id sid tid token lemma pos cord-002728-6oyw5sqv 1 1 key key JJ cord-002728-6oyw5sqv 1 2 : : : cord-002728-6oyw5sqv 1 3 cord-002728 cord-002728 NNP cord-002728-6oyw5sqv 1 4 - - HYPH cord-002728-6oyw5sqv 1 5 6oyw5sqv 6oyw5sqv CD cord-002728-6oyw5sqv 1 6 authors author NNS cord-002728-6oyw5sqv 1 7 : : : cord-002728-6oyw5sqv 1 8 Carding Carding NNP cord-002728-6oyw5sqv 1 9 , , , cord-002728-6oyw5sqv 1 10 S. S. NNP cord-002728-6oyw5sqv 1 11 R. R. NNP cord-002728-6oyw5sqv 1 12 ; ; : cord-002728-6oyw5sqv 1 13 Davis Davis NNP cord-002728-6oyw5sqv 1 14 , , , cord-002728-6oyw5sqv 1 15 N. N. NNP cord-002728-6oyw5sqv 1 16 ; ; : cord-002728-6oyw5sqv 1 17 Hoyles Hoyles NNP cord-002728-6oyw5sqv 1 18 , , , cord-002728-6oyw5sqv 1 19 L. L. NNP cord-002728-6oyw5sqv 1 20 title title NN cord-002728-6oyw5sqv 1 21 : : : cord-002728-6oyw5sqv 2 1 Review Review NNP cord-002728-6oyw5sqv 2 2 article article NN cord-002728-6oyw5sqv 2 3 : : : cord-002728-6oyw5sqv 2 4 the the DT cord-002728-6oyw5sqv 2 5 human human JJ cord-002728-6oyw5sqv 2 6 intestinal intestinal JJ cord-002728-6oyw5sqv 2 7 virome virome NN cord-002728-6oyw5sqv 2 8 in in IN cord-002728-6oyw5sqv 2 9 health health NN cord-002728-6oyw5sqv 2 10 and and CC cord-002728-6oyw5sqv 2 11 disease disease NN cord-002728-6oyw5sqv 2 12 date date NN cord-002728-6oyw5sqv 2 13 : : : cord-002728-6oyw5sqv 2 14 2017 2017 CD cord-002728-6oyw5sqv 2 15 - - HYPH cord-002728-6oyw5sqv 2 16 09 09 CD cord-002728-6oyw5sqv 2 17 - - HYPH cord-002728-6oyw5sqv 2 18 04 04 CD cord-002728-6oyw5sqv 2 19 journal journal NN cord-002728-6oyw5sqv 2 20 : : : cord-002728-6oyw5sqv 3 1 Aliment Aliment NNP cord-002728-6oyw5sqv 3 2 Pharmacol Pharmacol NNP cord-002728-6oyw5sqv 4 1 Ther ther JJ cord-002728-6oyw5sqv 4 2 DOI DOI NNP cord-002728-6oyw5sqv 4 3 : : : cord-002728-6oyw5sqv 5 1 10.1111 10.1111 CD cord-002728-6oyw5sqv 5 2 / / SYM cord-002728-6oyw5sqv 5 3 apt.14280 apt.14280 NNP cord-002728-6oyw5sqv 5 4 sha sha NNP cord-002728-6oyw5sqv 5 5 : : : cord-002728-6oyw5sqv 5 6 16406822b5673734cefa5a986007b6fff662c7b5 16406822b5673734cefa5a986007b6fff662c7b5 CD cord-002728-6oyw5sqv 5 7 doc_id doc_id CD cord-002728-6oyw5sqv 5 8 : : : cord-002728-6oyw5sqv 5 9 2728 2728 CD cord-002728-6oyw5sqv 5 10 cord_uid cord_uid NNS cord-002728-6oyw5sqv 5 11 : : : cord-002728-6oyw5sqv 5 12 6oyw5sqv 6oyw5sqv . cord-002728-6oyw5sqv 6 1 BACKGROUND background NN cord-002728-6oyw5sqv 6 2 : : : cord-002728-6oyw5sqv 7 1 The the DT cord-002728-6oyw5sqv 7 2 human human JJ cord-002728-6oyw5sqv 7 3 virome virome NN cord-002728-6oyw5sqv 7 4 consists consist VBZ cord-002728-6oyw5sqv 7 5 of of IN cord-002728-6oyw5sqv 7 6 animal‐cell animal‐cell NNP cord-002728-6oyw5sqv 7 7 viruses virus NNS cord-002728-6oyw5sqv 7 8 causing cause VBG cord-002728-6oyw5sqv 7 9 transient transient JJ cord-002728-6oyw5sqv 7 10 infections infection NNS cord-002728-6oyw5sqv 7 11 , , , cord-002728-6oyw5sqv 8 1 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 8 2 ( ( -LRB- cord-002728-6oyw5sqv 8 3 phage phage NN cord-002728-6oyw5sqv 8 4 ) ) -RRB- cord-002728-6oyw5sqv 8 5 predators predator NNS cord-002728-6oyw5sqv 8 6 of of IN cord-002728-6oyw5sqv 8 7 bacteria bacteria NNS cord-002728-6oyw5sqv 8 8 and and CC cord-002728-6oyw5sqv 8 9 archaea archaea NNS cord-002728-6oyw5sqv 8 10 , , , cord-002728-6oyw5sqv 8 11 endogenous endogenous JJ cord-002728-6oyw5sqv 8 12 retroviruses retrovirus NNS cord-002728-6oyw5sqv 8 13 and and CC cord-002728-6oyw5sqv 8 14 viruses virus NNS cord-002728-6oyw5sqv 8 15 causing cause VBG cord-002728-6oyw5sqv 8 16 persistent persistent JJ cord-002728-6oyw5sqv 8 17 and and CC cord-002728-6oyw5sqv 8 18 latent latent JJ cord-002728-6oyw5sqv 8 19 infections infection NNS cord-002728-6oyw5sqv 8 20 . . . cord-002728-6oyw5sqv 9 1 High‐throughput High‐throughput NNP cord-002728-6oyw5sqv 9 2 , , , cord-002728-6oyw5sqv 9 3 inexpensive inexpensive JJ cord-002728-6oyw5sqv 9 4 , , , cord-002728-6oyw5sqv 9 5 sensitive sensitive JJ cord-002728-6oyw5sqv 9 6 sequencing sequencing NN cord-002728-6oyw5sqv 9 7 methods method NNS cord-002728-6oyw5sqv 9 8 and and CC cord-002728-6oyw5sqv 9 9 metagenomics metagenomic NNS cord-002728-6oyw5sqv 9 10 now now RB cord-002728-6oyw5sqv 9 11 make make VBP cord-002728-6oyw5sqv 9 12 it -PRON- PRP cord-002728-6oyw5sqv 9 13 possible possible JJ cord-002728-6oyw5sqv 9 14 to to TO cord-002728-6oyw5sqv 9 15 study study VB cord-002728-6oyw5sqv 9 16 the the DT cord-002728-6oyw5sqv 9 17 contribution contribution NN cord-002728-6oyw5sqv 9 18 dsDNA dsdna RB cord-002728-6oyw5sqv 9 19 , , , cord-002728-6oyw5sqv 9 20 ssDNA ssdna JJ cord-002728-6oyw5sqv 9 21 and and CC cord-002728-6oyw5sqv 9 22 RNA RNA NNP cord-002728-6oyw5sqv 9 23 virus‐like virus‐like NNP cord-002728-6oyw5sqv 9 24 particles particle NNS cord-002728-6oyw5sqv 9 25 make make VBP cord-002728-6oyw5sqv 9 26 to to IN cord-002728-6oyw5sqv 9 27 the the DT cord-002728-6oyw5sqv 9 28 human human JJ cord-002728-6oyw5sqv 9 29 virome virome NN cord-002728-6oyw5sqv 9 30 , , , cord-002728-6oyw5sqv 9 31 and and CC cord-002728-6oyw5sqv 9 32 in in IN cord-002728-6oyw5sqv 9 33 particular particular JJ cord-002728-6oyw5sqv 9 34 the the DT cord-002728-6oyw5sqv 9 35 intestinal intestinal JJ cord-002728-6oyw5sqv 9 36 virome virome NN cord-002728-6oyw5sqv 9 37 . . . cord-002728-6oyw5sqv 10 1 AIM aim VB cord-002728-6oyw5sqv 10 2 : : : cord-002728-6oyw5sqv 11 1 To to TO cord-002728-6oyw5sqv 11 2 review review VB cord-002728-6oyw5sqv 11 3 and and CC cord-002728-6oyw5sqv 11 4 evaluate evaluate VB cord-002728-6oyw5sqv 11 5 the the DT cord-002728-6oyw5sqv 11 6 pioneering pioneering JJ cord-002728-6oyw5sqv 11 7 studies study NNS cord-002728-6oyw5sqv 11 8 that that WDT cord-002728-6oyw5sqv 11 9 have have VBP cord-002728-6oyw5sqv 11 10 attempted attempt VBN cord-002728-6oyw5sqv 11 11 to to TO cord-002728-6oyw5sqv 11 12 characterise characterise VB cord-002728-6oyw5sqv 11 13 the the DT cord-002728-6oyw5sqv 11 14 human human JJ cord-002728-6oyw5sqv 11 15 virome virome NN cord-002728-6oyw5sqv 11 16 and and CC cord-002728-6oyw5sqv 11 17 generated generate VBD cord-002728-6oyw5sqv 11 18 an an DT cord-002728-6oyw5sqv 11 19 increased increase VBN cord-002728-6oyw5sqv 11 20 interest interest NN cord-002728-6oyw5sqv 11 21 in in IN cord-002728-6oyw5sqv 11 22 understanding understand VBG cord-002728-6oyw5sqv 11 23 how how WRB cord-002728-6oyw5sqv 11 24 the the DT cord-002728-6oyw5sqv 11 25 intestinal intestinal JJ cord-002728-6oyw5sqv 11 26 virome virome NN cord-002728-6oyw5sqv 11 27 might may MD cord-002728-6oyw5sqv 11 28 contribute contribute VB cord-002728-6oyw5sqv 11 29 to to IN cord-002728-6oyw5sqv 11 30 maintaining maintain VBG cord-002728-6oyw5sqv 11 31 health health NN cord-002728-6oyw5sqv 11 32 , , , cord-002728-6oyw5sqv 11 33 and and CC cord-002728-6oyw5sqv 11 34 the the DT cord-002728-6oyw5sqv 11 35 pathogenesis pathogenesis NN cord-002728-6oyw5sqv 11 36 of of IN cord-002728-6oyw5sqv 11 37 chronic chronic JJ cord-002728-6oyw5sqv 11 38 diseases disease NNS cord-002728-6oyw5sqv 11 39 . . . cord-002728-6oyw5sqv 12 1 METHODS methods NN cord-002728-6oyw5sqv 12 2 : : : cord-002728-6oyw5sqv 13 1 Relevant relevant JJ cord-002728-6oyw5sqv 13 2 virome‐related virome‐related JJ cord-002728-6oyw5sqv 13 3 articles article NNS cord-002728-6oyw5sqv 13 4 were be VBD cord-002728-6oyw5sqv 13 5 selected select VBN cord-002728-6oyw5sqv 13 6 for for IN cord-002728-6oyw5sqv 13 7 review review NN cord-002728-6oyw5sqv 13 8 following follow VBG cord-002728-6oyw5sqv 13 9 extensive extensive JJ cord-002728-6oyw5sqv 13 10 language‐ language‐ NN cord-002728-6oyw5sqv 13 11 and and CC cord-002728-6oyw5sqv 13 12 date‐unrestricted date‐unrestricted JJ cord-002728-6oyw5sqv 13 13 , , , cord-002728-6oyw5sqv 13 14 electronic electronic JJ cord-002728-6oyw5sqv 13 15 searches search NNS cord-002728-6oyw5sqv 13 16 of of IN cord-002728-6oyw5sqv 13 17 the the DT cord-002728-6oyw5sqv 13 18 literature literature NN cord-002728-6oyw5sqv 13 19 . . . cord-002728-6oyw5sqv 14 1 RESULTS result NNS cord-002728-6oyw5sqv 14 2 : : : cord-002728-6oyw5sqv 15 1 The the DT cord-002728-6oyw5sqv 15 2 human human JJ cord-002728-6oyw5sqv 15 3 intestinal intestinal JJ cord-002728-6oyw5sqv 15 4 virome virome NN cord-002728-6oyw5sqv 15 5 is be VBZ cord-002728-6oyw5sqv 15 6 personalised personalised JJ cord-002728-6oyw5sqv 15 7 and and CC cord-002728-6oyw5sqv 15 8 stable stable JJ cord-002728-6oyw5sqv 15 9 , , , cord-002728-6oyw5sqv 15 10 and and CC cord-002728-6oyw5sqv 15 11 dominated dominate VBN cord-002728-6oyw5sqv 15 12 by by IN cord-002728-6oyw5sqv 15 13 phages phage NNS cord-002728-6oyw5sqv 15 14 . . . cord-002728-6oyw5sqv 16 1 It -PRON- PRP cord-002728-6oyw5sqv 16 2 develops develop VBZ cord-002728-6oyw5sqv 16 3 soon soon RB cord-002728-6oyw5sqv 16 4 after after IN cord-002728-6oyw5sqv 16 5 birth birth NN cord-002728-6oyw5sqv 16 6 in in IN cord-002728-6oyw5sqv 16 7 parallel parallel NN cord-002728-6oyw5sqv 16 8 with with IN cord-002728-6oyw5sqv 16 9 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 16 10 communities community NNS cord-002728-6oyw5sqv 16 11 of of IN cord-002728-6oyw5sqv 16 12 the the DT cord-002728-6oyw5sqv 16 13 microbiota microbiota NN cord-002728-6oyw5sqv 16 14 , , , cord-002728-6oyw5sqv 16 15 becoming become VBG cord-002728-6oyw5sqv 16 16 established establish VBN cord-002728-6oyw5sqv 16 17 during during IN cord-002728-6oyw5sqv 16 18 the the DT cord-002728-6oyw5sqv 16 19 first first JJ cord-002728-6oyw5sqv 16 20 few few JJ cord-002728-6oyw5sqv 16 21 years year NNS cord-002728-6oyw5sqv 16 22 of of IN cord-002728-6oyw5sqv 16 23 life life NN cord-002728-6oyw5sqv 16 24 . . . cord-002728-6oyw5sqv 17 1 By by IN cord-002728-6oyw5sqv 17 2 infecting infect VBG cord-002728-6oyw5sqv 17 3 specific specific JJ cord-002728-6oyw5sqv 17 4 populations population NNS cord-002728-6oyw5sqv 17 5 of of IN cord-002728-6oyw5sqv 17 6 bacteria bacteria NNS cord-002728-6oyw5sqv 17 7 , , , cord-002728-6oyw5sqv 17 8 phages phage NNS cord-002728-6oyw5sqv 17 9 can can MD cord-002728-6oyw5sqv 17 10 alter alter VB cord-002728-6oyw5sqv 17 11 microbiota microbiota NN cord-002728-6oyw5sqv 17 12 structure structure NN cord-002728-6oyw5sqv 17 13 by by IN cord-002728-6oyw5sqv 17 14 killing kill VBG cord-002728-6oyw5sqv 17 15 host host NN cord-002728-6oyw5sqv 17 16 cells cell NNS cord-002728-6oyw5sqv 17 17 or or CC cord-002728-6oyw5sqv 17 18 altering alter VBG cord-002728-6oyw5sqv 17 19 their -PRON- PRP$ cord-002728-6oyw5sqv 17 20 phenotype phenotype NN cord-002728-6oyw5sqv 17 21 , , , cord-002728-6oyw5sqv 17 22 enabling enable VBG cord-002728-6oyw5sqv 17 23 phages phage NNS cord-002728-6oyw5sqv 17 24 to to TO cord-002728-6oyw5sqv 17 25 contribute contribute VB cord-002728-6oyw5sqv 17 26 to to IN cord-002728-6oyw5sqv 17 27 maintaining maintain VBG cord-002728-6oyw5sqv 17 28 intestinal intestinal JJ cord-002728-6oyw5sqv 17 29 homeostasis homeostasis NN cord-002728-6oyw5sqv 17 30 or or CC cord-002728-6oyw5sqv 17 31 microbial microbial JJ cord-002728-6oyw5sqv 17 32 imbalance imbalance NN cord-002728-6oyw5sqv 17 33 ( ( -LRB- cord-002728-6oyw5sqv 17 34 dysbiosis dysbiosis NN cord-002728-6oyw5sqv 17 35 ) ) -RRB- cord-002728-6oyw5sqv 17 36 , , , cord-002728-6oyw5sqv 17 37 and and CC cord-002728-6oyw5sqv 17 38 the the DT cord-002728-6oyw5sqv 17 39 development development NN cord-002728-6oyw5sqv 17 40 of of IN cord-002728-6oyw5sqv 17 41 chronic chronic JJ cord-002728-6oyw5sqv 17 42 infectious infectious JJ cord-002728-6oyw5sqv 17 43 and and CC cord-002728-6oyw5sqv 17 44 autoimmune autoimmune JJ cord-002728-6oyw5sqv 17 45 diseases disease NNS cord-002728-6oyw5sqv 17 46 including include VBG cord-002728-6oyw5sqv 17 47 HIV HIV NNP cord-002728-6oyw5sqv 17 48 infection infection NN cord-002728-6oyw5sqv 17 49 and and CC cord-002728-6oyw5sqv 17 50 Crohn Crohn NNP cord-002728-6oyw5sqv 17 51 's 's POS cord-002728-6oyw5sqv 17 52 disease disease NN cord-002728-6oyw5sqv 17 53 , , , cord-002728-6oyw5sqv 17 54 respectively respectively RB cord-002728-6oyw5sqv 17 55 . . . cord-002728-6oyw5sqv 18 1 CONCLUSIONS conclusion NNS cord-002728-6oyw5sqv 18 2 : : : cord-002728-6oyw5sqv 19 1 Our -PRON- PRP$ cord-002728-6oyw5sqv 19 2 understanding understanding NN cord-002728-6oyw5sqv 19 3 of of IN cord-002728-6oyw5sqv 19 4 the the DT cord-002728-6oyw5sqv 19 5 intestinal intestinal JJ cord-002728-6oyw5sqv 19 6 virome virome NN cord-002728-6oyw5sqv 19 7 is be VBZ cord-002728-6oyw5sqv 19 8 fragmented fragmented JJ cord-002728-6oyw5sqv 19 9 and and CC cord-002728-6oyw5sqv 19 10 requires require VBZ cord-002728-6oyw5sqv 19 11 standardised standardised JJ cord-002728-6oyw5sqv 19 12 methods method NNS cord-002728-6oyw5sqv 19 13 for for IN cord-002728-6oyw5sqv 19 14 virus virus NN cord-002728-6oyw5sqv 19 15 isolation isolation NN cord-002728-6oyw5sqv 19 16 and and CC cord-002728-6oyw5sqv 19 17 sequencing sequencing NN cord-002728-6oyw5sqv 19 18 to to TO cord-002728-6oyw5sqv 19 19 provide provide VB cord-002728-6oyw5sqv 19 20 a a DT cord-002728-6oyw5sqv 19 21 more more RBR cord-002728-6oyw5sqv 19 22 complete complete JJ cord-002728-6oyw5sqv 19 23 picture picture NN cord-002728-6oyw5sqv 19 24 of of IN cord-002728-6oyw5sqv 19 25 the the DT cord-002728-6oyw5sqv 19 26 virome virome NN cord-002728-6oyw5sqv 19 27 , , , cord-002728-6oyw5sqv 19 28 which which WDT cord-002728-6oyw5sqv 19 29 is be VBZ cord-002728-6oyw5sqv 19 30 key key JJ cord-002728-6oyw5sqv 19 31 to to IN cord-002728-6oyw5sqv 19 32 explaining explain VBG cord-002728-6oyw5sqv 19 33 the the DT cord-002728-6oyw5sqv 19 34 basis basis NN cord-002728-6oyw5sqv 19 35 of of IN cord-002728-6oyw5sqv 19 36 virome‐disease virome‐disease JJ cord-002728-6oyw5sqv 19 37 associations association NNS cord-002728-6oyw5sqv 19 38 , , , cord-002728-6oyw5sqv 19 39 and and CC cord-002728-6oyw5sqv 19 40 how how WRB cord-002728-6oyw5sqv 19 41 enteric enteric JJ cord-002728-6oyw5sqv 19 42 viruses virus NNS cord-002728-6oyw5sqv 19 43 can can MD cord-002728-6oyw5sqv 19 44 contribute contribute VB cord-002728-6oyw5sqv 19 45 to to IN cord-002728-6oyw5sqv 19 46 disease disease NN cord-002728-6oyw5sqv 19 47 aetiologies aetiology NNS cord-002728-6oyw5sqv 19 48 and and CC cord-002728-6oyw5sqv 19 49 be be VB cord-002728-6oyw5sqv 19 50 rationalised rationalise VBN cord-002728-6oyw5sqv 19 51 as as IN cord-002728-6oyw5sqv 19 52 targets target NNS cord-002728-6oyw5sqv 19 53 for for IN cord-002728-6oyw5sqv 19 54 interventions intervention NNS cord-002728-6oyw5sqv 19 55 . . . cord-002728-6oyw5sqv 20 1 Viruses virus NNS cord-002728-6oyw5sqv 20 2 are be VBP cord-002728-6oyw5sqv 20 3 thought think VBN cord-002728-6oyw5sqv 20 4 to to TO cord-002728-6oyw5sqv 20 5 be be VB cord-002728-6oyw5sqv 20 6 the the DT cord-002728-6oyw5sqv 20 7 most most RBS cord-002728-6oyw5sqv 20 8 abundant abundant JJ cord-002728-6oyw5sqv 20 9 and and CC cord-002728-6oyw5sqv 20 10 diverse diverse JJ cord-002728-6oyw5sqv 20 11 entities entity NNS cord-002728-6oyw5sqv 20 12 on on IN cord-002728-6oyw5sqv 20 13 Earth Earth NNP cord-002728-6oyw5sqv 20 14 , , , cord-002728-6oyw5sqv 20 15 numbering number VBG cord-002728-6oyw5sqv 20 16 as as RB cord-002728-6oyw5sqv 20 17 many many JJ cord-002728-6oyw5sqv 20 18 as as IN cord-002728-6oyw5sqv 20 19 10 10 CD cord-002728-6oyw5sqv 20 20 31 31 CD cord-002728-6oyw5sqv 20 21 virus virus NN cord-002728-6oyw5sqv 20 22 - - HYPH cord-002728-6oyw5sqv 20 23 like like JJ cord-002728-6oyw5sqv 20 24 particles particle NNS cord-002728-6oyw5sqv 20 25 ( ( -LRB- cord-002728-6oyw5sqv 20 26 VLPs VLPs NNP cord-002728-6oyw5sqv 20 27 ) ) -RRB- cord-002728-6oyw5sqv 20 28 , , , cord-002728-6oyw5sqv 20 29 1 1 CD cord-002728-6oyw5sqv 20 30 though though IN cord-002728-6oyw5sqv 20 31 this this DT cord-002728-6oyw5sqv 20 32 paradigm paradigm NN cord-002728-6oyw5sqv 20 33 is be VBZ cord-002728-6oyw5sqv 20 34 likely likely JJ cord-002728-6oyw5sqv 20 35 to to TO cord-002728-6oyw5sqv 20 36 change change VB cord-002728-6oyw5sqv 20 37 in in IN cord-002728-6oyw5sqv 20 38 light light NN cord-002728-6oyw5sqv 20 39 of of IN cord-002728-6oyw5sqv 20 40 information information NN cord-002728-6oyw5sqv 20 41 from from IN cord-002728-6oyw5sqv 20 42 large large JJ cord-002728-6oyw5sqv 20 43 - - HYPH cord-002728-6oyw5sqv 20 44 scale scale NN cord-002728-6oyw5sqv 20 45 sequencing sequencing NN cord-002728-6oyw5sqv 20 46 surveys survey NNS cord-002728-6oyw5sqv 20 47 of of IN cord-002728-6oyw5sqv 20 48 marine marine JJ cord-002728-6oyw5sqv 20 49 environments environment NNS cord-002728-6oyw5sqv 20 50 and and CC cord-002728-6oyw5sqv 20 51 improved improve VBN cord-002728-6oyw5sqv 20 52 analytical analytical JJ cord-002728-6oyw5sqv 20 53 tools tool NNS cord-002728-6oyw5sqv 20 54 . . . cord-002728-6oyw5sqv 21 1 2 2 LS cord-002728-6oyw5sqv 22 1 With with IN cord-002728-6oyw5sqv 22 2 the the DT cord-002728-6oyw5sqv 22 3 advent advent NN cord-002728-6oyw5sqv 22 4 of of IN cord-002728-6oyw5sqv 22 5 new new JJ cord-002728-6oyw5sqv 22 6 , , , cord-002728-6oyw5sqv 22 7 sequence sequence NN cord-002728-6oyw5sqv 22 8 - - HYPH cord-002728-6oyw5sqv 22 9 based base VBN cord-002728-6oyw5sqv 22 10 technologies technology NNS cord-002728-6oyw5sqv 22 11 that that WDT cord-002728-6oyw5sqv 22 12 do do VBP cord-002728-6oyw5sqv 22 13 not not RB cord-002728-6oyw5sqv 22 14 rely rely VB cord-002728-6oyw5sqv 22 15 on on IN cord-002728-6oyw5sqv 22 16 the the DT cord-002728-6oyw5sqv 22 17 ability ability NN cord-002728-6oyw5sqv 22 18 to to TO cord-002728-6oyw5sqv 22 19 isolate isolate VB cord-002728-6oyw5sqv 22 20 viruses virus NNS cord-002728-6oyw5sqv 22 21 for for IN cord-002728-6oyw5sqv 22 22 their -PRON- PRP$ cord-002728-6oyw5sqv 22 23 identification identification NN cord-002728-6oyw5sqv 22 24 , , , cord-002728-6oyw5sqv 22 25 it -PRON- PRP cord-002728-6oyw5sqv 22 26 is be VBZ cord-002728-6oyw5sqv 22 27 now now RB cord-002728-6oyw5sqv 22 28 possible possible JJ cord-002728-6oyw5sqv 22 29 to to TO cord-002728-6oyw5sqv 22 30 define define VB cord-002728-6oyw5sqv 22 31 and and CC cord-002728-6oyw5sqv 22 32 characterise characterise VB cord-002728-6oyw5sqv 22 33 viruses virus NNS cord-002728-6oyw5sqv 22 34 in in IN cord-002728-6oyw5sqv 22 35 different different JJ cord-002728-6oyw5sqv 22 36 environmental environmental JJ cord-002728-6oyw5sqv 22 37 samples sample NNS cord-002728-6oyw5sqv 22 38 in in IN cord-002728-6oyw5sqv 22 39 greater great JJR cord-002728-6oyw5sqv 22 40 detail detail NN cord-002728-6oyw5sqv 22 41 than than IN cord-002728-6oyw5sqv 22 42 ever ever RB cord-002728-6oyw5sqv 22 43 before before RB cord-002728-6oyw5sqv 22 44 , , , cord-002728-6oyw5sqv 22 45 which which WDT cord-002728-6oyw5sqv 22 46 has have VBZ cord-002728-6oyw5sqv 22 47 resulted result VBN cord-002728-6oyw5sqv 22 48 in in IN cord-002728-6oyw5sqv 22 49 an an DT cord-002728-6oyw5sqv 22 50 increased increase VBN cord-002728-6oyw5sqv 22 51 interest interest NN cord-002728-6oyw5sqv 22 52 in in IN cord-002728-6oyw5sqv 22 53 the the DT cord-002728-6oyw5sqv 22 54 role role NN cord-002728-6oyw5sqv 23 1 the the DT cord-002728-6oyw5sqv 23 2 viral viral JJ cord-002728-6oyw5sqv 23 3 assemblage assemblage NN cord-002728-6oyw5sqv 23 4 of of IN cord-002728-6oyw5sqv 23 5 the the DT cord-002728-6oyw5sqv 23 6 human human JJ cord-002728-6oyw5sqv 23 7 gut gut NN cord-002728-6oyw5sqv 23 8 microbiota microbiota NN cord-002728-6oyw5sqv 23 9 plays play NNS cord-002728-6oyw5sqv 23 10 in in IN cord-002728-6oyw5sqv 23 11 health health NN cord-002728-6oyw5sqv 23 12 and and CC cord-002728-6oyw5sqv 23 13 disease disease NN cord-002728-6oyw5sqv 23 14 . . . cord-002728-6oyw5sqv 24 1 The the DT cord-002728-6oyw5sqv 24 2 following follow VBG cord-002728-6oyw5sqv 24 3 reviews review NNS cord-002728-6oyw5sqv 24 4 our -PRON- PRP$ cord-002728-6oyw5sqv 24 5 current current JJ cord-002728-6oyw5sqv 24 6 knowledge knowledge NN cord-002728-6oyw5sqv 24 7 on on IN cord-002728-6oyw5sqv 24 8 the the DT cord-002728-6oyw5sqv 24 9 human human JJ cord-002728-6oyw5sqv 24 10 intestinal intestinal JJ cord-002728-6oyw5sqv 24 11 virome virome NN cord-002728-6oyw5sqv 24 12 . . . cord-002728-6oyw5sqv 25 1 A a DT cord-002728-6oyw5sqv 25 2 virome virome NN cord-002728-6oyw5sqv 25 3 comprises comprise VBZ cord-002728-6oyw5sqv 25 4 all all PDT cord-002728-6oyw5sqv 25 5 the the DT cord-002728-6oyw5sqv 25 6 nucleic nucleic JJ cord-002728-6oyw5sqv 25 7 acids acid NNS cord-002728-6oyw5sqv 25 8 ( ( -LRB- cord-002728-6oyw5sqv 25 9 ssDNA ssdna RB cord-002728-6oyw5sqv 25 10 , , , cord-002728-6oyw5sqv 25 11 dsDNA dsdna RB cord-002728-6oyw5sqv 25 12 , , , cord-002728-6oyw5sqv 25 13 ssRNA ssrna NN cord-002728-6oyw5sqv 25 14 and and CC cord-002728-6oyw5sqv 25 15 dsRNA dsrna NN cord-002728-6oyw5sqv 25 16 ) ) -RRB- cord-002728-6oyw5sqv 25 17 belonging belong VBG cord-002728-6oyw5sqv 25 18 to to IN cord-002728-6oyw5sqv 25 19 the the DT cord-002728-6oyw5sqv 25 20 VLPs vlp NNS cord-002728-6oyw5sqv 25 21 associated associate VBN cord-002728-6oyw5sqv 25 22 with with IN cord-002728-6oyw5sqv 25 23 a a DT cord-002728-6oyw5sqv 25 24 particular particular JJ cord-002728-6oyw5sqv 25 25 ecosystem ecosystem NN cord-002728-6oyw5sqv 25 26 . . . cord-002728-6oyw5sqv 26 1 The the DT cord-002728-6oyw5sqv 26 2 human human JJ cord-002728-6oyw5sqv 26 3 virome virome NN cord-002728-6oyw5sqv 26 4 is be VBZ cord-002728-6oyw5sqv 26 5 a a DT cord-002728-6oyw5sqv 26 6 genetically genetically RB cord-002728-6oyw5sqv 26 7 complex complex JJ cord-002728-6oyw5sqv 26 8 component component NN cord-002728-6oyw5sqv 26 9 of of IN cord-002728-6oyw5sqv 26 10 the the DT cord-002728-6oyw5sqv 26 11 microbiome microbiome NN cord-002728-6oyw5sqv 26 12 , , , cord-002728-6oyw5sqv 26 13 with with IN cord-002728-6oyw5sqv 26 14 the the DT cord-002728-6oyw5sqv 26 15 blood blood NN cord-002728-6oyw5sqv 26 16 , , , cord-002728-6oyw5sqv 26 17 nose nose NN cord-002728-6oyw5sqv 26 18 , , , cord-002728-6oyw5sqv 26 19 skin skin NN cord-002728-6oyw5sqv 26 20 , , , cord-002728-6oyw5sqv 26 21 conjunctiva conjunctiva NN cord-002728-6oyw5sqv 26 22 , , , cord-002728-6oyw5sqv 26 23 mouth mouth NN cord-002728-6oyw5sqv 26 24 , , , cord-002728-6oyw5sqv 26 25 vagina vagina NN cord-002728-6oyw5sqv 26 26 , , , cord-002728-6oyw5sqv 26 27 lungs lung NNS cord-002728-6oyw5sqv 26 28 and and CC cord-002728-6oyw5sqv 26 29 gastrointestinal gastrointestinal JJ cord-002728-6oyw5sqv 26 30 ( ( -LRB- cord-002728-6oyw5sqv 26 31 GI GI NNP cord-002728-6oyw5sqv 26 32 ) ) -RRB- cord-002728-6oyw5sqv 26 33 tract tract NN cord-002728-6oyw5sqv 26 34 harbouring harbour VBG cord-002728-6oyw5sqv 26 35 their -PRON- PRP$ cord-002728-6oyw5sqv 26 36 own own JJ cord-002728-6oyw5sqv 26 37 distinct distinct JJ cord-002728-6oyw5sqv 26 38 virus virus NN cord-002728-6oyw5sqv 26 39 assemblages assemblage NNS cord-002728-6oyw5sqv 26 40 ( ( -LRB- cord-002728-6oyw5sqv 26 41 Table Table NNP cord-002728-6oyw5sqv 26 42 S1 S1 NNP cord-002728-6oyw5sqv 26 43 ) ) -RRB- cord-002728-6oyw5sqv 26 44 . . . cord-002728-6oyw5sqv 27 1 The the DT cord-002728-6oyw5sqv 27 2 genetic genetic JJ cord-002728-6oyw5sqv 27 3 content content NN cord-002728-6oyw5sqv 27 4 of of IN cord-002728-6oyw5sqv 27 5 VLPs vlp NNS cord-002728-6oyw5sqv 27 6 comprising comprise VBG cord-002728-6oyw5sqv 27 7 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 27 8 ( ( -LRB- cord-002728-6oyw5sqv 27 9 phages phage NNS cord-002728-6oyw5sqv 27 10 ) ) -RRB- cord-002728-6oyw5sqv 27 11 that that WDT cord-002728-6oyw5sqv 27 12 infect infect VBP cord-002728-6oyw5sqv 27 13 bacteria bacteria NNS cord-002728-6oyw5sqv 27 14 and and CC cord-002728-6oyw5sqv 27 15 archaea archaea NNS cord-002728-6oyw5sqv 27 16 and and CC cord-002728-6oyw5sqv 27 17 , , , cord-002728-6oyw5sqv 27 18 to to IN cord-002728-6oyw5sqv 27 19 a a DT cord-002728-6oyw5sqv 27 20 much much RB cord-002728-6oyw5sqv 27 21 lesser less JJR cord-002728-6oyw5sqv 27 22 extent extent NN cord-002728-6oyw5sqv 27 23 , , , cord-002728-6oyw5sqv 27 24 human- human- NN cord-002728-6oyw5sqv 27 25 , , , cord-002728-6oyw5sqv 27 26 plant- plant- JJ cord-002728-6oyw5sqv 27 27 , , , cord-002728-6oyw5sqv 27 28 amoebae amoebae NN cord-002728-6oyw5sqv 27 29 - - HYPH cord-002728-6oyw5sqv 27 30 and and CC cord-002728-6oyw5sqv 27 31 animal animal NN cord-002728-6oyw5sqv 27 32 - - HYPH cord-002728-6oyw5sqv 27 33 infecting infect VBG cord-002728-6oyw5sqv 27 34 viruses virus NNS cord-002728-6oyw5sqv 27 35 found find VBN cord-002728-6oyw5sqv 27 36 along along IN cord-002728-6oyw5sqv 27 37 the the DT cord-002728-6oyw5sqv 27 38 GI GI NNP cord-002728-6oyw5sqv 27 39 tract tract NN cord-002728-6oyw5sqv 27 40 constitute constitute VBP cord-002728-6oyw5sqv 27 41 the the DT cord-002728-6oyw5sqv 27 42 human human JJ cord-002728-6oyw5sqv 27 43 intestinal intestinal JJ cord-002728-6oyw5sqv 27 44 virome virome NN cord-002728-6oyw5sqv 27 45 ( ( -LRB- cord-002728-6oyw5sqv 27 46 Figure figure NN cord-002728-6oyw5sqv 27 47 1 1 CD cord-002728-6oyw5sqv 27 48 ) ) -RRB- cord-002728-6oyw5sqv 27 49 . . . cord-002728-6oyw5sqv 28 1 Phages phage NNS cord-002728-6oyw5sqv 28 2 can can MD cord-002728-6oyw5sqv 28 3 be be VB cord-002728-6oyw5sqv 28 4 lytic lytic JJ cord-002728-6oyw5sqv 28 5 or or CC cord-002728-6oyw5sqv 28 6 lysogenic lysogenic JJ cord-002728-6oyw5sqv 28 7 . . . cord-002728-6oyw5sqv 29 1 Lytic lytic JJ cord-002728-6oyw5sqv 29 2 ( ( -LRB- cord-002728-6oyw5sqv 29 3 virulent virulent JJ cord-002728-6oyw5sqv 29 4 ) ) -RRB- cord-002728-6oyw5sqv 29 5 phages phage NNS cord-002728-6oyw5sqv 29 6 bind bind VBP cord-002728-6oyw5sqv 29 7 to to IN cord-002728-6oyw5sqv 29 8 specific specific JJ cord-002728-6oyw5sqv 29 9 host host NN cord-002728-6oyw5sqv 29 10 - - HYPH cord-002728-6oyw5sqv 29 11 cell cell NN cord-002728-6oyw5sqv 29 12 receptors receptor NNS cord-002728-6oyw5sqv 29 13 , , , cord-002728-6oyw5sqv 29 14 then then RB cord-002728-6oyw5sqv 29 15 penetrate penetrate VB cord-002728-6oyw5sqv 29 16 and and CC cord-002728-6oyw5sqv 29 17 infect infect VB cord-002728-6oyw5sqv 29 18 their -PRON- PRP$ cord-002728-6oyw5sqv 29 19 host host NN cord-002728-6oyw5sqv 29 20 cell cell NN cord-002728-6oyw5sqv 29 21 to to TO cord-002728-6oyw5sqv 29 22 hijack hijack VB cord-002728-6oyw5sqv 29 23 its -PRON- PRP$ cord-002728-6oyw5sqv 29 24 replication replication NN cord-002728-6oyw5sqv 29 25 and and CC cord-002728-6oyw5sqv 29 26 translation translation NN cord-002728-6oyw5sqv 29 27 machinery machinery NN cord-002728-6oyw5sqv 29 28 to to TO cord-002728-6oyw5sqv 29 29 produce produce VB cord-002728-6oyw5sqv 29 30 virions virion NNS cord-002728-6oyw5sqv 29 31 ; ; : cord-002728-6oyw5sqv 