by IN cord-007788-09t52zix 573 9 lack lack NN cord-007788-09t52zix 573 10 of of IN cord-007788-09t52zix 573 11 improvement improvement NN cord-007788-09t52zix 573 12 despite despite IN cord-007788-09t52zix 573 13 broad broad JJ cord-007788-09t52zix 573 14 - - HYPH cord-007788-09t52zix 573 15 spectrum spectrum NN cord-007788-09t52zix 573 16 antibiotics antibiotic NNS cord-007788-09t52zix 573 17 and and CC cord-007788-09t52zix 573 18 other other JJ cord-007788-09t52zix 573 19 antimicrobial antimicrobial JJ cord-007788-09t52zix 573 20 drugs drug NNS cord-007788-09t52zix 573 21 . . . cord-007788-09t52zix 574 1 The the DT cord-007788-09t52zix 574 2 typical typical JJ cord-007788-09t52zix 574 3 onset onset NN cord-007788-09t52zix 574 4 will will MD cord-007788-09t52zix 574 5 be be VB cord-007788-09t52zix 574 6 around around IN cord-007788-09t52zix 574 7 day day NN cord-007788-09t52zix 574 8 +20 +20 CD cord-007788-09t52zix 574 9 , , , cord-007788-09t52zix 574 10 but but CC cord-007788-09t52zix 574 11 IPS IPS NNP cord-007788-09t52zix 574 12 may may MD cord-007788-09t52zix 574 13 also also RB cord-007788-09t52zix 574 14 present present VB cord-007788-09t52zix 574 15 later later RB cord-007788-09t52zix 574 16 after after IN cord-007788-09t52zix 574 17 HSCT HSCT NNP cord-007788-09t52zix 574 18 , , , cord-007788-09t52zix 574 19 why why WRB cord-007788-09t52zix 574 20 it -PRON- PRP cord-007788-09t52zix 574 21 is be VBZ cord-007788-09t52zix 574 22 important important JJ cord-007788-09t52zix 574 23 to to TO cord-007788-09t52zix 574 24 be be VB cord-007788-09t52zix 574 25 alert alert JJ cord-007788-09t52zix 574 26 for for IN cord-007788-09t52zix 574 27 this this DT cord-007788-09t52zix 574 28 complication complication NN cord-007788-09t52zix 574 29 also also RB cord-007788-09t52zix 574 30 after after IN cord-007788-09t52zix 574 31 discharge discharge NN cord-007788-09t52zix 574 32 from from IN cord-007788-09t52zix 574 33 the the DT cord-007788-09t52zix 574 34 hospital hospital NN cord-007788-09t52zix 574 35 , , , cord-007788-09t52zix 574 36 in in IN cord-007788-09t52zix 574 37 the the DT cord-007788-09t52zix 574 38 outpatient outpatient NN cord-007788-09t52zix 574 39 setting setting NN cord-007788-09t52zix 574 40 . . . cord-007788-09t52zix 575 1 There there EX cord-007788-09t52zix 575 2 are be VBP cord-007788-09t52zix 575 3 no no DT cord-007788-09t52zix 575 4 standard standard JJ cord-007788-09t52zix 575 5 guidelines guideline NNS cord-007788-09t52zix 575 6 for for IN cord-007788-09t52zix 575 7 diagnosis diagnosis NN cord-007788-09t52zix 575 8 and and CC cord-007788-09t52zix 575 9 evaluation evaluation NN cord-007788-09t52zix 575 10 of of IN cord-007788-09t52zix 575 11 PC pc NN cord-007788-09t52zix 575 12 after after IN cord-007788-09t52zix 575 13 HSCT HSCT NNP cord-007788-09t52zix 575 14 , , , cord-007788-09t52zix 575 15 but but CC cord-007788-09t52zix 575 16 the the DT cord-007788-09t52zix 575 17 course course NN cord-007788-09t52zix 575 18 of of IN cord-007788-09t52zix 575 19 illness illness NN cord-007788-09t52zix 575 20 should should MD cord-007788-09t52zix 575 21 be be VB cord-007788-09t52zix 575 22 considered consider VBN cord-007788-09t52zix 575 23 when when WRB cord-007788-09t52zix 575 24 differential differential JJ cord-007788-09t52zix 575 25 diagnoses diagnosis NNS cord-007788-09t52zix 575 26 are be VBP cord-007788-09t52zix 575 27 to to TO cord-007788-09t52zix 575 28 be be VB cord-007788-09t52zix 575 29 excluded exclude VBN cord-007788-09t52zix 575 30 . . . cord-007788-09t52zix 576 1 When when WRB cord-007788-09t52zix 576 2 symptoms symptom NNS cord-007788-09t52zix 576 3 occur occur VBP cord-007788-09t52zix 576 4 , , , cord-007788-09t52zix 576 5 IPS IPS NNP cord-007788-09t52zix 576 6 may may MD cord-007788-09t52zix 576 7 rapidly rapidly RB cord-007788-09t52zix 576 8 progress progress VB cord-007788-09t52zix 576 9 to to IN cord-007788-09t52zix 576 10 pulmonary pulmonary JJ cord-007788-09t52zix 576 11 dysfunction dysfunction NN cord-007788-09t52zix 576 12 requiring require VBG cord-007788-09t52zix 576 13 mechanical mechanical JJ cord-007788-09t52zix 576 14 ventilation ventilation NN cord-007788-09t52zix 576 15 . . . cord-007788-09t52zix 577 1 For for IN cord-007788-09t52zix 577 2 patients patient NNS cord-007788-09t52zix 577 3 at at IN cord-007788-09t52zix 577 4 risk risk NN cord-007788-09t52zix 577 5 for for IN cord-007788-09t52zix 577 6 IPS IPS NNP cord-007788-09t52zix 577 7 , , , cord-007788-09t52zix 577 8 careful careful JJ cord-007788-09t52zix 577 9 consideration consideration NN cord-007788-09t52zix 577 10 of of IN cord-007788-09t52zix 577 11 treatment treatment NN cord-007788-09t52zix 577 12 options option NNS cord-007788-09t52zix 577 13 pre pre VBP cord-007788-09t52zix 577 14 - - NN cord-007788-09t52zix 577 15 and and CC cord-007788-09t52zix 577 16 posttransplant posttransplant NN cord-007788-09t52zix 577 17 such such JJ cord-007788-09t52zix 577 18 as as IN cord-007788-09t52zix 577 19 avoiding avoid VBG cord-007788-09t52zix 577 20 conditioning conditioning NN cord-007788-09t52zix 577 21 with with IN cord-007788-09t52zix 577 22 TBI TBI NNP cord-007788-09t52zix 577 23 or or CC cord-007788-09t52zix 577 24 highintensity highintensity NN cord-007788-09t52zix 577 25 regimens regimen NNS cord-007788-09t52zix 577 26 and and CC cord-007788-09t52zix 577 27 choice choice NN cord-007788-09t52zix 577 28 of of IN cord-007788-09t52zix 577 29 GvHD GvHD NNP cord-007788-09t52zix 577 30 prophylaxis prophylaxis NN cord-007788-09t52zix 577 31 may may MD cord-007788-09t52zix 577 32 be be VB cord-007788-09t52zix 577 33 beneficial beneficial JJ cord-007788-09t52zix 577 34 . . . cord-007788-09t52zix 578 1 Monitoring monitoring NN cord-007788-09t52zix 578 2 of of IN cord-007788-09t52zix 578 3 pulmonary pulmonary JJ cord-007788-09t52zix 578 4 function function NN cord-007788-09t52zix 578 5 and and CC cord-007788-09t52zix 578 6 symptoms symptom NNS cord-007788-09t52zix 578 7 after after IN cord-007788-09t52zix 578 8 transplantation transplantation NN cord-007788-09t52zix 578 9 will will MD cord-007788-09t52zix 578 10 enable enable VB cord-007788-09t52zix 578 11 prompt prompt JJ cord-007788-09t52zix 578 12 intervention intervention NN cord-007788-09t52zix 578 13 . . . cord-007788-09t52zix 579 1 In in IN cord-007788-09t52zix 579 2 patients patient NNS cord-007788-09t52zix 579 3 with with IN cord-007788-09t52zix 579 4 decreased decrease VBN cord-007788-09t52zix 579 5 lung lung NN cord-007788-09t52zix 579 6 function function NN cord-007788-09t52zix 579 7 prior prior RB cord-007788-09t52zix 579 8 to to IN cord-007788-09t52zix 579 9 HSCT HSCT NNP cord-007788-09t52zix 579 10 and and CC cord-007788-09t52zix 579 11 suspected suspect VBN cord-007788-09t52zix 579 12 lung lung NN cord-007788-09t52zix 579 13 injury injury NN cord-007788-09t52zix 579 14 in in IN cord-007788-09t52zix 579 15 the the DT cord-007788-09t52zix 579 16 posttransplant posttransplant NN cord-007788-09t52zix 579 17 setting setting NN cord-007788-09t52zix 579 18 , , , cord-007788-09t52zix 579 19 close close JJ cord-007788-09t52zix 579 20 collaboration collaboration NN cord-007788-09t52zix 579 21 with with IN cord-007788-09t52zix 579 22 pulmonary pulmonary JJ cord-007788-09t52zix 579 23 specialist specialist NN cord-007788-09t52zix 579 24 or or CC cord-007788-09t52zix 579 25 the the DT cord-007788-09t52zix 579 26 intensive intensive JJ cord-007788-09t52zix 579 27 care care NN cord-007788-09t52zix 579 28 team team NN cord-007788-09t52zix 579 29 may may MD cord-007788-09t52zix 579 30 prevent prevent VB cord-007788-09t52zix 579 31 progression progression NN cord-007788-09t52zix 579 32 of of IN cord-007788-09t52zix 579 33 pulmonary pulmonary JJ cord-007788-09t52zix 579 34 dysfunction dysfunction NN cord-007788-09t52zix 580 1 ( ( -LRB- cord-007788-09t52zix 580 2 Elbahlawan Elbahlawan NNP cord-007788-09t52zix 580 3 et et NNP cord-007788-09t52zix 580 4 al al NNP cord-007788-09t52zix 580 5 . . . cord-007788-09t52zix 580 6 2016 2016 CD cord-007788-09t52zix 580 7 ) ) -RRB- cord-007788-09t52zix 580 8 . . . cord-007788-09t52zix 581 1 Beyond beyond IN cord-007788-09t52zix 581 2 supportive supportive JJ cord-007788-09t52zix 581 3 care care NN cord-007788-09t52zix 581 4 , , , cord-007788-09t52zix 581 5 there there EX cord-007788-09t52zix 581 6 is be VBZ cord-007788-09t52zix 581 7 no no DT cord-007788-09t52zix 581 8 proven prove VBN cord-007788-09t52zix 581 9 treatment treatment NN cord-007788-09t52zix 581 10 for for IN cord-007788-09t52zix 581 11 IPS IPS NNP cord-007788-09t52zix 581 12 . . . cord-007788-09t52zix 582 1 In in IN cord-007788-09t52zix 582 2 auto auto NN cord-007788-09t52zix 582 3 - - HYPH cord-007788-09t52zix 582 4 HSCT HSCT NNP cord-007788-09t52zix 582 5 patients patient NNS cord-007788-09t52zix 582 6 , , , cord-007788-09t52zix 582 7 corticosteroids corticosteroid NNS cord-007788-09t52zix 582 8 can can MD cord-007788-09t52zix 582 9 be be VB cord-007788-09t52zix 582 10 effective effective JJ cord-007788-09t52zix 582 11 , , , cord-007788-09t52zix 582 12 but but CC cord-007788-09t52zix 582 13 this this DT cord-007788-09t52zix 582 14 is be VBZ cord-007788-09t52zix 582 15 usually usually RB cord-007788-09t52zix 582 16 not not RB cord-007788-09t52zix 582 17 the the DT cord-007788-09t52zix 582 18 case case NN cord-007788-09t52zix 582 19 for for IN cord-007788-09t52zix 582 20 allo allo NN cord-007788-09t52zix 582 21 - - HYPH cord-007788-09t52zix 582 22 transplanted transplant VBN cord-007788-09t52zix 582 23 patients patient NNS cord-007788-09t52zix 582 24 , , , cord-007788-09t52zix 582 25 irrespective irrespective RB cord-007788-09t52zix 582 26 of of IN cord-007788-09t52zix 582 27 steroid steroid NN cord-007788-09t52zix 582 28 dose dose NN cord-007788-09t52zix 582 29 . . . cord-007788-09t52zix 583 1 Studies study NNS cord-007788-09t52zix 583 2 with with IN cord-007788-09t52zix 583 3 etanercept etanercept NNP cord-007788-09t52zix 583 4 , , , cord-007788-09t52zix 583 5 a a DT cord-007788-09t52zix 583 6 TNF TNF NNP cord-007788-09t52zix 583 7 - - HYPH cord-007788-09t52zix 583 8 αbinding αbinde VBG cord-007788-09t52zix 583 9 protein protein NN cord-007788-09t52zix 583 10 , , , cord-007788-09t52zix 583 11 given give VBN cord-007788-09t52zix 583 12 in in IN cord-007788-09t52zix 583 13 combination combination NN cord-007788-09t52zix 583 14 with with IN cord-007788-09t52zix 583 15 corticosteroids corticosteroid NNS cord-007788-09t52zix 583 16 have have VBP cord-007788-09t52zix 583 17 reported report VBN cord-007788-09t52zix 583 18 improved improve VBN cord-007788-09t52zix 583 19 pulmonary pulmonary JJ cord-007788-09t52zix 583 20 function function NN cord-007788-09t52zix 583 21 in in IN cord-007788-09t52zix 583 22 patients patient NNS cord-007788-09t52zix 583 23 with with IN cord-007788-09t52zix 583 24 IPS IPS NNP cord-007788-09t52zix 583 25 following follow VBG cord-007788-09t52zix 583 26 allogeneic allogeneic IN cord-007788-09t52zix 583 27 HSCT HSCT NNP cord-007788-09t52zix 583 28 and and CC cord-007788-09t52zix 583 29 may may MD cord-007788-09t52zix 583 30 be be VB cord-007788-09t52zix 583 31 considered consider VBN cord-007788-09t52zix 583 32 ( ( -LRB- cord-007788-09t52zix 583 33 Carreras Carreras NNP cord-007788-09t52zix 583 34 2012 2012 CD cord-007788-09t52zix 583 35 ) ) -RRB- cord-007788-09t52zix 584 1 although although IN cord-007788-09t52zix 584 2 a a DT cord-007788-09t52zix 584 3 small small JJ cord-007788-09t52zix 584 4 but but CC cord-007788-09t52zix 584 5 later later JJ cord-007788-09t52zix 584 6 study study NN cord-007788-09t52zix 584 7 ( ( -LRB- cord-007788-09t52zix 584 8 Yanik Yanik NNP cord-007788-09t52zix 584 9 et et FW cord-007788-09t52zix 584 10 al al NNP cord-007788-09t52zix 584 11 . . NNP cord-007788-09t52zix 584 12 2014 2014 CD cord-007788-09t52zix 584 13 ) ) -RRB- cord-007788-09t52zix 584 14 could could MD cord-007788-09t52zix 584 15 not not RB cord-007788-09t52zix 584 16 confirm confirm VB cord-007788-09t52zix 584 17 the the DT cord-007788-09t52zix 584 18 benefit benefit NN cord-007788-09t52zix 584 19 of of IN cord-007788-09t52zix 584 20 this this DT cord-007788-09t52zix 584 21 treatment treatment NN cord-007788-09t52zix 584 22 . . . cord-007788-09t52zix 585 1 The the DT cord-007788-09t52zix 585 2 close close JJ cord-007788-09t52zix 585 3 monitoring monitoring NN cord-007788-09t52zix 585 4 and and CC cord-007788-09t52zix 585 5 daily daily JJ cord-007788-09t52zix 585 6 nursing nursing NN cord-007788-09t52zix 585 7 assessments assessment NNS cord-007788-09t52zix 585 8 that that WDT cord-007788-09t52zix 585 9 apply apply VBP cord-007788-09t52zix 585 10 for for IN cord-007788-09t52zix 585 11 all all DT cord-007788-09t52zix 585 12 HSCT HSCT NNP cord-007788-09t52zix 585 13 patients patient NNS cord-007788-09t52zix 585 14 should should MD cord-007788-09t52zix 585 15 be be VB cord-007788-09t52zix 585 16 employed employ VBN cord-007788-09t52zix 585 17 . . . cord-007788-09t52zix 586 1 Depending depend VBG cord-007788-09t52zix 586 2 on on IN cord-007788-09t52zix 586 3 risk risk NN cord-007788-09t52zix 586 4 factors factor NNS cord-007788-09t52zix 586 5 , , , cord-007788-09t52zix 586 6 extra extra JJ cord-007788-09t52zix 586 7 attention attention NN cord-007788-09t52zix 586 8 may may MD cord-007788-09t52zix 586 9 be be VB cord-007788-09t52zix 586 10 needed need VBN cord-007788-09t52zix 586 11 to to TO cord-007788-09t52zix 586 12 early early JJ cord-007788-09t52zix 586 13 and and CC cord-007788-09t52zix 586 14 subtle subtle JJ cord-007788-09t52zix 586 15 symptoms symptom NNS cord-007788-09t52zix 586 16 of of IN cord-007788-09t52zix 586 17 pulmonary pulmonary JJ cord-007788-09t52zix 586 18 dysfunction dysfunction NN cord-007788-09t52zix 586 19 , , , cord-007788-09t52zix 586 20 such such JJ cord-007788-09t52zix 586 21 as as IN cord-007788-09t52zix 586 22 decrease decrease NN cord-007788-09t52zix 586 23 in in IN cord-007788-09t52zix 586 24 saturation saturation NN cord-007788-09t52zix 586 25 , , , cord-007788-09t52zix 586 26 shortness shortness NN cord-007788-09t52zix 586 27 of of IN cord-007788-09t52zix 586 28 breath breath NN cord-007788-09t52zix 586 29 and and CC cord-007788-09t52zix 586 30 cough cough NN cord-007788-09t52zix 586 31 . . . cord-007788-09t52zix 587 1 Monitoring monitoring NN cord-007788-09t52zix 587 2 of of IN cord-007788-09t52zix 587 3 daily daily JJ cord-007788-09t52zix 587 4 weight weight NN cord-007788-09t52zix 587 5 and and CC cord-007788-09t52zix 587 6 fluid fluid JJ cord-007788-09t52zix 587 7 balance balance NN cord-007788-09t52zix 587 8 , , , cord-007788-09t52zix 587 9 with with IN cord-007788-09t52zix 587 10 administration administration NN cord-007788-09t52zix 587 11 of of IN cord-007788-09t52zix 587 12 diuretics diuretic NNS cord-007788-09t52zix 587 13 if if IN cord-007788-09t52zix 587 14 necessary necessary JJ cord-007788-09t52zix 587 15 , , , cord-007788-09t52zix 587 16 will will MD cord-007788-09t52zix 587 17 prevent prevent VB cord-007788-09t52zix 587 18 and and CC cord-007788-09t52zix 587 19 rule rule VB cord-007788-09t52zix 587 20 out out RP cord-007788-09t52zix 587 21 fluid fluid JJ cord-007788-09t52zix 587 22 overload overload NN cord-007788-09t52zix 587 23 . . . cord-007788-09t52zix 588 1 Several several JJ cord-007788-09t52zix 588 2 different different JJ cord-007788-09t52zix 588 3 tests test NNS cord-007788-09t52zix 588 4 and and CC cord-007788-09t52zix 588 5 examinations examination NNS cord-007788-09t52zix 588 6 may may MD cord-007788-09t52zix 588 7 be be VB cord-007788-09t52zix 588 8 performed perform VBN cord-007788-09t52zix 588 9 to to TO cord-007788-09t52zix 588 10 establish establish VB cord-007788-09t52zix 588 11 or or CC cord-007788-09t52zix 588 12 rule rule VB cord-007788-09t52zix 588 13 out out RP cord-007788-09t52zix 588 14 the the DT cord-007788-09t52zix 588 15 diagnosis diagnosis NN cord-007788-09t52zix 588 16 of of IN cord-007788-09t52zix 588 17 IPS IPS NNP cord-007788-09t52zix 588 18 . . . cord-007788-09t52zix 589 1 Sputum sputum NN cord-007788-09t52zix 589 2 cultures culture NNS cord-007788-09t52zix 589 3 and and CC cord-007788-09t52zix 589 4 laboratory laboratory NN cord-007788-09t52zix 589 5 tests test NNS cord-007788-09t52zix 589 6 , , , cord-007788-09t52zix 589 7 such such JJ cord-007788-09t52zix 589 8 as as IN cord-007788-09t52zix 589 9 polymerase polymerase NN cord-007788-09t52zix 589 10 chain chain NN cord-007788-09t52zix 589 11 reaction reaction NN cord-007788-09t52zix 589 12 ( ( -LRB- cord-007788-09t52zix 589 13 PCR PCR NNP cord-007788-09t52zix 589 14 ) ) -RRB- cord-007788-09t52zix 589 15 for for IN cord-007788-09t52zix 589 16 mycoplasma mycoplasma NN cord-007788-09t52zix 589 17 , , , cord-007788-09t52zix 589 18 and and CC cord-007788-09t52zix 589 19 serum serum NN cord-007788-09t52zix 589 20 galactomannan galactomannan NNP cord-007788-09t52zix 589 21 for for IN cord-007788-09t52zix 589 22 Aspergillus Aspergillus NNP cord-007788-09t52zix 589 23 may may MD cord-007788-09t52zix 589 24 need need VB cord-007788-09t52zix 589 25 to to TO cord-007788-09t52zix 589 26 be be VB cord-007788-09t52zix 589 27 obtained obtain VBN cord-007788-09t52zix 589 28 , , , cord-007788-09t52zix 589 29 and and CC cord-007788-09t52zix 589 30 chest chest NN cord-007788-09t52zix 589 31 X x NN cord-007788-09t52zix 589 32 - - NN cord-007788-09t52zix 589 33 ray ray NN cord-007788-09t52zix 589 34 or or CC cord-007788-09t52zix 589 35 computed compute VBN cord-007788-09t52zix 589 36 tomography tomography NN cord-007788-09t52zix 589 37 ( ( -LRB- cord-007788-09t52zix 589 38 CT CT NNP cord-007788-09t52zix 589 39 ) ) -RRB- cord-007788-09t52zix 589 40 scan scan NN cord-007788-09t52zix 589 41 performed perform VBN cord-007788-09t52zix 589 42 to to TO cord-007788-09t52zix 589 43 rule rule VB cord-007788-09t52zix 589 44 out out RP cord-007788-09t52zix 589 45 infection infection NN cord-007788-09t52zix 589 46 . . . cord-007788-09t52zix 590 1 In in IN cord-007788-09t52zix 590 2 case case NN cord-007788-09t52zix 590 3 a a DT cord-007788-09t52zix 590 4 BAL bal NN cord-007788-09t52zix 590 5 , , , cord-007788-09t52zix 590 6 with with IN cord-007788-09t52zix 590 7 or or CC cord-007788-09t52zix 590 8 without without IN cord-007788-09t52zix 590 9 transbronchial transbronchial NNP cord-007788-09t52zix 590 10 biopsy biopsy NN cord-007788-09t52zix 590 11 , , , cord-007788-09t52zix 590 12 will will MD cord-007788-09t52zix 590 13 be be VB cord-007788-09t52zix 590 14 performed perform VBN cord-007788-09t52zix 590 15 , , , cord-007788-09t52zix 590 16 information information NN cord-007788-09t52zix 590 17 to to IN cord-007788-09t52zix 590 18 the the DT cord-007788-09t52zix 590 19 patient patient NN cord-007788-09t52zix 590 20 and and CC cord-007788-09t52zix 590 21 preparation preparation NN cord-007788-09t52zix 590 22 prior prior RB cord-007788-09t52zix 590 23 to to IN cord-007788-09t52zix 590 24 the the DT cord-007788-09t52zix 590 25 procedure procedure NN cord-007788-09t52zix 590 26 as as RB cord-007788-09t52zix 590 27 well well RB cord-007788-09t52zix 590 28 as as IN cord-007788-09t52zix 590 29 support support NN cord-007788-09t52zix 590 30 both both CC cord-007788-09t52zix 590 31 before before IN cord-007788-09t52zix 590 32 and and CC cord-007788-09t52zix 590 33 after after IN cord-007788-09t52zix 590 34 and and CC cord-007788-09t52zix 590 35 post post NN cord-007788-09t52zix 590 36 procedure procedure NN cord-007788-09t52zix 590 37 monitoring monitoring NN cord-007788-09t52zix 590 38 is be VBZ cord-007788-09t52zix 590 39 important important JJ cord-007788-09t52zix 590 40 . . . cord-007788-09t52zix 591 1 The the DT cord-007788-09t52zix 591 2 BAL bal NN cord-007788-09t52zix 591 3 may may MD cord-007788-09t52zix 591 4 add add VB cord-007788-09t52zix 591 5 substantial substantial JJ cord-007788-09t52zix 591 6 discomfort discomfort NN cord-007788-09t52zix 591 7 , , , cord-007788-09t52zix 591 8 in in IN cord-007788-09t52zix 591 9 particular particular JJ cord-007788-09t52zix 591 10 to to IN cord-007788-09t52zix 591 11 an an DT cord-007788-09t52zix 591 12 already already RB cord-007788-09t52zix 591 13 seriously seriously RB cord-007788-09t52zix 591 14 ill ill JJ cord-007788-09t52zix 591 15 patient patient JJ cord-007788-09t52zix 591 16 . . . cord-007788-09t52zix 592 1 Other other JJ cord-007788-09t52zix 592 2 lung lung NN cord-007788-09t52zix 592 3 function function NN cord-007788-09t52zix 592 4 tests test NNS cord-007788-09t52zix 592 5 may may MD cord-007788-09t52zix 592 6 also also RB cord-007788-09t52zix 592 7 be be VB cord-007788-09t52zix 592 8 repeated repeat VBN cord-007788-09t52zix 592 9 , , , cord-007788-09t52zix 592 10 for for IN cord-007788-09t52zix 592 11 comparison comparison NN cord-007788-09t52zix 592 12 with with IN cord-007788-09t52zix 592 13 pretransplant pretransplant NN cord-007788-09t52zix 592 14 results result NNS cord-007788-09t52zix 592 15 . . . cord-007788-09t52zix 593 1 When when WRB cord-007788-09t52zix 593 2 corticosteroids corticosteroid NNS cord-007788-09t52zix 593 3 are be VBP cord-007788-09t52zix 593 4 administered administer VBN cord-007788-09t52zix 593 5 , , , cord-007788-09t52zix 593 6 the the DT cord-007788-09t52zix 593 7 blood blood NN cord-007788-09t52zix 593 8 glucose glucose NN cord-007788-09t52zix 593 9 levels level NNS cord-007788-09t52zix 593 10 should should MD cord-007788-09t52zix 593 11 be be VB cord-007788-09t52zix 593 12 followed follow VBN cord-007788-09t52zix 593 13 daily daily RB cord-007788-09t52zix 593 14 and and CC cord-007788-09t52zix 593 15 the the DT cord-007788-09t52zix 593 16 patient patient NN cord-007788-09t52zix 593 17 should should MD cord-007788-09t52zix 593 18 be be VB cord-007788-09t52zix 593 19 informed inform VBN cord-007788-09t52zix 593 20 of of IN cord-007788-09t52zix 593 21 and and CC cord-007788-09t52zix 593 22 assessed assess VBN cord-007788-09t52zix 593 23 for for IN cord-007788-09t52zix 593 24 other other JJ cord-007788-09t52zix 593 25 side side NN cord-007788-09t52zix 593 26 effects effect NNS cord-007788-09t52zix 593 27 , , , cord-007788-09t52zix 593 28 e.g. e.g. RB cord-007788-09t52zix 593 29 insomnia insomnia NN cord-007788-09t52zix 593 30 . . . cord-007788-09t52zix 594 1 Oxygen oxygen NN cord-007788-09t52zix 594 2 therapy therapy NN cord-007788-09t52zix 594 3 may may MD cord-007788-09t52zix 594 4 need need VB cord-007788-09t52zix 594 5 to to TO cord-007788-09t52zix 594 6 be be VB cord-007788-09t52zix 594 7 administered administer VBN cord-007788-09t52zix 594 8 and and CC cord-007788-09t52zix 594 9 noninvasive noninvasive JJ cord-007788-09t52zix 594 10 positive positive JJ cord-007788-09t52zix 594 11 pressure pressure NN cord-007788-09t52zix 594 12 ventilation ventilation NN cord-007788-09t52zix 594 13 necessary necessary JJ cord-007788-09t52zix 594 14 . . . cord-007788-09t52zix 595 1 Respiratory respiratory JJ cord-007788-09t52zix 595 2 difficulties difficulty NNS cord-007788-09t52zix 595 3 generate generate VBP cord-007788-09t52zix 595 4 anxiety anxiety NN cord-007788-09t52zix 595 5 , , , cord-007788-09t52zix 595 6 and and CC cord-007788-09t52zix 595 7 the the DT cord-007788-09t52zix 595 8 patient patient NN cord-007788-09t52zix 595 9 should should MD cord-007788-09t52zix 595 10 be be VB cord-007788-09t52zix 595 11 offered offer VBN cord-007788-09t52zix 595 12 psychological psychological JJ cord-007788-09t52zix 595 13 support support NN cord-007788-09t52zix 595 14 as as RB cord-007788-09t52zix 595 15 well well RB cord-007788-09t52zix 595 16 as as IN cord-007788-09t52zix 595 17 assistance