id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-305318-cont592g	Lancaster, Madeline A.	Disease modelling in human organoids	2019-07-01		.txt	text/plain	10865	484	39	Thus, more recent approaches have focused on in vitro models derived from stem cells, which allow for a broader array of tissue identities, long-term expansion, better genomic integrity and improved modelling of healthy biology. established the first adult murine-tissue-derived liver organoid culture that sustains the long-term expansion of liver cells in vitro (Huch et al., 2013b) . Addition of an activator of cyclic adenosyl monophosphate (cAMP) signalling and inhibition of TGFβ signalling adapted this culture system to the expansion of adult human liver cells as self-renewing organoids that recapitulate some function of ex vivo liver tissue . (2014) was instrumental in characterizing the early stages of metanephric kidney development, particularly the formation of metanephric mesenchyme (MM), then applying the identified signalling factors to direct differentiation of mouse and human PSCs specifically towards MM cells that could form 3D structures when cocultured with mouse tissues.	./cache/cord-305318-cont592g.txt	./txt/cord-305318-cont592g.txt