29 32 once once IN cord-002728-6oyw5sqv 29 33 sufficient sufficient JJ cord-002728-6oyw5sqv 29 34 virions virion NNS cord-002728-6oyw5sqv 29 35 have have VBP cord-002728-6oyw5sqv 29 36 accumulated accumulate VBN cord-002728-6oyw5sqv 29 37 ( ( -LRB- cord-002728-6oyw5sqv 29 38 tens ten NNS cord-002728-6oyw5sqv 29 39 to to IN cord-002728-6oyw5sqv 29 40 thousands thousand NNS cord-002728-6oyw5sqv 29 41 , , , cord-002728-6oyw5sqv 29 42 depending depend VBG cord-002728-6oyw5sqv 29 43 on on IN cord-002728-6oyw5sqv 29 44 the the DT cord-002728-6oyw5sqv 29 45 phage phage NN cord-002728-6oyw5sqv 29 46 ) ) -RRB- cord-002728-6oyw5sqv 30 1 , , , cord-002728-6oyw5sqv 30 2 the the DT cord-002728-6oyw5sqv 30 3 lytic lytic JJ cord-002728-6oyw5sqv 30 4 enzymes enzyme NNS cord-002728-6oyw5sqv 30 5 they -PRON- PRP cord-002728-6oyw5sqv 30 6 produce produce VBP cord-002728-6oyw5sqv 30 7 cause cause VB cord-002728-6oyw5sqv 30 8 the the DT cord-002728-6oyw5sqv 30 9 host host NN cord-002728-6oyw5sqv 30 10 cell cell NN cord-002728-6oyw5sqv 30 11 to to TO cord-002728-6oyw5sqv 30 12 lyse lyse VB cord-002728-6oyw5sqv 30 13 , , , cord-002728-6oyw5sqv 30 14 releasing release VBG cord-002728-6oyw5sqv 30 15 the the DT cord-002728-6oyw5sqv 30 16 virions virion NNS cord-002728-6oyw5sqv 30 17 into into IN cord-002728-6oyw5sqv 30 18 the the DT cord-002728-6oyw5sqv 30 19 surrounding surround VBG cord-002728-6oyw5sqv 30 20 environment environment NN cord-002728-6oyw5sqv 30 21 where where WRB cord-002728-6oyw5sqv 30 22 they -PRON- PRP cord-002728-6oyw5sqv 30 23 can can MD cord-002728-6oyw5sqv 30 24 infect infect VB cord-002728-6oyw5sqv 30 25 new new JJ cord-002728-6oyw5sqv 30 26 host host NN cord-002728-6oyw5sqv 30 27 cells cell NNS cord-002728-6oyw5sqv 30 28 . . . cord-002728-6oyw5sqv 31 1 Lytic lytic JJ cord-002728-6oyw5sqv 31 2 phages phage NNS cord-002728-6oyw5sqv 31 3 can can MD cord-002728-6oyw5sqv 31 4 have have VB cord-002728-6oyw5sqv 31 5 narrow narrow JJ cord-002728-6oyw5sqv 31 6 or or CC cord-002728-6oyw5sqv 31 7 broad broad JJ cord-002728-6oyw5sqv 31 8 host host NN cord-002728-6oyw5sqv 31 9 ranges range NNS cord-002728-6oyw5sqv 31 10 , , , cord-002728-6oyw5sqv 31 11 infecting infect VBG cord-002728-6oyw5sqv 31 12 only only RB cord-002728-6oyw5sqv 31 13 one one CD cord-002728-6oyw5sqv 31 14 strain strain NN cord-002728-6oyw5sqv 31 15 of of IN cord-002728-6oyw5sqv 31 16 a a DT cord-002728-6oyw5sqv 31 17 prokaryote prokaryote NN cord-002728-6oyw5sqv 31 18 or or CC cord-002728-6oyw5sqv 31 19 multiple multiple JJ cord-002728-6oyw5sqv 31 20 species specie NNS cord-002728-6oyw5sqv 31 21 of of IN cord-002728-6oyw5sqv 31 22 closely closely RB cord-002728-6oyw5sqv 31 23 related related JJ cord-002728-6oyw5sqv 31 24 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 31 25 . . . cord-002728-6oyw5sqv 32 1 These these DT cord-002728-6oyw5sqv 32 2 entities entity NNS cord-002728-6oyw5sqv 32 3 have have VBP cord-002728-6oyw5sqv 32 4 been be VBN cord-002728-6oyw5sqv 32 5 used use VBN cord-002728-6oyw5sqv 32 6 in in IN cord-002728-6oyw5sqv 32 7 the the DT cord-002728-6oyw5sqv 32 8 past past NN cord-002728-6oyw5sqv 32 9 to to TO cord-002728-6oyw5sqv 32 10 treat treat VB cord-002728-6oyw5sqv 32 11 infections infection NNS cord-002728-6oyw5sqv 32 12 , , , cord-002728-6oyw5sqv 32 13 and and CC cord-002728-6oyw5sqv 32 14 have have VBP cord-002728-6oyw5sqv 32 15 recently recently RB cord-002728-6oyw5sqv 32 16 been be VBN cord-002728-6oyw5sqv 32 17 revisited revisit VBN cord-002728-6oyw5sqv 32 18 as as IN cord-002728-6oyw5sqv 32 19 alternatives alternative NNS cord-002728-6oyw5sqv 32 20 to to IN cord-002728-6oyw5sqv 32 21 antibiotic antibiotic JJ cord-002728-6oyw5sqv 32 22 therapies therapy NNS cord-002728-6oyw5sqv 32 23 for for IN cord-002728-6oyw5sqv 32 24 a a DT cord-002728-6oyw5sqv 32 25 range range NN cord-002728-6oyw5sqv 32 26 of of IN cord-002728-6oyw5sqv 32 27 infections infection NNS cord-002728-6oyw5sqv 32 28 and and CC cord-002728-6oyw5sqv 32 29 as as IN cord-002728-6oyw5sqv 32 30 means mean NNS cord-002728-6oyw5sqv 32 31 of of IN cord-002728-6oyw5sqv 32 32 controlling control VBG cord-002728-6oyw5sqv 32 33 food food NN cord-002728-6oyw5sqv 32 34 - - HYPH cord-002728-6oyw5sqv 32 35 contaminating contaminate VBG cord-002728-6oyw5sqv 32 36 bacteria bacteria NNS cord-002728-6oyw5sqv 32 37 such such JJ cord-002728-6oyw5sqv 32 38 as as IN cord-002728-6oyw5sqv 32 39 Listeria Listeria NNP cord-002728-6oyw5sqv 32 40 spp spp NNP cord-002728-6oyw5sqv 32 41 . . . cord-002728-6oyw5sqv 33 1 3 3 LS cord-002728-6oyw5sqv 34 1 Their -PRON- PRP$ cord-002728-6oyw5sqv 34 2 gene gene NN cord-002728-6oyw5sqv 34 3 products product NNS cord-002728-6oyw5sqv 34 4 are be VBP cord-002728-6oyw5sqv 34 5 also also RB cord-002728-6oyw5sqv 34 6 of of IN cord-002728-6oyw5sqv 34 7 interest interest NN cord-002728-6oyw5sqv 34 8 in in IN cord-002728-6oyw5sqv 34 9 biotechnological biotechnological JJ cord-002728-6oyw5sqv 34 10 and and CC cord-002728-6oyw5sqv 34 11 medical medical JJ cord-002728-6oyw5sqv 34 12 applications application NNS cord-002728-6oyw5sqv 34 13 . . . cord-002728-6oyw5sqv 35 1 4 4 LS cord-002728-6oyw5sqv 36 1 The the DT cord-002728-6oyw5sqv 36 2 mammalian mammalian JJ cord-002728-6oyw5sqv 36 3 intestinal intestinal JJ cord-002728-6oyw5sqv 36 4 virome virome NN cord-002728-6oyw5sqv 36 5 comprises comprise VBZ cord-002728-6oyw5sqv 36 6 viruses virus NNS cord-002728-6oyw5sqv 36 7 that that WDT cord-002728-6oyw5sqv 36 8 infect infect VBP cord-002728-6oyw5sqv 36 9 eukaryotic eukaryotic JJ cord-002728-6oyw5sqv 36 10 and and CC cord-002728-6oyw5sqv 36 11 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 36 12 cells cell NNS cord-002728-6oyw5sqv 36 13 . . . cord-002728-6oyw5sqv 37 1 It -PRON- PRP cord-002728-6oyw5sqv 37 2 is be VBZ cord-002728-6oyw5sqv 37 3 established establish VBN cord-002728-6oyw5sqv 37 4 soon soon RB cord-002728-6oyw5sqv 37 5 after after IN cord-002728-6oyw5sqv 37 6 birth birth NN cord-002728-6oyw5sqv 37 7 and and CC cord-002728-6oyw5sqv 37 8 is be VBZ cord-002728-6oyw5sqv 37 9 dominated dominate VBN cord-002728-6oyw5sqv 37 10 by by IN cord-002728-6oyw5sqv 37 11 viruses virus NNS cord-002728-6oyw5sqv 37 12 that that WDT cord-002728-6oyw5sqv 37 13 infect infect VBP cord-002728-6oyw5sqv 37 14 bacteria bacteria NNS cord-002728-6oyw5sqv 37 15 ( ( -LRB- cord-002728-6oyw5sqv 37 16 ie ie NNS cord-002728-6oyw5sqv 37 17 , , , cord-002728-6oyw5sqv 37 18 phages phage NNS cord-002728-6oyw5sqv 37 19 ) ) -RRB- cord-002728-6oyw5sqv 37 20 . . . cord-002728-6oyw5sqv 38 1 The the DT cord-002728-6oyw5sqv 38 2 virome virome NN cord-002728-6oyw5sqv 38 3 establishes establish VBZ cord-002728-6oyw5sqv 38 4 a a DT cord-002728-6oyw5sqv 38 5 mutualistic mutualistic JJ cord-002728-6oyw5sqv 38 6 relationship relationship NN cord-002728-6oyw5sqv 38 7 with with IN cord-002728-6oyw5sqv 38 8 eukaryotes eukaryote NNS cord-002728-6oyw5sqv 38 9 / / SYM cord-002728-6oyw5sqv 38 10 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 38 11 , , , cord-002728-6oyw5sqv 38 12 contributing contribute VBG cord-002728-6oyw5sqv 38 13 to to IN cord-002728-6oyw5sqv 38 14 intestinal intestinal JJ cord-002728-6oyw5sqv 38 15 homeostasis homeostasis NN cord-002728-6oyw5sqv 38 16 by by IN cord-002728-6oyw5sqv 38 17 influencing influence VBG cord-002728-6oyw5sqv 38 18 microbial microbial JJ cord-002728-6oyw5sqv 38 19 ecology ecology NN cord-002728-6oyw5sqv 38 20 and and CC cord-002728-6oyw5sqv 38 21 host host NN cord-002728-6oyw5sqv 38 22 immunity immunity NN cord-002728-6oyw5sqv 38 23 . . . cord-002728-6oyw5sqv 39 1 Composition composition NN cord-002728-6oyw5sqv 39 2 of of IN cord-002728-6oyw5sqv 39 3 the the DT cord-002728-6oyw5sqv 39 4 virome virome NN cord-002728-6oyw5sqv 39 5 is be VBZ cord-002728-6oyw5sqv 39 6 influenced influence VBN cord-002728-6oyw5sqv 39 7 by by IN cord-002728-6oyw5sqv 39 8 numerous numerous JJ cord-002728-6oyw5sqv 39 9 factors factor NNS cord-002728-6oyw5sqv 39 10 that that WDT cord-002728-6oyw5sqv 39 11 affect affect VBP cord-002728-6oyw5sqv 39 12 viruses virus NNS cord-002728-6oyw5sqv 39 13 directly directly RB cord-002728-6oyw5sqv 39 14 ( ( -LRB- cord-002728-6oyw5sqv 39 15 infection infection NN cord-002728-6oyw5sqv 39 16 ) ) -RRB- cord-002728-6oyw5sqv 39 17 or or CC cord-002728-6oyw5sqv 39 18 change change VB cord-002728-6oyw5sqv 39 19 host host NN cord-002728-6oyw5sqv 39 20 - - HYPH cord-002728-6oyw5sqv 39 21 cell cell NN cord-002728-6oyw5sqv 39 22 populations population NNS cord-002728-6oyw5sqv 39 23 ( ( -LRB- cord-002728-6oyw5sqv 39 24 eg eg RB cord-002728-6oyw5sqv 39 25 , , , cord-002728-6oyw5sqv 39 26 antibiotics antibiotic NNS cord-002728-6oyw5sqv 39 27 , , , cord-002728-6oyw5sqv 39 28 diet diet NN cord-002728-6oyw5sqv 39 29 ) ) -RRB- cord-002728-6oyw5sqv 39 30 . . . cord-002728-6oyw5sqv 40 1 Members member NNS cord-002728-6oyw5sqv 40 2 of of IN cord-002728-6oyw5sqv 40 3 the the DT cord-002728-6oyw5sqv 40 4 virome virome NN cord-002728-6oyw5sqv 40 5 may may MD cord-002728-6oyw5sqv 40 6 contribute contribute VB cord-002728-6oyw5sqv 40 7 to to IN cord-002728-6oyw5sqv 40 8 the the DT cord-002728-6oyw5sqv 40 9 pathogenesis pathogenesis NN cord-002728-6oyw5sqv 40 10 of of IN cord-002728-6oyw5sqv 40 11 certain certain JJ cord-002728-6oyw5sqv 40 12 diseases disease NNS cord-002728-6oyw5sqv 40 13 via via IN cord-002728-6oyw5sqv 40 14 microbial microbial JJ cord-002728-6oyw5sqv 40 15 host host NN cord-002728-6oyw5sqv 40 16 lysis lysis NN cord-002728-6oyw5sqv 40 17 leading lead VBG cord-002728-6oyw5sqv 40 18 to to IN cord-002728-6oyw5sqv 40 19 dysbiosis dysbiosis NN cord-002728-6oyw5sqv 40 20 , , , cord-002728-6oyw5sqv 40 21 infection infection NN cord-002728-6oyw5sqv 40 22 of of IN cord-002728-6oyw5sqv 40 23 epithelial epithelial JJ cord-002728-6oyw5sqv 40 24 cells cell NNS cord-002728-6oyw5sqv 40 25 , , , cord-002728-6oyw5sqv 40 26 and/or and/or CC cord-002728-6oyw5sqv 40 27 translocation translocation NN cord-002728-6oyw5sqv 40 28 of of IN cord-002728-6oyw5sqv 40 29 the the DT cord-002728-6oyw5sqv 40 30 compromised compromised JJ cord-002728-6oyw5sqv 40 31 or or CC cord-002728-6oyw5sqv 40 32 damaged damage VBN cord-002728-6oyw5sqv 40 33 mucosal mucosal JJ cord-002728-6oyw5sqv 40 34 barrier barrier NN cord-002728-6oyw5sqv 40 35 to to TO cord-002728-6oyw5sqv 40 36 gain gain VB cord-002728-6oyw5sqv 40 37 access access NN cord-002728-6oyw5sqv 40 38 to to IN cord-002728-6oyw5sqv 40 39 underlying underlie VBG cord-002728-6oyw5sqv 40 40 tissues tissue NNS cord-002728-6oyw5sqv 40 41 and and CC cord-002728-6oyw5sqv 40 42 immune immune JJ cord-002728-6oyw5sqv 40 43 cells cell NNS cord-002728-6oyw5sqv 40 44 , , , cord-002728-6oyw5sqv 40 45 leading lead VBG cord-002728-6oyw5sqv 40 46 to to IN cord-002728-6oyw5sqv 40 47 immune immune JJ cord-002728-6oyw5sqv 40 48 activation activation NN cord-002728-6oyw5sqv 40 49 . . . cord-002728-6oyw5sqv 41 1 Dysbiosis Dysbiosis NNP cord-002728-6oyw5sqv 41 2 can can MD cord-002728-6oyw5sqv 41 3 be be VB cord-002728-6oyw5sqv 41 4 defined define VBN cord-002728-6oyw5sqv 41 5 as as IN cord-002728-6oyw5sqv 41 6 a a DT cord-002728-6oyw5sqv 41 7 microbial microbial JJ cord-002728-6oyw5sqv 41 8 imbalance imbalance NN cord-002728-6oyw5sqv 41 9 or or CC cord-002728-6oyw5sqv 41 10 any any DT cord-002728-6oyw5sqv 41 11 changes change NNS cord-002728-6oyw5sqv 41 12 to to IN cord-002728-6oyw5sqv 41 13 the the DT cord-002728-6oyw5sqv 41 14 composition composition NN cord-002728-6oyw5sqv 41 15 of of IN cord-002728-6oyw5sqv 41 16 resident resident JJ cord-002728-6oyw5sqv 41 17 microbial microbial JJ cord-002728-6oyw5sqv 41 18 communities community NNS cord-002728-6oyw5sqv 41 19 relative relative JJ cord-002728-6oyw5sqv 41 20 to to IN cord-002728-6oyw5sqv 41 21 the the DT cord-002728-6oyw5sqv 41 22 community community NN cord-002728-6oyw5sqv 41 23 found find VBN cord-002728-6oyw5sqv 41 24 in in IN cord-002728-6oyw5sqv 41 25 healthy healthy JJ cord-002728-6oyw5sqv 41 26 individuals individual NNS cord-002728-6oyw5sqv 41 27 . . . cord-002728-6oyw5sqv 42 1 [ [ -LRB- cord-002728-6oyw5sqv 42 2 101 101 CD cord-002728-6oyw5sqv 42 3 ] ] -RRB- cord-002728-6oyw5sqv 42 4 [ [ -LRB- cord-002728-6oyw5sqv 42 5 102 102 CD cord-002728-6oyw5sqv 42 6 ] ] -RRB- cord-002728-6oyw5sqv 42 7 [ [ -LRB- cord-002728-6oyw5sqv 42 8 103 103 CD cord-002728-6oyw5sqv 42 9 ] ] -RRB- cord-002728-6oyw5sqv 43 1 Virome Virome NNP cord-002728-6oyw5sqv 43 2 association association NN cord-002728-6oyw5sqv 43 3 with with IN cord-002728-6oyw5sqv 43 4 certain certain JJ cord-002728-6oyw5sqv 43 5 disease disease NN cord-002728-6oyw5sqv 43 6 states state NNS cord-002728-6oyw5sqv 43 7 is be VBZ cord-002728-6oyw5sqv 43 8 characterised characterise VBN cord-002728-6oyw5sqv 43 9 by by IN cord-002728-6oyw5sqv 43 10 changes change NNS cord-002728-6oyw5sqv 43 11 in in IN cord-002728-6oyw5sqv 43 12 diversity diversity NN cord-002728-6oyw5sqv 43 13 , , , cord-002728-6oyw5sqv 43 14 and and CC cord-002728-6oyw5sqv 43 15 predominance predominance NN cord-002728-6oyw5sqv 43 16 of of IN cord-002728-6oyw5sqv 43 17 specific specific JJ cord-002728-6oyw5sqv 43 18 virotypes virotype NNS cord-002728-6oyw5sqv 43 19 ( ( -LRB- cord-002728-6oyw5sqv 43 20 eg eg UH cord-002728-6oyw5sqv 43 21 , , , cord-002728-6oyw5sqv 43 22 members member NNS cord-002728-6oyw5sqv 43 23 of of IN cord-002728-6oyw5sqv 43 24 the the DT cord-002728-6oyw5sqv 43 25 order order NN cord-002728-6oyw5sqv 43 26 Caudovirales Caudovirales NNP cord-002728-6oyw5sqv 43 27 in in IN cord-002728-6oyw5sqv 43 28 IBD IBD NNP cord-002728-6oyw5sqv 43 29 ) ) -RRB- cord-002728-6oyw5sqv 43 30 ( ( -LRB- cord-002728-6oyw5sqv 43 31 temperate temperate JJ cord-002728-6oyw5sqv 43 32 ) ) -RRB- cord-002728-6oyw5sqv 43 33 phages phage NNS cord-002728-6oyw5sqv 43 34 do do VBP cord-002728-6oyw5sqv 43 35 not not RB cord-002728-6oyw5sqv 43 36 kill kill VB cord-002728-6oyw5sqv 43 37 their -PRON- PRP$ cord-002728-6oyw5sqv 43 38 host host NN cord-002728-6oyw5sqv 43 39 but but CC cord-002728-6oyw5sqv 43 40 instead instead RB cord-002728-6oyw5sqv 43 41 integrate integrate VB cord-002728-6oyw5sqv 43 42 into into IN cord-002728-6oyw5sqv 43 43 their -PRON- PRP$ cord-002728-6oyw5sqv 43 44 host host NN cord-002728-6oyw5sqv 43 45 's 's POS cord-002728-6oyw5sqv 43 46 genome genome NN cord-002728-6oyw5sqv 43 47 without without IN cord-002728-6oyw5sqv 43 48 interfering interfere VBG cord-002728-6oyw5sqv 43 49 with with IN cord-002728-6oyw5sqv 43 50 its -PRON- PRP$ cord-002728-6oyw5sqv 43 51 replication replication NN cord-002728-6oyw5sqv 43 52 , , , cord-002728-6oyw5sqv 43 53 incorporating incorporate VBG cord-002728-6oyw5sqv 43 54 the the DT cord-002728-6oyw5sqv 43 55 phage phage NN cord-002728-6oyw5sqv 43 56 into into IN cord-002728-6oyw5sqv 43 57 its -PRON- PRP$ cord-002728-6oyw5sqv 43 58 genome genome NN cord-002728-6oyw5sqv 43 59 as as IN cord-002728-6oyw5sqv 43 60 a a DT cord-002728-6oyw5sqv 43 61 prophage prophage NN cord-002728-6oyw5sqv 43 62 that that WDT cord-002728-6oyw5sqv 43 63 is be VBZ cord-002728-6oyw5sqv 43 64 transmitted transmit VBN cord-002728-6oyw5sqv 43 65 to to IN cord-002728-6oyw5sqv 43 66 its -PRON- PRP$ cord-002728-6oyw5sqv 43 67 progeny progeny NN cord-002728-6oyw5sqv 43 68 at at IN cord-002728-6oyw5sqv 43 69 each each DT cord-002728-6oyw5sqv 43 70 cell cell NN cord-002728-6oyw5sqv 43 71 division division NN cord-002728-6oyw5sqv 43 72 . . . cord-002728-6oyw5sqv 44 1 Lysogenic Lysogenic NNP cord-002728-6oyw5sqv 44 2 phages phage NNS cord-002728-6oyw5sqv 44 3 can can MD cord-002728-6oyw5sqv 44 4 be be VB cord-002728-6oyw5sqv 44 5 converted convert VBN cord-002728-6oyw5sqv 44 6 to to IN cord-002728-6oyw5sqv 44 7 a a DT cord-002728-6oyw5sqv 44 8 lytic lytic JJ cord-002728-6oyw5sqv 44 9 cycle cycle NN cord-002728-6oyw5sqv 44 10 in in IN cord-002728-6oyw5sqv 44 11 response response NN cord-002728-6oyw5sqv 44 12 to to IN cord-002728-6oyw5sqv 44 13 environmental environmental JJ cord-002728-6oyw5sqv 44 14 stressors stressor NNS cord-002728-6oyw5sqv 44 15 ( ( -LRB- cord-002728-6oyw5sqv 44 16 eg eg RB cord-002728-6oyw5sqv 44 17 , , , cord-002728-6oyw5sqv 44 18 antibiotics antibiotic NNS cord-002728-6oyw5sqv 44 19 ) ) -RRB- cord-002728-6oyw5sqv 44 20 . . . cord-002728-6oyw5sqv 45 1 Phage phage NN cord-002728-6oyw5sqv 45 2 - - HYPH cord-002728-6oyw5sqv 45 3 host host NN cord-002728-6oyw5sqv 45 4 interactions interaction NNS cord-002728-6oyw5sqv 45 5 influence influence VBP cord-002728-6oyw5sqv 45 6 host host NN cord-002728-6oyw5sqv 45 7 and and CC cord-002728-6oyw5sqv 45 8 viral viral JJ cord-002728-6oyw5sqv 45 9 evolution evolution NN cord-002728-6oyw5sqv 45 10 . . . cord-002728-6oyw5sqv 46 1 The the DT cord-002728-6oyw5sqv 46 2 ability ability NN cord-002728-6oyw5sqv 46 3 of of IN cord-002728-6oyw5sqv 46 4 phages phage NNS cord-002728-6oyw5sqv 46 5 to to TO cord-002728-6oyw5sqv 46 6 transfer transfer VB cord-002728-6oyw5sqv 46 7 genes gene NNS cord-002728-6oyw5sqv 46 8 from from IN cord-002728-6oyw5sqv 46 9 one one CD cord-002728-6oyw5sqv 46 10 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 46 11 host host NN cord-002728-6oyw5sqv 46 12 to to IN cord-002728-6oyw5sqv 46 13 another another DT cord-002728-6oyw5sqv 46 14 can can MD cord-002728-6oyw5sqv 46 15 lead lead VB cord-002728-6oyw5sqv 46 16 to to IN cord-002728-6oyw5sqv 46 17 increased increase VBN cord-002728-6oyw5sqv 46 18 diversification diversification NN cord-002728-6oyw5sqv 46 19 of of IN cord-002728-6oyw5sqv 46 20 viral viral JJ cord-002728-6oyw5sqv 46 21 species specie NNS cord-002728-6oyw5sqv 46 22 , , , cord-002728-6oyw5sqv 46 23 and and CC cord-002728-6oyw5sqv 46 24 increased increase VBN cord-002728-6oyw5sqv 46 25 antibiotic antibiotic JJ cord-002728-6oyw5sqv 46 26 resistance resistance NN cord-002728-6oyw5sqv 46 27 and/or and/or CC cord-002728-6oyw5sqv 46 28 induction induction NN cord-002728-6oyw5sqv 46 29 of of IN cord-002728-6oyw5sqv 46 30 toxins toxin NNS cord-002728-6oyw5sqv 46 31 or or CC cord-002728-6oyw5sqv 46 32 virulence virulence NN cord-002728-6oyw5sqv 46 33 factors factor NNS cord-002728-6oyw5sqv 46 34 in in IN cord-002728-6oyw5sqv 46 35 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 46 36 . . . cord-002728-6oyw5sqv 47 1 5 5 LS cord-002728-6oyw5sqv 48 1 Some some DT cord-002728-6oyw5sqv 48 2 phages phage NNS cord-002728-6oyw5sqv 48 3 alter alter VBP cord-002728-6oyw5sqv 48 4 the the DT cord-002728-6oyw5sqv 48 5 antigenicity antigenicity NN cord-002728-6oyw5sqv 48 6 of of IN cord-002728-6oyw5sqv 48 7 their -PRON- PRP$ cord-002728-6oyw5sqv 48 8 hosts host NNS cord-002728-6oyw5sqv 48 9 by by IN cord-002728-6oyw5sqv 48 10 producing produce VBG cord-002728-6oyw5sqv 48 11 enzymes enzyme NNS cord-002728-6oyw5sqv 48 12 that that WDT cord-002728-6oyw5sqv 48 13 modify modify VBP cord-002728-6oyw5sqv 48 14 the the DT cord-002728-6oyw5sqv 48 15 O o NN cord-002728-6oyw5sqv 48 16 - - HYPH cord-002728-6oyw5sqv 48 17 antigen antigen NN cord-002728-6oyw5sqv 48 18 component component NN cord-002728-6oyw5sqv 48 19 of of IN cord-002728-6oyw5sqv 48 20 lipopolysaccharides lipopolysaccharides NNP cord-002728-6oyw5sqv 48 21 . . . cord-002728-6oyw5sqv 49 1 6 6 CD cord-002728-6oyw5sqv 49 2 Modification modification NN cord-002728-6oyw5sqv 49 3 of of IN cord-002728-6oyw5sqv 49 4 surface surface NN cord-002728-6oyw5sqv 49 5 structures structure NNS cord-002728-6oyw5sqv 49 6 of of IN cord-002728-6oyw5sqv 49 7 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 49 8 has have VBZ cord-002728-6oyw5sqv 49 9 the the DT cord-002728-6oyw5sqv 49 10 potential potential NN cord-002728-6oyw5sqv 49 11 to to TO cord-002728-6oyw5sqv 49 12 affect affect VB cord-002728-6oyw5sqv 49 13 microbial microbial JJ cord-002728-6oyw5sqv 49 14 interactions interaction NNS cord-002728-6oyw5sqv 49 15 with with IN cord-002728-6oyw5sqv 49 16 the the DT cord-002728-6oyw5sqv 49 17 human human JJ cord-002728-6oyw5sqv 49 18 host host NN cord-002728-6oyw5sqv 49 19 , , , cord-002728-6oyw5sqv 49 20 and and CC cord-002728-6oyw5sqv 49 21 influence influence NN cord-002728-6oyw5sqv 49 22 niche niche NN cord-002728-6oyw5sqv 49 23 specialisation specialisation NN cord-002728-6oyw5sqv 49 24 within within IN cord-002728-6oyw5sqv 49 25 the the DT cord-002728-6oyw5sqv 49 26 GI GI NNP cord-002728-6oyw5sqv 49 27 tract tract NN cord-002728-6oyw5sqv 49 28 . . . cord-002728-6oyw5sqv 50 1 7 7 CD cord-002728-6oyw5sqv 50 2 Presence presence NN cord-002728-6oyw5sqv 50 3 of of IN cord-002728-6oyw5sqv 50 4 clustered cluster VBN cord-002728-6oyw5sqv 50 5 regularly regularly RB cord-002728-6oyw5sqv 50 6 interspaced interspace VBD cord-002728-6oyw5sqv 50 7 short short JJ cord-002728-6oyw5sqv 50 8 palindromic palindromic JJ cord-002728-6oyw5sqv 50 9 repeats repeat NNS cord-002728-6oyw5sqv 50 10 ( ( -LRB- cord-002728-6oyw5sqv 50 11 CRISPRs CRISPRs NNP cord-002728-6oyw5sqv 50 12 ) ) -RRB- cord-002728-6oyw5sqv 50 13 confers confer VBZ cord-002728-6oyw5sqv 50 14 upon upon IN cord-002728-6oyw5sqv 50 15 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 50 16 resistance resistance NN cord-002728-6oyw5sqv 50 17 to to IN cord-002728-6oyw5sqv 50 18 phage phage NN cord-002728-6oyw5sqv 50 19 infection infection NN cord-002728-6oyw5sqv 50 20 and and CC cord-002728-6oyw5sqv 50 21 contributes contribute VBZ cord-002728-6oyw5sqv 50 22 to to IN cord-002728-6oyw5sqv 50 23 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 50 24 adaptive adaptive JJ cord-002728-6oyw5sqv 50 25 immunity immunity NN cord-002728-6oyw5sqv 50 26 . . . cord-002728-6oyw5sqv 51 1 Analyses analysis NNS cord-002728-6oyw5sqv 51 2 of of IN cord-002728-6oyw5sqv 51 3 metagenomic metagenomic NNP cord-002728-6oyw5sqv 51 4 sequence sequence NN cord-002728-6oyw5sqv 51 5 data datum NNS cord-002728-6oyw5sqv 51 6 provide provide VBP cord-002728-6oyw5sqv 51 7 detailed detailed JJ cord-002728-6oyw5sqv 51 8 information information NN cord-002728-6oyw5sqv 51 9 on on IN cord-002728-6oyw5sqv 51 10 phage phage NN cord-002728-6oyw5sqv 51 11 - - HYPH cord-002728-6oyw5sqv 51 12 host host NN cord-002728-6oyw5sqv 51 13 and and CC cord-002728-6oyw5sqv 51 14 phage phage NN cord-002728-6oyw5sqv 51 15 - - HYPH cord-002728-6oyw5sqv 51 16 phage phage NN cord-002728-6oyw5sqv 51 17 competition competition NN cord-002728-6oyw5sqv 51 18 within within IN cord-002728-6oyw5sqv 51 19 the the DT cord-002728-6oyw5sqv 51 20 human human JJ cord-002728-6oyw5sqv 51 21 faecal faecal JJ cord-002728-6oyw5sqv 51 22 microbiome microbiome NN cord-002728-6oyw5sqv 51 23 , , , cord-002728-6oyw5sqv 51 24 implying imply VBG cord-002728-6oyw5sqv 51 25 CRISPR CRISPR NNP cord-002728-6oyw5sqv 51 26 spacers spacer NNS cord-002728-6oyw5sqv 51 27 are be VBP cord-002728-6oyw5sqv 51 28 actively actively RB cord-002728-6oyw5sqv 51 29 and and CC cord-002728-6oyw5sqv 51 30 continuously continuously RB cord-002728-6oyw5sqv 51 31 acquired acquire VBN cord-002728-6oyw5sqv 51 32 by by IN cord-002728-6oyw5sqv 51 33 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 51 34 in in IN cord-002728-6oyw5sqv 51 35 response response NN cord-002728-6oyw5sqv 51 36 to to IN cord-002728-6oyw5sqv 51 37 the the DT cord-002728-6oyw5sqv 51 38 presence presence NN cord-002728-6oyw5sqv 51 39 of of IN cord-002728-6oyw5sqv 51 40 phages phage NNS cord-002728-6oyw5sqv 51 41 in in IN cord-002728-6oyw5sqv 51 42 the the DT cord-002728-6oyw5sqv 51 43 GI GI NNP cord-002728-6oyw5sqv 51 44 tract tract NN cord-002728-6oyw5sqv 51 45 . . . cord-002728-6oyw5sqv 52 1 8 8 CD cord-002728-6oyw5sqv 53 1 The the DT cord-002728-6oyw5sqv 53 2 potential potential JJ cord-002728-6oyw5sqv 53 3 effects effect NNS cord-002728-6oyw5sqv 53 4 of of IN cord-002728-6oyw5sqv 53 5 such such JJ cord-002728-6oyw5sqv 53 6 phage phage NN cord-002728-6oyw5sqv 53 7 - - HYPH cord-002728-6oyw5sqv 53 8 host host NN cord-002728-6oyw5sqv 53 9 interactions interaction NNS cord-002728-6oyw5sqv 53 10 on on IN cord-002728-6oyw5sqv 53 11 microbiota microbiota NN cord-002728-6oyw5sqv 53 12 composition composition NN cord-002728-6oyw5sqv 53 13 / / SYM cord-002728-6oyw5sqv 53 14 function function NN cord-002728-6oyw5sqv 53 15 or or CC cord-002728-6oyw5sqv 53 16 host host NN cord-002728-6oyw5sqv 53 17 health health NN cord-002728-6oyw5sqv 53 18 are be VBP cord-002728-6oyw5sqv 53 19 unknown unknown JJ cord-002728-6oyw5sqv 53 20 . . . cord-002728-6oyw5sqv 54 1 Viruses virus NNS cord-002728-6oyw5sqv 54 2 do do VBP cord-002728-6oyw5sqv 54 3 not not RB cord-002728-6oyw5sqv 54 4 encode encode VB cord-002728-6oyw5sqv 54 5 universally universally RB cord-002728-6oyw5sqv 54 6 conserved conserve VBN cord-002728-6oyw5sqv 54 7 genes gene NNS cord-002728-6oyw5sqv 54 8 such such JJ cord-002728-6oyw5sqv 54 9 as as IN cord-002728-6oyw5sqv 54 10 the the DT cord-002728-6oyw5sqv 54 11 16S 16S NNPS cord-002728-6oyw5sqv 54 12 or or CC cord-002728-6oyw5sqv 54 13 18S 18S NNPS cord-002728-6oyw5sqv 55 1 rRNA rrna JJ cord-002728-6oyw5sqv 55 2 genes gene NNS cord-002728-6oyw5sqv 55 3 of of IN cord-002728-6oyw5sqv 55 4 prokaryotes prokaryote NNS cord-002728-6oyw5sqv 55 5 and and CC cord-002728-6oyw5sqv 55 6 eukaryotes eukaryote NNS cord-002728-6oyw5sqv 55 7 , , , cord-002728-6oyw5sqv 55 8 respectively respectively RB cord-002728-6oyw5sqv 55 9 , , , cord-002728-6oyw5sqv 55 10 and and CC cord-002728-6oyw5sqv 55 11 are be VBP cord-002728-6oyw5sqv 55 12 genetically genetically RB cord-002728-6oyw5sqv 55 13 highly highly RB cord-002728-6oyw5sqv 55 14 diverse diverse JJ cord-002728-6oyw5sqv 55 15 . . . cord-002728-6oyw5sqv 56 1 Consequently consequently RB cord-002728-6oyw5sqv 56 2 , , , cord-002728-6oyw5sqv 56 3 it -PRON- PRP cord-002728-6oyw5sqv 56 4 is be VBZ cord-002728-6oyw5sqv 56 5 not not RB cord-002728-6oyw5sqv 56 6 possible possible JJ cord-002728-6oyw5sqv 56 7 to to TO cord-002728-6oyw5sqv 56 8 use use VB cord-002728-6oyw5sqv 56 9 metataxonomic metataxonomic JJ cord-002728-6oyw5sqv 56 10 approaches approach NNS cord-002728-6oyw5sqv 56 11 such such JJ cord-002728-6oyw5sqv 56 12 as as IN cord-002728-6oyw5sqv 56 13 16S 16S NNP cord-002728-6oyw5sqv 56 14 rRNA rrna NN cord-002728-6oyw5sqv 56 15 gene gene NN cord-002728-6oyw5sqv 56 16 sequencing sequencing NN cord-002728-6oyw5sqv 56 17 to to TO cord-002728-6oyw5sqv 56 18 characterise characterise VB cord-002728-6oyw5sqv 56 19 VLPs vlp NNS cord-002728-6oyw5sqv 56 20 within within IN cord-002728-6oyw5sqv 56 21 ecosystems ecosystem NNS cord-002728-6oyw5sqv 56 22 . . . cord-002728-6oyw5sqv 57 1 Traditionally traditionally RB cord-002728-6oyw5sqv 57 2 , , , cord-002728-6oyw5sqv 