assistance NN cord-007788-09t52zix 595 18 with with IN cord-007788-09t52zix 595 19 positioning positioning NN cord-007788-09t52zix 595 20 and and CC cord-007788-09t52zix 595 21 breathing breathing NN cord-007788-09t52zix 595 22 techniques technique NNS cord-007788-09t52zix 595 23 and and CC cord-007788-09t52zix 595 24 exercises exercise NNS cord-007788-09t52zix 595 25 . . . cord-007788-09t52zix 596 1 Medication medication NN cord-007788-09t52zix 596 2 for for IN cord-007788-09t52zix 596 3 anxiety anxiety NN cord-007788-09t52zix 596 4 may may MD cord-007788-09t52zix 596 5 be be VB cord-007788-09t52zix 596 6 necessary necessary JJ cord-007788-09t52zix 596 7 . . . cord-007788-09t52zix 597 1 Referral referral NN cord-007788-09t52zix 597 2 to to IN cord-007788-09t52zix 597 3 a a DT cord-007788-09t52zix 597 4 physiotherapist physiotherapist NN cord-007788-09t52zix 597 5 , , , cord-007788-09t52zix 597 6 respiratory respiratory JJ cord-007788-09t52zix 597 7 therapist therapist NN cord-007788-09t52zix 597 8 or or CC cord-007788-09t52zix 597 9 other other JJ cord-007788-09t52zix 597 10 staff staff NN cord-007788-09t52zix 597 11 with with IN cord-007788-09t52zix 597 12 expertise expertise NN cord-007788-09t52zix 597 13 in in IN cord-007788-09t52zix 597 14 pulmonary pulmonary JJ cord-007788-09t52zix 597 15 diseases disease NNS cord-007788-09t52zix 597 16 should should MD cord-007788-09t52zix 597 17 be be VB cord-007788-09t52zix 597 18 made make VBN cord-007788-09t52zix 597 19 for for IN cord-007788-09t52zix 597 20 advice advice NN cord-007788-09t52zix 597 21 on on IN cord-007788-09t52zix 597 22 tools tool NNS cord-007788-09t52zix 597 23 and and CC cord-007788-09t52zix 597 24 exercises exercise NNS cord-007788-09t52zix 597 25 that that WDT cord-007788-09t52zix 597 26 may may MD cord-007788-09t52zix 597 27 help help VB cord-007788-09t52zix 597 28 the the DT cord-007788-09t52zix 597 29 patient patient NN cord-007788-09t52zix 597 30 to to TO cord-007788-09t52zix 597 31 maintain maintain VB cord-007788-09t52zix 597 32 pulmonary pulmonary JJ cord-007788-09t52zix 597 33 function function NN cord-007788-09t52zix 597 34 and and CC cord-007788-09t52zix 597 35 prevent prevent VBP cord-007788-09t52zix 597 36 worsening worsen VBG cord-007788-09t52zix 597 37 of of IN cord-007788-09t52zix 597 38 the the DT cord-007788-09t52zix 597 39 condition condition NN cord-007788-09t52zix 597 40 . . . cord-007788-09t52zix 598 1 If if IN cord-007788-09t52zix 598 2 the the DT cord-007788-09t52zix 598 3 condition condition NN cord-007788-09t52zix 598 4 shows show VBZ cord-007788-09t52zix 598 5 no no DT cord-007788-09t52zix 598 6 signs sign NNS cord-007788-09t52zix 598 7 of of IN cord-007788-09t52zix 598 8 improving improve VBG cord-007788-09t52zix 598 9 , , , cord-007788-09t52zix 598 10 the the DT cord-007788-09t52zix 598 11 patient patient NN cord-007788-09t52zix 598 12 should should MD cord-007788-09t52zix 598 13 be be VB cord-007788-09t52zix 598 14 prepared prepare VBN cord-007788-09t52zix 598 15 for for IN cord-007788-09t52zix 598 16 transfer transfer NN cord-007788-09t52zix 598 17 to to IN cord-007788-09t52zix 598 18 the the DT cord-007788-09t52zix 598 19 ICU ICU NNP cord-007788-09t52zix 598 20 . . . cord-007788-09t52zix 599 1 Identification identification NN cord-007788-09t52zix 599 2 of of IN cord-007788-09t52zix 599 3 patients patient NNS cord-007788-09t52zix 599 4 at at IN cord-007788-09t52zix 599 5 risk risk NN cord-007788-09t52zix 599 6 , , , cord-007788-09t52zix 599 7 prompt prompt JJ cord-007788-09t52zix 599 8 intervention intervention NN cord-007788-09t52zix 599 9 to to IN cord-007788-09t52zix 599 10 signs sign NNS cord-007788-09t52zix 599 11 and and CC cord-007788-09t52zix 599 12 symptoms symptom NNS cord-007788-09t52zix 599 13 of of IN cord-007788-09t52zix 599 14 pulmonary pulmonary JJ cord-007788-09t52zix 599 15 dysfunction dysfunction NN cord-007788-09t52zix 599 16 and and CC cord-007788-09t52zix 599 17 close close JJ cord-007788-09t52zix 599 18 collaboration collaboration NN cord-007788-09t52zix 599 19 within within IN cord-007788-09t52zix 599 20 the the DT cord-007788-09t52zix 599 21 team team NN cord-007788-09t52zix 599 22 will will MD cord-007788-09t52zix 599 23 increase increase VB cord-007788-09t52zix 599 24 the the DT cord-007788-09t52zix 599 25 chances chance NNS cord-007788-09t52zix 599 26 of of IN cord-007788-09t52zix 599 27 a a DT cord-007788-09t52zix 599 28 positive positive JJ cord-007788-09t52zix 599 29 outcome outcome NN cord-007788-09t52zix 599 30 . . . cord-007788-09t52zix 600 1 Diffuse Diffuse NNP cord-007788-09t52zix 600 2 Alveolar Alveolar NNP cord-007788-09t52zix 601 1 Haemorrhage Haemorrhage NNP cord-007788-09t52zix 601 2 Diffuse Diffuse NNP cord-007788-09t52zix 601 3 Alveolar Alveolar NNP cord-007788-09t52zix 601 4 Haemorrhage Haemorrhage NNP cord-007788-09t52zix 601 5 ( ( -LRB- cord-007788-09t52zix 601 6 DAH DAH NNP cord-007788-09t52zix 601 7 ) ) -RRB- cord-007788-09t52zix 601 8 is be VBZ cord-007788-09t52zix 601 9 a a DT cord-007788-09t52zix 601 10 noninfectious noninfectious JJ cord-007788-09t52zix 601 11 pulmonary pulmonary JJ cord-007788-09t52zix 601 12 complication complication NN cord-007788-09t52zix 601 13 associated associate VBN cord-007788-09t52zix 601 14 with with IN cord-007788-09t52zix 601 15 haematopoietic haematopoietic JJ cord-007788-09t52zix 601 16 stem stem NN cord-007788-09t52zix 601 17 cell cell NN cord-007788-09t52zix 601 18 transplant transplant NN cord-007788-09t52zix 601 19 ( ( -LRB- cord-007788-09t52zix 601 20 HSCT HSCT NNP cord-007788-09t52zix 601 21 ) ) -RRB- cord-007788-09t52zix 601 22 and and CC cord-007788-09t52zix 601 23 other other JJ cord-007788-09t52zix 601 24 causes cause NNS cord-007788-09t52zix 601 25 ( ( -LRB- cord-007788-09t52zix 601 26 Park Park NNP cord-007788-09t52zix 601 27 2013 2013 CD cord-007788-09t52zix 601 28 ) ) -RRB- cord-007788-09t52zix 601 29 . . . cord-007788-09t52zix 602 1 It -PRON- PRP cord-007788-09t52zix 602 2 is be VBZ cord-007788-09t52zix 602 3 differentiated differentiate VBN cord-007788-09t52zix 602 4 from from IN cord-007788-09t52zix 602 5 idiopathic idiopathic JJ cord-007788-09t52zix 602 6 pneumonia pneumonia NN cord-007788-09t52zix 602 7 syndrome syndrome NN cord-007788-09t52zix 602 8 ( ( -LRB- cord-007788-09t52zix 602 9 IPS IPS NNP cord-007788-09t52zix 602 10 ) ) -RRB- cord-007788-09t52zix 602 11 through through IN cord-007788-09t52zix 602 12 confirmation confirmation NN cord-007788-09t52zix 602 13 of of IN cord-007788-09t52zix 602 14 pulmonary pulmonary JJ cord-007788-09t52zix 602 15 haemorrhage haemorrhage NN cord-007788-09t52zix 602 16 by by IN cord-007788-09t52zix 602 17 bronchoscopy bronchoscopy NN cord-007788-09t52zix 602 18 and and CC cord-007788-09t52zix 602 19 bronchoalveolar bronchoalveolar NNP cord-007788-09t52zix 602 20 lavage lavage NNP cord-007788-09t52zix 602 21 ( ( -LRB- cord-007788-09t52zix 602 22 BAL BAL NNP cord-007788-09t52zix 602 23 ) ) -RRB- cord-007788-09t52zix 602 24 . . . cord-007788-09t52zix 603 1 The the DT cord-007788-09t52zix 603 2 bleeding bleeding NN cord-007788-09t52zix 603 3 can can MD cord-007788-09t52zix 603 4 be be VB cord-007788-09t52zix 603 5 either either CC cord-007788-09t52zix 603 6 insidious insidious JJ cord-007788-09t52zix 603 7 , , , cord-007788-09t52zix 603 8 causing cause VBG cord-007788-09t52zix 603 9 a a DT cord-007788-09t52zix 603 10 gradual gradual JJ cord-007788-09t52zix 603 11 pulmonary pulmonary JJ cord-007788-09t52zix 603 12 dysfunction dysfunction NN cord-007788-09t52zix 603 13 , , , cord-007788-09t52zix 603 14 or or CC cord-007788-09t52zix 603 15 a a DT cord-007788-09t52zix 603 16 more more RBR cord-007788-09t52zix 603 17 acute acute JJ cord-007788-09t52zix 603 18 bleeding bleeding NN cord-007788-09t52zix 603 19 into into IN cord-007788-09t52zix 603 20 the the DT cord-007788-09t52zix 603 21 alveolar alveolar JJ cord-007788-09t52zix 603 22 space space NN cord-007788-09t52zix 603 23 . . . cord-007788-09t52zix 604 1 Damage damage NN cord-007788-09t52zix 604 2 to to IN cord-007788-09t52zix 604 3 the the DT cord-007788-09t52zix 604 4 alveolar alveolar NN cord-007788-09t52zix 604 5 - - HYPH cord-007788-09t52zix 604 6 capillary capillary JJ cord-007788-09t52zix 604 7 barrier barrier NN cord-007788-09t52zix 604 8 from from IN cord-007788-09t52zix 604 9 conditioning conditioning NN cord-007788-09t52zix 604 10 treatment treatment NN cord-007788-09t52zix 604 11 and and CC cord-007788-09t52zix 604 12 the the DT cord-007788-09t52zix 604 13 engraftment engraftment NN cord-007788-09t52zix 604 14 process process NN cord-007788-09t52zix 604 15 with with IN cord-007788-09t52zix 604 16 recovery recovery NN cord-007788-09t52zix 604 17 of of IN cord-007788-09t52zix 604 18 neutrophils neutrophil NNS cord-007788-09t52zix 604 19 leads lead VBZ cord-007788-09t52zix 604 20 to to IN cord-007788-09t52zix 604 21 entry entry NN cord-007788-09t52zix 604 22 of of IN cord-007788-09t52zix 604 23 blood blood NN cord-007788-09t52zix 604 24 into into IN cord-007788-09t52zix 604 25 the the DT cord-007788-09t52zix 604 26 alveolar alveolar JJ cord-007788-09t52zix 604 27 space space NN cord-007788-09t52zix 604 28 . . . cord-007788-09t52zix 605 1 An an DT cord-007788-09t52zix 605 2 approximate approximate JJ cord-007788-09t52zix 605 3 incidence incidence NN cord-007788-09t52zix 605 4 of of IN cord-007788-09t52zix 605 5 around around IN cord-007788-09t52zix 605 6 5 5 CD cord-007788-09t52zix 605 7 % % NN cord-007788-09t52zix 605 8 up up IN cord-007788-09t52zix 605 9 to to TO cord-007788-09t52zix 605 10 20 20 CD cord-007788-09t52zix 605 11 % % NN cord-007788-09t52zix 605 12 , , , cord-007788-09t52zix 605 13 with with IN cord-007788-09t52zix 605 14 a a DT cord-007788-09t52zix 605 15 mortality mortality NN cord-007788-09t52zix 605 16 rate rate NN cord-007788-09t52zix 605 17 ranging range VBG cord-007788-09t52zix 605 18 between between IN cord-007788-09t52zix 605 19 50 50 CD cord-007788-09t52zix 605 20 % % NN cord-007788-09t52zix 605 21 and and CC cord-007788-09t52zix 605 22 100 100 CD cord-007788-09t52zix 605 23 % % NN cord-007788-09t52zix 605 24 , , , cord-007788-09t52zix 605 25 has have VBZ cord-007788-09t52zix 605 26 been be VBN cord-007788-09t52zix 605 27 reported report VBN cord-007788-09t52zix 605 28 for for IN cord-007788-09t52zix 605 29 DAH DAH NNP cord-007788-09t52zix 605 30 in in IN cord-007788-09t52zix 605 31 HSCT HSCT NNP cord-007788-09t52zix 605 32 recipients recipient NNS cord-007788-09t52zix 605 33 ( ( -LRB- cord-007788-09t52zix 605 34 Afessa Afessa NNP cord-007788-09t52zix 605 35 et et NNP cord-007788-09t52zix 605 36 al al NNP cord-007788-09t52zix 605 37 . . NNP cord-007788-09t52zix 605 38 2002 2002 CD cord-007788-09t52zix 605 39 ; ; : cord-007788-09t52zix 605 40 Majhail Majhail NNP cord-007788-09t52zix 605 41 et et NNP cord-007788-09t52zix 605 42 al al NNP cord-007788-09t52zix 605 43 . . . cord-007788-09t52zix 606 1 2006 2006 CD cord-007788-09t52zix 606 2 ; ; : cord-007788-09t52zix 606 3 Carreras Carreras NNP cord-007788-09t52zix 606 4 2012 2012 CD cord-007788-09t52zix 606 5 ) ) -RRB- cord-007788-09t52zix 606 6 . . . cord-007788-09t52zix 607 1 The the DT cord-007788-09t52zix 607 2 incidence incidence NN cord-007788-09t52zix 607 3 is be VBZ cord-007788-09t52zix 607 4 similar similar JJ cord-007788-09t52zix 607 5 between between IN cord-007788-09t52zix 607 6 auto auto NN cord-007788-09t52zix 607 7 - - : cord-007788-09t52zix 607 8 and and CC cord-007788-09t52zix 607 9 allo allo NN cord-007788-09t52zix 607 10 - - HYPH cord-007788-09t52zix 607 11 HSCT HSCT NNP cord-007788-09t52zix 607 12 . . . cord-007788-09t52zix 608 1 The the DT cord-007788-09t52zix 608 2 implication implication NN cord-007788-09t52zix 608 3 of of IN cord-007788-09t52zix 608 4 prognostic prognostic JJ cord-007788-09t52zix 608 5 factors factor NNS cord-007788-09t52zix 608 6 has have VBZ cord-007788-09t52zix 608 7 not not RB cord-007788-09t52zix 608 8 been be VBN cord-007788-09t52zix 608 9 well well RB cord-007788-09t52zix 608 10 studied study VBN cord-007788-09t52zix 608 11 , , , cord-007788-09t52zix 608 12 but but CC cord-007788-09t52zix 608 13 early early JJ cord-007788-09t52zix 608 14 - - HYPH cord-007788-09t52zix 608 15 onset onset NN cord-007788-09t52zix 608 16 DAH dah NN cord-007788-09t52zix 608 17 ( ( -LRB- cord-007788-09t52zix 608 18 within within IN cord-007788-09t52zix 608 19 the the DT cord-007788-09t52zix 608 20 first first JJ cord-007788-09t52zix 608 21 30 30 CD cord-007788-09t52zix 608 22 days day NNS cord-007788-09t52zix 608 23 after after IN cord-007788-09t52zix 608 24 transplant transplant NN cord-007788-09t52zix 608 25 ) ) -RRB- cord-007788-09t52zix 608 26 in in IN cord-007788-09t52zix 608 27 patients patient NNS cord-007788-09t52zix 608 28 undergoing undergo VBG cord-007788-09t52zix 608 29 auto auto NN cord-007788-09t52zix 608 30 - - HYPH cord-007788-09t52zix 608 31 HSCT HSCT NNP cord-007788-09t52zix 608 32 has have VBZ cord-007788-09t52zix 608 33 a a DT cord-007788-09t52zix 608 34 favourable favourable JJ cord-007788-09t52zix 608 35 prognosis prognosis NN cord-007788-09t52zix 608 36 . . . cord-007788-09t52zix 609 1 Risk risk NN cord-007788-09t52zix 609 2 factors factor NNS cord-007788-09t52zix 609 3 for for IN cord-007788-09t52zix 609 4 the the DT cord-007788-09t52zix 609 5 development development NN cord-007788-09t52zix 609 6 of of IN cord-007788-09t52zix 609 7 DAH DAH NNP cord-007788-09t52zix 609 8 in in IN cord-007788-09t52zix 609 9 HSCT HSCT NNP cord-007788-09t52zix 609 10 recipients recipient NNS cord-007788-09t52zix 609 11 include include VBP cord-007788-09t52zix 609 12 : : : cord-007788-09t52zix 610 1 • • NNP cord-007788-09t52zix 611 1 Older old JJR cord-007788-09t52zix 611 2 age age NN cord-007788-09t52zix 612 1 • • NNP cord-007788-09t52zix 613 1 Total total JJ cord-007788-09t52zix 613 2 body body NN cord-007788-09t52zix 613 3 irradiation irradiation NN cord-007788-09t52zix 613 4 ( ( -LRB- cord-007788-09t52zix 613 5 TBI TBI NNP cord-007788-09t52zix 613 6 ) ) -RRB- cord-007788-09t52zix 614 1 • • NNP cord-007788-09t52zix 615 1 Myeloablative Myeloablative NNP cord-007788-09t52zix 615 2 conditioning conditioning NN cord-007788-09t52zix 615 3 ( ( -LRB- cord-007788-09t52zix 615 4 MAC MAC NNP cord-007788-09t52zix 615 5 ) ) -RRB- cord-007788-09t52zix 615 6 regimens regimen NNS cord-007788-09t52zix 615 7 • • XX cord-007788-09t52zix 616 1 Acute acute JJ cord-007788-09t52zix 616 2 graft graft NN cord-007788-09t52zix 616 3 versus versus IN cord-007788-09t52zix 617 1 host host NNP cord-007788-09t52zix 617 2 ( ( -LRB- cord-007788-09t52zix 617 3 aGvHD agvhd NN cord-007788-09t52zix 617 4 ) ) -RRB- cord-007788-09t52zix 617 5 disease disease NN cord-007788-09t52zix 617 6 Dyspnoea Dyspnoea NNP cord-007788-09t52zix 617 7 , , , cord-007788-09t52zix 617 8 dry dry JJ cord-007788-09t52zix 617 9 cough cough NN cord-007788-09t52zix 617 10 and and CC cord-007788-09t52zix 617 11 fever fever NN cord-007788-09t52zix 617 12 are be VBP cord-007788-09t52zix 617 13 the the DT cord-007788-09t52zix 617 14 most most RBS cord-007788-09t52zix 617 15 common common JJ cord-007788-09t52zix 617 16 complaints complaint NNS cord-007788-09t52zix 617 17 . . . cord-007788-09t52zix 618 1 Haemoptysis Haemoptysis NNP cord-007788-09t52zix 618 2 is be VBZ cord-007788-09t52zix 618 3 rarely rarely RB cord-007788-09t52zix 618 4 observed observe VBN cord-007788-09t52zix 618 5 in in IN cord-007788-09t52zix 618 6 HSCT HSCT NNP cord-007788-09t52zix 618 7 recipients recipient NNS cord-007788-09t52zix 618 8 . . . cord-007788-09t52zix 619 1 Hypoxemia Hypoxemia NNP cord-007788-09t52zix 619 2 may may MD cord-007788-09t52zix 619 3 be be VB cord-007788-09t52zix 619 4 present present JJ cord-007788-09t52zix 619 5 and and CC cord-007788-09t52zix 619 6 diffuse diffuse JJ cord-007788-09t52zix 619 7 or or CC cord-007788-09t52zix 619 8 focal focal JJ cord-007788-09t52zix 619 9 interstitial interstitial JJ cord-007788-09t52zix 619 10 or or CC cord-007788-09t52zix 619 11 alveolar alveolar NN cord-007788-09t52zix 619 12 infiltrates infiltrate NNS cord-007788-09t52zix 619 13 can can MD cord-007788-09t52zix 619 14 be be VB cord-007788-09t52zix 619 15 found find VBN cord-007788-09t52zix 619 16 on on IN cord-007788-09t52zix 619 17 chest chest NN cord-007788-09t52zix 619 18 X x NN cord-007788-09t52zix 619 19 - - NN cord-007788-09t52zix 619 20 ray ray NN cord-007788-09t52zix 619 21 or or CC cord-007788-09t52zix 619 22 computed compute VBN cord-007788-09t52zix 619 23 tomography tomography NN cord-007788-09t52zix 619 24 ( ( -LRB- cord-007788-09t52zix 619 25 CT CT NNP cord-007788-09t52zix 619 26 ) ) -RRB- cord-007788-09t52zix 619 27 scan scan NN cord-007788-09t52zix 619 28 . . . cord-007788-09t52zix 620 1 With with IN cord-007788-09t52zix 620 2 such such JJ cord-007788-09t52zix 620 3 findings finding NNS cord-007788-09t52zix 620 4 , , , cord-007788-09t52zix 620 5 bronchoscopy bronchoscopy RB cord-007788-09t52zix 620 6 with with IN cord-007788-09t52zix 620 7 BAL BAL NNP cord-007788-09t52zix 620 8 and and CC cord-007788-09t52zix 620 9 transbronchial transbronchial JJ cord-007788-09t52zix 620 10 biopsy biopsy NN cord-007788-09t52zix 620 11 is be VBZ cord-007788-09t52zix 620 12 indicated indicate VBN cord-007788-09t52zix 620 13 although although IN cord-007788-09t52zix 620 14 performing perform VBG cord-007788-09t52zix 620 15 these these DT cord-007788-09t52zix 620 16 invasive invasive JJ cord-007788-09t52zix 620 17 tests test NNS cord-007788-09t52zix 620 18 in in IN cord-007788-09t52zix 620 19 patients patient NNS cord-007788-09t52zix 620 20 with with IN cord-007788-09t52zix 620 21 severe severe JJ cord-007788-09t52zix 620 22 illness illness NN cord-007788-09t52zix 620 23 , , , cord-007788-09t52zix 620 24 and and CC cord-007788-09t52zix 620 25 unstable unstable JJ cord-007788-09t52zix 620 26 respiratory respiratory JJ cord-007788-09t52zix 620 27 status status NN cord-007788-09t52zix 620 28 is be VBZ cord-007788-09t52zix 620 29 a a DT cord-007788-09t52zix 620 30 challenge challenge NN cord-007788-09t52zix 620 31 . . . cord-007788-09t52zix 621 1 The the DT cord-007788-09t52zix 621 2 diagnosis diagnosis NN cord-007788-09t52zix 621 3 is be VBZ cord-007788-09t52zix 621 4 based base VBN cord-007788-09t52zix 621 5 on on IN cord-007788-09t52zix 621 6 BAL BAL NNP cord-007788-09t52zix 621 7 findings finding NNS cord-007788-09t52zix 621 8 which which WDT cord-007788-09t52zix 621 9 become become VBP cord-007788-09t52zix 621 10 progressively progressively RB cord-007788-09t52zix 621 11 more more JJR cord-007788-09t52zix 621 12 blood blood NN cord-007788-09t52zix 621 13 stained stain VBN cord-007788-09t52zix 621 14 , , , cord-007788-09t52zix 621 15 indicating indicate VBG cord-007788-09t52zix 621 16 blood blood NN cord-007788-09t52zix 621 17 in in IN cord-007788-09t52zix 621 18 the the DT cord-007788-09t52zix 621 19 alveoli alveolus NNS cord-007788-09t52zix 621 20 . . . cord-007788-09t52zix 622 1 Other other JJ cord-007788-09t52zix 622 2 causes cause NNS cord-007788-09t52zix 622 3 , , , cord-007788-09t52zix 622 4 such such JJ cord-007788-09t52zix 622 5 as as IN cord-007788-09t52zix 622 6 heart heart NN cord-007788-09t52zix 622 7 failure failure NN cord-007788-09t52zix 622 8 and and CC cord-007788-09t52zix 622 9 fluid fluid JJ cord-007788-09t52zix 622 10 overload overload NN cord-007788-09t52zix 622 11 , , , cord-007788-09t52zix 622 12 should should MD cord-007788-09t52zix 622 13 be be VB cord-007788-09t52zix 622 14 excluded exclude VBN cord-007788-09t52zix 622 15 . . . cord-007788-09t52zix 623 1 Infection infection NN cord-007788-09t52zix 623 2 needs need VBZ cord-007788-09t52zix 623 3 to to TO cord-007788-09t52zix 623 4 be be VB cord-007788-09t52zix 623 5 ruled rule VBN cord-007788-09t52zix 623 6 out out RP cord-007788-09t52zix 623 7 by by IN cord-007788-09t52zix 623 8 obtaining obtain VBG cord-007788-09t52zix 623 9 relevant relevant JJ cord-007788-09t52zix 623 10 cultures culture NNS cord-007788-09t52zix 623 11 . . . cord-007788-09t52zix 624 1 Presence presence NN cord-007788-09t52zix 624 2 of of IN cord-007788-09t52zix 624 3 hemosiderin hemosiderin NNP cord-007788-09t52zix 624 4 - - HYPH cord-007788-09t52zix 624 5 laden laden JJ cord-007788-09t52zix 624 6 macrophages macrophage NNS cord-007788-09t52zix 624 7 in in IN cord-007788-09t52zix 624 8 BAL bal NN cord-007788-09t52zix 624 9 fluid fluid NN cord-007788-09t52zix 624 10 is be VBZ cord-007788-09t52zix 624 11 not not RB cord-007788-09t52zix 624 12 diagnostic diagnostic JJ cord-007788-09t52zix 624 13 for for IN cord-007788-09t52zix 624 14 DAH DAH NNP cord-007788-09t52zix 624 15 but but CC cord-007788-09t52zix 624 16 may may MD cord-007788-09t52zix 624 17 support support VB cord-007788-09t52zix 624 18 the the DT cord-007788-09t52zix 624 19 diagnosis diagnosis NN cord-007788-09t52zix 624 20 . . . cord-007788-09t52zix 625 1 It -PRON- PRP cord-007788-09t52zix 625 2 is be VBZ cord-007788-09t52zix 625 3 often often RB cord-007788-09t52zix 625 4 very very RB cord-007788-09t52zix 625 5 difficult difficult JJ cord-007788-09t52zix 625 6 to to TO cord-007788-09t52zix 625 7 differentiate differentiate VB cord-007788-09t52zix 625 8 DAH DAH NNP cord-007788-09t52zix 625 9 from from IN cord-007788-09t52zix 625 10 IPS IPS NNP cord-007788-09t52zix 625 11 and and CC cord-007788-09t52zix 625 12 the the DT cord-007788-09t52zix 625 13 ES ES NNP cord-007788-09t52zix 625 14 form form NN cord-007788-09t52zix 625 15 of of IN cord-007788-09t52zix 625 16 respiratory respiratory JJ cord-007788-09t52zix 625 17 distress distress NN cord-007788-09t52zix 625 18 ( ( -LRB- cord-007788-09t52zix 625 19 PERDS PERDS NNP cord-007788-09t52zix 625 20 ) ) -RRB- cord-007788-09t52zix 625 21 . . . cord-007788-09t52zix 626 1 IPS IPS NNP cord-007788-09t52zix 626 2 is be VBZ cord-007788-09t52zix 626 3 more more RBR cord-007788-09t52zix 626 4 common common JJ cord-007788-09t52zix 626 5 in in IN cord-007788-09t52zix 626 6 allo allo NN cord-007788-09t52zix 626 7 - - HYPH cord-007788-09t52zix 626 8 HSCT HSCT NNP cord-007788-09t52zix 626 9 , , , cord-007788-09t52zix 626 10 after after IN cord-007788-09t52zix 626 11 engraftment engraftment NN cord-007788-09t52zix 626 12 , , , cord-007788-09t52zix 626 13 and and CC cord-007788-09t52zix 626 14 does do VBZ cord-007788-09t52zix 626 15 not not RB cord-007788-09t52zix 626 16 respond respond VB cord-007788-09t52zix 626 17 to to IN cord-007788-09t52zix 626 18 corticosteroids corticosteroid NNS cord-007788-09t52zix 626 19 and and CC cord-007788-09t52zix 626 20 has have VBZ cord-007788-09t52zix 626 21 a a DT cord-007788-09t52zix 626 22 more more RBR cord-007788-09t52zix 626 23 progressive progressive JJ cord-007788-09t52zix 626 24 nature nature NN cord-007788-09t52zix 626 25 . . . cord-007788-09t52zix 627 1 In in IN cord-007788-09t52zix 627 2 PERDS PERDS NNP cord-007788-09t52zix 627 3 the the DT cord-007788-09t52zix 627 4 majority majority NN cord-007788-09t52zix 627 5 of of IN cord-007788-09t52zix 627 6 patients patient NNS cord-007788-09t52zix 627 7 do do VBP cord-007788-09t52zix 627 8 not not RB cord-007788-09t52zix 627 9 have have VB cord-007788-09t52zix 627 10 BAL BAL NNP cord-007788-09t52zix 627 11 findings finding NNS cord-007788-09t52zix 627 12 becoming become VBG cord-007788-09t52zix 627 13 progressively progressively RB cord-007788-09t52zix 627 14 bloodier bloody JJR cord-007788-09t52zix 627 15 . . . cord-007788-09t52zix 628 1 The the DT cord-007788-09t52zix 628 2 mean mean JJ cord-007788-09t52zix 628 3 onset onset NN cord-007788-09t52zix 628 4 of of IN