id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-022226-qxp0gfp3	Meager, Anthony	Interferons Alpha, Beta, and Omega	2007-09-02		.txt	text/plain	16375	813	46	PRDI and PRDIII act as binding sites for a nuclear transcription factor, designated "interferon regulatory factor-l" (IRF-1) , whose expression is transiently increased by virus infection and which appears to mediate the activation of transcription of the IFNB gene (Fujita et al., 1988; Harada et al., 1989; Xanthoudakis et al., 1989) . For example, the IFN-inducible Mx proteins block the replication of influenza virus, probably by inhibiting the nuclear phase of viral transcription (mouse cells) or later cytoplasmic phases (human cells), without affecting the replication of many other viruses (Staeheli, 1990; Mel6n et al., 1992; Ronni et al., 1993) . A number of other negative regulatory factors, including IRF2 (Harada et al., 1989) and the ISGF2 (IRF1)/ISGF3yrelated "human interferon consensus sequence binding protein" (ICSBP) (Weisz et al., 1992; Bovolenta et al., 1994) , which also bind to ISRE, are also probably involved in the regulation of transcription of IFN-inducible genes.	./cache/cord-022226-qxp0gfp3.txt	./txt/cord-022226-qxp0gfp3.txt