57 3 classical classical JJ cord-002728-6oyw5sqv 57 4 approaches approach NNS cord-002728-6oyw5sqv 57 5 - - : cord-002728-6oyw5sqv 57 6 mainly mainly RB cord-002728-6oyw5sqv 57 7 microscopy microscopy NN cord-002728-6oyw5sqv 57 8 and and CC cord-002728-6oyw5sqv 57 9 cultivation cultivation NN cord-002728-6oyw5sqv 57 10 - - , cord-002728-6oyw5sqv 57 11 have have VBP cord-002728-6oyw5sqv 57 12 been be VBN cord-002728-6oyw5sqv 57 13 relied rely VBN cord-002728-6oyw5sqv 57 14 upon upon IN cord-002728-6oyw5sqv 57 15 to to TO cord-002728-6oyw5sqv 57 16 characterise characterise VB cord-002728-6oyw5sqv 57 17 VLPs vlp NNS cord-002728-6oyw5sqv 57 18 in in IN cord-002728-6oyw5sqv 57 19 the the DT cord-002728-6oyw5sqv 57 20 human human JJ cord-002728-6oyw5sqv 57 21 gut gut NN cord-002728-6oyw5sqv 57 22 . . . cord-002728-6oyw5sqv 58 1 Based base VBN cord-002728-6oyw5sqv 58 2 on on IN cord-002728-6oyw5sqv 58 3 transmission transmission NN cord-002728-6oyw5sqv 58 4 electron electron NN cord-002728-6oyw5sqv 58 5 microscopy microscopy NN cord-002728-6oyw5sqv 58 6 ( ( -LRB- cord-002728-6oyw5sqv 58 7 TEM TEM NNP cord-002728-6oyw5sqv 58 8 ) ) -RRB- cord-002728-6oyw5sqv 58 9 , , , cord-002728-6oyw5sqv 58 10 mucosal mucosal JJ cord-002728-6oyw5sqv 58 11 samples sample NNS cord-002728-6oyw5sqv 58 12 contain~1.2 contain~1.2 CD cord-002728-6oyw5sqv 58 13 9 9 CD cord-002728-6oyw5sqv 58 14 10 10 CD cord-002728-6oyw5sqv 58 15 9 9 CD cord-002728-6oyw5sqv 58 16 VLPs vlp NNS cord-002728-6oyw5sqv 58 17 / / SYM cord-002728-6oyw5sqv 58 18 biopsy biopsy NN cord-002728-6oyw5sqv 58 19 . . . cord-002728-6oyw5sqv 59 1 9 9 CD cord-002728-6oyw5sqv 59 2 VLPs vlp NNS cord-002728-6oyw5sqv 59 3 have have VBP cord-002728-6oyw5sqv 59 4 been be VBN cord-002728-6oyw5sqv 59 5 detected detect VBN cord-002728-6oyw5sqv 59 6 in in IN cord-002728-6oyw5sqv 59 7 caecal caecal JJ cord-002728-6oyw5sqv 59 8 contents content NNS cord-002728-6oyw5sqv 59 9 at at IN cord-002728-6oyw5sqv 59 10 10 10 CD cord-002728-6oyw5sqv 59 11 6 6 CD cord-002728-6oyw5sqv 59 12 /mL /mL . cord-002728-6oyw5sqv 59 13 using use VBG cord-002728-6oyw5sqv 59 14 TEM TEM NNP cord-002728-6oyw5sqv 59 15 10 10 CD cord-002728-6oyw5sqv 59 16 with with IN cord-002728-6oyw5sqv 59 17 faeces faece NNS cord-002728-6oyw5sqv 59 18 harbouring harbour VBG cord-002728-6oyw5sqv 59 19 10 10 CD cord-002728-6oyw5sqv 59 20 8 8 CD cord-002728-6oyw5sqv 59 21 -10 -10 CD cord-002728-6oyw5sqv 59 22 9 9 CD cord-002728-6oyw5sqv 59 23 VLPs vlp NNS cord-002728-6oyw5sqv 59 24 / / SYM cord-002728-6oyw5sqv 59 25 g g NN cord-002728-6oyw5sqv 59 26 wet wet JJ cord-002728-6oyw5sqv 59 27 weight weight NN cord-002728-6oyw5sqv 59 28 . . . cord-002728-6oyw5sqv 60 1 10 10 CD cord-002728-6oyw5sqv 60 2 , , , cord-002728-6oyw5sqv 60 3 11 11 CD cord-002728-6oyw5sqv 60 4 In in IN cord-002728-6oyw5sqv 60 5 all all DT cord-002728-6oyw5sqv 60 6 GI GI NNP cord-002728-6oyw5sqv 60 7 contents content NNS cord-002728-6oyw5sqv 60 8 examined examine VBN cord-002728-6oyw5sqv 60 9 to to IN cord-002728-6oyw5sqv 60 10 date date NN cord-002728-6oyw5sqv 60 11 by by IN cord-002728-6oyw5sqv 60 12 microscopy microscopy NNS cord-002728-6oyw5sqv 60 13 , , , cord-002728-6oyw5sqv 60 14 the the DT cord-002728-6oyw5sqv 60 15 overwhelming overwhelming JJ cord-002728-6oyw5sqv 60 16 majority majority NN cord-002728-6oyw5sqv 60 17 of of IN cord-002728-6oyw5sqv 60 18 VLPs vlp NNS cord-002728-6oyw5sqv 60 19 have have VBP cord-002728-6oyw5sqv 60 20 been be VBN cord-002728-6oyw5sqv 60 21 phages phage NNS cord-002728-6oyw5sqv 60 22 of of IN cord-002728-6oyw5sqv 60 23 the the DT cord-002728-6oyw5sqv 60 24 order order NN cord-002728-6oyw5sqv 61 1 Caudovirales Caudovirales NNP cord-002728-6oyw5sqv 61 2 , , , cord-002728-6oyw5sqv 61 3 with with IN cord-002728-6oyw5sqv 61 4 the the DT cord-002728-6oyw5sqv 61 5 human human JJ cord-002728-6oyw5sqv 61 6 GI GI NNP cord-002728-6oyw5sqv 61 7 tract tract NN cord-002728-6oyw5sqv 61 8 estimated estimate VBN cord-002728-6oyw5sqv 61 9 to to TO cord-002728-6oyw5sqv 61 10 harbour harbour VB cord-002728-6oyw5sqv 61 11 10 10 CD cord-002728-6oyw5sqv 61 12 15 15 CD cord-002728-6oyw5sqv 61 13 phages phage NNS cord-002728-6oyw5sqv 61 14 in in IN cord-002728-6oyw5sqv 61 15 total total NN cord-002728-6oyw5sqv 61 16 . . . cord-002728-6oyw5sqv 62 1 3 3 CD cord-002728-6oyw5sqv 62 2 , , , cord-002728-6oyw5sqv 62 3 9 9 CD cord-002728-6oyw5sqv 62 4 , , , cord-002728-6oyw5sqv 62 5 10 10 CD cord-002728-6oyw5sqv 62 6 , , , cord-002728-6oyw5sqv 62 7 12 12 CD cord-002728-6oyw5sqv 63 1 The the DT cord-002728-6oyw5sqv 63 2 order order NN cord-002728-6oyw5sqv 64 1 Caudovirales Caudovirales NNP cord-002728-6oyw5sqv 64 2 encompasses encompass VBZ cord-002728-6oyw5sqv 64 3 most most RBS cord-002728-6oyw5sqv 64 4 known know VBN cord-002728-6oyw5sqv 64 5 phages phage NNS cord-002728-6oyw5sqv 64 6 ( ( -LRB- cord-002728-6oyw5sqv 64 7 Figure figure NN cord-002728-6oyw5sqv 64 8 2 2 CD cord-002728-6oyw5sqv 64 9 ) ) -RRB- cord-002728-6oyw5sqv 64 10 , , , cord-002728-6oyw5sqv 64 11 comprising comprise VBG cord-002728-6oyw5sqv 64 12 the the DT cord-002728-6oyw5sqv 64 13 families family NNS cord-002728-6oyw5sqv 64 14 _SP cord-002728-6oyw5sqv 64 15 The the DT cord-002728-6oyw5sqv 64 16 only only JJ cord-002728-6oyw5sqv 64 17 reliable reliable JJ cord-002728-6oyw5sqv 64 18 molecular molecular JJ cord-002728-6oyw5sqv 64 19 method method NN cord-002728-6oyw5sqv 64 20 currently currently RB cord-002728-6oyw5sqv 64 21 available available JJ cord-002728-6oyw5sqv 64 22 for for IN cord-002728-6oyw5sqv 64 23 routine routine JJ cord-002728-6oyw5sqv 64 24 surveys survey NNS cord-002728-6oyw5sqv 64 25 of of IN cord-002728-6oyw5sqv 64 26 the the DT cord-002728-6oyw5sqv 64 27 human human JJ cord-002728-6oyw5sqv 64 28 virome virome NNP cord-002728-6oyw5sqv 64 29 is be VBZ cord-002728-6oyw5sqv 64 30 metagenomics metagenomic NNS cord-002728-6oyw5sqv 64 31 . . . cord-002728-6oyw5sqv 65 1 Metagenomics Metagenomics NNP cord-002728-6oyw5sqv 65 2 is be VBZ cord-002728-6oyw5sqv 65 3 a a DT cord-002728-6oyw5sqv 65 4 culture culture NN cord-002728-6oyw5sqv 65 5 - - HYPH cord-002728-6oyw5sqv 65 6 independent independent JJ cord-002728-6oyw5sqv 65 7 , , , cord-002728-6oyw5sqv 65 8 molecular molecular JJ cord-002728-6oyw5sqv 65 9 - - HYPH cord-002728-6oyw5sqv 65 10 based base VBN cord-002728-6oyw5sqv 65 11 approach approach NN cord-002728-6oyw5sqv 65 12 that that WDT cord-002728-6oyw5sqv 65 13 allows allow VBZ cord-002728-6oyw5sqv 65 14 functional functional JJ cord-002728-6oyw5sqv 65 15 and and CC cord-002728-6oyw5sqv 65 16 sequence sequence NN cord-002728-6oyw5sqv 65 17 - - HYPH cord-002728-6oyw5sqv 65 18 based base VBN cord-002728-6oyw5sqv 65 19 analyses analysis NNS cord-002728-6oyw5sqv 65 20 of of IN cord-002728-6oyw5sqv 65 21 the the DT cord-002728-6oyw5sqv 65 22 collective collective JJ cord-002728-6oyw5sqv 65 23 microbial microbial JJ cord-002728-6oyw5sqv 65 24 genomes genome NNS cord-002728-6oyw5sqv 65 25 contained contain VBN cord-002728-6oyw5sqv 65 26 in in IN cord-002728-6oyw5sqv 65 27 an an DT cord-002728-6oyw5sqv 65 28 environmental environmental JJ cord-002728-6oyw5sqv 65 29 sample sample NN cord-002728-6oyw5sqv 65 30 , , , cord-002728-6oyw5sqv 65 31 providing provide VBG cord-002728-6oyw5sqv 65 32 a a DT cord-002728-6oyw5sqv 65 33 powerful powerful JJ cord-002728-6oyw5sqv 65 34 approach approach NN cord-002728-6oyw5sqv 65 35 for for IN cord-002728-6oyw5sqv 65 36 exploring explore VBG cord-002728-6oyw5sqv 65 37 the the DT cord-002728-6oyw5sqv 65 38 ecology ecology NN cord-002728-6oyw5sqv 65 39 of of IN cord-002728-6oyw5sqv 65 40 complex complex JJ cord-002728-6oyw5sqv 65 41 microbial microbial JJ cord-002728-6oyw5sqv 65 42 communities community NNS cord-002728-6oyw5sqv 65 43 . . . cord-002728-6oyw5sqv 66 1 14 14 CD cord-002728-6oyw5sqv 67 1 It -PRON- PRP cord-002728-6oyw5sqv 67 2 has have VBZ cord-002728-6oyw5sqv 67 3 been be VBN cord-002728-6oyw5sqv 67 4 used use VBN cord-002728-6oyw5sqv 67 5 to to TO cord-002728-6oyw5sqv 67 6 examine examine VB cord-002728-6oyw5sqv 67 7 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 67 8 communities community NNS cord-002728-6oyw5sqv 67 9 associated associate VBN cord-002728-6oyw5sqv 67 10 with with IN cord-002728-6oyw5sqv 67 11 the the DT cord-002728-6oyw5sqv 67 12 human human JJ cord-002728-6oyw5sqv 67 13 gut gut NN cord-002728-6oyw5sqv 67 14 microbiome microbiome NN cord-002728-6oyw5sqv 67 15 in in IN cord-002728-6oyw5sqv 67 16 health health NN cord-002728-6oyw5sqv 67 17 and and CC cord-002728-6oyw5sqv 67 18 disease disease NN cord-002728-6oyw5sqv 67 19 , , , cord-002728-6oyw5sqv 67 20 [ [ -LRB- cord-002728-6oyw5sqv 67 21 15 15 CD cord-002728-6oyw5sqv 67 22 ] ] -RRB- cord-002728-6oyw5sqv 67 23 [ [ -LRB- cord-002728-6oyw5sqv 67 24 16 16 CD cord-002728-6oyw5sqv 67 25 ] ] -RRB- cord-002728-6oyw5sqv 67 26 [ [ -LRB- cord-002728-6oyw5sqv 67 27 17 17 CD cord-002728-6oyw5sqv 67 28 ] ] -RRB- cord-002728-6oyw5sqv 67 29 [ [ -LRB- cord-002728-6oyw5sqv 67 30 18 18 CD cord-002728-6oyw5sqv 67 31 ] ] -RRB- cord-002728-6oyw5sqv 67 32 and and CC cord-002728-6oyw5sqv 67 33 to to TO cord-002728-6oyw5sqv 67 34 examine examine VB cord-002728-6oyw5sqv 67 35 viromes virome NNS cord-002728-6oyw5sqv 67 36 associated associate VBN cord-002728-6oyw5sqv 67 37 with with IN cord-002728-6oyw5sqv 67 38 different different JJ cord-002728-6oyw5sqv 67 39 regions region NNS cord-002728-6oyw5sqv 67 40 of of IN cord-002728-6oyw5sqv 67 41 the the DT cord-002728-6oyw5sqv 67 42 human human JJ cord-002728-6oyw5sqv 67 43 body body NN cord-002728-6oyw5sqv 67 44 ( ( -LRB- cord-002728-6oyw5sqv 67 45 Table Table NNP cord-002728-6oyw5sqv 67 46 S1 S1 NNP cord-002728-6oyw5sqv 67 47 ) ) -RRB- cord-002728-6oyw5sqv 67 48 . . . cord-002728-6oyw5sqv 68 1 A a DT cord-002728-6oyw5sqv 68 2 protocol protocol NN cord-002728-6oyw5sqv 68 3 involving involve VBG cord-002728-6oyw5sqv 68 4 homogenisation homogenisation NN cord-002728-6oyw5sqv 68 5 of of IN cord-002728-6oyw5sqv 68 6 faeces faece NNS cord-002728-6oyw5sqv 68 7 in in IN cord-002728-6oyw5sqv 68 8 buffer buffer NN cord-002728-6oyw5sqv 68 9 , , , cord-002728-6oyw5sqv 68 10 centrifugation centrifugation NN cord-002728-6oyw5sqv 68 11 ( ( -LRB- cord-002728-6oyw5sqv 68 12 to to TO cord-002728-6oyw5sqv 68 13 remove remove VB cord-002728-6oyw5sqv 68 14 cell cell NN cord-002728-6oyw5sqv 68 15 debris debris NN cord-002728-6oyw5sqv 68 16 ) ) -RRB- cord-002728-6oyw5sqv 68 17 , , , cord-002728-6oyw5sqv 68 18 tangential tangential JJ cord-002728-6oyw5sqv 68 19 flow flow NN cord-002728-6oyw5sqv 68 20 filtration filtration NN cord-002728-6oyw5sqv 68 21 ( ( -LRB- cord-002728-6oyw5sqv 68 22 TFF TFF NNP cord-002728-6oyw5sqv 68 23 ) ) -RRB- cord-002728-6oyw5sqv 68 24 ( ( -LRB- cord-002728-6oyw5sqv 68 25 to to TO cord-002728-6oyw5sqv 68 26 concentrate concentrate VB cord-002728-6oyw5sqv 68 27 large large JJ cord-002728-6oyw5sqv 68 28 - - HYPH cord-002728-6oyw5sqv 68 29 volume volume NN cord-002728-6oyw5sqv 68 30 samples sample NNS cord-002728-6oyw5sqv 68 31 and and CC cord-002728-6oyw5sqv 68 32 isolate isolate VBP cord-002728-6oyw5sqv 68 33 VLPs vlp NNS cord-002728-6oyw5sqv 68 34 ) ) -RRB- cord-002728-6oyw5sqv 68 35 , , , cord-002728-6oyw5sqv 68 36 ultracentrifugation ultracentrifugation NN cord-002728-6oyw5sqv 68 37 and and CC cord-002728-6oyw5sqv 68 38 metagenomic metagenomic NNP cord-002728-6oyw5sqv 68 39 reconstruction reconstruction NN cord-002728-6oyw5sqv 68 40 was be VBD cord-002728-6oyw5sqv 68 41 used use VBN cord-002728-6oyw5sqv 68 42 to to TO cord-002728-6oyw5sqv 68 43 characterise characterise VB cord-002728-6oyw5sqv 68 44 the the DT cord-002728-6oyw5sqv 68 45 first first JJ cord-002728-6oyw5sqv 68 46 human human JJ cord-002728-6oyw5sqv 68 47 faecal faecal JJ cord-002728-6oyw5sqv 68 48 virome virome NN cord-002728-6oyw5sqv 68 49 . . . cord-002728-6oyw5sqv 69 1 19 19 CD cord-002728-6oyw5sqv 70 1 However however RB cord-002728-6oyw5sqv 70 2 , , , cord-002728-6oyw5sqv 70 3 recent recent JJ cord-002728-6oyw5sqv 70 4 improvements improvement NNS cord-002728-6oyw5sqv 70 5 in in IN cord-002728-6oyw5sqv 70 6 recovery recovery NN cord-002728-6oyw5sqv 70 7 methods method NNS cord-002728-6oyw5sqv 70 8 give give VBP cord-002728-6oyw5sqv 70 9 the the DT cord-002728-6oyw5sqv 70 10 potential potential NN cord-002728-6oyw5sqv 70 11 to to TO cord-002728-6oyw5sqv 70 12 characterise characterise VB cord-002728-6oyw5sqv 70 13 human human JJ cord-002728-6oyw5sqv 70 14 - - HYPH cord-002728-6oyw5sqv 70 15 associated associate VBN cord-002728-6oyw5sqv 70 16 VLP VLP NNP cord-002728-6oyw5sqv 70 17 assemblages assemblage NNS cord-002728-6oyw5sqv 70 18 at at IN cord-002728-6oyw5sqv 70 19 the the DT cord-002728-6oyw5sqv 70 20 molecular molecular JJ cord-002728-6oyw5sqv 70 21 level level NN cord-002728-6oyw5sqv 70 22 in in IN cord-002728-6oyw5sqv 70 23 greater great JJR cord-002728-6oyw5sqv 70 24 detail detail NN cord-002728-6oyw5sqv 70 25 than than IN cord-002728-6oyw5sqv 70 26 ever ever RB cord-002728-6oyw5sqv 70 27 before before RB cord-002728-6oyw5sqv 70 28 ( ( -LRB- cord-002728-6oyw5sqv 70 29 Sequences sequence NNS cord-002728-6oyw5sqv 70 30 associated associate VBN cord-002728-6oyw5sqv 70 31 with with IN cord-002728-6oyw5sqv 70 32 this this DT cord-002728-6oyw5sqv 70 33 phage phage NN cord-002728-6oyw5sqv 70 34 were be VBD cord-002728-6oyw5sqv 70 35 not not RB cord-002728-6oyw5sqv 70 36 found find VBN cord-002728-6oyw5sqv 70 37 in in IN cord-002728-6oyw5sqv 70 38 American american JJ cord-002728-6oyw5sqv 70 39 gut gut NN cord-002728-6oyw5sqv 70 40 - - HYPH cord-002728-6oyw5sqv 70 41 associated associate VBN cord-002728-6oyw5sqv 70 42 datasets dataset NNS cord-002728-6oyw5sqv 70 43 ( ( -LRB- cord-002728-6oyw5sqv 70 44 metagenome metagenome NNP cord-002728-6oyw5sqv 70 45 or or CC cord-002728-6oyw5sqv 70 46 virome virome NNP cord-002728-6oyw5sqv 70 47 ) ) -RRB- cord-002728-6oyw5sqv 70 48 , , , cord-002728-6oyw5sqv 70 49 suggesting suggest VBG cord-002728-6oyw5sqv 70 50 geographical geographical JJ cord-002728-6oyw5sqv 70 51 variation variation NN cord-002728-6oyw5sqv 70 52 in in IN cord-002728-6oyw5sqv 70 53 distribution distribution NN cord-002728-6oyw5sqv 70 54 of of IN cord-002728-6oyw5sqv 70 55 gut gut NN cord-002728-6oyw5sqv 70 56 - - HYPH cord-002728-6oyw5sqv 70 57 associated associate VBN cord-002728-6oyw5sqv 70 58 phages phage NNS cord-002728-6oyw5sqv 70 59 . . . cord-002728-6oyw5sqv 71 1 7 7 CD cord-002728-6oyw5sqv 72 1 Using use VBG cord-002728-6oyw5sqv 72 2 a a DT cord-002728-6oyw5sqv 72 3 similar similar JJ cord-002728-6oyw5sqv 72 4 metagenomic metagenomic NN cord-002728-6oyw5sqv 72 5 mining mining NN cord-002728-6oyw5sqv 72 6 approach approach NN cord-002728-6oyw5sqv 72 7 but but CC cord-002728-6oyw5sqv 72 8 with with IN cord-002728-6oyw5sqv 72 9 major major JJ cord-002728-6oyw5sqv 72 10 capsid capsid NN cord-002728-6oyw5sqv 72 11 protein protein NN cord-002728-6oyw5sqv 72 12 VP1 vp1 NN cord-002728-6oyw5sqv 72 13 specific specific JJ cord-002728-6oyw5sqv 72 14 for for IN cord-002728-6oyw5sqv 72 15 the the DT cord-002728-6oyw5sqv 72 16 ssDNA ssdna JJ cord-002728-6oyw5sqv 72 17 phage phage NN cord-002728-6oyw5sqv 72 18 family family NN cord-002728-6oyw5sqv 72 19 Microviridae Microviridae NNP cord-002728-6oyw5sqv 72 20 , , , cord-002728-6oyw5sqv 72 21 members member NNS cord-002728-6oyw5sqv 72 22 of of IN cord-002728-6oyw5sqv 72 23 the the DT cord-002728-6oyw5sqv 72 24 subfamilies subfamily NNS cord-002728-6oyw5sqv 72 25 Gokushovirinae Gokushovirinae NNP cord-002728-6oyw5sqv 72 26 , , , cord-002728-6oyw5sqv 72 27 Alpnavirinae Alpnavirinae NNP cord-002728-6oyw5sqv 72 28 and and CC cord-002728-6oyw5sqv 72 29 Pichovirinae Pichovirinae NNP cord-002728-6oyw5sqv 72 30 were be VBD cord-002728-6oyw5sqv 72 31 detected detect VBN cord-002728-6oyw5sqv 72 32 in in IN cord-002728-6oyw5sqv 72 33 faecal faecal JJ cord-002728-6oyw5sqv 72 34 metagenomes metagenome NNS cord-002728-6oyw5sqv 72 35 . . . cord-002728-6oyw5sqv 73 1 24 24 CD cord-002728-6oyw5sqv 74 1 By by IN cord-002728-6oyw5sqv 74 2 using use VBG cord-002728-6oyw5sqv 74 3 phage phage NN cord-002728-6oyw5sqv 74 4 genome genome NN cord-002728-6oyw5sqv 74 5 signature signature NN cord-002728-6oyw5sqv 74 6 - - HYPH cord-002728-6oyw5sqv 74 7 based base VBN cord-002728-6oyw5sqv 74 8 recovery recovery NN cord-002728-6oyw5sqv 74 9 with with IN cord-002728-6oyw5sqv 74 10 metagenomes metagenomes NNP cord-002728-6oyw5sqv 74 11 , , , cord-002728-6oyw5sqv 74 12 several several JJ cord-002728-6oyw5sqv 74 13 ( ( -LRB- cord-002728-6oyw5sqv 74 14 predominantly predominantly RB cord-002728-6oyw5sqv 74 15 temperate temperate JJ cord-002728-6oyw5sqv 74 16 ) ) -RRB- cord-002728-6oyw5sqv 74 17 potential potential JJ cord-002728-6oyw5sqv 74 18 gut gut NN cord-002728-6oyw5sqv 74 19 - - HYPH cord-002728-6oyw5sqv 74 20 specific specific JJ cord-002728-6oyw5sqv 74 21 phages phage NNS cord-002728-6oyw5sqv 74 22 infecting infect VBG cord-002728-6oyw5sqv 74 23 members member NNS cord-002728-6oyw5sqv 74 24 of of IN cord-002728-6oyw5sqv 74 25 the the DT cord-002728-6oyw5sqv 74 26 order order NN cord-002728-6oyw5sqv 74 27 Bacteroidales Bacteroidales NNPS cord-002728-6oyw5sqv 74 28 were be VBD cord-002728-6oyw5sqv 74 29 identified identify VBN cord-002728-6oyw5sqv 74 30 . . . cord-002728-6oyw5sqv 75 1 21 21 CD cord-002728-6oyw5sqv 76 1 This this DT cord-002728-6oyw5sqv 76 2 alignment alignment NN cord-002728-6oyw5sqv 76 3 - - HYPH cord-002728-6oyw5sqv 76 4 free free JJ cord-002728-6oyw5sqv 76 5 approach approach NN cord-002728-6oyw5sqv 76 6 was be VBD cord-002728-6oyw5sqv 76 7 able able JJ cord-002728-6oyw5sqv 76 8 to to TO cord-002728-6oyw5sqv 76 9 resolve resolve VB cord-002728-6oyw5sqv 76 10 phage phage NN cord-002728-6oyw5sqv 76 11 sequences sequence NNS cord-002728-6oyw5sqv 76 12 not not RB cord-002728-6oyw5sqv 76 13 readily readily RB cord-002728-6oyw5sqv 76 14 detected detect VBN cord-002728-6oyw5sqv 76 15 by by IN cord-002728-6oyw5sqv 76 16 conventional conventional JJ cord-002728-6oyw5sqv 76 17 alignment alignment NN cord-002728-6oyw5sqv 76 18 - - HYPH cord-002728-6oyw5sqv 76 19 driven drive VBN cord-002728-6oyw5sqv 76 20 approaches approach NNS cord-002728-6oyw5sqv 76 21 . . . cord-002728-6oyw5sqv 77 1 The the DT cord-002728-6oyw5sqv 77 2 main main JJ cord-002728-6oyw5sqv 77 3 limitation limitation NN cord-002728-6oyw5sqv 77 4 of of IN cord-002728-6oyw5sqv 77 5 this this DT cord-002728-6oyw5sqv 77 6 method method NN cord-002728-6oyw5sqv 77 7 is be VBZ cord-002728-6oyw5sqv 77 8 the the DT cord-002728-6oyw5sqv 77 9 lack lack NN cord-002728-6oyw5sqv 77 10 of of IN cord-002728-6oyw5sqv 77 11 available available JJ cord-002728-6oyw5sqv 77 12 genome genome NN cord-002728-6oyw5sqv 77 13 sequences sequence NNS cord-002728-6oyw5sqv 77 14 from from IN cord-002728-6oyw5sqv 77 15 isolated isolate VBN cord-002728-6oyw5sqv 77 16 phages phage NNS cord-002728-6oyw5sqv 77 17 , , , cord-002728-6oyw5sqv 77 18 as as IN cord-002728-6oyw5sqv 77 19 " " `` cord-002728-6oyw5sqv 77 20 driver driver NN cord-002728-6oyw5sqv 77 21 sequences sequence NNS cord-002728-6oyw5sqv 77 22 " " '' cord-002728-6oyw5sqv 77 23 are be VBP cord-002728-6oyw5sqv 77 24 required require VBN cord-002728-6oyw5sqv 77 25 to to TO cord-002728-6oyw5sqv 77 26 provide provide VB cord-002728-6oyw5sqv 77 27 baseline baseline JJ cord-002728-6oyw5sqv 77 28 information information NN cord-002728-6oyw5sqv 77 29 upon upon IN cord-002728-6oyw5sqv 77 30 which which WDT cord-002728-6oyw5sqv 77 31 inferences inference NNS cord-002728-6oyw5sqv 77 32 can can MD cord-002728-6oyw5sqv 77 33 be be VB cord-002728-6oyw5sqv 77 34 made make VBN cord-002728-6oyw5sqv 77 35 regarding regard VBG cord-002728-6oyw5sqv 77 36 sequence sequence NN cord-002728-6oyw5sqv 77 37 data datum NNS cord-002728-6oyw5sqv 77 38 and and CC cord-002728-6oyw5sqv 77 39 host host NN cord-002728-6oyw5sqv 77 40 phylogeny phylogeny NN cord-002728-6oyw5sqv 77 41 ( ( -LRB- cord-002728-6oyw5sqv 77 42 only only RB cord-002728-6oyw5sqv 77 43 four four CD cord-002728-6oyw5sqv 77 44 such such JJ cord-002728-6oyw5sqv 77 45 " " `` cord-002728-6oyw5sqv 77 46 driver driver NN cord-002728-6oyw5sqv 77 47 sequences sequence NNS cord-002728-6oyw5sqv 77 48 " " '' cord-002728-6oyw5sqv 77 49 were be VBD cord-002728-6oyw5sqv 77 50 required require VBN cord-002728-6oyw5sqv 77 51 in in IN cord-002728-6oyw5sqv 77 52 the the DT cord-002728-6oyw5sqv 77 53 Bacteroidales Bacteroidales NNP cord-002728-6oyw5sqv 77 54 study study NN cord-002728-6oyw5sqv 77 55 ) ) -RRB- cord-002728-6oyw5sqv 77 56 . . . cord-002728-6oyw5sqv 78 1 21 21 CD cord-002728-6oyw5sqv 79 1 Using use VBG cord-002728-6oyw5sqv 79 2 co co JJ cord-002728-6oyw5sqv 79 3 - - JJ cord-002728-6oyw5sqv 79 4 occurrence occurrence JJ cord-002728-6oyw5sqv 79 5 profiling profiling NN cord-002728-6oyw5sqv 79 6 , , , cord-002728-6oyw5sqv 79 7 crAssphage crAssphage NNP cord-002728-6oyw5sqv 79 8 was be VBD cord-002728-6oyw5sqv 79 9 identified identify VBN cord-002728-6oyw5sqv 79 10 in in IN cord-002728-6oyw5sqv 79 11 publicly publicly RB cord-002728-6oyw5sqv 79 12 available available JJ cord-002728-6oyw5sqv 79 13 metagenomes metagenomes NNP cord-002728-6oyw5sqv 79 14 , , , cord-002728-6oyw5sqv 79 15 and and CC cord-002728-6oyw5sqv 79 16 by by IN cord-002728-6oyw5sqv 79 17 CRISPR CRISPR NNP cord-002728-6oyw5sqv 79 18 analysis analysis NN cord-002728-6oyw5sqv 79 19 and and CC cord-002728-6oyw5sqv 79 20 co co NN cord-002728-6oyw5sqv 79 21 - - JJ cord-002728-6oyw5sqv 79 22 occurrence occurrence JJ cord-002728-6oyw5sqv 79 23 profiling profiling NN cord-002728-6oyw5sqv 79 24 predicted predict VBN cord-002728-6oyw5sqv 79 25 to to TO cord-002728-6oyw5sqv 79 26 infect infect VB cord-002728-6oyw5sqv 79 27 Bacteroides Bacteroides NNP cord-002728-6oyw5sqv 79 28 or or CC cord-002728-6oyw5sqv 79 29 Prevotella Prevotella NNP cord-002728-6oyw5sqv 79 30 spp spp NNS cord-002728-6oyw5sqv 79 31 . . . cord-002728-6oyw5sqv 80 1 22 22 CD cord-002728-6oyw5sqv 80 2 Assembly assembly NN cord-002728-6oyw5sqv 80 3 of of IN cord-002728-6oyw5sqv 80 4 sequence sequence NN cord-002728-6oyw5sqv 80 5 data datum NNS cord-002728-6oyw5sqv 80 6 from from IN cord-002728-6oyw5sqv 80 7 four four CD cord-002728-6oyw5sqv 80 8 deep deep RB cord-002728-6oyw5sqv 80 9 - - HYPH cord-002728-6oyw5sqv 80 10 sequenced sequence VBN cord-002728-6oyw5sqv 80 11 DNA dna NN cord-002728-6oyw5sqv 80 12 viromes virome NNS cord-002728-6oyw5sqv 80 13 ( ( -LRB- cord-002728-6oyw5sqv 80 14 8.1 8.1 CD cord-002728-6oyw5sqv 80 15 Gb Gb NNP cord-002728-6oyw5sqv 80 16 sequence sequence NN cord-002728-6oyw5sqv 80 17 data datum NNS cord-002728-6oyw5sqv 80 18 in in IN cord-002728-6oyw5sqv 80 19 total total NN cord-002728-6oyw5sqv 80 20 ) ) -RRB- cord-002728-6oyw5sqv 80 21 from from IN cord-002728-6oyw5sqv 80 22 two two CD cord-002728-6oyw5sqv 80 23 healthy healthy JJ cord-002728-6oyw5sqv 80 24 individuals individual NNS cord-002728-6oyw5sqv 80 25 led lead VBD cord-002728-6oyw5sqv 80 26 to to IN cord-002728-6oyw5sqv 80 27 recovery recovery NN cord-002728-6oyw5sqv 80 28 of of IN cord-002728-6oyw5sqv 80 29 4301 4301 CD cord-002728-6oyw5sqv 80 30 contigs contigs NNP cord-002728-6oyw5sqv 80 31 , , , cord-002728-6oyw5sqv 80 32 representing represent VBG cord-002728-6oyw5sqv 80 33 72 72 CD cord-002728-6oyw5sqv 80 34 complete complete JJ cord-002728-6oyw5sqv 80 35 phage phage NN cord-002728-6oyw5sqv 80 36 genomes genome NNS cord-002728-6oyw5sqv 80 37 plus plus CC cord-002728-6oyw5sqv 80 38 potentially potentially RB cord-002728-6oyw5sqv 80 39 complete complete JJ cord-002728-6oyw5sqv 80 40 and and CC cord-002728-6oyw5sqv 80 41 partial partial JJ cord-002728-6oyw5sqv 80 42 phage phage NN cord-002728-6oyw5sqv 80 43 genomes genome NNS cord-002728-6oyw5sqv 80 44 . . . cord-002728-6oyw5sqv 81 1 28 28 CD cord-002728-6oyw5sqv 81 2 mapped map VBD cord-002728-6oyw5sqv 81 3 to to IN cord-002728-6oyw5sqv 81 4 160 160 CD cord-002728-6oyw5sqv 81 5 contigs contig NNS cord-002728-6oyw5sqv 81 6 . . . cord-002728-6oyw5sqv 82 1 A a DT cord-002728-6oyw5sqv 82 2 consortium consortium NN cord-002728-6oyw5sqv 82 3 of of IN cord-002728-6oyw5sqv 82 4 155 155 CD cord-002728-6oyw5sqv 82 5 phages phage NNS cord-002728-6oyw5sqv 82 6 contributed contribute VBD cord-002728-6oyw5sqv 82 7 to to IN cord-002728-6oyw5sqv 82 8 the the DT cord-002728-6oyw5sqv 82 9 " " `` cord-002728-6oyw5sqv 82 10 healthy healthy JJ cord-002728-6oyw5sqv 82 11 gut gut NN cord-002728-6oyw5sqv 82 12 phageome phageome NN cord-002728-6oyw5sqv 82 13 " " '' cord-002728-6oyw5sqv 82 14 ( ( -LRB- cord-002728-6oyw5sqv 82 15 HGP HGP NNP cord-002728-6oyw5sqv 82 16 ) ) -RRB- cord-002728-6oyw5sqv 82 17 , , , cord-002728-6oyw5sqv 82 18 though though IN cord-002728-6oyw5sqv 82 19 only only RB cord-002728-6oyw5sqv 82 20 23 23 CD cord-002728-6oyw5sqv 82 21 phages phage NNS cord-002728-6oyw5sqv 82 22 were be VBD cord-002728-6oyw5sqv 82 23 present present JJ cord-002728-6oyw5sqv 82 24 in in IN cord-002728-6oyw5sqv 82 25 > > $ cord-002728-6oyw5sqv 82 26 50 50 CD cord-002728-6oyw5sqv 82 27 % % NN cord-002728-6oyw5sqv 82 28 of of IN cord-002728-6oyw5sqv 82 29 samples sample NNS cord-002728-6oyw5sqv 82 30 ( ( -LRB- cord-002728-6oyw5sqv 82 31 " " `` cord-002728-6oyw5sqv 82 32 core core NN cord-002728-6oyw5sqv 82 33 " " '' cord-002728-6oyw5sqv 82 34 phages phage NNS cord-002728-6oyw5sqv 82 35 , , , cord-002728-6oyw5sqv 82 36 including include VBG cord-002728-6oyw5sqv 82 37 crAssphage crassphage NN cord-002728-6oyw5sqv 82 38 and and CC cord-002728-6oyw5sqv 82 39 nine nine CD cord-002728-6oyw5sqv 82 40 other other JJ cord-002728-6oyw5sqv 82 41 complete complete JJ cord-002728-6oyw5sqv 82 42 genomes genome NNS cord-002728-6oyw5sqv 82 43 ) ) -RRB- cord-002728-6oyw5sqv 82 44 , , , cord-002728-6oyw5sqv 82 45 and and CC cord-002728-6oyw5sqv 82 46 132 132 CD cord-002728-6oyw5sqv 82 47 were be VBD cord-002728-6oyw5sqv 82 48 present present JJ cord-002728-6oyw5sqv 82 49 in in IN cord-002728-6oyw5sqv 82 50 20%-50 20%-50 CD cord-002728-6oyw5sqv 82 51 % % NN cord-002728-6oyw5sqv 82 52 of of IN cord-002728-6oyw5sqv 82 53 samples sample NNS cord-002728-6oyw5sqv 82 54 ( ( -LRB- cord-002728-6oyw5sqv 82 55 " " `` cord-002728-6oyw5sqv 82 56 common common JJ cord-002728-6oyw5sqv 82 57 " " '' cord-002728-6oyw5sqv 82 58 phages phage NNS cord-002728-6oyw5sqv 82 59 ) ) -RRB- cord-002728-6oyw5sqv 82 60 ; ; : cord-002728-6oyw5sqv 82 61 1679 1679 CD cord-002728-6oyw5sqv 82 62 were be VBD cord-002728-6oyw5sqv 82 63 present present JJ cord-002728-6oyw5sqv 