cord-007788-09t52zix 628 5 DAH DAH NNP cord-007788-09t52zix 628 6 has have VBZ cord-007788-09t52zix 628 7 been be VBN cord-007788-09t52zix 628 8 reported report VBN cord-007788-09t52zix 628 9 on on IN cord-007788-09t52zix 628 10 day day NN cord-007788-09t52zix 628 11 24 24 CD cord-007788-09t52zix 628 12 after after IN cord-007788-09t52zix 628 13 transplant transplant NN cord-007788-09t52zix 628 14 and and CC cord-007788-09t52zix 628 15 6 6 CD cord-007788-09t52zix 628 16 days day NNS cord-007788-09t52zix 628 17 after after IN cord-007788-09t52zix 628 18 absolute absolute JJ cord-007788-09t52zix 628 19 neutrophil neutrophil NN cord-007788-09t52zix 628 20 count count NN cord-007788-09t52zix 628 21 ( ( -LRB- cord-007788-09t52zix 628 22 ANC ANC NNP cord-007788-09t52zix 628 23 ) ) -RRB- cord-007788-09t52zix 628 24 recovery recovery NN cord-007788-09t52zix 628 25 . . . cord-007788-09t52zix 629 1 Reversal reversal NN cord-007788-09t52zix 629 2 of of IN cord-007788-09t52zix 629 3 some some DT cord-007788-09t52zix 629 4 risk risk NN cord-007788-09t52zix 629 5 factors factor NNS cord-007788-09t52zix 629 6 , , , cord-007788-09t52zix 629 7 e.g. e.g. IN cord-007788-09t52zix 629 8 choice choice NN cord-007788-09t52zix 629 9 of of IN cord-007788-09t52zix 629 10 conditioning conditioning NN cord-007788-09t52zix 629 11 treatment treatment NN cord-007788-09t52zix 629 12 , , , cord-007788-09t52zix 629 13 may may MD cord-007788-09t52zix 629 14 be be VB cord-007788-09t52zix 629 15 possible possible JJ cord-007788-09t52zix 629 16 , , , cord-007788-09t52zix 629 17 but but CC cord-007788-09t52zix 629 18 otherwise otherwise RB cord-007788-09t52zix 629 19 no no DT cord-007788-09t52zix 629 20 prophylaxis prophylaxis NN cord-007788-09t52zix 629 21 exists exist VBZ cord-007788-09t52zix 629 22 . . . cord-007788-09t52zix 630 1 High high JJ cord-007788-09t52zix 630 2 - - HYPH cord-007788-09t52zix 630 3 dose dose NN cord-007788-09t52zix 630 4 corticosteroids corticosteroid NNS cord-007788-09t52zix 630 5 , , , cord-007788-09t52zix 630 6 using use VBG cord-007788-09t52zix 630 7 methyl methyl NN cord-007788-09t52zix 630 8 prednisolone prednisolone NN cord-007788-09t52zix 630 9 in in IN cord-007788-09t52zix 630 10 doses dose NNS cord-007788-09t52zix 630 11 of of IN cord-007788-09t52zix 630 12 250 250 CD cord-007788-09t52zix 630 13 - - SYM cord-007788-09t52zix 630 14 500 500 CD cord-007788-09t52zix 630 15 mg mg NN cord-007788-09t52zix 630 16 every every DT cord-007788-09t52zix 630 17 6 6 CD cord-007788-09t52zix 630 18 h h NN cord-007788-09t52zix 630 19 for for IN cord-007788-09t52zix 630 20 4 4 CD cord-007788-09t52zix 630 21 - - SYM cord-007788-09t52zix 630 22 5days 5days CD cord-007788-09t52zix 630 23 followed follow VBN cord-007788-09t52zix 630 24 by by IN cord-007788-09t52zix 630 25 slow slow JJ cord-007788-09t52zix 630 26 tapering tapering NN cord-007788-09t52zix 630 27 , , , cord-007788-09t52zix 630 28 is be VBZ cord-007788-09t52zix 630 29 considered consider VBN cord-007788-09t52zix 630 30 first first JJ cord-007788-09t52zix 630 31 - - HYPH cord-007788-09t52zix 630 32 line line NN cord-007788-09t52zix 630 33 treatment treatment NN cord-007788-09t52zix 630 34 even even RB cord-007788-09t52zix 630 35 if if IN cord-007788-09t52zix 630 36 efficacy efficacy NN cord-007788-09t52zix 630 37 can can MD cord-007788-09t52zix 630 38 be be VB cord-007788-09t52zix 630 39 questioned question VBN cord-007788-09t52zix 630 40 . . . cord-007788-09t52zix 631 1 With with IN cord-007788-09t52zix 631 2 early early JJ cord-007788-09t52zix 631 3 diagnosis diagnosis NN cord-007788-09t52zix 631 4 and and CC cord-007788-09t52zix 631 5 treatment treatment NN cord-007788-09t52zix 631 6 with with IN cord-007788-09t52zix 631 7 steroid steroid NN cord-007788-09t52zix 631 8 therapy therapy NN cord-007788-09t52zix 631 9 , , , cord-007788-09t52zix 631 10 respiratory respiratory JJ cord-007788-09t52zix 631 11 failure failure NN cord-007788-09t52zix 631 12 can can MD cord-007788-09t52zix 631 13 often often RB cord-007788-09t52zix 631 14 be be VB cord-007788-09t52zix 631 15 prevented prevent VBN cord-007788-09t52zix 631 16 . . . cord-007788-09t52zix 632 1 Noninvasive noninvasive JJ cord-007788-09t52zix 632 2 ventilation ventilation NN cord-007788-09t52zix 632 3 may may MD cord-007788-09t52zix 632 4 decrease decrease VB cord-007788-09t52zix 632 5 mortality mortality NN cord-007788-09t52zix 632 6 although although IN cord-007788-09t52zix 632 7 the the DT cord-007788-09t52zix 632 8 majority majority NN cord-007788-09t52zix 632 9 of of IN cord-007788-09t52zix 632 10 patients patient NNS cord-007788-09t52zix 632 11 with with IN cord-007788-09t52zix 632 12 DAH DAH NNP cord-007788-09t52zix 632 13 require require VB cord-007788-09t52zix 632 14 mechanical mechanical JJ cord-007788-09t52zix 632 15 ventilation ventilation NN cord-007788-09t52zix 632 16 , , , cord-007788-09t52zix 632 17 and and CC cord-007788-09t52zix 632 18 sepsis sepsis NN cord-007788-09t52zix 632 19 and and CC cord-007788-09t52zix 632 20 MOF MOF NNP cord-007788-09t52zix 632 21 / / SYM cord-007788-09t52zix 632 22 MOD MOD NNP cord-007788-09t52zix 632 23 will will MD cord-007788-09t52zix 632 24 cause cause VB cord-007788-09t52zix 632 25 death death NN cord-007788-09t52zix 632 26 in in IN cord-007788-09t52zix 632 27 a a DT cord-007788-09t52zix 632 28 large large JJ cord-007788-09t52zix 632 29 proportion proportion NN cord-007788-09t52zix 632 30 of of IN cord-007788-09t52zix 632 31 patients patient NNS cord-007788-09t52zix 632 32 ( ( -LRB- cord-007788-09t52zix 632 33 Rabe Rabe NNP cord-007788-09t52zix 632 34 et et NNP cord-007788-09t52zix 632 35 al al NNP cord-007788-09t52zix 632 36 . . NNP cord-007788-09t52zix 632 37 2010 2010 CD cord-007788-09t52zix 632 38 ) ) -RRB- cord-007788-09t52zix 632 39 . . . cord-007788-09t52zix 633 1 Other other JJ cord-007788-09t52zix 633 2 pharmacological pharmacological JJ cord-007788-09t52zix 633 3 therapies therapy NNS cord-007788-09t52zix 633 4 , , , cord-007788-09t52zix 633 5 as as RB cord-007788-09t52zix 633 6 well well RB cord-007788-09t52zix 633 7 as as IN cord-007788-09t52zix 633 8 plasma plasma NN cord-007788-09t52zix 633 9 exchange exchange NN cord-007788-09t52zix 633 10 , , , cord-007788-09t52zix 633 11 have have VBP cord-007788-09t52zix 633 12 been be VBN cord-007788-09t52zix 633 13 tried try VBN cord-007788-09t52zix 633 14 for for IN cord-007788-09t52zix 633 15 treatment treatment NN cord-007788-09t52zix 633 16 of of IN cord-007788-09t52zix 633 17 DAH DAH NNP cord-007788-09t52zix 633 18 . . . cord-007788-09t52zix 634 1 Recombinant recombinant JJ cord-007788-09t52zix 634 2 factor factor NN cord-007788-09t52zix 634 3 VIIa VIIa NNS cord-007788-09t52zix 634 4 ( ( -LRB- cord-007788-09t52zix 634 5 rFVIIa rfviia NN cord-007788-09t52zix 634 6 ) ) -RRB- cord-007788-09t52zix 634 7 has have VBZ cord-007788-09t52zix 634 8 been be VBN cord-007788-09t52zix 634 9 administered administer VBN cord-007788-09t52zix 634 10 and and CC cord-007788-09t52zix 634 11 achieved achieve VBN cord-007788-09t52zix 634 12 temporary temporary JJ cord-007788-09t52zix 634 13 control control NN cord-007788-09t52zix 634 14 of of IN cord-007788-09t52zix 634 15 bleeding bleed VBG cord-007788-09t52zix 634 16 . . . cord-007788-09t52zix 635 1 Tranexamic tranexamic JJ cord-007788-09t52zix 635 2 acid acid NN cord-007788-09t52zix 635 3 or or CC cord-007788-09t52zix 635 4 the the DT cord-007788-09t52zix 635 5 TNFα tnfα NN cord-007788-09t52zix 635 6 - - HYPH cord-007788-09t52zix 635 7 inhibitor inhibitor NN cord-007788-09t52zix 635 8 etanercept etanercept NNP cord-007788-09t52zix 635 9 have have VBP cord-007788-09t52zix 635 10 been be VBN cord-007788-09t52zix 635 11 used use VBN cord-007788-09t52zix 635 12 in in IN cord-007788-09t52zix 635 13 addition addition NN cord-007788-09t52zix 635 14 to to IN cord-007788-09t52zix 635 15 corticosteroids corticosteroid NNS cord-007788-09t52zix 635 16 but but CC cord-007788-09t52zix 635 17 have have VBP cord-007788-09t52zix 635 18 not not RB cord-007788-09t52zix 635 19 proved prove VBN cord-007788-09t52zix 635 20 to to TO cord-007788-09t52zix 635 21 be be VB cord-007788-09t52zix 635 22 effective effective JJ cord-007788-09t52zix 635 23 . . . cord-007788-09t52zix 636 1 Transfusion transfusion NN cord-007788-09t52zix 636 2 of of IN cord-007788-09t52zix 636 3 platelets platelet NNS cord-007788-09t52zix 636 4 and and CC cord-007788-09t52zix 636 5 red red JJ cord-007788-09t52zix 636 6 blood blood NN cord-007788-09t52zix 636 7 cells cell NNS cord-007788-09t52zix 636 8 ( ( -LRB- cord-007788-09t52zix 636 9 RBC RBC NNP cord-007788-09t52zix 636 10 ) ) -RRB- cord-007788-09t52zix 636 11 may may MD cord-007788-09t52zix 636 12 be be VB cord-007788-09t52zix 636 13 necessary necessary JJ cord-007788-09t52zix 636 14 . . . cord-007788-09t52zix 637 1 Patients patient NNS cord-007788-09t52zix 637 2 need need VBP cord-007788-09t52zix 637 3 frequent frequent JJ cord-007788-09t52zix 637 4 monitoring monitoring NN cord-007788-09t52zix 637 5 for for IN cord-007788-09t52zix 637 6 early early JJ cord-007788-09t52zix 637 7 detection detection NN cord-007788-09t52zix 637 8 of of IN cord-007788-09t52zix 637 9 any any DT cord-007788-09t52zix 637 10 pulmonary pulmonary JJ cord-007788-09t52zix 637 11 symptoms symptom NNS cord-007788-09t52zix 637 12 . . . cord-007788-09t52zix 638 1 Respiration respiration NN cord-007788-09t52zix 638 2 rate rate NN cord-007788-09t52zix 638 3 and and CC cord-007788-09t52zix 638 4 saturation saturation NN cord-007788-09t52zix 638 5 should should MD cord-007788-09t52zix 638 6 be be VB cord-007788-09t52zix 638 7 assessed assess VBN cord-007788-09t52zix 638 8 together together RB cord-007788-09t52zix 638 9 with with IN cord-007788-09t52zix 638 10 temperature temperature NN cord-007788-09t52zix 638 11 and and CC cord-007788-09t52zix 638 12 other other JJ cord-007788-09t52zix 638 13 standard standard JJ cord-007788-09t52zix 638 14 assessments assessment NNS cord-007788-09t52zix 638 15 . . . cord-007788-09t52zix 639 1 If if IN cord-007788-09t52zix 639 2 cough cough NN cord-007788-09t52zix 639 3 is be VBZ cord-007788-09t52zix 639 4 noted note VBN cord-007788-09t52zix 639 5 , , , cord-007788-09t52zix 639 6 this this DT cord-007788-09t52zix 639 7 should should MD cord-007788-09t52zix 639 8 be be VB cord-007788-09t52zix 639 9 reported report VBN cord-007788-09t52zix 639 10 to to IN cord-007788-09t52zix 639 11 the the DT cord-007788-09t52zix 639 12 team team NN cord-007788-09t52zix 639 13 and and CC cord-007788-09t52zix 639 14 the the DT cord-007788-09t52zix 639 15 treating treat VBG cord-007788-09t52zix 639 16 physician physician NN cord-007788-09t52zix 639 17 . . . cord-007788-09t52zix 640 1 Cultures culture NNS cord-007788-09t52zix 640 2 and and CC cord-007788-09t52zix 640 3 blood blood NN cord-007788-09t52zix 640 4 tests test NNS cord-007788-09t52zix 640 5 may may MD cord-007788-09t52zix 640 6 be be VB cord-007788-09t52zix 640 7 necessary necessary JJ cord-007788-09t52zix 640 8 to to TO cord-007788-09t52zix 640 9 rule rule VB cord-007788-09t52zix 640 10 out out RP cord-007788-09t52zix 640 11 infection infection NN cord-007788-09t52zix 640 12 . . . cord-007788-09t52zix 641 1 Cultures culture NNS cord-007788-09t52zix 641 2 should should MD cord-007788-09t52zix 641 3 be be VB cord-007788-09t52zix 641 4 performed perform VBN cord-007788-09t52zix 641 5 according accord VBG cord-007788-09t52zix 641 6 to to IN cord-007788-09t52zix 641 7 signs sign NNS cord-007788-09t52zix 641 8 and and CC cord-007788-09t52zix 641 9 symptoms symptom NNS cord-007788-09t52zix 641 10 , , , cord-007788-09t52zix 641 11 but but CC cord-007788-09t52zix 641 12 screening screening NN cord-007788-09t52zix 641 13 cultures culture NNS cord-007788-09t52zix 641 14 can can MD cord-007788-09t52zix 641 15 be be VB cord-007788-09t52zix 641 16 collected collect VBN cord-007788-09t52zix 641 17 to to TO cord-007788-09t52zix 641 18 possibly possibly RB cord-007788-09t52zix 641 19 enable enable VB cord-007788-09t52zix 641 20 detection detection NN cord-007788-09t52zix 641 21 of of IN cord-007788-09t52zix 641 22 occult occult JJ cord-007788-09t52zix 641 23 infection infection NN cord-007788-09t52zix 641 24 . . . cord-007788-09t52zix 642 1 The the DT cord-007788-09t52zix 642 2 patient patient NN cord-007788-09t52zix 642 3 's 's POS cord-007788-09t52zix 642 4 circulatory circulatory JJ cord-007788-09t52zix 642 5 status status NN cord-007788-09t52zix 642 6 and and CC cord-007788-09t52zix 642 7 fluid fluid JJ cord-007788-09t52zix 642 8 balance balance NN cord-007788-09t52zix 642 9 should should MD cord-007788-09t52zix 642 10 be be VB cord-007788-09t52zix 642 11 controlled control VBN cord-007788-09t52zix 642 12 by by IN cord-007788-09t52zix 642 13 monitoring monitor VBG cord-007788-09t52zix 642 14 pulse pulse NN cord-007788-09t52zix 642 15 , , , cord-007788-09t52zix 642 16 blood blood NN cord-007788-09t52zix 642 17 pressure pressure NN cord-007788-09t52zix 642 18 , , , cord-007788-09t52zix 642 19 weight weight NN cord-007788-09t52zix 642 20 and and CC cord-007788-09t52zix 642 21 input input NN cord-007788-09t52zix 642 22 and and CC cord-007788-09t52zix 642 23 output output NN cord-007788-09t52zix 642 24 . . . cord-007788-09t52zix 643 1 The the DT cord-007788-09t52zix 643 2 patient patient NN cord-007788-09t52zix 643 3 should should MD cord-007788-09t52zix 643 4 be be VB cord-007788-09t52zix 643 5 instructed instruct VBN cord-007788-09t52zix 643 6 to to TO cord-007788-09t52zix 643 7 report report VB cord-007788-09t52zix 643 8 all all DT cord-007788-09t52zix 643 9 symptoms symptom NNS cord-007788-09t52zix 643 10 , , , cord-007788-09t52zix 643 11 and and CC cord-007788-09t52zix 643 12 if if IN cord-007788-09t52zix 643 13 BAL BAL NNP cord-007788-09t52zix 643 14 and and CC cord-007788-09t52zix 643 15 lung lung NN cord-007788-09t52zix 643 16 biopsy biopsy NN cord-007788-09t52zix 643 17 will will MD cord-007788-09t52zix 643 18 be be VB cord-007788-09t52zix 643 19 performed perform VBN cord-007788-09t52zix 643 20 , , , cord-007788-09t52zix 643 21 patient patient JJ cord-007788-09t52zix 643 22 information information NN cord-007788-09t52zix 643 23 and and CC cord-007788-09t52zix 643 24 support support NN cord-007788-09t52zix 643 25 throughout throughout IN cord-007788-09t52zix 643 26 the the DT cord-007788-09t52zix 643 27 whole whole JJ cord-007788-09t52zix 643 28 procedure procedure NN cord-007788-09t52zix 643 29 is be VBZ cord-007788-09t52zix 643 30 vital vital JJ cord-007788-09t52zix 643 31 . . . cord-007788-09t52zix 644 1 Administration administration NN cord-007788-09t52zix 644 2 of of IN cord-007788-09t52zix 644 3 transfusions transfusion NNS cord-007788-09t52zix 644 4 , , , cord-007788-09t52zix 644 5 oxygen oxygen NN cord-007788-09t52zix 644 6 therapy therapy NN cord-007788-09t52zix 644 7 and and CC cord-007788-09t52zix 644 8 non non JJ cord-007788-09t52zix 644 9 - - JJ cord-007788-09t52zix 644 10 invasive invasive JJ cord-007788-09t52zix 644 11 ventilation ventilation NN cord-007788-09t52zix 644 12 should should MD cord-007788-09t52zix 644 13 be be VB cord-007788-09t52zix 644 14 performed perform VBN cord-007788-09t52zix 644 15 as as IN cord-007788-09t52zix 644 16 ordered order VBN cord-007788-09t52zix 644 17 and and CC cord-007788-09t52zix 644 18 since since IN cord-007788-09t52zix 644 19 dyspnoea dyspnoea NNS cord-007788-09t52zix 644 20 and and CC cord-007788-09t52zix 644 21 other other JJ cord-007788-09t52zix 644 22 breathing breathing NN cord-007788-09t52zix 644 23 difficulties difficulty NNS cord-007788-09t52zix 644 24 are be VBP cord-007788-09t52zix 644 25 associated associate VBN cord-007788-09t52zix 644 26 with with IN cord-007788-09t52zix 644 27 a a DT cord-007788-09t52zix 644 28 great great JJ cord-007788-09t52zix 644 29 deal deal NN cord-007788-09t52zix 644 30 of of IN cord-007788-09t52zix 644 31 anxiety anxiety NN cord-007788-09t52zix 644 32 patient patient JJ cord-007788-09t52zix 644 33 support support NN cord-007788-09t52zix 644 34 , , , cord-007788-09t52zix 644 35 sometimes sometimes RB cord-007788-09t52zix 644 36 with with IN cord-007788-09t52zix 644 37 pharmacological pharmacological JJ cord-007788-09t52zix 644 38 treatment treatment NN cord-007788-09t52zix 644 39 , , , cord-007788-09t52zix 644 40 is be VBZ cord-007788-09t52zix 644 41 crucial crucial JJ cord-007788-09t52zix 644 42 . . . cord-007788-09t52zix 645 1 Proper proper JJ cord-007788-09t52zix 645 2 positioning positioning NN cord-007788-09t52zix 645 3 together together RB cord-007788-09t52zix 645 4 with with IN cord-007788-09t52zix 645 5 breathing breathing NN cord-007788-09t52zix 645 6 exercises exercise NNS cord-007788-09t52zix 645 7 using use VBG cord-007788-09t52zix 645 8 appropriate appropriate JJ cord-007788-09t52zix 645 9 breathing breathing NN cord-007788-09t52zix 645 10 technique technique NN cord-007788-09t52zix 645 11 may may MD cord-007788-09t52zix 645 12 alleviate alleviate VB cord-007788-09t52zix 645 13 some some DT cord-007788-09t52zix 645 14 discomfort discomfort NN cord-007788-09t52zix 645 15 . . . cord-007788-09t52zix 646 1 During during IN cord-007788-09t52zix 646 2 high high JJ cord-007788-09t52zix 646 3 - - HYPH cord-007788-09t52zix 646 4 dose dose NN cord-007788-09t52zix 646 5 corticosteroid corticosteroid NN cord-007788-09t52zix 646 6 treatment treatment NN cord-007788-09t52zix 646 7 , , , cord-007788-09t52zix 646 8 blood blood NN cord-007788-09t52zix 646 9 glucose glucose NN cord-007788-09t52zix 646 10 should should MD cord-007788-09t52zix 646 11 be be VB cord-007788-09t52zix 646 12 monitored monitor VBN cord-007788-09t52zix 646 13 , , , cord-007788-09t52zix 646 14 and and CC cord-007788-09t52zix 646 15 it -PRON- PRP cord-007788-09t52zix 646 16 is be VBZ cord-007788-09t52zix 646 17 important important JJ cord-007788-09t52zix 646 18 to to TO cord-007788-09t52zix 646 19 be be VB cord-007788-09t52zix 646 20 alert alert JJ cord-007788-09t52zix 646 21 to to IN cord-007788-09t52zix 646 22 steroid steroid NN cord-007788-09t52zix 646 23 - - HYPH cord-007788-09t52zix 646 24 related relate VBN cord-007788-09t52zix 646 25 changes change NNS cord-007788-09t52zix 646 26 in in IN cord-007788-09t52zix 646 27 the the DT cord-007788-09t52zix 646 28 patient patient NN cord-007788-09t52zix 646 29 's 's POS cord-007788-09t52zix 646 30 mental mental JJ cord-007788-09t52zix 646 31 status status NN cord-007788-09t52zix 646 32 . . . cord-007788-09t52zix 647 1 Transplant transplant NN cord-007788-09t52zix 647 2 - - HYPH cord-007788-09t52zix 647 3 Associated Associated NNP cord-007788-09t52zix 647 4 Microangiopathy Microangiopathy NNP cord-007788-09t52zix 648 1 ( ( -LRB- cord-007788-09t52zix 648 2 TAM TAM NNP cord-007788-09t52zix 648 3 ) ) -RRB- cord-007788-09t52zix 648 4 Transplant transplant NN cord-007788-09t52zix 648 5 - - HYPH cord-007788-09t52zix 648 6 associated associate VBN cord-007788-09t52zix 648 7 microangiopathy microangiopathy NNP cord-007788-09t52zix 648 8 ( ( -LRB- cord-007788-09t52zix 648 9 TAM TAM NNP cord-007788-09t52zix 648 10 ) ) -RRB- cord-007788-09t52zix 648 11 is be VBZ cord-007788-09t52zix 648 12 also also RB cord-007788-09t52zix 648 13 known know VBN cord-007788-09t52zix 648 14 as as IN cord-007788-09t52zix 648 15 haematopoietic haematopoietic JJ cord-007788-09t52zix 648 16 stem stem NN cord-007788-09t52zix 648 17 cell cell NN cord-007788-09t52zix 648 18 transplantation transplantation NN cord-007788-09t52zix 648 19 ( ( -LRB- cord-007788-09t52zix 648 20 HSCT)-associated HSCT)-associated NNP cord-007788-09t52zix 648 21 thrombotic thrombotic JJ cord-007788-09t52zix 648 22 microangiopathy microangiopathy NNP cord-007788-09t52zix 648 23 ( ( -LRB- cord-007788-09t52zix 648 24 TA TA NNP cord-007788-09t52zix 648 25 - - HYPH cord-007788-09t52zix 648 26 TMA TMA NNP cord-007788-09t52zix 648 27 ) ) -RRB- cord-007788-09t52zix 648 28 . . . cord-007788-09t52zix 649 1 In in IN cord-007788-09t52zix 649 2 this this DT cord-007788-09t52zix 649 3 text text NN cord-007788-09t52zix 649 4 , , , cord-007788-09t52zix 649 5 the the DT cord-007788-09t52zix 649 6 term term NN cord-007788-09t52zix 649 7 TAM TAM NNP cord-007788-09t52zix 649 8 is be VBZ cord-007788-09t52zix 649 9 being be VBG cord-007788-09t52zix 649 10 used use VBN cord-007788-09t52zix 649 11 . . . cord-007788-09t52zix 650 1 TAM TAM NNP cord-007788-09t52zix 650 2 is be VBZ cord-007788-09t52zix 650 3 characterised characterise VBN cord-007788-09t52zix 650 4 by by IN cord-007788-09t52zix 650 5 microangiopathic microangiopathic JJ cord-007788-09t52zix 650 6 haemolytic haemolytic JJ cord-007788-09t52zix 650 7 anaemia anaemia NN cord-007788-09t52zix 650 8 with with IN cord-007788-09t52zix 650 9 schistocytes schistocyte NNS cord-007788-09t52zix 650 10 ( ( -LRB- cord-007788-09t52zix 650 11 fragmented fragmented JJ cord-007788-09t52zix 650 12 red red JJ cord-007788-09t52zix 650 13 blood blood NN cord-007788-09t52zix 650 14 cells cell NNS cord-007788-09t52zix 650 15 ) ) -RRB- cord-007788-09t52zix 650 16 and and CC cord-007788-09t52zix 650 17 thrombocytopenia thrombocytopenia NN cord-007788-09t52zix 650 18 from from IN cord-007788-09t52zix 650 19 platelet platelet NN cord-007788-09t52zix 650 20 consumption consumption NN cord-007788-09t52zix 650 21 . . . cord-007788-09t52zix 651 1 These these DT cord-007788-09t52zix 651 2 symptoms symptom NNS cord-007788-09t52zix 651 3 are be VBP cord-007788-09t52zix 651 4 due due JJ cord-007788-09t52zix 651 5 to to IN cord-007788-09t52zix 651 6 endothelial endothelial JJ cord-007788-09t52zix 651 7 dysfunction dysfunction NN cord-007788-09t52zix 651 8 causing cause VBG cord-007788-09t52zix 651 9 small small JJ cord-007788-09t52zix 651 10 vessels vessel NNS cord-007788-09t52zix 651 11 thrombosis thrombosis NN cord-007788-09t52zix 651 12 in in IN cord-007788-09t52zix 651 13 the the DT cord-007788-09t52zix 651 14 microcirculation microcirculation NN cord-007788-09t52zix 651 15 . . . cord-007788-09t52zix 652 1 TAM TAM NNP cord-007788-09t52zix 652 2 is be VBZ cord-007788-09t52zix 652 3 a a DT cord-007788-09t52zix 652 4 multi multi JJ cord-007788-09t52zix 652 5 - - JJ cord-007788-09t52zix 652 6 visceral visceral JJ cord-007788-09t52zix 652 7 disease disease NN cord-007788-09t52zix 652 8 most most RBS cord-007788-09t52zix 652 9 often often RB cord-007788-09t52zix 652 10 affecting affect VBG cord-007788-09t52zix 652 11 the the DT cord-007788-09t52zix 652 12 kidneys kidney NNS cord-007788-09t52zix 652 13 , , , cord-007788-09t52zix 652 14 but but CC cord-007788-09t52zix 652 15 pulmonary pulmonary JJ cord-007788-09t52zix 652 16 , , , cord-007788-09t52zix 652 17 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 652 18 and and CC cord-007788-09t52zix 652 19 central central JJ cord-007788-09t52zix 652 20 nervous nervous JJ cord-007788-09t52zix 652 21 system system NN cord-007788-09t52zix 652 22 ( ( -LRB- cord-007788-09t52zix 652 23 CNS CNS NNP cord-007788-09t52zix 652 24 ) ) -RRB- cord-007788-09t52zix 652 25 involvement involvement NN cord-007788-09t52zix 652 26 can can MD cord-007788-09t52zix 652 27 also also RB cord-007788-09t52zix 652 28 be be VB cord-007788-09t52zix 652 29 seen see VBN cord-007788-09t52zix 652 30 . . . cord-007788-09t52zix 653 1 Complement complement JJ cord-007788-09t52zix 653 2 system system NN cord-007788-09t52zix 653 3 dysregulation dysregulation NN cord-007788-09t52zix 653 4 plays play VBZ cord-007788-09t52zix 653 5 an an DT cord-007788-09t52zix 653 6 important important JJ cord-007788-09t52zix 653 7 role role NN cord-007788-09t52zix 653 8 in in IN cord-007788-09t52zix 