id sid tid token lemma pos cord-016364-80l5mua2 1 1 key key NN cord-016364-80l5mua2 1 2 : : : cord-016364-80l5mua2 2 1 cord-016364 cord-016364 NNP cord-016364-80l5mua2 2 2 - - HYPH cord-016364-80l5mua2 2 3 80l5mua2 80l5mua2 CD cord-016364-80l5mua2 2 4 authors author NNS cord-016364-80l5mua2 2 5 : : : cord-016364-80l5mua2 2 6 Menotti Menotti NNP cord-016364-80l5mua2 2 7 - - HYPH cord-016364-80l5mua2 2 8 Raymond Raymond NNP cord-016364-80l5mua2 2 9 , , , cord-016364-80l5mua2 2 10 Marilyn Marilyn NNP cord-016364-80l5mua2 2 11 ; ; : cord-016364-80l5mua2 2 12 O’Brien O’Brien NNP cord-016364-80l5mua2 2 13 , , , cord-016364-80l5mua2 2 14 Stephen Stephen NNP cord-016364-80l5mua2 2 15 J. J. NNP cord-016364-80l5mua2 3 1 title title NN cord-016364-80l5mua2 3 2 : : : cord-016364-80l5mua2 4 1 The the DT cord-016364-80l5mua2 4 2 Domestic Domestic NNP cord-016364-80l5mua2 4 3 Cat Cat NNP cord-016364-80l5mua2 4 4 , , , cord-016364-80l5mua2 4 5 Felis Felis NNP cord-016364-80l5mua2 4 6 catus catus NN cord-016364-80l5mua2 4 7 , , , cord-016364-80l5mua2 4 8 as as IN cord-016364-80l5mua2 4 9 a a DT cord-016364-80l5mua2 4 10 Model Model NNP cord-016364-80l5mua2 4 11 of of IN cord-016364-80l5mua2 4 12 Hereditary Hereditary NNP cord-016364-80l5mua2 4 13 and and CC cord-016364-80l5mua2 4 14 Infectious Infectious NNP cord-016364-80l5mua2 4 15 Disease Disease NNP cord-016364-80l5mua2 4 16 date date NN cord-016364-80l5mua2 4 17 : : : cord-016364-80l5mua2 4 18 2008 2008 CD cord-016364-80l5mua2 4 19 journal journal NN cord-016364-80l5mua2 4 20 : : : cord-016364-80l5mua2 4 21 Sourcebook Sourcebook NNP cord-016364-80l5mua2 4 22 of of IN cord-016364-80l5mua2 4 23 Models Models NNPS cord-016364-80l5mua2 4 24 for for IN cord-016364-80l5mua2 4 25 Biomedical Biomedical NNP cord-016364-80l5mua2 4 26 Research Research NNP cord-016364-80l5mua2 4 27 DOI DOI NNP cord-016364-80l5mua2 4 28 : : : cord-016364-80l5mua2 5 1 10.1007/978 10.1007/978 LS cord-016364-80l5mua2 5 2 - - HYPH cord-016364-80l5mua2 5 3 1 1 CD cord-016364-80l5mua2 5 4 - - HYPH cord-016364-80l5mua2 5 5 59745 59745 CD cord-016364-80l5mua2 5 6 - - HYPH cord-016364-80l5mua2 5 7 285 285 CD cord-016364-80l5mua2 5 8 - - HYPH cord-016364-80l5mua2 5 9 4_25 4_25 CD cord-016364-80l5mua2 5 10 sha sha NNP cord-016364-80l5mua2 5 11 : : : cord-016364-80l5mua2 5 12 76b09383740476d96a3e63ae0f265e2897e9a194 76b09383740476d96a3e63ae0f265e2897e9a194 CD cord-016364-80l5mua2 5 13 doc_id doc_id CD cord-016364-80l5mua2 5 14 : : : cord-016364-80l5mua2 5 15 16364 16364 CD cord-016364-80l5mua2 5 16 cord_uid cord_uid NNS cord-016364-80l5mua2 5 17 : : : cord-016364-80l5mua2 5 18 80l5mua2 80l5mua2 NNP cord-016364-80l5mua2 6 1 The the DT cord-016364-80l5mua2 6 2 domestic domestic JJ cord-016364-80l5mua2 6 3 cat cat NN cord-016364-80l5mua2 6 4 , , , cord-016364-80l5mua2 6 5 currently currently RB cord-016364-80l5mua2 6 6 the the DT cord-016364-80l5mua2 6 7 most most RBS cord-016364-80l5mua2 6 8 frequent frequent JJ cord-016364-80l5mua2 6 9 of of IN cord-016364-80l5mua2 6 10 companion companion NN cord-016364-80l5mua2 6 11 animals animal NNS cord-016364-80l5mua2 6 12 , , , cord-016364-80l5mua2 6 13 has have VBZ cord-016364-80l5mua2 6 14 enjoyed enjoy VBN cord-016364-80l5mua2 6 15 a a DT cord-016364-80l5mua2 6 16 medical medical JJ cord-016364-80l5mua2 6 17 surveillance surveillance NN cord-016364-80l5mua2 6 18 , , , cord-016364-80l5mua2 6 19 as as IN cord-016364-80l5mua2 6 20 a a DT cord-016364-80l5mua2 6 21 nonprimate nonprimate NN cord-016364-80l5mua2 6 22 species species NN cord-016364-80l5mua2 6 23 , , , cord-016364-80l5mua2 6 24 second second JJ cord-016364-80l5mua2 6 25 only only RB cord-016364-80l5mua2 6 26 to to IN cord-016364-80l5mua2 6 27 the the DT cord-016364-80l5mua2 6 28 dog dog NN cord-016364-80l5mua2 6 29 . . . cord-016364-80l5mua2 7 1 With with IN cord-016364-80l5mua2 7 2 over over IN cord-016364-80l5mua2 7 3 200 200 CD cord-016364-80l5mua2 7 4 hereditary hereditary JJ cord-016364-80l5mua2 7 5 disease disease NN cord-016364-80l5mua2 7 6 pathologies pathology NNS cord-016364-80l5mua2 7 7 reported report VBN cord-016364-80l5mua2 7 8 in in IN cord-016364-80l5mua2 7 9 the the DT cord-016364-80l5mua2 7 10 cat cat NN cord-016364-80l5mua2 7 11 , , , cord-016364-80l5mua2 7 12 the the DT cord-016364-80l5mua2 7 13 clinical clinical JJ cord-016364-80l5mua2 7 14 and and CC cord-016364-80l5mua2 7 15 physiological physiological JJ cord-016364-80l5mua2 7 16 study study NN cord-016364-80l5mua2 7 17 of of IN cord-016364-80l5mua2 7 18 these these DT cord-016364-80l5mua2 7 19 feline feline JJ cord-016364-80l5mua2 7 20 hereditary hereditary JJ cord-016364-80l5mua2 7 21 diseases disease NNS cord-016364-80l5mua2 7 22 provides provide VBZ cord-016364-80l5mua2 7 23 a a DT cord-016364-80l5mua2 7 24 strong strong JJ cord-016364-80l5mua2 7 25 comparative comparative JJ cord-016364-80l5mua2 7 26 medicine medicine NN cord-016364-80l5mua2 7 27 opportunity opportunity NN cord-016364-80l5mua2 7 28 for for IN cord-016364-80l5mua2 7 29 prevention prevention NN cord-016364-80l5mua2 7 30 , , , cord-016364-80l5mua2 7 31 diagnostics diagnostic NNS cord-016364-80l5mua2 7 32 , , , cord-016364-80l5mua2 7 33 and and CC cord-016364-80l5mua2 7 34 treatment treatment NN cord-016364-80l5mua2 7 35 studies study NNS cord-016364-80l5mua2 7 36 in in IN cord-016364-80l5mua2 7 37 a a DT cord-016364-80l5mua2 7 38 laboratory laboratory NN cord-016364-80l5mua2 7 39 setting setting NN cord-016364-80l5mua2 7 40 . . . cord-016364-80l5mua2 8 1 Causal causal NN cord-016364-80l5mua2 8 2 mutations mutation NNS cord-016364-80l5mua2 8 3 have have VBP cord-016364-80l5mua2 8 4 been be VBN cord-016364-80l5mua2 8 5 characterized characterize VBN cord-016364-80l5mua2 8 6 in in IN cord-016364-80l5mua2 8 7 19 19 CD cord-016364-80l5mua2 8 8 felid felid JJ cord-016364-80l5mua2 8 9 genes gene NNS cord-016364-80l5mua2 8 10 , , , cord-016364-80l5mua2 8 11 with with IN cord-016364-80l5mua2 8 12 the the DT cord-016364-80l5mua2 8 13 largest large JJS cord-016364-80l5mua2 8 14 representation representation NN cord-016364-80l5mua2 8 15 from from IN cord-016364-80l5mua2 8 16 lysosomal lysosomal JJ cord-016364-80l5mua2 8 17 storage storage NN cord-016364-80l5mua2 8 18 enzyme enzyme NN cord-016364-80l5mua2 8 19 disorders disorder NNS cord-016364-80l5mua2 8 20 . . . cord-016364-80l5mua2 9 1 Corrective corrective JJ cord-016364-80l5mua2 9 2 therapeutic therapeutic JJ cord-016364-80l5mua2 9 3 strategies strategy NNS cord-016364-80l5mua2 9 4 for for IN cord-016364-80l5mua2 9 5 several several JJ cord-016364-80l5mua2 9 6 disorders disorder NNS cord-016364-80l5mua2 9 7 have have VBP cord-016364-80l5mua2 9 8 been be VBN cord-016364-80l5mua2 9 9 proposed propose VBN cord-016364-80l5mua2 9 10 and and CC cord-016364-80l5mua2 9 11 examined examine VBN cord-016364-80l5mua2 9 12 in in IN cord-016364-80l5mua2 9 13 the the DT cord-016364-80l5mua2 9 14 cat cat NN cord-016364-80l5mua2 9 15 , , , cord-016364-80l5mua2 9 16 including include VBG cord-016364-80l5mua2 9 17 enzyme enzyme NN cord-016364-80l5mua2 9 18 replacement replacement NN cord-016364-80l5mua2 9 19 , , , cord-016364-80l5mua2 9 20 heterologous heterologous JJ cord-016364-80l5mua2 9 21 bone bone NN cord-016364-80l5mua2 9 22 marrow marrow NN cord-016364-80l5mua2 9 23 transplantation transplantation NN cord-016364-80l5mua2 9 24 , , , cord-016364-80l5mua2 9 25 and and CC cord-016364-80l5mua2 9 26 substrate substrate NN cord-016364-80l5mua2 9 27 reduction reduction NN cord-016364-80l5mua2 9 28 therapy therapy NN cord-016364-80l5mua2 9 29 . . . cord-016364-80l5mua2 10 1 Genomics genomic NNS cord-016364-80l5mua2 10 2 tools tool NNS cord-016364-80l5mua2 10 3 developed develop VBN cord-016364-80l5mua2 10 4 in in IN cord-016364-80l5mua2 10 5 the the DT cord-016364-80l5mua2 10 6 cat cat NN cord-016364-80l5mua2 10 7 , , , cord-016364-80l5mua2 10 8 including include VBG cord-016364-80l5mua2 10 9 the the DT cord-016364-80l5mua2 10 10 recent recent JJ cord-016364-80l5mua2 10 11 completion completion NN cord-016364-80l5mua2 10 12 of of IN cord-016364-80l5mua2 10 13 the the DT cord-016364-80l5mua2 10 14 2-fold 2-fold CD cord-016364-80l5mua2 10 15 whole whole JJ cord-016364-80l5mua2 10 16 genome genome NN cord-016364-80l5mua2 10 17 sequence sequence NN cord-016364-80l5mua2 10 18 of of IN cord-016364-80l5mua2 10 19 the the DT cord-016364-80l5mua2 10 20 cat cat NN cord-016364-80l5mua2 10 21 and and CC cord-016364-80l5mua2 10 22 genome genome NN cord-016364-80l5mua2 10 23 browser browser NN cord-016364-80l5mua2 10 24 , , , cord-016364-80l5mua2 10 25 radiation radiation NN cord-016364-80l5mua2 10 26 hybrid hybrid NN cord-016364-80l5mua2 10 27 map map NN cord-016364-80l5mua2 10 28 of of IN cord-016364-80l5mua2 10 29 1793 1793 CD cord-016364-80l5mua2 10 30 integrated integrated JJ cord-016364-80l5mua2 10 31 coding coding NN cord-016364-80l5mua2 10 32 and and CC cord-016364-80l5mua2 10 33 microsatellite microsatellite JJ cord-016364-80l5mua2 10 34 loci locus NNS cord-016364-80l5mua2 10 35 , , , cord-016364-80l5mua2 10 36 a a DT cord-016364-80l5mua2 10 37 5-cM 5-cm CD cord-016364-80l5mua2 10 38 genetic genetic JJ cord-016364-80l5mua2 10 39 linkage linkage NN cord-016364-80l5mua2 10 40 map map NN cord-016364-80l5mua2 10 41 , , , cord-016364-80l5mua2 10 42 arrayed array VBD cord-016364-80l5mua2 10 43 BAC BAC NNP cord-016364-80l5mua2 10 44 libraries library NNS cord-016364-80l5mua2 10 45 , , , cord-016364-80l5mua2 10 46 and and CC cord-016364-80l5mua2 10 47 flow flow VB cord-016364-80l5mua2 10 48 sorted sorted JJ cord-016364-80l5mua2 10 49 chromosomes chromosome NNS cord-016364-80l5mua2 10 50 , , , cord-016364-80l5mua2 10 51 are be VBP cord-016364-80l5mua2 10 52 providing provide VBG cord-016364-80l5mua2 10 53 resources resource NNS cord-016364-80l5mua2 10 54 that that WDT cord-016364-80l5mua2 10 55 are be VBP cord-016364-80l5mua2 10 56 being be VBG cord-016364-80l5mua2 10 57 utilized utilize VBN cord-016364-80l5mua2 10 58 in in IN cord-016364-80l5mua2 10 59 mapping mapping NN cord-016364-80l5mua2 10 60 and and CC cord-016364-80l5mua2 10 61 characterization characterization NN cord-016364-80l5mua2 10 62 of of IN cord-016364-80l5mua2 10 63 genes gene NNS cord-016364-80l5mua2 10 64 of of IN cord-016364-80l5mua2 10 65 interest interest NN cord-016364-80l5mua2 10 66 . . . cord-016364-80l5mua2 11 1 A a DT cord-016364-80l5mua2 11 2 recent recent JJ cord-016364-80l5mua2 11 3 report report NN cord-016364-80l5mua2 11 4 of of IN cord-016364-80l5mua2 11 5 the the DT cord-016364-80l5mua2 11 6 mapping mapping NN cord-016364-80l5mua2 11 7 and and CC cord-016364-80l5mua2 11 8 characterization characterization NN cord-016364-80l5mua2 11 9 of of IN cord-016364-80l5mua2 11 10 a a DT cord-016364-80l5mua2 11 11 novel novel JJ cord-016364-80l5mua2 11 12 causative causative JJ cord-016364-80l5mua2 11 13 gene gene NN cord-016364-80l5mua2 11 14 for for IN cord-016364-80l5mua2 11 15 feline feline JJ cord-016364-80l5mua2 11 16 spinal spinal JJ cord-016364-80l5mua2 11 17 muscular muscular JJ cord-016364-80l5mua2 11 18 atrophy atrophy NN cord-016364-80l5mua2 11 19 marked mark VBD cord-016364-80l5mua2 11 20 the the DT cord-016364-80l5mua2 11 21 first first JJ cord-016364-80l5mua2 11 22 identification identification NN cord-016364-80l5mua2 11 23 of of IN cord-016364-80l5mua2 11 24 a a DT cord-016364-80l5mua2 11 25 disease disease NN cord-016364-80l5mua2 11 26 gene gene NN cord-016364-80l5mua2 11 27 purely purely RB cord-016364-80l5mua2 11 28 from from IN cord-016364-80l5mua2 11 29 positional positional JJ cord-016364-80l5mua2 11 30 reasoning reasoning NN cord-016364-80l5mua2 11 31 . . . cord-016364-80l5mua2 12 1 With with IN cord-016364-80l5mua2 12 2 the the DT cord-016364-80l5mua2 12 3 development development NN cord-016364-80l5mua2 12 4 of of IN cord-016364-80l5mua2 12 5 genomic genomic JJ cord-016364-80l5mua2 12 6 resources resource NNS cord-016364-80l5mua2 12 7 in in IN cord-016364-80l5mua2 12 8 the the DT cord-016364-80l5mua2 12 9 cat cat NN cord-016364-80l5mua2 12 10 and and CC cord-016364-80l5mua2 12 11 the the DT cord-016364-80l5mua2 12 12 application application NN cord-016364-80l5mua2 12 13 of of IN cord-016364-80l5mua2 12 14 complementary complementary JJ cord-016364-80l5mua2 12 15 comparative comparative JJ cord-016364-80l5mua2 12 16 tools tool NNS cord-016364-80l5mua2 12 17 developed develop VBN cord-016364-80l5mua2 12 18 in in IN cord-016364-80l5mua2 12 19 other other JJ cord-016364-80l5mua2 12 20 species specie NNS cord-016364-80l5mua2 12 21 , , , cord-016364-80l5mua2 12 22 the the DT cord-016364-80l5mua2 12 23 domestic domestic JJ cord-016364-80l5mua2 12 24 cat cat NN cord-016364-80l5mua2 12 25 is be VBZ cord-016364-80l5mua2 12 26 emerging emerge VBG cord-016364-80l5mua2 12 27 as as IN cord-016364-80l5mua2 12 28 a a DT cord-016364-80l5mua2 12 29 promising promising JJ cord-016364-80l5mua2 12 30 resource resource NN cord-016364-80l5mua2 12 31 of of IN cord-016364-80l5mua2 12 32 phenotypically phenotypically RB cord-016364-80l5mua2 12 33 defined define VBN cord-016364-80l5mua2 12 34 genetic genetic JJ cord-016364-80l5mua2 12 35 variation variation NN cord-016364-80l5mua2 12 36 of of IN cord-016364-80l5mua2 12 37 biomedical biomedical JJ cord-016364-80l5mua2 12 38 significance significance NN cord-016364-80l5mua2 12 39 . . . cord-016364-80l5mua2 13 1 Additionally additionally RB cord-016364-80l5mua2 13 2 , , , cord-016364-80l5mua2 13 3 the the DT cord-016364-80l5mua2 13 4 cat cat NN cord-016364-80l5mua2 13 5 has have VBZ cord-016364-80l5mua2 13 6 provided provide VBN cord-016364-80l5mua2 13 7 several several JJ cord-016364-80l5mua2 13 8 useful useful JJ cord-016364-80l5mua2 13 9 models model NNS cord-016364-80l5mua2 13 10 for for IN cord-016364-80l5mua2 13 11 infectious infectious JJ cord-016364-80l5mua2 13 12 disease disease NN cord-016364-80l5mua2 13 13 . . . cord-016364-80l5mua2 14 1 These these DT cord-016364-80l5mua2 14 2 include include VBP cord-016364-80l5mua2 14 3 feline feline JJ cord-016364-80l5mua2 14 4 leukemia leukemia NN cord-016364-80l5mua2 14 5 and and CC cord-016364-80l5mua2 14 6 feline feline JJ cord-016364-80l5mua2 14 7 sarcoma sarcoma NN cord-016364-80l5mua2 14 8 virus virus NN cord-016364-80l5mua2 14 9 , , , cord-016364-80l5mua2 14 10 feline feline JJ cord-016364-80l5mua2 14 11 coronavirus coronavirus NN cord-016364-80l5mua2 14 12 , , , cord-016364-80l5mua2 14 13 and and CC cord-016364-80l5mua2 14 14 Type type NN cord-016364-80l5mua2 14 15 C c NN cord-016364-80l5mua2 14 16 retroviruses retrovirus NNS cord-016364-80l5mua2 14 17 that that WDT cord-016364-80l5mua2 14 18 interact interact VBP cord-016364-80l5mua2 14 19 with with IN cord-016364-80l5mua2 14 20 cellular cellular JJ cord-016364-80l5mua2 14 21 oncogenes oncogene NNS cord-016364-80l5mua2 14 22 to to TO cord-016364-80l5mua2 14 23 induce induce VB cord-016364-80l5mua2 14 24 leukemia leukemia NN cord-016364-80l5mua2 14 25 , , , cord-016364-80l5mua2 14 26 lymphoma lymphoma NN cord-016364-80l5mua2 14 27 , , , cord-016364-80l5mua2 14 28 and and CC cord-016364-80l5mua2 14 29 sarcoma sarcoma NN cord-016364-80l5mua2 14 30 . . . cord-016364-80l5mua2 15 1 Mankind mankind NN cord-016364-80l5mua2 15 2 has have VBZ cord-016364-80l5mua2 15 3 held hold VBN cord-016364-80l5mua2 15 4 a a DT cord-016364-80l5mua2 15 5 centuries century NNS cord-016364-80l5mua2 15 6 - - HYPH cord-016364-80l5mua2 15 7 long long JJ cord-016364-80l5mua2 15 8 fascination fascination NN cord-016364-80l5mua2 15 9 with with IN cord-016364-80l5mua2 15 10 the the DT cord-016364-80l5mua2 15 11 cat cat NN cord-016364-80l5mua2 15 12 . . . cord-016364-80l5mua2 16 1 The the DT cord-016364-80l5mua2 16 2 earliest early JJS cord-016364-80l5mua2 16 3 arch arch JJ cord-016364-80l5mua2 16 4 eological eological JJ cord-016364-80l5mua2 16 5 records record NNS cord-016364-80l5mua2 16 6 that that WDT cord-016364-80l5mua2 16 7 have have VBP cord-016364-80l5mua2 16 8 been be VBN cord-016364-80l5mua2 16 9 linked link VBN cord-016364-80l5mua2 16 10 to to IN cord-016364-80l5mua2 16 11 the the DT cord-016364-80l5mua2 16 12 domestication domestication NN cord-016364-80l5mua2 16 13 of of IN cord-016364-80l5mua2 16 14 Felis Felis NNP cord-016364-80l5mua2 16 15 catus catus NN cord-016364-80l5mua2 16 16 date date NN cord-016364-80l5mua2 16 17 to to IN cord-016364-80l5mua2 16 18 approximately approximately RB cord-016364-80l5mua2 16 19 9500 9500 CD cord-016364-80l5mua2 16 20 years year NNS cord-016364-80l5mua2 16 21 ago ago RB cord-016364-80l5mua2 16 22 from from IN cord-016364-80l5mua2 16 23 Cyprus Cyprus NNP cord-016364-80l5mua2 16 24 , , , cord-016364-80l5mua2 16 25 1 1 CD cord-016364-80l5mua2 16 26 with with IN cord-016364-80l5mua2 16 27 recent recent JJ cord-016364-80l5mua2 16 28 molecular molecular JJ cord-016364-80l5mua2 16 29 genetic genetic JJ cord-016364-80l5mua2 16 30 analyses analysis NNS cord-016364-80l5mua2 16 31 in in IN cord-016364-80l5mua2 16 32 our -PRON- PRP$ cord-016364-80l5mua2 16 33 laboratory laboratory NN cord-016364-80l5mua2 16 34 suggesting suggest VBG cord-016364-80l5mua2 16 35 a a DT cord-016364-80l5mua2 16 36 Middle middle JJ cord-016364-80l5mua2 16 37 Eastern eastern JJ cord-016364-80l5mua2 16 38 origin origin NN cord-016364-80l5mua2 16 39 for for IN cord-016364-80l5mua2 16 40 domestication domestication NN cord-016364-80l5mua2 17 1 ( ( -LRB- cord-016364-80l5mua2 17 2 C. C. NNP cord-016364-80l5mua2 17 3 Driscoll Driscoll NNP cord-016364-80l5mua2 17 4 et et NNP cord-016364-80l5mua2 17 5 al al NNP cord-016364-80l5mua2 17 6 . . NNP cord-016364-80l5mua2 17 7 , , , cord-016364-80l5mua2 17 8 unpublished unpublished JJ cord-016364-80l5mua2 17 9 observations observation NNS cord-016364-80l5mua2 17 10 ) ) -RRB- cord-016364-80l5mua2 17 11 . . . cord-016364-80l5mua2 18 1 Currently currently RB cord-016364-80l5mua2 18 2 the the DT cord-016364-80l5mua2 18 3 most most RBS cord-016364-80l5mua2 18 4 numerous numerous JJ cord-016364-80l5mua2 18 5 of of IN cord-016364-80l5mua2 18 6 companion companion NN cord-016364-80l5mua2 18 7 animals animal NNS cord-016364-80l5mua2 18 8 , , , cord-016364-80l5mua2 18 9 numbering number VBG cord-016364-80l5mua2 18 10 close close RB cord-016364-80l5mua2 18 11 to to IN cord-016364-80l5mua2 18 12 90 90 CD cord-016364-80l5mua2 18 13 million million CD cord-016364-80l5mua2 18 14 in in IN cord-016364-80l5mua2 18 15 households household NNS cord-016364-80l5mua2 18 16 across across IN cord-016364-80l5mua2 18 17 the the DT cord-016364-80l5mua2 18 18 United United NNP cord-016364-80l5mua2 18 19 States States NNP cord-016364-80l5mua2 18 20 ( ( -LRB- cord-016364-80l5mua2 18 21 http://www.appma.org/ http://www.appma.org/ NNP cord-016364-80l5mua2 18 22 press_industrytrends.asp press_industrytrends.asp NNS cord-016364-80l5mua2 18 23 ) ) -RRB- cord-016364-80l5mua2 18 24 , , , cord-016364-80l5mua2 18 25 the the DT cord-016364-80l5mua2 18 26 cat cat NN cord-016364-80l5mua2 18 27 enjoys enjoy VBZ cord-016364-80l5mua2 18 28 a a DT cord-016364-80l5mua2 18 29 medical medical JJ cord-016364-80l5mua2 18 30 surveillance surveillance NN cord-016364-80l5mua2 18 31 second second RB cord-016364-80l5mua2 18 32 only only RB cord-016364-80l5mua2 18 33 to to IN cord-016364-80l5mua2 18 34 the the DT cord-016364-80l5mua2 18 35 dog dog NN cord-016364-80l5mua2 18 36 and and CC cord-016364-80l5mua2 18 37 humankind humankind NN cord-016364-80l5mua2 18 38 . . . cord-016364-80l5mua2 19 1 In in IN cord-016364-80l5mua2 19 2 this this DT cord-016364-80l5mua2 19 3 chapter chapter NN cord-016364-80l5mua2 19 4 we -PRON- PRP cord-016364-80l5mua2 19 5 review review VBP cord-016364-80l5mua2 19 6 the the DT cord-016364-80l5mua2 19 7 promise promise NN cord-016364-80l5mua2 19 8 of of IN cord-016364-80l5mua2 19 9 the the DT cord-016364-80l5mua2 19 10 cat cat NN cord-016364-80l5mua2 19 11 as as IN cord-016364-80l5mua2 19 12 an an DT cord-016364-80l5mua2 19 13 important important JJ cord-016364-80l5mua2 19 14 model model NN cord-016364-80l5mua2 19 15 for for IN cord-016364-80l5mua2 19 16 the the DT cord-016364-80l5mua2 19 17 advancement advancement NN cord-016364-80l5mua2 19 18 of of IN cord-016364-80l5mua2 19 19 human human JJ cord-016364-80l5mua2 19 20 hereditary hereditary JJ cord-016364-80l5mua2 19 21 and and CC cord-016364-80l5mua2 19 22 infectious infectious JJ cord-016364-80l5mua2 19 23 disease disease NN cord-016364-80l5mua2 19 24 and and CC cord-016364-80l5mua2 19 25 the the DT cord-016364-80l5mua2 19 26 genomic genomic JJ cord-016364-80l5mua2 19 27 tools tool NNS cord-016364-80l5mua2 19 28 that that WDT cord-016364-80l5mua2 19 29 have have VBP cord-016364-80l5mua2 19 30 been be VBN cord-016364-80l5mua2 19 31 developed develop VBN cord-016364-80l5mua2 19 32 for for IN cord-016364-80l5mua2 19 33 the the DT cord-016364-80l5mua2 19 34 identification identification NN cord-016364-80l5mua2 19 35 , , , cord-016364-80l5mua2 19 36 and and CC cord-016364-80l5mua2 19 37 characterization characterization NN cord-016364-80l5mua2 19 38 of of IN cord-016364-80l5mua2 19 39 genes gene NNS cord-016364-80l5mua2 19 40 of of IN cord-016364-80l5mua2 19 41 interest interest NN cord-016364-80l5mua2 19 42 . . . cord-016364-80l5mua2 20 1 For for IN cord-016364-80l5mua2 20 2 many many JJ cord-016364-80l5mua2 20 3 years year NNS cord-016364-80l5mua2 20 4 we -PRON- PRP cord-016364-80l5mua2 20 5 have have VBP cord-016364-80l5mua2 20 6 sought seek VBN cord-016364-80l5mua2 20 7 to to TO cord-016364-80l5mua2 20 8 characterize characterize VB cord-016364-80l5mua2 20 9 genetic genetic JJ cord-016364-80l5mua2 20 10 organization organization NN cord-016364-80l5mua2 20 11 in in IN cord-016364-80l5mua2 20 12 the the DT cord-016364-80l5mua2 20 13 domestic domestic JJ cord-016364-80l5mua2 20 14 cat cat NN cord-016364-80l5mua2 20 15 and and CC cord-016364-80l5mua2 20 16 to to TO cord-016364-80l5mua2 20 17 develop develop VB cord-016364-80l5mua2 20 18 genomic genomic JJ cord-016364-80l5mua2 20 19 resources resource NNS cord-016364-80l5mua2 20 20 that that WDT cord-016364-80l5mua2 20 21 establish establish VBP cord-016364-80l5mua2 20 22 F. F. NNP cord-016364-80l5mua2 20 23 catus catus NN cord-016364-80l5mua2 20 24 as as IN cord-016364-80l5mua2 20 25 a a DT cord-016364-80l5mua2 20 26 useful useful JJ cord-016364-80l5mua2 20 27 animal animal NN cord-016364-80l5mua2 20 28 model model NN cord-016364-80l5mua2 20 29 for for IN cord-016364-80l5mua2 20 30 human human JJ cord-016364-80l5mua2 20 31 hereditary hereditary JJ cord-016364-80l5mua2 20 32 disease disease NN cord-016364-80l5mua2 20 33 analogues analogue NNS cord-016364-80l5mua2 20 34 , , , cord-016364-80l5mua2 20 35 neoplasia neoplasia NN cord-016364-80l5mua2 20 36 , , , cord-016364-80l5mua2 20 37 genetic genetic JJ cord-016364-80l5mua2 20 38 factors factor NNS cord-016364-80l5mua2 20 39 associated associate VBN cord-016364-80l5mua2 20 40 with with IN cord-016364-80l5mua2 20 41 host host NN cord-016364-80l5mua2 20 42 response response NN cord-016364-80l5mua2 20 43 to to IN cord-016364-80l5mua2 20 44 infectious infectious JJ cord-016364-80l5mua2 20 45 disease disease NN cord-016364-80l5mua2 20 46 , , , cord-016364-80l5mua2 20 47 and and CC cord-016364-80l5mua2 20 48 mammalian mammalian JJ cord-016364-80l5mua2 20 49 genome genome NN cord-016364-80l5mua2 20 50 evolution evolution NN cord-016364-80l5mua2 20 51 . . . cord-016364-80l5mua2 21 1 2 2 LS cord-016364-80l5mua2 21 2 , , , cord-016364-80l5mua2 21 3 3 3 CD cord-016364-80l5mua2 22 1 To to TO cord-016364-80l5mua2 22 2 identify identify VB cord-016364-80l5mua2 22 3 genes gene NNS cord-016364-80l5mua2 22 4 associated associate VBN cord-016364-80l5mua2 22 5 with with IN cord-016364-80l5mua2 22 6 inherited inherit VBN cord-016364-80l5mua2 22 7 pathologies pathology NNS cord-016364-80l5mua2 22 8 that that WDT cord-016364-80l5mua2 22 9 mirror mirror VBP cord-016364-80l5mua2 22 10 inherited inherit VBD cord-016364-80l5mua2 22 11 human human JJ cord-016364-80l5mua2 22 12 conditions condition NNS cord-016364-80l5mua2 22 13 and and CC cord-016364-80l5mua2 22 14 interesting interesting JJ cord-016364-80l5mua2 22 15 pheno pheno NN cord-016364-80l5mua2 22 16 - - HYPH cord-016364-80l5mua2 22 17 types type NNS cord-016364-80l5mua2 22 18 in in IN cord-016364-80l5mua2 22 19 the the DT cord-016364-80l5mua2 22 20 domestic domestic JJ cord-016364-80l5mua2 22 21 cat cat NN cord-016364-80l5mua2 22 22 , , , cord-016364-80l5mua2 22 23 we -PRON- PRP cord-016364-80l5mua2 22 24 have have VBP cord-016364-80l5mua2 22 25 produced produce VBN cord-016364-80l5mua2 22 26 genetic genetic JJ cord-016364-80l5mua2 22 27 maps map NNS cord-016364-80l5mua2 22 28 of of IN cord-016364-80l5mua2 22 29 sufficient sufficient JJ cord-016364-80l5mua2 22 30 density density NN cord-016364-80l5mua2 22 31 to to TO cord-016364-80l5mua2 22 32 allow allow VB cord-016364-80l5mua2 22 33 linkage linkage NN cord-016364-80l5mua2 22 34 or or CC cord-016364-80l5mua2 22 35 association association NN cord-016364-80l5mua2 22 36 - - HYPH cord-016364-80l5mua2 22 37 based base VBN cord-016364-80l5mua2 22 38 mapping mapping NN cord-016364-80l5mua2 22 39 exercises exercise NNS cord-016364-80l5mua2 22 40 . . . cord-016364-80l5mua2 23 1 [ [ -LRB- cord-016364-80l5mua2 23 2 4 4 CD cord-016364-80l5mua2 23 3 ] ] -RRB- cord-016364-80l5mua2 23 4 [ [ -LRB- cord-016364-80l5mua2 23 5 5 5 CD cord-016364-80l5mua2 23 6 ] ] -RRB- cord-016364-80l5mua2 23 7 [ [ -LRB- cord-016364-80l5mua2 23 8 6 6 CD cord-016364-80l5mua2 23 9 ] ] -RRB- cord-016364-80l5mua2 23 10 [ [ -LRB- cord-016364-80l5mua2 23 11 7 7 CD cord-016364-80l5mua2 23 12 ] ] -RRB- cord-016364-80l5mua2 24 1 [ [ -LRB- cord-016364-80l5mua2 24 2 8 8 CD cord-016364-80l5mua2 24 3 ] ] -RRB- cord-016364-80l5mua2 24 4 [ [ -LRB- cord-016364-80l5mua2 24 5 9 9 CD cord-016364-80l5mua2 24 6 ] ] -RRB- cord-016364-80l5mua2 24 7 [ [ -LRB- cord-016364-80l5mua2 24 8 10 10 CD cord-016364-80l5mua2 24 9 ] ] -RRB- cord-016364-80l5mua2 24 10 [ [ -LRB- cord-016364-80l5mua2 24 11 11 11 CD cord-016364-80l5mua2 24 12 ] ] -RRB- cord-016364-80l5mua2 25 1 The the DT cord-016364-80l5mua2 25 2 first first JJ cord-016364-80l5mua2 25 3 genetic genetic JJ cord-016364-80l5mua2 25 4 map map NN cord-016364-80l5mua2 25 5 of of IN cord-016364-80l5mua2 25 6 the the DT cord-016364-80l5mua2 25 7 cat cat NN cord-016364-80l5mua2 25 8 , , , cord-016364-80l5mua2 25 9 a a DT cord-016364-80l5mua2 25 10 physical physical JJ cord-016364-80l5mua2 25 11 map map NN cord-016364-80l5mua2 25 12 generated generate VBN cord-016364-80l5mua2 25 13 from from IN cord-016364-80l5mua2 25 14 a a DT cord-016364-80l5mua2 25 15 somatic somatic JJ cord-016364-80l5mua2 25 16 - - HYPH cord-016364-80l5mua2 25 17 cell cell NN cord-016364-80l5mua2 25 18 hybrid hybrid NN cord-016364-80l5mua2 25 19 panel panel NN cord-016364-80l5mua2 25 20 , , , cord-016364-80l5mua2 25 21 demonstrated demonstrate VBD cord-016364-80l5mua2 25 22 the the DT cord-016364-80l5mua2 25 23 cat cat NN cord-016364-80l5mua2 25 24 's 's POS cord-016364-80l5mua2 25 25 high high JJ cord-016364-80l5mua2 25 26 level level NN cord-016364-80l5mua2 25 27 of of IN cord-016364-80l5mua2 25 28 conserved conserve VBN cord-016364-80l5mua2 25 29 synteny synteny NN cord-016364-80l5mua2 25 30 with with IN cord-016364-80l5mua2 25 31 the the DT cord-016364-80l5mua2 25 32 human human JJ cord-016364-80l5mua2 25 33 genome genome NN cord-016364-80l5mua2 25 34 , , , cord-016364-80l5mua2 25 35 which which WDT cord-016364-80l5mua2 25 36 offered offer VBD cord-016364-80l5mua2 25 37 much much JJ cord-016364-80l5mua2 25 38 promise promise NN cord-016364-80l5mua2 25 39 for for IN cord-016364-80l5mua2 25 40 the the DT cord-016364-80l5mua2 25 41 future future JJ cord-016364-80l5mua2 25 42 application application NN cord-016364-80l5mua2 25 43 of of IN cord-016364-80l5mua2 25 44 comparative comparative JJ cord-016364-80l5mua2 25 45 genomic genomic JJ cord-016364-80l5mua2 25 46 inference inference NN cord-016364-80l5mua2 25 47 in in IN cord-016364-80l5mua2 25 48 felid felid JJ cord-016364-80l5mua2 25 49 mapping mapping NN cord-016364-80l5mua2 25 50 and and CC cord-016364-80l5mua2 25 51 association association NN cord-016364-80l5mua2 25 52 exercises exercise NNS cord-016364-80l5mua2 25 53 . . . cord-016364-80l5mua2 26 1 12 12 CD cord-016364-80l5mua2 26 2 Several several JJ cord-016364-80l5mua2 26 3 radiation radiation NN cord-016364-80l5mua2 26 4 hybrid hybrid NN cord-016364-80l5mua2 26 5 ( ( -LRB- cord-016364-80l5mua2 26 6 RH RH NNP cord-016364-80l5mua2 26 7 ) ) -RRB- cord-016364-80l5mua2 26 8 and and CC cord-016364-80l5mua2 26 9 genetic genetic JJ cord-016364-80l5mua2 26 10 linkage linkage NN cord-016364-80l5mua2 26 11 ( ( -LRB- cord-016364-80l5mua2 26 12 GL GL NNP cord-016364-80l5mua2 26 13 ) ) -RRB- cord-016364-80l5mua2 26 14 maps map NNS cord-016364-80l5mua2 26 15 have have VBP cord-016364-80l5mua2 26 16 since since IN cord-016364-80l5mua2 26 17 been be VBN cord-016364-80l5mua2 26 18 published publish VBN cord-016364-80l5mua2 26 19 . . . cord-016364-80l5mua2 27 1 [ [ -LRB- cord-016364-80l5mua2 27 2 4 4 CD cord-016364-80l5mua2 27 3 ] ] -RRB- cord-016364-80l5mua2 27 4 [ [ -LRB- cord-016364-80l5mua2 27 5 5 5 CD cord-016364-80l5mua2 27 6 ] ] -RRB- cord-016364-80l5mua2 27 7 [ [ -LRB- cord-016364-80l5mua2 27 8 6 6 CD cord-016364-80l5mua2 27 9 ] ] -RRB- cord-016364-80l5mua2 27 10 [ [ -LRB- cord-016364-80l5mua2 27 11 7 7 CD cord-016364-80l5mua2 27 12 ] ] -RRB- cord-016364-80l5mua2 28 1 [ [ -LRB- cord-016364-80l5mua2 28 2 8 8 CD cord-016364-80l5mua2 28 3 ] ] -RRB- cord-016364-80l5mua2 28 4 [ [ -LRB- cord-016364-80l5mua2 28 5 9 9 CD cord-016364-80l5mua2 28 6 ] ] -RRB- cord-016364-80l5mua2 28 7 11 11 CD cord-016364-80l5mua2 28 8 , , , cord-016364-80l5mua2 28 9 13 13 CD cord-016364-80l5mua2 28 10 , , , cord-016364-80l5mua2 28 11 14 14 CD cord-016364-80l5mua2 28 12 _SP cord-016364-80l5mua2 29 1 Although although IN cord-016364-80l5mua2 29 2 previous previous JJ cord-016364-80l5mua2 29 3 versions version NNS cord-016364-80l5mua2 29 4 of of IN cord-016364-80l5mua2 29 5 the the DT cord-016364-80l5mua2 29 6 cat cat NN cord-016364-80l5mua2 29 7 gene gene NN cord-016364-80l5mua2 29 8 map map NNP cord-016364-80l5mua2 29 9 , , , cord-016364-80l5mua2 29 10 based base VBN cord-016364-80l5mua2 29 11 on on IN cord-016364-80l5mua2 29 12 somatic somatic JJ cord-016364-80l5mua2 29 13 cell cell NN cord-016364-80l5mua2 29 14 hybrid hybrid NN cord-016364-80l5mua2 29 15 and and CC cord-016364-80l5mua2 29 16 ZOO ZOO NNP cord-016364-80l5mua2 29 17 FISH fish NN cord-016364-80l5mua2 29 18 analysis analysis NN cord-016364-80l5mua2 29 19 , , , cord-016364-80l5mua2 29 20 15 15 CD cord-016364-80l5mua2 29 21 , , , cord-016364-80l5mua2 29 22 16 16 CD cord-016364-80l5mua2 29 23 revealed reveal VBD cord-016364-80l5mua2 29 24 considerable considerable JJ cord-016364-80l5mua2 29 25 conservation conservation NN cord-016364-80l5mua2 29 26 of of IN cord-016364-80l5mua2 29 27 synteny synteny NN cord-016364-80l5mua2 29 28 with with IN cord-016364-80l5mua2 29 29 the the DT cord-016364-80l5mua2 29 30 human human JJ cord-016364-80l5mua2 29 31 genome genome NN cord-016364-80l5mua2 29 32 , , , cord-016364-80l5mua2 29 33 these these DT cord-016364-80l5mua2 29 34 maps map NNS cord-016364-80l5mua2 29 35 provided provide VBD cord-016364-80l5mua2 29 36 no no DT cord-016364-80l5mua2 29 37 knowledge knowledge NN cord-016364-80l5mua2 29 38 of of IN cord-016364-80l5mua2 29 39 gene gene NN cord-016364-80l5mua2 29 40 order order NN cord-016364-80l5mua2 29 41 or or CC cord-016364-80l5mua2 29 42 intrachromosomal intrachromosomal NNP cord-016364-80l5mua2 29 43 genome genome NN cord-016364-80l5mua2 29 44 rearrangement rearrangement NN cord-016364-80l5mua2 29 45 between between IN cord-016364-80l5mua2 29 46 the the DT cord-016364-80l5mua2 29 47 two two CD cord-016364-80l5mua2 29 48 species specie NNS cord-016364-80l5mua2 29 49 , , , cord-016364-80l5mua2 29 50 information information NN cord-016364-80l5mua2 29 51 that that WDT cord-016364-80l5mua2 29 52 is be VBZ cord-016364-80l5mua2 29 53 critical critical JJ cord-016364-80l5mua2 29 54 to to IN cord-016364-80l5mua2 29 55 applying apply VBG cord-016364-80l5mua2 29 56 comparative comparative JJ cord-016364-80l5mua2 29 57 map map NN cord-016364-80l5mua2 29 58 inference inference NN cord-016364-80l5mua2 29 59 to to TO cord-016364-80l5mua2 29 60 gene gene VB cord-016364-80l5mua2 29 61 dis dis NNP cord-016364-80l5mua2 29 62 covery covery NN cord-016364-80l5mua2 29 63 in in IN cord-016364-80l5mua2 29 64 gene gene NN cord-016364-80l5mua2 29 65 - - HYPH cord-016364-80l5mua2 29 66 poor poor JJ cord-016364-80l5mua2 29 67 model model NN cord-016364-80l5mua2 29 68 systems system NNS cord-016364-80l5mua2 29 69 . . . cord-016364-80l5mua2 30 1 Radiation radiation NN cord-016364-80l5mua2 30 2 hybrid hybrid NN cord-016364-80l5mua2 30 3 ( ( -LRB- cord-016364-80l5mua2 30 4 RH RH NNP cord-016364-80l5mua2 30 5 ) ) -RRB- cord-016364-80l5mua2 30 6 mapping mapping NN cord-016364-80l5mua2 30 7 has have VBZ cord-016364-80l5mua2 30 8 emerged emerge VBN cord-016364-80l5mua2 30 9 as as IN cord-016364-80l5mua2 30 10 a a DT cord-016364-80l5mua2 30 11 powerful powerful JJ cord-016364-80l5mua2 30 12 tool tool NN cord-016364-80l5mua2 30 13 for for IN cord-016364-80l5mua2 30 14 constructing construct VBG cord-016364-80l5mua2 30 15 moderate moderate JJ cord-016364-80l5mua2 30 16 - - HYPH cord-016364-80l5mua2 30 17 to to IN cord-016364-80l5mua2 30 18 high high JJ cord-016364-80l5mua2 30 19 - - HYPH cord-016364-80l5mua2 30 20 density density NN cord-016364-80l5mua2 30 21 gene gene NN cord-016364-80l5mua2 30 22 maps map NNS cord-016364-80l5mua2 30 23 in in IN cord-016364-80l5mua2 30 24 vertebrates vertebrate NNS cord-016364-80l5mua2 30 25 by by IN cord-016364-80l5mua2 30 26 obviating obviate VBG cord-016364-80l5mua2 30 27 the the DT cord-016364-80l5mua2 30 28 need need NN cord-016364-80l5mua2 30 29 to to TO cord-016364-80l5mua2 30 30 identify identify VB cord-016364-80l5mua2 30 31 interspecific interspecific JJ cord-016364-80l5mua2 30 32 polymorphisms polymorphism NNS cord-016364-80l5mua2 30 33 critical critical JJ cord-016364-80l5mua2 30 34 for for IN cord-016364-80l5mua2 30 35 the the DT cord-016364-80l5mua2 30 36 generation generation NN cord-016364-80l5mua2 30 37 of of IN cord-016364-80l5mua2 30 38 genetic genetic JJ cord-016364-80l5mua2 30 39 linkage linkage NN cord-016364-80l5mua2 30 40 maps map NNS cord-016364-80l5mua2 30 41 . . . cord-016364-80l5mua2 31 1 7 7 CD cord-016364-80l5mua2 32 1 The the DT cord-016364-80l5mua2 32 2 most most RBS cord-016364-80l5mua2 32 3 recent recent JJ cord-016364-80l5mua2 32 4 RH RH NNP cord-016364-80l5mua2 32 5 map map NN cord-016364-80l5mua2 32 6 of of IN cord-016364-80l5mua2 32 7 the the DT cord-016364-80l5mua2 32 8 cat cat NN cord-016364-80l5mua2 32 9 8 8 CD cord-016364-80l5mua2 32 10 includes include VBZ cord-016364-80l5mua2 32 11 1793 1793 CD cord-016364-80l5mua2 32 12 markers marker NNS cord-016364-80l5mua2 32 13 : : : cord-016364-80l5mua2 32 14 662 662 CD cord-016364-80l5mua2 32 15 coding code VBG cord-016364-80l5mua2 32 16 loci locus NNS cord-016364-80l5mua2 32 17 , , , cord-016364-80l5mua2 32 18 335 335 CD cord-016364-80l5mua2 32 19 selected select VBN cord-016364-80l5mua2 32 20 markers marker NNS cord-016364-80l5mua2 32 21 derived derive VBN cord-016364-80l5mua2 32 22 from from IN cord-016364-80l5mua2 32 23 the the DT cord-016364-80l5mua2 32 24 cat cat NN cord-016364-80l5mua2 32 25 2X 2x CD cord-016364-80l5mua2 32 26 whole whole JJ cord-016364-80l5mua2 32 27 genome genome NN cord-016364-80l5mua2 32 28 sequence sequence NN cord-016364-80l5mua2 32 29 targeted target VBN cord-016364-80l5mua2 32 30 at at IN cord-016364-80l5mua2 32 31 breakpoints breakpoint NNS cord-016364-80l5mua2 32 32 in in IN cord-016364-80l5mua2 32 33 conserved conserve VBN cord-016364-80l5mua2 32 34 synteny synteny NN cord-016364-80l5mua2 32 35 between between IN cord-016364-80l5mua2 32 36 human human NN cord-016364-80l5mua2 32 37 and and CC cord-016364-80l5mua2 32 38 cat cat NN cord-016364-80l5mua2 32 39 , , , cord-016364-80l5mua2 32 40 and and CC cord-016364-80l5mua2 32 41 797 797 CD cord-016364-80l5mua2 32 42 short short JJ cord-016364-80l5mua2 32 43 tandem tandem NN cord-016364-80l5mua2 32 44 repeat repeat NN cord-016364-80l5mua2 32 45 ( ( -LRB- cord-016364-80l5mua2 32 46 STR str NN cord-016364-80l5mua2 32 47 ) ) -RRB- cord-016364-80l5mua2 32 48 loci locus NNS cord-016364-80l5mua2 32 49 . . . cord-016364-80l5mua2 33 1 The the DT cord-016364-80l5mua2 33 2 strategy strategy NN cord-016364-80l5mua2 33 3 used use VBN cord-016364-80l5mua2 33 4 in in IN cord-016364-80l5mua2 33 5 developing develop VBG cord-016364-80l5mua2 33 6 the the DT cord-016364-80l5mua2 33 7 current current JJ cord-016364-80l5mua2 33 8 RH RH NNP cord-016364-80l5mua2 33 9 map map NN cord-016364-80l5mua2 33 10 was be VBD cord-016364-80l5mua2 33 11 to to TO cord-016364-80l5mua2 33 12 target target VB cord-016364-80l5mua2 33 13 gaps gap NNS cord-016364-80l5mua2 33 14 in in IN cord-016364-80l5mua2 33 15 the the DT cord-016364-80l5mua2 33 16 feline feline JJ cord-016364-80l5mua2 33 17 - - HYPH cord-016364-80l5mua2 33 18 human human JJ cord-016364-80l5mua2 33 19 comparative comparative JJ cord-016364-80l5mua2 33 20 map map NN cord-016364-80l5mua2 33 21 , , , cord-016364-80l5mua2 33 22 and and CC cord-016364-80l5mua2 33 23 to to TO cord-016364-80l5mua2 33 24 provide provide VB cord-016364-80l5mua2 33 25 more more JJR cord-016364-80l5mua2 33 26 definition definition NN cord-016364-80l5mua2 33 27 in in IN cord-016364-80l5mua2 33 28 breakpoints breakpoint NNS cord-016364-80l5mua2 33 29 in in IN cord-016364-80l5mua2 33 30 regions region NNS cord-016364-80l5mua2 33 31 of of IN cord-016364-80l5mua2 33 32 conserved conserve VBN cord-016364-80l5mua2 33 33 synteny synteny NN cord-016364-80l5mua2 33 34 between between IN cord-016364-80l5mua2 33 35 cat cat NN cord-016364-80l5mua2 33 36 and and CC cord-016364-80l5mua2 33 37 human human NN cord-016364-80l5mua2 33 38 . . . cord-016364-80l5mua2 34 1 The the DT cord-016364-80l5mua2 34 2 1793 1793 CD cord-016364-80l5mua2 34 3 markers marker NNS cord-016364-80l5mua2 34 4 cover cover VBP cord-016364-80l5mua2 34 5 the the DT cord-016364-80l5mua2 34 6 length length NN cord-016364-80l5mua2 34 7 of of IN cord-016364-80l5mua2 34 8 the the DT cord-016364-80l5mua2 34 9 18 18 CD cord-016364-80l5mua2 34 10 feline feline JJ cord-016364-80l5mua2 34 11 autosomes autosome NNS cord-016364-80l5mua2 34 12 and and CC cord-016364-80l5mua2 34 13 the the DT cord-016364-80l5mua2 34 14 X x NN cord-016364-80l5mua2 34 15 chromosome chromosome NN cord-016364-80l5mua2 34 16 at at IN cord-016364-80l5mua2 34 17 an an DT cord-016364-80l5mua2 34 18 average average JJ cord-016364-80l5mua2 34 19 spacing spacing NN cord-016364-80l5mua2 34 20 of of IN cord-016364-80l5mua2 34 21 one one CD cord-016364-80l5mua2 34 22 marker marker NN cord-016364-80l5mua2 34 23 every every DT cord-016364-80l5mua2 34 24 1.5 1.5 CD cord-016364-80l5mua2 34 25 Mb Mb NNP cord-016364-80l5mua2 34 26 ( ( -LRB- cord-016364-80l5mua2 34 27 megabase megabase NNP cord-016364-80l5mua2 34 28 ) ) -RRB- cord-016364-80l5mua2 34 29 , , , cord-016364-80l5mua2 34 30 with with IN cord-016364-80l5mua2 34 31 fairly fairly RB cord-016364-80l5mua2 34 32 uniform uniform JJ cord-016364-80l5mua2 34 33 marker marker NN cord-016364-80l5mua2 34 34 density density NN cord-016364-80l5mua2 34 35 . . . cord-016364-80l5mua2 35 1 8 8 CD cord-016364-80l5mua2 36 1 An an DT cord-016364-80l5mua2 36 2 enhanced enhanced JJ cord-016364-80l5mua2 36 3 comparative comparative JJ cord-016364-80l5mua2 36 4 map map NN cord-016364-80l5mua2 36 5 demonstrates demonstrate VBZ cord-016364-80l5mua2 36 6 that that IN cord-016364-80l5mua2 36 7 the the DT cord-016364-80l5mua2 36 8 current current JJ cord-016364-80l5mua2 36 9 map map NN cord-016364-80l5mua2 36 10 provides provide VBZ cord-016364-80l5mua2 36 11 86 86 CD cord-016364-80l5mua2 36 12 % % NN cord-016364-80l5mua2 36 13 and and CC cord-016364-80l5mua2 36 14 85 85 CD cord-016364-80l5mua2 36 15 % % NN cord-016364-80l5mua2 36 16 comparative comparative JJ cord-016364-80l5mua2 36 17 coverage coverage NN cord-016364-80l5mua2 36 18 of of IN cord-016364-80l5mua2 36 19 the the DT cord-016364-80l5mua2 36 20 human human JJ cord-016364-80l5mua2 36 21 and and CC cord-016364-80l5mua2 36 22 canine canine JJ cord-016364-80l5mua2 36 23 genomes genome NNS cord-016364-80l5mua2 36 24 , , , cord-016364-80l5mua2 36 25 respectively respectively RB cord-016364-80l5mua2 36 26 . . . cord-016364-80l5mua2 37 1 8 8 CD cord-016364-80l5mua2 37 2 Ninety ninety CD cord-016364-80l5mua2 37 3 - - HYPH cord-016364-80l5mua2 37 4 six six CD cord-016364-80l5mua2 37 5 percent percent NN cord-016364-80l5mua2 37 6 of of IN cord-016364-80l5mua2 37 7 the the DT cord-016364-80l5mua2 37 8 1793 1793 CD cord-016364-80l5mua2 37 9 cat cat NN cord-016364-80l5mua2 37 10 markers marker NNS cord-016364-80l5mua2 37 11 have have VBP cord-016364-80l5mua2 37 12 identifi identifi VBN cord-016364-80l5mua2 37 13 able able JJ cord-016364-80l5mua2 37 14 orthologues orthologue NNS cord-016364-80l5mua2 37 15 in in IN cord-016364-80l5mua2 37 16 the the DT cord-016364-80l5mua2 37 17 canine canine JJ cord-016364-80l5mua2 37 18 and and CC cord-016364-80l5mua2 37 19 human human JJ cord-016364-80l5mua2 37 20 genome genome NN cord-016364-80l5mua2 37 21 sequences sequence NNS cord-016364-80l5mua2 37 22 , , , cord-016364-80l5mua2 37 23 providing provide VBG cord-016364-80l5mua2 37 24 a a DT cord-016364-80l5mua2 37 25 rich rich JJ cord-016364-80l5mua2 37 26 comparative comparative JJ cord-016364-80l5mua2 37 27 tool tool NN cord-016364-80l5mua2 37 28 , , , cord-016364-80l5mua2 37 29 which which WDT cord-016364-80l5mua2 37 30 is be VBZ cord-016364-80l5mua2 37 31 critical critical JJ cord-016364-80l5mua2 37 32 in in IN cord-016364-80l5mua2 37 