82 64 in in IN cord-002728-6oyw5sqv 82 65 2%-19 2%-19 CD cord-002728-6oyw5sqv 82 66 % % NN cord-002728-6oyw5sqv 82 67 ( ( -LRB- cord-002728-6oyw5sqv 82 68 " " `` cord-002728-6oyw5sqv 82 69 low low JJ cord-002728-6oyw5sqv 82 70 overlap overlap NN cord-002728-6oyw5sqv 82 71 " " '' cord-002728-6oyw5sqv 82 72 phages phage NNS cord-002728-6oyw5sqv 82 73 ) ) -RRB- cord-002728-6oyw5sqv 82 74 . . . cord-002728-6oyw5sqv 83 1 The the DT cord-002728-6oyw5sqv 83 2 HGP HGP NNP cord-002728-6oyw5sqv 83 3 represented represent VBD cord-002728-6oyw5sqv 83 4 only only RB cord-002728-6oyw5sqv 83 5 4 4 CD cord-002728-6oyw5sqv 83 6 % % NN cord-002728-6oyw5sqv 83 7 of of IN cord-002728-6oyw5sqv 83 8 the the DT cord-002728-6oyw5sqv 83 9 total total JJ cord-002728-6oyw5sqv 83 10 phage phage NN cord-002728-6oyw5sqv 83 11 community community NN cord-002728-6oyw5sqv 83 12 , , , cord-002728-6oyw5sqv 83 13 with with IN cord-002728-6oyw5sqv 83 14 the the DT cord-002728-6oyw5sqv 83 15 expectation expectation NN cord-002728-6oyw5sqv 83 16 that that IN cord-002728-6oyw5sqv 83 17 the the DT cord-002728-6oyw5sqv 83 18 HGP HGP NNP cord-002728-6oyw5sqv 83 19 will will MD cord-002728-6oyw5sqv 83 20 increase increase VB cord-002728-6oyw5sqv 83 21 in in IN cord-002728-6oyw5sqv 83 22 size size NN cord-002728-6oyw5sqv 83 23 by by IN cord-002728-6oyw5sqv 83 24 analysing analyse VBG cord-002728-6oyw5sqv 83 25 additional additional JJ cord-002728-6oyw5sqv 83 26 healthy healthy JJ cord-002728-6oyw5sqv 83 27 individuals individual NNS cord-002728-6oyw5sqv 83 28 using use VBG cord-002728-6oyw5sqv 83 29 deep deep JJ cord-002728-6oyw5sqv 83 30 sequencing sequencing NN cord-002728-6oyw5sqv 83 31 . . . cord-002728-6oyw5sqv 84 1 28 28 CD cord-002728-6oyw5sqv 85 1 Although although IN cord-002728-6oyw5sqv 85 2 it -PRON- PRP cord-002728-6oyw5sqv 85 3 has have VBZ cord-002728-6oyw5sqv 85 4 been be VBN cord-002728-6oyw5sqv 85 5 proposed propose VBN cord-002728-6oyw5sqv 85 6 the the DT cord-002728-6oyw5sqv 85 7 HGP HGP NNP cord-002728-6oyw5sqv 85 8 may may MD cord-002728-6oyw5sqv 85 9 play play VB cord-002728-6oyw5sqv 85 10 a a DT cord-002728-6oyw5sqv 85 11 role role NN cord-002728-6oyw5sqv 85 12 in in IN cord-002728-6oyw5sqv 85 13 maintaining maintain VBG cord-002728-6oyw5sqv 85 14 and and CC cord-002728-6oyw5sqv 85 15 possibly possibly RB cord-002728-6oyw5sqv 85 16 restoring restore VBG cord-002728-6oyw5sqv 85 17 a a DT cord-002728-6oyw5sqv 85 18 dysbiotic dysbiotic JJ cord-002728-6oyw5sqv 85 19 microbiota microbiota NN cord-002728-6oyw5sqv 85 20 , , , cord-002728-6oyw5sqv 85 21 30 30 CD cord-002728-6oyw5sqv 85 22 ( ( -LRB- cord-002728-6oyw5sqv 85 23 Table Table NNP cord-002728-6oyw5sqv 85 24 S1 S1 NNP cord-002728-6oyw5sqv 85 25 ) ) -RRB- cord-002728-6oyw5sqv 85 26 . . . cord-002728-6oyw5sqv 86 1 Later later RB cord-002728-6oyw5sqv 86 2 work work VB cord-002728-6oyw5sqv 86 3 on on IN cord-002728-6oyw5sqv 86 4 oral oral JJ cord-002728-6oyw5sqv 86 5 and and CC cord-002728-6oyw5sqv 86 6 faecal faecal JJ cord-002728-6oyw5sqv 86 7 viromes virome NNS cord-002728-6oyw5sqv 86 8 of of IN cord-002728-6oyw5sqv 86 9 20 20 CD cord-002728-6oyw5sqv 86 10 individuals individual NNS cord-002728-6oyw5sqv 86 11 over over IN cord-002728-6oyw5sqv 86 12 a a DT cord-002728-6oyw5sqv 86 13 6-month 6-month CD cord-002728-6oyw5sqv 86 14 period period NN cord-002728-6oyw5sqv 86 15 confirmed confirm VBD cord-002728-6oyw5sqv 86 16 this this DT cord-002728-6oyw5sqv 86 17 , , , cord-002728-6oyw5sqv 86 18 demonstrating demonstrate VBG cord-002728-6oyw5sqv 86 19 phages phage NNS cord-002728-6oyw5sqv 86 20 were be VBD cord-002728-6oyw5sqv 86 21 persistent persistent JJ cord-002728-6oyw5sqv 86 22 in in IN cord-002728-6oyw5sqv 86 23 these these DT cord-002728-6oyw5sqv 86 24 viromes virome NNS cord-002728-6oyw5sqv 86 25 and and CC cord-002728-6oyw5sqv 86 26 readily readily RB cord-002728-6oyw5sqv 86 27 shared share VBN cord-002728-6oyw5sqv 86 28 among among IN cord-002728-6oyw5sqv 86 29 related related JJ cord-002728-6oyw5sqv 86 30 and and CC cord-002728-6oyw5sqv 86 31 unrelated unrelated JJ cord-002728-6oyw5sqv 86 32 members member NNS cord-002728-6oyw5sqv 86 33 of of IN cord-002728-6oyw5sqv 86 34 the the DT cord-002728-6oyw5sqv 86 35 same same JJ cord-002728-6oyw5sqv 86 36 household household NN cord-002728-6oyw5sqv 86 37 . . . cord-002728-6oyw5sqv 87 1 38 38 CD cord-002728-6oyw5sqv 87 2 Sharing sharing NN cord-002728-6oyw5sqv 87 3 of of IN cord-002728-6oyw5sqv 87 4 phages phage NNS cord-002728-6oyw5sqv 87 5 encoding encode VBG cord-002728-6oyw5sqv 87 6 virulence virulence NN cord-002728-6oyw5sqv 87 7 or or CC cord-002728-6oyw5sqv 87 8 antibiotic antibiotic NN cord-002728-6oyw5sqv 87 9 - - HYPH cord-002728-6oyw5sqv 87 10 resistance resistance NN cord-002728-6oyw5sqv 87 11 genes gene NNS cord-002728-6oyw5sqv 87 12 has have VBZ cord-002728-6oyw5sqv 87 13 implications implication NNS cord-002728-6oyw5sqv 87 14 for for IN cord-002728-6oyw5sqv 87 15 shaping shape VBG cord-002728-6oyw5sqv 87 16 of of IN cord-002728-6oyw5sqv 87 17 microbiomes microbiome NNS cord-002728-6oyw5sqv 87 18 of of IN cord-002728-6oyw5sqv 87 19 those those DT cord-002728-6oyw5sqv 87 20 in in IN cord-002728-6oyw5sqv 87 21 close close JJ cord-002728-6oyw5sqv 87 22 contact contact NN cord-002728-6oyw5sqv 87 23 with with IN cord-002728-6oyw5sqv 87 24 one one CD cord-002728-6oyw5sqv 87 25 another another DT cord-002728-6oyw5sqv 87 26 , , , cord-002728-6oyw5sqv 87 27 and and CC cord-002728-6oyw5sqv 87 28 warrants warrant NNS cord-002728-6oyw5sqv 87 29 further further JJ cord-002728-6oyw5sqv 87 30 study study NN cord-002728-6oyw5sqv 87 31 . . . cord-002728-6oyw5sqv 88 1 With with IN cord-002728-6oyw5sqv 88 2 respect respect NN cord-002728-6oyw5sqv 88 3 to to IN cord-002728-6oyw5sqv 88 4 antibiotic antibiotic JJ cord-002728-6oyw5sqv 88 5 - - HYPH cord-002728-6oyw5sqv 88 6 resistance resistance NN cord-002728-6oyw5sqv 88 7 genes gene NNS cord-002728-6oyw5sqv 88 8 , , , cord-002728-6oyw5sqv 88 9 their -PRON- PRP$ cord-002728-6oyw5sqv 88 10 presence presence NN cord-002728-6oyw5sqv 88 11 may may MD cord-002728-6oyw5sqv 88 12 have have VB cord-002728-6oyw5sqv 88 13 been be VBN cord-002728-6oyw5sqv 88 14 over over RB cord-002728-6oyw5sqv 88 15 - - HYPH cord-002728-6oyw5sqv 88 16 estimated estimate VBN cord-002728-6oyw5sqv 88 17 in in IN cord-002728-6oyw5sqv 88 18 human human JJ cord-002728-6oyw5sqv 88 19 viromes virome NNS cord-002728-6oyw5sqv 88 20 11 11 CD cord-002728-6oyw5sqv 88 21 , , , cord-002728-6oyw5sqv 88 22 20 20 CD cord-002728-6oyw5sqv 88 23 , , , cord-002728-6oyw5sqv 88 24 27 27 CD cord-002728-6oyw5sqv 88 25 , , , cord-002728-6oyw5sqv 88 26 31 31 CD cord-002728-6oyw5sqv 88 27 , , , cord-002728-6oyw5sqv 88 28 35 35 CD cord-002728-6oyw5sqv 88 29 , , , cord-002728-6oyw5sqv 88 30 37 37 CD cord-002728-6oyw5sqv 88 31 as as IN cord-002728-6oyw5sqv 88 32 these these DT cord-002728-6oyw5sqv 88 33 entities entity NNS cord-002728-6oyw5sqv 88 34 are be VBP cord-002728-6oyw5sqv 88 35 thought think VBN cord-002728-6oyw5sqv 88 36 to to TO cord-002728-6oyw5sqv 88 37 be be VB cord-002728-6oyw5sqv 88 38 rarely rarely RB cord-002728-6oyw5sqv 88 39 encoded encode VBN cord-002728-6oyw5sqv 88 40 in in IN cord-002728-6oyw5sqv 88 41 phages phage NNS cord-002728-6oyw5sqv 88 42 . . . cord-002728-6oyw5sqv 89 1 39 39 CD cord-002728-6oyw5sqv 89 2 Consequently consequently RB cord-002728-6oyw5sqv 89 3 , , , cord-002728-6oyw5sqv 89 4 care care NN cord-002728-6oyw5sqv 89 5 should should MD cord-002728-6oyw5sqv 89 6 be be VB cord-002728-6oyw5sqv 89 7 taken take VBN cord-002728-6oyw5sqv 89 8 when when WRB cord-002728-6oyw5sqv 89 9 analysing analyse VBG cord-002728-6oyw5sqv 89 10 data datum NNS cord-002728-6oyw5sqv 89 11 : : : cord-002728-6oyw5sqv 89 12 proper proper JJ cord-002728-6oyw5sqv 89 13 in in IN cord-002728-6oyw5sqv 89 14 silico silico NN cord-002728-6oyw5sqv 89 15 checks check NNS cord-002728-6oyw5sqv 89 16 with with IN cord-002728-6oyw5sqv 89 17 conservative conservative JJ cord-002728-6oyw5sqv 89 18 cut cut VBN cord-002728-6oyw5sqv 89 19 - - HYPH cord-002728-6oyw5sqv 89 20 offs off NNS cord-002728-6oyw5sqv 89 21 are be VBP cord-002728-6oyw5sqv 89 22 required require VBN cord-002728-6oyw5sqv 89 23 to to TO cord-002728-6oyw5sqv 89 24 refine refine VB cord-002728-6oyw5sqv 89 25 functional functional JJ cord-002728-6oyw5sqv 89 26 assignments assignment NNS cord-002728-6oyw5sqv 89 27 and and CC cord-002728-6oyw5sqv 89 28 avoid avoid VB cord-002728-6oyw5sqv 89 29 over over IN cord-002728-6oyw5sqv 89 30 - - HYPH cord-002728-6oyw5sqv 89 31 interpretation interpretation NN cord-002728-6oyw5sqv 89 32 of of IN cord-002728-6oyw5sqv 89 33 data datum NNS cord-002728-6oyw5sqv 89 34 . . . cord-002728-6oyw5sqv 90 1 39 39 CD cord-002728-6oyw5sqv 90 2 and and CC cord-002728-6oyw5sqv 90 3 geminiviruses geminiviruse NNS cord-002728-6oyw5sqv 90 4 were be VBD cord-002728-6oyw5sqv 90 5 detected detect VBN cord-002728-6oyw5sqv 90 6 in in IN cord-002728-6oyw5sqv 90 7 at at RB cord-002728-6oyw5sqv 90 8 least least RBS cord-002728-6oyw5sqv 90 9 one one CD cord-002728-6oyw5sqv 90 10 twin twin NN cord-002728-6oyw5sqv 90 11 of of IN cord-002728-6oyw5sqv 90 12 each each DT cord-002728-6oyw5sqv 90 13 pair pair NN cord-002728-6oyw5sqv 90 14 between between IN cord-002728-6oyw5sqv 90 15 months month NNS cord-002728-6oyw5sqv 90 16 3 3 CD cord-002728-6oyw5sqv 90 17 and and CC cord-002728-6oyw5sqv 90 18 24 24 CD cord-002728-6oyw5sqv 90 19 of of IN cord-002728-6oyw5sqv 90 20 the the DT cord-002728-6oyw5sqv 90 21 study study NN cord-002728-6oyw5sqv 90 22 . . . cord-002728-6oyw5sqv 91 1 46 46 CD cord-002728-6oyw5sqv 91 2 Anelloviruses Anelloviruses NNPS cord-002728-6oyw5sqv 91 3 , , , cord-002728-6oyw5sqv 91 4 associated associate VBN cord-002728-6oyw5sqv 91 5 with with IN cord-002728-6oyw5sqv 91 6 host host NN cord-002728-6oyw5sqv 91 7 immune immune JJ cord-002728-6oyw5sqv 91 8 status status NN cord-002728-6oyw5sqv 91 9 , , , cord-002728-6oyw5sqv 91 10 were be VBD cord-002728-6oyw5sqv 91 11 most most RBS cord-002728-6oyw5sqv 91 12 prevalent prevalent JJ cord-002728-6oyw5sqv 91 13 from from IN cord-002728-6oyw5sqv 91 14 3 3 CD cord-002728-6oyw5sqv 91 15 months month NNS cord-002728-6oyw5sqv 91 16 of of IN cord-002728-6oyw5sqv 91 17 age age NN cord-002728-6oyw5sqv 91 18 and and CC cord-002728-6oyw5sqv 91 19 highly highly RB cord-002728-6oyw5sqv 91 20 divergent divergent JJ cord-002728-6oyw5sqv 91 21 from from IN cord-002728-6oyw5sqv 91 22 known know VBN cord-002728-6oyw5sqv 91 23 anelloviruses anelloviruse NNS cord-002728-6oyw5sqv 91 24 , , , cord-002728-6oyw5sqv 91 25 with with IN cord-002728-6oyw5sqv 91 26 their -PRON- PRP$ cord-002728-6oyw5sqv 91 27 abundance abundance NN cord-002728-6oyw5sqv 91 28 peaking peak VBG cord-002728-6oyw5sqv 91 29 at at IN cord-002728-6oyw5sqv 91 30 6 6 CD cord-002728-6oyw5sqv 91 31 - - SYM cord-002728-6oyw5sqv 91 32 12 12 CD cord-002728-6oyw5sqv 91 33 months month NNS cord-002728-6oyw5sqv 91 34 of of IN cord-002728-6oyw5sqv 91 35 age age NN cord-002728-6oyw5sqv 91 36 . . . cord-002728-6oyw5sqv 92 1 The the DT cord-002728-6oyw5sqv 92 2 same same JJ cord-002728-6oyw5sqv 92 3 anelloviruses anelloviruse NNS cord-002728-6oyw5sqv 92 4 were be VBD cord-002728-6oyw5sqv 92 5 detected detect VBN cord-002728-6oyw5sqv 92 6 in in IN cord-002728-6oyw5sqv 92 7 faecal faecal JJ cord-002728-6oyw5sqv 92 8 samples sample NNS cord-002728-6oyw5sqv 92 9 of of IN cord-002728-6oyw5sqv 92 10 the the DT cord-002728-6oyw5sqv 92 11 same same JJ cord-002728-6oyw5sqv 92 12 infant infant NN cord-002728-6oyw5sqv 92 13 collected collect VBD cord-002728-6oyw5sqv 92 14 12 12 CD cord-002728-6oyw5sqv 92 15 months month NNS cord-002728-6oyw5sqv 92 16 apart apart RB cord-002728-6oyw5sqv 92 17 , , , cord-002728-6oyw5sqv 92 18 suggesting suggest VBG cord-002728-6oyw5sqv 92 19 a a DT cord-002728-6oyw5sqv 92 20 persistent persistent JJ cord-002728-6oyw5sqv 92 21 or or CC cord-002728-6oyw5sqv 92 22 stable stable JJ cord-002728-6oyw5sqv 92 23 source source NN cord-002728-6oyw5sqv 92 24 of of IN cord-002728-6oyw5sqv 92 25 recurring recur VBG cord-002728-6oyw5sqv 92 26 infection infection NN cord-002728-6oyw5sqv 92 27 . . . cord-002728-6oyw5sqv 93 1 46 46 CD cord-002728-6oyw5sqv 94 1 It -PRON- PRP cord-002728-6oyw5sqv 94 2 was be VBD cord-002728-6oyw5sqv 94 3 speculated speculate VBN cord-002728-6oyw5sqv 94 4 the the DT cord-002728-6oyw5sqv 94 5 increase increase NN cord-002728-6oyw5sqv 94 6 in in IN cord-002728-6oyw5sqv 94 7 anelloviruses anelloviruse NNS cord-002728-6oyw5sqv 94 8 between between IN cord-002728-6oyw5sqv 94 9 6 6 CD cord-002728-6oyw5sqv 94 10 46 46 CD cord-002728-6oyw5sqv 95 1 The the DT cord-002728-6oyw5sqv 95 2 initially initially RB cord-002728-6oyw5sqv 95 3 high high JJ cord-002728-6oyw5sqv 95 4 phage phage NN cord-002728-6oyw5sqv 95 5 population population NN cord-002728-6oyw5sqv 95 6 is be VBZ cord-002728-6oyw5sqv 95 7 unsustainable unsustainable JJ cord-002728-6oyw5sqv 95 8 because because IN cord-002728-6oyw5sqv 95 9 of of IN cord-002728-6oyw5sqv 95 10 low low JJ cord-002728-6oyw5sqv 95 11 numbers number NNS cord-002728-6oyw5sqv 95 12 of of IN cord-002728-6oyw5sqv 95 13 bacteria bacteria NNS cord-002728-6oyw5sqv 95 14 colonising colonise VBG cord-002728-6oyw5sqv 95 15 the the DT cord-002728-6oyw5sqv 95 16 GI GI NNP cord-002728-6oyw5sqv 95 17 tract tract NN cord-002728-6oyw5sqv 95 18 . . . cord-002728-6oyw5sqv 96 1 Consequently consequently RB cord-002728-6oyw5sqv 96 2 , , , cord-002728-6oyw5sqv 96 3 the the DT cord-002728-6oyw5sqv 96 4 phage phage NN cord-002728-6oyw5sqv 96 5 assemblage assemblage NN cord-002728-6oyw5sqv 96 6 shrinks shrink VBZ cord-002728-6oyw5sqv 96 7 in in IN cord-002728-6oyw5sqv 96 8 size size NN cord-002728-6oyw5sqv 96 9 and and CC cord-002728-6oyw5sqv 96 10 diversity diversity NN cord-002728-6oyw5sqv 96 11 , , , cord-002728-6oyw5sqv 96 12 relieving relieve VBG cord-002728-6oyw5sqv 96 13 pressure pressure NN cord-002728-6oyw5sqv 96 14 on on IN cord-002728-6oyw5sqv 96 15 the the DT cord-002728-6oyw5sqv 96 16 bacterial bacterial JJ cord-002728-6oyw5sqv 96 17 community community NN cord-002728-6oyw5sqv 96 18 and and CC cord-002728-6oyw5sqv 96 19 allowing allow VBG cord-002728-6oyw5sqv 96 20 it -PRON- PRP cord-002728-6oyw5sqv 96 21 to to TO cord-002728-6oyw5sqv 96 22 establish establish VB cord-002728-6oyw5sqv 96 23 and and CC cord-002728-6oyw5sqv 96 24 colonise colonise VB cord-002728-6oyw5sqv 96 25 the the DT cord-002728-6oyw5sqv 96 26 gut gut NN cord-002728-6oyw5sqv 96 27 . . . cord-002728-6oyw5sqv 97 1 Differences difference NNS cord-002728-6oyw5sqv 97 2 in in IN cord-002728-6oyw5sqv 97 3 birth birth NN cord-002728-6oyw5sqv 97 4 mode mode NN cord-002728-6oyw5sqv 98 1 ( ( -LRB- cord-002728-6oyw5sqv 98 2 Caesarean Caesarean NNP cord-002728-6oyw5sqv 98 3 vs vs IN cord-002728-6oyw5sqv 98 4 vaginal vaginal JJ cord-002728-6oyw5sqv 98 5 delivery delivery NN cord-002728-6oyw5sqv 98 6 ) ) -RRB- cord-002728-6oyw5sqv 98 7 and and CC cord-002728-6oyw5sqv 98 8 diet diet NN cord-002728-6oyw5sqv 98 9 ( ( -LRB- cord-002728-6oyw5sqv 98 10 breast breast NN cord-002728-6oyw5sqv 98 11 - - HYPH cord-002728-6oyw5sqv 98 12 vs vs RP cord-002728-6oyw5sqv 98 13 formula formula NN cord-002728-6oyw5sqv 98 14 - - HYPH cord-002728-6oyw5sqv 98 15 feeding feeding NN cord-002728-6oyw5sqv 98 16 ; ; : cord-002728-6oyw5sqv 98 17 age age NN cord-002728-6oyw5sqv 98 18 at at IN cord-002728-6oyw5sqv 98 19 which which WDT cord-002728-6oyw5sqv 98 20 weaning weaning NN cord-002728-6oyw5sqv 98 21 began begin VBD cord-002728-6oyw5sqv 98 22 ) ) -RRB- cord-002728-6oyw5sqv 98 23 were be VBD cord-002728-6oyw5sqv 98 24 confounders confounder NNS cord-002728-6oyw5sqv 98 25 in in IN cord-002728-6oyw5sqv 98 26 the the DT cord-002728-6oyw5sqv 98 27 study study NN cord-002728-6oyw5sqv 98 28 of of IN cord-002728-6oyw5sqv 98 29 Lim Lim NNP cord-002728-6oyw5sqv 98 30 et et NNP cord-002728-6oyw5sqv 98 31 al al NNP cord-002728-6oyw5sqv 98 32 . . . cord-002728-6oyw5sqv 99 1 46 46 CD cord-002728-6oyw5sqv 99 2 51 51 CD cord-002728-6oyw5sqv 99 3 , , , cord-002728-6oyw5sqv 99 4 54 54 CD cord-002728-6oyw5sqv 99 5 Circulating circulate VBG cord-002728-6oyw5sqv 99 6 phages phage NNS cord-002728-6oyw5sqv 99 7 have have VBP cord-002728-6oyw5sqv 99 8 also also RB cord-002728-6oyw5sqv 99 9 been be VBN cord-002728-6oyw5sqv 99 10 detected detect VBN cord-002728-6oyw5sqv 99 11 in in IN cord-002728-6oyw5sqv 99 12 blood blood NN cord-002728-6oyw5sqv 99 13 samples sample NNS cord-002728-6oyw5sqv 99 14 after after IN cord-002728-6oyw5sqv 99 15 oral oral JJ cord-002728-6oyw5sqv 99 16 administration administration NN cord-002728-6oyw5sqv 99 17 of of IN cord-002728-6oyw5sqv 99 18 antibiotics antibiotic NNS cord-002728-6oyw5sqv 99 19 to to IN cord-002728-6oyw5sqv 99 20 patients patient NNS cord-002728-6oyw5sqv 99 21 with with IN cord-002728-6oyw5sqv 99 22 bacterial bacterial JJ cord-002728-6oyw5sqv 99 23 infections infection NNS cord-002728-6oyw5sqv 99 24 , , , cord-002728-6oyw5sqv 99 25 whereas whereas IN cord-002728-6oyw5sqv 99 26 no no DT cord-002728-6oyw5sqv 99 27 phages phage NNS cord-002728-6oyw5sqv 99 28 could could MD cord-002728-6oyw5sqv 99 29 be be VB cord-002728-6oyw5sqv 99 30 detected detect VBN cord-002728-6oyw5sqv 99 31 in in IN cord-002728-6oyw5sqv 99 32 their -PRON- PRP$ cord-002728-6oyw5sqv 99 33 blood blood NN cord-002728-6oyw5sqv 99 34 prior prior RB cord-002728-6oyw5sqv 99 35 to to IN cord-002728-6oyw5sqv 99 36 antibiotic antibiotic JJ cord-002728-6oyw5sqv 99 37 therapy therapy NN cord-002728-6oyw5sqv 99 38 . . . cord-002728-6oyw5sqv 100 1 51 51 CD cord-002728-6oyw5sqv 101 1 It -PRON- PRP cord-002728-6oyw5sqv 101 2 is be VBZ cord-002728-6oyw5sqv 101 3 not not RB cord-002728-6oyw5sqv 101 4 known know VBN cord-002728-6oyw5sqv 101 5 if if IN cord-002728-6oyw5sqv 101 6 these these DT cord-002728-6oyw5sqv 101 7 phages phage NNS cord-002728-6oyw5sqv 101 8 were be VBD cord-002728-6oyw5sqv 101 9 of of IN cord-002728-6oyw5sqv 101 10 GI GI NNP cord-002728-6oyw5sqv 101 11 origin origin NN cord-002728-6oyw5sqv 101 12 . . . cord-002728-6oyw5sqv 102 1 The the DT cord-002728-6oyw5sqv 102 2 presence presence NN cord-002728-6oyw5sqv 102 3 of of IN cord-002728-6oyw5sqv 102 4 phages phage NNS cord-002728-6oyw5sqv 102 5 in in IN cord-002728-6oyw5sqv 102 6 the the DT cord-002728-6oyw5sqv 102 7 peripheral peripheral JJ cord-002728-6oyw5sqv 102 8 blood blood NN cord-002728-6oyw5sqv 102 9 has have VBZ cord-002728-6oyw5sqv 102 10 been be VBN cord-002728-6oyw5sqv 102 11 termed term VBN cord-002728-6oyw5sqv 102 12 " " `` cord-002728-6oyw5sqv 102 13 phagemia phagemia NN cord-002728-6oyw5sqv 102 14 " " '' cord-002728-6oyw5sqv 102 15 . . . cord-002728-6oyw5sqv 103 1 51 51 CD cord-002728-6oyw5sqv 104 1 However however RB cord-002728-6oyw5sqv 104 2 , , , cord-002728-6oyw5sqv 104 3 whether whether IN cord-002728-6oyw5sqv 104 4 the the DT cord-002728-6oyw5sqv 104 5 blood blood NN cord-002728-6oyw5sqv 104 6 contains contain VBZ cord-002728-6oyw5sqv 104 7 its -PRON- PRP$ cord-002728-6oyw5sqv 104 8 own own JJ cord-002728-6oyw5sqv 104 9 " " `` cord-002728-6oyw5sqv 104 10 baseline baseline JJ cord-002728-6oyw5sqv 104 11 " " '' cord-002728-6oyw5sqv 104 12 VLP VLP NNP cord-002728-6oyw5sqv 104 13 population population NN cord-002728-6oyw5sqv 104 14 to to TO cord-002728-6oyw5sqv 104 15 which which WDT cord-002728-6oyw5sqv 104 16 the the DT cord-002728-6oyw5sqv 104 17 GI GI NNP cord-002728-6oyw5sqv 104 18 virome virome NN cord-002728-6oyw5sqv 104 19 can can MD cord-002728-6oyw5sqv 104 20 contribute contribute VB cord-002728-6oyw5sqv 104 21 in in IN cord-002728-6oyw5sqv 104 22 disease disease NN cord-002728-6oyw5sqv 104 23 is be VBZ cord-002728-6oyw5sqv 104 24 unknown unknown JJ cord-002728-6oyw5sqv 104 25 . . . cord-002728-6oyw5sqv 105 1 in in IN cord-002728-6oyw5sqv 105 2 colonic colonic JJ cord-002728-6oyw5sqv 105 3 biopsies biopsy NNS cord-002728-6oyw5sqv 105 4 than than IN cord-002728-6oyw5sqv 105 5 healthy healthy JJ cord-002728-6oyw5sqv 105 6 individuals individual NNS cord-002728-6oyw5sqv 105 7 ( ( -LRB- cord-002728-6oyw5sqv 105 8 n n NN cord-002728-6oyw5sqv 105 9 = = SYM cord-002728-6oyw5sqv 105 10 10 10 CD cord-002728-6oyw5sqv 105 11 ) ) -RRB- cord-002728-6oyw5sqv 105 12 ( ( -LRB- cord-002728-6oyw5sqv 105 13 2.9 2.9 CD cord-002728-6oyw5sqv 105 14 9 9 CD cord-002728-6oyw5sqv 105 15 10 10 CD cord-002728-6oyw5sqv 105 16 9 9 CD cord-002728-6oyw5sqv 105 17 vs vs IN cord-002728-6oyw5sqv 105 18 1.2 1.2 CD cord-002728-6oyw5sqv 105 19 9 9 CD cord-002728-6oyw5sqv 105 20 10 10 CD cord-002728-6oyw5sqv 105 21 8 8 CD cord-002728-6oyw5sqv 105 22 VLPs vlp NNS cord-002728-6oyw5sqv 105 23 / / SYM cord-002728-6oyw5sqv 105 24 biopsy biopsy NN cord-002728-6oyw5sqv 105 25 ) ) -RRB- cord-002728-6oyw5sqv 105 26 , , , cord-002728-6oyw5sqv 105 27 and and CC cord-002728-6oyw5sqv 105 28 for for IN cord-002728-6oyw5sqv 105 29 the the DT cord-002728-6oyw5sqv 105 30 CD CD NNP cord-002728-6oyw5sqv 105 31 patients patient NNS cord-002728-6oyw5sqv 105 32 ulcerated ulcerated JJ cord-002728-6oyw5sqv 105 33 mucosa mucosa RB cord-002728-6oyw5sqv 105 34 had have VBD cord-002728-6oyw5sqv 105 35 significantly significantly RB cord-002728-6oyw5sqv 105 36 fewer few JJR cord-002728-6oyw5sqv 105 37 VLPs vlp NNS cord-002728-6oyw5sqv 105 38 than than IN cord-002728-6oyw5sqv 105 39 nonulcerated nonulcerated JJ cord-002728-6oyw5sqv 105 40 mucosa mucosa NN cord-002728-6oyw5sqv 105 41 ( ( -LRB- cord-002728-6oyw5sqv 105 42 2.1 2.1 CD cord-002728-6oyw5sqv 105 43 9 9 CD cord-002728-6oyw5sqv 105 44 10 10 CD cord-002728-6oyw5sqv 105 45 9 9 CD cord-002728-6oyw5sqv 105 46 vs vs IN cord-002728-6oyw5sqv 105 47 4.1 4.1 CD cord-002728-6oyw5sqv 105 48 9 9 CD cord-002728-6oyw5sqv 105 49 10 10 CD cord-002728-6oyw5sqv 105 50 9 9 CD cord-002728-6oyw5sqv 105 51 VLPs vlp NNS cord-002728-6oyw5sqv 105 52 / / SYM cord-002728-6oyw5sqv 105 53 biopsy biopsy NN cord-002728-6oyw5sqv 105 54 ) ) -RRB- cord-002728-6oyw5sqv 105 55 . . . cord-002728-6oyw5sqv 106 1 9 9 LS cord-002728-6oyw5sqv 106 2 More more RBR cord-002728-6oyw5sqv 106 3 recent recent JJ cord-002728-6oyw5sqv 106 4 , , , cord-002728-6oyw5sqv 106 5 small small JJ cord-002728-6oyw5sqv 106 6 - - HYPH cord-002728-6oyw5sqv 106 7 scale scale NN cord-002728-6oyw5sqv 106 8 studies study NNS cord-002728-6oyw5sqv 106 9 have have VBP cord-002728-6oyw5sqv 106 10 been be VBN cord-002728-6oyw5sqv 106 11 undertaken undertake VBN cord-002728-6oyw5sqv 106 12 to to TO cord-002728-6oyw5sqv 106 13 characterise characterise VB cord-002728-6oyw5sqv 106 14 the the DT cord-002728-6oyw5sqv 106 15 gut gut NN cord-002728-6oyw5sqv 106 16 virome virome NN cord-002728-6oyw5sqv 106 17 of of IN cord-002728-6oyw5sqv 106 18 IBD IBD NNP cord-002728-6oyw5sqv 106 19 . . . cord-002728-6oyw5sqv 107 1 29,62 29,62 CD cord-002728-6oyw5sqv 107 2 - - SYM cord-002728-6oyw5sqv 107 3 64 64 CD cord-002728-6oyw5sqv 108 1 A a DT cord-002728-6oyw5sqv 108 2 pilot pilot NN cord-002728-6oyw5sqv 108 3 metagenomic metagenomic JJ cord-002728-6oyw5sqv 108 4 study study NN cord-002728-6oyw5sqv 108 5 of of IN cord-002728-6oyw5sqv 108 6 ileal ileal JJ cord-002728-6oyw5sqv 108 7 and and CC cord-002728-6oyw5sqv 108 8 colonic colonic JJ cord-002728-6oyw5sqv 108 9 contents content NNS cord-002728-6oyw5sqv 108 10 of of IN cord-002728-6oyw5sqv 108 11 six six CD cord-002728-6oyw5sqv 108 12 CD cd NN cord-002728-6oyw5sqv 108 13 patients patient NNS cord-002728-6oyw5sqv 108 14 and and CC cord-002728-6oyw5sqv 108 15 ileal ileal JJ cord-002728-6oyw5sqv 108 16 samples sample NNS cord-002728-6oyw5sqv 108 17 from from IN cord-002728-6oyw5sqv 108 18 six six CD cord-002728-6oyw5sqv 108 19 non non JJ cord-002728-6oyw5sqv 108 20 - - JJ cord-002728-6oyw5sqv 108 21 IBD ibd JJ cord-002728-6oyw5sqv 108 22 controls control NNS cord-002728-6oyw5sqv 108 23 showed show VBD cord-002728-6oyw5sqv 108 24 CD CD NNP cord-002728-6oyw5sqv 108 25 DNA dna NN cord-002728-6oyw5sqv 108 26 - - HYPH cord-002728-6oyw5sqv 108 27 based base VBN cord-002728-6oyw5sqv 108 28 viromes virome NNS cord-002728-6oyw5sqv 108 29 had have VBD cord-002728-6oyw5sqv 108 30 higher high JJR cord-002728-6oyw5sqv 108 31 phage phage NN cord-002728-6oyw5sqv 108 32 abundance abundance NN cord-002728-6oyw5sqv 108 33 than than IN cord-002728-6oyw5sqv 108 34 control control NN cord-002728-6oyw5sqv 108 35 samples sample NNS cord-002728-6oyw5sqv 108 36 . . . cord-002728-6oyw5sqv 109 1 62 62 CD cord-002728-6oyw5sqv 110 1 However however RB cord-002728-6oyw5sqv 110 2 , , , cord-002728-6oyw5sqv 110 3 the the DT cord-002728-6oyw5sqv 110 4 ways way NNS cord-002728-6oyw5sqv 110 5 in in IN cord-002728-6oyw5sqv 110 6 which which WDT cord-002728-6oyw5sqv 110 7 virome virome NNP cord-002728-6oyw5sqv 110 8 data datum NNS cord-002728-6oyw5sqv 110 9 from from IN cord-002728-6oyw5sqv 110 10 healthy healthy JJ cord-002728-6oyw5sqv 110 11 controls control NNS cord-002728-6oyw5sqv 110 12 ( ( -LRB- cord-002728-6oyw5sqv 110 13 n n NN cord-002728-6oyw5sqv 110 14 = = SYM cord-002728-6oyw5sqv 110 15 8) 8) NN cord-002728-6oyw5sqv 110 16 and and CC cord-002728-6oyw5sqv 110 17 patients patient NNS cord-002728-6oyw5sqv 110 18 with with IN cord-002728-6oyw5sqv 110 19 ileocolic ileocolic JJ cord-002728-6oyw5sqv 110 20 CD CD NNP cord-002728-6oyw5sqv 110 21 ( ( -LRB- cord-002728-6oyw5sqv 110 22 n n NN cord-002728-6oyw5sqv 110 23 = = SYM cord-002728-6oyw5sqv 110 24 11 11 CD cord-002728-6oyw5sqv 110 25 ) ) -RRB- cord-002728-6oyw5sqv 110 26 were be VBD cord-002728-6oyw5sqv 110 27 analysed analyse VBN cord-002728-6oyw5sqv 110 28 were be VBD cord-002728-6oyw5sqv 110 29 found find VBN cord-002728-6oyw5sqv 110 30 to to TO cord-002728-6oyw5sqv 110 31 contribute contribute VB cord-002728-6oyw5sqv 110 32 to to IN cord-002728-6oyw5sqv 110 33 interpretation interpretation NN cord-002728-6oyw5sqv 110 34 of of IN cord-002728-6oyw5sqv 110 35 results result NNS cord-002728-6oyw5sqv 110 36 . . . cord-002728-6oyw5sqv 111 1 63 63 CD cord-002728-6oyw5sqv 111 2 Prophages Prophages NNP cord-002728-6oyw5sqv 111 3 represented represent VBD cord-002728-6oyw5sqv 111 4 the the DT cord-002728-6oyw5sqv 111 5 most most JJS cord-002728-6oyw5sqv 111 6 hits hit NNS cord-002728-6oyw5sqv 111 7 in in IN cord-002728-6oyw5sqv 111 8 the the DT cord-002728-6oyw5sqv 111 9 CD cd NN cord-002728-6oyw5sqv 111 10 samples sample NNS cord-002728-6oyw5sqv 111 11 when when WRB cord-002728-6oyw5sqv 111 12 unassembled unassembled JJ cord-002728-6oyw5sqv 111 13 reads read NNS cord-002728-6oyw5sqv 111 14 were be