id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252810-rko3e5va	Basil, Maria C.	The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future	2020-04-02		.txt	text/plain	14828	678	40	Recent transcriptional interrogation of the distal epithelium in IPF identified activation of cell stress and senescence pathways, and murine modeling of AT2 cell dysfunction from expression of either mutant SFTPC, loss of telomere function, and increased mechanical tension have provided in vivo proof of concept that disruption of AT2 cell homeostasis is a driver of lung fibrosis (Katzen et An emerging hypothesis of IPF pathogenesis is that the dysfunctional AT2 cell loses its facultative progenitor capacity creating a regenerative void for lung repair. Importantly, these cellular trajectory models require experimental validation either in the form of cell-type-specific genetic lineage tracing in mice or the use of cellular barcoding strategies in non-murine systems such as was performed in a recent study to predict the differentiation of lung epithelial progenitors from pluripotent stem cells (Hurley et al., 2020) .	./cache/cord-252810-rko3e5va.txt	./txt/cord-252810-rko3e5va.txt