33 linkage linkage NN cord-016364-80l5mua2 37 34 mapping mapping NN cord-016364-80l5mua2 37 35 exercises exercise NNS cord-016364-80l5mua2 37 36 for for IN cord-016364-80l5mua2 37 37 the the DT cord-016364-80l5mua2 37 38 identification identification NN cord-016364-80l5mua2 37 39 of of IN cord-016364-80l5mua2 37 40 genes gene NNS cord-016364-80l5mua2 37 41 controlling control VBG cord-016364-80l5mua2 37 42 feline feline JJ cord-016364-80l5mua2 37 43 phenotypes phenotype NNS cord-016364-80l5mua2 37 44 . . . cord-016364-80l5mua2 38 1 Figure figure NN cord-016364-80l5mua2 38 2 25 25 CD cord-016364-80l5mua2 38 3 -1 -1 NN cord-016364-80l5mua2 38 4 presents present VBZ cord-016364-80l5mua2 38 5 a a DT cord-016364-80l5mua2 38 6 graphic graphic JJ cord-016364-80l5mua2 38 7 display display NN cord-016364-80l5mua2 38 8 of of IN cord-016364-80l5mua2 38 9 each each DT cord-016364-80l5mua2 38 10 cat cat NN cord-016364-80l5mua2 38 11 chromosome chromosome NN cord-016364-80l5mua2 38 12 and and CC cord-016364-80l5mua2 38 13 blocks block NNS cord-016364-80l5mua2 38 14 of of IN cord-016364-80l5mua2 38 15 conserved conserve VBN cord-016364-80l5mua2 38 16 syntenic syntenic JJ cord-016364-80l5mua2 38 17 order order NN cord-016364-80l5mua2 38 18 with with IN cord-016364-80l5mua2 38 19 the the DT cord-016364-80l5mua2 38 20 human human JJ cord-016364-80l5mua2 38 21 and and CC cord-016364-80l5mua2 38 22 canine canine JJ cord-016364-80l5mua2 38 23 genomes genome NNS cord-016364-80l5mua2 38 24 . . . cord-016364-80l5mua2 39 1 8 8 CD cord-016364-80l5mua2 40 1 One one CD cord-016364-80l5mua2 40 2 hundred hundred CD cord-016364-80l5mua2 40 3 and and CC cord-016364-80l5mua2 40 4 fifty fifty CD cord-016364-80l5mua2 40 5 - - HYPH cord-016364-80l5mua2 40 6 two two CD cord-016364-80l5mua2 40 7 cat cat NN cord-016364-80l5mua2 40 8 - - HYPH cord-016364-80l5mua2 40 9 human human NN cord-016364-80l5mua2 40 10 and and CC cord-016364-80l5mua2 40 11 134 134 CD cord-016364-80l5mua2 40 12 cat cat NN cord-016364-80l5mua2 40 13 - - HYPH cord-016364-80l5mua2 40 14 dog dog NN cord-016364-80l5mua2 40 15 homologous homologous JJ cord-016364-80l5mua2 40 16 synteny synteny NN cord-016364-80l5mua2 40 17 blocks block NNS cord-016364-80l5mua2 40 18 were be VBD cord-016364-80l5mua2 40 19 identified identify VBN cord-016364-80l5mua2 40 20 . . . cord-016364-80l5mua2 41 1 Alignment alignment NN cord-016364-80l5mua2 41 2 of of IN cord-016364-80l5mua2 41 3 cat cat NN cord-016364-80l5mua2 41 4 , , , cord-016364-80l5mua2 41 5 dog dog NN cord-016364-80l5mua2 41 6 , , , cord-016364-80l5mua2 41 7 and and CC cord-016364-80l5mua2 41 8 human human JJ cord-016364-80l5mua2 41 9 chromosomes chromosome NNS cord-016364-80l5mua2 41 10 demonstrated demonstrate VBD cord-016364-80l5mua2 41 11 different different JJ cord-016364-80l5mua2 41 12 patterns pattern NNS cord-016364-80l5mua2 41 13 of of IN cord-016364-80l5mua2 41 14 chromosomal chromosomal JJ cord-016364-80l5mua2 41 15 rearrangement rearrangement NN cord-016364-80l5mua2 41 16 with with IN cord-016364-80l5mua2 41 17 a a DT cord-016364-80l5mua2 41 18 marked marked JJ cord-016364-80l5mua2 41 19 increase increase NN cord-016364-80l5mua2 41 20 in in IN cord-016364-80l5mua2 41 21 interchromosomal interchromosomal JJ cord-016364-80l5mua2 41 22 rearrangements rearrangement NNS cord-016364-80l5mua2 41 23 relative relative JJ cord-016364-80l5mua2 41 24 to to IN cord-016364-80l5mua2 41 25 human human NN cord-016364-80l5mua2 41 26 in in IN cord-016364-80l5mua2 41 27 the the DT cord-016364-80l5mua2 41 28 canid canid JJ cord-016364-80l5mua2 41 29 lineage lineage NN cord-016364-80l5mua2 41 30 ( ( -LRB- cord-016364-80l5mua2 41 31 89 89 CD cord-016364-80l5mua2 41 32 % % NN cord-016364-80l5mua2 41 33 of of IN cord-016364-80l5mua2 41 34 all all DT cord-016364-80l5mua2 41 35 rearrangements rearrangement NNS cord-016364-80l5mua2 41 36 ) ) -RRB- cord-016364-80l5mua2 41 37 , , , cord-016364-80l5mua2 41 38 as as IN cord-016364-80l5mua2 41 39 opposed oppose VBN cord-016364-80l5mua2 41 40 to to IN cord-016364-80l5mua2 41 41 the the DT cord-016364-80l5mua2 41 42 more more RBR cord-016364-80l5mua2 41 43 frequent frequent JJ cord-016364-80l5mua2 41 44 intrachromosomal intrachromosomal JJ cord-016364-80l5mua2 41 45 rearrangements rearrangement NNS cord-016364-80l5mua2 41 46 in in IN cord-016364-80l5mua2 41 47 the the DT cord-016364-80l5mua2 41 48 felid felid JJ cord-016364-80l5mua2 41 49 lineage lineage NN cord-016364-80l5mua2 41 50 ( ( -LRB- cord-016364-80l5mua2 41 51 95 95 CD cord-016364-80l5mua2 41 52 % % NN cord-016364-80l5mua2 41 53 of of IN cord-016364-80l5mua2 41 54 all all DT cord-016364-80l5mua2 41 55 rearrangements rearrangement NNS cord-016364-80l5mua2 41 56 ) ) -RRB- cord-016364-80l5mua2 41 57 since since IN cord-016364-80l5mua2 41 58 divergence divergence NN cord-016364-80l5mua2 41 59 from from IN cord-016364-80l5mua2 41 60 a a DT cord-016364-80l5mua2 41 61 common common JJ cord-016364-80l5mua2 41 62 carnivore carnivore NN cord-016364-80l5mua2 41 63 ancestor ancestor NN cord-016364-80l5mua2 41 64 55 55 CD cord-016364-80l5mua2 42 1 My -PRON- PRP$ cord-016364-80l5mua2 42 2 ago ago RB cord-016364-80l5mua2 42 3 . . . cord-016364-80l5mua2 43 1 With with IN cord-016364-80l5mua2 43 2 an an DT cord-016364-80l5mua2 43 3 average average JJ cord-016364-80l5mua2 43 4 spacing spacing NN cord-016364-80l5mua2 43 5 of of IN cord-016364-80l5mua2 43 6 1 1 CD cord-016364-80l5mua2 43 7 marker marker NN cord-016364-80l5mua2 43 8 every every DT cord-016364-80l5mua2 43 9 1.5 1.5 CD cord-016364-80l5mua2 43 10 Mb Mb NNS cord-016364-80l5mua2 43 11 in in IN cord-016364-80l5mua2 43 12 the the DT cord-016364-80l5mua2 43 13 feline feline JJ cord-016364-80l5mua2 43 14 euchromatic euchromatic JJ cord-016364-80l5mua2 43 15 sequence sequence NN cord-016364-80l5mua2 43 16 , , , cord-016364-80l5mua2 43 17 the the DT cord-016364-80l5mua2 43 18 map map NN cord-016364-80l5mua2 43 19 provided provide VBD cord-016364-80l5mua2 43 20 a a DT cord-016364-80l5mua2 43 21 solid solid JJ cord-016364-80l5mua2 43 22 framework framework NN cord-016364-80l5mua2 43 23 for for IN cord-016364-80l5mua2 43 24 the the DT cord-016364-80l5mua2 43 25 chromosomal chromosomal JJ cord-016364-80l5mua2 43 26 assignment assignment NN cord-016364-80l5mua2 43 27 of of IN cord-016364-80l5mua2 43 28 feline feline JJ cord-016364-80l5mua2 43 29 contigs contig NNS cord-016364-80l5mua2 43 30 and and CC cord-016364-80l5mua2 43 31 scaffolds scaffold NNS cord-016364-80l5mua2 43 32 during during IN cord-016364-80l5mua2 43 33 assembly assembly NN cord-016364-80l5mua2 43 34 of of IN cord-016364-80l5mua2 43 35 the the DT cord-016364-80l5mua2 43 36 cat cat NN cord-016364-80l5mua2 43 37 genome genome NNP cord-016364-80l5mua2 43 38 assembly assembly NN cord-016364-80l5mua2 43 39 , , , cord-016364-80l5mua2 43 40 17 17 CD cord-016364-80l5mua2 43 41 and and CC cord-016364-80l5mua2 43 42 served serve VBD cord-016364-80l5mua2 43 43 as as IN cord-016364-80l5mua2 43 44 a a DT cord-016364-80l5mua2 43 45 comparative comparative JJ cord-016364-80l5mua2 43 46 tool tool NN cord-016364-80l5mua2 43 47 to to TO cord-016364-80l5mua2 43 48 aid aid VB cord-016364-80l5mua2 43 49 in in IN cord-016364-80l5mua2 43 50 the the DT cord-016364-80l5mua2 43 51 identification identification NN cord-016364-80l5mua2 43 52 of of IN cord-016364-80l5mua2 43 53 genes gene NNS cord-016364-80l5mua2 43 54 controlling control VBG cord-016364-80l5mua2 43 55 feline feline JJ cord-016364-80l5mua2 43 56 phenotypes phenotype NNS cord-016364-80l5mua2 43 57 . . . cord-016364-80l5mua2 43 58 _SP cord-016364-80l5mua2 44 1 As as IN cord-016364-80l5mua2 44 2 a a DT cord-016364-80l5mua2 44 3 complement complement NN cord-016364-80l5mua2 44 4 to to IN cord-016364-80l5mua2 44 5 the the DT cord-016364-80l5mua2 44 6 RH RH NNP cord-016364-80l5mua2 44 7 map map NN cord-016364-80l5mua2 44 8 of of IN cord-016364-80l5mua2 44 9 the the DT cord-016364-80l5mua2 44 10 cat cat NN cord-016364-80l5mua2 44 11 , , , cord-016364-80l5mua2 44 12 a a DT cord-016364-80l5mua2 44 13 third third JJ cord-016364-80l5mua2 44 14 generation generation NN cord-016364-80l5mua2 44 15 linkage linkage NN cord-016364-80l5mua2 44 16 map map NN cord-016364-80l5mua2 44 17 of of IN cord-016364-80l5mua2 44 18 625 625 CD cord-016364-80l5mua2 44 19 STRs STRs NNPS cord-016364-80l5mua2 44 20 is be VBZ cord-016364-80l5mua2 44 21 currently currently RB cord-016364-80l5mua2 44 22 nearing near VBG cord-016364-80l5mua2 44 23 completion completion NN cord-016364-80l5mua2 44 24 . . . cord-016364-80l5mua2 45 1 The the DT cord-016364-80l5mua2 45 2 map map NN cord-016364-80l5mua2 45 3 has have VBZ cord-016364-80l5mua2 45 4 been be VBN cord-016364-80l5mua2 45 5 generated generate VBN cord-016364-80l5mua2 45 6 in in IN cord-016364-80l5mua2 45 7 a a DT cord-016364-80l5mua2 45 8 large large JJ cord-016364-80l5mua2 45 9 multigeneration multigeneration NN cord-016364-80l5mua2 45 10 domestic domestic JJ cord-016364-80l5mua2 45 11 cat cat NN cord-016364-80l5mua2 45 12 pedigree pedigree NN cord-016364-80l5mua2 45 13 ( ( -LRB- cord-016364-80l5mua2 45 14 n n NN cord-016364-80l5mua2 45 15 = = SYM cord-016364-80l5mua2 45 16 483 483 CD cord-016364-80l5mua2 45 17 informative informative JJ cord-016364-80l5mua2 45 18 meioses meiosis NNS cord-016364-80l5mua2 45 19 ) ) -RRB- cord-016364-80l5mua2 45 20 . . . cord-016364-80l5mua2 46 1 18 18 CD cord-016364-80l5mua2 47 1 Previous previous JJ cord-016364-80l5mua2 47 2 first first JJ cord-016364-80l5mua2 47 3 - - HYPH cord-016364-80l5mua2 47 4 and and CC cord-016364-80l5mua2 47 5 second second JJ cord-016364-80l5mua2 47 6 - - HYPH cord-016364-80l5mua2 47 7 generation generation NN cord-016364-80l5mua2 47 8 linkage linkage NN cord-016364-80l5mua2 47 9 maps map NNS cord-016364-80l5mua2 47 10 of of IN cord-016364-80l5mua2 47 11 the the DT cord-016364-80l5mua2 47 12 cat cat NN cord-016364-80l5mua2 47 13 were be VBD cord-016364-80l5mua2 47 14 generated generate VBN cord-016364-80l5mua2 47 15 in in IN cord-016364-80l5mua2 47 16 a a DT cord-016364-80l5mua2 47 17 multigeneration multigeneration NN cord-016364-80l5mua2 47 18 interspecies interspecie NNS cord-016364-80l5mua2 47 19 pedigree pedigree NN cord-016364-80l5mua2 47 20 generated generate VBN cord-016364-80l5mua2 47 21 between between IN cord-016364-80l5mua2 47 22 the the DT cord-016364-80l5mua2 47 23 domestic domestic JJ cord-016364-80l5mua2 47 24 cat cat NN cord-016364-80l5mua2 47 25 and and CC cord-016364-80l5mua2 47 26 the the DT cord-016364-80l5mua2 47 27 Asian asian JJ cord-016364-80l5mua2 47 28 leopard leopard NN cord-016364-80l5mua2 47 29 cat cat NN cord-016364-80l5mua2 47 30 , , , cord-016364-80l5mua2 47 31 Prionailurus Prionailurus NNP cord-016364-80l5mua2 47 32 bengalensis bengalensis NN cord-016364-80l5mua2 47 33 , , , cord-016364-80l5mua2 47 34 7 7 CD cord-016364-80l5mua2 47 35 to to TO cord-016364-80l5mua2 47 36 facilitate facilitate VB cord-016364-80l5mua2 47 37 the the DT cord-016364-80l5mua2 47 38 mapping mapping NN cord-016364-80l5mua2 47 39 and and CC cord-016364-80l5mua2 47 40 integration integration NN cord-016364-80l5mua2 47 41 of of IN cord-016364-80l5mua2 47 42 Type type NN cord-016364-80l5mua2 47 43 I -PRON- PRP cord-016364-80l5mua2 47 44 ( ( -LRB- cord-016364-80l5mua2 47 45 coding code VBG cord-016364-80l5mua2 47 46 ) ) -RRB- cord-016364-80l5mua2 47 47 and and CC cord-016364-80l5mua2 47 48 Type Type NNP cord-016364-80l5mua2 47 49 II II NNP cord-016364-80l5mua2 47 50 ( ( -LRB- cord-016364-80l5mua2 47 51 polymorphic polymorphic JJ cord-016364-80l5mua2 47 52 STR str NN cord-016364-80l5mua2 47 53 ) ) -RRB- cord-016364-80l5mua2 47 54 loci locus NNS cord-016364-80l5mua2 47 55 . . . cord-016364-80l5mua2 48 1 7 7 CD cord-016364-80l5mua2 49 1 The the DT cord-016364-80l5mua2 49 2 current current JJ cord-016364-80l5mua2 49 3 map map NN cord-016364-80l5mua2 49 4 , , , cord-016364-80l5mua2 49 5 which which WDT cord-016364-80l5mua2 49 6 spans span VBZ cord-016364-80l5mua2 49 7 all all DT cord-016364-80l5mua2 49 8 18 18 CD cord-016364-80l5mua2 49 9 autosomes autosome NNS cord-016364-80l5mua2 49 10 with with IN cord-016364-80l5mua2 49 11 single single JJ cord-016364-80l5mua2 49 12 linkage linkage NN cord-016364-80l5mua2 49 13 groups group NNS cord-016364-80l5mua2 49 14 , , , cord-016364-80l5mua2 49 15 has have VBZ cord-016364-80l5mua2 49 16 twice twice PDT cord-016364-80l5mua2 49 17 the the DT cord-016364-80l5mua2 49 18 STR str NN cord-016364-80l5mua2 49 19 density density NN cord-016364-80l5mua2 49 20 of of IN cord-016364-80l5mua2 49 21 previous previous JJ cord-016364-80l5mua2 49 22 maps map NNS cord-016364-80l5mua2 49 23 , , , cord-016364-80l5mua2 49 24 providing provide VBG cord-016364-80l5mua2 49 25 a a DT cord-016364-80l5mua2 49 26 5-cM 5-cm CD cord-016364-80l5mua2 49 27 resolution resolution NN cord-016364-80l5mua2 49 28 . . . cord-016364-80l5mua2 50 1 There there EX cord-016364-80l5mua2 50 2 is be VBZ cord-016364-80l5mua2 50 3 also also RB cord-016364-80l5mua2 50 4 greatly greatly RB cord-016364-80l5mua2 50 5 expanded expand VBN cord-016364-80l5mua2 50 6 coverage coverage NN cord-016364-80l5mua2 50 7 of of IN cord-016364-80l5mua2 50 8 the the DT cord-016364-80l5mua2 50 9 X x NN cord-016364-80l5mua2 50 10 chromosome chromosome NN cord-016364-80l5mua2 50 11 , , , cord-016364-80l5mua2 50 12 with with IN cord-016364-80l5mua2 50 13 some some DT cord-016364-80l5mua2 50 14 75 75 CD cord-016364-80l5mua2 50 15 STR str NN cord-016364-80l5mua2 50 16 loci locus NNS cord-016364-80l5mua2 50 17 . . . cord-016364-80l5mua2 51 1 Marker marker NN cord-016364-80l5mua2 51 2 order order NN cord-016364-80l5mua2 51 3 between between IN cord-016364-80l5mua2 51 4 the the DT cord-016364-80l5mua2 51 5 current current JJ cord-016364-80l5mua2 51 6 generation generation NN cord-016364-80l5mua2 51 7 RH RH NNP cord-016364-80l5mua2 51 8 and and CC cord-016364-80l5mua2 51 9 GL GL NNP cord-016364-80l5mua2 51 10 maps map NNS cord-016364-80l5mua2 51 11 is be VBZ cord-016364-80l5mua2 51 12 highly highly RB cord-016364-80l5mua2 51 13 concordant concordant JJ cord-016364-80l5mua2 51 14 . . . cord-016364-80l5mua2 52 1 8 8 CD cord-016364-80l5mua2 52 2 Approximately approximately RB cord-016364-80l5mua2 52 3 85 85 CD cord-016364-80l5mua2 52 4 % % NN cord-016364-80l5mua2 52 5 of of IN cord-016364-80l5mua2 52 6 the the DT cord-016364-80l5mua2 52 7 STRs STRs NNPS cord-016364-80l5mua2 52 8 are be VBP cord-016364-80l5mua2 52 9 mapped map VBN cord-016364-80l5mua2 52 10 in in IN cord-016364-80l5mua2 52 11 the the DT cord-016364-80l5mua2 52 12 most most RBS cord-016364-80l5mua2 52 13 current current JJ cord-016364-80l5mua2 52 14 RH RH NNP cord-016364-80l5mua2 52 15 map map NN cord-016364-80l5mua2 52 16 of of IN cord-016364-80l5mua2 52 17 the the DT cord-016364-80l5mua2 52 18 cat cat NN cord-016364-80l5mua2 52 19 , , , cord-016364-80l5mua2 52 20 8 8 CD cord-016364-80l5mua2 52 21 which which WDT cord-016364-80l5mua2 52 22 provides provide VBZ cord-016364-80l5mua2 52 23 reference reference NN cord-016364-80l5mua2 52 24 and and CC cord-016364-80l5mua2 52 25 integration integration NN cord-016364-80l5mua2 52 26 with with IN cord-016364-80l5mua2 52 27 Type type NN cord-016364-80l5mua2 52 28 I -PRON- PRP cord-016364-80l5mua2 52 29 loci locus NNS cord-016364-80l5mua2 52 30 . . . cord-016364-80l5mua2 53 1 Whereas whereas IN cord-016364-80l5mua2 53 2 the the DT cord-016364-80l5mua2 53 3 third third JJ cord-016364-80l5mua2 53 4 - - HYPH cord-016364-80l5mua2 53 5 generation generation NN cord-016364-80l5mua2 53 6 linkage linkage NN cord-016364-80l5mua2 53 7 map map NN cord-016364-80l5mua2 53 8 is be VBZ cord-016364-80l5mua2 53 9 composed compose VBN cord-016364-80l5mua2 53 10 entirely entirely RB cord-016364-80l5mua2 53 11 of of IN cord-016364-80l5mua2 53 12 STR STR NNP cord-016364-80l5mua2 53 13 loci locus NNS cord-016364-80l5mua2 53 14 , , , cord-016364-80l5mua2 53 15 the the DT cord-016364-80l5mua2 53 16 sequence sequence NN cord-016364-80l5mua2 53 17 homology homology NN cord-016364-80l5mua2 53 18 of of IN cord-016364-80l5mua2 53 19 extended extended JJ cord-016364-80l5mua2 53 20 genomic genomic JJ cord-016364-80l5mua2 53 21 regions region NNS cord-016364-80l5mua2 53 22 adjacent adjacent JJ cord-016364-80l5mua2 53 23 to to IN cord-016364-80l5mua2 53 24 the the DT cord-016364-80l5mua2 53 25 STR STR NNP cord-016364-80l5mua2 53 26 loci locus NNS cord-016364-80l5mua2 53 27 in in IN cord-016364-80l5mua2 53 28 the the DT cord-016364-80l5mua2 53 29 cat cat NN cord-016364-80l5mua2 53 30 2X 2x CD cord-016364-80l5mua2 53 31 whole whole JJ cord-016364-80l5mua2 53 32 genome genome NN cord-016364-80l5mua2 53 33 sequence sequence NN cord-016364-80l5mua2 53 34 , , , cord-016364-80l5mua2 53 35 17 17 CD cord-016364-80l5mua2 53 36 to to IN cord-016364-80l5mua2 53 37 the the DT cord-016364-80l5mua2 53 38 dog dog NN cord-016364-80l5mua2 53 39 's 's POS cord-016364-80l5mua2 53 40 homologous homologous JJ cord-016364-80l5mua2 53 41 region region NN cord-016364-80l5mua2 53 42 , , , cord-016364-80l5mua2 53 43 19 19 CD cord-016364-80l5mua2 53 44 has have VBZ cord-016364-80l5mua2 53 45 enabled enable VBN cord-016364-80l5mua2 53 46 us -PRON- PRP cord-016364-80l5mua2 53 47 to to TO cord-016364-80l5mua2 53 48 obtain obtain VB cord-016364-80l5mua2 53 49 identifiable identifiable JJ cord-016364-80l5mua2 53 50 orthologues orthologue NNS cord-016364-80l5mua2 53 51 in in IN cord-016364-80l5mua2 53 52 the the DT cord-016364-80l5mua2 53 53 canine canine JJ cord-016364-80l5mua2 53 54 and and CC cord-016364-80l5mua2 53 55 human human JJ cord-016364-80l5mua2 53 56 genome genome NN cord-016364-80l5mua2 53 57 sequences sequence NNS cord-016364-80l5mua2 53 58 for for IN cord-016364-80l5mua2 53 59 over over IN cord-016364-80l5mua2 53 60 95 95 CD cord-016364-80l5mua2 53 61 % % NN cord-016364-80l5mua2 53 62 of of IN cord-016364-80l5mua2 53 63 the the DT cord-016364-80l5mua2 53 64 STRs str NNS cord-016364-80l5mua2 53 65 . . . cord-016364-80l5mua2 54 1 Thus thus RB cord-016364-80l5mua2 54 2 , , , cord-016364-80l5mua2 54 3 practically practically RB cord-016364-80l5mua2 54 4 every every DT cord-016364-80l5mua2 54 5 STR str NN cord-016364-80l5mua2 54 6 acts act VBZ cord-016364-80l5mua2 54 7 as as IN cord-016364-80l5mua2 54 8 a a DT cord-016364-80l5mua2 54 9 " " `` cord-016364-80l5mua2 54 10 virtual virtual JJ cord-016364-80l5mua2 54 11 " " '' cord-016364-80l5mua2 54 12 Type type NN cord-016364-80l5mua2 54 13 1 1 CD cord-016364-80l5mua2 54 14 locus locus NN cord-016364-80l5mua2 54 15 , , , cord-016364-80l5mua2 54 16 with with IN cord-016364-80l5mua2 54 17 both both CC cord-016364-80l5mua2 54 18 comparative comparative JJ cord-016364-80l5mua2 54 19 anchoring anchoring NN cord-016364-80l5mua2 54 20 and and CC cord-016364-80l5mua2 54 21 linkage linkage NN cord-016364-80l5mua2 54 22 map map NN cord-016364-80l5mua2 54 23 utility utility NN cord-016364-80l5mua2 54 24 . . . cord-016364-80l5mua2 55 1 Combined combine VBN cord-016364-80l5mua2 55 2 with with IN cord-016364-80l5mua2 55 3 the the DT cord-016364-80l5mua2 55 4 cat cat NN cord-016364-80l5mua2 55 5 RH RH NNP cord-016364-80l5mua2 55 6 map map NN cord-016364-80l5mua2 55 7 , , , cord-016364-80l5mua2 55 8 these these DT cord-016364-80l5mua2 55 9 genomic genomic JJ cord-016364-80l5mua2 55 10 tools tool NNS cord-016364-80l5mua2 55 11 provide provide VBP cord-016364-80l5mua2 55 12 us -PRON- PRP cord-016364-80l5mua2 55 13 with with IN cord-016364-80l5mua2 55 14 the the DT cord-016364-80l5mua2 55 15 comparative comparative JJ cord-016364-80l5mua2 55 16 reference reference NN cord-016364-80l5mua2 55 17 to to IN cord-016364-80l5mua2 55 18 other other JJ cord-016364-80l5mua2 55 19 mammalian mammalian JJ cord-016364-80l5mua2 55 20 genomes genome NNS cord-016364-80l5mua2 55 21 critical critical JJ cord-016364-80l5mua2 55 22 for for IN cord-016364-80l5mua2 55 23 linkage linkage NN cord-016364-80l5mua2 55 24 and and CC cord-016364-80l5mua2 55 25 association association NN cord-016364-80l5mua2 55 26 mapping mapping NN cord-016364-80l5mua2 55 27 . . . cord-016364-80l5mua2 56 1 The the DT cord-016364-80l5mua2 56 2 domestic domestic JJ cord-016364-80l5mua2 56 3 cat cat NN cord-016364-80l5mua2 56 4 is be VBZ cord-016364-80l5mua2 56 5 one one CD cord-016364-80l5mua2 56 6 of of IN cord-016364-80l5mua2 56 7 26 26 CD cord-016364-80l5mua2 56 8 mammalian mammalian JJ cord-016364-80l5mua2 56 9 species specie NNS cord-016364-80l5mua2 56 10 endorsed endorse VBN cord-016364-80l5mua2 56 11 by by IN cord-016364-80l5mua2 56 12 the the DT cord-016364-80l5mua2 56 13 National National NNP cord-016364-80l5mua2 56 14 Human Human NNP cord-016364-80l5mua2 56 15 Genome Genome NNP cord-016364-80l5mua2 56 16 Research Research NNP cord-016364-80l5mua2 56 17 Institute Institute NNP cord-016364-80l5mua2 56 18 ( ( -LRB- cord-016364-80l5mua2 56 19 NHGRI NHGRI NNP cord-016364-80l5mua2 56 20 ) ) -RRB- cord-016364-80l5mua2 56 21 Human Human NNP cord-016364-80l5mua2 56 22 Genome Genome NNP cord-016364-80l5mua2 56 23 Annotation Annotation NNP cord-016364-80l5mua2 56 24 committee committee NN cord-016364-80l5mua2 56 25 for for IN cord-016364-80l5mua2 56 26 a a DT cord-016364-80l5mua2 56 27 " " `` cord-016364-80l5mua2 56 28 light light NN cord-016364-80l5mua2 56 29 " " '' cord-016364-80l5mua2 56 30 2-fold 2-fold CD cord-016364-80l5mua2 56 31 whole whole JJ cord-016364-80l5mua2 56 32 genome genome NN cord-016364-80l5mua2 56 33 sequence sequence NN cord-016364-80l5mua2 56 34 , , , cord-016364-80l5mua2 56 35 largely largely RB cord-016364-80l5mua2 56 36 to to TO cord-016364-80l5mua2 56 37 capture capture VB cord-016364-80l5mua2 56 38 the the DT cord-016364-80l5mua2 56 39 pattern pattern NN cord-016364-80l5mua2 56 40 of of IN cord-016364-80l5mua2 56 41 genome genome NN cord-016364-80l5mua2 56 42 variation variation NN cord-016364-80l5mua2 56 43 and and CC cord-016364-80l5mua2 56 44 divergence divergence NN cord-016364-80l5mua2 56 45 that that WDT cord-016364-80l5mua2 56 46 characterizes characterize VBZ cord-016364-80l5mua2 56 47 the the DT cord-016364-80l5mua2 56 48 mammalian mammalian JJ cord-016364-80l5mua2 56 49 radiations radiation NNS cord-016364-80l5mua2 56 50 ( ( -LRB- cord-016364-80l5mua2 56 51 http:// http:// NNP cord-016364-80l5mua2 56 52 www.hgsc.bcm.tmc.edu/projects/bovine/ www.hgsc.bcm.tmc.edu/projects/bovine/ NNP cord-016364-80l5mua2 56 53 , , , cord-016364-80l5mua2 56 54 http://www.broad.mit http://www.broad.mit ADD cord-016364-80l5mua2 56 55 . . . cord-016364-80l5mua2 57 1 edu edu NNP cord-016364-80l5mua2 57 2 / / SYM cord-016364-80l5mua2 57 3 mammals/ mammals/ CD cord-016364-80l5mua2 57 4 ) ) -RRB- cord-016364-80l5mua2 57 5 . . . cord-016364-80l5mua2 58 1 Although although IN cord-016364-80l5mua2 58 2 light light JJ cord-016364-80l5mua2 58 3 genome genome NN cord-016364-80l5mua2 58 4 coverage coverage NN cord-016364-80l5mua2 58 5 provides provide VBZ cord-016364-80l5mua2 58 6 limited limited JJ cord-016364-80l5mua2 58 7 sequence sequence NN cord-016364-80l5mua2 58 8 representation representation NN cord-016364-80l5mua2 58 9 , , , cord-016364-80l5mua2 58 10 ( ( -LRB- cord-016364-80l5mua2 58 11 ∼80 ∼80 NN cord-016364-80l5mua2 58 12 % % NN cord-016364-80l5mua2 58 13 ) ) -RRB- cord-016364-80l5mua2 58 14 , , , cord-016364-80l5mua2 58 15 20 20 CD cord-016364-80l5mua2 58 16 one one CD cord-016364-80l5mua2 58 17 of of IN cord-016364-80l5mua2 58 18 the the DT cord-016364-80l5mua2 58 19 rationales rationale NNS cord-016364-80l5mua2 58 20 for for IN cord-016364-80l5mua2 58 21 these these DT cord-016364-80l5mua2 58 22 light light JJ cord-016364-80l5mua2 58 23 genome genome NN cord-016364-80l5mua2 58 24 sequences sequence NNS cord-016364-80l5mua2 58 25 included include VBD cord-016364-80l5mua2 58 26 " " `` cord-016364-80l5mua2 58 27 enhancing enhance VBG cord-016364-80l5mua2 58 28 opportunities opportunity NNS cord-016364-80l5mua2 58 29 for for IN cord-016364-80l5mua2 58 30 research research NN cord-016364-80l5mua2 58 31 on on IN cord-016364-80l5mua2 58 32 species specie NNS cord-016364-80l5mua2 58 33 providing provide VBG cord-016364-80l5mua2 58 34 human human JJ cord-016364-80l5mua2 58 35 medical medical JJ cord-016364-80l5mua2 58 36 models model NNS cord-016364-80l5mua2 58 37 . . . cord-016364-80l5mua2 59 1 " " '' cord-016364-80l5mua2 60 1 The the DT cord-016364-80l5mua2 60 2 2-fold 2-fold CD cord-016364-80l5mua2 60 3 assembly assembly NN cord-016364-80l5mua2 60 4 of of IN cord-016364-80l5mua2 60 5 the the DT cord-016364-80l5mua2 60 6 domestic domestic JJ cord-016364-80l5mua2 60 7 cat cat NN cord-016364-80l5mua2 60 8 genome genome NN cord-016364-80l5mua2 60 9 has have VBZ cord-016364-80l5mua2 60 10 recently recently RB cord-016364-80l5mua2 60 11 been be VBN cord-016364-80l5mua2 60 12 completed complete VBN cord-016364-80l5mua2 60 13 for for IN cord-016364-80l5mua2 60 14 a a DT cord-016364-80l5mua2 60 15 female female JJ cord-016364-80l5mua2 60 16 Abyssinian abyssinian JJ cord-016364-80l5mua2 60 17 cat cat NN cord-016364-80l5mua2 60 18 , , , cord-016364-80l5mua2 60 19 " " '' cord-016364-80l5mua2 60 20 Cinnamon Cinnamon NNP cord-016364-80l5mua2 60 21 , , , cord-016364-80l5mua2 60 22 " " '' cord-016364-80l5mua2 60 23 17 17 CD cord-016364-80l5mua2 60 24 and and CC cord-016364-80l5mua2 60 25 a a DT cord-016364-80l5mua2 60 26 7X 7x CD cord-016364-80l5mua2 60 27 whole whole JJ cord-016364-80l5mua2 60 28 genome genome NN cord-016364-80l5mua2 60 29 sequencing sequencing NN cord-016364-80l5mua2 60 30 effort effort NN cord-016364-80l5mua2 60 31 is be VBZ cord-016364-80l5mua2 60 32 planned plan VBN cord-016364-80l5mua2 60 33 in in IN cord-016364-80l5mua2 60 34 the the DT cord-016364-80l5mua2 60 35 near near JJ cord-016364-80l5mua2 60 36 future future NN cord-016364-80l5mua2 60 37 . . . cord-016364-80l5mua2 61 1 A a DT cord-016364-80l5mua2 61 2 total total NN cord-016364-80l5mua2 61 3 of of IN cord-016364-80l5mua2 61 4 9,161,674 9,161,674 CD cord-016364-80l5mua2 61 5 reads read NNS cord-016364-80l5mua2 61 6 were be VBD cord-016364-80l5mua2 61 7 assembled assemble VBN cord-016364-80l5mua2 61 8 to to IN cord-016364-80l5mua2 61 9 817,956 817,956 CD cord-016364-80l5mua2 61 10 contigs contig NNS cord-016364-80l5mua2 61 11 , , , cord-016364-80l5mua2 61 12 covering cover VBG cord-016364-80l5mua2 61 13 1.642 1.642 CD cord-016364-80l5mua2 61 14 Gb Gb NNP cord-016364-80l5mua2 61 15 with with IN cord-016364-80l5mua2 61 16 an an DT cord-016364-80l5mua2 61 17 N50 n50 NN cord-016364-80l5mua2 61 18 ( ( -LRB- cord-016364-80l5mua2 61 19 i.e. i.e. FW cord-016364-80l5mua2 61 20 , , , cord-016364-80l5mua2 61 21 half half NN cord-016364-80l5mua2 61 22 of of IN cord-016364-80l5mua2 61 23 the the DT cord-016364-80l5mua2 61 24 sequenced sequence VBN cord-016364-80l5mua2 61 25 base base NN cord-016364-80l5mua2 61 26 pairs pair NNS cord-016364-80l5mua2 61 27 are be VBP cord-016364-80l5mua2 61 28 in in IN cord-016364-80l5mua2 61 29 contigs contigs NNP cord-016364-80l5mua2 61 30 < < NNP cord-016364-80l5mua2 61 31 N50 N50 NNP cord-016364-80l5mua2 61 32 ) ) -RRB- cord-016364-80l5mua2 61 33 contig contig NN cord-016364-80l5mua2 61 34 length length NN cord-016364-80l5mua2 61 35 of of IN cord-016364-80l5mua2 61 36 2378 2378 CD cord-016364-80l5mua2 61 37 bp bp NNP cord-016364-80l5mua2 61 38 . . . cord-016364-80l5mua2 62 1 Assembled assemble VBN cord-016364-80l5mua2 62 2 supercontigs supercontigs NNP cord-016364-80l5mua2 62 3 ( ( -LRB- cord-016364-80l5mua2 62 4 N n NN cord-016364-80l5mua2 62 5 = = SYM cord-016364-80l5mua2 62 6 217,790 217,790 CD cord-016364-80l5mua2 62 7 ) ) -RRB- cord-016364-80l5mua2 62 8 had have VBD cord-016364-80l5mua2 62 9 an an DT cord-016364-80l5mua2 62 10 N50 N50 NNP cord-016364-80l5mua2 62 11 length length NN cord-016364-80l5mua2 62 12 of of IN cord-016364-80l5mua2 62 13 117 117 CD cord-016364-80l5mua2 62 14 kb kb CD cord-016364-80l5mua2 62 15 17 17 CD cord-016364-80l5mua2 63 1 ( ( -LRB- cord-016364-80l5mua2 63 2 http:// http:// NNP cord-016364-80l5mua2 63 3 hosted host VBN cord-016364-80l5mua2 63 4 . . . cord-016364-80l5mua2 64 1 abcc.ncifcrf.gov/cgi-gin/gbrowse/cat/ abcc.ncifcrf.gov/cgi-gin/gbrowse/cat/ NNP cord-016364-80l5mua2 64 2 ) ) -RRB- cord-016364-80l5mua2 64 3 . . . cord-016364-80l5mua2 65 1 The the DT cord-016364-80l5mua2 65 2 estimated estimate VBN cord-016364-80l5mua2 65 3 size size NN cord-016364-80l5mua2 65 4 of of IN cord-016364-80l5mua2 65 5 the the DT cord-016364-80l5mua2 65 6 genome genome NN cord-016364-80l5mua2 65 7 was be VBD cord-016364-80l5mua2 65 8 2.7 2.7 CD cord-016364-80l5mua2 65 9 Gb Gb NNP cord-016364-80l5mua2 65 10 and and CC cord-016364-80l5mua2 65 11 the the DT cord-016364-80l5mua2 65 12 genome genome NN cord-016364-80l5mua2 65 13 coverage coverage NN cord-016364-80l5mua2 65 14 was be VBD cord-016364-80l5mua2 65 15 approximately approximately RB cord-016364-80l5mua2 65 16 2-fold 2-fold CD cord-016364-80l5mua2 65 17 , , , cord-016364-80l5mua2 65 18 predicting predict VBG cord-016364-80l5mua2 65 19 an an DT cord-016364-80l5mua2 65 20 average average JJ cord-016364-80l5mua2 65 21 inclusion inclusion NN cord-016364-80l5mua2 65 22 of of IN cord-016364-80l5mua2 65 23 80 80 CD cord-016364-80l5mua2 65 24 - - SYM cord-016364-80l5mua2 65 25 85 85 CD cord-016364-80l5mua2 65 26 % % NN cord-016364-80l5mua2 65 27 of of IN cord-016364-80l5mua2 65 28 the the DT cord-016364-80l5mua2 65 29 eukaryotic eukaryotic JJ cord-016364-80l5mua2 65 30 genome genome NN cord-016364-80l5mua2 65 31 sequence sequence NN cord-016364-80l5mua2 65 32 . . . cord-016364-80l5mua2 66 1 21 21 CD cord-016364-80l5mua2 66 2 Feline feline JJ cord-016364-80l5mua2 66 3 coding coding NN cord-016364-80l5mua2 66 4 genes gene NNS cord-016364-80l5mua2 66 5 were be VBD cord-016364-80l5mua2 66 6 identified identify VBN cord-016364-80l5mua2 66 7 using use VBG cord-016364-80l5mua2 66 8 a a DT cord-016364-80l5mua2 66 9 comparative comparative JJ cord-016364-80l5mua2 66 10 approach approach NN cord-016364-80l5mua2 66 11 based base VBN cord-016364-80l5mua2 66 12 upon upon IN cord-016364-80l5mua2 66 13 sequence sequence NN cord-016364-80l5mua2 66 14 homology homology NN cord-016364-80l5mua2 66 15 and and CC cord-016364-80l5mua2 66 16 syntenic syntenic NNP cord-016364-80l5mua2 66 17 orthology orthology NN cord-016364-80l5mua2 66 18 of of IN cord-016364-80l5mua2 66 19 neighboring neighbor VBG cord-016364-80l5mua2 66 20 gene gene NN cord-016364-80l5mua2 66 21 homologues homologue NNS cord-016364-80l5mua2 66 22 in in IN cord-016364-80l5mua2 66 23 the the DT cord-016364-80l5mua2 66 24 genomes genome NNS cord-016364-80l5mua2 66 25 of of IN cord-016364-80l5mua2 66 26 six six CD cord-016364-80l5mua2 66 27 index index NN cord-016364-80l5mua2 66 28 mammal mammal NN cord-016364-80l5mua2 66 29 species specie NNS cord-016364-80l5mua2 66 30 ( ( -LRB- cord-016364-80l5mua2 66 31 human human JJ cord-016364-80l5mua2 66 32 , , , cord-016364-80l5mua2 66 33 chimp chimp NN cord-016364-80l5mua2 66 34 , , , cord-016364-80l5mua2 66 35 mouse mouse NN cord-016364-80l5mua2 66 36 , , , cord-016364-80l5mua2 66 37 rat rat NN cord-016364-80l5mua2 66 38 , , , cord-016364-80l5mua2 66 39 cow cow NN cord-016364-80l5mua2 66 40 , , , cord-016364-80l5mua2 66 41 and and CC cord-016364-80l5mua2 66 42 dog dog NN cord-016364-80l5mua2 66 43 ) ) -RRB- cord-016364-80l5mua2 66 44 . . . cord-016364-80l5mua2 67 1 The the DT cord-016364-80l5mua2 67 2 results result NNS cord-016364-80l5mua2 67 3 revealed reveal VBD cord-016364-80l5mua2 67 4 nearly nearly RB cord-016364-80l5mua2 67 5 21,080 21,080 CD cord-016364-80l5mua2 67 6 feline feline JJ cord-016364-80l5mua2 67 7 genes gene NNS cord-016364-80l5mua2 67 8 plus plus CC cord-016364-80l5mua2 67 9 132,493 132,493 CD cord-016364-80l5mua2 67 10 conserved conserved JJ cord-016364-80l5mua2 67 11 sequence sequence NN cord-016364-80l5mua2 67 12 blocks block NNS cord-016364-80l5mua2 67 13 ( ( -LRB- cord-016364-80l5mua2 67 14 CSBs csb NNS cord-016364-80l5mua2 67 15 ) ) -RRB- cord-016364-80l5mua2 67 16 used use VBD cord-016364-80l5mua2 67 17 to to TO cord-016364-80l5mua2 67 18 build build VB cord-016364-80l5mua2 67 19 the the DT cord-016364-80l5mua2 67 20 gene gene NN cord-016364-80l5mua2 67 21 map map NN cord-016364-80l5mua2 67 22 , , , cord-016364-80l5mua2 67 23 17 17 CD cord-016364-80l5mua2 67 24 depending depend VBG cord-016364-80l5mua2 67 25 upon upon IN cord-016364-80l5mua2 67 26 the the DT cord-016364-80l5mua2 67 27 framework framework NN cord-016364-80l5mua2 67 28 RH RH NNP cord-016364-80l5mua2 67 29 map map NN cord-016364-80l5mua2 67 30 of of IN cord-016364-80l5mua2 67 31 1794 1794 CD cord-016364-80l5mua2 67 32 ordered order VBN cord-016364-80l5mua2 67 33 Type type NN cord-016364-80l5mua2 67 34 1 1 CD cord-016364-80l5mua2 67 35 markers marker NNS cord-016364-80l5mua2 67 36 . . . cord-016364-80l5mua2 68 1 8 8 CD cord-016364-80l5mua2 69 1 The the DT cord-016364-80l5mua2 69 2 2X 2x CD cord-016364-80l5mua2 69 3 feline feline JJ cord-016364-80l5mua2 69 4 genome genome NN cord-016364-80l5mua2 69 5 sequence sequence NN cord-016364-80l5mua2 69 6 detects detect VBZ cord-016364-80l5mua2 69 7 83 83 CD cord-016364-80l5mua2 69 8 % % NN cord-016364-80l5mua2 69 9 of of IN cord-016364-80l5mua2 69 10 human human JJ cord-016364-80l5mua2 69 11 genes gene NNS cord-016364-80l5mua2 69 12 , , , cord-016364-80l5mua2 69 13 89 89 CD cord-016364-80l5mua2 69 14 % % NN cord-016364-80l5mua2 69 15 of of IN cord-016364-80l5mua2 69 16 chimp chimp NN cord-016364-80l5mua2 69 17 or or CC cord-016364-80l5mua2 69 18 cattle cattle NNS cord-016364-80l5mua2 69 19 genes gene NNS cord-016364-80l5mua2 69 20 , , , cord-016364-80l5mua2 69 21 and and CC cord-016364-80l5mua2 69 22 92 92 CD cord-016364-80l5mua2 69 23 % % NN cord-016364-80l5mua2 69 24 of of IN cord-016364-80l5mua2 69 25 dog dog NN cord-016364-80l5mua2 69 26 genes gene NNS cord-016364-80l5mua2 69 27 based base VBN cord-016364-80l5mua2 69 28 upon upon IN cord-016364-80l5mua2 69 29 sequence sequence NN cord-016364-80l5mua2 69 30 identity identity NN cord-016364-80l5mua2 69 31 to to IN cord-016364-80l5mua2 69 32 approximately approximately RB cord-016364-80l5mua2 69 33 1000 1000 CD cord-016364-80l5mua2 69 34 bp bp NN cord-016364-80l5mua2 69 35 of of IN cord-016364-80l5mua2 69 36 reciprocal reciprocal JJ cord-016364-80l5mua2 69 37 base base NN cord-016364-80l5mua2 69 38 match match NN cord-016364-80l5mua2 69 39 17 17 CD cord-016364-80l5mua2 69 40 between between IN cord-016364-80l5mua2 69 41 the the DT cord-016364-80l5mua2 69 42 cat cat NN cord-016364-80l5mua2 69 43 sequence sequence NN cord-016364-80l5mua2 69 44 and and CC cord-016364-80l5mua2 69 45 the the DT cord-016364-80l5mua2 69 46 genome genome NN cord-016364-80l5mua2 69 47 sequence sequence NN cord-016364-80l5mua2 69 48 of of IN cord-016364-80l5mua2 69 49 the the DT cord-016364-80l5mua2 69 50 six six CD cord-016364-80l5mua2 69 51 index index NN cord-016364-80l5mua2 69 52 mammals mammal NNS cord-016364-80l5mua2 69 53 . . . cord-016364-80l5mua2 70 1 A a DT cord-016364-80l5mua2 70 2 genome genome NN cord-016364-80l5mua2 70 3 browser browser NN cord-016364-80l5mua2 70 4 has have VBZ cord-016364-80l5mua2 70 5 been be VBN cord-016364-80l5mua2 70 6 developed develop VBN cord-016364-80l5mua2 70 7 from from IN cord-016364-80l5mua2 70 8 the the DT cord-016364-80l5mua2 70 9 cat cat NN cord-016364-80l5mua2 70 10 assembly assembly NNP cord-016364-80l5mua2 70 11 , , , cord-016364-80l5mua2 70 12 named name VBN cord-016364-80l5mua2 70 13 Genome Genome NNP cord-016364-80l5mua2 70 14 Annotation Annotation NNP cord-016364-80l5mua2 70 15 Region Region NNP cord-016364-80l5mua2 70 16 FIELD FIELD NNP cord-016364-80l5mua2 70 17 ( ( -LRB- cord-016364-80l5mua2 70 18 GARFIELD GARFIELD NNP cord-016364-80l5mua2 70 19 ) ) -RRB- cord-016364-80l5mua2 70 20 , , , cord-016364-80l5mua2 70 21 which which WDT cord-016364-80l5mua2 70 22 provides provide VBZ cord-016364-80l5mua2 70 23 a a DT cord-016364-80l5mua2 70 24 physical physical JJ cord-016364-80l5mua2 70 25 map map NN cord-016364-80l5mua2 70 26 of of IN cord-016364-80l5mua2 70 27 the the DT cord-016364-80l5mua2 70 28 18 18 CD cord-016364-80l5mua2 70 29 autosomes autosome NNS cord-016364-80l5mua2 70 30 and and CC cord-016364-80l5mua2 70 31 the the DT cord-016364-80l5mua2 70 32 X x NN cord-016364-80l5mua2 70 33 chromosome chromosome NN cord-016364-80l5mua2 70 34 , , , cord-016364-80l5mua2 70 35 which which WDT cord-016364-80l5mua2 70 36 can can MD cord-016364-80l5mua2 70 37 be be VB cord-016364-80l5mua2 70 38 inspected inspect VBN cord-016364-80l5mua2 70 39 for for IN cord-016364-80l5mua2 70 40 sequence sequence NN cord-016364-80l5mua2 70 41 representation representation NN cord-016364-80l5mua2 70 42 , , , cord-016364-80l5mua2 70 43 including include VBG cord-016364-80l5mua2 70 44 genes gene NNS cord-016364-80l5mua2 70 45 and and CC cord-016364-80l5mua2 70 46 the the DT cord-016364-80l5mua2 70 47 proportion proportion NN cord-016364-80l5mua2 70 48 of of IN cord-016364-80l5mua2 70 49 that that DT cord-016364-80l5mua2 70 50 gene gene NN cord-016364-80l5mua2 70 51 available available JJ cord-016364-80l5mua2 70 52 in in IN cord-016364-80l5mua2 70 53 the the DT cord-016364-80l5mua2 70 54 2X 2x CD cord-016364-80l5mua2 70 55 cover cover NN cord-016364-80l5mua2 70 56 , , , cord-016364-80l5mua2 70 57 single single JJ cord-016364-80l5mua2 70 58 nucleotide nucleotide JJ cord-016364-80l5mua2 70 59 polymorphisms polymorphism NNS cord-016364-80l5mua2 70 60 ( ( -LRB- cord-016364-80l5mua2 70 61 SNPs SNPs NNP cord-016364-80l5mua2 70 62 ) ) -RRB- cord-016364-80l5mua2 70 63 , , , cord-016364-80l5mua2 70 64 and and CC cord-016364-80l5mua2 70 65 STRs STRs NNPS cord-016364-80l5mua2 70 66 , , , cord-016364-80l5mua2 70 67 which which WDT cord-016364-80l5mua2 70 68 can can MD cord-016364-80l5mua2 70 69 be be VB cord-016364-80l5mua2 70 70 used use VBN cord-016364-80l5mua2 70 71 in in IN cord-016364-80l5mua2 70 72 linkage linkage NN cord-016364-80l5mua2 70 73 and and CC cord-016364-80l5mua2 70 74 association association NN cord-016364-80l5mua2 70 75 mapping mapping NN cord-016364-80l5mua2 70 76 , , , cord-016364-80l5mua2 70 77 and and CC cord-016364-80l5mua2 70 78 other other JJ cord-016364-80l5mua2 70 79 genome genome NN cord-016364-80l5mua2 70 80 features feature NNS cord-016364-80l5mua2 70 81 ( ( -LRB- cord-016364-80l5mua2 70 82 http://ccr.cancer.gov/ http://ccr.cancer.gov/ NNP cord-016364-80l5mua2 70 83 labs lab NNS cord-016364-80l5mua2 70 84 / / SYM cord-016364-80l5mua2 70 85 lab lab NN cord-016364-80l5mua2 70 86 ) ) -RRB- cord-016364-80l5mua2 70 87 . . . cord-016364-80l5mua2 71 1 Figure figure NN cord-016364-80l5mua2 71 2 _SP cord-016364-80l5mua2 71 3 A a DT cord-016364-80l5mua2 71 4 total total NN cord-016364-80l5mua2 71 5 of of IN cord-016364-80l5mua2 71 6 421,000 421,000 CD cord-016364-80l5mua2 71 7 SNP SNP NNP cord-016364-80l5mua2 71 8 variants variant NNS cord-016364-80l5mua2 71 9 were be VBD cord-016364-80l5mua2 71 10 identified identify VBN cord-016364-80l5mua2 71 11 in in IN cord-016364-80l5mua2 71 12 Cinnamon Cinnamon NNP cord-016364-80l5mua2 71 13 's 's POS cord-016364-80l5mua2 71 14 sequence sequence NN cord-016364-80l5mua2 71 15 , , , cord-016364-80l5mua2 71 16 representing represent VBG cord-016364-80l5mua2 71 17 an an DT cord-016364-80l5mua2 71 18 incidence incidence NN cord-016364-80l5mua2 71 19 of of IN cord-016364-80l5mua2 71 20 1/600 1/600 CD cord-016364-80l5mua2 71 21 bp bp NNP cord-016364-80l5mua2 71 22 . . . cord-016364-80l5mua2 72 1 17 17 CD cord-016364-80l5mua2 73 1 Approximately approximately RB cord-016364-80l5mua2 73 2 43 43 CD cord-016364-80l5mua2 73 3 % % NN cord-016364-80l5mua2 73 4 of of IN cord-016364-80l5mua2 73 5 Cinnamon Cinnamon NNP cord-016364-80l5mua2 73 6 's 's POS cord-016364-80l5mua2 73 7 genome genome NN cord-016364-80l5mua2 73 8 was be VBD cord-016364-80l5mua2 73 9 heterozygous heterozygous JJ cord-016364-80l5mua2 73 10 and and CC cord-016364-80l5mua2 73 11 57 57 CD cord-016364-80l5mua2 73 12 % % NN cord-016364-80l5mua2 73 13 homozygous homozygous JJ cord-016364-80l5mua2 73 14 , , , cord-016364-80l5mua2 73 15 which which WDT cord-016364-80l5mua2 73 16 was be VBD cord-016364-80l5mua2 73 17 not not RB cord-016364-80l5mua2 73 18 unexpected unexpected JJ cord-016364-80l5mua2 73 19 in in IN cord-016364-80l5mua2 73 20 a a DT cord-016364-80l5mua2 73 21 breed breed NN cord-016364-80l5mua2 73 22 cat cat NN cord-016364-80l5mua2 73 23 that that WDT cord-016364-80l5mua2 73 24 is be VBZ cord-016364-80l5mua2 73 25 also also RB cord-016364-80l5mua2 73 26 the the DT cord-016364-80l5mua2 73 27 member member NN cord-016364-80l5mua2 73 28 of of IN cord-016364-80l5mua2 73 29 a a DT cord-016364-80l5mua2 73 30 highly highly RB cord-016364-80l5mua2 73 31 inbred inbred JJ cord-016364-80l5mua2 73 32 pedigree pedigree NN cord-016364-80l5mua2 73 33 for for IN cord-016364-80l5mua2 73 34 retinal retinal JJ cord-016364-80l5mua2 73 35 atrophy atrophy NN cord-016364-80l5mua2 73 36 . . . cord-016364-80l5mua2 74 1 17 17 CD cord-016364-80l5mua2 74 2 , , , cord-016364-80l5mua2 74 3 22 22 CD cord-016364-80l5mua2 74 4 Long long JJ cord-016364-80l5mua2 74 5 stretches stretch NNS cord-016364-80l5mua2 74 6 of of IN cord-016364-80l5mua2 74 7 alternating alternate VBG cord-016364-80l5mua2 74 8 homozygous homozygous JJ cord-016364-80l5mua2 74 9 and and CC cord-016364-80l5mua2 74 10 heterozygous heterozygous JJ cord-016364-80l5mua2 74 11 segments segment NNS cord-016364-80l5mua2 74 12 were be VBD cord-016364-80l5mua2 74 13 observed observe VBN cord-016364-80l5mua2 74 14 ( ( -LRB- cord-016364-80l5mua2 74 15 Figure figure NN cord-016364-80l5mua2 74 16 25 25 CD cord-016364-80l5mua2 74 17 -3 -3 NNP cord-016364-80l5mua2 74 18 ) ) -RRB- cord-016364-80l5mua2 74 19 , , , cord-016364-80l5mua2 74 20 which which WDT cord-016364-80l5mua2 74 21 represent represent VBP cord-016364-80l5mua2 74 22 the the DT cord-016364-80l5mua2 74 23 