VBD cord-002728-6oyw5sqv 111 15 compared compare VBN cord-002728-6oyw5sqv 111 16 , , , cord-002728-6oyw5sqv 111 17 but but CC cord-002728-6oyw5sqv 111 18 were be VBD cord-002728-6oyw5sqv 111 19 higher high JJR cord-002728-6oyw5sqv 111 20 in in IN cord-002728-6oyw5sqv 111 21 the the DT cord-002728-6oyw5sqv 111 22 control control NN cord-002728-6oyw5sqv 111 23 group group NN cord-002728-6oyw5sqv 111 24 when when WRB cord-002728-6oyw5sqv 111 25 the the DT cord-002728-6oyw5sqv 111 26 assembled assemble VBN cord-002728-6oyw5sqv 111 27 data datum NNS cord-002728-6oyw5sqv 111 28 were be VBD cord-002728-6oyw5sqv 111 29 compared compare VBN cord-002728-6oyw5sqv 111 30 . . . cord-002728-6oyw5sqv 112 1 Analysis analysis NN cord-002728-6oyw5sqv 112 2 based base VBN cord-002728-6oyw5sqv 112 3 on on IN cord-002728-6oyw5sqv 112 4 assembled assemble VBN cord-002728-6oyw5sqv 112 5 data datum NNS cord-002728-6oyw5sqv 112 6 showed show VBD cord-002728-6oyw5sqv 112 7 fewer few JJR cord-002728-6oyw5sqv 112 8 differences difference NNS cord-002728-6oyw5sqv 112 9 between between IN cord-002728-6oyw5sqv 112 10 the the DT cord-002728-6oyw5sqv 112 11 CD CD NNP cord-002728-6oyw5sqv 112 12 and and CC cord-002728-6oyw5sqv 112 13 control control NN cord-002728-6oyw5sqv 112 14 group group NN cord-002728-6oyw5sqv 112 15 . . . cord-002728-6oyw5sqv 113 1 Nonrarefied nonrarefied JJ cord-002728-6oyw5sqv 113 2 data datum NNS cord-002728-6oyw5sqv 113 3 were be VBD cord-002728-6oyw5sqv 113 4 used use VBN cord-002728-6oyw5sqv 113 5 to to TO cord-002728-6oyw5sqv 113 6 generate generate VB cord-002728-6oyw5sqv 113 7 estimators estimator NNS cord-002728-6oyw5sqv 113 8 of of IN cord-002728-6oyw5sqv 113 9 species species NN cord-002728-6oyw5sqv 113 10 richness richness NN cord-002728-6oyw5sqv 113 11 : : : cord-002728-6oyw5sqv 113 12 the the DT cord-002728-6oyw5sqv 113 13 viromes virome NNS cord-002728-6oyw5sqv 113 14 of of IN cord-002728-6oyw5sqv 113 15 CD cd NN cord-002728-6oyw5sqv 113 16 patients patient NNS cord-002728-6oyw5sqv 113 17 were be VBD cord-002728-6oyw5sqv 113 18 less less RBR cord-002728-6oyw5sqv 113 19 diverse diverse JJ cord-002728-6oyw5sqv 113 20 than than IN cord-002728-6oyw5sqv 113 21 the the DT cord-002728-6oyw5sqv 113 22 healthy healthy JJ cord-002728-6oyw5sqv 113 23 patients patient NNS cord-002728-6oyw5sqv 113 24 , , , cord-002728-6oyw5sqv 113 25 but but CC cord-002728-6oyw5sqv 113 26 showed show VBD cord-002728-6oyw5sqv 113 27 greater great JJR cord-002728-6oyw5sqv 113 28 heterogeneity heterogeneity NN cord-002728-6oyw5sqv 113 29 across across IN cord-002728-6oyw5sqv 113 30 samples sample NNS cord-002728-6oyw5sqv 113 31 . . . cord-002728-6oyw5sqv 114 1 The the DT cord-002728-6oyw5sqv 114 2 CD cd NN cord-002728-6oyw5sqv 114 3 and and CC cord-002728-6oyw5sqv 114 4 control control NN cord-002728-6oyw5sqv 114 5 samples sample NNS cord-002728-6oyw5sqv 114 6 could could MD cord-002728-6oyw5sqv 114 7 not not RB cord-002728-6oyw5sqv 114 8 be be VB cord-002728-6oyw5sqv 114 9 fully fully RB cord-002728-6oyw5sqv 114 10 separated separate VBN cord-002728-6oyw5sqv 114 11 into into IN cord-002728-6oyw5sqv 114 12 two two CD cord-002728-6oyw5sqv 114 13 groups group NNS cord-002728-6oyw5sqv 114 14 based base VBN cord-002728-6oyw5sqv 114 15 on on IN cord-002728-6oyw5sqv 114 16 VLP VLP NNP cord-002728-6oyw5sqv 114 17 composition composition NN cord-002728-6oyw5sqv 114 18 and and CC cord-002728-6oyw5sqv 114 19 abundance abundance NN cord-002728-6oyw5sqv 114 20 . . . cord-002728-6oyw5sqv 115 1 A a DT cord-002728-6oyw5sqv 115 2 later later JJ cord-002728-6oyw5sqv 115 3 DNA dna NN cord-002728-6oyw5sqv 115 4 - - HYPH cord-002728-6oyw5sqv 115 5 based base VBN cord-002728-6oyw5sqv 115 6 study study NN cord-002728-6oyw5sqv 115 7 showed show VBD cord-002728-6oyw5sqv 115 8 differences difference NNS cord-002728-6oyw5sqv 115 9 in in IN cord-002728-6oyw5sqv 115 10 CD cd NN cord-002728-6oyw5sqv 115 11 patients patient NNS cord-002728-6oyw5sqv 115 12 related relate VBN cord-002728-6oyw5sqv 115 13 to to IN cord-002728-6oyw5sqv 115 14 disease disease NN cord-002728-6oyw5sqv 115 15 status status NN cord-002728-6oyw5sqv 115 16 ( ( -LRB- cord-002728-6oyw5sqv 115 17 newly newly RB cord-002728-6oyw5sqv 115 18 diagnosed diagnose VBN cord-002728-6oyw5sqv 115 19 , , , cord-002728-6oyw5sqv 115 20 active active JJ cord-002728-6oyw5sqv 115 21 onset onset NN cord-002728-6oyw5sqv 115 22 , , , cord-002728-6oyw5sqv 115 23 active active JJ cord-002728-6oyw5sqv 115 24 presurgery presurgery NN cord-002728-6oyw5sqv 115 25 ) ) -RRB- cord-002728-6oyw5sqv 115 26 and and CC cord-002728-6oyw5sqv 115 27 therapy therapy NN cord-002728-6oyw5sqv 115 28 . . . cord-002728-6oyw5sqv 116 1 65 65 CD cord-002728-6oyw5sqv 117 1 Similar similar JJ cord-002728-6oyw5sqv 117 2 to to IN cord-002728-6oyw5sqv 117 3 their -PRON- PRP$ cord-002728-6oyw5sqv 117 4 previous previous JJ cord-002728-6oyw5sqv 117 5 study study NN cord-002728-6oyw5sqv 117 6 , , , cord-002728-6oyw5sqv 117 7 individual individual JJ cord-002728-6oyw5sqv 117 8 variability variability NN cord-002728-6oyw5sqv 117 9 and and CC cord-002728-6oyw5sqv 117 10 sample sample NN cord-002728-6oyw5sqv 117 11 origin origin NN cord-002728-6oyw5sqv 117 12 had have VBD cord-002728-6oyw5sqv 117 13 a a DT cord-002728-6oyw5sqv 117 14 greater great JJR cord-002728-6oyw5sqv 117 15 effect effect NN cord-002728-6oyw5sqv 117 16 on on IN cord-002728-6oyw5sqv 117 17 the the DT cord-002728-6oyw5sqv 117 18 virome virome NN cord-002728-6oyw5sqv 117 19 than than IN cord-002728-6oyw5sqv 117 20 CD CD NNP cord-002728-6oyw5sqv 117 21 , , , cord-002728-6oyw5sqv 117 22 although although IN cord-002728-6oyw5sqv 117 23 more more JJR cord-002728-6oyw5sqv 117 24 over over RB cord-002728-6oyw5sqv 117 25 - - HYPH cord-002728-6oyw5sqv 117 26 represented represent VBN cord-002728-6oyw5sqv 117 27 viruses virus NNS cord-002728-6oyw5sqv 117 28 were be VBD cord-002728-6oyw5sqv 117 29 found find VBN cord-002728-6oyw5sqv 117 30 in in IN cord-002728-6oyw5sqv 117 31 the the DT cord-002728-6oyw5sqv 117 32 CD CD NNP cord-002728-6oyw5sqv 117 33 viromes virome NNS cord-002728-6oyw5sqv 117 34 than than IN cord-002728-6oyw5sqv 117 35 the the DT cord-002728-6oyw5sqv 117 36 healthy healthy JJ cord-002728-6oyw5sqv 117 37 , , , cord-002728-6oyw5sqv 117 38 and and CC cord-002728-6oyw5sqv 117 39 newly newly RB cord-002728-6oyw5sqv 117 40 diagnosed diagnose VBN cord-002728-6oyw5sqv 117 41 patients patient NNS cord-002728-6oyw5sqv 117 42 had have VBD cord-002728-6oyw5sqv 117 43 higher high JJR cord-002728-6oyw5sqv 117 44 diversity diversity NN cord-002728-6oyw5sqv 117 45 in in IN cord-002728-6oyw5sqv 117 46 faecal faecal JJ cord-002728-6oyw5sqv 117 47 and and CC cord-002728-6oyw5sqv 117 48 biopsy biopsy JJ cord-002728-6oyw5sqv 117 49 viromes virome NNS cord-002728-6oyw5sqv 117 50 than than IN cord-002728-6oyw5sqv 117 51 those those DT cord-002728-6oyw5sqv 117 52 with with IN cord-002728-6oyw5sqv 117 53 active active JJ cord-002728-6oyw5sqv 117 54 disease disease NN cord-002728-6oyw5sqv 117 55 . . . cord-002728-6oyw5sqv 118 1 Patients patient NNS cord-002728-6oyw5sqv 118 2 on on IN cord-002728-6oyw5sqv 118 3 steroids steroid NNS cord-002728-6oyw5sqv 118 4 and/or and/or CC cord-002728-6oyw5sqv 118 5 immunosuppressors immunosuppressor NNS cord-002728-6oyw5sqv 118 6 had have VBD cord-002728-6oyw5sqv 118 7 lower low JJR cord-002728-6oyw5sqv 118 8 diversity diversity NN cord-002728-6oyw5sqv 118 9 than than IN cord-002728-6oyw5sqv 118 10 untreated untreated JJ cord-002728-6oyw5sqv 118 11 patients patient NNS cord-002728-6oyw5sqv 118 12 , , , cord-002728-6oyw5sqv 118 13 while while IN cord-002728-6oyw5sqv 118 14 those those DT cord-002728-6oyw5sqv 118 15 on on IN cord-002728-6oyw5sqv 118 16 immunosuppressors immunosuppressor NNS cord-002728-6oyw5sqv 118 17 only only RB cord-002728-6oyw5sqv 118 18 had have VBD cord-002728-6oyw5sqv 118 19 lower low JJR cord-002728-6oyw5sqv 118 20 diversity diversity NN cord-002728-6oyw5sqv 118 21 than than IN cord-002728-6oyw5sqv 118 22 those those DT cord-002728-6oyw5sqv 118 23 on on IN cord-002728-6oyw5sqv 118 24 combination combination NN cord-002728-6oyw5sqv 118 25 therapy therapy NN cord-002728-6oyw5sqv 118 26 or or CC cord-002728-6oyw5sqv 118 27 steroids steroid NNS cord-002728-6oyw5sqv 118 28 only only RB cord-002728-6oyw5sqv 118 29 . . . cord-002728-6oyw5sqv 119 1 The the DT cord-002728-6oyw5sqv 119 2 study study NN cord-002728-6oyw5sqv 119 3 benefitted benefit VBD cord-002728-6oyw5sqv 119 4 from from IN cord-002728-6oyw5sqv 119 5 recruiting recruit VBG cord-002728-6oyw5sqv 119 6 CD cd NN cord-002728-6oyw5sqv 119 7 and and CC cord-002728-6oyw5sqv 119 8 ulcerative ulcerative JJ cord-002728-6oyw5sqv 119 9 colitis colitis NN cord-002728-6oyw5sqv 119 10 ( ( -LRB- cord-002728-6oyw5sqv 119 11 UC UC NNP cord-002728-6oyw5sqv 119 12 ) ) -RRB- cord-002728-6oyw5sqv 119 13 patients patient NNS cord-002728-6oyw5sqv 119 14 and and CC cord-002728-6oyw5sqv 119 15 their -PRON- PRP$ cord-002728-6oyw5sqv 119 16 family family NN cord-002728-6oyw5sqv 119 17 members member NNS cord-002728-6oyw5sqv 119 18 in in IN cord-002728-6oyw5sqv 119 19 the the DT cord-002728-6oyw5sqv 119 20 UK UK NNP cord-002728-6oyw5sqv 119 21 ( ( -LRB- cord-002728-6oyw5sqv 119 22 Cambridge Cambridge NNP cord-002728-6oyw5sqv 119 23 ) ) -RRB- cord-002728-6oyw5sqv 119 24 and and CC cord-002728-6oyw5sqv 119 25 USA USA NNP cord-002728-6oyw5sqv 119 26 ( ( -LRB- cord-002728-6oyw5sqv 119 27 Los Los NNP cord-002728-6oyw5sqv 119 28 Angeles Angeles NNP cord-002728-6oyw5sqv 119 29 ) ) -RRB- cord-002728-6oyw5sqv 119 30 , , , cord-002728-6oyw5sqv 119 31 thereby thereby RB cord-002728-6oyw5sqv 119 32 controlling control VBG cord-002728-6oyw5sqv 119 33 for for IN cord-002728-6oyw5sqv 119 34 household household NN cord-002728-6oyw5sqv 119 35 factors factor NNS cord-002728-6oyw5sqv 119 36 that that WDT cord-002728-6oyw5sqv 119 37 may may MD cord-002728-6oyw5sqv 119 38 influence influence VB cord-002728-6oyw5sqv 119 39 the the DT cord-002728-6oyw5sqv 119 40 microbiome microbiome NN cord-002728-6oyw5sqv 119 41 . . . cord-002728-6oyw5sqv 120 1 29 29 CD cord-002728-6oyw5sqv 121 1 An an DT cord-002728-6oyw5sqv 121 2 increase increase NN cord-002728-6oyw5sqv 121 3 in in IN cord-002728-6oyw5sqv 121 4 phage phage NN cord-002728-6oyw5sqv 121 5 - - HYPH cord-002728-6oyw5sqv 121 6 associated associate VBN cord-002728-6oyw5sqv 121 7 richness richness NN cord-002728-6oyw5sqv 121 8 ( ( -LRB- cord-002728-6oyw5sqv 121 9 predominantly predominantly RB cord-002728-6oyw5sqv 121 10 Caudovirales Caudovirales NNP cord-002728-6oyw5sqv 121 11 and and CC cord-002728-6oyw5sqv 121 12 Microviridae Microviridae NNP cord-002728-6oyw5sqv 121 13 ) ) -RRB- cord-002728-6oyw5sqv 121 14 was be VBD cord-002728-6oyw5sqv 121 15 seen see VBN cord-002728-6oyw5sqv 121 16 in in IN cord-002728-6oyw5sqv 121 17 IBD IBD NNP cord-002728-6oyw5sqv 121 18 faecal faecal JJ cord-002728-6oyw5sqv 121 19 viromes virome NNS cord-002728-6oyw5sqv 121 20 compared compare VBN cord-002728-6oyw5sqv 121 21 with with IN cord-002728-6oyw5sqv 121 22 those those DT cord-002728-6oyw5sqv 121 23 of of IN cord-002728-6oyw5sqv 121 24 controls control NNS cord-002728-6oyw5sqv 121 25 . . . cord-002728-6oyw5sqv 122 1 Initial initial JJ cord-002728-6oyw5sqv 122 2 findings finding NNS cord-002728-6oyw5sqv 122 3 were be VBD cord-002728-6oyw5sqv 122 4 confirmed confirm VBN cord-002728-6oyw5sqv 122 5 using use VBG cord-002728-6oyw5sqv 122 6 two two CD cord-002728-6oyw5sqv 122 7 independent independent JJ cord-002728-6oyw5sqv 122 8 and and CC cord-002728-6oyw5sqv 122 9 geographically geographically RB cord-002728-6oyw5sqv 122 10 distinct distinct JJ cord-002728-6oyw5sqv 122 11 US US NNP cord-002728-6oyw5sqv 122 12 ( ( -LRB- cord-002728-6oyw5sqv 122 13 Boston Boston NNP cord-002728-6oyw5sqv 122 14 , , , cord-002728-6oyw5sqv 122 15 Chicago Chicago NNP cord-002728-6oyw5sqv 122 16 ) ) -RRB- cord-002728-6oyw5sqv 122 17 patient patient JJ cord-002728-6oyw5sqv 122 18 cohorts cohort NNS cord-002728-6oyw5sqv 122 19 with with IN cord-002728-6oyw5sqv 122 20 matched matched JJ cord-002728-6oyw5sqv 122 21 controls control NNS cord-002728-6oyw5sqv 122 22 . . . cord-002728-6oyw5sqv 123 1 29 29 CD cord-002728-6oyw5sqv 124 1 It -PRON- PRP cord-002728-6oyw5sqv 124 2 was be VBD cord-002728-6oyw5sqv 124 3 suggested suggest VBN cord-002728-6oyw5sqv 124 4 decreases decrease NNS cord-002728-6oyw5sqv 124 5 in in IN cord-002728-6oyw5sqv 124 6 bacterial bacterial JJ cord-002728-6oyw5sqv 124 7 richness richness NN cord-002728-6oyw5sqv 124 8 concomitant concomitant JJ cord-002728-6oyw5sqv 124 9 with with IN cord-002728-6oyw5sqv 124 10 increases increase NNS cord-002728-6oyw5sqv 124 11 in in IN cord-002728-6oyw5sqv 124 12 phage phage NN cord-002728-6oyw5sqv 124 13 richness richness NN cord-002728-6oyw5sqv 124 14 may may MD cord-002728-6oyw5sqv 124 15 be be VB cord-002728-6oyw5sqv 124 16 due due JJ cord-002728-6oyw5sqv 124 17 to to IN cord-002728-6oyw5sqv 124 18 predator predator NN cord-002728-6oyw5sqv 124 19 - - HYPH cord-002728-6oyw5sqv 124 20 prey prey NN cord-002728-6oyw5sqv 124 21 dynamics dynamic NNS cord-002728-6oyw5sqv 124 22 , , , cord-002728-6oyw5sqv 124 23 but but CC cord-002728-6oyw5sqv 124 24 it -PRON- PRP cord-002728-6oyw5sqv 124 25 was be VBD cord-002728-6oyw5sqv 124 26 unclear unclear JJ cord-002728-6oyw5sqv 124 27 how how WRB cord-002728-6oyw5sqv 124 28 these these DT cord-002728-6oyw5sqv 124 29 contribute contribute VBP cord-002728-6oyw5sqv 124 30 to to IN cord-002728-6oyw5sqv 124 31 the the DT cord-002728-6oyw5sqv 124 32 pathogenesis pathogenesis NN cord-002728-6oyw5sqv 124 33 of of IN cord-002728-6oyw5sqv 124 34 IBD IBD NNP cord-002728-6oyw5sqv 124 35 . . . cord-002728-6oyw5sqv 125 1 Also also RB cord-002728-6oyw5sqv 125 2 proposed propose VBN cord-002728-6oyw5sqv 125 3 was be VBD cord-002728-6oyw5sqv 125 4 the the DT cord-002728-6oyw5sqv 125 5 virome virome NN cord-002728-6oyw5sqv 125 6 as as IN cord-002728-6oyw5sqv 125 7 a a DT cord-002728-6oyw5sqv 125 8 target target NN cord-002728-6oyw5sqv 125 9 for for IN cord-002728-6oyw5sqv 125 10 therapeutic therapeutic JJ cord-002728-6oyw5sqv 125 11 modulation modulation NN cord-002728-6oyw5sqv 125 12 . . . cord-002728-6oyw5sqv 126 1 29 29 CD cord-002728-6oyw5sqv 126 2 _SP cord-002728-6oyw5sqv 127 1 Few few JJ cord-002728-6oyw5sqv 127 2 studies study NNS cord-002728-6oyw5sqv 127 3 of of IN cord-002728-6oyw5sqv 127 4 the the DT cord-002728-6oyw5sqv 127 5 human human JJ cord-002728-6oyw5sqv 127 6 virome virome NNP cord-002728-6oyw5sqv 127 7 have have VBP cord-002728-6oyw5sqv 127 8 considered consider VBN cord-002728-6oyw5sqv 127 9 the the DT cord-002728-6oyw5sqv 127 10 effects effect NNS cord-002728-6oyw5sqv 127 11 of of IN cord-002728-6oyw5sqv 127 12 contaminants contaminant NNS cord-002728-6oyw5sqv 127 13 in in IN cord-002728-6oyw5sqv 127 14 reagents reagent NNS cord-002728-6oyw5sqv 127 15 and and CC cord-002728-6oyw5sqv 127 16 nucleic nucleic JJ cord-002728-6oyw5sqv 127 17 acid acid NN cord-002728-6oyw5sqv 127 18 extraction extraction NN cord-002728-6oyw5sqv 127 19 kits kit NNS cord-002728-6oyw5sqv 127 20 on on IN cord-002728-6oyw5sqv 127 21 viral viral JJ cord-002728-6oyw5sqv 127 22 metagenomes metagenome NNS cord-002728-6oyw5sqv 127 23 ( ( -LRB- cord-002728-6oyw5sqv 127 24 Table Table NNP cord-002728-6oyw5sqv 127 25 S1 S1 NNP cord-002728-6oyw5sqv 127 26 ) ) -RRB- cord-002728-6oyw5sqv 127 27 , , , cord-002728-6oyw5sqv 127 28 though though IN cord-002728-6oyw5sqv 127 29 these these DT cord-002728-6oyw5sqv 127 30 are be VBP cord-002728-6oyw5sqv 127 31 being be VBG cord-002728-6oyw5sqv 127 32 increasingly increasingly RB cord-002728-6oyw5sqv 127 33 recognised recognise VBN cord-002728-6oyw5sqv 127 34 in in IN cord-002728-6oyw5sqv 127 35 prokaryote prokaryote NN cord-002728-6oyw5sqv 127 36 - - HYPH cord-002728-6oyw5sqv 127 37 focused focus VBN cord-002728-6oyw5sqv 127 38 studies study NNS cord-002728-6oyw5sqv 127 39 . . . cord-002728-6oyw5sqv 128 1 26 26 CD cord-002728-6oyw5sqv 128 2 , , , cord-002728-6oyw5sqv 128 3 69 69 CD cord-002728-6oyw5sqv 128 4 , , , cord-002728-6oyw5sqv 128 5 70 70 CD cord-002728-6oyw5sqv 128 6 Nucleases nuclease NNS cord-002728-6oyw5sqv 128 7 , , , cord-002728-6oyw5sqv 128 8 proteases protease NNS cord-002728-6oyw5sqv 128 9 and and CC cord-002728-6oyw5sqv 128 10 polymerases polymerase NNS cord-002728-6oyw5sqv 128 11 used use VBN cord-002728-6oyw5sqv 128 12 in in IN cord-002728-6oyw5sqv 128 13 studies study NNS cord-002728-6oyw5sqv 128 14 are be VBP cord-002728-6oyw5sqv 128 15 produced produce VBN cord-002728-6oyw5sqv 128 16 in in IN cord-002728-6oyw5sqv 128 17 protein protein NN cord-002728-6oyw5sqv 128 18 expression expression NN cord-002728-6oyw5sqv 128 19 systems system NNS cord-002728-6oyw5sqv 128 20 , , , cord-002728-6oyw5sqv 128 21 and and CC cord-002728-6oyw5sqv 128 22 sequences sequence NNS cord-002728-6oyw5sqv 128 23 associated associate VBN cord-002728-6oyw5sqv 128 24 with with IN cord-002728-6oyw5sqv 128 25 these these DT cord-002728-6oyw5sqv 128 26 expression expression NN cord-002728-6oyw5sqv 128 27 vectors vector NNS cord-002728-6oyw5sqv 128 28 have have VBP cord-002728-6oyw5sqv 128 29 been be VBN cord-002728-6oyw5sqv 128 30 detected detect VBN cord-002728-6oyw5sqv 128 31 in in IN cord-002728-6oyw5sqv 128 32 virome virome NNP cord-002728-6oyw5sqv 128 33 studies study NNS cord-002728-6oyw5sqv 128 34 . . . cord-002728-6oyw5sqv 129 1 70 70 CD cord-002728-6oyw5sqv 129 2 Columns column NNS cord-002728-6oyw5sqv 129 3 used use VBD cord-002728-6oyw5sqv 129 4 to to TO cord-002728-6oyw5sqv 129 5 purify purify VB cord-002728-6oyw5sqv 129 6 DNA DNA NNP cord-002728-6oyw5sqv 129 7 may may MD cord-002728-6oyw5sqv 129 8 introduce introduce VB cord-002728-6oyw5sqv 129 9 parvovirus parvovirus NN cord-002728-6oyw5sqv 129 10 - - HYPH cord-002728-6oyw5sqv 129 11 like like JJ cord-002728-6oyw5sqv 129 12 , , , cord-002728-6oyw5sqv 129 13 circoviruses circoviruses NNP cord-002728-6oyw5sqv 129 14 / / SYM cord-002728-6oyw5sqv 129 15 densoviruses densoviruses NNP cord-002728-6oyw5sqv 129 16 and and CC cord-002728-6oyw5sqv 129 17 iridoviruses iridoviruses NNP cord-002728-6oyw5sqv 129 18 sequences sequence NNS cord-002728-6oyw5sqv 129 19 into into IN cord-002728-6oyw5sqv 129 20 samples sample NNS cord-002728-6oyw5sqv 129 21 , , , cord-002728-6oyw5sqv 129 22 and and CC cord-002728-6oyw5sqv 129 23 it -PRON- PRP cord-002728-6oyw5sqv 129 24 has have VBZ cord-002728-6oyw5sqv 129 25 been be VBN cord-002728-6oyw5sqv 129 26 suggested suggest VBN cord-002728-6oyw5sqv 129 27 their -PRON- PRP$ cord-002728-6oyw5sqv 129 28 use use NN cord-002728-6oyw5sqv 129 29 should should MD cord-002728-6oyw5sqv 129 30 be be VB cord-002728-6oyw5sqv 129 31 avoided avoid VBN cord-002728-6oyw5sqv 129 32 in in IN cord-002728-6oyw5sqv 129 33 virome virome NNP cord-002728-6oyw5sqv 129 34 studies study NNS cord-002728-6oyw5sqv 129 35 . . . cord-002728-6oyw5sqv 130 1 26 26 CD cord-002728-6oyw5sqv 130 2 , , , cord-002728-6oyw5sqv 130 3 70 70 CD cord-002728-6oyw5sqv 130 4 Efforts effort NNS cord-002728-6oyw5sqv 130 5 should should MD cord-002728-6oyw5sqv 130 6 be be VB cord-002728-6oyw5sqv 130 7 made make VBN cord-002728-6oyw5sqv 130 8 to to TO cord-002728-6oyw5sqv 130 9 prevent prevent VB cord-002728-6oyw5sqv 130 10 cross cross NN cord-002728-6oyw5sqv 130 11 - - NN cord-002728-6oyw5sqv 130 12 contamination contamination NN cord-002728-6oyw5sqv 130 13 of of IN cord-002728-6oyw5sqv 130 14 samples sample NNS cord-002728-6oyw5sqv 130 15 when when WRB cord-002728-6oyw5sqv 130 16 processing processing NN cord-002728-6oyw5sqv 130 17 samples sample NNS cord-002728-6oyw5sqv 130 18 for for IN cord-002728-6oyw5sqv 130 19 nucleic nucleic JJ cord-002728-6oyw5sqv 130 20 acid acid NN cord-002728-6oyw5sqv 130 21 extraction extraction NN cord-002728-6oyw5sqv 130 22 and and CC cord-002728-6oyw5sqv 130 23 sequencing sequencing NN cord-002728-6oyw5sqv 130 24 . . . cord-002728-6oyw5sqv 131 1 26 26 CD cord-002728-6oyw5sqv 131 2 , , , cord-002728-6oyw5sqv 131 3 70 70 CD cord-002728-6oyw5sqv 131 4 Low low JJ cord-002728-6oyw5sqv 131 5 - - HYPH cord-002728-6oyw5sqv 131 6 biomass biomass NN cord-002728-6oyw5sqv 131 7 samples sample NNS cord-002728-6oyw5sqv 131 8 obtained obtain VBN cord-002728-6oyw5sqv 131 9 from from IN cord-002728-6oyw5sqv 131 10 non non JJ cord-002728-6oyw5sqv 131 11 - - JJ cord-002728-6oyw5sqv 131 12 GI gi JJ cord-002728-6oyw5sqv 131 13 sites site NNS cord-002728-6oyw5sqv 131 14 will will MD cord-002728-6oyw5sqv 131 15 be be VB cord-002728-6oyw5sqv 131 16 reliant reliant JJ cord-002728-6oyw5sqv 131 17 on on IN cord-002728-6oyw5sqv 131 18 PCR PCR NNP cord-002728-6oyw5sqv 131 19 - - HYPH cord-002728-6oyw5sqv 131 20 based base VBN cord-002728-6oyw5sqv 131 21 approaches approach NNS cord-002728-6oyw5sqv 131 22 for for IN cord-002728-6oyw5sqv 131 23 the the DT cord-002728-6oyw5sqv 131 24 foreseeable foreseeable JJ cord-002728-6oyw5sqv 131 25 future future NN cord-002728-6oyw5sqv 131 26 , , , cord-002728-6oyw5sqv 131 27 and and CC cord-002728-6oyw5sqv 131 28 these these DT cord-002728-6oyw5sqv 131 29 are be VBP cord-002728-6oyw5sqv 131 30 most most RBS cord-002728-6oyw5sqv 131 31 likely likely JJ cord-002728-6oyw5sqv 131 32 to to TO cord-002728-6oyw5sqv 131 33 be be VB cord-002728-6oyw5sqv 131 34 affected affect VBN cord-002728-6oyw5sqv 131 35 by by IN cord-002728-6oyw5sqv 131 36 contaminants contaminant NNS cord-002728-6oyw5sqv 131 37 in in IN cord-002728-6oyw5sqv 131 38 reagents reagent NNS cord-002728-6oyw5sqv 131 39 . . . cord-002728-6oyw5sqv 132 1 Therefore therefore RB cord-002728-6oyw5sqv 132 2 , , , cord-002728-6oyw5sqv 132 3 appropriate appropriate JJ cord-002728-6oyw5sqv 132 4 negative negative JJ cord-002728-6oyw5sqv 132 5 controls control NNS cord-002728-6oyw5sqv 132 6 should should MD cord-002728-6oyw5sqv 132 7 be be VB cord-002728-6oyw5sqv 132 8 included include VBN cord-002728-6oyw5sqv 132 9 in in IN cord-002728-6oyw5sqv 132 10 sequencing sequencing NN cord-002728-6oyw5sqv 132 11 studies study NNS cord-002728-6oyw5sqv 132 12 , , , cord-002728-6oyw5sqv 132 13 to to TO cord-002728-6oyw5sqv 132 14 allow allow VB cord-002728-6oyw5sqv 132 15 the the DT cord-002728-6oyw5sqv 132 16 identification identification NN cord-002728-6oyw5sqv 132 17 of of IN cord-002728-6oyw5sqv 132 18 sample sample NN cord-002728-6oyw5sqv 132 19 - - HYPH cord-002728-6oyw5sqv 132 20 associated associate VBN cord-002728-6oyw5sqv 132 21 sequences sequence NNS cord-002728-6oyw5sqv 132 22 rather rather RB cord-002728-6oyw5sqv 132 23 than than IN cord-002728-6oyw5sqv 132 24 those those DT cord-002728-6oyw5sqv 132 25 from from IN cord-002728-6oyw5sqv 132 26 contaminants contaminant NNS cord-002728-6oyw5sqv 132 27 . . . cord-002728-6oyw5sqv 133 1 Those those DT cord-002728-6oyw5sqv 133 2 studies study NNS cord-002728-6oyw5sqv 133 3 targeting target VBG cord-002728-6oyw5sqv 133 4 only only RB cord-002728-6oyw5sqv 133 5 the the DT cord-002728-6oyw5sqv 133 6 VLPs vlp NNS cord-002728-6oyw5sqv 133 7 of of IN cord-002728-6oyw5sqv 133 8 the the DT cord-002728-6oyw5sqv 133 9 microbiota microbiota NN cord-002728-6oyw5sqv 133 10 will will MD cord-002728-6oyw5sqv 133 11 not not RB cord-002728-6oyw5sqv 133 12 capture capture VB cord-002728-6oyw5sqv 133 13 prophage prophage NN cord-002728-6oyw5sqv 133 14 diversity diversity NN cord-002728-6oyw5sqv 133 15 within within IN cord-002728-6oyw5sqv 133 16 samples sample NNS cord-002728-6oyw5sqv 133 17 , , , cord-002728-6oyw5sqv 133 18 and and CC cord-002728-6oyw5sqv 133 19 will will MD cord-002728-6oyw5sqv 133 20 contain contain VB cord-002728-6oyw5sqv 133 21 little little JJ cord-002728-6oyw5sqv 133 22 information information NN cord-002728-6oyw5sqv 133 23 to to TO cord-002728-6oyw5sqv 133 24 allow allow VB cord-002728-6oyw5sqv 133 25 studies study NNS cord-002728-6oyw5sqv 133 26 of of IN cord-002728-6oyw5sqv 133 27 phage phage NN cord-002728-6oyw5sqv 133 28 - - HYPH cord-002728-6oyw5sqv 133 29 host host NN cord-002728-6oyw5sqv 133 30 interactions interaction NNS cord-002728-6oyw5sqv 133 31 or or CC cord-002728-6oyw5sqv 133 32 host host NN cord-002728-6oyw5sqv 133 33 ranges range NNS cord-002728-6oyw5sqv 133 34 , , , cord-002728-6oyw5sqv 133 35 limiting limit VBG cord-002728-6oyw5sqv 133 36 in in IN cord-002728-6oyw5sqv 133 37 - - HYPH cord-002728-6oyw5sqv 133 38 depth depth NN cord-002728-6oyw5sqv 133 39 analyses analysis NNS cord-002728-6oyw5sqv 133 40 of of IN cord-002728-6oyw5sqv 133 41 the the DT cord-002728-6oyw5sqv 133 42 overall overall JJ cord-002728-6oyw5sqv 133 43 ecology ecology NN cord-002728-6oyw5sqv 133 44 of of IN cord-002728-6oyw5sqv 133 45 the the DT cord-002728-6oyw5sqv 133 46 gut gut NN cord-002728-6oyw5sqv 133 47 microbiome microbiome NN cord-002728-6oyw5sqv 133 48 . . . cord-002728-6oyw5sqv 134 1 21 21 CD cord-002728-6oyw5sqv 135 1 Studying study VBG cord-002728-6oyw5sqv 135 2 total total JJ cord-002728-6oyw5sqv 135 3 community community NN cord-002728-6oyw5sqv 135 4 metagenomes metagenome VBZ cord-002728-6oyw5sqv 135 5 in in IN cord-002728-6oyw5sqv 135 6 conjunction conjunction NN cord-002728-6oyw5sqv 135 7 with with IN cord-002728-6oyw5sqv 135 8 VLP VLP NNP cord-002728-6oyw5sqv 135 9 - - HYPH cord-002728-6oyw5sqv 135 10 derived derive VBN cord-002728-6oyw5sqv 135 11 metagenomes metagenomes NNP cord-002728-6oyw5sqv 135 12 will will MD cord-002728-6oyw5sqv 135 13 provide provide VB cord-002728-6oyw5sqv 135 14 a a DT cord-002728-6oyw5sqv 135 15 more more RBR cord-002728-6oyw5sqv 135 16 - - HYPH cord-002728-6oyw5sqv 135 17 complete complete JJ cord-002728-6oyw5sqv 135 18 picture picture NN cord-002728-6oyw5sqv 135 19 of of IN cord-002728-6oyw5sqv 135 20 virus virus NN cord-002728-6oyw5sqv 135 21 - - HYPH cord-002728-6oyw5sqv 135 22 host host NN cord-002728-6oyw5sqv 135 23 interactions interaction NNS cord-002728-6oyw5sqv 135 24 in in IN cord-002728-6oyw5sqv 135 25 the the DT cord-002728-6oyw5sqv 135 26 human human JJ cord-002728-6oyw5sqv 135 27 gut gut NN cord-002728-6oyw5sqv 135 28 . . . cord-002728-6oyw5sqv 136 1 21 21 CD cord-002728-6oyw5sqv 137 1 The the DT cord-002728-6oyw5sqv 137 2 greatest great JJS cord-002728-6oyw5sqv 137 3 challenge challenge NN cord-002728-6oyw5sqv 137 4 to to IN cord-002728-6oyw5sqv 137 5 integrated integrate VBN cord-002728-6oyw5sqv 137 6 studies study NNS cord-002728-6oyw5sqv 137 7 of of IN cord-002728-6oyw5sqv 137 8 the the DT cord-002728-6oyw5sqv 137 9 whole whole JJ cord-002728-6oyw5sqv 137 