id	sid	tid	token	lemma	pos
cord-017527-ylng1us2	1	1	key	key	NN
cord-017527-ylng1us2	1	2	:	:	:
cord-017527-ylng1us2	2	1	cord-017527-ylng1us2	cord-017527-ylng1us2	NNPS
cord-017527-ylng1us2	3	1	authors	author	NNS
cord-017527-ylng1us2	3	2	:	:	:
cord-017527-ylng1us2	3	3	Herman	Herman	NNP
cord-017527-ylng1us2	3	4	,	,	,
cord-017527-ylng1us2	3	5	Philippe	Philippe	NNP
cord-017527-ylng1us2	3	6	;	;	:
cord-017527-ylng1us2	3	7	Pauwels	Pauwels	NNP
cord-017527-ylng1us2	3	8	,	,	,
cord-017527-ylng1us2	3	9	Katia	Katia	NNP
cord-017527-ylng1us2	3	10	title	title	NN
cord-017527-ylng1us2	3	11	:	:	:
cord-017527-ylng1us2	4	1	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	4	2	Recommendations	Recommendations	NNPS
cord-017527-ylng1us2	4	3	on	on	IN
cord-017527-ylng1us2	4	4	the	the	DT
cord-017527-ylng1us2	4	5	Handling	handling	NN
cord-017527-ylng1us2	4	6	of	of	IN
cord-017527-ylng1us2	4	7	Animal	Animal	NNP
cord-017527-ylng1us2	4	8	Cell	cell	NN
cord-017527-ylng1us2	4	9	Cultures	Cultures	NNPS
cord-017527-ylng1us2	4	10	date	date	NN
cord-017527-ylng1us2	4	11	:	:	:
cord-017527-ylng1us2	4	12	2014	2014	CD
cord-017527-ylng1us2	4	13	-	-	HYPH
cord-017527-ylng1us2	4	14	11	11	CD
cord-017527-ylng1us2	4	15	-	-	HYPH
cord-017527-ylng1us2	4	16	05	05	CD
cord-017527-ylng1us2	4	17	journal	journal	NN
cord-017527-ylng1us2	4	18	:	:	:
cord-017527-ylng1us2	4	19	Animal	Animal	NNP
cord-017527-ylng1us2	4	20	Cell	cell	NN
cord-017527-ylng1us2	4	21	Culture	culture	NN
cord-017527-ylng1us2	4	22	DOI	doi	NN
cord-017527-ylng1us2	4	23	:	:	:
cord-017527-ylng1us2	4	24	10.1007/978	10.1007/978	CD
cord-017527-ylng1us2	4	25	-	-	HYPH
cord-017527-ylng1us2	4	26	3	3	CD
cord-017527-ylng1us2	4	27	-	-	HYPH
cord-017527-ylng1us2	4	28	319	319	CD
cord-017527-ylng1us2	4	29	-	-	HYPH
cord-017527-ylng1us2	4	30	10320	10320	CD
cord-017527-ylng1us2	4	31	-	-	SYM
cord-017527-ylng1us2	4	32	4_22	4_22	CD
cord-017527-ylng1us2	4	33	sha	sha	NNP
cord-017527-ylng1us2	4	34	:	:	:
cord-017527-ylng1us2	5	1	710171d99a72ecec627a8bdea3a4d2a113b58819	710171d99a72ecec627a8bdea3a4d2a113b58819	CD
cord-017527-ylng1us2	5	2	doc_id	doc_id	CD
cord-017527-ylng1us2	5	3	:	:	:
cord-017527-ylng1us2	5	4	17527	17527	CD
cord-017527-ylng1us2	5	5	cord_uid	cord_uid	NNS
cord-017527-ylng1us2	5	6	:	:	:
cord-017527-ylng1us2	6	1	ylng1us2	ylng1us2	.
cord-017527-ylng1us2	7	1	The	the	DT
cord-017527-ylng1us2	7	2	first	first	JJ
cord-017527-ylng1us2	7	3	steps	step	NNS
cord-017527-ylng1us2	7	4	in	in	IN
cord-017527-ylng1us2	7	5	tissue	tissue	NN
cord-017527-ylng1us2	7	6	culture	culture	NN
cord-017527-ylng1us2	7	7	are	be	VBP
cord-017527-ylng1us2	7	8	dating	date	VBG
cord-017527-ylng1us2	7	9	back	back	RB
cord-017527-ylng1us2	7	10	to	to	IN
cord-017527-ylng1us2	7	11	the	the	DT
cord-017527-ylng1us2	7	12	beginning	beginning	NN
cord-017527-ylng1us2	7	13	of	of	IN
cord-017527-ylng1us2	7	14	the	the	DT
cord-017527-ylng1us2	7	15	nineteenth	nineteenth	JJ
cord-017527-ylng1us2	7	16	century	century	NN
cord-017527-ylng1us2	7	17	when	when	WRB
cord-017527-ylng1us2	7	18	biosafety	biosafety	NN
cord-017527-ylng1us2	7	19	measures	measure	NNS
cord-017527-ylng1us2	7	20	did	do	VBD
cord-017527-ylng1us2	7	21	not	not	RB
cord-017527-ylng1us2	7	22	yet	yet	RB
cord-017527-ylng1us2	7	23	exist	exist	VB
cord-017527-ylng1us2	7	24	.	.	.
cord-017527-ylng1us2	8	1	Later	later	RB
cord-017527-ylng1us2	8	2	on	on	RB
cord-017527-ylng1us2	8	3	,	,	,
cord-017527-ylng1us2	8	4	animal	animal	NN
cord-017527-ylng1us2	8	5	cell	cell	NN
cord-017527-ylng1us2	8	6	culture	culture	NN
cord-017527-ylng1us2	8	7	became	become	VBD
cord-017527-ylng1us2	8	8	essential	essential	JJ
cord-017527-ylng1us2	8	9	for	for	IN
cord-017527-ylng1us2	8	10	scientific	scientific	JJ
cord-017527-ylng1us2	8	11	research	research	NN
cord-017527-ylng1us2	8	12	,	,	,
cord-017527-ylng1us2	8	13	diagnosis	diagnosis	NN
cord-017527-ylng1us2	8	14	and	and	CC
cord-017527-ylng1us2	8	15	biotechnological	biotechnological	JJ
cord-017527-ylng1us2	8	16	activities	activity	NNS
cord-017527-ylng1us2	8	17	.	.	.
cord-017527-ylng1us2	9	1	Along	along	IN
cord-017527-ylng1us2	9	2	with	with	IN
cord-017527-ylng1us2	9	3	this	this	DT
cord-017527-ylng1us2	9	4	development	development	NN
cord-017527-ylng1us2	9	5	,	,	,
cord-017527-ylng1us2	9	6	biosafety	biosafety	NN
cord-017527-ylng1us2	9	7	concerns	concern	NNS
cord-017527-ylng1us2	9	8	have	have	VBP
cord-017527-ylng1us2	9	9	emerged	emerge	VBN
cord-017527-ylng1us2	9	10	pointing	point	VBG
cord-017527-ylng1us2	9	11	to	to	IN
cord-017527-ylng1us2	9	12	the	the	DT
cord-017527-ylng1us2	9	13	risks	risk	NNS
cord-017527-ylng1us2	9	14	for	for	IN
cord-017527-ylng1us2	9	15	human	human	JJ
cord-017527-ylng1us2	9	16	health	health	NN
cord-017527-ylng1us2	9	17	and	and	CC
cord-017527-ylng1us2	9	18	in	in	IN
cord-017527-ylng1us2	9	19	a	a	DT
cord-017527-ylng1us2	9	20	lesser	less	JJR
cord-017527-ylng1us2	9	21	extent	extent	NN
cord-017527-ylng1us2	9	22	for	for	IN
cord-017527-ylng1us2	9	23	the	the	DT
cord-017527-ylng1us2	9	24	environment	environment	NN
cord-017527-ylng1us2	9	25	associated	associate	VBN
cord-017527-ylng1us2	9	26	to	to	IN
cord-017527-ylng1us2	9	27	the	the	DT
cord-017527-ylng1us2	9	28	handling	handling	NN
cord-017527-ylng1us2	9	29	of	of	IN
cord-017527-ylng1us2	9	30	animal	animal	NN
cord-017527-ylng1us2	9	31	cell	cell	NN
cord-017527-ylng1us2	9	32	cultures	culture	NNS
cord-017527-ylng1us2	9	33	.	.	.
cord-017527-ylng1us2	10	1	The	the	DT
cord-017527-ylng1us2	10	2	management	management	NN
cord-017527-ylng1us2	10	3	of	of	IN
cord-017527-ylng1us2	10	4	these	these	DT
cord-017527-ylng1us2	10	5	risks	risk	NNS
cord-017527-ylng1us2	10	6	requires	require	VBZ
cord-017527-ylng1us2	10	7	a	a	DT
cord-017527-ylng1us2	10	8	thorough	thorough	JJ
cord-017527-ylng1us2	10	9	risk	risk	NN
cord-017527-ylng1us2	10	10	assessment	assessment	NN
cord-017527-ylng1us2	10	11	of	of	IN
cord-017527-ylng1us2	10	12	both	both	CC
cord-017527-ylng1us2	10	13	the	the	DT
cord-017527-ylng1us2	10	14	cell	cell	NN
cord-017527-ylng1us2	10	15	cultures	culture	NNS
cord-017527-ylng1us2	10	16	and	and	CC
cord-017527-ylng1us2	10	17	the	the	DT
cord-017527-ylng1us2	10	18	type	type	NN
cord-017527-ylng1us2	10	19	of	of	IN
cord-017527-ylng1us2	10	20	manipulation	manipulation	NN
cord-017527-ylng1us2	10	21	prior	prior	IN
cord-017527-ylng1us2	10	22	the	the	DT
cord-017527-ylng1us2	10	23	start	start	NN
cord-017527-ylng1us2	10	24	of	of	IN
cord-017527-ylng1us2	10	25	any	any	DT
cord-017527-ylng1us2	10	26	activity	activity	NN
cord-017527-ylng1us2	10	27	.	.	.
cord-017527-ylng1us2	11	1	It	-PRON-	PRP
cord-017527-ylng1us2	11	2	involves	involve	VBZ
cord-017527-ylng1us2	11	3	a	a	DT
cord-017527-ylng1us2	11	4	case	case	NN
cord-017527-ylng1us2	11	5	-	-	HYPH
cord-017527-ylng1us2	11	6	by	by	IN
cord-017527-ylng1us2	11	7	-	-	HYPH
cord-017527-ylng1us2	11	8	case	case	NN
cord-017527-ylng1us2	11	9	evaluation	evaluation	NN
cord-017527-ylng1us2	11	10	of	of	IN
cord-017527-ylng1us2	11	11	both	both	CC
cord-017527-ylng1us2	11	12	the	the	DT
cord-017527-ylng1us2	11	13	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	11	14	properties	property	NNS
cord-017527-ylng1us2	11	15	of	of	IN
cord-017527-ylng1us2	11	16	the	the	DT
cord-017527-ylng1us2	11	17	cell	cell	NN
cord-017527-ylng1us2	11	18	culture	culture	NN
cord-017527-ylng1us2	11	19	genetically	genetically	RB
cord-017527-ylng1us2	11	20	modified	modify	VBN
cord-017527-ylng1us2	11	21	or	or	CC
cord-017527-ylng1us2	11	22	not	not	RB
cord-017527-ylng1us2	11	23	and	and	CC
cord-017527-ylng1us2	11	24	the	the	DT
cord-017527-ylng1us2	11	25	probability	probability	NN
cord-017527-ylng1us2	11	26	that	that	IN
cord-017527-ylng1us2	11	27	it	-PRON-	PRP
cord-017527-ylng1us2	11	28	may	may	MD
cord-017527-ylng1us2	11	29	inadvertently	inadvertently	RB
cord-017527-ylng1us2	11	30	or	or	CC
cord-017527-ylng1us2	11	31	intentionally	intentionally	RB
cord-017527-ylng1us2	11	32	become	become	VB
cord-017527-ylng1us2	11	33	infected	infect	VBN
cord-017527-ylng1us2	11	34	with	with	IN
cord-017527-ylng1us2	11	35	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	11	36	micro	micro	NNS
cord-017527-ylng1us2	11	37	-	-	HYPH
cord-017527-ylng1us2	11	38	organisms	organism	NNS
cord-017527-ylng1us2	11	39	.	.	.
cord-017527-ylng1us2	12	1	The	the	DT
cord-017527-ylng1us2	12	2	latter	latter	JJ
cord-017527-ylng1us2	12	3	hazard	hazard	NN
cord-017527-ylng1us2	12	4	is	be	VBZ
cord-017527-ylng1us2	12	5	predominant	predominant	JJ
cord-017527-ylng1us2	12	6	when	when	WRB
cord-017527-ylng1us2	12	7	adventitious	adventitious	JJ
cord-017527-ylng1us2	12	8	contaminants	contaminant	NNS
cord-017527-ylng1us2	12	9	are	be	VBP
cord-017527-ylng1us2	12	10	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	12	11	or	or	CC
cord-017527-ylng1us2	12	12	have	have	VBP
cord-017527-ylng1us2	12	13	a	a	DT
cord-017527-ylng1us2	12	14	better	well	JJR
cord-017527-ylng1us2	12	15	capacity	capacity	NN
cord-017527-ylng1us2	12	16	to	to	TO
cord-017527-ylng1us2	12	17	persist	persist	VB
cord-017527-ylng1us2	12	18	in	in	IN
cord-017527-ylng1us2	12	19	unfavourable	unfavourable	JJ
cord-017527-ylng1us2	12	20	conditions	condition	NNS
cord-017527-ylng1us2	12	21	.	.	.
cord-017527-ylng1us2	13	1	Consequently	consequently	RB
cord-017527-ylng1us2	13	2	,	,	,
cord-017527-ylng1us2	13	3	most	most	JJS
cord-017527-ylng1us2	13	4	of	of	IN
cord-017527-ylng1us2	13	5	the	the	DT
cord-017527-ylng1us2	13	6	containment	containment	NN
cord-017527-ylng1us2	13	7	measures	measure	NNS
cord-017527-ylng1us2	13	8	primarily	primarily	RB
cord-017527-ylng1us2	13	9	aim	aim	VBP
cord-017527-ylng1us2	13	10	at	at	IN
cord-017527-ylng1us2	13	11	protecting	protect	VBG
cord-017527-ylng1us2	13	12	cells	cell	NNS
cord-017527-ylng1us2	13	13	from	from	IN
cord-017527-ylng1us2	13	14	adventitious	adventitious	JJ
cord-017527-ylng1us2	13	15	contamination	contamination	NN
cord-017527-ylng1us2	13	16	.	.	.
cord-017527-ylng1us2	14	1	Cell	cell	NN
cord-017527-ylng1us2	14	2	cultures	culture	NNS
cord-017527-ylng1us2	14	3	known	know	VBN
cord-017527-ylng1us2	14	4	to	to	TO
cord-017527-ylng1us2	14	5	harbour	harbour	VB
cord-017527-ylng1us2	14	6	an	an	DT
cord-017527-ylng1us2	14	7	infectious	infectious	JJ
cord-017527-ylng1us2	14	8	etiologic	etiologic	JJ
cord-017527-ylng1us2	14	9	agent	agent	NN
cord-017527-ylng1us2	14	10	should	should	MD
cord-017527-ylng1us2	14	11	be	be	VB
cord-017527-ylng1us2	14	12	manipulated	manipulate	VBN
cord-017527-ylng1us2	14	13	in	in	IN
cord-017527-ylng1us2	14	14	compliance	compliance	NN
cord-017527-ylng1us2	14	15	with	with	IN
cord-017527-ylng1us2	14	16	containment	containment	NN
cord-017527-ylng1us2	14	17	measures	measure	NNS
cord-017527-ylng1us2	14	18	recommended	recommend	VBN
cord-017527-ylng1us2	14	19	for	for	IN
cord-017527-ylng1us2	14	20	the	the	DT
cord-017527-ylng1us2	14	21	etiologic	etiologic	NNP
cord-017527-ylng1us2	14	22	agent	agent	NN
cord-017527-ylng1us2	14	23	itself	-PRON-	PRP
cord-017527-ylng1us2	14	24	.	.	.
cord-017527-ylng1us2	15	1	The	the	DT
cord-017527-ylng1us2	15	2	manipulation	manipulation	NN
cord-017527-ylng1us2	15	3	of	of	IN
cord-017527-ylng1us2	15	4	cell	cell	NN
cord-017527-ylng1us2	15	5	cultures	culture	NNS
cord-017527-ylng1us2	15	6	from	from	IN
cord-017527-ylng1us2	15	7	human	human	JJ
cord-017527-ylng1us2	15	8	or	or	CC
cord-017527-ylng1us2	15	9	primate	primate	JJ
cord-017527-ylng1us2	15	10	origin	origin	NN
cord-017527-ylng1us2	15	11	necessitates	necessitate	VBZ
cord-017527-ylng1us2	15	12	the	the	DT
cord-017527-ylng1us2	15	13	use	use	NN
cord-017527-ylng1us2	15	14	of	of	IN
cord-017527-ylng1us2	15	15	a	a	DT
cord-017527-ylng1us2	15	16	type	type	NN
cord-017527-ylng1us2	15	17	II	II	NNP
cord-017527-ylng1us2	15	18	biosafety	biosafety	NN
cord-017527-ylng1us2	15	19	cabinet	cabinet	NN
cord-017527-ylng1us2	15	20	.	.	.
cord-017527-ylng1us2	16	1	The	the	DT
cord-017527-ylng1us2	16	2	scope	scope	NN
cord-017527-ylng1us2	16	3	of	of	IN
cord-017527-ylng1us2	16	4	this	this	DT
cord-017527-ylng1us2	16	5	chapter	chapter	NN
cord-017527-ylng1us2	16	6	is	be	VBZ
cord-017527-ylng1us2	16	7	to	to	TO
cord-017527-ylng1us2	16	8	highlight	highlight	VB
cord-017527-ylng1us2	16	9	aspects	aspect	NNS
cord-017527-ylng1us2	16	10	relevant	relevant	JJ
cord-017527-ylng1us2	16	11	for	for	IN
cord-017527-ylng1us2	16	12	the	the	DT
cord-017527-ylng1us2	16	13	risk	risk	NN
cord-017527-ylng1us2	16	14	assessment	assessment	NN
cord-017527-ylng1us2	16	15	and	and	CC
cord-017527-ylng1us2	16	16	to	to	TO
cord-017527-ylng1us2	16	17	summarize	summarize	VB
cord-017527-ylng1us2	16	18	the	the	DT
cord-017527-ylng1us2	16	19	main	main	JJ
cord-017527-ylng1us2	16	20	biosafety	biosafety	NN
cord-017527-ylng1us2	16	21	recommendations	recommendation	NNS
cord-017527-ylng1us2	16	22	and	and	CC
cord-017527-ylng1us2	16	23	the	the	DT
cord-017527-ylng1us2	16	24	recent	recent	JJ
cord-017527-ylng1us2	16	25	technological	technological	JJ
cord-017527-ylng1us2	16	26	advances	advance	NNS
cord-017527-ylng1us2	16	27	allowing	allow	VBG
cord-017527-ylng1us2	16	28	a	a	DT
cord-017527-ylng1us2	16	29	mitigation	mitigation	NN
cord-017527-ylng1us2	16	30	of	of	IN
cord-017527-ylng1us2	16	31	the	the	DT
cord-017527-ylng1us2	16	32	risk	risk	NN
cord-017527-ylng1us2	16	33	for	for	IN
cord-017527-ylng1us2	16	34	the	the	DT
cord-017527-ylng1us2	16	35	handling	handling	NN
cord-017527-ylng1us2	16	36	of	of	IN
cord-017527-ylng1us2	16	37	animal	animal	NN
cord-017527-ylng1us2	16	38	cell	cell	NN
cord-017527-ylng1us2	16	39	cultures	culture	NNS
cord-017527-ylng1us2	16	40	.	.	.
cord-017527-ylng1us2	17	1	Specified	specify	VBN
cord-017527-ylng1us2	17	2	-	-	HYPH
cord-017527-ylng1us2	17	3	pathogen	pathogen	NN
cord-017527-ylng1us2	17	4	-	-	HYPH
cord-017527-ylng1us2	17	5	free	free	JJ
cord-017527-ylng1us2	17	6	TSE	TSE	NNP
cord-017527-ylng1us2	17	7	Transmissible	transmissible	JJ
cord-017527-ylng1us2	17	8	spongiform	spongiform	JJ
cord-017527-ylng1us2	17	9	encephalopathies	encephalopathy	NNS
cord-017527-ylng1us2	17	10	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	17	11	is	be	VBZ
cord-017527-ylng1us2	17	12	a	a	DT
cord-017527-ylng1us2	17	13	concept	concept	NN
cord-017527-ylng1us2	17	14	that	that	WDT
cord-017527-ylng1us2	17	15	refers	refer	VBZ
cord-017527-ylng1us2	17	16	to	to	IN
cord-017527-ylng1us2	17	17	the	the	DT
cord-017527-ylng1us2	17	18	need	need	NN
cord-017527-ylng1us2	17	19	to	to	TO
cord-017527-ylng1us2	17	20	protect	protect	VB
cord-017527-ylng1us2	17	21	human	human	JJ
cord-017527-ylng1us2	17	22	health	health	NN
cord-017527-ylng1us2	17	23	and	and	CC
cord-017527-ylng1us2	17	24	the	the	DT
cord-017527-ylng1us2	17	25	environment	environment	NN
cord-017527-ylng1us2	17	26	from	from	IN
cord-017527-ylng1us2	17	27	the	the	DT
cord-017527-ylng1us2	17	28	possible	possible	JJ
cord-017527-ylng1us2	17	29	adverse	adverse	JJ
cord-017527-ylng1us2	17	30	effects	effect	NNS
cord-017527-ylng1us2	17	31	of	of	IN
cord-017527-ylng1us2	17	32	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	17	33	and/or	and/or	CC
cord-017527-ylng1us2	17	34	genetically	genetically	RB
cord-017527-ylng1us2	17	35	modified	modify	VBN
cord-017527-ylng1us2	17	36	organisms	organism	NNS
cord-017527-ylng1us2	17	37	and	and	CC
cord-017527-ylng1us2	17	38	micro	micro	NNS
cord-017527-ylng1us2	17	39	-	-	NNS
cord-017527-ylng1us2	17	40	organisms	organism	NNS
cord-017527-ylng1us2	17	41	used	use	VBN
cord-017527-ylng1us2	17	42	in	in	IN
cord-017527-ylng1us2	17	43	basic	basic	JJ
cord-017527-ylng1us2	17	44	research	research	NN
cord-017527-ylng1us2	17	45	,	,	,
cord-017527-ylng1us2	17	46	research	research	NN
cord-017527-ylng1us2	17	47	and	and	CC
cord-017527-ylng1us2	17	48	development	development	NN
cord-017527-ylng1us2	17	49	(	(	-LRB-
cord-017527-ylng1us2	17	50	R&D	r&d	NN
cord-017527-ylng1us2	17	51	)	)	-RRB-
cord-017527-ylng1us2	17	52	and	and	CC
cord-017527-ylng1us2	17	53	modern	modern	JJ
cord-017527-ylng1us2	17	54	biotechnology	biotechnology	NN
cord-017527-ylng1us2	17	55	.	.	.
cord-017527-ylng1us2	18	1	To	to	IN
cord-017527-ylng1us2	18	2	this	this	DT
cord-017527-ylng1us2	18	3	end	end	NN
cord-017527-ylng1us2	18	4	,	,	,
cord-017527-ylng1us2	18	5	a	a	DT
cord-017527-ylng1us2	18	6	case	case	NN
cord-017527-ylng1us2	18	7	-	-	HYPH
cord-017527-ylng1us2	18	8	by	by	IN
cord-017527-ylng1us2	18	9	-	-	HYPH
cord-017527-ylng1us2	18	10	case	case	NN
cord-017527-ylng1us2	18	11	risk	risk	NN
cord-017527-ylng1us2	18	12	assessment	assessment	NN
cord-017527-ylng1us2	18	13	is	be	VBZ
cord-017527-ylng1us2	18	14	conducted	conduct	VBN
cord-017527-ylng1us2	18	15	which	which	WDT
cord-017527-ylng1us2	18	16	consists	consist	VBZ
cord-017527-ylng1us2	18	17	in	in	IN
cord-017527-ylng1us2	18	18	the	the	DT
cord-017527-ylng1us2	18	19	identification	identification	NN
cord-017527-ylng1us2	18	20	and	and	CC
cord-017527-ylng1us2	18	21	characterisation	characterisation	NN
cord-017527-ylng1us2	18	22	of	of	IN
cord-017527-ylng1us2	18	23	potential	potential	JJ
cord-017527-ylng1us2	18	24	effects	effect	NNS
cord-017527-ylng1us2	18	25	,	,	,
cord-017527-ylng1us2	18	26	which	which	WDT
cord-017527-ylng1us2	18	27	may	may	MD
cord-017527-ylng1us2	18	28	be	be	VB
cord-017527-ylng1us2	18	29	intended	intend	VBN
cord-017527-ylng1us2	18	30	or	or	CC
cord-017527-ylng1us2	18	31	unintended	unintended	JJ
cord-017527-ylng1us2	18	32	,	,	,
cord-017527-ylng1us2	18	33	together	together	RB
cord-017527-ylng1us2	18	34	with	with	IN
cord-017527-ylng1us2	18	35	an	an	DT
cord-017527-ylng1us2	18	36	assessment	assessment	NN
cord-017527-ylng1us2	18	37	of	of	IN
cord-017527-ylng1us2	18	38	the	the	DT
cord-017527-ylng1us2	18	39	likelihood	likelihood	NN
cord-017527-ylng1us2	18	40	and	and	CC
cord-017527-ylng1us2	18	41	consequences	consequence	NNS
cord-017527-ylng1us2	18	42	should	should	MD
cord-017527-ylng1us2	18	43	any	any	DT
cord-017527-ylng1us2	18	44	effect	effect	NN
cord-017527-ylng1us2	18	45	occur	occur	VB
cord-017527-ylng1us2	18	46	.	.	.
cord-017527-ylng1us2	19	1	Depending	depend	VBG
cord-017527-ylng1us2	19	2	on	on	IN
cord-017527-ylng1us2	19	3	the	the	DT
cord-017527-ylng1us2	19	4	risks	risk	NNS
cord-017527-ylng1us2	19	5	identified	identify	VBN
cord-017527-ylng1us2	19	6	,	,	,
cord-017527-ylng1us2	19	7	risk	risk	NN
cord-017527-ylng1us2	19	8	management	management	NN
cord-017527-ylng1us2	19	9	measures	measure	NNS
cord-017527-ylng1us2	19	10	can	can	MD
cord-017527-ylng1us2	19	11	be	be	VB
cord-017527-ylng1us2	19	12	proposed	propose	VBN
cord-017527-ylng1us2	19	13	.	.	.
cord-017527-ylng1us2	20	1	The	the	DT
cord-017527-ylng1us2	20	2	use	use	NN
cord-017527-ylng1us2	20	3	of	of	IN
cord-017527-ylng1us2	20	4	cell	cell	NN
cord-017527-ylng1us2	20	5	cultures	culture	NNS
cord-017527-ylng1us2	20	6	may	may	MD
cord-017527-ylng1us2	20	7	fall	fall	VB
cord-017527-ylng1us2	20	8	within	within	IN
cord-017527-ylng1us2	20	9	the	the	DT
cord-017527-ylng1us2	20	10	scope	scope	NN
cord-017527-ylng1us2	20	11	of	of	IN
cord-017527-ylng1us2	20	12	one	one	CD
cord-017527-ylng1us2	20	13	or	or	CC
cord-017527-ylng1us2	20	14	several	several	JJ
cord-017527-ylng1us2	20	15	regulatory	regulatory	JJ
cord-017527-ylng1us2	20	16	provisions	provision	NNS
cord-017527-ylng1us2	20	17	which	which	WDT
cord-017527-ylng1us2	20	18	consider	consider	VBP
cord-017527-ylng1us2	20	19	an	an	DT
cord-017527-ylng1us2	20	20	assessment	assessment	NN
cord-017527-ylng1us2	20	21	of	of	IN
cord-017527-ylng1us2	20	22	biological	biological	JJ
cord-017527-ylng1us2	20	23	risks	risk	NNS
cord-017527-ylng1us2	20	24	.	.	.
cord-017527-ylng1us2	21	1	For	for	IN
cord-017527-ylng1us2	21	2	example	example	NN
cord-017527-ylng1us2	21	3	in	in	IN
cord-017527-ylng1us2	21	4	Europe	Europe	NNP
cord-017527-ylng1us2	21	5	,	,	,
cord-017527-ylng1us2	21	6	tissue	tissue	NN
cord-017527-ylng1us2	21	7	culture	culture	NN
cord-017527-ylng1us2	21	8	work	work	NN
cord-017527-ylng1us2	21	9	will	will	MD
cord-017527-ylng1us2	21	10	in	in	IN
cord-017527-ylng1us2	21	11	many	many	JJ
cord-017527-ylng1us2	21	12	cases	case	NNS
cord-017527-ylng1us2	21	13	involve	involve	VBP
cord-017527-ylng1us2	21	14	the	the	DT
cord-017527-ylng1us2	21	15	use	use	NN
cord-017527-ylng1us2	21	16	of	of	IN
cord-017527-ylng1us2	21	17	genetically	genetically	RB
cord-017527-ylng1us2	21	18	modified	modify	VBN
cord-017527-ylng1us2	21	19	cell	cell	NN
cord-017527-ylng1us2	21	20	lines	line	NNS
cord-017527-ylng1us2	21	21	as	as	RB
cord-017527-ylng1us2	21	22	well	well	RB
cord-017527-ylng1us2	21	23	,	,	,
cord-017527-ylng1us2	21	24	in	in	IN
cord-017527-ylng1us2	21	25	which	which	WDT
cord-017527-ylng1us2	21	26	case	case	NN
cord-017527-ylng1us2	21	27	a	a	DT
cord-017527-ylng1us2	21	28	risk	risk	NN
cord-017527-ylng1us2	21	29	assessment	assessment	NN
cord-017527-ylng1us2	21	30	should	should	MD
cord-017527-ylng1us2	21	31	be	be	VB
cord-017527-ylng1us2	21	32	made	make	VBN
cord-017527-ylng1us2	21	33	in	in	IN
cord-017527-ylng1us2	21	34	accordance	accordance	NN
cord-017527-ylng1us2	21	35	with	with	IN
cord-017527-ylng1us2	21	36	the	the	DT
cord-017527-ylng1us2	21	37	provisions	provision	NNS
cord-017527-ylng1us2	21	38	of	of	IN
cord-017527-ylng1us2	21	39	the	the	DT
cord-017527-ylng1us2	21	40	Directive	Directive	NNP
cord-017527-ylng1us2	21	41	2009/41	2009/41	CD
cord-017527-ylng1us2	21	42	/	/	SYM
cord-017527-ylng1us2	21	43	EC	EC	NNP
cord-017527-ylng1us2	21	44	related	relate	VBD
cord-017527-ylng1us2	21	45	to	to	IN
cord-017527-ylng1us2	21	46	the	the	DT
cord-017527-ylng1us2	21	47	contained	contain	VBN
cord-017527-ylng1us2	21	48	use	use	NN
cord-017527-ylng1us2	21	49	of	of	IN
cord-017527-ylng1us2	21	50	genetically	genetically	RB
cord-017527-ylng1us2	21	51	modified	modify	VBN
cord-017527-ylng1us2	21	52	micro	micro	NNS
cord-017527-ylng1us2	21	53	-	-	HYPH
cord-017527-ylng1us2	21	54	organisms	organism	NNS
cord-017527-ylng1us2	21	55	(	(	-LRB-
cord-017527-ylng1us2	21	56	European	European	NNP
cord-017527-ylng1us2	21	57	Commission	Commission	NNP
cord-017527-ylng1us2	21	58	2009	2009	CD
cord-017527-ylng1us2	21	59	)	)	-RRB-
cord-017527-ylng1us2	21	60	.	.	.
cord-017527-ylng1us2	22	1	Cell	cell	NN
cord-017527-ylng1us2	22	2	culturing	culturing	NN
cord-017527-ylng1us2	22	3	activities	activity	NNS
cord-017527-ylng1us2	22	4	aiming	aim	VBG
cord-017527-ylng1us2	22	5	at	at	IN
cord-017527-ylng1us2	22	6	manufacturing	manufacture	VBG
cord-017527-ylng1us2	22	7	biopharmaceuticals	biopharmaceutical	NNS
cord-017527-ylng1us2	22	8	are	be	VBP
cord-017527-ylng1us2	22	9	covered	cover	VBN
cord-017527-ylng1us2	22	10	by	by	IN
cord-017527-ylng1us2	22	11	the	the	DT
cord-017527-ylng1us2	22	12	Regulation	Regulation	NNP
cord-017527-ylng1us2	22	13	(	(	-LRB-
cord-017527-ylng1us2	22	14	EC	EC	NNP
cord-017527-ylng1us2	22	15	)	)	-RRB-
cord-017527-ylng1us2	23	1	No	no	DT
cord-017527-ylng1us2	23	2	726/2004	726/2004	NNP
cord-017527-ylng1us2	23	3	and	and	CC
cord-017527-ylng1us2	23	4	its	-PRON-	PRP$
cord-017527-ylng1us2	23	5	amending	amend	VBG
cord-017527-ylng1us2	23	6	acts	act	NNS
cord-017527-ylng1us2	23	7	laying	lay	VBG
cord-017527-ylng1us2	23	8	down	down	RP
cord-017527-ylng1us2	23	9	procedures	procedure	NNS
cord-017527-ylng1us2	23	10	for	for	IN
cord-017527-ylng1us2	23	11	the	the	DT
cord-017527-ylng1us2	23	12	authorisation	authorisation	NN
cord-017527-ylng1us2	23	13	and	and	CC
cord-017527-ylng1us2	23	14	supervision	supervision	NN
cord-017527-ylng1us2	23	15	of	of	IN
cord-017527-ylng1us2	23	16	medicinal	medicinal	JJ
cord-017527-ylng1us2	23	17	products	product	NNS
cord-017527-ylng1us2	23	18	for	for	IN
cord-017527-ylng1us2	23	19	human	human	JJ
cord-017527-ylng1us2	23	20	and	and	CC
cord-017527-ylng1us2	23	21	veterinary	veterinary	JJ
cord-017527-ylng1us2	23	22	use	use	NN
cord-017527-ylng1us2	23	23	(	(	-LRB-
cord-017527-ylng1us2	23	24	European	European	NNP
cord-017527-ylng1us2	23	25	Commission	Commission	NNP
cord-017527-ylng1us2	23	26	2004a	2004a	CD
cord-017527-ylng1us2	23	27	)	)	-RRB-
cord-017527-ylng1us2	23	28	,	,	,
cord-017527-ylng1us2	23	29	whereas	whereas	IN
cord-017527-ylng1us2	23	30	activities	activity	NNS
cord-017527-ylng1us2	23	31	that	that	WDT
cord-017527-ylng1us2	23	32	involve	involve	VBP
cord-017527-ylng1us2	23	33	the	the	DT
cord-017527-ylng1us2	23	34	use	use	NN
cord-017527-ylng1us2	23	35	of	of	IN
cord-017527-ylng1us2	23	36	human	human	JJ
cord-017527-ylng1us2	23	37	cells	cell	NNS
cord-017527-ylng1us2	23	38	and	and	CC
cord-017527-ylng1us2	23	39	tissues	tissue	NNS
cord-017527-ylng1us2	23	40	for	for	IN
cord-017527-ylng1us2	23	41	application	application	NN
cord-017527-ylng1us2	23	42	to	to	IN
cord-017527-ylng1us2	23	43	the	the	DT
cord-017527-ylng1us2	23	44	human	human	JJ
cord-017527-ylng1us2	23	45	body	body	NN
cord-017527-ylng1us2	23	46	falls	fall	VBZ
cord-017527-ylng1us2	23	47	within	within	IN
cord-017527-ylng1us2	23	48	the	the	DT
cord-017527-ylng1us2	23	49	scope	scope	NN
cord-017527-ylng1us2	23	50	of	of	IN
cord-017527-ylng1us2	23	51	the	the	DT
cord-017527-ylng1us2	23	52	Directive	Directive	NNP
cord-017527-ylng1us2	23	53	2004/23	2004/23	CD
cord-017527-ylng1us2	23	54	/	/	SYM
cord-017527-ylng1us2	23	55	EC	EC	NNP
cord-017527-ylng1us2	23	56	and	and	CC
cord-017527-ylng1us2	23	57	its	-PRON-	PRP$
cord-017527-ylng1us2	23	58	amending	amending	NN
cord-017527-ylng1us2	23	59	acts	act	NNS
cord-017527-ylng1us2	23	60	(	(	-LRB-
cord-017527-ylng1us2	23	61	European	European	NNP
cord-017527-ylng1us2	23	62	Commission	Commission	NNP
cord-017527-ylng1us2	23	63	2004b	2004b	CD
cord-017527-ylng1us2	23	64	)	)	-RRB-
cord-017527-ylng1us2	23	65	.	.	.
cord-017527-ylng1us2	24	1	The	the	DT
cord-017527-ylng1us2	24	2	manipulation	manipulation	NN
cord-017527-ylng1us2	24	3	of	of	IN
cord-017527-ylng1us2	24	4	animal	animal	NN
cord-017527-ylng1us2	24	5	cell	cell	NN
cord-017527-ylng1us2	24	6	cultures	culture	NNS
cord-017527-ylng1us2	24	7	also	also	RB
cord-017527-ylng1us2	24	8	exposes	expose	VBZ
cord-017527-ylng1us2	24	9	the	the	DT
cord-017527-ylng1us2	24	10	worker	worker	NN
cord-017527-ylng1us2	24	11	to	to	IN
cord-017527-ylng1us2	24	12	potential	potential	JJ
cord-017527-ylng1us2	24	13	biological	biological	JJ
cord-017527-ylng1us2	24	14	risks	risk	NNS
cord-017527-ylng1us2	24	15	which	which	WDT
cord-017527-ylng1us2	24	16	are	be	VBP
cord-017527-ylng1us2	24	17	considered	consider	VBN
cord-017527-ylng1us2	24	18	under	under	IN
cord-017527-ylng1us2	24	19	the	the	DT
cord-017527-ylng1us2	24	20	provision	provision	NN
cord-017527-ylng1us2	24	21	of	of	IN
cord-017527-ylng1us2	24	22	the	the	DT
cord-017527-ylng1us2	24	23	European	European	NNP
cord-017527-ylng1us2	24	24	Directive	Directive	NNP
cord-017527-ylng1us2	25	1	2000/54/	2000/54/	CD
cord-017527-ylng1us2	25	2	EC	EC	NNP
cord-017527-ylng1us2	25	3	(	(	-LRB-
cord-017527-ylng1us2	25	4	European	European	NNP
cord-017527-ylng1us2	25	5	Commission	Commission	NNP
cord-017527-ylng1us2	25	6	2000	2000	CD
cord-017527-ylng1us2	25	7	)	)	-RRB-
cord-017527-ylng1us2	25	8	.	.	.
cord-017527-ylng1us2	26	1	It	-PRON-	PRP
cord-017527-ylng1us2	26	2	should	should	MD
cord-017527-ylng1us2	26	3	be	be	VB
cord-017527-ylng1us2	26	4	pointed	point	VBN
cord-017527-ylng1us2	26	5	out	out	RP
cord-017527-ylng1us2	26	6	that	that	IN
cord-017527-ylng1us2	26	7	guidelines	guideline	NNS
cord-017527-ylng1us2	26	8	aiming	aim	VBG
cord-017527-ylng1us2	26	9	at	at	IN
cord-017527-ylng1us2	26	10	mitigating	mitigate	VBG
cord-017527-ylng1us2	26	11	the	the	DT
cord-017527-ylng1us2	26	12	biological	biological	JJ
cord-017527-ylng1us2	26	13	risks	risk	NNS
cord-017527-ylng1us2	26	14	for	for	IN
cord-017527-ylng1us2	26	15	the	the	DT
cord-017527-ylng1us2	26	16	laboratory	laboratory	NN
cord-017527-ylng1us2	26	17	workers	worker	NNS
cord-017527-ylng1us2	26	18	,	,	,
cord-017527-ylng1us2	26	19	public	public	JJ
cord-017527-ylng1us2	26	20	health	health	NN
cord-017527-ylng1us2	26	21	and	and	CC
cord-017527-ylng1us2	26	22	the	the	DT
cord-017527-ylng1us2	26	23	environment	environment	NN
cord-017527-ylng1us2	26	24	have	have	VBP
cord-017527-ylng1us2	26	25	been	be	VBN
cord-017527-ylng1us2	26	26	issued	issue	VBN
cord-017527-ylng1us2	26	27	by	by	IN
cord-017527-ylng1us2	26	28	some	some	DT
cord-017527-ylng1us2	26	29	scientific	scientific	JJ
cord-017527-ylng1us2	26	30	advisory	advisory	JJ
cord-017527-ylng1us2	26	31	bodies	body	NNS
cord-017527-ylng1us2	26	32	or	or	CC
cord-017527-ylng1us2	26	33	competent	competent	JJ
cord-017527-ylng1us2	26	34	authorities	authority	NNS
cord-017527-ylng1us2	26	35	(	(	-LRB-
cord-017527-ylng1us2	26	36	World	World	NNP
cord-017527-ylng1us2	26	37	Health	Health	NNP
cord-017527-ylng1us2	26	38	Organization	Organization	NNP
cord-017527-ylng1us2	26	39	2004	2004	CD
cord-017527-ylng1us2	26	40	;	;	:
cord-017527-ylng1us2	26	41	Centers	Centers	NNPS
cord-017527-ylng1us2	26	42	for	for	IN
cord-017527-ylng1us2	26	43	Disease	Disease	NNP
cord-017527-ylng1us2	26	44	Control	Control	NNP
cord-017527-ylng1us2	26	45	and	and	CC
cord-017527-ylng1us2	26	46	Prevention	Prevention	NNP
cord-017527-ylng1us2	26	47	2009a	2009a	CD
cord-017527-ylng1us2	26	48	;	;	:
cord-017527-ylng1us2	26	49	Swiss	Swiss	NNP
cord-017527-ylng1us2	26	50	Expert	Expert	NNP
cord-017527-ylng1us2	26	51	Committee	Committee	NNP
cord-017527-ylng1us2	26	52	for	for	IN
cord-017527-ylng1us2	26	53	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	26	54	2011	2011	CD
cord-017527-ylng1us2	26	55	)	)	-RRB-
cord-017527-ylng1us2	26	56	.	.	.
cord-017527-ylng1us2	27	1	While	while	IN
cord-017527-ylng1us2	27	2	biosafety	biosafety	NN
cord-017527-ylng1us2	27	3	recommendations	recommendation	NNS
cord-017527-ylng1us2	27	4	(	(	-LRB-
cord-017527-ylng1us2	27	5	as	as	IN
cord-017527-ylng1us2	27	6	outlined	outline	VBN
cord-017527-ylng1us2	27	7	hereafter	hereafter	RB
cord-017527-ylng1us2	27	8	)	)	-RRB-
cord-017527-ylng1us2	27	9	are	be	VBP
cord-017527-ylng1us2	27	10	principally	principally	RB
cord-017527-ylng1us2	27	11	aimed	aim	VBN
cord-017527-ylng1us2	27	12	at	at	IN
cord-017527-ylng1us2	27	13	providing	provide	VBG
cord-017527-ylng1us2	27	14	maximal	maximal	JJ
cord-017527-ylng1us2	27	15	protection	protection	NN
cord-017527-ylng1us2	27	16	of	of	IN
cord-017527-ylng1us2	27	17	human	human	JJ
cord-017527-ylng1us2	27	18	health	health	NN
cord-017527-ylng1us2	27	19	(	(	-LRB-
cord-017527-ylng1us2	27	20	including	include	VBG
cord-017527-ylng1us2	27	21	laboratory	laboratory	NN
cord-017527-ylng1us2	27	22	workers	worker	NNS
cord-017527-ylng1us2	27	23	)	)	-RRB-
cord-017527-ylng1us2	27	24	and	and	CC
cord-017527-ylng1us2	27	25	the	the	DT
cord-017527-ylng1us2	27	26	environment	environment	NN
cord-017527-ylng1us2	27	27	,	,	,
cord-017527-ylng1us2	27	28	it	-PRON-	PRP
cord-017527-ylng1us2	27	29	is	be	VBZ
cord-017527-ylng1us2	27	30	recognised	recognise	VBN
cord-017527-ylng1us2	27	31	that	that	IN
cord-017527-ylng1us2	27	32	many	many	JJ
cord-017527-ylng1us2	27	33	of	of	IN
cord-017527-ylng1us2	27	34	the	the	DT
cord-017527-ylng1us2	27	35	precautionary	precautionary	JJ
cord-017527-ylng1us2	27	36	measures	measure	NNS
cord-017527-ylng1us2	27	37	will	will	MD
cord-017527-ylng1us2	27	38	also	also	RB
cord-017527-ylng1us2	27	39	directly	directly	RB
cord-017527-ylng1us2	27	40	benefit	benefit	VB
cord-017527-ylng1us2	27	41	the	the	DT
cord-017527-ylng1us2	27	42	quality	quality	NN
cord-017527-ylng1us2	27	43	of	of	IN
cord-017527-ylng1us2	27	44	research	research	NN
cord-017527-ylng1us2	27	45	activities	activity	NNS
cord-017527-ylng1us2	27	46	involving	involve	VBG
cord-017527-ylng1us2	27	47	animal	animal	NN
cord-017527-ylng1us2	27	48	cell	cell	NN
cord-017527-ylng1us2	27	49	cultures	culture	NNS
cord-017527-ylng1us2	27	50	.	.	.
cord-017527-ylng1us2	28	1	Indeed	indeed	RB
cord-017527-ylng1us2	28	2	,	,	,
cord-017527-ylng1us2	28	3	cross	cross	NN
cord-017527-ylng1us2	28	4	-	-	NN
cord-017527-ylng1us2	28	5	contamination	contamination	NN
cord-017527-ylng1us2	28	6	(	(	-LRB-
cord-017527-ylng1us2	28	7	Lucey	Lucey	NNP
cord-017527-ylng1us2	28	8	et	et	NNP
cord-017527-ylng1us2	28	9	al	al	NNP
cord-017527-ylng1us2	28	10	.	.	.
cord-017527-ylng1us2	28	11	2009	2009	CD
cord-017527-ylng1us2	28	12	;	;	:
cord-017527-ylng1us2	28	13	Capes	Capes	NNPS
cord-017527-ylng1us2	28	14	-	-	HYPH
cord-017527-ylng1us2	28	15	Davis	Davis	NNP
cord-017527-ylng1us2	28	16	et	et	NNP
cord-017527-ylng1us2	28	17	al	al	NNP
cord-017527-ylng1us2	28	18	.	.	NNP
cord-017527-ylng1us2	28	19	2010	2010	CD
cord-017527-ylng1us2	28	20	;	;	:
cord-017527-ylng1us2	28	21	Stürzl	Stürzl	NNP
cord-017527-ylng1us2	28	22	et	et	NNP
cord-017527-ylng1us2	28	23	al	al	NNP
cord-017527-ylng1us2	28	24	.	.	.
cord-017527-ylng1us2	29	1	2013	2013	CD
cord-017527-ylng1us2	30	1	;	;	:
cord-017527-ylng1us2	30	2	Jäger	Jäger	NNP
cord-017527-ylng1us2	30	3	et	et	NNP
cord-017527-ylng1us2	30	4	al	al	NNP
cord-017527-ylng1us2	30	5	.	.	.
cord-017527-ylng1us2	31	1	2013	2013	CD
cord-017527-ylng1us2	31	2	;	;	:
cord-017527-ylng1us2	31	3	Johnen	Johnen	NNP
cord-017527-ylng1us2	31	4	et	et	NNP
cord-017527-ylng1us2	31	5	al	al	NNP
cord-017527-ylng1us2	31	6	.	.	.
cord-017527-ylng1us2	31	7	2013	2013	CD
cord-017527-ylng1us2	32	1	;	;	:
cord-017527-ylng1us2	32	2	MacLeod	MacLeod	NNP
cord-017527-ylng1us2	32	3	et	et	NNP
cord-017527-ylng1us2	32	4	al	al	NNP
cord-017527-ylng1us2	32	5	.	.	NNP
cord-017527-ylng1us2	32	6	2013	2013	CD
cord-017527-ylng1us2	32	7	)	)	-RRB-
cord-017527-ylng1us2	32	8	or	or	CC
cord-017527-ylng1us2	32	9	inadvertent	inadvertent	JJ
cord-017527-ylng1us2	32	10	contamination	contamination	NN
cord-017527-ylng1us2	32	11	with	with	IN
cord-017527-ylng1us2	32	12	infectious	infectious	JJ
cord-017527-ylng1us2	32	13	micro	micro	NNS
cord-017527-ylng1us2	32	14	-	-	HYPH
cord-017527-ylng1us2	32	15	organisms	organism	NNS
cord-017527-ylng1us2	32	16	(	(	-LRB-
cord-017527-ylng1us2	32	17	bacteria	bacteria	NNS
cord-017527-ylng1us2	32	18	,	,	,
cord-017527-ylng1us2	32	19	fungi	fungus	NNS
cord-017527-ylng1us2	32	20	,	,	,
cord-017527-ylng1us2	32	21	yeasts	yeast	NNS
cord-017527-ylng1us2	32	22	,	,	,
cord-017527-ylng1us2	32	23	virus	virus	NN
cord-017527-ylng1us2	32	24	,	,	,
cord-017527-ylng1us2	32	25	and	and	CC
cord-017527-ylng1us2	32	26	prion	prion	NN
cord-017527-ylng1us2	32	27	)	)	-RRB-
cord-017527-ylng1us2	32	28	are	be	VBP
cord-017527-ylng1us2	32	29	plaguing	plague	VBG
cord-017527-ylng1us2	32	30	many	many	JJ
cord-017527-ylng1us2	32	31	researchers	researcher	NNS
cord-017527-ylng1us2	32	32	,	,	,
cord-017527-ylng1us2	32	33	often	often	RB
cord-017527-ylng1us2	32	34	leading	lead	VBG
cord-017527-ylng1us2	32	35	to	to	IN
cord-017527-ylng1us2	32	36	unproductive	unproductive	JJ
cord-017527-ylng1us2	32	37	data	datum	NNS
cord-017527-ylng1us2	32	38	,	,	,
cord-017527-ylng1us2	32	39	misinterpretation	misinterpretation	NN
cord-017527-ylng1us2	32	40	of	of	IN
cord-017527-ylng1us2	32	41	results	result	NNS
cord-017527-ylng1us2	32	42	and	and	CC
cord-017527-ylng1us2	32	43	a	a	DT
cord-017527-ylng1us2	32	44	considerable	considerable	JJ
cord-017527-ylng1us2	32	45	waste	waste	NN
cord-017527-ylng1us2	32	46	of	of	IN
cord-017527-ylng1us2	32	47	time	time	NN
cord-017527-ylng1us2	32	48	and	and	CC
cord-017527-ylng1us2	32	49	energy	energy	NN
cord-017527-ylng1us2	32	50	(	(	-LRB-
cord-017527-ylng1us2	32	51	Mahy	Mahy	NNP
cord-017527-ylng1us2	32	52	et	et	FW
cord-017527-ylng1us2	32	53	al	al	NNP
cord-017527-ylng1us2	32	54	.	.	.
cord-017527-ylng1us2	32	55	1991	1991	CD
cord-017527-ylng1us2	32	56	;	;	:
cord-017527-ylng1us2	32	57	Drexler	Drexler	NNP
cord-017527-ylng1us2	32	58	and	and	CC
cord-017527-ylng1us2	32	59	Uphoff	Uphoff	NNP
cord-017527-ylng1us2	32	60	2000	2000	CD
cord-017527-ylng1us2	32	61	;	;	:
cord-017527-ylng1us2	32	62	Mirjalili	Mirjalili	NNP
cord-017527-ylng1us2	32	63	et	et	NNP
cord-017527-ylng1us2	32	64	al	al	NNP
cord-017527-ylng1us2	32	65	.	.	NNP
cord-017527-ylng1us2	32	66	2005	2005	CD
cord-017527-ylng1us2	32	67	;	;	:
cord-017527-ylng1us2	32	68	Cobo	Cobo	NNP
cord-017527-ylng1us2	32	69	et	et	NNP
cord-017527-ylng1us2	32	70	al	al	NNP
cord-017527-ylng1us2	32	71	.	.	NNP
cord-017527-ylng1us2	32	72	2007	2007	CD
cord-017527-ylng1us2	32	73	;	;	:
cord-017527-ylng1us2	32	74	Pinheiro	Pinheiro	NNP
cord-017527-ylng1us2	32	75	de	de	NNP
cord-017527-ylng1us2	32	76	Oliveira	Oliveira	NNP
cord-017527-ylng1us2	32	77	et	et	NNP
cord-017527-ylng1us2	32	78	al	al	NNP
cord-017527-ylng1us2	32	79	.	.	NNP
cord-017527-ylng1us2	32	80	2013	2013	CD
cord-017527-ylng1us2	32	81	)	)	-RRB-
cord-017527-ylng1us2	32	82	.	.	.
cord-017527-ylng1us2	33	1	It	-PRON-	PRP
cord-017527-ylng1us2	33	2	should	should	MD
cord-017527-ylng1us2	33	3	also	also	RB
cord-017527-ylng1us2	33	4	be	be	VB
cord-017527-ylng1us2	33	5	emphasized	emphasize	VBN
cord-017527-ylng1us2	33	6	that	that	IN
cord-017527-ylng1us2	33	7	even	even	RB
cord-017527-ylng1us2	33	8	if	if	IN
cord-017527-ylng1us2	33	9	Good	Good	NNP
cord-017527-ylng1us2	33	10	Manufacturing	Manufacturing	NNP
cord-017527-ylng1us2	33	11	Process	Process	NNP
cord-017527-ylng1us2	33	12	(	(	-LRB-
cord-017527-ylng1us2	33	13	GMP	GMP	NNP
cord-017527-ylng1us2	33	14	)	)	-RRB-
cord-017527-ylng1us2	33	15	aim	aim	VBP
cord-017527-ylng1us2	33	16	at	at	IN
cord-017527-ylng1us2	33	17	protecting	protect	VBG
cord-017527-ylng1us2	33	18	the	the	DT
cord-017527-ylng1us2	33	19	product	product	NN
cord-017527-ylng1us2	33	20	,	,	,
cord-017527-ylng1us2	33	21	some	some	DT
cord-017527-ylng1us2	33	22	of	of	IN
cord-017527-ylng1us2	33	23	the	the	DT
cord-017527-ylng1us2	33	24	GMP	GMP	NNP
cord-017527-ylng1us2	33	25	measures	measure	NNS
cord-017527-ylng1us2	33	26	are	be	VBP
cord-017527-ylng1us2	33	27	compatible	compatible	JJ
cord-017527-ylng1us2	33	28	with	with	IN
cord-017527-ylng1us2	33	29	biosafety	biosafety	NN
cord-017527-ylng1us2	33	30	measures	measure	NNS
cord-017527-ylng1us2	33	31	and	and	CC
cord-017527-ylng1us2	33	32	reveal	reveal	VB
cord-017527-ylng1us2	33	33	to	to	TO
cord-017527-ylng1us2	33	34	be	be	VB
cord-017527-ylng1us2	33	35	complementary	complementary	JJ
cord-017527-ylng1us2	33	36	.	.	.
cord-017527-ylng1us2	34	1	The	the	DT
cord-017527-ylng1us2	34	2	objective	objective	NN
cord-017527-ylng1us2	34	3	of	of	IN
cord-017527-ylng1us2	34	4	this	this	DT
cord-017527-ylng1us2	34	5	chapter	chapter	NN
cord-017527-ylng1us2	34	6	will	will	MD
cord-017527-ylng1us2	34	7	be	be	VB
cord-017527-ylng1us2	34	8	to	to	TO
cord-017527-ylng1us2	34	9	address	address	VB
cord-017527-ylng1us2	34	10	and	and	CC
cord-017527-ylng1us2	34	11	review	review	VB
cord-017527-ylng1us2	34	12	biorisk	biorisk	NNP
cord-017527-ylng1us2	34	13	assessment	assessment	NN
cord-017527-ylng1us2	34	14	and	and	CC
cord-017527-ylng1us2	34	15	management	management	NN
cord-017527-ylng1us2	34	16	considerations	consideration	NNS
cord-017527-ylng1us2	34	17	of	of	IN
cord-017527-ylng1us2	34	18	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	34	19	and	and	CC
cord-017527-ylng1us2	34	20	research	research	NN
cord-017527-ylng1us2	34	21	activities	activity	NNS
cord-017527-ylng1us2	34	22	involving	involve	VBG
cord-017527-ylng1us2	34	23	cell	cell	NN
cord-017527-ylng1us2	34	24	cultures	culture	NNS
cord-017527-ylng1us2	34	25	.	.	.
cord-017527-ylng1us2	35	1	From	from	IN
cord-017527-ylng1us2	35	2	an	an	DT
cord-017527-ylng1us2	35	3	historical	historical	JJ
cord-017527-ylng1us2	35	4	perspective	perspective	NN
cord-017527-ylng1us2	35	5	,	,	,
cord-017527-ylng1us2	35	6	the	the	DT
cord-017527-ylng1us2	35	7	assessment	assessment	NN
cord-017527-ylng1us2	35	8	of	of	IN
cord-017527-ylng1us2	35	9	biological	biological	JJ
cord-017527-ylng1us2	35	10	risks	risk	NNS
cord-017527-ylng1us2	35	11	has	have	VBZ
cord-017527-ylng1us2	35	12	an	an	DT
cord-017527-ylng1us2	35	13	empirical	empirical	JJ
cord-017527-ylng1us2	35	14	basis	basis	NN
cord-017527-ylng1us2	35	15	and	and	CC
cord-017527-ylng1us2	35	16	has	have	VBZ
cord-017527-ylng1us2	35	17	resulted	result	VBN
cord-017527-ylng1us2	35	18	from	from	IN
cord-017527-ylng1us2	35	19	the	the	DT
cord-017527-ylng1us2	35	20	awareness	awareness	NN
cord-017527-ylng1us2	35	21	of	of	IN
cord-017527-ylng1us2	35	22	the	the	DT
cord-017527-ylng1us2	35	23	scientific	scientific	JJ
cord-017527-ylng1us2	35	24	community	community	NN
cord-017527-ylng1us2	35	25	with	with	IN
cord-017527-ylng1us2	35	26	regards	regard	VBZ
cord-017527-ylng1us2	35	27	the	the	DT
cord-017527-ylng1us2	35	28	risks	risk	NNS
cord-017527-ylng1us2	35	29	associated	associate	VBN
cord-017527-ylng1us2	35	30	with	with	IN
cord-017527-ylng1us2	35	31	the	the	DT
cord-017527-ylng1us2	35	32	handling	handling	NN
cord-017527-ylng1us2	35	33	of	of	IN
cord-017527-ylng1us2	35	34	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	35	35	organisms	organism	NNS
cord-017527-ylng1us2	35	36	,	,	,
cord-017527-ylng1us2	35	37	as	as	IN
cord-017527-ylng1us2	35	38	demonstrated	demonstrate	VBN
cord-017527-ylng1us2	35	39	through	through	IN
cord-017527-ylng1us2	35	40	many	many	JJ
cord-017527-ylng1us2	35	41	reported	report	VBN
cord-017527-ylng1us2	35	42	cases	case	NNS
cord-017527-ylng1us2	35	43	of	of	IN
cord-017527-ylng1us2	35	44	laboratory	laboratory	NN
cord-017527-ylng1us2	35	45	-	-	HYPH
cord-017527-ylng1us2	35	46	acquired	acquire	VBN
cord-017527-ylng1us2	35	47	infections	infection	NNS
cord-017527-ylng1us2	35	48	,	,	,
cord-017527-ylng1us2	35	49	followed	follow	VBN
cord-017527-ylng1us2	35	50	by	by	IN
cord-017527-ylng1us2	35	51	the	the	DT
cord-017527-ylng1us2	35	52	potential	potential	JJ
cord-017527-ylng1us2	35	53	risks	risk	NNS
cord-017527-ylng1us2	35	54	associated	associate	VBN
cord-017527-ylng1us2	35	55	with	with	IN
cord-017527-ylng1us2	35	56	experiments	experiment	NNS
cord-017527-ylng1us2	35	57	involving	involve	VBG
cord-017527-ylng1us2	35	58	recombinant	recombinant	JJ
cord-017527-ylng1us2	35	59	DNA	dna	NN
cord-017527-ylng1us2	35	60	.	.	.
cord-017527-ylng1us2	36	1	In	in	IN
cord-017527-ylng1us2	36	2	the	the	DT
cord-017527-ylng1us2	36	3	1970s	1970	NNS
cord-017527-ylng1us2	36	4	,	,	,
cord-017527-ylng1us2	36	5	some	some	DT
cord-017527-ylng1us2	36	6	initiatives	initiative	NNS
cord-017527-ylng1us2	36	7	for	for	IN
cord-017527-ylng1us2	36	8	implementing	implement	VBG
cord-017527-ylng1us2	36	9	measures	measure	NNS
cord-017527-ylng1us2	36	10	guaranteeing	guarantee	VBG
cord-017527-ylng1us2	36	11	the	the	DT
cord-017527-ylng1us2	36	12	safe	safe	JJ
cord-017527-ylng1us2	36	13	use	use	NN
cord-017527-ylng1us2	36	14	of	of	IN
cord-017527-ylng1us2	36	15	recombinant	recombinant	JJ
cord-017527-ylng1us2	36	16	DNA	dna	NN
cord-017527-ylng1us2	36	17	were	be	VBD
cord-017527-ylng1us2	36	18	linked	link	VBN
cord-017527-ylng1us2	36	19	to	to	IN
cord-017527-ylng1us2	36	20	the	the	DT
cord-017527-ylng1us2	36	21	safety	safety	NN
cord-017527-ylng1us2	36	22	measures	measure	NNS
cord-017527-ylng1us2	36	23	which	which	WDT
cord-017527-ylng1us2	36	24	were	be	VBD
cord-017527-ylng1us2	36	25	at	at	IN
cord-017527-ylng1us2	36	26	that	that	DT
cord-017527-ylng1us2	36	27	time	time	NN
cord-017527-ylng1us2	36	28	already	already	RB
cord-017527-ylng1us2	36	29	successfully	successfully	RB
cord-017527-ylng1us2	36	30	applied	apply	VBN
cord-017527-ylng1us2	36	31	in	in	IN
cord-017527-ylng1us2	36	32	microbiology	microbiology	NN
cord-017527-ylng1us2	36	33	for	for	IN
cord-017527-ylng1us2	36	34	the	the	DT
cord-017527-ylng1us2	36	35	containment	containment	NN
cord-017527-ylng1us2	36	36	of	of	IN
cord-017527-ylng1us2	36	37	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	36	38	organisms	organism	NNS
cord-017527-ylng1us2	36	39	(	(	-LRB-
cord-017527-ylng1us2	36	40	National	National	NNP
cord-017527-ylng1us2	36	41	Institute	Institute	NNP
cord-017527-ylng1us2	36	42	of	of	IN
cord-017527-ylng1us2	36	43	Health	Health	NNP
cord-017527-ylng1us2	36	44	1979	1979	CD
cord-017527-ylng1us2	36	45	)	)	-RRB-
cord-017527-ylng1us2	36	46	.	.	.
cord-017527-ylng1us2	37	1	The	the	DT
cord-017527-ylng1us2	37	2	conjunction	conjunction	NN
cord-017527-ylng1us2	37	3	of	of	IN
cord-017527-ylng1us2	37	4	these	these	DT
cord-017527-ylng1us2	37	5	two	two	CD
cord-017527-ylng1us2	37	6	aspects	aspect	NNS
cord-017527-ylng1us2	37	7	constitutes	constitute	VBZ
cord-017527-ylng1us2	37	8	two	two	CD
cord-017527-ylng1us2	37	9	pillars	pillar	NNS
cord-017527-ylng1us2	37	10	of	of	IN
cord-017527-ylng1us2	37	11	biosafety	biosafety	NN
cord-017527-ylng1us2	37	12	and	and	CC
cord-017527-ylng1us2	37	13	has	have	VBZ
cord-017527-ylng1us2	37	14	led	lead	VBN
cord-017527-ylng1us2	37	15	to	to	IN
cord-017527-ylng1us2	37	16	a	a	DT
cord-017527-ylng1us2	37	17	classification	classification	NN
cord-017527-ylng1us2	37	18	system	system	NN
cord-017527-ylng1us2	37	19	of	of	IN
cord-017527-ylng1us2	37	20	organisms	organism	NNS
cord-017527-ylng1us2	37	21	into	into	IN
cord-017527-ylng1us2	37	22	risk	risk	NN
cord-017527-ylng1us2	37	23	classes	class	NNS
cord-017527-ylng1us2	37	24	or	or	CC
cord-017527-ylng1us2	37	25	risk	risk	NN
cord-017527-ylng1us2	37	26	groups	group	NNS
cord-017527-ylng1us2	37	27	.	.	.
cord-017527-ylng1us2	38	1	So	so	RB
cord-017527-ylng1us2	38	2	far	far	RB
cord-017527-ylng1us2	38	3	,	,	,
cord-017527-ylng1us2	38	4	many	many	JJ
cord-017527-ylng1us2	38	5	risk	risk	NN
cord-017527-ylng1us2	38	6	assessments	assessment	NNS
cord-017527-ylng1us2	38	7	have	have	VBP
cord-017527-ylng1us2	38	8	been	be	VBN
cord-017527-ylng1us2	38	9	carried	carry	VBN
cord-017527-ylng1us2	38	10	out	out	RP
cord-017527-ylng1us2	38	11	among	among	IN
cord-017527-ylng1us2	38	12	the	the	DT
cord-017527-ylng1us2	38	13	scientific	scientific	JJ
cord-017527-ylng1us2	38	14	community	community	NN
cord-017527-ylng1us2	38	15	on	on	IN
cord-017527-ylng1us2	38	16	the	the	DT
cord-017527-ylng1us2	38	17	use	use	NN
cord-017527-ylng1us2	38	18	of	of	IN
cord-017527-ylng1us2	38	19	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	38	20	organisms	organism	NNS
cord-017527-ylng1us2	38	21	(	(	-LRB-
cord-017527-ylng1us2	38	22	genetically	genetically	RB
cord-017527-ylng1us2	38	23	modified	modify	VBN
cord-017527-ylng1us2	38	24	or	or	CC
cord-017527-ylng1us2	38	25	not	not	RB
cord-017527-ylng1us2	38	26	)	)	-RRB-
cord-017527-ylng1us2	38	27	,	,	,
cord-017527-ylng1us2	38	28	regardless	regardless	RB
cord-017527-ylng1us2	38	29	of	of	IN
cord-017527-ylng1us2	38	30	the	the	DT
cord-017527-ylng1us2	38	31	scale	scale	NN
cord-017527-ylng1us2	38	32	or	or	CC
cord-017527-ylng1us2	38	33	the	the	DT
cord-017527-ylng1us2	38	34	purpose	purpose	NN
cord-017527-ylng1us2	38	35	of	of	IN
cord-017527-ylng1us2	38	36	the	the	DT
cord-017527-ylng1us2	38	37	activity	activity	NN
cord-017527-ylng1us2	38	38	.	.	.
cord-017527-ylng1us2	39	1	The	the	DT
cord-017527-ylng1us2	39	2	basis	basis	NN
cord-017527-ylng1us2	39	3	for	for	IN
cord-017527-ylng1us2	39	4	this	this	DT
cord-017527-ylng1us2	39	5	risk	risk	NN
cord-017527-ylng1us2	39	6	assessment	assessment	NN
cord-017527-ylng1us2	39	7	methodology	methodology	NN
cord-017527-ylng1us2	39	8	takes	take	VBZ
cord-017527-ylng1us2	39	9	into	into	IN
cord-017527-ylng1us2	39	10	account	account	NN
cord-017527-ylng1us2	39	11	the	the	DT
cord-017527-ylng1us2	39	12	most	most	RBS
cord-017527-ylng1us2	39	13	recent	recent	JJ
cord-017527-ylng1us2	39	14	scientific	scientific	JJ
cord-017527-ylng1us2	39	15	,	,	,
cord-017527-ylng1us2	39	16	technical	technical	JJ
cord-017527-ylng1us2	39	17	data	datum	NNS
cord-017527-ylng1us2	39	18	and	and	CC
cord-017527-ylng1us2	39	19	uses	use	VBZ
cord-017527-ylng1us2	39	20	a	a	DT
cord-017527-ylng1us2	39	21	scientifically	scientifically	RB
cord-017527-ylng1us2	39	22	sound	sound	JJ
cord-017527-ylng1us2	39	23	approach	approach	NN
cord-017527-ylng1us2	39	24	.	.	.
cord-017527-ylng1us2	40	1	The	the	DT
cord-017527-ylng1us2	40	2	methodology	methodology	NN
cord-017527-ylng1us2	40	3	of	of	IN
cord-017527-ylng1us2	40	4	biological	biological	JJ
cord-017527-ylng1us2	40	5	risk	risk	NN
cord-017527-ylng1us2	40	6	assessment	assessment	NN
cord-017527-ylng1us2	40	7	of	of	IN
cord-017527-ylng1us2	40	8	contained	contain	VBN
cord-017527-ylng1us2	40	9	use	use	NN
cord-017527-ylng1us2	40	10	activities	activity	NNS
cord-017527-ylng1us2	40	11	involving	involve	VBG
cord-017527-ylng1us2	40	12	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	40	13	and/or	and/or	CC
cord-017527-ylng1us2	40	14	genetically	genetically	RB
cord-017527-ylng1us2	40	15	modified	modify	VBN
cord-017527-ylng1us2	40	16	organisms	organism	NNS
cord-017527-ylng1us2	40	17	(	(	-LRB-
cord-017527-ylng1us2	40	18	GMO	GMO	NNP
cord-017527-ylng1us2	40	19	)	)	-RRB-
cord-017527-ylng1us2	40	20	identifies	identify	VBZ
cord-017527-ylng1us2	40	21	and	and	CC
cord-017527-ylng1us2	40	22	takes	take	VBZ
cord-017527-ylng1us2	40	23	into	into	IN
cord-017527-ylng1us2	40	24	account	account	NN
cord-017527-ylng1us2	40	25	the	the	DT
cord-017527-ylng1us2	40	26	probability	probability	NN
cord-017527-ylng1us2	40	27	of	of	IN
cord-017527-ylng1us2	40	28	occurrence	occurrence	NN
cord-017527-ylng1us2	40	29	and	and	CC
cord-017527-ylng1us2	40	30	the	the	DT
cord-017527-ylng1us2	40	31	severity	severity	NN
cord-017527-ylng1us2	40	32	of	of	IN
cord-017527-ylng1us2	40	33	a	a	DT
cord-017527-ylng1us2	40	34	potential	potential	JJ
cord-017527-ylng1us2	40	35	negative	negative	JJ
cord-017527-ylng1us2	40	36	effect	effect	NN
cord-017527-ylng1us2	40	37	on	on	IN
cord-017527-ylng1us2	40	38	public	public	JJ
cord-017527-ylng1us2	40	39	health	health	NN
cord-017527-ylng1us2	40	40	(	(	-LRB-
cord-017527-ylng1us2	40	41	including	include	VBG
cord-017527-ylng1us2	40	42	the	the	DT
cord-017527-ylng1us2	40	43	exposed	expose	VBN
cord-017527-ylng1us2	40	44	workers	worker	NNS
cord-017527-ylng1us2	40	45	)	)	-RRB-
cord-017527-ylng1us2	40	46	and/or	and/or	CC
cord-017527-ylng1us2	40	47	the	the	DT
cord-017527-ylng1us2	40	48	environment	environment	NN
cord-017527-ylng1us2	40	49	.	.	.
cord-017527-ylng1us2	41	1	As	as	IN
cord-017527-ylng1us2	41	2	a	a	DT
cord-017527-ylng1us2	41	3	result	result	NN
cord-017527-ylng1us2	41	4	of	of	IN
cord-017527-ylng1us2	41	5	this	this	DT
cord-017527-ylng1us2	41	6	methodology	methodology	NN
cord-017527-ylng1us2	41	7	,	,	,
cord-017527-ylng1us2	41	8	a	a	DT
cord-017527-ylng1us2	41	9	well	well	RB
cord-017527-ylng1us2	41	10	characterised	characterise	VBN
cord-017527-ylng1us2	41	11	risk	risk	NN
cord-017527-ylng1us2	41	12	will	will	MD
cord-017527-ylng1us2	41	13	lead	lead	VB
cord-017527-ylng1us2	41	14	to	to	IN
cord-017527-ylng1us2	41	15	the	the	DT
cord-017527-ylng1us2	41	16	choice	choice	NN
cord-017527-ylng1us2	41	17	of	of	IN
cord-017527-ylng1us2	41	18	appropriate	appropriate	JJ
cord-017527-ylng1us2	41	19	preventive	preventive	JJ
cord-017527-ylng1us2	41	20	measures	measure	NNS
cord-017527-ylng1us2	41	21	encompassing	encompass	VBG
cord-017527-ylng1us2	41	22	the	the	DT
cord-017527-ylng1us2	41	23	adoption	adoption	NN
cord-017527-ylng1us2	41	24	of	of	IN
cord-017527-ylng1us2	41	25	an	an	DT
cord-017527-ylng1us2	41	26	appropriate	appropriate	JJ
cord-017527-ylng1us2	41	27	containment	containment	NN
cord-017527-ylng1us2	41	28	level	level	NN
cord-017527-ylng1us2	41	29	,	,	,
cord-017527-ylng1us2	41	30	the	the	DT
cord-017527-ylng1us2	41	31	use	use	NN
cord-017527-ylng1us2	41	32	of	of	IN
cord-017527-ylng1us2	41	33	safety	safety	NN
cord-017527-ylng1us2	41	34	equipment	equipment	NN
cord-017527-ylng1us2	41	35	including	include	VBG
cord-017527-ylng1us2	41	36	personal	personal	JJ
cord-017527-ylng1us2	41	37	protective	protective	JJ
cord-017527-ylng1us2	41	38	equipment	equipment	NN
cord-017527-ylng1us2	41	39	,	,	,
cord-017527-ylng1us2	41	40	work	work	NN
cord-017527-ylng1us2	41	41	practices	practice	NNS
cord-017527-ylng1us2	41	42	and	and	CC
cord-017527-ylng1us2	41	43	waste	waste	NN
cord-017527-ylng1us2	41	44	management	management	NN
cord-017527-ylng1us2	41	45	.	.	.
cord-017527-ylng1us2	42	1	The	the	DT
cord-017527-ylng1us2	42	2	risk	risk	NN
cord-017527-ylng1us2	42	3	assessment	assessment	NN
cord-017527-ylng1us2	42	4	methodology	methodology	NN
cord-017527-ylng1us2	42	5	is	be	VBZ
cord-017527-ylng1us2	42	6	commonly	commonly	RB
cord-017527-ylng1us2	42	7	used	use	VBN
cord-017527-ylng1us2	42	8	and	and	CC
cord-017527-ylng1us2	42	9	its	-PRON-	PRP$
cord-017527-ylng1us2	42	10	4-step	4-step	CD
cord-017527-ylng1us2	42	11	approach	approach	NN
cord-017527-ylng1us2	42	12	is	be	VBZ
cord-017527-ylng1us2	42	13	described	describe	VBN
cord-017527-ylng1us2	42	14	in	in	IN
cord-017527-ylng1us2	42	15	Fig	Fig	NNP
cord-017527-ylng1us2	42	16	.	.	.
cord-017527-ylng1us2	43	1	22	22	CD
cord-017527-ylng1us2	43	2	.1	.1	NNS
cord-017527-ylng1us2	43	3	.	.	.
cord-017527-ylng1us2	44	1	The	the	DT
cord-017527-ylng1us2	44	2	first	first	JJ
cord-017527-ylng1us2	44	3	step	step	NN
cord-017527-ylng1us2	44	4	(	(	-LRB-
cord-017527-ylng1us2	44	5	1	1	CD
cord-017527-ylng1us2	44	6	)	)	-RRB-
cord-017527-ylng1us2	44	7	takes	take	VBZ
cord-017527-ylng1us2	44	8	into	into	IN
cord-017527-ylng1us2	44	9	account	account	NN
cord-017527-ylng1us2	44	10	the	the	DT
cord-017527-ylng1us2	44	11	characteristics	characteristic	NNS
cord-017527-ylng1us2	44	12	of	of	IN
cord-017527-ylng1us2	44	13	the	the	DT
cord-017527-ylng1us2	44	14	organism(s	organism(s	NNP
cord-017527-ylng1us2	44	15	)	)	-RRB-
cord-017527-ylng1us2	44	16	used	use	VBD
cord-017527-ylng1us2	44	17	and	and	CC
cord-017527-ylng1us2	44	18	,	,	,
cord-017527-ylng1us2	44	19	in	in	IN
cord-017527-ylng1us2	44	20	the	the	DT
cord-017527-ylng1us2	44	21	case	case	NN
cord-017527-ylng1us2	44	22	of	of	IN
cord-017527-ylng1us2	44	23	genetic	genetic	JJ
cord-017527-ylng1us2	44	24	modification	modification	NN
cord-017527-ylng1us2	44	25	,	,	,
cord-017527-ylng1us2	44	26	the	the	DT
cord-017527-ylng1us2	44	27	genetic	genetic	JJ
cord-017527-ylng1us2	44	28	material	material	NN
cord-017527-ylng1us2	44	29	introduced	introduce	VBN
cord-017527-ylng1us2	44	30	and	and	CC
cord-017527-ylng1us2	44	31	the	the	DT
cord-017527-ylng1us2	44	32	resulting	result	VBG
cord-017527-ylng1us2	44	33	GMO	GMO	NNP
cord-017527-ylng1us2	44	34	.	.	.
cord-017527-ylng1us2	45	1	Based	base	VBN
cord-017527-ylng1us2	45	2	on	on	IN
cord-017527-ylng1us2	45	3	information	information	NN
cord-017527-ylng1us2	45	4	relative	relative	JJ
cord-017527-ylng1us2	45	5	to	to	IN
cord-017527-ylng1us2	45	6	their	-PRON-	PRP$
cord-017527-ylng1us2	45	7	harmful	harmful	JJ
cord-017527-ylng1us2	45	8	characteristics	characteristic	NNS
cord-017527-ylng1us2	45	9	,	,	,
cord-017527-ylng1us2	45	10	natural	natural	JJ
cord-017527-ylng1us2	45	11	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	45	12	micro	micro	NNS
cord-017527-ylng1us2	45	13	-	-	NNS
cord-017527-ylng1us2	45	14	organisms	organism	NNS
cord-017527-ylng1us2	45	15	can	can	MD
cord-017527-ylng1us2	45	16	be	be	VB
cord-017527-ylng1us2	45	17	categorised	categorise	VBN
cord-017527-ylng1us2	45	18	in	in	IN
cord-017527-ylng1us2	45	19	several	several	JJ
cord-017527-ylng1us2	45	20	classes	class	NNS
cord-017527-ylng1us2	45	21	of	of	IN
cord-017527-ylng1us2	45	22	risk	risk	NN
cord-017527-ylng1us2	45	23	or	or	CC
cord-017527-ylng1us2	45	24	risk	risk	NN
cord-017527-ylng1us2	45	25	groups	group	NNS
cord-017527-ylng1us2	45	26	.	.	.
cord-017527-ylng1us2	46	1	This	this	DT
cord-017527-ylng1us2	46	2	classification	classification	NN
cord-017527-ylng1us2	46	3	takes	take	VBZ
cord-017527-ylng1us2	46	4	into	into	IN
cord-017527-ylng1us2	46	5	account	account	NN
cord-017527-ylng1us2	46	6	the	the	DT
cord-017527-ylng1us2	46	7	severity	severity	NN
cord-017527-ylng1us2	46	8	of	of	IN
cord-017527-ylng1us2	46	9	the	the	DT
cord-017527-ylng1us2	46	10	disease	disease	NN
cord-017527-ylng1us2	46	11	that	that	WDT
cord-017527-ylng1us2	46	12	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	46	13	organisms	organism	NNS
cord-017527-ylng1us2	46	14	may	may	MD
cord-017527-ylng1us2	46	15	cause	cause	VB
cord-017527-ylng1us2	46	16	to	to	IN
cord-017527-ylng1us2	46	17	human	human	JJ
cord-017527-ylng1us2	46	18	or	or	CC
cord-017527-ylng1us2	46	19	animal	animal	NN
cord-017527-ylng1us2	46	20	health	health	NN
cord-017527-ylng1us2	46	21	,	,	,
cord-017527-ylng1us2	46	22	their	-PRON-	PRP$
cord-017527-ylng1us2	46	23	ability	ability	NN
cord-017527-ylng1us2	46	24	to	to	TO
cord-017527-ylng1us2	46	25	spread	spread	VB
cord-017527-ylng1us2	46	26	amongst	amongst	IN
cord-017527-ylng1us2	46	27	the	the	DT
cord-017527-ylng1us2	46	28	population	population	NN
cord-017527-ylng1us2	46	29	and	and	CC
cord-017527-ylng1us2	46	30	the	the	DT
cord-017527-ylng1us2	46	31	availability	availability	NN
cord-017527-ylng1us2	46	32	of	of	IN
cord-017527-ylng1us2	46	33	prophylaxis	prophylaxis	NN
cord-017527-ylng1us2	46	34	or	or	CC
cord-017527-ylng1us2	46	35	efficient	efficient	JJ
cord-017527-ylng1us2	46	36	treatment	treatment	NN
cord-017527-ylng1us2	46	37	(	(	-LRB-
cord-017527-ylng1us2	46	38	World	World	NNP
cord-017527-ylng1us2	46	39	Health	Health	NNP
cord-017527-ylng1us2	46	40	Organization	Organization	NNP
cord-017527-ylng1us2	46	41	2004	2004	CD
cord-017527-ylng1us2	46	42	)	)	-RRB-
cord-017527-ylng1us2	46	43	.	.	.
cord-017527-ylng1us2	47	1	For	for	IN
cord-017527-ylng1us2	47	2	zoopathogens	zoopathogens	NNP
cord-017527-ylng1us2	47	3	,	,	,
cord-017527-ylng1us2	47	4	the	the	DT
cord-017527-ylng1us2	47	5	classification	classification	NN
cord-017527-ylng1us2	47	6	system	system	NN
cord-017527-ylng1us2	47	7	is	be	VBZ
cord-017527-ylng1us2	47	8	mainly	mainly	RB
cord-017527-ylng1us2	47	9	based	base	VBN
cord-017527-ylng1us2	47	10	on	on	IN
cord-017527-ylng1us2	47	11	the	the	DT
cord-017527-ylng1us2	47	12	definitions	definition	NNS
cord-017527-ylng1us2	47	13	of	of	IN
cord-017527-ylng1us2	47	14	the	the	DT
cord-017527-ylng1us2	47	15	World	World	NNP
cord-017527-ylng1us2	47	16	Organisation	Organisation	NNP
cord-017527-ylng1us2	47	17	of	of	IN
cord-017527-ylng1us2	47	18	Animal	Animal	NNP
cord-017527-ylng1us2	47	19	Health	Health	NNP
cord-017527-ylng1us2	47	20	(	(	-LRB-
cord-017527-ylng1us2	47	21	OIE	OIE	NNP
cord-017527-ylng1us2	47	22	)	)	-RRB-
cord-017527-ylng1us2	47	23	,	,	,
cord-017527-ylng1us2	47	24	which	which	WDT
cord-017527-ylng1us2	47	25	categorises	categorise	VBZ
cord-017527-ylng1us2	47	26	animal	animal	NN
cord-017527-ylng1us2	47	27	pathogens	pathogen	NNS
cord-017527-ylng1us2	47	28	into	into	IN
cord-017527-ylng1us2	47	29	four	four	CD
cord-017527-ylng1us2	47	30	groups	group	NNS
cord-017527-ylng1us2	47	31	according	accord	VBG
cord-017527-ylng1us2	47	32	to	to	IN
cord-017527-ylng1us2	47	33	their	-PRON-	PRP$
cord-017527-ylng1us2	47	34	risk	risk	NN
cord-017527-ylng1us2	47	35	to	to	IN
cord-017527-ylng1us2	47	36	animal	animal	NN
cord-017527-ylng1us2	47	37	health	health	NN
cord-017527-ylng1us2	47	38	,	,	,
cord-017527-ylng1us2	47	39	and	and	CC
cord-017527-ylng1us2	47	40	since	since	IN
cord-017527-ylng1us2	47	41	2008	2008	CD
cord-017527-ylng1us2	47	42	,	,	,
cord-017527-ylng1us2	47	43	their	-PRON-	PRP$
cord-017527-ylng1us2	47	44	risk	risk	NN
cord-017527-ylng1us2	47	45	to	to	IN
cord-017527-ylng1us2	47	46	human	human	JJ
cord-017527-ylng1us2	47	47	health	health	NN
cord-017527-ylng1us2	47	48	as	as	RB
cord-017527-ylng1us2	47	49	well	well	RB
cord-017527-ylng1us2	47	50	(	(	-LRB-
cord-017527-ylng1us2	47	51	World	World	NNP
cord-017527-ylng1us2	47	52	Organisation	Organisation	NNP
cord-017527-ylng1us2	47	53	for	for	IN
cord-017527-ylng1us2	47	54	Animal	Animal	NNP
cord-017527-ylng1us2	47	55	Health	Health	NNP
cord-017527-ylng1us2	47	56	2009	2009	CD
cord-017527-ylng1us2	47	57	)	)	-RRB-
cord-017527-ylng1us2	47	58	.	.	.
cord-017527-ylng1us2	48	1	Micro	Micro	NNS
cord-017527-ylng1us2	48	2	-	-	HYPH
cord-017527-ylng1us2	48	3	organisms	organism	NNS
cord-017527-ylng1us2	48	4	that	that	WDT
cord-017527-ylng1us2	48	5	are	be	VBP
cord-017527-ylng1us2	48	6	unlikely	unlikely	JJ
cord-017527-ylng1us2	48	7	to	to	TO
cord-017527-ylng1us2	48	8	cause	cause	VB
cord-017527-ylng1us2	48	9	disease	disease	NN
cord-017527-ylng1us2	48	10	are	be	VBP
cord-017527-ylng1us2	48	11	classified	classify	VBN
cord-017527-ylng1us2	48	12	into	into	IN
cord-017527-ylng1us2	48	13	class	class	NN
cord-017527-ylng1us2	48	14	of	of	IN
cord-017527-ylng1us2	48	15	risk	risk	NN
cord-017527-ylng1us2	48	16	1	1	CD
cord-017527-ylng1us2	48	17	while	while	IN
cord-017527-ylng1us2	48	18	etiologic	etiologic	JJ
cord-017527-ylng1us2	48	19	agents	agent	NNS
cord-017527-ylng1us2	48	20	responsible	responsible	JJ
cord-017527-ylng1us2	48	21	for	for	IN
cord-017527-ylng1us2	48	22	severe	severe	JJ
cord-017527-ylng1us2	48	23	diseases	disease	NNS
cord-017527-ylng1us2	48	24	with	with	IN
cord-017527-ylng1us2	48	25	a	a	DT
cord-017527-ylng1us2	48	26	high	high	JJ
cord-017527-ylng1us2	48	27	potential	potential	NN
cord-017527-ylng1us2	48	28	of	of	IN
cord-017527-ylng1us2	48	29	transmissibility	transmissibility	NN
cord-017527-ylng1us2	48	30	and	and	CC
cord-017527-ylng1us2	48	31	for	for	IN
cord-017527-ylng1us2	48	32	which	which	WDT
cord-017527-ylng1us2	48	33	no	no	DT
cord-017527-ylng1us2	48	34	prophylaxis	prophylaxis	NN
cord-017527-ylng1us2	48	35	or	or	CC
cord-017527-ylng1us2	48	36	treatment	treatment	NN
cord-017527-ylng1us2	48	37	is	be	VBZ
cord-017527-ylng1us2	48	38	available	available	JJ
cord-017527-ylng1us2	48	39	are	be	VBP
cord-017527-ylng1us2	48	40	assigned	assign	VBN
cord-017527-ylng1us2	48	41	to	to	IN
cord-017527-ylng1us2	48	42	class	class	NN
cord-017527-ylng1us2	48	43	of	of	IN
cord-017527-ylng1us2	48	44	risk	risk	NN
cord-017527-ylng1us2	48	45	4	4	CD
cord-017527-ylng1us2	48	46	.	.	.
cord-017527-ylng1us2	49	1	As	as	IN
cord-017527-ylng1us2	49	2	such	such	JJ
cord-017527-ylng1us2	49	3	,	,	,
cord-017527-ylng1us2	49	4	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	49	5	organisms	organism	NNS
cord-017527-ylng1us2	49	6	will	will	MD
cord-017527-ylng1us2	49	7	be	be	VB
cord-017527-ylng1us2	49	8	categorised	categorise	VBN
cord-017527-ylng1us2	49	9	from	from	IN
cord-017527-ylng1us2	49	10	class	class	NN
cord-017527-ylng1us2	49	11	of	of	IN
cord-017527-ylng1us2	49	12	risk	risk	NN
cord-017527-ylng1us2	49	13	2	2	CD
cord-017527-ylng1us2	49	14	to	to	IN
cord-017527-ylng1us2	49	15	class	class	NN
cord-017527-ylng1us2	49	16	of	of	IN
cord-017527-ylng1us2	49	17	risk	risk	NN
cord-017527-ylng1us2	49	18	4	4	CD
cord-017527-ylng1us2	49	19	.	.	.