consequences consequence NNS cord-016364-80l5mua2 74 24 of of IN cord-016364-80l5mua2 74 25 close close JJ cord-016364-80l5mua2 74 26 inbreeding inbreeding NN cord-016364-80l5mua2 74 27 during during IN cord-016364-80l5mua2 74 28 the the DT cord-016364-80l5mua2 74 29 domestication domestication NN cord-016364-80l5mua2 74 30 process process NN cord-016364-80l5mua2 74 31 , , , cord-016364-80l5mua2 74 32 and and CC cord-016364-80l5mua2 74 33 the the DT cord-016364-80l5mua2 74 34 more more RBR cord-016364-80l5mua2 74 35 recent recent JJ cord-016364-80l5mua2 74 36 generation generation NN cord-016364-80l5mua2 74 37 of of IN cord-016364-80l5mua2 74 38 fancy fancy JJ cord-016364-80l5mua2 74 39 breeds breed NNS cord-016364-80l5mua2 74 40 and and CC cord-016364-80l5mua2 74 41 inbred inbred JJ cord-016364-80l5mua2 74 42 disease disease NN cord-016364-80l5mua2 74 43 pedigree pedigree NN cord-016364-80l5mua2 74 44 . . . cord-016364-80l5mua2 75 1 22 22 CD cord-016364-80l5mua2 75 2 Similar similar JJ cord-016364-80l5mua2 75 3 patches patch NNS cord-016364-80l5mua2 75 4 of of IN cord-016364-80l5mua2 75 5 homozygous homozygous JJ cord-016364-80l5mua2 75 6 / / SYM cord-016364-80l5mua2 75 7 heterozygous heterozygous JJ cord-016364-80l5mua2 75 8 segments segment NNS cord-016364-80l5mua2 75 9 were be VBD cord-016364-80l5mua2 75 10 observed observe VBN cord-016364-80l5mua2 75 11 in in IN cord-016364-80l5mua2 75 12 the the DT cord-016364-80l5mua2 75 13 recently recently RB cord-016364-80l5mua2 75 14 released release VBN cord-016364-80l5mua2 75 15 whole whole JJ cord-016364-80l5mua2 75 16 genome genome NN cord-016364-80l5mua2 75 17 sequence sequence NN cord-016364-80l5mua2 75 18 of of IN cord-016364-80l5mua2 75 19 the the DT cord-016364-80l5mua2 75 20 dog dog NN cord-016364-80l5mua2 75 21 . . . cord-016364-80l5mua2 76 1 19 19 CD cord-016364-80l5mua2 77 1 The the DT cord-016364-80l5mua2 77 2 length length NN cord-016364-80l5mua2 77 3 of of IN cord-016364-80l5mua2 77 4 the the DT cord-016364-80l5mua2 77 5 segments segment NNS cord-016364-80l5mua2 77 6 is be VBZ cord-016364-80l5mua2 77 7 influenced influence VBN cord-016364-80l5mua2 77 8 by by IN cord-016364-80l5mua2 77 9 breedspecifi breedspecifi NNP cord-016364-80l5mua2 77 10 c c NNP cord-016364-80l5mua2 77 11 history history NN cord-016364-80l5mua2 77 12 including include VBG cord-016364-80l5mua2 77 13 effective effective JJ cord-016364-80l5mua2 77 14 population population NN cord-016364-80l5mua2 77 15 sizes size NNS cord-016364-80l5mua2 77 16 , , , cord-016364-80l5mua2 77 17 use use NN cord-016364-80l5mua2 77 18 of of IN cord-016364-80l5mua2 77 19 popular popular JJ cord-016364-80l5mua2 77 20 sires sire NNS cord-016364-80l5mua2 77 21 , , , cord-016364-80l5mua2 77 22 and and CC cord-016364-80l5mua2 77 23 population population NN cord-016364-80l5mua2 77 24 bottlenecks bottleneck NNS cord-016364-80l5mua2 77 25 . . . cord-016364-80l5mua2 78 1 23 23 CD cord-016364-80l5mua2 78 2 , , , cord-016364-80l5mua2 78 3 24 24 CD cord-016364-80l5mua2 78 4 Linkage linkage NN cord-016364-80l5mua2 78 5 disequilibrium disequilibrium NN cord-016364-80l5mua2 78 6 ( ( -LRB- cord-016364-80l5mua2 78 7 LD LD NNP cord-016364-80l5mua2 78 8 ) ) -RRB- cord-016364-80l5mua2 78 9 mapping mapping NN cord-016364-80l5mua2 78 10 has have VBZ cord-016364-80l5mua2 78 11 recently recently RB cord-016364-80l5mua2 78 12 emerged emerge VBN cord-016364-80l5mua2 78 13 as as IN cord-016364-80l5mua2 78 14 a a DT cord-016364-80l5mua2 78 15 powerful powerful JJ cord-016364-80l5mua2 78 16 approach approach NN cord-016364-80l5mua2 78 17 in in IN cord-016364-80l5mua2 78 18 humans human NNS cord-016364-80l5mua2 78 19 for for IN cord-016364-80l5mua2 78 20 association association NN cord-016364-80l5mua2 78 21 mapping mapping NN cord-016364-80l5mua2 78 22 . . . cord-016364-80l5mua2 79 1 25 25 CD cord-016364-80l5mua2 79 2 Long long JJ cord-016364-80l5mua2 79 3 stretches stretch NNS cord-016364-80l5mua2 79 4 of of IN cord-016364-80l5mua2 79 5 linkage linkage NN cord-016364-80l5mua2 79 6 disequilibrium disequilibrium NN cord-016364-80l5mua2 79 7 in in IN cord-016364-80l5mua2 79 8 the the DT cord-016364-80l5mua2 79 9 target target NN cord-016364-80l5mua2 79 10 population population NN cord-016364-80l5mua2 79 11 greatly greatly RB cord-016364-80l5mua2 79 12 facilitate facilitate VBP cord-016364-80l5mua2 79 13 the the DT cord-016364-80l5mua2 79 14 success success NN cord-016364-80l5mua2 79 15 of of IN cord-016364-80l5mua2 79 16 the the DT cord-016364-80l5mua2 79 17 strategy strategy NN cord-016364-80l5mua2 79 18 and and CC cord-016364-80l5mua2 79 19 decrease decrease VB cord-016364-80l5mua2 79 20 the the DT cord-016364-80l5mua2 79 21 number number NN cord-016364-80l5mua2 79 22 of of IN cord-016364-80l5mua2 79 23 markers marker NNS cord-016364-80l5mua2 79 24 required require VBN cord-016364-80l5mua2 79 25 for for IN cord-016364-80l5mua2 79 26 analysis analysis NN cord-016364-80l5mua2 79 27 . . . cord-016364-80l5mua2 80 1 25 25 CD cord-016364-80l5mua2 81 1 The the DT cord-016364-80l5mua2 81 2 extended extended JJ cord-016364-80l5mua2 81 3 LDs LDs NNP cord-016364-80l5mua2 81 4 observed observe VBD cord-016364-80l5mua2 81 5 in in IN cord-016364-80l5mua2 81 6 dog dog NN cord-016364-80l5mua2 81 7 breeds breed NNS cord-016364-80l5mua2 81 8 , , , cord-016364-80l5mua2 81 9 up up IN cord-016364-80l5mua2 81 10 to to IN cord-016364-80l5mua2 81 11 one one CD cord-016364-80l5mua2 81 12 hundred hundred CD cord-016364-80l5mua2 81 13 times time NNS cord-016364-80l5mua2 81 14 the the DT cord-016364-80l5mua2 81 15 length length NN cord-016364-80l5mua2 81 16 observed observe VBN cord-016364-80l5mua2 81 17 in in IN cord-016364-80l5mua2 81 18 human human JJ cord-016364-80l5mua2 81 19 populations population NNS cord-016364-80l5mua2 81 20 , , , cord-016364-80l5mua2 81 21 26 26 CD cord-016364-80l5mua2 81 22 is be VBZ cord-016364-80l5mua2 81 23 proving prove VBG cord-016364-80l5mua2 81 24 to to TO cord-016364-80l5mua2 81 25 be be VB cord-016364-80l5mua2 81 26 a a DT cord-016364-80l5mua2 81 27 powerful powerful JJ cord-016364-80l5mua2 81 28 mapping mapping NN cord-016364-80l5mua2 81 29 strategy strategy NN cord-016364-80l5mua2 81 30 for for IN cord-016364-80l5mua2 81 31 identification identification NN cord-016364-80l5mua2 81 32 of of IN cord-016364-80l5mua2 81 33 genes gene NNS cord-016364-80l5mua2 81 34 associated associate VBN cord-016364-80l5mua2 81 35 with with IN cord-016364-80l5mua2 81 36 breedspecifi breedspecifi NNP cord-016364-80l5mua2 81 37 c c NN cord-016364-80l5mua2 81 38 phenotypes phenotype NNS cord-016364-80l5mua2 81 39 , , , cord-016364-80l5mua2 81 40 27 27 CD cord-016364-80l5mua2 81 41 including include VBG cord-016364-80l5mua2 81 42 hereditary hereditary JJ cord-016364-80l5mua2 81 43 pathologies pathology NNS cord-016364-80l5mua2 81 44 . . . cord-016364-80l5mua2 82 1 28 28 CD cord-016364-80l5mua2 82 2 , , , cord-016364-80l5mua2 82 3 29 29 CD cord-016364-80l5mua2 83 1 The the DT cord-016364-80l5mua2 83 2 potential potential NN cord-016364-80l5mua2 83 3 of of IN cord-016364-80l5mua2 83 4 this this DT cord-016364-80l5mua2 83 5 mapping mapping NN cord-016364-80l5mua2 83 6 approach approach NN cord-016364-80l5mua2 83 7 in in IN cord-016364-80l5mua2 83 8 cat cat NN cord-016364-80l5mua2 83 9 breeds breed NNS cord-016364-80l5mua2 83 10 was be VBD cord-016364-80l5mua2 83 11 evaluated evaluate VBN cord-016364-80l5mua2 83 12 by by IN cord-016364-80l5mua2 83 13 examining examine VBG cord-016364-80l5mua2 83 14 breed breed VB cord-016364-80l5mua2 83 15 - - HYPH cord-016364-80l5mua2 83 16 specific specific JJ cord-016364-80l5mua2 83 17 patterns pattern NNS cord-016364-80l5mua2 83 18 of of IN cord-016364-80l5mua2 83 19 common common JJ cord-016364-80l5mua2 83 20 segment segment NN cord-016364-80l5mua2 83 21 homozygosity homozygosity NN cord-016364-80l5mua2 83 22 in in IN cord-016364-80l5mua2 83 23 24 24 CD cord-016364-80l5mua2 83 24 Cat Cat NNP cord-016364-80l5mua2 83 25 Fancier Fancier NNP cord-016364-80l5mua2 83 26 Association Association NNP cord-016364-80l5mua2 83 27 ( ( -LRB- cord-016364-80l5mua2 83 28 CFA CFA NNP cord-016364-80l5mua2 83 29 ) ) -RRB- cord-016364-80l5mua2 83 30 ( ( -LRB- cord-016364-80l5mua2 83 31 http://www.cfainc.org http://www.cfainc.org NN cord-016364-80l5mua2 83 32 ) ) -RRB- cord-016364-80l5mua2 83 33 breeds breed NNS cord-016364-80l5mua2 83 34 . . . cord-016364-80l5mua2 84 1 17 17 CD cord-016364-80l5mua2 85 1 The the DT cord-016364-80l5mua2 85 2 level level NN cord-016364-80l5mua2 85 3 of of IN cord-016364-80l5mua2 85 4 homozygosity homozygosity NN cord-016364-80l5mua2 85 5 refl refl NNP cord-016364-80l5mua2 85 6 ected ecte VBN cord-016364-80l5mua2 85 7 in in IN cord-016364-80l5mua2 85 8 a a DT cord-016364-80l5mua2 85 9 group group NN cord-016364-80l5mua2 85 10 of of IN cord-016364-80l5mua2 85 11 665 665 CD cord-016364-80l5mua2 85 12 SNPs SNPs NNPS cord-016364-80l5mua2 85 13 was be VBD cord-016364-80l5mua2 85 14 roughly roughly RB cord-016364-80l5mua2 85 15 half half NN cord-016364-80l5mua2 85 16 that that WDT cord-016364-80l5mua2 85 17 seen see VBN cord-016364-80l5mua2 85 18 in in IN cord-016364-80l5mua2 85 19 dogs dog NNS cord-016364-80l5mua2 85 20 , , , cord-016364-80l5mua2 85 21 26 26 CD cord-016364-80l5mua2 85 22 likely likely RB cord-016364-80l5mua2 85 23 reflecting reflect VBG cord-016364-80l5mua2 85 24 a a DT cord-016364-80l5mua2 85 25 more more RBR cord-016364-80l5mua2 85 26 extensive extensive JJ cord-016364-80l5mua2 85 27 recent recent JJ cord-016364-80l5mua2 85 28 inbreeding inbreeding NN cord-016364-80l5mua2 85 29 within within IN cord-016364-80l5mua2 85 30 Heterozygosity Heterozygosity NNP cord-016364-80l5mua2 85 31 across across IN cord-016364-80l5mua2 85 32 Cinnamon Cinnamon NNP cord-016364-80l5mua2 85 33 's 's POS cord-016364-80l5mua2 85 34 chromosomes chromosome NNS cord-016364-80l5mua2 85 35 is be VBZ cord-016364-80l5mua2 85 36 represented represent VBN cord-016364-80l5mua2 85 37 in in IN cord-016364-80l5mua2 85 38 nonoverlapping nonoverlappe VBG cord-016364-80l5mua2 85 39 windows window NNS cord-016364-80l5mua2 85 40 of of IN cord-016364-80l5mua2 85 41 100 100 CD cord-016364-80l5mua2 85 42 kb kb NNS cord-016364-80l5mua2 85 43 . . . cord-016364-80l5mua2 86 1 Black black JJ cord-016364-80l5mua2 86 2 represents represent VBZ cord-016364-80l5mua2 86 3 regions region NNS cord-016364-80l5mua2 86 4 with with IN cord-016364-80l5mua2 86 5 more more JJR cord-016364-80l5mua2 86 6 than than IN cord-016364-80l5mua2 86 7 two two CD cord-016364-80l5mua2 86 8 SNPs snp NNS cord-016364-80l5mua2 86 9 per per IN cord-016364-80l5mua2 86 10 100 100 CD cord-016364-80l5mua2 86 11 kb kb NNP cord-016364-80l5mua2 86 12 while while IN cord-016364-80l5mua2 86 13 gray gray JJ cord-016364-80l5mua2 86 14 represents represent VBZ cord-016364-80l5mua2 86 15 the the DT cord-016364-80l5mua2 86 16 homozygous homozygous JJ cord-016364-80l5mua2 86 17 region region NN cord-016364-80l5mua2 86 18 ( ( -LRB- cord-016364-80l5mua2 86 19 less less JJR cord-016364-80l5mua2 86 20 than than IN cord-016364-80l5mua2 86 21 two two CD cord-016364-80l5mua2 86 22 SNP SNP NNP cord-016364-80l5mua2 86 23 , , , cord-016364-80l5mua2 86 24 0/100 0/100 CD cord-016364-80l5mua2 86 25 kb kb NNP cord-016364-80l5mua2 86 26 ) ) -RRB- cord-016364-80l5mua2 86 27 . . . cord-016364-80l5mua2 87 1 White White NNP cord-016364-80l5mua2 87 2 represents represent VBZ cord-016364-80l5mua2 87 3 gaps gap NNS cord-016364-80l5mua2 87 4 in in IN cord-016364-80l5mua2 87 5 the the DT cord-016364-80l5mua2 87 6 chromosome chromosome NN cord-016364-80l5mua2 87 7 assembly assembly NN cord-016364-80l5mua2 87 8 . . . cord-016364-80l5mua2 88 1 dog dog NN cord-016364-80l5mua2 88 2 versus versus IN cord-016364-80l5mua2 88 3 cat cat NN cord-016364-80l5mua2 88 4 breeds breed NNS cord-016364-80l5mua2 88 5 . . . cord-016364-80l5mua2 89 1 30 30 CD cord-016364-80l5mua2 90 1 This this DT cord-016364-80l5mua2 90 2 level level NN cord-016364-80l5mua2 90 3 of of IN cord-016364-80l5mua2 90 4 homozygosity homozygosity NN cord-016364-80l5mua2 90 5 was be VBD cord-016364-80l5mua2 90 6 used use VBN cord-016364-80l5mua2 90 7 to to TO cord-016364-80l5mua2 90 8 estimate estimate VB cord-016364-80l5mua2 90 9 19 19 CD cord-016364-80l5mua2 90 10 that that IN cord-016364-80l5mua2 90 11 some some RB cord-016364-80l5mua2 90 12 45,000 45,000 CD cord-016364-80l5mua2 90 13 equivalently equivalently RB cord-016364-80l5mua2 90 14 spaced space VBN cord-016364-80l5mua2 90 15 SNP SNP NNP cord-016364-80l5mua2 90 16 variants variant NNS cord-016364-80l5mua2 90 17 would would MD cord-016364-80l5mua2 90 18 be be VB cord-016364-80l5mua2 90 19 required require VBN cord-016364-80l5mua2 90 20 for for IN cord-016364-80l5mua2 90 21 a a DT cord-016364-80l5mua2 90 22 linkage linkage NN cord-016364-80l5mua2 90 23 disequilibrium disequilibrium NN cord-016364-80l5mua2 90 24 / / SYM cord-016364-80l5mua2 90 25 haplotype haplotype NN cord-016364-80l5mua2 90 26 - - HYPH cord-016364-80l5mua2 90 27 based base VBN cord-016364-80l5mua2 90 28 association association NN cord-016364-80l5mua2 90 29 genome genome NN cord-016364-80l5mua2 90 30 search search NN cord-016364-80l5mua2 90 31 of of IN cord-016364-80l5mua2 90 32 a a DT cord-016364-80l5mua2 90 33 complex complex JJ cord-016364-80l5mua2 90 34 heritable heritable JJ cord-016364-80l5mua2 90 35 disease disease NN cord-016364-80l5mua2 90 36 within within IN cord-016364-80l5mua2 90 37 cat cat NN cord-016364-80l5mua2 90 38 breeds breed NNS cord-016364-80l5mua2 90 39 . . . cord-016364-80l5mua2 91 1 Recently recently RB cord-016364-80l5mua2 91 2 , , , cord-016364-80l5mua2 91 3 tyrosinase tyrosinase NN cord-016364-80l5mua2 91 4 - - HYPH cord-016364-80l5mua2 91 5 related relate VBN cord-016364-80l5mua2 91 6 protein protein NN cord-016364-80l5mua2 91 7 1 1 CD cord-016364-80l5mua2 91 8 ( ( -LRB- cord-016364-80l5mua2 91 9 TYRP1 TYRP1 NNP cord-016364-80l5mua2 91 10 ) ) -RRB- cord-016364-80l5mua2 91 11 , , , cord-016364-80l5mua2 91 12 one one CD cord-016364-80l5mua2 91 13 of of IN cord-016364-80l5mua2 91 14 the the DT cord-016364-80l5mua2 91 15 key key JJ cord-016364-80l5mua2 91 16 enzymes enzyme NNS cord-016364-80l5mua2 91 17 in in IN cord-016364-80l5mua2 91 18 the the DT cord-016364-80l5mua2 91 19 melanogenic melanogenic NNP cord-016364-80l5mua2 91 20 pathway pathway NNP cord-016364-80l5mua2 91 21 , , , cord-016364-80l5mua2 91 22 was be VBD cord-016364-80l5mua2 91 23 linked link VBN cord-016364-80l5mua2 91 24 to to IN cord-016364-80l5mua2 91 25 two two CD cord-016364-80l5mua2 91 26 coat coat NN cord-016364-80l5mua2 91 27 color color NN cord-016364-80l5mua2 91 28 variants variant NNS cord-016364-80l5mua2 91 29 in in IN cord-016364-80l5mua2 91 30 the the DT cord-016364-80l5mua2 91 31 cat cat NN cord-016364-80l5mua2 91 32 by by IN cord-016364-80l5mua2 91 33 association association NN cord-016364-80l5mua2 91 34 mapping mapping NN cord-016364-80l5mua2 91 35 in in IN cord-016364-80l5mua2 91 36 38 38 CD cord-016364-80l5mua2 91 37 cat cat NN cord-016364-80l5mua2 91 38 breeds breed NNS cord-016364-80l5mua2 91 39 due due JJ cord-016364-80l5mua2 91 40 to to IN cord-016364-80l5mua2 91 41 extensive extensive JJ cord-016364-80l5mua2 91 42 LD LD NNP cord-016364-80l5mua2 91 43 . . . cord-016364-80l5mua2 92 1 31 31 CD cord-016364-80l5mua2 93 1 Two two CD cord-016364-80l5mua2 93 2 DNA dna NN cord-016364-80l5mua2 93 3 polymorphisms polymorphism NNS cord-016364-80l5mua2 93 4 in in IN cord-016364-80l5mua2 93 5 TYRP1 tyrp1 NN cord-016364-80l5mua2 93 6 , , , cord-016364-80l5mua2 93 7 an an DT cord-016364-80l5mua2 93 8 A3 A3 NNP cord-016364-80l5mua2 93 9 G g NN cord-016364-80l5mua2 93 10 substitution substitution NN cord-016364-80l5mua2 93 11 in in IN cord-016364-80l5mua2 93 12 the the DT cord-016364-80l5mua2 93 13 signal signal NN cord-016364-80l5mua2 93 14 peptide peptide NN cord-016364-80l5mua2 93 15 and and CC cord-016364-80l5mua2 93 16 an an DT cord-016364-80l5mua2 93 17 in in IN cord-016364-80l5mua2 93 18 - - HYPH cord-016364-80l5mua2 93 19 frame frame NN cord-016364-80l5mua2 93 20 insertion insertion NN cord-016364-80l5mua2 94 1 TYRP1 TYRP1 NNP cord-016364-80l5mua2 94 2 - - : cord-016364-80l5mua2 94 3 421ins17/18 421ins17/18 CD cord-016364-80l5mua2 94 4 , , , cord-016364-80l5mua2 94 5 were be VBD cord-016364-80l5mua2 94 6 associated associate VBN cord-016364-80l5mua2 94 7 with with IN cord-016364-80l5mua2 94 8 the the DT cord-016364-80l5mua2 94 9 chocolate chocolate NN cord-016364-80l5mua2 94 10 ( ( -LRB- cord-016364-80l5mua2 94 11 b b NN cord-016364-80l5mua2 94 12 ) ) -RRB- cord-016364-80l5mua2 94 13 allele allele NN cord-016364-80l5mua2 94 14 . . . cord-016364-80l5mua2 95 1 A a DT cord-016364-80l5mua2 95 2 premature premature JJ cord-016364-80l5mua2 95 3 UAG UAG NNP cord-016364-80l5mua2 95 4 stop stop NN cord-016364-80l5mua2 95 5 codon codon NN cord-016364-80l5mua2 95 6 at at IN cord-016364-80l5mua2 95 7 position position NN cord-016364-80l5mua2 95 8 100 100 CD cord-016364-80l5mua2 95 9 of of IN cord-016364-80l5mua2 95 10 TYRP1 TYRP1 NNP cord-016364-80l5mua2 95 11 was be VBD cord-016364-80l5mua2 95 12 associated associate VBN cord-016364-80l5mua2 95 13 with with IN cord-016364-80l5mua2 95 14 a a DT cord-016364-80l5mua2 95 15 second second JJ cord-016364-80l5mua2 95 16 allele allele NN cord-016364-80l5mua2 95 17 of of IN cord-016364-80l5mua2 95 18 the the DT cord-016364-80l5mua2 95 19 B B NNP cord-016364-80l5mua2 95 20 locus locus NN cord-016364-80l5mua2 95 21 , , , cord-016364-80l5mua2 95 22 cinnamon cinnamon NN cord-016364-80l5mua2 95 23 ( ( -LRB- cord-016364-80l5mua2 95 24 bl bl NNP cord-016364-80l5mua2 95 25 ) ) -RRB- cord-016364-80l5mua2 95 26 . . . cord-016364-80l5mua2 96 1 32 32 CD cord-016364-80l5mua2 96 2 SNP SNP NNP cord-016364-80l5mua2 96 3 discovery discovery NN cord-016364-80l5mua2 96 4 is be VBZ cord-016364-80l5mua2 96 5 planned plan VBN cord-016364-80l5mua2 96 6 in in IN cord-016364-80l5mua2 96 7 the the DT cord-016364-80l5mua2 96 8 7X 7x CD cord-016364-80l5mua2 96 9 whole whole JJ cord-016364-80l5mua2 96 10 genome genome NN cord-016364-80l5mua2 96 11 sequencing sequencing NN cord-016364-80l5mua2 96 12 of of IN cord-016364-80l5mua2 96 13 the the DT cord-016364-80l5mua2 96 14 cat cat NN cord-016364-80l5mua2 96 15 through through IN cord-016364-80l5mua2 96 16 a a DT cord-016364-80l5mua2 96 17 resequencing resequencing NN cord-016364-80l5mua2 96 18 strategy strategy NN cord-016364-80l5mua2 96 19 of of IN cord-016364-80l5mua2 96 20 selected select VBN cord-016364-80l5mua2 96 21 genomic genomic JJ cord-016364-80l5mua2 96 22 regions region NNS cord-016364-80l5mua2 96 23 in in IN cord-016364-80l5mua2 96 24 several several JJ cord-016364-80l5mua2 96 25 cat cat NN cord-016364-80l5mua2 96 26 breeds breed NNS cord-016364-80l5mua2 96 27 as as IN cord-016364-80l5mua2 96 28 was be VBD cord-016364-80l5mua2 96 29 recently recently RB cord-016364-80l5mua2 96 30 performed perform VBN cord-016364-80l5mua2 96 31 in in IN cord-016364-80l5mua2 96 32 the the DT cord-016364-80l5mua2 96 33 7X 7x CD cord-016364-80l5mua2 96 34 whole whole JJ cord-016364-80l5mua2 96 35 genome genome NN cord-016364-80l5mua2 96 36 sequencing sequencing NN cord-016364-80l5mua2 96 37 of of IN cord-016364-80l5mua2 96 38 the the DT cord-016364-80l5mua2 96 39 dog dog NN cord-016364-80l5mua2 96 40 . . . cord-016364-80l5mua2 97 1 19 19 CD cord-016364-80l5mua2 97 2 _SP cord-016364-80l5mua2 98 1 The the DT cord-016364-80l5mua2 98 2 majority majority NN cord-016364-80l5mua2 98 3 of of IN cord-016364-80l5mua2 98 4 hereditary hereditary JJ cord-016364-80l5mua2 98 5 pathologies pathology NNS cord-016364-80l5mua2 98 6 in in IN cord-016364-80l5mua2 98 7 the the DT cord-016364-80l5mua2 98 8 domestic domestic JJ cord-016364-80l5mua2 98 9 cat cat NN cord-016364-80l5mua2 98 10 for for IN cord-016364-80l5mua2 98 11 which which WDT cord-016364-80l5mua2 98 12 the the DT cord-016364-80l5mua2 98 13 gene gene NN cord-016364-80l5mua2 98 14 defect defect NN cord-016364-80l5mua2 98 15 has have VBZ cord-016364-80l5mua2 98 16 been be VBN cord-016364-80l5mua2 98 17 elucidated elucidate VBN cord-016364-80l5mua2 98 18 have have VBP cord-016364-80l5mua2 98 19 resulted result VBN cord-016364-80l5mua2 98 20 from from IN cord-016364-80l5mua2 98 21 the the DT cord-016364-80l5mua2 98 22 analysis analysis NN cord-016364-80l5mua2 98 23 of of IN cord-016364-80l5mua2 98 24 candidate candidate NN cord-016364-80l5mua2 98 25 genes gene NNS cord-016364-80l5mua2 98 26 ( ( -LRB- cord-016364-80l5mua2 98 27 Table Table NNP cord-016364-80l5mua2 98 28 25 25 CD cord-016364-80l5mua2 98 29 - - SYM cord-016364-80l5mua2 98 30 1 1 CD cord-016364-80l5mua2 98 31 ) ) -RRB- cord-016364-80l5mua2 98 32 . . . cord-016364-80l5mua2 99 1 However however RB cord-016364-80l5mua2 99 2 , , , cord-016364-80l5mua2 99 3 with with IN cord-016364-80l5mua2 99 4 the the DT cord-016364-80l5mua2 99 5 availability availability NN cord-016364-80l5mua2 99 6 of of IN cord-016364-80l5mua2 99 7 a a DT cord-016364-80l5mua2 99 8 detailed detailed JJ cord-016364-80l5mua2 99 9 comparative comparative JJ cord-016364-80l5mua2 99 10 map map NN cord-016364-80l5mua2 99 11 , , , cord-016364-80l5mua2 99 12 and and CC cord-016364-80l5mua2 99 13 integration integration NN cord-016364-80l5mua2 99 14 with with IN cord-016364-80l5mua2 99 15 developing develop VBG cord-016364-80l5mua2 99 16 GL GL NNP cord-016364-80l5mua2 99 17 and and CC cord-016364-80l5mua2 99 18 RH RH NNP cord-016364-80l5mua2 99 19 maps map NNS cord-016364-80l5mua2 99 20 , , , cord-016364-80l5mua2 99 21 and and CC cord-016364-80l5mua2 99 22 the the DT cord-016364-80l5mua2 99 23 cat cat NN cord-016364-80l5mua2 99 24 2X 2x CD cord-016364-80l5mua2 99 25 whole whole JJ cord-016364-80l5mua2 99 26 genome genome NN cord-016364-80l5mua2 99 27 sequence sequence NN cord-016364-80l5mua2 99 28 , , , cord-016364-80l5mua2 99 29 linkage linkage NN cord-016364-80l5mua2 99 30 and and CC cord-016364-80l5mua2 99 31 association association NN cord-016364-80l5mua2 99 32 - - HYPH cord-016364-80l5mua2 99 33 based base VBN cord-016364-80l5mua2 99 34 mapping mapping NN cord-016364-80l5mua2 99 35 techniques technique NNS cord-016364-80l5mua2 99 36 have have VBP cord-016364-80l5mua2 99 37 recently recently RB cord-016364-80l5mua2 99 38 identified identify VBN cord-016364-80l5mua2 99 39 causative causative JJ cord-016364-80l5mua2 99 40 mutations mutation NNS cord-016364-80l5mua2 99 41 for for IN cord-016364-80l5mua2 99 42 hereditary hereditary JJ cord-016364-80l5mua2 99 43 disease disease NN cord-016364-80l5mua2 99 44 genes gene NNS cord-016364-80l5mua2 99 45 , , , cord-016364-80l5mua2 99 46 33 33 CD cord-016364-80l5mua2 99 47 , , , cord-016364-80l5mua2 99 48 34 34 CD cord-016364-80l5mua2 99 49 as as RB cord-016364-80l5mua2 99 50 well well RB cord-016364-80l5mua2 99 51 as as IN cord-016364-80l5mua2 99 52 several several JJ cord-016364-80l5mua2 99 53 feline feline JJ cord-016364-80l5mua2 99 54 phenotypes phenotype NNS cord-016364-80l5mua2 99 55 ( ( -LRB- cord-016364-80l5mua2 99 56 Table Table NNP cord-016364-80l5mua2 99 57 25 25 CD cord-016364-80l5mua2 99 58 - - SYM cord-016364-80l5mua2 99 59 1 1 CD cord-016364-80l5mua2 99 60 ) ) -RRB- cord-016364-80l5mua2 99 61 . . . cord-016364-80l5mua2 100 1 18 18 CD cord-016364-80l5mua2 100 2 , , , cord-016364-80l5mua2 100 3 32 32 CD cord-016364-80l5mua2 100 4 , , , cord-016364-80l5mua2 100 5 Once once RB cord-016364-80l5mua2 100 6 a a DT cord-016364-80l5mua2 100 7 genomic genomic JJ cord-016364-80l5mua2 100 8 region region NN cord-016364-80l5mua2 100 9 is be VBZ cord-016364-80l5mua2 100 10 implicated implicate VBN cord-016364-80l5mua2 100 11 from from IN cord-016364-80l5mua2 100 12 association association NN cord-016364-80l5mua2 100 13 - - HYPH cord-016364-80l5mua2 100 14 based base VBN cord-016364-80l5mua2 100 15 or or CC cord-016364-80l5mua2 100 16 linkage linkage NN cord-016364-80l5mua2 100 17 mapping mapping NN cord-016364-80l5mua2 100 18 exercises exercise NNS cord-016364-80l5mua2 100 19 , , , cord-016364-80l5mua2 100 20 fine fine JJ cord-016364-80l5mua2 100 21 mapping mapping NN cord-016364-80l5mua2 100 22 has have VBZ cord-016364-80l5mua2 100 23 been be VBN cord-016364-80l5mua2 100 24 accomplished accomplish VBN cord-016364-80l5mua2 100 25 by by IN cord-016364-80l5mua2 100 26 development development NN cord-016364-80l5mua2 100 27 of of IN cord-016364-80l5mua2 100 28 new new JJ cord-016364-80l5mua2 100 29 STRs STRs NNPS cord-016364-80l5mua2 100 30 or or CC cord-016364-80l5mua2 100 31 SNPs SNPs NNPS cord-016364-80l5mua2 100 32 in in IN cord-016364-80l5mua2 100 33 the the DT cord-016364-80l5mua2 100 34 targeted target VBN cord-016364-80l5mua2 100 35 region region NN cord-016364-80l5mua2 100 36 using use VBG cord-016364-80l5mua2 100 37 the the DT cord-016364-80l5mua2 100 38 cat cat NN cord-016364-80l5mua2 100 39 2X 2x CD cord-016364-80l5mua2 100 40 whole whole JJ cord-016364-80l5mua2 100 41 genome genome NN cord-016364-80l5mua2 100 42 sequence sequence NN cord-016364-80l5mua2 100 43 data datum NNS cord-016364-80l5mua2 100 44 accessed access VBD cord-016364-80l5mua2 100 45 sequence sequence NN cord-016364-80l5mua2 100 46 tagged tag VBN cord-016364-80l5mua2 100 47 sites site NNS cord-016364-80l5mua2 100 48 ( ( -LRB- cord-016364-80l5mua2 100 49 STS STS NNP cord-016364-80l5mua2 100 50 ) ) -RRB- cord-016364-80l5mua2 100 51 , , , cord-016364-80l5mua2 100 52 utilizing utilize VBG cord-016364-80l5mua2 100 53 sequence sequence NN cord-016364-80l5mua2 100 54 information information NN cord-016364-80l5mua2 100 55 from from IN cord-016364-80l5mua2 100 56 the the DT cord-016364-80l5mua2 100 57 cat cat NN cord-016364-80l5mua2 100 58 2X 2x CD cord-016364-80l5mua2 100 59 whole whole JJ cord-016364-80l5mua2 100 60 genome genome NN cord-016364-80l5mua2 100 61 sequencing sequencing NN cord-016364-80l5mua2 100 62 effort effort NN cord-016364-80l5mua2 100 63 , , , cord-016364-80l5mua2 100 64 which which WDT cord-016364-80l5mua2 100 65 ultimately ultimately RB cord-016364-80l5mua2 100 66 identifi identifi VBD cord-016364-80l5mua2 100 67 ed ed NNP cord-016364-80l5mua2 100 68 an an DT cord-016364-80l5mua2 100 69 ∼140 ∼140 NNP cord-016364-80l5mua2 100 70 kb kb NNP cord-016364-80l5mua2 100 71 deletion deletion NN cord-016364-80l5mua2 100 72 and and CC cord-016364-80l5mua2 100 73 a a DT cord-016364-80l5mua2 100 74 novel novel JJ cord-016364-80l5mua2 100 75 gene gene NN cord-016364-80l5mua2 100 76 candidate candidate NN cord-016364-80l5mua2 100 77 , , , cord-016364-80l5mua2 100 78 LIX1 lix1 RB cord-016364-80l5mua2 100 79 34 34 CD cord-016364-80l5mua2 101 1 ( ( -LRB- cord-016364-80l5mua2 101 2 Figure figure NN cord-016364-80l5mua2 101 3 25 25 CD cord-016364-80l5mua2 101 4 - - SYM cord-016364-80l5mua2 101 5 4 4 CD cord-016364-80l5mua2 101 6 ) ) -RRB- cord-016364-80l5mua2 101 7 . . . cord-016364-80l5mua2 102 1 Though though IN cord-016364-80l5mua2 102 2 the the DT cord-016364-80l5mua2 102 3 function function NN cord-016364-80l5mua2 102 4 of of IN cord-016364-80l5mua2 102 5 LIX1 LIX1 NNP cord-016364-80l5mua2 102 6 is be VBZ cord-016364-80l5mua2 102 7 unknown unknown JJ cord-016364-80l5mua2 102 8 , , , cord-016364-80l5mua2 102 9 the the DT cord-016364-80l5mua2 102 10 predicted predict VBN cord-016364-80l5mua2 102 11 secondary secondary JJ cord-016364-80l5mua2 102 12 structure structure NN cord-016364-80l5mua2 102 13 is be VBZ cord-016364-80l5mua2 102 14 compatible compatible JJ cord-016364-80l5mua2 102 15 with with IN cord-016364-80l5mua2 102 16 a a DT cord-016364-80l5mua2 102 17 role role NN cord-016364-80l5mua2 102 18 in in IN cord-016364-80l5mua2 102 19 RNA RNA NNP cord-016364-80l5mua2 102 20 metabolism metabolism NN cord-016364-80l5mua2 102 21 . . . cord-016364-80l5mua2 103 1 An an DT cord-016364-80l5mua2 103 2 exon exon NN cord-016364-80l5mua2 103 3 sequence sequence NN cord-016364-80l5mua2 103 4 screen screen NN cord-016364-80l5mua2 103 5 of of IN cord-016364-80l5mua2 103 6 25 25 CD cord-016364-80l5mua2 103 7 human human JJ cord-016364-80l5mua2 103 8 SMA sma JJ cord-016364-80l5mua2 103 9 cases case NNS cord-016364-80l5mua2 103 10 , , , cord-016364-80l5mua2 103 11 not not RB cord-016364-80l5mua2 103 12 otherwise otherwise RB cord-016364-80l5mua2 103 13 explicable explicable JJ cord-016364-80l5mua2 103 14 by by IN cord-016364-80l5mua2 103 15 mutations mutation NNS cord-016364-80l5mua2 103 16 at at IN cord-016364-80l5mua2 103 17 the the DT cord-016364-80l5mua2 103 18 SMN1 SMN1 NNP cord-016364-80l5mua2 103 19 locus locus NN cord-016364-80l5mua2 103 20 , , , cord-016364-80l5mua2 103 21 failed fail VBD cord-016364-80l5mua2 103 22 to to TO cord-016364-80l5mua2 103 23 identify identify VB cord-016364-80l5mua2 103 24 comparable comparable JJ cord-016364-80l5mua2 103 25 LIX1 LIX1 NNP cord-016364-80l5mua2 103 26 mutations mutation NNS cord-016364-80l5mua2 103 27 . . . cord-016364-80l5mua2 104 1 34 34 CD cord-016364-80l5mua2 105 1 The the DT cord-016364-80l5mua2 105 2 SMN1 SMN1 NNP cord-016364-80l5mua2 105 3 gene gene NN cord-016364-80l5mua2 105 4 product product NN cord-016364-80l5mua2 105 5 , , , cord-016364-80l5mua2 105 6 SMN SMN NNP cord-016364-80l5mua2 105 7 , , , cord-016364-80l5mua2 105 8 is be VBZ cord-016364-80l5mua2 105 9 a a DT cord-016364-80l5mua2 105 10 ubiquitously ubiquitously RB cord-016364-80l5mua2 105 11 expressed express VBN cord-016364-80l5mua2 105 12 protein protein NN cord-016364-80l5mua2 105 13 member member NN cord-016364-80l5mua2 105 14 of of IN cord-016364-80l5mua2 105 15 multiple multiple JJ cord-016364-80l5mua2 105 16 ribonucleoprotein ribonucleoprotein NN cord-016364-80l5mua2 105 17 complexes complex NNS cord-016364-80l5mua2 105 18 with with IN cord-016364-80l5mua2 105 19 diverse diverse JJ cord-016364-80l5mua2 105 20 roles role NNS cord-016364-80l5mua2 105 21 in in IN cord-016364-80l5mua2 105 22 RNA RNA NNP cord-016364-80l5mua2 105 23 metabolism metabolism NN cord-016364-80l5mua2 105 24 , , , cord-016364-80l5mua2 105 25 splicing splicing NN cord-016364-80l5mua2 105 26 , , , cord-016364-80l5mua2 105 27 and and CC cord-016364-80l5mua2 105 28 transport transport VB cord-016364-80l5mua2 105 29 in in IN cord-016364-80l5mua2 105 30 all all DT cord-016364-80l5mua2 105 31 cells cell NNS cord-016364-80l5mua2 105 32 . . . cord-016364-80l5mua2 106 1 62 62 CD cord-016364-80l5mua2 106 2 , , , cord-016364-80l5mua2 106 3 63 63 CD cord-016364-80l5mua2 107 1 A a DT cord-016364-80l5mua2 107 2 central central JJ cord-016364-80l5mua2 107 3 focus focus NN cord-016364-80l5mua2 107 4 of of IN cord-016364-80l5mua2 107 5 SMA SMA NNP cord-016364-80l5mua2 107 6 research research NN cord-016364-80l5mua2 107 7 remains remain VBZ cord-016364-80l5mua2 107 8 to to TO cord-016364-80l5mua2 107 9 discern discern VB cord-016364-80l5mua2 107 10 the the DT cord-016364-80l5mua2 107 11 disease disease NN cord-016364-80l5mua2 107 12 mechanism(s mechanism(s NNP cord-016364-80l5mua2 107 13 ) ) -RRB- cord-016364-80l5mua2 107 14 and and CC cord-016364-80l5mua2 107 15 to to TO cord-016364-80l5mua2 107 16 understand understand VB cord-016364-80l5mua2 107 17 why why WRB cord-016364-80l5mua2 107 18 the the DT cord-016364-80l5mua2 107 19 primary primary JJ cord-016364-80l5mua2 107 20 disease disease NN cord-016364-80l5mua2 107 21 pathology pathology NN cord-016364-80l5mua2 107 22 is be VBZ cord-016364-80l5mua2 107 23 localized localize VBN cord-016364-80l5mua2 107 24 to to IN cord-016364-80l5mua2 107 25 spinal spinal JJ cord-016364-80l5mua2 107 26 lower low JJR cord-016364-80l5mua2 107 27 motor motor NN cord-016364-80l5mua2 107 28 neurons neuron NNS cord-016364-80l5mua2 107 29 when when WRB cord-016364-80l5mua2 107 30 all all DT cord-016364-80l5mua2 107 31 cells cell NNS cord-016364-80l5mua2 107 32 require require VBP cord-016364-80l5mua2 107 33 SMN SMN NNP cord-016364-80l5mua2 107 34 function function NN cord-016364-80l5mua2 107 35 . . . cord-016364-80l5mua2 108 1 LIX1 lix1 JJ cord-016364-80l5mua2 108 2 expression expression NN cord-016364-80l5mua2 108 3 is be VBZ cord-016364-80l5mua2 108 4 largely largely RB cord-016364-80l5mua2 108 5 restricted restricted JJ cord-016364-80l5mua2 108 6 to to IN cord-016364-80l5mua2 108 7 the the DT cord-016364-80l5mua2 108 8 central central JJ cord-016364-80l5mua2 108 9 nervous nervous JJ cord-016364-80l5mua2 108 10 system system NN cord-016364-80l5mua2 108 11 ( ( -LRB- cord-016364-80l5mua2 108 12 CNS CNS NNP cord-016364-80l5mua2 108 13 ) ) -RRB- cord-016364-80l5mua2 108 14 , , , cord-016364-80l5mua2 108 15 primarily primarily RB cord-016364-80l5mua2 108 16 in in IN cord-016364-80l5mua2 108 17 spinal spinal JJ cord-016364-80l5mua2 108 18 motor motor NN cord-016364-80l5mua2 108 19 neurons neuron NNS cord-016364-80l5mua2 108 20 , , , cord-016364-80l5mua2 108 21 thus thus RB cord-016364-80l5mua2 108 22 offering offer VBG cord-016364-80l5mua2 108 23 an an DT cord-016364-80l5mua2 108 24 explanation explanation NN cord-016364-80l5mua2 108 25 of of IN cord-016364-80l5mua2 108 26 the the DT cord-016364-80l5mua2 108 27 tissue tissue NN cord-016364-80l5mua2 108 28 restriction restriction NN cord-016364-80l5mua2 108 29 of of IN cord-016364-80l5mua2 108 30 pathology pathology NN cord-016364-80l5mua2 108 31 in in IN cord-016364-80l5mua2 108 32 feline feline JJ cord-016364-80l5mua2 108 33 SMA SMA NNP cord-016364-80l5mua2 108 34 . . . cord-016364-80l5mua2 109 1 Determination determination NN cord-016364-80l5mua2 109 2 of of IN cord-016364-80l5mua2 109 3 LIX1 LIX1 NNP cord-016364-80l5mua2 109 4 function function NN cord-016364-80l5mua2 109 5 may may MD cord-016364-80l5mua2 109 6 well well RB cord-016364-80l5mua2 109 7 provide provide VB cord-016364-80l5mua2 109 8 fresh fresh JJ cord-016364-80l5mua2 109 9 insight insight NN cord-016364-80l5mua2 109 10 into into IN cord-016364-80l5mua2 109 11 the the DT cord-016364-80l5mua2 109 12 mechanisms mechanism NNS cord-016364-80l5mua2 109 13 of of IN cord-016364-80l5mua2 109 14 human human JJ cord-016364-80l5mua2 109 15 SMA SMA NNP cord-016364-80l5mua2 109 16 pathology pathology NN cord-016364-80l5mua2 109 17 , , , cord-016364-80l5mua2 109 18 impetus impetus NN cord-016364-80l5mua2 109 19 for for IN cord-016364-80l5mua2 109 20 more more RBR cord-016364-80l5mua2 109 21 targeted target VBN cord-016364-80l5mua2 109 22 therapeutics therapeutic NNS cord-016364-80l5mua2 109 23 , , , cord-016364-80l5mua2 109 24 and and CC cord-016364-80l5mua2 109 25 answers answer NNS cord-016364-80l5mua2 109 26 to to IN cord-016364-80l5mua2 109 27 fundamental fundamental JJ cord-016364-80l5mua2 109 28 questions question NNS cord-016364-80l5mua2 109 29 of of IN cord-016364-80l5mua2 109 30 motor motor NN cord-016364-80l5mua2 109 31 neuron neuron NN cord-016364-80l5mua2 109 32 development development NN cord-016364-80l5mua2 109 33 , , , cord-016364-80l5mua2 109 34 maintenance maintenance NN cord-016364-80l5mua2 109 35 , , , cord-016364-80l5mua2 109 36 and/or and/or CC cord-016364-80l5mua2 109 37 function function NN cord-016364-80l5mua2 109 38 . . . cord-016364-80l5mua2 110 1 through through IN cord-016364-80l5mua2 110 2 the the DT cord-016364-80l5mua2 110 3 cat cat NN cord-016364-80l5mua2 110 4 genome genome NN cord-016364-80l5mua2 110 5 browser browser NN cord-016364-80l5mua2 110 6 , , , cord-016364-80l5mua2 110 7 GARFIELD GARFIELD NNP cord-016364-80l5mua2 110 8 . . . cord-016364-80l5mua2 111 1 17 17 CD cord-016364-80l5mua2 112 1 A a DT cord-016364-80l5mua2 112 2 recent recent JJ cord-016364-80l5mua2 112 3 report report NN cord-016364-80l5mua2 112 4 of of IN cord-016364-80l5mua2 112 5 the the DT cord-016364-80l5mua2 112 6 mapping mapping NN cord-016364-80l5mua2 112 7 and and CC cord-016364-80l5mua2 112 8 characterization characterization NN cord-016364-80l5mua2 112 9 of of IN cord-016364-80l5mua2 112 10 a a DT cord-016364-80l5mua2 112 11 novel novel NN cord-016364-80l5mua2 112 12 gene gene NN cord-016364-80l5mua2 112 13 causative causative NN cord-016364-80l5mua2 112 14 of of IN cord-016364-80l5mua2 112 15 feline feline JJ cord-016364-80l5mua2 112 16 spinal spinal JJ cord-016364-80l5mua2 112 17 muscular muscular JJ cord-016364-80l5mua2 112 18 atrophy atrophy NN cord-016364-80l5mua2 112 19 34 34 CD cord-016364-80l5mua2 112 20 marked mark VBD cord-016364-80l5mua2 112 21 the the DT cord-016364-80l5mua2 112 22 first first JJ cord-016364-80l5mua2 112 23 identification identification NN cord-016364-80l5mua2 112 24 of of IN cord-016364-80l5mua2 112 25 a a DT cord-016364-80l5mua2 112 26 disease disease NN cord-016364-80l5mua2 112 27 gene gene NN cord-016364-80l5mua2 112 28 purely purely RB cord-016364-80l5mua2 112 29 from from IN cord-016364-80l5mua2 112 30 positional positional JJ cord-016364-80l5mua2 112 31 reasoning reasoning NN cord-016364-80l5mua2 112 32 . . . cord-016364-80l5mua2 113 1 Human human JJ cord-016364-80l5mua2 113 2 spinal spinal JJ cord-016364-80l5mua2 113 3 muscular muscular JJ cord-016364-80l5mua2 113 4 atrophies atrophy NNS cord-016364-80l5mua2 113 5 ( ( -LRB- cord-016364-80l5mua2 113 6 SMAs SMAs NNP cord-016364-80l5mua2 113 7 ) ) -RRB- cord-016364-80l5mua2 113 8 are be VBP cord-016364-80l5mua2 113 9 a a DT cord-016364-80l5mua2 113 10 genetically genetically RB cord-016364-80l5mua2 113 11 heterogeneous heterogeneous JJ cord-016364-80l5mua2 113 12 group group NN cord-016364-80l5mua2 113 13 of of IN cord-016364-80l5mua2 113 14 neuropathies neuropathy NNS cord-016364-80l5mua2 113 15 that that WDT cord-016364-80l5mua2 113 16 varies vary VBZ cord-016364-80l5mua2 113 17 in in IN cord-016364-80l5mua2 113 18 clinical clinical JJ cord-016364-80l5mua2 113 19 severity severity NN cord-016364-80l5mua2 113 20 , , , cord-016364-80l5mua2 113 21 from from IN cord-016364-80l5mua2 113 22 lethal lethal JJ cord-016364-80l5mua2 113 23 in in IN cord-016364-80l5mua2 113 24 infancy infancy NN cord-016364-80l5mua2 113 25 to to IN cord-016364-80l5mua2 113 26 onset onset NN cord-016364-80l5mua2 113 27 of of IN cord-016364-80l5mua2 113 28 mild mild JJ cord-016364-80l5mua2 113 29 weakness weakness NN cord-016364-80l5mua2 113 30 in in IN cord-016364-80l5mua2 113 31 adulthood adulthood NN cord-016364-80l5mua2 113 32 , , , cord-016364-80l5mua2 113 33 but but CC cord-016364-80l5mua2 113 34 all all DT cord-016364-80l5mua2 113 35 are be VBP cord-016364-80l5mua2 113 36 characterized characterize VBN cord-016364-80l5mua2 113 37 by by IN cord-016364-80l5mua2 113 38 neurogenic neurogenic JJ cord-016364-80l5mua2 113 39 muscle muscle NN cord-016364-80l5mua2 113 40 atrophy atrophy NN cord-016364-80l5mua2 113 41 due due IN cord-016364-80l5mua2 113 42 to to IN cord-016364-80l5mua2 113 43 degeneration degeneration NN cord-016364-80l5mua2 113 44 of of IN cord-016364-80l5mua2 113 45 lower low JJR cord-016364-80l5mua2 113 46 motor motor NN cord-016364-80l5mua2 113 47 neurons neuron NNS cord-016364-80l5mua2 113 48 of of IN cord-016364-80l5mua2 113 49 the the DT cord-016364-80l5mua2 113 50 spinal spinal JJ cord-016364-80l5mua2 113 51 cord cord NN cord-016364-80l5mua2 113 52 . . . cord-016364-80l5mua2 114 1 58 58 CD cord-016364-80l5mua2 115 1 For for IN cord-016364-80l5mua2 115 2 approximately approximately RB cord-016364-80l5mua2 115 3 97 97 CD cord-016364-80l5mua2 115 4 % % NN cord-016364-80l5mua2 115 5 of of IN cord-016364-80l5mua2 115 6 people people NNS cord-016364-80l5mua2 115 7 affected affect VBN cord-016364-80l5mua2 115 8 with with IN cord-016364-80l5mua2 115 9 SMA SMA NNP cord-016364-80l5mua2 115 10 , , , cord-016364-80l5mua2 115 11 disease disease NN cord-016364-80l5mua2 115 12 pathology pathology NN cord-016364-80l5mua2 115 13 is be VBZ cord-016364-80l5mua2 115 14 attributable attributable JJ cord-016364-80l5mua2 115 15 to to IN cord-016364-80l5mua2 115 16 a a DT cord-016364-80l5mua2 115 17 mutation mutation NN cord-016364-80l5mua2 115 18 in in IN cord-016364-80l5mua2 115 19 the the DT cord-016364-80l5mua2 115 20 SMN1 SMN1 NNP cord-016364-80l5mua2 115 21 gene gene NN cord-016364-80l5mua2 115 22 , , , cord-016364-80l5mua2 115 23 on on IN cord-016364-80l5mua2 115 24 human human JJ cord-016364-80l5mua2 115 25 chromosome chromosome NN cord-016364-80l5mua2 115 26 5q13 5q13 NNP cord-016364-80l5mua2 115 27 , , , cord-016364-80l5mua2 115 28 which which WDT cord-016364-80l5mua2 115 29 is be VBZ cord-016364-80l5mua2 115 30 subject subject JJ cord-016364-80l5mua2 115 31 to to IN cord-016364-80l5mua2 115 32 a a DT cord-016364-80l5mua2 115 33 high high JJ cord-016364-80l5mua2 115 34 frequency frequency NN cord-016364-80l5mua2 115 35 of of IN cord-016364-80l5mua2 115 36 deletions deletion NNS cord-016364-80l5mua2 115 37 and and CC cord-016364-80l5mua2 115 38 gene gene NN cord-016364-80l5mua2 115 39 conversion conversion NN cord-016364-80l5mua2 115 40 events event NNS cord-016364-80l5mua2 115 41 with with IN cord-016364-80l5mua2 115 42 the the DT cord-016364-80l5mua2 115 43 divergent divergent JJ cord-016364-80l5mua2 115 44 and and CC cord-016364-80l5mua2 115 45 only only RB cord-016364-80l5mua2 115 46 partially partially RB cord-016364-80l5mua2 115 47 functional functional JJ cord-016364-80l5mua2 115 48 centromeric centromeric NNP cord-016364-80l5mua2 115 49 copy copy NN cord-016364-80l5mua2 115 50 / / SYM cord-016364-80l5mua2 115 51 copies copy NNS cord-016364-80l5mua2 115 52 of of IN cord-016364-80l5mua2 115 53 the the DT cord-016364-80l5mua2 115 54 duplicated duplicate VBN cord-016364-80l5mua2 115 55 SMN2 SMN2 NNP cord-016364-80l5mua2 115 56 locus locus NN cord-016364-80l5mua2 115 57 . . . cord-016364-80l5mua2 116 1 59 59 CD cord-016364-80l5mua2 116 2 , , , cord-016364-80l5mua2 116 3 60 60 CD cord-016364-80l5mua2 117 1 A a DT cord-016364-80l5mua2 117 2 domestic domestic JJ cord-016364-80l5mua2 117 3 cat cat NN cord-016364-80l5mua2 117 4 model model NN cord-016364-80l5mua2 117 5 of of IN cord-016364-80l5mua2 117 6 SMA SMA NNP cord-016364-80l5mua2 117 7 has have VBZ cord-016364-80l5mua2 117 8 been be VBN cord-016364-80l5mua2 117 9 described