10 gut gut NN cord-002728-6oyw5sqv 137 11 microbiome microbiome NN cord-002728-6oyw5sqv 137 12 is be VBZ cord-002728-6oyw5sqv 137 13 71 71 CD cord-002728-6oyw5sqv 138 1 It -PRON- PRP cord-002728-6oyw5sqv 138 2 has have VBZ cord-002728-6oyw5sqv 138 3 been be VBN cord-002728-6oyw5sqv 138 4 stated state VBN cord-002728-6oyw5sqv 138 5 that that IN cord-002728-6oyw5sqv 138 6 isolating isolate VBG cord-002728-6oyw5sqv 138 7 " " `` cord-002728-6oyw5sqv 138 8 just just RB cord-002728-6oyw5sqv 138 9 a a DT cord-002728-6oyw5sqv 138 10 few few JJ cord-002728-6oyw5sqv 138 11 phage phage NN cord-002728-6oyw5sqv 138 12 genomes genome NNS cord-002728-6oyw5sqv 138 13 from from IN cord-002728-6oyw5sqv 138 14 novel novel JJ cord-002728-6oyw5sqv 138 15 environments environment NNS cord-002728-6oyw5sqv 138 16 will will MD cord-002728-6oyw5sqv 138 17 greatly greatly RB cord-002728-6oyw5sqv 138 18 increase increase VB cord-002728-6oyw5sqv 138 19 our -PRON- PRP$ cord-002728-6oyw5sqv 138 20 understanding understanding NN cord-002728-6oyw5sqv 138 21 of of IN cord-002728-6oyw5sqv 138 22 viral viral JJ cord-002728-6oyw5sqv 138 23 diversity diversity NN cord-002728-6oyw5sqv 138 24 in in IN cord-002728-6oyw5sqv 138 25 these these DT cord-002728-6oyw5sqv 138 26 environments environment NNS cord-002728-6oyw5sqv 138 27 " " '' cord-002728-6oyw5sqv 138 28 . . . cord-002728-6oyw5sqv 139 1 72 72 CD cord-002728-6oyw5sqv 139 2 ( ( -LRB- cord-002728-6oyw5sqv 139 3 2 2 LS cord-002728-6oyw5sqv 139 4 ) ) -RRB- cord-002728-6oyw5sqv 139 5 there there EX cord-002728-6oyw5sqv 139 6 are be VBP cord-002728-6oyw5sqv 139 7 a a DT cord-002728-6oyw5sqv 139 8 number number NN cord-002728-6oyw5sqv 139 9 of of IN cord-002728-6oyw5sqv 139 10 medical medical JJ cord-002728-6oyw5sqv 139 11 conditions condition NNS cord-002728-6oyw5sqv 139 12 speculated speculate VBN cord-002728-6oyw5sqv 139 13 to to TO cord-002728-6oyw5sqv 139 14 be be VB cord-002728-6oyw5sqv 139 15 linked link VBN cord-002728-6oyw5sqv 139 16 with with IN cord-002728-6oyw5sqv 139 17 viral viral JJ cord-002728-6oyw5sqv 139 18 infections infection NNS cord-002728-6oyw5sqv 139 19 ( ( -LRB- cord-002728-6oyw5sqv 139 20 eg eg UH cord-002728-6oyw5sqv 139 21 , , , cord-002728-6oyw5sqv 139 22 type type NN cord-002728-6oyw5sqv 139 23 I -PRON- PRP cord-002728-6oyw5sqv 139 24 diabetes diabete VBZ cord-002728-6oyw5sqv 139 25 , , , cord-002728-6oyw5sqv 139 26 chronic chronic JJ cord-002728-6oyw5sqv 139 27 fatigue fatigue NN cord-002728-6oyw5sqv 139 28 syndrome syndrome NN cord-002728-6oyw5sqv 139 29 , , , cord-002728-6oyw5sqv 139 30 obesity obesity NN cord-002728-6oyw5sqv 139 31 ) ) -RRB- cord-002728-6oyw5sqv 139 32 but but CC cord-002728-6oyw5sqv 139 33 for for IN cord-002728-6oyw5sqv 139 34 which which WDT cord-002728-6oyw5sqv 139 35 no no DT cord-002728-6oyw5sqv 139 36 infectious infectious JJ cord-002728-6oyw5sqv 139 37 agent agent NN cord-002728-6oyw5sqv 139 38 has have VBZ cord-002728-6oyw5sqv 139 39 been be VBN cord-002728-6oyw5sqv 139 40 found find VBN cord-002728-6oyw5sqv 139 41 . . . cord-002728-6oyw5sqv 140 1 It -PRON- PRP cord-002728-6oyw5sqv 140 2 has have VBZ cord-002728-6oyw5sqv 140 3 been be VBN cord-002728-6oyw5sqv 140 4 estimated estimate VBN cord-002728-6oyw5sqv 140 5 over over IN cord-002728-6oyw5sqv 140 6 half half DT cord-002728-6oyw5sqv 140 7 of of IN cord-002728-6oyw5sqv 140 8 humaninfecting humaninfecte VBG cord-002728-6oyw5sqv 140 9 viruses virus NNS cord-002728-6oyw5sqv 140 10 remain remain VBP cord-002728-6oyw5sqv 140 11 to to TO cord-002728-6oyw5sqv 140 12 be be VB cord-002728-6oyw5sqv 140 13 discovered discover VBN cord-002728-6oyw5sqv 140 14 . . . cord-002728-6oyw5sqv 141 1 76 76 CD cord-002728-6oyw5sqv 141 2 Interactions interaction NNS cord-002728-6oyw5sqv 141 3 with with IN cord-002728-6oyw5sqv 141 4 pets pet NNS cord-002728-6oyw5sqv 141 5 , , , cord-002728-6oyw5sqv 141 6 insects insect NNS cord-002728-6oyw5sqv 141 7 and and CC cord-002728-6oyw5sqv 141 8 wild wild JJ cord-002728-6oyw5sqv 141 9 animals animal NNS cord-002728-6oyw5sqv 141 10 will will MD cord-002728-6oyw5sqv 141 11 also also RB cord-002728-6oyw5sqv 141 12 influence influence VB cord-002728-6oyw5sqv 141 13 the the DT cord-002728-6oyw5sqv 141 14 composition composition NN cord-002728-6oyw5sqv 141 15 of of IN cord-002728-6oyw5sqv 141 16 the the DT cord-002728-6oyw5sqv 141 17 human human JJ cord-002728-6oyw5sqv 141 18 virome virome NN cord-002728-6oyw5sqv 141 19 . . . cord-002728-6oyw5sqv 142 1 From from IN cord-002728-6oyw5sqv 142 2 a a DT cord-002728-6oyw5sqv 142 3 pathogen pathogen NN cord-002728-6oyw5sqv 142 4 perspective perspective NN cord-002728-6oyw5sqv 142 5 , , , cord-002728-6oyw5sqv 142 6 bush bush NNP cord-002728-6oyw5sqv 142 7 - - HYPH cord-002728-6oyw5sqv 142 8 workers worker NNS cord-002728-6oyw5sqv 142 9 , , , cord-002728-6oyw5sqv 142 10 abattoir abattoir NN cord-002728-6oyw5sqv 142 11 workers worker NNS cord-002728-6oyw5sqv 142 12 and and CC cord-002728-6oyw5sqv 142 13 individuals individual NNS cord-002728-6oyw5sqv 142 14 exposed expose VBN cord-002728-6oyw5sqv 142 15 to to IN cord-002728-6oyw5sqv 142 16 insect insect NN cord-002728-6oyw5sqv 142 17 bites bite NNS cord-002728-6oyw5sqv 142 18 have have VBP cord-002728-6oyw5sqv 142 19 been be VBN cord-002728-6oyw5sqv 142 20 highlighted highlight VBN cord-002728-6oyw5sqv 142 21 as as IN cord-002728-6oyw5sqv 142 22 likely likely JJ cord-002728-6oyw5sqv 142 23 sources source NNS cord-002728-6oyw5sqv 142 24 of of IN cord-002728-6oyw5sqv 142 25 new new JJ cord-002728-6oyw5sqv 142 26 humaninfecting humaninfecting NN cord-002728-6oyw5sqv 142 27 viruses virus NNS cord-002728-6oyw5sqv 142 28 . . . cord-002728-6oyw5sqv 143 1 75 75 CD cord-002728-6oyw5sqv 144 1 With with IN cord-002728-6oyw5sqv 144 2 the the DT cord-002728-6oyw5sqv 144 3 advent advent NN cord-002728-6oyw5sqv 144 4 of of IN cord-002728-6oyw5sqv 144 5 high high JJ cord-002728-6oyw5sqv 144 6 - - HYPH cord-002728-6oyw5sqv 144 7 throughput throughput NN cord-002728-6oyw5sqv 144 8 , , , cord-002728-6oyw5sqv 144 9 inexpensive inexpensive JJ cord-002728-6oyw5sqv 144 10 , , , cord-002728-6oyw5sqv 144 11 sensitive sensitive JJ cord-002728-6oyw5sqv 144 12 sequencing sequencing NN cord-002728-6oyw5sqv 144 13 methods method NNS cord-002728-6oyw5sqv 144 14 , , , cord-002728-6oyw5sqv 144 15 it -PRON- PRP cord-002728-6oyw5sqv 144 16 has have VBZ cord-002728-6oyw5sqv 144 17 become become VBN cord-002728-6oyw5sqv 144 18 possible possible JJ cord-002728-6oyw5sqv 144 19 to to TO cord-002728-6oyw5sqv 144 20 study study VB cord-002728-6oyw5sqv 144 21 the the DT cord-002728-6oyw5sqv 144 22 contribution contribution NN cord-002728-6oyw5sqv 144 23 of of IN cord-002728-6oyw5sqv 144 24 dsDNA dsdna NN cord-002728-6oyw5sqv 144 25 , , , cord-002728-6oyw5sqv 144 26 ssDNA ssdna JJ cord-002728-6oyw5sqv 144 27 and and CC cord-002728-6oyw5sqv 144 28 RNA RNA NNP cord-002728-6oyw5sqv 144 29 VLPs vlp NNS cord-002728-6oyw5sqv 144 30 to to IN cord-002728-6oyw5sqv 144 31 the the DT cord-002728-6oyw5sqv 144 32 human human JJ cord-002728-6oyw5sqv 144 33 virome virome NN cord-002728-6oyw5sqv 144 34 . . . cord-002728-6oyw5sqv 145 1 Gene gene NN cord-002728-6oyw5sqv 145 2 transfer transfer NN cord-002728-6oyw5sqv 145 3 agents agent NNS cord-002728-6oyw5sqv 145 4 , , , cord-002728-6oyw5sqv 145 5 which which WDT cord-002728-6oyw5sqv 145 6 appear appear VBP cord-002728-6oyw5sqv 145 7 to to TO cord-002728-6oyw5sqv 145 8 represent represent VB cord-002728-6oyw5sqv 145 9 defective defective JJ cord-002728-6oyw5sqv 145 10 phages phage NNS cord-002728-6oyw5sqv 145 11 , , , cord-002728-6oyw5sqv 145 12 have have VBP cord-002728-6oyw5sqv 145 13 not not RB cord-002728-6oyw5sqv 145 14 been be VBN cord-002728-6oyw5sqv 145 15 examined examine VBN cord-002728-6oyw5sqv 145 16 in in IN cord-002728-6oyw5sqv 145 17 the the DT cord-002728-6oyw5sqv 145 18 context context NN cord-002728-6oyw5sqv 145 19 of of IN cord-002728-6oyw5sqv 145 20 the the DT cord-002728-6oyw5sqv 145 21 human human JJ cord-002728-6oyw5sqv 145 22 microbiome microbiome NN cord-002728-6oyw5sqv 145 23 or or CC cord-002728-6oyw5sqv 145 24 virome virome NN cord-002728-6oyw5sqv 145 25 , , , cord-002728-6oyw5sqv 145 26 but but CC cord-002728-6oyw5sqv 145 27 may may MD cord-002728-6oyw5sqv 145 28 also also RB cord-002728-6oyw5sqv 145 29 make make VB cord-002728-6oyw5sqv 145 30 a a DT cord-002728-6oyw5sqv 145 31 contribution contribution NN cord-002728-6oyw5sqv 145 32 to to IN cord-002728-6oyw5sqv 145 33 its -PRON- PRP$ cord-002728-6oyw5sqv 145 34 genetic genetic JJ cord-002728-6oyw5sqv 145 35 content content NN cord-002728-6oyw5sqv 145 36 . . . cord-002728-6oyw5sqv 146 1 77 77 CD cord-002728-6oyw5sqv 146 2 , , , cord-002728-6oyw5sqv 146 3 78 78 CD cord-002728-6oyw5sqv 147 1 Similarly similarly RB cord-002728-6oyw5sqv 147 2 , , , cord-002728-6oyw5sqv 147 3 exosomes exosome VBN cord-002728-6oyw5sqv 147 4 - - HYPH cord-002728-6oyw5sqv 147 5 extracellular extracellular JJ cord-002728-6oyw5sqv 147 6 vesicles vesicle NNS cord-002728-6oyw5sqv 147 7 of of IN cord-002728-6oyw5sqv 147 8 40 40 CD cord-002728-6oyw5sqv 147 9 - - SYM cord-002728-6oyw5sqv 147 10 100 100 CD cord-002728-6oyw5sqv 147 11 nm nm NN cord-002728-6oyw5sqv 147 12 in in IN cord-002728-6oyw5sqv 147 13 diameter diameter NN cord-002728-6oyw5sqv 147 14 consisting consist VBG cord-002728-6oyw5sqv 147 15 of of IN cord-002728-6oyw5sqv 147 16 proteins protein NNS cord-002728-6oyw5sqv 147 17 , , , cord-002728-6oyw5sqv 147 18 lipids lipid NNS cord-002728-6oyw5sqv 147 19 , , , cord-002728-6oyw5sqv 147 20 miRNA miRNA NNP cord-002728-6oyw5sqv 147 21 , , , cord-002728-6oyw5sqv 147 22 mRNA mRNA NNP cord-002728-6oyw5sqv 147 23 and and CC cord-002728-6oyw5sqv 147 24 DNA dna NN cord-002728-6oyw5sqv 147 25 - - HYPH cord-002728-6oyw5sqv 147 26 derived derive VBN cord-002728-6oyw5sqv 147 27 from from IN cord-002728-6oyw5sqv 147 28 cells cell NNS cord-002728-6oyw5sqv 147 29 lining line VBG cord-002728-6oyw5sqv 147 30 the the DT cord-002728-6oyw5sqv 147 31 GI GI NNP cord-002728-6oyw5sqv 147 32 epithelium epithelium NN cord-002728-6oyw5sqv 147 33 are be VBP cord-002728-6oyw5sqv 147 34 likely likely JJ cord-002728-6oyw5sqv 147 35 to to TO cord-002728-6oyw5sqv 147 36 contribute contribute VB cord-002728-6oyw5sqv 147 37 to to IN cord-002728-6oyw5sqv 147 38 nucleic nucleic JJ cord-002728-6oyw5sqv 147 39 acids acid NNS cord-002728-6oyw5sqv 147 40 found find VBN cord-002728-6oyw5sqv 147 41 in in IN cord-002728-6oyw5sqv 147 42 viromes virome NNS cord-002728-6oyw5sqv 147 43 . . . cord-002728-6oyw5sqv 148 1 79 79 CD cord-002728-6oyw5sqv 148 2 , , , cord-002728-6oyw5sqv 148 3 80 80 CD cord-002728-6oyw5sqv 148 4 Outer outer JJ cord-002728-6oyw5sqv 148 5 - - HYPH cord-002728-6oyw5sqv 148 6 membrane membrane NN cord-002728-6oyw5sqv 148 7 vesicles vesicle NNS cord-002728-6oyw5sqv 148 8 , , , cord-002728-6oyw5sqv 148 9 the the DT cord-002728-6oyw5sqv 148 10 equivalent equivalent NN cord-002728-6oyw5sqv 148 11 ( ( -LRB- cord-002728-6oyw5sqv 148 12 in in IN cord-002728-6oyw5sqv 148 13 size size NN cord-002728-6oyw5sqv 148 14 and and CC cord-002728-6oyw5sqv 148 15 composition composition NN cord-002728-6oyw5sqv 148 16 ) ) -RRB- cord-002728-6oyw5sqv 148 17 of of IN cord-002728-6oyw5sqv 148 18 eukaryotic eukaryotic JJ cord-002728-6oyw5sqv 148 19 exosomes exosome NNS cord-002728-6oyw5sqv 148 20 for for IN cord-002728-6oyw5sqv 148 21 Gram gram NN cord-002728-6oyw5sqv 148 22 - - HYPH cord-002728-6oyw5sqv 148 23 negative negative JJ cord-002728-6oyw5sqv 148 24 bacteria bacteria NNS cord-002728-6oyw5sqv 148 25 , , , cord-002728-6oyw5sqv 148 26 may may MD cord-002728-6oyw5sqv 148 27 also also RB cord-002728-6oyw5sqv 148 28 contribute contribute VB cord-002728-6oyw5sqv 148 29 to to IN cord-002728-6oyw5sqv 148 30 what what WP cord-002728-6oyw5sqv 148 31 we -PRON- PRP cord-002728-6oyw5sqv 148 32 currently currently RB cord-002728-6oyw5sqv 148 33 call call VBP cord-002728-6oyw5sqv 148 34 the the DT cord-002728-6oyw5sqv 148 35 virome virome NN cord-002728-6oyw5sqv 148 36 , , , cord-002728-6oyw5sqv 148 37 as as IN cord-002728-6oyw5sqv 148 38 these these DT cord-002728-6oyw5sqv 148 39 vesicles vesicle NNS cord-002728-6oyw5sqv 148 40 have have VBP cord-002728-6oyw5sqv 148 41 recently recently RB cord-002728-6oyw5sqv 148 42 been be VBN cord-002728-6oyw5sqv 148 43 reported report VBN cord-002728-6oyw5sqv 148 44 to to TO cord-002728-6oyw5sqv 148 45 contain contain VB cord-002728-6oyw5sqv 148 46 DNA DNA NNP cord-002728-6oyw5sqv 148 47 as as RB cord-002728-6oyw5sqv 148 48 well well RB cord-002728-6oyw5sqv 148 49 as as IN cord-002728-6oyw5sqv 148 50 RNA RNA NNP cord-002728-6oyw5sqv 148 51 . . . cord-002728-6oyw5sqv 149 1 81 81 CD cord-002728-6oyw5sqv 149 2 _SP cord-002728-6oyw5sqv 150 1 Whereas whereas IN cord-002728-6oyw5sqv 150 2 16S 16S NNP cord-002728-6oyw5sqv 150 3 rRNA rrna NN cord-002728-6oyw5sqv 150 4 gene gene NN cord-002728-6oyw5sqv 150 5 sequence sequence NN cord-002728-6oyw5sqv 150 6 data datum NNS cord-002728-6oyw5sqv 150 7 are be VBP cord-002728-6oyw5sqv 150 8 readily readily RB cord-002728-6oyw5sqv 150 9 processed process VBN cord-002728-6oyw5sqv 150 10 and and CC cord-002728-6oyw5sqv 150 11 analysed analyse VBN cord-002728-6oyw5sqv 150 12 using use VBG cord-002728-6oyw5sqv 150 13 packages package NNS cord-002728-6oyw5sqv 150 14 such such JJ cord-002728-6oyw5sqv 150 15 as as IN cord-002728-6oyw5sqv 150 16 QIIME QIIME NNP cord-002728-6oyw5sqv 150 17 and and CC cord-002728-6oyw5sqv 150 18 Mothur Mothur NNP cord-002728-6oyw5sqv 150 19 , , , cord-002728-6oyw5sqv 150 20 no no DT cord-002728-6oyw5sqv 150 21 such such JJ cord-002728-6oyw5sqv 150 22 tools tool NNS cord-002728-6oyw5sqv 150 23 exist exist VBP cord-002728-6oyw5sqv 150 24 for for IN cord-002728-6oyw5sqv 150 25 the the DT cord-002728-6oyw5sqv 150 26 analyses analysis NNS cord-002728-6oyw5sqv 150 27 of of IN cord-002728-6oyw5sqv 150 28 sequence sequence NN cord-002728-6oyw5sqv 150 29 data datum NNS cord-002728-6oyw5sqv 150 30 derived derive VBN cord-002728-6oyw5sqv 150 31 from from IN cord-002728-6oyw5sqv 150 32 host host NN cord-002728-6oyw5sqv 150 33 - - HYPH cord-002728-6oyw5sqv 150 34 associated associate VBN cord-002728-6oyw5sqv 150 35 viromes virome NNS cord-002728-6oyw5sqv 150 36 . . . cord-002728-6oyw5sqv 151 1 35 35 CD cord-002728-6oyw5sqv 151 2 Tools tool NNS cord-002728-6oyw5sqv 151 3 exist exist VBP cord-002728-6oyw5sqv 151 4 for for IN cord-002728-6oyw5sqv 151 5 functional functional JJ cord-002728-6oyw5sqv 151 6 annotation annotation NN cord-002728-6oyw5sqv 151 7 of of IN cord-002728-6oyw5sqv 151 8 viromes virome NNS cord-002728-6oyw5sqv 151 9 and and CC cord-002728-6oyw5sqv 151 10 estimating estimate VBG cord-002728-6oyw5sqv 151 11 viral viral JJ cord-002728-6oyw5sqv 151 12 diversity diversity NN cord-002728-6oyw5sqv 151 13 ( ( -LRB- cord-002728-6oyw5sqv 151 14 Table Table NNP cord-002728-6oyw5sqv 151 15 3 3 CD cord-002728-6oyw5sqv 151 16 ) ) -RRB- cord-002728-6oyw5sqv 151 17 . . . cord-002728-6oyw5sqv 152 1 No no DT cord-002728-6oyw5sqv 152 2 easy easy JJ cord-002728-6oyw5sqv 152 3 - - HYPH cord-002728-6oyw5sqv 152 4 to to IN cord-002728-6oyw5sqv 152 5 - - HYPH cord-002728-6oyw5sqv 152 6 use use NN cord-002728-6oyw5sqv 152 7 pipeline pipeline NN cord-002728-6oyw5sqv 152 8 that that WDT cord-002728-6oyw5sqv 152 9 takes take VBZ cord-002728-6oyw5sqv 152 10 raw raw JJ cord-002728-6oyw5sqv 152 11 reads read NNS cord-002728-6oyw5sqv 152 12 , , , cord-002728-6oyw5sqv 152 13 strips strip VBZ cord-002728-6oyw5sqv 152 14 out out RP cord-002728-6oyw5sqv 152 15 host host NN cord-002728-6oyw5sqv 152 16 DNA dna NN cord-002728-6oyw5sqv 152 17 , , , cord-002728-6oyw5sqv 152 18 looks look VBZ cord-002728-6oyw5sqv 152 19 for for IN cord-002728-6oyw5sqv 152 20 bacterial bacterial JJ cord-002728-6oyw5sqv 152 21 contaminants contaminant NNS cord-002728-6oyw5sqv 152 22 then then RB cord-002728-6oyw5sqv 152 23 assigns assign VBZ cord-002728-6oyw5sqv 152 24 taxonomy taxonomy NN cord-002728-6oyw5sqv 152 25 and and CC cord-002728-6oyw5sqv 152 26 functionality functionality NN cord-002728-6oyw5sqv 152 27 to to IN cord-002728-6oyw5sqv 152 28 prokaryote prokaryote NN cord-002728-6oyw5sqv 152 29 and and CC cord-002728-6oyw5sqv 152 30 eukaryote eukaryote NN cord-002728-6oyw5sqv 152 31 viruses virus NNS cord-002728-6oyw5sqv 152 32 within within IN cord-002728-6oyw5sqv 152 33 samples sample NNS cord-002728-6oyw5sqv 153 1 exists exist VBZ cord-002728-6oyw5sqv 153 2 , , , cord-002728-6oyw5sqv 153 3 though though IN cord-002728-6oyw5sqv 153 4 efforts effort NNS cord-002728-6oyw5sqv 153 5 are be VBP cord-002728-6oyw5sqv 153 6 being be VBG cord-002728-6oyw5sqv 153 7 made make VBN cord-002728-6oyw5sqv 153 8 to to TO cord-002728-6oyw5sqv 153 9 generate generate VB cord-002728-6oyw5sqv 153 10 such such JJ cord-002728-6oyw5sqv 153 11 tools tool NNS cord-002728-6oyw5sqv 153 12 . . . cord-002728-6oyw5sqv 154 1 These these DT cord-002728-6oyw5sqv 154 2 will will MD cord-002728-6oyw5sqv 154 3 need need VB cord-002728-6oyw5sqv 154 4 to to TO cord-002728-6oyw5sqv 154 5 take take VB cord-002728-6oyw5sqv 154 6 into into IN cord-002728-6oyw5sqv 154 7 account account NN cord-002728-6oyw5sqv 154 8 the the DT cord-002728-6oyw5sqv 154 9 presence presence NN cord-002728-6oyw5sqv 154 10 of of IN cord-002728-6oyw5sqv 154 11 human human JJ cord-002728-6oyw5sqv 154 12 endogenous endogenous JJ cord-002728-6oyw5sqv 154 13 retroviruses retrovirus NNS cord-002728-6oyw5sqv 154 14 , , , cord-002728-6oyw5sqv 154 15 which which WDT cord-002728-6oyw5sqv 154 16 comprise~8 comprise~8 VBZ cord-002728-6oyw5sqv 154 17 % % NN cord-002728-6oyw5sqv 154 18 of of IN cord-002728-6oyw5sqv 154 19 the the DT cord-002728-6oyw5sqv 154 20 human human JJ cord-002728-6oyw5sqv 154 21 genome genome NN cord-002728-6oyw5sqv 154 22 and and CC cord-002728-6oyw5sqv 154 23 still still RB cord-002728-6oyw5sqv 154 24 possess possess VB cord-002728-6oyw5sqv 154 25 the the DT cord-002728-6oyw5sqv 154 26 ability ability NN cord-002728-6oyw5sqv 154 27 to to TO cord-002728-6oyw5sqv 154 28 encode encode VB cord-002728-6oyw5sqv 154 29 retrovirus retrovirus NN cord-002728-6oyw5sqv 154 30 polymerase polymerase NN cord-002728-6oyw5sqv 154 31 and and CC cord-002728-6oyw5sqv 154 32 envelope envelope NN cord-002728-6oyw5sqv 154 33 protein protein NN cord-002728-6oyw5sqv 154 34 and and CC cord-002728-6oyw5sqv 154 35 can can MD cord-002728-6oyw5sqv 154 36 be be VB cord-002728-6oyw5sqv 154 37 reactivated reactivate VBN cord-002728-6oyw5sqv 154 38 by by IN cord-002728-6oyw5sqv 154 39 exogenous exogenous JJ cord-002728-6oyw5sqv 154 40 retroviruses retrovirus NNS cord-002728-6oyw5sqv 154 41 such such JJ cord-002728-6oyw5sqv 154 42 as as IN cord-002728-6oyw5sqv 154 43 HIV HIV NNP cord-002728-6oyw5sqv 154 44 . . . cord-002728-6oyw5sqv 155 1 53 53 CD cord-002728-6oyw5sqv 155 2 _SP cord-002728-6oyw5sqv 156 1 The the DT cord-002728-6oyw5sqv 156 2 authors author NNS cord-002728-6oyw5sqv 156 3 would would MD cord-002728-6oyw5sqv 156 4 like like VB cord-002728-6oyw5sqv 156 5 to to TO cord-002728-6oyw5sqv 156 6 thank thank VB cord-002728-6oyw5sqv 156 7 Sam Sam NNP cord-002728-6oyw5sqv 156 8 Carding Carding NNP cord-002728-6oyw5sqv 156 9 for for IN cord-002728-6oyw5sqv 156 10 creating create VBG cord-002728-6oyw5sqv 156 11 Figure figure NN cord-002728-6oyw5sqv 156 12 1 1 CD cord-002728-6oyw5sqv 156 13 . . . cord-002728-6oyw5sqv 157 1 Declaration declaration NN cord-002728-6oyw5sqv 157 2 of of IN cord-002728-6oyw5sqv 157 3 personal personal JJ cord-002728-6oyw5sqv 157 4 interest interest NN cord-002728-6oyw5sqv 157 5 : : : cord-002728-6oyw5sqv 157 6 None none NN cord-002728-6oyw5sqv 157 7 . . . cord-002728-6oyw5sqv 157 8 _SP cord-002728-6oyw5sqv 158 1 Here here RB cord-002728-6oyw5sqv 158 2 a a DT cord-002728-6oyw5sqv 158 3 virus virus NN cord-002728-6oyw5sqv 158 4 , , , cord-002728-6oyw5sqv 158 5 there there EX cord-002728-6oyw5sqv 158 6 a a DT cord-002728-6oyw5sqv 158 7 virus virus NN cord-002728-6oyw5sqv 158 8 , , , cord-002728-6oyw5sqv 158 9 everywhere everywhere RB cord-002728-6oyw5sqv 158 10 the the DT cord-002728-6oyw5sqv 158 11 same same JJ cord-002728-6oyw5sqv 158 12 virus virus NN cord-002728-6oyw5sqv 158 13 ? ? . cord-002728-6oyw5sqv 159 1 Viral viral JJ cord-002728-6oyw5sqv 159 2 ecology ecology NN cord-002728-6oyw5sqv 159 3 comes come VBZ cord-002728-6oyw5sqv 159 4 of of IN cord-002728-6oyw5sqv 159 5 age age NN cord-002728-6oyw5sqv 159 6 . . . cord-002728-6oyw5sqv 160 1 Environ Environ NNP cord-002728-6oyw5sqv 160 2 Microbiol Microbiol NNP cord-002728-6oyw5sqv 160 3 Rep Rep NNP cord-002728-6oyw5sqv 160 4 Exploiting exploit VBG cord-002728-6oyw5sqv 160 5 gut gut NN cord-002728-6oyw5sqv 160 6 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 160 7 for for IN cord-002728-6oyw5sqv 160 8 human human JJ cord-002728-6oyw5sqv 160 9 health health NN cord-002728-6oyw5sqv 160 10 Characterization characterization NN cord-002728-6oyw5sqv 160 11 of of IN cord-002728-6oyw5sqv 160 12 a a DT cord-002728-6oyw5sqv 160 13 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 160 14 - - HYPH cord-002728-6oyw5sqv 160 15 derived derive VBN cord-002728-6oyw5sqv 160 16 murein murein JJ cord-002728-6oyw5sqv 160 17 peptidase peptidase NN cord-002728-6oyw5sqv 160 18 for for IN cord-002728-6oyw5sqv 160 19 elimination elimination NN cord-002728-6oyw5sqv 160 20 of of IN cord-002728-6oyw5sqv 160 21 antibiotic antibiotic JJ cord-002728-6oyw5sqv 160 22 - - HYPH cord-002728-6oyw5sqv 160 23 resistant resistant JJ cord-002728-6oyw5sqv 160 24 Staphylococcus Staphylococcus NNP cord-002728-6oyw5sqv 160 25 aureus aureus NN cord-002728-6oyw5sqv 160 26 Ecology Ecology NNP cord-002728-6oyw5sqv 160 27 of of IN cord-002728-6oyw5sqv 160 28 prokaryotic prokaryotic JJ cord-002728-6oyw5sqv 160 29 viruses virus NNS cord-002728-6oyw5sqv 160 30 Bacteriophage bacteriophage NN cord-002728-6oyw5sqv 160 31 receptors receptor NNS cord-002728-6oyw5sqv 160 32 , , , cord-002728-6oyw5sqv 160 33 mechanisms mechanism NNS cord-002728-6oyw5sqv 160 34 of of IN cord-002728-6oyw5sqv 160 35 phage phage NN cord-002728-6oyw5sqv 160 36 adsorption adsorption NN cord-002728-6oyw5sqv 160 37 and and CC cord-002728-6oyw5sqv 160 38 penetration penetration NN cord-002728-6oyw5sqv 160 39 into into IN cord-002728-6oyw5sqv 160 40 host host NN cord-002728-6oyw5sqv 160 41 cell cell NN cord-002728-6oyw5sqv 160 42 Comparative Comparative NNP cord-002728-6oyw5sqv 160 43 ( ( -LRB- cord-002728-6oyw5sqv 160 44 meta)genomic meta)genomic NNP cord-002728-6oyw5sqv 160 45 analysis analysis NN cord-002728-6oyw5sqv 160 46 and and CC cord-002728-6oyw5sqv 160 47 ecological ecological JJ cord-002728-6oyw5sqv 160 48 profiling profiling NN cord-002728-6oyw5sqv 160 49 of of IN cord-002728-6oyw5sqv 160 50 human human JJ cord-002728-6oyw5sqv 160 51 gut gut NN cord-002728-6oyw5sqv 160 52 - - HYPH cord-002728-6oyw5sqv 160 53 specific specific JJ cord-002728-6oyw5sqv 160 54 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 160 55 φB124 φb124 CD cord-002728-6oyw5sqv 160 56 - - HYPH cord-002728-6oyw5sqv 160 57 14 14 CD cord-002728-6oyw5sqv 160 58 CRISPR CRISPR NNP cord-002728-6oyw5sqv 160 59 targeting targeting NN cord-002728-6oyw5sqv 160 60 reveals reveal VBZ cord-002728-6oyw5sqv 160 61 a a DT cord-002728-6oyw5sqv 160 62 reservoir reservoir NN cord-002728-6oyw5sqv 160 63 of of IN cord-002728-6oyw5sqv 160 64 common common JJ cord-002728-6oyw5sqv 160 65 phages phage NNS cord-002728-6oyw5sqv 160 66 associated associate VBN cord-002728-6oyw5sqv 160 67 with with IN cord-002728-6oyw5sqv 160 68 the the DT cord-002728-6oyw5sqv 160 69 human human JJ cord-002728-6oyw5sqv 160 70 gut gut NN cord-002728-6oyw5sqv 160 71 microbiome microbiome NN cord-002728-6oyw5sqv 160 72 Dysbiosis Dysbiosis NNP cord-002728-6oyw5sqv 160 73 in in IN cord-002728-6oyw5sqv 160 74 inflammatory inflammatory JJ cord-002728-6oyw5sqv 160 75 bowel bowel NN cord-002728-6oyw5sqv 160 76 disease disease NN cord-002728-6oyw5sqv 160 77 : : : cord-002728-6oyw5sqv 160 78 a a DT cord-002728-6oyw5sqv 160 79 role role NN cord-002728-6oyw5sqv 160 80 for for IN cord-002728-6oyw5sqv 160 81 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 160 82 ? ? . cord-002728-6oyw5sqv 161 1 Characterization characterization NN cord-002728-6oyw5sqv 161 2 of of IN cord-002728-6oyw5sqv 161 3 viruslike viruslike JJ cord-002728-6oyw5sqv 161 4 particles particle NNS cord-002728-6oyw5sqv 161 5 associated associate VBN cord-002728-6oyw5sqv 161 6 with with IN cord-002728-6oyw5sqv 161 7 the the DT cord-002728-6oyw5sqv 161 8 human human JJ cord-002728-6oyw5sqv 161 9 faecal faecal JJ cord-002728-6oyw5sqv 161 10 and and CC cord-002728-6oyw5sqv 161 11 caecal caecal JJ cord-002728-6oyw5sqv 161 12 microbiota microbiota NN cord-002728-6oyw5sqv 161 13 Diversity diversity NN cord-002728-6oyw5sqv 161 14 and and CC cord-002728-6oyw5sqv 161 15 abundance abundance NN cord-002728-6oyw5sqv 161 16 of of IN cord-002728-6oyw5sqv 161 17 single single RB cord-002728-6oyw5sqv 161 18 - - HYPH cord-002728-6oyw5sqv 161 19 stranded strand VBN cord-002728-6oyw5sqv 161 20 DNA dna NN cord-002728-6oyw5sqv 161 21 viruses virus NNS cord-002728-6oyw5sqv 161 22 in in IN cord-002728-6oyw5sqv 161 23 human human JJ cord-002728-6oyw5sqv 161 24 feces fece NNS cord-002728-6oyw5sqv 161 25 Optimizing optimize VBG cord-002728-6oyw5sqv 161 26 protocols protocol NNS cord-002728-6oyw5sqv 161 27 for for IN cord-002728-6oyw5sqv 161 28 extraction extraction NN cord-002728-6oyw5sqv 161 29 of of IN cord-002728-6oyw5sqv 161 30 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 161 31 prior prior RB cord-002728-6oyw5sqv 161 32 to to IN cord-002728-6oyw5sqv 161 33 metagenomic metagenomic NNP cord-002728-6oyw5sqv 161 34 analyses analysis NNS cord-002728-6oyw5sqv 161 35 of of IN cord-002728-6oyw5sqv 161 36 phage phage NN cord-002728-6oyw5sqv 161 37 communities community NNS cord-002728-6oyw5sqv 161 38 in in IN cord-002728-6oyw5sqv 161 39 the the DT cord-002728-6oyw5sqv 161 40 human human JJ cord-002728-6oyw5sqv 161 41 gut gut NN cord-002728-6oyw5sqv 161 42 Virome Virome NNP cord-002728-6oyw5sqv 161 43 capture capture NN cord-002728-6oyw5sqv 161 44 sequencing sequencing NN cord-002728-6oyw5sqv 161 45 enables enable VBZ cord-002728-6oyw5sqv 161 46 sensitive sensitive JJ cord-002728-6oyw5sqv 161 47 viral viral JJ cord-002728-6oyw5sqv 161 48 diagnosis diagnosis NN cord-002728-6oyw5sqv 161 49 and and CC cord-002728-6oyw5sqv 161 50 comprehensive comprehensive JJ cord-002728-6oyw5sqv 161 51 virome