cord-017527-ylng1us2	50	1	Some	some	DT
cord-017527-ylng1us2	50	2	periodically	periodically	RB
cord-017527-ylng1us2	50	3	revised	revise	VBD
cord-017527-ylng1us2	50	4	reference	reference	NN
cord-017527-ylng1us2	50	5	lists	list	NNS
cord-017527-ylng1us2	50	6	issued	issue	VBN
cord-017527-ylng1us2	50	7	by	by	IN
cord-017527-ylng1us2	50	8	international	international	JJ
cord-017527-ylng1us2	50	9	and	and	CC
cord-017527-ylng1us2	50	10	national	national	JJ
cord-017527-ylng1us2	50	11	authorities	authority	NNS
cord-017527-ylng1us2	50	12	or	or	CC
cord-017527-ylng1us2	50	13	advisory	advisory	JJ
cord-017527-ylng1us2	50	14	committees	committee	NNS
cord-017527-ylng1us2	50	15	classify	classify	VB
cord-017527-ylng1us2	50	16	natural	natural	JJ
cord-017527-ylng1us2	50	17	biological	biological	JJ
cord-017527-ylng1us2	50	18	agents	agent	NNS
cord-017527-ylng1us2	50	19	(	(	-LRB-
cord-017527-ylng1us2	50	20	not	not	RB
cord-017527-ylng1us2	50	21	genetically	genetically	RB
cord-017527-ylng1us2	50	22	modified	modify	VBN
cord-017527-ylng1us2	50	23	)	)	-RRB-
cord-017527-ylng1us2	50	24	into	into	IN
cord-017527-ylng1us2	50	25	risk	risk	NN
cord-017527-ylng1us2	50	26	groups	group	NNS
cord-017527-ylng1us2	50	27	or	or	CC
cord-017527-ylng1us2	50	28	assign	assign	VB
cord-017527-ylng1us2	50	29	the	the	DT
cord-017527-ylng1us2	50	30	biosafety	biosafety	NN
cord-017527-ylng1us2	50	31	level	level	NN
cord-017527-ylng1us2	50	32	under	under	IN
cord-017527-ylng1us2	50	33	which	which	WDT
cord-017527-ylng1us2	50	34	these	these	DT
cord-017527-ylng1us2	50	35	should	should	MD
cord-017527-ylng1us2	50	36	be	be	VB
cord-017527-ylng1us2	50	37	manipulated	manipulate	VBN
cord-017527-ylng1us2	50	38	(	(	-LRB-
cord-017527-ylng1us2	50	39	In	in	IN
cord-017527-ylng1us2	50	40	the	the	DT
cord-017527-ylng1us2	50	41	second	second	JJ
cord-017527-ylng1us2	50	42	step	step	NN
cord-017527-ylng1us2	50	43	(	(	-LRB-
cord-017527-ylng1us2	50	44	2	2	CD
cord-017527-ylng1us2	50	45	)	)	-RRB-
cord-017527-ylng1us2	50	46	,	,	,
cord-017527-ylng1us2	50	47	the	the	DT
cord-017527-ylng1us2	50	48	magnitude	magnitude	NN
cord-017527-ylng1us2	50	49	of	of	IN
cord-017527-ylng1us2	50	50	the	the	DT
cord-017527-ylng1us2	50	51	identified	identify	VBN
cord-017527-ylng1us2	50	52	negative	negative	JJ
cord-017527-ylng1us2	50	53	effects	effect	NNS
cord-017527-ylng1us2	50	54	such	such	JJ
cord-017527-ylng1us2	50	55	as	as	IN
cord-017527-ylng1us2	50	56	human	human	JJ
cord-017527-ylng1us2	50	57	diseases	disease	NNS
cord-017527-ylng1us2	50	58	,	,	,
cord-017527-ylng1us2	50	59	including	include	VBG
cord-017527-ylng1us2	50	60	allergenic	allergenic	JJ
cord-017527-ylng1us2	50	61	or	or	CC
cord-017527-ylng1us2	50	62	toxic	toxic	JJ
cord-017527-ylng1us2	50	63	effects	effect	NNS
cord-017527-ylng1us2	50	64	or	or	CC
cord-017527-ylng1us2	50	65	the	the	DT
cord-017527-ylng1us2	50	66	transfer	transfer	NN
cord-017527-ylng1us2	50	67	of	of	IN
cord-017527-ylng1us2	50	68	genetic	genetic	JJ
cord-017527-ylng1us2	50	69	material	material	NN
cord-017527-ylng1us2	50	70	to	to	IN
cord-017527-ylng1us2	50	71	other	other	JJ
cord-017527-ylng1us2	50	72	organisms	organism	NNS
cord-017527-ylng1us2	50	73	are	be	VBP
cord-017527-ylng1us2	50	74	characterized	characterize	VBN
cord-017527-ylng1us2	50	75	.	.	.
cord-017527-ylng1us2	51	1	In	in	IN
cord-017527-ylng1us2	51	2	a	a	DT
cord-017527-ylng1us2	51	3	third	third	JJ
cord-017527-ylng1us2	51	4	step	step	NN
cord-017527-ylng1us2	51	5	(	(	-LRB-
cord-017527-ylng1us2	51	6	3	3	CD
cord-017527-ylng1us2	51	7	)	)	-RRB-
cord-017527-ylng1us2	51	8	,	,	,
cord-017527-ylng1us2	51	9	an	an	DT
cord-017527-ylng1us2	51	10	assessment	assessment	NN
cord-017527-ylng1us2	51	11	is	be	VBZ
cord-017527-ylng1us2	51	12	performed	perform	VBN
cord-017527-ylng1us2	51	13	of	of	IN
cord-017527-ylng1us2	51	14	the	the	DT
cord-017527-ylng1us2	51	15	exposure	exposure	NN
cord-017527-ylng1us2	51	16	of	of	IN
cord-017527-ylng1us2	51	17	the	the	DT
cord-017527-ylng1us2	51	18	laboratory	laboratory	NN
cord-017527-ylng1us2	51	19	worker	worker	NN
cord-017527-ylng1us2	51	20	,	,	,
cord-017527-ylng1us2	51	21	the	the	DT
cord-017527-ylng1us2	51	22	population	population	NN
cord-017527-ylng1us2	51	23	and/or	and/or	CC
cord-017527-ylng1us2	51	24	the	the	DT
cord-017527-ylng1us2	51	25	environment	environment	NN
cord-017527-ylng1us2	51	26	to	to	IN
cord-017527-ylng1us2	51	27	the	the	DT
cord-017527-ylng1us2	51	28	considered	consider	VBN
cord-017527-ylng1us2	51	29	organism	organism	NN
cord-017527-ylng1us2	51	30	and	and	CC
cord-017527-ylng1us2	51	31	the	the	DT
cord-017527-ylng1us2	51	32	consequences	consequence	NNS
cord-017527-ylng1us2	51	33	of	of	IN
cord-017527-ylng1us2	51	34	each	each	DT
cord-017527-ylng1us2	51	35	negative	negative	JJ
cord-017527-ylng1us2	51	36	effect	effect	NN
cord-017527-ylng1us2	51	37	should	should	MD
cord-017527-ylng1us2	51	38	it	-PRON-	PRP
cord-017527-ylng1us2	51	39	occur	occur	VB
cord-017527-ylng1us2	51	40	.	.	.
cord-017527-ylng1us2	52	1	In	in	IN
cord-017527-ylng1us2	52	2	the	the	DT
cord-017527-ylng1us2	52	3	fourth	fourth	JJ
cord-017527-ylng1us2	52	4	step	step	NN
cord-017527-ylng1us2	52	5	(	(	-LRB-
cord-017527-ylng1us2	52	6	4	4	CD
cord-017527-ylng1us2	52	7	)	)	-RRB-
cord-017527-ylng1us2	52	8	,	,	,
cord-017527-ylng1us2	52	9	a	a	DT
cord-017527-ylng1us2	52	10	characterization	characterization	NN
cord-017527-ylng1us2	52	11	of	of	IN
cord-017527-ylng1us2	52	12	the	the	DT
cord-017527-ylng1us2	52	13	risk	risk	NN
cord-017527-ylng1us2	52	14	is	be	VBZ
cord-017527-ylng1us2	52	15	performed	perform	VBN
cord-017527-ylng1us2	52	16	resulting	result	VBG
cord-017527-ylng1us2	52	17	in	in	IN
cord-017527-ylng1us2	52	18	the	the	DT
cord-017527-ylng1us2	52	19	assignment	assignment	NN
cord-017527-ylng1us2	52	20	of	of	IN
cord-017527-ylng1us2	52	21	the	the	DT
cord-017527-ylng1us2	52	22	risk	risk	NN
cord-017527-ylng1us2	52	23	level	level	NN
cord-017527-ylng1us2	52	24	associated	associate	VBN
cord-017527-ylng1us2	52	25	with	with	IN
cord-017527-ylng1us2	52	26	the	the	DT
cord-017527-ylng1us2	52	27	contained	contain	VBN
cord-017527-ylng1us2	52	28	use	use	NN
cord-017527-ylng1us2	52	29	involving	involve	VBG
cord-017527-ylng1us2	52	30	the	the	DT
cord-017527-ylng1us2	52	31	use	use	NN
cord-017527-ylng1us2	52	32	of	of	IN
cord-017527-ylng1us2	52	33	the	the	DT
cord-017527-ylng1us2	52	34	organism(s	organism(s	NNP
cord-017527-ylng1us2	52	35	)	)	-RRB-
cord-017527-ylng1us2	52	36	.	.	.
cord-017527-ylng1us2	53	1	On	on	IN
cord-017527-ylng1us2	53	2	this	this	DT
cord-017527-ylng1us2	53	3	basis	basis	NN
cord-017527-ylng1us2	53	4	,	,	,
cord-017527-ylng1us2	53	5	the	the	DT
cord-017527-ylng1us2	53	6	containment	containment	NN
cord-017527-ylng1us2	53	7	measures	measure	NNS
cord-017527-ylng1us2	53	8	and	and	CC
cord-017527-ylng1us2	53	9	other	other	JJ
cord-017527-ylng1us2	53	10	protection	protection	NN
cord-017527-ylng1us2	53	11	measures	measure	NNS
cord-017527-ylng1us2	53	12	(	(	-LRB-
cord-017527-ylng1us2	53	13	e.g.	e.g.	DT
cord-017527-ylng1us2	53	14	safe	safe	JJ
cord-017527-ylng1us2	53	15	work	work	NN
cord-017527-ylng1us2	53	16	practices	practice	NNS
cord-017527-ylng1us2	53	17	,	,	,
cord-017527-ylng1us2	53	18	safety	safety	NN
cord-017527-ylng1us2	53	19	equipment	equipment	NN
cord-017527-ylng1us2	53	20	and	and	CC
cord-017527-ylng1us2	53	21	biological	biological	JJ
cord-017527-ylng1us2	53	22	waste	waste	NN
cord-017527-ylng1us2	53	23	management	management	NN
cord-017527-ylng1us2	53	24	)	)	-RRB-
cord-017527-ylng1us2	53	25	to	to	TO
cord-017527-ylng1us2	53	26	be	be	VB
cord-017527-ylng1us2	53	27	adopted	adopt	VBN
cord-017527-ylng1us2	53	28	are	be	VBP
cord-017527-ylng1us2	53	29	determined	determine	VBN
cord-017527-ylng1us2	53	30	.	.	.
cord-017527-ylng1us2	54	1	There	there	EX
cord-017527-ylng1us2	54	2	are	be	VBP
cord-017527-ylng1us2	54	3	four	four	CD
cord-017527-ylng1us2	54	4	levels	level	NNS
cord-017527-ylng1us2	54	5	Fig	fig	NN
cord-017527-ylng1us2	54	6	.	.	.
cord-017527-ylng1us2	55	1	22	22	CD
cord-017527-ylng1us2	56	1	.1	.1	.
cord-017527-ylng1us2	57	1	Flow	flow	NN
cord-017527-ylng1us2	57	2	diagram	diagram	NN
cord-017527-ylng1us2	57	3	summarizing	summarize	VBG
cord-017527-ylng1us2	57	4	the	the	DT
cord-017527-ylng1us2	57	5	Biorisk	Biorisk	NNP
cord-017527-ylng1us2	57	6	assessment	assessment	NN
cord-017527-ylng1us2	57	7	and	and	CC
cord-017527-ylng1us2	57	8	management	management	NN
cord-017527-ylng1us2	57	9	methodology	methodology	NN
cord-017527-ylng1us2	57	10	of	of	IN
cord-017527-ylng1us2	57	11	risk	risk	NN
cord-017527-ylng1us2	57	12	to	to	TO
cord-017527-ylng1us2	57	13	which	which	WDT
cord-017527-ylng1us2	57	14	contained	contain	VBD
cord-017527-ylng1us2	57	15	uses	use	NNS
cord-017527-ylng1us2	57	16	can	can	MD
cord-017527-ylng1us2	57	17	be	be	VB
cord-017527-ylng1us2	57	18	assigned	assign	VBN
cord-017527-ylng1us2	57	19	,	,	,
cord-017527-ylng1us2	57	20	with	with	IN
cord-017527-ylng1us2	57	21	level	level	NN
cord-017527-ylng1us2	57	22	of	of	IN
cord-017527-ylng1us2	57	23	risk	risk	NN
cord-017527-ylng1us2	57	24	increasing	increase	VBG
cord-017527-ylng1us2	57	25	from	from	IN
cord-017527-ylng1us2	57	26	1	1	CD
cord-017527-ylng1us2	57	27	to	to	IN
cord-017527-ylng1us2	57	28	4	4	CD
cord-017527-ylng1us2	57	29	.	.	.
cord-017527-ylng1us2	58	1	The	the	DT
cord-017527-ylng1us2	58	2	final	final	JJ
cord-017527-ylng1us2	58	3	step	step	NN
cord-017527-ylng1us2	58	4	consists	consist	VBZ
cord-017527-ylng1us2	58	5	in	in	IN
cord-017527-ylng1us2	58	6	definitively	definitively	RB
cord-017527-ylng1us2	58	7	classifying	classify	VBG
cord-017527-ylng1us2	58	8	the	the	DT
cord-017527-ylng1us2	58	9	contained	contain	VBN
cord-017527-ylng1us2	58	10	use	use	NN
cord-017527-ylng1us2	58	11	activity	activity	NN
cord-017527-ylng1us2	58	12	by	by	IN
cord-017527-ylng1us2	58	13	conducting	conduct	VBG
cord-017527-ylng1us2	58	14	a	a	DT
cord-017527-ylng1us2	58	15	re	re	NN
cord-017527-ylng1us2	58	16	-	-	NN
cord-017527-ylng1us2	58	17	assessment	assessment	NN
cord-017527-ylng1us2	58	18	of	of	IN
cord-017527-ylng1us2	58	19	the	the	DT
cord-017527-ylng1us2	58	20	whole	whole	JJ
cord-017527-ylng1us2	58	21	procedure	procedure	NN
cord-017527-ylng1us2	58	22	before	before	IN
cord-017527-ylng1us2	58	23	starting	start	VBG
cord-017527-ylng1us2	58	24	the	the	DT
cord-017527-ylng1us2	58	25	research	research	NN
cord-017527-ylng1us2	58	26	,	,	,
cord-017527-ylng1us2	58	27	diagnosis	diagnosis	NN
cord-017527-ylng1us2	58	28	or	or	CC
cord-017527-ylng1us2	58	29	production	production	NN
cord-017527-ylng1us2	58	30	activity	activity	NN
cord-017527-ylng1us2	58	31	.	.	.
cord-017527-ylng1us2	59	1	In	in	IN
cord-017527-ylng1us2	59	2	this	this	DT
cord-017527-ylng1us2	59	3	chapter	chapter	NN
cord-017527-ylng1us2	59	4	,	,	,
cord-017527-ylng1us2	59	5	the	the	DT
cord-017527-ylng1us2	59	6	risk	risk	NN
cord-017527-ylng1us2	59	7	assessment	assessment	NN
cord-017527-ylng1us2	59	8	methodology	methodology	NN
cord-017527-ylng1us2	59	9	applied	apply	VBN
cord-017527-ylng1us2	59	10	to	to	IN
cord-017527-ylng1us2	59	11	animal	animal	NN
cord-017527-ylng1us2	59	12	cell	cell	NN
cord-017527-ylng1us2	59	13	cultures	culture	NNS
cord-017527-ylng1us2	59	14	is	be	VBZ
cord-017527-ylng1us2	59	15	developed	develop	VBN
cord-017527-ylng1us2	59	16	and	and	CC
cord-017527-ylng1us2	59	17	illustrated	illustrate	VBN
cord-017527-ylng1us2	59	18	by	by	IN
cord-017527-ylng1us2	59	19	examples	example	NNS
cord-017527-ylng1us2	59	20	.	.	.
cord-017527-ylng1us2	60	1	It	-PRON-	PRP
cord-017527-ylng1us2	60	2	is	be	VBZ
cord-017527-ylng1us2	60	3	important	important	JJ
cord-017527-ylng1us2	60	4	to	to	TO
cord-017527-ylng1us2	60	5	mention	mention	VB
cord-017527-ylng1us2	60	6	that	that	IN
cord-017527-ylng1us2	60	7	such	such	PDT
cord-017527-ylng1us2	60	8	a	a	DT
cord-017527-ylng1us2	60	9	risk	risk	NN
cord-017527-ylng1us2	60	10	assessment	assessment	NN
cord-017527-ylng1us2	60	11	is	be	VBZ
cord-017527-ylng1us2	60	12	always	always	RB
cord-017527-ylng1us2	60	13	performed	perform	VBN
cord-017527-ylng1us2	60	14	on	on	IN
cord-017527-ylng1us2	60	15	a	a	DT
cord-017527-ylng1us2	60	16	case	case	NN
cord-017527-ylng1us2	60	17	by	by	IN
cord-017527-ylng1us2	60	18	case	case	NN
cord-017527-ylng1us2	60	19	basis	basis	NN
cord-017527-ylng1us2	60	20	by	by	IN
cord-017527-ylng1us2	60	21	the	the	DT
cord-017527-ylng1us2	60	22	scientist	scientist	NN
cord-017527-ylng1us2	60	23	(	(	-LRB-
cord-017527-ylng1us2	60	24	s	s	NN
cord-017527-ylng1us2	60	25	)	)	-RRB-
cord-017527-ylng1us2	60	26	responsible	responsible	JJ
cord-017527-ylng1us2	60	27	for	for	IN
cord-017527-ylng1us2	60	28	the	the	DT
cord-017527-ylng1us2	60	29	activity	activity	NN
cord-017527-ylng1us2	60	30	and	and	CC
cord-017527-ylng1us2	60	31	the	the	DT
cord-017527-ylng1us2	60	32	biosafety	biosafety	NN
cord-017527-ylng1us2	60	33	officer	officer	NN
cord-017527-ylng1us2	60	34	(	(	-LRB-
cord-017527-ylng1us2	60	35	or	or	CC
cord-017527-ylng1us2	60	36	biosafety	biosafety	NN
cord-017527-ylng1us2	60	37	professional	professional	JJ
cord-017527-ylng1us2	60	38	)	)	-RRB-
cord-017527-ylng1us2	60	39	in	in	IN
cord-017527-ylng1us2	60	40	compliance	compliance	NN
cord-017527-ylng1us2	60	41	with	with	IN
cord-017527-ylng1us2	60	42	local	local	JJ
cord-017527-ylng1us2	60	43	guidance	guidance	NN
cord-017527-ylng1us2	60	44	and	and	CC
cord-017527-ylng1us2	60	45	regulatory	regulatory	JJ
cord-017527-ylng1us2	60	46	requirements	requirement	NNS
cord-017527-ylng1us2	60	47	.	.	.
cord-017527-ylng1us2	61	1	The	the	DT
cord-017527-ylng1us2	61	2	risk	risk	NN
cord-017527-ylng1us2	61	3	assessment	assessment	NN
cord-017527-ylng1us2	61	4	applied	apply	VBN
cord-017527-ylng1us2	61	5	to	to	IN
cord-017527-ylng1us2	61	6	animal	animal	NN
cord-017527-ylng1us2	61	7	cell	cell	NN
cord-017527-ylng1us2	61	8	cultures	culture	NNS
cord-017527-ylng1us2	61	9	relies	rely	VBZ
cord-017527-ylng1us2	61	10	on	on	IN
cord-017527-ylng1us2	61	11	a	a	DT
cord-017527-ylng1us2	61	12	thorough	thorough	JJ
cord-017527-ylng1us2	61	13	evaluation	evaluation	NN
cord-017527-ylng1us2	61	14	of	of	IN
cord-017527-ylng1us2	61	15	both	both	CC
cord-017527-ylng1us2	61	16	the	the	DT
cord-017527-ylng1us2	61	17	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	61	18	properties	property	NNS
cord-017527-ylng1us2	61	19	of	of	IN
cord-017527-ylng1us2	61	20	the	the	DT
cord-017527-ylng1us2	61	21	cell	cell	NN
cord-017527-ylng1us2	61	22	culture	culture	NN
cord-017527-ylng1us2	61	23	-including	-including	NN
cord-017527-ylng1us2	62	1	subsequent	subsequent	JJ
cord-017527-ylng1us2	62	2	properties	property	NNS
cord-017527-ylng1us2	62	3	acquired	acquire	VBD
cord-017527-ylng1us2	62	4	as	as	IN
cord-017527-ylng1us2	62	5	a	a	DT
cord-017527-ylng1us2	62	6	result	result	NN
cord-017527-ylng1us2	62	7	of	of	IN
cord-017527-ylng1us2	62	8	genetic	genetic	JJ
cord-017527-ylng1us2	62	9	modification(s	modification(s	NNP
cord-017527-ylng1us2	62	10	)	)	-RRB-
cord-017527-ylng1us2	63	1	-and	-and	:
cord-017527-ylng1us2	63	2	the	the	DT
cord-017527-ylng1us2	63	3	possibility	possibility	NN
cord-017527-ylng1us2	63	4	that	that	IN
cord-017527-ylng1us2	63	5	the	the	DT
cord-017527-ylng1us2	63	6	cell	cell	NN
cord-017527-ylng1us2	63	7	culture	culture	NN
cord-017527-ylng1us2	63	8	may	may	MD
cord-017527-ylng1us2	63	9	inadvertently	inadvertently	RB
cord-017527-ylng1us2	63	10	be	be	VB
cord-017527-ylng1us2	63	11	contaminated	contaminate	VBN
cord-017527-ylng1us2	63	12	or	or	CC
cord-017527-ylng1us2	63	13	deliberately	deliberately	RB
cord-017527-ylng1us2	63	14	infected	infect	VBN
cord-017527-ylng1us2	63	15	with	with	IN
cord-017527-ylng1us2	63	16	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	63	17	micro	micro	NNS
cord-017527-ylng1us2	63	18	-	-	HYPH
cord-017527-ylng1us2	63	19	organisms	organism	NNS
cord-017527-ylng1us2	63	20	.	.	.
cord-017527-ylng1us2	64	1	It	-PRON-	PRP
cord-017527-ylng1us2	64	2	also	also	RB
cord-017527-ylng1us2	64	3	includes	include	VBZ
cord-017527-ylng1us2	64	4	an	an	DT
cord-017527-ylng1us2	64	5	exposure	exposure	NN
cord-017527-ylng1us2	64	6	assessment	assessment	NN
cord-017527-ylng1us2	64	7	which	which	WDT
cord-017527-ylng1us2	64	8	means	mean	VBZ
cord-017527-ylng1us2	64	9	that	that	IN
cord-017527-ylng1us2	64	10	the	the	DT
cord-017527-ylng1us2	64	11	type	type	NN
cord-017527-ylng1us2	64	12	of	of	IN
cord-017527-ylng1us2	64	13	manipulation	manipulation	NN
cord-017527-ylng1us2	64	14	carried	carry	VBN
cord-017527-ylng1us2	64	15	out	out	RP
cord-017527-ylng1us2	64	16	with	with	IN
cord-017527-ylng1us2	64	17	the	the	DT
cord-017527-ylng1us2	64	18	cell	cell	NN
cord-017527-ylng1us2	64	19	cultures	culture	NNS
cord-017527-ylng1us2	64	20	is	be	VBZ
cord-017527-ylng1us2	64	21	taken	take	VBN
cord-017527-ylng1us2	64	22	into	into	IN
cord-017527-ylng1us2	64	23	account	account	NN
cord-017527-ylng1us2	64	24	.	.	.
cord-017527-ylng1us2	65	1	The	the	DT
cord-017527-ylng1us2	65	2	assessment	assessment	NN
cord-017527-ylng1us2	65	3	of	of	IN
cord-017527-ylng1us2	65	4	cell	cell	NN
cord-017527-ylng1us2	65	5	cultures	culture	NNS
cord-017527-ylng1us2	65	6	harbouring	harbour	VBG
cord-017527-ylng1us2	65	7	pathogens	pathogen	NNS
cord-017527-ylng1us2	65	8	follows	follow	VBZ
cord-017527-ylng1us2	65	9	the	the	DT
cord-017527-ylng1us2	65	10	same	same	JJ
cord-017527-ylng1us2	65	11	principles	principle	NNS
cord-017527-ylng1us2	65	12	as	as	IN
cord-017527-ylng1us2	65	13	the	the	DT
cord-017527-ylng1us2	65	14	assessment	assessment	NN
cord-017527-ylng1us2	65	15	of	of	IN
cord-017527-ylng1us2	65	16	the	the	DT
cord-017527-ylng1us2	65	17	pathogens	pathogen	NNS
cord-017527-ylng1us2	65	18	itself	-PRON-	PRP
cord-017527-ylng1us2	65	19	.	.	.
cord-017527-ylng1us2	66	1	First	first	RB
cord-017527-ylng1us2	66	2	,	,	,
cord-017527-ylng1us2	66	3	the	the	DT
cord-017527-ylng1us2	66	4	main	main	JJ
cord-017527-ylng1us2	66	5	organism	organism	NN
cord-017527-ylng1us2	66	6	characteristics	characteristic	NNS
cord-017527-ylng1us2	66	7	(	(	-LRB-
cord-017527-ylng1us2	66	8	a	a	DT
cord-017527-ylng1us2	66	9	comprehensive	comprehensive	JJ
cord-017527-ylng1us2	66	10	description	description	NN
cord-017527-ylng1us2	66	11	of	of	IN
cord-017527-ylng1us2	66	12	the	the	DT
cord-017527-ylng1us2	66	13	pathogen	pathogen	NN
cord-017527-ylng1us2	66	14	)	)	-RRB-
cord-017527-ylng1us2	66	15	is	be	VBZ
cord-017527-ylng1us2	66	16	considered	consider	VBN
cord-017527-ylng1us2	66	17	by	by	IN
cord-017527-ylng1us2	66	18	taking	take	VBG
cord-017527-ylng1us2	66	19	into	into	IN
cord-017527-ylng1us2	66	20	account	account	NN
cord-017527-ylng1us2	66	21	the	the	DT
cord-017527-ylng1us2	66	22	following	follow	VBG
cord-017527-ylng1us2	66	23	parameters	parameter	NNS
cord-017527-ylng1us2	66	24	(	(	-LRB-
cord-017527-ylng1us2	66	25	not	not	RB
cord-017527-ylng1us2	66	26	by	by	IN
cord-017527-ylng1us2	66	27	order	order	NN
cord-017527-ylng1us2	66	28	of	of	IN
cord-017527-ylng1us2	66	29	importance	importance	NN
cord-017527-ylng1us2	66	30	)	)	-RRB-
cord-017527-ylng1us2	66	31	:	:	:
cord-017527-ylng1us2	67	1	(	(	-LRB-
cord-017527-ylng1us2	67	2	1	1	LS
cord-017527-ylng1us2	67	3	)	)	-RRB-
cord-017527-ylng1us2	67	4	the	the	DT
cord-017527-ylng1us2	67	5	pathogenicity	pathogenicity	NN
cord-017527-ylng1us2	67	6	and	and	CC
cord-017527-ylng1us2	67	7	,	,	,
cord-017527-ylng1us2	67	8	when	when	WRB
cord-017527-ylng1us2	67	9	available	available	JJ
cord-017527-ylng1us2	67	10	,	,	,
cord-017527-ylng1us2	67	11	the	the	DT
cord-017527-ylng1us2	67	12	infectious	infectious	JJ
cord-017527-ylng1us2	67	13	dose	dose	NN
cord-017527-ylng1us2	67	14	(	(	-LRB-
cord-017527-ylng1us2	67	15	2	2	LS
cord-017527-ylng1us2	67	16	)	)	-RRB-
cord-017527-ylng1us2	67	17	the	the	DT
cord-017527-ylng1us2	67	18	mode	mode	NN
cord-017527-ylng1us2	67	19	of	of	IN
cord-017527-ylng1us2	67	20	transmission	transmission	NN
cord-017527-ylng1us2	67	21	,	,	,
cord-017527-ylng1us2	67	22	(	(	-LRB-
cord-017527-ylng1us2	67	23	3	3	LS
cord-017527-ylng1us2	67	24	)	)	-RRB-
cord-017527-ylng1us2	67	25	the	the	DT
cord-017527-ylng1us2	67	26	host	host	NN
cord-017527-ylng1us2	67	27	range	range	NN
cord-017527-ylng1us2	67	28	,	,	,
cord-017527-ylng1us2	67	29	(	(	-LRB-
cord-017527-ylng1us2	67	30	4	4	LS
cord-017527-ylng1us2	67	31	)	)	-RRB-
cord-017527-ylng1us2	67	32	the	the	DT
cord-017527-ylng1us2	67	33	epidemiology	epidemiology	NN
cord-017527-ylng1us2	67	34	(	(	-LRB-
cord-017527-ylng1us2	67	35	assignment	assignment	NN
cord-017527-ylng1us2	67	36	of	of	IN
cord-017527-ylng1us2	67	37	appropriate	appropriate	JJ
cord-017527-ylng1us2	67	38	risk	risk	NN
cord-017527-ylng1us2	67	39	group	group	NN
cord-017527-ylng1us2	67	40	may	may	MD
cord-017527-ylng1us2	67	41	depend	depend	VB
cord-017527-ylng1us2	67	42	on	on	IN
cord-017527-ylng1us2	67	43	the	the	DT
cord-017527-ylng1us2	67	44	geographic	geographic	JJ
cord-017527-ylng1us2	67	45	localisation	localisation	NN
cord-017527-ylng1us2	67	46	)	)	-RRB-
cord-017527-ylng1us2	67	47	,	,	,
cord-017527-ylng1us2	67	48	possible	possible	JJ
cord-017527-ylng1us2	67	49	reservoir	reservoir	NN
cord-017527-ylng1us2	67	50	and	and	CC
cord-017527-ylng1us2	67	51	vector(s	vector(s	NN
cord-017527-ylng1us2	67	52	)	)	-RRB-
cord-017527-ylng1us2	67	53	,	,	,
cord-017527-ylng1us2	67	54	and	and	CC
cord-017527-ylng1us2	67	55	the	the	DT
cord-017527-ylng1us2	67	56	ability	ability	NN
cord-017527-ylng1us2	67	57	to	to	TO
cord-017527-ylng1us2	67	58	zoonosis	zoonosis	VB
cord-017527-ylng1us2	67	59	(	(	-LRB-
cord-017527-ylng1us2	67	60	5	5	LS
cord-017527-ylng1us2	67	61	)	)	-RRB-
cord-017527-ylng1us2	67	62	the	the	DT
cord-017527-ylng1us2	67	63	stability	stability	NN
cord-017527-ylng1us2	67	64	and	and	CC
cord-017527-ylng1us2	67	65	the	the	DT
cord-017527-ylng1us2	67	66	persistence	persistence	NN
cord-017527-ylng1us2	67	67	of	of	IN
cord-017527-ylng1us2	67	68	the	the	DT
cord-017527-ylng1us2	67	69	organism	organism	NN
cord-017527-ylng1us2	67	70	in	in	IN
cord-017527-ylng1us2	67	71	the	the	DT
cord-017527-ylng1us2	67	72	environment	environment	NN
cord-017527-ylng1us2	67	73	(	(	-LRB-
cord-017527-ylng1us2	67	74	i.e.	i.e.	FW
cord-017527-ylng1us2	67	75	survival	survival	NN
cord-017527-ylng1us2	67	76	outside	outside	IN
cord-017527-ylng1us2	67	77	the	the	DT
cord-017527-ylng1us2	67	78	host	host	NN
cord-017527-ylng1us2	67	79	)	)	-RRB-
cord-017527-ylng1us2	67	80	.	.	.
cord-017527-ylng1us2	68	1	In	in	IN
cord-017527-ylng1us2	68	2	addition	addition	NN
cord-017527-ylng1us2	68	3	,	,	,
cord-017527-ylng1us2	68	4	information	information	NN
cord-017527-ylng1us2	68	5	related	relate	VBN
cord-017527-ylng1us2	68	6	to	to	IN
cord-017527-ylng1us2	68	7	the	the	DT
cord-017527-ylng1us2	68	8	physicochemical	physicochemical	JJ
cord-017527-ylng1us2	68	9	properties	property	NNS
cord-017527-ylng1us2	68	10	of	of	IN
cord-017527-ylng1us2	68	11	the	the	DT
cord-017527-ylng1us2	68	12	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	68	13	organism	organism	NN
cord-017527-ylng1us2	68	14	is	be	VBZ
cord-017527-ylng1us2	68	15	considered	consider	VBN
cord-017527-ylng1us2	68	16	such	such	JJ
cord-017527-ylng1us2	68	17	as	as	IN
cord-017527-ylng1us2	68	18	:	:	:
cord-017527-ylng1us2	68	19	(	(	-LRB-
cord-017527-ylng1us2	68	20	1	1	LS
cord-017527-ylng1us2	68	21	)	)	-RRB-
cord-017527-ylng1us2	68	22	susceptibility	susceptibility	NN
cord-017527-ylng1us2	68	23	to	to	IN
cord-017527-ylng1us2	68	24	disinfectants	disinfectant	NNS
cord-017527-ylng1us2	68	25	,	,	,
cord-017527-ylng1us2	68	26	(	(	-LRB-
cord-017527-ylng1us2	68	27	2	2	LS
cord-017527-ylng1us2	68	28	)	)	-RRB-
cord-017527-ylng1us2	68	29	physical	physical	JJ
cord-017527-ylng1us2	68	30	inactivation	inactivation	NN
cord-017527-ylng1us2	68	31	and	and	CC
cord-017527-ylng1us2	68	32	(	(	-LRB-
cord-017527-ylng1us2	68	33	3	3	LS
cord-017527-ylng1us2	68	34	)	)	-RRB-
cord-017527-ylng1us2	68	35	drug	drug	NN
cord-017527-ylng1us2	68	36	susceptibility	susceptibility	NN
cord-017527-ylng1us2	68	37	(	(	-LRB-
cord-017527-ylng1us2	68	38	e.g.	e.g.	IN
cord-017527-ylng1us2	68	39	sensitivity	sensitivity	NN
cord-017527-ylng1us2	68	40	and	and	CC
cord-017527-ylng1us2	68	41	known	know	VBN
cord-017527-ylng1us2	68	42	resistance	resistance	NN
cord-017527-ylng1us2	68	43	to	to	IN
cord-017527-ylng1us2	68	44	antibiotics	antibiotic	NNS
cord-017527-ylng1us2	68	45	or	or	CC
cord-017527-ylng1us2	68	46	antiviral	antiviral	JJ
cord-017527-ylng1us2	68	47	compounds	compound	NNS
cord-017527-ylng1us2	68	48	)	)	-RRB-
cord-017527-ylng1us2	68	49	.	.	.
cord-017527-ylng1us2	69	1	Finally	finally	RB
cord-017527-ylng1us2	69	2	,	,	,
cord-017527-ylng1us2	69	3	aspects	aspect	NNS
cord-017527-ylng1us2	69	4	related	relate	VBN
cord-017527-ylng1us2	69	5	to	to	IN
cord-017527-ylng1us2	69	6	the	the	DT
cord-017527-ylng1us2	69	7	disease	disease	NN
cord-017527-ylng1us2	69	8	caused	cause	VBN
cord-017527-ylng1us2	69	9	by	by	IN
cord-017527-ylng1us2	69	10	the	the	DT
cord-017527-ylng1us2	69	11	pathogen	pathogen	NN
cord-017527-ylng1us2	69	12	are	be	VBP
cord-017527-ylng1us2	69	13	also	also	RB
cord-017527-ylng1us2	69	14	to	to	TO
cord-017527-ylng1us2	69	15	be	be	VB
cord-017527-ylng1us2	69	16	taken	take	VBN
cord-017527-ylng1us2	69	17	into	into	IN
cord-017527-ylng1us2	69	18	consideration	consideration	NN
cord-017527-ylng1us2	69	19	.	.	.
cord-017527-ylng1us2	70	1	This	this	DT
cord-017527-ylng1us2	70	2	includes	include	VBZ
cord-017527-ylng1us2	70	3	(	(	-LRB-
cord-017527-ylng1us2	70	4	1	1	LS
cord-017527-ylng1us2	70	5	)	)	-RRB-
cord-017527-ylng1us2	70	6	the	the	DT
cord-017527-ylng1us2	70	7	availability	availability	NN
cord-017527-ylng1us2	70	8	of	of	IN
cord-017527-ylng1us2	70	9	an	an	DT
cord-017527-ylng1us2	70	10	effective	effective	JJ
cord-017527-ylng1us2	70	11	prophylaxis	prophylaxis	NN
cord-017527-ylng1us2	70	12	,	,	,
cord-017527-ylng1us2	70	13	(	(	-LRB-
cord-017527-ylng1us2	70	14	2	2	LS
cord-017527-ylng1us2	70	15	)	)	-RRB-
cord-017527-ylng1us2	70	16	the	the	DT
cord-017527-ylng1us2	70	17	availability	availability	NN
cord-017527-ylng1us2	70	18	of	of	IN
cord-017527-ylng1us2	70	19	an	an	DT
cord-017527-ylng1us2	70	20	efficient	efficient	JJ
cord-017527-ylng1us2	70	21	therapy	therapy	NN
cord-017527-ylng1us2	70	22	and	and	CC
cord-017527-ylng1us2	70	23	(	(	-LRB-
cord-017527-ylng1us2	70	24	3	3	LS
cord-017527-ylng1us2	70	25	)	)	-RRB-
cord-017527-ylng1us2	70	26	any	any	DT
cord-017527-ylng1us2	70	27	reported	report	VBN
cord-017527-ylng1us2	70	28	case	case	NN
cord-017527-ylng1us2	70	29	of	of	IN
cord-017527-ylng1us2	70	30	laboratory	laboratory	NN
cord-017527-ylng1us2	70	31	-	-	HYPH
cord-017527-ylng1us2	70	32	acquired	acquire	VBN
cord-017527-ylng1us2	70	33	infection	infection	NN
cord-017527-ylng1us2	70	34	(	(	-LRB-
cord-017527-ylng1us2	70	35	s	s	NN
cord-017527-ylng1us2	70	36	)	)	-RRB-
cord-017527-ylng1us2	70	37	(	(	-LRB-
cord-017527-ylng1us2	70	38	LAIs	LAIs	NNP
cord-017527-ylng1us2	70	39	)	)	-RRB-
cord-017527-ylng1us2	70	40	.	.	.
cord-017527-ylng1us2	71	1	Although	although	IN
cord-017527-ylng1us2	71	2	underestimated	underestimate	VBN
cord-017527-ylng1us2	71	3	,	,	,
cord-017527-ylng1us2	71	4	many	many	JJ
cord-017527-ylng1us2	71	5	cases	case	NNS
cord-017527-ylng1us2	71	6	of	of	IN
cord-017527-ylng1us2	71	7	LAIs	lai	NNS
cord-017527-ylng1us2	71	8	related	relate	VBN
cord-017527-ylng1us2	71	9	to	to	IN
cord-017527-ylng1us2	71	10	the	the	DT
cord-017527-ylng1us2	71	11	handling	handling	NN
cord-017527-ylng1us2	71	12	of	of	IN
cord-017527-ylng1us2	71	13	cell	cell	NN
cord-017527-ylng1us2	71	14	cultures	culture	NNS
cord-017527-ylng1us2	71	15	and/or	and/or	CC
cord-017527-ylng1us2	71	16	containing	contain	VBG
cord-017527-ylng1us2	71	17	virus	virus	NN
cord-017527-ylng1us2	71	18	suspension	suspension	NN
cord-017527-ylng1us2	71	19	have	have	VBP
cord-017527-ylng1us2	71	20	been	be	VBN
cord-017527-ylng1us2	71	21	reported	report	VBN
cord-017527-ylng1us2	71	22	.	.	.
cord-017527-ylng1us2	72	1	Among	among	IN
cord-017527-ylng1us2	72	2	them	-PRON-	PRP
cord-017527-ylng1us2	72	3	are	be	VBP
cord-017527-ylng1us2	72	4	the	the	DT
cord-017527-ylng1us2	72	5	reported	report	VBN
cord-017527-ylng1us2	72	6	laboratory	laboratory	NN
cord-017527-ylng1us2	72	7	worker	worker	NN
cord-017527-ylng1us2	72	8	's	's	POS
cord-017527-ylng1us2	72	9	exposure	exposure	NN
cord-017527-ylng1us2	72	10	to	to	IN
cord-017527-ylng1us2	72	11	(	(	-LRB-
cord-017527-ylng1us2	72	12	recombinant	recombinant	JJ
cord-017527-ylng1us2	72	13	)	)	-RRB-
cord-017527-ylng1us2	72	14	vaccinia	vaccinia	NN
cord-017527-ylng1us2	72	15	viruses	virus	NNS
cord-017527-ylng1us2	72	16	amplified	amplify	VBN
cord-017527-ylng1us2	72	17	in	in	IN
cord-017527-ylng1us2	72	18	cell	cell	NN
cord-017527-ylng1us2	72	19	culture	culture	NN
cord-017527-ylng1us2	72	20	resulting	result	VBG
cord-017527-ylng1us2	72	21	into	into	IN
cord-017527-ylng1us2	72	22	infections	infection	NNS
cord-017527-ylng1us2	72	23	Openshaw	Openshaw	NNP
cord-017527-ylng1us2	72	24	et	et	NNP
cord-017527-ylng1us2	72	25	al	al	NNP
cord-017527-ylng1us2	72	26	.	.	.
cord-017527-ylng1us2	72	27	1991	1991	CD
cord-017527-ylng1us2	72	28	;	;	:
cord-017527-ylng1us2	73	1	Mempel	Mempel	NNP
cord-017527-ylng1us2	73	2	et	et	NNP
cord-017527-ylng1us2	73	3	al	al	NNP
cord-017527-ylng1us2	73	4	.	.	.
cord-017527-ylng1us2	74	1	2003	2003	CD
cord-017527-ylng1us2	74	2	;	;	:
cord-017527-ylng1us2	74	3	Moussatché	Moussatché	NNP
cord-017527-ylng1us2	74	4	et	et	NNP
cord-017527-ylng1us2	74	5	al	al	NNP
cord-017527-ylng1us2	74	6	.	.	.
cord-017527-ylng1us2	75	1	2003	2003	CD
cord-017527-ylng1us2	75	2	;	;	:
cord-017527-ylng1us2	75	3	Wlodaver	Wlodaver	NNP
cord-017527-ylng1us2	75	4	et	et	NNP
cord-017527-ylng1us2	75	5	al	al	NNP
cord-017527-ylng1us2	75	6	.	.	.
cord-017527-ylng1us2	76	1	2004	2004	CD
cord-017527-ylng1us2	76	2	;	;	:
cord-017527-ylng1us2	76	3	Lewis	Lewis	NNP
cord-017527-ylng1us2	76	4	et	et	NNP
cord-017527-ylng1us2	76	5	al	al	NNP
cord-017527-ylng1us2	76	6	.	.	.
cord-017527-ylng1us2	77	1	2006	2006	CD
cord-017527-ylng1us2	77	2	;	;	:
cord-017527-ylng1us2	77	3	Centers	Centers	NNPS
cord-017527-ylng1us2	77	4	for	for	IN
cord-017527-ylng1us2	77	5	Disease	Disease	NNP
cord-017527-ylng1us2	77	6	Control	Control	NNP
cord-017527-ylng1us2	77	7	and	and	CC
cord-017527-ylng1us2	77	8	Prevention	Prevention	NNP
cord-017527-ylng1us2	77	9	2009b	2009b	CD
cord-017527-ylng1us2	77	10	)	)	-RRB-
cord-017527-ylng1us2	77	11	.	.	.
cord-017527-ylng1us2	78	1	Recommendations	recommendation	NNS
cord-017527-ylng1us2	78	2	to	to	TO
cord-017527-ylng1us2	78	3	work	work	VB
cord-017527-ylng1us2	78	4	safely	safely	RB
cord-017527-ylng1us2	78	5	with	with	IN
cord-017527-ylng1us2	78	6	vaccinia	vaccinia	NN
cord-017527-ylng1us2	78	7	virus	virus	NN
cord-017527-ylng1us2	78	8	have	have	VBP
cord-017527-ylng1us2	78	9	been	be	VBN
cord-017527-ylng1us2	78	10	reviewed	review	VBN
cord-017527-ylng1us2	78	11	recently	recently	RB
cord-017527-ylng1us2	78	12	together	together	RB
cord-017527-ylng1us2	78	13	with	with	IN
cord-017527-ylng1us2	78	14	an	an	DT
cord-017527-ylng1us2	78	15	overview	overview	NN
cord-017527-ylng1us2	78	16	on	on	IN
cord-017527-ylng1us2	78	17	the	the	DT
cord-017527-ylng1us2	78	18	reported	report	VBN
cord-017527-ylng1us2	78	19	cases	case	NNS
cord-017527-ylng1us2	78	20	of	of	IN
cord-017527-ylng1us2	78	21	LAIs	lai	NNS
cord-017527-ylng1us2	78	22	involving	involve	VBG
cord-017527-ylng1us2	78	23	this	this	DT
cord-017527-ylng1us2	78	24	virus	virus	NN
cord-017527-ylng1us2	78	25	(	(	-LRB-
cord-017527-ylng1us2	78	26	Isaacs	Isaacs	NNP
cord-017527-ylng1us2	78	27	2012	2012	CD
cord-017527-ylng1us2	78	28	)	)	-RRB-
cord-017527-ylng1us2	78	29	.	.	.
cord-017527-ylng1us2	79	1	The	the	DT
cord-017527-ylng1us2	79	2	risk	risk	NN
cord-017527-ylng1us2	79	3	assessment	assessment	NN
cord-017527-ylng1us2	79	4	of	of	IN
cord-017527-ylng1us2	79	5	cell	cell	NN
cord-017527-ylng1us2	79	6	cultures	culture	NNS
cord-017527-ylng1us2	79	7	that	that	WDT
cord-017527-ylng1us2	79	8	are	be	VBP
cord-017527-ylng1us2	79	9	genetically	genetically	RB
cord-017527-ylng1us2	79	10	modified	modify	VBN
cord-017527-ylng1us2	79	11	basically	basically	RB
cord-017527-ylng1us2	79	12	follows	follow	VBZ
cord-017527-ylng1us2	79	13	a	a	DT
cord-017527-ylng1us2	79	14	comparative	comparative	JJ
cord-017527-ylng1us2	79	15	approach	approach	NN
cord-017527-ylng1us2	79	16	:	:	:
cord-017527-ylng1us2	79	17	the	the	DT
cord-017527-ylng1us2	79	18	characteristics	characteristic	NNS
cord-017527-ylng1us2	79	19	of	of	IN
cord-017527-ylng1us2	79	20	the	the	DT
cord-017527-ylng1us2	79	21	GMO	GMO	NNP
cord-017527-ylng1us2	79	22	are	be	VBP
cord-017527-ylng1us2	79	23	compared	compare	VBN
cord-017527-ylng1us2	79	24	to	to	IN
cord-017527-ylng1us2	79	25	those	those	DT
cord-017527-ylng1us2	79	26	of	of	IN
cord-017527-ylng1us2	79	27	the	the	DT
cord-017527-ylng1us2	79	28	non	non	JJ
cord-017527-ylng1us2	79	29	-	-	JJ
cord-017527-ylng1us2	79	30	modified	modified	JJ
cord-017527-ylng1us2	79	31	(	(	-LRB-
cord-017527-ylng1us2	79	32	wild	wild	JJ
cord-017527-ylng1us2	79	33	-	-	HYPH
cord-017527-ylng1us2	79	34	type	type	NN
cord-017527-ylng1us2	79	35	)	)	-RRB-
cord-017527-ylng1us2	79	36	organism	organism	NN
cord-017527-ylng1us2	79	37	from	from	IN
cord-017527-ylng1us2	79	38	which	which	WDT
cord-017527-ylng1us2	79	39	it	-PRON-	PRP
cord-017527-ylng1us2	79	40	is	be	VBZ
cord-017527-ylng1us2	79	41	derived	derive	VBN
cord-017527-ylng1us2	79	42	under	under	IN
cord-017527-ylng1us2	79	43	corresponding	corresponding	JJ
cord-017527-ylng1us2	79	44	situations	situation	NNS
cord-017527-ylng1us2	79	45	of	of	IN
cord-017527-ylng1us2	79	46	use	use	NN
cord-017527-ylng1us2	79	47	.	.	.
cord-017527-ylng1us2	80	1	The	the	DT
cord-017527-ylng1us2	80	2	distinctive	distinctive	JJ
cord-017527-ylng1us2	80	3	feature	feature	NN
cord-017527-ylng1us2	80	4	of	of	IN
cord-017527-ylng1us2	80	5	the	the	DT
cord-017527-ylng1us2	80	6	risk	risk	NN
cord-017527-ylng1us2	80	7	assessment	assessment	NN
cord-017527-ylng1us2	80	8	of	of	IN
cord-017527-ylng1us2	80	9	genetically	genetically	RB
cord-017527-ylng1us2	80	10	modified	modify	VBN
cord-017527-ylng1us2	80	11	cell	cell	NN
cord-017527-ylng1us2	80	12	cultures	culture	NNS
cord-017527-ylng1us2	80	13	which	which	WDT
cord-017527-ylng1us2	80	14	consists	consist	VBZ
cord-017527-ylng1us2	80	15	of	of	IN
cord-017527-ylng1us2	80	16	the	the	DT
cord-017527-ylng1us2	80	17	evaluation	evaluation	NN
cord-017527-ylng1us2	80	18	of	of	IN
cord-017527-ylng1us2	80	19	the	the	DT
cord-017527-ylng1us2	80	20	recipient	recipient	NN
cord-017527-ylng1us2	80	21	cell	cell	NN
cord-017527-ylng1us2	80	22	,	,	,
cord-017527-ylng1us2	80	23	the	the	DT
cord-017527-ylng1us2	80	24	vector	vector	NN
cord-017527-ylng1us2	80	25	,	,	,
cord-017527-ylng1us2	80	26	the	the	DT
cord-017527-ylng1us2	80	27	donor	donor	NN
cord-017527-ylng1us2	80	28	organisms	organism	NNS
cord-017527-ylng1us2	80	29	and	and	CC
cord-017527-ylng1us2	80	30	the	the	DT
cord-017527-ylng1us2	80	31	inserted	insert	VBN
cord-017527-ylng1us2	80	32	genetic	genetic	JJ
cord-017527-ylng1us2	80	33	material	material	NN
cord-017527-ylng1us2	80	34	(	(	-LRB-
cord-017527-ylng1us2	80	35	insert	insert	NN
cord-017527-ylng1us2	80	36	)	)	-RRB-
cord-017527-ylng1us2	80	37	is	be	VBZ
cord-017527-ylng1us2	80	38	developed	develop	VBN
cord-017527-ylng1us2	80	39	in	in	IN
cord-017527-ylng1us2	80	40	Sect	Sect	NNP
cord-017527-ylng1us2	80	41	.	.	.
cord-017527-ylng1us2	81	1	22.2.5	22.2.5	CD
cord-017527-ylng1us2	81	2	.	.	.
cord-017527-ylng1us2	82	1	Good	good	JJ
cord-017527-ylng1us2	82	2	knowledge	knowledge	NN
cord-017527-ylng1us2	82	3	and	and	CC
cord-017527-ylng1us2	82	4	characterisation	characterisation	NN
cord-017527-ylng1us2	82	5	of	of	IN
cord-017527-ylng1us2	82	6	the	the	DT
cord-017527-ylng1us2	82	7	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	82	8	properties	property	NNS
cord-017527-ylng1us2	82	9	of	of	IN
cord-017527-ylng1us2	82	10	cells	cell	NNS
cord-017527-ylng1us2	82	11	are	be	VBP
cord-017527-ylng1us2	82	12	key	key	JJ
cord-017527-ylng1us2	82	13	to	to	IN
cord-017527-ylng1us2	82	14	successful	successful	JJ
cord-017527-ylng1us2	82	15	and	and	CC
cord-017527-ylng1us2	82	16	safe	safe	JJ
cord-017527-ylng1us2	82	17	cell	cell	NN
cord-017527-ylng1us2	82	18	culturing	culturing	NN
cord-017527-ylng1us2	82	19	.	.	.
cord-017527-ylng1us2	83	1	With	with	IN
cord-017527-ylng1us2	83	2	respect	respect	NN
cord-017527-ylng1us2	83	3	to	to	IN
cord-017527-ylng1us2	83	4	the	the	DT
cord-017527-ylng1us2	83	5	biological	biological	JJ
cord-017527-ylng1us2	83	6	risks	risk	NNS
cord-017527-ylng1us2	83	7	and	and	CC
cord-017527-ylng1us2	83	8	the	the	DT
cord-017527-ylng1us2	83	9	risk	risk	NN
cord-017527-ylng1us2	83	10	assessment	assessment	NN
cord-017527-ylng1us2	83	11	associated	associate	VBN
cord-017527-ylng1us2	83	12	with	with	IN
cord-017527-ylng1us2	83	13	the	the	DT
cord-017527-ylng1us2	83	14	manipulation	manipulation	NN
cord-017527-ylng1us2	83	15	of	of	IN
cord-017527-ylng1us2	83	16	animal	animal	NN
cord-017527-ylng1us2	83	17	cell	cell	NN
cord-017527-ylng1us2	83	18	cultures	culture	NNS
cord-017527-ylng1us2	83	19	,	,	,
cord-017527-ylng1us2	83	20	three	three	CD
cord-017527-ylng1us2	83	21	properties	property	NNS
cord-017527-ylng1us2	83	22	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	83	23	to	to	IN
cord-017527-ylng1us2	83	24	cell	cell	NN
cord-017527-ylng1us2	83	25	cultures	culture	NNS
cord-017527-ylng1us2	83	26	should	should	MD
cord-017527-ylng1us2	83	27	be	be	VB
cord-017527-ylng1us2	83	28	considered	consider	VBN
cord-017527-ylng1us2	83	29	:	:	:
cord-017527-ylng1us2	83	30	the	the	DT
cord-017527-ylng1us2	83	31	species	specie	NNS
cord-017527-ylng1us2	83	32	of	of	IN
cord-017527-ylng1us2	83	33	origin	origin	NN
cord-017527-ylng1us2	83	34	,	,	,
cord-017527-ylng1us2	83	35	the	the	DT
cord-017527-ylng1us2	83	36	cell	cell	NN
cord-017527-ylng1us2	83	37	type	type	NN
cord-017527-ylng1us2	83	38	or	or	CC
cord-017527-ylng1us2	83	39	type	type	NN
cord-017527-ylng1us2	83	40	of	of	IN
cord-017527-ylng1us2	83	41	tissue	tissue	NN
cord-017527-ylng1us2	83	42	,	,	,
cord-017527-ylng1us2	83	43	organ	organ	NN
cord-017527-ylng1us2	83	44	from	from	IN
cord-017527-ylng1us2	83	45	which	which	WDT
cord-017527-ylng1us2	83	46	the	the	DT
cord-017527-ylng1us2	83	47	cell	cell	NN
cord-017527-ylng1us2	83	48	line	line	NN
cord-017527-ylng1us2	83	49	is	be	VBZ
cord-017527-ylng1us2	83	50	derived	derive	VBN
cord-017527-ylng1us2	83	51	and	and	CC
cord-017527-ylng1us2	83	52	the	the	DT
cord-017527-ylng1us2	83	53	status	status	NN
cord-017527-ylng1us2	83	54	of	of	IN
cord-017527-ylng1us2	83	55	the	the	DT
cord-017527-ylng1us2	83	56	culture	culture	NN
cord-017527-ylng1us2	83	57	(	(	-LRB-
cord-017527-ylng1us2	83	58	Fig	Fig	NNP
cord-017527-ylng1us2	83	59	.	.	.
cord-017527-ylng1us2	83	60	22	22	CD
cord-017527-ylng1us2	83	61	.2	.2	CD
cord-017527-ylng1us2	83	62	)	)	-RRB-
cord-017527-ylng1us2	83	63	.	.	.
cord-017527-ylng1us2	84	1	With	with	IN
cord-017527-ylng1us2	84	2	respect	respect	NN
cord-017527-ylng1us2	84	3	to	to	IN
cord-017527-ylng1us2	84	4	the	the	DT
cord-017527-ylng1us2	84	5	species	specie	NNS
cord-017527-ylng1us2	84	6	of	of	IN
cord-017527-ylng1us2	84	7	origin	origin	NN
cord-017527-ylng1us2	84	8	and	and	CC
cord-017527-ylng1us2	84	9	based	base	VBN
cord-017527-ylng1us2	84	10	on	on	IN
cord-017527-ylng1us2	84	11	the	the	DT
cord-017527-ylng1us2	84	12	fact	fact	NN
cord-017527-ylng1us2	84	13	that	that	IN
cord-017527-ylng1us2	84	14	pathogens	pathogen	NNS
cord-017527-ylng1us2	84	15	usually	usually	RB
cord-017527-ylng1us2	84	16	have	have	VBP
cord-017527-ylng1us2	84	17	specific	specific	JJ
cord-017527-ylng1us2	84	18	species	species	NN
cord-017527-ylng1us2	84	19	barriers	barrier	NNS
cord-017527-ylng1us2	84	20	,	,	,
cord-017527-ylng1us2	84	21	it	-PRON-	PRP
cord-017527-ylng1us2	84	22	is	be	VBZ
cord-017527-ylng1us2	84	23	considered	consider	VBN
cord-017527-ylng1us2	84	24	that	that	IN
cord-017527-ylng1us2	84	25	the	the	DT
cord-017527-ylng1us2	84	26	closer	close	JJR
cord-017527-ylng1us2	84	27	the	the	DT
cord-017527-ylng1us2	84	28	genetic	genetic	JJ
cord-017527-ylng1us2	84	29	relationship	relationship	NN
cord-017527-ylng1us2	84	30	of	of	IN
cord-017527-ylng1us2	84	31	the	the	DT
cord-017527-ylng1us2	84	32	cell	cell	NN
cord-017527-ylng1us2	84	33	culture	culture	NN
cord-017527-ylng1us2	84	34	is	be	VBZ
cord-017527-ylng1us2	84	35	to	to	IN
cord-017527-ylng1us2	84	36	humans	human	NNS
cord-017527-ylng1us2	84	37	,	,	,
cord-017527-ylng1us2	84	38	the	the	DT
cord-017527-ylng1us2	84	39	higher	high	JJR
cord-017527-ylng1us2	84	40	the	the	DT
cord-017527-ylng1us2	84	41	risk	risk	NN
cord-017527-ylng1us2	84	42	is	be	VBZ
cord-017527-ylng1us2	84	43	to	to	IN
cord-017527-ylng1us2	84	44	humans	human	NNS
cord-017527-ylng1us2	84	45	.	.	.
cord-017527-ylng1us2	85	1	The	the	DT
cord-017527-ylng1us2	85	2	incidence	incidence	NN
cord-017527-ylng1us2	85	3	to	to	TO
cord-017527-ylng1us2	85	4	harbour	harbour	VB
cord-017527-ylng1us2	85	5	organisms	organism	NNS
cord-017527-ylng1us2	85	6	that	that	WDT
cord-017527-ylng1us2	85	7	could	could	MD
cord-017527-ylng1us2	85	8	cause	cause	VB
cord-017527-ylng1us2	85	9	harm	harm	NN
cord-017527-ylng1us2	85	10	to	to	IN
cord-017527-ylng1us2	85	11	human	human	JJ
cord-017527-ylng1us2	85	12	health	health	NN
cord-017527-ylng1us2	85	13	is	be	VBZ
cord-017527-ylng1us2	85	14	therefore	therefore	RB
cord-017527-ylng1us2	85	15	considered	consider	VBN
cord-017527-ylng1us2	85	16	higher	high	JJR
cord-017527-ylng1us2	85	17	in	in	IN
cord-017527-ylng1us2	85	18	human	human	JJ
cord-017527-ylng1us2	85	19	or	or	CC
cord-017527-ylng1us2	85	20	primate	primate	JJ
cord-017527-ylng1us2	85	21	cells	cell	NNS
cord-017527-ylng1us2	85	22	compared	compare	VBN
cord-017527-ylng1us2	85	23	to	to	IN
cord-017527-ylng1us2	85	24	cells	cell	NNS
cord-017527-ylng1us2	85	25	of	of	IN
cord-017527-ylng1us2	85	26	non	non	JJ
cord-017527-ylng1us2	85	27	-	-	JJ
cord-017527-ylng1us2	85	28	human	human	JJ
cord-017527-ylng1us2	85	29	origin	origin	NN
cord-017527-ylng1us2	85	30	(	(	-LRB-
cord-017527-ylng1us2	85	31	Brown	Brown	NNP
cord-017527-ylng1us2	85	32	1997	1997	CD
cord-017527-ylng1us2	85	33	)	)	-RRB-
cord-017527-ylng1us2	85	34	.	.	.
cord-017527-ylng1us2	86	1	Accordingly	accordingly	RB
cord-017527-ylng1us2	86	2	,	,	,
cord-017527-ylng1us2	86	3	mammalian	mammalian	JJ
cord-017527-ylng1us2	86	4	cells	cell	NNS
cord-017527-ylng1us2	86	5	other	other	JJ
cord-017527-ylng1us2	86	6	than	than	IN
cord-017527-ylng1us2	86	7	human	human	JJ
cord-017527-ylng1us2	86	8	or	or	CC
cord-017527-ylng1us2	86	9	primate	primate	JJ
cord-017527-ylng1us2	86	10	cells	cell	NNS
cord-017527-ylng1us2	86	11	are	be	VBP
cord-017527-ylng1us2	86	12	considered	consider	VBN
cord-017527-ylng1us2	86	13	to	to	TO
cord-017527-ylng1us2	86	14	represent	represent	VB
cord-017527-ylng1us2	86	15	less	less	JJR
cord-017527-ylng1us2	86	16	risk	risk	NN
cord-017527-ylng1us2	86	17	,	,	,
cord-017527-ylng1us2	86	18	followed	follow	VBN
cord-017527-ylng1us2	86	19	by	by	IN
cord-017527-ylng1us2	86	20	avian	avian	JJ
cord-017527-ylng1us2	86	21	and	and	CC
cord-017527-ylng1us2	86	22	invertebrate	invertebrate	JJ
cord-017527-ylng1us2	86	23	cells	cell	NNS
cord-017527-ylng1us2	86	24	.	.	.
cord-017527-ylng1us2	87	1	However	however	RB
cord-017527-ylng1us2	87	2	,	,	,
cord-017527-ylng1us2	87	3	it	-PRON-	PRP
cord-017527-ylng1us2	87	4	should	should	MD
cord-017527-ylng1us2	87	5	be	be	VB
cord-017527-ylng1us2	87	6	kept	keep	VBN
cord-017527-ylng1us2	87	7	in	in	IN
cord-017527-ylng1us2	87	8	mind	mind	NN
cord-017527-ylng1us2	87	9	that	that	IN
cord-017527-ylng1us2	87	10	some	some	DT
cord-017527-ylng1us2	87	11	infectious	infectious	JJ
cord-017527-ylng1us2	87	12	agents	agent	NNS
cord-017527-ylng1us2	87	13	are	be	VBP
cord-017527-ylng1us2	87	14	able	able	JJ
cord-017527-ylng1us2	87	15	to	to	TO
cord-017527-ylng1us2	87	16	cross	cross	VB
cord-017527-ylng1us2	87	17	the	the	DT
cord-017527-ylng1us2	87	18	species	specie	NNS
cord-017527-ylng1us2	87	19	barrier	barrier	NN
cord-017527-ylng1us2	87	20	and	and	CC
cord-017527-ylng1us2	87	21	to	to	TO
cord-017527-ylng1us2	87	22	persist	persist	VB
cord-017527-ylng1us2	87	23	in	in	IN
cord-017527-ylng1us2	87	24	new	new	JJ
cord-017527-ylng1us2	87	25	host	host	NN
cord-017527-ylng1us2	87	26	species	specie	NNS
cord-017527-ylng1us2	87	27	,	,	,
cord-017527-ylng1us2	87	28	leading	lead	VBG
cord-017527-ylng1us2	87	29	to	to	IN
cord-017527-ylng1us2	87	30	zoonotic	zoonotic	JJ
cord-017527-ylng1us2	87	31	diseases	disease	NNS
cord-017527-ylng1us2	87	32	.	.	.
cord-017527-ylng1us2	88	1	It	-PRON-	PRP
cord-017527-ylng1us2	88	2	is	be	VBZ
cord-017527-ylng1us2	88	3	acknowledged	acknowledge	VBN
cord-017527-ylng1us2	88	4	since	since	IN
cord-017527-ylng1us2	88	5	many	many	JJ
cord-017527-ylng1us2	88	6	years	year	NNS
cord-017527-ylng1us2	88	7	that	that	IN
cord-017527-ylng1us2	88	8	more	more	RBR
cord-017527-ylng1us2	88	9	or	or	CC
cord-017527-ylng1us2	88	10	less	less	RBR
cord-017527-ylng1us2	88	11	70	70	CD
cord-017527-ylng1us2	88	12	%	%	NN
cord-017527-ylng1us2	88	13	of	of	IN
cord-017527-ylng1us2	88	14	the	the	DT
cord-017527-ylng1us2	88	15	emerging	emerge	VBG
cord-017527-ylng1us2	88	16	infectious	infectious	JJ
cord-017527-ylng1us2	88	17	diseases	disease	NNS
cord-017527-ylng1us2	88	18	are	be	VBP
cord-017527-ylng1us2	88	19	zoonotic	zoonotic	JJ
cord-017527-ylng1us2	89	1	(	(	-LRB-
cord-017527-ylng1us2	89	2	Chomel	Chomel	NNP
cord-017527-ylng1us2	89	3	et	et	FW
cord-017527-ylng1us2	89	4	al	al	NNP
cord-017527-ylng1us2	89	5	.	.	NNP
cord-017527-ylng1us2	89	6	2007	2007	CD
cord-017527-ylng1us2	89	7	)	)	-RRB-
cord-017527-ylng1us2	89	8	.	.	.
cord-017527-ylng1us2	90	1	Well	well	UH
cord-017527-ylng1us2	90	2	documented	document	VBN
cord-017527-ylng1us2	90	3	cases	case	NNS
cord-017527-ylng1us2	90	4	of	of	IN
cord-017527-ylng1us2	90	5	viruses	virus	NNS
cord-017527-ylng1us2	90	6	that	that	WDT
cord-017527-ylng1us2	90	7	have	have	VBP
cord-017527-ylng1us2	90	8	crossed	cross	VBN
cord-017527-ylng1us2	90	9	the	the	DT
cord-017527-ylng1us2	90	10	species	specie	NNS
cord-017527-ylng1us2	90	11	barrier	barrier	NN
cord-017527-ylng1us2	90	12	from	from	IN
cord-017527-ylng1us2	90	13	animal	animal	NN
cord-017527-ylng1us2	90	14	reservoirs	reservoir	NNS
cord-017527-ylng1us2	90	15	to	to	IN
cord-017527-ylng1us2	90	16	humans	human	NNS
cord-017527-ylng1us2	90	17	include	include	VBP
cord-017527-ylng1us2	90	18	hantavirus	hantavirus	NN
cord-017527-ylng1us2	90	19	(	(	-LRB-
cord-017527-ylng1us2	90	20	murine	murine	JJ
cord-017527-ylng1us2	90	21	reservoir	reservoir	NN
cord-017527-ylng1us2	90	22	)	)	-RRB-
cord-017527-ylng1us2	90	23	,	,	,
cord-017527-ylng1us2	90	24	haemorrhagic	haemorrhagic	JJ
cord-017527-ylng1us2	90	25	fever	fever	NN
cord-017527-ylng1us2	90	26	viruses	virus	NNS
cord-017527-ylng1us2	90	27	(	(	-LRB-
cord-017527-ylng1us2	90	28	Ebola	Ebola	NNP
cord-017527-ylng1us2	90	29	,	,	,
cord-017527-ylng1us2	90	30	Marburg	Marburg	NNP
cord-017527-ylng1us2	90	31	)	)	-RRB-
cord-017527-ylng1us2	90	32	(	(	-LRB-
cord-017527-ylng1us2	90	33	Peters	Peters	NNP
cord-017527-ylng1us2	90	34	et	et	NNP
cord-017527-ylng1us2	90	35	al	al	NNP
cord-017527-ylng1us2	90	36	.	.	NNP
cord-017527-ylng1us2	90	37	1992	1992	CD
cord-017527-ylng1us2	90	38	)	)	-RRB-
cord-017527-ylng1us2	90	39	,	,	,
cord-017527-ylng1us2	90	40	avian	avian	JJ
cord-017527-ylng1us2	90	41	Influenza	Influenza	NNP
cord-017527-ylng1us2	90	42	virus	virus	NN
cord-017527-ylng1us2	90	43	(	(	-LRB-
cord-017527-ylng1us2	90	44	Reperant	Reperant	NNP
cord-017527-ylng1us2	90	45	et	et	NNP
cord-017527-ylng1us2	90	46	al	al	NNP
cord-017527-ylng1us2	90	47	.	.	.
cord-017527-ylng1us2	90	48	2012	2012	CD
cord-017527-ylng1us2	90	49	)	)	-RRB-
cord-017527-ylng1us2	90	50	and	and	CC
cord-017527-ylng1us2	90	51	Severe	severe	JJ
cord-017527-ylng1us2	90	52	acute	acute	JJ
cord-017527-ylng1us2	90	53	respiratory	respiratory	JJ
cord-017527-ylng1us2	90	54	syndrome	syndrome	NN
cord-017527-ylng1us2	90	55	(	(	-LRB-
cord-017527-ylng1us2	90	56	SARS	SARS	NNP
cord-017527-ylng1us2	90	57	)	)	-RRB-
cord-017527-ylng1us2	90	58	associated	associate	VBD
cord-017527-ylng1us2	90	59	coronavirus	coronavirus	NN
cord-017527-ylng1us2	90	60	(	(	-LRB-
cord-017527-ylng1us2	90	61	Ksiazek	Ksiazek	NNP
cord-017527-ylng1us2	90	62	et	et	NNP
cord-017527-ylng1us2	90	63	al	al	NNP
cord-017527-ylng1us2	90	64	.	.	NNP
cord-017527-ylng1us2	90	65	2003	2003	CD
cord-017527-ylng1us2	90	66	;	;	:
cord-017527-ylng1us2	90	67	Herman	Herman	NNP
cord-017527-ylng1us2	90	68	et	et	NNP
cord-017527-ylng1us2	90	69	al	al	NNP
cord-017527-ylng1us2	90	70	.	.	.
cord-017527-ylng1us2	90	71	2004	2004	CD
cord-017527-ylng1us2	90	72	)	)	-RRB-
cord-017527-ylng1us2	90	73	.	.	.
cord-017527-ylng1us2	91	1	These	these	DT
cord-017527-ylng1us2	91	2	examples	example	NNS
cord-017527-ylng1us2	91	3	show	show	VBP
cord-017527-ylng1us2	91	4	that	that	IN
cord-017527-ylng1us2	91	5	incidences	incidence	NNS
cord-017527-ylng1us2	91	6	of	of	IN
cord-017527-ylng1us2	91	7	cross	cross	JJ
cord-017527-ylng1us2	91	8	-	-	JJ
cord-017527-ylng1us2	91	9	species	species	JJ
cord-017527-ylng1us2	91	10	transfer	transfer	NN
cord-017527-ylng1us2	91	11	can	can	MD
cord-017527-ylng1us2	91	12	occur	occur	VB
cord-017527-ylng1us2	91	13	and	and	CC
cord-017527-ylng1us2	91	14	that	that	IN
cord-017527-ylng1us2	91	15	occupational	occupational	JJ
cord-017527-ylng1us2	91	16	risks	risk	NNS
cord-017527-ylng1us2	91	17	related	relate	VBN
cord-017527-ylng1us2	91	18	to	to	IN
cord-017527-ylng1us2	91	19	exposure	exposure	NN
cord-017527-ylng1us2	91	20	to	to	IN
cord-017527-ylng1us2	91	21	infected	infected	JJ
cord-017527-ylng1us2	91	22	animal	animal	NN
cord-017527-ylng1us2	91	23	tissues	tissue	NNS
cord-017527-ylng1us2	91	24	or	or	CC
cord-017527-ylng1us2	91	25	cell	cell	NN
cord-017527-ylng1us2	91	26	cultures	culture	NNS
cord-017527-ylng1us2	91	27	should	should	MD
cord-017527-ylng1us2	91	28	not	not	RB
cord-017527-ylng1us2	91	29	be	be	VB
cord-017527-ylng1us2	91	30	underestimated	underestimate	VBN
cord-017527-ylng1us2	91	31	(	(	-LRB-
cord-017527-ylng1us2	91	32	Mahy	Mahy	NNP
cord-017527-ylng1us2	91	33	and	and	CC
cord-017527-ylng1us2	91	34	Brown	Brown	NNP
cord-017527-ylng1us2	91	35	2000	2000	CD
cord-017527-ylng1us2	91	36	;	;	:
cord-017527-ylng1us2	92	1	Louz	Louz	NNP
cord-017527-ylng1us2	92	2	et	et	FW
cord-017527-ylng1us2	92	3	al	al	NNP
cord-017527-ylng1us2	92	4	.	.	NNP
cord-017527-ylng1us2	92	5	2005	2005	CD
cord-017527-ylng1us2	92	6	)	)	-RRB-
cord-017527-ylng1us2	92	7	.	.	.
cord-017527-ylng1us2	93	1	Cells	cell	NNS
cord-017527-ylng1us2	93	2	may	may	MD
cord-017527-ylng1us2	93	3	dramatically	dramatically	RB
cord-017527-ylng1us2	93	4	differ	differ	VB
cord-017527-ylng1us2	93	5	in	in	IN
cord-017527-ylng1us2	93	6	their	-PRON-	PRP$
cord-017527-ylng1us2	93	7	in	in	IN
cord-017527-ylng1us2	93	8	vivo	vivo	NN
cord-017527-ylng1us2	93	9	half	half	JJ
cord-017527-ylng1us2	93	10	-	-	HYPH
cord-017527-ylng1us2	93	11	life	life	NN
cord-017527-ylng1us2	93	12	depending	depend	VBG
cord-017527-ylng1us2	93	13	on	on	IN
cord-017527-ylng1us2	93	14	the	the	DT
cord-017527-ylng1us2	93	15	cell	cell	NN
cord-017527-ylng1us2	93	16	type	type	NN
cord-017527-ylng1us2	93	17	or	or	CC
cord-017527-ylng1us2	93	18	type	type	NN
cord-017527-ylng1us2	93	19	of	of	IN
cord-017527-ylng1us2	93	20	tissue	tissue	NN
cord-017527-ylng1us2	93	21	from	from	IN
cord-017527-ylng1us2	93	22	which	which	WDT
cord-017527-ylng1us2	93	23	these	these	DT
cord-017527-ylng1us2	93	24	are	be	VBP
cord-017527-ylng1us2	93	25	derived	derive	VBN
cord-017527-ylng1us2	93	26	.	.	.
cord-017527-ylng1us2	94	1	For	for	IN
cord-017527-ylng1us2	94	2	example	example	NN
cord-017527-ylng1us2	94	3	,	,	,
cord-017527-ylng1us2	94	4	intestinal	intestinal	JJ
cord-017527-ylng1us2	94	5	and	and	CC
cord-017527-ylng1us2	94	6	certain	certain	JJ
cord-017527-ylng1us2	94	7	leukocytes	leukocyte	NNS
cord-017527-ylng1us2	94	8	have	have	VBP
cord-017527-ylng1us2	94	9	a	a	DT
cord-017527-ylng1us2	94	10	half	half	JJ
cord-017527-ylng1us2	94	11	-	-	HYPH
cord-017527-ylng1us2	94	12	life	life	NN
cord-017527-ylng1us2	94	13	of	of	IN
cord-017527-ylng1us2	94	14	a	a	DT
cord-017527-ylng1us2	94	15	few	few	JJ
cord-017527-ylng1us2	94	16	days	day	NNS
cord-017527-ylng1us2	94	17	,	,	,
cord-017527-ylng1us2	94	18	human	human	JJ
cord-017527-ylng1us2	94	19	erythrocytes	erythrocyte	NNS
cord-017527-ylng1us2	94	20	have	have	VBP
cord-017527-ylng1us2	94	21	approximately	approximately	RB
cord-017527-ylng1us2	94	22	a	a	DT
cord-017527-ylng1us2	94	23	55	55	CD
cord-017527-ylng1us2	94	24	-	-	SYM
cord-017527-ylng1us2	94	25	60-day	60-day	CD
cord-017527-ylng1us2	94	26	half	half	JJ
cord-017527-ylng1us2	94	27	-	-	HYPH
cord-017527-ylng1us2	94	28	life	life	NN
cord-017527-ylng1us2	94	29	,	,	,
cord-017527-ylng1us2	94	30	healthy	healthy	JJ
cord-017527-ylng1us2	94	31	liver	liver	NN
cord-017527-ylng1us2	94	32	cells	cell	NNS
cord-017527-ylng1us2	94	33	have	have	VBP
cord-017527-ylng1us2	94	34	a	a	DT
cord-017527-ylng1us2	94	35	life	life	NN
cord-017527-ylng1us2	94	36	span	span	NN
cord-017527-ylng1us2	94	37	of	of	IN
cord-017527-ylng1us2	94	38	several	several	JJ
cord-017527-ylng1us2	94	39	months	month	NNS
cord-017527-ylng1us2	94	40	,	,	,
cord-017527-ylng1us2	94	41	whereas	whereas	RB
cord-017527-ylng1us2	94	42	,	,	,
cord-017527-ylng1us2	94	43	in	in	IN
cord-017527-ylng1us2	94	44	adults	adult	NNS
cord-017527-ylng1us2	94	45	,	,	,
cord-017527-ylng1us2	94	46	there	there	EX
cord-017527-ylng1us2	94	47	is	be	VBZ
cord-017527-ylng1us2	94	48	a	a	DT
cord-017527-ylng1us2	94	49	slow	slow	JJ
cord-017527-ylng1us2	94	50	loss	loss	NN
cord-017527-ylng1us2	94	51	of	of	IN
cord-017527-ylng1us2	94	52	brain	brain	NN
cord-017527-ylng1us2	94	53	cells	cell	NNS
cord-017527-ylng1us2	94	54	with	with	IN
cord-017527-ylng1us2	94	55	little	little	JJ
cord-017527-ylng1us2	94	56	replacement	replacement	NN
cord-017527-ylng1us2	94	57	.	.	.
cord-017527-ylng1us2	95	1	Partly	partly	RB
cord-017527-ylng1us2	95	2	due	due	JJ
cord-017527-ylng1us2	95	3	to	to	IN
cord-017527-ylng1us2	95	4	this	this	DT
cord-017527-ylng1us2	95	5	fact	fact	NN
cord-017527-ylng1us2	95	6	,	,	,
cord-017527-ylng1us2	95	7	some	some	DT
cord-017527-ylng1us2	95	8	cell	cell	NN
cord-017527-ylng1us2	95	9	lines	line	NNS
cord-017527-ylng1us2	95	10	can	can	MD
cord-017527-ylng1us2	95	11	be	be	VB
cord-017527-ylng1us2	95	12	more	more	RBR
cord-017527-ylng1us2	95	13	readily	readily	RB
cord-017527-ylng1us2	95	14	obtained	obtain	VBN
cord-017527-ylng1us2	95	15	than	than	IN
cord-017527-ylng1us2	95	16	others	other	NNS
cord-017527-ylng1us2	95	17	.	.	.
cord-017527-ylng1us2	96	1	The	the	DT
cord-017527-ylng1us2	96	2	establishment	establishment	NN
cord-017527-ylng1us2	96	3	of	of	IN
cord-017527-ylng1us2	96	4	cell	cell	NN
cord-017527-ylng1us2	96	5	lines	line	NNS
cord-017527-ylng1us2	96	6	is	be	VBZ
cord-017527-ylng1us2	96	7	often	often	RB
cord-017527-ylng1us2	96	8	obtained	obtain	VBN
cord-017527-ylng1us2	96	9	by	by	IN
cord-017527-ylng1us2	96	10	a	a	DT
cord-017527-ylng1us2	96	11	series	series	NN
cord-017527-ylng1us2	96	12	of	of	IN
cord-017527-ylng1us2	96	13	(	(	-LRB-
cord-017527-ylng1us2	96	14	generally	generally	RB
cord-017527-ylng1us2	96	15	uncontrolled	uncontrolled	JJ
cord-017527-ylng1us2	96	16	)	)	-RRB-
cord-017527-ylng1us2	96	17	mutations	mutation	NNS
cord-017527-ylng1us2	96	18	that	that	WDT
cord-017527-ylng1us2	96	19	occur	occur	VBP
cord-017527-ylng1us2	96	20	by	by	IN
cord-017527-ylng1us2	96	21	culturing	culture	VBG
cord-017527-ylng1us2	96	22	cells	cell	NNS
cord-017527-ylng1us2	96	23	for	for	IN
cord-017527-ylng1us2	96	24	a	a	DT
cord-017527-ylng1us2	96	25	longer	long	JJR
cord-017527-ylng1us2	96	26	period	period	NN
cord-017527-ylng1us2	96	27	.	.	.
cord-017527-ylng1us2	97	1	It	-PRON-	PRP
cord-017527-ylng1us2	97	2	is	be	VBZ
cord-017527-ylng1us2	97	3	known	know	VBN
cord-017527-ylng1us2	97	4	that	that	IN
cord-017527-ylng1us2	97	5	cells	cell	NNS
cord-017527-ylng1us2	97	6	cultured	cultured	JJ
cord-017527-ylng1us2	97	7	for	for	IN
cord-017527-ylng1us2	97	8	extensive	extensive	JJ
cord-017527-ylng1us2	97	9	periods	period	NNS
cord-017527-ylng1us2	97	10	of	of	IN
cord-017527-ylng1us2	97	11	time	time	NN
cord-017527-ylng1us2	97	12	display	display	NN
cord-017527-ylng1us2	97	13	changing	change	VBG
cord-017527-ylng1us2	97	14	growth	growth	NN
cord-017527-ylng1us2	97	15	properties	property	NNS
cord-017527-ylng1us2	97	16	.	.	.
cord-017527-ylng1us2	98	1	A	a	DT
cord-017527-ylng1us2	98	2	reduction	reduction	NN
cord-017527-ylng1us2	98	3	of	of	IN
cord-017527-ylng1us2	98	4	the	the	DT
cord-017527-ylng1us2	98	5	doubling	double	VBG
cord-017527-ylng1us2	98	6	time	time	NN
cord-017527-ylng1us2	98	7	,	,	,
cord-017527-ylng1us2	98	8	as	as	IN
cord-017527-ylng1us2	98	9	a	a	DT
cord-017527-ylng1us2	98	10	result	result	NN
cord-017527-ylng1us2	98	11	of	of	IN
cord-017527-ylng1us2	98	12	transformation	transformation	NN
cord-017527-ylng1us2	98	13	,	,	,
cord-017527-ylng1us2	98	14	may	may	MD
cord-017527-ylng1us2	98	15	give	give	VB
cord-017527-ylng1us2	98	16	cells	cell	NNS
cord-017527-ylng1us2	98	17	the	the	DT
cord-017527-ylng1us2	98	18	ability	ability	NN
cord-017527-ylng1us2	98	19	to	to	TO
cord-017527-ylng1us2	98	20	overgrow	overgrow	VB
cord-017527-ylng1us2	98	21	the	the	DT
cord-017527-ylng1us2	98	22	rest	rest	NN
cord-017527-ylng1us2	98	23	of	of	IN
cord-017527-ylng1us2	98	24	the	the	DT
cord-017527-ylng1us2	98	25	population	population	NN
cord-017527-ylng1us2	98	26	and	and	CC
cord-017527-ylng1us2	98	27	to	to	TO
cord-017527-ylng1us2	98	28	survive	survive	VB
cord-017527-ylng1us2	98	29	for	for	IN
cord-017527-ylng1us2	98	30	a	a	DT
cord-017527-ylng1us2	98	31	large	large	JJ
cord-017527-ylng1us2	98	32	(	(	-LRB-
cord-017527-ylng1us2	98	33	infinite	infinite	JJ
cord-017527-ylng1us2	98	34	)	)	-RRB-
cord-017527-ylng1us2	98	35	number	number	NN
cord-017527-ylng1us2	98	36	of	of	IN
cord-017527-ylng1us2	98	37	passages	passage	NNS
cord-017527-ylng1us2	98	38	compared	compare	VBN
cord-017527-ylng1us2	98	39	to	to	IN
cord-017527-ylng1us2	98	40	primary	primary	JJ
cord-017527-ylng1us2	98	41	cells	cell	NNS
cord-017527-ylng1us2	98	42	with	with	IN
cord-017527-ylng1us2	98	43	a	a	DT
cord-017527-ylng1us2	98	44	finite	finite	JJ
cord-017527-ylng1us2	98	45	life	life	NN
cord-017527-ylng1us2	98	46	span	span	NN
cord-017527-ylng1us2	98	47	.	.	.
cord-017527-ylng1us2	99	1	Therefore	therefore	RB
cord-017527-ylng1us2	99	2	,	,	,
cord-017527-ylng1us2	99	3	the	the	DT
cord-017527-ylng1us2	99	4	establishment	establishment	NN
cord-017527-ylng1us2	99	5	of	of	IN
cord-017527-ylng1us2	99	6	cell	cell	NN
cord-017527-ylng1us2	99	7	cultures	culture	NNS
cord-017527-ylng1us2	99	8	of	of	IN
cord-017527-ylng1us2	99	9	a	a	DT
cord-017527-ylng1us2	99	10	certain	certain	JJ
cord-017527-ylng1us2	99	11	cell	cell	NN
cord-017527-ylng1us2	99	12	type	type	NN
cord-017527-ylng1us2	99	13	upon	upon	IN
cord-017527-ylng1us2	99	14	extensive	extensive	JJ
cord-017527-ylng1us2	99	15	passage	passage	NN
cord-017527-ylng1us2	99	16	relies	rely	VBZ
cord-017527-ylng1us2	99	17	on	on	IN
cord-017527-ylng1us2	99	18	the	the	DT
cord-017527-ylng1us2	99	19	positive	positive	JJ
cord-017527-ylng1us2	99	20	selection	selection	NN
cord-017527-ylng1us2	99	21	for	for	IN
cord-017527-ylng1us2	99	22	cells	cell	NNS
cord-017527-ylng1us2	99	23	that	that	WDT
cord-017527-ylng1us2	99	24	have	have	VBP
cord-017527-ylng1us2	99	25	a	a	DT
cord-017527-ylng1us2	99	26	growth	growth	NN
cord-017527-ylng1us2	99	27	advantage	advantage	NN
cord-017527-ylng1us2	99	28	.	.	.
cord-017527-ylng1us2	100	1	These	these	DT
cord-017527-ylng1us2	100	2	transformed	transform	VBN
cord-017527-ylng1us2	100	3	cells	cell	NNS
cord-017527-ylng1us2	100	4	can	can	MD
cord-017527-ylng1us2	100	5	have	have	VB
cord-017527-ylng1us2	100	6	an	an	DT
cord-017527-ylng1us2	100	7	increased	increase	VBN
cord-017527-ylng1us2	100	8	tumorigenic	tumorigenic	JJ
cord-017527-ylng1us2	100	9	potential	potential	NN
cord-017527-ylng1us2	100	10	and	and	CC
cord-017527-ylng1us2	100	11	may	may	MD
cord-017527-ylng1us2	100	12	present	present	VB
cord-017527-ylng1us2	100	13	more	more	JJR
cord-017527-ylng1us2	100	14	risks	risk	NNS
cord-017527-ylng1us2	100	15	of	of	IN
cord-017527-ylng1us2	100	16	becoming	become	VBG
cord-017527-ylng1us2	100	17	/	/	SYM
cord-017527-ylng1us2	100	18	being	be	VBG
cord-017527-ylng1us2	100	19	fully	fully	RB
cord-017527-ylng1us2	100	20	neoplastic	neoplastic	JJ
cord-017527-ylng1us2	100	21	upon	upon	IN
cord-017527-ylng1us2	100	22	accidental	accidental	JJ
cord-017527-ylng1us2	101	1	(	(	-LRB-
cord-017527-ylng1us2	101	2	Gugel	Gugel	NNP
cord-017527-ylng1us2	101	3	and	and	CC
cord-017527-ylng1us2	101	4	Sanders	Sanders	NNP
cord-017527-ylng1us2	101	5	1986	1986	CD
cord-017527-ylng1us2	101	6	)	)	-RRB-
cord-017527-ylng1us2	101	7	or	or	CC
cord-017527-ylng1us2	101	8	deliberate	deliberate	JJ
cord-017527-ylng1us2	101	9	introduction	introduction	NN
cord-017527-ylng1us2	101	10	into	into	IN
cord-017527-ylng1us2	101	11	the	the	DT
cord-017527-ylng1us2	101	12	human	human	JJ
cord-017527-ylng1us2	101	13	body	body	NN
cord-017527-ylng1us2	101	14	.	.	.