describe VBN cord-016364-80l5mua2 117 10 that that DT cord-016364-80l5mua2 117 11 is be VBZ cord-016364-80l5mua2 117 12 a a DT cord-016364-80l5mua2 117 13 model model NN cord-016364-80l5mua2 117 14 of of IN cord-016364-80l5mua2 117 15 autosomal autosomal JJ cord-016364-80l5mua2 117 16 recessive recessive JJ cord-016364-80l5mua2 117 17 juvenile juvenile JJ cord-016364-80l5mua2 117 18 - - HYPH cord-016364-80l5mua2 117 19 onset onset NN cord-016364-80l5mua2 117 20 SMA SMA NNP cord-016364-80l5mua2 117 21 . . . cord-016364-80l5mua2 118 1 61 61 CD cord-016364-80l5mua2 119 1 With with IN cord-016364-80l5mua2 119 2 the the DT cord-016364-80l5mua2 119 3 feline feline JJ cord-016364-80l5mua2 119 4 SMN SMN NNP cord-016364-80l5mua2 119 5 gene gene NN cord-016364-80l5mua2 119 6 excluded exclude VBN cord-016364-80l5mua2 119 7 as as IN cord-016364-80l5mua2 119 8 the the DT cord-016364-80l5mua2 119 9 disease disease NN cord-016364-80l5mua2 119 10 locus locus NN cord-016364-80l5mua2 119 11 , , , cord-016364-80l5mua2 119 12 61 61 CD cord-016364-80l5mua2 119 13 a a DT cord-016364-80l5mua2 119 14 full full JJ cord-016364-80l5mua2 119 15 genome genome NN cord-016364-80l5mua2 119 16 linkage linkage NN cord-016364-80l5mua2 119 17 scan scan NN cord-016364-80l5mua2 119 18 was be VBD cord-016364-80l5mua2 119 19 conducted conduct VBN cord-016364-80l5mua2 119 20 in in IN cord-016364-80l5mua2 119 21 a a DT cord-016364-80l5mua2 119 22 pedigree pedigree NN cord-016364-80l5mua2 119 23 segregating segregate VBG cord-016364-80l5mua2 119 24 for for IN cord-016364-80l5mua2 119 25 SMA SMA NNP cord-016364-80l5mua2 119 26 . . . cord-016364-80l5mua2 120 1 61 61 CD cord-016364-80l5mua2 121 1 The the DT cord-016364-80l5mua2 121 2 disease disease NN cord-016364-80l5mua2 121 3 phenotype phenotype NN cord-016364-80l5mua2 121 4 was be VBD cord-016364-80l5mua2 121 5 linked link VBN cord-016364-80l5mua2 121 6 to to IN cord-016364-80l5mua2 121 7 chromosome chromosome NN cord-016364-80l5mua2 121 8 A1q A1q NNP cord-016364-80l5mua2 121 9 , , , cord-016364-80l5mua2 121 10 34 34 CD cord-016364-80l5mua2 121 11 in in IN cord-016364-80l5mua2 121 12 a a DT cord-016364-80l5mua2 121 13 region region NN cord-016364-80l5mua2 121 14 of of IN cord-016364-80l5mua2 121 15 conserved conserve VBN cord-016364-80l5mua2 121 16 synteny synteny NN cord-016364-80l5mua2 121 17 to to IN cord-016364-80l5mua2 121 18 human human JJ cord-016364-80l5mua2 121 19 chromosome chromosome NN cord-016364-80l5mua2 121 20 5q15 5q15 CD cord-016364-80l5mua2 121 21 . . . cord-016364-80l5mua2 122 1 Fine fine JJ cord-016364-80l5mua2 122 2 mapping mapping NN cord-016364-80l5mua2 122 3 was be VBD cord-016364-80l5mua2 122 4 accomplished accomplish VBN cord-016364-80l5mua2 122 5 with with IN cord-016364-80l5mua2 122 6 development development NN cord-016364-80l5mua2 122 7 of of IN cord-016364-80l5mua2 122 8 new new JJ cord-016364-80l5mua2 122 9 STRs str NNS cord-016364-80l5mua2 122 10 and and CC cord-016364-80l5mua2 122 11 The the DT cord-016364-80l5mua2 122 12 world world NN cord-016364-80l5mua2 122 13 's 's POS cord-016364-80l5mua2 122 14 veterinary veterinary JJ cord-016364-80l5mua2 122 15 schools school NNS cord-016364-80l5mua2 122 16 produce produce VBP cord-016364-80l5mua2 122 17 thousands thousand NNS cord-016364-80l5mua2 122 18 of of IN cord-016364-80l5mua2 122 19 practitioners practitioner NNS cord-016364-80l5mua2 122 20 each each DT cord-016364-80l5mua2 122 21 year year NN cord-016364-80l5mua2 122 22 , , , cord-016364-80l5mua2 122 23 most most JJS cord-016364-80l5mua2 122 24 of of IN cord-016364-80l5mua2 122 25 whom whom WP cord-016364-80l5mua2 122 26 carefully carefully RB cord-016364-80l5mua2 122 27 document document VBP cord-016364-80l5mua2 122 28 genetic genetic JJ cord-016364-80l5mua2 122 29 and and CC cord-016364-80l5mua2 122 30 chronic chronic JJ cord-016364-80l5mua2 122 31 diseases disease NNS cord-016364-80l5mua2 122 32 of of IN cord-016364-80l5mua2 122 33 our -PRON- PRP$ cord-016364-80l5mua2 122 34 pets pet NNS cord-016364-80l5mua2 122 35 . . . cord-016364-80l5mua2 123 1 The the DT cord-016364-80l5mua2 123 2 result result NN cord-016364-80l5mua2 123 3 is be VBZ cord-016364-80l5mua2 123 4 a a DT cord-016364-80l5mua2 123 5 comprehensive comprehensive JJ cord-016364-80l5mua2 123 6 veterinary veterinary JJ cord-016364-80l5mua2 123 7 literature literature NN cord-016364-80l5mua2 123 8 that that WDT cord-016364-80l5mua2 123 9 has have VBZ cord-016364-80l5mua2 123 10 described describe VBN cord-016364-80l5mua2 123 11 over over IN cord-016364-80l5mua2 123 12 200 200 CD cord-016364-80l5mua2 123 13 feline feline JJ cord-016364-80l5mua2 123 14 hereditary hereditary JJ cord-016364-80l5mua2 123 15 pathologies pathology NNS cord-016364-80l5mua2 123 16 17 17 CD cord-016364-80l5mua2 123 17 ( ( -LRB- cord-016364-80l5mua2 123 18 http://www.angis.org.au/ http://www.angis.org.au/ NNP cord-016364-80l5mua2 123 19 ) ) -RRB- cord-016364-80l5mua2 123 20 . . . cord-016364-80l5mua2 124 1 The the DT cord-016364-80l5mua2 124 2 clinical clinical JJ cord-016364-80l5mua2 124 3 and and CC cord-016364-80l5mua2 124 4 physiological physiological JJ cord-016364-80l5mua2 124 5 study study NN cord-016364-80l5mua2 124 6 of of IN cord-016364-80l5mua2 124 7 these these DT cord-016364-80l5mua2 124 8 feline feline JJ cord-016364-80l5mua2 124 9 hereditary hereditary JJ cord-016364-80l5mua2 124 10 diseases disease NNS cord-016364-80l5mua2 124 11 provides provide VBZ cord-016364-80l5mua2 124 12 a a DT cord-016364-80l5mua2 124 13 strong strong JJ cord-016364-80l5mua2 124 14 comparative comparative JJ cord-016364-80l5mua2 124 15 medicine medicine NN cord-016364-80l5mua2 124 16 opportunity opportunity NN cord-016364-80l5mua2 124 17 for for IN cord-016364-80l5mua2 124 18 prevention prevention NN cord-016364-80l5mua2 124 19 , , , cord-016364-80l5mua2 124 20 diagnostics diagnostic NNS cord-016364-80l5mua2 124 21 , , , cord-016364-80l5mua2 124 22 and and CC cord-016364-80l5mua2 124 23 treatment treatment NN cord-016364-80l5mua2 124 24 studies study NNS cord-016364-80l5mua2 124 25 in in IN cord-016364-80l5mua2 124 26 a a DT cord-016364-80l5mua2 124 27 laboratory laboratory NN cord-016364-80l5mua2 124 28 setting setting NN cord-016364-80l5mua2 124 29 . . . cord-016364-80l5mua2 125 1 Additionally additionally RB cord-016364-80l5mua2 125 2 , , , cord-016364-80l5mua2 125 3 large large JJ cord-016364-80l5mua2 125 4 animal animal NN cord-016364-80l5mua2 125 5 homologues homologue NNS cord-016364-80l5mua2 125 6 are be VBP cord-016364-80l5mua2 125 7 similar similar JJ cord-016364-80l5mua2 125 8 to to IN cord-016364-80l5mua2 125 9 humans human NNS cord-016364-80l5mua2 125 10 in in IN cord-016364-80l5mua2 125 11 natural natural JJ cord-016364-80l5mua2 125 12 genetic genetic JJ cord-016364-80l5mua2 125 13 diversity diversity NN cord-016364-80l5mua2 125 14 and and CC cord-016364-80l5mua2 125 15 offer offer VB cord-016364-80l5mua2 125 16 the the DT cord-016364-80l5mua2 125 17 possibility possibility NN cord-016364-80l5mua2 125 18 of of IN cord-016364-80l5mua2 125 19 evaluating evaluate VBG cord-016364-80l5mua2 125 20 long long JJ cord-016364-80l5mua2 125 21 - - HYPH cord-016364-80l5mua2 125 22 term term NN cord-016364-80l5mua2 125 23 effects effect NNS cord-016364-80l5mua2 125 24 of of IN cord-016364-80l5mua2 125 25 treatment treatment NN cord-016364-80l5mua2 125 26 . . . cord-016364-80l5mua2 126 1 64 64 CD cord-016364-80l5mua2 127 1 To to IN cord-016364-80l5mua2 127 2 date date NN cord-016364-80l5mua2 127 3 , , , cord-016364-80l5mua2 127 4 causal causal JJ cord-016364-80l5mua2 127 5 mutations mutation NNS cord-016364-80l5mua2 127 6 have have VBP cord-016364-80l5mua2 127 7 been be VBN cord-016364-80l5mua2 127 8 characterized characterize VBN cord-016364-80l5mua2 127 9 in in IN cord-016364-80l5mua2 127 10 19 19 CD cord-016364-80l5mua2 127 11 felid felid JJ cord-016364-80l5mua2 127 12 genes gene NNS cord-016364-80l5mua2 127 13 that that WDT cord-016364-80l5mua2 127 14 cause cause VBP cord-016364-80l5mua2 127 15 hereditary hereditary JJ cord-016364-80l5mua2 127 16 disease disease NN cord-016364-80l5mua2 127 17 ( ( -LRB- cord-016364-80l5mua2 127 18 Table table NN cord-016364-80l5mua2 127 19 25 25 CD cord-016364-80l5mua2 127 20 -1 -1 CD cord-016364-80l5mua2 127 21 ) ) -RRB- cord-016364-80l5mua2 127 22 . . . cord-016364-80l5mua2 128 1 The the DT cord-016364-80l5mua2 128 2 largest large JJS cord-016364-80l5mua2 128 3 representation representation NN cord-016364-80l5mua2 128 4 comes come VBZ cord-016364-80l5mua2 128 5 from from IN cord-016364-80l5mua2 128 6 lysosomal lysosomal JJ cord-016364-80l5mua2 128 7 storage storage NN cord-016364-80l5mua2 128 8 enzyme enzyme NN cord-016364-80l5mua2 128 9 disorders disorder NNS cord-016364-80l5mua2 128 10 that that WDT cord-016364-80l5mua2 128 11 arise arise VBP cord-016364-80l5mua2 128 12 from from IN cord-016364-80l5mua2 128 13 defects defect NNS cord-016364-80l5mua2 128 14 in in IN cord-016364-80l5mua2 128 15 genes gene NNS cord-016364-80l5mua2 128 16 playing play VBG cord-016364-80l5mua2 128 17 a a DT cord-016364-80l5mua2 128 18 role role NN cord-016364-80l5mua2 128 19 in in IN cord-016364-80l5mua2 128 20 degradation degradation NN cord-016364-80l5mua2 128 21 of of IN cord-016364-80l5mua2 128 22 macromolecules macromolecule NNS cord-016364-80l5mua2 128 23 targeted target VBN cord-016364-80l5mua2 128 24 to to IN cord-016364-80l5mua2 128 25 the the DT cord-016364-80l5mua2 128 26 lysosomes lysosome NNS cord-016364-80l5mua2 128 27 . . . cord-016364-80l5mua2 129 1 Many many JJ cord-016364-80l5mua2 129 2 of of IN cord-016364-80l5mua2 129 3 the the DT cord-016364-80l5mua2 129 4 genes gene NNS cord-016364-80l5mua2 129 5 that that WDT cord-016364-80l5mua2 129 6 cause cause VBP cord-016364-80l5mua2 129 7 these these DT cord-016364-80l5mua2 129 8 pathologies pathology NNS cord-016364-80l5mua2 129 9 have have VBP cord-016364-80l5mua2 129 10 been be VBN cord-016364-80l5mua2 129 11 mapped map VBN cord-016364-80l5mua2 129 12 in in IN cord-016364-80l5mua2 129 13 the the DT cord-016364-80l5mua2 129 14 cat cat NN cord-016364-80l5mua2 129 15 . . . cord-016364-80l5mua2 130 1 65 65 CD cord-016364-80l5mua2 130 2 Corrective corrective JJ cord-016364-80l5mua2 130 3 therapeutic therapeutic JJ cord-016364-80l5mua2 130 4 strategies strategy NNS cord-016364-80l5mua2 130 5 have have VBP cord-016364-80l5mua2 130 6 been be VBN cord-016364-80l5mua2 130 7 proposed propose VBN cord-016364-80l5mua2 130 8 and and CC cord-016364-80l5mua2 130 9 examined examine VBN cord-016364-80l5mua2 130 10 in in IN cord-016364-80l5mua2 130 11 the the DT cord-016364-80l5mua2 130 12 cat cat NN cord-016364-80l5mua2 130 13 , , , cord-016364-80l5mua2 130 14 including include VBG cord-016364-80l5mua2 130 15 enzyme enzyme NN cord-016364-80l5mua2 130 16 replacement replacement NN cord-016364-80l5mua2 130 17 , , , cord-016364-80l5mua2 130 18 heterologous heterologous JJ cord-016364-80l5mua2 130 19 bone bone NN cord-016364-80l5mua2 130 20 marrow marrow NN cord-016364-80l5mua2 130 21 transplantation transplantation NN cord-016364-80l5mua2 130 22 , , , cord-016364-80l5mua2 130 23 and and CC cord-016364-80l5mua2 130 24 substrate substrate NN cord-016364-80l5mua2 130 25 reduction reduction NN cord-016364-80l5mua2 130 26 therapy therapy NN cord-016364-80l5mua2 130 27 . . . cord-016364-80l5mua2 131 1 64 64 CD cord-016364-80l5mua2 131 2 , , , cord-016364-80l5mua2 131 3 66 66 CD cord-016364-80l5mua2 131 4 Limitations limitation NNS cord-016364-80l5mua2 131 5 to to IN cord-016364-80l5mua2 131 6 these these DT cord-016364-80l5mua2 131 7 treatment treatment NN cord-016364-80l5mua2 131 8 strategies strategy NNS cord-016364-80l5mua2 131 9 include include VBP cord-016364-80l5mua2 131 10 high high JJ cord-016364-80l5mua2 131 11 morbidity morbidity NN cord-016364-80l5mua2 131 12 and and CC cord-016364-80l5mua2 131 13 mortality mortality NN cord-016364-80l5mua2 131 14 , , , cord-016364-80l5mua2 131 15 limited limited JJ cord-016364-80l5mua2 131 16 positive positive JJ cord-016364-80l5mua2 131 17 outcomes outcome NNS cord-016364-80l5mua2 131 18 , , , cord-016364-80l5mua2 131 19 incomplete incomplete JJ cord-016364-80l5mua2 131 20 response response NN cord-016364-80l5mua2 131 21 to to IN cord-016364-80l5mua2 131 22 therapy therapy NN cord-016364-80l5mua2 131 23 , , , cord-016364-80l5mua2 131 24 cost cost NN cord-016364-80l5mua2 131 25 , , , cord-016364-80l5mua2 131 26 and and CC cord-016364-80l5mua2 131 27 in in IN cord-016364-80l5mua2 131 28 some some DT cord-016364-80l5mua2 131 29 cases case NNS cord-016364-80l5mua2 131 30 requirements requirement NNS cord-016364-80l5mua2 131 31 for for IN cord-016364-80l5mua2 131 32 continuous continuous JJ cord-016364-80l5mua2 131 33 lifelong lifelong JJ cord-016364-80l5mua2 131 34 therapy therapy NN cord-016364-80l5mua2 131 35 . . . cord-016364-80l5mua2 132 1 66 66 CD cord-016364-80l5mua2 133 1 Gene gene NN cord-016364-80l5mua2 133 2 therapy therapy NN cord-016364-80l5mua2 133 3 poses pose VBZ cord-016364-80l5mua2 133 4 the the DT cord-016364-80l5mua2 133 5 most most RBS cord-016364-80l5mua2 133 6 recent recent JJ cord-016364-80l5mua2 133 7 of of IN cord-016364-80l5mua2 133 8 intervention intervention NN cord-016364-80l5mua2 133 9 strategies strategy NNS cord-016364-80l5mua2 133 10 . . . cord-016364-80l5mua2 134 1 Feline feline JJ cord-016364-80l5mua2 134 2 models model NNS cord-016364-80l5mua2 134 3 have have VBP cord-016364-80l5mua2 134 4 been be VBN cord-016364-80l5mua2 134 5 important important JJ cord-016364-80l5mua2 134 6 in in IN cord-016364-80l5mua2 134 7 elucidating elucidate VBG cord-016364-80l5mua2 134 8 molecular molecular JJ cord-016364-80l5mua2 134 9 pathogenesis pathogenesis NN cord-016364-80l5mua2 134 10 and and CC cord-016364-80l5mua2 134 11 are be VBP cord-016364-80l5mua2 134 12 now now RB cord-016364-80l5mua2 134 13 playing play VBG cord-016364-80l5mua2 134 14 a a DT cord-016364-80l5mua2 134 15 critical critical JJ cord-016364-80l5mua2 134 16 role role NN cord-016364-80l5mua2 134 17 in in IN cord-016364-80l5mua2 134 18 evaluating evaluate VBG cord-016364-80l5mua2 134 19 and and CC cord-016364-80l5mua2 134 20 optimizing optimize VBG cord-016364-80l5mua2 134 21 the the DT cord-016364-80l5mua2 134 22 range range NN cord-016364-80l5mua2 134 23 of of IN cord-016364-80l5mua2 134 24 therapeutic therapeutic JJ cord-016364-80l5mua2 134 25 strategies strategy NNS cord-016364-80l5mua2 134 26 prior prior RB cord-016364-80l5mua2 134 27 to to IN cord-016364-80l5mua2 134 28 clinical clinical JJ cord-016364-80l5mua2 134 29 trials trial NNS cord-016364-80l5mua2 134 30 in in IN cord-016364-80l5mua2 134 31 humans human NNS cord-016364-80l5mua2 134 32 . . . cord-016364-80l5mua2 135 1 The the DT cord-016364-80l5mua2 135 2 mucopolysaccharidoses mucopolysaccharidose NNS cord-016364-80l5mua2 135 3 are be VBP cord-016364-80l5mua2 135 4 disorders disorder NNS cord-016364-80l5mua2 135 5 that that WDT cord-016364-80l5mua2 135 6 result result VBP cord-016364-80l5mua2 135 7 from from IN cord-016364-80l5mua2 135 8 the the DT cord-016364-80l5mua2 135 9 defi defi NNP cord-016364-80l5mua2 135 10 ciency ciency NNP cord-016364-80l5mua2 135 11 of of IN cord-016364-80l5mua2 135 12 lysosomal lysosomal JJ cord-016364-80l5mua2 135 13 enzymes enzyme NNS cord-016364-80l5mua2 135 14 involved involve VBN cord-016364-80l5mua2 135 15 in in IN cord-016364-80l5mua2 135 16 the the DT cord-016364-80l5mua2 135 17 degradation degradation NN cord-016364-80l5mua2 135 18 of of IN cord-016364-80l5mua2 135 19 mucopolysaccharides mucopolysaccharide NNS cord-016364-80l5mua2 135 20 . . . cord-016364-80l5mua2 136 1 The the DT cord-016364-80l5mua2 136 2 cat cat NN cord-016364-80l5mua2 136 3 offers offer VBZ cord-016364-80l5mua2 136 4 homologous homologous JJ cord-016364-80l5mua2 136 5 models model NNS cord-016364-80l5mua2 136 6 for for IN cord-016364-80l5mua2 136 7 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 136 8 Types Types NNP cord-016364-80l5mua2 136 9 I I NNP cord-016364-80l5mua2 136 10 , , , cord-016364-80l5mua2 136 11 VI VI NNP cord-016364-80l5mua2 136 12 , , , cord-016364-80l5mua2 136 13 and and CC cord-016364-80l5mua2 136 14 VII VII NNP cord-016364-80l5mua2 136 15 . . . cord-016364-80l5mua2 137 1 Mucopolysaccharidosis Mucopolysaccharidosis NNP cord-016364-80l5mua2 137 2 Type type NN cord-016364-80l5mua2 137 3 I -PRON- PRP cord-016364-80l5mua2 137 4 ( ( -LRB- cord-016364-80l5mua2 137 5 MPS MPS NNP cord-016364-80l5mua2 137 6 I I NNP cord-016364-80l5mua2 137 7 ) ) -RRB- cord-016364-80l5mua2 137 8 , , , cord-016364-80l5mua2 137 9 which which WDT cord-016364-80l5mua2 137 10 results result VBZ cord-016364-80l5mua2 137 11 from from IN cord-016364-80l5mua2 137 12 a a DT cord-016364-80l5mua2 137 13 genetic genetic JJ cord-016364-80l5mua2 137 14 deficient deficient JJ cord-016364-80l5mua2 137 15 activity activity NN cord-016364-80l5mua2 137 16 of of IN cord-016364-80l5mua2 137 17 the the DT cord-016364-80l5mua2 137 18 enzyme enzyme NN cord-016364-80l5mua2 138 1 α α NNP cord-016364-80l5mua2 138 2 - - HYPH cord-016364-80l5mua2 138 3 l l NN cord-016364-80l5mua2 138 4 - - HYPH cord-016364-80l5mua2 138 5 iduronidase iduronidase NNP cord-016364-80l5mua2 138 6 ( ( -LRB- cord-016364-80l5mua2 138 7 IDUA IDUA NNP cord-016364-80l5mua2 138 8 ) ) -RRB- cord-016364-80l5mua2 138 9 , , , cord-016364-80l5mua2 138 10 can can MD cord-016364-80l5mua2 138 11 lead lead VB cord-016364-80l5mua2 138 12 to to IN cord-016364-80l5mua2 138 13 mental mental JJ cord-016364-80l5mua2 138 14 retardation retardation NN cord-016364-80l5mua2 138 15 , , , cord-016364-80l5mua2 138 16 growth growth NN cord-016364-80l5mua2 138 17 abnormalities abnormality NNS cord-016364-80l5mua2 138 18 , , , cord-016364-80l5mua2 138 19 and and CC cord-016364-80l5mua2 138 20 shortened shorten VBN cord-016364-80l5mua2 138 21 life life NN cord-016364-80l5mua2 138 22 span span VBP cord-016364-80l5mua2 138 23 in in IN cord-016364-80l5mua2 138 24 humans human NNS cord-016364-80l5mua2 138 25 . . . cord-016364-80l5mua2 139 1 67 67 CD cord-016364-80l5mua2 139 2 Naturally naturally RB cord-016364-80l5mua2 139 3 occurring occur VBG cord-016364-80l5mua2 139 4 models model NNS cord-016364-80l5mua2 139 5 have have VBP cord-016364-80l5mua2 139 6 been be VBN cord-016364-80l5mua2 139 7 characterized characterize VBN cord-016364-80l5mua2 139 8 in in IN cord-016364-80l5mua2 139 9 the the DT cord-016364-80l5mua2 139 10 cat cat NN cord-016364-80l5mua2 139 11 68,69 68,69 CD cord-016364-80l5mua2 139 12 and and CC cord-016364-80l5mua2 139 13 dog dog NN cord-016364-80l5mua2 139 14 . . . cord-016364-80l5mua2 140 1 70 70 CD cord-016364-80l5mua2 140 2 Immune immune JJ cord-016364-80l5mua2 140 3 responses response NNS cord-016364-80l5mua2 140 4 can can MD cord-016364-80l5mua2 140 5 nullify nullify VB cord-016364-80l5mua2 140 6 the the DT cord-016364-80l5mua2 140 7 effect effect NN cord-016364-80l5mua2 140 8 of of IN cord-016364-80l5mua2 140 9 gene gene NN cord-016364-80l5mua2 140 10 corrective corrective JJ cord-016364-80l5mua2 140 11 therapy therapy NN cord-016364-80l5mua2 140 12 . . . cord-016364-80l5mua2 141 1 It -PRON- PRP cord-016364-80l5mua2 141 2 has have VBZ cord-016364-80l5mua2 141 3 been be VBN cord-016364-80l5mua2 141 4 demonstrated demonstrate VBN cord-016364-80l5mua2 141 5 that that IN cord-016364-80l5mua2 141 6 cats cat NNS cord-016364-80l5mua2 141 7 , , , cord-016364-80l5mua2 141 8 but but CC cord-016364-80l5mua2 141 9 not not RB cord-016364-80l5mua2 141 10 dogs dog NNS cord-016364-80l5mua2 141 11 , , , cord-016364-80l5mua2 141 12 mount mount VBP cord-016364-80l5mua2 141 13 a a DT cord-016364-80l5mua2 141 14 potent potent JJ cord-016364-80l5mua2 141 15 CTL CTL NNP cord-016364-80l5mua2 141 16 response response NN cord-016364-80l5mua2 141 17 to to IN cord-016364-80l5mua2 141 18 canine canine JJ cord-016364-80l5mua2 141 19 IDUA idua NN cord-016364-80l5mua2 141 20 after after IN cord-016364-80l5mua2 141 21 neonatal neonatal JJ cord-016364-80l5mua2 141 22 gene gene NN cord-016364-80l5mua2 141 23 therapy therapy NN cord-016364-80l5mua2 141 24 , , , cord-016364-80l5mua2 141 25 which which WDT cord-016364-80l5mua2 141 26 can can MD cord-016364-80l5mua2 141 27 be be VB cord-016364-80l5mua2 141 28 prevented prevent VBN cord-016364-80l5mua2 141 29 with with IN cord-016364-80l5mua2 141 30 transient transient JJ cord-016364-80l5mua2 141 31 CTLA4-Ig CTLA4-Ig NNP cord-016364-80l5mua2 141 32 . . . cord-016364-80l5mua2 142 1 71 71 CD cord-016364-80l5mua2 143 1 The the DT cord-016364-80l5mua2 143 2 efficacy efficacy NN cord-016364-80l5mua2 143 3 of of IN cord-016364-80l5mua2 143 4 neonatal neonatal JJ cord-016364-80l5mua2 143 5 retroviral retroviral NN cord-016364-80l5mua2 143 6 therapy therapy NN cord-016364-80l5mua2 143 7 has have VBZ cord-016364-80l5mua2 143 8 also also RB cord-016364-80l5mua2 143 9 been be VBN cord-016364-80l5mua2 143 10 explored explore VBN cord-016364-80l5mua2 143 11 in in IN cord-016364-80l5mua2 143 12 the the DT cord-016364-80l5mua2 143 13 cat cat NN cord-016364-80l5mua2 143 14 . . . cord-016364-80l5mua2 144 1 66 66 CD cord-016364-80l5mua2 145 1 The the DT cord-016364-80l5mua2 145 2 cat cat NN cord-016364-80l5mua2 145 3 model model NN cord-016364-80l5mua2 145 4 , , , cord-016364-80l5mua2 145 5 additionally additionally RB cord-016364-80l5mua2 145 6 , , , cord-016364-80l5mua2 145 7 provides provide VBZ cord-016364-80l5mua2 145 8 an an DT cord-016364-80l5mua2 145 9 ideal ideal JJ cord-016364-80l5mua2 145 10 system system NN cord-016364-80l5mua2 145 11 to to TO cord-016364-80l5mua2 145 12 study study VB cord-016364-80l5mua2 145 13 mechanisms mechanism NNS cord-016364-80l5mua2 145 14 of of IN cord-016364-80l5mua2 145 15 brain brain NN cord-016364-80l5mua2 145 16 neurodegeneration neurodegeneration NN cord-016364-80l5mua2 145 17 and and CC cord-016364-80l5mua2 145 18 neural neural NN cord-016364-80l5mua2 145 19 - - HYPH cord-016364-80l5mua2 145 20 directed direct VBN cord-016364-80l5mua2 145 21 strategies strategy NNS cord-016364-80l5mua2 145 22 , , , cord-016364-80l5mua2 145 23 especially especially RB cord-016364-80l5mua2 145 24 given give VBN cord-016364-80l5mua2 145 25 a a DT cord-016364-80l5mua2 145 26 large large JJ cord-016364-80l5mua2 145 27 body body NN cord-016364-80l5mua2 145 28 of of IN cord-016364-80l5mua2 145 29 preexisting preexist VBG cord-016364-80l5mua2 145 30 literature literature NN cord-016364-80l5mua2 145 31 on on IN cord-016364-80l5mua2 145 32 cat cat NNP cord-016364-80l5mua2 145 33 neurology neurology NNP cord-016364-80l5mua2 145 34 . . . cord-016364-80l5mua2 146 1 MPS MPS NNP cord-016364-80l5mua2 146 2 VI VI NNP cord-016364-80l5mua2 146 3 or or CC cord-016364-80l5mua2 146 4 Marteaux Marteaux NNP cord-016364-80l5mua2 146 5 - - HYPH cord-016364-80l5mua2 146 6 Lamy Lamy NNP cord-016364-80l5mua2 146 7 disease disease NN cord-016364-80l5mua2 146 8 , , , cord-016364-80l5mua2 146 9 deficient deficient JJ cord-016364-80l5mua2 146 10 activity activity NN cord-016364-80l5mua2 146 11 of of IN cord-016364-80l5mua2 146 12 arylsulfatase arylsulfatase NNP cord-016364-80l5mua2 146 13 B B NNP cord-016364-80l5mua2 146 14 ( ( -LRB- cord-016364-80l5mua2 146 15 ARSB ARSB NNP cord-016364-80l5mua2 146 16 ) ) -RRB- cord-016364-80l5mua2 146 17 , , , cord-016364-80l5mua2 146 18 is be VBZ cord-016364-80l5mua2 146 19 characterized characterize VBN cord-016364-80l5mua2 146 20 in in IN cord-016364-80l5mua2 146 21 humans human NNS cord-016364-80l5mua2 146 22 and and CC cord-016364-80l5mua2 146 23 cats cat NNS cord-016364-80l5mua2 146 24 with with IN cord-016364-80l5mua2 146 25 growth growth NN cord-016364-80l5mua2 146 26 retardation retardation NN cord-016364-80l5mua2 146 27 , , , cord-016364-80l5mua2 146 28 coarse coarse JJ cord-016364-80l5mua2 146 29 facial facial JJ cord-016364-80l5mua2 146 30 features feature NNS cord-016364-80l5mua2 146 31 , , , cord-016364-80l5mua2 146 32 corneal corneal JJ cord-016364-80l5mua2 146 33 opacity opacity NN cord-016364-80l5mua2 146 34 , , , cord-016364-80l5mua2 146 35 and and CC cord-016364-80l5mua2 146 36 skeletal skeletal JJ cord-016364-80l5mua2 146 37 deformities deformity NNS cord-016364-80l5mua2 146 38 . . . cord-016364-80l5mua2 147 1 [ [ -LRB- cord-016364-80l5mua2 147 2 72 72 CD cord-016364-80l5mua2 147 3 ] ] -RRB- cord-016364-80l5mua2 147 4 [ [ -LRB- cord-016364-80l5mua2 147 5 73 73 CD cord-016364-80l5mua2 147 6 ] ] -RRB- cord-016364-80l5mua2 147 7 [ [ -LRB- cord-016364-80l5mua2 147 8 74 74 CD cord-016364-80l5mua2 147 9 ] ] -RRB- cord-016364-80l5mua2 148 1 [ [ -LRB- cord-016364-80l5mua2 148 2 75 75 CD cord-016364-80l5mua2 148 3 ] ] -RRB- cord-016364-80l5mua2 149 1 The the DT cord-016364-80l5mua2 149 2 feline feline JJ cord-016364-80l5mua2 149 3 model model NN cord-016364-80l5mua2 149 4 also also RB cord-016364-80l5mua2 149 5 exhibits exhibit VBZ cord-016364-80l5mua2 149 6 abnormal abnormal JJ cord-016364-80l5mua2 149 7 lysosomal lysosomal JJ cord-016364-80l5mua2 149 8 storage storage NN cord-016364-80l5mua2 149 9 in in IN cord-016364-80l5mua2 149 10 occasional occasional JJ cord-016364-80l5mua2 149 11 neurons neuron NNS cord-016364-80l5mua2 149 12 and and CC cord-016364-80l5mua2 149 13 glia glia NNS cord-016364-80l5mua2 149 14 distributed distribute VBN cord-016364-80l5mua2 149 15 throughout throughout IN cord-016364-80l5mua2 149 16 the the DT cord-016364-80l5mua2 149 17 cerebral cerebral JJ cord-016364-80l5mua2 149 18 cortex cortex NN cord-016364-80l5mua2 149 19 . . . cord-016364-80l5mua2 150 1 76 76 CD cord-016364-80l5mua2 150 2 Fibroblast Fibroblast NNP cord-016364-80l5mua2 150 3 - - HYPH cord-016364-80l5mua2 150 4 mediated mediate VBN cord-016364-80l5mua2 150 5 in in IN cord-016364-80l5mua2 150 6 vitro vitro FW cord-016364-80l5mua2 150 7 gene gene NN cord-016364-80l5mua2 150 8 therapy therapy NN cord-016364-80l5mua2 150 9 has have VBZ cord-016364-80l5mua2 150 10 been be VBN cord-016364-80l5mua2 150 11 examined examine VBN cord-016364-80l5mua2 150 12 in in IN cord-016364-80l5mua2 150 13 this this DT cord-016364-80l5mua2 150 14 cat cat NN cord-016364-80l5mua2 150 15 model model NN cord-016364-80l5mua2 150 16 . . . cord-016364-80l5mua2 151 1 77 77 CD cord-016364-80l5mua2 152 1 Recently recently RB cord-016364-80l5mua2 152 2 , , , cord-016364-80l5mua2 152 3 an an DT cord-016364-80l5mua2 152 4 adeno adeno NN cord-016364-80l5mua2 152 5 - - HYPH cord-016364-80l5mua2 152 6 associated associate VBN cord-016364-80l5mua2 152 7 vector vector NN cord-016364-80l5mua2 152 8 containing contain VBG cord-016364-80l5mua2 152 9 feline feline JJ cord-016364-80l5mua2 152 10 ARSB ARSB NNP cord-016364-80l5mua2 152 11 has have VBZ cord-016364-80l5mua2 152 12 demonstrated demonstrate VBN cord-016364-80l5mua2 152 13 gene gene NN cord-016364-80l5mua2 152 14 therapy therapy NN cord-016364-80l5mua2 152 15 - - HYPH cord-016364-80l5mua2 152 16 based base VBN cord-016364-80l5mua2 152 17 correction correction NN cord-016364-80l5mua2 152 18 of of IN cord-016364-80l5mua2 152 19 corneal corneal JJ cord-016364-80l5mua2 152 20 clouding clouding NN cord-016364-80l5mua2 152 21 in in IN cord-016364-80l5mua2 152 22 the the DT cord-016364-80l5mua2 152 23 MPS MPS NNP cord-016364-80l5mua2 152 24 VI VI NNP cord-016364-80l5mua2 152 25 cat cat NN cord-016364-80l5mua2 152 26 . . . cord-016364-80l5mua2 153 1 78 78 CD cord-016364-80l5mua2 154 1 MPS MPS NNP cord-016364-80l5mua2 154 2 VII VII NNP cord-016364-80l5mua2 154 3 results result VBZ cord-016364-80l5mua2 154 4 from from IN cord-016364-80l5mua2 154 5 deficiency deficiency NN cord-016364-80l5mua2 154 6 of of IN cord-016364-80l5mua2 154 7 β β NN cord-016364-80l5mua2 154 8 - - HYPH cord-016364-80l5mua2 154 9 glucuronidase glucuronidase NNP cord-016364-80l5mua2 154 10 ( ( -LRB- cord-016364-80l5mua2 154 11 GUSB GUSB NNP cord-016364-80l5mua2 154 12 ) ) -RRB- cord-016364-80l5mua2 154 13 , , , cord-016364-80l5mua2 154 14 which which WDT cord-016364-80l5mua2 154 15 in in IN cord-016364-80l5mua2 154 16 humans human NNS cord-016364-80l5mua2 154 17 manifests manifest VBZ cord-016364-80l5mua2 154 18 as as IN cord-016364-80l5mua2 154 19 cartilaginous cartilaginous JJ cord-016364-80l5mua2 154 20 and and CC cord-016364-80l5mua2 154 21 bony bony JJ cord-016364-80l5mua2 154 22 malformations malformation NNS cord-016364-80l5mua2 154 23 , , , cord-016364-80l5mua2 154 24 growth growth NN cord-016364-80l5mua2 154 25 and and CC cord-016364-80l5mua2 154 26 mental mental JJ cord-016364-80l5mua2 154 27 retardation retardation NN cord-016364-80l5mua2 154 28 , , , cord-016364-80l5mua2 154 29 abdominal abdominal JJ cord-016364-80l5mua2 154 30 organ organ NN cord-016364-80l5mua2 154 31 enlargement enlargement NN cord-016364-80l5mua2 154 32 , , , cord-016364-80l5mua2 154 33 and and CC cord-016364-80l5mua2 154 34 corneal corneal JJ cord-016364-80l5mua2 154 35 clouding clouding NN cord-016364-80l5mua2 154 36 . . . cord-016364-80l5mua2 155 1 79 79 CD cord-016364-80l5mua2 155 2 Naturally naturally RB cord-016364-80l5mua2 155 3 occurring occur VBG cord-016364-80l5mua2 155 4 animal animal NN cord-016364-80l5mua2 155 5 models model NNS cord-016364-80l5mua2 155 6 have have VBP cord-016364-80l5mua2 155 7 been be VBN cord-016364-80l5mua2 155 8 described describe VBN cord-016364-80l5mua2 155 9 in in IN cord-016364-80l5mua2 155 10 mice mouse NNS cord-016364-80l5mua2 155 11 , , , cord-016364-80l5mua2 155 12 80 80 CD cord-016364-80l5mua2 155 13 dogs dog NNS cord-016364-80l5mua2 155 14 , , , cord-016364-80l5mua2 155 15 81 81 CD cord-016364-80l5mua2 155 16 and and CC cord-016364-80l5mua2 155 17 the the DT cord-016364-80l5mua2 155 18 cat cat NN cord-016364-80l5mua2 155 19 . . . cord-016364-80l5mua2 156 1 82 82 CD cord-016364-80l5mua2 156 2 Enzymatic enzymatic JJ cord-016364-80l5mua2 156 3 activity activity NN cord-016364-80l5mua2 156 4 has have VBZ cord-016364-80l5mua2 156 5 been be VBN cord-016364-80l5mua2 156 6 restored restore VBN cord-016364-80l5mua2 156 7 in in IN cord-016364-80l5mua2 156 8 fibroblasts fibroblast NNS cord-016364-80l5mua2 156 9 and and CC cord-016364-80l5mua2 156 10 restored restore VBN cord-016364-80l5mua2 156 11 by by IN cord-016364-80l5mua2 156 12 retroviral retroviral JJ cord-016364-80l5mua2 156 13 gene gene NN cord-016364-80l5mua2 156 14 transfer transfer NN cord-016364-80l5mua2 156 15 of of IN cord-016364-80l5mua2 156 16 rat rat NN cord-016364-80l5mua2 156 17 GUSB GUSB NNP cord-016364-80l5mua2 156 18 cDNA cdna NN cord-016364-80l5mua2 156 19 . . . cord-016364-80l5mua2 157 1 As as IN cord-016364-80l5mua2 157 2 GUSB GUSB NNP cord-016364-80l5mua2 157 3 is be VBZ cord-016364-80l5mua2 157 4 an an DT cord-016364-80l5mua2 157 5 essential essential JJ cord-016364-80l5mua2 157 6 housekeeping housekeeping NN cord-016364-80l5mua2 157 7 enzyme enzyme NN cord-016364-80l5mua2 157 8 , , , cord-016364-80l5mua2 157 9 this this DT cord-016364-80l5mua2 157 10 feline feline JJ cord-016364-80l5mua2 157 11 model model NN cord-016364-80l5mua2 157 12 is be VBZ cord-016364-80l5mua2 157 13 important important JJ cord-016364-80l5mua2 157 14 for for IN cord-016364-80l5mua2 157 15 examination examination NN cord-016364-80l5mua2 157 16 of of IN cord-016364-80l5mua2 157 17 exogenous exogenous JJ cord-016364-80l5mua2 157 18 genes gene NNS cord-016364-80l5mua2 157 19 and and CC cord-016364-80l5mua2 157 20 gene gene NN cord-016364-80l5mua2 157 21 product product NN cord-016364-80l5mua2 157 22 delivery delivery NN cord-016364-80l5mua2 157 23 to to IN cord-016364-80l5mua2 157 24 a a DT cord-016364-80l5mua2 157 25 variety variety NN cord-016364-80l5mua2 157 26 of of IN cord-016364-80l5mua2 157 27 tissue tissue NN cord-016364-80l5mua2 157 28 types type NNS cord-016364-80l5mua2 157 29 , , , cord-016364-80l5mua2 157 30 and and CC cord-016364-80l5mua2 157 31 could could MD cord-016364-80l5mua2 157 32 prove prove VB cord-016364-80l5mua2 157 33 especially especially RB cord-016364-80l5mua2 157 34 valuable valuable JJ cord-016364-80l5mua2 157 35 due due IN cord-016364-80l5mua2 157 36 to to IN cord-016364-80l5mua2 157 37 extensive extensive JJ cord-016364-80l5mua2 157 38 research research NN cord-016364-80l5mua2 157 39 conducted conduct VBN cord-016364-80l5mua2 157 40 on on IN cord-016364-80l5mua2 157 41 the the DT cord-016364-80l5mua2 157 42 anatomy anatomy NN cord-016364-80l5mua2 157 43 and and CC cord-016364-80l5mua2 157 44 physiology physiology NN cord-016364-80l5mua2 157 45 of of IN cord-016364-80l5mua2 157 46 the the DT cord-016364-80l5mua2 157 47 cat cat NN cord-016364-80l5mua2 157 48 central central JJ cord-016364-80l5mua2 157 49 nervous nervous JJ cord-016364-80l5mua2 157 50 and and CC cord-016364-80l5mua2 157 51 visual visual JJ cord-016364-80l5mua2 157 52 systems system NNS cord-016364-80l5mua2 157 53 . . . cord-016364-80l5mua2 158 1 Three three CD cord-016364-80l5mua2 158 2 different different JJ cord-016364-80l5mua2 158 3 serotypes serotype NNS cord-016364-80l5mua2 158 4 of of IN cord-016364-80l5mua2 158 5 adeno adeno NN cord-016364-80l5mua2 158 6 - - HYPH cord-016364-80l5mua2 158 7 associated associate VBN cord-016364-80l5mua2 158 8 viral viral JJ cord-016364-80l5mua2 158 9 constructs construct NNS cord-016364-80l5mua2 158 10 of of IN cord-016364-80l5mua2 158 11 GUSB GUSB NNP cord-016364-80l5mua2 158 12 demonstrated demonstrate VBD cord-016364-80l5mua2 158 13 the the DT cord-016364-80l5mua2 158 14 efficacy efficacy NN cord-016364-80l5mua2 158 15 of of IN cord-016364-80l5mua2 158 16 this this DT cord-016364-80l5mua2 158 17 vector vector NN cord-016364-80l5mua2 158 18 to to TO cord-016364-80l5mua2 158 19 achieve achieve VB cord-016364-80l5mua2 158 20 gene gene NN cord-016364-80l5mua2 158 21 transfer transfer NN cord-016364-80l5mua2 158 22 in in IN cord-016364-80l5mua2 158 23 the the DT cord-016364-80l5mua2 158 24 normal normal JJ cord-016364-80l5mua2 158 25 cat cat NN cord-016364-80l5mua2 158 26 brain brain NN cord-016364-80l5mua2 158 27 , , , cord-016364-80l5mua2 158 28 as as IN cord-016364-80l5mua2 158 29 a a DT cord-016364-80l5mua2 158 30 model model NN cord-016364-80l5mua2 158 31 for for IN cord-016364-80l5mua2 158 32 the the DT cord-016364-80l5mua2 158 33 efficacy efficacy NN cord-016364-80l5mua2 158 34 of of IN cord-016364-80l5mua2 158 35 this this DT cord-016364-80l5mua2 158 36 construct construct NN cord-016364-80l5mua2 158 37 in in IN cord-016364-80l5mua2 158 38 a a DT cord-016364-80l5mua2 158 39 large large JJ cord-016364-80l5mua2 158 40 mammalian mammalian JJ cord-016364-80l5mua2 158 41 brain brain NN cord-016364-80l5mua2 158 42 . . . cord-016364-80l5mua2 159 1 83 83 CD cord-016364-80l5mua2 159 2 Defi Defi NNP cord-016364-80l5mua2 159 3 ciency ciency NN cord-016364-80l5mua2 159 4 of of IN cord-016364-80l5mua2 159 5 lysosomal lysosomal JJ cord-016364-80l5mua2 159 6 α α NN cord-016364-80l5mua2 159 7 - - HYPH cord-016364-80l5mua2 159 8 mannosidase mannosidase NN cord-016364-80l5mua2 159 9 leads lead VBZ cord-016364-80l5mua2 159 10 to to IN cord-016364-80l5mua2 159 11 an an DT cord-016364-80l5mua2 159 12 accumulation accumulation NN cord-016364-80l5mua2 159 13 of of IN cord-016364-80l5mua2 159 14 mannose mannose NN cord-016364-80l5mua2 159 15 - - HYPH cord-016364-80l5mua2 159 16 rich rich JJ cord-016364-80l5mua2 159 17 oligosaccharides oligosaccharide NNS cord-016364-80l5mua2 159 18 , , , cord-016364-80l5mua2 159 19 84 84 CD cord-016364-80l5mua2 159 20 which which WDT cord-016364-80l5mua2 159 21 leads lead VBZ cord-016364-80l5mua2 159 22 to to IN cord-016364-80l5mua2 159 23 mental mental JJ cord-016364-80l5mua2 159 24 retardation retardation NN cord-016364-80l5mua2 159 25 , , , cord-016364-80l5mua2 159 26 recurrent recurrent JJ cord-016364-80l5mua2 159 27 infections infection NNS cord-016364-80l5mua2 159 28 , , , cord-016364-80l5mua2 159 29 skeletal skeletal JJ cord-016364-80l5mua2 159 30 changes change NNS cord-016364-80l5mua2 159 31 and and CC cord-016364-80l5mua2 159 32 hearing hearing NN cord-016364-80l5mua2 159 33 impairment impairment NN cord-016364-80l5mua2 159 34 . . . cord-016364-80l5mua2 160 1 85 85 CD cord-016364-80l5mua2 161 1 This this DT cord-016364-80l5mua2 161 2 feline feline JJ cord-016364-80l5mua2 161 3 model model NN cord-016364-80l5mua2 161 4 was be VBD cord-016364-80l5mua2 161 5 initially initially RB cord-016364-80l5mua2 161 6 important important JJ cord-016364-80l5mua2 161 7 in in IN cord-016364-80l5mua2 161 8 achieving achieve VBG cord-016364-80l5mua2 161 9 bone bone NN cord-016364-80l5mua2 161 10 marrow marrow NN cord-016364-80l5mua2 161 11 transplantation transplantation NN cord-016364-80l5mua2 161 12 as as IN cord-016364-80l5mua2 161 13 corrective corrective JJ cord-016364-80l5mua2 161 14 strategy strategy NN cord-016364-80l5mua2 161 15 for for IN cord-016364-80l5mua2 161 16 neuronal neuronal JJ cord-016364-80l5mua2 161 17 storage storage NN cord-016364-80l5mua2 161 18 diseases disease NNS cord-016364-80l5mua2 161 19 of of IN cord-016364-80l5mua2 161 20 the the DT cord-016364-80l5mua2 161 21 CNS CNS NNP cord-016364-80l5mua2 161 22 . . . cord-016364-80l5mua2 162 1 86 86 CD cord-016364-80l5mua2 162 2 , , , cord-016364-80l5mua2 162 3 87 87 CD cord-016364-80l5mua2 163 1 Recently recently RB cord-016364-80l5mua2 163 2 , , , cord-016364-80l5mua2 163 3 adeno adeno NN cord-016364-80l5mua2 163 4 - - HYPH cord-016364-80l5mua2 163 5 associated associate VBN cord-016364-80l5mua2 163 6 viral viral NN cord-016364-80l5mua2 163 7 ( ( -LRB- cord-016364-80l5mua2 163 8 AAV AAV NNP cord-016364-80l5mua2 163 9 ) ) -RRB- cord-016364-80l5mua2 163 10 constructs construct NNS cord-016364-80l5mua2 163 11 of of IN cord-016364-80l5mua2 163 12 feline feline JJ cord-016364-80l5mua2 163 13 α α NN cord-016364-80l5mua2 163 14 - - HYPH cord-016364-80l5mua2 163 15 mannosidase mannosidase NNP cord-016364-80l5mua2 163 16 were be VBD cord-016364-80l5mua2 163 17 used use VBN cord-016364-80l5mua2 163 18 to to TO cord-016364-80l5mua2 163 19 demonstrate demonstrate VB cord-016364-80l5mua2 163 20 the the DT cord-016364-80l5mua2 163 21 efficacy efficacy NN cord-016364-80l5mua2 163 22 of of IN cord-016364-80l5mua2 163 23 CNS CNS NNP cord-016364-80l5mua2 163 24 gene gene NN cord-016364-80l5mua2 163 25 therapy therapy NN cord-016364-80l5mua2 163 26 . . . cord-016364-80l5mua2 164 1 Treated treat VBN cord-016364-80l5mua2 164 2 cats cat NNS cord-016364-80l5mua2 164 3 exhibited exhibit VBD cord-016364-80l5mua2 164 4 widespread widespread JJ cord-016364-80l5mua2 164 5 improvement improvement NN cord-016364-80l5mua2 164 6 of of IN cord-016364-80l5mua2 164 7 neuropathology neuropathology NN cord-016364-80l5mua2 164 8 , , , cord-016364-80l5mua2 164 9 showing show VBG cord-016364-80l5mua2 164 10 the the DT cord-016364-80l5mua2 164 11 effi effi NNP cord-016364-80l5mua2 164 12 cacy cacy NN cord-016364-80l5mua2 164 13 of of IN cord-016364-80l5mua2 164 14 this this DT cord-016364-80l5mua2 164 15 treatment treatment NN cord-016364-80l5mua2 164 16 in in IN cord-016364-80l5mua2 164 17 a a DT cord-016364-80l5mua2 164 18 large large JJ cord-016364-80l5mua2 164 19 mammalian mammalian JJ cord-016364-80l5mua2 164 20 brain brain NN cord-016364-80l5mua2 164 21 for for IN cord-016364-80l5mua2 164 22 CNS CNS NNP cord-016364-80l5mua2 164 23 correction correction NN cord-016364-80l5mua2 164 24 of of IN cord-016364-80l5mua2 164 25 human human JJ cord-016364-80l5mua2 164 26 lysosomal lysosomal JJ cord-016364-80l5mua2 164 27 enzyme enzyme NN cord-016364-80l5mua2 164 28 defi defi NNP cord-016364-80l5mua2 164 29 ciencies ciencies NNP cord-016364-80l5mua2 164 30 . . . cord-016364-80l5mua2 165 1 88 88 CD cord-016364-80l5mua2 165 2 Lipoprotein lipoprotein NN cord-016364-80l5mua2 165 3 lipase lipase NN cord-016364-80l5mua2 165 4 ( ( -LRB- cord-016364-80l5mua2 165 5 LPL LPL NNP cord-016364-80l5mua2 165 6 ) ) -RRB- cord-016364-80l5mua2 165 7 is be VBZ cord-016364-80l5mua2 165 8 a a DT cord-016364-80l5mua2 165 9 crucial crucial JJ cord-016364-80l5mua2 165 10 enzyme enzyme NN cord-016364-80l5mua2 165 11 involved involve VBN cord-016364-80l5mua2 165 12 in in IN cord-016364-80l5mua2 165 13 the the DT cord-016364-80l5mua2 165 14 regulation regulation NN cord-016364-80l5mua2 165 15 of of IN cord-016364-80l5mua2 165 16 lipoprotein lipoprotein NN cord-016364-80l5mua2 165 17 and and CC cord-016364-80l5mua2 165 18 lipid lipid NN cord-016364-80l5mua2 165 19 metabolism metabolism NN cord-016364-80l5mua2 165 20 ability ability NN cord-016364-80l5mua2 165 21 to to TO cord-016364-80l5mua2 165 22 thrive thrive VB cord-016364-80l5mua2 165 23 . . . cord-016364-80l5mua2 166 1 89 89 CD cord-016364-80l5mua2 166 2 Cats cat NNS cord-016364-80l5mua2 166 3 with with IN cord-016364-80l5mua2 166 4 LPL LPL NNP cord-016364-80l5mua2 166 5 deficiency deficiency NN cord-016364-80l5mua2 166 6 display display NN cord-016364-80l5mua2 166 7 a a DT cord-016364-80l5mua2 166 8 remarkably remarkably RB cord-016364-80l5mua2 166 9 similar similar JJ cord-016364-80l5mua2 166 10 phenotype phenotype NN cord-016364-80l5mua2 166 11 to to IN cord-016364-80l5mua2 166 12 humans human NNS cord-016364-80l5mua2 166 13 , , , cord-016364-80l5mua2 166 14 including include VBG cord-016364-80l5mua2 166 15 severe severe JJ cord-016364-80l5mua2 166 16 pancreatitis pancreatitis NN cord-016364-80l5mua2 166 17 , , , cord-016364-80l5mua2 166 18 chylomicronemia chylomicronemia NN cord-016364-80l5mua2 166 19 , , , cord-016364-80l5mua2 166 20 and and CC cord-016364-80l5mua2 166 21 failure failure NN cord-016364-80l5mua2 166 22 to to TO cord-016364-80l5mua2 166 23 thrive thrive VB cord-016364-80l5mua2 166 24 . . . cord-016364-80l5mua2 167 1 46 46 CD cord-016364-80l5mua2 168 1 There there EX cord-016364-80l5mua2 168 2 is be VBZ cord-016364-80l5mua2 168 3 currently currently RB cord-016364-80l5mua2 168 4 no no DT cord-016364-80l5mua2 168 5 adequate adequate JJ cord-016364-80l5mua2 168 6 treatment treatment NN cord-016364-80l5mua2 168 7 for for IN cord-016364-80l5mua2 168 8 this