virome NN cord-002728-6oyw5sqv 161 52 analysis analysis NN cord-002728-6oyw5sqv 161 53 Metagenomics Metagenomics NNPS cord-002728-6oyw5sqv 161 54 : : : cord-002728-6oyw5sqv 162 1 genomic genomic JJ cord-002728-6oyw5sqv 162 2 analysis analysis NN cord-002728-6oyw5sqv 162 3 of of IN cord-002728-6oyw5sqv 162 4 microbial microbial JJ cord-002728-6oyw5sqv 162 5 communities community NNS cord-002728-6oyw5sqv 162 6 Richness Richness NNP cord-002728-6oyw5sqv 162 7 of of IN cord-002728-6oyw5sqv 162 8 human human JJ cord-002728-6oyw5sqv 162 9 gut gut NN cord-002728-6oyw5sqv 162 10 microbiome microbiome NN cord-002728-6oyw5sqv 162 11 correlates correlate VBZ cord-002728-6oyw5sqv 162 12 with with IN cord-002728-6oyw5sqv 162 13 metabolic metabolic JJ cord-002728-6oyw5sqv 162 14 markers marker NNS cord-002728-6oyw5sqv 162 15 Dietary dietary JJ cord-002728-6oyw5sqv 162 16 intervention intervention NN cord-002728-6oyw5sqv 162 17 impact impact NN cord-002728-6oyw5sqv 162 18 on on IN cord-002728-6oyw5sqv 162 19 gut gut NN cord-002728-6oyw5sqv 162 20 microbial microbial JJ cord-002728-6oyw5sqv 162 21 gene gene NN cord-002728-6oyw5sqv 163 1 richness richness NNP cord-002728-6oyw5sqv 163 2 Alterations alteration NNS cord-002728-6oyw5sqv 163 3 of of IN cord-002728-6oyw5sqv 163 4 the the DT cord-002728-6oyw5sqv 163 5 human human JJ cord-002728-6oyw5sqv 163 6 gut gut NN cord-002728-6oyw5sqv 163 7 microbiome microbiome NN cord-002728-6oyw5sqv 163 8 in in IN cord-002728-6oyw5sqv 163 9 liver liver NN cord-002728-6oyw5sqv 163 10 cirrhosis cirrhosis NN cord-002728-6oyw5sqv 163 11 Shotgun shotgun NN cord-002728-6oyw5sqv 163 12 metagenomics metagenomic NNS cord-002728-6oyw5sqv 163 13 of of IN cord-002728-6oyw5sqv 163 14 250 250 CD cord-002728-6oyw5sqv 163 15 adult adult NN cord-002728-6oyw5sqv 163 16 twins twin NNS cord-002728-6oyw5sqv 163 17 reveals reveal VBZ cord-002728-6oyw5sqv 163 18 genetic genetic JJ cord-002728-6oyw5sqv 163 19 and and CC cord-002728-6oyw5sqv 163 20 environmental environmental JJ cord-002728-6oyw5sqv 163 21 impacts impact NNS cord-002728-6oyw5sqv 163 22 on on IN cord-002728-6oyw5sqv 163 23 the the DT cord-002728-6oyw5sqv 163 24 gut gut NN cord-002728-6oyw5sqv 163 25 microbiome microbiome NN cord-002728-6oyw5sqv 164 1 Metagenomic Metagenomic NNP cord-002728-6oyw5sqv 164 2 analyses analysis NNS cord-002728-6oyw5sqv 164 3 of of IN cord-002728-6oyw5sqv 164 4 an an DT cord-002728-6oyw5sqv 164 5 uncultured uncultured JJ cord-002728-6oyw5sqv 164 6 viral viral JJ cord-002728-6oyw5sqv 164 7 community community NN cord-002728-6oyw5sqv 164 8 from from IN cord-002728-6oyw5sqv 164 9 human human JJ cord-002728-6oyw5sqv 164 10 feces fece NNS cord-002728-6oyw5sqv 165 1 The the DT cord-002728-6oyw5sqv 165 2 human human JJ cord-002728-6oyw5sqv 165 3 gut gut NN cord-002728-6oyw5sqv 165 4 virome virome NNP cord-002728-6oyw5sqv 165 5 : : : cord-002728-6oyw5sqv 165 6 inter inter JJ cord-002728-6oyw5sqv 165 7 - - JJ cord-002728-6oyw5sqv 165 8 individual individual JJ cord-002728-6oyw5sqv 165 9 variation variation NN cord-002728-6oyw5sqv 165 10 and and CC cord-002728-6oyw5sqv 165 11 dynamic dynamic JJ cord-002728-6oyw5sqv 165 12 response response NN cord-002728-6oyw5sqv 165 13 to to IN cord-002728-6oyw5sqv 165 14 diet diet NNP cord-002728-6oyw5sqv 165 15 Genome Genome NNP cord-002728-6oyw5sqv 165 16 signature signature NN cord-002728-6oyw5sqv 165 17 - - HYPH cord-002728-6oyw5sqv 165 18 based base VBN cord-002728-6oyw5sqv 165 19 dissection dissection NN cord-002728-6oyw5sqv 165 20 of of IN cord-002728-6oyw5sqv 165 21 human human JJ cord-002728-6oyw5sqv 165 22 gut gut NN cord-002728-6oyw5sqv 165 23 metagenomes metagenome NNS cord-002728-6oyw5sqv 165 24 to to TO cord-002728-6oyw5sqv 165 25 extract extract VB cord-002728-6oyw5sqv 165 26 subliminal subliminal JJ cord-002728-6oyw5sqv 165 27 viral viral JJ cord-002728-6oyw5sqv 165 28 sequences sequence NNS cord-002728-6oyw5sqv 165 29 A a DT cord-002728-6oyw5sqv 165 30 highly highly RB cord-002728-6oyw5sqv 165 31 abundant abundant JJ cord-002728-6oyw5sqv 165 32 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 165 33 discovered discover VBN cord-002728-6oyw5sqv 165 34 in in IN cord-002728-6oyw5sqv 165 35 the the DT cord-002728-6oyw5sqv 165 36 unknown unknown JJ cord-002728-6oyw5sqv 165 37 sequences sequence NNS cord-002728-6oyw5sqv 165 38 of of IN cord-002728-6oyw5sqv 165 39 human human JJ cord-002728-6oyw5sqv 165 40 faecal faecal JJ cord-002728-6oyw5sqv 165 41 metagenomes metagenomes NNP cord-002728-6oyw5sqv 166 1 The the DT cord-002728-6oyw5sqv 166 2 application application NN cord-002728-6oyw5sqv 166 3 of of IN cord-002728-6oyw5sqv 166 4 a a DT cord-002728-6oyw5sqv 166 5 recently recently RB cord-002728-6oyw5sqv 166 6 isolated isolate VBN cord-002728-6oyw5sqv 166 7 strain strain NN cord-002728-6oyw5sqv 166 8 of of IN cord-002728-6oyw5sqv 166 9 Bacteroides Bacteroides NNP cord-002728-6oyw5sqv 166 10 ( ( -LRB- cord-002728-6oyw5sqv 166 11 GB-124 GB-124 NNP cord-002728-6oyw5sqv 166 12 ) ) -RRB- cord-002728-6oyw5sqv 166 13 to to TO cord-002728-6oyw5sqv 166 14 identify identify VB cord-002728-6oyw5sqv 166 15 human human JJ cord-002728-6oyw5sqv 166 16 sources source NNS cord-002728-6oyw5sqv 166 17 of of IN cord-002728-6oyw5sqv 166 18 faecal faecal JJ cord-002728-6oyw5sqv 166 19 pollution pollution NN cord-002728-6oyw5sqv 166 20 in in IN cord-002728-6oyw5sqv 166 21 a a DT cord-002728-6oyw5sqv 166 22 temperate temperate JJ cord-002728-6oyw5sqv 166 23 river river NN cord-002728-6oyw5sqv 166 24 catchment catchment NN cord-002728-6oyw5sqv 166 25 Evolution evolution NN cord-002728-6oyw5sqv 166 26 and and CC cord-002728-6oyw5sqv 166 27 diversity diversity NN cord-002728-6oyw5sqv 166 28 of of IN cord-002728-6oyw5sqv 166 29 the the DT cord-002728-6oyw5sqv 166 30 Microviridae Microviridae NNP cord-002728-6oyw5sqv 166 31 viral viral JJ cord-002728-6oyw5sqv 166 32 family family NN cord-002728-6oyw5sqv 166 33 through through IN cord-002728-6oyw5sqv 166 34 a a DT cord-002728-6oyw5sqv 166 35 collection collection NN cord-002728-6oyw5sqv 166 36 of of IN cord-002728-6oyw5sqv 166 37 81 81 CD cord-002728-6oyw5sqv 166 38 new new JJ cord-002728-6oyw5sqv 166 39 complete complete JJ cord-002728-6oyw5sqv 166 40 genomes genome NNS cord-002728-6oyw5sqv 166 41 assembled assemble VBN cord-002728-6oyw5sqv 166 42 from from IN cord-002728-6oyw5sqv 166 43 virome virome NNP cord-002728-6oyw5sqv 166 44 reads read VBZ cord-002728-6oyw5sqv 166 45 New new JJ cord-002728-6oyw5sqv 166 46 viruses virus NNS cord-002728-6oyw5sqv 166 47 in in IN cord-002728-6oyw5sqv 166 48 idiopathic idiopathic JJ cord-002728-6oyw5sqv 166 49 human human JJ cord-002728-6oyw5sqv 166 50 diarrhea diarrhea NN cord-002728-6oyw5sqv 166 51 cases case NNS cord-002728-6oyw5sqv 166 52 , , , cord-002728-6oyw5sqv 166 53 the the DT cord-002728-6oyw5sqv 166 54 Netherlands Netherlands NNP cord-002728-6oyw5sqv 166 55 Viral Viral NNP cord-002728-6oyw5sqv 166 56 metagenomics metagenomic NNS cord-002728-6oyw5sqv 166 57 applied apply VBN cord-002728-6oyw5sqv 166 58 to to IN cord-002728-6oyw5sqv 166 59 blood blood NN cord-002728-6oyw5sqv 166 60 donors donor NNS cord-002728-6oyw5sqv 166 61 and and CC cord-002728-6oyw5sqv 166 62 recipients recipient NNS cord-002728-6oyw5sqv 166 63 at at IN cord-002728-6oyw5sqv 166 64 high high JJ cord-002728-6oyw5sqv 166 65 risk risk NN cord-002728-6oyw5sqv 166 66 for for IN cord-002728-6oyw5sqv 166 67 blood blood NN cord-002728-6oyw5sqv 166 68 - - HYPH cord-002728-6oyw5sqv 166 69 borne bear VBN cord-002728-6oyw5sqv 166 70 infections infection NNS cord-002728-6oyw5sqv 166 71 Viruses virus NNS cord-002728-6oyw5sqv 166 72 in in IN cord-002728-6oyw5sqv 166 73 the the DT cord-002728-6oyw5sqv 166 74 faecal faecal JJ cord-002728-6oyw5sqv 166 75 microbiota microbiota NN cord-002728-6oyw5sqv 166 76 of of IN cord-002728-6oyw5sqv 166 77 monozygotic monozygotic JJ cord-002728-6oyw5sqv 166 78 twins twin NNS cord-002728-6oyw5sqv 166 79 and and CC cord-002728-6oyw5sqv 166 80 their -PRON- PRP$ cord-002728-6oyw5sqv 166 81 mothers mother NNS cord-002728-6oyw5sqv 166 82 Healthy healthy JJ cord-002728-6oyw5sqv 166 83 human human JJ cord-002728-6oyw5sqv 166 84 gut gut NN cord-002728-6oyw5sqv 166 85 phageome phageome NN cord-002728-6oyw5sqv 166 86 Disease Disease NNP cord-002728-6oyw5sqv 166 87 - - HYPH cord-002728-6oyw5sqv 166 88 specific specific JJ cord-002728-6oyw5sqv 166 89 alterations alteration NNS cord-002728-6oyw5sqv 166 90 in in IN cord-002728-6oyw5sqv 166 91 the the DT cord-002728-6oyw5sqv 166 92 enteric enteric JJ cord-002728-6oyw5sqv 166 93 virome virome NN cord-002728-6oyw5sqv 166 94 in in IN cord-002728-6oyw5sqv 166 95 inflammatory inflammatory JJ cord-002728-6oyw5sqv 166 96 bowel bowel NN cord-002728-6oyw5sqv 166 97 disease disease NN cord-002728-6oyw5sqv 167 1 The the DT cord-002728-6oyw5sqv 167 2 human human JJ cord-002728-6oyw5sqv 167 3 gut gut NN cord-002728-6oyw5sqv 167 4 phage phage NN cord-002728-6oyw5sqv 167 5 community community NN cord-002728-6oyw5sqv 167 6 and and CC cord-002728-6oyw5sqv 167 7 its -PRON- PRP$ cord-002728-6oyw5sqv 167 8 implications implication NNS cord-002728-6oyw5sqv 167 9 for for IN cord-002728-6oyw5sqv 167 10 health health NN cord-002728-6oyw5sqv 167 11 and and CC cord-002728-6oyw5sqv 167 12 disease disease NN cord-002728-6oyw5sqv 167 13 Hypervariable hypervariable JJ cord-002728-6oyw5sqv 167 14 loci locus NNS cord-002728-6oyw5sqv 167 15 in in IN cord-002728-6oyw5sqv 167 16 the the DT cord-002728-6oyw5sqv 167 17 human human JJ cord-002728-6oyw5sqv 167 18 gut gut NN cord-002728-6oyw5sqv 167 19 virome virome NN cord-002728-6oyw5sqv 167 20 Viral viral JJ cord-002728-6oyw5sqv 167 21 diversity diversity NN cord-002728-6oyw5sqv 167 22 and and CC cord-002728-6oyw5sqv 167 23 dynamics dynamic NNS cord-002728-6oyw5sqv 167 24 in in IN cord-002728-6oyw5sqv 167 25 an an DT cord-002728-6oyw5sqv 167 26 infant infant NN cord-002728-6oyw5sqv 167 27 gut gut NN cord-002728-6oyw5sqv 167 28 Rapid rapid JJ cord-002728-6oyw5sqv 167 29 evolution evolution NN cord-002728-6oyw5sqv 167 30 of of IN cord-002728-6oyw5sqv 167 31 the the DT cord-002728-6oyw5sqv 167 32 human human JJ cord-002728-6oyw5sqv 167 33 gut gut NN cord-002728-6oyw5sqv 167 34 virome virome NNP cord-002728-6oyw5sqv 167 35 Bacteriophage Bacteriophage NNP cord-002728-6oyw5sqv 167 36 adhering adhere VBG cord-002728-6oyw5sqv 167 37 to to IN cord-002728-6oyw5sqv 167 38 mucus mucus NN cord-002728-6oyw5sqv 167 39 provide provide VB cord-002728-6oyw5sqv 167 40 a a DT cord-002728-6oyw5sqv 167 41 non non JJ cord-002728-6oyw5sqv 167 42 - - JJ cord-002728-6oyw5sqv 167 43 host host JJ cord-002728-6oyw5sqv 167 44 - - HYPH cord-002728-6oyw5sqv 167 45 derived derive VBN cord-002728-6oyw5sqv 167 46 immunity immunity NN cord-002728-6oyw5sqv 167 47 Effects effect NNS cord-002728-6oyw5sqv 167 48 of of IN cord-002728-6oyw5sqv 167 49 long long JJ cord-002728-6oyw5sqv 167 50 term term NN cord-002728-6oyw5sqv 167 51 antibiotic antibiotic JJ cord-002728-6oyw5sqv 167 52 therapy therapy NN cord-002728-6oyw5sqv 167 53 on on IN cord-002728-6oyw5sqv 167 54 human human JJ cord-002728-6oyw5sqv 167 55 oral oral JJ cord-002728-6oyw5sqv 167 56 and and CC cord-002728-6oyw5sqv 167 57 fecal fecal JJ cord-002728-6oyw5sqv 167 58 viromes virome NNS cord-002728-6oyw5sqv 168 1 Quinolone Quinolone NNP cord-002728-6oyw5sqv 168 2 antibiotics antibiotic NNS cord-002728-6oyw5sqv 168 3 induce induce VBP cord-002728-6oyw5sqv 168 4 Shiga Shiga NNP cord-002728-6oyw5sqv 168 5 toxin toxin NN cord-002728-6oyw5sqv 168 6 - - HYPH cord-002728-6oyw5sqv 168 7 encoding encode VBG cord-002728-6oyw5sqv 168 8 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 168 9 , , , cord-002728-6oyw5sqv 168 10 toxin toxin NN cord-002728-6oyw5sqv 168 11 production production NN cord-002728-6oyw5sqv 168 12 , , , cord-002728-6oyw5sqv 168 13 and and CC cord-002728-6oyw5sqv 168 14 death death NN cord-002728-6oyw5sqv 168 15 in in IN cord-002728-6oyw5sqv 168 16 mice mouse NNS cord-002728-6oyw5sqv 168 17 Metagenomic Metagenomic NNP cord-002728-6oyw5sqv 168 18 analysis analysis NN cord-002728-6oyw5sqv 168 19 of of IN cord-002728-6oyw5sqv 168 20 respiratory respiratory JJ cord-002728-6oyw5sqv 168 21 tract tract NN cord-002728-6oyw5sqv 168 22 DNA dna NN cord-002728-6oyw5sqv 168 23 viral viral JJ cord-002728-6oyw5sqv 168 24 communities community NNS cord-002728-6oyw5sqv 168 25 in in IN cord-002728-6oyw5sqv 168 26 cystic cystic JJ cord-002728-6oyw5sqv 168 27 fibrosis fibrosis NN cord-002728-6oyw5sqv 168 28 and and CC cord-002728-6oyw5sqv 169 1 non non JJ cord-002728-6oyw5sqv 169 2 - - JJ cord-002728-6oyw5sqv 169 3 cystic cystic JJ cord-002728-6oyw5sqv 169 4 fibrosis fibrosis NN cord-002728-6oyw5sqv 169 5 individuals individual NNS cord-002728-6oyw5sqv 169 6 Transmission Transmission NNP cord-002728-6oyw5sqv 169 7 of of IN cord-002728-6oyw5sqv 169 8 viruses virus NNS cord-002728-6oyw5sqv 169 9 via via IN cord-002728-6oyw5sqv 169 10 our -PRON- PRP$ cord-002728-6oyw5sqv 169 11 microbiomes microbiome NNS cord-002728-6oyw5sqv 169 12 Phages Phages NNPS cord-002728-6oyw5sqv 169 13 rarely rarely RB cord-002728-6oyw5sqv 169 14 encode encode VBP cord-002728-6oyw5sqv 169 15 antibiotic antibiotic JJ cord-002728-6oyw5sqv 169 16 resistance resistance NN cord-002728-6oyw5sqv 169 17 genes gene NNS cord-002728-6oyw5sqv 169 18 : : : cord-002728-6oyw5sqv 169 19 a a DT cord-002728-6oyw5sqv 169 20 cautionary cautionary JJ cord-002728-6oyw5sqv 169 21 tale tale NN cord-002728-6oyw5sqv 169 22 for for IN cord-002728-6oyw5sqv 169 23 virome virome NN cord-002728-6oyw5sqv 169 24 analyses analyse VBZ cord-002728-6oyw5sqv 169 25 Single Single NNP cord-002728-6oyw5sqv 169 26 - - HYPH cord-002728-6oyw5sqv 169 27 stranded strand VBN cord-002728-6oyw5sqv 169 28 DNA dna NN cord-002728-6oyw5sqv 169 29 library library NN cord-002728-6oyw5sqv 169 30 preparation preparation NN cord-002728-6oyw5sqv 169 31 for for IN cord-002728-6oyw5sqv 169 32 the the DT cord-002728-6oyw5sqv 169 33 sequencing sequencing NN cord-002728-6oyw5sqv 169 34 of of IN cord-002728-6oyw5sqv 169 35 ancient ancient JJ cord-002728-6oyw5sqv 169 36 or or CC cord-002728-6oyw5sqv 169 37 damaged damaged JJ cord-002728-6oyw5sqv 169 38 DNA DNA NNP cord-002728-6oyw5sqv 169 39 Structure Structure NNP cord-002728-6oyw5sqv 169 40 and and CC cord-002728-6oyw5sqv 169 41 diversity diversity NN cord-002728-6oyw5sqv 169 42 of of IN cord-002728-6oyw5sqv 169 43 ssDNA ssDNA VBG cord-002728-6oyw5sqv 169 44 Microviridae Microviridae NNP cord-002728-6oyw5sqv 169 45 viruses virus NNS cord-002728-6oyw5sqv 169 46 in in IN cord-002728-6oyw5sqv 169 47 two two CD cord-002728-6oyw5sqv 169 48 peri peri JJ cord-002728-6oyw5sqv 169 49 - - HYPH cord-002728-6oyw5sqv 169 50 alpine alpine JJ cord-002728-6oyw5sqv 169 51 lakes lake NNS cord-002728-6oyw5sqv 169 52 ( ( -LRB- cord-002728-6oyw5sqv 169 53 Annecy Annecy NNP cord-002728-6oyw5sqv 169 54 and and CC cord-002728-6oyw5sqv 169 55 Bourget Bourget NNP cord-002728-6oyw5sqv 169 56 , , , cord-002728-6oyw5sqv 169 57 France France NNP cord-002728-6oyw5sqv 169 58 ) ) -RRB- cord-002728-6oyw5sqv 170 1 Towards towards IN cord-002728-6oyw5sqv 170 2 quantitative quantitative JJ cord-002728-6oyw5sqv 170 3 viromics viromic NNS cord-002728-6oyw5sqv 170 4 for for IN cord-002728-6oyw5sqv 170 5 both both DT cord-002728-6oyw5sqv 170 6 double double RB cord-002728-6oyw5sqv 170 7 - - HYPH cord-002728-6oyw5sqv 170 8 stranded stranded JJ cord-002728-6oyw5sqv 170 9 and and CC cord-002728-6oyw5sqv 170 10 single single RB cord-002728-6oyw5sqv 170 11 - - HYPH cord-002728-6oyw5sqv 170 12 stranded strand VBN cord-002728-6oyw5sqv 170 13 DNA dna NN cord-002728-6oyw5sqv 170 14 viruses virus NNS cord-002728-6oyw5sqv 170 15 Distribution distribution NN cord-002728-6oyw5sqv 170 16 of of IN cord-002728-6oyw5sqv 170 17 ribonucleic ribonucleic JJ cord-002728-6oyw5sqv 170 18 acid acid NN cord-002728-6oyw5sqv 170 19 coliphages coliphage NNS cord-002728-6oyw5sqv 170 20 in in IN cord-002728-6oyw5sqv 170 21 animals animal NNS cord-002728-6oyw5sqv 170 22 RNA RNA NNP cord-002728-6oyw5sqv 170 23 viral viral JJ cord-002728-6oyw5sqv 170 24 community community NN cord-002728-6oyw5sqv 170 25 in in IN cord-002728-6oyw5sqv 170 26 human human JJ cord-002728-6oyw5sqv 170 27 feces fece NNS cord-002728-6oyw5sqv 170 28 : : : cord-002728-6oyw5sqv 170 29 prevalence prevalence NN cord-002728-6oyw5sqv 170 30 of of IN cord-002728-6oyw5sqv 170 31 plant plant NN cord-002728-6oyw5sqv 170 32 pathogenic pathogenic JJ cord-002728-6oyw5sqv 170 33 viruses virus NNS cord-002728-6oyw5sqv 170 34 Direct direct JJ cord-002728-6oyw5sqv 170 35 metagenomic metagenomic JJ cord-002728-6oyw5sqv 170 36 detection detection NN cord-002728-6oyw5sqv 170 37 of of IN cord-002728-6oyw5sqv 170 38 viral viral JJ cord-002728-6oyw5sqv 170 39 pathogens pathogen NNS cord-002728-6oyw5sqv 170 40 in in IN cord-002728-6oyw5sqv 170 41 nasal nasal NN cord-002728-6oyw5sqv 170 42 and and CC cord-002728-6oyw5sqv 170 43 fecal fecal JJ cord-002728-6oyw5sqv 170 44 specimens specimen NNS cord-002728-6oyw5sqv 170 45 using use VBG cord-002728-6oyw5sqv 170 46 an an DT cord-002728-6oyw5sqv 170 47 unbiased unbiased JJ cord-002728-6oyw5sqv 170 48 high high JJ cord-002728-6oyw5sqv 170 49 - - HYPH cord-002728-6oyw5sqv 170 50 throughput throughput NN cord-002728-6oyw5sqv 170 51 sequencing sequencing NN cord-002728-6oyw5sqv 170 52 approach approach NN cord-002728-6oyw5sqv 170 53 Early early JJ cord-002728-6oyw5sqv 170 54 life life NN cord-002728-6oyw5sqv 170 55 dynamics dynamic NNS cord-002728-6oyw5sqv 170 56 of of IN cord-002728-6oyw5sqv 170 57 the the DT cord-002728-6oyw5sqv 170 58 human human JJ cord-002728-6oyw5sqv 170 59 gut gut NN cord-002728-6oyw5sqv 170 60 virome virome NN cord-002728-6oyw5sqv 170 61 and and CC cord-002728-6oyw5sqv 170 62 bacterial bacterial JJ cord-002728-6oyw5sqv 170 63 microbiome microbiome NN cord-002728-6oyw5sqv 170 64 in in IN cord-002728-6oyw5sqv 170 65 infants infant NNS cord-002728-6oyw5sqv 171 1 Longitudinal longitudinal JJ cord-002728-6oyw5sqv 171 2 investigation investigation NN cord-002728-6oyw5sqv 171 3 of of IN cord-002728-6oyw5sqv 171 4 the the DT cord-002728-6oyw5sqv 171 5 faecal faecal JJ cord-002728-6oyw5sqv 171 6 microbiota microbiota NN cord-002728-6oyw5sqv 171 7 of of IN cord-002728-6oyw5sqv 171 8 healthy healthy JJ cord-002728-6oyw5sqv 171 9 full full JJ cord-002728-6oyw5sqv 171 10 - - HYPH cord-002728-6oyw5sqv 171 11 term term NN cord-002728-6oyw5sqv 171 12 infants infant NNS cord-002728-6oyw5sqv 171 13 using use VBG cord-002728-6oyw5sqv 171 14 fluorescence fluorescence NN cord-002728-6oyw5sqv 171 15 in in IN cord-002728-6oyw5sqv 171 16 situ situ NN cord-002728-6oyw5sqv 171 17 hybridization hybridization NN cord-002728-6oyw5sqv 171 18 and and CC cord-002728-6oyw5sqv 171 19 denaturing denature VBG cord-002728-6oyw5sqv 171 20 gradient gradient NN cord-002728-6oyw5sqv 171 21 gel gel NN cord-002728-6oyw5sqv 171 22 electrophoresis electrophoresis NN cord-002728-6oyw5sqv 171 23 . . . cord-002728-6oyw5sqv 172 1 Microbiology Microbiology NNP cord-002728-6oyw5sqv 172 2 Improved Improved NNP cord-002728-6oyw5sqv 172 3 detection detection NN cord-002728-6oyw5sqv 172 4 of of IN cord-002728-6oyw5sqv 172 5 bifidobacteria bifidobacteria NNP cord-002728-6oyw5sqv 172 6 with with IN cord-002728-6oyw5sqv 172 7 optimised optimise VBN cord-002728-6oyw5sqv 172 8 16S 16S NNP cord-002728-6oyw5sqv 172 9 rRNA rrna NN cord-002728-6oyw5sqv 172 10 - - HYPH cord-002728-6oyw5sqv 172 11 gene gene NN cord-002728-6oyw5sqv 172 12 based base VBN cord-002728-6oyw5sqv 172 13 pyrosequencing pyrosequencing NNP cord-002728-6oyw5sqv 172 14 16S 16S NNP cord-002728-6oyw5sqv 172 15 rRNA rRNA NNP cord-002728-6oyw5sqv 172 16 gene gene NN cord-002728-6oyw5sqv 172 17 - - HYPH cord-002728-6oyw5sqv 172 18 based base VBN cord-002728-6oyw5sqv 172 19 profiling profiling NN cord-002728-6oyw5sqv 172 20 of of IN cord-002728-6oyw5sqv 172 21 the the DT cord-002728-6oyw5sqv 172 22 human human JJ cord-002728-6oyw5sqv 172 23 infant infant NN cord-002728-6oyw5sqv 172 24 gut gut NN cord-002728-6oyw5sqv 172 25 microbiota microbiota NN cord-002728-6oyw5sqv 172 26 is be VBZ cord-002728-6oyw5sqv 172 27 strongly strongly RB cord-002728-6oyw5sqv 172 28 influenced influence VBN cord-002728-6oyw5sqv 172 29 by by IN cord-002728-6oyw5sqv 172 30 sample sample NN cord-002728-6oyw5sqv 172 31 processing processing NN cord-002728-6oyw5sqv 172 32 and and CC cord-002728-6oyw5sqv 172 33 PCR PCR NNP cord-002728-6oyw5sqv 172 34 primer primer NN cord-002728-6oyw5sqv 172 35 choice choice NN cord-002728-6oyw5sqv 173 1 Gut gut NN cord-002728-6oyw5sqv 173 2 DNA dna NN cord-002728-6oyw5sqv 173 3 viromes virome NNS cord-002728-6oyw5sqv 173 4 of of IN cord-002728-6oyw5sqv 173 5 Malawian malawian JJ cord-002728-6oyw5sqv 173 6 twins twin NNS cord-002728-6oyw5sqv 173 7 discordant discordant JJ cord-002728-6oyw5sqv 173 8 for for IN cord-002728-6oyw5sqv 173 9 severe severe JJ cord-002728-6oyw5sqv 173 10 acute acute JJ cord-002728-6oyw5sqv 173 11 malnutrition malnutrition NN cord-002728-6oyw5sqv 173 12 Bacteriophage Bacteriophage NNP cord-002728-6oyw5sqv 173 13 translocation translocation NN cord-002728-6oyw5sqv 173 14 Altered alter VBD cord-002728-6oyw5sqv 173 15 virome virome NN cord-002728-6oyw5sqv 173 16 and and CC cord-002728-6oyw5sqv 173 17 bacterial bacterial JJ cord-002728-6oyw5sqv 173 18 microbiome microbiome NN cord-002728-6oyw5sqv 173 19 in in IN cord-002728-6oyw5sqv 173 20 human human JJ cord-002728-6oyw5sqv 173 21 immunodeficiency immunodeficiency NN cord-002728-6oyw5sqv 173 22 virus virus NN cord-002728-6oyw5sqv 173 23 - - HYPH cord-002728-6oyw5sqv 173 24 associated associate VBN cord-002728-6oyw5sqv 173 25 acquired acquire VBN cord-002728-6oyw5sqv 173 26 immunodeficiency immunodeficiency NN cord-002728-6oyw5sqv 173 27 syndrome syndrome NN cord-002728-6oyw5sqv 173 28 Detection detection NN cord-002728-6oyw5sqv 173 29 and and CC cord-002728-6oyw5sqv 173 30 identification identification NN cord-002728-6oyw5sqv 173 31 of of IN cord-002728-6oyw5sqv 173 32 plasma plasma NN cord-002728-6oyw5sqv 173 33 bacterial bacterial JJ cord-002728-6oyw5sqv 173 34 and and CC cord-002728-6oyw5sqv 173 35 viral viral JJ cord-002728-6oyw5sqv 173 36 elements element NNS cord-002728-6oyw5sqv 173 37 in in IN cord-002728-6oyw5sqv 173 38 HIV HIV NNP cord-002728-6oyw5sqv 173 39 / / SYM cord-002728-6oyw5sqv 173 40 AIDS AIDS NNP cord-002728-6oyw5sqv 173 41 patients patient NNS cord-002728-6oyw5sqv 173 42 in in IN cord-002728-6oyw5sqv 173 43 comparison comparison NN cord-002728-6oyw5sqv 173 44 to to IN cord-002728-6oyw5sqv 173 45 healthy healthy JJ cord-002728-6oyw5sqv 173 46 adults adult NNS cord-002728-6oyw5sqv 173 47 Method Method NNP cord-002728-6oyw5sqv 173 48 for for IN cord-002728-6oyw5sqv 173 49 discovering discover VBG cord-002728-6oyw5sqv 173 50 novel novel JJ cord-002728-6oyw5sqv 173 51 DNA dna NN cord-002728-6oyw5sqv 173 52 viruses virus NNS cord-002728-6oyw5sqv 173 53 in in IN cord-002728-6oyw5sqv 173 54 blood blood NN cord-002728-6oyw5sqv 173 55 using use VBG cord-002728-6oyw5sqv 173 56 viral viral JJ cord-002728-6oyw5sqv 173 57 particle particle NN cord-002728-6oyw5sqv 173 58 selection selection NN cord-002728-6oyw5sqv 173 59 and and CC cord-002728-6oyw5sqv 173 60 shotgun shotgun NN cord-002728-6oyw5sqv 173 61 sequencing sequence VBG cord-002728-6oyw5sqv 173 62 The the DT cord-002728-6oyw5sqv 173 63 antibody antibody NN cord-002728-6oyw5sqv 173 64 response response NN cord-002728-6oyw5sqv 173 65 to to IN cord-002728-6oyw5sqv 173 66 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 173 67 phi phi NNP cord-002728-6oyw5sqv 173 68 - - HYPH cord-002728-6oyw5sqv 173 69 X X NNP cord-002728-6oyw5sqv 173 70 174 174 CD cord-002728-6oyw5sqv 173 71 in in IN cord-002728-6oyw5sqv 173 72 newborn newborn JJ cord-002728-6oyw5sqv 173 73 premature premature JJ cord-002728-6oyw5sqv 173 74 infants infant NNS cord-002728-6oyw5sqv 173 75 Tumor tumor NN cord-002728-6oyw5sqv 173 76 - - HYPH cord-002728-6oyw5sqv 173 77 specific specific JJ cord-002728-6oyw5sqv 173 78 bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 173 79 induce induce VBP cord-002728-6oyw5sqv 173 80 tumor tumor NN cord-002728-6oyw5sqv 173 81 destruction destruction NN cord-002728-6oyw5sqv 173 82 through through IN cord-002728-6oyw5sqv 173 83 activation activation NN cord-002728-6oyw5sqv 173 84 of of IN cord-002728-6oyw5sqv 173 85 tumor tumor NN cord-002728-6oyw5sqv 173 86 - - HYPH cord-002728-6oyw5sqv 173 87 associated associate VBN cord-002728-6oyw5sqv 173 88 macrophages macrophage NNS cord-002728-6oyw5sqv 174 1 An an DT cord-002728-6oyw5sqv 174 2 enteric enteric JJ cord-002728-6oyw5sqv 174 3 virus virus NN cord-002728-6oyw5sqv 174 4 can can MD cord-002728-6oyw5sqv 174 5 replace replace VB cord-002728-6oyw5sqv 174 6 the the DT cord-002728-6oyw5sqv 174 7 beneficial beneficial JJ cord-002728-6oyw5sqv 174 8 function function NN cord-002728-6oyw5sqv 174 9 of of IN cord-002728-6oyw5sqv 174 10 commensal commensal JJ cord-002728-6oyw5sqv 174 11 bacteria bacteria NNS cord-002728-6oyw5sqv 174 12 Efficacy Efficacy NNP cord-002728-6oyw5sqv 174 13 of of IN cord-002728-6oyw5sqv 174 14 sterile sterile JJ cord-002728-6oyw5sqv 174 15 fecal fecal JJ cord-002728-6oyw5sqv 174 16 filtrate filtrate NN cord-002728-6oyw5sqv 174 17 transfer transfer NN cord-002728-6oyw5sqv 174 18 for for IN cord-002728-6oyw5sqv 174 19 treating treat VBG cord-002728-6oyw5sqv 174 20 patients patient NNS cord-002728-6oyw5sqv 174 21 with with IN cord-002728-6oyw5sqv 174 22 Clostridium clostridium NN cord-002728-6oyw5sqv 174 23 difficile difficile NN cord-002728-6oyw5sqv 174 24 infection infection NN cord-002728-6oyw5sqv 174 25 Bacteriophage Bacteriophage NNP cord-002728-6oyw5sqv 174 26 transfer transfer NN cord-002728-6oyw5sqv 174 27 during during IN cord-002728-6oyw5sqv 174 28 faecal faecal JJ cord-002728-6oyw5sqv 174 29 microbiota microbiota NN cord-002728-6oyw5sqv 174 30 transplantation transplantation NN cord-002728-6oyw5sqv 174 31 in in IN cord-002728-6oyw5sqv 174 32 Clostridium clostridium NN cord-002728-6oyw5sqv 174 33 difficile difficile NN cord-002728-6oyw5sqv 174 34 infection infection NN cord-002728-6oyw5sqv 174 35 is be VBZ cord-002728-6oyw5sqv 174 36 associated associate VBN cord-002728-6oyw5sqv 174 37 with with IN cord-002728-6oyw5sqv 174 38 treatment treatment NN cord-002728-6oyw5sqv 174 39 outcome outcome NN cord-002728-6oyw5sqv 174 40 Virus virus NN cord-002728-6oyw5sqv 174 41 - - HYPH