cord-017527-ylng1us2	102	1	Therefore	therefore	RB
cord-017527-ylng1us2	102	2	,	,	,
cord-017527-ylng1us2	102	3	taking	take	VBG
cord-017527-ylng1us2	102	4	the	the	DT
cord-017527-ylng1us2	102	5	tumorigenic	tumorigenic	JJ
cord-017527-ylng1us2	102	6	potential	potential	NN
cord-017527-ylng1us2	102	7	into	into	IN
cord-017527-ylng1us2	102	8	account	account	NN
cord-017527-ylng1us2	102	9	,	,	,
cord-017527-ylng1us2	102	10	the	the	DT
cord-017527-ylng1us2	102	11	following	follow	VBG
cord-017527-ylng1us2	102	12	cell	cell	NN
cord-017527-ylng1us2	102	13	types	type	NNS
cord-017527-ylng1us2	102	14	may	may	MD
cord-017527-ylng1us2	102	15	be	be	VB
cord-017527-ylng1us2	102	16	ranked	rank	VBN
cord-017527-ylng1us2	102	17	in	in	IN
cord-017527-ylng1us2	102	18	increasing	increase	VBG
cord-017527-ylng1us2	102	19	order	order	NN
cord-017527-ylng1us2	102	20	of	of	IN
cord-017527-ylng1us2	102	21	risk	risk	NN
cord-017527-ylng1us2	102	22	:	:	:
cord-017527-ylng1us2	102	23	epithelial	epithelial	JJ
cord-017527-ylng1us2	102	24	and	and	CC
cord-017527-ylng1us2	102	25	fibroblast	fibroblast	NN
cord-017527-ylng1us2	102	26	cells	cell	NNS
cord-017527-ylng1us2	102	27	,	,	,
cord-017527-ylng1us2	102	28	gut	gut	NN
cord-017527-ylng1us2	102	29	mucosa	mucosa	NN
cord-017527-ylng1us2	102	30	,	,	,
cord-017527-ylng1us2	102	31	endothelium	endothelium	NN
cord-017527-ylng1us2	102	32	,	,	,
cord-017527-ylng1us2	102	33	neural	neural	JJ
cord-017527-ylng1us2	102	34	tissues	tissue	NNS
cord-017527-ylng1us2	102	35	,	,	,
cord-017527-ylng1us2	102	36	haematogenous	haematogenous	JJ
cord-017527-ylng1us2	102	37	(	(	-LRB-
cord-017527-ylng1us2	102	38	e.g.	e.g.	RB
cord-017527-ylng1us2	102	39	blood	blood	NN
cord-017527-ylng1us2	102	40	,	,	,
cord-017527-ylng1us2	102	41	lymphoid	lymphoid	NN
cord-017527-ylng1us2	102	42	)	)	-RRB-
cord-017527-ylng1us2	102	43	cells	cell	NNS
cord-017527-ylng1us2	102	44	and	and	CC
cord-017527-ylng1us2	102	45	tissue	tissue	NN
cord-017527-ylng1us2	102	46	.	.	.
cord-017527-ylng1us2	103	1	A	a	DT
cord-017527-ylng1us2	103	2	third	third	JJ
cord-017527-ylng1us2	103	3	inherent	inherent	JJ
cord-017527-ylng1us2	103	4	property	property	NN
cord-017527-ylng1us2	103	5	to	to	TO
cord-017527-ylng1us2	103	6	consider	consider	VB
cord-017527-ylng1us2	103	7	is	be	VBZ
cord-017527-ylng1us2	103	8	the	the	DT
cord-017527-ylng1us2	103	9	status	status	NN
cord-017527-ylng1us2	103	10	of	of	IN
cord-017527-ylng1us2	103	11	cell	cell	NN
cord-017527-ylng1us2	103	12	culture	culture	NN
cord-017527-ylng1us2	103	13	.	.	.
cord-017527-ylng1us2	104	1	Diagnostic	diagnostic	JJ
cord-017527-ylng1us2	104	2	and	and	CC
cord-017527-ylng1us2	104	3	research	research	NN
cord-017527-ylng1us2	104	4	activities	activity	NNS
cord-017527-ylng1us2	104	5	involve	involve	VBP
cord-017527-ylng1us2	104	6	the	the	DT
cord-017527-ylng1us2	104	7	manipulation	manipulation	NN
cord-017527-ylng1us2	104	8	of	of	IN
cord-017527-ylng1us2	104	9	primary	primary	JJ
cord-017527-ylng1us2	104	10	cultures	culture	NNS
cord-017527-ylng1us2	104	11	or	or	CC
cord-017527-ylng1us2	104	12	cell	cell	NN
cord-017527-ylng1us2	104	13	lines	line	NNS
cord-017527-ylng1us2	104	14	as	as	RB
cord-017527-ylng1us2	104	15	well	well	RB
cord-017527-ylng1us2	104	16	as	as	IN
cord-017527-ylng1us2	104	17	continuous	continuous	JJ
cord-017527-ylng1us2	104	18	cell	cell	NN
cord-017527-ylng1us2	104	19	lines	line	NNS
cord-017527-ylng1us2	104	20	derived	derive	VBN
cord-017527-ylng1us2	104	21	from	from	IN
cord-017527-ylng1us2	104	22	primary	primary	JJ
cord-017527-ylng1us2	104	23	cultures	culture	NNS
cord-017527-ylng1us2	104	24	.	.	.
cord-017527-ylng1us2	105	1	Primary	primary	JJ
cord-017527-ylng1us2	105	2	cell	cell	NN
cord-017527-ylng1us2	105	3	cultures	culture	NNS
cord-017527-ylng1us2	105	4	and	and	CC
cord-017527-ylng1us2	105	5	cell	cell	NN
cord-017527-ylng1us2	105	6	strains	strain	NNS
cord-017527-ylng1us2	105	7	are	be	VBP
cord-017527-ylng1us2	105	8	produced	produce	VBN
cord-017527-ylng1us2	105	9	directly	directly	RB
cord-017527-ylng1us2	105	10	from	from	IN
cord-017527-ylng1us2	105	11	organs	organ	NNS
cord-017527-ylng1us2	105	12	or	or	CC
cord-017527-ylng1us2	105	13	tissues	tissue	NNS
cord-017527-ylng1us2	105	14	and	and	CC
cord-017527-ylng1us2	105	15	are	be	VBP
cord-017527-ylng1us2	105	16	often	often	RB
cord-017527-ylng1us2	105	17	the	the	DT
cord-017527-ylng1us2	105	18	most	most	RBS
cord-017527-ylng1us2	105	19	accurate	accurate	JJ
cord-017527-ylng1us2	105	20	in	in	IN
cord-017527-ylng1us2	105	21	vitro	vitro	FW
cord-017527-ylng1us2	105	22	tool	tool	NN
cord-017527-ylng1us2	105	23	for	for	IN
cord-017527-ylng1us2	105	24	reproducing	reproduce	VBG
cord-017527-ylng1us2	105	25	typical	typical	JJ
cord-017527-ylng1us2	105	26	cellular	cellular	JJ
cord-017527-ylng1us2	105	27	responses	response	NNS
cord-017527-ylng1us2	105	28	observed	observe	VBN
cord-017527-ylng1us2	105	29	in	in	IN
cord-017527-ylng1us2	105	30	vivo	vivo	NNP
cord-017527-ylng1us2	105	31	.	.	.
cord-017527-ylng1us2	106	1	However	however	RB
cord-017527-ylng1us2	106	2	,	,	,
cord-017527-ylng1us2	106	3	as	as	IN
cord-017527-ylng1us2	106	4	they	-PRON-	PRP
cord-017527-ylng1us2	106	5	are	be	VBP
cord-017527-ylng1us2	106	6	characterised	characterise	VBN
cord-017527-ylng1us2	106	7	by	by	IN
cord-017527-ylng1us2	106	8	a	a	DT
cord-017527-ylng1us2	106	9	finite	finite	JJ
cord-017527-ylng1us2	106	10	life	life	NN
cord-017527-ylng1us2	106	11	span	span	NN
cord-017527-ylng1us2	106	12	,	,	,
cord-017527-ylng1us2	106	13	the	the	DT
cord-017527-ylng1us2	106	14	time	time	NN
cord-017527-ylng1us2	106	15	available	available	JJ
cord-017527-ylng1us2	106	16	for	for	IN
cord-017527-ylng1us2	106	17	characterisation	characterisation	NN
cord-017527-ylng1us2	106	18	and	and	CC
cord-017527-ylng1us2	106	19	detection	detection	NN
cord-017527-ylng1us2	106	20	of	of	IN
cord-017527-ylng1us2	106	21	contaminating	contaminate	VBG
cord-017527-ylng1us2	106	22	agents	agent	NNS
cord-017527-ylng1us2	106	23	remains	remain	VBZ
cord-017527-ylng1us2	106	24	limited	limited	JJ
cord-017527-ylng1us2	106	25	.	.	.
cord-017527-ylng1us2	107	1	Also	also	RB
cord-017527-ylng1us2	107	2	,	,	,
cord-017527-ylng1us2	107	3	because	because	IN
cord-017527-ylng1us2	107	4	typical	typical	JJ
cord-017527-ylng1us2	107	5	cell	cell	NN
cord-017527-ylng1us2	107	6	characteristics	characteristic	NNS
cord-017527-ylng1us2	107	7	are	be	VBP
cord-017527-ylng1us2	107	8	often	often	RB
cord-017527-ylng1us2	107	9	lost	lose	VBN
cord-017527-ylng1us2	107	10	during	during	IN
cord-017527-ylng1us2	107	11	the	the	DT
cord-017527-ylng1us2	107	12	passage	passage	NN
cord-017527-ylng1us2	107	13	of	of	IN
cord-017527-ylng1us2	107	14	cells	cell	NNS
cord-017527-ylng1us2	107	15	,	,	,
cord-017527-ylng1us2	107	16	primary	primary	JJ
cord-017527-ylng1us2	107	17	cell	cell	NN
cord-017527-ylng1us2	107	18	cultures	culture	NNS
cord-017527-ylng1us2	107	19	are	be	VBP
cord-017527-ylng1us2	107	20	repeatedly	repeatedly	RB
cord-017527-ylng1us2	107	21	obtained	obtain	VBN
cord-017527-ylng1us2	107	22	from	from	IN
cord-017527-ylng1us2	107	23	fresh	fresh	JJ
cord-017527-ylng1us2	107	24	tissue	tissue	NN
cord-017527-ylng1us2	107	25	,	,	,
cord-017527-ylng1us2	107	26	resulting	result	VBG
cord-017527-ylng1us2	107	27	in	in	IN
cord-017527-ylng1us2	107	28	increasing	increase	VBG
cord-017527-ylng1us2	107	29	risks	risk	NNS
cord-017527-ylng1us2	107	30	for	for	IN
cord-017527-ylng1us2	107	31	potential	potential	JJ
cord-017527-ylng1us2	107	32	contaminating	contaminate	VBG
cord-017527-ylng1us2	107	33	pathogens	pathogen	NNS
cord-017527-ylng1us2	107	34	.	.	.
cord-017527-ylng1us2	108	1	A	a	DT
cord-017527-ylng1us2	108	2	feature	feature	NN
cord-017527-ylng1us2	108	3	that	that	WDT
cord-017527-ylng1us2	108	4	distinguishes	distinguish	VBZ
cord-017527-ylng1us2	108	5	continuous	continuous	JJ
cord-017527-ylng1us2	108	6	cell	cell	NN
cord-017527-ylng1us2	108	7	lines	line	NNS
cord-017527-ylng1us2	108	8	from	from	IN
cord-017527-ylng1us2	108	9	primary	primary	JJ
cord-017527-ylng1us2	108	10	cell	cell	NN
cord-017527-ylng1us2	108	11	cultures	culture	NNS
cord-017527-ylng1us2	108	12	is	be	VBZ
cord-017527-ylng1us2	108	13	the	the	DT
cord-017527-ylng1us2	108	14	ability	ability	NN
cord-017527-ylng1us2	108	15	to	to	TO
cord-017527-ylng1us2	108	16	survive	survive	VB
cord-017527-ylng1us2	108	17	if	if	IN
cord-017527-ylng1us2	108	18	not	not	RB
cord-017527-ylng1us2	108	19	infinitely	infinitely	RB
cord-017527-ylng1us2	108	20	,	,	,
cord-017527-ylng1us2	108	21	at	at	IN
cord-017527-ylng1us2	108	22	least	least	JJS
cord-017527-ylng1us2	108	23	for	for	IN
cord-017527-ylng1us2	108	24	a	a	DT
cord-017527-ylng1us2	108	25	great	great	JJ
cord-017527-ylng1us2	108	26	number	number	NN
cord-017527-ylng1us2	108	27	of	of	IN
cord-017527-ylng1us2	108	28	passages	passage	NNS
cord-017527-ylng1us2	108	29	.	.	.
cord-017527-ylng1us2	109	1	These	these	DT
cord-017527-ylng1us2	109	2	immortalised	immortalise	VBN
cord-017527-ylng1us2	109	3	cells	cell	NNS
cord-017527-ylng1us2	109	4	are	be	VBP
cord-017527-ylng1us2	109	5	obtained	obtain	VBN
cord-017527-ylng1us2	109	6	by	by	IN
cord-017527-ylng1us2	109	7	isolating	isolate	VBG
cord-017527-ylng1us2	109	8	cells	cell	NNS
cord-017527-ylng1us2	109	9	from	from	IN
cord-017527-ylng1us2	109	10	tumours	tumour	NNS
cord-017527-ylng1us2	109	11	,	,	,
cord-017527-ylng1us2	109	12	by	by	IN
cord-017527-ylng1us2	109	13	mutating	mutate	VBG
cord-017527-ylng1us2	109	14	primary	primary	JJ
cord-017527-ylng1us2	109	15	cells	cell	NNS
cord-017527-ylng1us2	109	16	with	with	IN
cord-017527-ylng1us2	109	17	mutagens	mutagen	NNS
cord-017527-ylng1us2	109	18	,	,	,
cord-017527-ylng1us2	109	19	by	by	IN
cord-017527-ylng1us2	109	20	using	use	VBG
cord-017527-ylng1us2	109	21	viruses	virus	NNS
cord-017527-ylng1us2	109	22	or	or	CC
cord-017527-ylng1us2	109	23	recombinant	recombinant	JJ
cord-017527-ylng1us2	109	24	DNA	dna	NN
cord-017527-ylng1us2	109	25	to	to	TO
cord-017527-ylng1us2	109	26	generate	generate	VB
cord-017527-ylng1us2	109	27	indefinitely	indefinitely	RB
cord-017527-ylng1us2	109	28	growing	grow	VBG
cord-017527-ylng1us2	109	29	cells	cell	NNS
cord-017527-ylng1us2	109	30	or	or	CC
cord-017527-ylng1us2	109	31	by	by	IN
cord-017527-ylng1us2	109	32	cell	cell	NN
cord-017527-ylng1us2	109	33	fusioning	fusioning	NN
cord-017527-ylng1us2	109	34	of	of	IN
cord-017527-ylng1us2	109	35	primary	primary	JJ
cord-017527-ylng1us2	109	36	cells	cell	NNS
cord-017527-ylng1us2	109	37	with	with	IN
cord-017527-ylng1us2	109	38	a	a	DT
cord-017527-ylng1us2	109	39	continuous	continuous	JJ
cord-017527-ylng1us2	109	40	cell	cell	NN
cord-017527-ylng1us2	109	41	line	line	NN
cord-017527-ylng1us2	109	42	.	.	.
cord-017527-ylng1us2	110	1	Due	due	IN
cord-017527-ylng1us2	110	2	to	to	IN
cord-017527-ylng1us2	110	3	their	-PRON-	PRP$
cord-017527-ylng1us2	110	4	increased	increase	VBN
cord-017527-ylng1us2	110	5	life	life	NN
cord-017527-ylng1us2	110	6	span	span	NN
cord-017527-ylng1us2	110	7	,	,	,
cord-017527-ylng1us2	110	8	the	the	DT
cord-017527-ylng1us2	110	9	time	time	NN
cord-017527-ylng1us2	110	10	left	leave	VBD
cord-017527-ylng1us2	110	11	for	for	IN
cord-017527-ylng1us2	110	12	thorough	thorough	JJ
cord-017527-ylng1us2	110	13	characterisation	characterisation	NN
cord-017527-ylng1us2	110	14	and	and	CC
cord-017527-ylng1us2	110	15	detection	detection	NN
cord-017527-ylng1us2	110	16	of	of	IN
cord-017527-ylng1us2	110	17	contaminating	contaminate	VBG
cord-017527-ylng1us2	110	18	agents	agent	NNS
cord-017527-ylng1us2	110	19	is	be	VBZ
cord-017527-ylng1us2	110	20	considerably	considerably	RB
cord-017527-ylng1us2	110	21	increased	increase	VBN
cord-017527-ylng1us2	110	22	.	.	.
cord-017527-ylng1us2	111	1	Within	within	IN
cord-017527-ylng1us2	111	2	this	this	DT
cord-017527-ylng1us2	111	3	respect	respect	NN
cord-017527-ylng1us2	111	4	,	,	,
cord-017527-ylng1us2	111	5	well	well	RB
cord-017527-ylng1us2	111	6	-	-	HYPH
cord-017527-ylng1us2	111	7	characterised	characterise	VBN
cord-017527-ylng1us2	111	8	cell	cell	NN
cord-017527-ylng1us2	111	9	lines	line	NNS
cord-017527-ylng1us2	111	10	present	present	VBP
cord-017527-ylng1us2	111	11	the	the	DT
cord-017527-ylng1us2	111	12	lowest	low	JJS
cord-017527-ylng1us2	111	13	risks	risk	NNS
cord-017527-ylng1us2	111	14	compared	compare	VBN
cord-017527-ylng1us2	111	15	to	to	IN
cord-017527-ylng1us2	111	16	primary	primary	JJ
cord-017527-ylng1us2	111	17	cultures	culture	NNS
cord-017527-ylng1us2	111	18	or	or	CC
cord-017527-ylng1us2	111	19	less	less	RBR
cord-017527-ylng1us2	111	20	characterised	characterise	VBN
cord-017527-ylng1us2	111	21	cell	cell	NN
cord-017527-ylng1us2	111	22	lines	line	NNS
cord-017527-ylng1us2	111	23	as	as	IN
cord-017527-ylng1us2	111	24	the	the	DT
cord-017527-ylng1us2	111	25	origin	origin	NN
cord-017527-ylng1us2	111	26	,	,	,
cord-017527-ylng1us2	111	27	the	the	DT
cord-017527-ylng1us2	111	28	source	source	NN
cord-017527-ylng1us2	111	29	and	and	CC
cord-017527-ylng1us2	111	30	suitability	suitability	NN
cord-017527-ylng1us2	111	31	are	be	VBP
cord-017527-ylng1us2	111	32	well	well	RB
cord-017527-ylng1us2	111	33	-	-	HYPH
cord-017527-ylng1us2	111	34	known	know	VBN
cord-017527-ylng1us2	111	35	and	and	CC
cord-017527-ylng1us2	111	36	well	well	RB
cord-017527-ylng1us2	111	37	-	-	HYPH
cord-017527-ylng1us2	111	38	defined	define	VBN
cord-017527-ylng1us2	111	39	.	.	.
cord-017527-ylng1us2	112	1	For	for	IN
cord-017527-ylng1us2	112	2	cell	cell	NN
cord-017527-ylng1us2	112	3	lines	line	NNS
cord-017527-ylng1us2	112	4	obtained	obtain	VBN
cord-017527-ylng1us2	112	5	from	from	IN
cord-017527-ylng1us2	112	6	external	external	JJ
cord-017527-ylng1us2	112	7	sources	source	NNS
cord-017527-ylng1us2	112	8	(	(	-LRB-
cord-017527-ylng1us2	112	9	e.g.	e.g.	DT
cord-017527-ylng1us2	112	10	different	different	JJ
cord-017527-ylng1us2	112	11	laboratory	laboratory	NN
cord-017527-ylng1us2	112	12	)	)	-RRB-
cord-017527-ylng1us2	112	13	,	,	,
cord-017527-ylng1us2	112	14	crosscontamination	crosscontamination	NN
cord-017527-ylng1us2	112	15	of	of	IN
cord-017527-ylng1us2	112	16	cell	cell	NN
cord-017527-ylng1us2	112	17	-	-	HYPH
cord-017527-ylng1us2	112	18	lines	line	NNS
cord-017527-ylng1us2	112	19	and/or	and/or	CC
cord-017527-ylng1us2	112	20	a	a	DT
cord-017527-ylng1us2	112	21	lack	lack	NN
cord-017527-ylng1us2	112	22	of	of	IN
cord-017527-ylng1us2	112	23	proof	proof	NN
cord-017527-ylng1us2	112	24	of	of	IN
cord-017527-ylng1us2	112	25	identity	identity	NN
cord-017527-ylng1us2	112	26	is	be	VBZ
cord-017527-ylng1us2	112	27	actually	actually	RB
cord-017527-ylng1us2	112	28	a	a	DT
cord-017527-ylng1us2	112	29	widespread	widespread	JJ
cord-017527-ylng1us2	112	30	problem	problem	NN
cord-017527-ylng1us2	112	31	(	(	-LRB-
cord-017527-ylng1us2	112	32	Buehring	buehring	FW
cord-017527-ylng1us2	112	33	et	et	FW
cord-017527-ylng1us2	112	34	al	al	NNP
cord-017527-ylng1us2	112	35	.	.	.
cord-017527-ylng1us2	112	36	2004	2004	CD
cord-017527-ylng1us2	112	37	;	;	:
cord-017527-ylng1us2	112	38	Capes	Capes	NNPS
cord-017527-ylng1us2	112	39	-	-	HYPH
cord-017527-ylng1us2	112	40	Davis	Davis	NNP
cord-017527-ylng1us2	112	41	et	et	NNP
cord-017527-ylng1us2	112	42	al	al	NNP
cord-017527-ylng1us2	112	43	.	.	NNP
cord-017527-ylng1us2	112	44	2010	2010	CD
cord-017527-ylng1us2	112	45	)	)	-RRB-
cord-017527-ylng1us2	112	46	.	.	.
cord-017527-ylng1us2	113	1	In	in	IN
cord-017527-ylng1us2	113	2	order	order	NN
cord-017527-ylng1us2	113	3	to	to	TO
cord-017527-ylng1us2	113	4	have	have	VB
cord-017527-ylng1us2	113	5	at	at	IN
cord-017527-ylng1us2	113	6	least	least	JJS
cord-017527-ylng1us2	113	7	evidence	evidence	NN
cord-017527-ylng1us2	113	8	of	of	IN
cord-017527-ylng1us2	113	9	the	the	DT
cord-017527-ylng1us2	113	10	species	specie	NNS
cord-017527-ylng1us2	113	11	of	of	IN
cord-017527-ylng1us2	113	12	origin	origin	NN
cord-017527-ylng1us2	113	13	of	of	IN
cord-017527-ylng1us2	113	14	a	a	DT
cord-017527-ylng1us2	113	15	cell	cell	NN
cord-017527-ylng1us2	113	16	line	line	NN
cord-017527-ylng1us2	113	17	and	and	CC
cord-017527-ylng1us2	113	18	to	to	TO
cord-017527-ylng1us2	113	19	be	be	VB
cord-017527-ylng1us2	113	20	able	able	JJ
cord-017527-ylng1us2	113	21	to	to	TO
cord-017527-ylng1us2	113	22	conduct	conduct	VB
cord-017527-ylng1us2	113	23	a	a	DT
cord-017527-ylng1us2	113	24	thorough	thorough	JJ
cord-017527-ylng1us2	113	25	risk	risk	NN
cord-017527-ylng1us2	113	26	assessment	assessment	NN
cord-017527-ylng1us2	113	27	,	,	,
cord-017527-ylng1us2	113	28	it	-PRON-	PRP
cord-017527-ylng1us2	113	29	may	may	MD
cord-017527-ylng1us2	113	30	be	be	VB
cord-017527-ylng1us2	113	31	necessary	necessary	JJ
cord-017527-ylng1us2	113	32	to	to	TO
cord-017527-ylng1us2	113	33	fully	fully	RB
cord-017527-ylng1us2	113	34	characterise	characterise	VB
cord-017527-ylng1us2	113	35	the	the	DT
cord-017527-ylng1us2	113	36	used	use	VBN
cord-017527-ylng1us2	113	37	cell	cell	NN
cord-017527-ylng1us2	113	38	lines	line	NNS
cord-017527-ylng1us2	113	39	.	.	.
cord-017527-ylng1us2	114	1	For	for	IN
cord-017527-ylng1us2	114	2	this	this	DT
cord-017527-ylng1us2	114	3	purpose	purpose	NN
cord-017527-ylng1us2	114	4	,	,	,
cord-017527-ylng1us2	114	5	a	a	DT
cord-017527-ylng1us2	114	6	number	number	NN
cord-017527-ylng1us2	114	7	of	of	IN
cord-017527-ylng1us2	114	8	techniques	technique	NNS
cord-017527-ylng1us2	114	9	are	be	VBP
cord-017527-ylng1us2	114	10	available	available	JJ
cord-017527-ylng1us2	114	11	such	such	JJ
cord-017527-ylng1us2	114	12	as	as	IN
cord-017527-ylng1us2	114	13	cytogenetic	cytogenetic	JJ
cord-017527-ylng1us2	114	14	analysis	analysis	NN
cord-017527-ylng1us2	114	15	,	,	,
cord-017527-ylng1us2	114	16	DNA	dna	NN
cord-017527-ylng1us2	114	17	fingerprinting	fingerprinting	NN
cord-017527-ylng1us2	114	18	,	,	,
cord-017527-ylng1us2	114	19	PCR	PCR	NNP
cord-017527-ylng1us2	114	20	,	,	,
cord-017527-ylng1us2	114	21	flow	flow	NN
cord-017527-ylng1us2	114	22	cytometry	cytometry	NN
cord-017527-ylng1us2	114	23	and	and	CC
cord-017527-ylng1us2	114	24	isoenzyme	isoenzyme	NNS
cord-017527-ylng1us2	114	25	analysis	analysis	NN
cord-017527-ylng1us2	114	26	.	.	.
cord-017527-ylng1us2	115	1	(	(	-LRB-
cord-017527-ylng1us2	115	2	Matsuo	Matsuo	NNP
cord-017527-ylng1us2	115	3	et	et	FW
cord-017527-ylng1us2	115	4	al	al	NNP
cord-017527-ylng1us2	115	5	.	.	.
cord-017527-ylng1us2	116	1	1999	1999	CD
cord-017527-ylng1us2	116	2	;	;	:
cord-017527-ylng1us2	116	3	Cabrera	Cabrera	NNP
cord-017527-ylng1us2	116	4	et	et	NNP
cord-017527-ylng1us2	116	5	al	al	NNP
cord-017527-ylng1us2	116	6	.	.	.
cord-017527-ylng1us2	116	7	2006	2006	CD
cord-017527-ylng1us2	116	8	)	)	-RRB-
cord-017527-ylng1us2	116	9	.	.	.
cord-017527-ylng1us2	117	1	Many	many	JJ
cord-017527-ylng1us2	117	2	micro	micro	NNS
cord-017527-ylng1us2	117	3	-	-	HYPH
cord-017527-ylng1us2	117	4	organisms	organism	NNS
cord-017527-ylng1us2	117	5	benefit	benefit	VBP
cord-017527-ylng1us2	117	6	from	from	IN
cord-017527-ylng1us2	117	7	a	a	DT
cord-017527-ylng1us2	117	8	cell	cell	NN
cord-017527-ylng1us2	117	9	's	's	POS
cord-017527-ylng1us2	117	10	machinery	machinery	NN
cord-017527-ylng1us2	117	11	to	to	TO
cord-017527-ylng1us2	117	12	complete	complete	VB
cord-017527-ylng1us2	117	13	their	-PRON-	PRP$
cord-017527-ylng1us2	117	14	life	life	NN
cord-017527-ylng1us2	117	15	cycles	cycle	NNS
cord-017527-ylng1us2	117	16	and	and	CC
cord-017527-ylng1us2	117	17	to	to	TO
cord-017527-ylng1us2	117	18	disseminate	disseminate	VB
cord-017527-ylng1us2	117	19	.	.	.
cord-017527-ylng1us2	118	1	Hence	hence	RB
cord-017527-ylng1us2	118	2	the	the	DT
cord-017527-ylng1us2	118	3	study	study	NN
cord-017527-ylng1us2	118	4	of	of	IN
cord-017527-ylng1us2	118	5	a	a	DT
cord-017527-ylng1us2	118	6	pathogens	pathogen	NNS
cord-017527-ylng1us2	118	7	'	'	POS
cord-017527-ylng1us2	118	8	lifecycle	lifecycle	NN
cord-017527-ylng1us2	118	9	or	or	CC
cord-017527-ylng1us2	118	10	immunity	immunity	NN
cord-017527-ylng1us2	118	11	escape	escape	NN
cord-017527-ylng1us2	118	12	mechanism	mechanism	NN
cord-017527-ylng1us2	118	13	requires	require	VBZ
cord-017527-ylng1us2	118	14	the	the	DT
cord-017527-ylng1us2	118	15	intentional	intentional	JJ
cord-017527-ylng1us2	118	16	in	in	IN
cord-017527-ylng1us2	118	17	vitro	vitro	FW
cord-017527-ylng1us2	118	18	infection	infection	NN
cord-017527-ylng1us2	118	19	of	of	IN
cord-017527-ylng1us2	118	20	animal	animal	NN
cord-017527-ylng1us2	118	21	(	(	-LRB-
cord-017527-ylng1us2	118	22	or	or	CC
cord-017527-ylng1us2	118	23	human	human	JJ
cord-017527-ylng1us2	118	24	)	)	-RRB-
cord-017527-ylng1us2	118	25	cells	cell	NNS
cord-017527-ylng1us2	118	26	.	.	.
cord-017527-ylng1us2	119	1	The	the	DT
cord-017527-ylng1us2	119	2	identification	identification	NN
cord-017527-ylng1us2	119	3	of	of	IN
cord-017527-ylng1us2	119	4	potential	potential	JJ
cord-017527-ylng1us2	119	5	hazards	hazard	NNS
cord-017527-ylng1us2	119	6	associated	associate	VBN
cord-017527-ylng1us2	119	7	with	with	IN
cord-017527-ylng1us2	119	8	infected	infected	JJ
cord-017527-ylng1us2	119	9	cell	cell	NN
cord-017527-ylng1us2	119	10	cultures	culture	NNS
cord-017527-ylng1us2	119	11	requires	require	VBZ
cord-017527-ylng1us2	119	12	a	a	DT
cord-017527-ylng1us2	119	13	consideration	consideration	NN
cord-017527-ylng1us2	119	14	of	of	IN
cord-017527-ylng1us2	119	15	the	the	DT
cord-017527-ylng1us2	119	16	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	119	17	cell	cell	NN
cord-017527-ylng1us2	119	18	properties	property	NNS
cord-017527-ylng1us2	119	19	and	and	CC
cord-017527-ylng1us2	119	20	the	the	DT
cord-017527-ylng1us2	119	21	inherent	inherent	JJ
cord-017527-ylng1us2	119	22	properties	property	NNS
cord-017527-ylng1us2	119	23	of	of	IN
cord-017527-ylng1us2	119	24	the	the	DT
cord-017527-ylng1us2	119	25	infecting	infect	VBG
cord-017527-ylng1us2	119	26	pathogen	pathogen	NN
cord-017527-ylng1us2	119	27	.	.	.
cord-017527-ylng1us2	120	1	The	the	DT
cord-017527-ylng1us2	120	2	latter	latter	JJ
cord-017527-ylng1us2	120	3	implies	imply	VBZ
cord-017527-ylng1us2	120	4	an	an	DT
cord-017527-ylng1us2	120	5	assessment	assessment	NN
cord-017527-ylng1us2	120	6	of	of	IN
cord-017527-ylng1us2	120	7	a	a	DT
cord-017527-ylng1us2	120	8	number	number	NN
cord-017527-ylng1us2	120	9	of	of	IN
cord-017527-ylng1us2	120	10	pathogen	pathogen	NN
cord-017527-ylng1us2	120	11	specific	specific	JJ
cord-017527-ylng1us2	120	12	criteria	criterion	NNS
cord-017527-ylng1us2	120	13	along	along	IN
cord-017527-ylng1us2	120	14	with	with	IN
cord-017527-ylng1us2	120	15	aspects	aspect	NNS
cord-017527-ylng1us2	120	16	such	such	JJ
cord-017527-ylng1us2	120	17	as	as	IN
cord-017527-ylng1us2	120	18	the	the	DT
cord-017527-ylng1us2	120	19	existence	existence	NN
cord-017527-ylng1us2	120	20	of	of	IN
cord-017527-ylng1us2	120	21	effective	effective	JJ
cord-017527-ylng1us2	120	22	treatment	treatment	NN
cord-017527-ylng1us2	120	23	or	or	CC
cord-017527-ylng1us2	120	24	prophylaxis	prophylaxis	NN
cord-017527-ylng1us2	120	25	.	.	.
cord-017527-ylng1us2	121	1	On	on	IN
cord-017527-ylng1us2	121	2	the	the	DT
cord-017527-ylng1us2	121	3	basis	basis	NN
cord-017527-ylng1us2	121	4	of	of	IN
cord-017527-ylng1us2	121	5	these	these	DT
cord-017527-ylng1us2	121	6	criteria	criterion	NNS
cord-017527-ylng1us2	121	7	the	the	DT
cord-017527-ylng1us2	121	8	WHO	who	WP
cord-017527-ylng1us2	121	9	defines	define	VBZ
cord-017527-ylng1us2	121	10	a	a	DT
cord-017527-ylng1us2	121	11	classification	classification	NN
cord-017527-ylng1us2	121	12	system	system	NN
cord-017527-ylng1us2	121	13	that	that	WDT
cord-017527-ylng1us2	121	14	enables	enable	VBZ
cord-017527-ylng1us2	121	15	the	the	DT
cord-017527-ylng1us2	121	16	categorisation	categorisation	NN
cord-017527-ylng1us2	121	17	of	of	IN
cord-017527-ylng1us2	121	18	micro	micro	NNS
cord-017527-ylng1us2	121	19	-	-	NNS
cord-017527-ylng1us2	121	20	organisms	organism	NNS
cord-017527-ylng1us2	121	21	into	into	IN
cord-017527-ylng1us2	121	22	four	four	CD
cord-017527-ylng1us2	121	23	risk	risk	NN
cord-017527-ylng1us2	121	24	groups	group	NNS
cord-017527-ylng1us2	121	25	(	(	-LRB-
cord-017527-ylng1us2	121	26	World	World	NNP
cord-017527-ylng1us2	121	27	Health	Health	NNP
cord-017527-ylng1us2	121	28	Organization	Organization	NNP
cord-017527-ylng1us2	121	29	2004	2004	CD
cord-017527-ylng1us2	121	30	)	)	-RRB-
cord-017527-ylng1us2	121	31	.	.	.
cord-017527-ylng1us2	122	1	A	a	DT
cord-017527-ylng1us2	122	2	fundamental	fundamental	JJ
cord-017527-ylng1us2	122	3	rule	rule	NN
cord-017527-ylng1us2	122	4	is	be	VBZ
cord-017527-ylng1us2	122	5	that	that	IN
cord-017527-ylng1us2	122	6	the	the	DT
cord-017527-ylng1us2	122	7	biological	biological	JJ
cord-017527-ylng1us2	122	8	risk	risk	NN
cord-017527-ylng1us2	122	9	of	of	IN
cord-017527-ylng1us2	122	10	infected	infected	JJ
cord-017527-ylng1us2	122	11	cell	cell	NN
cord-017527-ylng1us2	122	12	cultures	culture	NNS
cord-017527-ylng1us2	122	13	will	will	MD
cord-017527-ylng1us2	122	14	depend	depend	VB
cord-017527-ylng1us2	122	15	on	on	IN
cord-017527-ylng1us2	122	16	the	the	DT
cord-017527-ylng1us2	122	17	infecting	infect	VBG
cord-017527-ylng1us2	122	18	pathogen(s	pathogen(s	NNP
cord-017527-ylng1us2	122	19	)	)	-RRB-
cord-017527-ylng1us2	122	20	class	class	NN
cord-017527-ylng1us2	122	21	of	of	IN
cord-017527-ylng1us2	122	22	risk	risk	NN
cord-017527-ylng1us2	122	23	.	.	.
cord-017527-ylng1us2	123	1	For	for	IN
cord-017527-ylng1us2	123	2	example	example	NN
cord-017527-ylng1us2	123	3	,	,	,
cord-017527-ylng1us2	123	4	cell	cell	NN
cord-017527-ylng1us2	123	5	cultures	culture	NNS
cord-017527-ylng1us2	123	6	deliberately	deliberately	RB
cord-017527-ylng1us2	123	7	infected	infect	VBN
cord-017527-ylng1us2	123	8	with	with	IN
cord-017527-ylng1us2	123	9	Hepatitis	Hepatitis	NNP
cord-017527-ylng1us2	123	10	C	C	NNP
cord-017527-ylng1us2	123	11	virus	virus	NN
cord-017527-ylng1us2	123	12	(	(	-LRB-
cord-017527-ylng1us2	123	13	HCV	HCV	NNP
cord-017527-ylng1us2	123	14	)	)	-RRB-
cord-017527-ylng1us2	123	15	in	in	IN
cord-017527-ylng1us2	123	16	order	order	NN
cord-017527-ylng1us2	123	17	to	to	TO
cord-017527-ylng1us2	123	18	produce	produce	VB
cord-017527-ylng1us2	123	19	virus	virus	NN
cord-017527-ylng1us2	123	20	particles	particle	NNS
cord-017527-ylng1us2	123	21	are	be	VBP
cord-017527-ylng1us2	123	22	assigned	assign	VBN
cord-017527-ylng1us2	123	23	to	to	IN
cord-017527-ylng1us2	123	24	class	class	NN
cord-017527-ylng1us2	123	25	of	of	IN
cord-017527-ylng1us2	123	26	risk	risk	NN
cord-017527-ylng1us2	123	27	3	3	CD
cord-017527-ylng1us2	123	28	,	,	,
cord-017527-ylng1us2	123	29	as	as	IN
cord-017527-ylng1us2	123	30	HCV	HCV	NNP
cord-017527-ylng1us2	123	31	is	be	VBZ
cord-017527-ylng1us2	123	32	a	a	DT
cord-017527-ylng1us2	123	33	class	class	NN
cord-017527-ylng1us2	123	34	of	of	IN
cord-017527-ylng1us2	123	35	risk	risk	NN
cord-017527-ylng1us2	123	36	3	3	CD
cord-017527-ylng1us2	123	37	virus	virus	NN
cord-017527-ylng1us2	123	38	.	.	.
cord-017527-ylng1us2	124	1	Human	human	JJ
cord-017527-ylng1us2	124	2	cells	cell	NNS
cord-017527-ylng1us2	124	3	infected	infect	VBN
cord-017527-ylng1us2	124	4	with	with	IN
cord-017527-ylng1us2	124	5	an	an	DT
cord-017527-ylng1us2	124	6	airborne	airborne	JJ
cord-017527-ylng1us2	124	7	pathogen	pathogen	NN
cord-017527-ylng1us2	124	8	like	like	IN
cord-017527-ylng1us2	124	9	species	specie	NNS
cord-017527-ylng1us2	124	10	of	of	IN
cord-017527-ylng1us2	124	11	the	the	DT
cord-017527-ylng1us2	124	12	Mycobacterium	Mycobacterium	NNP
cord-017527-ylng1us2	124	13	tuberculosis	tuberculosis	NN
cord-017527-ylng1us2	124	14	complex	complex	NN
cord-017527-ylng1us2	124	15	are	be	VBP
cord-017527-ylng1us2	124	16	also	also	RB
cord-017527-ylng1us2	124	17	assigned	assign	VBN
cord-017527-ylng1us2	124	18	to	to	IN
cord-017527-ylng1us2	124	19	class	class	NN
cord-017527-ylng1us2	124	20	of	of	IN
cord-017527-ylng1us2	124	21	risk	risk	NN
cord-017527-ylng1us2	124	22	3	3	CD
cord-017527-ylng1us2	124	23	and	and	CC
cord-017527-ylng1us2	124	24	are	be	VBP
cord-017527-ylng1us2	124	25	requiring	require	VBG
cord-017527-ylng1us2	124	26	the	the	DT
cord-017527-ylng1us2	124	27	adoption	adoption	NN
cord-017527-ylng1us2	124	28	of	of	IN
cord-017527-ylng1us2	124	29	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	124	30	Level	Level	NNP
cord-017527-ylng1us2	124	31	3	3	CD
cord-017527-ylng1us2	124	32	containment	containment	NN
cord-017527-ylng1us2	124	33	.	.	.
cord-017527-ylng1us2	125	1	However	however	RB
cord-017527-ylng1us2	125	2	,	,	,
cord-017527-ylng1us2	125	3	as	as	IN
cord-017527-ylng1us2	125	4	discussed	discuss	VBN
cord-017527-ylng1us2	125	5	below	below	RB
cord-017527-ylng1us2	125	6	,	,	,
cord-017527-ylng1us2	125	7	the	the	DT
cord-017527-ylng1us2	125	8	class	class	NN
cord-017527-ylng1us2	125	9	of	of	IN
cord-017527-ylng1us2	125	10	risk	risk	NN
cord-017527-ylng1us2	125	11	to	to	TO
cord-017527-ylng1us2	125	12	which	which	WDT
cord-017527-ylng1us2	125	13	the	the	DT
cord-017527-ylng1us2	125	14	infected	infected	JJ
cord-017527-ylng1us2	125	15	cell	cell	NN
cord-017527-ylng1us2	125	16	cultures	culture	NNS
cord-017527-ylng1us2	125	17	are	be	VBP
cord-017527-ylng1us2	125	18	assigned	assign	VBN
cord-017527-ylng1us2	125	19	will	will	MD
cord-017527-ylng1us2	125	20	not	not	RB
cord-017527-ylng1us2	125	21	necessarily	necessarily	RB
cord-017527-ylng1us2	125	22	indicate	indicate	VB
cord-017527-ylng1us2	125	23	the	the	DT
cord-017527-ylng1us2	125	24	level	level	NN
cord-017527-ylng1us2	125	25	of	of	IN
cord-017527-ylng1us2	125	26	containment	containment	NN
cord-017527-ylng1us2	125	27	to	to	TO
cord-017527-ylng1us2	125	28	be	be	VB
cord-017527-ylng1us2	125	29	implemented	implement	VBN
cord-017527-ylng1us2	125	30	as	as	IN
cord-017527-ylng1us2	125	31	the	the	DT
cord-017527-ylng1us2	125	32	latter	latter	JJ
cord-017527-ylng1us2	125	33	will	will	MD
cord-017527-ylng1us2	125	34	also	also	RB
cord-017527-ylng1us2	125	35	be	be	VB
cord-017527-ylng1us2	125	36	determined	determine	VBN
cord-017527-ylng1us2	125	37	by	by	IN
cord-017527-ylng1us2	125	38	the	the	DT
cord-017527-ylng1us2	125	39	nature	nature	NN
cord-017527-ylng1us2	125	40	of	of	IN
cord-017527-ylng1us2	125	41	the	the	DT
cord-017527-ylng1us2	125	42	work	work	NN
cord-017527-ylng1us2	125	43	carried	carry	VBN
cord-017527-ylng1us2	125	44	out	out	RP
cord-017527-ylng1us2	125	45	with	with	IN
cord-017527-ylng1us2	125	46	these	these	DT
cord-017527-ylng1us2	125	47	cells	cell	NNS
cord-017527-ylng1us2	125	48	.	.	.
cord-017527-ylng1us2	126	1	An	an	DT
cord-017527-ylng1us2	126	2	example	example	NN
cord-017527-ylng1us2	126	3	is	be	VBZ
cord-017527-ylng1us2	126	4	the	the	DT
cord-017527-ylng1us2	126	5	infection	infection	NN
cord-017527-ylng1us2	126	6	of	of	IN
cord-017527-ylng1us2	126	7	bovine	bovine	JJ
cord-017527-ylng1us2	126	8	leukocytes	leukocyte	NNS
cord-017527-ylng1us2	126	9	with	with	IN
cord-017527-ylng1us2	126	10	Theileria	Theileria	NNP
cord-017527-ylng1us2	126	11	parva	parva	NNP
cord-017527-ylng1us2	126	12	,	,	,
cord-017527-ylng1us2	126	13	a	a	DT
cord-017527-ylng1us2	126	14	tick	tick	NN
cord-017527-ylng1us2	126	15	-	-	HYPH
cord-017527-ylng1us2	126	16	transmitted	transmit	VBN
cord-017527-ylng1us2	126	17	,	,	,
cord-017527-ylng1us2	126	18	intracellular	intracellular	JJ
cord-017527-ylng1us2	126	19	protozoan	protozoan	NN
cord-017527-ylng1us2	126	20	of	of	IN
cord-017527-ylng1us2	126	21	veterinary	veterinary	JJ
cord-017527-ylng1us2	126	22	importance	importance	NN
cord-017527-ylng1us2	126	23	and	and	CC
cord-017527-ylng1us2	126	24	the	the	DT
cord-017527-ylng1us2	126	25	causative	causative	JJ
cord-017527-ylng1us2	126	26	agent	agent	NN
cord-017527-ylng1us2	126	27	of	of	IN
cord-017527-ylng1us2	126	28	East	East	NNP
cord-017527-ylng1us2	126	29	Coast	Coast	NNP
cord-017527-ylng1us2	126	30	fever	fever	NN
cord-017527-ylng1us2	126	31	among	among	IN
cord-017527-ylng1us2	126	32	domestic	domestic	JJ
cord-017527-ylng1us2	126	33	livestock	livestock	NN
cord-017527-ylng1us2	126	34	.	.	.
cord-017527-ylng1us2	127	1	It	-PRON-	PRP
cord-017527-ylng1us2	127	2	is	be	VBZ
cord-017527-ylng1us2	127	3	an	an	DT
cord-017527-ylng1us2	127	4	animal	animal	NN
cord-017527-ylng1us2	127	5	pathogen	pathogen	NN
cord-017527-ylng1us2	127	6	of	of	IN
cord-017527-ylng1us2	127	7	risk	risk	NN
cord-017527-ylng1us2	127	8	group	group	NN
cord-017527-ylng1us2	127	9	3	3	CD
cord-017527-ylng1us2	127	10	,	,	,
cord-017527-ylng1us2	127	11	which	which	WDT
cord-017527-ylng1us2	127	12	is	be	VBZ
cord-017527-ylng1us2	127	13	not	not	RB
cord-017527-ylng1us2	127	14	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	127	15	to	to	IN
cord-017527-ylng1us2	127	16	humans	human	NNS
cord-017527-ylng1us2	127	17	.	.	.
cord-017527-ylng1us2	128	1	The	the	DT
cord-017527-ylng1us2	128	2	sporozoite	sporozoite	JJ
cord-017527-ylng1us2	128	3	form	form	NN
cord-017527-ylng1us2	128	4	(	(	-LRB-
cord-017527-ylng1us2	128	5	infective	infective	JJ
cord-017527-ylng1us2	128	6	form	form	NN
cord-017527-ylng1us2	128	7	)	)	-RRB-
cord-017527-ylng1us2	128	8	invades	invade	VBZ
cord-017527-ylng1us2	128	9	bovine	bovine	JJ
cord-017527-ylng1us2	128	10	lymphocytes	lymphocyte	NNS
cord-017527-ylng1us2	128	11	where	where	WRB
cord-017527-ylng1us2	128	12	it	-PRON-	PRP
cord-017527-ylng1us2	128	13	develops	develop	VBZ
cord-017527-ylng1us2	128	14	into	into	IN
cord-017527-ylng1us2	128	15	a	a	DT
cord-017527-ylng1us2	128	16	non	non	JJ
cord-017527-ylng1us2	128	17	-	-	JJ
cord-017527-ylng1us2	128	18	infective	infective	JJ
cord-017527-ylng1us2	128	19	form	form	NN
cord-017527-ylng1us2	128	20	(	(	-LRB-
cord-017527-ylng1us2	128	21	shizonts	shizont	NNS
cord-017527-ylng1us2	128	22	)	)	-RRB-
cord-017527-ylng1us2	128	23	and	and	CC
cord-017527-ylng1us2	128	24	induces	induce	VBZ
cord-017527-ylng1us2	128	25	host	host	NN
cord-017527-ylng1us2	128	26	cell	cell	NN
cord-017527-ylng1us2	128	27	transformation	transformation	NN
cord-017527-ylng1us2	128	28	and	and	CC
cord-017527-ylng1us2	128	29	clonal	clonal	JJ
cord-017527-ylng1us2	128	30	expansion	expansion	NN
cord-017527-ylng1us2	128	31	of	of	IN
cord-017527-ylng1us2	128	32	the	the	DT
cord-017527-ylng1us2	128	33	cell	cell	NN
cord-017527-ylng1us2	128	34	.	.	.
cord-017527-ylng1us2	129	1	These	these	DT
cord-017527-ylng1us2	129	2	infected	infect	VBN
cord-017527-ylng1us2	129	3	bovine	bovine	JJ
cord-017527-ylng1us2	129	4	leucocytes	leucocyte	NNS
cord-017527-ylng1us2	129	5	may	may	MD
cord-017527-ylng1us2	129	6	be	be	VB
cord-017527-ylng1us2	129	7	categorised	categorise	VBN
cord-017527-ylng1us2	129	8	under	under	IN
cord-017527-ylng1us2	129	9	class	class	NN
cord-017527-ylng1us2	129	10	of	of	IN
cord-017527-ylng1us2	129	11	risk	risk	NN
cord-017527-ylng1us2	129	12	2	2	CD
cord-017527-ylng1us2	129	13	for	for	IN
cord-017527-ylng1us2	129	14	animals	animal	NNS
cord-017527-ylng1us2	129	15	,	,	,
cord-017527-ylng1us2	129	16	while	while	IN
cord-017527-ylng1us2	129	17	the	the	DT
cord-017527-ylng1us2	129	18	biosafety	biosafety	NN
cord-017527-ylng1us2	129	19	level	level	NN
cord-017527-ylng1us2	129	20	(	(	-LRB-
cord-017527-ylng1us2	129	21	BSL1	BSL1	NNP
cord-017527-ylng1us2	129	22	or	or	CC
cord-017527-ylng1us2	129	23	2	2	LS
cord-017527-ylng1us2	129	24	)	)	-RRB-
cord-017527-ylng1us2	129	25	appropriate	appropriate	JJ
cord-017527-ylng1us2	129	26	for	for	IN
cord-017527-ylng1us2	129	27	handling	handling	NN
cord-017527-ylng1us2	129	28	is	be	VBZ
cord-017527-ylng1us2	129	29	determined	determine	VBN
cord-017527-ylng1us2	129	30	by	by	IN
cord-017527-ylng1us2	129	31	the	the	DT
cord-017527-ylng1us2	129	32	presence	presence	NN
cord-017527-ylng1us2	129	33	or	or	CC
cord-017527-ylng1us2	129	34	absence	absence	NN
cord-017527-ylng1us2	129	35	of	of	IN
cord-017527-ylng1us2	129	36	the	the	DT
cord-017527-ylng1us2	129	37	infectious	infectious	JJ
cord-017527-ylng1us2	129	38	form	form	NN
cord-017527-ylng1us2	129	39	of	of	IN
cord-017527-ylng1us2	129	40	the	the	DT
cord-017527-ylng1us2	129	41	parasites	parasite	NNS
cord-017527-ylng1us2	129	42	.	.	.
cord-017527-ylng1us2	130	1	Cell	cell	NN
cord-017527-ylng1us2	130	2	culture	culture	NN
cord-017527-ylng1us2	130	3	can	can	MD
cord-017527-ylng1us2	130	4	also	also	RB
cord-017527-ylng1us2	130	5	be	be	VB
cord-017527-ylng1us2	130	6	coupled	couple	VBN
cord-017527-ylng1us2	130	7	with	with	IN
cord-017527-ylng1us2	130	8	electron	electron	NN
cord-017527-ylng1us2	130	9	microscopy	microscopy	NN
cord-017527-ylng1us2	130	10	to	to	TO
cord-017527-ylng1us2	130	11	identify	identify	VB
cord-017527-ylng1us2	130	12	viral	viral	JJ
cord-017527-ylng1us2	130	13	diseases	disease	NNS
cord-017527-ylng1us2	130	14	of	of	IN
cord-017527-ylng1us2	130	15	unknown	unknown	JJ
cord-017527-ylng1us2	130	16	cause	cause	NN
cord-017527-ylng1us2	130	17	as	as	IN
cord-017527-ylng1us2	130	18	shown	show	VBN
cord-017527-ylng1us2	130	19	in	in	IN
cord-017527-ylng1us2	130	20	a	a	DT
cord-017527-ylng1us2	130	21	recent	recent	JJ
cord-017527-ylng1us2	130	22	study	study	NN
cord-017527-ylng1us2	130	23	published	publish	VBN
cord-017527-ylng1us2	130	24	by	by	IN
cord-017527-ylng1us2	130	25	the	the	DT
cord-017527-ylng1us2	130	26	Centers	Centers	NNPS
cord-017527-ylng1us2	130	27	for	for	IN
cord-017527-ylng1us2	130	28	Disease	Disease	NNP
cord-017527-ylng1us2	130	29	Control	Control	NNP
cord-017527-ylng1us2	130	30	and	and	CC
cord-017527-ylng1us2	130	31	Prevention	Prevention	NNP
cord-017527-ylng1us2	131	1	(	(	-LRB-
cord-017527-ylng1us2	131	2	Goldsmith	Goldsmith	NNP
cord-017527-ylng1us2	131	3	et	et	FW
cord-017527-ylng1us2	131	4	al	al	NNP
cord-017527-ylng1us2	131	5	.	.	NNP
cord-017527-ylng1us2	131	6	2013	2013	CD
cord-017527-ylng1us2	131	7	)	)	-RRB-
cord-017527-ylng1us2	131	8	.	.	.
cord-017527-ylng1us2	132	1	In	in	IN
cord-017527-ylng1us2	132	2	case	case	NN
cord-017527-ylng1us2	132	3	of	of	IN
cord-017527-ylng1us2	132	4	outbreaks	outbreak	NNS
cord-017527-ylng1us2	132	5	the	the	DT
cord-017527-ylng1us2	132	6	harvested	harvest	VBN
cord-017527-ylng1us2	132	7	tissues	tissue	NNS
cord-017527-ylng1us2	132	8	from	from	IN
cord-017527-ylng1us2	132	9	dead	dead	JJ
cord-017527-ylng1us2	132	10	or	or	CC
cord-017527-ylng1us2	132	11	living	live	VBG
cord-017527-ylng1us2	132	12	infected	infected	JJ
cord-017527-ylng1us2	132	13	patients	patient	NNS
cord-017527-ylng1us2	132	14	are	be	VBP
cord-017527-ylng1us2	132	15	inoculated	inoculate	VBN
cord-017527-ylng1us2	132	16	to	to	IN
cord-017527-ylng1us2	132	17	a	a	DT
cord-017527-ylng1us2	132	18	permissive	permissive	JJ
cord-017527-ylng1us2	132	19	cell	cell	NN
cord-017527-ylng1us2	132	20	line	line	NN
cord-017527-ylng1us2	132	21	(	(	-LRB-
cord-017527-ylng1us2	132	22	generally	generally	RB
cord-017527-ylng1us2	132	23	on	on	IN
cord-017527-ylng1us2	132	24	VERO	VERO	NNP
cord-017527-ylng1us2	132	25	E6	E6	NNP
cord-017527-ylng1us2	132	26	cells	cell	NNS
cord-017527-ylng1us2	132	27	)	)	-RRB-
cord-017527-ylng1us2	132	28	and	and	CC
cord-017527-ylng1us2	132	29	eventually	eventually	RB
cord-017527-ylng1us2	132	30	subjected	subject	VBN
cord-017527-ylng1us2	132	31	to	to	IN
cord-017527-ylng1us2	132	32	electron	electron	NN
cord-017527-ylng1us2	132	33	microscopy	microscopy	NN
cord-017527-ylng1us2	132	34	for	for	IN
cord-017527-ylng1us2	132	35	morphological	morphological	JJ
cord-017527-ylng1us2	132	36	analysis	analysis	NN
cord-017527-ylng1us2	132	37	of	of	IN
cord-017527-ylng1us2	132	38	the	the	DT
cord-017527-ylng1us2	132	39	causal	causal	JJ
cord-017527-ylng1us2	132	40	virus	virus	NN
cord-017527-ylng1us2	132	41	.	.	.
cord-017527-ylng1us2	133	1	Although	although	IN
cord-017527-ylng1us2	133	2	alternatives	alternative	NNS
cord-017527-ylng1us2	133	3	methods	method	NNS
cord-017527-ylng1us2	133	4	such	such	JJ
cord-017527-ylng1us2	133	5	as	as	IN
cord-017527-ylng1us2	133	6	high	high	JJ
cord-017527-ylng1us2	133	7	throughput	throughput	NN
cord-017527-ylng1us2	133	8	DNA	dna	NN
cord-017527-ylng1us2	133	9	sequencing	sequencing	NN
cord-017527-ylng1us2	133	10	are	be	VBP
cord-017527-ylng1us2	133	11	available	available	JJ
cord-017527-ylng1us2	133	12	to	to	TO
cord-017527-ylng1us2	133	13	identify	identify	VB
cord-017527-ylng1us2	133	14	a	a	DT
cord-017527-ylng1us2	133	15	microorganism	microorganism	NN
cord-017527-ylng1us2	133	16	without	without	IN
cord-017527-ylng1us2	133	17	a	a	DT
cord-017527-ylng1us2	133	18	prior	prior	JJ
cord-017527-ylng1us2	133	19	in	in	IN
cord-017527-ylng1us2	133	20	vitro	vitro	FW
cord-017527-ylng1us2	133	21	expansion	expansion	NN
cord-017527-ylng1us2	133	22	,	,	,
cord-017527-ylng1us2	133	23	cell	cell	NN
cord-017527-ylng1us2	133	24	culture	culture	NN
cord-017527-ylng1us2	133	25	followed	follow	VBN
cord-017527-ylng1us2	133	26	by	by	IN
cord-017527-ylng1us2	133	27	electron	electron	NN
cord-017527-ylng1us2	133	28	microscopy	microscopy	NN
cord-017527-ylng1us2	133	29	remains	remain	VBZ
cord-017527-ylng1us2	133	30	the	the	DT
cord-017527-ylng1us2	133	31	complementary	complementary	JJ
cord-017527-ylng1us2	133	32	approach	approach	NN
cord-017527-ylng1us2	133	33	of	of	IN
cord-017527-ylng1us2	133	34	choice	choice	NN
cord-017527-ylng1us2	133	35	to	to	IN
cord-017527-ylng1us2	133	36	molecular	molecular	JJ
cord-017527-ylng1us2	133	37	methods	method	NNS
cord-017527-ylng1us2	133	38	for	for	IN
cord-017527-ylng1us2	133	39	the	the	DT
cord-017527-ylng1us2	133	40	unbiased	unbiased	JJ
cord-017527-ylng1us2	133	41	diagnosis	diagnosis	NN
cord-017527-ylng1us2	133	42	of	of	IN
cord-017527-ylng1us2	133	43	ill	ill	RB
cord-017527-ylng1us2	133	44	-	-	HYPH
cord-017527-ylng1us2	133	45	defined	define	VBN
cord-017527-ylng1us2	133	46	infectious	infectious	JJ
cord-017527-ylng1us2	133	47	disease	disease	NN
cord-017527-ylng1us2	133	48	.	.	.
cord-017527-ylng1us2	134	1	Some	some	DT
cord-017527-ylng1us2	134	2	of	of	IN
cord-017527-ylng1us2	134	3	the	the	DT
cord-017527-ylng1us2	134	4	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	134	5	activities	activity	NNS
cord-017527-ylng1us2	134	6	presented	present	VBN
cord-017527-ylng1us2	134	7	by	by	IN
cord-017527-ylng1us2	134	8	the	the	DT
cord-017527-ylng1us2	134	9	authors	author	NNS
cord-017527-ylng1us2	134	10	required	require	VBD
cord-017527-ylng1us2	134	11	the	the	DT
cord-017527-ylng1us2	134	12	adoption	adoption	NN
cord-017527-ylng1us2	134	13	of	of	IN
cord-017527-ylng1us2	134	14	BSL3	BSL3	NNP
cord-017527-ylng1us2	134	15	measures	measure	NNS
cord-017527-ylng1us2	134	16	to	to	TO
cord-017527-ylng1us2	134	17	handle	handle	VB
cord-017527-ylng1us2	134	18	the	the	DT
cord-017527-ylng1us2	134	19	cell	cell	NN
cord-017527-ylng1us2	134	20	cultures	culture	NNS
cord-017527-ylng1us2	134	21	.	.	.
cord-017527-ylng1us2	135	1	It	-PRON-	PRP
cord-017527-ylng1us2	135	2	illustrates	illustrate	VBZ
cord-017527-ylng1us2	135	3	how	how	WRB
cord-017527-ylng1us2	135	4	activities	activity	NNS
cord-017527-ylng1us2	135	5	involving	involve	VBG
cord-017527-ylng1us2	135	6	the	the	DT
cord-017527-ylng1us2	135	7	in	in	FW
cord-017527-ylng1us2	135	8	vitro	vitro	FW
cord-017527-ylng1us2	135	9	amplification	amplification	NN
cord-017527-ylng1us2	135	10	of	of	IN
cord-017527-ylng1us2	135	11	unknown	unknown	JJ
cord-017527-ylng1us2	135	12	virus	virus	NN
cord-017527-ylng1us2	135	13	may	may	MD
cord-017527-ylng1us2	135	14	represent	represent	VB
cord-017527-ylng1us2	135	15	a	a	DT
cord-017527-ylng1us2	135	16	risk	risk	NN
cord-017527-ylng1us2	135	17	for	for	IN
cord-017527-ylng1us2	135	18	the	the	DT
cord-017527-ylng1us2	135	19	laboratory	laboratory	NN
cord-017527-ylng1us2	135	20	personnel	personnel	NNS
cord-017527-ylng1us2	135	21	and	and	CC
cord-017527-ylng1us2	135	22	requires	require	VBZ
cord-017527-ylng1us2	135	23	the	the	DT
cord-017527-ylng1us2	135	24	adoption	adoption	NN
cord-017527-ylng1us2	135	25	of	of	IN
cord-017527-ylng1us2	135	26	an	an	DT
cord-017527-ylng1us2	135	27	appropriate	appropriate	JJ
cord-017527-ylng1us2	135	28	containment	containment	NN
cord-017527-ylng1us2	135	29	level	level	NN
cord-017527-ylng1us2	135	30	and	and	CC
cord-017527-ylng1us2	135	31	work	work	NN
cord-017527-ylng1us2	135	32	practices	practice	NNS
cord-017527-ylng1us2	135	33	.	.	.
cord-017527-ylng1us2	136	1	Adventitious	adventitious	JJ
cord-017527-ylng1us2	136	2	contamination	contamination	NN
cord-017527-ylng1us2	136	3	of	of	IN
cord-017527-ylng1us2	136	4	cell	cell	NN
cord-017527-ylng1us2	136	5	cultures	culture	NNS
cord-017527-ylng1us2	136	6	is	be	VBZ
cord-017527-ylng1us2	136	7	a	a	DT
cord-017527-ylng1us2	136	8	major	major	JJ
cord-017527-ylng1us2	136	9	drawback	drawback	NN
cord-017527-ylng1us2	136	10	for	for	IN
cord-017527-ylng1us2	136	11	any	any	DT
cord-017527-ylng1us2	136	12	activity	activity	NN
cord-017527-ylng1us2	136	13	that	that	WDT
cord-017527-ylng1us2	136	14	involves	involve	VBZ
cord-017527-ylng1us2	136	15	cell	cell	NN
cord-017527-ylng1us2	136	16	culturing	culturing	NN
cord-017527-ylng1us2	136	17	(	(	-LRB-
cord-017527-ylng1us2	136	18	Langdon	Langdon	NNP
cord-017527-ylng1us2	136	19	2004	2004	CD
cord-017527-ylng1us2	136	20	)	)	-RRB-
cord-017527-ylng1us2	136	21	.	.	.
cord-017527-ylng1us2	137	1	Causative	causative	JJ
cord-017527-ylng1us2	137	2	agents	agent	NNS
cord-017527-ylng1us2	137	3	of	of	IN
cord-017527-ylng1us2	137	4	cell	cell	NN
cord-017527-ylng1us2	137	5	contamination	contamination	NN
cord-017527-ylng1us2	137	6	include	include	VBP
cord-017527-ylng1us2	137	7	bacteria	bacteria	NNS
cord-017527-ylng1us2	137	8	,	,	,
cord-017527-ylng1us2	137	9	fungi	fungus	NNS
cord-017527-ylng1us2	137	10	,	,	,
cord-017527-ylng1us2	137	11	mycoplasms	mycoplasms	NNP
cord-017527-ylng1us2	137	12	,	,	,
cord-017527-ylng1us2	137	13	parasites	parasite	NNS
cord-017527-ylng1us2	137	14	,	,	,
cord-017527-ylng1us2	137	15	viruses	virus	NNS
cord-017527-ylng1us2	137	16	,	,	,
cord-017527-ylng1us2	137	17	prions	prion	NNS
cord-017527-ylng1us2	137	18	and	and	CC
cord-017527-ylng1us2	137	19	even	even	RB
cord-017527-ylng1us2	137	20	other	other	JJ
cord-017527-ylng1us2	137	21	animal	animal	NN
cord-017527-ylng1us2	137	22	cells	cell	NNS
cord-017527-ylng1us2	137	23	.	.	.
cord-017527-ylng1us2	138	1	Beside	beside	IN
cord-017527-ylng1us2	138	2	the	the	DT
cord-017527-ylng1us2	138	3	fact	fact	NN
cord-017527-ylng1us2	138	4	that	that	IN
cord-017527-ylng1us2	138	5	contamination	contamination	NN
cord-017527-ylng1us2	138	6	of	of	IN
cord-017527-ylng1us2	138	7	cell	cell	NN
cord-017527-ylng1us2	138	8	cultures	culture	NNS
cord-017527-ylng1us2	138	9	may	may	MD
cord-017527-ylng1us2	138	10	place	place	VB
cord-017527-ylng1us2	138	11	experimental	experimental	JJ
cord-017527-ylng1us2	138	12	results	result	NNS
cord-017527-ylng1us2	138	13	in	in	IN
cord-017527-ylng1us2	138	14	question	question	NN
cord-017527-ylng1us2	138	15	or	or	CC
cord-017527-ylng1us2	138	16	may	may	MD
cord-017527-ylng1us2	138	17	lead	lead	VB
cord-017527-ylng1us2	138	18	to	to	IN
cord-017527-ylng1us2	138	19	the	the	DT
cord-017527-ylng1us2	138	20	loss	loss	NN
cord-017527-ylng1us2	138	21	of	of	IN
cord-017527-ylng1us2	138	22	cell	cell	NN
cord-017527-ylng1us2	138	23	cultures	culture	NNS
cord-017527-ylng1us2	138	24	,	,	,
cord-017527-ylng1us2	138	25	one	one	CD
cord-017527-ylng1us2	138	26	of	of	IN
cord-017527-ylng1us2	138	27	the	the	DT
cord-017527-ylng1us2	138	28	main	main	JJ
cord-017527-ylng1us2	138	29	biosafety	biosafety	NN
cord-017527-ylng1us2	138	30	concerns	concern	NNS
cord-017527-ylng1us2	138	31	when	when	WRB
cord-017527-ylng1us2	138	32	manipulating	manipulate	VBG
cord-017527-ylng1us2	138	33	animal	animal	NN
cord-017527-ylng1us2	138	34	cell	cell	NN
cord-017527-ylng1us2	138	35	cultures	culture	NNS
cord-017527-ylng1us2	138	36	for	for	IN
cord-017527-ylng1us2	138	37	research	research	NN
cord-017527-ylng1us2	138	38	,	,	,
cord-017527-ylng1us2	138	39	diagnosis	diagnosis	NN
cord-017527-ylng1us2	138	40	or	or	CC
cord-017527-ylng1us2	138	41	production	production	NN
cord-017527-ylng1us2	138	42	purposes	purpose	NNS
cord-017527-ylng1us2	138	43	is	be	VBZ
cord-017527-ylng1us2	138	44	the	the	DT
cord-017527-ylng1us2	138	45	fact	fact	NN
cord-017527-ylng1us2	138	46	that	that	IN
cord-017527-ylng1us2	138	47	they	-PRON-	PRP
cord-017527-ylng1us2	138	48	may	may	MD
cord-017527-ylng1us2	138	49	provide	provide	VB
cord-017527-ylng1us2	138	50	a	a	DT
cord-017527-ylng1us2	138	51	support	support	NN
cord-017527-ylng1us2	138	52	for	for	IN
cord-017527-ylng1us2	138	53	contaminating	contaminate	VBG
cord-017527-ylng1us2	138	54	agents	agent	NNS
cord-017527-ylng1us2	138	55	that	that	WDT
cord-017527-ylng1us2	138	56	cause	cause	VBP
cord-017527-ylng1us2	138	57	harm	harm	NN
cord-017527-ylng1us2	138	58	to	to	IN
cord-017527-ylng1us2	138	59	human	human	JJ
cord-017527-ylng1us2	138	60	health	health	NN
cord-017527-ylng1us2	138	61	.	.	.
cord-017527-ylng1us2	139	1	Generally	generally	RB
cord-017527-ylng1us2	139	2	,	,	,
cord-017527-ylng1us2	139	3	bacterial	bacterial	JJ
cord-017527-ylng1us2	139	4	or	or	CC
cord-017527-ylng1us2	139	5	fungal	fungal	JJ
cord-017527-ylng1us2	139	6	contamination	contamination	NN
cord-017527-ylng1us2	139	7	can	can	MD
cord-017527-ylng1us2	139	8	be	be	VB
cord-017527-ylng1us2	139	9	readily	readily	RB
cord-017527-ylng1us2	139	10	detected	detect	VBN
cord-017527-ylng1us2	139	11	because	because	IN
cord-017527-ylng1us2	139	12	of	of	IN
cord-017527-ylng1us2	139	13	their	-PRON-	PRP$
cord-017527-ylng1us2	139	14	capacity	capacity	NN
cord-017527-ylng1us2	139	15	to	to	TO
cord-017527-ylng1us2	139	16	overgrow	overgrow	VB
cord-017527-ylng1us2	139	17	cell	cell	NN
cord-017527-ylng1us2	139	18	cultures	culture	NNS
cord-017527-ylng1us2	139	19	.	.	.
cord-017527-ylng1us2	140	1	Typically	typically	RB
cord-017527-ylng1us2	140	2	,	,	,
cord-017527-ylng1us2	140	3	these	these	DT
cord-017527-ylng1us2	140	4	organisms	organism	NNS
cord-017527-ylng1us2	140	5	cause	cause	VBP
cord-017527-ylng1us2	140	6	increased	increase	VBN
cord-017527-ylng1us2	140	7	turbidity	turbidity	NN
cord-017527-ylng1us2	140	8	,	,	,
cord-017527-ylng1us2	140	9	pH	pH	NNP
cord-017527-ylng1us2	140	10	shift	shift	NN
cord-017527-ylng1us2	140	11	of	of	IN
cord-017527-ylng1us2	140	12	media	medium	NNS
cord-017527-ylng1us2	140	13	(	(	-LRB-
cord-017527-ylng1us2	140	14	change	change	NN
cord-017527-ylng1us2	140	15	in	in	IN
cord-017527-ylng1us2	140	16	media	media	NN
cord-017527-ylng1us2	140	17	colour	colour	NN
cord-017527-ylng1us2	140	18	)	)	-RRB-
cord-017527-ylng1us2	140	19	,	,	,
cord-017527-ylng1us2	140	20	slower	slow	JJR
cord-017527-ylng1us2	140	21	growth	growth	NN
cord-017527-ylng1us2	140	22	of	of	IN
cord-017527-ylng1us2	140	23	the	the	DT
cord-017527-ylng1us2	140	24	cells	cell	NNS
cord-017527-ylng1us2	140	25	and	and	CC
cord-017527-ylng1us2	140	26	cell	cell	NN
cord-017527-ylng1us2	140	27	destruction	destruction	NN
cord-017527-ylng1us2	140	28	.	.	.
cord-017527-ylng1us2	141	1	Antibiotics	antibiotic	NNS
cord-017527-ylng1us2	141	2	may	may	MD
cord-017527-ylng1us2	141	3	be	be	VB
cord-017527-ylng1us2	141	4	used	use	VBN
cord-017527-ylng1us2	141	5	to	to	TO
cord-017527-ylng1us2	141	6	prevent	prevent	VB
cord-017527-ylng1us2	141	7	cell	cell	NN
cord-017527-ylng1us2	141	8	bacterial	bacterial	JJ
cord-017527-ylng1us2	141	9	contamination	contamination	NN
cord-017527-ylng1us2	141	10	,	,	,
cord-017527-ylng1us2	141	11	however	however	RB
cord-017527-ylng1us2	141	12	,	,	,
cord-017527-ylng1us2	141	13	continuous	continuous	JJ
cord-017527-ylng1us2	141	14	use	use	NN
cord-017527-ylng1us2	141	15	of	of	IN
cord-017527-ylng1us2	141	16	antibiotics	antibiotic	NNS
cord-017527-ylng1us2	141	17	in	in	IN
cord-017527-ylng1us2	141	18	cultures	culture	NNS
cord-017527-ylng1us2	141	19	may	may	MD
cord-017527-ylng1us2	141	20	lead	lead	VB
cord-017527-ylng1us2	141	21	to	to	IN
cord-017527-ylng1us2	141	22	development	development	NN
cord-017527-ylng1us2	141	23	of	of	IN
cord-017527-ylng1us2	141	24	resistant	resistant	JJ
cord-017527-ylng1us2	141	25	organisms	organism	NNS
cord-017527-ylng1us2	141	26	with	with	IN
cord-017527-ylng1us2	141	27	slow	slow	JJ
cord-017527-ylng1us2	141	28	growing	grow	VBG
cord-017527-ylng1us2	141	29	properties	property	NNS
cord-017527-ylng1us2	141	30	,	,	,
cord-017527-ylng1us2	141	31	which	which	WDT
cord-017527-ylng1us2	141	32	are	be	VBP
cord-017527-ylng1us2	141	33	much	much	RB
cord-017527-ylng1us2	141	34	more	more	RBR
cord-017527-ylng1us2	141	35	difficult	difficult	JJ
cord-017527-ylng1us2	141	36	to	to	TO
cord-017527-ylng1us2	141	37	detect	detect	VB
cord-017527-ylng1us2	141	38	by	by	IN
cord-017527-ylng1us2	141	39	direct	direct	JJ
cord-017527-ylng1us2	141	40	visual	visual	JJ
cord-017527-ylng1us2	141	41	observation	observation	NN
cord-017527-ylng1us2	141	42	.	.	.
cord-017527-ylng1us2	142	1	Compared	compare	VBN
cord-017527-ylng1us2	142	2	to	to	IN
cord-017527-ylng1us2	142	3	bacterial	bacterial	JJ
cord-017527-ylng1us2	142	4	or	or	CC
cord-017527-ylng1us2	142	5	fungal	fungal	JJ
cord-017527-ylng1us2	142	6	infections	infection	NNS
cord-017527-ylng1us2	142	7	,	,	,
cord-017527-ylng1us2	142	8	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	142	9	contamination	contamination	NN
cord-017527-ylng1us2	142	10	gives	give	VBZ
cord-017527-ylng1us2	142	11	more	more	JJR
cord-017527-ylng1us2	142	12	problems	problem	NNS
cord-017527-ylng1us2	142	13	in	in	IN
cord-017527-ylng1us2	142	14	terms	term	NNS
cord-017527-ylng1us2	142	15	of	of	IN
cord-017527-ylng1us2	142	16	incidence	incidence	NN
cord-017527-ylng1us2	142	17	,	,	,
cord-017527-ylng1us2	142	18	detectability	detectability	NN
cord-017527-ylng1us2	142	19	,	,	,
cord-017527-ylng1us2	142	20	prevention	prevention	NN
cord-017527-ylng1us2	142	21	and	and	CC
cord-017527-ylng1us2	142	22	eradication	eradication	NN
cord-017527-ylng1us2	142	23	.	.	.
cord-017527-ylng1us2	143	1	Mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	143	2	,	,	,
cord-017527-ylng1us2	143	3	an	an	DT
cord-017527-ylng1us2	143	4	intracellular	intracellular	JJ
cord-017527-ylng1us2	143	5	bacterium	bacterium	NN
cord-017527-ylng1us2	143	6	,	,	,
cord-017527-ylng1us2	143	7	is	be	VBZ
cord-017527-ylng1us2	143	8	one	one	CD
cord-017527-ylng1us2	143	9	of	of	IN
cord-017527-ylng1us2	143	10	the	the	DT
cord-017527-ylng1us2	143	11	most	most	RBS
cord-017527-ylng1us2	143	12	common	common	JJ
cord-017527-ylng1us2	143	13	cell	cell	NN
cord-017527-ylng1us2	143	14	culture	culture	NN
cord-017527-ylng1us2	143	15	contaminants	contaminant	NNS
cord-017527-ylng1us2	143	16	.	.	.
cord-017527-ylng1us2	144	1	It	-PRON-	PRP
cord-017527-ylng1us2	144	2	may	may	MD
cord-017527-ylng1us2	144	3	go	go	VB
cord-017527-ylng1us2	144	4	unnoticed	unnoticed	JJ
cord-017527-ylng1us2	144	5	for	for	IN
cord-017527-ylng1us2	144	6	many	many	JJ
cord-017527-ylng1us2	144	7	passages	passage	NNS
cord-017527-ylng1us2	144	8	and	and	CC
cord-017527-ylng1us2	144	9	can	can	MD
cord-017527-ylng1us2	144	10	change	change	VB
cord-017527-ylng1us2	144	11	several	several	JJ
cord-017527-ylng1us2	144	12	cell	cell	NN
cord-017527-ylng1us2	144	13	properties	property	NNS
cord-017527-ylng1us2	144	14	such	such	JJ
cord-017527-ylng1us2	144	15	as	as	IN
cord-017527-ylng1us2	144	16	growth	growth	NN
cord-017527-ylng1us2	144	17	,	,	,
cord-017527-ylng1us2	144	18	metabolism	metabolism	NN
cord-017527-ylng1us2	144	19	,	,	,
cord-017527-ylng1us2	144	20	morphology	morphology	NN
cord-017527-ylng1us2	144	21	and	and	CC
cord-017527-ylng1us2	144	22	genome	genome	NN
cord-017527-ylng1us2	144	23	structure	structure	NN
cord-017527-ylng1us2	144	24	(	(	-LRB-
cord-017527-ylng1us2	144	25	Paddenberg	Paddenberg	NNP
cord-017527-ylng1us2	144	26	et	et	FW
cord-017527-ylng1us2	144	27	al	al	NNP
cord-017527-ylng1us2	144	28	.	.	.
cord-017527-ylng1us2	144	29	1996	1996	CD
cord-017527-ylng1us2	144	30	;	;	:
cord-017527-ylng1us2	144	31	McGarrity	McGarrity	NNP
cord-017527-ylng1us2	144	32	and	and	CC
cord-017527-ylng1us2	144	33	Kotani	Kotani	NNP
cord-017527-ylng1us2	144	34	1985	1985	CD
cord-017527-ylng1us2	144	35	)	)	-RRB-
cord-017527-ylng1us2	144	36	.	.	.
cord-017527-ylng1us2	145	1	It	-PRON-	PRP
cord-017527-ylng1us2	145	2	has	have	VBZ
cord-017527-ylng1us2	145	3	also	also	RB
cord-017527-ylng1us2	145	4	been	be	VBN
cord-017527-ylng1us2	145	5	reported	report	VBN
cord-017527-ylng1us2	145	6	to	to	TO
cord-017527-ylng1us2	145	7	influence	influence	VB
cord-017527-ylng1us2	145	8	the	the	DT
cord-017527-ylng1us2	145	9	yield	yield	NN
cord-017527-ylng1us2	145	10	of	of	IN
cord-017527-ylng1us2	145	11	virus	virus	NN
cord-017527-ylng1us2	145	12	production	production	NN
cord-017527-ylng1us2	145	13	in	in	IN
cord-017527-ylng1us2	145	14	infected	infected	JJ
cord-017527-ylng1us2	145	15	cells	cell	NNS
cord-017527-ylng1us2	145	16	(	(	-LRB-
cord-017527-ylng1us2	145	17	Hargreaves	Hargreaves	NNP
cord-017527-ylng1us2	145	18	and	and	CC
cord-017527-ylng1us2	145	19	Leach	Leach	NNP
cord-017527-ylng1us2	145	20	1970	1970	CD
cord-017527-ylng1us2	145	21	)	)	-RRB-
cord-017527-ylng1us2	145	22	.	.	.
cord-017527-ylng1us2	146	1	Mycoplasmal	Mycoplasmal	NNP
cord-017527-ylng1us2	146	2	contamination	contamination	NN
cord-017527-ylng1us2	146	3	is	be	VBZ
cord-017527-ylng1us2	146	4	also	also	RB
cord-017527-ylng1us2	146	5	a	a	DT
cord-017527-ylng1us2	146	6	biosafety	biosafety	NN
cord-017527-ylng1us2	146	7	concern	concern	NN
cord-017527-ylng1us2	146	8	,	,	,
cord-017527-ylng1us2	146	9	because	because	IN
cord-017527-ylng1us2	146	10	some	some	DT
cord-017527-ylng1us2	146	11	of	of	IN
cord-017527-ylng1us2	146	12	the	the	DT
cord-017527-ylng1us2	146	13	contaminating	contaminate	VBG
cord-017527-ylng1us2	146	14	Mycoplasma	Mycoplasma	NNP
cord-017527-ylng1us2	146	15	spp	spp	NNS
cord-017527-ylng1us2	146	16	.	.	.
cord-017527-ylng1us2	147	1	belong	belong	VBP
cord-017527-ylng1us2	147	2	to	to	IN
cord-017527-ylng1us2	147	3	risk	risk	NN
cord-017527-ylng1us2	147	4	group	group	NN
cord-017527-ylng1us2	147	5	2	2	CD
cord-017527-ylng1us2	147	6	.	.	.
cord-017527-ylng1us2	148	1	Together	together	RB
cord-017527-ylng1us2	148	2	with	with	IN
cord-017527-ylng1us2	148	3	M.	M.	NNP
cord-017527-ylng1us2	148	4	arginini	arginini	NNP
cord-017527-ylng1us2	148	5	,	,	,
cord-017527-ylng1us2	148	6	M.	M.	NNP
cord-017527-ylng1us2	148	7	orale	orale	NNP
cord-017527-ylng1us2	148	8	,	,	,
cord-017527-ylng1us2	148	9	M.	M.	NNP
cord-017527-ylng1us2	148	10	pirum	pirum	NNP
cord-017527-ylng1us2	148	11	and	and	CC
cord-017527-ylng1us2	148	12	M.	M.	NNP
cord-017527-ylng1us2	148	13	fermentans	fermentans	NNP
cord-017527-ylng1us2	148	14	,	,	,
cord-017527-ylng1us2	148	15	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	148	16	organisms	organism	NNS
cord-017527-ylng1us2	148	17	like	like	IN
cord-017527-ylng1us2	148	18	M.	M.	NNP
cord-017527-ylng1us2	148	19	gallisepticum	gallisepticum	NNP
cord-017527-ylng1us2	148	20	(	(	-LRB-
cord-017527-ylng1us2	148	21	risk	risk	NN
cord-017527-ylng1us2	148	22	group	group	NN
cord-017527-ylng1us2	148	23	3	3	CD
cord-017527-ylng1us2	148	24	for	for	IN
cord-017527-ylng1us2	148	25	animals	animal	NNS
cord-017527-ylng1us2	148	26	)	)	-RRB-
cord-017527-ylng1us2	148	27	,	,	,
cord-017527-ylng1us2	148	28	M.	M.	NNP
cord-017527-ylng1us2	148	29	hyorhinis	hyorhinis	NNP
cord-017527-ylng1us2	148	30	(	(	-LRB-
cord-017527-ylng1us2	148	31	risk	risk	NN
cord-017527-ylng1us2	148	32	group	group	NN
cord-017527-ylng1us2	148	33	2	2	CD
cord-017527-ylng1us2	148	34	for	for	IN
cord-017527-ylng1us2	148	35	animals	animal	NNS
cord-017527-ylng1us2	148	36	)	)	-RRB-
cord-017527-ylng1us2	148	37	,	,	,
cord-017527-ylng1us2	148	38	M.	M.	NNP
cord-017527-ylng1us2	148	39	pneumoniae	pneumoniae	NN
cord-017527-ylng1us2	148	40	and	and	CC
cord-017527-ylng1us2	148	41	M.	M.	NNP
cord-017527-ylng1us2	148	42	hominis	hominis	NN
cord-017527-ylng1us2	148	43	(	(	-LRB-
cord-017527-ylng1us2	148	44	risk	risk	NN
cord-017527-ylng1us2	148	45	group	group	NN
cord-017527-ylng1us2	148	46	2	2	CD
cord-017527-ylng1us2	148	47	for	for	IN
cord-017527-ylng1us2	148	48	humans	human	NNS
cord-017527-ylng1us2	148	49	)	)	-RRB-
cord-017527-ylng1us2	148	50	account	account	VBP
cord-017527-ylng1us2	148	51	for	for	IN
cord-017527-ylng1us2	148	52	more	more	JJR
cord-017527-ylng1us2	148	53	than	than	IN
cord-017527-ylng1us2	148	54	96	96	CD
cord-017527-ylng1us2	148	55	%	%	NN
cord-017527-ylng1us2	148	56	of	of	IN
cord-017527-ylng1us2	148	57	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	148	58	contaminants	contaminant	NNS
cord-017527-ylng1us2	148	59	in	in	IN
cord-017527-ylng1us2	148	60	cell	cell	NN
cord-017527-ylng1us2	148	61	cultures	culture	NNS
cord-017527-ylng1us2	148	62	.	.	.
cord-017527-ylng1us2	149	1	Primary	primary	JJ
cord-017527-ylng1us2	149	2	sources	source	NNS
cord-017527-ylng1us2	149	3	of	of	IN
cord-017527-ylng1us2	149	4	contamination	contamination	NN
cord-017527-ylng1us2	149	5	with	with	IN
cord-017527-ylng1us2	149	6	M.	M.	NNP
cord-017527-ylng1us2	149	7	orale	orale	NNP
cord-017527-ylng1us2	149	8	,	,	,
cord-017527-ylng1us2	149	9	M.	M.	NNP
cord-017527-ylng1us2	149	10	fermentans	fermentans	NNP
cord-017527-ylng1us2	149	11	,	,	,
cord-017527-ylng1us2	149	12	and	and	CC
cord-017527-ylng1us2	149	13	M.	M.	NNP
cord-017527-ylng1us2	149	14	hominis	hominis	NN
cord-017527-ylng1us2	149	15	in	in	IN
cord-017527-ylng1us2	149	16	the	the	DT
cord-017527-ylng1us2	149	17	laboratory	laboratory	NN
cord-017527-ylng1us2	149	18	are	be	VBP
cord-017527-ylng1us2	149	19	infected	infect	VBN
cord-017527-ylng1us2	149	20	people	people	NNS
cord-017527-ylng1us2	149	21	who	who	WP
cord-017527-ylng1us2	149	22	handle	handle	VBP
cord-017527-ylng1us2	149	23	cell	cell	NN
cord-017527-ylng1us2	149	24	cultures	culture	NNS
cord-017527-ylng1us2	149	25	and	and	CC
cord-017527-ylng1us2	149	26	suspensions	suspension	NNS
cord-017527-ylng1us2	149	27	of	of	IN
cord-017527-ylng1us2	149	28	viruses	virus	NNS
cord-017527-ylng1us2	149	29	.	.	.
cord-017527-ylng1us2	150	1	Sources	source	NNS
cord-017527-ylng1us2	150	2	of	of	IN
cord-017527-ylng1us2	150	3	M.	M.	NNP
cord-017527-ylng1us2	150	4	argini	argini	NNP
cord-017527-ylng1us2	150	5	and	and	CC
cord-017527-ylng1us2	150	6	M.	M.	NNP
cord-017527-ylng1us2	150	7	hyorhinis	hyorhinis	NNP
cord-017527-ylng1us2	150	8	are	be	VBP
cord-017527-ylng1us2	150	9	usually	usually	RB
cord-017527-ylng1us2	150	10	animal	animal	NN
cord-017527-ylng1us2	150	11	donors	donor	NNS
cord-017527-ylng1us2	150	12	of	of	IN
cord-017527-ylng1us2	150	13	tissues	tissue	NNS
cord-017527-ylng1us2	150	14	and	and	CC
cord-017527-ylng1us2	150	15	biological	biological	JJ
cord-017527-ylng1us2	150	16	constituents	constituent	NNS
cord-017527-ylng1us2	150	17	used	use	VBN
cord-017527-ylng1us2	150	18	for	for	IN
cord-017527-ylng1us2	150	19	cell	cell	NN
cord-017527-ylng1us2	150	20	culture	culture	NN
cord-017527-ylng1us2	150	21	,	,	,
cord-017527-ylng1us2	150	22	e.g.	e.g.	RB
cord-017527-ylng1us2	150	23	calf	calf	NN
cord-017527-ylng1us2	150	24	serum	serum	NN
cord-017527-ylng1us2	150	25	and	and	CC
cord-017527-ylng1us2	150	26	trypsin	trypsin	NN
cord-017527-ylng1us2	150	27	(	(	-LRB-
cord-017527-ylng1us2	150	28	Razin	Razin	NNPS
cord-017527-ylng1us2	150	29	and	and	CC
cord-017527-ylng1us2	150	30	Tully	Tully	NNP
cord-017527-ylng1us2	150	31	1995	1995	CD
cord-017527-ylng1us2	150	32	;	;	:
cord-017527-ylng1us2	150	33	Pinheiro	Pinheiro	NNP
cord-017527-ylng1us2	150	34	de	de	NNP
cord-017527-ylng1us2	150	35	Oliveira	Oliveira	NNP
cord-017527-ylng1us2	150	36	et	et	NNP
cord-017527-ylng1us2	150	37	al	al	NNP
cord-017527-ylng1us2	150	38	.	.	NNP
cord-017527-ylng1us2	150	39	2013	2013	CD
cord-017527-ylng1us2	150	40	)	)	-RRB-
cord-017527-ylng1us2	150	41	.	.	.
cord-017527-ylng1us2	151	1	It	-PRON-	PRP
cord-017527-ylng1us2	151	2	was	be	VBD
cord-017527-ylng1us2	151	3	already	already	RB
cord-017527-ylng1us2	151	4	reported	report	VBN
cord-017527-ylng1us2	151	5	that	that	IN
cord-017527-ylng1us2	151	6	the	the	DT
cord-017527-ylng1us2	151	7	contamination	contamination	NN
cord-017527-ylng1us2	151	8	of	of	IN
cord-017527-ylng1us2	151	9	cell	cell	NN
cord-017527-ylng1us2	151	10	cultures	culture	NNS
cord-017527-ylng1us2	151	11	by	by	IN
cord-017527-ylng1us2	151	12	Mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	151	13	occurs	occur	VBZ
cord-017527-ylng1us2	151	14	via	via	IN
cord-017527-ylng1us2	151	15	aerosols	aerosol	NNS
cord-017527-ylng1us2	151	16	(	(	-LRB-
cord-017527-ylng1us2	151	17	O'Connell	O'Connell	NNP
cord-017527-ylng1us2	151	18	et	et	NNP
cord-017527-ylng1us2	151	19	al	al	NNP
cord-017527-ylng1us2	151	20	.	.	.