653 9 the the DT cord-007788-09t52zix 653 10 severity severity NN cord-007788-09t52zix 653 11 of of IN cord-007788-09t52zix 653 12 TAM TAM NNP cord-007788-09t52zix 653 13 . . . cord-007788-09t52zix 654 1 Defects defect NNS cord-007788-09t52zix 654 2 in in IN cord-007788-09t52zix 654 3 the the DT cord-007788-09t52zix 654 4 complement complement NN cord-007788-09t52zix 654 5 system system NN cord-007788-09t52zix 654 6 lead lead VBP cord-007788-09t52zix 654 7 to to IN cord-007788-09t52zix 654 8 formation formation NN cord-007788-09t52zix 654 9 of of IN cord-007788-09t52zix 654 10 the the DT cord-007788-09t52zix 654 11 lytic lytic JJ cord-007788-09t52zix 654 12 complex complex NN cord-007788-09t52zix 655 1 C5b-9 C5b-9 NNP cord-007788-09t52zix 655 2 . . . cord-007788-09t52zix 656 1 This this DT cord-007788-09t52zix 656 2 complex complex NN cord-007788-09t52zix 656 3 can can MD cord-007788-09t52zix 656 4 be be VB cord-007788-09t52zix 656 5 detected detect VBN cord-007788-09t52zix 656 6 in in IN cord-007788-09t52zix 656 7 blood blood NN cord-007788-09t52zix 656 8 , , , cord-007788-09t52zix 656 9 and and CC cord-007788-09t52zix 656 10 an an DT cord-007788-09t52zix 656 11 increased increase VBN cord-007788-09t52zix 656 12 level level NN cord-007788-09t52zix 656 13 will will MD cord-007788-09t52zix 656 14 support support VB cord-007788-09t52zix 656 15 the the DT cord-007788-09t52zix 656 16 TAM tam NN cord-007788-09t52zix 656 17 diagnosis diagnosis NN cord-007788-09t52zix 656 18 . . . cord-007788-09t52zix 657 1 The the DT cord-007788-09t52zix 657 2 incidence incidence NN cord-007788-09t52zix 657 3 will will MD cord-007788-09t52zix 657 4 vary vary VB cord-007788-09t52zix 657 5 with with IN cord-007788-09t52zix 657 6 the the DT cord-007788-09t52zix 657 7 criteria criterion NNS cord-007788-09t52zix 657 8 used use VBN cord-007788-09t52zix 657 9 to to TO cord-007788-09t52zix 657 10 diagnose diagnose VB cord-007788-09t52zix 657 11 TAM TAM NNP cord-007788-09t52zix 657 12 . . . cord-007788-09t52zix 658 1 In in IN cord-007788-09t52zix 658 2 retrospective retrospective JJ cord-007788-09t52zix 658 3 data datum NNS cord-007788-09t52zix 658 4 , , , cord-007788-09t52zix 658 5 the the DT cord-007788-09t52zix 658 6 incidence incidence NN cord-007788-09t52zix 658 7 is be VBZ cord-007788-09t52zix 658 8 approximately approximately RB cord-007788-09t52zix 658 9 4 4 CD cord-007788-09t52zix 658 10 % % NN cord-007788-09t52zix 658 11 in in IN cord-007788-09t52zix 658 12 auto auto NN cord-007788-09t52zix 658 13 - - HYPH cord-007788-09t52zix 658 14 HSCT HSCT NNP cord-007788-09t52zix 658 15 , , , cord-007788-09t52zix 658 16 7 7 CD cord-007788-09t52zix 658 17 % % NN cord-007788-09t52zix 658 18 has have VBZ cord-007788-09t52zix 658 19 been be VBN cord-007788-09t52zix 658 20 reported report VBN cord-007788-09t52zix 658 21 in in IN cord-007788-09t52zix 658 22 allo allo NN cord-007788-09t52zix 658 23 - - HYPH cord-007788-09t52zix 658 24 HSCT HSCT NNP cord-007788-09t52zix 658 25 ( ( -LRB- cord-007788-09t52zix 658 26 Carreras Carreras NNP cord-007788-09t52zix 658 27 2012 2012 CD cord-007788-09t52zix 658 28 ) ) -RRB- cord-007788-09t52zix 658 29 , , , cord-007788-09t52zix 658 30 whereas whereas IN cord-007788-09t52zix 658 31 one one CD cord-007788-09t52zix 658 32 prospective prospective JJ cord-007788-09t52zix 658 33 study study NN cord-007788-09t52zix 658 34 has have VBZ cord-007788-09t52zix 658 35 shown show VBN cord-007788-09t52zix 658 36 an an DT cord-007788-09t52zix 658 37 incidence incidence NN cord-007788-09t52zix 658 38 close close JJ cord-007788-09t52zix 658 39 to to IN cord-007788-09t52zix 658 40 40 40 CD cord-007788-09t52zix 658 41 % % NN cord-007788-09t52zix 659 1 ( ( -LRB- cord-007788-09t52zix 659 2 Jodele Jodele NNP cord-007788-09t52zix 659 3 et et NNP cord-007788-09t52zix 659 4 al al NNP cord-007788-09t52zix 659 5 . . NNP cord-007788-09t52zix 659 6 2015 2015 CD cord-007788-09t52zix 659 7 ) ) -RRB- cord-007788-09t52zix 659 8 . . . cord-007788-09t52zix 660 1 Conditioning conditioning NN cord-007788-09t52zix 660 2 intensity intensity NN cord-007788-09t52zix 660 3 , , , cord-007788-09t52zix 660 4 myeloablative myeloablative NNP cord-007788-09t52zix 660 5 ( ( -LRB- cord-007788-09t52zix 660 6 MAC MAC NNP cord-007788-09t52zix 660 7 ) ) -RRB- cord-007788-09t52zix 660 8 versus versus IN cord-007788-09t52zix 660 9 reduced reduce VBN cord-007788-09t52zix 660 10 ( ( -LRB- cord-007788-09t52zix 660 11 RIC RIC NNP cord-007788-09t52zix 660 12 ) ) -RRB- cord-007788-09t52zix 660 13 , , , cord-007788-09t52zix 660 14 has have VBZ cord-007788-09t52zix 660 15 not not RB cord-007788-09t52zix 660 16 shown show VBN cord-007788-09t52zix 660 17 any any DT cord-007788-09t52zix 660 18 difference difference NN cord-007788-09t52zix 660 19 in in IN cord-007788-09t52zix 660 20 incidence incidence NN cord-007788-09t52zix 660 21 in in IN cord-007788-09t52zix 660 22 allo allo NN cord-007788-09t52zix 660 23 - - HYPH cord-007788-09t52zix 660 24 HSCT HSCT NNP cord-007788-09t52zix 660 25 . . . cord-007788-09t52zix 661 1 As as IN cord-007788-09t52zix 661 2 with with IN cord-007788-09t52zix 661 3 many many JJ cord-007788-09t52zix 661 4 early early JJ cord-007788-09t52zix 661 5 complications complication NNS cord-007788-09t52zix 661 6 in in IN cord-007788-09t52zix 661 7 HSCT HSCT NNP cord-007788-09t52zix 661 8 prompt prompt JJ cord-007788-09t52zix 661 9 recognition recognition NN cord-007788-09t52zix 661 10 of of IN cord-007788-09t52zix 661 11 early early JJ cord-007788-09t52zix 661 12 signs sign NNS cord-007788-09t52zix 661 13 and and CC cord-007788-09t52zix 661 14 symptoms symptom NNS cord-007788-09t52zix 661 15 with with IN cord-007788-09t52zix 661 16 early early JJ cord-007788-09t52zix 661 17 diagnosis diagnosis NN cord-007788-09t52zix 661 18 and and CC cord-007788-09t52zix 661 19 intervention intervention NN cord-007788-09t52zix 661 20 will will MD cord-007788-09t52zix 661 21 increase increase VB cord-007788-09t52zix 661 22 the the DT cord-007788-09t52zix 661 23 chances chance NNS cord-007788-09t52zix 661 24 of of IN cord-007788-09t52zix 661 25 a a DT cord-007788-09t52zix 661 26 positive positive JJ cord-007788-09t52zix 661 27 outcome outcome NN cord-007788-09t52zix 661 28 . . . cord-007788-09t52zix 662 1 Cases case NNS cord-007788-09t52zix 662 2 of of IN cord-007788-09t52zix 662 3 mild mild JJ cord-007788-09t52zix 662 4 TAM tam NN cord-007788-09t52zix 662 5 where where WRB cord-007788-09t52zix 662 6 calcineurin calcineurin NN cord-007788-09t52zix 662 7 inhibitor inhibitor NN cord-007788-09t52zix 662 8 ( ( -LRB- cord-007788-09t52zix 662 9 CNI CNI NNP cord-007788-09t52zix 662 10 ) ) -RRB- cord-007788-09t52zix 662 11 , , , cord-007788-09t52zix 662 12 e.g. e.g. RB cord-007788-09t52zix 662 13 cyclosporine cyclosporine NN cord-007788-09t52zix 662 14 , , , cord-007788-09t52zix 662 15 tacrolimus tacrolimus NN cord-007788-09t52zix 662 16 and and CC cord-007788-09t52zix 662 17 sirolimus sirolimus NNP cord-007788-09t52zix 662 18 , , , cord-007788-09t52zix 662 19 is be VBZ cord-007788-09t52zix 662 20 the the DT cord-007788-09t52zix 662 21 cause cause NN cord-007788-09t52zix 662 22 generally generally RB cord-007788-09t52zix 662 23 have have VBP cord-007788-09t52zix 662 24 a a DT cord-007788-09t52zix 662 25 good good JJ cord-007788-09t52zix 662 26 prognosis prognosis NN cord-007788-09t52zix 662 27 if if IN cord-007788-09t52zix 662 28 CNI CNI NNP cord-007788-09t52zix 662 29 can can MD cord-007788-09t52zix 662 30 be be VB cord-007788-09t52zix 662 31 discontinued discontinue VBN cord-007788-09t52zix 662 32 . . . cord-007788-09t52zix 663 1 If if IN cord-007788-09t52zix 663 2 TAM TAM NNP cord-007788-09t52zix 663 3 is be VBZ cord-007788-09t52zix 663 4 not not RB cord-007788-09t52zix 663 5 related relate VBN cord-007788-09t52zix 663 6 to to IN cord-007788-09t52zix 663 7 CNI CNI NNP cord-007788-09t52zix 663 8 treatment treatment NN cord-007788-09t52zix 663 9 , , , cord-007788-09t52zix 663 10 the the DT cord-007788-09t52zix 663 11 prognosis prognosis NN cord-007788-09t52zix 663 12 is be VBZ cord-007788-09t52zix 663 13 worse bad JJR cord-007788-09t52zix 663 14 due due IN cord-007788-09t52zix 663 15 to to IN cord-007788-09t52zix 663 16 lack lack NN cord-007788-09t52zix 663 17 of of IN cord-007788-09t52zix 663 18 effective effective JJ cord-007788-09t52zix 663 19 treatment treatment NN cord-007788-09t52zix 663 20 options option NNS cord-007788-09t52zix 663 21 . . . cord-007788-09t52zix 664 1 Exact exact JJ cord-007788-09t52zix 664 2 figures figure NNS cord-007788-09t52zix 664 3 for for IN cord-007788-09t52zix 664 4 mortality mortality NN cord-007788-09t52zix 664 5 rate rate NN cord-007788-09t52zix 664 6 are be VBP cord-007788-09t52zix 664 7 difficult difficult JJ cord-007788-09t52zix 664 8 to to TO cord-007788-09t52zix 664 9 establish establish VB cord-007788-09t52zix 664 10 , , , cord-007788-09t52zix 664 11 but but CC cord-007788-09t52zix 664 12 in in IN cord-007788-09t52zix 664 13 patients patient NNS cord-007788-09t52zix 664 14 with with IN cord-007788-09t52zix 664 15 TAM TAM NNP cord-007788-09t52zix 664 16 and and CC cord-007788-09t52zix 664 17 multi multi JJ cord-007788-09t52zix 664 18 - - JJ cord-007788-09t52zix 664 19 organ organ JJ cord-007788-09t52zix 664 20 involvement involvement NN cord-007788-09t52zix 664 21 , , , cord-007788-09t52zix 664 22 the the DT cord-007788-09t52zix 664 23 mortality mortality NN cord-007788-09t52zix 664 24 is be VBZ cord-007788-09t52zix 664 25 as as RB cord-007788-09t52zix 664 26 high high JJ cord-007788-09t52zix 664 27 as as IN cord-007788-09t52zix 664 28 > > XX cord-007788-09t52zix 664 29 90 90 CD cord-007788-09t52zix 664 30 % % NN cord-007788-09t52zix 664 31 . . . cord-007788-09t52zix 665 1 Patients patient NNS cord-007788-09t52zix 665 2 surviving survive VBG cord-007788-09t52zix 665 3 TAM TAM NNP cord-007788-09t52zix 665 4 are be VBP cord-007788-09t52zix 665 5 as as IN cord-007788-09t52zix 665 6 a a DT cord-007788-09t52zix 665 7 consequence consequence NN cord-007788-09t52zix 665 8 at at IN cord-007788-09t52zix 665 9 greater great JJR cord-007788-09t52zix 665 10 risk risk NN cord-007788-09t52zix 665 11 for for IN cord-007788-09t52zix 665 12 chronic chronic JJ cord-007788-09t52zix 665 13 kidney kidney NN cord-007788-09t52zix 665 14 disease disease NN cord-007788-09t52zix 665 15 ( ( -LRB- cord-007788-09t52zix 665 16 CKD CKD NNP cord-007788-09t52zix 665 17 ) ) -RRB- cord-007788-09t52zix 665 18 and and CC cord-007788-09t52zix 665 19 hypertension hypertension NN cord-007788-09t52zix 665 20 later later RB cord-007788-09t52zix 665 21 on on RB cord-007788-09t52zix 665 22 . . . cord-007788-09t52zix 666 1 Use use NN cord-007788-09t52zix 666 2 of of IN cord-007788-09t52zix 666 3 total total JJ cord-007788-09t52zix 666 4 body body NN cord-007788-09t52zix 666 5 irradiation irradiation NN cord-007788-09t52zix 666 6 ( ( -LRB- cord-007788-09t52zix 666 7 TBI TBI NNP cord-007788-09t52zix 666 8 ) ) -RRB- cord-007788-09t52zix 666 9 in in IN cord-007788-09t52zix 666 10 conditioning conditioning NN cord-007788-09t52zix 666 11 treatment treatment NN cord-007788-09t52zix 666 12 , , , cord-007788-09t52zix 666 13 CNI CNI NNP cord-007788-09t52zix 666 14 , , , cord-007788-09t52zix 666 15 graft graft NN cord-007788-09t52zix 666 16 versus versus IN cord-007788-09t52zix 666 17 host host NN cord-007788-09t52zix 666 18 disease disease NN cord-007788-09t52zix 666 19 ( ( -LRB- cord-007788-09t52zix 666 20 GvHD GvHD NNP cord-007788-09t52zix 666 21 ) ) -RRB- cord-007788-09t52zix 666 22 , , , cord-007788-09t52zix 666 23 infections infection NNS cord-007788-09t52zix 666 24 ( ( -LRB- cord-007788-09t52zix 666 25 e.g. e.g. IN cord-007788-09t52zix 666 26 cytomegalovirus cytomegalovirus NNP cord-007788-09t52zix 666 27 ( ( -LRB- cord-007788-09t52zix 666 28 CMV CMV NNP cord-007788-09t52zix 666 29 ) ) -RRB- cord-007788-09t52zix 666 30 and and CC cord-007788-09t52zix 666 31 fungal fungal JJ cord-007788-09t52zix 666 32 infections infection NNS cord-007788-09t52zix 666 33 ) ) -RRB- cord-007788-09t52zix 666 34 and and CC cord-007788-09t52zix 666 35 unrelated unrelated JJ cord-007788-09t52zix 666 36 donor donor NN cord-007788-09t52zix 666 37 transplant transplant NN cord-007788-09t52zix 666 38 ( ( -LRB- cord-007788-09t52zix 666 39 in in IN cord-007788-09t52zix 666 40 particular particular JJ cord-007788-09t52zix 666 41 if if IN cord-007788-09t52zix 666 42 mismatched mismatched JJ cord-007788-09t52zix 666 43 ) ) -RRB- cord-007788-09t52zix 666 44 are be VBP cord-007788-09t52zix 666 45 all all DT cord-007788-09t52zix 666 46 considered consider VBN cord-007788-09t52zix 666 47 risk risk NN cord-007788-09t52zix 666 48 factors factor NNS cord-007788-09t52zix 666 49 or or CC cord-007788-09t52zix 666 50 triggers trigger NNS cord-007788-09t52zix 666 51 for for IN cord-007788-09t52zix 666 52 TAM TAM NNP cord-007788-09t52zix 666 53 , , , cord-007788-09t52zix 666 54 although although IN cord-007788-09t52zix 666 55 reported report VBN cord-007788-09t52zix 666 56 data datum NNS cord-007788-09t52zix 666 57 is be VBZ cord-007788-09t52zix 666 58 conflicting conflict VBG cord-007788-09t52zix 666 59 ( ( -LRB- cord-007788-09t52zix 666 60 Nadir Nadir NNP cord-007788-09t52zix 666 61 and and CC cord-007788-09t52zix 666 62 Brenner Brenner NNP cord-007788-09t52zix 666 63 2012 2012 CD cord-007788-09t52zix 666 64 ; ; : cord-007788-09t52zix 666 65 Rosenthal Rosenthal NNP cord-007788-09t52zix 666 66 2016 2016 CD cord-007788-09t52zix 666 67 ) ) -RRB- cord-007788-09t52zix 666 68 . . . cord-007788-09t52zix 667 1 TAM TAM NNP cord-007788-09t52zix 667 2 usually usually RB cord-007788-09t52zix 667 3 has have VBZ cord-007788-09t52zix 667 4 an an DT cord-007788-09t52zix 667 5 onset onset NN cord-007788-09t52zix 667 6 between between IN cord-007788-09t52zix 667 7 1 1 CD cord-007788-09t52zix 667 8 and and CC cord-007788-09t52zix 667 9 2 2 CD cord-007788-09t52zix 667 10 months month NNS cord-007788-09t52zix 667 11 after after IN cord-007788-09t52zix 667 12 HSCT HSCT NNP cord-007788-09t52zix 667 13 but but CC cord-007788-09t52zix 667 14 can can MD cord-007788-09t52zix 667 15 be be VB cord-007788-09t52zix 667 16 seen see VBN cord-007788-09t52zix 667 17 both both DT cord-007788-09t52zix 667 18 earlier early RBR cord-007788-09t52zix 667 19 and and CC cord-007788-09t52zix 667 20 later later RB cord-007788-09t52zix 667 21 . . . cord-007788-09t52zix 668 1 Several several JJ cord-007788-09t52zix 668 2 slightly slightly RB cord-007788-09t52zix 668 3 different different JJ cord-007788-09t52zix 668 4 criteria criterion NNS cord-007788-09t52zix 668 5 for for IN cord-007788-09t52zix 668 6 diagnosis diagnosis NN cord-007788-09t52zix 668 7 of of IN cord-007788-09t52zix 668 8 TAM TAM NNP cord-007788-09t52zix 668 9 are be VBP cord-007788-09t52zix 668 10 being be VBG cord-007788-09t52zix 668 11 used use VBN cord-007788-09t52zix 669 1 ( ( -LRB- cord-007788-09t52zix 669 2 Sahin Sahin NNP cord-007788-09t52zix 669 3 et et NNP cord-007788-09t52zix 669 4 al al NNP cord-007788-09t52zix 669 5 . . . cord-007788-09t52zix 669 6 2016 2016 CD cord-007788-09t52zix 669 7 ) ) -RRB- cord-007788-09t52zix 669 8 . . . cord-007788-09t52zix 670 1 See see VB cord-007788-09t52zix 670 2 adapted adapt VBN cord-007788-09t52zix 670 3 Table Table NNP cord-007788-09t52zix 670 4 9 9 CD cord-007788-09t52zix 670 5 .10 .10 CD cord-007788-09t52zix 670 6 . . . cord-007788-09t52zix 671 1 The the DT cord-007788-09t52zix 671 2 diagnosis diagnosis NN cord-007788-09t52zix 671 3 is be VBZ cord-007788-09t52zix 671 4 difficult difficult JJ cord-007788-09t52zix 671 5 but but CC cord-007788-09t52zix 671 6 can can MD cord-007788-09t52zix 671 7 be be VB cord-007788-09t52zix 671 8 confirmed confirm VBN cord-007788-09t52zix 671 9 with with IN cord-007788-09t52zix 671 10 a a DT cord-007788-09t52zix 671 11 biopsy biopsy JJ cord-007788-09t52zix 671 12 tissue tissue NN cord-007788-09t52zix 671 13 sample sample NN cord-007788-09t52zix 671 14 although although IN cord-007788-09t52zix 671 15 this this DT cord-007788-09t52zix 671 16 invasive invasive JJ cord-007788-09t52zix 671 17 test test NN cord-007788-09t52zix 671 18 may may MD cord-007788-09t52zix 671 19 not not RB cord-007788-09t52zix 671 20 always always RB cord-007788-09t52zix 671 21 be be VB cord-007788-09t52zix 671 22 an an DT cord-007788-09t52zix 671 23 option option NN cord-007788-09t52zix 671 24 for for IN cord-007788-09t52zix 671 25 the the DT cord-007788-09t52zix 671 26 seriously seriously RB cord-007788-09t52zix 671 27 ill ill JJ cord-007788-09t52zix 671 28 HSCT HSCT NNP cord-007788-09t52zix 671 29 recipient recipient NN cord-007788-09t52zix 671 30 . . . cord-007788-09t52zix 672 1 TAM TAM NNP cord-007788-09t52zix 672 2 has have VBZ cord-007788-09t52zix 672 3 clinical clinical JJ cord-007788-09t52zix 672 4 similarities similarity NNS cord-007788-09t52zix 672 5 with with IN cord-007788-09t52zix 672 6 idiopathic idiopathic JJ cord-007788-09t52zix 672 7 thrombotic thrombotic JJ cord-007788-09t52zix 672 8 thrombocytopenic thrombocytopenic JJ cord-007788-09t52zix 672 9 purpura purpura NN cord-007788-09t52zix 672 10 ( ( -LRB- cord-007788-09t52zix 672 11 TTP TTP NNP cord-007788-09t52zix 672 12 ) ) -RRB- cord-007788-09t52zix 672 13 , , , cord-007788-09t52zix 672 14 and and CC cord-007788-09t52zix 672 15 laboratory laboratory NN cord-007788-09t52zix 672 16 testing testing NN cord-007788-09t52zix 672 17 for for IN cord-007788-09t52zix 672 18 the the DT cord-007788-09t52zix 672 19 von von NNP cord-007788-09t52zix 672 20 Willebrand Willebrand NNP cord-007788-09t52zix 672 21 factor factor NN cord-007788-09t52zix 672 22 regulator regulator NN cord-007788-09t52zix 673 1 ADAMTS13 ADAMTS13 NNP cord-007788-09t52zix 673 2 can can MD cord-007788-09t52zix 673 3 be be VB cord-007788-09t52zix 673 4 performed perform VBN cord-007788-09t52zix 673 5 to to TO cord-007788-09t52zix 673 6 support support VB cord-007788-09t52zix 673 7 the the DT cord-007788-09t52zix 673 8 diagnosis diagnosis NN cord-007788-09t52zix 673 9 . . . cord-007788-09t52zix 674 1 In in IN cord-007788-09t52zix 674 2 classical classical JJ cord-007788-09t52zix 674 3 TTP TTP NNP cord-007788-09t52zix 674 4 , , , cord-007788-09t52zix 674 5 there there EX cord-007788-09t52zix 674 6 is be VBZ cord-007788-09t52zix 674 7 a a DT cord-007788-09t52zix 674 8 severe severe JJ cord-007788-09t52zix 674 9 deficiency deficiency NN cord-007788-09t52zix 674 10 , , , cord-007788-09t52zix 674 11 while while IN cord-007788-09t52zix 674 12 no no DT cord-007788-09t52zix 674 13 significant significant JJ cord-007788-09t52zix 674 14 decrease decrease NN cord-007788-09t52zix 674 15 of of IN cord-007788-09t52zix 674 16 ADAMTS13 ADAMTS13 NNP cord-007788-09t52zix 674 17 is be VBZ cord-007788-09t52zix 674 18 seen see VBN cord-007788-09t52zix 674 19 in in IN cord-007788-09t52zix 674 20 TAM TAM NNP cord-007788-09t52zix 674 21 ( ( -LRB- cord-007788-09t52zix 674 22 Graf Graf NNP cord-007788-09t52zix 674 23 and and CC cord-007788-09t52zix 674 24 Stern Stern NNP cord-007788-09t52zix 674 25 2012 2012 CD cord-007788-09t52zix 674 26 ) ) -RRB- cord-007788-09t52zix 674 27 . . . cord-007788-09t52zix 675 1 Renal renal JJ cord-007788-09t52zix 675 2 TAM TAM NNP cord-007788-09t52zix 675 3 should should MD cord-007788-09t52zix 675 4 be be VB cord-007788-09t52zix 675 5 suspected suspect VBN cord-007788-09t52zix 675 6 if if IN cord-007788-09t52zix 675 7 the the DT cord-007788-09t52zix 675 8 patient patient NN cord-007788-09t52zix 675 9 requires require VBZ cord-007788-09t52zix 675 10 higher high JJR cord-007788-09t52zix 675 11 doses dose NNS cord-007788-09t52zix 675 12 of of IN cord-007788-09t52zix 675 13 antihypertensives antihypertensive NNS cord-007788-09t52zix 675 14 than than IN cord-007788-09t52zix 675 15 would would MD cord-007788-09t52zix 675 16 be be VB cord-007788-09t52zix 675 17 expected expect VBN cord-007788-09t52zix 675 18 considering consider VBG cord-007788-09t52zix 675 19 the the DT cord-007788-09t52zix 675 20 situation situation NN cord-007788-09t52zix 675 21 and and CC cord-007788-09t52zix 675 22 concomitant concomitant JJ cord-007788-09t52zix 675 23 and/or and/or CC cord-007788-09t52zix 675 24 nephrotoxic nephrotoxic NNP cord-007788-09t52zix 675 25 medication medication NNP cord-007788-09t52zix 675 26 . . . cord-007788-09t52zix 676 1 Example example NN cord-007788-09t52zix 676 2 of of IN cord-007788-09t52zix 676 3 a a DT cord-007788-09t52zix 676 4 differential differential JJ cord-007788-09t52zix 676 5 diagnosis diagnosis NN cord-007788-09t52zix 676 6 is be VBZ cord-007788-09t52zix 676 7 virusrelated virusrelate VBN cord-007788-09t52zix 676 8 nephropathy nephropathy NN cord-007788-09t52zix 676 9 . . . cord-007788-09t52zix 677 1 Symptoms symptom NNS cord-007788-09t52zix 677 2 such such JJ cord-007788-09t52zix 677 3 as as IN cord-007788-09t52zix 677 4 tachycardia tachycardia NN cord-007788-09t52zix 677 5 , , , cord-007788-09t52zix 677 6 chest chest NN cord-007788-09t52zix 677 7 pain pain NN cord-007788-09t52zix 677 8 and and CC cord-007788-09t52zix 677 9 hypoxemia hypoxemia NN cord-007788-09t52zix 677 10 should should MD cord-007788-09t52zix 677 11 lead lead VB cord-007788-09t52zix 677 12 to to IN cord-007788-09t52zix 677 13 suspicion suspicion NN cord-007788-09t52zix 677 14 of of IN cord-007788-09t52zix 677 15 lung lung NN cord-007788-09t52zix 677 16 involvement involvement NN cord-007788-09t52zix 677 17 and and CC cord-007788-09t52zix 677 18 pulmonary pulmonary JJ cord-007788-09t52zix 677 19 hypertension hypertension NN cord-007788-09t52zix 677 20 . . . cord-007788-09t52zix 678 1 The the DT cord-007788-09t52zix 678 2 diagnosis diagnosis NN cord-007788-09t52zix 678 3 can can MD cord-007788-09t52zix 678 4 be be VB cord-007788-09t52zix 678 5 supported support VBN cord-007788-09t52zix 678 6 by by IN cord-007788-09t52zix 678 7 findings finding NNS cord-007788-09t52zix 678 8 of of IN cord-007788-09t52zix 678 9 cardiomegaly cardiomegaly NN cord-007788-09t52zix 678 10 on on IN cord-007788-09t52zix 678 11 chest chest NN cord-007788-09t52zix 678 12 X x NN cord-007788-09t52zix 678 13 - - NN cord-007788-09t52zix 678 14 ray ray NN cord-007788-09t52zix 678 15 , , , cord-007788-09t52zix 678 16 pericardial pericardial JJ cord-007788-09t52zix 678 17 effusion effusion NN cord-007788-09t52zix 678 18 on on IN cord-007788-09t52zix 678 19 transthoracic transthoracic NNP cord-007788-09t52zix 678 20 echocardiography echocardiography NN cord-007788-09t52zix 678 21 and and CC cord-007788-09t52zix 678 22 blood blood NN cord-007788-09t52zix 678 23 tests test NNS cord-007788-09t52zix 678 24 . . . cord-007788-09t52zix 679 1 Intestinal intestinal JJ cord-007788-09t52zix 679 2 TAM TAM NNP cord-007788-09t52zix 679 3 presents present VBZ cord-007788-09t52zix 679 4 with with IN cord-007788-09t52zix 679 5 the the DT cord-007788-09t52zix 679 6 same same JJ cord-007788-09t52zix 679 7 symptoms symptom NNS cord-007788-09t52zix 679 8 as as IN cord-007788-09t52zix 679 9 acute acute JJ cord-007788-09t52zix 679 10 GvHD GvHD NNP cord-007788-09t52zix 679 11 ( ( -LRB- cord-007788-09t52zix 679 12 aGvHD agvhd NN cord-007788-09t52zix 679 13 ) ) -RRB- cord-007788-09t52zix 679 14 , , , cord-007788-09t52zix 679 15 abdominal abdominal JJ cord-007788-09t52zix 679 16 pain pain NN cord-007788-09t52zix 679 17 , , , cord-007788-09t52zix 679 18 diarrhoea diarrhoea NN cord-007788-09t52zix 679 19 , , , cord-007788-09t52zix 679 20 vomiting vomiting NN cord-007788-09t52zix 679 21 and and CC cord-007788-09t52zix 679 22 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 679 23 bleeding