id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-016743-k5plq0ja	Mohammed, Yousuf H.	Efficacy, Safety and Targets in Topical and Transdermal Active and Excipient Delivery	2017-01-25		.txt	text/plain	10095	524	44	(2005) assessed the safety of five sunscreens by determining their in vitro toxicity to human keratinocytes in culture then estimated the equivalent concentration to inhibit 50 % of cells in viable epidermis, after adjustment for the differences in protein binding in the two media ( Fig. 23.1 ). Our own work supports this, suggesting that, firstly, uptake by the blood in the dermal capillaries located just below the viable epidermis is likely to be the rate limiting determinant of clearance in vivo and secondly, carriage of topical non-steroidal anti-inflammatory drugs (NSAIDS) to deeper tissues below that application site is also dependent on blood flow for highly plasma protein-bound drugs (Dancik et al. Hence, this report emphasizes the need to relate the in vivo dosimetry of sensitizers that penetrate into the viable epidermis via the stratum corneum of human skin to the concentrations used in in vitro applications.	./cache/cord-016743-k5plq0ja.txt	./txt/cord-016743-k5plq0ja.txt