this DT cord-016364-80l5mua2 168 9 pathology pathology NN cord-016364-80l5mua2 168 10 in in IN cord-016364-80l5mua2 168 11 humans human NNS cord-016364-80l5mua2 168 12 . . . cord-016364-80l5mua2 169 1 Cats cat NNS cord-016364-80l5mua2 169 2 could could MD cord-016364-80l5mua2 169 3 prove prove VB cord-016364-80l5mua2 169 4 to to TO cord-016364-80l5mua2 169 5 be be VB cord-016364-80l5mua2 169 6 the the DT cord-016364-80l5mua2 169 7 most most RBS cord-016364-80l5mua2 169 8 valuable valuable JJ cord-016364-80l5mua2 169 9 animal animal NN cord-016364-80l5mua2 169 10 model model NN cord-016364-80l5mua2 169 11 of of IN cord-016364-80l5mua2 169 12 LPL LPL NNP cord-016364-80l5mua2 169 13 deficiency deficiency NN cord-016364-80l5mua2 169 14 , , , cord-016364-80l5mua2 169 15 as as IN cord-016364-80l5mua2 169 16 of of IN cord-016364-80l5mua2 169 17 numerous numerous JJ cord-016364-80l5mua2 169 18 animal animal NN cord-016364-80l5mua2 169 19 model model NN cord-016364-80l5mua2 169 20 systems system NNS cord-016364-80l5mua2 169 21 examined examine VBD cord-016364-80l5mua2 169 22 including include VBG cord-016364-80l5mua2 169 23 the the DT cord-016364-80l5mua2 169 24 mouse mouse NN cord-016364-80l5mua2 169 25 , , , cord-016364-80l5mua2 169 26 the the DT cord-016364-80l5mua2 169 27 cat cat NN cord-016364-80l5mua2 169 28 most most RBS cord-016364-80l5mua2 169 29 closely closely RB cord-016364-80l5mua2 169 30 resembles resemble VBZ cord-016364-80l5mua2 169 31 the the DT cord-016364-80l5mua2 169 32 lipoprotein lipoprotein NN cord-016364-80l5mua2 169 33 pattern pattern NN cord-016364-80l5mua2 169 34 and and CC cord-016364-80l5mua2 169 35 lipid lipid NN cord-016364-80l5mua2 169 36 transport transport NN cord-016364-80l5mua2 169 37 system system NN cord-016364-80l5mua2 169 38 of of IN cord-016364-80l5mua2 169 39 humans human NNS cord-016364-80l5mua2 169 40 . . . cord-016364-80l5mua2 170 1 Recently recently RB cord-016364-80l5mua2 170 2 , , , cord-016364-80l5mua2 170 3 AAV AAV NNP cord-016364-80l5mua2 170 4 - - HYPH cord-016364-80l5mua2 170 5 mediated mediate VBN cord-016364-80l5mua2 170 6 transfer transfer NN cord-016364-80l5mua2 170 7 of of IN cord-016364-80l5mua2 170 8 a a DT cord-016364-80l5mua2 170 9 human human JJ cord-016364-80l5mua2 170 10 LPL LPL NNP cord-016364-80l5mua2 170 11 S447X S447X NNP cord-016364-80l5mua2 170 12 variant variant NN cord-016364-80l5mua2 170 13 into into IN cord-016364-80l5mua2 170 14 feline feline JJ cord-016364-80l5mua2 170 15 muscle muscle NN cord-016364-80l5mua2 170 16 cells cell NNS cord-016364-80l5mua2 170 17 demonstrated demonstrate VBD cord-016364-80l5mua2 170 18 correction correction NN cord-016364-80l5mua2 170 19 of of IN cord-016364-80l5mua2 170 20 the the DT cord-016364-80l5mua2 170 21 hypertriglyceridemia hypertriglyceridemia NN cord-016364-80l5mua2 170 22 associated associate VBN cord-016364-80l5mua2 170 23 with with IN cord-016364-80l5mua2 170 24 feline feline JJ cord-016364-80l5mua2 170 25 pathology pathology NN cord-016364-80l5mua2 170 26 ; ; : cord-016364-80l5mua2 170 27 this this DT cord-016364-80l5mua2 170 28 offers offer VBZ cord-016364-80l5mua2 170 29 much much JJ cord-016364-80l5mua2 170 30 promise promise NN cord-016364-80l5mua2 170 31 for for IN cord-016364-80l5mua2 170 32 treatment treatment NN cord-016364-80l5mua2 170 33 of of IN cord-016364-80l5mua2 170 34 human human JJ cord-016364-80l5mua2 170 35 LPL LPL NNP cord-016364-80l5mua2 170 36 defi defi NNP cord-016364-80l5mua2 170 37 ciency ciency NNP cord-016364-80l5mua2 170 38 . . . cord-016364-80l5mua2 171 1 90 90 CD cord-016364-80l5mua2 172 1 A a DT cord-016364-80l5mua2 172 2 separate separate JJ cord-016364-80l5mua2 172 3 class class NN cord-016364-80l5mua2 172 4 of of IN cord-016364-80l5mua2 172 5 lysosomal lysosomal JJ cord-016364-80l5mua2 172 6 storage storage NN cord-016364-80l5mua2 172 7 disorder disorder NN cord-016364-80l5mua2 172 8 characterized characterize VBN cord-016364-80l5mua2 172 9 in in IN cord-016364-80l5mua2 172 10 the the DT cord-016364-80l5mua2 172 11 cat cat NN cord-016364-80l5mua2 172 12 is be VBZ cord-016364-80l5mua2 172 13 the the DT cord-016364-80l5mua2 172 14 gangliosidoses gangliosidose NNS cord-016364-80l5mua2 172 15 , , , cord-016364-80l5mua2 172 16 G G NNP cord-016364-80l5mua2 172 17 M1 M1 NNP cord-016364-80l5mua2 172 18 and and CC cord-016364-80l5mua2 172 19 G G NNP cord-016364-80l5mua2 172 20 M2 M2 NNP cord-016364-80l5mua2 172 21 , , , cord-016364-80l5mua2 172 22 which which WDT cord-016364-80l5mua2 172 23 are be VBP cord-016364-80l5mua2 172 24 heritable heritable JJ cord-016364-80l5mua2 172 25 neurodegenerative neurodegenerative JJ cord-016364-80l5mua2 172 26 diseases disease NNS cord-016364-80l5mua2 172 27 . . . cord-016364-80l5mua2 173 1 A a DT cord-016364-80l5mua2 173 2 deficiency deficiency NN cord-016364-80l5mua2 173 3 of of IN cord-016364-80l5mua2 173 4 lysosomal lysosomal JJ cord-016364-80l5mua2 173 5 β β NN cord-016364-80l5mua2 173 6 - - HYPH cord-016364-80l5mua2 173 7 galactosidase galactosidase NN cord-016364-80l5mua2 173 8 results result NNS cord-016364-80l5mua2 173 9 in in IN cord-016364-80l5mua2 173 10 the the DT cord-016364-80l5mua2 173 11 neuronal neuronal JJ cord-016364-80l5mua2 173 12 accumulation accumulation NN cord-016364-80l5mua2 173 13 of of IN cord-016364-80l5mua2 173 14 the the DT cord-016364-80l5mua2 173 15 G G NNP cord-016364-80l5mua2 173 16 M1 M1 NNP cord-016364-80l5mua2 173 17 ganglioside ganglioside NN cord-016364-80l5mua2 173 18 , , , cord-016364-80l5mua2 173 19 while while IN cord-016364-80l5mua2 173 20 the the DT cord-016364-80l5mua2 173 21 degradation degradation NN cord-016364-80l5mua2 173 22 of of IN cord-016364-80l5mua2 173 23 the the DT cord-016364-80l5mua2 173 24 G G NNP cord-016364-80l5mua2 173 25 M2 M2 NNP cord-016364-80l5mua2 173 26 ganglioside ganglioside NN cord-016364-80l5mua2 173 27 is be VBZ cord-016364-80l5mua2 173 28 initiated initiate VBN cord-016364-80l5mua2 173 29 by by IN cord-016364-80l5mua2 173 30 coordinated coordinated JJ cord-016364-80l5mua2 173 31 action action NN cord-016364-80l5mua2 173 32 of of IN cord-016364-80l5mua2 173 33 at at RB cord-016364-80l5mua2 173 34 least least RBS cord-016364-80l5mua2 173 35 three three CD cord-016364-80l5mua2 173 36 gene gene NN cord-016364-80l5mua2 173 37 products product NNS cord-016364-80l5mua2 173 38 , , , cord-016364-80l5mua2 173 39 the the DT cord-016364-80l5mua2 173 40 α α NN cord-016364-80l5mua2 173 41 and and CC cord-016364-80l5mua2 173 42 β β NN cord-016364-80l5mua2 173 43 submits submit VBZ cord-016364-80l5mua2 173 44 of of IN cord-016364-80l5mua2 173 45 β β NNP cord-016364-80l5mua2 173 46 - - HYPH cord-016364-80l5mua2 173 47 N N NNP cord-016364-80l5mua2 173 48 - - HYPH cord-016364-80l5mua2 173 49 acetylhexosaminidase acetylhexosaminidase NNP cord-016364-80l5mua2 173 50 and and CC cord-016364-80l5mua2 173 51 the the DT cord-016364-80l5mua2 173 52 G G NNP cord-016364-80l5mua2 173 53 M2 m2 NN cord-016364-80l5mua2 173 54 activator activator NN cord-016364-80l5mua2 173 55 ( ( -LRB- cord-016364-80l5mua2 173 56 GM2A GM2A NNP cord-016364-80l5mua2 173 57 ) ) -RRB- cord-016364-80l5mua2 173 58 protein protein NN cord-016364-80l5mua2 173 59 . . . cord-016364-80l5mua2 174 1 42 42 CD cord-016364-80l5mua2 174 2 , , , cord-016364-80l5mua2 174 3 91 91 CD cord-016364-80l5mua2 174 4 Mutations mutation NNS cord-016364-80l5mua2 174 5 in in IN cord-016364-80l5mua2 174 6 any any DT cord-016364-80l5mua2 174 7 of of IN cord-016364-80l5mua2 174 8 these these DT cord-016364-80l5mua2 174 9 enzymes enzyme NNS cord-016364-80l5mua2 174 10 result result VBP cord-016364-80l5mua2 174 11 in in IN cord-016364-80l5mua2 174 12 an an DT cord-016364-80l5mua2 174 13 accumulation accumulation NN cord-016364-80l5mua2 174 14 of of IN cord-016364-80l5mua2 174 15 gangliosides ganglioside NNS cord-016364-80l5mua2 174 16 G G NNP cord-016364-80l5mua2 174 17 M1 M1 NNP cord-016364-80l5mua2 174 18 and and CC cord-016364-80l5mua2 174 19 G G NNP cord-016364-80l5mua2 174 20 M2 M2 NNP cord-016364-80l5mua2 174 21 in in IN cord-016364-80l5mua2 174 22 the the DT cord-016364-80l5mua2 174 23 lysosomes lysosome NNS cord-016364-80l5mua2 174 24 of of IN cord-016364-80l5mua2 174 25 affected affect VBN cord-016364-80l5mua2 174 26 neurons neuron NNS cord-016364-80l5mua2 174 27 , , , cord-016364-80l5mua2 174 28 resulting result VBG cord-016364-80l5mua2 174 29 in in IN cord-016364-80l5mua2 174 30 progressive progressive JJ cord-016364-80l5mua2 174 31 deterioration deterioration NN cord-016364-80l5mua2 174 32 of of IN cord-016364-80l5mua2 174 33 the the DT cord-016364-80l5mua2 174 34 CNS CNS NNP cord-016364-80l5mua2 174 35 . . . cord-016364-80l5mua2 175 1 Feline feline JJ cord-016364-80l5mua2 175 2 models model NNS cord-016364-80l5mua2 175 3 have have VBP cord-016364-80l5mua2 175 4 been be VBN cord-016364-80l5mua2 175 5 especially especially RB cord-016364-80l5mua2 175 6 important important JJ cord-016364-80l5mua2 175 7 in in IN cord-016364-80l5mua2 175 8 characterizing characterize VBG cord-016364-80l5mua2 175 9 the the DT cord-016364-80l5mua2 175 10 pathobiology pathobiology NN cord-016364-80l5mua2 175 11 and and CC cord-016364-80l5mua2 175 12 molecular molecular JJ cord-016364-80l5mua2 175 13 biology biology NN cord-016364-80l5mua2 175 14 of of IN cord-016364-80l5mua2 175 15 these these DT cord-016364-80l5mua2 175 16 diseases disease NNS cord-016364-80l5mua2 175 17 . . . cord-016364-80l5mua2 176 1 G G NNP cord-016364-80l5mua2 176 2 M2 M2 NNP cord-016364-80l5mua2 176 3 -gangliosidosis -gangliosidosis : cord-016364-80l5mua2 176 4 has have VBZ cord-016364-80l5mua2 176 5 been be VBN cord-016364-80l5mua2 176 6 characterized characterize VBN cord-016364-80l5mua2 176 7 in in IN cord-016364-80l5mua2 176 8 cat cat NN cord-016364-80l5mua2 176 9 models model NNS cord-016364-80l5mua2 176 10 defi defi NNP cord-016364-80l5mua2 176 11 cient cient NNP cord-016364-80l5mua2 176 12 in in IN cord-016364-80l5mua2 176 13 the the DT cord-016364-80l5mua2 176 14 G G NNP cord-016364-80l5mua2 176 15 M2 M2 NNP cord-016364-80l5mua2 176 16 activator activator NN cord-016364-80l5mua2 176 17 protein protein NN cord-016364-80l5mua2 176 18 and and CC cord-016364-80l5mua2 176 19 HexB HexB NNP cord-016364-80l5mua2 176 20 , , , cord-016364-80l5mua2 176 21 40 40 CD cord-016364-80l5mua2 176 22 , , , cord-016364-80l5mua2 176 23 42 42 CD cord-016364-80l5mua2 176 24 , , , cord-016364-80l5mua2 176 25 92 92 CD cord-016364-80l5mua2 176 26 , , , cord-016364-80l5mua2 176 27 93 93 CD cord-016364-80l5mua2 176 28 exhibiting exhibit VBG cord-016364-80l5mua2 176 29 remarkably remarkably RB cord-016364-80l5mua2 176 30 similar similar JJ cord-016364-80l5mua2 176 31 pathology pathology NN cord-016364-80l5mua2 176 32 to to IN cord-016364-80l5mua2 176 33 human human JJ cord-016364-80l5mua2 176 34 Sandhoff Sandhoff NNP cord-016364-80l5mua2 176 35 's 's POS cord-016364-80l5mua2 176 36 disease disease NN cord-016364-80l5mua2 176 37 . . . cord-016364-80l5mua2 177 1 91 91 CD cord-016364-80l5mua2 177 2 Limited limited JJ cord-016364-80l5mua2 177 3 reduction reduction NN cord-016364-80l5mua2 177 4 in in IN cord-016364-80l5mua2 177 5 G G NNP cord-016364-80l5mua2 177 6 M2 M2 NNP cord-016364-80l5mua2 177 7 neuronal neuronal JJ cord-016364-80l5mua2 177 8 storage storage NN cord-016364-80l5mua2 177 9 has have VBZ cord-016364-80l5mua2 177 10 been be VBN cord-016364-80l5mua2 177 11 reported report VBN cord-016364-80l5mua2 177 12 following follow VBG cord-016364-80l5mua2 177 13 bone bone NN cord-016364-80l5mua2 177 14 marrow marrow NN cord-016364-80l5mua2 177 15 therapy therapy NN cord-016364-80l5mua2 177 16 . . . cord-016364-80l5mua2 178 1 86 86 CD cord-016364-80l5mua2 178 2 Feline feline JJ cord-016364-80l5mua2 178 3 models model NNS cord-016364-80l5mua2 178 4 will will MD cord-016364-80l5mua2 178 5 be be VB cord-016364-80l5mua2 178 6 important important JJ cord-016364-80l5mua2 178 7 in in IN cord-016364-80l5mua2 178 8 the the DT cord-016364-80l5mua2 178 9 development development NN cord-016364-80l5mua2 178 10 of of IN cord-016364-80l5mua2 178 11 therapeutic therapeutic JJ cord-016364-80l5mua2 178 12 strategies strategy NNS cord-016364-80l5mua2 178 13 for for IN cord-016364-80l5mua2 178 14 these these DT cord-016364-80l5mua2 178 15 disorders disorder NNS cord-016364-80l5mua2 178 16 . . . cord-016364-80l5mua2 179 1 Mucolipidosis Mucolipidosis NNP cord-016364-80l5mua2 179 2 II II NNP cord-016364-80l5mua2 179 3 ( ( -LRB- cord-016364-80l5mua2 179 4 I i NN cord-016364-80l5mua2 179 5 - - HYPH cord-016364-80l5mua2 179 6 cell cell NN cord-016364-80l5mua2 179 7 disease disease NN cord-016364-80l5mua2 179 8 ) ) -RRB- cord-016364-80l5mua2 179 9 is be VBZ cord-016364-80l5mua2 179 10 caused cause VBN cord-016364-80l5mua2 179 11 by by IN cord-016364-80l5mua2 179 12 deficient deficient JJ cord-016364-80l5mua2 179 13 activity activity NN cord-016364-80l5mua2 179 14 of of IN cord-016364-80l5mua2 179 15 the the DT cord-016364-80l5mua2 179 16 enzyme enzyme NN cord-016364-80l5mua2 179 17 N N NNP cord-016364-80l5mua2 179 18 - - HYPH cord-016364-80l5mua2 179 19 acetylglucosamine-1-phosphotransferase acetylglucosamine-1-phosphotransferase NNP cord-016364-80l5mua2 179 20 , , , cord-016364-80l5mua2 179 21 which which WDT cord-016364-80l5mua2 179 22 leads lead VBZ cord-016364-80l5mua2 179 23 to to IN cord-016364-80l5mua2 179 24 a a DT cord-016364-80l5mua2 179 25 failure failure NN cord-016364-80l5mua2 179 26 to to TO cord-016364-80l5mua2 179 27 internalize internalize VB cord-016364-80l5mua2 179 28 enzymes enzyme NNS cord-016364-80l5mua2 179 29 into into IN cord-016364-80l5mua2 179 30 lysosomes lysosome NNS cord-016364-80l5mua2 179 31 . . . cord-016364-80l5mua2 180 1 The the DT cord-016364-80l5mua2 180 2 cat cat NN cord-016364-80l5mua2 180 3 is be VBZ cord-016364-80l5mua2 180 4 the the DT cord-016364-80l5mua2 180 5 only only RB cord-016364-80l5mua2 180 6 known know VBN cord-016364-80l5mua2 180 7 animal animal NN cord-016364-80l5mua2 180 8 model model NN cord-016364-80l5mua2 180 9 for for IN cord-016364-80l5mua2 180 10 this this DT cord-016364-80l5mua2 180 11 pathology pathology NN cord-016364-80l5mua2 180 12 . . . cord-016364-80l5mua2 181 1 94 94 CD cord-016364-80l5mua2 181 2 Congenital congenital JJ cord-016364-80l5mua2 181 3 diseases disease NNS cord-016364-80l5mua2 181 4 of of IN cord-016364-80l5mua2 181 5 feline feline JJ cord-016364-80l5mua2 181 6 muscle muscle NN cord-016364-80l5mua2 181 7 and and CC cord-016364-80l5mua2 181 8 neuromuscular neuromuscular JJ cord-016364-80l5mua2 181 9 junction junction NN cord-016364-80l5mua2 181 10 have have VBP cord-016364-80l5mua2 181 11 been be VBN cord-016364-80l5mua2 181 12 reviewed review VBN cord-016364-80l5mua2 181 13 by by IN cord-016364-80l5mua2 181 14 Gashen Gashen NNP cord-016364-80l5mua2 181 15 et et NNP cord-016364-80l5mua2 181 16 al al NNP cord-016364-80l5mua2 181 17 . . . cord-016364-80l5mua2 182 1 95 95 CD cord-016364-80l5mua2 183 1 Some some DT cord-016364-80l5mua2 183 2 pathologies pathology NNS cord-016364-80l5mua2 183 3 have have VBP cord-016364-80l5mua2 183 4 been be VBN cord-016364-80l5mua2 183 5 observed observe VBN cord-016364-80l5mua2 183 6 in in IN cord-016364-80l5mua2 183 7 isolated isolated JJ cord-016364-80l5mua2 183 8 breeds breed NNS cord-016364-80l5mua2 183 9 , , , cord-016364-80l5mua2 183 10 including include VBG cord-016364-80l5mua2 183 11 hypokalemic hypokalemic JJ cord-016364-80l5mua2 183 12 myopathy myopathy NN cord-016364-80l5mua2 183 13 of of IN cord-016364-80l5mua2 183 14 Burmese burmese JJ cord-016364-80l5mua2 183 15 cats cat NNS cord-016364-80l5mua2 183 16 , , , cord-016364-80l5mua2 183 17 96 96 CD cord-016364-80l5mua2 183 18 glycogen glycogen NN cord-016364-80l5mua2 183 19 storage storage NN cord-016364-80l5mua2 183 20 disease disease NN cord-016364-80l5mua2 183 21 type type NN cord-016364-80l5mua2 183 22 IV IV NNP cord-016364-80l5mua2 183 23 in in IN cord-016364-80l5mua2 183 24 Norwegian Norwegian NNP cord-016364-80l5mua2 183 25 Forest Forest NNP cord-016364-80l5mua2 183 26 cats cat NNS cord-016364-80l5mua2 183 27 , , , cord-016364-80l5mua2 183 28 44 44 CD cord-016364-80l5mua2 183 29 and and CC cord-016364-80l5mua2 183 30 myopathy myopathy NNS cord-016364-80l5mua2 183 31 observed observe VBN cord-016364-80l5mua2 183 32 in in IN cord-016364-80l5mua2 183 33 the the DT cord-016364-80l5mua2 183 34 Devon Devon NNP cord-016364-80l5mua2 183 35 Rex Rex NNP cord-016364-80l5mua2 183 36 . . . cord-016364-80l5mua2 184 1 97 97 CD cord-016364-80l5mua2 185 1 The the DT cord-016364-80l5mua2 185 2 cat cat NN cord-016364-80l5mua2 185 3 is be VBZ cord-016364-80l5mua2 185 4 the the DT cord-016364-80l5mua2 185 5 only only RB cord-016364-80l5mua2 185 6 reported report VBN cord-016364-80l5mua2 185 7 animal animal NN cord-016364-80l5mua2 185 8 model model NN cord-016364-80l5mua2 185 9 for for IN cord-016364-80l5mua2 185 10 type type NN cord-016364-80l5mua2 185 11 IV IV NNP cord-016364-80l5mua2 185 12 glycogen glycogen NN cord-016364-80l5mua2 185 13 storage storage NN cord-016364-80l5mua2 185 14 disease disease NN cord-016364-80l5mua2 185 15 . . . cord-016364-80l5mua2 186 1 Myotonia Myotonia NNP cord-016364-80l5mua2 186 2 congenital congenital JJ cord-016364-80l5mua2 186 3 , , , cord-016364-80l5mua2 186 4 95,98 95,98 CD cord-016364-80l5mua2 186 5 muscular muscular JJ cord-016364-80l5mua2 186 6 dystrophy dystrophy NN cord-016364-80l5mua2 186 7 ( ( -LRB- cord-016364-80l5mua2 186 8 dystrophin dystrophin NNP cord-016364-80l5mua2 186 9 defi defi NNP cord-016364-80l5mua2 186 10 cient cient NNP cord-016364-80l5mua2 186 11 ) ) -RRB- cord-016364-80l5mua2 186 12 , , , cord-016364-80l5mua2 186 13 52 52 CD cord-016364-80l5mua2 186 14 and and CC cord-016364-80l5mua2 186 15 laminin laminin NN cord-016364-80l5mua2 186 16 α α NNP cord-016364-80l5mua2 186 17 2 2 CD cord-016364-80l5mua2 186 18 defi defi NNP cord-016364-80l5mua2 186 19 ciency ciency NNP cord-016364-80l5mua2 186 20 52 52 CD cord-016364-80l5mua2 186 21 , , , cord-016364-80l5mua2 186 22 99 99 CD cord-016364-80l5mua2 186 23 have have VBP cord-016364-80l5mua2 186 24 also also RB cord-016364-80l5mua2 186 25 been be VBN cord-016364-80l5mua2 186 26 reported report VBN cord-016364-80l5mua2 186 27 in in IN cord-016364-80l5mua2 186 28 the the DT cord-016364-80l5mua2 186 29 cat cat NN cord-016364-80l5mua2 186 30 . . . cord-016364-80l5mua2 187 1 X X NNS cord-016364-80l5mua2 187 2 - - HYPH cord-016364-80l5mua2 187 3 linked link VBN cord-016364-80l5mua2 187 4 muscular muscular JJ cord-016364-80l5mua2 187 5 dystrophy dystrophy NN cord-016364-80l5mua2 187 6 in in IN cord-016364-80l5mua2 187 7 humans human NNS cord-016364-80l5mua2 187 8 is be VBZ cord-016364-80l5mua2 187 9 characterized characterize VBN cord-016364-80l5mua2 187 10 by by IN cord-016364-80l5mua2 187 11 progressive progressive JJ cord-016364-80l5mua2 187 12 degeneration degeneration NN cord-016364-80l5mua2 187 13 of of IN cord-016364-80l5mua2 187 14 skeletal skeletal JJ cord-016364-80l5mua2 187 15 and and CC cord-016364-80l5mua2 187 16 cardiac cardiac JJ cord-016364-80l5mua2 187 17 muscle muscle NN cord-016364-80l5mua2 187 18 . . . cord-016364-80l5mua2 188 1 Mutations mutation NNS cord-016364-80l5mua2 188 2 in in IN cord-016364-80l5mua2 188 3 humans human NNS cord-016364-80l5mua2 188 4 lead lead VBP cord-016364-80l5mua2 188 5 to to IN cord-016364-80l5mua2 188 6 either either CC cord-016364-80l5mua2 188 7 an an DT cord-016364-80l5mua2 188 8 absence absence NN cord-016364-80l5mua2 188 9 of of IN cord-016364-80l5mua2 188 10 or or CC cord-016364-80l5mua2 188 11 abnormality abnormality NN cord-016364-80l5mua2 188 12 in in IN cord-016364-80l5mua2 188 13 the the DT cord-016364-80l5mua2 188 14 protein protein NN cord-016364-80l5mua2 188 15 product product NN cord-016364-80l5mua2 188 16 dystrophin dystrophin NN cord-016364-80l5mua2 188 17 . . . cord-016364-80l5mua2 189 1 100 100 CD cord-016364-80l5mua2 189 2 , , , cord-016364-80l5mua2 189 3 101 101 CD cord-016364-80l5mua2 189 4 A a DT cord-016364-80l5mua2 189 5 deletion deletion NN cord-016364-80l5mua2 189 6 in in IN cord-016364-80l5mua2 189 7 the the DT cord-016364-80l5mua2 189 8 dystrophin dystrophin NN cord-016364-80l5mua2 189 9 muscle muscle NN cord-016364-80l5mua2 189 10 promoter promoter NN cord-016364-80l5mua2 189 11 characterized characterize VBN cord-016364-80l5mua2 189 12 in in IN cord-016364-80l5mua2 189 13 the the DT cord-016364-80l5mua2 189 14 cat cat NN cord-016364-80l5mua2 189 15 eliminates eliminate VBZ cord-016364-80l5mua2 189 16 expression expression NN cord-016364-80l5mua2 189 17 of of IN cord-016364-80l5mua2 189 18 muscle muscle NN cord-016364-80l5mua2 189 19 and and CC cord-016364-80l5mua2 189 20 Purkinje Purkinje NNP cord-016364-80l5mua2 189 21 neuronal neuronal JJ cord-016364-80l5mua2 189 22 dystrophin dystrophin NN cord-016364-80l5mua2 189 23 isoforms isoform NNS cord-016364-80l5mua2 189 24 . . . cord-016364-80l5mua2 190 1 52 52 CD cord-016364-80l5mua2 191 1 Marked mark VBN cord-016364-80l5mua2 191 2 clinical clinical JJ cord-016364-80l5mua2 191 3 heterogeneity heterogeneity NN cord-016364-80l5mua2 191 4 is be VBZ cord-016364-80l5mua2 191 5 observed observe VBN cord-016364-80l5mua2 191 6 in in IN cord-016364-80l5mua2 191 7 these these DT cord-016364-80l5mua2 191 8 models model NNS cord-016364-80l5mua2 191 9 , , , cord-016364-80l5mua2 191 10 from from IN cord-016364-80l5mua2 191 11 severe severe JJ cord-016364-80l5mua2 191 12 disability disability NN cord-016364-80l5mua2 191 13 exhibited exhibit VBN cord-016364-80l5mua2 191 14 in in IN cord-016364-80l5mua2 191 15 human human NN cord-016364-80l5mua2 191 16 and and CC cord-016364-80l5mua2 191 17 dog dog NN cord-016364-80l5mua2 191 18 , , , cord-016364-80l5mua2 191 19 to to IN cord-016364-80l5mua2 191 20 minor minor JJ cord-016364-80l5mua2 191 21 muscle muscle NN cord-016364-80l5mua2 191 22 fi fi NN cord-016364-80l5mua2 191 23 brosis brosis NN cord-016364-80l5mua2 191 24 and and CC cord-016364-80l5mua2 191 25 an an DT cord-016364-80l5mua2 191 26 actual actual JJ cord-016364-80l5mua2 191 27 regenerative regenerative JJ cord-016364-80l5mua2 191 28 process process NN cord-016364-80l5mua2 191 29 leading lead VBG cord-016364-80l5mua2 191 30 to to IN cord-016364-80l5mua2 191 31 muscle muscle NN cord-016364-80l5mua2 191 32 hypertrophy hypertrophy NN cord-016364-80l5mua2 191 33 in in IN cord-016364-80l5mua2 191 34 mouse mouse NN cord-016364-80l5mua2 191 35 and and CC cord-016364-80l5mua2 191 36 cat cat NN cord-016364-80l5mua2 191 37 . . . cord-016364-80l5mua2 192 1 [ [ -LRB- cord-016364-80l5mua2 192 2 102 102 CD cord-016364-80l5mua2 192 3 ] ] -RRB- cord-016364-80l5mua2 192 4 [ [ -LRB- cord-016364-80l5mua2 192 5 103 103 CD cord-016364-80l5mua2 192 6 ] ] -RRB- cord-016364-80l5mua2 193 1 [ [ -LRB- cord-016364-80l5mua2 193 2 104 104 CD cord-016364-80l5mua2 193 3 ] ] -RRB- cord-016364-80l5mua2 194 1 These these DT cord-016364-80l5mua2 194 2 different different JJ cord-016364-80l5mua2 194 3 sequellae sequellae NNS cord-016364-80l5mua2 194 4 could could MD cord-016364-80l5mua2 194 5 be be VB cord-016364-80l5mua2 194 6 important important JJ cord-016364-80l5mua2 194 7 in in IN cord-016364-80l5mua2 194 8 characterizing characterize VBG cord-016364-80l5mua2 194 9 immediate immediate JJ cord-016364-80l5mua2 194 10 and and CC cord-016364-80l5mua2 194 11 secondary secondary JJ cord-016364-80l5mua2 194 12 consequences consequence NNS cord-016364-80l5mua2 194 13 of of IN cord-016364-80l5mua2 194 14 the the DT cord-016364-80l5mua2 194 15 lack lack NN cord-016364-80l5mua2 194 16 of of IN cord-016364-80l5mua2 194 17 dystrophin dystrophin NN cord-016364-80l5mua2 194 18 105 105 CD cord-016364-80l5mua2 194 19 and and CC cord-016364-80l5mua2 194 20 points point VBZ cord-016364-80l5mua2 194 21 out out RP cord-016364-80l5mua2 194 22 the the DT cord-016364-80l5mua2 194 23 importance importance NN cord-016364-80l5mua2 194 24 of of IN cord-016364-80l5mua2 194 25 multiple multiple JJ cord-016364-80l5mua2 194 26 animal animal NN cord-016364-80l5mua2 194 27 models model NNS cord-016364-80l5mua2 194 28 . . . cord-016364-80l5mua2 195 1 Hypertrophic hypertrophic JJ cord-016364-80l5mua2 195 2 cardiomyopathy cardiomyopathy NN cord-016364-80l5mua2 195 3 is be VBZ cord-016364-80l5mua2 195 4 a a DT cord-016364-80l5mua2 195 5 clinically clinically RB cord-016364-80l5mua2 195 6 heterogeneous heterogeneous JJ cord-016364-80l5mua2 195 7 myocardial myocardial JJ cord-016364-80l5mua2 195 8 disease disease NN cord-016364-80l5mua2 195 9 contributing contribute VBG cord-016364-80l5mua2 195 10 to to IN cord-016364-80l5mua2 195 11 one one CD cord-016364-80l5mua2 195 12 of of IN cord-016364-80l5mua2 195 13 the the DT cord-016364-80l5mua2 195 14 most most RBS cord-016364-80l5mua2 195 15 common common JJ cord-016364-80l5mua2 195 16 causes cause NNS cord-016364-80l5mua2 195 17 of of IN cord-016364-80l5mua2 195 18 sudden sudden JJ cord-016364-80l5mua2 195 19 cardiac cardiac JJ cord-016364-80l5mua2 195 20 death death NN cord-016364-80l5mua2 195 21 in in IN cord-016364-80l5mua2 195 22 young young JJ cord-016364-80l5mua2 195 23 adults adult NNS cord-016364-80l5mua2 195 24 . . . cord-016364-80l5mua2 196 1 106 106 CD cord-016364-80l5mua2 197 1 The the DT cord-016364-80l5mua2 197 2 cat cat NN cord-016364-80l5mua2 197 3 represent represent VBP cord-016364-80l5mua2 197 4 the the DT cord-016364-80l5mua2 197 5 first first JJ cord-016364-80l5mua2 197 6 spontaneous spontaneous JJ cord-016364-80l5mua2 197 7 large large JJ cord-016364-80l5mua2 197 8 animal animal NN cord-016364-80l5mua2 197 9 model model NN cord-016364-80l5mua2 197 10 for for IN cord-016364-80l5mua2 197 11 this this DT cord-016364-80l5mua2 197 12 familial familial JJ cord-016364-80l5mua2 197 13 disease disease NN cord-016364-80l5mua2 197 14 47 47 CD cord-016364-80l5mua2 197 15 and and CC cord-016364-80l5mua2 197 16 will will MD cord-016364-80l5mua2 197 17 prove prove VB cord-016364-80l5mua2 197 18 to to TO cord-016364-80l5mua2 197 19 be be VB cord-016364-80l5mua2 197 20 valuable valuable JJ cord-016364-80l5mua2 197 21 for for IN cord-016364-80l5mua2 197 22 examining examine VBG cord-016364-80l5mua2 197 23 pathophysiological pathophysiological JJ cord-016364-80l5mua2 197 24 processes process NNS cord-016364-80l5mua2 197 25 and and CC cord-016364-80l5mua2 197 26 therapeutic therapeutic JJ cord-016364-80l5mua2 197 27 interventions intervention NNS cord-016364-80l5mua2 197 28 . . . cord-016364-80l5mua2 198 1 There there EX cord-016364-80l5mua2 198 2 is be VBZ cord-016364-80l5mua2 198 3 a a DT cord-016364-80l5mua2 198 4 continued continued JJ cord-016364-80l5mua2 198 5 demand demand NN cord-016364-80l5mua2 198 6 for for IN cord-016364-80l5mua2 198 7 alternative alternative JJ cord-016364-80l5mua2 198 8 mammalian mammalian JJ cord-016364-80l5mua2 198 9 models model NNS cord-016364-80l5mua2 198 10 for for IN cord-016364-80l5mua2 198 11 studying study VBG cord-016364-80l5mua2 198 12 human human JJ cord-016364-80l5mua2 198 13 diseases disease NNS cord-016364-80l5mua2 198 14 . . . cord-016364-80l5mua2 199 1 Compared compare VBN cord-016364-80l5mua2 199 2 to to IN cord-016364-80l5mua2 199 3 traditional traditional JJ cord-016364-80l5mua2 199 4 murine murine JJ cord-016364-80l5mua2 199 5 models model NNS cord-016364-80l5mua2 199 6 , , , cord-016364-80l5mua2 199 7 the the DT cord-016364-80l5mua2 199 8 cat cat NN cord-016364-80l5mua2 199 9 's 's POS cord-016364-80l5mua2 199 10 more more RBR cord-016364-80l5mua2 199 11 similar similar JJ cord-016364-80l5mua2 199 12 physiology physiology NN cord-016364-80l5mua2 199 13 , , , cord-016364-80l5mua2 199 14 increased increase VBN cord-016364-80l5mua2 199 15 size size NN cord-016364-80l5mua2 199 16 , , , cord-016364-80l5mua2 199 17 and and CC cord-016364-80l5mua2 199 18 longevity longevity NN cord-016364-80l5mua2 199 19 have have VBP cord-016364-80l5mua2 199 20 made make VBN cord-016364-80l5mua2 199 21 it -PRON- PRP cord-016364-80l5mua2 199 22 ideal ideal JJ cord-016364-80l5mua2 199 23 for for IN cord-016364-80l5mua2 199 24 testing test VBG cord-016364-80l5mua2 199 25 the the DT cord-016364-80l5mua2 199 26 safety safety NN cord-016364-80l5mua2 199 27 and and CC cord-016364-80l5mua2 199 28 efficacy efficacy NN cord-016364-80l5mua2 199 29 of of IN cord-016364-80l5mua2 199 30 some some DT cord-016364-80l5mua2 199 31 therapeutic therapeutic JJ cord-016364-80l5mua2 199 32 modalities modality NNS cord-016364-80l5mua2 199 33 in in IN cord-016364-80l5mua2 199 34 naturally naturally RB cord-016364-80l5mua2 199 35 occurring occur VBG cord-016364-80l5mua2 199 36 feline feline JJ cord-016364-80l5mua2 199 37 disease disease NN cord-016364-80l5mua2 199 38 models model NNS cord-016364-80l5mua2 199 39 . . . cord-016364-80l5mua2 200 1 [ [ -LRB- cord-016364-80l5mua2 200 2 107 107 CD cord-016364-80l5mua2 200 3 ] ] -RRB- cord-016364-80l5mua2 200 4 [ [ -LRB- cord-016364-80l5mua2 200 5 108 108 CD cord-016364-80l5mua2 200 6 ] ] -RRB- cord-016364-80l5mua2 200 7 [ [ -LRB- cord-016364-80l5mua2 200 8 109 109 CD cord-016364-80l5mua2 200 9 ] ] -RRB- cord-016364-80l5mua2 201 1 [ [ -LRB- cord-016364-80l5mua2 201 2 110 110 CD cord-016364-80l5mua2 201 3 ] ] -RRB- cord-016364-80l5mua2 202 1 Additionally additionally RB cord-016364-80l5mua2 202 2 , , , cord-016364-80l5mua2 202 3 cats cat NNS cord-016364-80l5mua2 202 4 have have VBP cord-016364-80l5mua2 202 5 a a DT cord-016364-80l5mua2 202 6 genetically genetically RB cord-016364-80l5mua2 202 7 heterogeneous heterogeneous JJ cord-016364-80l5mua2 202 8 background background NN cord-016364-80l5mua2 202 9 , , , cord-016364-80l5mua2 202 10 similar similar JJ cord-016364-80l5mua2 202 11 to to IN cord-016364-80l5mua2 202 12 humans human NNS cord-016364-80l5mua2 202 13 . . . cord-016364-80l5mua2 203 1 A a DT cord-016364-80l5mua2 203 2 good good JJ cord-016364-80l5mua2 203 3 example example NN cord-016364-80l5mua2 203 4 of of IN cord-016364-80l5mua2 203 5 a a DT cord-016364-80l5mua2 203 6 human human JJ cord-016364-80l5mua2 203 7 disease disease NN cord-016364-80l5mua2 203 8 in in IN cord-016364-80l5mua2 203 9 need need NN cord-016364-80l5mua2 203 10 of of IN cord-016364-80l5mua2 203 11 a a DT cord-016364-80l5mua2 203 12 better well JJR cord-016364-80l5mua2 203 13 mammalian mammalian JJ cord-016364-80l5mua2 203 14 model model NN cord-016364-80l5mua2 203 15 is be VBZ cord-016364-80l5mua2 203 16 cystic cystic JJ cord-016364-80l5mua2 203 17 fibrosis fibrosis NN cord-016364-80l5mua2 203 18 , , . cord-016364-80l5mua2 204 1 as as IN cord-016364-80l5mua2 204 2 mice mouse NNS cord-016364-80l5mua2 204 3 targeted target VBN cord-016364-80l5mua2 204 4 with with IN cord-016364-80l5mua2 204 5 the the DT cord-016364-80l5mua2 204 6 most most RBS cord-016364-80l5mua2 204 7 common common JJ cord-016364-80l5mua2 204 8 human human JJ cord-016364-80l5mua2 204 9 mutation mutation NN cord-016364-80l5mua2 204 10 ( ( -LRB- cord-016364-80l5mua2 204 11 ∆F508 ∆F508 NNP cord-016364-80l5mua2 204 12 ) ) -RRB- cord-016364-80l5mua2 204 13 in in IN cord-016364-80l5mua2 204 14 the the DT cord-016364-80l5mua2 204 15 cystic cystic JJ cord-016364-80l5mua2 204 16 fibrosis fibrosis NN cord-016364-80l5mua2 204 17 transmembrane transmembrane NNP cord-016364-80l5mua2 204 18 receptor receptor NN cord-016364-80l5mua2 204 19 ( ( -LRB- cord-016364-80l5mua2 204 20 CFTR CFTR NNP cord-016364-80l5mua2 204 21 ) ) -RRB- cord-016364-80l5mua2 204 22 fail fail VBP cord-016364-80l5mua2 204 23 to to TO cord-016364-80l5mua2 204 24 spontaneously spontaneously RB cord-016364-80l5mua2 204 25 develop develop VB cord-016364-80l5mua2 204 26 the the DT cord-016364-80l5mua2 204 27 same same JJ cord-016364-80l5mua2 204 28 opportunistic opportunistic JJ cord-016364-80l5mua2 204 29 lung lung NN cord-016364-80l5mua2 204 30 infections infection NNS cord-016364-80l5mua2 204 31 that that WDT cord-016364-80l5mua2 204 32 plague plague VBP cord-016364-80l5mua2 204 33 human human JJ cord-016364-80l5mua2 204 34 patients patient NNS cord-016364-80l5mua2 204 35 with with IN cord-016364-80l5mua2 204 36 cystic cystic NN cord-016364-80l5mua2 204 37 fi fi NN cord-016364-80l5mua2 204 38 brosis brosis NN cord-016364-80l5mua2 204 39 . . . cord-016364-80l5mua2 205 1 111 111 CD cord-016364-80l5mua2 205 2 , , , cord-016364-80l5mua2 205 3 112 112 CD cord-016364-80l5mua2 205 4 One one CD cord-016364-80l5mua2 205 5 group group NN cord-016364-80l5mua2 205 6 has have VBZ cord-016364-80l5mua2 205 7 been be VBN cord-016364-80l5mua2 205 8 working work VBG cord-016364-80l5mua2 205 9 to to TO cord-016364-80l5mua2 205 10 produce produce VB cord-016364-80l5mua2 205 11 a a DT cord-016364-80l5mua2 205 12 ferret ferret JJ cord-016364-80l5mua2 205 13 cystic cystic JJ cord-016364-80l5mua2 205 14 fibrosis fibrosis NN cord-016364-80l5mua2 205 15 model model NN cord-016364-80l5mua2 205 16 through through IN cord-016364-80l5mua2 205 17 gene gene NN cord-016364-80l5mua2 205 18 targeting targeting NN cord-016364-80l5mua2 205 19 of of IN cord-016364-80l5mua2 205 20 somatic somatic JJ cord-016364-80l5mua2 205 21 cells cell NNS cord-016364-80l5mua2 205 22 for for IN cord-016364-80l5mua2 205 23 nuclear nuclear JJ cord-016364-80l5mua2 205 24 transfer transfer NN cord-016364-80l5mua2 205 25 . . . cord-016364-80l5mua2 206 1 113 113 CD cord-016364-80l5mua2 206 2 , , , cord-016364-80l5mua2 206 3 114 114 CD cord-016364-80l5mua2 207 1 While while IN cord-016364-80l5mua2 207 2 reproductive reproductive JJ cord-016364-80l5mua2 207 3 cloning cloning NN cord-016364-80l5mua2 207 4 has have VBZ cord-016364-80l5mua2 207 5 a a DT cord-016364-80l5mua2 207 6 consistently consistently RB cord-016364-80l5mua2 207 7 low low JJ cord-016364-80l5mua2 207 8 success success NN cord-016364-80l5mua2 207 9 rate rate NN cord-016364-80l5mua2 207 10 ( ( -LRB- cord-016364-80l5mua2 207 11 1 1 CD cord-016364-80l5mua2 207 12 - - SYM cord-016364-80l5mua2 207 13 4 4 CD cord-016364-80l5mua2 207 14 % % NN cord-016364-80l5mua2 207 15 ) ) -RRB- cord-016364-80l5mua2 207 16 across across IN cord-016364-80l5mua2 207 17 mammalian mammalian JJ cord-016364-80l5mua2 207 18 species specie NNS cord-016364-80l5mua2 207 19 , , , cord-016364-80l5mua2 207 20 115 115 CD cord-016364-80l5mua2 207 21 targeting target VBG cord-016364-80l5mua2 207 22 genetic genetic JJ cord-016364-80l5mua2 207 23 loci locus NNS cord-016364-80l5mua2 207 24 through through IN cord-016364-80l5mua2 207 25 homologous homologous JJ cord-016364-80l5mua2 207 26 recombination recombination NN cord-016364-80l5mua2 207 27 in in IN cord-016364-80l5mua2 207 28 somatic somatic JJ cord-016364-80l5mua2 207 29 cells cell NNS cord-016364-80l5mua2 207 30 is be VBZ cord-016364-80l5mua2 207 31 currently currently RB cord-016364-80l5mua2 207 32 the the DT cord-016364-80l5mua2 207 33 only only JJ cord-016364-80l5mua2 207 34 viable viable JJ cord-016364-80l5mua2 207 35 method method NN cord-016364-80l5mua2 207 36 for for IN cord-016364-80l5mua2 207 37 producing produce VBG cord-016364-80l5mua2 207 38 knockout knockout NN cord-016364-80l5mua2 207 39 models model NNS cord-016364-80l5mua2 207 40 in in IN cord-016364-80l5mua2 207 41 all all DT cord-016364-80l5mua2 207 42 mammalian mammalian JJ cord-016364-80l5mua2 207 43 species specie NNS cord-016364-80l5mua2 207 44 other other JJ cord-016364-80l5mua2 207 45 than than IN cord-016364-80l5mua2 207 46 the the DT cord-016364-80l5mua2 207 47 mouse mouse NN cord-016364-80l5mua2 207 48 , , , cord-016364-80l5mua2 207 49 for for IN cord-016364-80l5mua2 207 50 which which WDT cord-016364-80l5mua2 207 51 targeted target VBD cord-016364-80l5mua2 207 52 embryonic embryonic JJ cord-016364-80l5mua2 207 53 stem stem NN cord-016364-80l5mua2 207 54 cells cell NNS cord-016364-80l5mua2 207 55 are be VBP cord-016364-80l5mua2 207 56 routinely routinely RB cord-016364-80l5mua2 207 57 used use VBN cord-016364-80l5mua2 207 58 . . . cord-016364-80l5mua2 208 1 Nuclear nuclear JJ cord-016364-80l5mua2 208 2 transfer transfer NN cord-016364-80l5mua2 208 3 of of IN cord-016364-80l5mua2 208 4 targeted target VBN cord-016364-80l5mua2 208 5 fibroblasts fibroblast NNS cord-016364-80l5mua2 208 6 has have VBZ cord-016364-80l5mua2 208 7 been be VBN cord-016364-80l5mua2 208 8 successfully successfully RB cord-016364-80l5mua2 208 9 used use VBN cord-016364-80l5mua2 208 10 to to TO cord-016364-80l5mua2 208 11 produce produce VB cord-016364-80l5mua2 208 12 viable viable JJ cord-016364-80l5mua2 208 13 α-1,3-galactosyltransferase α-1,3-galactosyltransferase JJ cord-016364-80l5mua2 208 14 knockout knockout NN cord-016364-80l5mua2 208 15 pig pig NN cord-016364-80l5mua2 208 16 and and CC cord-016364-80l5mua2 208 17 cow cow NN cord-016364-80l5mua2 208 18 models model NNS cord-016364-80l5mua2 208 19 for for IN cord-016364-80l5mua2 208 20 xenotransplantation xenotransplantation NN cord-016364-80l5mua2 208 21 studies study NNS cord-016364-80l5mua2 208 22 . . . cord-016364-80l5mua2 209 1 116 116 CD cord-016364-80l5mua2 209 2 , , , cord-016364-80l5mua2 209 3 117 117 CD cord-016364-80l5mua2 209 4 With with IN cord-016364-80l5mua2 209 5 the the DT cord-016364-80l5mua2 209 6 successful successful JJ cord-016364-80l5mua2 209 7 reproductive reproductive JJ cord-016364-80l5mua2 209 8 cloning cloning NN cord-016364-80l5mua2 209 9 of of IN cord-016364-80l5mua2 209 10 cats cat NNS cord-016364-80l5mua2 209 11 by by IN cord-016364-80l5mua2 209 12 several several JJ cord-016364-80l5mua2 209 13 groups group NNS cord-016364-80l5mua2 209 14 , , , cord-016364-80l5mua2 209 15 118 118 CD cord-016364-80l5mua2 209 16 - - SYM cord-016364-80l5mua2 209 17 120 120 CD cord-016364-80l5mua2 209 18 the the DT cord-016364-80l5mua2 209 19 development development NN cord-016364-80l5mua2 209 20 of of IN cord-016364-80l5mua2 209 21 gene gene NN cord-016364-80l5mua2 209 22 - - HYPH cord-016364-80l5mua2 209 23 targeted target VBN cord-016364-80l5mua2 209 24 cat cat NN cord-016364-80l5mua2 209 25 models model NNS cord-016364-80l5mua2 209 26 through through IN cord-016364-80l5mua2 209 27 nuclear nuclear JJ cord-016364-80l5mua2 209 28 transfer transfer NN cord-016364-80l5mua2 209 29 is be VBZ cord-016364-80l5mua2 209 30 now now RB cord-016364-80l5mua2 209 31 feasible feasible JJ cord-016364-80l5mua2 209 32 . . . cord-016364-80l5mua2 210 1 121 121 CD cord-016364-80l5mua2 211 1 The the DT cord-016364-80l5mua2 211 2 imminent imminent JJ cord-016364-80l5mua2 211 3 release release NN cord-016364-80l5mua2 211 4 of of IN cord-016364-80l5mua2 211 5 the the DT cord-016364-80l5mua2 211 6 annotated annotate VBN cord-016364-80l5mua2 211 7 feline feline JJ cord-016364-80l5mua2 211 8 genome genome NN cord-016364-80l5mua2 211 9 project project NN cord-016364-80l5mua2 211 10 , , , cord-016364-80l5mua2 211 11 17 17 CD cord-016364-80l5mua2 211 12 integration integration NN cord-016364-80l5mua2 211 13 of of IN cord-016364-80l5mua2 211 14 recombination recombination NN cord-016364-80l5mua2 211 15 and and CC cord-016364-80l5mua2 211 16 radiation radiation NN cord-016364-80l5mua2 211 17 hybrid hybrid JJ cord-016364-80l5mua2 211 18 maps map NNS cord-016364-80l5mua2 211 19 , , , cord-016364-80l5mua2 211 20 [ [ -LRB- cord-016364-80l5mua2 211 21 5 5 CD cord-016364-80l5mua2 211 22 ] ] -RRB- cord-016364-80l5mua2 211 23 [ [ -LRB- cord-016364-80l5mua2 211 24 6 6 CD cord-016364-80l5mua2 211 25 ] ] -RRB- cord-016364-80l5mua2 211 26 [ [ -LRB- cord-016364-80l5mua2 211 27 7 7 CD cord-016364-80l5mua2 211 28 ] ] -RRB- cord-016364-80l5mua2 211 29 [ [ -LRB- cord-016364-80l5mua2 211 30 8 8 CD cord-016364-80l5mua2 211 31 ] ] -RRB- cord-016364-80l5mua2 211 32 [ [ -LRB- cord-016364-80l5mua2 211 33 9 9 CD cord-016364-80l5mua2 211 34 ] ] -RRB- cord-016364-80l5mua2 211 35 [ [ -LRB- cord-016364-80l5mua2 211 36 10 10 CD cord-016364-80l5mua2 211 37 ] ] -RRB- cord-016364-80l5mua2 211 38 122 122 CD cord-016364-80l5mua2 211 39 and and CC cord-016364-80l5mua2 211 40 availability availability NN cord-016364-80l5mua2 211 41 of of IN cord-016364-80l5mua2 211 42 multiple multiple JJ cord-016364-80l5mua2 211 43 PAC PAC NNP cord-016364-80l5mua2 211 44 , , , cord-016364-80l5mua2 211 45 BAC BAC NNP cord-016364-80l5mua2 211 46 , , , cord-016364-80l5mua2 211 47 123 123 CD cord-016364-80l5mua2 211 48 flow flow NN cord-016364-80l5mua2 211 49 - - HYPH cord-016364-80l5mua2 211 50 sorted sort VBN cord-016364-80l5mua2 211 51 autosome autosome NN cord-016364-80l5mua2 211 52 , , , cord-016364-80l5mua2 211 53 and and CC cord-016364-80l5mua2 211 54 Y y NN cord-016364-80l5mua2 211 55 - - HYPH cord-016364-80l5mua2 211 56 chromosome chromosome NN cord-016364-80l5mua2 211 57 libraries library NNS cord-016364-80l5mua2 211 58 124 124 CD cord-016364-80l5mua2 211 59 , , , cord-016364-80l5mua2 211 60 125 125 CD cord-016364-80l5mua2 211 61 ( ( -LRB- cord-016364-80l5mua2 211 62 J. J. NNP cord-016364-80l5mua2 211 63 Pecon Pecon NNP cord-016364-80l5mua2 211 64 - - HYPH cord-016364-80l5mua2 211 65 Slattery Slattery NNP cord-016364-80l5mua2 211 66 et et NNP cord-016364-80l5mua2 211 67 al al NNP cord-016364-80l5mua2 211 68 . . NNP cord-016364-80l5mua2 211 69 , , , cord-016364-80l5mua2 211 70 unpublished unpublished JJ cord-016364-80l5mua2 211 71 observations observation NNS cord-016364-80l5mua2 211 72 ) ) -RRB- cord-016364-80l5mua2 211 73 at at IN cord-016364-80l5mua2 211 74 the the DT cord-016364-80l5mua2 211 75 Laboratory Laboratory NNP cord-016364-80l5mua2 211 76 of of IN cord-016364-80l5mua2 211 77 Genomic Genomic NNP cord-016364-80l5mua2 211 78 Diversity Diversity NNP cord-016364-80l5mua2 211 79 will will MD cord-016364-80l5mua2 211 80 facilitate facilitate VB cord-016364-80l5mua2 211 81 efforts effort NNS cord-016364-80l5mua2 211 82 by by IN cord-016364-80l5mua2 211 83 researchers researcher NNS cord-016364-80l5mua2 211 84 to to TO cord-016364-80l5mua2 211 85 develop develop VB cord-016364-80l5mua2 211 86 new new JJ cord-016364-80l5mua2 211 87 cat cat NN cord-016364-80l5mua2 211 