bleeding NN cord-007788-09t52zix 679 24 . . . cord-007788-09t52zix 680 1 The the DT cord-007788-09t52zix 680 2 symptoms symptom NNS cord-007788-09t52zix 680 3 can can MD cord-007788-09t52zix 680 4 also also RB cord-007788-09t52zix 680 5 be be VB cord-007788-09t52zix 680 6 mistaken mistake VBN cord-007788-09t52zix 680 7 for for IN cord-007788-09t52zix 680 8 infectious infectious JJ cord-007788-09t52zix 680 9 colitis colitis NN cord-007788-09t52zix 680 10 , , , cord-007788-09t52zix 680 11 but but CC cord-007788-09t52zix 680 12 in in IN cord-007788-09t52zix 680 13 TAM TAM NNP cord-007788-09t52zix 680 14 the the DT cord-007788-09t52zix 680 15 cause cause NN cord-007788-09t52zix 680 16 of of IN cord-007788-09t52zix 680 17 the the DT cord-007788-09t52zix 680 18 bleeding bleeding NN cord-007788-09t52zix 680 19 is be VBZ cord-007788-09t52zix 680 20 ischemia ischemia NN cord-007788-09t52zix 680 21 in in IN cord-007788-09t52zix 680 22 the the DT cord-007788-09t52zix 680 23 bowels bowel NNS cord-007788-09t52zix 680 24 due due IN cord-007788-09t52zix 680 25 to to IN cord-007788-09t52zix 680 26 the the DT cord-007788-09t52zix 680 27 microangiopathy microangiopathy NN cord-007788-09t52zix 680 28 . . . cord-007788-09t52zix 681 1 In in IN cord-007788-09t52zix 681 2 addition addition NN cord-007788-09t52zix 681 3 to to IN cord-007788-09t52zix 681 4 the the DT cord-007788-09t52zix 681 5 general general JJ cord-007788-09t52zix 681 6 diagnostic diagnostic JJ cord-007788-09t52zix 681 7 criteria criterion NNS cord-007788-09t52zix 681 8 , , , cord-007788-09t52zix 681 9 specific specific JJ cord-007788-09t52zix 681 10 criteria criterion NNS cord-007788-09t52zix 681 11 for for IN cord-007788-09t52zix 681 12 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 681 13 TAM TAM NNP cord-007788-09t52zix 681 14 have have VBP cord-007788-09t52zix 681 15 been be VBN cord-007788-09t52zix 681 16 proposed propose VBN cord-007788-09t52zix 681 17 . . . cord-007788-09t52zix 682 1 Besides besides IN cord-007788-09t52zix 682 2 the the DT cord-007788-09t52zix 682 3 clinical clinical JJ cord-007788-09t52zix 682 4 symptoms symptom NNS cord-007788-09t52zix 682 5 , , , cord-007788-09t52zix 682 6 X x NN cord-007788-09t52zix 682 7 - - NN cord-007788-09t52zix 682 8 ray ray NN cord-007788-09t52zix 682 9 findings finding NNS cord-007788-09t52zix 682 10 with with IN cord-007788-09t52zix 682 11 signs sign NNS cord-007788-09t52zix 682 12 of of IN cord-007788-09t52zix 682 13 ileus ileus NN cord-007788-09t52zix 682 14 and and CC cord-007788-09t52zix 682 15 thick thick JJ cord-007788-09t52zix 682 16 mucosal mucosal JJ cord-007788-09t52zix 682 17 wall wall NN cord-007788-09t52zix 682 18 and and CC cord-007788-09t52zix 682 19 endoscopy endoscopy NN cord-007788-09t52zix 682 20 with with IN cord-007788-09t52zix 682 21 mucosal mucosal JJ cord-007788-09t52zix 682 22 erosions erosion NNS cord-007788-09t52zix 682 23 and and CC cord-007788-09t52zix 682 24 haemorrhages haemorrhage NNS cord-007788-09t52zix 682 25 are be VBP cord-007788-09t52zix 682 26 included include VBN cord-007788-09t52zix 682 27 in in IN cord-007788-09t52zix 682 28 the the DT cord-007788-09t52zix 682 29 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 682 30 TAM TAM NNP cord-007788-09t52zix 682 31 diagnostic diagnostic JJ cord-007788-09t52zix 682 32 criteria criterion NNS cord-007788-09t52zix 682 33 , , , cord-007788-09t52zix 682 34 but but CC cord-007788-09t52zix 682 35 the the DT cord-007788-09t52zix 682 36 only only JJ cord-007788-09t52zix 682 37 definite definite JJ cord-007788-09t52zix 682 38 diagnostic diagnostic JJ cord-007788-09t52zix 682 39 test test NN cord-007788-09t52zix 682 40 is be VBZ cord-007788-09t52zix 682 41 a a DT cord-007788-09t52zix 682 42 biopsy biopsy JJ cord-007788-09t52zix 682 43 tissue tissue NN cord-007788-09t52zix 682 44 sample sample NN cord-007788-09t52zix 682 45 . . . cord-007788-09t52zix 683 1 As as IN cord-007788-09t52zix 683 2 a a DT cord-007788-09t52zix 683 3 result result NN cord-007788-09t52zix 683 4 of of IN cord-007788-09t52zix 683 5 generalised generalised JJ cord-007788-09t52zix 683 6 vascular vascular JJ cord-007788-09t52zix 683 7 injury injury NN cord-007788-09t52zix 683 8 in in IN cord-007788-09t52zix 683 9 TAM TAM NNP cord-007788-09t52zix 683 10 , , , cord-007788-09t52zix 683 11 polyserositis polyserositis NN cord-007788-09t52zix 683 12 with with IN cord-007788-09t52zix 683 13 pericardial pericardial JJ cord-007788-09t52zix 683 14 and and CC cord-007788-09t52zix 683 15 pleural pleural JJ cord-007788-09t52zix 683 16 effusion effusion NN cord-007788-09t52zix 683 17 and and CC cord-007788-09t52zix 683 18 ascites ascite NNS cord-007788-09t52zix 683 19 can can MD cord-007788-09t52zix 683 20 occur occur VB cord-007788-09t52zix 683 21 . . . cord-007788-09t52zix 684 1 It -PRON- PRP cord-007788-09t52zix 684 2 can can MD cord-007788-09t52zix 684 3 easily easily RB cord-007788-09t52zix 684 4 be be VB cord-007788-09t52zix 684 5 mistaken mistake VBN cord-007788-09t52zix 684 6 for for IN cord-007788-09t52zix 684 7 GvHD gvhd NN cord-007788-09t52zix 684 8 , , , cord-007788-09t52zix 684 9 but but CC cord-007788-09t52zix 684 10 where where WRB cord-007788-09t52zix 684 11 GvHD GvHD VBG cord-007788-09t52zix 684 12 more more RBR cord-007788-09t52zix 684 13 seldom seldom RB cord-007788-09t52zix 684 14 is be VBZ cord-007788-09t52zix 684 15 associated associate VBN cord-007788-09t52zix 684 16 with with IN cord-007788-09t52zix 684 17 microangiopathic microangiopathic JJ cord-007788-09t52zix 684 18 anaemia anaemia NN cord-007788-09t52zix 684 19 , , , cord-007788-09t52zix 684 20 proteinuria proteinuria NN cord-007788-09t52zix 684 21 and and CC cord-007788-09t52zix 684 22 hypertension hypertension NN cord-007788-09t52zix 684 23 , , , cord-007788-09t52zix 684 24 these these DT cord-007788-09t52zix 684 25 symptoms symptom NNS cord-007788-09t52zix 684 26 are be VBP cord-007788-09t52zix 684 27 common common JJ cord-007788-09t52zix 684 28 in in IN cord-007788-09t52zix 684 29 TAM TAM NNP cord-007788-09t52zix 684 30 . . . cord-007788-09t52zix 685 1 No no DT cord-007788-09t52zix 685 2 specific specific JJ cord-007788-09t52zix 685 3 prophylaxis prophylaxis NN cord-007788-09t52zix 685 4 exists exist VBZ cord-007788-09t52zix 685 5 , , , cord-007788-09t52zix 685 6 so so RB cord-007788-09t52zix 685 7 vigilant vigilant JJ cord-007788-09t52zix 685 8 monitoring monitoring NN cord-007788-09t52zix 685 9 of of IN cord-007788-09t52zix 685 10 clinical clinical JJ cord-007788-09t52zix 685 11 signs sign NNS cord-007788-09t52zix 685 12 and and CC cord-007788-09t52zix 685 13 symptoms symptom NNS cord-007788-09t52zix 685 14 is be VBZ cord-007788-09t52zix 685 15 neces nece NNS cord-007788-09t52zix 685 16 - - HYPH cord-007788-09t52zix 685 17 sary sary JJ cord-007788-09t52zix 685 18 . . . cord-007788-09t52zix 686 1 CNI CNI NNP cord-007788-09t52zix 686 2 concentration concentration NN cord-007788-09t52zix 686 3 in in IN cord-007788-09t52zix 686 4 blood blood NN cord-007788-09t52zix 686 5 , , , cord-007788-09t52zix 686 6 lactate lactate NN cord-007788-09t52zix 686 7 dehydrogenase dehydrogenase NN cord-007788-09t52zix 686 8 ( ( -LRB- cord-007788-09t52zix 686 9 LD LD NNP cord-007788-09t52zix 686 10 or or CC cord-007788-09t52zix 686 11 LDH LDH NNP cord-007788-09t52zix 686 12 ) ) -RRB- cord-007788-09t52zix 686 13 and and CC cord-007788-09t52zix 686 14 serum serum NN cord-007788-09t52zix 686 15 creatinine creatinine NN cord-007788-09t52zix 686 16 should should MD cord-007788-09t52zix 686 17 be be VB cord-007788-09t52zix 686 18 closely closely RB cord-007788-09t52zix 686 19 followed follow VBN cord-007788-09t52zix 686 20 , , , cord-007788-09t52zix 686 21 i.e. i.e. FW cord-007788-09t52zix 686 22 two two CD cord-007788-09t52zix 686 23 to to TO cord-007788-09t52zix 686 24 three three CD cord-007788-09t52zix 686 25 times time NNS cord-007788-09t52zix 686 26 / / SYM cord-007788-09t52zix 686 27 week week NN cord-007788-09t52zix 686 28 , , , cord-007788-09t52zix 686 29 with with IN cord-007788-09t52zix 686 30 laboratory laboratory NN cord-007788-09t52zix 686 31 testing testing NN cord-007788-09t52zix 686 32 . . . cord-007788-09t52zix 687 1 Additional additional JJ cord-007788-09t52zix 687 2 blood blood NN cord-007788-09t52zix 687 3 tests test NNS cord-007788-09t52zix 687 4 with with IN cord-007788-09t52zix 687 5 peripheral peripheral JJ cord-007788-09t52zix 687 6 blood blood NN cord-007788-09t52zix 687 7 smear smear NN cord-007788-09t52zix 687 8 , , , cord-007788-09t52zix 687 9 haptoglobin haptoglobin NN cord-007788-09t52zix 687 10 and and CC cord-007788-09t52zix 687 11 direct direct JJ cord-007788-09t52zix 687 12 and and CC cord-007788-09t52zix 687 13 indirect indirect JJ cord-007788-09t52zix 687 14 antiglobulin antiglobulin NN cord-007788-09t52zix 687 15 tests test NNS cord-007788-09t52zix 687 16 ( ( -LRB- cord-007788-09t52zix 687 17 DAT DAT NNP cord-007788-09t52zix 687 18 and and CC cord-007788-09t52zix 687 19 IAT IAT NNP cord-007788-09t52zix 687 20 ) ) -RRB- cord-007788-09t52zix 687 21 should should MD cord-007788-09t52zix 687 22 be be VB cord-007788-09t52zix 687 23 performed perform VBN cord-007788-09t52zix 687 24 if if IN cord-007788-09t52zix 687 25 an an DT cord-007788-09t52zix 687 26 increase increase NN cord-007788-09t52zix 687 27 is be VBZ cord-007788-09t52zix 687 28 seen see VBN cord-007788-09t52zix 687 29 in in IN cord-007788-09t52zix 687 30 CNI CNI NNP cord-007788-09t52zix 687 31 , , , cord-007788-09t52zix 687 32 LD LD NNP cord-007788-09t52zix 687 33 and and CC cord-007788-09t52zix 687 34 creatinine creatinine NN cord-007788-09t52zix 687 35 levels level NNS cord-007788-09t52zix 687 36 . . . cord-007788-09t52zix 688 1 There there EX cord-007788-09t52zix 688 2 is be VBZ cord-007788-09t52zix 688 3 currently currently RB cord-007788-09t52zix 688 4 no no DT cord-007788-09t52zix 688 5 established establish VBN cord-007788-09t52zix 688 6 treatment treatment NN cord-007788-09t52zix 688 7 for for IN cord-007788-09t52zix 688 8 TMA TMA NNP cord-007788-09t52zix 688 9 but but CC cord-007788-09t52zix 688 10 supportive supportive JJ cord-007788-09t52zix 688 11 measures measure NNS cord-007788-09t52zix 688 12 should should MD cord-007788-09t52zix 688 13 always always RB cord-007788-09t52zix 688 14 be be VB cord-007788-09t52zix 688 15 taken take VBN cord-007788-09t52zix 688 16 . . . cord-007788-09t52zix 689 1 Traditionally traditionally RB cord-007788-09t52zix 689 2 the the DT cord-007788-09t52zix 689 3 first first JJ cord-007788-09t52zix 689 4 step step NN cord-007788-09t52zix 689 5 is be VBZ cord-007788-09t52zix 689 6 to to TO cord-007788-09t52zix 689 7 discontinue discontinue VB cord-007788-09t52zix 689 8 CNI CNI NNP cord-007788-09t52zix 689 9 , , , cord-007788-09t52zix 689 10 despite despite IN cord-007788-09t52zix 689 11 paucity paucity NN cord-007788-09t52zix 689 12 of of IN cord-007788-09t52zix 689 13 evidence evidence NN cord-007788-09t52zix 689 14 for for IN cord-007788-09t52zix 689 15 this this DT cord-007788-09t52zix 689 16 action action NN cord-007788-09t52zix 689 17 . . . cord-007788-09t52zix 690 1 It -PRON- PRP cord-007788-09t52zix 690 2 is be VBZ cord-007788-09t52zix 690 3 also also RB cord-007788-09t52zix 690 4 important important JJ cord-007788-09t52zix 690 5 to to TO cord-007788-09t52zix 690 6 treat treat VB cord-007788-09t52zix 690 7 infections infection NNS cord-007788-09t52zix 690 8 , , , cord-007788-09t52zix 690 9 GvHD GvHD NNP cord-007788-09t52zix 690 10 and and CC cord-007788-09t52zix 690 11 Jodele Jodele NNP cord-007788-09t52zix 690 12 et et NNP cord-007788-09t52zix 690 13 al al NNP cord-007788-09t52zix 690 14 . . . cord-007788-09t52zix 691 1 ( ( -LRB- cord-007788-09t52zix 691 2 2015 2015 CD cord-007788-09t52zix 691 3 ) ) -RRB- cord-007788-09t52zix 691 4 hypertension hypertension NN cord-007788-09t52zix 691 5 . . . cord-007788-09t52zix 692 1 Changing change VBG cord-007788-09t52zix 692 2 to to IN cord-007788-09t52zix 692 3 other other JJ cord-007788-09t52zix 692 4 GvHD gvhd NN cord-007788-09t52zix 692 5 prophylaxis prophylaxis NN cord-007788-09t52zix 692 6 and and CC cord-007788-09t52zix 692 7 use use NN cord-007788-09t52zix 692 8 of of IN cord-007788-09t52zix 692 9 antimicrobial antimicrobial JJ cord-007788-09t52zix 692 10 drugs drug NNS cord-007788-09t52zix 692 11 should should MD cord-007788-09t52zix 692 12 be be VB cord-007788-09t52zix 692 13 based base VBN cord-007788-09t52zix 692 14 on on IN cord-007788-09t52zix 692 15 a a DT cord-007788-09t52zix 692 16 risk risk NN cord-007788-09t52zix 692 17 - - HYPH cord-007788-09t52zix 692 18 benefit benefit NN cord-007788-09t52zix 692 19 assessment assessment NN cord-007788-09t52zix 692 20 where where WRB cord-007788-09t52zix 692 21 , , , cord-007788-09t52zix 692 22 for for IN cord-007788-09t52zix 692 23 example example NN cord-007788-09t52zix 692 24 , , , cord-007788-09t52zix 692 25 nephrotoxicity nephrotoxicity NNP cord-007788-09t52zix 692 26 is be VBZ cord-007788-09t52zix 692 27 considered consider VBN cord-007788-09t52zix 692 28 . . . cord-007788-09t52zix 693 1 Administration administration NN cord-007788-09t52zix 693 2 of of IN cord-007788-09t52zix 693 3 diuretics diuretic NNS cord-007788-09t52zix 693 4 may may MD cord-007788-09t52zix 693 5 be be VB cord-007788-09t52zix 693 6 necessary necessary JJ cord-007788-09t52zix 693 7 to to TO cord-007788-09t52zix 693 8 treat treat VB cord-007788-09t52zix 693 9 fluid fluid NN cord-007788-09t52zix 693 10 and and CC cord-007788-09t52zix 693 11 sodium sodium NN cord-007788-09t52zix 693 12 retention retention NN cord-007788-09t52zix 693 13 due due JJ cord-007788-09t52zix 693 14 to to IN cord-007788-09t52zix 693 15 steroid steroid NN cord-007788-09t52zix 693 16 treatment treatment NN cord-007788-09t52zix 693 17 . . . cord-007788-09t52zix 694 1 Vasodilators vasodilator NNS cord-007788-09t52zix 694 2 and and CC cord-007788-09t52zix 694 3 renin renin NN cord-007788-09t52zix 694 4 - - HYPH cord-007788-09t52zix 694 5 angiotensin angiotensin NN cord-007788-09t52zix 694 6 antagonists antagonist NNS cord-007788-09t52zix 694 7 may may MD cord-007788-09t52zix 694 8 also also RB cord-007788-09t52zix 694 9 be be VB cord-007788-09t52zix 694 10 used use VBN cord-007788-09t52zix 694 11 to to TO cord-007788-09t52zix 694 12 treat treat VB cord-007788-09t52zix 694 13 hypertension hypertension NN cord-007788-09t52zix 694 14 . . . cord-007788-09t52zix 695 1 It -PRON- PRP cord-007788-09t52zix 695 2 is be VBZ cord-007788-09t52zix 695 3 recommended recommend VBN cord-007788-09t52zix 695 4 to to TO cord-007788-09t52zix 695 5 restrict restrict VB cord-007788-09t52zix 695 6 platelet platelet NN cord-007788-09t52zix 695 7 transfusion transfusion NN cord-007788-09t52zix 695 8 in in IN cord-007788-09t52zix 695 9 microangiopathic microangiopathic JJ cord-007788-09t52zix 695 10 disease disease NN cord-007788-09t52zix 695 11 , , , cord-007788-09t52zix 695 12 but but CC cord-007788-09t52zix 695 13 this this DT cord-007788-09t52zix 695 14 is be VBZ cord-007788-09t52zix 695 15 often often RB cord-007788-09t52zix 695 16 impossible impossible JJ cord-007788-09t52zix 695 17 due due IN cord-007788-09t52zix 695 18 to to IN cord-007788-09t52zix 695 19 the the DT cord-007788-09t52zix 695 20 need need NN cord-007788-09t52zix 695 21 to to TO cord-007788-09t52zix 695 22 prevent prevent VB cord-007788-09t52zix 695 23 bleeding bleeding NN cord-007788-09t52zix 695 24 complications complication NNS cord-007788-09t52zix 695 25 . . . cord-007788-09t52zix 696 1 A a DT cord-007788-09t52zix 696 2 potential potential JJ cord-007788-09t52zix 696 3 treatment treatment NN cord-007788-09t52zix 696 4 for for IN cord-007788-09t52zix 696 5 TMA TMA NNP cord-007788-09t52zix 696 6 is be VBZ cord-007788-09t52zix 696 7 eculizumab eculizumab NNS cord-007788-09t52zix 696 8 . . . cord-007788-09t52zix 697 1 Eculizumab Eculizumab NNP cord-007788-09t52zix 697 2 stops stop VBZ cord-007788-09t52zix 697 3 the the DT cord-007788-09t52zix 697 4 complement complement NN cord-007788-09t52zix 697 5 - - HYPH cord-007788-09t52zix 697 6 activating activate VBG cord-007788-09t52zix 697 7 cascade cascade NN cord-007788-09t52zix 697 8 preventing prevent VBG cord-007788-09t52zix 697 9 formation formation NN cord-007788-09t52zix 697 10 of of IN cord-007788-09t52zix 697 11 C5b-9 c5b-9 NN cord-007788-09t52zix 697 12 . . . cord-007788-09t52zix 698 1 This this DT cord-007788-09t52zix 698 2 leads lead VBZ cord-007788-09t52zix 698 3 to to IN cord-007788-09t52zix 698 4 hampering hampering NN cord-007788-09t52zix 698 5 of of IN cord-007788-09t52zix 698 6 the the DT cord-007788-09t52zix 698 7 intravascular intravascular JJ cord-007788-09t52zix 698 8 haemolysis haemolysis NN cord-007788-09t52zix 698 9 . . . cord-007788-09t52zix 699 1 Eculizumab Eculizumab NNP cord-007788-09t52zix 699 2 has have VBZ cord-007788-09t52zix 699 3 shown show VBN cord-007788-09t52zix 699 4 effect effect NN cord-007788-09t52zix 699 5 when when WRB cord-007788-09t52zix 699 6 started start VBD cord-007788-09t52zix 699 7 early early RB cord-007788-09t52zix 699 8 after after IN cord-007788-09t52zix 699 9 diagnosis diagnosis NN cord-007788-09t52zix 700 1 ( ( -LRB- cord-007788-09t52zix 700 2 Jodele Jodele NNP cord-007788-09t52zix 700 3 et et NNP cord-007788-09t52zix 700 4 al al NNP cord-007788-09t52zix 700 5 . . NNP cord-007788-09t52zix 700 6 2015 2015 CD cord-007788-09t52zix 700 7 ) ) -RRB- cord-007788-09t52zix 700 8 . . . cord-007788-09t52zix 701 1 Monitoring monitor VBG cord-007788-09t52zix 701 2 for for IN cord-007788-09t52zix 701 3 effect effect NN cord-007788-09t52zix 701 4 by by IN cord-007788-09t52zix 701 5 following follow VBG cord-007788-09t52zix 701 6 serum serum NN cord-007788-09t52zix 701 7 concentration concentration NN cord-007788-09t52zix 701 8 levels level NNS cord-007788-09t52zix 701 9 is be VBZ cord-007788-09t52zix 701 10 important important JJ cord-007788-09t52zix 701 11 , , , cord-007788-09t52zix 701 12 and and CC cord-007788-09t52zix 701 13 dose dose NN cord-007788-09t52zix 701 14 adjustments adjustment NNS cord-007788-09t52zix 701 15 may may MD cord-007788-09t52zix 701 16 be be VB cord-007788-09t52zix 701 17 necessary necessary JJ cord-007788-09t52zix 701 18 to to TO cord-007788-09t52zix 701 19 reach reach VB cord-007788-09t52zix 701 20 and and CC cord-007788-09t52zix 701 21 maintain maintain VB cord-007788-09t52zix 701 22 the the DT cord-007788-09t52zix 701 23 desired desire VBN cord-007788-09t52zix 701 24 therapeutic therapeutic JJ cord-007788-09t52zix 701 25 levels level NNS cord-007788-09t52zix 701 26 and and CC cord-007788-09t52zix 701 27 effect effect NN cord-007788-09t52zix 701 28 . . . cord-007788-09t52zix 702 1 In in IN cord-007788-09t52zix 702 2 a a DT cord-007788-09t52zix 702 3 small small JJ cord-007788-09t52zix 702 4 number number NN cord-007788-09t52zix 702 5 of of IN cord-007788-09t52zix 702 6 cases case NNS cord-007788-09t52zix 702 7 , , , cord-007788-09t52zix 702 8 successful successful JJ cord-007788-09t52zix 702 9 treatment treatment NN cord-007788-09t52zix 702 10 with with IN cord-007788-09t52zix 702 11 rituximab rituximab NN cord-007788-09t52zix 702 12 and and CC cord-007788-09t52zix 702 13 other other JJ cord-007788-09t52zix 702 14 monoclonal monoclonal JJ cord-007788-09t52zix 702 15 antibodies antibody NNS cord-007788-09t52zix 702 16 has have VBZ cord-007788-09t52zix 702 17 been be VBN cord-007788-09t52zix 702 18 reported report VBN cord-007788-09t52zix 702 19 . . . cord-007788-09t52zix 703 1 Treatment treatment NN cord-007788-09t52zix 703 2 attempts attempt NNS cord-007788-09t52zix 703 3 have have VBP cord-007788-09t52zix 703 4 also also RB cord-007788-09t52zix 703 5 been be VBN cord-007788-09t52zix 703 6 made make VBN cord-007788-09t52zix 703 7 with with IN cord-007788-09t52zix 703 8 defibrotide defibrotide NN cord-007788-09t52zix 703 9 at at IN cord-007788-09t52zix 703 10 the the DT cord-007788-09t52zix 703 11 same same JJ cord-007788-09t52zix 703 12 dosing dosing NN cord-007788-09t52zix 703 13 as as IN cord-007788-09t52zix 703 14 approved approve VBN cord-007788-09t52zix 703 15 for for IN cord-007788-09t52zix 703 16 treatment treatment NN cord-007788-09t52zix 703 17 of of IN cord-007788-09t52zix 703 18 severe severe JJ cord-007788-09t52zix 703 19 sinusoidal sinusoidal JJ cord-007788-09t52zix 703 20 obstruction obstruction NN cord-007788-09t52zix 703 21 syndrome syndrome NN cord-007788-09t52zix 703 22 / / SYM cord-007788-09t52zix 703 23 veno veno NNP cord-007788-09t52zix 703 24 - - HYPH cord-007788-09t52zix 703 25 occlusive occlusive JJ cord-007788-09t52zix 703 26 disease disease NN cord-007788-09t52zix 703 27 ( ( -LRB- cord-007788-09t52zix 703 28 SOS SOS NNP cord-007788-09t52zix 703 29 / / SYM cord-007788-09t52zix 703 30 VOD VOD NNP cord-007788-09t52zix 703 31 ) ) -RRB- cord-007788-09t52zix 703 32 but but CC cord-007788-09t52zix 703 33 with with IN cord-007788-09t52zix 703 34 variable variable JJ cord-007788-09t52zix 703 35 results result NNS cord-007788-09t52zix 703 36 . . . cord-007788-09t52zix 704 1 Total total JJ cord-007788-09t52zix 704 2 plasma plasma NN cord-007788-09t52zix 704 3 exchange exchange NN cord-007788-09t52zix 704 4 ( ( -LRB- cord-007788-09t52zix 704 5 TPE TPE NNP cord-007788-09t52zix 704 6 ) ) -RRB- cord-007788-09t52zix 704 7 has have VBZ cord-007788-09t52zix 704 8 been be VBN cord-007788-09t52zix 704 9 tried try VBN cord-007788-09t52zix 704 10 due due IN cord-007788-09t52zix 704 11 to to IN cord-007788-09t52zix 704 12 the the DT cord-007788-09t52zix 704 13 clinical clinical JJ cord-007788-09t52zix 704 14 similarities similarity NNS cord-007788-09t52zix 704 15 between between IN cord-007788-09t52zix 704 16 TAM TAM NNP cord-007788-09t52zix 704 17 and and CC cord-007788-09t52zix 704 18 TTP TTP NNP cord-007788-09t52zix 704 19 , , , cord-007788-09t52zix 704 20 but but CC cord-007788-09t52zix 704 21 where where WRB cord-007788-09t52zix 704 22 TTP TTP NNP cord-007788-09t52zix 704 23 can can MD cord-007788-09t52zix 704 24 be be VB cord-007788-09t52zix 704 25 successfully successfully RB cord-007788-09t52zix 704 26 treated treat VBN cord-007788-09t52zix 704 27 with with IN cord-007788-09t52zix 704 28 TPE TPE NNP cord-007788-09t52zix 704 29 , , , cord-007788-09t52zix 704 30 it -PRON- PRP cord-007788-09t52zix 704 31 is be VBZ cord-007788-09t52zix 704 32 not not RB cord-007788-09t52zix 704 33 recommended recommend VBN cord-007788-09t52zix 704 34 for for IN cord-007788-09t52zix 704 35 TAM TAM NNP cord-007788-09t52zix 704 36 due due IN cord-007788-09t52zix 704 37 to to IN cord-007788-09t52zix 704 38 poor poor JJ cord-007788-09t52zix 704 39 response response NN cord-007788-09t52zix 704 40 rates rate NNS cord-007788-09t52zix 704 41 . . . cord-007788-09t52zix 705 1 Careful careful JJ cord-007788-09t52zix 705 2 assessments assessment NNS cord-007788-09t52zix 705 3 will will MD cord-007788-09t52zix 705 4 facilitate facilitate VB cord-007788-09t52zix 705 5 early early JJ cord-007788-09t52zix 705 6 diagnosis diagnosis NN cord-007788-09t52zix 705 7 of of IN cord-007788-09t52zix 705 8 , , , cord-007788-09t52zix 705 9 or or CC cord-007788-09t52zix 705 10 ruling rule VBG cord-007788-09t52zix 705 11 out out RP cord-007788-09t52zix 705 12 , , , cord-007788-09t52zix 705 13 TMA TMA NNP cord-007788-09t52zix 705 14 and and CC cord-007788-09t52zix 705 15 thus thus RB cord-007788-09t52zix 705 16 improves improve VBZ cord-007788-09t52zix 705 17 the the DT cord-007788-09t52zix 705 18 outcome outcome NN cord-007788-09t52zix 705 19 . . . cord-007788-09t52zix 706 1 Close close JJ cord-007788-09t52zix 