cord-002728-6oyw5sqv 174 42 plus plus CC cord-002728-6oyw5sqv 174 43 - - HYPH cord-002728-6oyw5sqv 174 44 susceptibility susceptibility NN cord-002728-6oyw5sqv 174 45 gene gene NN cord-002728-6oyw5sqv 174 46 interaction interaction NN cord-002728-6oyw5sqv 174 47 determines determine VBZ cord-002728-6oyw5sqv 174 48 Crohn Crohn NNP cord-002728-6oyw5sqv 174 49 's 's POS cord-002728-6oyw5sqv 174 50 disease disease NN cord-002728-6oyw5sqv 174 51 gene gene NN cord-002728-6oyw5sqv 174 52 Atg16L1 Atg16L1 NNP cord-002728-6oyw5sqv 174 53 phenotypes phenotype NNS cord-002728-6oyw5sqv 174 54 in in IN cord-002728-6oyw5sqv 174 55 intestine intestine NN cord-002728-6oyw5sqv 174 56 Enteric enteric JJ cord-002728-6oyw5sqv 174 57 viruses virus NNS cord-002728-6oyw5sqv 174 58 ameliorate ameliorate VBP cord-002728-6oyw5sqv 174 59 gut gut NN cord-002728-6oyw5sqv 174 60 inflammation inflammation NN cord-002728-6oyw5sqv 174 61 via via IN cord-002728-6oyw5sqv 174 62 Toll toll NN cord-002728-6oyw5sqv 174 63 - - HYPH cord-002728-6oyw5sqv 174 64 like like JJ cord-002728-6oyw5sqv 174 65 receptor receptor NN cord-002728-6oyw5sqv 174 66 3 3 CD cord-002728-6oyw5sqv 174 67 and and CC cord-002728-6oyw5sqv 174 68 Toll Toll NNP cord-002728-6oyw5sqv 174 69 - - HYPH cord-002728-6oyw5sqv 174 70 like like JJ cord-002728-6oyw5sqv 174 71 receptor receptor NN cord-002728-6oyw5sqv 174 72 7-mediated 7-mediated CD cord-002728-6oyw5sqv 174 73 interferon interferon NN cord-002728-6oyw5sqv 174 74 - - HYPH cord-002728-6oyw5sqv 174 75 b b NN cord-002728-6oyw5sqv 174 76 production production NN cord-002728-6oyw5sqv 174 77 Bacteriophages bacteriophage NNS cord-002728-6oyw5sqv 174 78 in in IN cord-002728-6oyw5sqv 174 79 gut gut NN cord-002728-6oyw5sqv 174 80 samples sample NNS cord-002728-6oyw5sqv 174 81 from from IN cord-002728-6oyw5sqv 174 82 pediatric pediatric JJ cord-002728-6oyw5sqv 174 83 Crohn Crohn NNP cord-002728-6oyw5sqv 174 84 's 's POS cord-002728-6oyw5sqv 174 85 disease disease NN cord-002728-6oyw5sqv 174 86 patients patient NNS cord-002728-6oyw5sqv 174 87 : : : cord-002728-6oyw5sqv 174 88 metagenomic metagenomic NNP cord-002728-6oyw5sqv 174 89 analysis analysis NN cord-002728-6oyw5sqv 174 90 using use VBG cord-002728-6oyw5sqv 174 91 454 454 CD cord-002728-6oyw5sqv 174 92 pyrosequencing pyrosequencing NNP cord-002728-6oyw5sqv 174 93 Study Study NNP cord-002728-6oyw5sqv 174 94 of of IN cord-002728-6oyw5sqv 174 95 the the DT cord-002728-6oyw5sqv 174 96 viral viral JJ cord-002728-6oyw5sqv 174 97 and and CC cord-002728-6oyw5sqv 174 98 microbial microbial JJ cord-002728-6oyw5sqv 174 99 communities community NNS cord-002728-6oyw5sqv 174 100 associated associate VBN cord-002728-6oyw5sqv 174 101 with with IN cord-002728-6oyw5sqv 174 102 Crohn Crohn NNP cord-002728-6oyw5sqv 174 103 's 's POS cord-002728-6oyw5sqv 174 104 disease disease NN cord-002728-6oyw5sqv 174 105 : : : cord-002728-6oyw5sqv 174 106 a a DT cord-002728-6oyw5sqv 174 107 metagenomic metagenomic NN cord-002728-6oyw5sqv 174 108 approach approach NN cord-002728-6oyw5sqv 174 109 Metagenomic Metagenomic NNP cord-002728-6oyw5sqv 174 110 analysis analysis NN cord-002728-6oyw5sqv 174 111 of of IN cord-002728-6oyw5sqv 174 112 microbiome microbiome NN cord-002728-6oyw5sqv 174 113 in in IN cord-002728-6oyw5sqv 174 114 colon colon NN cord-002728-6oyw5sqv 174 115 tissue tissue NN cord-002728-6oyw5sqv 174 116 from from IN cord-002728-6oyw5sqv 174 117 subjects subject NNS cord-002728-6oyw5sqv 174 118 with with IN cord-002728-6oyw5sqv 174 119 inflammatory inflammatory JJ cord-002728-6oyw5sqv 174 120 bowel bowel NN cord-002728-6oyw5sqv 174 121 diseases disease NNS cord-002728-6oyw5sqv 174 122 reveals reveal VBZ cord-002728-6oyw5sqv 174 123 interplay interplay JJ cord-002728-6oyw5sqv 174 124 of of IN cord-002728-6oyw5sqv 174 125 viruses virus NNS cord-002728-6oyw5sqv 174 126 and and CC cord-002728-6oyw5sqv 174 127 bacteria bacteria NNS cord-002728-6oyw5sqv 174 128 Metagenomic Metagenomic NNP cord-002728-6oyw5sqv 174 129 analysis analysis NN cord-002728-6oyw5sqv 174 130 of of IN cord-002728-6oyw5sqv 174 131 Crohn Crohn NNP cord-002728-6oyw5sqv 174 132 's 's POS cord-002728-6oyw5sqv 174 133 disease disease NN cord-002728-6oyw5sqv 174 134 patients patient NNS cord-002728-6oyw5sqv 174 135 identifies identify VBZ cord-002728-6oyw5sqv 174 136 changes change NNS cord-002728-6oyw5sqv 174 137 in in IN cord-002728-6oyw5sqv 174 138 the the DT cord-002728-6oyw5sqv 174 139 virome virome NN cord-002728-6oyw5sqv 174 140 and and CC cord-002728-6oyw5sqv 174 141 microbiome microbiome NN cord-002728-6oyw5sqv 174 142 related relate VBN cord-002728-6oyw5sqv 174 143 to to IN cord-002728-6oyw5sqv 174 144 disease disease NN cord-002728-6oyw5sqv 174 145 status status NN cord-002728-6oyw5sqv 174 146 and and CC cord-002728-6oyw5sqv 174 147 therapy therapy NN cord-002728-6oyw5sqv 174 148 , , , cord-002728-6oyw5sqv 174 149 and and CC cord-002728-6oyw5sqv 174 150 detects detect VBZ cord-002728-6oyw5sqv 174 151 potential potential JJ cord-002728-6oyw5sqv 174 152 interactions interaction NNS cord-002728-6oyw5sqv 174 153 and and CC cord-002728-6oyw5sqv 174 154 biomarkers biomarker NNS cord-002728-6oyw5sqv 175 1 Modular modular JJ cord-002728-6oyw5sqv 175 2 approach approach NN cord-002728-6oyw5sqv 175 3 to to TO cord-002728-6oyw5sqv 175 4 customise customise VB cord-002728-6oyw5sqv 175 5 sample sample NN cord-002728-6oyw5sqv 175 6 preparation preparation NN cord-002728-6oyw5sqv 175 7 procedures procedure NNS cord-002728-6oyw5sqv 175 8 for for IN cord-002728-6oyw5sqv 175 9 viral viral JJ cord-002728-6oyw5sqv 175 10 metagenomics metagenomic NNS cord-002728-6oyw5sqv 175 11 : : : cord-002728-6oyw5sqv 175 12 a a DT cord-002728-6oyw5sqv 175 13 reproducible reproducible JJ cord-002728-6oyw5sqv 175 14 protocol protocol NN cord-002728-6oyw5sqv 175 15 for for IN cord-002728-6oyw5sqv 175 16 virome virome NNP cord-002728-6oyw5sqv 175 17 analysis analysis NN cord-002728-6oyw5sqv 175 18 Evaluation Evaluation NNP cord-002728-6oyw5sqv 175 19 of of IN cord-002728-6oyw5sqv 175 20 methods method NNS cord-002728-6oyw5sqv 175 21 to to TO cord-002728-6oyw5sqv 175 22 purify purify VB cord-002728-6oyw5sqv 175 23 virus virus NN cord-002728-6oyw5sqv 175 24 - - HYPH cord-002728-6oyw5sqv 175 25 like like JJ cord-002728-6oyw5sqv 175 26 particles particle NNS cord-002728-6oyw5sqv 175 27 for for IN cord-002728-6oyw5sqv 175 28 metagenomic metagenomic JJ cord-002728-6oyw5sqv 175 29 sequencing sequencing NN cord-002728-6oyw5sqv 175 30 of of IN cord-002728-6oyw5sqv 175 31 intestinal intestinal JJ cord-002728-6oyw5sqv 175 32 viromes virome NNS cord-002728-6oyw5sqv 176 1 The the DT cord-002728-6oyw5sqv 176 2 perioperative perioperative JJ cord-002728-6oyw5sqv 176 3 lung lung NN cord-002728-6oyw5sqv 176 4 transplant transplant NN cord-002728-6oyw5sqv 176 5 virome virome NNP cord-002728-6oyw5sqv 176 6 : : : cord-002728-6oyw5sqv 177 1 Torque Torque NNP cord-002728-6oyw5sqv 177 2 teno teno NNP cord-002728-6oyw5sqv 177 3 viruses virus NNS cord-002728-6oyw5sqv 177 4 are be VBP cord-002728-6oyw5sqv 177 5 elevated elevate VBN cord-002728-6oyw5sqv 177 6 in in IN cord-002728-6oyw5sqv 177 7 donor donor NN cord-002728-6oyw5sqv 177 8 lungs lung NNS cord-002728-6oyw5sqv 177 9 and and CC cord-002728-6oyw5sqv 177 10 show show VB cord-002728-6oyw5sqv 177 11 divergent divergent JJ cord-002728-6oyw5sqv 177 12 dynamics dynamic NNS cord-002728-6oyw5sqv 177 13 in in IN cord-002728-6oyw5sqv 177 14 primary primary JJ cord-002728-6oyw5sqv 177 15 graft graft NN cord-002728-6oyw5sqv 177 16 dysfunction dysfunction NN cord-002728-6oyw5sqv 177 17 Reagent reagent NN cord-002728-6oyw5sqv 177 18 and and CC cord-002728-6oyw5sqv 177 19 laboratory laboratory NN cord-002728-6oyw5sqv 177 20 contamination contamination NN cord-002728-6oyw5sqv 177 21 can can MD cord-002728-6oyw5sqv 177 22 critically critically RB cord-002728-6oyw5sqv 177 23 impact impact VB cord-002728-6oyw5sqv 177 24 sequence sequence NN cord-002728-6oyw5sqv 177 25 - - HYPH cord-002728-6oyw5sqv 177 26 based base VBN cord-002728-6oyw5sqv 177 27 microbiome microbiome NN cord-002728-6oyw5sqv 177 28 analyses analysis NNS cord-002728-6oyw5sqv 177 29 Direct direct VBP cord-002728-6oyw5sqv 177 30 multiplexed multiplexed JJ cord-002728-6oyw5sqv 177 31 whole whole JJ cord-002728-6oyw5sqv 177 32 genome genome NN cord-002728-6oyw5sqv 177 33 sequencing sequencing NN cord-002728-6oyw5sqv 177 34 of of IN cord-002728-6oyw5sqv 177 35 respiratory respiratory JJ cord-002728-6oyw5sqv 177 36 tract tract NN cord-002728-6oyw5sqv 177 37 samples sample NNS cord-002728-6oyw5sqv 177 38 reveals reveal VBZ cord-002728-6oyw5sqv 177 39 full full JJ cord-002728-6oyw5sqv 177 40 viral viral JJ cord-002728-6oyw5sqv 177 41 genomic genomic JJ cord-002728-6oyw5sqv 177 42 information information NN cord-002728-6oyw5sqv 177 43 Analysis Analysis NNP cord-002728-6oyw5sqv 177 44 of of IN cord-002728-6oyw5sqv 177 45 the the DT cord-002728-6oyw5sqv 177 46 virus virus NN cord-002728-6oyw5sqv 177 47 population population NN cord-002728-6oyw5sqv 177 48 present present JJ cord-002728-6oyw5sqv 177 49 in in IN cord-002728-6oyw5sqv 177 50 equine equine JJ cord-002728-6oyw5sqv 177 51 faeces faece NNS cord-002728-6oyw5sqv 177 52 indicates indicate VBZ cord-002728-6oyw5sqv 177 53 the the DT cord-002728-6oyw5sqv 177 54 presence presence NN cord-002728-6oyw5sqv 177 55 of of IN cord-002728-6oyw5sqv 177 56 hundreds hundred NNS cord-002728-6oyw5sqv 177 57 of of IN cord-002728-6oyw5sqv 177 58 uncharacterized uncharacterized JJ cord-002728-6oyw5sqv 177 59 virus virus NN cord-002728-6oyw5sqv 177 60 genomes genome NNS cord-002728-6oyw5sqv 177 61 The the DT cord-002728-6oyw5sqv 177 62 marine marine JJ cord-002728-6oyw5sqv 177 63 viromes virome NNS cord-002728-6oyw5sqv 177 64 of of IN cord-002728-6oyw5sqv 177 65 four four CD cord-002728-6oyw5sqv 177 66 oceanic oceanic JJ cord-002728-6oyw5sqv 177 67 regions region NNS cord-002728-6oyw5sqv 177 68 VirFinder VirFinder NNP cord-002728-6oyw5sqv 177 69 : : : cord-002728-6oyw5sqv 177 70 a a DT cord-002728-6oyw5sqv 177 71 novel novel JJ cord-002728-6oyw5sqv 177 72 kmer kmer NN cord-002728-6oyw5sqv 177 73 based base VBN cord-002728-6oyw5sqv 177 74 tool tool NN cord-002728-6oyw5sqv 177 75 for for IN cord-002728-6oyw5sqv 177 76 identifying identify VBG cord-002728-6oyw5sqv 177 77 viral viral JJ cord-002728-6oyw5sqv 177 78 sequences sequence NNS cord-002728-6oyw5sqv 177 79 from from IN cord-002728-6oyw5sqv 177 80 assembled assemble VBN cord-002728-6oyw5sqv 177 81 metagenomic metagenomic NNP cord-002728-6oyw5sqv 177 82 data data NNP cord-002728-6oyw5sqv 177 83 Alignment Alignment NNP cord-002728-6oyw5sqv 177 84 - - HYPH cord-002728-6oyw5sqv 177 85 free free JJ cord-002728-6oyw5sqv 177 86 d d NN cord-002728-6oyw5sqv 177 87 2 2 CD cord-002728-6oyw5sqv 178 1 * * NFP cord-002728-6oyw5sqv 178 2 oligonucleotide oligonucleotide JJ cord-002728-6oyw5sqv 178 3 frequency frequency NN cord-002728-6oyw5sqv 178 4 dissimilarity dissimilarity NN cord-002728-6oyw5sqv 178 5 measure measure NN cord-002728-6oyw5sqv 178 6 improves improve VBZ cord-002728-6oyw5sqv 178 7 prediction prediction NN cord-002728-6oyw5sqv 178 8 of of IN cord-002728-6oyw5sqv 178 9 hosts host NNS cord-002728-6oyw5sqv 178 10 from from IN cord-002728-6oyw5sqv 178 11 metagenomically metagenomically RB cord-002728-6oyw5sqv 178 12 - - HYPH cord-002728-6oyw5sqv 178 13 derived derive VBN cord-002728-6oyw5sqv 178 14 viral viral JJ cord-002728-6oyw5sqv 178 15 sequences sequence NNS cord-002728-6oyw5sqv 179 1 A a DT cord-002728-6oyw5sqv 179 2 roadmap roadmap NN cord-002728-6oyw5sqv 179 3 to to IN cord-002728-6oyw5sqv 179 4 the the DT cord-002728-6oyw5sqv 179 5 human human JJ cord-002728-6oyw5sqv 179 6 virome virome NNP cord-002728-6oyw5sqv 179 7 Human Human NNP cord-002728-6oyw5sqv 179 8 viruses virus NNS cord-002728-6oyw5sqv 179 9 : : : cord-002728-6oyw5sqv 179 10 discovery discovery NN cord-002728-6oyw5sqv 179 11 and and CC cord-002728-6oyw5sqv 179 12 emergence emergence NN cord-002728-6oyw5sqv 179 13 Prophage Prophage NNP cord-002728-6oyw5sqv 179 14 - - HYPH cord-002728-6oyw5sqv 179 15 like like JJ cord-002728-6oyw5sqv 180 1 gene gene NN cord-002728-6oyw5sqv 180 2 transfer transfer NN cord-002728-6oyw5sqv 180 3 agents agent NNS cord-002728-6oyw5sqv 180 4 - - HYPH cord-002728-6oyw5sqv 180 5 novel novel NN cord-002728-6oyw5sqv 180 6 mechanisms mechanism NNS cord-002728-6oyw5sqv 180 7 of of IN cord-002728-6oyw5sqv 180 8 gene gene NN cord-002728-6oyw5sqv 180 9 exchange exchange NN cord-002728-6oyw5sqv 180 10 for for IN cord-002728-6oyw5sqv 180 11 Methanococcus Methanococcus NNP cord-002728-6oyw5sqv 180 12 , , , cord-002728-6oyw5sqv 180 13 Desulfovibrio Desulfovibrio NNP cord-002728-6oyw5sqv 180 14 , , , cord-002728-6oyw5sqv 180 15 Brachyspira Brachyspira NNP cord-002728-6oyw5sqv 180 16 , , , cord-002728-6oyw5sqv 180 17 and and CC cord-002728-6oyw5sqv 180 18 Rhodobacter Rhodobacter NNP cord-002728-6oyw5sqv 180 19 species specie NNS cord-002728-6oyw5sqv 180 20 Transfer transfer NN cord-002728-6oyw5sqv 180 21 of of IN cord-002728-6oyw5sqv 180 22 antibiotic antibiotic JJ cord-002728-6oyw5sqv 180 23 - - HYPH cord-002728-6oyw5sqv 180 24 resistance resistance NN cord-002728-6oyw5sqv 180 25 genes gene NNS cord-002728-6oyw5sqv 180 26 via via IN cord-002728-6oyw5sqv 180 27 phage phage NN cord-002728-6oyw5sqv 180 28 - - HYPH cord-002728-6oyw5sqv 180 29 related relate VBN cord-002728-6oyw5sqv 180 30 mobile mobile JJ cord-002728-6oyw5sqv 180 31 elements element NNS cord-002728-6oyw5sqv 180 32 Exosome Exosome NNP cord-002728-6oyw5sqv 180 33 can can MD cord-002728-6oyw5sqv 180 34 prevent prevent VB cord-002728-6oyw5sqv 180 35 RNase rnase NN cord-002728-6oyw5sqv 180 36 from from IN cord-002728-6oyw5sqv 180 37 degrading degrade VBG cord-002728-6oyw5sqv 180 38 microRNA microRNA NNP cord-002728-6oyw5sqv 180 39 in in IN cord-002728-6oyw5sqv 180 40 feces fece NNS cord-002728-6oyw5sqv 181 1 Q&A Q&A NNP cord-002728-6oyw5sqv 181 2 : : : cord-002728-6oyw5sqv 182 1 What what WP cord-002728-6oyw5sqv 182 2 are be VBP cord-002728-6oyw5sqv 182 3 exosomes exosome NNS cord-002728-6oyw5sqv 182 4 , , , cord-002728-6oyw5sqv 182 5 exactly exactly RB cord-002728-6oyw5sqv 182 6 ? ? . cord-002728-6oyw5sqv 183 1 Membrane membrane NN cord-002728-6oyw5sqv 183 2 vesiclemediated vesiclemediated JJ cord-002728-6oyw5sqv 183 3 release release NN cord-002728-6oyw5sqv 183 4 of of IN cord-002728-6oyw5sqv 183 5 bacterial bacterial JJ cord-002728-6oyw5sqv 183 6 Klebsiella Klebsiella NNP cord-002728-6oyw5sqv 183 7 pneumoniae pneumoniae NN cord-002728-6oyw5sqv 183 8 subsp subsp NN cord-002728-6oyw5sqv 183 9 . . . cord-002728-6oyw5sqv 184 1 pneumoniae pneumoniae NN cord-002728-6oyw5sqv 184 2 - - HYPH cord-002728-6oyw5sqv 184 3 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 184 4 combination combination NN cord-002728-6oyw5sqv 184 5 from from IN cord-002728-6oyw5sqv 184 6 the the DT cord-002728-6oyw5sqv 184 7 caecal caecal JJ cord-002728-6oyw5sqv 184 8 effluent effluent NN cord-002728-6oyw5sqv 184 9 of of IN cord-002728-6oyw5sqv 184 10 a a DT cord-002728-6oyw5sqv 184 11 healthy healthy JJ cord-002728-6oyw5sqv 184 12 woman woman NN cord-002728-6oyw5sqv 185 1 Phage phage NN cord-002728-6oyw5sqv 185 2 tail tail NN cord-002728-6oyw5sqv 185 3 - - HYPH cord-002728-6oyw5sqv 185 4 like like JJ cord-002728-6oyw5sqv 185 5 particles particle NNS cord-002728-6oyw5sqv 185 6 kill kill VBP cord-002728-6oyw5sqv 185 7 Clostridium clostridium NN cord-002728-6oyw5sqv 185 8 difficile difficile NN cord-002728-6oyw5sqv 185 9 and and CC cord-002728-6oyw5sqv 185 10 represent represent VB cord-002728-6oyw5sqv 185 11 an an DT cord-002728-6oyw5sqv 185 12 alternative alternative NN cord-002728-6oyw5sqv 185 13 to to IN cord-002728-6oyw5sqv 185 14 conventional conventional JJ cord-002728-6oyw5sqv 185 15 antibiotics antibiotic NNS cord-002728-6oyw5sqv 185 16 Three three CD cord-002728-6oyw5sqv 185 17 new new JJ cord-002728-6oyw5sqv 185 18 Escherichia Escherichia NNP cord-002728-6oyw5sqv 185 19 coli coli NNS cord-002728-6oyw5sqv 185 20 phages phage NNS cord-002728-6oyw5sqv 185 21 from from IN cord-002728-6oyw5sqv 185 22 the the DT cord-002728-6oyw5sqv 185 23 human human JJ cord-002728-6oyw5sqv 185 24 gut gut NN cord-002728-6oyw5sqv 185 25 show show NN cord-002728-6oyw5sqv 185 26 promising promise VBG cord-002728-6oyw5sqv 185 27 potential potential NN cord-002728-6oyw5sqv 185 28 for for IN cord-002728-6oyw5sqv 185 29 phage phage NN cord-002728-6oyw5sqv 185 30 therapy therapy NN cord-002728-6oyw5sqv 185 31 Lytic lytic JJ cord-002728-6oyw5sqv 185 32 bacteriophage bacteriophage NN cord-002728-6oyw5sqv 185 33 PM16 PM16 NNP cord-002728-6oyw5sqv 185 34 specific specific JJ cord-002728-6oyw5sqv 185 35 for for IN cord-002728-6oyw5sqv 185 36 Proteus Proteus NNP cord-002728-6oyw5sqv 185 37 mirabilis mirabilis NNP cord-002728-6oyw5sqv 185 38 : : : cord-002728-6oyw5sqv 185 39 a a DT cord-002728-6oyw5sqv 185 40 novel novel JJ cord-002728-6oyw5sqv 185 41 member member NN cord-002728-6oyw5sqv 185 42 of of IN cord-002728-6oyw5sqv 185 43 the the DT cord-002728-6oyw5sqv 185 44 genus genus NN cord-002728-6oyw5sqv 185 45 Phikmvvirus Phikmvvirus NNP cord-002728-6oyw5sqv 185 46 Full Full NNP cord-002728-6oyw5sqv 185 47 genome genome NN cord-002728-6oyw5sqv 185 48 virus virus NN cord-002728-6oyw5sqv 185 49 detection detection NN cord-002728-6oyw5sqv 185 50 in in IN cord-002728-6oyw5sqv 185 51 fecal fecal JJ cord-002728-6oyw5sqv 185 52 samples sample NNS cord-002728-6oyw5sqv 185 53 using use VBG cord-002728-6oyw5sqv 185 54 sensitive sensitive JJ cord-002728-6oyw5sqv 185 55 nucleic nucleic JJ cord-002728-6oyw5sqv 185 56 acid acid NN cord-002728-6oyw5sqv 185 57 preparation preparation NN cord-002728-6oyw5sqv 185 58 , , , cord-002728-6oyw5sqv 185 59 deep deep JJ cord-002728-6oyw5sqv 185 60 sequencing sequencing NN cord-002728-6oyw5sqv 185 61 , , , cord-002728-6oyw5sqv 185 62 and and CC cord-002728-6oyw5sqv 185 63 a a DT cord-002728-6oyw5sqv 185 64 novel novel JJ cord-002728-6oyw5sqv 185 65 iterative iterative JJ cord-002728-6oyw5sqv 185 66 sequence sequence NN cord-002728-6oyw5sqv 185 67 classification classification NN cord-002728-6oyw5sqv 185 68 algorithm algorithm NN cord-002728-6oyw5sqv 185 69 Direct direct JJ cord-002728-6oyw5sqv 185 70 sequencing sequencing NN cord-002728-6oyw5sqv 185 71 of of IN cord-002728-6oyw5sqv 185 72 human human JJ cord-002728-6oyw5sqv 185 73 gut gut NN cord-002728-6oyw5sqv 185 74 virome virome NNP cord-002728-6oyw5sqv 185 75 fractions fraction NNS cord-002728-6oyw5sqv 185 76 obtained obtain VBN cord-002728-6oyw5sqv 185 77 by by IN cord-002728-6oyw5sqv 185 78 flow flow NN cord-002728-6oyw5sqv 185 79 cytometry cytometry NN cord-002728-6oyw5sqv 186 1 Comparing compare VBG cord-002728-6oyw5sqv 186 2 viral viral JJ cord-002728-6oyw5sqv 186 3 metagenomics metagenomic NNS cord-002728-6oyw5sqv 186 4 methods method NNS cord-002728-6oyw5sqv 186 5 using use VBG cord-002728-6oyw5sqv 186 6 a a DT cord-002728-6oyw5sqv 186 7 highly highly RB cord-002728-6oyw5sqv 186 8 multiplexed multiplexe VBN cord-002728-6oyw5sqv 186 9 human human JJ cord-002728-6oyw5sqv 186 10 viral viral JJ cord-002728-6oyw5sqv 186 11 pathogens pathogen NNS cord-002728-6oyw5sqv 186 12 reagent reagent JJ cord-002728-6oyw5sqv 186 13 PHACCS PHACCS NNP cord-002728-6oyw5sqv 186 14 , , , cord-002728-6oyw5sqv 186 15 an an DT cord-002728-6oyw5sqv 186 16 online online JJ cord-002728-6oyw5sqv 186 17 tool tool NN cord-002728-6oyw5sqv 186 18 for for IN cord-002728-6oyw5sqv 186 19 estimating estimate VBG cord-002728-6oyw5sqv 186 20 the the DT cord-002728-6oyw5sqv 186 21 structure structure NN cord-002728-6oyw5sqv 186 22 and and CC cord-002728-6oyw5sqv 186 23 diversity diversity NN cord-002728-6oyw5sqv 186 24 of of IN cord-002728-6oyw5sqv 186 25 uncultured uncultured JJ cord-002728-6oyw5sqv 186 26 viral viral JJ cord-002728-6oyw5sqv 186 27 communities community NNS cord-002728-6oyw5sqv 186 28 using use VBG cord-002728-6oyw5sqv 186 29 metagenomic metagenomic JJ cord-002728-6oyw5sqv 186 30 information information NN cord-002728-6oyw5sqv 186 31 ACLAME ACLAME NNP cord-002728-6oyw5sqv 186 32 : : : cord-002728-6oyw5sqv 187 1 a a DT cord-002728-6oyw5sqv 187 2 CLAssification classification NN cord-002728-6oyw5sqv 187 3 of of IN cord-002728-6oyw5sqv 187 4 Mobile mobile JJ cord-002728-6oyw5sqv 187 5 genetic genetic JJ cord-002728-6oyw5sqv 187 6 Elements Elements NNP cord-002728-6oyw5sqv 187 7 , , , cord-002728-6oyw5sqv 187 8 update update NN cord-002728-6oyw5sqv 187 9 2010 2010 CD cord-002728-6oyw5sqv 187 10 Metavir Metavir NNP cord-002728-6oyw5sqv 187 11 : : : cord-002728-6oyw5sqv 187 12 a a DT cord-002728-6oyw5sqv 187 13 web web NN cord-002728-6oyw5sqv 187 14 server server NN cord-002728-6oyw5sqv 187 15 dedicated dedicate VBN cord-002728-6oyw5sqv 187 16 to to IN cord-002728-6oyw5sqv 187 17 virome virome NNP cord-002728-6oyw5sqv 187 18 analysis analysis NN cord-002728-6oyw5sqv 188 1 Metavir Metavir NNP cord-002728-6oyw5sqv 188 2 2 2 CD cord-002728-6oyw5sqv 188 3 : : : cord-002728-6oyw5sqv 188 4 new new JJ cord-002728-6oyw5sqv 188 5 tools tool NNS cord-002728-6oyw5sqv 188 6 for for IN cord-002728-6oyw5sqv 188 7 viral viral JJ cord-002728-6oyw5sqv 188 8 metagenome metagenome NN cord-002728-6oyw5sqv 188 9 comparison comparison NN cord-002728-6oyw5sqv 188 10 and and CC cord-002728-6oyw5sqv 188 11 assembled assemble VBD cord-002728-6oyw5sqv 188 12 virome virome JJ cord-002728-6oyw5sqv 188 13 analysis analysis NN cord-002728-6oyw5sqv 188 14 VIROME VIROME NNP cord-002728-6oyw5sqv 188 15 : : : cord-002728-6oyw5sqv 188 16 a a DT cord-002728-6oyw5sqv 188 17 standard standard JJ cord-002728-6oyw5sqv 188 18 operating operating NN cord-002728-6oyw5sqv 188 19 procedure procedure NN cord-002728-6oyw5sqv 188 20 for for IN cord-002728-6oyw5sqv 188 21 analysis analysis NN cord-002728-6oyw5sqv 188 22 of of IN cord-002728-6oyw5sqv 188 23 viral viral JJ cord-002728-6oyw5sqv 188 24 metagenome metagenome NN cord-002728-6oyw5sqv 188 25 sequences sequence NNS cord-002728-6oyw5sqv 188 26 Molecular molecular JJ cord-002728-6oyw5sqv 188 27 methods method NNS cord-002728-6oyw5sqv 188 28 of of IN cord-002728-6oyw5sqv 188 29 virus virus NN cord-002728-6oyw5sqv 188 30 detection detection NN cord-002728-6oyw5sqv 188 31 in in IN cord-002728-6oyw5sqv 188 32 lymphoma lymphoma NN cord-002728-6oyw5sqv 188 33 VirSorter VirSorter NNP cord-002728-6oyw5sqv 188 34 : : : cord-002728-6oyw5sqv 189 1 mining mining NN cord-002728-6oyw5sqv 189 2 viral viral JJ cord-002728-6oyw5sqv 189 3 signal signal NN cord-002728-6oyw5sqv 189 4 from from IN cord-002728-6oyw5sqv 189 5 microbial microbial JJ cord-002728-6oyw5sqv 189 6 genomic genomic JJ cord-002728-6oyw5sqv 189 7 data datum NNS cord-002728-6oyw5sqv 189 8 ViromeScan ViromeScan NNP cord-002728-6oyw5sqv 189 9 : : : cord-002728-6oyw5sqv 189 10 a a DT cord-002728-6oyw5sqv 189 11 new new JJ cord-002728-6oyw5sqv 189 12 tool tool NN cord-002728-6oyw5sqv 189 13 for for IN cord-002728-6oyw5sqv 189 14 metagenomic metagenomic NNP cord-002728-6oyw5sqv 189 15 viral viral JJ cord-002728-6oyw5sqv 189 16 community community NN cord-002728-6oyw5sqv 189 17 profiling profile VBG cord-002728-6oyw5sqv 189 18 VIP vip NN cord-002728-6oyw5sqv 189 19 : : : cord-002728-6oyw5sqv 189 20 an an DT cord-002728-6oyw5sqv 189 21 integrated integrated JJ cord-002728-6oyw5sqv 189 22 pipeline pipeline NN cord-002728-6oyw5sqv 189 23 for for IN cord-002728-6oyw5sqv 189 24 metagenomics metagenomic NNS cord-002728-6oyw5sqv 189 25 of of IN cord-002728-6oyw5sqv 189 26 virus virus NN cord-002728-6oyw5sqv 189 27 identification identification NN cord-002728-6oyw5sqv 189 28 and and CC cord-002728-6oyw5sqv 189 29 discovery discovery NN cord-002728-6oyw5sqv 189 30 VirusDetect VirusDetect NNP cord-002728-6oyw5sqv 189 31 : : : cord-002728-6oyw5sqv 189 32 An an DT cord-002728-6oyw5sqv 189 33 automated automated JJ cord-002728-6oyw5sqv 189 34 pipeline pipeline NN cord-002728-6oyw5sqv 189 35 for for IN cord-002728-6oyw5sqv 189 36 efficient efficient JJ cord-002728-6oyw5sqv 189 37 virus virus NN cord-002728-6oyw5sqv 189 38 discovery discovery NN cord-002728-6oyw5sqv 189 39 using use VBG cord-002728-6oyw5sqv 189 40 deep deep JJ cord-002728-6oyw5sqv 189 41 sequencing sequencing NN cord-002728-6oyw5sqv 189 42 of of IN cord-002728-6oyw5sqv 189 43 small small JJ cord-002728-6oyw5sqv 189 44 RNAs rna NNS cord-002728-6oyw5sqv 189 45 PHASTER PHASTER NNP cord-002728-6oyw5sqv 189 46 : : : cord-002728-6oyw5sqv 189 47 a a DT cord-002728-6oyw5sqv 189 48 better well JJR cord-002728-6oyw5sqv 189 49 , , , cord-002728-6oyw5sqv 189 50 faster fast JJR cord-002728-6oyw5sqv 189 51 version version NN cord-002728-6oyw5sqv 189 52 of of IN cord-002728-6oyw5sqv 189 53 the the DT cord-002728-6oyw5sqv 189 54 PHAST PHAST NNP cord-002728-6oyw5sqv 189 55 phage phage NN cord-002728-6oyw5sqv 189 56 search search NN cord-002728-6oyw5sqv 189 57 tool tool NN cord-002728-6oyw5sqv 189 58 VirusSeeker VirusSeeker NNP cord-002728-6oyw5sqv 189 59 , , , cord-002728-6oyw5sqv 189 60 a a DT cord-002728-6oyw5sqv 189 61 computational computational JJ cord-002728-6oyw5sqv 189 62 pipeline pipeline NN cord-002728-6oyw5sqv 189 63 for for IN cord-002728-6oyw5sqv 189 64 virus virus NN cord-002728-6oyw5sqv 189 65 discovery discovery NN cord-002728-6oyw5sqv 189 66 and and CC cord-002728-6oyw5sqv 190 1 virome virome NNP cord-002728-6oyw5sqv 190 2 composition composition NN cord-002728-6oyw5sqv 190 3 analysis analysis NN cord-002728-6oyw5sqv 191 1 Defining define VBG cord-002728-6oyw5sqv 191 2 dysbiosis dysbiosis NN cord-002728-6oyw5sqv 191 3 and and CC cord-002728-6oyw5sqv 191 4 its -PRON- PRP$ cord-002728-6oyw5sqv 191 5 influence influence NN cord-002728-6oyw5sqv 191 6 on on IN cord-002728-6oyw5sqv 191 7 host host NN cord-002728-6oyw5sqv 191 8 immunity immunity NN cord-002728-6oyw5sqv 191 9 and and CC cord-002728-6oyw5sqv 191 10 disease disease NN cord-002728-6oyw5sqv 191 11 Dysbiosis Dysbiosis NNP cord-002728-6oyw5sqv 191 12 in in IN cord-002728-6oyw5sqv 191 13 inflammatory inflammatory JJ cord-002728-6oyw5sqv 191 14 bowel bowel NN cord-002728-6oyw5sqv 191 15 disease disease NN cord-002728-6oyw5sqv 191 16 Microbiota Microbiota NNP cord-002728-6oyw5sqv 191 17 and and CC cord-002728-6oyw5sqv 191 18 neurological neurological JJ cord-002728-6oyw5sqv 191 19 disorders disorder NNS cord-002728-6oyw5sqv 191 20 : : : cord-002728-6oyw5sqv 191 21 a a DT cord-002728-6oyw5sqv 191 22 gut gut NN cord-002728-6oyw5sqv 191 23 feeling feeling NN