88 models model NNS cord-016364-80l5mua2 211 89 of of IN cord-016364-80l5mua2 211 90 specific specific JJ cord-016364-80l5mua2 211 91 human human JJ cord-016364-80l5mua2 211 92 genetic genetic JJ cord-016364-80l5mua2 211 93 diseases disease NNS cord-016364-80l5mua2 211 94 . . . cord-016364-80l5mua2 212 1 The the DT cord-016364-80l5mua2 212 2 coat coat NN cord-016364-80l5mua2 212 3 color color NN cord-016364-80l5mua2 212 4 loci locus NNS cord-016364-80l5mua2 212 5 influence influence VBP cord-016364-80l5mua2 212 6 the the DT cord-016364-80l5mua2 212 7 development development NN cord-016364-80l5mua2 212 8 , , , cord-016364-80l5mua2 212 9 maturation maturation NN cord-016364-80l5mua2 212 10 , , , cord-016364-80l5mua2 212 11 and and CC cord-016364-80l5mua2 212 12 migration migration NN cord-016364-80l5mua2 212 13 of of IN cord-016364-80l5mua2 212 14 melanocytes melanocyte NNS cord-016364-80l5mua2 212 15 as as RB cord-016364-80l5mua2 212 16 well well RB cord-016364-80l5mua2 212 17 as as IN cord-016364-80l5mua2 212 18 the the DT cord-016364-80l5mua2 212 19 synthesis synthesis NN cord-016364-80l5mua2 212 20 of of IN cord-016364-80l5mua2 212 21 melanin melanin NN cord-016364-80l5mua2 212 22 and and CC cord-016364-80l5mua2 212 23 the the DT cord-016364-80l5mua2 212 24 formation formation NN cord-016364-80l5mua2 212 25 , , , cord-016364-80l5mua2 212 26 transport transport NN cord-016364-80l5mua2 212 27 , , , cord-016364-80l5mua2 212 28 and and CC cord-016364-80l5mua2 212 29 transfer transfer NN cord-016364-80l5mua2 212 30 of of IN cord-016364-80l5mua2 212 31 melanosomes melanosome NNS cord-016364-80l5mua2 212 32 . . . cord-016364-80l5mua2 213 1 Genes gene NNS cord-016364-80l5mua2 213 2 involved involve VBN cord-016364-80l5mua2 213 3 in in IN cord-016364-80l5mua2 213 4 these these DT cord-016364-80l5mua2 213 5 processes process NNS cord-016364-80l5mua2 213 6 often often RB cord-016364-80l5mua2 213 7 have have VBP cord-016364-80l5mua2 213 8 pleiotropic pleiotropic JJ cord-016364-80l5mua2 213 9 effects effect NNS cord-016364-80l5mua2 213 10 , , , cord-016364-80l5mua2 213 11 which which WDT cord-016364-80l5mua2 213 12 impact impact VBP cord-016364-80l5mua2 213 13 other other JJ cord-016364-80l5mua2 213 14 important important JJ cord-016364-80l5mua2 213 15 biochemical biochemical JJ cord-016364-80l5mua2 213 16 pathways pathway NNS cord-016364-80l5mua2 213 17 . . . cord-016364-80l5mua2 214 1 Coat coat NN cord-016364-80l5mua2 214 2 color color NN cord-016364-80l5mua2 214 3 loci locus NNS cord-016364-80l5mua2 214 4 in in IN cord-016364-80l5mua2 214 5 the the DT cord-016364-80l5mua2 214 6 mouse mouse NN cord-016364-80l5mua2 214 7 have have VBP cord-016364-80l5mua2 214 8 been be VBN cord-016364-80l5mua2 214 9 known know VBN cord-016364-80l5mua2 214 10 to to TO cord-016364-80l5mua2 214 11 be be VB cord-016364-80l5mua2 214 12 part part NN cord-016364-80l5mua2 214 13 of of IN cord-016364-80l5mua2 214 14 diverse diverse JJ cord-016364-80l5mua2 214 15 cellular cellular JJ cord-016364-80l5mua2 214 16 , , , cord-016364-80l5mua2 214 17 developmental developmental JJ cord-016364-80l5mua2 214 18 , , , cord-016364-80l5mua2 214 19 and and CC cord-016364-80l5mua2 214 20 physiological physiological JJ cord-016364-80l5mua2 214 21 processes process NNS cord-016364-80l5mua2 214 22 and and CC cord-016364-80l5mua2 214 23 in in IN cord-016364-80l5mua2 214 24 some some DT cord-016364-80l5mua2 214 25 cases case NNS cord-016364-80l5mua2 214 26 to to TO cord-016364-80l5mua2 214 27 be be VB cord-016364-80l5mua2 214 28 implicated implicate VBN cord-016364-80l5mua2 214 29 in in IN cord-016364-80l5mua2 214 30 pathologies pathology NNS cord-016364-80l5mua2 214 31 such such JJ cord-016364-80l5mua2 214 32 as as IN cord-016364-80l5mua2 214 33 anemia anemia NN cord-016364-80l5mua2 214 34 , , , cord-016364-80l5mua2 214 35 sterility sterility NN cord-016364-80l5mua2 214 36 , , , cord-016364-80l5mua2 214 37 and and CC cord-016364-80l5mua2 214 38 neurological neurological JJ cord-016364-80l5mua2 214 39 disorders disorder NNS cord-016364-80l5mua2 214 40 . . . cord-016364-80l5mua2 215 1 [ [ -LRB- cord-016364-80l5mua2 215 2 126 126 CD cord-016364-80l5mua2 215 3 ] ] -RRB- cord-016364-80l5mua2 215 4 [ [ -LRB- cord-016364-80l5mua2 215 5 127 127 CD cord-016364-80l5mua2 215 6 ] ] -RRB- cord-016364-80l5mua2 216 1 [ [ -LRB- cord-016364-80l5mua2 216 2 128 128 CD cord-016364-80l5mua2 216 3 ] ] -RRB- cord-016364-80l5mua2 217 1 The the DT cord-016364-80l5mua2 217 2 cat cat NN cord-016364-80l5mua2 217 3 is be VBZ cord-016364-80l5mua2 217 4 an an DT cord-016364-80l5mua2 217 5 excellent excellent JJ cord-016364-80l5mua2 217 6 model model NN cord-016364-80l5mua2 217 7 system system NN cord-016364-80l5mua2 217 8 with with IN cord-016364-80l5mua2 217 9 which which WDT cord-016364-80l5mua2 217 10 to to TO cord-016364-80l5mua2 217 11 study study VB cord-016364-80l5mua2 217 12 coat coat NN cord-016364-80l5mua2 217 13 color color NN cord-016364-80l5mua2 217 14 phenotypes phenotype NNS cord-016364-80l5mua2 217 15 . . . cord-016364-80l5mua2 218 1 At at RB cord-016364-80l5mua2 218 2 least least JJS cord-016364-80l5mua2 218 3 nine nine CD cord-016364-80l5mua2 218 4 different different JJ cord-016364-80l5mua2 218 5 coat coat NN cord-016364-80l5mua2 218 6 color color NN cord-016364-80l5mua2 218 7 loci locus NNS cord-016364-80l5mua2 218 8 have have VBP cord-016364-80l5mua2 218 9 been be VBN cord-016364-80l5mua2 218 10 identified identify VBN cord-016364-80l5mua2 218 11 in in IN cord-016364-80l5mua2 218 12 the the DT cord-016364-80l5mua2 218 13 cat cat NN cord-016364-80l5mua2 218 14 , , , cord-016364-80l5mua2 218 15 129 129 CD cord-016364-80l5mua2 218 16 and and CC cord-016364-80l5mua2 218 17 several several JJ cord-016364-80l5mua2 218 18 are be VBP cord-016364-80l5mua2 218 19 now now RB cord-016364-80l5mua2 218 20 characterized characterize VBN cord-016364-80l5mua2 218 21 on on IN cord-016364-80l5mua2 218 22 a a DT cord-016364-80l5mua2 218 23 molecular molecular JJ cord-016364-80l5mua2 218 24 genetic genetic JJ cord-016364-80l5mua2 218 25 level level NN cord-016364-80l5mua2 218 26 including include VBG cord-016364-80l5mua2 218 27 , , , cord-016364-80l5mua2 218 28 a a DT cord-016364-80l5mua2 218 29 ( ( -LRB- cord-016364-80l5mua2 218 30 nonagouti nonagouti NNP cord-016364-80l5mua2 218 31 ) ) -RRB- cord-016364-80l5mua2 218 32 responsible responsible JJ cord-016364-80l5mua2 218 33 for for IN cord-016364-80l5mua2 218 34 melanism melanism NN cord-016364-80l5mua2 218 35 , , , cord-016364-80l5mua2 218 36 18 18 CD cord-016364-80l5mua2 218 37 b b LS cord-016364-80l5mua2 218 38 ( ( -LRB- cord-016364-80l5mua2 218 39 Brown Brown NNP cord-016364-80l5mua2 218 40 ) ) -RRB- cord-016364-80l5mua2 218 41 , , , cord-016364-80l5mua2 218 42 which which WDT cord-016364-80l5mua2 218 43 changes change VBZ cord-016364-80l5mua2 218 44 black black JJ cord-016364-80l5mua2 218 45 pigmentation pigmentation NN cord-016364-80l5mua2 218 46 to to IN cord-016364-80l5mua2 218 47 brown brown JJ cord-016364-80l5mua2 218 48 or or CC cord-016364-80l5mua2 218 49 variants variant NNS cord-016364-80l5mua2 218 50 of of IN cord-016364-80l5mua2 218 51 brown brown NNP cord-016364-80l5mua2 218 52 , , , cord-016364-80l5mua2 218 53 32 32 CD cord-016364-80l5mua2 218 54 c c NN cord-016364-80l5mua2 218 55 ( ( -LRB- cord-016364-80l5mua2 218 56 color color NN cord-016364-80l5mua2 218 57 ) ) -RRB- cord-016364-80l5mua2 218 58 , , , cord-016364-80l5mua2 218 59 causing cause VBG cord-016364-80l5mua2 218 60 the the DT cord-016364-80l5mua2 218 61 darker dark JJR cord-016364-80l5mua2 218 62 pigmentation pigmentation NN cord-016364-80l5mua2 218 63 at at IN cord-016364-80l5mua2 218 64 extremities extremity NNS cord-016364-80l5mua2 218 65 ( ( -LRB- cord-016364-80l5mua2 218 66 i.e. i.e. FW cord-016364-80l5mua2 218 67 , , , cord-016364-80l5mua2 218 68 ears ear NNS cord-016364-80l5mua2 218 69 , , , cord-016364-80l5mua2 218 70 tail tail NN cord-016364-80l5mua2 218 71 ) ) -RRB- cord-016364-80l5mua2 218 72 , , , cord-016364-80l5mua2 218 73 observed observe VBN cord-016364-80l5mua2 218 74 in in IN cord-016364-80l5mua2 218 75 Siamese Siamese NNP cord-016364-80l5mua2 218 76 and and CC cord-016364-80l5mua2 218 77 Burmese burmese JJ cord-016364-80l5mua2 218 78 cats cat NNS cord-016364-80l5mua2 218 79 32,37 32,37 CD cord-016364-80l5mua2 218 80 and and CC cord-016364-80l5mua2 218 81 albinism albinism NN cord-016364-80l5mua2 218 82 , , , cord-016364-80l5mua2 218 83 36 36 CD cord-016364-80l5mua2 218 84 and and CC cord-016364-80l5mua2 218 85 d d LS cord-016364-80l5mua2 218 86 ( ( -LRB- cord-016364-80l5mua2 218 87 dilute dilute NN cord-016364-80l5mua2 218 88 ) ) -RRB- cord-016364-80l5mua2 218 89 , , , cord-016364-80l5mua2 218 90 which which WDT cord-016364-80l5mua2 218 91 causes cause VBZ cord-016364-80l5mua2 218 92 dilution dilution NN cord-016364-80l5mua2 218 93 of of IN cord-016364-80l5mua2 218 94 expected expect VBN cord-016364-80l5mua2 218 95 color color NN cord-016364-80l5mua2 218 96 ( ( -LRB- cord-016364-80l5mua2 218 97 i.e. i.e. FW cord-016364-80l5mua2 218 98 , , , cord-016364-80l5mua2 218 99 black black JJ cord-016364-80l5mua2 218 100 pigmentation pigmentation NN cord-016364-80l5mua2 218 101 appears appear VBZ cord-016364-80l5mua2 218 102 gray gray JJ cord-016364-80l5mua2 218 103 ) ) -RRB- cord-016364-80l5mua2 218 104 . . . cord-016364-80l5mua2 219 1 35 35 CD cord-016364-80l5mua2 220 1 The the DT cord-016364-80l5mua2 220 2 cat cat NN cord-016364-80l5mua2 220 3 is be VBZ cord-016364-80l5mua2 220 4 also also RB cord-016364-80l5mua2 220 5 unique unique JJ cord-016364-80l5mua2 220 6 in in IN cord-016364-80l5mua2 220 7 mammalian mammalian JJ cord-016364-80l5mua2 220 8 species specie NNS cord-016364-80l5mua2 220 9 in in IN cord-016364-80l5mua2 220 10 exhibiting exhibit VBG cord-016364-80l5mua2 220 11 a a DT cord-016364-80l5mua2 220 12 variation variation NN cord-016364-80l5mua2 220 13 in in IN cord-016364-80l5mua2 220 14 coat coat NN cord-016364-80l5mua2 220 15 pattern pattern NN cord-016364-80l5mua2 220 16 , , , cord-016364-80l5mua2 220 17 demonstrating demonstrate VBG cord-016364-80l5mua2 220 18 agouti agouti NN cord-016364-80l5mua2 220 19 ( ( -LRB- cord-016364-80l5mua2 220 20 A a NN cord-016364-80l5mua2 220 21 ) ) -RRB- cord-016364-80l5mua2 220 22 ( ( -LRB- cord-016364-80l5mua2 220 23 nonpatterned nonpatterne VBN cord-016364-80l5mua2 220 24 coat coat NN cord-016364-80l5mua2 220 25 ) ) -RRB- cord-016364-80l5mua2 220 26 and and CC cord-016364-80l5mua2 220 27 variants variant NNS cord-016364-80l5mua2 220 28 of of IN cord-016364-80l5mua2 220 29 the the DT cord-016364-80l5mua2 220 30 T T NNP cord-016364-80l5mua2 220 31 ( ( -LRB- cord-016364-80l5mua2 220 32 tabby tabby NNP cord-016364-80l5mua2 220 33 ) ) -RRB- cord-016364-80l5mua2 220 34 locus locus NN cord-016364-80l5mua2 220 35 , , , cord-016364-80l5mua2 220 36 which which WDT cord-016364-80l5mua2 220 37 affect affect VBP cord-016364-80l5mua2 220 38 striping striping NN cord-016364-80l5mua2 220 39 and and CC cord-016364-80l5mua2 220 40 spotting spot VBG cord-016364-80l5mua2 220 41 patterns pattern NNS cord-016364-80l5mua2 220 42 . . . cord-016364-80l5mua2 221 1 The the DT cord-016364-80l5mua2 221 2 cat cat NN cord-016364-80l5mua2 221 3 has have VBZ cord-016364-80l5mua2 221 4 provided provide VBN cord-016364-80l5mua2 221 5 several several JJ cord-016364-80l5mua2 221 6 useful useful JJ cord-016364-80l5mua2 221 7 models model NNS cord-016364-80l5mua2 221 8 for for IN cord-016364-80l5mua2 221 9 infectious infectious JJ cord-016364-80l5mua2 221 10 disease disease NN cord-016364-80l5mua2 221 11 . . . cord-016364-80l5mua2 222 1 These these DT cord-016364-80l5mua2 222 2 include include VBP cord-016364-80l5mua2 222 3 feline feline JJ cord-016364-80l5mua2 222 4 leukemia leukemia NN cord-016364-80l5mua2 222 5 and and CC cord-016364-80l5mua2 222 6 feline feline JJ cord-016364-80l5mua2 222 7 sarcoma sarcoma NN cord-016364-80l5mua2 222 8 virus virus NN cord-016364-80l5mua2 222 9 , , , cord-016364-80l5mua2 222 10 feline feline JJ cord-016364-80l5mua2 222 11 coronavirus coronavirus NN cord-016364-80l5mua2 222 12 , , , cord-016364-80l5mua2 222 13 and and CC cord-016364-80l5mua2 222 14 Type type NN cord-016364-80l5mua2 222 15 C c NN cord-016364-80l5mua2 222 16 retroviruses retrovirus NNS cord-016364-80l5mua2 222 17 that that WDT cord-016364-80l5mua2 222 18 interact interact VBP cord-016364-80l5mua2 222 19 with with IN cord-016364-80l5mua2 222 20 cellular cellular JJ cord-016364-80l5mua2 222 21 oncogenes oncogene NNS cord-016364-80l5mua2 222 22 to to TO cord-016364-80l5mua2 222 23 induce induce VB cord-016364-80l5mua2 222 24 leukemia leukemia NN cord-016364-80l5mua2 222 25 , , , cord-016364-80l5mua2 222 26 lymphoma lymphoma NN cord-016364-80l5mua2 222 27 , , , cord-016364-80l5mua2 222 28 and and CC cord-016364-80l5mua2 222 29 sarcoma sarcoma NN cord-016364-80l5mua2 222 30 . . . cord-016364-80l5mua2 223 1 [ [ -LRB- cord-016364-80l5mua2 223 2 130 130 CD cord-016364-80l5mua2 223 3 ] ] -RRB- cord-016364-80l5mua2 223 4 [ [ -LRB- cord-016364-80l5mua2 223 5 131 131 CD cord-016364-80l5mua2 223 6 ] ] -RRB- cord-016364-80l5mua2 223 7 [ [ -LRB- cord-016364-80l5mua2 223 8 132 132 CD cord-016364-80l5mua2 223 9 ] ] -RRB- cord-016364-80l5mua2 224 1 Historically historically RB cord-016364-80l5mua2 224 2 , , , cord-016364-80l5mua2 224 3 many many JJ cord-016364-80l5mua2 224 4 of of IN cord-016364-80l5mua2 224 5 the the DT cord-016364-80l5mua2 224 6 human human JJ cord-016364-80l5mua2 224 7 oncogenes oncogene NNS cord-016364-80l5mua2 224 8 that that WDT cord-016364-80l5mua2 224 9 defi defi NNP cord-016364-80l5mua2 224 10 ne ne NNP cord-016364-80l5mua2 224 11 signal signal NN cord-016364-80l5mua2 224 12 transduction transduction NN cord-016364-80l5mua2 224 13 pathways pathway NNS cord-016364-80l5mua2 224 14 were be VBD cord-016364-80l5mua2 224 15 originally originally RB cord-016364-80l5mua2 224 16 discovered discover VBN cord-016364-80l5mua2 224 17 in in IN cord-016364-80l5mua2 224 18 the the DT cord-016364-80l5mua2 224 19 context context NN cord-016364-80l5mua2 224 20 of of IN cord-016364-80l5mua2 224 21 feline feline JJ cord-016364-80l5mua2 224 22 leukemia leukemia NN cord-016364-80l5mua2 224 23 virus virus NN cord-016364-80l5mua2 224 24 interaction interaction NN cord-016364-80l5mua2 224 25 in in IN cord-016364-80l5mua2 224 26 cat cat NN cord-016364-80l5mua2 224 27 models model NNS cord-016364-80l5mua2 224 28 . . . cord-016364-80l5mua2 225 1 The the DT cord-016364-80l5mua2 225 2 cat cat NN cord-016364-80l5mua2 225 3 provides provide VBZ cord-016364-80l5mua2 225 4 the the DT cord-016364-80l5mua2 225 5 only only JJ cord-016364-80l5mua2 225 6 naturally naturally RB cord-016364-80l5mua2 225 7 occurring occur VBG cord-016364-80l5mua2 225 8 model model NN cord-016364-80l5mua2 225 9 for for IN cord-016364-80l5mua2 225 10 human human JJ cord-016364-80l5mua2 225 11 AIDS AIDS NNP cord-016364-80l5mua2 225 12 pathogenesis pathogenesis NN cord-016364-80l5mua2 225 13 , , , cord-016364-80l5mua2 225 14 in in IN cord-016364-80l5mua2 225 15 its -PRON- PRP$ cord-016364-80l5mua2 225 16 endemic endemic JJ cord-016364-80l5mua2 225 17 fatal fatal JJ cord-016364-80l5mua2 225 18 transmissible transmissible JJ cord-016364-80l5mua2 225 19 feline feline JJ cord-016364-80l5mua2 225 20 immunodefi immunodefi NNP cord-016364-80l5mua2 225 21 ciency ciency NNP cord-016364-80l5mua2 225 22 virus virus NN cord-016364-80l5mua2 225 23 ( ( -LRB- cord-016364-80l5mua2 225 24 FIV FIV NNP cord-016364-80l5mua2 225 25 ) ) -RRB- cord-016364-80l5mua2 225 26 . . . cord-016364-80l5mua2 226 1 133 133 CD cord-016364-80l5mua2 226 2 , , , cord-016364-80l5mua2 226 3 134 134 CD cord-016364-80l5mua2 226 4 Similar Similar NNP cord-016364-80l5mua2 226 5 to to IN cord-016364-80l5mua2 226 6 its -PRON- PRP$ cord-016364-80l5mua2 226 7 close close JJ cord-016364-80l5mua2 226 8 phylogenetic phylogenetic NN cord-016364-80l5mua2 226 9 relative relative JJ cord-016364-80l5mua2 226 10 HIV HIV NNP cord-016364-80l5mua2 226 11 , , , cord-016364-80l5mua2 226 12 FIV FIV NNP cord-016364-80l5mua2 226 13 induces induce VBZ cord-016364-80l5mua2 226 14 CD4-T CD4-T NNP cord-016364-80l5mua2 226 15 lymphocyte lymphocyte NN cord-016364-80l5mua2 226 16 depletion depletion NN cord-016364-80l5mua2 226 17 in in IN cord-016364-80l5mua2 226 18 affected affect VBN cord-016364-80l5mua2 226 19 cats cat NNS cord-016364-80l5mua2 226 20 , , , cord-016364-80l5mua2 226 21 an an DT cord-016364-80l5mua2 226 22 immune immune JJ cord-016364-80l5mua2 226 23 system system NN cord-016364-80l5mua2 226 24 collapse collapse NN cord-016364-80l5mua2 226 25 , , , cord-016364-80l5mua2 226 26 and and CC cord-016364-80l5mua2 226 27 susceptibility susceptibility NN cord-016364-80l5mua2 226 28 to to IN cord-016364-80l5mua2 226 29 adventitious adventitious JJ cord-016364-80l5mua2 226 30 microbial microbial JJ cord-016364-80l5mua2 226 31 agents agent NNS cord-016364-80l5mua2 226 32 as as IN cord-016364-80l5mua2 226 33 a a DT cord-016364-80l5mua2 226 34 prelude prelude NN cord-016364-80l5mua2 226 35 to to IN cord-016364-80l5mua2 226 36 wasting waste VBG cord-016364-80l5mua2 226 37 disease disease NN cord-016364-80l5mua2 226 38 and and CC cord-016364-80l5mua2 226 39 death death NN cord-016364-80l5mua2 226 40 . . . cord-016364-80l5mua2 227 1 133 133 CD cord-016364-80l5mua2 227 2 , , , cord-016364-80l5mua2 227 3 135 135 CD cord-016364-80l5mua2 227 4 Interestingly interestingly RB cord-016364-80l5mua2 227 5 , , , cord-016364-80l5mua2 227 6 over over IN cord-016364-80l5mua2 227 7 10 10 CD cord-016364-80l5mua2 227 8 wildcat wildcat NN cord-016364-80l5mua2 227 9 species specie NNS cord-016364-80l5mua2 227 10 ( ( -LRB- cord-016364-80l5mua2 227 11 including include VBG cord-016364-80l5mua2 227 12 lions lion NNS cord-016364-80l5mua2 227 13 , , , cord-016364-80l5mua2 227 14 leopards leopard NNS cord-016364-80l5mua2 227 15 , , , cord-016364-80l5mua2 227 16 cheetahs cheetah NNS cord-016364-80l5mua2 227 17 , , , cord-016364-80l5mua2 227 18 ocelots ocelot NNS cord-016364-80l5mua2 227 19 , , , cord-016364-80l5mua2 227 20 pumas puma NNS cord-016364-80l5mua2 227 21 and and CC cord-016364-80l5mua2 227 22 other other JJ cord-016364-80l5mua2 227 23 big big JJ cord-016364-80l5mua2 227 24 cats cat NNS cord-016364-80l5mua2 227 25 ) ) -RRB- cord-016364-80l5mua2 227 26 are be VBP cord-016364-80l5mua2 227 27 endemic endemic JJ cord-016364-80l5mua2 227 28 with with IN cord-016364-80l5mua2 227 29 their -PRON- PRP$ cord-016364-80l5mua2 227 30 own own JJ cord-016364-80l5mua2 227 31 species species NN cord-016364-80l5mua2 227 32 - - HYPH cord-016364-80l5mua2 227 33 specific specific JJ cord-016364-80l5mua2 227 34 strain strain NN cord-016364-80l5mua2 227 35 of of IN cord-016364-80l5mua2 227 36 FIV fiv NN cord-016364-80l5mua2 227 37 [ [ -LRB- cord-016364-80l5mua2 227 38 136 136 CD cord-016364-80l5mua2 227 39 ] ] -RRB- cord-016364-80l5mua2 227 40 [ [ -LRB- cord-016364-80l5mua2 227 41 137 137 CD cord-016364-80l5mua2 227 42 ] ] -RRB- cord-016364-80l5mua2 227 43 [ [ -LRB- cord-016364-80l5mua2 227 44 138 138 CD cord-016364-80l5mua2 227 45 ] ] -RRB- cord-016364-80l5mua2 228 1 [ [ -LRB- cord-016364-80l5mua2 228 2 139 139 CD cord-016364-80l5mua2 228 3 ] ] -RRB- cord-016364-80l5mua2 228 4 [ [ -LRB- cord-016364-80l5mua2 228 5 140 140 CD cord-016364-80l5mua2 228 6 ] ] -RRB- cord-016364-80l5mua2 228 7 [ [ -LRB- cord-016364-80l5mua2 228 8 141 141 CD cord-016364-80l5mua2 228 9 ] ] -RRB- cord-016364-80l5mua2 228 10 ; ; : cord-016364-80l5mua2 228 11 however however RB cord-016364-80l5mua2 228 12 , , , cord-016364-80l5mua2 228 13 unlike unlike IN cord-016364-80l5mua2 228 14 strains strain NNS cord-016364-80l5mua2 228 15 in in IN cord-016364-80l5mua2 228 16 domestic domestic JJ cord-016364-80l5mua2 228 17 cats cat NNS cord-016364-80l5mua2 228 18 , , , cord-016364-80l5mua2 228 19 the the DT cord-016364-80l5mua2 228 20 wildcat wildcat JJ cord-016364-80l5mua2 228 21 FIV FIV NNP cord-016364-80l5mua2 228 22 strains strain NNS cord-016364-80l5mua2 228 23 do do VBP cord-016364-80l5mua2 228 24 not not RB cord-016364-80l5mua2 228 25 appear appear VB cord-016364-80l5mua2 228 26 to to TO cord-016364-80l5mua2 228 27 cause cause VB cord-016364-80l5mua2 228 28 acute acute JJ cord-016364-80l5mua2 228 29 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 228 30 in in IN cord-016364-80l5mua2 228 31 the the DT cord-016364-80l5mua2 228 32 wildcat wildcat NN cord-016364-80l5mua2 228 33 species specie NNS cord-016364-80l5mua2 228 34 , , , cord-016364-80l5mua2 228 35 perhaps perhaps RB cord-016364-80l5mua2 228 36 a a DT cord-016364-80l5mua2 228 37 consequence consequence NN cord-016364-80l5mua2 228 38 of of IN cord-016364-80l5mua2 228 39 historic historic JJ cord-016364-80l5mua2 228 40 natural natural JJ cord-016364-80l5mua2 228 41 selection selection NN cord-016364-80l5mua2 228 42 of of IN cord-016364-80l5mua2 228 43 host host JJ cord-016364-80l5mua2 228 44 genetic genetic JJ cord-016364-80l5mua2 228 45 resistance resistance NN cord-016364-80l5mua2 228 46 to to IN cord-016364-80l5mua2 228 47 the the DT cord-016364-80l5mua2 228 48 fatal fatal JJ cord-016364-80l5mua2 228 49 virus virus NN cord-016364-80l5mua2 228 50 . . . cord-016364-80l5mua2 229 1 139 139 CD cord-016364-80l5mua2 229 2 , , , cord-016364-80l5mua2 229 3 142 142 CD cord-016364-80l5mua2 229 4 Lion Lion NNP cord-016364-80l5mua2 229 5 and and CC cord-016364-80l5mua2 229 6 puma puma NNP cord-016364-80l5mua2 229 7 - - HYPH cord-016364-80l5mua2 229 8 specific specific JJ cord-016364-80l5mua2 229 9 FIV FIV NNP cord-016364-80l5mua2 229 10 strains strain NNS cord-016364-80l5mua2 229 11 have have VBP cord-016364-80l5mua2 229 12 recently recently RB cord-016364-80l5mua2 229 13 been be VBN cord-016364-80l5mua2 229 14 demonstrated demonstrate VBN cord-016364-80l5mua2 229 15 to to TO cord-016364-80l5mua2 229 16 utilize utilize VB cord-016364-80l5mua2 229 17 novel novel JJ cord-016364-80l5mua2 229 18 , , , cord-016364-80l5mua2 229 19 more more RBR cord-016364-80l5mua2 229 20 promiscuous promiscuous JJ cord-016364-80l5mua2 229 21 mechanisms mechanism NNS cord-016364-80l5mua2 229 22 for for IN cord-016364-80l5mua2 229 23 cell cell NN cord-016364-80l5mua2 229 24 entry entry NN cord-016364-80l5mua2 229 25 than than IN cord-016364-80l5mua2 229 26 FIV FIV NNP cord-016364-80l5mua2 229 27 , , , cord-016364-80l5mua2 229 28 suggesting suggest VBG cord-016364-80l5mua2 229 29 a a DT cord-016364-80l5mua2 229 30 divergent divergent JJ cord-016364-80l5mua2 229 31 tropism tropism NN cord-016364-80l5mua2 229 32 and and CC cord-016364-80l5mua2 229 33 biological biological JJ cord-016364-80l5mua2 229 34 properties property NNS cord-016364-80l5mua2 229 35 of of IN cord-016364-80l5mua2 229 36 these these DT cord-016364-80l5mua2 229 37 viruses virus NNS cord-016364-80l5mua2 229 38 . . . cord-016364-80l5mua2 230 1 143 143 CD cord-016364-80l5mua2 231 1 The the DT cord-016364-80l5mua2 231 2 World World NNP cord-016364-80l5mua2 231 3 Health Health NNP cord-016364-80l5mua2 231 4 Organization Organization NNP cord-016364-80l5mua2 231 5 reported report VBD cord-016364-80l5mua2 231 6 a a DT cord-016364-80l5mua2 231 7 new new JJ cord-016364-80l5mua2 231 8 human human JJ cord-016364-80l5mua2 231 9 respiratory respiratory JJ cord-016364-80l5mua2 231 10 illness illness NN cord-016364-80l5mua2 231 11 outbreak outbreak NN cord-016364-80l5mua2 231 12 ( ( -LRB- cord-016364-80l5mua2 231 13 severe severe JJ cord-016364-80l5mua2 231 14 acute acute JJ cord-016364-80l5mua2 231 15 respiratory respiratory JJ cord-016364-80l5mua2 231 16 syndrome syndrome NN cord-016364-80l5mua2 231 17 , , , cord-016364-80l5mua2 231 18 SARS SARS NNP cord-016364-80l5mua2 231 19 ) ) -RRB- cord-016364-80l5mua2 231 20 that that WDT cord-016364-80l5mua2 231 21 emerged emerge VBD cord-016364-80l5mua2 231 22 in in IN cord-016364-80l5mua2 231 23 Guangdong Guangdong NNP cord-016364-80l5mua2 231 24 Province Province NNP cord-016364-80l5mua2 231 25 , , , cord-016364-80l5mua2 231 26 China China NNP cord-016364-80l5mua2 231 27 in in IN cord-016364-80l5mua2 231 28 2003 2003 CD cord-016364-80l5mua2 231 29 . . . cord-016364-80l5mua2 232 1 144 144 CD cord-016364-80l5mua2 232 2 , , , cord-016364-80l5mua2 232 3 145 145 CD cord-016364-80l5mua2 232 4 Sequence sequence NN cord-016364-80l5mua2 232 5 analysis analysis NN cord-016364-80l5mua2 232 6 demonstrated demonstrate VBD cord-016364-80l5mua2 232 7 that that IN cord-016364-80l5mua2 232 8 the the DT cord-016364-80l5mua2 232 9 infectious infectious JJ cord-016364-80l5mua2 232 10 agent agent NN cord-016364-80l5mua2 232 11 was be VBD cord-016364-80l5mua2 232 12 a a DT cord-016364-80l5mua2 232 13 previously previously RB cord-016364-80l5mua2 232 14 unrecognized unrecognized JJ cord-016364-80l5mua2 232 15 coronavirus coronavirus NN cord-016364-80l5mua2 232 16 . . . cord-016364-80l5mua2 233 1 146 146 CD cord-016364-80l5mua2 233 2 , , , cord-016364-80l5mua2 233 3 147 147 CD cord-016364-80l5mua2 234 1 An an DT cord-016364-80l5mua2 234 2 animal animal NN cord-016364-80l5mua2 234 3 model model NN cord-016364-80l5mua2 234 4 demonstrating demonstrate VBG cord-016364-80l5mua2 234 5 clinical clinical JJ cord-016364-80l5mua2 234 6 symptoms symptom NNS cord-016364-80l5mua2 234 7 and and CC cord-016364-80l5mua2 234 8 pathology pathology NN cord-016364-80l5mua2 234 9 of of IN cord-016364-80l5mua2 234 10 SARS SARS NNP cord-016364-80l5mua2 234 11 - - HYPH cord-016364-80l5mua2 234 12 infected infect VBN cord-016364-80l5mua2 234 13 patients patient NNS cord-016364-80l5mua2 234 14 has have VBZ cord-016364-80l5mua2 234 15 not not RB cord-016364-80l5mua2 234 16 been be VBN cord-016364-80l5mua2 234 17 reported report VBN cord-016364-80l5mua2 234 18 . . . cord-016364-80l5mua2 235 1 148 148 CD cord-016364-80l5mua2 235 2 Of of IN cord-016364-80l5mua2 235 3 interest interest NN cord-016364-80l5mua2 236 1 , , , cord-016364-80l5mua2 236 2 the the DT cord-016364-80l5mua2 236 3 recent recent JJ cord-016364-80l5mua2 236 4 report report NN cord-016364-80l5mua2 236 5 of of IN cord-016364-80l5mua2 236 6 a a DT cord-016364-80l5mua2 236 7 highly highly RB cord-016364-80l5mua2 236 8 virulent virulent JJ cord-016364-80l5mua2 236 9 feline feline JJ cord-016364-80l5mua2 236 10 coronavirus coronavirus NN cord-016364-80l5mua2 236 11 epidemic epidemic NN cord-016364-80l5mua2 236 12 in in IN cord-016364-80l5mua2 236 13 captive captive JJ cord-016364-80l5mua2 236 14 African african JJ cord-016364-80l5mua2 236 15 cheetahs cheetah NNS cord-016364-80l5mua2 236 16 , , , cord-016364-80l5mua2 236 17 a a DT cord-016364-80l5mua2 236 18 disease disease NN cord-016364-80l5mua2 236 19 model model NN cord-016364-80l5mua2 236 20 for for IN cord-016364-80l5mua2 236 21 human human JJ cord-016364-80l5mua2 236 22 SARS SARS NNP cord-016364-80l5mua2 236 23 , , , cord-016364-80l5mua2 236 24 illustrates illustrate VBZ cord-016364-80l5mua2 236 25 the the DT cord-016364-80l5mua2 236 26 critical critical JJ cord-016364-80l5mua2 236 27 role role NN cord-016364-80l5mua2 236 28 of of IN cord-016364-80l5mua2 236 29 ancestral ancestral JJ cord-016364-80l5mua2 236 30 population population NN cord-016364-80l5mua2 236 31 genetic genetic JJ cord-016364-80l5mua2 236 32 variation variation NN cord-016364-80l5mua2 236 33 . . . cord-016364-80l5mua2 237 1 132 132 CD cord-016364-80l5mua2 238 1 In in IN cord-016364-80l5mua2 238 2 addition addition NN cord-016364-80l5mua2 238 3 , , , cord-016364-80l5mua2 238 4 cats cat NNS cord-016364-80l5mua2 238 5 injected inject VBN cord-016364-80l5mua2 238 6 with with IN cord-016364-80l5mua2 238 7 the the DT cord-016364-80l5mua2 238 8 SARS SARS NNP cord-016364-80l5mua2 238 9 virus virus NN cord-016364-80l5mua2 238 10 developed develop VBD cord-016364-80l5mua2 238 11 clinical clinical JJ cord-016364-80l5mua2 238 12 symptoms symptom NNS cord-016364-80l5mua2 238 13 , , , cord-016364-80l5mua2 238 14 an an DT cord-016364-80l5mua2 238 15 important important JJ cord-016364-80l5mua2 238 16 insight insight NN cord-016364-80l5mua2 238 17 in in IN cord-016364-80l5mua2 238 18 implicating implicate VBG cord-016364-80l5mua2 238 19 the the DT cord-016364-80l5mua2 238 20 virus virus NN cord-016364-80l5mua2 238 21 in in IN cord-016364-80l5mua2 238 22 the the DT cord-016364-80l5mua2 238 23 SARS SARS NNP cord-016364-80l5mua2 238 24 epidemic epidemic NN cord-016364-80l5mua2 238 25 . . . cord-016364-80l5mua2 239 1 [ [ -LRB- cord-016364-80l5mua2 239 2 149 149 CD cord-016364-80l5mua2 239 3 ] ] -RRB- cord-016364-80l5mua2 239 4 [ [ -LRB- cord-016364-80l5mua2 239 5 150 150 CD cord-016364-80l5mua2 239 6 ] ] -RRB- cord-016364-80l5mua2 239 7 [ [ -LRB- cord-016364-80l5mua2 239 8 151 151 CD cord-016364-80l5mua2 239 9 ] ] -RRB- cord-016364-80l5mua2 240 1 [ [ -LRB- cord-016364-80l5mua2 240 2 152 152 CD cord-016364-80l5mua2 240 3 ] ] -RRB- cord-016364-80l5mua2 241 1 The the DT cord-016364-80l5mua2 241 2 feline feline JJ cord-016364-80l5mua2 241 3 panleukopenia panleukopenia FW cord-016364-80l5mua2 241 4 ( ( -LRB- cord-016364-80l5mua2 241 5 feline feline JJ cord-016364-80l5mua2 241 6 distemper distemper NN cord-016364-80l5mua2 241 7 ) ) -RRB- cord-016364-80l5mua2 241 8 virus virus NN cord-016364-80l5mua2 241 9 has have VBZ cord-016364-80l5mua2 241 10 revealed reveal VBN cord-016364-80l5mua2 241 11 a a DT cord-016364-80l5mua2 241 12 natural natural JJ cord-016364-80l5mua2 241 13 history history NN cord-016364-80l5mua2 241 14 parable parable NN cord-016364-80l5mua2 241 15 in in IN cord-016364-80l5mua2 241 16 its -PRON- PRP$ cord-016364-80l5mua2 241 17 abrupt abrupt JJ cord-016364-80l5mua2 241 18 transformation transformation NN cord-016364-80l5mua2 241 19 of of IN cord-016364-80l5mua2 241 20 the the DT cord-016364-80l5mua2 241 21 cat cat NN cord-016364-80l5mua2 241 22 virus virus NN cord-016364-80l5mua2 241 23 to to IN cord-016364-80l5mua2 241 24 an an DT cord-016364-80l5mua2 241 25 epidemic epidemic NN cord-016364-80l5mua2 241 26 , , , cord-016364-80l5mua2 241 27 fatal fatal JJ cord-016364-80l5mua2 241 28 canine canine JJ cord-016364-80l5mua2 241 29 parvovirus parvovirus NN cord-016364-80l5mua2 241 30 , , , cord-016364-80l5mua2 241 31 that that WDT cord-016364-80l5mua2 241 32 emerged emerge VBD cord-016364-80l5mua2 241 33 in in IN cord-016364-80l5mua2 241 34 the the DT cord-016364-80l5mua2 241 35 world world NN cord-016364-80l5mua2 241 36 's 's POS cord-016364-80l5mua2 241 37 puppy puppy NN cord-016364-80l5mua2 241 38 population population NN cord-016364-80l5mua2 241 39 in in IN cord-016364-80l5mua2 241 40 1978 1978 CD cord-016364-80l5mua2 241 41 . . . cord-016364-80l5mua2 242 1 153 153 CD cord-016364-80l5mua2 243 1 In in IN cord-016364-80l5mua2 243 2 contrast contrast NN cord-016364-80l5mua2 243 3 , , , cord-016364-80l5mua2 243 4 the the DT cord-016364-80l5mua2 243 5 canine canine JJ cord-016364-80l5mua2 243 6 distemper distemper NN cord-016364-80l5mua2 243 7 virus virus NN cord-016364-80l5mua2 243 8 , , , cord-016364-80l5mua2 243 9 which which WDT cord-016364-80l5mua2 243 10 is be VBZ cord-016364-80l5mua2 243 11 normally normally RB cord-016364-80l5mua2 243 12 restricted restrict VBN cord-016364-80l5mua2 243 13 to to IN cord-016364-80l5mua2 243 14 canid canid JJ cord-016364-80l5mua2 243 15 species specie NNS cord-016364-80l5mua2 243 16 , , , cord-016364-80l5mua2 243 17 precipitously precipitously RB cord-016364-80l5mua2 243 18 adapted adapt VBN cord-016364-80l5mua2 243 19 to to IN cord-016364-80l5mua2 243 20 and and CC cord-016364-80l5mua2 243 21 decimated decimate VBN cord-016364-80l5mua2 243 22 East east JJ cord-016364-80l5mua2 243 23 African african JJ cord-016364-80l5mua2 243 24 lions lion NNS cord-016364-80l5mua2 243 25 in in IN cord-016364-80l5mua2 243 26 1994 1994 CD cord-016364-80l5mua2 243 27 , , , cord-016364-80l5mua2 243 28 killing kill VBG cord-016364-80l5mua2 243 29 one one CD cord-016364-80l5mua2 243 30 - - HYPH cord-016364-80l5mua2 243 31 third third NN cord-016364-80l5mua2 243 32 of of IN cord-016364-80l5mua2 243 33 the the DT cord-016364-80l5mua2 243 34 lions lion NNS cord-016364-80l5mua2 243 35 in in IN cord-016364-80l5mua2 243 36 the the DT cord-016364-80l5mua2 243 37 Serengeti Serengeti NNP cord-016364-80l5mua2 243 38 ecosystem ecosystem NN cord-016364-80l5mua2 243 39 within within IN cord-016364-80l5mua2 243 40 a a DT cord-016364-80l5mua2 243 41 9-month 9-month JJ cord-016364-80l5mua2 243 42 outbreak outbreak NN cord-016364-80l5mua2 243 43 . . . cord-016364-80l5mua2 244 1 154 154 CD cord-016364-80l5mua2 245 1 A a DT cord-016364-80l5mua2 245 2 clear clear JJ cord-016364-80l5mua2 245 3 involvement involvement NN cord-016364-80l5mua2 245 4 of of IN cord-016364-80l5mua2 245 5 host host NN cord-016364-80l5mua2 245 6 defense defense NNP cord-016364-80l5mua2 245 7 mecha- mecha- NNP cord-016364-80l5mua2 245 8 nisms nisms NNP cord-016364-80l5mua2 245 9 in in IN cord-016364-80l5mua2 245 10 these these DT cord-016364-80l5mua2 245 11 and and CC cord-016364-80l5mua2 245 12 other other JJ cord-016364-80l5mua2 245 13 infectious infectious JJ cord-016364-80l5mua2 245 14 disease disease NN cord-016364-80l5mua2 245 15 episodes episode NNS cord-016364-80l5mua2 245 16 renders render VBZ cord-016364-80l5mua2 245 17 the the DT cord-016364-80l5mua2 245 18 cats cat NNS cord-016364-80l5mua2 245 19 and and CC cord-016364-80l5mua2 245 20 their -PRON- PRP$ cord-016364-80l5mua2 245 21 pathogens pathogen NNS cord-016364-80l5mua2 245 22 an an DT cord-016364-80l5mua2 245 23 excellent excellent JJ cord-016364-80l5mua2 245 24 candidate candidate NN cord-016364-80l5mua2 245 25 species specie NNS cord-016364-80l5mua2 245 26 for for IN cord-016364-80l5mua2 245 27 characterizing characterize VBG cord-016364-80l5mua2 245 28 the the DT cord-016364-80l5mua2 245 29 interaction interaction NN cord-016364-80l5mua2 245 30 of of IN cord-016364-80l5mua2 245 31 microbial microbial JJ cord-016364-80l5mua2 245 32 adaptation adaptation NN cord-016364-80l5mua2 245 33 and and CC cord-016364-80l5mua2 245 34 host host NN cord-016364-80l5mua2 245 35 disease disease NN cord-016364-80l5mua2 245 36 gene gene NN cord-016364-80l5mua2 245 37 defenses defense NNS cord-016364-80l5mua2 245 38 . . . cord-016364-80l5mua2 246 1 Given give VBN cord-016364-80l5mua2 246 2 the the DT cord-016364-80l5mua2 246 3 critical critical JJ cord-016364-80l5mua2 246 4 importance importance NN cord-016364-80l5mua2 246 5 of of IN cord-016364-80l5mua2 246 6 infectious infectious JJ cord-016364-80l5mua2 246 7 disease disease NN cord-016364-80l5mua2 246 8 in in IN cord-016364-80l5mua2 246 9 scores score NNS cord-016364-80l5mua2 246 10 of of IN cord-016364-80l5mua2 246 11 chronic chronic JJ cord-016364-80l5mua2 246 12 and and CC cord-016364-80l5mua2 246 13 acute acute JJ cord-016364-80l5mua2 246 14 human human JJ cord-016364-80l5mua2 246 15 disease disease NN cord-016364-80l5mua2 246 16 , , , cord-016364-80l5mua2 246 17 there there EX cord-016364-80l5mua2 246 18 are be VBP cord-016364-80l5mua2 246 19 powerful powerful JJ cord-016364-80l5mua2 246 20 research research NN cord-016364-80l5mua2 246 21 opportunities opportunity NNS cord-016364-80l5mua2 246 22 in in IN cord-016364-80l5mua2 246 23 the the DT cord-016364-80l5mua2 246 24 cat cat NN cord-016364-80l5mua2 246 25 family family NN cord-016364-80l5mua2 246 26 . . . cord-016364-80l5mua2 247 1 142 142 CD cord-016364-80l5mua2 247 2 , , , cord-016364-80l5mua2 247 3 155 155 CD cord-016364-80l5mua2 247 4 Finally finally RB cord-016364-80l5mua2 247 5 , , , cord-016364-80l5mua2 247 6 recent recent JJ cord-016364-80l5mua2 247 7 concern concern NN cord-016364-80l5mua2 247 8 over over IN cord-016364-80l5mua2 247 9 the the DT cord-016364-80l5mua2 247 10 emergence emergence NN cord-016364-80l5mua2 247 11 of of IN cord-016364-80l5mua2 247 12 avian avian JJ cord-016364-80l5mua2 247 13 flu flu NN cord-016364-80l5mua2 247 14 H5N1 H5N1 NNP cord-016364-80l5mua2 247 15 has have VBZ cord-016364-80l5mua2 247 16 shown show VBN cord-016364-80l5mua2 247 17 a a DT cord-016364-80l5mua2 247 18 strong strong JJ cord-016364-80l5mua2 247 19 susceptibility susceptibility NN cord-016364-80l5mua2 247 20 of of IN cord-016364-80l5mua2 247 21 cats cat NNS cord-016364-80l5mua2 247 22 , , , cord-016364-80l5mua2 247 23 both both CC cord-016364-80l5mua2 247 24 domestic domestic JJ cord-016364-80l5mua2 247 25 and and CC cord-016364-80l5mua2 247 26 large large JJ cord-016364-80l5mua2 247 27 cats cat NNS cord-016364-80l5mua2 247 28 , , , cord-016364-80l5mua2 247 29 again again RB cord-016364-80l5mua2 247 30 raising raise VBG cord-016364-80l5mua2 247 31 possibilities possibility NNS cord-016364-80l5mua2 247 32 for for IN cord-016364-80l5mua2 247 33 pathogenesis pathogenesis NN cord-016364-80l5mua2 247 34 and and CC cord-016364-80l5mua2 247 35 therapy therapy NN cord-016364-80l5mua2 247 36 development development NN cord-016364-80l5mua2 247 37 . . . cord-016364-80l5mua2 248 1 156 156 CD cord-016364-80l5mua2 248 2 , , , cord-016364-80l5mua2 248 3 157 157 CD cord-016364-80l5mua2 248 4 With with IN cord-016364-80l5mua2 248 5 the the DT cord-016364-80l5mua2 248 6 development development NN cord-016364-80l5mua2 248 7 of of IN cord-016364-80l5mua2 248 8 genomic genomic JJ cord-016364-80l5mua2 248 9 resources resource NNS cord-016364-80l5mua2 248 10 in in IN cord-016364-80l5mua2 248 11 the the DT cord-016364-80l5mua2 248 12 cat cat NN cord-016364-80l5mua2 248 13 ( ( -LRB- cord-016364-80l5mua2 248 14 Table table NN cord-016364-80l5mua2 248 15 _SP cord-016364-80l5mua2 248 16 25 25 CD cord-016364-80l5mua2 248 17 -2 -2 CD cord-016364-80l5mua2 248 18 ) ) -RRB- cord-016364-80l5mua2 248 19 and and CC cord-016364-80l5mua2 248 20 the the DT cord-016364-80l5mua2 248 21 application application NN cord-016364-80l5mua2 248 22 of of IN cord-016364-80l5mua2 248 23 complementary complementary JJ cord-016364-80l5mua2 248 24 comparative comparative JJ cord-016364-80l5mua2 248 25 tools tool NNS cord-016364-80l5mua2 248 26 developed develop VBN cord-016364-80l5mua2 248 27 in in IN cord-016364-80l5mua2 248 28 other other JJ cord-016364-80l5mua2 248 29 species specie NNS cord-016364-80l5mua2 248 30 , , , cord-016364-80l5mua2 248 31 the the DT cord-016364-80l5mua2 248 32 domestic domestic JJ cord-016364-80l5mua2 248 33 cat cat NN cord-016364-80l5mua2 248 34 is be VBZ cord-016364-80l5mua2 248 35 emerging emerge VBG cord-016364-80l5mua2 248 36 as as IN cord-016364-80l5mua2 248 37 a a DT cord-016364-80l5mua2 248 38 promising promising JJ cord-016364-80l5mua2 248 39 resource resource NN cord-016364-80l5mua2 248 40 of of IN cord-016364-80l5mua2 248 41 phenotypically phenotypically RB cord-016364-80l5mua2 248 42 defined define VBN cord-016364-80l5mua2 248 43 genetic genetic JJ cord-016364-80l5mua2 248 44 variation variation NN cord-016364-80l5mua2 248 45 of of IN cord-016364-80l5mua2 248 46 biomedical biomedical JJ cord-016364-80l5mua2 248 47 significance significance NN cord-016364-80l5mua2 248 48 . . . cord-016364-80l5mua2 249 1 Exploration exploration NN cord-016364-80l5mua2 249 2 of of IN cord-016364-80l5mua2 249 3 similar similar JJ cord-016364-80l5mua2 249 4 resources resource NNS cord-016364-80l5mua2 249 5 in in IN cord-016364-80l5mua2 249 6 other other JJ cord-016364-80l5mua2 249 7 species specie NNS cord-016364-80l5mua2 249 8 , , , cord-016364-80l5mua2 249 9 particularly particularly RB cord-016364-80l5mua2 249 10 the the DT cord-016364-80l5mua2 249 11 dog dog NN cord-016364-80l5mua2 249 12 and and CC cord-016364-80l5mua2 249 13 mouse mouse NN cord-016364-80l5mua2 249 14 , , , cord-016364-80l5mua2 249 15 has have VBZ cord-016364-80l5mua2 249 16 provided provide VBN cord-016364-80l5mua2 249 17 important important JJ cord-016364-80l5mua2 249 18 insight insight NN cord-016364-80l5mua2 249 19 into into IN cord-016364-80l5mua2 249 20 otherwise otherwise RB cord-016364-80l5mua2 249 21 unexplained unexplained JJ cord-016364-80l5mua2 249 22 biomedical biomedical JJ cord-016364-80l5mua2 249 23 disorders disorder NNS cord-016364-80l5mua2 249 24 . . . cord-016364-80l5mua2 250 1 Early early RB cord-016364-80l5mua2 250 2 taming taming NN cord-016364-80l5mua2 250 3 of of IN cord-016364-80l5mua2 250 4 the the DT cord-016364-80l5mua2 250 5 cat cat NN cord-016364-80l5mua2 250 6 in in IN cord-016364-80l5mua2 250 7 Cyprus Cyprus NNP cord-016364-80l5mua2 251 1 The the DT cord-016364-80l5mua2 251 2 Feline Feline NNP cord-016364-80l5mua2 251 3 Genome Genome NNP cord-016364-80l5mua2 251 4 Project Project NNP cord-016364-80l5mua2 251 5 Integration Integration NNP cord-016364-80l5mua2 251 6 of of IN cord-016364-80l5mua2 251 7 the the DT cord-016364-80l5mua2 251 8 feline feline JJ cord-016364-80l5mua2 251 9 radiation radiation NN cord-016364-80l5mua2 251 10 hybrid hybrid NN cord-016364-80l5mua2 251 11 and and CC cord-016364-80l5mua2 251 12 linkage linkage NN cord-016364-80l5mua2 251 13 maps map NNS cord-016364-80l5mua2 252 1 Radiation radiation NN cord-016364-80l5mua2 252 2 hybrid hybrid NN cord-016364-80l5mua2 252 3 mapping mapping NN cord-016364-80l5mua2 252 4 of of IN cord-016364-80l5mua2 252 5 304 304 CD cord-016364-80l5mua2 252 6 novel novel JJ cord-016364-80l5mua2 252 7 microsatellites microsatellite NNS cord-016364-80l5mua2 252 8 in in IN cord-016364-80l5mua2 252 9 the the DT cord-016364-80l5mua2 252 10 domestic domestic JJ cord-016364-80l5mua2 252 11 cat cat NN cord-016364-80l5mua2 252 12 genome genome NN cord-016364-80l5mua2 253 1 A a DT cord-016364-80l5mua2 253 2 genetic genetic JJ cord-016364-80l5mua2 253 3 linkage linkage NN cord-016364-80l5mua2 253 4 map map NN cord-016364-80l5mua2 253 5 of of IN cord-016364-80l5mua2 253 6 microsatellites microsatellite NNS cord-016364-80l5mua2 253 7 in in IN cord-016364-80l5mua2 253 8 the the DT cord-016364-80l5mua2 253 9 domestic domestic JJ cord-016364-80l5mua2 253 10 cat cat NN cord-016364-80l5mua2 253 11 ( ( -LRB- cord-016364-80l5mua2 253 12 Felis Felis NNP