706 2 monitoring monitoring NN cord-007788-09t52zix 706 3 of of IN cord-007788-09t52zix 706 4 vital vital JJ cord-007788-09t52zix 706 5 signs sign NNS cord-007788-09t52zix 706 6 and and CC cord-007788-09t52zix 706 7 being be VBG cord-007788-09t52zix 706 8 alert alert JJ cord-007788-09t52zix 706 9 to to IN cord-007788-09t52zix 706 10 any any DT cord-007788-09t52zix 706 11 changes change NNS cord-007788-09t52zix 706 12 or or CC cord-007788-09t52zix 706 13 trends trend NNS cord-007788-09t52zix 706 14 is be VBZ cord-007788-09t52zix 706 15 standard standard JJ cord-007788-09t52zix 706 16 . . . cord-007788-09t52zix 707 1 Keeping keep VBG cord-007788-09t52zix 707 2 track track NN cord-007788-09t52zix 707 3 of of IN cord-007788-09t52zix 707 4 fluid fluid JJ cord-007788-09t52zix 707 5 balance balance NN cord-007788-09t52zix 707 6 and and CC cord-007788-09t52zix 707 7 weight weight NN cord-007788-09t52zix 707 8 is be VBZ cord-007788-09t52zix 707 9 equally equally RB cord-007788-09t52zix 707 10 important important JJ cord-007788-09t52zix 707 11 . . . cord-007788-09t52zix 708 1 Blood blood NN cord-007788-09t52zix 708 2 pressure pressure NN cord-007788-09t52zix 708 3 should should MD cord-007788-09t52zix 708 4 be be VB cord-007788-09t52zix 708 5 kept keep VBN cord-007788-09t52zix 708 6 below below IN cord-007788-09t52zix 708 7 140/90 140/90 NN cord-007788-09t52zix 708 8 in in IN cord-007788-09t52zix 708 9 adult adult NN cord-007788-09t52zix 708 10 patients patient NNS cord-007788-09t52zix 708 11 ( ( -LRB- cord-007788-09t52zix 708 12 Jodele Jodele NNP cord-007788-09t52zix 708 13 et et NNP cord-007788-09t52zix 708 14 al al NNP cord-007788-09t52zix 708 15 . . NNP cord-007788-09t52zix 708 16 2015 2015 CD cord-007788-09t52zix 708 17 ) ) -RRB- cord-007788-09t52zix 708 18 . . . cord-007788-09t52zix 709 1 The the DT cord-007788-09t52zix 709 2 patient patient NN cord-007788-09t52zix 709 3 's 's POS cord-007788-09t52zix 709 4 urine urine NN cord-007788-09t52zix 709 5 should should MD cord-007788-09t52zix 709 6 be be VB cord-007788-09t52zix 709 7 monitored monitor VBN cord-007788-09t52zix 709 8 for for IN cord-007788-09t52zix 709 9 proteinuria proteinuria NN cord-007788-09t52zix 709 10 and and CC cord-007788-09t52zix 709 11 the the DT cord-007788-09t52zix 709 12 patient patient NN cord-007788-09t52zix 709 13 instructed instruct VBD cord-007788-09t52zix 709 14 about about IN cord-007788-09t52zix 709 15 what what WP cord-007788-09t52zix 709 16 abnormal abnormal JJ cord-007788-09t52zix 709 17 findings finding NNS cord-007788-09t52zix 709 18 and and CC cord-007788-09t52zix 709 19 symptoms symptom NNS cord-007788-09t52zix 709 20 to to TO cord-007788-09t52zix 709 21 look look VB cord-007788-09t52zix 709 22 for for IN cord-007788-09t52zix 709 23 and and CC cord-007788-09t52zix 709 24 to to TO cord-007788-09t52zix 709 25 notify notify VB cord-007788-09t52zix 709 26 staff staff NN cord-007788-09t52zix 709 27 of of IN cord-007788-09t52zix 709 28 any any DT cord-007788-09t52zix 709 29 discomfort discomfort NN cord-007788-09t52zix 709 30 including include VBG cord-007788-09t52zix 709 31 signs sign NNS cord-007788-09t52zix 709 32 of of IN cord-007788-09t52zix 709 33 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 709 34 bleeding bleeding NN cord-007788-09t52zix 709 35 . . . cord-007788-09t52zix 710 1 If if IN cord-007788-09t52zix 710 2 invasive invasive JJ cord-007788-09t52zix 710 3 tests test NNS cord-007788-09t52zix 710 4 such such JJ cord-007788-09t52zix 710 5 as as IN cord-007788-09t52zix 710 6 biopsies biopsy NNS cord-007788-09t52zix 710 7 are be VBP cord-007788-09t52zix 710 8 to to TO cord-007788-09t52zix 710 9 be be VB cord-007788-09t52zix 710 10 performed perform VBN cord-007788-09t52zix 710 11 , , , cord-007788-09t52zix 710 12 proper proper JJ cord-007788-09t52zix 710 13 preparation preparation NN cord-007788-09t52zix 710 14 and and CC cord-007788-09t52zix 710 15 support support NN cord-007788-09t52zix 710 16 is be VBZ cord-007788-09t52zix 710 17 vital vital JJ cord-007788-09t52zix 710 18 . . . cord-007788-09t52zix 711 1 If if IN cord-007788-09t52zix 711 2 pharmacological pharmacological JJ cord-007788-09t52zix 711 3 treatment treatment NN cord-007788-09t52zix 711 4 with with IN cord-007788-09t52zix 711 5 eculizumab eculizumab NNS cord-007788-09t52zix 711 6 is be VBZ cord-007788-09t52zix 711 7 started start VBN cord-007788-09t52zix 711 8 , , , cord-007788-09t52zix 711 9 serum serum NN cord-007788-09t52zix 711 10 level level NN cord-007788-09t52zix 711 11 concentration concentration NN cord-007788-09t52zix 711 12 needs need VBZ cord-007788-09t52zix 711 13 to to TO cord-007788-09t52zix 711 14 be be VB cord-007788-09t52zix 711 15 followed follow VBN cord-007788-09t52zix 711 16 . . . cord-007788-09t52zix 712 1 Treatment treatment NN cord-007788-09t52zix 712 2 with with IN cord-007788-09t52zix 712 3 rituximab rituximab NN cord-007788-09t52zix 712 4 and and CC cord-007788-09t52zix 712 5 defibrotide defibrotide NN cord-007788-09t52zix 712 6 should should MD cord-007788-09t52zix 712 7 be be VB cord-007788-09t52zix 712 8 administered administer VBN cord-007788-09t52zix 712 9 as as IN cord-007788-09t52zix 712 10 ordered order VBN cord-007788-09t52zix 712 11 , , , cord-007788-09t52zix 712 12 and and CC cord-007788-09t52zix 712 13 the the DT cord-007788-09t52zix 712 14 patient patient NN cord-007788-09t52zix 712 15 should should MD cord-007788-09t52zix 712 16 be be VB cord-007788-09t52zix 712 17 monitored monitor VBN cord-007788-09t52zix 712 18 accordingly accordingly RB cord-007788-09t52zix 712 19 for for IN cord-007788-09t52zix 712 20 effect effect NN cord-007788-09t52zix 712 21 and and CC cord-007788-09t52zix 712 22 side side NN cord-007788-09t52zix 712 23 effects effect NNS cord-007788-09t52zix 712 24 . . . cord-007788-09t52zix 713 1 Since since IN cord-007788-09t52zix 713 2 the the DT cord-007788-09t52zix 713 3 onset onset NN cord-007788-09t52zix 713 4 of of IN cord-007788-09t52zix 713 5 TAM TAM NNP cord-007788-09t52zix 713 6 can can MD cord-007788-09t52zix 713 7 occur occur VB cord-007788-09t52zix 713 8 after after IN cord-007788-09t52zix 713 9 discharge discharge NN cord-007788-09t52zix 713 10 from from IN cord-007788-09t52zix 713 11 the the DT cord-007788-09t52zix 713 12 transplant transplant NN cord-007788-09t52zix 713 13 unit unit NN cord-007788-09t52zix 713 14 , , , cord-007788-09t52zix 713 15 it -PRON- PRP cord-007788-09t52zix 713 16 is be VBZ cord-007788-09t52zix 713 17 important important JJ cord-007788-09t52zix 713 18 to to TO cord-007788-09t52zix 713 19 be be VB cord-007788-09t52zix 713 20 observant observant JJ cord-007788-09t52zix 713 21 to to IN cord-007788-09t52zix 713 22 symptoms symptom NNS cord-007788-09t52zix 713 23 and and CC cord-007788-09t52zix 713 24 consider consider VB cord-007788-09t52zix 713 25 this this DT cord-007788-09t52zix 713 26 diagnosis diagnosis NN cord-007788-09t52zix 713 27 even even RB cord-007788-09t52zix 713 28 in in IN cord-007788-09t52zix 713 29 the the DT cord-007788-09t52zix 713 30 outpatient outpatient NN cord-007788-09t52zix 713 31 setting setting NN cord-007788-09t52zix 713 32 . . . cord-007788-09t52zix 714 1 Open open VB cord-007788-09t52zix 714 2 Access Access NNP cord-007788-09t52zix 715 1 This this DT cord-007788-09t52zix 715 2 chapter chapter NN cord-007788-09t52zix 715 3 is be VBZ cord-007788-09t52zix 715 4 licensed license VBN cord-007788-09t52zix 715 5 under under IN cord-007788-09t52zix 715 6 the the DT cord-007788-09t52zix 715 7 terms term NNS cord-007788-09t52zix 715 8 of of IN cord-007788-09t52zix 715 9 the the DT cord-007788-09t52zix 715 10 Creative Creative NNP cord-007788-09t52zix 715 11 Commons Commons NNP cord-007788-09t52zix 715 12 Attribution Attribution NNP cord-007788-09t52zix 715 13 4.0 4.0 CD cord-007788-09t52zix 715 14 International International NNP cord-007788-09t52zix 715 15 License license NN cord-007788-09t52zix 715 16 ( ( -LRB- cord-007788-09t52zix 715 17 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/ NNP cord-007788-09t52zix 715 18 ) ) -RRB- cord-007788-09t52zix 715 19 , , , cord-007788-09t52zix 715 20 which which WDT cord-007788-09t52zix 715 21 permits permit VBZ cord-007788-09t52zix 715 22 use use NN cord-007788-09t52zix 715 23 , , , cord-007788-09t52zix 715 24 sharing sharing NN cord-007788-09t52zix 715 25 , , , cord-007788-09t52zix 715 26 adaptation adaptation NN cord-007788-09t52zix 715 27 , , , cord-007788-09t52zix 715 28 distribution distribution NN cord-007788-09t52zix 715 29 and and CC cord-007788-09t52zix 715 30 reproduction reproduction NN cord-007788-09t52zix 715 31 in in IN cord-007788-09t52zix 715 32 any any DT cord-007788-09t52zix 715 33 medium medium NN cord-007788-09t52zix 715 34 or or CC cord-007788-09t52zix 715 35 format format NN cord-007788-09t52zix 715 36 , , , cord-007788-09t52zix 715 37 as as RB cord-007788-09t52zix 715 38 long long RB cord-007788-09t52zix 715 39 as as IN cord-007788-09t52zix 715 40 you -PRON- PRP cord-007788-09t52zix 715 41 give give VBP cord-007788-09t52zix 715 42 appropriate appropriate JJ cord-007788-09t52zix 715 43 credit credit NN cord-007788-09t52zix 715 44 to to IN cord-007788-09t52zix 715 45 the the DT cord-007788-09t52zix 715 46 original original JJ cord-007788-09t52zix 715 47 author(s author(s NNP cord-007788-09t52zix 715 48 ) ) -RRB- cord-007788-09t52zix 715 49 and and CC cord-007788-09t52zix 715 50 the the DT cord-007788-09t52zix 715 51 source source NN cord-007788-09t52zix 715 52 , , , cord-007788-09t52zix 715 53 provide provide VB cord-007788-09t52zix 715 54 a a DT cord-007788-09t52zix 715 55 link link NN cord-007788-09t52zix 715 56 to to IN cord-007788-09t52zix 715 57 the the DT cord-007788-09t52zix 715 58 Creative Creative NNP cord-007788-09t52zix 715 59 Commons Commons NNP cord-007788-09t52zix 715 60 license license NN cord-007788-09t52zix 715 61 and and CC cord-007788-09t52zix 715 62 indicate indicate VBP cord-007788-09t52zix 715 63 if if IN cord-007788-09t52zix 715 64 changes change NNS cord-007788-09t52zix 715 65 were be VBD cord-007788-09t52zix 715 66 made make VBN cord-007788-09t52zix 715 67 . . . cord-007788-09t52zix 716 1 The the DT cord-007788-09t52zix 716 2 images image NNS cord-007788-09t52zix 716 3 or or CC cord-007788-09t52zix 716 4 other other JJ cord-007788-09t52zix 716 5 third third JJ cord-007788-09t52zix 716 6 party party NN cord-007788-09t52zix 716 7 material material NN cord-007788-09t52zix 716 8 in in IN cord-007788-09t52zix 716 9 this this DT cord-007788-09t52zix 716 10 chapter chapter NN cord-007788-09t52zix 716 11 are be VBP cord-007788-09t52zix 716 12 included include VBN cord-007788-09t52zix 716 13 in in IN cord-007788-09t52zix 716 14 the the DT cord-007788-09t52zix 716 15 chapter chapter NN cord-007788-09t52zix 716 16 's 's POS cord-007788-09t52zix 716 17 Creative Creative NNP cord-007788-09t52zix 716 18 Commons Commons NNP cord-007788-09t52zix 716 19 license license NN cord-007788-09t52zix 716 20 , , , cord-007788-09t52zix 716 21 unless unless IN cord-007788-09t52zix 716 22 indicated indicate VBN cord-007788-09t52zix 716 23 otherwise otherwise RB cord-007788-09t52zix 716 24 in in IN cord-007788-09t52zix 716 25 a a DT cord-007788-09t52zix 716 26 credit credit NN cord-007788-09t52zix 716 27 line line NN cord-007788-09t52zix 716 28 to to IN cord-007788-09t52zix 716 29 the the DT cord-007788-09t52zix 716 30 material material NN cord-007788-09t52zix 716 31 . . . cord-007788-09t52zix 717 1 If if IN cord-007788-09t52zix 717 2 material material NN cord-007788-09t52zix 717 3 is be VBZ cord-007788-09t52zix 717 4 not not RB cord-007788-09t52zix 717 5 included include VBN cord-007788-09t52zix 717 6 in in IN cord-007788-09t52zix 717 7 the the DT cord-007788-09t52zix 717 8 chapter chapter NN cord-007788-09t52zix 717 9 's 's POS cord-007788-09t52zix 717 10 Creative Creative NNP cord-007788-09t52zix 717 11 Commons Commons NNP cord-007788-09t52zix 717 12 license license NN cord-007788-09t52zix 717 13 and and CC cord-007788-09t52zix 717 14 your -PRON- PRP$ cord-007788-09t52zix 717 15 intended intend VBN cord-007788-09t52zix 717 16 use use NN cord-007788-09t52zix 717 17 is be VBZ cord-007788-09t52zix 717 18 not not RB cord-007788-09t52zix 717 19 permitted permit VBN cord-007788-09t52zix 717 20 by by IN cord-007788-09t52zix 717 21 statutory statutory JJ cord-007788-09t52zix 717 22 regulation regulation NN cord-007788-09t52zix 717 23 or or CC cord-007788-09t52zix 717 24 exceeds exceed VBZ cord-007788-09t52zix 717 25 the the DT cord-007788-09t52zix 717 26 permitted permit VBN cord-007788-09t52zix 717 27 use use NN cord-007788-09t52zix 717 28 , , , cord-007788-09t52zix 717 29 you -PRON- PRP cord-007788-09t52zix 717 30 will will MD cord-007788-09t52zix 717 31 need need VB cord-007788-09t52zix 717 32 to to TO cord-007788-09t52zix 717 33 obtain obtain VB cord-007788-09t52zix 717 34 permission permission NN cord-007788-09t52zix 717 35 directly directly RB cord-007788-09t52zix 717 36 from from IN cord-007788-09t52zix 717 37 the the DT cord-007788-09t52zix 717 38 copyright copyright NN cord-007788-09t52zix 717 39 holder holder NN cord-007788-09t52zix 717 40 . . . cord-007788-09t52zix 718 1 Outcome outcome NN cord-007788-09t52zix 718 2 of of IN cord-007788-09t52zix 718 3 Diffuse Diffuse NNP cord-007788-09t52zix 718 4 Alveolar Alveolar NNP cord-007788-09t52zix 718 5 Hemorrhage Hemorrhage NNP cord-007788-09t52zix 718 6 in in IN cord-007788-09t52zix 718 7 Hematopoietic Hematopoietic NNP cord-007788-09t52zix 718 8 Stem Stem NNP cord-007788-09t52zix 718 9 Cell Cell NNP cord-007788-09t52zix 718 10 Transplant transplant NN cord-007788-09t52zix 718 11 Recipients recipient NNS cord-007788-09t52zix 718 12 Risk risk NN cord-007788-09t52zix 718 13 factors factor NNS cord-007788-09t52zix 718 14 and and CC cord-007788-09t52zix 718 15 outcome outcome NN cord-007788-09t52zix 718 16 of of IN cord-007788-09t52zix 718 17 pulmonary pulmonary JJ cord-007788-09t52zix 718 18 complications complication NNS cord-007788-09t52zix 718 19 after after IN cord-007788-09t52zix 718 20 autologous autologous JJ cord-007788-09t52zix 718 21 hematopoietic hematopoietic JJ cord-007788-09t52zix 718 22 stem stem NN cord-007788-09t52zix 718 23 cell cell NN cord-007788-09t52zix 718 24 transplant transplant NN cord-007788-09t52zix 718 25 Emerging emerge VBG cord-007788-09t52zix 718 26 evidence evidence NN cord-007788-09t52zix 718 27 of of IN cord-007788-09t52zix 718 28 the the DT cord-007788-09t52zix 718 29 pathobiology pathobiology NN cord-007788-09t52zix 718 30 of of IN cord-007788-09t52zix 718 31 mucositis mucositis NNP cord-007788-09t52zix 718 32 Implementation Implementation NNP cord-007788-09t52zix 718 33 of of IN cord-007788-09t52zix 718 34 a a DT cord-007788-09t52zix 718 35 standardised standardised JJ cord-007788-09t52zix 718 36 protocol protocol NN cord-007788-09t52zix 718 37 for for IN cord-007788-09t52zix 718 38 prevention prevention NN cord-007788-09t52zix 718 39 and and CC cord-007788-09t52zix 718 40 management management NN cord-007788-09t52zix 718 41 on on IN cord-007788-09t52zix 718 42 oral oral JJ cord-007788-09t52zix 718 43 mucositis mucositis NN cord-007788-09t52zix 718 44 in in IN cord-007788-09t52zix 718 45 patients patient NNS cord-007788-09t52zix 718 46 undergoing undergo VBG cord-007788-09t52zix 718 47 haematopoitiec haematopoitiec JJ cord-007788-09t52zix 718 48 stem stem NN cord-007788-09t52zix 718 49 cell cell NN cord-007788-09t52zix 718 50 transplant transplant NN cord-007788-09t52zix 718 51 EBMT EBMT NNP cord-007788-09t52zix 718 52 - - HYPH cord-007788-09t52zix 718 53 ESH ESH NNP cord-007788-09t52zix 718 54 handbook handbook NN cord-007788-09t52zix 718 55 on on IN cord-007788-09t52zix 718 56 haematopoietic haematopoietic JJ cord-007788-09t52zix 718 57 stem stem NN cord-007788-09t52zix 718 58 cell cell NN cord-007788-09t52zix 718 59 transplantation transplantation NN cord-007788-09t52zix 719 1 How how WRB cord-007788-09t52zix 719 2 I -PRON- PRP cord-007788-09t52zix 719 3 manage manage VBP cord-007788-09t52zix 719 4 sinusoidal sinusoidal JJ cord-007788-09t52zix 719 5 obstruction obstruction NN cord-007788-09t52zix 719 6 syndrome syndrome NN cord-007788-09t52zix 719 7 after after IN cord-007788-09t52zix 719 8 haematopoietic haematopoietic JJ cord-007788-09t52zix 719 9 cell cell NN cord-007788-09t52zix 719 10 transplantation transplantation NN cord-007788-09t52zix 719 11 et et NNP cord-007788-09t52zix 719 12 al al NNP cord-007788-09t52zix 719 13 ngraftment ngraftment NNP cord-007788-09t52zix 719 14 syndrome syndrome NN cord-007788-09t52zix 719 15 after after IN cord-007788-09t52zix 719 16 allogeneic allogeneic JJ cord-007788-09t52zix 719 17 hematopoietic hematopoietic JJ cord-007788-09t52zix 719 18 cell cell NN cord-007788-09t52zix 719 19 transplantation transplantation NN cord-007788-09t52zix 719 20 predicts predict VBZ cord-007788-09t52zix 719 21 poor poor JJ cord-007788-09t52zix 719 22 outcomes outcome NNS cord-007788-09t52zix 720 1 An an DT cord-007788-09t52zix 720 2 update update NN cord-007788-09t52zix 720 3 on on IN cord-007788-09t52zix 720 4 pulmonary pulmonary JJ cord-007788-09t52zix 720 5 complications complication NNS cord-007788-09t52zix 720 6 of of IN cord-007788-09t52zix 720 7 hematopoietic hematopoietic JJ cord-007788-09t52zix 720 8 stem stem NN cord-007788-09t52zix 720 9 cell cell NN cord-007788-09t52zix 720 10 transplantation transplantation NN cord-007788-09t52zix 720 11 Pulmonary pulmonary JJ cord-007788-09t52zix 720 12 function function NN cord-007788-09t52zix 720 13 testing test VBG cord-007788-09t52zix 720 14 prior prior RB cord-007788-09t52zix 720 15 to to IN cord-007788-09t52zix 720 16 hematopoietic hematopoietic JJ cord-007788-09t52zix 720 17 stem stem NN cord-007788-09t52zix 720 18 cell cell NN cord-007788-09t52zix 720 19 transplantation transplantation NN cord-007788-09t52zix 720 20 Validation validation NN cord-007788-09t52zix 720 21 of of IN cord-007788-09t52zix 720 22 recently recently RB cord-007788-09t52zix 720 23 proposed propose VBN cord-007788-09t52zix 720 24 consensus consensus NN cord-007788-09t52zix 720 25 criteria criterion NNS cord-007788-09t52zix 720 26 for for IN cord-007788-09t52zix 720 27 thrombotic thrombotic JJ cord-007788-09t52zix 720 28 Microangiopathy Microangiopathy NNP cord-007788-09t52zix 720 29 after after IN cord-007788-09t52zix 720 30 allogeneic allogeneic JJ cord-007788-09t52zix 720 31 hematopoietic hematopoietic JJ cord-007788-09t52zix 720 32 stem stem NN cord-007788-09t52zix 720 33 - - HYPH cord-007788-09t52zix 720 34 cell cell NN cord-007788-09t52zix 720 35 transplantation transplantation NN cord-007788-09t52zix 720 36 Interventions intervention NNS cord-007788-09t52zix 720 37 for for IN cord-007788-09t52zix 720 38 treating treat VBG cord-007788-09t52zix 720 39 oral oral JJ cord-007788-09t52zix 720 40 mucositis mucositis NN cord-007788-09t52zix 720 41 for for IN cord-007788-09t52zix 720 42 patients patient NNS cord-007788-09t52zix 720 43 with with IN cord-007788-09t52zix 720 44 cancer cancer NN cord-007788-09t52zix 720 45 receiving receive VBG cord-007788-09t52zix 720 46 treatment treatment NN cord-007788-09t52zix 720 47 ( ( -LRB- cord-007788-09t52zix 720 48 review review NN cord-007788-09t52zix 720 49 ) ) -RRB- cord-007788-09t52zix 720 50 Cochrane Cochrane NNP cord-007788-09t52zix 720 51 Library Library NNP cord-007788-09t52zix 720 52 Hepatic Hepatic NNP cord-007788-09t52zix 720 53 veno veno NNP cord-007788-09t52zix 720 54 - - HYPH cord-007788-09t52zix 720 55 occlusive occlusive JJ cord-007788-09t52zix 720 56 disease disease NN cord-007788-09t52zix 720 57 following follow VBG cord-007788-09t52zix 720 58 stem stem NN cord-007788-09t52zix 720 59 cell cell NN cord-007788-09t52zix 720 60 transplantation transplantation NN cord-007788-09t52zix 720 61 : : : cord-007788-09t52zix 720 62 incidence incidence NN cord-007788-09t52zix 720 63 , , , cord-007788-09t52zix 720 64 clinical clinical JJ cord-007788-09t52zix 720 65 course course NN cord-007788-09t52zix 720 66 and and CC cord-007788-09t52zix 720 67 outcome outcome VB cord-007788-09t52zix 720 68 Defibrotide Defibrotide NNP cord-007788-09t52zix 720 69 for for IN cord-007788-09t52zix 720 70 prophylaxis prophylaxis NN cord-007788-09t52zix 720 71 of of IN cord-007788-09t52zix 720 72 hepatic hepatic JJ cord-007788-09t52zix 720 73 veno veno NN cord-007788-09t52zix 720 74 - - HYPH cord-007788-09t52zix 720 75 occlusive occlusive JJ cord-007788-09t52zix 720 76 disease disease NN cord-007788-09t52zix 720 77 in in IN cord-007788-09t52zix 720 78 paediatric paediatric JJ cord-007788-09t52zix 720 79 haemopoietic haemopoietic JJ cord-007788-09t52zix 720 80 stem stem NN cord-007788-09t52zix 720 81 - - HYPH cord-007788-09t52zix 720 82 cell cell NN cord-007788-09t52zix 720 83 transplantation transplantation NN cord-007788-09t52zix 720 84 : : : cord-007788-09t52zix 720 85 an an DT cord-007788-09t52zix 720 86 open open JJ cord-007788-09t52zix 720 87 - - HYPH cord-007788-09t52zix 720 88 label label NN cord-007788-09t52zix 720 89 , , , cord-007788-09t52zix 720 90 phase phase NN cord-007788-09t52zix 720 91 3 3 CD cord-007788-09t52zix 720 92 , , , cord-007788-09t52zix 720 93 randomised randomise VBN cord-007788-09t52zix 720 94 controlled control VBN cord-007788-09t52zix 720 95 trial trial NN cord-007788-09t52zix 720 96 Diagnosis diagnosis NN cord-007788-09t52zix 720 97 and and CC cord-007788-09t52zix 720 98 severity severity NN cord-007788-09t52zix 720 99 criteria criterion NNS cord-007788-09t52zix 720 100 for for IN cord-007788-09t52zix 720 101 sinusoidal sinusoidal JJ cord-007788-09t52zix 720 102 obstruction obstruction NN cord-007788-09t52zix 720 103 syndrome syndrome NN cord-007788-09t52zix 720 104 / / SYM cord-007788-09t52zix 720 105 veno veno NNP cord-007788-09t52zix 720 106 - - HYPH cord-007788-09t52zix 720 107 occlusive occlusive JJ cord-007788-09t52zix 720 108 disease disease NN cord-007788-09t52zix 720 109 in in IN cord-007788-09t52zix 720 110 pediatric pediatric JJ cord-007788-09t52zix 720 111 patients patient NNS cord-007788-09t52zix 720 112 : : : cord-007788-09t52zix 720 113 a a DT cord-007788-09t52zix 720 114 new new JJ cord-007788-09t52zix 720 115 classification classification NN cord-007788-09t52zix 720 116 from from IN cord-007788-09t52zix 720 117 the the DT cord-007788-09t52zix 720 118 European european JJ cord-007788-09t52zix 720 119 society society NN cord-007788-09t52zix 720 120 for for IN cord-007788-09t52zix 720 121 blood blood NN cord-007788-09t52zix 720 122 and and CC cord-007788-09t52zix 720 123 marrow marrow NN cord-007788-09t52zix 720 124 transplantation transplantation NN cord-007788-09t52zix 720 125 Bone bone NN cord-007788-09t52zix 720 126 Marrow Marrow NNP cord-007788-09t52zix 720 127 Transpl Transpl NNP cord-007788-09t52zix 720 128 . . . cord-007788-09t52zix 721 1 Advance advance JJ cord-007788-09t52zix 721 2 online online JJ cord-007788-09t52zix 721 3 publication publication NN cord-007788-09t52zix 721 4 Engraftment Engraftment NNP cord-007788-09t52zix 721 5 syndrome syndrome NN cord-007788-09t52zix 721 6 after after IN cord-007788-09t52zix 721 7 autologous autologous JJ cord-007788-09t52zix 721 8 stem stem NN cord-007788-09t52zix 721 9 cell cell NN cord-007788-09t52zix 721 10 transplantation transplantation NN cord-007788-09t52zix 721 11 : : : cord-007788-09t52zix 721 12 an an DT cord-007788-09t52zix 721 13 update update NN cord-007788-09t52zix 721 14 unifying unify VBG cord-007788-09t52zix 721 15 the the DT cord-007788-09t52zix 721 16 definition definition NN cord-007788-09t52zix 