id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342054-1u2fkwx3	Funaro, Ada	Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells	2008-11-12		.txt	text/plain	5484	277	42	The available therapeutic armamentarium (e.g. HCMV hyperimmune globulins or antivirals) is associated with severe side effects and the emergence of drug-resistant strains; therefore, neutralizing human mAb may be a decisive alternative in the prevention of primary and re-activated HCMV infections in these patients. The strengths of this approach are: i) it allows the selection of human monoclonal IgG to a variety of antigens, from a small sample of fresh or frozen peripheral blood, ii) it is rapid, iii) screening can be performed using a variety of assays, including functional assays, iv) the mAbs of interest can be easily produced from the original clone as recombinant proteins suitable for clinical applications, and v) the generation of IgGsecreting polyclonal populations can be considered as a library of antibody-secreting cells that can be used to select mAbs with specificities not considered when cells were immortalized.	./cache/cord-342054-1u2fkwx3.txt	./txt/cord-342054-1u2fkwx3.txt