cord-017527-ylng1us2	151	21	1964	1964	CD
cord-017527-ylng1us2	151	22	)	)	-RRB-
cord-017527-ylng1us2	151	23	.	.	.
cord-017527-ylng1us2	152	1	Viral	viral	JJ
cord-017527-ylng1us2	152	2	contamination	contamination	NN
cord-017527-ylng1us2	152	3	merits	merit	VBZ
cord-017527-ylng1us2	152	4	particular	particular	JJ
cord-017527-ylng1us2	152	5	attention	attention	NN
cord-017527-ylng1us2	152	6	because	because	IN
cord-017527-ylng1us2	152	7	infected	infected	JJ
cord-017527-ylng1us2	152	8	cells	cell	NNS
cord-017527-ylng1us2	152	9	may	may	MD
cord-017527-ylng1us2	152	10	pose	pose	VB
cord-017527-ylng1us2	152	11	a	a	DT
cord-017527-ylng1us2	152	12	serious	serious	JJ
cord-017527-ylng1us2	152	13	harm	harm	NN
cord-017527-ylng1us2	152	14	to	to	IN
cord-017527-ylng1us2	152	15	human	human	JJ
cord-017527-ylng1us2	152	16	health	health	NN
cord-017527-ylng1us2	152	17	,	,	,
cord-017527-ylng1us2	152	18	especially	especially	RB
cord-017527-ylng1us2	152	19	when	when	WRB
cord-017527-ylng1us2	152	20	infected	infected	JJ
cord-017527-ylng1us2	152	21	cells	cell	NNS
cord-017527-ylng1us2	152	22	are	be	VBP
cord-017527-ylng1us2	152	23	able	able	JJ
cord-017527-ylng1us2	152	24	to	to	TO
cord-017527-ylng1us2	152	25	release	release	VB
cord-017527-ylng1us2	152	26	infectious	infectious	JJ
cord-017527-ylng1us2	152	27	particles	particle	NNS
cord-017527-ylng1us2	152	28	.	.	.
cord-017527-ylng1us2	153	1	Human	human	JJ
cord-017527-ylng1us2	153	2	cells	cell	NNS
cord-017527-ylng1us2	153	3	may	may	MD
cord-017527-ylng1us2	153	4	be	be	VB
cord-017527-ylng1us2	153	5	infected	infect	VBN
cord-017527-ylng1us2	153	6	by	by	IN
cord-017527-ylng1us2	153	7	various	various	JJ
cord-017527-ylng1us2	153	8	viruses	virus	NNS
cord-017527-ylng1us2	153	9	like	like	IN
cord-017527-ylng1us2	153	10	hepatitis	hepatitis	NN
cord-017527-ylng1us2	153	11	viruses	virus	NNS
cord-017527-ylng1us2	153	12	,	,	,
cord-017527-ylng1us2	153	13	retroviruses	retrovirus	NNS
cord-017527-ylng1us2	153	14	,	,	,
cord-017527-ylng1us2	153	15	herpes	herpes	NN
cord-017527-ylng1us2	153	16	viruses	virus	NNS
cord-017527-ylng1us2	153	17	or	or	CC
cord-017527-ylng1us2	153	18	papillomaviruses	papillomaviruse	NNS
cord-017527-ylng1us2	153	19	.	.	.
cord-017527-ylng1us2	154	1	Although	although	IN
cord-017527-ylng1us2	154	2	cell	cell	NN
cord-017527-ylng1us2	154	3	cultures	culture	NNS
cord-017527-ylng1us2	154	4	from	from	IN
cord-017527-ylng1us2	154	5	non	non	JJ
cord-017527-ylng1us2	154	6	-	-	JJ
cord-017527-ylng1us2	154	7	human	human	JJ
cord-017527-ylng1us2	154	8	origin	origin	NN
cord-017527-ylng1us2	154	9	may	may	MD
cord-017527-ylng1us2	154	10	pose	pose	VB
cord-017527-ylng1us2	154	11	less	less	JJR
cord-017527-ylng1us2	154	12	risk	risk	NN
cord-017527-ylng1us2	154	13	,	,	,
cord-017527-ylng1us2	154	14	it	-PRON-	PRP
cord-017527-ylng1us2	154	15	should	should	MD
cord-017527-ylng1us2	154	16	be	be	VB
cord-017527-ylng1us2	154	17	emphasised	emphasise	VBN
cord-017527-ylng1us2	154	18	that	that	IN
cord-017527-ylng1us2	154	19	many	many	JJ
cord-017527-ylng1us2	154	20	viruses	virus	NNS
cord-017527-ylng1us2	154	21	have	have	VBP
cord-017527-ylng1us2	154	22	a	a	DT
cord-017527-ylng1us2	154	23	broad	broad	JJ
cord-017527-ylng1us2	154	24	host	host	NN
cord-017527-ylng1us2	154	25	range	range	NN
cord-017527-ylng1us2	154	26	and	and	CC
cord-017527-ylng1us2	154	27	can	can	MD
cord-017527-ylng1us2	154	28	cross	cross	VB
cord-017527-ylng1us2	154	29	species	species	NN
cord-017527-ylng1us2	154	30	barriers	barrier	NNS
cord-017527-ylng1us2	154	31	.	.	.
cord-017527-ylng1us2	155	1	Since	since	IN
cord-017527-ylng1us2	155	2	a	a	DT
cord-017527-ylng1us2	155	3	number	number	NN
cord-017527-ylng1us2	155	4	of	of	IN
cord-017527-ylng1us2	155	5	non	non	JJ
cord-017527-ylng1us2	155	6	-	-	JJ
cord-017527-ylng1us2	155	7	human	human	JJ
cord-017527-ylng1us2	155	8	viruses	virus	NNS
cord-017527-ylng1us2	155	9	are	be	VBP
cord-017527-ylng1us2	155	10	capable	capable	JJ
cord-017527-ylng1us2	155	11	of	of	IN
cord-017527-ylng1us2	155	12	infecting	infect	VBG
cord-017527-ylng1us2	155	13	and/or	and/or	CC
cord-017527-ylng1us2	155	14	replicating	replicate	VBG
cord-017527-ylng1us2	155	15	in	in	IN
cord-017527-ylng1us2	155	16	human	human	JJ
cord-017527-ylng1us2	155	17	cells	cell	NNS
cord-017527-ylng1us2	155	18	in	in	IN
cord-017527-ylng1us2	155	19	vitro	vitro	FW
cord-017527-ylng1us2	155	20	,	,	,
cord-017527-ylng1us2	155	21	their	-PRON-	PRP$
cord-017527-ylng1us2	155	22	possibility	possibility	NN
cord-017527-ylng1us2	155	23	to	to	TO
cord-017527-ylng1us2	155	24	infect	infect	VB
cord-017527-ylng1us2	155	25	human	human	JJ
cord-017527-ylng1us2	155	26	cells	cell	NNS
cord-017527-ylng1us2	155	27	in	in	IN
cord-017527-ylng1us2	155	28	vivo	vivo	NN
cord-017527-ylng1us2	155	29	if	if	IN
cord-017527-ylng1us2	155	30	human	human	JJ
cord-017527-ylng1us2	155	31	exposure	exposure	NN
cord-017527-ylng1us2	155	32	occurs	occur	VBZ
cord-017527-ylng1us2	155	33	should	should	MD
cord-017527-ylng1us2	155	34	be	be	VB
cord-017527-ylng1us2	155	35	carefully	carefully	RB
cord-017527-ylng1us2	155	36	considered	consider	VBN
cord-017527-ylng1us2	155	37	.	.	.
cord-017527-ylng1us2	156	1	Well	well	RB
cord-017527-ylng1us2	156	2	-	-	HYPH
cord-017527-ylng1us2	156	3	known	know	VBN
cord-017527-ylng1us2	156	4	viral	viral	JJ
cord-017527-ylng1us2	156	5	contaminants	contaminant	NNS
cord-017527-ylng1us2	156	6	of	of	IN
cord-017527-ylng1us2	156	7	primate	primate	JJ
cord-017527-ylng1us2	156	8	tissues	tissue	NNS
cord-017527-ylng1us2	156	9	or	or	CC
cord-017527-ylng1us2	156	10	cells	cell	NNS
cord-017527-ylng1us2	156	11	from	from	IN
cord-017527-ylng1us2	156	12	non	non	JJ
cord-017527-ylng1us2	156	13	-	-	JJ
cord-017527-ylng1us2	156	14	human	human	JJ
cord-017527-ylng1us2	156	15	origin	origin	NN
cord-017527-ylng1us2	156	16	that	that	WDT
cord-017527-ylng1us2	156	17	can	can	MD
cord-017527-ylng1us2	156	18	cause	cause	VB
cord-017527-ylng1us2	156	19	human	human	JJ
cord-017527-ylng1us2	156	20	disease	disease	NN
cord-017527-ylng1us2	156	21	are	be	VBP
cord-017527-ylng1us2	156	22	listed	list	VBN
cord-017527-ylng1us2	156	23	in	in	IN
cord-017527-ylng1us2	156	24	Table	Table	NNP
cord-017527-ylng1us2	156	25	22	22	CD
cord-017527-ylng1us2	156	26	.1	.1	NNS
cord-017527-ylng1us2	156	27	.	.	.
cord-017527-ylng1us2	157	1	While	while	IN
cord-017527-ylng1us2	157	2	contamination	contamination	NN
cord-017527-ylng1us2	157	3	with	with	IN
cord-017527-ylng1us2	157	4	some	some	DT
cord-017527-ylng1us2	157	5	viruses	virus	NNS
cord-017527-ylng1us2	157	6	may	may	MD
cord-017527-ylng1us2	157	7	be	be	VB
cord-017527-ylng1us2	157	8	associated	associate	VBN
cord-017527-ylng1us2	157	9	with	with	IN
cord-017527-ylng1us2	157	10	changes	change	NNS
cord-017527-ylng1us2	157	11	in	in	IN
cord-017527-ylng1us2	157	12	cell	cell	NN
cord-017527-ylng1us2	157	13	morphology	morphology	NN
cord-017527-ylng1us2	157	14	or	or	CC
cord-017527-ylng1us2	157	15	behaviour	behaviour	NN
cord-017527-ylng1us2	157	16	-such	-such	:
cord-017527-ylng1us2	157	17	as	as	IN
cord-017527-ylng1us2	157	18	the	the	DT
cord-017527-ylng1us2	157	19	formation	formation	NN
cord-017527-ylng1us2	157	20	of	of	IN
cord-017527-ylng1us2	157	21	syncytia	syncytia	NN
cord-017527-ylng1us2	157	22	(	(	-LRB-
cord-017527-ylng1us2	157	23	HIV	HIV	NNP
cord-017527-ylng1us2	157	24	,	,	,
cord-017527-ylng1us2	157	25	herpes	herpes	NN
cord-017527-ylng1us2	157	26	viruses	virus	NNS
cord-017527-ylng1us2	157	27	)	)	-RRB-
cord-017527-ylng1us2	157	28	,	,	,
cord-017527-ylng1us2	157	29	swelling	swelling	NN
cord-017527-ylng1us2	157	30	of	of	IN
cord-017527-ylng1us2	157	31	cells	cell	NNS
cord-017527-ylng1us2	157	32	(	(	-LRB-
cord-017527-ylng1us2	157	33	adenoviruses	adenovirus	NNS
cord-017527-ylng1us2	157	34	)	)	-RRB-
cord-017527-ylng1us2	157	35	or	or	CC
cord-017527-ylng1us2	157	36	haemagglutination	haemagglutination	NN
cord-017527-ylng1us2	157	37	or	or	CC
cord-017527-ylng1us2	157	38	haemadsorption	haemadsorption	NN
cord-017527-ylng1us2	157	39	-viral	-viral	JJ
cord-017527-ylng1us2	157	40	contamination	contamination	NN
cord-017527-ylng1us2	157	41	may	may	MD
cord-017527-ylng1us2	157	42	be	be	VB
cord-017527-ylng1us2	157	43	harder	hard	JJR
cord-017527-ylng1us2	157	44	to	to	TO
cord-017527-ylng1us2	157	45	detect	detect	VB
cord-017527-ylng1us2	157	46	when	when	WRB
cord-017527-ylng1us2	157	47	cytopathic	cytopathic	JJ
cord-017527-ylng1us2	157	48	effects	effect	NNS
cord-017527-ylng1us2	157	49	remain	remain	VBP
cord-017527-ylng1us2	157	50	absent	absent	JJ
cord-017527-ylng1us2	157	51	.	.	.
cord-017527-ylng1us2	158	1	Viral	viral	JJ
cord-017527-ylng1us2	158	2	contamination	contamination	NN
cord-017527-ylng1us2	158	3	could	could	MD
cord-017527-ylng1us2	158	4	also	also	RB
cord-017527-ylng1us2	158	5	trigger	trigger	VB
cord-017527-ylng1us2	158	6	adverse	adverse	JJ
cord-017527-ylng1us2	158	7	effects	effect	NNS
cord-017527-ylng1us2	158	8	as	as	IN
cord-017527-ylng1us2	158	9	a	a	DT
cord-017527-ylng1us2	158	10	result	result	NN
cord-017527-ylng1us2	158	11	of	of	IN
cord-017527-ylng1us2	158	12	recombination	recombination	NN
cord-017527-ylng1us2	158	13	events	event	NNS
cord-017527-ylng1us2	158	14	or	or	CC
cord-017527-ylng1us2	158	15	phenotypic	phenotypic	VB
cord-017527-ylng1us2	158	16	mixing	mix	VBG
cord-017527-ylng1us2	158	17	between	between	IN
cord-017527-ylng1us2	158	18	contaminating	contaminate	VBG
cord-017527-ylng1us2	158	19	components	component	NNS
cord-017527-ylng1us2	158	20	and	and	CC
cord-017527-ylng1us2	158	21	experimentally	experimentally	RB
cord-017527-ylng1us2	158	22	introduced	introduce	VBN
cord-017527-ylng1us2	158	23	agents	agent	NNS
cord-017527-ylng1us2	158	24	,	,	,
cord-017527-ylng1us2	158	25	creating	create	VBG
cord-017527-ylng1us2	158	26	agents	agent	NNS
cord-017527-ylng1us2	158	27	with	with	IN
cord-017527-ylng1us2	158	28	new	new	JJ
cord-017527-ylng1us2	158	29	properties	property	NNS
cord-017527-ylng1us2	158	30	.	.	.
cord-017527-ylng1us2	159	1	For	for	IN
cord-017527-ylng1us2	159	2	example	example	NN
cord-017527-ylng1us2	159	3	,	,	,
cord-017527-ylng1us2	159	4	experimental	experimental	JJ
cord-017527-ylng1us2	159	5	results	result	NNS
cord-017527-ylng1us2	159	6	suggested	suggest	VBD
cord-017527-ylng1us2	159	7	that	that	IN
cord-017527-ylng1us2	159	8	HTLV	HTLV	NNP
cord-017527-ylng1us2	159	9	-	-	HYPH
cord-017527-ylng1us2	159	10	I	I	NNP
cord-017527-ylng1us2	159	11	or	or	CC
cord-017527-ylng1us2	159	12	HTLV	HTLV	NNP
cord-017527-ylng1us2	159	13	-	-	HYPH
cord-017527-ylng1us2	159	14	II	II	NNP
cord-017527-ylng1us2	159	15	undergo	undergo	VBP
cord-017527-ylng1us2	159	16	phenotypic	phenotypic	NN
cord-017527-ylng1us2	159	17	mixing	mix	VBG
cord-017527-ylng1us2	159	18	with	with	IN
cord-017527-ylng1us2	159	19	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	159	20	in	in	IN
cord-017527-ylng1us2	159	21	HTLV	HTLV	NNP
cord-017527-ylng1us2	159	22	/	/	SYM
cord-017527-ylng1us2	159	23	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	159	24	co	co	VBD
cord-017527-ylng1us2	159	25	-	-	JJ
cord-017527-ylng1us2	159	26	infected	infected	JJ
cord-017527-ylng1us2	159	27	cells	cell	NNS
cord-017527-ylng1us2	159	28	,	,	,
cord-017527-ylng1us2	159	29	leading	lead	VBG
cord-017527-ylng1us2	159	30	to	to	IN
cord-017527-ylng1us2	159	31	an	an	DT
cord-017527-ylng1us2	159	32	increase	increase	NN
cord-017527-ylng1us2	159	33	of	of	IN
cord-017527-ylng1us2	159	34	the	the	DT
cord-017527-ylng1us2	159	35	pathogenicity	pathogenicity	NN
cord-017527-ylng1us2	159	36	of	of	IN
cord-017527-ylng1us2	159	37	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	159	38	by	by	IN
cord-017527-ylng1us2	159	39	broadening	broaden	VBG
cord-017527-ylng1us2	159	40	the	the	DT
cord-017527-ylng1us2	159	41	spectrum	spectrum	NN
cord-017527-ylng1us2	159	42	of	of	IN
cord-017527-ylng1us2	159	43	its	-PRON-	PRP$
cord-017527-ylng1us2	159	44	cellular	cellular	JJ
cord-017527-ylng1us2	159	45	tropism	tropism	NN
cord-017527-ylng1us2	159	46	to	to	IN
cord-017527-ylng1us2	159	47	CD4	CD4	NNP
cord-017527-ylng1us2	159	48	negative	negative	JJ
cord-017527-ylng1us2	159	49	cells	cell	NNS
cord-017527-ylng1us2	159	50	(	(	-LRB-
cord-017527-ylng1us2	159	51	Lusso	Lusso	NNP
cord-017527-ylng1us2	159	52	et	et	FW
cord-017527-ylng1us2	159	53	al	al	NNP
cord-017527-ylng1us2	159	54	.	.	NNP
cord-017527-ylng1us2	159	55	1990	1990	CD
cord-017527-ylng1us2	159	56	)	)	-RRB-
cord-017527-ylng1us2	159	57	.	.	.
cord-017527-ylng1us2	160	1	Another	another	DT
cord-017527-ylng1us2	160	2	example	example	NN
cord-017527-ylng1us2	160	3	is	be	VBZ
cord-017527-ylng1us2	160	4	the	the	DT
cord-017527-ylng1us2	160	5	contamination	contamination	NN
cord-017527-ylng1us2	160	6	of	of	IN
cord-017527-ylng1us2	160	7	murine	murine	JJ
cord-017527-ylng1us2	160	8	cell	cell	NN
cord-017527-ylng1us2	160	9	cultures	culture	NNS
cord-017527-ylng1us2	160	10	by	by	IN
cord-017527-ylng1us2	160	11	Lymphocytic	lymphocytic	JJ
cord-017527-ylng1us2	160	12	choriomeningitis	choriomeningitis	NN
cord-017527-ylng1us2	160	13	virus	virus	NN
cord-017527-ylng1us2	160	14	(	(	-LRB-
cord-017527-ylng1us2	160	15	LCMV	LCMV	NNP
cord-017527-ylng1us2	160	16	)	)	-RRB-
cord-017527-ylng1us2	160	17	.	.	.
cord-017527-ylng1us2	161	1	LCMV	LCMV	NNP
cord-017527-ylng1us2	161	2	is	be	VBZ
cord-017527-ylng1us2	161	3	an	an	DT
cord-017527-ylng1us2	161	4	arenavirus	arenavirus	NN
cord-017527-ylng1us2	161	5	that	that	WDT
cord-017527-ylng1us2	161	6	establishes	establish	VBZ
cord-017527-ylng1us2	161	7	a	a	DT
cord-017527-ylng1us2	161	8	silent	silent	JJ
cord-017527-ylng1us2	161	9	,	,	,
cord-017527-ylng1us2	161	10	chronic	chronic	JJ
cord-017527-ylng1us2	161	11	infection	infection	NN
cord-017527-ylng1us2	161	12	in	in	IN
cord-017527-ylng1us2	161	13	mice	mouse	NNS
cord-017527-ylng1us2	161	14	but	but	CC
cord-017527-ylng1us2	161	15	causes	cause	VBZ
cord-017527-ylng1us2	161	16	aseptic	aseptic	JJ
cord-017527-ylng1us2	161	17	meningitis	meningitis	NN
cord-017527-ylng1us2	161	18	,	,	,
cord-017527-ylng1us2	161	19	encephalitis	encephalitis	NN
cord-017527-ylng1us2	161	20	or	or	CC
cord-017527-ylng1us2	161	21	meningoencephalitis	meningoencephalitis	NN
cord-017527-ylng1us2	161	22	to	to	IN
cord-017527-ylng1us2	161	23	humans	human	NNS
cord-017527-ylng1us2	161	24	.	.	.
cord-017527-ylng1us2	162	1	The	the	DT
cord-017527-ylng1us2	162	2	significance	significance	NN
cord-017527-ylng1us2	162	3	of	of	IN
cord-017527-ylng1us2	162	4	LCMV	LCMV	NNP
cord-017527-ylng1us2	162	5	contamination	contamination	NN
cord-017527-ylng1us2	162	6	has	have	VBZ
cord-017527-ylng1us2	162	7	been	be	VBN
cord-017527-ylng1us2	162	8	reinforced	reinforce	VBN
cord-017527-ylng1us2	162	9	by	by	IN
cord-017527-ylng1us2	162	10	the	the	DT
cord-017527-ylng1us2	162	11	description	description	NN
cord-017527-ylng1us2	162	12	of	of	IN
cord-017527-ylng1us2	162	13	cases	case	NNS
cord-017527-ylng1us2	162	14	of	of	IN
cord-017527-ylng1us2	162	15	laboratory	laboratory	NN
cord-017527-ylng1us2	162	16	-	-	HYPH
cord-017527-ylng1us2	162	17	acquired	acquire	VBN
cord-017527-ylng1us2	162	18	LCMV	LCMV	NNP
cord-017527-ylng1us2	162	19	infections	infection	NNS
cord-017527-ylng1us2	162	20	arising	arise	VBG
cord-017527-ylng1us2	162	21	from	from	IN
cord-017527-ylng1us2	162	22	contaminated	contaminate	VBN
cord-017527-ylng1us2	162	23	murine	murine	JJ
cord-017527-ylng1us2	162	24	tumour	tumour	NN
cord-017527-ylng1us2	162	25	cell	cell	NN
cord-017527-ylng1us2	162	26	lines	line	NNS
cord-017527-ylng1us2	162	27	(	(	-LRB-
cord-017527-ylng1us2	162	28	Mahy	Mahy	NNP
cord-017527-ylng1us2	162	29	et	et	FW
cord-017527-ylng1us2	162	30	al	al	NNP
cord-017527-ylng1us2	162	31	.	.	NNP
cord-017527-ylng1us2	162	32	1991	1991	CD
cord-017527-ylng1us2	162	33	)	)	-RRB-
cord-017527-ylng1us2	162	34	.	.	.
cord-017527-ylng1us2	163	1	Manipulation	manipulation	NN
cord-017527-ylng1us2	163	2	of	of	IN
cord-017527-ylng1us2	163	3	LCMV	LCMV	NNP
cord-017527-ylng1us2	163	4	infected	infect	VBN
cord-017527-ylng1us2	163	5	material	material	NN
cord-017527-ylng1us2	163	6	or	or	CC
cord-017527-ylng1us2	163	7	material	material	NN
cord-017527-ylng1us2	163	8	with	with	IN
cord-017527-ylng1us2	163	9	an	an	DT
cord-017527-ylng1us2	163	10	increased	increase	VBN
cord-017527-ylng1us2	163	11	likelihood	likelihood	NN
cord-017527-ylng1us2	163	12	of	of	IN
cord-017527-ylng1us2	163	13	LCMV	LCMV	NNP
cord-017527-ylng1us2	163	14	contamination	contamination	NN
cord-017527-ylng1us2	163	15	necessitates	necessitate	VBZ
cord-017527-ylng1us2	163	16	the	the	DT
cord-017527-ylng1us2	163	17	Whitley	Whitley	NNP
cord-017527-ylng1us2	163	18	(	(	-LRB-
cord-017527-ylng1us2	163	19	2001	2001	CD
cord-017527-ylng1us2	163	20	)	)	-RRB-
cord-017527-ylng1us2	163	21	Papovaviruses	Papovaviruses	NNP
cord-017527-ylng1us2	163	22	2	2	CD
cord-017527-ylng1us2	163	23	Butel	Butel	NNP
cord-017527-ylng1us2	163	24	(	(	-LRB-
cord-017527-ylng1us2	164	1	Adventitious	adventitious	JJ
cord-017527-ylng1us2	164	2	contamination	contamination	NN
cord-017527-ylng1us2	164	3	with	with	IN
cord-017527-ylng1us2	164	4	parasites	parasite	NNS
cord-017527-ylng1us2	164	5	may	may	MD
cord-017527-ylng1us2	164	6	be	be	VB
cord-017527-ylng1us2	164	7	an	an	DT
cord-017527-ylng1us2	164	8	issue	issue	NN
cord-017527-ylng1us2	164	9	when	when	WRB
cord-017527-ylng1us2	164	10	handling	handle	VBG
cord-017527-ylng1us2	164	11	primary	primary	JJ
cord-017527-ylng1us2	164	12	cell	cell	NN
cord-017527-ylng1us2	164	13	or	or	CC
cord-017527-ylng1us2	164	14	organ	organ	NN
cord-017527-ylng1us2	164	15	cultures	culture	NNS
cord-017527-ylng1us2	164	16	originating	originate	VBG
cord-017527-ylng1us2	164	17	from	from	IN
cord-017527-ylng1us2	164	18	a	a	DT
cord-017527-ylng1us2	164	19	donor	donor	NN
cord-017527-ylng1us2	164	20	organism	organism	NN
cord-017527-ylng1us2	164	21	that	that	WDT
cord-017527-ylng1us2	164	22	is	be	VBZ
cord-017527-ylng1us2	164	23	known	know	VBN
cord-017527-ylng1us2	164	24	or	or	CC
cord-017527-ylng1us2	164	25	suspected	suspect	VBN
cord-017527-ylng1us2	164	26	to	to	TO
cord-017527-ylng1us2	164	27	be	be	VB
cord-017527-ylng1us2	164	28	infected	infect	VBN
cord-017527-ylng1us2	164	29	with	with	IN
cord-017527-ylng1us2	164	30	a	a	DT
cord-017527-ylng1us2	164	31	specific	specific	JJ
cord-017527-ylng1us2	164	32	parasite	parasite	NN
cord-017527-ylng1us2	164	33	.	.	.
cord-017527-ylng1us2	165	1	As	as	IN
cord-017527-ylng1us2	165	2	the	the	DT
cord-017527-ylng1us2	165	3	life	life	NN
cord-017527-ylng1us2	165	4	cycle	cycle	NN
cord-017527-ylng1us2	165	5	of	of	IN
cord-017527-ylng1us2	165	6	most	most	JJS
cord-017527-ylng1us2	165	7	parasites	parasite	NNS
cord-017527-ylng1us2	165	8	comprises	comprise	VBZ
cord-017527-ylng1us2	165	9	distinct	distinct	JJ
cord-017527-ylng1us2	165	10	developmental	developmental	JJ
cord-017527-ylng1us2	165	11	stages	stage	NNS
cord-017527-ylng1us2	165	12	,	,	,
cord-017527-ylng1us2	165	13	transmission	transmission	NN
cord-017527-ylng1us2	165	14	and	and	CC
cord-017527-ylng1us2	165	15	survival	survival	NN
cord-017527-ylng1us2	165	16	of	of	IN
cord-017527-ylng1us2	165	17	the	the	DT
cord-017527-ylng1us2	165	18	parasite	parasite	NN
cord-017527-ylng1us2	165	19	will	will	MD
cord-017527-ylng1us2	165	20	strongly	strongly	RB
cord-017527-ylng1us2	165	21	depend	depend	VB
cord-017527-ylng1us2	165	22	on	on	IN
cord-017527-ylng1us2	165	23	the	the	DT
cord-017527-ylng1us2	165	24	ability	ability	NN
cord-017527-ylng1us2	165	25	of	of	IN
cord-017527-ylng1us2	165	26	the	the	DT
cord-017527-ylng1us2	165	27	invasive	invasive	JJ
cord-017527-ylng1us2	165	28	stage	stage	NN
cord-017527-ylng1us2	165	29	to	to	TO
cord-017527-ylng1us2	165	30	recognize	recognize	VB
cord-017527-ylng1us2	165	31	and	and	CC
cord-017527-ylng1us2	165	32	invade	invade	VB
cord-017527-ylng1us2	165	33	specific	specific	JJ
cord-017527-ylng1us2	165	34	host	host	NN
cord-017527-ylng1us2	165	35	cells	cell	NNS
cord-017527-ylng1us2	165	36	.	.	.
cord-017527-ylng1us2	166	1	But	but	CC
cord-017527-ylng1us2	166	2	even	even	RB
cord-017527-ylng1us2	166	3	with	with	IN
cord-017527-ylng1us2	166	4	cells	cell	NNS
cord-017527-ylng1us2	166	5	developing	develop	VBG
cord-017527-ylng1us2	166	6	the	the	DT
cord-017527-ylng1us2	166	7	non	non	JJ
cord-017527-ylng1us2	166	8	-	-	JJ
cord-017527-ylng1us2	166	9	infectious	infectious	JJ
cord-017527-ylng1us2	166	10	form	form	NN
cord-017527-ylng1us2	166	11	of	of	IN
cord-017527-ylng1us2	166	12	parasites	parasite	NNS
cord-017527-ylng1us2	166	13	,	,	,
cord-017527-ylng1us2	166	14	possible	possible	JJ
cord-017527-ylng1us2	166	15	harmful	harmful	JJ
cord-017527-ylng1us2	166	16	effects	effect	NNS
cord-017527-ylng1us2	166	17	remain	remain	VBP
cord-017527-ylng1us2	166	18	to	to	TO
cord-017527-ylng1us2	166	19	be	be	VB
cord-017527-ylng1us2	166	20	considered	consider	VBN
cord-017527-ylng1us2	166	21	since	since	IN
cord-017527-ylng1us2	166	22	natural	natural	JJ
cord-017527-ylng1us2	166	23	modes	mode	NNS
cord-017527-ylng1us2	166	24	of	of	IN
cord-017527-ylng1us2	166	25	transmission	transmission	NN
cord-017527-ylng1us2	166	26	could	could	MD
cord-017527-ylng1us2	166	27	be	be	VB
cord-017527-ylng1us2	166	28	bypassed	bypass	VBN
cord-017527-ylng1us2	166	29	during	during	IN
cord-017527-ylng1us2	166	30	the	the	DT
cord-017527-ylng1us2	166	31	manipulation	manipulation	NN
cord-017527-ylng1us2	166	32	of	of	IN
cord-017527-ylng1us2	166	33	infected	infected	JJ
cord-017527-ylng1us2	166	34	cells	cell	NNS
cord-017527-ylng1us2	166	35	.	.	.
cord-017527-ylng1us2	167	1	It	-PRON-	PRP
cord-017527-ylng1us2	167	2	is	be	VBZ
cord-017527-ylng1us2	167	3	recognised	recognise	VBN
cord-017527-ylng1us2	167	4	that	that	IN
cord-017527-ylng1us2	167	5	most	most	JJS
cord-017527-ylng1us2	167	6	of	of	IN
cord-017527-ylng1us2	167	7	the	the	DT
cord-017527-ylng1us2	167	8	parasitic	parasitic	JJ
cord-017527-ylng1us2	167	9	laboratory	laboratory	NN
cord-017527-ylng1us2	167	10	acquired	acquire	VBD
cord-017527-ylng1us2	168	1	infections	infection	NNS
cord-017527-ylng1us2	168	2	are	be	VBP
cord-017527-ylng1us2	168	3	caused	cause	VBN
cord-017527-ylng1us2	168	4	by	by	IN
cord-017527-ylng1us2	168	5	needle	needle	NN
cord-017527-ylng1us2	168	6	stick	stick	NN
cord-017527-ylng1us2	168	7	injuries	injury	NNS
cord-017527-ylng1us2	168	8	(	(	-LRB-
cord-017527-ylng1us2	168	9	Herwaldt	Herwaldt	NNP
cord-017527-ylng1us2	168	10	2001	2001	CD
cord-017527-ylng1us2	168	11	)	)	-RRB-
cord-017527-ylng1us2	168	12	.	.	.
cord-017527-ylng1us2	169	1	Finally	finally	RB
cord-017527-ylng1us2	169	2	,	,	,
cord-017527-ylng1us2	169	3	the	the	DT
cord-017527-ylng1us2	169	4	use	use	NN
cord-017527-ylng1us2	169	5	of	of	IN
cord-017527-ylng1us2	169	6	bovine	bovine	NN
cord-017527-ylng1us2	169	7	-	-	HYPH
cord-017527-ylng1us2	169	8	derived	derive	VBN
cord-017527-ylng1us2	169	9	products	product	NNS
cord-017527-ylng1us2	169	10	as	as	IN
cord-017527-ylng1us2	169	11	tissue	tissue	NN
cord-017527-ylng1us2	169	12	culture	culture	NN
cord-017527-ylng1us2	169	13	supplements	supplement	NNS
cord-017527-ylng1us2	169	14	may	may	MD
cord-017527-ylng1us2	169	15	also	also	RB
cord-017527-ylng1us2	169	16	lead	lead	VB
cord-017527-ylng1us2	169	17	to	to	IN
cord-017527-ylng1us2	169	18	the	the	DT
cord-017527-ylng1us2	169	19	contamination	contamination	NN
cord-017527-ylng1us2	169	20	with	with	IN
cord-017527-ylng1us2	169	21	unconventional	unconventional	JJ
cord-017527-ylng1us2	169	22	agents	agent	NNS
cord-017527-ylng1us2	169	23	that	that	WDT
cord-017527-ylng1us2	169	24	cause	cause	VBP
cord-017527-ylng1us2	169	25	transmissible	transmissible	JJ
cord-017527-ylng1us2	169	26	spongiform	spongiform	JJ
cord-017527-ylng1us2	169	27	encephalopathies	encephalopathy	NNS
cord-017527-ylng1us2	169	28	(	(	-LRB-
cord-017527-ylng1us2	169	29	TSE	TSE	NNP
cord-017527-ylng1us2	169	30	)	)	-RRB-
cord-017527-ylng1us2	169	31	,	,	,
cord-017527-ylng1us2	169	32	the	the	DT
cord-017527-ylng1us2	169	33	so	so	RB
cord-017527-ylng1us2	169	34	-	-	HYPH
cord-017527-ylng1us2	169	35	called	call	VBN
cord-017527-ylng1us2	169	36	prions	prion	NNS
cord-017527-ylng1us2	169	37	(	(	-LRB-
cord-017527-ylng1us2	169	38	Solassol	Solassol	NNP
cord-017527-ylng1us2	169	39	et	et	FW
cord-017527-ylng1us2	169	40	al	al	NNP
cord-017527-ylng1us2	169	41	.	.	NNP
cord-017527-ylng1us2	169	42	2003	2003	CD
cord-017527-ylng1us2	169	43	;	;	:
cord-017527-ylng1us2	169	44	Cronier	Cronier	NNP
cord-017527-ylng1us2	169	45	et	et	NNP
cord-017527-ylng1us2	169	46	al	al	NNP
cord-017527-ylng1us2	169	47	.	.	.
cord-017527-ylng1us2	169	48	2004	2004	CD
cord-017527-ylng1us2	169	49	;	;	:
cord-017527-ylng1us2	169	50	Vorberg	Vorberg	NNP
cord-017527-ylng1us2	169	51	et	et	NNP
cord-017527-ylng1us2	169	52	al	al	NNP
cord-017527-ylng1us2	169	53	.	.	.
cord-017527-ylng1us2	169	54	2004	2004	CD
cord-017527-ylng1us2	169	55	)	)	-RRB-
cord-017527-ylng1us2	169	56	.	.	.
cord-017527-ylng1us2	170	1	Contrary	contrary	JJ
cord-017527-ylng1us2	170	2	to	to	IN
cord-017527-ylng1us2	170	3	the	the	DT
cord-017527-ylng1us2	170	4	majority	majority	NN
cord-017527-ylng1us2	170	5	of	of	IN
cord-017527-ylng1us2	170	6	the	the	DT
cord-017527-ylng1us2	170	7	infectious	infectious	JJ
cord-017527-ylng1us2	170	8	agents	agent	NNS
cord-017527-ylng1us2	170	9	,	,	,
cord-017527-ylng1us2	170	10	TSE	TSE	NNP
cord-017527-ylng1us2	170	11	agents	agent	NNS
cord-017527-ylng1us2	170	12	are	be	VBP
cord-017527-ylng1us2	170	13	resistant	resistant	JJ
cord-017527-ylng1us2	170	14	to	to	IN
cord-017527-ylng1us2	170	15	most	most	JJS
cord-017527-ylng1us2	170	16	of	of	IN
cord-017527-ylng1us2	170	17	the	the	DT
cord-017527-ylng1us2	170	18	physical	physical	JJ
cord-017527-ylng1us2	170	19	and	and	CC
cord-017527-ylng1us2	170	20	chemical	chemical	JJ
cord-017527-ylng1us2	170	21	methods	method	NNS
cord-017527-ylng1us2	170	22	commonly	commonly	RB
cord-017527-ylng1us2	170	23	used	use	VBN
cord-017527-ylng1us2	170	24	for	for	IN
cord-017527-ylng1us2	170	25	decontamination	decontamination	NN
cord-017527-ylng1us2	170	26	of	of	IN
cord-017527-ylng1us2	170	27	infectious	infectious	JJ
cord-017527-ylng1us2	170	28	agents	agent	NNS
cord-017527-ylng1us2	170	29	.	.	.
cord-017527-ylng1us2	171	1	It	-PRON-	PRP
cord-017527-ylng1us2	171	2	has	have	VBZ
cord-017527-ylng1us2	171	3	been	be	VBN
cord-017527-ylng1us2	171	4	shown	show	VBN
cord-017527-ylng1us2	171	5	that	that	IN
cord-017527-ylng1us2	171	6	neuroblastoma	neuroblastoma	NN
cord-017527-ylng1us2	171	7	cell	cell	NN
cord-017527-ylng1us2	171	8	lines	line	NNS
cord-017527-ylng1us2	171	9	,	,	,
cord-017527-ylng1us2	171	10	primary	primary	JJ
cord-017527-ylng1us2	171	11	cultured	cultured	JJ
cord-017527-ylng1us2	171	12	neurons	neuron	NNS
cord-017527-ylng1us2	171	13	and	and	CC
cord-017527-ylng1us2	171	14	astrocytes	astrocyte	NNS
cord-017527-ylng1us2	171	15	can	can	MD
cord-017527-ylng1us2	171	16	serve	serve	VB
cord-017527-ylng1us2	171	17	as	as	IN
cord-017527-ylng1us2	171	18	hosts	host	NNS
cord-017527-ylng1us2	171	19	(	(	-LRB-
cord-017527-ylng1us2	171	20	Butler	Butler	NNP
cord-017527-ylng1us2	171	21	et	et	NNP
cord-017527-ylng1us2	171	22	al	al	NNP
cord-017527-ylng1us2	171	23	.	.	.
cord-017527-ylng1us2	171	24	1988	1988	CD
cord-017527-ylng1us2	171	25	)	)	-RRB-
cord-017527-ylng1us2	171	26	.	.	.
cord-017527-ylng1us2	172	1	Although	although	IN
cord-017527-ylng1us2	172	2	many	many	JJ
cord-017527-ylng1us2	172	3	studies	study	NNS
cord-017527-ylng1us2	172	4	have	have	VBP
cord-017527-ylng1us2	172	5	suggested	suggest	VBN
cord-017527-ylng1us2	172	6	that	that	IN
cord-017527-ylng1us2	172	7	the	the	DT
cord-017527-ylng1us2	172	8	risk	risk	NN
cord-017527-ylng1us2	172	9	of	of	IN
cord-017527-ylng1us2	172	10	propagation	propagation	NN
cord-017527-ylng1us2	172	11	of	of	IN
cord-017527-ylng1us2	172	12	TSE	TSE	NNP
cord-017527-ylng1us2	172	13	agents	agent	NNS
cord-017527-ylng1us2	172	14	in	in	IN
cord-017527-ylng1us2	172	15	tissue	tissue	NN
cord-017527-ylng1us2	172	16	culture	culture	NN
cord-017527-ylng1us2	172	17	cells	cell	NNS
cord-017527-ylng1us2	172	18	cultivated	cultivate	VBN
cord-017527-ylng1us2	172	19	in	in	IN
cord-017527-ylng1us2	172	20	the	the	DT
cord-017527-ylng1us2	172	21	presence	presence	NN
cord-017527-ylng1us2	172	22	of	of	IN
cord-017527-ylng1us2	172	23	bovine	bovine	JJ
cord-017527-ylng1us2	172	24	serum	serum	NN
cord-017527-ylng1us2	172	25	potentially	potentially	RB
cord-017527-ylng1us2	172	26	contaminated	contaminate	VBN
cord-017527-ylng1us2	172	27	with	with	IN
cord-017527-ylng1us2	172	28	TSE	TSE	NNP
cord-017527-ylng1us2	172	29	was	be	VBD
cord-017527-ylng1us2	172	30	restricted	restrict	VBN
cord-017527-ylng1us2	172	31	to	to	IN
cord-017527-ylng1us2	172	32	neurons	neuron	NNS
cord-017527-ylng1us2	172	33	or	or	CC
cord-017527-ylng1us2	172	34	brain	brain	NN
cord-017527-ylng1us2	172	35	-	-	HYPH
cord-017527-ylng1us2	172	36	derived	derive	VBN
cord-017527-ylng1us2	172	37	cell	cell	NN
cord-017527-ylng1us2	172	38	cultures	culture	NNS
cord-017527-ylng1us2	172	39	,	,	,
cord-017527-ylng1us2	172	40	it	-PRON-	PRP
cord-017527-ylng1us2	172	41	has	have	VBZ
cord-017527-ylng1us2	172	42	been	be	VBN
cord-017527-ylng1us2	172	43	shown	show	VBN
cord-017527-ylng1us2	172	44	recently	recently	RB
cord-017527-ylng1us2	172	45	that	that	IN
cord-017527-ylng1us2	172	46	non	non	JJ
cord-017527-ylng1us2	172	47	-	-	JJ
cord-017527-ylng1us2	172	48	neuronal	neuronal	JJ
cord-017527-ylng1us2	172	49	cells	cell	NNS
cord-017527-ylng1us2	172	50	can	can	MD
cord-017527-ylng1us2	172	51	also	also	RB
cord-017527-ylng1us2	172	52	support	support	VB
cord-017527-ylng1us2	172	53	TSE	TSE	NNP
cord-017527-ylng1us2	172	54	infection	infection	NN
cord-017527-ylng1us2	172	55	,	,	,
cord-017527-ylng1us2	172	56	suggesting	suggest	VBG
cord-017527-ylng1us2	172	57	that	that	IN
cord-017527-ylng1us2	172	58	any	any	DT
cord-017527-ylng1us2	172	59	cell	cell	NN
cord-017527-ylng1us2	172	60	line	line	NN
cord-017527-ylng1us2	172	61	expressing	express	VBG
cord-017527-ylng1us2	172	62	normal	normal	JJ
cord-017527-ylng1us2	172	63	host	host	NN
cord-017527-ylng1us2	172	64	prion	prion	NN
cord-017527-ylng1us2	172	65	protein	protein	NN
cord-017527-ylng1us2	172	66	could	could	MD
cord-017527-ylng1us2	172	67	have	have	VB
cord-017527-ylng1us2	172	68	the	the	DT
cord-017527-ylng1us2	172	69	potential	potential	NN
cord-017527-ylng1us2	172	70	to	to	TO
cord-017527-ylng1us2	172	71	support	support	VB
cord-017527-ylng1us2	172	72	propagation	propagation	NN
cord-017527-ylng1us2	172	73	of	of	IN
cord-017527-ylng1us2	172	74	TSE	TSE	NNP
cord-017527-ylng1us2	172	75	agents	agent	NNS
cord-017527-ylng1us2	172	76	(	(	-LRB-
cord-017527-ylng1us2	172	77	Vilette	Vilette	NNP
cord-017527-ylng1us2	172	78	et	et	NNP
cord-017527-ylng1us2	172	79	al	al	NNP
cord-017527-ylng1us2	172	80	.	.	NNP
cord-017527-ylng1us2	172	81	2001	2001	CD
cord-017527-ylng1us2	172	82	;	;	:
cord-017527-ylng1us2	172	83	Vorberg	Vorberg	NNP
cord-017527-ylng1us2	172	84	et	et	NNP
cord-017527-ylng1us2	172	85	al	al	NNP
cord-017527-ylng1us2	172	86	.	.	.
cord-017527-ylng1us2	172	87	2004	2004	CD
cord-017527-ylng1us2	172	88	)	)	-RRB-
cord-017527-ylng1us2	172	89	.	.	.
cord-017527-ylng1us2	173	1	While	while	IN
cord-017527-ylng1us2	173	2	the	the	DT
cord-017527-ylng1us2	173	3	understanding	understanding	NN
cord-017527-ylng1us2	173	4	of	of	IN
cord-017527-ylng1us2	173	5	the	the	DT
cord-017527-ylng1us2	173	6	transmission	transmission	NN
cord-017527-ylng1us2	173	7	of	of	IN
cord-017527-ylng1us2	173	8	prions	prion	NNS
cord-017527-ylng1us2	173	9	is	be	VBZ
cord-017527-ylng1us2	173	10	still	still	RB
cord-017527-ylng1us2	173	11	in	in	IN
cord-017527-ylng1us2	173	12	progress	progress	NN
cord-017527-ylng1us2	173	13	(	(	-LRB-
cord-017527-ylng1us2	173	14	natural	natural	JJ
cord-017527-ylng1us2	173	15	transmission	transmission	NN
cord-017527-ylng1us2	173	16	seems	seem	VBZ
cord-017527-ylng1us2	173	17	mainly	mainly	RB
cord-017527-ylng1us2	173	18	to	to	TO
cord-017527-ylng1us2	173	19	take	take	VB
cord-017527-ylng1us2	173	20	place	place	NN
cord-017527-ylng1us2	173	21	via	via	IN
cord-017527-ylng1us2	173	22	oral	oral	JJ
cord-017527-ylng1us2	173	23	route	route	NN
cord-017527-ylng1us2	173	24	in	in	IN
cord-017527-ylng1us2	173	25	human	human	NN
cord-017527-ylng1us2	173	26	and	and	CC
cord-017527-ylng1us2	173	27	animals	animal	NNS
cord-017527-ylng1us2	173	28	)	)	-RRB-
cord-017527-ylng1us2	173	29	,	,	,
cord-017527-ylng1us2	173	30	investigators	investigator	NNS
cord-017527-ylng1us2	173	31	using	use	VBG
cord-017527-ylng1us2	173	32	cell	cell	NN
cord-017527-ylng1us2	173	33	cultures	culture	NNS
cord-017527-ylng1us2	173	34	need	need	VBP
cord-017527-ylng1us2	173	35	to	to	TO
cord-017527-ylng1us2	173	36	take	take	VB
cord-017527-ylng1us2	173	37	into	into	IN
cord-017527-ylng1us2	173	38	account	account	NN
cord-017527-ylng1us2	173	39	different	different	JJ
cord-017527-ylng1us2	173	40	routes	route	NNS
cord-017527-ylng1us2	173	41	by	by	IN
cord-017527-ylng1us2	173	42	which	which	WDT
cord-017527-ylng1us2	173	43	these	these	DT
cord-017527-ylng1us2	173	44	agents	agent	NNS
cord-017527-ylng1us2	173	45	may	may	MD
cord-017527-ylng1us2	173	46	be	be	VB
cord-017527-ylng1us2	173	47	transmitted	transmit	VBN
cord-017527-ylng1us2	173	48	experimentally	experimentally	RB
cord-017527-ylng1us2	173	49	.	.	.
cord-017527-ylng1us2	174	1	Mouse	mouse	NN
cord-017527-ylng1us2	174	2	scrapie	scrapie	NN
cord-017527-ylng1us2	174	3	aerosol	aerosol	NN
cord-017527-ylng1us2	174	4	transmission	transmission	NN
cord-017527-ylng1us2	174	5	has	have	VBZ
cord-017527-ylng1us2	174	6	been	be	VBN
cord-017527-ylng1us2	174	7	successfully	successfully	RB
cord-017527-ylng1us2	174	8	obtained	obtain	VBN
cord-017527-ylng1us2	174	9	in	in	IN
cord-017527-ylng1us2	174	10	mice	mouse	NNS
cord-017527-ylng1us2	174	11	Haybaeck	Haybaeck	NNP
cord-017527-ylng1us2	174	12	et	et	NNP
cord-017527-ylng1us2	174	13	al	al	NNP
cord-017527-ylng1us2	174	14	.	.	NNP
cord-017527-ylng1us2	174	15	2011	2011	CD
cord-017527-ylng1us2	174	16	)	)	-RRB-
cord-017527-ylng1us2	174	17	.	.	.
cord-017527-ylng1us2	175	1	In	in	IN
cord-017527-ylng1us2	175	2	cervids	cervid	NNS
cord-017527-ylng1us2	175	3	,	,	,
cord-017527-ylng1us2	175	4	Chronic	Chronic	NNP
cord-017527-ylng1us2	175	5	Wasting	waste	VBG
cord-017527-ylng1us2	175	6	Disease	Disease	NNP
cord-017527-ylng1us2	175	7	(	(	-LRB-
cord-017527-ylng1us2	175	8	CWD	CWD	NNP
cord-017527-ylng1us2	175	9	)	)	-RRB-
cord-017527-ylng1us2	175	10	was	be	VBD
cord-017527-ylng1us2	175	11	already	already	RB
cord-017527-ylng1us2	175	12	proposed	propose	VBN
cord-017527-ylng1us2	175	13	as	as	IN
cord-017527-ylng1us2	175	14	a	a	DT
cord-017527-ylng1us2	175	15	natural	natural	JJ
cord-017527-ylng1us2	175	16	airborne	airborne	JJ
cord-017527-ylng1us2	175	17	pathogen	pathogen	NN
cord-017527-ylng1us2	175	18	(	(	-LRB-
cord-017527-ylng1us2	175	19	Denkers	Denkers	NNP
cord-017527-ylng1us2	175	20	et	et	NNP
cord-017527-ylng1us2	175	21	al	al	NNP
cord-017527-ylng1us2	175	22	.	.	NNP
cord-017527-ylng1us2	175	23	2010	2010	CD
cord-017527-ylng1us2	175	24	)	)	-RRB-
cord-017527-ylng1us2	175	25	.	.	.
cord-017527-ylng1us2	176	1	In	in	IN
cord-017527-ylng1us2	176	2	the	the	DT
cord-017527-ylng1us2	176	3	case	case	NN
cord-017527-ylng1us2	176	4	of	of	IN
cord-017527-ylng1us2	176	5	Creutzfeldt	Creutzfeldt	NNP
cord-017527-ylng1us2	176	6	Jacob	Jacob	NNP
cord-017527-ylng1us2	176	7	Disease	Disease	NNP
cord-017527-ylng1us2	176	8	(	(	-LRB-
cord-017527-ylng1us2	176	9	CJD	CJD	NNP
cord-017527-ylng1us2	176	10	)	)	-RRB-
cord-017527-ylng1us2	176	11	,	,	,
cord-017527-ylng1us2	176	12	there	there	EX
cord-017527-ylng1us2	176	13	is	be	VBZ
cord-017527-ylng1us2	176	14	to	to	IN
cord-017527-ylng1us2	176	15	date	date	VB
cord-017527-ylng1us2	176	16	no	no	DT
cord-017527-ylng1us2	176	17	proof	proof	NN
cord-017527-ylng1us2	176	18	of	of	IN
cord-017527-ylng1us2	176	19	release	release	NN
cord-017527-ylng1us2	176	20	of	of	IN
cord-017527-ylng1us2	176	21	prion	prion	NN
cord-017527-ylng1us2	176	22	into	into	IN
cord-017527-ylng1us2	176	23	aerosols	aerosol	NNS
cord-017527-ylng1us2	176	24	.	.	.
cord-017527-ylng1us2	177	1	Animal	animal	NN
cord-017527-ylng1us2	177	2	cell	cell	NN
cord-017527-ylng1us2	177	3	cultures	culture	NNS
cord-017527-ylng1us2	177	4	can	can	MD
cord-017527-ylng1us2	177	5	also	also	RB
cord-017527-ylng1us2	177	6	harbour	harbour	VB
cord-017527-ylng1us2	177	7	unknown	unknown	JJ
cord-017527-ylng1us2	177	8	pathogens	pathogen	NNS
cord-017527-ylng1us2	177	9	or	or	CC
cord-017527-ylng1us2	177	10	whose	whose	WP$
cord-017527-ylng1us2	177	11	tropism	tropism	NN
cord-017527-ylng1us2	177	12	has	have	VBZ
cord-017527-ylng1us2	177	13	not	not	RB
cord-017527-ylng1us2	177	14	been	be	VBN
cord-017527-ylng1us2	177	15	defined	define	VBN
cord-017527-ylng1us2	177	16	yet	yet	RB
cord-017527-ylng1us2	177	17	.	.	.
cord-017527-ylng1us2	178	1	Examples	example	NNS
cord-017527-ylng1us2	178	2	described	describe	VBN
cord-017527-ylng1us2	178	3	in	in	IN
cord-017527-ylng1us2	178	4	the	the	DT
cord-017527-ylng1us2	178	5	literature	literature	NN
cord-017527-ylng1us2	178	6	include	include	VBP
cord-017527-ylng1us2	178	7	viruses	virus	NNS
cord-017527-ylng1us2	178	8	such	such	JJ
cord-017527-ylng1us2	178	9	as	as	IN
cord-017527-ylng1us2	178	10	Hepatitis	Hepatitis	NNP
cord-017527-ylng1us2	178	11	G	G	NNP
cord-017527-ylng1us2	178	12	(	(	-LRB-
cord-017527-ylng1us2	178	13	Linnen	Linnen	NNP
cord-017527-ylng1us2	178	14	et	et	FW
cord-017527-ylng1us2	178	15	al	al	NNP
cord-017527-ylng1us2	178	16	.	.	.
cord-017527-ylng1us2	178	17	1996	1996	CD
cord-017527-ylng1us2	178	18	)	)	-RRB-
cord-017527-ylng1us2	178	19	,	,	,
cord-017527-ylng1us2	178	20	HHV8	HHV8	NNP
cord-017527-ylng1us2	178	21	(	(	-LRB-
cord-017527-ylng1us2	178	22	Moore	Moore	NNP
cord-017527-ylng1us2	178	23	et	et	NNP
cord-017527-ylng1us2	178	24	al	al	NNP
cord-017527-ylng1us2	178	25	.	.	.
cord-017527-ylng1us2	178	26	1996	1996	CD
cord-017527-ylng1us2	178	27	)	)	-RRB-
cord-017527-ylng1us2	178	28	,	,	,
cord-017527-ylng1us2	178	29	TT	TT	NNP
cord-017527-ylng1us2	178	30	virus	virus	NN
cord-017527-ylng1us2	178	31	(	(	-LRB-
cord-017527-ylng1us2	178	32	Nishizawa	Nishizawa	NNP
cord-017527-ylng1us2	178	33	et	et	NNP
cord-017527-ylng1us2	178	34	al	al	NNP
cord-017527-ylng1us2	178	35	.	.	.
cord-017527-ylng1us2	178	36	1997	1997	CD
cord-017527-ylng1us2	178	37	)	)	-RRB-
cord-017527-ylng1us2	178	38	or	or	CC
cord-017527-ylng1us2	178	39	human	human	JJ
cord-017527-ylng1us2	178	40	pneumovirus	pneumovirus	NNP
cord-017527-ylng1us2	178	41	(	(	-LRB-
cord-017527-ylng1us2	178	42	van	van	NNP
cord-017527-ylng1us2	178	43	den	den	NNP
cord-017527-ylng1us2	178	44	Hoogen	Hoogen	NNP
cord-017527-ylng1us2	178	45	et	et	NNP
cord-017527-ylng1us2	178	46	al	al	NNP
cord-017527-ylng1us2	178	47	.	.	NNP
cord-017527-ylng1us2	178	48	2001	2001	CD
cord-017527-ylng1us2	178	49	)	)	-RRB-
cord-017527-ylng1us2	178	50	.	.	.
cord-017527-ylng1us2	179	1	Cell	cell	NN
cord-017527-ylng1us2	179	2	cultures	culture	NNS
cord-017527-ylng1us2	179	3	can	can	MD
cord-017527-ylng1us2	179	4	be	be	VB
cord-017527-ylng1us2	179	5	contaminated	contaminate	VBN
cord-017527-ylng1us2	179	6	by	by	IN
cord-017527-ylng1us2	179	7	different	different	JJ
cord-017527-ylng1us2	179	8	sources	source	NNS
cord-017527-ylng1us2	179	9	.	.	.
cord-017527-ylng1us2	180	1	Infected	infected	JJ
cord-017527-ylng1us2	180	2	organisms	organism	NNS
cord-017527-ylng1us2	180	3	or	or	CC
cord-017527-ylng1us2	180	4	infected	infect	VBN
cord-017527-ylng1us2	180	5	animal	animal	NN
cord-017527-ylng1us2	180	6	cells	cell	NNS
cord-017527-ylng1us2	180	7	or	or	CC
cord-017527-ylng1us2	180	8	tissues	tissue	NNS
cord-017527-ylng1us2	180	9	from	from	IN
cord-017527-ylng1us2	180	10	which	which	WDT
cord-017527-ylng1us2	180	11	a	a	DT
cord-017527-ylng1us2	180	12	cell	cell	NN
cord-017527-ylng1us2	180	13	line	line	NN
cord-017527-ylng1us2	180	14	has	have	VBZ
cord-017527-ylng1us2	180	15	been	be	VBN
cord-017527-ylng1us2	180	16	established	establish	VBN
cord-017527-ylng1us2	180	17	are	be	VBP
cord-017527-ylng1us2	180	18	the	the	DT
cord-017527-ylng1us2	180	19	primary	primary	JJ
cord-017527-ylng1us2	180	20	source	source	NN
cord-017527-ylng1us2	180	21	of	of	IN
cord-017527-ylng1us2	180	22	contamination	contamination	NN
cord-017527-ylng1us2	180	23	.	.	.
cord-017527-ylng1us2	181	1	An	an	DT
cord-017527-ylng1us2	181	2	accidental	accidental	JJ
cord-017527-ylng1us2	181	3	contamination	contamination	NN
cord-017527-ylng1us2	181	4	can	can	MD
cord-017527-ylng1us2	181	5	also	also	RB
cord-017527-ylng1us2	181	6	occur	occur	VB
cord-017527-ylng1us2	181	7	through	through	IN
cord-017527-ylng1us2	181	8	the	the	DT
cord-017527-ylng1us2	181	9	material	material	NN
cord-017527-ylng1us2	181	10	used	use	VBN
cord-017527-ylng1us2	181	11	for	for	IN
cord-017527-ylng1us2	181	12	cell	cell	NN
cord-017527-ylng1us2	181	13	culturing	culture	VBG
cord-017527-ylng1us2	181	14	including	include	VBG
cord-017527-ylng1us2	181	15	glassware	glassware	NN
cord-017527-ylng1us2	181	16	,	,	,
cord-017527-ylng1us2	181	17	storage	storage	NN
cord-017527-ylng1us2	181	18	bottles	bottle	NNS
cord-017527-ylng1us2	181	19	and	and	CC
cord-017527-ylng1us2	181	20	pipettes	pipette	NNS
cord-017527-ylng1us2	181	21	due	due	JJ
cord-017527-ylng1us2	181	22	to	to	IN
cord-017527-ylng1us2	181	23	incorrect	incorrect	JJ
cord-017527-ylng1us2	181	24	maintenance	maintenance	NN
cord-017527-ylng1us2	181	25	or	or	CC
cord-017527-ylng1us2	181	26	sterilisation	sterilisation	NN
cord-017527-ylng1us2	181	27	.	.	.
cord-017527-ylng1us2	182	1	Before	before	IN
cord-017527-ylng1us2	182	2	the	the	DT
cord-017527-ylng1us2	182	3	use	use	NN
cord-017527-ylng1us2	182	4	of	of	IN
cord-017527-ylng1us2	182	5	disposable	disposable	JJ
cord-017527-ylng1us2	182	6	material	material	NN
cord-017527-ylng1us2	182	7	the	the	DT
cord-017527-ylng1us2	182	8	lip	lip	NN
cord-017527-ylng1us2	182	9	of	of	IN
cord-017527-ylng1us2	182	10	the	the	DT
cord-017527-ylng1us2	182	11	culture	culture	NN
cord-017527-ylng1us2	182	12	flask	flask	NN
cord-017527-ylng1us2	182	13	and	and	CC
cord-017527-ylng1us2	182	14	the	the	DT
cord-017527-ylng1us2	182	15	outside	outside	NN
cord-017527-ylng1us2	182	16	of	of	IN
cord-017527-ylng1us2	182	17	the	the	DT
cord-017527-ylng1us2	182	18	used	use	VBN
cord-017527-ylng1us2	182	19	pipette	pipette	NN
cord-017527-ylng1us2	182	20	were	be	VBD
cord-017527-ylng1us2	182	21	important	important	JJ
cord-017527-ylng1us2	182	22	sources	source	NNS
cord-017527-ylng1us2	182	23	of	of	IN
cord-017527-ylng1us2	182	24	contamination	contamination	NN
cord-017527-ylng1us2	182	25	with	with	IN
cord-017527-ylng1us2	182	26	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	182	27	(	(	-LRB-
cord-017527-ylng1us2	182	28	McGarrity	McGarrity	NNP
cord-017527-ylng1us2	182	29	1976	1976	CD
cord-017527-ylng1us2	182	30	)	)	-RRB-
cord-017527-ylng1us2	182	31	.	.	.
cord-017527-ylng1us2	183	1	Nowadays	nowadays	RB
cord-017527-ylng1us2	183	2	,	,	,
cord-017527-ylng1us2	183	3	the	the	DT
cord-017527-ylng1us2	183	4	use	use	NN
cord-017527-ylng1us2	183	5	of	of	IN
cord-017527-ylng1us2	183	6	disposable	disposable	JJ
cord-017527-ylng1us2	183	7	and	and	CC
cord-017527-ylng1us2	183	8	sterile	sterile	JJ
cord-017527-ylng1us2	183	9	pipettes	pipette	NNS
cord-017527-ylng1us2	183	10	has	have	VBZ
cord-017527-ylng1us2	183	11	significantly	significantly	RB
cord-017527-ylng1us2	183	12	decreased	decrease	VBN
cord-017527-ylng1us2	183	13	the	the	DT
cord-017527-ylng1us2	183	14	likelihood	likelihood	NN
cord-017527-ylng1us2	183	15	of	of	IN
cord-017527-ylng1us2	183	16	adventitious	adventitious	JJ
cord-017527-ylng1us2	183	17	contamination	contamination	NN
cord-017527-ylng1us2	183	18	.	.	.
cord-017527-ylng1us2	184	1	A	a	DT
cord-017527-ylng1us2	184	2	third	third	JJ
cord-017527-ylng1us2	184	3	source	source	NN
cord-017527-ylng1us2	184	4	of	of	IN
cord-017527-ylng1us2	184	5	contamination	contamination	NN
cord-017527-ylng1us2	184	6	resides	reside	VBZ
cord-017527-ylng1us2	184	7	in	in	IN
cord-017527-ylng1us2	184	8	culture	culture	NN
cord-017527-ylng1us2	184	9	media	medium	NNS
cord-017527-ylng1us2	184	10	and	and	CC
cord-017527-ylng1us2	184	11	its	-PRON-	PRP$
cord-017527-ylng1us2	184	12	components	component	NNS
cord-017527-ylng1us2	184	13	such	such	JJ
cord-017527-ylng1us2	184	14	as	as	IN
cord-017527-ylng1us2	184	15	serum	serum	NN
cord-017527-ylng1us2	184	16	,	,	,
cord-017527-ylng1us2	184	17	basic	basic	JJ
cord-017527-ylng1us2	184	18	culture	culture	NN
cord-017527-ylng1us2	184	19	media	medium	NNS
cord-017527-ylng1us2	184	20	and	and	CC
cord-017527-ylng1us2	184	21	salt	salt	NN
cord-017527-ylng1us2	184	22	solutions	solution	NNS
cord-017527-ylng1us2	184	23	and	and	CC
cord-017527-ylng1us2	184	24	enzymes	enzyme	NNS
cord-017527-ylng1us2	184	25	(	(	-LRB-
cord-017527-ylng1us2	184	26	trypsin	trypsin	NN
cord-017527-ylng1us2	184	27	,	,	,
cord-017527-ylng1us2	184	28	pronase	pronase	NNP
cord-017527-ylng1us2	184	29	and	and	CC
cord-017527-ylng1us2	184	30	collagenase	collagenase	NNP
cord-017527-ylng1us2	184	31	)	)	-RRB-
cord-017527-ylng1us2	184	32	.	.	.
cord-017527-ylng1us2	185	1	For	for	IN
cord-017527-ylng1us2	185	2	example	example	NN
cord-017527-ylng1us2	185	3	,	,	,
cord-017527-ylng1us2	185	4	media	medium	NNS
cord-017527-ylng1us2	185	5	and	and	CC
cord-017527-ylng1us2	185	6	additives	additive	NNS
cord-017527-ylng1us2	185	7	derived	derive	VBN
cord-017527-ylng1us2	185	8	from	from	IN
cord-017527-ylng1us2	185	9	bovine	bovine	JJ
cord-017527-ylng1us2	185	10	sources	source	NNS
cord-017527-ylng1us2	185	11	are	be	VBP
cord-017527-ylng1us2	185	12	often	often	RB
cord-017527-ylng1us2	185	13	contaminated	contaminate	VBN
cord-017527-ylng1us2	185	14	with	with	IN
cord-017527-ylng1us2	185	15	bovine	bovine	JJ
cord-017527-ylng1us2	185	16	viral	viral	JJ
cord-017527-ylng1us2	185	17	diarrhoea	diarrhoea	NN
cord-017527-ylng1us2	185	18	virus	virus	NN
cord-017527-ylng1us2	185	19	(	(	-LRB-
cord-017527-ylng1us2	185	20	BVDV	BVDV	NNP
cord-017527-ylng1us2	185	21	)	)	-RRB-
cord-017527-ylng1us2	186	1	(	(	-LRB-
cord-017527-ylng1us2	186	2	Levings	Levings	NNP
cord-017527-ylng1us2	186	3	and	and	CC
cord-017527-ylng1us2	186	4	Wessman	Wessman	NNP
cord-017527-ylng1us2	186	5	1991	1991	CD
cord-017527-ylng1us2	186	6	)	)	-RRB-
cord-017527-ylng1us2	186	7	.	.	.
cord-017527-ylng1us2	187	1	As	as	IN
cord-017527-ylng1us2	187	2	mentioned	mention	VBN
cord-017527-ylng1us2	187	3	above	above	IN
cord-017527-ylng1us2	187	4	the	the	DT
cord-017527-ylng1us2	187	5	relative	relative	JJ
cord-017527-ylng1us2	187	6	resistance	resistance	NN
cord-017527-ylng1us2	187	7	of	of	IN
cord-017527-ylng1us2	187	8	TSE	TSE	NNP
cord-017527-ylng1us2	187	9	agents	agent	NNS
cord-017527-ylng1us2	187	10	may	may	MD
cord-017527-ylng1us2	187	11	also	also	RB
cord-017527-ylng1us2	187	12	be	be	VB
cord-017527-ylng1us2	187	13	an	an	DT
cord-017527-ylng1us2	187	14	issue	issue	NN
cord-017527-ylng1us2	187	15	when	when	WRB
cord-017527-ylng1us2	187	16	using	use	VBG
cord-017527-ylng1us2	187	17	bovinederived	bovinederive	VBN
cord-017527-ylng1us2	187	18	products	product	NNS
cord-017527-ylng1us2	187	19	as	as	IN
cord-017527-ylng1us2	187	20	tissue	tissue	NN
cord-017527-ylng1us2	187	21	culture	culture	NN
cord-017527-ylng1us2	187	22	supplements	supplement	NNS
cord-017527-ylng1us2	187	23	.	.	.
cord-017527-ylng1us2	188	1	Finally	finally	RB
cord-017527-ylng1us2	188	2	,	,	,
cord-017527-ylng1us2	188	3	non	non	JJ
cord-017527-ylng1us2	188	4	-	-	JJ
cord-017527-ylng1us2	188	5	filtered	filtered	JJ
cord-017527-ylng1us2	188	6	air	air	NN
cord-017527-ylng1us2	188	7	supply	supply	NN
cord-017527-ylng1us2	188	8	,	,	,
cord-017527-ylng1us2	188	9	clothing	clothing	NN
cord-017527-ylng1us2	188	10	,	,	,
cord-017527-ylng1us2	188	11	personnel	personnel	NNS
cord-017527-ylng1us2	188	12	and	and	CC
cord-017527-ylng1us2	188	13	floor	floor	NN
cord-017527-ylng1us2	188	14	can	can	MD
cord-017527-ylng1us2	188	15	be	be	VB
cord-017527-ylng1us2	188	16	a	a	DT
cord-017527-ylng1us2	188	17	source	source	NN
cord-017527-ylng1us2	188	18	of	of	IN
cord-017527-ylng1us2	188	19	airborne	airborne	JJ
cord-017527-ylng1us2	188	20	contamination	contamination	NN
cord-017527-ylng1us2	188	21	(	(	-LRB-
cord-017527-ylng1us2	188	22	Hay	Hay	NNP
cord-017527-ylng1us2	188	23	1991	1991	CD
cord-017527-ylng1us2	188	24	)	)	-RRB-
cord-017527-ylng1us2	188	25	.	.	.
cord-017527-ylng1us2	189	1	Genetically	genetically	RB
cord-017527-ylng1us2	189	2	modified	modify	VBN
cord-017527-ylng1us2	189	3	(	(	-LRB-
cord-017527-ylng1us2	189	4	GM	GM	NNP
cord-017527-ylng1us2	189	5	)	)	-RRB-
cord-017527-ylng1us2	189	6	animal	animal	NN
cord-017527-ylng1us2	189	7	cell	cell	NN
cord-017527-ylng1us2	189	8	cultures	culture	NNS
cord-017527-ylng1us2	189	9	are	be	VBP
cord-017527-ylng1us2	189	10	employed	employ	VBN
cord-017527-ylng1us2	189	11	for	for	IN
cord-017527-ylng1us2	189	12	a	a	DT
cord-017527-ylng1us2	189	13	number	number	NN
cord-017527-ylng1us2	189	14	of	of	IN
cord-017527-ylng1us2	189	15	different	different	JJ
cord-017527-ylng1us2	189	16	activities	activity	NNS
cord-017527-ylng1us2	189	17	.	.	.
cord-017527-ylng1us2	190	1	For	for	IN
cord-017527-ylng1us2	190	2	example	example	NN
cord-017527-ylng1us2	190	3	,	,	,
cord-017527-ylng1us2	190	4	the	the	DT
cord-017527-ylng1us2	190	5	expression	expression	NN
cord-017527-ylng1us2	190	6	of	of	IN
cord-017527-ylng1us2	190	7	transgenes	transgene	NNS
cord-017527-ylng1us2	190	8	and	and	CC
cord-017527-ylng1us2	190	9	production	production	NN
cord-017527-ylng1us2	190	10	of	of	IN
cord-017527-ylng1us2	190	11	proteins	protein	NNS
cord-017527-ylng1us2	190	12	of	of	IN
cord-017527-ylng1us2	190	13	interest	interest	NN
cord-017527-ylng1us2	190	14	whose	whose	WP$
cord-017527-ylng1us2	190	15	function	function	NN
cord-017527-ylng1us2	190	16	depends	depend	VBZ
cord-017527-ylng1us2	190	17	on	on	IN
cord-017527-ylng1us2	190	18	methylation	methylation	NN
cord-017527-ylng1us2	190	19	,	,	,
cord-017527-ylng1us2	190	20	sulfation	sulfation	NN
cord-017527-ylng1us2	190	21	,	,	,
cord-017527-ylng1us2	190	22	phosphorylation	phosphorylation	NN
cord-017527-ylng1us2	190	23	,	,	,
cord-017527-ylng1us2	190	24	lipid	lipid	NN
cord-017527-ylng1us2	190	25	addition	addition	NN
cord-017527-ylng1us2	190	26	,	,	,
cord-017527-ylng1us2	190	27	or	or	CC
cord-017527-ylng1us2	190	28	glycosylation	glycosylation	NN
cord-017527-ylng1us2	190	29	may	may	MD
cord-017527-ylng1us2	190	30	necessitate	necessitate	VB
cord-017527-ylng1us2	190	31	the	the	DT
cord-017527-ylng1us2	190	32	capacity	capacity	NN
cord-017527-ylng1us2	190	33	of	of	IN
cord-017527-ylng1us2	190	34	higher	high	JJR
cord-017527-ylng1us2	190	35	eukaryotic	eukaryotic	JJ
cord-017527-ylng1us2	190	36	cells	cell	NNS
cord-017527-ylng1us2	190	37	to	to	TO
cord-017527-ylng1us2	190	38	perform	perform	VB
cord-017527-ylng1us2	190	39	post	post	JJ
cord-017527-ylng1us2	190	40	-	-	JJ
cord-017527-ylng1us2	190	41	translational	translational	JJ
cord-017527-ylng1us2	190	42	modifications	modification	NNS
cord-017527-ylng1us2	190	43	.	.	.
cord-017527-ylng1us2	191	1	GM	GM	NNP
cord-017527-ylng1us2	191	2	animal	animal	NN
cord-017527-ylng1us2	191	3	cell	cell	NN
cord-017527-ylng1us2	191	4	cultures	culture	NNS
cord-017527-ylng1us2	191	5	may	may	MD
cord-017527-ylng1us2	191	6	also	also	RB
cord-017527-ylng1us2	191	7	be	be	VB
cord-017527-ylng1us2	191	8	chosen	choose	VBN
cord-017527-ylng1us2	191	9	for	for	IN
cord-017527-ylng1us2	191	10	the	the	DT
cord-017527-ylng1us2	191	11	replication	replication	NN
cord-017527-ylng1us2	191	12	of	of	IN
cord-017527-ylng1us2	191	13	defective	defective	JJ
cord-017527-ylng1us2	191	14	recombinant	recombinant	JJ
cord-017527-ylng1us2	191	15	or	or	CC
cord-017527-ylng1us2	191	16	even	even	RB
cord-017527-ylng1us2	191	17	wild	wild	JJ
cord-017527-ylng1us2	191	18	type	type	NN
cord-017527-ylng1us2	191	19	viruses	virus	NNS
cord-017527-ylng1us2	191	20	.	.	.
cord-017527-ylng1us2	192	1	The	the	DT
cord-017527-ylng1us2	192	2	risk	risk	NN
cord-017527-ylng1us2	192	3	assessment	assessment	NN
cord-017527-ylng1us2	192	4	of	of	IN
cord-017527-ylng1us2	192	5	GM	GM	NNP
cord-017527-ylng1us2	192	6	cells	cell	NNS
cord-017527-ylng1us2	192	7	should	should	MD
cord-017527-ylng1us2	192	8	follow	follow	VB
cord-017527-ylng1us2	192	9	the	the	DT
cord-017527-ylng1us2	192	10	five	five	CD
cord-017527-ylng1us2	192	11	-	-	HYPH
cord-017527-ylng1us2	192	12	step	step	NN
cord-017527-ylng1us2	192	13	methodology	methodology	NN
cord-017527-ylng1us2	192	14	as	as	IN
cord-017527-ylng1us2	192	15	outlined	outline	VBN
cord-017527-ylng1us2	192	16	in	in	IN
cord-017527-ylng1us2	192	17	Fig	Fig	NNP
cord-017527-ylng1us2	192	18	.	.	.
cord-017527-ylng1us2	193	1	22	22	CD
cord-017527-ylng1us2	193	2	.1	.1	NNS
cord-017527-ylng1us2	193	3	,	,	,
cord-017527-ylng1us2	193	4	which	which	WDT
cord-017527-ylng1us2	193	5	means	mean	VBZ
cord-017527-ylng1us2	193	6	that	that	IN
cord-017527-ylng1us2	193	7	an	an	DT
cord-017527-ylng1us2	193	8	evaluation	evaluation	NN
cord-017527-ylng1us2	193	9	of	of	IN
cord-017527-ylng1us2	193	10	each	each	DT
cord-017527-ylng1us2	193	11	individual	individual	JJ
cord-017527-ylng1us2	193	12	aspect	aspect	NN
cord-017527-ylng1us2	193	13	in	in	IN
cord-017527-ylng1us2	193	14	the	the	DT
cord-017527-ylng1us2	193	15	process	process	NN
cord-017527-ylng1us2	193	16	of	of	IN
cord-017527-ylng1us2	193	17	genetic	genetic	JJ
cord-017527-ylng1us2	193	18	modification	modification	NN
cord-017527-ylng1us2	193	19	should	should	MD
cord-017527-ylng1us2	193	20	be	be	VB
cord-017527-ylng1us2	193	21	performed	perform	VBN
cord-017527-ylng1us2	193	22	.	.	.
cord-017527-ylng1us2	194	1	This	this	DT
cord-017527-ylng1us2	194	2	includes	include	VBZ
cord-017527-ylng1us2	194	3	an	an	DT
cord-017527-ylng1us2	194	4	evaluation	evaluation	NN
cord-017527-ylng1us2	194	5	of	of	IN
cord-017527-ylng1us2	194	6	the	the	DT
cord-017527-ylng1us2	194	7	recipient	recipient	NN
cord-017527-ylng1us2	194	8	cell	cell	NN
cord-017527-ylng1us2	194	9	,	,	,
cord-017527-ylng1us2	194	10	the	the	DT
cord-017527-ylng1us2	194	11	vector	vector	NN
cord-017527-ylng1us2	194	12	,	,	,
cord-017527-ylng1us2	194	13	the	the	DT
cord-017527-ylng1us2	194	14	donor	donor	NN
cord-017527-ylng1us2	194	15	organism	organism	NN
cord-017527-ylng1us2	194	16	properties	property	NNS
cord-017527-ylng1us2	194	17	and	and	CC
cord-017527-ylng1us2	194	18	an	an	DT
cord-017527-ylng1us2	194	19	assessment	assessment	NN
cord-017527-ylng1us2	194	20	of	of	IN
cord-017527-ylng1us2	194	21	the	the	DT
cord-017527-ylng1us2	194	22	characteristics	characteristic	NNS
cord-017527-ylng1us2	194	23	of	of	IN
cord-017527-ylng1us2	194	24	the	the	DT
cord-017527-ylng1us2	194	25	inserted	insert	VBN
cord-017527-ylng1us2	194	26	genetic	genetic	JJ
cord-017527-ylng1us2	194	27	material	material	NN
cord-017527-ylng1us2	194	28	.	.	.
cord-017527-ylng1us2	195	1	A	a	DT
cord-017527-ylng1us2	195	2	comprehensive	comprehensive	JJ
cord-017527-ylng1us2	195	3	risk	risk	NN
cord-017527-ylng1us2	195	4	assessment	assessment	NN
cord-017527-ylng1us2	195	5	of	of	IN
cord-017527-ylng1us2	195	6	genetically	genetically	RB
cord-017527-ylng1us2	195	7	modified	modify	VBN
cord-017527-ylng1us2	195	8	cells	cell	NNS
cord-017527-ylng1us2	195	9	expressing	express	VBG
cord-017527-ylng1us2	195	10	transgenes	transgene	NNS
cord-017527-ylng1us2	195	11	should	should	MD
cord-017527-ylng1us2	195	12	also	also	RB
cord-017527-ylng1us2	195	13	take	take	VB
cord-017527-ylng1us2	195	14	into	into	IN
cord-017527-ylng1us2	195	15	account	account	NN
cord-017527-ylng1us2	195	16	the	the	DT
cord-017527-ylng1us2	195	17	risk	risk	NN
cord-017527-ylng1us2	195	18	associated	associate	VBN
cord-017527-ylng1us2	195	19	with	with	IN
cord-017527-ylng1us2	195	20	the	the	DT
cord-017527-ylng1us2	195	21	transgene	transgene	NN
cord-017527-ylng1us2	195	22	products	product	NNS
cord-017527-ylng1us2	195	23	.	.	.
cord-017527-ylng1us2	196	1	A	a	DT
cord-017527-ylng1us2	196	2	gene	gene	NN
cord-017527-ylng1us2	196	3	product	product	NN
cord-017527-ylng1us2	196	4	may	may	MD
cord-017527-ylng1us2	196	5	be	be	VB
cord-017527-ylng1us2	196	6	intrinsically	intrinsically	RB
cord-017527-ylng1us2	196	7	harmful	harmful	JJ
cord-017527-ylng1us2	196	8	(	(	-LRB-
cord-017527-ylng1us2	196	9	e.g.	e.g.	JJ
cord-017527-ylng1us2	196	10	toxic	toxic	JJ
cord-017527-ylng1us2	196	11	properties	property	NNS
cord-017527-ylng1us2	196	12	)	)	-RRB-
cord-017527-ylng1us2	196	13	or	or	CC
cord-017527-ylng1us2	196	14	could	could	MD
cord-017527-ylng1us2	196	15	induce	induce	VB
cord-017527-ylng1us2	196	16	hazardous	hazardous	JJ
cord-017527-ylng1us2	196	17	properties	property	NNS
cord-017527-ylng1us2	196	18	via	via	IN
cord-017527-ylng1us2	196	19	its	-PRON-	PRP$
cord-017527-ylng1us2	196	20	expression	expression	NN
cord-017527-ylng1us2	196	21	in	in	IN
cord-017527-ylng1us2	196	22	GM	GM	NNP
cord-017527-ylng1us2	196	23	cells	cell	NNS
cord-017527-ylng1us2	196	24	,	,	,
cord-017527-ylng1us2	196	25	dependent	dependent	JJ
cord-017527-ylng1us2	196	26	upon	upon	IN
cord-017527-ylng1us2	196	27	the	the	DT
cord-017527-ylng1us2	196	28	genome	genome	NN
cord-017527-ylng1us2	196	29	integration	integration	NN
cord-017527-ylng1us2	196	30	site	site	NN
cord-017527-ylng1us2	196	31	,	,	,
cord-017527-ylng1us2	196	32	promoter	promoter	NN
cord-017527-ylng1us2	196	33	activity	activity	NN
cord-017527-ylng1us2	196	34	and	and	CC
cord-017527-ylng1us2	196	35	expression	expression	NN
cord-017527-ylng1us2	196	36	of	of	IN
cord-017527-ylng1us2	196	37	regulatory	regulatory	JJ
cord-017527-ylng1us2	196	38	sequences	sequence	NNS
cord-017527-ylng1us2	196	39	governing	govern	VBG
cord-017527-ylng1us2	196	40	expression	expression	NN
cord-017527-ylng1us2	196	41	.	.	.
cord-017527-ylng1us2	197	1	The	the	DT
cord-017527-ylng1us2	197	2	risk	risk	NN
cord-017527-ylng1us2	197	3	assessment	assessment	NN
cord-017527-ylng1us2	197	4	for	for	IN
cord-017527-ylng1us2	197	5	transgenes	transgene	NNS
cord-017527-ylng1us2	197	6	is	be	VBZ
cord-017527-ylng1us2	197	7	not	not	RB
cord-017527-ylng1us2	197	8	straightforward	straightforward	JJ
cord-017527-ylng1us2	197	9	and	and	CC
cord-017527-ylng1us2	197	10	demands	demand	VBZ
cord-017527-ylng1us2	197	11	appropriate	appropriate	JJ
cord-017527-ylng1us2	197	12	consideration	consideration	NN
cord-017527-ylng1us2	197	13	.	.	.
cord-017527-ylng1us2	198	1	Comprehensive	comprehensive	JJ
cord-017527-ylng1us2	198	2	reviews	review	NNS
cord-017527-ylng1us2	198	3	have	have	VBP
cord-017527-ylng1us2	198	4	specifically	specifically	RB
cord-017527-ylng1us2	198	5	addressed	address	VBN
cord-017527-ylng1us2	198	6	this	this	DT
cord-017527-ylng1us2	198	7	topic	topic	NN
cord-017527-ylng1us2	198	8	(	(	-LRB-
cord-017527-ylng1us2	198	9	Bergmans	Bergmans	NNPS
cord-017527-ylng1us2	198	10	et	et	FW
cord-017527-ylng1us2	198	11	al	al	NNP
cord-017527-ylng1us2	198	12	.	.	NNP
cord-017527-ylng1us2	198	13	2008	2008	CD
cord-017527-ylng1us2	198	14	;	;	:
cord-017527-ylng1us2	198	15	van	van	NNP
cord-017527-ylng1us2	198	16	den	den	NNP
cord-017527-ylng1us2	198	17	Akker	Akker	NNP
cord-017527-ylng1us2	198	18	et	et	NNP
cord-017527-ylng1us2	198	19	al	al	NNP
cord-017527-ylng1us2	198	20	.	.	NNP
cord-017527-ylng1us2	198	21	2013	2013	CD
cord-017527-ylng1us2	198	22	)	)	-RRB-
cord-017527-ylng1us2	198	23	.	.	.
cord-017527-ylng1us2	199	1	Genetic	genetic	JJ
cord-017527-ylng1us2	199	2	modification	modification	NN
cord-017527-ylng1us2	199	3	may	may	MD
cord-017527-ylng1us2	199	4	confer	confer	VB
cord-017527-ylng1us2	199	5	an	an	DT
cord-017527-ylng1us2	199	6	expanded	expand	VBN
cord-017527-ylng1us2	199	7	life	life	NN
cord-017527-ylng1us2	199	8	-	-	HYPH
cord-017527-ylng1us2	199	9	span	span	NN
cord-017527-ylng1us2	199	10	,	,	,
cord-017527-ylng1us2	199	11	immortalisation	immortalisation	NN
cord-017527-ylng1us2	199	12	or	or	CC
cord-017527-ylng1us2	199	13	increased	increase	VBN
cord-017527-ylng1us2	199	14	capacity	capacity	NN
cord-017527-ylng1us2	199	15	for	for	IN
cord-017527-ylng1us2	199	16	tumour	tumour	NN
cord-017527-ylng1us2	199	17	induction	induction	NN
cord-017527-ylng1us2	199	18	.	.	.
cord-017527-ylng1us2	200	1	However	however	RB
cord-017527-ylng1us2	200	2	,	,	,
cord-017527-ylng1us2	200	3	it	-PRON-	PRP
cord-017527-ylng1us2	200	4	is	be	VBZ
cord-017527-ylng1us2	200	5	unlikely	unlikely	JJ
cord-017527-ylng1us2	200	6	that	that	IN
cord-017527-ylng1us2	200	7	recombinant	recombinant	JJ
cord-017527-ylng1us2	200	8	properties	property	NNS
cord-017527-ylng1us2	200	9	obtained	obtain	VBN
cord-017527-ylng1us2	200	10	by	by	IN
cord-017527-ylng1us2	200	11	genetic	genetic	JJ
cord-017527-ylng1us2	200	12	modification	modification	NN
cord-017527-ylng1us2	200	13	may	may	MD
cord-017527-ylng1us2	200	14	have	have	VB
cord-017527-ylng1us2	200	15	an	an	DT
cord-017527-ylng1us2	200	16	adverse	adverse	JJ
cord-017527-ylng1us2	200	17	effect	effect	NN
cord-017527-ylng1us2	200	18	upon	upon	IN
cord-017527-ylng1us2	200	19	release	release	NN
cord-017527-ylng1us2	200	20	of	of	IN
cord-017527-ylng1us2	200	21	the	the	DT
cord-017527-ylng1us2	200	22	recombinant	recombinant	JJ
cord-017527-ylng1us2	200	23	animal	animal	NN
cord-017527-ylng1us2	200	24	or	or	CC
cord-017527-ylng1us2	200	25	human	human	JJ
cord-017527-ylng1us2	200	26	cells	cell	NNS
cord-017527-ylng1us2	200	27	into	into	IN
cord-017527-ylng1us2	200	28	the	the	DT
cord-017527-ylng1us2	200	29	environment	environment	NN
cord-017527-ylng1us2	200	30	.	.	.
cord-017527-ylng1us2	201	1	Cells	cell	NNS
cord-017527-ylng1us2	201	2	(	(	-LRB-
cord-017527-ylng1us2	201	3	genetically	genetically	RB
cord-017527-ylng1us2	201	4	modified	modify	VBN
cord-017527-ylng1us2	201	5	or	or	CC
cord-017527-ylng1us2	201	6	not	not	RB
cord-017527-ylng1us2	201	7	)	)	-RRB-
cord-017527-ylng1us2	201	8	have	have	VBP
cord-017527-ylng1us2	201	9	difficulties	difficulty	NNS
cord-017527-ylng1us2	201	10	to	to	TO
cord-017527-ylng1us2	201	11	survive	survive	VB
cord-017527-ylng1us2	201	12	in	in	IN
cord-017527-ylng1us2	201	13	a	a	DT
cord-017527-ylng1us2	201	14	hostile	hostile	JJ
cord-017527-ylng1us2	201	15	environment	environment	NN
cord-017527-ylng1us2	201	16	where	where	WRB
cord-017527-ylng1us2	201	17	control	control	NN
cord-017527-ylng1us2	201	18	of	of	IN
cord-017527-ylng1us2	201	19	temperature	temperature	NN
cord-017527-ylng1us2	201	20	and	and	CC
cord-017527-ylng1us2	201	21	osmolality	osmolality	NN
cord-017527-ylng1us2	201	22	is	be	VBZ
cord-017527-ylng1us2	201	23	lacking	lack	VBG
cord-017527-ylng1us2	201	24	or	or	CC
cord-017527-ylng1us2	201	25	where	where	WRB
cord-017527-ylng1us2	201	26	cell	cell	NN
cord-017527-ylng1us2	201	27	-	-	HYPH
cord-017527-ylng1us2	201	28	specific	specific	JJ
cord-017527-ylng1us2	201	29	nutrients	nutrient	NNS
cord-017527-ylng1us2	201	30	(	(	-LRB-
cord-017527-ylng1us2	202	1	e.g.	e.g.	IN
cord-017527-ylng1us2	202	2	glucose	glucose	NN
cord-017527-ylng1us2	202	3	,	,	,
cord-017527-ylng1us2	202	4	vitamins	vitamin	NNS
cord-017527-ylng1us2	202	5	,	,	,
cord-017527-ylng1us2	202	6	lipids	lipid	NNS
cord-017527-ylng1us2	202	7	)	)	-RRB-
cord-017527-ylng1us2	202	8	are	be	VBP
cord-017527-ylng1us2	202	9	not	not	RB
cord-017527-ylng1us2	202	10	balanced	balanced	JJ
cord-017527-ylng1us2	202	11	or	or	CC
cord-017527-ylng1us2	202	12	missing	missing	JJ
cord-017527-ylng1us2	202	13	.	.	.
