id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-030748-780dcjo1	Sahu, Sounak	Translating embryogenesis to generate organoids: novel approaches to personalized medicine	2020-08-21		.txt	text/plain	10011	543	38	Recent innovations in generating embryo-like structures (including blastoids and gastruloids) from PSCs have advanced the experimental accessibility to understand embryogenesis with immense potential to model human development. Organoids can be generated from embryonic stem cells (ESCs) or induced pluripotent stem cells (iPSCs) derived from patients, that can be used for studying organ development, modeling human diseases, and for autologous organ replacement. While many reviews have addressed the principles of bioengineering to develop 3D cell culture models and protocols to generate organoids from adult tissues, here we present insights to the state-of-the-art knowledge on the self-organization property of PSCs to generate embryo-like structures and organoids, its advantage to model human diseases and challenges for optimum clinical management.	./cache/cord-030748-780dcjo1.txt	./txt/cord-030748-780dcjo1.txt