cord-016364-80l5mua2 253 13 catus catus NN cord-016364-80l5mua2 253 14 ) ) -RRB- cord-016364-80l5mua2 254 1 A a DT cord-016364-80l5mua2 254 2 1.5 1.5 CD cord-016364-80l5mua2 254 3 megabase megabase NN cord-016364-80l5mua2 254 4 resolution resolution NN cord-016364-80l5mua2 254 5 radiation radiation NN cord-016364-80l5mua2 254 6 hybrid hybrid NN cord-016364-80l5mua2 254 7 map map NN cord-016364-80l5mua2 254 8 of of IN cord-016364-80l5mua2 254 9 the the DT cord-016364-80l5mua2 254 10 cat cat NN cord-016364-80l5mua2 254 11 genome genome NN cord-016364-80l5mua2 254 12 and and CC cord-016364-80l5mua2 254 13 comparative comparative JJ cord-016364-80l5mua2 254 14 analysis analysis NN cord-016364-80l5mua2 254 15 with with IN cord-016364-80l5mua2 254 16 the the DT cord-016364-80l5mua2 254 17 canine canine JJ cord-016364-80l5mua2 254 18 and and CC cord-016364-80l5mua2 254 19 human human JJ cord-016364-80l5mua2 254 20 genomes genome NNS cord-016364-80l5mua2 254 21 Second second JJ cord-016364-80l5mua2 254 22 - - HYPH cord-016364-80l5mua2 254 23 generation generation NN cord-016364-80l5mua2 254 24 integrated integrate VBN cord-016364-80l5mua2 254 25 genetic genetic JJ cord-016364-80l5mua2 254 26 linkage linkage NN cord-016364-80l5mua2 254 27 / / SYM cord-016364-80l5mua2 254 28 radiation radiation NN cord-016364-80l5mua2 254 29 hybrid hybrid NN cord-016364-80l5mua2 254 30 maps map NNS cord-016364-80l5mua2 254 31 of of IN cord-016364-80l5mua2 254 32 the the DT cord-016364-80l5mua2 254 33 domestic domestic JJ cord-016364-80l5mua2 254 34 cat cat NN cord-016364-80l5mua2 254 35 ( ( -LRB- cord-016364-80l5mua2 254 36 Felis Felis NNP cord-016364-80l5mua2 254 37 catus catus NN cord-016364-80l5mua2 254 38 ) ) -RRB- cord-016364-80l5mua2 255 1 A a DT cord-016364-80l5mua2 255 2 third third JJ cord-016364-80l5mua2 255 3 - - HYPH cord-016364-80l5mua2 255 4 generation generation NN cord-016364-80l5mua2 255 5 RH RH NNP cord-016364-80l5mua2 255 6 map map NN cord-016364-80l5mua2 255 7 of of IN cord-016364-80l5mua2 255 8 the the DT cord-016364-80l5mua2 255 9 domestic domestic JJ cord-016364-80l5mua2 255 10 cat cat NN cord-016364-80l5mua2 255 11 Extensive extensive JJ cord-016364-80l5mua2 255 12 conservation conservation NN cord-016364-80l5mua2 255 13 of of IN cord-016364-80l5mua2 255 14 sex sex NN cord-016364-80l5mua2 255 15 chromosome chromosome NN cord-016364-80l5mua2 255 16 organization organization NN cord-016364-80l5mua2 255 17 between between IN cord-016364-80l5mua2 255 18 cat cat NN cord-016364-80l5mua2 255 19 and and CC cord-016364-80l5mua2 255 20 human human NN cord-016364-80l5mua2 255 21 revealed reveal VBN cord-016364-80l5mua2 255 22 by by IN cord-016364-80l5mua2 255 23 parallel parallel JJ cord-016364-80l5mua2 255 24 radiation radiation NN cord-016364-80l5mua2 255 25 hybrid hybrid NN cord-016364-80l5mua2 255 26 mapping mapping NN cord-016364-80l5mua2 255 27 Genetic genetic JJ cord-016364-80l5mua2 255 28 mapping mapping NN cord-016364-80l5mua2 255 29 in in IN cord-016364-80l5mua2 255 30 mammals mammal NNS cord-016364-80l5mua2 255 31 : : : cord-016364-80l5mua2 256 1 Chromosome chromosome NN cord-016364-80l5mua2 256 2 map map NN cord-016364-80l5mua2 256 3 of of IN cord-016364-80l5mua2 256 4 domestic domestic JJ cord-016364-80l5mua2 256 5 cat cat NN cord-016364-80l5mua2 257 1 A a DT cord-016364-80l5mua2 257 2 radiation radiation NN cord-016364-80l5mua2 257 3 hybrid hybrid NN cord-016364-80l5mua2 257 4 map map NN cord-016364-80l5mua2 257 5 of of IN cord-016364-80l5mua2 257 6 the the DT cord-016364-80l5mua2 257 7 cat cat NN cord-016364-80l5mua2 257 8 genome genome NN cord-016364-80l5mua2 257 9 : : : cord-016364-80l5mua2 258 1 Implications implication NNS cord-016364-80l5mua2 258 2 for for IN cord-016364-80l5mua2 258 3 comparative comparative JJ cord-016364-80l5mua2 258 4 mapping mapping NN cord-016364-80l5mua2 258 5 Novel Novel NNP cord-016364-80l5mua2 258 6 gene gene NN cord-016364-80l5mua2 258 7 acquisition acquisition NN cord-016364-80l5mua2 258 8 on on IN cord-016364-80l5mua2 258 9 carnivore carnivore NNP cord-016364-80l5mua2 258 10 Y Y NNP cord-016364-80l5mua2 258 11 chromosomes chromosome VBZ cord-016364-80l5mua2 258 12 Comparative comparative JJ cord-016364-80l5mua2 258 13 genomics genomic NNS cord-016364-80l5mua2 258 14 : : : cord-016364-80l5mua2 259 1 Lessons lesson NNS cord-016364-80l5mua2 259 2 from from IN cord-016364-80l5mua2 259 3 cats cat NNS cord-016364-80l5mua2 259 4 Comparative comparative JJ cord-016364-80l5mua2 259 5 gene gene NN cord-016364-80l5mua2 259 6 mapping mapping NN cord-016364-80l5mua2 259 7 in in IN cord-016364-80l5mua2 259 8 the the DT cord-016364-80l5mua2 259 9 domestic domestic JJ cord-016364-80l5mua2 259 10 cat cat NN cord-016364-80l5mua2 259 11 ( ( -LRB- cord-016364-80l5mua2 259 12 Felis Felis NNP cord-016364-80l5mua2 259 13 catus catus NN cord-016364-80l5mua2 259 14 ) ) -RRB- cord-016364-80l5mua2 260 1 The the DT cord-016364-80l5mua2 260 2 domestic domestic JJ cord-016364-80l5mua2 260 3 cat cat NN cord-016364-80l5mua2 260 4 genome genome NN cord-016364-80l5mua2 260 5 sequence sequence NN cord-016364-80l5mua2 260 6 annotation annotation NN cord-016364-80l5mua2 260 7 and and CC cord-016364-80l5mua2 260 8 comparative comparative JJ cord-016364-80l5mua2 260 9 inferences inference NNS cord-016364-80l5mua2 260 10 Genome Genome NNP cord-016364-80l5mua2 260 11 sequence sequence NN cord-016364-80l5mua2 260 12 , , , cord-016364-80l5mua2 260 13 comparative comparative JJ cord-016364-80l5mua2 260 14 analysis analysis NN cord-016364-80l5mua2 260 15 and and CC cord-016364-80l5mua2 260 16 haplotype haplotype NN cord-016364-80l5mua2 260 17 structure structure NN cord-016364-80l5mua2 260 18 of of IN cord-016364-80l5mua2 260 19 the the DT cord-016364-80l5mua2 260 20 domestic domestic JJ cord-016364-80l5mua2 260 21 dog dog NN cord-016364-80l5mua2 260 22 Identifi Identifi NNP cord-016364-80l5mua2 260 23 cation cation NN cord-016364-80l5mua2 260 24 and and CC cord-016364-80l5mua2 260 25 characterization characterization NN cord-016364-80l5mua2 260 26 of of IN cord-016364-80l5mua2 260 27 multi multi JJ cord-016364-80l5mua2 260 28 - - JJ cord-016364-80l5mua2 260 29 species species JJ cord-016364-80l5mua2 260 30 conserved conserve VBN cord-016364-80l5mua2 260 31 sequences sequence NNS cord-016364-80l5mua2 261 1 An an DT cord-016364-80l5mua2 261 2 initial initial JJ cord-016364-80l5mua2 261 3 strategy strategy NN cord-016364-80l5mua2 261 4 for for IN cord-016364-80l5mua2 261 5 the the DT cord-016364-80l5mua2 261 6 systematic systematic JJ cord-016364-80l5mua2 261 7 identification identification NN cord-016364-80l5mua2 261 8 of of IN cord-016364-80l5mua2 261 9 functional functional JJ cord-016364-80l5mua2 261 10 elements element NNS cord-016364-80l5mua2 261 11 in in IN cord-016364-80l5mua2 261 12 the the DT cord-016364-80l5mua2 261 13 human human JJ cord-016364-80l5mua2 261 14 genome genome NN cord-016364-80l5mua2 261 15 by by IN cord-016364-80l5mua2 261 16 low low JJ cord-016364-80l5mua2 261 17 - - HYPH cord-016364-80l5mua2 261 18 redundancy redundancy NN cord-016364-80l5mua2 261 19 comparative comparative JJ cord-016364-80l5mua2 261 20 sequencing sequencing NN cord-016364-80l5mua2 261 21 Hereditary hereditary JJ cord-016364-80l5mua2 261 22 progressive progressive JJ cord-016364-80l5mua2 261 23 retinal retinal JJ cord-016364-80l5mua2 261 24 atrophy atrophy NN cord-016364-80l5mua2 261 25 in in IN cord-016364-80l5mua2 261 26 the the DT cord-016364-80l5mua2 261 27 Abyssinian abyssinian JJ cord-016364-80l5mua2 261 28 cat cat NN cord-016364-80l5mua2 261 29 Genetic genetic JJ cord-016364-80l5mua2 261 30 structure structure NN cord-016364-80l5mua2 261 31 of of IN cord-016364-80l5mua2 261 32 the the DT cord-016364-80l5mua2 261 33 purebred purebred JJ cord-016364-80l5mua2 261 34 domestic domestic JJ cord-016364-80l5mua2 261 35 dog dog NNP cord-016364-80l5mua2 261 36 Dog Dog NNP cord-016364-80l5mua2 261 37 star star NN cord-016364-80l5mua2 261 38 rising rise VBG cord-016364-80l5mua2 261 39 : : : cord-016364-80l5mua2 261 40 The the DT cord-016364-80l5mua2 261 41 canine canine JJ cord-016364-80l5mua2 261 42 genetic genetic JJ cord-016364-80l5mua2 261 43 system system NN cord-016364-80l5mua2 261 44 Linkage linkage NN cord-016364-80l5mua2 261 45 disequilibrium disequilibrium NN cord-016364-80l5mua2 261 46 maps map NNS cord-016364-80l5mua2 261 47 and and CC cord-016364-80l5mua2 261 48 association association NN cord-016364-80l5mua2 261 49 mapping mapping NN cord-016364-80l5mua2 262 1 Extensive extensive JJ cord-016364-80l5mua2 262 2 and and CC cord-016364-80l5mua2 262 3 breedspecifi breedspecifi NNP cord-016364-80l5mua2 262 4 c c NNP cord-016364-80l5mua2 262 5 linkage linkage NN cord-016364-80l5mua2 262 6 disequilibrium disequilibrium NN cord-016364-80l5mua2 262 7 in in IN cord-016364-80l5mua2 262 8 Canis Canis NNP cord-016364-80l5mua2 262 9 familiaris familiaris NN cord-016364-80l5mua2 263 1 The the DT cord-016364-80l5mua2 263 2 canine canine JJ cord-016364-80l5mua2 263 3 genome genome NN cord-016364-80l5mua2 263 4 Understanding understand VBG cord-016364-80l5mua2 263 5 the the DT cord-016364-80l5mua2 263 6 genetics genetic NNS cord-016364-80l5mua2 263 7 of of IN cord-016364-80l5mua2 263 8 autoimmune autoimmune JJ cord-016364-80l5mua2 263 9 disease disease NN cord-016364-80l5mua2 263 10 : : : cord-016364-80l5mua2 264 1 Two two CD cord-016364-80l5mua2 264 2 loci locus NNS cord-016364-80l5mua2 264 3 that that WDT cord-016364-80l5mua2 264 4 regulate regulate VBP cord-016364-80l5mua2 264 5 late late JJ cord-016364-80l5mua2 264 6 onset onset NN cord-016364-80l5mua2 264 7 Addison Addison NNP cord-016364-80l5mua2 264 8 's 's POS cord-016364-80l5mua2 264 9 disease disease NN cord-016364-80l5mua2 264 10 in in IN cord-016364-80l5mua2 264 11 Portuguese portuguese JJ cord-016364-80l5mua2 264 12 Water Water NNP cord-016364-80l5mua2 264 13 Dogs Dogs NNP cord-016364-80l5mua2 264 14 Canine Canine NNP cord-016364-80l5mua2 264 15 RPGRIP1 RPGRIP1 : cord-016364-80l5mua2 264 16 mutation mutation NN cord-016364-80l5mua2 264 17 establishes establish VBZ cord-016364-80l5mua2 264 18 cone cone NN cord-016364-80l5mua2 264 19 - - HYPH cord-016364-80l5mua2 264 20 rod rod NN cord-016364-80l5mua2 264 21 dystrophy dystrophy NN cord-016364-80l5mua2 264 22 in in IN cord-016364-80l5mua2 264 23 miniature miniature JJ cord-016364-80l5mua2 264 24 longhaired longhaired JJ cord-016364-80l5mua2 264 25 dachshunds dachshund NNS cord-016364-80l5mua2 264 26 as as IN cord-016364-80l5mua2 264 27 a a DT cord-016364-80l5mua2 264 28 homologue homologue NN cord-016364-80l5mua2 264 29 of of IN cord-016364-80l5mua2 264 30 human human JJ cord-016364-80l5mua2 264 31 Leber Leber NNP cord-016364-80l5mua2 264 32 congenital congenital JJ cord-016364-80l5mua2 264 33 amaurosis amaurosis NN cord-016364-80l5mua2 264 34 Cat cat NN cord-016364-80l5mua2 264 35 domestication domestication NN cord-016364-80l5mua2 264 36 age age NN cord-016364-80l5mua2 265 1 An an DT cord-016364-80l5mua2 265 2 STR STR NNP cord-016364-80l5mua2 265 3 forensic forensic JJ cord-016364-80l5mua2 265 4 typing typing NN cord-016364-80l5mua2 265 5 system system NN cord-016364-80l5mua2 265 6 for for IN cord-016364-80l5mua2 265 7 genetic genetic JJ cord-016364-80l5mua2 265 8 individualization individualization NN cord-016364-80l5mua2 265 9 of of IN cord-016364-80l5mua2 265 10 domestic domestic JJ cord-016364-80l5mua2 265 11 cat cat NN cord-016364-80l5mua2 265 12 ( ( -LRB- cord-016364-80l5mua2 265 13 Felis Felis NNP cord-016364-80l5mua2 265 14 catus catus NN cord-016364-80l5mua2 265 15 ) ) -RRB- cord-016364-80l5mua2 266 1 samples sample NNS cord-016364-80l5mua2 266 2 Tyrosinase Tyrosinase NNP cord-016364-80l5mua2 266 3 and and CC cord-016364-80l5mua2 266 4 tyrosinase tyrosinase NN cord-016364-80l5mua2 266 5 related relate VBN cord-016364-80l5mua2 266 6 protein protein NN cord-016364-80l5mua2 266 7 1 1 CD cord-016364-80l5mua2 266 8 alleles allele NNS cord-016364-80l5mua2 266 9 specify specify VBP cord-016364-80l5mua2 266 10 domestic domestic JJ cord-016364-80l5mua2 266 11 cat cat NN cord-016364-80l5mua2 266 12 coat coat NN cord-016364-80l5mua2 266 13 color color NN cord-016364-80l5mua2 266 14 phenotypes phenotype NNS cord-016364-80l5mua2 266 15 of of IN cord-016364-80l5mua2 266 16 the the DT cord-016364-80l5mua2 266 17 albino albino NN cord-016364-80l5mua2 266 18 and and CC cord-016364-80l5mua2 266 19 brown brown JJ cord-016364-80l5mua2 266 20 loci locus NNS cord-016364-80l5mua2 266 21 Feline feline JJ cord-016364-80l5mua2 266 22 polycystic polycystic JJ cord-016364-80l5mua2 266 23 kidney kidney NN cord-016364-80l5mua2 266 24 disease disease NN cord-016364-80l5mua2 266 25 mutation mutation NN cord-016364-80l5mua2 266 26 identified identify VBN cord-016364-80l5mua2 266 27 in in IN cord-016364-80l5mua2 266 28 PKD1 PKD1 NNP cord-016364-80l5mua2 267 1 An an DT cord-016364-80l5mua2 267 2 ∼140-kb ∼140-kb NNS cord-016364-80l5mua2 267 3 deletion deletion NN cord-016364-80l5mua2 267 4 associated associate VBN cord-016364-80l5mua2 267 5 with with IN cord-016364-80l5mua2 267 6 feline feline JJ cord-016364-80l5mua2 267 7 spinal spinal JJ cord-016364-80l5mua2 267 8 muscular muscular JJ cord-016364-80l5mua2 267 9 atrophy atrophy NN cord-016364-80l5mua2 267 10 implies imply VBZ cord-016364-80l5mua2 267 11 an an DT cord-016364-80l5mua2 267 12 essential essential JJ cord-016364-80l5mua2 267 13 LIX1 LIX1 NNP cord-016364-80l5mua2 267 14 function function NN cord-016364-80l5mua2 267 15 for for IN cord-016364-80l5mua2 267 16 motor motor NN cord-016364-80l5mua2 267 17 neuron neuron NN cord-016364-80l5mua2 267 18 survival survival NN cord-016364-80l5mua2 268 1 A a DT cord-016364-80l5mua2 268 2 homozygous homozygous JJ cord-016364-80l5mua2 268 3 single single JJ cord-016364-80l5mua2 268 4 - - HYPH cord-016364-80l5mua2 268 5 base base NN cord-016364-80l5mua2 268 6 deletion deletion NN cord-016364-80l5mua2 268 7 in in IN cord-016364-80l5mua2 268 8 MLPH MLPH NNP cord-016364-80l5mua2 268 9 causes cause VBZ cord-016364-80l5mua2 268 10 the the DT cord-016364-80l5mua2 268 11 dilute dilute JJ cord-016364-80l5mua2 268 12 coat coat NN cord-016364-80l5mua2 268 13 color color NN cord-016364-80l5mua2 268 14 phenotype phenotype NN cord-016364-80l5mua2 268 15 in in IN cord-016364-80l5mua2 268 16 the the DT cord-016364-80l5mua2 268 17 domestic domestic JJ cord-016364-80l5mua2 268 18 cat cat NN cord-016364-80l5mua2 268 19 Albinism albinism NN cord-016364-80l5mua2 268 20 in in IN cord-016364-80l5mua2 268 21 the the DT cord-016364-80l5mua2 268 22 domestic domestic JJ cord-016364-80l5mua2 268 23 cat cat NN cord-016364-80l5mua2 268 24 ( ( -LRB- cord-016364-80l5mua2 268 25 Felis Felis NNP cord-016364-80l5mua2 268 26 catus catus NN cord-016364-80l5mua2 268 27 ) ) -RRB- cord-016364-80l5mua2 268 28 is be VBZ cord-016364-80l5mua2 268 29 associated associate VBN cord-016364-80l5mua2 268 30 with with IN cord-016364-80l5mua2 268 31 a a DT cord-016364-80l5mua2 268 32 tyrosinase tyrosinase NN cord-016364-80l5mua2 268 33 ( ( -LRB- cord-016364-80l5mua2 268 34 TYR TYR NNP cord-016364-80l5mua2 268 35 ) ) -RRB- cord-016364-80l5mua2 268 36 mutation mutation NN cord-016364-80l5mua2 268 37 Tyrosinase Tyrosinase NNP cord-016364-80l5mua2 268 38 mutations mutation NNS cord-016364-80l5mua2 268 39 associated associate VBN cord-016364-80l5mua2 268 40 with with IN cord-016364-80l5mua2 268 41 Siamese siamese JJ cord-016364-80l5mua2 268 42 and and CC cord-016364-80l5mua2 268 43 Burmese burmese JJ cord-016364-80l5mua2 268 44 patterns pattern NNS cord-016364-80l5mua2 268 45 in in IN cord-016364-80l5mua2 268 46 the the DT cord-016364-80l5mua2 268 47 domestic domestic JJ cord-016364-80l5mua2 268 48 cat cat NN cord-016364-80l5mua2 268 49 ( ( -LRB- cord-016364-80l5mua2 268 50 Felis Felis NNP cord-016364-80l5mua2 268 51 catus catus NN cord-016364-80l5mua2 268 52 ) ) -RRB- cord-016364-80l5mua2 269 1 Molecular molecular JJ cord-016364-80l5mua2 269 2 diagnosis diagnosis NN cord-016364-80l5mua2 269 3 of of IN cord-016364-80l5mua2 269 4 gangliosidosis gangliosidosis NNP cord-016364-80l5mua2 269 5 : : : cord-016364-80l5mua2 270 1 A a DT cord-016364-80l5mua2 270 2 model model NN cord-016364-80l5mua2 270 3 of of IN cord-016364-80l5mua2 270 4 inherited inherit VBN cord-016364-80l5mua2 270 5 diseases disease NNS cord-016364-80l5mua2 270 6 in in IN cord-016364-80l5mua2 270 7 pure pure JJ cord-016364-80l5mua2 270 8 breeds breed NNS cord-016364-80l5mua2 270 9 Characterization characterization NN cord-016364-80l5mua2 270 10 of of IN cord-016364-80l5mua2 270 11 the the DT cord-016364-80l5mua2 270 12 molecular molecular JJ cord-016364-80l5mua2 270 13 defect defect NN cord-016364-80l5mua2 270 14 in in IN cord-016364-80l5mua2 270 15 a a DT cord-016364-80l5mua2 270 16 feline feline JJ cord-016364-80l5mua2 270 17 model model NN cord-016364-80l5mua2 270 18 for for IN cord-016364-80l5mua2 270 19 type type NN cord-016364-80l5mua2 270 20 II II NNP cord-016364-80l5mua2 270 21 GM2-gangliosidosis gm2-gangliosidosis NN cord-016364-80l5mua2 270 22 ( ( -LRB- cord-016364-80l5mua2 270 23 Sandhoff Sandhoff NNP cord-016364-80l5mua2 270 24 disease disease NN cord-016364-80l5mua2 270 25 ) ) -RRB- cord-016364-80l5mua2 271 1 An an DT cord-016364-80l5mua2 271 2 inversion inversion NN cord-016364-80l5mua2 271 3 of of IN cord-016364-80l5mua2 271 4 25 25 CD cord-016364-80l5mua2 271 5 base base NN cord-016364-80l5mua2 271 6 pairs pair NNS cord-016364-80l5mua2 271 7 causes cause VBZ cord-016364-80l5mua2 271 8 feline feline JJ cord-016364-80l5mua2 271 9 GM2 GM2 NNP cord-016364-80l5mua2 271 10 gangliosidosis gangliosidosis NNP cord-016364-80l5mua2 271 11 variant variant NN cord-016364-80l5mua2 271 12 Mutation Mutation NNP cord-016364-80l5mua2 271 13 of of IN cord-016364-80l5mua2 271 14 the the DT cord-016364-80l5mua2 271 15 GM2 GM2 NNP cord-016364-80l5mua2 271 16 activator activator NN cord-016364-80l5mua2 271 17 protein protein NN cord-016364-80l5mua2 271 18 in in IN cord-016364-80l5mua2 271 19 a a DT cord-016364-80l5mua2 271 20 feline feline JJ cord-016364-80l5mua2 271 21 model model NN cord-016364-80l5mua2 271 22 of of IN cord-016364-80l5mua2 271 23 GM2 GM2 NNP cord-016364-80l5mua2 271 24 gangliosidosis gangliosidosis NNP cord-016364-80l5mua2 271 25 Glycogen Glycogen NNP cord-016364-80l5mua2 271 26 storage storage NN cord-016364-80l5mua2 271 27 disease disease NN cord-016364-80l5mua2 271 28 Type type NN cord-016364-80l5mua2 271 29 IV IV NNP cord-016364-80l5mua2 271 30 : : : cord-016364-80l5mua2 272 1 Inherited inherit VBN cord-016364-80l5mua2 272 2 deficiency deficiency NN cord-016364-80l5mua2 272 3 of of IN cord-016364-80l5mua2 272 4 branching branch VBG cord-016364-80l5mua2 272 5 enzyme enzyme NN cord-016364-80l5mua2 272 6 activity activity NN cord-016364-80l5mua2 272 7 in in IN cord-016364-80l5mua2 272 8 cats cat NNS cord-016364-80l5mua2 272 9 Glycogen Glycogen NNP cord-016364-80l5mua2 272 10 storage storage NN cord-016364-80l5mua2 272 11 disease disease NN cord-016364-80l5mua2 272 12 Type Type NNP cord-016364-80l5mua2 272 13 IV IV NNP cord-016364-80l5mua2 272 14 in in IN cord-016364-80l5mua2 272 15 Norwegian Norwegian NNP cord-016364-80l5mua2 272 16 Forest Forest NNP cord-016364-80l5mua2 272 17 Cats Cats NNPS cord-016364-80l5mua2 272 18 : : : cord-016364-80l5mua2 272 19 Molecular molecular JJ cord-016364-80l5mua2 272 20 detection detection NN cord-016364-80l5mua2 272 21 of of IN cord-016364-80l5mua2 272 22 carriers carrier NNS cord-016364-80l5mua2 272 23 Characterization characterization NN cord-016364-80l5mua2 272 24 of of IN cord-016364-80l5mua2 272 25 the the DT cord-016364-80l5mua2 272 26 mutations mutation NNS cord-016364-80l5mua2 272 27 causing cause VBG cord-016364-80l5mua2 272 28 hemophilia hemophilia NN cord-016364-80l5mua2 272 29 B B NNP cord-016364-80l5mua2 272 30 in in IN cord-016364-80l5mua2 272 31 2 2 CD cord-016364-80l5mua2 272 32 domestic domestic JJ cord-016364-80l5mua2 272 33 cats cat NNS cord-016364-80l5mua2 273 1 A a DT cord-016364-80l5mua2 273 2 mutation mutation NN cord-016364-80l5mua2 273 3 in in IN cord-016364-80l5mua2 273 4 the the DT cord-016364-80l5mua2 273 5 lipoprotein lipoprotein NN cord-016364-80l5mua2 273 6 lipase lipase NN cord-016364-80l5mua2 273 7 gene gene NN cord-016364-80l5mua2 273 8 is be VBZ cord-016364-80l5mua2 273 9 the the DT cord-016364-80l5mua2 273 10 molecular molecular JJ cord-016364-80l5mua2 273 11 basis basis NN cord-016364-80l5mua2 273 12 of of IN cord-016364-80l5mua2 273 13 chylomicronemia chylomicronemia NN cord-016364-80l5mua2 273 14 in in IN cord-016364-80l5mua2 273 15 a a DT cord-016364-80l5mua2 273 16 colony colony NN cord-016364-80l5mua2 273 17 of of IN cord-016364-80l5mua2 273 18 domestic domestic JJ cord-016364-80l5mua2 273 19 cats cat NNS cord-016364-80l5mua2 274 1 A a DT cord-016364-80l5mua2 274 2 cardiac cardiac JJ cord-016364-80l5mua2 274 3 myosin myosin NN cord-016364-80l5mua2 274 4 binding bind VBG cord-016364-80l5mua2 274 5 protein protein NN cord-016364-80l5mua2 274 6 C C NNP cord-016364-80l5mua2 274 7 mutation mutation NN cord-016364-80l5mua2 274 8 in in IN cord-016364-80l5mua2 274 9 the the DT cord-016364-80l5mua2 274 10 Maine Maine NNP cord-016364-80l5mua2 274 11 Coon Coon NNP cord-016364-80l5mua2 274 12 cat cat NN cord-016364-80l5mua2 274 13 with with IN cord-016364-80l5mua2 274 14 familial familial JJ cord-016364-80l5mua2 274 15 hypertrophic hypertrophic JJ cord-016364-80l5mua2 274 16 cardiomyopathy cardiomyopathy NN cord-016364-80l5mua2 275 1 A a DT cord-016364-80l5mua2 275 2 missense missense JJ cord-016364-80l5mua2 275 3 mutation mutation NN cord-016364-80l5mua2 275 4 in in IN cord-016364-80l5mua2 275 5 Nacetylglucosamine-1-phosphotransferase Nacetylglucosamine-1-phosphotransferase NNP cord-016364-80l5mua2 275 6 causes cause VBZ cord-016364-80l5mua2 275 7 mucolipidosis mucolipidosis NNP cord-016364-80l5mua2 275 8 II II NNP cord-016364-80l5mua2 275 9 in in IN cord-016364-80l5mua2 275 10 domestic domestic JJ cord-016364-80l5mua2 275 11 shorthair shorthair JJ cord-016364-80l5mua2 275 12 cats cat NNS cord-016364-80l5mua2 275 13 Two two CD cord-016364-80l5mua2 275 14 mutations mutation NNS cord-016364-80l5mua2 275 15 within within IN cord-016364-80l5mua2 275 16 a a DT cord-016364-80l5mua2 275 17 feline feline JJ cord-016364-80l5mua2 275 18 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 275 19 type type NN cord-016364-80l5mua2 275 20 VI VI NNP cord-016364-80l5mua2 275 21 colony colony NN cord-016364-80l5mua2 275 22 cause cause VB cord-016364-80l5mua2 275 23 three three CD cord-016364-80l5mua2 275 24 different different JJ cord-016364-80l5mua2 275 25 clinical clinical JJ cord-016364-80l5mua2 275 26 phenotypes phenotype NNS cord-016364-80l5mua2 275 27 Molecular molecular JJ cord-016364-80l5mua2 275 28 basis basis NN cord-016364-80l5mua2 275 29 of of IN cord-016364-80l5mua2 275 30 feline feline JJ cord-016364-80l5mua2 275 31 beta beta NN cord-016364-80l5mua2 275 32 - - HYPH cord-016364-80l5mua2 275 33 glucuronidase glucuronidase NN cord-016364-80l5mua2 275 34 deficiency deficiency NN cord-016364-80l5mua2 275 35 : : : cord-016364-80l5mua2 276 1 An an DT cord-016364-80l5mua2 276 2 animal animal NN cord-016364-80l5mua2 276 3 model model NN cord-016364-80l5mua2 276 4 of of IN cord-016364-80l5mua2 276 5 mucopolysaccharidosis mucopolysaccharidosis NNP cord-016364-80l5mua2 276 6 VII VII NNP cord-016364-80l5mua2 276 7 Deletion deletion NN cord-016364-80l5mua2 276 8 of of IN cord-016364-80l5mua2 276 9 the the DT cord-016364-80l5mua2 276 10 dystrophin dystrophin NN cord-016364-80l5mua2 276 11 muscle muscle NN cord-016364-80l5mua2 276 12 promoter promoter NN cord-016364-80l5mua2 276 13 in in IN cord-016364-80l5mua2 276 14 feline feline JJ cord-016364-80l5mua2 276 15 muscular muscular JJ cord-016364-80l5mua2 276 16 dystrophy dystrophy NN cord-016364-80l5mua2 276 17 Mutation Mutation NNP cord-016364-80l5mua2 276 18 analysis analysis NN cord-016364-80l5mua2 276 19 of of IN cord-016364-80l5mua2 276 20 feline feline JJ cord-016364-80l5mua2 276 21 Niemann Niemann NNP cord-016364-80l5mua2 276 22 - - HYPH cord-016364-80l5mua2 276 23 Pick Pick NNP cord-016364-80l5mua2 276 24 C1 C1 NNP cord-016364-80l5mua2 276 25 disease disease NN cord-016364-80l5mua2 276 26 A a DT cord-016364-80l5mua2 276 27 tyrosinase tyrosinase NN cord-016364-80l5mua2 276 28 gene gene NN cord-016364-80l5mua2 276 29 missense missense NN cord-016364-80l5mua2 276 30 mutation mutation NN cord-016364-80l5mua2 276 31 in in IN cord-016364-80l5mua2 276 32 temperature temperature NN cord-016364-80l5mua2 276 33 - - HYPH cord-016364-80l5mua2 276 34 sensitive sensitive JJ cord-016364-80l5mua2 276 35 type type NN cord-016364-80l5mua2 277 1 I -PRON- PRP cord-016364-80l5mua2 277 2 oculocutaneous oculocutaneous JJ cord-016364-80l5mua2 277 3 albinism albinism NN cord-016364-80l5mua2 277 4 . . . cord-016364-80l5mua2 278 1 A a DT cord-016364-80l5mua2 278 2 human human JJ cord-016364-80l5mua2 278 3 homologue homologue NN cord-016364-80l5mua2 278 4 to to IN cord-016364-80l5mua2 278 5 the the DT cord-016364-80l5mua2 278 6 Siamese siamese JJ cord-016364-80l5mua2 278 7 cat cat NN cord-016364-80l5mua2 278 8 and and CC cord-016364-80l5mua2 278 9 the the DT cord-016364-80l5mua2 278 10 Himalayan Himalayan NNP cord-016364-80l5mua2 278 11 mouse mouse NN cord-016364-80l5mua2 278 12 Molecular molecular JJ cord-016364-80l5mua2 278 13 basis basis NN cord-016364-80l5mua2 278 14 of of IN cord-016364-80l5mua2 278 15 erythrocyte erythrocyte NN cord-016364-80l5mua2 278 16 pyruvate pyruvate NN cord-016364-80l5mua2 278 17 kinase kinase NN cord-016364-80l5mua2 278 18 ( ( -LRB- cord-016364-80l5mua2 278 19 RPK RPK NNP cord-016364-80l5mua2 278 20 ) ) -RRB- cord-016364-80l5mua2 278 21 deficiency deficiency NN cord-016364-80l5mua2 278 22 in in IN cord-016364-80l5mua2 278 23 cats cat NNS cord-016364-80l5mua2 278 24 Cats Cats NNPS cord-016364-80l5mua2 278 25 lack lack VBP cord-016364-80l5mua2 278 26 a a DT cord-016364-80l5mua2 278 27 sweet sweet JJ cord-016364-80l5mua2 278 28 taste taste NN cord-016364-80l5mua2 278 29 receptor receptor NN cord-016364-80l5mua2 278 30 Nomenclature nomenclature NN cord-016364-80l5mua2 278 31 for for IN cord-016364-80l5mua2 278 32 the the DT cord-016364-80l5mua2 278 33 description description NN cord-016364-80l5mua2 278 34 of of IN cord-016364-80l5mua2 278 35 human human JJ cord-016364-80l5mua2 278 36 sequence sequence NN cord-016364-80l5mua2 278 37 variations variation VBZ cord-016364-80l5mua2 278 38 Spinal spinal JJ cord-016364-80l5mua2 278 39 muscular muscular JJ cord-016364-80l5mua2 278 40 atrophy atrophy NN cord-016364-80l5mua2 278 41 Identifi Identifi NNP cord-016364-80l5mua2 278 42 cation cation NN cord-016364-80l5mua2 278 43 and and CC cord-016364-80l5mua2 278 44 characterization characterization NN cord-016364-80l5mua2 278 45 of of IN cord-016364-80l5mua2 278 46 a a DT cord-016364-80l5mua2 278 47 spinal spinal JJ cord-016364-80l5mua2 278 48 muscular muscular JJ cord-016364-80l5mua2 278 49 atrophy atrophy NN cord-016364-80l5mua2 278 50 - - HYPH cord-016364-80l5mua2 278 51 determining determine VBG cord-016364-80l5mua2 278 52 gene gene NN cord-016364-80l5mua2 278 53 Quantitative quantitative JJ cord-016364-80l5mua2 278 54 analysis analysis NN cord-016364-80l5mua2 278 55 of of IN cord-016364-80l5mua2 278 56 survival survival NN cord-016364-80l5mua2 278 57 motor motor NN cord-016364-80l5mua2 278 58 neuron neuron NN cord-016364-80l5mua2 278 59 copies copy NNS cord-016364-80l5mua2 278 60 : : : cord-016364-80l5mua2 278 61 Identification identification NN cord-016364-80l5mua2 278 62 of of IN cord-016364-80l5mua2 278 63 subtle subtle JJ cord-016364-80l5mua2 278 64 SMN1 SMN1 NNP cord-016364-80l5mua2 278 65 mutations mutation NNS cord-016364-80l5mua2 278 66 in in IN cord-016364-80l5mua2 278 67 patients patient NNS cord-016364-80l5mua2 278 68 with with IN cord-016364-80l5mua2 278 69 spinal spinal JJ cord-016364-80l5mua2 278 70 muscular muscular JJ cord-016364-80l5mua2 278 71 atrophy atrophy NN cord-016364-80l5mua2 278 72 , , , cord-016364-80l5mua2 278 73 genotype genotype NN cord-016364-80l5mua2 278 74 - - HYPH cord-016364-80l5mua2 278 75 phenotype phenotype NN cord-016364-80l5mua2 278 76 correlation correlation NN cord-016364-80l5mua2 278 77 , , , cord-016364-80l5mua2 278 78 and and CC cord-016364-80l5mua2 278 79 implications implication NNS cord-016364-80l5mua2 278 80 for for IN cord-016364-80l5mua2 278 81 genetic genetic JJ cord-016364-80l5mua2 278 82 counseling counseling NN cord-016364-80l5mua2 279 1 Inherited inherit VBN cord-016364-80l5mua2 279 2 motor motor NN cord-016364-80l5mua2 279 3 neuron neuron NN cord-016364-80l5mua2 279 4 disease disease NN cord-016364-80l5mua2 279 5 in in IN cord-016364-80l5mua2 279 6 domestic domestic JJ cord-016364-80l5mua2 279 7 cats cat NNS cord-016364-80l5mua2 279 8 : : : cord-016364-80l5mua2 280 1 A a DT cord-016364-80l5mua2 280 2 model model NN cord-016364-80l5mua2 280 3 of of IN cord-016364-80l5mua2 280 4 spinal spinal JJ cord-016364-80l5mua2 280 5 muscular muscular JJ cord-016364-80l5mua2 280 6 atrophy atrophy NN cord-016364-80l5mua2 280 7 Assisted Assisted NNP cord-016364-80l5mua2 280 8 RNP RNP NNP cord-016364-80l5mua2 280 9 assembly assembly NN cord-016364-80l5mua2 280 10 : : : cord-016364-80l5mua2 281 1 SMN SMN NNP cord-016364-80l5mua2 281 2 and and CC cord-016364-80l5mua2 281 3 PRMT5 prmt5 JJ cord-016364-80l5mua2 281 4 complexes complex NNS cord-016364-80l5mua2 281 5 cooperate cooperate VBP cord-016364-80l5mua2 281 6 in in IN cord-016364-80l5mua2 281 7 the the DT cord-016364-80l5mua2 281 8 formation formation NN cord-016364-80l5mua2 281 9 of of IN cord-016364-80l5mua2 281 10 spliceosomal spliceosomal NNP cord-016364-80l5mua2 281 11 UsnRNPs UsnRNPs NNP cord-016364-80l5mua2 281 12 Animal Animal NNP cord-016364-80l5mua2 281 13 models model NNS cord-016364-80l5mua2 281 14 for for IN cord-016364-80l5mua2 281 15 mucopolysaccharidoses mucopolysaccharidose NNS cord-016364-80l5mua2 281 16 and and CC cord-016364-80l5mua2 281 17 their -PRON- PRP$ cord-016364-80l5mua2 281 18 clinical clinical JJ cord-016364-80l5mua2 281 19 relevance relevance NN cord-016364-80l5mua2 281 20 Chromosomal chromosomal JJ cord-016364-80l5mua2 281 21 mapping mapping NN cord-016364-80l5mua2 281 22 of of IN cord-016364-80l5mua2 281 23 lysosomal lysosomal JJ cord-016364-80l5mua2 281 24 enzyme enzyme NN cord-016364-80l5mua2 281 25 structural structural JJ cord-016364-80l5mua2 281 26 genes gene NNS cord-016364-80l5mua2 281 27 in in IN cord-016364-80l5mua2 281 28 the the DT cord-016364-80l5mua2 281 29 domestic domestic JJ cord-016364-80l5mua2 281 30 cat cat NN cord-016364-80l5mua2 281 31 Gene Gene NNP cord-016364-80l5mua2 281 32 therapy therapy NN cord-016364-80l5mua2 281 33 for for IN cord-016364-80l5mua2 281 34 lysosomal lysosomal JJ cord-016364-80l5mua2 281 35 storage storage NN cord-016364-80l5mua2 281 36 diseases disease NNS cord-016364-80l5mua2 281 37 : : : cord-016364-80l5mua2 282 1 The the DT cord-016364-80l5mua2 282 2 lessons lesson NNS cord-016364-80l5mua2 282 3 and and CC cord-016364-80l5mua2 282 4 promise promise NN cord-016364-80l5mua2 282 5 of of IN cord-016364-80l5mua2 282 6 animal animal NN cord-016364-80l5mua2 282 7 models model NNS cord-016364-80l5mua2 282 8 Inherited inherit VBN cord-016364-80l5mua2 282 9 disorders disorder NNS cord-016364-80l5mua2 282 10 of of IN cord-016364-80l5mua2 282 11 lysosomal lysosomal JJ cord-016364-80l5mua2 282 12 metabolism metabolism NN cord-016364-80l5mua2 282 13 Alpha Alpha NNP cord-016364-80l5mua2 282 14 - - HYPH cord-016364-80l5mua2 282 15 L l NN cord-016364-80l5mua2 282 16 - - HYPH cord-016364-80l5mua2 282 17 iduronidase iduronidase JJ cord-016364-80l5mua2 282 18 deficiency deficiency NN cord-016364-80l5mua2 282 19 in in IN cord-016364-80l5mua2 282 20 a a DT cord-016364-80l5mua2 282 21 cat cat NN cord-016364-80l5mua2 282 22 : : : cord-016364-80l5mua2 282 23 A a DT cord-016364-80l5mua2 282 24 model model NN cord-016364-80l5mua2 282 25 of of IN cord-016364-80l5mua2 282 26 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 282 27 I I NNP cord-016364-80l5mua2 282 28 Mucopolysaccharidosis Mucopolysaccharidosis NNP cord-016364-80l5mua2 282 29 in in IN cord-016364-80l5mua2 282 30 a a DT cord-016364-80l5mua2 282 31 domestic domestic JJ cord-016364-80l5mua2 282 32 short short JJ cord-016364-80l5mua2 282 33 - - HYPH cord-016364-80l5mua2 282 34 haired haired JJ cord-016364-80l5mua2 282 35 cat cat NN cord-016364-80l5mua2 282 36 - - : cord-016364-80l5mua2 282 37 a a DT cord-016364-80l5mua2 282 38 disease disease NN cord-016364-80l5mua2 282 39 distinct distinct JJ cord-016364-80l5mua2 282 40 from from IN cord-016364-80l5mua2 282 41 that that DT cord-016364-80l5mua2 282 42 seen see VBN cord-016364-80l5mua2 282 43 in in IN cord-016364-80l5mua2 282 44 the the DT cord-016364-80l5mua2 282 45 Siamese siamese JJ cord-016364-80l5mua2 282 46 cat cat NN cord-016364-80l5mua2 283 1 A a DT cord-016364-80l5mua2 283 2 canine canine JJ cord-016364-80l5mua2 283 3 model model NN cord-016364-80l5mua2 283 4 of of IN cord-016364-80l5mua2 283 5 human human JJ cord-016364-80l5mua2 283 6 alpha alpha NN cord-016364-80l5mua2 283 7 - - HYPH cord-016364-80l5mua2 283 8 L l NN cord-016364-80l5mua2 283 9 - - HYPH cord-016364-80l5mua2 283 10 iduronidase iduronidase NNP cord-016364-80l5mua2 283 11 defi defi NNP cord-016364-80l5mua2 283 12 ciency ciency NNP cord-016364-80l5mua2 284 1 Mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 285 1 I -PRON- PRP cord-016364-80l5mua2 285 2 cats cat NNS cord-016364-80l5mua2 285 3 mount mount VBP cord-016364-80l5mua2 285 4 a a DT cord-016364-80l5mua2 285 5 cytotoxic cytotoxic JJ cord-016364-80l5mua2 285 6 T t NN cord-016364-80l5mua2 285 7 lymphocyte lymphocyte NN cord-016364-80l5mua2 285 8 response response NN cord-016364-80l5mua2 285 9 after after IN cord-016364-80l5mua2 285 10 neonatal neonatal JJ cord-016364-80l5mua2 285 11 gene gene NN cord-016364-80l5mua2 285 12 therapy therapy NN cord-016364-80l5mua2 285 13 that that WDT cord-016364-80l5mua2 285 14 can can MD cord-016364-80l5mua2 285 15 be be VB cord-016364-80l5mua2 285 16 blocked block VBN cord-016364-80l5mua2 285 17 with with IN cord-016364-80l5mua2 285 18 CTLA4-Ig CTLA4-Ig NNP cord-016364-80l5mua2 285 19 Mucopolysaccharidosis Mucopolysaccharidosis NNP cord-016364-80l5mua2 285 20 in in IN cord-016364-80l5mua2 285 21 a a DT cord-016364-80l5mua2 285 22 cat cat NN cord-016364-80l5mua2 286 1 Mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 286 2 in in IN cord-016364-80l5mua2 286 3 a a DT cord-016364-80l5mua2 286 4 cat cat NN cord-016364-80l5mua2 286 5 with with IN cord-016364-80l5mua2 286 6 arylsulfatase arylsulfatase NNP cord-016364-80l5mua2 286 7 B B NNP cord-016364-80l5mua2 286 8 defi defi NNP cord-016364-80l5mua2 286 9 ciency ciency NN cord-016364-80l5mua2 286 10 : : : cord-016364-80l5mua2 287 1 A a DT cord-016364-80l5mua2 287 2 model model NN cord-016364-80l5mua2 287 3 of of IN cord-016364-80l5mua2 287 4 Maroteaux Maroteaux NNP cord-016364-80l5mua2 287 5 - - HYPH cord-016364-80l5mua2 287 6 Lamy Lamy NNP cord-016364-80l5mua2 287 7 syndrome syndrome NN cord-016364-80l5mua2 287 8 Mucopolysaccharide Mucopolysaccharide NNP cord-016364-80l5mua2 287 9 storage storage NN cord-016364-80l5mua2 287 10 disease disease NN cord-016364-80l5mua2 287 11 in in IN cord-016364-80l5mua2 287 12 three three CD cord-016364-80l5mua2 287 13 families family NNS cord-016364-80l5mua2 287 14 of of IN cord-016364-80l5mua2 287 15 cats cat NNS cord-016364-80l5mua2 287 16 with with IN cord-016364-80l5mua2 287 17 arylsulfatase arylsulfatase NNP cord-016364-80l5mua2 287 18 B B NNP cord-016364-80l5mua2 287 19 defi defi NNP cord-016364-80l5mua2 287 20 ciency ciency NN cord-016364-80l5mua2 287 21 : : : cord-016364-80l5mua2 288 1 Leukocyte Leukocyte NNP cord-016364-80l5mua2 288 2 studies study NNS cord-016364-80l5mua2 288 3 and and CC cord-016364-80l5mua2 288 4 carrier carrier NNP cord-016364-80l5mua2 288 5 identifi identifi NNP cord-016364-80l5mua2 288 6 cation cation NNP cord-016364-80l5mua2 288 7 Animal Animal NNP cord-016364-80l5mua2 288 8 model model NN cord-016364-80l5mua2 288 9 of of IN cord-016364-80l5mua2 288 10 human human JJ cord-016364-80l5mua2 288 11 disease disease NN cord-016364-80l5mua2 288 12 : : : cord-016364-80l5mua2 289 1 Mucopolysaccharidosis Mucopolysaccharidosis NNP cord-016364-80l5mua2 289 2 VI VI NNP cord-016364-80l5mua2 289 3 Maroteaux Maroteaux NNP cord-016364-80l5mua2 289 4 - - HYPH cord-016364-80l5mua2 289 5 Lamy Lamy NNP cord-016364-80l5mua2 289 6 syndrome syndrome NN cord-016364-80l5mua2 289 7 , , , cord-016364-80l5mua2 289 8 arylsulfatase arylsulfatase NNP cord-016364-80l5mua2 289 9 B b NN cord-016364-80l5mua2 289 10 - - HYPH cord-016364-80l5mua2 289 11 deficient deficient JJ cord-016364-80l5mua2 289 12 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 289 13 in in IN cord-016364-80l5mua2 289 14 the the DT cord-016364-80l5mua2 289 15 Siamese siamese JJ cord-016364-80l5mua2 289 16 cat cat NN cord-016364-80l5mua2 289 17 Abnormal abnormal JJ cord-016364-80l5mua2 289 18 neuronal neuronal JJ cord-016364-80l5mua2 289 19 metabolism metabolism NN cord-016364-80l5mua2 289 20 and and CC cord-016364-80l5mua2 289 21 storage storage NN cord-016364-80l5mua2 289 22 in in IN cord-016364-80l5mua2 289 23 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 289 24 type type NN cord-016364-80l5mua2 289 25 VI VI NNP cord-016364-80l5mua2 289 26 ( ( -LRB- cord-016364-80l5mua2 289 27 Maroteaux Maroteaux NNP cord-016364-80l5mua2 289 28 - - HYPH cord-016364-80l5mua2 289 29 Lamy Lamy NNP cord-016364-80l5mua2 289 30 ) ) -RRB- cord-016364-80l5mua2 289 31 disease disease NNP cord-016364-80l5mua2 289 32 Evaluation Evaluation NNP cord-016364-80l5mua2 289 33 of of IN cord-016364-80l5mua2 289 34 fi fi NNP cord-016364-80l5mua2 289 35 broblast broblast RB cord-016364-80l5mua2 289 36 - - HYPH cord-016364-80l5mua2 289 37 mediated mediate VBN cord-016364-80l5mua2 289 38 gene gene NN cord-016364-80l5mua2 289 39 therapy therapy NN cord-016364-80l5mua2 289 40 in in IN cord-016364-80l5mua2 289 41 a a DT cord-016364-80l5mua2 289 42 feline feline JJ cord-016364-80l5mua2 289 43 model model NN cord-016364-80l5mua2 289 44 of of IN cord-016364-80l5mua2 289 45 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 289 46 type type NN cord-016364-80l5mua2 289 47 VI VI NNP cord-016364-80l5mua2 289 48 Phenotypic Phenotypic NNP cord-016364-80l5mua2 289 49 rescue rescue NN cord-016364-80l5mua2 289 50 after after IN cord-016364-80l5mua2 289 51 adeno adeno NN cord-016364-80l5mua2 289 52 - - HYPH cord-016364-80l5mua2 289 53 associated associate VBN cord-016364-80l5mua2 289 54 virus virus NN cord-016364-80l5mua2 289 55 - - HYPH cord-016364-80l5mua2 289 56 mediated mediate VBN cord-016364-80l5mua2 289 57 delivery delivery NN cord-016364-80l5mua2 289 58 of of IN cord-016364-80l5mua2 289 59 4-sulfatase 4-sulfatase CD cord-016364-80l5mua2 289 60 to to IN cord-016364-80l5mua2 289 61 the the DT cord-016364-80l5mua2 289 62 retinal retinal JJ cord-016364-80l5mua2 289 63 pigment pigment NN cord-016364-80l5mua2 289 64 epithelium epithelium NN cord-016364-80l5mua2 289 65 of of IN cord-016364-80l5mua2 289 66 feline feline JJ cord-016364-80l5mua2 289 67 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 289 68 VI VI NNP cord-016364-80l5mua2 290 1 The the DT cord-016364-80l5mua2 290 2 Metabolic Metabolic NNP cord-016364-80l5mua2 290 3 and and CC cord-016364-80l5mua2 290 4 Molecular Molecular NNP cord-016364-80l5mua2 290 5 Basis Basis NNP cord-016364-80l5mua2 290 6 of of IN cord-016364-80l5mua2 290 7 Inherited Inherited NNP cord-016364-80l5mua2 290 8 Disease Disease NNP cord-016364-80l5mua2 290 9 Beta Beta NNP cord-016364-80l5mua2 290 10 - - HYPH cord-016364-80l5mua2 290 11 glucuronidase glucuronidase NN cord-016364-80l5mua2 290 12 deficiency deficiency NN cord-016364-80l5mua2 290 13 in in IN cord-016364-80l5mua2 290 14 a a DT cord-016364-80l5mua2 290 15 dog dog NN cord-016364-80l5mua2 290 16 : : : cord-016364-80l5mua2 290 17 A a DT cord-016364-80l5mua2 290 18 model model NN cord-016364-80l5mua2 290 19 of of IN cord-016364-80l5mua2 290 20 human human JJ cord-016364-80l5mua2 290 21 mucopolysaccharidosis mucopolysaccharidosis NNP cord-016364-80l5mua2 290 22 VII VII NNP cord-016364-80l5mua2 290 23 Feline Feline NNP cord-016364-80l5mua2 290 24 mucopolysaccharidosis mucopolysaccharidosis NN cord-016364-80l5mua2 290 25 VII VII NNP cord-016364-80l5mua2 290 26 due due IN cord-016364-80l5mua2 290 27 to to IN cord-016364-80l5mua2 290 28 beta beta NN cord-016364-80l5mua2 290 29 - - HYPH cord-016364-80l5mua2 290 30 glucuronidase glucuronidase NN cord-016364-80l5mua2 290 31 defi defi NNP cord-016364-80l5mua2 290 32 ciency ciency NNP cord-016364-80l5mua2 290 33 Adeno Adeno NNP cord-016364-80l5mua2 290 34 - - HYPH cord-016364-80l5mua2 290 35 associated associate VBN cord-016364-80l5mua2 290 36 virus virus NN cord-016364-80l5mua2 290 37 vector vector NN cord-016364-80l5mua2 290 38 - - HYPH cord-016364-80l5mua2 290 39 mediated mediate VBN cord-016364-80l5mua2 290 40 transduction transduction NN cord-016364-80l5mua2 290 41 in in IN cord-016364-80l5mua2 290 42 the the DT cord-016364-80l5mua2 290 43 cat cat NN cord-016364-80l5mua2 290 44 brain brain NN cord-016364-80l5mua2 290 45 Disorders disorder NNS cord-016364-80l5mua2 290 46 of of IN cord-016364-80l5mua2 290 47 glycoprotein glycoprotein NN cord-016364-80l5mua2 290 48 degradation degradation NN cord-016364-80l5mua2 290 49 : : : cord-016364-80l5mua2 290 50 α α NN cord-016364-80l5mua2 290 51 - - HYPH cord-016364-80l5mua2 290 52 Mannosidosis Mannosidosis NNP cord-016364-80l5mua2 290 53 , , , cord-016364-80l5mua2 290 54 β β NN cord-016364-80l5mua2 290 55 - - HYPH cord-016364-80l5mua2 290 56 mannosidosis mannosidosis NNP cord-016364-80l5mua2 290 57 , , , cord-016364-80l5mua2 290 58 sialidosis sialidosis NNP cord-016364-80l5mua2 290 59 , , , cord-016364-80l5mua2 290 60 aspartylglucosaminuria aspartylglucosaminuria NNP cord-016364-80l5mua2 290 61 , , , cord-016364-80l5mua2 290 62 and and CC cord-016364-80l5mua2 290 63 carbohydrate carbohydrate NN cord-016364-80l5mua2 290 64 - - HYPH cord-016364-80l5mua2 290 65 deficient deficient JJ cord-016364-80l5mua2 290 66 glycoprotein glycoprotein NN cord-016364-80l5mua2 290 67 syndrome syndrome NN cord-016364-80l5mua2 290 68 Biochemical biochemical JJ cord-016364-80l5mua2 290 69 studies study NNS cord-016364-80l5mua2 290 70 on on IN cord-016364-80l5mua2 290 71 a a DT cord-016364-80l5mua2 290 72 case case NN cord-016364-80l5mua2 290 73 of of IN cord-016364-80l5mua2 290 74 feline feline JJ cord-016364-80l5mua2 290 75 mannosidosis mannosidosis NN cord-016364-80l5mua2 290 76 Bone Bone NNP cord-016364-80l5mua2 290 77 marrow marrow NN cord-016364-80l5mua2 290 78 transplantation transplantation NN cord-016364-80l5mua2 290 79 corrects correct VBZ cord-016364-80l5mua2 290 80 the the DT cord-016364-80l5mua2 290 81 enzyme enzyme NN cord-016364-80l5mua2 290 82 defect defect NN cord-016364-80l5mua2 290 83 in in IN cord-016364-80l5mua2 290 84 neurons neuron NNS cord-016364-80l5mua2 290 85 of of IN cord-016364-80l5mua2 290 86 the the DT cord-016364-80l5mua2 290 87 central central JJ cord-016364-80l5mua2 290 88 nervous nervous JJ cord-016364-80l5mua2 290 89 system system NN cord-016364-80l5mua2 290 90 in in IN cord-016364-80l5mua2 290 91 a a DT cord-016364-80l5mua2 290 92 lysosomal lysosomal JJ cord-016364-80l5mua2 290 93 storage storage NN cord-016364-80l5mua2 290 94 disease disease NN cord-016364-80l5mua2 290 95 Bone Bone NNP cord-016364-80l5mua2 290 96 marrow marrow NN cord-016364-80l5mua2 290 97 transplantation transplantation NN cord-016364-80l5mua2 290 98 in in IN cord-016364-80l5mua2 290 99 animal animal NN cord-016364-80l5mua2 290 100 models model NNS cord-016364-80l5mua2 290 101 of of IN cord-016364-80l5mua2 290 102 lysosomal lysosomal JJ cord-016364-80l5mua2 290 103 storage storage NN cord-016364-80l5mua2 290 104 diseases disease NNS cord-016364-80l5mua2 290 105 Effective effective JJ cord-016364-80l5mua2 290 106 gene gene NN cord-016364-80l5mua2 290 107 therapy therapy NN cord-016364-80l5mua2 290 108 for for IN cord-016364-80l5mua2 290 109 an an DT cord-016364-80l5mua2 290 110 inherited inherit VBN cord-016364-80l5mua2 290 111 CNS CNS NNP cord-016364-80l5mua2 290 112 disease disease NN cord-016364-80l5mua2 290 113 in in IN cord-016364-80l5mua2 290 114 a a DT cord-016364-80l5mua2 290 115 large large JJ cord-016364-80l5mua2 290 116 animal animal NN cord-016364-80l5mua2 290 117 model model NN cord-016364-80l5mua2 290 118 Familial familial JJ cord-016364-80l5mua2 290 119 lipoprotein lipoprotein NN cord-016364-80l5mua2 290 120 lipase lipase NN cord-016364-80l5mua2 290 121 deficiency deficiency NN cord-016364-80l5mua2 290 122 and and CC cord-016364-80l5mua2 290 123 other other JJ cord-016364-80l5mua2 290 124 causes cause NNS cord-016364-80l5mua2 290 125 of of IN cord-016364-80l5mua2 290 126 the the DT cord-016364-80l5mua2 290 127 chylomicronemia chylomicronemia NNP cord-016364-80l5mua2 290 128 syndrome syndrome NN cord-016364-80l5mua2 290 129 Correction Correction NNP cord-016364-80l5mua2 290 130 of of IN cord-016364-80l5mua2 290 131 feline feline JJ cord-016364-80l5mua2 290 132 lipoprotein lipoprotein NN cord-016364-80l5mua2 290 133 lipase lipase NN cord-016364-80l5mua2 290 134 deficiency deficiency NN cord-016364-80l5mua2 290 135 with with IN cord-016364-80l5mua2 290 136 adeno adeno NN cord-016364-80l5mua2 290 137 - - HYPH cord-016364-80l5mua2 290 138 associated associate VBN cord-016364-80l5mua2 290 139 virus virus NN cord-016364-80l5mua2 290 140 serotype serotype NN cord-016364-80l5mua2 290 141 1-mediated 1-mediated CD cord-016364-80l5mua2 290 142 gene gene NN cord-016364-80l5mua2 290 143 transfer transfer NN cord-016364-80l5mua2 290 144 of of IN cord-016364-80l5mua2 290 145 the the DT cord-016364-80l5mua2 290 146 lipoprotein lipoprotein NN cord-016364-80l5mua2 290 147 lipase lipase NN cord-016364-80l5mua2 290 148 S447X S447X NNP cord-016364-80l5mua2 290 149 beneficial beneficial JJ cord-016364-80l5mua2 290 150 mutation mutation NN cord-016364-80l5mua2 290 151 Characterization characterization NN cord-016364-80l5mua2 290 152 of of IN cord-016364-80l5mua2 290 153 a a DT cord-016364-80l5mua2 290 154 new new JJ cord-016364-80l5mua2 290 155 model model NN cord-016364-80l5mua2 290 156 of of IN cord-016364-80l5mua2 290 157 GM2 GM2 NNP cord-016364-80l5mua2 290 158 gangliosidosis gangliosidosis NNP cord-016364-80l5mua2 290 159 ( ( -LRB- cord-016364-80l5mua2 290 160 Sandhoff Sandhoff NNP cord-016364-80l5mua2 290 161 's 's POS cord-016364-80l5mua2 290 162 disease disease NN cord-016364-80l5mua2 290 163 ) ) -RRB- cord-016364-80l5mua2 290 164 in in IN cord-016364-80l5mua2 290 165 Korat Korat NNP cord-016364-80l5mua2 290 166 cats cat NNS cord-016364-80l5mua2 291 1 The the DT cord-016364-80l5mua2 291 2 Metabolic Metabolic NNP cord-016364-80l5mua2 291 3 and and CC cord-016364-80l5mua2 291 4 Molecular Molecular NNP cord-016364-80l5mua2 291 5 Bases Bases NNPS cord-016364-80l5mua2 291 6 of of IN cord-016364-80l5mua2 291 7 Inherited Inherited NNP cord-016364-80l5mua2 291 8 Diseases Diseases NNP cord-016364-80l5mua2 291 9 GM2-gangliosidosis gm2-gangliosidosis NN cord-016364-80l5mua2 291 10 variant variant NN cord-016364-80l5mua2 291 11 0 0 NFP cord-016364-80l5mua2 291 12 ( ( -LRB- cord-016364-80l5mua2 291 13 Sandhoff Sandhoff NNP cord-016364-80l5mua2 291 14 - - HYPH cord-016364-80l5mua2 291 15 like like JJ cord-016364-80l5mua2 291 16 disease disease NN cord-016364-80l5mua2 291 17 ) ) -RRB- cord-016364-80l5mua2 291 18 in in IN cord-016364-80l5mua2 291 19 a a DT cord-016364-80l5mua2 291 20 family family NN cord-016364-80l5mua2 291 21 of of IN cord-016364-80l5mua2 291 22 Japanese japanese JJ cord-016364-80l5mua2 291 23 domestic domestic JJ cord-016364-80l5mua2 291 24 cats cat NNS cord-016364-80l5mua2 291 25 Inheritance Inheritance NNP cord-016364-80l5mua2 291 26 , , , cord-016364-80l5mua2 291 27 biochemical biochemical JJ cord-016364-80l5mua2 291 28 abnormalities abnormality NNS cord-016364-80l5mua2 291 29 , , , cord-016364-80l5mua2 291 30 and and CC cord-016364-80l5mua2 291 31 clinical clinical JJ cord-016364-80l5mua2 291 32 features feature NNS cord-016364-80l5mua2 291 33 of of IN cord-016364-80l5mua2 291 34 feline feline JJ cord-016364-80l5mua2 291 35 mucolipidosis mucolipidosis NN cord-016364-80l5mua2 291 36 II II NNP cord-016364-80l5mua2 291 37 : : : cord-016364-80l5mua2 291 38 The the DT cord-016364-80l5mua2 291 39 fi fi NN cord-016364-80l5mua2 291 40 rst rst NNP cord-016364-80l5mua2 291 41 animal animal NN cord-016364-80l5mua2 291 42 model model NN cord-016364-80l5mua2 291 43 of of IN cord-016364-80l5mua2 291 44 human human JJ cord-016364-80l5mua2 291 45 I i NN cord-016364-80l5mua2 291 46 - - HYPH cord-016364-80l5mua2 291 47 cell cell NN cord-016364-80l5mua2 291 48 disease disease NN cord-016364-80l5mua2 291 49 Congenital congenital JJ cord-016364-80l5mua2 291 50 diseases disease NNS cord-016364-80l5mua2 291 51 of of IN cord-016364-80l5mua2 291 52 feline feline JJ cord-016364-80l5mua2 291 53 muscle muscle NN cord-016364-80l5mua2 291 54 and and CC cord-016364-80l5mua2 291 55 neuromuscular neuromuscular JJ cord-016364-80l5mua2 291 56 junction junction NN cord-016364-80l5mua2 291 57 Hereditary hereditary JJ cord-016364-80l5mua2 291 58 myopathy myopathy NN cord-016364-80l5mua2 291 59 of of IN cord-016364-80l5mua2 291 60 Devon Devon NNP cord-016364-80l5mua2 291 61 Rex Rex NNP cord-016364-80l5mua2 291 62 cats cat NNS cord-016364-80l5mua2 291 63 Congenital congenital JJ cord-016364-80l5mua2 291 64 myotonia myotonia NN cord-016364-80l5mua2 291 65 in in IN cord-016364-80l5mua2 291 66 related related JJ cord-016364-80l5mua2 291 67 kittens kitten NNS cord-016364-80l5mua2 291 68 Congenital congenital JJ cord-016364-80l5mua2 291 69 myotonia myotonia NN cord-016364-80l5mua2 291 70 in in IN cord-016364-80l5mua2 291 71 2 2 CD cord-016364-80l5mua2 291 72 domestic domestic JJ cord-016364-80l5mua2 291 73 cats cat NNS cord-016364-80l5mua2 292 1 Laminin Laminin NNP cord-016364-80l5mua2 292 2 alpha alpha NN cord-016364-80l5mua2 292 3 2 2 CD cord-016364-80l5mua2 292 4 ( ( -LRB- cord-016364-80l5mua2 292 5 merosin)-defi merosin)-defi NNP cord-016364-80l5mua2 292 6 cient cient JJ cord-016364-80l5mua2 292 7 muscular muscular JJ cord-016364-80l5mua2 292 8 dystrophy dystrophy NN cord-016364-80l5mua2 292 9 and and CC cord-016364-80l5mua2 292 10 demyelinating demyelinating JJ cord-016364-80l5mua2 292 11 neuropathy neuropathy NN cord-016364-80l5mua2 292 12 in in IN cord-016364-80l5mua2 292 13 two two CD cord-016364-80l5mua2 292 14 cats cat NNS cord-016364-80l5mua2 292 15 Dystrophin Dystrophin NNP cord-016364-80l5mua2 292 16 : : : cord-016364-80l5mua2 293 1 The the DT cord-016364-80l5mua2 293 2 protein protein NN cord-016364-80l5mua2 293 3 product product NN cord-016364-80l5mua2 293 4 of of IN cord-016364-80l5mua2 293 5 the the DT cord-016364-80l5mua2 293 6 Duchenne Duchenne NNP cord-016364-80l5mua2 293 7 muscular muscular JJ cord-016364-80l5mua2 293 8 dystrophy dystrophy NN cord-016364-80l5mua2 293 9 locus locus NN cord-016364-80l5mua2 293 10 Dystrophin Dystrophin NNP cord-016364-80l5mua2 293 11 defi defi IN cord-016364-80l5mua2 293 12 ciency ciency NN cord-016364-80l5mua2 293 13 causes cause VBZ cord-016364-80l5mua2 293 14 lethal lethal JJ cord-016364-80l5mua2 293 15 muscle muscle NN cord-016364-80l5mua2 293 16 hypertrophy hypertrophy NN cord-016364-80l5mua2 293 17 in in IN cord-016364-80l5mua2 293 18 cats cat NNS cord-016364-80l5mua2 294 1 The the DT cord-016364-80l5mua2 294 2 complete complete JJ cord-016364-80l5mua2 294 3 sequence sequence NN cord-016364-80l5mua2 294 4 of of IN cord-016364-80l5mua2 294 5 dystrophin dystrophin NN cord-016364-80l5mua2 294 6 predicts predict VBZ cord-016364-80l5mua2 294 7 a a DT cord-016364-80l5mua2 294 8 rod rod NN cord-016364-80l5mua2 294 9 - - HYPH cord-016364-80l5mua2 294 10 shaped shape VBN cord-016364-80l5mua2 294 11 cytoskeletal cytoskeletal JJ cord-016364-80l5mua2 294 12 protein protein NN cord-016364-80l5mua2 294 13 Functional functional JJ cord-016364-80l5mua2 294 14 regeneration regeneration NN cord-016364-80l5mua2 294 15 in in IN cord-016364-80l5mua2 294 16 the the DT cord-016364-80l5mua2 294 17 hindlimb hindlimb NN cord-016364-80l5mua2 294 18 skeletal skeletal JJ cord-016364-80l5mua2 294 19 muscle muscle NN cord-016364-80l5mua2 294 20 of of IN cord-016364-80l5mua2 294 21 the the DT cord-016364-80l5mua2 294 22 mdx mdx NNP cord-016364-80l5mua2 294 23 mouse mouse NN cord-016364-80l5mua2 294 24 Feline feline JJ cord-016364-80l5mua2 294 25 muscular muscular JJ cord-016364-80l5mua2 294 26 dystrophy dystrophy NN cord-016364-80l5mua2 294 27 with with IN cord-016364-80l5mua2 294 28 dystrophin dystrophin NN cord-016364-80l5mua2 294 29 defi defi NNP cord-016364-80l5mua2 294 30 ciency ciency NNP cord-016364-80l5mua2 294 31 Muscular muscular JJ cord-016364-80l5mua2 294 32 dystrophies dystrophy NNS cord-016364-80l5mua2 294 33 : : : cord-016364-80l5mua2 294 34 Expanding expand VBG cord-016364-80l5mua2 294 35 our -PRON- PRP$ cord-016364-80l5mua2 294 36 knowledge knowledge NN cord-016364-80l5mua2 294 37 in in IN cord-016364-80l5mua2 294 38 companion companion NN cord-016364-80l5mua2 294 39 animals animal NNS cord-016364-80l5mua2 295 1 The the DT cord-016364-80l5mua2 295 2 molecular molecular JJ cord-016364-80l5mua2 295 3 genetic genetic JJ cord-016364-80l5mua2 295 4 basis basis NN cord-016364-80l5mua2 295 5 for for IN cord-016364-80l5mua2 295 6 hypertrophic hypertrophic JJ cord-016364-80l5mua2 295 7 cardiomyopathy cardiomyopathy NN cord-016364-80l5mua2 295 8 Large large JJ cord-016364-80l5mua2 295 9 animal animal NN cord-016364-80l5mua2 295 10 models model NNS cord-016364-80l5mua2 295 11 and and CC cord-016364-80l5mua2 295 12 gene gene NN cord-016364-80l5mua2 295 13 therapy therapy NN cord-016364-80l5mua2 295 14 Autologous autologous JJ cord-016364-80l5mua2 295 15 transplantation transplantation NN cord-016364-80l5mua2 295 16 of of IN cord-016364-80l5mua2 295 17 retrovirally retrovirally RB cord-016364-80l5mua2 295 18 transduced transduce VBN cord-016364-80l5mua2 295 19 bone bone NN cord-016364-80l5mua2 295 20 marrow marrow NN cord-016364-80l5mua2 295 21 or or CC cord-016364-80l5mua2 295 22 neonatal neonatal JJ cord-016364-80l5mua2 295 23 blood blood NN cord-016364-80l5mua2 295 24 cells cell NNS cord-016364-80l5mua2 295 25 into into IN cord-016364-80l5mua2 295 26 cats cat NNS cord-016364-80l5mua2 295 27 can can MD cord-016364-80l5mua2 295 28 lead lead VB cord-016364-80l5mua2 295 29 to to IN cord-016364-80l5mua2 295 30 long long JJ cord-016364-80l5mua2 295 31 - - HYPH cord-016364-80l5mua2 295 32 term term NN cord-016364-80l5mua2 295 33 engraftment engraftment NN cord-016364-80l5mua2 295 34 in in IN cord-016364-80l5mua2 295 35 the the DT cord-016364-80l5mua2 295 36 absence absence NN cord-016364-80l5mua2 295 37 of of IN cord-016364-80l5mua2 295 38 myeloablation myeloablation NN cord-016364-80l5mua2 295 39 Visual visual JJ cord-016364-80l5mua2 295 40 resolution resolution NN cord-016364-80l5mua2 295 41 with with IN cord-016364-80l5mua2 295 42 retinal retinal JJ cord-016364-80l5mua2 295 43 implants implant NNS cord-016364-80l5mua2 295 44 estimated estimate VBN cord-016364-80l5mua2 295 45 from from IN cord-016364-80l5mua2 295 46 recordings recording NNS cord-016364-80l5mua2 295 47 in in IN cord-016364-80l5mua2 295 48 cat cat NN cord-016364-80l5mua2 295 49 visual visual JJ cord-016364-80l5mua2 295 50 cortex cortex NN cord-016364-80l5mua2 295 51 Restoration Restoration NNP cord-016364-80l5mua2 295 52 of of IN cord-016364-80l5mua2 295 53 auditory auditory JJ cord-016364-80l5mua2 295 54 nerve nerve NN cord-016364-80l5mua2 295 55 synapses synapsis NNS cord-016364-80l5mua2 295 56 in in IN cord-016364-80l5mua2 295 57 cats cat NNS cord-016364-80l5mua2 295 58 by by IN cord-016364-80l5mua2 295 59 cochlear cochlear JJ cord-016364-80l5mua2 295 60 implants implant NNS cord-016364-80l5mua2 295 61 Generation generation NN cord-016364-80l5mua2 295 62 and and CC cord-016364-80l5mua2 295 63 characterization characterization NN cord-016364-80l5mua2 295 64 of of IN cord-016364-80l5mua2 295 65 a a DT cord-016364-80l5mua2 295 66 delta delta NN cord-016364-80l5mua2 295 67 F508 F508 NNP cord-016364-80l5mua2 295 68 cystic cystic JJ cord-016364-80l5mua2 295 69 fibrosis fibrosis NN cord-016364-80l5mua2 295 70 mouse mouse NN cord-016364-80l5mua2 295 71 model model NN cord-016364-80l5mua2 295 72 Effi Effi NNP cord-016364-80l5mua2 295 73 cient cient NN cord-016364-80l5mua2 295 74 killing killing NN cord-016364-80l5mua2 295 75 of of IN cord-016364-80l5mua2 295 76 inhaled inhale VBN cord-016364-80l5mua2 295 77 bacteria bacteria NNS cord-016364-80l5mua2 295 78 in in IN cord-016364-80l5mua2 295 79 DeltaF508 deltaf508 CD cord-016364-80l5mua2 295 80 mice mouse NNS cord-016364-80l5mua2 295 81 : : : cord-016364-80l5mua2 295 82 Role role NN cord-016364-80l5mua2 295 83 of of IN cord-016364-80l5mua2 295 84 airway airway NN cord-016364-80l5mua2 295 85 surface surface NN cord-016364-80l5mua2 295 86 liquid liquid NN cord-016364-80l5mua2 295 87 composition composition NN cord-016364-80l5mua2 295 88 Progress Progress NNP cord-016364-80l5mua2 295 89 toward toward IN cord-016364-80l5mua2 295 90 generating generate VBG cord-016364-80l5mua2 295 91 a a DT cord-016364-80l5mua2 295 92 ferret ferret JJ cord-016364-80l5mua2 295 93 model model NN cord-016364-80l5mua2 295 94 of of IN cord-016364-80l5mua2 295 95 cystic cystic JJ cord-016364-80l5mua2 295 96 fibrosis fibrosis NN cord-016364-80l5mua2 295 97 by by IN cord-016364-80l5mua2 295 98 somatic somatic JJ cord-016364-80l5mua2 295 99 cell cell NN cord-016364-80l5mua2 295 100 nuclear nuclear JJ cord-016364-80l5mua2 295 101 transfer transfer NN cord-016364-80l5mua2 295 102 Cloned clone VBN cord-016364-80l5mua2 295 103 ferrets ferret NNS cord-016364-80l5mua2 295 104 produced produce VBN cord-016364-80l5mua2 295 105 by by IN cord-016364-80l5mua2 295 106 somatic somatic JJ cord-016364-80l5mua2 295 107 cell cell NN cord-016364-80l5mua2 295 108 nuclear nuclear JJ cord-016364-80l5mua2 295 109 transfer transfer NN cord-016364-80l5mua2 295 110 Somatic somatic JJ cord-016364-80l5mua2 295 111 cell cell NN cord-016364-80l5mua2 295 112 nuclear nuclear JJ cord-016364-80l5mua2 295 113 transfer transfer NN cord-016364-80l5mua2 295 114 Production Production NNP cord-016364-80l5mua2 295 115 of of IN cord-016364-80l5mua2 295 116 alpha-1,3-galactosyltransferase alpha-1,3-galactosyltransferase JJ cord-016364-80l5mua2 295 117 knockout knockout NN cord-016364-80l5mua2 295 118 pigs pig NNS cord-016364-80l5mua2 295 119 by by IN cord-016364-80l5mua2 295 120 nuclear nuclear JJ cord-016364-80l5mua2 295 121 transfer transfer NN cord-016364-80l5mua2 295 122 cloning clone VBG cord-016364-80l5mua2 295 123 3-Galactosyltransferase 3-galactosyltransferase CD cord-016364-80l5mua2 295 124 - - HYPH cord-016364-80l5mua2 295 125 gene gene NN cord-016364-80l5mua2 295 126 knockout knockout NN cord-016364-80l5mua2 295 127 in in IN cord-016364-80l5mua2 295 128 cattle cattle NNS cord-016364-80l5mua2 295 129 using use VBG cord-016364-80l5mua2 295 130 a a DT cord-016364-80l5mua2 295 131 single single JJ cord-016364-80l5mua2 295 132 targeting targeting NN cord-016364-80l5mua2 295 133 vector vector NN cord-016364-80l5mua2 295 134 with with IN cord-016364-80l5mua2 295 135 loxP loxP NNP cord-016364-80l5mua2 295 136 sequences sequence NNS cord-016364-80l5mua2 295 137 and and CC cord-016364-80l5mua2 295 138 cre cre NN cord-016364-80l5mua2 295 139 - - HYPH cord-016364-80l5mua2 295 140 expressing express VBG cord-016364-80l5mua2 295 141 adenovirus adenovirus NN cord-016364-80l5mua2 295 142 A a DT cord-016364-80l5mua2 295 143 cat cat NN cord-016364-80l5mua2 295 144 cloned clone VBN cord-016364-80l5mua2 295 145 by by IN cord-016364-80l5mua2 295 146 nuclear nuclear JJ cord-016364-80l5mua2 295 147 transplantation transplantation NN cord-016364-80l5mua2 295 148 Birth birth NN cord-016364-80l5mua2 295 149 of of IN cord-016364-80l5mua2 295 150 African african JJ cord-016364-80l5mua2 295 151 wildcat wildcat NN cord-016364-80l5mua2 296 1 cloned clone VBN cord-016364-80l5mua2 296 2 kittens kitten NNS cord-016364-80l5mua2 296 3 born bear VBN cord-016364-80l5mua2 296 4 from from IN cord-016364-80l5mua2 296 5 domestic domestic JJ cord-016364-80l5mua2 296 6 cats cat NNS cord-016364-80l5mua2 296 7 Cats Cats NNPS cord-016364-80l5mua2 296 8 cloned clone VBN cord-016364-80l5mua2 296 9 from from IN cord-016364-80l5mua2 296 10 fetal fetal JJ cord-016364-80l5mua2 296 11 and and CC cord-016364-80l5mua2 296 12 adult adult NN cord-016364-80l5mua2 296 13 somatic somatic JJ cord-016364-80l5mua2 296 14 cells cell NNS cord-016364-80l5mua2 296 15 by by IN cord-016364-80l5mua2 296 16 nuclear nuclear JJ cord-016364-80l5mua2 296 17 transfer transfer NN cord-016364-80l5mua2 296 18 Nuclear nuclear JJ cord-016364-80l5mua2 296 19 transfer transfer NN cord-016364-80l5mua2 296 20 in in IN cord-016364-80l5mua2 296 21 cats cat NNS cord-016364-80l5mua2 296 22 and and CC cord-016364-80l5mua2 296 23 its -PRON- PRP$ cord-016364-80l5mua2 296 24 application application NN cord-016364-80l5mua2 296 25 Development Development NNP cord-016364-80l5mua2 296 26 of of IN cord-016364-80l5mua2 296 27 a a DT cord-016364-80l5mua2 296 28 feline feline JJ cord-016364-80l5mua2 296 29 whole whole JJ cord-016364-80l5mua2 296 30 - - HYPH cord-016364-80l5mua2 296 31 genome genome NN cord-016364-80l5mua2 296 32 radiation radiation NN cord-016364-80l5mua2 296 33 hybrid hybrid NN cord-016364-80l5mua2 296 34 panel panel NN cord-016364-80l5mua2 296 35 and and CC cord-016364-80l5mua2 296 36 comparative comparative JJ cord-016364-80l5mua2 296 37 mapping mapping NN cord-016364-80l5mua2 296 38 of of IN cord-016364-80l5mua2 296 39 human human JJ cord-016364-80l5mua2 296 40 chromosome chromosome NN cord-016364-80l5mua2 296 41 12 12 CD cord-016364-80l5mua2 296 42 and and CC cord-016364-80l5mua2 296 43 22 22 CD cord-016364-80l5mua2 296 44 loci locus NNS cord-016364-80l5mua2 297 1 The the DT cord-016364-80l5mua2 297 2 pattern pattern NN cord-016364-80l5mua2 297 3 of of IN cord-016364-80l5mua2 297 4 phylogenomic phylogenomic JJ cord-016364-80l5mua2 297 5 evolution evolution NN cord-016364-80l5mua2 297 6 of of IN cord-016364-80l5mua2 297 7 the the DT cord-016364-80l5mua2 297 8 Canidae Canidae NNP cord-016364-80l5mua2 297 9 Conservation Conservation NNP cord-016364-80l5mua2 297 10 of of IN cord-016364-80l5mua2 297 11 human human JJ cord-016364-80l5mua2 297 12 vs. vs. FW cord-016364-80l5mua2 297 13 feline feline JJ cord-016364-80l5mua2 297 14 genome genome NN cord-016364-80l5mua2 297 15 organization organization NN cord-016364-80l5mua2 297 16 revealed reveal VBN cord-016364-80l5mua2 297 17 by by IN cord-016364-80l5mua2 297 18 reciprocal reciprocal JJ cord-016364-80l5mua2 297 19 chromosome chromosome NN cord-016364-80l5mua2 297 20 painting paint VBG cord-016364-80l5mua2 297 21 The the DT cord-016364-80l5mua2 297 22 Coal Coal NNP cord-016364-80l5mua2 297 23 Colors color NNS cord-016364-80l5mua2 297 24 of of IN cord-016364-80l5mua2 297 25 Mice mouse NNS cord-016364-80l5mua2 297 26 : : : cord-016364-80l5mua2 297 27 A a DT cord-016364-80l5mua2 297 28 Model Model NNP cord-016364-80l5mua2 297 29 for for IN cord-016364-80l5mua2 297 30 Mammalian Mammalian NNP cord-016364-80l5mua2 297 31 Gene Gene NNP cord-016364-80l5mua2 297 32 Action Action NNP cord-016364-80l5mua2 297 33 and and CC cord-016364-80l5mua2 297 34 Interaction Interaction NNP cord-016364-80l5mua2 297 35 From from IN cord-016364-80l5mua2 297 36 white white JJ cord-016364-80l5mua2 297 37 spots spot NNS cord-016364-80l5mua2 297 38 to to TO cord-016364-80l5mua2 297 39 stem stem VB cord-016364-80l5mua2 297 40 cells cell NNS cord-016364-80l5mua2 297 41 : : : cord-016364-80l5mua2 297 42 The the DT cord-016364-80l5mua2 297 43 role role NN cord-016364-80l5mua2 297 44 of of IN cord-016364-80l5mua2 297 45 the the DT cord-016364-80l5mua2 297 46 Kit kit NN cord-016364-80l5mua2 297 47 receptor receptor NN cord-016364-80l5mua2 297 48 in in IN cord-016364-80l5mua2 297 49 mammalian mammalian JJ cord-016364-80l5mua2 297 50 development development NN cord-016364-80l5mua2 297 51 Molecular Molecular NNP cord-016364-80l5mua2 297 52 and and CC cord-016364-80l5mua2 297 53 developmental developmental JJ cord-016364-80l5mua2 297 54 genetics genetic NNS cord-016364-80l5mua2 297 55 of of IN cord-016364-80l5mua2 297 56 mouse mouse NN cord-016364-80l5mua2 297 57 coat coat NN cord-016364-80l5mua2 297 58 color color NN cord-016364-80l5mua2 297 59 Robinson Robinson NNP cord-016364-80l5mua2 297 60 's 's POS cord-016364-80l5mua2 297 61 Genetics Genetics NNP cord-016364-80l5mua2 297 62 for for IN cord-016364-80l5mua2 297 63 Cat Cat NNP cord-016364-80l5mua2 297 64 Breeders Breeders NNPS cord-016364-80l5mua2 297 65 and and CC cord-016364-80l5mua2 297 66 Veterinarians Veterinarians NNPS cord-016364-80l5mua2 297 67 Feline Feline NNP cord-016364-80l5mua2 297 68 Leukemia Leukemia NNP cord-016364-80l5mua2 297 69 Virus Virus NNP cord-016364-80l5mua2 297 70 Feline feline JJ cord-016364-80l5mua2 297 71 oncoretroviruses oncoretroviruse NNS cord-016364-80l5mua2 297 72 Plagues plague NNS cord-016364-80l5mua2 297 73 and and CC cord-016364-80l5mua2 297 74 adaptation adaptation NN cord-016364-80l5mua2 297 75 : : : cord-016364-80l5mua2 297 76 Lessons lesson NNS cord-016364-80l5mua2 297 77 from from IN cord-016364-80l5mua2 297 78 the the DT cord-016364-80l5mua2 297 79 Felidae Felidae NNP cord-016364-80l5mua2 297 80 models model NNS cord-016364-80l5mua2 297 81 for for IN cord-016364-80l5mua2 297 82 SARS SARS NNP cord-016364-80l5mua2 297 83 and and CC cord-016364-80l5mua2 297 84 AIDS AIDS NNP cord-016364-80l5mua2 298 1 The the DT cord-016364-80l5mua2 298 2 feline feline JJ cord-016364-80l5mua2 298 3 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 298 4 virus virus NN cord-016364-80l5mua2 298 5 FIV fiv NN cord-016364-80l5mua2 298 6 infection infection NN cord-016364-80l5mua2 298 7 of of IN cord-016364-80l5mua2 298 8 the the DT cord-016364-80l5mua2 298 9 domestic domestic JJ cord-016364-80l5mua2 298 10 cat cat NN cord-016364-80l5mua2 298 11 : : : cord-016364-80l5mua2 298 12 An an DT cord-016364-80l5mua2 298 13 animal animal NN cord-016364-80l5mua2 298 14 model model NN cord-016364-80l5mua2 298 15 for for IN cord-016364-80l5mua2 298 16 AIDS AIDS NNP cord-016364-80l5mua2 298 17 Toward toward IN cord-016364-80l5mua2 298 18 a a DT cord-016364-80l5mua2 298 19 detailed detailed JJ cord-016364-80l5mua2 298 20 characterization characterization NN cord-016364-80l5mua2 298 21 of of IN cord-016364-80l5mua2 298 22 feline feline JJ cord-016364-80l5mua2 298 23 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 298 24 virus virus NN cord-016364-80l5mua2 298 25 - - HYPH cord-016364-80l5mua2 298 26 specific specific JJ cord-016364-80l5mua2 298 27 T t NN cord-016364-80l5mua2 298 28 cell cell NN cord-016364-80l5mua2 298 29 immune immune JJ cord-016364-80l5mua2 298 30 responses response NNS cord-016364-80l5mua2 298 31 and and CC cord-016364-80l5mua2 298 32 mediated mediate VBN cord-016364-80l5mua2 298 33 immune immune JJ cord-016364-80l5mua2 298 34 disorders disorder NNS cord-016364-80l5mua2 298 35 Worldwide worldwide IN cord-016364-80l5mua2 298 36 prevalence prevalence NN cord-016364-80l5mua2 298 37 of of IN cord-016364-80l5mua2 298 38 lentivirus lentivirus NN cord-016364-80l5mua2 298 39 infection infection NN cord-016364-80l5mua2 298 40 in in IN cord-016364-80l5mua2 298 41 wild wild JJ cord-016364-80l5mua2 298 42 feline feline JJ cord-016364-80l5mua2 298 43 species specie NNS cord-016364-80l5mua2 298 44 : : : cord-016364-80l5mua2 298 45 Epidemiologic epidemiologic JJ cord-016364-80l5mua2 298 46 and and CC cord-016364-80l5mua2 298 47 phylogenetic phylogenetic JJ cord-016364-80l5mua2 298 48 aspects aspect NNS cord-016364-80l5mua2 299 1 A a DT cord-016364-80l5mua2 299 2 lion lion NN cord-016364-80l5mua2 299 3 lentivirus lentivirus NN cord-016364-80l5mua2 299 4 related relate VBN cord-016364-80l5mua2 299 5 to to IN cord-016364-80l5mua2 299 6 feline feline JJ cord-016364-80l5mua2 299 7 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 299 8 virus virus NN cord-016364-80l5mua2 299 9 : : : cord-016364-80l5mua2 299 10 Epidemiologic epidemiologic JJ cord-016364-80l5mua2 299 11 and and CC cord-016364-80l5mua2 299 12 phylogenetic phylogenetic JJ cord-016364-80l5mua2 299 13 aspects aspect NNS cord-016364-80l5mua2 300 1 Coadaptation Coadaptation NNP cord-016364-80l5mua2 300 2 and and CC cord-016364-80l5mua2 300 3 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 300 4 virus virus NN cord-016364-80l5mua2 300 5 : : : cord-016364-80l5mua2 301 1 Lessons lesson NNS cord-016364-80l5mua2 301 2 from from IN cord-016364-80l5mua2 301 3 the the DT cord-016364-80l5mua2 301 4 Felidae Felidae NNP cord-016364-80l5mua2 301 5 Patterns pattern NNS cord-016364-80l5mua2 301 6 of of IN cord-016364-80l5mua2 301 7 feline feline JJ cord-016364-80l5mua2 301 8 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 301 9 virus virus NN cord-016364-80l5mua2 301 10 multiple multiple JJ cord-016364-80l5mua2 301 11 infection infection NN cord-016364-80l5mua2 301 12 and and CC cord-016364-80l5mua2 301 13 genome genome NN cord-016364-80l5mua2 301 14 divergence divergence NN cord-016364-80l5mua2 301 15 in in IN cord-016364-80l5mua2 301 16 a a DT cord-016364-80l5mua2 301 17 free free RB cord-016364-80l5mua2 301 18 - - HYPH cord-016364-80l5mua2 301 19 ranging range VBG cord-016364-80l5mua2 301 20 population population NN cord-016364-80l5mua2 301 21 of of IN cord-016364-80l5mua2 301 22 African african JJ cord-016364-80l5mua2 301 23 lions lion NNS cord-016364-80l5mua2 301 24 Seroprevalence Seroprevalence NNP cord-016364-80l5mua2 301 25 and and CC cord-016364-80l5mua2 301 26 genomic genomic JJ cord-016364-80l5mua2 301 27 divergence divergence NN cord-016364-80l5mua2 301 28 of of IN cord-016364-80l5mua2 301 29 circulating circulate VBG cord-016364-80l5mua2 301 30 strains strain NNS cord-016364-80l5mua2 301 31 of of IN cord-016364-80l5mua2 301 32 feline feline JJ cord-016364-80l5mua2 301 33 immunodeficiency immunodeficiency NN cord-016364-80l5mua2 301 34 virus virus NN cord-016364-80l5mua2 301 35 among among IN cord-016364-80l5mua2 301 36 Felidae Felidae NNP cord-016364-80l5mua2 301 37 and and CC cord-016364-80l5mua2 301 38 Hyaenidae Hyaenidae NNP cord-016364-80l5mua2 301 39 species specie VBZ cord-016364-80l5mua2 301 40 Genomic Genomic NNP cord-016364-80l5mua2 301 41 prospecting prospect VBG cord-016364-80l5mua2 301 42 Feline feline JJ cord-016364-80l5mua2 301 43 lentiviruses lentiviruse NNS cord-016364-80l5mua2 301 44 demonstrate demonstrate VBP cord-016364-80l5mua2 301 45 differences difference NNS cord-016364-80l5mua2 301 46 in in IN cord-016364-80l5mua2 301 47 receptor receptor NN cord-016364-80l5mua2 301 48 repertoire repertoire NN cord-016364-80l5mua2 301 49 and and CC cord-016364-80l5mua2 301 50 envelope envelope NN cord-016364-80l5mua2 301 51 structural structural JJ cord-016364-80l5mua2 301 52 elements element NNS cord-016364-80l5mua2 302 1 SARS SARS NNP cord-016364-80l5mua2 302 2 - - HYPH cord-016364-80l5mua2 302 3 associated associate VBN cord-016364-80l5mua2 302 4 coronavirus coronavirus NN cord-016364-80l5mua2 302 5 Characterization characterization NN cord-016364-80l5mua2 302 6 of of IN cord-016364-80l5mua2 302 7 a a DT cord-016364-80l5mua2 302 8 novel novel JJ cord-016364-80l5mua2 302 9 coronavirus coronavirus NN cord-016364-80l5mua2 302 10 associated associate VBN cord-016364-80l5mua2 302 11 with with IN cord-016364-80l5mua2 302 12 severe severe JJ cord-016364-80l5mua2 302 13 acute acute JJ cord-016364-80l5mua2 302 14 respiratory respiratory JJ cord-016364-80l5mua2 302 15 syndrome syndrome NN cord-016364-80l5mua2 302 16 Unique unique JJ cord-016364-80l5mua2 302 17 and and CC cord-016364-80l5mua2 302 18 conserved conserve VBN cord-016364-80l5mua2 302 19 features feature NNS cord-016364-80l5mua2 302 20 of of IN cord-016364-80l5mua2 302 21 genome genome NN cord-016364-80l5mua2 302 22 and and CC cord-016364-80l5mua2 302 23 proteome proteome NN cord-016364-80l5mua2 302 24 of of IN cord-016364-80l5mua2 302 25 SARS SARS NNP cord-016364-80l5mua2 302 26 - - HYPH cord-016364-80l5mua2 302 27 coronavirus coronavirus NN cord-016364-80l5mua2 302 28 , , , cord-016364-80l5mua2 302 29 an an DT cord-016364-80l5mua2 302 30 early early JJ cord-016364-80l5mua2 302 31 split split NN cord-016364-80l5mua2 302 32 - - HYPH cord-016364-80l5mua2 302 33 off off NN cord-016364-80l5mua2 302 34 from from IN cord-016364-80l5mua2 302 35 the the DT cord-016364-80l5mua2 302 36 coronavirus coronavirus NN cord-016364-80l5mua2 302 37 group group NN cord-016364-80l5mua2 302 38 2 2 CD cord-016364-80l5mua2 302 39 lineage lineage NN cord-016364-80l5mua2 302 40 Coronavirus Coronavirus NNP cord-016364-80l5mua2 302 41 pathogenesis pathogenesis NN cord-016364-80l5mua2 302 42 and and CC cord-016364-80l5mua2 302 43 the the DT cord-016364-80l5mua2 302 44 emerging emerge VBG cord-016364-80l5mua2 302 45 pathogen pathogen NN cord-016364-80l5mua2 302 46 severe severe JJ cord-016364-80l5mua2 302 47 acute acute JJ cord-016364-80l5mua2 302 48 respiratory respiratory JJ cord-016364-80l5mua2 302 49 syndrome syndrome NN cord-016364-80l5mua2 302 50 coronavirus coronavirus NN cord-016364-80l5mua2 302 51 Animal Animal NNP cord-016364-80l5mua2 302 52 - - HYPH cord-016364-80l5mua2 302 53 to to IN cord-016364-80l5mua2 302 54 - - HYPH cord-016364-80l5mua2 302 55 human human JJ cord-016364-80l5mua2 302 56 SARS SARS NNP cord-016364-80l5mua2 302 57 - - HYPH cord-016364-80l5mua2 302 58 associated associate VBN cord-016364-80l5mua2 302 59 coronavirus coronavirus NN cord-016364-80l5mua2 302 60 transmission transmission NN cord-016364-80l5mua2 302 61 ? ? . cord-016364-80l5mua2 303 1 Civets civet NNS cord-016364-80l5mua2 303 2 are be VBP cord-016364-80l5mua2 303 3 equally equally RB cord-016364-80l5mua2 303 4 susceptible susceptible JJ cord-016364-80l5mua2 303 5 to to IN cord-016364-80l5mua2 303 6 experimental experimental JJ cord-016364-80l5mua2 303 7 infection infection NN cord-016364-80l5mua2 303 8 by by IN cord-016364-80l5mua2 303 9 two two CD cord-016364-80l5mua2 303 10 different different JJ cord-016364-80l5mua2 303 11 severe severe JJ cord-016364-80l5mua2 303 12 acute acute JJ cord-016364-80l5mua2 303 13 respiratory respiratory JJ cord-016364-80l5mua2 303 14 syndrome syndrome NN cord-016364-80l5mua2 303 15 coronavirus coronavirus NN cord-016364-80l5mua2 304 1 isolates isolate VBZ cord-016364-80l5mua2 304 2 Pet Pet NNP cord-016364-80l5mua2 304 3 theory theory NN cord-016364-80l5mua2 304 4 comes come VBZ cord-016364-80l5mua2 304 5 to to IN cord-016364-80l5mua2 304 6 the the DT cord-016364-80l5mua2 304 7 fore fore NN cord-016364-80l5mua2 304 8 in in IN cord-016364-80l5mua2 304 9 fight fight NN cord-016364-80l5mua2 304 10 against against IN cord-016364-80l5mua2 304 11 SARS SARS NNP cord-016364-80l5mua2 304 12 Virology Virology NNP cord-016364-80l5mua2 304 13 : : : cord-016364-80l5mua2 305 1 SARS SARS NNP cord-016364-80l5mua2 305 2 virus virus NN cord-016364-80l5mua2 305 3 infection infection NN cord-016364-80l5mua2 305 4 of of IN cord-016364-80l5mua2 305 5 cats cat NNS cord-016364-80l5mua2 305 6 and and CC cord-016364-80l5mua2 305 7 ferrets ferret NNS cord-016364-80l5mua2 306 1 The the DT cord-016364-80l5mua2 306 2 emergence emergence NN cord-016364-80l5mua2 306 3 and and CC cord-016364-80l5mua2 306 4 evolution evolution NN cord-016364-80l5mua2 306 5 of of IN cord-016364-80l5mua2 306 6 canine canine JJ cord-016364-80l5mua2 306 7 parvovirus parvovirus NN cord-016364-80l5mua2 306 8 - - : cord-016364-80l5mua2 306 9 an an DT cord-016364-80l5mua2 306 10 example example NN cord-016364-80l5mua2 306 11 of of IN cord-016364-80l5mua2 306 12 recent recent JJ cord-016364-80l5mua2 306 13 host host NN cord-016364-80l5mua2 306 14 range range NN cord-016364-80l5mua2 306 15 mutation mutation NN cord-016364-80l5mua2 307 1 A a DT cord-016364-80l5mua2 307 2 canine canine JJ cord-016364-80l5mua2 307 3 distemper distemper NN cord-016364-80l5mua2 307 4 virus virus NN cord-016364-80l5mua2 307 5 epidemic epidemic NN cord-016364-80l5mua2 307 6 in in IN cord-016364-80l5mua2 307 7 Serengeti Serengeti NNP cord-016364-80l5mua2 307 8 lions lion NNS cord-016364-80l5mua2 307 9 ( ( -LRB- cord-016364-80l5mua2 307 10 Panthera Panthera NNP cord-016364-80l5mua2 307 11 leo leo NNP cord-016364-80l5mua2 307 12 ) ) -RRB- cord-016364-80l5mua2 308 1 Plague Plague NNP cord-016364-80l5mua2 308 2 Time Time NNP cord-016364-80l5mua2 308 3 : : : cord-016364-80l5mua2 309 1 How how WRB cord-016364-80l5mua2 309 2 Stealth Stealth NNP cord-016364-80l5mua2 309 3 Infections Infections NNPS cord-016364-80l5mua2 309 4 Cause cause IN cord-016364-80l5mua2 309 5 Cancer Cancer NNP cord-016364-80l5mua2 309 6 , , , cord-016364-80l5mua2 309 7 Heart Heart NNP cord-016364-80l5mua2 309 8 Disease Disease NNP cord-016364-80l5mua2 309 9 , , , cord-016364-80l5mua2 309 10 and and CC cord-016364-80l5mua2 309 11 Other other JJ cord-016364-80l5mua2 309 12 Deadly Deadly NNP cord-016364-80l5mua2 309 13 Ailments Ailments NNPS cord-016364-80l5mua2 309 14 Germany Germany NNP cord-016364-80l5mua2 309 15 says say VBZ cord-016364-80l5mua2 309 16 people people NNS cord-016364-80l5mua2 309 17 in in IN cord-016364-80l5mua2 309 18 areas area NNS cord-016364-80l5mua2 309 19 with with IN cord-016364-80l5mua2 309 20 bird bird NN cord-016364-80l5mua2 309 21 flu flu NN cord-016364-80l5mua2 309 22 should should MD cord-016364-80l5mua2 309 23 keep keep VB cord-016364-80l5mua2 309 24 cats cat NNS cord-016364-80l5mua2 309 25 indoors indoors RB cord-016364-80l5mua2 309 26 H5N1 H5N1 NNP cord-016364-80l5mua2 309 27 virus virus NN cord-016364-80l5mua2 309 28 attachment attachment NN cord-016364-80l5mua2 309 29 to to TO cord-016364-80l5mua2 309 30 lower lower VB cord-016364-80l5mua2 309 31 respiratory respiratory JJ cord-016364-80l5mua2 309 32 tract tract NN cord-016364-80l5mua2 309 33 Infl Infl NNP cord-016364-80l5mua2 309 34 uenza uenza NNP cord-016364-80l5mua2 310 1 A a DT cord-016364-80l5mua2 310 2 virus virus NN cord-016364-80l5mua2 310 3 ( ( -LRB- cord-016364-80l5mua2 310 4 H5N1 H5N1 NNP cord-016364-80l5mua2 310 5 ) ) -RRB- cord-016364-80l5mua2 310 6 infection infection NN cord-016364-80l5mua2 310 7 in in IN cord-016364-80l5mua2 310 8 cats cat NNS cord-016364-80l5mua2 310 9 causes cause VBZ cord-016364-80l5mua2 310 10 systemic systemic JJ cord-016364-80l5mua2 310 11 disease disease NN cord-016364-80l5mua2 310 12 with with IN cord-016364-80l5mua2 310 13 potential potential JJ cord-016364-80l5mua2 310 14 novel novel JJ cord-016364-80l5mua2 310 15 routes route NNS cord-016364-80l5mua2 310 16 of of IN cord-016364-80l5mua2 310 17 virus virus NN cord-016364-80l5mua2 310 18 spread spread VBN cord-016364-80l5mua2 310 19 within within IN cord-016364-80l5mua2 310 20 and and CC cord-016364-80l5mua2 310 21 between between IN cord-016364-80l5mua2 310 22 hosts host NNS cord-016364-80l5mua2 310 23 Avian Avian NNP cord-016364-80l5mua2 310 24 H5N1 H5N1 NNP cord-016364-80l5mua2 310 25 infl infl NN cord-016364-80l5mua2 310 26 uenza uenza NN cord-016364-80l5mua2 310 27 in in IN cord-016364-80l5mua2 310 28 cats cat NNS cord-016364-80l5mua2 310 29 Feline feline JJ cord-016364-80l5mua2 310 30 friend friend NN cord-016364-80l5mua2 310 31 or or CC cord-016364-80l5mua2 310 32 potential potential JJ cord-016364-80l5mua2 310 33 foe foe NN cord-016364-80l5mua2 310 34 ? ? . cord-016364-80l5mua2 311 1 Comparative comparative JJ cord-016364-80l5mua2 311 2 gene gene NN cord-016364-80l5mua2 311 3 mapping mapping NN cord-016364-80l5mua2 311 4 in in IN cord-016364-80l5mua2 311 5 the the DT cord-016364-80l5mua2 311 6 domestic domestic JJ cord-016364-80l5mua2 311 7 cat cat NN cord-016364-80l5mua2 311 8 ( ( -LRB- cord-016364-80l5mua2 311 9 Felis Felis NNP cord-016364-80l5mua2 311 10 catus catus NN cord-016364-80l5mua2 311 11 ) ) -RRB- cord-016364-80l5mua2 312 1 ZOO zoo NN cord-016364-80l5mua2 312 2 - - HYPH cord-016364-80l5mua2 312 3 FISH fish NN cord-016364-80l5mua2 312 4 analysis analysis NN cord-016364-80l5mua2 313 1 : : : cord-016364-80l5mua2 313 2 Cat cat NN cord-016364-80l5mua2 313 3 and and CC cord-016364-80l5mua2 313 4 human human JJ cord-016364-80l5mua2 313 5 karyotypes karyotype NNS cord-016364-80l5mua2 313 6 closely closely RB cord-016364-80l5mua2 313 7 resemble resemble VBP cord-016364-80l5mua2 313 8 the the DT cord-016364-80l5mua2 313 9 putative putative JJ cord-016364-80l5mua2 313 10 ancestral ancestral JJ cord-016364-80l5mua2 313 11 mammalian mammalian JJ cord-016364-80l5mua2 313 12 karyotype karyotype NN cord-016364-80l5mua2 313 13 Patterns pattern NNS cord-016364-80l5mua2 313 14 of of IN cord-016364-80l5mua2 313 15 Y Y NNP cord-016364-80l5mua2 313 16 and and CC cord-016364-80l5mua2 313 17 X x NN cord-016364-80l5mua2 313 18 chromosome chromosome NN cord-016364-80l5mua2 313 19 DNA dna NN cord-016364-80l5mua2 313 20 sequence sequence NN cord-016364-80l5mua2 313 21 divergence divergence NN cord-016364-80l5mua2 313 22 during during IN cord-016364-80l5mua2 313 23 the the DT cord-016364-80l5mua2 313 24 Felidae Felidae NNP cord-016364-80l5mua2 313 25 radiation radiation NN cord-016364-80l5mua2 313 26 Phylogenetic Phylogenetic NNP cord-016364-80l5mua2 313 27 reconstruction reconstruction NN cord-016364-80l5mua2 313 28 of of IN cord-016364-80l5mua2 313 29 the the DT cord-016364-80l5mua2 313 30 Felidae Felidae NNP cord-016364-80l5mua2 313 31 using use VBG cord-016364-80l5mua2 313 32 16S 16S NNP cord-016364-80l5mua2 313 33 rRNA rRNA NNP cord-016364-80l5mua2 313 34 and and CC cord-016364-80l5mua2 313 35 NADH-5 NADH-5 NNPS cord-016364-80l5mua2 313 36 mitochondrial mitochondrial NN cord-016364-80l5mua2 313 37 genes gene NNS cord-016364-80l5mua2 313 38 Complete complete VBP cord-016364-80l5mua2 313 39 nucleotide nucleotide JJ cord-016364-80l5mua2 313 40 sequence sequence NN cord-016364-80l5mua2 313 41 of of IN cord-016364-80l5mua2 313 42 the the DT cord-016364-80l5mua2 313 43 domestic domestic JJ cord-016364-80l5mua2 313 44 cat cat NN cord-016364-80l5mua2 313 45 ( ( -LRB- cord-016364-80l5mua2 313 46 Felis Felis NNP cord-016364-80l5mua2 313 47 catus catus NN cord-016364-80l5mua2 313 48 ) ) -RRB- cord-016364-80l5mua2 313 49 mitochondrial mitochondrial NN cord-016364-80l5mua2 313 50 genome genome NN cord-016364-80l5mua2 313 51 and and CC cord-016364-80l5mua2 313 52 a a DT cord-016364-80l5mua2 313 53 transposed transpose VBN cord-016364-80l5mua2 313 54 mtDNA mtdna JJ cord-016364-80l5mua2 313 55 tandem tandem NN cord-016364-80l5mua2 313 56 repeat repeat NN cord-016364-80l5mua2 313 57 ( ( -LRB- cord-016364-80l5mua2 313 58 Numt Numt NNP cord-016364-80l5mua2 313 59 ) ) -RRB- cord-016364-80l5mua2 313 60 in in IN cord-016364-80l5mua2 313 61 the the DT cord-016364-80l5mua2 313 62 nuclear nuclear JJ cord-016364-80l5mua2 313 63 genome genome NN cord-016364-80l5mua2 313 64 Comparative Comparative NNP cord-016364-80l5mua2 313 65 genome genome NN cord-016364-80l5mua2 313 66 organization organization NN cord-016364-80l5mua2 313 67 of of IN cord-016364-80l5mua2 313 68 human human NN cord-016364-80l5mua2 313 69 , , , cord-016364-80l5mua2 313 70 murine murine JJ cord-016364-80l5mua2 313 71 , , , cord-016364-80l5mua2 313 72 and and CC cord-016364-80l5mua2 313 73 feline feline JJ cord-016364-80l5mua2 313 74 MHC MHC NNP cord-016364-80l5mua2 313 75 class class NN cord-016364-80l5mua2 313 76 II II NNP cord-016364-80l5mua2 313 77 region region NN