cord-017527-ylng1us2	203	1	Hence	hence	RB
cord-017527-ylng1us2	203	2	,	,	,
cord-017527-ylng1us2	203	3	the	the	DT
cord-017527-ylng1us2	203	4	survival	survival	NN
cord-017527-ylng1us2	203	5	of	of	IN
cord-017527-ylng1us2	203	6	such	such	JJ
cord-017527-ylng1us2	203	7	primary	primary	JJ
cord-017527-ylng1us2	203	8	cells	cell	NNS
cord-017527-ylng1us2	203	9	or	or	CC
cord-017527-ylng1us2	203	10	cell	cell	NN
cord-017527-ylng1us2	203	11	lines	line	NNS
cord-017527-ylng1us2	203	12	outside	outside	RB
cord-017527-ylng1us2	203	13	of	of	IN
cord-017527-ylng1us2	203	14	proper	proper	JJ
cord-017527-ylng1us2	203	15	conditions	condition	NNS
cord-017527-ylng1us2	203	16	is	be	VBZ
cord-017527-ylng1us2	203	17	unlikely	unlikely	JJ
cord-017527-ylng1us2	203	18	to	to	TO
cord-017527-ylng1us2	203	19	occur	occur	VB
cord-017527-ylng1us2	203	20	.	.	.
cord-017527-ylng1us2	204	1	Apart	apart	RB
cord-017527-ylng1us2	204	2	from	from	IN
cord-017527-ylng1us2	204	3	the	the	DT
cord-017527-ylng1us2	204	4	fact	fact	NN
cord-017527-ylng1us2	204	5	that	that	IN
cord-017527-ylng1us2	204	6	GM	GM	NNP
cord-017527-ylng1us2	204	7	cell	cell	NN
cord-017527-ylng1us2	204	8	cultures	culture	NNS
cord-017527-ylng1us2	204	9	may	may	MD
cord-017527-ylng1us2	204	10	harbour	harbour	VB
cord-017527-ylng1us2	204	11	pathogens	pathogen	NNS
cord-017527-ylng1us2	204	12	and	and	CC
cord-017527-ylng1us2	204	13	pose	pose	VB
cord-017527-ylng1us2	204	14	serious	serious	JJ
cord-017527-ylng1us2	204	15	biological	biological	JJ
cord-017527-ylng1us2	204	16	risks	risk	NNS
cord-017527-ylng1us2	204	17	to	to	IN
cord-017527-ylng1us2	204	18	human	human	JJ
cord-017527-ylng1us2	204	19	health	health	NN
cord-017527-ylng1us2	204	20	(	(	-LRB-
cord-017527-ylng1us2	204	21	as	as	IN
cord-017527-ylng1us2	204	22	discussed	discuss	VBN
cord-017527-ylng1us2	204	23	above	above	RB
cord-017527-ylng1us2	204	24	)	)	-RRB-
cord-017527-ylng1us2	204	25	,	,	,
cord-017527-ylng1us2	204	26	recombinant	recombinant	JJ
cord-017527-ylng1us2	204	27	cells	cell	NNS
cord-017527-ylng1us2	204	28	are	be	VBP
cord-017527-ylng1us2	204	29	more	more	RBR
cord-017527-ylng1us2	204	30	likely	likely	JJ
cord-017527-ylng1us2	204	31	to	to	TO
cord-017527-ylng1us2	204	32	cause	cause	VB
cord-017527-ylng1us2	204	33	harm	harm	NN
cord-017527-ylng1us2	204	34	when	when	WRB
cord-017527-ylng1us2	204	35	entering	enter	VBG
cord-017527-ylng1us2	204	36	the	the	DT
cord-017527-ylng1us2	204	37	body	body	NN
cord-017527-ylng1us2	204	38	of	of	IN
cord-017527-ylng1us2	204	39	animals	animal	NNS
cord-017527-ylng1us2	204	40	or	or	CC
cord-017527-ylng1us2	204	41	humans	human	NNS
cord-017527-ylng1us2	204	42	.	.	.
cord-017527-ylng1us2	205	1	However	however	RB
cord-017527-ylng1us2	205	2	,	,	,
cord-017527-ylng1us2	205	3	the	the	DT
cord-017527-ylng1us2	205	4	extent	extent	NN
cord-017527-ylng1us2	205	5	of	of	IN
cord-017527-ylng1us2	205	6	the	the	DT
cord-017527-ylng1us2	205	7	harmful	harmful	JJ
cord-017527-ylng1us2	205	8	effect	effect	NN
cord-017527-ylng1us2	205	9	remains	remain	VBZ
cord-017527-ylng1us2	205	10	hard	hard	JJ
cord-017527-ylng1us2	205	11	to	to	TO
cord-017527-ylng1us2	205	12	predict	predict	VB
cord-017527-ylng1us2	205	13	.	.	.
cord-017527-ylng1us2	206	1	It	-PRON-	PRP
cord-017527-ylng1us2	206	2	should	should	MD
cord-017527-ylng1us2	206	3	be	be	VB
cord-017527-ylng1us2	206	4	kept	keep	VBN
cord-017527-ylng1us2	206	5	in	in	IN
cord-017527-ylng1us2	206	6	mind	mind	NN
cord-017527-ylng1us2	206	7	that	that	IN
cord-017527-ylng1us2	206	8	the	the	DT
cord-017527-ylng1us2	206	9	lack	lack	NN
cord-017527-ylng1us2	206	10	of	of	IN
cord-017527-ylng1us2	206	11	histocompatibility	histocompatibility	NN
cord-017527-ylng1us2	206	12	between	between	IN
cord-017527-ylng1us2	206	13	recombinant	recombinant	JJ
cord-017527-ylng1us2	206	14	cells	cell	NNS
cord-017527-ylng1us2	206	15	and	and	CC
cord-017527-ylng1us2	206	16	the	the	DT
cord-017527-ylng1us2	206	17	host	host	NN
cord-017527-ylng1us2	206	18	organism	organism	NN
cord-017527-ylng1us2	206	19	remains	remain	VBZ
cord-017527-ylng1us2	206	20	a	a	DT
cord-017527-ylng1us2	206	21	major	major	JJ
cord-017527-ylng1us2	206	22	obstacle	obstacle	NN
cord-017527-ylng1us2	206	23	for	for	IN
cord-017527-ylng1us2	206	24	these	these	DT
cord-017527-ylng1us2	206	25	cells	cell	NNS
cord-017527-ylng1us2	206	26	to	to	TO
cord-017527-ylng1us2	206	27	survive	survive	VB
cord-017527-ylng1us2	206	28	and	and	CC
cord-017527-ylng1us2	206	29	to	to	TO
cord-017527-ylng1us2	206	30	multiply	multiply	VB
cord-017527-ylng1us2	206	31	as	as	IN
cord-017527-ylng1us2	206	32	the	the	DT
cord-017527-ylng1us2	206	33	natural	natural	JJ
cord-017527-ylng1us2	206	34	immune	immune	JJ
cord-017527-ylng1us2	206	35	response	response	NN
cord-017527-ylng1us2	206	36	of	of	IN
cord-017527-ylng1us2	206	37	the	the	DT
cord-017527-ylng1us2	206	38	healthy	healthy	JJ
cord-017527-ylng1us2	206	39	(	(	-LRB-
cord-017527-ylng1us2	206	40	immunocompetent	immunocompetent	JJ
cord-017527-ylng1us2	206	41	)	)	-RRB-
cord-017527-ylng1us2	206	42	host	host	NN
cord-017527-ylng1us2	206	43	will	will	MD
cord-017527-ylng1us2	206	44	recognise	recognise	VB
cord-017527-ylng1us2	206	45	foreign	foreign	JJ
cord-017527-ylng1us2	206	46	cells	cell	NNS
cord-017527-ylng1us2	206	47	and	and	CC
cord-017527-ylng1us2	206	48	eventually	eventually	RB
cord-017527-ylng1us2	206	49	destroy	destroy	VB
cord-017527-ylng1us2	206	50	them	-PRON-	PRP
cord-017527-ylng1us2	206	51	.	.	.
cord-017527-ylng1us2	207	1	This	this	DT
cord-017527-ylng1us2	207	2	is	be	VBZ
cord-017527-ylng1us2	207	3	also	also	RB
cord-017527-ylng1us2	207	4	one	one	CD
cord-017527-ylng1us2	207	5	of	of	IN
cord-017527-ylng1us2	207	6	the	the	DT
cord-017527-ylng1us2	207	7	main	main	JJ
cord-017527-ylng1us2	207	8	reasons	reason	NNS
cord-017527-ylng1us2	207	9	why	why	WRB
cord-017527-ylng1us2	207	10	the	the	DT
cord-017527-ylng1us2	207	11	culturing	culturing	NN
cord-017527-ylng1us2	207	12	of	of	IN
cord-017527-ylng1us2	207	13	cells	cell	NNS
cord-017527-ylng1us2	207	14	originating	originate	VBG
cord-017527-ylng1us2	207	15	from	from	IN
cord-017527-ylng1us2	207	16	the	the	DT
cord-017527-ylng1us2	207	17	laboratory	laboratory	NN
cord-017527-ylng1us2	207	18	worker	worker	NN
cord-017527-ylng1us2	207	19	is	be	VBZ
cord-017527-ylng1us2	207	20	not	not	RB
cord-017527-ylng1us2	207	21	allowed	allow	VBN
cord-017527-ylng1us2	207	22	for	for	IN
cord-017527-ylng1us2	207	23	research	research	NN
cord-017527-ylng1us2	207	24	and	and	CC
cord-017527-ylng1us2	207	25	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	207	26	activities	activity	NNS
cord-017527-ylng1us2	207	27	(	(	-LRB-
cord-017527-ylng1us2	207	28	risk	risk	NN
cord-017527-ylng1us2	207	29	associated	associate	VBN
cord-017527-ylng1us2	207	30	with	with	IN
cord-017527-ylng1us2	207	31	autologous	autologous	JJ
cord-017527-ylng1us2	207	32	cells	cell	NNS
cord-017527-ylng1us2	207	33	)	)	-RRB-
cord-017527-ylng1us2	207	34	.	.	.
cord-017527-ylng1us2	208	1	Particular	particular	JJ
cord-017527-ylng1us2	208	2	attention	attention	NN
cord-017527-ylng1us2	208	3	should	should	MD
cord-017527-ylng1us2	208	4	be	be	VB
cord-017527-ylng1us2	208	5	paid	pay	VBN
cord-017527-ylng1us2	208	6	to	to	IN
cord-017527-ylng1us2	208	7	the	the	DT
cord-017527-ylng1us2	208	8	use	use	NN
cord-017527-ylng1us2	208	9	of	of	IN
cord-017527-ylng1us2	208	10	packaging	packaging	NN
cord-017527-ylng1us2	208	11	cell	cell	NN
cord-017527-ylng1us2	208	12	lines	line	NNS
cord-017527-ylng1us2	208	13	.	.	.
cord-017527-ylng1us2	209	1	These	these	DT
cord-017527-ylng1us2	209	2	are	be	VBP
cord-017527-ylng1us2	209	3	established	establish	VBN
cord-017527-ylng1us2	209	4	cell	cell	NN
cord-017527-ylng1us2	209	5	lines	line	NNS
cord-017527-ylng1us2	209	6	that	that	WDT
cord-017527-ylng1us2	209	7	are	be	VBP
cord-017527-ylng1us2	209	8	deliberately	deliberately	RB
cord-017527-ylng1us2	209	9	and	and	CC
cord-017527-ylng1us2	209	10	stably	stably	RB
cord-017527-ylng1us2	209	11	transfected	transfecte	VBN
cord-017527-ylng1us2	209	12	with	with	IN
cord-017527-ylng1us2	209	13	"	"	``
cord-017527-ylng1us2	209	14	helper	helper	NN
cord-017527-ylng1us2	209	15	constructs	construct	NNS
cord-017527-ylng1us2	209	16	"	"	''
cord-017527-ylng1us2	209	17	to	to	TO
cord-017527-ylng1us2	209	18	ensure	ensure	VB
cord-017527-ylng1us2	209	19	the	the	DT
cord-017527-ylng1us2	209	20	replication	replication	NN
cord-017527-ylng1us2	209	21	and	and	CC
cord-017527-ylng1us2	209	22	packaging	packaging	NN
cord-017527-ylng1us2	209	23	of	of	IN
cord-017527-ylng1us2	209	24	replication	replication	NN
cord-017527-ylng1us2	209	25	deficient	deficient	JJ
cord-017527-ylng1us2	209	26	viral	viral	JJ
cord-017527-ylng1us2	209	27	vectors	vector	NNS
cord-017527-ylng1us2	209	28	.	.	.
cord-017527-ylng1us2	210	1	For	for	IN
cord-017527-ylng1us2	210	2	example	example	NN
cord-017527-ylng1us2	210	3	,	,	,
cord-017527-ylng1us2	210	4	in	in	IN
cord-017527-ylng1us2	210	5	case	case	NN
cord-017527-ylng1us2	210	6	of	of	IN
cord-017527-ylng1us2	210	7	retroviral	retroviral	JJ
cord-017527-ylng1us2	210	8	packaging	packaging	NN
cord-017527-ylng1us2	210	9	cell	cell	NN
cord-017527-ylng1us2	210	10	lines	line	NNS
cord-017527-ylng1us2	210	11	,	,	,
cord-017527-ylng1us2	210	12	the	the	DT
cord-017527-ylng1us2	210	13	expression	expression	NN
cord-017527-ylng1us2	210	14	of	of	IN
cord-017527-ylng1us2	210	15	"	"	``
cord-017527-ylng1us2	210	16	helper	helper	NN
cord-017527-ylng1us2	210	17	genes	gene	NNS
cord-017527-ylng1us2	210	18	"	"	''
cord-017527-ylng1us2	210	19	allows	allow	VBZ
cord-017527-ylng1us2	210	20	high	high	JJ
cord-017527-ylng1us2	210	21	-	-	HYPH
cord-017527-ylng1us2	210	22	level	level	NN
cord-017527-ylng1us2	210	23	constitutive	constitutive	JJ
cord-017527-ylng1us2	210	24	production	production	NN
cord-017527-ylng1us2	210	25	of	of	IN
cord-017527-ylng1us2	210	26	viral	viral	JJ
cord-017527-ylng1us2	210	27	proteins	protein	NNS
cord-017527-ylng1us2	210	28	(	(	-LRB-
cord-017527-ylng1us2	210	29	e.g.	e.g.	IN
cord-017527-ylng1us2	210	30	gag	gag	NN
cord-017527-ylng1us2	210	31	,	,	,
cord-017527-ylng1us2	210	32	pol	pol	NN
cord-017527-ylng1us2	210	33	and	and	CC
cord-017527-ylng1us2	210	34	env	env	NN
cord-017527-ylng1us2	210	35	proteins	protein	NNS
cord-017527-ylng1us2	210	36	)	)	-RRB-
cord-017527-ylng1us2	210	37	,	,	,
cord-017527-ylng1us2	210	38	which	which	WDT
cord-017527-ylng1us2	210	39	are	be	VBP
cord-017527-ylng1us2	210	40	missing	miss	VBG
cord-017527-ylng1us2	210	41	in	in	IN
cord-017527-ylng1us2	210	42	the	the	DT
cord-017527-ylng1us2	210	43	genome	genome	NN
cord-017527-ylng1us2	210	44	of	of	IN
cord-017527-ylng1us2	210	45	the	the	DT
cord-017527-ylng1us2	210	46	replication	replication	NN
cord-017527-ylng1us2	210	47	deficient	deficient	JJ
cord-017527-ylng1us2	210	48	viral	viral	JJ
cord-017527-ylng1us2	210	49	vector	vector	NN
cord-017527-ylng1us2	210	50	but	but	CC
cord-017527-ylng1us2	210	51	are	be	VBP
cord-017527-ylng1us2	210	52	crucial	crucial	JJ
cord-017527-ylng1us2	210	53	for	for	IN
cord-017527-ylng1us2	210	54	viral	viral	JJ
cord-017527-ylng1us2	210	55	replication	replication	NN
cord-017527-ylng1us2	210	56	.	.	.
cord-017527-ylng1us2	211	1	One	one	CD
cord-017527-ylng1us2	211	2	of	of	IN
cord-017527-ylng1us2	211	3	the	the	DT
cord-017527-ylng1us2	211	4	main	main	JJ
cord-017527-ylng1us2	211	5	biosafety	biosafety	NN
cord-017527-ylng1us2	211	6	issues	issue	NNS
cord-017527-ylng1us2	211	7	related	relate	VBN
cord-017527-ylng1us2	211	8	to	to	IN
cord-017527-ylng1us2	211	9	the	the	DT
cord-017527-ylng1us2	211	10	use	use	NN
cord-017527-ylng1us2	211	11	of	of	IN
cord-017527-ylng1us2	211	12	packaging	packaging	NN
cord-017527-ylng1us2	211	13	cell	cell	NN
cord-017527-ylng1us2	211	14	lines	line	NNS
cord-017527-ylng1us2	211	15	is	be	VBZ
cord-017527-ylng1us2	211	16	the	the	DT
cord-017527-ylng1us2	211	17	fact	fact	NN
cord-017527-ylng1us2	211	18	that	that	IN
cord-017527-ylng1us2	211	19	replication	replication	NN
cord-017527-ylng1us2	211	20	-	-	HYPH
cord-017527-ylng1us2	211	21	competent	competent	JJ
cord-017527-ylng1us2	211	22	viruses	virus	NNS
cord-017527-ylng1us2	211	23	may	may	MD
cord-017527-ylng1us2	211	24	be	be	VB
cord-017527-ylng1us2	211	25	generated	generate	VBN
cord-017527-ylng1us2	211	26	as	as	IN
cord-017527-ylng1us2	211	27	a	a	DT
cord-017527-ylng1us2	211	28	result	result	NN
cord-017527-ylng1us2	211	29	of	of	IN
cord-017527-ylng1us2	211	30	(	(	-LRB-
cord-017527-ylng1us2	211	31	homologous	homologous	JJ
cord-017527-ylng1us2	211	32	)	)	-RRB-
cord-017527-ylng1us2	211	33	recombination	recombination	NN
cord-017527-ylng1us2	211	34	between	between	IN
cord-017527-ylng1us2	211	35	the	the	DT
cord-017527-ylng1us2	211	36	replication	replication	NN
cord-017527-ylng1us2	211	37	deficient	deficient	JJ
cord-017527-ylng1us2	211	38	viral	viral	JJ
cord-017527-ylng1us2	211	39	vector	vector	NN
cord-017527-ylng1us2	211	40	and	and	CC
cord-017527-ylng1us2	211	41	viral	viral	JJ
cord-017527-ylng1us2	211	42	sequences	sequence	NNS
cord-017527-ylng1us2	211	43	present	present	JJ
cord-017527-ylng1us2	211	44	in	in	IN
cord-017527-ylng1us2	211	45	the	the	DT
cord-017527-ylng1us2	211	46	packaging	packaging	NN
cord-017527-ylng1us2	211	47	cell	cell	NN
cord-017527-ylng1us2	211	48	.	.	.
cord-017527-ylng1us2	212	1	These	these	DT
cord-017527-ylng1us2	212	2	events	event	NNS
cord-017527-ylng1us2	212	3	could	could	MD
cord-017527-ylng1us2	212	4	result	result	VB
cord-017527-ylng1us2	212	5	in	in	IN
cord-017527-ylng1us2	212	6	the	the	DT
cord-017527-ylng1us2	212	7	formation	formation	NN
cord-017527-ylng1us2	212	8	of	of	IN
cord-017527-ylng1us2	212	9	viruses	virus	NNS
cord-017527-ylng1us2	212	10	with	with	IN
cord-017527-ylng1us2	212	11	novel	novel	NN
cord-017527-ylng1us2	212	12	yet	yet	CC
cord-017527-ylng1us2	212	13	unwanted	unwanted	JJ
cord-017527-ylng1us2	212	14	properties	property	NNS
cord-017527-ylng1us2	212	15	such	such	JJ
cord-017527-ylng1us2	212	16	as	as	IN
cord-017527-ylng1us2	212	17	the	the	DT
cord-017527-ylng1us2	212	18	generation	generation	NN
cord-017527-ylng1us2	212	19	of	of	IN
cord-017527-ylng1us2	212	20	replication	replication	NN
cord-017527-ylng1us2	212	21	-	-	HYPH
cord-017527-ylng1us2	212	22	competent	competent	JJ
cord-017527-ylng1us2	212	23	viruses	virus	NNS
cord-017527-ylng1us2	212	24	.	.	.
cord-017527-ylng1us2	213	1	One	one	CD
cord-017527-ylng1us2	213	2	of	of	IN
cord-017527-ylng1us2	213	3	the	the	DT
cord-017527-ylng1us2	213	4	strategies	strategy	NNS
cord-017527-ylng1us2	213	5	to	to	TO
cord-017527-ylng1us2	213	6	engineer	engineer	VB
cord-017527-ylng1us2	213	7	safer	safe	JJR
cord-017527-ylng1us2	213	8	generations	generation	NNS
cord-017527-ylng1us2	213	9	of	of	IN
cord-017527-ylng1us2	213	10	packaging	packaging	NN
cord-017527-ylng1us2	213	11	cell	cell	NN
cord-017527-ylng1us2	213	12	lines	line	NNS
cord-017527-ylng1us2	213	13	consists	consist	VBZ
cord-017527-ylng1us2	213	14	in	in	IN
cord-017527-ylng1us2	213	15	minimising	minimise	VBG
cord-017527-ylng1us2	213	16	the	the	DT
cord-017527-ylng1us2	213	17	likelihood	likelihood	NN
cord-017527-ylng1us2	213	18	of	of	IN
cord-017527-ylng1us2	213	19	generating	generate	VBG
cord-017527-ylng1us2	213	20	replication	replication	NN
cord-017527-ylng1us2	213	21	-	-	HYPH
cord-017527-ylng1us2	213	22	competent	competent	JJ
cord-017527-ylng1us2	213	23	viruses	virus	NNS
cord-017527-ylng1us2	213	24	by	by	IN
cord-017527-ylng1us2	213	25	separating	separate	VBG
cord-017527-ylng1us2	213	26	viral	viral	JJ
cord-017527-ylng1us2	213	27	functional	functional	JJ
cord-017527-ylng1us2	213	28	elements	element	NNS
cord-017527-ylng1us2	213	29	into	into	IN
cord-017527-ylng1us2	213	30	different	different	JJ
cord-017527-ylng1us2	213	31	expression	expression	NN
cord-017527-ylng1us2	213	32	plasmids	plasmid	NNS
cord-017527-ylng1us2	213	33	,	,	,
cord-017527-ylng1us2	213	34	thereby	thereby	RB
cord-017527-ylng1us2	213	35	increasing	increase	VBG
cord-017527-ylng1us2	213	36	the	the	DT
cord-017527-ylng1us2	213	37	number	number	NN
cord-017527-ylng1us2	213	38	of	of	IN
cord-017527-ylng1us2	213	39	recombination	recombination	NN
cord-017527-ylng1us2	213	40	events	event	NNS
cord-017527-ylng1us2	213	41	necessary	necessary	JJ
cord-017527-ylng1us2	213	42	to	to	TO
cord-017527-ylng1us2	213	43	generate	generate	VB
cord-017527-ylng1us2	213	44	replication	replication	NN
cord-017527-ylng1us2	213	45	-	-	HYPH
cord-017527-ylng1us2	213	46	competent	competent	JJ
cord-017527-ylng1us2	213	47	viruses	virus	NNS
cord-017527-ylng1us2	213	48	(	(	-LRB-
cord-017527-ylng1us2	213	49	Dull	dull	JJ
cord-017527-ylng1us2	213	50	et	et	FW
cord-017527-ylng1us2	213	51	al	al	NNP
cord-017527-ylng1us2	213	52	.	.	NNP
cord-017527-ylng1us2	213	53	1998	1998	CD
cord-017527-ylng1us2	213	54	)	)	-RRB-
cord-017527-ylng1us2	213	55	or	or	CC
cord-017527-ylng1us2	213	56	by	by	IN
cord-017527-ylng1us2	213	57	reducing	reduce	VBG
cord-017527-ylng1us2	213	58	or	or	CC
cord-017527-ylng1us2	213	59	eliminating	eliminate	VBG
cord-017527-ylng1us2	213	60	the	the	DT
cord-017527-ylng1us2	213	61	sequence	sequence	NN
cord-017527-ylng1us2	213	62	homology	homology	NN
cord-017527-ylng1us2	213	63	between	between	IN
cord-017527-ylng1us2	213	64	the	the	DT
cord-017527-ylng1us2	213	65	viral	viral	JJ
cord-017527-ylng1us2	213	66	vector	vector	NN
cord-017527-ylng1us2	213	67	and	and	CC
cord-017527-ylng1us2	213	68	the	the	DT
cord-017527-ylng1us2	213	69	helper	helper	NN
cord-017527-ylng1us2	213	70	sequences	sequence	NNS
cord-017527-ylng1us2	213	71	.	.	.
cord-017527-ylng1us2	214	1	However	however	RB
cord-017527-ylng1us2	214	2	,	,	,
cord-017527-ylng1us2	214	3	endogenous	endogenous	JJ
cord-017527-ylng1us2	214	4	retrovirus	retrovirus	NN
cord-017527-ylng1us2	214	5	genomes	genome	NNS
cord-017527-ylng1us2	214	6	expressed	express	VBN
cord-017527-ylng1us2	214	7	in	in	IN
cord-017527-ylng1us2	214	8	safer	safe	JJR
cord-017527-ylng1us2	214	9	generations	generation	NNS
cord-017527-ylng1us2	214	10	of	of	IN
cord-017527-ylng1us2	214	11	retroviral	retroviral	JJ
cord-017527-ylng1us2	214	12	packaging	packaging	NN
cord-017527-ylng1us2	214	13	cell	cell	NN
cord-017527-ylng1us2	214	14	lines	line	NNS
cord-017527-ylng1us2	214	15	may	may	MD
cord-017527-ylng1us2	214	16	still	still	RB
cord-017527-ylng1us2	214	17	give	give	VB
cord-017527-ylng1us2	214	18	rise	rise	NN
cord-017527-ylng1us2	214	19	to	to	IN
cord-017527-ylng1us2	214	20	unwanted	unwanted	JJ
cord-017527-ylng1us2	214	21	recombination	recombination	NN
cord-017527-ylng1us2	214	22	events	event	NNS
cord-017527-ylng1us2	214	23	(	(	-LRB-
cord-017527-ylng1us2	214	24	Chong	Chong	NNP
cord-017527-ylng1us2	214	25	et	et	NNP
cord-017527-ylng1us2	214	26	al	al	NNP
cord-017527-ylng1us2	214	27	.	.	NNP
cord-017527-ylng1us2	214	28	1998	1998	CD
cord-017527-ylng1us2	214	29	)	)	-RRB-
cord-017527-ylng1us2	214	30	.	.	.
cord-017527-ylng1us2	215	1	This	this	DT
cord-017527-ylng1us2	215	2	means	mean	VBZ
cord-017527-ylng1us2	215	3	that	that	IN
cord-017527-ylng1us2	215	4	the	the	DT
cord-017527-ylng1us2	215	5	possibility	possibility	NN
cord-017527-ylng1us2	215	6	to	to	TO
cord-017527-ylng1us2	215	7	generate	generate	VB
cord-017527-ylng1us2	215	8	replication	replication	NN
cord-017527-ylng1us2	215	9	-	-	HYPH
cord-017527-ylng1us2	215	10	competent	competent	JJ
cord-017527-ylng1us2	215	11	viruses	virus	NNS
cord-017527-ylng1us2	215	12	can	can	MD
cord-017527-ylng1us2	215	13	not	not	RB
cord-017527-ylng1us2	215	14	be	be	VB
cord-017527-ylng1us2	215	15	ruled	rule	VBN
cord-017527-ylng1us2	215	16	out	out	RP
cord-017527-ylng1us2	215	17	.	.	.
cord-017527-ylng1us2	216	1	Clearly	clearly	RB
cord-017527-ylng1us2	216	2	,	,	,
cord-017527-ylng1us2	216	3	the	the	DT
cord-017527-ylng1us2	216	4	risk	risk	NN
cord-017527-ylng1us2	216	5	group	group	NN
cord-017527-ylng1us2	216	6	of	of	IN
cord-017527-ylng1us2	216	7	the	the	DT
cord-017527-ylng1us2	216	8	transfected	transfecte	VBN
cord-017527-ylng1us2	216	9	packaging	packaging	NN
cord-017527-ylng1us2	216	10	cell	cell	NN
cord-017527-ylng1us2	216	11	line	line	NN
cord-017527-ylng1us2	216	12	will	will	MD
cord-017527-ylng1us2	216	13	depend	depend	VB
cord-017527-ylng1us2	216	14	on	on	IN
cord-017527-ylng1us2	216	15	the	the	DT
cord-017527-ylng1us2	216	16	risk	risk	NN
cord-017527-ylng1us2	216	17	group	group	NN
cord-017527-ylng1us2	216	18	of	of	IN
cord-017527-ylng1us2	216	19	the	the	DT
cord-017527-ylng1us2	216	20	viral	viral	JJ
cord-017527-ylng1us2	216	21	vector	vector	NN
cord-017527-ylng1us2	216	22	itself	-PRON-	PRP
cord-017527-ylng1us2	216	23	.	.	.
cord-017527-ylng1us2	217	1	Consequently	consequently	RB
cord-017527-ylng1us2	217	2	,	,	,
cord-017527-ylng1us2	217	3	risk	risk	NN
cord-017527-ylng1us2	217	4	assessment	assessment	NN
cord-017527-ylng1us2	217	5	of	of	IN
cord-017527-ylng1us2	217	6	packaging	packaging	NN
cord-017527-ylng1us2	217	7	cell	cell	NN
cord-017527-ylng1us2	217	8	lines	line	NNS
cord-017527-ylng1us2	217	9	should	should	MD
cord-017527-ylng1us2	217	10	be	be	VB
cord-017527-ylng1us2	217	11	based	base	VBN
cord-017527-ylng1us2	217	12	on	on	IN
cord-017527-ylng1us2	217	13	the	the	DT
cord-017527-ylng1us2	217	14	biosafety	biosafety	NN
cord-017527-ylng1us2	217	15	of	of	IN
cord-017527-ylng1us2	217	16	the	the	DT
cord-017527-ylng1us2	217	17	produced	produce	VBN
cord-017527-ylng1us2	217	18	viral	viral	JJ
cord-017527-ylng1us2	217	19	vectors	vector	NNS
cord-017527-ylng1us2	217	20	,	,	,
cord-017527-ylng1us2	217	21	including	include	VBG
cord-017527-ylng1us2	217	22	an	an	DT
cord-017527-ylng1us2	217	23	evaluation	evaluation	NN
cord-017527-ylng1us2	217	24	of	of	IN
cord-017527-ylng1us2	217	25	their	-PRON-	PRP$
cord-017527-ylng1us2	217	26	infectivity	infectivity	NN
cord-017527-ylng1us2	217	27	,	,	,
cord-017527-ylng1us2	217	28	spectrum	spectrum	NN
cord-017527-ylng1us2	217	29	of	of	IN
cord-017527-ylng1us2	217	30	host	host	NN
cord-017527-ylng1us2	217	31	range	range	NN
cord-017527-ylng1us2	217	32	,	,	,
cord-017527-ylng1us2	217	33	capacity	capacity	NN
cord-017527-ylng1us2	217	34	of	of	IN
cord-017527-ylng1us2	217	35	integration	integration	NN
cord-017527-ylng1us2	217	36	(	(	-LRB-
cord-017527-ylng1us2	217	37	insertional	insertional	NNP
cord-017527-ylng1us2	217	38	mutagenesis	mutagenesis	NNP
cord-017527-ylng1us2	217	39	)	)	-RRB-
cord-017527-ylng1us2	217	40	,	,	,
cord-017527-ylng1us2	217	41	stability	stability	NN
cord-017527-ylng1us2	217	42	and	and	CC
cord-017527-ylng1us2	217	43	physiological	physiological	JJ
cord-017527-ylng1us2	217	44	role	role	NN
cord-017527-ylng1us2	217	45	of	of	IN
cord-017527-ylng1us2	217	46	the	the	DT
cord-017527-ylng1us2	217	47	transgene(s	transgene(s	NNP
cord-017527-ylng1us2	217	48	)	)	-RRB-
cord-017527-ylng1us2	217	49	if	if	IN
cord-017527-ylng1us2	217	50	expressed	express	VBN
cord-017527-ylng1us2	217	51	(	(	-LRB-
cord-017527-ylng1us2	217	52	Baldo	Baldo	NNP
cord-017527-ylng1us2	217	53	et	et	NNP
cord-017527-ylng1us2	217	54	al	al	NNP
cord-017527-ylng1us2	217	55	.	.	NNP
cord-017527-ylng1us2	217	56	2013	2013	CD
cord-017527-ylng1us2	217	57	)	)	-RRB-
cord-017527-ylng1us2	217	58	.	.	.
cord-017527-ylng1us2	218	1	Aside	aside	RB
cord-017527-ylng1us2	218	2	from	from	IN
cord-017527-ylng1us2	218	3	the	the	DT
cord-017527-ylng1us2	218	4	identification	identification	NN
cord-017527-ylng1us2	218	5	and	and	CC
cord-017527-ylng1us2	218	6	characterisation	characterisation	NN
cord-017527-ylng1us2	218	7	of	of	IN
cord-017527-ylng1us2	218	8	hazards	hazard	NNS
cord-017527-ylng1us2	218	9	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	218	10	to	to	IN
cord-017527-ylng1us2	218	11	the	the	DT
cord-017527-ylng1us2	218	12	cell	cell	NN
cord-017527-ylng1us2	218	13	culture	culture	NN
cord-017527-ylng1us2	218	14	,	,	,
cord-017527-ylng1us2	218	15	a	a	DT
cord-017527-ylng1us2	218	16	thorough	thorough	JJ
cord-017527-ylng1us2	218	17	risk	risk	NN
cord-017527-ylng1us2	218	18	assessment	assessment	NN
cord-017527-ylng1us2	218	19	must	must	MD
cord-017527-ylng1us2	218	20	also	also	RB
cord-017527-ylng1us2	218	21	consider	consider	VB
cord-017527-ylng1us2	218	22	the	the	DT
cord-017527-ylng1us2	218	23	exposure	exposure	NN
cord-017527-ylng1us2	218	24	pathways	pathway	NNS
cord-017527-ylng1us2	218	25	through	through	IN
cord-017527-ylng1us2	218	26	which	which	WDT
cord-017527-ylng1us2	218	27	cell	cell	NN
cord-017527-ylng1us2	218	28	cultures	culture	NNS
cord-017527-ylng1us2	218	29	may	may	MD
cord-017527-ylng1us2	218	30	present	present	VB
cord-017527-ylng1us2	218	31	a	a	DT
cord-017527-ylng1us2	218	32	risk	risk	NN
cord-017527-ylng1us2	218	33	to	to	IN
cord-017527-ylng1us2	218	34	human	human	JJ
cord-017527-ylng1us2	218	35	health	health	NN
cord-017527-ylng1us2	218	36	or	or	CC
cord-017527-ylng1us2	218	37	the	the	DT
cord-017527-ylng1us2	218	38	environment	environment	NN
cord-017527-ylng1us2	218	39	.	.	.
cord-017527-ylng1us2	219	1	This	this	DT
cord-017527-ylng1us2	219	2	necessitates	necessitate	VBZ
cord-017527-ylng1us2	219	3	an	an	DT
cord-017527-ylng1us2	219	4	evaluation	evaluation	NN
cord-017527-ylng1us2	219	5	of	of	IN
cord-017527-ylng1us2	219	6	the	the	DT
cord-017527-ylng1us2	219	7	type	type	NN
cord-017527-ylng1us2	219	8	of	of	IN
cord-017527-ylng1us2	219	9	manipulation	manipulation	NN
cord-017527-ylng1us2	219	10	,	,	,
cord-017527-ylng1us2	219	11	because	because	IN
cord-017527-ylng1us2	219	12	processes	process	NNS
cord-017527-ylng1us2	219	13	,	,	,
cord-017527-ylng1us2	219	14	methods	method	NNS
cord-017527-ylng1us2	219	15	and/or	and/or	CC
cord-017527-ylng1us2	219	16	equipment	equipment	NN
cord-017527-ylng1us2	219	17	involved	involve	VBN
cord-017527-ylng1us2	219	18	may	may	MD
cord-017527-ylng1us2	219	19	increase	increase	VB
cord-017527-ylng1us2	219	20	or	or	CC
cord-017527-ylng1us2	219	21	decrease	decrease	VB
cord-017527-ylng1us2	219	22	the	the	DT
cord-017527-ylng1us2	219	23	likelihood	likelihood	NN
cord-017527-ylng1us2	219	24	of	of	IN
cord-017527-ylng1us2	219	25	exposure	exposure	NN
cord-017527-ylng1us2	219	26	and	and	CC
cord-017527-ylng1us2	219	27	hence	hence	RB
cord-017527-ylng1us2	219	28	the	the	DT
cord-017527-ylng1us2	219	29	resulting	result	VBG
cord-017527-ylng1us2	219	30	potential	potential	JJ
cord-017527-ylng1us2	219	31	risks	risk	NNS
cord-017527-ylng1us2	219	32	.	.	.
cord-017527-ylng1us2	220	1	For	for	IN
cord-017527-ylng1us2	220	2	instance	instance	NN
cord-017527-ylng1us2	220	3	,	,	,
cord-017527-ylng1us2	220	4	while	while	IN
cord-017527-ylng1us2	220	5	established	establish	VBN
cord-017527-ylng1us2	220	6	cell	cell	NN
cord-017527-ylng1us2	220	7	lines	line	NNS
cord-017527-ylng1us2	220	8	inherently	inherently	RB
cord-017527-ylng1us2	220	9	present	present	VBP
cord-017527-ylng1us2	220	10	low	low	JJ
cord-017527-ylng1us2	220	11	risks	risk	NNS
cord-017527-ylng1us2	220	12	,	,	,
cord-017527-ylng1us2	220	13	large	large	JJ
cord-017527-ylng1us2	220	14	scale	scale	NN
cord-017527-ylng1us2	220	15	operations	operation	NNS
cord-017527-ylng1us2	220	16	involving	involve	VBG
cord-017527-ylng1us2	220	17	the	the	DT
cord-017527-ylng1us2	220	18	culturing	culturing	NN
cord-017527-ylng1us2	220	19	of	of	IN
cord-017527-ylng1us2	220	20	large	large	JJ
cord-017527-ylng1us2	220	21	volumes	volume	NNS
cord-017527-ylng1us2	220	22	(	(	-LRB-
cord-017527-ylng1us2	220	23	from	from	IN
cord-017527-ylng1us2	220	24	10	10	CD
cord-017527-ylng1us2	220	25	to	to	TO
cord-017527-ylng1us2	220	26	1,000	1,000	CD
cord-017527-ylng1us2	220	27	l	l	NN
cord-017527-ylng1us2	220	28	)	)	-RRB-
cord-017527-ylng1us2	220	29	are	be	VBP
cord-017527-ylng1us2	220	30	prone	prone	JJ
cord-017527-ylng1us2	220	31	to	to	IN
cord-017527-ylng1us2	220	32	contamination	contamination	NN
cord-017527-ylng1us2	220	33	when	when	WRB
cord-017527-ylng1us2	220	34	inadequate	inadequate	JJ
cord-017527-ylng1us2	220	35	containment	containment	NN
cord-017527-ylng1us2	220	36	measures	measure	NNS
cord-017527-ylng1us2	220	37	are	be	VBP
cord-017527-ylng1us2	220	38	applied	apply	VBN
cord-017527-ylng1us2	220	39	.	.	.
cord-017527-ylng1us2	221	1	This	this	DT
cord-017527-ylng1us2	221	2	is	be	VBZ
cord-017527-ylng1us2	221	3	exemplified	exemplify	VBN
cord-017527-ylng1us2	221	4	by	by	IN
cord-017527-ylng1us2	221	5	continuous	continuous	JJ
cord-017527-ylng1us2	221	6	processes	process	NNS
cord-017527-ylng1us2	221	7	such	such	JJ
cord-017527-ylng1us2	221	8	as	as	IN
cord-017527-ylng1us2	221	9	cell	cell	NN
cord-017527-ylng1us2	221	10	cultivation	cultivation	NN
cord-017527-ylng1us2	221	11	in	in	IN
cord-017527-ylng1us2	221	12	bioreactors	bioreactor	NNS
cord-017527-ylng1us2	221	13	where	where	WRB
cord-017527-ylng1us2	221	14	an	an	DT
cord-017527-ylng1us2	221	15	appropriate	appropriate	JJ
cord-017527-ylng1us2	221	16	design	design	NN
cord-017527-ylng1us2	221	17	of	of	IN
cord-017527-ylng1us2	221	18	seals	seal	NNS
cord-017527-ylng1us2	221	19	,	,	,
cord-017527-ylng1us2	221	20	valves	valve	NNS
cord-017527-ylng1us2	221	21	,	,	,
cord-017527-ylng1us2	221	22	pumps	pump	NNS
cord-017527-ylng1us2	221	23	and	and	CC
cord-017527-ylng1us2	221	24	transfer	transfer	NN
cord-017527-ylng1us2	221	25	lines	line	NNS
cord-017527-ylng1us2	221	26	is	be	VBZ
cord-017527-ylng1us2	221	27	required	require	VBN
cord-017527-ylng1us2	221	28	to	to	TO
cord-017527-ylng1us2	221	29	guarantee	guarantee	VB
cord-017527-ylng1us2	221	30	long	long	JJ
cord-017527-ylng1us2	221	31	-	-	HYPH
cord-017527-ylng1us2	221	32	term	term	NN
cord-017527-ylng1us2	221	33	sterility	sterility	NN
cord-017527-ylng1us2	221	34	of	of	IN
cord-017527-ylng1us2	221	35	the	the	DT
cord-017527-ylng1us2	221	36	operation	operation	NN
cord-017527-ylng1us2	221	37	to	to	TO
cord-017527-ylng1us2	221	38	avoid	avoid	VB
cord-017527-ylng1us2	221	39	inadvertent	inadvertent	JJ
cord-017527-ylng1us2	221	40	contamination	contamination	NN
cord-017527-ylng1us2	221	41	.	.	.
cord-017527-ylng1us2	222	1	At	at	IN
cord-017527-ylng1us2	222	2	the	the	DT
cord-017527-ylng1us2	222	3	opposite	opposite	NN
cord-017527-ylng1us2	222	4	,	,	,
cord-017527-ylng1us2	222	5	the	the	DT
cord-017527-ylng1us2	222	6	handling	handling	NN
cord-017527-ylng1us2	222	7	of	of	IN
cord-017527-ylng1us2	222	8	cell	cell	NN
cord-017527-ylng1us2	222	9	cultures	culture	NNS
cord-017527-ylng1us2	222	10	belonging	belong	VBG
cord-017527-ylng1us2	222	11	to	to	IN
cord-017527-ylng1us2	222	12	risk	risk	NN
cord-017527-ylng1us2	222	13	group	group	NN
cord-017527-ylng1us2	222	14	2	2	CD
cord-017527-ylng1us2	222	15	may	may	MD
cord-017527-ylng1us2	222	16	present	present	VB
cord-017527-ylng1us2	222	17	less	less	JJR
cord-017527-ylng1us2	222	18	risk	risk	NN
cord-017527-ylng1us2	222	19	once	once	IN
cord-017527-ylng1us2	222	20	they	-PRON-	PRP
cord-017527-ylng1us2	222	21	have	have	VBP
cord-017527-ylng1us2	222	22	been	be	VBN
cord-017527-ylng1us2	222	23	fixed	fix	VBN
cord-017527-ylng1us2	222	24	by	by	IN
cord-017527-ylng1us2	222	25	glutaraldehyde	glutaraldehyde	NN
cord-017527-ylng1us2	222	26	or	or	CC
cord-017527-ylng1us2	222	27	formaldehyde	formaldehyde	NN
cord-017527-ylng1us2	222	28	/	/	SYM
cord-017527-ylng1us2	222	29	acetone	acetone	NN
cord-017527-ylng1us2	222	30	for	for	IN
cord-017527-ylng1us2	222	31	immunostaining	immunostaining	NN
cord-017527-ylng1us2	222	32	and	and	CC
cord-017527-ylng1us2	222	33	may	may	MD
cord-017527-ylng1us2	222	34	therefore	therefore	RB
cord-017527-ylng1us2	222	35	require	require	VB
cord-017527-ylng1us2	222	36	less	less	RBR
cord-017527-ylng1us2	222	37	stringent	stringent	JJ
cord-017527-ylng1us2	222	38	containment	containment	NN
cord-017527-ylng1us2	222	39	measures	measure	NNS
cord-017527-ylng1us2	222	40	Manipulations	manipulation	NNS
cord-017527-ylng1us2	222	41	that	that	WDT
cord-017527-ylng1us2	222	42	are	be	VBP
cord-017527-ylng1us2	222	43	common	common	JJ
cord-017527-ylng1us2	222	44	to	to	TO
cord-017527-ylng1us2	222	45	research	research	NN
cord-017527-ylng1us2	222	46	and	and	CC
cord-017527-ylng1us2	222	47	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	222	48	activities	activity	NNS
cord-017527-ylng1us2	222	49	and	and	CC
cord-017527-ylng1us2	222	50	warrant	warrant	VB
cord-017527-ylng1us2	222	51	consideration	consideration	NN
cord-017527-ylng1us2	222	52	with	with	IN
cord-017527-ylng1us2	222	53	respect	respect	NN
cord-017527-ylng1us2	222	54	to	to	IN
cord-017527-ylng1us2	222	55	the	the	DT
cord-017527-ylng1us2	222	56	risk	risk	NN
cord-017527-ylng1us2	222	57	assessment	assessment	NN
cord-017527-ylng1us2	222	58	of	of	IN
cord-017527-ylng1us2	222	59	animal	animal	NN
cord-017527-ylng1us2	222	60	cell	cell	NN
cord-017527-ylng1us2	222	61	cultures	culture	NNS
cord-017527-ylng1us2	222	62	are	be	VBP
cord-017527-ylng1us2	222	63	described	describe	VBN
cord-017527-ylng1us2	222	64	hereunder	hereunder	RB
cord-017527-ylng1us2	222	65	:	:	:
cord-017527-ylng1us2	222	66	-Procedures	-procedure	VBZ
cord-017527-ylng1us2	222	67	generating	generate	VBG
cord-017527-ylng1us2	222	68	aerosols	aerosol	NNS
cord-017527-ylng1us2	222	69	:	:	:
cord-017527-ylng1us2	222	70	pipetting	pipette	VBG
cord-017527-ylng1us2	222	71	,	,	,
cord-017527-ylng1us2	222	72	vortexing	vortexing	NN
cord-017527-ylng1us2	222	73	,	,	,
cord-017527-ylng1us2	222	74	centrifugation	centrifugation	NN
cord-017527-ylng1us2	222	75	,	,	,
cord-017527-ylng1us2	222	76	opening	opening	NN
cord-017527-ylng1us2	222	77	of	of	IN
cord-017527-ylng1us2	222	78	wet	wet	JJ
cord-017527-ylng1us2	222	79	cups	cup	NNS
cord-017527-ylng1us2	222	80	,	,	,
cord-017527-ylng1us2	222	81	etc	etc	FW
cord-017527-ylng1us2	222	82	.	.	.
cord-017527-ylng1us2	223	1	;	;	:
cord-017527-ylng1us2	224	1	-Handling	-handle	VBG
cord-017527-ylng1us2	225	1	cells	cell	NNS
cord-017527-ylng1us2	225	2	outside	outside	RB
cord-017527-ylng1us2	225	3	of	of	IN
cord-017527-ylng1us2	225	4	a	a	DT
cord-017527-ylng1us2	225	5	class	class	NN
cord-017527-ylng1us2	225	6	II	II	NNP
cord-017527-ylng1us2	225	7	BSC	BSC	NNP
cord-017527-ylng1us2	225	8	:	:	:
cord-017527-ylng1us2	225	9	flow	flow	NNP
cord-017527-ylng1us2	225	10	cytometric	cytometric	NNP
cord-017527-ylng1us2	225	11	analysis	analysis	NN
cord-017527-ylng1us2	225	12	and	and	CC
cord-017527-ylng1us2	225	13	cell	cell	NN
cord-017527-ylng1us2	225	14	sorting	sorting	NN
cord-017527-ylng1us2	225	15	constitute	constitute	VBP
cord-017527-ylng1us2	225	16	a	a	DT
cord-017527-ylng1us2	225	17	special	special	JJ
cord-017527-ylng1us2	225	18	case	case	NN
cord-017527-ylng1us2	225	19	of	of	IN
cord-017527-ylng1us2	225	20	cell	cell	NN
cord-017527-ylng1us2	225	21	manipulation	manipulation	NN
cord-017527-ylng1us2	225	22	in	in	IN
cord-017527-ylng1us2	225	23	which	which	WDT
cord-017527-ylng1us2	225	24	cells	cell	NNS
cord-017527-ylng1us2	225	25	are	be	VBP
cord-017527-ylng1us2	225	26	handled	handle	VBN
cord-017527-ylng1us2	225	27	outside	outside	RB
cord-017527-ylng1us2	225	28	of	of	IN
cord-017527-ylng1us2	225	29	a	a	DT
cord-017527-ylng1us2	225	30	BSC	BSC	NNP
cord-017527-ylng1us2	225	31	.	.	.
cord-017527-ylng1us2	226	1	The	the	DT
cord-017527-ylng1us2	226	2	use	use	NN
cord-017527-ylng1us2	226	3	of	of	IN
cord-017527-ylng1us2	226	4	a	a	DT
cord-017527-ylng1us2	226	5	fixative	fixative	NN
cord-017527-ylng1us2	226	6	is	be	VBZ
cord-017527-ylng1us2	226	7	in	in	IN
cord-017527-ylng1us2	226	8	many	many	JJ
cord-017527-ylng1us2	226	9	cases	case	NNS
cord-017527-ylng1us2	226	10	not	not	RB
cord-017527-ylng1us2	226	11	appropriate	appropriate	JJ
cord-017527-ylng1us2	226	12	(	(	-LRB-
cord-017527-ylng1us2	226	13	e.g.	e.g.	DT
cord-017527-ylng1us2	226	14	viable	viable	JJ
cord-017527-ylng1us2	226	15	cell	cell	NN
cord-017527-ylng1us2	226	16	sorting	sort	VBG
cord-017527-ylng1us2	226	17	for	for	IN
cord-017527-ylng1us2	226	18	subsequent	subsequent	JJ
cord-017527-ylng1us2	226	19	further	further	JJ
cord-017527-ylng1us2	226	20	cell	cell	NN
cord-017527-ylng1us2	226	21	culturing	culturing	NN
cord-017527-ylng1us2	226	22	)	)	-RRB-
cord-017527-ylng1us2	226	23	and	and	CC
cord-017527-ylng1us2	226	24	the	the	DT
cord-017527-ylng1us2	226	25	risk	risk	NN
cord-017527-ylng1us2	226	26	of	of	IN
cord-017527-ylng1us2	226	27	aerosol	aerosol	NN
cord-017527-ylng1us2	226	28	formation	formation	NN
cord-017527-ylng1us2	226	29	can	can	MD
cord-017527-ylng1us2	226	30	be	be	VB
cord-017527-ylng1us2	226	31	particularly	particularly	RB
cord-017527-ylng1us2	226	32	high	high	JJ
cord-017527-ylng1us2	226	33	,	,	,
cord-017527-ylng1us2	226	34	especially	especially	RB
cord-017527-ylng1us2	226	35	during	during	IN
cord-017527-ylng1us2	226	36	sorting	sort	VBG
cord-017527-ylng1us2	226	37	experiments	experiment	NNS
cord-017527-ylng1us2	226	38	and	and	CC
cord-017527-ylng1us2	226	39	upon	upon	IN
cord-017527-ylng1us2	226	40	instrument	instrument	NN
cord-017527-ylng1us2	226	41	failure	failure	NN
cord-017527-ylng1us2	226	42	such	such	JJ
cord-017527-ylng1us2	226	43	as	as	IN
cord-017527-ylng1us2	226	44	a	a	DT
cord-017527-ylng1us2	226	45	clogged	clogged	JJ
cord-017527-ylng1us2	226	46	sort	sort	NN
cord-017527-ylng1us2	226	47	nozzle	nozzle	NN
cord-017527-ylng1us2	226	48	.	.	.
cord-017527-ylng1us2	227	1	All	all	DT
cord-017527-ylng1us2	227	2	scientists	scientist	NNS
cord-017527-ylng1us2	227	3	in	in	IN
cord-017527-ylng1us2	227	4	the	the	DT
cord-017527-ylng1us2	227	5	field	field	NN
cord-017527-ylng1us2	227	6	of	of	IN
cord-017527-ylng1us2	227	7	flow	flow	NN
cord-017527-ylng1us2	227	8	cytometry	cytometry	NN
cord-017527-ylng1us2	227	9	must	must	MD
cord-017527-ylng1us2	227	10	be	be	VB
cord-017527-ylng1us2	227	11	aware	aware	JJ
cord-017527-ylng1us2	227	12	of	of	IN
cord-017527-ylng1us2	227	13	the	the	DT
cord-017527-ylng1us2	227	14	potential	potential	JJ
cord-017527-ylng1us2	227	15	hazards	hazard	NNS
cord-017527-ylng1us2	227	16	associated	associate	VBN
cord-017527-ylng1us2	227	17	with	with	IN
cord-017527-ylng1us2	227	18	their	-PRON-	PRP$
cord-017527-ylng1us2	227	19	discipline	discipline	NN
cord-017527-ylng1us2	227	20	and	and	CC
cord-017527-ylng1us2	227	21	only	only	RB
cord-017527-ylng1us2	227	22	experienced	experienced	JJ
cord-017527-ylng1us2	227	23	and	and	CC
cord-017527-ylng1us2	227	24	well	well	RB
cord-017527-ylng1us2	227	25	-	-	HYPH
cord-017527-ylng1us2	227	26	trained	train	VBN
cord-017527-ylng1us2	227	27	operators	operator	NNS
cord-017527-ylng1us2	227	28	should	should	MD
cord-017527-ylng1us2	227	29	perform	perform	VB
cord-017527-ylng1us2	227	30	potentially	potentially	RB
cord-017527-ylng1us2	227	31	biohazardous	biohazardous	JJ
cord-017527-ylng1us2	227	32	cell	cell	NN
cord-017527-ylng1us2	227	33	sorting	sorting	NN
cord-017527-ylng1us2	227	34	.	.	.
cord-017527-ylng1us2	228	1	General	general	JJ
cord-017527-ylng1us2	228	2	recommendations	recommendation	NNS
cord-017527-ylng1us2	228	3	approved	approve	VBN
cord-017527-ylng1us2	228	4	by	by	IN
cord-017527-ylng1us2	228	5	the	the	DT
cord-017527-ylng1us2	228	6	International	International	NNP
cord-017527-ylng1us2	228	7	Society	Society	NNP
cord-017527-ylng1us2	228	8	of	of	IN
cord-017527-ylng1us2	228	9	Analytical	Analytical	NNP
cord-017527-ylng1us2	228	10	Cytology	Cytology	NNP
cord-017527-ylng1us2	228	11	should	should	MD
cord-017527-ylng1us2	228	12	help	help	VB
cord-017527-ylng1us2	228	13	to	to	TO
cord-017527-ylng1us2	228	14	set	set	VB
cord-017527-ylng1us2	228	15	a	a	DT
cord-017527-ylng1us2	228	16	basis	basis	NN
cord-017527-ylng1us2	228	17	for	for	IN
cord-017527-ylng1us2	228	18	biosafety	biosafety	NN
cord-017527-ylng1us2	228	19	guidelines	guideline	NNS
cord-017527-ylng1us2	228	20	in	in	IN
cord-017527-ylng1us2	228	21	flow	flow	NN
cord-017527-ylng1us2	228	22	cytometry	cytometry	NN
cord-017527-ylng1us2	228	23	laboratories	laboratory	NNS
cord-017527-ylng1us2	228	24	(	(	-LRB-
cord-017527-ylng1us2	228	25	Schmid	Schmid	NNP
cord-017527-ylng1us2	228	26	2012	2012	CD
cord-017527-ylng1us2	228	27	)	)	-RRB-
cord-017527-ylng1us2	228	28	.	.	.
cord-017527-ylng1us2	229	1	Some	some	DT
cord-017527-ylng1us2	229	2	standard	standard	JJ
cord-017527-ylng1us2	229	3	operating	operate	VBG
cord-017527-ylng1us2	229	4	procedures	procedure	NNS
cord-017527-ylng1us2	229	5	and	and	CC
cord-017527-ylng1us2	229	6	methods	method	NNS
cord-017527-ylng1us2	229	7	have	have	VBP
cord-017527-ylng1us2	229	8	also	also	RB
cord-017527-ylng1us2	229	9	been	be	VBN
cord-017527-ylng1us2	229	10	described	describe	VBN
cord-017527-ylng1us2	229	11	for	for	IN
cord-017527-ylng1us2	229	12	ensuring	ensure	VBG
cord-017527-ylng1us2	229	13	the	the	DT
cord-017527-ylng1us2	229	14	cell	cell	NN
cord-017527-ylng1us2	229	15	sorting	sort	VBG
cord-017527-ylng1us2	229	16	under	under	IN
cord-017527-ylng1us2	229	17	optimal	optimal	JJ
cord-017527-ylng1us2	229	18	biosafety	biosafety	NN
cord-017527-ylng1us2	229	19	conditions	condition	NNS
cord-017527-ylng1us2	229	20	even	even	RB
cord-017527-ylng1us2	229	21	under	under	IN
cord-017527-ylng1us2	229	22	BSL3	BSL3	NNP
cord-017527-ylng1us2	229	23	conditions	condition	NNS
cord-017527-ylng1us2	229	24	(	(	-LRB-
cord-017527-ylng1us2	229	25	Lennartz	Lennartz	NNP
cord-017527-ylng1us2	229	26	et	et	NNP
cord-017527-ylng1us2	229	27	al	al	NNP
cord-017527-ylng1us2	229	28	.	.	NNP
cord-017527-ylng1us2	229	29	2005	2005	CD
cord-017527-ylng1us2	229	30	;	;	:
cord-017527-ylng1us2	229	31	Perfetto	Perfetto	NNP
cord-017527-ylng1us2	229	32	et	et	FW
cord-017527-ylng1us2	229	33	al	al	NNP
cord-017527-ylng1us2	229	34	.	.	NNP
cord-017527-ylng1us2	229	35	2011	2011	CD
cord-017527-ylng1us2	229	36	)	)	-RRB-
cord-017527-ylng1us2	229	37	.	.	.
cord-017527-ylng1us2	230	1	-Altering	-altere	VBG
cord-017527-ylng1us2	231	1	culture	culture	NN
cord-017527-ylng1us2	231	2	conditions	condition	NNS
cord-017527-ylng1us2	231	3	:	:	:
cord-017527-ylng1us2	231	4	changing	change	VBG
cord-017527-ylng1us2	231	5	the	the	DT
cord-017527-ylng1us2	231	6	availability	availability	NN
cord-017527-ylng1us2	231	7	of	of	IN
cord-017527-ylng1us2	231	8	cell	cell	NN
cord-017527-ylng1us2	231	9	-	-	HYPH
cord-017527-ylng1us2	231	10	specific	specific	JJ
cord-017527-ylng1us2	231	11	nutrients	nutrient	NNS
cord-017527-ylng1us2	231	12	,	,	,
cord-017527-ylng1us2	231	13	growth	growth	NN
cord-017527-ylng1us2	231	14	factors	factor	NNS
cord-017527-ylng1us2	231	15	,	,	,
cord-017527-ylng1us2	231	16	signal	signal	NN
cord-017527-ylng1us2	231	17	molecules	molecule	NNS
cord-017527-ylng1us2	231	18	or	or	CC
cord-017527-ylng1us2	231	19	adopting	adopt	VBG
cord-017527-ylng1us2	231	20	co	co	NN
cord-017527-ylng1us2	231	21	-	-	NN
cord-017527-ylng1us2	231	22	culture	culture	NN
cord-017527-ylng1us2	231	23	techniques	technique	NNS
cord-017527-ylng1us2	231	24	may	may	MD
cord-017527-ylng1us2	231	25	have	have	VB
cord-017527-ylng1us2	231	26	significant	significant	JJ
cord-017527-ylng1us2	231	27	effects	effect	NNS
cord-017527-ylng1us2	231	28	on	on	IN
cord-017527-ylng1us2	231	29	animal	animal	NN
cord-017527-ylng1us2	231	30	cell	cell	NN
cord-017527-ylng1us2	231	31	cultures	culture	NNS
cord-017527-ylng1us2	231	32	as	as	IN
cord-017527-ylng1us2	231	33	it	-PRON-	PRP
cord-017527-ylng1us2	231	34	may	may	MD
cord-017527-ylng1us2	231	35	result	result	VB
cord-017527-ylng1us2	231	36	in	in	IN
cord-017527-ylng1us2	231	37	altered	alter	VBN
cord-017527-ylng1us2	231	38	neoplasia	neoplasia	NN
cord-017527-ylng1us2	231	39	(	(	-LRB-
cord-017527-ylng1us2	231	40	Stoker	Stoker	NNP
cord-017527-ylng1us2	231	41	et	et	NNP
cord-017527-ylng1us2	231	42	al	al	NNP
cord-017527-ylng1us2	231	43	.	.	NNP
cord-017527-ylng1us2	231	44	1990	1990	CD
cord-017527-ylng1us2	231	45	)	)	-RRB-
cord-017527-ylng1us2	231	46	,	,	,
cord-017527-ylng1us2	231	47	altered	alter	VBN
cord-017527-ylng1us2	231	48	expression	expression	NN
cord-017527-ylng1us2	231	49	of	of	IN
cord-017527-ylng1us2	231	50	(	(	-LRB-
cord-017527-ylng1us2	231	51	proto)onco	proto)onco	NNP
cord-017527-ylng1us2	231	52	-	-	HYPH
cord-017527-ylng1us2	231	53	genes	gene	NNS
cord-017527-ylng1us2	231	54	or	or	CC
cord-017527-ylng1us2	231	55	cell	cell	NN
cord-017527-ylng1us2	231	56	surface	surface	NN
cord-017527-ylng1us2	231	57	glycoproteins	glycoprotein	NNS
cord-017527-ylng1us2	231	58	and	and	CC
cord-017527-ylng1us2	231	59	release	release	NN
cord-017527-ylng1us2	231	60	of	of	IN
cord-017527-ylng1us2	231	61	endogenous	endogenous	JJ
cord-017527-ylng1us2	231	62	viruses	virus	NNS
cord-017527-ylng1us2	231	63	(	(	-LRB-
cord-017527-ylng1us2	231	64	Cunningham	Cunningham	NNP
cord-017527-ylng1us2	231	65	et	et	NNP
cord-017527-ylng1us2	231	66	al	al	NNP
cord-017527-ylng1us2	231	67	.	.	.
cord-017527-ylng1us2	231	68	2004	2004	CD
cord-017527-ylng1us2	231	69	)	)	-RRB-
cord-017527-ylng1us2	231	70	.	.	.
cord-017527-ylng1us2	232	1	As	as	IN
cord-017527-ylng1us2	232	2	a	a	DT
cord-017527-ylng1us2	232	3	consequence	consequence	NN
cord-017527-ylng1us2	232	4	,	,	,
cord-017527-ylng1us2	232	5	changing	change	VBG
cord-017527-ylng1us2	232	6	culture	culture	NN
cord-017527-ylng1us2	232	7	conditions	condition	NNS
cord-017527-ylng1us2	232	8	may	may	MD
cord-017527-ylng1us2	232	9	lead	lead	VB
cord-017527-ylng1us2	232	10	to	to	IN
cord-017527-ylng1us2	232	11	altered	alter	VBN
cord-017527-ylng1us2	232	12	susceptibility	susceptibility	NN
cord-017527-ylng1us2	232	13	of	of	IN
cord-017527-ylng1us2	232	14	cultured	cultured	JJ
cord-017527-ylng1us2	232	15	cells	cell	NNS
cord-017527-ylng1us2	232	16	to	to	IN
cord-017527-ylng1us2	232	17	biologic	biologic	JJ
cord-017527-ylng1us2	232	18	agents	agent	NNS
cord-017527-ylng1us2	232	19	such	such	JJ
cord-017527-ylng1us2	232	20	as	as	IN
cord-017527-ylng1us2	232	21	viruses	virus	NNS
cord-017527-ylng1us2	232	22	(	(	-LRB-
cord-017527-ylng1us2	232	23	Anders	Anders	NNP
cord-017527-ylng1us2	232	24	et	et	NNP
cord-017527-ylng1us2	232	25	al	al	NNP
cord-017527-ylng1us2	232	26	.	.	NNP
cord-017527-ylng1us2	232	27	2003	2003	CD
cord-017527-ylng1us2	232	28	;	;	:
cord-017527-ylng1us2	232	29	Vincent	Vincent	NNP
cord-017527-ylng1us2	232	30	et	et	NNP
cord-017527-ylng1us2	232	31	al	al	NNP
cord-017527-ylng1us2	232	32	.	.	.
cord-017527-ylng1us2	232	33	2004	2004	CD
cord-017527-ylng1us2	232	34	)	)	-RRB-
cord-017527-ylng1us2	232	35	.	.	.
cord-017527-ylng1us2	233	1	-Manipulations	-manipulation	NNS
cord-017527-ylng1us2	233	2	involving	involve	VBG
cord-017527-ylng1us2	233	3	use	use	NN
cord-017527-ylng1us2	233	4	of	of	IN
cord-017527-ylng1us2	233	5	needles	needle	NNS
cord-017527-ylng1us2	233	6	or	or	CC
cord-017527-ylng1us2	233	7	sharps	sharp	NNS
cord-017527-ylng1us2	233	8	:	:	:
cord-017527-ylng1us2	233	9	due	due	IN
cord-017527-ylng1us2	233	10	to	to	IN
cord-017527-ylng1us2	233	11	injuries	injury	NNS
cord-017527-ylng1us2	233	12	cell	cell	NN
cord-017527-ylng1us2	233	13	material	material	NN
cord-017527-ylng1us2	233	14	may	may	MD
cord-017527-ylng1us2	233	15	be	be	VB
cord-017527-ylng1us2	233	16	accidentally	accidentally	RB
cord-017527-ylng1us2	233	17	transferred	transfer	VBN
cord-017527-ylng1us2	233	18	directly	directly	RB
cord-017527-ylng1us2	233	19	to	to	IN
cord-017527-ylng1us2	233	20	an	an	DT
cord-017527-ylng1us2	233	21	operator	operator	NN
cord-017527-ylng1us2	233	22	's	's	POS
cord-017527-ylng1us2	233	23	tissue	tissue	NN
cord-017527-ylng1us2	233	24	and/or	and/or	CC
cord-017527-ylng1us2	233	25	blood	blood	NN
cord-017527-ylng1us2	233	26	stream	stream	NN
cord-017527-ylng1us2	233	27	.	.	.
cord-017527-ylng1us2	234	1	-In	-In	:
cord-017527-ylng1us2	234	2	vivo	vivo	NN
cord-017527-ylng1us2	234	3	experiments	experiment	NNS
cord-017527-ylng1us2	234	4	involving	involve	VBG
cord-017527-ylng1us2	234	5	animals	animal	NNS
cord-017527-ylng1us2	234	6	:	:	:
cord-017527-ylng1us2	235	1	major	major	JJ
cord-017527-ylng1us2	235	2	risks	risk	NNS
cord-017527-ylng1us2	235	3	are	be	VBP
cord-017527-ylng1us2	235	4	self	self	NN
cord-017527-ylng1us2	235	5	-	-	HYPH
cord-017527-ylng1us2	235	6	inoculation	inoculation	NN
cord-017527-ylng1us2	235	7	(	(	-LRB-
cord-017527-ylng1us2	235	8	needlestick	needlestick	NNP
cord-017527-ylng1us2	235	9	injury	injury	NN
cord-017527-ylng1us2	235	10	)	)	-RRB-
cord-017527-ylng1us2	235	11	and	and	CC
cord-017527-ylng1us2	235	12	exposure	exposure	NN
cord-017527-ylng1us2	235	13	to	to	IN
cord-017527-ylng1us2	235	14	aerosols	aerosol	NNS
cord-017527-ylng1us2	235	15	.	.	.
cord-017527-ylng1us2	236	1	Laboratory	laboratory	NN
cord-017527-ylng1us2	236	2	workers	worker	NNS
cord-017527-ylng1us2	236	3	handling	handle	VBG
cord-017527-ylng1us2	236	4	infected	infected	JJ
cord-017527-ylng1us2	236	5	rodents	rodent	NNS
cord-017527-ylng1us2	236	6	or	or	CC
cord-017527-ylng1us2	236	7	cell	cell	NN
cord-017527-ylng1us2	236	8	cultures	culture	NNS
cord-017527-ylng1us2	236	9	originating	originate	VBG
cord-017527-ylng1us2	236	10	from	from	IN
cord-017527-ylng1us2	236	11	infected	infected	JJ
cord-017527-ylng1us2	236	12	animals	animal	NNS
cord-017527-ylng1us2	236	13	expose	expose	VBP
cord-017527-ylng1us2	236	14	themselves	-PRON-	PRP
cord-017527-ylng1us2	236	15	at	at	IN
cord-017527-ylng1us2	236	16	risk	risk	NN
cord-017527-ylng1us2	236	17	by	by	IN
cord-017527-ylng1us2	236	18	directly	directly	RB
cord-017527-ylng1us2	236	19	exposing	expose	VBG
cord-017527-ylng1us2	236	20	cuts	cut	NNS
cord-017527-ylng1us2	236	21	,	,	,
cord-017527-ylng1us2	236	22	open	open	JJ
cord-017527-ylng1us2	236	23	wounds	wound	NNS
cord-017527-ylng1us2	236	24	or	or	CC
cord-017527-ylng1us2	236	25	mucus	mucus	NN
cord-017527-ylng1us2	236	26	membranes	membrane	NNS
cord-017527-ylng1us2	236	27	with	with	IN
cord-017527-ylng1us2	236	28	infected	infected	JJ
cord-017527-ylng1us2	236	29	body	body	NN
cord-017527-ylng1us2	236	30	fluids	fluid	NNS
cord-017527-ylng1us2	236	31	or	or	CC
cord-017527-ylng1us2	236	32	by	by	IN
cord-017527-ylng1us2	236	33	inhaling	inhale	VBG
cord-017527-ylng1us2	236	34	infectious	infectious	JJ
cord-017527-ylng1us2	236	35	aerosolized	aerosolize	VBN
cord-017527-ylng1us2	236	36	particles	particle	NNS
cord-017527-ylng1us2	236	37	of	of	IN
cord-017527-ylng1us2	236	38	rodent	rodent	NN
cord-017527-ylng1us2	236	39	urine	urine	NN
cord-017527-ylng1us2	236	40	,	,	,
cord-017527-ylng1us2	236	41	faeces	faece	NNS
cord-017527-ylng1us2	236	42	or	or	CC
cord-017527-ylng1us2	236	43	saliva	saliva	NN
cord-017527-ylng1us2	236	44	.	.	.
cord-017527-ylng1us2	237	1	The	the	DT
cord-017527-ylng1us2	237	2	risk	risk	NN
cord-017527-ylng1us2	237	3	can	can	MD
cord-017527-ylng1us2	237	4	be	be	VB
cord-017527-ylng1us2	237	5	minimised	minimise	VBN
cord-017527-ylng1us2	237	6	by	by	IN
cord-017527-ylng1us2	237	7	utilising	utilise	VBG
cord-017527-ylng1us2	237	8	animals	animal	NNS
cord-017527-ylng1us2	237	9	or	or	CC
cord-017527-ylng1us2	237	10	cell	cell	NN
cord-017527-ylng1us2	237	11	cultures	culture	NNS
cord-017527-ylng1us2	237	12	from	from	IN
cord-017527-ylng1us2	237	13	sources	source	NNS
cord-017527-ylng1us2	237	14	that	that	WDT
cord-017527-ylng1us2	237	15	are	be	VBP
cord-017527-ylng1us2	237	16	regularly	regularly	RB
cord-017527-ylng1us2	237	17	tested	test	VBN
cord-017527-ylng1us2	237	18	for	for	IN
cord-017527-ylng1us2	237	19	the	the	DT
cord-017527-ylng1us2	237	20	virus	virus	NN
cord-017527-ylng1us2	237	21	.	.	.
cord-017527-ylng1us2	238	1	Finally	finally	RB
cord-017527-ylng1us2	238	2	,	,	,
cord-017527-ylng1us2	238	3	the	the	DT
cord-017527-ylng1us2	238	4	purpose	purpose	NN
cord-017527-ylng1us2	238	5	of	of	IN
cord-017527-ylng1us2	238	6	cell	cell	NN
cord-017527-ylng1us2	238	7	culturing	culturing	NN
cord-017527-ylng1us2	238	8	should	should	MD
cord-017527-ylng1us2	238	9	be	be	VB
cord-017527-ylng1us2	238	10	taken	take	VBN
cord-017527-ylng1us2	238	11	into	into	IN
cord-017527-ylng1us2	238	12	consideration	consideration	NN
cord-017527-ylng1us2	238	13	as	as	IN
cord-017527-ylng1us2	238	14	many	many	JJ
cord-017527-ylng1us2	238	15	clinical	clinical	JJ
cord-017527-ylng1us2	238	16	approaches	approach	NNS
cord-017527-ylng1us2	238	17	such	such	JJ
cord-017527-ylng1us2	238	18	as	as	IN
cord-017527-ylng1us2	238	19	stem	stem	NN
cord-017527-ylng1us2	238	20	cell	cell	NN
cord-017527-ylng1us2	238	21	therapy	therapy	NN
cord-017527-ylng1us2	238	22	,	,	,
cord-017527-ylng1us2	238	23	gene	gene	NN
cord-017527-ylng1us2	238	24	therapy	therapy	NN
cord-017527-ylng1us2	238	25	,	,	,
cord-017527-ylng1us2	238	26	xeno	xeno	NNP
cord-017527-ylng1us2	238	27	-	-	:
cord-017527-ylng1us2	238	28	or	or	CC
cord-017527-ylng1us2	238	29	allotransplantation	allotransplantation	NN
cord-017527-ylng1us2	238	30	involve	involve	VBP
cord-017527-ylng1us2	238	31	cell	cell	NN
cord-017527-ylng1us2	238	32	culturing	culture	VBG
cord-017527-ylng1us2	238	33	ex	ex	FW
cord-017527-ylng1us2	238	34	vivo	vivo	NN
cord-017527-ylng1us2	238	35	for	for	IN
cord-017527-ylng1us2	238	36	therapeutic	therapeutic	JJ
cord-017527-ylng1us2	238	37	purposes	purpose	NNS
cord-017527-ylng1us2	238	38	.	.	.
cord-017527-ylng1us2	239	1	This	this	DT
cord-017527-ylng1us2	239	2	latter	latter	RB
cord-017527-ylng1us2	239	3	clearly	clearly	RB
cord-017527-ylng1us2	239	4	justifies	justify	VBZ
cord-017527-ylng1us2	239	5	more	more	RBR
cord-017527-ylng1us2	239	6	careful	careful	JJ
cord-017527-ylng1us2	239	7	consideration	consideration	NN
cord-017527-ylng1us2	239	8	regarding	regard	VBG
cord-017527-ylng1us2	239	9	safety	safety	NN
cord-017527-ylng1us2	239	10	,	,	,
cord-017527-ylng1us2	239	11	ethical	ethical	JJ
cord-017527-ylng1us2	239	12	,	,	,
cord-017527-ylng1us2	239	13	social	social	JJ
cord-017527-ylng1us2	239	14	and	and	CC
cord-017527-ylng1us2	239	15	regulatory	regulatory	JJ
cord-017527-ylng1us2	239	16	issues	issue	NNS
cord-017527-ylng1us2	239	17	,	,	,
cord-017527-ylng1us2	239	18	which	which	WDT
cord-017527-ylng1us2	239	19	will	will	MD
cord-017527-ylng1us2	239	20	not	not	RB
cord-017527-ylng1us2	239	21	be	be	VB
cord-017527-ylng1us2	239	22	addressed	address	VBN
cord-017527-ylng1us2	239	23	in	in	IN
cord-017527-ylng1us2	239	24	this	this	DT
cord-017527-ylng1us2	239	25	chapter	chapter	NN
cord-017527-ylng1us2	239	26	(	(	-LRB-
cord-017527-ylng1us2	239	27	Food	Food	NNP
cord-017527-ylng1us2	239	28	and	and	CC
cord-017527-ylng1us2	239	29	Drug	Drug	NNP
cord-017527-ylng1us2	239	30	Administration	Administration	NNP
cord-017527-ylng1us2	239	31	;	;	:
cord-017527-ylng1us2	239	32	European	European	NNP
cord-017527-ylng1us2	239	33	Medicines	Medicines	NNPS
cord-017527-ylng1us2	239	34	Agency	Agency	NNP
cord-017527-ylng1us2	239	35	;	;	:
cord-017527-ylng1us2	239	36	ICH	ICH	NNP
cord-017527-ylng1us2	239	37	1997	1997	CD
cord-017527-ylng1us2	239	38	)	)	-RRB-
cord-017527-ylng1us2	239	39	.	.	.
cord-017527-ylng1us2	240	1	The	the	DT
cord-017527-ylng1us2	240	2	assessment	assessment	NN
cord-017527-ylng1us2	240	3	of	of	IN
cord-017527-ylng1us2	240	4	biological	biological	JJ
cord-017527-ylng1us2	240	5	risks	risk	NNS
cord-017527-ylng1us2	240	6	related	relate	VBN
cord-017527-ylng1us2	240	7	to	to	IN
cord-017527-ylng1us2	240	8	animal	animal	NN
cord-017527-ylng1us2	240	9	cell	cell	NN
cord-017527-ylng1us2	240	10	cultures	culture	NNS
cord-017527-ylng1us2	240	11	and	and	CC
cord-017527-ylng1us2	240	12	the	the	DT
cord-017527-ylng1us2	240	13	type	type	NN
cord-017527-ylng1us2	240	14	of	of	IN
cord-017527-ylng1us2	240	15	manipulation	manipulation	NN
cord-017527-ylng1us2	240	16	allows	allow	VBZ
cord-017527-ylng1us2	240	17	the	the	DT
cord-017527-ylng1us2	240	18	determination	determination	NN
cord-017527-ylng1us2	240	19	of	of	IN
cord-017527-ylng1us2	240	20	an	an	DT
cord-017527-ylng1us2	240	21	adequate	adequate	JJ
cord-017527-ylng1us2	240	22	containment	containment	NN
cord-017527-ylng1us2	240	23	level	level	NN
cord-017527-ylng1us2	240	24	in	in	IN
cord-017527-ylng1us2	240	25	order	order	NN
cord-017527-ylng1us2	240	26	to	to	TO
cord-017527-ylng1us2	240	27	optimally	optimally	RB
cord-017527-ylng1us2	240	28	protect	protect	VB
cord-017527-ylng1us2	240	29	human	human	JJ
cord-017527-ylng1us2	240	30	health	health	NN
cord-017527-ylng1us2	240	31	and	and	CC
cord-017527-ylng1us2	240	32	the	the	DT
cord-017527-ylng1us2	240	33	environment	environment	NN
cord-017527-ylng1us2	240	34	.	.	.
cord-017527-ylng1us2	241	1	The	the	DT
cord-017527-ylng1us2	241	2	implementation	implementation	NN
cord-017527-ylng1us2	241	3	of	of	IN
cord-017527-ylng1us2	241	4	an	an	DT
cord-017527-ylng1us2	241	5	appropriate	appropriate	JJ
cord-017527-ylng1us2	241	6	containment	containment	NN
cord-017527-ylng1us2	241	7	level	level	NN
cord-017527-ylng1us2	241	8	includes	include	VBZ
cord-017527-ylng1us2	241	9	a	a	DT
cord-017527-ylng1us2	241	10	list	list	NN
cord-017527-ylng1us2	241	11	of	of	IN
cord-017527-ylng1us2	241	12	general	general	JJ
cord-017527-ylng1us2	241	13	and	and	CC
cord-017527-ylng1us2	241	14	more	more	RBR
cord-017527-ylng1us2	241	15	specific	specific	JJ
cord-017527-ylng1us2	241	16	work	work	NN
cord-017527-ylng1us2	241	17	practices	practice	NNS
cord-017527-ylng1us2	241	18	and	and	CC
cord-017527-ylng1us2	241	19	containment	containment	NN
cord-017527-ylng1us2	241	20	measures	measure	NNS
cord-017527-ylng1us2	241	21	.	.	.
cord-017527-ylng1us2	242	1	Table	table	NN
cord-017527-ylng1us2	242	2	22	22	CD
cord-017527-ylng1us2	242	3	.2	.2	CD
cord-017527-ylng1us2	242	4	lists	list	VBZ
cord-017527-ylng1us2	242	5	precautionary	precautionary	JJ
cord-017527-ylng1us2	242	6	measures	measure	NNS
cord-017527-ylng1us2	242	7	that	that	WDT
cord-017527-ylng1us2	242	8	should	should	MD
cord-017527-ylng1us2	242	9	be	be	VB
cord-017527-ylng1us2	242	10	applied	apply	VBN
cord-017527-ylng1us2	242	11	whenever	whenever	WRB
cord-017527-ylng1us2	242	12	handling	handle	VBG
cord-017527-ylng1us2	242	13	animal	animal	NN
cord-017527-ylng1us2	242	14	cell	cell	NN
cord-017527-ylng1us2	242	15	cultures	culture	NNS
cord-017527-ylng1us2	242	16	.	.	.
cord-017527-ylng1us2	243	1	Much	much	JJ
cord-017527-ylng1us2	243	2	of	of	IN
cord-017527-ylng1us2	243	3	these	these	DT
cord-017527-ylng1us2	243	4	measures	measure	NNS
cord-017527-ylng1us2	243	5	focus	focus	VBP
cord-017527-ylng1us2	243	6	on	on	IN
cord-017527-ylng1us2	243	7	reducing	reduce	VBG
cord-017527-ylng1us2	243	8	the	the	DT
cord-017527-ylng1us2	243	9	risk	risk	NN
cord-017527-ylng1us2	243	10	of	of	IN
cord-017527-ylng1us2	243	11	contamination	contamination	NN
cord-017527-ylng1us2	243	12	with	with	IN
cord-017527-ylng1us2	243	13	adventitious	adventitious	JJ
cord-017527-ylng1us2	243	14	agents	agent	NNS
cord-017527-ylng1us2	243	15	.	.	.
cord-017527-ylng1us2	244	1	It	-PRON-	PRP
cord-017527-ylng1us2	244	2	should	should	MD
cord-017527-ylng1us2	244	3	be	be	VB
cord-017527-ylng1us2	244	4	emphasised	emphasise	VBN
cord-017527-ylng1us2	244	5	that	that	IN
cord-017527-ylng1us2	244	6	the	the	DT
cord-017527-ylng1us2	244	7	drawn	draw	VBN
cord-017527-ylng1us2	244	8	-	-	HYPH
cord-017527-ylng1us2	244	9	up	up	NN
cord-017527-ylng1us2	244	10	of	of	IN
cord-017527-ylng1us2	244	11	an	an	DT
cord-017527-ylng1us2	244	12	appropriate	appropriate	JJ
cord-017527-ylng1us2	244	13	set	set	NN
cord-017527-ylng1us2	244	14	of	of	IN
cord-017527-ylng1us2	244	15	standard	standard	JJ
cord-017527-ylng1us2	244	16	operating	operating	NN
cord-017527-ylng1us2	244	17	procedures	procedure	NNS
cord-017527-ylng1us2	244	18	and	and	CC
cord-017527-ylng1us2	244	19	adequate	adequate	JJ
cord-017527-ylng1us2	244	20	training	training	NN
cord-017527-ylng1us2	244	21	of	of	IN
cord-017527-ylng1us2	244	22	the	the	DT
cord-017527-ylng1us2	244	23	staff	staff	NN
cord-017527-ylng1us2	244	24	is	be	VBZ
cord-017527-ylng1us2	244	25	of	of	IN
cord-017527-ylng1us2	244	26	crucial	crucial	JJ
cord-017527-ylng1us2	244	27	importance	importance	NN
cord-017527-ylng1us2	244	28	.	.	.
cord-017527-ylng1us2	245	1	As	as	IN
cord-017527-ylng1us2	245	2	a	a	DT
cord-017527-ylng1us2	245	3	general	general	JJ
cord-017527-ylng1us2	245	4	rule	rule	NN
cord-017527-ylng1us2	245	5	,	,	,
cord-017527-ylng1us2	245	6	cell	cell	NN
cord-017527-ylng1us2	245	7	cultures	culture	NNS
cord-017527-ylng1us2	245	8	known	know	VBN
cord-017527-ylng1us2	245	9	to	to	TO
cord-017527-ylng1us2	245	10	harbour	harbour	VB
cord-017527-ylng1us2	245	11	an	an	DT
cord-017527-ylng1us2	245	12	infectious	infectious	JJ
cord-017527-ylng1us2	245	13	etiologic	etiologic	JJ
cord-017527-ylng1us2	245	14	agent	agent	NN
cord-017527-ylng1us2	245	15	should	should	MD
cord-017527-ylng1us2	245	16	be	be	VB
cord-017527-ylng1us2	245	17	manipulated	manipulate	VBN
cord-017527-ylng1us2	245	18	in	in	IN
cord-017527-ylng1us2	245	19	compliance	compliance	NN
cord-017527-ylng1us2	245	20	with	with	IN
cord-017527-ylng1us2	245	21	containment	containment	NN
cord-017527-ylng1us2	245	22	measures	measure	NNS
cord-017527-ylng1us2	245	23	recommended	recommend	VBN
cord-017527-ylng1us2	245	24	for	for	IN
cord-017527-ylng1us2	245	25	the	the	DT
cord-017527-ylng1us2	245	26	etiologic	etiologic	JJ
cord-017527-ylng1us2	245	27	agent	agent	NN
cord-017527-ylng1us2	245	28	.	.	.
cord-017527-ylng1us2	246	1	When	when	WRB
cord-017527-ylng1us2	246	2	cell	cell	NN
cord-017527-ylng1us2	246	3	cultures	culture	NNS
cord-017527-ylng1us2	246	4	are	be	VBP
cord-017527-ylng1us2	246	5	not	not	RB
cord-017527-ylng1us2	246	6	known	know	VBN
cord-017527-ylng1us2	246	7	to	to	TO
cord-017527-ylng1us2	246	8	harbour	harbour	VB
cord-017527-ylng1us2	246	9	infectious	infectious	JJ
cord-017527-ylng1us2	246	10	agents	agent	NNS
cord-017527-ylng1us2	246	11	,	,	,
cord-017527-ylng1us2	246	12	cells	cell	NNS
cord-017527-ylng1us2	246	13	may	may	MD
cord-017527-ylng1us2	246	14	be	be	VB
cord-017527-ylng1us2	246	15	considered	consider	VBN
cord-017527-ylng1us2	246	16	free	free	JJ
cord-017527-ylng1us2	246	17	of	of	IN
cord-017527-ylng1us2	246	18	contaminating	contaminate	VBG
cord-017527-ylng1us2	246	19	pathogens	pathogen	NNS
cord-017527-ylng1us2	246	20	as	as	RB
cord-017527-ylng1us2	246	21	long	long	RB
cord-017527-ylng1us2	246	22	as	as	IN
cord-017527-ylng1us2	246	23	a	a	DT
cord-017527-ylng1us2	246	24	number	number	NN
cord-017527-ylng1us2	246	25	of	of	IN
cord-017527-ylng1us2	246	26	conditions	condition	NNS
cord-017527-ylng1us2	246	27	are	be	VBP
cord-017527-ylng1us2	246	28	fulfilled	fulfil	VBN
cord-017527-ylng1us2	246	29	.	.	.
cord-017527-ylng1us2	247	1	This	this	DT
cord-017527-ylng1us2	247	2	implies	imply	VBZ
cord-017527-ylng1us2	247	3	the	the	DT
cord-017527-ylng1us2	247	4	use	use	NN
cord-017527-ylng1us2	247	5	of	of	IN
cord-017527-ylng1us2	247	6	well	well	RB
cord-017527-ylng1us2	247	7	-	-	HYPH
cord-017527-ylng1us2	247	8	characterised	characterise	VBN
cord-017527-ylng1us2	247	9	cell	cell	NN
cord-017527-ylng1us2	247	10	lines	line	NNS
cord-017527-ylng1us2	247	11	or	or	CC
cord-017527-ylng1us2	247	12	controlled	control	VBN
cord-017527-ylng1us2	247	13	cell	cell	NN
cord-017527-ylng1us2	247	14	sources	source	NNS
cord-017527-ylng1us2	247	15	for	for	IN
cord-017527-ylng1us2	247	16	primary	primary	JJ
cord-017527-ylng1us2	247	17	cells	cell	NNS
cord-017527-ylng1us2	247	18	such	such	JJ
cord-017527-ylng1us2	247	19	as	as	IN
cord-017527-ylng1us2	247	20	specified	specify	VBN
cord-017527-ylng1us2	247	21	-	-	HYPH
cord-017527-ylng1us2	247	22	pathogen	pathogen	NN
cord-017527-ylng1us2	247	23	-	-	HYPH
cord-017527-ylng1us2	247	24	free	free	JJ
cord-017527-ylng1us2	247	25	(	(	-LRB-
cord-017527-ylng1us2	247	26	SPF	spf	NN
cord-017527-ylng1us2	247	27	)	)	-RRB-
cord-017527-ylng1us2	247	28	animals	animal	NNS
cord-017527-ylng1us2	247	29	.	.	.