721 17 and and CC cord-007788-09t52zix 721 18 management management NN cord-007788-09t52zix 721 19 approach approach NN cord-007788-09t52zix 721 20 The the DT cord-007788-09t52zix 721 21 sepsis sepsis NN cord-007788-09t52zix 721 22 six six CD cord-007788-09t52zix 721 23 and and CC cord-007788-09t52zix 721 24 the the DT cord-007788-09t52zix 721 25 severe severe JJ cord-007788-09t52zix 721 26 sepsis sepsis NN cord-007788-09t52zix 721 27 resuscitation resuscitation NN cord-007788-09t52zix 721 28 bundle bundle NN cord-007788-09t52zix 721 29 : : : cord-007788-09t52zix 721 30 a a DT cord-007788-09t52zix 721 31 prospective prospective JJ cord-007788-09t52zix 721 32 observational observational JJ cord-007788-09t52zix 721 33 cohort cohort NN cord-007788-09t52zix 721 34 study study NN cord-007788-09t52zix 721 35 Vascular vascular JJ cord-007788-09t52zix 721 36 disorders disorder NNS cord-007788-09t52zix 721 37 of of IN cord-007788-09t52zix 721 38 the the DT cord-007788-09t52zix 721 39 liver liver NN cord-007788-09t52zix 721 40 Hemorrhagic hemorrhagic JJ cord-007788-09t52zix 721 41 cystitis cystitis NN cord-007788-09t52zix 721 42 after after IN cord-007788-09t52zix 721 43 allogeneic allogeneic NN cord-007788-09t52zix 721 44 hematopoietic hematopoietic JJ cord-007788-09t52zix 721 45 stem stem NN cord-007788-09t52zix 721 46 cell cell NN cord-007788-09t52zix 721 47 transplants transplant NNS cord-007788-09t52zix 721 48 is be VBZ cord-007788-09t52zix 721 49 the the DT cord-007788-09t52zix 721 50 complex complex JJ cord-007788-09t52zix 721 51 result result NN cord-007788-09t52zix 721 52 of of IN cord-007788-09t52zix 721 53 BK BK NNP cord-007788-09t52zix 721 54 virus virus NN cord-007788-09t52zix 721 55 infection infection NN cord-007788-09t52zix 721 56 , , , cord-007788-09t52zix 721 57 preparative preparative JJ cord-007788-09t52zix 721 58 regimen regimen NN cord-007788-09t52zix 721 59 intensity intensity NN cord-007788-09t52zix 721 60 and and CC cord-007788-09t52zix 721 61 donor donor NN cord-007788-09t52zix 721 62 type type NN cord-007788-09t52zix 721 63 Major major JJ cord-007788-09t52zix 721 64 pulmonary pulmonary JJ cord-007788-09t52zix 721 65 complications complication NNS cord-007788-09t52zix 721 66 after after IN cord-007788-09t52zix 721 67 hematopoietic hematopoietic JJ cord-007788-09t52zix 721 68 stem stem NN cord-007788-09t52zix 721 69 cell cell NN cord-007788-09t52zix 721 70 transplant transplant NN cord-007788-09t52zix 722 1 BCSH BCSH NNP cord-007788-09t52zix 722 2 / / SYM cord-007788-09t52zix 722 3 BSBMT BSBMT NNP cord-007788-09t52zix 722 4 guideline guideline NN cord-007788-09t52zix 722 5 : : : cord-007788-09t52zix 722 6 diagnosis diagnosis NN cord-007788-09t52zix 722 7 and and CC cord-007788-09t52zix 722 8 management management NN cord-007788-09t52zix 722 9 of of IN cord-007788-09t52zix 722 10 veno veno NNP cord-007788-09t52zix 722 11 - - HYPH cord-007788-09t52zix 722 12 occlusive occlusive JJ cord-007788-09t52zix 722 13 disease disease NN cord-007788-09t52zix 722 14 ( ( -LRB- cord-007788-09t52zix 722 15 sinusoidal sinusoidal JJ cord-007788-09t52zix 722 16 obstruction obstruction NN cord-007788-09t52zix 722 17 syndrome syndrome NN cord-007788-09t52zix 722 18 ) ) -RRB- cord-007788-09t52zix 722 19 following follow VBG cord-007788-09t52zix 722 20 haematopoietic haematopoietic JJ cord-007788-09t52zix 722 21 stem stem NN cord-007788-09t52zix 722 22 cell cell NN cord-007788-09t52zix 722 23 transplantation transplantation NN cord-007788-09t52zix 722 24 Prevention prevention NN cord-007788-09t52zix 722 25 of of IN cord-007788-09t52zix 722 26 cyclophosphamide cyclophosphamide NN cord-007788-09t52zix 722 27 - - HYPH cord-007788-09t52zix 722 28 induced induce VBN cord-007788-09t52zix 722 29 hemorrhagic hemorrhagic JJ cord-007788-09t52zix 722 30 cystitis cystitis NN cord-007788-09t52zix 722 31 Polyomavirus Polyomavirus NNP cord-007788-09t52zix 722 32 BK BK NNP cord-007788-09t52zix 722 33 infection infection NN cord-007788-09t52zix 722 34 in in IN cord-007788-09t52zix 722 35 blood blood NN cord-007788-09t52zix 722 36 and and CC cord-007788-09t52zix 722 37 marrow marrow NN cord-007788-09t52zix 722 38 transplant transplant NN cord-007788-09t52zix 722 39 recipients recipient NNS cord-007788-09t52zix 722 40 Overnight overnight JJ cord-007788-09t52zix 722 41 storage storage NN cord-007788-09t52zix 722 42 of of IN cord-007788-09t52zix 722 43 removable removable JJ cord-007788-09t52zix 722 44 dentures denture NNS cord-007788-09t52zix 722 45 in in IN cord-007788-09t52zix 722 46 alkaline alkaline JJ cord-007788-09t52zix 722 47 peroxidebased peroxidebased JJ cord-007788-09t52zix 722 48 tablets tablet NNS cord-007788-09t52zix 722 49 affects affect VBZ cord-007788-09t52zix 722 50 biofilm biofilm NN cord-007788-09t52zix 722 51 mass mass NN cord-007788-09t52zix 722 52 and and CC cord-007788-09t52zix 722 53 composition composition NN cord-007788-09t52zix 722 54 Basic basic JJ cord-007788-09t52zix 722 55 oral oral JJ cord-007788-09t52zix 722 56 care care NN cord-007788-09t52zix 722 57 for for IN cord-007788-09t52zix 722 58 haematologyoncology haematologyoncology NN cord-007788-09t52zix 722 59 patients patient NNS cord-007788-09t52zix 722 60 and and CC cord-007788-09t52zix 722 61 hematopoietic hematopoietic JJ cord-007788-09t52zix 722 62 stem stem NN cord-007788-09t52zix 722 63 cell cell NN cord-007788-09t52zix 722 64 transplantation transplantation NN cord-007788-09t52zix 722 65 : : : cord-007788-09t52zix 723 1 A a DT cord-007788-09t52zix 723 2 postion postion NN cord-007788-09t52zix 723 3 paper paper NN cord-007788-09t52zix 723 4 from from IN cord-007788-09t52zix 723 5 the the DT cord-007788-09t52zix 723 6 jont jont NNP cord-007788-09t52zix 723 7 task task NNP cord-007788-09t52zix 723 8 force force NN cord-007788-09t52zix 723 9 of of IN cord-007788-09t52zix 723 10 the the DT cord-007788-09t52zix 723 11 multinational multinational NNP cord-007788-09t52zix 723 12 association association NNP cord-007788-09t52zix 723 13 of of IN cord-007788-09t52zix 723 14 supportive supportive NNP cord-007788-09t52zix 723 15 care care NNP cord-007788-09t52zix 723 16 / / SYM cord-007788-09t52zix 723 17 international international JJ cord-007788-09t52zix 723 18 society society NN cord-007788-09t52zix 723 19 for for IN cord-007788-09t52zix 723 20 oral oral JJ cord-007788-09t52zix 723 21 oncology oncology NN cord-007788-09t52zix 723 22 and and CC cord-007788-09t52zix 723 23 the the DT cord-007788-09t52zix 723 24 European european JJ cord-007788-09t52zix 723 25 group group NN cord-007788-09t52zix 723 26 for for IN cord-007788-09t52zix 723 27 blood blood NN cord-007788-09t52zix 723 28 and and CC cord-007788-09t52zix 723 29 marrow marrow NN cord-007788-09t52zix 723 30 transplantation transplantation NN cord-007788-09t52zix 723 31 Development Development NNP cord-007788-09t52zix 723 32 , , , cord-007788-09t52zix 723 33 testing testing NN cord-007788-09t52zix 723 34 , , , cord-007788-09t52zix 723 35 and and CC cord-007788-09t52zix 723 36 application application NN cord-007788-09t52zix 723 37 of of IN cord-007788-09t52zix 723 38 the the DT cord-007788-09t52zix 723 39 oral oral JJ cord-007788-09t52zix 723 40 assessment assessment NN cord-007788-09t52zix 723 41 guide guide NN cord-007788-09t52zix 724 1 Hepatic hepatic JJ cord-007788-09t52zix 724 2 sinusoidal sinusoidal JJ cord-007788-09t52zix 724 3 obstruction obstruction NN cord-007788-09t52zix 724 4 syndrome syndrome NN cord-007788-09t52zix 724 5 in in IN cord-007788-09t52zix 724 6 patients patient NNS cord-007788-09t52zix 724 7 undergoing undergo VBG cord-007788-09t52zix 724 8 hematopoietic hematopoietic JJ cord-007788-09t52zix 724 9 stem stem NN cord-007788-09t52zix 724 10 cell cell NN cord-007788-09t52zix 724 11 transplant transplant NN cord-007788-09t52zix 724 12 Basic basic JJ cord-007788-09t52zix 724 13 oral oral JJ cord-007788-09t52zix 724 14 care care NN cord-007788-09t52zix 724 15 for for IN cord-007788-09t52zix 724 16 hematology hematology NN cord-007788-09t52zix 724 17 - - HYPH cord-007788-09t52zix 724 18 oncology oncology NN cord-007788-09t52zix 724 19 patients patient NNS cord-007788-09t52zix 724 20 and and CC cord-007788-09t52zix 724 21 hematopoietic hematopoietic JJ cord-007788-09t52zix 724 22 stem stem NN cord-007788-09t52zix 724 23 cell cell NN cord-007788-09t52zix 724 24 transplantation transplantation NN cord-007788-09t52zix 724 25 recipients recipient NNS cord-007788-09t52zix 724 26 : : : cord-007788-09t52zix 724 27 a a DT cord-007788-09t52zix 724 28 position position NN cord-007788-09t52zix 724 29 paper paper NN cord-007788-09t52zix 724 30 from from IN cord-007788-09t52zix 724 31 the the DT cord-007788-09t52zix 724 32 joint joint JJ cord-007788-09t52zix 724 33 task task NN cord-007788-09t52zix 724 34 force force NN cord-007788-09t52zix 724 35 of of IN cord-007788-09t52zix 724 36 the the DT cord-007788-09t52zix 724 37 Multinational Multinational NNP cord-007788-09t52zix 724 38 Association Association NNP cord-007788-09t52zix 724 39 of of IN cord-007788-09t52zix 724 40 Supportive Supportive NNP cord-007788-09t52zix 724 41 Care Care NNP cord-007788-09t52zix 724 42 in in IN cord-007788-09t52zix 724 43 Cancer Cancer NNP cord-007788-09t52zix 724 44 / / SYM cord-007788-09t52zix 724 45 International International NNP cord-007788-09t52zix 724 46 Society Society NNP cord-007788-09t52zix 724 47 of of IN cord-007788-09t52zix 724 48 Oral Oral NNP cord-007788-09t52zix 724 49 Oncology Oncology NNP cord-007788-09t52zix 725 1 ( ( -LRB- cord-007788-09t52zix 725 2 MASCC MASCC NNP cord-007788-09t52zix 725 3 / / SYM cord-007788-09t52zix 725 4 ISOO ISOO NNP cord-007788-09t52zix 725 5 ) ) -RRB- cord-007788-09t52zix 725 6 and and CC cord-007788-09t52zix 725 7 the the DT cord-007788-09t52zix 725 8 European European NNP cord-007788-09t52zix 725 9 Group Group NNP cord-007788-09t52zix 725 10 for for IN cord-007788-09t52zix 725 11 Blood Blood NNP cord-007788-09t52zix 725 12 and and CC cord-007788-09t52zix 725 13 Marrow Marrow NNP cord-007788-09t52zix 725 14 Transplantation transplantation NN cord-007788-09t52zix 725 15 ( ( -LRB- cord-007788-09t52zix 725 16 EBMT EBMT NNP cord-007788-09t52zix 725 17 ) ) -RRB- cord-007788-09t52zix 726 1 A a DT cord-007788-09t52zix 726 2 critical critical JJ cord-007788-09t52zix 726 3 care care NN cord-007788-09t52zix 726 4 and and CC cord-007788-09t52zix 726 5 transplantationbased transplantationbase VBD cord-007788-09t52zix 726 6 approach approach NN cord-007788-09t52zix 726 7 to to IN cord-007788-09t52zix 726 8 acute acute JJ cord-007788-09t52zix 726 9 respiratory respiratory JJ cord-007788-09t52zix 726 10 failure failure NN cord-007788-09t52zix 726 11 after after IN cord-007788-09t52zix 726 12 hematopoietic hematopoietic JJ cord-007788-09t52zix 726 13 stem stem NN cord-007788-09t52zix 726 14 cell cell NN cord-007788-09t52zix 726 15 transplantation transplantation NN cord-007788-09t52zix 726 16 in in IN cord-007788-09t52zix 726 17 children child NNS cord-007788-09t52zix 726 18 Mucosal Mucosal NNP cord-007788-09t52zix 726 19 injury injury NN cord-007788-09t52zix 726 20 in in IN cord-007788-09t52zix 726 21 patients patient NNS cord-007788-09t52zix 726 22 undergoing undergo VBG cord-007788-09t52zix 726 23 hematopoietic hematopoietic JJ cord-007788-09t52zix 726 24 progenitor progenitor NN cord-007788-09t52zix 726 25 cell cell NN cord-007788-09t52zix 726 26 transplantation transplantation NN cord-007788-09t52zix 726 27 : : : cord-007788-09t52zix 726 28 new new JJ cord-007788-09t52zix 726 29 approaches approach NNS cord-007788-09t52zix 726 30 to to IN cord-007788-09t52zix 726 31 prophylaxis prophylaxis NN cord-007788-09t52zix 726 32 and and CC cord-007788-09t52zix 726 33 treatment treatment NN cord-007788-09t52zix 726 34 Acute acute JJ cord-007788-09t52zix 726 35 phase phase NN cord-007788-09t52zix 726 36 after after IN cord-007788-09t52zix 726 37 haematopoietic haematopoietic JJ cord-007788-09t52zix 726 38 stem stem NN cord-007788-09t52zix 726 39 cell cell NN cord-007788-09t52zix 726 40 transplantation transplantation NN cord-007788-09t52zix 727 1 -bleeding -bleede VBG cord-007788-09t52zix 727 2 and and CC cord-007788-09t52zix 727 3 thrombotic thrombotic JJ cord-007788-09t52zix 727 4 complications complication NNS cord-007788-09t52zix 727 5 2012 2012 CD cord-007788-09t52zix 727 6 Blood blood NN cord-007788-09t52zix 727 7 and and CC cord-007788-09t52zix 727 8 marrow marrow NN cord-007788-09t52zix 727 9 transplant transplant NN cord-007788-09t52zix 727 10 clinical clinical JJ cord-007788-09t52zix 727 11 trials trial NNS cord-007788-09t52zix 727 12 network network NN cord-007788-09t52zix 727 13 toxicity toxicity NNP cord-007788-09t52zix 727 14 committee committee NNP cord-007788-09t52zix 727 15 consensus consensus NN cord-007788-09t52zix 727 16 summary summary NN cord-007788-09t52zix 727 17 : : : cord-007788-09t52zix 727 18 thrombotic thrombotic JJ cord-007788-09t52zix 727 19 Microangiopathy Microangiopathy NNP cord-007788-09t52zix 727 20 after after IN cord-007788-09t52zix 727 21 hematopoietic hematopoietic JJ cord-007788-09t52zix 727 22 stem stem NN cord-007788-09t52zix 727 23 cell cell NN cord-007788-09t52zix 727 24 transplantation transplantation NN cord-007788-09t52zix 728 1 A a DT cord-007788-09t52zix 728 2 new new JJ cord-007788-09t52zix 728 3 paradigm paradigm NN cord-007788-09t52zix 728 4 : : : cord-007788-09t52zix 728 5 Diagnosis diagnosis NN cord-007788-09t52zix 728 6 and and CC cord-007788-09t52zix 728 7 management management NN cord-007788-09t52zix 728 8 of of IN cord-007788-09t52zix 728 9 HSCT HSCT NNP cord-007788-09t52zix 728 10 - - HYPH cord-007788-09t52zix 728 11 associated associate VBN cord-007788-09t52zix 728 12 thrombotic thrombotic JJ cord-007788-09t52zix 728 13 microangiopathy microangiopathy NNP cord-007788-09t52zix 728 14 as as IN cord-007788-09t52zix 728 15 multi multi JJ cord-007788-09t52zix 728 16 - - JJ cord-007788-09t52zix 728 17 system system JJ cord-007788-09t52zix 728 18 endothelial endothelial JJ cord-007788-09t52zix 728 19 injury injury NN cord-007788-09t52zix 728 20 Venoocclusive Venoocclusive NNP cord-007788-09t52zix 728 21 disease disease NN cord-007788-09t52zix 728 22 of of IN cord-007788-09t52zix 728 23 the the DT cord-007788-09t52zix 728 24 liver liver NN cord-007788-09t52zix 728 25 following follow VBG cord-007788-09t52zix 728 26 bone bone NN cord-007788-09t52zix 728 27 marrow marrow NN cord-007788-09t52zix 728 28 transplantation transplantation NN cord-007788-09t52zix 728 29 Defibrotide Defibrotide NNP cord-007788-09t52zix 728 30 : : : cord-007788-09t52zix 729 1 A a DT cord-007788-09t52zix 729 2 review review NN cord-007788-09t52zix 729 3 of of IN cord-007788-09t52zix 729 4 its -PRON- PRP$ cord-007788-09t52zix 729 5 use use NN cord-007788-09t52zix 729 6 in in IN cord-007788-09t52zix 729 7 severe severe JJ cord-007788-09t52zix 729 8 hepatic hepatic JJ cord-007788-09t52zix 729 9 Veno Veno NNP cord-007788-09t52zix 729 10 - - HYPH cord-007788-09t52zix 729 11 occlusive occlusive JJ cord-007788-09t52zix 729 12 disease disease NN cord-007788-09t52zix 729 13 following follow VBG cord-007788-09t52zix 729 14 haematopoietic haematopoietic JJ cord-007788-09t52zix 729 15 stem stem NN cord-007788-09t52zix 729 16 cell cell NN cord-007788-09t52zix 729 17 transplantation transplantation NN cord-007788-09t52zix 729 18 Diagnostic diagnostic JJ cord-007788-09t52zix 729 19 yield yield NN cord-007788-09t52zix 729 20 of of IN cord-007788-09t52zix 729 21 timing time VBG cord-007788-09t52zix 729 22 blood blood NN cord-007788-09t52zix 729 23 culture culture NN cord-007788-09t52zix 729 24 collection collection NN cord-007788-09t52zix 729 25 relative relative JJ cord-007788-09t52zix 729 26 to to IN cord-007788-09t52zix 729 27 fever fever NN cord-007788-09t52zix 729 28 Oral oral JJ cord-007788-09t52zix 729 29 graft graft NN cord-007788-09t52zix 729 30 - - HYPH cord-007788-09t52zix 729 31 versushost versushost NN cord-007788-09t52zix 729 32 disease disease NN cord-007788-09t52zix 729 33 Evidence evidence NN cord-007788-09t52zix 729 34 - - HYPH cord-007788-09t52zix 729 35 based base VBN cord-007788-09t52zix 729 36 clinical clinical JJ cord-007788-09t52zix 729 37 practice practice NN cord-007788-09t52zix 729 38 guidelines guideline NNS cord-007788-09t52zix 729 39 for for IN cord-007788-09t52zix 729 40 the the DT cord-007788-09t52zix 729 41 management management NN cord-007788-09t52zix 729 42 of of IN cord-007788-09t52zix 729 43 Mucositis Mucositis NNP cord-007788-09t52zix 729 44 Secondary Secondary NNP cord-007788-09t52zix 729 45 to to IN cord-007788-09t52zix 729 46 Cancer cancer NN cord-007788-09t52zix 729 47 Therapy therapy NN cord-007788-09t52zix 730 1 ( ( -LRB- cord-007788-09t52zix 730 2 MASCC/ MASCC/ NNP cord-007788-09t52zix 730 3 ISOO ISOO NNP cord-007788-09t52zix 730 4 review review NN cord-007788-09t52zix 730 5 ) ) -RRB- cord-007788-09t52zix 731 1 Polyoma Polyoma NNP cord-007788-09t52zix 731 2 BK BK NNP cord-007788-09t52zix 731 3 virus virus NN cord-007788-09t52zix 731 4 and and CC cord-007788-09t52zix 731 5 haemorrhagic haemorrhagic JJ cord-007788-09t52zix 731 6 cystitis cystitis NN cord-007788-09t52zix 731 7 in in IN cord-007788-09t52zix 731 8 haematopoietic haematopoietic JJ cord-007788-09t52zix 731 9 stem stem NN cord-007788-09t52zix 731 10 cell cell NN cord-007788-09t52zix 731 11 transplantation transplantation NN cord-007788-09t52zix 731 12 : : : cord-007788-09t52zix 731 13 a a DT cord-007788-09t52zix 731 14 changing change VBG cord-007788-09t52zix 731 15 paradigm paradigm NN cord-007788-09t52zix 731 16 Engraftment Engraftment NNP cord-007788-09t52zix 731 17 syndrome syndrome NN cord-007788-09t52zix 732 1 following follow VBG cord-007788-09t52zix 733 1 autologous autologous JJ cord-007788-09t52zix 733 2 hematopoietic hematopoietic JJ cord-007788-09t52zix 733 3 stem stem NN cord-007788-09t52zix 733 4 cell cell NN cord-007788-09t52zix 733 5 transplantation transplantation NN cord-007788-09t52zix 733 6 Diffuse diffuse VBP cord-007788-09t52zix 733 7 alveolar alveolar NN cord-007788-09t52zix 733 8 Hemorrhage hemorrhage NN cord-007788-09t52zix 733 9 and and CC cord-007788-09t52zix 733 10 infection infection NN cord-007788-09t52zix 733 11 - - HYPH cord-007788-09t52zix 733 12 associated associate VBN cord-007788-09t52zix 733 13 alveolar alveolar NN cord-007788-09t52zix 733 14 Hemorrhage hemorrhage NN cord-007788-09t52zix 733 15 following follow VBG cord-007788-09t52zix 733 16 hematopoietic hematopoietic JJ cord-007788-09t52zix 733 17 stem stem NN cord-007788-09t52zix 733 18 cell cell NN cord-007788-09t52zix 733 19 transplantation transplantation NN cord-007788-09t52zix 733 20 : : : cord-007788-09t52zix 733 21 related related JJ cord-007788-09t52zix 733 22 and and CC cord-007788-09t52zix 733 23 high high JJ cord-007788-09t52zix 733 24 - - HYPH cord-007788-09t52zix 733 25 risk risk NN cord-007788-09t52zix 733 26 clinical clinical JJ cord-007788-09t52zix 733 27 syndromes syndrome NNS cord-007788-09t52zix 734 1 Venoocclusive venoocclusive JJ cord-007788-09t52zix 734 2 disease disease NN cord-007788-09t52zix 734 3 of of IN cord-007788-09t52zix 734 4 the the DT cord-007788-09t52zix 734 5 liver liver NN cord-007788-09t52zix 734 6 after after IN cord-007788-09t52zix 734 7 bone bone NN cord-007788-09t52zix 734 8 marrow marrow NN cord-007788-09t52zix 734 9 transplantation transplantation NN cord-007788-09t52zix 734 10 : : : cord-007788-09t52zix 734 11 diagnosis diagnosis NN cord-007788-09t52zix 734 12 , , , cord-007788-09t52zix 734 13 incidence incidence NN cord-007788-09t52zix 734 14 and and CC cord-007788-09t52zix 734 15 predisposing predisposing NN cord-007788-09t52zix 734 16 factors factor NNS cord-007788-09t52zix 734 17 Veno Veno NNP cord-007788-09t52zix 734 18 - - HYPH cord-007788-09t52zix 734 19 occlusive occlusive JJ cord-007788-09t52zix 734 20 disease disease NN cord-007788-09t52zix 734 21 of of IN cord-007788-09t52zix 734 22 the the DT cord-007788-09t52zix 734 23 liver liver NN cord-007788-09t52zix 734 24 and and CC cord-007788-09t52zix 734 25 multi multi JJ cord-007788-09t52zix 734 26 organ organ NN cord-007788-09t52zix 734 27 failure failure NN cord-007788-09t52zix 734 28 after after IN cord-007788-09t52zix 734 29 bone bone NN cord-007788-09t52zix 734 30 marrow marrow NN cord-007788-09t52zix 734 31 transplantation transplantation NN cord-007788-09t52zix 734 32 : : : cord-007788-09t52zix 734 33 a a DT cord-007788-09t52zix 734 34 cohort cohort NN cord-007788-09t52zix 734 35 study study NN cord-007788-09t52zix 734 36 of of IN cord-007788-09t52zix 735 1 355 355 CD cord-007788-09t52zix 735 2 patients patient NNS cord-007788-09t52zix 735 3 Mesna Mesna NNP cord-007788-09t52zix 735 4 Summary Summary NNP cord-007788-09t52zix 735 5 of of IN cord-007788-09t52zix 735 6 Product Product NNP cord-007788-09t52zix 735 7 Characteristics Characteristics NNP cord-007788-09t52zix 735 8 ( ( -LRB- cord-007788-09t52zix 735 9 SPC SPC NNP cord-007788-09t52zix 735 10 ) ) -RRB- cord-007788-09t52zix 736 1 Sinusoidal sinusoidal JJ cord-007788-09t52zix 736 2 obstruction obstruction NN cord-007788-09t52zix 736 3 syndrome syndrome NN cord-007788-09t52zix 736 4 / / SYM cord-007788-09t52zix 736 5 venoocclusive venoocclusive JJ cord-007788-09t52zix 736 6 disease disease NN cord-007788-09t52zix 736 7 : : : cord-007788-09t52zix 736 8 current current JJ cord-007788-09t52zix 736 9 situation situation NN cord-007788-09t52zix 736 10 and and CC cord-007788-09t52zix 736 11 perspectives perspective NNS cord-007788-09t52zix 736 12 - - : cord-007788-09t52zix 736 13 a a DT cord-007788-09t52zix 736 14 position position NN cord-007788-09t52zix 736 15 statement statement NN cord-007788-09t52zix 736 16 from from IN cord-007788-09t52zix 736 17 the the DT cord-007788-09t52zix 736 18 European European NNP cord-007788-09t52zix 736 19 Society Society NNP cord-007788-09t52zix 736 20 for for IN cord-007788-09t52zix 736 21 Blood blood NN cord-007788-09t52zix 736 22 and and CC cord-007788-09t52zix 736 23 Marrow marrow NN cord-007788-09t52zix 736 24 Transplantation transplantation NN cord-007788-09t52zix 736 25 ( ( -LRB- cord-007788-09t52zix 736 26 EBMT EBMT NNP cord-007788-09t52zix 736 27 ) ) -RRB- cord-007788-09t52zix 737 1 Revised revise VBN cord-007788-09t52zix 737 2 diagnosis diagnosis NN cord-007788-09t52zix 737 3 and and CC cord-007788-09t52zix 737 4 severity severity NN cord-007788-09t52zix 737 5 criteria criterion NNS cord-007788-09t52zix 737 6 for for IN cord-007788-09t52zix 737 7 sinusoidal sinusoidal JJ cord-007788-09t52zix 737 8 obstruction obstruction NN cord-007788-09t52zix 737 9 syndrome syndrome NN cord-007788-09t52zix 737 10 / / SYM cord-007788-09t52zix 737 11 veno veno NNP cord-007788-09t52zix 737 12 - - HYPH cord-007788-09t52zix 737 13 occlusive occlusive JJ cord-007788-09t52zix 737 14 disease disease NN cord-007788-09t52zix 737 15 in in IN cord-007788-09t52zix 737 16 adult adult NN cord-007788-09t52zix 737 17 patients patient NNS cord-007788-09t52zix 737 18 : : : cord-007788-09t52zix 737 19 a a DT cord-007788-09t52zix 737 20 new new JJ cord-007788-09t52zix 737 21 classification classification NN cord-007788-09t52zix 737 22 from from IN cord-007788-09t52zix 737 23 the the DT cord-007788-09t52zix 737 24 European European NNP cord-007788-09t52zix 737 25 Society Society NNP cord-007788-09t52zix 737 26 for for IN cord-007788-09t52zix 737 27 Blood blood NN cord-007788-09t52zix 737 28 and and CC cord-007788-09t52zix 737 29 Marrow Marrow NNP cord-007788-09t52zix 737 30 Transplantation Transplantation