cord-017527-ylng1us2	248	1	If	if	IN
cord-017527-ylng1us2	248	2	no	no	DT
cord-017527-ylng1us2	248	3	well	well	RB
cord-017527-ylng1us2	248	4	-	-	HYPH
cord-017527-ylng1us2	248	5	characterised	characterise	VBN
cord-017527-ylng1us2	248	6	cell	cell	NN
cord-017527-ylng1us2	248	7	lines	line	NNS
cord-017527-ylng1us2	248	8	or	or	CC
cord-017527-ylng1us2	248	9	SPF	SPF	NNP
cord-017527-ylng1us2	248	10	are	be	VBP
cord-017527-ylng1us2	248	11	available	available	JJ
cord-017527-ylng1us2	248	12	,	,	,
cord-017527-ylng1us2	248	13	tests	test	NNS
cord-017527-ylng1us2	248	14	for	for	IN
cord-017527-ylng1us2	248	15	detection	detection	NN
cord-017527-ylng1us2	248	16	of	of	IN
cord-017527-ylng1us2	248	17	likely	likely	JJ
cord-017527-ylng1us2	248	18	contaminating	contaminate	VBG
cord-017527-ylng1us2	248	19	agents	agent	NNS
cord-017527-ylng1us2	248	20	should	should	MD
cord-017527-ylng1us2	248	21	be	be	VB
cord-017527-ylng1us2	248	22	negative	negative	JJ
cord-017527-ylng1us2	248	23	.	.	.
cord-017527-ylng1us2	249	1	Second	second	RB
cord-017527-ylng1us2	249	2	,	,	,
cord-017527-ylng1us2	249	3	whenever	whenever	WRB
cord-017527-ylng1us2	249	4	cell	cell	NN
cord-017527-ylng1us2	249	5	cultures	culture	NNS
cord-017527-ylng1us2	249	6	are	be	VBP
cord-017527-ylng1us2	249	7	manipulated	manipulate	VBN
cord-017527-ylng1us2	249	8	,	,	,
cord-017527-ylng1us2	249	9	media	medium	NNS
cord-017527-ylng1us2	249	10	sources	source	NNS
cord-017527-ylng1us2	249	11	should	should	MD
cord-017527-ylng1us2	249	12	be	be	VB
cord-017527-ylng1us2	249	13	pathogen	pathogen	NN
cord-017527-ylng1us2	249	14	free	free	JJ
cord-017527-ylng1us2	249	15	and	and	CC
cord-017527-ylng1us2	249	16	appropriate	appropriate	JJ
cord-017527-ylng1us2	249	17	containment	containment	NN
cord-017527-ylng1us2	249	18	measures	measure	NNS
cord-017527-ylng1us2	249	19	should	should	MD
cord-017527-ylng1us2	249	20	be	be	VB
cord-017527-ylng1us2	249	21	adopted	adopt	VBN
cord-017527-ylng1us2	249	22	to	to	TO
cord-017527-ylng1us2	249	23	reduce	reduce	VB
cord-017527-ylng1us2	249	24	potential	potential	JJ
cord-017527-ylng1us2	249	25	contaminations	contamination	NNS
cord-017527-ylng1us2	249	26	during	during	IN
cord-017527-ylng1us2	249	27	sampling	sampling	NN
cord-017527-ylng1us2	249	28	or	or	CC
cord-017527-ylng1us2	249	29	subsequent	subsequent	JJ
cord-017527-ylng1us2	249	30	manipulation	manipulation	NN
cord-017527-ylng1us2	249	31	of	of	IN
cord-017527-ylng1us2	249	32	cells	cell	NNS
cord-017527-ylng1us2	249	33	(	(	-LRB-
cord-017527-ylng1us2	249	34	re	re	NN
cord-017527-ylng1us2	249	35	-	-	NN
cord-017527-ylng1us2	249	36	feeding	feeding	JJ
cord-017527-ylng1us2	249	37	and	and	CC
cord-017527-ylng1us2	249	38	washing	washing	NN
cord-017527-ylng1us2	249	39	steps	step	NNS
cord-017527-ylng1us2	249	40	)	)	-RRB-
cord-017527-ylng1us2	249	41	.	.	.
cord-017527-ylng1us2	250	1	As	as	IN
cord-017527-ylng1us2	250	2	the	the	DT
cord-017527-ylng1us2	250	3	history	history	NN
cord-017527-ylng1us2	250	4	of	of	IN
cord-017527-ylng1us2	250	5	a	a	DT
cord-017527-ylng1us2	250	6	cell	cell	NN
cord-017527-ylng1us2	250	7	culture	culture	NN
cord-017527-ylng1us2	250	8	may	may	MD
cord-017527-ylng1us2	250	9	be	be	VB
cord-017527-ylng1us2	250	10	poorly	poorly	RB
cord-017527-ylng1us2	250	11	documented	document	VBN
cord-017527-ylng1us2	250	12	when	when	WRB
cord-017527-ylng1us2	250	13	a	a	DT
cord-017527-ylng1us2	250	14	given	give	VBN
cord-017527-ylng1us2	250	15	cell	cell	NN
cord-017527-ylng1us2	250	16	culture	culture	NN
cord-017527-ylng1us2	250	17	is	be	VBZ
cord-017527-ylng1us2	250	18	manipulated	manipulate	VBN
cord-017527-ylng1us2	250	19	for	for	IN
cord-017527-ylng1us2	250	20	the	the	DT
cord-017527-ylng1us2	250	21	first	first	JJ
cord-017527-ylng1us2	250	22	time	time	NN
cord-017527-ylng1us2	250	23	in	in	IN
cord-017527-ylng1us2	250	24	the	the	DT
cord-017527-ylng1us2	250	25	laboratory	laboratory	NN
cord-017527-ylng1us2	250	26	,	,	,
cord-017527-ylng1us2	250	27	it	-PRON-	PRP
cord-017527-ylng1us2	250	28	often	often	RB
cord-017527-ylng1us2	250	29	remains	remain	VBZ
cord-017527-ylng1us2	250	30	unclear	unclear	JJ
cord-017527-ylng1us2	250	31	whether	whether	IN
cord-017527-ylng1us2	250	32	all	all	DT
cord-017527-ylng1us2	250	33	appropriate	appropriate	JJ
cord-017527-ylng1us2	250	34	measures	measure	NNS
cord-017527-ylng1us2	250	35	have	have	VBP
cord-017527-ylng1us2	250	36	been	be	VBN
cord-017527-ylng1us2	250	37	implemented	implement	VBN
cord-017527-ylng1us2	250	38	regardless	regardless	RB
cord-017527-ylng1us2	250	39	of	of	IN
cord-017527-ylng1us2	250	40	the	the	DT
cord-017527-ylng1us2	250	41	fact	fact	NN
cord-017527-ylng1us2	250	42	that	that	IN
cord-017527-ylng1us2	250	43	it	-PRON-	PRP
cord-017527-ylng1us2	250	44	may	may	MD
cord-017527-ylng1us2	250	45	have	have	VB
cord-017527-ylng1us2	250	46	been	be	VBN
cord-017527-ylng1us2	250	47	manipulated	manipulate	VBN
cord-017527-ylng1us2	250	48	for	for	IN
cord-017527-ylng1us2	250	49	years	year	NNS
cord-017527-ylng1us2	250	50	in	in	IN
cord-017527-ylng1us2	250	51	another	another	DT
cord-017527-ylng1us2	250	52	laboratory	laboratory	NN
cord-017527-ylng1us2	250	53	facility	facility	NN
cord-017527-ylng1us2	250	54	.	.	.
cord-017527-ylng1us2	251	1	In	in	IN
cord-017527-ylng1us2	251	2	this	this	DT
cord-017527-ylng1us2	251	3	case	case	NN
cord-017527-ylng1us2	251	4	,	,	,
cord-017527-ylng1us2	251	5	cell	cell	NN
cord-017527-ylng1us2	251	6	cultures	culture	NNS
cord-017527-ylng1us2	251	7	should	should	MD
cord-017527-ylng1us2	251	8	be	be	VB
cord-017527-ylng1us2	251	9	considered	consider	VBN
cord-017527-ylng1us2	251	10	to	to	TO
cord-017527-ylng1us2	251	11	be	be	VB
cord-017527-ylng1us2	251	12	potentially	potentially	RB
cord-017527-ylng1us2	251	13	infectious	infectious	JJ
cord-017527-ylng1us2	251	14	and	and	CC
cord-017527-ylng1us2	251	15	should	should	MD
cord-017527-ylng1us2	251	16	be	be	VB
cord-017527-ylng1us2	251	17	manipulated	manipulate	VBN
cord-017527-ylng1us2	251	18	in	in	IN
cord-017527-ylng1us2	251	19	a	a	DT
cord-017527-ylng1us2	251	20	class	class	NN
cord-017527-ylng1us2	251	21	II	II	NNP
cord-017527-ylng1us2	251	22	BSC	BSC	NNP
cord-017527-ylng1us2	251	23	.	.	.
cord-017527-ylng1us2	252	1	If	if	IN
cord-017527-ylng1us2	252	2	the	the	DT
cord-017527-ylng1us2	252	3	presence	presence	NN
cord-017527-ylng1us2	252	4	of	of	IN
cord-017527-ylng1us2	252	5	adventitious	adventitious	JJ
cord-017527-ylng1us2	252	6	agents	agent	NNS
cord-017527-ylng1us2	252	7	of	of	IN
cord-017527-ylng1us2	252	8	a	a	DT
cord-017527-ylng1us2	252	9	higher	high	JJR
cord-017527-ylng1us2	252	10	risk	risk	NN
cord-017527-ylng1us2	252	11	group	group	NN
cord-017527-ylng1us2	252	12	is	be	VBZ
cord-017527-ylng1us2	252	13	considered	consider	VBN
cord-017527-ylng1us2	252	14	likely	likely	JJ
cord-017527-ylng1us2	252	15	,	,	,
cord-017527-ylng1us2	252	16	the	the	DT
cord-017527-ylng1us2	252	17	cell	cell	NN
cord-017527-ylng1us2	252	18	line	line	NN
cord-017527-ylng1us2	252	19	should	should	MD
cord-017527-ylng1us2	252	20	be	be	VB
cord-017527-ylng1us2	252	21	handled	handle	VBN
cord-017527-ylng1us2	252	22	under	under	IN
cord-017527-ylng1us2	252	23	the	the	DT
cord-017527-ylng1us2	252	24	appropriate	appropriate	JJ
cord-017527-ylng1us2	252	25	containment	containment	NN
cord-017527-ylng1us2	252	26	level	level	NN
cord-017527-ylng1us2	252	27	until	until	IN
cord-017527-ylng1us2	252	28	tests	test	NNS
cord-017527-ylng1us2	252	29	have	have	VBP
cord-017527-ylng1us2	252	30	proven	prove	VBN
cord-017527-ylng1us2	252	31	the	the	DT
cord-017527-ylng1us2	252	32	absence	absence	NN
cord-017527-ylng1us2	252	33	of	of	IN
cord-017527-ylng1us2	252	34	such	such	JJ
cord-017527-ylng1us2	252	35	organisms	organism	NNS
cord-017527-ylng1us2	252	36	.	.	.
cord-017527-ylng1us2	253	1	Good	good	JJ
cord-017527-ylng1us2	253	2	documentation	documentation	NN
cord-017527-ylng1us2	253	3	of	of	IN
cord-017527-ylng1us2	253	4	the	the	DT
cord-017527-ylng1us2	253	5	history	history	NN
cord-017527-ylng1us2	253	6	of	of	IN
cord-017527-ylng1us2	253	7	cell	cell	NN
cord-017527-ylng1us2	253	8	cultivation	cultivation	NN
cord-017527-ylng1us2	253	9	is	be	VBZ
cord-017527-ylng1us2	253	10	mandatory	mandatory	JJ
cord-017527-ylng1us2	253	11	.	.	.
cord-017527-ylng1us2	254	1	The	the	DT
cord-017527-ylng1us2	254	2	extent	extent	NN
cord-017527-ylng1us2	254	3	to	to	TO
cord-017527-ylng1us2	254	4	which	which	WDT
cord-017527-ylng1us2	254	5	cell	cell	NN
cord-017527-ylng1us2	254	6	cultures	culture	NNS
cord-017527-ylng1us2	254	7	should	should	MD
cord-017527-ylng1us2	254	8	be	be	VB
cord-017527-ylng1us2	254	9	controlled	control	VBN
cord-017527-ylng1us2	254	10	on	on	IN
cord-017527-ylng1us2	254	11	the	the	DT
cord-017527-ylng1us2	254	12	likelihood	likelihood	NN
cord-017527-ylng1us2	254	13	of	of	IN
cord-017527-ylng1us2	254	14	contaminants	contaminant	NNS
cord-017527-ylng1us2	254	15	strongly	strongly	RB
cord-017527-ylng1us2	254	16	depends	depend	VBZ
cord-017527-ylng1us2	254	17	on	on	IN
cord-017527-ylng1us2	254	18	the	the	DT
cord-017527-ylng1us2	254	19	nature	nature	NN
cord-017527-ylng1us2	254	20	of	of	IN
cord-017527-ylng1us2	254	21	activity	activity	NN
cord-017527-ylng1us2	254	22	.	.	.
cord-017527-ylng1us2	255	1	For	for	IN
cord-017527-ylng1us2	255	2	example	example	NN
cord-017527-ylng1us2	255	3	,	,	,
cord-017527-ylng1us2	255	4	guidelines	guideline	NNS
cord-017527-ylng1us2	255	5	have	have	VBP
cord-017527-ylng1us2	255	6	been	be	VBN
cord-017527-ylng1us2	255	7	issued	issue	VBN
cord-017527-ylng1us2	255	8	aiming	aim	VBG
cord-017527-ylng1us2	255	9	at	at	IN
cord-017527-ylng1us2	255	10	minimising	minimise	VBG
cord-017527-ylng1us2	255	11	any	any	DT
cord-017527-ylng1us2	255	12	potential	potential	JJ
cord-017527-ylng1us2	255	13	risk	risk	NN
cord-017527-ylng1us2	255	14	for	for	IN
cord-017527-ylng1us2	255	15	transmission	transmission	NN
cord-017527-ylng1us2	255	16	of	of	IN
cord-017527-ylng1us2	255	17	infectious	infectious	JJ
cord-017527-ylng1us2	255	18	agents	agent	NNS
cord-017527-ylng1us2	255	19	with	with	IN
cord-017527-ylng1us2	255	20	respect	respect	NN
cord-017527-ylng1us2	255	21	the	the	DT
cord-017527-ylng1us2	255	22	use	use	NN
cord-017527-ylng1us2	255	23	of	of	IN
cord-017527-ylng1us2	255	24	animal	animal	NN
cord-017527-ylng1us2	255	25	cell	cell	NN
cord-017527-ylng1us2	255	26	cultures	culture	NNS
cord-017527-ylng1us2	255	27	for	for	IN
cord-017527-ylng1us2	255	28	industrial	industrial	JJ
cord-017527-ylng1us2	255	29	production	production	NN
cord-017527-ylng1us2	255	30	of	of	IN
cord-017527-ylng1us2	255	31	biopharmaceuticals	biopharmaceutical	NNS
cord-017527-ylng1us2	255	32	(	(	-LRB-
cord-017527-ylng1us2	255	33	European	European	NNP
cord-017527-ylng1us2	255	34	Medicines	Medicines	NNPS
cord-017527-ylng1us2	255	35	Agency	Agency	NNP
cord-017527-ylng1us2	255	36	;	;	:
cord-017527-ylng1us2	255	37	Food	Food	NNP
cord-017527-ylng1us2	255	38	and	and	CC
cord-017527-ylng1us2	255	39	Drug	Drug	NNP
cord-017527-ylng1us2	255	40	Administration	Administration	NNP
cord-017527-ylng1us2	255	41	;	;	:
cord-017527-ylng1us2	255	42	ICH	ICH	NNP
cord-017527-ylng1us2	255	43	1997	1997	CD
cord-017527-ylng1us2	255	44	;	;	:
cord-017527-ylng1us2	255	45	World	World	NNP
cord-017527-ylng1us2	255	46	Health	Health	NNP
cord-017527-ylng1us2	255	47	Organization	Organization	NNP
cord-017527-ylng1us2	255	48	1998	1998	CD
cord-017527-ylng1us2	255	49	)	)	-RRB-
cord-017527-ylng1us2	255	50	.	.	.
cord-017527-ylng1us2	256	1	Hardly	hardly	RB
cord-017527-ylng1us2	256	2	any	any	DT
cord-017527-ylng1us2	256	3	guidance	guidance	NN
cord-017527-ylng1us2	256	4	has	have	VBZ
cord-017527-ylng1us2	256	5	been	be	VBN
cord-017527-ylng1us2	256	6	provided	provide	VBN
cord-017527-ylng1us2	256	7	for	for	IN
cord-017527-ylng1us2	256	8	the	the	DT
cord-017527-ylng1us2	256	9	extent	extent	NN
cord-017527-ylng1us2	256	10	of	of	IN
cord-017527-ylng1us2	256	11	detecting	detect	VBG
cord-017527-ylng1us2	256	12	possible	possible	JJ
cord-017527-ylng1us2	256	13	contaminants	contaminant	NNS
cord-017527-ylng1us2	256	14	in	in	IN
cord-017527-ylng1us2	256	15	case	case	NN
cord-017527-ylng1us2	256	16	animal	animal	NN
cord-017527-ylng1us2	256	17	cell	cell	NN
cord-017527-ylng1us2	256	18	cultures	culture	NNS
cord-017527-ylng1us2	256	19	are	be	VBP
cord-017527-ylng1us2	256	20	used	use	VBN
cord-017527-ylng1us2	256	21	for	for	IN
cord-017527-ylng1us2	256	22	in	in	FW
cord-017527-ylng1us2	256	23	vitro	vitro	FW
cord-017527-ylng1us2	256	24	research	research	NN
cord-017527-ylng1us2	256	25	or	or	CC
cord-017527-ylng1us2	256	26	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	256	27	activities	activity	NNS
cord-017527-ylng1us2	256	28	,	,	,
cord-017527-ylng1us2	256	29	or	or	CC
cord-017527-ylng1us2	256	30	for	for	IN
cord-017527-ylng1us2	256	31	purposes	purpose	NNS
cord-017527-ylng1us2	256	32	other	other	JJ
cord-017527-ylng1us2	256	33	than	than	IN
cord-017527-ylng1us2	256	34	therapeutics	therapeutic	NNS
cord-017527-ylng1us2	256	35	or	or	CC
cord-017527-ylng1us2	256	36	production	production	NN
cord-017527-ylng1us2	256	37	of	of	IN
cord-017527-ylng1us2	256	38	biopharmaceuticals	biopharmaceutical	NNS
cord-017527-ylng1us2	256	39	.	.	.
cord-017527-ylng1us2	257	1	The	the	DT
cord-017527-ylng1us2	257	2	choice	choice	NN
cord-017527-ylng1us2	257	3	of	of	IN
cord-017527-ylng1us2	257	4	the	the	DT
cord-017527-ylng1us2	257	5	detection	detection	NN
cord-017527-ylng1us2	257	6	technique	technique	NN
cord-017527-ylng1us2	257	7	depends	depend	VBZ
cord-017527-ylng1us2	257	8	on	on	IN
cord-017527-ylng1us2	257	9	the	the	DT
cord-017527-ylng1us2	257	10	contaminating	contaminate	VBG
cord-017527-ylng1us2	257	11	pathogen	pathogen	NN
cord-017527-ylng1us2	257	12	and	and	CC
cord-017527-ylng1us2	257	13	often	often	RB
cord-017527-ylng1us2	257	14	a	a	DT
cord-017527-ylng1us2	257	15	combination	combination	NN
cord-017527-ylng1us2	257	16	of	of	IN
cord-017527-ylng1us2	257	17	methods	method	NNS
cord-017527-ylng1us2	257	18	is	be	VBZ
cord-017527-ylng1us2	257	19	recommended	recommend	VBN
cord-017527-ylng1us2	257	20	for	for	IN
cord-017527-ylng1us2	257	21	important	important	JJ
cord-017527-ylng1us2	257	22	samples	sample	NNS
cord-017527-ylng1us2	257	23	such	such	JJ
cord-017527-ylng1us2	257	24	as	as	IN
cord-017527-ylng1us2	257	25	master	master	NN
cord-017527-ylng1us2	257	26	cell	cell	NN
cord-017527-ylng1us2	257	27	banks	bank	NNS
cord-017527-ylng1us2	257	28	.	.	.
cord-017527-ylng1us2	258	1	The	the	DT
cord-017527-ylng1us2	258	2	implementation	implementation	NN
cord-017527-ylng1us2	258	3	of	of	IN
cord-017527-ylng1us2	258	4	BSL2	BSL2	NNP
cord-017527-ylng1us2	258	5	measures	measure	NNS
cord-017527-ylng1us2	258	6	is	be	VBZ
cord-017527-ylng1us2	258	7	adequate	adequate	JJ
cord-017527-ylng1us2	258	8	for	for	IN
cord-017527-ylng1us2	258	9	most	most	JJS
cord-017527-ylng1us2	258	10	of	of	IN
cord-017527-ylng1us2	258	11	the	the	DT
cord-017527-ylng1us2	258	12	work	work	NN
cord-017527-ylng1us2	258	13	carried	carry	VBN
cord-017527-ylng1us2	258	14	out	out	RP
cord-017527-ylng1us2	258	15	with	with	IN
cord-017527-ylng1us2	258	16	cell	cell	NN
cord-017527-ylng1us2	258	17	cultures	culture	NNS
cord-017527-ylng1us2	258	18	from	from	IN
cord-017527-ylng1us2	258	19	human	human	JJ
cord-017527-ylng1us2	258	20	or	or	CC
cord-017527-ylng1us2	258	21	primate	primate	JJ
cord-017527-ylng1us2	258	22	origin	origin	NN
cord-017527-ylng1us2	258	23	.	.	.
cord-017527-ylng1us2	259	1	BSL1	bsl1	JJ
cord-017527-ylng1us2	259	2	measures	measure	NNS
cord-017527-ylng1us2	259	3	may	may	MD
cord-017527-ylng1us2	259	4	be	be	VB
cord-017527-ylng1us2	259	5	considered	consider	VBN
cord-017527-ylng1us2	259	6	provided	provide	VBN
cord-017527-ylng1us2	259	7	that	that	IN
cord-017527-ylng1us2	259	8	all	all	DT
cord-017527-ylng1us2	259	9	manipulations	manipulation	NNS
cord-017527-ylng1us2	259	10	occur	occur	VBP
cord-017527-ylng1us2	259	11	in	in	IN
cord-017527-ylng1us2	259	12	a	a	DT
cord-017527-ylng1us2	259	13	class	class	NN
cord-017527-ylng1us2	259	14	II	II	NNP
cord-017527-ylng1us2	259	15	BSC	BSC	NNP
cord-017527-ylng1us2	259	16	and	and	CC
cord-017527-ylng1us2	259	17	the	the	DT
cord-017527-ylng1us2	259	18	cell	cell	NN
cord-017527-ylng1us2	259	19	culture	culture	NN
cord-017527-ylng1us2	259	20	is	be	VBZ
cord-017527-ylng1us2	259	21	a	a	DT
cord-017527-ylng1us2	259	22	well	well	RB
cord-017527-ylng1us2	259	23	-	-	HYPH
cord-017527-ylng1us2	259	24	characterised	characterise	VBN
cord-017527-ylng1us2	259	25	and	and	CC
cord-017527-ylng1us2	259	26	certified	certified	JJ
cord-017527-ylng1us2	259	27	cell	cell	NN
cord-017527-ylng1us2	259	28	line	line	NN
cord-017527-ylng1us2	259	29	that	that	WDT
cord-017527-ylng1us2	259	30	presents	present	VBZ
cord-017527-ylng1us2	259	31	no	no	DT
cord-017527-ylng1us2	259	32	increased	increase	VBN
cord-017527-ylng1us2	259	33	risk	risk	NN
cord-017527-ylng1us2	259	34	resulting	result	VBG
cord-017527-ylng1us2	259	35	from	from	IN
cord-017527-ylng1us2	259	36	genetic	genetic	JJ
cord-017527-ylng1us2	259	37	modification	modification	NN
cord-017527-ylng1us2	259	38	or	or	CC
cord-017527-ylng1us2	259	39	contaminating	contaminate	VBG
cord-017527-ylng1us2	259	40	pathogen	pathogen	NN
cord-017527-ylng1us2	259	41	.	.	.
cord-017527-ylng1us2	260	1	The	the	DT
cord-017527-ylng1us2	260	2	contained	contain	VBN
cord-017527-ylng1us2	260	3	use	use	NN
cord-017527-ylng1us2	260	4	To	to	TO
cord-017527-ylng1us2	260	5	be	be	VB
cord-017527-ylng1us2	260	6	in	in	IN
cord-017527-ylng1us2	260	7	compliance	compliance	NN
cord-017527-ylng1us2	260	8	with	with	IN
cord-017527-ylng1us2	260	9	good	good	JJ
cord-017527-ylng1us2	260	10	cell	cell	NN
cord-017527-ylng1us2	260	11	culture	culture	NN
cord-017527-ylng1us2	260	12	practice	practice	NN
cord-017527-ylng1us2	260	13	(	(	-LRB-
cord-017527-ylng1us2	260	14	GCCP	GCCP	NNP
cord-017527-ylng1us2	260	15	)	)	-RRB-
cord-017527-ylng1us2	260	16	,	,	,
cord-017527-ylng1us2	260	17	especially	especially	RB
cord-017527-ylng1us2	260	18	in	in	IN
cord-017527-ylng1us2	260	19	industrial	industrial	JJ
cord-017527-ylng1us2	260	20	settings	setting	NNS
cord-017527-ylng1us2	260	21	for	for	IN
cord-017527-ylng1us2	260	22	vaccine	vaccine	NN
cord-017527-ylng1us2	260	23	production	production	NN
cord-017527-ylng1us2	260	24	.	.	.
cord-017527-ylng1us2	261	1	To	to	TO
cord-017527-ylng1us2	261	2	avoid	avoid	VB
cord-017527-ylng1us2	261	3	opening	opening	NN
cord-017527-ylng1us2	261	4	of	of	IN
cord-017527-ylng1us2	261	5	culture	culture	NN
cord-017527-ylng1us2	261	6	vessels	vessel	NNS
cord-017527-ylng1us2	261	7	or	or	CC
cord-017527-ylng1us2	261	8	contact	contact	NN
cord-017527-ylng1us2	261	9	with	with	IN
cord-017527-ylng1us2	261	10	culture	culture	NN
cord-017527-ylng1us2	261	11	fluid	fluid	NN
cord-017527-ylng1us2	261	12	through	through	IN
cord-017527-ylng1us2	261	13	a	a	DT
cord-017527-ylng1us2	261	14	defective	defective	JJ
cord-017527-ylng1us2	261	15	culture	culture	NN
cord-017527-ylng1us2	261	16	vessel	vessel	NN
cord-017527-ylng1us2	261	17	,	,	,
cord-017527-ylng1us2	261	18	stopper	stopper	NN
cord-017527-ylng1us2	261	19	or	or	CC
cord-017527-ylng1us2	261	20	poor	poor	JJ
cord-017527-ylng1us2	261	21	technique	technique	NN
cord-017527-ylng1us2	261	22	because	because	IN
cord-017527-ylng1us2	261	23	of	of	IN
cord-017527-ylng1us2	261	24	the	the	DT
cord-017527-ylng1us2	261	25	ever	ever	RB
cord-017527-ylng1us2	261	26	present	present	JJ
cord-017527-ylng1us2	261	27	likelihood	likelihood	NN
cord-017527-ylng1us2	261	28	of	of	IN
cord-017527-ylng1us2	261	29	contamination	contamination	NN
cord-017527-ylng1us2	261	30	with	with	IN
cord-017527-ylng1us2	261	31	airborne	airborne	JJ
cord-017527-ylng1us2	261	32	pathogens	pathogen	NNS
cord-017527-ylng1us2	261	33	.	.	.
cord-017527-ylng1us2	262	1	To	to	TO
cord-017527-ylng1us2	262	2	treat	treat	VB
cord-017527-ylng1us2	262	3	each	each	DT
cord-017527-ylng1us2	262	4	new	new	JJ
cord-017527-ylng1us2	262	5	culture	culture	NN
cord-017527-ylng1us2	262	6	that	that	WDT
cord-017527-ylng1us2	262	7	is	be	VBZ
cord-017527-ylng1us2	262	8	manipulated	manipulate	VBN
cord-017527-ylng1us2	262	9	for	for	IN
cord-017527-ylng1us2	262	10	the	the	DT
cord-017527-ylng1us2	262	11	first	first	JJ
cord-017527-ylng1us2	262	12	time	time	NN
cord-017527-ylng1us2	262	13	in	in	IN
cord-017527-ylng1us2	262	14	the	the	DT
cord-017527-ylng1us2	262	15	laboratory	laboratory	NN
cord-017527-ylng1us2	262	16	facility	facility	NN
cord-017527-ylng1us2	262	17	as	as	IN
cord-017527-ylng1us2	262	18	potentially	potentially	RB
cord-017527-ylng1us2	262	19	infectious	infectious	JJ
cord-017527-ylng1us2	262	20	.	.	.
cord-017527-ylng1us2	263	1	To	to	TO
cord-017527-ylng1us2	263	2	clean	clean	VB
cord-017527-ylng1us2	263	3	up	up	RP
cord-017527-ylng1us2	263	4	any	any	DT
cord-017527-ylng1us2	263	5	culture	culture	NN
cord-017527-ylng1us2	263	6	fluid	fluid	NN
cord-017527-ylng1us2	263	7	spills	spill	VBZ
cord-017527-ylng1us2	263	8	immediately	immediately	RB
cord-017527-ylng1us2	263	9	with	with	IN
cord-017527-ylng1us2	263	10	an	an	DT
cord-017527-ylng1us2	263	11	appropriated	appropriate	VBN
cord-017527-ylng1us2	263	12	and	and	CC
cord-017527-ylng1us2	263	13	validated	validate	VBN
cord-017527-ylng1us2	263	14	disinfection	disinfection	NN
cord-017527-ylng1us2	263	15	protocol	protocol	NN
cord-017527-ylng1us2	263	16	.	.	.
cord-017527-ylng1us2	264	1	To	to	TO
cord-017527-ylng1us2	264	2	work	work	VB
cord-017527-ylng1us2	264	3	with	with	IN
cord-017527-ylng1us2	264	4	one	one	CD
cord-017527-ylng1us2	264	5	cell	cell	NN
cord-017527-ylng1us2	264	6	line	line	NN
cord-017527-ylng1us2	264	7	at	at	IN
cord-017527-ylng1us2	264	8	a	a	DT
cord-017527-ylng1us2	264	9	time	time	NN
cord-017527-ylng1us2	264	10	and	and	CC
cord-017527-ylng1us2	264	11	disinfect	disinfect	VB
cord-017527-ylng1us2	264	12	the	the	DT
cord-017527-ylng1us2	264	13	work	work	NN
cord-017527-ylng1us2	264	14	surfaces	surface	NNS
cord-017527-ylng1us2	264	15	between	between	IN
cord-017527-ylng1us2	264	16	two	two	CD
cord-017527-ylng1us2	264	17	operations	operation	NNS
cord-017527-ylng1us2	264	18	involving	involve	VBG
cord-017527-ylng1us2	264	19	cell	cell	NN
cord-017527-ylng1us2	264	20	lines	line	NNS
cord-017527-ylng1us2	264	21	.	.	.
cord-017527-ylng1us2	265	1	To	to	IN
cord-017527-ylng1us2	265	2	aliquot	aliquot	JJ
cord-017527-ylng1us2	265	3	growth	growth	NN
cord-017527-ylng1us2	265	4	medium	medium	NN
cord-017527-ylng1us2	265	5	and	and	CC
cord-017527-ylng1us2	265	6	other	other	JJ
cord-017527-ylng1us2	265	7	substrates	substrate	NNS
cord-017527-ylng1us2	265	8	so	so	IN
cord-017527-ylng1us2	265	9	that	that	IN
cord-017527-ylng1us2	265	10	the	the	DT
cord-017527-ylng1us2	265	11	same	same	JJ
cord-017527-ylng1us2	265	12	vessel	vessel	NN
cord-017527-ylng1us2	265	13	is	be	VBZ
cord-017527-ylng1us2	265	14	not	not	RB
cord-017527-ylng1us2	265	15	used	use	VBN
cord-017527-ylng1us2	265	16	for	for	IN
cord-017527-ylng1us2	265	17	more	more	JJR
cord-017527-ylng1us2	265	18	than	than	IN
cord-017527-ylng1us2	265	19	one	one	CD
cord-017527-ylng1us2	265	20	cell	cell	NN
cord-017527-ylng1us2	265	21	line	line	NN
cord-017527-ylng1us2	265	22	.	.	.
cord-017527-ylng1us2	266	1	To	to	TO
cord-017527-ylng1us2	266	2	mitigate	mitigate	VB
cord-017527-ylng1us2	266	3	cross	cross	NN
cord-017527-ylng1us2	266	4	-	-	NN
cord-017527-ylng1us2	266	5	contamination	contamination	NN
cord-017527-ylng1us2	266	6	by	by	IN
cord-017527-ylng1us2	266	7	avoiding	avoid	VBG
cord-017527-ylng1us2	266	8	pouring	pour	VBG
cord-017527-ylng1us2	266	9	actions	action	NNS
cord-017527-ylng1us2	266	10	.	.	.
cord-017527-ylng1us2	267	1	To	to	TO
cord-017527-ylng1us2	267	2	proceed	proceed	VB
cord-017527-ylng1us2	267	3	to	to	IN
cord-017527-ylng1us2	267	4	the	the	DT
cord-017527-ylng1us2	267	5	use	use	NN
cord-017527-ylng1us2	267	6	of	of	IN
cord-017527-ylng1us2	267	7	the	the	DT
cord-017527-ylng1us2	267	8	biosafety	biosafety	NN
cord-017527-ylng1us2	267	9	cabinet	cabinet	NN
cord-017527-ylng1us2	267	10	(	(	-LRB-
cord-017527-ylng1us2	267	11	BSC	BSC	NNP
cord-017527-ylng1us2	267	12	)	)	-RRB-
cord-017527-ylng1us2	267	13	by	by	IN
cord-017527-ylng1us2	267	14	adequately	adequately	RB
cord-017527-ylng1us2	267	15	trained	train	VBN
cord-017527-ylng1us2	267	16	staff	staff	NN
cord-017527-ylng1us2	267	17	,	,	,
cord-017527-ylng1us2	267	18	t.i	t.i	NNP
cord-017527-ylng1us2	267	19	.	.	NNP
cord-017527-ylng1us2	267	20	turn	turn	VB
cord-017527-ylng1us2	267	21	on	on	RP
cord-017527-ylng1us2	267	22	for	for	IN
cord-017527-ylng1us2	267	23	a	a	DT
cord-017527-ylng1us2	267	24	period	period	NN
cord-017527-ylng1us2	267	25	before	before	IN
cord-017527-ylng1us2	267	26	and	and	CC
cord-017527-ylng1us2	267	27	after	after	IN
cord-017527-ylng1us2	267	28	use	use	NN
cord-017527-ylng1us2	267	29	,	,	,
cord-017527-ylng1us2	267	30	thoroughly	thoroughly	RB
cord-017527-ylng1us2	267	31	disinfect	disinfect	VB
cord-017527-ylng1us2	267	32	BSC	BSC	NNP
cord-017527-ylng1us2	267	33	surfaces	surface	NNS
cord-017527-ylng1us2	267	34	after	after	IN
cord-017527-ylng1us2	267	35	each	each	DT
cord-017527-ylng1us2	267	36	work	work	NN
cord-017527-ylng1us2	267	37	session	session	NN
cord-017527-ylng1us2	267	38	and	and	CC
cord-017527-ylng1us2	267	39	do	do	VBP
cord-017527-ylng1us2	267	40	not	not	RB
cord-017527-ylng1us2	267	41	clutter	clutter	VB
cord-017527-ylng1us2	267	42	the	the	DT
cord-017527-ylng1us2	267	43	BSC	BSC	NNP
cord-017527-ylng1us2	267	44	with	with	IN
cord-017527-ylng1us2	267	45	unnecessary	unnecessary	JJ
cord-017527-ylng1us2	267	46	materials	material	NNS
cord-017527-ylng1us2	267	47	.	.	.
cord-017527-ylng1us2	268	1	To	to	TO
cord-017527-ylng1us2	268	2	restrict	restrict	VB
cord-017527-ylng1us2	268	3	the	the	DT
cord-017527-ylng1us2	268	4	use	use	NN
cord-017527-ylng1us2	268	5	of	of	IN
cord-017527-ylng1us2	268	6	antibiotics	antibiotic	NNS
cord-017527-ylng1us2	268	7	in	in	IN
cord-017527-ylng1us2	268	8	growth	growth	NN
cord-017527-ylng1us2	268	9	media	medium	NNS
cord-017527-ylng1us2	268	10	.	.	.
cord-017527-ylng1us2	269	1	To	to	TO
cord-017527-ylng1us2	269	2	quarantine	quarantine	VB
cord-017527-ylng1us2	269	3	new	new	JJ
cord-017527-ylng1us2	269	4	cell	cell	NN
cord-017527-ylng1us2	269	5	cultures	culture	NNS
cord-017527-ylng1us2	269	6	to	to	IN
cord-017527-ylng1us2	269	7	a	a	DT
cord-017527-ylng1us2	269	8	dedicated	dedicated	JJ
cord-017527-ylng1us2	269	9	BSC	BSC	NNP
cord-017527-ylng1us2	269	10	or	or	CC
cord-017527-ylng1us2	269	11	separate	separate	JJ
cord-017527-ylng1us2	269	12	laboratory	laboratory	NN
cord-017527-ylng1us2	269	13	until	until	IN
cord-017527-ylng1us2	269	14	the	the	DT
cord-017527-ylng1us2	269	15	culture	culture	NN
cord-017527-ylng1us2	269	16	has	have	VBZ
cord-017527-ylng1us2	269	17	been	be	VBN
cord-017527-ylng1us2	269	18	shown	show	VBN
cord-017527-ylng1us2	269	19	negative	negative	JJ
cord-017527-ylng1us2	269	20	in	in	IN
cord-017527-ylng1us2	269	21	appropriate	appropriate	JJ
cord-017527-ylng1us2	269	22	tests	test	NNS
cord-017527-ylng1us2	269	23	.	.	.
cord-017527-ylng1us2	270	1	To	to	TO
cord-017527-ylng1us2	270	2	carry	carry	VB
cord-017527-ylng1us2	270	3	out	out	RP
cord-017527-ylng1us2	270	4	a	a	DT
cord-017527-ylng1us2	270	5	quality	quality	NN
cord-017527-ylng1us2	270	6	control	control	NN
cord-017527-ylng1us2	270	7	of	of	IN
cord-017527-ylng1us2	270	8	cells	cell	NNS
cord-017527-ylng1us2	270	9	demonstrating	demonstrate	VBG
cord-017527-ylng1us2	270	10	the	the	DT
cord-017527-ylng1us2	270	11	absence	absence	NN
cord-017527-ylng1us2	270	12	of	of	IN
cord-017527-ylng1us2	270	13	likely	likely	JJ
cord-017527-ylng1us2	270	14	contaminating	contaminate	VBG
cord-017527-ylng1us2	270	15	pathogens	pathogen	NNS
cord-017527-ylng1us2	270	16	on	on	IN
cord-017527-ylng1us2	270	17	a	a	DT
cord-017527-ylng1us2	270	18	regular	regular	JJ
cord-017527-ylng1us2	270	19	basis	basis	NN
cord-017527-ylng1us2	270	20	or	or	CC
cord-017527-ylng1us2	270	21	whenever	whenever	WRB
cord-017527-ylng1us2	270	22	necessary	necessary	JJ
cord-017527-ylng1us2	270	23	.	.	.
cord-017527-ylng1us2	271	1	To	to	TO
cord-017527-ylng1us2	271	2	operate	operate	VB
cord-017527-ylng1us2	271	3	cell	cell	NN
cord-017527-ylng1us2	271	4	cultures	culture	NNS
cord-017527-ylng1us2	271	5	from	from	IN
cord-017527-ylng1us2	271	6	undefined	undefined	JJ
cord-017527-ylng1us2	271	7	sources	source	NNS
cord-017527-ylng1us2	271	8	as	as	IN
cord-017527-ylng1us2	271	9	risk	risk	NN
cord-017527-ylng1us2	271	10	group	group	NN
cord-017527-ylng1us2	271	11	/	/	SYM
cord-017527-ylng1us2	271	12	class	class	NN
cord-017527-ylng1us2	271	13	of	of	IN
cord-017527-ylng1us2	271	14	risk	risk	NN
cord-017527-ylng1us2	271	15	2	2	CD
cord-017527-ylng1us2	271	16	organism	organism	NN
cord-017527-ylng1us2	271	17	.	.	.
cord-017527-ylng1us2	272	1	If	if	IN
cord-017527-ylng1us2	272	2	the	the	DT
cord-017527-ylng1us2	272	3	presence	presence	NN
cord-017527-ylng1us2	272	4	of	of	IN
cord-017527-ylng1us2	272	5	adventitious	adventitious	JJ
cord-017527-ylng1us2	272	6	agents	agent	NNS
cord-017527-ylng1us2	272	7	of	of	IN
cord-017527-ylng1us2	272	8	higher	high	JJR
cord-017527-ylng1us2	272	9	risk	risk	NN
cord-017527-ylng1us2	272	10	class	class	NN
cord-017527-ylng1us2	272	11	is	be	VBZ
cord-017527-ylng1us2	272	12	expected	expect	VBN
cord-017527-ylng1us2	272	13	,	,	,
cord-017527-ylng1us2	272	14	the	the	DT
cord-017527-ylng1us2	272	15	cell	cell	NN
cord-017527-ylng1us2	272	16	line	line	NN
cord-017527-ylng1us2	272	17	should	should	MD
cord-017527-ylng1us2	272	18	be	be	VB
cord-017527-ylng1us2	272	19	handled	handle	VBN
cord-017527-ylng1us2	272	20	under	under	IN
cord-017527-ylng1us2	272	21	appropriate	appropriate	JJ
cord-017527-ylng1us2	272	22	containment	containment	NN
cord-017527-ylng1us2	272	23	level	level	NN
cord-017527-ylng1us2	272	24	until	until	IN
cord-017527-ylng1us2	272	25	tests	test	NNS
cord-017527-ylng1us2	272	26	have	have	VBP
cord-017527-ylng1us2	272	27	proven	prove	VBN
cord-017527-ylng1us2	272	28	safety	safety	NN
cord-017527-ylng1us2	272	29	.	.	.
cord-017527-ylng1us2	273	1	Adapted	adapt	VBN
cord-017527-ylng1us2	273	2	from	from	IN
cord-017527-ylng1us2	273	3	Pauwels	Pauwels	NNP
cord-017527-ylng1us2	273	4	et	et	NNP
cord-017527-ylng1us2	273	5	al	al	NNP
cord-017527-ylng1us2	273	6	.	.	.
cord-017527-ylng1us2	274	1	(	(	-LRB-
cord-017527-ylng1us2	274	2	2007	2007	CD
cord-017527-ylng1us2	274	3	)	)	-RRB-
cord-017527-ylng1us2	274	4	in	in	IN
cord-017527-ylng1us2	274	5	a	a	DT
cord-017527-ylng1us2	274	6	BSL1	BSL1	NNP
cord-017527-ylng1us2	274	7	of	of	IN
cord-017527-ylng1us2	274	8	viral	viral	JJ
cord-017527-ylng1us2	274	9	infected	infected	JJ
cord-017527-ylng1us2	274	10	cells	cell	NNS
cord-017527-ylng1us2	274	11	could	could	MD
cord-017527-ylng1us2	274	12	be	be	VB
cord-017527-ylng1us2	274	13	envisaged	envisage	VBN
cord-017527-ylng1us2	274	14	if	if	IN
cord-017527-ylng1us2	274	15	no	no	DT
cord-017527-ylng1us2	274	16	viral	viral	JJ
cord-017527-ylng1us2	274	17	particles	particle	NNS
cord-017527-ylng1us2	274	18	are	be	VBP
cord-017527-ylng1us2	274	19	detectable	detectable	JJ
cord-017527-ylng1us2	274	20	in	in	IN
cord-017527-ylng1us2	274	21	the	the	DT
cord-017527-ylng1us2	274	22	supernatant	supernatant	NN
cord-017527-ylng1us2	274	23	of	of	IN
cord-017527-ylng1us2	274	24	the	the	DT
cord-017527-ylng1us2	274	25	infected	infected	JJ
cord-017527-ylng1us2	274	26	cells	cell	NNS
cord-017527-ylng1us2	274	27	.	.	.
cord-017527-ylng1us2	275	1	However	however	RB
cord-017527-ylng1us2	275	2	,	,	,
cord-017527-ylng1us2	275	3	it	-PRON-	PRP
cord-017527-ylng1us2	275	4	should	should	MD
cord-017527-ylng1us2	275	5	be	be	VB
cord-017527-ylng1us2	275	6	emphasized	emphasize	VBN
cord-017527-ylng1us2	275	7	that	that	IN
cord-017527-ylng1us2	275	8	procedures	procedure	NNS
cord-017527-ylng1us2	275	9	for	for	IN
cord-017527-ylng1us2	275	10	viral	viral	JJ
cord-017527-ylng1us2	275	11	clearance	clearance	NN
cord-017527-ylng1us2	275	12	are	be	VBP
cord-017527-ylng1us2	275	13	virus	virus	NN
cord-017527-ylng1us2	275	14	-	-	HYPH
cord-017527-ylng1us2	275	15	host	host	NN
cord-017527-ylng1us2	275	16	specific	specific	JJ
cord-017527-ylng1us2	275	17	and	and	CC
cord-017527-ylng1us2	275	18	that	that	IN
cord-017527-ylng1us2	275	19	variables	variable	NNS
cord-017527-ylng1us2	275	20	such	such	JJ
cord-017527-ylng1us2	275	21	as	as	IN
cord-017527-ylng1us2	275	22	vector	vector	NN
cord-017527-ylng1us2	275	23	titre	titre	NN
cord-017527-ylng1us2	275	24	and	and	CC
cord-017527-ylng1us2	275	25	the	the	DT
cord-017527-ylng1us2	275	26	infection	infection	NN
cord-017527-ylng1us2	275	27	protocol	protocol	NN
cord-017527-ylng1us2	275	28	can	can	MD
cord-017527-ylng1us2	275	29	influence	influence	VB
cord-017527-ylng1us2	275	30	the	the	DT
cord-017527-ylng1us2	275	31	degree	degree	NN
cord-017527-ylng1us2	275	32	and	and	CC
cord-017527-ylng1us2	275	33	rate	rate	NN
cord-017527-ylng1us2	275	34	of	of	IN
cord-017527-ylng1us2	275	35	clearance	clearance	NN
cord-017527-ylng1us2	276	1	(	(	-LRB-
cord-017527-ylng1us2	276	2	Bagutti	Bagutti	NNP
cord-017527-ylng1us2	276	3	et	et	NNP
cord-017527-ylng1us2	276	4	al	al	NNP
cord-017527-ylng1us2	276	5	.	.	NNP
cord-017527-ylng1us2	276	6	2012	2012	CD
cord-017527-ylng1us2	276	7	)	)	-RRB-
cord-017527-ylng1us2	276	8	.	.	.
cord-017527-ylng1us2	277	1	Since	since	IN
cord-017527-ylng1us2	277	2	the	the	DT
cord-017527-ylng1us2	277	3	implementation	implementation	NN
cord-017527-ylng1us2	277	4	of	of	IN
cord-017527-ylng1us2	277	5	good	good	JJ
cord-017527-ylng1us2	277	6	laboratory	laboratory	NN
cord-017527-ylng1us2	277	7	practices	practice	NNS
cord-017527-ylng1us2	277	8	and	and	CC
cord-017527-ylng1us2	277	9	the	the	DT
cord-017527-ylng1us2	277	10	use	use	NN
cord-017527-ylng1us2	277	11	of	of	IN
cord-017527-ylng1us2	277	12	a	a	DT
cord-017527-ylng1us2	277	13	BSC	BSC	NNP
cord-017527-ylng1us2	277	14	is	be	VBZ
cord-017527-ylng1us2	277	15	usually	usually	RB
cord-017527-ylng1us2	277	16	the	the	DT
cord-017527-ylng1us2	277	17	norm	norm	NN
cord-017527-ylng1us2	277	18	in	in	IN
cord-017527-ylng1us2	277	19	most	most	JJS
cord-017527-ylng1us2	277	20	laboratories	laboratory	NNS
cord-017527-ylng1us2	277	21	dealing	deal	VBG
cord-017527-ylng1us2	277	22	with	with	IN
cord-017527-ylng1us2	277	23	cell	cell	NN
cord-017527-ylng1us2	277	24	culturing	culturing	NN
cord-017527-ylng1us2	277	25	,	,	,
cord-017527-ylng1us2	277	26	we	-PRON-	PRP
cord-017527-ylng1us2	277	27	think	think	VBP
cord-017527-ylng1us2	277	28	that	that	IN
cord-017527-ylng1us2	277	29	BSL1	BSL1	NNP
cord-017527-ylng1us2	277	30	laboratories	laboratory	NNS
cord-017527-ylng1us2	277	31	can	can	MD
cord-017527-ylng1us2	277	32	relatively	relatively	RB
cord-017527-ylng1us2	277	33	easily	easily	RB
cord-017527-ylng1us2	277	34	be	be	VB
cord-017527-ylng1us2	277	35	upgraded	upgrade	VBN
cord-017527-ylng1us2	277	36	to	to	IN
cord-017527-ylng1us2	277	37	BSL2	BSL2	NNP
cord-017527-ylng1us2	277	38	facilities	facility	NNS
cord-017527-ylng1us2	277	39	by	by	IN
cord-017527-ylng1us2	277	40	implementing	implement	VBG
cord-017527-ylng1us2	277	41	a	a	DT
cord-017527-ylng1us2	277	42	restricted	restricted	JJ
cord-017527-ylng1us2	277	43	number	number	NN
cord-017527-ylng1us2	277	44	of	of	IN
cord-017527-ylng1us2	277	45	simple	simple	JJ
cord-017527-ylng1us2	277	46	additional	additional	JJ
cord-017527-ylng1us2	277	47	safety	safety	NN
cord-017527-ylng1us2	277	48	measures	measure	NNS
cord-017527-ylng1us2	277	49	.	.	.
cord-017527-ylng1us2	278	1	It	-PRON-	PRP
cord-017527-ylng1us2	278	2	is	be	VBZ
cord-017527-ylng1us2	278	3	important	important	JJ
cord-017527-ylng1us2	278	4	to	to	TO
cord-017527-ylng1us2	278	5	notice	notice	VB
cord-017527-ylng1us2	278	6	that	that	IN
cord-017527-ylng1us2	278	7	horizontal	horizontal	JJ
cord-017527-ylng1us2	278	8	laminar	laminar	JJ
cord-017527-ylng1us2	278	9	air	air	NN
cord-017527-ylng1us2	278	10	flows	flow	NNS
cord-017527-ylng1us2	278	11	and	and	CC
cord-017527-ylng1us2	278	12	clean	clean	JJ
cord-017527-ylng1us2	278	13	benches	bench	NNS
cord-017527-ylng1us2	278	14	minimise	minimise	VBP
cord-017527-ylng1us2	278	15	the	the	DT
cord-017527-ylng1us2	278	16	risk	risk	NN
cord-017527-ylng1us2	278	17	of	of	IN
cord-017527-ylng1us2	278	18	adventitious	adventitious	JJ
cord-017527-ylng1us2	278	19	contamination	contamination	NN
cord-017527-ylng1us2	278	20	of	of	IN
cord-017527-ylng1us2	278	21	the	the	DT
cord-017527-ylng1us2	278	22	cell	cell	NN
cord-017527-ylng1us2	278	23	cultures	culture	NNS
cord-017527-ylng1us2	278	24	,	,	,
cord-017527-ylng1us2	278	25	however	however	RB
cord-017527-ylng1us2	278	26	they	-PRON-	PRP
cord-017527-ylng1us2	278	27	offer	offer	VBP
cord-017527-ylng1us2	278	28	no	no	DT
cord-017527-ylng1us2	278	29	protection	protection	NN
cord-017527-ylng1us2	278	30	for	for	IN
cord-017527-ylng1us2	278	31	the	the	DT
cord-017527-ylng1us2	278	32	manipulator	manipulator	NN
cord-017527-ylng1us2	278	33	or	or	CC
cord-017527-ylng1us2	278	34	the	the	DT
cord-017527-ylng1us2	278	35	environment	environment	NN
cord-017527-ylng1us2	278	36	.	.	.
cord-017527-ylng1us2	279	1	Bearing	bear	VBG
cord-017527-ylng1us2	279	2	in	in	IN
cord-017527-ylng1us2	279	3	mind	mind	NN
cord-017527-ylng1us2	279	4	that	that	IN
cord-017527-ylng1us2	279	5	biosafety	biosafety	NN
cord-017527-ylng1us2	279	6	measures	measure	NNS
cord-017527-ylng1us2	279	7	intend	intend	VBP
cord-017527-ylng1us2	279	8	to	to	TO
cord-017527-ylng1us2	279	9	provide	provide	VB
cord-017527-ylng1us2	279	10	a	a	DT
cord-017527-ylng1us2	279	11	maximal	maximal	JJ
cord-017527-ylng1us2	279	12	protection	protection	NN
cord-017527-ylng1us2	279	13	of	of	IN
cord-017527-ylng1us2	279	14	human	human	JJ
cord-017527-ylng1us2	279	15	health	health	NN
cord-017527-ylng1us2	279	16	and	and	CC
cord-017527-ylng1us2	279	17	the	the	DT
cord-017527-ylng1us2	279	18	environment	environment	NN
cord-017527-ylng1us2	279	19	,	,	,
cord-017527-ylng1us2	279	20	it	-PRON-	PRP
cord-017527-ylng1us2	279	21	is	be	VBZ
cord-017527-ylng1us2	279	22	important	important	JJ
cord-017527-ylng1us2	279	23	to	to	TO
cord-017527-ylng1us2	279	24	note	note	VB
cord-017527-ylng1us2	279	25	that	that	IN
cord-017527-ylng1us2	279	26	the	the	DT
cord-017527-ylng1us2	279	27	sole	sole	JJ
cord-017527-ylng1us2	279	28	use	use	NN
cord-017527-ylng1us2	279	29	of	of	IN
cord-017527-ylng1us2	279	30	a	a	DT
cord-017527-ylng1us2	279	31	horizontal	horizontal	JJ
cord-017527-ylng1us2	279	32	laminar	laminar	JJ
cord-017527-ylng1us2	279	33	"	"	``
cord-017527-ylng1us2	279	34	clean	clean	JJ
cord-017527-ylng1us2	279	35	bench	bench	NN
cord-017527-ylng1us2	279	36	"	"	''
cord-017527-ylng1us2	279	37	should	should	MD
cord-017527-ylng1us2	279	38	be	be	VB
cord-017527-ylng1us2	279	39	prohibited	prohibit	VBN
cord-017527-ylng1us2	279	40	.	.	.
cord-017527-ylng1us2	280	1	Based	base	VBN
cord-017527-ylng1us2	280	2	on	on	IN
cord-017527-ylng1us2	280	3	,	,	,
cord-017527-ylng1us2	280	4	but	but	CC
cord-017527-ylng1us2	280	5	not	not	RB
cord-017527-ylng1us2	280	6	limited	limited	JJ
cord-017527-ylng1us2	280	7	to	to	IN
cord-017527-ylng1us2	280	8	,	,	,
cord-017527-ylng1us2	280	9	key	key	JJ
cord-017527-ylng1us2	280	10	features	feature	NNS
cord-017527-ylng1us2	280	11	of	of	IN
cord-017527-ylng1us2	280	12	risk	risk	NN
cord-017527-ylng1us2	280	13	assessment	assessment	NN
cord-017527-ylng1us2	280	14	and	and	CC
cord-017527-ylng1us2	280	15	the	the	DT
cord-017527-ylng1us2	280	16	type	type	NN
cord-017527-ylng1us2	280	17	of	of	IN
cord-017527-ylng1us2	280	18	manipulation	manipulation	NN
cord-017527-ylng1us2	280	19	performed	perform	VBN
cord-017527-ylng1us2	280	20	as	as	IN
cord-017527-ylng1us2	280	21	discussed	discuss	VBN
cord-017527-ylng1us2	280	22	in	in	IN
cord-017527-ylng1us2	280	23	former	former	JJ
cord-017527-ylng1us2	280	24	paragraphs	paragraph	NNS
cord-017527-ylng1us2	280	25	,	,	,
cord-017527-ylng1us2	280	26	we	-PRON-	PRP
cord-017527-ylng1us2	280	27	developed	develop	VBD
cord-017527-ylng1us2	280	28	a	a	DT
cord-017527-ylng1us2	280	29	flow	flow	NN
cord-017527-ylng1us2	280	30	diagram	diagram	NN
cord-017527-ylng1us2	280	31	providing	provide	VBG
cord-017527-ylng1us2	280	32	the	the	DT
cord-017527-ylng1us2	280	33	cell	cell	NN
cord-017527-ylng1us2	280	34	culture	culture	NN
cord-017527-ylng1us2	280	35	users	user	NNS
cord-017527-ylng1us2	280	36	a	a	DT
cord-017527-ylng1us2	280	37	schematic	schematic	JJ
cord-017527-ylng1us2	280	38	guidance	guidance	NN
cord-017527-ylng1us2	280	39	for	for	IN
cord-017527-ylng1us2	280	40	the	the	DT
cord-017527-ylng1us2	280	41	assignment	assignment	NN
cord-017527-ylng1us2	280	42	of	of	IN
cord-017527-ylng1us2	280	43	an	an	DT
cord-017527-ylng1us2	280	44	appropriate	appropriate	JJ
cord-017527-ylng1us2	280	45	containment	containment	NN
cord-017527-ylng1us2	280	46	level	level	NN
cord-017527-ylng1us2	280	47	when	when	WRB
cord-017527-ylng1us2	280	48	manipulating	manipulate	VBG
cord-017527-ylng1us2	280	49	human	human	JJ
cord-017527-ylng1us2	280	50	or	or	CC
cord-017527-ylng1us2	280	51	primate	primate	JJ
cord-017527-ylng1us2	280	52	cells	cell	NNS
cord-017527-ylng1us2	280	53	in	in	IN
cord-017527-ylng1us2	280	54	vitro	vitro	FW
cord-017527-ylng1us2	280	55	(	(	-LRB-
cord-017527-ylng1us2	280	56	Fig	Fig	NNP
cord-017527-ylng1us2	280	57	.	.	NNP
cord-017527-ylng1us2	280	58	22.3	22.3	CD
cord-017527-ylng1us2	280	59	)	)	-RRB-
cord-017527-ylng1us2	280	60	.	.	.
cord-017527-ylng1us2	281	1	This	this	DT
cord-017527-ylng1us2	281	2	flowchart	flowchart	NN
cord-017527-ylng1us2	281	3	is	be	VBZ
cord-017527-ylng1us2	281	4	indicative	indicative	JJ
cord-017527-ylng1us2	281	5	and	and	CC
cord-017527-ylng1us2	281	6	should	should	MD
cord-017527-ylng1us2	281	7	be	be	VB
cord-017527-ylng1us2	281	8	applied	apply	VBN
cord-017527-ylng1us2	282	1	and/or	and/or	CC
cord-017527-ylng1us2	282	2	reconsidered	reconsider	VBN
cord-017527-ylng1us2	282	3	according	accord	VBG
cord-017527-ylng1us2	282	4	to	to	IN
cord-017527-ylng1us2	282	5	case	case	VB
cord-017527-ylng1us2	282	6	specific	specific	JJ
cord-017527-ylng1us2	282	7	conditions	condition	NNS
cord-017527-ylng1us2	282	8	and	and	CC
cord-017527-ylng1us2	282	9	risk	risk	NN
cord-017527-ylng1us2	282	10	assessments	assessment	NNS
cord-017527-ylng1us2	282	11	proper	proper	JJ
cord-017527-ylng1us2	282	12	to	to	IN
cord-017527-ylng1us2	282	13	the	the	DT
cord-017527-ylng1us2	282	14	activities	activity	NNS
cord-017527-ylng1us2	282	15	performed	perform	VBN
cord-017527-ylng1us2	282	16	.	.	.
cord-017527-ylng1us2	283	1	Whenever	whenever	WRB
cord-017527-ylng1us2	283	2	possible	possible	JJ
cord-017527-ylng1us2	283	3	approaches	approach	NNS
cord-017527-ylng1us2	283	4	developed	develop	VBN
cord-017527-ylng1us2	283	5	to	to	TO
cord-017527-ylng1us2	283	6	ab	ab	VB
cord-017527-ylng1us2	283	7	initio	initio	NNP
cord-017527-ylng1us2	283	8	reduce	reduce	VB
cord-017527-ylng1us2	283	9	the	the	DT
cord-017527-ylng1us2	283	10	risk	risk	NN
cord-017527-ylng1us2	283	11	associated	associate	VBN
cord-017527-ylng1us2	283	12	with	with	IN
cord-017527-ylng1us2	283	13	the	the	DT
cord-017527-ylng1us2	283	14	handling	handling	NN
cord-017527-ylng1us2	283	15	of	of	IN
cord-017527-ylng1us2	283	16	animal	animal	NN
cord-017527-ylng1us2	283	17	cell	cell	NN
cord-017527-ylng1us2	283	18	cultures	culture	NNS
cord-017527-ylng1us2	283	19	should	should	MD
cord-017527-ylng1us2	283	20	be	be	VB
cord-017527-ylng1us2	283	21	favoured	favour	VBN
cord-017527-ylng1us2	283	22	.	.	.
cord-017527-ylng1us2	284	1	Such	such	JJ
cord-017527-ylng1us2	284	2	approaches	approach	NNS
cord-017527-ylng1us2	284	3	involve	involve	VBP
cord-017527-ylng1us2	284	4	the	the	DT
cord-017527-ylng1us2	284	5	use	use	NN
cord-017527-ylng1us2	284	6	of	of	IN
cord-017527-ylng1us2	284	7	dedicated	dedicated	JJ
cord-017527-ylng1us2	284	8	instruments	instrument	NNS
cord-017527-ylng1us2	284	9	or	or	CC
cord-017527-ylng1us2	284	10	safer	safe	JJR
cord-017527-ylng1us2	284	11	biological	biological	JJ
cord-017527-ylng1us2	284	12	material	material	NN
cord-017527-ylng1us2	284	13	.	.	.
cord-017527-ylng1us2	285	1	The	the	DT
cord-017527-ylng1us2	285	2	examples	example	NNS
cord-017527-ylng1us2	285	3	hereunder	hereunder	NN
cord-017527-ylng1us2	285	4	illustrate	illustrate	VBP
cord-017527-ylng1us2	285	5	how	how	WRB
cord-017527-ylng1us2	285	6	the	the	DT
cord-017527-ylng1us2	285	7	choice	choice	NN
cord-017527-ylng1us2	285	8	to	to	TO
cord-017527-ylng1us2	285	9	apply	apply	VB
cord-017527-ylng1us2	285	10	one	one	CD
cord-017527-ylng1us2	285	11	or	or	CC
cord-017527-ylng1us2	285	12	several	several	JJ
cord-017527-ylng1us2	285	13	of	of	IN
cord-017527-ylng1us2	285	14	these	these	DT
cord-017527-ylng1us2	285	15	approaches	approach	NNS
cord-017527-ylng1us2	285	16	is	be	VBZ
cord-017527-ylng1us2	285	17	determined	determine	VBN
cord-017527-ylng1us2	285	18	on	on	IN
cord-017527-ylng1us2	285	19	a	a	DT
cord-017527-ylng1us2	285	20	case	case	NN
cord-017527-ylng1us2	285	21	-	-	HYPH
cord-017527-ylng1us2	285	22	by	by	IN
cord-017527-ylng1us2	285	23	-	-	HYPH
cord-017527-ylng1us2	285	24	case	case	NN
cord-017527-ylng1us2	285	25	basis	basis	NN
cord-017527-ylng1us2	285	26	,	,	,
cord-017527-ylng1us2	285	27	depending	depend	VBG
cord-017527-ylng1us2	285	28	on	on	IN
cord-017527-ylng1us2	285	29	the	the	DT
cord-017527-ylng1us2	285	30	intrinsic	intrinsic	JJ
cord-017527-ylng1us2	285	31	characteristics	characteristic	NNS
cord-017527-ylng1us2	285	32	of	of	IN
cord-017527-ylng1us2	285	33	the	the	DT
cord-017527-ylng1us2	285	34	biological	biological	JJ
cord-017527-ylng1us2	285	35	material	material	NN
cord-017527-ylng1us2	285	36	and	and	CC
cord-017527-ylng1us2	285	37	the	the	DT
cord-017527-ylng1us2	285	38	intended	intend	VBN
cord-017527-ylng1us2	285	39	use	use	NN
cord-017527-ylng1us2	285	40	.	.	.
cord-017527-ylng1us2	286	1	During	during	IN
cord-017527-ylng1us2	286	2	the	the	DT
cord-017527-ylng1us2	286	3	last	last	JJ
cord-017527-ylng1us2	286	4	couple	couple	NN
cord-017527-ylng1us2	286	5	of	of	IN
cord-017527-ylng1us2	286	6	years	year	NNS
cord-017527-ylng1us2	286	7	instruments	instrument	NNS
cord-017527-ylng1us2	286	8	enabling	enable	VBG
cord-017527-ylng1us2	286	9	automated	automate	VBN
cord-017527-ylng1us2	286	10	mechanical	mechanical	JJ
cord-017527-ylng1us2	286	11	passaging	passaging	NN
cord-017527-ylng1us2	286	12	and	and	CC
cord-017527-ylng1us2	286	13	nutrient	nutrient	NN
cord-017527-ylng1us2	286	14	supply	supply	NN
cord-017527-ylng1us2	286	15	for	for	IN
cord-017527-ylng1us2	286	16	in	in	FW
cord-017527-ylng1us2	286	17	vitro	vitro	FW
cord-017527-ylng1us2	286	18	cell	cell	NN
cord-017527-ylng1us2	286	19	expansion	expansion	NN
cord-017527-ylng1us2	286	20	have	have	VBP
cord-017527-ylng1us2	286	21	been	be	VBN
cord-017527-ylng1us2	286	22	developed	develop	VBN
cord-017527-ylng1us2	286	23	for	for	IN
cord-017527-ylng1us2	286	24	primary	primary	JJ
cord-017527-ylng1us2	286	25	cells	cell	NNS
cord-017527-ylng1us2	286	26	,	,	,
cord-017527-ylng1us2	286	27	adherent	adherent	JJ
cord-017527-ylng1us2	286	28	and	and	CC
cord-017527-ylng1us2	286	29	non	non	JJ
cord-017527-ylng1us2	286	30	-	-	JJ
cord-017527-ylng1us2	286	31	adherent	adherent	JJ
cord-017527-ylng1us2	286	32	mammalian	mammalian	JJ
cord-017527-ylng1us2	286	33	cells	cell	NNS
cord-017527-ylng1us2	286	34	(	(	-LRB-
cord-017527-ylng1us2	286	35	Kato	Kato	NNP
cord-017527-ylng1us2	286	36	et	et	NNP
cord-017527-ylng1us2	286	37	al	al	NNP
cord-017527-ylng1us2	286	38	.	.	NNP
cord-017527-ylng1us2	286	39	2010	2010	CD
cord-017527-ylng1us2	286	40	;	;	:
cord-017527-ylng1us2	286	41	Thomas	Thomas	NNP
cord-017527-ylng1us2	286	42	and	and	CC
cord-017527-ylng1us2	286	43	Ratcliffe	Ratcliffe	NNP
cord-017527-ylng1us2	286	44	2012	2012	CD
cord-017527-ylng1us2	286	45	)	)	-RRB-
cord-017527-ylng1us2	286	46	.	.	.
cord-017527-ylng1us2	287	1	Some	some	DT
cord-017527-ylng1us2	287	2	of	of	IN
cord-017527-ylng1us2	287	3	these	these	DT
cord-017527-ylng1us2	287	4	developments	development	NNS
cord-017527-ylng1us2	287	5	also	also	RB
cord-017527-ylng1us2	287	6	provide	provide	VBP
cord-017527-ylng1us2	287	7	a	a	DT
cord-017527-ylng1us2	287	8	safer	safe	JJR
cord-017527-ylng1us2	287	9	approach	approach	NN
cord-017527-ylng1us2	287	10	with	with	IN
cord-017527-ylng1us2	287	11	respect	respect	NN
cord-017527-ylng1us2	287	12	to	to	IN
cord-017527-ylng1us2	287	13	biosafety	biosafety	NN
cord-017527-ylng1us2	287	14	considerations	consideration	NNS
cord-017527-ylng1us2	287	15	by	by	IN
cord-017527-ylng1us2	287	16	including	include	VBG
cord-017527-ylng1us2	287	17	a	a	DT
cord-017527-ylng1us2	287	18	biosafety	biosafety	NN
cord-017527-ylng1us2	287	19	module	module	NN
cord-017527-ylng1us2	287	20	in	in	IN
cord-017527-ylng1us2	287	21	the	the	DT
cord-017527-ylng1us2	287	22	design	design	NN
cord-017527-ylng1us2	287	23	of	of	IN
cord-017527-ylng1us2	287	24	such	such	JJ
cord-017527-ylng1us2	287	25	automated	automated	JJ
cord-017527-ylng1us2	287	26	platforms	platform	NNS
cord-017527-ylng1us2	287	27	.	.	.
cord-017527-ylng1us2	288	1	For	for	IN
cord-017527-ylng1us2	288	2	example	example	NN
cord-017527-ylng1us2	288	3	a	a	DT
cord-017527-ylng1us2	288	4	long	long	JJ
cord-017527-ylng1us2	288	5	-	-	HYPH
cord-017527-ylng1us2	288	6	term	term	NN
cord-017527-ylng1us2	288	7	cell	cell	NN
cord-017527-ylng1us2	288	8	culture	culture	NN
cord-017527-ylng1us2	288	9	device	device	NN
cord-017527-ylng1us2	288	10	ensuring	ensure	VBG
cord-017527-ylng1us2	288	11	both	both	CC
cord-017527-ylng1us2	288	12	the	the	DT
cord-017527-ylng1us2	288	13	protection	protection	NN
cord-017527-ylng1us2	288	14	of	of	IN
cord-017527-ylng1us2	288	15	the	the	DT
cord-017527-ylng1us2	288	16	product	product	NN
cord-017527-ylng1us2	288	17	and	and	CC
cord-017527-ylng1us2	288	18	the	the	DT
cord-017527-ylng1us2	288	19	operator	operator	NN
cord-017527-ylng1us2	288	20	has	have	VBZ
cord-017527-ylng1us2	288	21	been	be	VBN
cord-017527-ylng1us2	288	22	designed	design	VBN
cord-017527-ylng1us2	288	23	for	for	IN
cord-017527-ylng1us2	288	24	the	the	DT
cord-017527-ylng1us2	288	25	culturing	culturing	NN
cord-017527-ylng1us2	288	26	of	of	IN
cord-017527-ylng1us2	288	27	embryonic	embryonic	JJ
cord-017527-ylng1us2	288	28	stem	stem	NN
cord-017527-ylng1us2	288	29	cells	cell	NNS
cord-017527-ylng1us2	288	30	in	in	IN
cord-017527-ylng1us2	288	31	an	an	DT
cord-017527-ylng1us2	288	32	antibiotic	antibiotic	JJ
cord-017527-ylng1us2	288	33	-	-	HYPH
cord-017527-ylng1us2	288	34	free	free	JJ
cord-017527-ylng1us2	288	35	medium	medium	NN
cord-017527-ylng1us2	288	36	by	by	IN
cord-017527-ylng1us2	288	37	means	mean	NNS
cord-017527-ylng1us2	288	38	of	of	IN
cord-017527-ylng1us2	288	39	an	an	DT
cord-017527-ylng1us2	288	40	integrated	integrated	JJ
cord-017527-ylng1us2	288	41	automation	automation	NN
cord-017527-ylng1us2	288	42	platform	platform	NN
cord-017527-ylng1us2	288	43	using	use	VBG
cord-017527-ylng1us2	288	44	a	a	DT
cord-017527-ylng1us2	288	45	class	class	NN
cord-017527-ylng1us2	288	46	II	II	NNP
cord-017527-ylng1us2	288	47	BSC	BSC	NNP
cord-017527-ylng1us2	288	48	confining	confine	VBG
cord-017527-ylng1us2	288	49	the	the	DT
cord-017527-ylng1us2	288	50	microwells	microwell	NNS
cord-017527-ylng1us2	288	51	(	(	-LRB-
cord-017527-ylng1us2	288	52	liquid	liquid	JJ
cord-017527-ylng1us2	288	53	handling	handling	NN
cord-017527-ylng1us2	288	54	robot	robot	NN
cord-017527-ylng1us2	288	55	contained	contain	VBN
cord-017527-ylng1us2	288	56	in	in	IN
cord-017527-ylng1us2	288	57	a	a	DT
cord-017527-ylng1us2	288	58	BSC	BSC	NNP
cord-017527-ylng1us2	288	59	)	)	-RRB-
cord-017527-ylng1us2	289	1	(	(	-LRB-
cord-017527-ylng1us2	289	2	Hussain	Hussain	NNP
cord-017527-ylng1us2	289	3	et	et	NNP
cord-017527-ylng1us2	289	4	al	al	NNP
cord-017527-ylng1us2	289	5	.	.	NNP
cord-017527-ylng1us2	289	6	2013	2013	CD
cord-017527-ylng1us2	289	7	)	)	-RRB-
cord-017527-ylng1us2	290	1	An	an	DT
cord-017527-ylng1us2	290	2	automation	automation	NN
cord-017527-ylng1us2	290	3	system	system	NN
cord-017527-ylng1us2	290	4	has	have	VBZ
cord-017527-ylng1us2	290	5	also	also	RB
cord-017527-ylng1us2	290	6	been	be	VBN
cord-017527-ylng1us2	290	7	deployed	deploy	VBN
cord-017527-ylng1us2	290	8	for	for	IN
cord-017527-ylng1us2	290	9	the	the	DT
cord-017527-ylng1us2	290	10	production	production	NN
cord-017527-ylng1us2	290	11	(	(	-LRB-
cord-017527-ylng1us2	290	12	140	140	CD
cord-017527-ylng1us2	290	13	-	-	SYM
cord-017527-ylng1us2	290	14	1,000	1,000	CD
cord-017527-ylng1us2	290	15	ml	ml	NN
cord-017527-ylng1us2	290	16	)	)	-RRB-
cord-017527-ylng1us2	290	17	of	of	IN
cord-017527-ylng1us2	290	18	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	290	19	pseudovirus	pseudovirus	NNP
cord-017527-ylng1us2	290	20	for	for	IN
cord-017527-ylng1us2	290	21	HIV	HIV	NNP
cord-017527-ylng1us2	290	22	vaccine	vaccine	NN
cord-017527-ylng1us2	290	23	trials	trial	NNS
cord-017527-ylng1us2	290	24	in	in	IN
cord-017527-ylng1us2	290	25	compliance	compliance	NN
cord-017527-ylng1us2	290	26	with	with	IN
cord-017527-ylng1us2	290	27	GCLP	GCLP	NNP
cord-017527-ylng1us2	290	28	.	.	.
cord-017527-ylng1us2	291	1	This	this	DT
cord-017527-ylng1us2	291	2	robust	robust	JJ
cord-017527-ylng1us2	291	3	automated	automate	VBN
cord-017527-ylng1us2	291	4	system	system	NN
cord-017527-ylng1us2	291	5	for	for	IN
cord-017527-ylng1us2	291	6	cultivation	cultivation	NN
cord-017527-ylng1us2	291	7	of	of	IN
cord-017527-ylng1us2	291	8	293	293	CD
cord-017527-ylng1us2	291	9	T/17	t/17	CD
cord-017527-ylng1us2	291	10	cells	cell	NNS
cord-017527-ylng1us2	291	11	is	be	VBZ
cord-017527-ylng1us2	291	12	contained	contain	VBN
cord-017527-ylng1us2	291	13	in	in	IN
cord-017527-ylng1us2	291	14	a	a	DT
cord-017527-ylng1us2	291	15	class	class	NN
cord-017527-ylng1us2	291	16	II	II	NNP
cord-017527-ylng1us2	291	17	BSC	BSC	NNP
cord-017527-ylng1us2	291	18	that	that	WDT
cord-017527-ylng1us2	291	19	guarantees	guarantee	VBZ
cord-017527-ylng1us2	291	20	the	the	DT
cord-017527-ylng1us2	291	21	protection	protection	NN
cord-017527-ylng1us2	291	22	of	of	IN
cord-017527-ylng1us2	291	23	the	the	DT
cord-017527-ylng1us2	291	24	workers	worker	NNS
cord-017527-ylng1us2	291	25	,	,	,
cord-017527-ylng1us2	291	26	environment	environment	NN
cord-017527-ylng1us2	291	27	and	and	CC
cord-017527-ylng1us2	291	28	the	the	DT
cord-017527-ylng1us2	291	29	product	product	NN
cord-017527-ylng1us2	291	30	.	.	.
cord-017527-ylng1us2	292	1	This	this	DT
cord-017527-ylng1us2	292	2	system	system	NN
cord-017527-ylng1us2	292	3	can	can	MD
cord-017527-ylng1us2	292	4	be	be	VB
cord-017527-ylng1us2	292	5	implemented	implement	VBN
cord-017527-ylng1us2	292	6	to	to	TO
cord-017527-ylng1us2	292	7	produce	produce	VB
cord-017527-ylng1us2	292	8	other	other	JJ
cord-017527-ylng1us2	292	9	biological	biological	JJ
cord-017527-ylng1us2	292	10	reagents	reagent	NNS
cord-017527-ylng1us2	292	11	under	under	IN
cord-017527-ylng1us2	292	12	standardised	standardised	JJ
cord-017527-ylng1us2	292	13	large	large	JJ
cord-017527-ylng1us2	292	14	-	-	HYPH
cord-017527-ylng1us2	292	15	scale	scale	NN
cord-017527-ylng1us2	292	16	conditions	condition	NNS
cord-017527-ylng1us2	292	17	(	(	-LRB-
cord-017527-ylng1us2	292	18	Schultz	Schultz	NNP
cord-017527-ylng1us2	292	19	et	et	NNP
cord-017527-ylng1us2	292	20	al	al	NNP
cord-017527-ylng1us2	292	21	.	.	NNP
cord-017527-ylng1us2	292	22	2012	2012	CD
cord-017527-ylng1us2	292	23	)	)	-RRB-
cord-017527-ylng1us2	292	24	.	.	.
cord-017527-ylng1us2	293	1	Lowering	lower	VBG
cord-017527-ylng1us2	293	2	the	the	DT
cord-017527-ylng1us2	293	3	hazards	hazard	NNS
cord-017527-ylng1us2	293	4	associated	associate	VBN
cord-017527-ylng1us2	293	5	with	with	IN
cord-017527-ylng1us2	293	6	the	the	DT
cord-017527-ylng1us2	293	7	cell	cell	NN
cord-017527-ylng1us2	293	8	cultures	culture	NNS
cord-017527-ylng1us2	293	9	handled	handle	VBN
cord-017527-ylng1us2	293	10	is	be	VBZ
cord-017527-ylng1us2	293	11	another	another	DT
cord-017527-ylng1us2	293	12	approach	approach	NN
cord-017527-ylng1us2	293	13	that	that	WDT
cord-017527-ylng1us2	293	14	was	be	VBD
cord-017527-ylng1us2	293	15	applied	apply	VBN
cord-017527-ylng1us2	293	16	in	in	IN
cord-017527-ylng1us2	293	17	the	the	DT
cord-017527-ylng1us2	293	18	characterisation	characterisation	NN
cord-017527-ylng1us2	293	19	of	of	IN
cord-017527-ylng1us2	293	20	pandemic	pandemic	NN
cord-017527-ylng1us2	293	21	influenza	influenza	NN
cord-017527-ylng1us2	293	22	viruses	virus	NNS
cord-017527-ylng1us2	293	23	under	under	IN
cord-017527-ylng1us2	293	24	emergency	emergency	NN
cord-017527-ylng1us2	293	25	situations	situation	NNS
cord-017527-ylng1us2	293	26	.	.	.
cord-017527-ylng1us2	294	1	While	while	IN
cord-017527-ylng1us2	294	2	such	such	JJ
cord-017527-ylng1us2	294	3	activities	activity	NNS
cord-017527-ylng1us2	294	4	typically	typically	RB
cord-017527-ylng1us2	294	5	require	require	VBP
cord-017527-ylng1us2	294	6	BSL3	BSL3	NNP
cord-017527-ylng1us2	294	7	conditions	condition	NNS
cord-017527-ylng1us2	294	8	,	,	,
cord-017527-ylng1us2	294	9	inactivation	inactivation	NN
cord-017527-ylng1us2	294	10	protocols	protocol	NNS
cord-017527-ylng1us2	294	11	applied	apply	VBN
cord-017527-ylng1us2	294	12	to	to	IN
cord-017527-ylng1us2	294	13	influenza	influenza	NN
cord-017527-ylng1us2	294	14	virus	virus	NN
cord-017527-ylng1us2	294	15	culture	culture	NN
cord-017527-ylng1us2	294	16	allows	allow	VBZ
cord-017527-ylng1us2	294	17	for	for	IN
cord-017527-ylng1us2	294	18	performing	perform	VBG
cord-017527-ylng1us2	294	19	the	the	DT
cord-017527-ylng1us2	294	20	virological	virological	JJ
cord-017527-ylng1us2	294	21	and	and	CC
cord-017527-ylng1us2	294	22	immunological	immunological	JJ
cord-017527-ylng1us2	294	23	assays	assay	NNS
cord-017527-ylng1us2	294	24	under	under	IN
cord-017527-ylng1us2	294	25	BSL2	BSL2	NNP
cord-017527-ylng1us2	294	26	conditions	condition	NNS
cord-017527-ylng1us2	294	27	(	(	-LRB-
cord-017527-ylng1us2	294	28	Jonges	Jonges	NNP
cord-017527-ylng1us2	294	29	et	et	NNP
cord-017527-ylng1us2	294	30	al	al	NNP
cord-017527-ylng1us2	294	31	.	.	NNP
cord-017527-ylng1us2	294	32	2010	2010	CD
cord-017527-ylng1us2	294	33	)	)	-RRB-
cord-017527-ylng1us2	294	34	.	.	.
cord-017527-ylng1us2	295	1	Another	another	DT
cord-017527-ylng1us2	295	2	example	example	NN
cord-017527-ylng1us2	295	3	where	where	WRB
cord-017527-ylng1us2	295	4	the	the	DT
cord-017527-ylng1us2	295	5	assignment	assignment	NN
cord-017527-ylng1us2	295	6	of	of	IN
cord-017527-ylng1us2	295	7	a	a	DT
cord-017527-ylng1us2	295	8	less	less	RBR
cord-017527-ylng1us2	295	9	stringent	stringent	JJ
cord-017527-ylng1us2	295	10	containment	containment	NN
cord-017527-ylng1us2	295	11	level	level	NN
cord-017527-ylng1us2	295	12	was	be	VBD
cord-017527-ylng1us2	295	13	enabled	enable	VBN
cord-017527-ylng1us2	295	14	relates	relate	NNS
cord-017527-ylng1us2	295	15	to	to	IN
cord-017527-ylng1us2	295	16	the	the	DT
cord-017527-ylng1us2	295	17	use	use	NN
cord-017527-ylng1us2	295	18	of	of	IN
cord-017527-ylng1us2	295	19	insect	insect	NN
cord-017527-ylng1us2	295	20	cells	cell	NNS
cord-017527-ylng1us2	295	21	and	and	CC
cord-017527-ylng1us2	295	22	GM	GM	NNP
cord-017527-ylng1us2	295	23	bacteriophage	bacteriophage	NN
cord-017527-ylng1us2	295	24	Lambda	Lambda	NNP
cord-017527-ylng1us2	295	25	capsids	capsid	NNS
cord-017527-ylng1us2	295	26	in	in	IN
cord-017527-ylng1us2	295	27	cases	case	NNS
cord-017527-ylng1us2	295	28	where	where	WRB
cord-017527-ylng1us2	295	29	usually	usually	RB
cord-017527-ylng1us2	295	30	the	the	DT
cord-017527-ylng1us2	295	31	maintenance	maintenance	NN
cord-017527-ylng1us2	295	32	of	of	IN
cord-017527-ylng1us2	295	33	infectious	infectious	JJ
cord-017527-ylng1us2	295	34	stocks	stock	NNS
cord-017527-ylng1us2	295	35	of	of	IN
cord-017527-ylng1us2	295	36	highly	highly	RB
cord-017527-ylng1us2	295	37	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	295	38	or	or	CC
cord-017527-ylng1us2	295	39	emerging	emerge	VBG
cord-017527-ylng1us2	295	40	influenza	influenza	NN
cord-017527-ylng1us2	295	41	viruses	virus	NNS
cord-017527-ylng1us2	295	42	is	be	VBZ
cord-017527-ylng1us2	295	43	involved	involve	VBN
cord-017527-ylng1us2	295	44	(	(	-LRB-
cord-017527-ylng1us2	295	45	Domm	Domm	NNP
cord-017527-ylng1us2	295	46	et	et	FW
cord-017527-ylng1us2	295	47	al	al	NNP
cord-017527-ylng1us2	295	48	.	.	NNP
cord-017527-ylng1us2	295	49	2014	2014	CD
cord-017527-ylng1us2	295	50	)	)	-RRB-
cord-017527-ylng1us2	295	51	.	.	.
cord-017527-ylng1us2	296	1	The	the	DT
cord-017527-ylng1us2	296	2	bacteriophages	bacteriophage	NNS
cord-017527-ylng1us2	296	3	are	be	VBP
cord-017527-ylng1us2	296	4	"	"	``
cord-017527-ylng1us2	296	5	decorated	decorate	VBN
cord-017527-ylng1us2	296	6	"	"	''
cord-017527-ylng1us2	296	7	by	by	IN
cord-017527-ylng1us2	296	8	the	the	DT
cord-017527-ylng1us2	296	9	viral	viral	JJ
cord-017527-ylng1us2	296	10	glycoproteins	glycoprotein	NNS
cord-017527-ylng1us2	296	11	of	of	IN
cord-017527-ylng1us2	296	12	interest	interest	NN
cord-017527-ylng1us2	296	13	in	in	IN
cord-017527-ylng1us2	296	14	an	an	DT
cord-017527-ylng1us2	296	15	insect	insect	NN
cord-017527-ylng1us2	296	16	cell	cell	NN
cord-017527-ylng1us2	296	17	-	-	HYPH
cord-017527-ylng1us2	296	18	derived	derive	VBN
cord-017527-ylng1us2	296	19	system	system	NN
cord-017527-ylng1us2	296	20	so	so	IN
cord-017527-ylng1us2	296	21	as	as	IN
cord-017527-ylng1us2	296	22	to	to	TO
cord-017527-ylng1us2	296	23	use	use	VB
cord-017527-ylng1us2	296	24	hemagglutinin	hemagglutinin	NN
cord-017527-ylng1us2	296	25	displaying	display	VBG
cord-017527-ylng1us2	296	26	bacteriophages	bacteriophage	NNS
cord-017527-ylng1us2	296	27	in	in	IN
cord-017527-ylng1us2	296	28	hemagglutination	hemagglutination	NN
cord-017527-ylng1us2	296	29	-	-	HYPH
cord-017527-ylng1us2	296	30	inhibition	inhibition	NN
cord-017527-ylng1us2	296	31	assay	assay	NN
cord-017527-ylng1us2	296	32	on	on	IN
cord-017527-ylng1us2	296	33	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	296	34	influenza	influenza	NN
cord-017527-ylng1us2	296	35	viruses	virus	NNS
cord-017527-ylng1us2	296	36	.	.	.
cord-017527-ylng1us2	297	1	The	the	DT
cord-017527-ylng1us2	297	2	same	same	JJ
cord-017527-ylng1us2	297	3	approach	approach	NN
cord-017527-ylng1us2	297	4	was	be	VBD
cord-017527-ylng1us2	297	5	already	already	RB
cord-017527-ylng1us2	297	6	applied	apply	VBN
cord-017527-ylng1us2	297	7	for	for	IN
cord-017527-ylng1us2	297	8	HIV	HIV	NNP
cord-017527-ylng1us2	297	9	-	-	HYPH
cord-017527-ylng1us2	297	10	envelope	envelope	NN
cord-017527-ylng1us2	297	11	protein	protein	NN
cord-017527-ylng1us2	297	12	(	(	-LRB-
cord-017527-ylng1us2	297	13	Mattiacio	Mattiacio	NNP
cord-017527-ylng1us2	297	14	et	et	FW
cord-017527-ylng1us2	297	15	al	al	NNP
cord-017527-ylng1us2	297	16	.	.	NNP
cord-017527-ylng1us2	297	17	2011	2011	CD
cord-017527-ylng1us2	297	18	)	)	-RRB-
cord-017527-ylng1us2	297	19	.	.	.
cord-017527-ylng1us2	298	1	With	with	IN
cord-017527-ylng1us2	298	2	regards	regard	NNS
cord-017527-ylng1us2	298	3	to	to	IN
cord-017527-ylng1us2	298	4	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	299	1	in	in	IN
cord-017527-ylng1us2	299	2	vitro	vitro	FW
cord-017527-ylng1us2	299	3	testing	testing	NN
cord-017527-ylng1us2	299	4	,	,	,
cord-017527-ylng1us2	299	5	a	a	DT
cord-017527-ylng1us2	299	6	non	non	JJ
cord-017527-ylng1us2	299	7	-	-	JJ
cord-017527-ylng1us2	299	8	infectious	infectious	JJ
cord-017527-ylng1us2	299	9	cell	cell	NN
cord-017527-ylng1us2	299	10	-	-	HYPH
cord-017527-ylng1us2	299	11	based	base	VBN
cord-017527-ylng1us2	299	12	assay	assay	NN
cord-017527-ylng1us2	299	13	to	to	TO
cord-017527-ylng1us2	299	14	assess	assess	VB
cord-017527-ylng1us2	299	15	the	the	DT
cord-017527-ylng1us2	299	16	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	299	17	susceptibility	susceptibility	NN
cord-017527-ylng1us2	299	18	to	to	IN
cord-017527-ylng1us2	299	19	protease	protease	NN
cord-017527-ylng1us2	299	20	inhibitors	inhibitor	NNS
cord-017527-ylng1us2	299	21	was	be	VBD
cord-017527-ylng1us2	299	22	also	also	RB
cord-017527-ylng1us2	299	23	developed	develop	VBN
cord-017527-ylng1us2	299	24	recently	recently	RB
cord-017527-ylng1us2	300	1	(	(	-LRB-
cord-017527-ylng1us2	300	2	Buzon	Buzon	NNP
cord-017527-ylng1us2	300	3	et	et	NNP
cord-017527-ylng1us2	300	4	al	al	NNP
cord-017527-ylng1us2	300	5	.	.	NNP
cord-017527-ylng1us2	300	6	2012	2012	CD
cord-017527-ylng1us2	300	7	)	)	-RRB-
cord-017527-ylng1us2	300	8	.	.	.
cord-017527-ylng1us2	301	1	Here	here	RB
cord-017527-ylng1us2	301	2	again	again	RB
cord-017527-ylng1us2	301	3	,	,	,
cord-017527-ylng1us2	301	4	activities	activity	NNS
cord-017527-ylng1us2	301	5	that	that	WDT
cord-017527-ylng1us2	301	6	normally	normally	RB
cord-017527-ylng1us2	301	7	require	require	VBP
cord-017527-ylng1us2	301	8	relatively	relatively	RB
cord-017527-ylng1us2	301	9	high	high	JJ
cord-017527-ylng1us2	301	10	containment	containment	NN
cord-017527-ylng1us2	301	11	level	level	NN
cord-017527-ylng1us2	301	12	can	can	MD
cord-017527-ylng1us2	301	13	be	be	VB
cord-017527-ylng1us2	301	14	performed	perform	VBN
cord-017527-ylng1us2	301	15	in	in	IN
cord-017527-ylng1us2	301	16	facilities	facility	NNS
cord-017527-ylng1us2	301	17	with	with	IN
cord-017527-ylng1us2	301	18	less	less	RBR
cord-017527-ylng1us2	301	19	expensive	expensive	JJ
cord-017527-ylng1us2	301	20	infrastructure	infrastructure	NN
cord-017527-ylng1us2	301	21	.	.	.
cord-017527-ylng1us2	302	1	It	-PRON-	PRP
cord-017527-ylng1us2	302	2	also	also	RB
cord-017527-ylng1us2	302	3	shows	show	VBZ
cord-017527-ylng1us2	302	4	that	that	IN
cord-017527-ylng1us2	302	5	careful	careful	JJ
cord-017527-ylng1us2	302	6	consideration	consideration	NN
cord-017527-ylng1us2	302	7	of	of	IN
cord-017527-ylng1us2	302	8	the	the	DT
cord-017527-ylng1us2	302	9	material	material	NN
cord-017527-ylng1us2	302	10	handled	handle	VBN
cord-017527-ylng1us2	302	11	can	can	MD
cord-017527-ylng1us2	302	12	lead	lead	VB
cord-017527-ylng1us2	302	13	to	to	IN
cord-017527-ylng1us2	302	14	costeffective	costeffective	JJ
cord-017527-ylng1us2	302	15	choice	choice	NN
cord-017527-ylng1us2	302	16	while	while	IN
cord-017527-ylng1us2	302	17	maintaining	maintain	VBG
cord-017527-ylng1us2	302	18	the	the	DT
cord-017527-ylng1us2	302	19	same	same	JJ
cord-017527-ylng1us2	302	20	objectives	objective	NNS
cord-017527-ylng1us2	302	21	.	.	.
cord-017527-ylng1us2	303	1	Biosafety	biosafety	NN
cord-017527-ylng1us2	303	2	is	be	VBZ
cord-017527-ylng1us2	303	3	an	an	DT
cord-017527-ylng1us2	303	4	internationally	internationally	RB
cord-017527-ylng1us2	303	5	recognized	recognize	VBN
cord-017527-ylng1us2	303	6	concept	concept	NN
cord-017527-ylng1us2	303	7	referring	refer	VBG
cord-017527-ylng1us2	303	8	to	to	IN
cord-017527-ylng1us2	303	9	the	the	DT
cord-017527-ylng1us2	303	10	maximal	maximal	JJ
cord-017527-ylng1us2	303	11	protection	protection	NN
cord-017527-ylng1us2	303	12	of	of	IN
cord-017527-ylng1us2	303	13	laboratory	laboratory	NN
cord-017527-ylng1us2	303	14	workers	worker	NNS
cord-017527-ylng1us2	303	15	,	,	,
cord-017527-ylng1us2	303	16	public	public	JJ
cord-017527-ylng1us2	303	17	health	health	NN
cord-017527-ylng1us2	303	18	and	and	CC
cord-017527-ylng1us2	303	19	the	the	DT
cord-017527-ylng1us2	303	20	environment	environment	NN
cord-017527-ylng1us2	303	21	from	from	IN
cord-017527-ylng1us2	303	22	the	the	DT
cord-017527-ylng1us2	303	23	possible	possible	JJ
cord-017527-ylng1us2	303	24	adverse	adverse	JJ
cord-017527-ylng1us2	303	25	effects	effect	NNS
cord-017527-ylng1us2	303	26	associated	associate	VBN
cord-017527-ylng1us2	303	27	to	to	IN
cord-017527-ylng1us2	303	28	the	the	DT
cord-017527-ylng1us2	303	29	use	use	NN
cord-017527-ylng1us2	303	30	of	of	IN
cord-017527-ylng1us2	303	31	organisms	organism	NNS
cord-017527-ylng1us2	303	32	and	and	CC
cord-017527-ylng1us2	303	33	microorganisms	microorganism	NNS
cord-017527-ylng1us2	303	34	(	(	-LRB-
cord-017527-ylng1us2	303	35	genetically	genetically	RB
cord-017527-ylng1us2	303	36	modified	modify	VBN
cord-017527-ylng1us2	303	37	or	or	CC
cord-017527-ylng1us2	303	38	not	not	RB
cord-017527-ylng1us2	303	39	)	)	-RRB-
cord-017527-ylng1us2	303	40	.	.	.
cord-017527-ylng1us2	304	1	Within	within	IN
cord-017527-ylng1us2	304	2	this	this	DT
cord-017527-ylng1us2	304	3	respect	respect	NN
cord-017527-ylng1us2	304	4	activities	activity	NNS
cord-017527-ylng1us2	304	5	involving	involve	VBG
cord-017527-ylng1us2	304	6	the	the	DT
cord-017527-ylng1us2	304	7	use	use	NN
cord-017527-ylng1us2	304	8	of	of	IN
cord-017527-ylng1us2	304	9	animal	animal	NN
cord-017527-ylng1us2	304	10	cell	cell	NN
cord-017527-ylng1us2	304	11	cultures	culture	NNS
cord-017527-ylng1us2	304	12	for	for	IN
cord-017527-ylng1us2	304	13	fundamental	fundamental	JJ
cord-017527-ylng1us2	304	14	research	research	NN
cord-017527-ylng1us2	304	15	,	,	,
cord-017527-ylng1us2	304	16	R&D	r&d	NN
cord-017527-ylng1us2	304	17	or	or	CC
cord-017527-ylng1us2	304	18	in	in	IN
cord-017527-ylng1us2	304	19	vitro	vitro	FW
cord-017527-ylng1us2	304	20	diagnosis	diagnosis	NN
cord-017527-ylng1us2	304	21	purposes	purpose	NNS
cord-017527-ylng1us2	304	22	pose	pose	VBP
cord-017527-ylng1us2	304	23	biosafety	biosafety	NN
cord-017527-ylng1us2	304	24	considerations	consideration	NNS
cord-017527-ylng1us2	304	25	as	as	RB
cord-017527-ylng1us2	304	26	well	well	RB
cord-017527-ylng1us2	304	27	.	.	.
cord-017527-ylng1us2	305	1	Before	before	IN
cord-017527-ylng1us2	305	2	starting	start	VBG
cord-017527-ylng1us2	305	3	any	any	DT
cord-017527-ylng1us2	305	4	of	of	IN
cord-017527-ylng1us2	305	5	such	such	JJ
cord-017527-ylng1us2	305	6	activities	activity	NNS
cord-017527-ylng1us2	305	7	biosafety	biosafety	NN
cord-017527-ylng1us2	305	8	considerations	consideration	NNS
cord-017527-ylng1us2	305	9	should	should	MD
cord-017527-ylng1us2	305	10	be	be	VB
cord-017527-ylng1us2	305	11	addressed	address	VBN
cord-017527-ylng1us2	305	12	by	by	IN
cord-017527-ylng1us2	305	13	performing	perform	VBG
cord-017527-ylng1us2	305	14	a	a	DT
cord-017527-ylng1us2	305	15	biological	biological	JJ
cord-017527-ylng1us2	305	16	risk	risk	NN
cord-017527-ylng1us2	305	17	assessment	assessment	NN
cord-017527-ylng1us2	305	18	allowing	allow	VBG
cord-017527-ylng1us2	305	19	the	the	DT
cord-017527-ylng1us2	305	20	identification	identification	NN
cord-017527-ylng1us2	305	21	and	and	CC
cord-017527-ylng1us2	305	22	characterisation	characterisation	NN
cord-017527-ylng1us2	305	23	of	of	IN
cord-017527-ylng1us2	305	24	any	any	DT
cord-017527-ylng1us2	305	25	potential	potential	JJ
cord-017527-ylng1us2	305	26	adverse	adverse	JJ
cord-017527-ylng1us2	305	27	effect	effect	NN
cord-017527-ylng1us2	305	28	together	together	RB
cord-017527-ylng1us2	305	29	with	with	IN
cord-017527-ylng1us2	305	30	an	an	DT
cord-017527-ylng1us2	305	31	evaluation	evaluation	NN
cord-017527-ylng1us2	305	32	of	of	IN
cord-017527-ylng1us2	305	33	the	the	DT
cord-017527-ylng1us2	305	34	likelihood	likelihood	NN
cord-017527-ylng1us2	305	35	and	and	CC
cord-017527-ylng1us2	305	36	consequences	consequence	NNS
cord-017527-ylng1us2	305	37	should	should	MD
cord-017527-ylng1us2	305	38	any	any	DT
cord-017527-ylng1us2	305	39	effect	effect	NN
cord-017527-ylng1us2	305	40	happen	happen	VB
cord-017527-ylng1us2	305	41	.	.	.
cord-017527-ylng1us2	306	1	Such	such	JJ
cord-017527-ylng1us2	306	2	an	an	DT
cord-017527-ylng1us2	306	3	approach	approach	NN
cord-017527-ylng1us2	306	4	is	be	VBZ
cord-017527-ylng1us2	306	5	made	make	VBN
cord-017527-ylng1us2	306	6	on	on	IN
cord-017527-ylng1us2	306	7	a	a	DT
cord-017527-ylng1us2	306	8	case	case	NN
cord-017527-ylng1us2	306	9	-	-	HYPH
cord-017527-ylng1us2	306	10	by	by	IN
cord-017527-ylng1us2	306	11	-	-	HYPH
cord-017527-ylng1us2	306	12	case	case	NN
cord-017527-ylng1us2	306	13	basis	basis	NN
cord-017527-ylng1us2	306	14	,	,	,
cord-017527-ylng1us2	306	15	taking	take	VBG
cord-017527-ylng1us2	306	16	into	into	IN
cord-017527-ylng1us2	306	17	account	account	NN
cord-017527-ylng1us2	306	18	the	the	DT
cord-017527-ylng1us2	306	19	type	type	NN
cord-017527-ylng1us2	306	20	of	of	IN
cord-017527-ylng1us2	306	21	manipulation	manipulation	NN
cord-017527-ylng1us2	306	22	and	and	CC
cord-017527-ylng1us2	306	23	the	the	DT
cord-017527-ylng1us2	306	24	type	type	NN
cord-017527-ylng1us2	306	25	of	of	IN
cord-017527-ylng1us2	306	26	cell	cell	NN
cord-017527-ylng1us2	306	27	culture	culture	NN
cord-017527-ylng1us2	306	28	handled	handle	VBN
cord-017527-ylng1us2	306	29	.	.	.
cord-017527-ylng1us2	307	1	A	a	DT
cord-017527-ylng1us2	307	2	risk	risk	NN
cord-017527-ylng1us2	307	3	assessment	assessment	NN
cord-017527-ylng1us2	307	4	will	will	MD
cord-017527-ylng1us2	307	5	result	result	VB
cord-017527-ylng1us2	307	6	in	in	IN
cord-017527-ylng1us2	307	7	biosafety	biosafety	NN
cord-017527-ylng1us2	307	8	recommendations	recommendation	NNS
cord-017527-ylng1us2	307	9	in	in	IN
cord-017527-ylng1us2	307	10	view	view	NN
cord-017527-ylng1us2	307	11	of	of	IN
cord-017527-ylng1us2	307	12	the	the	DT
cord-017527-ylng1us2	307	13	implementation	implementation	NN
cord-017527-ylng1us2	307	14	of	of	IN
cord-017527-ylng1us2	307	15	an	an	DT
cord-017527-ylng1us2	307	16	adequate	adequate	JJ
cord-017527-ylng1us2	307	17	containment	containment	NN
cord-017527-ylng1us2	307	18	level	level	NN
cord-017527-ylng1us2	307	19	.	.	.
cord-017527-ylng1us2	308	1	Considering	consider	VBG
cord-017527-ylng1us2	308	2	the	the	DT
cord-017527-ylng1us2	308	3	very	very	RB
cord-017527-ylng1us2	308	4	limited	limited	JJ
cord-017527-ylng1us2	308	5	persistence	persistence	NN
cord-017527-ylng1us2	308	6	capacity	capacity	NN
cord-017527-ylng1us2	308	7	of	of	IN
cord-017527-ylng1us2	308	8	animal	animal	NN
cord-017527-ylng1us2	308	9	and	and	CC
cord-017527-ylng1us2	308	10	human	human	JJ
cord-017527-ylng1us2	308	11	cells	cell	NNS
cord-017527-ylng1us2	308	12	outside	outside	IN
cord-017527-ylng1us2	308	13	non	non	JJ
cord-017527-ylng1us2	308	14	-	-	JJ
cord-017527-ylng1us2	308	15	optimised	optimised	JJ
cord-017527-ylng1us2	308	16	culture	culture	NN
cord-017527-ylng1us2	308	17	conditions	condition	NNS
cord-017527-ylng1us2	308	18	and	and	CC
cord-017527-ylng1us2	308	19	the	the	DT
cord-017527-ylng1us2	308	20	fact	fact	NN
cord-017527-ylng1us2	308	21	that	that	IN
cord-017527-ylng1us2	308	22	many	many	JJ
cord-017527-ylng1us2	308	23	cell	cell	NN
cord-017527-ylng1us2	308	24	lines	line	NNS
cord-017527-ylng1us2	308	25	have	have	VBP
cord-017527-ylng1us2	308	26	a	a	DT
cord-017527-ylng1us2	308	27	long	long	JJ
cord-017527-ylng1us2	308	28	history	history	NN
cord-017527-ylng1us2	308	29	of	of	IN
cord-017527-ylng1us2	308	30	safe	safe	JJ
cord-017527-ylng1us2	308	31	use	use	NN
cord-017527-ylng1us2	308	32	,	,	,
cord-017527-ylng1us2	308	33	it	-PRON-	PRP
cord-017527-ylng1us2	308	34	is	be	VBZ
cord-017527-ylng1us2	308	35	generally	generally	RB
cord-017527-ylng1us2	308	36	considered	consider	VBN
cord-017527-ylng1us2	308	37	unlikely	unlikely	JJ
cord-017527-ylng1us2	308	38	that	that	IN
cord-017527-ylng1us2	308	39	cell	cell	NN
cord-017527-ylng1us2	308	40	cultures	culture	NNS
cord-017527-ylng1us2	308	41	may	may	MD
cord-017527-ylng1us2	308	42	inherently	inherently	RB
cord-017527-ylng1us2	308	43	cause	cause	VB
cord-017527-ylng1us2	308	44	harm	harm	NN
cord-017527-ylng1us2	308	45	to	to	IN
cord-017527-ylng1us2	308	46	humans	human	NNS
cord-017527-ylng1us2	308	47	or	or	CC
cord-017527-ylng1us2	308	48	the	the	DT
cord-017527-ylng1us2	308	49	environment	environment	NN
cord-017527-ylng1us2	308	50	.	.	.
cord-017527-ylng1us2	309	1	The	the	DT
cord-017527-ylng1us2	309	2	main	main	JJ
cord-017527-ylng1us2	309	3	hazard	hazard	NN
cord-017527-ylng1us2	309	4	associated	associate	VBN
cord-017527-ylng1us2	309	5	with	with	IN
cord-017527-ylng1us2	309	6	the	the	DT
cord-017527-ylng1us2	309	7	handling	handling	NN
cord-017527-ylng1us2	309	8	of	of	IN
cord-017527-ylng1us2	309	9	animal	animal	NN
cord-017527-ylng1us2	309	10	cell	cell	NN
cord-017527-ylng1us2	309	11	cultures	culture	NNS
cord-017527-ylng1us2	309	12	resides	reside	VBZ
cord-017527-ylng1us2	309	13	in	in	IN
cord-017527-ylng1us2	309	14	the	the	DT
cord-017527-ylng1us2	309	15	presence	presence	NN
cord-017527-ylng1us2	309	16	of	of	IN
cord-017527-ylng1us2	309	17	adventitious	adventitious	JJ
cord-017527-ylng1us2	309	18	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	309	19	micro	micro	NNS
cord-017527-ylng1us2	309	20	-	-	HYPH
cord-017527-ylng1us2	309	21	organisms	organism	NNS
cord-017527-ylng1us2	309	22	,	,	,
cord-017527-ylng1us2	309	23	which	which	WDT
cord-017527-ylng1us2	309	24	are	be	VBP
cord-017527-ylng1us2	309	25	often	often	RB
cord-017527-ylng1us2	309	26	difficult	difficult	JJ
cord-017527-ylng1us2	309	27	to	to	TO
cord-017527-ylng1us2	309	28	detect	detect	VB
cord-017527-ylng1us2	309	29	and	and	CC
cord-017527-ylng1us2	309	30	hence	hence	RB
cord-017527-ylng1us2	309	31	less	less	RBR
cord-017527-ylng1us2	309	32	controllable	controllable	JJ
cord-017527-ylng1us2	309	33	.	.	.
cord-017527-ylng1us2	310	1	In	in	IN
cord-017527-ylng1us2	310	2	contrast	contrast	NN
cord-017527-ylng1us2	310	3	to	to	IN
cord-017527-ylng1us2	310	4	their	-PRON-	PRP$
cord-017527-ylng1us2	310	5	host	host	NN
cord-017527-ylng1us2	310	6	cells	cell	NNS
cord-017527-ylng1us2	310	7	,	,	,
cord-017527-ylng1us2	310	8	adventitious	adventitious	JJ
cord-017527-ylng1us2	310	9	organisms	organism	NNS
cord-017527-ylng1us2	310	10	can	can	MD
cord-017527-ylng1us2	310	11	persist	persist	VB
cord-017527-ylng1us2	310	12	in	in	IN
cord-017527-ylng1us2	310	13	more	more	JJR
cord-017527-ylng1us2	310	14	hostile	hostile	JJ
cord-017527-ylng1us2	310	15	conditions	condition	NNS
cord-017527-ylng1us2	310	16	and	and	CC
cord-017527-ylng1us2	310	17	may	may	MD
cord-017527-ylng1us2	310	18	present	present	VB
cord-017527-ylng1us2	310	19	risks	risk	NNS
cord-017527-ylng1us2	310	20	for	for	IN
cord-017527-ylng1us2	310	21	human	human	JJ
cord-017527-ylng1us2	310	22	health	health	NN
cord-017527-ylng1us2	310	23	or	or	CC
cord-017527-ylng1us2	310	24	the	the	DT
cord-017527-ylng1us2	310	25	environment	environment	NN
cord-017527-ylng1us2	310	26	in	in	IN
cord-017527-ylng1us2	310	27	case	case	NN
cord-017527-ylng1us2	310	28	they	-PRON-	PRP
cord-017527-ylng1us2	310	29	are	be	VBP
cord-017527-ylng1us2	310	30	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	310	31	(	(	-LRB-
cord-017527-ylng1us2	310	32	Bean	Bean	NNP
cord-017527-ylng1us2	310	33	et	et	FW
cord-017527-ylng1us2	310	34	al	al	NNP
cord-017527-ylng1us2	310	35	.	.	.
cord-017527-ylng1us2	310	36	1982	1982	CD
cord-017527-ylng1us2	311	1	;	;	:
cord-017527-ylng1us2	311	2	Walther	Walther	NNP
cord-017527-ylng1us2	311	3	and	and	CC
cord-017527-ylng1us2	311	4	Ewald	Ewald	NNP
cord-017527-ylng1us2	311	5	2004	2004	CD
cord-017527-ylng1us2	311	6	;	;	:
cord-017527-ylng1us2	311	7	Kallio	Kallio	NNP
cord-017527-ylng1us2	311	8	et	et	FW
cord-017527-ylng1us2	311	9	al	al	NNP
cord-017527-ylng1us2	311	10	.	.	.
cord-017527-ylng1us2	312	1	2006	2006	CD
cord-017527-ylng1us2	312	2	;	;	:
cord-017527-ylng1us2	312	3	Kramer	Kramer	NNP
cord-017527-ylng1us2	312	4	et	et	NNP
cord-017527-ylng1us2	312	5	al	al	NNP
cord-017527-ylng1us2	312	6	.	.	.
cord-017527-ylng1us2	312	7	2006	2006	CD
cord-017527-ylng1us2	312	8	)	)	-RRB-
cord-017527-ylng1us2	312	9	.	.	.
cord-017527-ylng1us2	313	1	For	for	IN
cord-017527-ylng1us2	313	2	this	this	DT
cord-017527-ylng1us2	313	3	reason	reason	NN
cord-017527-ylng1us2	313	4	,	,	,
cord-017527-ylng1us2	313	5	a	a	DT
cord-017527-ylng1us2	313	6	risk	risk	NN
cord-017527-ylng1us2	313	7	assessment	assessment	NN
cord-017527-ylng1us2	313	8	of	of	IN
cord-017527-ylng1us2	313	9	cell	cell	NN
cord-017527-ylng1us2	313	10	cultures	culture	NNS
cord-017527-ylng1us2	313	11	will	will	MD
cord-017527-ylng1us2	313	12	frequently	frequently	RB
cord-017527-ylng1us2	313	13	lead	lead	VB
cord-017527-ylng1us2	313	14	to	to	IN
cord-017527-ylng1us2	313	15	a	a	DT
cord-017527-ylng1us2	313	16	risk	risk	NN
cord-017527-ylng1us2	313	17	assessment	assessment	NN
cord-017527-ylng1us2	313	18	of	of	IN
cord-017527-ylng1us2	313	19	the	the	DT
cord-017527-ylng1us2	313	20	potential	potential	JJ
cord-017527-ylng1us2	313	21	adventitious	adventitious	JJ
cord-017527-ylng1us2	313	22	contaminants	contaminant	NNS
cord-017527-ylng1us2	313	23	,	,	,
cord-017527-ylng1us2	313	24	the	the	DT
cord-017527-ylng1us2	313	25	organisms	organism	NNS
cord-017527-ylng1us2	313	26	used	use	VBD
cord-017527-ylng1us2	313	27	for	for	IN
cord-017527-ylng1us2	313	28	cell	cell	NN
cord-017527-ylng1us2	313	29	's	's	POS
cord-017527-ylng1us2	313	30	immortalisation	immortalisation	NN
cord-017527-ylng1us2	313	31	(	(	-LRB-
cord-017527-ylng1us2	313	32	viruses	virus	NNS
cord-017527-ylng1us2	313	33	,	,	,
cord-017527-ylng1us2	313	34	viral	viral	JJ
cord-017527-ylng1us2	313	35	sequences	sequence	NNS
cord-017527-ylng1us2	313	36	,	,	,
cord-017527-ylng1us2	313	37	etc	etc	FW
cord-017527-ylng1us2	313	38	.	.	.
cord-017527-ylng1us2	313	39	)	)	-RRB-
cord-017527-ylng1us2	314	1	and/or	and/or	CC
cord-017527-ylng1us2	314	2	the	the	DT
cord-017527-ylng1us2	314	3	microorganisms	microorganism	NNS
cord-017527-ylng1us2	314	4	intentionally	intentionally	RB
cord-017527-ylng1us2	314	5	used	use	VBN
cord-017527-ylng1us2	314	6	to	to	TO
cord-017527-ylng1us2	314	7	experimentally	experimentally	RB
cord-017527-ylng1us2	314	8	infect	infect	VB
cord-017527-ylng1us2	314	9	them	-PRON-	PRP
cord-017527-ylng1us2	314	10	.	.	.
cord-017527-ylng1us2	315	1	Though	though	IN
cord-017527-ylng1us2	315	2	the	the	DT
cord-017527-ylng1us2	315	3	assignment	assignment	NN
cord-017527-ylng1us2	315	4	of	of	IN
cord-017527-ylng1us2	315	5	biosafety	biosafety	NN
cord-017527-ylng1us2	315	6	containment	containment	NN
cord-017527-ylng1us2	315	7	level	level	NN
cord-017527-ylng1us2	315	8	requirements	requirement	NNS
cord-017527-ylng1us2	315	9	can	can	MD
cord-017527-ylng1us2	315	10	not	not	RB
cord-017527-ylng1us2	315	11	be	be	VB
cord-017527-ylng1us2	315	12	generalised	generalise	VBN
cord-017527-ylng1us2	315	13	and	and	CC
cord-017527-ylng1us2	315	14	should	should	MD
cord-017527-ylng1us2	315	15	be	be	VB
cord-017527-ylng1us2	315	16	performed	perform	VBN
cord-017527-ylng1us2	315	17	on	on	IN
cord-017527-ylng1us2	315	18	a	a	DT
cord-017527-ylng1us2	315	19	case	case	NN
cord-017527-ylng1us2	315	20	-	-	HYPH
cord-017527-ylng1us2	315	21	by	by	IN
cord-017527-ylng1us2	315	22	-	-	HYPH
cord-017527-ylng1us2	315	23	case	case	NN
cord-017527-ylng1us2	315	24	basis	basis	NN
cord-017527-ylng1us2	315	25	,	,	,
cord-017527-ylng1us2	315	26	it	-PRON-	PRP
cord-017527-ylng1us2	315	27	is	be	VBZ
cord-017527-ylng1us2	315	28	recognised	recognise	VBN
cord-017527-ylng1us2	315	29	that	that	IN
cord-017527-ylng1us2	315	30	most	most	JJS
cord-017527-ylng1us2	315	31	of	of	IN
cord-017527-ylng1us2	315	32	the	the	DT
cord-017527-ylng1us2	315	33	containment	containment	NN
cord-017527-ylng1us2	315	34	measures	measure	NNS
cord-017527-ylng1us2	315	35	primarily	primarily	RB
cord-017527-ylng1us2	315	36	aim	aim	VBP
cord-017527-ylng1us2	315	37	at	at	IN
cord-017527-ylng1us2	315	38	protecting	protect	VBG
cord-017527-ylng1us2	315	39	cells	cell	NNS
cord-017527-ylng1us2	315	40	from	from	IN
cord-017527-ylng1us2	315	41	adventitious	adventitious	JJ
cord-017527-ylng1us2	315	42	contamination	contamination	NN
cord-017527-ylng1us2	315	43	in	in	IN
cord-017527-ylng1us2	315	44	order	order	NN
cord-017527-ylng1us2	315	45	to	to	TO
cord-017527-ylng1us2	315	46	mitigate	mitigate	VB
cord-017527-ylng1us2	315	47	potential	potential	JJ
cord-017527-ylng1us2	315	48	risks	risk	NNS
cord-017527-ylng1us2	315	49	for	for	IN
cord-017527-ylng1us2	315	50	the	the	DT
cord-017527-ylng1us2	315	51	laboratory	laboratory	NN
cord-017527-ylng1us2	315	52	worker	worker	NN
cord-017527-ylng1us2	315	53	.	.	.
cord-017527-ylng1us2	316	1	Except	except	IN
cord-017527-ylng1us2	316	2	for	for	IN
cord-017527-ylng1us2	316	3	authenticated	authenticated	JJ
cord-017527-ylng1us2	316	4	cell	cell	NN
cord-017527-ylng1us2	316	5	lines	line	NNS
cord-017527-ylng1us2	316	6	proved	prove	VBD
cord-017527-ylng1us2	316	7	to	to	TO
cord-017527-ylng1us2	316	8	present	present	VB
cord-017527-ylng1us2	316	9	no	no	DT
cord-017527-ylng1us2	316	10	risk	risk	NN
cord-017527-ylng1us2	316	11	,	,	,
cord-017527-ylng1us2	316	12	the	the	DT
cord-017527-ylng1us2	316	13	activities	activity	NNS
cord-017527-ylng1us2	316	14	involving	involve	VBG
cord-017527-ylng1us2	316	15	cell	cell	NN
cord-017527-ylng1us2	316	16	cultures	culture	NNS
cord-017527-ylng1us2	316	17	from	from	IN
cord-017527-ylng1us2	316	18	human	human	JJ
cord-017527-ylng1us2	316	19	or	or	CC
cord-017527-ylng1us2	316	20	primate	primate	JJ
cord-017527-ylng1us2	316	21	origin	origin	NN
cord-017527-ylng1us2	316	22	should	should	MD
cord-017527-ylng1us2	316	23	generally	generally	RB
cord-017527-ylng1us2	316	24	be	be	VB
cord-017527-ylng1us2	316	25	performed	perform	VBN
cord-017527-ylng1us2	316	26	under	under	IN
cord-017527-ylng1us2	316	27	containment	containment	NN
cord-017527-ylng1us2	316	28	level	level	NN
cord-017527-ylng1us2	316	29	2	2	CD
cord-017527-ylng1us2	316	30	involving	involve	VBG
cord-017527-ylng1us2	316	31	the	the	DT
cord-017527-ylng1us2	316	32	use	use	NN
cord-017527-ylng1us2	316	33	of	of	IN
cord-017527-ylng1us2	316	34	a	a	DT
cord-017527-ylng1us2	316	35	class	class	NN
cord-017527-ylng1us2	316	36	II	II	NNP
cord-017527-ylng1us2	316	37	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	316	38	cabinet	cabinet	NN
cord-017527-ylng1us2	316	39	and	and	CC
cord-017527-ylng1us2	316	40	Good	Good	NNP
cord-017527-ylng1us2	316	41	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	316	42	Practice	Practice	NNP
cord-017527-ylng1us2	316	43	.	.	.
cord-017527-ylng1us2	317	1	Whilst	whilst	IN
cord-017527-ylng1us2	317	2	the	the	DT
cord-017527-ylng1us2	317	3	occurrence	occurrence	NN
cord-017527-ylng1us2	317	4	of	of	IN
cord-017527-ylng1us2	317	5	adverse	adverse	JJ
cord-017527-ylng1us2	317	6	effects	effect	NNS
cord-017527-ylng1us2	317	7	related	relate	VBN
cord-017527-ylng1us2	317	8	to	to	IN
cord-017527-ylng1us2	317	9	the	the	DT
cord-017527-ylng1us2	317	10	handling	handling	NN
cord-017527-ylng1us2	317	11	of	of	IN
cord-017527-ylng1us2	317	12	cell	cell	NN
cord-017527-ylng1us2	317	13	cultures	culture	NNS
cord-017527-ylng1us2	317	14	can	can	MD
cord-017527-ylng1us2	317	15	not	not	RB
cord-017527-ylng1us2	317	16	be	be	VB
cord-017527-ylng1us2	317	17	excluded	exclude	VBN
cord-017527-ylng1us2	317	18	,	,	,
cord-017527-ylng1us2	317	19	a	a	DT
cord-017527-ylng1us2	317	20	thorough	thorough	JJ
cord-017527-ylng1us2	317	21	risk	risk	NN
cord-017527-ylng1us2	317	22	assessment	assessment	NN
cord-017527-ylng1us2	317	23	and	and	CC
cord-017527-ylng1us2	317	24	the	the	DT
cord-017527-ylng1us2	317	25	implementation	implementation	NN
cord-017527-ylng1us2	317	26	of	of	IN
cord-017527-ylng1us2	317	27	the	the	DT
cord-017527-ylng1us2	317	28	appropriate	appropriate	JJ
cord-017527-ylng1us2	317	29	containment	containment	NN
cord-017527-ylng1us2	317	30	level	level	NN
cord-017527-ylng1us2	317	31	offer	offer	VBP
cord-017527-ylng1us2	317	32	an	an	DT
cord-017527-ylng1us2	317	33	optimal	optimal	JJ
cord-017527-ylng1us2	317	34	protection	protection	NN
cord-017527-ylng1us2	317	35	for	for	IN
cord-017527-ylng1us2	317	36	the	the	DT
cord-017527-ylng1us2	317	37	laboratory	laboratory	NN
cord-017527-ylng1us2	317	38	worker	worker	NN
cord-017527-ylng1us2	317	39	and	and	CC
cord-017527-ylng1us2	317	40	by	by	IN
cord-017527-ylng1us2	317	41	extension	extension	NN
cord-017527-ylng1us2	317	42	,	,	,
cord-017527-ylng1us2	317	43	public	public	JJ
cord-017527-ylng1us2	317	44	health	health	NN
cord-017527-ylng1us2	317	45	and	and	CC
cord-017527-ylng1us2	317	46	the	the	DT
cord-017527-ylng1us2	317	47	environment	environment	NN
cord-017527-ylng1us2	317	48	.	.	.
cord-017527-ylng1us2	318	1	Continuous	continuous	JJ
cord-017527-ylng1us2	318	2	efforts	effort	NNS
cord-017527-ylng1us2	318	3	have	have	VBP
cord-017527-ylng1us2	318	4	been	be	VBN
cord-017527-ylng1us2	318	5	made	make	VBN
cord-017527-ylng1us2	318	6	to	to	TO
cord-017527-ylng1us2	318	7	mitigate	mitigate	VB
cord-017527-ylng1us2	318	8	the	the	DT
cord-017527-ylng1us2	318	9	risk	risk	NN
cord-017527-ylng1us2	318	10	associated	associate	VBN
cord-017527-ylng1us2	318	11	with	with	IN
cord-017527-ylng1us2	318	12	the	the	DT
cord-017527-ylng1us2	318	13	handling	handling	NN
cord-017527-ylng1us2	318	14	of	of	IN
cord-017527-ylng1us2	318	15	cell	cell	NN
cord-017527-ylng1us2	318	16	culture	culture	NN
cord-017527-ylng1us2	318	17	in	in	IN
cord-017527-ylng1us2	318	18	laboratory	laboratory	NN
cord-017527-ylng1us2	318	19	settings	setting	NNS
cord-017527-ylng1us2	318	20	.	.	.
cord-017527-ylng1us2	319	1	These	these	DT
cord-017527-ylng1us2	319	2	biorisk	biorisk	NNP
cord-017527-ylng1us2	319	3	management	management	NN
cord-017527-ylng1us2	319	4	(	(	-LRB-
cord-017527-ylng1us2	319	5	continued	continue	VBN
cord-017527-ylng1us2	319	6	)	)	-RRB-
cord-017527-ylng1us2	319	7	measures	measure	NNS
cord-017527-ylng1us2	319	8	(	(	-LRB-
cord-017527-ylng1us2	319	9	i.e.	i.e.	FW
cord-017527-ylng1us2	319	10	adoption	adoption	NN
cord-017527-ylng1us2	319	11	of	of	IN
cord-017527-ylng1us2	319	12	the	the	DT
cord-017527-ylng1us2	319	13	appropriate	appropriate	JJ
cord-017527-ylng1us2	319	14	containment	containment	NN
cord-017527-ylng1us2	319	15	level	level	NN
cord-017527-ylng1us2	319	16	)	)	-RRB-
cord-017527-ylng1us2	319	17	can	can	MD
cord-017527-ylng1us2	319	18	be	be	VB
cord-017527-ylng1us2	319	19	coupled	couple	VBN
cord-017527-ylng1us2	319	20	with	with	IN
cord-017527-ylng1us2	319	21	the	the	DT
cord-017527-ylng1us2	319	22	implementation	implementation	NN
cord-017527-ylng1us2	319	23	of	of	IN
cord-017527-ylng1us2	319	24	automation	automation	NN
cord-017527-ylng1us2	319	25	platforms	platform	NNS
cord-017527-ylng1us2	319	26	allowing	allow	VBG
cord-017527-ylng1us2	319	27	the	the	DT
cord-017527-ylng1us2	319	28	reduction	reduction	NN
cord-017527-ylng1us2	319	29	of	of	IN
cord-017527-ylng1us2	319	30	cell	cell	NN
cord-017527-ylng1us2	319	31	culture	culture	NN
cord-017527-ylng1us2	319	32	cross	cross	NN
cord-017527-ylng1us2	319	33	-	-	NN
cord-017527-ylng1us2	319	34	contamination	contamination	NN
cord-017527-ylng1us2	319	35	and	and	CC
cord-017527-ylng1us2	319	36	accidental	accidental	JJ
cord-017527-ylng1us2	319	37	contamination	contamination	NN
cord-017527-ylng1us2	319	38	with	with	IN
cord-017527-ylng1us2	319	39	infectious	infectious	JJ
cord-017527-ylng1us2	319	40	agents	agent	NNS
cord-017527-ylng1us2	319	41	.	.	.
cord-017527-ylng1us2	320	1	It	-PRON-	PRP
cord-017527-ylng1us2	320	2	is	be	VBZ
cord-017527-ylng1us2	320	3	anticipated	anticipate	VBN
cord-017527-ylng1us2	320	4	that	that	IN
cord-017527-ylng1us2	320	5	future	future	JJ
cord-017527-ylng1us2	320	6	efforts	effort	NNS
cord-017527-ylng1us2	320	7	contributing	contribute	VBG
cord-017527-ylng1us2	320	8	to	to	IN
cord-017527-ylng1us2	320	9	the	the	DT
cord-017527-ylng1us2	320	10	improvement	improvement	NN
cord-017527-ylng1us2	320	11	of	of	IN
cord-017527-ylng1us2	320	12	the	the	DT
cord-017527-ylng1us2	320	13	quality	quality	NN
cord-017527-ylng1us2	320	14	of	of	IN
cord-017527-ylng1us2	320	15	the	the	DT
cord-017527-ylng1us2	320	16	data	datum	NNS
cord-017527-ylng1us2	320	17	necessary	necessary	JJ
cord-017527-ylng1us2	320	18	for	for	IN
cord-017527-ylng1us2	320	19	the	the	DT
cord-017527-ylng1us2	320	20	risk	risk	NN
cord-017527-ylng1us2	320	21	assessment	assessment	NN
cord-017527-ylng1us2	320	22	,	,	,
cord-017527-ylng1us2	320	23	the	the	DT
cord-017527-ylng1us2	320	24	containment	containment	NN
cord-017527-ylng1us2	320	25	measures	measure	NNS
cord-017527-ylng1us2	320	26	and	and	CC
cord-017527-ylng1us2	320	27	the	the	DT
cord-017527-ylng1us2	320	28	increased	increase	VBN
cord-017527-ylng1us2	320	29	awareness	awareness	NN
cord-017527-ylng1us2	320	30	of	of	IN
cord-017527-ylng1us2	320	31	biosafety	biosafety	NN
cord-017527-ylng1us2	320	32	considerations	consideration	NNS
cord-017527-ylng1us2	320	33	within	within	IN
cord-017527-ylng1us2	320	34	the	the	DT
cord-017527-ylng1us2	320	35	scientific	scientific	JJ
cord-017527-ylng1us2	320	36	community	community	NN
cord-017527-ylng1us2	320	37	will	will	MD
cord-017527-ylng1us2	320	38	also	also	RB
cord-017527-ylng1us2	320	39	directly	directly	RB
cord-017527-ylng1us2	320	40	benefit	benefit	VB
cord-017527-ylng1us2	320	41	the	the	DT
cord-017527-ylng1us2	320	42	quality	quality	NN
cord-017527-ylng1us2	320	43	of	of	IN
cord-017527-ylng1us2	320	44	research	research	NN
cord-017527-ylng1us2	320	45	activities	activity	NNS
cord-017527-ylng1us2	320	46	involving	involve	VBG
cord-017527-ylng1us2	320	47	animal	animal	NN
cord-017527-ylng1us2	320	48	cell	cell	NN
cord-017527-ylng1us2	320	49	cultures	culture	NNS
cord-017527-ylng1us2	320	50	.	.	.
cord-017527-ylng1us2	321	1	Authentication	authentication	NN
cord-017527-ylng1us2	321	2	Is	be	VBZ
cord-017527-ylng1us2	321	3	the	the	DT
cord-017527-ylng1us2	321	4	process	process	NN
cord-017527-ylng1us2	321	5	by	by	IN
cord-017527-ylng1us2	321	6	which	which	WDT
cord-017527-ylng1us2	321	7	the	the	DT
cord-017527-ylng1us2	321	8	true	true	JJ
cord-017527-ylng1us2	321	9	origin	origin	NN
cord-017527-ylng1us2	321	10	and	and	CC
cord-017527-ylng1us2	321	11	identity	identity	NN
cord-017527-ylng1us2	321	12	of	of	IN
cord-017527-ylng1us2	321	13	cell	cell	NN
cord-017527-ylng1us2	321	14	lines	line	NNS
cord-017527-ylng1us2	321	15	are	be	VBP
cord-017527-ylng1us2	321	16	determined	determined	JJ
cord-017527-ylng1us2	321	17	and	and	CC
cord-017527-ylng1us2	321	18	should	should	MD
cord-017527-ylng1us2	321	19	form	form	VB
cord-017527-ylng1us2	321	20	an	an	DT
cord-017527-ylng1us2	321	21	essential	essential	JJ
cord-017527-ylng1us2	321	22	part	part	NN
cord-017527-ylng1us2	321	23	of	of	IN
cord-017527-ylng1us2	321	24	any	any	DT
cord-017527-ylng1us2	321	25	cell	cell	NN
cord-017527-ylng1us2	321	26	culture	culture	NN
cord-017527-ylng1us2	321	27	operation	operation	NN
cord-017527-ylng1us2	321	28	.	.	.
cord-017527-ylng1us2	322	1	Biosafety	biosafety	NN
cord-017527-ylng1us2	323	1	In	in	IN
cord-017527-ylng1us2	323	2	the	the	DT
cord-017527-ylng1us2	323	3	context	context	NN
cord-017527-ylng1us2	323	4	of	of	IN
cord-017527-ylng1us2	323	5	this	this	DT
cord-017527-ylng1us2	323	6	chapter	chapter	NN
cord-017527-ylng1us2	323	7	,	,	,
cord-017527-ylng1us2	323	8	biosafety	biosafety	NN
cord-017527-ylng1us2	323	9	relates	relate	VBZ
cord-017527-ylng1us2	323	10	to	to	IN
cord-017527-ylng1us2	323	11	the	the	DT
cord-017527-ylng1us2	323	12	evaluation	evaluation	NN
cord-017527-ylng1us2	323	13	of	of	IN
cord-017527-ylng1us2	323	14	the	the	DT
cord-017527-ylng1us2	323	15	potential	potential	JJ
cord-017527-ylng1us2	323	16	risks	risk	NNS
cord-017527-ylng1us2	323	17	to	to	IN
cord-017527-ylng1us2	323	18	human	human	JJ
cord-017527-ylng1us2	323	19	health	health	NN
cord-017527-ylng1us2	323	20	and	and	CC
cord-017527-ylng1us2	323	21	the	the	DT
cord-017527-ylng1us2	323	22	environment	environment	NN
cord-017527-ylng1us2	323	23	associated	associate	VBN
cord-017527-ylng1us2	323	24	with	with	IN
cord-017527-ylng1us2	323	25	the	the	DT
cord-017527-ylng1us2	323	26	use	use	NN
cord-017527-ylng1us2	323	27	of	of	IN
cord-017527-ylng1us2	323	28	genetically	genetically	RB
cord-017527-ylng1us2	323	29	modified	modify	VBN
cord-017527-ylng1us2	323	30	organisms	organism	NNS
cord-017527-ylng1us2	323	31	(	(	-LRB-
cord-017527-ylng1us2	323	32	GMOs	GMOs	NNP
cord-017527-ylng1us2	323	33	)	)	-RRB-
cord-017527-ylng1us2	323	34	or	or	CC
cord-017527-ylng1us2	323	35	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	323	36	organisms	organism	NNS
cord-017527-ylng1us2	323	37	.	.	.
cord-017527-ylng1us2	324	1	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	324	2	Cabinet	Cabinet	NNP
cord-017527-ylng1us2	324	3	(	(	-LRB-
cord-017527-ylng1us2	324	4	Class	Class	NNP
cord-017527-ylng1us2	324	5	II	II	NNP
cord-017527-ylng1us2	324	6	)	)	-RRB-
cord-017527-ylng1us2	325	1	Safety	safety	NN
cord-017527-ylng1us2	325	2	cabinet	cabinet	NN
cord-017527-ylng1us2	325	3	with	with	IN
cord-017527-ylng1us2	325	4	a	a	DT
cord-017527-ylng1us2	325	5	front	front	JJ
cord-017527-ylng1us2	325	6	aperture	aperture	NN
cord-017527-ylng1us2	325	7	through	through	IN
cord-017527-ylng1us2	325	8	which	which	WDT
cord-017527-ylng1us2	325	9	the	the	DT
cord-017527-ylng1us2	325	10	operator	operator	NN
cord-017527-ylng1us2	325	11	can	can	MD
cord-017527-ylng1us2	325	12	carry	carry	VB
cord-017527-ylng1us2	325	13	out	out	RP
cord-017527-ylng1us2	325	14	manipulations	manipulation	NNS
cord-017527-ylng1us2	325	15	inside	inside	IN
cord-017527-ylng1us2	325	16	the	the	DT
cord-017527-ylng1us2	325	17	cabinet	cabinet	NN
cord-017527-ylng1us2	325	18	and	and	CC
cord-017527-ylng1us2	325	19	which	which	WDT
cord-017527-ylng1us2	325	20	is	be	VBZ
cord-017527-ylng1us2	325	21	constructed	construct	VBN
cord-017527-ylng1us2	325	22	so	so	IN
cord-017527-ylng1us2	325	23	that	that	IN
cord-017527-ylng1us2	325	24	the	the	DT
cord-017527-ylng1us2	325	25	laboratory	laboratory	NN
cord-017527-ylng1us2	325	26	worker	worker	NN
cord-017527-ylng1us2	325	27	is	be	VBZ
cord-017527-ylng1us2	325	28	protected	protect	VBN
cord-017527-ylng1us2	325	29	,	,	,
cord-017527-ylng1us2	325	30	the	the	DT
cord-017527-ylng1us2	325	31	product	product	NN
cord-017527-ylng1us2	325	32	and	and	CC
cord-017527-ylng1us2	325	33	cross	cross	NN
cord-017527-ylng1us2	325	34	contamination	contamination	NN
cord-017527-ylng1us2	325	35	is	be	VBZ
cord-017527-ylng1us2	325	36	low	low	JJ
cord-017527-ylng1us2	325	37	.	.	.
cord-017527-ylng1us2	326	1	The	the	DT
cord-017527-ylng1us2	326	2	escape	escape	NN
cord-017527-ylng1us2	326	3	of	of	IN
cord-017527-ylng1us2	326	4	airborne	airborne	JJ
cord-017527-ylng1us2	326	5	particulate	particulate	NN
cord-017527-ylng1us2	326	6	contamination	contamination	NN
cord-017527-ylng1us2	326	7	generated	generate	VBN
cord-017527-ylng1us2	326	8	within	within	IN
cord-017527-ylng1us2	326	9	the	the	DT
cord-017527-ylng1us2	326	10	cabinet	cabinet	NN
cord-017527-ylng1us2	326	11	is	be	VBZ
cord-017527-ylng1us2	326	12	controlled	control	VBN
cord-017527-ylng1us2	326	13	by	by	IN
cord-017527-ylng1us2	326	14	means	mean	NNS
cord-017527-ylng1us2	326	15	of	of	IN
cord-017527-ylng1us2	326	16	an	an	DT
cord-017527-ylng1us2	326	17	appropriate	appropriate	JJ
cord-017527-ylng1us2	326	18	filtered	filter	VBN
cord-017527-ylng1us2	326	19	internal	internal	JJ
cord-017527-ylng1us2	326	20	airflow	airflow	NN
cord-017527-ylng1us2	326	21	and	and	CC
cord-017527-ylng1us2	326	22	filtration	filtration	NN
cord-017527-ylng1us2	326	23	of	of	IN
cord-017527-ylng1us2	326	24	the	the	DT
cord-017527-ylng1us2	326	25	exhaust	exhaust	NN
cord-017527-ylng1us2	326	26	air	air	NN
cord-017527-ylng1us2	326	27	(	(	-LRB-
cord-017527-ylng1us2	326	28	HEPA	HEPA	NNP
cord-017527-ylng1us2	326	29	filters	filter	NNS
cord-017527-ylng1us2	326	30	)	)	-RRB-
cord-017527-ylng1us2	326	31	.	.	.
cord-017527-ylng1us2	327	1	Contained	contain	VBN
cord-017527-ylng1us2	327	2	use	use	VBP
cord-017527-ylng1us2	327	3	Any	any	DT
cord-017527-ylng1us2	327	4	activity	activity	NN
cord-017527-ylng1us2	327	5	in	in	IN
cord-017527-ylng1us2	327	6	which	which	WDT
cord-017527-ylng1us2	327	7	(	(	-LRB-
cord-017527-ylng1us2	327	8	micro)-organisms	micro)-organism	NNS
cord-017527-ylng1us2	327	9	are	be	VBP
cord-017527-ylng1us2	327	10	genetically	genetically	RB
cord-017527-ylng1us2	327	11	modified	modify	VBN
cord-017527-ylng1us2	327	12	or	or	CC
cord-017527-ylng1us2	327	13	in	in	IN
cord-017527-ylng1us2	327	14	which	which	WDT
cord-017527-ylng1us2	327	15	such	such	JJ
cord-017527-ylng1us2	327	16	organism	organism	NN
cord-017527-ylng1us2	327	17	(	(	-LRB-
cord-017527-ylng1us2	327	18	pathogenic	pathogenic	JJ
cord-017527-ylng1us2	327	19	or	or	CC
cord-017527-ylng1us2	327	20	not	not	RB
cord-017527-ylng1us2	327	21	)	)	-RRB-
cord-017527-ylng1us2	327	22	are	be	VBP
cord-017527-ylng1us2	327	23	cultured	culture	VBN
cord-017527-ylng1us2	327	24	,	,	,
cord-017527-ylng1us2	327	25	stored	store	VBN
cord-017527-ylng1us2	327	26	,	,	,
cord-017527-ylng1us2	327	27	transported	transport	VBN
cord-017527-ylng1us2	327	28	,	,	,
cord-017527-ylng1us2	327	29	destroyed	destroy	VBN
cord-017527-ylng1us2	327	30	,	,	,
cord-017527-ylng1us2	327	31	disposed	dispose	VBN
cord-017527-ylng1us2	327	32	or	or	CC
cord-017527-ylng1us2	327	33	used	use	VBN
cord-017527-ylng1us2	327	34	in	in	IN
cord-017527-ylng1us2	327	35	any	any	DT
cord-017527-ylng1us2	327	36	other	other	JJ
cord-017527-ylng1us2	327	37	way	way	NN
cord-017527-ylng1us2	327	38	,	,	,
cord-017527-ylng1us2	327	39	and	and	CC
cord-017527-ylng1us2	327	40	for	for	IN
cord-017527-ylng1us2	327	41	which	which	WDT
cord-017527-ylng1us2	327	42	specific	specific	JJ
cord-017527-ylng1us2	327	43	containment	containment	NN
cord-017527-ylng1us2	327	44	measures	measure	NNS
cord-017527-ylng1us2	327	45	are	be	VBP
cord-017527-ylng1us2	327	46	used	use	VBN
cord-017527-ylng1us2	327	47	to	to	TO
cord-017527-ylng1us2	327	48	limit	limit	VB
cord-017527-ylng1us2	327	49	their	-PRON-	PRP$
cord-017527-ylng1us2	327	50	contact	contact	NN
cord-017527-ylng1us2	327	51	with	with	IN
cord-017527-ylng1us2	327	52	the	the	DT
cord-017527-ylng1us2	327	53	general	general	JJ
cord-017527-ylng1us2	327	54	population	population	NN
cord-017527-ylng1us2	327	55	and	and	CC
cord-017527-ylng1us2	327	56	the	the	DT
cord-017527-ylng1us2	327	57	environment	environment	NN
cord-017527-ylng1us2	327	58	.	.	.
cord-017527-ylng1us2	328	1	Culture	culture	NN
cord-017527-ylng1us2	328	2	Type	type	NN
cord-017527-ylng1us2	328	3	:	:	:
cord-017527-ylng1us2	329	1	Primary	primary	JJ
cord-017527-ylng1us2	329	2	Cell	cell	NN
cord-017527-ylng1us2	329	3	Cultures	Cultures	NNPS
cord-017527-ylng1us2	329	4	,	,	,
cord-017527-ylng1us2	329	5	Diploid	Diploid	NNP
cord-017527-ylng1us2	329	6	Cell	Cell	NNP
cord-017527-ylng1us2	329	7	Lines	Lines	NNP
cord-017527-ylng1us2	329	8	,	,	,
cord-017527-ylng1us2	329	9	Continuous	Continuous	NNP
cord-017527-ylng1us2	329	10	Cell	Cell	NNP
cord-017527-ylng1us2	329	11	Lines	Lines	NNP
cord-017527-ylng1us2	329	12	Primary	primary	JJ
cord-017527-ylng1us2	329	13	cell	cell	NN
cord-017527-ylng1us2	329	14	cultures	culture	NNS
cord-017527-ylng1us2	329	15	Are	be	VBP
cord-017527-ylng1us2	329	16	established	establish	VBN
cord-017527-ylng1us2	329	17	directly	directly	RB
cord-017527-ylng1us2	329	18	from	from	IN
cord-017527-ylng1us2	329	19	tissues	tissue	NNS
cord-017527-ylng1us2	329	20	of	of	IN
cord-017527-ylng1us2	329	21	animals	animal	NNS
cord-017527-ylng1us2	329	22	and	and	CC
cord-017527-ylng1us2	329	23	are	be	VBP
cord-017527-ylng1us2	329	24	often	often	RB
cord-017527-ylng1us2	329	25	the	the	DT
cord-017527-ylng1us2	329	26	most	most	RBS
cord-017527-ylng1us2	329	27	appropriate	appropriate	JJ
cord-017527-ylng1us2	329	28	in	in	IN
cord-017527-ylng1us2	329	29	vitro	vitro	FW
cord-017527-ylng1us2	329	30	tool	tool	NN
cord-017527-ylng1us2	329	31	for	for	IN
cord-017527-ylng1us2	329	32	reproducing	reproduce	VBG
cord-017527-ylng1us2	329	33	typical	typical	JJ
cord-017527-ylng1us2	329	34	cellular	cellular	JJ
cord-017527-ylng1us2	329	35	responses	response	NNS
cord-017527-ylng1us2	329	36	observed	observe	VBN
cord-017527-ylng1us2	329	37	in	in	IN
cord-017527-ylng1us2	329	38	vivo	vivo	NNP
cord-017527-ylng1us2	329	39	.	.	.
cord-017527-ylng1us2	330	1	However	however	RB
cord-017527-ylng1us2	330	2	,	,	,
cord-017527-ylng1us2	330	3	as	as	IN
cord-017527-ylng1us2	330	4	typical	typical	JJ
cord-017527-ylng1us2	330	5	cell	cell	NN
cord-017527-ylng1us2	330	6	characteristics	characteristic	NNS
cord-017527-ylng1us2	330	7	are	be	VBP
cord-017527-ylng1us2	330	8	lost	lose	VBN
cord-017527-ylng1us2	330	9	during	during	IN
cord-017527-ylng1us2	330	10	passaging	passaging	NN
cord-017527-ylng1us2	330	11	,	,	,
cord-017527-ylng1us2	330	12	these	these	DT
cord-017527-ylng1us2	330	13	cultures	culture	NNS
cord-017527-ylng1us2	330	14	must	must	MD
cord-017527-ylng1us2	330	15	be	be	VB
cord-017527-ylng1us2	330	16	obtained	obtain	VBN
cord-017527-ylng1us2	330	17	from	from	IN
cord-017527-ylng1us2	330	18	fresh	fresh	JJ
cord-017527-ylng1us2	330	19	tissue	tissue	NN
cord-017527-ylng1us2	330	20	that	that	WDT
cord-017527-ylng1us2	330	21	may	may	MD
cord-017527-ylng1us2	330	22	contain	contain	VB
cord-017527-ylng1us2	330	23	or	or	CC
cord-017527-ylng1us2	330	24	may	may	MD
cord-017527-ylng1us2	330	25	become	become	VB
cord-017527-ylng1us2	330	26	inadvertently	inadvertently	RB
cord-017527-ylng1us2	330	27	contaminated	contaminate	VBN
cord-017527-ylng1us2	330	28	with	with	IN
cord-017527-ylng1us2	330	29	pathogens	pathogen	NNS
cord-017527-ylng1us2	330	30	.	.	.
cord-017527-ylng1us2	331	1	Consequently	consequently	RB
cord-017527-ylng1us2	331	2	,	,	,
cord-017527-ylng1us2	331	3	primary	primary	JJ
cord-017527-ylng1us2	331	4	cell	cell	NN
cord-017527-ylng1us2	331	5	cultures	culture	NNS
cord-017527-ylng1us2	331	6	may	may	MD
cord-017527-ylng1us2	331	7	potentially	potentially	RB
cord-017527-ylng1us2	331	8	present	present	VB
cord-017527-ylng1us2	331	9	increased	increase	VBN
cord-017527-ylng1us2	331	10	risks	risk	NNS
cord-017527-ylng1us2	331	11	compared	compare	VBN
cord-017527-ylng1us2	331	12	to	to	IN
cord-017527-ylng1us2	331	13	continuous	continuous	JJ
cord-017527-ylng1us2	331	14	,	,	,
cord-017527-ylng1us2	331	15	established	established	JJ
cord-017527-ylng1us2	331	16	cell	cell	NN
cord-017527-ylng1us2	331	17	lines	line	NNS
cord-017527-ylng1us2	331	18	.	.	.
cord-017527-ylng1us2	332	1	Diploid	diploid	JJ
cord-017527-ylng1us2	332	2	cell	cell	NN
cord-017527-ylng1us2	332	3	lines	line	NNS
cord-017527-ylng1us2	332	4	Are	be	VBP
cord-017527-ylng1us2	332	5	similar	similar	JJ
cord-017527-ylng1us2	332	6	to	to	IN
cord-017527-ylng1us2	332	7	primary	primary	JJ
cord-017527-ylng1us2	332	8	cells	cell	NNS
cord-017527-ylng1us2	332	9	,	,	,
cord-017527-ylng1us2	332	10	are	be	VBP
cord-017527-ylng1us2	332	11	considered	consider	VBN
cord-017527-ylng1us2	332	12	non	non	JJ
cord-017527-ylng1us2	332	13	-	-	JJ
cord-017527-ylng1us2	332	14	tumourogenic	tumourogenic	JJ
cord-017527-ylng1us2	332	15	and	and	CC
cord-017527-ylng1us2	332	16	have	have	VB
cord-017527-ylng1us2	332	17	a	a	DT
cord-017527-ylng1us2	332	18	finite	finite	JJ
cord-017527-ylng1us2	332	19	capacity	capacity	NN
cord-017527-ylng1us2	332	20	for	for	IN
cord-017527-ylng1us2	332	21	serial	serial	JJ
cord-017527-ylng1us2	332	22	propagation	propagation	NN
cord-017527-ylng1us2	332	23	.	.	.
cord-017527-ylng1us2	333	1	They	-PRON-	PRP
cord-017527-ylng1us2	333	2	are	be	VBP
cord-017527-ylng1us2	333	3	used	use	VBN
cord-017527-ylng1us2	333	4	for	for	IN
cord-017527-ylng1us2	333	5	the	the	DT
cord-017527-ylng1us2	333	6	preparation	preparation	NN
cord-017527-ylng1us2	333	7	of	of	IN
cord-017527-ylng1us2	333	8	viral	viral	JJ
cord-017527-ylng1us2	333	9	vaccines	vaccine	NNS
cord-017527-ylng1us2	333	10	and	and	CC
cord-017527-ylng1us2	333	11	are	be	VBP
cord-017527-ylng1us2	333	12	from	from	IN
cord-017527-ylng1us2	333	13	human	human	JJ
cord-017527-ylng1us2	333	14	or	or	CC
cord-017527-ylng1us2	333	15	monkey	monkey	NN
cord-017527-ylng1us2	333	16	origin	origin	NN
cord-017527-ylng1us2	333	17	.	.	.
cord-017527-ylng1us2	334	1	Continuous	continuous	JJ
cord-017527-ylng1us2	334	2	cell	cell	NN
cord-017527-ylng1us2	334	3	lines	line	NNS
cord-017527-ylng1us2	334	4	Are	be	VBP
cord-017527-ylng1us2	334	5	immortalized	immortalize	VBN
cord-017527-ylng1us2	334	6	cells	cell	NNS
cord-017527-ylng1us2	334	7	that	that	WDT
cord-017527-ylng1us2	334	8	may	may	MD
cord-017527-ylng1us2	334	9	survive	survive	VB
cord-017527-ylng1us2	334	10	almost	almost	RB
cord-017527-ylng1us2	334	11	infinite	infinite	JJ
cord-017527-ylng1us2	334	12	serial	serial	JJ
cord-017527-ylng1us2	334	13	passages	passage	NNS
cord-017527-ylng1us2	334	14	.	.	.
cord-017527-ylng1us2	335	1	These	these	DT
cord-017527-ylng1us2	335	2	cells	cell	NNS
cord-017527-ylng1us2	335	3	are	be	VBP
cord-017527-ylng1us2	335	4	obtained	obtain	VBN
cord-017527-ylng1us2	335	5	by	by	IN
cord-017527-ylng1us2	335	6	either	either	DT
cord-017527-ylng1us2	335	7	isolating	isolate	VBG
cord-017527-ylng1us2	335	8	cells	cell	NNS
cord-017527-ylng1us2	335	9	from	from	IN
cord-017527-ylng1us2	335	10	tumours	tumour	NNS
cord-017527-ylng1us2	335	11	(	(	-LRB-
cord-017527-ylng1us2	335	12	neoplastic	neoplastic	JJ
cord-017527-ylng1us2	335	13	origin	origin	NN
cord-017527-ylng1us2	335	14	)	)	-RRB-
cord-017527-ylng1us2	335	15	,	,	,
cord-017527-ylng1us2	335	16	primary	primary	JJ
cord-017527-ylng1us2	335	17	cells	cell	NNS
cord-017527-ylng1us2	335	18	treated	treat	VBN
cord-017527-ylng1us2	335	19	with	with	IN
cord-017527-ylng1us2	335	20	mutagens	mutagen	NNS
cord-017527-ylng1us2	335	21	,	,	,
cord-017527-ylng1us2	335	22	oncogenic	oncogenic	JJ
cord-017527-ylng1us2	335	23	viruses	virus	NNS
cord-017527-ylng1us2	335	24	or	or	CC
cord-017527-ylng1us2	335	25	recombinant	recombinant	JJ
cord-017527-ylng1us2	335	26	DNA	dna	NN
cord-017527-ylng1us2	335	27	(	(	-LRB-
cord-017527-ylng1us2	335	28	oncogenes	oncogene	NNS
cord-017527-ylng1us2	335	29	)	)	-RRB-
cord-017527-ylng1us2	335	30	or	or	CC
cord-017527-ylng1us2	335	31	by	by	IN
cord-017527-ylng1us2	335	32	cell	cell	NN
cord-017527-ylng1us2	335	33	fusioning	fusioning	NN
cord-017527-ylng1us2	335	34	of	of	IN
cord-017527-ylng1us2	335	35	primary	primary	JJ
cord-017527-ylng1us2	335	36	cells	cell	NNS
cord-017527-ylng1us2	335	37	with	with	IN
cord-017527-ylng1us2	335	38	a	a	DT
cord-017527-ylng1us2	335	39	continuous	continuous	JJ
cord-017527-ylng1us2	335	40	cell	cell	NN
cord-017527-ylng1us2	335	41	line	line	NN
cord-017527-ylng1us2	335	42	.	.	.
cord-017527-ylng1us2	336	1	As	as	IN
cord-017527-ylng1us2	336	2	a	a	DT
cord-017527-ylng1us2	336	3	consequence	consequence	NN
cord-017527-ylng1us2	336	4	,	,	,
cord-017527-ylng1us2	336	5	the	the	DT
cord-017527-ylng1us2	336	6	class	class	NN
cord-017527-ylng1us2	336	7	of	of	IN
cord-017527-ylng1us2	336	8	risk	risk	NN
cord-017527-ylng1us2	336	9	of	of	IN
cord-017527-ylng1us2	336	10	these	these	DT
cord-017527-ylng1us2	336	11	cell	cell	NN
cord-017527-ylng1us2	336	12	lines	line	NNS
cord-017527-ylng1us2	336	13	is	be	VBZ
cord-017527-ylng1us2	336	14	often	often	RB
cord-017527-ylng1us2	336	15	correlated	correlate	VBN
cord-017527-ylng1us2	336	16	to	to	IN
cord-017527-ylng1us2	336	17	the	the	DT
cord-017527-ylng1us2	336	18	class	class	NN
cord-017527-ylng1us2	336	19	of	of	IN
cord-017527-ylng1us2	336	20	risk	risk	NN
cord-017527-ylng1us2	336	21	of	of	IN
cord-017527-ylng1us2	336	22	primary	primary	JJ
cord-017527-ylng1us2	336	23	cells	cell	NNS
cord-017527-ylng1us2	336	24	of	of	IN
cord-017527-ylng1us2	336	25	whom	whom	WP
cord-017527-ylng1us2	336	26	they	-PRON-	PRP
cord-017527-ylng1us2	336	27	are	be	VBP
cord-017527-ylng1us2	336	28	derived	derive	VBN
cord-017527-ylng1us2	336	29	.	.	.
cord-017527-ylng1us2	337	1	Due	due	IN
cord-017527-ylng1us2	337	2	to	to	IN
cord-017527-ylng1us2	337	3	the	the	DT
cord-017527-ylng1us2	337	4	"	"	``
cord-017527-ylng1us2	337	5	immortality	immortality	NN
cord-017527-ylng1us2	337	6	"	"	''
cord-017527-ylng1us2	337	7	of	of	IN
cord-017527-ylng1us2	337	8	the	the	DT
cord-017527-ylng1us2	337	9	continuous	continuous	JJ
cord-017527-ylng1us2	337	10	cell	cell	NN
cord-017527-ylng1us2	337	11	lines	line	NNS
cord-017527-ylng1us2	337	12	,	,	,
cord-017527-ylng1us2	337	13	their	-PRON-	PRP$
cord-017527-ylng1us2	337	14	ability	ability	NN
cord-017527-ylng1us2	337	15	to	to	TO
cord-017527-ylng1us2	337	16	induce	induce	VB
cord-017527-ylng1us2	337	17	tumours	tumour	NNS
cord-017527-ylng1us2	337	18	has	have	VBZ
cord-017527-ylng1us2	337	19	also	also	RB
cord-017527-ylng1us2	337	20	to	to	TO
cord-017527-ylng1us2	337	21	be	be	VB
cord-017527-ylng1us2	337	22	considered	consider	VBN
cord-017527-ylng1us2	337	23	.	.	.
cord-017527-ylng1us2	338	1	Transfection	Transfection	NNP
cord-017527-ylng1us2	338	2	Gene	Gene	NNP
cord-017527-ylng1us2	338	3	transfer	transfer	NN
cord-017527-ylng1us2	338	4	of	of	IN
cord-017527-ylng1us2	338	5	DNA	dna	NN
cord-017527-ylng1us2	338	6	in	in	IN
cord-017527-ylng1us2	338	7	eukaryotic	eukaryotic	JJ
cord-017527-ylng1us2	338	8	cells	cell	NNS
cord-017527-ylng1us2	338	9	using	use	VBG
cord-017527-ylng1us2	338	10	non	non	JJ
cord-017527-ylng1us2	338	11	-	-	JJ
cord-017527-ylng1us2	338	12	viral	viral	JJ
cord-017527-ylng1us2	338	13	delivery	delivery	NN
cord-017527-ylng1us2	338	14	methods	method	NNS
cord-017527-ylng1us2	338	15	.	.	.
cord-017527-ylng1us2	339	1	Transduction	transduction	NN
cord-017527-ylng1us2	339	2	Gene	Gene	NNP
cord-017527-ylng1us2	339	3	transfer	transfer	NN
cord-017527-ylng1us2	339	4	of	of	IN
cord-017527-ylng1us2	339	5	DNA	dna	NN
cord-017527-ylng1us2	339	6	in	in	IN
cord-017527-ylng1us2	339	7	eukaryotic	eukaryotic	JJ
cord-017527-ylng1us2	339	8	cells	cell	NNS
cord-017527-ylng1us2	339	9	using	use	VBG
cord-017527-ylng1us2	339	10	viral	viral	JJ
cord-017527-ylng1us2	339	11	vectors	vector	NNS
cord-017527-ylng1us2	339	12	.	.	.
cord-017527-ylng1us2	340	1	Infection	infection	NN
cord-017527-ylng1us2	340	2	Process	process	NN
cord-017527-ylng1us2	340	3	occurring	occur	VBG
cord-017527-ylng1us2	340	4	when	when	WRB
cord-017527-ylng1us2	340	5	a	a	DT
cord-017527-ylng1us2	340	6	virus	virus	NN
cord-017527-ylng1us2	340	7	(	(	-LRB-
cord-017527-ylng1us2	340	8	wild	wild	JJ
cord-017527-ylng1us2	340	9	type	type	NN
cord-017527-ylng1us2	340	10	)	)	-RRB-
cord-017527-ylng1us2	340	11	that	that	WDT
cord-017527-ylng1us2	340	12	typically	typically	RB
cord-017527-ylng1us2	340	13	replicates	replicate	VBZ
cord-017527-ylng1us2	340	14	and	and	CC
cord-017527-ylng1us2	340	15	spreads	spread	VBZ
cord-017527-ylng1us2	340	16	into	into	IN
cord-017527-ylng1us2	340	17	neighbouring	neighbouring	JJ
cord-017527-ylng1us2	340	18	cells	cell	NNS
cord-017527-ylng1us2	340	19	mediates	mediate	VBZ
cord-017527-ylng1us2	340	20	a	a	DT
cord-017527-ylng1us2	340	21	gene	gene	NN
cord-017527-ylng1us2	340	22	transfer	transfer	NN
cord-017527-ylng1us2	340	23	belonging	belong	VBG
cord-017527-ylng1us2	340	24	to	to	IN
cord-017527-ylng1us2	340	25	its	-PRON-	PRP$
cord-017527-ylng1us2	340	26	own	own	JJ
cord-017527-ylng1us2	340	27	genome	genome	NN
cord-017527-ylng1us2	340	28	or	or	CC
cord-017527-ylng1us2	340	29	extra	extra	JJ
cord-017527-ylng1us2	340	30	genes	gene	NNS
cord-017527-ylng1us2	340	31	it	-PRON-	PRP
cord-017527-ylng1us2	340	32	may	may	MD
cord-017527-ylng1us2	340	33	carry	carry	VB
cord-017527-ylng1us2	340	34	.	.	.
cord-017527-ylng1us2	341	1	Viral	viral	JJ
cord-017527-ylng1us2	341	2	vector	vector	NN
cord-017527-ylng1us2	341	3	Is	be	VBZ
cord-017527-ylng1us2	341	4	a	a	DT
cord-017527-ylng1us2	341	5	protein	protein	NN
cord-017527-ylng1us2	341	6	particle	particle	NN
cord-017527-ylng1us2	341	7	derived	derive	VBN
cord-017527-ylng1us2	341	8	from	from	IN
cord-017527-ylng1us2	341	9	a	a	DT
cord-017527-ylng1us2	341	10	replicative	replicative	JJ
cord-017527-ylng1us2	341	11	virus	virus	NN
cord-017527-ylng1us2	341	12	that	that	WDT
cord-017527-ylng1us2	341	13	contains	contain	VBZ
cord-017527-ylng1us2	341	14	genetic	genetic	JJ
cord-017527-ylng1us2	341	15	information	information	NN
cord-017527-ylng1us2	341	16	in	in	IN
cord-017527-ylng1us2	341	17	the	the	DT
cord-017527-ylng1us2	341	18	form	form	NN
cord-017527-ylng1us2	341	19	of	of	IN
cord-017527-ylng1us2	341	20	RNA	RNA	NNP
cord-017527-ylng1us2	341	21	or	or	CC
cord-017527-ylng1us2	341	22	DNA	DNA	NNP
cord-017527-ylng1us2	341	23	.	.	.
cord-017527-ylng1us2	342	1	A	a	DT
cord-017527-ylng1us2	342	2	viral	viral	JJ
cord-017527-ylng1us2	342	3	envelope	envelope	NN
cord-017527-ylng1us2	342	4	may	may	MD
cord-017527-ylng1us2	342	5	be	be	VB
cord-017527-ylng1us2	342	6	present	present	JJ
cord-017527-ylng1us2	342	7	as	as	RB
cord-017527-ylng1us2	342	8	well	well	RB
cord-017527-ylng1us2	342	9	.	.	.
cord-017527-ylng1us2	343	1	The	the	DT
cord-017527-ylng1us2	343	2	approved	approved	JJ
cord-017527-ylng1us2	343	3	list	list	NN
cord-017527-ylng1us2	343	4	of	of	IN
cord-017527-ylng1us2	343	5	biological	biological	JJ
cord-017527-ylng1us2	343	6	Agents	Agents	NNPS
cord-017527-ylng1us2	343	7	,	,	,
cord-017527-ylng1us2	343	8	3rd	3rd	JJ
cord-017527-ylng1us2	343	9	edn	edn	NN
cord-017527-ylng1us2	343	10	.	.	.
cord-017527-ylng1us2	344	1	Health	Health	NNP
cord-017527-ylng1us2	344	2	and	and	CC
cord-017527-ylng1us2	344	3	Safety	Safety	NNP
cord-017527-ylng1us2	344	4	Executive	Executive	NNP
cord-017527-ylng1us2	344	5	Disruption	Disruption	NNP
cord-017527-ylng1us2	344	6	of	of	IN
cord-017527-ylng1us2	344	7	3D	3d	JJ
cord-017527-ylng1us2	344	8	tissue	tissue	NN
cord-017527-ylng1us2	344	9	integrity	integrity	NN
cord-017527-ylng1us2	344	10	facilitates	facilitate	VBZ
cord-017527-ylng1us2	344	11	adenovirus	adenovirus	NN
cord-017527-ylng1us2	344	12	infection	infection	NN
cord-017527-ylng1us2	344	13	by	by	IN
cord-017527-ylng1us2	344	14	deregulating	deregulate	VBG
cord-017527-ylng1us2	344	15	the	the	DT
cord-017527-ylng1us2	344	16	coxsackievirus	coxsackievirus	NNP
cord-017527-ylng1us2	344	17	and	and	CC
cord-017527-ylng1us2	344	18	adenovirus	adenovirus	NN
cord-017527-ylng1us2	344	19	receptor	receptor	NN
cord-017527-ylng1us2	344	20	Washout	washout	NN
cord-017527-ylng1us2	344	21	kinetics	kinetic	NNS
cord-017527-ylng1us2	344	22	of	of	IN
cord-017527-ylng1us2	344	23	viral	viral	JJ
cord-017527-ylng1us2	344	24	vectors	vector	NNS
cord-017527-ylng1us2	344	25	from	from	IN
cord-017527-ylng1us2	344	26	culture	culture	NN
cord-017527-ylng1us2	344	27	mammalian	mammalian	JJ
cord-017527-ylng1us2	344	28	cells	cell	NNS
cord-017527-ylng1us2	345	1	General	general	JJ
cord-017527-ylng1us2	345	2	considerations	consideration	NNS
cord-017527-ylng1us2	345	3	on	on	IN
cord-017527-ylng1us2	345	4	the	the	DT
cord-017527-ylng1us2	345	5	biosafety	biosafety	NN
cord-017527-ylng1us2	345	6	of	of	IN
cord-017527-ylng1us2	345	7	virus	virus	NN
cord-017527-ylng1us2	345	8	-	-	HYPH
cord-017527-ylng1us2	345	9	derived	derive	VBN
cord-017527-ylng1us2	345	10	vectors	vector	NNS
cord-017527-ylng1us2	345	11	used	use	VBN
cord-017527-ylng1us2	345	12	in	in	IN
cord-017527-ylng1us2	345	13	gene	gene	NN
cord-017527-ylng1us2	345	14	therapy	therapy	NN
cord-017527-ylng1us2	345	15	and	and	CC
cord-017527-ylng1us2	345	16	vaccination	vaccination	NN
cord-017527-ylng1us2	345	17	Survival	survival	NN
cord-017527-ylng1us2	345	18	of	of	IN
cord-017527-ylng1us2	345	19	influenza	influenza	NN
cord-017527-ylng1us2	345	20	viruses	virus	NNS
cord-017527-ylng1us2	345	21	on	on	IN
cord-017527-ylng1us2	345	22	environmental	environmental	JJ
cord-017527-ylng1us2	345	23	surfaces	surface	NNS
cord-017527-ylng1us2	345	24	Belgian	belgian	JJ
cord-017527-ylng1us2	345	25	classifications	classification	NNS
cord-017527-ylng1us2	345	26	for	for	IN
cord-017527-ylng1us2	345	27	micro	micro	NNS
cord-017527-ylng1us2	345	28	-	-	NNS
cord-017527-ylng1us2	345	29	organisms	organism	NNS
cord-017527-ylng1us2	345	30	based	base	VBN
cord-017527-ylng1us2	345	31	on	on	IN
cord-017527-ylng1us2	345	32	their	-PRON-	PRP$
cord-017527-ylng1us2	345	33	biological	biological	JJ
cord-017527-ylng1us2	345	34	risks	risk	NNS
cord-017527-ylng1us2	345	35	Identification	identification	NN
cord-017527-ylng1us2	345	36	of	of	IN
cord-017527-ylng1us2	345	37	potentially	potentially	RB
cord-017527-ylng1us2	345	38	hazardous	hazardous	JJ
cord-017527-ylng1us2	345	39	human	human	JJ
cord-017527-ylng1us2	345	40	gene	gene	NN
cord-017527-ylng1us2	345	41	products	product	NNS
cord-017527-ylng1us2	345	42	in	in	IN
cord-017527-ylng1us2	345	43	GMO	GMO	NNP
cord-017527-ylng1us2	345	44	risk	risk	NN
cord-017527-ylng1us2	345	45	assessment	assessment	NN
cord-017527-ylng1us2	345	46	Detection	detection	NN
cord-017527-ylng1us2	345	47	of	of	IN
cord-017527-ylng1us2	345	48	human	human	JJ
cord-017527-ylng1us2	345	49	T	t	NN
cord-017527-ylng1us2	345	50	-	-	HYPH
cord-017527-ylng1us2	345	51	cell	cell	NN
cord-017527-ylng1us2	345	52	lymphoma	lymphoma	NN
cord-017527-ylng1us2	345	53	/	/	SYM
cord-017527-ylng1us2	345	54	leukemia	leukemia	NN
cord-017527-ylng1us2	345	55	virus	virus	NN
cord-017527-ylng1us2	345	56	type	type	NN
cord-017527-ylng1us2	345	57	I	-PRON-	PRP
cord-017527-ylng1us2	345	58	DNA	dna	VBP
cord-017527-ylng1us2	345	59	and	and	CC
cord-017527-ylng1us2	345	60	antigen	antigen	NN
cord-017527-ylng1us2	345	61	in	in	IN
cord-017527-ylng1us2	345	62	spinal	spinal	JJ
cord-017527-ylng1us2	345	63	fluid	fluid	NN
cord-017527-ylng1us2	345	64	and	and	CC
cord-017527-ylng1us2	345	65	blood	blood	NN
cord-017527-ylng1us2	345	66	of	of	IN
cord-017527-ylng1us2	345	67	patients	patient	NNS
cord-017527-ylng1us2	345	68	with	with	IN
cord-017527-ylng1us2	345	69	chronic	chronic	JJ
cord-017527-ylng1us2	345	70	progressive	progressive	JJ
cord-017527-ylng1us2	345	71	myelopathy	myelopathy	NN
cord-017527-ylng1us2	345	72	Threat	threat	NN
cord-017527-ylng1us2	345	73	to	to	IN
cord-017527-ylng1us2	345	74	humans	human	NNS
cord-017527-ylng1us2	345	75	from	from	IN
cord-017527-ylng1us2	345	76	virus	virus	NN
cord-017527-ylng1us2	345	77	infections	infection	NNS
cord-017527-ylng1us2	345	78	of	of	IN
cord-017527-ylng1us2	345	79	non	non	JJ
cord-017527-ylng1us2	345	80	-	-	JJ
cord-017527-ylng1us2	345	81	human	human	JJ
cord-017527-ylng1us2	345	82	primates	primate	NNS
cord-017527-ylng1us2	345	83	Cell	Cell	NNP
cord-017527-ylng1us2	345	84	line	line	NN
cord-017527-ylng1us2	345	85	cross	cross	NN
cord-017527-ylng1us2	345	86	-	-	NN
cord-017527-ylng1us2	345	87	contamination	contamination	NN
cord-017527-ylng1us2	346	1	:	:	:
cord-017527-ylng1us2	346	2	how	how	WRB
cord-017527-ylng1us2	346	3	aware	aware	JJ
cord-017527-ylng1us2	346	4	are	be	VBP
cord-017527-ylng1us2	346	5	Mammalian	mammalian	JJ
cord-017527-ylng1us2	346	6	cell	cell	NN
cord-017527-ylng1us2	346	7	culturists	culturist	NNS
cord-017527-ylng1us2	346	8	of	of	IN
cord-017527-ylng1us2	346	9	the	the	DT
cord-017527-ylng1us2	346	10	problem	problem	NN
cord-017527-ylng1us2	346	11	and	and	CC
cord-017527-ylng1us2	346	12	how	how	WRB
cord-017527-ylng1us2	346	13	to	to	TO
cord-017527-ylng1us2	346	14	monitor	monitor	VB
cord-017527-ylng1us2	346	15	it	-PRON-	PRP
cord-017527-ylng1us2	346	16	?	?	.
cord-017527-ylng1us2	347	1	In	in	IN
cord-017527-ylng1us2	347	2	vitro	vitro	FW
cord-017527-ylng1us2	347	3	cellular	cellular	JJ
cord-017527-ylng1us2	347	4	and	and	CC
cord-017527-ylng1us2	347	5	developmental	developmental	JJ
cord-017527-ylng1us2	347	6	biology	biology	NN
cord-017527-ylng1us2	348	1	Scrapie	Scrapie	NNP
cord-017527-ylng1us2	348	2	-	-	HYPH
cord-017527-ylng1us2	348	3	infected	infect	VBN
cord-017527-ylng1us2	348	4	murine	murine	JJ
cord-017527-ylng1us2	348	5	neuroblastoma	neuroblastoma	NN
cord-017527-ylng1us2	348	6	cells	cell	NNS
cord-017527-ylng1us2	348	7	produce	produce	VBP
cord-017527-ylng1us2	348	8	protease	protease	NN
cord-017527-ylng1us2	348	9	-	-	HYPH
cord-017527-ylng1us2	348	10	resistant	resistant	JJ
cord-017527-ylng1us2	348	11	prion	prion	NN
cord-017527-ylng1us2	348	12	proteins	protein	NNS
cord-017527-ylng1us2	349	1	A	a	DT
cord-017527-ylng1us2	349	2	non	non	JJ
cord-017527-ylng1us2	349	3	-	-	JJ
cord-017527-ylng1us2	349	4	infectious	infectious	JJ
cord-017527-ylng1us2	349	5	cell	cell	NN
cord-017527-ylng1us2	349	6	-	-	HYPH
cord-017527-ylng1us2	349	7	based	base	VBN
cord-017527-ylng1us2	349	8	phenotypic	phenotypic	JJ
cord-017527-ylng1us2	349	9	assay	assay	NN
cord-017527-ylng1us2	349	10	for	for	IN
cord-017527-ylng1us2	349	11	the	the	DT
cord-017527-ylng1us2	349	12	assessment	assessment	NN
cord-017527-ylng1us2	349	13	of	of	IN
cord-017527-ylng1us2	349	14	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	349	15	susceptibility	susceptibility	NN
cord-017527-ylng1us2	349	16	to	to	IN
cord-017527-ylng1us2	349	17	protease	protease	NN
cord-017527-ylng1us2	349	18	inhibitors	inhibitor	NNS
cord-017527-ylng1us2	349	19	Identity	identity	NN
cord-017527-ylng1us2	349	20	tests	test	NNS
cord-017527-ylng1us2	349	21	:	:	:
cord-017527-ylng1us2	350	1	determination	determination	NN
cord-017527-ylng1us2	350	2	of	of	IN
cord-017527-ylng1us2	350	3	ell	ell	NNP
cord-017527-ylng1us2	350	4	line	line	NNP
cord-017527-ylng1us2	350	5	cross	cross	NN
cord-017527-ylng1us2	350	6	-	-	NN
cord-017527-ylng1us2	350	7	contamination	contamination	NN
cord-017527-ylng1us2	350	8	Check	check	VB
cord-017527-ylng1us2	350	9	your	-PRON-	PRP$
cord-017527-ylng1us2	350	10	cultures	culture	NNS
cord-017527-ylng1us2	350	11	!	!	.
cord-017527-ylng1us2	351	1	A	a	DT
cord-017527-ylng1us2	351	2	list	list	NN
cord-017527-ylng1us2	351	3	of	of	IN
cord-017527-ylng1us2	351	4	cross	cross	JJ
cord-017527-ylng1us2	351	5	-	-	JJ
cord-017527-ylng1us2	351	6	contaminated	contaminated	JJ
cord-017527-ylng1us2	351	7	or	or	CC
cord-017527-ylng1us2	351	8	misidentified	misidentifie	VBN
cord-017527-ylng1us2	351	9	cell	cell	NN
cord-017527-ylng1us2	351	10	lines	line	NNS
cord-017527-ylng1us2	351	11	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	351	12	in	in	IN
cord-017527-ylng1us2	351	13	Microbiological	Microbiological	NNP
cord-017527-ylng1us2	351	14	and	and	CC
cord-017527-ylng1us2	351	15	Biomedical	Biomedical	NNP
cord-017527-ylng1us2	351	16	Laboratories	Laboratories	NNP
cord-017527-ylng1us2	351	17	(	(	-LRB-
cord-017527-ylng1us2	351	18	BMBL	BMBL	NNP
cord-017527-ylng1us2	351	19	)	)	-RRB-
cord-017527-ylng1us2	351	20	5th	5th	JJ
cord-017527-ylng1us2	351	21	edn	edn	NNP
cord-017527-ylng1us2	351	22	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	351	23	-	-	HYPH
cord-017527-ylng1us2	351	24	acquired	acquire	VBN
cord-017527-ylng1us2	351	25	vaccinia	vaccinia	NN
cord-017527-ylng1us2	351	26	virus	virus	NN
cord-017527-ylng1us2	351	27	infection	infection	NN
cord-017527-ylng1us2	351	28	,	,	,
cord-017527-ylng1us2	351	29	United	United	NNP
cord-017527-ylng1us2	351	30	States	States	NNP
cord-017527-ylng1us2	351	31	(	(	-LRB-
cord-017527-ylng1us2	351	32	Virginia	Virginia	NNP
cord-017527-ylng1us2	351	33	)	)	-RRB-
cord-017527-ylng1us2	351	34	2008	2008	CD
cord-017527-ylng1us2	351	35	.	.	.