NNP cord-007788-09t52zix 737 31 Thrombotic thrombotic JJ cord-007788-09t52zix 737 32 complications complication NNS cord-007788-09t52zix 737 33 associated associate VBN cord-007788-09t52zix 737 34 with with IN cord-007788-09t52zix 737 35 stem stem NN cord-007788-09t52zix 737 36 cell cell NN cord-007788-09t52zix 737 37 transplantation transplantation NN cord-007788-09t52zix 737 38 Oral oral JJ cord-007788-09t52zix 737 39 mucositis mucositis NNP cord-007788-09t52zix 737 40 chemoradiotherapy chemoradiotherapy NN cord-007788-09t52zix 737 41 and and CC cord-007788-09t52zix 737 42 hematopoietic hematopoietic JJ cord-007788-09t52zix 737 43 stem stem NN cord-007788-09t52zix 737 44 cell cell NN cord-007788-09t52zix 737 45 transplantation transplantation NN cord-007788-09t52zix 737 46 patients patient NNS cord-007788-09t52zix 737 47 management management NN cord-007788-09t52zix 737 48 Utility Utility NNP cord-007788-09t52zix 737 49 of of IN cord-007788-09t52zix 737 50 routine routine JJ cord-007788-09t52zix 737 51 surveillance surveillance NN cord-007788-09t52zix 737 52 blood blood NN cord-007788-09t52zix 737 53 cultures culture NNS cord-007788-09t52zix 737 54 in in IN cord-007788-09t52zix 737 55 asymptomatic asymptomatic JJ cord-007788-09t52zix 737 56 allogeneic allogeneic IN cord-007788-09t52zix 737 57 hematopoietic hematopoietic JJ cord-007788-09t52zix 737 58 stem stem NN cord-007788-09t52zix 737 59 cell cell NN cord-007788-09t52zix 737 60 transplant transplant NN cord-007788-09t52zix 737 61 recipients recipient NNS cord-007788-09t52zix 737 62 with with IN cord-007788-09t52zix 737 63 indwelling indwell VBG cord-007788-09t52zix 737 64 central central JJ cord-007788-09t52zix 737 65 venous venous JJ cord-007788-09t52zix 737 66 catheters catheter NNS cord-007788-09t52zix 737 67 at at IN cord-007788-09t52zix 737 68 a a DT cord-007788-09t52zix 737 69 comprehensive comprehensive JJ cord-007788-09t52zix 737 70 cancer cancer NN cord-007788-09t52zix 737 71 center center NN cord-007788-09t52zix 737 72 American American NNP cord-007788-09t52zix 737 73 Thoracic Thoracic NNP cord-007788-09t52zix 737 74 Society Society NNP cord-007788-09t52zix 737 75 Committee Committee NNP cord-007788-09t52zix 737 76 on on IN cord-007788-09t52zix 737 77 idiopathic idiopathic JJ cord-007788-09t52zix 737 78 pneumonia pneumonia NN cord-007788-09t52zix 737 79 syndrome syndrome NN cord-007788-09t52zix 737 80 . . . cord-007788-09t52zix 738 1 An an DT cord-007788-09t52zix 738 2 official official JJ cord-007788-09t52zix 738 3 American American NNP cord-007788-09t52zix 738 4 Thoracic Thoracic NNP cord-007788-09t52zix 738 5 Society Society NNP cord-007788-09t52zix 738 6 research research NN cord-007788-09t52zix 738 7 statement statement NN cord-007788-09t52zix 738 8 : : : cord-007788-09t52zix 738 9 noninfectious noninfectious JJ cord-007788-09t52zix 738 10 lung lung NN cord-007788-09t52zix 738 11 injury injury NN cord-007788-09t52zix 738 12 after after IN cord-007788-09t52zix 738 13 hematopoietic hematopoietic JJ cord-007788-09t52zix 738 14 stem stem NN cord-007788-09t52zix 738 15 cell cell NN cord-007788-09t52zix 738 16 transplantation transplantation NN cord-007788-09t52zix 738 17 : : : cord-007788-09t52zix 738 18 idiopathic idiopathic JJ cord-007788-09t52zix 738 19 pneumonia pneumonia NN cord-007788-09t52zix 738 20 syndrome syndrome NN cord-007788-09t52zix 739 1 Diffuse diffuse JJ cord-007788-09t52zix 739 2 alveolar alveolar NN cord-007788-09t52zix 739 3 Hemorrhage hemorrhage NN cord-007788-09t52zix 739 4 on on IN cord-007788-09t52zix 739 5 behalf behalf NN cord-007788-09t52zix 739 6 of of IN cord-007788-09t52zix 739 7 the the DT cord-007788-09t52zix 739 8 ESMO ESMO NNP cord-007788-09t52zix 739 9 Guidelines Guidelines NNPS cord-007788-09t52zix 739 10 Committee Committee NNP cord-007788-09t52zix 739 11 . . . cord-007788-09t52zix 740 1 Management management NN cord-007788-09t52zix 740 2 of of IN cord-007788-09t52zix 740 3 oral oral JJ cord-007788-09t52zix 740 4 and and CC cord-007788-09t52zix 740 5 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 740 6 mucosal mucosal JJ cord-007788-09t52zix 740 7 injury injury NN cord-007788-09t52zix 740 8 : : : cord-007788-09t52zix 740 9 ESMO ESMO NNP cord-007788-09t52zix 740 10 clinical clinical JJ cord-007788-09t52zix 740 11 practice practice NN cord-007788-09t52zix 740 12 guidelines guideline NNS cord-007788-09t52zix 740 13 for for IN cord-007788-09t52zix 740 14 diagnosis diagnosis NN cord-007788-09t52zix 740 15 , , , cord-007788-09t52zix 740 16 treatment treatment NN cord-007788-09t52zix 740 17 , , , cord-007788-09t52zix 740 18 and and CC cord-007788-09t52zix 740 19 follow follow NN cord-007788-09t52zix 740 20 - - HYPH cord-007788-09t52zix 740 21 up up RP cord-007788-09t52zix 740 22 United United NNP cord-007788-09t52zix 740 23 Kingdom Kingdom NNP cord-007788-09t52zix 740 24 oral oral JJ cord-007788-09t52zix 740 25 care care NN cord-007788-09t52zix 740 26 in in IN cord-007788-09t52zix 740 27 cancer cancer NN cord-007788-09t52zix 740 28 guidance guidance NN cord-007788-09t52zix 740 29 : : : cord-007788-09t52zix 740 30 second second NNP cord-007788-09t52zix 740 31 edition edition NN cord-007788-09t52zix 740 32 . . . cord-007788-09t52zix 741 1 www.ukomic.co www.ukomic.co NNP cord-007788-09t52zix 742 1 Guidelines guideline NNS cord-007788-09t52zix 742 2 for for IN cord-007788-09t52zix 742 3 the the DT cord-007788-09t52zix 742 4 assessment assessment NN cord-007788-09t52zix 742 5 of of IN cord-007788-09t52zix 742 6 oral oral JJ cord-007788-09t52zix 742 7 mucositis mucositis NN cord-007788-09t52zix 742 8 in in IN cord-007788-09t52zix 742 9 adult adult NN cord-007788-09t52zix 742 10 chemotherapy chemotherapy NN cord-007788-09t52zix 742 11 , , , cord-007788-09t52zix 742 12 radiotherapy radiotherapy NN cord-007788-09t52zix 742 13 and and CC cord-007788-09t52zix 742 14 haematopoietic haematopoietic JJ cord-007788-09t52zix 742 15 stem stem NN cord-007788-09t52zix 742 16 cell cell NN cord-007788-09t52zix 742 17 transplant transplant NN cord-007788-09t52zix 743 1 patients patient NNS cord-007788-09t52zix 743 2 Severe severe JJ cord-007788-09t52zix 743 3 respiratory respiratory JJ cord-007788-09t52zix 743 4 failure failure NN cord-007788-09t52zix 743 5 due due JJ cord-007788-09t52zix 743 6 to to TO cord-007788-09t52zix 743 7 diffuse diffuse VB cord-007788-09t52zix 743 8 alveolar alveolar NN cord-007788-09t52zix 743 9 hemorrhage hemorrhage NN cord-007788-09t52zix 743 10 : : : cord-007788-09t52zix 743 11 clinical clinical JJ cord-007788-09t52zix 743 12 characteristics characteristic NNS cord-007788-09t52zix 743 13 and and CC cord-007788-09t52zix 743 14 outcome outcome NN cord-007788-09t52zix 743 15 of of IN cord-007788-09t52zix 743 16 intensive intensive JJ cord-007788-09t52zix 743 17 care care NN cord-007788-09t52zix 743 18 Drug Drug NNP cord-007788-09t52zix 743 19 safety safety NN cord-007788-09t52zix 743 20 evaluation evaluation NN cord-007788-09t52zix 743 21 of of IN cord-007788-09t52zix 743 22 defibrotide defibrotide NNP cord-007788-09t52zix 743 23 Surviving Surviving NNP cord-007788-09t52zix 743 24 sepsis sepsis NN cord-007788-09t52zix 743 25 campaign campaign NN cord-007788-09t52zix 743 26 : : : cord-007788-09t52zix 743 27 international international NNP cord-007788-09t52zix 743 28 guidelines guideline NNS cord-007788-09t52zix 743 29 for for IN cord-007788-09t52zix 743 30 management management NN cord-007788-09t52zix 743 31 of of IN cord-007788-09t52zix 743 32 sepsis sepsis NN cord-007788-09t52zix 743 33 and and CC cord-007788-09t52zix 743 34 septic septic JJ cord-007788-09t52zix 743 35 shock shock NN cord-007788-09t52zix 743 36 : : : cord-007788-09t52zix 744 1 2016 2016 CD cord-007788-09t52zix 744 2 Hematopoietic Hematopoietic NNP cord-007788-09t52zix 744 3 cell cell NN cord-007788-09t52zix 744 4 transplantationassociated transplantationassociated NNP cord-007788-09t52zix 744 5 thrombotic thrombotic JJ cord-007788-09t52zix 744 6 microangiopathy microangiopathy NNP cord-007788-09t52zix 744 7 : : : cord-007788-09t52zix 744 8 a a DT cord-007788-09t52zix 744 9 review review NN cord-007788-09t52zix 744 10 of of IN cord-007788-09t52zix 744 11 pathophysiology pathophysiology NN cord-007788-09t52zix 744 12 , , , cord-007788-09t52zix 744 13 diagnosis diagnosis NN cord-007788-09t52zix 744 14 , , , cord-007788-09t52zix 744 15 and and CC cord-007788-09t52zix 744 16 treatment treatment NN cord-007788-09t52zix 744 17 Chapter chapter NN cord-007788-09t52zix 744 18 12 12 CD cord-007788-09t52zix 744 19 : : : cord-007788-09t52zix 745 1 Infections infection NNS cord-007788-09t52zix 745 2 after after IN cord-007788-09t52zix 745 3 HSCT HSCT NNP cord-007788-09t52zix 745 4 . . . cord-007788-09t52zix 746 1 In in IN cord-007788-09t52zix 746 2 : : : cord-007788-09t52zix 746 3 EBMT EBMT NNP cord-007788-09t52zix 746 4 - - HYPH cord-007788-09t52zix 746 5 ESH ESH NNP cord-007788-09t52zix 746 6 handbook handbook NN cord-007788-09t52zix 746 7 Royal Royal NNP cord-007788-09t52zix 746 8 College College NNP cord-007788-09t52zix 746 9 of of IN cord-007788-09t52zix 746 10 Physicians Physicians NNPS cord-007788-09t52zix 746 11 . . . cord-007788-09t52zix 747 1 National National NNP cord-007788-09t52zix 747 2 Early Early NNP cord-007788-09t52zix 747 3 Warning Warning NNP cord-007788-09t52zix 747 4 Score Score NNP cord-007788-09t52zix 747 5 ( ( -LRB- cord-007788-09t52zix 747 6 NEWS NEWS NNP cord-007788-09t52zix 747 7 ) ) -RRB- cord-007788-09t52zix 747 8 standardising standardise VBG cord-007788-09t52zix 747 9 the the DT cord-007788-09t52zix 747 10 assessment assessment NN cord-007788-09t52zix 747 11 of of IN cord-007788-09t52zix 747 12 acuteillness acuteillness JJ cord-007788-09t52zix 747 13 severity severity NN cord-007788-09t52zix 747 14 in in IN cord-007788-09t52zix 747 15 the the DT cord-007788-09t52zix 747 16 NHS NHS NNP cord-007788-09t52zix 747 17 Clinical Clinical NNP cord-007788-09t52zix 747 18 practice practice NN cord-007788-09t52zix 747 19 guidelines guideline NNS cord-007788-09t52zix 747 20 for for IN cord-007788-09t52zix 747 21 the the DT cord-007788-09t52zix 747 22 prevention prevention NN cord-007788-09t52zix 747 23 and and CC cord-007788-09t52zix 747 24 treatment treatment NN cord-007788-09t52zix 747 25 of of IN cord-007788-09t52zix 747 26 cancer cancer NN cord-007788-09t52zix 747 27 therapy therapy NN cord-007788-09t52zix 747 28 -induced -induce VBN cord-007788-09t52zix 747 29 oral oral JJ cord-007788-09t52zix 747 30 and and CC cord-007788-09t52zix 747 31 gastrointestinal gastrointestinal JJ cord-007788-09t52zix 747 32 Mucositis Mucositis NNP cord-007788-09t52zix 747 33 Diagnostic diagnostic JJ cord-007788-09t52zix 747 34 criteria criterion NNS cord-007788-09t52zix 747 35 for for IN cord-007788-09t52zix 747 36 hematopoietic hematopoietic JJ cord-007788-09t52zix 747 37 stem stem NN cord-007788-09t52zix 747 38 cell cell NN cord-007788-09t52zix 747 39 transplant transplant NN cord-007788-09t52zix 747 40 - - HYPH cord-007788-09t52zix 747 41 associated associate VBN cord-007788-09t52zix 747 42 microangiopathy microangiopathy NNP cord-007788-09t52zix 747 43 : : : cord-007788-09t52zix 748 1 results result NNS cord-007788-09t52zix 748 2 of of IN cord-007788-09t52zix 748 3 a a DT cord-007788-09t52zix 748 4 consensus consensus NN cord-007788-09t52zix 748 5 process process NN cord-007788-09t52zix 748 6 by by IN cord-007788-09t52zix 748 7 an an DT cord-007788-09t52zix 748 8 international international JJ cord-007788-09t52zix 748 9 working working NN cord-007788-09t52zix 748 10 group group NN cord-007788-09t52zix 748 11 An an DT cord-007788-09t52zix 748 12 overview overview NN cord-007788-09t52zix 748 13 of of IN cord-007788-09t52zix 748 14 hematopoietic hematopoietic JJ cord-007788-09t52zix 748 15 stem stem NN cord-007788-09t52zix 748 16 cell cell NN cord-007788-09t52zix 748 17 transplantation transplantation NN cord-007788-09t52zix 748 18 related relate VBN cord-007788-09t52zix 748 19 thrombotic thrombotic JJ cord-007788-09t52zix 748 20 complications complication NNS cord-007788-09t52zix 748 21 Flossing floss VBG cord-007788-09t52zix 748 22 for for IN cord-007788-09t52zix 748 23 the the DT cord-007788-09t52zix 748 24 management management NN cord-007788-09t52zix 748 25 of of IN cord-007788-09t52zix 748 26 periodontal periodontal JJ cord-007788-09t52zix 748 27 diseases disease NNS cord-007788-09t52zix 748 28 and and CC cord-007788-09t52zix 748 29 dental dental JJ cord-007788-09t52zix 748 30 caries carie NNS cord-007788-09t52zix 748 31 in in IN cord-007788-09t52zix 748 32 adults adult NNS cord-007788-09t52zix 749 1 Clinical clinical JJ cord-007788-09t52zix 749 2 effectiveness effectiveness NN cord-007788-09t52zix 749 3 of of IN cord-007788-09t52zix 749 4 hyperbaric hyperbaric NN cord-007788-09t52zix 749 5 oxygen oxygen NN cord-007788-09t52zix 749 6 therapy therapy NN cord-007788-09t52zix 749 7 for for IN cord-007788-09t52zix 749 8 BK BK NNP cord-007788-09t52zix 749 9 - - HYPH cord-007788-09t52zix 749 10 virus virus NN cord-007788-09t52zix 749 11 - - HYPH cord-007788-09t52zix 749 12 associated associate VBN cord-007788-09t52zix 749 13 hemorrhagic hemorrhagic JJ cord-007788-09t52zix 749 14 cystitis cystitis NN cord-007788-09t52zix 749 15 after after IN cord-007788-09t52zix 749 16 allogeneic allogeneic NN cord-007788-09t52zix 749 17 bone bone NN cord-007788-09t52zix 749 18 marrow marrow NN cord-007788-09t52zix 749 19 transplantation transplantation NN cord-007788-09t52zix 749 20 Severe severe JJ cord-007788-09t52zix 749 21 sepsis sepsis NN cord-007788-09t52zix 749 22 and and CC cord-007788-09t52zix 749 23 septic septic JJ cord-007788-09t52zix 749 24 shock shock NN cord-007788-09t52zix 749 25 management management NN cord-007788-09t52zix 749 26 and and CC cord-007788-09t52zix 749 27 performance performance NN cord-007788-09t52zix 749 28 improvement improvement NN cord-007788-09t52zix 750 1 The the DT cord-007788-09t52zix 750 2 third third JJ cord-007788-09t52zix 750 3 international international JJ cord-007788-09t52zix 750 4 consensus consensus NN cord-007788-09t52zix 750 5 definitions definition NNS cord-007788-09t52zix 750 6 for for IN cord-007788-09t52zix 750 7 sepsis sepsis NN cord-007788-09t52zix 750 8 and and CC cord-007788-09t52zix 750 9 septic septic JJ cord-007788-09t52zix 750 10 shock shock NN cord-007788-09t52zix 750 11 ( ( -LRB- cord-007788-09t52zix 751 1 Sepsis-3 Sepsis-3 NNP cord-007788-09t52zix 751 2 ) ) -RRB- cord-007788-09t52zix 752 1 The the DT cord-007788-09t52zix 752 2 spectrum spectrum NN cord-007788-09t52zix 752 3 of of IN cord-007788-09t52zix 752 4 non non JJ cord-007788-09t52zix 752 5 - - JJ cord-007788-09t52zix 752 6 infectious infectious JJ cord-007788-09t52zix 752 7 pulmonary pulmonary JJ cord-007788-09t52zix 752 8 complications complication NNS cord-007788-09t52zix 752 9 following follow VBG cord-007788-09t52zix 752 10 hematopoietic hematopoietic JJ cord-007788-09t52zix 752 11 stem stem NN cord-007788-09t52zix 752 12 cell cell NN cord-007788-09t52zix 752 13 transplantation transplantation NN cord-007788-09t52zix 752 14 Engraftment Engraftment NNP cord-007788-09t52zix 752 15 syndrome syndrome NN cord-007788-09t52zix 752 16 following follow VBG cord-007788-09t52zix 752 17 autologous autologous JJ cord-007788-09t52zix 752 18 hematopoietic hematopoietic JJ cord-007788-09t52zix 752 19 stem stem NN cord-007788-09t52zix 752 20 cell cell NN cord-007788-09t52zix 752 21 transplantation transplantation NN cord-007788-09t52zix 752 22 Programme Programme NNP cord-007788-09t52zix 752 23 Group Group NNP cord-007788-09t52zix 752 24 Sepsis Sepsis NNP cord-007788-09t52zix 752 25 . . . cord-007788-09t52zix 753 1 Care care VB cord-007788-09t52zix 753 2 Program Program NNP cord-007788-09t52zix 753 3 Severe severe JJ cord-007788-09t52zix 753 4 Sepsis sepsis NN cord-007788-09t52zix 753 5 and and CC cord-007788-09t52zix 753 6 Septic Septic NNP cord-007788-09t52zix 753 7 Shock shock NN cord-007788-09t52zix 754 1 -Early -early RB cord-007788-09t52zix 754 2 identification identification NN cord-007788-09t52zix 754 3 and and CC cord-007788-09t52zix 754 4 initial initial JJ cord-007788-09t52zix 754 5 intervention intervention NN cord-007788-09t52zix 754 6 [ [ -LRB- cord-007788-09t52zix 754 7 För För NNP cord-007788-09t52zix 754 8 Svenska Svenska NNP cord-007788-09t52zix 754 9 Infektionsläkarföreningen Infektionsläkarföreningen NNP cord-007788-09t52zix 754 10 " " `` cord-007788-09t52zix 754 11 Pro pro JJ cord-007788-09t52zix 754 12 Sepsis sepsis NN cord-007788-09t52zix 754 13 " " '' cord-007788-09t52zix 754 14 Programgrupp Programgrupp NNP cord-007788-09t52zix 754 15 Sepsis sepsis NN cord-007788-09t52zix 754 16 . . . cord-007788-09t52zix 755 1 Vårdprogram Vårdprogram NNP cord-007788-09t52zix 755 2 svår svår NNP cord-007788-09t52zix 755 3 sepsis sepsis NNP cord-007788-09t52zix 755 4 och och NNP cord-007788-09t52zix 755 5 septisk septisk NNP cord-007788-09t52zix 755 6 chocktidig chocktidig NNP cord-007788-09t52zix 755 7 identifiering identifiering NNP cord-007788-09t52zix 755 8 och och NNP cord-007788-09t52zix 755 9 initial initial JJ cord-007788-09t52zix 755 10 handläggning handläggning NNP cord-007788-09t52zix 755 11 Engraftment Engraftment NNP cord-007788-09t52zix 755 12 syndrome syndrome NN cord-007788-09t52zix 755 13 in in IN cord-007788-09t52zix 755 14 hematopoietic hematopoietic JJ cord-007788-09t52zix 755 15 stem stem NN cord-007788-09t52zix 755 16 cell cell NN cord-007788-09t52zix 755 17 transplantations transplantation NNS cord-007788-09t52zix 755 18 Immune immune VBP cord-007788-09t52zix 755 19 reconstitution reconstitution NN cord-007788-09t52zix 755 20 after after IN cord-007788-09t52zix 755 21 allogeneic allogeneic NN cord-007788-09t52zix 755 22 HSCT HSCT NNP cord-007788-09t52zix 755 23 . . . cord-007788-09t52zix 756 1 In in IN cord-007788-09t52zix 756 2 : : : cord-007788-09t52zix 756 3 EBMT EBMT NNP cord-007788-09t52zix 756 4 - - HYPH cord-007788-09t52zix 756 5 ESH ESH NNP cord-007788-09t52zix 756 6 handbook handbook NN cord-007788-09t52zix 756 7 on on IN cord-007788-09t52zix 756 8 haematopoietic haematopoietic JJ cord-007788-09t52zix 756 9 stem stem NN cord-007788-09t52zix 756 10 cell cell NN cord-007788-09t52zix 756 11 transplantation transplantation NN cord-007788-09t52zix 757 1 Possible possible JJ cord-007788-09t52zix 757 2 antiviral antiviral JJ cord-007788-09t52zix 757 3 effect effect NN cord-007788-09t52zix 757 4 of of IN cord-007788-09t52zix 757 5 ciprofloxacin ciprofloxacin NN cord-007788-09t52zix 757 6 treatment treatment NN cord-007788-09t52zix 757 7 on on IN cord-007788-09t52zix 757 8 polyomavirus polyomavirus NNP cord-007788-09t52zix 757 9 BK BK NNP cord-007788-09t52zix 757 10 replication replication NN cord-007788-09t52zix 757 11 and and CC cord-007788-09t52zix 757 12 analysis analysis NN cord-007788-09t52zix 757 13 of of IN cord-007788-09t52zix 757 14 non non JJ cord-007788-09t52zix 757 15 - - JJ cord-007788-09t52zix 757 16 coding coding JJ cord-007788-09t52zix 757 17 control control NN cord-007788-09t52zix 757 18 region region NN cord-007788-09t52zix 757 19 sequences sequence NNS cord-007788-09t52zix 757 20 Veno Veno NNP cord-007788-09t52zix 757 21 Occlusive Occlusive NNP cord-007788-09t52zix 757 22 Disease Disease NNP cord-007788-09t52zix 757 23 ( ( -LRB- cord-007788-09t52zix 757 24 VOD VOD NNP cord-007788-09t52zix 757 25 ) ) -RRB- cord-007788-09t52zix 757 26 Learning Learning NNP cord-007788-09t52zix 757 27 Programme Programme NNP cord-007788-09t52zix 757 28 Management Management NNP cord-007788-09t52zix 757 29 of of IN cord-007788-09t52zix 757 30 veno veno NNP cord-007788-09t52zix 757 31 - - HYPH cord-007788-09t52zix 757 32 occlusive occlusive JJ cord-007788-09t52zix 757 33 disease disease NN cord-007788-09t52zix 757 34 : : : cord-007788-09t52zix 757 35 the the DT cord-007788-09t52zix 757 36 multidisciplinary multidisciplinary JJ cord-007788-09t52zix 757 37 approach approach NN cord-007788-09t52zix 757 38 to to TO cord-007788-09t52zix 757 39 care care VB cord-007788-09t52zix 757 40 Palliative Palliative NNP cord-007788-09t52zix 757 41 adult adult NN cord-007788-09t52zix 757 42 network network NN cord-007788-09t52zix 757 43 guidelines guideline NNS cord-007788-09t52zix 757 44 double double JJ cord-007788-09t52zix 757 45 - - HYPH cord-007788-09t52zix 757 46 blind blind JJ cord-007788-09t52zix 757 47 placebocontrolled placebocontrolled JJ cord-007788-09t52zix 757 48 trial trial NN cord-007788-09t52zix 757 49 of of IN cord-007788-09t52zix 757 50 soluble soluble JJ cord-007788-09t52zix 757 51 tumor tumor NN cord-007788-09t52zix 757 52 necrosis necrosis NN cord-007788-09t52zix 757 53 factor factor NN cord-007788-09t52zix 757 54 receptor receptor NN cord-007788-09t52zix 757 55 : : : cord-007788-09t52zix 757 56 Enbrel Enbrel NNP cord-007788-09t52zix 757 57 ( ( -LRB- cord-007788-09t52zix 757 58 Etanercept Etanercept NNP cord-007788-09t52zix 757 59 ) ) -RRB- cord-007788-09t52zix 757 60 for for IN cord-007788-09t52zix 757 61 the the DT cord-007788-09t52zix 757 62 treatment treatment NN cord-007788-09t52zix 757 63 of of IN cord-007788-09t52zix 757 64 idiopathic idiopathic JJ cord-007788-09t52zix 757 65 pneumonia pneumonia NN cord-007788-09t52zix 757 66 syndrome syndrome NN cord-007788-09t52zix 757 67 after after IN cord-007788-09t52zix 757 68 allogeneic allogeneic NN cord-007788-09t52zix 757 69 stem stem NN cord-007788-09t52zix 757 70 cell cell NN cord-007788-09t52zix 757 71 transplantation transplantation NN cord-007788-09t52zix 757 72 : : : cord-007788-09t52zix 757 73 blood blood NN cord-007788-09t52zix 757 74 and and CC cord-007788-09t52zix 757 75 marrow marrow NN cord-007788-09t52zix 757 76 transplant transplant NN cord-007788-09t52zix 757 77 clinical clinical JJ cord-007788-09t52zix 757 78 trials trial NNS cord-007788-09t52zix 757 79 network network NN cord-007788-09t52zix 757 80 protocol protocol NN cord-007788-09t52zix 757 81 Brain Brain NNP cord-007788-09t52zix 757 82 teaser teaser NN cord-007788-09t52zix 757 83 : : : cord-007788-09t52zix 757 84 encephalopathy encephalopathy NN cord-007788-09t52zix 757 85 after after IN cord-007788-09t52zix 757 86 stem stem NN cord-007788-09t52zix 757 87 cell cell NN cord-007788-09t52zix 757 88 transplantation transplantation NN cord-007788-09t52zix 757 89 Incidence incidence NN cord-007788-09t52zix 757 90 , , , cord-007788-09t52zix 757 91 risks risk NNS cord-007788-09t52zix 757 92 , , , cord-007788-09t52zix 757 93 and and CC cord-007788-09t52zix 757 94 outcome outcome NN cord-007788-09t52zix 757 95 of of IN cord-007788-09t52zix 757 96 idiopathic idiopathic JJ cord-007788-09t52zix 757 97 pneumonia pneumonia NN cord-007788-09t52zix 757 98 syndrome syndrome NN cord-007788-09t52zix 757 99 early early RB cord-007788-09t52zix 757 100 after after IN cord-007788-09t52zix 757 101 allogeneic allogeneic JJ cord-007788-09t52zix 757 102 hematopoietic hematopoietic JJ cord-007788-09t52zix 757 103 stem stem NN cord-007788-09t52zix 757 104 cell cell NN cord-007788-09t52zix 757 105 transplantation transplantation NN cord-007788-09t52zix 757 106 Acknowledgement Acknowledgement NNP cord-007788-09t52zix 757 107 European European NNP cord-007788-09t52zix 757 108 Oral Oral NNP cord-007788-09t52zix 757 109 Care Care NNP cord-007788-09t52zix 757 110 in in IN cord-007788-09t52zix 757 111 Cancer Cancer NNP cord-007788-09t52zix 757 112 Group Group NNP cord-007788-09t52zix 757 113 ( ( -LRB- cord-007788-09t52zix 757 114 EOCC EOCC NNP cord-007788-09t52zix 757 115 ) ) -RRB- cord-007788-09t52zix 757 116 . . .