cord-017527-ylng1us2	352	1	Morbidity	morbidity	NN
cord-017527-ylng1us2	352	2	and	and	CC
cord-017527-ylng1us2	352	3	mortality	mortality	NN
cord-017527-ylng1us2	352	4	weekly	weekly	JJ
cord-017527-ylng1us2	352	5	report	report	NN
cord-017527-ylng1us2	352	6	Wildlife	Wildlife	NNP
cord-017527-ylng1us2	352	7	,	,	,
cord-017527-ylng1us2	352	8	exotic	exotic	JJ
cord-017527-ylng1us2	352	9	pets	pet	NNS
cord-017527-ylng1us2	352	10	,	,	,
cord-017527-ylng1us2	352	11	and	and	CC
cord-017527-ylng1us2	352	12	emerging	emerge	VBG
cord-017527-ylng1us2	352	13	zoonoses	zoonosis	NNS
cord-017527-ylng1us2	353	1	A	a	DT
cord-017527-ylng1us2	353	2	replication	replication	NN
cord-017527-ylng1us2	353	3	-	-	HYPH
cord-017527-ylng1us2	353	4	competent	competent	JJ
cord-017527-ylng1us2	353	5	retrovirus	retrovirus	NN
cord-017527-ylng1us2	353	6	arising	arise	VBG
cord-017527-ylng1us2	353	7	from	from	IN
cord-017527-ylng1us2	353	8	a	a	DT
cord-017527-ylng1us2	353	9	splitfunction	splitfunction	NN
cord-017527-ylng1us2	353	10	packaging	packaging	NN
cord-017527-ylng1us2	353	11	cell	cell	NN
cord-017527-ylng1us2	353	12	line	line	NN
cord-017527-ylng1us2	353	13	was	be	VBD
cord-017527-ylng1us2	353	14	generated	generate	VBN
cord-017527-ylng1us2	353	15	by	by	IN
cord-017527-ylng1us2	353	16	recombination	recombination	NN
cord-017527-ylng1us2	353	17	events	event	NNS
cord-017527-ylng1us2	353	18	between	between	IN
cord-017527-ylng1us2	353	19	the	the	DT
cord-017527-ylng1us2	353	20	vector	vector	NN
cord-017527-ylng1us2	353	21	,	,	,
cord-017527-ylng1us2	353	22	one	one	CD
cord-017527-ylng1us2	353	23	of	of	IN
cord-017527-ylng1us2	353	24	the	the	DT
cord-017527-ylng1us2	353	25	packaging	packaging	NN
cord-017527-ylng1us2	353	26	constructs	construct	NNS
cord-017527-ylng1us2	353	27	,	,	,
cord-017527-ylng1us2	353	28	and	and	CC
cord-017527-ylng1us2	353	29	endogenous	endogenous	JJ
cord-017527-ylng1us2	353	30	retroviral	retroviral	NN
cord-017527-ylng1us2	353	31	sequences	sequence	NNS
cord-017527-ylng1us2	353	32	Isolation	Isolation	NNP
cord-017527-ylng1us2	353	33	of	of	IN
cord-017527-ylng1us2	353	34	a	a	DT
cord-017527-ylng1us2	353	35	new	new	JJ
cord-017527-ylng1us2	353	36	human	human	JJ
cord-017527-ylng1us2	353	37	retrovirus	retrovirus	NN
cord-017527-ylng1us2	353	38	from	from	IN
cord-017527-ylng1us2	353	39	West	west	JJ
cord-017527-ylng1us2	353	40	African	african	JJ
cord-017527-ylng1us2	353	41	patients	patient	NNS
cord-017527-ylng1us2	353	42	with	with	IN
cord-017527-ylng1us2	353	43	AIDS	AIDS	NNP
cord-017527-ylng1us2	353	44	Microbiological	microbiological	JJ
cord-017527-ylng1us2	353	45	contamination	contamination	NN
cord-017527-ylng1us2	353	46	in	in	IN
cord-017527-ylng1us2	353	47	stem	stem	NN
cord-017527-ylng1us2	353	48	cell	cell	NN
cord-017527-ylng1us2	353	49	cultures	culture	NNS
cord-017527-ylng1us2	353	50	Prions	prion	NNS
cord-017527-ylng1us2	353	51	can	can	MD
cord-017527-ylng1us2	353	52	infect	infect	VB
cord-017527-ylng1us2	353	53	primary	primary	JJ
cord-017527-ylng1us2	353	54	cultured	cultured	JJ
cord-017527-ylng1us2	353	55	neurons	neuron	NNS
cord-017527-ylng1us2	353	56	and	and	CC
cord-017527-ylng1us2	353	57	astrocytes	astrocyte	NNS
cord-017527-ylng1us2	353	58	and	and	CC
cord-017527-ylng1us2	353	59	promote	promote	VB
cord-017527-ylng1us2	353	60	neuronal	neuronal	JJ
cord-017527-ylng1us2	353	61	cell	cell	NN
cord-017527-ylng1us2	353	62	death	death	NN
cord-017527-ylng1us2	353	63	Activation	activation	NN
cord-017527-ylng1us2	353	64	of	of	IN
cord-017527-ylng1us2	353	65	primary	primary	JJ
cord-017527-ylng1us2	353	66	porcine	porcine	JJ
cord-017527-ylng1us2	353	67	endothelial	endothelial	JJ
cord-017527-ylng1us2	353	68	cells	cell	NNS
cord-017527-ylng1us2	353	69	induces	induce	VBZ
cord-017527-ylng1us2	353	70	release	release	NN
cord-017527-ylng1us2	353	71	of	of	IN
cord-017527-ylng1us2	353	72	porcine	porcine	JJ
cord-017527-ylng1us2	353	73	endogenous	endogenous	JJ
cord-017527-ylng1us2	353	74	retroviruses	retrovirus	NNS
cord-017527-ylng1us2	353	75	Polio	Polio	NNP
cord-017527-ylng1us2	353	76	vaccines	vaccine	NNS
cord-017527-ylng1us2	353	77	,	,	,
cord-017527-ylng1us2	353	78	Simian	Simian	NNP
cord-017527-ylng1us2	353	79	Virus	Virus	NNP
cord-017527-ylng1us2	353	80	40	40	CD
cord-017527-ylng1us2	353	81	,	,	,
cord-017527-ylng1us2	353	82	and	and	CC
cord-017527-ylng1us2	353	83	human	human	JJ
cord-017527-ylng1us2	353	84	cancer	cancer	NN
cord-017527-ylng1us2	353	85	:	:	:
cord-017527-ylng1us2	354	1	the	the	DT
cord-017527-ylng1us2	354	2	epidemiologic	epidemiologic	JJ
cord-017527-ylng1us2	354	3	evidence	evidence	NN
cord-017527-ylng1us2	354	4	for	for	IN
cord-017527-ylng1us2	354	5	a	a	DT
cord-017527-ylng1us2	354	6	causal	causal	JJ
cord-017527-ylng1us2	354	7	association	association	NN
cord-017527-ylng1us2	354	8	B	B	NNP
cord-017527-ylng1us2	354	9	virus	virus	NN
cord-017527-ylng1us2	354	10	infection	infection	NN
cord-017527-ylng1us2	354	11	in	in	IN
cord-017527-ylng1us2	354	12	man	man	NN
cord-017527-ylng1us2	354	13	Foamy	foamy	JJ
cord-017527-ylng1us2	354	14	viruses	virus	NNS
cord-017527-ylng1us2	354	15	-a	-a	:
cord-017527-ylng1us2	354	16	world	world	NN
cord-017527-ylng1us2	354	17	apart	apart	RB
cord-017527-ylng1us2	354	18	Aerosol	Aerosol	NNP
cord-017527-ylng1us2	354	19	and	and	CC
cord-017527-ylng1us2	354	20	nasal	nasal	NN
cord-017527-ylng1us2	354	21	transmission	transmission	NN
cord-017527-ylng1us2	354	22	of	of	IN
cord-017527-ylng1us2	354	23	chronic	chronic	JJ
cord-017527-ylng1us2	354	24	wasting	waste	VBG
cord-017527-ylng1us2	354	25	disease	disease	NN
cord-017527-ylng1us2	354	26	in	in	IN
cord-017527-ylng1us2	354	27	cervidized	cervidize	VBN
cord-017527-ylng1us2	354	28	mice	mouse	NNS
cord-017527-ylng1us2	354	29	Nonhuman	Nonhuman	NNP
cord-017527-ylng1us2	354	30	primate	primate	JJ
cord-017527-ylng1us2	354	31	-	-	HYPH
cord-017527-ylng1us2	354	32	associated	associate	VBN
cord-017527-ylng1us2	354	33	viral	viral	JJ
cord-017527-ylng1us2	354	34	hepatitis	hepatitis	NN
cord-017527-ylng1us2	354	35	type	type	NN
cord-017527-ylng1us2	354	36	A.	A.	NNP
cord-017527-ylng1us2	354	37	Serologic	Serologic	NNP
cord-017527-ylng1us2	354	38	evidence	evidence	NN
cord-017527-ylng1us2	354	39	of	of	IN
cord-017527-ylng1us2	354	40	hepatitis	hepatitis	NN
cord-017527-ylng1us2	354	41	A	a	DT
cord-017527-ylng1us2	354	42	virus	virus	NN
cord-017527-ylng1us2	354	43	infection	infection	NN
cord-017527-ylng1us2	354	44	Use	use	NN
cord-017527-ylng1us2	354	45	of	of	IN
cord-017527-ylng1us2	354	46	bacteriophage	bacteriophage	NN
cord-017527-ylng1us2	354	47	particles	particle	NNS
cord-017527-ylng1us2	354	48	displaying	display	VBG
cord-017527-ylng1us2	354	49	influenza	influenza	NN
cord-017527-ylng1us2	354	50	virus	virus	NN
cord-017527-ylng1us2	354	51	hemagglutinin	hemagglutinin	NN
cord-017527-ylng1us2	354	52	for	for	IN
cord-017527-ylng1us2	354	53	the	the	DT
cord-017527-ylng1us2	354	54	detection	detection	NN
cord-017527-ylng1us2	354	55	of	of	IN
cord-017527-ylng1us2	354	56	hemagglutination	hemagglutination	NN
cord-017527-ylng1us2	354	57	-	-	HYPH
cord-017527-ylng1us2	354	58	inhibition	inhibition	NN
cord-017527-ylng1us2	354	59	antibodies	antibody	NNS
cord-017527-ylng1us2	354	60	Mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	354	61	contamination	contamination	NN
cord-017527-ylng1us2	354	62	of	of	IN
cord-017527-ylng1us2	354	63	cell	cell	NN
cord-017527-ylng1us2	354	64	cultures	culture	NNS
cord-017527-ylng1us2	355	1	A	a	DT
cord-017527-ylng1us2	355	2	third	third	JJ
cord-017527-ylng1us2	355	3	-	-	HYPH
cord-017527-ylng1us2	355	4	generation	generation	NN
cord-017527-ylng1us2	355	5	lentivirus	lentivirus	NN
cord-017527-ylng1us2	355	6	vector	vector	NN
cord-017527-ylng1us2	355	7	with	with	IN
cord-017527-ylng1us2	355	8	a	a	DT
cord-017527-ylng1us2	355	9	conditional	conditional	JJ
cord-017527-ylng1us2	355	10	packaging	packaging	NN
cord-017527-ylng1us2	355	11	system	system	NN
cord-017527-ylng1us2	355	12	Simian	simian	JJ
cord-017527-ylng1us2	355	13	herpesviruses	herpesviruse	NNS
cord-017527-ylng1us2	355	14	and	and	CC
cord-017527-ylng1us2	355	15	their	-PRON-	PRP$
cord-017527-ylng1us2	355	16	risk	risk	NN
cord-017527-ylng1us2	355	17	to	to	IN
cord-017527-ylng1us2	355	18	humans	human	NNS
cord-017527-ylng1us2	355	19	on	on	IN
cord-017527-ylng1us2	355	20	the	the	DT
cord-017527-ylng1us2	355	21	protection	protection	NN
cord-017527-ylng1us2	355	22	of	of	IN
cord-017527-ylng1us2	355	23	workers	worker	NNS
cord-017527-ylng1us2	355	24	from	from	IN
cord-017527-ylng1us2	355	25	risks	risk	NNS
cord-017527-ylng1us2	355	26	related	relate	VBN
cord-017527-ylng1us2	355	27	to	to	IN
cord-017527-ylng1us2	355	28	exposure	exposure	NN
cord-017527-ylng1us2	355	29	to	to	IN
cord-017527-ylng1us2	355	30	biological	biological	JJ
cord-017527-ylng1us2	355	31	agents	agent	NNS
cord-017527-ylng1us2	355	32	at	at	IN
cord-017527-ylng1us2	355	33	work	work	NN
cord-017527-ylng1us2	355	34	of	of	IN
cord-017527-ylng1us2	355	35	the	the	DT
cord-017527-ylng1us2	355	36	European	European	NNP
cord-017527-ylng1us2	355	37	Parliament	Parliament	NNP
cord-017527-ylng1us2	355	38	and	and	CC
cord-017527-ylng1us2	355	39	of	of	IN
cord-017527-ylng1us2	355	40	the	the	DT
cord-017527-ylng1us2	355	41	Council	Council	NNP
cord-017527-ylng1us2	355	42	of	of	IN
cord-017527-ylng1us2	355	43	31	31	CD
cord-017527-ylng1us2	355	44	March	March	NNP
cord-017527-ylng1us2	355	45	2004	2004	CD
cord-017527-ylng1us2	355	46	laying	lay	VBG
cord-017527-ylng1us2	355	47	down	down	RP
cord-017527-ylng1us2	355	48	Community	Community	NNP
cord-017527-ylng1us2	355	49	procedures	procedure	NNS
cord-017527-ylng1us2	355	50	for	for	IN
cord-017527-ylng1us2	355	51	the	the	DT
cord-017527-ylng1us2	355	52	authorization	authorization	NN
cord-017527-ylng1us2	355	53	and	and	CC
cord-017527-ylng1us2	355	54	supervision	supervision	NN
cord-017527-ylng1us2	355	55	of	of	IN
cord-017527-ylng1us2	355	56	medicinal	medicinal	JJ
cord-017527-ylng1us2	355	57	products	product	NNS
cord-017527-ylng1us2	355	58	for	for	IN
cord-017527-ylng1us2	355	59	human	human	JJ
cord-017527-ylng1us2	355	60	and	and	CC
cord-017527-ylng1us2	355	61	veterinary	veterinary	JJ
cord-017527-ylng1us2	355	62	use	use	NN
cord-017527-ylng1us2	355	63	and	and	CC
cord-017527-ylng1us2	355	64	establishing	establish	VBG
cord-017527-ylng1us2	355	65	a	a	DT
cord-017527-ylng1us2	355	66	European	European	NNP
cord-017527-ylng1us2	355	67	Medicines	Medicines	NNPS
cord-017527-ylng1us2	355	68	Agency	Agency	NNP
cord-017527-ylng1us2	355	69	.	.	.
cord-017527-ylng1us2	356	1	Off	off	IN
cord-017527-ylng1us2	356	2	J	J	NNP
cord-017527-ylng1us2	356	3	30.04	30.04	CD
cord-017527-ylng1us2	356	4	Directive	Directive	NNP
cord-017527-ylng1us2	356	5	2004/23	2004/23	CD
cord-017527-ylng1us2	356	6	/	/	SYM
cord-017527-ylng1us2	356	7	EC	EC	NNP
cord-017527-ylng1us2	356	8	of	of	IN
cord-017527-ylng1us2	356	9	the	the	DT
cord-017527-ylng1us2	356	10	European	European	NNP
cord-017527-ylng1us2	356	11	Parliament	Parliament	NNP
cord-017527-ylng1us2	356	12	and	and	CC
cord-017527-ylng1us2	356	13	of	of	IN
cord-017527-ylng1us2	356	14	the	the	DT
cord-017527-ylng1us2	356	15	Council	Council	NNP
cord-017527-ylng1us2	356	16	of	of	IN
cord-017527-ylng1us2	356	17	31	31	CD
cord-017527-ylng1us2	356	18	March	March	NNP
cord-017527-ylng1us2	356	19	2004	2004	CD
cord-017527-ylng1us2	356	20	on	on	IN
cord-017527-ylng1us2	356	21	setting	set	VBG
cord-017527-ylng1us2	356	22	standards	standard	NNS
cord-017527-ylng1us2	356	23	of	of	IN
cord-017527-ylng1us2	356	24	quality	quality	NN
cord-017527-ylng1us2	356	25	and	and	CC
cord-017527-ylng1us2	356	26	safety	safety	NN
cord-017527-ylng1us2	356	27	for	for	IN
cord-017527-ylng1us2	356	28	the	the	DT
cord-017527-ylng1us2	356	29	donation	donation	NN
cord-017527-ylng1us2	356	30	,	,	,
cord-017527-ylng1us2	356	31	procurement	procurement	NN
cord-017527-ylng1us2	356	32	,	,	,
cord-017527-ylng1us2	356	33	testing	testing	NN
cord-017527-ylng1us2	356	34	,	,	,
cord-017527-ylng1us2	356	35	processing	processing	NN
cord-017527-ylng1us2	356	36	,	,	,
cord-017527-ylng1us2	356	37	preservation	preservation	NN
cord-017527-ylng1us2	356	38	,	,	,
cord-017527-ylng1us2	356	39	storage	storage	NN
cord-017527-ylng1us2	356	40	and	and	CC
cord-017527-ylng1us2	356	41	distribution	distribution	NN
cord-017527-ylng1us2	356	42	of	of	IN
cord-017527-ylng1us2	356	43	human	human	JJ
cord-017527-ylng1us2	356	44	tissues	tissue	NNS
cord-017527-ylng1us2	356	45	and	and	CC
cord-017527-ylng1us2	356	46	cells	cell	NNS
cord-017527-ylng1us2	356	47	on	on	IN
cord-017527-ylng1us2	356	48	the	the	DT
cord-017527-ylng1us2	356	49	contained	contain	VBN
cord-017527-ylng1us2	356	50	use	use	NN
cord-017527-ylng1us2	356	51	of	of	IN
cord-017527-ylng1us2	356	52	genetically	genetically	RB
cord-017527-ylng1us2	356	53	modified	modify	VBN
cord-017527-ylng1us2	356	54	micro	micro	NNS
cord-017527-ylng1us2	356	55	-	-	HYPH
cord-017527-ylng1us2	356	56	organisms	organism	NNS
cord-017527-ylng1us2	356	57	Food	Food	NNP
cord-017527-ylng1us2	356	58	and	and	CC
cord-017527-ylng1us2	356	59	Drug	Drug	NNP
cord-017527-ylng1us2	356	60	Administration	Administration	NNP
cord-017527-ylng1us2	356	61	(	(	-LRB-
cord-017527-ylng1us2	356	62	FDA	FDA	NNP
cord-017527-ylng1us2	356	63	)	)	-RRB-
cord-017527-ylng1us2	356	64	.	.	.
cord-017527-ylng1us2	357	1	Centers	center	NNS
cord-017527-ylng1us2	357	2	for	for	IN
cord-017527-ylng1us2	357	3	biologics	biologic	NNS
cord-017527-ylng1us2	357	4	evaluation	evaluation	NN
cord-017527-ylng1us2	357	5	and	and	CC
cord-017527-ylng1us2	357	6	research	research	NN
cord-017527-ylng1us2	357	7	Cell	cell	NN
cord-017527-ylng1us2	357	8	culture	culture	NN
cord-017527-ylng1us2	357	9	and	and	CC
cord-017527-ylng1us2	357	10	electron	electron	NN
cord-017527-ylng1us2	357	11	microscopy	microscopy	NN
cord-017527-ylng1us2	357	12	for	for	IN
cord-017527-ylng1us2	357	13	identifying	identify	VBG
cord-017527-ylng1us2	357	14	viruses	virus	NNS
cord-017527-ylng1us2	357	15	in	in	IN
cord-017527-ylng1us2	357	16	diseases	disease	NNS
cord-017527-ylng1us2	357	17	of	of	IN
cord-017527-ylng1us2	357	18	unknown	unknown	JJ
cord-017527-ylng1us2	357	19	cause	cause	NN
cord-017527-ylng1us2	357	20	Correspondence	correspondence	NN
cord-017527-ylng1us2	357	21	.	.	.
cord-017527-ylng1us2	358	1	Needle	needle	NN
cord-017527-ylng1us2	358	2	-	-	HYPH
cord-017527-ylng1us2	358	3	stick	stick	NN
cord-017527-ylng1us2	358	4	transmission	transmission	NN
cord-017527-ylng1us2	358	5	of	of	IN
cord-017527-ylng1us2	358	6	human	human	JJ
cord-017527-ylng1us2	358	7	colonic	colonic	JJ
cord-017527-ylng1us2	358	8	adenocarcinoma	adenocarcinoma	NN
cord-017527-ylng1us2	358	9	AIDS	AIDS	NNP
cord-017527-ylng1us2	358	10	as	as	IN
cord-017527-ylng1us2	358	11	a	a	DT
cord-017527-ylng1us2	358	12	zoonosis	zoonosis	NN
cord-017527-ylng1us2	358	13	:	:	:
cord-017527-ylng1us2	358	14	scientific	scientific	JJ
cord-017527-ylng1us2	358	15	and	and	CC
cord-017527-ylng1us2	358	16	public	public	JJ
cord-017527-ylng1us2	358	17	health	health	NN
cord-017527-ylng1us2	358	18	implications	implication	NNS
cord-017527-ylng1us2	359	1	The	the	DT
cord-017527-ylng1us2	359	2	influence	influence	NN
cord-017527-ylng1us2	359	3	of	of	IN
cord-017527-ylng1us2	359	4	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	359	5	infection	infection	NN
cord-017527-ylng1us2	359	6	on	on	IN
cord-017527-ylng1us2	359	7	the	the	DT
cord-017527-ylng1us2	359	8	sensitivity	sensitivity	NN
cord-017527-ylng1us2	359	9	of	of	IN
cord-017527-ylng1us2	359	10	HeLa	HeLa	NNP
cord-017527-ylng1us2	359	11	cells	cell	NNS
cord-017527-ylng1us2	359	12	for	for	IN
cord-017527-ylng1us2	359	13	growth	growth	NN
cord-017527-ylng1us2	359	14	of	of	IN
cord-017527-ylng1us2	359	15	viruses	virus	NNS
cord-017527-ylng1us2	359	16	Operator	operator	NN
cord-017527-ylng1us2	359	17	-	-	HYPH
cord-017527-ylng1us2	359	18	induced	induce	VBN
cord-017527-ylng1us2	359	19	contamination	contamination	NN
cord-017527-ylng1us2	359	20	in	in	IN
cord-017527-ylng1us2	359	21	cell	cell	NN
cord-017527-ylng1us2	359	22	culture	culture	NN
cord-017527-ylng1us2	359	23	systems	system	NNS
cord-017527-ylng1us2	359	24	Aerosols	aerosol	NNS
cord-017527-ylng1us2	359	25	transmit	transmit	VBP
cord-017527-ylng1us2	359	26	prions	prion	NNS
cord-017527-ylng1us2	359	27	to	to	IN
cord-017527-ylng1us2	359	28	immunocompetent	immunocompetent	JJ
cord-017527-ylng1us2	359	29	and	and	CC
cord-017527-ylng1us2	359	30	immunodeficient	immunodeficient	JJ
cord-017527-ylng1us2	359	31	mice	mouse	NNS
cord-017527-ylng1us2	359	32	Biosafety	Biosafety	NNP
cord-017527-ylng1us2	359	33	risk	risk	NN
cord-017527-ylng1us2	359	34	assessment	assessment	NN
cord-017527-ylng1us2	359	35	of	of	IN
cord-017527-ylng1us2	359	36	the	the	DT
cord-017527-ylng1us2	359	37	severe	severe	JJ
cord-017527-ylng1us2	359	38	acute	acute	JJ
cord-017527-ylng1us2	359	39	respiratory	respiratory	JJ
cord-017527-ylng1us2	359	40	syndrome	syndrome	NN
cord-017527-ylng1us2	359	41	(	(	-LRB-
cord-017527-ylng1us2	359	42	SARS	SARS	NNP
cord-017527-ylng1us2	359	43	)	)	-RRB-
cord-017527-ylng1us2	359	44	Coronavirus	Coronavirus	NNP
cord-017527-ylng1us2	359	45	and	and	CC
cord-017527-ylng1us2	359	46	containment	containment	NN
cord-017527-ylng1us2	359	47	measures	measure	NNS
cord-017527-ylng1us2	359	48	for	for	IN
cord-017527-ylng1us2	359	49	the	the	DT
cord-017527-ylng1us2	359	50	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	359	51	and	and	CC
cord-017527-ylng1us2	359	52	research	research	NN
cord-017527-ylng1us2	359	53	laboratories	laboratory	NNS
cord-017527-ylng1us2	359	54	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	359	55	-	-	HYPH
cord-017527-ylng1us2	359	56	acquired	acquire	VBN
cord-017527-ylng1us2	359	57	parasitic	parasitic	JJ
cord-017527-ylng1us2	359	58	infections	infection	NNS
cord-017527-ylng1us2	359	59	from	from	IN
cord-017527-ylng1us2	359	60	accidental	accidental	JJ
cord-017527-ylng1us2	359	61	exposures	exposure	NNS
cord-017527-ylng1us2	359	62	Outbreak	outbreak	NN
cord-017527-ylng1us2	359	63	of	of	IN
cord-017527-ylng1us2	359	64	lymphocytic	lymphocytic	JJ
cord-017527-ylng1us2	359	65	choriomeningitis	choriomeningitis	NNP
cord-017527-ylng1us2	359	66	virus	virus	NN
cord-017527-ylng1us2	359	67	infections	infection	NNS
cord-017527-ylng1us2	359	68	in	in	IN
cord-017527-ylng1us2	359	69	medical	medical	JJ
cord-017527-ylng1us2	359	70	center	center	NN
cord-017527-ylng1us2	359	71	personnel	personnel	NNS
cord-017527-ylng1us2	359	72	Chronic	Chronic	NNP
cord-017527-ylng1us2	359	73	neurodegenerative	neurodegenerative	JJ
cord-017527-ylng1us2	359	74	disease	disease	NN
cord-017527-ylng1us2	359	75	associated	associate	VBN
cord-017527-ylng1us2	359	76	with	with	IN
cord-017527-ylng1us2	359	77	HTLV	HTLV	NNP
cord-017527-ylng1us2	359	78	-	-	HYPH
cord-017527-ylng1us2	359	79	II	ii	CD
cord-017527-ylng1us2	359	80	infection	infection	NN
cord-017527-ylng1us2	359	81	Encephalomyelitis	Encephalomyelitis	NNP
cord-017527-ylng1us2	359	82	due	due	JJ
cord-017527-ylng1us2	359	83	to	to	IN
cord-017527-ylng1us2	359	84	infection	infection	NN
cord-017527-ylng1us2	359	85	with	with	IN
cord-017527-ylng1us2	359	86	Herpesvirus	Herpesvirus	NNP
cord-017527-ylng1us2	359	87	simiae	simiae	NN
cord-017527-ylng1us2	359	88	Reproducible	reproducible	JJ
cord-017527-ylng1us2	359	89	culture	culture	NN
cord-017527-ylng1us2	359	90	and	and	CC
cord-017527-ylng1us2	359	91	differentiation	differentiation	NN
cord-017527-ylng1us2	359	92	of	of	IN
cord-017527-ylng1us2	359	93	mouse	mouse	NN
cord-017527-ylng1us2	359	94	embryonic	embryonic	JJ
cord-017527-ylng1us2	359	95	stem	stem	NN
cord-017527-ylng1us2	359	96	cells	cell	NNS
cord-017527-ylng1us2	359	97	using	use	VBG
cord-017527-ylng1us2	359	98	an	an	DT
cord-017527-ylng1us2	359	99	automated	automate	VBN
cord-017527-ylng1us2	359	100	microwell	microwell	JJ
cord-017527-ylng1us2	359	101	platform	platform	NN
cord-017527-ylng1us2	359	102	Step	Step	NNP
cord-017527-ylng1us2	359	103	4	4	CD
cord-017527-ylng1us2	359	104	consensus	consensus	NN
cord-017527-ylng1us2	359	105	guideline	guideline	NN
cord-017527-ylng1us2	359	106	,	,	,
cord-017527-ylng1us2	359	107	quality	quality	NN
cord-017527-ylng1us2	359	108	of	of	IN
cord-017527-ylng1us2	359	109	biotechnological	biotechnological	JJ
cord-017527-ylng1us2	359	110	products	product	NNS
cord-017527-ylng1us2	359	111	:	:	:
cord-017527-ylng1us2	359	112	viral	viral	JJ
cord-017527-ylng1us2	359	113	safety	safety	NN
cord-017527-ylng1us2	359	114	evaluation	evaluation	NN
cord-017527-ylng1us2	359	115	of	of	IN
cord-017527-ylng1us2	359	116	biotechnology	biotechnology	NN
cord-017527-ylng1us2	359	117	products	product	NNS
cord-017527-ylng1us2	359	118	derived	derive	VBN
cord-017527-ylng1us2	359	119	from	from	IN
cord-017527-ylng1us2	359	120	cell	cell	NN
cord-017527-ylng1us2	359	121	lines	line	NNS
cord-017527-ylng1us2	359	122	of	of	IN
cord-017527-ylng1us2	359	123	human	human	JJ
cord-017527-ylng1us2	359	124	or	or	CC
cord-017527-ylng1us2	359	125	animal	animal	NN
cord-017527-ylng1us2	359	126	origin	origin	NN
cord-017527-ylng1us2	359	127	,	,	,
cord-017527-ylng1us2	359	128	CPMP	CPMP	NNP
cord-017527-ylng1us2	359	129	/	/	SYM
cord-017527-ylng1us2	359	130	ICH/295/95	ICH/295/95	NNP
cord-017527-ylng1us2	359	131	.	.	.
cord-017527-ylng1us2	360	1	The	the	DT
cord-017527-ylng1us2	360	2	European	European	NNP
cord-017527-ylng1us2	360	3	Agency	Agency	NNP
cord-017527-ylng1us2	360	4	for	for	IN
cord-017527-ylng1us2	360	5	the	the	DT
cord-017527-ylng1us2	360	6	Evaluation	Evaluation	NNP
cord-017527-ylng1us2	360	7	of	of	IN
cord-017527-ylng1us2	360	8	Medicinal	Medicinal	NNP
cord-017527-ylng1us2	360	9	Products	Products	NNPS
cord-017527-ylng1us2	360	10	,	,	,
cord-017527-ylng1us2	360	11	Human	Human	NNP
cord-017527-ylng1us2	360	12	medicines	medicine	NNS
cord-017527-ylng1us2	360	13	Evaluation	Evaluation	NNP
cord-017527-ylng1us2	360	14	Unit	Unit	NNP
cord-017527-ylng1us2	360	15	Working	Working	NNP
cord-017527-ylng1us2	360	16	safely	safely	RB
cord-017527-ylng1us2	360	17	with	with	IN
cord-017527-ylng1us2	360	18	vaccinia	vaccinia	NN
cord-017527-ylng1us2	360	19	virus	virus	NN
cord-017527-ylng1us2	360	20	:	:	:
cord-017527-ylng1us2	361	1	laboratory	laboratory	NN
cord-017527-ylng1us2	361	2	technique	technique	NN
cord-017527-ylng1us2	361	3	and	and	CC
cord-017527-ylng1us2	361	4	review	review	NN
cord-017527-ylng1us2	361	5	of	of	IN
cord-017527-ylng1us2	361	6	published	publish	VBN
cord-017527-ylng1us2	361	7	cases	case	NNS
cord-017527-ylng1us2	361	8	of	of	IN
cord-017527-ylng1us2	361	9	accidental	accidental	JJ
cord-017527-ylng1us2	361	10	laboratory	laboratory	NN
cord-017527-ylng1us2	361	11	infections	infection	NNS
cord-017527-ylng1us2	361	12	Hiding	hide	VBG
cord-017527-ylng1us2	361	13	in	in	IN
cord-017527-ylng1us2	361	14	plain	plain	JJ
cord-017527-ylng1us2	361	15	view	view	NN
cord-017527-ylng1us2	361	16	:	:	:
cord-017527-ylng1us2	361	17	genetic	genetic	JJ
cord-017527-ylng1us2	361	18	profiling	profiling	NN
cord-017527-ylng1us2	361	19	reveals	reveal	VBZ
cord-017527-ylng1us2	361	20	decades	decade	NNS
cord-017527-ylng1us2	361	21	old	old	JJ
cord-017527-ylng1us2	361	22	cross	cross	JJ
cord-017527-ylng1us2	361	23	contamination	contamination	NN
cord-017527-ylng1us2	361	24	of	of	IN
cord-017527-ylng1us2	361	25	bladder	bladder	NN
cord-017527-ylng1us2	361	26	cancer	cancer	NN
cord-017527-ylng1us2	361	27	cell	cell	NN
cord-017527-ylng1us2	361	28	line	line	NN
cord-017527-ylng1us2	361	29	KU7	KU7	NNP
cord-017527-ylng1us2	361	30	with	with	IN
cord-017527-ylng1us2	361	31	HeLa	HeLa	NNP
cord-017527-ylng1us2	361	32	Cross	Cross	NNP
cord-017527-ylng1us2	361	33	-	-	HYPH
cord-017527-ylng1us2	361	34	contamination	contamination	NN
cord-017527-ylng1us2	361	35	of	of	IN
cord-017527-ylng1us2	361	36	a	a	DT
cord-017527-ylng1us2	361	37	UROtsa	urotsa	CD
cord-017527-ylng1us2	361	38	stock	stock	NN
cord-017527-ylng1us2	361	39	with	with	IN
cord-017527-ylng1us2	361	40	T24	T24	NNP
cord-017527-ylng1us2	361	41	cells	cell	NNS
cord-017527-ylng1us2	361	42	-	-	HYPH
cord-017527-ylng1us2	361	43	molecular	molecular	JJ
cord-017527-ylng1us2	361	44	comparison	comparison	NN
cord-017527-ylng1us2	361	45	of	of	IN
cord-017527-ylng1us2	361	46	different	different	JJ
cord-017527-ylng1us2	361	47	cell	cell	NN
cord-017527-ylng1us2	361	48	lines	line	NNS
cord-017527-ylng1us2	361	49	and	and	CC
cord-017527-ylng1us2	361	50	stocks	stock	NNS
cord-017527-ylng1us2	361	51	Accidental	accidental	JJ
cord-017527-ylng1us2	361	52	human	human	JJ
cord-017527-ylng1us2	361	53	vaccination	vaccination	NN
cord-017527-ylng1us2	361	54	with	with	IN
cord-017527-ylng1us2	361	55	vaccinia	vaccinia	NN
cord-017527-ylng1us2	361	56	virus	virus	NN
cord-017527-ylng1us2	361	57	expressing	express	VBG
cord-017527-ylng1us2	361	58	nucleoprotein	nucleoprotein	NNP
cord-017527-ylng1us2	361	59	gene	gene	NNP
cord-017527-ylng1us2	361	60	Influenza	Influenza	NNP
cord-017527-ylng1us2	361	61	virus	virus	NN
cord-017527-ylng1us2	361	62	inactivation	inactivation	NN
cord-017527-ylng1us2	361	63	for	for	IN
cord-017527-ylng1us2	361	64	studies	study	NNS
cord-017527-ylng1us2	361	65	of	of	IN
cord-017527-ylng1us2	361	66	antigenicity	antigenicity	NN
cord-017527-ylng1us2	361	67	and	and	CC
cord-017527-ylng1us2	361	68	phenotypic	phenotypic	NN
cord-017527-ylng1us2	361	69	neuraminidase	neuraminidase	JJ
cord-017527-ylng1us2	361	70	inhibitor	inhibitor	NN
cord-017527-ylng1us2	361	71	resistance	resistance	NN
cord-017527-ylng1us2	361	72	profiling	profile	VBG
cord-017527-ylng1us2	361	73	Prolonged	prolong	VBN
cord-017527-ylng1us2	361	74	survival	survival	NN
cord-017527-ylng1us2	361	75	of	of	IN
cord-017527-ylng1us2	361	76	Puumala	Puumala	NNP
cord-017527-ylng1us2	361	77	hantavirus	hantavirus	NN
cord-017527-ylng1us2	361	78	outside	outside	IN
cord-017527-ylng1us2	361	79	the	the	DT
cord-017527-ylng1us2	361	80	host	host	NN
cord-017527-ylng1us2	361	81	:	:	:
cord-017527-ylng1us2	361	82	evidence	evidence	NN
cord-017527-ylng1us2	361	83	for	for	IN
cord-017527-ylng1us2	361	84	indirect	indirect	JJ
cord-017527-ylng1us2	361	85	transmission	transmission	NN
cord-017527-ylng1us2	361	86	via	via	IN
cord-017527-ylng1us2	361	87	the	the	DT
cord-017527-ylng1us2	361	88	environment	environment	NN
cord-017527-ylng1us2	362	1	A	a	DT
cord-017527-ylng1us2	362	2	new	new	JJ
cord-017527-ylng1us2	362	3	subtype	subtype	NN
cord-017527-ylng1us2	362	4	of	of	IN
cord-017527-ylng1us2	362	5	human	human	JJ
cord-017527-ylng1us2	362	6	T	t	NN
cord-017527-ylng1us2	362	7	-	-	HYPH
cord-017527-ylng1us2	362	8	cell	cell	NN
cord-017527-ylng1us2	362	9	leukemia	leukemia	NN
cord-017527-ylng1us2	362	10	virus	virus	NN
cord-017527-ylng1us2	362	11	(	(	-LRB-
cord-017527-ylng1us2	362	12	HTLV	HTLV	NNP
cord-017527-ylng1us2	362	13	-	-	HYPH
cord-017527-ylng1us2	362	14	II	II	NNP
cord-017527-ylng1us2	362	15	)	)	-RRB-
cord-017527-ylng1us2	362	16	associated	associate	VBN
cord-017527-ylng1us2	362	17	with	with	IN
cord-017527-ylng1us2	362	18	a	a	DT
cord-017527-ylng1us2	362	19	T	t	NN
cord-017527-ylng1us2	362	20	-	-	HYPH
cord-017527-ylng1us2	362	21	cell	cell	NN
cord-017527-ylng1us2	362	22	variant	variant	NN
cord-017527-ylng1us2	362	23	of	of	IN
cord-017527-ylng1us2	362	24	hairy	hairy	JJ
cord-017527-ylng1us2	362	25	cell	cell	NN
cord-017527-ylng1us2	362	26	leukemia	leukemia	NN
cord-017527-ylng1us2	362	27	A	A	NNP
cord-017527-ylng1us2	362	28	compact	compact	JJ
cord-017527-ylng1us2	362	29	,	,	,
cord-017527-ylng1us2	362	30	automated	automated	JJ
cord-017527-ylng1us2	362	31	cell	cell	NN
cord-017527-ylng1us2	362	32	culture	culture	NN
cord-017527-ylng1us2	362	33	system	system	NN
cord-017527-ylng1us2	362	34	for	for	IN
cord-017527-ylng1us2	362	35	clinical	clinical	JJ
cord-017527-ylng1us2	362	36	scale	scale	NN
cord-017527-ylng1us2	362	37	cell	cell	NN
cord-017527-ylng1us2	362	38	expansion	expansion	NN
cord-017527-ylng1us2	362	39	from	from	IN
cord-017527-ylng1us2	362	40	primary	primary	JJ
cord-017527-ylng1us2	362	41	tissues	tissue	NNS
cord-017527-ylng1us2	363	1	Brief	brief	JJ
cord-017527-ylng1us2	363	2	report	report	NN
cord-017527-ylng1us2	363	3	,	,	,
cord-017527-ylng1us2	363	4	infections	infection	NNS
cord-017527-ylng1us2	363	5	of	of	IN
cord-017527-ylng1us2	363	6	a	a	DT
cord-017527-ylng1us2	363	7	laboratory	laboratory	NN
cord-017527-ylng1us2	363	8	worker	worker	NN
cord-017527-ylng1us2	363	9	with	with	IN
cord-017527-ylng1us2	363	10	simian	simian	JJ
cord-017527-ylng1us2	363	11	immunodeficiency	immunodeficiency	NN
cord-017527-ylng1us2	363	12	virus	virus	NN
cord-017527-ylng1us2	363	13	How	how	WRB
cord-017527-ylng1us2	363	14	long	long	RB
cord-017527-ylng1us2	363	15	do	do	VBP
cord-017527-ylng1us2	363	16	nosocomial	nosocomial	JJ
cord-017527-ylng1us2	363	17	pathogens	pathogen	NNS
cord-017527-ylng1us2	363	18	persist	persist	VB
cord-017527-ylng1us2	363	19	on	on	IN
cord-017527-ylng1us2	363	20	inanimate	inanimate	JJ
cord-017527-ylng1us2	363	21	surfaces	surface	NNS
cord-017527-ylng1us2	363	22	?	?	.
cord-017527-ylng1us2	364	1	A	a	DT
cord-017527-ylng1us2	364	2	systematic	systematic	JJ
cord-017527-ylng1us2	364	3	review	review	NN
cord-017527-ylng1us2	365	1	A	a	DT
cord-017527-ylng1us2	365	2	novel	novel	JJ
cord-017527-ylng1us2	365	3	coronavirus	coronavirus	NN
cord-017527-ylng1us2	365	4	associated	associate	VBN
cord-017527-ylng1us2	365	5	with	with	IN
cord-017527-ylng1us2	365	6	SARS	SARS	NNP
cord-017527-ylng1us2	365	7	Cell	Cell	NNP
cord-017527-ylng1us2	365	8	culture	culture	NN
cord-017527-ylng1us2	365	9	contamination	contamination	NN
cord-017527-ylng1us2	365	10	:	:	:
cord-017527-ylng1us2	365	11	an	an	DT
cord-017527-ylng1us2	365	12	overview	overview	NN
cord-017527-ylng1us2	365	13	Improving	improve	VBG
cord-017527-ylng1us2	365	14	the	the	DT
cord-017527-ylng1us2	365	15	biosafety	biosafety	NN
cord-017527-ylng1us2	365	16	of	of	IN
cord-017527-ylng1us2	365	17	cell	cell	NN
cord-017527-ylng1us2	365	18	sorting	sorting	NN
cord-017527-ylng1us2	365	19	by	by	IN
cord-017527-ylng1us2	365	20	adaptation	adaptation	NN
cord-017527-ylng1us2	365	21	of	of	IN
cord-017527-ylng1us2	365	22	a	a	DT
cord-017527-ylng1us2	365	23	cell	cell	NN
cord-017527-ylng1us2	365	24	sorting	sort	VBG
cord-017527-ylng1us2	365	25	system	system	NN
cord-017527-ylng1us2	365	26	to	to	IN
cord-017527-ylng1us2	365	27	a	a	DT
cord-017527-ylng1us2	365	28	biosafety	biosafety	NN
cord-017527-ylng1us2	365	29	cabinet	cabinet	NN
cord-017527-ylng1us2	365	30	Bovine	bovine	JJ
cord-017527-ylng1us2	365	31	viral	viral	JJ
cord-017527-ylng1us2	365	32	diarrhea	diarrhea	NN
cord-017527-ylng1us2	365	33	virus	virus	NN
cord-017527-ylng1us2	365	34	contamination	contamination	NN
cord-017527-ylng1us2	365	35	of	of	IN
cord-017527-ylng1us2	365	36	nutrient	nutrient	NN
cord-017527-ylng1us2	365	37	serum	serum	NN
cord-017527-ylng1us2	365	38	,	,	,
cord-017527-ylng1us2	365	39	cell	cell	NN
cord-017527-ylng1us2	365	40	cultures	culture	NNS
cord-017527-ylng1us2	365	41	and	and	CC
cord-017527-ylng1us2	365	42	viral	viral	JJ
cord-017527-ylng1us2	365	43	vaccines	vaccine	NNS
cord-017527-ylng1us2	365	44	Ocular	ocular	JJ
cord-017527-ylng1us2	365	45	vaccinia	vaccinia	NN
cord-017527-ylng1us2	365	46	infection	infection	NN
cord-017527-ylng1us2	365	47	in	in	IN
cord-017527-ylng1us2	365	48	laboratory	laboratory	NN
cord-017527-ylng1us2	365	49	worker	worker	NN
cord-017527-ylng1us2	365	50	A	a	DT
cord-017527-ylng1us2	365	51	tale	tale	NN
cord-017527-ylng1us2	365	52	of	of	IN
cord-017527-ylng1us2	365	53	two	two	CD
cord-017527-ylng1us2	365	54	clades	clade	NNS
cord-017527-ylng1us2	365	55	:	:	:
cord-017527-ylng1us2	365	56	monkeypox	monkeypox	NN
cord-017527-ylng1us2	365	57	viruses	virus	NNS
cord-017527-ylng1us2	365	58	Molecular	molecular	JJ
cord-017527-ylng1us2	365	59	cloning	clone	VBG
cord-017527-ylng1us2	365	60	and	and	CC
cord-017527-ylng1us2	365	61	disease	disease	NNP
cord-017527-ylng1us2	365	62	association	association	NNP
cord-017527-ylng1us2	365	63	of	of	IN
cord-017527-ylng1us2	365	64	hepatitis	hepatitis	NNP
cord-017527-ylng1us2	365	65	G	G	NNP
cord-017527-ylng1us2	365	66	virus	virus	NN
cord-017527-ylng1us2	365	67	:	:	:
cord-017527-ylng1us2	365	68	a	a	DT
cord-017527-ylng1us2	365	69	transfusion	transfusion	NN
cord-017527-ylng1us2	365	70	-	-	HYPH
cord-017527-ylng1us2	365	71	transmissible	transmissible	JJ
cord-017527-ylng1us2	365	72	agent	agent	NN
cord-017527-ylng1us2	365	73	Infection	infection	NN
cord-017527-ylng1us2	365	74	of	of	IN
cord-017527-ylng1us2	365	75	laboratory	laboratory	NN
cord-017527-ylng1us2	365	76	workers	worker	NNS
cord-017527-ylng1us2	365	77	with	with	IN
cord-017527-ylng1us2	365	78	hantavirus	hantavirus	NN
cord-017527-ylng1us2	365	79	acquired	acquire	VBN
cord-017527-ylng1us2	365	80	from	from	IN
cord-017527-ylng1us2	365	81	immunocytomas	immunocytomas	NNP
cord-017527-ylng1us2	365	82	propagated	propagate	VBN
cord-017527-ylng1us2	365	83	in	in	IN
cord-017527-ylng1us2	365	84	laboratory	laboratory	NN
cord-017527-ylng1us2	365	85	rats	rat	NNS
cord-017527-ylng1us2	365	86	Cross	Cross	NNP
cord-017527-ylng1us2	365	87	-	-	HYPH
cord-017527-ylng1us2	365	88	species	species	JJ
cord-017527-ylng1us2	365	89	transfer	transfer	NN
cord-017527-ylng1us2	365	90	of	of	IN
cord-017527-ylng1us2	365	91	viruses	virus	NNS
cord-017527-ylng1us2	365	92	:	:	:
cord-017527-ylng1us2	365	93	implications	implication	NNS
cord-017527-ylng1us2	365	94	for	for	IN
cord-017527-ylng1us2	365	95	the	the	DT
cord-017527-ylng1us2	365	96	use	use	NN
cord-017527-ylng1us2	365	97	of	of	IN
cord-017527-ylng1us2	365	98	viral	viral	JJ
cord-017527-ylng1us2	365	99	vectors	vector	NNS
cord-017527-ylng1us2	365	100	in	in	IN
cord-017527-ylng1us2	365	101	biomedical	biomedical	JJ
cord-017527-ylng1us2	365	102	research	research	NN
cord-017527-ylng1us2	365	103	,	,	,
cord-017527-ylng1us2	365	104	gene	gene	NN
cord-017527-ylng1us2	365	105	therapy	therapy	NN
cord-017527-ylng1us2	365	106	and	and	CC
cord-017527-ylng1us2	365	107	as	as	IN
cord-017527-ylng1us2	365	108	live	live	NN
cord-017527-ylng1us2	365	109	-	-	HYPH
cord-017527-ylng1us2	365	110	virus	virus	NN
cord-017527-ylng1us2	365	111	vaccines	vaccine	NNS
cord-017527-ylng1us2	365	112	Henrietta	Henrietta	NNP
cord-017527-ylng1us2	365	113	Lacks	lack	VBZ
cord-017527-ylng1us2	365	114	,	,	,
cord-017527-ylng1us2	365	115	HeLa	HeLa	NNP
cord-017527-ylng1us2	365	116	cells	cell	NNS
cord-017527-ylng1us2	365	117	,	,	,
cord-017527-ylng1us2	365	118	and	and	CC
cord-017527-ylng1us2	365	119	cell	cell	NN
cord-017527-ylng1us2	365	120	culture	culture	NN
cord-017527-ylng1us2	365	121	contamination	contamination	NN
cord-017527-ylng1us2	365	122	CD4-independent	cd4-independent	NN
cord-017527-ylng1us2	365	123	infection	infection	NN
cord-017527-ylng1us2	365	124	by	by	IN
cord-017527-ylng1us2	365	125	human	human	JJ
cord-017527-ylng1us2	365	126	immunodeficiency	immunodeficiency	NN
cord-017527-ylng1us2	365	127	virus	virus	NN
cord-017527-ylng1us2	365	128	type	type	NN
cord-017527-ylng1us2	365	129	I	-PRON-	PRP
cord-017527-ylng1us2	365	130	after	after	IN
cord-017527-ylng1us2	365	131	phenotypic	phenotypic	NN
cord-017527-ylng1us2	365	132	mixing	mix	VBG
cord-017527-ylng1us2	365	133	with	with	IN
cord-017527-ylng1us2	365	134	human	human	JJ
cord-017527-ylng1us2	365	135	T	t	NN
cord-017527-ylng1us2	365	136	-	-	HYPH
cord-017527-ylng1us2	365	137	cell	cell	NN
cord-017527-ylng1us2	365	138	leukemia	leukemia	NN
cord-017527-ylng1us2	365	139	viruses	virus	NNS
cord-017527-ylng1us2	365	140	Where	where	WRB
cord-017527-ylng1us2	365	141	all	all	PDT
cord-017527-ylng1us2	365	142	the	the	DT
cord-017527-ylng1us2	365	143	cell	cell	NN
cord-017527-ylng1us2	365	144	lines	line	NNS
cord-017527-ylng1us2	365	145	gone	go	VBN
cord-017527-ylng1us2	365	146	?	?	.
cord-017527-ylng1us2	366	1	Zoonosis	zoonosis	NN
cord-017527-ylng1us2	366	2	and	and	CC
cord-017527-ylng1us2	366	3	haemorrhagic	haemorrhagic	JJ
cord-017527-ylng1us2	366	4	fever	fever	NN
cord-017527-ylng1us2	366	5	Emerging	emerge	VBG
cord-017527-ylng1us2	366	6	zoonoses	zoonosis	NNS
cord-017527-ylng1us2	366	7	:	:	:
cord-017527-ylng1us2	366	8	crossing	cross	VBG
cord-017527-ylng1us2	366	9	the	the	DT
cord-017527-ylng1us2	366	10	species	specie	NNS
cord-017527-ylng1us2	366	11	barrier	barrier	NN
cord-017527-ylng1us2	366	12	Virus	Virus	NNP
cord-017527-ylng1us2	366	13	zoonoses	zoonosis	NNS
cord-017527-ylng1us2	366	14	and	and	CC
cord-017527-ylng1us2	366	15	their	-PRON-	PRP$
cord-017527-ylng1us2	366	16	potential	potential	NN
cord-017527-ylng1us2	366	17	for	for	IN
cord-017527-ylng1us2	366	18	contamination	contamination	NN
cord-017527-ylng1us2	366	19	of	of	IN
cord-017527-ylng1us2	366	20	cell	cell	NN
cord-017527-ylng1us2	366	21	cultures	culture	NNS
cord-017527-ylng1us2	366	22	Efficient	efficient	JJ
cord-017527-ylng1us2	366	23	DNA	dna	NN
cord-017527-ylng1us2	366	24	fingerprinting	fingerprinting	NN
cord-017527-ylng1us2	366	25	method	method	NN
cord-017527-ylng1us2	366	26	for	for	IN
cord-017527-ylng1us2	366	27	the	the	DT
cord-017527-ylng1us2	366	28	identification	identification	NN
cord-017527-ylng1us2	366	29	of	of	IN
cord-017527-ylng1us2	366	30	cross	cross	JJ
cord-017527-ylng1us2	366	31	-	-	JJ
cord-017527-ylng1us2	366	32	culture	culture	JJ
cord-017527-ylng1us2	366	33	contamination	contamination	NN
cord-017527-ylng1us2	366	34	of	of	IN
cord-017527-ylng1us2	366	35	cell	cell	NN
cord-017527-ylng1us2	366	36	lines	line	NNS
cord-017527-ylng1us2	366	37	Dense	dense	JJ
cord-017527-ylng1us2	366	38	display	display	NN
cord-017527-ylng1us2	366	39	of	of	IN
cord-017527-ylng1us2	366	40	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	366	41	envelope	envelope	NN
cord-017527-ylng1us2	366	42	spikes	spike	NNS
cord-017527-ylng1us2	366	43	on	on	IN
cord-017527-ylng1us2	366	44	the	the	DT
cord-017527-ylng1us2	366	45	lambda	lambda	NN
cord-017527-ylng1us2	366	46	phage	phage	NN
cord-017527-ylng1us2	366	47	scaffold	scaffold	NN
cord-017527-ylng1us2	366	48	does	do	VBZ
cord-017527-ylng1us2	366	49	not	not	RB
cord-017527-ylng1us2	366	50	result	result	VB
cord-017527-ylng1us2	366	51	in	in	IN
cord-017527-ylng1us2	366	52	the	the	DT
cord-017527-ylng1us2	366	53	generation	generation	NN
cord-017527-ylng1us2	366	54	of	of	IN
cord-017527-ylng1us2	366	55	improved	improve	VBN
cord-017527-ylng1us2	366	56	antibody	antibody	NN
cord-017527-ylng1us2	366	57	response	response	NN
cord-017527-ylng1us2	366	58	to	to	IN
cord-017527-ylng1us2	366	59	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	366	60	Env	Env	NNP
cord-017527-ylng1us2	366	61	Spread	Spread	NNP
cord-017527-ylng1us2	366	62	and	and	CC
cord-017527-ylng1us2	366	63	control	control	NN
cord-017527-ylng1us2	366	64	of	of	IN
cord-017527-ylng1us2	366	65	mycoplasmal	mycoplasmal	JJ
cord-017527-ylng1us2	366	66	infection	infection	NN
cord-017527-ylng1us2	366	67	of	of	IN
cord-017527-ylng1us2	366	68	cell	cell	NN
cord-017527-ylng1us2	366	69	cultures	culture	NNS
cord-017527-ylng1us2	366	70	Cell	cell	NN
cord-017527-ylng1us2	366	71	culture	culture	NN
cord-017527-ylng1us2	367	1	mycoplasmas	mycoplasmas	NNP
cord-017527-ylng1us2	367	2	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	367	3	acquired	acquire	VBD
cord-017527-ylng1us2	367	4	infection	infection	NN
cord-017527-ylng1us2	367	5	with	with	IN
cord-017527-ylng1us2	367	6	recombinant	recombinant	JJ
cord-017527-ylng1us2	367	7	vaccinia	vaccinia	NN
cord-017527-ylng1us2	367	8	virus	virus	NN
cord-017527-ylng1us2	367	9	containing	contain	VBG
cord-017527-ylng1us2	367	10	an	an	DT
cord-017527-ylng1us2	367	11	immunomodulating	immunomodulate	VBG
cord-017527-ylng1us2	367	12	construct	construct	NN
cord-017527-ylng1us2	367	13	Microbial	microbial	JJ
cord-017527-ylng1us2	367	14	contamination	contamination	NN
cord-017527-ylng1us2	367	15	of	of	IN
cord-017527-ylng1us2	367	16	cell	cell	NN
cord-017527-ylng1us2	367	17	cultures	culture	NNS
cord-017527-ylng1us2	367	18	:	:	:
cord-017527-ylng1us2	367	19	a	a	DT
cord-017527-ylng1us2	367	20	2	2	CD
cord-017527-ylng1us2	367	21	years	year	NNS
cord-017527-ylng1us2	367	22	study	study	VBP
cord-017527-ylng1us2	367	23	Primary	primary	JJ
cord-017527-ylng1us2	367	24	characterization	characterization	NN
cord-017527-ylng1us2	367	25	of	of	IN
cord-017527-ylng1us2	367	26	a	a	DT
cord-017527-ylng1us2	367	27	herpesvirus	herpesvirus	NN
cord-017527-ylng1us2	367	28	agent	agent	NN
cord-017527-ylng1us2	367	29	associated	associate	VBN
cord-017527-ylng1us2	367	30	with	with	IN
cord-017527-ylng1us2	367	31	Kaposi	Kaposi	NNP
cord-017527-ylng1us2	367	32	's	's	POS
cord-017527-ylng1us2	367	33	sarcoma	sarcoma	NN
cord-017527-ylng1us2	367	34	Accidental	accidental	JJ
cord-017527-ylng1us2	367	35	infection	infection	NN
cord-017527-ylng1us2	367	36	of	of	IN
cord-017527-ylng1us2	367	37	laboratory	laboratory	NN
cord-017527-ylng1us2	367	38	worker	worker	NN
cord-017527-ylng1us2	367	39	with	with	IN
cord-017527-ylng1us2	367	40	vaccinia	vaccinia	NNP
cord-017527-ylng1us2	367	41	virus	virus	NN
cord-017527-ylng1us2	367	42	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	367	43	safety	safety	NN
cord-017527-ylng1us2	367	44	monograph	monograph	NN
cord-017527-ylng1us2	367	45	:	:	:
cord-017527-ylng1us2	367	46	a	a	DT
cord-017527-ylng1us2	367	47	supplement	supplement	NN
cord-017527-ylng1us2	367	48	to	to	IN
cord-017527-ylng1us2	367	49	the	the	DT
cord-017527-ylng1us2	367	50	NIH	NIH	NNP
cord-017527-ylng1us2	367	51	guidelines	guideline	NNS
cord-017527-ylng1us2	367	52	for	for	IN
cord-017527-ylng1us2	367	53	recombinant	recombinant	JJ
cord-017527-ylng1us2	367	54	DNA	dna	NN
cord-017527-ylng1us2	367	55	research	research	NN
cord-017527-ylng1us2	367	56	.	.	.
cord-017527-ylng1us2	368	1	National	National	NNP
cord-017527-ylng1us2	368	2	Institute	Institute	NNP
cord-017527-ylng1us2	368	3	of	of	IN
cord-017527-ylng1us2	368	4	Health	Health	NNP
cord-017527-ylng1us2	368	5	A	A	NNP
cord-017527-ylng1us2	368	6	Novel	Novel	NNP
cord-017527-ylng1us2	368	7	DNA	dna	NN
cord-017527-ylng1us2	368	8	virus	virus	NN
cord-017527-ylng1us2	368	9	(	(	-LRB-
cord-017527-ylng1us2	368	10	TTV	TTV	NNP
cord-017527-ylng1us2	368	11	)	)	-RRB-
cord-017527-ylng1us2	368	12	associated	associate	VBN
cord-017527-ylng1us2	368	13	with	with	IN
cord-017527-ylng1us2	368	14	elevated	elevated	JJ
cord-017527-ylng1us2	368	15	transaminase	transaminase	NN
cord-017527-ylng1us2	368	16	levels	level	NNS
cord-017527-ylng1us2	368	17	in	in	IN
cord-017527-ylng1us2	368	18	posttransfusion	posttransfusion	NN
cord-017527-ylng1us2	368	19	hepatitis	hepatitis	NN
cord-017527-ylng1us2	368	20	of	of	IN
cord-017527-ylng1us2	368	21	unknown	unknown	JJ
cord-017527-ylng1us2	368	22	etiology	etiology	NN
cord-017527-ylng1us2	368	23	Aerosols	aerosol	NNS
cord-017527-ylng1us2	368	24	as	as	IN
cord-017527-ylng1us2	368	25	a	a	DT
cord-017527-ylng1us2	368	26	source	source	NN
cord-017527-ylng1us2	368	27	of	of	IN
cord-017527-ylng1us2	368	28	widespread	widespread	JJ
cord-017527-ylng1us2	368	29	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	368	30	contamination	contamination	NN
cord-017527-ylng1us2	368	31	of	of	IN
cord-017527-ylng1us2	368	32	tissue	tissue	NN
cord-017527-ylng1us2	368	33	cultures	culture	NNS
cord-017527-ylng1us2	368	34	Accidental	accidental	JJ
cord-017527-ylng1us2	368	35	infections	infection	NNS
cord-017527-ylng1us2	368	36	of	of	IN
cord-017527-ylng1us2	368	37	laboratory	laboratory	NN
cord-017527-ylng1us2	368	38	worker	worker	NN
cord-017527-ylng1us2	368	39	with	with	IN
cord-017527-ylng1us2	368	40	recombinant	recombinant	JJ
cord-017527-ylng1us2	368	41	vaccinia	vaccinia	NN
cord-017527-ylng1us2	368	42	virus	virus	NN
cord-017527-ylng1us2	368	43	Internucleosomal	Internucleosomal	NNP
cord-017527-ylng1us2	368	44	DNA	DNA	NNP
cord-017527-ylng1us2	368	45	fragmentation	fragmentation	NN
cord-017527-ylng1us2	368	46	in	in	IN
cord-017527-ylng1us2	368	47	cultured	cultured	JJ
cord-017527-ylng1us2	368	48	cells	cell	NNS
cord-017527-ylng1us2	368	49	under	under	IN
cord-017527-ylng1us2	368	50	conditions	condition	NNS
cord-017527-ylng1us2	368	51	reported	report	VBN
cord-017527-ylng1us2	368	52	to	to	TO
cord-017527-ylng1us2	368	53	induce	induce	VB
cord-017527-ylng1us2	368	54	apoptosis	apoptosis	NN
cord-017527-ylng1us2	368	55	may	may	MD
cord-017527-ylng1us2	368	56	be	be	VB
cord-017527-ylng1us2	368	57	caused	cause	VBN
cord-017527-ylng1us2	368	58	by	by	IN
cord-017527-ylng1us2	368	59	mycoplasma	mycoplasma	NN
cord-017527-ylng1us2	368	60	endonucleases	endonuclease	NNS
cord-017527-ylng1us2	368	61	Animal	animal	JJ
cord-017527-ylng1us2	368	62	cell	cell	NN
cord-017527-ylng1us2	368	63	cultures	culture	NNS
cord-017527-ylng1us2	368	64	:	:	:
cord-017527-ylng1us2	368	65	risk	risk	NN
cord-017527-ylng1us2	368	66	assessment	assessment	NN
cord-017527-ylng1us2	368	67	and	and	CC
cord-017527-ylng1us2	368	68	biosafety	biosafety	NN
cord-017527-ylng1us2	368	69	recommendations	recommendation	NNS
cord-017527-ylng1us2	369	1	Standard	standard	JJ
cord-017527-ylng1us2	369	2	practice	practice	NN
cord-017527-ylng1us2	369	3	for	for	IN
cord-017527-ylng1us2	369	4	cell	cell	NN
cord-017527-ylng1us2	369	5	sorting	sorting	NN
cord-017527-ylng1us2	369	6	in	in	IN
cord-017527-ylng1us2	369	7	a	a	DT
cord-017527-ylng1us2	369	8	BSL-3	BSL-3	NNP
cord-017527-ylng1us2	369	9	facility	facility	NN
cord-017527-ylng1us2	369	10	Filovirus	Filovirus	NNP
cord-017527-ylng1us2	369	11	contamination	contamination	NN
cord-017527-ylng1us2	369	12	of	of	IN
cord-017527-ylng1us2	369	13	cell	cell	NN
cord-017527-ylng1us2	369	14	cultures	culture	NNS
cord-017527-ylng1us2	369	15	Detection	detection	NN
cord-017527-ylng1us2	369	16	of	of	IN
cord-017527-ylng1us2	369	17	contaminants	contaminant	NNS
cord-017527-ylng1us2	369	18	in	in	IN
cord-017527-ylng1us2	369	19	cell	cell	NN
cord-017527-ylng1us2	369	20	cultures	culture	NNS
cord-017527-ylng1us2	369	21	,	,	,
cord-017527-ylng1us2	369	22	sera	sera	NNP
cord-017527-ylng1us2	369	23	and	and	CC
cord-017527-ylng1us2	369	24	trypsin	trypsin	NNP
cord-017527-ylng1us2	369	25	Detection	detection	NN
cord-017527-ylng1us2	369	26	and	and	CC
cord-017527-ylng1us2	369	27	isolation	isolation	NN
cord-017527-ylng1us2	369	28	of	of	IN
cord-017527-ylng1us2	369	29	type	type	NN
cord-017527-ylng1us2	369	30	C	c	NN
cord-017527-ylng1us2	369	31	retrovirus	retrovirus	NN
cord-017527-ylng1us2	369	32	particles	particle	NNS
cord-017527-ylng1us2	369	33	from	from	IN
cord-017527-ylng1us2	369	34	fresh	fresh	JJ
cord-017527-ylng1us2	369	35	and	and	CC
cord-017527-ylng1us2	369	36	cultured	cultured	JJ
cord-017527-ylng1us2	369	37	lymphocytes	lymphocyte	NNS
cord-017527-ylng1us2	369	38	of	of	IN
cord-017527-ylng1us2	369	39	a	a	DT
cord-017527-ylng1us2	369	40	patient	patient	NN
cord-017527-ylng1us2	369	41	with	with	IN
cord-017527-ylng1us2	369	42	cutaneous	cutaneous	JJ
cord-017527-ylng1us2	369	43	T	t	NN
cord-017527-ylng1us2	369	44	-	-	HYPH
cord-017527-ylng1us2	369	45	cell	cell	NN
cord-017527-ylng1us2	369	46	lymphoma	lymphoma	NN
cord-017527-ylng1us2	369	47	Detection	detection	NN
cord-017527-ylng1us2	369	48	,	,	,
cord-017527-ylng1us2	369	49	isolation	isolation	NN
cord-017527-ylng1us2	369	50	,	,	,
cord-017527-ylng1us2	369	51	and	and	CC
cord-017527-ylng1us2	369	52	continuous	continuous	JJ
cord-017527-ylng1us2	369	53	production	production	NN
cord-017527-ylng1us2	369	54	of	of	IN
cord-017527-ylng1us2	369	55	cytopathic	cytopathic	JJ
cord-017527-ylng1us2	369	56	retroviruses	retrovirus	NNS
cord-017527-ylng1us2	369	57	(	(	-LRB-
cord-017527-ylng1us2	369	58	HTLV	HTLV	NNP
cord-017527-ylng1us2	369	59	-	-	HYPH
cord-017527-ylng1us2	369	60	III	III	NNP
cord-017527-ylng1us2	369	61	)	)	-RRB-
cord-017527-ylng1us2	369	62	from	from	IN
cord-017527-ylng1us2	369	63	patients	patient	NNS
cord-017527-ylng1us2	369	64	with	with	IN
cord-017527-ylng1us2	369	65	AIDS	AIDS	NNP
cord-017527-ylng1us2	369	66	and	and	CC
cord-017527-ylng1us2	369	67	pre	pre	JJ
cord-017527-ylng1us2	369	68	-	-	JJ
cord-017527-ylng1us2	369	69	AIDS	AIDS	NNP
cord-017527-ylng1us2	369	70	Molecular	Molecular	NNP
cord-017527-ylng1us2	369	71	and	and	CC
cord-017527-ylng1us2	369	72	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	369	73	procedures	procedure	NNS
cord-017527-ylng1us2	369	74	in	in	IN
cord-017527-ylng1us2	369	75	mycoplasmology	mycoplasmology	NN
cord-017527-ylng1us2	369	76	Adaptative	Adaptative	NNP
cord-017527-ylng1us2	369	77	pathways	pathway	NNS
cord-017527-ylng1us2	369	78	of	of	IN
cord-017527-ylng1us2	369	79	zoonotic	zoonotic	JJ
cord-017527-ylng1us2	369	80	influenza	influenza	NN
cord-017527-ylng1us2	369	81	viruses	virus	NNS
cord-017527-ylng1us2	369	82	:	:	:
cord-017527-ylng1us2	369	83	from	from	IN
cord-017527-ylng1us2	369	84	exposure	exposure	NN
cord-017527-ylng1us2	369	85	to	to	IN
cord-017527-ylng1us2	369	86	establishment	establishment	NN
cord-017527-ylng1us2	369	87	in	in	IN
cord-017527-ylng1us2	369	88	humans	human	NNS
cord-017527-ylng1us2	370	1	How	how	WRB
cord-017527-ylng1us2	370	2	to	to	TO
cord-017527-ylng1us2	370	3	develop	develop	VB
cord-017527-ylng1us2	370	4	a	a	DT
cord-017527-ylng1us2	370	5	standard	standard	JJ
cord-017527-ylng1us2	370	6	operating	operating	NN
cord-017527-ylng1us2	370	7	procedure	procedure	NN
cord-017527-ylng1us2	370	8	for	for	IN
cord-017527-ylng1us2	370	9	sorting	sort	VBG
cord-017527-ylng1us2	370	10	unfixed	unfixed	JJ
cord-017527-ylng1us2	370	11	cells	cell	NNS
cord-017527-ylng1us2	371	1	An	an	DT
cord-017527-ylng1us2	371	2	automated	automate	VBN
cord-017527-ylng1us2	371	3	HIV-1	HIV-1	NNP
cord-017527-ylng1us2	371	4	Env	Env	NNP
cord-017527-ylng1us2	371	5	-	-	HYPH
cord-017527-ylng1us2	371	6	pseudotyped	pseudotyped	NNP
cord-017527-ylng1us2	371	7	virus	virus	NN
cord-017527-ylng1us2	371	8	production	production	NN
cord-017527-ylng1us2	371	9	for	for	IN
cord-017527-ylng1us2	371	10	global	global	JJ
cord-017527-ylng1us2	371	11	HIV	HIV	NNP
cord-017527-ylng1us2	371	12	vaccine	vaccine	NN
cord-017527-ylng1us2	371	13	trials	trial	NNS
cord-017527-ylng1us2	371	14	Marburg	Marburg	NNP
cord-017527-ylng1us2	371	15	and	and	CC
cord-017527-ylng1us2	371	16	Ebola	Ebola	NNP
cord-017527-ylng1us2	371	17	virus	virus	NN
cord-017527-ylng1us2	371	18	infections	infection	NNS
cord-017527-ylng1us2	371	19	in	in	IN
cord-017527-ylng1us2	371	20	laboratory	laboratory	NN
cord-017527-ylng1us2	371	21	non	non	JJ
cord-017527-ylng1us2	371	22	-	-	JJ
cord-017527-ylng1us2	371	23	human	human	JJ
cord-017527-ylng1us2	371	24	primates	primate	NNS
cord-017527-ylng1us2	371	25	:	:	:
cord-017527-ylng1us2	372	1	a	a	DT
cord-017527-ylng1us2	372	2	literature	literature	NN
cord-017527-ylng1us2	372	3	review	review	NN
cord-017527-ylng1us2	372	4	The	the	DT
cord-017527-ylng1us2	372	5	origin	origin	NN
cord-017527-ylng1us2	372	6	and	and	CC
cord-017527-ylng1us2	372	7	evolution	evolution	NN
cord-017527-ylng1us2	372	8	of	of	IN
cord-017527-ylng1us2	372	9	hepatitis	hepatitis	NN
cord-017527-ylng1us2	372	10	viruses	virus	NNS
cord-017527-ylng1us2	372	11	in	in	IN
cord-017527-ylng1us2	372	12	humans	human	NNS
cord-017527-ylng1us2	372	13	Prion	Prion	NNP
cord-017527-ylng1us2	372	14	propagation	propagation	NN
cord-017527-ylng1us2	372	15	in	in	IN
cord-017527-ylng1us2	372	16	cultured	cultured	JJ
cord-017527-ylng1us2	372	17	cells	cell	NNS
cord-017527-ylng1us2	373	1	Unintended	unintended	JJ
cord-017527-ylng1us2	373	2	spread	spread	NN
cord-017527-ylng1us2	373	3	of	of	IN
cord-017527-ylng1us2	373	4	a	a	DT
cord-017527-ylng1us2	373	5	biosafety	biosafety	NN
cord-017527-ylng1us2	373	6	level	level	NN
cord-017527-ylng1us2	373	7	2	2	CD
cord-017527-ylng1us2	373	8	recombinant	recombinant	JJ
cord-017527-ylng1us2	373	9	retrovirus	retrovirus	NN
cord-017527-ylng1us2	373	10	Aerosols	Aerosols	NNPS
cord-017527-ylng1us2	373	11	:	:	:
cord-017527-ylng1us2	373	12	an	an	DT
cord-017527-ylng1us2	373	13	underestimated	underestimated	JJ
cord-017527-ylng1us2	373	14	vehicle	vehicle	NN
cord-017527-ylng1us2	373	15	for	for	IN
cord-017527-ylng1us2	373	16	transmission	transmission	NN
cord-017527-ylng1us2	373	17	of	of	IN
cord-017527-ylng1us2	373	18	prion	prion	NN
cord-017527-ylng1us2	373	19	diseases	disease	NNS
cord-017527-ylng1us2	374	1	The	the	DT
cord-017527-ylng1us2	374	2	embryonic	embryonic	JJ
cord-017527-ylng1us2	374	3	environment	environment	NN
cord-017527-ylng1us2	374	4	strongly	strongly	RB
cord-017527-ylng1us2	374	5	attenuates	attenuate	VBZ
cord-017527-ylng1us2	374	6	v	v	LS
cord-017527-ylng1us2	374	7	-	-	HYPH
cord-017527-ylng1us2	374	8	src	src	NNP
cord-017527-ylng1us2	374	9	oncogenesis	oncogenesis	NNP
cord-017527-ylng1us2	374	10	in	in	IN
cord-017527-ylng1us2	374	11	mesenchymal	mesenchymal	JJ
cord-017527-ylng1us2	374	12	and	and	CC
cord-017527-ylng1us2	374	13	epithelial	epithelial	JJ
cord-017527-ylng1us2	374	14	tissues	tissue	NNS
cord-017527-ylng1us2	374	15	,	,	,
cord-017527-ylng1us2	374	16	but	but	CC
cord-017527-ylng1us2	374	17	not	not	RB
cord-017527-ylng1us2	374	18	in	in	IN
cord-017527-ylng1us2	374	19	endothelia	endothelia	NNP
cord-017527-ylng1us2	375	1	Kaposi	Kaposi	NNP
cord-017527-ylng1us2	375	2	's	's	POS
cord-017527-ylng1us2	375	3	sarcoma	sarcoma	NN
cord-017527-ylng1us2	375	4	-	-	HYPH
cord-017527-ylng1us2	375	5	derived	derive	VBN
cord-017527-ylng1us2	375	6	cell	cell	NN
cord-017527-ylng1us2	375	7	line	line	NN
cord-017527-ylng1us2	375	8	SLK	SLK	NNP
cord-017527-ylng1us2	375	9	is	be	VBZ
cord-017527-ylng1us2	375	10	not	not	RB
cord-017527-ylng1us2	375	11	of	of	IN
cord-017527-ylng1us2	375	12	endothelial	endothelial	JJ
cord-017527-ylng1us2	375	13	origin	origin	NN
cord-017527-ylng1us2	375	14	,	,	,
cord-017527-ylng1us2	375	15	but	but	CC
cord-017527-ylng1us2	375	16	is	be	VBZ
cord-017527-ylng1us2	375	17	a	a	DT
cord-017527-ylng1us2	375	18	contaminant	contaminant	NN
cord-017527-ylng1us2	375	19	from	from	IN
cord-017527-ylng1us2	375	20	a	a	DT
cord-017527-ylng1us2	375	21	known	know	VBN
cord-017527-ylng1us2	375	22	renal	renal	JJ
cord-017527-ylng1us2	375	23	carcinoma	carcinoma	NN
cord-017527-ylng1us2	375	24	cell	cell	NN
cord-017527-ylng1us2	375	25	line	line	NN
cord-017527-ylng1us2	375	26	Classification	classification	NN
cord-017527-ylng1us2	375	27	of	of	IN
cord-017527-ylng1us2	375	28	organisms	organism	NNS
cord-017527-ylng1us2	375	29	Recommendation	Recommendation	NNP
cord-017527-ylng1us2	375	30	on	on	IN
cord-017527-ylng1us2	375	31	the	the	DT
cord-017527-ylng1us2	375	32	safe	safe	JJ
cord-017527-ylng1us2	375	33	handling	handling	NN
cord-017527-ylng1us2	375	34	of	of	IN
cord-017527-ylng1us2	375	35	human	human	JJ
cord-017527-ylng1us2	375	36	and	and	CC
cord-017527-ylng1us2	375	37	animal	animal	NN
cord-017527-ylng1us2	375	38	cells	cell	NNS
cord-017527-ylng1us2	375	39	and	and	CC
cord-017527-ylng1us2	375	40	cell	cell	NN
cord-017527-ylng1us2	375	41	cultures	culture	NNS
cord-017527-ylng1us2	375	42	Automated	automate	VBN
cord-017527-ylng1us2	375	43	adherent	adherent	JJ
cord-017527-ylng1us2	375	44	human	human	JJ
cord-017527-ylng1us2	375	45	cell	cell	NN
cord-017527-ylng1us2	375	46	culture	culture	NN
cord-017527-ylng1us2	375	47	(	(	-LRB-
cord-017527-ylng1us2	375	48	mesenchymal	mesenchymal	JJ
cord-017527-ylng1us2	375	49	stem	stem	NN
cord-017527-ylng1us2	375	50	cells	cell	NNS
cord-017527-ylng1us2	375	51	)	)	-RRB-
cord-017527-ylng1us2	376	1	Environmental	environmental	JJ
cord-017527-ylng1us2	376	2	risk	risk	NN
cord-017527-ylng1us2	376	3	assessment	assessment	NN
cord-017527-ylng1us2	376	4	of	of	IN
cord-017527-ylng1us2	376	5	replication	replication	NN
cord-017527-ylng1us2	376	6	competent	competent	JJ
cord-017527-ylng1us2	376	7	viral	viral	JJ
cord-017527-ylng1us2	376	8	vectors	vector	NNS
cord-017527-ylng1us2	376	9	applied	apply	VBN
cord-017527-ylng1us2	376	10	in	in	IN
cord-017527-ylng1us2	376	11	clinical	clinical	JJ
cord-017527-ylng1us2	376	12	trials	trial	NNS
cord-017527-ylng1us2	376	13	:	:	:
cord-017527-ylng1us2	376	14	potential	potential	JJ
cord-017527-ylng1us2	376	15	effects	effect	NNS
cord-017527-ylng1us2	376	16	of	of	IN
cord-017527-ylng1us2	376	17	inserted	insert	VBN
cord-017527-ylng1us2	376	18	sequences	sequence	NNS
cord-017527-ylng1us2	376	19	A	a	DT
cord-017527-ylng1us2	376	20	newly	newly	RB
cord-017527-ylng1us2	376	21	discovered	discover	VBN
cord-017527-ylng1us2	376	22	human	human	JJ
cord-017527-ylng1us2	376	23	pneumovirus	pneumovirus	NNP
cord-017527-ylng1us2	376	24	isolated	isolate	VBN
cord-017527-ylng1us2	376	25	from	from	IN
cord-017527-ylng1us2	376	26	young	young	JJ
cord-017527-ylng1us2	376	27	children	child	NNS
cord-017527-ylng1us2	376	28	with	with	IN
cord-017527-ylng1us2	376	29	respiratory	respiratory	JJ
cord-017527-ylng1us2	376	30	tract	tract	NN
cord-017527-ylng1us2	376	31	disease	disease	NN
cord-017527-ylng1us2	376	32	Persistent	persistent	JJ
cord-017527-ylng1us2	376	33	infection	infection	NN
cord-017527-ylng1us2	376	34	of	of	IN
cord-017527-ylng1us2	376	35	some	some	DT
cord-017527-ylng1us2	376	36	standard	standard	JJ
cord-017527-ylng1us2	376	37	cell	cell	NN
cord-017527-ylng1us2	376	38	lines	line	NNS
cord-017527-ylng1us2	376	39	by	by	IN
cord-017527-ylng1us2	376	40	lymphocytic	lymphocytic	JJ
cord-017527-ylng1us2	376	41	choriomeningitis	choriomeningitis	NNP
cord-017527-ylng1us2	376	42	virus	virus	NN
cord-017527-ylng1us2	376	43	:	:	:
cord-017527-ylng1us2	376	44	transmission	transmission	NN
cord-017527-ylng1us2	376	45	of	of	IN
cord-017527-ylng1us2	376	46	infection	infection	NN
cord-017527-ylng1us2	376	47	by	by	IN
cord-017527-ylng1us2	376	48	an	an	DT
cord-017527-ylng1us2	376	49	intracellular	intracellular	JJ
cord-017527-ylng1us2	376	50	agent	agent	NN
cord-017527-ylng1us2	376	51	Emergent	Emergent	NNP
cord-017527-ylng1us2	376	52	human	human	JJ
cord-017527-ylng1us2	376	53	pathogen	pathogen	NN
cord-017527-ylng1us2	376	54	simian	simian	JJ
cord-017527-ylng1us2	376	55	virus	virus	NN
cord-017527-ylng1us2	376	56	40	40	CD
cord-017527-ylng1us2	376	57	and	and	CC
cord-017527-ylng1us2	376	58	its	-PRON-	PRP$
cord-017527-ylng1us2	376	59	role	role	NN
cord-017527-ylng1us2	376	60	in	in	IN
cord-017527-ylng1us2	376	61	cancer	cancer	NN
cord-017527-ylng1us2	376	62	Ex	Ex	NNP
cord-017527-ylng1us2	376	63	vivo	vivo	NN
cord-017527-ylng1us2	376	64	propagation	propagation	NN
cord-017527-ylng1us2	376	65	of	of	IN
cord-017527-ylng1us2	376	66	infectious	infectious	JJ
cord-017527-ylng1us2	376	67	sheep	sheep	NN
cord-017527-ylng1us2	376	68	scrapie	scrapie	NN
cord-017527-ylng1us2	376	69	agent	agent	NN
cord-017527-ylng1us2	376	70	in	in	IN
cord-017527-ylng1us2	376	71	heterologous	heterologous	JJ
cord-017527-ylng1us2	376	72	epithelial	epithelial	JJ
cord-017527-ylng1us2	376	73	cells	cell	NNS
cord-017527-ylng1us2	376	74	expressing	express	VBG
cord-017527-ylng1us2	376	75	ovine	ovine	JJ
cord-017527-ylng1us2	376	76	prion	prion	NN
cord-017527-ylng1us2	376	77	protein	protein	NN
cord-017527-ylng1us2	376	78	Cytokine	cytokine	NN
cord-017527-ylng1us2	376	79	-	-	HYPH
cord-017527-ylng1us2	376	80	mediated	mediate	VBN
cord-017527-ylng1us2	376	81	downregulation	downregulation	NN
cord-017527-ylng1us2	376	82	of	of	IN
cord-017527-ylng1us2	376	83	coxsackievirus	coxsackievirus	NNP
cord-017527-ylng1us2	376	84	-	-	HYPH
cord-017527-ylng1us2	376	85	adenovirus	adenovirus	NN
cord-017527-ylng1us2	376	86	receptor	receptor	NN
cord-017527-ylng1us2	376	87	in	in	IN
cord-017527-ylng1us2	376	88	endothelial	endothelial	JJ
cord-017527-ylng1us2	376	89	cells	cell	NNS
cord-017527-ylng1us2	376	90	Susceptibility	susceptibility	NN
cord-017527-ylng1us2	376	91	of	of	IN
cord-017527-ylng1us2	376	92	common	common	JJ
cord-017527-ylng1us2	376	93	fibroblast	fibroblast	NN
cord-017527-ylng1us2	376	94	cell	cell	NN
cord-017527-ylng1us2	376	95	lines	line	NNS
cord-017527-ylng1us2	376	96	to	to	IN
cord-017527-ylng1us2	376	97	transmissible	transmissible	JJ
cord-017527-ylng1us2	376	98	spongiform	spongiform	JJ
cord-017527-ylng1us2	376	99	encephalopathy	encephalopathy	NN
cord-017527-ylng1us2	376	100	agents	agent	NNS
cord-017527-ylng1us2	376	101	Pathogen	Pathogen	NNP
cord-017527-ylng1us2	376	102	survival	survival	NN
cord-017527-ylng1us2	376	103	in	in	IN
cord-017527-ylng1us2	376	104	the	the	DT
cord-017527-ylng1us2	376	105	external	external	JJ
cord-017527-ylng1us2	376	106	environment	environment	NN
cord-017527-ylng1us2	376	107	and	and	CC
cord-017527-ylng1us2	376	108	the	the	DT
cord-017527-ylng1us2	376	109	evolution	evolution	NN
cord-017527-ylng1us2	376	110	of	of	IN
cord-017527-ylng1us2	376	111	virulence	virulence	NN
cord-017527-ylng1us2	376	112	Biology	biology	NN
cord-017527-ylng1us2	376	113	of	of	IN
cord-017527-ylng1us2	376	114	B	B	NNP
cord-017527-ylng1us2	376	115	virus	virus	NN
cord-017527-ylng1us2	376	116	in	in	IN
cord-017527-ylng1us2	376	117	macaque	macaque	NN
cord-017527-ylng1us2	376	118	and	and	CC
cord-017527-ylng1us2	376	119	human	human	JJ
cord-017527-ylng1us2	376	120	hosts	host	NNS
cord-017527-ylng1us2	376	121	,	,	,
cord-017527-ylng1us2	377	1	a	a	DT
cord-017527-ylng1us2	377	2	review	review	NN
cord-017527-ylng1us2	377	3	Herpes	Herpes	NNP
cord-017527-ylng1us2	377	4	simplex	simplex	NN
cord-017527-ylng1us2	377	5	viruses	virus	NNS
cord-017527-ylng1us2	377	6	Laboratory	laboratory	NN
cord-017527-ylng1us2	377	7	-	-	HYPH
cord-017527-ylng1us2	377	8	acquired	acquire	VBN
cord-017527-ylng1us2	377	9	vaccinia	vaccinia	NN
cord-017527-ylng1us2	377	10	infection	infection	NN
cord-017527-ylng1us2	377	11	World	World	NNP
cord-017527-ylng1us2	377	12	Health	Health	NNP
cord-017527-ylng1us2	377	13	Organization	Organization	NNP
cord-017527-ylng1us2	377	14	(	(	-LRB-
cord-017527-ylng1us2	377	15	1998	1998	CD
cord-017527-ylng1us2	377	16	)	)	-RRB-
cord-017527-ylng1us2	378	1	WHO	who	WP
cord-017527-ylng1us2	378	2	requirements	requirement	VBZ
cord-017527-ylng1us2	378	3	for	for	IN
cord-017527-ylng1us2	378	4	the	the	DT
cord-017527-ylng1us2	378	5	use	use	NN
cord-017527-ylng1us2	378	6	of	of	IN
cord-017527-ylng1us2	378	7	animal	animal	NN
cord-017527-ylng1us2	378	8	cells	cell	NNS
cord-017527-ylng1us2	378	9	as	as	IN
cord-017527-ylng1us2	378	10	in	in	IN
cord-017527-ylng1us2	378	11	vitro	vitro	FW
cord-017527-ylng1us2	378	12	substrates	substrate	NNS
cord-017527-ylng1us2	378	13	for	for	IN
cord-017527-ylng1us2	378	14	the	the	DT
cord-017527-ylng1us2	378	15	production	production	NN
cord-017527-ylng1us2	378	16	of	of	IN
cord-017527-ylng1us2	378	17	biologicals	biological	NNS
cord-017527-ylng1us2	378	18	.	.	.
cord-017527-ylng1us2	379	1	WHO	who	WP
cord-017527-ylng1us2	379	2	technical	technical	JJ
cord-017527-ylng1us2	379	3	report	report	NN
cord-017527-ylng1us2	379	4	series	series	NNP
cord-017527-ylng1us2	379	5	Laboratory	Laboratory	NNP
cord-017527-ylng1us2	379	6	biosafety	biosafety	NN
cord-017527-ylng1us2	379	7	manual	manual	NN
cord-017527-ylng1us2	379	8	Manuel	Manuel	NNP
cord-017527-ylng1us2	379	9	of	of	IN
cord-017527-ylng1us2	379	10	diagnostic	diagnostic	JJ
cord-017527-ylng1us2	379	11	tests	test	NNS
cord-017527-ylng1us2	379	12	and	and	CC
cord-017527-ylng1us2	379	13	vaccines	vaccine	NNS
cord-017527-ylng1us2	379	14	for	for	IN
cord-017527-ylng1us2	379	15	terrestrial	terrestrial	JJ
cord-017527-ylng1us2	379	16	animals	animal	NNS
cord-017527-ylng1us2	379	17	.	.	.
cord-017527-ylng1us2	380	1	Chapter	chapter	NN
cord-017527-ylng1us2	380	2	1.1.2	1.1.2	CD
cord-017527-ylng1us2	380	3	biosafety	biosafety	NN
cord-017527-ylng1us2	380	4	and	and	CC
cord-017527-ylng1us2	380	5	biosecurity	biosecurity	NN
cord-017527-ylng1us2	380	6	in	in	IN
cord-017527-ylng1us2	380	7	the	the	DT
cord-017527-ylng1us2	380	8	veterinary	veterinary	JJ
cord-017527-ylng1us2	380	9	microbiology	microbiology	NN
cord-017527-ylng1us2	380	10	laboratory	laboratory	NN
cord-017527-ylng1us2	380	11	and	and	CC
cord-017527-ylng1us2	380	12	animal	animal	NN
cord-017527-ylng1us2	380	13	facilities	facility	NNS
cord-017527-ylng1us2	381	1	Acknowledgments	acknowledgment	NNS
cord-017527-ylng1us2	382	1	The	the	DT
cord-017527-ylng1us2	382	2	authors	author	NNS
cord-017527-ylng1us2	382	3	are	be	VBP
cord-017527-ylng1us2	382	4	grateful	grateful	JJ
cord-017527-ylng1us2	382	5	to	to	IN
cord-017527-ylng1us2	382	6	their	-PRON-	PRP$
cord-017527-ylng1us2	382	7	colleagues	colleague	NNS
cord-017527-ylng1us2	382	8	Dr.	Dr.	NNP
cord-017527-ylng1us2	382	9	Didier	Didier	NNP
cord-017527-ylng1us2	382	10	Breyer	Breyer	NNP
cord-017527-ylng1us2	382	11	and	and	CC
cord-017527-ylng1us2	382	12	Dr.	Dr.	NNP
cord-017527-ylng1us2	382	13	Aline	Aline	NNP
cord-017527-ylng1us2	382	14	Baldo	Baldo	NNP
cord-017527-ylng1us2	382	15	(	(	-LRB-
cord-017527-ylng1us2	382	16	Scientific	Scientific	NNP
cord-017527-ylng1us2	382	17	Institute	Institute	NNP
cord-017527-ylng1us2	382	18	of	of	IN
cord-017527-ylng1us2	382	19	Public	Public	NNP
cord-017527-ylng1us2	382	20	Health	Health	NNP
cord-017527-ylng1us2	382	21	WIV	WIV	NNP
cord-017527-ylng1us2	382	22	-	-	HYPH
cord-017527-ylng1us2	382	23	ISP	ISP	NNP
cord-017527-ylng1us2	382	24	,	,	,
cord-017527-ylng1us2	382	25	Brussels	Brussels	NNP
cord-017527-ylng1us2	382	26	,	,	,
cord-017527-ylng1us2	382	27	Belgium	Belgium	NNP
cord-017527-ylng1us2	382	28	)	)	-RRB-
cord-017527-ylng1us2	382	29	for	for	IN
cord-017527-ylng1us2	382	30	their	-PRON-	PRP$
cord-017527-ylng1us2	382	31	useful	useful	JJ
cord-017527-ylng1us2	382	32	review	review	NN
cord-017527-ylng1us2	382	33	of	of	IN
cord-017527-ylng1us2	382	34	this	this	DT
cord-017527-ylng1us2	382	35	manuscript	manuscript	NN
cord-017527-ylng1us2	382	36	.	.	.